tner/bionlp2004 · Datasets at Hugging Face

tokens sequence	tags sequence
[ "Retinoic", "acid", "(", "RA", ")", ",", "a", "vitamin", "A", "derivative", ",", "exerts", "a", "wide", "range", "of", "biological", "effects", "related", "to", "cell", "proliferation", "and", "differentiation", "." ]	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
[ "The", "pleiotropic", "effects", "of", "RA", "are", "thought", "to", "be", "mediated", "through", "specific", "nuclear", "RA", "receptors", "(", "RARs", ")", "." ]	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 0, 3, 0, 0 ]
[ "RARs", "are", "members", "of", "the", "steroid/thyroid", "hormone", "receptor", "superfamily", "and", "exhibit", "a", "molecular", "structure", "that", "possess", "discrete", "DNA-binding", "and", "RA", "(", "ligand", ")", "-binding", "domains", "." ]	[ 3, 0, 0, 0, 0, 3, 4, 4, 4, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 4, 4, 4, 4, 0 ]
[ "In", "hematopoietic", "system", ",", "RA", "and", "RARs", ",", "predominantly", "RAR", "alpha", "may", "play", "key", "roles", "for", "the", "proliferation", "and", "differentiation", "of", "hematopoietic", "progenitors", "." ]	[ 0, 0, 0, 0, 0, 0, 3, 0, 0, 3, 4, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 0 ]
[ "However", ",", "it", "is", "currently", "unknown", "how", "RA", "and", "RARs", "are", "involved", "in", "regulating", "normal", "hematopoietic", "differentiation", "." ]	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 0, 0, 0, 0, 0, 0, 0, 0 ]
[ "To", "make", "clear", "the", "roles", "of", "RA", "and", "RAR", "alpha", "in", "the", "normal", "hematopoiesis", ",", "I", "have", "introduced", "the", "construct", "of", "human", "RAR", "alpha", "(", "hRAR", "alpha", ")", "into", "murine", "bone", "marrow", "cells", "with", "retroviral", "vector", ",", "and", "selected", "infected", "cells", "with", "drug", "resistant", "marker", "(", "Neo", "(", "r", ")", ")", "cultured", "on", "the", "stroma", "cell", "line", "(", "PA6-neo", ")", ",", "and", "analyzed", "the", "behavior", "of", "infected", "cells", "." ]	[ 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 4, 0, 3, 4, 0, 0, 5, 6, 6, 6, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0, 1, 2, 2, 2, 0, 0, 0, 0, 7, 8, 8, 0, 7, 0, 0, 0, 0, 0, 0, 0, 5, 6, 0 ]
[ "All", "of", "procedure", "were", "done", "in", "vitro", "." ]	[ 0, 0, 0, 0, 0, 0, 0, 0 ]
[ "Most", "cells", "infected", "with", "hRAR", "alpha", "exhibited", "promyelocytic", "morphology", "and", "were", "thought", "to", "be", "blocked", "at", "the", "promyelocytic", "stage", "in", "their", "myeloid", "differentiation", "." ]	[ 0, 0, 0, 0, 3, 4, 0, 5, 6, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
[ "Furthermore", ",", "these", "immature", "cells", "differentiated", "terminally", "into", "mature", "granulocytes", "by", "adding", "with", "RA", "(", "10", "(", "-6", ")", "M", ")", "." ]	[ 0, 0, 0, 5, 6, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
[ "RAR", "alpha", "infected", "cells", "were", "also", "able", "to", "differentiate", "into", "mature", "macrophages", "in", "the", "both", "of", "long", "term", "culture", "and", "IL3", "colony", "." ]	[ 3, 4, 5, 6, 0, 0, 0, 0, 0, 0, 5, 6, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0 ]
[ "These", "observations", "suggest", "that", "an", "overexpression", "of", "RAR", "alpha", "alone", "is", "effective", "to", "suppress", "myeloid", "cell", "differentiation", "and", "RAR", "alpha", "plays", "a", "crucial", "role", "in", "the", "terminal", "differentiation", "of", "myeloid", "precursors", "." ]	[ 0, 0, 0, 0, 0, 0, 0, 3, 4, 0, 0, 0, 0, 0, 5, 6, 0, 0, 3, 4, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
[ "The", "system", "described", "here", "may", "serve", "as", "a", "model", "for", "studying", "the", "the", "essential", "genes", "for", "differentiation", "of", "normal", "bone", "marrow", "cells", "." ]	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 5, 6, 6, 6, 0 ]
[ "Hypoxic", "induction", "of", "interleukin-8", "gene", "expression", "in", "human", "endothelial", "cells", "." ]	[ 0, 0, 0, 1, 2, 0, 0, 5, 6, 6, 0 ]
[ "Because", "leukocyte-mediated", "tissue", "damage", "is", "an", "important", "component", "of", "the", "pathologic", "picture", "in", "ischemia/reperfusion", ",", "we", "have", "sought", "mechanisms", "by", "which", "PMNs", "are", "directed", "into", "hypoxic", "tissue", "." ]	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 0, 0, 0, 0, 0, 0 ]
[ "Incubation", "of", "human", "endothelial", "cells", "(", "ECs", ")", "in", "hypoxia", ",", "PO2", "approximately", "14-18", "Torr", ",", "led", "to", "time-dependent", "release", "of", "IL-8", "antigen", "into", "the", "conditioned", "medium", ";", "this", "was", "accompanied", "by", "increased", "chemotactic", "activity", "for", "PMNs", ",", "blocked", "by", "antibody", "to", "IL-8", "." ]	[ 0, 0, 5, 6, 6, 0, 5, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 0, 0, 0, 0, 0, 3, 0 ]
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[ "In", "mice", "exposed", "to", "hypoxia", "(", "PO2", "approximately", "30-40", "Torr", ")", ",", "there", "was", "increased", "pulmonary", "leukostasis", ",", "as", "evidenced", "by", "increased", "myeloperoxidase", "activity", "in", "tissue", "homogenates", "." ]	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 0, 0, 0, 0, 0 ]
[ "In", "parallel", ",", "increased", "levels", "of", "transcripts", "for", "IP-10", ",", "a", "murine", "homologue", "in", "the", "chemokine", "family", "related", "to", "IL-8", ",", "were", "observed", "in", "hypoxic", "lung", "tissue", "." ]	[ 0, 0, 0, 0, 0, 0, 0, 0, 3, 0, 0, 0, 0, 0, 0, 3, 4, 0, 0, 3, 0, 0, 0, 0, 0, 0, 0, 0 ]
[ "Taken", "together", ",", "these", "data", "suggest", "that", "hypoxia", "constitutes", "a", "stimulus", "for", "leukocyte", "chemotaxis", "and", "tissue", "leukostasis", "." ]	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
[ "Thrombin", "and", "thrombin", "receptor", "agonist", "peptide", "induce", "early", "events", "of", "T", "cell", "activation", "and", "synergize", "with", "TCR", "cross-linking", "for", "CD69", "expression", "and", "interleukin", "2", "production", "." ]	[ 3, 0, 3, 4, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 0, 0, 3, 0, 0, 0, 0, 0, 0 ]
[ "Thrombin", "stimulation", "of", "the", "T", "leukemic", "cell", "line", "Jurkat", "induced", "a", "transient", "increase", "in", "[", "Ca2+", "]", "i", "." ]	[ 3, 0, 0, 0, 7, 8, 8, 8, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
[ "Proteolytic", "activity", "of", "the", "enzyme", "was", "required", "for", "this", "effect", "since", "diisopropyl", "fluorophosphate-thrombin", "failed", "to", "increase", "[", "Ca2+", "]", "i", "." ]	[ 0, 0, 0, 0, 3, 0, 0, 0, 0, 0, 0, 3, 4, 0, 0, 0, 0, 0, 0, 0, 0 ]
[ "Furthermore", ",", "hirudin", "and", "anti-thrombin", "III", "inhibited", "the", "thrombin-induced", "[", "Ca2+", "]", "i", "rise", "in", "Jurkat", "T", "cells", "." ]	[ 0, 0, 0, 0, 3, 4, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 8, 0 ]
[ "A", "synthetic", "thrombin", "receptor", "agonist", "peptide", "(", "TRP", ")", "of", "7", "residues", "(", "SFLLRNP", ")", "was", "found", "to", "be", "as", "effective", "as", "thrombin", "for", "[", "Ca2+", "]", "i", "mobilization", ",", "and", "both", "agonists", "induced", "Ca2+", "release", "exclusively", "from", "internal", "stores", "." ]	[ 0, 0, 3, 4, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
[ "Thrombin", "stimulated", "tyrosine", "phosphorylation", "of", "several", "proteins", "of", "molecular", "mass", "40", ",", "42", ",", "70", ",", "120", ",", "and", "130", "kDa", "." ]	[ 3, 0, 0, 0, 0, 0, 0, 0, 3, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4, 0 ]
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[ "Thrombin", "and", "TRP", "also", "caused", "translocation", "of", "protein", "kinase", "C", "from", "the", "cytosol", "to", "the", "plasma", "membrane", "." ]	[ 3, 0, 0, 0, 0, 0, 0, 3, 4, 4, 0, 0, 0, 0, 0, 0, 0, 0 ]
[ "As", "a", "likely", "consequence", "of", "these", "events", ",", "thrombin", "activated", "the", "nuclear", "factor", "NF-kB", "." ]	[ 0, 0, 0, 0, 0, 0, 0, 0, 3, 0, 0, 3, 4, 4, 0 ]
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[ "Stress", "response", "of", "senescent", "T", "lymphocytes", ":", "reduced", "hsp70", "is", "independent", "of", "the", "proliferative", "block", "." ]	[ 0, 0, 0, 5, 6, 6, 0, 0, 3, 0, 0, 0, 0, 0, 0, 0 ]
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