OTAR3088/BioData-CellLine_annotated · Datasets at Hugging Face

PMCID string	Sentences string	ner list
PMC8922418	Thus, this crRNA library may serve as a preventive treatment against future pathogenic coronaviruses that evolved to escape immune surveillance (Abbott et al., 2020).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Thus", ",", "this", "crRNA", "library", "may", "serve", "as", "a", "preventive", "treatment", "against", "future", "pathogenic", "coronaviruses", "that", "evolved", "to", "escape", "immune", "surveillance", "(", "Abbott", "et", "al.", ",", "2020", ")", "." ] } ]
PMC11765988	MicroRNAs may be linked to various forms of lymphoma and sarcoidosis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "MicroRNAs", "may", "be", "linked", "to", "various", "forms", "of", "lymphoma", "and", "sarcoidosis", "." ] } ]
PMC9954564	Among the SNPs significantly associated with the dominant model (Table 2), rs6932888 and rs6932596 are in strong LD with each other (r ≥ 0.90).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Among", "the", "SNPs", "significantly", "associated", "with", "the", "dominant", "model", "(", "Table", "2", ")", ",", "rs6932888", "and", "rs6932596", "are", "in", "strong", "LD", "with", "each", "other", "(", "r", "≥", "0.90", ")", "." ] } ]
PMC11026382	This means that these DHFR mutations are more deleterious in the background of TYMS Q33S than in the native TYMS context.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "means", "that", "these", "DHFR", "mutations", "are", "more", "deleterious", "in", "the", "background", "of", "TYMS", "Q33S", "than", "in", "the", "native", "TYMS", "context", "." ] } ]
PMC9429973	Key words: hemophilia A, pharmacokinetics, children, one-chamber model, non-av-model H. Patel, S. Peltier, K. Clark, M. T. Reding Bio Products Laboratory Ltd. UK, Elstree, United Kingdom; University of Minnesota Medical Center, Minneapolis; Bio Products Laboratory USA, Inc., Durham, United States of America Background: Coagulation factor X, human is a plasma-derived factor X concentrate indicated to treat and prevent bleeding in individuals with hereditary factor X deficiency (HFXD).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Key", "words", ":", "hemophilia", "A", ",", "pharmacokinetics", ",", "children", ",", "one-chamber", "model", ",", "non-av-model", "H.", "Patel", ",", "S.", "Peltier", ",", "K.", "Clark", ",", "M.", "T.", "Reding", "Bio", "Products", "Laboratory", "Ltd.", "UK", ",", "Elstree", ",", "United", "Kingdom", ";", "University", "of", "Minnesota", "Medical", "Center", ",", "Minneapolis", ";", "Bio", "Products", "Laboratory", "USA", ",", "Inc.", ",", "Durham", ",", "United", "States", "of", "America", "Background", ":", "Coagulation", "factor", "X", ",", "human", "is", "a", "plasma-derived", "factor", "X", "concentrate", "indicated", "to", "treat", "and", "prevent", "bleeding", "in", "individuals", "with", "hereditary", "factor", "X", "deficiency", "(", "HFXD", ")", "." ] } ]
PMC9684669	CAMK2D’s apparent aggregation temperature (Tagg) was evaluated in the absence or presence of terfenadine in A2780-ADR cell lysates ( Figure 5F and Figure S6C ).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "CAMK2D", "’s", "apparent", "aggregation", "temperature", "(", "Tagg", ")", "was", "evaluated", "in", "the", "absence", "or", "presence", "of", "terfenadine", "in", "A2780-ADR", "cell", "lysates", "(", "Figure", "5F", "and", "Figure", "S6C", ")", "." ] } ]
PMC7823217	The potential precursor of cervical cancer is cervical intraepithelial neoplasia.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "potential", "precursor", "of", "cervical", "cancer", "is", "cervical", "intraepithelial", "neoplasia", "." ] } ]
PMC9429973	The median age was 60 years (range 19-89) and 96 (59%) were female.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "median", "age", "was", "60", "years", "(", "range", "19", "-", "89", ")", "and", "96", "(", "59", "%", ")", "were", "female", "." ] } ]
PMC10723784	Previous studies have also reported the induction of apoptosis by CBD in breast, prostate, glioma, and colon cancers, whereas CBG‐induced apoptosis was observed in prostate and colon cancers. , , ,	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Previous", "studies", "have", "also", "reported", "the", "induction", "of", "apoptosis", "by", "CBD", "in", "breast", ",", "prostate", ",", "glioma", ",", "and", "colon", "cancers", ",", "whereas", "CBG‐induced", "apoptosis", "was", "observed", "in", "prostate", "and", "colon", "cancers", ".", ",", ",", "," ] } ]
PMC11679892	After removing the PBS, 500 μL Trizol was added to the wells to lift the cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "removing", "the", "PBS", ",", "500", "μL", "Trizol", "was", "added", "to", "the", "wells", "to", "lift", "the", "cells", "." ] } ]
PMC10988555	Figure S17 demonstrates that complexes 2–4 interact with CT-DNA and by increasing its concentration an effect in the lowest-energy absorption band is observed, namely, a small hyperchromic effect for complex 2 and a hypochromic effect for 3 and 4, with no major shifts on the bands.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Figure", "S17", "demonstrates", "that", "complexes", "2–4", "interact", "with", "CT-DNA", "and", "by", "increasing", "its", "concentration", "an", "effect", "in", "the", "lowest-energy", "absorption", "band", "is", "observed", ",", "namely", ",", "a", "small", "hyperchromic", "effect", "for", "complex", "2", "and", "a", "hypochromic", "effect", "for", "3", "and", "4", ",", "with", "no", "major", "shifts", "on", "the", "bands", "." ] } ]
PMC7153288	Values were represented as mean ± SD (n = 3).Fig.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Values", "were", "represented", "as", "mean", "±", "SD", "(", "n", "=", "3).Fig", "." ] } ]
PMC11321678	Therefore, understanding the internal regulatory program and complex cell‐cell interaction of MB will greatly expand the range of therapeutic approaches.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Therefore", ",", "understanding", "the", "internal", "regulatory", "program", "and", "complex", "cell‐cell", "interaction", "of", "MB", "will", "greatly", "expand", "the", "range", "of", "therapeutic", "approaches", "." ] } ]
PMC11457557	In 2018, the FTO gene locus showed an association with DKD (SNP rs56094641) (P = 7.7 × 10 − 10) in GWAS of Japanese individuals with T2DM.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "2018", ",", "the", "FTO", "gene", "locus", "showed", "an", "association", "with", "DKD", "(", "SNP", "rs56094641", ")", "(", "P", "=", "7.7", "×", "10", "−", "10", ")", "in", "GWAS", "of", "Japanese", "individuals", "with", "T2DM", "." ] } ]
PMC11391695	HCC cells were incubated in 48-well plates containing 100 µL of EdU working solution for a duration of 2 h. The cells were then immersed for 15 min in a 4% solution of paraformaldehyde before being encapsulated in a PBS solution supplemented with 3% bovine serum albumin (BSA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "HCC", "cells", "were", "incubated", "in", "48-well", "plates", "containing", "100", "µL", "of", "EdU", "working", "solution", "for", "a", "duration", "of", "2", "h.", "The", "cells", "were", "then", "immersed", "for", "15", "min", "in", "a", "4", "%", "solution", "of", "paraformaldehyde", "before", "being", "encapsulated", "in", "a", "PBS", "solution", "supplemented", "with", "3", "%", "bovine", "serum", "albumin", "(", "BSA", ")", "." ] } ]
PMC7685376	In MF analysis, differentially expressed proteins were mainly enriched in organic cyclic compound binding (20%), oxygen binding (19%), protein binding (19%), and ion binding (11%) (Figure 2B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "MF", "analysis", ",", "differentially", "expressed", "proteins", "were", "mainly", "enriched", "in", "organic", "cyclic", "compound", "binding", "(", "20", "%", ")", ",", "oxygen", "binding", "(", "19", "%", ")", ",", "protein", "binding", "(", "19", "%", ")", ",", "and", "ion", "binding", "(", "11", "%", ")", "(", "Figure", "2B", ")", "." ] } ]
PMC9429973	This points to that a) a portion of the T cells present in an AML are leukemia-reactive but have been immunosuppressed - a suppression that can be reversed by the addition of a TCE, b) that this anti-AML T cell reactivation may play an important part of the mechanism of action of AML-targeted TCEs and c) that by understanding this reactivation mechanism, we will be able to design improved AML immunotherapies in the future.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "points", "to", "that", "a", ")", "a", "portion", "of", "the", "T", "cells", "present", "in", "an", "AML", "are", "leukemia-reactive", "but", "have", "been", "immunosuppressed", "-", "a", "suppression", "that", "can", "be", "reversed", "by", "the", "addition", "of", "a", "TCE", ",", "b", ")", "that", "this", "anti-AML", "T", "cell", "reactivation", "may", "play", "an", "important", "part", "of", "the", "mechanism", "of", "action", "of", "AML-targeted", "TCEs", "and", "c", ")", "that", "by", "understanding", "this", "reactivation", "mechanism", ",", "we", "will", "be", "able", "to", "design", "improved", "AML", "immunotherapies", "in", "the", "future", "." ] } ]
PMC8345486	The use of adenosine derivatives modified with boron clusters to overcome drug resistance may be important in the context of cisplatin-resistant cells, which are sensitive to these compounds as parental cell lines.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "use", "of", "adenosine", "derivatives", "modified", "with", "boron", "clusters", "to", "overcome", "drug", "resistance", "may", "be", "important", "in", "the", "context", "of", "cisplatin-resistant", "cells", ",", "which", "are", "sensitive", "to", "these", "compounds", "as", "parental", "cell", "lines", "." ] } ]
PMC9910796	Finally, the infected cells were harvested together with their culture supernatants at different times post-infection, sonicated and titrated by plaque assay in the presence of 1 mM IPTG.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Finally", ",", "the", "infected", "cells", "were", "harvested", "together", "with", "their", "culture", "supernatants", "at", "different", "times", "post-infection", ",", "sonicated", "and", "titrated", "by", "plaque", "assay", "in", "the", "presence", "of", "1", "mM", "IPTG", "." ] } ]
PMC11401358	Fig. 1 Schematic diagram of SF with an antioxidant function and its mechanism. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Fig.", "1", "Schematic", "diagram", "of", "SF", "with", "an", "antioxidant", "function", "and", "its", "mechanism", ".", "(" ] } ]
PMC11803918	Fluorescence imaging and biodistribution of free Ce6, Ce6-loaded liposomes, and hybrid γδ-T exosomes in A375 tumor-bearing nude mice in vivo at different time points after injection. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Fluorescence", "imaging", "and", "biodistribution", "of", "free", "Ce6", ",", "Ce6-loaded", "liposomes", ",", "and", "hybrid", "γδ-T", "exosomes", "in", "A375", "tumor-bearing", "nude", "mice", "in", "vivo", "at", "different", "time", "points", "after", "injection", ".", "(" ] } ]
PMC9910796	The sheep anti-TGN46 (AHP500G) was from Bio-Rad and the rabbit anti-pan-AKT antibody (ab880) from Abcam.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "sheep", "anti-TGN46", "(", "AHP500", "G", ")", "was", "from", "Bio-Rad", "and", "the", "rabbit", "anti-pan-AKT", "antibody", "(", "ab880", ")", "from", "Abcam", "." ] } ]
PMC9429973	SK and lc-WGS (0.2x) on plasma cf-DNA were assessed in 27/30 pts.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "SK", "and", "lc-WGS", "(", "0.2x", ")", "on", "plasma", "cf-DNA", "were", "assessed", "in", "27/30", "pts", "." ] } ]
PMC9812014	These alkaloids (tulongicin-A and dihydrospongotine-C) had an IC50 concentration of 3.9 μM and 2.7 μM against the YU2-HIV isolate respectively, while their IC50 concentrations against the HxB2-HIV isolate was 3.5 μM and 4.5 μM respectively .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "alkaloids", "(", "tulongicin-A", "and", "dihydrospongotine-C", ")", "had", "an", "IC50", "concentration", "of", "3.9", "μM", "and", "2.7", "μM", "against", "the", "YU2-HIV", "isolate", "respectively", ",", "while", "their", "IC50", "concentrations", "against", "the", "HxB2-HIV", "isolate", "was", "3.5", "μM", "and", "4.5", "μM", "respectively", "." ] } ]
PMC10588957	Given its key role in controlling energy homeostasis, AMPK has attracted widespread attention as a potential therapeutic target for metabolic diseases (22).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Given", "its", "key", "role", "in", "controlling", "energy", "homeostasis", ",", "AMPK", "has", "attracted", "widespread", "attention", "as", "a", "potential", "therapeutic", "target", "for", "metabolic", "diseases", "(", "22", ")", "." ] } ]
PMC11591030	AOP did not significantly affect the expression of other genes of NF-κB signaling pathway-related factors in the PBLs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "AOP", "did", "not", "significantly", "affect", "the", "expression", "of", "other", "genes", "of", "NF-κB", "signaling", "pathway-related", "factors", "in", "the", "PBLs", "." ] } ]
PMC11657744	Western blot analysis of Aurora A kinase level in NIH3T3 cells depleted of Cep89 or Fbf1 during ciliary disassembly.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Western", "blot", "analysis", "of", "Aurora", "A", "kinase", "level", "in", "NIH3T3", "cells", "depleted", "of", "Cep89", "or", "Fbf1", "during", "ciliary", "disassembly", "." ] } ]
PMC9429973	Summary/Conclusion: An integrated approach to the genetic diagnosis of MCL using standard cytogenetic and FISH studies makes it possible to identify a high-risk group: “double-hit” and with complex changes in the karyotype.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Summary/Conclusion", ":", "An", "integrated", "approach", "to", "the", "genetic", "diagnosis", "of", "MCL", "using", "standard", "cytogenetic", "and", "FISH", "studies", "makes", "it", "possible", "to", "identify", "a", "high-risk", "group", ":", "“", "double-hit", "”", "and", "with", "complex", "changes", "in", "the", "karyotype", "." ] } ]
PMC11216402	GTEx RNA-seq TPM values for 54 healthy human tissues were retrieved as described above.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "GTEx", "RNA-seq", "TPM", "values", "for", "54", "healthy", "human", "tissues", "were", "retrieved", "as", "described", "above", "." ] } ]
PMC10093184	ERBB2 and MALAT1 mRNA levels were highest in COS3600 and COS4074 cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O" ], "tokens": [ "ERBB2", "and", "MALAT1", "mRNA", "levels", "were", "highest", "in", "COS3600", "and", "COS4074", "cells", "." ] } ]
PMC3035438	We eluted the sample after purification in a buffer volume that allowed an over 10-fold enrichment of chimeric IgG (final concentration 5.61 µg/ml).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "eluted", "the", "sample", "after", "purification", "in", "a", "buffer", "volume", "that", "allowed", "an", "over", "10-fold", "enrichment", "of", "chimeric", "IgG", "(", "final", "concentration", "5.61", "µg/ml", ")", "." ] } ]
PMC11773391	No obvious difference was detected between the 1 μM vMF group and the control group.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "No", "obvious", "difference", "was", "detected", "between", "the", "1", "μM", "vMF", "group", "and", "the", "control", "group", "." ] } ]
PMC10362265	Panel shows the small region with different conformations in the complexes analyzed in this study.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Panel", "shows", "the", "small", "region", "with", "different", "conformations", "in", "the", "complexes", "analyzed", "in", "this", "study", "." ] } ]
PMC11045125	EBV-negative Akata BL cells serve as a positive control for Myc expression (and other cellular proteins such as CD10 expressed in BL tumors) and a negative control for EBV protein expression, while an AG876 wild-type EBV-infected LCL serves as a positive control for viral proteins expressed in type III latency.	[ { "tags": [ "O", "B-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "EBV-negative", "Akata", "BL", "cells", "serve", "as", "a", "positive", "control", "for", "Myc", "expression", "(", "and", "other", "cellular", "proteins", "such", "as", "CD10", "expressed", "in", "BL", "tumors", ")", "and", "a", "negative", "control", "for", "EBV", "protein", "expression", ",", "while", "an", "AG876", "wild-type", "EBV-infected", "LCL", "serves", "as", "a", "positive", "control", "for", "viral", "proteins", "expressed", "in", "type", "III", "latency", "." ] } ]
PMC8170755	Moreover, Nm23-H1 upregulation has been related to MMP-9 suppression in yet another report (30).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Moreover", ",", "Nm23-H1", "upregulation", "has", "been", "related", "to", "MMP-9", "suppression", "in", "yet", "another", "report", "(", "30", ")", "." ] } ]
PMC9429973	Binding of HexaBody-CD38 to CD38 cell lines SU-DHL-4, NCI-H929, and Wien-133 that were pre-treated with daratumumab or isatuximab was allowed for 15 min, 1 h, 4 h or 24 h, while daratumumab or isatuximab remained present at saturating concentrations.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Binding", "of", "HexaBody-CD38", "to", "CD38", "cell", "lines", "SU-DHL-4", ",", "NCI-H929", ",", "and", "Wien-133", "that", "were", "pre-treated", "with", "daratumumab", "or", "isatuximab", "was", "allowed", "for", "15", "min", ",", "1", "h", ",", "4", "h", "or", "24", "h", ",", "while", "daratumumab", "or", "isatuximab", "remained", "present", "at", "saturating", "concentrations", "." ] } ]
PMC11615101	Rheumatoid arthritis (RA) is the most common chronic, systemic inflammatory autoimmune disease of joints, affecting around 1% of the population worldwide.1 It stood at 42 ranks among 291 contributors to the disability index and contributed to modest global disability.2 The risk factors affect the immune cells to produce self-antigens, which enables the production of autoantibodies and anti-citrullinated protein antibodies (ACPA), causing inflammation and joint destruction.1 Despite many efforts, the etiology of RA is still not understood well.1 Manifestation of RA is marked by inflammation of the synovial membrane and articular tissue caused by the participation of immune cells (T cells, B cells, dendritic cells, macrophages, neutrophils) and non-immune cells (fibroblasts and chondrocytes).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Rheumatoid", "arthritis", "(", "RA", ")", "is", "the", "most", "common", "chronic", ",", "systemic", "inflammatory", "autoimmune", "disease", "of", "joints", ",", "affecting", "around", "1", "%", "of", "the", "population", "worldwide.1", "It", "stood", "at", "42", "ranks", "among", "291", "contributors", "to", "the", "disability", "index", "and", "contributed", "to", "modest", "global", "disability.2", "The", "risk", "factors", "affect", "the", "immune", "cells", "to", "produce", "self-antigens", ",", "which", "enables", "the", "production", "of", "autoantibodies", "and", "anti-citrullinated", "protein", "antibodies", "(", "ACPA", ")", ",", "causing", "inflammation", "and", "joint", "destruction.1", "Despite", "many", "efforts", ",", "the", "etiology", "of", "RA", "is", "still", "not", "understood", "well.1", "Manifestation", "of", "RA", "is", "marked", "by", "inflammation", "of", "the", "synovial", "membrane", "and", "articular", "tissue", "caused", "by", "the", "participation", "of", "immune", "cells", "(", "T", "cells", ",", "B", "cells", ",", "dendritic", "cells", ",", "macrophages", ",", "neutrophils", ")", "and", "non-immune", "cells", "(", "fibroblasts", "and", "chondrocytes", ")", "." ] } ]
PMC7090062	To investigate a correlation between miR-30a and drug sensitivity, RT-qPCR assays were performed to determine the levels of miR-30a in the human GIST lines, GIST-882 and GIST-T1 cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O" ], "tokens": [ "To", "investigate", "a", "correlation", "between", "miR-30a", "and", "drug", "sensitivity", ",", "RT-qPCR", "assays", "were", "performed", "to", "determine", "the", "levels", "of", "miR-30a", "in", "the", "human", "GIST", "lines", ",", "GIST-882", "and", "GIST-T1", "cells", "." ] } ]
PMC11495567	When a series of PCAIs were tested for their effects on the viability of NCI-H23 cells, significant decreases in cell densities and viability were observed following 48 h of treatment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "When", "a", "series", "of", "PCAIs", "were", "tested", "for", "their", "effects", "on", "the", "viability", "of", "NCI-H23", "cells", ",", "significant", "decreases", "in", "cell", "densities", "and", "viability", "were", "observed", "following", "48", "h", "of", "treatment", "." ] } ]
PMC9429973	Aims: To examine treatment patterns, clinical outcomes, and HCRU in patients with LR-MDS who reinitiated treatment with ESAs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Aims", ":", "To", "examine", "treatment", "patterns", ",", "clinical", "outcomes", ",", "and", "HCRU", "in", "patients", "with", "LR-MDS", "who", "reinitiated", "treatment", "with", "ESAs", "." ] } ]
PMC11754094	The CRISPR-Cas system, derived from a prokaryotic immune response, uses single-guide RNAs (sgRNAs) to recognize target DNA sequences and then introduces DNA double-strand breaks (DSBs) at the target sites.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "CRISPR-Cas", "system", ",", "derived", "from", "a", "prokaryotic", "immune", "response", ",", "uses", "single-guide", "RNAs", "(", "sgRNAs", ")", "to", "recognize", "target", "DNA", "sequences", "and", "then", "introduces", "DNA", "double-strand", "breaks", "(", "DSBs", ")", "at", "the", "target", "sites", "." ] } ]
PMC11694066	To form spheroids, 500 JN1 cells in 200 μL of media were plated into each well of 96-well ultralow attachment plates (#7007, Corning).	[ { "tags": [ "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "form", "spheroids", ",", "500", "JN1", "cells", "in", "200", "μL", "of", "media", "were", "plated", "into", "each", "well", "of", "96-well", "ultralow", "attachment", "plates", "(", "#", "7007", ",", "Corning", ")", "." ] } ]
PMC11055510	Due to the specificity of its origin, it has also been used as a research model to mimic precancerous ovarian lesions in vitro.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Due", "to", "the", "specificity", "of", "its", "origin", ",", "it", "has", "also", "been", "used", "as", "a", "research", "model", "to", "mimic", "precancerous", "ovarian", "lesions", "in", "vitro", "." ] } ]
PMC10823017	Monotherapy with BYL did not produce a significant reduction in the total ERK1/2 in 786-0 cells compared to the control group.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Monotherapy", "with", "BYL", "did", "not", "produce", "a", "significant", "reduction", "in", "the", "total", "ERK1/2", "in", "786", "-", "0", "cells", "compared", "to", "the", "control", "group", "." ] } ]
PMC11756514	Langerin-expressing HEK293 cells, like MGL-expressing HEK293 cells, did not bind any of the S. pneumoniae strains.	[ { "tags": [ "O", "B-CellLine", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Langerin-expressing", "HEK293", "cells", ",", "like", "MGL-expressing", "HEK293", "cells", ",", "did", "not", "bind", "any", "of", "the", "S.", "pneumoniae", "strains", "." ] } ]
PMC11075223	The Shengma decoction in Benshi Prescription applied to the treatment of chest and breast pain, while in Shengji Zonglu cured abdominal fullness.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "Shengma", "decoction", "in", "Benshi", "Prescription", "applied", "to", "the", "treatment", "of", "chest", "and", "breast", "pain", ",", "while", "in", "Shengji", "Zonglu", "cured", "abdominal", "fullness", "." ] } ]
PMC6901583	These issues necessitate a thorough comprehension of the mechanisms of GIST pathology.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "issues", "necessitate", "a", "thorough", "comprehension", "of", "the", "mechanisms", "of", "GIST", "pathology", "." ] } ]
PMC9429973	Aims: We aimed to dissect the cellular and molecular mechanisms underpinning CMML maintenance and progression in RAS mutant CMML.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Aims", ":", "We", "aimed", "to", "dissect", "the", "cellular", "and", "molecular", "mechanisms", "underpinning", "CMML", "maintenance", "and", "progression", "in", "RAS", "mutant", "CMML", "." ] } ]
PMC11441402	Drugs were added to cells and incubated for 48 h. The number of cells determined at the time of treatment (Tz) for each method was used to determine cell growth inhibition and cell death.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Drugs", "were", "added", "to", "cells", "and", "incubated", "for", "48", "h.", "The", "number", "of", "cells", "determined", "at", "the", "time", "of", "treatment", "(", "Tz", ")", "for", "each", "method", "was", "used", "to", "determine", "cell", "growth", "inhibition", "and", "cell", "death", "." ] } ]
PMC11546117	Previously, we developed a pig and minipig in vitro model of the mammary epithelial barrier , based on the assumption that the pig/minipig was selected by the ConcePTION consortium as an animal model for in vivo lactation studies .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Previously", ",", "we", "developed", "a", "pig", "and", "minipig", "in", "vitro", "model", "of", "the", "mammary", "epithelial", "barrier", ",", "based", "on", "the", "assumption", "that", "the", "pig/minipig", "was", "selected", "by", "the", "ConcePTION", "consortium", "as", "an", "animal", "model", "for", "in", "vivo", "lactation", "studies", "." ] } ]
PMC11597291	The obtained solutions were assayed for PCT by UV–Vis spectroscopy at 227 nm, as described above.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "obtained", "solutions", "were", "assayed", "for", "PCT", "by", "UV", "–", "Vis", "spectroscopy", "at", "227", "nm", ",", "as", "described", "above", "." ] } ]
PMC9895440	was used according to the manufacturer’s instruction and measured on a Fortessa (BD).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "was", "used", "according", "to", "the", "manufacturer", "’s", "instruction", "and", "measured", "on", "a", "Fortessa", "(", "BD", ")", "." ] } ]
PMC11544122	β-arrestins can interact with the transmembrane bundle after interacting with phospho-sites on the CT of GPCRs as well as exclusively with CT phosphosites; however, how SNX9 binds to GPCRs remains to be determined.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "β-arrestins", "can", "interact", "with", "the", "transmembrane", "bundle", "after", "interacting", "with", "phospho-sites", "on", "the", "CT", "of", "GPCRs", "as", "well", "as", "exclusively", "with", "CT", "phosphosites", ";", "however", ",", "how", "SNX9", "binds", "to", "GPCRs", "remains", "to", "be", "determined", "." ] } ]
PMC7215832	In addition, this study underlines the relevance of DNA methylation as a potential biomarker for RX-3117′s anti-tumor activity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "addition", ",", "this", "study", "underlines", "the", "relevance", "of", "DNA", "methylation", "as", "a", "potential", "biomarker", "for", "RX-3117′s", "anti-tumor", "activity", "." ] } ]
PMC10723784	Selectivity index of CBD‐induced toxicity as compared to ARPE19 and PNT2 cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O" ], "tokens": [ "Selectivity", "index", "of", "CBD‐induced", "toxicity", "as", "compared", "to", "ARPE19", "and", "PNT2", "cells", "." ] } ]
PMC10529414	When more than two groups were compared, the Kruskal–Wallis test followed by Dunn’s multiple comparison test was used.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "When", "more", "than", "two", "groups", "were", "compared", ",", "the", "Kruskal", "–", "Wallis", "test", "followed", "by", "Dunn", "’s", "multiple", "comparison", "test", "was", "used", "." ] } ]
PMC5854676	The mathematical model and its validity is described in the mathematical model section.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "mathematical", "model", "and", "its", "validity", "is", "described", "in", "the", "mathematical", "model", "section", "." ] } ]
PMC9429973	Summary/Conclusion: Our results indicate that the density of cells of adaptive immunity in the bone marrow specimens may significantly contribute to outcome (overall survival and time to transformation to AML) of high-risk MDS patients and alter response to treatment with 5-AZA.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Summary/Conclusion", ":", "Our", "results", "indicate", "that", "the", "density", "of", "cells", "of", "adaptive", "immunity", "in", "the", "bone", "marrow", "specimens", "may", "significantly", "contribute", "to", "outcome", "(", "overall", "survival", "and", "time", "to", "transformation", "to", "AML", ")", "of", "high-risk", "MDS", "patients", "and", "alter", "response", "to", "treatment", "with", "5-AZA", "." ] } ]
PMC9341513	We previously showed that, in malignant B cells, genome rearrangements involving CCND1 lead to local changes in histone modifications (Mikulasova et al. 2022).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "previously", "showed", "that", ",", "in", "malignant", "B", "cells", ",", "genome", "rearrangements", "involving", "CCND1", "lead", "to", "local", "changes", "in", "histone", "modifications", "(", "Mikulasova", "et", "al.", "2022", ")", "." ] } ]
PMC8973725	Q-MSP results showing ZNF677 methylation levels in ccRCC tissues and normal tissues.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Q-MSP", "results", "showing", "ZNF677", "methylation", "levels", "in", "ccRCC", "tissues", "and", "normal", "tissues", "." ] } ]
PMC4355729	Cells were maintained in serum-free 1:1 DMEM/F12 (Gibco) supplemented with 20 ng/mL EGF (Invitrogen), 20 ng/mL bFGF (Invitrogen), 2% B27 (Invitrogen), 1% N2 (Invitrogen), and 100 mg/mL streptomycin (Gibco).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cells", "were", "maintained", "in", "serum-free", "1:1", "DMEM/F12", "(", "Gibco", ")", "supplemented", "with", "20", "ng/mL", "EGF", "(", "Invitrogen", ")", ",", "20", "ng/mL", "bFGF", "(", "Invitrogen", ")", ",", "2", "%", "B27", "(", "Invitrogen", ")", ",", "1", "%", "N2", "(", "Invitrogen", ")", ",", "and", "100", "mg/mL", "streptomycin", "(", "Gibco", ")", "." ] } ]
PMC11694625	Systemic toxicological evaluation of antitumor drug activity is very important because most chemotherapeutic cancer agents are non-specific in action; besides attacking tumors, they rapidly demolish normally dividing cells, and can cause extensive collateral side effects.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Systemic", "toxicological", "evaluation", "of", "antitumor", "drug", "activity", "is", "very", "important", "because", "most", "chemotherapeutic", "cancer", "agents", "are", "non-specific", "in", "action", ";", "besides", "attacking", "tumors", ",", "they", "rapidly", "demolish", "normally", "dividing", "cells", ",", "and", "can", "cause", "extensive", "collateral", "side", "effects", "." ] } ]
PMC4277423	It contains the CR1, CR2 and CR3 sequences.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "contains", "the", "CR1", ",", "CR2", "and", "CR3", "sequences", "." ] } ]
PMC5925824	Only N63Q and not H69A abrogated the binding of LY3300054 to hu-PD-L1-Fc Additional file 1: Figure S3.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Only", "N63Q", "and", "not", "H69A", "abrogated", "the", "binding", "of", "LY3300054", "to", "hu-PD-L1-Fc", "Additional", "file", "1", ":", "Figure", "S3", "." ] } ]
PMC11535726	These taxa produced a dendryphiopsis- or sporidesmium-like asexual morph and detailed descriptions and micromorphological illustrations are provided.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "taxa", "produced", "a", "dendryphiopsis-", "or", "sporidesmium-like", "asexual", "morph", "and", "detailed", "descriptions", "and", "micromorphological", "illustrations", "are", "provided", "." ] } ]
PMC9812014	HHT was efficient in its anti-NDV activity, and it acted against NDV by lowering the viral load in NDV-infected cells, embryos, and animals.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "HHT", "was", "efficient", "in", "its", "anti-NDV", "activity", ",", "and", "it", "acted", "against", "NDV", "by", "lowering", "the", "viral", "load", "in", "NDV-infected", "cells", ",", "embryos", ",", "and", "animals", "." ] } ]
PMC9429973	In MPN, bone marrow-derived mesenchymal stromal cells (BM-MSC) are identified as a major cellular source of fibrosis, but exact molecular mechanism involved have not been identified so far.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "MPN", ",", "bone", "marrow-derived", "mesenchymal", "stromal", "cells", "(", "BM-MSC", ")", "are", "identified", "as", "a", "major", "cellular", "source", "of", "fibrosis", ",", "but", "exact", "molecular", "mechanism", "involved", "have", "not", "been", "identified", "so", "far", "." ] } ]
PMC11585254	Cells were then incubated with the anti-FLAG M2 alkaline phosphatase-conjugated antibody at a 1:1000 dilution in TBS/bovine serum albumin for 1 hour at room temperature while gently rocking.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cells", "were", "then", "incubated", "with", "the", "anti-FLAG", "M2", "alkaline", "phosphatase-conjugated", "antibody", "at", "a", "1:1000", "dilution", "in", "TBS/bovine", "serum", "albumin", "for", "1", "hour", "at", "room", "temperature", "while", "gently", "rocking", "." ] } ]
PMC9429973	According to the ROC curve between the concentration of Reg3α and disease outcome in the two groups about one month before transplantation, the optimal critical value was calculated as 1200.57 pg/mL, and the AUC was 0.938 (95% confidence interval was 0.792-1.000, P<0.05).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "According", "to", "the", "ROC", "curve", "between", "the", "concentration", "of", "Reg3α", "and", "disease", "outcome", "in", "the", "two", "groups", "about", "one", "month", "before", "transplantation", ",", "the", "optimal", "critical", "value", "was", "calculated", "as", "1200.57", "pg/mL", ",", "and", "the", "AUC", "was", "0.938", "(", "95", "%", "confidence", "interval", "was", "0.792", "-", "1.000", ",", "P<0.05", ")", "." ] } ]
PMC9587298	At acidic pH, anthocyanins have a positive charge, thus ionizing preferentially in positive ion mode as M ions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "At", "acidic", "pH", ",", "anthocyanins", "have", "a", "positive", "charge", ",", "thus", "ionizing", "preferentially", "in", "positive", "ion", "mode", "as", "M", "ions", "." ] } ]
PMC11281366	The multiplicity of infection (MOI) was determined using the CEM-CCR5 cell line.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O" ], "tokens": [ "The", "multiplicity", "of", "infection", "(", "MOI", ")", "was", "determined", "using", "the", "CEM-CCR5", "cell", "line", "." ] } ]
PMC9250505	B 3D matrigel growth: Survival fraction (SF) was evaluated using the ApoTox-Glo triplex assay Kit in CAOV2 cells treated with NPB (N), PARP inhibitors (OlaparibO, Rucaparib = R, Talazoparib = T) alone or in combination with the indicated concentrations for 14 days in 3D Matrigel culture (n = 3).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "B", "3D", "matrigel", "growth", ":", "Survival", "fraction", "(", "SF", ")", "was", "evaluated", "using", "the", "ApoTox-Glo", "triplex", "assay", "Kit", "in", "CAOV2", "cells", "treated", "with", "NPB", "(", "N", ")", ",", "PARP", "inhibitors", "(", "OlaparibO", ",", "Rucaparib", "=", "R", ",", "Talazoparib", "=", "T", ")", "alone", "or", "in", "combination", "with", "the", "indicated", "concentrations", "for", "14", "days", "in", "3D", "Matrigel", "culture", "(", "n", "=", "3", ")", "." ] } ]
PMC9429973	Results: Twenty-six patients were screened, of which 17 (9 Japan, 7 Korea, and 1 Taiwan; 5 transfusion dependent non-severe AA, 6 severe AA (SAA) and 6 very SAA) were enrolled in the study.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Results", ":", "Twenty-six", "patients", "were", "screened", ",", "of", "which", "17", "(", "9", "Japan", ",", "7", "Korea", ",", "and", "1", "Taiwan", ";", "5", "transfusion", "dependent", "non-severe", "AA", ",", "6", "severe", "AA", "(", "SAA", ")", "and", "6", "very", "SAA", ")", "were", "enrolled", "in", "the", "study", "." ] } ]
PMC10914904	The transcription factor NF-κB has an impact on tumor development and progression through excessive innate immune activation and abnormal cell proliferation .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "transcription", "factor", "NF-κB", "has", "an", "impact", "on", "tumor", "development", "and", "progression", "through", "excessive", "innate", "immune", "activation", "and", "abnormal", "cell", "proliferation", "." ] } ]
PMC10547921	These side-chain-modified eribulin analogs are significantly more potent on U-251 and SF-295 cells than eribulin.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O" ], "tokens": [ "These", "side-chain-modified", "eribulin", "analogs", "are", "significantly", "more", "potent", "on", "U-251", "and", "SF-295", "cells", "than", "eribulin", "." ] } ]
PMC11474209	Water pollution has become a worldwide issue, and challenges regarding water quality are currently at the forefront of global action.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Water", "pollution", "has", "become", "a", "worldwide", "issue", ",", "and", "challenges", "regarding", "water", "quality", "are", "currently", "at", "the", "forefront", "of", "global", "action", "." ] } ]
PMC11672142	The viability of Jurkat cells was examined in a 72 h treatment with DefNEtTrp, Def, NEtTrp, and Trp, a 1:1 combination of Def and NEtTrp, and a 1:1 combination of Def and Trp.	[ { "tags": [ "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "viability", "of", "Jurkat", "cells", "was", "examined", "in", "a", "72", "h", "treatment", "with", "DefNEtTrp", ",", "Def", ",", "NEtTrp", ",", "and", "Trp", ",", "a", "1:1", "combination", "of", "Def", "and", "NEtTrp", ",", "and", "a", "1:1", "combination", "of", "Def", "and", "Trp", "." ] } ]
PMC11381192	Specifically, calibration curves were constructed based on 1000 bootstrap resamples to estimate the degree of deviation between observed and predicted survival probabilities.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Specifically", ",", "calibration", "curves", "were", "constructed", "based", "on", "1000", "bootstrap", "resamples", "to", "estimate", "the", "degree", "of", "deviation", "between", "observed", "and", "predicted", "survival", "probabilities", "." ] } ]
PMC11549062	After 24 h, a straight line was carefully drawn across the plate using a 1000‐μL pipette tip.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "24", "h", ",", "a", "straight", "line", "was", "carefully", "drawn", "across", "the", "plate", "using", "a", "1000‐μL", "pipette", "tip", "." ] } ]
PMC11194678	All data are represented as mean ± SD.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "data", "are", "represented", "as", "mean", "±", "SD", "." ] } ]
PMC11342785	By comparison, the proposed mechanism for controlling TPPP activity in oligodendrocytes depends on its targeting to a recently discovered class of discrete and highly localized cell-type–specific structures called Golgi outposts (29, 43, 44, 45).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "By", "comparison", ",", "the", "proposed", "mechanism", "for", "controlling", "TPPP", "activity", "in", "oligodendrocytes", "depends", "on", "its", "targeting", "to", "a", "recently", "discovered", "class", "of", "discrete", "and", "highly", "localized", "cell-type", "–", "specific", "structures", "called", "Golgi", "outposts", "(", "29", ",", "43", ",", "44", ",", "45", ")", "." ] } ]
PMC7762347	Significance differences between solvent control and treated groups were evaluated by One-way analysis of variance (Dunnett’s Multiple Comparison Test). (*	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Significance", "differences", "between", "solvent", "control", "and", "treated", "groups", "were", "evaluated", "by", "One-way", "analysis", "of", "variance", "(", "Dunnett", "’s", "Multiple", "Comparison", "Test", ")", ".", "(", "*" ] } ]
PMC8751435	The results show cordycepin and adenosine are detected in CME, and the contents of them were 3749.29 ± 36.90 and 4022.26 ± 13.58 mg/kg, respectively, in CME (Figure 7c,d).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "results", "show", "cordycepin", "and", "adenosine", "are", "detected", "in", "CME", ",", "and", "the", "contents", "of", "them", "were", "3749.29", "±", "36.90", "and", "4022.26", "±", "13.58", "mg/kg", ",", "respectively", ",", "in", "CME", "(", "Figure", "7c", ",", "d", ")", "." ] } ]
PMC8303372	The toxicity of empty NPs was also assessed.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "toxicity", "of", "empty", "NPs", "was", "also", "assessed", "." ] } ]
PMC8382973	The amplified products in each reaction mixture were aggregated in equal molar ratios according to their concentration.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "amplified", "products", "in", "each", "reaction", "mixture", "were", "aggregated", "in", "equal", "molar", "ratios", "according", "to", "their", "concentration", "." ] } ]
PMC11656657	Strategies to tackle hostile immunosuppressive MDSC are desirable to optimize CAR.GD2 T-cell activity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Strategies", "to", "tackle", "hostile", "immunosuppressive", "MDSC", "are", "desirable", "to", "optimize", "CAR.GD2", "T-cell", "activity", "." ] } ]
PMC11599565	The cells that have moved to a neuroepithelial condition are in a transitory status of dormancy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "cells", "that", "have", "moved", "to", "a", "neuroepithelial", "condition", "are", "in", "a", "transitory", "status", "of", "dormancy", "." ] } ]
PMC11704135	Moreover, pyrimidine serves as a fundamental component in the chemical structure of numerous commercially available drugs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Moreover", ",", "pyrimidine", "serves", "as", "a", "fundamental", "component", "in", "the", "chemical", "structure", "of", "numerous", "commercially", "available", "drugs", "." ] } ]
PMC11697703	Experimental approach. (	[ { "tags": [ "O", "O", "O", "O" ], "tokens": [ "Experimental", "approach", ".", "(" ] } ]
PMC11401350	Vectors were titered for physical particles by measuring p24 antigen using an enzyme-linked immune-absorbant assay (ELISA) following manufacturer’s instructions (RetroTek-ZeptoMetrix, Buffalo, NY).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Vectors", "were", "titered", "for", "physical", "particles", "by", "measuring", "p24", "antigen", "using", "an", "enzyme-linked", "immune-absorbant", "assay", "(", "ELISA", ")", "following", "manufacturer", "’s", "instructions", "(", "RetroTek-ZeptoMetrix", ",", "Buffalo", ",", "NY", ")", "." ] } ]
PMC10969097	The diversity of this natural source is clearly yet to be investigated, particularly as a strategy for enhancing the effect of chemotherapy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "diversity", "of", "this", "natural", "source", "is", "clearly", "yet", "to", "be", "investigated", ",", "particularly", "as", "a", "strategy", "for", "enhancing", "the", "effect", "of", "chemotherapy", "." ] } ]
PMC11585587	The bar chart of the top 20 signal pathways in the KEGG enrichment analysis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "bar", "chart", "of", "the", "top", "20", "signal", "pathways", "in", "the", "KEGG", "enrichment", "analysis", "." ] } ]
PMC4659567	Electrospray ionization (ESI) mass spectra of the methanol solution were obtained of on a LCQ Fleet Ion Trap mass spectrometer (Thermo Scientific; Qual Browser software, version 2.0.7) in the positive ionization mode (ESI+).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Electrospray", "ionization", "(", "ESI", ")", "mass", "spectra", "of", "the", "methanol", "solution", "were", "obtained", "of", "on", "a", "LCQ", "Fleet", "Ion", "Trap", "mass", "spectrometer", "(", "Thermo", "Scientific", ";", "Qual", "Browser", "software", ",", "version", "2.0.7", ")", "in", "the", "positive", "ionization", "mode", "(", "ESI+", ")", "." ] } ]
PMC11395280	In our studies, CCRF-CEM migrated across the barrier formed by these cells in response to CCL19 and CCL21.	[ { "tags": [ "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "our", "studies", ",", "CCRF-CEM", "migrated", "across", "the", "barrier", "formed", "by", "these", "cells", "in", "response", "to", "CCL19", "and", "CCL21", "." ] } ]
PMC8481254	C Colony-formation assay of Bel-7402 and Bel-7404 cells treated with methanol or 40 μM CA.	[ { "tags": [ "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "C", "Colony-formation", "assay", "of", "Bel-7402", "and", "Bel-7404", "cells", "treated", "with", "methanol", "or", "40", "μM", "CA", "." ] } ]
PMC9429973	Around the year 2000 it became possible to add the monoclonal CD20 antibody rituximab, resulting in improved overall survival .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Around", "the", "year", "2000", "it", "became", "possible", "to", "add", "the", "monoclonal", "CD20", "antibody", "rituximab", ",", "resulting", "in", "improved", "overall", "survival", "." ] } ]
PMC11411131	Only Krab-Sec driven by the CMV promoter, not by the EF1α promoter, successfully decreased pTre-Luc activity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Only", "Krab-Sec", "driven", "by", "the", "CMV", "promoter", ",", "not", "by", "the", "EF1α", "promoter", ",", "successfully", "decreased", "pTre-Luc", "activity", "." ] } ]
PMC11750161	The mixed samples (2.4 mL) were gently added to the cell suspension flask.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "mixed", "samples", "(", "2.4", "mL", ")", "were", "gently", "added", "to", "the", "cell", "suspension", "flask", "." ] } ]
PMC9429973	Imatinib was the first line TKI used.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Imatinib", "was", "the", "first", "line", "TKI", "used", "." ] } ]
PMC9164404	The results showed that the BEL-7404 cells in a 3D cell sphere after treated with Abplatin showed strong red fluorescence(Fig.	[ { "tags": [ "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "results", "showed", "that", "the", "BEL-7404", "cells", "in", "a", "3D", "cell", "sphere", "after", "treated", "with", "Abplatin", "showed", "strong", "red", "fluorescence(Fig", "." ] } ]

PMC8922418

Thus, this crRNA library may serve as a preventive treatment against future pathogenic coronaviruses that evolved to escape immune surveillance (Abbott et al., 2020).

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PMC11765988

MicroRNAs may be linked to various forms of lymphoma and sarcoidosis.

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PMC9954564

Among the SNPs significantly associated with the dominant model (Table 2), rs6932888 and rs6932596 are in strong LD with each other (r ≥ 0.90).

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PMC11026382

This means that these DHFR mutations are more deleterious in the background of TYMS Q33S than in the native TYMS context.

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PMC9429973

Key words: hemophilia A, pharmacokinetics, children, one-chamber model, non-av-model H. Patel, S. Peltier, K. Clark, M. T. Reding Bio Products Laboratory Ltd. UK, Elstree, United Kingdom; University of Minnesota Medical Center, Minneapolis; Bio Products Laboratory USA, Inc., Durham, United States of America Background: Coagulation factor X, human is a plasma-derived factor X concentrate indicated to treat and prevent bleeding in individuals with hereditary factor X deficiency (HFXD).

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PMC9684669

CAMK2D’s apparent aggregation temperature (Tagg) was evaluated in the absence or presence of terfenadine in A2780-ADR cell lysates ( Figure 5F and Figure S6C ).

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PMC7823217

The potential precursor of cervical cancer is cervical intraepithelial neoplasia.

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PMC9429973

The median age was 60 years (range 19-89) and 96 (59%) were female.

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PMC10723784

Previous studies have also reported the induction of apoptosis by CBD in breast, prostate, glioma, and colon cancers, whereas CBG‐induced apoptosis was observed in prostate and colon cancers. , , ,

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PMC11679892

After removing the PBS, 500 μL Trizol was added to the wells to lift the cells.

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PMC10988555

Figure S17 demonstrates that complexes 2–4 interact with CT-DNA and by increasing its concentration an effect in the lowest-energy absorption band is observed, namely, a small hyperchromic effect for complex 2 and a hypochromic effect for 3 and 4, with no major shifts on the bands.

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PMC7153288

Values were represented as mean ± SD (n = 3).Fig.

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PMC11321678

Therefore, understanding the internal regulatory program and complex cell‐cell interaction of MB will greatly expand the range of therapeutic approaches.

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PMC11457557

In 2018, the FTO gene locus showed an association with DKD (SNP rs56094641) (P = 7.7 × 10 − 10) in GWAS of Japanese individuals with T2DM.

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PMC11391695

HCC cells were incubated in 48-well plates containing 100 µL of EdU working solution for a duration of 2 h. The cells were then immersed for 15 min in a 4% solution of paraformaldehyde before being encapsulated in a PBS solution supplemented with 3% bovine serum albumin (BSA).

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PMC7685376

In MF analysis, differentially expressed proteins were mainly enriched in organic cyclic compound binding (20%), oxygen binding (19%), protein binding (19%), and ion binding (11%) (Figure 2B).

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PMC9429973

This points to that a) a portion of the T cells present in an AML are leukemia-reactive but have been immunosuppressed - a suppression that can be reversed by the addition of a TCE, b) that this anti-AML T cell reactivation may play an important part of the mechanism of action of AML-targeted TCEs and c) that by understanding this reactivation mechanism, we will be able to design improved AML immunotherapies in the future.

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PMC8345486

The use of adenosine derivatives modified with boron clusters to overcome drug resistance may be important in the context of cisplatin-resistant cells, which are sensitive to these compounds as parental cell lines.

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PMC9910796

Finally, the infected cells were harvested together with their culture supernatants at different times post-infection, sonicated and titrated by plaque assay in the presence of 1 mM IPTG.

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PMC11401358

Fig. 1 Schematic diagram of SF with an antioxidant function and its mechanism. (

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PMC11803918

Fluorescence imaging and biodistribution of free Ce6, Ce6-loaded liposomes, and hybrid γδ-T exosomes in A375 tumor-bearing nude mice in vivo at different time points after injection. (

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PMC9910796

The sheep anti-TGN46 (AHP500G) was from Bio-Rad and the rabbit anti-pan-AKT antibody (ab880) from Abcam.

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PMC9429973

SK and lc-WGS (0.2x) on plasma cf-DNA were assessed in 27/30 pts.

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PMC9812014

These alkaloids (tulongicin-A and dihydrospongotine-C) had an IC50 concentration of 3.9 μM and 2.7 μM against the YU2-HIV isolate respectively, while their IC50 concentrations against the HxB2-HIV isolate was 3.5 μM and 4.5 μM respectively .

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PMC10588957

Given its key role in controlling energy homeostasis, AMPK has attracted widespread attention as a potential therapeutic target for metabolic diseases (22).

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PMC11591030

AOP did not significantly affect the expression of other genes of NF-κB signaling pathway-related factors in the PBLs.

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PMC11657744

Western blot analysis of Aurora A kinase level in NIH3T3 cells depleted of Cep89 or Fbf1 during ciliary disassembly.

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PMC9429973

Summary/Conclusion: An integrated approach to the genetic diagnosis of MCL using standard cytogenetic and FISH studies makes it possible to identify a high-risk group: “double-hit” and with complex changes in the karyotype.

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PMC11216402

GTEx RNA-seq TPM values for 54 healthy human tissues were retrieved as described above.

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PMC10093184

ERBB2 and MALAT1 mRNA levels were highest in COS3600 and COS4074 cells.

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PMC3035438

We eluted the sample after purification in a buffer volume that allowed an over 10-fold enrichment of chimeric IgG (final concentration 5.61 µg/ml).

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PMC11773391

No obvious difference was detected between the 1 μM vMF group and the control group.

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PMC10362265

Panel shows the small region with different conformations in the complexes analyzed in this study.

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PMC11045125

EBV-negative Akata BL cells serve as a positive control for Myc expression (and other cellular proteins such as CD10 expressed in BL tumors) and a negative control for EBV protein expression, while an AG876 wild-type EBV-infected LCL serves as a positive control for viral proteins expressed in type III latency.

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PMC8170755

Moreover, Nm23-H1 upregulation has been related to MMP-9 suppression in yet another report (30).

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PMC9429973

Binding of HexaBody-CD38 to CD38 cell lines SU-DHL-4, NCI-H929, and Wien-133 that were pre-treated with daratumumab or isatuximab was allowed for 15 min, 1 h, 4 h or 24 h, while daratumumab or isatuximab remained present at saturating concentrations.

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PMC11615101

Rheumatoid arthritis (RA) is the most common chronic, systemic inflammatory autoimmune disease of joints, affecting around 1% of the population worldwide.1 It stood at 42 ranks among 291 contributors to the disability index and contributed to modest global disability.2 The risk factors affect the immune cells to produce self-antigens, which enables the production of autoantibodies and anti-citrullinated protein antibodies (ACPA), causing inflammation and joint destruction.1 Despite many efforts, the etiology of RA is still not understood well.1 Manifestation of RA is marked by inflammation of the synovial membrane and articular tissue caused by the participation of immune cells (T cells, B cells, dendritic cells, macrophages, neutrophils) and non-immune cells (fibroblasts and chondrocytes).

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PMC7090062

To investigate a correlation between miR-30a and drug sensitivity, RT-qPCR assays were performed to determine the levels of miR-30a in the human GIST lines, GIST-882 and GIST-T1 cells.

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PMC11495567

When a series of PCAIs were tested for their effects on the viability of NCI-H23 cells, significant decreases in cell densities and viability were observed following 48 h of treatment.

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PMC9429973

Aims: To examine treatment patterns, clinical outcomes, and HCRU in patients with LR-MDS who reinitiated treatment with ESAs.

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PMC11754094

The CRISPR-Cas system, derived from a prokaryotic immune response, uses single-guide RNAs (sgRNAs) to recognize target DNA sequences and then introduces DNA double-strand breaks (DSBs) at the target sites.

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PMC11694066

To form spheroids, 500 JN1 cells in 200 μL of media were plated into each well of 96-well ultralow attachment plates (#7007, Corning).

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PMC11055510

Due to the specificity of its origin, it has also been used as a research model to mimic precancerous ovarian lesions in vitro.

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PMC10823017

Monotherapy with BYL did not produce a significant reduction in the total ERK1/2 in 786-0 cells compared to the control group.

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PMC11756514

Langerin-expressing HEK293 cells, like MGL-expressing HEK293 cells, did not bind any of the S. pneumoniae strains.

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PMC11075223

The Shengma decoction in Benshi Prescription applied to the treatment of chest and breast pain, while in Shengji Zonglu cured abdominal fullness.

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PMC6901583

These issues necessitate a thorough comprehension of the mechanisms of GIST pathology.

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PMC9429973

Aims: We aimed to dissect the cellular and molecular mechanisms underpinning CMML maintenance and progression in RAS mutant CMML.

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PMC11441402

Drugs were added to cells and incubated for 48 h. The number of cells determined at the time of treatment (Tz) for each method was used to determine cell growth inhibition and cell death.

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PMC11546117

Previously, we developed a pig and minipig in vitro model of the mammary epithelial barrier , based on the assumption that the pig/minipig was selected by the ConcePTION consortium as an animal model for in vivo lactation studies .

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PMC11597291

The obtained solutions were assayed for PCT by UV–Vis spectroscopy at 227 nm, as described above.

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PMC9895440

was used according to the manufacturer’s instruction and measured on a Fortessa (BD).

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PMC11544122

β-arrestins can interact with the transmembrane bundle after interacting with phospho-sites on the CT of GPCRs as well as exclusively with CT phosphosites; however, how SNX9 binds to GPCRs remains to be determined.

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PMC7215832

In addition, this study underlines the relevance of DNA methylation as a potential biomarker for RX-3117′s anti-tumor activity.

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PMC10723784

Selectivity index of CBD‐induced toxicity as compared to ARPE19 and PNT2 cells.

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PMC10529414

When more than two groups were compared, the Kruskal–Wallis test followed by Dunn’s multiple comparison test was used.

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PMC5854676

The mathematical model and its validity is described in the mathematical model section.

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PMC9429973

Summary/Conclusion: Our results indicate that the density of cells of adaptive immunity in the bone marrow specimens may significantly contribute to outcome (overall survival and time to transformation to AML) of high-risk MDS patients and alter response to treatment with 5-AZA.

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PMC9341513

We previously showed that, in malignant B cells, genome rearrangements involving CCND1 lead to local changes in histone modifications (Mikulasova et al. 2022).

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PMC8973725

Q-MSP results showing ZNF677 methylation levels in ccRCC tissues and normal tissues.

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PMC4355729

Cells were maintained in serum-free 1:1 DMEM/F12 (Gibco) supplemented with 20 ng/mL EGF (Invitrogen), 20 ng/mL bFGF (Invitrogen), 2% B27 (Invitrogen), 1% N2 (Invitrogen), and 100 mg/mL streptomycin (Gibco).

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PMC11694625

Systemic toxicological evaluation of antitumor drug activity is very important because most chemotherapeutic cancer agents are non-specific in action; besides attacking tumors, they rapidly demolish normally dividing cells, and can cause extensive collateral side effects.

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PMC4277423

It contains the CR1, CR2 and CR3 sequences.

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PMC5925824

Only N63Q and not H69A abrogated the binding of LY3300054 to hu-PD-L1-Fc Additional file 1: Figure S3.

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PMC11535726

These taxa produced a dendryphiopsis- or sporidesmium-like asexual morph and detailed descriptions and micromorphological illustrations are provided.

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PMC9812014

HHT was efficient in its anti-NDV activity, and it acted against NDV by lowering the viral load in NDV-infected cells, embryos, and animals.

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PMC9429973

In MPN, bone marrow-derived mesenchymal stromal cells (BM-MSC) are identified as a major cellular source of fibrosis, but exact molecular mechanism involved have not been identified so far.

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PMC11585254

Cells were then incubated with the anti-FLAG M2 alkaline phosphatase-conjugated antibody at a 1:1000 dilution in TBS/bovine serum albumin for 1 hour at room temperature while gently rocking.

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PMC9429973

According to the ROC curve between the concentration of Reg3α and disease outcome in the two groups about one month before transplantation, the optimal critical value was calculated as 1200.57 pg/mL, and the AUC was 0.938 (95% confidence interval was 0.792-1.000, P<0.05).

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PMC9587298

At acidic pH, anthocyanins have a positive charge, thus ionizing preferentially in positive ion mode as M ions.

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PMC11281366

The multiplicity of infection (MOI) was determined using the CEM-CCR5 cell line.

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PMC9250505

B 3D matrigel growth: Survival fraction (SF) was evaluated using the ApoTox-Glo triplex assay Kit in CAOV2 cells treated with NPB (N), PARP inhibitors (OlaparibO, Rucaparib = R, Talazoparib = T) alone or in combination with the indicated concentrations for 14 days in 3D Matrigel culture (n = 3).

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PMC9429973

Results: Twenty-six patients were screened, of which 17 (9 Japan, 7 Korea, and 1 Taiwan; 5 transfusion dependent non-severe AA, 6 severe AA (SAA) and 6 very SAA) were enrolled in the study.

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PMC10914904

The transcription factor NF-κB has an impact on tumor development and progression through excessive innate immune activation and abnormal cell proliferation .

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PMC10547921

These side-chain-modified eribulin analogs are significantly more potent on U-251 and SF-295 cells than eribulin.

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PMC11474209

Water pollution has become a worldwide issue, and challenges regarding water quality are currently at the forefront of global action.

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PMC11672142

The viability of Jurkat cells was examined in a 72 h treatment with DefNEtTrp, Def, NEtTrp, and Trp, a 1:1 combination of Def and NEtTrp, and a 1:1 combination of Def and Trp.

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PMC11381192

Specifically, calibration curves were constructed based on 1000 bootstrap resamples to estimate the degree of deviation between observed and predicted survival probabilities.

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PMC11549062

After 24 h, a straight line was carefully drawn across the plate using a 1000‐μL pipette tip.

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PMC11194678

All data are represented as mean ± SD.

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PMC11342785

By comparison, the proposed mechanism for controlling TPPP activity in oligodendrocytes depends on its targeting to a recently discovered class of discrete and highly localized cell-type–specific structures called Golgi outposts (29, 43, 44, 45).

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PMC7762347

Significance differences between solvent control and treated groups were evaluated by One-way analysis of variance (Dunnett’s Multiple Comparison Test). (*

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PMC8751435

The results show cordycepin and adenosine are detected in CME, and the contents of them were 3749.29 ± 36.90 and 4022.26 ± 13.58 mg/kg, respectively, in CME (Figure 7c,d).

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PMC8303372

The toxicity of empty NPs was also assessed.

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PMC8382973

The amplified products in each reaction mixture were aggregated in equal molar ratios according to their concentration.

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PMC11656657

Strategies to tackle hostile immunosuppressive MDSC are desirable to optimize CAR.GD2 T-cell activity.

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PMC11599565

The cells that have moved to a neuroepithelial condition are in a transitory status of dormancy.

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PMC11704135

Moreover, pyrimidine serves as a fundamental component in the chemical structure of numerous commercially available drugs.

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PMC11697703

Experimental approach. (

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PMC11401350

Vectors were titered for physical particles by measuring p24 antigen using an enzyme-linked immune-absorbant assay (ELISA) following manufacturer’s instructions (RetroTek-ZeptoMetrix, Buffalo, NY).

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PMC10969097

The diversity of this natural source is clearly yet to be investigated, particularly as a strategy for enhancing the effect of chemotherapy.

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PMC11585587

The bar chart of the top 20 signal pathways in the KEGG enrichment analysis.

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PMC4659567

Electrospray ionization (ESI) mass spectra of the methanol solution were obtained of on a LCQ Fleet Ion Trap mass spectrometer (Thermo Scientific; Qual Browser software, version 2.0.7) in the positive ionization mode (ESI+).

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PMC11395280

In our studies, CCRF-CEM migrated across the barrier formed by these cells in response to CCL19 and CCL21.

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PMC8481254

C Colony-formation assay of Bel-7402 and Bel-7404 cells treated with methanol or 40 μM CA.

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PMC9429973

Around the year 2000 it became possible to add the monoclonal CD20 antibody rituximab, resulting in improved overall survival .

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PMC11411131

Only Krab-Sec driven by the CMV promoter, not by the EF1α promoter, successfully decreased pTre-Luc activity.

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PMC11750161

The mixed samples (2.4 mL) were gently added to the cell suspension flask.

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PMC9429973

Imatinib was the first line TKI used.

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PMC9164404

The results showed that the BEL-7404 cells in a 3D cell sphere after treated with Abplatin showed strong red fluorescence(Fig.

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