instruction stringlengths 169 712 | input stringlengths 140 808 | response stringclasses 6
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<Instruct>: Given the context 'I kappa B-epsilon would, therefore, appear to regulate a late, transient activation of a subset of genes, regulated by RelA/cRel NF-kappa B complexes, distinct from those regulated by other I kappa B proteins.', select the correct biomedical concept corresponding to 'nf-kappa b'. Answer u... | <Options>: A: nuclear factor kappa b subunit 1 (homo sapiens) (aka nuclear factor kappa b subunit 1)
B: relb proto-oncogene, nf-kb subunit (homo sapiens) (aka relb proto-oncogene, nf-kb subunit)
C: nf-kb2 (homo sapiens) (aka nuclear factor kappa b subunit 2)
D: nfkbib (homo sapiens) (aka nfkb inhibitor beta)
E: rela pr... | A |
<Instruct>: Given the context 'Characterization of VPS41, a gene required for vacuolar trafficking and high-affinity iron transport in yeast.
', select the correct biomedical concept corresponding to 'vps41'. Answer using one of the provided options. | <Options>: A: transmembrane protein 41 homolog (caenorhabditis elegans) (aka transmembrane protein 41 homolog)
B: vps41 (saccharomyces cerevisiae s288c) (aka vps41p)
C: vacuolar protein sorting-associated protein 41 homolog (caenorhabditis elegans) (aka vacuolar protein sorting-associated protein 41 homolog)
D: vps41 (... | B |
<Instruct>: Given the context 'Mutations in the yeast gene VPS41 give rise to poor growth on low iron medium, severe alterations in vacuolar morphology, and cause the missorting of membranous and soluble vacuolar proteins.', select the correct biomedical concept corresponding to 'vps41'. Answer using one of the provide... | <Options>: A: vps41 (saccharomyces cerevisiae s288c) (aka vps41p)
B: transmembrane protein 41 homolog (caenorhabditis elegans) (aka transmembrane protein 41 homolog)
C: vps41 (homo sapiens) (aka vps41 subunit of hops complex)
D: vps41 (drosophila melanogaster) (aka light)
E: vacuolar protein sorting-associated protein ... | A |
<Instruct>: Given the context 'Our studies predict that VPS41 encodes a hydrophilic protein of 992 amino acids that contains no obvious signal sequence or hydrophobic domains.', select the correct biomedical concept corresponding to 'vps41'. Answer using one of the provided options. | <Options>: A: vacuolar protein sorting-associated protein 41 homolog (caenorhabditis elegans) (aka vacuolar protein sorting-associated protein 41 homolog)
B: transmembrane protein 41 homolog (caenorhabditis elegans) (aka transmembrane protein 41 homolog)
C: vps41 (drosophila melanogaster) (aka light)
D: hvps41 (homo sa... | E |
<Instruct>: Given the context 'The deduced Vps41p sequence contains a domain rich in glutamic and aspartic residues, as well as a domain with resemblance to a region of clathrin heavy chain.', select the correct biomedical concept corresponding to 'vps41p'. Answer using one of the provided options. | <Options>: A: vps41 (drosophila melanogaster) (aka light)
B: vps41p (saccharomyces cerevisiae s288c) (aka vps41p)
C: atg41p (saccharomyces cerevisiae s288c) (aka atg41p)
D: vomeronasal 1 receptor 41 pseudogene (homo sapiens) (aka vomeronasal 1 receptor 41 pseudogene)
E: vps41p (candida albicans sc5314) (aka vps41p)
F: ... | B |
<Instruct>: Given the context 'The VPS41 homologues (but not the yeast VPS41 itself) contain a conserved cysteine-rich RING-H2 zinc finger at their COOH termini.', select the correct biomedical concept corresponding to 'vps41'. Answer using one of the provided options. | <Options>: A: vacuolar protein sorting-associated protein 41 homolog (caenorhabditis elegans) (aka vacuolar protein sorting-associated protein 41 homolog)
B: vps41p (saccharomyces cerevisiae s288c) (aka vps41p)
C: hvps41p (homo sapiens) (aka vps41 subunit of hops complex)
D: vps41 (drosophila melanogaster) (aka light)
... | B |
<Instruct>: Given the context 'The VPS41 homologues (but not the yeast VPS41 itself) contain a conserved cysteine-rich RING-H2 zinc finger at their COOH termini.', select the correct biomedical concept corresponding to 'vps41'. Answer using one of the provided options. | <Options>: A: transmembrane protein 41 homolog (caenorhabditis elegans) (aka transmembrane protein 41 homolog)
B: vps41 (drosophila melanogaster) (aka light)
C: hvps41p (homo sapiens) (aka vps41 subunit of hops complex)
D: vacuolar protein sorting-associated protein 41 homolog (caenorhabditis elegans) (aka vacuolar pro... | E |
<Instruct>: Given the context 'Biochemical experiments suggest that VPS41 functions in post-Golgi protein processing: the deletion mutant exhibits defective high affinity transport due to impaired Fet3p activity and also exhibits defects in the processing and sorting of multiple vacuolar hydrolases.', select the correc... | <Options>: A: vacuolar protein sorting-associated protein 41 homolog (caenorhabditis elegans) (aka vacuolar protein sorting-associated protein 41 homolog)
B: vps41 (homo sapiens) (aka vps41 subunit of hops complex)
C: vps41 (saccharomyces cerevisiae s288c) (aka vps41p)
D: vps41 (drosophila melanogaster) (aka light)
E: ... | C |
<Instruct>: Given the context 'Biochemical experiments suggest that VPS41 functions in post-Golgi protein processing: the deletion mutant exhibits defective high affinity transport due to impaired Fet3p activity and also exhibits defects in the processing and sorting of multiple vacuolar hydrolases.', select the correc... | <Options>: A: fer3-like bhlh transcription factor (xenopus tropicalis) (aka fer3-like bhlh transcription factor)
B: fet3 (saccharomyces cerevisiae s288c) (aka ferroxidase fet3)
C: etf1p3 (homo sapiens) (aka eukaryotic translation termination factor 1 pseudogene 3)
D: fer3 (drosophila melanogaster) (ferritin 3 heavy cha... | B |
<Instruct>: Given the context 'Biochemical experiments suggest that VPS41 functions in post-Golgi protein processing: the deletion mutant exhibits defective high affinity transport due to impaired Fet3p activity and also exhibits defects in the processing and sorting of multiple vacuolar hydrolases.', select the correc... | <Options>: A: fet4p (saccharomyces cerevisiae s288c) (aka fet4p)
B: fthl3p (homo sapiens) (aka ferritin heavy chain 1 pseudogene 3)
C: ferry endosomal rab5 effector complex subunit 3 (xenopus tropicalis) (aka ferry endosomal rab5 effector complex subunit 3)
D: transcription factor 3 pseudogene 1 (homo sapiens) (aka tra... | F |
<Instruct>: Given the context 'Isolation of a full-length human WNT7A gene implicated in limb development and cell transformation, and mapping to chromosome 3p25.
', select the correct biomedical concept corresponding to 'wnt7a'. Answer using one of the provided options. | <Options>: A: wnt7a (homo sapiens) (aka wnt family member 7a)
B: wnt family member 7a (gallus gallus) (aka wnt family member 7a)
C: wnt family member 7b (homo sapiens) (aka wnt family member 7b)
D: wnt7c-a (xenopus laevis) (wingless-type mmtv integration site family, member 7c s homeolog (xenopus laevis)) (aka wingless... | A |
<Instruct>: Given the context 'One mouse member, Wnt7a, is vital for limb development in vivo and also possesses transforming ability in vitro.', select the correct biomedical concept corresponding to 'wnt7a'. Answer using one of the provided options. | <Options>: A: wnt-7a (xenopus laevis) (wingless-type mmtv integration site family member 7a s homeolog (xenopus laevis)) (aka wingless-type mmtv integration site family member 7a s homeolog)
B: wnt7a (homo sapiens) (aka wnt family member 7a)
C: wnt family member 7b (homo sapiens) (aka wnt family member 7b)
D: wnt7c-a (... | B |
<Instruct>: Given the context 'This study reports the isolation of a full length of human homologue of mouse Wnt7a gene by library screening.', select the correct biomedical concept corresponding to 'wnt7a'. Answer using one of the provided options. | <Options>: A: wnt family member 7a (gallus gallus) (aka wnt family member 7a)
B: wnt family member 7a (xenopus tropicalis) (aka wnt family member 7a)
C: wnt7c-a (xenopus laevis) (wingless-type mmtv integration site family, member 7c s homeolog (xenopus laevis)) (aka wingless-type mmtv integration site family, member 7c... | E |
<Instruct>: Given the context 'Yeast artificial chromosome-fluorescence in situ hybridisation (YAC-FISH) mapped the WNT7A gene to chromosome 3p25.', select the correct biomedical concept corresponding to 'wnt7a'. Answer using one of the provided options. | <Options>: A: wnt-7a (xenopus laevis) (wingless-type mmtv integration site family member 7a s homeolog (xenopus laevis)) (aka wingless-type mmtv integration site family member 7a s homeolog)
B: wnt7a (gallus gallus) (aka wnt family member 7a)
C: wnt7c-a (xenopus laevis) (wingless-type mmtv integration site family, memb... | E |
<Instruct>: Given the context 'Human WNT7A had an ORF encoding a deduced protein of 349 aa that exhibited 97% and 92% identity to mouse Wnt7a at the aa and nucleic acid levels, respectively.', select the correct biomedical concept corresponding to 'wnt7a'. Answer using one of the provided options. | <Options>: A: wnt7a (gallus gallus) (aka wnt family member 7a)
B: wnt7c-a (xenopus laevis) (wingless-type mmtv integration site family, member 7c s homeolog (xenopus laevis)) (aka wingless-type mmtv integration site family, member 7c s homeolog)
C: wnt family member 7a (homo sapiens) (aka wnt family member 7a)
D: wnt-7... | C |
<Instruct>: Given the context 'Human WNT7A had an ORF encoding a deduced protein of 349 aa that exhibited 97% and 92% identity to mouse Wnt7a at the aa and nucleic acid levels, respectively.', select the correct biomedical concept corresponding to 'wnt7a'. Answer using one of the provided options. | <Options>: A: wnt family member 7a (homo sapiens) (aka wnt family member 7a)
B: wnt7a (gallus gallus) (aka wnt family member 7a)
C: wnt-7a (xenopus laevis) (wingless-type mmtv integration site family member 7a s homeolog (xenopus laevis)) (aka wingless-type mmtv integration site family member 7a s homeolog)
D: wnt7c-a ... | A |
<Instruct>: Given the context 'The MAD-related protein Smad7 associates with the TGFbeta receptor and functions as an antagonist of TGFbeta signaling.
', select the correct biomedical concept corresponding to 'smad7'. Answer using one of the provided options. | <Options>: A: smad7 (homo sapiens) (aka smad family member 7)
B: smad6 (homo sapiens) (aka smad family member 6)
C: smad family member 5 (mus musculus) (aka smad family member 5)
D: smad family member 6 (mus musculus) (aka smad family member 6)
E: smad7 (drosophila melanogaster) (aka daughters against dpp)
F: None of t... | A |
<Instruct>: Given the context 'TGFbeta signaling is initiated when the type I receptor phosphorylates the MAD-related protein, Smad2, on C-terminal serine residues.', select the correct biomedical concept corresponding to 'smad2'. Answer using one of the provided options. | <Options>: A: smad-2 (mus musculus) (aka smad family member 2)
B: smad2/3 (drosophila melanogaster) (aka smad on x)
C: madh2 (homo sapiens) (aka smad family member 2)
D: None of the above. | C |
<Instruct>: Given the context 'This leads to Smad2 association with Smad4, translocation to the nucleus, and regulation of transcriptional responses.', select the correct biomedical concept corresponding to 'smad2'. Answer using one of the provided options. | <Options>: A: smad family member 2 (mus musculus) (aka smad family member 2)
B: smad2/3 (drosophila melanogaster) (aka smad on x)
C: smad2 (homo sapiens) (aka smad family member 2)
D: None of the above. | C |
<Instruct>: Given the context 'This leads to Smad2 association with Smad4, translocation to the nucleus, and regulation of transcriptional responses.', select the correct biomedical concept corresponding to 'smad4'. Answer using one of the provided options. | <Options>: A: smad4 (homo sapiens) (aka smad family member 4)
B: smad4 (drosophila melanogaster) (aka medea)
C: smad family member 4 (xenopus tropicalis) (aka smad family member 4)
D: mad4 (homo sapiens) (aka max dimerization protein 4)
E: smad family member 4 (mus musculus) (aka smad family member 4)
F: None of the ab... | A |
<Instruct>: Given the context 'This leads to Smad2 association with Smad4, translocation to the nucleus, and regulation of transcriptional responses.', select the correct biomedical concept corresponding to 'smad4'. Answer using one of the provided options. | <Options>: A: smad4 (mus musculus) (aka smad family member 4)
B: smad4 (drosophila melanogaster) (aka medea)
C: smad family member 5 (homo sapiens) (aka smad family member 5)
D: mad4 (homo sapiens) (aka max dimerization protein 4)
E: smad family member 4 (xenopus tropicalis) (aka smad family member 4)
F: None of the ab... | F |
<Instruct>: Given the context 'Here we demonstrate that Smad7 is an inhibitor of TGFbeta signaling.', select the correct biomedical concept corresponding to 'smad7'. Answer using one of the provided options. | <Options>: A: smad family member 6 (mus musculus) (aka smad family member 6)
B: smad (drosophila melanogaster) (mothers against dpp (drosophila melanogaster)) (aka mothers against dpp)
C: smad family member 6 (homo sapiens) (aka smad family member 6)
D: smad7 (homo sapiens) (aka smad family member 7)
E: smad family mem... | D |
<Instruct>: Given the context 'Smad7 prevents TGFbeta-dependent formation of Smad2/Smad4 complexes and inhibits the nuclear accumulation of Smad2.', select the correct biomedical concept corresponding to 'smad7'. Answer using one of the provided options. | <Options>: A: smad7 (mus musculus) (aka smad family member 7)
B: smad family member 5 (mus musculus) (aka smad family member 5)
C: smad6 (homo sapiens) (aka smad family member 6)
D: smad7 (homo sapiens) (aka smad family member 7)
E: smad (drosophila melanogaster) (mothers against dpp (drosophila melanogaster)) (aka mot... | D |
<Instruct>: Given the context 'Smad7 prevents TGFbeta-dependent formation of Smad2/Smad4 complexes and inhibits the nuclear accumulation of Smad2.', select the correct biomedical concept corresponding to 'smad2'. Answer using one of the provided options. | <Options>: A: smad2/3 (drosophila melanogaster) (aka smad on x)
B: smad family member 2 (mus musculus) (aka smad family member 2)
C: smad2 (homo sapiens) (aka smad family member 2)
D: None of the above. | C |
<Instruct>: Given the context 'Smad7 prevents TGFbeta-dependent formation of Smad2/Smad4 complexes and inhibits the nuclear accumulation of Smad2.', select the correct biomedical concept corresponding to 'smad4'. Answer using one of the provided options. | <Options>: A: smad family member 4 (mus musculus) (aka smad family member 4)
B: smad family member 4 (homo sapiens) (aka smad family member 4)
C: smad family member 4 (xenopus tropicalis) (aka smad family member 4)
D: smad4 (drosophila melanogaster) (aka medea)
E: smad family member 5 (homo sapiens) (aka smad family me... | B |
<Instruct>: Given the context 'Smad7 prevents TGFbeta-dependent formation of Smad2/Smad4 complexes and inhibits the nuclear accumulation of Smad2.', select the correct biomedical concept corresponding to 'smad2'. Answer using one of the provided options. | <Options>: A: smad2 (drosophila melanogaster) (aka smad on x)
B: smad family member 2 (homo sapiens) (aka smad family member 2)
C: smad-2 (mus musculus) (aka smad family member 2)
D: None of the above. | B |
<Instruct>: Given the context 'Smad7 interacts stably with the activated TGFbeta type I receptor, thereby blocking the association, phosphorylation, and activation of Smad2.', select the correct biomedical concept corresponding to 'smad7'. Answer using one of the provided options. | <Options>: A: smad7 (drosophila melanogaster) (aka daughters against dpp)
B: smad family member 6 (mus musculus) (aka smad family member 6)
C: smad7 (mus musculus) (aka smad family member 7)
D: smad family member 7 (homo sapiens) (aka smad family member 7)
E: smad family member 5 (mus musculus) (aka smad family member ... | D |
<Instruct>: Given the context 'Smad7 interacts stably with the activated TGFbeta type I receptor, thereby blocking the association, phosphorylation, and activation of Smad2.', select the correct biomedical concept corresponding to 'tgfbeta type i receptor'. Answer using one of the provided options. | <Options>: A: transforming growth factor beta receptor 1 (bos taurus) (aka transforming growth factor beta receptor 1)
B: tbetar-i (homo sapiens) (aka transforming growth factor beta receptor 1)
C: transforming growth factor, beta receptor i (mus musculus) (aka transforming growth factor, beta receptor i)
D: transformi... | B |
<Instruct>: Given the context 'Smad7 interacts stably with the activated TGFbeta type I receptor, thereby blocking the association, phosphorylation, and activation of Smad2.', select the correct biomedical concept corresponding to 'smad2'. Answer using one of the provided options. | <Options>: A: smad2 (homo sapiens) (aka smad family member 2)
B: smad family member 2 (mus musculus) (aka smad family member 2)
C: smad2/3 (drosophila melanogaster) (aka smad on x)
D: None of the above. | A |
<Instruct>: Given the context 'Furthermore, mutations in Smad7 that interfere with receptor binding disrupt its inhibitory activity.', select the correct biomedical concept corresponding to 'smad7'. Answer using one of the provided options. | <Options>: A: smad family member 7 (mus musculus) (aka smad family member 7)
B: smad7 (drosophila melanogaster) (aka daughters against dpp)
C: smad6 (homo sapiens) (aka smad family member 6)
D: smad family member 7 (homo sapiens) (aka smad family member 7)
E: smad (drosophila melanogaster) (mothers against dpp (drosoph... | D |
<Instruct>: Given the context 'SOX22 is a new member of the SOX gene family, mainly expressed in human nervous tissue.
', select the correct biomedical concept corresponding to 'sox22'. Answer using one of the provided options. | <Options>: A: sox22 (homo sapiens) (aka sry-box transcription factor 12)
B: sox25 (homo sapiens) (aka sry-box transcription factor 21)
C: transcription factor sox-2-like (homo sapiens) (aka transcription factor sox-2-like)
D: sox2 (homo sapiens) (aka sry-box transcription factor 2)
E: sox2.s (xenopus laevis) (sry-box 2... | A |
<Instruct>: Given the context 'SOX22 is a new member of the SOX gene family, mainly expressed in human nervous tissue.
', select the correct biomedical concept corresponding to 'sox22'. Answer using one of the provided options. | <Options>: A: sox2 (homo sapiens) (aka sry-box transcription factor 2)
B: sox27 (homo sapiens) (aka sry-box transcription factor 15)
C: sox21 (homo sapiens) (aka sry-box transcription factor 21)
D: transcription factor sox-2-like (homo sapiens) (aka transcription factor sox-2-like)
E: sox28 (homo sapiens) (aka sry-box ... | F |
<Instruct>: Given the context 'SOX (SRY box-containing) genes share a particular DNA-binding domain, called HMG, with the mammalian testis-determining gene SRY Several SOX genes have already been shown to be transcription factors involved in the decision of important cell fates during development.', select the correct ... | <Options>: A: sry (drosophila melanogaster) (sprouty (drosophila melanogaster)) (aka sprouty)
B: sry-box transcription factor 1 (homo sapiens) (aka sry-box transcription factor 1)
C: sex-determining region y protein (sus scrofa) (aka sex-determining region y protein)
D: sry promoter region (homo sapiens) (aka sry promo... | E |
<Instruct>: Given the context 'Here we report the cloning of a new human member of the SOX gene family, SOX22.', select the correct biomedical concept corresponding to 'sox22'. Answer using one of the provided options. | <Options>: A: sox22 (homo sapiens) (aka sry-box transcription factor 12)
B: sox2.s (xenopus laevis) (sry-box 2 s homeolog (xenopus laevis)) (aka sry-box 2 s homeolog)
C: sox2 (homo sapiens) (aka sry-box transcription factor 2)
D: sox27 (homo sapiens) (aka sry-box transcription factor 15)
E: sox25 (homo sapiens) (aka sr... | A |
<Instruct>: Given the context 'The SOX22 gene maps to chromosome 20 on band p13 and does not appear to be clustered with any other SOX gene mapped to date.', select the correct biomedical concept corresponding to 'sox22'. Answer using one of the provided options. | <Options>: A: sox28 (homo sapiens) (aka sry-box transcription factor 14)
B: sox27 (homo sapiens) (aka sry-box transcription factor 15)
C: sox21 (homo sapiens) (aka sry-box transcription factor 21)
D: sox22 (homo sapiens) (aka sry-box transcription factor 12)
E: sox2.s (xenopus laevis) (sry-box 2 s homeolog (xenopus lae... | D |
<Instruct>: Given the context 'SOX22 mRNA is expressed in various fetal and adult organs and tissues, suggesting that this gene plays roles in both differentiation and maintenance of several cell types.', select the correct biomedical concept corresponding to 'sox22'. Answer using one of the provided options. | <Options>: A: sox2.s (xenopus laevis) (sry-box 2 s homeolog (xenopus laevis)) (aka sry-box 2 s homeolog)
B: transcription factor sox-2-like (homo sapiens) (aka transcription factor sox-2-like)
C: sox22 (homo sapiens) (aka sry-box transcription factor 12)
D: sox28 (homo sapiens) (aka sry-box transcription factor 14)
E: ... | C |
<Instruct>: Given the context 'A novel human serine-threonine phosphatase related to the Drosophila retinal degeneration C (rdgC) gene is selectively expressed in sensory neurons of neural crest origin.
', select the correct biomedical concept corresponding to 'retinal degeneration c'. Answer using one of the provided ... | <Options>: A: retinal degeneration a (drosophila melanogaster) (aka retinal degeneration a)
B: retinal degeneration g (drosophila melanogaster) (aka retinal degeneration g)
C: retinal degeneration c (drosophila melanogaster) (aka retinal degeneration c)
D: retinal degeneration e (drosophila melanogaster) (aka retinal d... | C |
<Instruct>: Given the context 'A novel human serine-threonine phosphatase related to the Drosophila retinal degeneration C (rdgC) gene is selectively expressed in sensory neurons of neural crest origin.
', select the correct biomedical concept corresponding to 'rdgc'. Answer using one of the provided options. | <Options>: A: rdgc (escherichia coli str. k-12 substr. mg1655) (aka nucleoid-associated protein rdgc)
B: retinal degeneration g (drosophila melanogaster) (aka retinal degeneration g)
C: rdgb1 (homo sapiens) (aka phosphatidylinositol transfer protein membrane associated 1)
D: rdgc (drosophila melanogaster) (aka retinal ... | D |
<Instruct>: Given the context 'Through our transcriptional mapping effort in the Xp22 region, we have isolated by exon trapping a new transcript highly homologous to the Drosophila retinal degeneration C (rdgC) gene.', select the correct biomedical concept corresponding to 'retinal degeneration c'. Answer using one of ... | <Options>: A: retinal degeneration h (drosophila melanogaster) (aka retinal degeneration h)
B: retinal degeneration d (drosophila melanogaster) (aka retinal degeneration d)
C: retinal degeneration c (drosophila melanogaster) (aka retinal degeneration c)
D: primary retinal dysplasia (homo sapiens) (aka primary retinal d... | C |
<Instruct>: Given the context 'Through our transcriptional mapping effort in the Xp22 region, we have isolated by exon trapping a new transcript highly homologous to the Drosophila retinal degeneration C (rdgC) gene.', select the correct biomedical concept corresponding to 'rdgc'. Answer using one of the provided optio... | <Options>: A: rdgc (drosophila melanogaster) (aka retinal degeneration c)
B: retgc (homo sapiens) (aka guanylate cyclase 2d, retinal)
C: rdgca (homo sapiens) (aka integral membrane protein 2b)
D: retinal degeneration g (drosophila melanogaster) (aka retinal degeneration g)
E: retinal pigment epithelium-derived rhodopsi... | A |
<Instruct>: Given the context 'rdgC encodes a serine/threonine phosphatase protein and is required in Drosophila to prevent light-induced retinal degeneration.', select the correct biomedical concept corresponding to 'rdgc'. Answer using one of the provided options. | <Options>: A: rdgca (homo sapiens) (aka integral membrane protein 2b)
B: rdgb (homo sapiens) (aka phosphatidylinositol transfer protein membrane associated 1)
C: rd3 (homo sapiens) (aka rd3 regulator of gucy2d)
D: retinal pigment epithelium-derived rhodopsin homolog (xenopus tropicalis) (aka retinal pigment epithelium-... | E |
<Instruct>: Given the context 'This human gene is the first mammalian member of the serine-threonine phosphatase with EF hand motif gene family, and was thus named PPEF (Protein Phosphatase with EF calcium-binding domain).', select the correct biomedical concept corresponding to 'ppef'. Answer using one of the provided... | <Options>: A: ppef1 (bos taurus) (aka protein phosphatase with ef-hand domain 1)
B: ppef-1 (mus musculus) (aka protein phosphatase with ef hand calcium-binding domain 1)
C: ppef2 (xenopus tropicalis) (aka protein phosphatase, ef-hand calcium binding domain 2)
D: pedf (homo sapiens) (aka serpin family f member 1)
E: ppe... | E |
<Instruct>: Given the context 'This human gene is the first mammalian member of the serine-threonine phosphatase with EF hand motif gene family, and was thus named PPEF (Protein Phosphatase with EF calcium-binding domain).', select the correct biomedical concept corresponding to 'ppef'. Answer using one of the provided... | <Options>: A: ppef2 (homo sapiens) (aka protein phosphatase with ef-hand domain 2)
B: epf (homo sapiens) (aka heat shock protein family e (hsp10) member 1)
C: ppef2 (xenopus tropicalis) (aka protein phosphatase, ef-hand calcium binding domain 2)
D: ppef1 (bos taurus) (aka protein phosphatase with ef-hand domain 1)
E: p... | F |
<Instruct>: Given the context 'The expression pattern of the mouse Ppef gene was studied by RNA in situ hybridization on embryonic tissue sections.', select the correct biomedical concept corresponding to 'ppef'. Answer using one of the provided options. | <Options>: A: ppef1 (bos taurus) (aka protein phosphatase with ef-hand domain 1)
B: ppef1 (mus musculus) (aka protein phosphatase with ef hand calcium-binding domain 1)
C: epf (homo sapiens) (aka heat shock protein family e (hsp10) member 1)
D: ppef1 (xenopus tropicalis) (aka protein phosphatase, ef-hand calcium bindin... | B |
<Instruct>: Given the context 'While rdgC is expressed in the visual system of the fly, as well as in the mushroom bodies of the central brain, we found that Ppef is highly expressed in sensory neurons of the dorsal root ganglia (DRG) and neural crest-derived cranial ganglia.', select the correct biomedical concept cor... | <Options>: A: retgc (homo sapiens) (aka guanylate cyclase 2d, retinal)
B: rdgc (escherichia coli str. k-12 substr. mg1655) (aka nucleoid-associated protein rdgc)
C: retinal pigment epithelium-derived rhodopsin homolog (xenopus tropicalis) (aka retinal pigment epithelium-derived rhodopsin homolog)
D: rdgb (homo sapiens)... | E |
<Instruct>: Given the context 'While rdgC is expressed in the visual system of the fly, as well as in the mushroom bodies of the central brain, we found that Ppef is highly expressed in sensory neurons of the dorsal root ganglia (DRG) and neural crest-derived cranial ganglia.', select the correct biomedical concept cor... | <Options>: A: ppef2 (xenopus tropicalis) (aka protein phosphatase, ef-hand calcium binding domain 2)
B: ppef1 (bos taurus) (aka protein phosphatase with ef-hand domain 1)
C: pedf (homo sapiens) (aka serpin family f member 1)
D: ppef1 (mus musculus) (aka protein phosphatase with ef hand calcium-binding domain 1)
E: ppef... | D |
<Instruct>: Given the context 'The selective pattern of expression makes PPEF an important marker for sensory neuron differentiation and suggests a role for serine-threonine phosphatases in mammalian development.', select the correct biomedical concept corresponding to 'ppef'. Answer using one of the provided options. | <Options>: A: ppef1 (homo sapiens) (aka protein phosphatase with ef-hand domain 1)
B: ppef2 (homo sapiens) (aka protein phosphatase with ef-hand domain 2)
C: ppef-1 (mus musculus) (aka protein phosphatase with ef hand calcium-binding domain 1)
D: ppef1 (bos taurus) (aka protein phosphatase with ef-hand domain 1)
E: ped... | A |
<Instruct>: Given the context 'Cloning and characterization of hOGG1, a human homolog of the OGG1 gene of Saccharomyces cerevisiae.
', select the correct biomedical concept corresponding to 'hogg1'. Answer using one of the provided options. | <Options>: A: 8-oxoguanine dna glycosylase (homo sapiens) (aka 8-oxoguanine dna glycosylase)
B: homg1 (homo sapiens) (aka transient receptor potential cation channel subfamily m member 6)
C: hoga1 (homo sapiens) (aka 4-hydroxy-2-oxoglutarate aldolase 1)
D: hgh1 (homo sapiens) (aka hgh1 cochaperone)
E: hhg1 (homo sapien... | A |
<Instruct>: Given the context 'Cloning and characterization of hOGG1, a human homolog of the OGG1 gene of Saccharomyces cerevisiae.
', select the correct biomedical concept corresponding to 'ogg1'. Answer using one of the provided options. | <Options>: A: ogg1 (drosophila melanogaster) (aka 8-oxoguanine dna glycosylase)
B: ogg1 (mus musculus) (aka 8-oxoguanine dna-glycosylase 1)
C: ogs1 (homo sapiens) (aka midline 1)
D: ogg1 (oryctolagus cuniculus) (aka 8-oxoguanine dna glycosylase)
E: ogh1 (homo sapiens) (aka 8-oxoguanine dna glycosylase)
F: None of the a... | F |
<Instruct>: Given the context 'The OGG1 gene of Saccharomyces cerevisiae encodes a DNA glycosylase activity that is a functional analog of the Fpg protein from Escherichia coli and excises 7,8-dihydro-8-oxoguanine (8-oxoG) from damaged DNA.', select the correct biomedical concept corresponding to 'ogg1'. Answer using o... | <Options>: A: ogg1 (drosophila melanogaster) (aka 8-oxoguanine dna glycosylase)
B: ogs1 (homo sapiens) (aka midline 1)
C: ogg1 (mus musculus) (aka 8-oxoguanine dna-glycosylase 1)
D: n-glycosylase/dna lyase ogg1 (glycine max) (aka n-glycosylase/dna lyase ogg1)
E: hogg1 (homo sapiens) (aka 8-oxoguanine dna glycosylase)
F... | F |
<Instruct>: Given the context 'The OGG1 gene of Saccharomyces cerevisiae encodes a DNA glycosylase activity that is a functional analog of the Fpg protein from Escherichia coli and excises 7,8-dihydro-8-oxoguanine (8-oxoG) from damaged DNA.', select the correct biomedical concept corresponding to 'fpg'. Answer using on... | <Options>: A: fpgs (homo sapiens) (aka folylpolyglutamate synthase)
B: fpgt (xenopus tropicalis) (aka fucose-1-phosphate guanylyltransferase)
C: fpg (escherichia coli str. k-12 substr. mg1655) (aka dna-formamidopyrimidine glycosylase)
D: fpgt (xenopus laevis) (aka fucose-1-phosphate guanylyltransferase l homeolog)
E: f... | C |
<Instruct>: Given the context 'This protein shares a 38% sequence identity with the yeast Ogg1 protein, adding this novel human gene product to the growing family of enzymes that the repair of oxidatively damaged bases and are related to the E. coli endonuclease III.', select the correct biomedical concept correspondin... | <Options>: A: 8-oxoguanine dna glycosylase (oryctolagus cuniculus) (aka 8-oxoguanine dna glycosylase)
B: ogs1 (homo sapiens) (aka midline 1)
C: hogg1 (homo sapiens) (aka 8-oxoguanine dna glycosylase)
D: ogg1 (mus musculus) (aka 8-oxoguanine dna-glycosylase 1)
E: n-glycosylase/dna lyase ogg1 (glycine max) (aka n-glycosy... | F |
<Instruct>: Given the context 'This protein shares a 38% sequence identity with the yeast Ogg1 protein, adding this novel human gene product to the growing family of enzymes that the repair of oxidatively damaged bases and are related to the E. coli endonuclease III.', select the correct biomedical concept correspondin... | <Options>: A: dna-(apurinic or apyrimidinic site) endonuclease;exodeoxyribonuclease iii (caenorhabditis elegans) (aka dna-(apurinic or apyrimidinic site) endonuclease;exodeoxyribonuclease iii)
B: endonuclease v (xenopus tropicalis) (aka endonuclease v)
C: endonuclease v (rattus norvegicus) (aka endonuclease v)
D: endon... | E |
<Instruct>: Given the context 'This protein shares a 38% sequence identity with the yeast Ogg1 protein, adding this novel human gene product to the growing family of enzymes that the repair of oxidatively damaged bases and are related to the E. coli endonuclease III.', select the correct biomedical concept correspondin... | <Options>: A: cn-iii (homo sapiens) (aka 5'-nucleotidase, cytosolic iiia)
B: endo-i (drosophila melanogaster) (uncharacterized protein (drosophila melanogaster)) (aka uncharacterized protein)
C: endonuclease v (xenopus tropicalis) (aka endonuclease v)
D: endonuclease v (homo sapiens) (aka endonuclease v)
E: endonucleas... | F |
<Instruct>: Given the context 'The cloned coding sequence was expressed in an E. coli strain that carried a disrupted fpg gene, the bacterial functional analog of OGG1.', select the correct biomedical concept corresponding to 'fpg'. Answer using one of the provided options. | <Options>: A: fpg (escherichia coli str. k-12 substr. mg1655) (aka dna-formamidopyrimidine glycosylase)
B: fpg-1 (arabidopsis thaliana) (aka mutm homolog-1)
C: fpgt (homo sapiens) (aka fucose-1-phosphate guanylyltransferase)
D: fpgt (xenopus tropicalis) (aka fucose-1-phosphate guanylyltransferase)
E: fpg1 (homo sapiens... | A |
<Instruct>: Given the context 'The cloned coding sequence was expressed in an E. coli strain that carried a disrupted fpg gene, the bacterial functional analog of OGG1.', select the correct biomedical concept corresponding to 'ogg1'. Answer using one of the provided options. | <Options>: A: ogg1 (mus musculus) (aka 8-oxoguanine dna-glycosylase 1)
B: ogs1 (homo sapiens) (aka midline 1)
C: n-glycosylase/dna lyase ogg1 (glycine max) (aka n-glycosylase/dna lyase ogg1)
D: ogg1 (drosophila melanogaster) (aka 8-oxoguanine dna glycosylase)
E: hogg1 (homo sapiens) (aka 8-oxoguanine dna glycosylase)
F... | F |
<Instruct>: Given the context 'The products of the reaction are consistent with an enzymatic activity like the one displayed by the yeast Ogg1.', select the correct biomedical concept corresponding to 'ogg1'. Answer using one of the provided options. | <Options>: A: ogg1 (mus musculus) (aka 8-oxoguanine dna-glycosylase 1)
B: ogg1 (drosophila melanogaster) (aka 8-oxoguanine dna glycosylase)
C: ogg1 (oryctolagus cuniculus) (aka 8-oxoguanine dna glycosylase)
D: ogs1 (homo sapiens) (aka midline 1)
E: n-glycosylase/dna lyase ogg1 (glycine max) (aka n-glycosylase/dna lyase... | F |
<Instruct>: Given the context 'Moreover, when the human coding sequence was expressed in a yeast strain mutant in OGG1 it was able to complement the spontaneous mutator phenotype.', select the correct biomedical concept corresponding to 'ogg1'. Answer using one of the provided options. | <Options>: A: ogg1 (mus musculus) (aka 8-oxoguanine dna-glycosylase 1)
B: ogs1 (homo sapiens) (aka midline 1)
C: ogg1 (oryctolagus cuniculus) (aka 8-oxoguanine dna glycosylase)
D: n-glycosylase/dna lyase ogg1 (glycine max) (aka n-glycosylase/dna lyase ogg1)
E: 8-oxoguanine dna glycosylase (homo sapiens) (aka 8-oxoguani... | F |
<Instruct>: Given the context 'These results make this novel gene (hOGG1) a strong candidate for the human homolog of the yeast OGG1 and suggest an important role of its product in the protection of the genome from the mutagenic effects of the oxidatively damaged purines.', select the correct biomedical concept corresp... | <Options>: A: homg1 (homo sapiens) (aka transient receptor potential cation channel subfamily m member 6)
B: ogg1 (homo sapiens) (aka 8-oxoguanine dna glycosylase)
C: hoga1 (homo sapiens) (aka 4-hydroxy-2-oxoglutarate aldolase 1)
D: hgh1 (homo sapiens) (aka hgh1 cochaperone)
E: hspg1 (homo sapiens) (aka syndecan 2)
F: ... | B |
<Instruct>: Given the context 'These results make this novel gene (hOGG1) a strong candidate for the human homolog of the yeast OGG1 and suggest an important role of its product in the protection of the genome from the mutagenic effects of the oxidatively damaged purines.', select the correct biomedical concept corresp... | <Options>: A: ogg1 (mus musculus) (aka 8-oxoguanine dna-glycosylase 1)
B: ogg1 (oryctolagus cuniculus) (aka 8-oxoguanine dna glycosylase)
C: n-glycosylase/dna lyase ogg1 (glycine max) (aka n-glycosylase/dna lyase ogg1)
D: ogs1 (homo sapiens) (aka midline 1)
E: ogg1 (homo sapiens) (aka 8-oxoguanine dna glycosylase)
F: N... | F |
<Instruct>: Given the context 'A minK-HERG complex regulates the cardiac potassium current I(Kr).
MinK is a widely expressed protein of relative molecular mass approximately 15K that forms potassium channels by aggregation with other membrane proteins.', select the correct biomedical concept corresponding to 'mink'. An... | <Options>: A: mink1 (mus musculus) (aka misshapen-like kinase 1 (zebrafish))
B: mink (homo sapiens) (potassium voltage-gated channel subfamily e regulatory subunit 1 (homo sapiens)) (aka potassium voltage-gated channel subfamily e regulatory subunit 1)
C: mink (homo sapiens) (misshapen like kinase 1 (homo sapiens)) (ak... | B |
<Instruct>: Given the context 'A minK-HERG complex regulates the cardiac potassium current I(Kr).
MinK is a widely expressed protein of relative molecular mass approximately 15K that forms potassium channels by aggregation with other membrane proteins.', select the correct biomedical concept corresponding to 'herg'. An... | <Options>: A: kcng (homo sapiens) (aka potassium voltage-gated channel modifier subfamily g member 1)
B: herg-2 (homo sapiens) (aka potassium voltage-gated channel subfamily h member 6)
C: h-eag (homo sapiens) (aka potassium voltage-gated channel subfamily h member 1)
D: kcnrg (homo sapiens) (aka potassium channel regu... | E |
<Instruct>: Given the context 'A minK-HERG complex regulates the cardiac potassium current I(Kr).
MinK is a widely expressed protein of relative molecular mass approximately 15K that forms potassium channels by aggregation with other membrane proteins.', select the correct biomedical concept corresponding to 'mink'. An... | <Options>: A: mink (mus musculus) (potassium voltage-gated channel, isk-related subfamily, member 1 (mus musculus)) (aka potassium voltage-gated channel, isk-related subfamily, member 1)
B: mink1 (homo sapiens) (aka misshapen like kinase 1)
C: mink (homo sapiens) (potassium voltage-gated channel subfamily e regulatory ... | C |
<Instruct>: Given the context 'MinK governs ion channel activation, regulation by second messengers, and the function and structure of the ion conduction pathway.', select the correct biomedical concept corresponding to 'mink'. Answer using one of the provided options. | <Options>: A: min (mus musculus) (aka apc, wnt signaling pathway regulator)
B: mink (drosophila melanogaster) (aka mitotic spindle and nuclear protein)
C: minp (homo sapiens) (aka bmerb domain containing 1)
D: mink (mus musculus) (potassium voltage-gated channel, isk-related subfamily, member 1 (mus musculus)) (aka pot... | E |
<Instruct>: Given the context 'MinK governs ion channel activation, regulation by second messengers, and the function and structure of the ion conduction pathway.', select the correct biomedical concept corresponding to 'mink'. Answer using one of the provided options. | <Options>: A: mink1 (mus musculus) (aka misshapen-like kinase 1 (zebrafish))
B: mina (mus musculus) (aka ribosomal oxygenase 2)
C: min (mus musculus) (aka apc, wnt signaling pathway regulator)
D: minp (homo sapiens) (aka bmerb domain containing 1)
E: min1 (homo sapiens) (aka cd59 molecule (cd59 blood group))
F: None of... | F |
<Instruct>: Given the context 'Association of minK with a channel protein known as KvLQT1 produces a voltage-gated outward K+ current (I[sK]) resembling the slow cardiac repolarization current (I[Ks]).', select the correct biomedical concept corresponding to 'mink'. Answer using one of the provided options. | <Options>: A: mink (homo sapiens) (potassium voltage-gated channel subfamily e regulatory subunit 1 (homo sapiens)) (aka potassium voltage-gated channel subfamily e regulatory subunit 1)
B: mink1 (mus musculus) (aka misshapen-like kinase 1 (zebrafish))
C: mink1 (homo sapiens) (aka misshapen like kinase 1)
D: min1 (homo... | A |
<Instruct>: Given the context 'Association of minK with a channel protein known as KvLQT1 produces a voltage-gated outward K+ current (I[sK]) resembling the slow cardiac repolarization current (I[Ks]).', select the correct biomedical concept corresponding to 'kvlqt1'. Answer using one of the provided options. | <Options>: A: kvlqt1 (rattus norvegicus) (aka potassium voltage-gated channel subfamily q member 1)
B: kvlqt1 (homo sapiens) (aka potassium voltage-gated channel subfamily q member 1)
C: kvlqt1 (sus scrofa) (aka potassium voltage-gated channel subfamily q member 1)
D: kvlqt1 (mus musculus) (aka potassium voltage-gated ... | B |
<Instruct>: Given the context 'HERG, a human homologue of the ether-a-go-go gene of the fruitfly Drosophila melanogaster, encodes a protein that produces the rapidly activating cardiac delayed rectifier (I[Kr]).', select the correct biomedical concept corresponding to 'herg'. Answer using one of the provided options. | <Options>: A: herg (homo sapiens) (aka potassium voltage-gated channel subfamily h member 2)
B: kcnrg (homo sapiens) (aka potassium channel regulator)
C: h-eag (homo sapiens) (aka potassium voltage-gated channel subfamily h member 1)
D: herg-2 (homo sapiens) (aka potassium voltage-gated channel subfamily h member 6)
E:... | A |
<Instruct>: Given the context 'HERG, a human homologue of the ether-a-go-go gene of the fruitfly Drosophila melanogaster, encodes a protein that produces the rapidly activating cardiac delayed rectifier (I[Kr]).', select the correct biomedical concept corresponding to 'ether-a-go-go'. Answer using one of the provided o... | <Options>: A: go-alpha (drosophila melanogaster) (aka g protein alpha subunit o)
B: gok (homo sapiens) (aka stromal interaction molecule 1)
C: ether a go-go (drosophila melanogaster) (aka ether a go-go)
D: goe (drosophila melanogaster) (aka gone early)
E: go (drosophila melanogaster) (gold tip (drosophila melanogaster)... | C |
<Instruct>: Given the context 'Although heterologously expressed HERG channels are largely indistinguishable from native cardiac I(Kr), a role for minK in this current is suggested by the diminished I(Kr) in an atrial tumour line subjected to minK antisense suppression.', select the correct biomedical concept correspon... | <Options>: A: girk1 (homo sapiens) (aka potassium inwardly rectifying channel subfamily j member 3)
B: kcnrg (homo sapiens) (aka potassium channel regulator)
C: herg (homo sapiens) (aka potassium voltage-gated channel subfamily h member 2)
D: herg3 (homo sapiens) (aka potassium voltage-gated channel subfamily h member ... | C |
<Instruct>: Given the context 'Although heterologously expressed HERG channels are largely indistinguishable from native cardiac I(Kr), a role for minK in this current is suggested by the diminished I(Kr) in an atrial tumour line subjected to minK antisense suppression.', select the correct biomedical concept correspon... | <Options>: A: mina (mus musculus) (aka ribosomal oxygenase 2)
B: min1 (homo sapiens) (aka cd59 molecule (cd59 blood group))
C: mink1 (homo sapiens) (aka misshapen like kinase 1)
D: mink (homo sapiens) (potassium voltage-gated channel subfamily e regulatory subunit 1 (homo sapiens)) (aka potassium voltage-gated channel ... | D |
<Instruct>: Given the context 'Although heterologously expressed HERG channels are largely indistinguishable from native cardiac I(Kr), a role for minK in this current is suggested by the diminished I(Kr) in an atrial tumour line subjected to minK antisense suppression.', select the correct biomedical concept correspon... | <Options>: A: mink (mus musculus) (potassium voltage-gated channel, isk-related subfamily, member 1 (mus musculus)) (aka potassium voltage-gated channel, isk-related subfamily, member 1)
B: min (mus musculus) (aka apc, wnt signaling pathway regulator)
C: mink (homo sapiens) (potassium voltage-gated channel subfamily e ... | C |
<Instruct>: Given the context 'Here we show that HERG and minK form a stable complex, and that this heteromultimerization regulates I(Kr) activity.', select the correct biomedical concept corresponding to 'herg'. Answer using one of the provided options. | <Options>: A: eag1 (homo sapiens) (aka potassium voltage-gated channel subfamily h member 1)
B: girk1 (homo sapiens) (aka potassium inwardly rectifying channel subfamily j member 3)
C: kcng (homo sapiens) (aka potassium voltage-gated channel modifier subfamily g member 1)
D: herg-2 (homo sapiens) (aka potassium voltage... | E |
<Instruct>: Given the context 'Here we show that HERG and minK form a stable complex, and that this heteromultimerization regulates I(Kr) activity.', select the correct biomedical concept corresponding to 'mink'. Answer using one of the provided options. | <Options>: A: mink (homo sapiens) (potassium voltage-gated channel subfamily e regulatory subunit 1 (homo sapiens)) (aka potassium voltage-gated channel subfamily e regulatory subunit 1)
B: mink1 (homo sapiens) (aka misshapen like kinase 1)
C: mink (drosophila melanogaster) (aka mitotic spindle and nuclear protein)
D: ... | A |
<Instruct>: Given the context 'MinK, through the formation of heteromeric channel complexes, is thus central to the control of the heart rate and rhythm.', select the correct biomedical concept corresponding to 'mink'. Answer using one of the provided options. | <Options>: A: mink (drosophila melanogaster) (aka mitotic spindle and nuclear protein)
B: mink (mus musculus) (potassium voltage-gated channel, isk-related subfamily, member 1 (mus musculus)) (aka potassium voltage-gated channel, isk-related subfamily, member 1)
C: mink1 (homo sapiens) (aka misshapen like kinase 1)
D: ... | E |
<Instruct>: Given the context 'MinK, through the formation of heteromeric channel complexes, is thus central to the control of the heart rate and rhythm.', select the correct biomedical concept corresponding to 'mink'. Answer using one of the provided options. | <Options>: A: mink1 (mus musculus) (aka misshapen-like kinase 1 (zebrafish))
B: min (mus musculus) (aka apc, wnt signaling pathway regulator)
C: mink (mus musculus) (potassium voltage-gated channel, isk-related subfamily, member 1 (mus musculus)) (aka potassium voltage-gated channel, isk-related subfamily, member 1)
D:... | F |
<Instruct>: Given the context 'X-linked IAP is a direct inhibitor of cell-death proteases.
', select the correct biomedical concept corresponding to 'x-linked iap'. Answer using one of the provided options. | <Options>: A: ml-iap (xenopus laevis) (baculoviral iap repeat containing 7 s homeolog (xenopus laevis)) (aka baculoviral iap repeat containing 7 s homeolog)
B: c-iap1 (homo sapiens) (aka baculoviral iap repeat containing 2)
C: x-linked inhibitor of apoptosis (homo sapiens) (aka x-linked inhibitor of apoptosis)
D: c-iap... | C |
<Instruct>: Given the context 'Here we show that human X-chromosome-linked IAP directly inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7.', select the correct biomedical concept corresponding to 'x-chromosome-linked iap'. Answer using one of the provided options. | <Options>: A: xxiap (xenopus laevis) (x-linked inhibitor of apoptosis s homeolog (xenopus laevis)) (aka x-linked inhibitor of apoptosis s homeolog)
B: ml-iap (xenopus laevis) (baculoviral iap repeat containing 7 l homeolog (xenopus laevis)) (aka baculoviral iap repeat containing 7 l homeolog)
C: x-linked inhibitor of a... | C |
<Instruct>: Given the context 'Here we show that human X-chromosome-linked IAP directly inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7.', select the correct biomedical concept corresponding to 'caspase-3'. Answer using one of the provided options. | <Options>: A: casp3 (homo sapiens) (aka caspase 3)
B: casp-3 (mus musculus) (aka caspase 3)
C: ich-3 (homo sapiens) (aka caspase 5)
D: caspase-3 (xenopus tropicalis) (aka caspase 3, gene 2)
E: caspase-3 (drosophila melanogaster) (aka death executioner caspase related to apopain/yama)
F: None of the above. | A |
<Instruct>: Given the context 'Here we show that human X-chromosome-linked IAP directly inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7.', select the correct biomedical concept corresponding to 'caspase-7'. Answer using one of the provided options. | <Options>: A: casp7 (homo sapiens) (aka caspase 7)
B: casp5 (homo sapiens) (aka caspase 5)
C: casp8 (homo sapiens) (aka caspase 8)
D: caspase-7 (mus musculus) (aka caspase 7)
E: casp3 (homo sapiens) (aka caspase 3)
F: None of the above. | A |
<Instruct>: Given the context 'Differential expression of FMR1, FXR1 and FXR2 proteins in human brain and testis.
', select the correct biomedical concept corresponding to 'fmr1'. Answer using one of the provided options. | <Options>: A: fmr1 (drosophila melanogaster) (aka fragile x messenger ribonucleoprotein 1)
B: fxr1-a (xenopus laevis) (fmr1 autosomal homolog 1 s homeolog (xenopus laevis)) (aka fmr1 autosomal homolog 1 s homeolog)
C: fmr1 autosomal homolog 1 (mus musculus) (aka fmr1 autosomal homolog 1)
D: fmr1 autosomal homolog 1 (xe... | F |
<Instruct>: Given the context 'Differential expression of FMR1, FXR1 and FXR2 proteins in human brain and testis.
', select the correct biomedical concept corresponding to 'fxr1'. Answer using one of the provided options. | <Options>: A: fxr (xenopus tropicalis) (aka nuclear receptor subfamily 1 group h member 4)
B: fxr1 (homo sapiens) (aka fmr1 autosomal homolog 1)
C: fxr1-a (xenopus laevis) (fmr1 autosomal homolog 1 l homeolog (xenopus laevis)) (aka fmr1 autosomal homolog 1 l homeolog)
D: fxr (homo sapiens) (aka nuclear receptor subfami... | B |
<Instruct>: Given the context 'Differential expression of FMR1, FXR1 and FXR2 proteins in human brain and testis.
', select the correct biomedical concept corresponding to 'fxr2'. Answer using one of the provided options. | <Options>: A: nr1f2 (homo sapiens) (aka rar related orphan receptor b)
B: fxrb (homo sapiens) (aka nuclear receptor subfamily 1 group h member 5, pseudogene)
C: fmr1 autosomal homolog 2 (homo sapiens) (aka fmr1 autosomal homolog 2)
D: fxr (homo sapiens) (aka nuclear receptor subfamily 1 group h member 4)
E: fxr1-b (xen... | C |
<Instruct>: Given the context 'Lack of expression of the fragile X mental retardation protein (FMRP) results in mental retardation and macroorchidism, seen as the major pathological symptoms in fragile X patients.', select the correct biomedical concept corresponding to 'fragile x mental retardation protein'. Answer us... | <Options>: A: fmr1 autosomal homolog 1 (homo sapiens) (aka fmr1 autosomal homolog 1)
B: fmr1as (homo sapiens) (aka fmr1 antisense rna 1)
C: fragile x messenger ribonucleoprotein 1 (homo sapiens) (aka fragile x messenger ribonucleoprotein 1)
D: fraxf (homo sapiens) (aka transmembrane protein 185a)
E: fxr (drosophila mel... | C |
<Instruct>: Given the context 'Lack of expression of the fragile X mental retardation protein (FMRP) results in mental retardation and macroorchidism, seen as the major pathological symptoms in fragile X patients.', select the correct biomedical concept corresponding to 'fmrp'. Answer using one of the provided options. | <Options>: A: fmrp (xenopus tropicalis) (aka fragile x messenger ribonucleoprotein 1)
B: fmr1 autosomal homolog 1 (homo sapiens) (aka fmr1 autosomal homolog 1)
C: fmr1 autosomal homolog 1 (mus musculus) (aka fmr1 autosomal homolog 1)
D: fragile x messenger ribonucleoprotein 1 (drosophila melanogaster) (aka fragile x me... | E |
<Instruct>: Given the context 'FMRP is a cytoplasmic RNA-binding protein which cosediments with the 60S ribosomal subunit.', select the correct biomedical concept corresponding to 'fmrp'. Answer using one of the provided options. | <Options>: A: fxr (drosophila melanogaster) (fragile x messenger ribonucleoprotein 1 (drosophila melanogaster)) (aka fragile x messenger ribonucleoprotein 1)
B: fmrp (xenopus tropicalis) (aka fragile x messenger ribonucleoprotein 1)
C: fmr1 autosomal homolog 1 (mus musculus) (aka fmr1 autosomal homolog 1)
D: fmr1 autos... | E |
<Instruct>: Given the context 'FMRP is a cytoplasmic RNA-binding protein which cosediments with the 60S ribosomal subunit.', select the correct biomedical concept corresponding to 'fmrp'. Answer using one of the provided options. | <Options>: A: fmr1 autosomal homolog 1 (xenopus tropicalis) (frx1l (xenopus tropicalis)) (aka fmr1 autosomal homolog 1)
B: fmrp (mus musculus) (aka fragile x messenger ribonucleoprotein 1)
C: fmr1 autosomal homolog 1 (mus musculus) (aka fmr1 autosomal homolog 1)
D: fmr1 autosomal homolog 1 (homo sapiens) (aka fmr1 auto... | F |
<Instruct>: Given the context 'Recently, two proteins homologous to FMRP were discovered: FXR1 and FXR2.', select the correct biomedical concept corresponding to 'fmrp'. Answer using one of the provided options. | <Options>: A: fmr1 autosomal homolog 1 (homo sapiens) (aka fmr1 autosomal homolog 1)
B: fmrp (mus musculus) (aka fragile x messenger ribonucleoprotein 1)
C: fmrp (xenopus tropicalis) (aka fragile x messenger ribonucleoprotein 1)
D: fmrp (drosophila melanogaster) (aka fragile x messenger ribonucleoprotein 1)
E: fmrp (ho... | E |
<Instruct>: Given the context 'Recently, two proteins homologous to FMRP were discovered: FXR1 and FXR2.', select the correct biomedical concept corresponding to 'fxr1'. Answer using one of the provided options. | <Options>: A: fxr (homo sapiens) (aka nuclear receptor subfamily 1 group h member 4)
B: fxr1 (homo sapiens) (aka fmr1 autosomal homolog 1)
C: fxr (xenopus tropicalis) (aka nuclear receptor subfamily 1 group h member 4)
D: fxr1-b (xenopus laevis) (fmr1 autosomal homolog 1 s homeolog (xenopus laevis)) (aka fmr1 autosomal... | B |
<Instruct>: Given the context 'Recently, two proteins homologous to FMRP were discovered: FXR1 and FXR2.', select the correct biomedical concept corresponding to 'fxr2'. Answer using one of the provided options. | <Options>: A: fxr1-b (xenopus tropicalis) (aka fmr1 autosomal homolog 1)
B: fxr (drosophila melanogaster) (fizzy-related (drosophila melanogaster)) (aka fizzy-related)
C: fxr (xenopus tropicalis) (aka nuclear receptor subfamily 1 group h member 4)
D: fxr (homo sapiens) (aka nuclear receptor subfamily 1 group h member 4... | E |
<Instruct>: Given the context 'These novel proteins interact with FMRP and with each other and they are also associated with the 60S ribosomal subunit.', select the correct biomedical concept corresponding to 'fmrp'. Answer using one of the provided options. | <Options>: A: fmrp (xenopus tropicalis) (aka fragile x messenger ribonucleoprotein 1)
B: fmrp (homo sapiens) (aka fragile x messenger ribonucleoprotein 1)
C: fmr1 autosomal homolog 1 (xenopus tropicalis) (frx1l (xenopus tropicalis)) (aka fmr1 autosomal homolog 1)
D: fmr1 autosomal homolog 1 (homo sapiens) (aka fmr1 aut... | B |
<Instruct>: Given the context 'In adult brain, FMR1, FXR1 and FXR2 proteins are coexpressed in the cytoplasm of specific differentiated neurons only.', select the correct biomedical concept corresponding to 'fmr1'. Answer using one of the provided options. | <Options>: A: fmr1 (drosophila melanogaster) (aka fragile x messenger ribonucleoprotein 1)
B: fmr1 autosomal homolog 1 (xenopus tropicalis) (xtfxr1p-a (xenopus tropicalis)) (aka fmr1 autosomal homolog 1)
C: fmr1 (homo sapiens) (fragile site, folic acid type, rare, fra(x)(q27.3) a (homo sapiens)) (aka fragile site, foli... | F |
<Instruct>: Given the context 'In adult brain, FMR1, FXR1 and FXR2 proteins are coexpressed in the cytoplasm of specific differentiated neurons only.', select the correct biomedical concept corresponding to 'fxr1'. Answer using one of the provided options. | <Options>: A: fxr (xenopus tropicalis) (aka nuclear receptor subfamily 1 group h member 4)
B: fxr1 (xenopus tropicalis) (aka fmr1 autosomal homolog 1)
C: fxr (homo sapiens) (aka nuclear receptor subfamily 1 group h member 4)
D: fxr1-a (xenopus laevis) (fmr1 autosomal homolog 1 l homeolog (xenopus laevis)) (aka fmr1 aut... | E |
<Instruct>: Given the context 'In adult brain, FMR1, FXR1 and FXR2 proteins are coexpressed in the cytoplasm of specific differentiated neurons only.', select the correct biomedical concept corresponding to 'fxr2'. Answer using one of the provided options. | <Options>: A: fxr2 (homo sapiens) (aka fmr1 autosomal homolog 2)
B: fxr1-b (xenopus laevis) (fmr1 autosomal homolog 1 s homeolog (xenopus laevis)) (aka fmr1 autosomal homolog 1 s homeolog)
C: fxr (xenopus tropicalis) (aka nuclear receptor subfamily 1 group h member 4)
D: fxr1-b (xenopus tropicalis) (aka fmr1 autosomal ... | A |
<Instruct>: Given the context 'PHOG, a candidate gene for involvement in the short stature of Turner syndrome.
', select the correct biomedical concept corresponding to 'phog'. Answer using one of the provided options. | <Options>: A: phop (escherichia coli str. k-12 substr. mg1655) (aka dna-binding transcriptional dual regulator phop)
B: pho85 (saccharomyces cerevisiae s288c) (aka cyclin-dependent serine/threonine-protein kinase pho85)
C: pho9 (saccharomyces cerevisiae s288c) (aka proteinase a)
D: phog1 (homo sapiens) (aka shox homeob... | D |
<Instruct>: Given the context 'We have named the gene PHOG, for pseudoautosomal homeobox-containing osteogenic gene.', select the correct biomedical concept corresponding to 'phog'. Answer using one of the provided options. | <Options>: A: phop (escherichia coli str. k-12 substr. mg1655) (aka dna-binding transcriptional dual regulator phop)
B: phog1 (homo sapiens) (aka shox homeobox)
C: pho85 (saccharomyces cerevisiae s288c) (aka cyclin-dependent serine/threonine-protein kinase pho85)
D: phosphoglycolate phosphatase (homo sapiens) (aka phos... | B |
<Instruct>: Given the context 'We have named the gene PHOG, for pseudoautosomal homeobox-containing osteogenic gene.', select the correct biomedical concept corresponding to 'pseudoautosomal homeobox-containing osteogenic gene'. Answer using one of the provided options. | <Options>: A: sulfite oxidase pseudogene (homo sapiens) (aka sulfite oxidase pseudogene)
B: sebox homeobox (homo sapiens) (aka sebox homeobox)
C: osteoglycin s homeolog (xenopus laevis) (aka osteoglycin s homeolog)
D: shoxy (homo sapiens) (aka shox homeobox)
E: meiotic recombination hotspot shox (homo sapiens) (aka mei... | D |
<Instruct>: Given the context 'We have named the gene PHOG, for pseudoautosomal homeobox-containing osteogenic gene.', select the correct biomedical concept corresponding to 'pseudoautosomal homeobox-containing osteogenic gene'. Answer using one of the provided options. | <Options>: A: ooep-as (homo sapiens) (aka ooep antisense rna 1)
B: sebox homeobox (homo sapiens) (aka sebox homeobox)
C: osteoglycin s homeolog (xenopus laevis) (aka osteoglycin s homeolog)
D: sulfite oxidase pseudogene (homo sapiens) (aka sulfite oxidase pseudogene)
E: shox homeobox s homeolog (xenopus laevis) (aka sh... | F |
<Instruct>: Given the context 'Its deletion in patients with short stature, the predicted altered dosage in 45,X individuals, along with the nature of the encoded protein and its expression pattern, make PHOG an attractive candidate for involvement in the short stature of Turner syndrome.', select the correct biomedica... | <Options>: A: phog1 (homo sapiens) (aka shox homeobox)
B: phoh (escherichia coli str. k-12 substr. mg1655) (aka atp-binding protein phoh)
C: phosphoglycolate phosphatase (homo sapiens) (aka phosphoglycolate phosphatase)
D: phop (escherichia coli str. k-12 substr. mg1655) (aka dna-binding transcriptional dual regulator ... | A |
<Instruct>: Given the context 'We have also found that the mouse homolog of PHOG is autosomal, which may help to explain the lack of a growth abnormality in mice with monosomy X.', select the correct biomedical concept corresponding to 'phog'. Answer using one of the provided options. | <Options>: A: pp2cg (homo sapiens) (aka protein phosphatase, mg2+/mn2+ dependent 1g)
B: phog1 (homo sapiens) (aka shox homeobox)
C: phoh (escherichia coli str. k-12 substr. mg1655) (aka atp-binding protein phoh)
D: pho85 (saccharomyces cerevisiae s288c) (aka cyclin-dependent serine/threonine-protein kinase pho85)
E: ph... | B |
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