Datasets:

siddharthtumre

/

jnlpba-split

like 0

[ "Analysis", "of", "GR", "chimeric", "receptors", "containing", "the", "potent", "VP16", "and", "E1A", "viral", "transactivation", "domains", "in", "place", "of", "the", "GR", "N", "terminus", "revealed", "that", "even", "low", "level", "expression", "of", "these", "receptors", "resulted", "in", "both", "enhanced", "steroid", "sensitivity", "and", "MMTV", "induction", ",", "thus", "supporting", "a", "role", "for", "transactivation", "in", "apoptosis", "." ]

[ 0, 0, 9, 10, 10, 0, 0, 0, 1, 2, 2, 2, 2, 2, 0, 0, 0, 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Treatment", "with", "okadaic", "acid", "resulted", "in", "a", "striking", "increase", "in", "TNF-alpha", "mRNA", "transcripts", "within", "1", "h", "of", "stimulation", "and", "large", "amounts", "of", "TNF-alpha", "were", "released", "into", "the", "culture", "media", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0 ]

[ "Tumor", "necrosis", "factor-alpha", "mRNA", "accumulation", "in", "human", "myelomonocytic", "cell", "lines", "." ]

[ 3, 4, 4, 4, 0, 0, 5, 6, 6, 6, 0 ]

[ "Some", "criteria", "which", "can", "be", "used", "to", "define", "steroid-resistant", "bronchial", "asthma", "are", "listed", "here", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Immunoprecipitation", "and", "electrophoretic", "mobility", "shift", "analysis", "revealed", "that", "tyrosine", "phosphorylation", "of", "JAK2", "and", "activation", "of", "STAT5", "were", "induced", "upon", "stimulation", "with", "hIL-5", "in", "all", "three", "cell", "types", ",", "while", "STAT1", "activation", "was", "only", "observed", "in", "eosinophils", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 9, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 7, 0 ]

[ "Confirmation", "of", "a", "model", "." ]

[ 0, 0, 0, 0, 0 ]

[ "One", "base", "pair", "change", "abolishes", "the", "T", "cell-restricted", "activity", "of", "a", "kB-like", "proto-enhancer", "element", "from", "the", "interleukin", "2", "promoter", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0, 0, 1, 2, 2, 0 ]

[ "Interestingly", ",", "we", "consistently", "observed", "30", "%", "less", "RT-PCR", "product", "derived", "from", "the", "small", "t", "allele", "mRNA", "in", "steady", "state", ",", "a", "finding", "which", "also", "speaks", "against", "a", "higher", "stability", "of", "the", "small", "t", "allele", "mRNA", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 3, 4, 4, 4, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 4, 4, 0 ]

[ "NF-Y", "is", "formed", "by", "three", "subunits", ",", "A", ",", "B", ",", "and", "C", ",", "all", "of", "which", "are", "necessary", "for", "DNA", "binding", "." ]

[ 9, 0, 0, 0, 0, 9, 0, 9, 0, 9, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Human", "herpesvirus", "6", "variant", "A", ",", "but", "not", "variant", "B", ",", "infects", "EBV-positive", "B", "lymphoid", "cells", ",", "activating", "the", "latent", "EBV", "genome", "through", "a", "BZLF-1", "-dependent", "mechanism", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 6, 6, 0, 0, 0, 1, 2, 2, 0, 0, 9, 0, 0, 0 ]

[ "CD40", ",", "but", "not", "lipopolysaccharide", "and", "anti-IgM", "stimulation", "of", "primary", "B", "lymphocytes", ",", "leads", "to", "a", "persistent", "nuclear", "accumulation", "of", "RelB", "." ]

[ 9, 0, 0, 0, 0, 0, 9, 0, 0, 7, 8, 8, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0 ]

[ "Because", "the", "-180", "site", "is", "not", "required", "for", "trans-activation", ",", "it", "was", "possible", "to", "confirm", "by", "mutation", "in", "the", "normal", "mouse", "IL-2", "enhancer", "that", "this", "site", "is", "absolutely", "essential", "for", "anergy", "induction", "." ]

[ 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Induction", "of", "HL-60", "and", "U-937", "cell", "differentiation", "into", "monocytes/macrophages", "by", "IFN-gamma", "or", "PMA", "results", "in", "a", "dephosphorylation", "and", "consequent", "activation", "of", "4E-BP1", "." ]

[ 0, 0, 5, 0, 5, 0, 0, 0, 7, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0 ]

[ "Precise", "deletion", "of", "the", "exons", "suggests", "that", "they", "are", "alternatively", "spliced", "transcripts", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Since", "one", "of", "the", "two", "X", "chromosomes", "is", "randomly", "inactivated", "at", "an", "early", "stage", "of", "female", "embryonic", "development", ",", "X-linked", "markers", "have", "been", "used", "to", "study", "the", "origin", "and", "development", "of", "various", "neoplastic", "disorders", "in", "affected", "heterozygous", "women", ";", "clonality", "assays", "have", "provided", "a", "useful", "tool", "to", "the", "understanding", "of", "the", "mechanisms", "underlying", "the", "development", "of", "neoplasia", "." ]

[ 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Surprisingly", ",", "even", "p65", ",", "but", "not", "c-rel", ",", "was", "phosphorylated", "after", "induction", "in", "vivo", ",", "suggesting", "that", "TNF-alpha", "selectively", "activates", "only", "specific", "NF-kappa", "B", "heteromers", "and", "that", "modifications", "regulate", "not", "only", "I", "kappa", "B", "molecules", "but", "also", "NF-kappa", "B", "molecules", "." ]

[ 0, 0, 0, 9, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 0, 0, 9, 10, 0, 0 ]

[ "Conversion", "of", "E2", "to", "E1", "was", "upregulated", "within", "24", "hours", "when", "HL60", "cells", "were", "treated", "with", "either", "all-trans", "retinoic", "acid", "or", "D3", "at", "doses", "that", "induce", "their", "differentiation", "toward", "neutrophils", "or", "monocytes", ",", "respectively", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 0, 7, 0, 0, 0 ]

[ "The", "increased", "levels", "of", "these", "proteins", "correlated", "with", "increases", "in", "the", "amounts", "of", "their", "mRNAs", "during", "LPS", "activation", "of", "THP-1", "cells", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 0, 0, 0, 0, 5, 6, 0 ]

[ "The", "effect", "of", "transmembrane", "signaling", "of", "T", "cells", "with", "ionomycin", ",", "and/or", "sn-1", ",", "2", "dioctanoyl", "glycerol", ",", "was", "also", "determined", "." ]

[ 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Previously", ",", "we", "have", "shown", "that", "TAL1", "and", "the", "LIM-only", "protein", "gene", "(", "LMO", ")", "are", "regularly", "coactivated", "in", "T-cell", "acute", "lymphoblastic", "leukemia", "(", "T-ALL", ")", "." ]

[ 0, 0, 0, 0, 0, 0, 9, 0, 0, 1, 2, 2, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "In", "turn", ",", "assembly", "of", "this", "complex", "mediates", "the", "enzymatic", "activation", "of", "the", "p21-activated", "protein", "kinase", "1", "and", "facilitates", "actin", "polymerization", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 0, 0, 9, 0, 0 ]

[ "A", "solution", "hybridization", "assay", "was", "used", "for", "quantitative", "analysis", "of", "GR", "mRNA", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 0 ]

[ "Physiological", "concentration", "of", "estradiol", "inhibits", "polymorphonuclear", "leukocyte", "chemotaxis", "via", "a", "receptor", "mediated", "system", "." ]

[ 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0 ]

[ "Secreted", "TNF-alpha", "mediated", "the", "enhancement", "of", "nuclear", "factor", "kappa", "B", "(", "NF-kappa", "B", ")", "and", "activator", "protein-1", "(", "AP-1", ")", "binding", "activity", ";", "in", "fact", ",", "the", "triggering", "of", "HLA-DR", "antigens", "in", "the", "presence", "of", "antihuman", "TNF-alpha-neutralizing", "antibodies", "did", "not", "upregulate", "NF-kappa", "B", "and", "AP-1", "." ]

[ 0, 9, 0, 0, 0, 0, 9, 10, 10, 10, 0, 9, 10, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 9, 10, 10, 0, 0, 0, 9, 10, 0, 9, 0 ]

[ "At", "the", "2", "microM", "concentration", ",", "eosinophil", "cationic", "protein", ",", "eosinophil-derived", "neurotoxin", ",", "and", "eosinophil", "peroxidase", "did", "not", "stimulate", "significant", "levels", "of", "IL-8", "production", "." ]

[ 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 9, 0, 0 ]

[ "To", "examine", "the", "potential", "effects", "of", "stress", "on", "TH1/TH2", "balance", ",", "we", "studied", "the", "ability", "of", "three", "prototype", "stress", "hormones-dexamethasone", "(", "a", "synthetic", "glucocorticoid", ")", "and", "the", "catecholamines", "norepinephrine", "and", "epinephrine-to", "alter", "the", "production", "of", "IL-12", "(", "p70", ")", "and", "IL-10", "induced", "by", "bacterial", "lipopolysaccharide", "(", "LPS", ")", "in", "human", "whole", "blood", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 9, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Among", "these", "hypersensitive", "sites", ",", "two", "transcriptional", "control", "elements", "were", "found", ",", "one", "in", "the", "first", "intron", "of", "the", "GATA-3", "gene", "and", "the", "other", "between", "8.3", "and", "5.9", "kilobases", "5", "'", "from", "the", "GATA-3", "transcriptional", "initiation", "site", "." ]

[ 0, 0, 1, 2, 0, 0, 1, 2, 2, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 1, 2, 0, 0, 0, 1, 2, 2, 2, 2, 0, 0, 0, 0, 1, 2, 2, 2, 0 ]

[ "Induction", "of", "IL-5", "mRNA", "upon", "TCR", "and", "IL-2R", "stimulation", "was", "totally", "inhibited", "by", "dexamethasone", "." ]

[ 0, 0, 3, 4, 0, 9, 0, 9, 0, 0, 0, 0, 0, 0, 0 ]

[ "Previous", "studies", "have", "also", "demonstrated", "a", "role", "for", "endogenous", "ceramide", "release", "in", "Fas-mediated", "apoptosis", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Accordingly", ",", "we", "studied", "the", "role", "of", "NF-kappaB", "in", "germline", "Cepsilon", "transcription", "by", "using", "two", "human", "Burkitt", "'s", "lymphoma", "B", "cell", "lines", ",", "DND39", "and", "DG75", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 9, 0, 1, 0, 0, 0, 0, 0, 5, 6, 6, 6, 6, 6, 6, 0, 5, 0, 5, 0 ]

[ "PG490", "inhibits", "the", "induction", "of", "DNA", "binding", "activity", "at", "the", "purine-box/antigen", "receptor", "response", "element", "(", "ARRE", ")", "/nuclear", "factor", "of", "activated", "T-cells", "(", "NF-AT", ")", "target", "sequence", "but", "not", "at", "the", "NF-kappaB", "site", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 0, 0, 0, 0, 1, 2, 0 ]

[ "The", "TCF-1", "gene", "encodes", "a", "putative", "transcription", "factor", "with", "affinity", "for", "a", "sequence", "motif", "occurring", "in", "a", "number", "of", "T-cell", "enhancers", "." ]

[ 0, 1, 2, 0, 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0 ]

[ "This", "protein", "is", "most", "similar", "to", "the", "105-kDa", "precursor", "polypeptide", "of", "p50-NF-kappa", "B", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0 ]

[ "Electrophoretic", "mobility", "shift", "assays", "indicated", "that", "the", "-230", "GATA-1", "site", "has", "a", "relatively", "low", "affinity", "for", "GATA-1", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0, 0, 0, 0, 0, 0, 9, 0 ]

[ "However", ",", "there", "are", "other", "effects", ",", "such", "as", "the", "early", "activation", "of", "protein", "kinase", "C", ",", "which", "are", "probably", "derived", "from", "the", "production", "of", "primary", "DNA", "breakage", "by", "some", "anti-", "topoisomerase", "drugs", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0 ]

[ "Further", ",", "the", "level", "of", "nuclear", "proteins", "capable", "of", "binding", "to", "the", "NF-kappa", "B", "sites", "in", "activated", "T", "cells", "increased", "in", "response", "to", "DM", "." ]

[ 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 1, 2, 2, 0, 7, 8, 8, 0, 0, 0, 0, 0, 0 ]

[ "Moreover", ",", "we", "confirmed", "that", "the", "ectopic", "expressions", "of", "Smad6", "and", "Smad7", "inhibited", "the", "hBMP-2", "-induced", "Smad1/Smad5", "phosphorylation", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 9, 0, 0, 9, 0, 9, 0, 0 ]

[ "Sublethal", "levels", "of", "oxidative", "stress", "stimulate", "transcriptional", "activation", "of", "c-jun", "and", "suppress", "IL-2", "promoter", "activation", "in", "Jurkat", "T", "cells", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 1, 2, 0, 0, 5, 6, 6, 0 ]

[ "In", "this", "study", "we", "demonstrated", "that", "a", "mutant", "Escherichia", "coli", "endotoxin", "lacking", "myristoyl", "fatty", "acid", "at", "the", "3", "'", "R-3-hydroxymyristate", "position", "of", "the", "lipid", "A", "moiety", "retained", "its", "full", "capacity", "to", "coagulate", "Limulus", "amoebocyte", "lysate", "compared", "with", "the", "wild-type", "E.", "coli", "endotoxin", "and", "markedly", "stimulated", "the", "activation", "of", "human", "monocyte", "nuclear", "factor-kappaB", "and", "the", "induction", "of", "Mn", "SOD", "mRNA", "and", "enzyme", "activity", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 0, 0, 0, 0, 3, 4, 4, 0, 0, 0, 0 ]

[ "All", "factors", "are", "induced", "in", "the", "nuclei", "of", "T", "cells", "upon", "activation", "with", "mitogens", "but", "not", "with", "exogenous", "IL-2", "growth", "factor", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 9, 0, 0, 0, 9, 10, 10, 10, 0 ]

[ "Bcl6", "mutation", "was", "found", "in", "13", "of", "24", "(", "54", "%", ")", "clones", "from", "the", "germinal", "centre", "but", "only", "in", "1", "of", "24", "(", "4", "%", ")", "clones", "from", "the", "naive", "B", "cells", "of", "the", "mantle", "zone", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 8, 0, 0, 0, 0, 0 ]

[ "Thymic", "dendritic", "cells", "(", "DC", ")", "mediate", "negative", "selection", "at", "a", "relatively", "late", "stage", "of", "the", "T-cell", "developmental", "pathway", "." ]

[ 7, 8, 8, 0, 7, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "PDTC", "or", "N-acetylcysteine", "dose", "dependently", "reduced", "TNF-induced", "VCAM-1", "but", "not", "ICAM-1", "surface", "protein", "(", "also", "in", "human", "umbilical", "arterial", "endothelial", "cells", ")", "and", "mRNA", "expression", "(", "by", "70", "%", "at", "100", "mumol/L", "PDTC", ")", "in", "HUVECs", "as", "assessed", "by", "flow", "cytometry", "and", "polymerase", "chain", "reaction", "." ]

[ 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 9, 10, 10, 0, 0, 0, 7, 8, 8, 8, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "These", "specific", "proteases", "are", "coordinately", "expressed", "and", "were", "present", "exclusively", "in", "the", "minus", "U937", "clones", ",", "but", "not", "in", "the", "plus", "clones", ",", "as", "demonstrated", "in", "the", "case", "of", "cathepsin", "G", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 6, 0, 0, 0, 0, 0, 5, 6, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0 ]

[ "Elevated", "cyclic", "AMP", "inhibits", "NF-kappaB", "-mediated", "transcription", "in", "human", "monocytic", "cells", "and", "endothelial", "cells", "." ]

[ 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "The", "implication", "of", "mouse", "AML1/PEBP2", "alpha", "B", "expression", "in", "hematopoietic", "cells", "other", "than", "those", "of", "T-cell", "lineage", "is", "discussed", "in", "relation", "to", "myeloid", "leukemogenesis", "." ]

[ 0, 0, 0, 0, 9, 10, 10, 0, 0, 7, 8, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Interleukin-4", "is", "an", "immunomodulatory", "cytokine", "which", "plays", "a", "central", "role", "in", "the", "regulation", "of", "allergic", "and", "atopic", "immune", "responses", "." ]

[ 9, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Interestingly", ",", "treatment", "of", "purified", "HIV-TF1", "by", "phosphatase", "greatly", "reduced", "its", "DNA-binding", "activity", ",", "suggesting", "that", "phosphorylation", "of", "HIV-TF1", "was", "essential", "for", "DNA", "binding", "." ]

[ 0, 0, 0, 0, 0, 9, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0 ]

[ "Both", "drugs", "dose-dependently", "inhibited", "LPS-induced", "TF", "and", "TNF-alpha", "synthesis", "at", "the", "mRNA", "and", "the", "protein", "level", ",", "and", "reduced", "PGE2", "production", "." ]

[ 0, 0, 0, 0, 9, 10, 0, 9, 0, 0, 0, 3, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0 ]

[ "Two", "of", "the", "genes", "defective", "in", "the", "five", "complementation", "groups", "identified", "in", "the", "class", "II-negative", "bare", "lymphocyte", "syndrome", "or", "corresponding", "laboratory", "mutants", "have", "been", "cloned", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "A", "transcriptional", "regulatory", "element", "is", "associated", "with", "a", "nuclease-hypersensitive", "site", "in", "the", "pol", "gene", "of", "human", "immunodeficiency", "virus", "type", "1", "." ]

[ 0, 1, 2, 2, 0, 0, 0, 0, 1, 2, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0 ]

[ "The", "effects", "of", "1", "alpha", ",", "25-dihydroxyvitamin", "D3", "(", "VD3", ")", "on", "proliferation", ",", "differentiation", ",", "and", "macromolecular", "synthesis", "in", "the", "new", "Philadelphia", "chromosome-positive", "chronic", "myelogenous", "leukemia", "cell", "line", ",", "RWLeu-4", ",", "were", "investigated", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 6, 6, 6, 6, 6, 0, 5, 0, 0, 0, 0 ]

[ "with", "culture", "doubling", "times", "of", "about", "25", "h", "for", "both", "serum-supplemented", "and", "serum-free", "cultures", "(", "viability", "greater", "than", "or", "equal", "to", "90", "%", ")", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 6, 6, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "The", "patients", "'", "plasma", "cortisol", "concentrations", "were", "normal", "or", "slightly", "elevated", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "These", "results", "advance", "the", "molecular", "understanding", "of", "opioid", "effects", "on", "lymphocytes", ",", "and", "in", "addition", ",", "demonstrate", "regulation", "of", "IL-2", "synthesis", "and", "secretion", "by", "the", "novel", "mechanism", "of", "receptor-mediated", "AP-1", "induction", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0 ]

[ "LPS", "treatment", "of", "RAW", "264.7", "cells", ",", "murine", "bone", "marrow-derived", "macrophages", ",", "and", "the", "human", "monocyte", "cell", "line", "THP-1", "resulted", "in", "rapid", "activation", "of", "the", "p46", "and", "p54", "isoforms", "of", "JNK", "." ]

[ 0, 0, 0, 5, 6, 6, 0, 7, 8, 8, 8, 0, 0, 0, 5, 6, 6, 6, 6, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 0, 9, 0 ]

[ "ZAP-70", "responsiveness", "to", "UV", "required", "expression", "of", "both", "CD3", "and", "CD45", ",", "whereas", "only", "CD3", "was", "required", "for", "the", "response", "to", "H2O2", "." ]

[ 9, 0, 0, 0, 0, 0, 0, 0, 9, 0, 9, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "In", "order", "to", "dissect", "the", "molecular", "mechanisms", "of", "monocytic", "differentiation", "we", "have", "developed", "a", "subtractive", "hybridisation", "method", "based", "on", "a", "simplified", "'representational", "difference", "analysis'", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "E2F-1", "blocks", "terminal", "differentiation", "and", "causes", "proliferation", "in", "transgenic", "megakaryocytes", "." ]

[ 9, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0 ]

[ "One", "ATF/CRE", "motif", "is", "located", "in", "the", "distal", "promoter", "at", "the", "nuclear", "matrix-associated", "Site", "IV", ",", "and", "the", "second", "motif", "is", "present", "in", "the", "proximal", "promoter", "at", "Site", "I", "." ]

[ 0, 1, 2, 0, 0, 0, 0, 1, 2, 0, 0, 1, 2, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 1, 2, 0 ]

[ "After", "20", "h", "of", "stimulation", "with", "8-bromo-cAMP", ",", "AR", "mRNA", "was", "upregulated", "in", "LNCaP", "but", "not", "in", "either", "PC-3", "or", "DU-145", "cell", "lines", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 0, 0, 0, 5, 0, 0, 0, 0, 5, 0, 5, 6, 6, 0 ]

[ "It", "is", "stated", "that", "GCR", "of", "healthy", "controls", "and", "GCS-untreated", "patients", "outnumbered", "those", "of", "cortisol-dependent", "BA", "patients", "on", "hormone", "therapy", "." ]

[ 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Here", "it", "is", "shown", "that", "the", "HIV-1", "viral", "particle", "contains", "multiple", "copies", "of", "the", "vpr", "protein", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0 ]

[ "In", "contrast", ",", "T", "cell", "activation", "induces", "a", "parallel", "decline", "in", "both", "site", "alpha-", "and", "beta-binding", "activities", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "In", "T", "cells", ",", "IL-13", "inhibits", "anti-CD3", "mAb/IL-2-", "or", "PHA-mediated", "IFN-gamma", "production", "and", "enhances", "cytolytic", "potential", "." ]

[ 0, 7, 8, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "The", "purpose", "of", "these", "studies", "was", "to", "identify", "whether", "transcription", "factors", ",", "associated", "with", "cytokine", "signalling", ",", "affected", "promoter", "activity", "of", "the", "corticotropin", "releasing", "hormone", "(", "CRH", ")", "gene", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 2, 2, 2, 2, 0 ]

[ "Epstein-Barr", "virus", "(", "EBV", ")", ",", "an", "oncogenic", "human", "herpesvirus", ",", "binds", "to", "and", "infects", "normal", "human", "B", "lymphocytes", "via", "CD21", ",", "the", "CR2", "complement", "receptor", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 8, 8, 0, 9, 0, 0, 9, 10, 10, 0 ]

[ "Jak3", "is", "associated", "with", "CD40", "and", "is", "critical", "for", "CD40", "induction", "of", "gene", "expression", "in", "B", "cells", "." ]

[ 9, 0, 0, 0, 9, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 7, 8, 0 ]

[ "The", "macrophage", "transcription", "factor", "PU.1", "directs", "tissue-specific", "expression", "of", "the", "macrophage", "colony-stimulating", "factor", "receptor", "." ]

[ 0, 9, 10, 10, 9, 0, 0, 0, 0, 0, 9, 10, 10, 10, 0 ]

[ "Since", "a", "common", "pathological", "finding", "in", "human", "T-cell", "leukemia", "virus", "type", "1", "(", "HTLV-1", ")", "-associated", "diseases", "is", "the", "infiltration", "of", "HTLV-1-infected", "T", "lymphocytes", "into", "various", "organs", ",", "we", "have", "looked", "for", "the", "profile", "of", "adhesion", "molecules", "expressed", "by", "HTLV-1-transformed", "T", "cells", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 7, 8, 8, 0 ]

[ "The", "ratio", "of", "BCL2+", "to", "CD3+", "cells", "in", "ectopic", "pregnancy", "was", "0.41", "." ]

[ 0, 0, 0, 7, 0, 7, 8, 0, 0, 0, 0, 0, 0 ]

[ "The", "Oct-1", "protein", "is", "present", "in", "all", "cell", "types", "analyzed", "so", "far", ",", "whereas", "Oct-2A", "and", "Oct-2B", "are", "found", "mainly", "in", "B", "lymphocytes", "." ]

[ 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 9, 0, 0, 0, 0, 7, 8, 0 ]

[ "In", "contrast", "to", "the", "MF", "individuals", "where", "no", "effect", "was", "seen", ",", "transendothelial", "migration", "of", "48-hr", "filarial", "antigen", "stimulated", "T-cells", "from", "LP", "individuals", "was", "significantly", "(", "P", "=", "0.01", ")", "greater", "than", "migration", "of", "48-hr", "media-stimulated", "T-cells", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 8, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0 ]

[ "Control", "of", "NFATx1", "nuclear", "translocation", "by", "a", "calcineurin-regulated", "inhibitory", "domain", "." ]

[ 0, 0, 9, 0, 0, 0, 0, 9, 10, 10, 0 ]

[ "The", "functional", "synergy", "between", "IL-12", "and", "IL-2", "involves", "p38", "mitogen-activated", "protein", "kinase", "and", "is", "associated", "with", "the", "augmentation", "of", "STAT", "serine", "phosphorylation", "." ]

[ 0, 0, 0, 0, 9, 0, 9, 0, 9, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Wild-type", "littermates", "remain", "unresponsive", "to", "TCF-1", "while", "they", "mount", "a", "high-titer", "antibody", "response", "to", "the", "fusion", "protein", ",", "Maltose", "Binding", "Protein", "(", "MBP", ")", "." ]

[ 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 9, 10, 10, 0, 9, 0, 0 ]

[ "We", "find", "that", "iNO", "produced", "by", "murine", "macrophage-like", "cells", ",", "RAW264.7", ",", "can", "inhibit", "cytokine", "-induced", "endothelial", "cell", "activation", "in", "a", "separated", "and", "mixed", "endothelial-RAW264.7", "coculture", "system", "." ]

[ 0, 0, 0, 0, 0, 0, 5, 6, 6, 0, 5, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 6, 0 ]

[ "Preliminary", "observations", "tend", "to", "correlate", "this", "CREF", "cell", "killing", "with", "the", "accumulation", "of", "the", "early", "viral", "proteins", "and/or", "viral", "DNA", "in", "the", "infected", "cells", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 1, 2, 0, 0, 7, 8, 0 ]

[ "Fluorescence", "in", "situ", "hybridization", "and", "analyses", "of", "a", "yeast", "artificial", "chromosome", "contig", "revealed", "that", "the", "human", "LOX-1", "gene", "is", "located", "in", "the", "natural", "killer", "gene", "complex", "on", "chromosome", "12p12-p13", ",", "where", "the", "genes", "of", "the", "natural", "killer", "cell", "receptors", "cluster", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0, 0, 0, 0, 9, 10, 10, 10, 0, 1, 2, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 0, 0 ]

[ "A", "second", "hypersensitive", "site", "(", "HS", "2", ")", "was", "identified", "within", "the", "first", "intron", "in", "pre-monocytic", "cells", ",", "which", "express", "Elk-1", "only", "when", "differentiating", "to", "monocytes", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 0 ]

[ "Thus", ",", "TAL1", "activation", "in", "these", "patients", "may", "result", "from", "subtle", "alterations", "in", "cis-acting", "regulatory", "sequences", "(", "affecting", "expression", "of", "a", "single", "TAL1", "allele", ")", "or", "changes", "in", "trans-acting", "factors", "that", "control", "TAL1", "transcription", "(", "affecting", "expression", "of", "both", "TAL1", "alleles", ")", "." ]

[ 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0, 0, 0, 0, 0, 1, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0 ]

[ "In", "addition", ",", "treatment", "of", "these", "nuclear", "extracts", "with", "sodium", "deoxycholate", "restored", "their", "ability", "to", "form", "the", "heterodimer", ",", "suggesting", "the", "presence", "of", "an", "inhibitor", "of", "NF-kappa", "B", "activity", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0 ]

[ "It", "is", "assumed", "that", "superaddition", "under", "such", "conditions", "of", "immune", "glomerulopathy", "(", "glomerulonephritis", "and", "nephrotic", "syndrome", ")", "gives", "rise", "to", "the", "resistance", "to", "the", "treatment", "with", "glucocorticoids", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "The", "human", "T-cell", "leukemia", "virus-encoded", "tax", "protein", "is", "a", "potent", "activator", "of", "many", "viral", "and", "cellular", "genes", "transcribed", "by", "RNA", "polymerase", "II", "." ]

[ 0, 9, 10, 10, 10, 10, 10, 0, 0, 0, 0, 0, 0, 1, 2, 2, 2, 0, 0, 9, 10, 10, 0 ]

[ "However", ",", "in", "vitro", "clonal", "growth", "assays", "performed", "on", "peripheral", "blood", "from", "transgenic", "versus", "control", "mice", "revealed", "a", "marked", "reduction", "of", "myeloid", "progenitors", ",", "especially", "in", "those", "responding", "to", "granulocyte/", "macrophage", "colony-stimulating", "factor", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 0 ]

[ "The", "effect", "of", "oestrogens", "on", "oestrogen-receptive", "organs", "and", "cells", "is", "mediated", "via", "intracellular", "receptors", "(", "ERalpha", "and", "ERbeta", ")", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 9, 0, 9, 0, 0 ]

[ "MATERIALS", "AND", "METHODS", ":", "Peptides", "derived", "from", "oncogenic", "proteins", "were", "screened", "for", "the", "presence", "of", "HLA", "binding", "motifs", ";", "actual", "binding", "were", "evaluated", "by", "HLA", "stabilization", "experiments", "using", "transfectants", "and", "specific", "anti-HLA", "antibodies", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0 ]

[ "The", "importance", "of", "many", "of", "these", "genes", "relates", "to", "the", "role", "their", "transcription", "factor", "products", "play", "in", "dictating", "patterns", "of", "expression", "of", "downstream", ",", "function-related", "genes", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0 ]

[ "Phosphorylation", "of", "TRAF2", "inhibits", "binding", "to", "the", "CD40", "cytoplasmic", "domain", "." ]

[ 0, 0, 9, 0, 0, 0, 0, 9, 10, 10, 0 ]

[ "In", "contrast", ",", "p65", "delta", ",", "a", "naturally", "occurring", "splice", "variant", ",", "fails", "to", "markedly", "augment", "I", "kappa", "B", "protein", "levels", "." ]

[ 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 0, 0 ]

[ "A", "novel", "heterodimerization", "partner", "for", "thyroid", "hormone", "receptor", "." ]

[ 0, 0, 9, 10, 0, 9, 10, 10, 0 ]

[ "Induction", "of", "fra-1", "following", "engagement", "of", "CD40", "did", "not", "require", "protein", "synthesis", ",", "suggesting", "that", "the", "PKC", "-dependent", "linkage", "between", "CD40", "and", "fra-1", "is", "direct", "." ]

[ 0, 0, 1, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 9, 0, 1, 0, 0, 0 ]

[ "Whereas", "different", "anti-CD4", "mAb", "or", "HIV-1", "gp120", "could", "all", "trigger", "activation", "of", "the", "protein", "tyrosine", "kinases", "p56lck", "and", "p59fyn", "and", "phosphorylation", "of", "the", "Shc", "adaptor", "protein", ",", "which", "mediates", "signals", "to", "Ras", ",", "they", "differed", "significantly", "in", "their", "ability", "to", "activate", "NF-AT", "." ]

[ 0, 0, 9, 10, 0, 9, 10, 0, 0, 0, 0, 0, 0, 9, 10, 10, 9, 0, 9, 0, 0, 0, 0, 9, 10, 10, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0 ]

[ "The", "immune", "response", "to", "Ad", "in", "BALB/c", "mice", "was", "more", "complex", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "After", "an", "additional", "6", "months", "(", "i.e.", "12", "months", "after", "surgery", ")", ",", "PHA", "-induced", "proliferation", "of", "PBMCs", "was", "similar", "in", "patients", "after", "adjuvant", "chemotherapy", "with", "CMF", "and", "in", "those", "receiving", "continued", "adjuvant", "tamoxifen", "treatment", "(", "P", ">", "0.1", ")", ",", "but", "in", "all", "patients", "still", "significantly", "decreased", "as", "compared", "with", "healthy", "controls", "(", "P", "<", "0.001", ")", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 7, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "In", "previous", "studies", ",", "it", "was", "shown", "that", "the", "fusion", "region", "of", "the", "pml/RAR-alpha", "protein", ",", "expressed", "by", "acute", "promyelocytic", "leukemia", "(", "APL", ")", "cells", ",", "can", "be", "specifically", "recognized", "in", "vitro", "by", "donor", "(", "D.", "E.", ")", "CD4", "T", "cells", "in", "a", "HLA", "class", "II", "DR11-restricted", "fashion", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 5, 6, 6, 6, 6, 6, 6, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 6, 0, 0, 9, 10, 10, 0, 0, 0 ]

[ "The", "effects", "mediated", "by", "a", "combined", "stimulation", "of", "cAMP", "-and", "protein", "kinase", "C", "(", "PKC", ")", "-dependent", "pathways", "have", "been", "investigated", "in", "different", "cellular", "systems", ",", "and", "it", "has", "been", "shown", "that", "they", "may", "complement", "each", "other", "in", "activating", "cell", "proliferation", "and", "differentiation", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "To", "determine", "whether", "it", "is", "possible", "to", "artificially", "enhance", "the", "opening", "of", "the", "chromatin", "structure", "of", "a", "minimal", "beta-globin", "promoter", ",", "we", "placed", "a", "101bp", ",", "erythroid-specific", "DNase", "1", "hypersensitive", "site-forming", "element", "(", "HSFE", ")", "immediately", "upstream", "of", "the", "beta-globin", "promoter", "and", "gene", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0, 0, 0, 0, 0, 0, 1, 2, 2, 2, 2, 2, 0, 1, 0, 0, 0, 0, 0, 1, 2, 2, 2, 0 ]

[ "The", "ZAP-70", "mutant", "studied", "here", "could", "be", "phosphorylated", "on", "tyrosine", "when", "associated", "to", "the", "TCR", "zeta", "chain", "and", "was", "able", "to", "bind", "p56", "(", "lck", ")", "." ]

[ 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 0, 0, 0, 0, 9, 10, 10, 10, 0 ]

[ "Thus", ",", "the", "protective", "role", "of", "BHRF1", "against", "apoptosis", "resembles", "that", "of", "Bcl-2", "in", "being", "cell", "type", "specific", "and", "dependent", "on", "the", "apoptotic", "stimulus", "." ]

[ 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]