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36 | miRNA-corp.d0 | [
{
"id": "1",
"type": "title",
"text": [
"Identification of blood microRNAs associated to Parkinsońs disease. "
],
"offsets": [
[
0,
70
]
]
},
{
"id": "2",
"type": "abstract",
"text": [
"While miR-1, miR-22* and miR-29 expression levels allowed to distinguish non-treated PD from healthy subjects, miR-16-2*, miR-26a2* and miR30a differentiated treated from untreated patients. "
],
"offsets": [
[
71,
262
]
]
},
{
"id": "3",
"type": "abstract",
"text": [
"They form two groups according to their expression profile in control, non-treated, early-onset and treated Parkinson's disease subjects. "
],
"offsets": [
[
263,
401
]
]
},
{
"id": "4",
"type": "abstract",
"text": [
"A set of six differentially expressed microRNAs were identified. "
],
"offsets": [
[
402,
467
]
]
},
{
"id": "5",
"type": "abstract",
"text": [
"The present study demonstrates that blood samples can be used as a source of miRNA identification associated to Parkinson's disease (PD). "
],
"offsets": [
[
468,
606
]
]
},
{
"id": "6",
"type": "abstract",
"text": [
"This study is innovative in contributing to the development of effective PD biomarkers. "
],
"offsets": [
[
607,
697
]
]
}
] | [
{
"id": "7",
"type": "Non-Specific_miRNAs",
"text": [
"microRNAs"
],
"offsets": [
[
24,
33
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d0.s0.e0"
}
]
},
{
"id": "8",
"type": "Diseases",
"text": [
"Parkinsońs disease"
],
"offsets": [
[
48,
67
]
],
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{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d0.s0.e1"
}
]
},
{
"id": "9",
"type": "Relation_Trigger",
"text": [
"associated"
],
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[
34,
44
]
],
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{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d0.s0.e2"
}
]
},
{
"id": "10",
"type": "Diseases",
"text": [
"PD"
],
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[
156,
158
]
],
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{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d0.s1.e0"
}
]
},
{
"id": "11",
"type": "Specific_miRNAs",
"text": [
"miR-1"
],
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[
77,
82
]
],
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{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d0.s1.e1"
}
]
},
{
"id": "12",
"type": "Specific_miRNAs",
"text": [
"miR-22"
],
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[
84,
90
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],
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{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d0.s1.e2"
}
]
},
{
"id": "13",
"type": "Specific_miRNAs",
"text": [
"miR-29"
],
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[
96,
102
]
],
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{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d0.s1.e3"
}
]
},
{
"id": "14",
"type": "Specific_miRNAs",
"text": [
"miR-16-2"
],
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[
182,
190
]
],
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{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d0.s1.e4"
}
]
},
{
"id": "15",
"type": "Specific_miRNAs",
"text": [
"miR-26a2"
],
"offsets": [
[
193,
201
]
],
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{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d0.s1.e5"
}
]
},
{
"id": "16",
"type": "Specific_miRNAs",
"text": [
"miR30a"
],
"offsets": [
[
207,
213
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d0.s1.e6"
}
]
},
{
"id": "17",
"type": "Relation_Trigger",
"text": [
"expression levels allowed to distinguish"
],
"offsets": [
[
103,
143
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d0.s1.e7"
}
]
},
{
"id": "18",
"type": "Species",
"text": [
"patients"
],
"offsets": [
[
252,
260
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d0.s1.e8"
}
]
},
{
"id": "19",
"type": "Diseases",
"text": [
"Parkinson's disease"
],
"offsets": [
[
371,
390
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d0.s2.e0"
}
]
},
{
"id": "20",
"type": "Non-Specific_miRNAs",
"text": [
"microRNAs"
],
"offsets": [
[
440,
449
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d0.s3.e0"
}
]
},
{
"id": "21",
"type": "Relation_Trigger",
"text": [
"differentially expressed"
],
"offsets": [
[
415,
439
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d0.s3.e1"
}
]
},
{
"id": "22",
"type": "Non-Specific_miRNAs",
"text": [
"miRNA"
],
"offsets": [
[
545,
550
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d0.s4.e0"
}
]
},
{
"id": "23",
"type": "Diseases",
"text": [
"Parkinson's disease"
],
"offsets": [
[
580,
599
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d0.s4.e1"
}
]
},
{
"id": "24",
"type": "Diseases",
"text": [
"PD"
],
"offsets": [
[
601,
603
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d0.s4.e2"
}
]
},
{
"id": "25",
"type": "Relation_Trigger",
"text": [
"associated"
],
"offsets": [
[
566,
576
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d0.s4.e3"
}
]
},
{
"id": "26",
"type": "Diseases",
"text": [
"PD"
],
"offsets": [
[
680,
682
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d0.s5.e0"
}
]
}
] | [] | [] | [
{
"id": "27",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d0.s0.e0",
"arg2_id": "miRNA-corp.d0.s0.e1",
"normalized": []
},
{
"id": "28",
"type": "Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d0.s1.e1",
"arg2_id": "miRNA-corp.d0.s1.e0",
"normalized": []
},
{
"id": "29",
"type": "Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d0.s1.e2",
"arg2_id": "miRNA-corp.d0.s1.e0",
"normalized": []
},
{
"id": "30",
"type": "Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d0.s1.e3",
"arg2_id": "miRNA-corp.d0.s1.e0",
"normalized": []
},
{
"id": "31",
"type": "Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d0.s1.e4",
"arg2_id": "miRNA-corp.d0.s1.e0",
"normalized": []
},
{
"id": "32",
"type": "Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d0.s1.e5",
"arg2_id": "miRNA-corp.d0.s1.e0",
"normalized": []
},
{
"id": "33",
"type": "Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d0.s1.e6",
"arg2_id": "miRNA-corp.d0.s1.e0",
"normalized": []
},
{
"id": "34",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d0.s4.e0",
"arg2_id": "miRNA-corp.d0.s4.e1",
"normalized": []
},
{
"id": "35",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d0.s4.e0",
"arg2_id": "miRNA-corp.d0.s4.e2",
"normalized": []
}
] |
153 | miRNA-corp.d1 | [
{
"id": "37",
"type": "title",
"text": [
"This reveals a previously unrecognized signaling cascade involved in meningioma tumor development and highlights a novel molecular interaction between miR-200a and Wnt signaling, thereby providing insights into novel therapies for meningiomas. "
],
"offsets": [
[
0,
246
]
]
},
{
"id": "38",
"type": "abstract",
"text": [
"A direct correlation was found between the downregulation of miR-200a and the upregulation of beta-catenin in human meningioma samples. "
],
"offsets": [
[
247,
383
]
]
},
{
"id": "39",
"type": "abstract",
"text": [
"Thus, miR-200a appears to act as a multifunctional tumor suppressor miRNA in meningiomas through effects on the E-cadherin and Wnt/beta-catenin signaling pathways. "
],
"offsets": [
[
384,
548
]
]
},
{
"id": "40",
"type": "abstract",
"text": [
"miR-200a was found to directly target beta-catenin mRNA, thereby inhibiting its translation and blocking Wnt/beta-catenin signaling, which is frequently involved in cancer. "
],
"offsets": [
[
549,
722
]
]
},
{
"id": "41",
"type": "abstract",
"text": [
"Downregulation of miR-200a in meningiomas and arachnoidal cells resulted in increased expression of beta-catenin and cyclin D1 involved in cell proliferation. "
],
"offsets": [
[
723,
882
]
]
},
{
"id": "42",
"type": "abstract",
"text": [
"Upregulation of miR-200a decreased the expression of transcription factors ZEB1 and SIP1, with consequent increased expression of E-cadherin, an adhesion protein associated with cell differentiation. "
],
"offsets": [
[
883,
1083
]
]
},
{
"id": "43",
"type": "abstract",
"text": [
"Elevated levels of miR-200a inhibited meningioma cell growth in culture and in a tumor model in vivo. "
],
"offsets": [
[
1084,
1186
]
]
},
{
"id": "44",
"type": "abstract",
"text": [
"Meningiomas, one of the most common human brain tumors, are derived from arachnoidal cells associated with brain meninges, are usually benign, and are frequently associated with neurofibromatosis type 2. Here, we define a typical human meningioma microRNA (miRNA) profile and characterize the effects of one downregulated miRNA, miR-200a, on tumor growth. "
],
"offsets": [
[
1187,
1543
]
]
},
{
"id": "45",
"type": "abstract",
"text": [
"Downregulated microRNA-200a in meningiomas promotes tumor growth by reducing E-cadherin and activating the Wnt/beta-catenin signaling pathway. "
],
"offsets": [
[
1544,
1688
]
]
}
] | [
{
"id": "46",
"type": "Specific_miRNAs",
"text": [
"miR-200a"
],
"offsets": [
[
151,
159
]
],
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{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d1.s0.e0"
}
]
},
{
"id": "47",
"type": "Diseases",
"text": [
"meningioma tumor"
],
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[
69,
85
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],
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"db_name": "miRNA-corpus",
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]
},
{
"id": "48",
"type": "Diseases",
"text": [
"meningiomas"
],
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[
231,
242
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],
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]
},
{
"id": "49",
"type": "Specific_miRNAs",
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"miR-200a"
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308,
316
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},
{
"id": "50",
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"meningioma"
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363,
373
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],
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{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d1.s1.e1"
}
]
},
{
"id": "51",
"type": "Genes/Proteins",
"text": [
"beta-catenin"
],
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341,
353
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],
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{
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]
},
{
"id": "52",
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"downregulation"
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290,
304
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},
{
"id": "53",
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"upregulation"
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},
{
"id": "54",
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267
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},
{
"id": "55",
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"human"
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357,
362
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},
{
"id": "56",
"type": "Specific_miRNAs",
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"miR-200a"
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390,
398
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]
},
{
"id": "57",
"type": "Genes/Proteins",
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"E-cadherin"
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[
496,
506
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],
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]
},
{
"id": "58",
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"miRNA"
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452,
457
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]
},
{
"id": "59",
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"meningiomas"
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461,
472
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}
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},
{
"id": "60",
"type": "Relation_Trigger",
"text": [
"tumor suppressor"
],
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[
435,
451
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{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d1.s2.e4"
}
]
},
{
"id": "61",
"type": "Genes/Proteins",
"text": [
"beta-catenin"
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[
515,
527
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],
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{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d1.s2.e5"
}
]
},
{
"id": "62",
"type": "Specific_miRNAs",
"text": [
"miR-200a"
],
"offsets": [
[
549,
557
]
],
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{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d1.s3.e0"
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]
},
{
"id": "63",
"type": "Genes/Proteins",
"text": [
"beta-catenin"
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[
587,
599
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],
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{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d1.s3.e1"
}
]
},
{
"id": "64",
"type": "Relation_Trigger",
"text": [
"inhibiting its translation"
],
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[
614,
640
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d1.s3.e2"
}
]
},
{
"id": "65",
"type": "Relation_Trigger",
"text": [
"blocking"
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[
645,
653
]
],
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{
"db_name": "miRNA-corpus",
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}
]
},
{
"id": "66",
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"text": [
"directly target"
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[
571,
586
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],
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{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d1.s3.e4"
}
]
},
{
"id": "67",
"type": "Genes/Proteins",
"text": [
"beta-catenin"
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[
658,
670
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{
"db_name": "miRNA-corpus",
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]
},
{
"id": "68",
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"text": [
"cancer"
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714,
720
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{
"db_name": "miRNA-corpus",
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}
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},
{
"id": "69",
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"miR-200a"
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[
741,
749
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],
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{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d1.s4.e0"
}
]
},
{
"id": "70",
"type": "Genes/Proteins",
"text": [
"cyclin D1"
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[
840,
849
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],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d1.s4.e1"
}
]
},
{
"id": "71",
"type": "Genes/Proteins",
"text": [
"beta-catenin"
],
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[
823,
835
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d1.s4.e2"
}
]
},
{
"id": "72",
"type": "Diseases",
"text": [
"meningiomas"
],
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[
753,
764
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],
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{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d1.s4.e3"
}
]
},
{
"id": "73",
"type": "Relation_Trigger",
"text": [
"Downregulation"
],
"offsets": [
[
723,
737
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d1.s4.e4"
}
]
},
{
"id": "74",
"type": "Relation_Trigger",
"text": [
"increased expression"
],
"offsets": [
[
799,
819
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d1.s4.e5"
}
]
},
{
"id": "75",
"type": "Specific_miRNAs",
"text": [
"miR-200a"
],
"offsets": [
[
899,
907
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d1.s5.e0"
}
]
},
{
"id": "76",
"type": "Genes/Proteins",
"text": [
"ZEB1"
],
"offsets": [
[
958,
962
]
],
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{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d1.s5.e1"
}
]
},
{
"id": "77",
"type": "Genes/Proteins",
"text": [
"E-cadherin"
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225 | miRNA-corp.d2 | [
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265 | miRNA-corp.d3 | [
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"db_id": "miRNA-corp.d3.s3.e4"
}
]
},
{
"id": "242",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
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333,
339
]
],
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{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d3.s4.e0"
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]
},
{
"id": "243",
"type": "Non-Specific_miRNAs",
"text": [
"miRNA"
],
"offsets": [
[
377,
382
]
],
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{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d3.s4.e1"
}
]
},
{
"id": "244",
"type": "Species",
"text": [
"humans"
],
"offsets": [
[
590,
596
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d3.s4.e2"
}
]
},
{
"id": "245",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
[
628,
634
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d3.s5.e0"
}
]
},
{
"id": "246",
"type": "Relation_Trigger",
"text": [
"regulators"
],
"offsets": [
[
648,
658
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d3.s5.e1"
}
]
},
{
"id": "247",
"type": "Non-Specific_miRNAs",
"text": [
"microRNAs"
],
"offsets": [
[
756,
765
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d3.s7.e0"
}
]
},
{
"id": "248",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
[
767,
773
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d3.s7.e1"
}
]
},
{
"id": "249",
"type": "Non-Specific_miRNAs",
"text": [
"MicroRNA"
],
"offsets": [
[
854,
862
]
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"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d3.s8.e0"
}
]
},
{
"id": "250",
"type": "Diseases",
"text": [
"Alzheimer's disease"
],
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[
1088,
1107
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"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d3.s9.e0"
}
]
},
{
"id": "251",
"type": "Diseases",
"text": [
"hypertensive"
],
"offsets": [
[
1066,
1078
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"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d3.s9.e1"
}
]
},
{
"id": "252",
"type": "Diseases",
"text": [
"heart disease"
],
"offsets": [
[
1022,
1035
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"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d3.s9.e2"
}
]
},
{
"id": "253",
"type": "Diseases",
"text": [
"neurodegenerative disorders"
],
"offsets": [
[
1118,
1145
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d3.s9.e3"
}
]
},
{
"id": "254",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
[
1305,
1311
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d3.s10.e0"
}
]
},
{
"id": "255",
"type": "Relation_Trigger",
"text": [
"regulation"
],
"offsets": [
[
1278,
1288
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d3.s10.e1"
}
]
},
{
"id": "256",
"type": "Relation_Trigger",
"text": [
"regulatory"
],
"offsets": [
[
1378,
1388
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d3.s10.e2"
}
]
},
{
"id": "257",
"type": "Non-Specific_miRNAs",
"text": [
"miRNA"
],
"offsets": [
[
1574,
1579
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d3.s11.e0"
}
]
},
{
"id": "258",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
[
1619,
1625
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d3.s11.e1"
}
]
},
{
"id": "259",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
[
1508,
1514
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d3.s11.e2"
}
]
},
{
"id": "260",
"type": "Relation_Trigger",
"text": [
"regulating"
],
"offsets": [
[
1629,
1639
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d3.s11.e3"
}
]
},
{
"id": "261",
"type": "Diseases",
"text": [
"cancer"
],
"offsets": [
[
1653,
1659
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d3.s11.e4"
}
]
}
] | [] | [] | [
{
"id": "262",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d3.s11.e2",
"arg2_id": "miRNA-corp.d3.s11.e4",
"normalized": []
},
{
"id": "263",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d3.s11.e0",
"arg2_id": "miRNA-corp.d3.s11.e4",
"normalized": []
},
{
"id": "264",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d3.s11.e1",
"arg2_id": "miRNA-corp.d3.s11.e4",
"normalized": []
}
] |
294 | miRNA-corp.d4 | [
{
"id": "266",
"type": "title",
"text": [
"METHODS: We prospectively collected surgical outcome data for 2 to 11 years for 134 consecutive patients who specifically had MTLE and unilateral HS, according to magnetic resonance imaging (MRI) and confirmed by histopathology. "
],
"offsets": [
[
0,
229
]
]
},
{
"id": "267",
"type": "abstract",
"text": [
"PURPOSE: Surgical results in patients with mesial temporal lobe epilepsy due to hippocampal sclerosis (MTLE/HS) are often reported in conjunction with other etiologies of TLE. "
],
"offsets": [
[
230,
406
]
]
},
{
"id": "268",
"type": "abstract",
"text": [
"Survival analysis of the surgical outcome of temporal lobe epilepsy due to hippocampal sclerosis. "
],
"offsets": [
[
407,
506
]
]
},
{
"id": "269",
"type": "abstract",
"text": [
"Of the patients tested, 26% of those operated on the left side and 22% of those operated on the right had postoperative decline of >1 SD in verbal or visual memory, respectively. "
],
"offsets": [
[
507,
686
]
]
},
{
"id": "270",
"type": "abstract",
"text": [
"CONCLUSIONS: High rates of seizure freedom can be obtained and remain stable over the years in patients operated on for unilateral MTLE/HS, even in countries with limited resources. "
],
"offsets": [
[
687,
871
]
]
},
{
"id": "271",
"type": "abstract",
"text": [
"RESULTS: Kaplan-Meier estimates of complete seizure freedom (Engel's class IA) for years 1, 2, 5, and 10 were 85%, 77%, 74%, and 66%, and of Engel's class I were 89%, 86%, 83%, and 81%. "
],
"offsets": [
[
872,
1058
]
]
},
{
"id": "272",
"type": "abstract",
"text": [
"Only nine (6.7%) patients had outcome classes III or IV at any point during follow-up. "
],
"offsets": [
[
1059,
1146
]
]
},
{
"id": "273",
"type": "abstract",
"text": [
"Outcome was analyzed by using Engel's classification (a) through Kaplan-Meier estimated survival curves (as a function of the time to seizure recurrence), (b) as percentage of patients in each outcome class on a yearly basis, and (c) at the last updated follow-up. "
],
"offsets": [
[
1147,
1412
]
]
}
] | [
{
"id": "274",
"type": "Diseases",
"text": [
"MTLE"
],
"offsets": [
[
126,
130
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d4.s0.e0"
}
]
},
{
"id": "275",
"type": "Diseases",
"text": [
"HS"
],
"offsets": [
[
146,
148
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d4.s0.e1"
}
]
},
{
"id": "276",
"type": "Species",
"text": [
"patients"
],
"offsets": [
[
96,
104
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d4.s0.e2"
}
]
},
{
"id": "277",
"type": "Diseases",
"text": [
"mesial temporal lobe epilepsy"
],
"offsets": [
[
273,
302
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d4.s1.e0"
}
]
},
{
"id": "278",
"type": "Diseases",
"text": [
"MTLE"
],
"offsets": [
[
333,
337
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d4.s1.e1"
}
]
},
{
"id": "279",
"type": "Diseases",
"text": [
"hippocampal sclerosis"
],
"offsets": [
[
310,
331
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d4.s1.e2"
}
]
},
{
"id": "280",
"type": "Diseases",
"text": [
"HS"
],
"offsets": [
[
338,
340
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d4.s1.e3"
}
]
},
{
"id": "281",
"type": "Diseases",
"text": [
"TLE"
],
"offsets": [
[
401,
404
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d4.s1.e4"
}
]
},
{
"id": "282",
"type": "Species",
"text": [
"patients"
],
"offsets": [
[
259,
267
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d4.s1.e5"
}
]
},
{
"id": "283",
"type": "Diseases",
"text": [
"temporal lobe epilepsy"
],
"offsets": [
[
452,
474
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d4.s2.e0"
}
]
},
{
"id": "284",
"type": "Diseases",
"text": [
"hippocampal sclerosis"
],
"offsets": [
[
482,
503
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d4.s2.e1"
}
]
},
{
"id": "285",
"type": "Species",
"text": [
"patients"
],
"offsets": [
[
514,
522
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d4.s3.e0"
}
]
},
{
"id": "286",
"type": "Species",
"text": [
"patients"
],
"offsets": [
[
782,
790
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d4.s4.e0"
}
]
},
{
"id": "287",
"type": "Diseases",
"text": [
"MTLE"
],
"offsets": [
[
818,
822
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d4.s4.e1"
}
]
},
{
"id": "288",
"type": "Diseases",
"text": [
"HS"
],
"offsets": [
[
823,
825
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d4.s4.e2"
}
]
},
{
"id": "289",
"type": "Diseases",
"text": [
"seizure"
],
"offsets": [
[
714,
721
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d4.s4.e3"
}
]
},
{
"id": "290",
"type": "Diseases",
"text": [
"seizure"
],
"offsets": [
[
916,
923
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d4.s5.e0"
}
]
},
{
"id": "291",
"type": "Species",
"text": [
"patients"
],
"offsets": [
[
1076,
1084
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d4.s6.e0"
}
]
},
{
"id": "292",
"type": "Diseases",
"text": [
"seizure"
],
"offsets": [
[
1281,
1288
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d4.s8.e0"
}
]
},
{
"id": "293",
"type": "Species",
"text": [
"patients"
],
"offsets": [
[
1323,
1331
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d4.s8.e1"
}
]
}
] | [] | [] | [] |
378 | miRNA-corp.d5 | [
{
"id": "295",
"type": "title",
"text": [
"Western blot analysis of human glioblastoma specimens showed high levels of PKM2 protein, but none was observed in normal brain samples. "
],
"offsets": [
[
0,
137
]
]
},
{
"id": "296",
"type": "abstract",
"text": [
"Our data suggest PKM2 inhibition as a therapy for glioblastoma, with the potential for minimal toxicity to the brain. "
],
"offsets": [
[
138,
258
]
]
},
{
"id": "297",
"type": "abstract",
"text": [
"Strikingly, cells with high levels of PKM2 expressed lower levels of miR-326, suggestive of endogenous regulation of PKM2 by miR-326. "
],
"offsets": [
[
259,
393
]
]
},
{
"id": "298",
"type": "abstract",
"text": [
"Emerging studies have identified microRNAs (miRNAs) as possible therapeutic tools for the treatment of glioma, the most aggressive brain tumor. "
],
"offsets": [
[
394,
538
]
]
},
{
"id": "299",
"type": "abstract",
"text": [
"Pyruvate kinase M2 is a target of the tumor-suppressive microRNA-326 and regulates the survival of glioma cells. "
],
"offsets": [
[
539,
653
]
]
},
{
"id": "300",
"type": "abstract",
"text": [
"Their important targets in this tumor are not well understood. "
],
"offsets": [
[
654,
717
]
]
},
{
"id": "301",
"type": "abstract",
"text": [
"We recently found that the Notch pathway is a target of miRNA-326. "
],
"offsets": [
[
718,
785
]
]
},
{
"id": "302",
"type": "abstract",
"text": [
"Ectopic expression of miRNA-326 in glioma and glioma stem cells induced their apoptosis and reduced their metabolic activity. "
],
"offsets": [
[
786,
912
]
]
},
{
"id": "303",
"type": "abstract",
"text": [
"Computational target gene prediction revealed pyruvate kinase type M2 (PKM2) as another target of miRNA-326. "
],
"offsets": [
[
913,
1022
]
]
},
{
"id": "304",
"type": "abstract",
"text": [
"PKM2 has recently been shown to play a key role in cancer cell metabolism. "
],
"offsets": [
[
1023,
1098
]
]
},
{
"id": "305",
"type": "abstract",
"text": [
"To investigate whether it might be a functionally important target of miR-326, we used RNA interference to knockdown PKM2 expression in glioma cells. "
],
"offsets": [
[
1099,
1249
]
]
},
{
"id": "306",
"type": "abstract",
"text": [
"Transfection of the established glioma and glioma stem cells with PKM2 siRNA reduced their growth, cellular invasion, metabolic activity, ATP and glutathione levels, and activated AMP-activated protein kinase. "
],
"offsets": [
[
1250,
1460
]
]
},
{
"id": "307",
"type": "abstract",
"text": [
"The cytotoxic effects exhibited by PKM2 knockdown in glioma and glioma stem cells were not observed in transformed human astrocytes. "
],
"offsets": [
[
1461,
1594
]
]
}
] | [
{
"id": "308",
"type": "Genes/Proteins",
"text": [
"PKM2"
],
"offsets": [
[
76,
80
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d5.s0.e0"
}
]
},
{
"id": "309",
"type": "Diseases",
"text": [
"glioblastoma"
],
"offsets": [
[
31,
43
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d5.s0.e1"
}
]
},
{
"id": "310",
"type": "Relation_Trigger",
"text": [
"high levels of PKM2 protein"
],
"offsets": [
[
61,
88
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d5.s0.e2"
}
]
},
{
"id": "311",
"type": "Species",
"text": [
"human"
],
"offsets": [
[
25,
30
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d5.s0.e3"
}
]
},
{
"id": "312",
"type": "Genes/Proteins",
"text": [
"PKM2"
],
"offsets": [
[
155,
159
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d5.s1.e0"
}
]
},
{
"id": "313",
"type": "Diseases",
"text": [
"glioblastoma"
],
"offsets": [
[
188,
200
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d5.s1.e1"
}
]
},
{
"id": "314",
"type": "Relation_Trigger",
"text": [
"inhibition"
],
"offsets": [
[
160,
170
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d5.s1.e2"
}
]
},
{
"id": "315",
"type": "Specific_miRNAs",
"text": [
"miR-326"
],
"offsets": [
[
384,
391
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d5.s2.e0"
}
]
},
{
"id": "316",
"type": "Specific_miRNAs",
"text": [
"miR-326"
],
"offsets": [
[
328,
335
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d5.s2.e1"
}
]
},
{
"id": "317",
"type": "Genes/Proteins",
"text": [
"PKM2"
],
"offsets": [
[
297,
301
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d5.s2.e2"
}
]
},
{
"id": "318",
"type": "Genes/Proteins",
"text": [
"PKM2"
],
"offsets": [
[
376,
380
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d5.s2.e3"
}
]
},
{
"id": "319",
"type": "Relation_Trigger",
"text": [
"high levels"
],
"offsets": [
[
282,
293
]
],
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] | [] | [] | [
{
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{
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{
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{
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] |
452 | miRNA-corp.d6 | [
{
"id": "379",
"type": "title",
"text": [
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],
"offsets": [
[
0,
130
]
]
},
{
"id": "380",
"type": "abstract",
"text": [
"Here we provide an overview of the following: (1) the evolution of miR-15/107 group member genes; (2) the expression levels of miRNAs in mammalian tissues; (3) evidence for overlapping gene-regulatory functions by different miRNAs; (4) the normal biochemical pathways regulated by miR-15/107 group miRNAs; and (5) the roles played by these miRNAs in human diseases. "
],
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131,
497
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{
"id": "381",
"type": "abstract",
"text": [
"While all vertebrates studied to date express miR-15a, miR-15b, miR-16, miR-103, and miR-107, mammals alone are known to express miR-195, miR-424, miR-497, miR-503, and miR-646. "
],
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498,
676
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]
},
{
"id": "382",
"type": "abstract",
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],
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[
677,
836
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]
},
{
"id": "383",
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],
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837,
1004
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]
},
{
"id": "384",
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],
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1005,
1114
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]
},
{
"id": "385",
"type": "abstract",
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[
1115,
1227
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{
"id": "386",
"type": "abstract",
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],
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1228,
1336
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},
{
"id": "387",
"type": "abstract",
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1337,
1471
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},
{
"id": "388",
"type": "abstract",
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],
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1472,
1621
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},
{
"id": "389",
"type": "abstract",
"text": [
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],
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1622,
1812
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{
"id": "390",
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],
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1813,
2027
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{
"id": "391",
"type": "abstract",
"text": [
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],
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2028,
2106
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81,
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198,
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412,
422
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258,
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] | [] | [] | [
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] |
487 | miRNA-corp.d7 | [
{
"id": "453",
"type": "title",
"text": [
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],
"offsets": [
[
0,
103
]
]
},
{
"id": "454",
"type": "abstract",
"text": [
"METHODS: To normalize the GAD67 expression in the striatum after dopamine depletion, we developed several lentiviral vectors that express RNA interference (RNAi) directed against GAD67 mitochondrial RNA. "
],
"offsets": [
[
104,
308
]
]
},
{
"id": "455",
"type": "abstract",
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"The vectors were injected into the striatum of hemiparkinsonian rats and the level of GAD67 protein as well as a marker of neuronal activity, mtCO1, was analyzed using western blots. "
],
"offsets": [
[
309,
492
]
]
},
{
"id": "456",
"type": "abstract",
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],
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493,
588
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]
},
{
"id": "457",
"type": "abstract",
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],
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[
589,
745
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]
},
{
"id": "458",
"type": "abstract",
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],
"offsets": [
[
746,
907
]
]
},
{
"id": "459",
"type": "abstract",
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],
"offsets": [
[
908,
1052
]
]
},
{
"id": "460",
"type": "abstract",
"text": [
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],
"offsets": [
[
1053,
1202
]
]
},
{
"id": "461",
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],
"offsets": [
[
1203,
1308
]
]
},
{
"id": "462",
"type": "abstract",
"text": [
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],
"offsets": [
[
1309,
1488
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]
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"id": "473",
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},
{
"id": "550",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d9.s4.e1",
"arg2_id": "miRNA-corp.d9.s4.e0",
"normalized": []
}
] |
614 | miRNA-corp.d10 | [
{
"id": "552",
"type": "title",
"text": [
"While confirmation is required, this study suggests that microRNA mutations can contribute to schizophrenia. "
],
"offsets": [
[
0,
111
]
]
},
{
"id": "553",
"type": "abstract",
"text": [
"One ultra-rare variant was identified in a control sample (with a history of depression) (8/193 versus 1/191, p = 0.02 by one-sided Fisher's exact test, odds ratio = 8.2). "
],
"offsets": [
[
112,
284
]
]
},
{
"id": "554",
"type": "abstract",
"text": [
"CONCLUSIONS: Functional analyses of ectopically expressed copies of the variant miRNA precursors demonstrate loss of function, gain of function or altered expression levels. "
],
"offsets": [
[
285,
459
]
]
},
{
"id": "555",
"type": "abstract",
"text": [
"In addition, components required for miRNA processing and/or function have also been implicated in X-linked mental retardation, neurological and neoplastic diseases, pointing to the wide ranging involvement of miRNAs in disease. "
],
"offsets": [
[
460,
689
]
]
},
{
"id": "556",
"type": "abstract",
"text": [
"METHODS AND FINDINGS: To explore the role of miRNAs in schizophrenia, 59 microRNA genes on the X-chromosome were amplified and sequenced in males with (193) and without (191) schizophrenia spectrum disorders to test the hypothesis that ultra-rare mutations in microRNA collectively contribute to the risk of schizophrenia. "
],
"offsets": [
[
690,
1013
]
]
},
{
"id": "557",
"type": "abstract",
"text": [
"Here we provide the first association of microRNA gene dysfunction with schizophrenia. "
],
"offsets": [
[
1014,
1101
]
]
},
{
"id": "558",
"type": "abstract",
"text": [
"Eight ultra-rare variants in the precursor or mature miRNA were identified in eight distinct miRNA genes in 4% of analyzed males with schizophrenia. "
],
"offsets": [
[
1102,
1251
]
]
},
{
"id": "559",
"type": "abstract",
"text": [
"Evidence for X-chromosomal schizophrenia associated with microRNA alterations. "
],
"offsets": [
[
1252,
1332
]
]
},
{
"id": "560",
"type": "abstract",
"text": [
"BACKGROUND: Schizophrenia is a severe disabling brain disease affecting about 1% of the population. "
],
"offsets": [
[
1333,
1433
]
]
},
{
"id": "561",
"type": "abstract",
"text": [
"Individual microRNAs (miRNAs) affect moderate downregulation of gene expression. "
],
"offsets": [
[
1434,
1515
]
]
}
] | [
{
"id": "562",
"type": "Non-Specific_miRNAs",
"text": [
"microRNA"
],
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[
57,
65
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d10.s0.e0"
}
]
},
{
"id": "563",
"type": "Diseases",
"text": [
"schizophrenia"
],
"offsets": [
[
94,
107
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d10.s0.e1"
}
]
},
{
"id": "564",
"type": "Diseases",
"text": [
"depression"
],
"offsets": [
[
189,
199
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d10.s1.e0"
}
]
},
{
"id": "565",
"type": "Non-Specific_miRNAs",
"text": [
"miRNA"
],
"offsets": [
[
365,
370
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d10.s3.e0"
}
]
},
{
"id": "566",
"type": "Relation_Trigger",
"text": [
"miRNA precursors demonstrate loss"
],
"offsets": [
[
365,
398
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d10.s3.e1"
}
]
},
{
"id": "567",
"type": "Relation_Trigger",
"text": [
"ectopically expressed"
],
"offsets": [
[
321,
342
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d10.s3.e2"
}
]
},
{
"id": "568",
"type": "Relation_Trigger",
"text": [
"altered expression levels"
],
"offsets": [
[
432,
457
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d10.s3.e3"
}
]
},
{
"id": "569",
"type": "Non-Specific_miRNAs",
"text": [
"miRNA"
],
"offsets": [
[
497,
502
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d10.s4.e0"
}
]
},
{
"id": "570",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
[
670,
676
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d10.s4.e1"
}
]
},
{
"id": "571",
"type": "Diseases",
"text": [
"X-linked mental retardation"
],
"offsets": [
[
559,
586
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d10.s4.e2"
}
]
},
{
"id": "572",
"type": "Diseases",
"text": [
"neoplastic diseases"
],
"offsets": [
[
605,
624
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d10.s4.e3"
}
]
},
{
"id": "573",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
[
735,
741
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d10.s5.e0"
}
]
},
{
"id": "574",
"type": "Non-Specific_miRNAs",
"text": [
"microRNA"
],
"offsets": [
[
763,
771
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d10.s5.e1"
}
]
},
{
"id": "575",
"type": "Non-Specific_miRNAs",
"text": [
"microRNA"
],
"offsets": [
[
950,
958
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d10.s5.e2"
}
]
},
{
"id": "576",
"type": "Diseases",
"text": [
"schizophrenia"
],
"offsets": [
[
865,
878
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d10.s5.e3"
}
]
},
{
"id": "577",
"type": "Diseases",
"text": [
"schizophrenia"
],
"offsets": [
[
998,
1011
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d10.s5.e4"
}
]
},
{
"id": "578",
"type": "Diseases",
"text": [
"schizophrenia"
],
"offsets": [
[
745,
758
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d10.s5.e5"
}
]
},
{
"id": "579",
"type": "Relation_Trigger",
"text": [
"amplified"
],
"offsets": [
[
803,
812
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d10.s5.e6"
}
]
},
{
"id": "580",
"type": "Non-Specific_miRNAs",
"text": [
"microRNA"
],
"offsets": [
[
1055,
1063
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d10.s6.e0"
}
]
},
{
"id": "581",
"type": "Diseases",
"text": [
"schizophrenia"
],
"offsets": [
[
1086,
1099
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d10.s6.e1"
}
]
},
{
"id": "582",
"type": "Relation_Trigger",
"text": [
"association"
],
"offsets": [
[
1040,
1051
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d10.s6.e2"
}
]
},
{
"id": "583",
"type": "Relation_Trigger",
"text": [
"dysfunction"
],
"offsets": [
[
1069,
1080
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d10.s6.e3"
}
]
},
{
"id": "584",
"type": "Non-Specific_miRNAs",
"text": [
"miRNA"
],
"offsets": [
[
1155,
1160
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d10.s7.e0"
}
]
},
{
"id": "585",
"type": "Non-Specific_miRNAs",
"text": [
"miRNA"
],
"offsets": [
[
1195,
1200
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d10.s7.e1"
}
]
},
{
"id": "586",
"type": "Diseases",
"text": [
"schizophrenia"
],
"offsets": [
[
1236,
1249
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d10.s7.e2"
}
]
},
{
"id": "587",
"type": "Non-Specific_miRNAs",
"text": [
"microRNA"
],
"offsets": [
[
1309,
1317
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d10.s8.e0"
}
]
},
{
"id": "588",
"type": "Relation_Trigger",
"text": [
"associated"
],
"offsets": [
[
1293,
1303
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d10.s8.e1"
}
]
},
{
"id": "589",
"type": "Diseases",
"text": [
"X-chromosomal schizophrenia"
],
"offsets": [
[
1265,
1292
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d10.s8.e2"
}
]
},
{
"id": "590",
"type": "Diseases",
"text": [
"Schizophrenia"
],
"offsets": [
[
1345,
1358
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d10.s9.e0"
}
]
},
{
"id": "591",
"type": "Diseases",
"text": [
"brain disease"
],
"offsets": [
[
1381,
1394
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d10.s9.e1"
}
]
},
{
"id": "592",
"type": "Diseases",
"text": [
"Schizophrenia"
],
"offsets": [
[
1345,
1358
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d10.s9.e2"
}
]
},
{
"id": "593",
"type": "Non-Specific_miRNAs",
"text": [
"microRNAs"
],
"offsets": [
[
1445,
1454
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d10.s10.e0"
}
]
},
{
"id": "594",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
[
1456,
1462
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d10.s10.e1"
}
]
},
{
"id": "595",
"type": "Relation_Trigger",
"text": [
"downregulation of gene expression"
],
"offsets": [
[
1480,
1513
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d10.s10.e2"
}
]
}
] | [] | [] | [
{
"id": "596",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d10.s0.e0",
"arg2_id": "miRNA-corp.d10.s0.e1",
"normalized": []
},
{
"id": "597",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d10.s4.e0",
"arg2_id": "miRNA-corp.d10.s4.e2",
"normalized": []
},
{
"id": "598",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d10.s4.e0",
"arg2_id": "miRNA-corp.d10.s4.e3",
"normalized": []
},
{
"id": "599",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d10.s4.e1",
"arg2_id": "miRNA-corp.d10.s4.e2",
"normalized": []
},
{
"id": "600",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d10.s4.e1",
"arg2_id": "miRNA-corp.d10.s4.e3",
"normalized": []
},
{
"id": "601",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d10.s5.e0",
"arg2_id": "miRNA-corp.d10.s5.e3",
"normalized": []
},
{
"id": "602",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d10.s5.e0",
"arg2_id": "miRNA-corp.d10.s5.e4",
"normalized": []
},
{
"id": "603",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d10.s5.e0",
"arg2_id": "miRNA-corp.d10.s5.e5",
"normalized": []
},
{
"id": "604",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d10.s5.e1",
"arg2_id": "miRNA-corp.d10.s5.e3",
"normalized": []
},
{
"id": "605",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d10.s5.e1",
"arg2_id": "miRNA-corp.d10.s5.e4",
"normalized": []
},
{
"id": "606",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d10.s5.e1",
"arg2_id": "miRNA-corp.d10.s5.e5",
"normalized": []
},
{
"id": "607",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d10.s5.e2",
"arg2_id": "miRNA-corp.d10.s5.e3",
"normalized": []
},
{
"id": "608",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d10.s5.e2",
"arg2_id": "miRNA-corp.d10.s5.e4",
"normalized": []
},
{
"id": "609",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d10.s5.e2",
"arg2_id": "miRNA-corp.d10.s5.e5",
"normalized": []
},
{
"id": "610",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d10.s6.e0",
"arg2_id": "miRNA-corp.d10.s6.e1",
"normalized": []
},
{
"id": "611",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d10.s7.e1",
"arg2_id": "miRNA-corp.d10.s7.e2",
"normalized": []
},
{
"id": "612",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d10.s7.e0",
"arg2_id": "miRNA-corp.d10.s7.e2",
"normalized": []
},
{
"id": "613",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d10.s8.e0",
"arg2_id": "miRNA-corp.d10.s8.e2",
"normalized": []
}
] |
682 | miRNA-corp.d11 | [
{
"id": "615",
"type": "title",
"text": [
"We will describe the evidence that disruption to the REST regulon brought about by a loss of interaction between REST and mutHtt may be a key contributory factor in the widespread dysregulation of gene expression in HD. "
],
"offsets": [
[
0,
222
]
]
},
{
"id": "616",
"type": "abstract",
"text": [
"Transcriptional dysregulation of coding and non-coding genes in cellular models of Huntington's disease. "
],
"offsets": [
[
223,
329
]
]
},
{
"id": "617",
"type": "abstract",
"text": [
"HD (Huntington's disease) is a late onset heritable neurodegenerative disorder that is characterized by neuronal dysfunction and death, particularly in the cerebral cortex and medium spiny neurons of the striatum. "
],
"offsets": [
[
330,
544
]
]
},
{
"id": "618",
"type": "abstract",
"text": [
"This is followed by progressive chorea, dementia and emotional dysfunction, eventually resulting in death. "
],
"offsets": [
[
545,
652
]
]
},
{
"id": "619",
"type": "abstract",
"text": [
"HD is caused by an expanded CAG repeat in the first exon of the HD gene that results in an abnormally elongated polyQ (polyglutamine) tract in its protein product, Htt (Huntingtin). "
],
"offsets": [
[
653,
835
]
]
},
{
"id": "620",
"type": "abstract",
"text": [
"Wild-type Htt is largely cytoplasmic; however, in HD, proteolytic N-terminal fragments of Htt form insoluble deposits in both the cytoplasm and nucleus, provoking the idea that mutHtt (mutant Htt) causes transcriptional dysfunction. "
],
"offsets": [
[
836,
1069
]
]
},
{
"id": "621",
"type": "abstract",
"text": [
"While a number of specific transcription factors and co-factors have been proposed as mediators of mutHtt toxicity, the causal relationship between these Htt/transcription factor interactions and HD pathology remains unknown. "
],
"offsets": [
[
1070,
1296
]
]
},
{
"id": "622",
"type": "abstract",
"text": [
"Previous work has highlighted REST [RE1 (repressor element 1)-silencing transcription factor] as one such transcription factor. "
],
"offsets": [
[
1297,
1425
]
]
},
{
"id": "623",
"type": "abstract",
"text": [
"Recent evidence has also shown that REST regulates transcription of regulatory miRNAs (microRNAs), many of which are known to regulate neuronal gene expression and are dysregulated in HD. Thus repression of miRNAs constitutes a second, indirect mechanism by which REST can alter the neuronal transcriptome in HD. "
],
"offsets": [
[
1426,
1739
]
]
},
{
"id": "624",
"type": "abstract",
"text": [
"Many of its direct target genes are known or suspected to have a role in HD pathogenesis, including BDNF (brain-derived neurotrophic factor). "
],
"offsets": [
[
1740,
1882
]
]
},
{
"id": "625",
"type": "abstract",
"text": [
"REST is a master regulator of neuronal genes, repressing their expression. "
],
"offsets": [
[
1883,
1958
]
]
}
] | [
{
"id": "626",
"type": "Diseases",
"text": [
"HD"
],
"offsets": [
[
216,
218
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d11.s0.e0"
}
]
},
{
"id": "627",
"type": "Genes/Proteins",
"text": [
"REST"
],
"offsets": [
[
53,
57
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d11.s0.e1"
}
]
},
{
"id": "628",
"type": "Genes/Proteins",
"text": [
"REST"
],
"offsets": [
[
113,
117
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d11.s0.e2"
}
]
},
{
"id": "629",
"type": "Relation_Trigger",
"text": [
"dysregulation of gene expression"
],
"offsets": [
[
180,
212
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d11.s0.e3"
}
]
},
{
"id": "630",
"type": "Diseases",
"text": [
"Huntington's disease"
],
"offsets": [
[
306,
326
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d11.s1.e0"
}
]
},
{
"id": "631",
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] | [] | [] | [
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] |
745 | miRNA-corp.d12 | [
{
"id": "683",
"type": "title",
"text": [
"BACKGROUND: The aberrant expression of microRNAs (miRNAs) is associated with a variety of diseases including cancers. "
],
"offsets": [
[
0,
118
]
]
},
{
"id": "684",
"type": "abstract",
"text": [
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],
"offsets": [
[
119,
256
]
]
},
{
"id": "685",
"type": "abstract",
"text": [
"METHODS: We screened the expression profile of 200 miRNAs in a training sample set consisting of 84 astrocytoma samples and 20 normal adjacent tissue (NAT) samples using the method of stem-loop quantitative RT-PCR. "
],
"offsets": [
[
257,
472
]
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{
"id": "686",
"type": "abstract",
"text": [
"The significantly altered miRNAs were validated in another independent sample set consisting of 40 astrocytoma samples and 40 NAT samples. "
],
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[
473,
612
]
]
},
{
"id": "687",
"type": "abstract",
"text": [
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],
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[
613,
818
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]
},
{
"id": "688",
"type": "abstract",
"text": [
"RESULTS: After a two-phase selection and validation process, seven miRNAs were found to have a significantly different expression profile in astrocytoma samples upon comparison to the NAT samples. "
],
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819,
1016
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]
},
{
"id": "689",
"type": "abstract",
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1017,
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{
"id": "690",
"type": "abstract",
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],
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1170,
1295
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{
"id": "691",
"type": "abstract",
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1296,
1391
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{
"id": "692",
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1392,
1582
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{
"id": "693",
"type": "abstract",
"text": [
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],
"offsets": [
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1583,
1801
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"id": "708",
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{
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886,
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}
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},
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"id": "711",
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"tumours"
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"id": "713",
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},
{
"id": "714",
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},
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"id": "715",
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}
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"id": "716",
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1193,
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{
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{
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}
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},
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"id": "730",
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1741,
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"db_id": "miRNA-corp.d12.s10.e1"
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]
}
] | [] | [] | [
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{
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{
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}
] |
798 | miRNA-corp.d13 | [
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441,
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{
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1335,
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},
{
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1193,
1204
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},
{
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1264,
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1426,
1460
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{
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1462,
1466
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{
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1472,
1475
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},
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1504,
1506
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{
"id": "784",
"type": "Relation_Trigger",
"text": [
"downregulation"
],
"offsets": [
[
1486,
1500
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d13.s9.e6"
}
]
},
{
"id": "785",
"type": "Relation_Trigger",
"text": [
"regulatory"
],
"offsets": [
[
1364,
1374
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d13.s9.e7"
}
]
},
{
"id": "786",
"type": "Relation_Trigger",
"text": [
"co-regulated"
],
"offsets": [
[
1386,
1398
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d13.s9.e8"
}
]
}
] | [] | [] | [
{
"id": "787",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d13.s0.e0",
"arg2_id": "miRNA-corp.d13.s0.e1",
"normalized": []
},
{
"id": "788",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d13.s6.e0",
"arg2_id": "miRNA-corp.d13.s6.e1",
"normalized": []
},
{
"id": "789",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d13.s8.e0",
"arg2_id": "miRNA-corp.d13.s8.e1",
"normalized": []
},
{
"id": "790",
"type": "Non-Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d13.s9.e0",
"arg2_id": "miRNA-corp.d13.s9.e2",
"normalized": []
},
{
"id": "791",
"type": "Non-Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d13.s9.e0",
"arg2_id": "miRNA-corp.d13.s9.e3",
"normalized": []
},
{
"id": "792",
"type": "Non-Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d13.s9.e0",
"arg2_id": "miRNA-corp.d13.s9.e4",
"normalized": []
},
{
"id": "793",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d13.s9.e0",
"arg2_id": "miRNA-corp.d13.s9.e5",
"normalized": []
},
{
"id": "794",
"type": "Non-Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d13.s9.e1",
"arg2_id": "miRNA-corp.d13.s9.e2",
"normalized": []
},
{
"id": "795",
"type": "Non-Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d13.s9.e1",
"arg2_id": "miRNA-corp.d13.s9.e3",
"normalized": []
},
{
"id": "796",
"type": "Non-Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d13.s9.e1",
"arg2_id": "miRNA-corp.d13.s9.e4",
"normalized": []
},
{
"id": "797",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d13.s9.e1",
"arg2_id": "miRNA-corp.d13.s9.e5",
"normalized": []
}
] |
821 | miRNA-corp.d14 | [
{
"id": "799",
"type": "title",
"text": [
"To determine the role of possible pathogenic cofactors such as geographic, ethnic, genetic, and cultural features, further pertinent surveys are required in subtropical northwestern Argentina. "
],
"offsets": [
[
0,
195
]
]
},
{
"id": "800",
"type": "abstract",
"text": [
"Considering the HAM/TSP cluster described here plus previously reported isolated cases in neighboring Salta Province, we speculate that the Puna Jujeña region and regions in that vicinity would be a microepidemic focus of disease. "
],
"offsets": [
[
196,
427
]
]
},
{
"id": "801",
"type": "abstract",
"text": [
"No history of risk factors was disclosed, except for a single transfusion in 1 patient. "
],
"offsets": [
[
428,
516
]
]
},
{
"id": "802",
"type": "abstract",
"text": [
"Most patients (9/11) were born in Cochinoca Department, located in an Andes highland area called Puna Jujeña, situated at more that 3400 m above sea level. "
],
"offsets": [
[
517,
673
]
]
},
{
"id": "803",
"type": "abstract",
"text": [
"Accordingly, a clinically diagnosed and serologically confirmed cluster of cases in 1 man and 10 women, including 2 sisters, is described here. "
],
"offsets": [
[
674,
818
]
]
},
{
"id": "804",
"type": "abstract",
"text": [
"Compared with other regions in Argentina, greater human T-cell lymphotropic virus type I (HTLV-I) seroprevalence has been reported in Jujuy Province, where it reaches 2.32% in the general population, so that a search for HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP) cases deserved to be carried out. "
],
"offsets": [
[
819,
1142
]
]
},
{
"id": "805",
"type": "abstract",
"text": [
"A cluster of human T-cell lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis in Jujuy, Argentina. "
],
"offsets": [
[
1143,
1268
]
]
}
] | [
{
"id": "806",
"type": "Species",
"text": [
"ethnic"
],
"offsets": [
[
75,
81
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d14.s0.e0"
}
]
},
{
"id": "807",
"type": "Diseases",
"text": [
"HAM"
],
"offsets": [
[
212,
215
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d14.s1.e0"
}
]
},
{
"id": "808",
"type": "Diseases",
"text": [
"TSP"
],
"offsets": [
[
216,
219
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d14.s1.e1"
}
]
},
{
"id": "809",
"type": "Species",
"text": [
"patient"
],
"offsets": [
[
507,
514
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d14.s4.e0"
}
]
},
{
"id": "810",
"type": "Species",
"text": [
"patients"
],
"offsets": [
[
522,
530
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d14.s5.e0"
}
]
},
{
"id": "811",
"type": "Species",
"text": [
"man"
],
"offsets": [
[
760,
763
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d14.s6.e0"
}
]
},
{
"id": "812",
"type": "Species",
"text": [
"women"
],
"offsets": [
[
771,
776
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d14.s6.e1"
}
]
},
{
"id": "813",
"type": "Species",
"text": [
"human"
],
"offsets": [
[
869,
874
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d14.s7.e0"
}
]
},
{
"id": "814",
"type": "Diseases",
"text": [
"HTLV-I-associated myelopathy"
],
"offsets": [
[
1040,
1068
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d14.s7.e1"
}
]
},
{
"id": "815",
"type": "Diseases",
"text": [
"tropical spastic paraparesis"
],
"offsets": [
[
1069,
1097
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d14.s7.e2"
}
]
},
{
"id": "816",
"type": "Diseases",
"text": [
"HAM"
],
"offsets": [
[
1099,
1102
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d14.s7.e3"
}
]
},
{
"id": "817",
"type": "Diseases",
"text": [
"TSP"
],
"offsets": [
[
1103,
1106
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d14.s7.e4"
}
]
},
{
"id": "818",
"type": "Diseases",
"text": [
"human T-cell lymphotropic virus type I-associated myelopathy"
],
"offsets": [
[
1156,
1216
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d14.s8.e0"
}
]
},
{
"id": "819",
"type": "Diseases",
"text": [
"tropical spastic paraparesis"
],
"offsets": [
[
1217,
1245
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d14.s8.e1"
}
]
},
{
"id": "820",
"type": "Species",
"text": [
"human"
],
"offsets": [
[
1156,
1161
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d14.s8.e2"
}
]
}
] | [] | [] | [] |
842 | miRNA-corp.d15 | [
{
"id": "822",
"type": "abstract",
"text": [
"OBJECTIVE: : To compare presentation of Alzheimer disease (AD) at the time of initial evaluation at a university specialty clinic across three ethnoracial groups in order to understand similarities and differences in the demographic, clinical, cognitive, psychiatric, and biologic features. "
],
"offsets": [
[
0,
291
]
]
},
{
"id": "823",
"type": "abstract",
"text": [
"Ethnoracial differences in the clinical characteristics of Alzheimer's disease at initial presentation at an urban Alzheimer's disease center. "
],
"offsets": [
[
292,
436
]
]
},
{
"id": "824",
"type": "abstract",
"text": [
"The apolipoprotein E-4 genotype was not associated with AD in the Latino cohort. "
],
"offsets": [
[
437,
518
]
]
},
{
"id": "825",
"type": "abstract",
"text": [
"There was more depression in the Latinos compared with African Americans and WNHs. "
],
"offsets": [
[
519,
602
]
]
},
{
"id": "826",
"type": "abstract",
"text": [
"In particular, the largely immigrant Puerto Rican Latino group had an earlier age of onset of AD, more cognitive impairment, and greater severity of cognitive impairment at the time of initial evaluation in the setting of low average education and socioeconomic status. "
],
"offsets": [
[
603,
873
]
]
},
{
"id": "827",
"type": "abstract",
"text": [
"MEASUREMENTS: : Demographic variables and age of onset of AD, as well as cognitive, functional, and mood impairments at the time of initial presentation and frequencies of apolipoprotein E genotypes, were compared across groups. "
],
"offsets": [
[
874,
1103
]
]
},
{
"id": "828",
"type": "abstract",
"text": [
"CONCLUSIONS: : Minority groups in Philadelphia, especially Latinos, exhibit a more severe profile of AD at the time of presentation than WNHs. "
],
"offsets": [
[
1104,
1247
]
]
}
] | [
{
"id": "829",
"type": "Diseases",
"text": [
"Alzheimer disease"
],
"offsets": [
[
40,
57
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d15.s1.e0"
}
]
},
{
"id": "830",
"type": "Diseases",
"text": [
"AD"
],
"offsets": [
[
59,
61
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d15.s1.e1"
}
]
},
{
"id": "831",
"type": "Diseases",
"text": [
"Alzheimer's disease"
],
"offsets": [
[
351,
370
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d15.s2.e0"
}
]
},
{
"id": "832",
"type": "Diseases",
"text": [
"AD"
],
"offsets": [
[
493,
495
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d15.s3.e0"
}
]
},
{
"id": "833",
"type": "Genes/Proteins",
"text": [
"apolipoprotein E"
],
"offsets": [
[
441,
457
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d15.s3.e1"
}
]
},
{
"id": "834",
"type": "Diseases",
"text": [
"depression"
],
"offsets": [
[
534,
544
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d15.s5.e0"
}
]
},
{
"id": "835",
"type": "Diseases",
"text": [
"cognitive impairment"
],
"offsets": [
[
706,
726
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d15.s6.e0"
}
]
},
{
"id": "836",
"type": "Diseases",
"text": [
"cognitive impairment"
],
"offsets": [
[
752,
772
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d15.s6.e1"
}
]
},
{
"id": "837",
"type": "Diseases",
"text": [
"AD"
],
"offsets": [
[
697,
699
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d15.s6.e2"
}
]
},
{
"id": "838",
"type": "Relation_Trigger",
"text": [
"impairments"
],
"offsets": [
[
979,
990
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d15.s8.e0"
}
]
},
{
"id": "839",
"type": "Diseases",
"text": [
"AD"
],
"offsets": [
[
932,
934
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d15.s8.e1"
}
]
},
{
"id": "840",
"type": "Genes/Proteins",
"text": [
"apolipoprotein E"
],
"offsets": [
[
1046,
1062
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d15.s8.e2"
}
]
},
{
"id": "841",
"type": "Diseases",
"text": [
"AD"
],
"offsets": [
[
1205,
1207
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d15.s11.e0"
}
]
}
] | [] | [] | [] |
879 | miRNA-corp.d16 | [
{
"id": "843",
"type": "title",
"text": [
"Furthermore, methods to profile miRNAs from formalin-fixed, paraffin-embedded (FFPE) archival tissues or to study their cellular and subcellular localization in FFPE tissues have been lacking. "
],
"offsets": [
[
0,
193
]
]
},
{
"id": "844",
"type": "abstract",
"text": [
"Here we report the coordinated miRNA expression analysis from the tissue level to the subcellular level, using the RAKE (RNA-primed, array-based, Klenow Enzyme) miRNA microarray platform in conjunction with Locked Nucleic Acid (LNA)-based in situ hybridization (LNA-ISH) on archival FFPE human brains and oligodendroglial tumors. "
],
"offsets": [
[
194,
524
]
]
},
{
"id": "845",
"type": "abstract",
"text": [
"The ability to profile miRNAs from archival tissues at the tissue level, by RAKE microarrays, and at the cellular level by LNA-ISH, will accelerate studies of miRNAs in human diseases. "
],
"offsets": [
[
525,
712
]
]
},
{
"id": "846",
"type": "abstract",
"text": [
"RAKE and LNA-ISH reveal microRNA expression and localization in archival human brain. "
],
"offsets": [
[
713,
800
]
]
},
{
"id": "847",
"type": "abstract",
"text": [
"microRNAs (miRNAs) are small (approximately 22 nucleotide) regulatory RNAs which play fundamental roles in many biological processes. "
],
"offsets": [
[
801,
935
]
]
},
{
"id": "848",
"type": "abstract",
"text": [
"Recent studies have shown that the expression of many miRNAs is altered in various human tumors and some miRNAs may function as oncogenes or tumor suppressor genes. "
],
"offsets": [
[
936,
1101
]
]
},
{
"id": "849",
"type": "abstract",
"text": [
"However, with the exception of glioblastoma multiforme, the expression of miRNAs in brain tumors is unknown. "
],
"offsets": [
[
1102,
1211
]
]
}
] | [
{
"id": "850",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
[
32,
38
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d16.s0.e0"
}
]
},
{
"id": "851",
"type": "Non-Specific_miRNAs",
"text": [
"miRNA"
],
"offsets": [
[
225,
230
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d16.s1.e0"
}
]
},
{
"id": "852",
"type": "Non-Specific_miRNAs",
"text": [
"miRNA"
],
"offsets": [
[
355,
360
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d16.s1.e1"
}
]
},
{
"id": "853",
"type": "Diseases",
"text": [
"oligodendroglial tumors"
],
"offsets": [
[
499,
522
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d16.s1.e2"
}
]
},
{
"id": "854",
"type": "Species",
"text": [
"human"
],
"offsets": [
[
482,
487
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d16.s1.e3"
}
]
},
{
"id": "855",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
[
548,
554
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d16.s2.e0"
}
]
},
{
"id": "856",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
[
684,
690
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d16.s2.e1"
}
]
},
{
"id": "857",
"type": "Species",
"text": [
"human"
],
"offsets": [
[
694,
699
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d16.s2.e2"
}
]
},
{
"id": "858",
"type": "Relation_Trigger",
"text": [
"accelerate"
],
"offsets": [
[
662,
672
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d16.s2.e3"
}
]
},
{
"id": "859",
"type": "Non-Specific_miRNAs",
"text": [
"microRNA"
],
"offsets": [
[
737,
745
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d16.s3.e0"
}
]
},
{
"id": "860",
"type": "Species",
"text": [
"human"
],
"offsets": [
[
786,
791
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d16.s3.e1"
}
]
},
{
"id": "861",
"type": "Non-Specific_miRNAs",
"text": [
"microRNAs"
],
"offsets": [
[
801,
810
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d16.s4.e0"
}
]
},
{
"id": "862",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
[
812,
818
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d16.s4.e1"
}
]
},
{
"id": "863",
"type": "Relation_Trigger",
"text": [
"regulatory"
],
"offsets": [
[
860,
870
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d16.s4.e2"
}
]
},
{
"id": "864",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
[
990,
996
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d16.s5.e0"
}
]
},
{
"id": "865",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
[
1041,
1047
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d16.s5.e1"
}
]
},
{
"id": "866",
"type": "Relation_Trigger",
"text": [
"expression of many miRNAs is altered"
],
"offsets": [
[
971,
1007
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d16.s5.e2"
}
]
},
{
"id": "867",
"type": "Diseases",
"text": [
"tumors"
],
"offsets": [
[
1025,
1031
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d16.s5.e3"
}
]
},
{
"id": "868",
"type": "Relation_Trigger",
"text": [
"tumor suppressor"
],
"offsets": [
[
1077,
1093
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d16.s5.e4"
}
]
},
{
"id": "869",
"type": "Species",
"text": [
"human"
],
"offsets": [
[
1019,
1024
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d16.s5.e5"
}
]
},
{
"id": "870",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
[
1176,
1182
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d16.s6.e0"
}
]
},
{
"id": "871",
"type": "Diseases",
"text": [
"glioblastoma multiforme"
],
"offsets": [
[
1133,
1156
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d16.s6.e1"
}
]
},
{
"id": "872",
"type": "Diseases",
"text": [
"brain tumors"
],
"offsets": [
[
1186,
1198
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d16.s6.e2"
}
]
}
] | [] | [] | [
{
"id": "873",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d16.s1.e0",
"arg2_id": "miRNA-corp.d16.s1.e2",
"normalized": []
},
{
"id": "874",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d16.s1.e1",
"arg2_id": "miRNA-corp.d16.s1.e2",
"normalized": []
},
{
"id": "875",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d16.s5.e0",
"arg2_id": "miRNA-corp.d16.s5.e3",
"normalized": []
},
{
"id": "876",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d16.s5.e1",
"arg2_id": "miRNA-corp.d16.s5.e3",
"normalized": []
},
{
"id": "877",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d16.s6.e0",
"arg2_id": "miRNA-corp.d16.s6.e1",
"normalized": []
},
{
"id": "878",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d16.s6.e0",
"arg2_id": "miRNA-corp.d16.s6.e2",
"normalized": []
}
] |
917 | miRNA-corp.d17 | [
{
"id": "880",
"type": "title",
"text": [
"Plasma concentrations of miR-124 were significantly elevated at 6 h, and remained elevated at 48 h after MCAO introduction. "
],
"offsets": [
[
0,
124
]
]
},
{
"id": "881",
"type": "abstract",
"text": [
"Thus, plasma concentration of miR-124 provides a promising candidate biomarker for early detection of cerebral infarction. "
],
"offsets": [
[
125,
250
]
]
},
{
"id": "882",
"type": "abstract",
"text": [
"In this study, miRNA array analysis in various tissues showed that miR-124 is almost exclusively expressed in the central nervous system and neuronal cells, suggesting that it might be useful as a potential biomarker for neurological diseases. "
],
"offsets": [
[
251,
495
]
]
},
{
"id": "883",
"type": "abstract",
"text": [
"We examined whether plasma concentrations of brain-specific miRNA can serve as a biomarker for cerebral infarction, where the cerebral infarction was modeled by middle cerebral artery occlusion (MCAO) in the rat. "
],
"offsets": [
[
496,
709
]
]
},
{
"id": "884",
"type": "abstract",
"text": [
"MicroRNAs (miRNAs) are endogenous small RNAs that play an important role in various physiological processes by downregulating target genes. "
],
"offsets": [
[
710,
850
]
]
},
{
"id": "885",
"type": "abstract",
"text": [
"Recently, plasma miRNAs have been investigated as biomarkers for various diseases. "
],
"offsets": [
[
851,
934
]
]
},
{
"id": "886",
"type": "abstract",
"text": [
"Plasma miR-124 as a biomarker for cerebral infarction. "
],
"offsets": [
[
935,
991
]
]
}
] | [
{
"id": "887",
"type": "Specific_miRNAs",
"text": [
"miR-124"
],
"offsets": [
[
25,
32
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d17.s0.e0"
}
]
},
{
"id": "888",
"type": "Diseases",
"text": [
"MCAO"
],
"offsets": [
[
105,
109
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d17.s0.e1"
}
]
},
{
"id": "889",
"type": "Relation_Trigger",
"text": [
"concentrations of miR-124 were significantly elevated"
],
"offsets": [
[
7,
60
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d17.s0.e2"
}
]
},
{
"id": "890",
"type": "Diseases",
"text": [
"cerebral infarction"
],
"offsets": [
[
227,
246
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d17.s1.e0"
}
]
},
{
"id": "891",
"type": "Specific_miRNAs",
"text": [
"miR-124"
],
"offsets": [
[
155,
162
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d17.s1.e1"
}
]
},
{
"id": "892",
"type": "Non-Specific_miRNAs",
"text": [
"miRNA"
],
"offsets": [
[
266,
271
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d17.s2.e0"
}
]
},
{
"id": "893",
"type": "Specific_miRNAs",
"text": [
"miR-124"
],
"offsets": [
[
318,
325
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d17.s2.e1"
}
]
},
{
"id": "894",
"type": "Diseases",
"text": [
"neurological diseases"
],
"offsets": [
[
472,
493
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d17.s2.e2"
}
]
},
{
"id": "895",
"type": "Diseases",
"text": [
"cerebral infarction"
],
"offsets": [
[
591,
610
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d17.s3.e0"
}
]
},
{
"id": "896",
"type": "Diseases",
"text": [
"cerebral infarction"
],
"offsets": [
[
622,
641
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d17.s3.e1"
}
]
},
{
"id": "897",
"type": "Non-Specific_miRNAs",
"text": [
"miRNA"
],
"offsets": [
[
556,
561
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d17.s3.e2"
}
]
},
{
"id": "898",
"type": "Diseases",
"text": [
"middle cerebral artery occlusion"
],
"offsets": [
[
657,
689
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d17.s3.e3"
}
]
},
{
"id": "899",
"type": "Diseases",
"text": [
"MCAO"
],
"offsets": [
[
691,
695
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d17.s3.e4"
}
]
},
{
"id": "900",
"type": "Species",
"text": [
"rat"
],
"offsets": [
[
704,
707
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d17.s3.e5"
}
]
},
{
"id": "901",
"type": "Non-Specific_miRNAs",
"text": [
"MicroRNAs"
],
"offsets": [
[
710,
719
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d17.s4.e0"
}
]
},
{
"id": "902",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
[
721,
727
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d17.s4.e1"
}
]
},
{
"id": "903",
"type": "Relation_Trigger",
"text": [
"downregulating"
],
"offsets": [
[
821,
835
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d17.s4.e2"
}
]
},
{
"id": "904",
"type": "Relation_Trigger",
"text": [
"target"
],
"offsets": [
[
836,
842
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d17.s4.e3"
}
]
},
{
"id": "905",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
[
868,
874
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d17.s5.e0"
}
]
},
{
"id": "906",
"type": "Diseases",
"text": [
"cerebral infarction"
],
"offsets": [
[
969,
988
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d17.s6.e0"
}
]
},
{
"id": "907",
"type": "Specific_miRNAs",
"text": [
"miR-124"
],
"offsets": [
[
942,
949
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d17.s6.e1"
}
]
}
] | [] | [] | [
{
"id": "908",
"type": "Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d17.s0.e0",
"arg2_id": "miRNA-corp.d17.s0.e1",
"normalized": []
},
{
"id": "909",
"type": "Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d17.s1.e1",
"arg2_id": "miRNA-corp.d17.s1.e0",
"normalized": []
},
{
"id": "910",
"type": "Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d17.s2.e1",
"arg2_id": "miRNA-corp.d17.s2.e2",
"normalized": []
},
{
"id": "911",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d17.s2.e0",
"arg2_id": "miRNA-corp.d17.s2.e2",
"normalized": []
},
{
"id": "912",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d17.s3.e2",
"arg2_id": "miRNA-corp.d17.s3.e0",
"normalized": []
},
{
"id": "913",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d17.s3.e2",
"arg2_id": "miRNA-corp.d17.s3.e3",
"normalized": []
},
{
"id": "914",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d17.s3.e2",
"arg2_id": "miRNA-corp.d17.s3.e4",
"normalized": []
},
{
"id": "915",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d17.s3.e2",
"arg2_id": "miRNA-corp.d17.s3.e1",
"normalized": []
},
{
"id": "916",
"type": "Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d17.s6.e1",
"arg2_id": "miRNA-corp.d17.s6.e0",
"normalized": []
}
] |
937 | miRNA-corp.d18 | [
{
"id": "918",
"type": "abstract",
"text": [
"CONCLUSIONS: An earlier age at symptom onset suggests that US mainland Latino individuals may experience an increased burden of AD compared with Anglo individuals. "
],
"offsets": [
[
0,
164
]
]
},
{
"id": "919",
"type": "abstract",
"text": [
"OBJECTIVE: To compare the age at AD symptom onset in Latino and Anglo individuals. "
],
"offsets": [
[
165,
248
]
]
},
{
"id": "920",
"type": "abstract",
"text": [
"BACKGROUND: Latino individuals are the largest minority group and the fastest growing population group in the United States, yet there are few studies comparing the clinical features of Alzheimer disease (AD) in this population with those found in Anglo (white non-Latino) patients. "
],
"offsets": [
[
249,
532
]
]
},
{
"id": "921",
"type": "abstract",
"text": [
"Earlier onset of Alzheimer disease symptoms in latino individuals compared with anglo individuals. "
],
"offsets": [
[
533,
633
]
]
},
{
"id": "922",
"type": "abstract",
"text": [
"RESULTS: After adjusting for center, sex, and years of education, Latino patients had a mean age at symptom onset 6.8 years earlier (95% confidence interval, 3.5-10.3 years earlier) than Anglo patients. "
],
"offsets": [
[
634,
837
]
]
},
{
"id": "923",
"type": "abstract",
"text": [
"PATIENTS: We evaluated 119 Latino and 55 Anglo patients who had a diagnosis of AD. MAIN OUTCOME MEASURE: Age at symptom onset. "
],
"offsets": [
[
838,
965
]
]
},
{
"id": "924",
"type": "abstract",
"text": [
"DESIGN: Cross-sectional assessment using standardized methods to collect and compare age at AD symptom onset, demographic variables, and medical variables. "
],
"offsets": [
[
966,
1122
]
]
}
] | [
{
"id": "925",
"type": "Diseases",
"text": [
"AD"
],
"offsets": [
[
128,
130
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d18.s1.e0"
}
]
},
{
"id": "926",
"type": "Diseases",
"text": [
"AD"
],
"offsets": [
[
198,
200
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d18.s2.e0"
}
]
},
{
"id": "927",
"type": "Diseases",
"text": [
"Alzheimer disease"
],
"offsets": [
[
435,
452
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d18.s3.e0"
}
]
},
{
"id": "928",
"type": "Diseases",
"text": [
"AD"
],
"offsets": [
[
454,
456
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d18.s3.e1"
}
]
},
{
"id": "929",
"type": "Species",
"text": [
"patients"
],
"offsets": [
[
522,
530
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d18.s3.e2"
}
]
},
{
"id": "930",
"type": "Diseases",
"text": [
"Alzheimer disease"
],
"offsets": [
[
550,
567
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d18.s4.e0"
}
]
},
{
"id": "931",
"type": "Species",
"text": [
"patients"
],
"offsets": [
[
707,
715
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d18.s5.e0"
}
]
},
{
"id": "932",
"type": "Species",
"text": [
"patients"
],
"offsets": [
[
827,
835
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d18.s5.e0"
}
]
},
{
"id": "933",
"type": "Diseases",
"text": [
"AD"
],
"offsets": [
[
917,
919
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d18.s6.e0"
}
]
},
{
"id": "934",
"type": "Species",
"text": [
"PATIENTS"
],
"offsets": [
[
838,
846
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d18.s6.e1"
}
]
},
{
"id": "935",
"type": "Species",
"text": [
"patients"
],
"offsets": [
[
885,
893
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d18.s6.e2"
}
]
},
{
"id": "936",
"type": "Diseases",
"text": [
"AD"
],
"offsets": [
[
1058,
1060
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d18.s8.e0"
}
]
}
] | [] | [] | [] |
1036 | miRNA-corp.d19 | [
{
"id": "938",
"type": "title",
"text": [
"We conclude that miR-17/92 is a positive effector of Shh-mediated proliferation and that aberrant expression/amplification of this miR confers a growth advantage to medulloblastomas. "
],
"offsets": [
[
0,
185
]
]
},
{
"id": "939",
"type": "abstract",
"text": [
"Ectopic miR-17/92 expression in CGNPs synergized with exogenous Shh to increase proliferation and also enabled them to proliferate in the absence of Shh. "
],
"offsets": [
[
186,
340
]
]
},
{
"id": "940",
"type": "abstract",
"text": [
"In CGNPs, the Shh effector N-myc, but not Gli1, induced miR-17/92 expression. "
],
"offsets": [
[
341,
419
]
]
},
{
"id": "941",
"type": "abstract",
"text": [
"Consistent with its regulation by Shh, we observed that Shh treatment of primary cerebellar granule neuron precursors (CGNP), proposed cells of origin for the Shh-associated medulloblastomas, resulted in increased miR-17/92 expression. "
],
"offsets": [
[
420,
656
]
]
},
{
"id": "942",
"type": "abstract",
"text": [
"Medulloblastomas in which miR-17/92 was up-regulated also had elevated levels of MYC/MYCN expression. "
],
"offsets": [
[
657,
759
]
]
},
{
"id": "943",
"type": "abstract",
"text": [
"Expression of miR-17/92 was highest in the subgroup of medulloblastomas associated with activation of the sonic hedgehog (Shh) signaling pathway compared with other subgroups of medulloblastoma. "
],
"offsets": [
[
760,
955
]
]
},
{
"id": "944",
"type": "abstract",
"text": [
"Profiling the expression of 427 mature microRNAs (miRNA) in a series of 90 primary human medulloblastomas revealed that components of the miR-17/92 polycistron are the most highly up-regulated miRNAs in medulloblastoma. "
],
"offsets": [
[
956,
1176
]
]
},
{
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},
{
"id": "1019",
"type": "Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d19.s5.e0",
"arg2_id": "miRNA-corp.d19.s5.e2",
"normalized": []
},
{
"id": "1020",
"type": "Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d19.s5.e0",
"arg2_id": "miRNA-corp.d19.s5.e6",
"normalized": []
},
{
"id": "1021",
"type": "Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d19.s5.e0",
"arg2_id": "miRNA-corp.d19.s5.e7",
"normalized": []
},
{
"id": "1022",
"type": "Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d19.s6.e0",
"arg2_id": "miRNA-corp.d19.s6.e1",
"normalized": []
},
{
"id": "1023",
"type": "Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d19.s6.e0",
"arg2_id": "miRNA-corp.d19.s6.e5",
"normalized": []
},
{
"id": "1024",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d19.s6.e2",
"arg2_id": "miRNA-corp.d19.s6.e1",
"normalized": []
},
{
"id": "1025",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d19.s6.e2",
"arg2_id": "miRNA-corp.d19.s6.e5",
"normalized": []
},
{
"id": "1026",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d19.s6.e3",
"arg2_id": "miRNA-corp.d19.s6.e1",
"normalized": []
},
{
"id": "1027",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d19.s6.e3",
"arg2_id": "miRNA-corp.d19.s6.e5",
"normalized": []
},
{
"id": "1028",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d19.s6.e4",
"arg2_id": "miRNA-corp.d19.s6.e1",
"normalized": []
},
{
"id": "1029",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d19.s6.e4",
"arg2_id": "miRNA-corp.d19.s6.e5",
"normalized": []
},
{
"id": "1030",
"type": "Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d19.s7.e0",
"arg2_id": "miRNA-corp.d19.s7.e2",
"normalized": []
},
{
"id": "1031",
"type": "Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d19.s7.e0",
"arg2_id": "miRNA-corp.d19.s7.e3",
"normalized": []
},
{
"id": "1032",
"type": "Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d19.s9.e0",
"arg2_id": "miRNA-corp.d19.s9.e1",
"normalized": []
},
{
"id": "1033",
"type": "Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d19.s9.e0",
"arg2_id": "miRNA-corp.d19.s9.e2",
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},
{
"id": "1034",
"type": "Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d19.s9.e0",
"arg2_id": "miRNA-corp.d19.s9.e3",
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},
{
"id": "1035",
"type": "Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d19.s9.e0",
"arg2_id": "miRNA-corp.d19.s9.e5",
"normalized": []
}
] |
1093 | miRNA-corp.d20 | [
{
"id": "1037",
"type": "title",
"text": [
"MicroRNA regulation of IFN-beta protein expression: rapid and sensitive modulation of the innate immune response. "
],
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0,
115
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]
},
{
"id": "1038",
"type": "abstract",
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"In primary primate macrophages, the main cell type implicated in HIV and SIV infection in the CNS, specific miRNAs reduce, whereas miRNA inhibitors enhance, IFN-beta protein production. "
],
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116,
302
]
]
},
{
"id": "1039",
"type": "abstract",
"text": [
"The potential biologic significance of this regulation is supported by evidence of an apparent negative feedback loop, with increased expression of three IFN-beta-regulating miRNAs by primate macrophages exposed to recombinant IFN-beta or stimulated to produce IFN-beta. "
],
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303,
574
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]
},
{
"id": "1040",
"type": "abstract",
"text": [
"Thus, miRNAs may contribute significantly to the regulation of IFN-beta in innate immune responses. "
],
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575,
677
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]
},
{
"id": "1041",
"type": "abstract",
"text": [
"IFN-beta production is an inaugural event in the innate immune response to viral infections, with relatively small fold changes in IFN-beta expression resulting in the activation of important antiviral signaling cascades. "
],
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678,
900
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]
},
{
"id": "1042",
"type": "abstract",
"text": [
"In our rapid SIV/macaque model of HIV encephalitis, the virus enters the CNS within 4 d of infection, accompanied by a marked IFN-beta response that wanes as SIV replication is controlled. "
],
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901,
1090
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]
},
{
"id": "1043",
"type": "abstract",
"text": [
"The centrality of IFN-beta to the innate antiviral response in the CNS combines with the potential inflammatory damage associated with long-term activation of this pathway to suggest that IFN-beta may be subject to regulatory fine-tuning in addition to well-established transcriptional and message stability mechanisms of regulation. "
],
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1091,
1425
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]
},
{
"id": "1044",
"type": "abstract",
"text": [
"In this paper, we present for the first time evidence that microRNAs (miRNAs), including miR-26a, -34a, -145, and let-7b, may directly regulate IFN-beta in human and macaque cells. "
],
"offsets": [
[
1426,
1607
]
]
}
] | [
{
"id": "1045",
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23,
31
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},
{
"id": "1046",
"type": "Non-Specific_miRNAs",
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"MicroRNA"
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0,
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},
{
"id": "1047",
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"modulation"
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72,
82
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]
},
{
"id": "1048",
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"regulation of IFN-beta protein expression"
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9,
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]
},
{
"id": "1049",
"type": "Genes/Proteins",
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"IFN-beta"
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273,
281
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]
},
{
"id": "1050",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
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224,
230
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{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d20.s1.e1"
}
]
},
{
"id": "1051",
"type": "Relation_Trigger",
"text": [
"inhibitors"
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253,
263
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{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d20.s1.e2"
}
]
},
{
"id": "1052",
"type": "Diseases",
"text": [
"HIV and SIV infection"
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[
181,
202
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],
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"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d20.s1.e3"
}
]
},
{
"id": "1053",
"type": "Genes/Proteins",
"text": [
"IFN-beta"
],
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564,
572
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],
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"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d20.s2.e0"
}
]
},
{
"id": "1054",
"type": "Genes/Proteins",
"text": [
"IFN-beta"
],
"offsets": [
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530,
538
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],
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{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d20.s2.e1"
}
]
},
{
"id": "1055",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
[
477,
483
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d20.s2.e2"
}
]
},
{
"id": "1056",
"type": "Genes/Proteins",
"text": [
"IFN-beta"
],
"offsets": [
[
457,
465
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],
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{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d20.s2.e3"
}
]
},
{
"id": "1057",
"type": "Relation_Trigger",
"text": [
"increased expression"
],
"offsets": [
[
427,
447
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],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d20.s2.e4"
}
]
},
{
"id": "1058",
"type": "Relation_Trigger",
"text": [
"regulation"
],
"offsets": [
[
347,
357
]
],
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{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d20.s2.e5"
}
]
},
{
"id": "1059",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
[
581,
587
]
],
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{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d20.s3.e0"
}
]
},
{
"id": "1060",
"type": "Genes/Proteins",
"text": [
"IFN-beta"
],
"offsets": [
[
638,
646
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d20.s3.e1"
}
]
},
{
"id": "1061",
"type": "Relation_Trigger",
"text": [
"regulation"
],
"offsets": [
[
624,
634
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d20.s3.e2"
}
]
},
{
"id": "1062",
"type": "Genes/Proteins",
"text": [
"IFN-beta"
],
"offsets": [
[
678,
686
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d20.s4.e0"
}
]
},
{
"id": "1063",
"type": "Genes/Proteins",
"text": [
"IFN-beta"
],
"offsets": [
[
809,
817
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d20.s4.e1"
}
]
},
{
"id": "1064",
"type": "Relation_Trigger",
"text": [
"activation"
],
"offsets": [
[
846,
856
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],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d20.s4.e2"
}
]
},
{
"id": "1065",
"type": "Diseases",
"text": [
"viral infections"
],
"offsets": [
[
753,
769
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d20.s4.e3"
}
]
},
{
"id": "1066",
"type": "Diseases",
"text": [
"HIV encephalitis"
],
"offsets": [
[
935,
951
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d20.s5.e0"
}
]
},
{
"id": "1067",
"type": "Genes/Proteins",
"text": [
"IFN-beta"
],
"offsets": [
[
1027,
1035
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],
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{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d20.s5.e1"
}
]
},
{
"id": "1068",
"type": "Diseases",
"text": [
"infection"
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[
992,
1001
]
],
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{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d20.s5.e2"
}
]
},
{
"id": "1069",
"type": "Genes/Proteins",
"text": [
"IFN-beta"
],
"offsets": [
[
1109,
1117
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d20.s6.e0"
}
]
},
{
"id": "1070",
"type": "Genes/Proteins",
"text": [
"IFN-beta"
],
"offsets": [
[
1279,
1287
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d20.s6.e1"
}
]
},
{
"id": "1071",
"type": "Relation_Trigger",
"text": [
"associated"
],
"offsets": [
[
1210,
1220
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d20.s6.e2"
}
]
},
{
"id": "1072",
"type": "Relation_Trigger",
"text": [
"activation"
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"offsets": [
[
1236,
1246
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d20.s6.e3"
}
]
},
{
"id": "1073",
"type": "Relation_Trigger",
"text": [
"regulatory"
],
"offsets": [
[
1306,
1316
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d20.s6.e4"
}
]
},
{
"id": "1074",
"type": "Relation_Trigger",
"text": [
"regulation"
],
"offsets": [
[
1413,
1423
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d20.s6.e5"
}
]
},
{
"id": "1075",
"type": "Specific_miRNAs",
"text": [
"let-7b"
],
"offsets": [
[
1540,
1546
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d20.s7.e0"
}
]
},
{
"id": "1076",
"type": "Genes/Proteins",
"text": [
"IFN-beta"
],
"offsets": [
[
1570,
1578
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d20.s7.e1"
}
]
},
{
"id": "1077",
"type": "Non-Specific_miRNAs",
"text": [
"microRNAs"
],
"offsets": [
[
1485,
1494
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d20.s7.e2"
}
]
},
{
"id": "1078",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
[
1496,
1502
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d20.s7.e3"
}
]
},
{
"id": "1079",
"type": "Relation_Trigger",
"text": [
"regulate"
],
"offsets": [
[
1561,
1569
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d20.s7.e4"
}
]
},
{
"id": "1080",
"type": "Specific_miRNAs",
"text": [
"miR-26a, -34a, -145"
],
"offsets": [
[
1515,
1534
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d20.s7.e5"
}
]
},
{
"id": "1081",
"type": "Species",
"text": [
"human"
],
"offsets": [
[
1582,
1587
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d20.s7.e6"
}
]
}
] | [] | [] | [
{
"id": "1082",
"type": "Non-Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d20.s0.e1",
"arg2_id": "miRNA-corp.d20.s0.e0",
"normalized": []
},
{
"id": "1083",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d20.s1.e1",
"arg2_id": "miRNA-corp.d20.s1.e3",
"normalized": []
},
{
"id": "1084",
"type": "Non-Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d20.s1.e1",
"arg2_id": "miRNA-corp.d20.s1.e0",
"normalized": []
},
{
"id": "1085",
"type": "Non-Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d20.s2.e2",
"arg2_id": "miRNA-corp.d20.s2.e0",
"normalized": []
},
{
"id": "1086",
"type": "Non-Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d20.s2.e2",
"arg2_id": "miRNA-corp.d20.s2.e1",
"normalized": []
},
{
"id": "1087",
"type": "Non-Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d20.s2.e2",
"arg2_id": "miRNA-corp.d20.s2.e3",
"normalized": []
},
{
"id": "1088",
"type": "Non-Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d20.s3.e0",
"arg2_id": "miRNA-corp.d20.s3.e1",
"normalized": []
},
{
"id": "1089",
"type": "Non-Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d20.s7.e2",
"arg2_id": "miRNA-corp.d20.s7.e1",
"normalized": []
},
{
"id": "1090",
"type": "Non-Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d20.s7.e3",
"arg2_id": "miRNA-corp.d20.s7.e1",
"normalized": []
},
{
"id": "1091",
"type": "Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d20.s7.e5",
"arg2_id": "miRNA-corp.d20.s7.e1",
"normalized": []
},
{
"id": "1092",
"type": "Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d20.s7.e0",
"arg2_id": "miRNA-corp.d20.s7.e1",
"normalized": []
}
] |
1127 | miRNA-corp.d21 | [
{
"id": "1094",
"type": "title",
"text": [
"Identification of miRNA changes in Alzheimer's disease brain and CSF yields putative biomarkers and insights into disease pathways. "
],
"offsets": [
[
0,
133
]
]
},
{
"id": "1095",
"type": "abstract",
"text": [
"MicroRNAs have essential functional roles in brain development and neuronal specification but their roles in neurodegenerative diseases such as Alzheimer's disease (AD) is unknown. "
],
"offsets": [
[
134,
315
]
]
},
{
"id": "1096",
"type": "abstract",
"text": [
"Using a sensitive qRT-PCR platform we identified regional and stage-specific deregulation of miRNA expression in AD patient brains. "
],
"offsets": [
[
316,
448
]
]
},
{
"id": "1097",
"type": "abstract",
"text": [
"We used experimental validation in addition to literature to reveal how the deregulated brain microRNAs are biomarkers for known and novel pathways in AD pathogenesis related to amyloid processing, neurogenesis, insulin resistance, and innate immunity. "
],
"offsets": [
[
449,
702
]
]
},
{
"id": "1098",
"type": "abstract",
"text": [
"We additionally recovered miRNAs from cerebrospinal fluid and discovered AD-specific miRNA changes consistent with their role as potential biomarkers of disease. "
],
"offsets": [
[
703,
867
]
]
}
] | [
{
"id": "1099",
"type": "Non-Specific_miRNAs",
"text": [
"miRNA"
],
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[
18,
23
]
],
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{
"db_name": "miRNA-corpus",
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]
},
{
"id": "1100",
"type": "Diseases",
"text": [
"Alzheimer's disease"
],
"offsets": [
[
35,
54
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d21.s0.e1"
}
]
},
{
"id": "1101",
"type": "Non-Specific_miRNAs",
"text": [
"MicroRNAs"
],
"offsets": [
[
134,
143
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d21.s1.e0"
}
]
},
{
"id": "1102",
"type": "Diseases",
"text": [
"Alzheimer's disease"
],
"offsets": [
[
278,
297
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d21.s1.e1"
}
]
},
{
"id": "1103",
"type": "Diseases",
"text": [
"AD"
],
"offsets": [
[
299,
301
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d21.s1.e2"
}
]
},
{
"id": "1104",
"type": "Diseases",
"text": [
"neurodegenerative diseases"
],
"offsets": [
[
243,
269
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d21.s1.e3"
}
]
},
{
"id": "1105",
"type": "Non-Specific_miRNAs",
"text": [
"miRNA"
],
"offsets": [
[
409,
414
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d21.s2.e0"
}
]
},
{
"id": "1106",
"type": "Diseases",
"text": [
"AD"
],
"offsets": [
[
429,
431
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d21.s2.e1"
}
]
},
{
"id": "1107",
"type": "Relation_Trigger",
"text": [
"deregulation of miRNA expression"
],
"offsets": [
[
393,
425
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d21.s2.e2"
}
]
},
{
"id": "1108",
"type": "Species",
"text": [
"patient"
],
"offsets": [
[
432,
439
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d21.s2.e3"
}
]
},
{
"id": "1109",
"type": "Non-Specific_miRNAs",
"text": [
"microRNAs"
],
"offsets": [
[
543,
552
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d21.s3.e0"
}
]
},
{
"id": "1110",
"type": "Diseases",
"text": [
"AD"
],
"offsets": [
[
600,
602
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d21.s3.e1"
}
]
},
{
"id": "1111",
"type": "Diseases",
"text": [
"insulin resistance"
],
"offsets": [
[
661,
679
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d21.s3.e2"
}
]
},
{
"id": "1112",
"type": "Genes/Proteins",
"text": [
"insulin"
],
"offsets": [
[
661,
668
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d21.s3.e3"
}
]
},
{
"id": "1113",
"type": "Relation_Trigger",
"text": [
"deregulated"
],
"offsets": [
[
525,
536
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d21.s3.e4"
}
]
},
{
"id": "1114",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
[
729,
735
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d21.s4.e0"
}
]
},
{
"id": "1115",
"type": "Non-Specific_miRNAs",
"text": [
"miRNA"
],
"offsets": [
[
788,
793
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d21.s4.e1"
}
]
},
{
"id": "1116",
"type": "Diseases",
"text": [
"AD"
],
"offsets": [
[
776,
778
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d21.s4.e2"
}
]
}
] | [] | [] | [
{
"id": "1117",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d21.s0.e0",
"arg2_id": "miRNA-corp.d21.s0.e1",
"normalized": []
},
{
"id": "1118",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d21.s1.e0",
"arg2_id": "miRNA-corp.d21.s1.e3",
"normalized": []
},
{
"id": "1119",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d21.s1.e0",
"arg2_id": "miRNA-corp.d21.s1.e1",
"normalized": []
},
{
"id": "1120",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d21.s1.e0",
"arg2_id": "miRNA-corp.d21.s1.e2",
"normalized": []
},
{
"id": "1121",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d21.s2.e0",
"arg2_id": "miRNA-corp.d21.s2.e1",
"normalized": []
},
{
"id": "1122",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d21.s3.e0",
"arg2_id": "miRNA-corp.d21.s3.e1",
"normalized": []
},
{
"id": "1123",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d21.s3.e0",
"arg2_id": "miRNA-corp.d21.s3.e2",
"normalized": []
},
{
"id": "1124",
"type": "Non-Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d21.s3.e0",
"arg2_id": "miRNA-corp.d21.s3.e3",
"normalized": []
},
{
"id": "1125",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d21.s4.e0",
"arg2_id": "miRNA-corp.d21.s4.e2",
"normalized": []
},
{
"id": "1126",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d21.s4.e1",
"arg2_id": "miRNA-corp.d21.s4.e2",
"normalized": []
}
] |
1199 | miRNA-corp.d22 | [
{
"id": "1128",
"type": "title",
"text": [
"In sum, our results suggest that specific miRNAs are involved in the fine-tuning of APP alternative splicing in neurons. "
],
"offsets": [
[
0,
121
]
]
},
{
"id": "1129",
"type": "abstract",
"text": [
"Finally, we show that miR-124 is down-regulated in AD brain. "
],
"offsets": [
[
122,
183
]
]
},
{
"id": "1130",
"type": "abstract",
"text": [
"Furthermore, PTBP1 levels correlate with the presence of APP exons 7 and 8, while PTBP2 levels correlate with the skipping of these exons during neuronal differentiation. "
],
"offsets": [
[
184,
355
]
]
},
{
"id": "1131",
"type": "abstract",
"text": [
"Similar results were obtained by depletion of endogenous polypyrimidine tract binding protein 1 (PTBP1) in cells, a recognized miR-124 target gene. "
],
"offsets": [
[
356,
504
]
]
},
{
"id": "1132",
"type": "abstract",
"text": [
"In vivo regulation of amyloid precursor protein neuronal splicing by microRNAs. "
],
"offsets": [
[
505,
586
]
]
},
{
"id": "1133",
"type": "abstract",
"text": [
"The β-amyloid peptide that accumulate in Alzheimer's disease (AD) brain derive from proteolytic processing of the amyloid precursor protein (APP). "
],
"offsets": [
[
587,
734
]
]
},
{
"id": "1134",
"type": "abstract",
"text": [
"Here, we present evidence that, besides APP expression regulation, miRNAs are equally involved in the regulation of neuronal APP mRNA alternative splicing. "
],
"offsets": [
[
735,
891
]
]
},
{
"id": "1135",
"type": "abstract",
"text": [
"Lack of miRNAs in post-mitotic neurons in vivo is associated with APP exons 7 and 8 inclusion, while ectopic expression of miR-124, an abundant neuronal-specific miRNA, reversed these effects in cultured neurons. "
],
"offsets": [
[
892,
1105
]
]
},
{
"id": "1136",
"type": "abstract",
"text": [
"Recent evidence suggest that microRNAs (miRNAs) participate in the post-transcriptional regulation of APP expression. "
],
"offsets": [
[
1106,
1224
]
]
},
{
"id": "1137",
"type": "abstract",
"text": [
"Because gene dosage effects of the APP gene can cause genetic AD, dysregulation of the miRNA network could contribute significantly to disease. "
],
"offsets": [
[
1225,
1369
]
]
},
{
"id": "1138",
"type": "abstract",
"text": [
"Since abnormal neuronal splicing of APP affects β-amyloid peptide production, these results could contribute to the understanding of the implication of miRNAs in brain health and disease. "
],
"offsets": [
[
1370,
1560
]
]
}
] | [
{
"id": "1139",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
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[
42,
48
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d22.s0.e0"
}
]
},
{
"id": "1140",
"type": "Genes/Proteins",
"text": [
"APP"
],
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84,
87
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d22.s0.e1"
}
]
},
{
"id": "1141",
"type": "Relation_Trigger",
"text": [
"down-regulated"
],
"offsets": [
[
155,
169
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d22.s1.e0"
}
]
},
{
"id": "1142",
"type": "Specific_miRNAs",
"text": [
"miR-124"
],
"offsets": [
[
144,
151
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d22.s1.e1"
}
]
},
{
"id": "1143",
"type": "Diseases",
"text": [
"AD"
],
"offsets": [
[
173,
175
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d22.s1.e2"
}
]
},
{
"id": "1144",
"type": "Relation_Trigger",
"text": [
"levels correlate"
],
"offsets": [
[
203,
219
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d22.s2.e0"
}
]
},
{
"id": "1145",
"type": "Relation_Trigger",
"text": [
"levels correlate"
],
"offsets": [
[
272,
288
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d22.s2.e1"
}
]
},
{
"id": "1146",
"type": "Genes/Proteins",
"text": [
"APP"
],
"offsets": [
[
241,
244
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d22.s2.e2"
}
]
},
{
"id": "1147",
"type": "Genes/Proteins",
"text": [
"PTBP2"
],
"offsets": [
[
266,
271
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d22.s2.e3"
}
]
},
{
"id": "1148",
"type": "Genes/Proteins",
"text": [
"PTBP1"
],
"offsets": [
[
197,
202
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d22.s2.e4"
}
]
},
{
"id": "1149",
"type": "Genes/Proteins",
"text": [
"polypyrimidine tract binding protein"
],
"offsets": [
[
413,
449
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d22.s3.e0"
}
]
},
{
"id": "1150",
"type": "Genes/Proteins",
"text": [
"PTBP1"
],
"offsets": [
[
453,
458
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d22.s3.e1"
}
]
},
{
"id": "1151",
"type": "Specific_miRNAs",
"text": [
"miR-124"
],
"offsets": [
[
483,
490
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d22.s3.e2"
}
]
},
{
"id": "1152",
"type": "Relation_Trigger",
"text": [
"target"
],
"offsets": [
[
491,
497
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d22.s3.e3"
}
]
},
{
"id": "1153",
"type": "Non-Specific_miRNAs",
"text": [
"microRNAs"
],
"offsets": [
[
574,
583
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d22.s4.e0"
}
]
},
{
"id": "1154",
"type": "Genes/Proteins",
"text": [
"amyloid precursor protein"
],
"offsets": [
[
527,
552
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d22.s4.e1"
}
]
},
{
"id": "1155",
"type": "Relation_Trigger",
"text": [
"regulation"
],
"offsets": [
[
513,
523
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d22.s4.e2"
}
]
},
{
"id": "1156",
"type": "Diseases",
"text": [
"Alzheimer's disease"
],
"offsets": [
[
628,
647
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d22.s5.e0"
}
]
},
{
"id": "1157",
"type": "Diseases",
"text": [
"AD"
],
"offsets": [
[
649,
651
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d22.s5.e1"
}
]
},
{
"id": "1158",
"type": "Genes/Proteins",
"text": [
"amyloid precursor protein"
],
"offsets": [
[
701,
726
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d22.s5.e2"
}
]
},
{
"id": "1159",
"type": "Genes/Proteins",
"text": [
"APP"
],
"offsets": [
[
728,
731
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d22.s5.e3"
}
]
},
{
"id": "1160",
"type": "Genes/Proteins",
"text": [
"β-amyloid peptide"
],
"offsets": [
[
591,
608
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d22.s5.e4"
}
]
},
{
"id": "1161",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
[
802,
808
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d22.s6.e0"
}
]
},
{
"id": "1162",
"type": "Relation_Trigger",
"text": [
"expression regulation"
],
"offsets": [
[
779,
800
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d22.s6.e1"
}
]
},
{
"id": "1163",
"type": "Relation_Trigger",
"text": [
"regulation"
],
"offsets": [
[
837,
847
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d22.s6.e2"
}
]
},
{
"id": "1164",
"type": "Genes/Proteins",
"text": [
"APP"
],
"offsets": [
[
775,
778
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d22.s6.e3"
}
]
},
{
"id": "1165",
"type": "Genes/Proteins",
"text": [
"APP"
],
"offsets": [
[
860,
863
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d22.s6.e4"
}
]
},
{
"id": "1166",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
[
900,
906
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d22.s7.e0"
}
]
},
{
"id": "1167",
"type": "Non-Specific_miRNAs",
"text": [
"miRNA"
],
"offsets": [
[
1054,
1059
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d22.s7.e1"
}
]
},
{
"id": "1168",
"type": "Relation_Trigger",
"text": [
"ectopic expression"
],
"offsets": [
[
993,
1011
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d22.s7.e2"
}
]
},
{
"id": "1169",
"type": "Genes/Proteins",
"text": [
"APP"
],
"offsets": [
[
958,
961
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d22.s7.e3"
}
]
},
{
"id": "1170",
"type": "Specific_miRNAs",
"text": [
"miR-124"
],
"offsets": [
[
1015,
1022
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d22.s7.e4"
}
]
},
{
"id": "1171",
"type": "Relation_Trigger",
"text": [
"associated"
],
"offsets": [
[
942,
952
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d22.s7.e5"
}
]
},
{
"id": "1172",
"type": "Non-Specific_miRNAs",
"text": [
"microRNAs"
],
"offsets": [
[
1135,
1144
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d22.s8.e0"
}
]
},
{
"id": "1173",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
[
1146,
1152
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d22.s8.e1"
}
]
},
{
"id": "1174",
"type": "Relation_Trigger",
"text": [
"regulation of APP expression"
],
"offsets": [
[
1194,
1222
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d22.s8.e2"
}
]
},
{
"id": "1175",
"type": "Genes/Proteins",
"text": [
"APP"
],
"offsets": [
[
1208,
1211
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d22.s8.e3"
}
]
},
{
"id": "1176",
"type": "Relation_Trigger",
"text": [
"dysregulation"
],
"offsets": [
[
1291,
1304
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d22.s9.e0"
}
]
},
{
"id": "1177",
"type": "Genes/Proteins",
"text": [
"APP"
],
"offsets": [
[
1260,
1263
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d22.s9.e1"
}
]
},
{
"id": "1178",
"type": "Diseases",
"text": [
"AD"
],
"offsets": [
[
1287,
1289
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d22.s9.e2"
}
]
},
{
"id": "1179",
"type": "Non-Specific_miRNAs",
"text": [
"miRNA"
],
"offsets": [
[
1312,
1317
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d22.s9.e3"
}
]
},
{
"id": "1180",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
[
1522,
1528
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d22.s10.e0"
}
]
},
{
"id": "1181",
"type": "Genes/Proteins",
"text": [
"APP"
],
"offsets": [
[
1406,
1409
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d22.s10.e1"
}
]
},
{
"id": "1182",
"type": "Genes/Proteins",
"text": [
"amyloid peptide"
],
"offsets": [
[
1420,
1435
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d22.s10.e2"
}
]
}
] | [] | [] | [
{
"id": "1183",
"type": "Non-Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d22.s0.e0",
"arg2_id": "miRNA-corp.d22.s0.e1",
"normalized": []
},
{
"id": "1184",
"type": "Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d22.s1.e1",
"arg2_id": "miRNA-corp.d22.s1.e2",
"normalized": []
},
{
"id": "1185",
"type": "Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d22.s3.e2",
"arg2_id": "miRNA-corp.d22.s3.e0",
"normalized": []
},
{
"id": "1186",
"type": "Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d22.s3.e2",
"arg2_id": "miRNA-corp.d22.s3.e1",
"normalized": []
},
{
"id": "1187",
"type": "Non-Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d22.s4.e0",
"arg2_id": "miRNA-corp.d22.s4.e1",
"normalized": []
},
{
"id": "1188",
"type": "Non-Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d22.s6.e0",
"arg2_id": "miRNA-corp.d22.s6.e3",
"normalized": []
},
{
"id": "1189",
"type": "Non-Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d22.s6.e0",
"arg2_id": "miRNA-corp.d22.s6.e4",
"normalized": []
},
{
"id": "1190",
"type": "Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d22.s7.e4",
"arg2_id": "miRNA-corp.d22.s7.e3",
"normalized": []
},
{
"id": "1191",
"type": "Non-Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d22.s7.e0",
"arg2_id": "miRNA-corp.d22.s7.e3",
"normalized": []
},
{
"id": "1192",
"type": "Non-Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d22.s7.e1",
"arg2_id": "miRNA-corp.d22.s7.e3",
"normalized": []
},
{
"id": "1193",
"type": "Non-Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d22.s8.e0",
"arg2_id": "miRNA-corp.d22.s8.e3",
"normalized": []
},
{
"id": "1194",
"type": "Non-Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d22.s8.e1",
"arg2_id": "miRNA-corp.d22.s8.e3",
"normalized": []
},
{
"id": "1195",
"type": "Non-Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d22.s9.e3",
"arg2_id": "miRNA-corp.d22.s9.e1",
"normalized": []
},
{
"id": "1196",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d22.s9.e3",
"arg2_id": "miRNA-corp.d22.s9.e2",
"normalized": []
},
{
"id": "1197",
"type": "Non-Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d22.s10.e0",
"arg2_id": "miRNA-corp.d22.s10.e1",
"normalized": []
},
{
"id": "1198",
"type": "Non-Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d22.s10.e0",
"arg2_id": "miRNA-corp.d22.s10.e2",
"normalized": []
}
] |
1262 | miRNA-corp.d23 | [
{
"id": "1200",
"type": "title",
"text": [
"A greater understanding of aberrant miRNA expression in pediatric brain tumors may aid in the development of novel therapies. "
],
"offsets": [
[
0,
126
]
]
},
{
"id": "1201",
"type": "abstract",
"text": [
"The characterization of tumor-specific miRNA signatures may aid in the discovery of biomarkers with diagnostic or prognostic utility. "
],
"offsets": [
[
127,
263
]
]
},
{
"id": "1202",
"type": "abstract",
"text": [
"The present study provides an initial survey of miRNA expression in pediatric central nervous system (CNS) malignancies including atypical teratoid/rhabdoid tumor, ependymoma, glioblastoma, medulloblastoma, and pilocytic astrocytoma. "
],
"offsets": [
[
264,
498
]
]
},
{
"id": "1203",
"type": "abstract",
"text": [
"PROCEDURE: MicroRNA expression in pediatric brain tumors and normal tissue controls was examined by microarray. "
],
"offsets": [
[
499,
611
]
]
},
{
"id": "1204",
"type": "abstract",
"text": [
"BACKGROUND: A better understanding of pediatric brain tumor biology is needed to assist in the development of less toxic therapies and to provide better markers for disease stratification. "
],
"offsets": [
[
612,
801
]
]
},
{
"id": "1205",
"type": "abstract",
"text": [
"MicroRNAs (miRNA) may play a significant role in brain tumor biology. "
],
"offsets": [
[
802,
872
]
]
},
{
"id": "1206",
"type": "abstract",
"text": [
"When further examined by qRT-PCR, these miRNAs demonstrated differential expression that significantly correlated with the microarray findings. "
],
"offsets": [
[
873,
1017
]
]
},
{
"id": "1207",
"type": "abstract",
"text": [
"Distinctive miRNA expression profiles were also observed in the different pediatric brain tumor types. "
],
"offsets": [
[
1018,
1121
]
]
},
{
"id": "1208",
"type": "abstract",
"text": [
"Three aberrantly expressed miRNAs were further studied in a larger cohort by quantitative real-time PCR (qRT-PCR). "
],
"offsets": [
[
1122,
1237
]
]
},
{
"id": "1209",
"type": "abstract",
"text": [
"RESULTS: MicroRNA-129, miR-142-5p, and miR-25 were differentially expressed in every pediatric brain tumor type compared to normal tissue controls as measured by microarray. "
],
"offsets": [
[
1238,
1412
]
]
},
{
"id": "1210",
"type": "abstract",
"text": [
"CONCLUSIONS: MicroRNAs are differentially expressed between pediatric CNS neoplasms and normal tissue suggesting that they may play a significant role in oncogenesis. "
],
"offsets": [
[
1413,
1580
]
]
},
{
"id": "1211",
"type": "abstract",
"text": [
"Survey of MicroRNA expression in pediatric brain tumors. "
],
"offsets": [
[
1581,
1639
]
]
}
] | [
{
"id": "1212",
"type": "Non-Specific_miRNAs",
"text": [
"miRNA"
],
"offsets": [
[
36,
41
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d23.s0.e0"
}
]
},
{
"id": "1213",
"type": "Diseases",
"text": [
"brain tumors"
],
"offsets": [
[
66,
78
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d23.s0.e1"
}
]
},
{
"id": "1214",
"type": "Relation_Trigger",
"text": [
"aberrant miRNA expression"
],
"offsets": [
[
27,
52
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d23.s0.e2"
}
]
},
{
"id": "1215",
"type": "Non-Specific_miRNAs",
"text": [
"miRNA"
],
"offsets": [
[
166,
171
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d23.s1.e0"
}
]
},
{
"id": "1216",
"type": "Diseases",
"text": [
"tumor"
],
"offsets": [
[
151,
156
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d23.s1.e1"
}
]
},
{
"id": "1217",
"type": "Non-Specific_miRNAs",
"text": [
"miRNA"
],
"offsets": [
[
312,
317
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d23.s2.e0"
}
]
},
{
"id": "1218",
"type": "Diseases",
"text": [
"ependymoma"
],
"offsets": [
[
428,
438
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d23.s2.e1"
}
]
},
{
"id": "1219",
"type": "Diseases",
"text": [
"glioblastoma"
],
"offsets": [
[
440,
452
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d23.s2.e2"
}
]
},
{
"id": "1220",
"type": "Diseases",
"text": [
"medulloblastoma"
],
"offsets": [
[
454,
469
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d23.s2.e3"
}
]
},
{
"id": "1221",
"type": "Diseases",
"text": [
"pilocytic astrocytoma"
],
"offsets": [
[
475,
496
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d23.s2.e4"
}
]
},
{
"id": "1222",
"type": "Diseases",
"text": [
"rhabdoid tumor"
],
"offsets": [
[
412,
426
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d23.s2.e5"
}
]
},
{
"id": "1223",
"type": "Non-Specific_miRNAs",
"text": [
"MicroRNA"
],
"offsets": [
[
510,
518
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d23.s3.e0"
}
]
},
{
"id": "1224",
"type": "Diseases",
"text": [
"brain tumors"
],
"offsets": [
[
543,
555
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d23.s3.e1"
}
]
},
{
"id": "1225",
"type": "Diseases",
"text": [
"brain tumor"
],
"offsets": [
[
660,
671
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d23.s4.e0"
}
]
},
{
"id": "1226",
"type": "Non-Specific_miRNAs",
"text": [
"MicroRNAs"
],
"offsets": [
[
802,
811
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d23.s5.e0"
}
]
},
{
"id": "1227",
"type": "Non-Specific_miRNAs",
"text": [
"miRNA"
],
"offsets": [
[
813,
818
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d23.s5.e1"
}
]
},
{
"id": "1228",
"type": "Diseases",
"text": [
"brain tumor"
],
"offsets": [
[
851,
862
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d23.s5.e2"
}
]
},
{
"id": "1229",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
[
913,
919
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d23.s6.e0"
}
]
},
{
"id": "1230",
"type": "Relation_Trigger",
"text": [
"differential expression"
],
"offsets": [
[
933,
956
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d23.s6.e1"
}
]
},
{
"id": "1231",
"type": "Relation_Trigger",
"text": [
"expression that significantly correlated"
],
"offsets": [
[
946,
986
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d23.s6.e2"
}
]
},
{
"id": "1232",
"type": "Non-Specific_miRNAs",
"text": [
"miRNA"
],
"offsets": [
[
1030,
1035
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d23.s7.e0"
}
]
},
{
"id": "1233",
"type": "Diseases",
"text": [
"brain tumor"
],
"offsets": [
[
1102,
1113
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d23.s7.e1"
}
]
},
{
"id": "1234",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
[
1149,
1155
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d23.s8.e0"
}
]
},
{
"id": "1235",
"type": "Relation_Trigger",
"text": [
"aberrantly expressed"
],
"offsets": [
[
1128,
1148
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d23.s8.e1"
}
]
},
{
"id": "1236",
"type": "Diseases",
"text": [
"brain tumor"
],
"offsets": [
[
1333,
1344
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d23.s9.e0"
}
]
},
{
"id": "1237",
"type": "Relation_Trigger",
"text": [
"differentially expressed"
],
"offsets": [
[
1289,
1313
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d23.s9.e1"
}
]
},
{
"id": "1238",
"type": "Specific_miRNAs",
"text": [
"MicroRNA-129"
],
"offsets": [
[
1247,
1259
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d23.s9.e2"
}
]
},
{
"id": "1239",
"type": "Specific_miRNAs",
"text": [
"miR-142-5p"
],
"offsets": [
[
1261,
1271
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d23.s9.e3"
}
]
},
{
"id": "1240",
"type": "Specific_miRNAs",
"text": [
"miR-25"
],
"offsets": [
[
1277,
1283
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d23.s9.e4"
}
]
},
{
"id": "1241",
"type": "Non-Specific_miRNAs",
"text": [
"MicroRNAs"
],
"offsets": [
[
1426,
1435
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d23.s10.e0"
}
]
},
{
"id": "1242",
"type": "Relation_Trigger",
"text": [
"differentially expressed"
],
"offsets": [
[
1440,
1464
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d23.s10.e1"
}
]
},
{
"id": "1243",
"type": "Diseases",
"text": [
"neoplasms"
],
"offsets": [
[
1487,
1496
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d23.s10.e2"
}
]
},
{
"id": "1244",
"type": "Non-Specific_miRNAs",
"text": [
"MicroRNA"
],
"offsets": [
[
1591,
1599
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d23.s11.e0"
}
]
},
{
"id": "1245",
"type": "Diseases",
"text": [
"brain tumors"
],
"offsets": [
[
1624,
1636
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d23.s11.e1"
}
]
}
] | [] | [] | [
{
"id": "1246",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d23.s0.e0",
"arg2_id": "miRNA-corp.d23.s0.e1",
"normalized": []
},
{
"id": "1247",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d23.s1.e0",
"arg2_id": "miRNA-corp.d23.s1.e1",
"normalized": []
},
{
"id": "1248",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d23.s2.e0",
"arg2_id": "miRNA-corp.d23.s2.e1",
"normalized": []
},
{
"id": "1249",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d23.s2.e0",
"arg2_id": "miRNA-corp.d23.s2.e2",
"normalized": []
},
{
"id": "1250",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d23.s2.e0",
"arg2_id": "miRNA-corp.d23.s2.e3",
"normalized": []
},
{
"id": "1251",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d23.s2.e0",
"arg2_id": "miRNA-corp.d23.s2.e4",
"normalized": []
},
{
"id": "1252",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d23.s2.e0",
"arg2_id": "miRNA-corp.d23.s2.e5",
"normalized": []
},
{
"id": "1253",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d23.s3.e0",
"arg2_id": "miRNA-corp.d23.s3.e1",
"normalized": []
},
{
"id": "1254",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d23.s5.e0",
"arg2_id": "miRNA-corp.d23.s5.e2",
"normalized": []
},
{
"id": "1255",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d23.s5.e1",
"arg2_id": "miRNA-corp.d23.s5.e2",
"normalized": []
},
{
"id": "1256",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d23.s7.e0",
"arg2_id": "miRNA-corp.d23.s7.e1",
"normalized": []
},
{
"id": "1257",
"type": "Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d23.s9.e2",
"arg2_id": "miRNA-corp.d23.s9.e0",
"normalized": []
},
{
"id": "1258",
"type": "Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d23.s9.e3",
"arg2_id": "miRNA-corp.d23.s9.e0",
"normalized": []
},
{
"id": "1259",
"type": "Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d23.s9.e4",
"arg2_id": "miRNA-corp.d23.s9.e0",
"normalized": []
},
{
"id": "1260",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d23.s10.e0",
"arg2_id": "miRNA-corp.d23.s10.e2",
"normalized": []
},
{
"id": "1261",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d23.s11.e0",
"arg2_id": "miRNA-corp.d23.s11.e1",
"normalized": []
}
] |
1277 | miRNA-corp.d24 | [
{
"id": "1263",
"type": "title",
"text": [
"The authors reviewed the records of nineteen consecutive children with newly diagnosed IIH in order to compare demographic characteristics, clinical pictures and ophthalmologic aspects as optic disc evaluation and visual field evaluation, as well as treatment modalities and follow up. "
],
"offsets": [
[
0,
286
]
]
},
{
"id": "1264",
"type": "abstract",
"text": [
"Beside obesity and female gender, potential alternative risk factors remains to be investigated, which need a good collaboration between neuro-ophthalmologists and pediatric neurologists. "
],
"offsets": [
[
287,
477
]
]
},
{
"id": "1265",
"type": "abstract",
"text": [
"Idiopathic intracranial hypertension (IIH) is a clinical condition characterized by elevated intracranial pressure and absence of clinical, laboratory or radiographic evidence of central nervous system infection, vascular malformation, intracranial space occupying lesion or hydrocephalus. "
],
"offsets": [
[
478,
768
]
]
},
{
"id": "1266",
"type": "abstract",
"text": [
"Pediatric idiopathic intracranial hypertension: clinical and demographic features. "
],
"offsets": [
[
769,
853
]
]
}
] | [
{
"id": "1267",
"type": "Species",
"text": [
"children"
],
"offsets": [
[
57,
65
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d24.s0.e0"
}
]
},
{
"id": "1268",
"type": "Diseases",
"text": [
"obesity"
],
"offsets": [
[
294,
301
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d24.s1.e0"
}
]
},
{
"id": "1269",
"type": "Diseases",
"text": [
"elevated intracranial pressure"
],
"offsets": [
[
562,
592
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d24.s2.e0"
}
]
},
{
"id": "1270",
"type": "Diseases",
"text": [
"Idiopathic intracranial hypertension"
],
"offsets": [
[
478,
514
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d24.s2.e1"
}
]
},
{
"id": "1271",
"type": "Diseases",
"text": [
"IIH"
],
"offsets": [
[
516,
519
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d24.s2.e2"
}
]
},
{
"id": "1272",
"type": "Diseases",
"text": [
"hydrocephalus"
],
"offsets": [
[
753,
766
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d24.s2.e3"
}
]
},
{
"id": "1273",
"type": "Diseases",
"text": [
"lesion"
],
"offsets": [
[
743,
749
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d24.s2.e4"
}
]
},
{
"id": "1274",
"type": "Diseases",
"text": [
"vascular malformation"
],
"offsets": [
[
691,
712
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d24.s2.e5"
}
]
},
{
"id": "1275",
"type": "Diseases",
"text": [
"central nervous system infection"
],
"offsets": [
[
657,
689
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d24.s2.e6"
}
]
},
{
"id": "1276",
"type": "Diseases",
"text": [
"idiopathic intracranial hypertension"
],
"offsets": [
[
779,
815
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d24.s4.e0"
}
]
}
] | [] | [] | [] |
1326 | miRNA-corp.d25 | [
{
"id": "1278",
"type": "title",
"text": [
"In this review, we summarise the current knowledge of miR-21 functions in human disease, with an emphasis on its regulation, oncogenic role, targets in human cancers, potential as a disease biomarker and novel therapeutic target in oncology. "
],
"offsets": [
[
0,
244
]
]
},
{
"id": "1279",
"type": "abstract",
"text": [
"However, an miR-21 knockout mouse has not yet been generated, and the data about miR-21 functions in normal cells are still very limited. "
],
"offsets": [
[
245,
383
]
]
},
{
"id": "1280",
"type": "abstract",
"text": [
"Since its identification 3 years ago as the miRNA most commonly and strongly up-regulated in human brain tumour glioblastoma [1], miR-21 has attracted the attention of researchers in various fields, such as development, oncology, stem cell biology and aging, becoming one of the most studied miRNAs, along with let-7, miR-17-92 cluster ('oncomir-1'), miR-155 and a few others. "
],
"offsets": [
[
384,
761
]
]
},
{
"id": "1281",
"type": "abstract",
"text": [
"Particular miRNAs emerge as principal regulators that control major cell functions in various physiological and pathophysiological settings. "
],
"offsets": [
[
762,
903
]
]
},
{
"id": "1282",
"type": "abstract",
"text": [
"miR-21: a small multi-faceted RNA. "
],
"offsets": [
[
904,
940
]
]
},
{
"id": "1283",
"type": "abstract",
"text": [
"More than 1000 microRNAs (miRNAs) are expressed in human cells, some tissue or cell type specific, others considered as house-keeping molecules. "
],
"offsets": [
[
941,
1086
]
]
},
{
"id": "1284",
"type": "abstract",
"text": [
"Functions and direct mRNA targets for some miRNAs have been relatively well studied over the last years. "
],
"offsets": [
[
1087,
1192
]
]
},
{
"id": "1285",
"type": "abstract",
"text": [
"Every miRNA potentially regulates the expression of numerous protein-coding genes (tens to hundreds), but it has become increasingly clear that not all miRNAs are equally important; diverse high-throughput screenings of various systems have identified a limited number of key functional miRNAs over and over again. "
],
"offsets": [
[
1193,
1508
]
]
}
] | [
{
"id": "1286",
"type": "Specific_miRNAs",
"text": [
"miR-21"
],
"offsets": [
[
54,
60
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d25.s0.e0"
}
]
},
{
"id": "1287",
"type": "Relation_Trigger",
"text": [
"targets"
],
"offsets": [
[
141,
148
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d25.s0.e1"
}
]
},
{
"id": "1288",
"type": "Relation_Trigger",
"text": [
"therapeutic target"
],
"offsets": [
[
210,
228
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d25.s0.e2"
}
]
},
{
"id": "1289",
"type": "Relation_Trigger",
"text": [
"regulation"
],
"offsets": [
[
113,
123
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d25.s0.e3"
}
]
},
{
"id": "1290",
"type": "Diseases",
"text": [
"cancers"
],
"offsets": [
[
158,
165
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d25.s0.e4"
}
]
},
{
"id": "1291",
"type": "Species",
"text": [
"human"
],
"offsets": [
[
74,
79
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d25.s0.e5"
}
]
},
{
"id": "1292",
"type": "Species",
"text": [
"human"
],
"offsets": [
[
152,
157
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d25.s0.e6"
}
]
},
{
"id": "1293",
"type": "Specific_miRNAs",
"text": [
"miR-21"
],
"offsets": [
[
257,
263
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d25.s1.e0"
}
]
},
{
"id": "1294",
"type": "Specific_miRNAs",
"text": [
"miR-21"
],
"offsets": [
[
326,
332
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d25.s1.e1"
}
]
},
{
"id": "1295",
"type": "Species",
"text": [
"mouse"
],
"offsets": [
[
273,
278
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d25.s1.e2"
}
]
},
{
"id": "1296",
"type": "Specific_miRNAs",
"text": [
"miR-21"
],
"offsets": [
[
514,
520
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d25.s2.e0"
}
]
},
{
"id": "1297",
"type": "Specific_miRNAs",
"text": [
"miR-17-92"
],
"offsets": [
[
702,
711
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d25.s2.e1"
}
]
},
{
"id": "1298",
"type": "Specific_miRNAs",
"text": [
"let-7"
],
"offsets": [
[
695,
700
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d25.s2.e2"
}
]
},
{
"id": "1299",
"type": "Specific_miRNAs",
"text": [
"miR-155"
],
"offsets": [
[
735,
742
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d25.s2.e3"
}
]
},
{
"id": "1300",
"type": "Specific_miRNAs",
"text": [
"oncomir-1"
],
"offsets": [
[
722,
731
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d25.s2.e4"
}
]
},
{
"id": "1301",
"type": "Non-Specific_miRNAs",
"text": [
"miRNA"
],
"offsets": [
[
428,
433
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d25.s2.e5"
}
]
},
{
"id": "1302",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
[
676,
682
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d25.s2.e6"
}
]
},
{
"id": "1303",
"type": "Diseases",
"text": [
"brain tumour glioblastoma"
],
"offsets": [
[
483,
508
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d25.s2.e7"
}
]
},
{
"id": "1304",
"type": "Relation_Trigger",
"text": [
"up-regulated"
],
"offsets": [
[
461,
473
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d25.s2.e8"
}
]
},
{
"id": "1305",
"type": "Species",
"text": [
"human"
],
"offsets": [
[
477,
482
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d25.s2.e9"
}
]
},
{
"id": "1306",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
[
773,
779
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d25.s3.e0"
}
]
},
{
"id": "1307",
"type": "Relation_Trigger",
"text": [
"regulators"
],
"offsets": [
[
800,
810
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d25.s3.e1"
}
]
},
{
"id": "1308",
"type": "Specific_miRNAs",
"text": [
"miR-21"
],
"offsets": [
[
904,
910
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d25.s4.e0"
}
]
},
{
"id": "1309",
"type": "Non-Specific_miRNAs",
"text": [
"microRNAs"
],
"offsets": [
[
956,
965
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d25.s5.e0"
}
]
},
{
"id": "1310",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
[
967,
973
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d25.s5.e1"
}
]
},
{
"id": "1311",
"type": "Species",
"text": [
"human"
],
"offsets": [
[
992,
997
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d25.s5.e2"
}
]
},
{
"id": "1312",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
[
1130,
1136
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d25.s6.e0"
}
]
},
{
"id": "1313",
"type": "Relation_Trigger",
"text": [
"targets"
],
"offsets": [
[
1113,
1120
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d25.s6.e1"
}
]
},
{
"id": "1314",
"type": "Non-Specific_miRNAs",
"text": [
"miRNA"
],
"offsets": [
[
1199,
1204
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d25.s7.e0"
}
]
},
{
"id": "1315",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
[
1345,
1351
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d25.s7.e1"
}
]
},
{
"id": "1316",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
[
1480,
1486
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d25.s7.e2"
}
]
},
{
"id": "1317",
"type": "Relation_Trigger",
"text": [
"regulates the expression"
],
"offsets": [
[
1217,
1241
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d25.s7.e3"
}
]
}
] | [] | [] | [
{
"id": "1318",
"type": "Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d25.s0.e0",
"arg2_id": "miRNA-corp.d25.s0.e4",
"normalized": []
},
{
"id": "1319",
"type": "Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d25.s2.e0",
"arg2_id": "miRNA-corp.d25.s2.e7",
"normalized": []
},
{
"id": "1320",
"type": "Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d25.s2.e4",
"arg2_id": "miRNA-corp.d25.s2.e7",
"normalized": []
},
{
"id": "1321",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d25.s2.e5",
"arg2_id": "miRNA-corp.d25.s2.e7",
"normalized": []
},
{
"id": "1322",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d25.s2.e6",
"arg2_id": "miRNA-corp.d25.s2.e7",
"normalized": []
},
{
"id": "1323",
"type": "Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d25.s2.e1",
"arg2_id": "miRNA-corp.d25.s2.e7",
"normalized": []
},
{
"id": "1324",
"type": "Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d25.s2.e2",
"arg2_id": "miRNA-corp.d25.s2.e7",
"normalized": []
},
{
"id": "1325",
"type": "Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d25.s2.e3",
"arg2_id": "miRNA-corp.d25.s2.e7",
"normalized": []
}
] |
1422 | miRNA-corp.d26 | [
{
"id": "1327",
"type": "title",
"text": [
"Expression levels of select protein-coding genes and miRNAs could classify an independent set of medulloblastomas. "
],
"offsets": [
[
0,
115
]
]
},
{
"id": "1328",
"type": "abstract",
"text": [
"Twelve of 31 medulloblastomas were found to overexpress genes belonging to the canonical WNT signaling pathway and carry a mutation in CTNNB1 gene. "
],
"offsets": [
[
116,
264
]
]
},
{
"id": "1329",
"type": "abstract",
"text": [
"In order to get a better understanding of medulloblastoma biology, miRNA profiling of medulloblastomas was carried out in parallel with expression profiling of protein-coding genes. "
],
"offsets": [
[
265,
447
]
]
},
{
"id": "1330",
"type": "abstract",
"text": [
"MATERIALS AND METHODS: miRNA profiling of medulloblastomas was carried out using Taqman Low Density Array v 1.0 having 365 human microRNAs. "
],
"offsets": [
[
448,
588
]
]
},
{
"id": "1331",
"type": "abstract",
"text": [
"RESULTS: Both the profiling studies identified four molecular subtypes of medulloblastomas. "
],
"offsets": [
[
589,
681
]
]
},
{
"id": "1332",
"type": "abstract",
"text": [
"Distinctive microRNA signature of medulloblastomas associated with the WNT signaling pathway. "
],
"offsets": [
[
682,
777
]
]
},
{
"id": "1333",
"type": "abstract",
"text": [
"AIM: Medulloblastoma is a malignant brain tumor that occurs predominantly in children. "
],
"offsets": [
[
778,
865
]
]
},
{
"id": "1334",
"type": "abstract",
"text": [
"MicroRNA expression is known to be deregulated in various cancers and has been found to be useful in predicting tumor behavior. "
],
"offsets": [
[
866,
994
]
]
},
{
"id": "1335",
"type": "abstract",
"text": [
"A number of miRNAs like miR-193a, miR-224/miR-452 cluster, miR-182/miR-183/miR-96 cluster, and miR-148a having potential tumor/metastasis suppressive activity were found to be overexpressed in the WNT signaling associated medulloblastomas. "
],
"offsets": [
[
995,
1235
]
]
},
{
"id": "1336",
"type": "abstract",
"text": [
"CONCLUSION: Expression level of tumor/metastasis suppressive miRNAs in the WNT signaling associated medulloblastomas is likely to determine their response to treatment, and thus, these miRNAs would be important biomarkers for risk stratification within the WNT signaling associated medulloblastomas. "
],
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"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d26.s11.e2",
"arg2_id": "miRNA-corp.d26.s11.e7",
"normalized": []
},
{
"id": "1414",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d26.s11.e2",
"arg2_id": "miRNA-corp.d26.s11.e0",
"normalized": []
},
{
"id": "1415",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d26.s11.e2",
"arg2_id": "miRNA-corp.d26.s11.e1",
"normalized": []
},
{
"id": "1416",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d26.s11.e3",
"arg2_id": "miRNA-corp.d26.s11.e7",
"normalized": []
},
{
"id": "1417",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d26.s11.e3",
"arg2_id": "miRNA-corp.d26.s11.e0",
"normalized": []
},
{
"id": "1418",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d26.s11.e3",
"arg2_id": "miRNA-corp.d26.s11.e1",
"normalized": []
},
{
"id": "1419",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d26.s12.e0",
"arg2_id": "miRNA-corp.d26.s12.e4",
"normalized": []
},
{
"id": "1420",
"type": "Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d26.s12.e2",
"arg2_id": "miRNA-corp.d26.s12.e4",
"normalized": []
},
{
"id": "1421",
"type": "Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d26.s12.e3",
"arg2_id": "miRNA-corp.d26.s12.e4",
"normalized": []
}
] |
1442 | miRNA-corp.d27 | [
{
"id": "1423",
"type": "title",
"text": [
"We now report clinical and genetic findings in nine additional European families with myoclonus-dystonia syndrome. "
],
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0,
115
]
]
},
{
"id": "1424",
"type": "abstract",
"text": [
"Mutations in the gene for epsilon-sarcoglycan (SGCE) have been found to cause myoclonus-dystonia syndrome. "
],
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116,
223
]
]
},
{
"id": "1425",
"type": "abstract",
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"Six novel and one previously known heterozygous SGCE mutations were identified. "
],
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[
224,
304
]
]
},
{
"id": "1426",
"type": "abstract",
"text": [
"The clinical presentation in 24 affecteds was homogeneous with myoclonus predominantly of neck and upper limbs in 23 of them and dystonia, presenting as cervical dystonia and/or writer's cramp, in 13 cases. "
],
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[
305,
512
]
]
},
{
"id": "1427",
"type": "abstract",
"text": [
"SGCE deficiency seems to be the common pathogenetic mechanism in myoclonus-dystonia syndrome. "
],
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513,
609
]
]
},
{
"id": "1428",
"type": "abstract",
"text": [
"Myoclonus-dystonia syndrome: epsilon-sarcoglycan mutations and phenotype. "
],
"offsets": [
[
610,
685
]
]
}
] | [
{
"id": "1429",
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86,
113
]
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"db_name": "miRNA-corpus",
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}
]
},
{
"id": "1430",
"type": "Genes/Proteins",
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"epsilon-sarcoglycan"
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142,
161
]
],
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"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d27.s1.e0"
}
]
},
{
"id": "1431",
"type": "Genes/Proteins",
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"SGCE"
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[
163,
167
]
],
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{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d27.s1.e1"
}
]
},
{
"id": "1432",
"type": "Diseases",
"text": [
"myoclonus-dystonia syndrome"
],
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[
194,
221
]
],
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{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d27.s1.e2"
}
]
},
{
"id": "1433",
"type": "Genes/Proteins",
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"SGCE"
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[
272,
276
]
],
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{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d27.s2.e0"
}
]
},
{
"id": "1434",
"type": "Diseases",
"text": [
"dystonia"
],
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[
434,
442
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d27.s3.e0"
}
]
},
{
"id": "1435",
"type": "Diseases",
"text": [
"myoclonus"
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[
368,
377
]
],
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{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d27.s3.e1"
}
]
},
{
"id": "1436",
"type": "Diseases",
"text": [
"cervical dystonia"
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[
458,
475
]
],
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{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d27.s3.e2"
}
]
},
{
"id": "1437",
"type": "Diseases",
"text": [
"writer's cramp"
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[
483,
497
]
],
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{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d27.s3.e3"
}
]
},
{
"id": "1438",
"type": "Genes/Proteins",
"text": [
"SGCE"
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[
513,
517
]
],
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{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d27.s4.e0"
}
]
},
{
"id": "1439",
"type": "Diseases",
"text": [
"myoclonus-dystonia syndrome"
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[
578,
605
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],
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{
"db_name": "miRNA-corpus",
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}
]
},
{
"id": "1440",
"type": "Diseases",
"text": [
"Myoclonus-dystonia syndrome"
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610,
637
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],
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"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d27.s5.e0"
}
]
},
{
"id": "1441",
"type": "Genes/Proteins",
"text": [
"epsilon-sarcoglycan"
],
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[
639,
658
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],
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{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d27.s5.e1"
}
]
}
] | [] | [] | [] |
1489 | miRNA-corp.d28 | [
{
"id": "1443",
"type": "title",
"text": [
"This review summarizes recent findings of miRNA study in brain tumors. "
],
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[
0,
73
]
]
},
{
"id": "1444",
"type": "abstract",
"text": [
"Several deregulated miRNAs uncovered in glioblastomas and medulloblastomas have their gene targets and the associated genetic pathways identified. "
],
"offsets": [
[
74,
221
]
]
},
{
"id": "1445",
"type": "abstract",
"text": [
"Moreover, specific miRNA subsets may have potential diagnostic and prognostic values in some brain tumors. "
],
"offsets": [
[
222,
329
]
]
},
{
"id": "1446",
"type": "abstract",
"text": [
"Expression profiling has unveiled miRNA signatures that not only distinguish brain tumors from normal tissues, but can also differentiate histotypes or molecular subtypes with altered genetic pathways. "
],
"offsets": [
[
330,
532
]
]
},
{
"id": "1447",
"type": "abstract",
"text": [
"Recent years have seen considerable progress in miRNA research in brain tumors, particularly in glioblastomas and medulloblastomas, providing novel insights into the pathogenesis of these malignant lesions. "
],
"offsets": [
[
533,
740
]
]
},
{
"id": "1448",
"type": "abstract",
"text": [
"Emerging evidence indicates that miRNAs play an important role in the development of human cancers, with their deregulation resulting in altered activity of downstream tumor suppressors, oncogenes and other signaling molecules. "
],
"offsets": [
[
741,
969
]
]
},
{
"id": "1449",
"type": "abstract",
"text": [
"MicroRNAs (miRNAs) are short non-protein-coding RNAs that function as key regulators of diverse biological processes through negative control on gene expression at the post-transcriptional level. "
],
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[
970,
1166
]
]
},
{
"id": "1450",
"type": "abstract",
"text": [
"Oncogenic role of microRNAs in brain tumors. "
],
"offsets": [
[
1167,
1213
]
]
}
] | [
{
"id": "1451",
"type": "Non-Specific_miRNAs",
"text": [
"miRNA"
],
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[
42,
47
]
],
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"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d28.s0.e0"
}
]
},
{
"id": "1452",
"type": "Diseases",
"text": [
"brain tumors"
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[
57,
69
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"db_id": "miRNA-corp.d28.s0.e1"
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]
},
{
"id": "1453",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
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[
94,
100
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],
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"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d28.s1.e0"
}
]
},
{
"id": "1454",
"type": "Diseases",
"text": [
"glioblastomas"
],
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[
114,
127
]
],
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"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d28.s1.e1"
}
]
},
{
"id": "1455",
"type": "Diseases",
"text": [
"medulloblastomas"
],
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[
132,
148
]
],
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{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d28.s1.e2"
}
]
},
{
"id": "1456",
"type": "Relation_Trigger",
"text": [
"targets"
],
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[
165,
172
]
],
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"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d28.s1.e3"
}
]
},
{
"id": "1457",
"type": "Relation_Trigger",
"text": [
"deregulated"
],
"offsets": [
[
82,
93
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d28.s1.e4"
}
]
},
{
"id": "1458",
"type": "Relation_Trigger",
"text": [
"associated"
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[
181,
191
]
],
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{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d28.s1.e5"
}
]
},
{
"id": "1459",
"type": "Non-Specific_miRNAs",
"text": [
"miRNA"
],
"offsets": [
[
241,
246
]
],
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{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d28.s2.e0"
}
]
},
{
"id": "1460",
"type": "Diseases",
"text": [
"brain tumors"
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"offsets": [
[
315,
327
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d28.s2.e1"
}
]
},
{
"id": "1461",
"type": "Non-Specific_miRNAs",
"text": [
"miRNA"
],
"offsets": [
[
364,
369
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d28.s3.e0"
}
]
},
{
"id": "1462",
"type": "Diseases",
"text": [
"brain tumors"
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"offsets": [
[
407,
419
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d28.s3.e1"
}
]
},
{
"id": "1463",
"type": "Non-Specific_miRNAs",
"text": [
"miRNA"
],
"offsets": [
[
581,
586
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d28.s4.e0"
}
]
},
{
"id": "1464",
"type": "Diseases",
"text": [
"brain tumors"
],
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[
599,
611
]
],
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{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d28.s4.e1"
}
]
},
{
"id": "1465",
"type": "Diseases",
"text": [
"glioblastomas"
],
"offsets": [
[
629,
642
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d28.s4.e2"
}
]
},
{
"id": "1466",
"type": "Diseases",
"text": [
"medulloblastomas"
],
"offsets": [
[
647,
663
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d28.s4.e3"
}
]
},
{
"id": "1467",
"type": "Diseases",
"text": [
"malignant lesions"
],
"offsets": [
[
721,
738
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d28.s4.e4"
}
]
},
{
"id": "1468",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
[
774,
780
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d28.s5.e0"
}
]
},
{
"id": "1469",
"type": "Diseases",
"text": [
"cancers"
],
"offsets": [
[
832,
839
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d28.s5.e1"
}
]
},
{
"id": "1470",
"type": "Relation_Trigger",
"text": [
"deregulation"
],
"offsets": [
[
852,
864
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d28.s5.e2"
}
]
},
{
"id": "1471",
"type": "Relation_Trigger",
"text": [
"tumor suppressors"
],
"offsets": [
[
909,
926
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d28.s5.e3"
}
]
},
{
"id": "1472",
"type": "Species",
"text": [
"human"
],
"offsets": [
[
826,
831
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d28.s5.e4"
}
]
},
{
"id": "1473",
"type": "Non-Specific_miRNAs",
"text": [
"MicroRNAs"
],
"offsets": [
[
970,
979
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d28.s6.e0"
}
]
},
{
"id": "1474",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
[
981,
987
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d28.s6.e1"
}
]
},
{
"id": "1475",
"type": "Relation_Trigger",
"text": [
"regulators"
],
"offsets": [
[
1044,
1054
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d28.s6.e2"
}
]
},
{
"id": "1476",
"type": "Non-Specific_miRNAs",
"text": [
"microRNAs"
],
"offsets": [
[
1185,
1194
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d28.s7.e0"
}
]
},
{
"id": "1477",
"type": "Diseases",
"text": [
"brain tumors"
],
"offsets": [
[
1198,
1210
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d28.s7.e1"
}
]
}
] | [] | [] | [
{
"id": "1478",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d28.s0.e0",
"arg2_id": "miRNA-corp.d28.s0.e1",
"normalized": []
},
{
"id": "1479",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d28.s1.e0",
"arg2_id": "miRNA-corp.d28.s1.e1",
"normalized": []
},
{
"id": "1480",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d28.s1.e0",
"arg2_id": "miRNA-corp.d28.s1.e2",
"normalized": []
},
{
"id": "1481",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d28.s2.e0",
"arg2_id": "miRNA-corp.d28.s2.e1",
"normalized": []
},
{
"id": "1482",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d28.s3.e0",
"arg2_id": "miRNA-corp.d28.s3.e1",
"normalized": []
},
{
"id": "1483",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d28.s4.e0",
"arg2_id": "miRNA-corp.d28.s4.e1",
"normalized": []
},
{
"id": "1484",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d28.s4.e0",
"arg2_id": "miRNA-corp.d28.s4.e2",
"normalized": []
},
{
"id": "1485",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d28.s4.e0",
"arg2_id": "miRNA-corp.d28.s4.e3",
"normalized": []
},
{
"id": "1486",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d28.s4.e0",
"arg2_id": "miRNA-corp.d28.s4.e4",
"normalized": []
},
{
"id": "1487",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d28.s5.e0",
"arg2_id": "miRNA-corp.d28.s5.e1",
"normalized": []
},
{
"id": "1488",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d28.s7.e0",
"arg2_id": "miRNA-corp.d28.s7.e1",
"normalized": []
}
] |
1530 | miRNA-corp.d29 | [
{
"id": "1490",
"type": "title",
"text": [
"Additionally, a control shRNA containing mismatches also induced toxicity, although it did not reduce HDh mRNA expression. "
],
"offsets": [
[
0,
123
]
]
},
{
"id": "1491",
"type": "abstract",
"text": [
"Interestingly, the toxic shRNAs generated higher antisense RNA levels, compared with the nontoxic shRNA. "
],
"offsets": [
[
124,
229
]
]
},
{
"id": "1492",
"type": "abstract",
"text": [
"These results demonstrate that the robust levels of antisense RNAs emerging from shRNA expression systems can be problematic in the mouse brain. "
],
"offsets": [
[
230,
375
]
]
},
{
"id": "1493",
"type": "abstract",
"text": [
"Importantly, when sequences that were toxic in the context of shRNAs were placed into artificial microRNA (miRNA) expression systems, molecular and neuropathological readouts of neurotoxicity were significantly attenuated without compromising mouse HDh silencing efficacy. "
],
"offsets": [
[
376,
649
]
]
},
{
"id": "1494",
"type": "abstract",
"text": [
"Artificial miRNAs mitigate shRNA-mediated toxicity in the brain: implications for the therapeutic development of RNAi. "
],
"offsets": [
[
650,
770
]
]
},
{
"id": "1495",
"type": "abstract",
"text": [
"Huntington's disease (HD) is a fatal, dominant neurodegenerative disease caused by a polyglutamine repeat expansion in exon 1 of the HD gene, which encodes the huntingtin protein. "
],
"offsets": [
[
771,
951
]
]
},
{
"id": "1496",
"type": "abstract",
"text": [
"We and others have shown that RNAi is a candidate therapy for HD because expression of inhibitory RNAs targeting mutant human HD transgenes improved neuropathology and behavioral deficits in HD mouse models. "
],
"offsets": [
[
952,
1160
]
]
},
{
"id": "1497",
"type": "abstract",
"text": [
"Here, we developed shRNAs targeting conserved sequences in human HD and mouse HD homolog (HDh) mRNAs to initiate preclinical testing in a knockin mouse model of HD. "
],
"offsets": [
[
1161,
1326
]
]
},
{
"id": "1498",
"type": "abstract",
"text": [
"Unexpectedly, two active shRNAs induced significant neurotoxicity in mouse striatum, although HDh mRNA expression was reduced to similar levels by all three. "
],
"offsets": [
[
1327,
1485
]
]
},
{
"id": "1499",
"type": "abstract",
"text": [
"Thus, miRNA-based approaches may provide more appropriate biological tools for expressing inhibitory RNAs in the brain, the implications of which are crucial to the development of RNAi for both basic biological and therapeutic applications. "
],
"offsets": [
[
1486,
1729
]
]
}
] | [
{
"id": "1500",
"type": "Relation_Trigger",
"text": [
"reduce HDh mRNA expression"
],
"offsets": [
[
95,
121
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d29.s0.e0"
}
]
},
{
"id": "1501",
"type": "Relation_Trigger",
"text": [
"higher antisense RNA levels"
],
"offsets": [
[
166,
193
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d29.s1.e0"
}
]
},
{
"id": "1502",
"type": "Species",
"text": [
"mouse"
],
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[
362,
367
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d29.s2.e0"
}
]
},
{
"id": "1503",
"type": "Non-Specific_miRNAs",
"text": [
"miRNA"
],
"offsets": [
[
483,
488
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d29.s3.e0"
}
]
},
{
"id": "1504",
"type": "Non-Specific_miRNAs",
"text": [
"microRNA"
],
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[
473,
481
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d29.s3.e1"
}
]
},
{
"id": "1505",
"type": "Relation_Trigger",
"text": [
"attenuated"
],
"offsets": [
[
587,
597
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d29.s3.e2"
}
]
},
{
"id": "1506",
"type": "Species",
"text": [
"mouse"
],
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[
619,
624
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d29.s3.e3"
}
]
},
{
"id": "1507",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
[
661,
667
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d29.s4.e0"
}
]
},
{
"id": "1508",
"type": "Diseases",
"text": [
"Huntington's disease"
],
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[
771,
791
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d29.s5.e0"
}
]
},
{
"id": "1509",
"type": "Diseases",
"text": [
"HD"
],
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[
793,
795
]
],
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{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d29.s5.e1"
}
]
},
{
"id": "1510",
"type": "Genes/Proteins",
"text": [
"huntingtin"
],
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[
931,
941
]
],
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{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d29.s5.e2"
}
]
},
{
"id": "1511",
"type": "Diseases",
"text": [
"dominant neurodegenerative disease"
],
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[
809,
843
]
],
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{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d29.s5.e3"
}
]
},
{
"id": "1512",
"type": "Diseases",
"text": [
"HD"
],
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[
1014,
1016
]
],
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{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d29.s6.e0"
}
]
},
{
"id": "1513",
"type": "Relation_Trigger",
"text": [
"inhibitory"
],
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[
1039,
1049
]
],
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{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d29.s6.e1"
}
]
},
{
"id": "1514",
"type": "Relation_Trigger",
"text": [
"targeting"
],
"offsets": [
[
1055,
1064
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d29.s6.e2"
}
]
},
{
"id": "1515",
"type": "Diseases",
"text": [
"HD"
],
"offsets": [
[
1143,
1145
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d29.s6.e3"
}
]
},
{
"id": "1516",
"type": "Species",
"text": [
"human"
],
"offsets": [
[
1072,
1077
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d29.s6.e4"
}
]
},
{
"id": "1517",
"type": "Species",
"text": [
"mouse"
],
"offsets": [
[
1146,
1151
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d29.s6.e5"
}
]
},
{
"id": "1518",
"type": "Diseases",
"text": [
"HD"
],
"offsets": [
[
1322,
1324
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d29.s7.e0"
}
]
},
{
"id": "1519",
"type": "Diseases",
"text": [
"HD"
],
"offsets": [
[
1226,
1228
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d29.s7.e1"
}
]
},
{
"id": "1520",
"type": "Diseases",
"text": [
"HD"
],
"offsets": [
[
1239,
1241
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d29.s7.e2"
}
]
},
{
"id": "1521",
"type": "Relation_Trigger",
"text": [
"targeting"
],
"offsets": [
[
1187,
1196
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d29.s7.e3"
}
]
},
{
"id": "1522",
"type": "Species",
"text": [
"human"
],
"offsets": [
[
1220,
1225
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d29.s7.e4"
}
]
},
{
"id": "1523",
"type": "Species",
"text": [
"mouse"
],
"offsets": [
[
1233,
1238
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d29.s7.e5"
}
]
},
{
"id": "1524",
"type": "Species",
"text": [
"mouse"
],
"offsets": [
[
1307,
1312
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d29.s7.e6"
}
]
},
{
"id": "1525",
"type": "Relation_Trigger",
"text": [
"expression was reduced"
],
"offsets": [
[
1430,
1452
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d29.s9.e0"
}
]
},
{
"id": "1526",
"type": "Relation_Trigger",
"text": [
"reduced to similar levels"
],
"offsets": [
[
1445,
1470
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d29.s9.e1"
}
]
},
{
"id": "1527",
"type": "Species",
"text": [
"mouse"
],
"offsets": [
[
1396,
1401
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d29.s9.e2"
}
]
},
{
"id": "1528",
"type": "Relation_Trigger",
"text": [
"inhibitory"
],
"offsets": [
[
1576,
1586
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d29.s10.e0"
}
]
},
{
"id": "1529",
"type": "Non-Specific_miRNAs",
"text": [
"miRNA"
],
"offsets": [
[
1492,
1497
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d29.s10.e1"
}
]
}
] | [] | [] | [] |
1586 | miRNA-corp.d30 | [
{
"id": "1531",
"type": "title",
"text": [
"These results are the first to demonstrate that levels of human APP can be regulated by miRNAs. "
],
"offsets": [
[
0,
98
]
]
},
{
"id": "1532",
"type": "abstract",
"text": [
"Over-expression of these miRNAs, but not control miRNAs, results in translational repression of APP mRNA and significantly reduces APP protein levels. "
],
"offsets": [
[
99,
250
]
]
},
{
"id": "1533",
"type": "abstract",
"text": [
"Here we test the hypothesis that APP protein levels can be regulated by miRNAs, evolutionarily conserved small noncoding RNA molecules that play an important role in regulating gene expression. "
],
"offsets": [
[
251,
445
]
]
},
{
"id": "1534",
"type": "abstract",
"text": [
"Utilizing human cell lines, we demonstrate that miRNAs hsa-mir-106a and hsa-mir-520c bind to their predicted target sequences in the APP 3'UTR and negatively regulate reporter gene expression. "
],
"offsets": [
[
446,
639
]
]
},
{
"id": "1535",
"type": "abstract",
"text": [
"ABSTRACT: A number of studies have shown that increased APP levels, resulting from either a genomic locus duplication or alteration in APP regulatory sequences, can lead to development of early-onset dementias, including Alzheimer's disease (AD). "
],
"offsets": [
[
640,
887
]
]
},
{
"id": "1536",
"type": "abstract",
"text": [
"Therefore, understanding how APP levels are regulated could provide valuable insight into the genetic basis of AD and illuminate novel therapeutic avenues for AD. "
],
"offsets": [
[
888,
1051
]
]
},
{
"id": "1537",
"type": "abstract",
"text": [
"MicroRNAs can regulate human APP levels. "
],
"offsets": [
[
1052,
1094
]
]
}
] | [
{
"id": "1538",
"type": "Genes/Proteins",
"text": [
"APP"
],
"offsets": [
[
64,
67
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d30.s0.e0"
}
]
},
{
"id": "1539",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
[
88,
94
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d30.s0.e1"
}
]
},
{
"id": "1540",
"type": "Relation_Trigger",
"text": [
"regulated"
],
"offsets": [
[
75,
84
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d30.s0.e2"
}
]
},
{
"id": "1541",
"type": "Species",
"text": [
"human"
],
"offsets": [
[
58,
63
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d30.s0.e3"
}
]
},
{
"id": "1542",
"type": "Genes/Proteins",
"text": [
"APP"
],
"offsets": [
[
195,
198
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d30.s1.e0"
}
]
},
{
"id": "1543",
"type": "Genes/Proteins",
"text": [
"APP"
],
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[
230,
233
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d30.s1.e1"
}
]
},
{
"id": "1544",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
[
124,
130
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d30.s1.e2"
}
]
},
{
"id": "1545",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
[
148,
154
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d30.s1.e3"
}
]
},
{
"id": "1546",
"type": "Relation_Trigger",
"text": [
"Over-expression"
],
"offsets": [
[
99,
114
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d30.s1.e4"
}
]
},
{
"id": "1547",
"type": "Relation_Trigger",
"text": [
"translational repression"
],
"offsets": [
[
167,
191
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d30.s1.e5"
}
]
},
{
"id": "1548",
"type": "Relation_Trigger",
"text": [
"reduces APP protein levels"
],
"offsets": [
[
222,
248
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d30.s1.e6"
}
]
},
{
"id": "1549",
"type": "Genes/Proteins",
"text": [
"APP"
],
"offsets": [
[
284,
287
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d30.s2.e0"
}
]
},
{
"id": "1550",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
[
323,
329
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d30.s2.e1"
}
]
},
{
"id": "1551",
"type": "Relation_Trigger",
"text": [
"levels can be regulated"
],
"offsets": [
[
296,
319
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d30.s2.e2"
}
]
},
{
"id": "1552",
"type": "Relation_Trigger",
"text": [
"regulating gene expression"
],
"offsets": [
[
417,
443
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d30.s2.e3"
}
]
},
{
"id": "1553",
"type": "Genes/Proteins",
"text": [
"APP"
],
"offsets": [
[
579,
582
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d30.s3.e0"
}
]
},
{
"id": "1554",
"type": "Specific_miRNAs",
"text": [
"hsa-mir-106a"
],
"offsets": [
[
501,
513
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d30.s3.e1"
}
]
},
{
"id": "1555",
"type": "Specific_miRNAs",
"text": [
"hsa-mir-520c"
],
"offsets": [
[
518,
530
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d30.s3.e2"
}
]
},
{
"id": "1556",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
[
494,
500
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d30.s3.e3"
}
]
},
{
"id": "1557",
"type": "Relation_Trigger",
"text": [
"bind"
],
"offsets": [
[
531,
535
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d30.s3.e4"
}
]
},
{
"id": "1558",
"type": "Relation_Trigger",
"text": [
"regulate reporter gene expression"
],
"offsets": [
[
604,
637
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d30.s3.e5"
}
]
},
{
"id": "1559",
"type": "Relation_Trigger",
"text": [
"target"
],
"offsets": [
[
555,
561
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d30.s3.e6"
}
]
},
{
"id": "1560",
"type": "Relation_Trigger",
"text": [
"negatively regulate"
],
"offsets": [
[
593,
612
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d30.s3.e7"
}
]
},
{
"id": "1561",
"type": "Species",
"text": [
"human"
],
"offsets": [
[
456,
461
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d30.s3.e8"
}
]
},
{
"id": "1562",
"type": "Genes/Proteins",
"text": [
"APP"
],
"offsets": [
[
696,
699
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d30.s4.e0"
}
]
},
{
"id": "1563",
"type": "Diseases",
"text": [
"dementias"
],
"offsets": [
[
840,
849
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d30.s4.e1"
}
]
},
{
"id": "1564",
"type": "Diseases",
"text": [
"Alzheimer's disease"
],
"offsets": [
[
861,
880
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d30.s4.e2"
}
]
},
{
"id": "1565",
"type": "Diseases",
"text": [
"AD"
],
"offsets": [
[
882,
884
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d30.s4.e3"
}
]
},
{
"id": "1566",
"type": "Relation_Trigger",
"text": [
"increased APP levels"
],
"offsets": [
[
686,
706
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d30.s4.e4"
}
]
},
{
"id": "1567",
"type": "Relation_Trigger",
"text": [
"regulatory"
],
"offsets": [
[
779,
789
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d30.s4.e5"
}
]
},
{
"id": "1568",
"type": "Diseases",
"text": [
"AD"
],
"offsets": [
[
1047,
1049
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d30.s5.e0"
}
]
},
{
"id": "1569",
"type": "Diseases",
"text": [
"AD"
],
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[
999,
1001
]
],
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{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d30.s5.e1"
}
]
},
{
"id": "1570",
"type": "Genes/Proteins",
"text": [
"APP"
],
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917,
920
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],
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{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d30.s5.e2"
}
]
},
{
"id": "1571",
"type": "Relation_Trigger",
"text": [
"levels are regulated"
],
"offsets": [
[
921,
941
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d30.s5.e3"
}
]
},
{
"id": "1572",
"type": "Genes/Proteins",
"text": [
"APP"
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1081,
1084
]
],
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{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d30.s6.e0"
}
]
},
{
"id": "1573",
"type": "Non-Specific_miRNAs",
"text": [
"MicroRNAs"
],
"offsets": [
[
1052,
1061
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d30.s6.e1"
}
]
},
{
"id": "1574",
"type": "Relation_Trigger",
"text": [
"regulate human APP levels"
],
"offsets": [
[
1066,
1091
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d30.s6.e2"
}
]
},
{
"id": "1575",
"type": "Species",
"text": [
"human"
],
"offsets": [
[
1075,
1080
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d30.s6.e3"
}
]
}
] | [] | [] | [
{
"id": "1576",
"type": "Non-Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d30.s0.e1",
"arg2_id": "miRNA-corp.d30.s0.e0",
"normalized": []
},
{
"id": "1577",
"type": "Non-Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d30.s1.e2",
"arg2_id": "miRNA-corp.d30.s1.e0",
"normalized": []
},
{
"id": "1578",
"type": "Non-Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d30.s1.e2",
"arg2_id": "miRNA-corp.d30.s1.e1",
"normalized": []
},
{
"id": "1579",
"type": "Non-Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d30.s1.e3",
"arg2_id": "miRNA-corp.d30.s1.e0",
"normalized": []
},
{
"id": "1580",
"type": "Non-Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d30.s1.e3",
"arg2_id": "miRNA-corp.d30.s1.e1",
"normalized": []
},
{
"id": "1581",
"type": "Non-Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d30.s2.e1",
"arg2_id": "miRNA-corp.d30.s2.e0",
"normalized": []
},
{
"id": "1582",
"type": "Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d30.s3.e1",
"arg2_id": "miRNA-corp.d30.s3.e0",
"normalized": []
},
{
"id": "1583",
"type": "Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d30.s3.e2",
"arg2_id": "miRNA-corp.d30.s3.e0",
"normalized": []
},
{
"id": "1584",
"type": "Non-Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d30.s3.e3",
"arg2_id": "miRNA-corp.d30.s3.e0",
"normalized": []
},
{
"id": "1585",
"type": "Non-Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d30.s6.e1",
"arg2_id": "miRNA-corp.d30.s6.e0",
"normalized": []
}
] |
1638 | miRNA-corp.d31 | [
{
"id": "1587",
"type": "title",
"text": [
"Predictive miRNAs could be potentially useful diagnostic markers, improving the classification of pituitary adenomas. "
],
"offsets": [
[
0,
120
]
]
},
{
"id": "1588",
"type": "abstract",
"text": [
"Several of the identified miRNAs are involved in cell proliferation and apoptosis, suggesting that their deregulated expression may be involved in pituitary tumorigenesis. "
],
"offsets": [
[
121,
293
]
]
},
{
"id": "1589",
"type": "abstract",
"text": [
"Identification of differentially expressed microRNAs by microarray: a possible role for microRNA genes in pituitary adenomas. "
],
"offsets": [
[
294,
421
]
]
},
{
"id": "1590",
"type": "abstract",
"text": [
"MicroRNAs (miRNAs) are small non-coding RNAs that control gene expression by targeting mRNA. "
],
"offsets": [
[
422,
515
]
]
},
{
"id": "1591",
"type": "abstract",
"text": [
"It has been demonstrated that miRNA expression is altered in many human cancers, suggesting that they may play a role in human neoplasia. "
],
"offsets": [
[
516,
654
]
]
},
{
"id": "1592",
"type": "abstract",
"text": [
"To determine whether miRNA expression is altered in pituitary adenomas, we analyzed the entire miRNAome in 32 pituitary adenomas and in 6 normal pituitary samples by microarray and by Real-Time PCR. "
],
"offsets": [
[
655,
854
]
]
},
{
"id": "1593",
"type": "abstract",
"text": [
"Here, we show that 30 miRNAs are differentially expressed between normal pituitary and pituitary adenomas. "
],
"offsets": [
[
855,
962
]
]
},
{
"id": "1594",
"type": "abstract",
"text": [
"Moreover, 24 miRNAs were identified as a predictive signature of pituitary adenoma and 29 miRNAs were able to predict pituitary adenoma histotype. "
],
"offsets": [
[
963,
1110
]
]
},
{
"id": "1595",
"type": "abstract",
"text": [
"miRNA expression could differentiate micro- from macro-adenomas and treated from non-treated patient samples. "
],
"offsets": [
[
1111,
1221
]
]
}
] | [
{
"id": "1596",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
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11,
17
]
],
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{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d31.s0.e0"
}
]
},
{
"id": "1597",
"type": "Diseases",
"text": [
"pituitary adenomas"
],
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98,
116
]
],
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{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d31.s0.e1"
}
]
},
{
"id": "1598",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
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[
147,
153
]
],
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{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d31.s1.e0"
}
]
},
{
"id": "1599",
"type": "Relation_Trigger",
"text": [
"deregulated expression"
],
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[
226,
248
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d31.s1.e1"
}
]
},
{
"id": "1600",
"type": "Non-Specific_miRNAs",
"text": [
"microRNAs"
],
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[
337,
346
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d31.s2.e0"
}
]
},
{
"id": "1601",
"type": "Non-Specific_miRNAs",
"text": [
"microRNA"
],
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[
382,
390
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d31.s2.e1"
}
]
},
{
"id": "1602",
"type": "Diseases",
"text": [
"pituitary adenomas"
],
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[
400,
418
]
],
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{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d31.s2.e2"
}
]
},
{
"id": "1603",
"type": "Relation_Trigger",
"text": [
"differentially expressed"
],
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[
312,
336
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d31.s2.e3"
}
]
},
{
"id": "1604",
"type": "Non-Specific_miRNAs",
"text": [
"MicroRNAs"
],
"offsets": [
[
422,
431
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d31.s3.e0"
}
]
},
{
"id": "1605",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
[
433,
439
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d31.s3.e1"
}
]
},
{
"id": "1606",
"type": "Relation_Trigger",
"text": [
"targeting"
],
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[
499,
508
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d31.s3.e2"
}
]
},
{
"id": "1607",
"type": "Non-Specific_miRNAs",
"text": [
"miRNA"
],
"offsets": [
[
546,
551
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d31.s4.e0"
}
]
},
{
"id": "1608",
"type": "Relation_Trigger",
"text": [
"expression is altered"
],
"offsets": [
[
552,
573
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d31.s4.e1"
}
]
},
{
"id": "1609",
"type": "Diseases",
"text": [
"cancers"
],
"offsets": [
[
588,
595
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d31.s4.e2"
}
]
},
{
"id": "1610",
"type": "Species",
"text": [
"human"
],
"offsets": [
[
582,
587
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d31.s4.e3"
}
]
},
{
"id": "1611",
"type": "Species",
"text": [
"human"
],
"offsets": [
[
637,
642
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d31.s4.e4"
}
]
},
{
"id": "1612",
"type": "Non-Specific_miRNAs",
"text": [
"miRNA"
],
"offsets": [
[
676,
681
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d31.s5.e0"
}
]
},
{
"id": "1613",
"type": "Diseases",
"text": [
"pituitary adenomas"
],
"offsets": [
[
707,
725
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d31.s5.e1"
}
]
},
{
"id": "1614",
"type": "Diseases",
"text": [
"pituitary adenomas"
],
"offsets": [
[
765,
783
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d31.s5.e2"
}
]
},
{
"id": "1615",
"type": "Relation_Trigger",
"text": [
"expression is altered"
],
"offsets": [
[
682,
703
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d31.s5.e3"
}
]
},
{
"id": "1616",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
[
877,
883
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d31.s6.e0"
}
]
},
{
"id": "1617",
"type": "Diseases",
"text": [
"pituitary adenomas"
],
"offsets": [
[
942,
960
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d31.s6.e1"
}
]
},
{
"id": "1618",
"type": "Relation_Trigger",
"text": [
"differentially expressed"
],
"offsets": [
[
888,
912
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d31.s6.e2"
}
]
},
{
"id": "1619",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
[
976,
982
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d31.s7.e0"
}
]
},
{
"id": "1620",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
[
1053,
1059
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d31.s7.e1"
}
]
},
{
"id": "1621",
"type": "Diseases",
"text": [
"pituitary adenoma"
],
"offsets": [
[
1028,
1045
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d31.s7.e2"
}
]
},
{
"id": "1622",
"type": "Diseases",
"text": [
"pituitary adenoma"
],
"offsets": [
[
1081,
1098
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d31.s7.e3"
}
]
},
{
"id": "1623",
"type": "Non-Specific_miRNAs",
"text": [
"miRNA"
],
"offsets": [
[
1111,
1116
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d31.s8.e0"
}
]
},
{
"id": "1624",
"type": "Diseases",
"text": [
"adenomas"
],
"offsets": [
[
1166,
1174
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d31.s8.e1"
}
]
},
{
"id": "1625",
"type": "Species",
"text": [
"patient"
],
"offsets": [
[
1204,
1211
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d31.s8.e2"
}
]
}
] | [] | [] | [
{
"id": "1626",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d31.s0.e0",
"arg2_id": "miRNA-corp.d31.s0.e1",
"normalized": []
},
{
"id": "1627",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d31.s2.e0",
"arg2_id": "miRNA-corp.d31.s2.e2",
"normalized": []
},
{
"id": "1628",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d31.s2.e1",
"arg2_id": "miRNA-corp.d31.s2.e2",
"normalized": []
},
{
"id": "1629",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d31.s4.e0",
"arg2_id": "miRNA-corp.d31.s4.e2",
"normalized": []
},
{
"id": "1630",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d31.s5.e0",
"arg2_id": "miRNA-corp.d31.s5.e1",
"normalized": []
},
{
"id": "1631",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d31.s5.e0",
"arg2_id": "miRNA-corp.d31.s5.e2",
"normalized": []
},
{
"id": "1632",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d31.s6.e0",
"arg2_id": "miRNA-corp.d31.s6.e1",
"normalized": []
},
{
"id": "1633",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d31.s7.e0",
"arg2_id": "miRNA-corp.d31.s7.e2",
"normalized": []
},
{
"id": "1634",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d31.s7.e0",
"arg2_id": "miRNA-corp.d31.s7.e3",
"normalized": []
},
{
"id": "1635",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d31.s7.e1",
"arg2_id": "miRNA-corp.d31.s7.e2",
"normalized": []
},
{
"id": "1636",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d31.s7.e1",
"arg2_id": "miRNA-corp.d31.s7.e3",
"normalized": []
},
{
"id": "1637",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d31.s8.e0",
"arg2_id": "miRNA-corp.d31.s8.e1",
"normalized": []
}
] |
1687 | miRNA-corp.d32 | [
{
"id": "1639",
"type": "title",
"text": [
"Comparison of mouse cerebellar development and medulloblastoma demonstrates a shared miRNA-mRNA co-expression program for brain-specific neurologic processes such as synaptic transmission and exocytosis, in which miRNA target expression increases with the accumulation of multiple miRNAs in developing cerebellum and decreases with the loss of these miRNAs in brain tumors. "
],
"offsets": [
[
0,
374
]
]
},
{
"id": "1640",
"type": "abstract",
"text": [
"These findings demonstrate the context-dependence of miRNA-mRNA co-expression. "
],
"offsets": [
[
375,
456
]
]
},
{
"id": "1641",
"type": "abstract",
"text": [
"Although miRNAs in general suppress target mRNA messages, many predicted miRNA targets demonstrate a significantly higher level of co-expression than non-target genes in developing cerebellum. "
],
"offsets": [
[
457,
650
]
]
},
{
"id": "1642",
"type": "abstract",
"text": [
"Towards that goal, we examined miRNA-mRNA interactions by measuring miRNA and mRNA in the same tissue during development and also in malignant conditions. "
],
"offsets": [
[
651,
806
]
]
},
{
"id": "1643",
"type": "abstract",
"text": [
"We identified significant miRNA-mediated biological process categories in developing mouse cerebellum and lung using non-targeted mRNA expression as the negative control. "
],
"offsets": [
[
807,
978
]
]
},
{
"id": "1644",
"type": "abstract",
"text": [
"Tissue and process specific microRNA-mRNA co-expression in mammalian development and malignancy. "
],
"offsets": [
[
979,
1077
]
]
},
{
"id": "1645",
"type": "abstract",
"text": [
"An association between enrichment and depletion of microRNA (miRNA) binding sites, 3' UTR length, and mRNA expression has been demonstrated in various developing tissues and tissues from different mature organs; but functional, context-dependent miRNA regulations have yet to be elucidated. "
],
"offsets": [
[
1078,
1369
]
]
}
] | [
{
"id": "1646",
"type": "Diseases",
"text": [
"medulloblastoma"
],
"offsets": [
[
47,
62
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d32.s0.e0"
}
]
},
{
"id": "1647",
"type": "Diseases",
"text": [
"brain tumors"
],
"offsets": [
[
360,
372
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d32.s0.e1"
}
]
},
{
"id": "1648",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
[
281,
287
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d32.s0.e2"
}
]
},
{
"id": "1649",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
[
350,
356
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d32.s0.e3"
}
]
},
{
"id": "1650",
"type": "Non-Specific_miRNAs",
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] | [] | [] | [
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] |
1751 | miRNA-corp.d33 | [
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},
{
"id": "1725",
"type": "Specific_miRNAs",
"text": [
"miR-9"
],
"offsets": [
[
834,
839
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d33.s6.e4"
}
]
},
{
"id": "1726",
"type": "Relation_Trigger",
"text": [
"targets"
],
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767,
774
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d33.s6.e5"
}
]
},
{
"id": "1727",
"type": "Relation_Trigger",
"text": [
"targets"
],
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[
817,
824
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d33.s6.e6"
}
]
},
{
"id": "1728",
"type": "Relation_Trigger",
"text": [
"targets"
],
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[
841,
848
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d33.s6.e7"
}
]
},
{
"id": "1729",
"type": "Genes/Proteins",
"text": [
"REST"
],
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[
825,
829
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d33.s6.e8"
}
]
},
{
"id": "1730",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
[
965,
971
]
],
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{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d33.s7.e0"
}
]
},
{
"id": "1731",
"type": "Relation_Trigger",
"text": [
"regulates"
],
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[
975,
984
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],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d33.s7.e1"
}
]
}
] | [] | [] | [
{
"id": "1732",
"type": "Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d33.s1.e0",
"arg2_id": "miRNA-corp.d33.s1.e1",
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},
{
"id": "1733",
"type": "Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d33.s1.e0",
"arg2_id": "miRNA-corp.d33.s1.e2",
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},
{
"id": "1734",
"type": "Specific_miRNAs-Diseases",
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"arg2_id": "miRNA-corp.d33.s1.e3",
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},
{
"id": "1735",
"type": "Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d33.s1.e4",
"arg2_id": "miRNA-corp.d33.s1.e1",
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},
{
"id": "1736",
"type": "Specific_miRNAs-Genes/Proteins",
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"arg2_id": "miRNA-corp.d33.s1.e2",
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},
{
"id": "1737",
"type": "Specific_miRNAs-Diseases",
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"arg2_id": "miRNA-corp.d33.s1.e3",
"normalized": []
},
{
"id": "1738",
"type": "Non-Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d33.s1.e5",
"arg2_id": "miRNA-corp.d33.s1.e1",
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},
{
"id": "1739",
"type": "Non-Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d33.s1.e5",
"arg2_id": "miRNA-corp.d33.s1.e2",
"normalized": []
},
{
"id": "1740",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d33.s1.e5",
"arg2_id": "miRNA-corp.d33.s1.e3",
"normalized": []
},
{
"id": "1741",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d33.s4.e1",
"arg2_id": "miRNA-corp.d33.s4.e0",
"normalized": []
},
{
"id": "1742",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d33.s4.e2",
"arg2_id": "miRNA-corp.d33.s4.e0",
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},
{
"id": "1743",
"type": "Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d33.s6.e2",
"arg2_id": "miRNA-corp.d33.s6.e8",
"normalized": []
},
{
"id": "1744",
"type": "Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d33.s6.e2",
"arg2_id": "miRNA-corp.d33.s6.e0",
"normalized": []
},
{
"id": "1745",
"type": "Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d33.s6.e3",
"arg2_id": "miRNA-corp.d33.s6.e8",
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},
{
"id": "1746",
"type": "Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d33.s6.e3",
"arg2_id": "miRNA-corp.d33.s6.e0",
"normalized": []
},
{
"id": "1747",
"type": "Specific_miRNAs-Genes/Proteins",
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"arg2_id": "miRNA-corp.d33.s6.e8",
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},
{
"id": "1748",
"type": "Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d33.s6.e4",
"arg2_id": "miRNA-corp.d33.s6.e0",
"normalized": []
},
{
"id": "1749",
"type": "Specific_miRNAs-Genes/Proteins",
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"arg2_id": "miRNA-corp.d33.s6.e8",
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},
{
"id": "1750",
"type": "Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d33.s6.e1",
"arg2_id": "miRNA-corp.d33.s6.e0",
"normalized": []
}
] |
1811 | miRNA-corp.d34 | [
{
"id": "1752",
"type": "title",
"text": [
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],
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0,
172
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]
},
{
"id": "1753",
"type": "abstract",
"text": [
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],
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173,
264
]
]
},
{
"id": "1754",
"type": "abstract",
"text": [
"MicroRNAs (miRNAs) are a recently discovered class of endogenous, small, noncoding RNAs that regulate about 30% of the encoding genes of the human genome. "
],
"offsets": [
[
265,
420
]
]
},
{
"id": "1755",
"type": "abstract",
"text": [
"MicroRNA expression signature and antisense-mediated depletion reveal an essential role of MicroRNA in vascular neointimal lesion formation. "
],
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421,
563
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]
},
{
"id": "1756",
"type": "abstract",
"text": [
"Western blot analysis demonstrated that PTEN and Bcl-2 were involved in miR-21-mediated cellular effects. "
],
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564,
670
]
]
},
{
"id": "1757",
"type": "abstract",
"text": [
"MiR-21-mediated cellular effects were further confirmed in vivo in balloon-injured rat carotid arteries. "
],
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[
671,
776
]
]
},
{
"id": "1758",
"type": "abstract",
"text": [
"Depletion of miR-21 resulted in decreased cell proliferation and increased cell apoptosis in a dose-dependent manner. "
],
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777,
895
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]
},
{
"id": "1759",
"type": "abstract",
"text": [
"In vitro, the expression level of miR-21 in dedifferentiated vascular smooth muscle cells was significantly higher than that in fresh isolated differentiated cells. "
],
"offsets": [
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896,
1061
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]
},
{
"id": "1760",
"type": "abstract",
"text": [
"Modulating an aberrantly overexpressed miRNA, miR-21, via antisense-mediated depletion (knock-down) had a significant negative effect on neointimal lesion formation. "
],
"offsets": [
[
1062,
1228
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]
},
{
"id": "1761",
"type": "abstract",
"text": [
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],
"offsets": [
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1229,
1355
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]
},
{
"id": "1762",
"type": "abstract",
"text": [
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],
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1356,
1499
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]
},
{
"id": "1763",
"type": "abstract",
"text": [
"However, the role of miRNAs in vascular disease is currently completely unknown. "
],
"offsets": [
[
1500,
1581
]
]
}
] | [
{
"id": "1764",
"type": "Diseases",
"text": [
"stroke"
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162,
168
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{
"id": "1765",
"type": "Non-Specific_miRNAs",
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0,
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},
{
"id": "1766",
"type": "Diseases",
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83,
98
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]
},
{
"id": "1767",
"type": "Relation_Trigger",
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20,
38
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],
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}
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},
{
"id": "1768",
"type": "Diseases",
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57,
74
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}
]
},
{
"id": "1769",
"type": "Diseases",
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144,
156
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]
},
{
"id": "1770",
"type": "Non-Specific_miRNAs",
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198,
204
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]
},
{
"id": "1771",
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215,
225
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"db_id": "miRNA-corp.d34.s1.e1"
}
]
},
{
"id": "1772",
"type": "Diseases",
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235,
252
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],
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"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d34.s1.e2"
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]
},
{
"id": "1773",
"type": "Non-Specific_miRNAs",
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265,
274
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],
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"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d34.s2.e0"
}
]
},
{
"id": "1774",
"type": "Non-Specific_miRNAs",
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276,
282
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],
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"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d34.s2.e1"
}
]
},
{
"id": "1775",
"type": "Relation_Trigger",
"text": [
"regulate"
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358,
366
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}
]
},
{
"id": "1776",
"type": "Species",
"text": [
"human"
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[
406,
411
]
],
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"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d34.s2.e3"
}
]
},
{
"id": "1777",
"type": "Non-Specific_miRNAs",
"text": [
"MicroRNA"
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[
421,
429
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],
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"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d34.s3.e0"
}
]
},
{
"id": "1778",
"type": "Non-Specific_miRNAs",
"text": [
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512,
520
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"db_name": "miRNA-corpus",
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}
]
},
{
"id": "1779",
"type": "Diseases",
"text": [
"vascular neointimal lesion"
],
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[
524,
550
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],
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"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d34.s3.e2"
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]
},
{
"id": "1780",
"type": "Genes/Proteins",
"text": [
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[
604,
608
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],
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"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d34.s4.e0"
}
]
},
{
"id": "1781",
"type": "Genes/Proteins",
"text": [
"Bcl-2"
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[
613,
618
]
],
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{
"db_name": "miRNA-corpus",
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}
]
},
{
"id": "1782",
"type": "Specific_miRNAs",
"text": [
"miR-21"
],
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[
636,
642
]
],
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{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d34.s4.e2"
}
]
},
{
"id": "1783",
"type": "Specific_miRNAs",
"text": [
"MiR-21"
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[
671,
677
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d34.s5.e0"
}
]
},
{
"id": "1784",
"type": "Species",
"text": [
"rat"
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"offsets": [
[
754,
757
]
],
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{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d34.s5.e1"
}
]
},
{
"id": "1785",
"type": "Specific_miRNAs",
"text": [
"miR-21"
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"offsets": [
[
790,
796
]
],
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{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d34.s6.e0"
}
]
},
{
"id": "1786",
"type": "Specific_miRNAs",
"text": [
"miR-21"
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[
930,
936
]
],
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{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d34.s7.e0"
}
]
},
{
"id": "1787",
"type": "Specific_miRNAs",
"text": [
"miR-21"
],
"offsets": [
[
1108,
1114
]
],
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{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d34.s8.e0"
}
]
},
{
"id": "1788",
"type": "Non-Specific_miRNAs",
"text": [
"miRNA"
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"offsets": [
[
1101,
1106
]
],
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{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d34.s8.e1"
}
]
},
{
"id": "1789",
"type": "Relation_Trigger",
"text": [
"aberrantly overexpressed"
],
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[
1076,
1100
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d34.s8.e2"
}
]
},
{
"id": "1790",
"type": "Diseases",
"text": [
"neointimal lesion"
],
"offsets": [
[
1199,
1216
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d34.s8.e3"
}
]
},
{
"id": "1791",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
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[
1254,
1260
]
],
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{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d34.s9.e0"
}
]
},
{
"id": "1792",
"type": "Relation_Trigger",
"text": [
"aberrantly expressed"
],
"offsets": [
[
1233,
1253
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d34.s9.e1"
}
]
},
{
"id": "1793",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
[
1423,
1429
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d34.s10.e0"
}
]
},
{
"id": "1794",
"type": "Diseases",
"text": [
"balloon injury"
],
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[
1483,
1497
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d34.s10.e1"
}
]
},
{
"id": "1795",
"type": "Relation_Trigger",
"text": [
"aberrantly expressed"
],
"offsets": [
[
1434,
1454
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],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d34.s10.e2"
}
]
},
{
"id": "1796",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
[
1521,
1527
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d34.s11.e0"
}
]
},
{
"id": "1797",
"type": "Diseases",
"text": [
"vascular disease"
],
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1531,
1547
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d34.s11.e1"
}
]
}
] | [] | [] | [
{
"id": "1798",
"type": "Non-Specific_miRNAs-Diseases",
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"arg2_id": "miRNA-corp.d34.s0.e0",
"normalized": []
},
{
"id": "1799",
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},
{
"id": "1800",
"type": "Non-Specific_miRNAs-Diseases",
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},
{
"id": "1801",
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{
"id": "1802",
"type": "Non-Specific_miRNAs-Diseases",
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},
{
"id": "1803",
"type": "Non-Specific_miRNAs-Diseases",
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{
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"type": "Non-Specific_miRNAs-Diseases",
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{
"id": "1805",
"type": "Specific_miRNAs-Genes/Proteins",
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},
{
"id": "1806",
"type": "Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d34.s4.e2",
"arg2_id": "miRNA-corp.d34.s4.e1",
"normalized": []
},
{
"id": "1807",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d34.s8.e1",
"arg2_id": "miRNA-corp.d34.s8.e3",
"normalized": []
},
{
"id": "1808",
"type": "Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d34.s8.e0",
"arg2_id": "miRNA-corp.d34.s8.e3",
"normalized": []
},
{
"id": "1809",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d34.s10.e0",
"arg2_id": "miRNA-corp.d34.s10.e1",
"normalized": []
},
{
"id": "1810",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d34.s11.e0",
"arg2_id": "miRNA-corp.d34.s11.e1",
"normalized": []
}
] |
1815 | miRNA-corp.d35 | [
{
"id": "1812",
"type": "title",
"text": [
"Point mutations in exon 1 of the NR4A2 gene are not a major cause of familial Parkinson's disease. "
],
"offsets": [
[
0,
103
]
]
}
] | [
{
"id": "1813",
"type": "Diseases",
"text": [
"familial Parkinson's disease"
],
"offsets": [
[
69,
97
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d35.s0.e0"
}
]
},
{
"id": "1814",
"type": "Genes/Proteins",
"text": [
"NR4A2"
],
"offsets": [
[
33,
38
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d35.s0.e1"
}
]
}
] | [] | [] | [] |
1883 | miRNA-corp.d36 | [
{
"id": "1816",
"type": "title",
"text": [
"In a pilot study we could show that hsa-miR-342-3p was also upregulated in brain samples of human type 1 and type 2 sporadic CJD. "
],
"offsets": [
[
0,
130
]
]
},
{
"id": "1817",
"type": "abstract",
"text": [
"Our study revealed significant upregulation of hsa-miR-342-3p and hsa-miR-494 in the brains of BSE-infected macaques compared to non-infected animals. "
],
"offsets": [
[
131,
282
]
]
},
{
"id": "1818",
"type": "abstract",
"text": [
"Shock-frozen brain sections of six BSE-infected and five non-infected macaques were used to validate regulated miRNA candidates by two independent qRT-PCR-based methods. "
],
"offsets": [
[
283,
453
]
]
},
{
"id": "1819",
"type": "abstract",
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"We have applied miRNA-microarrays to identify deregulated miRNA candidates in brains of BSE-infected macaques. "
],
"offsets": [
[
454,
565
]
]
},
{
"id": "1820",
"type": "abstract",
"text": [
"Therefore, we hypothesized that miRNAs are also regulated in response to human prion disease. "
],
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566,
660
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]
},
{
"id": "1821",
"type": "abstract",
"text": [
"Recently, the lack of miRNA processing has been shown to promote neurodegeneration and deregulation of several miRNAs has been reported to be associated with Scrapie in mice. "
],
"offsets": [
[
661,
836
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]
},
{
"id": "1822",
"type": "abstract",
"text": [
"ABSTRACT: The aim of our study was to analyze the differential expression of miRNAs in the brains of BSE-infected cynomolgus macaques as a model for Creutzfeldt-Jakob disease (CJD). "
],
"offsets": [
[
837,
1019
]
]
},
{
"id": "1823",
"type": "abstract",
"text": [
"MicroRNAs (miRNAs) are small noncoding RNAs regulating gene expression by mRNA targeting. "
],
"offsets": [
[
1020,
1110
]
]
},
{
"id": "1824",
"type": "abstract",
"text": [
"Upregulation of miRNA hsa-miR-342-3p in experimental and idiopathic prion disease. "
],
"offsets": [
[
1111,
1195
]
]
},
{
"id": "1825",
"type": "abstract",
"text": [
"With respect to the reported regulation of this miRNA in Scrapie-infected mice, we propose that upregulation of hsa-miR-342-3p may be a general phenomenon in late stage prion disease and might be used as a novel marker for animal and human TSEs. "
],
"offsets": [
[
1196,
1444
]
]
}
] | [
{
"id": "1826",
"type": "Specific_miRNAs",
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"hsa-miR-342-3p"
],
"offsets": [
[
36,
50
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d36.s0.e0"
}
]
},
{
"id": "1827",
"type": "Relation_Trigger",
"text": [
"upregulated"
],
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[
60,
71
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d36.s0.e1"
}
]
},
{
"id": "1828",
"type": "Diseases",
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"type 2 sporadic CJD"
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[
109,
128
]
],
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{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d36.s0.e2"
}
]
},
{
"id": "1829",
"type": "Species",
"text": [
"human"
],
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92,
97
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],
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}
]
},
{
"id": "1830",
"type": "Specific_miRNAs",
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"hsa-miR-342-3p"
],
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178,
192
]
],
"normalized": [
{
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"db_id": "miRNA-corp.d36.s1.e0"
}
]
},
{
"id": "1831",
"type": "Specific_miRNAs",
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"hsa-miR-494"
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[
197,
208
]
],
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{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d36.s1.e1"
}
]
},
{
"id": "1832",
"type": "Relation_Trigger",
"text": [
"upregulation"
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162,
174
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],
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{
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]
},
{
"id": "1833",
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"text": [
"miRNA"
],
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394,
399
]
],
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{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d36.s2.e0"
}
]
},
{
"id": "1834",
"type": "Relation_Trigger",
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"regulated"
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[
384,
393
]
],
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{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d36.s2.e1"
}
]
},
{
"id": "1835",
"type": "Non-Specific_miRNAs",
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"miRNA"
],
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[
512,
517
]
],
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{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d36.s3.e0"
}
]
},
{
"id": "1836",
"type": "Relation_Trigger",
"text": [
"deregulated"
],
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[
500,
511
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d36.s3.e1"
}
]
},
{
"id": "1837",
"type": "Non-Specific_miRNAs",
"text": [
"miRNA"
],
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470,
475
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d36.s3.e2"
}
]
},
{
"id": "1838",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
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598,
604
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d36.s4.e0"
}
]
},
{
"id": "1839",
"type": "Relation_Trigger",
"text": [
"regulated"
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[
614,
623
]
],
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{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d36.s4.e1"
}
]
},
{
"id": "1840",
"type": "Diseases",
"text": [
"prion disease"
],
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645,
658
]
],
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{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d36.s4.e2"
}
]
},
{
"id": "1841",
"type": "Species",
"text": [
"human"
],
"offsets": [
[
639,
644
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d36.s4.e3"
}
]
},
{
"id": "1842",
"type": "Non-Specific_miRNAs",
"text": [
"miRNA"
],
"offsets": [
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683,
688
]
],
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{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d36.s6.e0"
}
]
},
{
"id": "1843",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
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772,
778
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d36.s6.e1"
}
]
},
{
"id": "1844",
"type": "Diseases",
"text": [
"Scrapie"
],
"offsets": [
[
819,
826
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d36.s6.e2"
}
]
},
{
"id": "1845",
"type": "Relation_Trigger",
"text": [
"deregulation"
],
"offsets": [
[
748,
760
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d36.s6.e3"
}
]
},
{
"id": "1846",
"type": "Relation_Trigger",
"text": [
"associated"
],
"offsets": [
[
803,
813
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d36.s6.e4"
}
]
},
{
"id": "1847",
"type": "Species",
"text": [
"mice"
],
"offsets": [
[
830,
834
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d36.s6.e5"
}
]
},
{
"id": "1848",
"type": "Diseases",
"text": [
"Creutzfeldt-Jakob disease"
],
"offsets": [
[
986,
1011
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d36.s7.e0"
}
]
},
{
"id": "1849",
"type": "Diseases",
"text": [
"CJD"
],
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1013,
1016
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d36.s7.e1"
}
]
},
{
"id": "1850",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
[
914,
920
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d36.s7.e2"
}
]
},
{
"id": "1851",
"type": "Relation_Trigger",
"text": [
"differential expression"
],
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[
887,
910
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d36.s7.e3"
}
]
},
{
"id": "1852",
"type": "Non-Specific_miRNAs",
"text": [
"MicroRNAs"
],
"offsets": [
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1020,
1029
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d36.s8.e0"
}
]
},
{
"id": "1853",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
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1031,
1037
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d36.s8.e1"
}
]
},
{
"id": "1854",
"type": "Relation_Trigger",
"text": [
"regulating gene expression"
],
"offsets": [
[
1064,
1090
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d36.s8.e2"
}
]
},
{
"id": "1855",
"type": "Relation_Trigger",
"text": [
"targeting"
],
"offsets": [
[
1099,
1108
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d36.s8.e3"
}
]
},
{
"id": "1856",
"type": "Specific_miRNAs",
"text": [
"hsa-miR-342-3p"
],
"offsets": [
[
1133,
1147
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d36.s9.e0"
}
]
},
{
"id": "1857",
"type": "Diseases",
"text": [
"prion disease"
],
"offsets": [
[
1179,
1192
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d36.s9.e1"
}
]
},
{
"id": "1858",
"type": "Non-Specific_miRNAs",
"text": [
"miRNA"
],
"offsets": [
[
1127,
1132
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d36.s9.e2"
}
]
},
{
"id": "1859",
"type": "Relation_Trigger",
"text": [
"Upregulation"
],
"offsets": [
[
1111,
1123
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d36.s9.e3"
}
]
},
{
"id": "1860",
"type": "Specific_miRNAs",
"text": [
"hsa-miR-342-3p"
],
"offsets": [
[
1308,
1322
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d36.s10.e0"
}
]
},
{
"id": "1861",
"type": "Non-Specific_miRNAs",
"text": [
"miRNA"
],
"offsets": [
[
1244,
1249
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],
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"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d36.s10.e1"
}
]
},
{
"id": "1862",
"type": "Diseases",
"text": [
"prion disease"
],
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1365,
1378
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],
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"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d36.s10.e2"
}
]
},
{
"id": "1863",
"type": "Diseases",
"text": [
"Scrapie"
],
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1253,
1260
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d36.s10.e3"
}
]
},
{
"id": "1864",
"type": "Relation_Trigger",
"text": [
"upregulation"
],
"offsets": [
[
1292,
1304
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d36.s10.e4"
}
]
},
{
"id": "1865",
"type": "Relation_Trigger",
"text": [
"regulation"
],
"offsets": [
[
1225,
1235
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d36.s10.e5"
}
]
},
{
"id": "1866",
"type": "Diseases",
"text": [
"TSEs"
],
"offsets": [
[
1436,
1440
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d36.s10.e6"
}
]
},
{
"id": "1867",
"type": "Species",
"text": [
"human"
],
"offsets": [
[
1430,
1435
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d36.s10.e7"
}
]
},
{
"id": "1868",
"type": "Species",
"text": [
"mice"
],
"offsets": [
[
1270,
1274
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d36.s10.e8"
}
]
}
] | [] | [] | [
{
"id": "1869",
"type": "Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d36.s0.e0",
"arg2_id": "miRNA-corp.d36.s0.e2",
"normalized": []
},
{
"id": "1870",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d36.s4.e0",
"arg2_id": "miRNA-corp.d36.s4.e2",
"normalized": []
},
{
"id": "1871",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d36.s6.e0",
"arg2_id": "miRNA-corp.d36.s6.e2",
"normalized": []
},
{
"id": "1872",
"type": "Non-Specific_miRNAs-Diseases",
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"arg2_id": "miRNA-corp.d36.s6.e2",
"normalized": []
},
{
"id": "1873",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d36.s7.e2",
"arg2_id": "miRNA-corp.d36.s7.e0",
"normalized": []
},
{
"id": "1874",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d36.s7.e2",
"arg2_id": "miRNA-corp.d36.s7.e1",
"normalized": []
},
{
"id": "1875",
"type": "Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d36.s9.e0",
"arg2_id": "miRNA-corp.d36.s9.e1",
"normalized": []
},
{
"id": "1876",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d36.s9.e2",
"arg2_id": "miRNA-corp.d36.s9.e1",
"normalized": []
},
{
"id": "1877",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d36.s10.e1",
"arg2_id": "miRNA-corp.d36.s10.e2",
"normalized": []
},
{
"id": "1878",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d36.s10.e1",
"arg2_id": "miRNA-corp.d36.s10.e3",
"normalized": []
},
{
"id": "1879",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d36.s10.e1",
"arg2_id": "miRNA-corp.d36.s10.e6",
"normalized": []
},
{
"id": "1880",
"type": "Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d36.s10.e0",
"arg2_id": "miRNA-corp.d36.s10.e2",
"normalized": []
},
{
"id": "1881",
"type": "Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d36.s10.e0",
"arg2_id": "miRNA-corp.d36.s10.e3",
"normalized": []
},
{
"id": "1882",
"type": "Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d36.s10.e0",
"arg2_id": "miRNA-corp.d36.s10.e6",
"normalized": []
}
] |
1930 | miRNA-corp.d37 | [
{
"id": "1884",
"type": "title",
"text": [
"Altered microRNAs in STHdh(Q111)/Hdh(Q111) cells: miR-146a targets TBP. "
],
"offsets": [
[
0,
73
]
]
},
{
"id": "1885",
"type": "abstract",
"text": [
"We studied expression of 90 miRNAs in STHdh(Q111)/Hdh(Q111) cells, a model for Huntington's disease and compared with that obtained in STHdh(Q7)/Hdh(Q7) cells. "
],
"offsets": [
[
74,
234
]
]
},
{
"id": "1886",
"type": "abstract",
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"Fifteen miRNAs were down regulated and 12 miRNAs were up regulated more than 2-fold. "
],
"offsets": [
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235,
320
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]
},
{
"id": "1887",
"type": "abstract",
"text": [
"One hundred and forty-two genes are experimentally known targets of these altered miRNAs. "
],
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321,
411
]
]
},
{
"id": "1888",
"type": "abstract",
"text": [
"Using luciferase reporter assays with 3'-UTRs of TBP, over-expression and inhibition of miR-146a, we showed that miR-146a targets TBP. "
],
"offsets": [
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412,
547
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]
},
{
"id": "1889",
"type": "abstract",
"text": [
"It has been predicted that miR-146a may target Tata Binding Protein (TBP). "
],
"offsets": [
[
548,
623
]
]
},
{
"id": "1890",
"type": "abstract",
"text": [
"Regulation of TBP by miR-146a may contribute to HD pathogenesis. "
],
"offsets": [
[
624,
691
]
]
}
] | [
{
"id": "1891",
"type": "Specific_miRNAs",
"text": [
"miR-146a"
],
"offsets": [
[
50,
58
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d37.s0.e0"
}
]
},
{
"id": "1892",
"type": "Genes/Proteins",
"text": [
"TBP"
],
"offsets": [
[
67,
70
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],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d37.s0.e1"
}
]
},
{
"id": "1893",
"type": "Non-Specific_miRNAs",
"text": [
"microRNAs"
],
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[
8,
17
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d37.s0.e2"
}
]
},
{
"id": "1894",
"type": "Relation_Trigger",
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"targets"
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"offsets": [
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59,
66
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],
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{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d37.s0.e3"
}
]
},
{
"id": "1895",
"type": "Diseases",
"text": [
"Huntington's disease"
],
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153,
173
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],
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"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d37.s1.e0"
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]
},
{
"id": "1896",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
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102,
108
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],
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{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d37.s1.e1"
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]
},
{
"id": "1897",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
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243,
249
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{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d37.s2.e0"
}
]
},
{
"id": "1898",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
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277,
283
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],
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{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d37.s2.e1"
}
]
},
{
"id": "1899",
"type": "Relation_Trigger",
"text": [
"down regulated"
],
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[
255,
269
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d37.s2.e2"
}
]
},
{
"id": "1900",
"type": "Relation_Trigger",
"text": [
"up regulated"
],
"offsets": [
[
289,
301
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d37.s2.e3"
}
]
},
{
"id": "1901",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
[
403,
409
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d37.s4.e0"
}
]
},
{
"id": "1902",
"type": "Relation_Trigger",
"text": [
"altered miRNAs"
],
"offsets": [
[
395,
409
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d37.s4.e1"
}
]
},
{
"id": "1903",
"type": "Relation_Trigger",
"text": [
"targets"
],
"offsets": [
[
378,
385
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d37.s4.e2"
}
]
},
{
"id": "1904",
"type": "Genes/Proteins",
"text": [
"TBP"
],
"offsets": [
[
542,
545
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d37.s5.e0"
}
]
},
{
"id": "1905",
"type": "Specific_miRNAs",
"text": [
"miR-146a"
],
"offsets": [
[
500,
508
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d37.s5.e1"
}
]
},
{
"id": "1906",
"type": "Specific_miRNAs",
"text": [
"miR-146a"
],
"offsets": [
[
525,
533
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d37.s5.e2"
}
]
},
{
"id": "1907",
"type": "Genes/Proteins",
"text": [
"TBP"
],
"offsets": [
[
461,
464
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d37.s5.e3"
}
]
},
{
"id": "1908",
"type": "Relation_Trigger",
"text": [
"targets"
],
"offsets": [
[
534,
541
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d37.s5.e4"
}
]
},
{
"id": "1909",
"type": "Relation_Trigger",
"text": [
"over-expression"
],
"offsets": [
[
466,
481
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d37.s5.e5"
}
]
},
{
"id": "1910",
"type": "Relation_Trigger",
"text": [
"inhibition"
],
"offsets": [
[
486,
496
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d37.s5.e6"
}
]
},
{
"id": "1911",
"type": "Genes/Proteins",
"text": [
"Tata Binding Protein"
],
"offsets": [
[
595,
615
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d37.s6.e0"
}
]
},
{
"id": "1912",
"type": "Genes/Proteins",
"text": [
"TBP"
],
"offsets": [
[
617,
620
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d37.s6.e1"
}
]
},
{
"id": "1913",
"type": "Specific_miRNAs",
"text": [
"miR-146a"
],
"offsets": [
[
575,
583
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d37.s6.e2"
}
]
},
{
"id": "1914",
"type": "Relation_Trigger",
"text": [
"predicted that miR-146a may target"
],
"offsets": [
[
560,
594
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d37.s6.e3"
}
]
},
{
"id": "1915",
"type": "Genes/Proteins",
"text": [
"TBP"
],
"offsets": [
[
638,
641
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d37.s7.e0"
}
]
},
{
"id": "1916",
"type": "Specific_miRNAs",
"text": [
"miR-146a"
],
"offsets": [
[
645,
653
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d37.s7.e1"
}
]
},
{
"id": "1917",
"type": "Diseases",
"text": [
"HD"
],
"offsets": [
[
672,
674
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d37.s7.e2"
}
]
},
{
"id": "1918",
"type": "Relation_Trigger",
"text": [
"Regulation"
],
"offsets": [
[
624,
634
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d37.s7.e3"
}
]
}
] | [] | [] | [
{
"id": "1919",
"type": "Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d37.s0.e0",
"arg2_id": "miRNA-corp.d37.s0.e1",
"normalized": []
},
{
"id": "1920",
"type": "Non-Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d37.s0.e2",
"arg2_id": "miRNA-corp.d37.s0.e1",
"normalized": []
},
{
"id": "1921",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d37.s1.e1",
"arg2_id": "miRNA-corp.d37.s1.e0",
"normalized": []
},
{
"id": "1922",
"type": "Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d37.s5.e1",
"arg2_id": "miRNA-corp.d37.s5.e3",
"normalized": []
},
{
"id": "1923",
"type": "Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d37.s5.e1",
"arg2_id": "miRNA-corp.d37.s5.e0",
"normalized": []
},
{
"id": "1924",
"type": "Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d37.s5.e2",
"arg2_id": "miRNA-corp.d37.s5.e3",
"normalized": []
},
{
"id": "1925",
"type": "Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d37.s5.e2",
"arg2_id": "miRNA-corp.d37.s5.e0",
"normalized": []
},
{
"id": "1926",
"type": "Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d37.s6.e2",
"arg2_id": "miRNA-corp.d37.s6.e0",
"normalized": []
},
{
"id": "1927",
"type": "Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d37.s6.e2",
"arg2_id": "miRNA-corp.d37.s6.e1",
"normalized": []
},
{
"id": "1928",
"type": "Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d37.s7.e1",
"arg2_id": "miRNA-corp.d37.s7.e2",
"normalized": []
},
{
"id": "1929",
"type": "Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d37.s7.e1",
"arg2_id": "miRNA-corp.d37.s7.e0",
"normalized": []
}
] |
1949 | miRNA-corp.d38 | [
{
"id": "1931",
"type": "title",
"text": [
"This is, to our knowledge, the first case of this kind found in Argentina and is additional evidence that HAM/TSP solely related to HTLV-II infection occurs in HTLV-I-negative subjects. "
],
"offsets": [
[
0,
188
]
]
},
{
"id": "1932",
"type": "abstract",
"text": [
"A case of neurological disease featuring human T lymphocyte virus-associated myelopathy/tropical spastic paraparesis (HAM/TSP) was diagnosed by serological (Western blot) and molecular (polymerase chain reaction) criteria as related to human T lymphocyte virus (HTLV)-II infection. "
],
"offsets": [
[
189,
471
]
]
},
{
"id": "1933",
"type": "abstract",
"text": [
"A possible case of myelopathy/tropical spastic paraparesis in an Argentinian woman with human T lymphocyte virus type II. "
],
"offsets": [
[
472,
595
]
]
}
] | [
{
"id": "1934",
"type": "Diseases",
"text": [
"HAM"
],
"offsets": [
[
106,
109
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d38.s0.e0"
}
]
},
{
"id": "1935",
"type": "Diseases",
"text": [
"TSP"
],
"offsets": [
[
110,
113
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d38.s0.e1"
}
]
},
{
"id": "1936",
"type": "Diseases",
"text": [
"HTLV-II infection"
],
"offsets": [
[
132,
149
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d38.s0.e2"
}
]
},
{
"id": "1937",
"type": "Species",
"text": [
"human"
],
"offsets": [
[
425,
430
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d38.s1.e0"
}
]
},
{
"id": "1938",
"type": "Diseases",
"text": [
"human T lymphocyte virus-associated myelopathy"
],
"offsets": [
[
230,
276
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d38.s1.e1"
}
]
},
{
"id": "1939",
"type": "Diseases",
"text": [
"tropical spastic paraparesis"
],
"offsets": [
[
277,
305
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d38.s1.e2"
}
]
},
{
"id": "1940",
"type": "Diseases",
"text": [
"HAM"
],
"offsets": [
[
307,
310
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d38.s1.e3"
}
]
},
{
"id": "1941",
"type": "Diseases",
"text": [
"TSP"
],
"offsets": [
[
311,
314
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d38.s1.e4"
}
]
},
{
"id": "1942",
"type": "Diseases",
"text": [
"human T lymphocyte virus (HTLV)-II infection"
],
"offsets": [
[
425,
469
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d38.s1.e5"
}
]
},
{
"id": "1943",
"type": "Diseases",
"text": [
"neurological disease"
],
"offsets": [
[
199,
219
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d38.s1.e6"
}
]
},
{
"id": "1944",
"type": "Species",
"text": [
"human"
],
"offsets": [
[
230,
235
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d38.s1.e7"
}
]
},
{
"id": "1945",
"type": "Diseases",
"text": [
"myelopathy"
],
"offsets": [
[
491,
501
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d38.s2.e0"
}
]
},
{
"id": "1946",
"type": "Diseases",
"text": [
"tropical spastic paraparesis"
],
"offsets": [
[
502,
530
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d38.s2.e1"
}
]
},
{
"id": "1947",
"type": "Species",
"text": [
"woman"
],
"offsets": [
[
549,
554
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d38.s2.e2"
}
]
},
{
"id": "1948",
"type": "Species",
"text": [
"human"
],
"offsets": [
[
560,
565
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d38.s2.e3"
}
]
}
] | [] | [] | [] |
1999 | miRNA-corp.d39 | [
{
"id": "1950",
"type": "title",
"text": [
"Knockdown of miR-21 in cultured glioblastoma cells triggers activation of caspases and leads to increased apoptotic cell death. "
],
"offsets": [
[
0,
128
]
]
},
{
"id": "1951",
"type": "abstract",
"text": [
"Our studies show markedly elevated miR-21 levels in human glioblastoma tumor tissues, early-passage glioblastoma cultures, and in six established glioblastoma cell lines (A172, U87, U373, LN229, LN428, and LN308) compared with nonneoplastic fetal and adult brain tissues and compared with cultured nonneoplastic glial cells. "
],
"offsets": [
[
129,
454
]
]
},
{
"id": "1952",
"type": "abstract",
"text": [
"Our data suggest that aberrantly expressed miR-21 may contribute to the malignant phenotype by blocking expression of critical apoptosis-related genes. "
],
"offsets": [
[
455,
609
]
]
},
{
"id": "1953",
"type": "abstract",
"text": [
"MicroRNAs (miRNAs) are small noncoding RNA molecules that regulate protein expression by targeting the mRNA of protein-coding genes for either cleavage or repression of translation. "
],
"offsets": [
[
610,
792
]
]
},
{
"id": "1954",
"type": "abstract",
"text": [
"MicroRNA-21 is an antiapoptotic factor in human glioblastoma cells. "
],
"offsets": [
[
793,
862
]
]
},
{
"id": "1955",
"type": "abstract",
"text": [
"Here we show that the highly malignant human brain tumor, glioblastoma, strongly over-expresses a specific miRNA, miR-21. "
],
"offsets": [
[
863,
985
]
]
},
{
"id": "1956",
"type": "abstract",
"text": [
"The roles of miRNAs in lineage determination and proliferation as well as the location of several miRNA genes at sites of translocation breakpoints or deletions has led to the speculation that miRNAs could be important factors in the development or maintenance of the neoplastic state. "
],
"offsets": [
[
986,
1272
]
]
}
] | [
{
"id": "1957",
"type": "Specific_miRNAs",
"text": [
"miR-21"
],
"offsets": [
[
13,
19
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d39.s0.e0"
}
]
},
{
"id": "1958",
"type": "Relation_Trigger",
"text": [
"triggers activation"
],
"offsets": [
[
51,
70
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d39.s0.e1"
}
]
},
{
"id": "1959",
"type": "Diseases",
"text": [
"glioblastoma"
],
"offsets": [
[
32,
44
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d39.s0.e2"
}
]
},
{
"id": "1960",
"type": "Specific_miRNAs",
"text": [
"miR-21"
],
"offsets": [
[
164,
170
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d39.s1.e0"
}
]
},
{
"id": "1961",
"type": "Relation_Trigger",
"text": [
"elevated miR-21 levels"
],
"offsets": [
[
155,
177
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d39.s1.e1"
}
]
},
{
"id": "1962",
"type": "Diseases",
"text": [
"early-passage glioblastoma"
],
"offsets": [
[
215,
241
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d39.s1.e2"
}
]
},
{
"id": "1963",
"type": "Diseases",
"text": [
"human glioblastoma tumor"
],
"offsets": [
[
181,
205
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d39.s1.e3"
}
]
},
{
"id": "1964",
"type": "Diseases",
"text": [
"glioblastoma"
],
"offsets": [
[
275,
287
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d39.s1.e4"
}
]
},
{
"id": "1965",
"type": "Species",
"text": [
"human"
],
"offsets": [
[
181,
186
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d39.s1.e5"
}
]
},
{
"id": "1966",
"type": "Specific_miRNAs",
"text": [
"miR-21"
],
"offsets": [
[
498,
504
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d39.s2.e0"
}
]
},
{
"id": "1967",
"type": "Relation_Trigger",
"text": [
"aberrantly expressed"
],
"offsets": [
[
477,
497
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d39.s2.e1"
}
]
},
{
"id": "1968",
"type": "Relation_Trigger",
"text": [
"blocking expression"
],
"offsets": [
[
550,
569
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d39.s2.e2"
}
]
},
{
"id": "1969",
"type": "Non-Specific_miRNAs",
"text": [
"MicroRNAs"
],
"offsets": [
[
610,
619
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d39.s3.e0"
}
]
},
{
"id": "1970",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
[
621,
627
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d39.s3.e1"
}
]
},
{
"id": "1971",
"type": "Relation_Trigger",
"text": [
"repression of translation"
],
"offsets": [
[
765,
790
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d39.s3.e2"
}
]
},
{
"id": "1972",
"type": "Relation_Trigger",
"text": [
"regulate protein expression"
],
"offsets": [
[
668,
695
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d39.s3.e3"
}
]
},
{
"id": "1973",
"type": "Relation_Trigger",
"text": [
"targeting"
],
"offsets": [
[
699,
708
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d39.s3.e4"
}
]
},
{
"id": "1974",
"type": "Specific_miRNAs",
"text": [
"MicroRNA-21"
],
"offsets": [
[
793,
804
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d39.s4.e0"
}
]
},
{
"id": "1975",
"type": "Relation_Trigger",
"text": [
"antiapoptotic factor"
],
"offsets": [
[
811,
831
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d39.s4.e1"
}
]
},
{
"id": "1976",
"type": "Diseases",
"text": [
"glioblastoma"
],
"offsets": [
[
841,
853
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d39.s4.e2"
}
]
},
{
"id": "1977",
"type": "Species",
"text": [
"human"
],
"offsets": [
[
835,
840
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d39.s4.e3"
}
]
},
{
"id": "1978",
"type": "Specific_miRNAs",
"text": [
"miR-21"
],
"offsets": [
[
977,
983
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d39.s5.e0"
}
]
},
{
"id": "1979",
"type": "Diseases",
"text": [
"glioblastoma"
],
"offsets": [
[
921,
933
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d39.s5.e1"
}
]
},
{
"id": "1980",
"type": "Non-Specific_miRNAs",
"text": [
"miRNA"
],
"offsets": [
[
970,
975
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d39.s5.e2"
}
]
},
{
"id": "1981",
"type": "Relation_Trigger",
"text": [
"over-expresses"
],
"offsets": [
[
944,
958
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d39.s5.e3"
}
]
},
{
"id": "1982",
"type": "Diseases",
"text": [
"human brain tumor"
],
"offsets": [
[
902,
919
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d39.s5.e4"
}
]
},
{
"id": "1983",
"type": "Diseases",
"text": [
"glioblastoma"
],
"offsets": [
[
921,
933
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d39.s5.e5"
}
]
},
{
"id": "1984",
"type": "Species",
"text": [
"human"
],
"offsets": [
[
902,
907
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d39.s5.e6"
}
]
},
{
"id": "1985",
"type": "Non-Specific_miRNAs",
"text": [
"miRNA"
],
"offsets": [
[
1084,
1089
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d39.s6.e0"
}
]
},
{
"id": "1986",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
[
999,
1005
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d39.s6.e1"
}
]
},
{
"id": "1987",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
[
1179,
1185
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d39.s6.e2"
}
]
}
] | [] | [] | [
{
"id": "1988",
"type": "Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d39.s0.e0",
"arg2_id": "miRNA-corp.d39.s0.e2",
"normalized": []
},
{
"id": "1989",
"type": "Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d39.s1.e0",
"arg2_id": "miRNA-corp.d39.s1.e2",
"normalized": []
},
{
"id": "1990",
"type": "Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d39.s1.e0",
"arg2_id": "miRNA-corp.d39.s1.e3",
"normalized": []
},
{
"id": "1991",
"type": "Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d39.s1.e0",
"arg2_id": "miRNA-corp.d39.s1.e4",
"normalized": []
},
{
"id": "1992",
"type": "Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d39.s4.e0",
"arg2_id": "miRNA-corp.d39.s4.e2",
"normalized": []
},
{
"id": "1993",
"type": "Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d39.s5.e0",
"arg2_id": "miRNA-corp.d39.s5.e4",
"normalized": []
},
{
"id": "1994",
"type": "Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d39.s5.e0",
"arg2_id": "miRNA-corp.d39.s5.e5",
"normalized": []
},
{
"id": "1995",
"type": "Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d39.s5.e0",
"arg2_id": "miRNA-corp.d39.s5.e1",
"normalized": []
},
{
"id": "1996",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d39.s5.e2",
"arg2_id": "miRNA-corp.d39.s5.e4",
"normalized": []
},
{
"id": "1997",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d39.s5.e2",
"arg2_id": "miRNA-corp.d39.s5.e5",
"normalized": []
},
{
"id": "1998",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d39.s5.e2",
"arg2_id": "miRNA-corp.d39.s5.e1",
"normalized": []
}
] |
2030 | miRNA-corp.d40 | [
{
"id": "2000",
"type": "title",
"text": [
"Key microRNAs have been identified as essential for a variety of cellular events including cell lineage determination, proliferation, apoptosis, DNA repair, and cytoskeletal organization; most, if not all, acting to fine-tune gene expression at the post-transcriptional level in a host of cellular signaling networks. "
],
"offsets": [
[
0,
318
]
]
},
{
"id": "2001",
"type": "abstract",
"text": [
"Their discovery has evoked great excitement in biomedical research for their promise as potential disease biomarkers and therapeutic targets. "
],
"offsets": [
[
319,
461
]
]
},
{
"id": "2002",
"type": "abstract",
"text": [
"MicroRNAs are one of the major noncoding RNAs that function as negative regulators to silence or suppress gene expression via translational inhibition or message degradation. "
],
"offsets": [
[
462,
637
]
]
},
{
"id": "2003",
"type": "abstract",
"text": [
"Unlike the familial forms of AD, the genetic and environmental risks factors identified for sporadic AD are extensive. "
],
"offsets": [
[
638,
757
]
]
},
{
"id": "2004",
"type": "abstract",
"text": [
"Understanding complex diseases such as sporadic Alzheimer disease (AD) has been a major challenge. "
],
"offsets": [
[
758,
857
]
]
},
{
"id": "2005",
"type": "abstract",
"text": [
"MicroRNA: Implications for Alzheimer Disease and other Human CNS Disorders. "
],
"offsets": [
[
858,
935
]
]
},
{
"id": "2006",
"type": "abstract",
"text": [
"Here, the current understanding of the role of miRNAs in the central nervous system is reviewed with emphasis on their impact on the etiopathogenesis of sporadic AD. "
],
"offsets": [
[
936,
1104
]
]
},
{
"id": "2007",
"type": "abstract",
"text": [
"Dysfunctional microRNA-mediated regulation has been implicated in the pathogenesis of many disease states. "
],
"offsets": [
[
1105,
1212
]
]
}
] | [
{
"id": "2008",
"type": "Non-Specific_miRNAs",
"text": [
"microRNAs"
],
"offsets": [
[
4,
13
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d40.s0.e0"
}
]
},
{
"id": "2009",
"type": "Relation_Trigger",
"text": [
"therapeutic targets"
],
"offsets": [
[
440,
459
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d40.s1.e0"
}
]
},
{
"id": "2010",
"type": "Non-Specific_miRNAs",
"text": [
"MicroRNAs"
],
"offsets": [
[
462,
471
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d40.s2.e0"
}
]
},
{
"id": "2011",
"type": "Relation_Trigger",
"text": [
"suppress gene expression"
],
"offsets": [
[
559,
583
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d40.s2.e1"
}
]
},
{
"id": "2012",
"type": "Relation_Trigger",
"text": [
"translational inhibition"
],
"offsets": [
[
588,
612
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d40.s2.e2"
}
]
},
{
"id": "2013",
"type": "Relation_Trigger",
"text": [
"negative regulators"
],
"offsets": [
[
525,
544
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d40.s2.e3"
}
]
},
{
"id": "2014",
"type": "Diseases",
"text": [
"AD"
],
"offsets": [
[
667,
669
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d40.s3.e0"
}
]
},
{
"id": "2015",
"type": "Diseases",
"text": [
"AD"
],
"offsets": [
[
739,
741
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d40.s3.e1"
}
]
},
{
"id": "2016",
"type": "Diseases",
"text": [
"Alzheimer disease"
],
"offsets": [
[
806,
823
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d40.s4.e0"
}
]
},
{
"id": "2017",
"type": "Diseases",
"text": [
"AD"
],
"offsets": [
[
825,
827
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d40.s4.e1"
}
]
},
{
"id": "2018",
"type": "Non-Specific_miRNAs",
"text": [
"MicroRNA"
],
"offsets": [
[
858,
866
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d40.s5.e0"
}
]
},
{
"id": "2019",
"type": "Diseases",
"text": [
"Alzheimer Disease"
],
"offsets": [
[
885,
902
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d40.s5.e1"
}
]
},
{
"id": "2020",
"type": "Diseases",
"text": [
"CNS Disorders"
],
"offsets": [
[
919,
932
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d40.s5.e2"
}
]
},
{
"id": "2021",
"type": "Species",
"text": [
"Human"
],
"offsets": [
[
913,
918
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d40.s5.e3"
}
]
},
{
"id": "2022",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
[
983,
989
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d40.s6.e0"
}
]
},
{
"id": "2023",
"type": "Diseases",
"text": [
"sporadic AD"
],
"offsets": [
[
1089,
1100
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d40.s6.e1"
}
]
},
{
"id": "2024",
"type": "Non-Specific_miRNAs",
"text": [
"microRNA"
],
"offsets": [
[
1119,
1127
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d40.s7.e0"
}
]
},
{
"id": "2025",
"type": "Relation_Trigger",
"text": [
"regulation"
],
"offsets": [
[
1137,
1147
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d40.s7.e1"
}
]
},
{
"id": "2026",
"type": "Relation_Trigger",
"text": [
"Dysfunctional"
],
"offsets": [
[
1105,
1118
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d40.s7.e2"
}
]
}
] | [] | [] | [
{
"id": "2027",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d40.s5.e0",
"arg2_id": "miRNA-corp.d40.s5.e2",
"normalized": []
},
{
"id": "2028",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d40.s5.e0",
"arg2_id": "miRNA-corp.d40.s5.e1",
"normalized": []
},
{
"id": "2029",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d40.s6.e0",
"arg2_id": "miRNA-corp.d40.s6.e1",
"normalized": []
}
] |
2067 | miRNA-corp.d41 | [
{
"id": "2031",
"type": "title",
"text": [
"MicroRNAs (miRNAs) in neurodegenerative diseases. "
],
"offsets": [
[
0,
51
]
]
},
{
"id": "2032",
"type": "abstract",
"text": [
"Prior studies have shown that RNAs are pathologically altered during the inexorable course of some NDs. "
],
"offsets": [
[
52,
156
]
]
},
{
"id": "2033",
"type": "abstract",
"text": [
"Aging-related neurodegenerative diseases (NDs) are the culmination of many different genetic and environmental influences. "
],
"offsets": [
[
157,
280
]
]
},
{
"id": "2034",
"type": "abstract",
"text": [
"miRNAs are brain-enriched, small ( approximately 22 nucleotides) non-coding RNAs that participate in mRNA translational regulation. "
],
"offsets": [
[
281,
413
]
]
},
{
"id": "2035",
"type": "abstract",
"text": [
"Recent evidence suggests that microRNAs (miRNAs) may be a contributing factor in neurodegeneration. "
],
"offsets": [
[
414,
514
]
]
},
{
"id": "2036",
"type": "abstract",
"text": [
"Research about miRNAs in the context of neurodegeneration is accumulating rapidly, and the goal of this review is to provide perspective for these new data that may be helpful to specialists in either field. "
],
"offsets": [
[
515,
723
]
]
},
{
"id": "2037",
"type": "abstract",
"text": [
"Although discovered in the framework of worm development, miRNAs are now appreciated to play a dynamic role in many mammalian brain-related biochemical pathways, including neuroplasticity and stress responses. "
],
"offsets": [
[
724,
934
]
]
},
{
"id": "2038",
"type": "abstract",
"text": [
"Recently published studies pertaining to the roles of miRNAs in NDs--including Alzheimer's disease, Parkinson's disease and triplet repeat disorders-are described. "
],
"offsets": [
[
935,
1099
]
]
},
{
"id": "2039",
"type": "abstract",
"text": [
"An overview is provided about the normal functions for miRNAs, including some of the newer concepts related to the human brain. "
],
"offsets": [
[
1100,
1228
]
]
},
{
"id": "2040",
"type": "abstract",
"text": [
"Finally, a discussion is included with theoretical syntheses and possible future directions in exploring the nexus between miRNA and ND research. "
],
"offsets": [
[
1229,
1377
]
]
}
] | [
{
"id": "2041",
"type": "Non-Specific_miRNAs",
"text": [
"MicroRNAs"
],
"offsets": [
[
0,
9
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d41.s0.e0"
}
]
},
{
"id": "2042",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
[
11,
17
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d41.s0.e1"
}
]
},
{
"id": "2043",
"type": "Diseases",
"text": [
"neurodegenerative diseases"
],
"offsets": [
[
22,
48
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d41.s0.e2"
}
]
},
{
"id": "2044",
"type": "Diseases",
"text": [
"NDs"
],
"offsets": [
[
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"id": "2058",
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"id": "2059",
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"id": "2060",
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] | [] | [] | [
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}
] |
2109 | miRNA-corp.d42 | [
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{
"id": "2070",
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260,
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"id": "2071",
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499,
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"id": "2072",
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"id": "2073",
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{
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"id": "2097",
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"id": "2098",
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1596,
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1603,
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}
] | [] | [] | [
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"normalized": []
}
] |
2169 | miRNA-corp.d43 | [
{
"id": "2110",
"type": "title",
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0,
183
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]
},
{
"id": "2111",
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184,
296
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},
{
"id": "2112",
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],
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297,
501
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{
"id": "2113",
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502,
564
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{
"id": "2114",
"type": "abstract",
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],
"offsets": [
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565,
781
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{
"id": "2115",
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],
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782,
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},
{
"id": "2116",
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],
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869,
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},
{
"id": "2117",
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1058,
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{
"id": "2118",
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],
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1254,
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"id": "2120",
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"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d43.s0.e3"
}
]
},
{
"id": "2123",
"type": "Species",
"text": [
"human"
],
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30,
35
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{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d43.s0.e4"
}
]
},
{
"id": "2124",
"type": "Non-Specific_miRNAs",
"text": [
"MiRNA"
],
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184,
189
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{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d43.s1.e0"
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]
},
{
"id": "2125",
"type": "Non-Specific_miRNAs",
"text": [
"miRNA"
],
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347,
352
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{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d43.s2.e0"
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]
},
{
"id": "2126",
"type": "Non-Specific_miRNAs",
"text": [
"miRNA"
],
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366,
371
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"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d43.s2.e1"
}
]
},
{
"id": "2127",
"type": "Diseases",
"text": [
"brain tumors"
],
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485,
497
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d43.s2.e2"
}
]
},
{
"id": "2128",
"type": "Relation_Trigger",
"text": [
"tumor suppressors"
],
"offsets": [
[
464,
481
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d43.s2.e3"
}
]
},
{
"id": "2129",
"type": "Non-Specific_miRNAs",
"text": [
"MicroRNA"
],
"offsets": [
[
502,
510
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],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d43.s3.e0"
}
]
},
{
"id": "2130",
"type": "Diseases",
"text": [
"brain tumors"
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[
526,
538
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{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d43.s3.e1"
}
]
},
{
"id": "2131",
"type": "Non-Specific_miRNAs",
"text": [
"MicroRNAs"
],
"offsets": [
[
565,
574
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d43.s4.e0"
}
]
},
{
"id": "2132",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
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[
576,
582
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],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d43.s4.e1"
}
]
},
{
"id": "2133",
"type": "Relation_Trigger",
"text": [
"regulators of gene expression"
],
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[
660,
689
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],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d43.s4.e2"
}
]
},
{
"id": "2134",
"type": "Relation_Trigger",
"text": [
"tumor suppressive"
],
"offsets": [
[
752,
769
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],
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{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d43.s4.e3"
}
]
},
{
"id": "2135",
"type": "Diseases",
"text": [
"tumors"
],
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[
725,
731
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"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d43.s4.e4"
}
]
},
{
"id": "2136",
"type": "Species",
"text": [
"human"
],
"offsets": [
[
719,
724
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d43.s4.e5"
}
]
},
{
"id": "2137",
"type": "Non-Specific_miRNAs",
"text": [
"miRNA"
],
"offsets": [
[
792,
797
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d43.s5.e0"
}
]
},
{
"id": "2138",
"type": "Diseases",
"text": [
"brain cancer"
],
"offsets": [
[
836,
848
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d43.s5.e1"
}
]
},
{
"id": "2139",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
[
919,
925
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d43.s6.e0"
}
]
},
{
"id": "2140",
"type": "Non-Specific_miRNAs",
"text": [
"miRNA"
],
"offsets": [
[
1008,
1013
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d43.s6.e1"
}
]
},
{
"id": "2141",
"type": "Relation_Trigger",
"text": [
"Aberrant gene expression"
],
"offsets": [
[
869,
893
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d43.s6.e2"
}
]
},
{
"id": "2142",
"type": "Relation_Trigger",
"text": [
"abnormal expression levels"
],
"offsets": [
[
954,
980
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d43.s6.e3"
}
]
},
{
"id": "2143",
"type": "Relation_Trigger",
"text": [
"dysfunction"
],
"offsets": [
[
926,
937
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d43.s6.e4"
}
]
},
{
"id": "2144",
"type": "Diseases",
"text": [
"cancer"
],
"offsets": [
[
941,
947
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d43.s6.e5"
}
]
},
{
"id": "2145",
"type": "Diseases",
"text": [
"tumor"
],
"offsets": [
[
1028,
1033
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],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d43.s6.e6"
}
]
},
{
"id": "2146",
"type": "Non-Specific_miRNAs",
"text": [
"MiRNA"
],
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[
1058,
1063
]
],
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{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d43.s7.e0"
}
]
},
{
"id": "2147",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
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[
1160,
1166
]
],
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{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d43.s7.e1"
}
]
},
{
"id": "2148",
"type": "Relation_Trigger",
"text": [
"targeted"
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[
1148,
1156
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"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d43.s7.e2"
}
]
},
{
"id": "2149",
"type": "Diseases",
"text": [
"cancer"
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"offsets": [
[
1199,
1205
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"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d43.s7.e3"
}
]
},
{
"id": "2150",
"type": "Non-Specific_miRNAs",
"text": [
"miRNA"
],
"offsets": [
[
1283,
1288
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d43.s8.e0"
}
]
},
{
"id": "2151",
"type": "Diseases",
"text": [
"tumor"
],
"offsets": [
[
1320,
1325
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d43.s8.e1"
}
]
},
{
"id": "2152",
"type": "Diseases",
"text": [
"cancer"
],
"offsets": [
[
1398,
1404
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d43.s8.e2"
}
]
}
] | [] | [] | [
{
"id": "2153",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d43.s0.e0",
"arg2_id": "miRNA-corp.d43.s0.e1",
"normalized": []
},
{
"id": "2154",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d43.s0.e0",
"arg2_id": "miRNA-corp.d43.s0.e2",
"normalized": []
},
{
"id": "2155",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d43.s2.e0",
"arg2_id": "miRNA-corp.d43.s2.e2",
"normalized": []
},
{
"id": "2156",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d43.s2.e1",
"arg2_id": "miRNA-corp.d43.s2.e2",
"normalized": []
},
{
"id": "2157",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d43.s3.e0",
"arg2_id": "miRNA-corp.d43.s3.e1",
"normalized": []
},
{
"id": "2158",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d43.s4.e0",
"arg2_id": "miRNA-corp.d43.s4.e4",
"normalized": []
},
{
"id": "2159",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d43.s4.e1",
"arg2_id": "miRNA-corp.d43.s4.e4",
"normalized": []
},
{
"id": "2160",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d43.s5.e0",
"arg2_id": "miRNA-corp.d43.s5.e1",
"normalized": []
},
{
"id": "2161",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d43.s6.e0",
"arg2_id": "miRNA-corp.d43.s6.e5",
"normalized": []
},
{
"id": "2162",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d43.s6.e0",
"arg2_id": "miRNA-corp.d43.s6.e6",
"normalized": []
},
{
"id": "2163",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d43.s6.e1",
"arg2_id": "miRNA-corp.d43.s6.e5",
"normalized": []
},
{
"id": "2164",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d43.s6.e1",
"arg2_id": "miRNA-corp.d43.s6.e6",
"normalized": []
},
{
"id": "2165",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d43.s7.e0",
"arg2_id": "miRNA-corp.d43.s7.e3",
"normalized": []
},
{
"id": "2166",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d43.s7.e1",
"arg2_id": "miRNA-corp.d43.s7.e3",
"normalized": []
},
{
"id": "2167",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d43.s8.e0",
"arg2_id": "miRNA-corp.d43.s8.e1",
"normalized": []
},
{
"id": "2168",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d43.s8.e0",
"arg2_id": "miRNA-corp.d43.s8.e2",
"normalized": []
}
] |
2212 | miRNA-corp.d44 | [
{
"id": "2170",
"type": "title",
"text": [
"RESULTS: We detected a total of 360 miRNAs. "
],
"offsets": [
[
0,
44
]
]
},
{
"id": "2171",
"type": "abstract",
"text": [
"Selective miRNAs then were synthesized and transfected into Neuro-2a cells before oxygen-glucose deprivation. "
],
"offsets": [
[
45,
155
]
]
},
{
"id": "2172",
"type": "abstract",
"text": [
"Transfections of some of these were neuroprotective in in vitro ischemia. "
],
"offsets": [
[
156,
230
]
]
},
{
"id": "2173",
"type": "abstract",
"text": [
"Two miRNA families, miR-200 and miR-182, were selectively upregulated at 3 hours after ischemic preconditioning. "
],
"offsets": [
[
231,
344
]
]
},
{
"id": "2174",
"type": "abstract",
"text": [
"Although miRNAs control a number of conditions and diseases, few neuroprotective miRNAs have been described. "
],
"offsets": [
[
345,
454
]
]
},
{
"id": "2175",
"type": "abstract",
"text": [
"In this study, we investigated neuroprotective miRNAs induced early in ischemic preconditioning. "
],
"offsets": [
[
455,
552
]
]
},
{
"id": "2176",
"type": "abstract",
"text": [
"METHODS: Ischemic preconditioning or focal cerebral ischemia was induced in mice by transient occlusion of the middle cerebral artery for 15 or 120 minutes. "
],
"offsets": [
[
553,
710
]
]
},
{
"id": "2177",
"type": "abstract",
"text": [
"We prepared RNA samples from the ischemic cortex at 3 or 24 hours after the onset of ischemia. "
],
"offsets": [
[
711,
806
]
]
},
{
"id": "2178",
"type": "abstract",
"text": [
"MicroRNAs induced during ischemic preconditioning. "
],
"offsets": [
[
807,
859
]
]
},
{
"id": "2179",
"type": "abstract",
"text": [
"BACKGROUND AND PURPOSE: MicroRNAs (miRNA) are single-stranded short RNA molecules that regulate gene expression by either degradation or translational repression of mRNA. "
],
"offsets": [
[
860,
1031
]
]
},
{
"id": "2180",
"type": "abstract",
"text": [
"Among them, miR-200b, miR-200c, and miR-429 targeted prolyl hydroxylase 2 and had the best neuroprotective effect. "
],
"offsets": [
[
1032,
1147
]
]
},
{
"id": "2181",
"type": "abstract",
"text": [
"CONCLUSIONS: Two miRNA families, miR-200 and miR-182, were upregulated early after ischemic preconditioning and the miR-200 family was neuroprotective mainly by downregulating prolyl hydroxylase 2 levels. "
],
"offsets": [
[
1148,
1353
]
]
},
{
"id": "2182",
"type": "abstract",
"text": [
"These miRNAs may be useful in future research and therapeutic applications. "
],
"offsets": [
[
1354,
1432
]
]
}
] | [
{
"id": "2183",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
[
36,
42
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d44.s0.e0"
}
]
},
{
"id": "2184",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
[
55,
61
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d44.s1.e0"
}
]
},
{
"id": "2185",
"type": "Diseases",
"text": [
"ischemia"
],
"offsets": [
[
220,
228
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d44.s2.e0"
}
]
},
{
"id": "2186",
"type": "Non-Specific_miRNAs",
"text": [
"miRNA"
],
"offsets": [
[
235,
240
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d44.s3.e0"
}
]
},
{
"id": "2187",
"type": "Specific_miRNAs",
"text": [
"miR-200"
],
"offsets": [
[
251,
258
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d44.s3.e1"
}
]
},
{
"id": "2188",
"type": "Specific_miRNAs",
"text": [
"miR-182"
],
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[
263,
270
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d44.s3.e2"
}
]
},
{
"id": "2189",
"type": "Relation_Trigger",
"text": [
"upregulated"
],
"offsets": [
[
289,
300
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d44.s3.e3"
}
]
},
{
"id": "2190",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
[
426,
432
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d44.s4.e0"
}
]
},
{
"id": "2191",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
[
354,
360
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d44.s4.e1"
}
]
},
{
"id": "2192",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
[
502,
508
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d44.s5.e0"
}
]
},
{
"id": "2193",
"type": "Diseases",
"text": [
"focal cerebral ischemia"
],
"offsets": [
[
590,
613
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d44.s6.e0"
}
]
},
{
"id": "2194",
"type": "Species",
"text": [
"mice"
],
"offsets": [
[
629,
633
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d44.s6.e1"
}
]
},
{
"id": "2195",
"type": "Diseases",
"text": [
"ischemia"
],
"offsets": [
[
796,
804
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d44.s7.e0"
}
]
},
{
"id": "2196",
"type": "Non-Specific_miRNAs",
"text": [
"MicroRNAs"
],
"offsets": [
[
807,
816
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d44.s8.e0"
}
]
},
{
"id": "2197",
"type": "Relation_Trigger",
"text": [
"translational repression"
],
"offsets": [
[
997,
1021
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d44.s9.e0"
}
]
},
{
"id": "2198",
"type": "Non-Specific_miRNAs",
"text": [
"MicroRNAs"
],
"offsets": [
[
884,
893
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d44.s9.e1"
}
]
},
{
"id": "2199",
"type": "Non-Specific_miRNAs",
"text": [
"miRNA"
],
"offsets": [
[
895,
900
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d44.s9.e2"
}
]
},
{
"id": "2200",
"type": "Relation_Trigger",
"text": [
"regulate gene expression"
],
"offsets": [
[
947,
971
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d44.s9.e3"
}
]
},
{
"id": "2201",
"type": "Specific_miRNAs",
"text": [
"miR-200b"
],
"offsets": [
[
1044,
1052
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d44.s10.e0"
}
]
},
{
"id": "2202",
"type": "Specific_miRNAs",
"text": [
"miR-200c"
],
"offsets": [
[
1054,
1062
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d44.s10.e1"
}
]
},
{
"id": "2203",
"type": "Specific_miRNAs",
"text": [
"miR-429"
],
"offsets": [
[
1068,
1075
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d44.s10.e2"
}
]
},
{
"id": "2204",
"type": "Relation_Trigger",
"text": [
"targeted"
],
"offsets": [
[
1076,
1084
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d44.s10.e3"
}
]
},
{
"id": "2205",
"type": "Non-Specific_miRNAs",
"text": [
"miRNA"
],
"offsets": [
[
1165,
1170
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d44.s11.e0"
}
]
},
{
"id": "2206",
"type": "Specific_miRNAs",
"text": [
"miR-200"
],
"offsets": [
[
1181,
1188
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d44.s11.e1"
}
]
},
{
"id": "2207",
"type": "Specific_miRNAs",
"text": [
"miR-182"
],
"offsets": [
[
1193,
1200
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d44.s11.e2"
}
]
},
{
"id": "2208",
"type": "Relation_Trigger",
"text": [
"upregulated"
],
"offsets": [
[
1207,
1218
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d44.s11.e3"
}
]
},
{
"id": "2209",
"type": "Relation_Trigger",
"text": [
"downregulating"
],
"offsets": [
[
1309,
1323
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d44.s11.e4"
}
]
},
{
"id": "2210",
"type": "Specific_miRNAs",
"text": [
"miR-200"
],
"offsets": [
[
1264,
1271
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d44.s11.e5"
}
]
},
{
"id": "2211",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
[
1360,
1366
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d44.s12.e0"
}
]
}
] | [] | [] | [] |
2239 | miRNA-corp.d45 | [
{
"id": "2213",
"type": "title",
"text": [
"A significant association with death was found for major adverse events, medical adverse events, and nosocomial infections, with adjusted odds ratio estimates of 3.74 [95% confidence interval (CI) 1.64-8.54], 3.71 (95% CI 1.61-8.53), and 3.22 (95% CI 1.21-8.59), respectively. "
],
"offsets": [
[
0,
277
]
]
},
{
"id": "2214",
"type": "abstract",
"text": [
"CONCLUSION: Adverse events, mostly severe, predominated among deceased patients, resulting mainly from diagnostic or therapeutic procedures and nursing activities. "
],
"offsets": [
[
278,
442
]
]
},
{
"id": "2215",
"type": "abstract",
"text": [
"In spite of limitations concerning the observational retrospective nature of this study, we found that severe adverse events, medical adverse events, and nosocomial infections were significantly associated with death in stroke patients. "
],
"offsets": [
[
443,
682
]
]
},
{
"id": "2216",
"type": "abstract",
"text": [
"OBJECTIVES: To identify the occurrence of adverse events in stroke patients presenting to the emergency department of a tertiary university facility, and to disclose the categories of adverse events associated with death. "
],
"offsets": [
[
683,
905
]
]
},
{
"id": "2217",
"type": "abstract",
"text": [
"Adverse events and death in stroke patients admitted to the emergency department of a tertiary university hospital. "
],
"offsets": [
[
906,
1023
]
]
},
{
"id": "2218",
"type": "abstract",
"text": [
"RESULTS: Adverse events totaled 1218 and occurred in 295 patients: 932 events (76.5%) in 170 cases and 286 (23.5%) in 125 controls. "
],
"offsets": [
[
1024,
1156
]
]
},
{
"id": "2219",
"type": "abstract",
"text": [
"The cases comprised 234 consecutive deaths and the controls 234 discharged patients, matched for primary diagnosis and admission period. "
],
"offsets": [
[
1157,
1294
]
]
},
{
"id": "2220",
"type": "abstract",
"text": [
"METHODS: This matched case-control study enrolled 468 patients admitted with stroke to the emergency department from March 1996 to September 1999. "
],
"offsets": [
[
1295,
1442
]
]
},
{
"id": "2221",
"type": "abstract",
"text": [
"The association with death was analysed by conditional logistic regression. "
],
"offsets": [
[
1443,
1519
]
]
}
] | [
{
"id": "2222",
"type": "Diseases",
"text": [
"nosocomial infections"
],
"offsets": [
[
101,
122
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d45.s0.e0"
}
]
},
{
"id": "2223",
"type": "Relation_Trigger",
"text": [
"association"
],
"offsets": [
[
14,
25
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d45.s0.e1"
}
]
},
{
"id": "2224",
"type": "Species",
"text": [
"patients"
],
"offsets": [
[
349,
357
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d45.s1.e0"
}
]
},
{
"id": "2225",
"type": "Species",
"text": [
"patients"
],
"offsets": [
[
670,
678
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d45.s2.e0"
}
]
},
{
"id": "2226",
"type": "Diseases",
"text": [
"nosocomial infections"
],
"offsets": [
[
597,
618
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d45.s2.e1"
}
]
},
{
"id": "2227",
"type": "Diseases",
"text": [
"stroke"
],
"offsets": [
[
663,
669
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d45.s2.e2"
}
]
},
{
"id": "2228",
"type": "Relation_Trigger",
"text": [
"associated"
],
"offsets": [
[
638,
648
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d45.s2.e3"
}
]
},
{
"id": "2229",
"type": "Species",
"text": [
"patients"
],
"offsets": [
[
750,
758
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d45.s3.e0"
}
]
},
{
"id": "2230",
"type": "Diseases",
"text": [
"stroke"
],
"offsets": [
[
743,
749
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d45.s3.e1"
}
]
},
{
"id": "2231",
"type": "Relation_Trigger",
"text": [
"associated"
],
"offsets": [
[
882,
892
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d45.s3.e2"
}
]
},
{
"id": "2232",
"type": "Species",
"text": [
"patients"
],
"offsets": [
[
941,
949
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d45.s4.e0"
}
]
},
{
"id": "2233",
"type": "Diseases",
"text": [
"stroke"
],
"offsets": [
[
934,
940
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d45.s4.e1"
}
]
},
{
"id": "2234",
"type": "Species",
"text": [
"patients"
],
"offsets": [
[
1081,
1089
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d45.s6.e0"
}
]
},
{
"id": "2235",
"type": "Species",
"text": [
"patients"
],
"offsets": [
[
1232,
1240
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d45.s9.e0"
}
]
},
{
"id": "2236",
"type": "Species",
"text": [
"patients"
],
"offsets": [
[
1349,
1357
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d45.s10.e0"
}
]
},
{
"id": "2237",
"type": "Diseases",
"text": [
"stroke"
],
"offsets": [
[
1372,
1378
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d45.s10.e1"
}
]
},
{
"id": "2238",
"type": "Relation_Trigger",
"text": [
"association"
],
"offsets": [
[
1447,
1458
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d45.s11.e0"
}
]
}
] | [] | [] | [] |
2282 | miRNA-corp.d46 | [
{
"id": "2240",
"type": "title",
"text": [
"These findings reveal a novel mechanism of targeted intercellular protein regulation between brain tumor cells. "
],
"offsets": [
[
0,
114
]
]
},
{
"id": "2241",
"type": "abstract",
"text": [
"Here, we transformed rat 9L gliosarcoma cells to express cel-miR-67, a miRNA that lacks homology in rat. "
],
"offsets": [
[
115,
220
]
]
},
{
"id": "2242",
"type": "abstract",
"text": [
"Coculture of these cells with cells that expressed a luciferase reporter that contained a complementary sequence to cel-miR-67 resulted in significant suppression of luciferase expression. "
],
"offsets": [
[
221,
410
]
]
},
{
"id": "2243",
"type": "abstract",
"text": [
"Functional microRNA is transferred between glioma cells. "
],
"offsets": [
[
411,
469
]
]
},
{
"id": "2244",
"type": "abstract",
"text": [
"MicroRNAs (miRNA) are single-stranded 17- to 27-nucleotide RNA molecules that regulate gene expression by posttranscriptional silencing of target mRNAs. "
],
"offsets": [
[
470,
623
]
]
},
{
"id": "2245",
"type": "abstract",
"text": [
"Finally, in situ hybridization revealed the presence of cel-miR-67 in cel-miR-67-null 9L cells after coculture with cel-miR-67-expressing cells. "
],
"offsets": [
[
624,
769
]
]
},
{
"id": "2246",
"type": "abstract",
"text": [
"Our data show that miRNA transcribed in glioma cells can be transferred to adjacent cells and induces targeted inhibition of protein expression in the acceptor cells. "
],
"offsets": [
[
770,
937
]
]
},
{
"id": "2247",
"type": "abstract",
"text": [
"This effect was also observed in the U87-MG human glioma cell line. "
],
"offsets": [
[
938,
1006
]
]
},
{
"id": "2248",
"type": "abstract",
"text": [
"Moreover, luciferase suppression was inhibited by the addition of carbenoxolone to cocultures, suggesting that gap junction communication regulates intercellular transfer of miRNA. "
],
"offsets": [
[
1007,
1188
]
]
}
] | [
{
"id": "2249",
"type": "Diseases",
"text": [
"brain tumor"
],
"offsets": [
[
93,
104
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d46.s0.e0"
}
]
},
{
"id": "2250",
"type": "Relation_Trigger",
"text": [
"targeted"
],
"offsets": [
[
43,
51
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d46.s0.e1"
}
]
},
{
"id": "2251",
"type": "Relation_Trigger",
"text": [
"regulation"
],
"offsets": [
[
74,
84
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d46.s0.e2"
}
]
},
{
"id": "2252",
"type": "Non-Specific_miRNAs",
"text": [
"miRNA"
],
"offsets": [
[
186,
191
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d46.s1.e0"
}
]
},
{
"id": "2253",
"type": "Specific_miRNAs",
"text": [
"cel-miR-67"
],
"offsets": [
[
172,
182
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d46.s1.e1"
}
]
},
{
"id": "2254",
"type": "Diseases",
"text": [
"gliosarcoma"
],
"offsets": [
[
143,
154
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d46.s1.e2"
}
]
},
{
"id": "2255",
"type": "Species",
"text": [
"rat"
],
"offsets": [
[
215,
218
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d46.s1.e3"
}
]
},
{
"id": "2256",
"type": "Species",
"text": [
"rat"
],
"offsets": [
[
136,
139
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d46.s1.e4"
}
]
},
{
"id": "2257",
"type": "Specific_miRNAs",
"text": [
"cel-miR-67"
],
"offsets": [
[
337,
347
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d46.s2.e0"
}
]
},
{
"id": "2258",
"type": "Relation_Trigger",
"text": [
"suppression of luciferase expression"
],
"offsets": [
[
372,
408
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d46.s2.e1"
}
]
},
{
"id": "2259",
"type": "Non-Specific_miRNAs",
"text": [
"microRNA"
],
"offsets": [
[
422,
430
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d46.s3.e0"
}
]
},
{
"id": "2260",
"type": "Diseases",
"text": [
"glioma"
],
"offsets": [
[
454,
460
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d46.s3.e1"
}
]
},
{
"id": "2261",
"type": "Non-Specific_miRNAs",
"text": [
"MicroRNAs"
],
"offsets": [
[
470,
479
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d46.s4.e0"
}
]
},
{
"id": "2262",
"type": "Non-Specific_miRNAs",
"text": [
"miRNA"
],
"offsets": [
[
481,
486
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d46.s4.e1"
}
]
},
{
"id": "2263",
"type": "Relation_Trigger",
"text": [
"regulate gene expression"
],
"offsets": [
[
548,
572
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d46.s4.e2"
}
]
},
{
"id": "2264",
"type": "Relation_Trigger",
"text": [
"target"
],
"offsets": [
[
609,
615
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d46.s4.e3"
}
]
},
{
"id": "2265",
"type": "Specific_miRNAs",
"text": [
"cel-miR-67"
],
"offsets": [
[
680,
690
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d46.s5.e0"
}
]
},
{
"id": "2266",
"type": "Specific_miRNAs",
"text": [
"cel-miR-67"
],
"offsets": [
[
694,
704
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d46.s5.e1"
}
]
},
{
"id": "2267",
"type": "Specific_miRNAs",
"text": [
"cel-miR-67"
],
"offsets": [
[
740,
750
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d46.s5.e2"
}
]
},
{
"id": "2268",
"type": "Non-Specific_miRNAs",
"text": [
"miRNA"
],
"offsets": [
[
789,
794
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d46.s6.e0"
}
]
},
{
"id": "2269",
"type": "Diseases",
"text": [
"glioma"
],
"offsets": [
[
810,
816
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d46.s6.e1"
}
]
},
{
"id": "2270",
"type": "Relation_Trigger",
"text": [
"targeted"
],
"offsets": [
[
872,
880
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d46.s6.e2"
}
]
},
{
"id": "2271",
"type": "Relation_Trigger",
"text": [
"inhibition of protein expression"
],
"offsets": [
[
881,
913
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d46.s6.e3"
}
]
},
{
"id": "2272",
"type": "Diseases",
"text": [
"glioma"
],
"offsets": [
[
988,
994
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d46.s7.e0"
}
]
},
{
"id": "2273",
"type": "Species",
"text": [
"human"
],
"offsets": [
[
982,
987
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d46.s7.e1"
}
]
},
{
"id": "2274",
"type": "Non-Specific_miRNAs",
"text": [
"miRNA"
],
"offsets": [
[
1181,
1186
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d46.s8.e0"
}
]
},
{
"id": "2275",
"type": "Relation_Trigger",
"text": [
"suppression"
],
"offsets": [
[
1028,
1039
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d46.s8.e1"
}
]
},
{
"id": "2276",
"type": "Relation_Trigger",
"text": [
"inhibited"
],
"offsets": [
[
1044,
1053
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d46.s8.e2"
}
]
},
{
"id": "2277",
"type": "Relation_Trigger",
"text": [
"regulates"
],
"offsets": [
[
1145,
1154
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d46.s8.e3"
}
]
}
] | [] | [] | [
{
"id": "2278",
"type": "Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d46.s1.e1",
"arg2_id": "miRNA-corp.d46.s1.e2",
"normalized": []
},
{
"id": "2279",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d46.s1.e0",
"arg2_id": "miRNA-corp.d46.s1.e2",
"normalized": []
},
{
"id": "2280",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d46.s3.e0",
"arg2_id": "miRNA-corp.d46.s3.e1",
"normalized": []
},
{
"id": "2281",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d46.s6.e0",
"arg2_id": "miRNA-corp.d46.s6.e1",
"normalized": []
}
] |
2338 | miRNA-corp.d47 | [
{
"id": "2283",
"type": "title",
"text": [
"Moreover, bioinformatics analyses revealed a theoretical basis for many other potential interactions between natural antisense transcripts and miRNAs at the binding sites of the latter. "
],
"offsets": [
[
0,
188
]
]
},
{
"id": "2284",
"type": "abstract",
"text": [
"BACKGROUND: MicroRNAs (miRNAs) have the potential to regulate diverse sets of mRNA targets. "
],
"offsets": [
[
189,
281
]
]
},
{
"id": "2285",
"type": "abstract",
"text": [
"Evidence for natural antisense transcript-mediated inhibition of microRNA function. "
],
"offsets": [
[
282,
367
]
]
},
{
"id": "2286",
"type": "abstract",
"text": [
"Indeed, miR-485-5p and BACE1-antisense compete for binding within the same region in the open reading frame of the BACE1 mRNA. "
],
"offsets": [
[
368,
495
]
]
},
{
"id": "2287",
"type": "abstract",
"text": [
"RESULTS: We report here that BACE1-antisense prevents miRNA-induced repression of BACE1 mRNA by masking the binding site for miR-485-5p. "
],
"offsets": [
[
496,
633
]
]
},
{
"id": "2288",
"type": "abstract",
"text": [
"The BACE1-antisense transcript is markedly up-regulated in brain samples from Alzheimer's disease patients and promotes the stability of the (sense) BACE1 transcript. "
],
"offsets": [
[
634,
801
]
]
},
{
"id": "2289",
"type": "abstract",
"text": [
"We have recently identified and characterized a highly conserved non-coding antisense transcript for beta-secretase-1 (BACE1), a critical enzyme in Alzheimer's disease pathophysiology. "
],
"offsets": [
[
802,
987
]
]
},
{
"id": "2290",
"type": "abstract",
"text": [
"We observed opposing effects of BACE1-antisense and miR-485-5p on BACE1 protein in vitro and showed that Locked Nucleic Acid-antimiR mediated knockdown of miR-485-5p as well as BACE1-antisense over-expression can prevent the miRNA-induced BACE1 suppression. "
],
"offsets": [
[
988,
1246
]
]
},
{
"id": "2291",
"type": "abstract",
"text": [
"We found that the expression of BACE1-antisense as well as miR-485-5p are dysregulated in RNA samples from Alzheimer's disease subjects compared to control individuals. "
],
"offsets": [
[
1247,
1416
]
]
},
{
"id": "2292",
"type": "abstract",
"text": [
"CONCLUSIONS: Our data demonstrate an interface between two distinct groups of regulatory RNAs in the computation of BACE1 gene expression. "
],
"offsets": [
[
1417,
1556
]
]
}
] | [
{
"id": "2293",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
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[
143,
149
]
],
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{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d47.s0.e0"
}
]
},
{
"id": "2294",
"type": "Relation_Trigger",
"text": [
"binding sites"
],
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[
157,
170
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d47.s0.e1"
}
]
},
{
"id": "2295",
"type": "Non-Specific_miRNAs",
"text": [
"MicroRNAs"
],
"offsets": [
[
201,
210
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d47.s2.e0"
}
]
},
{
"id": "2296",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
[
212,
218
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d47.s2.e1"
}
]
},
{
"id": "2297",
"type": "Relation_Trigger",
"text": [
"regulate"
],
"offsets": [
[
242,
250
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d47.s2.e2"
}
]
},
{
"id": "2298",
"type": "Relation_Trigger",
"text": [
"targets"
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[
272,
279
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d47.s2.e3"
}
]
},
{
"id": "2299",
"type": "Non-Specific_miRNAs",
"text": [
"microRNA"
],
"offsets": [
[
347,
355
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d47.s3.e0"
}
]
},
{
"id": "2300",
"type": "Relation_Trigger",
"text": [
"inhibition"
],
"offsets": [
[
333,
343
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d47.s3.e1"
}
]
},
{
"id": "2301",
"type": "Specific_miRNAs",
"text": [
"miR-485-5p"
],
"offsets": [
[
376,
386
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d47.s4.e0"
}
]
},
{
"id": "2302",
"type": "Genes/Proteins",
"text": [
"BACE1"
],
"offsets": [
[
483,
488
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d47.s4.e1"
}
]
},
{
"id": "2303",
"type": "Relation_Trigger",
"text": [
"binding"
],
"offsets": [
[
419,
426
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d47.s4.e2"
}
]
},
{
"id": "2304",
"type": "Non-Specific_miRNAs",
"text": [
"miRNA"
],
"offsets": [
[
550,
555
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d47.s5.e0"
}
]
},
{
"id": "2305",
"type": "Relation_Trigger",
"text": [
"binding site"
],
"offsets": [
[
604,
616
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d47.s5.e1"
}
]
},
{
"id": "2306",
"type": "Genes/Proteins",
"text": [
"BACE1"
],
"offsets": [
[
578,
583
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d47.s5.e2"
}
]
},
{
"id": "2307",
"type": "Specific_miRNAs",
"text": [
"miR-485-5p"
],
"offsets": [
[
621,
631
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d47.s5.e3"
}
]
},
{
"id": "2308",
"type": "Relation_Trigger",
"text": [
"repression"
],
"offsets": [
[
564,
574
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d47.s5.e4"
}
]
},
{
"id": "2309",
"type": "Diseases",
"text": [
"Alzheimer's disease"
],
"offsets": [
[
712,
731
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d47.s6.e0"
}
]
},
{
"id": "2310",
"type": "Genes/Proteins",
"text": [
"BACE1"
],
"offsets": [
[
783,
788
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d47.s6.e1"
}
]
},
{
"id": "2311",
"type": "Relation_Trigger",
"text": [
"up-regulated"
],
"offsets": [
[
677,
689
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d47.s6.e2"
}
]
},
{
"id": "2312",
"type": "Species",
"text": [
"patients"
],
"offsets": [
[
732,
740
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d47.s6.e3"
}
]
},
{
"id": "2313",
"type": "Diseases",
"text": [
"Alzheimer's disease"
],
"offsets": [
[
950,
969
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d47.s7.e0"
}
]
},
{
"id": "2314",
"type": "Genes/Proteins",
"text": [
"BACE1"
],
"offsets": [
[
921,
926
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d47.s7.e1"
}
]
},
{
"id": "2315",
"type": "Genes/Proteins",
"text": [
"beta-secretase-1"
],
"offsets": [
[
903,
919
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d47.s7.e2"
}
]
},
{
"id": "2316",
"type": "Relation_Trigger",
"text": [
"suppression"
],
"offsets": [
[
1233,
1244
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d47.s8.e0"
}
]
},
{
"id": "2317",
"type": "Genes/Proteins",
"text": [
"BACE1"
],
"offsets": [
[
1227,
1232
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d47.s8.e1"
}
]
},
{
"id": "2318",
"type": "Specific_miRNAs",
"text": [
"miR-485-5p"
],
"offsets": [
[
1040,
1050
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d47.s8.e2"
}
]
},
{
"id": "2319",
"type": "Specific_miRNAs",
"text": [
"miR-485-5p"
],
"offsets": [
[
1143,
1153
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d47.s8.e3"
}
]
},
{
"id": "2320",
"type": "Relation_Trigger",
"text": [
"over-expression"
],
"offsets": [
[
1181,
1196
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d47.s8.e4"
}
]
},
{
"id": "2321",
"type": "Non-Specific_miRNAs",
"text": [
"miRNA"
],
"offsets": [
[
1213,
1218
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d47.s8.e5"
}
]
},
{
"id": "2322",
"type": "Genes/Proteins",
"text": [
"BACE1"
],
"offsets": [
[
1054,
1059
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d47.s8.e6"
}
]
},
{
"id": "2323",
"type": "Relation_Trigger",
"text": [
"dysregulated"
],
"offsets": [
[
1321,
1333
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d47.s9.e0"
}
]
},
{
"id": "2324",
"type": "Diseases",
"text": [
"Alzheimer's disease"
],
"offsets": [
[
1354,
1373
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d47.s9.e1"
}
]
},
{
"id": "2325",
"type": "Specific_miRNAs",
"text": [
"miR-485-5p"
],
"offsets": [
[
1306,
1316
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d47.s9.e2"
}
]
},
{
"id": "2326",
"type": "Genes/Proteins",
"text": [
"BACE1"
],
"offsets": [
[
1533,
1538
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d47.s10.e0"
}
]
},
{
"id": "2327",
"type": "Relation_Trigger",
"text": [
"regulatory"
],
"offsets": [
[
1495,
1505
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d47.s10.e1"
}
]
}
] | [] | [] | [
{
"id": "2328",
"type": "Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d47.s4.e0",
"arg2_id": "miRNA-corp.d47.s4.e1",
"normalized": []
},
{
"id": "2329",
"type": "Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d47.s5.e3",
"arg2_id": "miRNA-corp.d47.s5.e2",
"normalized": []
},
{
"id": "2330",
"type": "Non-Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d47.s5.e0",
"arg2_id": "miRNA-corp.d47.s5.e2",
"normalized": []
},
{
"id": "2331",
"type": "Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d47.s8.e2",
"arg2_id": "miRNA-corp.d47.s8.e1",
"normalized": []
},
{
"id": "2332",
"type": "Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d47.s8.e2",
"arg2_id": "miRNA-corp.d47.s8.e6",
"normalized": []
},
{
"id": "2333",
"type": "Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d47.s8.e3",
"arg2_id": "miRNA-corp.d47.s8.e1",
"normalized": []
},
{
"id": "2334",
"type": "Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d47.s8.e3",
"arg2_id": "miRNA-corp.d47.s8.e6",
"normalized": []
},
{
"id": "2335",
"type": "Non-Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d47.s8.e5",
"arg2_id": "miRNA-corp.d47.s8.e1",
"normalized": []
},
{
"id": "2336",
"type": "Non-Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d47.s8.e5",
"arg2_id": "miRNA-corp.d47.s8.e6",
"normalized": []
},
{
"id": "2337",
"type": "Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d47.s9.e2",
"arg2_id": "miRNA-corp.d47.s9.e1",
"normalized": []
}
] |
2387 | miRNA-corp.d48 | [
{
"id": "2339",
"type": "title",
"text": [
"The mRNA expression of the RNases Drosha and Dicer, cofactor Pasha, and the pre-miRNA transporter exportin-5, which modulate miRNA biogenesis, were not altered after transient middle cerebral artery occlusion. "
],
"offsets": [
[
0,
210
]
]
},
{
"id": "2340",
"type": "abstract",
"text": [
"Thus, the present studies indicate a critical role of miRNAs in controlling mRNA transcription and translation in the postischemic brain. "
],
"offsets": [
[
211,
351
]
]
},
{
"id": "2341",
"type": "abstract",
"text": [
"Bioinformatics analysis indicated a correlation between miRNAs altered to several mRNAs known to mediate inflammation, transcription, neuroprotection, receptors function, and ionic homeostasis. "
],
"offsets": [
[
352,
546
]
]
},
{
"id": "2342",
"type": "abstract",
"text": [
"In silico analysis showed sequence complementarity of eight miRNAs induced after focal ischemia to 877 promoters indicating the possibility of noncoding RNA-induced activation of gene expression. "
],
"offsets": [
[
547,
743
]
]
},
{
"id": "2343",
"type": "abstract",
"text": [
"Antagomir-mediated prevention of mir-145 expression led to an increased protein expression of its downstream target superoxide dismutase-2 in the postischemic brain. "
],
"offsets": [
[
744,
910
]
]
},
{
"id": "2344",
"type": "abstract",
"text": [
"MicroRNAs (miRNAs) are approximately 22 nucleotides long, noncoding RNAs that control cellular function by either degrading mRNAs or arresting their translation. "
],
"offsets": [
[
911,
1073
]
]
},
{
"id": "2345",
"type": "abstract",
"text": [
"Transient focal ischemia induces extensive temporal changes in rat cerebral microRNAome. "
],
"offsets": [
[
1074,
1164
]
]
},
{
"id": "2346",
"type": "abstract",
"text": [
"Of the 238 miRNAs evaluated, 8 showed increased and 12 showed decreased expression at least at 4 out of 5 reperfusion time points studied between 3 h and 3 days compared with sham. "
],
"offsets": [
[
1165,
1346
]
]
},
{
"id": "2347",
"type": "abstract",
"text": [
"To understand their functional significance in ischemic pathophysiology, we profiled miRNAs in adult rat brain as a function of reperfusion time after transient middle cerebral artery occlusion. "
],
"offsets": [
[
1347,
1542
]
]
}
] | [
{
"id": "2348",
"type": "Genes/Proteins",
"text": [
"Drosha"
],
"offsets": [
[
34,
40
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d48.s0.e0"
}
]
},
{
"id": "2349",
"type": "Genes/Proteins",
"text": [
"Dicer"
],
"offsets": [
[
45,
50
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d48.s0.e1"
}
]
},
{
"id": "2350",
"type": "Diseases",
"text": [
"cerebral artery occlusion"
],
"offsets": [
[
183,
208
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d48.s0.e2"
}
]
},
{
"id": "2351",
"type": "Non-Specific_miRNAs",
"text": [
"miRNA"
],
"offsets": [
[
125,
130
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d48.s0.e3"
}
]
},
{
"id": "2352",
"type": "Genes/Proteins",
"text": [
"exportin-5"
],
"offsets": [
[
98,
108
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d48.s0.e4"
}
]
},
{
"id": "2353",
"type": "Relation_Trigger",
"text": [
"modulate"
],
"offsets": [
[
116,
124
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d48.s0.e5"
}
]
},
{
"id": "2354",
"type": "Non-Specific_miRNAs",
"text": [
"miRNA"
],
"offsets": [
[
80,
85
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d48.s0.e6"
}
]
},
{
"id": "2355",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
[
265,
271
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d48.s1.e0"
}
]
},
{
"id": "2356",
"type": "Non-Specific_miRNAs",
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"miRNAs"
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408,
414
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"id": "2357",
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"correlation"
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388,
399
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"id": "2358",
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"inflammation"
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457,
469
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"id": "2359",
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607,
613
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"id": "2360",
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"focal ischemia"
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628,
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{
"id": "2361",
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"activation"
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{
"id": "2362",
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777,
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{
"id": "2363",
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860,
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{
"id": "2364",
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806,
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"target"
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853,
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"id": "2366",
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911,
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"id": "2367",
"type": "Non-Specific_miRNAs",
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922,
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"db_id": "miRNA-corp.d48.s6.e1"
}
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},
{
"id": "2368",
"type": "Diseases",
"text": [
"Transient focal ischemia"
],
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1074,
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"db_id": "miRNA-corp.d48.s7.e0"
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},
{
"id": "2369",
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1137,
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{
"id": "2370",
"type": "Non-Specific_miRNAs",
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1176,
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{
"id": "2371",
"type": "Relation_Trigger",
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1227,
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{
"id": "2372",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
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1432,
1438
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"db_id": "miRNA-corp.d48.s9.e0"
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{
"id": "2373",
"type": "Diseases",
"text": [
"middle cerebral artery occlusion"
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1508,
1540
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},
{
"id": "2374",
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"rat"
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1448,
1451
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{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d48.s9.e2"
}
]
}
] | [] | [] | [
{
"id": "2375",
"type": "Non-Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d48.s0.e3",
"arg2_id": "miRNA-corp.d48.s0.e4",
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},
{
"id": "2376",
"type": "Non-Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d48.s0.e3",
"arg2_id": "miRNA-corp.d48.s0.e0",
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},
{
"id": "2377",
"type": "Non-Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d48.s0.e3",
"arg2_id": "miRNA-corp.d48.s0.e1",
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{
"id": "2378",
"type": "Non-Specific_miRNAs-Diseases",
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},
{
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"normalized": []
}
] |
2407 | miRNA-corp.d49 | [
{
"id": "2388",
"type": "title",
"text": [
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0,
194
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"type": "abstract",
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],
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195,
302
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]
},
{
"id": "2390",
"type": "abstract",
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],
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303,
494
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]
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{
"id": "2391",
"type": "abstract",
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],
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495,
590
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},
{
"id": "2392",
"type": "abstract",
"text": [
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],
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591,
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{
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],
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871,
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]
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"id": "2395",
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282,
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293,
299
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"id": "2398",
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228,
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445,
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"id": "2400",
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"id": "2401",
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{
"id": "2402",
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{
"id": "2403",
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798,
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"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d49.s10.e0"
}
]
}
] | [] | [] | [
{
"id": "2405",
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{
"id": "2406",
"type": "Non-Specific_miRNAs-Genes/Proteins",
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"normalized": []
}
] |
2527 | miRNA-corp.d50 | [
{
"id": "2408",
"type": "title",
"text": [
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],
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[
0,
209
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]
},
{
"id": "2409",
"type": "abstract",
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],
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[
210,
322
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]
},
{
"id": "2410",
"type": "abstract",
"text": [
"Our research revealed that 136 miRNAs were expressing at 6 h post injury, in which 13 miRNAs were more than 2-fold up-regulated, and 14 miRNAs were more than 2-fold down-regulated; 118 miRNAs were expressing at 24 h post injury, in which 4 miRNAs were more than 2-fold up-regulated, and 23 miRNAs were more than 2-fold down-regulated; 149 miRNAs were expressing at 48 h post injury, in which 16 miRNAs were more than 2-fold up-regulated, and 11 miRNAs were more than 2-fold down-regulated; and 203 miRNAs were expressing at 72 h post injury, in which 19 miRNAs were more than 2-fold up-regulated, and 5 miRNAs were more than 2-fold down-regulated. "
],
"offsets": [
[
323,
971
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]
},
{
"id": "2411",
"type": "abstract",
"text": [
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],
"offsets": [
[
972,
1114
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]
},
{
"id": "2412",
"type": "abstract",
"text": [
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],
"offsets": [
[
1115,
1329
]
]
},
{
"id": "2413",
"type": "abstract",
"text": [
"In this report, we describe the miRNA expression level in rat cerebral cortex after traumatic brain injury using microarray method. "
],
"offsets": [
[
1330,
1462
]
]
},
{
"id": "2414",
"type": "abstract",
"text": [
"We choose several time points post brain injury: 6 h, 24 h, 48 h and 72 h, respectively, to reveal differential expression of miRNAs in rat brain cortex compared with control groups. "
],
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[
1463,
1646
]
]
},
{
"id": "2415",
"type": "abstract",
"text": [
"Microarray based analysis of microRNA expression in rat cerebral cortex after traumatic brain injury. "
],
"offsets": [
[
1647,
1750
]
]
}
] | [
{
"id": "2416",
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142,
148
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},
{
"id": "2417",
"type": "Diseases",
"text": [
"traumatic brain injury"
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82,
104
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]
},
{
"id": "2418",
"type": "Diseases",
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"TBI"
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195,
198
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"db_id": "miRNA-corp.d50.s0.e2"
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]
},
{
"id": "2419",
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33,
41
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]
},
{
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125,
133
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]
},
{
"id": "2421",
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"rat"
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56,
59
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]
},
{
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"type": "Specific_miRNAs",
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259,
265
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"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d50.s1.e0"
}
]
},
{
"id": "2423",
"type": "Diseases",
"text": [
"injury"
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314,
320
]
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{
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"db_id": "miRNA-corp.d50.s1.e1"
}
]
},
{
"id": "2424",
"type": "Relation_Trigger",
"text": [
"up-regulation"
],
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[
242,
255
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],
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"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d50.s1.e2"
}
]
},
{
"id": "2425",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
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354,
360
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],
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"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d50.s2.e0"
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]
},
{
"id": "2426",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
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409,
415
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"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d50.s2.e1"
}
]
},
{
"id": "2427",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
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459,
465
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"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d50.s2.e2"
}
]
},
{
"id": "2428",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
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508,
514
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{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d50.s2.e3"
}
]
},
{
"id": "2429",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
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[
563,
569
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],
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{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d50.s2.e4"
}
]
},
{
"id": "2430",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
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613,
619
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],
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"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d50.s2.e5"
}
]
},
{
"id": "2431",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
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[
662,
668
]
],
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{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d50.s2.e6"
}
]
},
{
"id": "2432",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
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718,
724
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],
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{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d50.s2.e7"
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]
},
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"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d50.s2.e10",
"arg2_id": "miRNA-corp.d50.s2.e16",
"normalized": []
},
{
"id": "2517",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d50.s2.e10",
"arg2_id": "miRNA-corp.d50.s2.e17",
"normalized": []
},
{
"id": "2518",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d50.s2.e11",
"arg2_id": "miRNA-corp.d50.s2.e14",
"normalized": []
},
{
"id": "2519",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d50.s2.e11",
"arg2_id": "miRNA-corp.d50.s2.e15",
"normalized": []
},
{
"id": "2520",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d50.s2.e11",
"arg2_id": "miRNA-corp.d50.s2.e16",
"normalized": []
},
{
"id": "2521",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d50.s2.e11",
"arg2_id": "miRNA-corp.d50.s2.e17",
"normalized": []
},
{
"id": "2522",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d50.s5.e0",
"arg2_id": "miRNA-corp.d50.s5.e3",
"normalized": []
},
{
"id": "2523",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d50.s5.e1",
"arg2_id": "miRNA-corp.d50.s5.e3",
"normalized": []
},
{
"id": "2524",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d50.s7.e0",
"arg2_id": "miRNA-corp.d50.s7.e1",
"normalized": []
},
{
"id": "2525",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d50.s8.e0",
"arg2_id": "miRNA-corp.d50.s8.e1",
"normalized": []
},
{
"id": "2526",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d50.s9.e1",
"arg2_id": "miRNA-corp.d50.s9.e0",
"normalized": []
}
] |
2569 | miRNA-corp.d51 | [
{
"id": "2528",
"type": "title",
"text": [
"MiR-107 is reduced in Alzheimer's disease brain neocortex: validation study. "
],
"offsets": [
[
0,
78
]
]
},
{
"id": "2529",
"type": "abstract",
"text": [
"MiR-107 is a microRNA (miRNA) that we reported previously to have decreased expression in the temporal cortical gray matter early in the progression of Alzheimer's disease (AD). "
],
"offsets": [
[
79,
257
]
]
},
{
"id": "2530",
"type": "abstract",
"text": [
"Correlation was observed between decreased miR-107 expression and increased neuritic plaque counts (P< 0.05) and neurofibrillary tangle counts (P< 0.02) in adjacent brain tissue. "
],
"offsets": [
[
258,
437
]
]
},
{
"id": "2531",
"type": "abstract",
"text": [
"Adjusted miR-107 and BACE1 mRNA levels tended to correlate negatively (trend with regression P< 0.07). "
],
"offsets": [
[
438,
541
]
]
},
{
"id": "2532",
"type": "abstract",
"text": [
"Here we study a new group of well-characterized human temporal cortex samples (N=19). "
],
"offsets": [
[
542,
628
]
]
},
{
"id": "2533",
"type": "abstract",
"text": [
"MiR-107 expression was assessed, normalized to miR-124 and let-7a. "
],
"offsets": [
[
629,
696
]
]
},
{
"id": "2534",
"type": "abstract",
"text": [
"In sum, miR-107 expression tends to be lower relative to other miRNAs as AD progresses. "
],
"offsets": [
[
697,
787
]
]
}
] | [
{
"id": "2535",
"type": "Specific_miRNAs",
"text": [
"MiR-107"
],
"offsets": [
[
0,
7
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d51.s0.e0"
}
]
},
{
"id": "2536",
"type": "Diseases",
"text": [
"Alzheimer's disease"
],
"offsets": [
[
22,
41
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d51.s0.e1"
}
]
},
{
"id": "2537",
"type": "Non-Specific_miRNAs",
"text": [
"microRNA"
],
"offsets": [
[
92,
100
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d51.s1.e0"
}
]
},
{
"id": "2538",
"type": "Non-Specific_miRNAs",
"text": [
"miRNA"
],
"offsets": [
[
102,
107
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d51.s1.e1"
}
]
},
{
"id": "2539",
"type": "Relation_Trigger",
"text": [
"decreased expression"
],
"offsets": [
[
145,
165
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d51.s1.e2"
}
]
},
{
"id": "2540",
"type": "Diseases",
"text": [
"Alzheimer's disease"
],
"offsets": [
[
231,
250
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d51.s1.e3"
}
]
},
{
"id": "2541",
"type": "Diseases",
"text": [
"AD"
],
"offsets": [
[
252,
254
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d51.s1.e4"
}
]
},
{
"id": "2542",
"type": "Specific_miRNAs",
"text": [
"MiR-107"
],
"offsets": [
[
79,
86
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d51.s1.e5"
}
]
},
{
"id": "2543",
"type": "Relation_Trigger",
"text": [
"decreased miR-107 expression"
],
"offsets": [
[
291,
319
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d51.s2.e0"
}
]
},
{
"id": "2544",
"type": "Specific_miRNAs",
"text": [
"miR-107"
],
"offsets": [
[
301,
308
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d51.s2.e1"
}
]
},
{
"id": "2545",
"type": "Relation_Trigger",
"text": [
"Correlation"
],
"offsets": [
[
258,
269
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d51.s2.e2"
}
]
},
{
"id": "2546",
"type": "Diseases",
"text": [
"neuritic plaque"
],
"offsets": [
[
334,
349
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d51.s2.e3"
}
]
},
{
"id": "2547",
"type": "Relation_Trigger",
"text": [
"correlate negatively"
],
"offsets": [
[
487,
507
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d51.s3.e0"
}
]
},
{
"id": "2548",
"type": "Genes/Proteins",
"text": [
"BACE1"
],
"offsets": [
[
459,
464
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d51.s3.e1"
}
]
},
{
"id": "2549",
"type": "Specific_miRNAs",
"text": [
"miR-107"
],
"offsets": [
[
447,
454
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d51.s3.e2"
}
]
},
{
"id": "2550",
"type": "Species",
"text": [
"human"
],
"offsets": [
[
590,
595
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d51.s4.e0"
}
]
},
{
"id": "2551",
"type": "Specific_miRNAs",
"text": [
"MiR-107"
],
"offsets": [
[
629,
636
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d51.s5.e0"
}
]
},
{
"id": "2552",
"type": "Specific_miRNAs",
"text": [
"miR-124"
],
"offsets": [
[
676,
683
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d51.s5.e1"
}
]
},
{
"id": "2553",
"type": "Specific_miRNAs",
"text": [
"let-7a"
],
"offsets": [
[
688,
694
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d51.s5.e2"
}
]
},
{
"id": "2554",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
[
760,
766
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d51.s6.e0"
}
]
},
{
"id": "2555",
"type": "Relation_Trigger",
"text": [
"expression tends to be lower"
],
"offsets": [
[
713,
741
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d51.s6.e1"
}
]
},
{
"id": "2556",
"type": "Diseases",
"text": [
"AD"
],
"offsets": [
[
770,
772
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d51.s6.e2"
}
]
},
{
"id": "2557",
"type": "Specific_miRNAs",
"text": [
"miR-107"
],
"offsets": [
[
705,
712
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d51.s6.e3"
}
]
}
] | [] | [] | [
{
"id": "2558",
"type": "Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d51.s0.e0",
"arg2_id": "miRNA-corp.d51.s0.e1",
"normalized": []
},
{
"id": "2559",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d51.s1.e0",
"arg2_id": "miRNA-corp.d51.s1.e4",
"normalized": []
},
{
"id": "2560",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d51.s1.e0",
"arg2_id": "miRNA-corp.d51.s1.e3",
"normalized": []
},
{
"id": "2561",
"type": "Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d51.s1.e5",
"arg2_id": "miRNA-corp.d51.s1.e4",
"normalized": []
},
{
"id": "2562",
"type": "Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d51.s1.e5",
"arg2_id": "miRNA-corp.d51.s1.e3",
"normalized": []
},
{
"id": "2563",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d51.s1.e1",
"arg2_id": "miRNA-corp.d51.s1.e4",
"normalized": []
},
{
"id": "2564",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d51.s1.e1",
"arg2_id": "miRNA-corp.d51.s1.e3",
"normalized": []
},
{
"id": "2565",
"type": "Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d51.s2.e1",
"arg2_id": "miRNA-corp.d51.s2.e3",
"normalized": []
},
{
"id": "2566",
"type": "Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d51.s3.e2",
"arg2_id": "miRNA-corp.d51.s3.e1",
"normalized": []
},
{
"id": "2567",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d51.s6.e0",
"arg2_id": "miRNA-corp.d51.s6.e2",
"normalized": []
},
{
"id": "2568",
"type": "Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d51.s6.e3",
"arg2_id": "miRNA-corp.d51.s6.e2",
"normalized": []
}
] |
2588 | miRNA-corp.d52 | [
{
"id": "2570",
"type": "title",
"text": [
"Small RNAs are short (approximately 18 to 30 nucleotides), non-coding RNA molecules that can regulate gene expression in both the cytoplasm and the nucleus via post-transcriptional gene silencing (PTGS), chromatin-dependent gene silencing (CDGS) or RNA activation (RNAa). "
],
"offsets": [
[
0,
272
]
]
},
{
"id": "2571",
"type": "abstract",
"text": [
"Three classes of small RNAs have been defined: microRNAs (miRNAs), siRNAs and Piwi-interacting RNAs (piRNAs). "
],
"offsets": [
[
273,
383
]
]
},
{
"id": "2572",
"type": "abstract",
"text": [
"More interestingly, increasing evidence indicates that small RNAs are involved in the pathogenesis of diverse diseases including cancer, cardiovascular disease, stroke, neurodegenerative disease, diabetes, liver disease, kidney disease and infectious disease. "
],
"offsets": [
[
384,
644
]
]
},
{
"id": "2573",
"type": "abstract",
"text": [
"Accordingly, small RNAs are critical regulators of normal development and physiology. "
],
"offsets": [
[
645,
731
]
]
},
{
"id": "2574",
"type": "abstract",
"text": [
"Additionally, small RNAs may serve as novel biomarkers and therapeutic targets for the majority of diseases. "
],
"offsets": [
[
732,
843
]
]
}
] | [
{
"id": "2575",
"type": "Relation_Trigger",
"text": [
"regulate gene expression"
],
"offsets": [
[
93,
117
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d52.s0.e0"
}
]
},
{
"id": "2576",
"type": "Non-Specific_miRNAs",
"text": [
"microRNAs"
],
"offsets": [
[
320,
329
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d52.s3.e0"
}
]
},
{
"id": "2577",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
[
331,
337
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d52.s3.e1"
}
]
},
{
"id": "2578",
"type": "Diseases",
"text": [
"cardiovascular disease"
],
"offsets": [
[
521,
543
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d52.s4.e0"
}
]
},
{
"id": "2579",
"type": "Diseases",
"text": [
"stroke"
],
"offsets": [
[
545,
551
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d52.s4.e1"
}
]
},
{
"id": "2580",
"type": "Diseases",
"text": [
"neurodegenerative disease"
],
"offsets": [
[
553,
578
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d52.s4.e2"
}
]
},
{
"id": "2581",
"type": "Diseases",
"text": [
"diabetes"
],
"offsets": [
[
580,
588
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d52.s4.e3"
}
]
},
{
"id": "2582",
"type": "Diseases",
"text": [
"liver disease"
],
"offsets": [
[
590,
603
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d52.s4.e4"
}
]
},
{
"id": "2583",
"type": "Diseases",
"text": [
"kidney disease"
],
"offsets": [
[
605,
619
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d52.s4.e5"
}
]
},
{
"id": "2584",
"type": "Diseases",
"text": [
"infectious disease"
],
"offsets": [
[
624,
642
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d52.s4.e6"
}
]
},
{
"id": "2585",
"type": "Diseases",
"text": [
"cancer"
],
"offsets": [
[
513,
519
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d52.s4.e7"
}
]
},
{
"id": "2586",
"type": "Relation_Trigger",
"text": [
"regulators"
],
"offsets": [
[
682,
692
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d52.s5.e0"
}
]
},
{
"id": "2587",
"type": "Relation_Trigger",
"text": [
"therapeutic targets"
],
"offsets": [
[
791,
810
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d52.s6.e0"
}
]
}
] | [] | [] | [] |
2681 | miRNA-corp.d53 | [
{
"id": "2589",
"type": "title",
"text": [
"We studied the expression of selected miRNAs following infection of CBA mice with Plasmodium berghei ANKA (PbA), which causes cerebral malaria (CM), or Plasmodium berghei K173 (PbK), which causes severe malaria but without cerebral complications, termed non-CM. "
],
"offsets": [
[
0,
262
]
]
},
{
"id": "2590",
"type": "abstract",
"text": [
"MicroRNAs (miRNAs) are posttranscriptional regulatory molecules that have been implicated in the regulation of immune responses, but their role in the immune response to Plasmodium infection is unknown. "
],
"offsets": [
[
263,
466
]
]
},
{
"id": "2591",
"type": "abstract",
"text": [
"Differential MicroRNA Expression in Experimental Cerebral and Noncerebral Malaria. "
],
"offsets": [
[
467,
551
]
]
},
{
"id": "2592",
"type": "abstract",
"text": [
"To investigate the involvement of let-7i, miR-27a, and miR-150 in CM-resistant mice, we assessed the expression levels in gamma interferon knockout (IFN-γ(-/-)) mice on a C57BL/6 genetic background. "
],
"offsets": [
[
552,
751
]
]
},
{
"id": "2593",
"type": "abstract",
"text": [
"In contrast, no miRNA changes were detected in the heart, an organ with no known pathology during acute malaria. "
],
"offsets": [
[
752,
865
]
]
},
{
"id": "2594",
"type": "abstract",
"text": [
"We identified three miRNAs that were differentially expressed in the brain of PbA-infected CBA mice: let7i, miR-27a, and miR-150. "
],
"offsets": [
[
866,
996
]
]
},
{
"id": "2595",
"type": "abstract",
"text": [
"The differential expression profiles of selected miRNAs (let-7i, miR-27a, miR-150, miR-126, miR-210, and miR-155) were analyzed in mouse brain and heart tissue by quantitative reverse transcription-PCR (qRT-PCR). "
],
"offsets": [
[
997,
1210
]
]
},
{
"id": "2596",
"type": "abstract",
"text": [
"Our data suggest that in the CBA mouse at least, miRNA may have a regulatory role in the pathogenesis of severe malaria. "
],
"offsets": [
[
1211,
1334
]
]
},
{
"id": "2597",
"type": "abstract",
"text": [
"Overexpression of these three miRNAs during PbA, but not PbK, infection in WT mice may be critical for the triggering of the neurological syndrome via regulation of their potential downstream targets. "
],
"offsets": [
[
1335,
1536
]
]
},
{
"id": "2598",
"type": "abstract",
"text": [
"The expression of let-7i, miR-27a, and miR-150 was unchanged in both wild-type (WT) and IFN-γ(-/-) mice following infection. "
],
"offsets": [
[
1537,
1662
]
]
}
] | [
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"id": "2674",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d53.s8.e0",
"arg2_id": "miRNA-corp.d53.s8.e5",
"normalized": []
},
{
"id": "2675",
"type": "Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d53.s9.e1",
"arg2_id": "miRNA-corp.d53.s9.e0",
"normalized": []
},
{
"id": "2676",
"type": "Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d53.s9.e1",
"arg2_id": "miRNA-corp.d53.s9.e4",
"normalized": []
},
{
"id": "2677",
"type": "Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d53.s9.e2",
"arg2_id": "miRNA-corp.d53.s9.e0",
"normalized": []
},
{
"id": "2678",
"type": "Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d53.s9.e2",
"arg2_id": "miRNA-corp.d53.s9.e4",
"normalized": []
},
{
"id": "2679",
"type": "Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d53.s9.e3",
"arg2_id": "miRNA-corp.d53.s9.e0",
"normalized": []
},
{
"id": "2680",
"type": "Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d53.s9.e3",
"arg2_id": "miRNA-corp.d53.s9.e4",
"normalized": []
}
] |
2699 | miRNA-corp.d54 | [
{
"id": "2682",
"type": "title",
"text": [
"We also discuss the implications of these findings with respect to the involvement of miRNAs in the etiopathology of brain disorders and pinpoint the emerging therapeutic potential of miRNAs for the treatment of human diseases. "
],
"offsets": [
[
0,
230
]
]
},
{
"id": "2683",
"type": "abstract",
"text": [
"We focus on the role of the miRNA pathway in brain development, function, and disease by highlighting recent observations with respect to miRNA-mediated gene regulation in neuronal differentiation, synaptic plasticity, and the circadian clock. "
],
"offsets": [
[
231,
475
]
]
},
{
"id": "2684",
"type": "abstract",
"text": [
"MicroRNAs in brain function and disease. "
],
"offsets": [
[
476,
518
]
]
},
{
"id": "2685",
"type": "abstract",
"text": [
"MicroRNAs (miRNAs), a class of small, non-protein-coding transcripts about 21 nucleotides long, have recently entered center stage in the study of posttranscriptional gene regulation. "
],
"offsets": [
[
519,
703
]
]
}
] | [
{
"id": "2686",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
[
86,
92
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d54.s0.e0"
}
]
},
{
"id": "2687",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
[
184,
190
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d54.s0.e1"
}
]
},
{
"id": "2688",
"type": "Diseases",
"text": [
"brain disorders"
],
"offsets": [
[
117,
132
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d54.s0.e2"
}
]
},
{
"id": "2689",
"type": "Species",
"text": [
"human"
],
"offsets": [
[
212,
217
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d54.s0.e3"
}
]
},
{
"id": "2690",
"type": "Relation_Trigger",
"text": [
"regulation"
],
"offsets": [
[
389,
399
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d54.s2.e0"
}
]
},
{
"id": "2691",
"type": "Non-Specific_miRNAs",
"text": [
"miRNA"
],
"offsets": [
[
369,
374
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d54.s2.e1"
}
]
},
{
"id": "2692",
"type": "Non-Specific_miRNAs",
"text": [
"miRNA"
],
"offsets": [
[
259,
264
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d54.s2.e2"
}
]
},
{
"id": "2693",
"type": "Non-Specific_miRNAs",
"text": [
"MicroRNAs"
],
"offsets": [
[
476,
485
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d54.s3.e0"
}
]
},
{
"id": "2694",
"type": "Non-Specific_miRNAs",
"text": [
"MicroRNAs"
],
"offsets": [
[
519,
528
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d54.s4.e0"
}
]
},
{
"id": "2695",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
[
530,
536
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d54.s4.e1"
}
]
},
{
"id": "2696",
"type": "Relation_Trigger",
"text": [
"regulation"
],
"offsets": [
[
691,
701
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d54.s4.e2"
}
]
}
] | [] | [] | [
{
"id": "2697",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d54.s0.e0",
"arg2_id": "miRNA-corp.d54.s0.e2",
"normalized": []
},
{
"id": "2698",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d54.s0.e1",
"arg2_id": "miRNA-corp.d54.s0.e2",
"normalized": []
}
] |
2743 | miRNA-corp.d55 | [
{
"id": "2700",
"type": "title",
"text": [
"In an effort to shed light on consequences mediated by p53 inactivation in gliomas, we established the Tet-On system for p53 in the LN-Z308 glioblastoma cell line. "
],
"offsets": [
[
0,
164
]
]
},
{
"id": "2701",
"type": "abstract",
"text": [
"p53 is activated upon various kinds of cellular stress leading to apoptosis or cell cycle arrest, but is also implicated in complex biological processes such as inhibition of angiogenesis and metastasis. "
],
"offsets": [
[
165,
369
]
]
},
{
"id": "2702",
"type": "abstract",
"text": [
"Oxygen deprivation, an important cellular stress, revealed MIC-1 as an anoxia responsive gene in glioblastoma cell lines. "
],
"offsets": [
[
370,
492
]
]
},
{
"id": "2703",
"type": "abstract",
"text": [
"The macrophage inhibitory cytokine-1 (MIC-1) gene was identified as a most prominent p53 target gene upon gene expression profiling. "
],
"offsets": [
[
493,
626
]
]
},
{
"id": "2704",
"type": "abstract",
"text": [
"Furthermore, ectopic expression of MIC-1 in LN-Z308 cell line completely abolished its inherent tumorigenicity in nude mice, while proliferation in vitro was not affected. "
],
"offsets": [
[
627,
799
]
]
},
{
"id": "2705",
"type": "abstract",
"text": [
"MIC-1 up-regulation by anoxia is mediated through an alternative, p53 and hypoxia inducible factor 1 (HIF-1) independent pathway. "
],
"offsets": [
[
800,
930
]
]
},
{
"id": "2706",
"type": "abstract",
"text": [
"Taken together, these data suggest that MIC-1 is an important downstream mediator of p53 function, while acting itself as an intercessor of cellular stress signaling and exerting anti-tumorigenic activities. "
],
"offsets": [
[
931,
1141
]
]
},
{
"id": "2707",
"type": "abstract",
"text": [
"In the present experimental model MIC-1 may exert its anti-tumorigenic properties via a paracrine mechanism mediated by host cells in vivo. "
],
"offsets": [
[
1142,
1282
]
]
},
{
"id": "2708",
"type": "abstract",
"text": [
"Human astrocytic brain tumors select for mutations in the p53 tumor suppressor gene early in malignant progression. "
],
"offsets": [
[
1283,
1399
]
]
},
{
"id": "2709",
"type": "abstract",
"text": [
"Anoxia induces macrophage inhibitory cytokine-1 (MIC-1) in glioblastoma cells independently of p53 and HIF-1. "
],
"offsets": [
[
1400,
1511
]
]
}
] | [
{
"id": "2710",
"type": "Diseases",
"text": [
"glioblastoma"
],
"offsets": [
[
140,
152
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d55.s0.e0"
}
]
},
{
"id": "2711",
"type": "Genes/Proteins",
"text": [
"p53"
],
"offsets": [
[
55,
58
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d55.s0.e1"
}
]
},
{
"id": "2712",
"type": "Diseases",
"text": [
"gliomas"
],
"offsets": [
[
75,
82
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d55.s0.e2"
}
]
},
{
"id": "2713",
"type": "Genes/Proteins",
"text": [
"p53"
],
"offsets": [
[
121,
124
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d55.s0.e3"
}
]
},
{
"id": "2714",
"type": "Relation_Trigger",
"text": [
"activated"
],
"offsets": [
[
172,
181
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d55.s1.e0"
}
]
},
{
"id": "2715",
"type": "Genes/Proteins",
"text": [
"p53"
],
"offsets": [
[
165,
168
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d55.s1.e1"
}
]
},
{
"id": "2716",
"type": "Relation_Trigger",
"text": [
"inhibition"
],
"offsets": [
[
326,
336
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d55.s1.e2"
}
]
},
{
"id": "2717",
"type": "Diseases",
"text": [
"glioblastoma"
],
"offsets": [
[
467,
479
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d55.s2.e0"
}
]
},
{
"id": "2718",
"type": "Genes/Proteins",
"text": [
"MIC-1"
],
"offsets": [
[
429,
434
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d55.s2.e1"
}
]
},
{
"id": "2719",
"type": "Diseases",
"text": [
"anoxia"
],
"offsets": [
[
441,
447
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d55.s2.e2"
}
]
},
{
"id": "2720",
"type": "Relation_Trigger",
"text": [
"target"
],
"offsets": [
[
582,
588
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d55.s3.e0"
}
]
},
{
"id": "2721",
"type": "Genes/Proteins",
"text": [
"macrophage inhibitory cytokine-1"
],
"offsets": [
[
497,
529
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d55.s3.e1"
}
]
},
{
"id": "2722",
"type": "Genes/Proteins",
"text": [
"MIC-1"
],
"offsets": [
[
531,
536
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d55.s3.e2"
}
]
},
{
"id": "2723",
"type": "Genes/Proteins",
"text": [
"p53"
],
"offsets": [
[
578,
581
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d55.s3.e3"
}
]
},
{
"id": "2724",
"type": "Genes/Proteins",
"text": [
"MIC-1"
],
"offsets": [
[
662,
667
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d55.s4.e0"
}
]
},
{
"id": "2725",
"type": "Relation_Trigger",
"text": [
"ectopic expression"
],
"offsets": [
[
640,
658
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d55.s4.e1"
}
]
},
{
"id": "2726",
"type": "Species",
"text": [
"nude mice"
],
"offsets": [
[
741,
750
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d55.s4.e2"
}
]
},
{
"id": "2727",
"type": "Genes/Proteins",
"text": [
"p53"
],
"offsets": [
[
866,
869
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d55.s5.e0"
}
]
},
{
"id": "2728",
"type": "Genes/Proteins",
"text": [
"MIC-1"
],
"offsets": [
[
800,
805
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d55.s5.e1"
}
]
},
{
"id": "2729",
"type": "Diseases",
"text": [
"anoxia"
],
"offsets": [
[
823,
829
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d55.s5.e2"
}
]
},
{
"id": "2730",
"type": "Relation_Trigger",
"text": [
"up-regulation"
],
"offsets": [
[
806,
819
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d55.s5.e3"
}
]
},
{
"id": "2731",
"type": "Genes/Proteins",
"text": [
"p53"
],
"offsets": [
[
1016,
1019
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d55.s6.e0"
}
]
},
{
"id": "2732",
"type": "Genes/Proteins",
"text": [
"MIC-1"
],
"offsets": [
[
971,
976
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d55.s6.e1"
}
]
},
{
"id": "2733",
"type": "Genes/Proteins",
"text": [
"MIC-1"
],
"offsets": [
[
1176,
1181
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d55.s7.e0"
}
]
},
{
"id": "2734",
"type": "Relation_Trigger",
"text": [
"tumor suppressor"
],
"offsets": [
[
1345,
1361
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d55.s8.e0"
}
]
},
{
"id": "2735",
"type": "Diseases",
"text": [
"astrocytic brain tumors"
],
"offsets": [
[
1289,
1312
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d55.s8.e1"
}
]
},
{
"id": "2736",
"type": "Genes/Proteins",
"text": [
"p53"
],
"offsets": [
[
1341,
1344
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d55.s8.e2"
}
]
},
{
"id": "2737",
"type": "Species",
"text": [
"Human"
],
"offsets": [
[
1283,
1288
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d55.s8.e3"
}
]
},
{
"id": "2738",
"type": "Genes/Proteins",
"text": [
"p53"
],
"offsets": [
[
1495,
1498
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d55.s9.e0"
}
]
},
{
"id": "2739",
"type": "Genes/Proteins",
"text": [
"macrophage inhibitory cytokine-1"
],
"offsets": [
[
1415,
1447
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d55.s9.e1"
}
]
},
{
"id": "2740",
"type": "Genes/Proteins",
"text": [
"MIC-1"
],
"offsets": [
[
1449,
1454
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d55.s9.e2"
}
]
},
{
"id": "2741",
"type": "Diseases",
"text": [
"Anoxia"
],
"offsets": [
[
1400,
1406
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d55.s9.e3"
}
]
},
{
"id": "2742",
"type": "Diseases",
"text": [
"glioblastoma"
],
"offsets": [
[
1459,
1471
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d55.s9.e4"
}
]
}
] | [] | [] | [] |
2784 | miRNA-corp.d56 | [
{
"id": "2744",
"type": "title",
"text": [
"This approach protected HSCs from GALC toxicity and allowed successful treatment of a mouse GLD model, providing a rationale to explore HSC-based gene therapy for GLD. "
],
"offsets": [
[
0,
170
]
]
},
{
"id": "2745",
"type": "abstract",
"text": [
"Globoid cell leukodystrophy (GLD; also known as Krabbe disease) is an invariably fatal lysosomal storage disorder caused by mutations in the galactocerebrosidase (GALC) gene. "
],
"offsets": [
[
171,
346
]
]
},
{
"id": "2746",
"type": "abstract",
"text": [
"Hematopoietic stem cell (HSC)-based gene therapy is being explored for GLD; however, we found that forced GALC expression was toxic to HSCs and early progenitors, highlighting the need for improved regulation of vector expression. "
],
"offsets": [
[
347,
578
]
]
},
{
"id": "2747",
"type": "abstract",
"text": [
"Identification of hematopoietic stem cell-specific miRNAs enables gene therapy of globoid cell leukodystrophy. "
],
"offsets": [
[
579,
691
]
]
},
{
"id": "2748",
"type": "abstract",
"text": [
"Moreover, repopulating HSCs could be purified solely on the basis of miRNA expression, providing a new method relevant for human HSC isolation. "
],
"offsets": [
[
692,
836
]
]
},
{
"id": "2749",
"type": "abstract",
"text": [
"By incorporating miR-126 target sequences into a GALC-expressing vector, we suppressed GALC expression in HSCs while maintaining robust expression in mature hematopoietic cells. "
],
"offsets": [
[
837,
1015
]
]
},
{
"id": "2750",
"type": "abstract",
"text": [
"We used a genetic reporter strategy based on lentiviral vectors to detect microRNA activity in hematopoietic cells at single-cell resolution. "
],
"offsets": [
[
1016,
1158
]
]
},
{
"id": "2751",
"type": "abstract",
"text": [
"We report that miR-126 and miR-130a were expressed in HSCs and early progenitors from both mice and humans, but not in differentiated progeny. "
],
"offsets": [
[
1159,
1302
]
]
}
] | [
{
"id": "2752",
"type": "Genes/Proteins",
"text": [
"GALC"
],
"offsets": [
[
34,
38
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d56.s0.e0"
}
]
},
{
"id": "2753",
"type": "Diseases",
"text": [
"GLD"
],
"offsets": [
[
92,
95
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d56.s0.e1"
}
]
},
{
"id": "2754",
"type": "Diseases",
"text": [
"GLD"
],
"offsets": [
[
163,
166
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d56.s0.e2"
}
]
},
{
"id": "2755",
"type": "Species",
"text": [
"mouse"
],
"offsets": [
[
86,
91
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d56.s0.e3"
}
]
},
{
"id": "2756",
"type": "Diseases",
"text": [
"Globoid cell leukodystrophy"
],
"offsets": [
[
171,
198
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d56.s1.e0"
}
]
},
{
"id": "2757",
"type": "Diseases",
"text": [
"GLD"
],
"offsets": [
[
200,
203
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d56.s1.e1"
}
]
},
{
"id": "2758",
"type": "Diseases",
"text": [
"Krabbe disease"
],
"offsets": [
[
219,
233
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d56.s1.e2"
}
]
},
{
"id": "2759",
"type": "Genes/Proteins",
"text": [
"galactocerebrosidase"
],
"offsets": [
[
312,
332
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d56.s1.e3"
}
]
},
{
"id": "2760",
"type": "Genes/Proteins",
"text": [
"GALC"
],
"offsets": [
[
334,
338
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d56.s1.e4"
}
]
},
{
"id": "2761",
"type": "Diseases",
"text": [
"fatal lysosomal storage disorder"
],
"offsets": [
[
252,
284
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d56.s1.e5"
}
]
},
{
"id": "2762",
"type": "Genes/Proteins",
"text": [
"GALC"
],
"offsets": [
[
453,
457
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d56.s2.e0"
}
]
},
{
"id": "2763",
"type": "Diseases",
"text": [
"GLD"
],
"offsets": [
[
418,
421
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d56.s2.e1"
}
]
},
{
"id": "2764",
"type": "Relation_Trigger",
"text": [
"regulation of vector expression"
],
"offsets": [
[
545,
576
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d56.s2.e2"
}
]
},
{
"id": "2765",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
[
630,
636
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d56.s3.e0"
}
]
},
{
"id": "2766",
"type": "Diseases",
"text": [
"globoid cell leukodystrophy"
],
"offsets": [
[
661,
688
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d56.s3.e1"
}
]
},
{
"id": "2767",
"type": "Non-Specific_miRNAs",
"text": [
"miRNA"
],
"offsets": [
[
761,
766
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d56.s4.e0"
}
]
},
{
"id": "2768",
"type": "Species",
"text": [
"human"
],
"offsets": [
[
815,
820
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d56.s4.e1"
}
]
},
{
"id": "2769",
"type": "Relation_Trigger",
"text": [
"suppressed GALC expression"
],
"offsets": [
[
913,
939
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d56.s5.e0"
}
]
},
{
"id": "2770",
"type": "Specific_miRNAs",
"text": [
"miR-126"
],
"offsets": [
[
854,
861
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d56.s5.e1"
}
]
},
{
"id": "2771",
"type": "Genes/Proteins",
"text": [
"GALC"
],
"offsets": [
[
924,
928
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d56.s5.e2"
}
]
},
{
"id": "2772",
"type": "Relation_Trigger",
"text": [
"target"
],
"offsets": [
[
862,
868
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d56.s5.e3"
}
]
},
{
"id": "2773",
"type": "Genes/Proteins",
"text": [
"GALC"
],
"offsets": [
[
924,
928
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d56.s5.e4"
}
]
},
{
"id": "2774",
"type": "Genes/Proteins",
"text": [
"GALC"
],
"offsets": [
[
886,
890
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d56.s5.e5"
}
]
},
{
"id": "2775",
"type": "Non-Specific_miRNAs",
"text": [
"microRNA"
],
"offsets": [
[
1090,
1098
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d56.s6.e0"
}
]
},
{
"id": "2776",
"type": "Specific_miRNAs",
"text": [
"miR-126"
],
"offsets": [
[
1174,
1181
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d56.s7.e0"
}
]
},
{
"id": "2777",
"type": "Specific_miRNAs",
"text": [
"miR-130a"
],
"offsets": [
[
1186,
1194
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d56.s7.e1"
}
]
},
{
"id": "2778",
"type": "Species",
"text": [
"mice"
],
"offsets": [
[
1250,
1254
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d56.s7.e2"
}
]
},
{
"id": "2779",
"type": "Species",
"text": [
"humans"
],
"offsets": [
[
1259,
1265
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d56.s7.e3"
}
]
}
] | [] | [] | [
{
"id": "2780",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d56.s3.e0",
"arg2_id": "miRNA-corp.d56.s3.e1",
"normalized": []
},
{
"id": "2781",
"type": "Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d56.s5.e1",
"arg2_id": "miRNA-corp.d56.s5.e2",
"normalized": []
},
{
"id": "2782",
"type": "Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d56.s5.e1",
"arg2_id": "miRNA-corp.d56.s5.e4",
"normalized": []
},
{
"id": "2783",
"type": "Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d56.s5.e1",
"arg2_id": "miRNA-corp.d56.s5.e5",
"normalized": []
}
] |
2813 | miRNA-corp.d57 | [
{
"id": "2785",
"type": "title",
"text": [
"The genomic sequences predict that miRNAs are likely to be derived from larger precursors that have the capacity to form stem-loop structures. "
],
"offsets": [
[
0,
144
]
]
},
{
"id": "2786",
"type": "abstract",
"text": [
"Here we report that Gemin3 and Gemin4 are also in a separate complex that contains eIF2C2, a member of the Argonaute protein family. "
],
"offsets": [
[
145,
278
]
]
},
{
"id": "2787",
"type": "abstract",
"text": [
"We describe 40 miRNAs, a few of which are identical to recently described human miRNAs, a class of small endogenous RNAs. "
],
"offsets": [
[
279,
401
]
]
},
{
"id": "2788",
"type": "abstract",
"text": [
"This novel complex is a large approximately 15S RNP that contains numerous microRNAs (miRNAs). "
],
"offsets": [
[
402,
497
]
]
},
{
"id": "2789",
"type": "abstract",
"text": [
"miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs. "
],
"offsets": [
[
498,
574
]
]
},
{
"id": "2790",
"type": "abstract",
"text": [
"Reduction in SMN protein results in Spinal muscular atrophy (SMA), a common neurodegenerative disease. "
],
"offsets": [
[
575,
678
]
]
},
{
"id": "2791",
"type": "abstract",
"text": [
"Gemin3 is a DEAD-box RNA helicase that binds to the Survival of Motor Neurons (SMN) protein and is a component of the SMN complex, which also comprises SMN, Gemin2, Gemin4, Gemin5, and Gemin6. "
],
"offsets": [
[
679,
872
]
]
}
] | [
{
"id": "2792",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
[
35,
41
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d57.s0.e0"
}
]
},
{
"id": "2793",
"type": "Genes/Proteins",
"text": [
"Gemin3"
],
"offsets": [
[
165,
171
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d57.s1.e0"
}
]
},
{
"id": "2794",
"type": "Genes/Proteins",
"text": [
"Gemin4"
],
"offsets": [
[
176,
182
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d57.s1.e1"
}
]
},
{
"id": "2795",
"type": "Genes/Proteins",
"text": [
"eIF2C2"
],
"offsets": [
[
228,
234
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d57.s1.e2"
}
]
},
{
"id": "2796",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
[
294,
300
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d57.s3.e0"
}
]
},
{
"id": "2797",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
[
359,
365
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d57.s3.e1"
}
]
},
{
"id": "2798",
"type": "Species",
"text": [
"human"
],
"offsets": [
[
353,
358
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d57.s3.e2"
}
]
},
{
"id": "2799",
"type": "Non-Specific_miRNAs",
"text": [
"microRNAs"
],
"offsets": [
[
477,
486
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d57.s4.e0"
}
]
},
{
"id": "2800",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
[
488,
494
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d57.s4.e1"
}
]
},
{
"id": "2801",
"type": "Non-Specific_miRNAs",
"text": [
"microRNAs"
],
"offsets": [
[
562,
571
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d57.s5.e0"
}
]
},
{
"id": "2802",
"type": "Diseases",
"text": [
"Spinal muscular atrophy"
],
"offsets": [
[
611,
634
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d57.s6.e0"
}
]
},
{
"id": "2803",
"type": "Diseases",
"text": [
"SMA"
],
"offsets": [
[
636,
639
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d57.s6.e1"
}
]
},
{
"id": "2804",
"type": "Diseases",
"text": [
"neurodegenerative disease"
],
"offsets": [
[
651,
676
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d57.s6.e2"
}
]
},
{
"id": "2805",
"type": "Relation_Trigger",
"text": [
"Reduction in SMN protein"
],
"offsets": [
[
575,
599
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d57.s6.e3"
}
]
},
{
"id": "2806",
"type": "Genes/Proteins",
"text": [
"Gemin2"
],
"offsets": [
[
836,
842
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d57.s7.e0"
}
]
},
{
"id": "2807",
"type": "Genes/Proteins",
"text": [
"Gemin4"
],
"offsets": [
[
844,
850
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d57.s7.e1"
}
]
},
{
"id": "2808",
"type": "Genes/Proteins",
"text": [
"Gemin5"
],
"offsets": [
[
852,
858
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d57.s7.e2"
}
]
},
{
"id": "2809",
"type": "Genes/Proteins",
"text": [
"Gemin6"
],
"offsets": [
[
864,
870
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d57.s7.e3"
}
]
},
{
"id": "2810",
"type": "Genes/Proteins",
"text": [
"DEAD-box RNA helicase"
],
"offsets": [
[
691,
712
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d57.s7.e4"
}
]
},
{
"id": "2811",
"type": "Genes/Proteins",
"text": [
"Gemin3"
],
"offsets": [
[
679,
685
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d57.s7.e5"
}
]
},
{
"id": "2812",
"type": "Relation_Trigger",
"text": [
"binds"
],
"offsets": [
[
718,
723
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d57.s7.e6"
}
]
}
] | [] | [] | [] |
2855 | miRNA-corp.d58 | [
{
"id": "2814",
"type": "title",
"text": [
"Defective RNA metabolism is an emerging mechanism involved in ALS pathogenesis and possibly in other neurodegenerative disorders. "
],
"offsets": [
[
0,
130
]
]
},
{
"id": "2815",
"type": "abstract",
"text": [
"miRNA malfunction causes spinal motor neuron disease. "
],
"offsets": [
[
131,
186
]
]
},
{
"id": "2816",
"type": "abstract",
"text": [
"Thus, mice that do not process miRNA in SMNs exhibit hallmarks of spinal muscular atrophy (SMA), including sclerosis of the spinal cord ventral horns, aberrant end plate architecture, and myofiber atrophy with signs of denervation. "
],
"offsets": [
[
187,
419
]
]
},
{
"id": "2817",
"type": "abstract",
"text": [
"Here, we show that microRNA (miRNA) activity is essential for long-term survival of postmitotic spinal motor neurons (SMNs) in vivo. "
],
"offsets": [
[
420,
553
]
]
},
{
"id": "2818",
"type": "abstract",
"text": [
"We demonstrate that the heavy neurofilament subunit is a target of miR-9, a miRNA that is specifically down-regulated in a genetic model of SMA. "
],
"offsets": [
[
554,
699
]
]
},
{
"id": "2819",
"type": "abstract",
"text": [
"Furthermore, a neurofilament heavy subunit previously implicated in motor neuron degeneration is specifically up-regulated in miRNA-deficient SMNs. "
],
"offsets": [
[
700,
848
]
]
},
{
"id": "2820",
"type": "abstract",
"text": [
"These data provide evidence for miRNA function in SMN diseases and emphasize the potential role of miR-9-based regulatory mechanisms in adult neurons and neurodegenerative states. "
],
"offsets": [
[
849,
1031
]
]
}
] | [
{
"id": "2821",
"type": "Diseases",
"text": [
"ALS"
],
"offsets": [
[
62,
65
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d58.s0.e0"
}
]
},
{
"id": "2822",
"type": "Diseases",
"text": [
"neurodegenerative disorders"
],
"offsets": [
[
101,
128
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d58.s0.e1"
}
]
},
{
"id": "2823",
"type": "Non-Specific_miRNAs",
"text": [
"miRNA"
],
"offsets": [
[
131,
136
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d58.s1.e0"
}
]
},
{
"id": "2824",
"type": "Diseases",
"text": [
"spinal motor neuron disease"
],
"offsets": [
[
156,
183
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d58.s1.e1"
}
]
},
{
"id": "2825",
"type": "Diseases",
"text": [
"spinal muscular atrophy"
],
"offsets": [
[
253,
276
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d58.s2.e0"
}
]
},
{
"id": "2826",
"type": "Diseases",
"text": [
"SMA"
],
"offsets": [
[
278,
281
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d58.s2.e1"
}
]
},
{
"id": "2827",
"type": "Non-Specific_miRNAs",
"text": [
"miRNA"
],
"offsets": [
[
218,
223
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d58.s2.e2"
}
]
},
{
"id": "2828",
"type": "Diseases",
"text": [
"sclerosis of the spinal cord ventral horns"
],
"offsets": [
[
294,
336
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d58.s2.e3"
}
]
},
{
"id": "2829",
"type": "Diseases",
"text": [
"atrophy"
],
"offsets": [
[
384,
391
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d58.s2.e4"
}
]
},
{
"id": "2830",
"type": "Species",
"text": [
"mice"
],
"offsets": [
[
193,
197
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d58.s2.e5"
}
]
},
{
"id": "2831",
"type": "Non-Specific_miRNAs",
"text": [
"microRNA"
],
"offsets": [
[
439,
447
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d58.s3.e0"
}
]
},
{
"id": "2832",
"type": "Non-Specific_miRNAs",
"text": [
"miRNA"
],
"offsets": [
[
449,
454
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d58.s3.e1"
}
]
},
{
"id": "2833",
"type": "Specific_miRNAs",
"text": [
"miR-9"
],
"offsets": [
[
621,
626
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d58.s4.e0"
}
]
},
{
"id": "2834",
"type": "Diseases",
"text": [
"SMA"
],
"offsets": [
[
694,
697
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d58.s4.e1"
}
]
},
{
"id": "2835",
"type": "Non-Specific_miRNAs",
"text": [
"miRNA"
],
"offsets": [
[
630,
635
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d58.s4.e2"
}
]
},
{
"id": "2836",
"type": "Relation_Trigger",
"text": [
"target"
],
"offsets": [
[
611,
617
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d58.s4.e3"
}
]
},
{
"id": "2837",
"type": "Relation_Trigger",
"text": [
"down-regulated"
],
"offsets": [
[
657,
671
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d58.s4.e4"
}
]
},
{
"id": "2838",
"type": "Non-Specific_miRNAs",
"text": [
"miRNA"
],
"offsets": [
[
826,
831
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d58.s5.e0"
}
]
},
{
"id": "2839",
"type": "Relation_Trigger",
"text": [
"up-regulated"
],
"offsets": [
[
810,
822
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d58.s5.e1"
}
]
},
{
"id": "2840",
"type": "Diseases",
"text": [
"motor neuron degeneration"
],
"offsets": [
[
768,
793
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d58.s5.e2"
}
]
},
{
"id": "2841",
"type": "Non-Specific_miRNAs",
"text": [
"miRNA"
],
"offsets": [
[
881,
886
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d58.s6.e0"
}
]
},
{
"id": "2842",
"type": "Specific_miRNAs",
"text": [
"miR-9"
],
"offsets": [
[
948,
953
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d58.s6.e1"
}
]
},
{
"id": "2843",
"type": "Diseases",
"text": [
"SMN diseases"
],
"offsets": [
[
899,
911
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d58.s6.e2"
}
]
},
{
"id": "2844",
"type": "Relation_Trigger",
"text": [
"regulatory"
],
"offsets": [
[
960,
970
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d58.s6.e3"
}
]
}
] | [] | [] | [
{
"id": "2845",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d58.s1.e0",
"arg2_id": "miRNA-corp.d58.s1.e1",
"normalized": []
},
{
"id": "2846",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d58.s2.e2",
"arg2_id": "miRNA-corp.d58.s2.e0",
"normalized": []
},
{
"id": "2847",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d58.s2.e2",
"arg2_id": "miRNA-corp.d58.s2.e1",
"normalized": []
},
{
"id": "2848",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d58.s2.e2",
"arg2_id": "miRNA-corp.d58.s2.e3",
"normalized": []
},
{
"id": "2849",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d58.s2.e2",
"arg2_id": "miRNA-corp.d58.s2.e4",
"normalized": []
},
{
"id": "2850",
"type": "Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d58.s4.e0",
"arg2_id": "miRNA-corp.d58.s4.e1",
"normalized": []
},
{
"id": "2851",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d58.s4.e2",
"arg2_id": "miRNA-corp.d58.s4.e1",
"normalized": []
},
{
"id": "2852",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d58.s5.e0",
"arg2_id": "miRNA-corp.d58.s5.e2",
"normalized": []
},
{
"id": "2853",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d58.s6.e0",
"arg2_id": "miRNA-corp.d58.s6.e2",
"normalized": []
},
{
"id": "2854",
"type": "Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d58.s6.e1",
"arg2_id": "miRNA-corp.d58.s6.e2",
"normalized": []
}
] |
2896 | miRNA-corp.d59 | [
{
"id": "2856",
"type": "title",
"text": [
"Novel animal models for studying complex brain disorders: BAC-driven miRNA-mediated in vivo silencing of gene expression. "
],
"offsets": [
[
0,
123
]
]
},
{
"id": "2857",
"type": "abstract",
"text": [
"In schizophrenia, glutamic acid decarboxylase 1 (GAD1) disturbances are robust, consistently observed, cell-type specific and represent a core feature of the disease. "
],
"offsets": [
[
124,
291
]
]
},
{
"id": "2858",
"type": "abstract",
"text": [
"In addition, neuropeptide Y (NPY), which is a phenotypic marker of a sub-population of GAD1-containing interneurons, has shown reduced expression in the prefrontal cortex in subjects with schizophrenia, suggesting that dysfunction of the NPY+ cortical interneuronal sub-population might be a core feature of this devastating disorder. "
],
"offsets": [
[
292,
627
]
]
},
{
"id": "2859",
"type": "abstract",
"text": [
"However, modeling gene expression disturbances in schizophrenia in a cell type-specific manner has been extremely challenging. "
],
"offsets": [
[
628,
755
]
]
},
{
"id": "2860",
"type": "abstract",
"text": [
"To more closely mimic these molecular and cellular human post-mortem findings, we generated a transgenic mouse in which we downregulated GAD1 mRNA expression specifically in NPY+ neurons. "
],
"offsets": [
[
756,
944
]
]
},
{
"id": "2861",
"type": "abstract",
"text": [
"This novel, cell type-specific in vivo system for reducing gene expression uses a bacterial artificial chromosome (BAC) containing the NPY promoter-enhancer elements, the reporter molecule (eGFP) and a modified intron containing a synthetic microRNA (miRNA) targeted to GAD1. "
],
"offsets": [
[
945,
1221
]
]
},
{
"id": "2862",
"type": "abstract",
"text": [
"The animals of isogenic strains are generated rapidly, providing a new tool for better understanding the molecular disturbances in the GABAergic system observed in complex neuropsychiatric disorders such as schizophrenia. "
],
"offsets": [
[
1222,
1444
]
]
},
{
"id": "2863",
"type": "abstract",
"text": [
"In the future, because of the small size of the silencing miRNAs combined with our BAC strategy, this method may be modified to allow generation of mice with simultaneous silencing of multiple genes in the same cells with a single construct, and production of splice-variant-specific knockdown animals. "
],
"offsets": [
[
1445,
1750
]
]
}
] | [
{
"id": "2864",
"type": "Diseases",
"text": [
"brain disorders"
],
"offsets": [
[
41,
56
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d59.s0.e0"
}
]
},
{
"id": "2865",
"type": "Non-Specific_miRNAs",
"text": [
"miRNA"
],
"offsets": [
[
69,
74
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d59.s0.e1"
}
]
},
{
"id": "2866",
"type": "Diseases",
"text": [
"schizophrenia"
],
"offsets": [
[
127,
140
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d59.s1.e0"
}
]
},
{
"id": "2867",
"type": "Genes/Proteins",
"text": [
"glutamic acid decarboxylase 1"
],
"offsets": [
[
142,
171
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d59.s1.e1"
}
]
},
{
"id": "2868",
"type": "Genes/Proteins",
"text": [
"GAD1"
],
"offsets": [
[
173,
177
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d59.s1.e2"
}
]
},
{
"id": "2869",
"type": "Diseases",
"text": [
"schizophrenia"
],
"offsets": [
[
480,
493
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d59.s2.e0"
}
]
},
{
"id": "2870",
"type": "Genes/Proteins",
"text": [
"GAD1"
],
"offsets": [
[
379,
383
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d59.s2.e1"
}
]
},
{
"id": "2871",
"type": "Relation_Trigger",
"text": [
"reduced expression"
],
"offsets": [
[
419,
437
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d59.s2.e2"
}
]
},
{
"id": "2872",
"type": "Relation_Trigger",
"text": [
"dysfunction"
],
"offsets": [
[
511,
522
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d59.s2.e3"
}
]
},
{
"id": "2873",
"type": "Genes/Proteins",
"text": [
"neuropeptide Y"
],
"offsets": [
[
305,
319
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d59.s2.e4"
}
]
},
{
"id": "2874",
"type": "Genes/Proteins",
"text": [
"NPY"
],
"offsets": [
[
321,
324
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d59.s2.e5"
}
]
},
{
"id": "2875",
"type": "Diseases",
"text": [
"schizophrenia"
],
"offsets": [
[
678,
691
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d59.s3.e0"
}
]
},
{
"id": "2876",
"type": "Genes/Proteins",
"text": [
"GAD1"
],
"offsets": [
[
893,
897
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d59.s4.e0"
}
]
},
{
"id": "2877",
"type": "Relation_Trigger",
"text": [
"downregulated GAD1 mRNA expression"
],
"offsets": [
[
879,
913
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d59.s4.e1"
}
]
},
{
"id": "2878",
"type": "Genes/Proteins",
"text": [
"NPY"
],
"offsets": [
[
930,
933
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d59.s4.e2"
}
]
},
{
"id": "2879",
"type": "Species",
"text": [
"human"
],
"offsets": [
[
807,
812
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d59.s4.e3"
}
]
},
{
"id": "2880",
"type": "Species",
"text": [
"transgenic mouse"
],
"offsets": [
[
850,
866
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d59.s4.e4"
}
]
},
{
"id": "2881",
"type": "Non-Specific_miRNAs",
"text": [
"microRNA"
],
"offsets": [
[
1186,
1194
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d59.s5.e0"
}
]
},
{
"id": "2882",
"type": "Non-Specific_miRNAs",
"text": [
"miRNA"
],
"offsets": [
[
1196,
1201
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d59.s5.e1"
}
]
},
{
"id": "2883",
"type": "Genes/Proteins",
"text": [
"GAD1"
],
"offsets": [
[
1215,
1219
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d59.s5.e2"
}
]
},
{
"id": "2884",
"type": "Relation_Trigger",
"text": [
"reducing gene expression"
],
"offsets": [
[
995,
1019
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d59.s5.e3"
}
]
},
{
"id": "2885",
"type": "Genes/Proteins",
"text": [
"NPY"
],
"offsets": [
[
1080,
1083
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d59.s5.e4"
}
]
},
{
"id": "2886",
"type": "Relation_Trigger",
"text": [
"targeted"
],
"offsets": [
[
1203,
1211
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d59.s5.e5"
}
]
},
{
"id": "2887",
"type": "Diseases",
"text": [
"neuropsychiatric disorders"
],
"offsets": [
[
1394,
1420
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d59.s6.e0"
}
]
},
{
"id": "2888",
"type": "Diseases",
"text": [
"schizophrenia"
],
"offsets": [
[
1429,
1442
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d59.s6.e1"
}
]
},
{
"id": "2889",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
[
1503,
1509
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d59.s7.e0"
}
]
},
{
"id": "2890",
"type": "Species",
"text": [
"mice"
],
"offsets": [
[
1593,
1597
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d59.s7.e1"
}
]
}
] | [] | [] | [
{
"id": "2891",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d59.s0.e1",
"arg2_id": "miRNA-corp.d59.s0.e0",
"normalized": []
},
{
"id": "2892",
"type": "Non-Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d59.s5.e0",
"arg2_id": "miRNA-corp.d59.s5.e2",
"normalized": []
},
{
"id": "2893",
"type": "Non-Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d59.s5.e0",
"arg2_id": "miRNA-corp.d59.s5.e4",
"normalized": []
},
{
"id": "2894",
"type": "Non-Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d59.s5.e1",
"arg2_id": "miRNA-corp.d59.s5.e2",
"normalized": []
},
{
"id": "2895",
"type": "Non-Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d59.s5.e1",
"arg2_id": "miRNA-corp.d59.s5.e4",
"normalized": []
}
] |
2954 | miRNA-corp.d60 | [
{
"id": "2897",
"type": "title",
"text": [
"Through various experimental approaches, we validated computational predictions and demonstrated that miR-298 and miR-328 recognize specific binding sites in the 3'-UTR of BACE1 mRNA and exert regulatory effects on BACE1 protein expression in cultured neuronal cells. "
],
"offsets": [
[
0,
268
]
]
},
{
"id": "2898",
"type": "abstract",
"text": [
"Here we also observed a loss of correlation between BACE1 mRNA and protein levels in the hippocampus of a mouse model of AD. Consistent with an impairment of miRNA-mediated regulation of BACE1 expression, these findings prompted us to investigate the regulatory role of the BACE1 3'-UTR element and the possible involvement of specific miRNAs in cultured neuronal (N2a) and fibroblastic (NIH 3T3) cells. "
],
"offsets": [
[
269,
673
]
]
},
{
"id": "2899",
"type": "abstract",
"text": [
"Our results may provide the molecular basis underlying BACE1 deregulation in AD and offer new perspectives on the etiology of this neurological disorder. "
],
"offsets": [
[
674,
830
]
]
},
{
"id": "2900",
"type": "abstract",
"text": [
"MicroRNAs (miRNAs) are key regulatory RNAs known to repress mRNA translation through recognition of specific binding sites located mainly in their 3'-untranslated region (UTR). "
],
"offsets": [
[
831,
1008
]
]
},
{
"id": "2901",
"type": "abstract",
"text": [
"MicroRNA-298 and microRNA-328 regulate expression of mouse beta-amyloid precursor protein-converting enzyme 1. "
],
"offsets": [
[
1009,
1121
]
]
},
{
"id": "2902",
"type": "abstract",
"text": [
"Intriguingly, previous post-mortem analyses showed higher beta-amyloid precursor protein-converting enzyme (BACE) protein, but not mRNA, levels in the brain of patients that suffered from Alzheimer disease (AD). "
],
"offsets": [
[
1122,
1334
]
]
},
{
"id": "2903",
"type": "abstract",
"text": [
"Loss of specific miRNA control of gene expression is thus expected to underlie serious genetic diseases. "
],
"offsets": [
[
1335,
1440
]
]
}
] | [
{
"id": "2904",
"type": "Genes/Proteins",
"text": [
"BACE1"
],
"offsets": [
[
215,
220
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d60.s0.e0"
}
]
},
{
"id": "2905",
"type": "Specific_miRNAs",
"text": [
"miR-328"
],
"offsets": [
[
114,
121
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d60.s0.e1"
}
]
},
{
"id": "2906",
"type": "Genes/Proteins",
"text": [
"BACE1"
],
"offsets": [
[
172,
177
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d60.s0.e2"
}
]
},
{
"id": "2907",
"type": "Specific_miRNAs",
"text": [
"miR-298"
],
"offsets": [
[
102,
109
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d60.s0.e3"
}
]
},
{
"id": "2908",
"type": "Relation_Trigger",
"text": [
"regulatory effects on BACE1 protein expression"
],
"offsets": [
[
193,
239
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d60.s0.e4"
}
]
},
{
"id": "2909",
"type": "Relation_Trigger",
"text": [
"recognize specific binding sites in the 3'-UTR"
],
"offsets": [
[
122,
168
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d60.s0.e5"
}
]
},
{
"id": "2910",
"type": "Diseases",
"text": [
"AD"
],
"offsets": [
[
390,
392
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d60.s1.e0"
}
]
},
{
"id": "2911",
"type": "Genes/Proteins",
"text": [
"BACE1"
],
"offsets": [
[
543,
548
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d60.s1.e1"
}
]
},
{
"id": "2912",
"type": "Non-Specific_miRNAs",
"text": [
"miRNA"
],
"offsets": [
[
427,
432
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d60.s1.e2"
}
]
},
{
"id": "2913",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
[
605,
611
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d60.s1.e3"
}
]
},
{
"id": "2914",
"type": "Relation_Trigger",
"text": [
"loss of correlation"
],
"offsets": [
[
293,
312
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d60.s1.e4"
}
]
},
{
"id": "2915",
"type": "Relation_Trigger",
"text": [
"regulation of BACE1 expression"
],
"offsets": [
[
442,
472
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d60.s1.e5"
}
]
},
{
"id": "2916",
"type": "Relation_Trigger",
"text": [
"regulatory"
],
"offsets": [
[
520,
530
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d60.s1.e6"
}
]
},
{
"id": "2917",
"type": "Genes/Proteins",
"text": [
"BACE1"
],
"offsets": [
[
456,
461
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d60.s1.e7"
}
]
},
{
"id": "2918",
"type": "Genes/Proteins",
"text": [
"BACE1"
],
"offsets": [
[
321,
326
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d60.s1.e8"
}
]
},
{
"id": "2919",
"type": "Relation_Trigger",
"text": [
"impairment"
],
"offsets": [
[
413,
423
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d60.s1.e9"
}
]
},
{
"id": "2920",
"type": "Species",
"text": [
"mouse"
],
"offsets": [
[
375,
380
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d60.s1.e10"
}
]
},
{
"id": "2921",
"type": "Diseases",
"text": [
"AD"
],
"offsets": [
[
751,
753
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d60.s2.e0"
}
]
},
{
"id": "2922",
"type": "Genes/Proteins",
"text": [
"BACE1"
],
"offsets": [
[
729,
734
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d60.s2.e1"
}
]
},
{
"id": "2923",
"type": "Relation_Trigger",
"text": [
"deregulation"
],
"offsets": [
[
735,
747
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d60.s2.e2"
}
]
},
{
"id": "2924",
"type": "Diseases",
"text": [
"neurological disorder"
],
"offsets": [
[
805,
826
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d60.s2.e3"
}
]
},
{
"id": "2925",
"type": "Non-Specific_miRNAs",
"text": [
"MicroRNAs"
],
"offsets": [
[
831,
840
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d60.s3.e0"
}
]
},
{
"id": "2926",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
[
842,
848
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d60.s3.e1"
}
]
},
{
"id": "2927",
"type": "Relation_Trigger",
"text": [
"repress mRNA translation"
],
"offsets": [
[
883,
907
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d60.s3.e2"
}
]
},
{
"id": "2928",
"type": "Relation_Trigger",
"text": [
"regulatory"
],
"offsets": [
[
858,
868
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d60.s3.e3"
}
]
},
{
"id": "2929",
"type": "Relation_Trigger",
"text": [
"binding sites"
],
"offsets": [
[
940,
953
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d60.s3.e4"
}
]
},
{
"id": "2930",
"type": "Specific_miRNAs",
"text": [
"MicroRNA-298"
],
"offsets": [
[
1009,
1021
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d60.s4.e0"
}
]
},
{
"id": "2931",
"type": "Specific_miRNAs",
"text": [
"microRNA-328"
],
"offsets": [
[
1026,
1038
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d60.s4.e1"
}
]
},
{
"id": "2932",
"type": "Relation_Trigger",
"text": [
"regulate expression"
],
"offsets": [
[
1039,
1058
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d60.s4.e2"
}
]
},
{
"id": "2933",
"type": "Species",
"text": [
"mouse"
],
"offsets": [
[
1062,
1067
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d60.s4.e3"
}
]
},
{
"id": "2934",
"type": "Diseases",
"text": [
"Alzheimer disease"
],
"offsets": [
[
1310,
1327
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d60.s5.e0"
}
]
},
{
"id": "2935",
"type": "Diseases",
"text": [
"AD"
],
"offsets": [
[
1329,
1331
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d60.s5.e1"
}
]
},
{
"id": "2936",
"type": "Relation_Trigger",
"text": [
"higher beta-amyloid precursor protein-converting enzyme (BACE) protein"
],
"offsets": [
[
1173,
1243
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d60.s5.e2"
}
]
},
{
"id": "2937",
"type": "Genes/Proteins",
"text": [
"beta-amyloid precursor protein-converting enzyme (BACE) protein"
],
"offsets": [
[
1180,
1243
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d60.s5.e3"
}
]
},
{
"id": "2938",
"type": "Genes/Proteins",
"text": [
"BACE"
],
"offsets": [
[
1230,
1234
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d60.s5.e4"
}
]
},
{
"id": "2939",
"type": "Species",
"text": [
"patients"
],
"offsets": [
[
1282,
1290
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d60.s5.e5"
}
]
},
{
"id": "2940",
"type": "Non-Specific_miRNAs",
"text": [
"miRNA"
],
"offsets": [
[
1352,
1357
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d60.s6.e0"
}
]
},
{
"id": "2941",
"type": "Relation_Trigger",
"text": [
"Loss of specific miRNA"
],
"offsets": [
[
1335,
1357
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d60.s6.e1"
}
]
}
] | [] | [] | [
{
"id": "2942",
"type": "Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d60.s0.e1",
"arg2_id": "miRNA-corp.d60.s0.e0",
"normalized": []
},
{
"id": "2943",
"type": "Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d60.s0.e1",
"arg2_id": "miRNA-corp.d60.s0.e2",
"normalized": []
},
{
"id": "2944",
"type": "Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d60.s0.e3",
"arg2_id": "miRNA-corp.d60.s0.e0",
"normalized": []
},
{
"id": "2945",
"type": "Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d60.s0.e3",
"arg2_id": "miRNA-corp.d60.s0.e2",
"normalized": []
},
{
"id": "2946",
"type": "Non-Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d60.s1.e2",
"arg2_id": "miRNA-corp.d60.s1.e1",
"normalized": []
},
{
"id": "2947",
"type": "Non-Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d60.s1.e2",
"arg2_id": "miRNA-corp.d60.s1.e7",
"normalized": []
},
{
"id": "2948",
"type": "Non-Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d60.s1.e2",
"arg2_id": "miRNA-corp.d60.s1.e8",
"normalized": []
},
{
"id": "2949",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d60.s1.e2",
"arg2_id": "miRNA-corp.d60.s1.e0",
"normalized": []
},
{
"id": "2950",
"type": "Non-Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d60.s1.e3",
"arg2_id": "miRNA-corp.d60.s1.e1",
"normalized": []
},
{
"id": "2951",
"type": "Non-Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d60.s1.e3",
"arg2_id": "miRNA-corp.d60.s1.e7",
"normalized": []
},
{
"id": "2952",
"type": "Non-Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d60.s1.e3",
"arg2_id": "miRNA-corp.d60.s1.e8",
"normalized": []
},
{
"id": "2953",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d60.s1.e3",
"arg2_id": "miRNA-corp.d60.s1.e0",
"normalized": []
}
] |
3058 | miRNA-corp.d61 | [
{
"id": "2955",
"type": "title",
"text": [
"MiRNAs microarray analysis results showed that 125 miRNAs were detected in the hippocampus of lithium-pilocarpine-induced TLE rats and normal rats. "
],
"offsets": [
[
0,
148
]
]
},
{
"id": "2956",
"type": "abstract",
"text": [
"To understand the role of miRNAs in the molecular mechanisms of temporal lobe epilepsy (TLE), we investigated the changes in microRNA (miRNA) expression profiles of chronic TLE rat models. "
],
"offsets": [
[
149,
338
]
]
},
{
"id": "2957",
"type": "abstract",
"text": [
"Temporal lobe epilepsy induces differential expression of hippocampal miRNAs including let-7e and miR-23a/b. "
],
"offsets": [
[
339,
449
]
]
},
{
"id": "2958",
"type": "abstract",
"text": [
"let-7e was detected down-regulated expression at 0h, 1h, 6h, 2days, 7days, 50days after SE and up-regulated expression at 12h, 24h, 10days, 30days after SE, which was significantly up-regulated expression at 24h after SE (10.49 folds, P<0.01). "
],
"offsets": [
[
450,
694
]
]
},
{
"id": "2959",
"type": "abstract",
"text": [
"miR-23a/b was detected down-regulated at 0h, 1h, 6h, 12h, 2days, 7days, 10days, 30days after SE and significantly up-regulated at 24h (4.49 folds P<0.01), 50d (2.4 folds, P<0.01) after SE. TLE alters the expression levels of a subset of miRNAs in the hippocampus and these deregulated miRNAs may be involved in the pathogenesis of epilepsy directly or indirectly. "
],
"offsets": [
[
695,
1059
]
]
},
{
"id": "2960",
"type": "abstract",
"text": [
"Compared with normal rats (control group), 23 of the 125 miRNAs were expressed differentially in TLE rats including 5 down-regulated miRNAs (let-7e included) and 18 up-regulated miRNAs (miR-23a/b included). "
],
"offsets": [
[
1060,
1267
]
]
},
{
"id": "2961",
"type": "abstract",
"text": [
"Furthermore, let-7e and miR-23a/b analysis in rat hippocampus were performed by real-time quantitative polymerase chain reaction at 0h, 1h, 6h, 12h, 24h, 2days, 7days,10days, 30days,50days after induction of status epilepticus (SE). "
],
"offsets": [
[
1268,
1501
]
]
},
{
"id": "2962",
"type": "abstract",
"text": [
"Also the temporal change of the let-7e and miR-23a/b expression in the epileptogenesis indicated their underlying functions on TLE. "
],
"offsets": [
[
1502,
1636
]
]
}
] | [
{
"id": "2963",
"type": "Non-Specific_miRNAs",
"text": [
"MiRNAs"
],
"offsets": [
[
0,
6
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d61.s0.e0"
}
]
},
{
"id": "2964",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
[
51,
57
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d61.s0.e1"
}
]
},
{
"id": "2965",
"type": "Diseases",
"text": [
"TLE"
],
"offsets": [
[
122,
125
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d61.s0.e2"
}
]
},
{
"id": "2966",
"type": "Species",
"text": [
"rats"
],
"offsets": [
[
126,
130
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d61.s0.e3"
}
]
},
{
"id": "2967",
"type": "Species",
"text": [
"rats"
],
"offsets": [
[
142,
146
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d61.s0.e4"
}
]
},
{
"id": "2968",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
[
175,
181
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d61.s1.e0"
}
]
},
{
"id": "2969",
"type": "Non-Specific_miRNAs",
"text": [
"microRNA"
],
"offsets": [
[
274,
282
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d61.s1.e1"
}
]
},
{
"id": "2970",
"type": "Non-Specific_miRNAs",
"text": [
"miRNA"
],
"offsets": [
[
284,
289
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d61.s1.e2"
}
]
},
{
"id": "2971",
"type": "Diseases",
"text": [
"temporal lobe epilepsy"
],
"offsets": [
[
213,
235
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d61.s1.e3"
}
]
},
{
"id": "2972",
"type": "Diseases",
"text": [
"TLE"
],
"offsets": [
[
237,
240
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d61.s1.e4"
}
]
},
{
"id": "2973",
"type": "Diseases",
"text": [
"TLE"
],
"offsets": [
[
322,
325
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d61.s1.e5"
}
]
},
{
"id": "2974",
"type": "Species",
"text": [
"rat"
],
"offsets": [
[
326,
329
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d61.s1.e6"
}
]
},
{
"id": "2975",
"type": "Specific_miRNAs",
"text": [
"miR-23a/b"
],
"offsets": [
[
437,
446
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d61.s2.e0"
}
]
},
{
"id": "2976",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
[
409,
415
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d61.s2.e1"
}
]
},
{
"id": "2977",
"type": "Diseases",
"text": [
"Temporal lobe epilepsy"
],
"offsets": [
[
339,
361
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d61.s2.e2"
}
]
},
{
"id": "2978",
"type": "Specific_miRNAs",
"text": [
"let-7e"
],
"offsets": [
[
426,
432
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d61.s2.e3"
}
]
},
{
"id": "2979",
"type": "Relation_Trigger",
"text": [
"induces differential expression"
],
"offsets": [
[
362,
393
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d61.s2.e4"
}
]
},
{
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"id": "3007",
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},
{
"id": "3010",
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{
"id": "3011",
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]
},
{
"id": "3012",
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]
},
{
"id": "3013",
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"id": "3016",
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},
{
"id": "3017",
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]
}
] | [] | [] | [
{
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{
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{
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{
"id": "3028",
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{
"id": "3029",
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{
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{
"id": "3031",
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{
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{
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{
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{
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{
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{
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{
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{
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{
"id": "3043",
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{
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{
"id": "3045",
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{
"id": "3046",
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},
{
"id": "3047",
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},
{
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"type": "Non-Specific_miRNAs-Diseases",
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{
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{
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{
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{
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"arg2_id": "miRNA-corp.d61.s7.e2",
"normalized": []
}
] |
3069 | miRNA-corp.d62 | [
{
"id": "3059",
"type": "abstract",
"text": [
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],
"offsets": [
[
0,
114
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]
},
{
"id": "3060",
"type": "abstract",
"text": [
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],
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[
115,
229
]
]
},
{
"id": "3061",
"type": "abstract",
"text": [
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],
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[
230,
333
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]
},
{
"id": "3062",
"type": "abstract",
"text": [
"We mainly introduced the recent progress of scrAAV based therapy of Hemophilia B, in order to elucidate the potential and prospects of scrAAV in gene therapy. "
],
"offsets": [
[
334,
495
]
]
}
] | [
{
"id": "3063",
"type": "Relation_Trigger",
"text": [
"increase expression"
],
"offsets": [
[
26,
45
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d62.s5.e0"
}
]
},
{
"id": "3064",
"type": "Diseases",
"text": [
"central nervous system diseases"
],
"offsets": [
[
178,
209
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d62.s7.e0"
}
]
},
{
"id": "3065",
"type": "Diseases",
"text": [
"hepatic diseases"
],
"offsets": [
[
160,
176
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d62.s7.e1"
}
]
},
{
"id": "3066",
"type": "Diseases",
"text": [
"eye diseases"
],
"offsets": [
[
215,
227
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d62.s7.e2"
}
]
},
{
"id": "3067",
"type": "Non-Specific_miRNAs",
"text": [
"miRNA"
],
"offsets": [
[
312,
317
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d62.s8.e0"
}
]
},
{
"id": "3068",
"type": "Diseases",
"text": [
"Hemophilia B"
],
"offsets": [
[
402,
414
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d62.s10.e0"
}
]
}
] | [] | [] | [] |
3084 | miRNA-corp.d63 | [
{
"id": "3070",
"type": "title",
"text": [
"Learning, retention and generalization of a mirror tracing skill in Alzheimer's disease. "
],
"offsets": [
[
0,
90
]
]
},
{
"id": "3071",
"type": "abstract",
"text": [
"The present study examined the ability of 12 patients with probable Alzheimer's disease (AD) and 12 age- and education-matched normal control (NC) subjects to learn and retain the visuomotor skills necessary to efficiently trace a pattern (e.g., a 4- or 6-pointed star) seen only in mirror-reversed view. "
],
"offsets": [
[
91,
396
]
]
},
{
"id": "3072",
"type": "abstract",
"text": [
"Those AD (N=6) and NC (N=7) subjects who were able to initially perform the basic mirror tracing task did not differ significantly in initial level of performance, learning over trials, retention of the skill over a 30-min delay interval, and generalization of the skill to a new figure or to the opposite direction of tracing. "
],
"offsets": [
[
397,
725
]
]
},
{
"id": "3073",
"type": "abstract",
"text": [
"The AD patients who were unable to initially perform the mirror tracing task were significantly worse than those who could perform the task on several neuropsychological measures sensitive to deficits in problem solving and executive functions, but not on tests of global cognitive decline, memory, language, or visuoperceptual functioning. "
],
"offsets": [
[
726,
1067
]
]
},
{
"id": "3074",
"type": "abstract",
"text": [
"These results indicate that acquisition and retention of a complex visuomotor skill can proceed normally in the early stages of AD in those individuals who can initially perform the basic task, and that inability to perform the basic task may be related to the frontal lobe dysfunction that is often prominent in the disorder. "
],
"offsets": [
[
1068,
1397
]
]
}
] | [
{
"id": "3075",
"type": "Diseases",
"text": [
"Alzheimer's disease"
],
"offsets": [
[
68,
87
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d63.s0.e0"
}
]
},
{
"id": "3076",
"type": "Diseases",
"text": [
"Alzheimer's disease"
],
"offsets": [
[
159,
178
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d63.s1.e0"
}
]
},
{
"id": "3077",
"type": "Diseases",
"text": [
"AD"
],
"offsets": [
[
180,
182
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d63.s1.e1"
}
]
},
{
"id": "3078",
"type": "Species",
"text": [
"patients"
],
"offsets": [
[
136,
144
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d63.s1.e2"
}
]
},
{
"id": "3079",
"type": "Diseases",
"text": [
"AD"
],
"offsets": [
[
403,
405
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d63.s2.e0"
}
]
},
{
"id": "3080",
"type": "Diseases",
"text": [
"AD"
],
"offsets": [
[
730,
732
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d63.s3.e0"
}
]
},
{
"id": "3081",
"type": "Species",
"text": [
"patients"
],
"offsets": [
[
733,
741
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d63.s3.e1"
}
]
},
{
"id": "3082",
"type": "Diseases",
"text": [
"frontal lobe dysfunction"
],
"offsets": [
[
1329,
1353
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d63.s4.e0"
}
]
},
{
"id": "3083",
"type": "Diseases",
"text": [
"AD"
],
"offsets": [
[
1196,
1198
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d63.s4.e1"
}
]
}
] | [] | [] | [] |
3101 | miRNA-corp.d64 | [
{
"id": "3085",
"type": "title",
"text": [
"This review reports the current knowledge of microRNA (miRNA) expression in pituitary adenomas, focusing on recent microarray data. "
],
"offsets": [
[
0,
132
]
]
},
{
"id": "3086",
"type": "abstract",
"text": [
"Moreover, a discussion is provided concerning the possible role of validated and putative targets of the most dysregulated miRNA in pituitary adenoma pathogenesis. "
],
"offsets": [
[
133,
299
]
]
},
{
"id": "3087",
"type": "abstract",
"text": [
"MicroRNAs and possible role in pituitary adenoma. "
],
"offsets": [
[
300,
351
]
]
}
] | [
{
"id": "3088",
"type": "Non-Specific_miRNAs",
"text": [
"microRNA"
],
"offsets": [
[
45,
53
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d64.s0.e0"
}
]
},
{
"id": "3089",
"type": "Non-Specific_miRNAs",
"text": [
"miRNA"
],
"offsets": [
[
55,
60
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d64.s0.e1"
}
]
},
{
"id": "3090",
"type": "Diseases",
"text": [
"pituitary adenomas"
],
"offsets": [
[
76,
94
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d64.s0.e2"
}
]
},
{
"id": "3091",
"type": "Non-Specific_miRNAs",
"text": [
"miRNA"
],
"offsets": [
[
256,
261
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d64.s1.e0"
}
]
},
{
"id": "3092",
"type": "Diseases",
"text": [
"pituitary adenoma"
],
"offsets": [
[
265,
282
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d64.s1.e1"
}
]
},
{
"id": "3093",
"type": "Relation_Trigger",
"text": [
"dysregulated"
],
"offsets": [
[
243,
255
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d64.s1.e2"
}
]
},
{
"id": "3094",
"type": "Relation_Trigger",
"text": [
"putative targets"
],
"offsets": [
[
214,
230
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d64.s1.e3"
}
]
},
{
"id": "3095",
"type": "Non-Specific_miRNAs",
"text": [
"MicroRNAs"
],
"offsets": [
[
300,
309
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d64.s2.e0"
}
]
},
{
"id": "3096",
"type": "Diseases",
"text": [
"pituitary adenoma"
],
"offsets": [
[
331,
348
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d64.s2.e1"
}
]
}
] | [] | [] | [
{
"id": "3097",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d64.s0.e0",
"arg2_id": "miRNA-corp.d64.s0.e2",
"normalized": []
},
{
"id": "3098",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d64.s0.e1",
"arg2_id": "miRNA-corp.d64.s0.e2",
"normalized": []
},
{
"id": "3099",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d64.s1.e0",
"arg2_id": "miRNA-corp.d64.s1.e1",
"normalized": []
},
{
"id": "3100",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d64.s2.e0",
"arg2_id": "miRNA-corp.d64.s2.e1",
"normalized": []
}
] |
3148 | miRNA-corp.d65 | [
{
"id": "3102",
"type": "title",
"text": [
"Expression profile of MicroRNAs in young stroke patients. "
],
"offsets": [
[
0,
59
]
]
},
{
"id": "3103",
"type": "abstract",
"text": [
"BACKGROUND: The methods currently available for diagnosis and prognosis of cerebral ischaemia still require further improvements. "
],
"offsets": [
[
60,
190
]
]
},
{
"id": "3104",
"type": "abstract",
"text": [
"Total RNA extracted from whole blood was subjected to miroRNA profiling and real-time PCR analysis. "
],
"offsets": [
[
191,
291
]
]
},
{
"id": "3105",
"type": "abstract",
"text": [
"miRNAs that are implicated in the endothelial/vascular function, erythropoiesis, angiogenesis and neural function showed differential expression profile as compared to the normal control. "
],
"offsets": [
[
292,
480
]
]
},
{
"id": "3106",
"type": "abstract",
"text": [
"Interestingly, miRNAs that are involved in hypoxic conditions have also been found in our miRNA profiles. "
],
"offsets": [
[
481,
587
]
]
},
{
"id": "3107",
"type": "abstract",
"text": [
"Micro-RNAs (small non-coding RNAs) have been recently reported as useful biomarkers in diseases such as cancer and diabetes. "
],
"offsets": [
[
588,
713
]
]
},
{
"id": "3108",
"type": "abstract",
"text": [
"We therefore carried out microRNA (miRNA) profiling from peripheral blood to detect and identify characteristic patterns in ischaemic stroke. "
],
"offsets": [
[
714,
856
]
]
},
{
"id": "3109",
"type": "abstract",
"text": [
"METHODS/PRINCIPAL FINDINGS: The ischaemic stroke patients aged between 18-49 years, characterized based on World Health Organization clinical criteria were further classified according to TOAST classification, a) Large-vessel atherosclerosis [n=8] b) Small-vessel disease [n=3] c) Cardioembolism [n=5] d) Undetermined cause [n=3]. "
],
"offsets": [
[
857,
1188
]
]
},
{
"id": "3110",
"type": "abstract",
"text": [
"The patients' functional status at the time of blood sampling (at the outpatient clinics) was evaluated with the modified Rankin Scale (mRS). "
],
"offsets": [
[
1189,
1331
]
]
},
{
"id": "3111",
"type": "abstract",
"text": [
"CONCLUSION: We demonstrate that the peripheral blood miRNAs and their profiles can be developed as biomarkers in diagnosis and prognosis of cerebral ischaemic stroke. "
],
"offsets": [
[
1332,
1499
]
]
},
{
"id": "3112",
"type": "abstract",
"text": [
"The dysregulated miRNAs have been detectable even after several months from the onset of stroke in what is usually regarded as neurologically stable patients. "
],
"offsets": [
[
1500,
1661
]
]
}
] | [
{
"id": "3113",
"type": "Non-Specific_miRNAs",
"text": [
"MicroRNAs"
],
"offsets": [
[
22,
31
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d65.s0.e0"
}
]
},
{
"id": "3114",
"type": "Diseases",
"text": [
"stroke"
],
"offsets": [
[
41,
47
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d65.s0.e1"
}
]
},
{
"id": "3115",
"type": "Species",
"text": [
"patients"
],
"offsets": [
[
48,
56
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d65.s0.e2"
}
]
},
{
"id": "3116",
"type": "Diseases",
"text": [
"cerebral ischaemia"
],
"offsets": [
[
135,
153
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d65.s1.e0"
}
]
},
{
"id": "3117",
"type": "Non-Specific_miRNAs",
"text": [
"miroRNA"
],
"offsets": [
[
245,
252
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d65.s3.e0"
}
]
},
{
"id": "3118",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
[
292,
298
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d65.s4.e0"
}
]
},
{
"id": "3119",
"type": "Relation_Trigger",
"text": [
"differential expression"
],
"offsets": [
[
413,
436
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d65.s4.e1"
}
]
},
{
"id": "3120",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
[
496,
502
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d65.s5.e0"
}
]
},
{
"id": "3121",
"type": "Non-Specific_miRNAs",
"text": [
"miRNA"
],
"offsets": [
[
571,
576
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d65.s5.e1"
}
]
},
{
"id": "3122",
"type": "Diseases",
"text": [
"hypoxic"
],
"offsets": [
[
524,
531
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d65.s5.e2"
}
]
},
{
"id": "3123",
"type": "Non-Specific_miRNAs",
"text": [
"Micro-RNAs"
],
"offsets": [
[
588,
598
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d65.s6.e0"
}
]
},
{
"id": "3124",
"type": "Diseases",
"text": [
"diabetes"
],
"offsets": [
[
703,
711
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d65.s6.e1"
}
]
},
{
"id": "3125",
"type": "Diseases",
"text": [
"cancer"
],
"offsets": [
[
692,
698
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d65.s6.e2"
}
]
},
{
"id": "3126",
"type": "Non-Specific_miRNAs",
"text": [
"microRNA"
],
"offsets": [
[
739,
747
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d65.s7.e0"
}
]
},
{
"id": "3127",
"type": "Non-Specific_miRNAs",
"text": [
"miRNA"
],
"offsets": [
[
749,
754
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d65.s7.e1"
}
]
},
{
"id": "3128",
"type": "Diseases",
"text": [
"ischaemic stroke"
],
"offsets": [
[
838,
854
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d65.s7.e2"
}
]
},
{
"id": "3129",
"type": "Diseases",
"text": [
"ischaemic stroke"
],
"offsets": [
[
889,
905
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d65.s8.e0"
}
]
},
{
"id": "3130",
"type": "Diseases",
"text": [
"atherosclerosis"
],
"offsets": [
[
1083,
1098
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d65.s8.e1"
}
]
},
{
"id": "3131",
"type": "Species",
"text": [
"patients"
],
"offsets": [
[
906,
914
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d65.s8.e2"
}
]
},
{
"id": "3132",
"type": "Species",
"text": [
"patients"
],
"offsets": [
[
1193,
1201
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d65.s9.e0"
}
]
},
{
"id": "3133",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
[
1385,
1391
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d65.s10.e0"
}
]
},
{
"id": "3134",
"type": "Diseases",
"text": [
"cerebral ischaemic stroke"
],
"offsets": [
[
1472,
1497
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d65.s10.e1"
}
]
},
{
"id": "3135",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
[
1517,
1523
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d65.s11.e0"
}
]
},
{
"id": "3136",
"type": "Diseases",
"text": [
"stroke"
],
"offsets": [
[
1589,
1595
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d65.s11.e1"
}
]
},
{
"id": "3137",
"type": "Relation_Trigger",
"text": [
"dysregulated"
],
"offsets": [
[
1504,
1516
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d65.s11.e2"
}
]
},
{
"id": "3138",
"type": "Species",
"text": [
"patients"
],
"offsets": [
[
1649,
1657
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d65.s11.e3"
}
]
}
] | [] | [] | [
{
"id": "3139",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d65.s0.e0",
"arg2_id": "miRNA-corp.d65.s0.e1",
"normalized": []
},
{
"id": "3140",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d65.s5.e1",
"arg2_id": "miRNA-corp.d65.s5.e2",
"normalized": []
},
{
"id": "3141",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d65.s5.e0",
"arg2_id": "miRNA-corp.d65.s5.e2",
"normalized": []
},
{
"id": "3142",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d65.s6.e0",
"arg2_id": "miRNA-corp.d65.s6.e1",
"normalized": []
},
{
"id": "3143",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d65.s6.e0",
"arg2_id": "miRNA-corp.d65.s6.e2",
"normalized": []
},
{
"id": "3144",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d65.s7.e0",
"arg2_id": "miRNA-corp.d65.s7.e2",
"normalized": []
},
{
"id": "3145",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d65.s7.e1",
"arg2_id": "miRNA-corp.d65.s7.e2",
"normalized": []
},
{
"id": "3146",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d65.s10.e0",
"arg2_id": "miRNA-corp.d65.s10.e1",
"normalized": []
},
{
"id": "3147",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d65.s11.e0",
"arg2_id": "miRNA-corp.d65.s11.e1",
"normalized": []
}
] |
3199 | miRNA-corp.d66 | [
{
"id": "3149",
"type": "title",
"text": [
"We also indentified 97 differentially expressed microRNAs among 240 tumor and 10 normal samples. "
],
"offsets": [
[
0,
97
]
]
},
{
"id": "3150",
"type": "abstract",
"text": [
"22 of which have been reported to affect glioblastoma and 50 of which were implicated in other cancers and brain diseases. "
],
"offsets": [
[
98,
221
]
]
},
{
"id": "3151",
"type": "abstract",
"text": [
"Though a lot of research has been focused on this disease, the causes and pathogenesis of glioblastoma have not been indentified clearly. "
],
"offsets": [
[
222,
360
]
]
},
{
"id": "3152",
"type": "abstract",
"text": [
"RESULTS: We indentified 1,236 significantly differentially expressed genes, and 30 pathways enriched in the set of differentially expressed genes among 243 tumor and 11 normal samples. "
],
"offsets": [
[
361,
546
]
]
},
{
"id": "3153",
"type": "abstract",
"text": [
"Investigation gene and microRNA expression in glioblastoma. "
],
"offsets": [
[
547,
608
]
]
},
{
"id": "3154",
"type": "abstract",
"text": [
"BACKGROUND: Glioblastoma is the most common primary brain tumor in adults. "
],
"offsets": [
[
609,
684
]
]
},
{
"id": "3155",
"type": "abstract",
"text": [
"CONCLUSION: We investigated gene and microRNA Expression in Glioblastoma and gave a comprehensive function study of differential expressed gene and microRNA in glioblastoma patients. "
],
"offsets": [
[
685,
868
]
]
},
{
"id": "3156",
"type": "abstract",
"text": [
"Further function analysis of target genes suggested that microRNAs most frequently targeted genes associated with Cell Signalling and Nervous System. "
],
"offsets": [
[
869,
1019
]
]
},
{
"id": "3157",
"type": "abstract",
"text": [
"We found two experimentally validated microRNA targets and 1,094 miRNA-target gene pairs in our datasets which were predicted by miRanda algorithm, 8 of the target genes were tumor suppressor genes and 3 were oncogenes. "
],
"offsets": [
[
1020,
1240
]
]
},
{
"id": "3158",
"type": "abstract",
"text": [
"We regressed gene expression on microRNA expression in 237 tumor tissues and 10 normal tissues comprehensively. "
],
"offsets": [
[
1241,
1353
]
]
},
{
"id": "3159",
"type": "abstract",
"text": [
"These findings gave important clues to study of the carcinogenic process in glioblastomas. "
],
"offsets": [
[
1354,
1447
]
]
}
] | [
{
"id": "3160",
"type": "Non-Specific_miRNAs",
"text": [
"microRNAs"
],
"offsets": [
[
48,
57
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d66.s0.e0"
}
]
},
{
"id": "3161",
"type": "Relation_Trigger",
"text": [
"differentially expressed"
],
"offsets": [
[
23,
47
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d66.s0.e1"
}
]
},
{
"id": "3162",
"type": "Diseases",
"text": [
"tumor"
],
"offsets": [
[
68,
73
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d66.s0.e2"
}
]
},
{
"id": "3163",
"type": "Diseases",
"text": [
"glioblastoma"
],
"offsets": [
[
139,
151
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d66.s1.e0"
}
]
},
{
"id": "3164",
"type": "Diseases",
"text": [
"brain diseases"
],
"offsets": [
[
205,
219
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d66.s1.e1"
}
]
},
{
"id": "3165",
"type": "Diseases",
"text": [
"cancers"
],
"offsets": [
[
193,
200
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d66.s1.e2"
}
]
},
{
"id": "3166",
"type": "Diseases",
"text": [
"glioblastoma"
],
"offsets": [
[
312,
324
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d66.s2.e0"
}
]
},
{
"id": "3167",
"type": "Relation_Trigger",
"text": [
"differentially expressed"
],
"offsets": [
[
405,
429
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d66.s3.e0"
}
]
},
{
"id": "3168",
"type": "Relation_Trigger",
"text": [
"differentially expressed"
],
"offsets": [
[
476,
500
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d66.s3.e1"
}
]
},
{
"id": "3169",
"type": "Diseases",
"text": [
"tumor"
],
"offsets": [
[
517,
522
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d66.s3.e2"
}
]
},
{
"id": "3170",
"type": "Non-Specific_miRNAs",
"text": [
"microRNA"
],
"offsets": [
[
570,
578
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d66.s4.e0"
}
]
},
{
"id": "3171",
"type": "Diseases",
"text": [
"glioblastoma"
],
"offsets": [
[
593,
605
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d66.s4.e1"
}
]
},
{
"id": "3172",
"type": "Diseases",
"text": [
"Glioblastoma"
],
"offsets": [
[
621,
633
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d66.s5.e0"
}
]
},
{
"id": "3173",
"type": "Diseases",
"text": [
"brain tumor"
],
"offsets": [
[
661,
672
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d66.s5.e1"
}
]
},
{
"id": "3174",
"type": "Non-Specific_miRNAs",
"text": [
"microRNA"
],
"offsets": [
[
722,
730
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d66.s6.e0"
}
]
},
{
"id": "3175",
"type": "Non-Specific_miRNAs",
"text": [
"microRNA"
],
"offsets": [
[
833,
841
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d66.s6.e1"
}
]
},
{
"id": "3176",
"type": "Diseases",
"text": [
"glioblastoma"
],
"offsets": [
[
845,
857
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d66.s6.e2"
}
]
},
{
"id": "3177",
"type": "Relation_Trigger",
"text": [
"differential expressed"
],
"offsets": [
[
801,
823
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d66.s6.e3"
}
]
},
{
"id": "3178",
"type": "Diseases",
"text": [
"Glioblastoma"
],
"offsets": [
[
745,
757
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d66.s6.e4"
}
]
},
{
"id": "3179",
"type": "Species",
"text": [
"patients"
],
"offsets": [
[
858,
866
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d66.s6.e5"
}
]
},
{
"id": "3180",
"type": "Non-Specific_miRNAs",
"text": [
"microRNAs"
],
"offsets": [
[
926,
935
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d66.s7.e0"
}
]
},
{
"id": "3181",
"type": "Relation_Trigger",
"text": [
"targeted"
],
"offsets": [
[
952,
960
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d66.s7.e1"
}
]
},
{
"id": "3182",
"type": "Relation_Trigger",
"text": [
"associated"
],
"offsets": [
[
967,
977
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d66.s7.e2"
}
]
},
{
"id": "3183",
"type": "Relation_Trigger",
"text": [
"target"
],
"offsets": [
[
898,
904
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d66.s7.e3"
}
]
},
{
"id": "3184",
"type": "Non-Specific_miRNAs",
"text": [
"microRNA"
],
"offsets": [
[
1058,
1066
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d66.s8.e0"
}
]
},
{
"id": "3185",
"type": "Non-Specific_miRNAs",
"text": [
"miRNA"
],
"offsets": [
[
1085,
1090
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d66.s8.e1"
}
]
},
{
"id": "3186",
"type": "Relation_Trigger",
"text": [
"targets"
],
"offsets": [
[
1067,
1074
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d66.s8.e2"
}
]
},
{
"id": "3187",
"type": "Relation_Trigger",
"text": [
"tumor suppressor"
],
"offsets": [
[
1195,
1211
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d66.s8.e3"
}
]
},
{
"id": "3188",
"type": "Relation_Trigger",
"text": [
"target"
],
"offsets": [
[
1177,
1183
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d66.s8.e4"
}
]
},
{
"id": "3189",
"type": "Non-Specific_miRNAs",
"text": [
"microRNA"
],
"offsets": [
[
1273,
1281
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d66.s9.e0"
}
]
},
{
"id": "3190",
"type": "Diseases",
"text": [
"tumor"
],
"offsets": [
[
1300,
1305
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d66.s9.e1"
}
]
},
{
"id": "3191",
"type": "Diseases",
"text": [
"glioblastomas"
],
"offsets": [
[
1430,
1443
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d66.s10.e0"
}
]
}
] | [] | [] | [
{
"id": "3192",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d66.s0.e0",
"arg2_id": "miRNA-corp.d66.s0.e2",
"normalized": []
},
{
"id": "3193",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d66.s4.e0",
"arg2_id": "miRNA-corp.d66.s4.e1",
"normalized": []
},
{
"id": "3194",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d66.s6.e0",
"arg2_id": "miRNA-corp.d66.s6.e2",
"normalized": []
},
{
"id": "3195",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d66.s6.e0",
"arg2_id": "miRNA-corp.d66.s6.e4",
"normalized": []
},
{
"id": "3196",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d66.s6.e1",
"arg2_id": "miRNA-corp.d66.s6.e2",
"normalized": []
},
{
"id": "3197",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d66.s6.e1",
"arg2_id": "miRNA-corp.d66.s6.e4",
"normalized": []
},
{
"id": "3198",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d66.s9.e0",
"arg2_id": "miRNA-corp.d66.s9.e1",
"normalized": []
}
] |
3266 | miRNA-corp.d67 | [
{
"id": "3200",
"type": "title",
"text": [
"CONCLUSION: Our results indicate a time-dependent expression pattern of miR-223 and miR-124a in a mouse model of SCI. "
],
"offsets": [
[
0,
118
]
]
},
{
"id": "3201",
"type": "abstract",
"text": [
"In this study, the time course of miRNA-223 expression may be related to inflammatory responses after SCI, and the time course of decreased miR-124a expression may reflect cell death. "
],
"offsets": [
[
119,
305
]
]
},
{
"id": "3202",
"type": "abstract",
"text": [
"However, miR-124a, which was present in the normal spinal cord, was not observed at the injured site. "
],
"offsets": [
[
306,
408
]
]
},
{
"id": "3203",
"type": "abstract",
"text": [
"RESULTS: Quantitative PCR revealed two peaks of miR-223 expression at 6 and 12 h and 3 days after SCI. MiR-124a expression decreased significantly from 1 day to 7 days after SCI. "
],
"offsets": [
[
409,
588
]
]
},
{
"id": "3204",
"type": "abstract",
"text": [
"In situ hybridization demonstrated the presence of miR-223 around the injured site. "
],
"offsets": [
[
589,
673
]
]
},
{
"id": "3205",
"type": "abstract",
"text": [
"METHODS: We examined the expression of miRNA (miR)-223 and miR-124a in a mouse model at 6 h, 12 h, 1 day, 3 days and 7 days after SCI using quantitative PCR. "
],
"offsets": [
[
674,
832
]
]
},
{
"id": "3206",
"type": "abstract",
"text": [
"The miRNA expression was confirmed by in situ hybridization. "
],
"offsets": [
[
833,
894
]
]
},
{
"id": "3207",
"type": "abstract",
"text": [
"MiRNAs are short noncoding RNAs that suppress the translation of target genes by binding to their mRNAs, and play a central role in gene regulation in health and disease. "
],
"offsets": [
[
895,
1066
]
]
},
{
"id": "3208",
"type": "abstract",
"text": [
"The purpose of this study was to examine miRNA expression after SCI. SETTING: Department of Orthopaedic Surgery, Graduate School of Biomedical Sciences, Hiroshima University. "
],
"offsets": [
[
1067,
1242
]
]
},
{
"id": "3209",
"type": "abstract",
"text": [
"STUDY DESIGN: We investigated microRNA (miRNA) expression after spinal cord injury (SCI) in mice. "
],
"offsets": [
[
1243,
1341
]
]
},
{
"id": "3210",
"type": "abstract",
"text": [
"OBJECTIVES: The recent discovery of miRNAs suggests a novel regulatory control over gene expression during plant and animal development. "
],
"offsets": [
[
1342,
1479
]
]
},
{
"id": "3211",
"type": "abstract",
"text": [
"Responses of microRNAs 124a and 223 following spinal cord injury in mice. "
],
"offsets": [
[
1480,
1555
]
]
}
] | [
{
"id": "3212",
"type": "Specific_miRNAs",
"text": [
"miR-223"
],
"offsets": [
[
72,
79
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d67.s0.e0"
}
]
},
{
"id": "3213",
"type": "Specific_miRNAs",
"text": [
"miR-124a"
],
"offsets": [
[
84,
92
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d67.s0.e1"
}
]
},
{
"id": "3214",
"type": "Diseases",
"text": [
"SCI"
],
"offsets": [
[
113,
116
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d67.s0.e2"
}
]
},
{
"id": "3215",
"type": "Species",
"text": [
"mouse"
],
"offsets": [
[
98,
103
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d67.s0.e3"
}
]
},
{
"id": "3216",
"type": "Specific_miRNAs",
"text": [
"miRNA-223"
],
"offsets": [
[
153,
162
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d67.s1.e0"
}
]
},
{
"id": "3217",
"type": "Specific_miRNAs",
"text": [
"miR-124a"
],
"offsets": [
[
259,
267
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d67.s1.e1"
}
]
},
{
"id": "3218",
"type": "Diseases",
"text": [
"SCI"
],
"offsets": [
[
221,
224
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d67.s1.e2"
}
]
},
{
"id": "3219",
"type": "Relation_Trigger",
"text": [
"decreased miR-124a expression"
],
"offsets": [
[
249,
278
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d67.s1.e3"
}
]
},
{
"id": "3220",
"type": "Specific_miRNAs",
"text": [
"miR-124a"
],
"offsets": [
[
315,
323
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d67.s2.e0"
}
]
},
{
"id": "3221",
"type": "Specific_miRNAs",
"text": [
"miR-223"
],
"offsets": [
[
457,
464
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d67.s3.e0"
}
]
},
{
"id": "3222",
"type": "Specific_miRNAs",
"text": [
"MiR-124a"
],
"offsets": [
[
512,
520
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d67.s3.e1"
}
]
},
{
"id": "3223",
"type": "Diseases",
"text": [
"SCI"
],
"offsets": [
[
507,
510
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d67.s3.e2"
}
]
},
{
"id": "3224",
"type": "Diseases",
"text": [
"SCI"
],
"offsets": [
[
583,
586
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d67.s3.e3"
}
]
},
{
"id": "3225",
"type": "Relation_Trigger",
"text": [
"expression decreased"
],
"offsets": [
[
521,
541
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d67.s3.e4"
}
]
},
{
"id": "3226",
"type": "Relation_Trigger",
"text": [
"decreased significantly"
],
"offsets": [
[
532,
555
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d67.s3.e5"
}
]
},
{
"id": "3227",
"type": "Specific_miRNAs",
"text": [
"miR-223"
],
"offsets": [
[
640,
647
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d67.s4.e0"
}
]
},
{
"id": "3228",
"type": "Specific_miRNAs",
"text": [
"miRNA (miR)-223"
],
"offsets": [
[
713,
728
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d67.s5.e0"
}
]
},
{
"id": "3229",
"type": "Specific_miRNAs",
"text": [
"miR-124a"
],
"offsets": [
[
733,
741
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d67.s5.e1"
}
]
},
{
"id": "3230",
"type": "Diseases",
"text": [
"SCI"
],
"offsets": [
[
804,
807
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d67.s5.e2"
}
]
},
{
"id": "3231",
"type": "Species",
"text": [
"mouse"
],
"offsets": [
[
747,
752
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d67.s5.e3"
}
]
},
{
"id": "3232",
"type": "Non-Specific_miRNAs",
"text": [
"miRNA"
],
"offsets": [
[
837,
842
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d67.s6.e0"
}
]
},
{
"id": "3233",
"type": "Non-Specific_miRNAs",
"text": [
"MiRNAs"
],
"offsets": [
[
895,
901
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d67.s7.e0"
}
]
},
{
"id": "3234",
"type": "Relation_Trigger",
"text": [
"target"
],
"offsets": [
[
960,
966
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d67.s7.e1"
}
]
},
{
"id": "3235",
"type": "Relation_Trigger",
"text": [
"binding"
],
"offsets": [
[
976,
983
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d67.s7.e2"
}
]
},
{
"id": "3236",
"type": "Relation_Trigger",
"text": [
"suppress"
],
"offsets": [
[
932,
940
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d67.s7.e3"
}
]
},
{
"id": "3237",
"type": "Relation_Trigger",
"text": [
"regulation"
],
"offsets": [
[
1032,
1042
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d67.s7.e4"
}
]
},
{
"id": "3238",
"type": "Diseases",
"text": [
"SCI"
],
"offsets": [
[
1131,
1134
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d67.s8.e0"
}
]
},
{
"id": "3239",
"type": "Non-Specific_miRNAs",
"text": [
"miRNA"
],
"offsets": [
[
1108,
1113
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d67.s8.e1"
}
]
},
{
"id": "3240",
"type": "Diseases",
"text": [
"spinal cord injury"
],
"offsets": [
[
1307,
1325
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d67.s9.e0"
}
]
},
{
"id": "3241",
"type": "Diseases",
"text": [
"SCI"
],
"offsets": [
[
1327,
1330
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d67.s9.e1"
}
]
},
{
"id": "3242",
"type": "Non-Specific_miRNAs",
"text": [
"microRNA"
],
"offsets": [
[
1273,
1281
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d67.s9.e2"
}
]
},
{
"id": "3243",
"type": "Non-Specific_miRNAs",
"text": [
"miRNA"
],
"offsets": [
[
1283,
1288
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d67.s9.e3"
}
]
},
{
"id": "3244",
"type": "Species",
"text": [
"mice"
],
"offsets": [
[
1335,
1339
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d67.s9.e4"
}
]
},
{
"id": "3245",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
[
1378,
1384
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d67.s10.e0"
}
]
},
{
"id": "3246",
"type": "Relation_Trigger",
"text": [
"regulatory"
],
"offsets": [
[
1402,
1412
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d67.s10.e1"
}
]
},
{
"id": "3247",
"type": "Specific_miRNAs",
"text": [
"microRNAs 124a and 223"
],
"offsets": [
[
1493,
1515
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d67.s11.e0"
}
]
},
{
"id": "3248",
"type": "Diseases",
"text": [
"spinal cord injury"
],
"offsets": [
[
1526,
1544
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d67.s11.e1"
}
]
},
{
"id": "3249",
"type": "Species",
"text": [
"mice"
],
"offsets": [
[
1548,
1552
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d67.s11.e2"
}
]
}
] | [] | [] | [
{
"id": "3250",
"type": "Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d67.s0.e0",
"arg2_id": "miRNA-corp.d67.s0.e2",
"normalized": []
},
{
"id": "3251",
"type": "Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d67.s0.e1",
"arg2_id": "miRNA-corp.d67.s0.e2",
"normalized": []
},
{
"id": "3252",
"type": "Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d67.s1.e0",
"arg2_id": "miRNA-corp.d67.s1.e2",
"normalized": []
},
{
"id": "3253",
"type": "Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d67.s1.e1",
"arg2_id": "miRNA-corp.d67.s1.e2",
"normalized": []
},
{
"id": "3254",
"type": "Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d67.s3.e0",
"arg2_id": "miRNA-corp.d67.s3.e2",
"normalized": []
},
{
"id": "3255",
"type": "Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d67.s3.e0",
"arg2_id": "miRNA-corp.d67.s3.e3",
"normalized": []
},
{
"id": "3256",
"type": "Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d67.s3.e1",
"arg2_id": "miRNA-corp.d67.s3.e2",
"normalized": []
},
{
"id": "3257",
"type": "Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d67.s3.e1",
"arg2_id": "miRNA-corp.d67.s3.e3",
"normalized": []
},
{
"id": "3258",
"type": "Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d67.s5.e0",
"arg2_id": "miRNA-corp.d67.s5.e2",
"normalized": []
},
{
"id": "3259",
"type": "Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d67.s5.e1",
"arg2_id": "miRNA-corp.d67.s5.e2",
"normalized": []
},
{
"id": "3260",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d67.s8.e1",
"arg2_id": "miRNA-corp.d67.s8.e0",
"normalized": []
},
{
"id": "3261",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d67.s9.e2",
"arg2_id": "miRNA-corp.d67.s9.e0",
"normalized": []
},
{
"id": "3262",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d67.s9.e2",
"arg2_id": "miRNA-corp.d67.s9.e1",
"normalized": []
},
{
"id": "3263",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d67.s9.e3",
"arg2_id": "miRNA-corp.d67.s9.e0",
"normalized": []
},
{
"id": "3264",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d67.s9.e3",
"arg2_id": "miRNA-corp.d67.s9.e1",
"normalized": []
},
{
"id": "3265",
"type": "Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d67.s11.e0",
"arg2_id": "miRNA-corp.d67.s11.e1",
"normalized": []
}
] |
3357 | miRNA-corp.d68 | [
{
"id": "3267",
"type": "title",
"text": [
"Aberrant microRNA expression in the brains of neurodegenerative diseases: miR-29a decreased in Alzheimer disease brains targets neurone navigator 3. AIMS: MicroRNAs (miRNAs) are small non-coding RNAs that regulate translational repression of target mRNAs. "
],
"offsets": [
[
0,
257
]
]
},
{
"id": "3268",
"type": "abstract",
"text": [
"MiR-29a-mediated down-regulation of NAV3 was verified by the luciferase reporter assay. "
],
"offsets": [
[
258,
346
]
]
},
{
"id": "3269",
"type": "abstract",
"text": [
"However, we found significant down-regulation of miR-29a in Alzheimer disease (AD) brains. "
],
"offsets": [
[
347,
438
]
]
},
{
"id": "3270",
"type": "abstract",
"text": [
"The database search on TargetScan, PicTar and miRBase Target identified neurone navigator 3 (NAV3), a regulator of axon guidance, as a principal target of miR-29a, and actually NAV3 mRNA levels were elevated in AD brains. "
],
"offsets": [
[
439,
661
]
]
},
{
"id": "3271",
"type": "abstract",
"text": [
"RESULTS: By microarray analysis, we identified up-regulation of miR-29a, miR-29b and miR-338-3p in amyotrophic lateral sclerosis brains, but due to a great interindividual variation, we could not validate these results by quantitative RT-PCR. "
],
"offsets": [
[
662,
905
]
]
},
{
"id": "3272",
"type": "abstract",
"text": [
"To identify miRNAs closely associated with neurodegeneration, we performed miRNA expression profiling of brain tissues of various neurodegenerative diseases. "
],
"offsets": [
[
906,
1064
]
]
},
{
"id": "3273",
"type": "abstract",
"text": [
"METHODS: We initially studied the frontal cortex derived from three amyotrophic lateral sclerosis patients by using a microarray of 723 human miRNAs. "
],
"offsets": [
[
1065,
1215
]
]
},
{
"id": "3274",
"type": "abstract",
"text": [
"Accumulating evidence indicates that various miRNAs, expressed in a spatially and temporally controlled that manner in the brain plays a key role in neuronal development. "
],
"offsets": [
[
1216,
1387
]
]
},
{
"id": "3275",
"type": "abstract",
"text": [
"However, at present, the pathological implication of aberrant miRNA expression in neurodegenerative events remains largely unknown. "
],
"offsets": [
[
1388,
1520
]
]
},
{
"id": "3276",
"type": "abstract",
"text": [
"By immunohistochemistry, NAV3 expression was most evidently enhanced in degenerating pyramidal neurones in the cerebral cortex of AD. CONCLUSIONS: These observations suggest the hypothesis that underexpression of miR-29a affects neurodegenerative processes by enhancing neuronal NAV3 expression in AD brains. "
],
"offsets": [
[
1521,
1832
]
]
}
] | [
{
"id": "3277",
"type": "Non-Specific_miRNAs",
"text": [
"MicroRNAs"
],
"offsets": [
[
156,
165
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d68.s0.e0"
}
]
},
{
"id": "3278",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
[
167,
173
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d68.s0.e1"
}
]
},
{
"id": "3279",
"type": "Non-Specific_miRNAs",
"text": [
"microRNA"
],
"offsets": [
[
9,
17
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d68.s0.e2"
}
]
},
{
"id": "3280",
"type": "Relation_Trigger",
"text": [
"Aberrant microRNA expression"
],
"offsets": [
[
0,
28
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d68.s0.e3"
}
]
},
{
"id": "3281",
"type": "Relation_Trigger",
"text": [
"targets"
],
"offsets": [
[
120,
127
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d68.s0.e4"
}
]
},
{
"id": "3282",
"type": "Specific_miRNAs",
"text": [
"miR-29a"
],
"offsets": [
[
74,
81
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d68.s0.e5"
}
]
},
{
"id": "3283",
"type": "Diseases",
"text": [
"Alzheimer disease"
],
"offsets": [
[
95,
112
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d68.s0.e6"
}
]
},
{
"id": "3284",
"type": "Genes/Proteins",
"text": [
"neurone navigator 3"
],
"offsets": [
[
128,
147
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d68.s0.e7"
}
]
},
{
"id": "3285",
"type": "Relation_Trigger",
"text": [
"target"
],
"offsets": [
[
243,
249
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d68.s0.e8"
}
]
},
{
"id": "3286",
"type": "Relation_Trigger",
"text": [
"translational repression"
],
"offsets": [
[
215,
239
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d68.s0.e9"
}
]
},
{
"id": "3287",
"type": "Relation_Trigger",
"text": [
"regulate"
],
"offsets": [
[
206,
214
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d68.s0.e10"
}
]
},
{
"id": "3288",
"type": "Diseases",
"text": [
"neurodegenerative diseases"
],
"offsets": [
[
46,
72
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d68.s0.e11"
}
]
},
{
"id": "3289",
"type": "Specific_miRNAs",
"text": [
"MiR-29a"
],
"offsets": [
[
258,
265
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d68.s1.e0"
}
]
},
{
"id": "3290",
"type": "Relation_Trigger",
"text": [
"down-regulation"
],
"offsets": [
[
275,
290
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d68.s1.e1"
}
]
},
{
"id": "3291",
"type": "Genes/Proteins",
"text": [
"NAV3"
],
"offsets": [
[
294,
298
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d68.s1.e2"
}
]
},
{
"id": "3292",
"type": "Relation_Trigger",
"text": [
"down-regulation"
],
"offsets": [
[
377,
392
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d68.s2.e0"
}
]
},
{
"id": "3293",
"type": "Specific_miRNAs",
"text": [
"miR-29a"
],
"offsets": [
[
396,
403
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d68.s2.e1"
}
]
},
{
"id": "3294",
"type": "Diseases",
"text": [
"Alzheimer disease"
],
"offsets": [
[
407,
424
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d68.s2.e2"
}
]
},
{
"id": "3295",
"type": "Diseases",
"text": [
"AD"
],
"offsets": [
[
426,
428
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d68.s2.e3"
}
]
},
{
"id": "3296",
"type": "Relation_Trigger",
"text": [
"principal target"
],
"offsets": [
[
574,
590
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d68.s3.e0"
}
]
},
{
"id": "3297",
"type": "Genes/Proteins",
"text": [
"neurone navigator 3"
],
"offsets": [
[
511,
530
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
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"id": "3303",
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{
"id": "3304",
"type": "Relation_Trigger",
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"levels were elevated"
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626,
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"id": "3305",
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"amyotrophic lateral sclerosis"
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"id": "3306",
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"up-regulation"
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"id": "3307",
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"miR-29a"
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"id": "3308",
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"miR-29b"
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"id": "3309",
"type": "Specific_miRNAs",
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"miR-338-3p"
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"id": "3310",
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"miRNAs"
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{
"id": "3311",
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"miRNA"
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{
"id": "3312",
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"associated"
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"id": "3313",
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{
"id": "3314",
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"miRNAs"
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1207,
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]
},
{
"id": "3315",
"type": "Species",
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"patients"
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},
{
"id": "3316",
"type": "Species",
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},
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"id": "3317",
"type": "Diseases",
"text": [
"amyotrophic lateral sclerosis"
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1133,
1162
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},
{
"id": "3318",
"type": "Non-Specific_miRNAs",
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"miRNAs"
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1267
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"id": "3319",
"type": "Non-Specific_miRNAs",
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}
]
},
{
"id": "3320",
"type": "Relation_Trigger",
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1441,
1466
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]
},
{
"id": "3321",
"type": "Relation_Trigger",
"text": [
"underexpression"
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1715,
1730
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}
]
},
{
"id": "3322",
"type": "Relation_Trigger",
"text": [
"enhancing neuronal NAV3 expression"
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1781,
1815
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]
},
{
"id": "3323",
"type": "Genes/Proteins",
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1550
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}
]
},
{
"id": "3324",
"type": "Diseases",
"text": [
"AD"
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1819,
1821
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]
},
{
"id": "3325",
"type": "Diseases",
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"AD"
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1651,
1653
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"db_id": "miRNA-corp.d68.s10.e4"
}
]
},
{
"id": "3326",
"type": "Specific_miRNAs",
"text": [
"miR-29a"
],
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1734,
1741
]
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"db_id": "miRNA-corp.d68.s10.e5"
}
]
},
{
"id": "3327",
"type": "Genes/Proteins",
"text": [
"NAV3"
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1800,
1804
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d68.s10.e6"
}
]
}
] | [] | [] | [
{
"id": "3328",
"type": "Non-Specific_miRNAs-Diseases",
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"arg2_id": "miRNA-corp.d68.s0.e6",
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},
{
"id": "3329",
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{
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{
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{
"id": "3332",
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{
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},
{
"id": "3334",
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},
{
"id": "3335",
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},
{
"id": "3336",
"type": "Specific_miRNAs-Diseases",
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"arg2_id": "miRNA-corp.d68.s0.e11",
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},
{
"id": "3337",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d68.s0.e2",
"arg2_id": "miRNA-corp.d68.s0.e6",
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},
{
"id": "3338",
"type": "Non-Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d68.s0.e2",
"arg2_id": "miRNA-corp.d68.s0.e7",
"normalized": []
},
{
"id": "3339",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d68.s0.e2",
"arg2_id": "miRNA-corp.d68.s0.e11",
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},
{
"id": "3340",
"type": "Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d68.s1.e0",
"arg2_id": "miRNA-corp.d68.s1.e2",
"normalized": []
},
{
"id": "3341",
"type": "Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d68.s2.e1",
"arg2_id": "miRNA-corp.d68.s2.e2",
"normalized": []
},
{
"id": "3342",
"type": "Specific_miRNAs-Diseases",
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"arg2_id": "miRNA-corp.d68.s2.e3",
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},
{
"id": "3343",
"type": "Specific_miRNAs-Genes/Proteins",
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},
{
"id": "3344",
"type": "Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d68.s3.e4",
"arg2_id": "miRNA-corp.d68.s3.e2",
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},
{
"id": "3345",
"type": "Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d68.s3.e4",
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},
{
"id": "3346",
"type": "Specific_miRNAs-Diseases",
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},
{
"id": "3347",
"type": "Specific_miRNAs-Diseases",
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"arg2_id": "miRNA-corp.d68.s5.e0",
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},
{
"id": "3348",
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},
{
"id": "3349",
"type": "Specific_miRNAs-Diseases",
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},
{
"id": "3350",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d68.s6.e0",
"arg2_id": "miRNA-corp.d68.s6.e3",
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},
{
"id": "3351",
"type": "Non-Specific_miRNAs-Diseases",
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},
{
"id": "3352",
"type": "Non-Specific_miRNAs-Diseases",
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},
{
"id": "3353",
"type": "Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d68.s10.e5",
"arg2_id": "miRNA-corp.d68.s10.e2",
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},
{
"id": "3354",
"type": "Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d68.s10.e5",
"arg2_id": "miRNA-corp.d68.s10.e3",
"normalized": []
},
{
"id": "3355",
"type": "Specific_miRNAs-Diseases",
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},
{
"id": "3356",
"type": "Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d68.s10.e5",
"arg2_id": "miRNA-corp.d68.s10.e6",
"normalized": []
}
] |
3419 | miRNA-corp.d69 | [
{
"id": "3358",
"type": "title",
"text": [
"Many miRNA targets have been computationally predicted but only a limited number of these were experimentally validated. "
],
"offsets": [
[
0,
121
]
]
},
{
"id": "3359",
"type": "abstract",
"text": [
"However, interactions between miRNAs and their targets are complex and very often there are numerous putative miRNA recognition sites in mRNAs. "
],
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[
122,
266
]
]
},
{
"id": "3360",
"type": "abstract",
"text": [
"Therefore, it is of particular interest to reliably predict potential miRNA targets which might be involved in these diseases. "
],
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[
267,
394
]
]
},
{
"id": "3361",
"type": "abstract",
"text": [
"Both the deregulation of genes controlled by miRNAs and the altered miRNA expression have been linked to many disorders, including cancer, cardiovascular, metabolic and neurodegenerative diseases. "
],
"offsets": [
[
395,
592
]
]
},
{
"id": "3362",
"type": "abstract",
"text": [
"In this review, currently available and frequently used computational tools for miRNA target prediction, i.e., PicTar, TargetScan, DIANA-microT, miRanda, rna22 and PITA are outlined and various practical aspects of miRNA target analysis are extensively discussed. "
],
"offsets": [
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593,
857
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]
},
{
"id": "3363",
"type": "abstract",
"text": [
"Hence, finding a functional miRNA target is still a challenging task. "
],
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858,
928
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]
},
{
"id": "3364",
"type": "abstract",
"text": [
"Although a variety of miRNA target prediction algorithms are available, results of their application are often inconsistent. "
],
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929,
1054
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]
},
{
"id": "3365",
"type": "abstract",
"text": [
"microRNAs (miRNAs) are endogenous non-coding RNAs that control gene expression at the posttranscriptional level. "
],
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1055,
1168
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]
},
{
"id": "3366",
"type": "abstract",
"text": [
"These small regulatory molecules play a key role in the majority of biological processes and their expression is also tightly regulated. "
],
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1169,
1306
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]
},
{
"id": "3367",
"type": "abstract",
"text": [
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],
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[
1307,
1357
]
]
},
{
"id": "3368",
"type": "abstract",
"text": [
"Moreover, the performance of three algorithms (PicTar, TargetScan and DIANA-microT) is both demonstrated and evaluated by performing an in-depth analysis of miRNA interactions with mRNAs derived from genes triggering hereditary neurological disorders known as trinucleotide repeat expansion diseases (TREDs), such as Huntington's disease (HD), a number of spinocerebellar ataxias (SCAs), and myotonic dystrophy type 1 (DM1). "
],
"offsets": [
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1358,
1785
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]
}
] | [
{
"id": "3369",
"type": "Non-Specific_miRNAs",
"text": [
"miRNA"
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[
5,
10
]
],
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]
},
{
"id": "3370",
"type": "Relation_Trigger",
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"targets"
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11,
18
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],
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]
},
{
"id": "3371",
"type": "Non-Specific_miRNAs",
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"miRNAs"
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152,
158
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],
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"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d69.s1.e0"
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]
},
{
"id": "3372",
"type": "Non-Specific_miRNAs",
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"miRNA"
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232,
237
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]
},
{
"id": "3373",
"type": "Relation_Trigger",
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169,
176
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]
},
{
"id": "3374",
"type": "Non-Specific_miRNAs",
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337,
342
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]
},
{
"id": "3375",
"type": "Relation_Trigger",
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"potential miRNA targets"
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327,
350
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]
},
{
"id": "3376",
"type": "Non-Specific_miRNAs",
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"miRNAs"
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440,
446
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],
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]
},
{
"id": "3377",
"type": "Non-Specific_miRNAs",
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"miRNA"
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463,
468
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],
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]
},
{
"id": "3378",
"type": "Relation_Trigger",
"text": [
"altered miRNA expression"
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[
455,
479
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d69.s3.e2"
}
]
},
{
"id": "3379",
"type": "Diseases",
"text": [
"cancer"
],
"offsets": [
[
526,
532
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d69.s3.e3"
}
]
},
{
"id": "3380",
"type": "Diseases",
"text": [
"neurodegenerative diseases"
],
"offsets": [
[
564,
590
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d69.s3.e4"
}
]
},
{
"id": "3381",
"type": "Relation_Trigger",
"text": [
"deregulation"
],
"offsets": [
[
404,
416
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d69.s3.e5"
}
]
},
{
"id": "3382",
"type": "Non-Specific_miRNAs",
"text": [
"miRNA"
],
"offsets": [
[
673,
678
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d69.s4.e0"
}
]
},
{
"id": "3383",
"type": "Non-Specific_miRNAs",
"text": [
"miRNA"
],
"offsets": [
[
808,
813
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d69.s4.e1"
}
]
},
{
"id": "3384",
"type": "Relation_Trigger",
"text": [
"target"
],
"offsets": [
[
679,
685
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d69.s4.e2"
}
]
},
{
"id": "3385",
"type": "Relation_Trigger",
"text": [
"target"
],
"offsets": [
[
814,
820
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d69.s4.e3"
}
]
},
{
"id": "3386",
"type": "Non-Specific_miRNAs",
"text": [
"miRNA"
],
"offsets": [
[
886,
891
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d69.s5.e0"
}
]
},
{
"id": "3387",
"type": "Relation_Trigger",
"text": [
"functional miRNA target"
],
"offsets": [
[
875,
898
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d69.s5.e1"
}
]
},
{
"id": "3388",
"type": "Non-Specific_miRNAs",
"text": [
"miRNA"
],
"offsets": [
[
951,
956
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d69.s6.e0"
}
]
},
{
"id": "3389",
"type": "Relation_Trigger",
"text": [
"target"
],
"offsets": [
[
957,
963
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d69.s6.e1"
}
]
},
{
"id": "3390",
"type": "Non-Specific_miRNAs",
"text": [
"microRNAs"
],
"offsets": [
[
1055,
1064
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d69.s7.e0"
}
]
},
{
"id": "3391",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
[
1066,
1072
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d69.s7.e1"
}
]
},
{
"id": "3392",
"type": "Relation_Trigger",
"text": [
"expression is also tightly regulated"
],
"offsets": [
[
1268,
1304
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d69.s8.e0"
}
]
},
{
"id": "3393",
"type": "Relation_Trigger",
"text": [
"regulatory"
],
"offsets": [
[
1181,
1191
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d69.s8.e1"
}
]
},
{
"id": "3394",
"type": "Non-Specific_miRNAs",
"text": [
"microRNA"
],
"offsets": [
[
1328,
1336
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d69.s9.e0"
}
]
},
{
"id": "3395",
"type": "Relation_Trigger",
"text": [
"Target"
],
"offsets": [
[
1337,
1343
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d69.s9.e1"
}
]
},
{
"id": "3396",
"type": "Non-Specific_miRNAs",
"text": [
"miRNA"
],
"offsets": [
[
1515,
1520
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d69.s10.e0"
}
]
},
{
"id": "3397",
"type": "Diseases",
"text": [
"trinucleotide repeat expansion diseases"
],
"offsets": [
[
1618,
1657
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d69.s10.e1"
}
]
},
{
"id": "3398",
"type": "Diseases",
"text": [
"TREDs"
],
"offsets": [
[
1659,
1664
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d69.s10.e2"
}
]
},
{
"id": "3399",
"type": "Diseases",
"text": [
"Huntington's disease"
],
"offsets": [
[
1675,
1695
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d69.s10.e3"
}
]
},
{
"id": "3400",
"type": "Diseases",
"text": [
"HD"
],
"offsets": [
[
1697,
1699
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d69.s10.e4"
}
]
},
{
"id": "3401",
"type": "Diseases",
"text": [
"spinocerebellar ataxias"
],
"offsets": [
[
1714,
1737
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d69.s10.e5"
}
]
},
{
"id": "3402",
"type": "Diseases",
"text": [
"SCAs"
],
"offsets": [
[
1739,
1743
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d69.s10.e6"
}
]
},
{
"id": "3403",
"type": "Diseases",
"text": [
"myotonic dystrophy type 1"
],
"offsets": [
[
1750,
1775
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d69.s10.e7"
}
]
},
{
"id": "3404",
"type": "Diseases",
"text": [
"DM1"
],
"offsets": [
[
1777,
1780
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d69.s10.e8"
}
]
},
{
"id": "3405",
"type": "Diseases",
"text": [
"neurological disorders"
],
"offsets": [
[
1586,
1608
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d69.s10.e9"
}
]
}
] | [] | [] | [
{
"id": "3406",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d69.s3.e0",
"arg2_id": "miRNA-corp.d69.s3.e3",
"normalized": []
},
{
"id": "3407",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d69.s3.e0",
"arg2_id": "miRNA-corp.d69.s3.e4",
"normalized": []
},
{
"id": "3408",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d69.s3.e1",
"arg2_id": "miRNA-corp.d69.s3.e3",
"normalized": []
},
{
"id": "3409",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d69.s3.e1",
"arg2_id": "miRNA-corp.d69.s3.e4",
"normalized": []
},
{
"id": "3410",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d69.s10.e0",
"arg2_id": "miRNA-corp.d69.s10.e1",
"normalized": []
},
{
"id": "3411",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d69.s10.e0",
"arg2_id": "miRNA-corp.d69.s10.e2",
"normalized": []
},
{
"id": "3412",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d69.s10.e0",
"arg2_id": "miRNA-corp.d69.s10.e3",
"normalized": []
},
{
"id": "3413",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d69.s10.e0",
"arg2_id": "miRNA-corp.d69.s10.e4",
"normalized": []
},
{
"id": "3414",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d69.s10.e0",
"arg2_id": "miRNA-corp.d69.s10.e5",
"normalized": []
},
{
"id": "3415",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d69.s10.e0",
"arg2_id": "miRNA-corp.d69.s10.e6",
"normalized": []
},
{
"id": "3416",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d69.s10.e0",
"arg2_id": "miRNA-corp.d69.s10.e7",
"normalized": []
},
{
"id": "3417",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d69.s10.e0",
"arg2_id": "miRNA-corp.d69.s10.e8",
"normalized": []
},
{
"id": "3418",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d69.s10.e0",
"arg2_id": "miRNA-corp.d69.s10.e9",
"normalized": []
}
] |
3491 | miRNA-corp.d70 | [
{
"id": "3420",
"type": "title",
"text": [
"CONCLUSIONS: Our results indicate that altered miRNAs expression is involved in GH-secreting pituitary adenomas transformation, which will shed light on the mechanisms for the treatment of acromegaly by SSA. "
],
"offsets": [
[
0,
208
]
]
},
{
"id": "3421",
"type": "abstract",
"text": [
"Identification and characterization of the targets of altered miRNAs genes may elucidate molecular mechanisms involved in the pathogenesis of pituitary adenoma. "
],
"offsets": [
[
209,
372
]
]
},
{
"id": "3422",
"type": "abstract",
"text": [
"Several identified miRNAs may be involved in cell proliferation, apoptosis, cancer development and progression. "
],
"offsets": [
[
373,
485
]
]
},
{
"id": "3423",
"type": "abstract",
"text": [
"Seven miRNAs were differentially expressed between SSA responders or GH nonresponders. "
],
"offsets": [
[
486,
573
]
]
},
{
"id": "3424",
"type": "abstract",
"text": [
"RESULTS: Fifty-two miRNAs were differentially expressed between GH-secreting pituitary adenomas and normal pituitaries. "
],
"offsets": [
[
574,
694
]
]
},
{
"id": "3425",
"type": "abstract",
"text": [
"We analyzed the miRNAs in 21 GH-secreting pituitary adenomas and 6 normal pituitaries by miRCURY™ LNA array and some differentially expressed miRNAs were validated by quantitative real-time PCR. "
],
"offsets": [
[
695,
890
]
]
},
{
"id": "3426",
"type": "abstract",
"text": [
"Thirteen miRNAs were differentially expressed between tumor samples from lanreotide-treated patients and those from lanreotide-untreated patients. "
],
"offsets": [
[
891,
1038
]
]
},
{
"id": "3427",
"type": "abstract",
"text": [
"Differential expression of 9 miRNAs was observed between micro- and macro-adenomas. "
],
"offsets": [
[
1039,
1123
]
]
},
{
"id": "3428",
"type": "abstract",
"text": [
"Differential expression of microRNAs in GH-secreting pituitary adenomas. "
],
"offsets": [
[
1124,
1198
]
]
},
{
"id": "3429",
"type": "abstract",
"text": [
"BACKGROUND: The purpose of this study was to (1) identify specific miRNAs in growth hormones (GH)-secreting pituitary adenomas; (2) determine the relationship between the expression of these miRNAs and tumor size, somatostatin analogs treatment, and responsiveness to somatostatin analogs (SSA). "
],
"offsets": [
[
1199,
1495
]
]
},
{
"id": "3430",
"type": "abstract",
"text": [
"METHODS: Fifteen GH-secreting adenomas patients were treated with lanreotide for 4 months before surgery. "
],
"offsets": [
[
1496,
1602
]
]
},
{
"id": "3431",
"type": "abstract",
"text": [
"Patients with 50% reduction of GH secretion by lanreotide were considered as SSA responders, while patients with less than 50% of GH reduction were considered as SSA nonresponders. "
],
"offsets": [
[
1603,
1784
]
]
}
] | [
{
"id": "3432",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
[
47,
53
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d70.s0.e0"
}
]
},
{
"id": "3433",
"type": "Relation_Trigger",
"text": [
"altered miRNAs expression"
],
"offsets": [
[
39,
64
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d70.s0.e1"
}
]
},
{
"id": "3434",
"type": "Diseases",
"text": [
"acromegaly"
],
"offsets": [
[
189,
199
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d70.s0.e2"
}
]
},
{
"id": "3435",
"type": "Diseases",
"text": [
"pituitary adenomas"
],
"offsets": [
[
93,
111
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d70.s0.e3"
}
]
},
{
"id": "3436",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
[
271,
277
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d70.s1.e0"
}
]
},
{
"id": "3437",
"type": "Diseases",
"text": [
"pituitary adenoma"
],
"offsets": [
[
351,
368
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d70.s1.e1"
}
]
},
{
"id": "3438",
"type": "Relation_Trigger",
"text": [
"targets"
],
"offsets": [
[
252,
259
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d70.s1.e2"
}
]
},
{
"id": "3439",
"type": "Diseases",
"text": [
"adenoma"
],
"offsets": [
[
361,
368
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d70.s1.e3"
}
]
},
{
"id": "3440",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
[
392,
398
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d70.s2.e0"
}
]
},
{
"id": "3441",
"type": "Diseases",
"text": [
"cancer"
],
"offsets": [
[
449,
455
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d70.s2.e1"
}
]
},
{
"id": "3442",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
[
492,
498
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d70.s3.e0"
}
]
},
{
"id": "3443",
"type": "Relation_Trigger",
"text": [
"differentially expressed"
],
"offsets": [
[
504,
528
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d70.s3.e1"
}
]
},
{
"id": "3444",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
[
593,
599
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d70.s4.e0"
}
]
},
{
"id": "3445",
"type": "Relation_Trigger",
"text": [
"differentially expressed"
],
"offsets": [
[
605,
629
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d70.s4.e1"
}
]
},
{
"id": "3446",
"type": "Diseases",
"text": [
"pituitary adenomas"
],
"offsets": [
[
651,
669
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d70.s4.e2"
}
]
},
{
"id": "3447",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
[
711,
717
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d70.s5.e0"
}
]
},
{
"id": "3448",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
[
837,
843
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d70.s5.e1"
}
]
},
{
"id": "3449",
"type": "Diseases",
"text": [
"pituitary adenomas"
],
"offsets": [
[
737,
755
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d70.s5.e2"
}
]
},
{
"id": "3450",
"type": "Relation_Trigger",
"text": [
"differentially expressed"
],
"offsets": [
[
812,
836
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d70.s5.e3"
}
]
},
{
"id": "3451",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
[
900,
906
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d70.s6.e0"
}
]
},
{
"id": "3452",
"type": "Relation_Trigger",
"text": [
"differentially expressed"
],
"offsets": [
[
912,
936
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d70.s6.e1"
}
]
},
{
"id": "3453",
"type": "Diseases",
"text": [
"tumor"
],
"offsets": [
[
945,
950
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d70.s6.e2"
}
]
},
{
"id": "3454",
"type": "Species",
"text": [
"patients"
],
"offsets": [
[
1028,
1036
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d70.s6.e3"
}
]
},
{
"id": "3455",
"type": "Species",
"text": [
"patients"
],
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983,
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{
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]
},
{
"id": "3456",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
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},
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"id": "3457",
"type": "Diseases",
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},
{
"id": "3458",
"type": "Relation_Trigger",
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1039,
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{
"id": "3459",
"type": "Non-Specific_miRNAs",
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"microRNAs"
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1151,
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}
]
},
{
"id": "3460",
"type": "Diseases",
"text": [
"pituitary adenomas"
],
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[
1177,
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]
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{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d70.s8.e1"
}
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},
{
"id": "3461",
"type": "Relation_Trigger",
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"Differential expression"
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[
1124,
1147
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{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d70.s8.e2"
}
]
},
{
"id": "3462",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
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1266,
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{
"id": "3463",
"type": "Non-Specific_miRNAs",
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"miRNAs"
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1390,
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}
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},
{
"id": "3464",
"type": "Diseases",
"text": [
"pituitary adenomas"
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1307,
1325
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}
]
},
{
"id": "3465",
"type": "Genes/Proteins",
"text": [
"somatostatin"
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[
1413,
1425
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"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d70.s9.e3"
}
]
},
{
"id": "3466",
"type": "Genes/Proteins",
"text": [
"somatostatin"
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1467,
1479
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"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d70.s9.e4"
}
]
},
{
"id": "3467",
"type": "Diseases",
"text": [
"tumor"
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1401,
1406
]
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"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d70.s9.e5"
}
]
},
{
"id": "3468",
"type": "Diseases",
"text": [
"adenomas"
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[
1526,
1534
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{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d70.s10.e0"
}
]
},
{
"id": "3469",
"type": "Species",
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"patients"
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1535,
1543
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{
"db_name": "miRNA-corpus",
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}
]
},
{
"id": "3470",
"type": "Species",
"text": [
"Patients"
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1603,
1611
]
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{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d70.s11.e0"
}
]
},
{
"id": "3471",
"type": "Species",
"text": [
"patients"
],
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[
1702,
1710
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d70.s11.e1"
}
]
}
] | [] | [] | [
{
"id": "3472",
"type": "Non-Specific_miRNAs-Diseases",
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"arg2_id": "miRNA-corp.d70.s0.e2",
"normalized": []
},
{
"id": "3473",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d70.s0.e0",
"arg2_id": "miRNA-corp.d70.s0.e3",
"normalized": []
},
{
"id": "3474",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d70.s1.e0",
"arg2_id": "miRNA-corp.d70.s1.e1",
"normalized": []
},
{
"id": "3475",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d70.s1.e0",
"arg2_id": "miRNA-corp.d70.s1.e3",
"normalized": []
},
{
"id": "3476",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d70.s2.e0",
"arg2_id": "miRNA-corp.d70.s2.e1",
"normalized": []
},
{
"id": "3477",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d70.s4.e0",
"arg2_id": "miRNA-corp.d70.s4.e2",
"normalized": []
},
{
"id": "3478",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d70.s5.e0",
"arg2_id": "miRNA-corp.d70.s5.e2",
"normalized": []
},
{
"id": "3479",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d70.s5.e1",
"arg2_id": "miRNA-corp.d70.s5.e2",
"normalized": []
},
{
"id": "3480",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d70.s6.e0",
"arg2_id": "miRNA-corp.d70.s6.e2",
"normalized": []
},
{
"id": "3481",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d70.s7.e0",
"arg2_id": "miRNA-corp.d70.s7.e1",
"normalized": []
},
{
"id": "3482",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d70.s8.e0",
"arg2_id": "miRNA-corp.d70.s8.e1",
"normalized": []
},
{
"id": "3483",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d70.s9.e0",
"arg2_id": "miRNA-corp.d70.s9.e2",
"normalized": []
},
{
"id": "3484",
"type": "Non-Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d70.s9.e0",
"arg2_id": "miRNA-corp.d70.s9.e3",
"normalized": []
},
{
"id": "3485",
"type": "Non-Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d70.s9.e0",
"arg2_id": "miRNA-corp.d70.s9.e4",
"normalized": []
},
{
"id": "3486",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d70.s9.e0",
"arg2_id": "miRNA-corp.d70.s9.e5",
"normalized": []
},
{
"id": "3487",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d70.s9.e1",
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"normalized": []
},
{
"id": "3488",
"type": "Non-Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d70.s9.e1",
"arg2_id": "miRNA-corp.d70.s9.e3",
"normalized": []
},
{
"id": "3489",
"type": "Non-Specific_miRNAs-Genes/Proteins",
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"normalized": []
},
{
"id": "3490",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d70.s9.e1",
"arg2_id": "miRNA-corp.d70.s9.e5",
"normalized": []
}
] |
3559 | miRNA-corp.d71 | [
{
"id": "3492",
"type": "title",
"text": [
"We recently showed in HeLa cells that two components of the SMN complex, Gemin3 and Gemin4, together with the argonaute protein eIF2C2, also associate with microRNAs (miRNAs) as part of a novel class of RNPs termed miRNPs. "
],
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0,
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]
},
{
"id": "3493",
"type": "abstract",
"text": [
"SMN is part of a large complex that functions in the assembly/restructuring of ribonucleoprotein (RNP) complexes. "
],
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224,
338
]
]
},
{
"id": "3494",
"type": "abstract",
"text": [
"Spinal muscular atrophy (SMA) is a common neurodegenerative disease that is caused by deletions or loss-of-function mutations in the Survival of Motor Neuron (SMN) protein. "
],
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339,
512
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]
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{
"id": "3495",
"type": "abstract",
"text": [
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],
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513,
579
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]
},
{
"id": "3496",
"type": "abstract",
"text": [
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],
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[
580,
730
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]
},
{
"id": "3497",
"type": "abstract",
"text": [
"Interestingly the gene locus of one miRNA, miR-175, is a candidate region for two neurologic diseases: early-onset parkinsonism (Waisman syndrome) and X-linked mental retardation (MRX3). "
],
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731,
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]
},
{
"id": "3498",
"type": "abstract",
"text": [
"Here we report on miRNPs isolated from neuronal cell lines of mouse and human, and describe 53 novel miRNAs. "
],
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919,
1028
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]
},
{
"id": "3499",
"type": "abstract",
"text": [
"Several of these miRNAs are conserved in divergent organisms, including rat, zebrafish, pufferfish, and the nematode Caenorhabditis elegans. "
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1029,
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},
{
"id": "3500",
"type": "abstract",
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],
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1171,
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},
{
"id": "3501",
"type": "abstract",
"text": [
"These subfamilies comprise multiple copies of miRNAs on different chromosomes, suggesting an important function in the regulation of gene expression. "
],
"offsets": [
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1284,
1436
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]
}
] | [
{
"id": "3502",
"type": "Genes/Proteins",
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73,
79
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]
},
{
"id": "3503",
"type": "Genes/Proteins",
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84,
90
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],
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]
},
{
"id": "3504",
"type": "Genes/Proteins",
"text": [
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[
128,
134
]
],
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"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d71.s0.e2"
}
]
},
{
"id": "3505",
"type": "Relation_Trigger",
"text": [
"associate"
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141,
150
]
],
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"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d71.s0.e3"
}
]
},
{
"id": "3506",
"type": "Non-Specific_miRNAs",
"text": [
"microRNAs"
],
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156,
165
]
],
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{
"db_name": "miRNA-corpus",
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]
},
{
"id": "3507",
"type": "Non-Specific_miRNAs",
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"miRNAs"
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167,
173
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]
},
{
"id": "3508",
"type": "Genes/Proteins",
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"SMN"
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60,
63
]
],
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"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d71.s0.e6"
}
]
},
{
"id": "3509",
"type": "Genes/Proteins",
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"SMN"
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224,
227
]
],
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{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d71.s1.e0"
}
]
},
{
"id": "3510",
"type": "Diseases",
"text": [
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],
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339,
362
]
],
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"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d71.s2.e0"
}
]
},
{
"id": "3511",
"type": "Diseases",
"text": [
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364,
367
]
],
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{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d71.s2.e1"
}
]
},
{
"id": "3512",
"type": "Diseases",
"text": [
"neurodegenerative disease"
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381,
406
]
],
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{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d71.s2.e2"
}
]
},
{
"id": "3513",
"type": "Genes/Proteins",
"text": [
"Survival of Motor Neuron (SMN) protein"
],
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[
472,
510
]
],
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{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d71.s2.e3"
}
]
},
{
"id": "3514",
"type": "Non-Specific_miRNAs",
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"microRNAs"
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567,
576
]
],
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"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d71.s3.e0"
}
]
},
{
"id": "3515",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
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627,
633
]
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{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d71.s4.e0"
}
]
},
{
"id": "3516",
"type": "Relation_Trigger",
"text": [
"candidate region"
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788,
804
]
],
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{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d71.s5.e0"
}
]
},
{
"id": "3517",
"type": "Diseases",
"text": [
"early-onset parkinsonism"
],
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[
834,
858
]
],
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{
"db_name": "miRNA-corpus",
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}
]
},
{
"id": "3518",
"type": "Diseases",
"text": [
"X-linked mental retardation"
],
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[
882,
909
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d71.s5.e2"
}
]
},
{
"id": "3519",
"type": "Specific_miRNAs",
"text": [
"miR-175"
],
"offsets": [
[
774,
781
]
],
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{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d71.s5.e3"
}
]
},
{
"id": "3520",
"type": "Non-Specific_miRNAs",
"text": [
"miRNA"
],
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[
767,
772
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d71.s5.e4"
}
]
},
{
"id": "3521",
"type": "Diseases",
"text": [
"Waisman syndrome"
],
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[
860,
876
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d71.s5.e5"
}
]
},
{
"id": "3522",
"type": "Diseases",
"text": [
"MRX3"
],
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[
911,
915
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d71.s5.e6"
}
]
},
{
"id": "3523",
"type": "Genes/Proteins",
"text": [
"Waisman syndrome"
],
"offsets": [
[
860,
876
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d71.s5.e7"
}
]
},
{
"id": "3524",
"type": "Genes/Proteins",
"text": [
"MRX3"
],
"offsets": [
[
911,
915
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d71.s5.e8"
}
]
},
{
"id": "3525",
"type": "Diseases",
"text": [
"neurologic diseases"
],
"offsets": [
[
813,
832
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d71.s5.e9"
}
]
},
{
"id": "3526",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
[
1020,
1026
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d71.s6.e0"
}
]
},
{
"id": "3527",
"type": "Species",
"text": [
"mouse"
],
"offsets": [
[
981,
986
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d71.s6.e1"
}
]
},
{
"id": "3528",
"type": "Species",
"text": [
"human"
],
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[
991,
996
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d71.s6.e2"
}
]
},
{
"id": "3529",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
[
1046,
1052
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d71.s7.e0"
}
]
},
{
"id": "3530",
"type": "Species",
"text": [
"nematode"
],
"offsets": [
[
1137,
1145
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d71.s7.e1"
}
]
},
{
"id": "3531",
"type": "Species",
"text": [
"rat"
],
"offsets": [
[
1101,
1104
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d71.s7.e2"
}
]
},
{
"id": "3532",
"type": "Species",
"text": [
"zebrafish"
],
"offsets": [
[
1106,
1115
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d71.s7.e3"
}
]
},
{
"id": "3533",
"type": "Species",
"text": [
"Caenorhabditis elegans"
],
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[
1146,
1168
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{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d71.s7.e4"
}
]
},
{
"id": "3534",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
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[
1185,
1191
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],
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{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d71.s8.e0"
}
]
},
{
"id": "3535",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
[
1330,
1336
]
],
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{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d71.s9.e0"
}
]
},
{
"id": "3536",
"type": "Relation_Trigger",
"text": [
"regulation of gene expression"
],
"offsets": [
[
1403,
1432
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],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d71.s9.e1"
}
]
}
] | [] | [] | [
{
"id": "3537",
"type": "Non-Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d71.s0.e4",
"arg2_id": "miRNA-corp.d71.s0.e0",
"normalized": []
},
{
"id": "3538",
"type": "Non-Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d71.s0.e4",
"arg2_id": "miRNA-corp.d71.s0.e1",
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},
{
"id": "3539",
"type": "Non-Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d71.s0.e4",
"arg2_id": "miRNA-corp.d71.s0.e2",
"normalized": []
},
{
"id": "3540",
"type": "Non-Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d71.s0.e4",
"arg2_id": "miRNA-corp.d71.s0.e6",
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},
{
"id": "3541",
"type": "Non-Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d71.s0.e5",
"arg2_id": "miRNA-corp.d71.s0.e0",
"normalized": []
},
{
"id": "3542",
"type": "Non-Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d71.s0.e5",
"arg2_id": "miRNA-corp.d71.s0.e1",
"normalized": []
},
{
"id": "3543",
"type": "Non-Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d71.s0.e5",
"arg2_id": "miRNA-corp.d71.s0.e2",
"normalized": []
},
{
"id": "3544",
"type": "Non-Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d71.s0.e5",
"arg2_id": "miRNA-corp.d71.s0.e6",
"normalized": []
},
{
"id": "3545",
"type": "Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d71.s5.e3",
"arg2_id": "miRNA-corp.d71.s5.e5",
"normalized": []
},
{
"id": "3546",
"type": "Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d71.s5.e3",
"arg2_id": "miRNA-corp.d71.s5.e6",
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},
{
"id": "3547",
"type": "Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d71.s5.e3",
"arg2_id": "miRNA-corp.d71.s5.e7",
"normalized": []
},
{
"id": "3548",
"type": "Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d71.s5.e3",
"arg2_id": "miRNA-corp.d71.s5.e8",
"normalized": []
},
{
"id": "3549",
"type": "Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d71.s5.e3",
"arg2_id": "miRNA-corp.d71.s5.e9",
"normalized": []
},
{
"id": "3550",
"type": "Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d71.s5.e3",
"arg2_id": "miRNA-corp.d71.s5.e1",
"normalized": []
},
{
"id": "3551",
"type": "Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d71.s5.e3",
"arg2_id": "miRNA-corp.d71.s5.e2",
"normalized": []
},
{
"id": "3552",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d71.s5.e4",
"arg2_id": "miRNA-corp.d71.s5.e5",
"normalized": []
},
{
"id": "3553",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d71.s5.e4",
"arg2_id": "miRNA-corp.d71.s5.e6",
"normalized": []
},
{
"id": "3554",
"type": "Non-Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d71.s5.e4",
"arg2_id": "miRNA-corp.d71.s5.e7",
"normalized": []
},
{
"id": "3555",
"type": "Non-Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d71.s5.e4",
"arg2_id": "miRNA-corp.d71.s5.e8",
"normalized": []
},
{
"id": "3556",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d71.s5.e4",
"arg2_id": "miRNA-corp.d71.s5.e9",
"normalized": []
},
{
"id": "3557",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d71.s5.e4",
"arg2_id": "miRNA-corp.d71.s5.e1",
"normalized": []
},
{
"id": "3558",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d71.s5.e4",
"arg2_id": "miRNA-corp.d71.s5.e2",
"normalized": []
}
] |
3586 | miRNA-corp.d72 | [
{
"id": "3560",
"type": "title",
"text": [
"Here we show that human platelets harbor an abundant and diverse array of microRNAs (miRNAs), which are known as key regulators of mRNA translation in other cell types. "
],
"offsets": [
[
0,
169
]
]
},
{
"id": "3561",
"type": "abstract",
"text": [
"Further analyses revealed that platelets contain the Dicer and Argonaute 2 (Ago2) complexes, which function in the processing of exogenous miRNA precursors and the control of specific reporter transcripts, respectively. "
],
"offsets": [
[
170,
390
]
]
},
{
"id": "3562",
"type": "abstract",
"text": [
"Detection of the receptor P2Y(12) mRNA in Ago2 immunoprecipitates suggests that P2Y(12) expression may be subjected to miRNA control in human platelets. "
],
"offsets": [
[
391,
544
]
]
},
{
"id": "3563",
"type": "abstract",
"text": [
"Existence of a microRNA pathway in anucleate platelets. "
],
"offsets": [
[
545,
602
]
]
},
{
"id": "3564",
"type": "abstract",
"text": [
"Platelets have a crucial role in the maintenance of hemostasis as well as in thrombosis and vessel occlusion, which underlie stroke and acute coronary syndromes. "
],
"offsets": [
[
603,
765
]
]
},
{
"id": "3565",
"type": "abstract",
"text": [
"Anucleate platelets contain mRNAs and are capable of protein synthesis, raising the issue of how these mRNAs are regulated. "
],
"offsets": [
[
766,
890
]
]
}
] | [
{
"id": "3566",
"type": "Non-Specific_miRNAs",
"text": [
"microRNAs"
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[
74,
83
]
],
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{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d72.s0.e0"
}
]
},
{
"id": "3567",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
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[
85,
91
]
],
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{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d72.s0.e1"
}
]
},
{
"id": "3568",
"type": "Relation_Trigger",
"text": [
"regulators of mRNA translation"
],
"offsets": [
[
117,
147
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d72.s0.e2"
}
]
},
{
"id": "3569",
"type": "Species",
"text": [
"human"
],
"offsets": [
[
18,
23
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d72.s0.e3"
}
]
},
{
"id": "3570",
"type": "Non-Specific_miRNAs",
"text": [
"miRNA"
],
"offsets": [
[
309,
314
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d72.s1.e0"
}
]
},
{
"id": "3571",
"type": "Genes/Proteins",
"text": [
"Dicer"
],
"offsets": [
[
223,
228
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d72.s1.e1"
}
]
},
{
"id": "3572",
"type": "Genes/Proteins",
"text": [
"Argonaute 2"
],
"offsets": [
[
233,
244
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d72.s1.e2"
}
]
},
{
"id": "3573",
"type": "Genes/Proteins",
"text": [
"Ago2"
],
"offsets": [
[
246,
250
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d72.s1.e3"
}
]
},
{
"id": "3574",
"type": "Non-Specific_miRNAs",
"text": [
"miRNA"
],
"offsets": [
[
510,
515
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d72.s2.e0"
}
]
},
{
"id": "3575",
"type": "Genes/Proteins",
"text": [
"Ago2"
],
"offsets": [
[
433,
437
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d72.s2.e1"
}
]
},
{
"id": "3576",
"type": "Species",
"text": [
"human"
],
"offsets": [
[
527,
532
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d72.s2.e2"
}
]
},
{
"id": "3577",
"type": "Non-Specific_miRNAs",
"text": [
"microRNA"
],
"offsets": [
[
560,
568
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d72.s4.e0"
}
]
},
{
"id": "3578",
"type": "Diseases",
"text": [
"acute coronary syndromes"
],
"offsets": [
[
739,
763
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d72.s5.e0"
}
]
},
{
"id": "3579",
"type": "Diseases",
"text": [
"stroke"
],
"offsets": [
[
728,
734
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d72.s5.e1"
}
]
},
{
"id": "3580",
"type": "Diseases",
"text": [
"thrombosis"
],
"offsets": [
[
680,
690
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d72.s5.e2"
}
]
},
{
"id": "3581",
"type": "Relation_Trigger",
"text": [
"regulated"
],
"offsets": [
[
879,
888
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d72.s6.e0"
}
]
}
] | [] | [] | [
{
"id": "3582",
"type": "Non-Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d72.s1.e0",
"arg2_id": "miRNA-corp.d72.s1.e1",
"normalized": []
},
{
"id": "3583",
"type": "Non-Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d72.s1.e0",
"arg2_id": "miRNA-corp.d72.s1.e2",
"normalized": []
},
{
"id": "3584",
"type": "Non-Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d72.s1.e0",
"arg2_id": "miRNA-corp.d72.s1.e3",
"normalized": []
},
{
"id": "3585",
"type": "Non-Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d72.s2.e0",
"arg2_id": "miRNA-corp.d72.s2.e1",
"normalized": []
}
] |
3637 | miRNA-corp.d73 | [
{
"id": "3587",
"type": "title",
"text": [
"miR-15a and miR-16-1 in cancer: discovery, function and future perspectives. "
],
"offsets": [
[
0,
78
]
]
},
{
"id": "3588",
"type": "abstract",
"text": [
"Expression of these miRNAs inhibits cell proliferation, promotes apoptosis of cancer cells, and suppresses tumorigenicity both in vitro and in vivo. "
],
"offsets": [
[
79,
228
]
]
},
{
"id": "3589",
"type": "abstract",
"text": [
"MicroRNAs (miRNAs) encoded by the miR-15/16 cluster are known to act as tumor suppressors. "
],
"offsets": [
[
229,
320
]
]
},
{
"id": "3590",
"type": "abstract",
"text": [
"Down-regulation of these miRNAs has been reported in chronic lymphocytic lymphoma (CLL), pituitary adenomas, and prostate carcinoma. "
],
"offsets": [
[
321,
454
]
]
},
{
"id": "3591",
"type": "abstract",
"text": [
"miR-15a and miR-16-1 function by targeting multiple oncogenes, including BCL2, MCL1, CCND1, and WNT3A. "
],
"offsets": [
[
455,
558
]
]
},
{
"id": "3592",
"type": "abstract",
"text": [
"This review summarizes the discovery, functions, and clinical relevance of these miRNAs in cancer, particularly CLL. "
],
"offsets": [
[
559,
678
]
]
}
] | [
{
"id": "3593",
"type": "Specific_miRNAs",
"text": [
"miR-16-1"
],
"offsets": [
[
12,
20
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d73.s0.e0"
}
]
},
{
"id": "3594",
"type": "Specific_miRNAs",
"text": [
"miR-15a"
],
"offsets": [
[
0,
7
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d73.s0.e1"
}
]
},
{
"id": "3595",
"type": "Diseases",
"text": [
"cancer"
],
"offsets": [
[
24,
30
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d73.s0.e2"
}
]
},
{
"id": "3596",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
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[
99,
105
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d73.s1.e0"
}
]
},
{
"id": "3597",
"type": "Relation_Trigger",
"text": [
"suppresses"
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[
175,
185
]
],
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{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d73.s1.e1"
}
]
},
{
"id": "3598",
"type": "Relation_Trigger",
"text": [
"inhibits"
],
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[
106,
114
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d73.s1.e2"
}
]
},
{
"id": "3599",
"type": "Diseases",
"text": [
"cancer"
],
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[
157,
163
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d73.s1.e3"
}
]
},
{
"id": "3600",
"type": "Specific_miRNAs",
"text": [
"miR-15/16"
],
"offsets": [
[
263,
272
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d73.s2.e0"
}
]
},
{
"id": "3601",
"type": "Non-Specific_miRNAs",
"text": [
"MicroRNAs"
],
"offsets": [
[
229,
238
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d73.s2.e1"
}
]
},
{
"id": "3602",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
[
240,
246
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d73.s2.e2"
}
]
},
{
"id": "3603",
"type": "Relation_Trigger",
"text": [
"tumor suppressors"
],
"offsets": [
[
301,
318
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d73.s2.e3"
}
]
},
{
"id": "3604",
"type": "Diseases",
"text": [
"chronic lymphocytic lymphoma"
],
"offsets": [
[
374,
402
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d73.s3.e0"
}
]
},
{
"id": "3605",
"type": "Diseases",
"text": [
"CLL"
],
"offsets": [
[
404,
407
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d73.s3.e1"
}
]
},
{
"id": "3606",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
[
346,
352
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d73.s3.e2"
}
]
},
{
"id": "3607",
"type": "Diseases",
"text": [
"pituitary adenomas"
],
"offsets": [
[
410,
428
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d73.s3.e3"
}
]
},
{
"id": "3608",
"type": "Diseases",
"text": [
"prostate carcinoma"
],
"offsets": [
[
434,
452
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d73.s3.e4"
}
]
},
{
"id": "3609",
"type": "Relation_Trigger",
"text": [
"Down-regulation"
],
"offsets": [
[
321,
336
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d73.s3.e5"
}
]
},
{
"id": "3610",
"type": "Specific_miRNAs",
"text": [
"miR-15a"
],
"offsets": [
[
455,
462
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d73.s4.e0"
}
]
},
{
"id": "3611",
"type": "Specific_miRNAs",
"text": [
"miR-16-1"
],
"offsets": [
[
467,
475
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d73.s4.e1"
}
]
},
{
"id": "3612",
"type": "Genes/Proteins",
"text": [
"BCL2"
],
"offsets": [
[
528,
532
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d73.s4.e2"
}
]
},
{
"id": "3613",
"type": "Genes/Proteins",
"text": [
"MCL1"
],
"offsets": [
[
534,
538
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d73.s4.e3"
}
]
},
{
"id": "3614",
"type": "Genes/Proteins",
"text": [
"CCND1"
],
"offsets": [
[
540,
545
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d73.s4.e4"
}
]
},
{
"id": "3615",
"type": "Genes/Proteins",
"text": [
"WNT3A"
],
"offsets": [
[
551,
556
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d73.s4.e5"
}
]
},
{
"id": "3616",
"type": "Relation_Trigger",
"text": [
"targeting"
],
"offsets": [
[
488,
497
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d73.s4.e6"
}
]
},
{
"id": "3617",
"type": "Diseases",
"text": [
"CLL"
],
"offsets": [
[
671,
674
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d73.s5.e0"
}
]
},
{
"id": "3618",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
[
640,
646
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d73.s5.e1"
}
]
},
{
"id": "3619",
"type": "Diseases",
"text": [
"cancer"
],
"offsets": [
[
650,
656
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d73.s5.e2"
}
]
}
] | [] | [] | [
{
"id": "3620",
"type": "Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d73.s0.e0",
"arg2_id": "miRNA-corp.d73.s0.e2",
"normalized": []
},
{
"id": "3621",
"type": "Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d73.s0.e1",
"arg2_id": "miRNA-corp.d73.s0.e2",
"normalized": []
},
{
"id": "3622",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d73.s1.e0",
"arg2_id": "miRNA-corp.d73.s1.e3",
"normalized": []
},
{
"id": "3623",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d73.s3.e2",
"arg2_id": "miRNA-corp.d73.s3.e3",
"normalized": []
},
{
"id": "3624",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d73.s3.e2",
"arg2_id": "miRNA-corp.d73.s3.e4",
"normalized": []
},
{
"id": "3625",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d73.s3.e2",
"arg2_id": "miRNA-corp.d73.s3.e0",
"normalized": []
},
{
"id": "3626",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d73.s3.e2",
"arg2_id": "miRNA-corp.d73.s3.e1",
"normalized": []
},
{
"id": "3627",
"type": "Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d73.s4.e0",
"arg2_id": "miRNA-corp.d73.s4.e2",
"normalized": []
},
{
"id": "3628",
"type": "Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d73.s4.e0",
"arg2_id": "miRNA-corp.d73.s4.e3",
"normalized": []
},
{
"id": "3629",
"type": "Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d73.s4.e0",
"arg2_id": "miRNA-corp.d73.s4.e4",
"normalized": []
},
{
"id": "3630",
"type": "Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d73.s4.e0",
"arg2_id": "miRNA-corp.d73.s4.e5",
"normalized": []
},
{
"id": "3631",
"type": "Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d73.s4.e1",
"arg2_id": "miRNA-corp.d73.s4.e2",
"normalized": []
},
{
"id": "3632",
"type": "Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d73.s4.e1",
"arg2_id": "miRNA-corp.d73.s4.e3",
"normalized": []
},
{
"id": "3633",
"type": "Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d73.s4.e1",
"arg2_id": "miRNA-corp.d73.s4.e4",
"normalized": []
},
{
"id": "3634",
"type": "Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d73.s4.e1",
"arg2_id": "miRNA-corp.d73.s4.e5",
"normalized": []
},
{
"id": "3635",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d73.s5.e1",
"arg2_id": "miRNA-corp.d73.s5.e0",
"normalized": []
},
{
"id": "3636",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d73.s5.e1",
"arg2_id": "miRNA-corp.d73.s5.e2",
"normalized": []
}
] |
3670 | miRNA-corp.d74 | [
{
"id": "3638",
"type": "title",
"text": [
"Molecular and cellular neurobiological studies of the miRNAs in neurodegeneration represent the exploration of a new Frontier of miRNAs biology and the potential development of new diagnostic tests and genetic therapies for neurodegenerative diseases. "
],
"offsets": [
[
0,
254
]
]
},
{
"id": "3639",
"type": "abstract",
"text": [
"MiRNA studies in neurobiology showed their involvement in synaptic plasticity and brain diseases. "
],
"offsets": [
[
255,
353
]
]
},
{
"id": "3640",
"type": "abstract",
"text": [
"In this review ,correlations between miRNA-mediated gene silencing and Alzheimer's, Parkinson's, and other neurodegenerative diseases will be discussed. "
],
"offsets": [
[
354,
507
]
]
},
{
"id": "3641",
"type": "abstract",
"text": [
"In few years our understanding of microRNA (miRNA) biogenesis, molecular mechanisms by which miRNAs regulate gene expression, and the functional roles of miRNAs has been expanded. "
],
"offsets": [
[
508,
688
]
]
},
{
"id": "3642",
"type": "abstract",
"text": [
"Interestingly, numerous miRNAs are expressed in a spatially and temporally controlled manner in the nervous system, suggesting that their posttrascriptional regulation may be particularly relevant in neural development and function. "
],
"offsets": [
[
689,
922
]
]
},
{
"id": "3643",
"type": "abstract",
"text": [
"Searching for MIND: microRNAs in neurodegenerative diseases. "
],
"offsets": [
[
923,
985
]
]
}
] | [
{
"id": "3644",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
[
54,
60
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d74.s0.e0"
}
]
},
{
"id": "3645",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
[
129,
135
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d74.s0.e1"
}
]
},
{
"id": "3646",
"type": "Diseases",
"text": [
"neurodegenerative diseases"
],
"offsets": [
[
224,
250
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d74.s0.e2"
}
]
},
{
"id": "3647",
"type": "Non-Specific_miRNAs",
"text": [
"MiRNA"
],
"offsets": [
[
255,
260
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d74.s1.e0"
}
]
},
{
"id": "3648",
"type": "Diseases",
"text": [
"brain diseases"
],
"offsets": [
[
337,
351
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d74.s1.e1"
}
]
},
{
"id": "3649",
"type": "Diseases",
"text": [
"Alzheimer's"
],
"offsets": [
[
425,
436
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d74.s2.e0"
}
]
},
{
"id": "3650",
"type": "Diseases",
"text": [
"Parkinson's"
],
"offsets": [
[
438,
449
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d74.s2.e1"
}
]
},
{
"id": "3651",
"type": "Relation_Trigger",
"text": [
"correlations"
],
"offsets": [
[
370,
382
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d74.s2.e2"
}
]
},
{
"id": "3652",
"type": "Non-Specific_miRNAs",
"text": [
"miRNA"
],
"offsets": [
[
391,
396
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d74.s2.e3"
}
]
},
{
"id": "3653",
"type": "Diseases",
"text": [
"neurodegenerative diseases"
],
"offsets": [
[
461,
487
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d74.s2.e4"
}
]
},
{
"id": "3654",
"type": "Non-Specific_miRNAs",
"text": [
"microRNA"
],
"offsets": [
[
542,
550
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d74.s3.e0"
}
]
},
{
"id": "3655",
"type": "Non-Specific_miRNAs",
"text": [
"miRNA"
],
"offsets": [
[
552,
557
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d74.s3.e1"
}
]
},
{
"id": "3656",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
[
601,
607
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d74.s3.e2"
}
]
},
{
"id": "3657",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
[
662,
668
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d74.s3.e3"
}
]
},
{
"id": "3658",
"type": "Relation_Trigger",
"text": [
"regulate gene expression"
],
"offsets": [
[
608,
632
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d74.s3.e4"
}
]
},
{
"id": "3659",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
[
713,
719
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d74.s4.e0"
}
]
},
{
"id": "3660",
"type": "Relation_Trigger",
"text": [
"regulation"
],
"offsets": [
[
846,
856
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d74.s4.e1"
}
]
},
{
"id": "3661",
"type": "Non-Specific_miRNAs",
"text": [
"microRNAs"
],
"offsets": [
[
943,
952
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d74.s5.e0"
}
]
},
{
"id": "3662",
"type": "Diseases",
"text": [
"neurodegenerative diseases"
],
"offsets": [
[
956,
982
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d74.s5.e1"
}
]
}
] | [] | [] | [
{
"id": "3663",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d74.s0.e1",
"arg2_id": "miRNA-corp.d74.s0.e2",
"normalized": []
},
{
"id": "3664",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d74.s0.e0",
"arg2_id": "miRNA-corp.d74.s0.e2",
"normalized": []
},
{
"id": "3665",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d74.s1.e0",
"arg2_id": "miRNA-corp.d74.s1.e1",
"normalized": []
},
{
"id": "3666",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d74.s2.e3",
"arg2_id": "miRNA-corp.d74.s2.e4",
"normalized": []
},
{
"id": "3667",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d74.s2.e3",
"arg2_id": "miRNA-corp.d74.s2.e0",
"normalized": []
},
{
"id": "3668",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d74.s2.e3",
"arg2_id": "miRNA-corp.d74.s2.e1",
"normalized": []
},
{
"id": "3669",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d74.s5.e0",
"arg2_id": "miRNA-corp.d74.s5.e1",
"normalized": []
}
] |
3681 | miRNA-corp.d75 | [
{
"id": "3671",
"type": "abstract",
"text": [
"As examples, a detailed description is given on the regeneration of functional sweat glands on burned skin as well as neural cells in middle cerebral artery occlusion (MCAO) animals upon MSC transplantation. "
],
"offsets": [
[
0,
208
]
]
},
{
"id": "3672",
"type": "abstract",
"text": [
"The mechanisms of therapeutic effects of MSCs are attributed to their ability to migrate along chemokine gradients, differentiate into tissue-specific cells, enhance angiogenesis of wound tissue and regulate immune response. "
],
"offsets": [
[
209,
434
]
]
},
{
"id": "3673",
"type": "abstract",
"text": [
"Special attention is given to miRNA expression and its relationship with the characteristics of MSCs. "
],
"offsets": [
[
435,
537
]
]
},
{
"id": "3674",
"type": "abstract",
"text": [
"WHAT THE READER WILL GAIN: The gene expression profiles for mRNA, protein, microRNA and cell surface marker of MSCs are summarized. "
],
"offsets": [
[
538,
670
]
]
}
] | [
{
"id": "3675",
"type": "Diseases",
"text": [
"middle cerebral artery occlusion"
],
"offsets": [
[
134,
166
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d75.s4.e0"
}
]
},
{
"id": "3676",
"type": "Diseases",
"text": [
"MCAO"
],
"offsets": [
[
168,
172
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d75.s4.e1"
}
]
},
{
"id": "3677",
"type": "Relation_Trigger",
"text": [
"regulate"
],
"offsets": [
[
408,
416
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d75.s5.e0"
}
]
},
{
"id": "3678",
"type": "Diseases",
"text": [
"wound"
],
"offsets": [
[
391,
396
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d75.s5.e1"
}
]
},
{
"id": "3679",
"type": "Non-Specific_miRNAs",
"text": [
"miRNA"
],
"offsets": [
[
465,
470
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d75.s6.e0"
}
]
},
{
"id": "3680",
"type": "Non-Specific_miRNAs",
"text": [
"microRNA"
],
"offsets": [
[
613,
621
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d75.s7.e0"
}
]
}
] | [] | [] | [] |
3733 | miRNA-corp.d76 | [
{
"id": "3682",
"type": "title",
"text": [
"MicroRNA expression in the blood and brain of rats subjected to transient focal ischemia by middle cerebral artery occlusion. "
],
"offsets": [
[
0,
127
]
]
},
{
"id": "3683",
"type": "abstract",
"text": [
"BACKGROUND AND PURPOSE: Several hundred small RNAs called microRNAs (miRNAs) have been identified and characterized from various organisms, including humans. "
],
"offsets": [
[
128,
286
]
]
},
{
"id": "3684",
"type": "abstract",
"text": [
"In humans, some of these miRNAs have been found to regulate (patho)physiologic conditions such as tumor progression/regression, cholesterol and glucose homeostasis, etc. "
],
"offsets": [
[
287,
457
]
]
},
{
"id": "3685",
"type": "abstract",
"text": [
"In this report, we present data on the miRNAs expressed under ischemic conditions in both the brain and blood of rats subjected to middle cerebral artery occlusion (MCAo). "
],
"offsets": [
[
458,
630
]
]
},
{
"id": "3686",
"type": "abstract",
"text": [
"METHODS: Sprague-Dawley rats subjected to MCAo were reperfused for either 24 or 48 hours, and both blood and brain samples were harvested. "
],
"offsets": [
[
631,
770
]
]
},
{
"id": "3687",
"type": "abstract",
"text": [
"miRNA expression profiling and oligonucleotide microarray were carried out, and the data were validated by quantitative real-time polymerase chain reaction and correlated with published data on protein and gene expression in MCAo rats. "
],
"offsets": [
[
771,
1007
]
]
},
{
"id": "3688",
"type": "abstract",
"text": [
"RESULTS: We report here for the first time the involvement of miRNA regulation in brain pathogenesis associated with MCAo. "
],
"offsets": [
[
1008,
1131
]
]
},
{
"id": "3689",
"type": "abstract",
"text": [
"Comparison with the corresponding DNA microarray data revealed that the target mRNA expression is correlated with the regulation of miRNA. "
],
"offsets": [
[
1132,
1271
]
]
},
{
"id": "3690",
"type": "abstract",
"text": [
"We have also provided evidence that some of the miRNAs that are highly expressed in the ischemic brain can be detected in blood samples. "
],
"offsets": [
[
1272,
1409
]
]
},
{
"id": "3691",
"type": "abstract",
"text": [
"CONCLUSIONS: Further studies are needed to evaluate the possible use of miRNAs as biomarkers in stroke and related pathologies. "
],
"offsets": [
[
1410,
1540
]
]
}
] | [
{
"id": "3692",
"type": "Non-Specific_miRNAs",
"text": [
"MicroRNA"
],
"offsets": [
[
0,
8
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d76.s0.e0"
}
]
},
{
"id": "3693",
"type": "Diseases",
"text": [
"ischemia"
],
"offsets": [
[
80,
88
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d76.s0.e1"
}
]
},
{
"id": "3694",
"type": "Diseases",
"text": [
"middle cerebral artery occlusion"
],
"offsets": [
[
92,
124
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d76.s0.e2"
}
]
},
{
"id": "3695",
"type": "Species",
"text": [
"rats"
],
"offsets": [
[
46,
50
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d76.s0.e3"
}
]
},
{
"id": "3696",
"type": "Non-Specific_miRNAs",
"text": [
"microRNAs"
],
"offsets": [
[
186,
195
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d76.s1.e0"
}
]
},
{
"id": "3697",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
[
197,
203
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d76.s1.e1"
}
]
},
{
"id": "3698",
"type": "Species",
"text": [
"humans"
],
"offsets": [
[
278,
284
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d76.s1.e2"
}
]
},
{
"id": "3699",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
[
312,
318
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d76.s2.e0"
}
]
},
{
"id": "3700",
"type": "Relation_Trigger",
"text": [
"regulate"
],
"offsets": [
[
338,
346
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d76.s2.e1"
}
]
},
{
"id": "3701",
"type": "Diseases",
"text": [
"tumor progression"
],
"offsets": [
[
385,
402
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d76.s2.e2"
}
]
},
{
"id": "3702",
"type": "Species",
"text": [
"humans"
],
"offsets": [
[
290,
296
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d76.s2.e3"
}
]
},
{
"id": "3703",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
[
497,
503
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d76.s3.e0"
}
]
},
{
"id": "3704",
"type": "Diseases",
"text": [
"middle cerebral artery occlusion"
],
"offsets": [
[
589,
621
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d76.s3.e1"
}
]
},
{
"id": "3705",
"type": "Diseases",
"text": [
"MCAo"
],
"offsets": [
[
623,
627
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d76.s3.e2"
}
]
},
{
"id": "3706",
"type": "Species",
"text": [
"rats"
],
"offsets": [
[
571,
575
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d76.s3.e3"
}
]
},
{
"id": "3707",
"type": "Diseases",
"text": [
"MCAo"
],
"offsets": [
[
673,
677
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d76.s4.e0"
}
]
},
{
"id": "3708",
"type": "Species",
"text": [
"rats"
],
"offsets": [
[
655,
659
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d76.s4.e1"
}
]
},
{
"id": "3709",
"type": "Non-Specific_miRNAs",
"text": [
"miRNA"
],
"offsets": [
[
771,
776
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d76.s5.e0"
}
]
},
{
"id": "3710",
"type": "Diseases",
"text": [
"MCAo"
],
"offsets": [
[
996,
1000
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d76.s5.e1"
}
]
},
{
"id": "3711",
"type": "Species",
"text": [
"rats"
],
"offsets": [
[
1001,
1005
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d76.s5.e2"
}
]
},
{
"id": "3712",
"type": "Relation_Trigger",
"text": [
"correlated"
],
"offsets": [
[
931,
941
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d76.s5.e3"
}
]
},
{
"id": "3713",
"type": "Non-Specific_miRNAs",
"text": [
"miRNA"
],
"offsets": [
[
1070,
1075
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d76.s6.e0"
}
]
},
{
"id": "3714",
"type": "Diseases",
"text": [
"MCAo"
],
"offsets": [
[
1125,
1129
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d76.s6.e1"
}
]
},
{
"id": "3715",
"type": "Relation_Trigger",
"text": [
"regulation"
],
"offsets": [
[
1076,
1086
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d76.s6.e2"
}
]
},
{
"id": "3716",
"type": "Relation_Trigger",
"text": [
"associated"
],
"offsets": [
[
1109,
1119
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d76.s6.e3"
}
]
},
{
"id": "3717",
"type": "Non-Specific_miRNAs",
"text": [
"miRNA"
],
"offsets": [
[
1264,
1269
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d76.s7.e0"
}
]
},
{
"id": "3718",
"type": "Relation_Trigger",
"text": [
"target"
],
"offsets": [
[
1204,
1210
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d76.s7.e1"
}
]
},
{
"id": "3719",
"type": "Relation_Trigger",
"text": [
"regulation"
],
"offsets": [
[
1250,
1260
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d76.s7.e2"
}
]
},
{
"id": "3720",
"type": "Relation_Trigger",
"text": [
"expression is correlated"
],
"offsets": [
[
1216,
1240
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d76.s7.e3"
}
]
},
{
"id": "3721",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
[
1320,
1326
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d76.s8.e0"
}
]
},
{
"id": "3722",
"type": "Relation_Trigger",
"text": [
"highly expressed"
],
"offsets": [
[
1336,
1352
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d76.s8.e1"
}
]
},
{
"id": "3723",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
[
1482,
1488
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d76.s9.e0"
}
]
},
{
"id": "3724",
"type": "Diseases",
"text": [
"stroke"
],
"offsets": [
[
1506,
1512
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d76.s9.e1"
}
]
}
] | [] | [] | [
{
"id": "3725",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d76.s0.e0",
"arg2_id": "miRNA-corp.d76.s0.e1",
"normalized": []
},
{
"id": "3726",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d76.s0.e0",
"arg2_id": "miRNA-corp.d76.s0.e2",
"normalized": []
},
{
"id": "3727",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d76.s2.e0",
"arg2_id": "miRNA-corp.d76.s2.e2",
"normalized": []
},
{
"id": "3728",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d76.s3.e0",
"arg2_id": "miRNA-corp.d76.s3.e1",
"normalized": []
},
{
"id": "3729",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d76.s3.e0",
"arg2_id": "miRNA-corp.d76.s3.e2",
"normalized": []
},
{
"id": "3730",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d76.s5.e0",
"arg2_id": "miRNA-corp.d76.s5.e1",
"normalized": []
},
{
"id": "3731",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d76.s6.e0",
"arg2_id": "miRNA-corp.d76.s6.e1",
"normalized": []
},
{
"id": "3732",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d76.s9.e0",
"arg2_id": "miRNA-corp.d76.s9.e1",
"normalized": []
}
] |
3750 | miRNA-corp.d77 | [
{
"id": "3734",
"type": "title",
"text": [
"[A study on miRNA alternation after H2O2-induced PC12 cell apoptosis using microarray technique]. "
],
"offsets": [
[
0,
99
]
]
},
{
"id": "3735",
"type": "abstract",
"text": [
"OBJECTIVE: To screen the differentially expressed microRNAs(miRNA) between H2O2-induced PC12 cell apoptosis and normal PC12 cells with microarray chips. "
],
"offsets": [
[
100,
253
]
]
},
{
"id": "3736",
"type": "abstract",
"text": [
"Of the 46 miRNAs in the H2O2 treated groups, 39 were similar to that of the control group and 6 were significantly down-regulated. "
],
"offsets": [
[
254,
385
]
]
},
{
"id": "3737",
"type": "abstract",
"text": [
"CONCLUSION: Our preliminary data may provide a new potential foundation for further study of pathogenesis and its treatment of nerve cell apoptosis caused by cerebral ischemia reperfusion. "
],
"offsets": [
[
386,
577
]
]
},
{
"id": "3738",
"type": "abstract",
"text": [
"Expression of 68 miRNAs and 46 miRNAs were detected in both control group and the H2O2 treated groups. "
],
"offsets": [
[
578,
681
]
]
},
{
"id": "3739",
"type": "abstract",
"text": [
"miRNAs were isolated from control (0 nmol/L H2O2) and H2O2 treated (at concentrations of 50, 100, 200, and 400 nmol/L H2O2, respectively) groups of the PC12 cells, respectively, and were then detected and analyzed by microarray chips. "
],
"offsets": [
[
682,
917
]
]
}
] | [
{
"id": "3740",
"type": "Non-Specific_miRNAs",
"text": [
"miRNA"
],
"offsets": [
[
12,
17
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d77.s0.e0"
}
]
},
{
"id": "3741",
"type": "Non-Specific_miRNAs",
"text": [
"microRNAs"
],
"offsets": [
[
150,
159
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d77.s2.e0"
}
]
},
{
"id": "3742",
"type": "Non-Specific_miRNAs",
"text": [
"miRNA"
],
"offsets": [
[
160,
165
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d77.s2.e1"
}
]
},
{
"id": "3743",
"type": "Relation_Trigger",
"text": [
"differentially expressed"
],
"offsets": [
[
125,
149
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d77.s2.e2"
}
]
},
{
"id": "3744",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
[
264,
270
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d77.s3.e0"
}
]
},
{
"id": "3745",
"type": "Relation_Trigger",
"text": [
"down-regulated"
],
"offsets": [
[
369,
383
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d77.s3.e1"
}
]
},
{
"id": "3746",
"type": "Diseases",
"text": [
"cerebral ischemia reperfusion"
],
"offsets": [
[
544,
573
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d77.s4.e0"
}
]
},
{
"id": "3747",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
[
595,
601
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d77.s6.e0"
}
]
},
{
"id": "3748",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
[
609,
615
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d77.s6.e1"
}
]
},
{
"id": "3749",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
[
682,
688
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d77.s7.e0"
}
]
}
] | [] | [] | [] |
3801 | miRNA-corp.d78 | [
{
"id": "3751",
"type": "title",
"text": [
"CONCLUSIONS: The irregularity of prolactin secretion in patients with NPG is not dependant on the presence of a pituitary tumour which suggests that a hypothalamic dysfunction underlies this condition. "
],
"offsets": [
[
0,
202
]
]
},
{
"id": "3752",
"type": "abstract",
"text": [
"An irregular secretion and a higher daily mass production of prolactin in patients with NPG could explain both galactorrhea and infertility. "
],
"offsets": [
[
203,
346
]
]
},
{
"id": "3753",
"type": "abstract",
"text": [
"BACKGROUND: Abnormal frequency and pulse amplitud of prolactin secretion in micro and macroprolactinomas has been atributed to a dysfunctional tumoral lactotrope. "
],
"offsets": [
[
347,
510
]
]
},
{
"id": "3754",
"type": "abstract",
"text": [
"[Irregular secretion of prolactin in infertile women with normoprolactinemic galactorrhea]. "
],
"offsets": [
[
511,
604
]
]
},
{
"id": "3755",
"type": "abstract",
"text": [
"The regularity of prolactin secretion has not been studied with cuantitative methods in patients with normoprolactinemic galactorrhea (NPG) which could be considered an entity that precedes non tumoral and tumoral hyperprolactinemia. "
],
"offsets": [
[
605,
839
]
]
},
{
"id": "3756",
"type": "abstract",
"text": [
"Previous evidence suggests that non tumoral hyperprolactinemia is caused by a hypothalamic dysfunction. "
],
"offsets": [
[
840,
944
]
]
},
{
"id": "3757",
"type": "abstract",
"text": [
"PATIENTS AND METHODS: A transversal-comparative study was carried out in 6 infertile women with normoprolactinemic galactorrhea and 4 healthy women as controls. "
],
"offsets": [
[
945,
1106
]
]
},
{
"id": "3758",
"type": "abstract",
"text": [
"Objective: To analyze the 24-hour prolactin secretion pattern and its secretion regularity in a group of infertile women with normoprolactinemic galatorea. "
],
"offsets": [
[
1107,
1263
]
]
},
{
"id": "3759",
"type": "abstract",
"text": [
"RESULTS: Blunting of the nyctohemeral rythm and nocturn hyperprolactinaemia occurred in patients with normoprolactinemic galactorrhea (NPG). "
],
"offsets": [
[
1264,
1405
]
]
},
{
"id": "3760",
"type": "abstract",
"text": [
"The 24 hour prolactin profile, the ratio night time mean concentration/daytime mean concentrattion (NM/DM ratio) and apparent entropy (Ap En, Ap En ratio) were compared in the two groups. "
],
"offsets": [
[
1406,
1594
]
]
},
{
"id": "3761",
"type": "abstract",
"text": [
"Higher irregularity of prolactin secretion was found in patients with NPG (ApEn: 0.853 +/- 0.158 vs 0.608 +/- 0.171, p=0.04; Ap En ratio: 0.839 +/- 0.11 vs 0.661 +/- 0.14; p=0.04). "
],
"offsets": [
[
1595,
1776
]
]
},
{
"id": "3762",
"type": "abstract",
"text": [
"NM/DM ratio was lower in patients with NPG than in controls (1.28 +/- 0.25 vs. 1.75 +/- 0.05; p= 0.01). "
],
"offsets": [
[
1777,
1881
]
]
}
] | [
{
"id": "3763",
"type": "Diseases",
"text": [
"hypothalamic dysfunction"
],
"offsets": [
[
151,
175
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d78.s0.e0"
}
]
},
{
"id": "3764",
"type": "Genes/Proteins",
"text": [
"prolactin"
],
"offsets": [
[
33,
42
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d78.s0.e1"
}
]
},
{
"id": "3765",
"type": "Diseases",
"text": [
"pituitary tumour"
],
"offsets": [
[
112,
128
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d78.s0.e2"
}
]
},
{
"id": "3766",
"type": "Diseases",
"text": [
"NPG"
],
"offsets": [
[
70,
73
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d78.s0.e3"
}
]
},
{
"id": "3767",
"type": "Species",
"text": [
"patients"
],
"offsets": [
[
56,
64
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d78.s0.e4"
}
]
},
{
"id": "3768",
"type": "Diseases",
"text": [
"NPG"
],
"offsets": [
[
291,
294
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d78.s1.e0"
}
]
},
{
"id": "3769",
"type": "Diseases",
"text": [
"infertility"
],
"offsets": [
[
331,
342
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d78.s1.e1"
}
]
},
{
"id": "3770",
"type": "Diseases",
"text": [
"galactorrhea"
],
"offsets": [
[
314,
326
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d78.s1.e2"
}
]
},
{
"id": "3771",
"type": "Genes/Proteins",
"text": [
"prolactin"
],
"offsets": [
[
264,
273
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d78.s1.e3"
}
]
},
{
"id": "3772",
"type": "Species",
"text": [
"patients"
],
"offsets": [
[
277,
285
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d78.s1.e4"
}
]
},
{
"id": "3773",
"type": "Genes/Proteins",
"text": [
"prolactin"
],
"offsets": [
[
400,
409
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d78.s2.e0"
}
]
},
{
"id": "3774",
"type": "Diseases",
"text": [
"macroprolactinomas"
],
"offsets": [
[
433,
451
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d78.s2.e1"
}
]
},
{
"id": "3775",
"type": "Genes/Proteins",
"text": [
"prolactin"
],
"offsets": [
[
535,
544
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d78.s3.e0"
}
]
},
{
"id": "3776",
"type": "Diseases",
"text": [
"normoprolactinemic galactorrhea"
],
"offsets": [
[
569,
600
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d78.s3.e1"
}
]
},
{
"id": "3777",
"type": "Species",
"text": [
"women"
],
"offsets": [
[
558,
563
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d78.s3.e2"
}
]
},
{
"id": "3778",
"type": "Diseases",
"text": [
"tumoral hyperprolactinemia"
],
"offsets": [
[
811,
837
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d78.s4.e0"
}
]
},
{
"id": "3779",
"type": "Diseases",
"text": [
"normoprolactinemic galactorrhea"
],
"offsets": [
[
707,
738
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d78.s4.e1"
}
]
},
{
"id": "3780",
"type": "Diseases",
"text": [
"NPG"
],
"offsets": [
[
740,
743
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d78.s4.e2"
}
]
},
{
"id": "3781",
"type": "Genes/Proteins",
"text": [
"prolactin"
],
"offsets": [
[
623,
632
]
],
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{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d78.s4.e3"
}
]
},
{
"id": "3782",
"type": "Species",
"text": [
"patients"
],
"offsets": [
[
693,
701
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d78.s4.e4"
}
]
},
{
"id": "3783",
"type": "Diseases",
"text": [
"hypothalamic dysfunction"
],
"offsets": [
[
918,
942
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d78.s5.e0"
}
]
},
{
"id": "3784",
"type": "Diseases",
"text": [
"non tumoral hyperprolactinemia"
],
"offsets": [
[
872,
902
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d78.s5.e1"
}
]
},
{
"id": "3785",
"type": "Diseases",
"text": [
"normoprolactinemic galactorrhea"
],
"offsets": [
[
1041,
1072
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d78.s6.e0"
}
]
},
{
"id": "3786",
"type": "Species",
"text": [
"women"
],
"offsets": [
[
1030,
1035
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d78.s6.e1"
}
]
},
{
"id": "3787",
"type": "Species",
"text": [
"women"
],
"offsets": [
[
1087,
1092
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d78.s6.e2"
}
]
},
{
"id": "3788",
"type": "Species",
"text": [
"PATIENTS"
],
"offsets": [
[
945,
953
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d78.s6.e3"
}
]
},
{
"id": "3789",
"type": "Genes/Proteins",
"text": [
"prolactin"
],
"offsets": [
[
1141,
1150
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d78.s7.e0"
}
]
},
{
"id": "3790",
"type": "Species",
"text": [
"women"
],
"offsets": [
[
1222,
1227
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d78.s7.e1"
}
]
},
{
"id": "3791",
"type": "Diseases",
"text": [
"nocturn hyperprolactinaemia"
],
"offsets": [
[
1312,
1339
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d78.s8.e0"
}
]
},
{
"id": "3792",
"type": "Diseases",
"text": [
"normoprolactinemic galactorrhea"
],
"offsets": [
[
1366,
1397
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d78.s8.e1"
}
]
},
{
"id": "3793",
"type": "Diseases",
"text": [
"NPG"
],
"offsets": [
[
1399,
1402
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d78.s8.e2"
}
]
},
{
"id": "3794",
"type": "Species",
"text": [
"patients"
],
"offsets": [
[
1352,
1360
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d78.s8.e3"
}
]
},
{
"id": "3795",
"type": "Genes/Proteins",
"text": [
"prolactin"
],
"offsets": [
[
1418,
1427
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d78.s9.e0"
}
]
},
{
"id": "3796",
"type": "Diseases",
"text": [
"NPG"
],
"offsets": [
[
1665,
1668
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d78.s10.e0"
}
]
},
{
"id": "3797",
"type": "Genes/Proteins",
"text": [
"prolactin"
],
"offsets": [
[
1618,
1627
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d78.s10.e1"
}
]
},
{
"id": "3798",
"type": "Species",
"text": [
"patients"
],
"offsets": [
[
1651,
1659
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d78.s10.e2"
}
]
},
{
"id": "3799",
"type": "Diseases",
"text": [
"NPG"
],
"offsets": [
[
1816,
1819
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d78.s11.e0"
}
]
},
{
"id": "3800",
"type": "Species",
"text": [
"patients"
],
"offsets": [
[
1802,
1810
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d78.s11.e1"
}
]
}
] | [] | [] | [] |
3837 | miRNA-corp.d79 | [
{
"id": "3802",
"type": "title",
"text": [
"Alteration of miRNA expression by disease and insult also holds the potential for improved diagnostic tools. "
],
"offsets": [
[
0,
109
]
]
},
{
"id": "3803",
"type": "abstract",
"text": [
"Finally, miRNAs have been shown to control cellular proliferation and specification, suggesting that manipulation of miRNAs in cultured cells could result in more convenient generation of pure cell populations for transplantation. "
],
"offsets": [
[
110,
343
]
]
},
{
"id": "3804",
"type": "abstract",
"text": [
"miRNAs appear to be dysregulated in a number of neurodegenerative diseases, developmental disorders, and as a result of stroke. "
],
"offsets": [
[
344,
472
]
]
},
{
"id": "3805",
"type": "abstract",
"text": [
"MicroRNAS (miRNAs) have been suggested to play important roles in the central nervous system during development as well as disease. "
],
"offsets": [
[
473,
605
]
]
},
{
"id": "3806",
"type": "abstract",
"text": [
"The therapeutic potential of microRNAs in nervous system damage, degeneration, and repair. "
],
"offsets": [
[
606,
698
]
]
},
{
"id": "3807",
"type": "abstract",
"text": [
"Artificial miRNAs have also been generated for the repression of specific transcripts. "
],
"offsets": [
[
699,
786
]
]
},
{
"id": "3808",
"type": "abstract",
"text": [
"Both viral delivery and administration of modified oligonucleotides mimicking or inhibiting specific miRNAs have been effective in model systems. "
],
"offsets": [
[
787,
933
]
]
},
{
"id": "3809",
"type": "abstract",
"text": [
"Recent findings suggest that it may eventually be possible to treat some neurological disorders by restoring or inhibiting miRNAs altered by disease pathology. "
],
"offsets": [
[
934,
1094
]
]
},
{
"id": "3810",
"type": "abstract",
"text": [
"Each miRNA has the ability to regulate hundreds of messenger RNA transcripts, both by causing degradation of the mRNA and by inhibition of protein translation. "
],
"offsets": [
[
1095,
1255
]
]
}
] | [
{
"id": "3811",
"type": "Non-Specific_miRNAs",
"text": [
"miRNA"
],
"offsets": [
[
14,
19
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d79.s0.e0"
}
]
},
{
"id": "3812",
"type": "Relation_Trigger",
"text": [
"Alteration of miRNA expression"
],
"offsets": [
[
0,
30
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d79.s0.e1"
}
]
},
{
"id": "3813",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
[
119,
125
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d79.s1.e0"
}
]
},
{
"id": "3814",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
[
227,
233
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d79.s1.e1"
}
]
},
{
"id": "3815",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
[
344,
350
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d79.s2.e0"
}
]
},
{
"id": "3816",
"type": "Diseases",
"text": [
"stroke"
],
"offsets": [
[
464,
470
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d79.s2.e1"
}
]
},
{
"id": "3817",
"type": "Diseases",
"text": [
"developmental disorders"
],
"offsets": [
[
420,
443
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d79.s2.e2"
}
]
},
{
"id": "3818",
"type": "Relation_Trigger",
"text": [
"dysregulated"
],
"offsets": [
[
364,
376
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d79.s2.e3"
}
]
},
{
"id": "3819",
"type": "Diseases",
"text": [
"neurodegenerative diseases"
],
"offsets": [
[
392,
418
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d79.s2.e4"
}
]
},
{
"id": "3820",
"type": "Non-Specific_miRNAs",
"text": [
"MicroRNAS"
],
"offsets": [
[
473,
482
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d79.s3.e0"
}
]
},
{
"id": "3821",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
[
484,
490
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d79.s3.e1"
}
]
},
{
"id": "3822",
"type": "Non-Specific_miRNAs",
"text": [
"microRNAs"
],
"offsets": [
[
635,
644
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d79.s4.e0"
}
]
},
{
"id": "3823",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
[
710,
716
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d79.s5.e0"
}
]
},
{
"id": "3824",
"type": "Relation_Trigger",
"text": [
"repression"
],
"offsets": [
[
750,
760
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d79.s5.e1"
}
]
},
{
"id": "3825",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
[
888,
894
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d79.s6.e0"
}
]
},
{
"id": "3826",
"type": "Relation_Trigger",
"text": [
"inhibiting"
],
"offsets": [
[
868,
878
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d79.s6.e1"
}
]
},
{
"id": "3827",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
[
1057,
1063
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d79.s7.e0"
}
]
},
{
"id": "3828",
"type": "Relation_Trigger",
"text": [
"inhibiting"
],
"offsets": [
[
1046,
1056
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d79.s7.e1"
}
]
},
{
"id": "3829",
"type": "Diseases",
"text": [
"neurological disorders"
],
"offsets": [
[
1007,
1029
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d79.s7.e2"
}
]
},
{
"id": "3830",
"type": "Non-Specific_miRNAs",
"text": [
"miRNA"
],
"offsets": [
[
1100,
1105
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d79.s8.e0"
}
]
},
{
"id": "3831",
"type": "Relation_Trigger",
"text": [
"regulate"
],
"offsets": [
[
1125,
1133
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d79.s8.e1"
}
]
},
{
"id": "3832",
"type": "Relation_Trigger",
"text": [
"inhibition of protein translation"
],
"offsets": [
[
1220,
1253
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d79.s8.e2"
}
]
}
] | [] | [] | [
{
"id": "3833",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d79.s2.e0",
"arg2_id": "miRNA-corp.d79.s2.e1",
"normalized": []
},
{
"id": "3834",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d79.s2.e0",
"arg2_id": "miRNA-corp.d79.s2.e2",
"normalized": []
},
{
"id": "3835",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d79.s2.e0",
"arg2_id": "miRNA-corp.d79.s2.e4",
"normalized": []
},
{
"id": "3836",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d79.s7.e0",
"arg2_id": "miRNA-corp.d79.s7.e2",
"normalized": []
}
] |
3848 | miRNA-corp.d80 | [
{
"id": "3838",
"type": "abstract",
"text": [
"METHODS: A controlled study of patients with left (LTLE) or right (RTLE) TLE. "
],
"offsets": [
[
0,
78
]
]
},
{
"id": "3839",
"type": "abstract",
"text": [
"AIM: To assess the hippocampal function in remote orientation and visuospatial memory in patients with refractory temporal epilepsy. "
],
"offsets": [
[
79,
212
]
]
},
{
"id": "3840",
"type": "abstract",
"text": [
"INTRODUCTION: In temporal lobe epilepsy (TLE), about 30% of the patients do not achieve adequate pharmacologic control of refractory crises, and surgery becomes an alternative. "
],
"offsets": [
[
213,
390
]
]
}
] | [
{
"id": "3841",
"type": "Diseases",
"text": [
"TLE"
],
"offsets": [
[
73,
76
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d80.s8.e0"
}
]
},
{
"id": "3842",
"type": "Species",
"text": [
"patients"
],
"offsets": [
[
31,
39
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d80.s8.e1"
}
]
},
{
"id": "3843",
"type": "Diseases",
"text": [
"refractory temporal epilepsy"
],
"offsets": [
[
182,
210
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d80.s9.e0"
}
]
},
{
"id": "3844",
"type": "Species",
"text": [
"patients"
],
"offsets": [
[
168,
176
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d80.s9.e1"
}
]
},
{
"id": "3845",
"type": "Diseases",
"text": [
"temporal lobe epilepsy"
],
"offsets": [
[
230,
252
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d80.s10.e0"
}
]
},
{
"id": "3846",
"type": "Diseases",
"text": [
"TLE"
],
"offsets": [
[
254,
257
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d80.s10.e1"
}
]
},
{
"id": "3847",
"type": "Species",
"text": [
"patients"
],
"offsets": [
[
277,
285
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d80.s10.e2"
}
]
}
] | [] | [] | [] |
3872 | miRNA-corp.d81 | [
{
"id": "3849",
"type": "title",
"text": [
"Yet, genetic testing for CADASIL is associated with a nameable proportion of false-negative results. "
],
"offsets": [
[
0,
101
]
]
},
{
"id": "3850",
"type": "abstract",
"text": [
"In 5 patients (4.0%), no mutation was identified. "
],
"offsets": [
[
102,
152
]
]
},
{
"id": "3851",
"type": "abstract",
"text": [
"RESULTS: We detected 54 distinct mutations (117 missense mutations and 3 in-frame deletions) in 120 (96.0%) of the 125 patients. "
],
"offsets": [
[
153,
282
]
]
},
{
"id": "3852",
"type": "abstract",
"text": [
"BACKGROUND: Mutations in the NOTCH3 gene are the cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), which is an important cause of stroke in young adults. "
],
"offsets": [
[
283,
498
]
]
},
{
"id": "3853",
"type": "abstract",
"text": [
"Spectrum of mutations in biopsy-proven CADASIL: implications for diagnostic strategies. "
],
"offsets": [
[
499,
588
]
]
},
{
"id": "3854",
"type": "abstract",
"text": [
"DESIGN: Screening for NOTCH3 mutations was performed in 125 unrelated German CADASIL patients with biopsy-proven disease by direct sequencing of exons coding for epidermal growth factor-like repeats. "
],
"offsets": [
[
589,
789
]
]
},
{
"id": "3855",
"type": "abstract",
"text": [
"OBJECTIVES: To identify the spectrum of NOTCH3 mutations in CADASIL and to discuss the implications for diagnostic strategies. "
],
"offsets": [
[
790,
917
]
]
},
{
"id": "3856",
"type": "abstract",
"text": [
"Mutations are typically located within epidermal growth factor-like repeat domains in the extracellular part of the Notch3 receptor. "
],
"offsets": [
[
918,
1051
]
]
}
] | [
{
"id": "3857",
"type": "Diseases",
"text": [
"CADASIL"
],
"offsets": [
[
25,
32
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d81.s0.e0"
}
]
},
{
"id": "3858",
"type": "Relation_Trigger",
"text": [
"associated"
],
"offsets": [
[
36,
46
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d81.s0.e1"
}
]
},
{
"id": "3859",
"type": "Species",
"text": [
"patients"
],
"offsets": [
[
107,
115
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d81.s5.e0"
}
]
},
{
"id": "3860",
"type": "Species",
"text": [
"patients"
],
"offsets": [
[
272,
280
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d81.s7.e0"
}
]
},
{
"id": "3861",
"type": "Diseases",
"text": [
"cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy"
],
"offsets": [
[
341,
431
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d81.s8.e0"
}
]
},
{
"id": "3862",
"type": "Diseases",
"text": [
"CADASIL"
],
"offsets": [
[
433,
440
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d81.s8.e1"
}
]
},
{
"id": "3863",
"type": "Diseases",
"text": [
"stroke"
],
"offsets": [
[
474,
480
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d81.s8.e2"
}
]
},
{
"id": "3864",
"type": "Genes/Proteins",
"text": [
"NOTCH3"
],
"offsets": [
[
312,
318
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d81.s8.e3"
}
]
},
{
"id": "3865",
"type": "Diseases",
"text": [
"CADASIL"
],
"offsets": [
[
538,
545
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d81.s9.e0"
}
]
},
{
"id": "3866",
"type": "Genes/Proteins",
"text": [
"NOTCH3"
],
"offsets": [
[
611,
617
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d81.s10.e0"
}
]
},
{
"id": "3867",
"type": "Diseases",
"text": [
"CADASIL"
],
"offsets": [
[
666,
673
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d81.s10.e1"
}
]
},
{
"id": "3868",
"type": "Species",
"text": [
"patients"
],
"offsets": [
[
674,
682
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d81.s10.e2"
}
]
},
{
"id": "3869",
"type": "Genes/Proteins",
"text": [
"NOTCH3"
],
"offsets": [
[
830,
836
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d81.s11.e0"
}
]
},
{
"id": "3870",
"type": "Diseases",
"text": [
"CADASIL"
],
"offsets": [
[
850,
857
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d81.s11.e1"
}
]
},
{
"id": "3871",
"type": "Genes/Proteins",
"text": [
"Notch3 receptor"
],
"offsets": [
[
1034,
1049
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d81.s13.e0"
}
]
}
] | [] | [] | [] |
3904 | miRNA-corp.d82 | [
{
"id": "3873",
"type": "title",
"text": [
"Mutations in ABHD12 cause the neurodegenerative disease PHARC: An inborn error of endocannabinoid metabolism. "
],
"offsets": [
[
0,
111
]
]
},
{
"id": "3874",
"type": "abstract",
"text": [
"Polyneuropathy, hearing loss, ataxia, retinitis pigmentosa, and cataract (PHARC) is a neurodegenerative disease marked by early-onset cataract and hearing loss, retinitis pigmentosa, and involvement of both the central and peripheral nervous systems, including demyelinating sensorimotor polyneuropathy and cerebellar ataxia. "
],
"offsets": [
[
112,
438
]
]
},
{
"id": "3875",
"type": "abstract",
"text": [
"Our findings show that ABHD12 performs essential functions in both the central and peripheral nervous systems and the eye. "
],
"offsets": [
[
439,
562
]
]
},
{
"id": "3876",
"type": "abstract",
"text": [
"Here we report that mutations in the ABHD12 gene cause PHARC disease and we describe the clinical manifestations in a total of 19 patients from four different countries. "
],
"offsets": [
[
563,
733
]
]
},
{
"id": "3877",
"type": "abstract",
"text": [
"The ABHD12 enzyme was recently shown to hydrolyze 2-arachidonoyl glycerol (2-AG), the main endocannabinoid lipid transmitter that acts on cannabinoid receptors CB1 and CB2. "
],
"offsets": [
[
734,
907
]
]
},
{
"id": "3878",
"type": "abstract",
"text": [
"The endocannabinoid system is involved in a wide range of physiological processes including neurotransmission, mood, appetite, pain appreciation, addiction behavior, and inflammation, and several potential drugs targeting these pathways are in development for clinical applications. "
],
"offsets": [
[
908,
1191
]
]
}
] | [
{
"id": "3879",
"type": "Genes/Proteins",
"text": [
"ABHD12"
],
"offsets": [
[
13,
19
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d82.s0.e0"
}
]
},
{
"id": "3880",
"type": "Diseases",
"text": [
"PHARC"
],
"offsets": [
[
56,
61
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d82.s0.e1"
}
]
},
{
"id": "3881",
"type": "Diseases",
"text": [
"neurodegenerative disease"
],
"offsets": [
[
30,
55
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d82.s0.e2"
}
]
},
{
"id": "3882",
"type": "Diseases",
"text": [
"Polyneuropathy"
],
"offsets": [
[
112,
126
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d82.s2.e0"
}
]
},
{
"id": "3883",
"type": "Diseases",
"text": [
"hearing loss"
],
"offsets": [
[
128,
140
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d82.s2.e1"
}
]
},
{
"id": "3884",
"type": "Diseases",
"text": [
"ataxia"
],
"offsets": [
[
142,
148
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d82.s2.e2"
}
]
},
{
"id": "3885",
"type": "Diseases",
"text": [
"retinitis pigmentosa"
],
"offsets": [
[
150,
170
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d82.s2.e3"
}
]
},
{
"id": "3886",
"type": "Diseases",
"text": [
"cataract"
],
"offsets": [
[
176,
184
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d82.s2.e4"
}
]
},
{
"id": "3887",
"type": "Diseases",
"text": [
"PHARC"
],
"offsets": [
[
186,
191
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d82.s2.e5"
}
]
},
{
"id": "3888",
"type": "Diseases",
"text": [
"cataract"
],
"offsets": [
[
246,
254
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d82.s2.e6"
}
]
},
{
"id": "3889",
"type": "Diseases",
"text": [
"cerebellar ataxia"
],
"offsets": [
[
419,
436
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d82.s2.e7"
}
]
},
{
"id": "3890",
"type": "Diseases",
"text": [
"hearing loss"
],
"offsets": [
[
259,
271
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d82.s2.e8"
}
]
},
{
"id": "3891",
"type": "Diseases",
"text": [
"retinitis pigmentosa"
],
"offsets": [
[
273,
293
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d82.s2.e9"
}
]
},
{
"id": "3892",
"type": "Diseases",
"text": [
"polyneuropathy"
],
"offsets": [
[
400,
414
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d82.s2.e10"
}
]
},
{
"id": "3893",
"type": "Diseases",
"text": [
"neurodegenerative disease"
],
"offsets": [
[
198,
223
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d82.s2.e11"
}
]
},
{
"id": "3894",
"type": "Genes/Proteins",
"text": [
"ABHD12"
],
"offsets": [
[
462,
468
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d82.s3.e0"
}
]
},
{
"id": "3895",
"type": "Genes/Proteins",
"text": [
"ABHD12"
],
"offsets": [
[
600,
606
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d82.s5.e0"
}
]
},
{
"id": "3896",
"type": "Diseases",
"text": [
"PHARC"
],
"offsets": [
[
618,
623
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d82.s5.e1"
}
]
},
{
"id": "3897",
"type": "Species",
"text": [
"patients"
],
"offsets": [
[
693,
701
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d82.s5.e2"
}
]
},
{
"id": "3898",
"type": "Genes/Proteins",
"text": [
"ABHD12"
],
"offsets": [
[
738,
744
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d82.s6.e0"
}
]
},
{
"id": "3899",
"type": "Genes/Proteins",
"text": [
"CB1"
],
"offsets": [
[
894,
897
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d82.s6.e1"
}
]
},
{
"id": "3900",
"type": "Genes/Proteins",
"text": [
"CB2"
],
"offsets": [
[
902,
905
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d82.s6.e2"
}
]
},
{
"id": "3901",
"type": "Relation_Trigger",
"text": [
"targeting"
],
"offsets": [
[
1120,
1129
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d82.s8.e0"
}
]
},
{
"id": "3902",
"type": "Diseases",
"text": [
"inflammation"
],
"offsets": [
[
1078,
1090
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d82.s8.e1"
}
]
},
{
"id": "3903",
"type": "Diseases",
"text": [
"pain"
],
"offsets": [
[
1035,
1039
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d82.s8.e2"
}
]
}
] | [] | [] | [] |
3962 | miRNA-corp.d83 | [
{
"id": "3905",
"type": "title",
"text": [
"HIV-1-infected opiate abusers often exhibit an accelerated form of HIV-1-associated dementia and enhanced neurological dysfunction. "
],
"offsets": [
[
0,
132
]
]
},
{
"id": "3906",
"type": "abstract",
"text": [
"Morphine treatment of human monocyte-derived macrophages induces differential miRNA and protein expression: impact on inflammation and oxidative stress in the central nervous system. "
],
"offsets": [
[
133,
317
]
]
},
{
"id": "3907",
"type": "abstract",
"text": [
"In order to understand the role of morphine in this process, we performed a genome-wide association study at the micro RNA (miRNA) and protein levels in human monocyte-derived macrophages (h-mdms). "
],
"offsets": [
[
318,
516
]
]
},
{
"id": "3908",
"type": "abstract",
"text": [
"Productive HIV-1 infection of microglia and perivascular macrophages and the resultant secretion of neurotoxic molecules by these cells contribute to this phenomenon. "
],
"offsets": [
[
517,
684
]
]
},
{
"id": "3909",
"type": "abstract",
"text": [
"Computational analysis predicted fibroblast growth factor-2 (FGF-2) as the strongest target gene for hsa-miR15b. "
],
"offsets": [
[
685,
798
]
]
},
{
"id": "3910",
"type": "abstract",
"text": [
"A total of 26 differentially expressed miRNA were identified (P < 0.01), of which hsa-miR-15b and hsa-miR-181b had the greatest increase and decrease in expression levels, respectively. "
],
"offsets": [
[
799,
985
]
]
},
{
"id": "3911",
"type": "abstract",
"text": [
"Both hsa-miR-15b and hsa-miR-181b have several predicted gene targets involved in inflammation and T-cell activation pathways. "
],
"offsets": [
[
986,
1113
]
]
},
{
"id": "3912",
"type": "abstract",
"text": [
"Of note, we observed a decrease in FGF-2 protein expression in response to morphine. "
],
"offsets": [
[
1114,
1199
]
]
},
{
"id": "3913",
"type": "abstract",
"text": [
"In this context, we observed induction of MCP-2 and IL-6 by morphine. "
],
"offsets": [
[
1200,
1270
]
]
},
{
"id": "3914",
"type": "abstract",
"text": [
"Of note, differentially expressed miRNAs (hsa-miR-15b and 181-b) may have a potential role in regulating these processes. "
],
"offsets": [
[
1271,
1395
]
]
},
{
"id": "3915",
"type": "abstract",
"text": [
"Collectively, these observations demonstrate that morphine induces inflammation and oxidative stress in h-mdms thereby contributing to expansion of HIV-1 CNS reservoir expansion and disease progression. "
],
"offsets": [
[
1396,
1599
]
]
},
{
"id": "3916",
"type": "abstract",
"text": [
"HIV-1 infection did not induce mitochondrial superoxide dismutase. "
],
"offsets": [
[
1600,
1667
]
]
}
] | [
{
"id": "3917",
"type": "Diseases",
"text": [
"dementia"
],
"offsets": [
[
84,
92
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d83.s0.e0"
}
]
},
{
"id": "3918",
"type": "Species",
"text": [
"HIV-1"
],
"offsets": [
[
67,
72
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d83.s0.e1"
}
]
},
{
"id": "3919",
"type": "Species",
"text": [
"HIV-1"
],
"offsets": [
[
0,
5
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d83.s0.e2"
}
]
},
{
"id": "3920",
"type": "Diseases",
"text": [
"neurological dysfunction"
],
"offsets": [
[
106,
130
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d83.s0.e3"
}
]
},
{
"id": "3921",
"type": "Non-Specific_miRNAs",
"text": [
"miRNA"
],
"offsets": [
[
211,
216
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d83.s1.e0"
}
]
},
{
"id": "3922",
"type": "Diseases",
"text": [
"inflammation"
],
"offsets": [
[
251,
263
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d83.s1.e1"
}
]
},
{
"id": "3923",
"type": "Species",
"text": [
"human"
],
"offsets": [
[
155,
160
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d83.s1.e2"
}
]
},
{
"id": "3924",
"type": "Non-Specific_miRNAs",
"text": [
"micro RNA"
],
"offsets": [
[
431,
440
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d83.s2.e0"
}
]
},
{
"id": "3925",
"type": "Non-Specific_miRNAs",
"text": [
"miRNA"
],
"offsets": [
[
442,
447
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d83.s2.e1"
}
]
},
{
"id": "3926",
"type": "Species",
"text": [
"human"
],
"offsets": [
[
471,
476
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d83.s2.e2"
}
]
},
{
"id": "3927",
"type": "Species",
"text": [
"HIV-1"
],
"offsets": [
[
528,
533
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d83.s3.e0"
}
]
},
{
"id": "3928",
"type": "Diseases",
"text": [
"HIV-1 infection"
],
"offsets": [
[
528,
543
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d83.s3.e1"
}
]
},
{
"id": "3929",
"type": "Genes/Proteins",
"text": [
"fibroblast growth factor-2"
],
"offsets": [
[
718,
744
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d83.s4.e0"
}
]
},
{
"id": "3930",
"type": "Genes/Proteins",
"text": [
"FGF-2"
],
"offsets": [
[
746,
751
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d83.s4.e1"
}
]
},
{
"id": "3931",
"type": "Specific_miRNAs",
"text": [
"hsa-miR15b"
],
"offsets": [
[
786,
796
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d83.s4.e2"
}
]
},
{
"id": "3932",
"type": "Relation_Trigger",
"text": [
"target"
],
"offsets": [
[
770,
776
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d83.s4.e3"
}
]
},
{
"id": "3933",
"type": "Specific_miRNAs",
"text": [
"hsa-miR-15b"
],
"offsets": [
[
881,
892
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d83.s5.e0"
}
]
},
{
"id": "3934",
"type": "Specific_miRNAs",
"text": [
"hsa-miR-181b"
],
"offsets": [
[
897,
909
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d83.s5.e1"
}
]
},
{
"id": "3935",
"type": "Non-Specific_miRNAs",
"text": [
"miRNA"
],
"offsets": [
[
838,
843
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d83.s5.e2"
}
]
},
{
"id": "3936",
"type": "Relation_Trigger",
"text": [
"differentially expressed"
],
"offsets": [
[
813,
837
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d83.s5.e3"
}
]
},
{
"id": "3937",
"type": "Relation_Trigger",
"text": [
"increase and decrease in expression levels"
],
"offsets": [
[
927,
969
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d83.s5.e4"
}
]
},
{
"id": "3938",
"type": "Relation_Trigger",
"text": [
"decrease in expression levels"
],
"offsets": [
[
940,
969
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d83.s5.e5"
}
]
},
{
"id": "3939",
"type": "Relation_Trigger",
"text": [
"decrease in expression levels"
],
"offsets": [
[
940,
969
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d83.s5.e6"
}
]
},
{
"id": "3940",
"type": "Specific_miRNAs",
"text": [
"hsa-miR-15b"
],
"offsets": [
[
991,
1002
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d83.s6.e0"
}
]
},
{
"id": "3941",
"type": "Specific_miRNAs",
"text": [
"hsa-miR-181b"
],
"offsets": [
[
1007,
1019
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d83.s6.e1"
}
]
},
{
"id": "3942",
"type": "Relation_Trigger",
"text": [
"predicted gene targets"
],
"offsets": [
[
1033,
1055
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d83.s6.e2"
}
]
},
{
"id": "3943",
"type": "Relation_Trigger",
"text": [
"activation"
],
"offsets": [
[
1092,
1102
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d83.s6.e3"
}
]
},
{
"id": "3944",
"type": "Diseases",
"text": [
"inflammation"
],
"offsets": [
[
1068,
1080
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d83.s6.e4"
}
]
},
{
"id": "3945",
"type": "Genes/Proteins",
"text": [
"FGF-2"
],
"offsets": [
[
1149,
1154
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d83.s7.e0"
}
]
},
{
"id": "3946",
"type": "Relation_Trigger",
"text": [
"decrease in FGF-2 protein expression"
],
"offsets": [
[
1137,
1173
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d83.s7.e1"
}
]
},
{
"id": "3947",
"type": "Genes/Proteins",
"text": [
"MCP-2"
],
"offsets": [
[
1242,
1247
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d83.s9.e0"
}
]
},
{
"id": "3948",
"type": "Genes/Proteins",
"text": [
"IL-6"
],
"offsets": [
[
1252,
1256
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d83.s9.e1"
}
]
},
{
"id": "3949",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
[
1305,
1311
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d83.s10.e0"
}
]
},
{
"id": "3950",
"type": "Relation_Trigger",
"text": [
"differentially expressed"
],
"offsets": [
[
1280,
1304
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d83.s10.e1"
}
]
},
{
"id": "3951",
"type": "Relation_Trigger",
"text": [
"regulating"
],
"offsets": [
[
1365,
1375
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d83.s10.e2"
}
]
},
{
"id": "3952",
"type": "Specific_miRNAs",
"text": [
"hsa-miR-15b and 181-b"
],
"offsets": [
[
1313,
1334
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d83.s10.e3"
}
]
},
{
"id": "3953",
"type": "Species",
"text": [
"HIV-1"
],
"offsets": [
[
1544,
1549
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d83.s11.e0"
}
]
},
{
"id": "3954",
"type": "Diseases",
"text": [
"inflammation"
],
"offsets": [
[
1463,
1475
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d83.s11.e1"
}
]
},
{
"id": "3955",
"type": "Species",
"text": [
"HIV-1"
],
"offsets": [
[
1600,
1605
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d83.s12.e0"
}
]
},
{
"id": "3956",
"type": "Diseases",
"text": [
"HIV-1 infection"
],
"offsets": [
[
1600,
1615
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d83.s12.e1"
}
]
}
] | [] | [] | [
{
"id": "3957",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d83.s1.e0",
"arg2_id": "miRNA-corp.d83.s1.e1",
"normalized": []
},
{
"id": "3958",
"type": "Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d83.s4.e2",
"arg2_id": "miRNA-corp.d83.s4.e0",
"normalized": []
},
{
"id": "3959",
"type": "Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d83.s4.e2",
"arg2_id": "miRNA-corp.d83.s4.e1",
"normalized": []
},
{
"id": "3960",
"type": "Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d83.s6.e0",
"arg2_id": "miRNA-corp.d83.s6.e4",
"normalized": []
},
{
"id": "3961",
"type": "Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d83.s6.e1",
"arg2_id": "miRNA-corp.d83.s6.e4",
"normalized": []
}
] |
4003 | miRNA-corp.d84 | [
{
"id": "3963",
"type": "title",
"text": [
"MRI scan showed an area of encephalomalacia in the left temporal lobe, as well as post-surgical changes in the left frontal area. "
],
"offsets": [
[
0,
130
]
]
},
{
"id": "3964",
"type": "abstract",
"text": [
"He presented with status epilepticus every two or three months, and required long periods of hospitalization on each occasion for post-ictal confusion and aphasia. "
],
"offsets": [
[
131,
295
]
]
},
{
"id": "3965",
"type": "abstract",
"text": [
"He continued to have frequent seizures despite treatment with multiple combinations of antiepileptic medications. "
],
"offsets": [
[
296,
410
]
]
},
{
"id": "3966",
"type": "abstract",
"text": [
"EEG telemetry recorded multiple seizures, all with a clear focus in the left temporal area. "
],
"offsets": [
[
411,
503
]
]
},
{
"id": "3967",
"type": "abstract",
"text": [
"CASE REPORT: We report a case of a 75-year-old right-handed man who underwent a left fronto-temporal craniotomy for resection of a suprasellar meningioma in 2002. "
],
"offsets": [
[
504,
667
]
]
},
{
"id": "3968",
"type": "abstract",
"text": [
"Immediately following hospital discharge, he began to experience complex partial seizures. "
],
"offsets": [
[
668,
759
]
]
},
{
"id": "3969",
"type": "abstract",
"text": [
"BACKGROUND: Epilepsy surgery is increasingly well-supported as an effective treatment for patients with intractable epilepsy. "
],
"offsets": [
[
760,
886
]
]
},
{
"id": "3970",
"type": "abstract",
"text": [
"It is most often performed on younger patients and the safety and efficacy of epilepsy surgery in elderly patients are not frequently described. "
],
"offsets": [
[
887,
1032
]
]
},
{
"id": "3971",
"type": "abstract",
"text": [
"Epilepsy surgery in the elderly: an unusual case of a 75-year-old man with recurrent status epilepticus. "
],
"offsets": [
[
1033,
1139
]
]
},
{
"id": "3972",
"type": "abstract",
"text": [
"In addition, few cases with such a malignant evolution of temporal lobe epilepsy have been described in this age group. "
],
"offsets": [
[
1140,
1262
]
]
},
{
"id": "3973",
"type": "abstract",
"text": [
"Neuropsychological testing showed bilateral memory impairment with no significant cognitive decline expected after unilateral temporal lobe resection. "
],
"offsets": [
[
1263,
1414
]
]
},
{
"id": "3974",
"type": "abstract",
"text": [
"CONCLUSIONS: This is one of the oldest patients reported in the literature with epilepsy surgery and supports the possibility of epilepsy surgery in elderly patients for particular cases. "
],
"offsets": [
[
1415,
1603
]
]
},
{
"id": "3975",
"type": "abstract",
"text": [
"Since surgery, the patient was not seizure-free (Engel class II-b), but had no further episodes of status epilepticus in one year and two months of follow-up. "
],
"offsets": [
[
1604,
1763
]
]
}
] | [
{
"id": "3976",
"type": "Diseases",
"text": [
"encephalomalacia"
],
"offsets": [
[
27,
43
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d84.s0.e0"
}
]
},
{
"id": "3977",
"type": "Diseases",
"text": [
"status epilepticus"
],
"offsets": [
[
149,
167
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d84.s1.e0"
}
]
},
{
"id": "3978",
"type": "Diseases",
"text": [
"aphasia"
],
"offsets": [
[
286,
293
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d84.s1.e1"
}
]
},
{
"id": "3979",
"type": "Diseases",
"text": [
"post-ictal confusion"
],
"offsets": [
[
261,
281
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d84.s1.e2"
}
]
},
{
"id": "3980",
"type": "Diseases",
"text": [
"seizures"
],
"offsets": [
[
326,
334
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d84.s2.e0"
}
]
},
{
"id": "3981",
"type": "Diseases",
"text": [
"multiple seizures"
],
"offsets": [
[
434,
451
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d84.s3.e0"
}
]
},
{
"id": "3982",
"type": "Diseases",
"text": [
"suprasellar meningioma"
],
"offsets": [
[
635,
657
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d84.s5.e0"
}
]
},
{
"id": "3983",
"type": "Species",
"text": [
"man"
],
"offsets": [
[
564,
567
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d84.s5.e1"
}
]
},
{
"id": "3984",
"type": "Diseases",
"text": [
"seizures"
],
"offsets": [
[
749,
757
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d84.s6.e0"
}
]
},
{
"id": "3985",
"type": "Diseases",
"text": [
"Epilepsy"
],
"offsets": [
[
772,
780
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d84.s7.e0"
}
]
},
{
"id": "3986",
"type": "Diseases",
"text": [
"epilepsy"
],
"offsets": [
[
876,
884
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d84.s7.e1"
}
]
},
{
"id": "3987",
"type": "Species",
"text": [
"patients"
],
"offsets": [
[
850,
858
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d84.s7.e2"
}
]
},
{
"id": "3988",
"type": "Diseases",
"text": [
"epilepsy"
],
"offsets": [
[
965,
973
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d84.s8.e0"
}
]
},
{
"id": "3989",
"type": "Species",
"text": [
"patients"
],
"offsets": [
[
925,
933
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d84.s8.e1"
}
]
},
{
"id": "3990",
"type": "Species",
"text": [
"patients"
],
"offsets": [
[
993,
1001
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d84.s8.e2"
}
]
},
{
"id": "3991",
"type": "Diseases",
"text": [
"status epilepticus"
],
"offsets": [
[
1118,
1136
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d84.s9.e0"
}
]
},
{
"id": "3992",
"type": "Diseases",
"text": [
"Epilepsy"
],
"offsets": [
[
1033,
1041
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d84.s9.e1"
}
]
},
{
"id": "3993",
"type": "Species",
"text": [
"man"
],
"offsets": [
[
1099,
1102
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d84.s9.e2"
}
]
},
{
"id": "3994",
"type": "Diseases",
"text": [
"temporal lobe epilepsy"
],
"offsets": [
[
1198,
1220
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d84.s10.e0"
}
]
},
{
"id": "3995",
"type": "Diseases",
"text": [
"bilateral memory impairment"
],
"offsets": [
[
1297,
1324
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d84.s12.e0"
}
]
},
{
"id": "3996",
"type": "Diseases",
"text": [
"epilepsy"
],
"offsets": [
[
1495,
1503
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d84.s13.e0"
}
]
},
{
"id": "3997",
"type": "Diseases",
"text": [
"epilepsy"
],
"offsets": [
[
1544,
1552
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d84.s13.e1"
}
]
},
{
"id": "3998",
"type": "Species",
"text": [
"patients"
],
"offsets": [
[
1454,
1462
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d84.s13.e2"
}
]
},
{
"id": "3999",
"type": "Species",
"text": [
"patients"
],
"offsets": [
[
1572,
1580
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d84.s13.e3"
}
]
},
{
"id": "4000",
"type": "Diseases",
"text": [
"seizure"
],
"offsets": [
[
1639,
1646
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d84.s14.e0"
}
]
},
{
"id": "4001",
"type": "Diseases",
"text": [
"status epilepticus"
],
"offsets": [
[
1703,
1721
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d84.s14.e1"
}
]
},
{
"id": "4002",
"type": "Species",
"text": [
"patient"
],
"offsets": [
[
1623,
1630
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d84.s14.e2"
}
]
}
] | [] | [] | [] |
4037 | miRNA-corp.d85 | [
{
"id": "4004",
"type": "title",
"text": [
"Aberrant expression of miRNAs can lead to diseases, including cancer. "
],
"offsets": [
[
0,
70
]
]
},
{
"id": "4005",
"type": "abstract",
"text": [
"Expression of many miRNAs in the de-differentiated brain tumor cancer stem cells resembles that of neural stem cells. "
],
"offsets": [
[
71,
189
]
]
},
{
"id": "4006",
"type": "abstract",
"text": [
"MicroRNAs: regulators of oncogenesis and stemness. "
],
"offsets": [
[
190,
242
]
]
},
{
"id": "4007",
"type": "abstract",
"text": [
"MicroRNAs (miRNAs) are essential post-transcriptional regulators that determine cell identity and fate. "
],
"offsets": [
[
243,
347
]
]
},
{
"id": "4008",
"type": "abstract",
"text": [
"In this issue of BMC Medicine, Silber et al provide evidence of the expression of such miRNAs and their potential to mediate differentiation in both stem cell populations. "
],
"offsets": [
[
348,
520
]
]
},
{
"id": "4009",
"type": "abstract",
"text": [
"In this commentary, we discuss the known functions of miRNAs in cancer and stem cells, their therapeutic potential and how the findings of Silber et al provide insight into the role of miR-124/miR-137 dysregulation in glioblastomas. "
],
"offsets": [
[
521,
756
]
]
}
] | [
{
"id": "4010",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
[
23,
29
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d85.s0.e0"
}
]
},
{
"id": "4011",
"type": "Relation_Trigger",
"text": [
"Aberrant expression"
],
"offsets": [
[
0,
19
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d85.s0.e1"
}
]
},
{
"id": "4012",
"type": "Diseases",
"text": [
"cancer"
],
"offsets": [
[
62,
68
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d85.s0.e2"
}
]
},
{
"id": "4013",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
[
90,
96
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d85.s1.e0"
}
]
},
{
"id": "4014",
"type": "Diseases",
"text": [
"de-differentiated brain tumor"
],
"offsets": [
[
104,
133
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d85.s1.e1"
}
]
},
{
"id": "4015",
"type": "Diseases",
"text": [
"cancer"
],
"offsets": [
[
134,
140
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d85.s1.e2"
}
]
},
{
"id": "4016",
"type": "Non-Specific_miRNAs",
"text": [
"MicroRNAs"
],
"offsets": [
[
190,
199
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d85.s2.e0"
}
]
},
{
"id": "4017",
"type": "Relation_Trigger",
"text": [
"regulators"
],
"offsets": [
[
201,
211
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d85.s2.e1"
}
]
},
{
"id": "4018",
"type": "Non-Specific_miRNAs",
"text": [
"MicroRNAs"
],
"offsets": [
[
243,
252
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d85.s3.e0"
}
]
},
{
"id": "4019",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
[
254,
260
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d85.s3.e1"
}
]
},
{
"id": "4020",
"type": "Relation_Trigger",
"text": [
"regulators"
],
"offsets": [
[
297,
307
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d85.s3.e2"
}
]
},
{
"id": "4021",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
[
435,
441
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d85.s4.e0"
}
]
},
{
"id": "4022",
"type": "Specific_miRNAs",
"text": [
"miR-124"
],
"offsets": [
[
706,
713
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d85.s5.e0"
}
]
},
{
"id": "4023",
"type": "Specific_miRNAs",
"text": [
"miR-137"
],
"offsets": [
[
714,
721
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d85.s5.e1"
}
]
},
{
"id": "4024",
"type": "Diseases",
"text": [
"glioblastomas"
],
"offsets": [
[
739,
752
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d85.s5.e2"
}
]
},
{
"id": "4025",
"type": "Relation_Trigger",
"text": [
"dysregulation"
],
"offsets": [
[
722,
735
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d85.s5.e3"
}
]
},
{
"id": "4026",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
[
575,
581
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d85.s5.e4"
}
]
},
{
"id": "4027",
"type": "Diseases",
"text": [
"cancer"
],
"offsets": [
[
585,
591
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d85.s5.e5"
}
]
}
] | [] | [] | [
{
"id": "4028",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d85.s0.e0",
"arg2_id": "miRNA-corp.d85.s0.e2",
"normalized": []
},
{
"id": "4029",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d85.s1.e0",
"arg2_id": "miRNA-corp.d85.s1.e1",
"normalized": []
},
{
"id": "4030",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d85.s1.e0",
"arg2_id": "miRNA-corp.d85.s1.e2",
"normalized": []
},
{
"id": "4031",
"type": "Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d85.s5.e0",
"arg2_id": "miRNA-corp.d85.s5.e5",
"normalized": []
},
{
"id": "4032",
"type": "Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d85.s5.e0",
"arg2_id": "miRNA-corp.d85.s5.e2",
"normalized": []
},
{
"id": "4033",
"type": "Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d85.s5.e1",
"arg2_id": "miRNA-corp.d85.s5.e5",
"normalized": []
},
{
"id": "4034",
"type": "Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d85.s5.e1",
"arg2_id": "miRNA-corp.d85.s5.e2",
"normalized": []
},
{
"id": "4035",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d85.s5.e4",
"arg2_id": "miRNA-corp.d85.s5.e5",
"normalized": []
},
{
"id": "4036",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d85.s5.e4",
"arg2_id": "miRNA-corp.d85.s5.e2",
"normalized": []
}
] |
4088 | miRNA-corp.d86 | [
{
"id": "4038",
"type": "title",
"text": [
"RESULTS: We hypothesized that schizophrenia might be associated with altered miRNA profiles. "
],
"offsets": [
[
0,
93
]
]
},
{
"id": "4039",
"type": "abstract",
"text": [
"To investigate this possibility we compared the expression of 264 human miRNAs from postmortem prefrontal cortex tissue of individuals with schizophrenia (n = 13) or schizoaffective disorder (n = 2) to tissue of 21 psychiatrically unaffected individuals using a custom miRNA microarray. "
],
"offsets": [
[
94,
381
]
]
},
{
"id": "4040",
"type": "abstract",
"text": [
"Allowing a 5% false discovery rate, we found that 16 miRNAs were differentially expressed in prefrontal cortex of patient subjects, with 15 expressed at lower levels (fold change 0.63 to 0.89) and 1 at a higher level (fold change 1.77) than in the psychiatrically unaffected comparison subjects. "
],
"offsets": [
[
382,
678
]
]
},
{
"id": "4041",
"type": "abstract",
"text": [
"The expression levels of 12 selected miRNAs were also determined by quantitative RT-PCR in our lab. "
],
"offsets": [
[
679,
779
]
]
},
{
"id": "4042",
"type": "abstract",
"text": [
"For the eight miRNAs distinguished by being expressed at lower microarray levels in schizophrenia samples versus comparison samples, seven were also expressed at lower levels with quantitative RT-PCR. "
],
"offsets": [
[
780,
981
]
]
},
{
"id": "4043",
"type": "abstract",
"text": [
"CONCLUSION: This study is the first to find altered miRNA profiles in postmortem prefrontal cortex from schizophrenia patients. "
],
"offsets": [
[
982,
1112
]
]
},
{
"id": "4044",
"type": "abstract",
"text": [
"microRNA expression in the prefrontal cortex of individuals with schizophrenia and schizoaffective disorder. "
],
"offsets": [
[
1113,
1223
]
]
},
{
"id": "4045",
"type": "abstract",
"text": [
"BACKGROUND: microRNAs (miRNAs) are small, noncoding RNA molecules that are now thought to regulate the expression of many mRNAs. "
],
"offsets": [
[
1224,
1353
]
]
},
{
"id": "4046",
"type": "abstract",
"text": [
"They have been implicated in the etiology of a variety of complex diseases, including Tourette's syndrome, Fragile x syndrome, and several types of cancer. "
],
"offsets": [
[
1354,
1510
]
]
}
] | [
{
"id": "4047",
"type": "Non-Specific_miRNAs",
"text": [
"miRNA"
],
"offsets": [
[
77,
82
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d86.s0.e0"
}
]
},
{
"id": "4048",
"type": "Relation_Trigger",
"text": [
"associated"
],
"offsets": [
[
53,
63
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d86.s0.e1"
}
]
},
{
"id": "4049",
"type": "Relation_Trigger",
"text": [
"altered miRNA profiles"
],
"offsets": [
[
69,
91
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d86.s0.e2"
}
]
},
{
"id": "4050",
"type": "Diseases",
"text": [
"schizophrenia"
],
"offsets": [
[
30,
43
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d86.s0.e3"
}
]
},
{
"id": "4051",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
[
166,
172
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d86.s1.e0"
}
]
},
{
"id": "4052",
"type": "Non-Specific_miRNAs",
"text": [
"miRNA"
],
"offsets": [
[
363,
368
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d86.s1.e1"
}
]
},
{
"id": "4053",
"type": "Diseases",
"text": [
"schizoaffective disorder"
],
"offsets": [
[
260,
284
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d86.s1.e2"
}
]
},
{
"id": "4054",
"type": "Diseases",
"text": [
"schizophrenia"
],
"offsets": [
[
234,
247
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d86.s1.e3"
}
]
},
{
"id": "4055",
"type": "Species",
"text": [
"human"
],
"offsets": [
[
160,
165
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d86.s1.e4"
}
]
},
{
"id": "4056",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
[
435,
441
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d86.s2.e0"
}
]
},
{
"id": "4057",
"type": "Relation_Trigger",
"text": [
"differentially expressed"
],
"offsets": [
[
447,
471
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d86.s2.e1"
}
]
},
{
"id": "4058",
"type": "Relation_Trigger",
"text": [
"higher level"
],
"offsets": [
[
586,
598
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d86.s2.e2"
}
]
},
{
"id": "4059",
"type": "Relation_Trigger",
"text": [
"expressed at lower levels"
],
"offsets": [
[
522,
547
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d86.s2.e3"
}
]
},
{
"id": "4060",
"type": "Species",
"text": [
"patient"
],
"offsets": [
[
496,
503
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d86.s2.e4"
}
]
},
{
"id": "4061",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
[
716,
722
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d86.s3.e0"
}
]
},
{
"id": "4062",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
[
794,
800
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d86.s4.e0"
}
]
},
{
"id": "4063",
"type": "Relation_Trigger",
"text": [
"expressed at lower levels"
],
"offsets": [
[
929,
954
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d86.s4.e1"
}
]
},
{
"id": "4064",
"type": "Diseases",
"text": [
"schizophrenia"
],
"offsets": [
[
864,
877
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d86.s4.e2"
}
]
},
{
"id": "4065",
"type": "Relation_Trigger",
"text": [
"expressed at lower microarray levels"
],
"offsets": [
[
824,
860
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d86.s4.e3"
}
]
},
{
"id": "4066",
"type": "Non-Specific_miRNAs",
"text": [
"miRNA"
],
"offsets": [
[
1034,
1039
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d86.s5.e0"
}
]
},
{
"id": "4067",
"type": "Diseases",
"text": [
"schizophrenia"
],
"offsets": [
[
1086,
1099
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d86.s5.e1"
}
]
},
{
"id": "4068",
"type": "Relation_Trigger",
"text": [
"altered miRNA profiles"
],
"offsets": [
[
1026,
1048
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d86.s5.e2"
}
]
},
{
"id": "4069",
"type": "Species",
"text": [
"patients"
],
"offsets": [
[
1100,
1108
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d86.s5.e3"
}
]
},
{
"id": "4070",
"type": "Non-Specific_miRNAs",
"text": [
"microRNA"
],
"offsets": [
[
1113,
1121
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d86.s6.e0"
}
]
},
{
"id": "4071",
"type": "Diseases",
"text": [
"schizophrenia"
],
"offsets": [
[
1178,
1191
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d86.s6.e1"
}
]
},
{
"id": "4072",
"type": "Diseases",
"text": [
"schizoaffective disorder"
],
"offsets": [
[
1196,
1220
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d86.s6.e2"
}
]
},
{
"id": "4073",
"type": "Non-Specific_miRNAs",
"text": [
"microRNAs"
],
"offsets": [
[
1236,
1245
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d86.s7.e0"
}
]
},
{
"id": "4074",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
[
1247,
1253
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d86.s7.e1"
}
]
},
{
"id": "4075",
"type": "Relation_Trigger",
"text": [
"regulate the expression"
],
"offsets": [
[
1314,
1337
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d86.s7.e2"
}
]
},
{
"id": "4076",
"type": "Diseases",
"text": [
"Tourette's syndrome"
],
"offsets": [
[
1440,
1459
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d86.s8.e0"
}
]
},
{
"id": "4077",
"type": "Diseases",
"text": [
"Fragile x syndrome"
],
"offsets": [
[
1461,
1479
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d86.s8.e1"
}
]
},
{
"id": "4078",
"type": "Diseases",
"text": [
"cancer"
],
"offsets": [
[
1502,
1508
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d86.s8.e2"
}
]
}
] | [] | [] | [
{
"id": "4079",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d86.s0.e0",
"arg2_id": "miRNA-corp.d86.s0.e3",
"normalized": []
},
{
"id": "4080",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d86.s1.e0",
"arg2_id": "miRNA-corp.d86.s1.e2",
"normalized": []
},
{
"id": "4081",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d86.s1.e0",
"arg2_id": "miRNA-corp.d86.s1.e3",
"normalized": []
},
{
"id": "4082",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d86.s1.e1",
"arg2_id": "miRNA-corp.d86.s1.e2",
"normalized": []
},
{
"id": "4083",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d86.s1.e1",
"arg2_id": "miRNA-corp.d86.s1.e3",
"normalized": []
},
{
"id": "4084",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d86.s4.e0",
"arg2_id": "miRNA-corp.d86.s4.e2",
"normalized": []
},
{
"id": "4085",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d86.s5.e0",
"arg2_id": "miRNA-corp.d86.s5.e1",
"normalized": []
},
{
"id": "4086",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d86.s6.e0",
"arg2_id": "miRNA-corp.d86.s6.e1",
"normalized": []
},
{
"id": "4087",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d86.s6.e0",
"arg2_id": "miRNA-corp.d86.s6.e2",
"normalized": []
}
] |
4101 | miRNA-corp.d87 | [
{
"id": "4089",
"type": "title",
"text": [
"We explored to what extent abnormalities of echogenicity of the periventricular crossroads correlate with changes in size of the corpus callosum. "
],
"offsets": [
[
0,
146
]
]
},
{
"id": "4090",
"type": "abstract",
"text": [
"Our study included nine infants (gestation from 26-41 weeks; birth weight between 938-4450 grams) with perinatal brain injury. "
],
"offsets": [
[
147,
274
]
]
},
{
"id": "4091",
"type": "abstract",
"text": [
"We found a statistically significant correlation between the increased echogenicity in the crossroad areas and the decrease of the corpus callosum midsagittal area (p < 0.05). "
],
"offsets": [
[
275,
451
]
]
},
{
"id": "4092",
"type": "abstract",
"text": [
"Changes of the corpus callosum in children who suffered perinatal injury of the periventricular crossroads of pathways. "
],
"offsets": [
[
452,
573
]
]
},
{
"id": "4093",
"type": "abstract",
"text": [
"There is a high incidence of periventricular leukomalacia, caused by hypoxia-ischemia, in preterm infants. "
],
"offsets": [
[
574,
681
]
]
}
] | [
{
"id": "4094",
"type": "Relation_Trigger",
"text": [
"correlate"
],
"offsets": [
[
91,
100
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d87.s0.e0"
}
]
},
{
"id": "4095",
"type": "Diseases",
"text": [
"perinatal brain injury"
],
"offsets": [
[
250,
272
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d87.s3.e0"
}
]
},
{
"id": "4096",
"type": "Relation_Trigger",
"text": [
"correlation"
],
"offsets": [
[
312,
323
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d87.s4.e0"
}
]
},
{
"id": "4097",
"type": "Species",
"text": [
"children"
],
"offsets": [
[
486,
494
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d87.s7.e0"
}
]
},
{
"id": "4098",
"type": "Diseases",
"text": [
"perinatal injury"
],
"offsets": [
[
508,
524
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d87.s7.e1"
}
]
},
{
"id": "4099",
"type": "Diseases",
"text": [
"periventricular leukomalacia"
],
"offsets": [
[
603,
631
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d87.s8.e0"
}
]
},
{
"id": "4100",
"type": "Diseases",
"text": [
"hypoxia-ischemia"
],
"offsets": [
[
643,
659
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d87.s8.e1"
}
]
}
] | [] | [] | [] |
4122 | miRNA-corp.d88 | [
{
"id": "4102",
"type": "title",
"text": [
"These results confirm those of other studies with animals and humans using novel imaging techniques, suggesting that the motor homunculus may not always be considered a definite and absolute representation of M1. "
],
"offsets": [
[
0,
215
]
]
},
{
"id": "4103",
"type": "abstract",
"text": [
"The results of this study challenge the notion of orderly topographic relationships between the human sensorimotor functions and their representation in the primary motor cortex. "
],
"offsets": [
[
216,
395
]
]
},
{
"id": "4104",
"type": "abstract",
"text": [
"A total of 43 maps from 36 patients were analyzed. "
],
"offsets": [
[
396,
447
]
]
},
{
"id": "4105",
"type": "abstract",
"text": [
"The authors found variations in the organization of M1 (primary motor cortex) in seven patients (19.4%). "
],
"offsets": [
[
448,
553
]
]
},
{
"id": "4106",
"type": "abstract",
"text": [
"Four patients (11.1%) presented mosaicism (overlapping of functional areas), two (5.6%) presented variability (inverted disposition of M1 functional areas), and one (2.8%) had both. "
],
"offsets": [
[
554,
736
]
]
},
{
"id": "4107",
"type": "abstract",
"text": [
"Functional variability of the human cortical motor map: electrical stimulation findings in perirolandic epilepsy surgery. "
],
"offsets": [
[
737,
860
]
]
},
{
"id": "4108",
"type": "abstract",
"text": [
"The purpose of this study was to assess the cortical representation of sensorimotor functions in patients undergoing perirolandic epilepsy surgery, focusing on somatotopy, mosaicism, and variability of function in relation to the classic motor homunculus. "
],
"offsets": [
[
861,
1117
]
]
},
{
"id": "4109",
"type": "abstract",
"text": [
"The authors studied 36 patients in whom intraoperative or extraoperative electrical cortical stimulation to map motor functions was performed. "
],
"offsets": [
[
1118,
1261
]
]
}
] | [
{
"id": "4110",
"type": "Species",
"text": [
"humans"
],
"offsets": [
[
62,
68
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d88.s0.e0"
}
]
},
{
"id": "4111",
"type": "Species",
"text": [
"human"
],
"offsets": [
[
312,
317
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d88.s1.e0"
}
]
},
{
"id": "4112",
"type": "Species",
"text": [
"patients"
],
"offsets": [
[
423,
431
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d88.s3.e0"
}
]
},
{
"id": "4113",
"type": "Species",
"text": [
"patients"
],
"offsets": [
[
535,
543
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d88.s4.e0"
}
]
},
{
"id": "4114",
"type": "Diseases",
"text": [
"mosaicism"
],
"offsets": [
[
586,
595
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d88.s5.e0"
}
]
},
{
"id": "4115",
"type": "Species",
"text": [
"patients"
],
"offsets": [
[
559,
567
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d88.s5.e1"
}
]
},
{
"id": "4116",
"type": "Diseases",
"text": [
"perirolandic epilepsy"
],
"offsets": [
[
828,
849
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d88.s6.e0"
}
]
},
{
"id": "4117",
"type": "Species",
"text": [
"human"
],
"offsets": [
[
767,
772
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d88.s6.e1"
}
]
},
{
"id": "4118",
"type": "Diseases",
"text": [
"perirolandic epilepsy"
],
"offsets": [
[
978,
999
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d88.s7.e0"
}
]
},
{
"id": "4119",
"type": "Diseases",
"text": [
"mosaicism"
],
"offsets": [
[
1033,
1042
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d88.s7.e1"
}
]
},
{
"id": "4120",
"type": "Species",
"text": [
"patients"
],
"offsets": [
[
958,
966
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d88.s7.e2"
}
]
},
{
"id": "4121",
"type": "Species",
"text": [
"patients"
],
"offsets": [
[
1141,
1149
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d88.s8.e0"
}
]
}
] | [] | [] | [] |
4220 | miRNA-corp.d89 | [
{
"id": "4123",
"type": "title",
"text": [
"These results indicate that miRNAs are differentially expressed in C. elegans PD models and suggest a role for these molecules in disease pathogenesis. "
],
"offsets": [
[
0,
154
]
]
},
{
"id": "4124",
"type": "abstract",
"text": [
"Here, we show that 12 specific miRNAs are differentially regulated in the animals overexpressing alpha-synuclein, five in cat-1, and three in the pdr-1 mutants. "
],
"offsets": [
[
155,
316
]
]
},
{
"id": "4125",
"type": "abstract",
"text": [
"The family of miR-64 and miR-65 are co-underexpressed in the alpha-synuclein transgenic and cat-1 strains, and members of let-7 family co-underexpressed in the alpha-synuclein and pdr-1 strains; mdl-1 and ptc-1 genes are target candidates for miR-64 and miR-65 and are overexpressed in alpha-synuclein transgenic as well as miR-64/65 (tm3711) knockout animals. "
],
"offsets": [
[
317,
678
]
]
},
{
"id": "4126",
"type": "abstract",
"text": [
"MicroRNAs (miRNAs) play an important role in human brain development and maintenance. "
],
"offsets": [
[
679,
765
]
]
},
{
"id": "4127",
"type": "abstract",
"text": [
"To search for miRNAs that may be involved in the pathogenesis of Parkinsons disease (PD), we utilized miRNA microarrays to identify potential gene expression changes in 115 annotated miRNAs in PD-associated Caenorhabditis elegans models that either overexpress human A53T alpha-synuclein or have mutations within the vesicular catecholamine transporter (cat-1) or parkin (pdr-1) ortholog. "
],
"offsets": [
[
766,
1155
]
]
},
{
"id": "4128",
"type": "abstract",
"text": [
"Global microRNA expression profiling of Caenorhabditis elegans Parkinson's disease models. "
],
"offsets": [
[
1156,
1248
]
]
}
] | [
{
"id": "4129",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
[
28,
34
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d89.s0.e0"
}
]
},
{
"id": "4130",
"type": "Relation_Trigger",
"text": [
"differentially expressed"
],
"offsets": [
[
39,
63
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d89.s0.e1"
}
]
},
{
"id": "4131",
"type": "Diseases",
"text": [
"PD"
],
"offsets": [
[
78,
80
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d89.s0.e2"
}
]
},
{
"id": "4132",
"type": "Species",
"text": [
"C. elegans"
],
"offsets": [
[
67,
77
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d89.s0.e3"
}
]
},
{
"id": "4133",
"type": "Genes/Proteins",
"text": [
"alpha-synuclein"
],
"offsets": [
[
252,
267
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d89.s1.e0"
}
]
},
{
"id": "4134",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
[
186,
192
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d89.s1.e1"
}
]
},
{
"id": "4135",
"type": "Relation_Trigger",
"text": [
"differentially regulated"
],
"offsets": [
[
197,
221
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d89.s1.e2"
}
]
},
{
"id": "4136",
"type": "Relation_Trigger",
"text": [
"overexpressing"
],
"offsets": [
[
237,
251
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d89.s1.e3"
}
]
},
{
"id": "4137",
"type": "Specific_miRNAs",
"text": [
"miR-64"
],
"offsets": [
[
331,
337
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d89.s2.e0"
}
]
},
{
"id": "4138",
"type": "Specific_miRNAs",
"text": [
"miR-65"
],
"offsets": [
[
342,
348
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d89.s2.e1"
}
]
},
{
"id": "4139",
"type": "Genes/Proteins",
"text": [
"mdl-1"
],
"offsets": [
[
512,
517
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d89.s2.e2"
}
]
},
{
"id": "4140",
"type": "Genes/Proteins",
"text": [
"alpha-synuclein"
],
"offsets": [
[
477,
492
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d89.s2.e3"
}
]
},
{
"id": "4141",
"type": "Specific_miRNAs",
"text": [
"miR-64"
],
"offsets": [
[
560,
566
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d89.s2.e4"
}
]
},
{
"id": "4142",
"type": "Specific_miRNAs",
"text": [
"miR-65"
],
"offsets": [
[
571,
577
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d89.s2.e5"
}
]
},
{
"id": "4143",
"type": "Genes/Proteins",
"text": [
"alpha-synuclein"
],
"offsets": [
[
603,
618
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d89.s2.e6"
}
]
},
{
"id": "4144",
"type": "Genes/Proteins",
"text": [
"ptc-1"
],
"offsets": [
[
522,
527
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d89.s2.e7"
}
]
},
{
"id": "4145",
"type": "Genes/Proteins",
"text": [
"alpha-synuclein"
],
"offsets": [
[
378,
393
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d89.s2.e8"
}
]
},
{
"id": "4146",
"type": "Relation_Trigger",
"text": [
"co-underexpressed"
],
"offsets": [
[
353,
370
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d89.s2.e9"
}
]
},
{
"id": "4147",
"type": "Relation_Trigger",
"text": [
"co-underexpressed"
],
"offsets": [
[
452,
469
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d89.s2.e10"
}
]
},
{
"id": "4148",
"type": "Relation_Trigger",
"text": [
"target candidates"
],
"offsets": [
[
538,
555
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d89.s2.e11"
}
]
},
{
"id": "4149",
"type": "Relation_Trigger",
"text": [
"overexpressed"
],
"offsets": [
[
586,
599
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d89.s2.e12"
}
]
},
{
"id": "4150",
"type": "Specific_miRNAs",
"text": [
"let-7"
],
"offsets": [
[
439,
444
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d89.s2.e13"
}
]
},
{
"id": "4151",
"type": "Specific_miRNAs",
"text": [
"miR"
],
"offsets": [
[
342,
345
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d89.s2.e14"
}
]
},
{
"id": "4152",
"type": "Specific_miRNAs",
"text": [
"miR-64/65"
],
"offsets": [
[
641,
650
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d89.s2.e15"
}
]
},
{
"id": "4153",
"type": "Non-Specific_miRNAs",
"text": [
"MicroRNAs"
],
"offsets": [
[
679,
688
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d89.s3.e0"
}
]
},
{
"id": "4154",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
[
690,
696
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d89.s3.e1"
}
]
},
{
"id": "4155",
"type": "Species",
"text": [
"human"
],
"offsets": [
[
724,
729
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d89.s3.e2"
}
]
},
{
"id": "4156",
"type": "Diseases",
"text": [
"Parkinsons disease"
],
"offsets": [
[
831,
849
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d89.s4.e0"
}
]
},
{
"id": "4157",
"type": "Diseases",
"text": [
"PD"
],
"offsets": [
[
851,
853
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d89.s4.e1"
}
]
},
{
"id": "4158",
"type": "Genes/Proteins",
"text": [
"A53T alpha-synuclein"
],
"offsets": [
[
1033,
1053
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
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] | [] | [] | [
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"arg2_id": "miRNA-corp.d89.s5.e0",
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}
] |
4243 | miRNA-corp.d90 | [
{
"id": "4221",
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],
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804,
1062
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}
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180
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337,
347
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379,
385
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453
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511
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533
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]
}
] | [] | [] | [] |
4262 | miRNA-corp.d91 | [
{
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"type": "title",
"text": [
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153
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{
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192
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{
"id": "4246",
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"text": [
"Widespread A-to-I modification of repeat sequences in the human transcriptome suggests additional roles for RNA editing and links it to other processes of gene regulation, such as RNA splicing as well as siRNA mediated gene silencing and miRNA function. "
],
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[
193,
447
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]
},
{
"id": "4247",
"type": "abstract",
"text": [
"The deficiency or misregulation of editing has been implicated in the etiology of neurological diseases, such as epilepsy, amyotrophic lateral sclerosis (ALS), depression and tumor progression. "
],
"offsets": [
[
448,
642
]
]
},
{
"id": "4248",
"type": "abstract",
"text": [
"Also, it regulates important functional properties of neurotransmitter receptor genes in the central nervous system by changing single codons in pre-mRNA. "
],
"offsets": [
[
643,
798
]
]
}
] | [
{
"id": "4249",
"type": "Relation_Trigger",
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"regulation of gene expression"
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[
80,
109
]
],
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{
"id": "4250",
"type": "Relation_Trigger",
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"regulation"
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159,
169
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},
{
"id": "4251",
"type": "Non-Specific_miRNAs",
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"miRNA"
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431,
436
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"id": "4252",
"type": "Relation_Trigger",
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"regulation"
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353,
363
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},
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"id": "4253",
"type": "Species",
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"human"
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251,
256
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"db_id": "miRNA-corp.d91.s3.e2"
}
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},
{
"id": "4254",
"type": "Diseases",
"text": [
"neurological diseases"
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[
530,
551
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{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d91.s4.e0"
}
]
},
{
"id": "4255",
"type": "Diseases",
"text": [
"epilepsy"
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[
561,
569
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{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d91.s4.e1"
}
]
},
{
"id": "4256",
"type": "Diseases",
"text": [
"amyotrophic lateral sclerosis"
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[
571,
600
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"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d91.s4.e2"
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},
{
"id": "4257",
"type": "Diseases",
"text": [
"ALS"
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[
602,
605
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"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d91.s4.e3"
}
]
},
{
"id": "4258",
"type": "Diseases",
"text": [
"depression"
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[
608,
618
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d91.s4.e4"
}
]
},
{
"id": "4259",
"type": "Diseases",
"text": [
"tumor"
],
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[
623,
628
]
],
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"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d91.s4.e5"
}
]
},
{
"id": "4260",
"type": "Relation_Trigger",
"text": [
"misregulation"
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[
466,
479
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"db_id": "miRNA-corp.d91.s4.e6"
}
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},
{
"id": "4261",
"type": "Relation_Trigger",
"text": [
"regulates"
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652,
661
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{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d91.s5.e0"
}
]
}
] | [] | [] | [] |
4314 | miRNA-corp.d92 | [
{
"id": "4263",
"type": "title",
"text": [
"New insights into the roles of microRNAs in drug addiction and neuroplasticity. "
],
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[
0,
81
]
]
},
{
"id": "4264",
"type": "abstract",
"text": [
"In this review, the aim is to provide an overview of the emerging role of miRNAs in addiction. "
],
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[
82,
179
]
]
},
{
"id": "4265",
"type": "abstract",
"text": [
"miRNAs are small non-coding RNAs, particularly abundant in the nervous system, that play key roles as regulatory molecules in processes such as neurogenesis, synapse development and plasticity in the brain. "
],
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[
180,
387
]
]
},
{
"id": "4266",
"type": "abstract",
"text": [
"They also act as key spatiotemporal regulators during dendritic morphogenesis, controlling the expression of hundreds of genes involved in neuroplasticity and in the function of synapses. "
],
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[
388,
576
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]
},
{
"id": "4267",
"type": "abstract",
"text": [
"Recent studies have identified changes of several specific miRNA expression profiles and polymorphisms affecting the interactions between miRNAs and their targets in various brain disorders, including addiction: miR-16 causes adaptive changes in production of the serotonin transporter; miR-133b is specifically expressed in midbrain dopaminergic neurons, and regulates the production of tyrosine hydroxylase and the dopamine transporter; miR-212 affects production of striatal brain-derived neurotrophic factor and synaptic plasticity upon cocaine. "
],
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[
577,
1127
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]
},
{
"id": "4268",
"type": "abstract",
"text": [
"Clearly, specific miRNAs have emerged as key regulators leading to addiction, and could serve as valuable targets for more efficient therapies. "
],
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[
1128,
1272
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]
},
{
"id": "4269",
"type": "abstract",
"text": [
"ABSTRACT : Drug addiction is a major public health issue. "
],
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[
1273,
1331
]
]
},
{
"id": "4270",
"type": "abstract",
"text": [
"It is typically a multigenetic brain disorder, implying combined changes of expression of several hundred genes. "
],
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[
1332,
1445
]
]
},
{
"id": "4271",
"type": "abstract",
"text": [
"Psychostimulants (such as cocaine, heroin and amphetamines) induce strong and persistent neuroadaptive changes through a surfeit of gene regulatory mechanisms leading to addiction. "
],
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[
1446,
1627
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]
},
{
"id": "4272",
"type": "abstract",
"text": [
"Activity-dependent synaptic plasticity of the mesolimbic dopaminergic system, known as the 'reward pathway', plays a crucial role in the development of drug dependence. "
],
"offsets": [
[
1628,
1797
]
]
}
] | [
{
"id": "4273",
"type": "Non-Specific_miRNAs",
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"microRNAs"
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[
31,
40
]
],
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}
]
},
{
"id": "4274",
"type": "Diseases",
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"drug addiction"
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44,
58
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]
},
{
"id": "4275",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
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156,
162
]
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"db_id": "miRNA-corp.d92.s1.e0"
}
]
},
{
"id": "4276",
"type": "Non-Specific_miRNAs",
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[
180,
186
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"db_id": "miRNA-corp.d92.s2.e0"
}
]
},
{
"id": "4277",
"type": "Relation_Trigger",
"text": [
"regulatory molecules"
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[
282,
302
]
],
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}
]
},
{
"id": "4278",
"type": "Relation_Trigger",
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424,
434
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}
]
},
{
"id": "4279",
"type": "Non-Specific_miRNAs",
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636,
641
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]
},
{
"id": "4280",
"type": "Non-Specific_miRNAs",
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715,
721
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}
]
},
{
"id": "4281",
"type": "Diseases",
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751,
766
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}
]
},
{
"id": "4282",
"type": "Specific_miRNAs",
"text": [
"miR-16"
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[
789,
795
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"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d92.s4.e3"
}
]
},
{
"id": "4283",
"type": "Specific_miRNAs",
"text": [
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[
1016,
1023
]
],
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"db_id": "miRNA-corp.d92.s4.e4"
}
]
},
{
"id": "4284",
"type": "Specific_miRNAs",
"text": [
"miR-133b"
],
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[
864,
872
]
],
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"db_id": "miRNA-corp.d92.s4.e5"
}
]
},
{
"id": "4285",
"type": "Relation_Trigger",
"text": [
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[
876,
898
]
],
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}
]
},
{
"id": "4286",
"type": "Relation_Trigger",
"text": [
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937,
946
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"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d92.s4.e7"
}
]
},
{
"id": "4287",
"type": "Relation_Trigger",
"text": [
"targets"
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732,
739
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}
]
},
{
"id": "4288",
"type": "Genes/Proteins",
"text": [
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1055,
1088
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],
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}
]
},
{
"id": "4289",
"type": "Genes/Proteins",
"text": [
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[
965,
985
]
],
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"db_id": "miRNA-corp.d92.s4.e10"
}
]
},
{
"id": "4290",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
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1146,
1152
]
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}
]
},
{
"id": "4291",
"type": "Relation_Trigger",
"text": [
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1173,
1183
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}
]
},
{
"id": "4292",
"type": "Relation_Trigger",
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"targets"
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1234,
1241
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"db_id": "miRNA-corp.d92.s5.e2"
}
]
},
{
"id": "4293",
"type": "Diseases",
"text": [
"Drug addiction"
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1284,
1298
]
],
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"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d92.s6.e0"
}
]
},
{
"id": "4294",
"type": "Diseases",
"text": [
"brain disorder"
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1363,
1377
]
],
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"db_id": "miRNA-corp.d92.s7.e0"
}
]
},
{
"id": "4295",
"type": "Relation_Trigger",
"text": [
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[
1397,
1418
]
],
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"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d92.s7.e1"
}
]
},
{
"id": "4296",
"type": "Relation_Trigger",
"text": [
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1583,
1593
]
],
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{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d92.s8.e0"
}
]
},
{
"id": "4297",
"type": "Diseases",
"text": [
"drug dependence"
],
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[
1780,
1795
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d92.s9.e0"
}
]
}
] | [] | [] | [
{
"id": "4298",
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"arg2_id": "miRNA-corp.d92.s0.e1",
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},
{
"id": "4299",
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},
{
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"normalized": []
},
{
"id": "4301",
"type": "Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d92.s4.e5",
"arg2_id": "miRNA-corp.d92.s4.e2",
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},
{
"id": "4302",
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"normalized": []
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{
"id": "4303",
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},
{
"id": "4304",
"type": "Non-Specific_miRNAs-Diseases",
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{
"id": "4305",
"type": "Non-Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d92.s4.e1",
"arg2_id": "miRNA-corp.d92.s4.e9",
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},
{
"id": "4306",
"type": "Non-Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d92.s4.e1",
"arg2_id": "miRNA-corp.d92.s4.e10",
"normalized": []
},
{
"id": "4307",
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"arg2_id": "miRNA-corp.d92.s4.e2",
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},
{
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"normalized": []
},
{
"id": "4309",
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"arg2_id": "miRNA-corp.d92.s4.e10",
"normalized": []
},
{
"id": "4310",
"type": "Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d92.s4.e3",
"arg2_id": "miRNA-corp.d92.s4.e2",
"normalized": []
},
{
"id": "4311",
"type": "Specific_miRNAs-Genes/Proteins",
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},
{
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},
{
"id": "4313",
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"arg1_id": "miRNA-corp.d92.s4.e4",
"arg2_id": "miRNA-corp.d92.s4.e2",
"normalized": []
}
] |
4334 | miRNA-corp.d93 | [
{
"id": "4315",
"type": "title",
"text": [
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],
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[
0,
208
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]
},
{
"id": "4316",
"type": "abstract",
"text": [
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],
"offsets": [
[
209,
405
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]
},
{
"id": "4317",
"type": "abstract",
"text": [
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],
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406,
459
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]
},
{
"id": "4318",
"type": "abstract",
"text": [
"MicroRNAs (miRNAs) are now recognized as the primary RNAs involved in the purposeful silencing of the cell's own message. "
],
"offsets": [
[
460,
582
]
]
}
] | [
{
"id": "4319",
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49,
55
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}
]
},
{
"id": "4320",
"type": "Diseases",
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104,
120
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],
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}
]
},
{
"id": "4321",
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92,
99
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],
"normalized": [
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}
]
},
{
"id": "4322",
"type": "Relation_Trigger",
"text": [
"inhibitors"
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[
178,
188
]
],
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}
]
},
{
"id": "4323",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
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248,
254
]
],
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{
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}
]
},
{
"id": "4324",
"type": "Relation_Trigger",
"text": [
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272,
282
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
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}
]
},
{
"id": "4325",
"type": "Diseases",
"text": [
"cancer"
],
"offsets": [
[
397,
403
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d93.s1.e2"
}
]
},
{
"id": "4326",
"type": "Non-Specific_miRNAs",
"text": [
"microRNAs"
],
"offsets": [
[
424,
433
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d93.s2.e0"
}
]
},
{
"id": "4327",
"type": "Diseases",
"text": [
"brain tumor"
],
"offsets": [
[
437,
448
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d93.s2.e1"
}
]
},
{
"id": "4328",
"type": "Non-Specific_miRNAs",
"text": [
"MicroRNAs"
],
"offsets": [
[
460,
469
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d93.s3.e0"
}
]
},
{
"id": "4329",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
[
471,
477
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d93.s3.e1"
}
]
}
] | [] | [] | [
{
"id": "4330",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d93.s0.e0",
"arg2_id": "miRNA-corp.d93.s0.e1",
"normalized": []
},
{
"id": "4331",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d93.s0.e0",
"arg2_id": "miRNA-corp.d93.s0.e2",
"normalized": []
},
{
"id": "4332",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d93.s1.e0",
"arg2_id": "miRNA-corp.d93.s1.e2",
"normalized": []
},
{
"id": "4333",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d93.s2.e0",
"arg2_id": "miRNA-corp.d93.s2.e1",
"normalized": []
}
] |
4391 | miRNA-corp.d94 | [
{
"id": "4335",
"type": "title",
"text": [
"Micro RNAs (miRNAs) are post-transcriptional modulators of gene expression that regulate the stability and translation of their target messenger RNAs (mRNAs). "
],
"offsets": [
[
0,
159
]
]
},
{
"id": "4336",
"type": "abstract",
"text": [
"Micro RNA-125b (miRNA-125b) function in astrogliosis and glial cell proliferation. "
],
"offsets": [
[
160,
244
]
]
},
{
"id": "4337",
"type": "abstract",
"text": [
"In vitro, anti-miRNA-125b added exogenously to IL-6-stressed NHA cultures attenuated both glial cell proliferation and increased the expression of the cyclin-dependent kinase inhibitor 2A (CDKN2A), a miRNA-125b target and negative regulator of cell growth. "
],
"offsets": [
[
245,
502
]
]
},
{
"id": "4338",
"type": "abstract",
"text": [
"Here we report that the levels of a human brain-enriched miRNA-125b are up-regulated in interleukin-6 (IL-6)-stressed normal human astrocytes (NHA), a treatment known to induce astrogliosis. "
],
"offsets": [
[
503,
694
]
]
},
{
"id": "4339",
"type": "abstract",
"text": [
"The results suggest that miRNA-125b up-regulation contributes to astrogliosis and to defects in the cell cycle that are characteristic of degenerating brain tissues. "
],
"offsets": [
[
695,
863
]
]
},
{
"id": "4340",
"type": "abstract",
"text": [
"A strong positive correlation between miRNA-125b abundance and the glial cell markers glial fibrillary acidic protein (GFAP) and vimentin, and CDKN2A down-regulation was noted in advanced Alzheimer's disease (AD) and in Down's syndrome (DS) brain, chronic neurological disorders associated with astrogliosis. "
],
"offsets": [
[
864,
1173
]
]
}
] | [
{
"id": "4341",
"type": "Non-Specific_miRNAs",
"text": [
"Micro RNAs"
],
"offsets": [
[
0,
10
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d94.s0.e0"
}
]
},
{
"id": "4342",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
[
12,
18
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d94.s0.e1"
}
]
},
{
"id": "4343",
"type": "Relation_Trigger",
"text": [
"regulate"
],
"offsets": [
[
80,
88
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d94.s0.e2"
}
]
},
{
"id": "4344",
"type": "Relation_Trigger",
"text": [
"modulators of gene expression"
],
"offsets": [
[
45,
74
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d94.s0.e3"
}
]
},
{
"id": "4345",
"type": "Relation_Trigger",
"text": [
"target"
],
"offsets": [
[
128,
134
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d94.s0.e4"
}
]
},
{
"id": "4346",
"type": "Specific_miRNAs",
"text": [
"Micro RNA-125b"
],
"offsets": [
[
160,
174
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d94.s1.e0"
}
]
},
{
"id": "4347",
"type": "Specific_miRNAs",
"text": [
"miRNA-125b"
],
"offsets": [
[
176,
186
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d94.s1.e1"
}
]
},
{
"id": "4348",
"type": "Genes/Proteins",
"text": [
"IL-6"
],
"offsets": [
[
292,
296
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d94.s2.e0"
}
]
},
{
"id": "4349",
"type": "Relation_Trigger",
"text": [
"target"
],
"offsets": [
[
456,
462
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d94.s2.e1"
}
]
},
{
"id": "4350",
"type": "Relation_Trigger",
"text": [
"increased the expression"
],
"offsets": [
[
364,
388
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d94.s2.e2"
}
]
},
{
"id": "4351",
"type": "Specific_miRNAs",
"text": [
"miRNA-125b"
],
"offsets": [
[
445,
455
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d94.s2.e3"
}
]
},
{
"id": "4352",
"type": "Genes/Proteins",
"text": [
"cyclin-dependent kinase inhibitor 2A"
],
"offsets": [
[
396,
432
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d94.s2.e4"
}
]
},
{
"id": "4353",
"type": "Genes/Proteins",
"text": [
"CDKN2A"
],
"offsets": [
[
434,
440
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d94.s2.e5"
}
]
},
{
"id": "4354",
"type": "Relation_Trigger",
"text": [
"attenuated"
],
"offsets": [
[
319,
329
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d94.s2.e6"
}
]
},
{
"id": "4355",
"type": "Relation_Trigger",
"text": [
"negative regulator"
],
"offsets": [
[
467,
485
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d94.s2.e7"
}
]
},
{
"id": "4356",
"type": "Relation_Trigger",
"text": [
"up-regulated"
],
"offsets": [
[
575,
587
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d94.s3.e0"
}
]
},
{
"id": "4357",
"type": "Specific_miRNAs",
"text": [
"miRNA-125b"
],
"offsets": [
[
560,
570
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d94.s3.e1"
}
]
},
{
"id": "4358",
"type": "Genes/Proteins",
"text": [
"interleukin-6"
],
"offsets": [
[
591,
604
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d94.s3.e2"
}
]
},
{
"id": "4359",
"type": "Genes/Proteins",
"text": [
"IL-6"
],
"offsets": [
[
606,
610
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d94.s3.e3"
}
]
},
{
"id": "4360",
"type": "Species",
"text": [
"human"
],
"offsets": [
[
539,
544
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d94.s3.e4"
}
]
},
{
"id": "4361",
"type": "Species",
"text": [
"human"
],
"offsets": [
[
628,
633
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d94.s3.e5"
}
]
},
{
"id": "4362",
"type": "Relation_Trigger",
"text": [
"up-regulation"
],
"offsets": [
[
731,
744
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d94.s4.e0"
}
]
},
{
"id": "4363",
"type": "Specific_miRNAs",
"text": [
"miRNA-125b"
],
"offsets": [
[
720,
730
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d94.s4.e1"
}
]
},
{
"id": "4364",
"type": "Genes/Proteins",
"text": [
"vimentin"
],
"offsets": [
[
993,
1001
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d94.s5.e0"
}
]
},
{
"id": "4365",
"type": "Relation_Trigger",
"text": [
"positive correlation"
],
"offsets": [
[
873,
893
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d94.s5.e1"
}
]
},
{
"id": "4366",
"type": "Diseases",
"text": [
"Alzheimer's disease"
],
"offsets": [
[
1052,
1071
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d94.s5.e2"
}
]
},
{
"id": "4367",
"type": "Diseases",
"text": [
"AD"
],
"offsets": [
[
1073,
1075
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d94.s5.e3"
}
]
},
{
"id": "4368",
"type": "Diseases",
"text": [
"Down's syndrome"
],
"offsets": [
[
1084,
1099
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d94.s5.e4"
}
]
},
{
"id": "4369",
"type": "Diseases",
"text": [
"DS"
],
"offsets": [
[
1101,
1103
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d94.s5.e5"
}
]
},
{
"id": "4370",
"type": "Genes/Proteins",
"text": [
"glial fibrillary acidic protein"
],
"offsets": [
[
950,
981
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d94.s5.e6"
}
]
},
{
"id": "4371",
"type": "Genes/Proteins",
"text": [
"GFAP"
],
"offsets": [
[
983,
987
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d94.s5.e7"
}
]
},
{
"id": "4372",
"type": "Genes/Proteins",
"text": [
"CDKN2A"
],
"offsets": [
[
1007,
1013
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d94.s5.e8"
}
]
},
{
"id": "4373",
"type": "Specific_miRNAs",
"text": [
"miRNA-125b"
],
"offsets": [
[
902,
912
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d94.s5.e9"
}
]
},
{
"id": "4374",
"type": "Relation_Trigger",
"text": [
"down-regulation"
],
"offsets": [
[
1014,
1029
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d94.s5.e10"
}
]
},
{
"id": "4375",
"type": "Relation_Trigger",
"text": [
"associated"
],
"offsets": [
[
1143,
1153
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d94.s5.e11"
}
]
},
{
"id": "4376",
"type": "Diseases",
"text": [
"neurological disorders"
],
"offsets": [
[
1120,
1142
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d94.s5.e12"
}
]
}
] | [] | [] | [
{
"id": "4377",
"type": "Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d94.s2.e3",
"arg2_id": "miRNA-corp.d94.s2.e0",
"normalized": []
},
{
"id": "4378",
"type": "Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d94.s2.e3",
"arg2_id": "miRNA-corp.d94.s2.e4",
"normalized": []
},
{
"id": "4379",
"type": "Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d94.s2.e3",
"arg2_id": "miRNA-corp.d94.s2.e5",
"normalized": []
},
{
"id": "4380",
"type": "Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d94.s3.e1",
"arg2_id": "miRNA-corp.d94.s3.e2",
"normalized": []
},
{
"id": "4381",
"type": "Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d94.s3.e1",
"arg2_id": "miRNA-corp.d94.s3.e3",
"normalized": []
},
{
"id": "4382",
"type": "Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d94.s5.e9",
"arg2_id": "miRNA-corp.d94.s5.e2",
"normalized": []
},
{
"id": "4383",
"type": "Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d94.s5.e9",
"arg2_id": "miRNA-corp.d94.s5.e3",
"normalized": []
},
{
"id": "4384",
"type": "Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d94.s5.e9",
"arg2_id": "miRNA-corp.d94.s5.e4",
"normalized": []
},
{
"id": "4385",
"type": "Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d94.s5.e9",
"arg2_id": "miRNA-corp.d94.s5.e5",
"normalized": []
},
{
"id": "4386",
"type": "Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d94.s5.e9",
"arg2_id": "miRNA-corp.d94.s5.e6",
"normalized": []
},
{
"id": "4387",
"type": "Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d94.s5.e9",
"arg2_id": "miRNA-corp.d94.s5.e7",
"normalized": []
},
{
"id": "4388",
"type": "Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d94.s5.e9",
"arg2_id": "miRNA-corp.d94.s5.e8",
"normalized": []
},
{
"id": "4389",
"type": "Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d94.s5.e9",
"arg2_id": "miRNA-corp.d94.s5.e0",
"normalized": []
},
{
"id": "4390",
"type": "Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d94.s5.e9",
"arg2_id": "miRNA-corp.d94.s5.e12",
"normalized": []
}
] |
4427 | miRNA-corp.d95 | [
{
"id": "4392",
"type": "title",
"text": [
"PURPOSE Medulloblastomas are heterogeneous tumors that collectively represent the most common malignant brain tumor in children. "
],
"offsets": [
[
0,
129
]
]
},
{
"id": "4393",
"type": "abstract",
"text": [
"Integrative genomic analysis of medulloblastoma identifies a molecular subgroup that drives poor clinical outcome. "
],
"offsets": [
[
130,
246
]
]
},
{
"id": "4394",
"type": "abstract",
"text": [
"We reveal the relative contribution of each subgroup to clinical outcome as a whole and show that a previously unidentified molecular subgroup, characterized genetically by c-MYC copy number gains and transcriptionally by enrichment of photoreceptor pathways and increased miR-183∼96∼182 expression, is associated with significantly lower rates of event-free and overall survivals. "
],
"offsets": [
[
247,
629
]
]
},
{
"id": "4395",
"type": "abstract",
"text": [
"Results Identified are six molecular subgroups of medulloblastoma, each with a unique combination of numerical and structural chromosomal aberrations that globally influence mRNA and miRNA expression. "
],
"offsets": [
[
630,
831
]
]
},
{
"id": "4396",
"type": "abstract",
"text": [
"CONCLUSION Our results detail the complex genomic heterogeneity of medulloblastomas and identify a previously unrecognized molecular subgroup with poor clinical outcome for which more effective therapeutic strategies should be developed. "
],
"offsets": [
[
832,
1072
]
]
},
{
"id": "4397",
"type": "abstract",
"text": [
"PATIENTS AND METHODS We profiled the mRNA transcriptome of 194 medulloblastomas and performed high-density single nucleotide polymorphism array and miRNA analysis on 115 and 98 of these, respectively. "
],
"offsets": [
[
1073,
1274
]
]
},
{
"id": "4398",
"type": "abstract",
"text": [
"To understand the molecular characteristics underlying their heterogeneity and to identify whether such characteristics represent risk factors for patients with this disease, we performed an integrated genomic analysis of a large series of primary tumors. "
],
"offsets": [
[
1275,
1531
]
]
},
{
"id": "4399",
"type": "abstract",
"text": [
"We additionally validated our findings in three previously published independent medulloblastoma data sets. "
],
"offsets": [
[
1532,
1640
]
]
},
{
"id": "4400",
"type": "abstract",
"text": [
"Non-negative matrix factorization-based clustering of mRNA expression data was used to identify molecular subgroups of medulloblastoma; DNA copy number, miRNA profiles, and clinical outcomes were analyzed for each. "
],
"offsets": [
[
1641,
1856
]
]
}
] | [
{
"id": "4401",
"type": "Diseases",
"text": [
"brain tumor"
],
"offsets": [
[
104,
115
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d95.s0.e0"
}
]
},
{
"id": "4402",
"type": "Diseases",
"text": [
"Medulloblastomas"
],
"offsets": [
[
8,
24
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d95.s0.e1"
}
]
},
{
"id": "4403",
"type": "Diseases",
"text": [
"tumors"
],
"offsets": [
[
43,
49
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d95.s0.e2"
}
]
},
{
"id": "4404",
"type": "Species",
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127
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}
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},
{
"id": "4405",
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162,
177
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]
},
{
"id": "4406",
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"MYC"
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422,
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}
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},
{
"id": "4407",
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"miR-183∼96∼182"
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520,
534
]
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}
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},
{
"id": "4408",
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"associated"
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550,
560
]
],
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}
]
},
{
"id": "4409",
"type": "Relation_Trigger",
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"increased miR-183∼96∼182 expression"
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510,
545
]
],
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{
"db_name": "miRNA-corpus",
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}
]
},
{
"id": "4410",
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"miRNA"
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813,
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}
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},
{
"id": "4411",
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"medulloblastoma"
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}
]
},
{
"id": "4412",
"type": "Diseases",
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"chromosomal aberrations"
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756,
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}
]
},
{
"id": "4413",
"type": "Diseases",
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"medulloblastomas"
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899,
915
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}
]
},
{
"id": "4414",
"type": "Non-Specific_miRNAs",
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"miRNA"
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1221,
1226
]
],
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"db_name": "miRNA-corpus",
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}
]
},
{
"id": "4415",
"type": "Diseases",
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"medulloblastomas"
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1136,
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}
]
},
{
"id": "4416",
"type": "Species",
"text": [
"PATIENTS"
],
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1073,
1081
]
],
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"db_name": "miRNA-corpus",
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}
]
},
{
"id": "4417",
"type": "Diseases",
"text": [
"tumors"
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1523,
1529
]
],
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"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d95.s6.e0"
}
]
},
{
"id": "4418",
"type": "Species",
"text": [
"patients"
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1422,
1430
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d95.s6.e1"
}
]
},
{
"id": "4419",
"type": "Diseases",
"text": [
"medulloblastoma"
],
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1613,
1628
]
],
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{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d95.s7.e0"
}
]
},
{
"id": "4420",
"type": "Non-Specific_miRNAs",
"text": [
"miRNA"
],
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1794,
1799
]
],
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{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d95.s8.e0"
}
]
},
{
"id": "4421",
"type": "Diseases",
"text": [
"medulloblastoma"
],
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1760,
1775
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d95.s8.e1"
}
]
}
] | [] | [] | [
{
"id": "4422",
"type": "Specific_miRNAs-Genes/Proteins",
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"arg2_id": "miRNA-corp.d95.s2.e0",
"normalized": []
},
{
"id": "4423",
"type": "Non-Specific_miRNAs-Diseases",
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},
{
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},
{
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},
{
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"arg2_id": "miRNA-corp.d95.s8.e1",
"normalized": []
}
] |
4476 | miRNA-corp.d96 | [
{
"id": "4428",
"type": "title",
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"MicroRNAs and apoptosis: implications in the molecular therapy of human disease. "
],
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0,
82
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]
},
{
"id": "4429",
"type": "abstract",
"text": [
"1. MicroRNAs (miRNAs), the small non-coding RNAs of approximately 22 nucleotides, are now recognized as a very large family present throughout the genomes of plants and metazoans. "
],
"offsets": [
[
83,
263
]
]
},
{
"id": "4430",
"type": "abstract",
"text": [
"These small transcripts modulate protein expression by binding to complementary or partially complementary target protein-coding mRNAs and targeting them for degradation or translational inhibition. "
],
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264,
463
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]
},
{
"id": "4431",
"type": "abstract",
"text": [
"2. The discovery of miRNAs has revolutionized our understanding of the mechanisms that regulate gene expression, with the addition of an entirely novel level of regulatory control. "
],
"offsets": [
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464,
645
]
]
},
{
"id": "4432",
"type": "abstract",
"text": [
"3. One of the most active fields of miRNA research is miRNA regulation of apoptosis, a programmed cell death implicated in many human diseases, such as cancer, Alzheimer's disease, hypertrophy and heart failure. "
],
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[
646,
858
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]
},
{
"id": "4433",
"type": "abstract",
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"Indeed, aberrant miRNA expression has been documented in human disease as well as in animal models, with evidence for a causative role in tumourigenesis. "
],
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859,
1013
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]
},
{
"id": "4434",
"type": "abstract",
"text": [
"We now know that miRNAs play pivotal roles in diverse processes, such as development and differentiation, control of cell proliferation and death, stress response and metabolism. "
],
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1014,
1193
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]
},
{
"id": "4435",
"type": "abstract",
"text": [
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],
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1194,
1291
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]
},
{
"id": "4436",
"type": "abstract",
"text": [
"4. The present review provides a comprehensive summary and analysis of the currently available data, focusing on the transcriptional controls, target genes and signalling pathways linking the apoptosis-regulating miRNAs and apoptotic cell death. "
],
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1292,
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]
},
{
"id": "4437",
"type": "abstract",
"text": [
"Thus far, nearly 30 of 500 human miRNAs have been validated experimentally to regulate apoptosis; this number is likely to increase with future studies. "
],
"offsets": [
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1541,
1694
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]
}
] | [
{
"id": "4438",
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0,
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},
{
"id": "4439",
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{
"id": "4440",
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"id": "4441",
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371,
377
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}
]
},
{
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403,
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]
},
{
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437,
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}
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},
{
"id": "4445",
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288,
315
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}
]
},
{
"id": "4446",
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319,
329
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"db_id": "miRNA-corp.d96.s2.e4"
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]
},
{
"id": "4447",
"type": "Non-Specific_miRNAs",
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"miRNAs"
],
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484,
490
]
],
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}
]
},
{
"id": "4448",
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551,
575
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}
]
},
{
"id": "4449",
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616,
635
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"db_id": "miRNA-corp.d96.s3.e2"
}
]
},
{
"id": "4450",
"type": "Non-Specific_miRNAs",
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"miRNA"
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682,
687
]
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}
]
},
{
"id": "4451",
"type": "Non-Specific_miRNAs",
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],
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700,
705
]
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"db_id": "miRNA-corp.d96.s4.e1"
}
]
},
{
"id": "4452",
"type": "Diseases",
"text": [
"Alzheimer's disease"
],
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[
806,
825
]
],
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"db_id": "miRNA-corp.d96.s4.e2"
}
]
},
{
"id": "4453",
"type": "Diseases",
"text": [
"hypertrophy"
],
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[
827,
838
]
],
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"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d96.s4.e3"
}
]
},
{
"id": "4454",
"type": "Diseases",
"text": [
"heart failure"
],
"offsets": [
[
843,
856
]
],
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{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d96.s4.e4"
}
]
},
{
"id": "4455",
"type": "Relation_Trigger",
"text": [
"regulation"
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[
706,
716
]
],
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{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d96.s4.e5"
}
]
},
{
"id": "4456",
"type": "Diseases",
"text": [
"cancer"
],
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[
798,
804
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d96.s4.e6"
}
]
},
{
"id": "4457",
"type": "Species",
"text": [
"human"
],
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[
774,
779
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d96.s4.e7"
}
]
},
{
"id": "4458",
"type": "Non-Specific_miRNAs",
"text": [
"miRNA"
],
"offsets": [
[
876,
881
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d96.s5.e0"
}
]
},
{
"id": "4459",
"type": "Relation_Trigger",
"text": [
"aberrant miRNA expression"
],
"offsets": [
[
867,
892
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d96.s5.e1"
}
]
},
{
"id": "4460",
"type": "Species",
"text": [
"human"
],
"offsets": [
[
916,
921
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d96.s5.e2"
}
]
},
{
"id": "4461",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
[
1031,
1037
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d96.s6.e0"
}
]
},
{
"id": "4462",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
[
1222,
1228
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d96.s7.e0"
}
]
},
{
"id": "4463",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
[
1505,
1511
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d96.s8.e0"
}
]
},
{
"id": "4464",
"type": "Relation_Trigger",
"text": [
"target"
],
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[
1435,
1441
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d96.s8.e1"
}
]
},
{
"id": "4465",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
[
1574,
1580
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d96.s9.e0"
}
]
},
{
"id": "4466",
"type": "Relation_Trigger",
"text": [
"regulate"
],
"offsets": [
[
1619,
1627
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d96.s9.e1"
}
]
},
{
"id": "4467",
"type": "Species",
"text": [
"human"
],
"offsets": [
[
1568,
1573
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d96.s9.e2"
}
]
}
] | [] | [] | [
{
"id": "4468",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d96.s4.e0",
"arg2_id": "miRNA-corp.d96.s4.e2",
"normalized": []
},
{
"id": "4469",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d96.s4.e0",
"arg2_id": "miRNA-corp.d96.s4.e3",
"normalized": []
},
{
"id": "4470",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d96.s4.e0",
"arg2_id": "miRNA-corp.d96.s4.e4",
"normalized": []
},
{
"id": "4471",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d96.s4.e0",
"arg2_id": "miRNA-corp.d96.s4.e6",
"normalized": []
},
{
"id": "4472",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d96.s4.e1",
"arg2_id": "miRNA-corp.d96.s4.e2",
"normalized": []
},
{
"id": "4473",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d96.s4.e1",
"arg2_id": "miRNA-corp.d96.s4.e3",
"normalized": []
},
{
"id": "4474",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d96.s4.e1",
"arg2_id": "miRNA-corp.d96.s4.e4",
"normalized": []
},
{
"id": "4475",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d96.s4.e1",
"arg2_id": "miRNA-corp.d96.s4.e6",
"normalized": []
}
] |
4501 | miRNA-corp.d97 | [
{
"id": "4477",
"type": "title",
"text": [
"Additionally, several research groups have established that inserting microRNA (miRNA)-targeted sequences into the adenoviral genome can modulate adenoviral protein expression to confer tissue and tumor selectivity. "
],
"offsets": [
[
0,
216
]
]
},
{
"id": "4478",
"type": "abstract",
"text": [
"This review discusses three aspects of the use of oncolytic adenoviruses to treat cancer: (i) the induction of autophagy and autophagic cell death during adenoviral replication; (ii) the opportunities and strategies involved in the exploitation of miRNA specificity to generate tissue- and tumor-selective oncolytic viruses; and (iii) the rationale for combining oncolytic adenoviruses with chemotherapeutic agents. "
],
"offsets": [
[
217,
635
]
]
},
{
"id": "4479",
"type": "abstract",
"text": [
"Furthermore, the capability of adenoviruses to inhibit the expression of the DNA repair enzyme MGMT and to chemosensitize glioma cells to temozolomide has been demonstrated. "
],
"offsets": [
[
636,
810
]
]
},
{
"id": "4480",
"type": "abstract",
"text": [
"In recent years, oncolytic viruses have been genetically engineered to target cancer cells selectively. "
],
"offsets": [
[
811,
915
]
]
},
{
"id": "4481",
"type": "abstract",
"text": [
"Oncolytic adenoviruses for the treatment of brain tumors. "
],
"offsets": [
[
916,
975
]
]
},
{
"id": "4482",
"type": "abstract",
"text": [
"Adenovirus is one such oncolytic virus that is being tested in clinical trials for the treatment of cancer. "
],
"offsets": [
[
976,
1084
]
]
}
] | [
{
"id": "4483",
"type": "Non-Specific_miRNAs",
"text": [
"microRNA"
],
"offsets": [
[
70,
78
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d97.s0.e0"
}
]
},
{
"id": "4484",
"type": "Non-Specific_miRNAs",
"text": [
"miRNA"
],
"offsets": [
[
80,
85
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d97.s0.e1"
}
]
},
{
"id": "4485",
"type": "Relation_Trigger",
"text": [
"modulate adenoviral protein expression"
],
"offsets": [
[
137,
175
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d97.s0.e2"
}
]
},
{
"id": "4486",
"type": "Diseases",
"text": [
"tumor"
],
"offsets": [
[
197,
202
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d97.s0.e3"
}
]
},
{
"id": "4487",
"type": "Non-Specific_miRNAs",
"text": [
"miRNA"
],
"offsets": [
[
465,
470
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d97.s2.e0"
}
]
},
{
"id": "4488",
"type": "Diseases",
"text": [
"tumor"
],
"offsets": [
[
507,
512
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d97.s2.e1"
}
]
},
{
"id": "4489",
"type": "Diseases",
"text": [
"cancer"
],
"offsets": [
[
299,
305
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d97.s2.e2"
}
]
},
{
"id": "4490",
"type": "Relation_Trigger",
"text": [
"inhibit the expression"
],
"offsets": [
[
683,
705
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d97.s3.e0"
}
]
},
{
"id": "4491",
"type": "Diseases",
"text": [
"glioma"
],
"offsets": [
[
758,
764
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d97.s3.e1"
}
]
},
{
"id": "4492",
"type": "Genes/Proteins",
"text": [
"MGMT"
],
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[
731,
735
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d97.s3.e2"
}
]
},
{
"id": "4493",
"type": "Relation_Trigger",
"text": [
"target"
],
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[
882,
888
]
],
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{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d97.s4.e0"
}
]
},
{
"id": "4494",
"type": "Diseases",
"text": [
"cancer"
],
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[
889,
895
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d97.s4.e1"
}
]
},
{
"id": "4495",
"type": "Diseases",
"text": [
"brain tumors"
],
"offsets": [
[
960,
972
]
],
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{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d97.s5.e0"
}
]
},
{
"id": "4496",
"type": "Diseases",
"text": [
"cancer"
],
"offsets": [
[
1076,
1082
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d97.s7.e0"
}
]
}
] | [] | [] | [
{
"id": "4497",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d97.s0.e0",
"arg2_id": "miRNA-corp.d97.s0.e3",
"normalized": []
},
{
"id": "4498",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d97.s0.e1",
"arg2_id": "miRNA-corp.d97.s0.e3",
"normalized": []
},
{
"id": "4499",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d97.s2.e0",
"arg2_id": "miRNA-corp.d97.s2.e1",
"normalized": []
},
{
"id": "4500",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d97.s2.e0",
"arg2_id": "miRNA-corp.d97.s2.e2",
"normalized": []
}
] |
4601 | miRNA-corp.d98 | [
{
"id": "4502",
"type": "title",
"text": [
"BACE1 mRNA levels tended to increase as miR-107 levels decreased in the progression of AD. Cell culture reporter assays performed with a subset of the predicted miR-107 binding sites indicate the presence of at least one physiological miR-107 miRNA recognition sequence in the 3'-UTR of BACE1 mRNA. "
],
"offsets": [
[
0,
299
]
]
},
{
"id": "4503",
"type": "abstract",
"text": [
"Computational analysis predicted that the 3'-untranslated region (UTR) of beta-site amyloid precursor protein-cleaving enzyme 1 (BACE1) mRNA is targeted multiply by miR-107. "
],
"offsets": [
[
300,
474
]
]
},
{
"id": "4504",
"type": "abstract",
"text": [
"From the same RNA material analyzed on miRNA microarrays, mRNA expression profiling was performed using Affymetrix Exon Array microarrays on nondemented, MCI, and AD patients. "
],
"offsets": [
[
475,
651
]
]
},
{
"id": "4505",
"type": "abstract",
"text": [
"Among the AD-related miRNA expression changes, miR-107 was exceptional because miR-107 levels decreased significantly even in patients with the earliest stages of pathology. "
],
"offsets": [
[
652,
826
]
]
},
{
"id": "4506",
"type": "abstract",
"text": [
"In situ hybridization with cross-comparison to neuropathology demonstrated that particular cerebral cortical laminas involved by AD pathology exhibit diminished neuronal miR-107 expression. "
],
"offsets": [
[
827,
1017
]
]
},
{
"id": "4507",
"type": "abstract",
"text": [
"We used miRNA expression microarrays on RNA extracted from human brain tissue from the University of Kentucky Alzheimer's Disease Center Brain Bank with near-optimal clinicopathological correlation. "
],
"offsets": [
[
1018,
1217
]
]
},
{
"id": "4508",
"type": "abstract",
"text": [
"Cases were separated into four groups: elderly nondemented with negligible AD-type pathology, nondemented with incipient AD pathology, mild cognitive impairment (MCI) with moderate AD pathology, and AD. "
],
"offsets": [
[
1218,
1421
]
]
},
{
"id": "4509",
"type": "abstract",
"text": [
"MicroRNAs (miRNAs) are small regulatory RNAs that participate in posttranscriptional gene regulation in a sequence-specific manner. "
],
"offsets": [
[
1422,
1554
]
]
},
{
"id": "4510",
"type": "abstract",
"text": [
"However, little is understood about the role(s) of miRNAs in Alzheimer's disease (AD). "
],
"offsets": [
[
1555,
1642
]
]
},
{
"id": "4511",
"type": "abstract",
"text": [
"Together, the coordinated application of miRNA profiling, Affymetrix microarrays, new bioinformatics predictions, in situ hybridization, and biochemical validation indicate that miR-107 may be involved in accelerated disease progression through regulation of BACE1. "
],
"offsets": [
[
1643,
1911
]
]
},
{
"id": "4512",
"type": "abstract",
"text": [
"The expression of microRNA miR-107 decreases early in Alzheimer's disease and may accelerate disease progression through regulation of beta-site amyloid precursor protein-cleaving enzyme 1. "
],
"offsets": [
[
1912,
2103
]
]
}
] | [
{
"id": "4513",
"type": "Specific_miRNAs",
"text": [
"miR-107"
],
"offsets": [
[
161,
168
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d98.s0.e0"
}
]
},
{
"id": "4514",
"type": "Specific_miRNAs",
"text": [
"miR-107"
],
"offsets": [
[
40,
47
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d98.s0.e1"
}
]
},
{
"id": "4515",
"type": "Specific_miRNAs",
"text": [
"miR-107"
],
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[
235,
242
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d98.s0.e2"
}
]
},
{
"id": "4516",
"type": "Genes/Proteins",
"text": [
"BACE1"
],
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[
287,
292
]
],
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{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d98.s0.e3"
}
]
},
{
"id": "4517",
"type": "Genes/Proteins",
"text": [
"BACE1"
],
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[
0,
5
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d98.s0.e4"
}
]
},
{
"id": "4518",
"type": "Diseases",
"text": [
"AD"
],
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[
87,
89
]
],
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{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d98.s0.e5"
}
]
},
{
"id": "4519",
"type": "Relation_Trigger",
"text": [
"levels tended to increase"
],
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[
11,
36
]
],
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{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d98.s0.e6"
}
]
},
{
"id": "4520",
"type": "Relation_Trigger",
"text": [
"levels decreased"
],
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[
48,
64
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d98.s0.e7"
}
]
},
{
"id": "4521",
"type": "Relation_Trigger",
"text": [
"binding sites"
],
"offsets": [
[
169,
182
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d98.s0.e8"
}
]
},
{
"id": "4522",
"type": "Non-Specific_miRNAs",
"text": [
"miRNA"
],
"offsets": [
[
243,
248
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d98.s0.e9"
}
]
},
{
"id": "4523",
"type": "Relation_Trigger",
"text": [
"miRNA recognition sequence in the 3'-UTR"
],
"offsets": [
[
243,
283
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d98.s0.e10"
}
]
},
{
"id": "4524",
"type": "Specific_miRNAs",
"text": [
"miR-107"
],
"offsets": [
[
465,
472
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d98.s1.e0"
}
]
},
{
"id": "4525",
"type": "Genes/Proteins",
"text": [
"BACE1"
],
"offsets": [
[
429,
434
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d98.s1.e1"
}
]
},
{
"id": "4526",
"type": "Genes/Proteins",
"text": [
"beta-site amyloid precursor protein-cleaving enzyme 1"
],
"offsets": [
[
374,
427
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d98.s1.e2"
}
]
},
{
"id": "4527",
"type": "Relation_Trigger",
"text": [
"3'-untranslated region (UTR) of beta-site amyloid precursor protein-cleaving enzyme 1 (BACE1) mRNA is targeted"
],
"offsets": [
[
342,
452
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d98.s1.e3"
}
]
},
{
"id": "4528",
"type": "Diseases",
"text": [
"AD"
],
"offsets": [
[
638,
640
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d98.s2.e0"
}
]
},
{
"id": "4529",
"type": "Non-Specific_miRNAs",
"text": [
"miRNA"
],
"offsets": [
[
514,
519
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d98.s2.e1"
}
]
},
{
"id": "4530",
"type": "Diseases",
"text": [
"MCI"
],
"offsets": [
[
629,
632
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d98.s2.e2"
}
]
},
{
"id": "4531",
"type": "Species",
"text": [
"patients"
],
"offsets": [
[
641,
649
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d98.s2.e3"
}
]
},
{
"id": "4532",
"type": "Specific_miRNAs",
"text": [
"miR-107"
],
"offsets": [
[
699,
706
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d98.s3.e0"
}
]
},
{
"id": "4533",
"type": "Specific_miRNAs",
"text": [
"miR-107"
],
"offsets": [
[
731,
738
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d98.s3.e1"
}
]
},
{
"id": "4534",
"type": "Non-Specific_miRNAs",
"text": [
"miRNA"
],
"offsets": [
[
673,
678
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d98.s3.e2"
}
]
},
{
"id": "4535",
"type": "Diseases",
"text": [
"AD"
],
"offsets": [
[
662,
664
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d98.s3.e3"
}
]
},
{
"id": "4536",
"type": "Relation_Trigger",
"text": [
"expression changes"
],
"offsets": [
[
679,
697
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d98.s3.e4"
}
]
},
{
"id": "4537",
"type": "Relation_Trigger",
"text": [
"levels decreased"
],
"offsets": [
[
739,
755
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d98.s3.e5"
}
]
},
{
"id": "4538",
"type": "Relation_Trigger",
"text": [
"decreased significantly"
],
"offsets": [
[
746,
769
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d98.s3.e6"
}
]
},
{
"id": "4539",
"type": "Species",
"text": [
"patients"
],
"offsets": [
[
778,
786
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d98.s3.e7"
}
]
},
{
"id": "4540",
"type": "Diseases",
"text": [
"AD"
],
"offsets": [
[
956,
958
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d98.s4.e0"
}
]
},
{
"id": "4541",
"type": "Specific_miRNAs",
"text": [
"miR-107"
],
"offsets": [
[
997,
1004
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d98.s4.e1"
}
]
},
{
"id": "4542",
"type": "Relation_Trigger",
"text": [
"diminished neuronal miR-107 expression"
],
"offsets": [
[
977,
1015
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d98.s4.e2"
}
]
},
{
"id": "4543",
"type": "Non-Specific_miRNAs",
"text": [
"miRNA"
],
"offsets": [
[
1026,
1031
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d98.s5.e0"
}
]
},
{
"id": "4544",
"type": "Diseases",
"text": [
"Alzheimer's Disease"
],
"offsets": [
[
1128,
1147
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d98.s5.e1"
}
]
},
{
"id": "4545",
"type": "Relation_Trigger",
"text": [
"correlation"
],
"offsets": [
[
1204,
1215
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d98.s5.e2"
}
]
},
{
"id": "4546",
"type": "Species",
"text": [
"human"
],
"offsets": [
[
1077,
1082
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d98.s5.e3"
}
]
},
{
"id": "4547",
"type": "Diseases",
"text": [
"AD"
],
"offsets": [
[
1339,
1341
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d98.s6.e0"
}
]
},
{
"id": "4548",
"type": "Diseases",
"text": [
"AD"
],
"offsets": [
[
1399,
1401
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d98.s6.e1"
}
]
},
{
"id": "4549",
"type": "Diseases",
"text": [
"AD"
],
"offsets": [
[
1417,
1419
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d98.s6.e2"
}
]
},
{
"id": "4550",
"type": "Diseases",
"text": [
"MCI"
],
"offsets": [
[
1380,
1383
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d98.s6.e3"
}
]
},
{
"id": "4551",
"type": "Diseases",
"text": [
"mild cognitive impairment"
],
"offsets": [
[
1353,
1378
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d98.s6.e4"
}
]
},
{
"id": "4552",
"type": "Diseases",
"text": [
"negligible AD"
],
"offsets": [
[
1282,
1295
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d98.s6.e5"
}
]
},
{
"id": "4553",
"type": "Non-Specific_miRNAs",
"text": [
"MicroRNAs"
],
"offsets": [
[
1422,
1431
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d98.s7.e0"
}
]
},
{
"id": "4554",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
"offsets": [
[
1433,
1439
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d98.s7.e1"
}
]
},
{
"id": "4555",
"type": "Relation_Trigger",
"text": [
"regulatory"
],
"offsets": [
[
1451,
1461
]
],
"normalized": [
{
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}
]
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{
"id": "4556",
"type": "Relation_Trigger",
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"regulation"
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1512,
1522
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{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d98.s7.e3"
}
]
},
{
"id": "4557",
"type": "Diseases",
"text": [
"Alzheimer's disease"
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1616,
1635
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{
"db_name": "miRNA-corpus",
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]
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{
"id": "4558",
"type": "Diseases",
"text": [
"AD"
],
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1637,
1639
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],
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{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d98.s8.e1"
}
]
},
{
"id": "4559",
"type": "Non-Specific_miRNAs",
"text": [
"miRNAs"
],
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[
1606,
1612
]
],
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{
"db_name": "miRNA-corpus",
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}
]
},
{
"id": "4560",
"type": "Specific_miRNAs",
"text": [
"miR-107"
],
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[
1821,
1828
]
],
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{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d98.s9.e0"
}
]
},
{
"id": "4561",
"type": "Genes/Proteins",
"text": [
"BACE1"
],
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[
1902,
1907
]
],
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{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d98.s9.e1"
}
]
},
{
"id": "4562",
"type": "Non-Specific_miRNAs",
"text": [
"miRNA"
],
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[
1684,
1689
]
],
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{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d98.s9.e2"
}
]
},
{
"id": "4563",
"type": "Relation_Trigger",
"text": [
"regulation"
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[
1888,
1898
]
],
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{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d98.s9.e3"
}
]
},
{
"id": "4564",
"type": "Relation_Trigger",
"text": [
"accelerated"
],
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[
1848,
1859
]
],
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{
"db_name": "miRNA-corpus",
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}
]
},
{
"id": "4565",
"type": "Specific_miRNAs",
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"miR-107"
],
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1939,
1946
]
],
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{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d98.s10.e0"
}
]
},
{
"id": "4566",
"type": "Diseases",
"text": [
"Alzheimer's disease"
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[
1966,
1985
]
],
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{
"db_name": "miRNA-corpus",
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}
]
},
{
"id": "4567",
"type": "Genes/Proteins",
"text": [
"beta-site amyloid precursor protein-cleaving enzyme 1"
],
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[
2047,
2100
]
],
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{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d98.s10.e2"
}
]
},
{
"id": "4568",
"type": "Non-Specific_miRNAs",
"text": [
"microRNA"
],
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[
1930,
1938
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d98.s10.e3"
}
]
},
{
"id": "4569",
"type": "Relation_Trigger",
"text": [
"expression of microRNA miR-107 decreases"
],
"offsets": [
[
1916,
1956
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d98.s10.e4"
}
]
},
{
"id": "4570",
"type": "Relation_Trigger",
"text": [
"regulation"
],
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[
2033,
2043
]
],
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{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d98.s10.e5"
}
]
},
{
"id": "4571",
"type": "Relation_Trigger",
"text": [
"accelerate"
],
"offsets": [
[
1994,
2004
]
],
"normalized": [
{
"db_name": "miRNA-corpus",
"db_id": "miRNA-corp.d98.s10.e6"
}
]
}
] | [] | [] | [
{
"id": "4572",
"type": "Specific_miRNAs-Genes/Proteins",
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"arg2_id": "miRNA-corp.d98.s0.e3",
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},
{
"id": "4573",
"type": "Specific_miRNAs-Genes/Proteins",
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},
{
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},
{
"id": "4575",
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},
{
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{
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},
{
"id": "4578",
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{
"id": "4579",
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{
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},
{
"id": "4581",
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},
{
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{
"id": "4583",
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},
{
"id": "4584",
"type": "Specific_miRNAs-Genes/Proteins",
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"arg2_id": "miRNA-corp.d98.s1.e1",
"normalized": []
},
{
"id": "4585",
"type": "Specific_miRNAs-Genes/Proteins",
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},
{
"id": "4586",
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"arg2_id": "miRNA-corp.d98.s2.e0",
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},
{
"id": "4587",
"type": "Non-Specific_miRNAs-Diseases",
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{
"id": "4588",
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},
{
"id": "4589",
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},
{
"id": "4590",
"type": "Specific_miRNAs-Diseases",
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},
{
"id": "4591",
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"arg2_id": "miRNA-corp.d98.s4.e0",
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},
{
"id": "4592",
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},
{
"id": "4593",
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},
{
"id": "4594",
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},
{
"id": "4595",
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},
{
"id": "4596",
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"arg1_id": "miRNA-corp.d98.s9.e2",
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},
{
"id": "4597",
"type": "Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d98.s10.e0",
"arg2_id": "miRNA-corp.d98.s10.e1",
"normalized": []
},
{
"id": "4598",
"type": "Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d98.s10.e0",
"arg2_id": "miRNA-corp.d98.s10.e2",
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},
{
"id": "4599",
"type": "Non-Specific_miRNAs-Diseases",
"arg1_id": "miRNA-corp.d98.s10.e3",
"arg2_id": "miRNA-corp.d98.s10.e1",
"normalized": []
},
{
"id": "4600",
"type": "Non-Specific_miRNAs-Genes/Proteins",
"arg1_id": "miRNA-corp.d98.s10.e3",
"arg2_id": "miRNA-corp.d98.s10.e2",
"normalized": []
}
] |
4643 | miRNA-corp.d99 | [
{
"id": "4602",
"type": "title",
"text": [
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],
"offsets": [
[
0,
120
]
]
},
{
"id": "4603",
"type": "abstract",
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[
121,
172
]
]
},
{
"id": "4604",
"type": "abstract",
"text": [
"Even though all diagnostic procedures were made on time and that adequate antifungal and supportive agents were applied very early after the infection onset, the outcome was fatal. "
],
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173,
354
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]
},
{
"id": "4605",
"type": "abstract",
"text": [
"Because of infective diathesis in patients with SLE, which present with common and opportunistic infections, and due to high mortality rates caused by these infections, we have tried to emphasise the importance of taking adequate specimens early after infection outcome for these rare infective agents like C. neophormans. "
],
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355,
678
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]
},
{
"id": "4606",
"type": "abstract",
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],
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679,
722
]
]
},
{
"id": "4607",
"type": "abstract",
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],
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[
723,
835
]
]
},
{
"id": "4608",
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"[Cryptococcal meningitis as a diagnostic problem in a patient with SLE--case report]. "
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836,
923
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]
},
{
"id": "4609",
"type": "abstract",
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],
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[
924,
989
]
]
},
{
"id": "4610",
"type": "abstract",
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],
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990,
1090
]
]
},
{
"id": "4611",
"type": "abstract",
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],
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[
1091,
1331
]
]
},
{
"id": "4612",
"type": "abstract",
"text": [
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],
"offsets": [
[
1332,
1506
]
]
},
{
"id": "4613",
"type": "abstract",
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],
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[
1507,
1663
]
]
},
{
"id": "4614",
"type": "abstract",
"text": [
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],
"offsets": [
[
1664,
1853
]
]
}
] | [
{
"id": "4615",
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19,
36
]
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167,
170
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314,
323
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},
{
"id": "4618",
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438,
462
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]
},
{
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512,
522
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},
{
"id": "4620",
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607,
616
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{
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403,
406
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}
]
},
{
"id": "4622",
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389,
397
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}
]
},
{
"id": "4623",
"type": "Diseases",
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686,
696
]
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}
]
},
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"id": "4624",
"type": "Diseases",
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723,
751
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}
]
},
{
"id": "4625",
"type": "Diseases",
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"SLE"
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753,
756
]
],
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]
},
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"id": "4626",
"type": "Diseases",
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],
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903,
906
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},
{
"id": "4627",
"type": "Diseases",
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],
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837,
860
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],
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]
},
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"id": "4628",
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897
]
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}
]
},
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978,
987
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]
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974
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965
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]
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1078
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}
]
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1034
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},
{
"id": "4634",
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1262,
1272
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}
]
},
{
"id": "4635",
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1322,
1328
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},
{
"id": "4636",
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1299,
1317
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1217
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] | [] | [] | [] |