qtype
stringclasses 1
value | Question
stringlengths 113
599
| Answer
stringlengths 58
185
|
|---|---|---|
drug_combination | What is the drug combination mentioned in the following sentence? m2 on day 1 , oxaliplatin 85 mg/m² day 1 and capecitabine twice-daily dose of 625 mg/ m2 , p.o . for 2 weeks ) every 3 | oxaliplatin capecitabine are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? However , two phase III trials demonstrated that incorporation of oxaliplatin to capecitabine with RT did not improve early outcomes and , by contrast , increased toxicity . | oxaliplatin capecitabine are the drug combinations. No need for context. It is a NEG combination. |
drug_combination | What is the drug combination mentioned in the following sentence? The addition of everolimus to bicalutamide treatment of resistant tumours significantly reduced tumour growth rates and tumour volumes . | everolimus bicalutamide are the drug combinations. No need for context. It is a POS combination. |
drug_combination | What is the drug combination mentioned in the following sentence? To assess plasma steady-state pharmacokinetics ( PK ) of rifampicin , isoniazid , saquinavir and ritonavir in HIV and tuberculosis ( TB ) co-infected patients , and investigate potential interactions between TB drugs and protease inhibitors ( PIs ) . | isoniazid saquinavir ritonavir rifampicin are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? We randomly assigned 808 patients with HER2-positive metastatic breast cancer to receive placebo plus trastuzumab plus docetaxel ( control group ) or pertuzumab plus trastuzumab plus docetaxel ( pertuzumab group ) as first-line treatment until the time of disease progression or the development of toxic effects that could not be effectively managed . | pertuzumab trastuzumab docetaxel are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? Toxicological studies revealed that the oral LD50 for thiabendazole in mice was 2200 mg/kg , and when combined with 140 mg/kg of aspirin , the LD50 was reduced to 900 mg/kg . | thiabendazole aspirin are the drug combinations. No need for context. It is a NEG combination. |
drug_combination | What is the drug combination mentioned in the following sentence? Azacitidine and enasidenib are two therapies available for treatment of acute myelogenous leukemia ( AML ) , and the mechanisms of action of these drugs involve alteration of aberrant DNA methylation . | Azacitidine enasidenib are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? Good , moderate and mild pain relief were noted in 19 ( 41 % ) , six ( 13 % ) and seven ( 15 % ) patients on lamotrigine and 13 ( 28 % ) , five ( 11 % ) and 15 ( 33 % ) patients on amitriptyline , respectively , by patient 's global assessment of efficacy and safety . | lamotrigine amitriptyline are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? The majority of the evidence comes from studies of bevacizumab and triamcinolone used as primary therapy for DMO . | bevacizumab triamcinolone are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? Doxorubicin and ifosfamide are currently the two main drugs for the treatment of soft tissue sarcomas in adults . | Doxorubicin ifosfamide are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? The skin and oral mucous membrane lesions recurred after effective treatments with methylprednisolone pulse therapy and combination therapy with prednisolone and cyclosporine . | prednisolone cyclosporine are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? Incorporation of colistin significantly accelerated the release of ciprofloxacin from the DMPG anionic liposomes . | colistin ciprofloxacin are the drug combinations. No need for context. It is a POS combination. |
drug_combination | What is the drug combination mentioned in the following sentence? Phase I study of decitabine in combination with vorinostat in patients with advanced solid tumors and non-Hodgkin 's lymphomas . | decitabine vorinostat are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? Epirubicin ( 35 mg/m(2 ) ) and cyclophosphamide ( 400 mg/m(2 ) ) were administered from day 2 to day 4 , every 4 weeks . | Epirubicin cyclophosphamide are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? Our patient could be weaned from LVAD probably due to the combination management strategy employing mitral valvuloplasty , use of cardiac resynchronization therapy , and taking carvedilol with spironolactone . | carvedilol spironolactone are the drug combinations. No need for context. It is a POS combination. |
drug_combination | What is the drug combination mentioned in the following sentence? Serum hydroxyzine and cetirizine concentrations were above the limit of quantitation ( 0.1 ng/ml ) of the assay | hydroxyzine cetirizine are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? Although well tolerated , the efficacy of everolimus and vinorelbine combination therapy was not superior to vinorelbine monotherapy . | everolimus vinorelbine are the drug combinations. No need for context. It is a NEG combination. |
drug_combination | What is the drug combination mentioned in the following sentence? In addition , biochemical examinations revealed that docetaxel could induce phosphorylation of both bcl-2 and c-raf-1 , but these changes were inhibited when tumor cells were pretreated or simultaneously treated with doxorubicin . | docetaxel doxorubicin are the drug combinations. No need for context. It is a NEG combination. |
drug_combination | What is the drug combination mentioned in the following sentence? Enhancement of radiation-induced downstaging of rectal cancer by fluorouracil and high-dose leucovorin chemotherapy . | fluorouracil leucovorin are the drug combinations. No need for context. It is a POS combination. |
drug_combination | What is the drug combination mentioned in the following sentence? Final analysis of a phase II study of nivolumab in combination with ipilimumab for unresectable chemotherapy-naive advanced melanoma . | nivolumab ipilimumab are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? In some relatively developed regions in China , infliximab and rituximab may be a favorable cost-effective alternative for moderate to severe RA . | infliximab rituximab are the drug combinations. No need for context. It is a POS combination. |
drug_combination | What is the drug combination mentioned in the following sentence? Topiramate CR treatment produced significant weight loss and meaningful improvements in A1C and blood pressure in obese patients with type 2 diabetes treated with diet and exercise or in combination with metformin . | Topiramate metformin are the drug combinations. No need for context. It is a POS combination. |
drug_combination | What is the drug combination mentioned in the following sentence? To compare efficacy and toxicity of bolus application of chemotherapy protocol , oxaliplatin , fluorouracil ( bolus ) , leucovorin ( folfox ) between two groups of patients in the therapy of metastatic colorectal carcinoma ( mCRC ) . | oxaliplatin fluorouracil leucovorin are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? Verapamil and quinine were added in patients with tumors failing to respond or progressing on CVAD alone . | Verapamil quinine are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? However , dipyridamole had no effect on both the influx and efflux of epirubicin in doxorubicin-sensitive cells . | dipyridamole epirubicin are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? This study aims to evaluate the potential role of combination therapy with docetaxel , flavopiridol , or 5-FU in modulating chemosensitivity and better understand how they might be used clinically . | docetaxel flavopiridol are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? Dipyridamole or dipyridamole and acetylsalicyclic acid were used in 22 pregnancies . | dipyridamole acetylsalicyclic acid are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? Bevacizumab and trastuzumab are efficacious for treatment of advanced or HER2-positive metastatic breast cancer ; however , few data exist for this regimen in inflammatory breast cancer . | Bevacizumab trastuzumab are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? Rats were distributed into three groups ( n = 5 ) according to the drug studied namely , 50 % enantiomeric excess bupivacaine mixture ( 5 μg/mL ) ; pancuronium ( 2 μg/mL ) ; 50 % enantiomeric excess bupivacaine mixture + pancuronium . | bupivacaine pancuronium are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? Blood was sampled immediately prior to premedication ( temazepam ) , after induction of anaesthesia ( fentanyl and thiopentone ) and at 10-minute intervals until the end of the procedure ( N2O maintenance , vecuronium relaxation ) . | temazepam fentanyl thiopentone vecuronium are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? The planned concomitant treatment in group B was : bleomycin 5 units twice a week i.m . , total dose 70 units , mitomycin C 15 mg/m2 i.v . after delivery of 10 Gy , and 10 mg/m2 i.v . on the last day of radiotherapy . | bleomycin mitomycin are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? The study objectives were to evaluate the safety , tolerability , and preliminary efficacy of multiple doses of dulanermin in combination with modified FOLFOX6 and bevacizumab in previously untreated patients with locally advanced , recurrent , or metastatic colorectal cancer . | dulanermin FOLFOX6 bevacizumab are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? The study was conducted in 90 patients operated on for unilateral breast cancer who were then assigned to receive either 12 intravenous cycles of cyclophosphamide , methotrexate and fluorouracil ( CMF ) every three weeks , or no further treatment . | cyclophosphamide methotrexate fluorouracil are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? This study compared the efficacy of topical emedastine 0.05 % ophthalmic solution with that of oral loratadine 10 mg and their combination in the conjunctival allergen challenge model of allergic conjunctivitis . | emedastine loratadine are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? Mycophenolate mofetil resulted in rapid improvement of steroid-refractory immune-related adverse event hepatitis , induced by nivolumab plus ipilimumab . | nivolumab ipilimumab are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? Resistant isolates emerged quickly and uniformly in all patients administered nevirapine either as monotherapy or in combination with zidovudine ( AZT ) . | nevirapine zidovudine are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? Postoperative combination chemotherapy for six cycles with cisplatin ( 100 mg/m2 per day for 1 day every 3 weeks ) , bleomycin ( 15 units intravenously weekly for 18 weeks ) and etoposide ( 100 mg/m2 per day for 3 days every 3 weeks ) were given and the tumor responded dramatically . | cisplatin bleomycin etoposide are the drug combinations. No need for context. It is a POS combination. |
drug_combination | What is the drug combination mentioned in the following sentence? The other received chemotherapy including prednisone , vincristine , cytarabine and L-asparaginase , combined with intrathecal injections of methotrexate , dexamethasone and Ara-C and supporting treatment . | prednisone vincristine cytarabine L-asparaginase are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? Then , neoadjuvant chemotherapy ( NAC ) consisting of a combination of 5-fluorouracil ( 5-FU ) , oxaliplatin , irinotecan , and leucovorin ( FOLFOXIRI ) was planned , followed by primary tumor resection . | 5-fluorouracil oxaliplatin irinotecan leucovorin are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? Interestingly , aspirin not only significantly inhibited the growth of TNBC cells , but also attenuated YAP and β-catenin expression by upregulating the E3 ubiquitin ligase β-TrCP to abolished docetaxel and vinorelbine resistance . | aspirin docetaxel vinorelbine are the drug combinations. No need for context. It is a POS combination. |
drug_combination | What is the drug combination mentioned in the following sentence? No alterations in paclitaxel or doxorubicin pharmacokinetics were observed when the drugs were administered alone versus in combination . | paclitaxel doxorubicin are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? Twenty-seven received rituximab mainly in addition to high-dose cytarabine and etoposide ( n = 18 ) and/or ifosfamide , carboplatin , and etoposide ( n = 7 ) . | rituximab cytarabine etoposide ifosfamide carboplatin etoposide are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? Both mono and combination therapies achieved the primary efficacy parameters : lowered diastolic blood pressure ( at trough ) more than placebo , p < 01 ( except the 120 mg verapamil SR , NS , 0.5 mg trandolapril , 0.5/180 and 2/120 combinations , p < 05 ) , yielded a trough to peak ratio of > 0.52 and had higher percentages of responders compared to placebo . | verapamil trandolapril are the drug combinations. No need for context. It is a POS combination. |
drug_combination | What is the drug combination mentioned in the following sentence? In metastastic patients , the combination of gemcitabine and cisplatin has become the new standard regimen due to a lower toxicity in comparison to the combination of methotrexate , vinblastine , doxorubicin , and cisplatin ( MVAC ) . | gemcitabine cisplatin are the drug combinations. No need for context. It is a POS combination. |
drug_combination | What is the drug combination mentioned in the following sentence? A randomized clinical trial of adjuvant chemotherapy with doxorubicin , ifosfamide , and cisplatin followed by radiotherapy versus radiotherapy alone in patients with localized uterine sarcomas ( SARCGYN study ) . | doxorubicin ifosfamide cisplatin are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? Combination therapy with irinotecan ( CPT-11 ) , 5-fluorouracil ( 5-FU ) and leucovorin is widely used for the treatment of metastatic colorectal cancer . | irinotecan leucovorin 5-fluorouracil are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? Long-term safety and outcome of fludarabine , cyclophosphamide and mitoxantrone ( FCM ) regimen in previously untreated patients with advanced follicular lymphoma : 12 years follow-up of a phase 2 trial . | fludarabine cyclophosphamide mitoxantrone are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? After clinical improvement under vemurafenib monotherapy , four cycles of ipilimumab were additionally administered . | vemurafenib ipilimumab are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? Bevacizumab plus paclitaxel versus bevacizumab plus capecitabine as first-line treatment for HER2-negative metastatic breast cancer ( TURANDOT ): primary endpoint results of a randomised , open-label , non-inferiority , phase 3 trial . | bevacizumab capecitabine are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? She underwent rectectomy and adjuvant chemotherapy with fluorouracil , leucovorin plus oxaliplatin for stage IIIB rectal cancer . | fluorouracil leucovorin oxaliplatin are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? We designed this phase II trial to evaluate the safety , tolerability , and efficacy of the combination of carboplatin , paclitaxel , cetuximab , and bevacizumab in chemotherapy-naive patients with advanced , nonsquamous NSCLC . | carboplatin paclitaxel cetuximab bevacizumab are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? All patients underwent mexiletine monotherapy ( M-mono ) , propafenone monotherapy ( P-mono ) , low dose combination therapy ( low M+P ) , and full dose combination therapy ( full M+P ) . | mexiletine propafenone are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? Cephalexin , 500 mg 4 times daily , plus trimethoprim-sulfamethoxazole , 320 mg/1600 mg twice daily , for 7 days ( n = 248 participants ) or cephalexin plus placebo for 7 days ( n = 248 participants ) . | Cephalexin trimethoprim-sulfamethoxazole are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? In the NALA trial , neratinib plus capecitabine led to increased PFS and time to intervention for central nervous system disease over the standard regimen of lapatinib plus capecitabine . | neratinib capecitabine are the drug combinations. No need for context. It is a POS combination. |
drug_combination | What is the drug combination mentioned in the following sentence? Since the patient had anemia , aspirin and cilostazol were discontinued after diagnosis . | aspirin cilostazol are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? This case report describes a patient with O-NHL which was possibly linked to the combination of methotrexate and etanercept for the treatment of her rheumatoid arthritis . | methotrexate etanercept are the drug combinations. No need for context. It is a NEG combination. |
drug_combination | What is the drug combination mentioned in the following sentence? In a prospective , pragmatic , randomised , parallel group study , 170 patients of mean ( SD ) age 37 ( 12 ) years with acute asthma ( peak expiratory flow ( PEF ) 212 ( 80 ) l/min ) presenting to hospital received treatment with either high dose prednisolone and continuous nebulised salbutamol as recommended in the US or lower dose prednisolone and bolus nebulised salbutamol as recommended in the UK by the BTS . | prednisolone salbutamol are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? We report a case of a 78-year-old white male ( weight , 90 kg ) presented to the Department of Medical Oncology and Hematology , Istituto Clinico Humanitas , Rozzano , Milan , Italy , with refractory MM immunoglobulin G kappa ( IgGkappa ) , Durie-Salmon Stage IIA , with progressive renal failure after an oral melphalan , prednisone , and thalidomide regimen ( 4 mg/m2.d , 40 mg/m2.d for 7 days every 6 weeks , and 100 mg/d , respectively ) . | melphalan prednisone thalidomide are the drug combinations. No need for context. It is a NEG combination. |
drug_combination | What is the drug combination mentioned in the following sentence? Following an intravitreal injection of ranibizumab , off-label administration of intravitreal dexamethasone was considered to reduce the edema . | ranibizumab dexamethasone are the drug combinations. No need for context. It is a POS combination. |
drug_combination | What is the drug combination mentioned in the following sentence? We performed a prospective , preplanned , pooled analysis of six randomized , phase 3 trials that were conducted concurrently to evaluate the noninferiority of adjuvant therapy with either FOLFOX ( fluorouracil , leucovorin , and oxaliplatin ) or CAPOX ( capecitabine and oxaliplatin ) administered for 3 months , as compared with 6 months . | capecitabine oxaliplatin are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? Growth inhibition and apoptosis were significantly ( P < 0.05 ) higher in BxPC-3 , HPAC , and PANC-1 cells treated with celecoxib and erlotinib than cells treated with either celecoxib or erlotinib . | celecoxib erlotinib are the drug combinations. No need for context. It is a POS combination. |
drug_combination | What is the drug combination mentioned in the following sentence? These results indicate that low-dose 100 microg levonorgestrel and 20 microg ethinyl estradiol given for 21 days is effective in suppressing ovarian activity and they confirm the contraceptive efficacy observed in clinical trials ( Pearl index of 0.8 ) . | levonorgestrel ethinyl are the drug combinations. No need for context. It is a POS combination. |
drug_combination | What is the drug combination mentioned in the following sentence? The combination of ixabepilone and capecitabine in the phase II study resulted in an ORR of 23 % in triple-negative patients . | ixabepilone capecitabine are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? We report the rare case of a 27-year-old premenopausal woman with locally advanced breast cancer that was marked by rapid tumor necrosis followed by massive hemorrhage shortly after bevacizumab and paclitaxel administration . | bevacizumab paclitaxel are the drug combinations. No need for context. It is a NEG combination. |
drug_combination | What is the drug combination mentioned in the following sentence? More recently , paclitaxel plus carboplatin also has been evaluated in previously untreated patients . | paclitaxel carboplatin are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? Mitoxantrone and cyclophosphamide in advanced breast cancer : a pilot study . | Mitoxantrone cyclophosphamide are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? We retrospectively analyzed the data of 37 patients who had postprandial hyperglycemia ( ≥10.0 mmol/L ) with BOT ( long-acting insulin plus glimepiride ) with their insulin titrated enough to keep preprandial glycemia < 7.2 mmol/L , and who had their treatment changed to liraglutide monotherapy , with the subsequent addition of glimepiride , when required . | liraglutide glimepiride are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? It was shown that the H2 receptor antagonist cimetidine when combined with N , N-diethyl-2-[4-(phenylmethyl)phenoxy]-ethanamine-HCl ( DPPE ) , a tamoxifen derivate , inhibits the proliferation of HT168 cells . | cimetidine DPPE N-diethyl-2-[4-(phenylmethyl)phenoxy]-ethanamine-HCl are the drug combinations. No need for context. It is a POS combination. |
drug_combination | What is the drug combination mentioned in the following sentence? We report here on a case of successful treatment of a patient suffering with severe liver dysfunction and metastatic gastric cancer ; the patient was treated with a combination of capecitabine and oxaliplatin ( XELOX ) . | capecitabine oxaliplatin are the drug combinations. No need for context. It is a POS combination. |
drug_combination | What is the drug combination mentioned in the following sentence? From 1987 to 1991 , 194 previously untreated patients received vincristine and ifosfamide plus dactinomycin or etoposide for 1 - 2 years . | vincristine ifosfamide dactinomycin are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? This nested substudy of the AVALON trial assessed the effects of coadministered amlodipine and atorvastatin vs. either therapy alone or placebo on arterial compliance , to evaluate the vascular benefits of coadministered therapy . | amlodipine atorvastatin are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? We analysed the serial dermatoscopic photographs of atypical melanocytic lesions taken from patients with advanced metastatic melanoma on four different systemic therapies ( selective BRAF-inhibitor monotherapy , dabrafenib combined with trametinib [ D&T ] , anti-programmed cell death protein 1 [ anti-PD1 ] therapies , and anti-PD1 combined with ipilimumab ) seen from February 2013 to May 2016 . | dabrafenib trametinib are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? He received six cycles MOPP-induction therapy followed by a chlorambucil maintenance therapy with procarbazine and prednisone reinforcements . | chlorambucil procarbazine prednisone are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? Frontline bortezomib and rituximab for the treatment of newly diagnosed high tumour burden indolent non-Hodgkin lymphoma : a multicentre phase II study . | bortezomib rituximab are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? The ifosfamide , carboplatin and etoposide ( ICE ) regimen was developed to address these challenges . | ifosfamide carboplatin etoposide are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? Effect of sequential treatments with alendronate , parathyroid hormone ( 1 - 34 ) and raloxifene on cortical bone mass and strength in ovariectomized rats . | alendronate parathyroid hormone raloxifene are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? Atorvastatin and metformin both have pleiotropic effects . | Atorvastatin metformin are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? Bevacizumab , a monoclonal antibody targeting vascular endothelial growth factor , is the first antiangiogenic drug to show improved efficacy when used in combination with irinotecan and oxaliplatin for first- and second-line treatment of CRC . | Bevacizumab irinotecan oxaliplatin are the drug combinations. No need for context. It is a POS combination. |
drug_combination | What is the drug combination mentioned in the following sentence? Between Oct 24 , 2016 , and Jan 24 , 2018 , 861 patients were randomly assigned to receive pembrolizumab plus axitinib ( n=432 ) or sunitinib monotherapy ( n=429 ) . | pembrolizumab axitinib are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? Patients received 175 mg/m of paclitaxel over a 3 h infusion , followed by nedaplatin 80 mg/m in a 1 h infusion on day 1 every 3 weeks for up to 6 treatment cycles . | paclitaxel nedaplatin are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? After a median follow-up of 9.5 years , 10-year OS rates in the bolus/infusional fluorouracil plus leucovorin ( LV5FU2 ) and LV5FU2 plus oxaliplatin ( FOLFOX4 ) arms were 67.1 % versus 71.7 % ( hazard ratio [ HR ] , 0.85 ; P = .043 ) in the whole population , 79.5 % versus 78.4 % for stage II ( HR , 1.00 ; P = .980 ) , and 59.0 % versus 67.1 % for stage III ( HR , 0.80 ; P = .016 ) disease . | fluorouracil leucovorin are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? [ Effects of combined use of dofetilide and verapamil on the action potential of papillary muscles in guinea pigs ] . | dofetilide verapamil are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? Patients with pancreatic adenocarcinoma , pre-treated with gemcitabine-based chemotherapy , were treated with capecitabine ( 800 mg/m(2 ) orally , twice a day for 14 days ) and docetaxel ( 75 mg/m(2 ) i.v , on day 1 ) , every 3 weeks . | capecitabine docetaxel are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? Comparative study of dose escalation versus interval reduction to obtain dose-intensification of epirubicin and cyclophosphamide with granulocyte colony-stimulating factor in advanced breast cancer . | epirubicin cyclophosphamide are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? The hearts were treated during the whole procedure either with vehicle , 0.5 μM flecainide ( sodium channel blocker ) or 100 μM streptomycin ( here used as stretch-activated ion-channel blocker ) . | flecainide streptomycin are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? In the APHINITY study ( NCT01358877 , BIG 4 - 11/BO25126/TOC4939 G ) , pertuzumab added to trastuzumab and chemotherapy significantly improved invasive disease-free survival as adjuvant treatment for patients with HER2-positive early breast cancer . | pertuzumab trastuzumab are the drug combinations. No need for context. It is a POS combination. |
drug_combination | What is the drug combination mentioned in the following sentence? In two trials , an anti-EGFR antibody ( panitumumab or cetuximab ) reduced median survival when added to bevacizumab in previously untreated patients . | panitumumab bevacizumab are the drug combinations. No need for context. It is a NEG combination. |
drug_combination | What is the drug combination mentioned in the following sentence? The results of the APPEARANCE trial indicate that adapalene does not prevent acne-like rash over placebo when added to topical moisturizer and oral minocycline but instead may have a detrimental effect . | adapalene minocycline are the drug combinations. No need for context. It is a NEG combination. |
drug_combination | What is the drug combination mentioned in the following sentence? Both regimens included cyclophosphamide , methotrexate , 5-FU , prednisone , and doxorubicin . | cyclophosphamide doxorubicin are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? A Randomized , Multicenter , Double-blind , Phase III Study to Evaluate the Efficacy on Allergic Rhinitis and Safety of a Combination Therapy of Montelukast and Levocetirizine in Patients With Asthma and Allergic Rhinitis . | Montelukast Levocetirizine are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? Intravenous administration of cefoperazone and sulbactam given as individual agents compared with the combination did not show pharmacokinetic differences that are likely to produce clinically relevant effects . | cefoperazone sulbactam are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? HDC with cyclophosphamide , carmustine and thiotepa was given from day -7 to -5 . | cyclophosphamide carmustine thiotepa are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? A recently reported phase II trial has demonstrated that trastuzumab plus vinorelbine is both effective ( overall response rate 75 % ) and well tolerated , with the major side effects being typical of single-agent vinorelbine . | trastuzumab vinorelbine are the drug combinations. No need for context. It is a POS combination. |
drug_combination | What is the drug combination mentioned in the following sentence? Differences were observed when palbociclib or ribociclib was used in combination with letrozole or anastrozole or fulvestrant . | palbociclib letrozole are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? Resolution of muscle damage followed discontinuation of cyclosporine and lovastatin therapy . | cyclosporine lovastatin are the drug combinations. No need for context. It is a NEG combination. |
drug_combination | What is the drug combination mentioned in the following sentence? Primary chemotherapy with gemcitabine , liposomal doxorubicin and docetaxel in patients with locally advanced breast cancer : results of a phase I trial . | gemcitabine doxorubicin docetaxel are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? The aim of this single-blind , randomized , controlled trial was to investigate treatment efficacy and safety of aripiprazole as an adjunct to valproic acid ( Ari+Val ) , compared with haloperidol plus valproic acid ( Hal+Val ) , in acute manic patients . | aripiprazole valproic are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? Because the incidence of nausea and vomiting is significantly reduced when ketorolac is used in place of opioids to attenuate postoperative pain , it would appear to be an appropriate choice of agent to use following propofol anesthesia . | ketorolac propofol are the drug combinations. No need for context. It is a POS combination. |
drug_combination | What is the drug combination mentioned in the following sentence? The combination of vandetanib and bicalutamide was associated with considerable toxicity and did not have superior efficacy over bicalutamide alone . | vandetanib bicalutamide are the drug combinations. No need for context. It is a NEG combination. |
drug_combination | What is the drug combination mentioned in the following sentence? Our data indicate that the addition of Aspirin or of Atenolol to Metformin might be beneficial for BC control , and that this activity is likely due to effects on both BC and microenvironment cells . | Aspirin Metformin are the drug combinations. No need for context. It is a POS combination. |