Datasets:

rag-datasets

/

rag-mini-bioasq

like 19

Follow

RAG Datasets 12

How is Slc22a3 imprinted?

Two novel imprinted genes, Slc22a2 and Slc22a3 are described here that lie 110 and 155 kb 3' to Igf2r and that are not overlapped by the Air transcript but are regulated by the Igf2r-ICE, as previously shown for Igf2r. A bidirectional silencer for a 400-kilobase region that contains three imprinted, maternally expressed protein-coding genes (Igf2r/Slc22a2/Slc22a3) has been shown by targeted deletion to be located in a sequence of 3.7 kilobases, which also contains the promoter for the imprinted, paternally expressed non-coding Air RNA. Silencing of the paternal allele of three imprinted genes (Igf2r, Slc22a2 and Slc22a3) requires cis expression of the Air RNA

[18988810, 11562346, 12853484, 30268152, 25918552, 11845212, 16204191]

What are the effects of 14-3-3 dimers on Tau phosphorylation?

14-3-3 dimers regulate steady-state phosphorylation of both wild-type and the R406W mutant Tau, but they are not essential for toxicity of either variant. Furthermore, recruitment of dimers on accumulating wild- type Tau increases its steady- state levels ostensibly by occluding access to proteases in a phosphorylated-dependent manner.

[29659825]

Is the tyrosine kinase BTK implicated in autoimmunity?

Autoimmunity, hypersensitivity to B cell receptor (BCR) cross-linking, and splenomegaly caused by myeloerythroid hyperplasia were alleviated by Btk deficiency in lyn-/- mice. Augmented TLR9-induced Btk activation in PIR-B-deficient B-1 cells provokes excessive autoantibody production and autoimmunity. Autoimmunity was fully dependent on Btk kinase activity, because Btk inhibitor treatment (PCI-32765) could normalize B-cell activation and differentiation, and because autoantibodies were absent in Btk transgenic mice overexpressing a kinase inactive Btk mutant.

[27669440, 23672610, 9730885, 23136880, 22383797, 26341110, 26209625, 19687229]

What is the BioPlex network?

Protein interactions form a network whose structure drives cellular function and whose organization informs biological inquiry. BioPlex contains 23,744 interactions among 7,668 proteins with 86% previously undocumented. BioPlex accurately depicts known complexes, attaining 80%-100% coverage for most CORUM complexes. The network readily subdivides into communities that correspond to complexes or clusters of functionally related proteins. More generally, network architecture reflects cellular localization, biological process, and molecular function, enabling functional characterization of thousands of proteins. Network structure also reveals associations among thousands of protein domains, suggesting a basis for examining structurally related proteins. BioPlex, in combination with other approaches, can be used to reveal interactions of biological or clinical significance. For example, mutations in the membrane protein VAPB implicated in familial amyotrophic lateral sclerosis perturb a defined community of interactors.

[29054129, 26186194, 27552850]

Which algorithm has been developed for detecting expansions of tandem repeats?

Identifying large expansions of short tandem repeats (STRs), such as those that cause amyotrophic lateral sclerosis (ALS) and fragile X syndrome, is challenging for short-read whole-genome sequencing (WGS) data. A solution to this problem is an important step toward integrating WGS into precision medicine. For that purpose, ExpansionHunter has been developed as a software tool that, using PCR-free WGS short- read data, can genotype repeats at the locus of interest, even if the expanded repeat is larger than the read length.

[28887402]

Which clotting factor is in the Andexxa?

Andexxa(r) is a first-in-class recombinant modified factor Xa protein. It is available to reverse life-threatening or uncontrolled bleeding with the factor Xa inhibitors apixaban and rivaroxaban.

[29926311, 30053385, 30013295, 30459509, 30362966]

How are nucleosome posisitions correlated with sites of 5'-methyl-cytosine (5mC) or 5-hydroxy-methyl-cytosine (5hmC)?

We find that Mbd3 and Brg1 antagonistically regulate a common set of genes by regulating promoter nucleosome occupancy. outside of CpG islands most CpGs are methylated, and the average methylation density oscillates so that it is highest in the linker region between nucleosomes we have investigated nucleosome organization around hypomethylated regions (HMRs)

[26832418, 24812327, 22196727, 25263161, 25506399]

Which drugs are included in the drug LONSURF?

Lonsurf includes trifluridine and tipiracil. It is a novel oral anti-tumor agent combining an anti-neoplastic thymidine-based nucleoside analogue (trifluridine) with a thymidine phosphorylase inhibitor (tipiracil hydrochloride) presents a new treatment option for metastatic colorectal cancer patients refractory or intolerant to standard therapies.

[30350179, 27568360, 28977993, 27431756, 26197742, 29177842, 31489588, 26609205, 28213365, 28315543, 31002008, 30445951]

What is 23andMe?

We first take a look at how personal genomics services, exemplified by the company 23andMe,

[20415555, 27449572, 22616356, 29998537, 29469551, 18852208, 30452341, 28629370]

Is induction of interferon by TLR7 higher in males?

Yes. TLR7 activation correlates with induction of interferon more strongly in males.

[18088248]

Cushing's disease is associated with a tumor in what part of the body?

Cushing's disease is associated with a tumor in the pituitary gland

[15521676, 28413388, 31666445, 22918543, 30148086, 28850717]

Which was the first genetically modified organism (GMO) to be used as vaccine?

The first genetically modified organism to be used as vaccine was the live oral cholera vaccine CVD 103-HgR or vaxchora.

[27425792]

How does PRDM9 recognize the specific DNA motifs for meiotic recombination?

The PRDM9 gene encodes a protein with a highly variable tandem-repeat zinc finger (ZF) DNA-binding domain that plays a key role in determining sequence-specific hotspots of meiotic recombination genome wide. The long zinc finger domain of PRDM9 forms a highly stable and long-lived complex with its DNA recognition sequence.

[26351520, 22162947, 26840484, 28155083, 27932493, 22028627, 23651476, 29674518, 23618393, 29478809, 29072575]

Which micro-RNAs (miR) are associated with the human cycloxygenase-2 (COX-2) gene promoter?

MicroRNA-16, miRNA-128, miR-26b, icroRNA-26a, MicroRNA-146b-3p, microRNA-137, mi R-146a, mir-143-5p,microRNA-101, microRNAs-142-3 p, mi r-146p, mir-128 and miR -128 were found to be associated with the human cycloxygenase-2 (COX-2) gene promoter.

[29511456, 22049153, 29524580, 24616567, 25907560, 28678919, 27900011, 29404887, 28182010, 29945115, 24472607]

What percentage of patients of nasopharyngeal carcinoma (NPC) develop recurrent disease?

1.04% of patients with nasopharyngeal carcinoma develop recurrent disease. The overall recurrence rate is 75%.

[28849027, 21982471, 25607111, 25265358, 29290287, 28900497, 30142809]

What classes of drugs does Retapamulin belong to?

Retapamulin is a member of the pleuromutilin family of antibiotics.

[18389088, 18341664, 23793314, 19436611, 16940066, 17350985, 18041900, 22777229, 28533232, 28874907]

What is the mechanism of action of ozanimod?

Ozanimod is a specific and potent small molecule modulator of the sphingosine 1-phosphate receptor 1 (S1PR1) and receptor 5 (S1PR5), which has shown therapeutic benefit in clinical trials of relapsing multiple sclerosis and ulcerative colitis.

[28765121, 28783871, 27049060, 28398597, 30043658, 26990079, 31492652, 31492651, 29500302, 26239599, 27144850, 29125718, 30930775, 29608575]

What are Syndecans?

Syndecans are transmembrane proteoglycans with heparan and chondroitin sulfate chains attached to their extracellular domain. Like many proteoglycans, they interact with a large number of ligands, such as growth factors, adhesion receptors, soluble small molecules, proteinases, and other extracellular matrix proteins to initiate downstream signaling pathways. Syndecans play a major role in inflammation, mainly by regulating leukocyte extravasation and cytokine function.

[11900484, 29226950, 15936998, 29510059, 8875948, 26149933, 25572401, 16620374, 23384311, 29931674]

What is chemokinesis?

Chemokinesis is chemically prompted kinesis, a motile response of unicellular prokaryotic or eukaryotic organisms to chemicals that cause the cell to make some kind of change in their migratory/swimming behaviour.

[25290568, 8604012, 16317716, 29566102, 21743962, 15274332]

What cellular process is JAK/STAT involved in?

The Janus Kinase/Signal Transducers and Activators of Transcription (JAK/STAT) signaling pathway is utilized by numerous cytokines and interferons, and is essential for the development and function of both innate and adaptive immunity.

[26938566, 27713030, 26398764, 27928945, 28914550, 23827161, 28716890, 12479803, 22284190]

What is the link between dental x-ray and brain tumor risk?

There is data to suggest that dental x-ray can be associated with significantly increased risk of meningiomas and gliomas. However, some studies failed to demonstrate an association between dental x-rays and brain tumor risk.

[18447746, 2790826, 22492363, 23406732, 31502516, 1646072, 30661338, 26094363]

Is there a vaccine for rotavirus?

yes, rotavirus pentavalent vaccine (RotaTeq(r)) as a sole vaccine

[8920706, 27522178, 27443593, 22796685, 24422678, 26263200, 22119590, 8752295, 30046133, 19995190, 25680314, 22431803, 28442435, 19931717, 28369477, 9015114, 28340179, 31023829, 29102168, 7707626, 15502699, 22423021, 22702319, 11389295, 2851185, 20661105, 21504245, 16397431, 9949951]

Which T-UCR has been implicated in prostate cancer?

Transcribed ultraconserved region Uc.63+ promotes resistance to docetaxel through regulation of androgen receptor signaling in prostate cancer. Docetaxel is the standard chemotherapy for metastatic castration-resistant prostate cancer ( CRPC). However, nearly all patients ultimately become refractory due to the development of docetaxel resistance.

[29212226]

Is BNN20 involved in Parkinson's disease?

Yes. Neurotrophic factors are among the most promising treatments aiming at slowing or stopping and even reversing Parkinson's disease (PD). BNN-20 has been suggested as an important neuroprotective agent acting through the TrkB neurotrophin receptor pathway, mimicking the action of the endogenous neurotrophin BDNF. Thus BNN-20 could be proposed for treatment of PD.

[28461162]

Which domain of the MOZ/MYST3 protein complex associates with histone H3?

The double PHD finger domain of MOZ/MYST3 induces a-helical structure of the histone H3 tail

[19922872, 24150941]

Which company sells the drug Afrezza since 2015?

Afrezza has been marketed by Sanofi since February 2015.

[26222134]

Is there a role for MRPL53 in cancer?

No. MRPL53 is a new candidate gene for orofacial clefting identified using an eQTL approach.

[29053389]

Does Uc.63+ promote sensitivity to treatment in prostate cancer?

No. Overexpression of Uc.63+ increases the expression of AR and its downstream molecule PSA and promotes resistance to docetaxel through AR regulation. In patients treated with docetaxel, the expression of serum Uc.63+ in the docetaxel-resistant patients is higher than that in the docetaxel-sensitive patients (P = 0.011). Moreover, Kaplan-Meier analysis indicates that the high expression of serum Uc.63+ correlated with a worse prognosis (P = 0.020).

[29212226]

What is the gene PTENP?

PTEN pseudogene (PTENp) acts as an endogenous RNA, which regulates its parental gene by competitively binding to the 3' UTR of PTEN gene in the human.

[27936183]

Rachmilewitz Index is used for which diseases?

Rachmilewitz Index is used for assessment of endoscopic disease activity of patients with ulcerative colitis.

[26642816, 22994082, 7752802, 8649955, 24981894, 26894632, 25823689, 26985865, 15603341, 19821197, 17168120, 19462421, 30130840, 23511035, 30353757, 24742079]

List angiotensin-converting-enzyme inhibitors.

captopril enalapril lisinopril ramipril

[28475676, 27100959]

How does androgen deprivation therapy affect pain perception?

There were no significant changes in pain thresholds, ratings, or other response to quantitative sensory tests over the 6-month course of the study. Clinical pain did not differ between test and control groups, and no changes from baseline were observed in their group.

[28941963]

What is OAC CHV?

The Open Access and Collaborative Consumer Health Vocabulary (OAC CHV), which contains health-related terms used by lay consumers,

[28359728, 27884812]

What is known about autosomal dominant Alzheimer’s disease?

The first autosomal dominant mutation in the amyloid precursor protein (APP) gene was described in 1991. Later, AD was also associated with mutated early-onset (presenilin 1/2, PSEN1/2 and APP) and late-onset (apolipoprotein E, ApoE) genes. Genome-wide association and linkage analysis studies with identified multiple genomic areas have implications for the treatment of AD. The Dominantly Inherited Alzheimer Network, an international family-clustered registry to study autosomal dominant Alzheimer disease which is a rare form of Alzheimer disease caused by mutations in any of the three genes including the amyloid precursor protein, presenilin 1 and presenilin 2.

[28949931, 29182052]

List characteristic features of the Revesz syndrome.

Revesz syndrome is characterized by retinopathy, aplastic anemia, nail dystrophy, and cerebellar hypoplasia.

[27065378, 17874088, 17901676, 28095086, 25067791, 24321428, 17990901, 28866069, 29749240]

Does BNN27 promote memory loss?

No. The novel dehydroepiandrosterone (DHEA) derivative BNN27 counteracts delay-dependent and scopolamine-induced recognition memory deficits in rats.

[28274826]

Are genomic regulatory blocks (GRBs) any different than TADs?

No, clusters of CNEs (GRBs) strongly coincide with topological organisation, predicting the boundaries of hundreds of topologically associating domains (TADs) in human and Drosophila. The set of TADs that are associated with high levels of noncoding conservation exhibit distinct properties compared to TADs devoid of extreme noncoding conservation. The close correspondence between extreme noncoding conservation and TADs suggests that these TADs are ancient, revealing a regulatory architecture conserved over hundreds of millions of years.

[28874668]

Are Spinal Intradural Primary Malignant Peripheral Nerve Sheath Tumors(MPNST) rare in neurofibromatosis patients?

Spinal intradural primary malignant peripheral nerve sheath tumors (MPNST) are rare in patients without neurofibromatosis.

[24926928, 27593814]

What does MVA85A stand for?

MVA85A is the Modified Vaccinia virus Ankara expressing Antigen 85A.

[22789508]

Can MVA85A confer immunity against smallpox?

No MVA85A is a candidate tuberculosis vaccine.

[25726088]

Is MLL3 part of the ASCOM complex?

Yes

[21330447]

What are the effects of CAMK4 inhibition?

Here, we present evidence that the calcium/calmodulin-dependent protein kinase IV (CaMK4) is increased and required during Th17 cell differentiation. Inhibition of CaMK4 reduced Il17 transcription through decreased activation of the cAMP response element modulator a (CREM-a) and reduced activation of the AKT/mTOR pathway, which is known to enhance Th17 differentiation. CAMK4 knockdown and kinase-dead mutant inhibited crocin-mediated HO-1 expression, Nrf2 activation, and phosphorylation of Akt, indicating that HO-1 expression is mediated by CAMK4 and that Akt is a downstream mediator of CAMK4 in crocin signaling

[24667640, 30462889, 24839356]

List cohesinopathies

Roberts syndrome (RBS), Cornelia de Lange Syndrome (CdLS), Warsaw Breakage Syndrome (WABS) and Chronic Atrial and Intestinal Dysrhythmia (CAID) syndrome.

[25352100, 28422453]

Which protein is mutated in Erythropoietic Protoporphyria?

Erythropoietic protoporphyria (EPP) is a rare inherited disorder of the heme biosynthesis pathway resulting in the accumulation of protoporphyrins in the blood, erythrocytes, and other tissues. Because of a gene mutation in the FECH gene, ferrochelatase, the enzyme involved in the final step of heme synthesis, is deficient in these patients.

[29610169, 29116687, 30175727]

Is marimastat effective for small-cell lung cancer?

No. Marimastat is not effective for small-cell lung cancer.

[11894017, 12757409, 12431965]

Which part of the TNFR2 gene is genetically associated with Systemic Lupus Erythematosus?

There is a TNFR2 3' flanking region polymorphism in systemic lupus erythematosus.

[11607787, 11169260, 11196716, 11197692, 10395102]

What is VISMapper?

VISMapper is a vector integration site analysis web server to analyze next-generation sequencing data for retroviral vector integration sites. VISMapper can be found at: http://vismapper.babelomics.org.

[28931371]

What is Taupathy?

Tauopathies are a group of neurodegenerative disorders with accumulation of three-repeat (3R) or four-repeat (4R) Tau protein.

[23745112, 26611895]

Is Figitumumab effective for non-small cell lung cancer?

No. Phase III trials of the anti-insulin-like growth factor-1 receptor (IGF1R) antibody figitumumab in non-small cell lung cancer (NSCLC) patients have been discontinued owing to lack of survival benefit. Adding figitumumab to standard chemotherapy also failed to increase overall survival in patients with advanced nonadenocarcinoma NSCLC.

[23826179, 21907495, 28104361, 24888810, 20676809, 21717907, 21102589]

The LINCS L1000 data set contains gene expression data for drug treated human cells, yes or no?

The Library of Integrated Network-based Cellular Signatures (LINCS) L1000 dataset measures changes in GE before and after treatment of human cells with over 20 000 small-molecule compounds including most of the FDA-approved drugs.

[25609570, 27153606, 27796074, 29745839, 31258549, 28413689]

What is a cytokine storm?

A cytokine storm is an undesirable elevation of cytokine levels, as may occur in response to a drug or a device, may lead to severe side effects such as systemic inflammatory response syndrome.

[20736486, 29780651, 28951472, 29056305, 31039345, 23217619, 24728596, 24672024, 29039102]

Which database exists that contains regulatory SNPs which affect predicted transcription factor binding site affinity?

SNP2TFBS is a computational resource intended to support researchers investigating the molecular mechanisms underlying regulatory variation in the human genome. The database essentially consists of a collection of text files providing specific annotations for human single nucleotide polymorphisms (SNPs), namely whether they are predicted to abolish, create or change the affinity of one or several transcription factor (TF) binding sites. A SNP's effect on TF binding is estimated based on a position weight matrix (PWM) model for the binding specificity of the corresponding factor.

[27899579]

Which R package has been developed for MS-based label-free phosphoproteomics?

Phosphonormalizer is an R package for normalization of MS-based label-free phosphoproteomics.

[28968644]

Is there a vaccine for peanut allergy?

Yes, there is a vaccine for peanut allergy.

[25459578, 30319619, 26288733]

The virus that causes FIP, Feline Infectious Peritonitis belongs to what family?

The virus that causes FIP, Feline Infectious Peritonitis belongs to the family coronavirus.

[31375588, 22546085, 30065095, 27712624, 26656689, 29329682, 29778200, 23865689, 23763835, 25701212, 29478397]

What is a "cytokine storm"?

During infectious processes, the production of inflammatory cytokines including tumor necrosis factor (TNF), interleukin-1b (IL-1b), gamma interferon (IFNg) and chemokines orchestrates the anti-infectious innate immune response. However, an overzealous production, leading up to a cytokine storm, can be deleterious and contributes to mortality consecutive to sepsis or toxic shock syndrome.

[29056305, 29307884, 28918421, 29455535]

Is golimumab effective for sarcoidosis?

No, golimumab is not effective for treatment of sarcoidosis.

[25034562, 29601563]

Is SARS virus interacting with ACE2 encoded protein?

Yes, The infection of target cells by the SARS CoV is mediated through the interaction of the viral Spike (S) protein (1255 amino acids) and its cellular receptor, angiotensin-converting enzyme 2 (ACE2).

[30356097, 27082314, 29190287, 30102747, 26487711]

What is Soluvia?

Soluvia(tm) by Becton Dickinson is a microinjection system for intradermal delivery of vaccines.

[22149703]

Is the FIP virus thought to be a mutated strain for the Feline enteric Coronavirus?

yes, Feline infectious peritonitis (FIP) results from mutations in the viral genome during a common feline enteric coronavirus (FECV) infection.

[24707494, 24209771, 26822958, 19889934, 22280883, 27027316, 30691609, 23964891]

Does SATB1 regulate the RAG1 and RAG2 genes?

SATB1 binds to the ASE and Rag promoters, facilitating inclusion of Rag2 in the chromatin hub and the loading of RNA polymerase II to both the Rag1 and Rag2 promoters.

[25847946, 9886398]

What is the main difference between nascent and mature chromatin?

Nascent chromatin is created after transcription and is mostly lacking histone modifications and H1, which makes it more prone to digestion by DNaseI.

[6226660, 7171565, 1893943]

Is CTCF bound at nucleosome free regions?

yes, robust inter-nucleosomal interactions exist around transcription start site (TSS), transcription termination sites (TTS) or around CTCF binding sites

[25348714, 30414923, 30188887, 21249180, 16877759]

Is bortezomib a Proteasome inhibitor?

The proteasome inhibitor bortezomib is effective for a variety of tumors, but not for GBM. Proteasome inhibitor bortezomib

[22702336, 16278210, 26288836, 28409734, 28860152, 22027222, 22216088, 28317148, 21247388, 31088925]

Is PRDM9 essential for meiosis?

PRDM9 is essential for the progression through early meiotic prophase, including double strand break repair, homologous chromosome pairing, and sex body formation during spermatogenesis.

[30161134, 24634223, 23190393, 29674518, 19997497, 29478809]

What is particular about the mouse Fxy gene's chromosomal position?

We have previously described a gene, Fxy , that spans the pseudoautosomal boundary in mice such that the first three exons of the gene are located on the X chromosome, but the remainder of the gene is located on both X and Y chromosomes. The Fxy gene in mice is also located on the X chromosome but spans the pseudoautosomal boundary in this species.

[10508587, 10644436, 9425238]

Should Pentoxifylline be used for treatment of amyotrophic lateral sclerosis?

No. Pentoxifylline is not beneficial in amyotrophic lateral sclerosis and should be avoided in patients treated with riluzole.

[16401852]

What does a PET (Positron Excitation Tomography) measure?

Positron Excitation Tomography (PET) is a simple, reliable, and valid method of assessing brain activity in patients with Parkinson's disease (PD).

[28168704, 2101731, 18988199, 9439081, 23575833]

Is the CADM2 gene associated with differences in information processing speed?

Yes, genetic variation in the CADM2 gene is associated with individual differences in information processing speed.

[25869804, 28797215]

What is GeneCodeq?

The exponential reduction in cost of genome sequencing has resulted in a rapid growth of genomic data. Most of the entropy of short read data lies not in the sequence of read bases themselves but in their Quality Scores-the confidence measurement that each base has been sequenced correctly. Lossless compression methods are now close to their theoretical limits and hence there is a need for lossy methods that further reduce the complexity of these data without impacting downstream analyses. GeneCodeq is a Bayesian method inspired by coding theory for adjusting quality scores to improve the compressibility of quality scores without adversely impacting genotyping accuracy.

[27354700]

Is Nivolumab (Opdivo) a PD-L1 inhibitor?

No, Nivolumab (Opdivo) is a PD-1 inhibitor.

[27313464, 28833116, 30171077, 26514815]

Does clinical trial data support the use of minocycline for amyotrophic lateral sclerosis?

No. Available clinical trial data suggest that minocycline does not improve prognosis and functional status, and has a harmful effect on patients with amyotrophic lateral sclerosis.

[15159491, 16638021, 16193258, 18802797, 17980667]

What are apoptotic bodies?

Extracellular vesicles (EVs) are membrane-bound vesicles released into the extracellular space by almost all types of cells. EVs can cross the physiological barriers, and a variety of biological fluids are enriched in them. EVs are a heterogeneous population of vesicles, including exosomes, microvesicles, and apoptotic bodies. Apoptotic bodies are generated on apoptotic cell shrinkage and death.

[28684288, 29518372, 29181712, 29616307, 28766167]

Is the drug Exubera currently (March 2020) available?

No, Exubera has been discontinued due to suboptimal market acceptance.

[25485886]

What is the function of the ISW1 and CHD1 remodellers in yeast chromatin?

eviction of h1

[26861626, 22922743]

Are breaks in double stranded DNA associated with ionizing radiation?

Yes, double-strand breaks in double stranded DNA may be associated with ionizing radiation risk.

[6445538, 20079875, 1540967, 29956296, 29043625, 23948232, 29787435, 31652722, 10639091, 16650867, 26089209, 7683090, 9665145]

As of 2019, what type of cancer is commonly associated with ionizing radiation

Ionizing radiation is commonly associated with lung cancer, prostate cancer, breast cancer, cervical intraepithelial neoplasia and oral squamous cell carcinoma.

[26436129, 20921829, 19145669, 20518663, 25536554, 24597745, 7029300, 22077339]

Is KAT2A involved in Acute myeloid leukemia (AML)?

Yes. The KAT2A gene encodes a receptor tyrosine kinase that is frequently mutated in human acute myeloid leukemia (AML). Activating mutations in Kat2A in response to aberrations in TRAIL can lead to TRAIL-1 activation, resulting in the up-regulation of key AML genes, such as TGFb1, NF-kB, Akt, IKK-1, FOXO1, ERK1/2 and c-Myc.

[27760321]

What is Idiopathic toe walking?

Idiopathic toe walking is a pathological gait pattern in which children older than 3 years walk on their tip toes with no contact between the heels and the ground.

[17161602, 17260610, 28716514, 29881221, 28705637, 31587271, 29571089, 29664850, 18432151, 30347291, 29575996]

Is NicVAX vaccine effective for smoking cessation?

No. NicVAX vaccine failed to meet the primary endpoint in two large phase III studies, although the correlation of higher abstinence rates in subjects with higher immunity to nicotine was observed. The nicotine vaccine, NicVAX, does not appear to improve the chances of stopping smoking when given in addition to varenicline and behavioural support.

[23496672, 24894625, 21270788, 22895958, 22229310]

Does natalizumab improve disease course of secondary progressive multiple sclerosis?

No. Atalizumab treatment for secondary progressive multiple sclerosis did not reduce progression on the primary multicomponent disability endpoint in part 1, but it did reduce progression on its upper-limb component.

[26788129, 28861122, 29545067]

Before 2019, what neurologic diseases are associated with the tau protein?

Tau proteins are involved in the pathogenesis of multiple sclerosis and amyotrophic lateral sclerosis.

[22009441, 20826658, 29441009, 23552370, 27995573, 20678581, 27697018]

What is the difference between Daptacel and Pentacel?

Pentacel is a combination vaccine equivalent to the combination of Daptacel, IPOL and ActHIB vaccines.

[19117896]

AhR ligands are attractive drug targets for pharmaceutical development due to their induction of Cyp1a1, yes or no?

Yes, there is little evidence to support the indiscriminate exclusion of AhR activators/Cyp1a1 inducers from early drug developmental pipelines.

[17327465, 28944315]

Does the chromatin remodeling complex, RSC target H2A.Z nucleosomes?

H2A.Z probably helps RSC in keeping the gene nucleosome-free.

[18268003, 22122340, 19410542, 25813039, 21266479]

List radioprotection agents.

Amifostine CAPE Melanin Melatonin Metformin Tea polyphenols alpha-2-macroglobulin

[28581409, 30136132, 23796837, 25400428, 29671693, 27389300, 30360725, 29801788, 29141565]

What is the effect of Satb1 knock-out in mice?

inhibited cell viability and migration

[30024617, 15851481, 29388727]

Has ZP-PTH been tested in a phase II clinical trial?

Yes, ZP-PTH was successfully tested in a phase II clinical trial for the treatment of post-menopausal women with osteoporosis.

[20183917]

PH motifs in which genes endow breast cancer growth?

Although emerging roles of protease-activated receptor1&2 (PAR1&2) in cancer are recognized, their underlying signalling events are poorly understood. Signal-binding motifs in PAR1&2 are critical for breast cancer growth. This occurs via the association of the pleckstrin homology (PH) domain with Akt/PKB as a key signalling event of PARs. Other PH-domain signal-proteins such as Etk/Bmx and Vav3 also associate with PAR1 and PAR2 through their PH domains. PAR1 and PAR2 bind with priority to Etk/Bmx. A point mutation in PAR2, H349A, but not in R352A, abrogates PH-protein association and is sufficient to markedly reduce PAR2-instigated breast tumour growth in vivo and placental extravillous trophoblast (EVT) invasion in vitro. Similarly, the PAR1 mutant hPar1-7A, which is unable to bind the PH domain, reduces mammary tumours and EVT invasion, endowing these motifs with physiological significance and underscoring the importance of these previously unknown PAR1 and PAR2 PH-domain-binding motifs in both pathological and physiological invasion processes.

[26600192, 26928551]

What is herd immunity?

Vaccines are very effective in providing individual and community (herd) immunity against a range of diseases. We argue that individuals who have access to vaccines and for whom vaccination is not medically contraindicated have a moral obligation to contribute to the realisation of herd immunity by being vaccinated.

[28557577, 29047019, 29254557, 29429063]

Are multipotent adult progenitor cells effective for treatment of stroke?

No. There was no difference between the multipotent adult progenitor cell group and placebo groups in global stroke recovery at day 90. Further clinical trials evaluating the efficacy of the intervention in an earlier time window after stroke (<36 h) are planned.

[28320635]

List the stages/types of Multiple Sclerosis.

Multiple sclerosis presents with different phenotypes, most commonly a relapsing-remitting course and, less frequently, a progressive accumulation of disability from disease onset (primary progressive multiple sclerosis). The majority of people with relapsing-remitting multiple sclerosis, after a variable time, switch to a stage characterised by gradual neurological worsening known as secondary progressive multiple sclerosis.

[28349074, 29465579, 29968175]

What is known about Opicinumab for multiple sclerosis?

Opicinumab is a new Anti lingo 1 monoclonal antibody that is tested in relapsing remitting multiple sclerosis. The anti-LINGO-1 trial showed that the drug is safe and tolerable. A future phase II trial will provide more insights regarding the compound.

[28885860, 31285147, 29779852]

What is the target of Inebilizumab?

Inebilizumab is an anti-CD19 antibody with enhanced antibody-dependent cell-mediated cytotoxicity against B cells, is currently being evaluated in multiple sclerosis and neuromyelitis optica.

[29512131, 30915717, 31495497, 27886126, 29956883, 29447988, 28910968, 29143550]

Is eculizumab effective for Guillain-Barré syndrome?

In a clinical trial eculizumab did not achieve primary outcome for Guillain-Barre syndrome. However, because this was a small study without statistical comparison with the placebo group, the efficacy and safety of eculizumab could be investigated in larger, randomised controlled trials.

[31171755, 27801990, 29685815]

List Mcl-1 inhibitors.

A-1210477 S63845

[30185825, 29580266, 30017199, 30139826, 30185782]

Autophagy is the process where a virus obtains nutrients from it's host, yes or no?

No, autophagy is important in cellular homeostasis for the cell survival mechanism and is involved apoptosis.

[24914338, 24779013, 30544615, 28889353, 29022289, 22475795, 28884441, 31803515]

What is the basis of the methidiumpropyl-EDTA sequencing (MPE-seq) method?

MPE-seq (methidiumpropyl-EDTA sequencing) is a new method for the genome-wide characterization of chromatin that involves the digestion of nuclei with MPE-Fe(II) followed by massively parallel sequencing of the whole genome. Like micrococcal nuclease (MNase), MNase preferentially cleaves the linker DNA between nucleosomes. However, there are differences in the cleavage of nuclear chromatin by MP e-seq relative to MNase. Moreover, unlike MNase, MPe-seq cleaves nuclear DNA

[26080409]

Name two rotavirus vaccines.

Two rotavirus vaccines licensed for global use are RotaTeq and Rotarix.

[29436336]

Does CXorf21 escape X chromosome inactivation?

CXORF21 belongs to a set of X-linked differentially expressed genes that show verbal cognition-gene expression correlations may establish a causal link between these genes, neurodevelopment, and language function.

[24596594, 17504899, 17347996, 27729837]