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After the addition of citalopram, a desmethylclomipramine plasma level increase and an 8-hydroacy-desmethylclomipramine plasma level decrease were observed.
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We report 3 cases of HIV-1 infected patients who experienced symptomatic angiolipomas shortly after starting antiretroviral therapy including the protease inhibitor indinavir.
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Elevated serum triglycerides with clozapine resolved with risperidone in four patients.
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In two patients clozapine was reinstated after risperidone was discontinued; serum triglyceride levels increased.
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This increase when clozapine was switched to risperidone and vice versa is consistent with our previous report of elevated serum triglyceride levels in clozapine-treated patients.
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Intravenous valproate associated with significant hypotension in the treatment of status epilepticus.
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To our knowledge, this is the first report of significant hypotension associated with intravenous valproate in the treatment of status epilepticus in the pediatric population.
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We report a case of severe hypotension associated with intravenous valproate used to treat status epilepticus in an 11-year-old girl.
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In both patients the rippling phenomena worsened with pyridostigmine treatment but markedly improved after immunosuppression with azathioprine.
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A diagnosis of masked theophylline poisoning should be considered in similar situations involving a rapid decrease of insulin requirements.
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Salicylate intoxication was excluded, and theophylline was finally incriminated.
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Theophylline intoxication mimicking diabetic ketoacidosis in a child.
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This compound, used by adults in the child's home, had caused accidental theophylline poisoning, mimicking diabetic ketoacidosis.
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Methylene blue in the treatment and prevention of ifosfamide-induced encephalopathy: report of 12 cases and a review of the literature.
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Ten to 15% of patients treated with ifosfamide develop an encephalopathy.
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We conclude that MB is an effective treatment for ifosfamide-induced encephalopathy.
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Portal vein thrombosis in a patient with severe haemophilia A and F V G1691A mutation during continuous infusion of F VIII after intramural jejunal bleeding--successful thrombolysis under heparin therapy.
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We report on a 14-year-old boy with severe haemophilia A who developed a portal vein thrombosis during continuous infusion of F VIII.
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A 60-year-old woman with diabetes mellitus (type 2) developed an acute icteric hepatitis-like illness 6 weeks after the initiation of gliclazide therapy.
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Gliclazide-induced acute hepatitis.
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In conclusion, this case strongly suggests that gliclazide can induce acute icteric liver necro-inflammation which may be misdiagnosed clinically as acute viral hepatitis.
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We believe that this is the first description of acute hepatitis caused by an idiosyncratic adverse reaction to gliclazide or to one of its metabolites.
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We describe the case of acute hepatitis induced by gliclazide, a second generation sulfonylurea.
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Caution is, therefore, needed to prevent undesired accumulation of TCA that may lead to protracted Cushing's syndrome.
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Cushing's syndrome persisted more than 6 months while TCA concentrations remained detectable for at least 80 days.
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The presented patient was treated with 200 mg TCA and developed Cushing's syndrome 6 weeks later (cortisol and ACTH concentrations were below limits of detection, TCA concentrations were > 3 micrograms/l).
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Both had impaired lung function and abnormal computed tomographic scans, and their condition improved when nitrofurantoin was withdrawn and corticosteroid treatment commenced.
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Both had impaired lung function and abnormal computed tomographic scans, and their condition improved when nitrofurantoin was withdrawn and corticosteroid treatment commenced.
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Bronchiolitis obliterans organising pneumonia associated with the use of nitrofurantoin.
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The case histories are presented of two patients who developed lung disease associated with the use of nitrofurantoin with histological features of bronchiolitis obliterans organising pneumonia (BOOP), a rare but recognised form of drug induced injury.
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The case histories are presented of two patients who developed lung disease associated with the use of nitrofurantoin with histological features of bronchiolitis obliterans organising pneumonia (BOOP), a rare but recognised form of drug induced injury.
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The case histories are presented of two patients who developed lung disease associated with the use of nitrofurantoin with histological features of bronchiolitis obliterans organising pneumonia (BOOP), a rare but recognised form of drug induced injury.
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The favourable outcome in these two patients contrasts with the fatal outcome of the two other reported cases of nitrofurantoin induced BOOP.
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The favourable outcome in these two patients contrasts with the fatal outcome of the two other reported cases of nitrofurantoin induced BOOP.
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The spectrum of nitrofurantoin lung injury continues to widen.
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The two middle aged women presented with respiratory symptoms after prolonged treatment with nitrofurantoin.
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We suggest that the previous classification of nitrofurantoin induced lung injury into "acute" and "chronic" injury is an oversimplification in view of the wide variety of pathological entities that have subsequently emerged.
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Intravenous administration of levodopa ameliorated a refractory akathisia case induced by interferon-alpha.
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The present report illustrates a rare case of refractory akathisia after interferon-alpha treatment and also that levodopa treatment would be theoretically and practically useful in reducing the neurotoxicity associated with interferon-alpha.
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The present report illustrates a rare case of refractory akathisia after interferon-alpha treatment and also that levodopa treatment would be theoretically and practically useful in reducing the neurotoxicity associated with interferon-alpha.
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Acute erythroid leukemia after cyclophosphamide therapy for multiple myeloma: report of two cases.
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The development of erythroid leukemia plus carcinoma in these two men suggests mutagenic change secondary to cyclophosphamide therapy.
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Scleroderma-like reaction induced by uracil-tegafur (UFT), a second-generation anticancer agent.
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Scleroderma-like reaction induced by uracil-tegafur (UFT), a second-generation anticancer agent.
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This is the first report of UFT-induced scleroderma-like reaction.
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We report a case of a scleroderma-like reaction induced by long-term administration of UFT.
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Central nervous system manifestations of an ibuprofen overdose reversed by naloxone.
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Ibuprofen overdose is usually characterized by GI upset, dizziness, and mild sedation.
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Ibuprofen overdose is usually characterized by GI upset, dizziness, and mild sedation.
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Ibuprofen overdose is usually characterized by GI upset, dizziness, and mild sedation.
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Presently, treatment of acute ibuprofen intoxication with complications requires supportive therapy until the symptoms resolve over 24 to 48 hours.
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We report the case of an 11-month-old female infant with a depressed level of consciousness after ingestion of ibuprofen whose mental status markedly improved with administration of naloxone.
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Flecainide-associated pneumonitis with acute respiratory failure in a patient with the LEOPARD syndrome.
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Flecainide-associated pneumonitis with acute respiratory failure in a patient with the LEOPARD syndrome.
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Flecainide is a rare cause of hypersensitivity pneumonitis, and few cases have been reported.
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We describe a case of interstitial hypoxaemiant pneumonitis probably related to flecainide in a patient with the LEOPARD syndrome, a rare congenital disorder.
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Sagittal sinus thrombosis associated with transient free protein S deficiency after L-asparaginase treatment: case report and review of the literature.
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Sagittal sinus thrombosis associated with transient free protein S deficiency after L-asparaginase treatment: case report and review of the literature.
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We report the case of an adult patient with acute lymphoblastic leukemia who presented with repeated transient ischemic attacks followed by a seizure during consolidation treatment with L-asparaginase.
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We report the case of an adult patient with acute lymphoblastic leukemia who presented with repeated transient ischemic attacks followed by a seizure during consolidation treatment with L-asparaginase.
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We report on a young adolescent with benign intracranial hypertension which we attribute to the use of minocycline for acne.
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We report 2 patients who developed polyarteritis nodosa following vaccination against hepatitis B.
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In this case, it was suspected that a combination of cigarette smoking, pulmonary fibrosis, and low-dose methotrexate therapy might have promoted the development of lung cancer.
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This case report illustrates the use of continuous high-dose intracoronary nitroglycerin infusion through a 6 French coronary guiding catheter in the treatment of a patient with cocaine-induced refractory coronary vasospasm.
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However, as illustrated by these and other cases reported to date, the onset of troglitazone-induced liver injury is insidious and temporally variable.
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It remains to be seen whether the hepatotoxicity associated with troglitazone is a drug-class effect or specific to troglitazone.
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It remains to be seen whether the hepatotoxicity associated with troglitazone is a drug-class effect or specific to troglitazone.
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Other thiazolidinediones currently in clinical trials may be able to provide the therapeutic benefits of troglitazone without significant hepatotoxicity.
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The three reported cases demonstrate that troglitazone is an idiosyncratic hepatotoxin that can lead to irreversible liver injury.
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Troglitazone-induced fulminant hepatic failure.
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Nitrofurantoin-induced lung disease: two cases demonstrating resolution of apparently irreversible CT abnormalities.
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We present two cases of nitrofurantoin-induced pulmonary toxicity in which the initial HRCT showed a widespread reticular pattern and associated distortion of the lung parenchyma, thought to represent established fibrosis.
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We present two cases of nitrofurantoin-induced pulmonary toxicity in which the initial HRCT showed a widespread reticular pattern and associated distortion of the lung parenchyma, thought to represent established fibrosis.
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We present two cases of nitrofurantoin-induced pulmonary toxicity in which the initial HRCT showed a widespread reticular pattern and associated distortion of the lung parenchyma, thought to represent established fibrosis.
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We present two cases of nitrofurantoin-induced pulmonary toxicity in which the initial HRCT showed a widespread reticular pattern and associated distortion of the lung parenchyma, thought to represent established fibrosis.
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Fluoxetine-related death in a child with cytochrome P-450 2D6 genetic deficiency.
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The medical examiner's report indicated death caused by fluoxetine toxicity.
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The medical examiner's report indicated death caused by fluoxetine toxicity.
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This is the first report of a fluoxetine-related death in a child with a confirmed genetic polymorphism of the CYP2D6 gene that results in impaired drug metabolism.
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A 50-year-old woman with a history of migraine without aura, predominantly occurring around her menstrual periods, developed a spinal cord lesion following the use of zolmitriptan.
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Spinal cord infarction during use of zolmitriptan: a case report.
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The temporal relationship suggests that the spinal cord infarction may be related to the use of zolmitriptan.
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CASE SUMMARY: A 10-year-old white girl with bilateral optic glioma developed a hypersensitivity reaction to carboplatin after nine courses.
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This regimen could prove useful for other patients who develop hypersensitivity reactions to carboplatin and allow therapy to continue.
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Perinatal vasoconstrictive renal insufficiency associated with maternal nimesulide use.
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This is the first report of an adverse effect of fetal renal circulation by maternal ingestion of nimesulide.
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Although the t-AML developed following oral etoposide therapy, the child had previously received high-dose, multiagent chemotherapy, and rearrangement of the MLL gene was not demonstrated.
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Secondary leukemia in a child with neuroblastoma while on oral etoposide: what is the cause?
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The authors present a case of t-AML that developed in a child with metastatic neuroblastoma 18 months after he received oral etoposide, given for palliation purpose.
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BACKGROUND: Cyanamide, an aversive agent widely used in Japan, is known to induce various degrees of hepatic lesion with ground-glass inclusion bodies.
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Case 2: A 43-year-old male alcoholic remained completely abstinent with cyanamide treatment for 5 years and complained of general fatigue.
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Case 3: A 29-year-old female alcoholic complained of general fatigue and a slight fever after 1.5 years of abstinence with cyanamide treatment.
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Case 3: A 29-year-old female alcoholic complained of general fatigue and a slight fever after 1.5 years of abstinence with cyanamide treatment.
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Case 4: A 61-year-old male alcoholic who remained completely abstinent while taking cyanamide for 3 years showed slight elevation of serum transaminases.
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CONCLUSION: In some abstainers who take cyanamide for several years, thin septum-like liver fibrosis progresses along with the emergence of ground-glass hepatocytes.
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CONCLUSION: In some abstainers who take cyanamide for several years, thin septum-like liver fibrosis progresses along with the emergence of ground-glass hepatocytes.
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Cyanamide-induced liver dysfunction after abstinence in alcoholics: a long-term follow-up study on four cases.
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When cyanamide-treated alcoholics relapse into drinking, more severe inflammation develops in the liver.
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A patient with an allergy to a macrolide antibiotic was given tacrolimus and developed a sudden cutaneous reaction.
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A 77-year-old woman with no history of epilepsy presented a probable nonconvulsive status epilepticus while receiving continuous intravenous morphine for back pain relating to vertebral metastasis of a malignant lymphoma.
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