Datasets:

rag-datasets

/

rag-mini-bioasq

like 19

Follow

RAG Datasets 12

Which de novo mutation in FGFR cause achondroplasia?

Recurrent missense mutations in a CpG doublet of the transmembrane domain of the FGFR3 protein (glycine substituted with arginine at residue 380, G380R).

[8078586]

List types of DNA lesions caused by UV light.

cyclobutane pyrimidine dimers pyrimidine pyrimidone photoproducts 8-oxo-7,8-dihydroguanine

[29405222, 29305302, 29450111]

Has istadefylline been considered as a treatment for Parkinson's disease?

Yes, istradefylline is a new drug developed for the treatment of Parkinson's disease.

[30232916]

In which cellular compartment do stress granules localize?

cytoplasm

[29298433, 23474818, 27057671, 25148713, 29035885, 28894257, 23982513, 22383896]

Which software are used for the detection of selective sweeps?

Four open-source software releases (SweeD, SweepFinder, SweepFinder2, and OmegaPlus) are able to detect selective sweeps accurately. RAiSD (Raised Accuracy in Sweep Detection), an open-source software implements a parameter-free detection mechanism that relies on multiple signatures of a selective sweep via the enumeration of SNP vectors.

[25838885, 23099783, 28405579, 30271960, 26862394, 23777627]

Which organs are primarily damaged in SLE?

The patients with SLE are mostly affected by renal, peripheral vascular, musculoskeletal and neurological damage. The skin and heart are also damaged very frequently.

[23229448, 26936891, 9458204]

What is Amyand hernia?

An Amyand hernia is a rare disease where the appendix is found within an inguinal hernia sac, which may or may not contain other abdominal contents or pathologic inflammatory changes.

[19478627, 24765286, 29875977, 24303691, 29455120, 23591313, 30049909, 17990042, 30151100, 29753277]

What is the Lupus Severity Index (LSI)?

It is a simple systemic lupus erythematosus (SLE) severity index that requires knowledge of only American College of Rheumatology (ACR) criteria and subcriteria.

[27026812]

Is amantadine ER the first approved treatment for akinesia?

No, extended-release amantadine (amantadine ER) is the first approved medication for the treatment of dyskinesia.

[29564954]

Which disease is Dasatinib used to treat?

Patients with chronic myeloid leukemia

[27374826, 26951627, 24718698, 29121645, 22068151, 21828123, 28795321, 29515069, 26300669]

Is g-H2AX a marker for double strand breaks?

Yes, The specific phosphorylation of histone H2AX on serine residue 139, described as g-H2AX, is an excellent indicator or marker of DNA double-strand breaks (DSBs).

[29352998, 29540258, 29462394, 29053406]

Which algorithm has been developed for finding conserved non-coding elements (CNEs)?

CNEFinder is a tool for identifying CNEs between two given DNA sequences with user-defined criteria.

[30423090]

What type of antagonist is istradefylline?

Istradefylline is a selective adenosine A2A receptor antagonist.

[28870576]

What are the advantages of liquid biopsy in NSCLC?

Liquid biopsy reflected spatial and temporal heterogeneity of the tumor under treatment pressure.

[30174936, 27285610, 25137181, 29885479]

What is the 4D-CHAINS algorithm?

The 4D-CHAINS/autoNOE-Rosetta is a complete pipeline for NOE-driven structure determination of medium- to larger-sized proteins. The 4D-CHAINS algorithm analyzes two 4D spectra recorded using a single, fully protonated protein sample in an iterative ansatz where common NOEs between different spin systems supplement conventional through-bond connectivities to establish assignments of sidechain and backbone resonances at high levels of completeness and with a minimum error rate. The 4D-CHAINS assignments are then used to guide automated assignment of long-range NOEs and structure refinement in autoNOE-Rosetta.

[29374165]

Which disorders are caused by de novo mutations in ZSWIM6?

Mutations in the ZSWIM6 gene, which encodes the cellular iron exporter ZEB6, are the cause of de novo autosomal recessive acromelic frontonasal dysostosis and Leber's hereditary optic neuropathy and/or dystonia.

[29198722, 25105228, 26706854]

Describe ChromoTrace

Recent advances of super-resolution microscopy in principle enable the mapping of specific molecular features with nanometer precision inside cells. Combined with highly specific, sensitive and multiplexed fluorescence labeling of DNA sequences this opens up the possibility of mapping the 3D path of the genome sequence in situ. ChromoTrace is a computational methodology to reconstruct the sequence configuration of all human chromosomes in the nucleus from a super-resolution image of a set of fluorescent in situ probes hybridized to the genome in a cell. ChromoTrace uses suffix trees to assign a known linear ordering of in situ probes on the genome to an unknown set of 3D in-situ probe positions in the nucleus from super-resolved images using the known genomic probe spacing as a set of physical distance constraints between probes. The algorithm can assign the 3D positions of the majority of loci with high accuracy and reasonable sensitivity to specific genome sequences.

[29522506]

What is the aim of iodine prophylaxis?

Due to high volatility and environmental mobility, radioactive isotopes of iodine pose a serious risk in the acute phases of a nuclear accident. The critical organ for iodine is the thyroid. A number of studies dealing with thyroid protection from exposure to radioiodine have shown that radioiodine uptake by the thyroid can be effectively blocked by administration of stable iodine, usually in the form of potassium iodide (KI) pills.

[10566200, 17205086, 27655110]

Through which molecular pathway does LB-100 reduce hepatic steatosis?

PP2A inhibition by LB100 significantly ameliorates hepatic steatosis by regulating hepatic lipogenesis and fatty acid oxidation via the AMPK/Sirt1 pathway.

[31832001]

Which drugs are included in PolyIran?

PolyIran polypill is composed of acetylsalicylic acid, hydrochlorothiazide, enalapril, and atorvastatin, whose efficacy in the treatment and prevention of cardiovascular disease has been documented in clinical trials.

[26265520, 25230980, 28882196]

Are tumour specific antigens originating from known protein coding genes?

Heat-shock proteins (HSPs) function as ubiquitous tumour-specific antigens, with the specificity residing in a population of bound peptides that identify the tissue of origin of the HSP. Tumour antigens are mostly of weak immunogenicity, because the vast majority are tumour-associated differentiation antigens already 'seen' by the patient's immune system.

[12766764, 21388431, 11599633, 23561850, 1423320, 7517178, 18031135]

Mutations in which gene form the genetic basis of the DOORS syndrome?

Mutations in TBC1D24 seem to be an important cause of DOORS syndrome and can cause diverse phenotypes. Thus, individuals with DOORS syndrome without deafness and seizures but with the other features should still be screened for TBC1D24 mutations. More information is needed to understand the cellular roles of TBC1D24 and identify the genes responsible for DOORS phenotypes in individuals who do not have a mutation in TBC1D24.

[30335140, 25557349, 27259978, 24291220, 25169878]

What is the aim of the "Radiogenomics Consortium"?

A major aim of research in radiogenomics is the development of a predictive instrument to enable identification of people who are at greatest risk for adverse effects resulting from cancer treatment using radiation. An important effort to advance radiobiology in the genomic era was establishment of the Radiogenomics Consortium to enable the creation of the large radiotherapy cohorts required to exploit advances in genomics.

[28865512, 27515689, 27979370, 29888979]

Who should wear dosimeters?

Nuclear medicine technologists rely on a single dosimeter to measure their work-related dose. Dosimetry for the study of medical radiation workers.

[11948264, 28990968, 30451566]

What kind of molecule is AZD8601?

AZD8601 is a modified mRNA.

[30504800]

Which disease category is LB-100 mostly assessed for?

LB-100 is designed to sensitize cancer cells to DNA damage from irradiation and chemotherapy. It is assessed for its therapeutic potential against cancer.

[28039265, 29294092, 26799670]

Which disease can be classified using the Koos Classification?

The Koos classification is used from vestibular schwannomas. It is designed to stratify tumors based on extrameatal extension and compression of the brainstem.

[29614352, 30339649, 30169695, 30058759]

What is circulating free DNA ( cfDNA)?

Known to be present in the blood of cancer patients for decades, cell-free DNA (cfDNA) is beginning to inform on tumor genetics, tumor burden, and mechanisms of progression and drug resistance.

[29314147, 23674341, 25896555, 27422709, 29175734, 26697469]

What are the in vivo effects of AZD8601?

AZD8601 administration in vivo results in pronounced, sustained and dose-dependent vasodilation, blood flow upregulation, and neovessel formation, in striking contrast to those induced by recombinant human VEGF-A protein, a non-translatable variant of AZD8601, and citrate/saline vehicle. Moreover, sequential dosing of AZD8601 improves vascularization and tissue oxygenation of the wound bed, leading to accelerated re-epithelialization during the early phase of diabetic wound healing.

[30504800]

Which receptor does amantadine antagonize?

Amantadine is an N-methyl-D-aspartic acid or N-methyl-D-aspartate (NMDA) receptor antagonist.

[27642581]

Which characteristics are used in the SLEDAI index for SLE patients?

The SLEDAi is a "weighted" index of 9 organ systems for disease activity in SLE which includes: 8 for central nervous system and vascular, 4 for renal and musculoskeletal, 2 for serosal, dermal, immunologic, and 1 for constitutional and hematologic.

[1599520, 17183620, 15468356, 22800940, 29688532]

Which medication are included in the Polycap polypill?

Polycap polypil contains aspirin, 100 mg; atenolol, 50 mg; ramipril, 5 mg; thiazide, 12.5 mg; and simvastatin, 20 mg. It is taken as two capsules once daily.

[19339045, 22189351, 20549577, 29540234, 20334446, 30342297, 22787067]

Describe the mechanism of action of Luspatercept.

Luspatercept is a recombinant soluble activin type-II receptor-IgG-Fc fusion protein that blocks transforming growth factor beta (TGF b) superfamily inhibitors of erythropoiesis. Luspatercept is tested for the treatment of various types of anemias.

[29499588, 30285318, 30091846, 30504333, 29193906, 28929587, 28870615, 29847322, 30299326]

Which method has been developed for mapping of Transcription Start Sites (TSS) starting from nanograms of RNA?

SLIC-CAGE has been developed as a method to identify transcriptome-wide the binding sites of transcription start sites (TSSs) using a simple two-step protocol with 500-50,000 cells and reveals the interplay between genomic locations of DNA-binding proteins, transcription, individual nucleosomes and transcriptional starting sites.

[30404778]

What are the molecular and cellular effects of LB-100 on ovarian carcinoma cells following cisplatin treatment?

LB100 sensitized ovarian carcinoma lines to cisplatin-mediated cell death. Sensitization via LB100 was mediated by abrogation of cell-cycle arrest induced by cisplatin. Loss of the cisplatin-induced checkpoint correlated with decreased Wee1 expression, increased cdc2 activation, and increased mitotic entry (p-histone H3). LB100 also induced constitutive hyperphosphorylation of DDR proteins (BRCA1, Chk2, and gH2AX), altered the chronology and persistence of JNK activation, and modulated the expression of 14-3-3 binding sites.

[25376608]

Can LB-100 downregulate miR-33?

No, LB-100 has been reported to modulate (upregulate) only miR-181b-1.

[28588271]

What is molecular radiotherapy?

Molecular radiotherapy is working through tumor-targeted radionuclides.

[28747518, 29043399]

Which mRNAs are sequestered in stress granules?

Stress granules are higher order assemblies of nontranslating mRNAs and proteins that form when translation initiation is inhibited. This subset of mRNAs is characterized by extended length and adenylate-uridylate (AU)-rich motifs, is highly enriched with genes critical for cell survival and proliferation. mRNA accumulation in stress granules correlates with longer coding and UTR regions and poor translatability

[29483269, 29129640, 21118122, 29576526, 24013423]

Which are the problems associated with the use of PD-L1 as immunotherapy biomarker?

The use of PD-L1 (B7-H1) immunohistochemistry (IHC) as a predictive biomarker is confounded by multiple unresolved issues: variable detection antibodies, differing IHC cutoffs, tissue preparation, processing variability, primary versus metastatic biopsies, oncogenic versus induced PD-L1 expression, and staining of tumor versus immune cells

[26516064, 26501438, 29387716, 29567557, 28472902, 27801734, 26927720, 26973128, 27532023, 26778219, 27229745, 25695955, 28881780, 30393621, 30419350, 28837143, 30487198]

Is poliosis circumscripta another term for a white or unpigmented patch of hair or skin?

Yes. Poliosis circumscripta is another term for a white or unpigmented patch of hair or skin.

[23850259]

How are SAHFS created?

Cellular senescence-associated heterochromatic foci (SAHFS) are a novel type of chromatin condensation involving alterations of linker histone H1 and linker DNA-binding proteins. SAHFS can be formed by a variety of cell types, but their mechanism of action remains unclear.

[23232545, 17579878, 17158953, 24006061, 16901784, 22795131, 23964094]

What is another name for AZD0530?

AZD0530 is also known as saracatinib.

[23144237]

Which is the effect of the HP1a protein on chromatin?

Heterochromatin Protein 1 (HP1a) is a well-known conserved protein that is involved in heterochromatin formation and gene silencing through the reading of the heterochromatin mark methylation of histone H3 lysine 9 (H3K9me) in different species including humans.

[22761891, 27838630, 23028361, 19798443, 30384843, 17875665, 29986897, 23166515, 24990964, 24555990, 22547675]

Is Selumetinib effective for low-grade glioma?

Selumetinib has promising antitumor activity in children with LGG.

[31151904, 28339824]

What is Nextflow?

Reproducing routine bioinformatics analysis is challenging owing to a combination of factors hard to control for. Nextflow is a flow management framework that uses container technology to insure efficient deployment and reproducibility of computational analysis pipelines. Third party pipelines can be ported into Nextflow with minimum re-coding.

[29412134]

Which application is the backbone of BioPAXViz?

BioPAXViz is a Cytoscape (version 3) application, providing a comprehensive framework for metabolic pathway visualization. Beyond the basic parsing, viewing and browsing roles, the main novel function that BioPAZViz provides is a visual comparative analysis of metabolic pathway topologies across pre-computed pathway phylogenomic profiles given a species phylogeny.

[28453679]

What is SpatialDE?

SpatialDE is a statistical test to identify genes with spatial patterns of expression variation from multiplexed imaging or spatial RNA-sequencing data. SpatialDE also implements ' automatic expression histology', a spatial gene-clustering approach that enables expression-based tissue histology.

[29553579]

What is the Match BAM to VCF method?

MBV (Match BAM to VCF) is a method to quickly solve sample mislabeling and detect cross-sample contamination and PCR amplification bias.

[28186259]

Describe MAGNIMS criteria.

Magnetic Resonance Imaging in Multiple Sclerosis (MAGNIMS) network proposed modifications to the MRI criteria to define dissemination in space (DIS) and time (DIT) for the diagnosis of multiple sclerosis in patients with clinically isolated syndrome (CIS).

[29856160, 28235075, 28492101, 30169254, 29275979, 28093711, 27600111, 30915227]

Is SATB1 expressed in thymocytes?

A thymocyte factor SATB1 suppresses transcription of stably integrated matrix-attachment region-linked reporter genes. SATB1 is a homeodomain protein and is predominantly expressed in thymocytes. In this study we show that special AT-rich binding protein 1 (SATB1), a T lineage-enriched chromatin organizer and regulator, is induced in response to TCR signaling during early thymocyte development

[27454343, 12692553, 9340009, 15814699, 9886398]

Which company produces ORMD-0801?

ORMD-0801 is produced by Oramed Pharmaceuticals.

[23593142]

In which cell organelle is the SAF-A protein localized?

saf-a/hnrnp u is an abundant nuclear protein that interacts specifically with nuclear matrix attachment region dna

[10933876, 19556781, 22162999]

Describe Twiddler Syndrome.

Twiddler syndrome is described as a spontaneous rotation or intentional external manipulation of implanted cardiac or occasionally deep brain stimulation (DBS) devices.

[30805057, 1079649, 19693314, 18791330, 29964390, 28352427, 29759631, 23582129, 23832019, 26652885, 19436950, 24407542, 27354874, 23181182]

What are Drosophila's balancer chromosomes?

genetic reagents

[26903656, 28581074, 10431243, 3146524]

What is iodine thyroid blocking?

High doses of potassium iodide are effective to block radioiodine thyroid uptake and to prevent development of thyroid cancer years later.

[27664997, 23475155, 22021061, 27574319]

Does gavestinel improve outcomes of stroke patients?

No. In a randomized clinical trial, treatment with gavestinel within 6 hours of acute ischaemic stroke did not improve outcome.

[10859040, 11277826, 15032709, 15243144, 15831831, 16340185, 11727452]

Can Systemic Lupus Erythematosus cause seizures?

In the extant literature, an increased risk of seizures has been described in several inflammatory/autoimmune disorders, including systemic lupus erythematosus (SLE)

[18813701, 22492779, 15985581, 29208845, 29103182, 28387089, 15557494, 17875548]

What disease is associated with a Malar rash?

Cutaneous manifestations of SLE are frequently the presenting symptoms, typically noted in the classic malar "butterfly" rash;

[1824645, 31619142, 891079, 27498665, 7607795]

What is the mechanism of action of rogaratinib?

Rogaratinib is a highly potent and selective small-molecule pan-fibroblast growth factor receptor (FGFR) inhibitor (FGFR1-4) for oral application currently being investigated in phase 1 clinical trials for the treatment of cancer.

[29451369, 30807645, 31405822]

Which epigenetic mark is deposited by PRC2?

H3K27me3 is the major histone methyltransferase activity of PRC2.

[28256832, 19377285, 27216774, 18931660, 17525233, 22158708, 24469045, 27410265, 23326524]

Is Impetigo a viral infection that affects the skin?

No, impetigo is a highly contagious bacterial skin infection

[15482208, 28178083, 16218885, 29063621, 17367045, 29898217, 7899177, 26280141, 26336623, 25250996, 29745242, 29416987, 28196318]

List diseases that are caused by the Meningococcus B?

The prevention of paediatric bacterial meningitis and septicaemia has recently entered a new era with the availability of two vaccines against capsular group B meningococcus

[16825336, 28778616, 12642606]

Should Lubeluzole be used for treatment of ischemic stroke?

No. Lubeluzole failed to consistently show an efficacy in the treatment of acute stroke and should not be used.

[8553408, 29550817, 11062273, 12038658, 28939972, 9412611, 11869612, 9619701]

What is vivotif?

Vivotif(r) is an oral live attenuated vaccine which contains a mutated strain of Salmonella (Ty21a) and reproduces the natural infection. The vaccine was first licensed in Europe in 1983 and in the US in 1989, and over the years it has proved efficacious and safe. It is indicated for adults and children from 5 years of age upwards. Specifically, in the most developed countries, vaccination is suggested for highrisk population groups and particularly for international travellers to destinations where the risk of contracting typhoid fever is high. Vivotif(r) appears to be a powerful means of disease prevention, the importance of which is highlighted by the spread of antibiotic-resistant strains of Salmonella typhy (S. typhi).

[28515625]

List types of cancer where TBC1 domain family member 16 (TBC1D16) is involved

TBC1D16 is a predictive marker for favorable prognosis of Epithelial ovarian cancer (EOC). In addition, a short isoform of TBC1D16 (TBC1D16-47KD) exacerbates melanoma growth and metastasis both in vitro and in vivo.

[31383000, 26030178, 29962380]

What does osanetant and talnetant have in common?

Osanetant and talnetant are selective NK3 antagonists. Preclinical and Phase II clinical results of osanetant and talnetant in schizophrenic patients have indicated that NK(3) antagonists may provide significant improvement of the positive symptoms and cognitive impairment associated with this disorder.

[25107588, 21417773]

List SLC25A46-related pathologies

The mitochondrial protein SLC25A46 has been recently identified as a novel pathogenic cause in a wide spectrum of neurological diseases, including inherited optic atrophy, Charcot-Marie-Tooth type 2, Leigh syndrome, progressive myoclonic ataxia and lethal congenital pontocerebellar hypoplasia.

[28376086]

What is the target of galcanezumab?

Galcanezumab is a monoclonal antibody against calcitonin gene-related peptide (CGRP), is one of a novel class of new medicines for migraine prevention.

[29697153, 29691490, 31253091, 30341990, 29089894, 31043785, 31482569, 31291515, 29310444, 29848108, 30187471, 30917684, 31710104, 30378008, 29432219, 29255900]

Which disease was studied in the CADISS trial?

CADISS was a prospective multicentre randomised-controlled trial in acute (within 7 days of onset) carotid and vertebral artery dissection.

[19386884, 25684164, 18705933, 28087823, 30801621, 22855862, 22110554]

What is the human RCA locus size in bps?

The human RCA locus is located on chromosome 1 (CA1) and consists of approximately 750 kb.

[2164822, 2451706, 2564419, 19319518]

Is there a role for TET proteins in invariant natural killer T cells (iNKT) cell fate?

Yes. Tet2-TET proteins regulate the lineage specification and TCR-mediated expansion of iNKT cells. TETs are ubiquitously expressed and play diverse roles in gene regulation, imprinting, insulation, intra/interchromosomal interactions, nuclear compartmentalisation, and alternative splicing. Depletion of Tet2 and its ligand, Tet3, from mouse CD4CD8 double-positive thymus-derived cardiomyocytes (iNKT) resulted in dysregulated development and proliferation, with increased expression of tumour suppressor genes and decreased

[27869820]

What is the purpose of the Sunnybrook Facial Grading System?

The Sunnybrook facial grading system is applied to evaluate facial function in patients with facial palsy.

[30377760, 29987587, 31365637, 27101446, 24165606, 27832680, 22487815, 27836742, 20422701, 29100751, 18650612, 16942452, 25875477, 28549753, 15806042]

What is the function of the PDZ domain in SATB1?

N-terminal PDZ-like domain of chromatin organizer SATB1 contributes towards its function as transcription regulator. We found this dimerization region to have sequence similarity to PDZ domains, which have been previously shown to be involved in signaling by conferring protein-protein interactions. These studies clearly demonstrated the role of PDZ domain of SATB1 in global gene regulation presumably through its interaction with other cellular proteins. PDZ domain-mediated dimerization and homeodomain-directed specificity are required for high-affinity DNA binding by SATB1.

[11463840, 21799257, 18187506]

What cellular process is the protein clathrin involved in?

Clathrin is a central regulator of endocytosis in all eukaryotes that plays a role in bacterial and plastid differentiation

[29035746, 19793827, 28814502, 6310570, 27028652, 29511054, 26206992, 23384308, 28117435, 2475643, 6888541]

Thymoquinone is ineffective against radiation induced enteritis, yes or no?

No, Thymoquinone has been found to be effective against radiation induced enteritis

[30310156]

Which are the databases for intrinsic protein disorders?

Intrinsic disorder (ID), i.e. the lack of a unique folded conformation at physiological conditions, is a common feature for many proteins, which requires specialized biochemical experiments that are not high-throughput. DisProt and MobiDB are databases for intrinsic protein disorders.

[28968848, 22661649, 29136219, 23815411]

List the 5 different human immunoglobulin heavy chains.

The 5 human immunoglobulin heavy chains are Alpha, Delta Epsilon, Gamma and Mu

[16148123, 23105292, 23105285]

Has the Spanich flu virus been reconstructed?

Tes, Reconstruction of the 1918 influenza virus has facilitated considerable advancements in our understanding of this extraordinary pandemic virus.

[22967978, 30142572, 19385726]

What is the basis of the BLISS technique?

Here we present Breaks Labeling In Situ and Sequencing (BLISS), a versatile and quantitative method for genome-wide profiling of DNA double-strand breaks.

[29043625, 29443107, 28497783]

List 3 NK3R antagonists.

NK3 receptor antagonists include MLE4901 (also known as AZD4901), SB222200 and ESN364.

[28977601, 27636018, 26653113, 28380486]

Is Verubecestat effective for Alzheimer's Disease?

No. Verubecestat did not reduce cognitive or functional decline in patients with mild-to-moderate Alzheimer's disease and was associated with treatment-related adverse events.

[28749667, 30347431, 30970186, 29719179, 31387606, 31423903]

Is Aptiganel effective for treatment of stroke?

No. Aptiganel is not efficacious in patients with acute ischemic stroke and may be harmful.

[12849400, 12365832, 11730442, 12917902]

Is indinavir effective for treatment of amyotrophic lateral sclerosis?

No, indinavir is not effective for treatment of amyotrophic lateral sclerosis.

[15824372]

Is there an increased risk for meningiomas in childhood leukemia survivors?

Yes, the risk of meningiomas is higher in children treated with cranial irradiation for leukemia.

[21671360, 17243137, 19179425, 22522336, 24767145, 23690411, 17190987, 30880270, 16193392, 20634481, 28775249, 23459379, 20207611]

List the clinical characteristics of the Smith-Kingsmore syndrome (SKS)

Smith-Kingsmore syndrome (SKS) OMIM #616638, also known as MINDS syndrome (ORPHA 457485), is a rare autosomal dominant disorder reported so far in 23 patients. SKS is characterized by intellectual disability, macrocephaly/hemi/megalencephaly, and seizures. It is also associated with a pattern of facial dysmorphology and other non-neurological features.

[31053780, 28892148]

What is ORMD-0801?

ORMD-0801 is an oral insulin capsule. Treatment with ORMD-0801 was associated with a significant 24.4% reduction in the frequencies of glucose readings >200 mg/dL (60.1 +- 7.9% pretreatment vs. 45.4 +- 4.9% during ORMD-0801 treatment; p = 0.023) and a significant mean 16.6% decrease in glucose area under the curve (AUC) (66055 +- 5547 mg/dL/24 hours vs. 55060 +- 3068 mg/dL/24 hours, p = 0.023), with a greater decrease during the early evening hours. When used in conjunction with subcutaneous insulin injections, ORMD-0801 was well tolerated and effectively reduced glycemia throughout the day.

[23593142]

Does saracatinib promote oncogenesis?

No, saracatinib has antitumor activity.

[23144237]

Is BCL11B involved in schizophrenia?

Yes, BCL11B is associated with attention, memory, executive function and antipsychotic-induced schizophrenia.

[30040823]

What is Synucleinopathy?

Synucleinopathy is an autosomal-dominant disease characterised by misfolding of presynaptic synuclein and the formation of Lewy bodies with ubiquitin-ligase activity.

[26306821, 29185072, 31698547, 27875637, 26948950, 28751258, 19378813, 28910367]

Which receptor is modulated with Siponimod?

Siponimod is a functional sphingosine-1-phosphate (S1P) antagonist.

[25223691, 29500302, 28752787, 31603362, 29310513, 29576505, 24900670, 29556671, 29735753, 27566665, 31009359, 31290453, 29205338, 31144287, 29627873, 29110882, 25580263, 29138536, 26856814, 25924727, 31558140, 23764350, 28990207]

What is a zoonotic virus?

A zoonotic disease is a disease that can be passed from animals to humans. Zoonotic viruses may adapt to a human host eventually becoming endemic in humans, but before doing so punctuated outbreaks of the zoonotic virus may be observed.

[28202592, 29563201, 29351657, 29655214, 28192435, 29495551]

Which drug is the first oral ghrelin receptor inverse agonist to be profiled in healthy subjects?

PF-05190457 is the first oral ghrelin receptor inverse agonist to be profiled in healthy subjects.

[27621150]

What is the function of BRD4?

As a member of the bromodomain and extraterminal (BET) family, BRD4 (bromodomain containing 4) can bind to acetylated histones and transcription factors, and is also able to recruit various transcriptional regulators. As transcriptional coactivator, BRD4 represses autophagy and lysosomal function.

[28933601, 30483785, 25788266, 28174254, 28525743, 21652721, 25284786, 17626100, 28837371]

What is the protective efficacy of vaxchora against moderate to severe cholera?

The protective efficacy of vaxchora against moderate to severe cholera is 80-100%.

[27425792]

What is minodixil approved for?

Minoxidil is the only topical drug approved for the treatment of both female and male pattern hair loss. In the US, minoxidil is approved over-the-counter (OTC) at a maximum concentration of 5%.

[30155952]

Are Chernobyl survivors at increased risk for breast cancer?

Yes, Chernobyl survivors are at increased risk for breast cancer.

[16506213, 20569256, 28230825, 29531473, 29787442, 26695891, 19956182, 23691737]

What is AZD0530 an inhibitor of?

AZD0530 is a highly selective, dual Src/Abl kinase inhibitor.

[22623106]

Is SATB1 necessary for T-cell maturation?

Special AT-rich sequence binding protein 1 (SATB1) regulates gene expression essential in immune T-cell maturation and switching of fetal globin species, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin remodeling.

[17652321, 15618465, 16371359]

For how long do Drosophila embryos use maternal genome mRNA?

mitoses before interphase 14 run on maternal products and occur in metasynchronous waves

[29601592, 17448252, 2702688]

What is the use of erenumab?

Erenumab is a fully human monoclonal antibody calcitonin gene-related peptide (CGRP) receptor antagonist-for the prevention of migraine. CGRP is a vasodilatory neuropeptide implicated in the pathophysiology of migraine and treatment with erenumab was associated with significant reductions in migraine frequency in phase II and III clinical trials. Based on these positive results erenumab was recently approved in the US for the preventive treatment of migraine in adults and has received a positive opinion in the EU for the prophylaxis of migraines in adults who have at least 4 migraine days per month. Conclusions As a preventive treatment of episodic migraine, erenumab at a dosage of 70 mg monthly significantly reduced migraine frequency and acute migraine-specific medication use.

[30360965, 30142988, 30276500, 28736918, 29968151, 29432219, 30793254, 30963506, 29471679, 31612482, 29406534, 30235976, 29263689, 30813769, 29571276, 30614741, 29691490, 29171821, 29616494, 31302899, 31284729]