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RESULTS The only observed complication was cervical stenosis : zero cases in the laser group , one case in the LEEP group and four cases in the cold knife group ( laser versus cold knife : P = 0.03 ; LEEP versus cold knife : P = 0.06 ) . |
RESULTS Fifty pregnancies were observed in 39 patients . |
RESULTS First and second trimester outcomes of pregnancy were without complications . |
RESULTS One patient treated with the LEEP presented with a premature rupture of membranes and premature labor at 36 weeks . |
RESULTS A total of nine cesarean sections were performed with two cases for cervical dystocia . |
CONCLUSIONS There is no major difference in obstetrical outcome between the three techniques . |
###15897479 |
OBJECTIVE To determine whether macronutrient composition of a hypocaloric diet can enhance its effectiveness and whether insulin sensitivity ( Si ) affects the response to hypocaloric diets . |
METHODS Obese nondiabetic insulin-sensitive ( fasting insulin < 10 microU/mL ; n = 12 ) and obese nondiabetic insulin-resistant ( fasting insulin > 15 microU/mL ; n = 9 ) women ( 23 to 53 years old ) were randomized to either a high carbohydrate ( CHO ) ( HC ) / low fat ( LF ) ( 60 % CHO , 20 % fat ) or low CHO ( LC ) / high fat ( HF ) ( 40 % CHO , 40 % fat ) hypocaloric diet . |
METHODS Primary outcome measures after a 16-week dietary intervention were : changes in body weight ( BW ) , Si , resting metabolic rate , and fasting lipids . |
RESULTS Insulin-sensitive women on the HC/LF diet lost 13.5 + / - 1.2 % ( p < 0.001 ) of their initial BW , whereas those on the LC/HF diet lost 6.8 + / - 1.2 % ( p < 0.001 ; p < 0.002 between the groups ) . |
RESULTS In contrast , among the insulin-resistant women , those on the LC/HF diet lost 13.4 + / - 1.3 % ( p < 0.001 ) of their initial BW as compared with 8.5 + / - 1.4 % ( p < 0.001 ) lost by those on the HC/LF diet ( p < 0.04 between two groups ) . |
RESULTS These differences could not be explained by changes in resting metabolic rate , activity , or intake . |
RESULTS Overall , changes in Si were associated with the degree of weight loss ( r = -0.57 , p < 0.05 ) . |
CONCLUSIONS The state of Si determines the effectiveness of macronutrient composition of hypocaloric diets in obese women . |
CONCLUSIONS For maximal benefit , the macronutrient composition of a hypocaloric diet may need to be adjusted to correspond to the state of Si . |
###8182401 |
OBJECTIVE To compare the effects of dry needling of myofascial trigger points in the neck region to metoprolol in migraine prophylaxis . |
METHODS Randomized , group comparative study . |
METHODS patients , investigator and statistician were blinded as to treatment , the therapist was blinded as to results . |
METHODS Outpatient pain clinic in the northern Copenhagen area . |
METHODS Patients were referred by general practitioners or respondents to newspaper advertisements . |
METHODS Included were patients with a history of migraine with or without aura for at least 2 years . |
METHODS Excluded were persons with contraindications against treatment with beta blockers , chronic pain syndromes , pregnancy or previous experience with acupuncture or beta-blocking agents . |
METHODS A total of 85 patients were included ; 77 completed the study . |
METHODS After a 4-week run-in period , patients were allocated to a 17-week regimen either with acupuncture and placebo tablets or to placebo stimulation and metoprolol 100 mg daily . |
RESULTS Both groups exhibited significant reduction in attack frequency ( P < 0.01 ) . |
RESULTS No difference was found between the groups regarding frequency ( P > 0.20 ) or duration ( P > 0.10 ) of attacks , whereas we found a significant difference in global rating of attacks in favour of metoprolol ( P < 0.05 ) . |
CONCLUSIONS Trigger point inactivation by dry needling is a valuable supplement to the list of migraine prophylactic tools , being equipotent to metoprolol in the influence on frequency and duration ( but not severity ) of attacks , and superior in terms of negative side-effects . |
###17217318 |
OBJECTIVE This study aimed to evaluate the effects of monophasic estrogen-progestogen therapy on the sexuality and climacteric symptoms of postmenopausal women . |
METHODS A prospective , randomised , double-blind , crossover , placebo-controlled , single-centre study was carried out over a total of 12 consecutive months in 40 postmenopausal women with an intact uterus who had no contraindications to hormone therapy . |
METHODS Patients received 17beta-estradiol 2mg in combination with norethisterone acetate 1mg ( Cliane ) daily for 6 months or one placebo tablet daily for 6 months . |
METHODS The tablets were identical in appearance . |
METHODS After 6 months , the groups were crossed over and the patients were followed up for another 6 months . |
METHODS The groups were homogenous with respect to age , height , bodyweight , body mass index and race . |
METHODS For the statistical analysis , the group receiving hormone therapy was referred to as group A and the placebo group was designated group B , irrespective of the placebo/hormone therapy sequence . |
RESULTS In group A there were fewer hot flashes ( F = 22.85 , p < 0.01 ) and an improvement in sexual interest ( F = 5.55 , p < 0.05 ) . |
RESULTS The sequence in which the medication was received resulted in a statistically significant difference with respect to dyspareunia ( F = 9.65 , p < 0.01 ) and satisfaction with the duration of penetration ( F = 6.58 , p < 0.05 ) . |
RESULTS In the intrapatient analysis of variation with respect to orgasmic capability and the presence of dialogue with partner regarding the couple 's sexual life , whether the placebo was taken prior to or following hormone therapy was significant ( F = 17.12 , p < 0.001 and F = 7.10 , p < 0.05 , respectively ) . |
CONCLUSIONS Monophasic estrogen-progestogen therapy has a beneficial effect on sexuality and on hot flashes in postmenopausal women . |
###19852282 |
OBJECTIVE To investigate the clinical effect of the Chinese medicinal preparation Shengling Capsule on patients with oligoasthenospermia . |
METHODS A total of 270 male patients with infertility induced by oligoasthenospermia were equally divided into a treatment and a control group , the former medicated with Shengling Capsule at the dose of 1.6 g tid , and the latter given Vit E at 50 mg tid , both for a course of 12 weeks . |
METHODS Then we analyzed the changes in the patients ` seminal parameters and the pregnancy of their wives . |
RESULTS After 12 weeks of medication , both the seminal parameters of the patients and pregnancy of their wives were remarkably improved , with extremely significant differences from pre-treatment and the control ( P < 0.01 ) . |
CONCLUSIONS Shengjing Capsule can improve sperm motility and vitality as well as sperm count . |
CONCLUSIONS With few adverse effects , it can be used as a safe and effective therapeutic for male infertility induced by oligoasthenospermia . |
###9072052 |
OBJECTIVE To assess the usefulness of HELISAL in the diagnosis of Helicobacter pylori infection by comparing it with ELISA , JATROX and histopathologic findings . |
METHODS Randomized prospective study . |
METHODS Sixty-one patients , thirty-three males and twenty-eight females , 18-73 years old , submitted to esophagogastroduodenoscopy . |
RESULTS The sensitivity of HELISAL when compared to ELISA test was 60.8 % , the specificity 73.3 % , the positive predictive value 87.5 % , the negative predictive value 37.9 % , and the kappa index 0.26 . |
RESULTS When compared to histopathologic test : sensitivity 60.9 % , specificity 65 % , positive predictive value 78.1 % , negative predictive value 44.7 % , kappa 0.28 . |
RESULTS When compared to JATROX , sensitivity 57.7 % , specificity 62.5 % , positive predictive value 81.2 % , negative predictive value 34.4 % , kappa 0.21 . |
CONCLUSIONS The sensitivity of HELISAL test is lower than that of other compared tests , and the negative predictive value is very low . |
CONCLUSIONS The specificity and the positive predictive value are higher than the sensitivity . |
CONCLUSIONS The kappa index shows a very low concordance . |
###10510951 |
OBJECTIVE To evaluate the effects of simvastatin on serum lipids and insulin sensitivity in Type 2 diabetic patients with hypercholesterolaemia . |
METHODS A double-blind , randomized , placebo-controlled and two-period crossover study . |
METHODS After a 2-month run-in , 19 eligible Type 2 diabetic patients with hypercholesterolaemia were randomized to receive either simvastatin or placebo for 3 months , exchanging their treatment thereafter for another 3 months . |
METHODS Blood samples were taken in month 0 and at monthly intervals to measure serum lipids and indices of glycaemic control . |
METHODS An euglycaemic insulin clamp was performed in months 0 , 3 and 6 to assess change of insulin sensitivity . |
METHODS The amount of glucose infused during 90-120 min of the clamp ( M ) , and the mean values of serum insulin during 90-120 min ( I ) were measured . |
METHODS The M and M/I ratio were used to represent the in vivo insulin sensitivity of the subject . |
RESULTS Simvastatin significantly reduced serum total cholesterol ( TC ) by 23 + / -18 % and low density lipoprotein-cholesterol ( LDL-C ) by 30 + / -26 % . |
RESULTS It did not alter glycaemic control . |
RESULTS The M-values and M/I ratios were similar in both groups in each period and no drug effect on insulin sensitivity could be identified . |
CONCLUSIONS Simvastatin significantly reduced the serum TC and LDL-C levels without alteration of insulin sensitivity in Type 2 diabetic patients with hypercholesterolaemia . |
###10871561 |
BACKGROUND Premenopausal African American women have a 2-3 times greater incidence of coronary heart disease ( CHD ) than do white women . |
BACKGROUND The plasma lipid responsiveness to dietary fat , which may be associated with CHD , has not been adequately studied in premenopausal African American or white women . |
OBJECTIVE The objective of our study was to compare the effect of diet on fasting plasma lipids and lipoproteins and postprandial lipemia in premenopausal African American and white women . |
METHODS Thirteen African American and 9 white healthy premenopausal women were fed a low-fat , high-fiber diet and a high-fat , low-fiber diet for 4 wk each in a randomized crossover design . |
METHODS Fasting plasma lipid and lipoprotein concentrations and the 24-h plasma triacylglycerol response to a standard fatty test meal were measured at the end of each dietary period . |
RESULTS Plasma total and LDL-cholesterol concentrations were higher after the high-fat , low-fiber diet in both white and African American women ( P < 0.0001 ) . |
RESULTS The 24-h area under the plasma triacylglycerol curve after the test meal was lower after the low-fat diet than after the high-fat diet ( P < 0.04 ) . |
CONCLUSIONS African American and white women had lower fasting plasma total and LDL-cholesterol concentrations and less postprandial lipemia after the low-fat than the high-fat diet . |
CONCLUSIONS Diets low in total and saturated fat and cholesterol and high in fiber may reduce the risk of CHD by lowering fasting plasma total and LDL-cholesterol concentrations and by reducing the lipemic response to fatty meals . |
###23497763 |
BACKGROUND Mirabegron is a 3-adrenoceptor agonist used for the treatment of overactive bladder . |
BACKGROUND Mirabegron is formulated as an extended-release tablet using oral controlled-absorption system ( OCAS ) technology . |
OBJECTIVE This study was designed to assess the effects of food on the pharmacokinetic properties of mirabegron OCAS in accordance with regulatory requirements to support dosing recommendations . |
METHODS In this single-dose , randomized , open-label , 3-period , parallel-dose-group , crossover study , mirabegron OCAS 50 or 100 mg was administered orally to healthy adult subjects in the fasted state or after a high - or low-fat breakfast . |
METHODS Dose administrations were separated by a washout period of at least 10 days . |
METHODS Blood samples were drawn up to 96 hours after dosing , and plasma concentrations of mirabegron were analyzed by LC/MS-MS . |
METHODS PK properties were determined using noncompartmental methods . |
METHODS Primary end points for the assessment of food effects were Cmax and AUC0 - . |
METHODS For tolerability assessment , adverse events ( AEs ) were monitored using investigators ' questionnaires and subjects ' spontaneous reports , vital sign measurements , hematology , clinical chemistry , and ECG . |
RESULTS Thirty-eight subjects ( male , 50 % ; mean age , 32.1 years ; mean weight , 77.3 kg ; race , 76.3 % white ) were enrolled in the 50-mg dose group and 38 subjects ( male , 52.6 % ; mean age , 30.9 years ; mean weight , 74.5 kg ; race , 63.2 % white ) in the 100-mg dose group . |
RESULTS With either fed condition or dose , the 90 % CIs for the fed/fasted ratios of both Cmax and AUC0 - of mirabegron fell below the predetermined range for bioequivalence ( 80.0 % -125.0 % ) , suggesting that food had no effect on exposure to mirabegron OCAS . |