instruction stringlengths 169 712 | input stringlengths 140 808 | response stringclasses 6
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<Instruct>: Given the context 'Herein we report the cDNA cloning of a human brain 25 kDa lysophospholipid-specific lysophospholipase (hLysoPLA).', select the correct biomedical concept corresponding to 'lysophospholipid-specific lysophospholipase'. Answer using one of the provided options. | <Options>: A: patatin like domain 7, lysophospholipase (homo sapiens) (aka patatin like domain 7, lysophospholipase)
B: lysophospholipase-like 1 (xenopus tropicalis) (aka lysophospholipase-like 1)
C: lysophospholipase 2 l homeolog (xenopus laevis) (aka lysophospholipase 2 l homeolog)
D: lysophospholipase 1 (xenopus tro... | E |
<Instruct>: Given the context 'Herein we report the cDNA cloning of a human brain 25 kDa lysophospholipid-specific lysophospholipase (hLysoPLA).', select the correct biomedical concept corresponding to 'hlysopla'. Answer using one of the provided options. | <Options>: A: lysopld (homo sapiens) (aka ectonucleotide pyrophosphatase/phosphodiesterase 2)
B: lysophospholipase 1 (homo sapiens) (aka lysophospholipase 1)
C: plosl (homo sapiens) (aka transmembrane immune signaling adaptor tyrobp)
D: lpsa (homo sapiens) (aka oncogene liposarcoma (dna segment, single copy, expressed,... | B |
<Instruct>: Given the context 'The hLysoPLA hydrolyzes lysophosphatidylcholine in both monomeric and micellar forms, and exhibits apparent cooperativity and surface dilution kinetics, but not interfacial activation.', select the correct biomedical concept corresponding to 'hlysopla'. Answer using one of the provided op... | <Options>: A: spo (homo sapiens) (lactoperoxidase (homo sapiens)) (aka lactoperoxidase)
B: potocki-lupski syndrome (homo sapiens) (aka potocki-lupski syndrome)
C: lysophospholipase 1 (homo sapiens) (aka lysophospholipase 1)
D: spgyla (homo sapiens) (aka deleted in azoospermia like)
E: lysopld (homo sapiens) (aka ectonu... | C |
<Instruct>: Given the context 'Detailed kinetic analysis indicates that the hLysoPLA binds first to the micellar surface and then to the substrate presented on the surface.', select the correct biomedical concept corresponding to 'hlysopla'. Answer using one of the provided options. | <Options>: A: lysopld (homo sapiens) (aka ectonucleotide pyrophosphatase/phosphodiesterase 2)
B: spgyla (homo sapiens) (aka deleted in azoospermia like)
C: hpo (homo sapiens) (aka growth factor, augmenter of liver regeneration)
D: lysophospholipase 1 (homo sapiens) (aka lysophospholipase 1)
E: lpsa (homo sapiens) (aka ... | D |
<Instruct>: Given the context 'The kinetic parameters associated with this surface dilution kinetic model are reported, and it is concluded that hLysoPLA has a single substrate binding site and a surface recognition site.', select the correct biomedical concept corresponding to 'hlysopla'. Answer using one of the provi... | <Options>: A: lysophospholipase 1 (homo sapiens) (aka lysophospholipase 1)
B: lysopld (homo sapiens) (aka ectonucleotide pyrophosphatase/phosphodiesterase 2)
C: spgyla (homo sapiens) (aka deleted in azoospermia like)
D: splash (homo sapiens) (aka phospholipase a2 group iid)
E: hpo (homo sapiens) (aka growth factor, aug... | A |
<Instruct>: Given the context 'In contrast to many non-specific lipolytic enzymes that exhibit lysophospholipase activity, hLysoPLA hydrolyzes only lysophospholipids and has no other significant enzymatic activity.', select the correct biomedical concept corresponding to 'hlysopla'. Answer using one of the provided opt... | <Options>: A: spgyla (homo sapiens) (aka deleted in azoospermia like)
B: lysophospholipase 1 (homo sapiens) (aka lysophospholipase 1)
C: plosl (homo sapiens) (aka transmembrane immune signaling adaptor tyrobp)
D: ospl (homo sapiens) (aka claudin 10)
E: hpo (homo sapiens) (aka growth factor, augmenter of liver regenerat... | B |
<Instruct>: Given the context 'Of special interest, hLysoPLA does not act on plasmenylcholine.', select the correct biomedical concept corresponding to 'hlysopla'. Answer using one of the provided options. | <Options>: A: splash (homo sapiens) (aka phospholipase a2 group iid)
B: lysophospholipase 1 (homo sapiens) (aka lysophospholipase 1)
C: lysopld (homo sapiens) (aka ectonucleotide pyrophosphatase/phosphodiesterase 2)
D: plosl (homo sapiens) (aka transmembrane immune signaling adaptor tyrobp)
E: spo (homo sapiens) (lacto... | B |
<Instruct>: Given the context 'Functional domains of the SYT and SYT-SSX synovial sarcoma translocation proteins and co-localization with the SNF protein BRM in the nucleus.
', select the correct biomedical concept corresponding to 'syt'. Answer using one of the provided options. | <Options>: A: syt1 (xenopus tropicalis) (aka synaptotagmin 1)
B: synaptoporin (xenopus tropicalis) (aka synaptoporin)
C: syt (xenopus laevis) (synaptotagmin 1 s homeolog (xenopus laevis)) (aka synaptotagmin 1 s homeolog)
D: syt1 (homo sapiens) (aka synaptotagmin 1)
E: syn (drosophila melanogaster) (synaptotagmin 1 (dro... | F |
<Instruct>: Given the context 'Functional domains of the SYT and SYT-SSX synovial sarcoma translocation proteins and co-localization with the SNF protein BRM in the nucleus.
', select the correct biomedical concept corresponding to 'syt'. Answer using one of the provided options. | <Options>: A: synaptotagmin-1 (xenopus tropicalis) (aka synaptotagmin-1)
B: syt1 (homo sapiens) (aka synaptotagmin 1)
C: syt (xenopus laevis) (synaptotagmin 1 s homeolog (xenopus laevis)) (aka synaptotagmin 1 s homeolog)
D: synaptoporin (xenopus tropicalis) (aka synaptoporin)
E: syt (xenopus tropicalis) (aka synaptotag... | F |
<Instruct>: Given the context 'Functional domains of the SYT and SYT-SSX synovial sarcoma translocation proteins and co-localization with the SNF protein BRM in the nucleus.
', select the correct biomedical concept corresponding to 'brm'. Answer using one of the provided options. | <Options>: A: brt (mus musculus) (aka tyro3 protein tyrosine kinase 3)
B: mbr (homo sapiens) (aka translocator protein)
C: brm (homo sapiens) (aka swi/snf related baf chromatin remodeling complex subunit atpase 2)
D: brx1, biogenesis of ribosomes (mus musculus) (aka brx1, biogenesis of ribosomes)
E: br (mus musculus) (... | C |
<Instruct>: Given the context 'Functional domains of the SYT and SYT-SSX synovial sarcoma translocation proteins and co-localization with the SNF protein BRM in the nucleus.
', select the correct biomedical concept corresponding to 'brm'. Answer using one of the provided options. | <Options>: A: brms1 like transcriptional repressor (bos taurus) (aka brms1 like transcriptional repressor)
B: brx1, biogenesis of ribosomes (mus musculus) (aka brx1, biogenesis of ribosomes)
C: brm (mus musculus) (aka swi/snf related baf chromatin remodeling complex subunit atpase 2)
D: brp (mus musculus) (aka growth d... | F |
<Instruct>: Given the context 'The t(X;18)(p11.2;q11.2) chromosomal translocation commonly found in synovial sarcomas fuses the SYT gene on chromosome 18 to either of two similar genes, SSX1 or SSX2, on the X chromosome.', select the correct biomedical concept corresponding to 'syt'. Answer using one of the provided op... | <Options>: A: syt1 (xenopus tropicalis) (aka synaptotagmin 1)
B: synaptoporin (xenopus tropicalis) (aka synaptoporin)
C: syn (drosophila melanogaster) (synaptotagmin 1 (drosophila melanogaster)) (aka synaptotagmin 1)
D: synaptotagmin-1 (xenopus tropicalis) (aka synaptotagmin-1)
E: syt (xenopus laevis) (synaptotagmin 1 ... | F |
<Instruct>: Given the context 'The t(X;18)(p11.2;q11.2) chromosomal translocation commonly found in synovial sarcomas fuses the SYT gene on chromosome 18 to either of two similar genes, SSX1 or SSX2, on the X chromosome.', select the correct biomedical concept corresponding to 'ssx1'. Answer using one of the provided o... | <Options>: A: ssx family member 1 (homo sapiens) (aka ssx family member 1)
B: srpx1 (xenopus laevis) (sushi repeat containing protein x-linked s homeolog (xenopus laevis)) (aka sushi repeat containing protein x-linked s homeolog)
C: slx1 homolog a, structure-specific endonuclease subunit (xenopus tropicalis) (aka slx1 ... | A |
<Instruct>: Given the context 'The t(X;18)(p11.2;q11.2) chromosomal translocation commonly found in synovial sarcomas fuses the SYT gene on chromosome 18 to either of two similar genes, SSX1 or SSX2, on the X chromosome.', select the correct biomedical concept corresponding to 'ssx2'. Answer using one of the provided o... | <Options>: A: sox-2 (xenopus laevis) (sry-box 2 s homeolog (xenopus laevis)) (aka sry-box 2 s homeolog)
B: ssx family member 2 (homo sapiens) (aka ssx family member 2)
C: protein ssuh2 homolog (xenopus laevis) (aka protein ssuh2 homolog)
D: ssx2 (saccharomyces cerevisiae s288c) (aka rox3p)
E: ssxp2 (homo sapiens) (aka ... | B |
<Instruct>: Given the context 'The SYT protein appears to act as a transcriptional co-activator and the SSX proteins as co-repressors.', select the correct biomedical concept corresponding to 'syt'. Answer using one of the provided options. | <Options>: A: syt (xenopus laevis) (synaptotagmin 1 s homeolog (xenopus laevis)) (aka synaptotagmin 1 s homeolog)
B: synaptotagmin-1 (xenopus tropicalis) (aka synaptotagmin-1)
C: syt (xenopus tropicalis) (aka synaptotagmin 1)
D: syt-vii (homo sapiens) (aka synaptotagmin 7)
E: syn (drosophila melanogaster) (synaptotagmi... | F |
<Instruct>: Given the context 'The SYT protein has a novel conserved 54 amino acid domain at the N-terminus of the protein (the SNH domain) which is found in proteins from a wide variety of species, and a C-terminal domain, rich in glutamine, proline, glycine and tyrosine (the QPGY domain), which contains the transcrip... | <Options>: A: synaptoporin (xenopus tropicalis) (aka synaptoporin)
B: syt1 (homo sapiens) (aka synaptotagmin 1)
C: syt-vii (homo sapiens) (aka synaptotagmin 7)
D: synaptotagmin-1 (xenopus tropicalis) (aka synaptotagmin-1)
E: synaptotagmin 1 (xenopus tropicalis) (aka synaptotagmin 1)
F: None of the above. | F |
<Instruct>: Given the context 'The C-terminal SSX domain present in SYT-SSX translocation protein contributes a transcriptional repressor domain to the protein.', select the correct biomedical concept corresponding to 'syt'. Answer using one of the provided options. | <Options>: A: synaptoporin (xenopus tropicalis) (aka synaptoporin)
B: synaptotagmin-1 (xenopus tropicalis) (aka synaptotagmin-1)
C: syt1 (homo sapiens) (aka synaptotagmin 1)
D: syt (xenopus laevis) (synaptotagmin 1 s homeolog (xenopus laevis)) (aka synaptotagmin 1 s homeolog)
E: syn (drosophila melanogaster) (synaptota... | F |
<Instruct>: Given the context 'We demonstrate that the human homologue of the SNF2/Brahama protein BRM co-localizes with SYT and SYT-SSX in nuclear speckles, and also interacts with SYT and SYT-SSX proteins in vitro.', select the correct biomedical concept corresponding to 'snf2'. Answer using one of the provided optio... | <Options>: A: snf2l (homo sapiens) (aka snf2 related chromatin remodeling atpase 1)
B: snf2-beta (homo sapiens) (aka swi/snf related baf chromatin remodeling complex subunit atpase 4)
C: snf1 (saccharomyces cerevisiae s288c) (aka amp-activated serine/threonine-protein kinase catalytic subunit snf1)
D: snf2l2 (homo sapi... | D |
<Instruct>: Given the context 'We demonstrate that the human homologue of the SNF2/Brahama protein BRM co-localizes with SYT and SYT-SSX in nuclear speckles, and also interacts with SYT and SYT-SSX proteins in vitro.', select the correct biomedical concept corresponding to 'brahama'. Answer using one of the provided op... | <Options>: A: nedeba (homo sapiens) (aka atpase h+ transporting v0 subunit a1)
B: transmembrane protein 179ba (danio rerio) (aka transmembrane protein 179ba)
C: brd (drosophila melanogaster) (brahma (drosophila melanogaster)) (aka brahma)
D: bravo (arabidopsis thaliana) (aka myb domain protein 56)
E: bora, aurora kinas... | F |
<Instruct>: Given the context 'We demonstrate that the human homologue of the SNF2/Brahama protein BRM co-localizes with SYT and SYT-SSX in nuclear speckles, and also interacts with SYT and SYT-SSX proteins in vitro.', select the correct biomedical concept corresponding to 'brm'. Answer using one of the provided option... | <Options>: A: brm (mus musculus) (aka swi/snf related baf chromatin remodeling complex subunit atpase 2)
B: brm (homo sapiens) (aka swi/snf related baf chromatin remodeling complex subunit atpase 2)
C: brm1 (mus musculus) (aka brachyury modifier 1)
D: brm (drosophila melanogaster) (aka brahma)
E: brt (mus musculus) (ak... | B |
<Instruct>: Given the context 'We demonstrate that the human homologue of the SNF2/Brahama protein BRM co-localizes with SYT and SYT-SSX in nuclear speckles, and also interacts with SYT and SYT-SSX proteins in vitro.', select the correct biomedical concept corresponding to 'syt'. Answer using one of the provided option... | <Options>: A: syt (xenopus laevis) (synaptotagmin 1 s homeolog (xenopus laevis)) (aka synaptotagmin 1 s homeolog)
B: syn (drosophila melanogaster) (synaptotagmin 1 (drosophila melanogaster)) (aka synaptotagmin 1)
C: synaptotagmin-1 (xenopus tropicalis) (aka synaptotagmin-1)
D: syt1 (homo sapiens) (aka synaptotagmin 1)
... | F |
<Instruct>: Given the context 'We demonstrate that the human homologue of the SNF2/Brahama protein BRM co-localizes with SYT and SYT-SSX in nuclear speckles, and also interacts with SYT and SYT-SSX proteins in vitro.', select the correct biomedical concept corresponding to 'syt'. Answer using one of the provided option... | <Options>: A: syt (xenopus laevis) (synaptotagmin 1 s homeolog (xenopus laevis)) (aka synaptotagmin 1 s homeolog)
B: synaptoporin (xenopus tropicalis) (aka synaptoporin)
C: synaptotagmin 1 (xenopus tropicalis) (aka synaptotagmin 1)
D: syn (drosophila melanogaster) (synaptotagmin 1 (drosophila melanogaster)) (aka synapt... | F |
<Instruct>: Given the context 'We demonstrate that the human homologue of the SNF2/Brahama protein BRM co-localizes with SYT and SYT-SSX in nuclear speckles, and also interacts with SYT and SYT-SSX proteins in vitro.', select the correct biomedical concept corresponding to 'syt'. Answer using one of the provided option... | <Options>: A: syt1 (homo sapiens) (aka synaptotagmin 1)
B: syn (drosophila melanogaster) (synaptotagmin 1 (drosophila melanogaster)) (aka synaptotagmin 1)
C: syt7 (homo sapiens) (aka synaptotagmin 7)
D: syt (xenopus laevis) (synaptotagmin 1 s homeolog (xenopus laevis)) (aka synaptotagmin 1 s homeolog)
E: synaptotagmin-... | F |
<Instruct>: Given the context 'We demonstrate that the human homologue of the SNF2/Brahama protein BRM co-localizes with SYT and SYT-SSX in nuclear speckles, and also interacts with SYT and SYT-SSX proteins in vitro.', select the correct biomedical concept corresponding to 'syt'. Answer using one of the provided option... | <Options>: A: synaptoporin (xenopus tropicalis) (aka synaptoporin)
B: syt (xenopus laevis) (synaptotagmin 1 s homeolog (xenopus laevis)) (aka synaptotagmin 1 s homeolog)
C: syn (drosophila melanogaster) (synaptotagmin 1 (drosophila melanogaster)) (aka synaptotagmin 1)
D: syt-vii (homo sapiens) (aka synaptotagmin 7)
E: ... | F |
<Instruct>: Given the context 'We demonstrate that the human homologue of the SNF2/Brahama protein BRM co-localizes with SYT and SYT-SSX in nuclear speckles, and also interacts with SYT and SYT-SSX proteins in vitro.', select the correct biomedical concept corresponding to 'syt'. Answer using one of the provided option... | <Options>: A: synaptotagmin-1 (xenopus tropicalis) (aka synaptotagmin-1)
B: synaptoporin (xenopus tropicalis) (aka synaptoporin)
C: syn (drosophila melanogaster) (synaptotagmin 1 (drosophila melanogaster)) (aka synaptotagmin 1)
D: syt1 (xenopus tropicalis) (aka synaptotagmin 1)
E: syt-vii (homo sapiens) (aka synaptotag... | F |
<Instruct>: Given the context 'This interaction may provide an explanation of how the SYT protein activates gene transcription.', select the correct biomedical concept corresponding to 'syt'. Answer using one of the provided options. | <Options>: A: syn (drosophila melanogaster) (synaptotagmin 1 (drosophila melanogaster)) (aka synaptotagmin 1)
B: synaptotagmin-1 (xenopus tropicalis) (aka synaptotagmin-1)
C: syt7 (homo sapiens) (aka synaptotagmin 7)
D: syt1 (xenopus tropicalis) (aka synaptotagmin 1)
E: syt1 (homo sapiens) (aka synaptotagmin 1)
F: None... | F |
<Instruct>: Given the context 'Identification and expression of delta-isoforms of the multifunctional Ca2+/calmodulin-dependent protein kinase in failing and nonfailing human myocardium.
', select the correct biomedical concept corresponding to 'delta-isoforms of the multifunctional ca2+/calmodulin-dependent protein ki... | <Options>: A: protein kinase c delta (drosophila melanogaster) (aka protein kinase c delta)
B: camk2d (homo sapiens) (aka calcium/calmodulin dependent protein kinase ii delta)
C: calcium/calmodulin-dependent protein kinase ii, delta (mus musculus) (aka calcium/calmodulin-dependent protein kinase ii, delta)
D: protein k... | B |
<Instruct>: Given the context 'In this study, we investigated the spectrum of CaMKII isoforms delta2, delta3, delta4, delta8, and delta9 in human striated muscle tissue.', select the correct biomedical concept corresponding to 'camkii isoforms delta2, delta3, delta4, delta8, and delta9'. Answer using one of the provide... | <Options>: A: camk2d (homo sapiens) (aka calcium/calmodulin dependent protein kinase ii delta)
B: cki-delta (homo sapiens) (aka casein kinase 1 delta)
C: camkiid (drosophila melanogaster) (aka calcium/calmodulin-dependent protein kinase ii)
D: camkiinalpha (homo sapiens) (aka calcium/calmodulin dependent protein kinase... | A |
<Instruct>: Given the context 'relative to the expression of glyceraldehyde-3-phosphate dehydrogenase in diseased hearts (101. 6+/-11.0% versus 64.9+/-9.9% in the nonfailing group; P < 0.05, n=6).', select the correct biomedical concept corresponding to 'glyceraldehyde-3-phosphate dehydrogenase'. Answer using one of th... | <Options>: A: glyceraldehyde-3-phosphate dehydrogenase, spermatogenic (homo sapiens) (aka glyceraldehyde-3-phosphate dehydrogenase, spermatogenic)
B: glyceraldehyde 3 phosphate dehydrogenase 1 (drosophila melanogaster) (aka glyceraldehyde 3 phosphate dehydrogenase 1)
C: gapdh (homo sapiens) (glyceraldehyde-3-phosphate ... | C |
<Instruct>: Given the context 'At the protein level, by using a subclass-specific antibody, we observed a similar increase of a delta-CaMKII-specific signal (7.2+/-1.0 versus 3.8+/-0.7 optical density units in the nonfailing group; P < 0.05, n=4 through 6).', select the correct biomedical concept corresponding to 'delt... | <Options>: A: camkiid (drosophila melanogaster) (aka calcium/calmodulin-dependent protein kinase ii)
B: calcium/calmodulin-dependent protein kinase ii, delta (mus musculus) (aka calcium/calmodulin-dependent protein kinase ii, delta)
C: camkii (xenopus tropicalis) (calcium/calmodulin dependent protein kinase (cam kinase... | D |
<Instruct>: Given the context 'Our data characterize for the first time the delta-CaMKII isoform expression pattern in human hearts and demonstrate changes in this expression pattern in heart failure.', select the correct biomedical concept corresponding to 'delta-camkii'. Answer using one of the provided options. | <Options>: A: camkii (xenopus tropicalis) (calcium/calmodulin dependent protein kinase (cam kinase) ii delta (xenopus tropicalis)) (aka calcium/calmodulin dependent protein kinase (cam kinase) ii delta)
B: camkiid (drosophila melanogaster) (aka calcium/calmodulin-dependent protein kinase ii)
C: [d]-camkii (mus musculus... | D |
<Instruct>: Given the context 'Cloning and sequencing of the complete cDNA encoding the human insulin receptor related receptor.
', select the correct biomedical concept corresponding to 'insulin receptor related receptor'. Answer using one of the provided options. | <Options>: A: insulin receptor (homo sapiens) (aka insulin receptor)
B: insulin receptor related receptor (sus scrofa) (aka insulin receptor related receptor)
C: insulin receptor-related receptor (rattus norvegicus) (aka insulin receptor-related receptor)
D: insulin receptor-related receptor (mus musculus) (aka insulin... | E |
<Instruct>: Given the context 'Cloning and sequencing of the complete cDNA encoding the human insulin receptor related receptor.
', select the correct biomedical concept corresponding to 'insulin receptor related receptor'. Answer using one of the provided options. | <Options>: A: insr (homo sapiens) (aka insulin receptor)
B: insulin receptor related receptor (sus scrofa) (aka insulin receptor related receptor)
C: insulin receptor related receptor (xenopus tropicalis) (aka insulin receptor related receptor)
D: insulin receptor-related receptor (rattus norvegicus) (aka insulin recep... | F |
<Instruct>: Given the context 'The insulin receptor related receptor (IRR) is a heterotetrameric transmembrane receptor with intrinsic tyrosine kinase activity.', select the correct biomedical concept corresponding to 'insulin receptor related receptor'. Answer using one of the provided options. | <Options>: A: insulin receptor related receptor (xenopus tropicalis) (aka insulin receptor related receptor)
B: insr (homo sapiens) (aka insulin receptor)
C: insulin receptor related receptor (homo sapiens) (aka insulin receptor related receptor)
D: insulin receptor-related receptor (mus musculus) (aka insulin receptor... | C |
<Instruct>: Given the context 'The insulin receptor related receptor (IRR) is a heterotetrameric transmembrane receptor with intrinsic tyrosine kinase activity.', select the correct biomedical concept corresponding to 'irr'. Answer using one of the provided options. | <Options>: A: irr (homo sapiens) (aka insulin receptor related receptor)
B: ip10-r (homo sapiens) (aka c-x-c motif chemokine receptor 3)
C: insr (homo sapiens) (aka insulin receptor)
D: ifnr (homo sapiens) (aka interferon production regulator)
E: il1r (homo sapiens) (aka interleukin 1 receptor type 1)
F: None of the ab... | A |
<Instruct>: Given the context 'The IRR shares large homology with the insulin and the insulin-like growth factor-1 (IGF-I) receptor with regard to amino acid sequence and protein structure.', select the correct biomedical concept corresponding to 'irr'. Answer using one of the provided options. | <Options>: A: ip10-r (homo sapiens) (aka c-x-c motif chemokine receptor 3)
B: il1r (homo sapiens) (aka interleukin 1 receptor type 1)
C: ifngr1 (homo sapiens) (aka interferon gamma receptor 1)
D: il1r3 (homo sapiens) (aka interleukin 1 receptor accessory protein)
E: insrr (homo sapiens) (aka insulin receptor related re... | E |
<Instruct>: Given the context 'So far, only a partial human sequence containing the complete 3' end has been reported, although the full-length human IRR cDNA had been used for transfection studies and functional analysis of the receptor.', select the correct biomedical concept corresponding to 'irr'. Answer using one ... | <Options>: A: insr (homo sapiens) (aka insulin receptor)
B: insulin receptor related receptor (homo sapiens) (aka insulin receptor related receptor)
C: ifnr (homo sapiens) (aka interferon production regulator)
D: il1r3 (homo sapiens) (aka interleukin 1 receptor accessory protein)
E: ip10-r (homo sapiens) (aka c-x-c mot... | B |
<Instruct>: Given the context 'We have isolated a full-length human IRR cDNA and report on the 5' translated and untranslated region of the human IRR gene.', select the correct biomedical concept corresponding to 'irr'. Answer using one of the provided options. | <Options>: A: insulin receptor related receptor (homo sapiens) (aka insulin receptor related receptor)
B: ip10-r (homo sapiens) (aka c-x-c motif chemokine receptor 3)
C: ifnr (homo sapiens) (aka interferon production regulator)
D: ifngr1 (homo sapiens) (aka interferon gamma receptor 1)
E: il1r3 (homo sapiens) (aka inte... | A |
<Instruct>: Given the context 'We have isolated a full-length human IRR cDNA and report on the 5' translated and untranslated region of the human IRR gene.', select the correct biomedical concept corresponding to 'irr'. Answer using one of the provided options. | <Options>: A: il1r3 (homo sapiens) (aka interleukin 1 receptor accessory protein)
B: insulin receptor related receptor (homo sapiens) (aka insulin receptor related receptor)
C: ifnr (homo sapiens) (aka interferon production regulator)
D: ip10-r (homo sapiens) (aka c-x-c motif chemokine receptor 3)
E: ifngr1 (homo sapie... | B |
<Instruct>: Given the context 'The full length IRR sequence contains 4150 bases and shares a high degree of homology with the guinea pig IRR cDNA sequence and rat IRR sequences that had been reported earlier on by others.', select the correct biomedical concept corresponding to 'irr'. Answer using one of the provided o... | <Options>: A: insrr (homo sapiens) (aka insulin receptor related receptor)
B: ifnr (homo sapiens) (aka interferon production regulator)
C: il1r (homo sapiens) (aka interleukin 1 receptor type 1)
D: il1r3 (homo sapiens) (aka interleukin 1 receptor accessory protein)
E: ip10-r (homo sapiens) (aka c-x-c motif chemokine re... | A |
<Instruct>: Given the context 'The full length IRR sequence contains 4150 bases and shares a high degree of homology with the guinea pig IRR cDNA sequence and rat IRR sequences that had been reported earlier on by others.', select the correct biomedical concept corresponding to 'irr'. Answer using one of the provided o... | <Options>: A: il1r (homo sapiens) (aka interleukin 1 receptor type 1)
B: ifnr (homo sapiens) (aka interferon production regulator)
C: ip10-r (homo sapiens) (aka c-x-c motif chemokine receptor 3)
D: ifngr (homo sapiens) (aka interferon gamma receptor 1)
E: il1r3 (homo sapiens) (aka interleukin 1 receptor accessory prote... | F |
<Instruct>: Given the context 'The full length IRR sequence contains 4150 bases and shares a high degree of homology with the guinea pig IRR cDNA sequence and rat IRR sequences that had been reported earlier on by others.', select the correct biomedical concept corresponding to 'irr'. Answer using one of the provided o... | <Options>: A: il1r3 (homo sapiens) (aka interleukin 1 receptor accessory protein)
B: insr (homo sapiens) (aka insulin receptor)
C: ifnr (homo sapiens) (aka interferon production regulator)
D: irr (homo sapiens) (aka insulin receptor related receptor)
E: ip10-r (homo sapiens) (aka c-x-c motif chemokine receptor 3)
F: No... | F |
<Instruct>: Given the context 'Sequencing of the IRR cDNA revealed that the human IRR cDNA contains 341 bases corresponding to the IRR 5' end in addition to the bases that had been reported on before.', select the correct biomedical concept corresponding to 'irr'. Answer using one of the provided options. | <Options>: A: ifnr (homo sapiens) (aka interferon production regulator)
B: ifngr (homo sapiens) (aka interferon gamma receptor 1)
C: irr (homo sapiens) (aka insulin receptor related receptor)
D: ip10-r (homo sapiens) (aka c-x-c motif chemokine receptor 3)
E: il1r (homo sapiens) (aka interleukin 1 receptor type 1)
F: No... | C |
<Instruct>: Given the context 'Sequencing of the IRR cDNA revealed that the human IRR cDNA contains 341 bases corresponding to the IRR 5' end in addition to the bases that had been reported on before.', select the correct biomedical concept corresponding to 'irr'. Answer using one of the provided options. | <Options>: A: insr (homo sapiens) (aka insulin receptor)
B: il1r (homo sapiens) (aka interleukin 1 receptor type 1)
C: ifnr (homo sapiens) (aka interferon production regulator)
D: ip10-r (homo sapiens) (aka c-x-c motif chemokine receptor 3)
E: ifngr1 (homo sapiens) (aka interferon gamma receptor 1)
F: None of the above... | F |
<Instruct>: Given the context 'Sequencing of the IRR cDNA revealed that the human IRR cDNA contains 341 bases corresponding to the IRR 5' end in addition to the bases that had been reported on before.', select the correct biomedical concept corresponding to 'irr'. Answer using one of the provided options. | <Options>: A: insr (homo sapiens) (aka insulin receptor)
B: ifngr1 (homo sapiens) (aka interferon gamma receptor 1)
C: il1r3 (homo sapiens) (aka interleukin 1 receptor accessory protein)
D: ifnr (homo sapiens) (aka interferon production regulator)
E: irr (homo sapiens) (aka insulin receptor related receptor)
F: None of... | E |
<Instruct>: Given the context 'Sequencing of the IRR cDNA revealed that the human IRR cDNA contains 341 bases corresponding to the IRR 5' end in addition to the bases that had been reported on before.', select the correct biomedical concept corresponding to 'irr'. Answer using one of the provided options. | <Options>: A: insr (homo sapiens) (aka insulin receptor)
B: ifngr1 (homo sapiens) (aka interferon gamma receptor 1)
C: ip10-r (homo sapiens) (aka c-x-c motif chemokine receptor 3)
D: ifnr (homo sapiens) (aka interferon production regulator)
E: insulin receptor related receptor (homo sapiens) (aka insulin receptor relat... | E |
<Instruct>: Given the context 'The full length cDNA for the human IRR can now be used for functional expression studies and to elucidate the nature of the ligand for this receptor type.', select the correct biomedical concept corresponding to 'irr'. Answer using one of the provided options. | <Options>: A: il1r3 (homo sapiens) (aka interleukin 1 receptor accessory protein)
B: ifnr (homo sapiens) (aka interferon production regulator)
C: insrr (homo sapiens) (aka insulin receptor related receptor)
D: ip10-r (homo sapiens) (aka c-x-c motif chemokine receptor 3)
E: il1r (homo sapiens) (aka interleukin 1 recepto... | C |
<Instruct>: Given the context 'The deduced amino acids sequence shows an overall homology of 48% with the human renal NPT1 protein.', select the correct biomedical concept corresponding to 'npt1'. Answer using one of the provided options. | <Options>: A: solute carrier family 1 member 2 (homo sapiens) (aka solute carrier family 1 member 2)
B: solute carrier family 11 member 1 (homo sapiens) (aka solute carrier family 11 member 1)
C: slc-1 (homo sapiens) (aka melanin concentrating hormone receptor 1)
D: npt1 (homo sapiens) (aka solute carrier family 17 mem... | D |
<Instruct>: Given the context 'Thus, this gene may code for intestinal type NPT or closely related proteins.', select the correct biomedical concept corresponding to 'intestinal type npt'. Answer using one of the provided options. | <Options>: A: npt2 (rattus norvegicus) (aka solute carrier family 34 member 1)
B: nptn (homo sapiens) (aka neuroplastin)
C: npt1 (homo sapiens) (aka solute carrier family 17 member 1)
D: npt2 (homo sapiens) (aka solute carrier family 34 member 1)
E: npnt (homo sapiens) (aka nephronectin)
F: None of the above. | F |
<Instruct>: Given the context 'Cutting edge: immature dendritic cells generated from monocytes in the presence of TGF-beta 1 express functional C-C chemokine receptor 6.
', select the correct biomedical concept corresponding to 'tgf-beta 1'. Answer using one of the provided options. | <Options>: A: transforming growth factor beta 1 (bos taurus) (aka transforming growth factor beta 1)
B: interferon beta 1 (homo sapiens) (aka interferon beta 1)
C: transforming growth factor beta receptor 1 (homo sapiens) (aka transforming growth factor beta receptor 1)
D: tgfbeta (homo sapiens) (aka transforming growt... | D |
<Instruct>: Given the context 'Cutting edge: immature dendritic cells generated from monocytes in the presence of TGF-beta 1 express functional C-C chemokine receptor 6.
', select the correct biomedical concept corresponding to 'c-c chemokine receptor 6'. Answer using one of the provided options. | <Options>: A: cxcr6 (homo sapiens) (aka c-x-c motif chemokine receptor 6)
B: c-c ckr-6 (homo sapiens) (aka c-c motif chemokine receptor 6)
C: c-c motif chemokine receptor 7 (homo sapiens) (aka c-c motif chemokine receptor 7)
D: cc-ckr-8 (homo sapiens) (aka c-c motif chemokine receptor 8)
E: None of the above. | B |
<Instruct>: Given the context 'Although CD34+ progenitor-derived immature dendritic cells (DCs) express CCR6, several recent studies reported that monocyte-derived immature DCs do not do so.', select the correct biomedical concept corresponding to 'ccr6'. Answer using one of the provided options. | <Options>: A: c-x-c motif chemokine receptor 6 (homo sapiens) (aka c-x-c motif chemokine receptor 6)
B: cmkbr6 (homo sapiens) (aka c-c motif chemokine receptor 6)
C: ccr-8 (homo sapiens) (aka c-c motif chemokine receptor 8)
D: None of the above. | B |
<Instruct>: Given the context 'We observed that DCs generated from monocytes in the presence of GM-CSF, IL-4, and TGF-beta 1 consistently responded to liver and activation-regulated chemokine (LARC, also known as macrophage inflammatory protein-3 alpha).', select the correct biomedical concept corresponding to 'gm-csf'... | <Options>: A: csf (homo sapiens) (colony stimulating factor 2 (homo sapiens)) (aka colony stimulating factor 2)
B: csf1 (homo sapiens) (aka colony stimulating factor 1)
C: colony stimulating factor 3 (homo sapiens) (aka colony stimulating factor 3)
D: gm-csf (mus musculus) (aka colony stimulating factor 2 (granulocyte-... | A |
<Instruct>: Given the context 'We observed that DCs generated from monocytes in the presence of GM-CSF, IL-4, and TGF-beta 1 consistently responded to liver and activation-regulated chemokine (LARC, also known as macrophage inflammatory protein-3 alpha).', select the correct biomedical concept corresponding to 'il-4'. ... | <Options>: A: bllf1 (human gammaherpesvirus 4) (aka glycoprotein 350)
B: bdlf4 (human gammaherpesvirus 4) (aka protein ul92)
C: bolf1 (human gammaherpesvirus 4) (aka tegument protein ul37)
D: interleukin 5 (homo sapiens) (aka interleukin 5)
E: interleukin 4 (homo sapiens) (aka interleukin 4)
F: None of the above. | E |
<Instruct>: Given the context 'We observed that DCs generated from monocytes in the presence of GM-CSF, IL-4, and TGF-beta 1 consistently responded to liver and activation-regulated chemokine (LARC, also known as macrophage inflammatory protein-3 alpha).', select the correct biomedical concept corresponding to 'il-4'. ... | <Options>: A: interleukin 5 (homo sapiens) (aka interleukin 5)
B: bdlf4 (human gammaherpesvirus 4) (aka protein ul92)
C: bolf1 (human gammaherpesvirus 4) (aka tegument protein ul37)
D: interleukin 4 (bos taurus) (aka interleukin 4)
E: bllf1 (human gammaherpesvirus 4) (aka glycoprotein 350)
F: None of the above. | F |
<Instruct>: Given the context 'We observed that DCs generated from monocytes in the presence of GM-CSF, IL-4, and TGF-beta 1 consistently responded to liver and activation-regulated chemokine (LARC, also known as macrophage inflammatory protein-3 alpha).', select the correct biomedical concept corresponding to 'tgf-bet... | <Options>: A: transforming growth factor beta receptor 1 (homo sapiens) (aka transforming growth factor beta receptor 1)
B: tgf-beta1 (homo sapiens) (aka transforming growth factor beta 1)
C: transforming growth factor beta 1 (bos taurus) (aka transforming growth factor beta 1)
D: interferon beta 1 (homo sapiens) (aka ... | B |
<Instruct>: Given the context 'We observed that DCs generated from monocytes in the presence of GM-CSF, IL-4, and TGF-beta 1 consistently responded to liver and activation-regulated chemokine (LARC, also known as macrophage inflammatory protein-3 alpha).', select the correct biomedical concept corresponding to 'liver a... | <Options>: A: rantes (homo sapiens) (aka c-c motif chemokine ligand 5)
B: ccl16 (homo sapiens) (aka c-c motif chemokine ligand 16)
C: c-c motif chemokine ligand 27 (homo sapiens) (aka c-c motif chemokine ligand 27)
D: c-x-c motif chemokine ligand 3 (homo sapiens) (aka c-x-c motif chemokine ligand 3)
E: c-c motif chemok... | F |
<Instruct>: Given the context 'We observed that DCs generated from monocytes in the presence of GM-CSF, IL-4, and TGF-beta 1 consistently responded to liver and activation-regulated chemokine (LARC, also known as macrophage inflammatory protein-3 alpha).', select the correct biomedical concept corresponding to 'larc'. ... | <Options>: A: lncsrlr (homo sapiens) (aka lncrna sorafenib resistance in renal cell carcinoma associated)
B: larc (xenopus tropicalis) (aka c-c motif chemokine ligand 20)
C: larc (homo sapiens) (aka c-c motif chemokine ligand 20)
D: lncarsr (homo sapiens) (aka lncrna regulator of akt signaling associated with hcc and r... | C |
<Instruct>: Given the context 'We observed that DCs generated from monocytes in the presence of GM-CSF, IL-4, and TGF-beta 1 consistently responded to liver and activation-regulated chemokine (LARC, also known as macrophage inflammatory protein-3 alpha).', select the correct biomedical concept corresponding to 'macroph... | <Options>: A: c-x-c motif chemokine ligand 3 (homo sapiens) (aka c-x-c motif chemokine ligand 3)
B: mip-1-alpha (homo sapiens) (aka c-c motif chemokine ligand 3)
C: mcp-3 (homo sapiens) (aka c-c motif chemokine ligand 7)
D: mip-3 (homo sapiens) (aka c-c motif chemokine ligand 23)
E: mip-3a (homo sapiens) (aka c-c motif... | E |
<Instruct>: Given the context 'These immature DCs expressed one class of high-affinity binding sites for LARC, and expressed both CCR6 mRNA and protein.', select the correct biomedical concept corresponding to 'larc'. Answer using one of the provided options. | <Options>: A: lnc-rhl (homo sapiens) (aka lncrna regulator of hepatic lineages 1)
B: lar1 (homo sapiens) (aka la ribonucleoprotein 1, translational regulator)
C: larc (xenopus tropicalis) (aka c-c motif chemokine ligand 20)
D: lnccrla (homo sapiens) (aka myo1d divergent transcript)
E: larc (homo sapiens) (aka c-c motif... | E |
<Instruct>: Given the context 'These immature DCs expressed one class of high-affinity binding sites for LARC, and expressed both CCR6 mRNA and protein.', select the correct biomedical concept corresponding to 'ccr6'. Answer using one of the provided options. | <Options>: A: c-x-c motif chemokine receptor 6 (homo sapiens) (aka c-x-c motif chemokine receptor 6)
B: ccr-8 (homo sapiens) (aka c-c motif chemokine receptor 8)
C: ccr-6 (homo sapiens) (aka c-c motif chemokine receptor 6)
D: None of the above. | C |
<Instruct>: Given the context 'Therefore, LARC-CCR6 interaction presumably also contributes to the regulation of trafficking of monocyte-derived DCs, and utilization of TGF-beta can potentially provide a ready source of CCR6+ monocyte-derived DCs for therapeutic purposes.', select the correct biomedical concept corresp... | <Options>: A: lnc-rhl (homo sapiens) (aka lncrna regulator of hepatic lineages 1)
B: lar1 (homo sapiens) (aka la ribonucleoprotein 1, translational regulator)
C: lar (homo sapiens) (aka protein tyrosine phosphatase receptor type f)
D: lncsrlr (homo sapiens) (aka lncrna sorafenib resistance in renal cell carcinoma assoc... | E |
<Instruct>: Given the context 'Therefore, LARC-CCR6 interaction presumably also contributes to the regulation of trafficking of monocyte-derived DCs, and utilization of TGF-beta can potentially provide a ready source of CCR6+ monocyte-derived DCs for therapeutic purposes.', select the correct biomedical concept corresp... | <Options>: A: c-x-c motif chemokine receptor 6 (homo sapiens) (aka c-x-c motif chemokine receptor 6)
B: ccr-8 (homo sapiens) (aka c-c motif chemokine receptor 8)
C: ccr-6 (homo sapiens) (aka c-c motif chemokine receptor 6)
D: None of the above. | C |
<Instruct>: Given the context 'Therefore, LARC-CCR6 interaction presumably also contributes to the regulation of trafficking of monocyte-derived DCs, and utilization of TGF-beta can potentially provide a ready source of CCR6+ monocyte-derived DCs for therapeutic purposes.', select the correct biomedical concept corresp... | <Options>: A: cxcr6 (homo sapiens) (aka c-x-c motif chemokine receptor 6)
B: cc-ckr-8 (homo sapiens) (aka c-c motif chemokine receptor 8)
C: ccr-6 (homo sapiens) (aka c-c motif chemokine receptor 6)
D: None of the above. | C |
<Instruct>: Given the context 'Identification and characterization of PKNbeta, a novel isoform of protein kinase PKN: expression and arachidonic acid dependency are different from those of PKNalpha.
', select the correct biomedical concept corresponding to 'pknbeta'. Answer using one of the provided options. | <Options>: A: cdc42 binding protein kinase beta (bos taurus) (aka cdc42 binding protein kinase beta)
B: pkn-alpha (homo sapiens) (aka protein kinase n1)
C: pkgb (homo sapiens) (aka junction plakoglobin)
D: protein kinase c, beta (rattus norvegicus) (aka protein kinase c, beta)
E: pkbb (homo sapiens) (aka akt serine/thr... | F |
<Instruct>: Given the context 'Identification and characterization of PKNbeta, a novel isoform of protein kinase PKN: expression and arachidonic acid dependency are different from those of PKNalpha.
', select the correct biomedical concept corresponding to 'pknbeta'. Answer using one of the provided options. | <Options>: A: protein kinase c beta (bos taurus) (aka protein kinase c beta)
B: protein kinase c, beta (rattus norvegicus) (aka protein kinase c, beta)
C: cdc42 binding protein kinase beta (bos taurus) (aka cdc42 binding protein kinase beta)
D: pkc-beta (homo sapiens) (aka protein kinase c beta)
E: pkbbeta (homo sapien... | F |
<Instruct>: Given the context 'Identification and characterization of PKNbeta, a novel isoform of protein kinase PKN: expression and arachidonic acid dependency are different from those of PKNalpha.
', select the correct biomedical concept corresponding to 'pknalpha'. Answer using one of the provided options. | <Options>: A: prkn (homo sapiens) (aka parkin rbr e3 ubiquitin protein ligase)
B: pkn (drosophila melanogaster) (protein kinase n (drosophila melanogaster)) (aka protein kinase n)
C: pkn-alpha (homo sapiens) (aka protein kinase n1)
D: pkn-alpha (xenopus tropicalis) (aka protein kinase n1)
E: pku-alpha (homo sapiens) (a... | C |
<Instruct>: Given the context 'The cDNA clone encoding a novel isoform of protein kinase PKN, termed PKNbeta, was isolated from a HeLa cDNA library.', select the correct biomedical concept corresponding to 'pknbeta'. Answer using one of the provided options. | <Options>: A: cdc42 binding protein kinase beta (bos taurus) (aka cdc42 binding protein kinase beta)
B: prkcb (homo sapiens) (aka protein kinase c beta)
C: pkbb (homo sapiens) (aka akt serine/threonine kinase 2)
D: protein kinase c, beta (rattus norvegicus) (aka protein kinase c, beta)
E: pkgb (homo sapiens) (aka junct... | F |
<Instruct>: Given the context 'PKNbeta had high sequence homology with PKNalpha, originally isolated PKN, especially in the repeats of charged amino acid-rich region with leucine-zipper like sequences (CZ region/HR1), in the carboxyl-terminal catalytic domain, and in approximately 130 amino acid stretch (D region/HR2),... | <Options>: A: protein kinase c beta (bos taurus) (aka protein kinase c beta)
B: pkn-alpha (homo sapiens) (aka protein kinase n1)
C: pkbb (homo sapiens) (aka akt serine/threonine kinase 2)
D: protein kinase c, beta (rattus norvegicus) (aka protein kinase c, beta)
E: pkgb (homo sapiens) (aka junction plakoglobin)
F: None... | F |
<Instruct>: Given the context 'PKNbeta had high sequence homology with PKNalpha, originally isolated PKN, especially in the repeats of charged amino acid-rich region with leucine-zipper like sequences (CZ region/HR1), in the carboxyl-terminal catalytic domain, and in approximately 130 amino acid stretch (D region/HR2),... | <Options>: A: pkn-alpha (homo sapiens) (aka protein kinase n1)
B: prkr (homo sapiens) (aka eukaryotic translation initiation factor 2 alpha kinase 2)
C: pku-alpha (homo sapiens) (aka tousled like kinase 2)
D: pkn (drosophila melanogaster) (protein kinase n (drosophila melanogaster)) (aka protein kinase n)
E: pkn-alpha ... | A |
<Instruct>: Given the context 'However, the amino acid sequence of PKNbeta differed from that of PKNalpha in the region immediately amino-terminal to the catalytic domain, which contained two distinct proline-rich sequences consistent with the class II consensus sequence, PXXPXR, for binding to SH3 domain.', select the... | <Options>: A: protein kinase c beta (homo sapiens) (aka protein kinase c beta)
B: protein kinase c beta (bos taurus) (aka protein kinase c beta)
C: pkn-alpha (homo sapiens) (aka protein kinase n1)
D: pkgb (homo sapiens) (aka junction plakoglobin)
E: cdc42 binding protein kinase beta (bos taurus) (aka cdc42 binding prot... | F |
<Instruct>: Given the context 'However, the amino acid sequence of PKNbeta differed from that of PKNalpha in the region immediately amino-terminal to the catalytic domain, which contained two distinct proline-rich sequences consistent with the class II consensus sequence, PXXPXR, for binding to SH3 domain.', select the... | <Options>: A: prkn (homo sapiens) (aka parkin rbr e3 ubiquitin protein ligase)
B: pkn-alpha (xenopus tropicalis) (aka protein kinase n1)
C: pkn1 (homo sapiens) (aka protein kinase n1)
D: pku-alpha (homo sapiens) (aka tousled like kinase 2)
E: pkn-alpha (xenopus laevis) (aka protein kinase n1 l homeolog)
F: None of the ... | C |
<Instruct>: Given the context 'Distribution of PKNbeta differed from that of PKNalpha in the following two respects: (1) Northern blotting indicated that PKNbeta mRNA could not be detected in human adult tissues, but was expressed abundantly in human cancer cell lines; (2) immunochemical analysis indicated that PKNbeta... | <Options>: A: prkcb (homo sapiens) (aka protein kinase c beta)
B: protein kinase c, beta (rattus norvegicus) (aka protein kinase c, beta)
C: pkn-alpha (homo sapiens) (aka protein kinase n1)
D: protein kinase c beta (bos taurus) (aka protein kinase c beta)
E: cdc42 binding protein kinase beta (bos taurus) (aka cdc42 bin... | F |
<Instruct>: Given the context 'Distribution of PKNbeta differed from that of PKNalpha in the following two respects: (1) Northern blotting indicated that PKNbeta mRNA could not be detected in human adult tissues, but was expressed abundantly in human cancer cell lines; (2) immunochemical analysis indicated that PKNbeta... | <Options>: A: pkn-alpha (xenopus tropicalis) (aka protein kinase n1)
B: pku-alpha (homo sapiens) (aka tousled like kinase 2)
C: pkn2 (homo sapiens) (aka protein kinase n2)
D: prkr (homo sapiens) (aka eukaryotic translation initiation factor 2 alpha kinase 2)
E: pkn (homo sapiens) (aka protein kinase n1)
F: None of the ... | E |
<Instruct>: Given the context 'Distribution of PKNbeta differed from that of PKNalpha in the following two respects: (1) Northern blotting indicated that PKNbeta mRNA could not be detected in human adult tissues, but was expressed abundantly in human cancer cell lines; (2) immunochemical analysis indicated that PKNbeta... | <Options>: A: pkbb (homo sapiens) (aka akt serine/threonine kinase 2)
B: protein kinase c beta (bos taurus) (aka protein kinase c beta)
C: pkc-beta (homo sapiens) (aka protein kinase c beta)
D: pkn-alpha (homo sapiens) (aka protein kinase n1)
E: cdc42 binding protein kinase beta (bos taurus) (aka cdc42 binding protein ... | F |
<Instruct>: Given the context 'Distribution of PKNbeta differed from that of PKNalpha in the following two respects: (1) Northern blotting indicated that PKNbeta mRNA could not be detected in human adult tissues, but was expressed abundantly in human cancer cell lines; (2) immunochemical analysis indicated that PKNbeta... | <Options>: A: protein kinase c beta (bos taurus) (aka protein kinase c beta)
B: pkn-alpha (homo sapiens) (aka protein kinase n1)
C: cdc42 binding protein kinase beta (bos taurus) (aka cdc42 binding protein kinase beta)
D: pkbb (homo sapiens) (aka akt serine/threonine kinase 2)
E: protein kinase c, beta (rattus norvegic... | F |
<Instruct>: Given the context 'Distribution of PKNbeta differed from that of PKNalpha in the following two respects: (1) Northern blotting indicated that PKNbeta mRNA could not be detected in human adult tissues, but was expressed abundantly in human cancer cell lines; (2) immunochemical analysis indicated that PKNbeta... | <Options>: A: protein kinase c beta (homo sapiens) (aka protein kinase c beta)
B: pkgb (homo sapiens) (aka junction plakoglobin)
C: pkn-alpha (homo sapiens) (aka protein kinase n1)
D: protein kinase c, beta (rattus norvegicus) (aka protein kinase c, beta)
E: cdc42 binding protein kinase beta (bos taurus) (aka cdc42 bin... | F |
<Instruct>: Given the context 'Recombinant PKNbeta expressed in COS7 cells displayed autophosphorylation and peptide kinase activity, but was found to be significantly less responsive to arachidonic acid than PKNalpha.', select the correct biomedical concept corresponding to 'pknbeta'. Answer using one of the provided ... | <Options>: A: pkc-beta (homo sapiens) (aka protein kinase c beta)
B: pkgb (homo sapiens) (aka junction plakoglobin)
C: protein kinase c, beta (rattus norvegicus) (aka protein kinase c, beta)
D: protein kinase c beta (bos taurus) (aka protein kinase c beta)
E: pkbbeta (homo sapiens) (aka akt serine/threonine kinase 2)
F... | F |
<Instruct>: Given the context 'Recombinant PKNbeta expressed in COS7 cells displayed autophosphorylation and peptide kinase activity, but was found to be significantly less responsive to arachidonic acid than PKNalpha.', select the correct biomedical concept corresponding to 'pknalpha'. Answer using one of the provided... | <Options>: A: pku-alpha (homo sapiens) (aka tousled like kinase 2)
B: pkn (drosophila melanogaster) (protein kinase n (drosophila melanogaster)) (aka protein kinase n)
C: pkn-alpha (homo sapiens) (aka protein kinase n1)
D: pkn-alpha (xenopus tropicalis) (aka protein kinase n1)
E: prkr (homo sapiens) (aka eukaryotic tra... | C |
<Instruct>: Given the context 'Coats' disease of the retina (unilateral retinal telangiectasis) caused by somatic mutation in the NDP gene: a role for norrin in retinal angiogenesis.
', select the correct biomedical concept corresponding to 'ndp'. Answer using one of the provided options. | <Options>: A: norrin cystine knot growth factor ndp (homo sapiens) (aka norrin cystine knot growth factor ndp)
B: ndc1 transmembrane nucleoporin (homo sapiens) (aka ndc1 transmembrane nucleoporin)
C: ndn (homo sapiens) (aka necdin, mage family member)
D: ndp (xenopus tropicalis) (aka norrin cystine knot growth factor n... | A |
<Instruct>: Given the context 'Coats' disease of the retina (unilateral retinal telangiectasis) caused by somatic mutation in the NDP gene: a role for norrin in retinal angiogenesis.
', select the correct biomedical concept corresponding to 'norrin'. Answer using one of the provided options. | <Options>: A: norrin cystine knot growth factor ndp (rattus norvegicus) (aka norrin cystine knot growth factor ndp)
B: norrin cystine knot growth factor ndp (homo sapiens) (aka norrin cystine knot growth factor ndp)
C: connectin (rattus norvegicus) (aka titin)
D: nrn (rattus norvegicus) (aka neuritin 1)
E: norbin (ratt... | B |
<Instruct>: Given the context 'Both carried a missense mutation within the NDP gene on chromosome Xp11.2.', select the correct biomedical concept corresponding to 'ndp'. Answer using one of the provided options. | <Options>: A: ndnf (homo sapiens) (aka neuron derived neurotrophic factor)
B: ndpp (homo sapiens) (aka caspase recruitment domain family member 8)
C: ndc1 transmembrane nucleoporin (homo sapiens) (aka ndc1 transmembrane nucleoporin)
D: ndp (rattus norvegicus) (aka norrin cystine knot growth factor ndp)
E: ndp (homo sap... | E |
<Instruct>: Given the context 'Subsequently analysis of the retinas of nine enucleated eyes from males with Coats' disease demonstrated in one a somatic mutation in the NDP gene which was not present within non-retinal tissue.', select the correct biomedical concept corresponding to 'ndp'. Answer using one of the provi... | <Options>: A: ndp (rattus norvegicus) (aka norrin cystine knot growth factor ndp)
B: norrin cystine knot growth factor ndp (homo sapiens) (aka norrin cystine knot growth factor ndp)
C: ndnf (homo sapiens) (aka neuron derived neurotrophic factor)
D: ndpkd (homo sapiens) (aka nme/nm23 nucleoside diphosphate kinase 4)
E: ... | B |
<Instruct>: Given the context 'We suggest that Coats' telangiectasis is secondary to somatic mutation in the NDP gene which results in a deficiency of norrin (the protein product of the NDP gene) within the developing retina.', select the correct biomedical concept corresponding to 'ndp'. Answer using one of the provid... | <Options>: A: ndp (xenopus tropicalis) (aka norrin cystine knot growth factor ndp)
B: ndn (homo sapiens) (aka necdin, mage family member)
C: norrin cystine knot growth factor ndp (homo sapiens) (aka norrin cystine knot growth factor ndp)
D: ndpkd (homo sapiens) (aka nme/nm23 nucleoside diphosphate kinase 4)
E: ndnf (ho... | C |
<Instruct>: Given the context 'We suggest that Coats' telangiectasis is secondary to somatic mutation in the NDP gene which results in a deficiency of norrin (the protein product of the NDP gene) within the developing retina.', select the correct biomedical concept corresponding to 'norrin'. Answer using one of the pro... | <Options>: A: nynrin (rattus norvegicus) (aka nyn domain and retroviral integrase containing)
B: norp (rattus norvegicus) (aka nucleolin, pseudogene 1)
C: norrin cystine knot growth factor ndp (rattus norvegicus) (aka norrin cystine knot growth factor ndp)
D: neuritin 1-like (rattus norvegicus) (aka neuritin 1-like)
E:... | E |
<Instruct>: Given the context 'We suggest that Coats' telangiectasis is secondary to somatic mutation in the NDP gene which results in a deficiency of norrin (the protein product of the NDP gene) within the developing retina.', select the correct biomedical concept corresponding to 'ndp'. Answer using one of the provid... | <Options>: A: ndp (rattus norvegicus) (aka norrin cystine knot growth factor ndp)
B: ndnf (homo sapiens) (aka neuron derived neurotrophic factor)
C: ndc1 transmembrane nucleoporin (homo sapiens) (aka ndc1 transmembrane nucleoporin)
D: norrin cystine knot growth factor ndp (homo sapiens) (aka norrin cystine knot growth ... | D |
<Instruct>: Given the context 'A common polymorphic allele of the human luteinizing hormone beta-subunit gene: additional mutations and differential function of the promoter sequence.
', select the correct biomedical concept corresponding to 'luteinizing hormone beta-subunit'. Answer using one of the provided options. | <Options>: A: lutropin subunit beta (bos taurus) (aka lutropin subunit beta)
B: lhb (homo sapiens) (chorionic gonadotropin subunit beta 3 (homo sapiens)) (aka chorionic gonadotropin subunit beta 3)
C: thyroid stimulating hormone subunit beta (homo sapiens) (aka thyroid stimulating hormone subunit beta)
D: luteinizing h... | E |
<Instruct>: Given the context 'A common polymorphic allele of the human luteinizing hormone beta-subunit gene: additional mutations and differential function of the promoter sequence.
', select the correct biomedical concept corresponding to 'luteinizing hormone beta-subunit'. Answer using one of the provided options. | <Options>: A: follicle stimulating hormone subunit beta (homo sapiens) (aka follicle stimulating hormone subunit beta)
B: chorionic gonadotropin subunit beta 1 (homo sapiens) (aka chorionic gonadotropin subunit beta 1)
C: lutropin subunit beta (bos taurus) (aka lutropin subunit beta)
D: thyroid stimulating hormone subu... | F |
<Instruct>: Given the context 'A common genetic variant (V) of the human luteinizing hormone (LH) beta-subunit gene was recently discovered.', select the correct biomedical concept corresponding to 'luteinizing hormone (lh) beta-subunit'. Answer using one of the provided options. | <Options>: A: lutropin subunit beta (bos taurus) (aka lutropin subunit beta)
B: luteinizing hormone subunit beta (bos taurus) (aka luteinizing hormone subunit beta)
C: lhb (homo sapiens) (chorionic gonadotropin subunit beta 3 (homo sapiens)) (aka chorionic gonadotropin subunit beta 3)
D: thyroid stimulating hormone sub... | E |
<Instruct>: Given the context 'The V-LH molecules have higher bioactivity in vitro, but shorter half-life in circulation, which apparently is related to the alterations of LH function observed in individuals homo- and heterozygous for the V-LHbeta allele.', select the correct biomedical concept corresponding to 'lhbeta... | <Options>: A: luteinizing hormone subunit beta (bos taurus) (aka luteinizing hormone subunit beta)
B: luteinizing hormone subunit beta (sus scrofa) (aka luteinizing hormone subunit beta)
C: lsh-beta (homo sapiens) (aka luteinizing hormone subunit beta)
D: lutropin subunit beta (bos taurus) (aka lutropin subunit beta)
E... | C |
<Instruct>: Given the context 'We have now studied whether additional mutations in the V-LHbeta promoter sequence could contribute to the altered physiology of the LH variant molecules.', select the correct biomedical concept corresponding to 'lhbeta'. Answer using one of the provided options. | <Options>: A: luteinizing hormone subunit beta (bos taurus) (aka luteinizing hormone subunit beta)
B: luteinizing hormone subunit beta (sus scrofa) (aka luteinizing hormone subunit beta)
C: luteinizing hormone subunit beta (homo sapiens) (aka luteinizing hormone subunit beta)
D: luteinizing hormone subunit beta (xenopu... | C |
<Instruct>: Given the context 'The 661 bp 5'-flanking region of the V-LHbeta gene, retrieved from human genomic DNA by PCR, contained eight single-nucleotide changes, as compared with the wild-type (wt) LHbeta promoter.', select the correct biomedical concept corresponding to 'lhbeta'. Answer using one of the provided ... | <Options>: A: luteinizing hormone subunit beta (homo sapiens) (aka luteinizing hormone subunit beta)
B: lutropin subunit beta (bos taurus) (aka lutropin subunit beta)
C: lutropin subunit beta-like (xenopus laevis) (aka lutropin subunit beta-like)
D: luteinizing hormone subunit beta (oryctolagus cuniculus) (aka luteiniz... | A |
<Instruct>: Given the context 'The 661 bp 5'-flanking region of the V-LHbeta gene, retrieved from human genomic DNA by PCR, contained eight single-nucleotide changes, as compared with the wild-type (wt) LHbeta promoter.', select the correct biomedical concept corresponding to 'lhbeta'. Answer using one of the provided ... | <Options>: A: lutropin subunit beta (bos taurus) (aka lutropin subunit beta)
B: luteinizing hormone subunit beta (bos taurus) (aka luteinizing hormone subunit beta)
C: luteinizing hormone subunit beta (oryctolagus cuniculus) (aka luteinizing hormone subunit beta)
D: lhb (homo sapiens) (luteinizing hormone subunit beta ... | D |
<Instruct>: Given the context 'Reporter constructs with various lengths of the wt- and V-LH promoter sequences, driving the firefly luciferase reporter gene, were transfected into an immortalized mouse pituitary cell line, LbetaT(2), known to express the endogenous LHbeta gene, and into a non-endocrine human embryonic ... | <Options>: A: lutropin subunit beta-like (xenopus laevis) (aka lutropin subunit beta-like)
B: lutropin subunit beta-like (xenopus tropicalis) (aka lutropin subunit beta-like)
C: lhb (homo sapiens) (luteinizing hormone subunit beta (homo sapiens)) (aka luteinizing hormone subunit beta)
D: luteinizing hormone subunit bet... | C |
<Instruct>: Given the context 'Basal expression levels of the V-LHbeta promoter constructs were on average 36% higher in LbetaT(2)cells ( P < 0.001; n = 29), and 40% higher in HEK 293 cells ( P < 0.001; n = 16), as compared with the respective wt sequences.', select the correct biomedical concept corresponding to 'lhbe... | <Options>: A: lutropin subunit beta-like (xenopus laevis) (aka lutropin subunit beta-like)
B: lsh-beta (homo sapiens) (aka luteinizing hormone subunit beta)
C: luteinizing hormone subunit beta (oryctolagus cuniculus) (aka luteinizing hormone subunit beta)
D: lutropin subunit beta-like (xenopus tropicalis) (aka lutropin... | B |
<Instruct>: Given the context 'Numerous qualitative and quantitative differences were found between the two cell lines in responses of the two promoter sequences to stimulation with 12- O -tetradecanoylphorbol-13-acetate, forskolin, 8-bromo-cAMP, progesterone and gonado- tropin-releasing hormone.', select the correct b... | <Options>: A: hypocretin (orexin) neuropeptide precursor (xenopus tropicalis) (aka hypocretin (orexin) neuropeptide precursor)
B: growth hormone releasing hormone (xenopus tropicalis) (aka growth hormone releasing hormone)
C: growth hormone releasing hormone (rattus norvegicus) (aka growth hormone releasing hormone)
D:... | E |
<Instruct>: Given the context 'In conclusion, the V-LHbeta promoter has higher basal activity, and differs in response to hormonal stimulation, as compared with the wt-LHbeta promoter.', select the correct biomedical concept corresponding to 'lhbeta'. Answer using one of the provided options. | <Options>: A: luteinizing hormone subunit beta (xenopus tropicalis) (aka luteinizing hormone subunit beta)
B: luteinizing hormone subunit beta (sus scrofa) (aka luteinizing hormone subunit beta)
C: luteinizing hormone subunit beta (bos taurus) (aka luteinizing hormone subunit beta)
D: luteinizing hormone subunit beta (... | E |
<Instruct>: Given the context 'In conclusion, the V-LHbeta promoter has higher basal activity, and differs in response to hormonal stimulation, as compared with the wt-LHbeta promoter.', select the correct biomedical concept corresponding to 'lhbeta'. Answer using one of the provided options. | <Options>: A: lsh-beta (homo sapiens) (aka luteinizing hormone subunit beta)
B: luteinizing hormone subunit beta (sus scrofa) (aka luteinizing hormone subunit beta)
C: luteinizing hormone subunit beta (oryctolagus cuniculus) (aka luteinizing hormone subunit beta)
D: luteinizing hormone subunit beta (bos taurus) (aka lu... | A |
<Instruct>: Given the context 'In conclusion, the V-LHbeta promoter has higher basal activity, and differs in response to hormonal stimulation, as compared with the wt-LHbeta promoter.', select the correct biomedical concept corresponding to 'lhbeta'. Answer using one of the provided options. | <Options>: A: luteinizing hormone subunit beta (xenopus tropicalis) (aka luteinizing hormone subunit beta)
B: luteinizing hormone subunit beta (oryctolagus cuniculus) (aka luteinizing hormone subunit beta)
C: luteinizing hormone subunit beta (bos taurus) (aka luteinizing hormone subunit beta)
D: lutropin subunit beta (... | F |
<Instruct>: Given the context 'The altered promoter function of the V-LHbeta gene provides evidence for differences in regulation of the wt- and V-LHbeta genes, which may contribute to the differences observed in pituitary-gonadal function between carriers of the two LHbeta alleles.', select the correct biomedical conc... | <Options>: A: lutropin subunit beta (bos taurus) (aka lutropin subunit beta)
B: luteinizing hormone subunit beta (sus scrofa) (aka luteinizing hormone subunit beta)
C: luteinizing hormone subunit beta (bos taurus) (aka luteinizing hormone subunit beta)
D: lsh-beta (homo sapiens) (aka luteinizing hormone subunit beta)
E... | D |
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