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active\tform.\tPepsin\tis\tactive\tonly\tin\nthe\tacidic\tenvironment\tof\tthe\tstomach\tand\tacts\tto\tbegin\tthe\tprocess\tof\tprotein\tdigestion.\nAn\tacid-stable\tlipase\tis\tsecreted\tinto\tthe\tstomach\tby\tchief\tcells.\tAlthough\tthis\tlipase\tis\nconsiderably\tless\tactive\tthan\tpancreatic\tlipase,\tit\tcontributes\tto\tthe\toverall\tprocessing\tof\tdietary
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triglycerides.\tGastric\tlipase\tis\tmore\tspecific\tfor\ttriglycerides\tcomposed\tof\n\tmedium-\tand\tshort-chain\nfatty\tacids,\tbut\tthe\tusual\tdiet\tcontains\tfew\tof\tthese\tfats.\tLipases\tsecreted\tin\tthe\tupper\tportions\tof\nthe\tGIT\tmay\thave\ta\trelatively\timportant\trole\tin\tthe\tliquid\tdiet\tof\tinfants;\thowever,\twhen\tpancreatic
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insufficiency\toccurs,\tit\tbecomes\tapparent\tthat\tlingual\tand\tgastric\tlipases\tare\tnot\tsufficient\tto\nadequately\tdigest\tfat\tfrom\tfood\tand\tprevent\tlipid\tmalabsorption.\nWhen\tfood\n\tis\tconsumed,\tsignificant\tnumbers\tof\tmicroorganisms\tare\talso\tconsumed.\tThe\tstomach
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0.008057809434831142, 0.023039503023028374, -0.0473882332444191, 0.07027779519557953, 0.09793949127197266, -0.0750773698091507, -0.034123774617910385, 0.11610856652259827, -0.017157070338726044, -0.09430287033319473, -0.03308764472603798, 0.11387129873037338, 0.0057578301057219505, -0.02336842007935047, -0.0494069904088974, 0.01782073825597763, 0.07534481585025787, 0.039894215762615204, -0.007621324621140957, 0.025817422196269035, 0.10952557623386383, 0.10530972480773926, 0.11507976055145264, -0.034204546362161636 ]
pH\tis\tlow,\tranging\tfrom\tabout\t1\tto\t4.\tThe\tcombined\tactions\tof\thydrochloric\tacid\tand\tproteolytic\nenzymes\tresult\tin\ta\tsignificant\treduction\tin\tthe\tconcentration\tof\tviable\tmicroorganisms.\tSome\nmicrobes\tmay\tescape\tand\tenter\tthe\tintestine\tif\tconsumed\tin\tsufficient\tconcentrations\tor\tif\nachlorhydria,\tgastrectomy,\tgastrointestinal
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achlorhydria,\tgastrectomy,\tgastrointestinal\n\tdysfunction\tor\tdisease,\tpoor\tnutrition,\tor\tdrugs\tthat\nsuppress\tacid\tsecretions\tare\tpresent.\tThis\tmay\tincrease\tthe\trisk\tof\tpathogenic\tinfection\tin\tthe\nintestine.\nThe\tlower\tesophageal\tsphincter\t(LES),\twhich\tlies\tabove\tthe\tentrance\tto\tthe\tstomach,\tprevents
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reflux\tof\tgastric\tcontents\tinto\tthe\tesophagus.\tThe\tpyloric\tsphincter\tin\tthe\tdistal\tportion\tof\tthe\nstomach\thelps\tregulate\tthe\texit\tof\tgastric\n\tcontents,\tpreventing\tbackflow\tof\tchyme\tfrom\tthe\nduodenum\tinto\tthe\tstomach.\tObesity,\tcertain\tfood,\tgastrointestinal\tregulators,\tand\tirritation\tfrom
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nearby\tulcers\tmay\talter\tthe\tperformance\tof\tsphincters.\tCertain\tfoods\tand\tbeverages\tmay\talter\tLES\npressure,\tpermitting\treflux\tof\tstomach\tcontents\tback\tinto\tthe\tesophagus\t(see\t\nChapter\t26\n).\nThe\tstomach\tcontinuously\tmixes\tand\tchurns\tfood\tand\tnormally\treleases\n\tthe\tmixture\tin\tsmall
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0.04627746716141701, 0.04804219305515289, 0.04955769330263138, 0.09784556925296783, -4.1566142527926786e-8, -0.01735304296016693, -0.06823042035102844, 0.011907294392585754, -0.0003425988252274692, 0.04370837286114693, -0.023512572050094604, 0.1028183326125145, 0.06842242926359177, -0.021407335996627808, -0.05247171223163605, 0.019656436517834663, 0.12686647474765778, -0.08973190188407898, -0.042013365775346756, 0.08383502811193466, 0.03275671973824501, 0.007831537164747715, 0.049210187047719955, -0.012523473240435123, -0.03547375276684761, -0.03798910975456238, 0.09178376942873001, -0.02959548309445381, 0.05832713469862938, -0.01780453510582447, -0.008089845068752766, -0.0343502014875412, 0.02933533489704132, 0.044720932841300964, 0.04397258907556534, 0.07384122163057327, -0.03934754431247711, -0.0226936936378479, -0.042337629944086075, -0.013735341839492321, 0.08178913593292236, -0.06672179698944092, -0.04365026578307152, -0.010850774124264717, 0.10627586394548416, 0.03415369987487793, -0.0394446961581707, -0.04117891937494278, 0.07795025408267975, 0.0567537285387516, -0.05878853797912598, -0.02036353014409542, 0.05810447782278061, -0.009253580123186111, -0.07071713358163834, -0.03462536633014679, 0.12819622457027435, 0.01634281873703003, 0.013709229417145252, -0.059545889496803284, 0.011806253343820572, 0.05023957043886185, 0.012077328749001026, 0.035807181149721146, -0.01723182387650013, 0.043461501598358154, 0.11896348744630814, 0.047460444271564484, -0.016017818823456764 ]
the\tmixture\tin\tsmall\nquantities\tinto\tthe\tsmall\tintestine\tthrough\tthe\tpyloric\tsphincter.\tThe\tamount\temptied\twith\teach\ncontraction\tof\tthe\tantrum\tand\tpylorus\tvaries\twith\tthe\tvolume\tand\ttype\tof\tfood\tconsumed,\tbut\tonly\ta\nfew\tmilliliters\tare\treleased\tat\ta\ttime.\tThe\tpresence\tof\tacid\tand\tnutrients\tin\tthe\tduodenum\tstimulate
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0.03797772154211998, 0.033092133700847626, 0.06180946156382561, 0.07430810481309891, -4.5553839811418584e-8, -0.019793536514043808, -0.02503719925880432, -0.00770199578255415, -0.025471070781350136, 0.05193625018000603, -0.0028361703734844923, 0.08683710545301437, -0.017204659059643745, -0.03459963575005531, -0.053683385252952576, 0.03195251524448395, 0.07561889290809631, -0.08268631249666214, -0.03661935403943062, 0.06598901003599167, 0.05290962755680084, 0.001457430305890739, 0.06610167026519775, 0.016098476946353912, -0.0034422415774315596, 0.024976778775453568, 0.10216623544692993, -0.04822000488638878, -0.023051900789141655, -0.06712578237056732, 0.018395734950900078, -0.058597929775714874, 0.010728463530540466, -0.028077205643057823, 0.027408789843320847, 0.05746552348136902, -0.06140851974487305, -0.041041113436222076, -0.0723436176776886, -0.013100855983793736, 0.09042242914438248, -0.07625418156385422, -0.05506467819213867, 0.03952012211084366, 0.14516925811767578, 0.04250221699476242, 0.02069988287985325, -0.018234483897686005, 0.08292540162801743, 0.075895294547081, -0.059823695570230484, -0.04300733655691147, 0.04310429096221924, -0.023500947281718254, -0.07273390889167786, -0.028175165876746178, 0.11584483832120895, -0.03697313740849495, -0.031056607142090797, -0.02512868493795395, 0.013461434282362461, 0.06697683036327362, 0.03961899131536484, -0.06424218416213989, 0.010577330365777016, 0.07303553819656372, 0.08197791874408722, 0.07788093388080597, -0.004638246726244688 ]
the\tregulatory\thormone,\tGIP,\tto\tslow\tgastric\temptying.\nMost\tof\ta\tliquid\tmeal\tempties\n\tfrom\tthe\tstomach\twithin\t1\tto\t2\thours,\tand\tmost\tof\ta\tsolid\tmeal\nempties\twithin\t2\tto\t3\thours.\tWhen\teaten\talone,\tcarbohydrates\tleave\tthe\tstomach\tthe\tmost\trapidly,\nfollowed\tby\tprotein,\tfat,\tand\tfibrous\tfood.\tIn\ta\tmeal\twith\tmixed\ttypes\tof\tfoods,\temptying\tof\tthe
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stomach\tdepends\ton\tthe\toverall\tvolume\tand\tcharacteristics\tof\tthe\tfoods.\tLiquids\tempty\tmore\trapidly\nthan\tsolids,\tlarge\tparticles\tempty\tmore\n\tslowly\tthan\tsmall\tparticles,\tand\tenergy-dense\tfoods\tempty\nmore\tslowly\tthan\tthose\tcontaining\tless\tenergy.\tThese\tfactors\tare\timportant\tconsiderations\tfor
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practitioners\twho\tcounsel\tpatients\twith\tnausea,\tvomiting,\tdiabetic\tgastroparesis,\tor\tweight\nmanagement\tconcerns\t(see\t\nChapters\t26\n\tand\t\n20\n).
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Digestion\tin\tthe\tsmall\tintestine\nThe\tsmall\tintestine\tis\tthe\tprimary\tsite\tfor\tdigestion\tof\tfoods\tand\tnutrients.\n\tThe\tsmall\tintestine\tis\ndivided\tinto\tthe\tduodenum,\tthe\tjejunum,\tand\tthe\tileum\t(see\t\nFig.\t1.2\n).\tThe\tduodenum\tis\napproximately\t0.5\tm\tlong,\tthe\tjejunum\tis\t2\tto\t3\tm,\tand\tthe\tileum\tis\t3\tto\t4\tm.\tMost\tof\tthe\tdigestive
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process\tis\tcompleted\tin\tthe\tduodenum\tand\tupper\tjejunum,\tand\tthe\tabsorption\tof\tmost\tnutrients\tis\nlargely\tcomplete\tby\tthe\ttime\tthe\tmaterial\treaches\tthe\tmiddle\tof\tthe\tjejunum.\tThe\tacidic\tchyme\n\tfrom\nthe\tstomach\tenters\tthe\tduodenum,\twhere\tit\tis\tmixed\twith\tsecretions\tfrom\tthe\tpancreas,\tgallbladder,
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and\tduodenal\tepithelium.\tThe\tsodium\tbicarbonate\tcontained\twithin\tthese\tsecretions\tneutralizes\tthe\nacidic\tchyme\tand\tallows\tthe\tdigestive\tenzymes\tto\twork\tmore\teffectively\tat\tthis\tlocation.\nThe\tentry\tof\tpartially\tdigested\tfoods,\tprimarily\tfats\tand\tprotein,\tstimulates\tthe\trelease\tof\tCCK,\nsecretin,
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secretin,\n\tand\tGIP,\twhich,\tin\tturn,\tstimulate\tthe\tsecretion\tof\tenzymes\tand\tfluids\tand\taffect\ngastrointestinal\tmotility\tand\tsatiety.\tBile,\twhich\tis\tpredominantly\ta\tmixture\tof\twater,\tbile\tsalts,\tand\nsmall\tamounts\tof\tpigments\tand\tcholesterol,\tis\tsecreted\tfrom\tthe\tliver\tand\tgallbladder.\tThrough\ttheir
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surfactant\tproperties,\tthe\tbile\tsalts\tfacilitate\tthe\tdigestion\tand\tabsorption\tof\tlipids,\tcholesterol,\tand\nfat-soluble\n\tvitamins.\tBile\tacids\tare\talso\tregulatory\tmolecules;\tthey\tactivate\tthe\tvitamin\tD\treceptor\nand\tcell-signaling\tpathways\tin\tthe\tliver\tand\tGIT\tthat\talter\tgene\texpression\tof\tenzymes\tinvolved\tin\nthe\tregulation\tof\tenergy\tmetabolism\t(
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the\tregulation\tof\tenergy\tmetabolism\t(\nHylemon\tet\tal,\t2009\n).\tFurthermore,\tbile\tacids\tplay\tan\nimportant\trole\tin\thunger\tand\tsatiety.\nThe\tpancreas\tsecretes\tpotent\tenzymes\tcapable\tof\tdigesting\tall\tof\tthe\tmajor\tnutrients,\n\tand\tenzymes\nfrom\tthe\tsmall\tintestine\thelp\tcomplete\tthe\tprocess.\tThe\tprimary\tlipid-digesting\tenzymes\tsecreted\tby\nthe\tpancreas\tare
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the\tpancreas\tare\t\npancreatic\tlipase\n\tand\tcolipase.\tProteolytic\tenzymes\tinclude\ttrypsin\tand\nchymotrypsin,\tcarboxypeptidase,\taminopeptidase,\tribonuclease,\tand\tdeoxyribonuclease.\tTrypsin\tand\nchymotrypsin\tare\tsecreted\tin\ttheir\tinactive\tforms\tand\tare\tactivated\tby\tenterokinase\t(also\tknown\tas
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enteropeptidase),\twhich\tis\tbound\twithin\tthe\tbrush\tborder\tmembrane\tof\tenterocytes\twithin\tthe\tsmall\nintestine.\t\nPancreatic\tamylase\n\teventually\thydrolyzes\tlarge\tstarch\tmolecules\tinto\tunits\tof\napproximately\ttwo\tto\tsix\tsugars.\tDisaccharidase\tenzymes\tbound\tin\tthe\tenterocyte\tbrush\tborder
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membrane\tfurther\tbreak\tdown\tthe\tcarbohydrate\tmolecules\tinto\tmonosaccharides\tbefore\tabsorption.\nVarying\tamounts\tof\tresistant\n\tstarches\tand\tmost\tingested\tdietary\tfiber\tescape\tdigestion\tin\tthe\tsmall\nintestine\tand\tmay\tadd\tto\tfibrous\tmaterial\tavailable\tfor\tfermentation\tby\tcolonic\tmicrobes.
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Intestinal\tcontents\tmove\talong\tthe\tsmall\tintestine\tat\ta\trate\tof\tapproximately\t1\tcm\tper\tminute,\ntaking\tfrom\t3\tto\t8\thours\tto\ttravel\tthrough\tthe\tentire\tintestine\tto\tthe\tileocecal\tvalve;\talong\tthe\tway,\nremaining\tsubstrates\tcontinue\tto\tbe\n\tdigested\tand\tabsorbed.\tThe\tileocecal\tvalve,\tlike\tthe\tpyloric
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digested\tand\tabsorbed.\tThe\tileocecal\tvalve,\tlike\tthe\tpyloric\nsphincter,\tpaces\tthe\tentry\tof\tchyme\tinto\tthe\tcolon\tand\tlimits\tthe\tamount\tof\tmaterial\tpassed\tback\tand\nforth\tbetween\tthe\tsmall\tintestine\tand\tthe\tcolon.\tA\tdamaged\tor\tnonfunctional\tileocecal\tvalve\tresults
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in\tthe\tentry\tof\tsignificant\tamounts\tof\tfluid\tand\tsubstrate\tinto\tthe\tcolon\tand\tincreases\tthe\tchance\tfor\nmicrobial\tovergrowth\tin\tthe\tsmall\tintestine\n\t(see\t\nChapter\t26\n).\nThe\tsmall\tintestine:\tPrimary\tsite\tof\tnutrient\tabsorption\nThe\tprimary\torgan\tof\tnutrient\tand\twater\tabsorption\tis\tthe\tsmall\tintestine,\twhich\thas\tan\texpansive
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0.09638817608356476, -0.02861100621521473, -0.02429073676466942, -0.01912902109324932, 0.07332085072994232, 0.05642132833600044, -0.07958285510540009, -0.0052527873776853085, 0.07808861136436462, 0.0060556428506970406, -0.06685051321983337, -0.011515689082443714, 0.10234890133142471, -0.01794602908194065, -0.022906892001628876, -0.047673922032117844, 0.016607554629445076, 0.050464071333408356, 0.034030720591545105, -0.03280927985906601, 0.000711676140781492, 0.017909342423081398, 0.05858028680086136, 0.0826214998960495, -0.02702363207936287 ]
absorptive\tarea.\tThe\tsurface\tarea\tis\tattributable\tto\tits\textensive\tlength,\tas\twell\tas\tto\tthe\norganization\tof\tthe\tmucosal\tlining,\twherein\tthere\tare\tcharacteristic\tfolds\tin\tits\tmucosal\tsurface\tthat\nare\tcovered\twith\tfingerlike\n\tprojections\tcalled\tvilli\tand\tinvaginations\tcalled\tcrypts\t(see\t\nFig.\t1.2\n).
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Fig.\t1.2\n).\nEnterocytes,\ta\tcell\ttype\tthat\tdoes\tmuch\tof\tthe\tdigestion\tand\tabsorption\tare\tcovered\tby\tmicrovilli,\tor\nthe\t\nbrush\tborder\tmembrane\n,\twhich\tincreases\tthe\tsurface\tarea\teven\tfurther.\tThe\tcombination\tof\nfolds,\tthe\tcrypt-villus\taxis,\tand\tthe\tbrush\tborder\tmembrane\tcreates\tan\tenormous\tabsorptive\tsurface\nof\tapproximately\t200\tto\t300\tm\n2
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Each\tday,\ton\taverage,\tthe\tsmall\tintestine\tabsorbs\t150\tto\t300\tg\tof\tmonosaccharides,\t60\tto\t100\tg\tof\nfatty\tacids,\t60\tto\t120\tg\tof\tamino\tacids\n\tand\tpeptides,\tand\t50\tto\t100\tg\tof\tions.\tThe\tcapacity\tfor\nabsorption\tin\tthe\thealthy\tindividual\tfar\texceeds\tthe\tnormal\tmacronutrient\tand\tenergy\trequirements.
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Approximately\t95%\tof\tthe\tbile\tsalts\tsecreted\tfrom\tthe\tliver\tand\tgallbladder\tare\treabsorbed\tas\tbile\nacids\tin\tthe\tdistal\tileum.\tWithout\trecycling\tbile\tacids\tfrom\tthe\tGIT\t(enterohepatic\tcirculation),\nsynthesis\tof\tnew\tbile\tacids\tin\tthe\tliver\twould\n\tnot\tkeep\tpace\twith\tneeds\tfor\tadequate\tdigestion.\tBile
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not\tkeep\tpace\twith\tneeds\tfor\tadequate\tdigestion.\tBile\nsalt\tinsufficiency\tbecomes\tclinically\timportant\tin\tpatients\twho\thave\tresections\tof\tthe\tdistal\tsmall\nbowel\tand\tdiseases\taffecting\tthe\tsmall\tintestine,\tsuch\tas\tCrohn’s\tdisease,\tradiation\tenteritis,\tand\ncystic\tfibrosis.\tThe\tdistal\tileum\tis\talso\tthe\tsite\tfor\tvitamin\tB\n12
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cystic\tfibrosis.\tThe\tdistal\tileum\tis\talso\tthe\tsite\tfor\tvitamin\tB\n12\n\t(with\tintrinsic\tfactor)\tabsorption.\nAbsorptive\tand\ttransport\tmechanisms\nAbsorption\tis\ta\tcomplex\tprocess\tinvolving\tmany\tdistinct\tpathways\tfor\tspecific\tnutrients\tand/or\tions.\nHowever,\tthe\ttwo\tbasic\ttransport\tmechanisms\tused\tare\tpassive\tand\tactive\ttransport.\tThe\tprimary
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does\tnot\trequire\tenergy,\tand\tnutrients\tmove\tfrom\ta\tlocation\tof\thigh\nconcentration\tto\tlow\tconcentration.\tWith\tpassive\ttransport\ta\ttransport\tprotein\tmay\tor\tmay\tnot\tbe\ninvolved.\tIf\tthe\tnutrient\tmoves\tthrough\tthe\tbrush\tborder\tmembrane\twithout\ta\ttransport\tprotein,\tthis\nis\ttermed\t\npassive\tdiffusion\n,\tor\tsimple\tpassive\ttransport.\tHowever,\tin\tcases\tin
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passive\tdiffusion\n,\tor\tsimple\tpassive\ttransport.\tHowever,\tin\tcases\tin\n\twhich\ta\ttransport\nprotein\tassists\tthe\tpassage\tof\tthe\tnutrient\tacross\tthe\tbrush\tborder\tmembrane,\tthis\tprocess\tis\ttermed\nfacilitated\tdiffusion\n\t(\nFig.\t1.4\n).
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0.0144503740593791, -0.0281259473413229, -0.02253725193440914, 0.04727204144001007, 0.11411961168050766, -0.013028536923229694, 0.03160332888364792, 0.06607948243618011, -0.0068519762717187405, -0.04909951239824295, 0.0028844692278653383, 0.07710303366184235, 0.01824505440890789, -0.04897891730070114, -0.06191990524530411, 0.04252251237630844, 0.0486222468316555, 0.02158556878566742, -0.0511997826397419, -0.009506662376224995, 0.040770869702100754, 0.1048281192779541, 0.10896772146224976, 0.015118621289730072 ]
FIG.\t1.4\nTransport\tpathways\tthrough\tthe\tcell\tmembrane,\tas\twell\tas\tbasic\ttransport\tmechanisms.\t\nATP,\nAdenosine\ttriphosphate.\nActive\ttransport\n\tis\tthe\tmovement\tof\tmolecules\tacross\tcell\tmembranes\tin\tthe\tdirection\tagainst\ntheir\tconcentration\tgradient\tand\ttherefore\trequires\ta\ttransporter\tprotein\tand\tenergy\tin\tthe\tform\tof
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ATP.\tSome\tnutrients\tmay\tshare\tthe\tsame\ttransporter\tand\tthus\tcompete\tfor\tabsorption.\n\tTransport\tor\ncarrier\tsystems\talso\tcan\tbecome\tsaturated,\tslowing\tthe\tabsorption\tof\tthe\tnutrient.\tA\tnotable\nexample\tof\tsuch\ta\tcarrier\tis\tintrinsic\tfactor,\twhich\tis\tresponsible\tfor\tthe\tabsorption\tof\tvitamin\tB\n12\n(see\t\nChapter\t26\n).\nThe\tlarge\tintestine
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12\n(see\t\nChapter\t26\n).\nThe\tlarge\tintestine\nThe\tlarge\tintestine\tis\tapproximately\t1.5\tm\tlong\tand\tconsists\tof\tthe\tcecum,\tcolon,\trectum,\tand\tanal\ntract.\tMucus\tsecreted\tby\tthe\tmucosa\tof\tthe\tlarge\n\tintestine\tprotects\tthe\tintestinal\twall\tfrom\nexcoriation\tand\tbacterial\tactivity\tand\tprovides\tthe\tmedium\tfor\tbinding\tthe\tfeces\ttogether.
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-0.04587223380804062, -0.02733275666832924, -0.07114780694246292, 0.05254806950688362, 0.08837414532899857, -0.036295901983976364, -0.02741355635225773, -0.037791457027196884, 0.04951901361346245, -0.025190912187099457, 0.02739478461444378, -0.1030188724398613, -0.05173744261264801, 0.018835563212633133, 0.029281603172421455, -0.0027583844494074583, 0.03157421946525574, -0.009550820104777813, 0.049787119030952454, -0.03749595582485199, -0.06908997893333435, 0.0382135845720768, 0.008559055626392365, -0.037629690021276474, 0.002697971183806658, 0.030392741784453392, -0.11445049196481705, -0.1306910514831543, 0.027877982705831528, -0.08354082703590393, 0.014032047241926193, -0.05835648998618126, -0.0407869778573513, 0.008683469146490097, -0.053095318377017975, -0.029592080041766167, 0.010964185930788517, 0.044643379747867584, 0.00430615758523345, -0.045656848698854446, 0.012025675736367702, 0.05393589287996292, 0.043646760284900665, 0.10755795240402222, -0.02822553738951683, 0.03695770353078842, -0.0004526045231614262, 0.03603218495845795, 0.07392890006303787, -4.593032087996107e-8, 0.004197254311293364, -0.03723285719752312, -0.022844986990094185, -0.045849889516830444, 0.04847266152501106, -0.011396771296858788, 0.021684395149350166, 0.036820292472839355, -0.002812385791912675, -0.08413548022508621, 0.023827165365219116, 0.09055603295564651, -0.07677919417619705, -0.03182921186089516, 0.04863112419843674, 0.025831062346696854, 0.022289857268333435, 0.044448744505643845, -0.01118038035929203, -0.06189792975783348, 0.01942647248506546, 0.0855373963713646, 0.01961984485387802, -0.016330866143107414, -0.05146143212914467, 0.026539376005530357, -0.020417410880327225, 0.009776527993381023, -0.003411669284105301, 0.008436125703155994, 0.05480891466140747, -0.03789432346820831, -0.029027767479419708, -0.03808833286166191, -0.03690536320209503, 0.07088297605514526, -0.025242885574698448, -0.029843561351299286, 0.011226208880543709, 0.12530407309532166, -0.014499571174383163, -0.04259004816412926, -0.028742237016558647, 0.09033577144145966, 0.030862415209412575, -0.08887866139411926, -0.03556804731488228, 0.039755482226610184, -0.02464742586016655, -0.10347417742013931, -0.02915196120738983, 0.1107681393623352, 0.008787959814071655, -0.03844989836215973, -0.08964178711175919, 0.052803993225097656, 0.09308944642543793, 0.022030116990208626, -0.021318728104233742, 0.021858982741832733, 0.07618976384401321, 0.08346083015203476, 0.08142759650945663, -0.004367146175354719 ]
Approximately\t2\tL\tof\tfluids\tare\ttaken\tfrom\tfood\tand\tbeverages\tduring\tthe\tday,\tand\t7\tL\tof\tfluid\tis\nsecreted\talong\tthe\tGIT.\tUnder\tnormal\tcircumstances,\tmost\tof\tthat\tfluid\tis\tabsorbed\tin\tthe\tsmall\nintestine,\tand\tapproximately\t2\tL\tof\tfluid\tenters\tthe\tlarge\tintestine.\n\tAll\tbut\t100\tto\t150\tmL\tof\tthis\tfluid
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0.051119349896907806, -0.03868899121880531, -0.040852028876543045, -0.050120990723371506, -0.03988911956548691, -0.04295025393366814, 0.01220579445362091, -0.06926203519105911, 0.051845524460077286, 0.015240627340972424, -0.004573331214487553, -0.05881507322192192, -0.08081633597612381, -0.0007617746596224606, 0.00615004962310195, 0.01637897826731205, 0.021629836410284042, -0.03351648896932602, 0.033292874693870544, 0.04151592776179314, 0.031934380531311035, -0.0003867011982947588, 0.0055739618837833405, 0.03829331323504448, -0.014836552552878857, -0.02895165979862213, 0.050592780113220215, -0.044667474925518036, 0.11531689763069153, -0.005393619183450937, 0.07213757932186127, 0.0423540361225605, 0.024181872606277466, -0.024800220504403114, -0.06944891810417175, -0.09484102576971054, 0.09840144962072372, 0.03870690241456032, 0.008156307972967625, -0.028249641880393028, 0.04905441030859947, 0.003381232963874936, 0.07592025399208069, 0.03852052986621857, 0.004364475607872009, 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-0.011699945665895939, -0.04389095678925514, 0.04730851575732231, -0.02420671470463276, -0.016176674515008926, 0.037595946341753006, 0.07055163383483887, 0.02598586492240429, -0.05093995854258537, 0.08815346658229828, 0.0750090703368187, -0.01017233356833458, -0.13232570886611938, 0.008258333429694176, 0.05365191400051117, -0.026273630559444427, 0.006744211073964834, -0.028922058641910553, 0.009115630760788918, -0.07268189638853073, 0.025798512622714043, -0.10289767384529114, 0.051062844693660736, -0.008691451512277126, 0.09362044930458069, 0.014621414244174957, -0.007916074246168137, 0.006466730032116175, 0.05796216428279877, 0.04888472333550453, -0.07249771058559418, 0.00277144368737936, 0.07336308062076569, -0.024453885853290558, -0.029333291575312614, 0.080946184694767, 0.0035265570040792227, -0.06800796836614609, -0.015433823689818382, 0.054403841495513916, -0.0010295961983501911, 0.04776729270815849, -0.022312358021736145, -0.01260772068053484, 0.04576179012656212, -0.034587472677230835, -0.08727815002202988, -0.003007796360179782, 0.020275600254535675, 0.052156493067741394, -0.03983054682612419, 0.0271533764898777, 0.010204063728451729, 0.053246017545461655, -0.01871444843709469, -0.01189378835260868, -0.01538025587797165, -0.03227147459983826, -0.012385856360197067, 0.06221821531653404, -0.07229280471801758, 0.10553721338510513, -0.007101882249116898, 0.020173361524939537, -0.0441221259534359, -0.040005169808864594, -0.017379654571413994, -0.047970619052648544, -0.027920108288526535, 0.0056805056519806385, 0.013574169017374516, -0.057650044560432434, -0.1247992292046547, 0.05220022797584534, -0.08421972393989563, 0.08281257748603821, -0.041923556476831436, -0.018211256712675095, -0.03226229548454285, -0.03470546379685402, 0.027978455647826195, 0.03364597260951996, 0.01673138327896595, 0.06037938594818115, -0.06361664086580276, 0.012306241318583488, -0.0014183500315994024, 0.06211578845977783, 0.06867457926273346, -0.004126200918108225, 0.07121273875236511, 0.04344779998064041, 0.059362150728702545, 0.07581154257059097, -4.646154039278372e-8, 0.032866328954696655, -0.05196445435285568, 0.009921652264893055, 0.0070644887164235115, 0.020287729799747467, 0.00030830371542833745, 0.060532521456480026, 0.06509120017290115, -0.03890618309378624, -0.08038680255413055, 0.07323479652404785, 0.04597284272313118, -0.04584017023444176, -0.05173834413290024, 0.1351698338985443, 0.02880752831697464, -0.057296983897686005, 0.044750433415174484, -0.04721591994166374, -0.06235421448945999, -0.022853130474686623, 0.13148878514766693, 0.024191532284021378, -0.033557772636413574, -0.019254449754953384, 0.03016723319888115, -0.02676950767636299, -0.020236145704984665, 0.05626764893531799, -0.0006147875101305544, 0.03665044531226158, -0.05064738914370537, 0.06040768697857857, -0.005578047130256891, 0.01615568995475769, 0.10307153314352036, -0.08568151295185089, 0.01511202473193407, 0.0010510165011510253, 0.08500300347805023, -0.06720642745494843, -0.014710323885083199, -0.04701879620552063, 0.05234599858522415, 0.06686408817768097, -0.03261476010084152, -0.07168658822774887, 0.09329281002283096, -0.00822534877806902, -0.038055744022130966, -0.0199456624686718, 0.08668623119592667, 0.009870847687125206, -0.0049337418749928474, -0.05221923440694809, 0.017299333587288857, -0.015964679419994354, 0.023951426148414612, -0.00359707442112267, -0.010582014918327332, 0.018302254378795624, 0.049696069210767746, 0.05641806125640869, -0.028880394995212555 ]
All\tbut\t100\tto\t150\tmL\tof\tthis\tfluid\nis\tabsorbed;\tthe\tremainder\tis\texcreted\tin\tthe\tfeces.\nThe\tlarge\tintestine\tis\talso\tthe\tsite\tof\tbacterial\tfermentation\tof\tremaining\tcarbohydrates\tand\tamino\nacids,\tsynthesis\tof\ta\tsmall\tamount\tof\tvitamins\t(particularly\tvitamin\tK),\tstorage,\tand\texcretion\tof\tfecal
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residues.\tColonic\tcontents\tmove\tforward\tslowly\tat\ta\trate\tof\t5\tcm/h,\tand\tsome\tremaining\tnutrients\nmay\n\tbe\tabsorbed.\nDefecation,\tor\texpulsion\tof\tfeces\tthrough\tthe\trectum\tand\tanus,\toccurs\twith\tvarying\tfrequency,\nranging\tfrom\tthree\ttimes\tdaily\tto\tonce\tevery\t3\tor\tmore\tdays.\tAverage\tstool\tweight\tranges\tfrom\t100
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to\t200\tg,\tand\tmouth-to-anus\ttransit\ttime\tmay\tvary\tfrom\t18\tto\t72\thours.\tThe\tfeces\tgenerally\tconsist\nof\t75%\twater\tand\t25%\tsolids,\tbut\tthe\tproportions\tvary\tgreatly.\tApproximately\ttwo-thirds\tof\n\tthe\ncontents\tof\tthe\twet\tweight\tof\tthe\tstool\tis\tbacteria,\twith\tthe\tremainder\tcoming\tfrom\tgastrointestinal
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secretions,\tmucus,\tsloughed\tcells,\tmicrobiota,\tand\tundigested\tfoods.\tA\tdiet\tthat\tincludes\tabundant\nfruits,\tvegetables,\tlegumes,\tand\twhole\tgrains\ttypically\tresults\tin\ta\tshorter\toverall\tGIT\ttransit\ttime,\nmore\tfrequent\tdefecation,\tand\tlarger\tand\tsofter\tstools.\nIntestinal\tmicrobiota:\tThe\tmicrobiome\nThe\tintestinal\t\nmicrobiota\n,\talso\tcalled\tthe
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The\tintestinal\t\nmicrobiota\n,\talso\tcalled\tthe\t\nmicrobiome\n,\tis\ta\tdynamic\tmixture\tof\tessential\tmicrobes\nthat\tdevelops\tunder\tkey\tinfluences\tof\tgenetics,\tenvironment,\tdiet,\tand\tdisease.\tBacterial\tpopulation\nprofiles\tdiffer\talong\tthe\tgastrointestinal\ttract,\tfrom\tthe\tlumen\tto\tthe\tmucosa,\tand\tamong\tindividuals.
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The\ttotal\tmicrobiota\tpopulation\toutnumbers\tthe\tcells\tin\tthe\thuman\tbody\tby\ta\tfactor\tof\t10\tand\naccounts\n\tfor\t35%\tto\t50%\tof\tthe\tvolume\tof\tthe\tcolonic\tcontent.\tKey\tphysiologic\tfunctions\tof\tthe\ncommensal\tmicrobiota\tinclude\t(1)\tprotective\teffects\texerted\tdirectly\tby\tspecific\tbacterial\tspecies,\t(2)
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0.003967751748859882, -0.014245744794607162, -0.09812039136886597, 0.12633731961250305, 0.08340630680322647, -0.03598769009113312, -0.05795896053314209, 0.08213222026824951, -0.014412905089557171, -0.07318276911973953, -0.05669324845075607, 0.1083233579993248, -0.014315598644316196, 0.03182803839445114, -0.14086900651454926, 0.01696033589541912, 0.05581451579928398, 0.031214486807584763, 0.028470702469348907, 0.019755113869905472, 0.03898615390062332, 0.10346352308988571, 0.07832780480384827, -0.03983169049024582 ]
control\tof\tepithelial\tcell\tproliferation\tand\tdifferentiation,\t(3)\tproduction\tof\tessential\tmucosal\nnutrients,\tsuch\tas\tshort-chain\tfatty\tacids\tand\tamino\tacids,\t(4)\tprevention\tof\tovergrowth\tof\npathogenic\torganisms,\n\t(5)\tstimulation\tof\tintestinal\timmunity,\tand\t(6)\tdevelopment\tof\tthe\tgut-brain\naxis\t(\nKostic\tet\tal,\t2014\n;\tsee\t\nChapter\t40
[ -0.04100116714835167, -0.08590295165777206, 0.010670460760593414, -0.01129069458693266, -0.06379347294569016, 0.0546250157058239, 0.0215713232755661, 0.045601505786180496, 0.010593417100608349, 0.12205339223146439, 0.14002865552902222, -0.040535226464271545, 0.03443237766623497, 0.0379771888256073, -0.05321585386991501, 0.01566832698881626, -0.07076409459114075, 0.0022931613493710756, -0.030042659491300583, -0.03166907653212547, -0.0021492568776011467, 0.08522256463766098, -0.0022010013926774263, -0.008692237548530102, -0.045124705880880356, -0.05014816299080849, -0.0431208498775959, -0.024893244728446007, -0.029771044850349426, -0.05541776865720749, -0.11170174181461334, 0.04013260453939438, -0.08783731609582901, -0.025748077780008316, 0.01895279996097088, 0.006147558335214853, -0.07551717758178711, 0.0011536480160430074, 0.06910791993141174, 0.02941018156707287, 0.03764307498931885, -0.08576716482639313, -0.07319934666156769, -0.021936241537332535, 0.07398286461830139, 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-0.00023231255181599408, 0.1374947428703308, -0.042699042707681656, -0.025941912084817886, -0.05698387697339058, 0.07219921052455902, 0.0405200831592083, -0.02552117221057415, -0.02575145848095417, 0.0829053446650505, -0.005488335620611906, -0.09557685256004333, -0.019852418452501297, 0.07166953384876251, -0.028006982058286667, -0.035605624318122864, -0.08295547962188721, 0.02332151122391224, 0.08704753965139389, -0.009129298850893974, 0.028479721397161484, -0.016527922824025154, -0.0022387744393199682, 0.10343779623508453, 0.10607562214136124, -0.024390514940023422 ]
axis\t(\nKostic\tet\tal,\t2014\n;\tsee\t\nChapter\t40\n).\tReduced\tabundance\tor\tchanges\tin\tthe\trelative\tproportions\nof\tthese\tbeneficial\tbacteria,\ta\tstate\tcalled\t\ndysbiosis\n,\tis\tassociated\twith\tvarious\tdiseases\tin\tboth\nchildren\tand\tadults\t(\nBuccigrossi\tet\tal,\t2013\n;\t\nFig.\t1.5\n).
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FIG.\t1.5\nFactors\taffecting\tstability\tand\tcomplexity\tof\tintestinal\tmicrobiota\tin\thealth\tand\tdisease.\n\t\nSource:\n(Redrawn\tfrom\tKostic\tAD\tet\tal:\tThe\tmicrobiome\tin\tinflammatory\tbowel\tdisease:\tcurrent\tstatus\tand\tthe\tfuture\tahead,\nGastroenterology\n\t146:1489,\t2014.)
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Gastroenterology\n\t146:1489,\t2014.)\nNormally,\trelatively\tfew\tbacteria\tremain\tin\tthe\tstomach\tand\tproximal\tsmall\tintestine\tafter\tmeals\nbecause\tbile,\thydrochloric\tacid,\tand\tpepsin\n\twork\tas\tgermicides.\tHowever,\tdecreased\tgastric\nsecretions\tcan\tincrease\tthe\trisk\tof\tinflammation\tof\tthe\tgastric\tmucosa\t(gastritis),\tincrease\tthe\trisk\tof
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bacterial\tovergrowth\tin\tthe\tsmall\tintestine,\tor\tincrease\tthe\tnumbers\tof\tmicrobes\treaching\tthe\tcolon.\nAn\tacid-tolerant\tbacterium\tis\tknown\tto\tinfect\tthe\tstomach\t(Helicobacter\tpylori)\tand\tmay\tcause\ngastritis\tand\tulceration\tin\tthe\thost\t(see\t\nChapter\t26\n).
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gastritis\tand\tulceration\tin\tthe\thost\t(see\t\nChapter\t26\n).\nBacterial\tabundance\tis\tthe\tgreatest\tand\taction\tis\tmost\tintense\tin\tthe\tdistal\tsmall\tintestine\tand\tthe\nlarge\tintestine.\tAfter\ta\tmeal,\tdietary\tfiber,\tresistant\tstarches,\tremaining\tparts\tof\tamino\tacids,\tand\nmucus\tsloughed\tfrom\tthe\tintestine\tare\tfermented\tby\tthe\tmicrobes\tpresent.\tThis\tprocess\tof
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fermentation\tproduces\tgases\t(e.g.,\thydrogen,\tcarbon\tdioxide,\tnitrogen,\tand,\tin\tsome\tindividuals,\nmethane)\n\tand\tSCFAs\t(e.g.,\tacetic,\tpropionic,\tbutyric,\tand\tsome\tlactic\tacids).\tDuring\tthe\tprocess,\nseveral\tnutrients\tare\tformed\tby\tbacterial\tsynthesis,\tsuch\tas\tvitamin\tK,\tvitamin\tB\n12\n,\tthiamin,\tand\nriboflavin.
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12\n,\tthiamin,\tand\nriboflavin.\nStrategies\tto\tstabilize\tand\tfortify\tthe\tbeneficial\tmicrobes\twithin\tthe\tmicrobiota\tin\tan\tattempt\tto\nmaintain\tor\timprove\thealth\tinclude\tthe\tconsumption\tof\tprebiotics,\tprobiotics,\tand\tsynbiotics.\nProbiotics\n\tare\tlive\tmicroorganisms,\twhich,\twhen\tadministered\tin\tadequate\tamounts,\tprovide\ta
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health\tbenefit\tto\tthe\thost.\tProbiotics\tcan\tbe\tfound\twithin\tfermented\tfood\tproducts\t(such\tas\tyogurt,\nmiso,\tor\tsauerkraut)\tor\tas\ta\tnutritional\tsupplement\t(\nHill\tet\tal,\t2014\n).\tKnowledge\tof\ttheir\trole\tin\npreventing\tand\ttreating\ta\thost\tof\tgastrointestinal\tand\tsystemic\tdisorders\thas\texpanded\ntremendously\tin\trecent\tyears\t(\nFloch,\t2018
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tremendously\tin\trecent\tyears\t(\nFloch,\t2018\n).\tHowever,\twhen\trecommending\ta\tprobiotic,\tpractitioners\nmust\tensure\tthat\tthe\tspecific\tmicrobial\tspecies\thas\tbeen\tshown\tin\tproperly\tcontrolled\tstudies\tto\nprovide\tbenefits\tto\thealth\t(see\t\nChapter\t11\n).\nPrebiotics\n\tare\tnondigestible\tfood\tingredients\tthat\tact\tas\ta\tsubstrate\tthat\tis\tselectively\tutilized\tby
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host\tmicroorganisms\tconferring\ta\thealth\tbenefit.\tPrebiotics\ttypically\trequire\tthe\tfollowing\tthree\nattributes\tto\tbenefit\t“beneficial”\tmicrobes,\tsuch\tas\t\nLactobacilli\n\tand\t\nBifidobacteria\n\tspp.:\t(1)\tbe\table\tto\nescape\tdigestion\tin\tthe\tupper\tGIT,\t(2)\tbe\table\tto\tbe\tfermented\tby\tthe\tmicrobiota\tto\tSCFA(s),\tand\t(3)
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be\table\tto\tincrease\tthe\tabundance\tand/or\trelative\tproportion\tof\tbacteria\tknown\tto\tcontribute\tto\nhuman\thealth.\tGood\tdietary\tsources\tof\tprebiotic\tcarbohydrates\tinclude\tvegetables\t(including\tonions,\ngarlic,\tand\tasparagus),\tfruits\t(especially\tbananas,\tapples,\tstone\tfruits,\tand\tmangos),\tgrains,\tlegumes,
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chicory,\tJerusalem\tartichokes,\tsoybeans,\tand\twheat\tbran.\tStrong\tevidence\texists\tthat\tconsumption\tof\nspecific\tprebiotics\tbenefits\tthe\tGIT\tincluding\tinhibition\tof\tpathogens\tand\timmune\tstimulation,\ncardiometabolic\tsupport\t(e.g.,\treduction\tin\tblood\tlipid\tlevels,\teffects\tupon\tinsulin\tresistance),\n\tmental
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mental\nhealth\tbenefits\t(e.g.,\tmetabolites\tthat\tinfluence\tbrain\tfunction,\tenergy,\tand\tcognition)\tand\tbone\nhealth\t(e.g.,\tmineral\tbioavailability)\t(\nGibson\tet\tal,\t2017\n).\nSynbiotics\n\tare\ta\tsynergistic\tcombination\tof\tboth\tprobiotics\tand\tprebiotics\tin\tthe\tsame\tfood\tor\nsupplement.
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0.08512594550848007, -0.004961020313203335, 0.003173084696754813, -0.0870477706193924, 0.05903355032205582, 0.03126092627644539, -0.0767577737569809, -0.05387526750564575, 0.0884752869606018, -0.03593919798731804, -0.0719391480088234, 0.053064584732055664, 0.1316273957490921, 0.005237479694187641, -0.005139592103660107, -0.06242934986948967, 0.05473305657505989, 0.09956062585115433, -0.03470401093363762, 0.008876124396920204, -0.020676104351878166, 0.045816462486982346, 0.06151024252176285, 0.11664790660142899, -0.02007836289703846 ]
supplement.\nColonic\tsalvage\tof\tmalabsorbed\tenergy\tsources\tand\tshort-chain\tfatty\tacids\nNormally,\tvarying\tamounts\tof\tsome\tsmall-molecular-weight\n\tcarbohydrates\tand\tamino\tacids\tremain\tin\nthe\tchyme\tafter\tleaving\tthe\tsmall\tintestine.\tAccumulation\tof\tthese\tsmall\tmolecules\tcould\tbecome
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osmotically\timportant\twere\tit\tnot\tfor\tthe\taction\tof\tbacteria\tin\tthe\tcolon.\tThe\tdisposal\tof\tresidual\nsubstrates\tthrough\tproduction\tof\tSCFAs\tis\tcalled\t\ncolonic\tsalvage\n.\tSCFAs\tproduced\tin\tfermentation\nare\trapidly\tabsorbed\tand\ttake\twater\twith\tthem.\tThey\talso\tserve\n\tas\tfuel\tfor\tthe\tcolonocytes\tand\tthe
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The\tability\tto\tsalvage\tcarbohydrates\tis\tlimited\tin\thumans.\tColonic\tfermentation\tnormally\n\tdisposes\nof\t20\tto\t25\tg\tof\tcarbohydrates\tover\t24\thours.\tExcess\tamounts\tof\tcarbohydrates\tand\tfermentable\nfiber\tin\tthe\tcolon\tcan\tcause\tincreased\tgas\tproduction,\tabdominal\tdistention,\tbloating,\tpain,
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Digestion\tand\tabsorption\tof\tspecific\ttypes\tof\tnutrients\nCarbohydrates\n\tand\tfiber\nMost\tdietary\tcarbohydrates\tare\tconsumed\tin\tthe\tform\tof\tstarches,\tdisaccharides,\tand\nmonosaccharides.\tStarches,\tor\tpolysaccharides,\tusually\tmake\tup\tthe\tgreatest\tproportion\tof\ncarbohydrates.\tStarches\tare\tlarge\tmolecules\tcomposed\tof\tstraight\tor\tbranched\tchains\tof\tsugar
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0.01772915944457054, -0.061744023114442825, -0.017817843705415726, -0.0024071342777460814, -0.04713689908385277, -0.07513424754142761, -0.006861006375402212, -0.12746964395046234, 0.060266733169555664, 0.04937922954559326, -0.03341124206781387, -0.021143503487110138, -0.05107889696955681, -0.030784858390688896, -0.013037861324846745, 0.023744232952594757, -0.016701728105545044, -0.04494824260473251, 0.021419567987322807, 0.02817915938794613, 0.008936142548918724, 0.0005951031344011426, 0.01075806189328432, 0.009501487016677856, 0.04496264457702637, -0.09810738265514374, 0.01181947160512209, -0.040256500244140625, 0.12255757302045822, -0.029805375263094902, 0.07278164476156235, 0.0665740892291069, 0.00008304064976982772, -0.03110976703464985, -0.074912428855896, -0.07976506650447845, 0.12148720771074295, 0.05903597176074982, 0.04707125946879387, -0.029776226729154587, 0.011019413359463215, -0.04398559033870697, 0.07506758719682693, 0.04331231489777565, -0.032450269907712936, 0.0053504453971982, -0.05172441899776459, 0.07122273743152618, -0.030665047466754913, -0.08134337514638901, -0.027074849233031273, 0.06191452965140343, -0.07156462222337723, 0.04059906303882599, -0.02323385886847973, -0.020852137356996536, -0.0007660572300665081, 0.05736194923520088, -0.059953730553388596, -0.07088825106620789, -0.007733061909675598, -0.032356858253479004, -0.02919858880341053, 0.07505297660827637, -0.008018868044018745, -0.034431491047143936, 0.020935434848070145, 0.03376659005880356, -0.0515865720808506, -0.05867651849985123, -0.00881839171051979, -0.04160089045763016, -0.0411437451839447, 0.07806690037250519, 0.025307511910796165, -0.013656824827194214, -0.04212552309036255, 0.07227768003940582, 0.0785662829875946, -0.07011909037828445, -0.015615817159414291, -0.02376193180680275, 4.2009413033503816e-33, 0.004832992795854807, -0.006176132708787918, 0.06258408725261688, 0.022310687229037285, 0.004851902835071087, -0.01853329688310623, -0.014593422412872314, 0.0016581063391640782, -0.019754942506551743, 0.07675541937351227, -0.09307761490345001, 0.002293144818395376, -0.03793957829475403, 0.0977446660399437, 0.00011066424485761672, -0.027548639103770256, -0.04511009901762009, 0.015329387970268726, 0.0050669945776462555, -0.023650135844945908, -0.07648962736129761, 0.1774599403142929, 0.05983281880617142, -0.03684312850236893, 0.015442503616213799, -0.018947264179587364, -0.00817518774420023, -0.026095693930983543, -0.011023951694369316, 0.0072990721091628075, 0.08781147748231888, -0.09400945901870728, -0.028402049094438553, 0.027619618922472, 0.00015801520203240216, -0.025368832051753998, -0.028459714725613594, 0.01831204630434513, 0.010297499597072601, 0.005719984415918589, -0.04102426767349243, -0.00414557009935379, 0.012905766256153584, 0.031659454107284546, 0.021417904645204544, -0.02065177634358406, -0.030668841674923897, -0.003041682532057166, -0.01253493782132864, -0.0008905839640647173, 0.01926787570118904, 0.020548459142446518, 0.06993146240711212, 0.010514129884541035, -0.08214631676673889, -0.008479991927742958, 0.025610722601413727, 0.003924499731510878, -0.05401434004306793, 0.12642517685890198, -0.04563209414482117, 0.08874094486236572, 0.03164403513073921, -0.05339038744568825, -0.0008208995568566024, -0.011158006265759468, -0.14761173725128174, -0.020865561440587044, 0.02723037451505661, 0.012561525218188763, -0.0856168121099472, -0.011603014543652534, 0.04116862267255783, 0.08650397509336472, 0.057079017162323, -0.051023926585912704, 0.01761128008365631, -0.08566995710134506, -0.038791634142398834, -0.040339209139347076, -0.020062332972884178, -0.062180645763874054, -0.01902814209461212, -0.026183973997831345, -0.1253475397825241, 0.0046443454921245575, 0.013390281237661839, -0.07085859775543213, 0.013194463215768337, -0.022417470812797546, -0.03282041847705841, 0.0730477049946785, -0.004078440368175507, -0.07170292735099792, -0.07359579205513, -5.4936309715817126e-33, 0.013113410212099552, -0.019701920449733734, -0.04527387022972107, 0.03154143691062927, -0.03758959844708443, -0.03958379104733467, 0.018144378438591957, 0.00054727349197492, 0.023697277531027794, -0.04628300666809082, 0.1123092845082283, 0.06912799179553986, -0.0041273501701653, -0.0985613465309143, 0.02247771993279457, 0.09950127452611923, 0.012357322499155998, 0.08268208801746368, -0.008344199508428574, -0.0024850214831531048, -0.0934571623802185, 0.013812005519866943, -0.0697522982954979, 0.040391381829977036, 0.02505507320165634, 0.051507312804460526, 0.04383207857608795, 0.006237605586647987, 0.08740735799074173, 0.051129646599292755, 0.0871722549200058, -0.034440405666828156, -0.030401434749364853, 0.0007986648706719279, -0.026736753061413765, -0.04473651573061943, -0.009893480688333511, -0.02292688749730587, -0.0760115459561348, 0.0054146344773471355, 0.023416437208652496, 0.026545660570263863, 0.0755447968840599, -0.021567946299910545, 0.01860411837697029, -0.011311809532344341, -0.0517793707549572, -0.05825371667742729, -0.08071981370449066, 0.020058689638972282, 0.1327217072248459, -0.06458195298910141, 0.01587819680571556, -0.015858149155974388, 0.05987360328435898, 0.07213576138019562, 0.0385381281375885, -0.014239856973290443, -0.05433002486824989, -0.07798844575881958, -0.02925698831677437, 0.012202552519738674, 0.07239449769258499, -0.03274363651871681, 0.0602114163339138, -0.046917617321014404, -0.10552452504634857, -0.04881786182522774, -0.007522912696003914, -0.046423330903053284, 0.01066150888800621, -0.009139684960246086, -0.07284271717071533, -0.08119890838861465, 0.06033968925476074, 0.01331767812371254, 0.011960683390498161, -0.050547175109386444, -0.04110005870461464, -0.03131069242954254, -0.05091824382543564, 0.05093366280198097, 0.04752688482403755, -0.014310838654637337, 0.02507716789841652, -0.009331402368843555, -0.04728396609425545, 0.03835555166006088, 0.04368455708026886, 0.06480788439512253, -0.028169943019747734, 0.026711320504546165, 0.04029345139861107, 0.09991924464702606, 0.14996470510959625, -4.3552052630957405e-8, 0.022092701867222786, -0.06311649084091187, -0.008023107424378395, 0.01759907603263855, 0.04540734365582466, -0.00913098081946373, 0.05977925285696983, 0.052624188363552094, -0.007764189038425684, -0.0471213161945343, 0.010298778302967548, 0.16314347088336945, -0.05838305130600929, 0.018983738496899605, 0.056117165833711624, 0.02731216698884964, -0.02568715251982212, 0.03132399916648865, -0.04275442287325859, -0.0021833651699125767, -0.057972632348537445, 0.056005727499723434, -0.07704732567071915, 0.028776705265045166, 0.006430592853575945, -0.04055285453796387, -0.017488684505224228, 0.02053324691951275, 0.021434489637613297, 0.02012702077627182, 0.06759253144264221, -0.05088493973016739, -0.04670819267630577, -0.05427747592329979, 0.03213484585285187, 0.08643102645874023, -0.0658208355307579, -0.04458314925432205, -0.006793539505451918, 0.08810249716043472, -0.035645078867673874, -0.0068128942511975765, -0.02348838746547699, 0.05161257088184357, 0.029178477823734283, -0.045955121517181396, -0.07956279814243317, 0.12217801064252853, 0.0058676861226558685, -0.0400339812040329, -0.03651037439703941, 0.08898510038852692, -0.0257203858345747, -0.06116010248661041, -0.0322258397936821, 0.013917827978730202, 0.02286340482532978, 0.004868331830948591, 0.03163187578320503, 0.01378703210502863, 0.04617271572351456, 0.04869139567017555, 0.08434019237756729, -0.03954549506306648 ]
molecules\tthat\tare\tjoined\ttogether,\tprimarily\tin\talpha\t1-4\tor\t1-6\tlinkages.\tMost\tof\tthe\tdietary\nstarches\tare\t\namylopectins\n,\tthe\tbranching\tpolysaccharides,\tand\tamylose,\tthe\tstraight\tchain–type\npolymers.\nDietary\tfiber\talso\tis\tmade\tlargely\tof\tchains\tand\tbranches\tof\tsugar\tmolecules,\tbut\tin\tthis\tcase\tthe
[ -0.013826897367835045, -0.07323267310857773, 0.04592633619904518, -0.04213876277208328, -0.0564844124019146, 0.03762345016002655, 0.0660448893904686, 0.025768138468265533, 0.022561389952898026, 0.08874797821044922, 0.09242145717144012, -0.03660258650779724, -0.011448442004621029, 0.0487089529633522, -0.011281982995569706, 0.016673175618052483, -0.04500814899802208, 0.02370513044297695, -0.013933878391981125, -0.011694386601448059, 0.06906730681657791, 0.07512728124856949, 0.0063606747426092625, -0.015932468697428703, 0.012455674819648266, 0.016181467100977898, -0.027083907276391983, 0.013749482110142708, 0.05319879204034805, -0.057838525623083115, -0.10907652974128723, 0.05204254388809204, -0.08552731573581696, 0.000712971726898104, 0.0752263218164444, 0.011596458964049816, -0.05150604248046875, 0.035751014947891235, 0.07630277425050735, 0.009506449103355408, 0.03942233324050903, -0.06874890625476837, -0.024596035480499268, 0.01681607961654663, 0.0382608138024807, 0.00418498320505023, 0.008532260544598103, -0.0024500959552824497, 0.0036375736817717552, -0.03866330906748772, -0.012036047875881195, 0.025423794984817505, -0.1139998659491539, 0.06602902710437775, 0.01674247719347477, 0.001434521866030991, -0.06405549496412277, -0.0384795144200325, -0.021178174763917923, -0.020546097308397293, 0.024495620280504227, -0.004429444670677185, -0.0363471694290638, -0.007896489463746548, 0.013010342605412006, 0.033228550106287, 0.05244112387299538, 0.0035160514526069164, 0.03109121322631836, 0.06283959001302719, -0.07385440170764923, -0.00276291579939425, -0.010779343545436859, 0.11333777010440826, -0.025089384987950325, 0.047479189932346344, 0.07544640451669693, 0.0053332531824707985, -0.014175739139318466, -0.053371645510196686, -0.10664156824350357, 0.07421644032001495, 0.057611413300037384, 0.08367133885622025, -0.03716164082288742, 0.02811449207365513, -0.007927794009447098, 0.07473579794168472, 0.001906571094878018, -0.0020517371594905853, 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hydrogens\tare\tpositioned\ton\tthe\tbeta\t(opposite)\tside\tof\tthe\toxygen\tin\tthe\tlink\tinstead\tof\tthe\talpha\nside.\tHumans\thave\tsignificant\tability\tto\tdigest\tstarch\tbut\tnot\tmost\tfiber;\tthis\texemplifies\tthe\n“stereospecificity”\tof\n\tenzymes.\nIn\tthe\tmouth,\tthe\tenzyme\tsalivary\tamylase\toperates\tat\ta\tneutral\tor\tslightly\talkaline\tpH\tand\tstarts
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the\tdigestive\taction\tby\thydrolyzing\ta\tsmall\tamount\tof\tthe\tstarch\tmolecules\tinto\tsmaller\tfragments\n(\nFig.\t1.6\n).\tAmylase\tdeactivates\tafter\tcontact\twith\thydrochloric\tacid.\tIf\tdigestible\tcarbohydrates\nremained\tin\tthe\tstomach\tlong\tenough,\tacid\thydrolysis\tcould\teventually\treduce\tmost\tof\tthem\tinto
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monosaccharides.\tHowever,\tthe\tstomach\tusually\tempties\tbefore\tsignificant\tdigestion\tcan\ttake\tplace.\nBy\tfar,\tmost\tcarbohydrate\tdigestion\toccurs\tin\tthe\tproximal\tsmall\tintestine.\nFIG.\t1.6\nThe\tgradual\tbreakdown\tof\tlarge\tstarch\tmolecules\tinto\tglucose\tby\tdigestion\tenzymes.
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0.03280017152428627, -0.025345370173454285, 0.07630595564842224, 0.11728107184171677, -4.5486633126756715e-8, 0.05369338020682335, -0.07582509517669678, -0.02000284567475319, -0.018530886620283127, 0.00226044119335711, -0.05487842112779617, 0.07180841267108917, 0.028640856966376305, 0.010942579247057438, -0.02006307803094387, 0.027344325557351112, 0.1416117399930954, -0.047381430864334106, -0.01845148392021656, -0.0018975596176460385, 0.026178983971476555, -0.07044006884098053, 0.048978645354509354, 0.008411421440541744, -0.049550559371709824, -0.0983075499534607, 0.061072345823049545, -0.044790301471948624, -0.0007342109456658363, 0.032911598682403564, -0.04008623957633972, 0.01827804371714592, 0.04491293057799339, 0.0490352101624012, 0.016085051000118256, 0.07498370856046677, 0.024130823090672493, 0.0030420105904340744, -0.05297449231147766, 0.03550826385617256, 0.05454987660050392, 0.002282560570165515, 0.01146830152720213, -0.056523099541664124, 0.07900699973106384, -0.015265054069459438, -0.0534658245742321, -0.031317755579948425, 0.039289090782403946, 0.03516063094139099, -0.06494203954935074, -0.008937196806073189, 0.13398031890392303, 0.012146255001425743, -0.03852776437997818, 0.0006852853111922741, 0.10830706357955933, -0.009806412272155285, -0.00473210820928216, -0.031458765268325806, -0.005800466053187847, 0.018401267006993294, 0.016424525529146194, 0.01563948765397072, -0.03601882606744766, 0.0690619945526123, 0.07664091140031815, 0.1204349622130394, -0.024226361885666847 ]
Pancreatic\tamylase\tbreaks\tthe\tlarge\tstarch\tmolecules\tat\tthe\t1-4\tlinkages\tto\tcreate\tmaltose,\nmaltotriose,\tand\t“alpha-limit”\tdextrins\tremaining\tfrom\tthe\tamylopectin\tbranches.\tEnzymes\tfrom\tthe\nbrush\tborder\tof\tthe\tenterocytes\tfurther\tbreak\tthe\tdisaccharides\tand\toligosaccharides\tinto\nmonosaccharides.\tFor\n\texample,\t\nmaltase
[ -0.028155837208032608, -0.10156948119401932, -0.0016763332532718778, -0.014500468969345093, -0.05038418993353844, 0.008808254264295101, 0.07669574022293091, 0.035367291420698166, -0.02007223293185234, 0.07858021557331085, 0.11298321932554245, -0.0067800297401845455, -0.027415620163083076, 0.03911101073026657, -0.06838488578796387, -0.013991257175803185, -0.06703303009271622, -0.006933859083801508, -0.040439799427986145, -0.010014208033680916, 0.09297214448451996, 0.0691056028008461, 0.05139380693435669, 0.024070734158158302, 0.06582710146903992, -0.03454222530126572, 0.02210928685963154, -0.04556673765182495, -0.052680160850286484, -0.09569983929395676, -0.09542857110500336, 0.03517216816544533, 0.03551196679472923, -0.017951903864741325, 0.07537166029214859, 0.02148253656923771, -0.02756829559803009, -0.010246233083307743, 0.05650202929973602, -0.044514451175928116, 0.06231383979320526, -0.10884983837604523, -0.032328493893146515, 0.035741016268730164, 0.02930409461259842, 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-0.019406935200095177, -0.082849882543087, -0.014179843477904797, -0.048015255481004715, 0.016210492700338364, -0.010739621706306934, 0.09475849568843842, -0.002303650137037039, 0.05596402660012245, -0.007093317806720734, -0.0007593943155370653, 0.013705411925911903, 0.04148072749376297, -0.15332888066768646, -0.0733206570148468, -0.03950168564915657, 0.035198718309402466, -0.07505736500024796, -0.02797245793044567, 0.036851540207862854, 0.015331371687352657, 0.05778465047478676, 0.005304873920977116, -0.01677633821964264, -0.007118419744074345, -0.053522687405347824, -0.0269857756793499, -0.015475164167582989, -0.08480421453714371, -0.05345611646771431, -0.03012259304523468, -0.08643892407417297, 0.0029184995219111443, 0.0004841633199248463, -0.059112872928380966, -0.004764803685247898, -0.0014501503901556134, -0.029827697202563286, 0.027674712240695953, -0.060188885778188705, -0.042367640882730484, -0.09041993319988251, -3.925950563022831e-33, 0.0260934941470623, -0.07040282338857651, -0.01109691895544529, 0.011021132580935955, -0.032869208604097366, 0.024385986849665642, 0.029863690957427025, -0.00668366951867938, 0.039051078259944916, -0.03251423314213753, 0.10289909690618515, 0.027373051270842552, -0.026810701936483383, -0.1360260248184204, -0.059526633471250534, 0.056731510907411575, -0.01166316494345665, 0.10644906759262085, -0.029276881366968155, -0.01947840303182602, -0.10084866732358932, 0.0932161882519722, -0.0672977864742279, 0.060090020298957825, 0.10331106185913086, 0.054654259234666824, 0.004182244651019573, 0.008316484279930592, 0.03784683719277382, 0.04441200941801071, 0.030344391241669655, -0.03729665279388428, -0.011805778369307518, -0.000722805445548147, 0.028203409165143967, -0.03284488618373871, -0.008030937053263187, -0.04528458043932915, -0.0011821947991847992, -0.008383814245462418, 0.005328987259417772, -0.0008812120649963617, 0.08328979462385178, 0.02085340954363346, 0.06419544667005539, 0.0005380461807362735, -0.10414715111255646, -0.034678615629673004, -0.029610300436615944, 0.04760080948472023, 0.04255477711558342, -0.046185556799173355, -0.029645845293998718, -0.019933458417654037, 0.02450941503047943, 0.04626128077507019, 0.06070354953408241, -0.058183569461107254, 0.021268872544169426, -0.06033677980303764, -0.05410067364573479, -0.018842650577425957, 0.040277741849422455, -0.008091222494840622, 0.059851713478565216, -0.06078968569636345, -0.10245489329099655, -0.02589707262814045, 0.009362946264445782, -0.010166428983211517, 0.0008788579725660384, 0.000419214426074177, -0.03031175583600998, -0.07620561867952347, 0.06708521395921707, -0.052688129246234894, -0.04776789993047714, -0.05133002623915672, -0.04241202399134636, -0.036567602306604385, -0.03118087537586689, -0.00283881020732224, 0.049348000437021255, -0.017299598082900047, 0.02924960106611252, -0.01623796485364437, -0.04644203558564186, 0.048637211322784424, -0.000459647155366838, 0.06979918479919434, -0.02282092534005642, 0.0216801930218935, -0.00943020824342966, 0.06427568942308426, 0.13563905656337738, -4.290886934654736e-8, 0.09190864115953445, -0.06026359274983406, 0.0021167839877307415, -0.030517905950546265, 0.05738108605146408, -0.011774172075092793, 0.0231179166585207, 0.051938656717538834, 0.020067326724529266, -0.066621333360672, -0.01925607956945896, 0.1601725071668625, -0.0775814950466156, 0.02231941930949688, 0.026011623442173004, 0.028910931199789047, -0.02233072929084301, 0.015818601474165916, -0.019940601661801338, -0.050894275307655334, -0.09588310122489929, 0.05663852393627167, -0.09574044495820999, 0.018389340490102768, -0.002276800572872162, -0.02039286121726036, 0.0012942318571731448, 0.05708225816488266, 0.008518146350979805, 0.026258962228894234, 0.09438957273960114, -0.022710507735610008, -0.02836950682103634, -0.06392272561788559, -0.0376458615064621, 0.04944640025496483, -0.017803093418478966, -0.0671854317188263, -0.03693665191531181, 0.07851642370223999, -0.025326624512672424, -0.044808901846408844, -0.03909914568066597, 0.022164655849337578, 0.009612209163606167, -0.048778317868709564, -0.00831221416592598, 0.10006838291883469, -0.00848882645368576, -0.04057653248310089, -0.0165494903922081, 0.0618291050195694, -0.05079148709774017, -0.012565845623612404, -0.04315676912665367, 0.003326183184981346, 0.10507897287607193, 0.0007846933440305293, 0.06499620527029037, -0.04489539936184883, 0.04994042590260506, 0.06978464871644974, 0.1625804603099823, -0.04968889057636261 ]
monosaccharides.\tFor\n\texample,\t\nmaltase\n\tlocated\tat\tthe\tenterocyte\tbrush\tborder\tmembrane\tbreaks\ndown\tthe\tdisaccharide\tmaltose\tinto\ttwo\tmolecules\tof\tglucose.\tThe\tbrush\tborder\tmembrane\talso\ncontains\tthe\tenzymes\t\nsucrase\n,\t\nlactase\n,\tand\t\nisomaltase\n,\twhich\tact\ton\tsucrose,\tlactose,\tand\nisomaltose,\trespectively\t(\nFig.\t1.7\n).
[ -0.02171507477760315, -0.11420749872922897, -0.025021638721227646, -0.009097251109778881, -0.0669981986284256, 0.02648206800222397, 0.05554095655679703, 0.044078852981328964, 0.009258348494768143, 0.07309603691101074, 0.07032542675733566, -0.011426596902310848, -0.0187070295214653, 0.031232064589858055, -0.03767244145274162, 0.0006231371662579477, -0.02788250707089901, -0.03388596326112747, -0.013166853226721287, -0.039567116647958755, 0.10544729232788086, 0.04261825233697891, 0.018364490941166878, 0.0014750331174582243, 0.07720395177602768, -0.019660508260130882, 0.015912678092718124, -0.0471217967569828, -0.04103359207510948, -0.05490864813327789, -0.09085649251937866, -0.011958683840930462, 0.04591743275523186, -0.014707141555845737, 0.08003725111484528, 0.04767347499728203, -0.024705084040760994, 0.01695883460342884, 0.03732747212052345, -0.0324435792863369, 0.024323957040905952, -0.0837845429778099, -0.0319746695458889, 0.016239246353507042, -0.01776689477264881, 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FIG.\t1.7\nStarch,\tsucrose,\tmaltotriose,\tand\tgalactose\tare\tdigested\tto\ttheir\tconstituent\tsugars.\tGlucose\tand\ngalactose\tare\ttransported\tthrough\tthe\tapical\tbrush\tborder\tmembrane\tof\tthe\tenterocyte\tby\ta\tsodium-\ndependent\ttransporter,\tglucose\t(galactose)\tcotransporter;\tfructose\tis\ttransported\tby\tglucose\ttransporter\t5
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(GLUT5).\tGlucose,\tfructose,\tand\tgalactose\tare\ttransported\tacross\tthe\tserosal\tmembrane\n\tby\tthe\tsodium-\nindependent\ttransporter,\tGLUT2.\nThe\tresultant\tmonosaccharides\t(i.e.,\tglucose,\tgalactose,\tand\tfructose)\tpass\tthrough\tthe\nenterocytes\tand\tinto\tthe\tbloodstream\tvia\tthe\tcapillaries\tof\tthe\tvilli,\twhere\tthey\tare\tcarried\tby\tthe
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portal\tvein\tto\tthe\tliver.\tAt\tlow\tconcentrations,\tglucose\tand\tgalactose\tare\tabsorbed\tby\tactive\ntransport,\tprimarily\tby\ta\tsodium-dependent\tactive\ttransporter\tcalled\n\tthe\tsodium-glucose\ncotransporter\t(SGLT1).\tAt\thigher\tluminal\tconcentrations\tof\tglucose,\tthe\tfacilitative\ttransporter
[ 0.01564391702413559, -0.09648938477039337, 0.030402936041355133, -0.00656344136223197, -0.05492120236158371, -0.010542807169258595, 0.0793297290802002, 0.03460061177611351, -0.006377516780048609, 0.04220306873321533, 0.07829398661851883, -0.019736578688025475, -0.020836299285292625, 0.05302537977695465, -0.005636004265397787, -0.039491526782512665, -0.008528405800461769, 0.0020869907457381487, -0.045916397124528885, -0.01415923796594143, 0.06902788579463959, 0.044369060546159744, 0.030868973582983017, -0.001327809994108975, 0.04675958305597305, 0.006945410743355751, -0.05702107772231102, 0.005651603918522596, 0.03762079030275345, -0.0827631875872612, -0.13798043131828308, 0.06355486065149307, -0.06957997381687164, 0.002404827391728759, 0.046365682035684586, 0.015799233689904213, -0.0764549970626831, -0.015939952805638313, -0.00019991848967038095, -0.012820383533835411, 0.019544197246432304, -0.10869903862476349, -0.0791461244225502, 0.02583574317395687, 0.028040766716003418, 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GLUT2\tbecomes\ta\tprimary\troute\tfor\ttransport\tof\tglucose\tfrom\tthe\tlumen\tinto\tthe\tenterocyte.\nFructose\tis\tabsorbed\tfrom\tthe\tintestinal\tlumen\tacross\tthe\tbrush\tborder\tmembrane\tusing\tthe\nfacilitative\ttransporter,\tGLUT5.\tAll\tthree\tmonosaccharides—glucose,\tgalactose,\tand\tfructose—exit
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the\tbasolateral\tmembrane\tof\tthe\tenterocyte\tinto\tportal\tcirculation\tusing\tthe\tfacilitative\ttransporter,\nGLUT2.\nThe\tactive\ttransporter,\tSGLT1,\tis\tkey\tto\tthe\tability\tof\tthe\tsmall\tintestine\tto\tabsorb\t7\tL\tof\tfluid\teach\nday\tand\tprovides\tthe\tbasis\tfor\twhy\toral\trehydration\tsolutions,\trather\tthan\twater\tor\tsugary\tdrinks,
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pathway\tfor\twater\tabsorption\tin\tthe\tsmall\tintestine,\tto\tfacilitate\twater\tabsorption,\tsodium\tand\nglucose\talso\tmust\tbe\tpresent\tin\tthe\tright\tamounts.\tThis\texplains\twhy\tthe\tmost\teffective\toral\nrehydration\tsolutions\n\toften\tinclude\tboth\tsugar\tand\tsalt,\tin\taddition\tto\twater.
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often\tinclude\tboth\tsugar\tand\tsalt,\tin\taddition\tto\twater.\nSome\tforms\tof\tcarbohydrates\t(i.e.,\tcellulose,\themicellulose,\tpectin,\tgum,\tand\tother\tforms\tof\tfiber)\ncannot\tbe\tdigested\tby\thumans\tbecause\tneither\tsalivary\tnor\tpancreatic\tamylase\thas\tthe\tability\tto
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split\tthe\tlinkages\tconnecting\tthe\tconstituent\tsugars.\tThese\tcarbohydrates\tpass\trelatively\tunchanged\ninto\tthe\tcolon,\twhere\tthey\tare\tpartially\tfermented\n\tby\tbacteria\tin\tthe\tcolon.\tHowever,\tunlike\thumans,\ncows\tand\tother\truminants\tcan\tsubsist\ton\thigh-fiber\tfood\tbecause\tof\tthe\tbacterial\tdigestion\tof\tthese
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carbohydrates\tthat\ttakes\tplace\tin\tthe\trumen.\tOther\tresistant\tstarches\tand\tsugars\tare\talso\tless\twell\ndigested\tor\tabsorbed\tby\thumans;\tthus\ttheir\tconsumption\tmay\tresult\tin\tsignificant\tamounts\tof\tstarch\nand\tsugar\tin\tthe\tcolon.\tThese\tresistant\tstarches\n\tand\tsome\ttypes\tof\tdietary\tfiber\tare\tfermented\tinto
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0.02583903819322586, -0.02852773293852806, 0.05015116184949875, 0.05261559784412384, -0.06383676081895828, -0.019221026450395584, 0.10118831694126129, -0.005454077385365963, -0.06213727220892906, -0.021173013374209404, 0.12243226170539856, -0.020686961710453033, -0.03374754637479782, -0.01533104944974184, -0.002868254669010639, 0.03346418961882591, 0.022578202188014984, -0.009382570162415504, 0.015908902511000633, 0.03735959157347679, 0.02245975099503994, 0.06506011635065079, -0.003984355833381414 ]
and\tsome\ttypes\tof\tdietary\tfiber\tare\tfermented\tinto\nSCFAs\tand\tgases.\tStarches\tresistant\tto\tdigestion\ttend\tto\tinclude\tplant\tfoods\twith\ta\thigh\tprotein\tand\nfiber\tcontent\tsuch\tas\tthose\tfrom\tlegumes\tand\twhole\tgrains.\nProteins\nProtein\tintake\tin\tthe\tWestern\tworld\tranges\tfrom\tapproximately\t50\tto\t100\tg\tdaily,\tand\ta\tgood\tdeal\tof
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the\tprotein\tconsumed\tis\tfrom\tanimal\tsources.\tAdditional\tprotein\tis\tadded\n\tall\talong\tthe\tGIT\tfrom\ngastrointestinal\tsecretions\tand\tsloughed\tepithelial\tcells.\tThe\tGIT\tis\tone\tof\tthe\tmost\tactive\tsynthetic\ntissues\tin\tthe\tbody,\tand\tthe\tlife\tspan\tof\tenterocytes\tmigrating\tfrom\tthe\tcrypts\tof\tthe\tvilli\tuntil\tthey
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are\tshed\tis\tonly\t3\tto\t5\tdays.\tThe\tnumber\tof\tcells\tshed\tdaily\tis\tin\tthe\trange\tof\t10\tto\t20\tbillion.\tThe\nlatter\taccounts\tfor\tan\tadditional\t50\tto\t60\tg\tof\tprotein\tthat\tis\tdigested\n\tand\t“recycled”\tand\tcontributes\nto\tthe\tdaily\tsupply.\tIn\tgeneral,\tanimal\tproteins\tare\tmore\tefficiently\tdigested\tthan\tplant\tproteins,\tbut
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is\tconverted\tinto\tthe\tenzyme\tpepsin\twhen\tit\ncontacts\thydrochloric\tacid\tand\tother\tpepsin\tmolecules.\tUnlike\tany\tof\tthe\tother\tproteolytic\tenzymes,\npepsin\tdigests\tcollagen,\tthe\tmajor\tprotein\tof\tconnective\ttissue.\tMost\tprotein\tdigestion\ttakes\tplace\tin\nthe\tupper\tportion\tof\tthe\tsmall\tintestine,\tbut\tit\tcontinues\tthroughout\tthe\tGIT.\tAny\tresidual\tprotein
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fractions\tare\tfermented\tby\tcolonic\tmicrobes.\nContact\n\tbetween\tchyme\tand\tthe\tintestinal\tmucosa\tallows\tfor\tthe\taction\tof\tthe\tbrush\tborder–bound\nenterokinase\n,\tan\tenzyme\tthat\ttransforms\tinactive\tpancreatic\t\ntrypsinogen\n\tinto\tactive\t\ntrypsin\n,\tthe\nmajor\tpancreatic\tprotein-digesting\tenzyme.\tTrypsin,\tin\tturn,\tactivates\tthe\tother\tpancreatic
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0.0013525522081181407, -0.041493579745292664, 0.04524332284927368, -0.07255770266056061, 0.005602071527391672, 0.02772516943514347, 0.013434558175504208, 0.03288032114505768, -0.0753130316734314, 0.08544029295444489, 0.07309706509113312, -0.041411392390728, -0.12421497702598572, -0.056153714656829834, 0.023352397605776787, -0.011346681043505669, 0.10139098763465881, -0.016922812908887863, 0.02359852008521557, -0.08590333163738251, 0.005349341779947281, -0.09381368011236191, 0.07710330933332443, 0.01741105318069458, 0.05926237255334854, 0.026759058237075806, 0.01005289051681757, 0.0616820827126503, 0.08067657053470612, 0.02438652329146862, -0.06638331711292267, -0.025132035836577415, 0.00485655665397644, -0.0021317952778190374, -0.029595106840133667, 0.01324438489973545, -0.03063444048166275, -0.061007775366306305, -0.017946450039744377, 0.026253290474414825, -0.021500470116734505, 0.09690263122320175, 0.006363419350236654, 0.03202922269701958, -0.025670086964964867, -0.07601601630449295, -0.049466803669929504, -0.09234992414712906, 0.034139182418584824, 0.07820101082324982, -0.02480573207139969, -0.031764257699251175, 0.013023014180362225, 0.04655338451266289, 0.044027313590049744, 0.019794965162873268, -0.07809184491634369, 0.0011333813890814781, -0.0016518853371962905, -0.017966413870453835, -0.010996431112289429, 0.058562036603689194, -0.03512044996023178, 0.05735406279563904, -0.03484161198139191, -0.05805441737174988, 0.005859585478901863, 0.017764002084732056, -0.051036302000284195, 0.033524610102176666, 0.013532685115933418, -0.04515024647116661, -0.0722033753991127, 0.06837208569049835, -0.03597332909703255, 0.028384294360876083, -0.04543508589267731, -0.014028585515916348, -0.04151662066578865, -0.030540939420461655, -0.016412856057286263, 0.01815299689769745, -0.013764343224465847, -0.029928673058748245, -0.0126566831022501, 0.0356542244553566, 0.043198250234127045, 0.06489840894937515, 0.03495773673057556, 0.011387608014047146, 0.031846340745687485, 0.0008373163873329759, 0.09229687601327896, 0.1508866846561432, -4.2905600849962866e-8, 0.06836088001728058, -0.03472575917840004, 0.017144573852419853, -0.034773021936416626, 0.036989398300647736, 0.009627919644117355, 0.03928906470537186, 0.024035833775997162, 0.004322177730500698, -0.06624770909547806, 0.0287482850253582, 0.11072339862585068, -0.08527986705303192, -0.0502840131521225, 0.09705571830272675, 0.022039368748664856, -0.013535666279494762, 0.07481413334608078, -0.05084313824772835, -0.07020287960767746, -0.06043599918484688, 0.07569630444049835, -0.017405837774276733, 0.003887900384142995, -0.007122524082660675, -0.0185660682618618, -0.058900136500597, 0.03580344468355179, 0.00913410633802414, 0.000998143688775599, 0.04234405606985092, -0.029497528448700905, -0.054535944014787674, -0.05456090718507767, -0.001844169688411057, 0.03619880974292755, -0.04227687418460846, -0.04721424728631973, -0.0031294268555939198, 0.11643367260694504, -0.005795993842184544, -0.06073257699608803, -0.03280860558152199, 0.038001127541065216, 0.004088677000254393, -0.07206909358501434, -0.04668977111577988, 0.06723984330892563, 0.007564110215753317, -0.04876899719238281, 0.007841989398002625, 0.11523563414812088, -0.017833810299634933, -0.037310849875211716, -0.06703884899616241, 0.010176881216466427, 0.05256493389606476, 0.0028207742143422365, -0.040571704506874084, -0.0032729387748986483, 0.0627681091427803, 0.06693030893802643, 0.10326667129993439, -0.05092630907893181 ]
proteolytic\tenzymes.\tPancreatic\ttrypsin,\tchymotrypsin,\tand\tcarboxypeptidase\tbreak\tdown\tintact\nprotein\tand\tcontinue\tthe\n\tbreakdown\tstarted\tin\tthe\tstomach\tuntil\tsmall\tpolypeptides\tand\tamino\tacids
[ -0.030383724719285965, -0.11320818960666656, -0.02918875589966774, -0.05219141021370888, -0.03770121559500694, 0.012248300947248936, 0.14611606299877167, 0.08596494793891907, 0.019415607675909996, 0.05825503170490265, 0.06957712769508362, -0.041870854794979095, -0.0004318345454521477, 0.07045058161020279, -0.04017554596066475, 0.0013157000066712499, -0.04388004168868065, 0.03626854717731476, -0.021998008713126183, -0.06128198280930519, 0.035346418619155884, 0.05598362907767296, -0.011687695048749447, 0.02301849238574505, -0.0066121406853199005, -0.011227691546082497, -0.004846462048590183, 0.003427924122661352, 0.005562479142099619, -0.06538882851600647, -0.12181456387042999, 0.03477708622813225, -0.01576106809079647, -0.018482383340597153, 0.08974146097898483, 0.020093552768230438, -0.06351710110902786, 0.019335193559527397, 0.02470380626618862, 0.013080845586955547, 0.05126079171895981, -0.04968562349677086, -0.06264089047908783, 0.001414966071024537, 0.030968759208917618, 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0.054145511239767075, -0.05941968038678169, -0.06361055374145508, -0.0008735916926525533, -0.0494329109787941, 0.048398520797491074, 0.010558671317994595, 0.09999680519104004, 0.01684555597603321, 0.06534726172685623, -0.02808755449950695, -0.0568091943860054, 0.0043366593308746815, 0.018284164369106293, -0.15274526178836823, -0.08371709287166595, -0.005602403078228235, 0.028171246871352196, -0.09530062228441238, 0.05515988543629646, 0.059810467064380646, 0.06775087118148804, 0.08667872101068497, 0.009225870482623577, 0.0003286470891907811, -0.03596140816807747, -0.04328983649611473, 0.000029487373467418365, -0.0472208596765995, -0.043721720576286316, -0.05603151023387909, -0.024480082094669342, -0.07689406722784042, 0.017164353281259537, 0.012939396314322948, -0.09373730421066284, -0.018045032396912575, -0.010821130126714706, -0.03560854494571686, 0.03057095967233181, -0.03912782669067383, -0.02293849177658558, -0.1384238600730896, -6.255504125180162e-33, -0.031196175143122673, -0.011047225445508957, -0.03267299383878708, -0.0071489629335701466, -0.03614095225930214, 0.03689154237508774, 0.002974672010168433, -0.007847483269870281, 0.04224036633968353, -0.03400612622499466, 0.0955585464835167, 0.004532120190560818, -0.020684588700532913, -0.10896416008472443, -0.07532579451799393, 0.04345110058784485, -0.012091917917132378, 0.0903758779168129, 0.008132655173540115, 0.00848916545510292, -0.08939224481582642, 0.033736295998096466, -0.07588811963796616, 0.04541638493537903, 0.08495376259088516, 0.057030610740184784, -0.008755449205636978, 0.007284337654709816, 0.0682368054986, 0.1082921028137207, 0.04528413340449333, 0.013212675228714943, -0.012648194096982479, 0.028601516038179398, -0.041784487664699554, -0.006472003646194935, 0.08145306259393692, -0.07236657291650772, -0.019497467204928398, -0.0052824802696704865, 0.026710394769906998, 0.015058809891343117, 0.09067675471305847, -0.013318696059286594, 0.04386159032583237, 0.05822832137346268, -0.1133100762963295, -0.033862173557281494, -0.05481316149234772, 0.019492652267217636, 0.06647288799285889, -0.035192668437957764, -0.02085583098232746, 0.0023649148643016815, 0.026476603001356125, 0.005509524140506983, 0.022028911858797073, -0.016578180715441704, -0.034297697246074677, -0.00799802877008915, 0.02175251953303814, -0.08633501827716827, 0.05684889853000641, 0.029963476583361626, 0.04635727405548096, -0.03149415925145149, -0.040822580456733704, 0.0028162156231701374, 0.03007054328918457, -0.05854945257306099, 0.04049959406256676, 0.007587401196360588, -0.03910081833600998, -0.09735952317714691, 0.012809026055037975, -0.03948991000652313, -0.00898030772805214, -0.056798141449689865, -0.006047650706022978, -0.04631885886192322, -0.028778282925486565, 0.01501353457570076, -0.004061042796820402, -0.02019714191555977, 0.00510838907212019, -0.013451208360493183, -0.002261885441839695, 0.06668077409267426, 0.06362481415271759, 0.03846548870205879, 0.0023189897183328867, 0.040138259530067444, 0.015736684203147888, 0.11234406381845474, 0.12464603781700134, -4.3600685728506505e-8, 0.08841221034526825, -0.03319742903113365, 0.03350187838077545, -0.04415220394730568, 0.07352729886770248, -0.015513322316110134, 0.006698261480778456, 0.03211583197116852, 0.01333226915448904, -0.08156786859035492, -0.01585465483367443, 0.08720942586660385, -0.08076499402523041, -0.059680622071027756, 0.08065736293792725, 0.06878181546926498, -0.021450450643897057, 0.06947030872106552, 0.00629186537116766, -0.05118296295404434, -0.02009938843548298, 0.05611526221036911, -0.05658880993723869, 0.04037324711680412, -0.001130257616750896, -0.058226898312568665, 0.015625080093741417, 0.0035086339339613914, -0.00044448109110817313, 0.029036788269877434, -0.0003914050757884979, -0.02886134758591652, -0.010433973744511604, -0.10687439143657684, 0.018911924213171005, 0.1327667087316513, -0.03814876079559326, -0.039840299636125565, -0.018712250515818596, 0.08571001142263412, -0.012715415097773075, -0.06110459938645363, -0.07688664644956589, -0.00004096531483810395, -0.003583566751331091, -0.06904017925262451, 0.006691147107630968, 0.07455851137638092, -0.017143484205007553, -0.09462149441242218, 0.02843373641371727, 0.07680465281009674, 0.0016927027609199286, -0.040910135954618454, -0.08321650326251984, 0.06306628882884979, 0.06084485724568367, -0.04198390245437622, -0.01625516265630722, -0.03727056831121445, -0.016520345583558083, 0.05829551815986633, 0.1322670429944992, -0.02230392023921013 ]
are\tformed.\nProteolytic\tpeptidases\tlocated\ton\tthe\tbrush\tborder\talso\tact\ton\tpolypeptides,\tbreaking\tthem\tdown\ninto\tamino\tacids,\tdipeptides,\tand\ttripeptides.\tThe\tfinal\tphase\tof\tprotein\tdigestion\ttakes\tplace\tin\tthe\nbrush\tborder,\twhere\tsome\tof\tthe\tdipeptides\tand\ttripeptides\tare\thydrolyzed\tinto\ttheir\tconstituent\namino\tacids\tby\n\tpeptide\thydrolases.
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amino\tacids\tby\n\tpeptide\thydrolases.\nEnd\tproducts\tof\tprotein\tdigestion\tare\tabsorbed\tas\tboth\tamino\tacids\tand\tsmall\tpeptides.\tSeveral\ntransport\tmolecules\tare\trequired\tfor\tthe\tdifferent\tamino\tacids,\tprobably\tbecause\tof\tthe\twide\ndifferences\tin\tthe\tsize,\tpolarity,\tand\tconfiguration\tof\tthe\tdifferent\tamino\tacids.\tSome\tof\tthe
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0.014117426238954067, 0.11668010801076889, 0.13348791003227234, -4.253218577332518e-8, 0.06910868734121323, -0.05744391679763794, -0.006171004846692085, -0.03640460595488548, 0.06177389621734619, -0.025250637903809547, 0.03220488503575325, 0.006680489517748356, 0.03341243043541908, -0.0930555909872055, 0.01612955890595913, 0.1308821141719818, -0.09444651752710342, -0.004249170888215303, 0.04259674251079559, 0.07178100198507309, -0.05760660022497177, 0.04019631817936897, -0.01772432215511799, -0.02479383535683155, -0.016292527318000793, 0.09593074023723602, -0.09821517765522003, 0.013090447522699833, 0.04396039620041847, -0.04130654036998749, -0.04964341223239899, 0.01165507361292839, 0.01688668504357338, 0.01061606127768755, 0.02653995342552662, -0.08654285967350006, 0.012483259662985802, -0.08215594291687012, 0.020634103566408157, 0.06574905663728714, -0.04682134464383125, -0.059505872428417206, -0.03098539635539055, 0.09546690434217453, -0.0024792668409645557, -0.023818202316761017, -0.07565166056156158, 0.04022479057312012, 0.0545620359480381, -0.04329521954059601, -0.06833042949438095, 0.13098420202732086, -0.01842157170176506, -0.05776958912611008, 0.0059947120025753975, 0.08588837087154388, -0.015732090920209885, -0.048690035939216614, -0.07124531269073486, 0.026899931952357292, 0.023048069328069687, -0.02747420035302639, 0.02164088748395443, -0.04364485666155815, 0.07355983555316925, 0.09300448000431061, 0.13494881987571716, -0.01674605906009674 ]
transporters\tare\tsodium\tor\tchloride\tdependent,\tand\tsome\tare\tnot.\tConsiderable\tamounts\tof\ndipeptides\n\tand\ttripeptides\talso\tare\tabsorbed\tinto\tintestinal\tcells\tusing\ta\tpeptide\ttransporter,\ta\tform\nof\tactive\ttransport\t(\nWuensch\tet\tal,\t2013\n).\tAbsorbed\tpeptides\tand\tamino\tacids\tare\ttransported\tto\tthe
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).\tAbsorbed\tpeptides\tand\tamino\tacids\tare\ttransported\tto\tthe\nliver\tvia\tthe\tportal\tvein\tfor\tmetabolism\tby\tthe\tliver\tand\tare\treleased\tinto\tthe\tgeneral\tcirculation.\nThe\tpresence\tof\tantibodies\tto\tmany\tfood\tproteins\tin\tthe\tcirculation\tof\thealthy\tindividuals\tindicates\nthat
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that\n\timmunologically\tsignificant\tamounts\tof\tlarge\tintact\tpeptides\tescape\thydrolysis\tand\tcan\tenter\nthe\tportal\tcirculation.\tThe\texact\tmechanisms\tthat\tcause\ta\tfood\tto\tbecome\tan\tallergen\tare\tnot\nentirely\tclear,\tbut\tthese\tfoods\ttend\tto\tbe\thigh\tin\tprotein,\tto\tbe\trelatively\tresistant\tto\tcomplete\ndigestion,\tand\tto\tproduce\tan\timmunoglobulin\tresponse\t(see
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digestion,\tand\tto\tproduce\tan\timmunoglobulin\tresponse\t(see\t\nChapter\t25\n).\tWith\tnew\ttechnology,\tit\tis\npossible\tto\tmap\n\tand\tcharacterize\tallergenic\tpeptides;\tthis\teventually\twill\tlead\tto\tbetter\tdiagnosis\tand\ndevelopment\tof\tsafe\timmunotherapy\ttreatments\t(\nMelioli\tet\tal,\t2014\n).
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development\tof\tsafe\timmunotherapy\ttreatments\t(\nMelioli\tet\tal,\t2014\n).\nAlmost\tall\tprotein\tis\tabsorbed\tby\tthe\ttime\tit\treaches\tthe\tend\tof\tthe\tjejunum,\tand\tonly\t1%\tof\ningested\tprotein\tis\tfound\tin\tthe\tfeces.\tSmall\tamounts\tof\tamino\tacids\tmay\tremain\tin\tthe\tepithelial\ncells\tand\tare\tused\tfor\tsynthesis\tof\tnew\tproteins,
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0.033043187111616135, -0.005223397631198168, 0.09817886352539062, 0.08510593324899673, -4.9346933650440405e-8, 0.012706531211733818, -0.005889229942113161, 0.016551939770579338, -0.01604115590453148, 0.040638267993927, -0.013274189084768295, 0.06589701026678085, 0.025540225207805634, 0.0023289485834538937, -0.06836223602294922, 0.02654566429555416, 0.07804370671510696, -0.06291874498128891, -0.00448686582967639, 0.100876085460186, 0.023256774991750717, -0.01467503234744072, 0.07710816711187363, -0.03342943266034126, -0.06361982971429825, -0.019529664888978004, 0.10268418490886688, 0.008193972520530224, -0.008794793859124184, -0.03909389674663544, -0.021573655307292938, -0.05446743592619896, -0.010764369741082191, -0.023295074701309204, -0.00009421481809113175, 0.08203431963920593, -0.019755203276872635, -0.012135058641433716, -0.06158274784684181, -0.023385489359498024, 0.04839214310050011, -0.024536550045013428, -0.05214821174740791, 0.010033175349235535, 0.16467401385307312, 0.011636513285338879, 0.01816726103425026, 0.001142960973083973, 0.07209359109401703, 0.04243406653404236, -0.04027284309267998, -0.031233686953783035, 0.08808476477861404, 0.005182762164622545, -0.11741390824317932, -0.008041533641517162, 0.08033722639083862, -0.019916530698537827, -0.07778558880090714, -0.052080295979976654, 0.04139142856001854, 0.08344046026468277, 0.026893623173236847, -0.009562056511640549, -0.002290681004524231, 0.05922539904713631, 0.0708991065621376, 0.10057563334703445, -0.00036821383400820196 ]
cells\tand\tare\tused\tfor\tsynthesis\tof\tnew\tproteins,\n\tincluding\tintestinal\tenzymes\tand\tnew\tcells.\nLipids\nApproximately\t97%\tof\tdietary\tlipids\tare\tin\tthe\tform\tof\ttriglycerides,\tand\tthe\trest\tare\tfound\tas\nphospholipids\tand\tcholesterol.\tOnly\tsmall\tamounts\tof\tfat\tare\tdigested\tin\tthe\tmouth\tby\tlingual\tlipase
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and\tin\tthe\tstomach\tfrom\tthe\taction\tof\tgastric\tlipase.\t\nGastric\tlipase\n\thydrolyzes\tsome\ttriglycerides,\nespecially\tshort-chain\ttriglycerides\t(such\tas\n\tthose\tfound\tin\tbutter),\tinto\tfatty\tacids\tand\tglycerol.\nHowever,\tmost\tfat\tdigestion\ttakes\tplace\tin\tthe\tsmall\tintestine\tas\ta\tresult\tof\tthe\temulsifying\taction\tof
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bile\tsalts\tand\thydrolysis\tby\tpancreatic\tlipase.\tAs\tin\tthe\tcase\tof\tcarbohydrates\tand\tprotein,\tthe\ncapacity\tfor\tdigestion\tand\tabsorption\tof\tdietary\tfat\tis\tin\texcess\tof\tordinary\tneeds.\nEntrance\tof\tfat\tand\tprotein\tinto\tthe\tsmall\tintestine\tstimulates\n\tthe\trelease\tof\tCCK,\tsecretin,\tand
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chenodeoxycholic\tacids\twith\tglycine\tor\ttaurine),\tbile\tpigments\t(which\tcolor\tthe\tfeces),\tinorganic\nsalts,\tsome\tprotein,\tcholesterol,\n\tlecithin,\tand\tmany\tcompounds\tsuch\tas\tdetoxified\tdrugs\tthat\tare\nmetabolized\tand\tsecreted\tby\tthe\tliver.\tFrom\tits\tstorage\torgan,\tthe\tgallbladder,\tapproximately\t1\tL\tof
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