tner/bionlp2004 · Datasets at Hugging Face

tokens sequence	tags sequence
[ "However", ",", "activation", "from", "a", "remote", "position", "could", "only", "be", "achieved", "with", "the", "C-terminus", "of", "Oct-2a", "in", "B", "cells", "." ]	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 0, 3, 0, 5, 6, 0 ]
[ "In", "lymphoid", "cells", ",", "higher", "activation", "levels", "were", "observed", ",", "suggesting", "that", "distinct", "B-cell-specific", "cofactors", "in", "concert", "with", "the", "effector", "domains", "of", "Oct-2a", "might", "be", "involved", "in", "mediating", "transcription", "from", "proximal", "and", "remote", "positions", "." ]	[ 0, 5, 6, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 0, 0, 0, 0, 3, 4, 0, 3, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
[ "Furthermore", ",", "we", "identified", "a", "repression", "domain", "at", "the", "N-terminus", "of", "Oct-2a", "." ]	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 0 ]
[ "When", "transferred", "to", "a", "potent", "activator", ",", "transcriptional", "stimulation", "was", "inhibited", "efficiently", "." ]	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
[ "These", "results", "underscore", "the", "modular", "structure", "of", "Oct-2a", "with", "separable", "domains", "for", "activation", "and", "repression", "and", "suggest", "that", "Oct-2a", "might", "have", "complex", "regulatory", "functions", "in", "vivo", "." ]	[ 0, 0, 0, 0, 0, 0, 0, 3, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 0, 0, 0, 0, 0, 0, 0, 0 ]
[ "Nonopsonic", "phagocytosis", "of", "Pseudomonas", "aeruginosa", "by", "macrophages", "and", "polymorphonuclear", "leukocytes", "requires", "the", "presence", "of", "the", "bacterial", "flagellum", "." ]	[ 0, 0, 0, 0, 0, 0, 5, 0, 5, 6, 0, 0, 0, 0, 0, 0, 0, 0 ]
[ "Whereas", "the", "mechanism", "of", "nonopsonic", "phagocytosis", "of", "Pseudomonas", "aeruginosa", "has", "been", "described", ",", "the", "bacterial", "ligands", "required", "are", "poorly", "understood", "." ]	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
[ "To", "identify", "the", "requisite", "bacterial", "ligands", ",", "studies", "with", "isogenic", "mutants", "of", "P.", "aeruginosa", "PAK", "lacking", "pili", ",", "flagella", ",", "and", "the", "RpoN", "sigma", "factor", "were", "undertaken", "." ]	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 4, 0, 0, 0 ]
[ "The", "RpoN", "mutant", ",", "lacking", "pili", ",", "flagella", ",", "and", "nonpilus", "adhesins", ",", "bound", "poorly", "and", "was", "resistant", "to", "ingestion", "by", "both", "macrophages", "and", "neutrophils", "." ]	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 0, 5, 0 ]
[ "Pili", "were", "not", "absolutely", "required", "for", "binding", "or", "phagocytosis", "of", "P.", "aeruginosa", "." ]	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
[ "The", "presence", "of", "a", "flagellum", "was", "not", "required", "for", "binding", "of", "P.", "aeruginosa", "to", "macrophages", "but", "was", "critical", "for", "the", "subsequent", "internalization", "of", "the", "bacterium", ",", "suggesting", "that", "this", "factor", "or", "a", "surface", "ligand", "associated", "with", "its", "assembly", "was", "responsible", "for", "stimulation", "of", "nonopsonic", "phagocytosis", "." ]	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
[ "Identification", "of", "essential", "GATA", "and", "Ets", "binding", "motifs", "within", "the", "promoter", "of", "the", "platelet", "glycoprotein", "Ib", "alpha", "gene", "." ]	[ 0, 0, 0, 1, 0, 1, 2, 2, 0, 0, 0, 0, 0, 1, 2, 2, 2, 2, 0 ]
[ "Platelet", "glycoprotein", "(", "GP", ")", "Ib-IX-V", "is", "a", "multisubunit", "adhesion", "receptor", "that", "supports", "platelet", "attachment", "to", "thrombogenic", "surfaces", "at", "sites", "of", "vascular", "injury", "." ]	[ 3, 4, 0, 3, 0, 3, 0, 0, 3, 4, 4, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
[ "The", "congenital", "absence", "of", "the", "receptor", "results", "in", "a", "bleeding", "disorder", "associated", "with", "``", "giant", "''", "platelets", ",", "a", "condition", "linking", "the", "expression", "of", "the", "complex", "to", "platelet", "morphogenesis", "." ]	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 6, 6, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
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[ "GP", "Ib", "alpha", "promoter", "activity", "was", "evaluated", "by", "transfection", "of", "human", "erythroleukemia", "cells", "with", "reporter", "plasmids", "coding", "for", "the", "enzyme", ",", "luciferase", "." ]	[ 1, 2, 2, 2, 0, 0, 0, 0, 0, 0, 5, 6, 6, 0, 0, 0, 0, 0, 0, 3, 0, 3, 0 ]
[ "Studies", "were", "initiated", "with", "a", "fragment", "extending", "2", ",", "738", "nucleotides", "5", "'", "to", "the", "transcription", "start", "site", "and", "lead", "to", "the", "identification", "of", "253", "nucleotides", "retaining", "full", "promoter", "activity", "in", "human", "erythroleukemia", "cells", "." ]	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 6, 0 ]
[ "In", "cells", "of", "nonhematopoietic", "lineage", ",", "human", "endothelial", "and", "HeLa", "cells", ",", "the", "GP", "Ib", "alpha", "promoter", "activity", "was", "no", "greater", "than", "background", "levels", "obtained", "with", "promoterless", "constructs", "." ]	[ 0, 0, 0, 5, 6, 0, 5, 6, 0, 5, 6, 0, 0, 1, 2, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0 ]
[ "Gel", "shift", "assays", "and", "site-directed", "mutagenesis", "studies", "defined", "essential", "GATA", "and", "Ets", "binding", "motifs", "93", "and", "150", "nucleotides", "upstream", "of", "the", "transcription", "start", "site", ",", "a", "finding", "which", "further", "substantiates", "these", "elements", "as", "important", "determinants", "of", "megakaryocytic", "gene", "expression", "." ]	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 1, 2, 2, 1, 2, 2, 2, 2, 0, 0, 1, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
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[ "CD30", "ligation", "induces", "nuclear", "factor-kappa", "B", "activation", "in", "human", "T", "cell", "lines", "." ]	[ 3, 0, 0, 3, 4, 4, 0, 0, 7, 8, 8, 8, 0 ]
[ "CD30", "is", "a", "recently", "described", "member", "of", "the", "tumor", "necrosis", "factor/nerve", "growth", "factor", "receptor", "superfamily", "." ]	[ 3, 0, 0, 0, 0, 0, 0, 0, 3, 4, 4, 4, 4, 4, 4, 0 ]
[ "In", "this", "report", ",", "we", "show", "that", "following", "incubation", "of", "L540", "cells", "(", "Hodgkin", "'s", "disease-derived", ",", "T", "cell-like", ",", "CD30+", "cells", ")", "with", "the", "agonistic", "anti-CD30", "monoclonal", "antibodies", "(", "mAb", ")", "M44", "and", "M67", ",", "two", "nuclear", "factor", "(", "NF", ")", "-kappa", "B", "DNA", "binding", "activities", "were", "induced", "in", "nuclear", "extracts", ",", "as", "determined", "in", "gel", "retardation", "assays", "." ]	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 7, 8, 8, 8, 8, 8, 8, 8, 8, 0, 0, 0, 3, 4, 4, 4, 0, 3, 0, 3, 0, 3, 0, 0, 3, 4, 4, 4, 4, 4, 4, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
[ "The", "effect", "of", "the", "mAb", "towards", "NF-kappa", "B", "activation", "was", "rapid", ",", "as", "it", "occurred", "within", "20", "min", ",", "and", "was", "sustained", "for", "up", "to", "6", "h", "." ]	[ 0, 0, 0, 0, 3, 0, 3, 4, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
[ "By", "comparison", ",", "an", "isotype-matched", "antibody", "had", "no", "effect", "on", "NF-kappa", "B", "activation", "." ]	[ 0, 0, 0, 0, 3, 4, 0, 0, 0, 0, 3, 4, 0, 0 ]
[ "Moreover", ",", "in", "human", "T", "helper", "(", "Th", ")", "clones", "functionally", "characterized", "as", "being", "of", "the", "type", "0", ",", "type", "1", "and", "type", "2", "(", "28", "%", ",", "<", "1", "%", "und", "93", "%", "CD30+", ",", "respectively", ")", ",", "the", "extent", "of", "CD30", "-mediated", "NF-kappa", "B", "activation", "correlated", "with", "the", "proportion", "of", "CD30+", "cells", "." ]	[ 0, 0, 0, 7, 8, 8, 8, 8, 8, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 0, 3, 4, 0, 0, 0, 0, 0, 0, 7, 8, 0 ]
[ "In", "all", "cell", "lines", "investigated", ",", "the", "NF-kappa", "B", "complexes", "induced", "following", "CD30", "engagement", "were", "shown", "to", "contain", "p50", "NF-kappa", "B1", ",", "p65", "RelA", ",", "and", "possibly", "other", "transcription", "factors", "." ]	[ 0, 0, 0, 0, 0, 0, 0, 3, 4, 4, 0, 0, 3, 0, 0, 0, 0, 0, 3, 4, 4, 0, 3, 4, 0, 0, 0, 0, 3, 4, 0 ]
[ "Collectively", ",", "our", "results", "demonstrate", "that", "nuclear", "translocation", "and", "activation", "of", "NF-kappa", "B", "rank", "among", "the", "short-term", "cellular", "responses", "elicited", "following", "CD30", "ligation", "." ]	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 0, 0, 0, 0, 0, 0, 0, 0, 3, 0, 0 ]
[ "Pathogenesis", "of", "atherosclerosis", "." ]	[ 0, 0, 0, 0 ]
[ "The", "earliest", "lesion", "in", "the", "development", "of", "an", "atherosclerotic", "plaque", "is", "the", "fatty", "streak", "." ]	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
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[ "At", "least", "1", "major", "gene", "modulates", "the", "oxidation", "of", "LDL", "lipids", "and/or", "the", "biologic", "response", "to", "these", "lipids", "." ]	[ 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
[ "The", "inverse", "relation", "between", "high", "density", "lipoprotein", "(", "HDL", ")", "and", "atherosclerotic", "events", "may", "in", "part", "be", "due", "to", "enzymes", "associated", "with", "HDL", "that", "destroy", "the", "biologically", "active", "lipids", "generated", "in", "LDL", "." ]	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
[ "Estrogen", "and", "progesterone", "receptors", "in", "vernal", "keratoconjunctivitis", "." ]	[ 3, 0, 3, 4, 0, 0, 0, 0 ]
[ "PURPOSE", ":", "Sex-related", "influences", "have", "been", "implicated", "in", "the", "pathogenesis", "of", "vernal", "keratoconjunctivitis", "(", "VKC", ")", ",", "an", "allergic", "eosinophilic", "disease", "." ]	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
[ "METHODS", ":", "The", "authors", "evaluated", "tarsal", "and", "bulbar", "conjunctival", "biopsies", "from", "seven", "patients", "with", "severe", "and", "symptomatic", "VKC", "for", "the", "presence", "of", "estrogen", "and", "progesterone", "receptors", "by", "using", "monoclonal", "antibodies", "with", "a", "peroxidase-antiperoxidase", "technique", "." ]	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 0, 3, 4, 0, 0, 3, 4, 0, 0, 0, 0, 0 ]
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[ "CIITA", "activates", "the", "expression", "of", "MHC", "class", "II", "genes", "in", "mouse", "T", "cells", "." ]	[ 3, 0, 0, 0, 0, 1, 2, 2, 2, 0, 0, 0, 0, 0 ]
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