opentargets/clinical_trial_reason_to_stop · Datasets at Hugging Face

text stringlengths 4 164	label_descriptions sequence	Another_Study bool 2 classes	Business_Administrative bool 2 classes	Covid19 bool 2 classes	Endpoint_Met bool 2 classes	Ethical_Reason bool 2 classes	Insufficient_Data bool 2 classes	Insufficient_Enrollment bool 2 classes	Interim_Analysis bool 2 classes	Invalid_Reason bool 2 classes	Logistics_Resources bool 2 classes	Negative bool 2 classes	No_Context bool 2 classes	Regulatory bool 2 classes	Safety_Sideeffects bool 2 classes	Study_Design bool 2 classes	Study_Staff_Moved bool 2 classes	Success bool 2 classes
Investigator left the site. Site closed.	[ "Study_Staff_Moved" ]	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	true	false
Investigator letter from drug manufacturer stating animal studies showed increased risk of Ê cancer which was an unknown adverse event	[ "Safety_Sideeffects" ]	false	false	false	false	false	false	false	false	false	false	false	false	false	true	false	false	false
Investigator moved to another institution.	[ "Study_Staff_Moved" ]	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	true	false
Investigator moved to new institution	[ "Study_Staff_Moved" ]	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	true	false
Investigator no longer at Cleveland Clinic	[ "Study_Staff_Moved" ]	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	true	false
Investigator's decision:Did not open to enrollment	[ "Invalid_Reason" ]	false	false	false	false	false	false	false	false	true	false	false	false	false	false	false	false	false
Investigators have withdrawn study due to poor subject compliance.	[ "Study_Design" ]	false	false	false	false	false	false	false	false	false	false	false	false	false	false	true	false	false
Investigators no longer interested in activating study	[ "Business_Administrative" ]	false	true	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false
Issue of priority of resources	[ "Logistics_Resources", "Business_Administrative" ]	false	true	false	false	false	false	false	false	false	true	false	false	false	false	false	false	false
Issues w/recruitment	[ "Insufficient_Enrollment" ]	false	false	false	false	false	false	true	false	false	false	false	false	false	false	false	false	false
Issues with CTM stability.	[ "Logistics_Resources" ]	false	false	false	false	false	false	false	false	false	true	false	false	false	false	false	false	false
Issues with data collection tool	[ "Logistics_Resources" ]	false	false	false	false	false	false	false	false	false	true	false	false	false	false	false	false	false
It is too difficult to recruit suitable patients.	[ "Insufficient_Enrollment" ]	false	false	false	false	false	false	true	false	false	false	false	false	false	false	false	false	false
It was decided on 9/21/2016 to terminate this study early because LogPad devices the patientsÊ used to record their injection data was flawed	[ "Logistics_Resources" ]	false	false	false	false	false	false	false	false	false	true	false	false	false	false	false	false	false
It was decided that data from this study are no longer required and therefore it is notÊ necessary to expose patients to the study medication	[ "Business_Administrative" ]	false	true	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false
It was decided to close the study to further enrollment based on data from a similar study using ABT-751 and Pemetrexed that did not show efficacy.	[ "Another_Study" ]	true	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false
It was decided to use a different protocol with a different radioligand	[ "Study_Design" ]	false	false	false	false	false	false	false	false	false	false	false	false	false	false	true	false	false
It was found that the devices were not suitable for the application.	[ "Logistics_Resources" ]	false	false	false	false	false	false	false	false	false	true	false	false	false	false	false	false	false
It was not possible to perform 2 MRI studies in each patient due to practical problems. The study was not suspended due to safety issues.	[ "Logistics_Resources" ]	false	false	false	false	false	false	false	false	false	true	false	false	false	false	false	false	false
It was not possible to recruit enough patients with obstructive sleep apnea.	[ "Insufficient_Enrollment" ]	false	false	false	false	false	false	true	false	false	false	false	false	false	false	false	false	false
It was not possible to recruit new patients anymore	[ "Insufficient_Enrollment" ]	false	false	false	false	false	false	true	false	false	false	false	false	false	false	false	false	false
It was stopped due to a lack of recruitment after 48 patients included	[ "Insufficient_Enrollment" ]	false	false	false	false	false	false	true	false	false	false	false	false	false	false	false	false	false
It was very difficult to enroll patients in this study.	[ "Insufficient_Enrollment" ]	false	false	false	false	false	false	true	false	false	false	false	false	false	false	false	false	false
JNJ-54416076 program has been stopped for strategic business reasons.	[ "Business_Administrative" ]	false	true	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false
Judicial liquidation of the society providing dietary supplementation.	[ "Logistics_Resources" ]	false	false	false	false	false	false	false	false	false	true	false	false	false	false	false	false	false
Just Terminated for the end of the pandemia	[ "Covid19" ]	false	false	true	false	false	false	false	false	false	false	false	false	false	false	false	false	false
LIFE Bronchoscopy equipment no longer functioning and cannot be repaired.	[ "Logistics_Resources" ]	false	false	false	false	false	false	false	false	false	true	false	false	false	false	false	false	false
LOGISTIC DIFFICULTIES	[ "Logistics_Resources" ]	false	false	false	false	false	false	false	false	false	true	false	false	false	false	false	false	false
Lack of Accrual	[ "Insufficient_Enrollment" ]	false	false	false	false	false	false	true	false	false	false	false	false	false	false	false	false	false
Lack of Drug Supply	[ "Logistics_Resources" ]	false	false	false	false	false	false	false	false	false	true	false	false	false	false	false	false	false
Lack of Efficacy	[ "Negative" ]	false	false	false	false	false	false	false	false	false	false	true	false	false	false	false	false	false
Lack of Efficacy.	[ "Negative" ]	false	false	false	false	false	false	false	false	false	false	true	false	false	false	false	false	false
Lack of Enrollment	[ "Insufficient_Enrollment" ]	false	false	false	false	false	false	true	false	false	false	false	false	false	false	false	false	false
Lack of Funding	[ "Business_Administrative" ]	false	true	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false
Lack of Funding/ Resident in charge graduated	[ "Business_Administrative", "Study_Staff_Moved" ]	false	true	false	false	false	false	false	false	false	false	false	false	false	false	false	true	false
Lack of Response	[ "No_Context", "Negative" ]	false	false	false	false	false	false	false	false	false	false	true	true	false	false	false	false	false
Lack of Subject Recruitment	[ "Insufficient_Enrollment" ]	false	false	false	false	false	false	true	false	false	false	false	false	false	false	false	false	false
Lack of Vaccine Supplies	[ "Logistics_Resources" ]	false	false	false	false	false	false	false	false	false	true	false	false	false	false	false	false	false
Lack of accrual	[ "Insufficient_Enrollment", "Insufficient_Data" ]	false	false	false	false	false	true	true	false	false	false	false	false	false	false	false	false	false
Lack of accrual and funding is about to expire.	[ "Logistics_Resources", "Insufficient_Enrollment" ]	false	false	false	false	false	false	true	false	false	true	false	false	false	false	false	false	false
Lack of accrual, study closed."	[ "Insufficient_Enrollment" ]	false	false	false	false	false	false	true	false	false	false	false	false	false	false	false	false	false
Lack of adherence and huge loss of follow up.	[ "Study_Design", "No_Context" ]	false	false	false	false	false	false	false	false	false	false	false	true	false	false	true	false	false
Lack of available clinical drug supply	[ "Logistics_Resources" ]	false	false	false	false	false	false	false	false	false	true	false	false	false	false	false	false	false
Lack of available participants that meet criteria	[ "Insufficient_Enrollment" ]	false	false	false	false	false	false	true	false	false	false	false	false	false	false	false	false	false
Lack of budget	[ "Business_Administrative" ]	false	true	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false
Lack of drug supply	[ "Logistics_Resources" ]	false	false	false	false	false	false	false	false	false	true	false	false	false	false	false	false	false
Lack of drug supply for doxercalciferol for this study	[ "Logistics_Resources" ]	false	false	false	false	false	false	false	false	false	true	false	false	false	false	false	false	false
Lack of efficacy	[ "Negative" ]	false	false	false	false	false	false	false	false	false	false	true	false	false	false	false	false	false
Lack of efficacy and funding to continue investigation	[ "Business_Administrative", "Negative" ]	false	true	false	false	false	false	false	false	false	false	true	false	false	false	false	false	false
Lack of efficacy demonstrated in study ICA-17043-10	[ "Another_Study", "Negative" ]	true	false	false	false	false	false	false	false	false	false	true	false	false	false	false	false	false
Lack of efficacy following an interim analysis	[ "Negative" ]	false	false	false	false	false	false	false	false	false	false	true	false	false	false	false	false	false
Lack of efficacy in European Phase 2 study	[ "Negative" ]	false	false	false	false	false	false	false	false	false	false	true	false	false	false	false	false	false
Lack of efficacy in Multiple myeloma	[ "Negative" ]	false	false	false	false	false	false	false	false	false	false	true	false	false	false	false	false	false
Lack of efficacy.	[ "Negative" ]	false	false	false	false	false	false	false	false	false	false	true	false	false	false	false	false	false
Lack of efficacy/Manufacturer stopping drug development	[ "Business_Administrative" ]	false	true	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false
Lack of eligible participants to enrol	[ "Insufficient_Enrollment", "Study_Design" ]	false	false	false	false	false	false	true	false	false	false	false	false	false	false	true	false	false
Lack of enrollment	[ "Insufficient_Enrollment", "Study_Design" ]	false	false	false	false	false	false	true	false	false	false	false	false	false	false	true	false	false
Lack of enrollment of suitable candidates	[ "Insufficient_Enrollment", "Study_Design" ]	false	false	false	false	false	false	true	false	false	false	false	false	false	false	true	false	false
Lack of enrollment to the trial.Very difficult popultion to recruit.	[ "Insufficient_Enrollment" ]	false	false	false	false	false	false	true	false	false	false	false	false	false	false	false	false	false
Lack of enrollment.	[ "Insufficient_Enrollment" ]	false	false	false	false	false	false	true	false	false	false	false	false	false	false	false	false	false
Lack of enrolment	[ "Insufficient_Enrollment" ]	false	false	false	false	false	false	true	false	false	false	false	false	false	false	false	false	false
Lack of equipoise	[ "Study_Design" ]	false	false	false	false	false	false	false	false	false	false	false	false	false	false	true	false	false
Lack of feasibility due to low recruitment	[ "Insufficient_Enrollment" ]	false	false	false	false	false	false	true	false	false	false	false	false	false	false	false	false	false
Lack of financial support	[ "Business_Administrative" ]	false	true	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false
Lack of financial support. Study criteria severly limited enrollment.	[ "Business_Administrative" ]	false	true	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false
Lack of funding	[ "Business_Administrative", "Logistics_Resources" ]	false	true	false	false	false	false	false	false	false	true	false	false	false	false	false	false	false
Lack of funding prevented the recruitment of 1000 HIV Patients all over India	[ "Logistics_Resources", "Insufficient_Enrollment" ]	false	false	false	false	false	false	true	false	false	true	false	false	false	false	false	false	false
Lack of funding to support clinical trial	[ "Logistics_Resources" ]	false	false	false	false	false	false	false	false	false	true	false	false	false	false	false	false	false
Lack of funding.	[ "Business_Administrative" ]	false	true	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false
Lack of funds	[ "Business_Administrative" ]	false	true	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false
Lack of funds; FDA approved a topical form of diclofenac during study, no need to continue Ê study of pharmacy-compounded drug.	[ "Business_Administrative" ]	false	true	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false
Lack of improved efficacy compared to historical controls, competing studies	[ "Another_Study", "Negative" ]	true	false	false	false	false	false	false	false	false	false	true	false	false	false	false	false	false
Lack of patient accrual	[ "Insufficient_Enrollment" ]	false	false	false	false	false	false	true	false	false	false	false	false	false	false	false	false	false
Lack of patient compliance	[ "Study_Design" ]	false	false	false	false	false	false	false	false	false	false	false	false	false	false	true	false	false
Lack of patient recruitment.	[ "Insufficient_Enrollment" ]	false	false	false	false	false	false	true	false	false	false	false	false	false	false	false	false	false
Lack of patients	[ "Insufficient_Enrollment" ]	false	false	false	false	false	false	true	false	false	false	false	false	false	false	false	false	false
Lack of patients compatible with the protocol__s criteria	[ "Insufficient_Enrollment" ]	false	false	false	false	false	false	true	false	false	false	false	false	false	false	false	false	false
Lack of patients to enroll.	[ "Insufficient_Enrollment" ]	false	false	false	false	false	false	true	false	false	false	false	false	false	false	false	false	false
Lack of patients with a condition of interest that resulted in failure to recruit	[ "Insufficient_Enrollment", "Study_Design" ]	false	false	false	false	false	false	true	false	false	false	false	false	false	false	true	false	false
Lack of patients, lack of funding for analysis"	[ "Business_Administrative" ]	false	true	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false
Lack of personnel	[ "Logistics_Resources" ]	false	false	false	false	false	false	false	false	false	true	false	false	false	false	false	false	false
Lack of personnel to continue	[ "Logistics_Resources" ]	false	false	false	false	false	false	false	false	false	true	false	false	false	false	false	false	false
Lack of recruitment	[ "Insufficient_Enrollment" ]	false	false	false	false	false	false	true	false	false	false	false	false	false	false	false	false	false
Lack of recruitment due to changed therapy options	[ "Study_Design", "Insufficient_Enrollment" ]	false	false	false	false	false	false	true	false	false	false	false	false	false	false	true	false	false
Lack of recruitment/participants	[ "Insufficient_Enrollment" ]	false	false	false	false	false	false	true	false	false	false	false	false	false	false	false	false	false
Lack of recrutment	[ "Insufficient_Enrollment" ]	false	false	false	false	false	false	true	false	false	false	false	false	false	false	false	false	false
Lack of response activity in the setting of an unacceptable toxicity profile	[ "Safety_Sideeffects" ]	false	false	false	false	false	false	false	false	false	false	false	false	false	true	false	false	false
Lack of staff and funding.	[ "Business_Administrative" ]	false	true	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false
Lack of study enrollment	[ "Insufficient_Enrollment" ]	false	false	false	false	false	false	true	false	false	false	false	false	false	false	false	false	false
Lack of study funding & resources	[ "Business_Administrative" ]	false	true	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false
Lack of study population	[ "Insufficient_Enrollment" ]	false	false	false	false	false	false	true	false	false	false	false	false	false	false	false	false	false
Lack of study subjects	[ "Insufficient_Enrollment" ]	false	false	false	false	false	false	true	false	false	false	false	false	false	false	false	false	false
Lack of subject enrollment over the past two years.	[ "Insufficient_Enrollment" ]	false	false	false	false	false	false	true	false	false	false	false	false	false	false	false	false	false
Lack of subject population for PI	[ "Insufficient_Enrollment" ]	false	false	false	false	false	false	true	false	false	false	false	false	false	false	false	false	false
Lack of subject recruitment	[ "Insufficient_Enrollment" ]	false	false	false	false	false	false	true	false	false	false	false	false	false	false	false	false	false
Lack of sufficient funds	[ "Business_Administrative" ]	false	true	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false
Lack of support from pharmaceutical collaborator.	[ "Business_Administrative" ]	false	true	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false
Lack of the subjects	[ "Insufficient_Enrollment" ]	false	false	false	false	false	false	true	false	false	false	false	false	false	false	false	false	false
Lack of volunteers who would consent to participate and lack of funding	[ "Business_Administrative", "Insufficient_Enrollment" ]	false	true	false	false	false	false	true	false	false	false	false	false	false	false	false	false	false
Lapatinib-topotecan arm enrollment closed early per protocol amendment 2. Then enrollment into remaining arm terminated due to operational issues.	[ "Study_Design" ]	false	false	false	false	false	false	false	false	false	false	false	false	false	false	true	false	false

Investigator left the site. Site closed.

[ "Study_Staff_Moved" ]

false

true

false

Investigator letter from drug manufacturer stating animal studies showed increased risk of Ê cancer which was an unknown adverse event

[ "Safety_Sideeffects" ]

false

true

false

Investigator moved to another institution.

[ "Study_Staff_Moved" ]

false

true

false

Investigator moved to new institution

[ "Study_Staff_Moved" ]

false

true

false

Investigator no longer at Cleveland Clinic

[ "Study_Staff_Moved" ]

false

true

false

Investigator's decision:Did not open to enrollment

[ "Invalid_Reason" ]

false

true

false

Investigators have withdrawn study due to poor subject compliance.

[ "Study_Design" ]

false

true

false

Investigators no longer interested in activating study

[ "Business_Administrative" ]

false

true

false

Issue of priority of resources

[ "Logistics_Resources", "Business_Administrative" ]

false

true

false

true

false

Issues w/recruitment

[ "Insufficient_Enrollment" ]

false

true

false

Issues with CTM stability.

[ "Logistics_Resources" ]

false

true

false

Issues with data collection tool

[ "Logistics_Resources" ]

false

true

false

It is too difficult to recruit suitable patients.

[ "Insufficient_Enrollment" ]

false

true

false

It was decided on 9/21/2016 to terminate this study early because LogPad devices the patientsÊ used to record their injection data was flawed

[ "Logistics_Resources" ]

false

true

false

It was decided that data from this study are no longer required and therefore it is notÊ necessary to expose patients to the study medication

[ "Business_Administrative" ]

false

true

false

It was decided to close the study to further enrollment based on data from a similar study using ABT-751 and Pemetrexed that did not show efficacy.

[ "Another_Study" ]

true

false

It was decided to use a different protocol with a different radioligand

[ "Study_Design" ]

false

true

false

It was found that the devices were not suitable for the application.

[ "Logistics_Resources" ]

false

true

false

It was not possible to perform 2 MRI studies in each patient due to practical problems. The study was not suspended due to safety issues.

[ "Logistics_Resources" ]

false

true

false

It was not possible to recruit enough patients with obstructive sleep apnea.

[ "Insufficient_Enrollment" ]

false

true

false

It was not possible to recruit new patients anymore

[ "Insufficient_Enrollment" ]

false

true

false

It was stopped due to a lack of recruitment after 48 patients included

[ "Insufficient_Enrollment" ]

false

true

false

It was very difficult to enroll patients in this study.

[ "Insufficient_Enrollment" ]

false

true

false

JNJ-54416076 program has been stopped for strategic business reasons.

[ "Business_Administrative" ]

false

true

false

Judicial liquidation of the society providing dietary supplementation.

[ "Logistics_Resources" ]

false

true

false

Just Terminated for the end of the pandemia

[ "Covid19" ]

false

true

false

LIFE Bronchoscopy equipment no longer functioning and cannot be repaired.

[ "Logistics_Resources" ]

false

true

false

LOGISTIC DIFFICULTIES

[ "Logistics_Resources" ]

false

true

false

Lack of Accrual

[ "Insufficient_Enrollment" ]

false

true

false

Lack of Drug Supply

[ "Logistics_Resources" ]

false

true

false

Lack of Efficacy

[ "Negative" ]

false

true

false

Lack of Efficacy.

[ "Negative" ]

false

true

false

Lack of Enrollment

[ "Insufficient_Enrollment" ]

false

true

false

Lack of Funding

[ "Business_Administrative" ]

false

true

false

Lack of Funding/ Resident in charge graduated

[ "Business_Administrative", "Study_Staff_Moved" ]

false

true

false

true

false

Lack of Response

[ "No_Context", "Negative" ]

false

true

false

Lack of Subject Recruitment

[ "Insufficient_Enrollment" ]

false

true

false

Lack of Vaccine Supplies

[ "Logistics_Resources" ]

false

true

false

Lack of accrual

[ "Insufficient_Enrollment", "Insufficient_Data" ]

false

true

false

Lack of accrual and funding is about to expire.

[ "Logistics_Resources", "Insufficient_Enrollment" ]

false

true

false

true

false

Lack of accrual, study closed."

[ "Insufficient_Enrollment" ]

false

true

false

Lack of adherence and huge loss of follow up.

[ "Study_Design", "No_Context" ]

false

true

false

true

false

Lack of available clinical drug supply

[ "Logistics_Resources" ]

false

true

false

Lack of available participants that meet criteria

[ "Insufficient_Enrollment" ]

false

true

false

Lack of budget

[ "Business_Administrative" ]

false

true

false

Lack of drug supply

[ "Logistics_Resources" ]

false

true

false

Lack of drug supply for doxercalciferol for this study

[ "Logistics_Resources" ]

false

true

false

Lack of efficacy

[ "Negative" ]

false

true

false

Lack of efficacy and funding to continue investigation

[ "Business_Administrative", "Negative" ]

false

true

false

true

false

Lack of efficacy demonstrated in study ICA-17043-10

[ "Another_Study", "Negative" ]

true

false

true

false

Lack of efficacy following an interim analysis

[ "Negative" ]

false

true

false

Lack of efficacy in European Phase 2 study

[ "Negative" ]

false

true

false

Lack of efficacy in Multiple myeloma

[ "Negative" ]

false

true

false

Lack of efficacy.

[ "Negative" ]

false

true

false

Lack of efficacy/Manufacturer stopping drug development

[ "Business_Administrative" ]

false

true

false

Lack of eligible participants to enrol

[ "Insufficient_Enrollment", "Study_Design" ]

false

true

false

true

false

Lack of enrollment

[ "Insufficient_Enrollment", "Study_Design" ]

false

true

false

true

false

Lack of enrollment of suitable candidates

[ "Insufficient_Enrollment", "Study_Design" ]

false

true

false

true

false

Lack of enrollment to the trial.Very difficult popultion to recruit.

[ "Insufficient_Enrollment" ]

false

true

false

Lack of enrollment.

[ "Insufficient_Enrollment" ]

false

true

false

Lack of enrolment

[ "Insufficient_Enrollment" ]

false

true

false

Lack of equipoise

[ "Study_Design" ]

false

true

false

Lack of feasibility due to low recruitment

[ "Insufficient_Enrollment" ]

false

true

false

Lack of financial support

[ "Business_Administrative" ]

false

true

false

Lack of financial support. Study criteria severly limited enrollment.

[ "Business_Administrative" ]

false

true

false

Lack of funding

[ "Business_Administrative", "Logistics_Resources" ]

false

true

false

true

false

Lack of funding prevented the recruitment of 1000 HIV Patients all over India

[ "Logistics_Resources", "Insufficient_Enrollment" ]

false

true

false

true

false

Lack of funding to support clinical trial

[ "Logistics_Resources" ]

false

true

false

Lack of funding.

[ "Business_Administrative" ]

false

true

false

Lack of funds

[ "Business_Administrative" ]

false

true

false

Lack of funds; FDA approved a topical form of diclofenac during study, no need to continue Ê study of pharmacy-compounded drug.

[ "Business_Administrative" ]

false

true

false

Lack of improved efficacy compared to historical controls, competing studies

[ "Another_Study", "Negative" ]

true

false

true

false

Lack of patient accrual

[ "Insufficient_Enrollment" ]

false

true

false

Lack of patient compliance

[ "Study_Design" ]

false

true

false

Lack of patient recruitment.

[ "Insufficient_Enrollment" ]

false

true

false

Lack of patients

[ "Insufficient_Enrollment" ]

false

true

false

Lack of patients compatible with the protocol__s criteria

[ "Insufficient_Enrollment" ]

false

true

false

Lack of patients to enroll.

[ "Insufficient_Enrollment" ]

false

true

false

Lack of patients with a condition of interest that resulted in failure to recruit

[ "Insufficient_Enrollment", "Study_Design" ]

false

true

false

true

false

Lack of patients, lack of funding for analysis"

[ "Business_Administrative" ]

false

true

false

Lack of personnel

[ "Logistics_Resources" ]

false

true

false

Lack of personnel to continue

[ "Logistics_Resources" ]

false

true

false

Lack of recruitment

[ "Insufficient_Enrollment" ]

false

true

false

Lack of recruitment due to changed therapy options

[ "Study_Design", "Insufficient_Enrollment" ]

false

true

false

true

false

Lack of recruitment/participants

[ "Insufficient_Enrollment" ]

false

true

false

Lack of recrutment

[ "Insufficient_Enrollment" ]

false

true

false

Lack of response activity in the setting of an unacceptable toxicity profile

[ "Safety_Sideeffects" ]

false

true

false

Lack of staff and funding.

[ "Business_Administrative" ]

false

true

false

Lack of study enrollment

[ "Insufficient_Enrollment" ]

false

true

false

Lack of study funding & resources

[ "Business_Administrative" ]

false

true

false

Lack of study population

[ "Insufficient_Enrollment" ]

false

true

false

Lack of study subjects

[ "Insufficient_Enrollment" ]

false

true

false

Lack of subject enrollment over the past two years.

[ "Insufficient_Enrollment" ]

false

true

false

Lack of subject population for PI

[ "Insufficient_Enrollment" ]

false

true

false

Lack of subject recruitment

[ "Insufficient_Enrollment" ]

false

true

false

Lack of sufficient funds

[ "Business_Administrative" ]

false

true

false

Lack of support from pharmaceutical collaborator.

[ "Business_Administrative" ]

false

true

false

Lack of the subjects

[ "Insufficient_Enrollment" ]

false

true

false

Lack of volunteers who would consent to participate and lack of funding

[ "Business_Administrative", "Insufficient_Enrollment" ]

false

true

false

true

false

Lapatinib-topotecan arm enrollment closed early per protocol amendment 2. Then enrollment into remaining arm terminated due to operational issues.

[ "Study_Design" ]

false

true

false