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Senior Scientist , Computational Chemistry . . Computational Chemist with a strong foundation in hard science and 8 years of experience in theoretical and computational modeling . Leverage deep learning and reinforcement learning approaches to advance drug discovery and development . Demonstrated expertise in computational modeling with 1 patent , 15 papers and 1 book chapter , serving as a first author for 10 of them from MS and PhD work . Ability to implement algorithms and proficient in Python . Equipped with 3 years of experience in writing patent applications and office actions . Selected Highlights : Provided computational chemistry support to COVID 19 drug development . Implement deep learning and reinforcement learning approaches for in house use . Developed a drug design software in Java which was patented in Taiwan Patent No . I611053 . Developed physical models that improved simulation accuracy and have been used world wide in simulation programs such as CHARMM , NAMD , GROMACS , and OpenMM . Developed data mining algorithms to retrieve complex geometric data of 145 K macromolecules and revealed new insights . Selected Machine Learning Projects conducted in 2019 : Built a convolutional neural network to automatically identify images between different bee species . Utilized ensemble method and hyperparameter tuning to predict Airbnb listing prices along with feature importances . Built a content based recommender using NLP and provided its interactive data visualization using t SNE algorithm . . Technologies :

Head of Research Informatics . . . Technologies :

Senior Scientist II , Computational Biology and Bioinformatics . . Experienced Research Scientist with a demonstrated history of working in the biotechnology industry . Skilled in DNA Sequencing , Cancer Research , Life Sciences , R , and Genomics . Strong research professional with a Doctor of Philosophy Ph.D. focused in Bioinformatics from Boston University . . Technologies :

Scientific Director Research Informatics DPO . Key driver of integrating Nuevolution as a Center of Excellence in Amgen research Managing Research Informatics at ARC and advocating research informatics globally Pushing DNA Encoded Library technology through augmentation of AI , Machine learning and virtual screening technologies Developing new application areas of the DEL technology . PhD in Molecular Biology with focus on cross disciplinary research spanning from classical genetics to protein structure modeling . Joined Novo Nordisk Novozymes to work on protein engineering , manager of major R D project and active in identifying new business applications . Co founder of Nuevolution , inventor and leader within DNA encoded library technology Chemetics aka DEL . Worked with my excellent colleagues to develop and mature the technology from an idea to a powerful drug discovery engine with an impressive track record of delivering new drug candidates to big pharma partners and an internal pipeline . After being acqusitioned by Amgen July 2019 , I ve been a key driver in the integration of Nuevolution into Amgen Research . I ve been responsible of project scouting and evaluation ; Drug target identification within inflammation , oncology and immunoncology ; Development of new business opportunities for the application of Chemetics ; Competitive intelligence ; Alliance project management of drug discovery collaborations ; Research Informatics Bioinformatics and cheminformatics ; IT management ; Security and compliance management ; Data Protection . Versatility is my trademark ; I span across disciplines identifying the gaps of challenge and opportunitties arising in intersections between technologies , driving new advances and innovation enabling development of new medicines . Current focus is driving forward Amgen research informatics embracing areas big data analytics , machine learning and pushing innovative uses of the DEL platform for new therapeutics .. Technologies :

Research Assistant Professor of Pharmacology . Structural neurobiology and molecular pharmacology of ion channels . A research faculty with expertise in structural biology of membrane proteins aiming to improve future medicines through biomedical research and drug development .. Technologies :

membrane proteins;structure

Principal Scientist , Therapeutic Modalities Small Molecules Research Lead Discovery . Drug Discovery . Lead discovery program leader . Small Molecule Research . Screening , Profiling . Mechanistic cellular assays . Skilled scientist with 12 years of hands on lab experience , 5 in industry . Dedicated to personalized therapies , molecular medicine , gene and cell therapy . Broad interest in science , demonstrated success in diverse fields of research . Proven mentoring , teaching and team leadership abilities . . Effective and personable communicator . As a problem solver I enjoy finding creative solutions to challenging situations . My interest focuses on nucleic acid therapeutics that includes exploiting RNA DNA molecules both as drugs and targets , gene and cell therapy . I am passionate about technology assay development and studies on drugs MOA . I am an experienced molecular and cellular biologist with good knowledge of biochemistry . . Trained as RNA biologist , I extensively studied RNA processing and its dysregulation in disease , in particular in neurodegeneration . In industrial settings , I dealt with diverse therapeutic modalities , including small molecule inhibitors , engineered antibodies and mRNA based vaccines in the context of cancer immunology . . I value diversity , collaboration and the possibility to work in a cross functional environment . This led me to establish numerous alliances and productive interdisciplinary partnerships . I feel fortunate to have had the possibility to mentor several students and to lead a cross functional team for a technology development effort . . I am currently part of the Lead Discovery Team in Roche focusing on Small Molecule Therapeutics . . Technologies :

antibodies;biologics;nucleic acids;small molecules;engineering;screening

Doctoral Researcher . . I am a computational ecologist with broad interests throughout the natural world . My current research focuses on spider web morphology and scaling relationships throughout the arachnid world . Furthermore as a previous graphic design student and current musician i am fascinated by bioacoustics and sensory processing throughout nature . From thermal imaging of social insects and nematode worm bioacoustics through to computational modelling of spider web scaling , in the lab and the field , innovative research at the cutting edge of technology and knowledge is always my aim .. Technologies :

Production Scientist . 1 Enzymes Monoclonal Antibodies purification in regulated environment following GDP Good Documentation Practices . 1.1 Development of Chromatographic Strategies for purification of biomolecules . 1.2 Handling and Mantenance of Chromatography columns . 1.3 Optimization Scaling up 1 g to 100 g final purified product . 2 Expertise with kta avant pilot process . 2.1 Automation development of totally automated or hybrid automated manual control methods to achieve faster and consistent chromatographic separations . 3 Technical drawing of highly detailed schemes describing how to handle complex equipment and describing processes . . Currently works at Bioline GmbH as Production Scientist . Mastered skills : 1 Chromatography , strong with kta Purifier , Avant and Pilot 2 Cloning , protein engineering , production purification , . Technologies :

antibodies;proteins;expression

Senior Scientist . . Senior Scientist at Orthros Medical , a scale up biotech developing and manufacturing engineered antibody fragments , VHH , in yeast . With scientific experience developed through my PhD background in pathogenic Candida spp . and post doctoral studies in yeast biology and clinical diagnostics , I am now working on VHH optimization and manufacturing in yeast . As a senior scientist I am overseeing development strategy and process optimization as well as project management and laboratory execution . In addition , I am acting as an R D point of contact for our customers . . Technologies :

antibodies;engineering

Assistant Professor . . Membrane proteins represent intriguing objects for investigation , though they remained a terra incognita of the structural biology for many decades . Novel methods , such as atomic force microscopy and high resolution fluorescence microscopy allow for spectacular insights on these systems . I am interested in studying diverse dynamic biological interactions down to single molecule level , with a primary focus on membrane protein systems . Specialties : Theoretical and practical background in protein research Broad expertise in research methods Team supervision and support . Technologies :

membrane proteins;structure

Scientist . Research Discovery , PCO Drug Metabolism and Pharmacokinetics Working in a collaborative environment with biologists , medicinal chemists , and DMPK scientists , to support small molecule drug discovery programs in the areas of oncology , inflammation , immunology , fibrosis , and neglected diseases . Provide extensive knowledge of ADME properties and applications to projects by assisting with discovery project representation , study coordination , ADME data interpretation and presentation of scientific findings Contributing to experiment design and resolving project barriers with collaboration with pharmacology and toxicology departments Generating and executing protocols and technical reports with precision Aiding management on improving efficiency and productivity within the group by training junior associates , and developing assays . . Technologies :

Scientist II . . I am a research Scientist with over 10nyears of experience in the field of structural biology and drug development . In addition , I have over ten years of experience in molecular biology and recombinant DNA work , assay development , cell biology and biochemistry techniques and in depth knowledge and skills in protein expression and purification , Protein crystallography and other biophysical techniques . I received my Ph.D. in Structural Biology from the Jawaharlal Nehru University , India and then went on to do postdoctoral studies at Washington University in St. Louis School of Medicine in the biochemistry department . Expertise : Protein Expression bacterial , insect and mammalian cell Molecular Biology Protein Engineering Protein purification Biochemical and Biophysical Characterization of Proteins Protein conjugation with Fluorescence probe including , Amine coupling , maleimide and sortase reaction Protein protein , Protein DNA and protein small molecule interaction Bioinformatics , Docking and Protein Engineering Protein Crystallization and X ray Crystallography Small angle X ray scattering Core competencies : Cell culture bacterial , insect and mammalian PCR , DNA cloning , site directed mutagenesis FPLC Biorad NGC , HPLC Dionex , AKTA , affinity , ion exchange and size exclusion chromatography Antibody purification Mass spec LC MS , GEE labelling footprinting and LC MS MS , SPR , ITC , Thermal melt assay , radioligand binding , HTS Crystallization , structure solution using Molecular replacement and SAD methods UV visible , Circular dichroism and fluorescence spectroscopy Bioinformatics approach for protein engineering Cell based assays Liposome preparation FRET and fluorescence based High throughput assay development R programming , Python programming , Tableau for data visualization and analysis . Technologies : Xray;CryoEM;ITC;SPR;AUC;CD;FRET

proteins;characterization;expression;interaction;structure

Scientist , Statistical Genetics . . . Technologies :

Research Intern . Department of Actives and Formulations Protein Stability . I am a honest , hardworking and ambitious student who aspires to be a Scientist in the field of Bio pharmaceuticals . My objective is to be associated with an institution that gives me a platform to enhance my knowledge and skills in accordance with the recent trends in the field of research and development . I wish to provide help and service to the people with the knowledge and experience I have and would gain in my academic career . . Technologies :

proteins;stability

Senior Research Fellow . . Computational Chemistry and Biophysics . Technologies :

Adjunct Professor . I teach a variety of courses primarily involving Data Science to undergraduate students . . Computational Neuroscientist focusing on designing and developing applications that utilize affective inputs such as emotions , pupillometry , for neuropsychological investigations , HCI , BCI , Robotics , Recommender Systems , and novel Biometric solutions . I have 20 years in this domain , as an academic and as a developer utilizing state of the art machine learning algorithms reinforcement learning , deep learning , recurrent NN , rule based systems such as rough sets and fuzzy sets , I have published over 170 scientific papers and 3 books on a variety of topics ranging from basic data classification techniques to deploying real world neuropsychological applications for the sentiment analysis , locked In subjects BCI , and user specific biometric person identification solutions . I also have a significant amount of AI machine learning experience spanning more than 30 years . I have utilized neural networks , GAs , L Systems , AIS , swarm technologies , as well as more traditional machine learning algorithms , such as LVQ , Tree based methods , clustering , gene sequencing strategies , computer vision analysis of medical imaging datasets , amongst a host of other technologies . More recently , I have focused on deep learning within the document imaging domain , focusing on mortgage documents 4 years .. Technologies :

Senior Scientist at BioMedicine Design Pfizer . Bio therapeutic discovery . o Antibody engineering . . o Use of display technologies , phage and yeast , for selection campaigns . o Flow cytometry and single cell sorting . . o Development and optimization of selection methods . o Analysis of antibody properties using polyreactivity assay , aSEC , SDS PAGE , ELISA . . o Expression and purification of antibodies . o Molecular biology , cloning , and vector engineering and design . . . Technologies :

antibodies;characterization;engineering;expression

Associate Principal Scientist Discovery Sciences Medicinal Chemist . . . Technologies :

Researcher . GC MS , LC MS MS , ICP OES , XRF . . Analytical chemist , neurochemist , biochemist , electrochemist . Working at Swerea IVF . Postdoc in marine chemical ecology . Isolation and determination of lipid structures of new , unknown signal substances from copepods with LCMS , GCMS and NMR . Doctoral thesis work included method development of separation , electrochemical detection and analysis of neurotransmitters . Also focused on pharmacological aspects of drugs associated with neurotransmitter protein transporters . Used the in vivo model Drosophila melanogaster . Master of science thesis work included protein purification , crystallisation and catalytic activity assay of membrane proteins .. Technologies : NMR

membrane proteins;stability

Researcher . Analysis of deep mutational scanning data beta lactamase using variational autoencoder Writing original research manuscript providing new insights into the evolution of multidrug resistance in bacteria Writing in collaboration : method for microbial GWAS using Probabilistic Soft Logic Supervision of team developing microbial GWAS methods for detection of epistatic interactions Supervision of team detecting mutation signatures in HIV using a technique for blind source separation . Inspired computational evolutionary biologist with a track record of success on high profile projects and with extensive experience in bioinformatics algorithm development and statistical analysis of large genomics data . Also enjoys teaching , mentoring , recruiting and supervising talent .. Technologies :

Scientific Researcher . Developing in silico methods for drug repurposing Writing grant proposals Coordinating WP1 in silico trial prediction and WP2 pre clinical validation of predictions collaboration REPO TRIAL H2020 project . . Technologies :

small molecules;developing

Principal Scientist . Downstream Process Development . KEY ACHIEVEMENTS Established the strategy towards phase III and registration for virus clearance , including process challenge of virus clearance . The strategy was endorsed by several authorities , among others Paul Ehrlich Institute and FDA Established the strategy for Process Challenge of the Purification Process for a late stage product . The strategy was endorsed by the authorities menthioned above . Development of a process for preparation of material for a generic HCP assay , valid for registration . The prepared material obtained a high coverage of HCP in the unprocessed harvest . Significant contribution to the development of existing mAb platforms with respect to virus clearance Development and implementation of a microfiltration step for harvest . Responsible for experiments from lab scale via pilot scale to production scale . Work presented at GE life science day 2010 and implemented in the final process for market . Considerable improvement of the FVII a process in production by experiments concerning the mechanisms involved in steering the activation degradation of FVII a in solution and during the chromatographic process . Validation of UV treatment of serum in order to clear potential virus . Significant contribution to a major upgrade of LIMS in the QC laboratory , including automatic calculation of results . Technologies :

Senior Scientist , Data Science . . Computational Biologist Data Scientist : 12 6 years industry 6 years academia years experience as data science lead on multi disciplinary project teams within and without the organization ; Designed 100 in vitro , 40 pre clinical experiments and 3 clinical studies ; screening , lead prioritization , exploration of MoA and lead optimization . Created multiple innovative computational statistical solutions for leveraging high dimensional multivariate and univariate datasets generated within and without the organization that led to more efficient screening , lead identification and generation of value for the company . Encouraged and educated non statistically trained colleagues in the research organization to think statistically while planning studies experiments and communicate complex multivariate datasets more effectively . Relevant technical skills Bioinformatics and statistical analysis of mutivariate omics data analysis : Compositional data 16s , shallow and deep shotgun sequencing based taxonomy and functional data ; RNASeq based metatranscriptomics , transcriptomics datasets , Affymetrix chips based gene expression datasets ; Metabolomics untargeted metabolomics of clinical samples , GC MS , LC MS targeted metabolites like short chain fatty acids and bile acids from clinical and ex vivo samples ; Immunoprofiling Luminex panel , dentritic cell profiling and TEER data from ex vivo samples ; Colorimetric assay data primary bile acids , ammonia , trimethylamine tma and optical density od600 data Next generation sequencing data NGS analysis taxonomy , functional genomics , transcriptomics , metatranscriptomics datasets metaphlan2 , humann2 , SAMtools , BURST , DIAMOND , Bowtie , Tophat ; downstream analysis Cufflinks , DESeq , EdgeR , Newbler etc . Processing of 2D NMR and permethylation linkage analysis data for structural profiling . Gitlab version controlled development and modification of machine learning methods algorithms . Data visualization and sharing using the R platform ggplot , R markdown , plotly , R shiny , Igraph , tableau , visualizing and analyzing complex biological networks using JUNG and Cytoscape platforms of Java . AWS services aws cli , EC2 linux AMIs , Nexflow workflows Design , analysis and implementation of high performance serial and parallel computer algorithms using MPI and OpenMP in Java platform for optimal use of AMP Optron Cluster . Data Analysis Platforms : R and MATLAB , familiarity with Python Programming Languages : Java C , shell scripting languages Perl , awk , grep and sed . Technologies : NMR

Senior Staff Computational Biologist . . . Technologies :

Senior Computational Biologist . . Versatile Bioinformatician and Data Scientist with 15 years experience deriving insights from multidimensional data using statistical and machine learning methods . Recent work entails a hands on approach through the full data lifecycle from raw instrument data collection to data munging , analysis , visualization and results write up Core skill sets : Hypothesis testing methods and regression models Machine learning for dimension reduction , clustering , and applying classification prediction algorithms Publication quality data visualization using ggplot and ploty for interactive plots and proficient in building apps in R Shiny Finding , assessing , and applying new tools and techniques to address specialized data or research study requirements . Managing core system and process elements of an applied bioinformatics lab , including database and web server administration , creation of data shares and pipelines , instrument interface development and configuration , and general data management . Applying my analytical expertise in an inter disciplinary environment that requires both guiding and learning from my collaborators , which include clinicians , investigators , and researchers . Tech used : R , R Shiny , Python , SQL , JavaScript and Bash . Technologies :

Director of AI research . We are building a research group working in the frontiers of deep learning . Machine learning researcher , with expertise in machine perception and computational biology . Current focus on reasoning and perception image understanding . Leading teams in academia and industry , I gained experience with the full research to product life cycle , from cultivating exploratory ideas , through testing prototypes , to shipping products . Expertise : Machine learning , Deep learning , Probabilistic models , Information theory , Computer vision , Transcriptomics , Computational Neuroscience , Vision and Language . . Technologies :

PHD Student . . PhD student in Biochemistry , studying ion channels with cryo EM and electrophysiology . Technologies : CryoEM

membrane proteins;structure

Research Scientist . Immunology , immuno oncology , the tumor microenvironment , endoplasmic reticulum stress biology , and drug development . . Self motivated molecular and cellular biologist , with 10 plus years of in vivo pharmacology experience from various preclinical species at the pharmaceutical environments , PD assays , PK PD relationships , POC studies , characterization of various animal models including cardio metabolic , thrombosis and immuno oncology models and 20 plus years of in vitro experience of molecular , biochemical and protein techniques , cell culture , immunoassays , and statistical analyses to elucidate pathways underlying the pathophysiology of cardio metabolic diseases NAFLD , Type 2 Diabetes ; Heart failure and thrombosis ; immunology , immuno oncology , the tumor microenvironment and endoplasmic reticulum stress biology . Extremely knowledgeable in overall basic laboratory techniques including high throughput screens , ELISA , Cell cultures including primary cell preparation and culture , transient and stable transfection ; DNA and RNA preparation , molecular cloning , PCR RT PCR ; recombinant protein expression and purification ; FPLC instrumentation , antibody purification , Western blotting , Immunofluorescence , Immunohistochemical staining and multi color FACS . Effectively communicated scientific concepts to varying backgrounds groups , managed teams with diverse skill sets and foster agile approach to effectively monitor progress and adjust approaches strategically to ensure success of the project . Active promoter of productive collaborative teams that have generated high quality data .. Technologies :

antibodies;proteins

Research Fellow . Division of Complex Drug Analysis : Characterized nanomaterials based drugs to investigate the quality of abbreviated new drug applications ANDAs and reference listed drug RLD using cryo SEM , and Raman analyses . Developed protocols for sample preparation via cryofixation using high pressure freezing and freeze substitution techniques . Collaborated with different research groups at FDA to assist in physiochemical characterization of drugs including liposomal based albumin nanoparticle bound paclitaxel , Cyclosporin , Bupivacaine , Degarelix , Tretinoin . . Experienced professional with a Ph.D. from University of Minnesota and demonstrated success to deliver scientific research skills with innovation through various intellectual properties and a start up company . 7 years of experience in bio nanotechnology including development of bioassay techniques , wet chemical synthesis of nanoparticles , and physiochemical characterization techniques of nanomaterial nanomedicines . Have been trained on wide range of analytical techniques including SEM , cryo electron microscopy , TEM , DLS , FTIR , Raman , Atomic absorption and IR spectroscopy , HPLC and other chromatographic methods . Proficient in Immunochemical ELISA , Western blot and Immunofluorescence microscopy and molecular techniques PCR , cloning and gene expression and hold two degrees in Biochemistry . Have experience with project management including proficient budgeting , assessing resource constraints and hiring appropriate candidates . Enjoys interacting with multicultural people , hiking and outdoor activities . Aspire to work in industry as an R D scientist , consultant and project manager .. Technologies : CryoEM;SLS DLS

carriers;characterization

Manager Production Support Validation . . Specialties : Downstream process development Downstream manufacturing Refolding Recovery by aqueous two phase partitioning Separation of intracellular membranes and purification of membrane proteins Target protein production for high throughput screening and structural analysis Protein expression , purification and characterization Yeast and plant glycolysis Plant respiration . Technologies :

membrane proteins;characterization;expression

Postdoctoral Scholar . . Data scientist with more than 10 years of experience in the fields of structural bioinformatics , molecular modeling , data science , and cryo electron microscopy cryo EM . Structural Bioinformatics and Molecular modeling Developed five methods and analysis workflows for protein structure modeling and peptide design . Modeled more than 10 protein structures and complexes using homology modeling MODELLER , loop modeling and protein protein docking of different biomolecules with Integrative Modeling Platform IMP https : integrativemodeling.org and AlphaFold2 to characterize protein protein interactions . Determined three large macromolecular complex structures by integrating information from experiments such as cryo EM and chemical cross linking using generative modeling techniques such as Bayesian inference . Performed protein sequence and structure analysis with multiple structural bioinformatics tools and databases . Predicted protein structures de novo using tools such as Rosetta and understanding of protein design methods . Programming and Data Science Developed multiple software tools using Python 8000 lines and libraries such as Biopython , Pandas and NumPy . Contributed to the code and maintenance of the Integrative modeling platform IMP software which is a molecular modeling package for modeling large macromolecular assemblies by integrating information from experiments and physical theories . Utilized version control systems such as Git and Unix based shell scripting to develop and maintain software . Designed workflow for handling large cryo EM image datasets for classification and 3D reconstructions . Performed computing tasks using high performance computing environments such as large HPC clusters . Applied machine learning tools such as PyTorch and Scikit learn to solve problems in structural biology . Communication and Project management Worked in multiple interdisciplinary teams to meet project goals remotely and independently . Communicated research findings through six publications and presentations at international conferences . Managed multiple research projects mentoring junior scientists and led teams at hackathons winning prizes .. Technologies : CryoEM

Senior Principal Scientist . . In the past 15 years , I have built computational platforms and trained predictive models to solve data centric problems in RNA biology , single cell genomics , molecular genetics , precision medicine , immuno oncology , and drug development for rare diseases . I have fulfilled technical lead and strategic oversight support roles in research , development , and clinical functions during the past 7 years in three early stage startups . I strongly believe that my scientific versatility and servant leadership style help me empower small collaborative teams to achieve well planned objectives and reach extraordinary goals . I have led teams through two stages of drug development target prioritization for IND enabling studies and target patient stratification in natural history studies . I am excited to increase the speed and success rate of modern bio pharma med projects as they fully enter the era of digital science . Specialties : computational molecular biology , bioinformatics , machine learning , predictive models of biology , large scale genomics , rare disease , precision medicine , single cell transcriptomics , early stage drug design and development , off target effects , lead optimization , experiment design , assay development , reproducibility .. Technologies :

Director of Manufacturing Sciences and Technology GTO . Provision of leadership to a team of Scientists with responsibility for providing scientific direction and support for the manufacture of commercial products . The MSAT and Product Technical Leads provide end to end technical support to internal manufacturing sites and Contract Manufacturing Organisations CMOs used by Alexion for production of commercial products , including support of Technology Transfers , on going process investigations , changes , validation , and process improvement initiatives . . Responsible for overseeing MSAT process and analytical activities to support commercial manufacturing with small scale lab models on behalf of Alexion by partnering with CLOs . . Maintain Technical Risk Register and mitigate same . Member of GTO leadership team , and BPOG L2 for DS Phorum . . An interest in science and manufacturing , led to a career in bio pharmaceuticals . A journey that has included start up of multiple new internal external manufacturing plants and associated technology transfer of development , clinical , commercial , and in licensed manufacturing processes through to successful regulatory filing and licensure . A key driver for me is knowing that the work I undertake daily has a positive impact on our patients lives , particularly ultra rare and rare diseases to deliver life changing medicines at Alexion . . I ve been fortunate to have had the opportunity to experience roles of increasing responsibility across small , medium and large sized companies , at small through to large scale cell culture and protein oligo purification processes for enzyme and hormone replacements , including monoclonal antibody therapies , in Manufacturing , Technical , Quality and SME roles . . Improvement of processes and understanding in development , technology transfer and post launch optimisation of commercial processes while maintaining a foundation of manufacturability has been an area of interest . . In more recent years , building high performing teams , providing leadership , and finding solutions and strategies to difficult problems have been a key area , with no challenge being too small to take on . . Technologies :

biologics;expression

Researcher in Digital Phenotyping . . Clinical Computational Phenotyping . Applying Computer Vision approaches to extracting clinically relevant information from photographs . Computational biology , inferring causative variants in next gen sequencing data . Previous experience : Detection and characterisation of transposable elements . Research within the topic of neurovirology . Focus on expression quantification and expression profiling of human endogenous retroviruses , this in particular pertaining to expression in diseases such as schizophrenia . Assay development of qPCR and melting temperature analysis . Computational biology techniques , next generation sequencing data , method development , transposable elements , neuroscience , virology .. Technologies :

Scientist III . . I have over a decade of experience in molecular virology with 7 years of experience in antibody virus interactions . My broad skills set includes cell molecular biology , assay development , clinical collaborations , library screening , NextGen sequencing , and data analysis using Python . I am interested in applying my experience developing new diagnostic tools , vaccination strategies , or antibody therapeutics and am open to many other opportunities .. Technologies :

antibodies;interaction

Senior Scientist . Lead early discovery projects on respiratory viral targets . Scientist with extensive experience in small molecule drug discovery ; developing assay technologies and elucidating compound mode of action in oncology and virology disease areas . Accomplishments range from streamlining assay processes and developing proprietary technology platforms to effectively presenting complex material tailored to a broad range of audiences in a clear , concise and persuasive manner . Specialties : Expertise includes in vitro enzymatic assay development , steady state and pre steady state kinetics , liquid handling robotics , and MTS compound screening and profiling .. Technologies :

small molecules;screening

Assistant Ing nieur . Laboratoire CiTCoM : Cibles Th rapeutiques et Conception du M dicament UMR 8038 CNRS Universit Paris Cit ; Nicolas LEULLIOT ; Equipe : Signalisation et transport membranaire responsable : Isabelle BROUTIN . Contexte : Mon quipe est sp cialis e dans l tude structurale des prot ines membranaires impliqu es dans la r sistance aux antibiotiques . Elle s int resse plus particuli rement l efflux actif des antibiotiques via quatre pompes tripartites de la bact rie Gram n gatif Pseudomonas aeruginosa . Nous menons ces recherches par des approches compl mentaires associant la biologie structurale cristallographie , SAXS , Cryo EM de l analyse fonctionnelle in cellulo . Missions : Production et purification des macromol cules biologiques prot ines membranaires essentiellement tudi es dans l ' quipe en vue de leur tude fonctionnelle et structurale . Utilisation de protocoles optimis s et participation la mise au point de la production de nouvelles prot ines recombinantes par biologie mol culaire mutag n se dirig e . Mise en place au laboratoire de la reconstitution des prot ines membranaires en nanodisques Pr paration d ' chantillons par coloration n gative pour la microscopie lectronique par transmission et enregistrement des images . R daction de protocoles et gestion des stocks de mat riels biologiques , des produits chimiques et des consommables . Formation des nouveaux utilisateurs , v rification du bon fonctionnement des appareils , planification des maintenances pour les appareils do nt j ai la responsabilit . Implication dans le comit technique du laboratoire Gestion de la r vision des Pipetmans l chelle de la facult . Formation des stagiaires de l ' quipe . Formations : Atelier INSERM 267 Formation th orique : Prot ines membranaires en syst mes reconstitu s : des derni res avanc es en recherche fondamentale aux applications th rapeutiques mars 2022 ; Bordeaux . Congr s : GDR APPICOM 2021 Novembre 2021 , Lyon . . . Technologies : CryoEM

membrane proteins;proteins;expression;structure

Charg e de Recherche CNRS . . Biochemist and structural biologist with expertise in protein engineering , protein interactions , crystallography and cryo electron microscopy . Skills in molecular biology , protein expression and purification , assay development , protein protein and protein nucleic acid interaction analyses , X ray crystallography , cryo electron microscopy . Team oriented , capable of managing and developing projects with excellent communication abilities . Guided and advised several graduate student and post docs .. Technologies : Xray;CryoEM

nucleic acids;proteins;engineering;interaction;structure

Senior Bioinformatician . Drug discovery , peptide analysis , NGS , workflow automation , decision support . Population genetics , bioinformatics , statistics , programming , omics , web technologies , information management systems , web design . Technologies :

Research Associate . New Antibody Product Research Department . . Technologies :

antibodies;developing

Drug Product Design and Development Scientist . COVID 19 mRNA vaccine formulation and process development Seasonal Flu mRNA vaccine formulation and process development . I am a nanotech scientist who combines nanomedical aptitude with mathematics and computer science to drive breakthrough understanding of cancer development through computational genomics . By advancing computational methods for early detection of oncogenesis and illuminating the complex cancer mechanisms I aim to find critical vulnerabilities and drug targets . Previously I developed innovative drug designs for the fields of oncology , immunology and rare diseases . Pfizer BTxPS 2020 Impact Award Winner for Outstanding Contributions to the COVID 19 vaccine . Patents holder for 2 novel therapeutics that I helped to formulate .. Technologies :

biologics;formulation

. . Driven by passion for protein chemistry and analytical techniques such as NMR , MS , HPLC , XRC and Cryo EM .. Technologies : CryoEM;NMR

proteins;structure

Senior Staff Scientist . . I 'm currently a senior scientist in Professor Tony Kossiakoff 's lab at the University of Chicago . My research is focused on dissecting the structure function relationship of membrane proteins using cryo electron microscopy and synthetic antigen binders sABs , which I generate using phage display libraries and in vitro selections . I lead a team of young scientists , with the goals of determining structures of proteins involved in bacterial homeostasis and pathogenesis and providing sAB reagents to the structural biology community . Our efforts here have led and contributed to over a dozen peer reviewed publications . Read more about our work here : https : kosslab.uchicago.edu . Technologies : CryoEM

membrane proteins;structure

Machine Learning Scientist . . I develop statistical machine learning methods for the analysis of biomedical signals , with the goal of improving patient diagnosis and treatment through translational research . I am passionate about data , algorithms , mathematical modeling and their applications in computational biology .. Technologies :

Oncology Bioinformatician . . . Technologies :

Alexander von Humboldt Research Fellow . . My research activity regarding the design and synthesis of novel anticancer agents with various mechanism of actions such as inhibition of kinases , organometallic enzymes as carbonic anhydrases and histone deacetylases in addition to their degradation using PROTACs .. Technologies :

molecular glues;small molecules;developing

PhD Student Institute for Molecular Biology and Biophysics Prof. Nenad Ban . Boehringer Ingelheim Fonds PhD fellowship 2019 2021 PhD Program Biomolecular Structure and Mechanism Life Science Zurich Graduate School Topic : Structural investigations of eukaryotic ribosomal complexes with cryo electron microscopy . On the lookout for fascinating opportunities in the life science industry consulting shaping my personal growth and career An open minded and solution oriented PhD candidate in structural biology with advanced project management skills Passionate about open science and empowering early career researchers . Technologies : CryoEM

proteins;structure

PhD student in Medicinal Chemistry and Teaching Assistant . PROTAC design and synthesis to explore dysfunction of the Ubiquitin Proteasome System UPS in cancer , group of Prof. L. Scapozza , Biochemistry Chemistry , Pharmaceutical Sciences . I am a Ph.D. student in Medicinal Chemistry with a background in Pharmaceutical Sciences . Passionate about medicinal chemistry and chemical biology , I like contributing to scientific research with creative and innovative solutions in potential areas of unmet medical needs .. Technologies :

molecular glues;developing

Principal Scientist Computational Biology . . I combine big data , machine learning and artificial intelligence to create sublime data products while simultaneously protecting data privacy . I lead organizations using the principles of science .. Technologies :

Computational Biologist . . . Technologies :

Senior Research Associate . . I 'm a Senior Research Associate at the Center for Computational Biomedicine in the Harvard Medical School . My research interests revolve around knowledge representation and reasoning . I 'm interested in the application of ontologies to improve information accuracy , management , and dissemination , and to facilitate knowledge discovery .. Technologies :

Bioinformatics Data Scientist II . . . Technologies :

Research Computing Consultant . . My research background is in computer science and microbiology , with extensive expertise in large scale genomic data . . Technologies :

Cryo EM expert . . Languages : French : Native speaker . English : Perfectly fluent oral and written . German : Spoken A2 B1 level , Writing A2 B1 level , reading A2 B1 level Deutschkurse LMU . Laboratory skills Biochemical : In vitro : Nucleic acid purification , modification and structure analysis . Detection methods Northern and Western blotting . Protein over expression and purification in native and denaturing conditions globular and membranes protein via HPLC , protein refolding and activity assays . Reconstitution and purification of ribonucleic complexes ribosome and mRNP complexes . Labelling of protein and nucleic acids radioactivity , fluorescence . Cell free expression system prokaryotic and eukaryotic . Chemical cross linking in vivo or in vitro . Immuno precipitation and purification procedure . Crystallization procedures protein , RNA and complexes . In vivo : Microbiology : working and cloning in Gram negative Gram positive bacteria , complementation assays , genomic tagging and gene knockout . Eukaryotic cell : yeast gene tagging and complex pull out . Cryo EM : Negative stain uranyl acetate . Checking negative stain on FEI Morgani transmission electron microscope . Cryo grid preparation , grid clipping . Data collection on Talos Arctica with EPU counting mode linear mode and Titan Krios Data collection on Titan Krios at CETEIC cryo EM facility , Brno Czech Republic Data collection on Titan Krios at the CSSB 3D structure reconstruction and modelling : Cryo EM 3D structure reconstruction : Single particle analysis : Spider , Relion , FreeAlign , ResMap , Sphire . 3D structure building : de novo RNA 3D structure modelling based on both sequences covariation and 2D structure probing constrain Assemble , Coot , Chimera . de novo 3D structure building using density maps Coot , Chimera , Phenix , Refmac . Crystallographic programs CCP4 . 3D structure analysis with molecular graphics software : PyMol , Coot , Chimera , ChimeraX. Informatics : Programming skills : Sequential programming language FORTRAN , shell scripting . Object oriented programming language C , perl , Java , Python . Statistic program R . Operating system Linux , MacOS , Windows and cluster knowledge . . Technologies : CryoEM

nucleic acids;proteins;structure

Post Baccalaureate Fellow . Computational biology researcher . hi . Technologies :

. . My main contribution to the field of electron microscopy has been the development of a support foil with holes of pre defined size , shape and arrangement , QUANTIFOIL together with Eugen Ermantraut . In general , my research was methodologically as well as biologically oriented and was focused on biomacromolecular complexes and also on cell biological systems . Specimen preparation techniques applied included negative staining , shadowing , vitrification and freeze drying in the one field and high pressure freezing , freeze substitution , embedding and sectioning in the other . I carried out three dimensional reconstructions of single particles via angular reconstitution and via random conical tilting , and of semi thin sections by tomography . I developed a correlative approach to fluorescent live cell imaging and electron microscopy . At the European Molecular Biology Laboratory EMBL in Heidelberg , I oversaw a STEM facility during the second half of the eighties and the beginning of the nineties , and carried out mass determinations in collaboration with several colleagues both inside and outside the EMBL . I contributed to establishing an infrastructure for high resolution cryo EM in two labs . My last publication is about the appearance of the power spectrum when the specimens thickness exceeds the microscope 's depth of field and about the information that can be retrieved from such a power spectrum with respect to the objective lens defocus and the specimen thickness .. Technologies : CryoEM

Senior Scientist , Protein Biochemistry and Biophysics . Support a broad range of drug discovery and development efforts that include screening and lead discovery , and detailed studies of ligand protein interactions ; Support drug lead discovery , optimization , and development through the application of protein biochemistry and biophysics ; Support the discovery and development of therapeutic targets ; Drive fit for purpose construct design , expression analyses , and purification protocol development to produce high quality protein reagents for screening and biophysics ; Responsible for characterization of protein using biochemical and biophysical methodologies to confirm folding , function , and binding competencies with know ligands and tool molecules ; Expert in construct design , protein expression using diverse expression systems mammalian , insect , and bacterial , and protein purification ; Proficiency in analytical techniques LC MS , DLS , SEC MALS , thermal shift assay to study protein folding and solution behavior ; Proficiency in production of challenging protein targets integral membrane proteins , intrinsically disordered proteins , multi protein complexes for biochemistry and biophysics ; Experience with biochemical and biophysical characterization methods enzymology , SPR , spectroscopy , and calorimetry to guide construct design ; Experience with structural techniques such as BioNMR and X ray crystallography ; Collaborative interactions with other members of the global , cross functional department ; Cooperative and collaborative use of internal expertise and resources ; Excellent organizational , analytical , and communication skills ; . I m a highly motivated and energetic research scientist with 14 years of experience in project management , team work , and creative problem solving skills with expertise in cancer research , target identification , and drug discovery . I 'm fascinated by how proteins function . Unlocking their function can expand our comprehension of health and disease states , leading to new therapeutic strategies and drugs , ultimately helping patients and making a difference in people s lives . That s what drives my passion . I enjoy learning and like to interact with people in a collaborative way . I 've managed projects in epilepsy and neurodegenerative diseases , leukemia , multiple myeloma , and prostate cancer . I 've worked with more than 40 different target proteins , excluding variants , for structural determination , protein protein interaction PPI characterization , biochemical and enzymatic assay development , and biophysical studies . Some of those targets were transcription factors , enzymes , scaffolding proteins , and oncogenic targets . Disclaimer All articles and news posted in my Linkedin profile are my own personal interests and not of my employer . They are intended to inform the general public and my network . Opinions of course are my own and not the views of my employer .. Technologies : Xray;ITC;SLS DLS;SPR;CD;NMR

idps;membrane proteins;proteins;small molecules;characterization;interaction;screening;stability;structure

Director of Operations , Stanford cryoEM center . I manage Stanford cryoEM service center staff and equipment A TFS Glacios , 2 TFS Krios , a fun little Morgagni , and associated prep supplies . I have managed the installation of the Glacios and we are currently installing an Aquilos FIBSEM . . . Technologies :

Bioinformatics Scientist . . My research has been focused on investigating semantic attribute approaches to improve machine learning models of patient prognosis and drug sensitivity . Spinoffs of this work include a large scale model selection training deployment framework and web applications to apply suites of hundreds of models to uploaded gene expression data . Previously , I helped kick start the informatics group at Baylor College of Medicine Human Genome Sequencing Center HGSC during the Human Genome Project ramp up . At the HGSC I developed significant parts of the Atlas Genome Assembly Suite , machine learning based QA software , GUI assembly visualization tools , a fast read mapping tool , and a rule based DNA sequence analysis pipeline . Before my segue into bioinformatics I worked at an electrical engineering consulting firm where I designed hardware and software for embedded digital signal processing systems . . Technologies :

Principal Scientist 1 . Provide separation science support for the drug discovery medicinal chemistry team at BMS in Lawrenceville , NJ . Use HPLC and SFC for achiral chiral small molecule analysis and separations . Shimadzu Waters Agilent instruments . Lab manager . Small molecule purification , HPLC LCMS SFC , analytical chemistry ; medicinal chemistry ; DNA encoded chemical libraries DEL . Technologies :

small molecules

Computational Biologist I . . I am interested in generating and integrating next generation sequencing NGS data so that we can further understand the mechanisms of transcriptional and epigenomic regulation on a cellular level . My doctoral research focused on developing approaches to understanding how stresses in particular , viral infection can modulate and interfere with gene regulation . In addition to writing software to analyze these data , I also performed experiments to validate my computationally derived hypotheses . Currently , I utilize these skills to work in research and development of pharmaceuticals that target epigenetic regulation in order to treat rare genetic diseases . I develop pipelines and perform analysis on a variety of projects for a suite of diseases in a variety of diseases and tissues with the aim of discovering and validating drug targets in a rigorous and reproducible manner .. Technologies :

Senior Scientist . Drug discovery and platform : protein expression purification biophysical binding HTS cryo EM and crystallography DEL and conformation selective binding screens integrative tractability workflows Major pipeline contributions : Human glycogen synthase glycogenin complex structures cryo EM with inhibitors for structure based design ; first author manuscript in revisions Expression to structure workflow leading to 20 small molecule inhibitor bound structures of a membrane protein complex cryo EM that drove 1000x potency increases DEL screen against a membrane protein in nanodiscs ; new molecules and key analogs . I am a protein biochemist with 8 years research experience working on challenging targets such as membrane proteins and oligomeric complexes . My current focus is the development and implementation of technologies to enable and accelerate drug discovery . Areas of expertise : Protein structure and structure based drug design Small molecule screening and biophysical characterization Protein engineering and combinatorial binding screens yeast phage display and DEL Mentorship and communication . Technologies : CryoEM

proteins;small molecules;characterization;engineering;expression;screening;structure

Research Associate II . . During my undergraduate career at University of Texas at Austin I was involved with lab work focusing on combining wet lab with the computer lab . As a recent Masters graduate from Taipei Medical University , I advanced my learning on virology to work on Coronaviruses , Flaviviruses , Picornaviruses , Retroviruses , and Rhabdoviruses . I 've done molecular docking of ligands onto enzymes and viral glycoproteins with experience in PyMol , UCSF Chimera , and Autodock Vina . Currently , I 'm a research technician at Scripps Research Mravic Lab looking at HIV and the mystery of its transmembrane regions . Aside from the education field I also worked at a Biomedical Tech start up called Reliant Immune Diagnostics and was a finalist for a queer innovation start up competition in Taiwan . I also earned a B.S. in Radio Television Film writing scripts , shooting short films , and learning how to direct and produce . Through this medium I hope to continue to create short films containing humor and drama about the queer experience as well as the Asian American experience . My short films , and Little Swimmers , is currently out , and I 'm currently working on a webseries called Existential Crisis Club . I am also a spoken word poet and have performed at Silk Club ATX in Austin , Texas , and The Salon in Taipei , Taiwan .. Technologies :

Associate Principal Scientist . In Vitro biochemical assays , PROTACs , Project Lead . . A dedicated scientist with a strong passion in early drug discovery . Strong expertise within target production , assay development and screening . Have worked with many different drug discovery projects from Hit Finding to Lead Generation as a core team member or discipline lead .. Technologies :

molecular glues;small molecules;screening

Subject Matter Expert Microfluidics . . I am passionate about developing disruptive solutions that improve life quality . My focus has been on the development of microfluidic technologies and its applications for life sciences , drug development , pharmaceutical and enzyme development . Key words : Biotechnology , Droplets , Microfluidics , Membrane Proteins , Drug Discovery . Technologies :

Scientist . . Enthusiastic scientist with a curious and ' go do ' oriented mind set . Experienced in planning , recording , interpreting , and communicating scientific data from a broad range of techniques applied to proteins , emulsifiers , and polysaccharides . Areas of expertise include : Protein Biophysics Chemical and physical analysis Project management Scientific communication Data analysis . Technologies :

proteins;characterization

Postdoctoral Research Fellow . . I am a biochemist with over 9 years as PhD student and Postdoc of life science research experience . I have a strong background in structural and molecular biology methodologies , with specific expertise in the following : X ray protein crystallography sample preparation , data collection , and data processing . Cryo EM specimen preparation , Vitrobot System , clipping , and data processing . Protein expression bacterial and mammalian cell expression systems and purification FPLC . Protein characterization SDS PAGE , BLI , SEC . Selection of neutralizing agents for viral infections EBV , HPIV and SARS related virus using yeast surface display . Molecular biology PCR , construct design , and cloning .. Technologies : Xray;CryoEM;BLI

proteins;characterization;interaction;structure

Postdoctoral Researcher . . I m a protein biochemist with major experience in the structural characterization of membrane proteins and their ligands . I work as a postdoc with Natalia Jura at UCSF and my scientific interest lies in developing an atomic scale understanding of how receptor tyrosine kinases regulate signal transduction across the membrane and how aberrant signaling causes human disease . I have lived and worked in many different countries and easily adapt to new environments . I believe that good science and its translation into medicines is a team effort and I am always open for exciting opportunities and collaborations .. Technologies :

membrane proteins;interaction;structure

Bioinformatics Scientist . . Scientist solving biological problems with computational tools . Extensive training in bioinformatics , mathematics , and computer science . Expertise in genomics , NGS , algorithm development , statistical data analysis , and modeling complex systems . Experience collaborating with a diverse set of research teams making important discoveries in the fields of neuroscience , immunology , genetics and epigenetics . . Technologies :

Undergraduate Researcher at Nogales Lab . Studying the Ska Ndc80 complex and its interactions with microtubules using cryo EM . Gained expertise in cloning , protein expressions and purification , and currently learning cryo EM experimentation . . Second year undergraduate at UC Berkeley majoring in Molecular and Cell Biology with an emphasis in Biochemistry and Molecular Biology , and minoring in Data Science with 4 years of experience in the field of molecular biology . Passionate about drug discovery and cancer biology with working and wet lab experience in molecular techniques , protein and enzyme analysis , cryo EM and immunological cytokines . Feel free to reach out to me through my email : nikhitkambdur berkeley.edu . Technologies : CryoEM

proteins;small molecules;interaction;structure

Director Fibrosis Biomarkers Hepatic and Pulmonary Research . . Assay Development Antibody Expert . Hard working with focus on my work in relation to customer and company success as well as personal . Good research and customer relations has high priority . Author and co author of more than 140 peer reviewed publications on ELISA , ECM , Assay development , preclinical models , clinical studies .. Technologies :

antibodies;characterization;developing

Senior Bioinformatics Scientist . . Resume : http : sha.wncho.com resume Contact : sh wncho.com Professional bioinformatics scientist , data engineer , and full stack software developer with 5 years of experience . Specializing in helping small to mid size biotech pharma companies with data storage architecture , application development , and delivering data driven insights . . Technologies :

Scientific Researcher . . Fellow PhD student of the Leibniz Graduate School on Aging , based at the Leibniz Institute on Aging Fritz Lipmann Institute FLI , Jena , Germany . Her research focuses on understanding the importance of sleep circadian rhythms on neuronal aging and protein aggregation disorders , such as Alzheimer s and Huntington 's disease . Since 2010 , she has conducted research related to sleep , sleep deprivation , memory , and protein aggregation mechanisms . She gained her MSc 2015 in Biology at the Federal University of Rio de Janeiro , Brazil , and her BSc and Teaching degree 2012 also in Biology at the State University of Rio de Janeiro , Brazil . Besides doing research , Isabela has also a fond interest in science communication and outreach activities . As part of her teaching degree , she developed a series of classes explaining the importance of sleep and sleep hygiene during adolescence , which became an ongoing State University of Rio de Janeiro s project . She had also an internship at the Roberto Marinho Foundation Brazil taking part in the promotion and organization of the Young Scientist Award . Since 2020 , she is a member of the Digital Communication committee of the European Sleep Research Society ESRS , bringing awareness to sleep related topics through social media content , webinars , and scientific events .. Technologies :

idps

Senior Scientist . . Structural biologist with an interest in membrane proteins 10 years of expertise in high resolution cryo EM Track record of solving challenging protein structures using single particle cryo EM Experience with expression and purification of eukaryotic proteins including membrane and DNA binding proteins and membrane protein crystallization Extensive knowledge of biochemical and biophysical techniques . Technologies : CryoEM

membrane proteins;structure

Researcher PHD Student . Cryo EM structural biology research of large membrane protein complexes . . Technologies : CryoEM

membrane proteins;structure

Undergraduate Researcher . This summer I am working under the guidance of Dr. Leonid Peshkin and Professor Marc Kirschner , founding chair of Systems Biology at HMS . I will be working on a kinase regularization , a machine learning project . I am grateful for the opportunity . Hello I 'm Anna Kondylis . Technologies :

Principal Bioinformatician . . I am a research bioinformatician with expertise in managing and analysing Big Data within the fields of epidemiology , genomics and drug discovery . I am currently based in the UK working remotely for a Drug Delivery and Therapeutics company in Perth , Western Australia Having been in the field since 2001 , I have developed a substantial knowledge in the application of a wide range of bioinformatics methods to a broad spectrum of biological problems . During my appointment with the University of Cambridge , UK , I single handedly established the core bioinformatics facility at the Cambridge Institute for Medical Research CIMR . Following on from the success of this facility , in 2008 I moved to the Telethon Kids Institute , Perth WA to lead an institute wide programme of Bioinformatics and in 2014 I was invited to join the Institute 's Drug Discovery Group Phylogica to lead all bioinformatics activities and strategy within the company . I have continued in this role as the company migrated to the Harry Perkins Institute and rebranded as PYC Therapeutics . In 2018 I joined part time the Telethon Kids Institute 's Computational Biology group led by A Prof Timo Lassmann where I was primarily responsible for maintaining a computational diagnostic pipeline for the discovery of causal genomic variants in rare disease patients as part of the SeqNextGen project . I am also concurrently responsible for the development of the IT Infrastructure that underpins the research activities of the NIH funded MINERvA Autism study , which enables the combined analysis of significantly large autism registry datasets housed at separate international sites across Europe the USA and Australia . In each role I have been responsible for the installation and maintenance of all bioinformatics hardware and software and the development of custom software to ultimately provide bioinformatics solutions to research questions . This includes the design and implementation of tools to manage and analyse large scale epidemiological data e.g. ViPAR and the rapid processing and analysis of high throughput sequencing and genomic data e.g. FusionFinder , PhySeq , GenIE . . Technologies :

Graduate Student Researcher . Performed molecular modelling of protein ligand binding by docking oligosaccharide ligands into X ray and Cryo EM structures of COVID 19 spike protein and other proteins Performed binding free energy calculations with MM PBSA MM GBSA and alchemical free energy simulations using SIRE OpenMM molecular dynamics started from the modelled structures . Calculated ensemble averaged NMR J couplings by performing DFT calculations on sampled structures from molecular dynamics simulations Force field parametrization of modified carbohydrate ligands for molecular dynamics studies Researched quantum chemical reaction path optimization methods and accelerated ab initio molecular dynamics simulations to explore and characterize mechanistic pathways Investigated minimum energy pathways of biologically relevant mechanisms Initiated and maintained collaboration with an EPR lab to investigate a radical mechanism hypothesis Developed features to open source software packages written in Python to allow users to specify force field parameter files and dielectric constants in automated workflows Maintained detailed electronic lab notebook to update PI and collaborators . Computational chemist with skills that span quantum chemistry , molecular modelling , molecular dynamics and interested in a career in early phase drug discovery and development .. Technologies : Xray;CryoEM;NMR

proteins;structure

Projektleiter . . Breaking down complex problems into palpable questions and finding ways to make the step from data to insights is at the core of the skill set that I acquired during my studies of physics and my subsequent PhD in the field of molecular biophysics . Embedded in an international , interdisciplinary research network bundling biophysical , biochemical and medical expertise , I gained extensive experience in developing and validating biophysical assays , conducting scientific experiments , analyzing and interpreting data , and communicating my results .. Technologies :

characterization

Senior Staff Scientist . . . Technologies :

Research Scientist II . Structural and functional analysis of murine norovirus capsid , glutamate dehydroginase and LCIB . Protein X ray crystallography , Cryo electron microscopy . Processing and analysis of Cryo EM data . Virus capsid reconstruction . . . Technologies : Xray;CryoEM

proteins;structure

Chief Bioinformatician . . Goals To obtain a senior leadership position with international impact within the Bioinformatics or NGS field in a world class academic or commercial organization . To build and lead a team to work on mission critical projects while maintaining strong interactions with internal and external customers . Key attributes I am an enthusiastic team player with first class analytical , design and problem solving skills . I am equally comfortable working at a detailed level and with the big picture .. Technologies :

Professor at University of Vienna . Assistant Professor at the Center of Molecular Biology . Mechanism of nuclear gene expression regulation My group uses both biochemical and structural biology methods to mechanistically understand the regulation of gene expression . We are particularly interested in RNA metabolism in the nucleus : How are large areas of the genome selectively repressed and how are unwanted RNAs degraded after transcription if they have escaped the first control point We use an integrative structural biology approach combining different methods such as X ray crystallography and cryo electron microscopy to gain insights into the function of the protein complexes involved . . Technologies : Xray;CryoEM

proteins;structure

Graduate Student . Project 1 : Crystal Structure of Influenza Virus Matrix Protein and Its Biochemical Function Aim : Solve the atomic structure of DM1 and reveal cooperation of its domain in realizing biochemical functions Contributes : The structure of M1 was modeled with software AlphaFold2 , Phenix , HKL2000 , DALI , etc . Its biological function and the role of each domain was tested by liposome flotation , fluorescence polarization and pull down assay . Project 2 : KAT2A acts a histone H3 transferase Aim : Solve the atomic structure of KAT2A together with different ligands and reveal the specific residues involved in the binding site Contributes : Co crystallized KAT2A and multiple ligands and solved the structure . Residues involved in the binding site were mapped through superimposition among KAT2A interested ligand , KAT2A succinyl CoA , KAT2A acetyl CoA. Project 3 : Cohesin SA2 are RNA binding proteins and its N terminal domain is responsible for the binding Aim : Solve the structure of SA2 and analyze the RNA and DNA binding ability of both full length SA2 and multiple truncated versions of SA2 Contributes : Preliminary structure of SA2 was solved through Cryo EM . Their RNA and DNA binding ability was detected through fluorescence anisotropy assay using TECAN plate reader . . Ph.D. candidate in structural biology at Rice University . I worked on tumor targeted therapy and immunotherapy during my bachelor study as well as in the Chinese Academy of Science . I mainly worked on mammalian cell culture and animal model building at that time . And then I dived into more fundamental research in the structural biology area and study about the viral protein structure . I have been working on multiple expression systems including E.coli , insect cells , and mammalian cells . Skills : Structure biology : PCR , Protein Purification , Affinity Chromatography , Ion Exchange Chromatography , FPLC , Transmission EM , Cryo EM , Crystallography Biochemistry : Western Blot , Immunoprecipitation , Liposome Flotation Assay , Fluorescence Anisotropy , ELISA , Flow Cytometry , TCID50 and LD50 Measurement , Periodic Acid Schiff stain , Feulgen stain , paraffin section and hematoxylin erosin stain Cell Animal : E.coli Culture , Insect Cell Culture , Mammalian Cell Culture , Animal Model Building with Mouse , Drosophila and Rabbit , Drosophila Melanogaster 's Hybrid Experiment , Nude Mouse Mouse Lavage , Mouse Subcutaneous Injection Computer Science : Python , R , MySQL , PostgreSQL , MongoDB . Technologies : CryoEM;FP

proteins;interaction;structure

Graduate Teaching Assistant . Expected graduation August 2022 Graduate Student in the Chemistry and Biochemistry department at the University of Arkansas . Project Title : Structural Determination of Collagenases G and H from Hatehewaya histolytica . Tasked with determining the structure of two bacterial collagenases primarily using Small Angle X Ray Scattering SAXS , Cryo EM , and limited proteolysis SDS PAGE analysis . Additionally tasked as a regular TA for chemistry teaching labs , and summer lecture courses . Proud mentor of 9 undergraduate students and the awarding of 7 undergraduate honors grants . . An experienced graduate with a history of working in the life science field . Skilled in Learning Assistance , Communication , Molecular Biology , and Biochemistry . Hoping to pursue a career in the life sciences . Advocating for healthy work life balance for students . Having issues or questions facing undergraduate graduate studies Please reach out . Technologies : Xray;CryoEM

proteins;structure

Scientist for Cryo Electron Microscopy . . . Technologies : CryoEM

structure

Bioinformatics Scientist . support in algorithm development and implementation of statistical modeling and machine learning design data imputation algorithm for missing and minor nutrient value in food nutrient database design bioinformatics analysis pipeline for the NGS based genetic panel test support in NGS panel product design lose 20 pounds with GB HealthWatch 360 Moble apps . 100 hard worker ; 90 quick learner and critical thinker ; 80 team worker ; 70 statistical modeling and machine learning implementer ; 60 computer programmer and 50 biologist . Sound skills in both statistics and machine learning . Experienced in apply , modify and design algorithms to analysis dataset in bioinformatics research projects . Familiar with the current bioinformatics trend . Understand the concept about molecular biology , cancer genomics , pharmacological and pharmacogenomics study . Experienced with common process pipeline of dataset in the bioinformatics area such as Microarray , ChIP Seq , RNA seq , MBDCap Seq , etc . Skilled in high dimensional data visualization and analysis , familiar with the state of the art feature selection , dimension reduction methodology and modern data visualization technique . Familiar with public available data portal and tools such as GEO , TCGA , UCSC , DAVID . Solid record of publication in peer reviewed journals and presentations in regional and international conference . Strong written and verbal communication skills in English and Chinese . Strong commitment to team environment dynamics with the ability to contribute expertise and follow leadership directives at appropriate times . Computer software skills : MATLAB , R , C , JAVA , SAS , Microsoft office . Research interest : Bioinformatics Computational biology Large scale data analysis Algorithm development Feature selection and dimension reduction Statistical Modeling Contact : carter.ma gblifesciences.com work chifeng.ma yahoo.com personal cell 210 601 5097 all time . Technologies :

Scientific Engagement Manager . . I have 11 years of work experience in the field of Bioinformatics , with expertise in handling multi omics datasets . I have designed pipelines workflows on next generation sequencing such as genomics , proteomics , metagenomics , transcriptomics NGS datasets . I have used machine learning techniques to learn from NGS datasets . I have designed and managed SQL databases . I am proficient in R , Python , PostgreSQL , Linux , Database development management . I am looking to expand my expertise and insights gained from handling multi omics datasets . I possess deep inclination towards learning advanced computational and statistical methodologies , new sequencing technologies and application of well established concepts and techniques in the field of Bioinformatics . I am a quick learner and I work very well either independently or as a part of a team . Through these years of working in the field , I have led and managed teams and understood the nuances of what makes a team efficient and strive towards a common goal . With the multi omics experience , I am come well equipped to handle any kind of omics dataset and learn quickly and efficiently about the current trends in the field . I look forward to working with intelligent and scientifically driven individuals who will not only help me hone my skills but also strive towards to a greater goal of serving the life sciences industry .. Technologies :

Scientist Formulation Development Wetenschappelijk medewerker formulering . . Jolanda is an enthousiastic , motivated and ambitious industry pharmacist , with a passion for drug product development . She is a well organized , data driven , analytical professional currently working as a Scientist in formulation development in biotechnology industry . Her passion is to solve the challenges related to drug product development in the various stages of the product towards the market . Jolanda is skilled in formulation development of small molecules , vaccines , proteins and liposomes , working under GLP and GMP conditions , setting up relevant and lean experiments using DoE and interpretation of the resulting data of a wide variety of analytical techniques . She has a strong scientific mindset , but is also able to see the business perspective of the study results . Jolanda likes working in a team : Together Everyone Achieves More is a strong value for her . . Technologies :

biologics;carriers;proteins;formulation

Senior Research Scientist . Investigated novel molecular glues for targeting AML cells which involved studying the mechanism , establishing in vitro and in vivo efficacy assays , finding therapeutic index in mouse and human systems , pharmacodynamics of targets in AML mouse models . Discovered that IKZF2 regulates chromatin accessibility of HOXA9 self renewal gene expression program and inhibits a C EBP driven myeloid differentiation program in Leukemic Stem Cells . Investigating the role of RNA binding protein , Musashi 2 MSI2 in Leukemic Stem Cells revealed that MSI2 maintains translation of MLL fusion targets required for LSC function . Studying the role Msi 2 in Hematopoietic Stem Cells uncovered that MSI2 regulates translation of TGF beta signaling molecules to maintain myeloid biased HSC and myeloid reconstitution . Studying the roles of novel regulators required for stem cells in normal hematopoiesis and leukemia , aimed at finding new therapeutic targets for treatment of hematologic diseases . Implementing genetic mouse models , flow cytometry and functional genomic tools to understand underlying mechanisms . Current work involves using molecular glue degraders to target leukemic cells in vitro and in vivo involving primary patient cells and PDX . Have strong background using different cancer mouse models of blood , colon and ovarian cancer .. Technologies :

molecular glues;nucleic acids;small molecules;interaction;screening

Bioinformatician : Research Associate . A genetic based multi tissue classification of human ageing . . I am a computer scientist with a good knowledge of mathematical modelling techniques , programming , artificial intelligence applications and methods , and microarray analysis . I have excellent background in developing 2D models and simulations for dynamic behaviour of tumour . I have good command on programming languages including Java , Matlab , Python , C and C . Regarding my teaching experience I worked as teaching associate for almost two years at University of Bradford , UK and also completed a teaching placement at Grange Technology College GTC , Bradford . During my teaching experience , I helped students during the tutorial sessions and in individual meetings . I prepared and delivered lectures to undergraduate and postgraduate students including real time systems RTS , information engineering IE and programming languages Java . I have extensively worked in a multidisciplinary environment during my research career . I am experienced and skilful in wide range of experimental techniques and research methodologies .. Technologies :

Postdoctoral Researcher . cryoEM project management from sample preparation to Titan Krios day to day operation including data acquisition and processing , model evaluation and publication design , data acquisition and evaluation of structural biology projects . The function of a living cell is defined by the activity and interactions of its protein complexes . Understanding the properties of these interaction networks is necessary to predict cellular fate , in particular during malfunctions in disease . I am integrating systems and structural biology approaches to generate models of pathways and protein complexes . I studied genetic interaction networks of histone mutants to gain insights to transcriptional regulation as well as to extract structural models of protein complexes involved in chromatin biology . For the past years I have returned to using cryo electron microscopy single particle analysis to study protein protein interactions in a close to native state . Here my research is centered on protein complexes of the ubiquitin proteasome pathway , in particular in the elucidation of transient interactions . Moreover , I am continuing my early stage research of viruses and plants , to gain insights of viral protein structures as well as the assembly process of photosystem II .. Technologies : Xray;CryoEM;SLS DLS;MST;AUC;DSF

proteins;structure

Thiel Fellow . . . Technologies :

Head of Biomedical Research . . Computational chemist specialized in statistics , computational modeling , software development , and data analysis . Experienced working in cross disciplinary teams , and leading projects . Exceptional communication skills , with seven awards for conference presentations .. Technologies :

Principal Curator and Disease Selection Team Lead . . I am proud to work for Healx , an amazing startup biotech company in Cambridge , UK . Healx harnesses scientific insight into rare disease with AI and Big Data to identify drugs which can be repurposed for rare disease patients . I work within a team of scientific curators whose task is to identify potential leads and understand all aspects of rare disease pathobiology . Healx curators work alongside AI technicians , bioinformaticians and pharmacologists , as well as key opinion leaders , charities and patient groups , in order to refine predictions of potential drug targets that can ultimately undergo clinical testing and be brought to market . Such work is extremely rewarding . I have a university education in molecular biology , molecular evolution , phylogenetics and biostatistics with extra curricular training in historical database inquiry . I previously worked as a scientific database curator at the European Nucleotide Archive at EMBL EBI for nine years , dealing with data standards and curation in taxonomy , biological samples , sequencing traditional and nextgen and feature annotation . Prior to that , I worked as a computation biologist in the Sanger Institute 's HAVANA team for just over three years . There I conducted genomic annotation on the human genome as well as contributing the annotation of eight haplotypes of the human MHC region to the international HapMap project . Skills : Rare Disease Biology , Molecular Biology , Molecular Evolution , Database Curation , Biological Reporting Standards , Genomic Annotation , Biocuration , Phylogenetics , Biostatistics and general Computational Biology .. Technologies :

Postdoctoral Researcher . Designed a modular live cell fluorescent barcode that can provide longitudinal imaging in neuron development . Developed a magnetic cell sorting technique with genetically modified cell lines to improve initial FACS sorting by 20 Demonstrated capability and expertise in the following : fluorescent imaging ; different cloning strategies ; fluorescent probe design ; cell segmentation ; and CRISPR . Worked on a collaboration for CRISPR knock in for studying protein complexes with cryo EM determine candidacy to improve future drug screens . Postdoctoral Researcher in Bo Huang 's Lab at UCSF generating live cell barcodes for longitudinal imaging . Working towards designing these for organoid models . Research interest : Theranostics ; nanoparticles ; bio imaging ; cell culturing ; 3D printing ; lab on chip ; assay optimisation and development . . Technologies : CryoEM

Research Assistant . Automising internal workflows NGS prep and protein purification using Opentron system . Upscaling and optimising procedures for antibody screening with deepCDR . Contributing to the establishment and growth of ETH start up spin off company deepCDR . Applying bioinformatics and deep learning tools to antibody research and engineering . . . Technologies :

antibodies;engineering;expression;screening

Researcher . Working under Dr. Bob Lahue to develop a tri nucleotide repeat expansion assay as part as of project with other academic and commercial partners . . Research scientist with project management experience in a GMP environment . Currently a project leader at Charles River Laboratories in their Biosafety , Cell Based Assays and Virology Department . Previously worked at Fusion Antibodies , developing a mammalian display platform for antibody discovery . Previously worked at Roche Innovation Centre Zurich Roche Glycart in the cell and molecular technology department , developing biological tools to support the ongoing research there . Engineering tumor cell lines , immune cells and organoids via viral systems and transposon systems , as well as CRISPR engineering to create knock outs and for targetted integration of transgenes . . Experienced in 2d and 3d cell culture . Previously worked at Roche in their Pharma R D division Penzberg Germany with the task of developing stress fermentation models for better evaluation of CHO clones for suitability in large scale fermentations . Also introduced automation to their 2L CHO fermentation process . Recently graduated with a Master 's in Bio Process Development from the Mannheim University of Applied Science . . My work history to date has had a large emphasis on the following topics : mammalian cell line engineering and cell culture , genomics , biomedical imaging , medical devices spectroscopy , optics , biochemistry and regenerative medicine . I have been exposed to many different technical fields and have performed very well in them . I am a person who contributes positively to any professional environment . I am always happy to make new connections on LinkedIn . . Technologies :

Senior Business Analyst . Business analysis for the development of a FAIR data model and data ingestion flow of multi omics data . . I help pharma companies to switch into Agile in their IT projects to get the best performance . Experienced IT consultant with strong technical background and problem solving skills . More than 15 years experience as a Business Analyst , Bioinformatics Researcher and Software Developer . Computer Science Degree . Sun Certified Java Programmer and Certified Scrum Master . Ignite program on innovation at Stanford University . Extensive experience in Agile methodology and gap analysis . Requirement elicitation , Stakeholder discovery and mapping , creation of backlogs for MVP , Workshops , Demos , coaching and mentoring Business Analysts . Excellent communication skills . Key Skills : Computer Systems Validation CSV documentation : writing of User Requirements Specification URS , Functional Specification FS , Traceability Matrix . User Stories INVEST standard , Kanban Scrum Board Management , Backlog Prioritisation , User story mapping , Behaviour Driven Development , Refinement Sessions eg 3 amigos , Process Mapping for Gap Analysis BPMN diagrams , SCRUM , Product Roadmap Definition , Stakeholder Management What can Agile4Pharma do for you : Lead your company transition into Agile in a tailored way Train your Business Analyst team to be the driving force for the change Fine tune the software development process to make it high performance Establish a Continuous Improvement Model Contact me for more information and I will be pleased to discuss with you the best options for your company : hello agile4pharma.com . Technologies :

Manager CMC Management RNA . DS Lead . I love to interact with people my colleagues , people from different fields or with different background . I am caring and helpful . Regarding work , I am reliable and very critical with my results . I love new challenges and approaches . To recharge I seek the woods and mountains , either climbing , hiking or cycling . In the past 2 years I have been working for Heidelberg Immunotherapeutics . Starting as a Research Associate in the preclinical development team I 've been helping to characterize the epitope of the company 's anti HSV 1 2 antibody and proving its function in the mouse model . In addition , I started to work as a CMC porject manager , managing stability studies and basically everything concerning the IMP at the CMOs end . In the same way , I 've been supporting the clinical trial managers with everything regarding the IMP for two phase II clinical trials such as shipping or contributing to the IMPD and other essential documents . Bofore , I worked for Horizon Discovery and The Antibody Lab . I mastered my skills in cell culture up to the 10L bioreactor level and in various molecular biology techniques . Using CRISPR Cas , working with iPSCs and developing reporter cell lines or antibody secreting cell lines for example . What I enjoyed most during this time : to be involved in project design , streamlining processes and improving results . I finished my MSc with emphasis on immunology . During my thesis , I had the chance to learn the complex patch clamping technique and doing electrophysiological measurements . Between 2009 and 2011 , I gained my first serious hands on experience in the lab at the INMR in Sydney as part of my BSc program and thesis . At the INMR I established a method to isolate primary cardiomyocytes from the mouse heart for example . Last but not least , as a student and between jobs I always worked in outdoor sport shops 10 year experience . Having the opportunity to share my outdoor travelling experience with customers and helping them to find the best product and technology according to their needs . Happy to connect cheers . Technologies :

antibodies;characterization;engineering;stability