bigbio/gad · Datasets at Hugging Face

id stringlengths 1 4	document_id stringlengths 1 4	text stringlengths 42 538	labels list
1400	1400	The data from the current study show that the @GENE$ gene has several low-frequency missense polymorphisms and that the codon 139 polymorphism is an independent risk factor for orolaryngeal @DISEASE$ in blacks.	[ "0" ]
1401	1401	Follow-up of @GENE$ demonstrated that these polymorphisms have little effect after 8 years, because the subset of SP who had @DISEASE$ after study entry had the same genotype distribution as the global population of SP, suggesting that factors other than CCR5 or CCR2 genetic variants must be responsible for the long-term maintenance of nonprogression.	[ "0" ]
1402	1402	Our findings support an association of @DISEASE$ with an @GENE$ functional polymorphism and reveal that this association is stronger in the absence of PTPN22 risk genotypes.	[ "0" ]
1403	1403	The @GENE$ T variant does not appear to be associated with risk of @DISEASE$ in Australian women.	[ "1" ]
1404	1404	Mutations and polymorphisms of ngn3 gene are not significantly associated with @GENE$ II (@DISEASE$ in the Japanese subjects.	[ "0" ]
1405	1405	We suggest that this polymorphism and others at the @GENE$) locus be further studied in relation to @DISEASE$.	[ "1" ]
1406	1406	In conclusion, the M196R (676 T-->G) variant in exon 6 of @GENE$ is associated with @DISEASE$ and PCOS, further suggesting a role for inflammatory cytokines in the pathogenesis of these disorders.	[ "0" ]
1407	1407	Thus, Gly15Gly polymorphism of @GENE$ gene might play a role in @DISEASE$ in type 2 diabetic patients.	[ "0" ]
1408	1408	The polymorphisms of ADH2, ALDH2, and CYP2E1 were significantly different in Korean patients with alcoholism and Korean control subjects without @DISEASE$, but ADH3 and @GENE$ did not differ between the two groups.	[ "1" ]
1409	1409	Our findings indicate that the @GENE$ receptor alpha gene does not exert a substantial influence on the inheritance of @DISEASE$ or asthma in this Japanese population.	[ "0" ]
1410	1410	Our results do suggest that variants of the @GENE$ gene might be involved in the determination of @DISEASE$.	[ "1" ]
1411	1411	The common @GENE$ 2992T allele, in the mother or offspring or both, may confer reduced fetal growth restraint, as indicated by associations with larger offspring birth size, higher cord @DISEASE$ IGF-II levels, and lower compensatory early postnatal catch-up weight gain, that are more evident among mother's smaller first-born infants.	[ "0" ]
1412	1412	Observations from this study confirm earlier findings of a negative association between DRB113 and cervical cancer and suggest that specific @GENE$-DQB1 haplotype combinations, rather than individual DQB103 alleles, increase the risk for @DISEASE$.	[ "1" ]
1413	1413	Interestingly, all patients harboring @GENE$ mutations had a severe yet progressive @DISEASE$ with severe macular atrophy but no or mild hyperopia.	[ "0" ]
1414	1414	C-->T polymorphism of @GENE$ gene was considered as one of the possible susceptible genes, which specifically increased the risk of tobacco-related but CagA negative types of intestinal stomach cancer and stomach cardia @DISEASE$.	[ "0" ]
1415	1415	Our results suggest that @DISEASE$ of the @GENE$ gene is unlikely to play an important role in the mechanism of resistance to paclitaxel in breast cancer.	[ "0" ]
1416	1416	Herein, the C -159T promoter polymorphism of the @GENE$ gene was associated in female but not in male patients with @DISEASE$.	[ "1" ]
1417	1417	Isoflavone supplementation, when provided in the form and dose used in this study, had no effect on lipid or other metabolic biomarkers of @DISEASE$ risk in postmenopausal women but may increase @GENE$ cholesterol in an estrogen receptor beta gene-polymorphic subgroup.	[ "0" ]
1418	1418	This study does not support an involvement of the coding region of the @GENE$ gene in the @DISEASE$ of diabetic nephropathy in type 1 diabetic patients.	[ "0" ]
1419	1419	When numeric scores were assigned to both the SNP and demographic data, and sequentially combined by a @GENE$ algorithm in a risk model, the composite score was found to be linearly related to @DISEASE$ risk with a bimodal distribution.	[ "0" ]
1420	1420	@GENE$ functional mutations or polymorphisms are not associated with the intrinsic mechanism of GDPP in girls with and without EEG @DISEASE$.	[ "0" ]
1421	1421	@GENE$ gene polymorphism is probably an influence factor on the genetic susceptibility of @DISEASE$ infection.	[ "1" ]
1422	1422	Under our conditions, our study does not confirm any relationship between the polymorphic CAG repeat in the @GENE$ gene and @DISEASE$.	[ "1" ]
1423	1423	We conclude that no association exists between genetic variation at the @GENE$ locus and alcoholism in Chinese Han, Atayal, and @DISEASE$ males.	[ "0" ]
1424	1424	We speculate that the genetic polymorphism producing the proline(7) substitution of @GENE$ might not predispose to alcoholism, but indeed retard the @DISEASE$ to alcoholism.	[ "0" ]
1425	1425	The 105A/C polymorphism of the @GENE$ gene may be associated with the pathogenesis of @DISEASE$.	[ "1" ]
1426	1426	These results suggested that the variations at the NT3 and the @GENE$ genes do not influence the @DISEASE$ risk, but a role in the susceptibility of subgroups of the patients cannot be excluded.	[ "1" ]
1427	1427	The G894T @DISEASE$ of the @GENE$ gene may be a marker for genetical predisposition of CHD in Chinese Han population.	[ "0" ]
1428	1428	The high expression level of @GENE$ in HCC, especially in @DISEASE$ with metastasis, suggests that the over-expression of hTcf-4 gene may be closely associated with development and progression of HCC, but the mutation of this gene seemed to play less important role in this respect.	[ "0" ]
1429	1429	A allele in G341A (Ser88Asn) polymorphism may be a genetic risk factor of @GENE$ among Changsha Hans, especially the CH patients with @DISEASE$ and those with a family history of hypertension.	[ "0" ]
1430	1430	@GENE$ and FASLG polymorphisms appear to jointly contribute to risk of @DISEASE$ in this southern Chinese population.	[ "1" ]
1431	1431	In conclusion, our data do not support the strong positive associations of @GENE$ promoter polymorphisms with @DISEASE$ reported in previous smaller studies.	[ "1" ]
1432	1432	Our results significantly support @GENE$ as a susceptibility locus for schizophrenia and offer some support for the implication of both RGS4 and DISC1 in the etiology of @DISEASE$.	[ "1" ]
1433	1433	The @GENE$-232C > G polymorphism is not a major contributor to the @DISEASE$ of Type 2 diabetes in the Danish population.	[ "0" ]
1434	1434	On the basis of the results, no significant association is found for the MMP-1 polymorphisms with susceptibility of periodontitis, while the @GENE$ gene polymorphism may contribute to periodontal tissue destruction during @DISEASE$ in Brazilian subjects.	[ "1" ]
1435	1435	Our findings are consistent with a lack of involvement of @GENE$ rs2235371 and rs642961 polymorphisms in the NSCL/P @DISEASE$ in the Brazilian population.	[ "0" ]
1436	1436	These findings indicated that the polymorphism of @GENE$ but not TLR4 Asp299Gly @DISEASE$ was associated with Chinese patients with colorectal cancer, and the CD14 gene may contribute to the predisposition to colorectal cancer.	[ "0" ]
1437	1437	we confirmed the effect of the @GENE$-promoter polymorphism on gene expression, but our data did not support a significant effect of this functional variation on @DISEASE$ risk.	[ "1" ]
1438	1438	the G191R variant of @GENE$ mitigates intrapancreatic trypsin activity and thereby protects against @DISEASE$.	[ "1" ]
1439	1439	The insertion of the guanine in the promoter of the @GENE$ gene does not appear to increase the risk of development of @DISEASE$, preeclampsia and eclampsia.	[ "1" ]
1440	1440	we could not find evidence of association between RGS4, @GENE$, COMT and GRK3 genes and @DISEASE$ 1 in the Scottish population.	[ "1" ]
1441	1441	These results suggest that either the @DISEASE$ or non-deletion of the @GENE$ gene shows no significant effect on smoking behavior for the Japanese population examined.	[ "0" ]
1442	1442	Our data do not demonstrate a significant influence of this locus on @DISEASE$ risk, but we cannot exclude a @GENE$ influence or an influence confined to subgroups.	[ "0" ]
1443	1443	Our findings suggest that the G/G genotype of the @GENE$ polymorphism is associated with worse OS among early-stage @DISEASE$ patients, particularly those with squamous cell histology.	[ "0" ]
1444	1444	@GENE$ seems to be a very strong candidate for explaining some of the pathophysiological pathways leading to the development of both @DISEASE$ and high myopia.	[ "0" ]
1445	1445	Our results point out that GG genotype of @GENE$ might be a genetic risk factor for the expression of cardiac @DISEASE$ phenotype in the patients with hypertrophic cardiomyopathy.	[ "0" ]
1446	1446	Our results confirm that recessive D90A @DISEASE$ is present in Italy and it is associated with the phenotype already described A screening for that mutation, easily made by RFLP, should be made in sporadic @GENE$ patients, especially where clinical investigation indicates its presence.	[ "0" ]
1447	1447	Our results further implicate the @GENE$ gene in the development of @DISEASE$.	[ "1" ]
1448	1448	No statistical significance was found for these @DISEASE$ patients after comparison with normal controls (4.0%) for the allelic frequencies of @GENE$2 and SULT1A22.	[ "0" ]
1449	1449	In conclusion, our data do not support a role of the @GENE$ genotype as a prognostic marker in @DISEASE$.	[ "0" ]
1450	1450	The @GENE$ Gly146Ala variation may constitute a susceptible factor for development of @DISEASE$ and impairment of insulin actions.	[ "0" ]
1451	1451	our results do not support a major role for the (@GENE$)n dinucleotide repeat in @DISEASE$ susceptibility in Han Chinese.	[ "0" ]
1452	1452	In conclusion, our data do not suggest evidence for a major role of the respective SNPs in @GENE$ in the @DISEASE$ of extreme obesity in our study groups.	[ "0" ]
1453	1453	We conclude that @GENE$ Arg38Gln polymorphism is not likely to play a major role in the pathogenesis of @DISEASE$ in Chinese populations.	[ "1" ]
1454	1454	We conclude that the described @GENE$ polymorphisms are not associated with IDDM susceptibility and DMB genotyping is unlikely to improve the assessment of genetic risk for @DISEASE$.	[ "1" ]
1455	1455	The de novo origin of an @GENE$ (Arg677ter) @DISEASE$ in a patient with simplex RP suggests that this common autosomal dominant RP mutation can arise independently in the population and supports the hypothesis of a mutational hotspot in the RP1 gene.	[ "0" ]
1456	1456	alterations in gene copy number of PGRN and @GENE$ are not a cause of disease in this collection of @DISEASE$ patients.	[ "1" ]
1457	1457	Our results provide no evidence for genetic association conferred by the -384 and 114 @GENE$ SNP with respect to susceptibility and severity of @DISEASE$.	[ "1" ]
1458	1458	Our results indicate that common variants in the @GENE$, CHEK2 or ERBB2 genes are not involved in modifying @DISEASE$ survival or the risk of tumour-characteristic-defined breast cancer.	[ "1" ]
1459	1459	Our results suggest that genetic variations in @GENE$ or nearby genes could confer risks associated with @DISEASE$ in Japanese individuals.	[ "1" ]
1460	1460	Our results suggest that @GENE$ might be an important susceptibility gene involved in the @DISEASE$ of childhood absence epilepsy.	[ "0" ]
1461	1461	@GENE$ gene 3020insC @DISEASE$ is not a major contributor to the susceptibility to both Crohn's disease and ulcerative colitis in Chinese Han patients.	[ "0" ]
1462	1462	The study showed a positive association between @DISEASE$ and the @GENE$ gene, suggesting that HTR2A plays an important role in the pathogenesis of panic disorder.	[ "1" ]
1463	1463	The @GENE$ gene polymorphisms were found to play a role in the development of @DISEASE$, especially MI, in patients with CP infection.	[ "1" ]
1464	1464	@GENE$+1267 genotype is a stronger predictor of @DISEASE$ in patients with community-acquired pneumonia than lymphotoxin-alpha +250 genotype.	[ "0" ]
1465	1465	Our results suggest that @GENE$ genotypic @DISEASE$ does not associate with susceptibility to thoracic empyema in humans.	[ "0" ]
1466	1466	The present study fails to demonstrate that the genetic polymorphisms of @GENE$-VNTR and TPH-A218C affect the antidepressant effect of fluvoxamine in Japanese patients with @DISEASE$.	[ "1" ]
1467	1467	This variant strongly associates with @DISEASE$ and, in subjects with the Trp64Arg @GENE$ variant, an increased BMI, suggesting an interaction between these two common gene variants.	[ "1" ]
1468	1468	The @GENE$ genotype of HMOX1 reduced the incidence of @DISEASE$, possibly due to the high expression level of HMOX1.	[ "0" ]
1469	1469	These data could partly explain the abnormal secretion of @GENE$ occurring in schizophrenic patients in response to infections or different stressors and suggest a potential role of IL-10 as a candidate gene for susceptibility to @DISEASE$.	[ "1" ]
1470	1470	Polymorphism of the @GENE$ or another gene in its vicinity appears to contribute to the etiology of @DISEASE$ for the subgroups of DR4- and DR5-positive Italians and Russians.	[ "1" ]
1471	1471	In conclusion, a case-control study was used to analyze, for the first time, the influence of @GENE$ and TLR4 gene polymorphism on the predisposition and clinical characteristics of @DISEASE$ and RA but provided no evidence for association of TLR2 or TLR4 gene polymorphism with either disease in the population under study.	[ "1" ]
1472	1472	These results indicate that exon 3 of the human @GENE$ gene lacks association with @DISEASE$ in Japanese patients.	[ "1" ]
1473	1473	Homozygosity for the @GENE$ 1186C variant is a weak risk factor for @DISEASE$ especially in older women.	[ "1" ]
1474	1474	There is a subgroup of @DISEASE$ which develop via the MSI pathway that carry an alteration of the @GENE$ gene.	[ "0" ]
1475	1475	The @GENE$ BstUI RFLP is associated with ATP and more specifically, chronic Achilles @DISEASE$.	[ "0" ]
1476	1476	In our population DD @GENE$ genotype is associated with @DISEASE$ in young patients, although smoking, family history and hypercholesterolemia show a more powerful association.	[ "1" ]
1477	1477	An increased susceptibility associated to the -169 T allele was found when MS patients and controls were compared, supporting the role of the @GENE$ locus in @DISEASE$ predisposition and therefore extending the evidence of its general influence on autoimmunity.	[ "1" ]
1478	1478	Thus, neither HLA DMA nor DMB was associated with @DISEASE$ in this population, and not all shared-epitope-bearing haplotypes had the same @GENE$ allele distribution.	[ "1" ]
1479	1479	The presence of the inhibitory allele @GENE$ in combination with the HLA-B*57s alleles that contain the Bw4-I80 epitope, has a highly protective effect against @DISEASE$ to AIDS in Zambian patients.	[ "0" ]
1480	1480	These results indicate an association of the @GENE$ intron 4 variants and/or its flanking loci with mechanisms that may enhance @DISEASE$ susceptibility, especially to squamous cell carcinoma of the lung.	[ "1" ]
1481	1481	Our results suggest that the @GENE$ functional polymorphisms analyzed do not seem to be implicated in genetic susceptibility to @DISEASE$.	[ "1" ]
1482	1482	There are ethnic differences in the @GENE$ polymorphisms, and the polymorphisms are strongly associated with @DISEASE$.	[ "1" ]
1483	1483	We found that XPA A23G and XPC Lys939Gln polymorphisms may be risk factors for @DISEASE$ and evidence that positive interactions between the polymorphisms in XPA/@GENE$ and XPC/XPD may occur.	[ "0" ]
1484	1484	As its homologue @GENE$, CAPN5 seems to influence traits related to increased risk for @DISEASE$.	[ "0" ]
1485	1485	Genetic linkage of @GENE$ and UGT1A9 polymorphisms to UGT1A1*6, related to reduced catalytic and transcriptional activities of UGTs, is associated with the decreased glucuronosyltransferase activity for SN-38 in Japanese patients with @DISEASE$.	[ "0" ]
1486	1486	These results suggest that the @GENE$, RUNX1, and SUMO4 polymorphisms analyzed do not confer a relevant role in susceptibility to @DISEASE$ in the Spanish population.	[ "1" ]
1487	1487	These data suggest that although there are marked ethnic differences in their distribution, the common genetic polymorphisms of the human @GENE$-adrenergic receptor gene do not cosegregate with the presence of @DISEASE$ in either black or white Americans.	[ "0" ]
1488	1488	These results reveal that the @GENE$ gene polymorphism is associated with an increased risk of gastric atrophy induced by @DISEASE$ and might predispose to gastric cancer.	[ "0" ]
1489	1489	The @GENE$ gene is significantly associated with @DISEASE$ susceptibility, suggesting the possibility that PD-1 may contribute to the pathogenesis of RA.	[ "1" ]
1490	1490	the PS1 intronic polymorphism did not modify the risk for sporadic @DISEASE$, neither independently nor synergistically with the APOE epsilon4 allele or @GENE$ A allele, in Koreans.	[ "0" ]
1491	1491	(1) @GENE$ * 0405 and DRB1 * 15 are closely associated with the susceptibility to VKH syndrome, DRB1 * 0405 may be the major susceptible gene and DRB1 * 15 may be the @DISEASE$; (2) DRB1 * 14 and DRB1 * 08 are negatively associated with the susceptibility to VKH syndrome, suggesting that they may be the resistant genes; (3) DRB1 * 0405 is not related to the clinical features, incidence of ocular complications as well as visual prognosis.	[ "0" ]
1492	1492	These results suggest that the @GENE$ gene together with the aldose reductase gene are associated with susceptibility to DN in patients with @DISEASE$.	[ "0" ]
1493	1493	Identification of @GENE$ mutations in 12.2% of patients with adult alcoholic and @DISEASE$ suggests an important role for SPINK1 as a predisposing factor in adult chronic pancreatitis.	[ "0" ]
1494	1494	The @GENE$ genotype was not a significant or clinically relevant risk factor in the development of serious NSAID-related @DISEASE$ in this group of subjects.	[ "0" ]
1495	1495	We conclude that the analyzed SNPs in @GENE$ and GALR1 do not play a major role in early onset @DISEASE$ or dietary fat intake in the obese children and adolescents of our study groups.	[ "1" ]
1496	1496	These analyses suggest that variants of @GENE$ are not associated with risk of @DISEASE$.	[ "1" ]
1497	1497	This study is the first to report an association between the @GENE$ gene and @DISEASE$.	[ "1" ]
1498	1498	Observations from this study confirm earlier findings of a negative association between @GENE$13 and @DISEASE$ and suggest that specific DRB1-DQB1 haplotype combinations, rather than individual DQB103 alleles, increase the risk for cervical cancer.	[ "1" ]
1499	1499	We conclude that the human @GENE$ gene is rather involved in the development of @DISEASE$ and changes in total IgE levels than contributing to the pathogenesis of asthma.	[ "1" ]

1400

The data from the current study show that the @GENE$ gene has several low-frequency missense polymorphisms and that the codon 139 polymorphism is an independent risk factor for orolaryngeal @DISEASE$ in blacks.

[ "0" ]

1401

Follow-up of @GENE$ demonstrated that these polymorphisms have little effect after 8 years, because the subset of SP who had @DISEASE$ after study entry had the same genotype distribution as the global population of SP, suggesting that factors other than CCR5 or CCR2 genetic variants must be responsible for the long-term maintenance of nonprogression.

[ "0" ]

1402

Our findings support an association of @DISEASE$ with an @GENE$ functional polymorphism and reveal that this association is stronger in the absence of PTPN22 risk genotypes.

[ "0" ]

1403

The @GENE$ T variant does not appear to be associated with risk of @DISEASE$ in Australian women.

[ "1" ]

1404

Mutations and polymorphisms of ngn3 gene are not significantly associated with @GENE$ II (@DISEASE$ in the Japanese subjects.

[ "0" ]

1405

We suggest that this polymorphism and others at the @GENE$) locus be further studied in relation to @DISEASE$.

[ "1" ]

1406

In conclusion, the M196R (676 T-->G) variant in exon 6 of @GENE$ is associated with @DISEASE$ and PCOS, further suggesting a role for inflammatory cytokines in the pathogenesis of these disorders.

[ "0" ]

1407

Thus, Gly15Gly polymorphism of @GENE$ gene might play a role in @DISEASE$ in type 2 diabetic patients.

[ "0" ]

1408

The polymorphisms of ADH2, ALDH2, and CYP2E1 were significantly different in Korean patients with alcoholism and Korean control subjects without @DISEASE$, but ADH3 and @GENE$ did not differ between the two groups.

[ "1" ]

1409

Our findings indicate that the @GENE$ receptor alpha gene does not exert a substantial influence on the inheritance of @DISEASE$ or asthma in this Japanese population.

[ "0" ]

1410

Our results do suggest that variants of the @GENE$ gene might be involved in the determination of @DISEASE$.

[ "1" ]

1411

The common @GENE$ 2992T allele, in the mother or offspring or both, may confer reduced fetal growth restraint, as indicated by associations with larger offspring birth size, higher cord @DISEASE$ IGF-II levels, and lower compensatory early postnatal catch-up weight gain, that are more evident among mother's smaller first-born infants.

[ "0" ]

1412

Observations from this study confirm earlier findings of a negative association between DRB1*13 and cervical cancer and suggest that specific @GENE$-DQB1 haplotype combinations, rather than individual DQB1*03 alleles, increase the risk for @DISEASE$.

[ "1" ]

1413

Interestingly, all patients harboring @GENE$ mutations had a severe yet progressive @DISEASE$ with severe macular atrophy but no or mild hyperopia.

[ "0" ]

1414

C-->T polymorphism of @GENE$ gene was considered as one of the possible susceptible genes, which specifically increased the risk of tobacco-related but CagA negative types of intestinal stomach cancer and stomach cardia @DISEASE$.

[ "0" ]

1415

Our results suggest that @DISEASE$ of the @GENE$ gene is unlikely to play an important role in the mechanism of resistance to paclitaxel in breast cancer.

[ "0" ]

1416

Herein, the C -159T promoter polymorphism of the @GENE$ gene was associated in female but not in male patients with @DISEASE$.

[ "1" ]

1417

Isoflavone supplementation, when provided in the form and dose used in this study, had no effect on lipid or other metabolic biomarkers of @DISEASE$ risk in postmenopausal women but may increase @GENE$ cholesterol in an estrogen receptor beta gene-polymorphic subgroup.

[ "0" ]

1418

This study does not support an involvement of the coding region of the @GENE$ gene in the @DISEASE$ of diabetic nephropathy in type 1 diabetic patients.

[ "0" ]

1419

When numeric scores were assigned to both the SNP and demographic data, and sequentially combined by a @GENE$ algorithm in a risk model, the composite score was found to be linearly related to @DISEASE$ risk with a bimodal distribution.

[ "0" ]

1420

@GENE$ functional mutations or polymorphisms are not associated with the intrinsic mechanism of GDPP in girls with and without EEG @DISEASE$.

[ "0" ]

1421

@GENE$ gene polymorphism is probably an influence factor on the genetic susceptibility of @DISEASE$ infection.

[ "1" ]

1422

Under our conditions, our study does not confirm any relationship between the polymorphic CAG repeat in the @GENE$ gene and @DISEASE$.

[ "1" ]

1423

We conclude that no association exists between genetic variation at the @GENE$ locus and alcoholism in Chinese Han, Atayal, and @DISEASE$ males.

[ "0" ]

1424

We speculate that the genetic polymorphism producing the proline(7) substitution of @GENE$ might not predispose to alcoholism, but indeed retard the @DISEASE$ to alcoholism.

[ "0" ]

1425

The 105A/C polymorphism of the @GENE$ gene may be associated with the pathogenesis of @DISEASE$.

[ "1" ]

1426

These results suggested that the variations at the NT3 and the @GENE$ genes do not influence the @DISEASE$ risk, but a role in the susceptibility of subgroups of the patients cannot be excluded.

[ "1" ]

1427

The G894T @DISEASE$ of the @GENE$ gene may be a marker for genetical predisposition of CHD in Chinese Han population.

[ "0" ]

1428

The high expression level of @GENE$ in HCC, especially in @DISEASE$ with metastasis, suggests that the over-expression of hTcf-4 gene may be closely associated with development and progression of HCC, but the mutation of this gene seemed to play less important role in this respect.

[ "0" ]

1429

A allele in G341A (Ser88Asn) polymorphism may be a genetic risk factor of @GENE$ among Changsha Hans, especially the CH patients with @DISEASE$ and those with a family history of hypertension.

[ "0" ]

1430

@GENE$ and FASLG polymorphisms appear to jointly contribute to risk of @DISEASE$ in this southern Chinese population.

[ "1" ]

1431

In conclusion, our data do not support the strong positive associations of @GENE$ promoter polymorphisms with @DISEASE$ reported in previous smaller studies.

[ "1" ]

1432

Our results significantly support @GENE$ as a susceptibility locus for schizophrenia and offer some support for the implication of both RGS4 and DISC1 in the etiology of @DISEASE$.

[ "1" ]

1433

The @GENE$-232C > G polymorphism is not a major contributor to the @DISEASE$ of Type 2 diabetes in the Danish population.

[ "0" ]

1434

On the basis of the results, no significant association is found for the MMP-1 polymorphisms with susceptibility of periodontitis, while the @GENE$ gene polymorphism may contribute to periodontal tissue destruction during @DISEASE$ in Brazilian subjects.

[ "1" ]

1435

Our findings are consistent with a lack of involvement of @GENE$ rs2235371 and rs642961 polymorphisms in the NSCL/P @DISEASE$ in the Brazilian population.

[ "0" ]

1436

These findings indicated that the polymorphism of @GENE$ but not TLR4 Asp299Gly @DISEASE$ was associated with Chinese patients with colorectal cancer, and the CD14 gene may contribute to the predisposition to colorectal cancer.

[ "0" ]

1437

we confirmed the effect of the @GENE$-promoter polymorphism on gene expression, but our data did not support a significant effect of this functional variation on @DISEASE$ risk.

[ "1" ]

1438

the G191R variant of @GENE$ mitigates intrapancreatic trypsin activity and thereby protects against @DISEASE$.

[ "1" ]

1439

The insertion of the guanine in the promoter of the @GENE$ gene does not appear to increase the risk of development of @DISEASE$, preeclampsia and eclampsia.

[ "1" ]

1440

we could not find evidence of association between RGS4, @GENE$, COMT and GRK3 genes and @DISEASE$ 1 in the Scottish population.

[ "1" ]

1441

These results suggest that either the @DISEASE$ or non-deletion of the @GENE$ gene shows no significant effect on smoking behavior for the Japanese population examined.

[ "0" ]

1442

Our data do not demonstrate a significant influence of this locus on @DISEASE$ risk, but we cannot exclude a @GENE$ influence or an influence confined to subgroups.

[ "0" ]

1443

Our findings suggest that the G/G genotype of the @GENE$ polymorphism is associated with worse OS among early-stage @DISEASE$ patients, particularly those with squamous cell histology.

[ "0" ]

1444

@GENE$ seems to be a very strong candidate for explaining some of the pathophysiological pathways leading to the development of both @DISEASE$ and high myopia.

[ "0" ]

1445

Our results point out that GG genotype of @GENE$ might be a genetic risk factor for the expression of cardiac @DISEASE$ phenotype in the patients with hypertrophic cardiomyopathy.

[ "0" ]

1446

Our results confirm that recessive D90A @DISEASE$ is present in Italy and it is associated with the phenotype already described A screening for that mutation, easily made by RFLP, should be made in sporadic @GENE$ patients, especially where clinical investigation indicates its presence.

[ "0" ]

1447

Our results further implicate the @GENE$ gene in the development of @DISEASE$.

[ "1" ]

1448

No statistical significance was found for these @DISEASE$ patients after comparison with normal controls (4.0%) for the allelic frequencies of @GENE$*2 and SULT1A2*2.

[ "0" ]

1449

In conclusion, our data do not support a role of the @GENE$ genotype as a prognostic marker in @DISEASE$.

[ "0" ]

1450

The @GENE$ Gly146Ala variation may constitute a susceptible factor for development of @DISEASE$ and impairment of insulin actions.

[ "0" ]

1451

our results do not support a major role for the (@GENE$)n dinucleotide repeat in @DISEASE$ susceptibility in Han Chinese.

[ "0" ]

1452

In conclusion, our data do not suggest evidence for a major role of the respective SNPs in @GENE$ in the @DISEASE$ of extreme obesity in our study groups.

[ "0" ]

1453

We conclude that @GENE$ Arg38Gln polymorphism is not likely to play a major role in the pathogenesis of @DISEASE$ in Chinese populations.

[ "1" ]

1454

We conclude that the described @GENE$ polymorphisms are not associated with IDDM susceptibility and DMB genotyping is unlikely to improve the assessment of genetic risk for @DISEASE$.

[ "1" ]

1455

The de novo origin of an @GENE$ (Arg677ter) @DISEASE$ in a patient with simplex RP suggests that this common autosomal dominant RP mutation can arise independently in the population and supports the hypothesis of a mutational hotspot in the RP1 gene.

[ "0" ]

1456

alterations in gene copy number of PGRN and @GENE$ are not a cause of disease in this collection of @DISEASE$ patients.

[ "1" ]

1457

Our results provide no evidence for genetic association conferred by the -384 and 114 @GENE$ SNP with respect to susceptibility and severity of @DISEASE$.

[ "1" ]

1458

Our results indicate that common variants in the @GENE$, CHEK2 or ERBB2 genes are not involved in modifying @DISEASE$ survival or the risk of tumour-characteristic-defined breast cancer.

[ "1" ]

1459

Our results suggest that genetic variations in @GENE$ or nearby genes could confer risks associated with @DISEASE$ in Japanese individuals.

[ "1" ]

1460

Our results suggest that @GENE$ might be an important susceptibility gene involved in the @DISEASE$ of childhood absence epilepsy.

[ "0" ]

1461

@GENE$ gene 3020insC @DISEASE$ is not a major contributor to the susceptibility to both Crohn's disease and ulcerative colitis in Chinese Han patients.

[ "0" ]

1462

The study showed a positive association between @DISEASE$ and the @GENE$ gene, suggesting that HTR2A plays an important role in the pathogenesis of panic disorder.

[ "1" ]

1463

The @GENE$ gene polymorphisms were found to play a role in the development of @DISEASE$, especially MI, in patients with CP infection.

[ "1" ]

1464

@GENE$+1267 genotype is a stronger predictor of @DISEASE$ in patients with community-acquired pneumonia than lymphotoxin-alpha +250 genotype.

[ "0" ]

1465

Our results suggest that @GENE$ genotypic @DISEASE$ does not associate with susceptibility to thoracic empyema in humans.

[ "0" ]

1466

The present study fails to demonstrate that the genetic polymorphisms of @GENE$-VNTR and TPH-A218C affect the antidepressant effect of fluvoxamine in Japanese patients with @DISEASE$.

[ "1" ]

1467

This variant strongly associates with @DISEASE$ and, in subjects with the Trp64Arg @GENE$ variant, an increased BMI, suggesting an interaction between these two common gene variants.

[ "1" ]

1468

The @GENE$ genotype of HMOX1 reduced the incidence of @DISEASE$, possibly due to the high expression level of HMOX1.

[ "0" ]

1469

These data could partly explain the abnormal secretion of @GENE$ occurring in schizophrenic patients in response to infections or different stressors and suggest a potential role of IL-10 as a candidate gene for susceptibility to @DISEASE$.

[ "1" ]

1470

Polymorphism of the @GENE$ or another gene in its vicinity appears to contribute to the etiology of @DISEASE$ for the subgroups of DR4- and DR5-positive Italians and Russians.

[ "1" ]

1471

In conclusion, a case-control study was used to analyze, for the first time, the influence of @GENE$ and TLR4 gene polymorphism on the predisposition and clinical characteristics of @DISEASE$ and RA but provided no evidence for association of TLR2 or TLR4 gene polymorphism with either disease in the population under study.

[ "1" ]

1472

These results indicate that exon 3 of the human @GENE$ gene lacks association with @DISEASE$ in Japanese patients.

[ "1" ]

1473

Homozygosity for the @GENE$ 1186C variant is a weak risk factor for @DISEASE$ especially in older women.

[ "1" ]

1474

There is a subgroup of @DISEASE$ which develop via the MSI pathway that carry an alteration of the @GENE$ gene.

[ "0" ]

1475

The @GENE$ BstUI RFLP is associated with ATP and more specifically, chronic Achilles @DISEASE$.

[ "0" ]

1476

In our population DD @GENE$ genotype is associated with @DISEASE$ in young patients, although smoking, family history and hypercholesterolemia show a more powerful association.

[ "1" ]

1477

An increased susceptibility associated to the -169 T allele was found when MS patients and controls were compared, supporting the role of the @GENE$ locus in @DISEASE$ predisposition and therefore extending the evidence of its general influence on autoimmunity.

[ "1" ]

1478

Thus, neither HLA DMA nor DMB was associated with @DISEASE$ in this population, and not all shared-epitope-bearing haplotypes had the same @GENE$ allele distribution.

[ "1" ]

1479

The presence of the inhibitory allele @GENE$ in combination with the HLA-B*57s alleles that contain the Bw4-I80 epitope, has a highly protective effect against @DISEASE$ to AIDS in Zambian patients.

[ "0" ]

1480

These results indicate an association of the @GENE$ intron 4 variants and/or its flanking loci with mechanisms that may enhance @DISEASE$ susceptibility, especially to squamous cell carcinoma of the lung.

[ "1" ]

1481

Our results suggest that the @GENE$ functional polymorphisms analyzed do not seem to be implicated in genetic susceptibility to @DISEASE$.

[ "1" ]

1482

There are ethnic differences in the @GENE$ polymorphisms, and the polymorphisms are strongly associated with @DISEASE$.

[ "1" ]

1483

We found that XPA A23G and XPC Lys939Gln polymorphisms may be risk factors for @DISEASE$ and evidence that positive interactions between the polymorphisms in XPA/@GENE$ and XPC/XPD may occur.

[ "0" ]

1484

As its homologue @GENE$, CAPN5 seems to influence traits related to increased risk for @DISEASE$.

[ "0" ]

1485

Genetic linkage of @GENE$ and UGT1A9 polymorphisms to UGT1A1*6, related to reduced catalytic and transcriptional activities of UGTs, is associated with the decreased glucuronosyltransferase activity for SN-38 in Japanese patients with @DISEASE$.

[ "0" ]

1486

These results suggest that the @GENE$, RUNX1, and SUMO4 polymorphisms analyzed do not confer a relevant role in susceptibility to @DISEASE$ in the Spanish population.

[ "1" ]

1487

These data suggest that although there are marked ethnic differences in their distribution, the common genetic polymorphisms of the human @GENE$-adrenergic receptor gene do not cosegregate with the presence of @DISEASE$ in either black or white Americans.

[ "0" ]

1488

These results reveal that the @GENE$ gene polymorphism is associated with an increased risk of gastric atrophy induced by @DISEASE$ and might predispose to gastric cancer.

[ "0" ]

1489

The @GENE$ gene is significantly associated with @DISEASE$ susceptibility, suggesting the possibility that PD-1 may contribute to the pathogenesis of RA.

[ "1" ]

1490

the PS1 intronic polymorphism did not modify the risk for sporadic @DISEASE$, neither independently nor synergistically with the APOE epsilon4 allele or @GENE$ A allele, in Koreans.

[ "0" ]

1491

(1) @GENE$ * 0405 and DRB1 * 15 are closely associated with the susceptibility to VKH syndrome, DRB1 * 0405 may be the major susceptible gene and DRB1 * 15 may be the @DISEASE$; (2) DRB1 * 14 and DRB1 * 08 are negatively associated with the susceptibility to VKH syndrome, suggesting that they may be the resistant genes; (3) DRB1 * 0405 is not related to the clinical features, incidence of ocular complications as well as visual prognosis.

[ "0" ]

1492

These results suggest that the @GENE$ gene together with the aldose reductase gene are associated with susceptibility to DN in patients with @DISEASE$.

[ "0" ]

1493

Identification of @GENE$ mutations in 12.2% of patients with adult alcoholic and @DISEASE$ suggests an important role for SPINK1 as a predisposing factor in adult chronic pancreatitis.

[ "0" ]

1494

The @GENE$ genotype was not a significant or clinically relevant risk factor in the development of serious NSAID-related @DISEASE$ in this group of subjects.

[ "0" ]

1495

We conclude that the analyzed SNPs in @GENE$ and GALR1 do not play a major role in early onset @DISEASE$ or dietary fat intake in the obese children and adolescents of our study groups.

[ "1" ]

1496

These analyses suggest that variants of @GENE$ are not associated with risk of @DISEASE$.

[ "1" ]

1497

This study is the first to report an association between the @GENE$ gene and @DISEASE$.

[ "1" ]

1498

Observations from this study confirm earlier findings of a negative association between @GENE$*13 and @DISEASE$ and suggest that specific DRB1-DQB1 haplotype combinations, rather than individual DQB1*03 alleles, increase the risk for cervical cancer.

[ "1" ]

1499

We conclude that the human @GENE$ gene is rather involved in the development of @DISEASE$ and changes in total IgE levels than contributing to the pathogenesis of asthma.

[ "1" ]