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After becoming the youngest player to score and attend a La Liga match and being the youngest footballer to score in Champions League, Fati can also become the youngest to debut in a Classic in the 21st century.
A week after becoming the youngest scorer in the history of the Champions League, Ansu Fati has a new record for targeting: being the youngest to debut in a Classic in the 21st century.
Until now, the record is held by Bojan Krkic, in December 2007, with 17 years and 117 days, he became the youngest footballer to play in a Classic in the 21st century, beating Lionel Messi, who debuted at 18 and 148 days. | https://www.e360hubs.com/2019/12/fati-could-become-youngest-player-to.html | 137 |
Dostoevsky research papers include research about his life and works such as Crime and Punishment.
Dostoevsky research papers can be on the Russian author himself or on his great works of world literature such as Crime and Punishment, The Brothers Karamazov and Notes from Underground. Have Paper Masters custom write a research paper on Dostoevsky and explicate his works for you in a custom paper.
It is virtually impossible to separate the works of Fyodor Dostoevsky from the events that influenced his life. The Russian Age of Enlightenment, the Paris Revolt of 1845, his membership in the Petrashevsky circle, and the rise of the Russian Serf toward emancipation were all events that greatly influenced his life and work. Prior to the later 19th Century, Russia had experienced an age of enlightenment. Under Catherine II, the government sponsored Russian Enlightenment, which included the principles of French Philosophy in the writings of Montesquieu, Voltaire and others. Enthusiasm for liberal ideas and education reached a new high in Russia. Government came under question, Labor was examined, and a national culture was formed. Russians became educated in the ways of government and began to understand that changes needed to be made in the fabric of the Russian economy and social structure.
Speaking openly about the ills of society, government and the human spirit, Dostoevsky pours his commentary on Russian life through the character of Raskolnikov. March 15th, 1845, during the Paris Revolt, Dostoevsky joined the Petrashevsky, a group of liberal thinking revolutionaries who encouraged the formation of political groups in Russia. Four years later he was arrested for treason while at a meeting of the Petrashevsky and he was imprisoned for five years. During these five years, Dostoevsky reflected heavily on the life and lot of Russian peasants and he related to the suffering they endured. The prostitute in Crime and Punishment is representative of the peasant class in Russia, a class that may not be morally or socially contrite, but are guiltless of their situation, just as the prostitute could do nothing to change hers. Crime and Punishment is a novel of reflection for Dostoevsky.
Enlightenment research papers report that the philosophies of the era were one of the causes of the French Revolution. Order a research paper on the Enlightenment from Paper Masters.
Catherine The Great And The Russian Nobility, author Paul Dukes expands on his doctoral dissertation to describe her relationships.
Montesquieu research papers overview the revolutionary writings of the French author and philosopher.
Character Sketch of The Brothers Karamazov research papers analyze each character in Dostoevsky's classic novel.
| https://www.papermasters.com/dostoevsky.html | 567 |
Another woman here. I would never, ever, ever agree to a guy (a complete stranger) following me around while I shop. Just thinking about that gives me the heebie jeebies. I would, however, totally give a complete stranger my number to text for a while and agree to meet up on my own terms if he seemed cool over text. If you’re getting nothing but rejection, you might be coming off as a little insincere which in turn is a little creepy. Try having a conversation with women without seeing them as the end goal of getting laid. Talk to them like you would any other man/human being without an agenda. Don’t think “I have to ask to follow her, so I can talk to her, so she can be comfortable giving me her number so we can.....” you’re already planning waaay too far ahead and we women can sense that and yes it is totally creepy. Instead go with the advice of giving a complement and seeing if you can strike up a conversation organically. It can be the shortest conversation ever. Once it starts to die just say would you want to go out sometime? If the answer is yes, the number exchanging will happen naturally. I think you’ll be pleasantly surprised. | 17d22183874043bcac16caf7461b5a09 | 265 |
Greetings from Santa Cruz Elementary School District 28 in Nogales, Arizona! We are a public school district with a passion for educating students in a caring and safe learning environment. Our school has a dedicated faculty and staff, a supportive community, and a student body we're proud of.
Thank you for your interest in Santa Cruz Elementary. We invite you to learn more about what makes us a great school.
Welcome to Little Red School, SCED 28, home of the mighty Mustang!
The school district of SCED 28 is committed to providing all students with quality, personalized learning that prepares students to meet current and future challenges. Our K–8 school has a "family-like" approach where every child receives personal attention; high quality education; numerous co-curricular opportunities within our after school sports and Friday program; and an academic culture where students, staff, parents, and the community value high achievement. It is our priority at Little Red to focus on each student individually; our teachers work extremely hard to improve achievement and to work on delivering curriculum in which all students can learn. No exceptions!
This year the district (and state) continues to implement Arizona College and Career Readiness Standards. The standards bring thinking skills to each subject. Society is changing rapidly, and simply knowing an answer isn't good enough. Students must be able to think and problem solve to develop their own solutions. It is our goal to develop students who have the ability to think critically, apply knowledge at high levels, and use technology to meet the current and future challenges in the 21st century.
We look forward to an exciting and productive year!
Our third quarter honor roll assembly was a huge success. Congratulations to all the students who have worked so hard this quarter!
Santa Cruz Elementary District #28 provides a safe learning environment with high expectations and academic success for everyone; the district empowers students to be confident, knowledgeable, responsible, and productive citizens in a diverse, ever-changing world. | 6fbcc9ec827fb06778fbae6ffdc7c7a5 | 402 |
Glenn A. Carter founded CSG International DP, Inc. Mr. Carter is on the board of Tyler Technologies, Inc.
Mr. Carter previously was Vice President-Market & Business Development at CSG Systems International, Inc. and Chief Executive Officer for CSG International DP, Inc. (a subsidiary of CSG Systems International, Inc.) and Principal at Xerox Corp.
Glenn A. Carter received an undergraduate degree from California Polytechnic State University (San Luis Obispo). | https://www.sb.marketwatch.com/investing/stock/TYL/insiders?pid=127039554 | 101 |
The AK Tuition has released the result of Maths Test August 2018 today at 12:30 pm. I am glad to see the performance of the first position student. But I am sorry to say that nobody has qualified for the reward kept for the topper. The reward was to be given to the student who would get 40% marks means 40 out of 50. | 5400e949032ac1836322427b074fc7f3 | 74 |
Water play is a great way to provide a natural sensory experience for kids. In this activity, they will mix coloured water and other ingredients to make "potions". It is a cheap and fun activity, perfect for playing with in hot weather.
Outdoor: This activity is best done outdoors.
Very cheap. Free if you have the items in your pantry.
1) First place the plastic containers and other items on the baking tray. This will help catch any unwanted spills.
2) Fill a container with a couple of tablespoons of bi-carb soda, another with about 40ml of white vinegar.
3) Fill the other containers with water and add a couple of drops of the food colouring, until you reach the desired colour.
4) Let the kids set about making their concoctions.
Aim: To have fun making pretend potions and introduce children to a concept of basic chemistry.
Time: 5 minutes to set up. This kept my 8 year old amused for an hour or so. Great frugal fun!
Players:1-2, for more kids add an extra tray with containers, water etc.
Why?: This is a good science lesson for introducing acids (vinegar) and bases (bi-carb.) When you add an acid to a base it results in a chemical reaction. Making the mixture bubble and fizz-just like a real potion!
Additions: You could substitute the 100's and 1000's for glitter, or add some dish liquid or bubble bath to the coloured water. Be creative.
Let the kids create their own potions!
Click here to find great places to visit with children. | http://kidfun.com.au/coloured-water-potions/ | 338 |
You set the variable “no_check_targets“ here and it was unused before it went out of scope.
I haven’t compiled a new version of CEF for a long time. Recently, chrome mentioned that there is a 23% performance improvement in version 91 https://blog.chromium.org/2021/05/chrome-is-faster-in-m91.html Is there such a big improvement?So I want to have a try. As a matter of course, I used my own script to compile. As a result, I encountered a “wonderful” problem. Here is a brief record.
Creating D:\google\cef_new\chromium\src\out\Debug_GN_x86 directory.
ERROR at //.gn:65:20: Assignment had no effect.
subprocess.CalledProcessError: Command '['D:\\google\\cef_new\\depot_tools\\python3.bat', 'D:\\google\\cef_new\\chromium\\src\\cef\\tools\\gclient_hook.py']' returned non-zero exit status 1.
No is defined in chromium. Src. GN_ check_ Targets, but not used. At first, I thought it was my own depot_ Tools version is wrong (I have many depots on my machine_ Tools), and then switch the various branches, commit or not. So, it’s better to add some logs in the python script to see what’s going on.
Hey, hey, hey?How did you get under electron?So that's the problem.
Microsoft.CppCommon.targets (132,5): how to solve error msb3073?
This entry was posted in How to Fix and tagged CEF on 2021-07-21 by Robins.
| https://programmerah.com/you-set-the-variable-no_check_targets-here-and-it-was-unused-before-it-went-out-of-scope-33373/ | 401 |
When I was in school, there was almost NO awareness of autism or Asperger's Syndrome.
My first job was working at a school for kids who had behavioral issues.
My son has social learning issues, so I had firsthand exposure to some of those difficulties.
I started working mostly with kids who had autism or Asperger's Syndrome.
I founded my own education center that teaches kids and adults social thinking skills.
I teach people with ADHD, Asperger's Syndrome and Autism how to be socially successful.
I spend my days working with kids and adults and teaching them executive function strategies and social thinking skills. The perfect day would include me hearing that what I taught someone helped them make a friend, get a job or helped them to be more socially competent.
I would honestly say that there's nothing that I learned in school that I use now. This field of work isn't something that you just fall into, and there definitely wasn't a great level of awareness of social learning issues (people who struggle with social skills) when I was going through college and graduate school, so I really had to seek this out on my own. You definitely need a willingness and desire to deeply learn about the issues you'll be working with.
Do some volunteer work to see if you like working with kids or adults who are diagnosed with Autism or Asperger's Syndrome. You probably know some already from your school.
"Don't you want to be a doctor or lawyer and make more money?"
In the culture I grew up in there was often a push to pursue a career that would yield the most income. It took me a while to find a career that was fulfilling to me, people always asked why didn't I want to be a doctor or a lawyer. I don't know that I ever fully "overcame" that noise; I was always second-guessing myself, until I finally realized that I've found a career that I love and that I'm good at, and nothing else matters.
My mother had multiple sclerosis when I was growing up. I learned at a young age that something unique about me was that I was very comfortable around people who had disabilities.
Dealing with my son's social learning issues inspired me to go from working with students with behavioral issues to working with students mostly dealing with autism and Asperger's Syndrome, and building a program that I have found to be effective. | https://roadtripnation.com/leader/syr/5a74b5c17ebc328bb0d4e5b5 | 495 |
This press release intends to inform readers that Binance, has stopped its users in the United Kingdom from withdrawing in Pound Sterlings.
According to a report from the Financial News, the embattled crypto exchange Binance has stopped allowing users in the United Kingdom to withdraw in Pound Sterlings.
The exchange has notified its subscribers of the latest situation through email. The cryptocurrency exchange had alleged problems with the Faster Payments Network (FPN), leaving its UK consumers without access to fiat cash withdrawals.
However, the exchange has been unable to provide any details about the current situation. Instead, it just announced that it was working on a solution and that it would notify its users once it had found one.
Clear Junction, a global payment provider, announced earlier this week that it will no longer offer its services to Binance for payments in Euro and Pounds. The payment solution allowed the CZ-led exchange to accept withdrawals and deposits from the Single Euro Payments Area (SEPA) and the Financial Payments Network (FPN).
In recent weeks, Binance has suffered a slew of issues. Various regulators throughout the world are scrutinizing the crypto exchange, claiming it does not have the legal authority to operate in their jurisdiction.
The warning provided by the Financial Conduct Authority of the United Kingdom, which indicated that the crypto platform had no authorization to operate in the country, influenced Clear Junction's decision. Other financial institutions in the country, like Barclays and others, began restricting transactions to Binance as a result of the warning.
The Dechained is an independent digital media resource that provides digestible blockchain news and information. Our team assists the next generation of investors in staying up to date on the latest industry news. To learn more about crypto and blockchain, as well as to be notified of important updates, subscribe to our newsletter, or visit https://www.thedechained.com/. | https://www.prfree.org/@thedechained/the-dechained-explains-why-binance-has-disabled-withdrawals-in-pound-sterling-for-its-uk-customers-6rm5r86nwkw4 | 380 |
Broad neutralization against SARS-CoV-2 variants induced by ancestral and B.1.351 AS03-Adjuvanted recombinant Plant-Derived Virus-Like particle vaccines
Since 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection resulting in the coronavirus disease 2019 (COVID-19) has afflicted hundreds of millions of people in a worldwide pandemic. Several safe and effective COVID-19 vaccines are now available. However, the rapid emergence of variants and risk of viral escape from vaccine-induced immunity emphasize the need to develop broadly protective vaccines. A recombinant plant-derived virus-like particle vaccine for the ancestral COVID-19 (CoVLP) recently authorized by Canadian Health Authorities and a modified CoVLP.B1351 targeting the B.1.351 variant (both formulated with the adjuvant AS03) were assessed in homologous and heterologous prime-boost regimen in mice. Both strategies induced strong and broadly cross-reactive neutralizing antibody (NAb) responses against several Variants of Concern (VOCs), including B.1.351/Beta, B.1.1.7/Alpha, P.1/Gamma, B.1.617.2/Delta and B.1.1.529/Omicron strains. The neutralizing antibody (NAb) response was robust with both primary vaccination strategies and tended to be higher for almost all VOCs following the heterologous prime-boost regimen.
Introduction
Since the declaration of a pandemic situation caused by the SARS-CoV-2 by the World Health Organisation (WHO), over 410 million cases have been reported and >5.8 million people have died from COVID-19 (WHO Coronavirus Disease (COVID-19) Dashboard, https://covid19.who.int/, 2021). The rapid development and approval of vaccines with efficacy up to 95% led to hope in mid-2021 that the worst of the pandemic was over [1][2][3][4]. However, the total number of COVID-19 cases is still growing rapidly worldwide with almost 300 000 reported deaths in just the last month, mostly attributable to highly transmissible SARS-CoV-2 Variants of Concern (VOCs). The most worrisome variants are those with mutations in the Spike (S) protein that not only enhance transmissibility but also increase virulence and evasion of vaccine-induced immunity [5][6][7][8][9][10] or resistance to neutralization by monoclonal antibodies [8,9,11]. The S protein plays a crucial role in SARS-CoV-2 infection through the interaction of its receptor binding domain (RBD) with the angiotensin-converting enzyme 2 (ACE2) receptor on host respiratory epithelial cells [12][13][14]. All of the currently approved vaccines target the S protein of the ancestral strain of SARS-CoV-2 identified in Wuhan and a growing number of reports demonstrate that their efficacy against mainly the B.1.351 and the B.1.617.2 variants is reduced [15][16][17][18]. Medicago has developed a SARS-CoV-2 vaccine using a platform technology based on transient expression of recombinant proteins in non-transgenic Nicotiana benthamiana plants and a disarmed Agrobacterium tumefaciens as a transfer vector to move targeted DNA constructs into the plant cells [19]. The S protein trimers displayed on the surface of the plant-derived coronavirus-like particles (CoVLP) are in a stabilized, prefusion conformation that resemble native structures on wild-type SARS-CoV-2 virions. Plant-based VLP vaccines are an emerging production platform that has many potential advantages such as proper eukaryotic protein modification and assembly, low risk of contamination with adventitious agents, scalability, and rapid production speed [20]. Currently, several plant-based VLP vaccine candidates against pathogens such as Hepatitis B virus [21], Rabies virus [22], Influenza virus [23] and Norwalk virus [24] are under clinical development. At the time of writing, only two plant-based VLP vaccine candidates against SARS-CoV-2 have reached the clinical stage; Medicago's CoVLP has completed its primary vaccine efficacy analyses in Phase 3 (NCT04636697) and has recently been authorized by Canadian Health Authorities [25] and Kentucky Bioprocessing-201 is in Phase 1/2 (NCT04473690). Herein, we present the preclinical evaluation of a CoVLP candidate targeting the B.1.351 variant compared with the original CoVLP targeting the ancestral SARS-CoV-2 strain, both of which were formulated with AS03, an Adjuvant System containing DL-a-tocopherol and squalene in an oil-in-water emulsion. Both homologous and heterologous primary immunization strategies induced strong neutralizing antibody (NAb) responses with broad cross-reactivity against the B. [19]. The S protein was modified at the S1/ S2 cleavage site (CoVLP: R667G, R668S and R670S substitutions; CoVLP.B1351: R682G, R683S and R685S substitutions; relative to native S protein from original B strain from EPI_ISL_406036) to increase stability and to stabilize the protein prefusion conformation (CoVLP: and K971P and V972P substitutions; CoVLP.B1351: K986P and V987P; relative to native S protein from original B strain from EPI_ISL_406036). The signal peptide was replaced with a plant gene signal peptide and the transmembrane domain (TM) and cytoplasmic tail (CT) of S protein were also replaced with TM/CT from Influenza H5 A/Indonesia/5/2005 to increase VLP assembly and budding. The self-assembled VLPs bearing S protein trimers were isolated from the plant matrix and subsequently purified using a process similar to that described for Medicago's plant-derived influenza VLP vaccine candidates [26].
The AS03 Adjuvant System, an oil-in-water emulsion containing 11.86 mg DL-a-tocopherol, 10.69 mg squalene and 4.86 mg Polysorbate 80 per adult human dose, was supplied by GSK, (Rixensart, Belgium) and was used as recommended by the manufacturer. The control article was phosphate buffered saline (PBS) solution with Polysorbate 80. On each dosing day, CoVLP and CoVLP.B1351 were diluted with PBS to achieve the appropriate concentration and then mixed in a 1:1 (volume:volume) ratio with adjuvant prior to administration.
Animals, immunizations and In-Life/Post-Mortem observations
Female specific pathogen free BALB/c mice (8 weeks old) were supplied from Charles River (St-Constant, Québec, Canada) and the study was conducted at ITR Laboratories Canada Inc (Baie d'Urfe, Quebec, Canada). The study protocol was approved by ITR's internal Animal Care Committee (ACC) and all animals used were cared for in accordance with the principles outlined in the current ''Guide to the Care and Use of Experimental Animals" published by the Canadian Council on Animal Care, the NIH's ''Guide for the Care and Use of Laboratory Animals" and the Animal Research Reporting In Vivo Experiments guidance. In summary, animals were maintained under standard laboratory conditions (lighting: 12 / 12 h, temperature: 21 ± 3°C, relative humidity: 50 ± 20%) with certified rodents pellet feed and drinking water ad libitum. The mice (8/group, except for no vaccine control; 5/group) were immunized intramuscularly (IM) with 3.75 lg AS03-adjuvanted CoVLP or CoVLP.B1351 or the PBS control on Days 0 and 21 (final volume 0.1 mL; 0.05 mL per injection site). The administered dose was calculated based on the total protein content (measured by the BCA method) and adjusted for the purity of the CoVLP content. The purity is based on the relative abundance of the S protein measured by reduced SDS-PAGE and densitometry analyses. The purity of CoVLP and CoVLP.B1351 were 81% and 80% respectively. The AS03adjuvanted vaccines were administered as either a homologous (CoVLP-CoVLP or CoVLP.B1351-CoVLP.B1351) or heterologous (CoVLP-CoVLP.B1351) prime-boost during primary vaccination ( Fig. 1). Mortality, clinical signs, body weight, food consumption and injection site observations were evaluated throughout the study. Macroscopic observations were performed at euthanasia on Day 35. Blood was collected on Days 0 (pre-immune), 21 and 35 to measure serum NAb levels.
Pseudovirus neutralization assay (PNA)
The PNA was performed by Nexelis (Laval, Quebec, Canada) using a pseudovirus based on SARS-CoV-2 ancestral Wuhan strain (reference MN908947) as previously described [27]. Analyses were performed in duplicate and included appropriate controls. The assay was qualified for the ancestral pseudovirus strain. Crossreactivity was evaluated using modified pseudovirions expressing SARS-CoV-2 S glycoproteins from representative B. In brief, serum samples were heat-inactivated at 56 ± 2°C for 30 min and diluted in duplicates in cell growth media at a starting dilution of 1/25 or 1/250, followed by a serial dilution (2-fold dilutions, 5 times). A previously pre-determined concentration of pseudovirus was then added to diluted sera samples and pre-incubated for 1 h at 37°C with CO 2 . The mixture was then added to pre-seeded confluent Vero E6 cells expressing the ACE2 receptor (ATCC CRL-1586) and incubated for 18-24 h at 37°C with 5% CO 2 . Following incubation and removal of media, ONE-Glo EX Luciferase Assay Substrate (Promega, Madison, WI) was added to cells and incubated for 3 min at room temperature with shaking. Luminescence was measured using a SpectraMax i3x microplate reader (Molecular Devices, San Jose, CA). A titration curve was generated based on a 4-parameter logistic regression (4PL) using Microsoft Excel. The NAb titer was defined as the reciprocal of the sample dilution for which the luminescence was equal to a pre-determined cut-point value corresponding to 50 % neutralization. Responders were considered positive if the NAb titer was 25. NAb results presented in the current study were obtained using pseudotyped SARS-CoV-2 virus. Note that results obtained with PNA generally correlates with live virus based microneutralization assay [28].
Statistical analyses
The descriptive statistics and statistical comparisons were performed using GraphPad Prism software (Version 8.4.2; GraphPad Prism Software, La Jolla, CA, USA). The geometric mean titers (GMT) of NAb titers with 95 % confidence intervals (CI) and percentage of positive responders were calculated for each group of mice. A titer value of 12.5 was attributed to titers lower than the minimum required dilution (MRD) (i.e., 1/25). Statistical comparisons to evaluate differences between groups were performed using either a one-way ANOVA followed by a Tukey post hoc test, or a two-way ANOVA followed by a Bonferroni post hoc test on log 10 -transformed antibody titers. Wilcoxon matched-pairs signed rank was used to assess differences between the various SARS-CoV-2 pseudovirus strains. The threshold for statistical significance was set to p < 0.05.
Neutralizing and Cross-Reactive antibodies induced by AS03-Adjuvanted CoVLP and CoVLP.B1351 following homologous Prime-Boost primary vaccination strategies
In this study, mice were immunized following either a homologous or heterologous prime-boost regimen with AS03-adjuvanted CoVLP and/or CoVLP.B1351 (Fig. 1) (Fig. 2A). All animals in the CoVLP and CoVLP.1351 groups respectively mounted a response above the MRD after the first dose. Cross-reactivity was also observed (Fig. 2B)
Heterologous Prime-Boost vaccination also induced a strong and Cross-Reactive antibody response to VOCs
The heterologous, AS03-adjuvanted CoVLP-CoVLP.B1351 vaccination also successfully induced high titers of NAbs against both strains included in the regimen as well as the other VOCs tested (Fig. 3), with the exception of the B.1.1.529 variant, for which NAb levels were 12-15 folds lower compared to the ancestral and the B.1.351 strains. Compared to the AS03-adjuvanted CoVLP-CoVLP group, the heterologous prime-boost group induced a significantly greater cross-reactive response for the B.1.351 (Fig. 3B) and P.1 (Fig. 3D) VOCs (p < 0.05). Compared to the CoVLP.B1351-CoVLP.B1351 homologous regimen, only the response against the ancestral strain was higher in the heterolo-
Safety of CoVLP and CoVLP.B1351 vaccines in animals
Overall, no safety concerns were raised following homologous prime-boost strategies or the heterologous strategy. The post-immunization variations observed for body weight and food consumption were transient and/or within the normal variations ( Figures S1 and S2). An unexpected increase in food consumption was observed in the CoVLP + AS03 group between Days 7-14 that was likely attributable to eating-like behavior (i.e. stashing of food pellets at the bottom of the cage) in a small number of the animals in this group. Transient signs of discomfort (Table S1) and inflammation at the dosing sites (edema and erythema) were reported in all treated groups following the prime ( Figure S3). All observations generally subsided within 10-14 days and were no longer seen prior to the second administration. After the second administration, no signs of reactogenicity or discomfort were reported at the injection site. No macroscopic anomalies were reported following euthanasia and collection of organs and tissues.
Discussion and conclusions
The first anti-COVID-19 vaccines were approved for emergency use within a year of the start of the pandemic with reported efficacies ranging from 50 to 95% [29]. Simultaneously however, multiple viral variants have emerged in different geographic regions with varied transmissibility, virulence and resistance to vaccine-induced immunity [30][31][32][33][34][35]. Many parts of the world have experienced rapid replacement of the ancestral Wuhan-like strain with one or a sequence of these variants of concern ''VOCs". The different waves of variants has complicated diagnostic efforts in some cases [8,9,36] and generally frustrated efforts to control the spread and impact of the pandemic [37]. Among the most important VOCs that have emerged over the last year include the B. [42,43] and it is estimated that the transmission rate of the recent B.1.1.529 variant is at least 4-times higher than the ancestral strain [44]. Several lines of evidence including animal models and epidemiological observations suggest that this increased transmissibility is related to Spike protein mutations [45,46] such as D614G [47,48], P681R [49] or K417N/E484K/ N501Y [50]. These mutations have significant functional effects related to transmissibility such as accelerated cell-to-cell spread [49] and the generation of higher virus loads in the upper airways when compared to the B.1.1.7 strain [42]. Although the relationship between different mutations and disease severity is not yet fully understood [51], recent evidence suggests that the B.1.1.7 variant is associated with a higher risk of emergency care consultation and hospital admission for unvaccinated individuals compared with B.1.1.7 variants [35]. It is very clear however that some of these mutations can confer significant resistance to antibody neutralization in vitro, particularly those present in the B. [5,11,18,58,59]. In several randomized controlled trials with different vaccines, efficacy against the B.1.351 variant was observed to fall by 33-84% [15][16][17]60] Although most of the deployed vaccines continue to have good efficacy against severe disease induced by most of the VOCs identified to date [15,61] and there is evidence of convergent evolution [62,63], it is unlikely that SARS-CoV-2 has fully exhausted its genetic repertoire. These observations highlight the need both to evaluate the ability of vaccines already deployed or in advanced development to neutralize the VOCs and to develop next generation vaccines with broader cross-reactivity. In this study, the cross-reactive neutralizing antibody responses elicited by AS03adjuvanted CoVLP (targeting the ancestral SARS-CoV-2 strain) were generally promising. Despite slight (1-2x) reductions in neutralizing activity for the B.1.351 (-1.1x) and B.1.617.2 (-2.0x) variants compared to the ancestral strain, two doses of CoVLP with AS03 still elicited high levels of serum cross-neutralizing antibodies against the VOCs tested. These observations are similar to those reported with other SARS-CoV-2 vaccines targeting the ancestral S protein [58,64] although the decrement in neutralization for VOCs was less pronounced for CoVLP, particularly for the B. [43,56,59]. Hence it is not a surprise that an important decrease in the neutralizing potential of antibodies against the B.1.1.529 variant strain was observed in the current study. Similar reductions in neutralizing antibody titers have been reported in both clinical trials [43,56,59] and studies in non-human primates immunized with ancestral SARS-CoV-2 vaccines [66,67]. In the current study, the decrease in neutralizing activity was less pronounced following the administration of the candidate B.1.351 vaccine compared to the vaccine based on the ancestral strain, possibly due to the closer phylogenic relationship between B.1.351 and the Omicron variants [68].
Despite these promising data, it is possible that one or more VOCs will eventually emerge that is/are no longer effectively neutralized by vaccine-induced immunity. It is in this context that Medicago and others have chosen to develop next-generation vaccine candidates targeting the B.1.351 strain since this strain is one of the most antigenically distant VOC to emerge to date. The B.1.351 variant has consistently proved to be difficult to neutralize in vitro [69,70] and has caused large decrements in vaccine efficacy in several randomized controlled trials [15][16][17]61]. In the current study, animals that received two doses of either AS03-adjuvanted CoVLP or CoVLP.B1351 mounted neutralizing antibody responses that were comparable for both homologous and heterologous strains while reports for other candidate B.1.351 vaccines in mice have shown either strong homologous (ie: B.1.351-specific) responses only [71] or the requirement for three doses to achieve high levels of NAbs [64]. The pattern of the NAb response was consistent across multiple VOCs in the current study with the CoVLP. B1351 candidate generally eliciting higher titers than the ancestral CoVLP and this difference reached significance for the P.1 (2.3x) and the B.1.1.529 (6.8x) strains. Although the level of crossneutralization in the animals that received CoVLP.1351 was lower for the B.1.1.7 (-1.6x) and B.1.617.2 (-4.0x) variants compared to the homologous response, such differences are expected given the genetic and antigen 'distance' between these VOCs [43]. Furthermore, while these relative decreases were observed, the absolute titers of cross-reactive antibodies induced by two doses of CoVLP.B1351 with AS03 against the VOCs tested was still substantial. These findings are consistent with observations of others [64,71,72] and suggest that vaccines targeting the original Wuhan-like strain may be eventually become suboptimal in the next stages of the pandemic, opening the door to less conventional vaccination approaches including heterologous prime-boost strategies.
Concern over the ability of any single S protein antigen to elicit a broad enough response to neutralize all of the known and possibly future VOCs prompted us to evaluate the possible benefits of a heterologous prime-boost strategy with the Wuhan-like CoVLP as the prime and CoVLP.B1351 as the boost; both adjuvanted with AS03. Heterologous vaccination strategies that use two distinct platforms and/or deliver two slightly different antigens have shown considerable promises for a wide range of viral pathogens that rapidly mutate such as HIV [73], hepatitis C virus [74] or influenza to both broaden the immune response and focus the response on conserved epitopes [75]. This approach was largely confirmed in the current study since the neutralizing antibody titers were consistently higher in the animals that had received the AS03adjuvanted CoVLP-CoVLP.B1351 regimen, reaching statistical significance over the AS03-adjuvanted CoVLP-CoVLP regimen for B.1.351 and P.1 strains and over the AS03-adjuvanted CoVLP. B1351-CoVLP.B1351 regimen for the ancestral strain. It is not currently known if these differences between high and very high neutralizing antibody responses will have any clinical significance. However, induction of very high initial titers is likely desirable since it is well-documented that antibody titers wane substantially with time after both natural disease and vaccination [76]. These observations are similar to the results recently released by others [72,77] [Pfizer, Novavax] but distinct from those reported by Moderna [71] in that no evidence of original antigenic sin was noted [78]. Since these animals only received two doses, it is currently unknown how humoral response against VOCs would be influenced by a third (booster) dose but others have reported very high and cross-protective neutralizing antibody responses both in animals [64,71] and human trials [65,79,80] after this additional dose.
Finally, it is worth noting that these observations focus entirely on vaccine-induced antibody responses and particularly on the induction of antibodies capable of neutralizing SARS-CoV-2 variants in vitro. Although many consider NAb levels to be a good candidate for a correlate of protection [81], this is a fairly limited evaluation of vaccine-induced immunity and it is very likely that non-neutralizing but functional antibodies and cellular responses also contribute to vaccine-induced protection [82]. Data from a large non-human primate study [83] as well as ongoing clinical trials [27,65,84] demonstrate that AS03-adjuvanted CoVLP stimulates multiple arms of the adaptive response to SARS-CoV-2. Results from Medicago's ongoing pivotal Phase 3 efficacy study [25] (NCT04636697), performed in different regions of the world where several VOCs have been circulating, demonstrated a good protection of the CoVLP vaccine (targeting the ancestral strain) against several VOCs such as B.1.617.2 and P.1. These results are in line with the non-clinical cross-neutralization data presented in this study. Based on these Phase 3 results, it is unclear what immediate benefit might be gained by switching to a heterologous primeboost strategy for primary vaccination. However, both the magnitude and the breadth of response need to be considered as SARS-CoV-2 continues to mutate under increasing immune pressure including the most recent example of the B.1.1.529 variant. The data presented herein suggest two doses of AS03-adjuvanted CoVLP or CoVLP.B1351 can induce a strong immune response against a broad range of VOCs. Moreover, recently published preclinical data also highlight the added value of a third dose [64,71]. These observations provide further support for the growing body of data suggesting that the use of heterologous antigens, whether B.1.351 of some new VOC yet to emerge, in either primary or third-dose booster strategies may have advantages over traditional homologous antigen vaccination approaches and further clinical trials will be needed to confirm the efficacy of such vaccination strategies.
Declaration of Competing Interest
The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
CD, SPR, GA, MAD, BJW and ST are either employees of Medicago Inc or receive salary support from Medicago Inc.
CG is an employee of the GSK group of companies and reports ownership of GSK shares.
Author Contributions
All authors contributed significantly to the submitted work. CD, SPR, GA, CG, BJW and ST contributed to design and execution of the study as well as analyses and presentation of the data. All authors contributed to critical review of the data and the writing of the manuscript. All Medicago authors had full access to the data. | 249067820 | 5,601 |
Oh no! Carla, dear sweet nice cook-with-love Carla took some very bad advice from her sous chef and came in third in the Top Chef finale. We weep. And now annoying smug Hosea walks away with the title and the 100K, and we can't quite decide if this is better or worse than annoying cocky Stefan winning. Ugh. Ugh, ugh. Carla! Hootie! Please! Just trust your gut and quit letting other people make you second-guess yourself!
A lesson for us all, I suppose, where "us all" of course means "me." I totally get Carla wanting to compete without being devious or nasty, wanting to play nice and get along with everyone. And I totally get her innate lack of self-confidence and tendency to let stronger personalities talk her out of her own good ideas in favor of their own shitty ones. Stand up, woman, and let your own merits be enough, because they are considerable.
She helpfully listed her favorite DC haunts in a chat with the Washington Post on Wednesday, so if I'm ever there you will find me lurking on 14th near Adams, hopefully whispering Hootie? every time a tall African-American chef-like woman walks by. | http://boltgirl.blogspot.com/2009/02/boo-hootie-hoo.html | 264 |
Journal issues: 6/2015
Pages: 393-413
Language: (RU, EN)
25 November, 2015
METHOD OF PREDICTING THE TIME INCIDENTS IN OIL MINES
FSBEI HPE "Ukhta State Technical University", Ukhta, the Russian Federation
Yagubov E.Z.
FSBEI HPE "Ukhta State Technical University", Ukhta, the Russian Federation
zav_eatp@ugtu.net
Zhuikov A.E.
FSBEI HPE "Ukhta State Technical University", Ukhta, the Russian Federation
Zakharov D.Yu.
FSBEI HPE "Ukhta State Technical University", Ukhta, the Russian Federation
In oil mines during accident situations in consequence of failure the quality of environment, where radio waves are propagated, changes. This fact in mines is possible to be considered as an influence of the multiplicative noise.
In the article there are results of researches about forecasting accident response time with an influence of a multiplicative noise. Influencing on amplitude of signal, a multiplicative noise is capable of disturbance of useful information receiving process, and in some cases loss of data about technological parameters is possible. If provided useful data reflects information about gas abundance in different divisions of a mine, the situation can be threatening.
The results of researches about the coordination of the law of distribution of this time with different laws on the criterion ω2, achieved from processing a large number of samples for sub threshold time, and it sets out the method for the numerical description of the generalized truncated normal law. In researches of probability characteristics of pre-threshold time are used as the experimental information obtained in the oil mine in Yarega Urban village.
It is shown that with comparatively low values of the distribution law of pre-threshold times, it is better correlating with normal or truncated normal law. In case of increasing in pre-threshold times it is distributed by the generalized truncated normal distribution.
For that reason, the results of calculations of numerical characteristics of the pre-threshold times for the proposed method for different conditions of the precision of the iterative process.
- Safety rules for oil exploration mining method: Approved. Resolution Gosgortechnadzor USSR of 11.04.86, №8. Gosgortechnadzor. M.: USSR, 1986. 250 p. [in Russian].
- Yagubov Z.H., Optimization methods for control and management of objects with distributed elements: // monograph ZH Yagubov. Ukhta UGTU, 2014. 132 p. [in Russian].
- Thermal mining development of oil fields: monograph // Y.P. Konoplev, V.F. Buslaev, Z.H. Yagubov, N.D. Tshadaya; a. Ed. N.D. Tshadaya. M .: Nedra, 2006.288 p. [in Russian].
- Tshadaya N.D. Comprehensive assessment of working conditions in the mines in the oil steam stimulation on the formation. Petersburg: St. Petersburg University, 1997.116 p. [in Russian].
- Valiev Т.А., Yagubov Z.H. Тhe question of optimization of controls at the mine oil // Math. universities. oil and gaz. 1990. №6. 44-48 p. [in Russian].
elimination landslides; elimination of emergency situation; multiplicative interference; the law of distribution of pre-threshold times; useful information; закон распределения предпороговых времен; ликвидация аварийного положения; ликвидация обвалов; мультипликативная помеха; полезная информация DOI 10.17122/ogbus-2015-6-393-413 References to this article (GOST) Yagubov Z.Kh., Yagubov E.Z., Zhuikov A.E., Zakharov D.Yu. METHOD OF PREDICTING THE TIME INCIDENTS IN OIL MINES // Electronic scientific journal "Oil and Gas Business". 2015. №6. P.393-413. URL: | cfd5b5f026598ad50816a594d26749b1 | 1,024 |
I was working on a personal project where I needed some way to to save URL's / Bookmarks of websites that I come across that I would like to reference at a later time.
After some time I had about 240 entries, which was all saved in MongoDB. I then decided to add a Search functionality within the app, and felt like Elasticsearch would be great.
There were a couple of great options out there to choose from, to ingest data from MongoDB to Elasticsearch, but as I am on a stage where I am strengthening my Python skills, I decided to write a Python Script that will connect to MongoDB and write each item into Elasticsearch.
Any feedback on this will be appreciated, what do you guys think? Any other strategies? | https://sysadmins.co.za/ingest-mongodb-items-into-elasticsearch/ | 155 |
Shraddha Kapoor is all set for the release of her next, Haseena Parkar which is a biopic of Dawood Ibrahim’s sisters life. After this film, she also has Chanda Mama Door Ke with Sushant Singh Rajput.
Looks like after films like Half Girlfriend, Ok Jaanu and Rock On 2, Shraddha’s kitty is finally full of substantial films! | 1eee1cbf18260538f64d95adeee95c82 | 90 |
The edition of May 2, 1945 of News Chronicle is considered one of the “15 most iconic newspaper headlines ever printed”.
An evergreen topic of unimaginative science fictions and alternative histories is that the Führer has survived the war and he is living his life in Argentina as an honest bourgeois, he is dragging on the miserable existence of a prisoner of the Soviet KGB, or else he is preparing his return on a secret military basis. However, the following photo document puts an end to all doubt. Adolf Hitler has in fact died and has been buried. In the Jewish cemetery of Bucharest, on October 26, 1892.
încetat din viaţă la 26 octombrie 1892, în etate de 60 de ani.
died on October 26, 1892, at the age of 60.
The shocking news were aired some weeks ago by the portal 20minutos.es, and at the moment it only spreads over the Spanish web. On the basis of its information, however, it was not difficult to search for the source which was a post of July 29 of the excellent Spanish blog in Bucharest Un vallekano en Rumania which had taken over the article of last October 12 published in Romanian at the portal frontpress.ro.
The Romanian portal, in its turn, referred to the book Filantropia, un cimitir plin de viaţă (Philanthropy, a cemetery full of life) by the Romanian Hebraist Marius Mircu (1909-2008) written on the Ashkenazi Filantropia, the largest Jewish cemetery in Bucharest. (The Sephardic Jews have their own cemetery, the Giurgiului, and until the Holocaust there existed also a third cemetery founded in the 17th century along Sevastopol Road. A short overview of them can be found at the site Metropotam dedicated to the history of Bucharest.) According to this reference, an employee of the Jewish cemetery by accident came across the tomb covered by weed in the 1940s, during the Fascist Antonescu regime, and fearing the possible consequences, he chiseled off the Romanian legend, leaving only the Hebrew one. It was only in 1987 that the Rabbi of Bucharest Moses Rozen ordered the legend to be restored.
The Romanian portal asserts that in Bucharest there was no family with the name Hittler, and that Adolf Hittler had immigrated from the formerly Austrian province of Bucovina. What is more, they assume that the word was not the name of the deceased but rather its profession, being a corrupt version of German “Hüttler”, hat-maker. This supposition, however, is untenable for a number of reasons. Why would have anybody written in German the profession of the deceased in a Romanian text, and with an archaic term instead of the modern “Hutmacher”, even that in a corrupt form, and, to top it up all – or to put the hat on it, as we say in Hungarian – as a family name, by pure mistake?
But the portal 20minutos.es goes further and claims that Marius Mircu discovered in the archives of Bucharest that Adolf Hittler had been a hat-maker, and he even had a workshop and a milliner’s shop in Bucharest. Whether Mircu really asserts this, it is impossible to ascertain for the time being. In fact, his book referred by the portals is such a rarity that apart from the articles on the tomb only two occurrences of it are found all over the net. It was published in 2001 in Bacău at the Egal publisher, and we have found only three libraries having a copy of it: the Library of Congress (with a misprinted place of publication), the British Library and the national library of Jerusalem. Két Sheng will try to obtain it through inter-library loan, and until he succeeds in having it, we are dead-locked as to the source of Hittler’s being a hat-maker.
Just in parenthesis, this reminds me that in the bookshops of Transylvania, at the sight of the multitude of local and private publications I always think: how many of these find their way to public libraries? Foreigners like me, if they do not regularly come here to buy, where can have an access to this multicolored and exciting local print culture? Probably nowhere, just like to Mircu’s monography.
Evreii americani comentând atitudinea dictatorului german faţă de cetătenii de rassă semită, au emis părerea că Hitler trebue să fie evreu, deoarece in decursul istoriei cei mai mari asupritori ai israeliţilor au fost renegati. Astfel o pildă printre cele mai ilustre o alcătueşte marele inchizitor Torrequemada, care era evreu botezat.
In consecinţă americanii au făcut apel la comunităţile evreeşti din toată lumea să cerceteze dac’a existat o familie austriacă, Hitler, înrudită cu cancelarul german.
Un evreu bătrân din Alexandria (Egipt) şi-a amintit c’ar fi cunoscut în România cu patru cinci decenii in urmă pe un oarecare Hitler. S’a adresat rabinului dr. Niemerower din Bucureşti, care de fapt a găsit în cimitirul Filantropia un mormânt datat 26 Octombrie 1892 şi a cărui piatră funerară o reproducem în ilustraţia noastră. (*) Mormântul e ai lui Adolf Hittler, supus austriac. El a venit în România din părţile Poloniei de azi şi s’a angajat cu portar la hotelul Boulevard.
E probabil că nu există nici o legătură intre decedatul Adolf Hittler şi cancelarul german. Oricum insă, se dovedeşte că numele Hitler poate fi şi un nome evreesc şi că ipoteza ca în vinele cancelarului german să existe sânge semit, nu este exclusă. Dealtminteri aceasta n’ar avea absolut nici o importanţă.
*) Mormântul poartă no. 9 şi se găseşte în rândul al 18-lea. Se găseşte în locul unde sunt îngropaţi săracii.
American Jews, commenting the attitude of the German dictator towards the Semitic race, have issued opinions that Hitler must be a Jew, because in the course of history the greatest oppressors of the Israelites have always been renegades. One of their most illustrious example is the great inquisitor Torrequemada who was a baptized Jew.
The Americans have therefore appealed to the Jewish communities around the world to investigate whether there exist any Austrian [Jewish] family of the name Hitler which is related to the German Chancellor.
An old Jew in Alexandria (Egypt) has recalled that some four or five decades earlier he had known a certain Hitler in Romania. He addressed to Dr. Niemerower, Rabbi of Bucharest who has in fact found a grave in the cemetery Philanthropy dated October 26, 1892 whose tombstone is reproduced in our illustration. (*) The grave was of the Austrian subject Adolf Hittler who had come from Poland to Romania and was employed as the porter of Hotel Boulevard.
It is probable that there is no connection between the deceased Adolf Hittler and the German Chancellor. However, since it appears that Hitler can be also a Jewish name, it is not excluded that there is some Semitic blood in the veins of the German Chancellor. Nevertheless, this has absolutely no importance.
*) The tomb bears number 9 and is found in the 18th parcel. It lays on the place where the poor are buried.
What might be the date of this article? The mention of Hitler as a “German Chancellor” and the no more than four or five decades that passed since the death of Hittler refer to the 1930s or 40s. The reference to Niemirower sets an even narrower limit to the possible date. The great reformer Chief Rabbi, a member of the Romanian Senate and the spiritual leader of all the Jews of pre-war Romania died on November 18, 1939. Therefore the article must have been published sometimes in the second half of the 30s, in the relatively anti-German climate under King Charles, before the internal crisis produced by the Soviet annexation of Bessarabia and Northern Bucovina as well as the restitution of Northern Transylvania to Hungary in 1940 opened the way to power to the pro-German Antonescu government. Under the new regime which through organized pogroms caused the death of almost 400 thousand Jews in Romania and in the Soviet territories invaded by the Romanian army (including Odessa) it would have been impossible to write about the Führer in this frivolous tone. And it is also very probable that, in contrast to the report of Mircu, the tomb stone was not accidentally discovered by an employee of the cemetery, but the Jews of Bucharest consciously tried to eliminate the provocative tomb inscription that some years earlier received too much publicity by the above and similar articles.
A closer look at the former image of the tomb proves how thorough work they did.
son of our teacher, Rabbi Shmuel.
Deceased on 20 Heshwan 5653.
May his soul be bound up in the bundle of life.
20 Heshwan 5653 corresponds to November 10, 1892. True, Romania only changed for the Gregorian calendar in 1919, and in the Julian calendar the Hebrew date can be in fact October 26. But according to the inscription the deceased was a Rabbi, and a Rabbi’s son. Did Marius Mircu see this, and if yes, how did he reconcile it with his assumed profession as a hat-maker? And with the porter’s position in Hotel Boulevard? The further we go in our research, the larger the confusion grows. “Adolf Hittler may have lived a beautiful life” we could say with the catchword of a popular Hungarian novel of the period, “but he had a death of vicissitudes”. | 1d4ef27b6d9318763cbe1b77f247dee9 | 2,399 |
Turno casalingo per l’Accademia Volley.
Domani pomeriggio è prevista al Rampone di Benevento la gara tra le giallorosse e la Todis CS Pastena, valevole per la tredicesima giornata del campionato di serie c, seconda del girone di ritorno.
Reduci da tre vittorie consecutive, le padrone di casa puntano ad allungare ulteriormente la striscia positiva, sarebbe l’undicesima vittoria su tredici gare di campionato, ma devono fare i conti con un avversario tutt’altro che facile. La squadra salernitana, oggi ottava, si rese protagonista all’andata di una gara superba e creò non poche difficoltà all’Accademia, nonostante il 3-0 finale per le giallorosse. Sicuramente il prosieguo della stagione ha poi confermato come poi quel risultato non fu frutto del caso e a distanza di settimana l’Accademia cercherà di bissare il successo dell’andata per consolidare la sua posizione e magari allungare sul Montoro, impegnato ad Aversa contro la capolista Volalto 2.0. E sarà proprio la squadra irpina l’avversario che attende le giallorosse nel turno successivo.
La partita di domani avrà inizio alle ore 18.00 presso la Palestra Rampone di Benevento.
Contro l’Ottavima è un’Accademia da 10!
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| https://www.accademianews.info/laccademia-riceve-il-pastena-al-rampone/ | 887 |
Catherine came over to the studio today for a photoshoot for her 16th birthday and brought friends Emily and Olivia with her. Her mum also came along with Catherine’s brother, Michael, so that we could shoot a couple of family portaits. Most of the shoot, however, was taken up with the girls and I think we got some great images using the mid-grey infinity curve with and without gels, plus the trusty B&Q fence panel :¬) More images to come tomorrow, but here are a few to be going on with.
To book your party shoot, for boys or girls, just call the studio on 01924 229800 to book the session. They are great fun and give you a lasting present.
| https://www.johngardnerphotography.com/catherine-emily-olivia-in-the-studio/ | 157 |
Q: How to write something in sure fire reports without using Assert? I am using Junit and Maven along with selenium. For reporting i am using surefire plugin. My requirement is to update the surefire reports with message on failure. It can be done using Assert but it will abort the test case. But i dont want to abort it but to just report it.
A: you can use the maven.test.failure.ignore property (system property on command line) like:
mvn -Dmaven.test.failure.ignore=true
or to ignore failures during build process you can use the configuration for the maven-surefire-plugin:
<configuration>
.
<testFailureIgnore>true</testFailureIgnore>
.
</configuration>
| 730543d466cd50e369b491fc575c8a062b587e6b | 181 |
BEIJING, Nov. 25 (Xinhua) -- Chinese educators have called for modifying students' methods of study to enhance their core qualities at a national seminar on in-class teaching.
More than 1,000 educators from across the country attended the seminar, discussing issues such as how education can meet the requirements of the reform of examination and evaluation, and how to support students' extracurricular practice.
Efforts to deepen educational reform should focus on the learners to further combine learning with thinking, while normalizing heuristic teaching and investigative study, according to Yang Yinfu, secretary general of the Chinese Society of Education (CSE).
He also suggested that teaching should be more customized in accordance with students' aptitudes, and that information technology and education should be further deeply integrated.
Held by the CSE and other organizations on Nov. 22 and 23, the seminar was the second of its kind. | http://english.cqnews.net/html/2019-11/27/content_50730290.htm | 189 |
An Intricate Web: Chemokine Receptors, HIV‐1 and Hematopoiesis
Cellular infection by the human immunodeficiency virus type 1 (HIV‐1) requires interaction of the viral envelope protein with CD4 and at least one additional cell surface molecule, termed a “cofactor” or “coreceptor.” Recent discoveries have determined that macrophage‐tropic strains of HIV‐1 which are largely responsible for sexual transmission require the β‐chemokine receptor CCR5 in addition to CD4, while the T cell tropic viruses that emerge later after infection use the α‐chemokine receptor CXCR4. Thus, both CD4 and the appropriate chemokine receptor must be expressed on the cell surface in order for HIV‐1 to enter the cell and establish an infection. The in vivo importance of CCR5 for HIV‐1 is demonstrated by the finding that individuals homozygous for a 32 bp deletion (Δ32) in the CCR5 gene that renders them effectively CCR5‐negative are highly resistant to virus infection. In this review, the structure‐function correlates of the chemokine receptors that serve as major coreceptors for HIV‐1 and simian immunodeficiency virus entry will be reviewed. Since certain chemokines have been implicated as stem cell inhibitory factors, the biological consequences of chemokine receptor expression as it relates to HIV‐1‐associated hematodyspoiesis will also be discussed. | 46400418 | 317 |
LI think your guys have access to a relic that essentially gives a character lieutenant re-rolls, so you might want to avoid the lieutenant unless there was a specific relic you wanted to take with you. A captain is a good option, especially if you have a decent amount of CP in your list so you can give him an aura of re rolling any hit roll if you need to.
Personally though, at that price I like the idea of a Phobos librarian, but I’m always massively high on that unit. As a fist, you get so many tools with him. You get psychic powers that buff his strength and toughness, heal himself or other multi wound models, and do orbital bombardments (not to mention getting in a good position to smite and deny psychic powers). You also get a relic to turn his pistol into a character killer, or to make him into a lieutenant, as well as all the defensive relics that are available. He also has a power that makes him harder to charge, so if you want to take an eliminator unit with a Sarge with the sniper bolt rifle (maybe for the special issue bolts), you might be able help protect them from charges with the right positioning. | 2c8ddf7fdb904356a56cc29efb9b3b29 | 249 |
The petitioners, refugees registered under the United Nations High Commission of Refugees, (15) argue that the deportation of the Rohingya refugees by the Indian government violates the principle of non-refoulement, which they assert is a principle of customary international law. (16) The Indian government, petitioners assert, is bound by the principle of non-refoulement since the Equality Clause, the Life and Liberty Clause, and Article 51 (c) of the Indian Constitution "obligate[] India to respect international law." (17) As a matter of law, the petitioners categorically assert, "The principle of non-refoulement--or not sending back refugees to a place where they face danger--is considered [a] part of customary international law and binding on all states whether they have signed the [1951 United Nations Convention on Status of Refugees] (18) or not." (19) Article 33(1) of the 1951 United Nations Convention on Status of Refugees (the "1951 Refugee Convention"), its "central normative and operational core," (20) enacts the principle of non-refoulement as a part of international treaty law. (21) As a matter of fact, the petitioners assert that they are covered by the definition of a refugee as provided in Article 1A(2) of the 1951 Refugee Convention. (22) Even though the fact that India has not ratified the 1951 Refugee Convention is not contested by the petitioners, (23) their stand is that the principle of non-refoulement, being a principle of customary international law, binds India anyway. (24) They further argue that India's non-ratification of the 1951 Refugee Convention is not determinative of the issue since India has ratified the Universal Declaration of Human Rights ("UDHR"), (25) the International Covenant on Civil and Political Rights ("ICCPR"), and the International Convention on the Elimination of All Forms of Racial Discrimination ("ICEFRD"). (26) The reliance on ICCPR is however slightly surprising because the ICCPR does not provide "a right to seek and enjoy asylum... [it only provides] the right to leave any country and the right to enter one's own country." (27) In addition, they argue that India being a signatory to several other international conventions against use of torture, inhuman or degrading treatment, and prohibition of forced disappearances, for example, makes the fact of non-ratification of the 1951 Refugee Convention irrelevant as these international treaties and conventions that India has ratified or signed "explicitly or otherwise, lay down the Principle of Non-Refoulement." (28) The petition also relies on two High Court opinions where the principle of non-refoulement has been read into the Life and Liberty Clause of the Indian Constitution. (29) On these grounds, they argue that the right of non-refoulement must be read into the Equality Clause and the Life and Liberty Clause of the Indian Constitution.
India is not a signatory to the [1951 Refugee Convention] and the [1967 Protocol] issued thereunder. The [1951 Refugee Convention and the 1967 Protocol] are therefore not binding upon India and no other Declaration/Resolution/Convention/international treaty or instrument of any kind is in force which prohibits India, as a sovereign nation, to exercise its right of deporting illegal immigrants in accordance with laws of India and thereby protecting the fundamental rights of its own citizens more particularly in the interest of national security. (35) The government's broad stand before the Court (both in the main and the supplemental response brief) is that the entire gamut of international law relied upon by the petitioners does not bind the Indian government with the principle of non-refoulement. (36) The logical conclusion thereof is that key fundamental rights provisions of the Indian Constitution (such as the Equality Clause or the Life and Liberty Clause) cannot be interpreted so as to include within their scope the principle of non-refoulement. With respect to the 1951 Refugee Convention, the government's categorical claim is that it "does not confer any legally enforceable rights either upon the petitioners or anyone else which can justify prayers for issuance of a writ of this Hon'ble Court under Article 32 of the Constitution of India." (37) To the extent that the key question that this article engages with is currently pending judicial consideration before the Supreme Court of India, this article also, but only consequentially, attempts to examine the position of the Indian government before the Supreme Court of India by asking the broader theoretical question stated at the beginning of this article. However, this... | https://international.vlex.com/vid/the-use-of-international-777566213 | 938 |
LINED SNAKE
Characteristics:
* Gray or brown in color
* Pale body stripes-one down the middle of back and one along each side
* Double row of black half-moons on the white or yellowish belly
* Keeled scales
* Nonvenomous
* Diet: earthworms and small insects
* Habitat: open prairie hillsides and rocky,
woodland areas
* Distribution: extreme southeastern South Dakota | f45cbffdfc4699be8a9d61fa8f9b93eb | 95 |
A trendy and modern stucco painting project completed by our friendly staff on a residential home in Edmonton. This stucco on this house was finished using Cloverdale Paint’s elastomeric coating. This two storey walkout was challenging at times due to the intricate nature of the building, but it was nothing our experienced staff could not handle. | http://www.thepaintingexperts.ca/portfolio-items/residential-interior-family-room/ | 73 |
Men With Hanging.
entrance into the cars.
tempting to carry out their threats.
delayed by the lack of laborers.
ed without a division.
provided in the recent veto act.
form of the House of Lords.
is recommended in favor of Mrs.
rington, who wilfully deserted her.
dren's Home, Montclair.
Jersey at the $ime of the desertion.
ously estimated at from $275 to $425.
paid cash down.
equivalent to $2,400,000 an ounce.
Banas ana Hretty r towers.
ductions in prices.
napkins to match; choice of new designs.
heavy quality pure flax.
ready for use; heavy quality pure linen; size qo-.
ready for use; at great reductions for this sale.
Size 18 in. 20 in. 22 in. 24 in. 27 in.
The first half of the July Furniture Sale is gone, and it has been notably successful.
and bargains offered.
Many of the good things have already been revealed, many more have been held in reserve.
In spite of the deep cuts made in prices Surety Coupons will be given with every purchase.
And any piece or suite may be bought on our unique easy payment Club Plan.
are on sale separately at the same proportionate reductions.
Sale price . .
S54.00; July Sale price..
able price of $60.
such liberally reduced prices.
Sale price only.
Kirkman’s Soap and Powder.
Babbitt’s Soap and Powder.
Octagon and Bee. And others.
Sweet Clover, Lion Brand, Star, Darling or Pearl.
tificates. Bring them in.
price of 29c.
med; value $10 to $12; special at.
tan and other shades.
Suits worth to $19.75 at $6.98.
Suits worth to $29 at $12.98.
Suits worth to $35.75 at $15.98.
Values to $45 at $19.98.
shades, long and three-quarter length models.
Coats worth to $10, at $3.98.
Coats worth to $30, at $12.98.
Leather and of Vici Kid.
posts 2Y* in.
| https://chroniclingamerica.loc.gov/lccn/sn91064011/1913-07-16/ed-1/seq-5/ | 519 |
style="text-align: justify;">The Nationals haven’t liked the offers they’ve gotten for 1B/OF Adam Dunn and think the team will not be trading the veteran power hitter, according to Bill Ladson of MLB.com.
The Nationals preference seems to be to sign an extension with Adam Dunn instead of trading him. The two sides haven’t been even close to one though so the Nationals have explored the possibility of trading him.
Even if it becomes clear that an extension becomes impossible, the Nats seem to be thinking that they might as well hold on to the type-A free agent and take the two first round draft picks if they fail to sign him.
| http://www.yankeetavern.com/ny-yankees/mlb-trade-rumors-latest-on-adam-dunn-and-the-new-york-yankees/ | 145 |
- Street View
- Bird's Eye
- Map View
20 Barney Hill Rd, Wayland, MA 01778
4 beds3 baths4,334 sqft
A Zestimate® home valuation is Zillow's estimated market value. It is not an appraisal. Use it as a starting point to determine a home's value. Learn more
Facts
- Lot: 0.98 acres
- Single Family
- Built in 1964
- Heating: Other
- Last sold: Jun 2012 for $742,000
- Price/sqft: $171
Features
- Deck
- Fireplace
- Parking: Garage - Attached
- Storage
- Tennis Court
Construction
- Exterior material: Wood
- Room count: 9
- # Stories: 1.0
- Unit count: 1
Other
- Floor size: 4,334 sqft
- Last remodel year: 1980
- Parcel #: M:44 P:034
- Zillow Home ID: 5712778 home values will decrease 1.1% next year, compared to a 0.8% decrease for Wayland as a whole. Among 01778 homes, this home is valued 46% more than the midpoint (median) home, but is valued 45% less per square foot.
Foreclosures will be a factor impacting home values in the next several years. In the 01778 market, the number of foreclosures waiting to be sold fell 5.7% in the last year. The number of unsold foreclosures is exactly the same as for Wayland, and 92.2% lower than the national average.
Learn more about forecast calculations or 01778 home values.… More Less
For Sale
- 80 Woodridge Rd4 beds, 3 baths
3,489 sqft, 47,480 sqft lot, built in 1955
- 15 Hobbs Rd4 beds, 3 baths
5,358 sqft, 61,855 sqft lot, built in 1964
- 22 Aqueduct Rd3 beds, 1.5 baths
2,240 sqft, 20,037 sqft lot, built in 1960
- 78 Loker St3 beds, 4 baths
3,924 sqft, 38,332 sqft lot, built in 1983
- 27 Brooks Rd5 beds, 3.5 baths
4,504 sqft, 29,185 sqft lot, built in 1989
- 281 Main St5 beds, 3.5 baths
3,750 sqft, 29,185 sqft lot, built in 2014
- 6 Keith Rd3 beds, 2 baths
1,640 sqft, 20,037 sqft lot, built in 1963
- 28 Pequot Rd3 beds, 2 baths
2,800 sqft, 50,529 sqft lot, built in 1953
- 26 Dudley Rd3 beds, 1.5 baths
1,260 sqft, 6,534 sqft lot, built in 1930
- 29 Shaw Dr4 beds, 5 baths
4,008 sqft, -- sqft lot, built in 1954
- 62 E Plain St2 beds, 1 baths
1,106 sqft, 16,117 sqft lot, built in 1890
- 215 Old Connecticut Path3 beds, 2 baths
1,697 sqft, 20,037 sqft lot, built in 1945
- 8 Old Farm Rd4 beds, 2 baths
2,716 sqft, 22,090 sqft lot, built in 1953
- 307 Willow Brook Dr # 3072 beds, 3 baths
2,232 sqft, -- sqft lot, built in 1997
- 2 Old Farm Rd3 beds, 3 baths
2,110 sqft, 20,037 sqft lot, built in 1953
Rentals
- 28 Pequot Rd # 283 beds, 2 baths
1,684 sqft, -- sqft lot, built in 1953
- 9 Dunster Ave # 12 beds, 1 baths
1,328 sqft, -- sqft lot, built in 1880
- 15 Harrison St # 22 beds, 1 baths
1,000 sqft, -- sqft lot, built in --
- 10 Langdon Rd4 beds, 2.5 baths
2,500 sqft, 20,037 sqft lot, built in 1973
- 250 Lake Shore Dr # 01 beds, 1 baths
491 sqft, -- sqft lot, built in 1920
- 250 Lake Shore Dr1 beds, 1 baths
491 sqft, 6,663 sqft lot, built in 1920
- 6 Dairy Farm Ln5 beds, 9 baths
7,399 sqft, 109,771 sqft lot, built in 1992
- 9 Bayberry Rd # SF4 beds, 2 baths
2,200 sqft, -- sqft lot, built in 1989
- 69 Rathbun Rd # 15 beds, 3 baths
2,770 sqft, -- sqft lot, built in --
- 29 Beverly Rd2 beds, 1 baths
1,019 sqft, 10,019 sqft lot, built in 1950
- 140 Overbrook Dr # 02 beds, 1 baths
784 sqft, -- sqft lot, built in --
- 29 Lasalle Ave3 beds, 2 baths
1,260 sqft, 20,473 sqft lot, built in 1954
- 620 South Ave4 beds, 3.5 baths
4,500 sqft, 113,579 sqft lot, built in 1980
- 17 Derby St3 beds, 4.5 baths
2,100 sqft, 9,148 sqft lot, built in 1998
- 757 Wellesley St # 03 beds, 2 baths
2,850 sqft, -- sqft lot, built in! | 2f12ab03ad7914d3cdeb3a4b83343b94 | 1,211 |
Home / Technology / These are the differences between vulnerability and threat.
Today, with the news related to cyber-security in all the covers, we're more than accustomed to listen to or read the concepts threat or vulnerabilityAlthough there are many people that use them as synonyms, in reality they are two different things, related but different.
Explained in a fast way, in short, the vulnerabilities are the conditions and characteristics of the systems that make them susceptible to the threats.Therefore, it is necessary that there be a vulnerability for which there is a threat. However, we are going to be defined in detail for an understanding of both concepts.
To understand the difference between vulnerability and threat, in the first place we have a clear definition of each one of them. Vulnerability computer is this a fault or weakness in the information system that puts in danger the security, and therefore compromise the integrity, availability or confidentiality of the data. For this reason, it is of vital importance to find these holes as soon as possible, so as to be able to find solutions quickly.
A threat refers to the action that exploits a vulnerability to compromise the security of an information systemIt can come from malicious attacks, events, physical or neglect, and institutional decisions, and can be internal or external to the talk about organizations.
Malware: it gives attackers many opportunities to exploit the computer, whether it's spying on personal and private data or carrying out any malicious action with the goal of hurting the victim.
Social engineering : it is the employment of techniques of persuasion to trick users with malicious intent, such as theft of information, and then carry out other attacks or to sell data on the black market.
APT or advanced persistent threats: they are coordinated attacks that apply social engineering, targeted against an organization with the goal of stealing or filter information without being detected.
Botnetsa network of infected computers controlled by the attackers that are used in other most sophisticated attacks, such as denial of service attacks or ddos.
Cloud services: cloud services: it is also a common source of threats for computers.
Another factor to take into account: the risk.
Risk must also be taken into account in this operation. It is the possibility of a security issue, and it materializes in the event of loss or damage. to measure it, it is necessary to determine the probability that a threat exploits a vulnerability and causes harm or impact. In function of the values obtained is set to a level of risk or the other.
It is very important to try to quantify the risk and put the appropriate measures in order to reduce, as in this way they decrease the chances of occurrence of a security problem. | https://soporteti.org/en/2020/09/21/estas-son-las-diferencias-entre-vulnerabilidad-y-amenaza/ | 545 |
National Australia Bank Europe S.A.
The specialist banking partner of choice in infrastructure, renewables, and subscription finance.
National Australia Bank Limited (NAB) has been operating in Europe for nearly 160 years. Our London Branch was opened in 1864 to provide clients with local expertise and insight into European markets.
In 2022, NAB established its new subsidiary in Paris, France as a credit institution to meet the growing needs of our clients.
NAB’s clients are increasingly active in Europe. They’re seeking banking partners that understand their needs, have a strong credit rating and show long-term commitment.
As we all transition to a more sustainable future, NAB Europe’s purpose is to serve our clients well and help the communities in which we operate prosper. Our aim is for NAB Europe to be a banking partner of choice in our specialist areas.
Nicola was appointed as Chief Executive Officer (Directeur Général) of NAB Europe in February 2022. In her role as CEO, Nicola has responsibility for all business activities across the European region covering Markets, Lending, Debt Capital Markets and Corporate Finance.
Prior to relocating to Paris, Nicola was Head of Northern Hemisphere Solution Sales at NAB in London for 16 years. Nicola and her team were responsible for providing interest rate, inflation, foreign exchange and commodity products to hedge risk for Corporates and Financial Institutional clients.
In a financial career spanning almost thirty years, Nicola has extensive experience across banking and financial services and a proven track record in growing sustainable businesses offshore. Nicola is passionate about building trusting relationships with clients, has effectively managed and led highly engaged global teams, is prudent in managing risk and managing capital, and has a deep product knowledge across multiple areas in banking.
Nicola is a member of the FICC Markets Standard Board Ethics and Conduct Sub Committee.
Nicola is a strong advocate and role model for flexible working having managed her career at NAB on a four day working week over the last 14 years. Nicola is married to Mark and they have three children.
© National Australia Bank Europe S.A. (884 564 642 RCS Paris) is a société anonyme incorporated in France and is a subsidiary of National Australia Bank Limited (ABN 12 004 044 937), with its registered office at 24 rue des Capucines, 75002 Paris, France, and a share capital of EUR135,000,000. National Australia Bank Europe S.A. is authorised and regulated by the Autorité de Contrôle Prudentiel et de Résolution and the Autorité des Marchés Financiers. National Australia Bank Europe S.A. is covered by the Fonds de Garantie des Dépôts et de Résolution (FGDR). It is not an Australian authorised deposit taking institution and is not guaranteed by National Australia Bank Limited.
You are now leaving the National Australia Bank Europe S.A. website and will be directed to National Australia Bank Limited. Click continue to visit National Australia Bank Limited, or close this pop up to stay on the National Australia Bank Europe S.A. website. | https://www.nabeurope.com/ | 657 |
School's Address:
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Arroyo Grande, California 93420
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New Delhi Metallo-beta lactamase-1 containing enterobacteriaceae: origin, diagnosis, treatment and public health concern.
One of the biggest problems associated with the antibiotic therapy is resistance. Recently published studies have revealed that enterobacteriaceae, like E. coli and Klebsiella, isolated from several Indian centers are resistant to many antibiotics including some highly potent antibiotics like carbapenems. It has been proposed that this resistance is because of a carbapenemase enzyme called NDM- 1 (New Delhi Metallo-betalactamase-1). This carbapenemase is class B carbapenemase also called metallolactamases as they require zinc at their active site. This enzyme is coded by a gene called bla - NDM -1 or gene NDM -1. NDM -1 containing enterobacteriaceae can be screened in laboratory by few techniques. Metallolactamase production can be detected by disk approximation test or Modified Hodge test and NDM -1 gene can be detected by polymerase chain reaction by the use of specific primer targeting the gene. Infections caused by such bacteria are associated with high morbidity and mortality. Two classes of antibiotics i.e., polymyxins (colistin) and glycylcyclines (tigecyclines), have shown in vitro activity against NDM -1 harboring enterobacteriaceae. The safety profile of both of these antibiotics is questionable. There is a need for active screening of microorganisms for NDM -1 and research should be directed towards the development of safe antibiotics for the treatment of these kinds of infections.
Introduction
Microorganisms existed on this earth millions of years before the evolution of man. Revolution in the medical sciences during the 19th century, along with the advent of antibiotics aroused a hope to do away with the microorganisms of concern to man, but today microbial resistance to antibiotics continues to be a serious threat to mankind. A number of articles published in indexed journals predict that, in near future, we may encounter a group of entirely new bacteria which may not be amenable to any of the presently available antibiotics This could have a tremendous impact on the advanced medical procedures like organ transplantation, bone marrow transplantation and cancer chemotherapy [1]. Kumarasamy et al, in a study published in Lancet Infectious Disease journal, reported that enterobacteriaceae isolated from two centers in India were highly resistant to all antibiotics except colistin and tigecycline.
Majority of these organisms carried a novel gene on their plasmid which was named as New Delhi Metallo-betalactamase (NDM -1, bla NDM-1). Kumarasamy et al also reported that isolates from Haryana had a similar genetic finger print. This is indirect evidence for their common origin and, hence a potential epidemic threat [2]. Walsh T et al, in a study published in Lancet Infectious Disease journal, found that seepage and tap water collected from New Delhi contained microorganisms resistant to all known antibiotics except colistin and tigecycline which contain bla NDM -1 gene [3].
These studies were received with criticism. There were issues related to the naming of the gene after an Indian city, invalid methodology, and illogical conclusion [4][5][6][7][8]. In the midst of criticism and controversy, one cannot deny the fact regarding existence of a "superbug", resistant to all known antibiotics and the need to prevent the rapid spread of such organisms. Though the information existed previously, the awareness of NDM -1 containing microorganisms only came about after the publication of Kumarasamy et al's study [2]. A PubMed and Google search was done using MeSH term "NDM -1" or "New Delhi Metallolactamase-1". The authors found 12 articles ( Table 1) reporting NDM -1 gene containing bacteria (reviews, letters, articles related to laboratory investigations were excluded) [9][10][11][12][13][14][15][16][17][18].
A recently published surveillance study discovered, that enterobacteriaceae containing NDM -1 were present in New Delhi from as early as 2006 [19]. But, the first significant study addressing the problem of NDM -1 gene containing multidrug resistant microorganism was a case report by Yong et al [9]. In this case report, carbapenem resistant Klebsiella pneumoniae, isolated from the urine of a 59 year old Swedish resident of Indian origin, was found to be harboring NDM -1 gene. The patient was suffering from type 2 diabetes with a history of multiple strokes. During his stay in India, he was operated for gluteal abscess at Ludhiana (Punjab), and for decubital ulcer at New Delhi.
The problem was again highlighted by Deshpande et al in a study published in Journal of Association of Physicians of India [10]. In this study, out of 24 carbapenem resistant Enterobacteriaceae recovered from a tertiary hospital, 22 were found to be harboring NDM -1 gene. Out of these 22 NDM -1 positive Enterobacteriaceae, 10 were Klebsiella spp, 9 Escherichia coli, 2 Enterobacter spp and one isolate of Monganella morganii. NDM -1 positive Enterobacteriaceae were also reported from other countries among patients, who had travelled to India, Pakistan and Bangladesh [11][12][13][14][15][16][17][18]. This caused controversy after the publication of Kumarasamy et al [2] and Walsh et al [3], reporting NDM -1 harboring Enterobacteriaceae in Indian patients and water in New Delhi respectively.
NDM -1(New Delhi Metallo-betalactamase -1) is a carbapenemase beta lactamase enzyme. This enzyme is coded by blaNDM -1or NDM -1 gene. This gene encodes, 269 amino acids containing protein, with molecular mass of approx 27.5 kDa [1]. Carbapenemases are beta lactamase which can hydrolyze the beta lactams, particularly carbapenem. They are resistant to clavulanic acid, salbactum and many other commercially available beta lactamase inhibitors.
Broadly carbapenemases are categorized into four groups; Class A: Penicillinases, Class B: Metallolactamases, Class C: Cephalosporinase or ampC and Class D: Oxacillinases [20]. NDM -1 belongs to class B-Carbapenemase. The characteristic property of class B carbapenemase is that, they require zinc at their active site; hence they are called as metallolactamases. The activity of these enzymes can be inhibited by Zinc chelating agents like EDTA [21]. Metallolactamases also hydrolyze cephalosporins and penicillins. Aztreonam resist hydrolysis by metallolactamases [21]. The bla NDM -1 gene is accompanied by other genes responsible for resistance to antibiotics, like erythromycin, ciprofloxacillin, rifampicin and chloramphenicol. It is also accompanied by a broad spectrum beta lactamase (CMY -4), also a genetic element, which encodes for efflux pump and its promoters. All these accompanying genes make bla NDM -1 more dangerous in causing multidrug resistance [22].
In the Kumarasamy et al study, it was noted that blaNDM -1 also coexisted with amino glycoside resistant genes like blaOXA-23 and armA [11]. A similar study by Poirel et al, observed that the NDM -1 gene in a strain of Citrobacter freundii was accompanied by 9 different types of beta lactamase [23]. The blaNDM -1 gene is located on plasmid, which can be easily transferred to other bacteria by conjugation, and it is found to be located on plasmid of different sizes, which predicts its mobility and pathogenesis [24]. NDM -1 positive organism can get colonized in the gut in the absence of any feature of disease. As most of these organisms are normal commensals of the gut, the screening of these organisms is a difficult task [24].
Identification of bacteria can be done by automated systems like Phoenix or by API 20 E Strips [2]. Elevated Minimum Inhibitory Concentration (MIC) to carbapenem is the foremost event that can indicate the carbapenemase (metallo -beta lactamase and other) production [21]. Elevated MIC predicts carbapenemase production in enterobacteriaceae but it cannot predict total clinical resistance [21]. MIC can be measured by microbroth dilution, agar dilution or by disk diffusion. According to recent guideline by Clinical Laboratory Standards Institute (CLSI), if an organism is resistant to carbapenem in accordance with CLSI cut off points, then there is no further need to go for phenotype testing by other methods like modified hodge. This holds well not only for clinical reporting, but for epidemiological and research purposes. Carbapenem resistant bacteria detection by MIC method, should be further explored for carbapenemase production by phenotypical methods [25]. It is very important to understand that the variability in susceptibility of cabapenem seems to depend on the type of automated system used [26].
Production of metallo -beta-lactamase can be identified by disk approximation test (or double disk synergy test) using EDTA as metal chelater. In disk approximation test, clear zone (zone of inhibition) around the beta lactum disk, is increased in the presence of zinc chelator like EDTA. It is observed that imipenem-EDTA combination was most sensitive for metallo beta lactamse production [27]. Metallo beta lactamse can also be confirmed by Etest strip. E test strip of imipenem and imipenem-EDTA combination is used to detect metallo-beta-lactamase production. Three fold or greater decrease in MIC of imipenem in the presence of EDTA indicates the production of metallo-beta-lactamase, but there are possibilities of false positivity and false negativity. False negative results, when MIC of imipenem is less than 4 microgram/ml [27]. False positivity results, in the presence of OXA genes or direct action of EDTA on microorganism by changing former's permeability [28]. Modified Hodge test can also be used for the same purpose. This is a phenotypic test for confirming the presence of carbapenemase (metallo -beta lactamase) production. Cloverleaf indentation at the intersection of the test organism and standard strain, within the zone of inhibition of carbapenem disk shows positive result for carbapenemase production [29]. The advantage of this method is that even the weak carbapenemase activity enzyme can be detected [21]. Other methods like isoelectric focusing and imipenem hydrolysis can also be used for the same purpose [21]. Presence of bla NDM -1 can be detected by polymerase chain reaction by the use of specific primer targeting the gene [2,9,10,21].
Treatment of infection caused by NDM-1 harboring Enterobacteriaceae
Infections caused by such bacteria are associated with high morbidity and mortality. Even though specific data on NDM -1 positive organisms is not available, there is indirect evidence to suggest that carbapenemase producing Enterobacteriaceae infection is associated with high crude and attributable mortality. In a study by Bores A et al, it was observed that crude mortality and attributable mortality in the patients of carbapenemase producing Kliebsella pneumoniae bacteremia was 71.9% and 50% respectively [30]. In a similar study by Patel G et al, it was noted that mortality among the cases with carbapenemase resistant Klebsiella pneumoniae was significantly more as compared to control (40% Vs 20%). Timely administration of in vitro sensitive antibiotics was not associated with survival [31]. Two classes of antibiotics i.e., polymyxins (colistin) and glycylcyclines (tigecyclines), have shown in vitro activity against NDM -1 harboring Enterobacteriaceae. On the basis of in vitro sensitivity analysis of 37 British isolates, 50% and 90% MIC for colistin was 0.5 mg/ L and 8 mg/L respectively ,and for tigecycline, it was 1 mg/L and 4 mg/L [32]. In the Kumarasamy study, it was observed that 89% of UK isolates were susceptible to colistin and 64% to tigecycline. Out of all Indian isolates, more than 50% were sensitive to tigecycline and all were sensitive to colistin [2], but the chances of resistance are also high. In the Kumarasamy et al study one isolate (from Chennai) was highly resistant to all known antibiotics. A similar finding was also observed in studies done in Greece and New York [33,34,35]. Resistance to colistin and tigecycline should be a reason for worry, as it indicates a return to the pre antibiotic era [32]. Along with resistance, one more limitation of drug therapy in such infections is toxicity. Colistin group was practically abandoned 30 years ago due to its nephrotoxicity. In a study by Souli et al, it was observed that, attributable mortality by colistin containing regimen in patient infected by carbapenemase producing Klebsiella pneumoniae was around 19% [33].
Tigecycline is a relatively new antibiotic. In a small number of studies, it was observed that Tigecycline has favorable outcomes in 70% of the patients infected with carbapenem and multidrug resistant organisms. But, a recent US Food and Drug administration update warned about the increase in mortality among patients taking tigecycline as compared to other antibiotics [36]. A combination of tigecycline and colistin has been explored in some studies done for carbapenemase producing Enterobacteriaceae.
Cobo J et al , observed that colistin and tigecycline combination is synergistic [37]. Pournaras et al, on the basis of time kill assay, studied the effect of tigecycline alone, and its combination with meropenam and colistin, on carbapenemase producing Klebsiella pneumoniae strain. It was observed that as a single agent, none of the three antibiotics (tigecycline, meropenam and colistin) showed bactericidal concentration. Tigecycline and colistin, when given together produced bactericidal effect [38]. Some studies also reported the successful treatment of pan resistant Enterobacteriaceae with combination therapy of colistin and tigecycline [39]. Combinations using aztreonam or any other monobactum which are resistant to hydrolysis by metallolactamases are recommended by some studies. Here it is important to understand that NDM -1 containing bacterial strain may also have other carbapenemase like ampC or ESBLs which may hydrolyze the aztreonam. So inhibitors of these enzyme (like NXL104) should be the part of such combination therapy [40]. Fosfomycine is also suggested for use in carbapenemase producing pan resistant Enterobacteriaceae [41].
Public health concerns and way forward
India has quite a lot of skilled physicians and nurse practitioners. Over the last two decades, the economic boom in India has led to the expansion of infrastructure with medical facilities, at par with the medical care that the west has to offer. While some small countries may be viable as alternatives for minor surgical procedures, India is the only mainstream option that offers a comprehensive solution for any and all medical needs, and it does this with the highest levels of service, facilities, and professional skills. A complex transplant or bypass procedure can be achieved with a fraction of the cost as compared to U.S.A [42].
Several published articles particularly case reports show link, between NDM -1 containing pan resistant Enterobacteriaceae and India. It has been argued, that these "superbugs" originated in Indian subcontinent [2,3,9]. Various factors like over the counter use of antibiotics, irrational use of antibiotics, easy accessibility of higher antibiotics, poor sanitation, high prevalence of diarrhea and overcrowding are considered responsible for development and spread of these organisms [9]. A Lancet Infectious Disease study, warned patients against going to India for medical treatment as they may get infected with these organisms, which ultimately cost more than "the short term saving" [2]. This conclusion was questioned by press, politicians, scientists as well as the first author of the same study [4]. Recent study which shows the presence of NDM -1 harboring organism in New Delhi water, but absence of such organism in Cardiff water, indicates that the problem is more severe in countries like India. Instead of denial, there is a need to understand the severity of the situation, the burden it can pose in future, and to develop the necessary strategies to halt the development and spread of NDM -1. Steps are already being taken in western countries [24,43,44] and similar or more aggressive steps are needed in India. An active surveillance system encompassing various microorganisms should be put in place. There is a need for an appropriate system by which recent trend of bacterial susceptibility to various antibiotics can be notified at various levels. There is also a need of National Reference Laboratory and Research Institute for systematic study and vigilance of antibiotic resistance. Monitoring of prescription is required to be done regularly in hospitals and irrational or inappropriate use of antibiotics be discouraged. Unethical promotional policies of pharmaceutical companies should be taken seriously as it is duly observed, that many of the claims made in promotional material distributed by pharmaceutical companies, are not supported by valid evidence [45]. Clinicians instead of relying on pharmaceutical companies for information related to any drug including antibiotics, try to find out for themselves through journals or by participating in CMEs, conferences. Knowledge and effective management of locally endemic infectious diseases needs to be given more emphasis in both undergraduate and postgraduate curriculum [1]. Clear cut antibiotic policies in every hospital should be implemented and the use of reserved antibiotics left for cases of utmost need only.
The same has been advocated by the WHO in its 2011 World Health Day theme "Combat Antimicrobial Resistance: No Action Today, No Cure Tomorrow". Stringent laws to curb selling of over the counter (OTC) antibiotics have to be discussed and implemented at the national level. Facilities for detection of NDM -1 are to be made accessible to all hospitals and some molecular or diagnostic probes should be developed for rapid detection of this gene in bacteria [46]. This is an opportune time for health policy specialists, scientists, academicians and government official to collectively analyse the present situation and take some concrete steps for prevention as well as spread of this resistance.
Conclusion
Because of the irrational use of antibiotics more and more microorganisms are developing resistance to available antibiotics. Enterobactareaceae class of microorganisms is clinically very important and emergence of resistance to almost all antibiotics in this class should be matter of concern to clinicians and health authorities. Clinicians should be trained about the rational use of antibiotics and legislative changes should be done to prevent widespread and irrational use of antibiotics. | 7943511 | 4,190 |
"The involvement of the Secretary of HUD and MyPillow.com in pushing a dubious product at the highest levels should give Americans no comfort at night about their health and safety during a raging pandemic." — an unnamed administration official, discussing President Trump's fascination with Oleandrin, an unproven new COVID treatment being flogged by two of his advisers.
The all-virtual Democratic Convention starts tonight, and will be on from 9-11 pm ET. Michelle Obama and Bernie Sanders have prime speaking slots. Republican John Kasich will also get a platform to excoriate Trump.
Postal Service crisis deepens, with seven states preparing to sue the Trump administration. They want to stop USPS cuts that they say will undermine mail-in balloting, which President Trump says is his intention. Speaker Pelosi summoned the House back into session to investigate the USPS controversy.
White supremacist groups clashed with BLM protesters in Portland and elsewhere. Extreme right groups including the Proud Boys and American Wolf showed up with sticks, paintball guns, and pepper spray, and fought with BLM demonstrators. At least two shots were fired in Portland.
Operation Warp Speed won't reach most Americans by January 2021. Even in the best case, most Americans wouldn't get a vaccine until March.
President Trump is now being explicit about why he wants to deny funding to the US Postal Service. He wants to reduce the impact of mail-in votes by hurting the Postal Service's ability to deliver them in time for the votes to be counted.
As far as election-rigging schemes go, this one is simple and brilliant.
It does not involve hacking or fraud. It doesn't involve dumping boxes of ballots in rivers. It doesn't involve payoffs to corrupt election officials. It doesn't involve illegal gerrymandering or physical vote suppression. It doesn't involve rewriting election laws. It doesn't even involve the election system at all!
Instead, it takes advantage of existing election laws, Trump's successful undermining of confidence in mail-in voting among GOP voters, and Trump's control of an otherwise unrelated arm of the federal government — the Postal Service.
First, as Insider's Grace Panetta reports, Trump's bogus but frequent claims that mail-in voting involves massive fraud has made Republican voters less comfortable with vote-by-mail than Democratic voters. This and other factors may lead to more Democrats voting by mail than Republicans.
Meanwhile, as Panetta also reports, laws in Michigan, Florida, Wisconsin and other key battleground states require that mail-in ballots be received by Election Day to count. If the ballots arrive late, the votes don't count.
Meanwhile, a loyal Trump supporter now runs an organization that can determine when ballots arrive — the US Postal Service — and he is already reducing the speed with which the USPS delivers mail.
Cheap, mediocre COVID tests could be the pandemic's magic bullet.
COVID testing, like almost every aspect of the American response to the pandemic, has been a disaster. Tests are expensive and exceedingly slow. You don't get your results back for days — or even weeks — meaning you're very likely to spend your most contagious hours spreading the virus as you wait for a result. Plus they're hard to get, so only a tiny fraction of the people who should be tested actually are tested.
But finally, finally, there's a great, attainable, new idea for revolutionizing testing — a new testing protocol could stop the pandemic cold, and bring us the benefits of a vaccine without a vaccine. The basic notion is that we should mass produce very cheap, very fast, and somewhat inaccurate at-home COVID tests, and millions of us should take them daily. The architect of this plan is Harvard epidemiologist Michael Mina, who's outlined his case in the New York Times, the Atlantic, and in a podcast interview with me, among other places.
The technology exists. A few small companies have developed COVID saliva tests that you can do in 15 minutes at home. (The tests — essentially a strip of treated paper — works a bit like home pregnancy tests.) In Mina's scenario, we would mass produce these tests, which would cost $1 to $5 each, and tens of millions of us would take them every day — any kid before going to school, any worker before heading to the office. If you tested positive, you'd get the result immediately and you stay home. This would break chain after chain of transmission, and crush the pandemic as effectively as a vaccine.
So why aren't we doing this? The FDA won't approve the cheapo tests because they're not as accurate as the gold-standard PCR tests. They use a different, less precise method, and only catch people with a higher level of circulating virus. But Mina points out that this is actually the strength of these cheap tests — which are more "contagiousness" tests than "diagnostic" tests.
Mina told me he's getting calls from top officials around the world — "crown princes" — about trying this out, and he knows the idea has made its way to Jared Kushner's office. The US is practically the only country that has enough community spread where this kind of mass home testing makes sense. Other countries accomplish the same crackdown with vigorous contact tracing.
The latest wicked — utterly wicked — twist in the Trump administration's policy of expelling migrant children.
The Trump administration is diabolical sometimes. Today brings the usual cascade of horrors aimed at immigrants. The administration is raising the cost of naturalization by 80%, and also reducing fee waivers, punishing immigrants who have earned the right to become Americans.
And as the New York Times discovered, Trump's immigration officials have hired a private company to detain hundreds of migrants secretly in hotels, outside the formal detention system, so they're not subject to the rules protecting them from maltreatment. Most or perhaps all of these detainees are children, some of them babies, and they are held in hotels before being rapidly expelled back to their home countries or handed over to Mexican child welfare officials.
But that's not the truly diabolical part. The diabolical part is that the administration is deporting these hotel children without assigning them identification numbers. As the Times reports, "Searching for the children has been made nearly impossible because they are not being assigned identification numbers that would normally allow families to track their locations in the highly regulated federal detention system."
You can argue about whether secret hotel detentions and summary expulsions are fit and proper American policies.
Imagine if these were your children. You cannot argue — as a human being, as an American — that it is right to multiply the terror of children and the fears of their parents by intentionally hiding their identity, and making it impossible for their parents to find them.
The Bizarro Democratic National Convention starts this week in "Milwaukee."
There will be a video control room and a podium set up in Cream City, but none of the delegates will be there, nor will almost all the political reporters. Even Joe Biden will not be leaving the cozy confines of Delaware. The DNC conceded months ago that the event would be nearly all-virtual, so they've had some time to plan.
Republicans (or more specifically, Trump) still held out hope for a massive in-person convention as recently as last month. As a result, the RNC (which runs this Friday through next Monday) will likely be more a fly-by-the-seat-of-your-pants experiment in nightly television.
I'm a political journalist, so I pay more attention to these absurd quadrennial displays of hyper-partisan navel-gazing more than the average American (and that's to their credit). But I've got to admit, I'm irrationally bummed out that the Democratic and Republican National Conventions aren't happening this year.
I would have liked to have seen whether dissident Bernie Sanders supporters would truly play ball with the victorious establishment this time around — rather than storm the press tent in anger like they did in Philadelphia four years ago.
I'm wondering if Trump supporters would have put together a more despicable RNC-adjacent event than the one headlined by Milo Yiannopoulous that tried to sell Islamophobia, white nationalism, and the alt-right as part of a gay rights agenda.
Protests are a big part of every convention, but with such political and social unrest as we've seen this year, I'd have been curious to see exactly who showed up — and how the city, the police, and the protests would make it all work. Instead, the coronavirus pandemic has forced the conventions to go "virtual" — a word that's now synonymous with online communication, but which Oxford also defines as an adjective meaning "almost or nearly as described."
Travis Kalanick allegedly threw a party during the California COVID spike. The Uber founder and former CEO's LA party was allegedly smaller than the ones he threw before the pandemic, but it was still a party.
Pepperoni prices have spiked 50%. Pizza demand is way up, but the pandemic has constrained pork production.
Lionel Messi is demanding to leave Barcelona, the only club he's ever played for. Barcelona is a mess, and was humiliated 8-2 by German rival Bayern Munich over the weekend, so the greatest soccer player ever wants to finish his career elsewhere.
Philadelphia's annual Naked Bike Ride has been canceled because of the pandemic. It usually draws thousands of naked riders, and honestly sounds very painful.
Ex-"Ellen" staffer compares show environment to "The Devil Wears Prada." A grueling barrage of humiliation, cruelty, disrespect.
Nike's Vaporfly shoes are so fast that runners sponsored by other companies are wearing them. And blacking out the Nike logos. The Vaporflys have been involved in every major running triumph since 2016.
Obama has privately wondered if Biden could "f — k things up." According to Politico, the former president is worried his veep doesn't have a warm enough connection with voters, and could blow the election.
| https://mobile.businessinsider.com/trumps-plan-to-steal-presidential-election-simple-brilliant-2020-8 | 2,079 |
The first day of the Conrad Murray trial was yesterday, and two witnesses were called to the stand: Kenny Ortega, and Paul Gongaware. Both witnesses discussed Michael Jackson, and their professional relationship with the superstar. Gongaware, the CEO of AEG took to the witness stand yesterday, and discussed the This Is It tour date that the King of Pop was working to launch prior to his passing.
As TMZ reports, there are some key things that Gongaware revealed during his testimony, and questioning by the prosecution yesterday. Gongaware revealed that the tour started out with 10 dates, and alleges that Michael Jackson wanted to add another 21 shows which would bring the total number of anticipated concert dates to 31. Gongaware also revealed the alleged reasoning behind adding additional shows. The CEO of AEG claimed that the artist Prince had performed 21 shows at the O2 Arena, and Michael Jackson wanted to perform 10 more dates than Prince. As viewers watching the CEO of AEG testify, there are aware of the fact that Gongaware also stated that even though all the concert dates sold out, there was a number of people waiting for the opportunity to buy tickets — 250,000 people. Gongaware revealed that by the time Michael Jackson would have performed all the tour dates, 1 million people would have gone to London to watch him perform — that has never been done.
Gongaware also revealed that Michael Jackson asked specifically that Conrad Murray be his doctor while on tour in London, and the CEO explained that he had reservations and would have preferred that Jackson have a doctor in London that knew the area. He also explained that Murray was not licensed to practice medicine in London, and that Murray told him that he would take care of that detail. Gongaware also revealed that Murray asked for $5 million dollars, claiming that he would have to close down some of his clinics. The CEO then refused the proposal. He went on to explain that Michael Jackson then asked him to offer Murray $150,000 a month, which Murray agreed to. Murray was to also receive flights to and from London, and housing for himself and his family.
It is not hard to imagine the fact that a countless number of people would have loved the opportunity to see Michael Jackson perform live. The King of Pop is one of the most popular, and successful stars of all-time, if not THE most successful of all-time.
What do you think of what Paul Gongaware had to say about the This Is It tour, Michael Jackson, and Conrad Murray? What do you think of what was said about MJ allegedly wanting to perform more shows than Prince?
| https://knotmove.com/video-michael-jackson-paul-gongaware-ceo-of-aeg-talks-conrad-murray-prince/ | 528 |
The greatest gift of life is friendship. That’s why I’m blessed to have her in my life all these while. A person that have lots of place in my heart. She taught me to be patient, be thoughtful and give in when I have too. She is amazing because she always makes sense out of me through things I refuse to acknowledge with. Through her words, I learn to understand, to accept what I always don’t. She is a big sister while I’m a baby – while I’m still crawling with my hands, she is reaching out to me with hers.
When she announced getting married, I’m so happy for her however sad to know that a good friend will be away. Soon, she will be going away for a long while, the time we get together will be lesser than we have it now but that doesn’t matter as I will miss her even more. Knowing that she lead a happy life she always wants for, it is enough for me.
TMI | Happy 1st Anniversary! | b8dba0509e9d385fbf1b416b145e3a43 | 221 |
*Terrence Howard said he was so angry over being cut from a part in "The Cosby Show" that he confronted the program's famous star to vent his frustration – only to find himself briefly blacklisted in the entertainment business.
"I was 19 and had just moved to New York from Cleveland, I got on 'The Cosby Show' on my second audition ever," Howard said, according to WENN.
He explains: "I told him, 'I'm a man just like you.' He didn't like it, and the casting agent never took my calls again."
Howard says he didn't work for four years, but eventually bounced back to launch a successful acting career - landing an Academy Award nomination in 2006 for his role in "Hustle & Flow."
--------! | e7d0f2d51c5d44b60aeabd13f012985c | 160 |
Chapman Mr He was killed at Willow Grange, November 23rd, 1899. He was acting as a guide. Major General Hildyard, in his report of November 24th, 1899, stated that Mr Chapman's services were of the greatest value, his intimate knowledge of the ground alone made it possible to carry out the operations, and added: "I sincerely trust it may be found possible to bestow on his widow some mark of recognition of his distinguished service”.
Chapman A 281 Seaman Served Jan '01 to 31 May 02. | 2cbb31f3bcad6c3e766b35276e347a54 | 116 |
<issue_start><issue_comment>Title: Add superpixels support
username_0: in imgaug documentation they say, that they use skimage "slic" for function, but i can't reproduce result from imgaug function
maybe something is missed
there is things that arise with rewriting:
1. should we call new functions from imgaug-dependent ones(with "deprecated" warning) or should we completely destroy imgaug-dependent augs?
2. should we completely reproduce augmentation results of imgaug or, if this will be working faster and better, should we enhance options of usage(for example: "slic" function of skimage contains about 10 parameters, we can use them)
here picture with result for now
https://cdn1.savepice.ru/uploads/2020/12/14/eb600411f0e73d6531167d9b490483e7-full.png
passed tests and black formatting locally
<issue_comment>username_1: I'd say it's better to keep original names in the code & imports (But not in docs, he-he) and raise a warning:
```python
class Sharpen(A.ImageOnlyTransform):
def __init__(...):
....
....
class IAASharpen(Sharpen):
def __init__(...):
warnings.warn("This augmentation is deprecated. Please use A.Sharpen instead").
```
Regarding second question - whenever possible we should keep the default behavior so the sake of backward compatibility. But exposing more parameters for more granular control of the augmentation is also highly appreciated!
<issue_comment>username_2: Thank you for your help.
What version of imgaug your implementation based on?
It looks like in latest imgaug this transform works a little bit different.
<issue_comment>username_0: Yes, in my enviroment it works also different
I'm trying to figure out why
All remarks have been notified, thanks!
<issue_comment>username_2: Implemented #849 | 9656440 | 501 |
In occasion of the exhibition “Es hängt ein Pferdehalfter an der Wand (What is love)” curated by Mario Passarotto and Daniel Löwenbrück was was released the double tape compilation “36 Aus 430 Von 30“.
Mario Passarotto collected all of the 430 records which topped the German charts between 1953 and 1993, making him the owner of the most important and maybe most frightening record-collection in Germany, which is now being displayed in Berlin at Rumpsti Pumsti for the first time.
The German music record charts were established in December 1953 with the first ever Number 1 record being “Es hängt ein Pferdehalfter an der Wand” performed by Die Kilima Hawaiians. The last Number 1 record which was exclusively released on vinyl was “What is Love” by Haddaway in 1993.
The double tape compilation published by Edizioni Passarotto is a collection of audio remakes of some of the german Hits exhibited at Rumst Pumsti. There is possible to find pieces by Daniel Arnoldsson, ANY, Anemone Tube, Daniela Fromberg & Stefan Roigk, Pure, Annie Stubbs with Krista Krull, Ute Waldhausen, re-spule, Sudden Infant, Sie nannten ihn Pferd, Les Mimis, John Murphy (Shining Vril), Kutzkelina, Marcellvs L., JD Zazie, CUBOP, Krube, Parabelles, Antoine Chessex, Kirner Kerb, Ursula Peer, Wendelin Büchler, Alessandra Eramo, Ratbag, Farahnaz Hatam, Mario de Vega, Heatsick, Kakawaka, Der Tapeman, Benjamin L. Aman.
“36 Aus 430 Von 30” is limited to 80 hand-numbered copies.
| http://www.burpenterprise.com/burp/tag/ratbag/ | 410 |
<issue_start><issue_comment>Title: vSphere Self Hosted Runner connectivity issue
username_0: Recently I noticed two pipeline failures for vSphere E2E test -
https://github.com/vmware-tanzu/community-edition/actions/runs/1561258503/attempts/1
https://github.com/vmware-tanzu/community-edition/actions/runs/1561244529/attempts/1
Both with the same error
```
The self-hosted runner: vsphere-github-actions-runner lost communication with the server. Verify the machine is running and has a healthy network connection. Anything in your workflow that terminates the runner process, starves it for CPU/Memory, or blocks its network access can cause this error.
```
Not sure what went wrong in the self hosted runner machine. I checked it just now and noticed this -
```bash
Dec 10 00:34:53 github-actions-runner runsvc.sh[817843]: 2021-12-10 00:34:53Z: Job E2E vSphere Standalone Cluster Test completed with result: Abandoned
```
I haven't found more information as of now but I'll keep this issue updated with latest details and I have rerun the jobs to check if they work now and if everything is good without communication issues with self hosted runner
<issue_comment>username_0: The self hosted runner had some docker containers that were not cleaned up (deleted)
```bash
ubuntu@github-actions-runner:~/actions-runner$ docker ps
CONTAINER ID IMAGE COMMAND CREATED STATUS PORTS NAMES
6bcb633c218d projects.registry.vmware.com/tkg/kind/node:v1.21.2_vmware.1 "/usr/local/bin/entr…" 7 hours ago Up 7 hours 127.0.0.1:46547->6443/tcp tkg-kind-c6p9um3b8uslp9k3a1c0-control-plane
02988167cf00 projects.registry.vmware.com/tkg/kind/node:v1.21.2_vmware.1 "/usr/local/bin/entr…" 7 hours ago Up 7 hours 127.0.0.1:35845->6443/tcp tkg-kind-c6p9ngrb8ushhnb3d2o0-control-plane
ubuntu@github-actions-runner:~/actions-runner$
```
<issue_comment>username_0: Same error in retry - https://github.com/vmware-tanzu/community-edition/actions/runs/1561258503/attempts/2
<issue_comment>username_0: Same error in another retry - https://github.com/vmware-tanzu/community-edition/actions/runs/1561258503/attempts/3
<issue_comment>username_0: Noticed similar failure here too - https://github.com/vmware-tanzu/community-edition/actions/runs/1562684168/attempts/1 , https://github.com/vmware-tanzu/community-edition/actions/runs/1562684168/attempts/2 | 10043440 | 906 |
class AddUserIdToSubgrupo < ActiveRecord::Migration
def change
add_column :subgrupos, :user_id, :integer
add_index :subgrupos, :user_id
end
end
| 2133265 | 59 |
Terming cyber security as a "constant battle", Gupta said the entire system, including the consumer, their apps, the network and the enterprise, has to be in a state of alertness.
A senior member of BJP on Monday said there is a need for a law to regulate data privacy and maintained a lot of apps obtain information from people that they are not supposed to do and are lax in managing them. “You all know that a lot of apps take data from you which they are not supposed to. Who regulate them or set the standards for them? I think we, as a country or as the industry, have to think about it. Especially with the digital movement, I think we have no choice but to think about it,” national head of BJP’s IT Cell Arvind Gupta told reporters.
“May be there has to be a law to be thought about in the future,” he said, speaking on the sidelines of an event hosted by American lender Citi here. If not a separate law, concerns can be incorporated by amending the prevailing regulations on cyber security, he added.
Gupta was quick to stress that the Government’s IT architecture does not have any such concerns and made a special mention of Aadhaar in this regard.
Asked about findings by an international agency showing concerns on cyber safety like trolling, Gupta declined to comment, saying he has not seen the report.
He said the rate of change to digitalisation in financial transactions is “fairly good” but underscored the need for it to help in other sectors like education and healthcare.
Terming cyber security as a “constant battle”, Gupta said the entire system, including the consumer, their apps, the network and the enterprise, has to be in a state of alertness.
At the event, a public-private partnership started by Citi, aimed at finding newer digital solutions to solve real world problems across sectors, was launched.
Individuals, start-ups or large corporations will be submitting entries for the ‘Citi tech for integrity challenge’, and the final awards will be given in August after live demos, said Citi India’s head for global consumer banking Kartik Kaushik.
The initiative was first launched at the World Economic Forum meeting in Davos last month. Citi has partnered with other companies, including IBM, PwC and Wipro apart from the Government’s Electronics and Information Technology Ministry, for the programme. | https://indianexpress.com/article/india/bjp-leader-calls-for-law-to-regulate-data-privacy-4535201/ | 516 |
Rare opportunity to acquire this brick home in prime location opposite shops and minutes walk to railway station. This brick home is right in the Centre of Quakers Hill would suit an astute investor, home occupier or potential redevelopment Opportunity (Subject to council approval) This property offers all the right ingredients from an awesome position, location & aspect. The property is zoned R2 Low density residential and has a prized 20 metre frontage presenting a great opportunity to renovate or re-develop. (subject to council approval).
Ideal for entertaining with large pergola surrounded by fruit trees. If you are into gardening you will feel like you have bought a nursery.
Perfect first home or investment opportunity in an unbeatable location on approximately 550sqm parcel of land. | https://www.andrewmerton.com.au/13-douglas-road-quakers-hill-nsw-6390734/ | 154 |
A sudden medical condition, Sepsis, changed Ruth and her family’s lives overnight, and drew her into an encounter with God’s strength and providence. She shares her testimony with us.
Two years ago in April 2019, my husband, Jason who was a Physical Education teacher, called me from school and said that he wasn’t feeling well. He came down with a fever, so we just thought it was a matter of him needing to rest. But that night, we had to bring him down to Changi General Hospital, and within a few hours, we noticed that his lips were turning blue while he was in the Accident and Emergency department.
The medical team couldn’t find an oxygen reading from his extremities (fingers and toes) and started to panic, saying that he had to be admitted to the Intensive Care Unit. Shortly after that, they also had to intubate him because he couldn’t breathe. Within 24 hours of catching that fever, the doctors told us that they weren’t sure what was wrong with him. They were still investigating but urged the family (we have two kids, aged nine and seven) to get ready to say our goodbyes just in case anything happened to him.
I was shell shocked at that point because we had just talked about where we wanted to go next in our marriage and in our spiritual walk. We had plans set out. We wanted to get involved in different prayer and marriage ministries. I wondered what had happened? Was I going to lose my husband?
That evening, my mum came to visit me. She had received a vision of Jason walking down the aisle with my daughter on her wedding day. It was a relief to know that my mum had heard from God. Though I didn’t know what was ahead, it was comforting to know that God would be holding us through it all.
When Jason regained his consciousness five days later, the doctors told us that they might have to amputate some of his toes because of the oxygen loss. This was due to the blocked vessels in his fingers and toes.
I knew that God’s promises to me about Jason’s life would still come to pass, and I could trust Him.
I wasn’t prepared for this. I wasn’t prepared for the impact of that on my family. But because he was unable to make a decision, I had to be the one signing off on everything. That afternoon, I remember crying out to God, “God, how do I sign this (medical record), knowing that it will permanently affect my husband if anything happens.” I went to the airport with a friend and while we were walking around Jewel (shopping mall), we saw a rainbow right across the centre of the fountain.
It was then that God spoke. I knew that God’s promises to me about Jason’s life would still come to pass, and I could trust Him. With that, we proceeded with the first of many amputations that Jason had.
I told the kids that God was in control, and that we could look to Him because He loves us. We cried together and prayed together, and believed that God would not fail.
Jason was in hospital for four months. Every day, I would wake up thinking that all I needed was to get through the day. I needed to take care of the kids, take care of my husband, and everything else that needed to happen for the house to function. God's steadfast love became very real to me and His mercies were new every morning. I didn’t know about tomorrow but I needed grace to be victorious in the little things one day at a time.
When there were medical decisions that I had to make, I imagined myself bringing it back to God and giving it to Him, saying “God, take this."
When Jason came home, we learnt to cope as we were both emotionally beaten up by what had happened. He had difficulty moving about and questioned his role and identity as a father, a leader and a lover. One of the things we spoke about was that although he was physically unable to do certain tasks, we would treat him and respect him as head of the household and the head of the marriage. We might not do the same things, but we could do things differently, and that helped us move forward.
Our marriage has grown stronger through these circumstances because our ability to communicate has grown stronger.
Instead of roughhousing the kids, he would play board games with them or sit with them while they were doing their schoolwork. Whenever I needed to change a light bulb, he would stand below and give directions while I tried to figure it out. We learnt to embrace a new normal.
Since, he has had below the knee amputations on both legs, walks around with a prosthesis and lost some fingers. However, I’m very grateful to the Lord that he has steadily persevered in learning to walk and is able to do almost everything with occasional assistance today.
Most couples think a marriage grows stronger if you say less and avoid picking on each other. But the funny thing is that our marriage has grown stronger through these circumstances because our ability to communicate has grown stronger. We’ve learnt to tell each other when we need a timeout, when we're tired, when we're upset and when we're depressed. We've learnt to take all that and be able to communicate with each other in a very healthy way about it.
One of the things I’ve learnt is that I don’t really have to be strong. Sometimes people look at me and think “Oh, you’re so strong.” But actually, I tell them, “No, I’m so weak, and that’s the wonderful part.” When I realise how weak I am, I can see God coming through, giving strength and providing for the small things. I’ve come to witness His grace and His assurance that it's okay for me to not have it all together and go to Him for help.
Isaiah 59 talks about how God's arm is not too short to save or His ear too dull to hear. What really resonated with me is how God hears and sees everything and that He will work for the good of His people in any and every circumstance.
I feel like I've discovered a new level of rest that I've never known before. In the past we did trust God, but those were things that did not affect the core of who we were, so it seemed to have less impact. But when our core (marriage, health) was shaken, and we had no one but God to depend on, we saw God come through for us.
In a place of fear, we’ve come to witness His providence and His peace every step of the way. Knowing that He is there, we don’t have to worry about every domain and aspect of life. | https://www.cornerstoneherald.org/post/rediscovering-rest | 1,447 |
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An office building that houses a chunk of MetLife Insurance Corporation’ s operations in Tampa has sold for $43 million to a New York City real estate investment firm. The seller was Raleigh, N.C.- based Highwoods Properties Inc.. Bromley Companies team with Highwoods Properties on $72 million Midtown Tampa offices. | https://insurancenewsnet.com/topics/inn-insider | 81 |
Can I ask you a question? And record your voice.
There is a special intimacy in stopping a stranger on the street to ask him what is the first thing that he sees when he opens his eyes in the morning.
I discovered that I was good at talking to strangers when I took a job selling books door-to-door to raise money for my first trip abroad. I was so good that I left the job when I realised that I was convincing people to buy books they didn’t need and couldn’t afford.
I am collecting voices for a project that I am creating for a forum about communication in multicultural Victoria. My idea is to show the poetry emerging from the way in which different people (with different accents, from different walks of life) pass the day, in ways that are similar yet different.
After recording my immediate family to test the concept and refine the questions, I moved on to my neighborhood. Surprisingly, people were not only enthusiastic, but they took me immediately into their living rooms, sometimes insisting that I take a tour of their home.
As an audio artist, I am interested in voices not just for what they say. I search for colours, tone, mellowness, inflection, accents. And so today I went looking for voices in the city.
Being good at talking to strangers doesn’t make it any easier. How do you choose the strangers that you are going to stop? How do you approach them? What do you say?
I notice immediately the guy sitting at the corner of Elizabeth and Flinders, the sign he has in front of his crossed legs says that he is homeless. Would it be exploitative, asking him what is the first thing he sees when he opens his eyes in the morning? Would I need to give him money? Would I be paying for his answers? Would he tell me off? Would it be patronizing? I just can’t muster the courage and so I move on.
I keep on scouting the people around me, looking at strangers straight into their eyes. There is this other guy in one of the lanes, can of beer in one hand, heavy golden chain dangling on his chest. He is chatting up a girl who is playing with her phone. She doesn’t look distressed, only disinterested. I stop in front of a shop, waiting to see the reflection of the guy walking behind me, maybe I could make eye contact and see what happens. But he has gone the opposite direction.
By the time I come home, I have recorded a guy outside the State Library who might or might not work there as a cleaner; a charming Dutch gentleman who told me the magic word used to advise friends about the danger of approaching Nazis (the word translated to ‘888 stoves’, although this didn’t make to the recording as it came when the recorder was switched off). I also recorded a couple of kids, prompted by their proud mother who really wanted them to tell me that the last thing they did before going to bed was to kiss Mum (‘and Dad’) goodnight.
I am good at talking to strangers, and I have been doing it for a long time. But that doesn’t make it any easier.
| https://addressapproximate.wordpress.com/2016/01/15/can-i-ask-you-a-question-and-record-your-voice/ | 671 |
Column: Summer fun filled with deep meaning
Ben and Olivia are on a local summer swim team, and we go to practice a few mornings and afternoons a week. Olivia is 5 and is finding her first year on the swim team a great adventure.
We had some down time the other day and went over to the diving board together for the first time. She climbed up, saw how high she was over the water, and promptly announced she was not going to go off. I decided not to encourage her further, and she stepped down and told me she was going to jump off the side into the deep end of the pool.
There she went into the deep water with not a care in the world. She came up to breathe, smiled, and continued to swim until I got her out to go home. Swimming in the deep water was a breeze for her because even at 4 feet tall, she had no idea how deep the water was. She stayed on the surface and swam to the side because she knew safety rested on the wall.
As a parent, there are moments when watching children offer pause and thought. Watching Olivia in the large and deep part of the pool, a few things darted through my mind.
Encouraging kids to do things is a powerful tool to help them grow and mature. Yet, there is a great divide between encouragement and enforcement. I do not want my kids to become afraid of the water because I foolishly do something stupid and push them too far. Allowing Olivia to jump in the deep end her own way probably kept some of the good mystery in the moment when she does decide she wants to go off the board. Plus, I think there is some merit to "good apprehension" or "good fear." It may keep us out of trouble for a time when we are better suited to handle it.
Sometimes, I think parents make a mistake and try to live their childhoods again through their kids. It can happen. I am fortunate my children want to participate in a sport that brings me so much joy, but my wife and I will not force swimming on them. If they do not want to swim next year, it would be okay.
We live in a world spilling over with competition where simply the goal of winning is often put ahead of the desire for competing. Practice, hard work, integrity, and sportsmanship are much more important than just winning. More than anything, I want my children to gain positive learning experiences from the activities they do.
As coaches and parents, we do make mistakes. I have certainly made a few. One of the best pieces of advice I have ever gotten about fatherhood and coaching is to admit to my children when I make mistakes so they can see the honest character in being accountable and responsible. I heard a parent say once that when he made a mistake, he sat on his son’s bed and apologized and explained why he was wrong. What a great way for an older man to teach a younger kid about character. Those principles could certainly help a lot of our leaders today if they were practiced more.
Nothing happens without the power of family. My wife and I recently attended a retreat where we had the opportunity to be with other couples who experience the challenges of family life and coaching. I sat in some sessions and was comforted knowing some of the struggles my wife and I face are experienced by other families from different parts of the state. We laughed and cried together in an effort to strengthen and encourage one another to be the backbones of our families, but also to the children we teach and mentor each day. It was an awesome experience.
Sometimes we are all in deep water and need the blessings of comfort and encouragement. There are fewer things more uplifting than helping others find their way out of their troubles and reach safety once again.
The deep end can be different for each of us. Life can often sweep us into a whirlpool of doubt and into the deep waters of the soul. We can be blinded by many things and challenged in so many ways.
The Bible instructs us in the first book of Peter to cast all of our care upon the Lord because he cares for us. At the edge of the deep, he is our ultimate comfort and strength. His words keep us afloat and ready to face the next challenge. His careful watch confirms the promise: We’re going to reach the wall safely. | e5b21710617051a1756bfb2d69e0f119 | 901 |
Translate "These Rigid Hull Inflatable Boats (RHIBs) are designed as a fast rescue or patrol boat, and can be deployed either from a trailer or from a shipboard davit." to French?
Servant au sauvetage et à la patrouille, ces embarcations sont conçues pour être déployées à partir d’une remorque ou d’un bossoir. | 78fb6e61d7438ea2379f3484de079b72 | 100 |
so me and my best friend when out to a cub this weekend, but when we came there both of us weren't in a super party mood, so i decided to talk to two guys that i saw were looking at us, because cute guys are always fun ;). After introducing myself i introduced my friend to the other guy (i didn't care who i was talking to because i just wanted to have a friendly chat). I found very quickly that the guy i was talking to was interested, but i wasnt, and i think he found out quite quickly, so he and his friend left.
But today my sister was missing, she had gone to a guys place to have sex, but she didn't bring her phone and she didn't tell anyone where she was. I had the number to one of the guys i had been talking to, so i sendt him a message asking him if he knew where my sister was ( i thought his friend was with her), He said he didn't talk to my sister at all, but sendt me his friends number and his name. So i seach for the guy on Facebook and sendt him a message asking if he knew where my sister was, he responded, and i quote "what?". So i explained the situation, but he hasent replied yet.
Anyway, my "problem" is that i think he's really cute. I want to make a move, but im not sure if he is intresed, like i talked to him the night we went out, but i was mainly talking to his friend, just because he was closer to me. I dont know what to say or do! So how can i "make a move", im attracted to him, but i have never suceeded with guys i find attarctive.
Most Helpful Girl
Wait, have you found your sister yet?
Is this the guy your sister supposedly left with, to have sex with?
THAT is the guy you're now interested in and wanting to make a move on?10|10|0
Ahhh, gotcha, okay.
I was a little weirded out for a second, haha!
Okay well, you messaged him and he's not responding at all after saying "What?"
That's definitely not a good sign, but it could be that he's not interested, it could be that he was caught off guard by the questioning and how you got his information, or it could be that he doesn't really remember you much so he isn't sure how to proceed.
No, the guy im intrested in is the friend of the guy i talked to but wasn't interested in. Yes, i found her, and she went without someone else. Im not that weird lol | 46bc94c40073e6ed86a7576247e26bb1 | 564 |
Raffles, Auction and Lots of Chili To Help Raise Money For Fairgrounds
January 23, 2003
Raffles, Auction and Lots of Chili To Help Raise Money For Fairgrounds
While the forecast is calling for polar conditions outdoors the action should be hot at the Memphis VFW Saturday, January 25. Hundreds of dollars in prizes will be auctioned and raffled off as part of the Scotland County Fairboard's fundraiser for the new cook shack and restrooms at the fairgrounds.
If the prizes and the $1,000 cow-chip bingo isn't warm enough for you then try the group's first-ever Chili Cook Off that will feature entries from cooks across the community. Entrants simply need to bring a $2 entry fee and one gallon of chili for the "celebrity" judges, Rick Fischer of KMEM, Jim McClintic, Lucas Mauck, Tom Deberry and Kevin Eggleston. Whatever's leftover from the gallon "samplers" will be auctioned off to the highest bidder.
With that crew of judges, the crowd is fortunate it doesn't have to count on winning the chili auctions in order to be fed that evening. An all you can eat soup and pie supper will be held from 5:00 p.m. to 8:00 p.m. at the V.F.W. The cost is only $5 with all the proceeds going toward the fair board project.
Raffles will be held every half hour beginning at 5:30 p.m. giving away such items as a $100 savings bond from Community Bank of Memphis, two $50 Gift Certificates from J's Foods, and numerous other gift certificates from Pizza Hut, Scotland County Lanes, Gas & More, K&M Automotive, The Social, The Catfish Place, Nishida Company & Jim's Upholstery, Beads Lady Nishida Co., Hopkins Lumber and Arbela 4-Corners.
Other raffle items will include gifts from Rose Hardware, Gerth & Basket, Payne Funeral Chapel, Town Peddler, Countryside Flowers, The Flower Garden, Brock Station, MCM Savings Bank, Dale Racing, Kountry Konnection, Farm & Home, and Scotland County Speedway.
If the chili, pie and raffles galore aren't enough excitement then stick around for the auction set to start at 7:00 p.m.
Big ticket items on the sale bill will include $50 gift certificates from K&M Automotive and J's Foods, and a Gold Card season pass for the Scotland County Speedway.
But that's just the tip of the iceberg with more than 20 items to be sold by auction for the fundraiser. Other auction donors include Pepsi-Cola Memphis Bottling, Hauk Seed, & Feed, Audrey Glass, Richard Clark, Cowell & Cowell Feed, MFA Farmer's Elevator, Trueblood Racing, Racemart, Cunningham Fertilizer, Monsanto, Memphis Lumber, Bank of Kirksville, Struble Antiques, Phil Aylward, Ferrellgas, Kountry Konnections and Tim Slayton Polaris.
With all the food and entertainment, the question is not whether the evening will be enjoyed by all, but instead is how in the world are they going to get all this entertainment packed into just three hours? | 00f7b27cfd5574a37cc49b2b9bdd1182 | 689 |
Triodos Investment Management finances and invest in companies, institutions and projects that add cultural value and aim to benefit people and the environment. Triodos Investment Management does this with the support of investors who want to encourage socially responsible business and a sustainable society. Triodos Investment Management (Triodos IM) manages Socially Responsible Investment (SRI) funds and impact funds. The SRI funds enable clients and Private Banking to invest in listed companies with high sustainability performance. Through the impact funds Triodos IM directly invests in sustainable companies and projects.
To assess investment proposals, our relationship managers and fund managers refer to our Business Principles in the first instance. Then, the Lending Criteria which specify how Triodos IM’s vision and mission are translated into investment practice are applied. Our Minimum Standards & Exclusions set out the absolute minimum requirements that Triodos Investment Management applies for its investment activities.
Triodos Investment Management takes measures to mitigate conflicts of interest which may occur from the different roles and responsibilities it has towards the managed funds, the funds investors and the companies in which we invest. We have clear procedures in place containing rules covering situations where (potential) conflict of interests could occur. These procedures are described in our ‘Triodos Policy on Confidential Information, Chinese walls, and Conflicts of Interest’.
Furthermore Triodos IM commits itself to the DUFAS Principles of Fund Governance, which include several provisions on Conflicts of Interest. In line with these provisions and as far as appropriate, a segmentation between investment decisions, settlement of transactions, administration of transactions and control is in place to prevent (potential) conflicts of interests. Triodos IM installed “Chinese walls” to manage the flow of price-sensitive information and other confidential market information. There is an organizational, physical and personnel segregation between the business units to the extent that this is reasonably necessary, relative to their activities. Appropriate information-sharing barriers are in place to prevent dissemination of sensitive market information. No price-sensitive or confidential market information is exchanged between business units other than is required to effectively carry out their work.
Triodos co-workers can be appointed to a management or supervisory position of a company which is financed by one of our funds, except in case of Triodos SICAV I. In case of an appointment, the appointed co-workers is not allowed to deliberate or participate on any decision where there is a conflict of interest.
It is possible that companies and projects which are financed by our funds also invest in a Triodos fund. Triodos co-workers are not allowed to take part on such investment decisions in order to prevent a conflict of interest. In relation to financed companies, Triodos Investment Management has provisions in place which prevent Triodos co-workers to use confidential information for any other purpose then for which it has been acquired.
For investments in the stock markets, the dataprovider provides bi-weekly overview of alerts, relating to any ESG controversies. Alerts are picked up within two weeks. In case of serious concerns companies are placed under review. If a company is removed from the universe, the asset manager has to sell the securities within six months.
For direct investments the fund manager monitors the investments through periodical reviews and as part of the ongoing long-term relationships. In case of concerns immediate contact takes place. | https://reporting.unpri.org/surveys/PRI-reporting-framework-2018/B9234938-C041-4D9C-A04E-BF85A86FC59A/bf735de92be04caa8c32fcbc25cbdd2c/html/2/?lang=en&a=1 | 698 |
Online Course 2
Theme: Public Service Supply Chain in Post Covid 19 Environment: Challenges and Opportunities
Date: 04th August 2020
Time: 1345 to 1745 Hrs
Registration Link:
Target Audience:
- Government – District Authorities, State/ Central Line Ministry Officials, Directors, Joint Directors & Asst. Directors/ Project Directors /Project Officers
- Non-Government Organizations
- Corporate social responsibility Foundations
- Supply Chain Executives
- Public Service Managers
- Elected representatives
- Faculty Members / Academicians
- Students & Research Scholars
Host: Administrative Staff College of India (ASCI) and Centre for Innovations in Public Systems (CIPS)
Background
The spread of Covid-19 is an epidemic affecting hundreds of thousands of people in the country and world at large, with significant economic implications to linger for months to come. Working through Covid-19 pandemic situation will require creative strategies to enable on-the-ground decision-making and provide leaders with access to up-to-date information. Mitigation plans for crisis-related risks must be practical and accessible, allowing public servants and decision makers to make smart decisions quickly. A multifaceted approach that addresses the public services specific challenges will help determine the best way of managing the public service supply chain (PSSC) and ensuring its resilience. In formulating a response strategy, authorities need to consider the following:
- Position sourcing and procurement as a strategic tool to mitigate PSSC disruptions
- Identify and implement unconventional sourcing strategies for critical services and essential products
- Develop a go-forward plan for modernization of procurement procedures to address PSSC resilience
In response to the current Covid-19, the immediate focus needs to be on improving visibility to supply chain impact. If we fail to visualize the potential supply chain problems across end-to-end supply chain then we cannot adequately prevent or manage them. Getting this extended supply chain visibility to minimize the Covid-19 impact will likely require a more integrated approach than what organizations have used in the past.
Learning Objectives
- To enhance the participants' understanding of concepts of managing Public Service delivery with a Supply Chain perspective
- To strengthen the efforts of stakeholders implementing Public Service Supply Chain
- To prepare the stakeholders to rebound and come-out from the Covid-19 impact in a quick time
Schedule
Coordinator(s):
- Prof. Vilas Shah, This email address is being protected from spambots. You need JavaScript enabled to view it.
- Prof. BVN Sachendra, This email address is being protected from spambots. You need JavaScript enabled to view it.
- Prof. Kali charan Sabat, This email address is being protected from spambots. You need JavaScript enabled to view it. | 0a26e3c14ee2aa77430c18e0112c5a21 | 581 |
."
Carney's Morgan DuPont (27:05) and Samantha Charlier (27:10) were thrid and fourth respectively.
North Central D-3 Invitational
At Wilson
Boys.
"Success is always nice because these kids work so hard," said Carney coach Jake Polfus. "This is kind of shocking because we have only two girls, although they ran real good today. This is a nice prize for them to get."
This victory took place just 24 hours after the Carney boys won the Goodman-Pembine Invitational at Dunbar, Wis.
"The boys ran real well at Dunbar," said Polfus. "They're showing improvement. They're also working hard in practice and that's all you can ask for. More people are getting medals and they're gaining confidence. This has been a big week for us."
The North Central boys won Wednesday, however, with 43 points. The Jets ran without freshman Jon King, who's battling a respiratory ailment.
"I'm happy with these kids today," said North Central coach Jerry Root. "Here's where you need to have a little depth and a freshman (Tyler Bentley) stepped up for us. These kids were thrilled to get a trophy. This is a great boost for them. If they work hard, there will be more trophies for them."
Superior Central was runner-up at 60, followed by defending champ Carney 63, Marquette North Star Academy 75 and Big Bay 116.."
Carney senior Dionte Blahnik, who was crowned champion a year ago, was runner-up this time at 18:18, followed by North Central freshman Seth Polfus (18:32) and sophomore Bryce Holle (19:32) and North Star's John-Henry Kibil (19:40).
"It was hard today, although I really wasn't that tired," said Blahnik, who won at Dunbar Tuesday. "I just used this as a good, hard training run for Saturday (Stephenson Invitational). I was trying to win two in a row, but it didn't happen."
North Star's Darren Kastella was unable to finish after being attacked by hornets and getting stung four times in the head early in the race. The eighth-grade harrier, who isn't allergic to bee stings, appeared to be okay.
600 Ludington St. , Escanaba, MI 49829 | 906-786-2021
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Ravensburg is a town in Upper Swabia in Southern Germany, capital of the district of Ravensburg, Baden-Württemberg.Ravensburg was first mentioned in 1088. In the Middle Ages, it was an Imperial Free City and an important trading centre. The "Great Ravensburg Trading Society" (Große Ravensburger Handelsgesellschaft) owned shops and trading companies all over Europe.The historic town centre is still very much intact, including three town gates and over 10 towers of the medieval fortification. "The all-white Mehlsack (Flour Sacks) is a tower marking the Altstadt’s southern edge. A steep staircase leads up to the Veitsburg, a quaint baroque castle."The town's most popular festival is the "Rutenfest" in mid year.HistoryRavensburg was first mentioned in writing in 1088. It was founded by the Welfs, a Frankish dynasty in Swabia who became later Dukes of Bavaria and Saxony and who made the castle of Ravensburg their ancestral seat.By a contract of inheritance, in 1191 the Hohenstaufen Frederick Barbarossa acquired the ownership of Ravensburg from Welf VI, Duke of Spoleto and uncle of both Frederick Barbarossa and Henry the Lion. With the death of Conradin 1268 in Naples the Hohenstaufen line became extinct. Their former estates became imperial property of the Holy Roman Empire. Like many other cities in Swabia, at the end of the 13th century Ravensburg became an Imperial Free City in 1276. Ravensburg is in Baden-Wurttemberg. Use our Germany vacation builder tool to plan your trip to Ravensburg and other destinations in Germany.
| http://trip-planner.hostelcelica.com/germany/ravensburg-trip-planner | 367 |
The Dixie is something of a yoof boozer, albeit a lively and pleasant one, to the right of the building and a pizza restaurant to the left with staff dotting between the two.
Just two beers on: Jennings Knight Porter, which was in good shape and Marstons Burton Bitter.
Not the ale range of the Red Lion next door but I'd have a squint in the window to see if there was anything on which appealed.
The original building has been split in half,to the left an Italian restaurant,the the right an open plan bar room with some exposed brickwork but contemporary in decor.There were a few round high tables close to the bar and three large banquettes to the side with a real fireplace at the far end below a large flat screen,with a logo for a music channel which provided the muzak.Lively and the haunt of a youngish crowd but all very well behaved.A solid drinking atmosphere also encouraged a few town crawlers from the older generation.
Three handpumps ,my Jennings Knight Porter was fresh and very good,and at £3.20 a sensible price compared with the pub nearby.
More of a boozer,with diners going next door and both being served by the busy barmaids this place would always get a visit from me when in Bosworth.
A decent looking pub from the outside but once inside the pub has been done up and spoilt in my opinion,there are leather type seats which look a bit naff.
There were two real ales on the bar i tried Marstons Pedigree which was fairly decent there was also Marstons Bitter on which i did'nt try.
| https://www.pubsgalore.co.uk/pubs/37087/ | 354 |
Custom Blog Site Template
If you are using the out of the box SharePoint blog site and want to change the look and feel away from the ‘boxy’ SharePoint look this post is for you.
During the process of customising this blog I have created a master page and two CSS files that can be used to give a SharePoint blog a ‘cleaner’ look and feel. At the moment it looks like this:
All that is needed to transform an existing SharePoint blog to the above is one master page file and related CSS and image files. I have provided these files in a zip folder for download so you can apply this design to existing blogs. I have also created a site template file (.stp) that can be installed so new blog sites can be created with the design already applied.
Installing the design on an existing blog site
To get the site up and running on an existing blog site simply copy the sample files to the master page gallery of your blog site.
This can be done by selecting site actions > site settings > galleries – master pages > upload multiple files and selecting the five files contained in the zip folder.
Note that this will overwrite the existing master page and customise the site from the site definition. If you ever want to return the site back to the original state simply select site actions > site settings > reset to site definition > reset all pages in this site to site definition version. You can also delete the leftover image and CSS files in the master page gallery to completely remove all the custom template elements.
Installing the site template
To install the custom blog template so that you can create new blog sites with this design you need to add the site template file (.stp) to the site template gallery.
This can be done by navigating to the top level site in the site collection and selecting site actions > site settings > galleries – site templates > upload and selecting the .stp file contained in the above zip folder.
To create new sites based on this template simply select site actions > create > sites and workspaces, then enter a title, description and url and click on the custom tab under template selection and select Blog – Simple Gradient.
About the design
To create this design I have customised the default.master by removing all style/layout information and then adding in div tags to mark-up the elements. I have then used a style sheet named styles.css to style the elements contained in the master page. I have also used another style sheet named sharepointstyles.css to override the style sheet provided by SharePoint (core.css).
In a later post I will provide detailed instructions on how to recreate and extend your this template. You can also expect a much richer set of blog features with the release of an enhanced blog edition by the CKS:EBE team that I am part of. We are hoping to get something out early next month so watch this space…
Yep. Same issue. Add comments is missing. Anyone know how to fix this?
Russ
13 Nov 08 at 2:34 pm
Any resolution to this: "adding comments is missing from the blogs". We have the same issue. Thanks.
nyalex
3 Oct 08 at 4:54 pm
Is there any where else I can get the files from ?? the BlogFiles-SimpleGradient.zip doesn't link here.
dan
11 Sep 08 at 3:57 am
we've been creatign blog sites based on a template for a while with no issues. Howvere recently we now have the issue mentioned above, in that the comments form is missing. The template on which the site is created hasn't changed, but we have recently applied hotfix and this is our suspected 'guilty party'. Any news on whether this was ever resolved for you?
Donna
18 Jul 08 at 10:49 am
I see that the form for adding comments is missing from the blogs created from your template. I have encountered the same problem on our SharePoint site.
Any ideas?
Vincent
26 Oct 07 at 11:48 pm
I have the need to re-create the SharePoint Blog "Post/Comment" functionality by creating template Lists that accomplish the same thing as the Blog template "site" does. As we have the need for blogs within existing team sites but we can NOT have them be separate 'sites' just because we need to add blog functionality.
Do you know any articles that explain how to duplicate that Blog Post/Comment linking functionality just into List templates?
Thanks!
MSILinda
30 Apr 09 at 4:57 pm
Was there ever any resolution to the comments form missing from blogs created from a custom template? I am completely missing the add comments form. How do i get it back?????
Test
10 Apr 09 at 8:28 pm
I have the same problem, I like the template, but I think the listviewwebpart for comments is not in the post.aspx file
Lynchy
26 Feb 09 at 2:36 pm
I need threaded comments in my sharepoint blog, is any developed custom template for this.
Advance Thanks
Jenkins
1 Jun 10 at 9:37 am
@Jenkins not that I’m aware of unfortunately
Ari Bakker
14 Dec 10 at 6:21 pm | 0a518a554a8daf20fe97ca4169c406c6 | 1,101 |
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