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embedding_all-mpnet-base-v2
sequence
embedding_multi-qa-mpnet-base-dot-v1
sequence
embedding_all-MiniLM-L12-v2
sequence
24989152
4results
The psychotherapy ( CBT-ip ) arm showed a @ % seizure reduction ( P = @ ) and significant improvement from baseline in secondary measures including depression , anxiety , quality of life , and global functioning ( P < @ ) .
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24989152
4results
The combined arm ( CBT-ip with sertraline ) showed @ % seizure reduction ( P = @ ) and significant improvements in some secondary measures , including global functioning ( P = @ ) .
10
1,501
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24989152
4results
The sertraline-only arm did not show a reduction in seizures ( P = @ ) .
11
1,502
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24989152
4results
The treatment as usual group showed no significant seizure reduction or improvement in secondary outcome measures ( P = @ ) .
12
1,503
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24989152
1conclusions
This pilot randomized clinical trial for PNES revealed significant seizure reduction and improved comorbid symptoms and global functioning with CBT-ip for PNES without and with sertraline .
13
1,504
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24989152
1conclusions
There were no improvements in the sertraline-only or treatment-as-usual arms .
14
1,505
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24989152
1conclusions
This study supports the use of manualized psychotherapy for PNES and successful training of mental health clinicians in the treatment .
15
1,506
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24989152
1conclusions
Future studies could assess larger-scale intervention dissemination .
16
1,507
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25454967
3objective
This study compared the therapeutic effects of collateral meridian therapy ( CMT ) with traditional acupoint pressure therapy ( APT ) in patients with unilateral upper back pain .
0
1,508
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25454967
2methods
Forty-nine patients with active myofascial trigger points in upper trapezius muscle were randomly allocated to the control ( CTL ) , APT , or CMT group .
1
1,509
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25454967
2methods
Each subject in the CMT and APT groups received @ sessions of treatment per week over @ month .
2
1,510
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25454967
4results
Patients in the APT and CMT groups showed significant improvements @ month after treatment in visual analogue scale , range of motion , pain pressure threshold , regional superficial blood flow , and physical health , as compared to the CTL group .
3
1,511
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25454967
4results
No significant differences in outcome measures were found between APT and CMT groups @ month after treatment .
4
1,512
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25454967
1conclusions
Both APT and CMT have comparable therapeutic efficacy in the treatment of unilateral upper back pain with active myofascial trigger points in the upper trapezius muscle .
5
1,513
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25248648
0background
It remains unknown whether local anaesthetic dose is the only factor influencing continuous popliteal-sciatic nerve block effects , or whether concentration , volume , or both exert an influence as well .
0
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25248648
2methods
Bilateral sciatic catheters were inserted in volunteers ( n = @ ) .
1
1,515
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25248648
2methods
Catheters were randomly assigned to ropivacaine of either @ % ( @ ml h ( -@ ) ) or @ % ( @ ml h ( -@ ) ) for @ h.
2
1,516
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25248648
2methods
The primary endpoint was the tolerance to transcutaneous electrical stimulation within the tibial nerve distribution at hour @ .
3
1,517
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25248648
2methods
Secondary endpoints included current tolerance at other time points and plantar flexion maximum voluntary isometric contraction ( @ h total ) .
4
1,518
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25248648
4results
At hour @ , tolerance to cutaneous stimulation for limbs receiving @ % ropivacaine was -LSB- mean ( standard deviation ) -RSB- @ ( @ ) vs@ @ ( @ ) mA for limbs receiving @ % -LSB- estimated mean difference @ mA ; @ % confidence interval ( CI ) -@ to @ ; P = @ and @ for lower and upper boundaries , respectively -RSB- .
5
1,519
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25248648
4results
Because the @ % CI fell within the prespecified tolerance @ mA , we conclude that the effect of the two concentration/volume combinations were equivalent .
6
1,520
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25248648
4results
Similar negative findings were found for the secondary outcomes .
7
1,521
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25248648
1conclusions
For continuous popliteal-sciatic nerve blocks , we found no evidence that local anaesthetic concentration and volume influence block characteristics , suggesting that local anaesthetic dose ( mass ) is the primary determinant of perineural infusion effects in this anatomic location .
8
1,522
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25248648
1conclusions
These findings suggest that for ambulatory perineural local anaesthetic infusion-for which there is usually a finite local anaesthetic reservoir-decreasing the basal rate while increasing the local anaesthetic concentration may allow for increased infusion duration without compromising postoperative analgesia .
9
1,523
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24586534
0background
In VOICE , a multisite HIV pre-exposure prophylaxis ( PrEP ) trial , plasma drug levels pointed to widespread product nonuse , despite high adherence estimated by self-reports and clinic product counts .
0
1,524
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24586534
0background
Using a socio-ecological framework ( SEF ) , we explored socio-cultural and contextual factors that influenced participants ' experience of daily vaginal gel and oral tablet regimens in VOICE .
1
1,525
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24586534
2methods
In Johannesburg , a qualitative ancillary study was concurrently conducted among randomly selected VOICE participants assigned to in-depth interviews ( n = @ ) , serial ethnographic interviews ( n = @ ) , or focus group discussions ( n = @ ) .
2
1,526
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24586534
2methods
Audiotaped interviews were transcribed , translated , and coded thematically for analysis .
3
1,527
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24586534
4results
Of the @ participants , the mean age was @ years , and @ % had a primary sex partner with whom @ % cohabitated .
4
1,528
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24586534
4results
Few women reported lasting nonuse , which they typically attributed to missed visits , lack of product replenishments , and family-related travel or work .
5
1,529
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24586534
4results
Women acknowledged occasionally skipping or mistiming doses because they forgot , were busy , felt lazy or bored , feared or experienced side effects .
6
1,530
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24586534
4results
However , nearly all knew or heard of other study participants who did not use products daily .
7
1,531
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24586534
4results
Three overarching themes emerged from further analyses : ambivalence toward research , preserving a healthy status , and managing social relationships .
8
1,532
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24586534
4results
These themes highlighted the profound and complex meanings associated with participating in a blinded HIV PrEP trial and taking antiretroviral-based products .
9
1,533
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24586534
4results
The unknown efficacy of products , their connection with HIV infection , challenges with daily regimen given social risks , lack of support-from partners and significant others-and the relationship tradeoffs entailed by using the products appear to discourage adequate product use .
10
1,534
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24586534
1conclusions
Personal acknowledgment of product nonuse was challenging .
11
1,535
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24586534
1conclusions
This qualitative inquiry highlighted key influences at all SEF levels that shaped women 's perceptions of trial participation and experiences with investigational products .
12
1,536
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24586534
1conclusions
Whether these impacted women 's behaviors and may have contributed to ineffective trial results warrants further investigation .
13
1,537
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24772504
3objective
To improve the quality of eradication therapy ( ET ) , by increasing patient compliance .
0
1,538
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24772504
2methods
An open-label cohort multicenter randomized study was conducted .
1
1,539
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24772504
2methods
A total of @ patients with Helicobacter pylori infection-associated diseases and indications for ET were examined .
2
1,540
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24772504
2methods
Work was done to improve compliance in a study patient group before treatment .
3
1,541
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24772504
4results
In the study group of patients motivated for treatment , the efficiency of ET was significantly higher than in the control group .
4
1,542
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24772504
4results
The factors influencing treatment adherence were identified and methods to optimize compliance during H. pylori eradication were developed .
5
1,543
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24772504
1conclusions
Awareness of the essence of the disease in a patient and his higher motivation for compliance are one of the components of successful H. pylori eradication .
6
1,544
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25113275
3objective
Motor learning results in changes of movement representation in primary motor cortex ( M@ ) a process involving long-term potentiation ( LTP ) .
0
1,545
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25113275
3objective
Pairing motor training with repetitive transcranial magnetic stimulation ( rTMS ) of M@ enhances the formation of a motor memory .
1
1,546
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25113275
3objective
Here we determined the effect of pairing M@ stimulation and the execution of training movements at different times and frequencies on the formation of a motor memory .
2
1,547
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25113275
2methods
Formation of a motor memory was defined as increases in motor evoked potentials ( MEP ) of the training agonist ( extensor carpi ulnaris muscle , ECU ) and increases in peak acceleration of the trained movements that last more than @min .
3
1,548
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25113275
2methods
Training consisted of auditory-paced ballistic wrist extension movements ( @min , @ Hz ) paired with @ , @ or @ Hz subthreshold rTMS .
4
1,549
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25113275
2methods
The rTMS pulse was applied at either the onset , @ms prior to or @ms after the onset of training movement related increases in electromyographic ( EMG ) activity of ECU .
5
1,550
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25113275
2methods
This was compared to a Sham condition .
6
1,551
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25113275
4results
Only @ Hz rTMS applied at the onset of the training related increase in ECU-EMG activity resulted in increases in MEP amplitudes and peak acceleration when compared to the Sham .
7
1,552
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25113275
1conclusions
The formation of motor memory is enhanced above the nave level by co-administration of low frequency rTMS at the time of execution of training movements .
8
1,553
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25113275
1conclusions
These results indicate the importance of time and frequency of rTMS in these settings and should be considered in the design of rehabilitation treatment strategies using rTMS .
9
1,554
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24402888
0background
Various devices have been developed to facilitate liver transection and reduce blood loss in liver resections .
0
1,555
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24402888
0background
None of these has proven superiority compared with the classical clamp-crushing technique .
1
1,556
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24402888
0background
This randomized clinical trial compared the effectiveness and safety of stapler transection with that of clamp-crushing during open liver resection .
2
1,557
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24402888
2methods
Patients admitted for elective open liver resection between January @ and October @ were assigned randomly to stapler transection or the clamp-crushing technique .
3
1,558
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24402888
2methods
The primary endpoint was the total amount of intraoperative blood loss .
4
1,559
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24402888
2methods
Secondary endpoints included transection time , duration of operation , complication rates and resection margins .
5
1,560
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24402888
4results
A total of @ patients were enrolled , @ to clamp-crushing and @ to stapler transection .
6
1,561
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24402888
4results
There was no difference between groups in total intraoperative blood loss : median ( i.q.r. ) @ ( @-@ ) versus @ ( @-@ ) ml respectively ( P = @ ) .
7
1,562
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24402888
4results
The difference in total intraoperative blood loss normalized to the transection surface area was not statistically significant ( P = @ ) .
8
1,563
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24402888
4results
Blood loss during parenchymal transection was significantly lower in the stapler transection group ( P = @ ) , as were the parenchymal transection time ( mean ( s.d. ) @ ( @ ) versus @ ( @ ) min for clamp-crushing and stapler transection groups respectively ; P < @ ) and total duration of operation ( mean ( s.d. ) @ ( @ ) versus @ ( @ ) min ; P = @ ) .
9
1,564
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24402888
4results
There were no significant differences in postoperative morbidity ( P = @ ) or mortality ( P = @ ) between groups .
10
1,565
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24402888
1conclusions
Stapler transection is a safe technique but does not reduce intraoperative blood loss in elective liver resection compared with the clamp-crushing technique .
11
1,566
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25163399
0background
The effect of oral polio vaccine administered already at birth ( OPV@ ) on child survival was not examined before being recommended in @ .
0
1,567
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25163399
0background
Observational data suggested that OPV@ was harmful for boys , and trials have shown that neonatal vitamin A supplementation ( NVAS ) at birth may be beneficial for boys .
1
1,568
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25163399
0background
We set out to test this research question in a randomised trial .
2
1,569
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25163399
2methods
The trial was carried out at the Bandim Health Project , Guinea-Bissau .
3
1,570
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25163399
2methods
We planned to enrol @ low-birth weight ( LBW ) boys in a randomised trial to investigate whether NVAS instead of OPV@ could lower infant mortality for LBW boys .
4
1,571
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25163399
2methods
At birth , the children were randomised to OPV ( usual treatment ) or VAS ( intervention treatment ) and followed for @ months for growth and @ months for survival .
5
1,572
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25163399
2methods
Hazard Ratios ( HR ) for mortality were calculated using Cox regression .
6
1,573
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25163399
2methods
We compared the individual anthropometry measurements to the @ WHO growth reference .
7
1,574
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25163399
2methods
We compared differences in z-scores by linear regression .
8
1,575
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25163399
2methods
Relative risks ( RR ) of being stunted or underweight were calculated in Poisson regression models with robust standard errors .
9
1,576
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25163399
4results
In the rainy season we detected a cluster of deaths in the VAS group and the trial was halted immediately with @ boys enrolled .
10
1,577
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25163399
4results
The VAS group had significantly higher mortality than the OPV@ group in the rainy season ( HR : @ ( @ - @ ) ) .
11
1,578
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25163399
4results
All deaths had had contact with the neonatal nursery ; of seven VAS boys enrolled during one week in September , six died within two months of age , whereas only one died among the six boys receiving OPV ( p = @ ) .
12
1,579
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25163399
4results
Growth ( weight and arm-circumference ) in the VAS group was significantly worse until age @ months .
13
1,580
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25163399
1conclusions
VAS at birth instead of OPV was not beneficial for the LBW boys in this study .
14
1,581
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25163399
1conclusions
With the premature closure of the trial it was not possible to answer the research question .
15
1,582
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25163399
1conclusions
However , the results of this study call for extra caution when testing the effect of NVAS in the future .
16
1,583
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24627301
0background
Dual orexin receptor antagonists ( DORAs ) enable initiation and maintenance of sleep in patients with primary insomnia .
0
1,584
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24627301
0background
Blockade of the orexin system has shown reduction of drug-seeking behavior in animal studies , supporting the role of orexin antagonism as a novel approach for treating substance abuse .
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24627301
0background
Since hypnotics are traditionally associated with misuse , a lack of abuse liability of DORAs would offer significant benefits over current therapies for sleep disorders .
2
1,586
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24627301
2methods
In this randomized , crossover , proof-of-concept study , single oral doses of the DORA almorexant ( @ , @ , and @,@ mg ) were administered to healthy subjects with previous non-therapeutic experience with central nervous system depressants and were compared with placebo and single oral doses of zolpidem ( @ and @ mg ) , a benzodiazepine-like drug .
3
1,587
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24627301
2methods
Subjective measures of abuse potential ( visual analog scales -LSB- VAS -RSB- , Addiction Research Center Inventory , and Subjective Drug Value ) and objective measures ( divided attention -LSB- DA -RSB- ) were evaluated over @ h post-dose in @ evaluable subjects .
4
1,588
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24627301
4results
Drug Liking VAS peak effect ( E max ; primary endpoint ) was significantly higher for all doses of almorexant and zolpidem compared with placebo ( p < @ ) .
5
1,589
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24627301
4results
Almorexant @ mg showed significantly less ` Drug Liking ' than both zolpidem doses ( p < @ ) , and almorexant @ mg had smaller effects than zolpidem @ mg ( p < @ ) , while almorexant @,@ mg was not different from either zolpidem dose .
6
1,590
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24627301
4results
Results were similar for other subjective measures , although almorexant generally showed smaller negative and perceptual effects compared with zolpidem .
7
1,591
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24627301
4results
Almorexant also showed less cognitive impairment compared with zolpidem on most DA endpoints .
8
1,592
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24627301
1conclusions
This study in humans investigating single doses of almorexant is the first to explore and show abuse liability of a DORA , a class of compounds that is not only promising for the treatment of sleep disorders , but also of addiction .
9
1,593
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24256453
3objective
Music therapy is an innovative approach to support people with severe mental illness ( SMI ) .
0
1,594
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24256453
3objective
The aim of the study was to determine whether group music therapy ( GMT ) positively impacted on quality of life ( QoL ) , social enrichment , self-esteem , spirituality and psychiatric symptoms of participants with SMI and how they experienced the intervention .
1
1,595
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24256453
2methods
The primary outcome was QoL ; secondary measures assessed social enrichment , self-esteem , spirituality and psychiatric symptoms .
2
1,596
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24256453
2methods
The @-week intervention comprised singing familiar songs and composing original songs recorded in a professional studio .
3
1,597
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24256453
2methods
Qualitative data were generated from focus group interviews and song lyric analysis .
4
1,598
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24256453
4results
Ninety-nine adults ( @ female ) were recruited , with an initial cohort ( n = @ ) randomized to either : weekly GMT followed by standard care ( SC ) or SC followed by GMT .
5
1,599
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