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Prooxidant-antioxidant shift induced by androgen treatment of human prostate carcinoma cells. | various parameters of oxidative state (e.g.; generation of hydrogen peroxide and hydroxyl radicals; lipid peroxidation; and oxygen consumption) and antioxidant defense mechanisms (e.g.; the glutathione system and catalase).The androgen-responsive LNCaP and the androgen-independent DU145 prostate carcinoma cell lines were exposed to 5 alpha-dihydrotestosterone (DHT) and to the synthetic androgen R1881. The cellular proliferation responses were measured by use of a fluorometric assay to quantitate the amount | 8978405 | [
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Prooxidant-antioxidant shift induced by androgen treatment of human prostate carcinoma cells. | of DNA. The generation of reactive oxygen species was measured by use of 2';7'-dichlorofluorescin diacetate; a dye that fluoresces in the presence of hydrogen peroxide or hydroxyl radicals. Lipid peroxidation was quantitated by use of a chromogen specific for malonaldehyde and 4-hydroxy-2(E)-nonenal. General mitochondrial activity was determined by assaying 3-(4;5-dimethylthiazol-2-yl)-2;5-diphenyltetrazolium bromide (MTT) reduction. A Clark-type electrode was used to assess oxygen consumption per cell. In | 8978405 | [
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Prooxidant-antioxidant shift induced by androgen treatment of human prostate carcinoma cells. | tracellular glutathione concentrations and the activities of catalase and gamma-glutamyl transpeptidase were measured spectrophotometrically. All P values resulted from two-sided tests.DHT at less than 1 to 100 nM (a concentration range encompassing the physiologic levels of DHT considering all ages) and R1881 at 0.1-1 nM concentrations were effective in inducing in LNCaP cells comparable proliferative responses and changes in oxidative stress. In contrast; neither DHT nor R1881 had any effect on the oxidat | 8978405 | [
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Prooxidant-antioxidant shift induced by androgen treatment of human prostate carcinoma cells. | ive stress in DU145 cells. The mitochondrial activity in LNCaP cells; as measured by MTT reduction; was significantly elevated above the levels of the untreated controls by DHT (0.1-1000 nM) and R1881 (0.05-1 nM) (P < .001 in both). Oxygen consumption and catalase activity were increased in LNCaP cells in the presence of 1 nM R1881 by 60% and 40%; respectively; over the values in the untreated control cells (P < .03 and P < .01; respectively). The same concentration of R1881 resulted in a decrease in intrac | 8978405 | [
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Prooxidant-antioxidant shift induced by androgen treatment of human prostate carcinoma cells. | ellular glutathione concentrations and an increase in gamma-glutamyl transpeptidase activity in LNCaP cells. Treatment with the oxidizing agents H2O2 and menadione produced an increase in gamma-glutamyl transpeptidase activity in LNCaP cells; whereas treatment with the antioxidant compound ascorbic acid (100 mM) reduced the oxidative stress produced in LNCaP cells by 1 nM R1881 and completely blocked the gamma-glutamyl transpeptidase activity.Physiologic levels of androgens are capable of increasing oxidati | 8978405 | [
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Prooxidant-antioxidant shift induced by androgen treatment of human prostate carcinoma cells. | ve stress in androgen-responsive LNCaP prostate carcinoma cells. The evidence suggests that this result is due in part to increased mitochondrial activity. Androgens also alter intracellular glutathione levels and the activity of certain detoxification enzymes; such as gamma-glutamyl transpeptidase; that are important for maintenance of the cellular prooxidant-antioxidant balance. | 8978405 | [
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Assessing changes in the impact of cancer on population survival without considering cause of death. | We have previously argued against the calculation of cancer-specific death rates as philosophically undefined and biased. Deaths attributed to cancer during a particular year occur in patients diagnosed during an unknown distribution of past times; so cancer-specific death rates cannot be used to assess changes in the impact of cancer on survival of the population at specific periods of diagnosis.Our goal was to develop and analyze three measures of the impact of cancer on population survival that do not us | 8978407 | [
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Assessing changes in the impact of cancer on population survival without considering cause of death. | e the attributed cause of death: 1) the age-adjusted proportion of the population diagnosed with cancer in a particular year and projected to be dead of any cause by a particular age; 2) the same measure corrected for population mortality; and 3) the expected years of life lost to a 20-year-old individual because of the possibility of a diagnosis of cancer.Data on all adults diagnosed with any cancer during the period from January 1973 through December 1990 were obtained from the Surveillance; Epidemiology; | 8978407 | [
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Assessing changes in the impact of cancer on population survival without considering cause of death. | and End Results (SEER) Program of the National Cancer Institute. The measures were calculated separately for various combined sex and race groups. Three 2-year diagnosis periods spaced 5 years apart were considered: 1975-1976; 1980-1981; and 1985-1986. A statistical model was used to extrapolate survival beyond observation; the same model was used for patients diagnosed in the three time periods to minimize the effect of possible model misspecification on changes.Cancer incidence increased for three of the | 8978407 | [
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Assessing changes in the impact of cancer on population survival without considering cause of death. | four sex-race groups; age-adjusted changes from 1975 through 1976 to 1985 through 1986 were +11.5% for white men; +6.9% for white women; +15.1% for black men; and -9.2% for black women. Human immunodeficiency virus (HIV)-related cancers were responsible for an increased cancer incidence at early ages in white men in the latest time period studied. There was a decrease in the incidence of gynecologic cancers at early ages; the decrease was greater among black women (-55.1%) than among white women (-39.3%). | 8978407 | [
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Assessing changes in the impact of cancer on population survival without considering cause of death. | Age- and incidence-adjusted 5-year survival increased by 17.9% for white men; 2.3% for white women; and 7.4% for black men and decreased by 14.1% for black women. When the data from 1985 through 1986 were compared with those from 1975 through 1976; the expected number of years lost to a 20-year-old individual because of cancer changed as follows for the various sex-race groups: +1.4% for white men (-4.0% if HIV-related cancers were not included in the calculation); +2.1% for white women; +12.2% for black me | 8978407 | [
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Assessing changes in the impact of cancer on population survival without considering cause of death. | n; and +8.8% for black women.For white men and women; there has been an increase in both the incidence of and survival following the diagnosis of cancer; the two effects nearly cancel in our measures. The experience of black men and women has worsened because of increasing incidence or decreased survival. | 8978407 | [
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Lung cancer risk from residential radon: meta-analysis of eight epidemiologic studies. | Studies of underground miners exposed to radioactive radon and its decay products have found that exposure increases risk of lung cancer. Consequently; when radon was found to accumulate in houses; there was concern about the public health impact from exposure to a known carcinogen. Estimates on the basis of studies of underground miners suggest that indoor radon may account for 6000-36;000 lung cancer deaths each year in the United States. Because of differences between working in underground mines and liv | 8978406 | [
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Lung cancer risk from residential radon: meta-analysis of eight epidemiologic studies. | ing in houses; estimates are subject to major uncertainties. Numerous case-control studies were launched to assess directly the lung cancer risk from indoor radon. Some studies report positive or weakly positive findings; while others report no increased risk. Thus; the potential hazard from indoor radon remains answered only indirectly through miner studies; experimental animal studies; and cellular studies.To provide more information on the risk of lung cancer from indoor radon; we conducted a meta-analys | 8978406 | [
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Lung cancer risk from residential radon: meta-analysis of eight epidemiologic studies. | is of all case-control studies that included at least 200 case subjects each and that used long-term indoor radon measurements.Eight studies were available and included a total of 4263 lung cancer case subjects and 6612 control subjects. From the published results of each study; confounder-adjusted relative risk (RR) estimates and 95% confidence intervals (CIs) for categories of radon concentration were obtained; and weighted linear regression analyses were performed.The combined trend in the RR was signifi | 8978406 | [
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Lung cancer risk from residential radon: meta-analysis of eight epidemiologic studies. | cantly different from zero (two-sided P = .03); and an estimated RR of 1.14 (95% CI = 1.0-1.3) at 150 Bq/m3 was found. An influence analysis indicated that no single study dominated the combined results. The exposure-response trend was similar to model-based extrapolations from miners and to RRs computed directly from miners with low cumulative exposures. However; there were significant differences in the study-specific estimates of the exposure response (two-sided P < .001); which were not explained by stu | 8978406 | [
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Lung cancer risk from residential radon: meta-analysis of eight epidemiologic studies. | dy differences in percent of the defined exposure interval covered by radon measurements; mean number of residences per subject; and other factors.Meta-analyses are valuable for identifying differences among studies and for summarizing results; but they should be interpreted cautiously when expected RRs are low as with indoor radon exposure; when there is study heterogeneity and where there is the potential for confounding and exposure misclassification. Nonetheless; the results of this meta-analysis sugges | 8978406 | [
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Lung cancer risk from residential radon: meta-analysis of eight epidemiologic studies. | t that the risk from indoor radon is not likely to be markedly greater than that predicted from miners and indicate that the negative exposure response reported in some ecologic studies is likely due to model misspecification or uncontrolled confounding and can be rejected.Until ongoing case-control studies of indoor radon are completed and the data are pooled and analyzed; the studies of underground miners remain the best source of data to use to assess risk from indoor radon. This meta-analysis provides s | 8978406 | [
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Lung cancer risk from residential radon: meta-analysis of eight epidemiologic studies. | upport for their general validity. | 8978406 | [
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p53 abnormalities in primary prostate cancer: single-strand conformation polymorphism analysis of complementary DNA in comparison with genomic DNA. The Cooperative Prostate Network. | The reported frequency of mutation of the p53 tumor suppressor gene (also known as TP53) in human carcinomas of the prostate has varied widely; ranging from 3% to 42%. This variability may be a consequence of tumor heterogeneity and/or the use of different methods of analysis. Since p53 mutation has been associated with clinical outcome for a number of cancer types; determination of its true frequency in primary carcinomas of the prostate is important.The principal aims of this study were as follows: 1) to | 8978408 | [
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p53 abnormalities in primary prostate cancer: single-strand conformation polymorphism analysis of complementary DNA in comparison with genomic DNA. The Cooperative Prostate Network. | validate the utility of detecting p53 gene mutations by means of polymerase chain reaction-single-strand conformation polymorphism (PCR-SSCP) analysis of complementary DNA (cDNA) (synthesized from prostate tissue RNA and 2) to study the concordance of RNA- and DNA-based PCR-SSCP assays in detecting p53 mutations in individual tumor fragments.RNA and genomic DNA were isolated by means of standard techniques from specimens of 19 carcinomas of the prostate; selected on the basis of p53 data obtained in a previ | 8978408 | [
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p53 abnormalities in primary prostate cancer: single-strand conformation polymorphism analysis of complementary DNA in comparison with genomic DNA. The Cooperative Prostate Network. | ous analysis of cDNA (indicating that 14 were mutant and five were wild-type). RNA was converted into cDNA by means of reverse transcription (RT); the cDNA was then amplified by means of nonisotopic (i.e.; nonradioactive) PCR; and the PCR products were subjected to SSCP analysis in polyacrylamide gels (RT-PCR-SSCP analysis). Genomic DNA was examined by means of SSCP analysis of isotopically labeled (32PO4) PCR products (DNA-PCR-SSCP analysis). In both approaches; the protein coding region of the p53 gene wa | 8978408 | [
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p53 abnormalities in primary prostate cancer: single-strand conformation polymorphism analysis of complementary DNA in comparison with genomic DNA. The Cooperative Prostate Network. | s divided into multiple; smaller fragments for study. PCR products exhibiting abnormal migration in SSCP gels were subjected to direct nucleotide sequencing or to cloning and sequencing of multiple clones.RT-PCR-SSCP and DNA-PCR-SSCP identified p53 gene abnormalities in 15 of the 19 selected carcinomas; including one previously reported to be wild-type for p53. Overall; PCR-SSCP analysis identified 18 p53 fragments with abnormalities; three carcinomas showed two abnormalities each. Six (33%) of the 18 abnor | 8978408 | [
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p53 abnormalities in primary prostate cancer: single-strand conformation polymorphism analysis of complementary DNA in comparison with genomic DNA. The Cooperative Prostate Network. | malities were detected by both RT-PCR-SSCP and DNA-PCR-SSCP; 10 (56%) were detected by RT-PCR-SSCP alone; and two (11%) were detected by DNA-PCR-SSCP alone. The 18 abnormalities were caused by 20 changes in the sequence of the p53 gene; in one carcinoma; double mutations in two individual p53 exons were identified.PCR-SSCP analysis of both RNA and DNA allows the detection of more mutations than the analysis of either alone. Some primary carcinomas of the prostate contain more than one altered p53 gene; cons | 8978408 | [
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p53 abnormalities in primary prostate cancer: single-strand conformation polymorphism analysis of complementary DNA in comparison with genomic DNA. The Cooperative Prostate Network. | istent with the possibility of intratumoral heterogeneity of mutation of this gene. For comprehensive analysis of p53 mutations in carcinomas of the prostate; and perhaps in other tumor tissues; SSCP analysis of cDNA should be used in combination with SSCP analysis of genomic DNA. | 8978408 | [
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Intrauterine environment and breast cancer risk in women: a population-based study. | The established risk factors for female breast cancer; including nulliparity; age at first birth; age at menarche; and age at menopause; do not adequately explain the occurrence pattern of this cancer. Therefore; additional factors need to be considered to advance our understanding of the causes of breast cancer. Evidence obtained from animals and humans indicates that the perinatal period may be particularly important. Our earlier studies; based on a subsample of the present investigation; suggested that f | 8978409 | [
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Intrauterine environment and breast cancer risk in women: a population-based study. | actors thought to be positively associated with estrogen levels during pregnancy are positively associated with breast cancer risk. However; the associated confidence intervals (CIs) were generally wide; indicating considerable variability in the data.We studied a large number of incident breast cancer case patients and evaluated several perinatal variables in relation to breast cancer risk. These variables included some not previously studied; such as gestational age and neonatal jaundice. We also investig | 8978409 | [
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Intrauterine environment and breast cancer risk in women: a population-based study. | ated twin membership as a predictor variable and death from breast cancer; in addition to occurrence of breast cancer; as an alternative outcome variable.Birth records for all deliveries at five different hospitals in Sweden during the period from 1874 through 1961 were used to define a large cohort of women. Incident case patients with breast cancer in this cohort were ascertained through the National Cancer Registry or the Uppsala Regional Cancer Registry from 1958 through 1994. In a case-control study ne | 8978409 | [
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Intrauterine environment and breast cancer risk in women: a population-based study. | sted in the cohort; we abstracted data from birth records on 1068 women with incident breast cancer and on 2727 control subjects individually matched to the case patients on date of birth. We modeled the data through conditional logistic regression. All P values were derived from two-sided statistical tests.We found a markedly reduced risk for breast cancer in women whose mothers had pregnancy toxemia (odds ratio [OR] = 0.41; 95% CI = 0.22-0.79) and an excess risk on women who had neonatal jaundice (OR = 2. | 8978409 | [
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Intrauterine environment and breast cancer risk in women: a population-based study. | 16; 95% CI = 1.27-3.67) or who were born before 33 weeks of gestation (OR = 3.96; 95% CI = 1.45-10.81). Compared with the risk for breast cancer in the singleton; the risk for breast cancer in dizygotic twins was increased; although this increase was not statistically significant (OR = 1.72; 95% CI = 0.92-3.20). There was no evidence in these data for a statistically significant or substantial association of breast cancer risk with birth size indicators (i.e.; weight and length at birth and placental weight | 8978409 | [
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Intrauterine environment and breast cancer risk in women: a population-based study. | ).Because pregnancy toxemia is associated with low levels of estrogens and neonatal jaundice; severe prematurity; and dizygotic twins with high levels of estrogens; our findings suggest that estrogens and other hormonal factors; known to influence breast cancer risk in the adult; may also play a critical role during the intrauterine period. | 8978409 | [
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Comparison of risk factors for ductal carcinoma in situ and invasive breast cancer. | Ductal carcinoma in situ (DCIS) accounts for approximately 12% of newly diagnosed breast cancers. Knowledge of the factors that predict who will be diagnosed with DCIS is very limited.The goal of this study was to determine risk factors associated with DCIS and whether these risk factors are similar to those associated with invasive breast cancer.We conducted a cross-sectional study of 39;542 women aged 30 years and older who underwent a screening mammographic examination at the University of California San | 8978410 | [
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Comparison of risk factors for ductal carcinoma in situ and invasive breast cancer. | Francisco Mobile Mammography Screening Program from April 1985 through September 1995. A breast cancer risk profile and clinical history were obtained for each woman. Follow-up after abnormal mammography was performed to determine the presence of DCIS or invasive breast cancer by contacting the women's physicians and by linkage to the regional Surveillance; Epidemiology; and End Results cancer registry. Multivariate analysis was performed by the use of polytomous logistic regression. Two-sided statistical | 8978410 | [
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Comparison of risk factors for ductal carcinoma in situ and invasive breast cancer. | tests were used to determine P values.Among women aged 30-49 years; a family history of breast cancer (i.e.; at least one affected first degree relative) was associated with an increased risk of DCIS (Odds ratio [OR] = 2.4; 95% confidence interval [CI] = 1.1-4.9) and body mass index greater than or equal to 25 kg/m2 was associated with a decreased risk of DCIS (OR = 0.4; 95% CI = 0.2 to 0.9). For each of these factors; there was a trend in the same direction bordering on statistical significance for invasiv | 8978410 | [
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Comparison of risk factors for ductal carcinoma in situ and invasive breast cancer. | e cancer (ORs = 1.7 [95% CI = 0.9-3.4] and 0.6 [95% CI = 0.3-1.1]; respectively). Report of a palpable mass was associated with an increased risk of invasive cancer among women aged 30-49 years (OR = 12.0; 95% CI = 7.1-20.0); there was a trend in the same direction for DCIS (OR = 2.0; 95% CI = 0.8-5.1); but the association was much stronger for invasive disease than for DCIS (OR = 6.0; 95% CI = 2.1-18.0; P = .001). Among women aged 50 years and older; family history of breast cancer and nulliparity or age a | 8978410 | [
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Comparison of risk factors for ductal carcinoma in situ and invasive breast cancer. | t birth of first child of 30 years or older increased the risk of both DCIS (ORs = 2.2 [95% CI = 1.0-4.2] and 2.3 [95% CI = 1.3-3.8]; respectively) and invasive breast cancer (ORs = 1.5 [95% CI = 1.0-2.2] and 1.6 [95% CI = 1.2-2.1]; respectively). Report of a palpable mass was not associated with an increased risk of DCIS among women 50 years and older; but it was strongly associated with an increased risk of invasive cancer (OR = 9.3; 95% CI = 6.0-14.0). Increasing age was associated with an increased risk | 8978410 | [
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Comparison of risk factors for ductal carcinoma in situ and invasive breast cancer. | of both DCIS and invasive cancer among women aged 30-49 years; but the association was stronger for invasive disease; a trend in the same direction bordering on statistical significance was observed for women aged 50 years and older.Risk factors for DCIS are similar to those for invasive breast cancer.More research is needed to better understand the malignant potential of DCIS lesions and factors that predict which lesions will become invasive breast cancer if left untreated. | 8978410 | [
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Re: Severe neurotoxicity in vinorelbine-paclitaxel combinations. | nan | 8978412 | [
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Re: Smoking and colorectal cancer: a 20-year follow-up study of Swedish construction workers. | nan | 8978418 | [
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Re: B-cell non-Hodgkin's lymphoma: evidence for the t(14;18) translocation in all hematopoietic cell lineages. | nan | 8978417 | [
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Re: Stage IIIA category of non-small-cell lung cancer: a new proposal. | nan | 8978413 | [
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19th Annual San Antonio Breast Cancer Symposium. December 11-14, 1996. Abstracts. | nan | 8978421 | [
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Annual meeting of the American Academy for Cerebral Palsy and Developmental Medicine, 1993. Abstracts. | nan | 8978423 | [
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Advances in Ultrafast Computed Tomography: 1996. An International Symposium on Electron Beam Tomography. Lake Buena Vista, Florida, October 4-6, 1996. Abstracts. | nan | 8978420 | [
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7th International Conference on Chronopharmacology and Chronotherapeutics. Heidelberg, Germany, September 10-14, 1996. Abstracts. | nan | 8978422 | [
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VII World Meeting on Impotence. San Francisco, California, 3-7 November 1996. Abstracts. | nan | 8978425 | [
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British Diabetic Association's Education and Care Section Annual Conference 18-20 September 1996 and Medical and Scientific Section Autumn Meeting 19-20 September 1996, Exeter University. Abstracts. | nan | 8978424 | [
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The Physiological Society proceedings of the scientific meeting held at University College London, 16-18 April 1996. Abstracts. | nan | 8978426 | [
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[International Journal of Food Research and Technology]. | nan | 8978429 | [
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CHOQUE 96: 2nd Brazilian Shock Congress, SALT 7: 7th International Conference on Hypertonic Resuscitation. Sao Paulo, Brazil, 11-14 November 1996. Abstracts. | nan | 8978428 | [
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The Academy of Aphasia 34th annual meeting. London, England, November 3, 1996. Abstracts. | nan | 8978430 | [
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Intention as a component of the alpha-rhythm response to mental activity. | Many studies of alpha-rhythm reactivity conclude that alpha is selectively attenuated by attention accompanying mental activity. The topography of this attenuation is assumed to match the relevant functional topography of the cortex. But there are reports of apparent increased attention resulting in no change; or even enhanced alpha - the paradoxical response. It is proposed that in this case; alpha amplitude may be dependent on an intention component of behaviour. Some conflicting reports of alpha reactivi | 8978432 | [
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Intention as a component of the alpha-rhythm response to mental activity. | ty to mental processes may then be resolved. It is argued that the classical attention model of alpha is untenable; except for simple sensori-motor responses. Reasons are given to support this and the concept of intention as a neuropsychological variable is introduced. Evidence is presented for a generalisation of an oculomotor model of alpha activity proposed by Wertheim who demonstrated that alpha reduces during attentive; but not during intentive visual behaviour. The generalisation follows from reports | 8978432 | [
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Intention as a component of the alpha-rhythm response to mental activity. | of enhanced alpha in the few seconds prior to a skilled action in sport; and by neurophysiological evidence for a separate cortical organisation for perception and action. Varying proportions of attention and intention then add a dimension to the factors influencing alpha blocking which may explain its inconsistent response. | 8978432 | [
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Measurements by biphasic changes of the alpha band amplitude as indicators of arousal level. | The objective of this study was to develop a method of measuring arousal level by examining the change rates with activation of the alpha band amplitude using the concept of the inverted U-shaped pattern of transition of this amplitude. We investigated change rates by inspecting the electroencephalogram; and we evaluated their correlations with a criterion index of the arousal level (a reaction time measure); and other relevant basic parameters in 14 normal volunteers. In order to confirm that alpha band am | 8978433 | [
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Measurements by biphasic changes of the alpha band amplitude as indicators of arousal level. | plitude change followed an inverted U-shaped curve; we examined the transition of that index in a resting-and-relaxing condition. In the third session; the change rates upon stimulation and after resting had positive and negative correlations; respectively; with the reaction time measure; verifying that they are 'negative' and 'positive' arousal level indices. Further examinations were conducted for the third session. The change rates upon stimulation and after resting had negative correlations with each ot | 8978433 | [
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Measurements by biphasic changes of the alpha band amplitude as indicators of arousal level. | her. Neither of them had a significant correlation with the alpha band amplitude. Neither alpha band frequency; alpha band amplitude; or theta band amplitude; all of which are regarded as indices for intra-subject arousal level transition; had any significant correlation with the reaction time measure. These results revealed that the change rates of the alpha band amplitude are better indices for inter-individual arousal level variation than other conventional indices. | 8978433 | [
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Event-related synchronization (ERS) in the alpha band--an electrophysiological correlate of cortical idling: a review. | EEG desynchronization is a reliable correlate of excited neural structures of activated cortical areas. EEG synchronization within the alpha band may be an electrophysiological correlate of deactivated cortical areas. Such areas are not processing sensory information or motor output and can be considered to be in an idling state. One example of such an idling cortical area is the enhancement of mu rhythms in the primary hand area during visual processing or during foot movement. In both circumstances; the n | 8978434 | [
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Event-related synchronization (ERS) in the alpha band--an electrophysiological correlate of cortical idling: a review. | eurons in the hand area are not needed for visual processing or preparation for foot movement. As a result of this; an enhanced hand area mu rhythm can be observed. | 8978434 | [
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Event-related desynchronization (ERD) and the Dm effect: does alpha desynchronization during encoding predict later recall performance? | Based on previous research which has shown that event-related desynchronization (ERD) in the lower and upper alpha band reflects attentional and semantic processing respectively; the present study examines the hypothesis whether event-related shifts in the two alpha bands are capable of predicting later recall performance. In an incidental memory paradigm; subjects first had to judge the category membership for a set of 96 words. Later; without prior warning; subjects were asked to recall the words. The res | 8978435 | [
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Event-related desynchronization (ERD) and the Dm effect: does alpha desynchronization during encoding predict later recall performance? | ults show that for good performers; the extent of ERD in the lower alpha band during the semantic encoding for words is significantly larger for remembered as compared to not remembered words; whereas for bad performers the ERD in the upper alpha band is significantly more pronounced. This type of Dm effect is particularly strong over parietal recording sites in both hemispheres. In referring to the proposed interpretation of the lower and upper alpha band; the present findings seem to indicate that in cont | 8978435 | [
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Event-related desynchronization (ERD) and the Dm effect: does alpha desynchronization during encoding predict later recall performance? | rast to good performers; bad performers are less attentive or alert during encoding. Event-related potentials (ERPs) also yielded significant Dm effects at parietal recording sites. | 8978435 | [
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Gamma-band responses in the brain: a short review of psychophysiological correlates and functional significance. | The present study shows that gamma-band (40 Hz) activities exist in a number of brain structures of different species; with seemingly different functional/behavioral correlates. This rhythm has also different dynamics in various structures and under different experimental conditions: it exists spontaneously and/or can be evoked; induced or emitted with different latencies and relations to sensory-cognitive events. Recent measurements of gamma-band activity at the cellular level stress high level functional | 8978437 | [
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Gamma-band responses in the brain: a short review of psychophysiological correlates and functional significance. | correlates such as binding of features. In contrast; field potential measurements in both humans and animals demonstrate that gamma-band responses may have multifold functions both in 'obligatory' sensory and in cognitive processing. With respect to the generators of gamma activity; experimental data hint at the existence of a distributed gamma system in the brain. Furthermore; an interpretation of gamma rhythms as universal functional building blocks is suggested. | 8978437 | [
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Frontal gamma-band enhancement during multistable visual perception. | The aim of our study was to find out whether an increase in the gamma band may be related to the reversal phase during viewing of an ambiguous pattern. The present study describes the significant gamma band (30-50 Hz) activity increase in EEG during states of perceptual switching (reversal state). In our experiments the multistability was induced with an ambiguous stimulus pattern; known as stroboscopic alternative motion (SAM). The investigations carried out in 11 subjects included a measuring strategy wit | 8978438 | [
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Frontal gamma-band enhancement during multistable visual perception. | h three different experimental conditions: (1) recording of spontaneous EEG as baseline; (2) recording of the EEG during naive observation of the ambiguous pattern; (3) recording of EEG during active observation of SAM. The results indicate that the multistable perception is one of the multifold cognitive processes giving rise to 40 Hz enhancement in the entire cortex. The most significant 40 Hz enhancements were measured in frontal areas and can reach increases of 40 to 50% in states of naive and active ob | 8978438 | [
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Frontal gamma-band enhancement during multistable visual perception. | servations of SAM; respectively; in comparison to spontaneous EEG recordings. The results indicate that the increase of frontal gamma band is related to the destabilization of the perceptual system when viewing multistable patterns. | 8978438 | [
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Electrophysiological analysis of the registration, storage and retrieval of information in delayed matching from samples. | Brain processes of registration; storage in working memory and retrieval of different kinds of information were studied by analysis of EEG and ERP activity recorded during two delayed matches from sample tasks: (1) matching the digits in two series of six numbers; and (2) matching the sums of the same two series of six numbers. each trial was composed of six intervals continuing six equally spaced visual stimuli: (1) control--observing a series of six fixation points; P1; on a computer monitor; (2) priming- | 8978439 | [
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Electrophysiological analysis of the registration, storage and retrieval of information in delayed matching from samples. | -viewing a series; S1; of six numbers; (3) delay--observing a second series of six fixation points; P2; (4) matching--viewing a second series; S2; of six numbers; (5) response selection--selecting the left button to press if S1 contained all the items in S2 or the right button if any item appeared only in S2; while observing six fixation points; (6) feedback--six color coded fixation points indicate correct or error. Each interval was 4 s in duration and 20 trials were presented in each task. During each in | 8978439 | [
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Electrophysiological analysis of the registration, storage and retrieval of information in delayed matching from samples. | terval the visual field flickered at a tracer frequency of 1.5/s; whether numbers or fixation points were on the monitor screen. Very narrow band power spectra (VNB); ERPs elicited by presentation of S1 or S2 information items; and non-contingent probes (NCP) elicited by presentation of fixation points were used to trace the processing of information by neural populations activated by the visual stimulation. Global field power maxima identified latencies at which functional landscapes were analyzed. VNB; ER | 8978439 | [
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Electrophysiological analysis of the registration, storage and retrieval of information in delayed matching from samples. | P; NCP and landscape differences were found between digits and sums. However; though these differences were highly significant within each subject (p < 0.001); no consistency was found across individuals for the electrophysiological changes during the tasks. This suggests that utilization of brain resources in cognition varies greatly with individual cognitive styles and strategies. | 8978439 | [
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Approaches to verbal, visual and musical creativity by EEG coherence analysis. | Our approach to coherence analysis of the on-going EEG yields data on the cooperation between all possible electrode sites of the 10/20 system. This procedure compares epochs during mental activity with epochs of EEG at rest and takes into account only significant differences which are represented as lines between the respective electrodes on maps of the brain surface. The patterns thus obtained reflect the temporal average of the changes of the overall coherence pattern caused by any mental task. They are | 8978440 | [
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Approaches to verbal, visual and musical creativity by EEG coherence analysis. | interpreted as reflecting differential attention required for the achievement of the mental task in question. Acts of creative thinking; be it verbally; visually or musically; are characterized by more coherence increases between occipital and frontopolar electrode sites than any other mental tasks. The results are interpreted by a stronger involvement of long cortico-cortical fibre systems in creative tasks. | 8978440 | [
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Memory processes, brain oscillations and EEG synchronization. | This article tries to integrate results in memory research from divergent disciplines such as cognitive psychology; neuroanatomy; and neurophysiology. The integrating link is seen in more recent findings that provide strong arguments for the assumption that oscillations are a basic form of communication between cortical cell assemblies. It is assumed that synchronous oscillations of large cell assemblies--termed type 1 synchronization--reflect a resting state or possibly even a state of functional inhibitio | 8978436 | [
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Memory processes, brain oscillations and EEG synchronization. | n. On the other hand; during mental activity; when different neuronal networks may start to oscillate with different frequencies; each network may still oscillate synchronously (this is termed type 2 synchronization); but as a consequence; the large scale type 1 oscillation disappears. It is argued that these different types of synchronization can be observed in the scalp EEG by calculating event-related power changes within comparatively narrow but individually adjusted frequency bands. Experimental findin | 8978436 | [
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Memory processes, brain oscillations and EEG synchronization. | gs are discussed which support the hypothesis that short-term (episodic) memory demands lead to a synchronization (increase in band power) in the theta band; whereas long-term (semantic) memory demands lead to a task-specific desynchronization (decrease or suppression of power) in the upper alpha band. Based on these and other findings; a new memory model is proposed that is described on three levels: cognitive; anatomical and neurophysiological. It is suggested that short-term (episodic) memory processes a | 8978436 | [
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Memory processes, brain oscillations and EEG synchronization. | re reflected by oscillations in an anterior limbic system; whereas long-term (semantic) memory processes are reflected by oscillations in a posterior-thalamic system. Oscillations in these frequency bands possibly provide the basis for encoding; accessing; and retrieving cortical codes that are stored in the form of widely distributed but intensely interconnected cell assemblies. | 8978436 | [
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EEG delta activity: an indicator of attention to internal processing during performance of mental tasks. | In previous papers we proposed that an increase in delta EEG activity during mental tasks might be related to an increase in subjects' attention to internal processing. In this paper we have made a narrow band analysis to detect those EEG frequencies that change selectively during the performance of a mental task that requires attention to internal processing. Two different experiments were performed: (1) a difficult mental calculation task and a control stimulus with the same physical characteristics as th | 8978441 | [
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EEG delta activity: an indicator of attention to internal processing during performance of mental tasks. | e arithmetical symbols were presented in random order; (2) the Sternberg paradigm for the analysis of short term memory using a memory set of 5 or 3 digits was also presented in random order. Referential recordings to linked ears were obtained in all leads of the 10/20 system. In the first experiment; the increase of power from 1.56 to 5.46 Hz was observed only during the performance of the task and not during the control condition. In the Sternberg paradigm; the increase of power from 1.56 to 3.90 Hz was g | 8978441 | [
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EEG delta activity: an indicator of attention to internal processing during performance of mental tasks. | reater during the difficult than during the easy condition. These results support our hypothesis that an increase in delta activity may be related to attention to internal processing during the performance of a mental task. | 8978441 | [
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Working-memory load and dimensional complexity of the EEG. | This investigation shows that a working-memory load induced by a memory scanning task has an effect on nonlinear descriptors of the EEG dynamics. The effect was locally specific above the fronto-temporal (right) cortex and it may be described as a reduction in the dimensional complexity of cortical brain activity. The meaning of the effects seems to differ from that of EEG spectral power; which varied with time during the experiment and not with changes in the working-memory load conditions. Behaviorally co | 8978442 | [
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Working-memory load and dimensional complexity of the EEG. | ntrolled over- and underload led to increased variance of the dimensional complexity; thus indicating that dimensional complexity correlates more closely with actual performance than with more general descriptions of brain states. Habitual response speed had an effect at the parietal lead; thus indicating that fast responders reduced their dimensional complexity as the task demand increased. In contrast; the slower responders showed no such definite trend. | 8978442 | [
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Magnetic resonance in monitoring the natural history of multiple sclerosis and the effects of treatment. | In this review the main contributions of magnetic resonance (MR) techniques in the monitoring of multiple sclerosis (MS) course; both natural or modified by treatments; are presented. MR measures well correlate with short-term disease evolution and therefore their use is appropriate as primary end-points in preliminary clinical trials evaluating the effects of new treatments. In contrast; the correlation between MR measures and long-term clinical evolution in clinically definite MS is less clear; thus indic | 8978444 | [
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Magnetic resonance in monitoring the natural history of multiple sclerosis and the effects of treatment. | ating that such measures can be used at present only as a secondary end-point in large scale definitive trials. The results coming from the clinical application of newer MR techniques with higher pathological specificity are also presented and their possible future roles in monitoring treatment aimed at preventing development of disability in MS are discussed. | 8978444 | [
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Progressive multifocal leucoencephalopathy. | Progressive multifocal leucoencephalopathy (PML) is a rarely occurring demyelinating disease of the central nervous system caused by a neurotropic papovavirus named JC virus (JCV). The most frequently affected affected regions are the cerebral hemispheres; especially the parietooccipital region; followed by the cerebellum and brain stem. The disease occurs predominantly in individuals with an immunocompromised state and impaired cellular mediated immunity (CMI) due to other underlying illness. More extensiv | 8978445 | [
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Progressive multifocal leucoencephalopathy. | e use of irradiation and immunosuppressive therapy in relation to increased transplantational activities as well as treatment of autoimmune diseases and malignancies; in addition to the appearance of the acquired immunodeficiency syndrome (AIDS) as a consequence of infection with the human immunodeficiency virus (HIV); has caused a considerable increase in the occurrence of PML. The course of the disease is still most often rapidly progressive and fatal; but several cases with prolonged survival and even re | 8978445 | [
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Progressive multifocal leucoencephalopathy. | mission have been reported; and various antiviral treatments have been tried. The only drug that until now has shown favourable results is cytosine arabinoside. In HIV-infected PML-patients immunomodulation with AZT/zidovudine may alleviate the course and improve the prognosis in some patients. Suspicion of PML should lead to an extensive immunological investigation before considering of brain biopsy; which is still the only specific test. On the basis of the increased frequency of PML in relation to HIV-in | 8978445 | [
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Progressive multifocal leucoencephalopathy. | fection; it is likely that our knowledge of the pathogenetic aspects will increase; which; hopefully; may lead to an effective therapeutic strategy. | 8978445 | [
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Time of hospital presentation after stroke. A multicenter study in north-east Italy. Italian SINV (Società Interdisciplinare Neurovascolare) Study group. | Given the current orientation towards the early treatment of stroke; this multicenter study was carried out in North-east Italy in order to examine the times between stroke onset and hospital admission; and the possible factors leading to a lengthening of such times. An analysis was made of 348 patients; 79.8% of whom had experienced an ischemic cerebral infarct. Arrival times were not significantly modified by the distance from hospital; age; family cohabitation; socio-cultural level; population density or | 8978446 | [
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Time of hospital presentation after stroke. A multicenter study in north-east Italy. Italian SINV (Società Interdisciplinare Neurovascolare) Study group. | the geographical location of the Center. Sixty percent of the ischemic stroke cases arrived at the Emergency Department within three hours; and 80% within six hours; the hemorrhagic cases arrived earlier; 100% of them by the tenth hour. The duration of stay in the Emergency Department did not vary in relation to the severity or type of stroke. Greater severity; a reduced level of awareness and daytime onset led to a moderately significant reduction on presentation times. In conclusion; the majority of pati | 8978446 | [
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Time of hospital presentation after stroke. A multicenter study in north-east Italy. Italian SINV (Società Interdisciplinare Neurovascolare) Study group. | ents arrived sufficiently quickly to be treated within the "therapeutic window"; nevertheless; an information campaign may be useful in accelerating the hospital presentation of the albeit limited number of cases who arrive late. | 8978446 | [
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Cerebral venous thrombosis in young adults. Experience in a stroke unit, 1988-1994. | We report a series of nine patients younger than 45 years with angiographically-documented cerebral venous thrombosis; consecutively referred to our Stroke Unit from 1988 to 1994. Two of them were men and seven were women. Eight patients initially complained of headache; often associated with other symptoms of increased intracranial pressure. Seven patients had focal motor deficits and four suffered from epileptic seizures. None of the patients died. Only one patient remained severely disabled; whereas the | 8978448 | [
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