Datasets:
OTAR3088
/
BioData-CellLine_annotated

Dataset card Data Studio Files
xet
Community
1
PMCID
string
Sentences
string
ner
list
PMC11597291
Then, equimolar concentrations of 0.015 mmol EDC-HCl/NHS dissolved in 200 μL D-H2O were added dropwise.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Then", ",", "equimolar", "concentrations", "of", "0.015", "mmol", "EDC-HCl/NHS", "dissolved", "in", "200", "μL", "D-H2O", "were", "added", "dropwise", "." ] } ]
PMC11471157
Therefore, the measured amounts of aspartic acid include asparagine, and the measured amounts of glutamic acid include glutamine.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Therefore", ",", "the", "measured", "amounts", "of", "aspartic", "acid", "include", "asparagine", ",", "and", "the", "measured", "amounts", "of", "glutamic", "acid", "include", "glutamine", "." ] } ]
PMC11285179
Additionally, we evaluated the effect of retinoic acid on tumor cell viability using a CCK8 assay (Supplementary Fig. 4F).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Additionally", ",", "we", "evaluated", "the", "effect", "of", "retinoic", "acid", "on", "tumor", "cell", "viability", "using", "a", "CCK8", "assay", "(", "Supplementary", "Fig.", "4F", ")", "." ] } ]
PMC11687663
Distribution predictions consider factors influencing the compound’s distribution within the body.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Distribution", "predictions", "consider", "factors", "influencing", "the", "compound", "’s", "distribution", "within", "the", "body", "." ] } ]
PMC11583010
At the indicated time points, terminal blood sampling was performed, and plasma was prepared from naïve and PDX TNBC400 mice.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "At", "the", "indicated", "time", "points", ",", "terminal", "blood", "sampling", "was", "performed", ",", "and", "plasma", "was", "prepared", "from", "naïve", "and", "PDX", "TNBC400", "mice", "." ] } ]
PMC8409415
In A2780cisR and SKOV3cisR xenograft mice, the tumor weight on day 28 post‐administration (A2780cisR: 1260 vs 1340 mg, P = .75, SKVO3cisR: 531.7 vs 561.7 mg, P = .52) were similar in the cisplatin and PBS‐treated groups.
[ { "tags": [ "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "A2780cisR", "and", "SKOV3cisR", "xenograft", "mice", ",", "the", "tumor", "weight", "on", "day", "28", "post‐administration", "(", "A2780cisR", ":", "1260", "vs", "1340", "mg", ",", "P", "=", ".75", ",", "SKVO3cisR", ":", "531.7", "vs", "561.7", "mg", ",", "P", "=", ".52", ")", "were", "similar", "in", "the", "cisplatin", "and", "PBS‐treated", "groups", "." ] } ]
PMC11674441
To investigate the mechanism by which HLA class II-restricted neoantigen long peptides encompassing HLA class I-restricted epitope-pulsed DC vaccines elicited peripheral lymphocyte reactivity to both HLA class I and II neoantigen peptides, we examined the responses of CD8-positive T cells and CD4-positive T cells restimulated by mDCs + HLA class II-restricted neoantigen long peptide in BC5.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "investigate", "the", "mechanism", "by", "which", "HLA", "class", "II-restricted", "neoantigen", "long", "peptides", "encompassing", "HLA", "class", "I-restricted", "epitope-pulsed", "DC", "vaccines", "elicited", "peripheral", "lymphocyte", "reactivity", "to", "both", "HLA", "class", "I", "and", "II", "neoantigen", "peptides", ",", "we", "examined", "the", "responses", "of", "CD8-positive", "T", "cells", "and", "CD4-positive", "T", "cells", "restimulated", "by", "mDCs", "+", "HLA", "class", "II-restricted", "neoantigen", "long", "peptide", "in", "BC5", "." ] } ]
PMC11739504
Importantly, Kat2b depletion hampered the recruitment of IFT components to the cilium and decreased Hh signaling activation.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Importantly", ",", "Kat2b", "depletion", "hampered", "the", "recruitment", "of", "IFT", "components", "to", "the", "cilium", "and", "decreased", "Hh", "signaling", "activation", "." ] } ]
PMC9429973
SMZL-T had higher number of CNA than SMZL at diagnosis (8 vs 5; P<0.001).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "SMZL-T", "had", "higher", "number", "of", "CNA", "than", "SMZL", "at", "diagnosis", "(", "8", "vs", "5", ";", "P<0.001", ")", "." ] } ]
PMC10957991
TRPV4 and Piezo1 channels are known to mediate separate yet intersecting mechanosensitive pathways, suggesting that regulation of Piezo1 channel could further enhance the effect of TRPV4 depletion in bilayered mammary epithelium.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "TRPV4", "and", "Piezo1", "channels", "are", "known", "to", "mediate", "separate", "yet", "intersecting", "mechanosensitive", "pathways", ",", "suggesting", "that", "regulation", "of", "Piezo1", "channel", "could", "further", "enhance", "the", "effect", "of", "TRPV4", "depletion", "in", "bilayered", "mammary", "epithelium", "." ] } ]
PMC11640247
In vitro and in vivo experiments demonstrated that the p.R66W variant functions as an activated form of RAC3 and disrupts cortical development by impairing neuronal migration and axon elongation.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "vitro", "and", "in", "vivo", "experiments", "demonstrated", "that", "the", "p.", "R66W", "variant", "functions", "as", "an", "activated", "form", "of", "RAC3", "and", "disrupts", "cortical", "development", "by", "impairing", "neuronal", "migration", "and", "axon", "elongation", "." ] } ]
PMC11298021
These preliminary results highlight the potential for improving T-ALL treatment through multi-targeted therapeutic strategies involving rapamycin and miR-3143/miR-3182.T-cell acute lymphoblastic leukemia (T-ALL) diagnosis and treatment have made considerable strides, but those who have refractory or recurrent leukemia, still face negative side effects and poor prognosis.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "preliminary", "results", "highlight", "the", "potential", "for", "improving", "T-ALL", "treatment", "through", "multi-targeted", "therapeutic", "strategies", "involving", "rapamycin", "and", "miR-3143/miR-3182.T-cell", "acute", "lymphoblastic", "leukemia", "(", "T-ALL", ")", "diagnosis", "and", "treatment", "have", "made", "considerable", "strides", ",", "but", "those", "who", "have", "refractory", "or", "recurrent", "leukemia", ",", "still", "face", "negative", "side", "effects", "and", "poor", "prognosis", "." ] } ]
PMC11279397
In summary, Perilla frutescens shows promising potential as an antiviral drug candidate, highlighting the need for further preclinical studies and clinical trials.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "summary", ",", "Perilla", "frutescens", "shows", "promising", "potential", "as", "an", "antiviral", "drug", "candidate", ",", "highlighting", "the", "need", "for", "further", "preclinical", "studies", "and", "clinical", "trials", "." ] } ]
PMC11380329
GNPS online workflow was used to generate the molecular network .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "GNPS", "online", "workflow", "was", "used", "to", "generate", "the", "molecular", "network", "." ] } ]
PMC11045125
As shown in Fig 1B, ΔEBNA2 EBV-infected cells (grown on the feeder layer) express EBNA1 and LMP1, but not EBNA2 or EBNA3A, indicating the cells have “type II”-like viral latency (EBNA1+/EBNA2-neg, LMP1-pos).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "As", "shown", "in", "Fig", "1B", ",", "ΔEBNA2", "EBV-infected", "cells", "(", "grown", "on", "the", "feeder", "layer", ")", "express", "EBNA1", "and", "LMP1", ",", "but", "not", "EBNA2", "or", "EBNA3A", ",", "indicating", "the", "cells", "have", "“", "type", "II”-like", "viral", "latency", "(", "EBNA1+/EBNA2-neg", ",", "LMP1-pos", ")", "." ] } ]
PMC11767817
The plates were mixed on a plate shaker for 30 s at 300–500 rpm and incubated for 30 min in the dark.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "plates", "were", "mixed", "on", "a", "plate", "shaker", "for", "30", "s", "at", "300–500", "rpm", "and", "incubated", "for", "30", "min", "in", "the", "dark", "." ] } ]
PMC6617630
a–c WT-MYC (U2932), DHL (DOHH2), and THL (Val) were treated with JQ1 alone (5 μM), a sublethal dose of ABT-199 alone (500 nM), or a combination of both, and survival assay was performed by annexin/PI staining.
[ { "tags": [ "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "a", "–", "c", "WT-MYC", "(", "U2932", ")", ",", "DHL", "(", "DOHH2", ")", ",", "and", "THL", "(", "Val", ")", "were", "treated", "with", "JQ1", "alone", "(", "5", "μM", ")", ",", "a", "sublethal", "dose", "of", "ABT-199", "alone", "(", "500", "nM", ")", ",", "or", "a", "combination", "of", "both", ",", "and", "survival", "assay", "was", "performed", "by", "annexin/PI", "staining", "." ] } ]
PMC11755519
Based on an analysis of databases and cancer patient samples, Chen et al. focused on the lncRNA ELNAT1.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Based", "on", "an", "analysis", "of", "databases", "and", "cancer", "patient", "samples", ",", "Chen", "et", "al.", "focused", "on", "the", "lncRNA", "ELNAT1", "." ] } ]
PMC11533140
In particular, 17p presented strong inhibitory activity against PI3Kδ; significant isoform selectivity against PI3Kβ, PI3Kγ, and mTOR; acceptable safety profiles in normal cells, as well as in the Ames and hERG tests; and favorable pharmacokinetic properties.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "particular", ",", "17p", "presented", "strong", "inhibitory", "activity", "against", "PI3Kδ", ";", "significant", "isoform", "selectivity", "against", "PI3Kβ", ",", "PI3Kγ", ",", "and", "mTOR", ";", "acceptable", "safety", "profiles", "in", "normal", "cells", ",", "as", "well", "as", "in", "the", "Ames", "and", "hERG", "tests", ";", "and", "favorable", "pharmacokinetic", "properties", "." ] } ]
PMC11267830
b RNA-seq analysis of the propensity for various types of events following indisulam treatment.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "b", "RNA-seq", "analysis", "of", "the", "propensity", "for", "various", "types", "of", "events", "following", "indisulam", "treatment", "." ] } ]
PMC10040136
The precipitate was combined and washed twice in serum-free L-DMEM.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "precipitate", "was", "combined", "and", "washed", "twice", "in", "serum-free", "L-DMEM", "." ] } ]
PMC6190245
By increasing the time of incubation from 24 hr to 48 and 72 hr, at these concentrations, the synergistic effects decreased (Figure 3).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "By", "increasing", "the", "time", "of", "incubation", "from", "24", "hr", "to", "48", "and", "72", "hr", ",", "at", "these", "concentrations", ",", "the", "synergistic", "effects", "decreased", "(", "Figure", "3", ")", "." ] } ]
PMC9429973
This is associated with more aggressive disease and rates of AML transformation leading to dismal outcomes.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "is", "associated", "with", "more", "aggressive", "disease", "and", "rates", "of", "AML", "transformation", "leading", "to", "dismal", "outcomes", "." ] } ]
PMC11799978
Our findings provide a potential new mechanism for understanding the pH regulation in promoting antitumor immunity.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Our", "findings", "provide", "a", "potential", "new", "mechanism", "for", "understanding", "the", "pH", "regulation", "in", "promoting", "antitumor", "immunity", "." ] } ]
PMC11365983
D–F) In IMCD3 cells, Foxc1 knock-down and OE respectively reduce and increase cilia length; graphs depict fold change in cilia length and prevalence of short and long cilia (shRNA, OE: n = 1). (
[ { "tags": [ "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "D", "–", "F", ")", "In", "IMCD3", "cells", ",", "Foxc1", "knock-down", "and", "OE", "respectively", "reduce", "and", "increase", "cilia", "length", ";", "graphs", "depict", "fold", "change", "in", "cilia", "length", "and", "prevalence", "of", "short", "and", "long", "cilia", "(", "shRNA", ",", "OE", ":", "n", "=", "1", ")", ".", "(" ] } ]
PMC9429973
Pts with acquired MPNs were retrospectively classified according to the WHO 2016 criteria; pts with HIF mutations and/or anamnestic criteria of familial erythrocytosis were considered as FE, pts with MPLS505N, or MPLV501A mutations were defined as HT (Table1).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Pts", "with", "acquired", "MPNs", "were", "retrospectively", "classified", "according", "to", "the", "WHO", "2016", "criteria", ";", "pts", "with", "HIF", "mutations", "and/or", "anamnestic", "criteria", "of", "familial", "erythrocytosis", "were", "considered", "as", "FE", ",", "pts", "with", "MPLS505N", ",", "or", "MPLV501A", "mutations", "were", "defined", "as", "HT", "(", "Table1", ")", "." ] } ]
PMC10440586
During the five-year clinical monitoring, 12 patients had no recurrence were classified as non-recurrence patients, and 23 patients had recurrence were defined as relapse patients.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "During", "the", "five-year", "clinical", "monitoring", ",", "12", "patients", "had", "no", "recurrence", "were", "classified", "as", "non-recurrence", "patients", ",", "and", "23", "patients", "had", "recurrence", "were", "defined", "as", "relapse", "patients", "." ] } ]
PMC11612794
Scale bar, 10 μm.(G) Quantification data of GFP-Dsn1 signals at kinetochores in mitotic cells shown in (F).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Scale", "bar", ",", "10", "μm.(G", ")", "Quantification", "data", "of", "GFP-Dsn1", "signals", "at", "kinetochores", "in", "mitotic", "cells", "shown", "in", "(", "F", ")", "." ] } ]
PMC8584319
In the present study, we show that in the HepG2 hepatocellular carcinoma cell line, AZD8055-mediated translational inhibition is masked by ERK1/2 and p38 activation.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "the", "present", "study", ",", "we", "show", "that", "in", "the", "HepG2", "hepatocellular", "carcinoma", "cell", "line", ",", "AZD8055-mediated", "translational", "inhibition", "is", "masked", "by", "ERK1/2", "and", "p38", "activation", "." ] } ]
PMC11088135
B Dual luciferase reporter assay was performed to confirm the interaction between miR-376a-3p and YAP1. **
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "B", "Dual", "luciferase", "reporter", "assay", "was", "performed", "to", "confirm", "the", "interaction", "between", "miR-376a-3p", "and", "YAP1", ".", "*", "*" ] } ]
PMC9429973
We also detected daratumumab directly on the blasts by detecting its kappa chain on the blasts (patients 4).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "also", "detected", "daratumumab", "directly", "on", "the", "blasts", "by", "detecting", "its", "kappa", "chain", "on", "the", "blasts", "(", "patients", "4", ")", "." ] } ]
PMC10055960
A similar trend in the data that were obtained for the same compounds analyzed in the coordinating solvent (Figure 2) was observed.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "similar", "trend", "in", "the", "data", "that", "were", "obtained", "for", "the", "same", "compounds", "analyzed", "in", "the", "coordinating", "solvent", "(", "Figure", "2", ")", "was", "observed", "." ] } ]
PMC9429973
V. Otasevic, D. Antic, V. Vukovic, V. Djurasinovic, K. Tomic, B. Mihaljevic Lymphoma Center, Clinic for Hematology, University Clinical Center of Serbia; Faculty of Medicine, University of Belgrade, Belgrade, Serbia Background: Chronic lymphoproliferative disorder of natural killer (NK) cells (CLPD-NK) represents exceptionally rare and heterogeneous indolent disorder, which has various clinical manifestations.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "V.", "Otasevic", ",", "D.", "Antic", ",", "V.", "Vukovic", ",", "V.", "Djurasinovic", ",", "K.", "Tomic", ",", "B.", "Mihaljevic", "Lymphoma", "Center", ",", "Clinic", "for", "Hematology", ",", "University", "Clinical", "Center", "of", "Serbia", ";", "Faculty", "of", "Medicine", ",", "University", "of", "Belgrade", ",", "Belgrade", ",", "Serbia", "Background", ":", "Chronic", "lymphoproliferative", "disorder", "of", "natural", "killer", "(", "NK", ")", "cells", "(", "CLPD-NK", ")", "represents", "exceptionally", "rare", "and", "heterogeneous", "indolent", "disorder", ",", "which", "has", "various", "clinical", "manifestations", "." ] } ]
PMC6684588
Serum concentrations of creatine phosphokinase in wild-type and mdx mice treated i.m.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Serum", "concentrations", "of", "creatine", "phosphokinase", "in", "wild-type", "and", "mdx", "mice", "treated", "i.m", "." ] } ]
PMC9429973
The comparison with the core group of drugs outlines the following order of predicted P-gp affinity: (i) for VS protocol A: pro-SI306>pro-SI221>Nilotinib; (ii) for VS protocol B: pro-SI221>Lapatinib>pro-SI306>Tepotinib>Nilotinib.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "comparison", "with", "the", "core", "group", "of", "drugs", "outlines", "the", "following", "order", "of", "predicted", "P-gp", "affinity", ":", "(", "i", ")", "for", "VS", "protocol", "A", ":", "pro-SI306>pro-SI221>Nilotinib", ";", "(", "ii", ")", "for", "VS", "protocol", "B", ":", "pro-SI221>Lapatinib", ">", "pro-SI306>Tepotinib", ">", "Nilotinib", "." ] } ]
PMC11297139
The lysate was then sonicated and centrifuged.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "lysate", "was", "then", "sonicated", "and", "centrifuged", "." ] } ]
PMC11478724
U48 and GAPDH were used as internal housekeeping controls for hsa-MiR-320a and coding genes, respectively.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "U48", "and", "GAPDH", "were", "used", "as", "internal", "housekeeping", "controls", "for", "hsa-MiR-320a", "and", "coding", "genes", ",", "respectively", "." ] } ]
PMC11632064
Transcriptome libraries were generated using KAPA RNA HyperPrep (Roche) using poly-A selection (Thermo Fisher Scientific).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Transcriptome", "libraries", "were", "generated", "using", "KAPA", "RNA", "HyperPrep", "(", "Roche", ")", "using", "poly-A", "selection", "(", "Thermo", "Fisher", "Scientific", ")", "." ] } ]
PMC11093197
The media containing lentivirus were collected after 48 h of transfection, then passed through a 0.45‐μm filter, and concentrated with polyethylene glycol.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "media", "containing", "lentivirus", "were", "collected", "after", "48", "h", "of", "transfection", ",", "then", "passed", "through", "a", "0.45‐μm", "filter", ",", "and", "concentrated", "with", "polyethylene", "glycol", "." ] } ]
PMC11621565
A recent study showed that exposure to bacterial curli combined with fiber-deprived diet accelerate PD progression in a PD mouse model.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "recent", "study", "showed", "that", "exposure", "to", "bacterial", "curli", "combined", "with", "fiber-deprived", "diet", "accelerate", "PD", "progression", "in", "a", "PD", "mouse", "model", "." ] } ]
PMC11476837
Cells were seeded onto 96-well plates in the count of 10,000 cells per well.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cells", "were", "seeded", "onto", "96-well", "plates", "in", "the", "count", "of", "10,000", "cells", "per", "well", "." ] } ]
PMC11279397
Direct application of CA in the airways significantly rescued fatal influenza virus-induced pneumonia and reduced lung virus production in infected mice .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Direct", "application", "of", "CA", "in", "the", "airways", "significantly", "rescued", "fatal", "influenza", "virus-induced", "pneumonia", "and", "reduced", "lung", "virus", "production", "in", "infected", "mice", "." ] } ]
PMC9429973
Methods: A bulk analysis of DNA from separated malignant cells using comprehensive NGS panel LYNX (PMID 34082072) was performed on a representative CLL case at three time-points (TPs): at dg (TP1, month 0, Rai II), before first therapy (TP2, month 19) and during relapse (TP3, month 59).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Methods", ":", "A", "bulk", "analysis", "of", "DNA", "from", "separated", "malignant", "cells", "using", "comprehensive", "NGS", "panel", "LYNX", "(", "PMID", "34082072", ")", "was", "performed", "on", "a", "representative", "CLL", "case", "at", "three", "time-points", "(", "TPs", "):", "at", "dg", "(", "TP1", ",", "month", "0", ",", "Rai", "II", ")", ",", "before", "first", "therapy", "(", "TP2", ",", "month", "19", ")", "and", "during", "relapse", "(", "TP3", ",", "month", "59", ")", "." ] } ]
PMC9429973
Cell clusters were classified into five broad cell types -- IPs, HSPCs, NK/T cells, myeloid cells, and B-ALL cells (Figure C).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cell", "clusters", "were", "classified", "into", "five", "broad", "cell", "types", "--", "IPs", ",", "HSPCs", ",", "NK/T", "cells", ",", "myeloid", "cells", ",", "and", "B-ALL", "cells", "(", "Figure", "C", ")", "." ] } ]
PMC11734514
One-way ANOVA followed by Tukey’s post hoc test was performed.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "One-way", "ANOVA", "followed", "by", "Tukey", "’s", "post", "hoc", "test", "was", "performed", "." ] } ]
PMC11597291
The formulation was evaluated for its HN-1 targeting effect against oral squamous cell carcinoma (OSCC) in CAL-27 and SCC-25 cell lines, showing significant internalization and increased anticancer effect (DOX cytotoxicity).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "formulation", "was", "evaluated", "for", "its", "HN-1", "targeting", "effect", "against", "oral", "squamous", "cell", "carcinoma", "(", "OSCC", ")", "in", "CAL-27", "and", "SCC-25", "cell", "lines", ",", "showing", "significant", "internalization", "and", "increased", "anticancer", "effect", "(", "DOX", "cytotoxicity", ")", "." ] } ]
PMC11549612
Additionally, 5 normal kidney cell lines were also purchased and employed: HK-2, RPTEC/TERT1, HK-11, HEK 293, and LLC-PK1.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "B-CellLine", "O", "B-CellLine", "I-CellLine", "O", "O", "B-CellLine", "O" ], "tokens": [ "Additionally", ",", "5", "normal", "kidney", "cell", "lines", "were", "also", "purchased", "and", "employed", ":", "HK-2", ",", "RPTEC/TERT1", ",", "HK-11", ",", "HEK", "293", ",", "and", "LLC-PK1", "." ] } ]
PMC11684269
Mechanically, NAMPT enhanced aerobic glycolysis and mitochondrial respiration in CD4 T cells, thus enhancing its capacity to produce IFNγ.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Mechanically", ",", "NAMPT", "enhanced", "aerobic", "glycolysis", "and", "mitochondrial", "respiration", "in", "CD4", "T", "cells", ",", "thus", "enhancing", "its", "capacity", "to", "produce", "IFNγ", "." ] } ]
PMC10958426
Splited violin plot of coefficient of variation (CV) of gene expression level of detectable genes among cells in epithelial cells and epithelial subtypes compared with the same genes in cancer cells in patients.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Splited", "violin", "plot", "of", "coefficient", "of", "variation", "(", "CV", ")", "of", "gene", "expression", "level", "of", "detectable", "genes", "among", "cells", "in", "epithelial", "cells", "and", "epithelial", "subtypes", "compared", "with", "the", "same", "genes", "in", "cancer", "cells", "in", "patients", "." ] } ]
PMC10976516
Each of the different virus types has its own specific set of genes responsible for viral replication and in some cases immune evasion of the infected host cell.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Each", "of", "the", "different", "virus", "types", "has", "its", "own", "specific", "set", "of", "genes", "responsible", "for", "viral", "replication", "and", "in", "some", "cases", "immune", "evasion", "of", "the", "infected", "host", "cell", "." ] } ]
PMC11335267
A cut-off time of 21 min equivalent to a speed of 0.65 m/s was established.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "cut-off", "time", "of", "21", "min", "equivalent", "to", "a", "speed", "of", "0.65", "m/s", "was", "established", "." ] } ]
PMC11488203
Likewise, the second largest miR expression is represented by miR-132-3p (Fig. 4C) that acts as a tumor suppressor in a variety of solid tumors .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Likewise", ",", "the", "second", "largest", "miR", "expression", "is", "represented", "by", "miR-132", "-", "3p", "(", "Fig.", "4C", ")", "that", "acts", "as", "a", "tumor", "suppressor", "in", "a", "variety", "of", "solid", "tumors", "." ] } ]
PMC11412721
Whole-cell extracts were sonicated three times for 10 s and centrifuged at 13,000 r.p.m.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Whole-cell", "extracts", "were", "sonicated", "three", "times", "for", "10", "s", "and", "centrifuged", "at", "13,000", "r.p.m", "." ] } ]
PMC11683130
Psoriasis is a chronic inflammatory immune-mediated skin disease.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Psoriasis", "is", "a", "chronic", "inflammatory", "immune-mediated", "skin", "disease", "." ] } ]
PMC11295144
The data were plotted with Box-and-Whisker plots showing the median, standard deviation, and outliers.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "data", "were", "plotted", "with", "Box-and-Whisker", "plots", "showing", "the", "median", ",", "standard", "deviation", ",", "and", "outliers", "." ] } ]
PMC9429973
The administration of allogenic CAR-T did not increase the risk of viral infection or GVHD.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "administration", "of", "allogenic", "CAR-T", "did", "not", "increase", "the", "risk", "of", "viral", "infection", "or", "GVHD", "." ] } ]
PMC5417661
NOV202 was found to suppress cancer cell proliferation at low nanomolar concentrations (IC50 2.3–12.0 nM) and showed equal efficacy between OC cell line A2780 (IC50 2.4 nM) and its multidrug-resistant subline A2780/Adr (IC50 2.3 nM).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O" ], "tokens": [ "NOV202", "was", "found", "to", "suppress", "cancer", "cell", "proliferation", "at", "low", "nanomolar", "concentrations", "(", "IC50", "2.3–12.0", "nM", ")", "and", "showed", "equal", "efficacy", "between", "OC", "cell", "line", "A2780", "(", "IC50", "2.4", "nM", ")", "and", "its", "multidrug-resistant", "subline", "A2780/Adr", "(", "IC50", "2.3", "nM", ")", "." ] } ]
PMC11518702
Lower panel: for HGAL, in isoform B, Arg10 interestingly becomes converted to Ser10.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Lower", "panel", ":", "for", "HGAL", ",", "in", "isoform", "B", ",", "Arg10", "interestingly", "becomes", "converted", "to", "Ser10", "." ] } ]
PMC11768927
To counteract these barriers, researchers are exploring innovative strategies such as combining VSV with immune modulators, chemotherapy agents, and matrix-degrading enzymes to enhance viral replication and oncolytic activity in resistant tumors.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "counteract", "these", "barriers", ",", "researchers", "are", "exploring", "innovative", "strategies", "such", "as", "combining", "VSV", "with", "immune", "modulators", ",", "chemotherapy", "agents", ",", "and", "matrix-degrading", "enzymes", "to", "enhance", "viral", "replication", "and", "oncolytic", "activity", "in", "resistant", "tumors", "." ] } ]
PMC9429973
Regarding the evolution, 157 patients required treatment at any point during the evolution, 80% of patients with G1-2 FL and 89% of patients with G3A FL (p=0.26).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Regarding", "the", "evolution", ",", "157", "patients", "required", "treatment", "at", "any", "point", "during", "the", "evolution", ",", "80", "%", "of", "patients", "with", "G1", "-", "2", "FL", "and", "89", "%", "of", "patients", "with", "G3A", "FL", "(", "p=0.26", ")", "." ] } ]
PMC11547917
The extraction process to obtain bioactive substances are preferentially carried out using ethanol as an extraction solvent, given its high affinity for both lipophilic and hydrophilic bioactive molecules.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "extraction", "process", "to", "obtain", "bioactive", "substances", "are", "preferentially", "carried", "out", "using", "ethanol", "as", "an", "extraction", "solvent", ",", "given", "its", "high", "affinity", "for", "both", "lipophilic", "and", "hydrophilic", "bioactive", "molecules", "." ] } ]
PMC11607764
Notably, PTBP1’s role in RNA splicing opens up a new therapeutic target not addressed by most protein-focused traditional biomarkers.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Notably", ",", "PTBP1", "’s", "role", "in", "RNA", "splicing", "opens", "up", "a", "new", "therapeutic", "target", "not", "addressed", "by", "most", "protein-focused", "traditional", "biomarkers", "." ] } ]
PMC11659921
Data from the Gene Set Cancer Analysis (GSCA, http://bioinfo.life.hust.edu.cn/GSCA/#/) were used to evaluate the occurrence of gene mutations linked to angiogenesis and stemness.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Data", "from", "the", "Gene", "Set", "Cancer", "Analysis", "(", "GSCA", ",", "http://bioinfo.life.hust.edu.cn/GSCA/#/", ")", "were", "used", "to", "evaluate", "the", "occurrence", "of", "gene", "mutations", "linked", "to", "angiogenesis", "and", "stemness", "." ] } ]
PMC11683240
In our in vivo studies mice were administered with human α1AT at a concentration of 10 mg/ml, with each mouse receiving volumes corresponding to a dose of 50 mg/kg of mouse weight.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "our", "in", "vivo", "studies", "mice", "were", "administered", "with", "human", "α1AT", "at", "a", "concentration", "of", "10", "mg/ml", ",", "with", "each", "mouse", "receiving", "volumes", "corresponding", "to", "a", "dose", "of", "50", "mg/kg", "of", "mouse", "weight", "." ] } ]
PMC5025404
Reseeding was performed every 3–4 days to a density of 0.3–0.5 × 10 cells/mL. We used CD DG-44 (Life technologies, USA) and PowerCHO 2CD (Lonza, Switzerland) serum-free media supplemented with 8 mM L-glutamin.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Reseeding", "was", "performed", "every", "3–4", "days", "to", "a", "density", "of", "0.3–0.5", "×", "10", "cells/mL.", "We", "used", "CD", "DG-44", "(", "Life", "technologies", ",", "USA", ")", "and", "PowerCHO", "2CD", "(", "Lonza", ",", "Switzerland", ")", "serum-free", "media", "supplemented", "with", "8", "mM", "L-glutamin", "." ] } ]
PMC8414691
P < 0.05; **P < 0.005; and ***P < 0.0005 compared with the controls group (mock and scramble) by Fisher’s exact testTable 1Cell division defects found in SRCAP depleted HeLa cellsControlRNAiMock (%)Scramble (%)SRCAP A (%)SRCAP B (%)MetaphaseMS4.38 ± 2.5806.21 ± 4.43***(scramble)0CM15.31 ± 14.453.30 ± 5.8057.36 ± 16.78***47.90 ± 5.90***ASM2.25 ± 0.45029.93 ± 2.80***20.8 ± 5.90***TelophaseCB6.00 ± 1.971.00 ± 1.708.45 ± 4.96*(mock), ***(scramble)38.20 ± 3.60***LIB1.87 ± 0.678.10 ± 1.1028.69 ± 9.21**23.80 ± 3.60***MC2.16 ± 0.491.90 ± 1.7014.21 ± 3.74***9.30 ± 2.30***CB, chromatin bridges; CM, chromosome misalignments; LIB, long intercellular bridges; MC, multinucleated cells; MS, multipolar SpindlesThe results are expressed as mean ± SD values from three independent replicate experiments: *P < 0.05; **P < 0.005; and ***P < 0.0005 compared with the controls group by Fisher’s exact testNotably, MS found in cells treated with SRCAP A are statistically significant (***) compared to scramble, but not to mock.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "P", "<", "0.05", ";", "*", "*", "P", "<", "0.005", ";", "and", "*", "*", "*", "P", "<", "0.0005", "compared", "with", "the", "controls", "group", "(", "mock", "and", "scramble", ")", "by", "Fisher", "’s", "exact", "testTable", "1Cell", "division", "defects", "found", "in", "SRCAP", "depleted", "HeLa", "cellsControlRNAiMock", "(%)Scramble", "(%)SRCAP", "A", "(%)SRCAP", "B", "(%)MetaphaseMS4.38", "±", "2.5806.21", "±", "4.43***(scramble)0CM15.31", "±", "14.453.30", "±", "5.8057.36", "±", "16.78***47.90", "±", "5.90***ASM2.25", "±", "0.45029.93", "±", "2.80***20.8", "±", "5.90***TelophaseCB6.00", "±", "1.971.00", "±", "1.708.45", "±", "4.96*(mock", ")", ",", "*", "*", "*", "(scramble)38.20", "±", "3.60***LIB1.87", "±", "0.678.10", "±", "1.1028.69", "±", "9.21**23.80", "±", "3.60***MC2.16", "±", "0.491.90", "±", "1.7014.21", "±", "3.74***9.30", "±", "2.30***CB", ",", "chromatin", "bridges", ";", "CM", ",", "chromosome", "misalignments", ";", "LIB", ",", "long", "intercellular", "bridges", ";", "MC", ",", "multinucleated", "cells", ";", "MS", ",", "multipolar", "SpindlesThe", "results", "are", "expressed", "as", "mean", "±", "SD", "values", "from", "three", "independent", "replicate", "experiments", ":", "*", "P", "<", "0.05", ";", "*", "*", "P", "<", "0.005", ";", "and", "*", "*", "*", "P", "<", "0.0005", "compared", "with", "the", "controls", "group", "by", "Fisher", "’s", "exact", "testNotably", ",", "MS", "found", "in", "cells", "treated", "with", "SRCAP", "A", "are", "statistically", "significant", "(", "*", "*", "*", ")", "compared", "to", "scramble", ",", "but", "not", "to", "mock", "." ] } ]
PMC11122631
resulted in the isolation and characterization of thirteen marine prostanoids, including two new ones.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "resulted", "in", "the", "isolation", "and", "characterization", "of", "thirteen", "marine", "prostanoids", ",", "including", "two", "new", "ones", "." ] } ]
PMC4270159
Treat cells with 29 ng/ml HGF for 10 min at 37°C.iii.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Treat", "cells", "with", "29", "ng/ml", "HGF", "for", "10", "min", "at", "37", "°", "C.iii", "." ] } ]
PMC11725127
G, H) Levels of KRAS in MM.1S (G) and RPMI 8226 (H) cells treated with 1 μmol/L GA for 24 h in the presence or absence of MG132 (20 μmol/L), which was added 6 h before the cells were harvested. (
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "G", ",", "H", ")", "Levels", "of", "KRAS", "in", "MM.1S", "(", "G", ")", "and", "RPMI", "8226", "(", "H", ")", "cells", "treated", "with", "1", "μmol/L", "GA", "for", "24", "h", "in", "the", "presence", "or", "absence", "of", "MG132", "(", "20", "μmol/L", ")", ",", "which", "was", "added", "6", "h", "before", "the", "cells", "were", "harvested", ".", "(" ] } ]
PMC11240571
After 48 h of incubation, the conditioned medium was collected and centrifuged at 3000× g for 15 min at 4 °C to thoroughly remove cellular debris.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "48", "h", "of", "incubation", ",", "the", "conditioned", "medium", "was", "collected", "and", "centrifuged", "at", "3000", "×", "g", "for", "15", "min", "at", "4", "°", "C", "to", "thoroughly", "remove", "cellular", "debris", "." ] } ]
PMC11585994
Flow cytometry data were analyzed using FlowJo 10.8 software.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Flow", "cytometry", "data", "were", "analyzed", "using", "FlowJo", "10.8", "software", "." ] } ]
PMC11401350
Since Tfh CD4 + lymphoma cells are not detectable in the blood, recipient mice were sacrificed week 6, 8 and 12 upon tumor cell injection to determine the timepoint of efficient lymphoma engraftment.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Since", "Tfh", "CD4", "+", "lymphoma", "cells", "are", "not", "detectable", "in", "the", "blood", ",", "recipient", "mice", "were", "sacrificed", "week", "6", ",", "8", "and", "12", "upon", "tumor", "cell", "injection", "to", "determine", "the", "timepoint", "of", "efficient", "lymphoma", "engraftment", "." ] } ]
PMC9429973
Summary/Conclusion: In summary, our analysis demonstrated that azacitidine and venetoclax show high response rates and improved OS amongst patients who responded to treatment.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Summary/Conclusion", ":", "In", "summary", ",", "our", "analysis", "demonstrated", "that", "azacitidine", "and", "venetoclax", "show", "high", "response", "rates", "and", "improved", "OS", "amongst", "patients", "who", "responded", "to", "treatment", "." ] } ]
PMC11753949
In this work we show that wild-type synaptopodin not only can crosslink and bundle actin, as previously reported, but can also connect actin bundles to the ER in living cells, both in neurons and in non-neuronal cells.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "this", "work", "we", "show", "that", "wild-type", "synaptopodin", "not", "only", "can", "crosslink", "and", "bundle", "actin", ",", "as", "previously", "reported", ",", "but", "can", "also", "connect", "actin", "bundles", "to", "the", "ER", "in", "living", "cells", ",", "both", "in", "neurons", "and", "in", "non-neuronal", "cells", "." ] } ]
PMC9429973
Median Hb level at EOC12 was 9.3 g/dL; 15/39 pts (38%) were on treatment for >30 cycles, and 3 pts remained on long-term treatment (cycle 76, 97, and 98).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Median", "Hb", "level", "at", "EOC12", "was", "9.3", "g/dL", ";", "15/39", "pts", "(", "38", "%", ")", "were", "on", "treatment", "for", ">", "30", "cycles", ",", "and", "3", "pts", "remained", "on", "long-term", "treatment", "(", "cycle", "76", ",", "97", ",", "and", "98", ")", "." ] } ]
PMC11637276
Here, we developed a high-content screening assay to study ECM uptake, based on the of use automated ECM coating for the generation of highly homogeneous ECM a pH-sensitive dye to image ECM trafficking in live cells.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Here", ",", "we", "developed", "a", "high-content", "screening", "assay", "to", "study", "ECM", "uptake", ",", "based", "on", "the", "of", "use", "automated", "ECM", "coating", "for", "the", "generation", "of", "highly", "homogeneous", "ECM", "a", "pH-sensitive", "dye", "to", "image", "ECM", "trafficking", "in", "live", "cells", "." ] } ]
PMC11394112
Although VAL cells show the constitutive activation of STAT3 as indicated by the presence of pSTAT3 in untreated cells, IL6 promotes additional STAT3 activation by ~6-fold after 30 min and to a lesser extent after 1 h. Previous work linked the expression of the IL6 receptor (IL6R) α subunit (IL6Rα) and gp130, the signaling chain subunit of the IL6R, to IL6-mediated STAT3 activation in DLBCL .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Although", "VAL", "cells", "show", "the", "constitutive", "activation", "of", "STAT3", "as", "indicated", "by", "the", "presence", "of", "pSTAT3", "in", "untreated", "cells", ",", "IL6", "promotes", "additional", "STAT3", "activation", "by", "~6-fold", "after", "30", "min", "and", "to", "a", "lesser", "extent", "after", "1", "h.", "Previous", "work", "linked", "the", "expression", "of", "the", "IL6", "receptor", "(", "IL6R", ")", "α", "subunit", "(", "IL6Rα", ")", "and", "gp130", ",", "the", "signaling", "chain", "subunit", "of", "the", "IL6R", ",", "to", "IL6-mediated", "STAT3", "activation", "in", "DLBCL", "." ] } ]
PMC10777969
Here, we show that two novel heterocyclic moieties linked to functionalized carbohydrate with an anhydro scaffold skeleton caused the death of the investigated cancer cells.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Here", ",", "we", "show", "that", "two", "novel", "heterocyclic", "moieties", "linked", "to", "functionalized", "carbohydrate", "with", "an", "anhydro", "scaffold", "skeleton", "caused", "the", "death", "of", "the", "investigated", "cancer", "cells", "." ] } ]
PMC9046263
DDX25 is a member of the DEAD-box protein family and is required for RNA processing/export, transcription, and translation initiation.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "DDX25", "is", "a", "member", "of", "the", "DEAD-box", "protein", "family", "and", "is", "required", "for", "RNA", "processing/export", ",", "transcription", ",", "and", "translation", "initiation", "." ] } ]
PMC8358006
d Cumulative distribution of gene expression changes in TCGA ESCC.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "d", "Cumulative", "distribution", "of", "gene", "expression", "changes", "in", "TCGA", "ESCC", "." ] } ]
PMC10810426
Equal amounts of virus, normalized by RNA levels, were also analyzed by Western blots (S9 Fig).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Equal", "amounts", "of", "virus", ",", "normalized", "by", "RNA", "levels", ",", "were", "also", "analyzed", "by", "Western", "blots", "(", "S9", "Fig", ")", "." ] } ]
PMC9739791
prodrug reduction was confirmed by H NMR by the disappearance of triplet peaks at 2.3 and 2.55 ppm and the appearance of a singlet peak at 2.35 ppm corresponding to free succinic acid.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "prodrug", "reduction", "was", "confirmed", "by", "H", "NMR", "by", "the", "disappearance", "of", "triplet", "peaks", "at", "2.3", "and", "2.55", "ppm", "and", "the", "appearance", "of", "a", "singlet", "peak", "at", "2.35", "ppm", "corresponding", "to", "free", "succinic", "acid", "." ] } ]
PMC11026382
As our initial model was developed using only two extreme TYMS variants (wild-type and a near complete loss of function variant, R166Q), we were particularly curious to evaluate model performance for TYMS mutations with intermediate effects on catalysis and E. coli growth.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "As", "our", "initial", "model", "was", "developed", "using", "only", "two", "extreme", "TYMS", "variants", "(", "wild-type", "and", "a", "near", "complete", "loss", "of", "function", "variant", ",", "R166Q", ")", ",", "we", "were", "particularly", "curious", "to", "evaluate", "model", "performance", "for", "TYMS", "mutations", "with", "intermediate", "effects", "on", "catalysis", "and", "E.", "coli", "growth", "." ] } ]
PMC7369657
Reactive oxygen species (ROS) were detected by the oxidation-sensitive fluorescent probe 2′,7′-dichlorofluorescein diacetate (DCFH-DA, Beyotime, Shanghai, China).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Reactive", "oxygen", "species", "(", "ROS", ")", "were", "detected", "by", "the", "oxidation-sensitive", "fluorescent", "probe", "2′,7′-dichlorofluorescein", "diacetate", "(", "DCFH-DA", ",", "Beyotime", ",", "Shanghai", ",", "China", ")", "." ] } ]
PMC7868205
Various modes of exposure can lead to size, dose and encapsulation-dependent cellular uptake of AgNPs.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Various", "modes", "of", "exposure", "can", "lead", "to", "size", ",", "dose", "and", "encapsulation-dependent", "cellular", "uptake", "of", "AgNPs", "." ] } ]
PMC11733919
Thus, iron accumulation may play a complex role during ferroptosis depending on the cellular context.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Thus", ",", "iron", "accumulation", "may", "play", "a", "complex", "role", "during", "ferroptosis", "depending", "on", "the", "cellular", "context", "." ] } ]
PMC9429973
A logistic multivariable regression analysis of the effects of prognostic BL covariates on LTS was performed.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "logistic", "multivariable", "regression", "analysis", "of", "the", "effects", "of", "prognostic", "BL", "covariates", "on", "LTS", "was", "performed", "." ] } ]
PMC9429973
In patients with the debut of ALL, mortality was 45% (9 patients), in relapse and refractory course - 50% (5 patients) (p=0.005).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "patients", "with", "the", "debut", "of", "ALL", ",", "mortality", "was", "45", "%", "(", "9", "patients", ")", ",", "in", "relapse", "and", "refractory", "course", "-", "50", "%", "(", "5", "patients", ")", "(", "p=0.005", ")", "." ] } ]
PMC9684669
Terfenadine overcomes MDR in ovarian cancer cells by inhibiting the CAMK2/CREB-mediated pathway. (
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Terfenadine", "overcomes", "MDR", "in", "ovarian", "cancer", "cells", "by", "inhibiting", "the", "CAMK2/CREB-mediated", "pathway", ".", "(" ] } ]
PMC8658661
Hepatocytes are rich in the smooth endoplasmic reticulum (SER) and mitochondria, reflecting their intense protein synthesis and energy metabolism, respectively .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Hepatocytes", "are", "rich", "in", "the", "smooth", "endoplasmic", "reticulum", "(", "SER", ")", "and", "mitochondria", ",", "reflecting", "their", "intense", "protein", "synthesis", "and", "energy", "metabolism", ",", "respectively", "." ] } ]
PMC11721277
The RHT after purification was less than 1% for all labeling conditions tested.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "RHT", "after", "purification", "was", "less", "than", "1", "%", "for", "all", "labeling", "conditions", "tested", "." ] } ]
PMC10125312
Temperature dynamics in +AuNR-PEG and ⌀AuNR cells upon irradiation. (
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Temperature", "dynamics", "in", "+", "AuNR-PEG", "and", "⌀", "AuNR", "cells", "upon", "irradiation", ".", "(" ] } ]
PMC9611901
It enables detection of primary DNA damage at the level of an individual cell, inflicted by direct action of various chemical (or physical) agents or by indirect action of free radicals (for example, reactive oxygen species).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "enables", "detection", "of", "primary", "DNA", "damage", "at", "the", "level", "of", "an", "individual", "cell", ",", "inflicted", "by", "direct", "action", "of", "various", "chemical", "(", "or", "physical", ")", "agents", "or", "by", "indirect", "action", "of", "free", "radicals", "(", "for", "example", ",", "reactive", "oxygen", "species", ")", "." ] } ]
PMC11806182
Our findings suggest that aberrant miRNA expression, particularly miR-330 and miR-424, may play crucial roles in UCEC progression.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Our", "findings", "suggest", "that", "aberrant", "miRNA", "expression", ",", "particularly", "miR-330", "and", "miR-424", ",", "may", "play", "crucial", "roles", "in", "UCEC", "progression", "." ] } ]
PMC9429973
Calcium mobilization in response to CXCL12 was enhanced in cells harboring the R334X mutation, reaching a 2.5- to 3-fold higher maximum effect (Emax) compared to cells with WT CXCR4.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Calcium", "mobilization", "in", "response", "to", "CXCL12", "was", "enhanced", "in", "cells", "harboring", "the", "R334X", "mutation", ",", "reaching", "a", "2.5-", "to", "3-fold", "higher", "maximum", "effect", "(", "Emax", ")", "compared", "to", "cells", "with", "WT", "CXCR4", "." ] } ]
PMC11499381
of at least three independent experiments performed in duplicate or triplicate, for exact n numbers see Table 1.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "of", "at", "least", "three", "independent", "experiments", "performed", "in", "duplicate", "or", "triplicate", ",", "for", "exact", "n", "numbers", "see", "Table", "1", "." ] } ]
PMC10606998
The most aggressive and common among them is glioblastoma (adult-type diffuse glioma, IDH-wild, CNS WHO grade IV in accordance with the 2021 World Health Organization Classification of Tumors of the Central Nervous System) .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "most", "aggressive", "and", "common", "among", "them", "is", "glioblastoma", "(", "adult-type", "diffuse", "glioma", ",", "IDH-wild", ",", "CNS", "WHO", "grade", "IV", "in", "accordance", "with", "the", "2021", "World", "Health", "Organization", "Classification", "of", "Tumors", "of", "the", "Central", "Nervous", "System", ")", "." ] } ]
PMC11721277
Found: 1013.4171.
[ { "tags": [ "O", "O", "O", "O" ], "tokens": [ "Found", ":", "1013.4171", "." ] } ]
PMC9429973
Specifically, the strength of recommendations was determined by the balance between desirable and undesirable consequences of alternative management strategies, quality of evidence, variability in values, preferences, and resource used.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Specifically", ",", "the", "strength", "of", "recommendations", "was", "determined", "by", "the", "balance", "between", "desirable", "and", "undesirable", "consequences", "of", "alternative", "management", "strategies", ",", "quality", "of", "evidence", ",", "variability", "in", "values", ",", "preferences", ",", "and", "resource", "used", "." ] } ]
PMC11337594
The Puro-containing medium was changed every 2–3 days, and the control cells were replaced with fresh medium immediately after complete cell death was observed.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "Puro-containing", "medium", "was", "changed", "every", "2–3", "days", ",", "and", "the", "control", "cells", "were", "replaced", "with", "fresh", "medium", "immediately", "after", "complete", "cell", "death", "was", "observed", "." ] } ]