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What is a representation of Mary at the Crucifixion called?
a Stabat Mater
31,187
What entity is responsible for the Taramati Music Festival?
The state government
75,781
Regarding the monastic rules, the Buddha reminds his hearers that it is the spirit that what?
counts
6,725
Who founded a shopping mall reserved for the most elites of society?
Count Essen-Stenbock-Fermor
44,849
Who converted to Lutheranism and secularized the Prussian branch of the Teutonic Order?
Albert of Brandenburg-Ansbach
67,464
What is (are) Lactate dehydrogenase deficiency ?
Lactate dehydrogenase deficiency is a condition that affects how the body breaks down sugar to use as energy in cells, primarily muscle cells. There are two types of lactate dehydrogenase deficiency: lactate dehydrogenase A deficiency (sometimes called glycogen storage disease XI) and lactate dehydrogenase B deficiency. People with lactate dehydrogenase A deficiency experience fatigue, muscle pain, and cramps during exercise (exercise intolerance). People with lactate dehydrogenase B deficiency typically do not have symptoms. Lactate dehydrogenase A deficiency is caused by mutations in the LDHA gene. Lactate dehydrogenase B deficiency is caused by mutations in the LDHB gene. Both types are inherited in an autosomal recessive pattern.
110,591
What is a notable architectural feature of the basilica?
transept
23,433
What is Bern's ranking for the best quality of life?
the world’s top ten
17,149
To whom would you go to acquire the algorithms you'd use for the Joint Test Action Group procedures?
JTAG tool vendors
77,398
what research (or clinical trials) is being done for Mucolipidoses ?
The mission of the National Institute of Neurological Disorders and Stroke (NINDS) is to seek fundamental knowledge of the brain and nervous system and to use that knowledge to reduce the burden of neurological disease. Investigators are conducting studies to determine the effects of ML genetic mutations in various animal models of the disease. Studying the disease mechanisms in these models may allow scientists to develop treatments for people with an ML disorder.Clinical trials include a natural history of individuals with ML IV, to better understand the disease and identify potential outcomes, and longitudinal studies to better understand disease progression, assess current therapies, and identify potential treatments.
88,796
How many UNESCO World Heritage Sites is Portugal home to?
fifteen
5,860
What motto of the team Barcelona appealed to the Catalans?
'More than a club'
28,524
Why was "An Act for Liberty to Erect a Collegiate School" proposed?
to create an institution to train ministers and lay leadership for Connecticut
48,891
How many Green Standard Army soldiers were on the Qing side?
400,000
82,547
What to Galician's call themselves in their language?
galegos
59,002
What two business drive Bermuda's economy?
offshore insurance and reinsurance, and tourism
52,671
During what span of time did the Pala Empire thrive?
750–1174 CE
61,074
What are two types of new mandolins the Luthiers created?
mandolin-banjo and the electric mandolin
64,466
What is the Continental Strand consideres to be by most of Freemasonry?
Irregular
37,938
Which prime minister was appointed only one time?
Margaret Thatcher
9,826
What is (are) 47,XYY syndrome ?
47,XYY syndrome is characterized by an extra copy of the Y chromosome in each of a male's cells. Although males with this condition may be taller than average, this chromosomal change typically causes no unusual physical features. Most males with 47,XYY syndrome have normal sexual development and are able to father children. 47,XYY syndrome is associated with an increased risk of learning disabilities and delayed development of speech and language skills. Delayed development of motor skills (such as sitting and walking), weak muscle tone (hypotonia), hand tremors or other involuntary movements (motor tics), and behavioral and emotional difficulties are also possible. These characteristics vary widely among affected boys and men. A small percentage of males with 47,XYY syndrome are diagnosed with autistic spectrum disorders, which are developmental conditions that affect communication and social interaction.
93,572
What things come with each new degree in Freemasonry?
passwords, signs and grips
37,919
Which idea is known as the ability of a person to have opinions and beliefs that are defined confidently, consistent, and stable?
self-concept
30,821
What is the average income in the New York securities industry?
US$360,700
4,249
What fragments were the complete Saragossa Manuscripts now produced based on?
French-language
80,479
Who revised the Julian calendar?
Pope Gregory XIII
29,342
What are the treatments for 17 alpha-hydroxylase/17,20-lyase deficiency ?
These resources address the diagnosis or management of 17 alpha-hydroxylase/17,20-lyase deficiency: - Genetic Testing Registry: Deficiency of steroid 17-alpha-monooxygenase These resources from MedlinePlus offer information about the diagnosis and management of various health conditions: - Diagnostic Tests - Drug Therapy - Surgery and Rehabilitation - Genetic Counseling - Palliative Care
108,135
What London museum was named for an historic Queen of England and her Prince husband?
the Victoria and Albert Museum (for the applied arts)
47,151
How many bridges does Nanjing have over the Yangtze River?
five
17,003
How many people are affected by ADCY5-related dyskinesia ?
The prevalence of ADCY5-related dyskinesia is unknown. At least 50 affected individuals have been described in the medical literature.
104,077
What is (are) Drug Reactions ?
Most of the time, medicines make our lives better. They reduce aches and pains, fight infections, and control problems such as high blood pressure or diabetes. But medicines can also cause unwanted reactions. One problem is interactions, which may occur between - Two drugs, such as aspirin and blood thinners - Drugs and food, such as statins and grapefruit - Drugs and supplements, such as gingko and blood thinners - Drugs and diseases, such as aspirin and peptic ulcers Interactions can change the actions of one or both drugs. The drugs might not work, or you could get side effects. Side effects are unwanted effects caused by the drugs. Most are mild, such as a stomach aches or drowsiness, and go away after you stop taking the drug. Others can be more serious. Drug allergies are another type of reaction. They can be mild or life-threatening. Skin reactions, such as hives and rashes, are the most common type. Anaphylaxis, a serious allergic reaction, is more rare. When you start a new prescription or over-the-counter medication, make sure you understand how to take it correctly. Know which other medications and foods you need to avoid. Ask your health care provider or pharmacist if you have questions.
117,447
A clause like "in witness whereof" or "in faith whereof" typically signals what in a treaty?
The end
19,364
What game development company completely disagreed with Kotick's statements in The Times interview?
Bioware
62,378
What is it called when a ref is knocked out?
ref bump
43,011
What did Atkins claim the term house reflected?
the exclusive association of particular tracks with particular clubs and DJs
25,770
What are the symptoms of Dermoids of cornea ?
What are the signs and symptoms of Dermoids of cornea? The Human Phenotype Ontology provides the following list of signs and symptoms for Dermoids of cornea. If the information is available, the table below includes how often the symptom is seen in people with this condition. You can use the MedlinePlus Medical Dictionary to look up the definitions for these medical terms. Signs and Symptoms Approximate number of patients (when available) Opacification of the corneal stroma 90% Visual impairment 90% Abnormality of the pupil 50% Abnormality of the eye - X-linked inheritance - The Human Phenotype Ontology (HPO) has collected information on how often a sign or symptom occurs in a condition. Much of this information comes from Orphanet, a European rare disease database. The frequency of a sign or symptom is usually listed as a rough estimate of the percentage of patients who have that feature. The frequency may also be listed as a fraction. The first number of the fraction is how many people had the symptom, and the second number is the total number of people who were examined in one study. For example, a frequency of 25/25 means that in a study of 25 people all patients were found to have that symptom. Because these frequencies are based on a specific study, the fractions may be different if another group of patients are examined. Sometimes, no information on frequency is available. In these cases, the sign or symptom may be rare or common.
111,858
What are the symptoms of Goodpasture Syndrome ?
The symptoms of Goodpasture syndrome may initially include fatigue, nausea, vomiting, and weakness. The lungs are usually affected before or at the same time as the kidneys, and symptoms can include shortness of breath and coughing, sometimes with blood. The progression from initial symptoms to the lungs being affected may be very rapid. Symptoms that occur when the kidneys are affected include blood in the urine or foamy urine, swelling in the legs, and high blood pressure.
120,370
Who referred to culture as a cultivation of individuals?
Georg Simmel
59,960
Along with the emission peaks and vs. bands mechanisms, what other physical mechanism is used to define near-infrared?
water absorption
30,004
what research (or clinical trials) is being done for Leigh's Disease ?
The NINDS supports and encourages a broad range of basic and clinical research on neurogenetic disorders such as Leigh's disease. The goal of this research is to understand what causes these disorders and then to apply these findings to new ways to diagnose, treat, and prevent them.
88,816
Do you have information about Blood Sugar
Summary : Blood sugar, or glucose, is the main sugar found in your blood. It comes from the food you eat, and is your body's main source of energy. Your blood carries glucose to all of your body's cells to use for energy. Diabetes is a disease in which your blood sugar levels are too high. Over time, having too much glucose in your blood can cause serious problems. Even if you don't have diabetes, sometimes you may have problems with blood sugar that is too low or too high. Keeping a regular schedule of eating, activity, and taking any medicines you need can help. If you do have diabetes, it is very important to keep your blood sugar numbers in your target range. You may need to check your blood sugar several times each day. Your health care provider will also do a blood test called an A1C. It checks your average blood sugar level over the past three months. If your blood sugar is too high, you may need to take medicines and/or follow a special diet. NIH: National Institute of Diabetes and Digestive and Kidney Diseases
93,035
What's the name of the local ITV division?
Meridian
19,182
How high have the Alpine Ibex been sighted?
as high as 3,000 m (9,843 ft)
20,780
What causes Dihydrolipoamide dehydrogenase deficiency ?
What causes dihydrolipoamide dehydrogenase deficiency? Dihydrolipoamide dehydrogenase (DLD) deficiency is caused by changes (mutations) in the DLD gene. This gene gives the body instructions to make an enzyme called dihydrolipoamide dehydrogenase (DLD). DLD is one part of 3 different groups of enzymes that work together (enzyme complexes). These enzyme complexes are involved in breaking down amino acids commonly found in protein-rich foods, and in other reactions that help to convert energy from food into a form that our cells can use. Mutations in the DLD gene impair the function of DLD, preventing the 3 enzyme complexes from functioning properly. This causes a build-up of molecules that are normally broken down, which in turn leads to tissue damage, lactic acidosis and other chemical imbalances. The brain is especially sensitive to the buildup of molecules and lack of cellular energy, which is why there are neurological problems associated with DLD deficiency.
99,576
what research (or clinical trials) is being done for Dementia With Lewy Bodies ?
The National Institute of Neurological Disorders and Stroke (NINDS) and other institutes of the National Institutes of Health conduct research related to DLB in laboratories at the NIH and support additional research through grants to major medical institutions across the country. Much of this research focuses on searching for the genetic roots of DLB, exploring the molecular mechanisms of alpha-synuclein accumulation, and discovering how Lewy bodies cause the particular symptoms of DLB and the other synucleinopathies. The goal of NINDS research is to find better ways to prevent, treat, and ultimately cure disorders such as DLB.
115,164
What are the symptoms of Carpotarsal osteochondromatosis ?
What are the signs and symptoms of Carpotarsal osteochondromatosis? The Human Phenotype Ontology provides the following list of signs and symptoms for Carpotarsal osteochondromatosis. If the information is available, the table below includes how often the symptom is seen in people with this condition. You can use the MedlinePlus Medical Dictionary to look up the definitions for these medical terms. Signs and Symptoms Approximate number of patients (when available) Abnormality of the wrist 90% Multiple enchondromatosis 90% Tarsal synostosis 90% Autosomal dominant inheritance - Joint swelling - Osteochondroma - The Human Phenotype Ontology (HPO) has collected information on how often a sign or symptom occurs in a condition. Much of this information comes from Orphanet, a European rare disease database. The frequency of a sign or symptom is usually listed as a rough estimate of the percentage of patients who have that feature. The frequency may also be listed as a fraction. The first number of the fraction is how many people had the symptom, and the second number is the total number of people who were examined in one study. For example, a frequency of 25/25 means that in a study of 25 people all patients were found to have that symptom. Because these frequencies are based on a specific study, the fractions may be different if another group of patients are examined. Sometimes, no information on frequency is available. In these cases, the sign or symptom may be rare or common.
98,872
Is tubular aggregate myopathy inherited ?
Most cases of tubular aggregate myopathy, including those caused by STIM1 gene mutations, are inherited in an autosomal dominant pattern. Autosomal dominant inheritance means one copy of the altered gene in each cell is sufficient to cause the disorder. In some cases, the mutation is passed through generations in a family. Other cases result from new mutations in the gene and occur in people with no history of the disorder in their family. Rarely, tubular aggregate myopathy is inherited in an autosomal recessive pattern, which means both copies of a gene in each cell have mutations. The parents of an individual with an autosomal recessive condition each carry one copy of the mutated gene, but they typically do not show signs and symptoms of the condition. Researchers are still working to determine which gene or genes are associated with autosomal recessive tubular aggregate myopathy.
97,185
How many people are affected by succinyl-CoA:3-ketoacid CoA transferase deficiency ?
The prevalence of SCOT deficiency is unknown. More than 20 cases of this condition have been reported in the scientific literature.
108,312
What Italian territory did Yugoslavia acquire after the war?
Istria
19,712
A presidential candidate from what party derided the city for its liberalism?
Republican
4,013
What kind of relationship do some scholars believe exists between Isis and Mary?
iconographic
31,190
In what year was the toponym Schwyz first attested as Old High German Suittes?
972
50,928
How many islands are in the Tuvalu group?
nine islands
81,064
What are the symptoms of Heart Attack ?
Not all heart attacks begin with the sudden, crushing chest pain that often is shown on TV or in the movies. In one study, for example, one-third of the patients who had heart attacks had no chest pain. These patients were more likely to be older, female, or diabetic. The symptoms of a heart attack can vary from person to person. Some people can have few symptoms and are surprised to learn they've had a heart attack. If you've already had a heart attack, your symptoms may not be the same for another one. It is important for you to know the most common symptoms of a heart attack and also remember these facts: Heart attacks can start slowly and cause only mild pain or discomfort. Symptoms can be mild or more intense and sudden. Symptoms also may come and go over several hours. People who have high blood sugar (diabetes) may have no symptoms or very mild ones. The most common symptom, in both men and women, is chest pain or discomfort. Women are somewhat more likely to have shortness of breath, nausea and vomiting, unusual tiredness (sometimes for days), and pain in the back, shoulders, and jaw. Some people don't have symptoms at all. Heart attacks that occur without any symptoms or with very mild symptoms are called silent heart attacks. Most Common Symptoms The most common warning symptoms of a heart attack for both men and women are: Chest pain or discomfort.Most heart attacks involve discomfort in the center or left side of the chest. The discomfort usually lasts for more than a few minutes or goes away and comes back. It can feel like pressure, squeezing, fullness, or pain. It also can feel like heartburn or indigestion. The feeling can be mild or severe. Upper body discomfort.You may feel pain or discomfort in one or both arms, the back, shoulders, neck, jaw, or upper part of the stomach (above the belly button). Shortness of breath.This may be your only symptom, or it may occur before or along with chest pain or discomfort. It can occur when you are resting or doing a little bit of physical activity. The symptoms of angina (an-JI-nuh or AN-juh-nuh) can be similar to the symptoms of a heart attack. Angina is chest pain that occurs in people who have coronary heart disease, usually when they're active. Angina pain usually lasts for only a few minutes and goes away with rest. Chest pain or discomfort that doesn't go away or changes from its usual pattern (for example, occurs more often or while you're resting) can be a sign of a heart attack. All chest pain should be checked by a doctor. Other Common Signs and Symptoms Pay attention to these other possible symptoms of a heart attack: Breaking out in a cold sweat Feeling unusually tired for no reason, sometimes for days (especially if you are a woman) Nausea (feeling sick to the stomach) and vomiting Light-headedness or sudden dizziness Any sudden, new symptoms or a change in the pattern of symptoms you already have (for example, if your symptoms become stronger or last longer than usual) Not everyone having a heart attack has typical symptoms. If you've already had a heart attack, your symptoms may not be the same for another one. However, some people may have a pattern of symptoms that recur. The more signs and symptoms you have, the more likely it is that you're having a heart attack. Quick Action Can Save Your Life: Call 911 The signs and symptoms of a heart attack can develop suddenly. However, they also can develop slowlysometimes within hours, days, or weeks of a heart attack. Any time you think you might be having heart attack symptoms or a heart attack, don't ignore it or feel embarrassed to call for help. Call 911 for emergency medical care, even if you are not sure whether you're having a heart attack. Here's why: Acting fast can save your life. An ambulance is the best and safest way to get to the hospital. Emergency medical services (EMS) personnel can check how you are doing and start life-saving medicines and other treatments right away. People who arrive by ambulance often receive faster treatment at the hospital. The 911 operator or EMS technician can give you advice. You might be told to crush or chew an aspirin if you're not allergic, unless there is a medical reason for you not to take one. Aspirin taken during a heart attack can limit the damage to your heart and save your life. Every minute matters. Never delay calling 911 to take aspirin or do anything else you think might help.
116,846
Who tried to invade Egypt in the famous line-in-the-sand incident?
Antiochus IV Epiphanes
38,758
How many councillors choose the Lord Mayor?
six
11,622
What causes Autoimmune hemolytic anemia ?
What causes autoimmune hemolytic anemia? In about half of cases, the cause of autoimmune hemolytic anemia cannot be determined (idiopathic or primary). This condition can also be caused by or occur with another disorder (secondary) or rarely, occur following the use of certain drugs (such as penicillin) or after a person has a blood and marrow stem cell transplant. Secondary causes of autoimmune hemolytic anemia include: Autoimmune diseases, such as lupus Chronic lymphocytic leukemia Non-Hodgkin's lymphoma and other blood cancers Epstein-Barr virus Cytomegalovirus Mycoplasma pneumonia Hepatitis HIV
112,885
What was the purpose of this order?
to demonstrate the Navy's capability to extend to the global theater
29,719
Who established the Tibetan law code?
Tai Situ Changchub Gyaltsen
2,240
What is the last letter of nearly all CBC stations?
"T"
67,223
Along with aristocratic writers, where do contemporary written descriptions of peasants come from?
law codes
23,343
Who was the last president not to appoint a Chief of Staff?
Lyndon Johnson
85,986
Which economist is cited the most by winners of the Nobel prize in that field?
Kenneth Arrow
68,266
In what did the bagpipe fill an important role?
early classical music,
18,495
Who doesn’t believe that Joseph Stalin had plans to invade Germany?
David Glantz
53,612
What does Sure South Atlantic LTD offer?
television
14,415
What type of paper is produced on a machine like the Fourdrinier?
wove paper
16,046
Which Iranian scientist co-invented the first gas laser?
Ali Javan
79,547
Who where the ruling class after the revolutionary republic was created?
Protestant and British
79,700
Which British critic praised 'Duel'?
Dilys Powell
71,434
What professional did Bell make sure was present during the first Silver Dart flight?
a doctor
13,876
What are the genetic changes related to Donnai-Barrow syndrome ?
Mutations in the LRP2 gene cause Donnai-Barrow syndrome. The LRP2 gene provides instructions for making a protein called megalin, which functions as a receptor. Receptor proteins have specific sites into which certain other proteins, called ligands, fit like keys into locks. Together, ligands and their receptors trigger signals that affect cell development and function. Megalin has many ligands involved in various body processes, including the absorption of vitamins A and D, immune functioning, stress response, and the transport of fats in the bloodstream. Megalin is embedded in the membrane of cells that line the surfaces and cavities of the body (epithelial cells). The receptor helps move its ligands from the cell surface into the cell (endocytosis). It is active in the development and function of many parts of the body, including the brain and spinal cord (central nervous system), eyes, ears, lungs, intestine, reproductive system, and the small tubes in the kidneys where urine is formed (renal tubules). LRP2 gene mutations that cause Donnai-Barrow syndrome are believed to result in the absence of functional megalin protein. The lack of functional megalin in the renal tubules causes megalin's various ligands to be excreted in the urine rather than being absorbed back into the bloodstream. The features of Donnai-Barrow syndrome are probably caused by the inability of megalin to help absorb these ligands, disruption of biochemical signaling pathways, or other effects of the nonfunctional megalin protein. However, it is unclear how these abnormalities result in the specific signs and symptoms of the disorder. A condition previously classified as a separate disorder called facio-oculo-acoustico-renal (FOAR) syndrome has also been found to be caused by LRP2 mutations. FOAR syndrome is now considered to be the same disorder as Donnai-Barrow syndrome.
97,894
In what year did Southampton Container Terminals open?
1968
18,995
What is the purpose of a DBMS?
to allow the definition, creation, querying, update, and administration of databases
76,366
In its preparations, what was the source of other considerations by the ECHR?
the judgements of several international and municipal courts
1,186
How many years is the deal with Legendary Pictures intended to run?
five years
13,593
Which regime did Güshi Khan help establish?
the Ganden Phodrang
2,188
Why were Americans allowed to start checking more than one box to identify their race in the Census in 200?
Because more Americans have insisted on being allowed to acknowledge their mixed racial origins
36,252
When did BBC Japan begin broadcasting?
December 2004
11,286
What are the genetic changes related to autosomal dominant partial epilepsy with auditory features ?
Mutations in the LGI1 gene cause ADPEAF. This gene provides instructions for making a protein called Lgi1 or epitempin, which is found primarily in nerve cells (neurons) in the brain. Although researchers have proposed several functions for this protein, its precise role in the brain remains uncertain. Mutations in the LGI1 gene likely disrupt the function of epitempin. It is unclear how the altered protein leads to seizure activity in the brain. LGI1 mutations have been identified in about half of all families diagnosed with ADPEAF. In the remaining families, the cause of the condition is unknown. Researchers are searching for other genetic changes that may underlie the condition.
106,613
How many Irish employees did Dell hire?
4,500
34,993
What religion believes that all theist worship the same god?
Hinduism and Sikhism
63,323
What is (are) Vesicoureteral Reflux ?
The two types of VUR are primary and secondary. Most cases of VUR are primary and typically affect only one ureter and kidney. With primary VUR, a child is born with a ureter that did not grow long enough during the childs development in the womb. The valve formed by the ureter pressing against the bladder wall does not close properly, so urine refluxes from the bladder to the ureter and eventually to the kidney. This type of VUR can get better or disappear as a child gets older. As a child grows, the ureter gets longer and function of the valve improves. Secondary VUR occurs when a blockage in the urinary tract causes an increase in pressure and pushes urine back up into the ureters. Children with secondary VUR often have bilateral reflux. VUR caused by a physical defect typically results from an abnormal fold of tissue in the urethra that keeps urine from flowing freely out of the bladder. VUR is usually classified as grade I through V, with grade I being the least severe and grade V being the most severe.
119,233
When were the best biographies of Queen Victoria written?
1964 and 1972
37,457
The first Home Rule bill would have given Ireland less self-control than what other territory?
Canada
46,107
How were the recordings released for the initial five seasons?
as a compilation album
7,718
Were peopel in pre-industrial societies considered to have long or short lifespans?
short life expectancy
55,518
How to diagnose Hendra Virus Disease (HeV) ?
Laboratory tests that are used to diagnose Hendra virus (HV) and Nipah virus (NV) include detection of antibody by ELISA (IgG and IgM), real time polymerase chain reaction (RT-PCR), and virus isolation attempts. In most countries, handling Hendra virus needs to be done in high containment laboratories. Laboratory diagnosis of a patient with a clinical history of HV or NV can be made during the acute and convalescent phase of the disease by using a combination of tests including detection of antibody in the serum or the cerebrospinal fluid (CSF), viral RNA detection (RT-PCR) in the serum, CSF, or throat swabs, and virus isolation from the CSF or throat swabs.
118,972
Who catalyzed the conversion of Tajik script into Cyrillic?
the Soviet government
10,587
What is the most populous city in Texas?
Houston
26,454
Who won the presidential election in 2009?
Sassou
9,683
What type of wood was used on the inside ?
maple
71,655
On what island was the Bonaparte ancestral home located?
Corsica
38,935
Where was the radio station KMXB based in 1997?
Las Vegas
16,542
In binary fission, what shape is each genome?
circular
21,115
Did Austria get Silesia back?
Austria was not able to retake Silesia
70,451
What is (are) Liver Diseases ?
Your liver is the largest organ inside your body. It helps your body digest food, store energy, and remove poisons. There are many kinds of liver diseases. Viruses cause some of them, like hepatitis A, hepatitis B, and hepatitis C. Others can be the result of drugs, poisons or drinking too much alcohol. If the liver forms scar tissue because of an illness, it's called cirrhosis. Jaundice, or yellowing of the skin, can be one sign of liver disease. Cancer can affect the liver. You could also inherit a liver disease such as hemochromatosis. Tests such as imaging tests and liver function tests can check for liver damage and help to diagnose liver diseases.
117,417
What are the treatments for Paget's Disease of Bone ?
Yes. Some complications from Paget's disease respond well to surgery. Joint replacement may be helpful in people with severe arthritis of the hip or knee. Surgery can also realign affected leg bones to reduce pain or help broken bones heal in a better position.
118,731
who sang the hit single "vogue"?
Madonna
25,846
What is (are) Majeed syndrome ?
Majeed syndrome is characterized by recurrent episodes of fever and inflammation in the bones and skin. The two main features of this condition are chronic recurrent multifocal osteomyelitis (CRMO) and congenital dyserythropoietic anemia (CDA). CRMO causes recurrent episodes of pain and joint swelling which can lead to complications such as slow growth and the development of joint deformities called contractures. CDA involves a shortage of red blood cells which can lead to fatigue (tiredness), weakness, pale skin, and shortness of breath. Most people with Majeed syndrome also develop inflammatory disorders of the skin, most often a condition known as Sweet syndrome. Majeed syndrome results from mutations in the LPIN2 gene. This condition is inherited in an autosomal recessive pattern.
99,046