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Just a small add on. When you first inflate the tyre, leave the valve insert out. It restricts the air flow into the tyre. Inflate the tyre to around 50-60 psi, and then let it go completely flat again. Then re inflate it with the valve insert in place to the correct pressure. This helps to get the tyres bead nice and even on the rim. current bike. 2010 R1200GS. 83000 km and going as good as new. This is great if your in a shop. I would love to see a tutorial on tire change out on the trail with hand tools. Yes, YouTube is crawling with great works of fiction in which people easily slip tires on and off in seconds, with nothing more than a few tire irons and a bottle of Dawn dish detergent. If I did not know one person in the real world who can do this trick (even with those stiff-sided, bias-ply Harley touring tires), I would think the videos are fakes. Still, the fact that some people have some natural talent for this (or have sold their souls in return for the ability to do it) does not mean that a mere mortal like me can change a tire. I fell for the allure of the Harbour Freight tire changer some years back when I owned a Buell that consumed tires like they were potato chips. And, after a while, I got minimally competent at changing the tires on that bike... if you accept that sweating and cussing for forty-five minutes to remove and replace a soft-sided radial sportbike tire, using a tire mounting machine, is a form of "competence." This is one of the reasons I no longer have my KLR650: I had a flat tire on that bike, and the only thing I could do was call for help. Luckily I was near my favorite repair shop, and so I didn't end up paying a hundred bucks for them to come and get me (and their bike-rescue rig, with a crane that picks up and sets down a pallet with a set of wheel chocks and tie-down straps, was such a great show it was almost worth the service call just to see it in action). But what if I on some dirt forest road in the middle of nowhere? I'd be buzzard food, that's what. So now I have a GS, with tubeless tires that I can repair (assuming they're not slashed wide open) by the roadside. Not a simple process, but! I've been doing my own 705 to save a few $ plus local dealer won't do mine any more (they bought me a new wheel)and it's 50 miles to the nearest aftermarket shop that will mount and balance a tire they didn't sell! Y'know, with all the seminars and training they're planning for the MOA national rally, they ought to have a hands-on side-of-the-trail tire/tube repair class. I'd sign up for that in a minute! I ran Shinko 705s on my KLR before I replaced it with the GS. Nice tires. Decent enough on forest roads, good on pavement, confident in the rain. Cheap. Unfortunately, short-lived enough that if I don't install them myself they don't work out to be particularly cheaper per-mile than longer-lived, more-expensive tires. May have to learn to mount my own tires anyway, because my favorite indy shop changed their policy over the winter and now charges an extra $15 to mount a tire that wasn't bought from them... and their supplier doesn't carry Shinko, Heidenau, Mitas, etc. (they do carry Michelin Anakee IIIs, not sure about Continental TKC70s). Last edited by saughblade; 12-Jun-2018 at 07:20 AM (514). FWIW I get about 8K miles per 705 on my GS. I could get more. I do install my own tires. This was the rear tire I last replaced after a little more than 8K miles. I replaced it before a trip. If not for the trip I'd have run it a little bit longer. I get 4K miles rear and double that front. New tires every couple months Thus I do my own mounting and balancing. Thank you for this thread Jim. I have been going through a slew of nail flats lately(see your plug thread)and have thought I should learn this myself. I do my own Kart tires, but have never given my bike tires a shot. Now I will. P.S. Thanks for doing the Maint. DVD! Saved me $190.00 last weekend by doing my own valves and throttle body sync. The DVD was money well spent! Hi. You referenced a maintenance DVD. Where can I find that?

2019-04-20T19:02:28Z

Let’s take a look at why you may want to use React and how to set up a basic interface. You can download all of the files associated with this tutorial from here . If you are keen to learn React from the ground-up feel free to check Learn and Understand React JS on Zenva Academy which covers all the basics + lots of bonus topics like React Router and Flux. You will need to download the React library if you want to go beyond the testing phase. We show you how to get around this during testing. You will need a text editor of some sort. Notepad++ is popular for those on Windows machines, and TextMate is popular on a Mac. Editors that highlight code are preferable. Normally, you would incorporate React into a larger application. If you want to test the basic code with external data files at the end of the tutorial, you will need to use a local or remote web server to get the page to work. MAMP is popular on Mac, and WAMP is most common on Windows machines. You can also use a lightweight Mongoose web server, or Python’s HTTP server. Many people use React with Node.js, so you can also use a Node.js server. The React library download page (above) also includes a server and other options. Both the download pages go into detail on the various ways to download, install, and serve React in various formats, but we’re going to stick with this most basic option so we can focus on learning how to code with the React library itself. It’s a good idea to have the React API open while you work for reference. As you can see, the JSX code is much easier to read. Now that we have a basic understanding of what our output syntax will look like, let’s dig in and learn the building blocks of React. React is based on components and states. This is what makes React such a popular library. When you want to create an application, you usually break it into simpler parts. When programming with React, you will want to break your interface into its most basic parts, and those will be your React components. Components are wonderful because they are modular and reusable. You can take a basic component used in one area of an application and reuse it in others without having to duplicate code. This helps to speed up development. Components can be nested, so that the most basic components can be grouped into a parent component. For example, if you were to create a home listing interface with React, the top level component would be the home list itself. Within the list, you would have a description of a single home. Within the home component, you would have the address of the home, as well as other small components such as a photo, perhaps a favorite or save button, and a link to view details and a map. Now let’s see how this information can be updated when it changes. Component states are what give React its name. Any time a component’s state changes, its “render” function is called, updating the output. In essence, each component “reacts” to changes, which is handy for any user interface. Data stored in a state should be information that will be updated by the component’s event handlers (changes that should update in real time as the interface is being used). If we were to have a home listing, any number of things may change in the database. New photos could be added, and a home can be bought and sold. You wouldn’t necessarily want any of these things to update in real time in the interface. This won’t actually do anything yet, because we don’t have any statement to call on Saves. Still, this component describes what we do with components and states. You also won’t find this code anywhere in the files, because we will have to move things around a bit to make it work the way we want, but this is fine for now. You may notice a naming convention right away. Most element names start with a lowercase letter, followed by capitalization. The names of React classes, however, begin with an uppercase letter. We then have the React.createClass() function, which creates our component. Save the addition of the string for the render function. All we want to save in the state is the data that gets updated by the component’s event handler, and that is simply the number of favorites. Because we are dealing with states, we need to set an initial state so that the state variables will always be available in the render method without errors. This is why we use the getInitialState() method at the top of the component. The handleSubmit function is where we handle the pressing of the Save (or Remove) button. We first have to call preventDefault() in order to prevent the form from being submitted the normal way. We then process the data, so that the user will save the home if it’s not already saved, or remove it from their saves if it is saved. As soon as we save the new state at the end of the function, the render method will be called automatically, which will update the display. Now, let’s look at the rest of the example in more detail. Components pass properties to their children components through the use of props. One thing to keep in mind is that props should never be used to determine the state of a component. A property would be something such as the address of a home, passed from the listing component to the individual home component. The state, on the other hand, should depend on data that may be updated, such as the number of times people have saved the home. For this basic example, we are just going to hard-code a home listing. It all starts at the bottom, where we have the ReactDOM.render() call. Version 0.14 of React separated React into two modules: React and ReactDOM. ReactDOM exposes DOM-specific methods, and React includes the core tools shared by React on different platforms. <HomeListing /> is basically a call to a component, in XML-style code. The naming convention states that regular HTML code is lowercase, while component names are capitalized. Everything will be placed in the “content” tag, which is included in the index.html file. The Home component is where we see our first use of props. Basically, any custom attribute sent through when calling a child component may be accessed through this.props. The most unique of these is this.props.children. The “children” property accesses whatever was included within the opening and closing tags of the call to the component (not including the attributes). Notice in the call to the Home component that we include a “key” attribute, as well as an “id” attribute with the same value. The key is used internally by React, and is not available as a prop. It allows React to keep track of components that may be shuffled or removed. Since we also need some sort of id for our application, we pass in a second “id” attribute with the same value, which may be used as a prop. It pretty much looks like what we want, doesn’t it? Well, not so fast. As you can see from the Saves component (which we discussed above), all the action is happening right here. The output shows that 52 people have saved the home before you. The problem is, how does the application save any new information. How will it “remember” that you saved the home too? This is where things get just a little more complicated. First of all, you would normally include React as one piece of a larger app that will do all the processing of the data, where data is pulled from a database or file, then saved back to the database or file as the interface is being used. For now, we can hard-code this data as JSON, and show you at what point the data would be saved at the other end. What we need to do is pull data from the top level component, and save data at the top level as well. This is because the total number of saves is being shared with all users. If our application was sharing information that is only relevant to each individual user, we could pull and save data in a child component, because what other people see wouldn’t matter. //We're going to hard-code this information for testing purposes. //as a prop, so we need a separate id for that. //since that is where the entire list resides. The first difference here is that React.render() calls on the HomeListing component using a few attributes. These attributes are not being used at the moment, because that would require the use of a server of some sort (see the requirements section above for links). You can easily move the homes data to a homes.json file, and the saves data to a saves.json file. Another option is to create some database calls to pull the data, and save the updated data. You’ll now see that the HomeListing component does all the work. The reason we have separated the saves information from the homes information is that we don’t want to update changes to the homes in real time. Changes to home information just don’t happen often enough to make it worth the cost in resources to update every single thing on the page. It’s pretty much the same as the old output, except that the interface now works properly! We still aren’t saving the data, but you’ll see that there is a comment in the toggleSave() function (which is a custom function), showing where you would save the new data to a database, or to a json file. We also make use of the React method componentDidMount(). This method is automatically called once when the component has finished rendering. This is the perfect place to load our information. It’s also the best place to put any polling function, such as the setInterval function, for updating any changes to the saves in real time. You’ll also see that the custom load functions, which include JSON-style data, have a setState() call at the end. Even though we won’t be updating the home data in real time, setting it in a state makes it easier to populate the output with the correct data after the component is loaded. The reason we separate the saves into another state is so that you can comment out the setInterval() call to update only the save data in real time, and nothing else. The interval time can be sent through props, as it is in the call to HomeListing. In the HomeListing render() method, we map out all the data to include each individual call to the Home component, along with all the attributes for each. We have to set some variables to anything that uses “this” which need to be accessed within the map method, because they are outside its scope. You’ll also notice that there is a new attribute that is set to our custom toggleSave() function. That is how we are going to save information updates initiated in child components. The child component must call the parent function using props. In the Home component, you’ll see that the toggleSave() custom function calls this.props.onToggleSave(index). I deliberately made the names different to show that you must call the function using the attribute name that was passed in rather than the actual name of the function in HomeListing. Note that the toggleSave() function call could have been passed directly through as another props value, but we can also do as we did here and call a local function first, which then calls the parent function through props. That gives you the ability to make any additional changes. Do you have any questions about this article, or about React.js in general? What else would you like me to write about? Let me know in the comments section below. How do you run the application? You write each component in a JS file, but then how do you execute it for the final output, without npm I mean? You can download all of the files associated with this tutorial from here.

2019-04-22T11:06:24Z

Home Health Care in Reform, AL can be categorized as either non-medical (home care) or Medicare certified (home health). Non-medical home care includes personal care and help with everyday activities, while Medicare certified home health involves skilled nursing and rehabilitation. Elderly residents of Reform, AL may require home health after an injury or illness, whereas non-medical home care is provided long-term to seniors with declining physical and mental abilities. This directory includes agencies near Reform, AL and the surrounding areas. It's not uncommon for agencies to cover multiple counties. Pay close attention to minimum hours and affiliations / recognitions. Call to compare rates and keep in mind that the average cost of a home health aide in Reform, AL is $17 per hour (according to John Hancock's 2016 Cost of Care Survey). Finally, contact your local Area Agency on Aging to ask about family caregiver respite and senior transportation services.

2019-04-19T10:31:44Z

GreatWhite – Once Bitten, Twice Shy (Ian Hunter Cover) – Live at Rock USA in Oshkosh, WI on Thursday, July 18th, 2013. Live at Sally’s High River Ab April 2 2011. Great-White Cover – Rock Band from Red Oak, Texas. Im back after a break! please enjoy!!! AND im doing a piano solo!!! i was able to learn the piano by ear!! My version of this great Intro. Recorded Live @ flip flops 7/12/14. A guitarra no das melhores, o guitarrista tambm no. O resultado saiu at razoavel. Agradecimentos ao meu brother Lucas que me emprestou a pedaleira. Great-White „Money (That’s What I Want)“ (Barrett Strong cover) 02-02-1988 The Ritz New York,NY. Meine eigene Aufnahme des Great-White-Klassikers aus den 80er Jahren. Alle E-Gitarren, Bass, Drums und Gesang sind von mir. Great-White – Sin City live Osaka. I’m covering this song in remembrance of my uncle this was one of his favorite songs. Nathan Alan Peters, Rest In Paradise. Coverversion of Paramore’s Still Into You at OOOM@*SCAPE, 13th of Sep 2014. Vocals: Melina K Guitars: Marc & Jon – Like our Facebook page! This is a great tune by Great White. taken from Great-White -Ready To Rock N Roll Digipak-CD. released by Collectors Dream Records. catalogue number: CDR DP0008 . Great White – „Since I’ve Been Loving You“ (Led Zeppelin Cover) Great-White 02-02-1988 The Ritz New York,NY. Live Performance Video….ENJOY AND SUBSCRIBE!!

2019-04-24T11:48:47Z

The Pineapple trend is hitting the bar industry hard. Everybody seems to love them! Pick olives, cherries and other cocktail garnishes with these elegant pineapple cocktail picks.

2019-04-25T00:35:33Z

A new study finds that more LGBTQ people living in the United States have been murdered so far this year than in 2016. So this video is my response to this study. I am a gay, Muslim, Arab-American man. I am a gay, Muslim, Arab-American man.

2019-04-21T12:33:42Z

A princess needs her fairy godmother to help her chose the right prince. She expects that she’ll know him as soon as he rides up her drive in his shining armor riding his brilliant white steed. But real life isn’t like a fairy tale. Sometimes the armor and steed are a disguise. Maybe, just maybe, if this princess were to take the advice of her fairy godmother she’d know her knight when he arrived. More importantly – she’d see through the disguises of the others. I wish I could have read and taken this book to heart as a teen. It’s a quick and easy read that reminds each of us that our Knight in Shining Armor should not complete us but enhance the person we already are. It really irks me when I see teens, and some adults, expecting another person to ‘fix’ them. Back then she thought her life would be perfect once her Knight in Shining Armor came along. Wasn’t that what her mother had always taught her? Wasn’t that how all of her storybooks ended? She knew now that happily-ever-after wouldn’t simply meet her at the end of the aisle. Honestly, the only thing I didn’t like it that the author believes it’s all totally us whereas I believe that God is what completes us. However, even with that – I will be keeping this book and sharing it with my daughter until she truly gets it! I think I’m going to mark this as a future read for my girl too! Great review sweetie.

2019-04-19T02:16:25Z

Appropriately, this review summarizes the data for translating basic scientific concepts underlying circulatory and device-associated vascular problems for the clinical development and usage of cardiac devices, supplemented simply by findings through the literature. Insights for platelet receptor activation, inflammatory cell biology, endothelial dysregulation, and the consequences of biomechanical tension on coagulation and hemostatic protein were examined to raised determine the pathobiology, occurrence, and possible avoidance of adverse occasions in patients getting cardiac devices. Shear Tension and Platelet Activation Hemodynamics play an integral function in thrombus development. Pathophysiological shear tension induces activation of platelets as well as the endothelium, boosts plateletCleukocyte connections, and promotes thrombin era. The original tethering of moving activated platelets, following steady adhesion, and aggregation each are inspired by shear pressure on the vessel wall structure, which can range between 11.4 to 30.4 dyne/cm2 in huge arteries or more to 380 dyne/cm2 at critical regions of arterial stenosis.1 Along a diseased vessel, shear forces will change dramatically within brief ranges, increasing as the lumen narrows and decreasing in the poststenotic vascular portion.2 Many platelet membrane proteins serve as mechanosensors, especially glycoprotein (GP) Ib and its own ligand, von Willebrand factor (vWF).3 vWF circulates as highly adhesive multimers (ultralarge vWF) that are cleaved with a disintegrin and metalloproteinase with thrombospondin type 1 theme member 13 (ADAMTS-13). Depletion or deposition of ultralarge vWF, because of unacceptable ADAMTS-13 proteolysis, leads to pathological blood loss (as in a few sufferers with type 2A von Willebrand disease) or microvascular thrombosis (much like thrombotic thrombocytopenic purpura), respectively. Shearing forces control vWF multimer size by unfolding a Tyr1605CFulfilled1606 bond inside the vWF-A2 domain so that it turns into a substrate for ADAMTS-13 cleavage.3C6 Platelet GP Ib responds to raised shear with an increase of vWF binding and intracellular signaling, partly by producing a calcium flux7 that as well as phosphoinositide 3-kinase8 triggers integrin IIb3 activation.7,9 These alerts convert transient platelet surface area interactions into steady integrin-mediated adhesion. During shear-induced platelet activation in vitro, released adenosine diphosphate (ADP) has a fundamental function in this essential process. Temporal shear gradients promote cooperative signaling between your purinergic P2Y1 receptor and integrin IIb3,10,11 which contributes to the introduction of P2Y12-reliant steady platelet thrombi.11 Shear tension dissociates integrin IIb3Ccytoskeletal proteins interactions, including associations with -actin and myosin large stores,12 although the results of the disruption are unidentified. Many factors stabilize shaped platelet aggregates. The intercellular space between aggregating platelets offers a defensive environment for deposition of ADP, thrombin, thromboxane A2, Gas-6, and exodomains of platelet surface area proteins such as for example GP Ib, Compact disc62, and soluble Compact disc40 ligand.13 The contributions from the II1, P2Y1, P2Y12, and IIb3 integrins may also be critical to development of steady thrombi.14C17 Accordingly, agencies targeting these last mentioned receptors may reduce existing thrombus burden,18,19 although increased intracoronary dosage levels could be essential to dissolve instead of prevent thrombus.20 The consequences of shear on platelets might extend beyond acute activation and thrombosis. Platelets possess played a job in atherosclerosis initiation and/or development in animal versions, although the precise function of platelet activation continues to be uncertain.21,22 Inhibition of platelet activation, vWF insufficiency, GP Ib blockade, and IIb insufficiency all show protective results against atherogenesis in mice.23C25 In a report of recombinant platelet GP Ib as the focusing on entity on lipid-shelled decafluorobutane microbubbles to identify activated vWF and other GP Ib ligands, Lindner et al26 recognized microbubble accumulation along thrombi formed by ex vivo perfusion of human 936563-96-1 supplier blood vessels more than a collagen surface area and along atherosclerotic vessels. In atherosclerotic mice, transmission strength similarly was best in areas with serious 936563-96-1 supplier atherosclerotic lesions and in areas connected with platelet accumulation. Oxidation of vWF by oxidants produced from inflammatory leukocytes may render vWF more steady, with enhanced platelet binding and aggregatory impacts.27 The combined ramifications of shear and swelling on vWF-platelet binding highlights the organic interplay among shear tension, swelling, and plateletCleukocyte activation (Number 1). Additional shear/platelet/inflammatory relationships are unquestionably at play at the website of atherosclerotic lesions, like the development of plateletCleukocyte heterotypic aggregates induced by shear-mediated P-selectin induction in platelets.28 Other ramifications of shear on vascular inflammation are further analyzed elsewhere.29 Open in another window Figure 1 Organic interplay among shear stress, inflammation, and plateletCleukocyte activation. vWF shows von Willebrand element; RBC, red bloodstream cell; PSGL, P-selectin glycoprotein ligand; GP, glycoprotein; PKC, proteins kinase C; TGF, changing growth aspect; and ADP, adenosine diphosphate. In Vivo and In Vitro Modeling of Platelet Function Under Shear A lot of the common methods for assessment platelet function usually do not accurately reflect in vivo occasions occurring along vascular areas in the current presence of streaming blood. Also putative markers for in vivo platelet activationplatelet microparticles, -thromboglobulin, and thromboxane display poor reproducibility.30 Testing of platelet activatability, such Itga2 as for example classic aggregation testing, flow cytometry, VerifyNow point-of-care testing, as well as the MultiPlate system, depend on low-shear settings that might not accurately imitate the high-shear environment present within diseased arteries. Several ways of model and monitor platelets under even more physiological circumstances, including animal versions, imaging in human beings, and in vitro stream are now used, an array of which is certainly summarized in Desk 1. Table 1 Benefits and drawbacks of Selected In Vitro and In Vivo Strategies Utilized to Measure Platelet Activation* and development of the statement were supported by unrestricted grants or loans from Abbott Vascular, Inc, Redwood Town, CA; AstraZeneca, PLC, Wilmington, DE; Boston Scientific Company, Natick, MA; Daiichi Sankyo, Inc, and Lilly USA LLC Collaboration, Parsippany, NJ; Medtronic Cardiovascular, Minneapolis, MN; Regado Biosciences, Inc, Durham, NC; St Jude Medical, Inc, St Paul, MN; as well as the Medicines Organization, Parsippany, NJ. This materials is the consequence of function supported using the assets and usage of the services in the Lexington Veterans Affairs INFIRMARY (Dr Smyth). The material usually do not represent the sights from the Division of Veterans Affairs or the government. Footnotes Disclosures Dr Finn provides received grants or loans from Boston Scientific, Medtronic, and St Jude Medical and provides consulted for Abbott Vascular. Patricia French provides consulted for Regado Biosciences. Dr Jennings provides received grants or loans from Atrium Medical, AstraZeneca, and Merck; provides participated in speaker’s bureaus for BMS/sanofi-aventis and Merck; provides received honoraria from AstraZeneca and Merck; and provides consulted for BMS/sanofi-aventis, Merck, and Portola Pharmaceuticals. Dr Gross provides received research grants or loans in the Canadian Institutes for Wellness Research, the Center and Stroke Base of Ontario, and Canadian Bloodstream Services; provides participated in speaker’s bureaus for Bayer and Leo Pharma; and continues to be an expert see for Apotex. Dr Steinhubl is certainly a former worker of The Medications Firm. Dr Zimmerman provides received grants or loans from Boehringer-Ingelheim and NovoNordisk. Dr Becker 936563-96-1 supplier provides received grants or loans from AstraZeneca, Bayer, and Regado Biosciences; provides received honoraria from Johnson & Johnson and Regado Biosciences; and provides consulted for Daiichi/Lilly and Boehringer-Ingelheim. Dr Dauerman provides received research grants or loans from Abbott Vascular, Medtronic, and MDS Scientific; provides consulted for Abbott Vascular, Medtronic, MDS Scientific, Novartis, The Medications Firm, Gilead, and St Jude Medical; and provides served as a specialist defense see in New Hampshire. Dr Smyth provides received grants or loans from AstraZeneca, The Medications Firm, and Boehringer-Ingelheim and offers consulted for BMS/sanofi-aventis. The online-only Data Health supplement is available with this informative article at http://circinterventions.ahajournals.org/lookup/suppl/doi:10.1161/CIRCINTERVENTIONS.111.965426/-/DC1.. preliminary tethering of moving activated platelets, following steady adhesion, and aggregation each are affected by shear pressure on the vessel wall structure, which can range between 11.4 to 30.4 dyne/cm2 in huge arteries or more to 380 dyne/cm2 at critical regions of arterial stenosis.1 Along a diseased vessel, shear forces will change dramatically within brief ranges, increasing as the lumen narrows and decreasing in the poststenotic vascular section.2 Several platelet membrane protein serve as mechanosensors, especially glycoprotein (GP) Ib and its own ligand, von Willebrand element (vWF).3 vWF circulates as highly adhesive multimers (ultralarge vWF) that are cleaved with a disintegrin and metalloproteinase with thrombospondin type 1 theme member 13 (ADAMTS-13). Depletion or build up of ultralarge vWF, because of unacceptable ADAMTS-13 proteolysis, leads to pathological blood loss (as in a few individuals with type 2A von Willebrand disease) or microvascular thrombosis (much like thrombotic thrombocytopenic purpura), respectively. Shearing makes regulate vWF multimer size by unfolding a Tyr1605CMet1606 relationship inside the vWF-A2 site so that it turns into a substrate for ADAMTS-13 cleavage.3C6 Platelet GP Ib responds to raised shear with an increase of vWF binding and intracellular signaling, partly by producing a calcium flux7 that as well as phosphoinositide 3-kinase8 triggers integrin IIb3 activation.7,9 These signs convert transient platelet surface area interactions into steady integrin-mediated adhesion. During shear-induced platelet activation in vitro, released adenosine diphosphate (ADP) takes on a fundamental part in this essential procedure. Temporal shear gradients promote cooperative signaling between your purinergic 936563-96-1 supplier P2Y1 receptor and integrin IIb3,10,11 which contributes to the introduction of P2Y12-reliant steady platelet thrombi.11 Shear tension dissociates integrin IIb3Ccytoskeletal proteins interactions, including associations with -actin and myosin weighty stores,12 although the results of the disruption are unfamiliar. Several elements stabilize created platelet aggregates. The intercellular space between aggregating platelets offers a protecting environment for build up of ADP, thrombin, thromboxane A2, Gas-6, and exodomains of platelet surface area proteins such as for example GP Ib, Compact disc62, and soluble Compact disc40 ligand.13 The contributions from the II1, P2Y1, P2Y12, and IIb3 integrins will also be critical to development of steady thrombi.14C17 Accordingly, brokers targeting these second option receptors may reduce existing thrombus burden,18,19 although increased intracoronary dosage levels could be essential to dissolve instead of prevent thrombus.20 The consequences of shear on platelets might lengthen beyond severe activation and thrombosis. Platelets possess played a job in atherosclerosis initiation and/or development in animal versions, although the precise function of platelet activation continues to be uncertain.21,22 Inhibition of platelet activation, vWF insufficiency, GP Ib blockade, and IIb insufficiency all show protective results against atherogenesis in mice.23C25 In a report of recombinant platelet GP Ib as the focusing on entity on lipid-shelled decafluorobutane microbubbles to identify activated vWF and other GP Ib ligands, Lindner et al26 recognized microbubble accumulation along thrombi formed by ex vivo perfusion of human blood vessels more than a collagen surface area and along atherosclerotic vessels. In atherosclerotic mice, transmission strength similarly was best in areas with serious atherosclerotic lesions and in areas connected with platelet build up. Oxidation of vWF by oxidants produced from inflammatory leukocytes can render vWF even more stable, with improved platelet binding and aggregatory impacts.27 The combined ramifications of shear and swelling on vWF-platelet binding highlights the organic interplay among shear tension, swelling, and plateletCleukocyte activation (Determine 1). Additional shear/platelet/inflammatory relationships are unquestionably at play at the website of atherosclerotic lesions, like the development of plateletCleukocyte heterotypic aggregates induced by shear-mediated P-selectin induction in platelets.28 Other ramifications of shear on vascular inflammation are further analyzed elsewhere.29 Open up in another window Determine 1 Organic interplay among shear pressure, inflammation, and plateletCleukocyte activation. vWF shows von Willebrand element; RBC, red bloodstream cell; PSGL, P-selectin glycoprotein ligand; GP, glycoprotein; PKC, proteins kinase C; TGF, changing growth element; and ADP, adenosine diphosphate. In Vivo and In Vitro Modeling of Platelet Function Under Shear A lot of the traditional methods for tests platelet function usually do not accurately reveal in vivo occasions taking place along vascular areas in the current presence of moving blood. Also putative markers for in vivo platelet activationplatelet microparticles, -thromboglobulin, and thromboxane display poor reproducibility.30 Testing of platelet activatability, such as for example classic aggregation. Objectives Polymorphonuclear neutrophils (PMN) in atherosclerotic plaques have already been identified just recently, and their contribution to plaque advancement isn’t yet fully comprehended. IL-8 mRNA was higher at rest but lower after fMLP (P 0.01 vs HS), and VEGF mRNA was higher both at rest and after fMLP (P 0.01 vs HS), while elastase mRNA had not been significantly different. On the other hand, protein creation was usually higher in cPMN buy 344458-19-1 of HS regarding values assessed in cells of Pts. In CEA specimens, Compact disc66b+ cells localized to areas with substantial plaque formation near neovessels. Pts with smooth and blend plaques, as described by computed tomography, didn’t differ in cPMN or pPMN IL-8, VEGF or elastase mRNA, or in intraplaque CD66b+ cell density. However, HST-1 Pts with soft plaques had higher white blood cell count because of increased PMN. Conclusions In Pts with carotid plaques, both circulating and intraplaque PMN produce IL-8, VEGF and elastase, which are necessary for plaque development and progression. These findings suggest mechanistic explanations towards the reported correlation between PMN count and cardiovascular mortality in carotid ATH. Introduction Atherosclerosis (ATH) is from the accumulation of cholesterol deposits in subendothelial macrophage-derived foam cells and buy 344458-19-1 by subsequent adherence and entry of leukocytes in to the arterial wall, migration of smooth muscle cells in to the intima, activation and aggregation of platelets, endothelial dysfunction, as well as the production of inflammatory cytokines [1C3]. Among immune cells infiltrating atherosclerotic buy 344458-19-1 lesions, polymorphonuclear neutrophil leukocytes (PMN) have already been only recently defined as key contributors towards the pathogenesis and progression of ATH [4C6], despite their involvement in the chronic, low-grade inflammation occurring early in subjects at risky to develop coronary disease (CVD) was extensively characterized [7C10]. PMN infiltration occurs in chronically inflamed arteries, and animal models demonstrates circulating PMN are recruited into atherosclerotic lesions, while depletion of PMN reduces plaque formation . PMN products like the human neutrophil peptide have already been proposed as biological markers and potential therapeutic targets in cardiovascular diseases an elevated quantity of circulating neutrophils is a well-known risk indicator of future cardiovascular outcomes [5,13]. Atherectomy specimens with plaque erosion or rupture show clear PMN infiltration and patients with unstable angina pectoris have increased PMN within pathological lesions regarding patients with stable disease . Several possible mechanisms of PMN-driven atherogenesis and plaque destabilization have already been proposed [15,16] like the production of mediators which donate to ATH. PMN will be the exclusive producers from the enzyme elastase , which donate to matrix degradation and weakening from the vessel wall connected with complications like aneurysm formation and plaque rupture . PMN also produce high levels of interleukin (IL)-8, a potent proinflammatory CXC-chemokine that promote PMN chemotaxis and degranulation . High plasma degrees of IL-8 are connected with an elevated risk to build up CVD , and we’ve shown that circulating PMN from subjects at high cardiovascular risk exhibit increased production of IL-8 [7,9] while PMN from patients with peripheral arterial buy 344458-19-1 disease undergoing femoral endarterectomy produce only low levels of IL-8 . Recently IL-8 continues to be characterized in cancer as an integral proangiogenic factor and extensive evidence supports the role of PMN in tumor angiogenesis through the production of IL-8 and of other proangiogenic factors such as for example vascular endothelial growth factor (VEGF) [23,24]. Regardless of the need for angiogenesis for atherogenesis and plaque development and destabilization [25,26], only fragmentary evidence up to now exist about the production of IL-8 and VEGF by PMN in ATH. In today’s study, production of IL-8, VEGF and elastase, by PMN was investigated in patients with carotid stenosis undergoing carotid endarterectomy (CEA). PMN were isolated from both peripheral venous blood and surgically removed plaques, and their functional profiles were characterized. We aimed to compare the functional profile of PMN from patients (Pts) with ATH with cells from healthy subjects (HS) also buy 344458-19-1 to assess, in Pts, any possible differences between intraplaque PMN (pPMN) and cPMN. Furthermore, any possible correlations between PMN and plaque characteristics were evaluated. Finally, inside a subgroup of surgical specimens,. The and genes both encode protein that repress mechanistic focus on of rapamycin (mTOR) signaling. size, dendrite duration and actions potential properties. Nevertheless, the consequences of Pten and Tsc1 reduction on synaptic transmitting were different. Lack of Pten result in a rise in both excitatory and inhibitory neurotransmission, while lack Rabbit Polyclonal to NRIP2 of Tsc1 didn’t have an effect on excitatory neurotransmission and decreased inhibitory transmitting by lowering mIPSC amplitude. Although the increased loss of Pten or Tsc1 both elevated downstream mTORC1 signaling, phosphorylation of Akt was elevated in Pten-ko and reduced in Tsc1-ko neurons, possibly accounting for the various results on synaptic transmitting. Regardless of the different results on the synaptic level, our data claim that lack of Pten or Tsc1 may both result in a rise in the proportion of excitation to inhibition on the network level, an impact that is suggested to underlie both epilepsy and autism. or genes. The proteins products of the genes are very similar in lots of ways: (1) these are both repressors of mTOR signaling and within their lack the mTORC1 complicated is normally hyperactive, (2) their reduction in neurons can result in hyperexcitable network activity, and (3) rapamycin, an inhibitor of mTOR, blocks the mobile and behavioral implications of their reduction in animal versions, and potentially human beings aswell (Krueger et al., 2013). This proof predicts that the consequences of Pten or Tsc1/2 disruption on neuronal type and function could be similar. On the molecular level, research from fungus and in mammalian cell lines, mainly in the framework of cancer analysis, have provided an abundance of details on the essential organization from the mTOR pathway as well as the tasks that Pten and 920113-03-7 Tsc1 play. From these research it is very clear that among the main inputs to mTOR activity can be insulin and development element receptor signaling (Harris and Lawrence, 2003; Manning and Cantley, 2003; Avruch et al., 2006; Howell and Manning, 2011). Receptor activation, through some intracellular occasions making use of phosphoinositide-3 kinase (PI3K), qualified prospects to improved PIP3 amounts and membrane localization of Akt, circumstances that mementos its phosphorylation. Pten represses this pathway by catalyzing the transformation of PIP3 to PIP2, which eventually leads to decreased 920113-03-7 Akt phosphorylation and decreased activity of Akt toward its substrates. One essential substrate of Akt can be Tsc2, which complexes with Tsc1 to operate like a GTPase activating proteins that, via Rheb, inhibits mTORC1. Lack of either Pten or Tsc1 are both considered to disrupt these molecular occasions and result in extreme activity of mTORC1, nevertheless, the unique placement of each proteins in the pathway as well as the potential of every to do something on targets apart from their canonical mTOR-related types raise the probability that the practical effects of their reduction may possibly not be overlapping. In neurons, earlier research have consistently demonstrated that lack of either Pten or Tsc1/2 raises neuronal cell body size (Backman et al., 2001; Kwon et al., 2001; Tavazoie et al., 2005; Meikle et al., 2007; Feliciano et al., 2011). Reduction or reduced amount of Pten also raises development of axons, dendrites, and backbone/synapse development (Jaworski et al., 2005; Kwon et al., 2006; Fraser et al., 2008). While lack of Tsc1/2 offers been shown to improve axon development and dendritic difficulty (Meikle et al., 2007; Choi et al., 2008; Feliciano et al., 2011, 2012), the reported results 920113-03-7 on backbone and synapse quantity are adjustable (Tavazoie et al., 2005; Meikle et al., 2007; Bateup et al., 2011; Tsai et al., 2012). From a physiological standpoint, lack of Pten offers been shown to improve excitatory synaptic transmitting due to raises in the mEPSC amplitude (Luikart et al., 2011; Weston et al., 2012; Xiong et al., 2012). While lack of Tsc1 in addition has been associated with improved excitation, the root mechanism isn’t obvious (Tavazoie et al., 2005; Wang et al., 2007; Bateup et al., 2011, 2013). Variations in neuron type, period, and degree of gene deletion and supplementary ramifications of seizures may all possess added to these adjustable results. 920113-03-7 To be able to check the degree to which lack of Pten or Tsc1 offers overlapping results on neuronal type and function, we performed a primary 920113-03-7 comparison from the mobile neurophysiology and morphology of autaptic hippocampal neurons where or was genetically disrupted. We discovered that lack of Pten or Tsc1 triggered similar. During the last 30?years, the focus on the function of arterial rigidity in the introduction of cardiovascular illnesses steadily accrued. Arterial stiffening leads to a widening from the arterial pulse pressure and regional boosts in shear tension, which is connected with endothelial dysfunction and vascular disease [2, 3]. Arterial rigidity increases with age group, cardiometabolic abnormalities, and elevated sodium intake, which are connected with center failing . Furthermore, arterial rigidity by itself is certainly associated with still left ventricular diastolic dysfunction [5C7]. The explanation for this relationship appears to be the fact an upsurge in left-ventricular end-systolic and arterial elastance takes place with ageing and could bring about ventricular-vascular stiffening resulting in diastolic dysfunction . Arterial stiffening continues to be identified as a significant predictor of cardiovascular occasions and it is more and more used being a parameter in the scientific assessment of sufferers. Endpoints connected with arterial rigidity consist of myocardial infarction, center failure, heart stroke, dementia, renal disease and mortality . Hypertension and still left ventricular hypertrophy will be the common risk elements of diastolic dysfunction by adding to ventricular rigidity (elastance). Both still left ventricular hypertrophy and diastolic dysfunction have already been associated with cardiovascular morbidity and mortality, regardless of blood circulation pressure [10, 11]. Longstanding hypertension qualified prospects to both ventricular and vascular stiffening and can contribute to raised systolic filling up pressure level of sensitivity to modified chamber filling up. Diastolic dysfunction continues to be acknowledged to become one the unavoidable outcomes in the moderate to long-term. In this problem of holland Heart Journal, Hu et al. record on the partnership between arterial tightness and remaining ventricular dysfunction . The writers conclude that remaining ventricular diastolic dysfunction includes a immediate romantic relationship to arterial stiffening, self-employed of cardiovascular risk elements. Furthermore they confirm the connection between many well-known baseline features and both diastolic dysfunction and arterial tightness. The writers conclude that the severe nature of remaining ventricular diastolic dysfunction correlates with the severe nature of arterial tightness. The first remarkable observation when reading the manuscript may be the design of the analysis. As the abstract shows that the populace comprises a cohort of (consecutive?) individuals older than 45 hospitalised between 2010 and 2011, the techniques section reviews that the prospective population was predicated on 4985 Chinese language inhabitants which 1,080 experienced from hypertension and 198 (i.e. 18?%) received no antihypertensive medicine. Aside from the discrepancy with the info in the abstract, the explanation behind the chosen study population continues to be unclear. As the writers clearly condition in the debate paragraph, there’s a clear aftereffect of Enzastaurin generally diuretics, ACE inhibitors and angiotension-II receptor antagonists on still left ventricular filling stresses. Besides the reality that it’s doubtful why these sufferers with a indicate systolic blood circulation pressure of 145?mmHg didn’t receive antihypertensive medications, having less pharmaceutical therapy in these sufferers may limit the generalisability from the findings. The idea of a primary and independent relation between arterial stiffness and diastolic dysfunction is interesting and continues to be topic of question in a number of previous studies . Nevertheless, this automatically will take us to the biggest question mark relating to the present research. The writers performed univariate and multivariable analyses to measure the association between diastolic dysfunction (E/E) and arterial rigidity (parameter ) and conclude that there surely is a relationship between arterial rigidity and age, smoking cigarettes and central blood circulation pressure. Nevertheless, in the univariate analyses age group didn’t emerge to become connected with either diastolic function or arterial rigidity. Despite this extraordinary insufficient association, age do emerge being a predictor for both result guidelines in the multivariable model. A lot more remarkable would be that the writers performed co-linearity tests to exclude the opportunity of discussion between multiple guidelines in the multivariable model. Obviously, no discussion was discovered between age group and both diastolic dysfunction and arterial tightness, this as opposed to what you might anticipate. The age-specific romantic relationship of arterial tightness with left-ventricular geometry and function in individuals with hypertension continues to be widely researched and verified [13, 14]. Sadly, having less age-specific analyses precludes any conclusions concerning this relationship in today’s study. Further exploring the inclusion requirements of the analysis reveals that individuals, or inhabitants, with regional wall structure movement abnormalities or decreased ejection small fraction were excluded. It really is unclear why the researchers excluded these individuals since in the dialogue they say that subclinical atherosclerosis can be connected with myocardial dysfunction, which alterations in remaining ventricular structure donate to this dysfunction. This summary seems relatively far-fetched because the authors didn’t report on the current presence of atherosclerosis. The last mentioned even though common carotid artery intima mass media thickness using high-resolution B-mode ultrasound imaging was documented. Correlating the leads to the amount of common carotid intima mass media thickness could have been interesting. The authors declare that stiffening in large elastic arteries is connected with multiple cardiovascular risk factors, including hypertension, dyslipidaemia, obesity, smoking, diabetes, and ageing, which stimulate the introduction of atherosclerosis. Additionally, rigidity parameter beta was utilized being a measure for arterial rigidity. Although several prior studies have utilized this parameter, many issues ought to be recognized. Clearly, one of the most optimum spot to measure arterial rigidity will be the aorta provided its professional contribution towards the arterial buffering function as well as the 3rd party predictive worth of aortic pulse influx velocity to result in a number of populations [15C19]. Measuring arterial rigidity along the aorto-iliac pathway can be hypothesised to result in the medically most relevant guidelines, because the aorta as well as the 1st branches will be the 1st hurdles to become tackled from the remaining ventricle and therefore are in charge of a lot of the pathophysiological LY9 ramifications of arterial tightness . For the reason that of this cause that, relating to a Western Society professional consensus record, carotid-femoral pulse influx velocity happens to be the gold regular for calculating arterial tightness . The usage of tightness parameter beta in today’s format is fixed to dimension of the normal carotid artery. The biggest pitfall of the technique, however, may be the truth that in individuals with diabetes and/or hypertension the aorta stiffens a lot more than the carotid artery with age group and additional cardiovascular risk elements . Whether tightness parameter beta therefore adequately reflects the real intensity of arterial tightness remains questionable. A variety of parameters estimating the amount of arterial stiffness have already been proposed. Certainly pulse wave speed and enhancement index are separately connected with systolic and diastolic dysfunction; nevertheless, the potentially least complicated parameter to make use of can be pulse pressure, which includes also been proven to predict still left ventricular hypertrophy and cardiovascular occasions [4, 23]. As cardiac result falls, neurohumoral activation qualified prospects to vasoconstriction using the intention to keep mean arterial pressure. In the long run increased vascular soft muscle mass, shade, and fibrosis, leading to increased rigidity and pulse pressure will be the unavoidable consequences. A primary romantic relationship between neurohumoral activation and elevated carotid stiffness continues to be seen in center failure . However the influence of pulse strain on the outcomes in today’s study continues to be unsolved. In conclusion, Hu et al. confirm the partnership between arterial rigidity and diastolic dysfunction . Whether arterial rigidity really precedes and predicts the introduction of remaining ventricular dysfunction or whether both guidelines are simply the consequence of the ageing from the cardiovascular system continues to be the question. Funding None. Discord of interests None declared. Footnotes “Editorial to THE PARTNERSHIP Between Arterial Wall structure Stiffness and Still left Ventricular Dysfunction by Hu et al. Neth Center Journal Feb 2013. is connected with remaining ventricular diastolic dysfunction [5C7]. The explanation for this connection appears to be the fact an upsurge in left-ventricular end-systolic and arterial elastance happens with ageing and could Enzastaurin bring about ventricular-vascular stiffening resulting in diastolic dysfunction . Arterial stiffening continues to be identified as a significant predictor of cardiovascular occasions and is progressively used like a parameter in the medical assessment of individuals. Endpoints connected with arterial tightness consist of myocardial infarction, center failure, heart stroke, dementia, renal disease and mortality . Hypertension and still left ventricular hypertrophy will be the common risk elements of diastolic dysfunction by adding to ventricular rigidity (elastance). Both still left ventricular hypertrophy and diastolic dysfunction have already been associated with cardiovascular morbidity and mortality, regardless of blood circulation pressure [10, 11]. Longstanding hypertension network marketing leads to both ventricular and vascular stiffening and can contribute to raised systolic filling up pressure awareness to changed chamber filling up. Diastolic dysfunction continues to be acknowledged to become one the unavoidable implications in the moderate to long-term. In this matter of holland Center Journal, Hu et al. statement on the partnership between arterial tightness and remaining ventricular dysfunction . The writers conclude that remaining ventricular diastolic dysfunction includes a immediate romantic relationship to arterial stiffening, self-employed of cardiovascular risk elements. Furthermore they confirm the connection between many well-known baseline features and both diastolic dysfunction and arterial tightness. The writers conclude that the severe nature of remaining ventricular diastolic dysfunction correlates with the severe nature of arterial tightness. The first amazing observation when reading the manuscript may be the style of the analysis. As the abstract shows that the populace comprises a cohort of (consecutive?) individuals older than 45 hospitalised between 2010 and 2011, the techniques section reviews that the mark population was predicated on 4985 Chinese language inhabitants which 1,080 experienced from hypertension and 198 (i.e. 18?%) received no antihypertensive medicine. Aside from the discrepancy with the info in the abstract, the explanation behind the chosen study population continues to be unclear. As the writers clearly condition in the conversation paragraph, there’s a clear aftereffect of primarily diuretics, ACE inhibitors and angiotension-II receptor antagonists on remaining ventricular filling stresses. Besides the truth that it’s doubtful why these individuals with a imply systolic blood circulation pressure of 145?mmHg didn’t receive antihypertensive medicines, having less pharmaceutical therapy in these individuals may limit the generalisability from the findings. The idea of a primary and independent connection between arterial rigidity and diastolic dysfunction is normally interesting and continues to be topic of issue in several prior studies . Nevertheless, this automatically will take us to the Enzastaurin Enzastaurin biggest question mark relating to the present research. The writers performed univariate and multivariable analyses to measure the association between diastolic dysfunction (E/E) and arterial rigidity (parameter ) and conclude that there surely is a relationship between arterial rigidity and age, smoking cigarettes and central blood circulation pressure. Nevertheless, in the univariate analyses age group didn’t emerge to become connected with either diastolic function or arterial rigidity. Despite this extraordinary insufficient association, age do emerge like a predictor for both end result guidelines in the multivariable model. A lot more remarkable would be that the writers performed co-linearity screening to exclude the opportunity of connection between multiple guidelines in the multivariable model. Obviously, no connection was discovered between age group and both diastolic dysfunction and arterial tightness, this as opposed to what you might anticipate. The age-specific romantic relationship of arterial tightness with Enzastaurin left-ventricular geometry and function in individuals with hypertension continues to be widely analyzed and verified [13, 14]. However, having less age-specific analyses precludes. Background In Traditional Chinese language Medication (TCM) theory, functional dyspepsia (FD) could be split into different syndromes according to different scientific symptoms and signals, and the most frequent you are spleen-deficiency and qi-stagnation symptoms that may be treated by Chinese language traditional patent medicine —- two forms of Zhizhu supplements, between that your major difference in ingredients is that certain contains immature orange fruit of Citrus aurantium L. in sufferers with FD of spleen-deficiency and qi-stagnation symptoms at 3 clinics in Beijing between June 2003 and could 2005. Participants had been arbitrarily allocated into two groupings (IFCA group and IFCS group) within a 1:1 proportion, and respectively got among the two forms of Zhizhu supplements orally, 6 g every time, 3 times per day, for four weeks. Statistical evaluation was performed with usage of an organization sequential technique, the triangular check (TT). Results A complete of 163 sufferers had been randomized, and 3 sufferers had been excluded from evaluation due to early dropouts, departing 160 sufferers (IFCA group: n = 82; IFCS group: n = 78) for statistical evaluation. Three interim analyses had been completed after 62, 116, and 160 sufferers had finished their 4-week treatment, respectively. At the 3rd interim evaluation, the sample route crossed top of the boundary as well as the trial was ceased, the cure-markedly effective prices had been 45% for IFCS group and 67% for IFCA group, respectively, the one-sided em p /em -worth was 0.0036, the median unbiased estimation of the chances proportion (OR) for the advantage of IFCA in accordance with IFCS was 2.91 with 95%CI: 1.40 to 6.06. No undesirable events were seen in the two groupings. Conclusions Zhizhu supplements formulated with IFCA was more advanced than Zhizhu supplements formulated with IFCS in the treating FD of spleen-deficiency and qi-stagnation symptoms. The use of group sequential evaluation in scientific studies of TCM may give some economic and moral benefits. Trial Enrollment Chinese language Scientific Trial Registry (ChiCTR): Cyproterone acetate ChiCTR-TRC-00000485 Background Based on the proposition of a global committee conference in Rome in 1991, the word “dyspepsia” identifies pain or soreness centered within the higher abdominal?, while soreness identifies a subjective harmful (or aversive) feeling, such as for example early satiety, fullness, bloating and nausea. In Rome I and Rome II reviews?[2,3], functional dyspepsia (FD) is thought as a persistent or repeated dyspepsia for in least 12 weeks within the preceding a year, when there is zero evidence for organic disease (including in higher endoscopy) which Cyproterone acetate could cause the outward symptoms. An epidemiological study of traditional western countries showed the fact that prevalence of FD ranged from 11.5% to 14.7%?. Additionally it is a typical scientific condition in China, as well as the report in the occurrence of FD in people of Tianjin, China, uncovered that the percentage of sufferers with FD reached 23.29% of the full total population?. In traditional western medicine, the treating FD remains a significant unsolved issue in gastroenterology, which is really a discouraging and unsatisfactory circumstance for treating doctors. In traditional Chinese language medication (TCM), FD is known as nearly equal to the TCM term “stuffiness and fullness” , that is split into different syndromes regarding to different scientific symptoms and symptoms. The essential syndromes consist of liver-stomach disharmony symptoms (qi-stagnation symptoms), liquid and meals retention symptoms, dampness-heat of spleen and tummy symptoms, spleen-stomach weakness symptoms (spleen-deficiency symptoms), and frosty Cyproterone acetate and high temperature in complexity symptoms. It ought to be observed that in scientific practice, qi-stagnation symptoms and spleen-deficiency symptoms often get together, that is referred to as the spleen-deficiency and qi-stagnation symptoms and can end up being Cyproterone acetate treated by Chinese language traditional patent medication —- two forms of Zhizhu supplements?. Both of these are produced from Rhizoma Atractylodis Macrocephalae (stir-baked) and Fructus Aurantii Immaturus (immature orange fruits, Rabbit Polyclonal to EIF3D stir-baked), while their principal difference in substances is that certain includes immature orange fruits of Citrus aurantium L.(IFCA) as well as the additional contains that of Citrus sinensis Osbeck (IFCS). In medical practice, both Zhizhu supplements have been regarded as effective in the treating practical dyspepsia (FD) of spleen-deficiency and qi-stagnation symptoms. The trial’s objective was to evaluate the effectiveness of two forms of Zhizhu supplements on symptom adjustments in individuals with FD of spleen-deficiency and qi-stagnation symptoms. Methods Trial style A randomized, group sequential, double-blinded, multicenter trial was carried out in individuals with FD of spleen-deficiency and qi-stagnation symptoms at 3 private hospitals in Beijing between June 2003 and could 2005. Participants In line with the Rome-II requirements as well as the Guiding theory for medical research on fresh medicines of traditional Chinese language medicine (trial execution)?, individuals with FD of spleen-deficiency and qi-stagnation symptoms were signed up for the analysis. The spleen-deficiency and qi-stagnation. Conflicting effects identifying the partnership between benzodiazepine medication use and tumor risk. of duration incremental upsurge in benzodiazepine medication use was connected with a 17%, 4%, 16% and 5% in tumor risk increment. Taking into consideration these promising outcomes, raising benzodiazepine using may be dangerous for wellness. 0.001) (Desk ?(Desk3).3). Furthermore, benzodiazepines medication use is considerably associated with tumor risk in Caucasia (RR:1.21; 95% CI, 1.05C1.39; 0.001) (Desk ?(Desk3)3) and Asia (RR:1.36; 95% CI, 1.16C1.59; 0.001) (Desk ?(Desk3).3). Additionally, benzodiazepines medication use is considerably associated with tumor risk in feminine (RR:1.14; 95% CI, 1.04C1.24; = 0.004) (Desk ?(Desk3)3) however, not in male (RR:1.12; 95% CI, 0.96C1.30; = 0.154) (Desk ?(Desk3).3). Which may be because there is not more than enough data in man. Desk 3 Stratified analyses of comparative risk SQ109 of tumor for check 0.001) (Desk ?(Desk4).4). Furthermore, benzodiazepines medication use is considerably associated with breasts cancers risk in Caucasia (RR:1.17; SQ109 95% CI, 1.08C1.26; 0.001) (Desk ?(Desk4)4) and Asia (RR:1.09; 95% CI, 1.03C1.16; 0.001) (Desk ?(Desk4).4). Eight 3rd party reviews from six research looked into the association between benzodiazepines medication make use of and ovarian tumor risk. Weighed against no benzodiazepines medication use, benzodiazepines medication use is considerably associated with an increased threat of ovarian malignancy (RR:1.17; 95% CI, 1.09C1.25; 0.001) (Desk ?(Desk4).4). Furthermore, benzodiazepines medication use is considerably connected with ovarian malignancy risk in Caucasia (RR:1.22; 95% CI, 1.15C1.30; 0.001) (Desk ?(Desk4)4) and Asia (RR:1.11; 95% CI, 1.05C1.17; 0.001) (Desk ?(Desk4).4). Additionally, Weighed against no benzodiazepines medication use, benzodiazepines medication use is considerably associated with a greater risk of cancer of the colon (RR:1.07; 95% CI, 1.02C1.13; 0.001) (Desk ?(Desk4),4), renal malignancy (RR:1.31; 95% CI, 1.15C1.49; 0.001) (Desk ?(Desk4),4), malignant melanoma (RR:1.10; 95% CI, 1.03C1.17; 0.001) (Desk ?(Desk4),4), mind malignancy (RR:2.06; 95% CI, 1.76C2.43; 0.001) (Desk ?(Desk4),4), esophagus malignancy (RR:1.55; 95% CI, 1.30C1.85; 0.001) (Desk ?(Desk4),4), prostate malignancy (RR:1.26; 95% CI, 1.16C1.37; 0.001) (Desk ?(Desk4),4), liver organ malignancy (RR:1.22; 95% CI, 1.13C1.31; 0.001) (Desk ?(Desk4),4), belly malignancy (RR:1.17; 95% CI, 1.03C1.32; 0.001) (Desk ?(Desk4),4), pancreatic malignancy (RR:1.39; 95% CI, 1.17C1.64; 0.001) (Desk ?(Desk4),4), lung malignancy (RR:1.20; 95% CI, 1.12C1.28; 0.001) (Desk ?(Desk44). Desk 4 Stratified analyses of comparative threat of different malignancy for check 0.001), suggesting curvature in the SQ109 partnership, increasing per 500 mg/12 months of benzodiazepine medication use was connected with a 17% increment of malignancy risk, the overview relative threat of malignancy risk for an per 500 mg/12 months of benzodiazepine medication use was 1.17 (95% CI: 1.02C1.35, = 0.022) (Physique ?(Figure2).2). Furthermore, increasing benzodiazepine medication make use of (per 3 prescriptions increment) was connected with a 16% increment in malignancy risk, the overview relative threat of malignancy risk for an per 3 prescriptions of benzodiazepine medication make use of was 1.16 (95% CI: 1.11C1.22, 0.001) (Physique ?(Figure2).2). Furthermore, raising per 3 12 months of period of benzodiazepine medication use was connected with a 5% increment of FABP4 malignancy risk, the overview relative threat of malignancy risk for an per 3 12 months of period of benzodiazepine medication make use of was 1.05 (95% CI: 1.02C1.09, = 0.042) (Physique ?(Figure2).2). Additionally, raising per 5 12 months of your time since 1st benzodiazepine medication use was connected with a 4% increment of malignancy risk, the overview relative threat of malignancy risk for an per 5 12 months of your time since 1st benzodiazepine medication make use of was 1.04 (95% CI: 1.01C1.07, = 0.003) (Physique ?(Figure22). Open up in another window Physique 2 Dose-response romantic relationship between benzodiazepine medication. The purpose of this study was to judge associations between coronary disease (CVD) risk factors as well as the occurrence of venous thromboembolism (VTE) in patients with lung cancer that may help estimate somebody’s risk for VTE. tumor stage versions. Leukocytosis was linearly connected with hypertension and VTE (for tendency?=?0.006), as well as the ORs for VTE increased with leukocytosis (all for tendency 0.05). To conclude, hypertension improved the chance of VTE in individuals with recently diagnosed lung tumor, which might be mediated by the current presence of swelling. Venous thromboembolism (VTE) is among the highest problems in individuals with solid tumor ,specifically in lung tumor1,2,3. Basic risk elements for cancer-associated VTE consist of aging, poor efficiency status, prior background of VTE, histology of tumor, origin of tumor, chemotherapy, medical procedures, and additional treatment-related elements1,4,5,6,7. Although the chance elements potentially in charge of this disorder are identifiable generally in most individuals, cancer-associated VTE continues to be unexplained in a few individuals. Coronary disease (CVD) risk elements, such as smoking cigarettes, weight problems, hypertension, dyslipidemia, and diabetes, frequently coexist with tumor. The chance of arterial thrombosis in individuals with main CVD risk elements is most probably mediated by the current presence of an inflammatory condition KSR2 antibody and hypercoagulability8. Both improved swelling and coagulation may predispose these individuals to build up VTE occasions9. Furthermore, metabolic symptoms increases the threat of developing multiple types of tumor and VTE10,11,12,13. We hypothesized that tumor individuals with CVD risk elements could be at improved threat of VTE. To check this hypothesis, we examined associations between main CVD risk elements and event of VTE in individuals with recently diagnosed lung tumor. Results Patient features A complete of 691 unselected individuals with recently diagnosed lung tumor were signed up for this research. Sixteen individuals had been excluded because that they had a brief history of deep vein thrombosis (DVT) or pulmonary embolism (PE) a lot more than 90 days before recruitment. Skepinone-L Another forty-three individuals had been excluded because these were consistently taking anticoagulants. In the long run, 632 eligible individuals were contained in our research (Fig. 1). Open up in another window Shape 1 Study movement diagram.Abbreviations: VTE?=?venous thromboembolism; CVD?=?coronary disease. The 632 included lung tumor individuals got a median age group of 63.5 years, and 71.7% from the individuals were man. The baseline demographic and medical characteristics from the looked into research population are detailed in Desk 1. To investigate non-small cell lung tumor and little cell lung tumor collectively, the tumors had been histologically classified as adenocarcinoma or non-adenocarcinoma (all lung malignancies apart from adenocarcinoma), as well as the tumor stage was classified as localized stage (limited to ipsilateral hemithorax) or faraway metastasis. The analysis population contains individuals with adenocarcinoma (n?=?295) and individuals with non-adenocarcinoma (n?=?337). Distant metastases had been within 276 individuals (43.7%). Desk 1 Baseline demographic and medical characteristics of the full total research human population (n?=?632). ideals significantly less than 0.05 are shown in the desk. Abbreviations: VTE?=?venous thromboembolism; OR?=?Chances Percentage; WBC?=?white blood cell. Desk 4 Factors connected with improved VTE risk in the multivariate logistic regression model (model 2) among recently diagnosed lung tumor individuals with different tumor phases *. values significantly less than 0.05 are shown in the desk. Abbreviations: VTE?=?venous thromboembolism; OR?=?Chances Percentage; WBC?=?white blood Skepinone-L cell. Finally, we examined the organizations of leukocytosis and hypertension with VTE. The individuals were Skepinone-L categorized as four subgroups (no hypertension no VTE, just hypertension, just VTE, or both hypertension and VTE) based on the inflammation fill. The pace of leukocytosis was considerably different in the four subgroups (for tendency?=?0.006). The ORs for VTE risk improved among the four subgroups (all for tendency? ?0.05; Desk 5). Desk 5 Leukocytosis and ORs for VTE among recently diagnosed lung tumor individuals. for. Pediatric high-grade glioma (HGG) is certainly a damaging disease having a two-year survival of significantly less than 20%1. mutations are really uncommon in adult HGGs 3. HGGs arising in babies more youthful than three years of age possess an improved prognosis, and a lesser regularity of mutations, recommending that there could be age-dependent subgroups of HGG also inside the pediatric inhabitants2. Hence, the selective stresses generating gliomagenesis in kids vary with age group and anatomical site. To even more comprehensively understand the pathways generating youth glioma, we examined the genomic surroundings of HGGs from 118 pediatric sufferers (127 tumors, 108 matched up to germline DNA) comprising 57 DIPGs and 70 non-brainstem HGGs (NBS-HGG) by entire genome (WGS) (n= 42), entire exome (n= 80) or transcriptome sequencing (n= 75) PNU 282987 (Supplementary Desks 1-9). A complete of 39,590 series mutations, including one nucleotide variants (SNVs) and little insertions or deletions, and 2,039 structural variants (SVs) were discovered by WGS while yet another 2,600 series mutations and 138 SVs had been discovered by exome sequencing and transcriptome sequencing, respectively. General, the cohort demonstrated a median history mutation price of 9E-07 and a median of 22 SVs PNU 282987 per genome (Supplementary Fig. 1). All SNVs and SVs within WGS were confirmed experimentally by indie sequencing strategies (Online Strategies). Among repeated mutations in pediatric HGG, the most regularly mutated gene not really previously discovered in cancers was (also called mutations were discovered solely in DIPGs (32%), and had been significantly connected with youthful age, longer success, and the current presence of pK27M (p 0.0000001), or or mutations (p 0.005)(Fig. 1 and ?and2,2, Supplementary Fig. 3, Supplementary Desks 4 PNU 282987 and 5). Four of the PNU 282987 somatic mutations had been exactly like germline mutations previously discovered in the autosomal prominent symptoms fibrodysplasia ossificans progressiva (FOP), where aberrant mobile differentiation drives intensifying heterotopic ossifications18,19. All residues influenced by mutation in DIPG cluster around either the inhibitory glycine/serine wealthy (G/S) area or the ATP binding pocket from the kinase area, and will be expected to change the kinase to a dynamic conformation (Body 2 and Supplementary Fig. 3c)20. Certainly, mutations of the residues induced a weakened gain of function20,21. A prior study showed the fact that R206H mutation triggered a ventralized phenotype in zebrafish embryos, TM4SF19 an signal of BMP pathway activation22. We examined every one of the mutations within DIPG employing this assay. Zebrafish embryos injected with mutants, proven to be able of intensity, exhibited varying levels of ventralization with incomplete to complete lack of mind and dorsal buildings (Fig. 2b,c, Supplementary Fig. 3d,e). A moderate dosage of LDN-193189 (LDN), an extremely selective antagonist from the BMP pathway22,23, partly reversed the ventralization results induced by mutants as is seen by the recovery of dorsal mind buildings for R258G, G328E, G328W, R206H as well as the decreased intensity of ventralization for G356D and G328V (Fig. 2c). Appearance of mutants in mouse principal astrocyte cultures triggered increased degrees of phospho-SMAD1/5, a downstream sign of energetic BMP signaling, with differing magnitude (Fig. 2d). LDN also successfully obstructed signaling to phospho-SMAD1/5 downstream from the mutant ACVR1 in principal astrocytes (Supplementary Fig. 3f). Open up in another home window Fig. 1 Recurrent hereditary modifications in pediatric high-grade gliomaGenetic modifications discovered in 19 genes, including (H3.3) and (H3.1) mutations are grouped together in to the category H3. Structural variations regarding G1 checkpoint complicated are grouped jointly as or mutations in DIPG activate BMP signalinga. Missense substitutions in DIPG had been clustered. can be an intestinal mouse pathogen trusted being a model to review the mucosal reaction to infection. of fatal diarrheal disease during an infection through encodes an associate from the R-spondin category of secreted protein, which have lately surfaced as potent enhancers from the canonical Wnt signaling pathway4. This pathway has a crucial function in regulating epithelial cell destiny and perseverance, and may be the generating drive behind the proliferation of intestinal epithelial precursors5. is normally robustly induced during an infection in prone mouse strains, resulting in pathological activation of Wnt signaling, era of a badly differentiated colonic epithelium, and pet loss of life3,6C8. On the other hand, resistant mice that usually do not express pursuing an infection still develop colonic epithelial hyperplasia on the peak of an infection but suffer milder, self-limiting disease without suffering from a lack of intestinal function3. In order to avoid any confounding hereditary and phenotypic distinctions between divergent inbred strains, we created a congenic mouse stress that is on the 100 % pure C3H/HeOuJ (henceforth known as C3Ou) prone background but posesses portion of chromosome 15 encompassing and its own regulatory area from resistant C57BL/6 mice6. These resistant congenic mice display complete survival pursuing an infection compared to prone C3Ou mice which suffer 100% mortality. Furthermore, we previously showed that bacterial tons and an infection kinetics are similar in prone C3Ou and resistant congenic mice6, a sensation that’s not observed when you compare different prone and resistant inbred strains9. This means that that will not have an effect on bacterial colonization or replication but instead the ability from the web host to determine disease tolerance in the current presence of pathogenic bacteria within the intestine. Disease tolerance Alarelin Acetate is normally a bunch defence technique that decreases the unwanted effects of an infection over the web host without impacting pathogen burden10. Our exclusive parental and congenic strains, differing just in their appearance of during an infection, therefore give a even more accurate experimental model program to review the biological ramifications of on disease tolerance when compared with those predicated on genetically divergent inbred mouse strains. In today’s study, we utilized RNA sequencing technology to characterize the global distributed response to an infection in both BMS-708163 prone and resistant congenic mice, also to define the entire an infection RNA-seq was performed over the Illumina HiSeq. 2000/2500 sequencer to explore the powerful and global transcriptome information of prone and resistant congenic mice colons which were either uninfected or contaminated with for 9 times, the latest period point where contaminated prone mice are regularly viable. In keeping with our prior work, we verified that bacterial tons were identical inside our prone and resistant congenic mice at 9 times post-infection (Supplementary Fig.?S1). We eventually performed primary component evaluation (PCA) to judge the amount of similarity within the gene appearance patterns of every sample. PCA uncovered three distinctive clusters: uninfected handles, contaminated prone mice, and contaminated resistant mice, indicating that examples are carefully grouped based on mouse stress and an infection status, which few transcriptomic distinctions are found between strains ahead of an infection (Fig.?1). Open up in another window Amount 1 Primary component evaluation (PCA) scatter story reveals split clustering predicated on mouse stress and an infection position. Colons from three mice per group had been gathered at 0 and 9 times post-infection for RNA sequencing and PCA of normalized web host gene counts for any examples was generated. We initial assessed the distributed global reaction to an infection both in strains by executing differential appearance analysis between your BMS-708163 uninfected and contaminated groupings using two well-established strategies: edgeR11 and DESeq212. Applying a threshold of log2 flip transformation?=?2 and adjusted an infection (Fig.?2B and C). Notably, the amount of considerably down-regulated genes was bigger than the amount of up-regulated genes: 744 genes down-regulated versus 438 genes up-regulated. Open up in another window Amount 2 Global summary of the distributed colonic reaction to an infection in prone and resistant congenic mice. (a) Venn diagram from the overlap between your group of differentially portrayed genes (DEGs) present by edgeR and DESeq2. DEGs are those exhibiting a log2 flip change greater than 2 BMS-708163 along with a p-value of significantly less than 0.05. (b) Heatmap of normalized browse counts from the.

2019-04-24T14:15:32Z

User Services AT Web Sites: User Agreement AT web sites should have a carefully worded user agreement that specifies the terms and conditions for use of the site. This agreement should be based on policies and should be reviewed by an attorney before posting. One attached example is from the Assistive Technology Exchange in New England/ Connecticut. Notice that it incorporates language disclaiming warranties and liabilities. NOTE: User agreements and disclaimers are often combined into a single document.

2019-04-25T16:37:13Z

We do not give up! We always give our very best. Every single step in our processes is evaluated not only by internal and external institution but before all, and best of all: by our customers themselves. Our exceptionally high return rate can be valued and taken as a sign of loyalty and interest of our clients.

2019-04-23T08:02:35Z

Welcome to the website of Apartamentos Ibiza, S.A.! We have all the essential ingredients that you need for a perfect family holiday, with really easy access to the beach. The Cala Llonga Playa Apartments, also known as the Ibiza Apartments, are particularly attractive for families. The location is wonderful, as they are situated in the heart of the village and just a short distance away from an irresistible expanse of golden beach.

2019-04-26T06:51:41Z

February 18th, 2014Today the ITW Africa team met with the Ugandan Minister of Health, Hon. Dr. Ruhakana Rugunda. In attendance were: the State Minister of Health for Primary Health Care, Hon. Sarah Opendi , the Commisioner of Clinical Services, Dr. Amandua Jacinto, and the Assistant Commisioner for Integrated Curative Services, Dr. Jackson Amone. We are pleased that the partnership between the Ministry of Health and Imaging the World is strengthening.

2019-04-20T04:57:31Z

According to a report published today by Reuters, if a couple of U.S. senators are correct, it would seem that Chinese telecom manufacturer ZTE has not learned its lesson. You might recall that back in April, the U.S. Commerce Department imposed an export ban on the company for failing to comply with punishments prescribed by the U.S. after ZTE illegally sold goods and services to North Korea and Iran. The transactions violated sanctions that were placed on those two countries by the U.S. The export ban crippled ZTE severely since it prevented the firm from obtaining hardware and software needed to build smartphones and other products. Despite the company's status on Capitol Hill as a threat to National Security, and President Donald Trump's campaign speeches attacking the Chinese for taking U.S. jobs, the president pushed the Commerce Department to work out a deal with ZTE because too many jobs in China had been lost due to the export ban. Eventually, a deal was reached. ZTE changed its board of directors, fired and replaced its executives, and paid the U.S. a whopping $1 billion fine. Additionally, the U.S. requested that ZTE place $400,000 in escrow for ten years to cover future violations. Keep that $400,000 in mind, because Senators Chris Van Hollen (D-MD) and Marco Rubio (R-FL) will send a letter to the White House today requesting that the U.S. secretaries of state, treasury and commerce investigate ZTE. The senators want to know whether the beleaguered firm, which is the fourth largest smartphone supplier in the U.S., illegally worked with individuals that are covered by government sanctions, unlawfully used U.S. parts and components, and helped the Venezuela government build a database that tracked its citizens and violated their rights. The senators are concerned that ZTE used Dell parts for the database. A document viewed by Reuters revealed that Dell storage units were used in equipment installed by ZTE for Venezuela's state owned telecom agency Cantv. Dell says it has no record of such a sale, and the U.S. State, Commerce and Treasury departments have not commented. Senators Van Hollen and Rubio want an investigation to determine "whether ZTE violated U.S. export controls with respect to the installation of data storage units built by Dell." They also want the administration to decide whether ZTE's work in helping Venezuela create its database violates the terms of the deal it made with the U.S. Commerce Department.

2019-04-21T06:14:48Z

Who is the highest earning Indian celebrity?. Forbes has released a Top 100 list recently of the highest earned Indian actor from India. So far Salman Khan tops the list. Who made the most from Kollywood?.

2019-04-20T07:21:12Z

Tranquility Beach Resort is a Citizenship by Investment Program-funded residential resort, being developed in Dominica by son-of-the-soil, Ian A. W. Edwards. The day I visited Syndicate was a happy one. The sun was out, there was modest cloud cover (perfect for capturing my timelapse sequences) and I most importantly, I stopped at the roadside bar called Everything For You Baby.

2019-04-21T23:16:29Z

¿ESTUDIAS Y BUSCAS EMPLEO DE MEDIO TIEMPO? NO LO PIENSES MÁS Y ÚNETE AL MEJOR CALL CENTER DE LA CIUDAD COMO EJECUTIVO EN PORTABILIDAD MOVISTAR!!! CONTAMOS CON CONTRATACIÓN INMEDITA Y CON CONTRATO INDEFINIDO!!! SI TIENES ENTRE 18 Y 35 AÑOS CUMPLIDOS NO LO PIENSES MÁS Y POSTULATE CONMIGO MARIEL CARRILLO!!! SI TIENES OCUPACIONES YA SE POR LA TARDE O POR LA MAÑANA, TENEMOS PARA TI HORARIOS FLEXIBLES!!! SÓLO TRABAJA 6 HORAS DE LUNES A SÁBADO!!! Empleo: ¡¡¡PORTABILIDAD MOVISTAR CONTRATACIÓN INMEDIATA!!!

2019-04-23T05:52:38Z

Proposed changes to the Entrepreneurs’ Relief are to be welcomed and will bring a boost to growth enterprises across the South, says HWB Director David Brookes. Following an announcement in the Spring Statement, HMRC is consulting on amending the rules around entrepreneurs’ tax relief. It follows a trend of entrepreneurs missing out on the tax relief if they issue new shares in a company, and in doing so, taking their total shareholding in the company below 5%. A shareholding of less than 5% does not qualify for the tax relief under the existing rules. Under the proposed changes, investors would be able to trigger the tax relief immediately prior to their issuing of new shares, and defer the tax until a later date, when they sell some of their own shares. Entrepreneurs’ Relief reduces the amount of Capital Gains Tax on a disposal of qualifying business assets on or after 6 April 2008, as long as you have met the qualifying conditions. David Brookes, who specialises in working with SMEs across Hampshire, Dorset and Wiltshire, said: “The present rules have been unchanged since 2011 and, while beneficial to many individuals, they often do not work in favour of business founders wanting to grow and issue more shares.

2019-04-21T12:25:15Z

From our Modern Legends range is this LFC Mens Grey Fowler Polo Shirt. Red Liverpool FC print across the centre. Robbie Fowler raised rubber to the right shoulder.

2019-04-21T20:19:48Z

Contemporary design wall art sculpture made from mdf with metal hooks. Size is a 16cm high and 30cm wide (6x12"), and this is a mdf cut out of the word 'home' that is set with attractive prints on each letter. It is also set with hooks that comes away from the wall 4cm so perfect for hanging your hat, scarf or light items on!!

2019-04-26T12:29:35Z

The American Board of Accredited Certifications (ABAC) has sent out a notice warning U.S. businesses about an India-based website promoting the infamous accreditation scheme of The International Accreditation Forum (IAF) found to be scamming U.S. businesses. An investigation showed the bogus “review” site known as Benchmark.org is another IAF propagandist machine engaging in fraudulent business practices. The India-run website is hoodwinking U.S. businesses by making them believe they must use a certification body accredited by the swindling operation International Accreditation Forum (IAF) for all ISO certifications. IAF is under investigation for anti-competitive business practices, fraud, crony capitalism, and the misuse of federal funds. ISOBench is operated by a known scammer hiding in India that goes by the alias “Mike Carlos”. He operates the ISOBenchmark/IAF scam out of a one bedroom apartment, pretending he’s some kind of “oversight” on the accreditation of ISO certifications. It is believed Mike Carlos works with known ISO scammer Christopher Mark Paris, owner of the bogus Florida operation Oxebridge Quality Resources. ISOBench is scamming businesses in similar fashion to Oxebridge by attempting to discredit all competitors of the widely corrupt International Accreditation Forum, architects of the IAF Accreditation Scheme. The ISOBench.org website makes ridiculous claims that “only certificates with an “MLA” status of the International Accreditation Forum (IAF) deserve the highest level of confidence.” They are clearly paid propagandist of the IAF accreditation racket. MYTH: ISOBench claims businesses must be recognized by the International Accreditation Forum (IAF). TRUTH: There are hundreds of accreditation bodies far superior than China-led IAF. Businesses have a choice to use the accreditation body of their choice, or no accreditation body at all if they so choose. MYTH. ISOBench wants you to believe they are some kind of over-seer on “valid” and “invalid” certifications. TRUTH: ISOBench is operated by an Indian scammer, most likely paid to discredit all competitors of IAF. MYTH: ISOBench wants you to believe they are credible and an actual organization. TRUTH: We could not find a single person to contact at ISOBench. There is no phone number, no e-mail address and no contact information whatsoever on their website. The person that runs ISO Bench-mark is hiding for a reason. They do not want their identify revealed. That’s a red flag for any business, and further proof of the IAF accreditation scam. ISOBench.org is 100% without a doubt a scam and MUST be avoided at all costs. Do not be fooled by these propagandist machine for IAF deceiving businesses about accreditation bodies. Please share this information with other businesses to protect them from the illegal activities of ISOBench.org and its cronies over at the International Accreditation Forum.

2019-04-19T05:04:10Z

Improve player’s ability to pick up ground balls and check an opponent’s stick when the opportunity arises. Enhance players understanding of how, when and why to check a player on a ground ball pick up. of the ball the other player looks to create a turnover and tries make the check and then gain control of the ball. If the player has an opportunity to check they should use the “Out and Away” check. This is a great check that allows you to dislodge the ball and then maintain great body position on the player you just created a turnover with. The key with this check is that it will propel the ball out and in front of you so you can easily pick it up with good body position. Once one player maintains possession the two players head to the opposite end of the grid from where they started. Two players are down at the opposite end are waiting until the player with the ball reaches them. The player with the ball rolls the ground ball out for these two players to go after. The sequence continues.

2019-04-22T14:42:59Z

Heart Disease -­&dash; heart disease is genetic. It is so important to know your individual genetic (Apo E) genotype. Alzheimer's -­&dash; In the past 6 years the US has seen a 47% increase in this largely reversible or preventable disease. Weight Loss -­&dash; The Apo E Gene Diet Program can also help you reach your desired weight. Call today to learn more about The Perfect Gene Diet call today!

2019-04-24T18:54:33Z

Background: Ethanol is a cardiotoxic substance that damages the heart by increasing apoptosis, free radical formation and calcium overloading. Consequently, there is an increase in cell death leaving fewer functioning myocytes leading to heart failure. Sildenafil is a phosphodiesterase type-5 (PDE-5) inhibitor approved for treatment of erectile dysfunction. Studies from our lab have demonstrated that PDE-5 inhibition reduces myocardial infarct size and attenuates post-ischemic cardiac dysfunction in both ischemia-reperfusion and permanent coronary artery ligation models. Therefore, in the present study, we hypothesized that treatment with sildenafil will prevent cardiotoxicity associated with acute alcohol exposure by reducing myocyte apoptosis and preserving cardiac function through PKG signaling. Methods and Results: Adult cardiomyocytes were isolated and treated with 100 mM of 100% ethanol ± 10 µM sildenafil. At 24 hours necrosis was assessed via trypan blue exclusion assay, JC-1 staining assessed mitochondrial membrane potential and ROS production was measured by DCF fluorescence. At 48 hours apoptosis was assessed by TUNEL assay. Ethanol increased the rate of necrotic and apoptotic cell death. This was attenuated by co-treatment with sildenafil. Ethanol disrupted the mitochondrial membrane potential and increased ROS production. Sildenafil preserved mitochondrial membrane potential and attenuated ROS production. Treatment of myocytes with 5-HD, a mitochondrial K+atp channel antagonist, blocked the protective effect of sildenafil. Knockdown of PKG using adenoviral siRNA blocked the protective effect of sildenafil, while overexpression of PKG1α conferred protection against ethanol cytotoxicity. To further demonstrate the effect of sildenafil ethanol-cardiotoxicity in vivo, mice were treated with ethanol (3 g/kg/day) with or without sildenafil (0.7 mg/kg) by i.p. injection for three consecutive days. After treatment, the animals were sacrificed and the hearts removed and perfused on a Langendorff system to measure function. After functional analysis, apoptosis and PKG activity was measured in the heart samples. Ethanol decreased the rate-force product and increased myocardial apoptosis. Sildenafil preserved cardiac function and significantly reduced apoptosis. Sildenafil treated myocardium also showed an increase in PKG activity. Conclusion: Sildenafil attenuates the toxic effect of ethanol by reducing apoptosis and maintaining the mitochondrial integrity in cardiomyocytes. Sildenafil also preserved cardiac function in ethanol-treated mice. Protein kinase G-dependent signaling plays a critical role in attenuating cardiotoxic effect of ethanol.

2019-04-18T17:26:02Z

What is going wrong for Jamie Oliver? This is such an obviously good cause, in my opinion, that, just like Jamie, I am stunned. Why is he having so much trouble getting through to people? What is going wrong for him? What could he be doing wrong? I feel bad for the people he could be helping but isn’t, and, since he’s so adorable, I feel bad for him, too. Since Jamie is trying to change a well-ingrained health behavior, maybe theory can help him? Here, I turn to EPPM, a theory that’s been used a lot to change health-related behaviors. EPPM is a theory that explains when fear appeals work or fail: When they persuade people to engage in the advocated behavior, and when they do not. If it happens to me, how bad could it be? So, let’s see how Jamie is doing. One of his preferred strategies is to show people, literally all the junk they’re putting into their (children’s) bodies: a busload of sugar, 2 gallons of lard. In terms of relevance, the message is clear: yes, this happens to me, I’m the one eating all this in my school’s cafeteria. But in terms of severity, there’s a disconnect. OK, so I ingest a busload of sugar… so what? What’s the problem with that? I think it’s possible that Jamie’s strategy is not driving the message all the way home. It is not helping people understand the consequences of eating a busload of sugar. How bad is it? What can happen to me? I’m feeling fine, thank you. Now, show me someone who suffers from health problems because of having eaten too much sugar, and I may begin to think about it. But make the example too scary and I’ll freak out and shut down. Jamie may be assuming his audience has more knowledge about the dangers of poor nutrition than they already do. This could be why his message fails at the severity level. But let’s assume that Jamie manages to deliver a message that communicates both relevance and severity. That’s still not enough. According to EPPM, two more factors are needed for the message to be persuasive: response-efficacy and self-efficacy. Response efficacy refers to the belief that the behavior Jamie is advocating is capable of actually solving the problem. Basically, that serving healthier school lunches would solve the scary health problems… but wait, he hasn’t quite established those in the first place, as far as I know. Self-efficacy refers to the belief that the person is actually capable of practicing the advocated behavior. Here is where I see a double-layer of problems. At the parent level, it is possible that parents do not feel capable of feeding their children healthier food. I don’t know why, but I’d recommend Jamie do some research and find out. Could it be because they are overwhelmed by the amount of new information they need to learn about nutrition? Could it be because they don’t have the time to cook healthy? Could it be because they can’t afford healthy foods? At the school level, school administrators have to feel they are capable of delivering healthy school lunches now and in the long term. I assume these are poorly-paid, overwhelmed people, who all of a sudden have to figure out a whole new system of food purchasing, delivery, storage, and preparation. Not only is it adding work to an already exhausted system, but it is difficult, and probably expensive to sustain in the long-run. Low self-efficacy, on both the part of the parents and school administrators, may explain why Jamie’s message is not getting through. But wait, there’s more. EPPM predicts that if people perceive a threat (something bad could happen to me – meaning the message communicates both relevance and severity), if either response efficacy or self-efficacy is low, instead of taking action to get rid of the threat (in this case, start eating healthy), they will take action to reduce their fear. This kind of action is counter-productive. It involves freaking out, tuning out, or denying there is a threat in the first place. I think this is happening to Jamie’s audience. Parents may be engaging in fear control processes, trying to manage their fear, instead of managing the threat. This could explain why Jamie seems to be failing to persuade people, why his message is not accepted and people are not engaging in the behavior he advocates. This post is from the series For the Love of Theory, meant not only to help adorable Jamie, but also to demonstrate the power of theory and its capacity to make a difference in the world. But, what other explanations do you have, about what’s going wrong for Jamie? Posted on January 29, 2011 Categories For the Love of TheoryTags EPPM, fear appeals, persuasion, theory1 Comment on What is going wrong for Jamie Oliver? In this post, I’d like to introduce you to one of my favorite communication theories (and if I say that about almost any communication theory, I mean it): symbolic interactionism. I won’t explain the entire theory here, just say that it is a theory about how meaning comes about: through social interaction (communication). One of the meanings that emerges through social interaction is the sense of self. We acquire a sense of self, of who we are and what we are like, through interacting with others. One of the ways in which this happens is that we see ourselves in others as if reflected in a mirror. We grow to believe what we see in those mirrors. That explains why, when faced with people who believe we’re stupid, we second-guess ourselves, we become stupid. When around people who believe in us, we raise up to those expectations. It explains the influence parents have on us – they are the mirrors we see ourselves in when we’re little and fragile, and those mirrors influence who we become (reason 65,492 why I’m scared to become a parent). It explains Theory X and theory Y in management and education. Of course, there are several factors that come into play, and we can’t entirely hold others accountable for who we are. But to a large extent, who we are depends on our history of human interaction, according to symbolic interactionism. We seek people in whose mirrors we see images of us we like – as we should. So now, let me turn this around, and apply it to building relationships online. You are a mirror. You reflect others’ images back to them. How do people see themselves in your mirror? Ask yourself – what must this person think I think about them? Who do they think I think they are? How do they see themselves in the mirror that I am? Your attitude and beliefs about people, as manifested in your communication, form this mirror. Do you show the best in people, or are you the kind of mirror that emphasizes the weaknesses, the negatives? One way of building relationships (online and off) is being the kind of mirror people seek to look into, because they like what they see, or because they’re amused, or because it helps them grow – or just because, it makes them feel good. So, remember, how you see people is often how they come to see themselves – especially if they’re young and fragile. Being quite a critical spirit myself, I struggle with the burden of the practical implications of this theory. There are implications for personal relationships, but also for management, education, PR, marketing, advertising, Web usability, to name a few. What sense do you make of this?

2019-04-18T23:04:19Z

Roessingh Research and Development (RRD) is the largest Dutch scientific research centre for rehabilitation technology and telemedicine. RRD has a formal partnership with the University of Twente for researching, developing, evaluating and implementing ICT-supported health services. RRD develops its innovations via multidisciplinary, often international, collaborations. RRD aims to transfer their academic insights into clinical practice, and economic activity. RRD developed an online, multidimensional screening tool to self-assess general health status, physical, cognitive and nutritional state and self-management modules for physical training. Additionally, a module for unobtrusive monitoring of daily life functioning and emotions and an intelligent decision support corewas also developed. All modules are integrated in an interoperable platform as well as a playful environment enabling training in a game environment. These technologies have been brought together in Langgezond.nl, RRD's spin-off initiative. Municipalities and general practitioners (GP) offer online self-assessment. Aged people are then contacted by a GP or municipality/social welfare organisations for online self-management modules. Structural cooperation with educational institutes, nursing students (secondary and higher education) support seniors in using technology and health assessments. Since April 2016 it has been offered to over 10,0000 aged persons via more than 30 GP’s in 4 municipalities with the involvement of 6 welfare organisations. The societal RoI (Return on Investment) is positive with costs of ± €19 per user paid to the entity by municipalities. This innovation is foreseen to be scaled up to 14 regional municipalities in Italy around 2016/2017. The work within the framework programme has contributed significantly to Langgezond.nl. It enabled us to put together expertise from different clinical and technical domains needed for the service modules. In addition, it offers the perfect mix of expertise from research to implementation, including business modelling. Also, the EIPonAHA, where RRD is actively involved in Action Groups as well as in our Reference Site, Twente, was important. Without the European framework this innovation could not have been realized. See the list of academic publications related to perssilaa.

2019-04-18T11:30:23Z

Demolition of the Goodman Building has begun and is expected to take around four months. The building has been surrounded by scaffolding and hoardings for several weeks while fixtures and fittings, including windows and the front door, have been removed. The building will now be demolished from the top down, with material being routed down the central atrium to the ground floor for disposal. It is expected to take around two weeks for each of the building’s five storeys to be demolished. I had an opportunity to visit the top of the building just before the roof was demolished. After climbing several flights of dimly-lit stairs and two vertical ladders I found myself on the roof, which was already covered in rubble and debris. As you can see I had to wear steel-toed boots, a high visibility vest, safety goggles and a hard hat. I was struck by the amazing views of London in all directions – the views from the upper floors of the new building will be impressive.

2019-04-22T17:01:57Z

The late modernist architect Bud Oglesby and Joseph Minton collaborated on an un-modern masterpiece. DINING ROOM: Pat Williamson wanted the dining room to adjoin the breakfast room “to accommodate large family gatherings – so laughter can spill over from one room to the other.” English Regency mahogany table and Italian reproductions of Georgian chairs with carved eagle arms were in the former house. Cut velvet fabric from Brunschwig & Fils. Antique Persian rug is a Bakshaish. The chemistry between the late modernist architect Bud Oglesby and interior designer Joseph Minton proves to be powerful. COURTYARD: Courtyard and circular driveway are centered by a bronze fountain. Roman-arched doors, French windows, and dormers allow light to stream into the house. Genius is not only the superior power of invention or origination; it’s also energy – the mental, physical, and emotional energy necessary to form new combinations. When Pat and Don Williamson decided to downsize their living space after raising their three sons, they enlisted the help of two close friends – the late, celebrated Dallas architect Bud Oglesby and the equally celebrated antiques purveyor and interior designer Joe Minton. The chemistry proved potent – collectively, the group designed a house that fuses classical and Mediterranean modern elements with Texas scale and panache, creating a design that is sui generis. The couple met as students at Texas Christian University. After they married, they bought a Gothic mansion set on 6 acres in Westover Hills, an incorporated city inside old Fort Worth characterized by stately houses and undulating landscapes. Don Williamson and Minton had grown up here and, as a youngster, Minton imagined that the castle-like abode his friend would one day occupy was the home of Old King Cole. A friendship between the Williamsons and Oglesby had blossomed out of a shared love of sailing on Fort Worth’s Eagle Mountain Lake, so it was natural that the Williamsons commissioned Oglesby’s architectural firm, Oglesby Group (later reformed as Oglesby Greene), to design their new home. From the outset, the Williamsons also involved Minton, with whom they had twice vacationed on the Côte d’Azur. “Some friends rented a huge villa for two months every summer in Cap Ferrat,” Pat Williamson says. Those visits to the south of France left lasting impressions on both Minton and the Williamsons by influencing their design aesthetic. Meanwhile, Bud Oglesby had built his firm’s reputation on adapting to Texas the simplified shapes and industrial idiom of European modernism. To design what the Williamsons had in mind was to be quite a departure. LIBRARY: Coffered ceiling in library is walnut. Black Belgian marble coffee table from Knoll was designed by leading Italian architect Gae Aulenti. Minton found the 18th century marble fireplace in France. For days, the Williamsons and Oglesby drove around Dallas looking at houses for ideas. “We also looked at the houses that Bud had built, which were all modern,” Pat Williamson says. “We went into some of those houses, and I got butterflies. Finally, I told Bud. ’I don’t want a modern house. Tell me truthfully, can you do this – design a house that’s not modern?’” Oglesby was confident that he could. Ultimately, a house in University Park was to be the inspiration for the Williamsons’ dream house. “One that I thought was neat was a large, stone house with a slate roof,” Pat Williamson says. An accomplished gardener with an artistic bent (one son is also an artist), she insisted that the house be open to natural light. “I wanted to be able to look anywhere within the house and be able to see outside,” she says. In order to visualize “the repose of the residence” (a favorite Oglesby term meaning where the home sits on the lot), Oglesby moved in with the Williamsons for several days. He determined that the new house should be set back further from the road than where the Spanish house had been. That would leave space for a circular driveway and a bronze fountain centering the courtyard. A gleam started to quicken and take shape. Oglesby assigned Kraig Post as project manager. “Every Tuesday we convened in a mobile home parked on the site – the contractor, Don, Pat, Kraig, me, and my assistant. We did a lot of research on classical architecture, particularly on Palladian-style houses. Plus, Pat had collected photographs of her favorite design elements such as interior windows with little wrought-iron balconies we had seen in the south of France,” Minton says. One formidable challenge was to figure out how the stone façade of the Dallas house had been created. Working with stonemasons, Oglesby and Post discovered that the old-fashioned “shot-sawn” method of cutting limestone produced the requisite color and texture. BREAKFAST ROOM: This room features a pencil drawing by the Williamsons’ son Alex. Walls are covered in a twig-and-berry Minton-designed paper. After two years of construction, what emerged was a beautiful stone house of classic proportions that could sit as comfortably in the French countryside as in Fort Worth. Its slate roof is set with three dormer windows. To compensate for optical distortion, the roof tiles become smaller as they recede to the top, making all the tiles appear to be the same size – similar to the way the columns of the Parthenon are subtly curved in order to appear straight to the eye. The balcony of the front loggia is dripping with vines, and two enormous magnolia trees flank its columns. Yes, the house is smaller than their previous one, but by any measure, the Williamson home is grand: Its immense front hall, rising through two stories up to a wood-beamed ceiling, is as large as many houses. The Roman-arched front door with its large panels of glass inset in iron affords a view straight through the house to the back terrace, beyond and below it is an enormous swimming pool. Grand staircases sweep up from both sides of the hallway. Two walkways cut across the house”one above the front entryway and another across the two bedroom wings. The living room, dining room, kitchen, and greenhouse are five steps below the entrance level. Except for the bathrooms and kitchen, the downstairs is paved with slabs of limestone. (“Marble is too hard on the feet,” Pat Williamson says.) At Minton’s behest, painter Ed Ackermann finished the walls to simulate the look of old plaster. The furnishings are a mix of English, French, and Italian antiques, many from the Williamson’s previous home, for which Minton was also the interior designer. Pat Williamson’s greatest joy was in choosing fabrics. “I went into Joe’s fabric room and had a blast,” she says. Her picks? Most are from Bennison, the English company that specializes in hand-printed fabrics based on original 18th and 19th century English and French textile designs. Most are floral or leaf patterns, reflecting Pat’s love of nature. Sadly, Bud Oglesby didn’t live to see the final completion of this challenging project, one of the last houses he designed. He did, however, view it several times as it neared completion. “He was quite proud of it,” Post says. Thirteen years later, the house looks as though it’s been there forever. Perhaps that’s the real genius behind it. BEDROOM: Walls, curtains, duvet, headboard, and chair in the guest bedroom are covered in a variety of Bennison fabrics, artfully mixed by Minton.

2019-04-25T10:15:58Z

At MCMC Internal Medicine we strive to provide team-based, patient-centered care that treats the whole person –body, mind and spirit. Our mission is to help you stay as healthy as possible, and this is best accomplished when there is a partnership between you and your provider. We accomplish this by listening closely to your needs and empowering you with information that helps you to reach your health and wellness goals.

2019-04-26T00:05:01Z

Bombay High Court System Officer Vacancy. Bombay high court Maharashtra Has on 12th Feb Invited Online Application Form for Senior System Officer and System Officer Posts in Bombay High Court of Maharashtra. The Interested Candidates Can Read the Full Notification Before they Apply Online form. To qualify for Bombay High Court Senior System Officer: candidates Must hold a Degree of B.E. or B.Tech. In Computer Science or Engineering or Information Technology or Electronic Engineering or any equivalent qualification from recognized University with the five-year of experience. They Must hold a Degree of B.E. or B.Tech In Computer Science or Engineering or Electronic Engineering or MCA or any equivalent qualification from recognized University with five-year experience. System Officer: Qualification -:Must hold a Degree in B.E. or B.Tech. In Computer Science or Engineering or Information Technology or Electronic Engineering or any equivalent qualification from the recognized University with prior one year experience must. Must hold a Degree of B.E. or B.Tech. In Computer Science or Engineering or Electronic Engineering or MCA or any equivalent qualification from the recognized University with one year experience. Applicant should Go through the notification for detailed eligibility criteria. ₹ 40000- 46000 Per month. The Selection will totally depend on the basis of Interview. For Gen and UR Candidates Maximum Age 40 Years. Candidates should log on to https://bhc.gov.in/bhcrecruit/recruitment.php. First Complete the Registration and Click on “Submit”. After the Registration, candiate Log in with Registered Number and Password. Fill all details in the given application and upload Photo, Signature. Take a print out of candidates Online application for future use. We hope that you got idea about Bombay High Court System Officer Vacancy.

2019-04-25T17:53:09Z

Who starts or how we start seems very much to change from piece to piece. Body Not Fit For Purpose (2014) is their first overtly political work, taking as its starting point the uselessness of dancing to express anything of any real concern and at the same time the inherent, gloriously foolish radicality of the attempt. Built on the structure of La Folia, one of Europe's earliest remembered melodies, the performance takes place at a table with Fargion's mandolin counterpointing Burrows's gestural language. Clashing an angry politic against the empty joy of dancing, unravelling the link between meaning and action this work raises questions in the midst of laughter. Adrian Heathfield is a writer and curator working across the scenes of live art, performance and dance. He is best known for his books, which include Perform, Repeat, Record: Live Art in History and Out of Now: The Lifeworks of Tehching Hsieh. He co-curated the Live Culture events at Tate Modern in 2003, was co-director of Performance Matters (2009-14) and has curated a number of durational events in European cities over the last ten years. He is the co-author with photographer Hugo Glendinning of a series of dialogue films with figures such as Hélène Cixous, Alphonso Lingis, Brian Massumi and Bernard Stiegler. Adrian is Marie Curie International Fellow at Columbia University, New York where he conducts a project called Curating the Ephemeral and he is Professor of Performance and Visual Culture at the University of Roehampton, London.

2019-04-24T18:16:57Z

Come one come all to the best Ravens Tailgate of all! You don't have to wait till September to show your pride for the Baltimore Ravens. From May 31 - June 3, Ocean City with be overflowing with purple for the first ever Ravens Beach Bash. In the past this has been primarily a Ravens Roost convention but this year will be open to the public and will include a ton of special events including a bonfire on the beach, beach games, parties all over town, a parade and more. See the full Ravens Beach Bash schedule and start planing your trip. And if you book one of our Ravens Beach Bash Ocean City hotel packages you'll get a Ravens gift bag, free or discounted drinks at happy hours all over town and a private meet and greet with a LIVE Raven!! Help us paint the town purple! Who are the OC Insiders - Meet Darlene! When planning your trip to Ocean City, MD it seems that everyone and their brother has an opinion about which event is best to check out, what hotel you should rest your head in, or where you should grab your Happy Hour drink. However, one thing many of you may not have heard about is an amazing group of individuals who can say without a doubt that they are the experts on Ocean City, MD. Who is this group you may ask?! None other than our own OC Insiders! How does Ocean City Golf Club stand out from the others? For starters, not only is it a yacht club but it also has TWO golf courses. Secondly, other courses don’t have Buddy Sass. It is not every day you meet a man like Sass; he has been head of the pro shop for Ocean City Golf Club for nearly 14 years. His air of confidence on the sport convinced me he was capable of answering all of the amateur-ish questions I could muster up. Enhance team spirit and build the capacity of your group with Beach Games! These are fun and active games that get everyone acquainted, working together and enjoying the outdoors together. Challenge your meeting participants to explore their thoughts, feelings, attitudes and knowledge to achieve goals as a team while engaging in one of the most beautiful environments - the beach and Atlantic Ocean! Tucked away next to the bus station on the corner of South Division and Baltimore Ave, Henry’s Hotel was built in 1895 in a time when Ocean City was deeply segregated. It’s astounding to think there was a time when music legends like Duke Ellington, Cab Calloway, Count Basie and Louis Armstrong came to Ocean City, performed in major hotel ballrooms yet were not permitted to sleep in the same hotels where they performed. Instead they stayed at Henry's Hotel. There's nothing like the smell of fresh salt air. But mix in the scents of some newly laid boards and it only gets better. The Ocean City boardwalk project is a 2 year project but the south end is already looking great. The North end is getting there too, but they still have a few streets to go. Check out some more Ocean City boardwalk construction pics on flickr.

2019-04-19T22:52:26Z

Here are some 60 Medicine Cabinet at Ceiling Wall Ideas Design new images can provide to you. If you want to save the image, just select the picture you want, and then save it to your device. Not a large selection images of 60 Medicine Cabinet new you can select according to your preference. 60 Medicine Cabinet new is just one of the many collection of images or pictures that are on this website. you will get a lot of information here. Not only do we provide information about unique, you'll get a lot more references to design the home of your dreams. So visit Ceiling Wall Ideas for updates on home design, kitchen, bedroom, bathroom, living room, bedroom and furniture and much more.

2019-04-19T22:17:30Z

The Calgary Comic & Entertainment Expo is Canada's largest Canadian owned pop culture event. Featuring a myriad of special guests from film & television, comic books, sci-fi, horror, anime, cartoons & collectibles, this family friendly event caters to every fan of every genre. The show spans over 418,000 sq. ft. of space; packed with programming, vendors, artists, and special guests.

2019-04-25T18:49:08Z

Rice University’s Baker Institute for Public Policy is ranked No. 3 among the best university-affiliated think tanks in the world and its Center for Energy Studies is the No. 1 energy- and resource-based think tank, maintaining their high rankings from the previous year, according to the 2018 Global Go To Think Tank Index Report published this week.

2019-04-21T09:33:50Z

The best photos, images, photography of Macaw. View and get inspired by this glorious and amazing macaw photo gallery showcase full of pictures and macaw images. Beautiful photos of nature and interesting places.

2019-04-26T02:16:31Z

LEC Archives - This Is My Joystick! Here's a breakdown of the content on This Is My Joystick that contains the tag LEC. All our editorials, reviews and features are filtered below.

2019-04-22T02:11:25Z

Baby teeth aid enunciation and speech production, help the child to chew food correctly, maintain space in the jaw for adult teeth, and prevent the tongue from posturing abnormally in the mouth. When baby teeth are lost prematurely due to decay or trauma, adjacent teeth shift to fill the gap. This phenomenon can lead to impacted adult teeth, years of orthodontic treatment, and a poor aesthetic result. Babies are at risk for tooth decay as soon as the first primary tooth emerges – usually around the age of six months. For this reason, the American Academy of Pediatric Dentistry (AAPD) recommends a “well baby check up” with a pediatric dentist around the age of twelve months. Acid-producing bacteria in the oral cavity cause tooth decay. Initially, these bacteria may be transmitted from mother or father to baby through saliva. Every time parents share a spoon with the baby or attempt to cleanse a pacifier with their mouths, the parental bacteria invade the baby’s mouth. Especially when sweetened liquids are used as a naptime or nighttime drink, they remain in the mouth for an extended period of time. Oral bacteria feed on the sugar on and around the teeth and then emit harmful acids. These acids attack tooth enamel and wear it away. The result is painful cavities and pediatric tooth decay. Cleanse gums after every feeding with a clean washcloth. Do not place sugary drinks in baby bottle or sippy cups. Only fill these containers with water, breast milk, or formula. Encourage the child to use a regular cup (rather than a sippy cup) when the child reaches twelve months old. If you have questions or concerns about baby bottle tooth decay, please consult your pediatric dentist.

2019-04-21T04:29:38Z

Thing is, when you have lots of followers around the web to begin with, you'll get more reactions, no matter if there's better content on the same topic. This behavior will not lead to more followers, views or clicks. If the article is good, it will definitely get attention, even without all the flames.

2019-04-25T13:53:19Z

 Lecture "Adjudicating Islamic Family Law in Egypt: Continuity and Rupture"- Rechtsstandort Hamburg e.V. Am 14.12.2017 findet im Max-Planck-Institut für ausländisches und internationales Privatrecht ab 16:00 Uhr ein Vortrag zu dem Thema "Adjudicating Islamic Family Law in Egypt: Continuity and Rupture" statt. Referentin ist Monika Lindbekk (University of Oslo).

2019-04-18T22:20:52Z

Listed by Nina Chou PREC* of Multiple Realty Ltd. Listed by Nina Chou PREC* and Michelle Wang PREC* of Multiple Realty Ltd. Listed by Sarah Guo PREC* of Multiple Realty Ltd. Listed by Jack Liu PREC* of Multiple Realty Ltd. Listed by Vivian Hao PREC* of Macdonald Realty Westmar and Michelle Wang PREC* of Multiple Realty Ltd. Listed by Ada Tse of Multiple Realty Ltd. Listed by Randy Wong of Multiple Realty Ltd.

2019-04-20T00:17:08Z

Our vision is to have a substantial positive effect on the welfare of athletes, athletic performance and sports medicine through sports chiropractic on the international stage. Our priority is to focus our attention on the support of underserved athletes of all levels. To have a profound impact on the international sports medicine community through sports chiropractic. To aid the ability of all athletes to have access to sports chiropractic care as an integral part of their health care, preventative care and sport performance. Education – We are actively looking to align our foundation with institutions and programs that promote sports chiropractic and the treatment of challenged athletes. Scholarships – We identify exemplary candidates in Chiropractic and/or Master of Science in Sports programs for financial support. Research – We support research in the field of sports chiropractic. Doctor Support – All doctors volunteer their time and expertise through FICS to insure the health and athletic performance of all athletes. The Foundation looks to support those highly qualified doctors who want to participate but feel the financial constraints traveling to distant and at times remote locations. These individuals are supported on a case by case basis. A large majority of the monies raised goes directly to event support, athlete support, doctor support and support of our educational and research institutions. Currently all members of the Foundation Board of Directors volunteer their time and spend their own resources when communicating and traveling to meetings. The Foundation does use independent contractor services for administrative services and for certain specialty services that cannot be performed in house. **is a registered not for profit in the State of Massachusetts and has been granted section 501(c) (3) by the IRS in the USA.

2019-04-26T08:10:22Z

The residents at Ingleside at King Farm (IKF) have been working hard all year preparing for the community’s 4th Annual Bazaar on Saturday, Nov. 12. As the saying goes, “it takes a village” to successfully put on an event such as this. But Ingleside’s community is up to the task. We all know exercise is good for our bodies, and new research is showing that aerobic exercise—the kind that gets you breathing hard and your heart pumping—can reinforce learning and play a role in storing information in long-term memory. A recent study at Radboud University in The Netherlands and the University of Edinburgh found that exercise performed four hours after a learning task boosted the subjects’ ability to remember the learned material. With every step they take on Oct. 7, 2016, staff and members of Ingleside at King Farm, along with friends and families, will be supporting the fight against Alzheimer’s disease. Residents, staff members and guests will be participating in the retirement community’s Walk to End Alzheimer’s, the nation’s largest event to raise awareness and funds. Money raised during this annual fall event supports research and provides programs to improve the lives of families affected by Alzheimer’s and dementia. Total wellness involves more than just physical health. A state of well-being involves multiple factors that take into account our lifestyle and interaction with the environment that surrounds us. Achieving total wellness is an ongoing process that enables us to achieve our full potential and highest quality of life. At the Ingleside, we promote the Six Dimensions of Wellness. This holistic model, developed by Dr. Bill Hettler, a cofounder of the National Wellness Institute, includes Spiritual, Social, Emotional, Vocational, Intellectual and Physical Wellness. In this series of posts, we’re exploring each of those dimensions and how they are supported and practiced at Ingleside at King Farm.

2019-04-24T12:35:23Z

01:16 Cumshot front and back! 05:37 Impressive blonde is getting naked in the bedroom! 01:21 HD I Think I was horny!!!

2019-04-20T15:04:12Z

Northwest Propane has been providing propane autogas mower and vehicle engine conversion and refueling services to landscapers in Texas for over 20 years. Our customers have seen firsthand all the benefits propane offers and continue to win new opportunities as more commercial property owners invest in LEED certifications and show preference to greener, environmentally friendly services. Interested in learning about how propane could improve your company’s costs and image? Contact us for a free consultation, and we will be happy to walk you through all available options and funding incentives. Propane Success Stories -Earthwork, Inc. Propane Success Stories -Benchmark Landscape. Why Choose Propane Mowers ? Click below to find out more !

2019-04-25T14:24:32Z

“Fuse” is a series of algorithmically generated collages of everyday views. The synthetic images are created from many different photos from the same sites by rather simple, custom algorithms. The results appear to be quite realistic, but not quite—the attentive viewer soon realises that some things in them do not add up, and the illusion of reality (or the representation thereof) falters. The work consists of several parts: A selection of still images is printed on 20 by 20 cm boards. A variety of serial images is printed on photo paper in 10 by 15 cm and shown in a photo album. The third part is an animation which shows 'infinite landscapes' that are continuously stitched together in real-time. One might be inspired by these short-lived illusions to challenge our perception of everyday phenomena as well as mediated images of the world, and our romantic image of “nature” and authenticity.

2019-04-20T06:13:44Z

“It was a great evening. I got a charge out of the flute player. Most of the jazz flute players I hear are delinquent Sax players. She has a real solid sound and technique.” 3-15-2015. “I loved the flute player. Great sound and feel.” Richard Moxley. "It is really a pleasure to play with another person that has a very good level of training as you do in the way you handle the air is especially very sensitive and very good. You understand the value of elegance in your playing and the way you connect notes." Gordon Halligan, July 2014. "Wow...., I never tapped my foot to communion before. We hope that you come back soon". Congregant. Longboat Key Chapel. September 2004. "I've really enjoyed the CD - you sound fantastic with such a beautiful warm tone and oozing musicality. Kokopelli is so haunting, I must dig out the music for it and play it again - you've inspired me!" Bridget Douglas, principal flutist in New Zealand Symphony Orchestra. "Really well done. Your disc is beautiful! Great variety of music and beautifully played....people are really going to enjoy." Gregg Moore, Eureka, Calif. musician , composer, arranger. "Congratulations on such an enchanting piece of work! Your insight, talent and expressive phrasing are very impressive and delightful". Dr. Mary Gruber, Statistics Professor at Humboldt State University. "This CD displays Hoffman's rich tone and mastery of great variety of styles ranging from jazz to folk music to new age to contemporary concert music. It shows a working professional who can cover all the bases and appeal to a wide audience. She is definitely "a crowd pleaser." Jerry Pritchard, editor and CD concert reviewer of Flute Network and Professor Emeritus of Flute at California State University at Riverside California. Student: "I don't know what I would do without my weekly lessons at the school. It is really an inviting place. A great place to learn. My teacher is really awesome." Parent: "this program is really rewarding for the kids and beneficial for their self-esteem."

2019-04-19T18:30:36Z

Thirst: a strong desire for something; a lust for attention. Thirst trap: An image or video that’s intended to attract attention from someone and elicit a response. “It’s like you’re throwing out a net into a sea of fish,” Mr. Yau said. “Whenever I post a story, I kind of have an idea already of who will respond or what kind of response I will get.” If you are successful, the person you are targeting will be tempted to comment. Might even actually comment. Might even “slide into your DMs.” If so, you have pulled off your very own thirst trap.

2019-04-18T10:57:14Z

Carmen Apartment provides serviced accommodation in Ticinese, Milan, eight kilometres from Linate Airport and just an eight minute walk from Missori metro station. The property comprises one bedroom with a double bed, one bathroom with a shower only and a basic kitchenette with an electric fan oven, four electric cooking rings and a fridge/freezer. At approximately 45 square metres, the apartment is decked with wooden flooring and features central heating, built-in air conditioning, a washing machine, a dining table, chairs and a television. Free wireless internet is provided throughout the stay. Guests receive a complimentary welcome pack on arrival and maid service is provided once a week.

2019-04-19T00:28:46Z

There is a cry for Spiritual fire. Intercessors are taking to their prayer closets crying out, “L-rd, have mercy upon us in these days as trouble appears.” For the past several years, the L-rd has gathered prayer warriors from throughout the Earth. They have been preparing to be used as intercessors. Now the call is out to begin to pray for the Spiritual fire to come upon the redeemed. This is not a call for revival. This is not a call to repentance. This is a call for the Spirit to fall upon those who have already repented, who have already received the L-rd and Savior Y’shuaJesus into their hearts. death shall be their shepherd, and the upright shall rule over them in the morning. Their form shall be consumed in Sheol, with no place to dwell. To resist this identification mark, we will need Spiritual Fire to burn within our hearts. We need to be as the as those who gathered in the upper chamber on the day of Pentecost, when tongues of fire entered the disciples of Y’shuaJesus. In a world turned upside down. . .

2019-04-21T02:22:02Z

Yang, Jun, Liu, Hongbo, and Yang, Wenqian (2015) The impacts of China's economic policies on Sino-African agricultural trade: evidence from the Gravity Model Analysis. China Finance and Economic Review, 4 (1). pp. 101-115. The rapid economic growth of China and some African countries provides tremendous opportunity for the agricultural trade. Both China and African countries have made great efforts in achieving win-win cooperation between the two economies. This paper aims to provide a comprehensive analysis of impacts of various factors on bilateral agricultural trade between China and Africa. The fixed effect Gravity model is adopted in the study to assess the impacts of different factors on Sino-African bilateral agricultural trade, based on the various datasets covering 1992-2010. The economic growth and rising agricultural production are found to be the two key factors to drive Sino-African's future bilateral agricultural trade. Therefore, the focus should be put on the long-run effects of investment in promoting bilateral agricultural trade. Moreover, the agricultural cooperation should be enhanced to improve the agricultural production and fully use the comparative advantages in both sides.

2019-04-18T14:18:03Z

Fake Employment . USA and United Kingdom . Reshipping Scam .

2019-04-20T15:15:19Z

Yesterday, Russia launched its autonomous resupply spacecraft Progress into space. The International Space Station passed over the launch site at about the same time, offering the astronauts on board this amazing view. Sunset occurred for us about a minute later and shortly after we caught site of the rocket ahead and below us from the Cupola. We continued to catch up to it until it was directly below. We saw the flash of 3rd stage ignition and the subsequent 3rd stage was spectacular.

2019-04-24T02:41:51Z

Florida - South We are located in Miami-dade County. Our main lines of business include: Electrical Contractors, General Contractors. J.P. Moran, Inc. has been listed in the Blue Book since 1989. To : J.P. Moran, Inc.

2019-04-23T08:40:14Z

In an announcement made late last week, Google parent Alphabet and Getty Images made a sweeping partnership that ended a long-standing copyright antitrust dispute between Getty and Google, which was filed in early 2016. According to The Verge, Google is also making copyright attribution and disclaimers more prominent in image search results and is going to remove links to stand-alone URLs for Getty photographs. Getty isn’t the only party to make these types of claims against Google over the years. Getty felt that Google was being coerced into participating in Image Search and complying with Google’s image format requirements despite its copyright-related objections. But now, these charges have now reportedly been withdrawn in the wake of the just-announced deal. Getty has been the world’s largest repository and licensor of images, and has bee a very aggressive litigant (a “copyright troll“) in its effort to protect licensing revenues or extract additional revenue from as many infringers as possible, some of whom were unwitting.

2019-04-24T04:50:56Z

Have you ever questioned how the vehicles on used car heaps all look so good? They have all been given a as soon as over by an expert in auto detailing, recognized formally as supplier preparation”. Copyright laws is subsequently creating an enormous accessibility problem for blind and visually impaired persons around the world. The World Blind Union, supported by plenty of South American nations, proposed a Treaty at the World Intellectual Property Organization in Geneva, for Blind, Visually Impaired and Studying Disabled Persons. No one —effectively, hardly anybody—can nonetheless be satisfied that brutal means are justified by mythological ends. And people are much less more likely to believe employers’ and companies’ false guarantees of future rewards for years of loyalty now. Nevertheless it has not actu- ally brought us into better consciousness of what is going on round us. I am with you on what you are saying. Not so way back a really well know particular person stated that Australia was at risk of changing into a nation of ‘merchants’. The Auto Trade is a traditional instance of that scenario. We have misplaced just about all manufacturing of auto parts to nations like China that can produce issues cheaply. (lets not point out high quality) The only Auto manufacturers of any notice left in Australia are Ford Motor Firm and Normal Motors Holden (parent firm General Motors) with some Toyota production in Victoria.

2019-04-25T23:58:37Z

Of all, it is essential that you understand the studies of fulfillment degrees over purchasing a cushion has given comparable outcomes to those that purchased them on-line as well as offline by visiting a shop. Of all, the benefit of actually obtaining to attempt on the cushion that you get when you go to a shop is normally covered by thousands of customer evaluates one can locate on-line. If a thousand out of thousand people are claiming that a cushion is comfy, the opportunities are it is in truth comfy. For an example, the example bed mattress that you are trying on in the shop has actually been attempted on by several individuals before. You will not get that comfy feeling with your brand brand-new mattress until after a couple of weeks when it is utilized for a while. Now that you know purchasing a cushion online will certainly not make you be sorry for at the end, allow’s see the things you can do it make your decision as far better as feasible. mattress world track my order There are mattresses which are better for back sleepers than side sleepers. Know exactly what you are going for, and also after that start searching for the cushion that would certainly match all your requirements. As mentioned over too, among the biggest benefits of online shopping is the access to countless user evaluations. If the users are confirmed, the chances are that they would discuss more the weaknesses of an item that its great points– this is natural for us people and it fantastic for you as a new buyer to weed out the products that do not match you. Check out a minimum of 20 testimonials by previous individuals prior to you make the last choice. The even more evaluations you could check out the much better. There are uncommon opportunities that a product is a whole lot far better compared to what it has actually been described by the users, yet most of the time if the reviews are credible, it would certainly provide you an excellent understanding into the experience of using the mattress that you could not obtain from anywhere else. An additional problem when you buy mattress online is the expense. Usually, purchasing products on-line included an extra price for the shipment. There are many mattress firms on-line which would certainly organize the shipment for totally free. Spend some time to try to find them. Otherwise, you would certainly be shedding your advantage of getting online. There are sales in the stores nearing seasonal times of the year. Aim to get huge products like cushions for sale where occasionally they provide to 50% discount rates. Watch on voucher offers as well. If you have a little patience to do some good excavating on online, you will probably be able to acquire the best cushion for the best rate feasible.

2019-04-26T08:05:16Z

Nice to be inside with the family. What? Don’t you want God to use you for His purposes? Don’t you want Him to use you to bring people to Christ? Don’t you want Him to use you to change the world for the better? No, I don’t think so. Let me explain. Oh, please do. This should be rich. I think you’ll understand with three simple sentences. He used me to get what he wanted from you. She used me like a cat uses a mouse. Would you like some true-to-life examples of being used by someone? A father drives his son to be a great baseball player. The father uses the son to live out a lost dream. Parents go through an ugly divorce and use their children to hurt one another. Do you still want to be used by God? Use is an appropriate term for what we do with tools, athletic equipment, or dinnerware. It’s not appropriate for what we do with people. Or what God does with us. So what does God do with us? That sounds like an invitation to me. Come. Let’s think about this for a moment. Yep, definitely invitation, one and all. I think an invitation is both what we long for and what we fear. Long for. Ellen and I attended a Reds-Astros game in Cincinnati many years ago. We had nice seats looking out from the 3rd-base side of the field—lovely view of the Ohio River. We also had a bird’s eye view of the luxury box right beneath us. We were well within smelling range. When the luxury-box attendant brought out a large plate of fresh-baked cookies, I longed for an invitation to be one level closer to the field. We often feel like we’re on the outside looking in. We long for an invitation to join the group. Fear. Standing outside in the cold, we can appreciate a fire’s warmth. Being invited inside by said Fire is another story altogether. We desire warmth but fear getting burned. I’ll address fear more in another post, but suffice it to say, although God invites all, not everyone comes. But His invitation remains, and God is patient. He’s willing to do the hard work of wooing us to Him. So why would you want to be used by Him? Wouldn’t you rather be invited to know Him? And wouldn’t you rather extend His invitation to others? I’m curious. How has an invitation influenced your life? What place or event would you love an invite to? This entry was posted in Uncategorized and tagged community, Evangelism, feeling used, God, God's call, Invitation, serving God, used by God. Bookmark the permalink. 5 Responses to Do You Want to Be Used by God? loved where you took this. I had not thought about it that way. thanks! You’re welcome. I think it keeps me from worrying so much about faith issues, how do I “witness,” etc., and allows me to live out my faith instead. Yep, just let that little beam of light shine right on through! Stay warm my friend. Makes me think of the many people in the Bible who were used by God but who didn’t even believe in Him. He can use anyone, even those who don’t believe in Him and commit their lives to Him. Being invited makes life with Him a partnership, and oh what a joy that partnership can be. Terrific perspective, Tom! Thank you once again for challenging me. I’m reading in 2 Kings these days, and your statement, Kari, really comes alive when reading about Ahab (Jezebel’s husband whom God helped to defeat the Arameans) or the four outcasts who brought good news to a starving city under siege. God does amazing, grace-filled things to an undeserving people.

2019-04-24T06:55:21Z

Jackman, Maine Lodging and accommodation Info! Stay at a Jackman, Maine Bed and Breakfasts and Inns for the personal attention you desire. A Jackman B&B is a great alternative to hotels or motels while visiting the state of Maine! Visit our Jackman, Maine bed and breakfast directory of historic, romantic, and adventure B&B's. You can browse through our detailed listings of Jackman, Maine bed and breakfasts and inns with nearby city listings that include pictures, room rates, booking information and area activities. Every Jackman, Maine b&b inns has complete contact information and a direct link to the innkeepers.

2019-04-25T09:52:15Z

So you love to hunt or want to hunt. And you want to use a “primitive weapon” such as a bow and arrow. There are hunters with guns and hunters with bows and arrows. The reason you would want to choose a bow is to make it a very personal encounter with the animal. You have to come up close and so close that you might hear the animal breathe, or even see its hair moving in the wind. If you would love to experience this, then you are on the right track. Archery is a specialized sport but with enormous satisfaction and a high sense of accomplishment. It is an extremely rewarding experience since every deer and every hunt is different. Buying your very first bow might seem challenging but you could be surprised as to how easy it is. In order to prepare physically and mentally for your first shoot, you will have to obtain your bow and arrow as quickly as possible. Choose a bow that has a wide range of adjustments to make. These adjustments should also be easy to make. The bow should fit the shooter perfectly in order to work properly. It usually takes several rounds of adjustments to get a bow to work 100% for a new archer. You want this to be easily done and not struggle with complicated adjustment settings. This will easily discourage a new excited hunter. Look out for specials and do not overspend on your first bow. You still need some funds for extras and accessories. While it seems to be a good idea investing on top of the range, high-quality arrows, it might not be necessary for a new archer to spend a fortune on this. There is usually a steep learning curve which includes losing arrows. For new-time archers, the basic carbon arrows will do perfectly well. They are tougher, quieter, and faster and are often cheaper than the aluminum ones. In any hunting situation, the broadhead is probably one of the most important pieces of equipment you could invest in. Its relevance is determined by the fact that no matter how much you spend on arrows, rests, releases, and targets, it is the broadhead that matters most when the arrow strikes an animal. Fixed Blade Broadhead – the blades do not fold away which indicates that they offer greater penetration with a zero chance of blades not expanding. Mechanical Broadhead – such blades are tucked away until they strike a target. It is suggested that without blades sticking out it will fly more like a field point. Considerations when purchasing broadheads are accuracy and sharpness. You would want to choose blades that are as sharp as possible. Als,o choose blades that have similar characteristics to the field points you practice with. For a beginner, a trigger-type release is a preferable option to choose. The wrist strap offers better control and can make drawing the bow easier. Choose a safe option meaning one that takes intentional effort to open and closes when released. You should at the same time be looking for comfort in order not to make it an unpleasant experience. The target itself could become a challenging decision for a beginner. They are either canvas, material filled with enough filling to stop an arrow, or they are made of layered foam. Although bag-style targets are more cost-effective and transportable, they tend to wear out faster and will not stop a broadhead-equipped arrow effectively. The layered foam-style targets are more expensive but will last longer and most of them can be used for broadhead practice too. I found this layered foam target on Amazon that really works well if you are getting started. Although it does seem out of the ordinary to start planning your first hunting trip in the summer, it is for sure the perfect time. Hunting season always comes sooner than expected and it is best to be prepared and ready. Physical preparations do take a while and therefore has to be initiated well in advance. A basic level of physical fitness is required if you are about to take up bow hunting or hunt in a mountainous area where some degree of fitness is a requirement. Even if you only intend on practicing or hunting behind your house a few times, it would really help to be strong and flexible. One option is going for regular workouts but the best preparation is still to get out there and actually do the activities. A few options to consider is to shoot your bow in your backyard. If that is not an option then pay a few visits to any archery in your area. Some people opt to set up a small corner in their garage by using a good backstop and target. Then simply draw your bow back and hold it as long as you can. This will strengthen the appropriate muscles and develop your endurance. Do this several times but be careful not to release the trigger. Bow hunting or archery requires a high level of focus and patience so do not rush it. Once you have practiced this you are ready to actually shoot your bow. In the first few weeks, you should aim to do so a few times each week by shooting 10-12 arrows at a time. A good exercise for endurance is to draw and hold your bow back for up to three minutes before releasing the trigger. We have mentioned working out to exercise specific and much-needed muscles. Do upright and bent-over rows to help build your back and shoulder muscles in a way that’s very similar to actually drawing a bow. Working with front dumbbells: do raises with static holds. Hold a dumbbell-like you would hold the bow in front of you for as long as you can. This will develop your skills of stability when holding the bow. stretch each arm to the left and right, holding it with your other arm for 20 seconds. Then stretch them up high and rotate them down behind you as far as you can. Do a few repetitions of this. Now do some simple shrugs, moving your shoulders in a circular fashion forward and backward. Continue this movement with your arms, circling them around you. Gently pull your head in all directions to loosen your neck muscles. If you can discretely do these in the tree stand when you’re hunting, it will help to keep your muscles flexible and ready. Since bowhunting is a close and personal experience it does take some courage and mental fitness. If you are excited about doing it then you are on your way to becoming a great hunter. If you do experience some doubt and fear then this is perhaps not the right time to be initiating it. Visualization is a superb technique to mentally practice your first shot. It prepares you for the upcoming confrontation. The easiest way to do this exercise is to close your eyes and picture yourself shooting. Do this a few times every night before going to bed. Picture yourself as being in a real hunting situation. Watch and feel how you close the distance and make the shot. Hear the sounds of the leaves under your feet, feel the emotions of seeing the animal walking nearby and imagine the results. This is the most powerful exercise to enhance mental clarity and prepare you for the moment of reality. It is used widely in a variety of different sports. Breathing Control – Breathing is extremely important since the more oxygen you get to your brain and to the muscles, the better your performance will be. It is a natural phenomenon to breathe shallow and hold one’s breath for longer when in stressful situations. This, however, will result in muscle fatigue and poor performance. Practice controlling your breathing by taking in a breath of air with your trigger finger resting on the trigger. As you exhale the air, you slightly hold your breath and begin to squeeze the trigger. Once you are mentally and physically prepared you are ready to buy your field gear. Your Bowhunting clothes should have a proper fit. If clothes are baggy it could send the arrow off target when a released bowstring struck the clothes. It should also be durable since it should last for more than one season. Boots – should be sturdy, broken-in and fit your feet perfectly.

2019-04-25T12:31:47Z

A father purposely drowned his two sons, who both had severe autism, by driving his car off a California pier so he could cash in on a $6 million insurance policy, prosecutors said. Ali Elmezayen, 44, allegedly came up with the pan two years before pressing on the gas of his car and sending it crashing into the Port of Los Angeles on April 9, 2015. The FBI wrote an affidavit in support of Elmezayen’s arrest for insurance fraud last week. Eight-year-old Adbelkarim and 13-year-old Elhassan, who were both severely autistic and couldn’t swim. They were found strapped into their car seats. Elmezayen collected more than $260,000 in insurance payouts for his sons’ deaths and wired more than $170,000 back to his native Egypt, prosecutors said.

2019-04-19T13:17:18Z

As the US unemployment rate rests at a low level not seen since the 1960s, employers are struggling to find qualified candidates to fill many open positions. This is good news for people with disabilities, a population that comprises the largest minority in the country, and yet remains deeply misunderstood and underemployed. The unemployment rate for individuals with disabilities is nearly twice as high as the general worker population: 7.3% versus 3.4% — and remember, those rates just count individuals who are actively looking for work. Employers may be writing off too many strong candidates, with skills and experience needed in today’s workforces, for reasons that aren’t in the résumé. Fortunately, there are ways to benefit from unlocking this hidden talent pool. It just takes a little understanding, awareness and — sometimes — flexibility to find great employees hiding in plain sight. The first step is understanding that there’s no right way for an ideal candidate to “look.” Each applicant has unique strengths and personal qualities that can make him or her a fit for a position. Individuals with disabilities can bring substantial experience with them to a new role. In fact, the majority of people who receive Social Security Disability Insurance have a 22-year work history. This group in particular has an advantage when returning to the hiring pool, as they can access Social Security’s free Ticket to Work program, which helps ease their path back to full employment with supports an employer won’t need to provide. Many work-site accommodations for individuals with disabilities are achievable with little cost or disruption. A disability is simply a set of a few logistical difficulties that can be overcome through the individual’s interest, commitment and, occasionally, creativity. Often, employers can bring their own solutions to the table by making simple accommodations that will help a person with a disability to perform at his or her most productive. Other times, offering the option to work remotely can do the trick. Not every disability will even be obvious. Millions of Americans have unseen medical conditions, such as diabetes, chronic fatigue syndrome, hearing loss, etc., which aren’t readily apparent at first glance. Individuals with these “invisible disabilities” can face criticism and discrimination when people don’t understand they may just need to work in some different ways to succeed. Employers can become powerful allies in changing these paradigms when they hire and accommodate individuals with disabilities in their workplace. Other employees may create their own challenges in working with individuals with disabilities. It’s an unfortunate reality that requires HR to include these employees in its adaptation and engagement process. This is no different from other situations involving employee stereotyping or diversity. A strong interview process is especially important. One of the best ways to avoid discomfort for you and applicants during the interview process is to focus on what really matters: their qualifications and experience for the job. This way, you’ll be giving all the potential employees in your hiring pool a level playing field. Multiple meetings may also give your team more opportunities to begin to feel comfortable with someone whose disability will quickly fade into the background once they’re part of the team. Each of us, no matter our ability level, has personal struggles and challenges in our daily lives, such as troubles with children or a spouse, an illness of a parent, or other serious issues. Candidates and employees with disabilities are no different. It’s important to get to know these people as individuals in order to determine specific needs and requirements. While it will take some work on the part of the HR and management teams, the benefit is obvious: hiring great employees that others may be dismissing. Paula Morgan is is a return to work case manager for Allsup Employment Services, a national, SSA-authorized employment network.

2019-04-26T06:53:55Z

The size charts we provide are recommended guidelines. So even though you may think you've measured exactly as our instructions say, your support may not fit properly (for a variety of reasons). Please examine your purchase carefully upon receipt. We take pride in our quality control, but if a product is found factory defective, please call us immediately to arrange for replacement. Defects and damage to goods caused by improper care and application will NOT be accepted for return. As with any fabric or material, the color of the products may vary slightly due to material type or dye lot. This is NOT considered a product defect and our return policies will still apply. ALL RETURN/EXCHANGE ITEMS MUST BE CLEAN OR THEY WILL NOT BE ACCEPTED! To qualify you must: Contact us within 5 business days of the arrival of your product. The product must be in unworn condition in original packaging and unsoiled. Product must be returned within three weeks. Custom made items, (including custom colors) are non returnable – non refundable. These items are made specifically to your provided measurements and/or specifications and cannot be restocked. If you think your custom sleeve may be defective, call for a return authorization so that we may inspect the item; if a defect is determined your custom will be replaced at no additional charge. 1. You contact us to inform us you'll be sending your item back and tell us which size you'd like to try instead. We wait until we receive the item from you, and then we send out the new size you've chosen. You must pay to mail the incorrectly sized items back, and we'll send the second item back without charging a restocking fee, the only cost is the shipping/handling. 2. When you need the new size sent in a hurry, we can send out the new size right away, but you would have to pay for the product plus shipping/handling again (basically a new order is placed), and we would credit back the original order you placed minus the shipping/handling costs when we receive the original item that you have mailed back to us (Again there's no restocking fee). * Call for Return Authorization Number within 5 business days. * Product must be in unworn condition in original packaging and unsoiled. * Product must be returned to us within 15 business days of the day you call for a return authorization number. Items returned unclean or without prior authorization will be sent back at the customers’ expense. There are absolutely NO refunds on shipping charges or custom ordered products!!!!

2019-04-25T08:11:45Z

Follow in the time-travelling footsteps of the lead characters and visit the locations that inspired the novels and were used in the filming of this historical romance. The first series of Outlander follows the Jacobite Rising of 1745 (often known as the ’45), culminating in the historic Battle of Culloden. Culloden features in both timelines of the story: first in 1946 when Frank and Claire visit the battlefield to research Frank’s family history; and secondly in 1746 when a pregnant Claire revisits the field with Jamie ahead of the battle – her knowledge of the impending massacre forces them to part and she returns to the 20th century. Filming took place in Falkland village in October 2013. The village, home to Falkland Palace, is re-cast as 1946 Inverness, where Claire and Frank stay on their second honeymoon. While researching Frank’s ancestral history, Claire and Frank secretly watch a pagan ceremony at standing stones on a nearby hill. Claire is fascinated by this ritual. She returns alone to the stones and falls through time to 1743. Other featured locations in Falkland include The Covenanter Hotel as Mrs Baird’s guesthouse; the Bruce Fountain, where the ghost of Jamie looks up at Claire’s room; Lomond Pharmacy which doubles as Campbell’s Coffee Shop; and Fayre Earth Gift Shop as Farrell’s Hardware and Furniture Store, where Claire stops to look at a vase in the window. Culross Palace, Garden and Royal Burgh feature in a number of scenes filmed between late 2013 and summer 2014. The Royal Burgh acts as the fictional village of Cranesmuir, where Geillis Duncan lives with her husband, the procurator fiscal. Geillis and Claire share an interest in the healing qualities of plants and herbs, although Geillis’s interests have a much darker side. Claire and Geillis are marched through the streets of Cranesmuir when suspected of witchcraft. The Mercat Cross underwent a temporary colour change from white for filming, to match the surrounding buildings that were painted grey and brown. It features in the dramatic scene where a small boy has his ear pinned to the post, having been caught stealing; while Claire creates a distraction, Jamie sets him free. Culross Palace’s Withdrawing Room doubles as Geillis’ parlour, where Jamie comes to meet Claire after her visit to Geillis. The palace garden features as the herb garden of Castle Leoch, where Claire collects plants for medicinal use. Filming took place at Preston Mill in May 2014. The location features as the mill on the Fraser estate (Lallybroch) that Jamie goes to repair while visiting his family home. When Redcoats arrive unexpectedly, Jamie hides underwater as Claire and his sister try to distract them. The Mill’s exhibition room was transformed into the ante-room at the court, used for the preliminary hearing of Claire and Geillis when they are accused of witchcraft. The following locations have strong ties to the Jacobite period and inspired the Outlander story. Newly released images show the extent of water damage at the Hill House.

2019-04-21T00:44:44Z

Designed with a modern high-rise fit, Tess is a super-skinny style that fits slim throughout the hip, thigh, and leg opening for a flattering shape. Made in our lightly-faded black wash, these have a rich, smoky colour. This pair is cropped above the ankle with fringe hem for a vintage look in a modern silhouette.

2019-04-19T03:07:39Z

oin us at Las Cruces UkeFest 2018 May 18 – 20 for a concert, workshops, jam session, open mic, and more with our instructor/performers Craig Chee, Sarah Maisel, Mark Baker, Lil’ Rev, and Rachel Manke. As an incentive to register at the discounted Early Bird rate, one lucky person who registers for the full festival by that deadline that will win the opportunity to perform on stage with Lil’ Rev during our Friday night concert! Go to the Register page to link to Brown Paper Tickets and sign up now. Don’t miss a great weekend of ukulele fun!

2019-04-20T06:50:16Z

Shall We Leave It to the Experts? India lives in several centuries at the same time. Somehow we manage to progress and regress simultaneously. As a nation we age by pushing outward from the middle--adding a few centuries on either end of the extraordinary CV. We greaten like the maturing head of a hammerhead shark with eyes looking in diametrically opposite directions. I don't mean to put a simplistic value judgment on this peculiar form of "progress" by suggesting that Modern is Good and Traditional is Bad--or vice versa. What's hard to reconcile oneself to, both personally and politically, is the schizophrenic nature of it. That applies not just to the ancient/modern conundrum but to the utter illogic of what appears to be the current national enterprise. In the lane behind my house, every night I walk past road gangs of emaciated laborers digging a trench to lay fiber-optic cables to speed up our digital revolution. In the bitter winter cold, they work by the light of a few candles. It's as though the people of India have been rounded up and loaded onto two convoys of trucks (a huge big one and a tiny little one) that have set off resolutely in opposite directions. The tiny convoy is on its way to a glittering destination somewhere near the top of the world. The other convoy just melts into the darkness and disappears. A cursory survey that tallies the caste, class and religion of who gets to be on which convoy would make a good Lazy Person's concise Guide to the History of India. For some of us, life in India is like being suspended between two of the trucks, one leg in each convoy, and being neatly dismembered as they move apart, not bodily, but emotionally and intellectually. Fifty years after independence, India is still struggling with the legacy of colonialism, still flinching from the "cultural insult." As citizens we're still caught up in the business of "disproving" the white world's definition of us. Intellectually and emotionally, we have just begun to grapple with communal and caste politics that threaten to tear our society apart. But meanwhile, something new looms on our horizon. On the face of it, it's just ordinary, day-to-day business. It lacks the drama, the large-format, epic magnificence of war or genocide or famine. It's dull in comparison. It makes bad TV. It has to do with boring things like jobs, money, water supply, electricity, irrigation. But it also has to do with a process of barbaric dispossession on a scale that has few parallels in history. You may have guessed by now that I'm talking about the modern version of globalization. What is globalization? Who is it for? What is it going to do to a country like India, in which social inequality has been institutionalized in the caste system for centuries? A country in which 700 million people live in rural areas. In which 80 percent of the landholdings are small farms. In which 300 million people are illiterate. Is the corporatization and globalization of agriculture, water supply, electricity and essential commodities going to pull India out of the stagnant morass of poverty, illiteracy and religious bigotry? Is the dismantling and auctioning off of elaborate public sector infrastructure, developed with public money over the past fifty years, really the way forward? Is globalization going to close the gap between the privileged and the underprivileged, between the upper castes and the lower castes, between the educated and the illiterate? Or is it going to give those who already have a centuries-old head start a friendly helping hand? Is globalization about "eradication of world poverty," or is it a mutant variety of colonialism, remote-controlled and digitally operated? These are huge, contentious questions. The answers vary depending on whether they come from the villages and fields of rural India, from the slums and shantytowns of urban India, from the living rooms of the burgeoning middle class or from the boardrooms of the big business houses. Today India produces more milk, more sugar and more food grain than ever before. And yet, in March 2000, just before President Clinton's visit to India, the Indian government lifted import restrictions on 1,400 commodities, including milk, grain, sugar, cotton, tea, coffee and palm oil. This despite the fact that there was a glut of these products on the market. Developed countries like the United States, whose hugely subsidized farm industry engages only 2 to 3 percent of its total population, are using the WTO to pressure countries like India to drop agricultural subsidies in order to make the market "competitive." Huge, mechanized corporate enterprises working thousands of acres of farmland want to compete with impoverished subsistence farmers who own a couple of acres. In effect, India's rural economy, which supports 700 million people, is being garroted. Farmers who produce too much are in distress, farmers who produce too little are in distress and landless agricultural laborers are out of work as big estates and farms lay off their workers. They're all flocking to the cities in search of employment. "Trade Not Aid" is the rallying cry of the head men of the new Global Village, headquartered in the shining offices of the WTO. Our British colonizers stepped onto our shores a few centuries ago disguised as traders. We all remember the East India Company. This time around, the colonizer doesn't even need a token white presence in the colonies. The CEOs and their men don't need to go to the trouble of tramping through the tropics, risking malaria, diarrhea, sunstroke and an early death. They don't have to maintain an army or a police force, or worry about insurrections and mutinies. They can have their colonies and an easy conscience. "Creating a good investment climate" is the new euphemism for Third World repression. Besides, the responsibility for implementation rests with the local administration. The fishbowl of the drive to privatize power, its truly star turn, is the story of Enron, the Houston-based natural gas company. The Enron project was the first private power project in India. The Power Purchase Agreement between Enron and the Congress Party-ruled state government of Maharashtra for a 740-megawatt power plant was signed in 1993. The opposition parties, the Hindu nationalist Bharatiya Janata Party (BJP) and the Shiv Sena, set up a howl of swadeshi (nationalist) protest and filed legal proceedings against Enron and the state government. They alleged malfeasance and corruption at the highest level. A year later, when state elections were announced, it was the only campaign issue of the BJP-Shiv Sena alliance. In February 1995 this combine won the elections. True to their word, they "scrapped" the project. In a savage, fiery statement, the opposition leader L.K. Advani attacked the phenomenon he called "loot through liberalization." He more or less directly accused the Congress Party government of having taken a $13 million bribe from Enron. Enron had made no secret of the fact that in order to secure the deal, it paid out millions of dollars to "educate" the politicians and bureaucrats involved in the deal. Following annulment of the contract, the US government began to pressure the Maharashtra government. US Ambassador Frank Wisner made several statements deploring the cancellation. (Soon after he completed his term as ambassador, he joined Enron as a director.) In November 1995 the BJP-Shiv Sena government in Maharashtra announced a "renegotiation" committee. In May 1996 a minority federal government headed by the BJP was sworn in at New Delhi. It lasted for exactly thirteen days and then resigned before facing a no-confidence vote in Parliament. On its last day in office, even as the motion of no confidence was in progress, the Cabinet met for a hurried "lunch" and reratified the national government's counterguarantee (which had become void because of the earlier "canceled" contract with Enron). In August 1996 the government of Maharashtra signed a fresh contract with Enron on terms that would astound the most hard-boiled cynic. The impugned contract had involved annual payments to Enron of $430 million for Phase I of the project (740 megawatts), with Phase II (1,624 megawatts) being optional. The "renegotiated" power purchase agreement makes Phase II of the project mandatory and legally binds the Maharashtra State Electricity Board (MSEB) to pay Enron the sum of $30 billion! It constitutes the largest contract ever signed in the history of India. Indian experts who have studied the project have called it the most massive fraud in the country's history. The project's gross profits work out to between $12 billion and $14 billion. The official return on equity is more than 30 percent. That's almost double what Indian law and statutes permit in power projects. In effect, for an 18 percent increase in installed capacity, the MSEB has to set aside 70 percent of its revenue to pay Enron. There is, of course, no record of what mathematical formula was used to "re-educate" the new government. Nor any trace of how much trickled up or down or sideways or to whom. But there's more: In one of the most extraordinary decisions in its not entirely pristine history, in May 1997 the Supreme Court of India refused to entertain an appeal against Enron. Today, everything that critics of the project predicted has come true with an eerie vengeance. The power that the Enron plant produces is twice as expensive as its nearest competitor and seven times as expensive as the cheapest electricity available in Maharashtra. In May 2000 the Maharashtra Electricity Regulatory Committee (MERC) ruled that temporarily, until as long as was absolutely necessary, no power should be bought from Enron. This was based on a calculation that it would be cheaper to just pay Enron the mandatory fixed charges for the maintenance and administration of the plant that it is contractually obliged to pay than to actually buy any of its exorbitant power. The fixed charges alone work out to around $220 million a year for Phase I of the project. Phase II will be nearly twice the amount. Two hundred and twenty million dollars a year for the next twenty years. Meanwhile, industrialists in Maharashtra have begun to generate their own power at a much cheaper rate, with private generators. The demand for power from the industrial sector has begun to decline rapidly. The MSEB, strapped for cash, with Enron hanging like an albatross around its neck, will now have no choice but to make private generators illegal. That's the only way that industrialists can be coerced into buying Enron's exorbitantly priced electricity. In January 2001 the Maharashtra government (the Congress Party is back in power with a new chief minister) announced that it did not have the money to pay Enron's bills. On January 31, only five days after an earthquake in the neighboring state of Gujarat, at a time when the country was still reeling from the disaster, the newspapers announced that Enron had decided to invoke the counterguarantee and that if the government did not come up with the cash, it would have to auction the government properties named as collateral security in the contract. But Enron had friends in high places. It was one of the biggest corporate contributors to President George W. Bush's election campaign. US government officials warned India about vitiating the "investment climate" and running the risk of frightening away future investors. In other words: Allow us to rob you blind, or else we'll go away. Last June the MSEB announced that it was ending its agreement with the Dabhol Power Corporation, a joint venture of Enron--which has the largest stake--General Electric and Bechtel. DPC ceased operations soon afterward, and is pressuring the government to cover its debts. Royal Dutch/Shell, the Anglo-Dutch petroleum group, TotalFinaElf and Gaz de France are currently bidding to take over Enron, Bechtel and GE's collective stake in the plant in a "distress sale." Recently, globalization has come in for some criticism. The protests in Seattle and Prague will go down in history. Each time the WTO or the World Economic Forum wants to have a meeting, ministers have to barricade themselves with thousands of heavily armed police. Still, all its admirers, from Bill Clinton, Kofi Annan and A.B. Vajpayee (the Indian Prime Minister) to the cheering brokers in the stalls, continue to say the same lofty things: If we have the right institutions of governance in place--effective courts, good laws, honest politicians, participatory democracy, a transparent administration that respects human rights and gives people a say in decisions that affect their lives--then the globalization project will work for the poor as well. They call this "globalization with a human face." The point is, if all this were in place, almost anything would succeed: socialism, capitalism, you name it. Everything works in Paradise, a Communist State as well as a Military Dictatorship. But in an imperfect world, is it globalization that's going to bring us all this bounty? Is that what's happening in India now that it's on the fast track to the free market? Does any one thing on that lofty list apply to life in India today? Are state institutions transparent? Have people had a say--have they even been informed, let alone consulted--about decisions that vitally affect their lives? And are Clinton (or now Bush) and Prime Minister Vajpayee doing everything in their power to see that the "right institutions of governance" are in place? Or are they involved in exactly the opposite enterprise? Do they mean something else altogether when they talk of the "right institutions of governance"? The fact is that what's happening in India today is not a "problem," and the issues that some of us are raising are not "causes." They are huge political and social upheavals that are convulsing the nation. One is not involved by virtue of being a writer or activist. One is involved because one is a human being. If you're one of the lucky people with a berth booked on the small convoy, then Leaving It to the Experts is, or can be, a mutually beneficial proposition for both the expert and yourself. It's a convenient way of shrugging off your own role in the circuitry. And it creates a huge professional market for all kinds of "expertise." There's a whole ugly universe waiting to be explored there. This is not at all to suggest that all consultants are racketeers or that expertise is unnecessary, but you've heard the saying: There's a lot of money in poverty. There are plenty of ethical questions to be asked of those who make a professional living off their expertise in poverty and despair. For instance, at what point does a scholar stop being a scholar and become a parasite who feeds off despair and dispossession? Does the source of your funding compromise your scholarship? We know, after all, that World Bank studies are among the most quoted studies in the world. Is the World Bank a dispassionate observer of the global situation? Are the studies it funds entirely devoid of self-interest? Take, for example, the international dam industry. It's worth $32-$46 billion a year. It's bursting with experts and consultants. Given the number of studies, reports, books, PhDs, grants, loans, consultancies, environmental impact assessments--it's odd, wouldn't you say, that there is no really reliable estimate of how many people have been displaced by big dams in India? That there is no estimate for exactly what the contribution of big dams has been to overall food production in India? That there hasn't been an official audit, a comprehensive, honest, thoughtful, post-project evaluation, of a single big dam to see whether or not it has achieved what it set out to achieve? Whether or not the costs were justified, or even what the costs actually were? Cynics say that real life is a choice between the failed revolution and the shabby deal. I don't know...maybe they're right. But even they should know that there's no limit to just how shabby that shabby deal can be. What we need to search for and find, what we need to hone and perfect into a magnificent, shining thing, is a new kind of politics. Not the politics of governance, but the politics of resistance. The politics of opposition. The politics of forcing accountability. The politics of slowing things down. The politics of joining hands across the world and preventing certain destruction. In the present circumstances, I'd say that the only thing worth globalizing is dissent. It's India's best export. © 2002 The Nation Company, L.P. Arundhati Roy was born in 1959 in Shillong, India. She studied architecture in New Delhi, where she now lives, and has worked as a film designer, actor, and screenplay writer in India. Her latest book, Listening to Grasshoppers: Fields Notes on Democracy, is a collection of recent essays. A tenth anniversary edition of her novel, The God of Small Things (Random House), for which she received the 1997 Booker Prize, was recently released. She is also the author of numerous nonfiction titles, including An Ordinary Person's Guide to Empire.

2019-04-22T10:45:58Z

I always loved to write. When I was a kid I won awards at school for writing short stories, poems, I even got one of my stories published in a book. I did an admission exam for one of the best universities in Brazil and I got a 10 (the highest score in the Brazilian grading system) in my essay. I love the Portuguese language and literature. I was always excellent in interpreting what writers meant. I wanted to be a journalist. I was sure that putting words in a piece of paper (even if the paper is virtual) would be my livelihood. But I changed my mind and I studied Media Studies. And I moved out of Brazil. I chose to live in a different country. Don’t get me wrong, I am very happy with my life but communicating, and telling stories is a very important part of who I am and sometimes I feel that it is suppressed for my insecurities regarding the language. Now that I am concluding my Masters in Content Strategy in German and English at the University of Applied Sciences FH Joanneum in Austria, sometimes it feels very frustrating in the writing part, honestly. I learned what are the best techniques for writing, how long a title should be, how the texts should be structured for better readability but I don’t write for a living anymore. When I write a blog post now it feels like homework. Because it is. I plan the whole blog post in my mind. I know where it will take. There are no surprises, no twists. And then I start writing. Title (with maximal 12 words), teaser, picture, paragraph, h1, bullet list, h2, conclusion… The process of writing now it is not easy and not hard, is just another task I have to finish. I don’t hate it and I don’t love it, I just want to be done with it. I really hope that someday I can have the confidence and the motivation to write blog posts in other languages as much as I do in Portuguese.

2019-04-19T18:58:42Z

What is A Media Production Company? Media production companies in Dubai deliver things, for example, advertisements, films, short documentaries, audio clips and recordings in different TV and Internet patterns. This profession may include working with others to choose a video point, content composition, set building and throwing notwithstanding planning studio time and other booking concerns. Media creation masters may pick titles, music, liveliness and portrayal; alter and orchestrate video; and create program material that could be aired online or on the TV channels. They may require skill with PC programming altering projects and video hardware, for example, cameras, amplifiers and lighting. Programming to ace may incorporate Final Cut Pro, AVID, AfterEffects and Photoshop. Computerized and online media occupations have turned out to be more pervasive as of late as the Internet and Web-based media work has expanded. Media creation pros ought to take after improvements in the media generation industry and might be called upon to make suggestions for obtaining new hardware. Trying media generation authorities may contemplate propelled sound and video creation aptitudes, mass correspondence rehearses, film history, Internet programming, narrative generation and movie creation. An arrangement of work may help yearning media generation masters find occupations. Understudies may work at school TV and radio stations to pick up involvement. The rivalry is serious since many wish to work in movies and broadcasting-related fields. A four-year college education is regularly the base instructive prerequisite, as per the BLS, or U.S Bureau of Labor Statistics. Courses may incorporate film investigation, video creation and new media hypothesis. As indicated by the BLS, film and video editors, who are like media creation experts in Media production companies in Dubai, made a middle wage of $61,750 every year in May 2015. The normal time-based compensation was $38.61. Those in the last 10% earned $26,270 or less, while film and video editors in the best paid 10% made $155,840 or more, the BLS said. There were around 27,660 individuals acting as film and video editors broadly, in spite of the fact that this gauge did exclude independently employed and independent labourers in this field. Work for film and video editors was relied upon to develop by around eighteen percent from 2014 until 2024, the BLS noted. Media generation pros have parts like film and video editors- – they might be associated with picking a theme for a video, picking or composing contents and titles, picking a cast or music, altering film and different concerns identified with creation. They deliver sound and video content that could be utilized for ads or films. These experts must have the right stuff to utilize PC programming and video hardware. A four-year college education program gives the chance to ponder significant points. Yes, you have read it right. There are many different types of production companies in Dubai. For example, Meraki is also one of them that is based on a group of mature filmmakers and producers. If we talk about various production houses in Dubai that you will come to know that Film creation organizations can be organized in various ways, generally dictated by money-related conditions. Numerous new companies can’t die down on their “in-house” imaginative tasks alone, in any event at the outset, and rely upon offering content, generation, and after creation administrations to business and corporate customers. This is what number of movie producers start, regularly working out of their home with constrained assets. For example, a Meraki production company in Dubai was not started in all of a sudden with a group of professionals. In fact, this company was first started by a single man who was working as a one-man army and then with the passage of the time, his work started expanding in Dubai and look this company has now changed the entire face of the media production companies in Dubai. There is no compelling reason to legitimize a production company on the off chance that it is a sole proprietorship bearing your name (e.g., Ali Doe and Associates or Jane Smith Productions), yet in the event that you utilize an imaginary name you should experience a straightforward enrollment and declaration process that is offered by most neighborhood daily papers. For example, we can have an example of Meraki production, this name does not come from the name of the owner of the company. As we have had discussed this myth earlier, this names comes from the Greek word that means something that is being done with hard work and passion. In this circumstance, at least two inventive personalities meet up to frame an organization. An understanding ought to be marked between the accomplices to evade suspicions about parts and duties. We can take the example of Meraki again because with the passage of the time their production company was turned into a successful production company in Dubai. Now and then movie producers shape a transient organization, for example, a constrained association, with the objective of finishing a particular autonomous film venture, which is essential when working with speculators. A meraki production company in Dubai is not a task specific company because they provide their services for various types of the productions. With accounts out of the door or worked after some time, some film creation organizations can offer a full cluster of administrations, from scripting and generation to post. Thusly, they normally frame a kind of enterprise. These organizations, for the most part, make their benefits on customer administrations to help counterbalance the overhead of hardware and staffing. Again we have an example of Meraki productions that is a complete packet of scriptwriters, producers, filmmakers, production marketers and even editors. On the off chance that you have ever needed the key to making your own particular film, here it is: Meraki production company is Dubai would your best choice because they past experience with filmmaking has been astonishing. Their videos and movies have always touched the limits of the skies. Dubai is a wonderful place to live a luxury life where people expect a high quality of fashion to be displayed to them. This can’t be done without having some professional photographers in Dubai and luckily Dubai has always been a heaven for fashion photographers. The beautiful models of Dubai would have been of no use without these talented fashion photographers (photographers are yet to be discussed). These capable men and ladies are particularly alluring, as they have devoted their lives to breathing life into the mold. They change models into charming and persevering pictures that move the world to be a more excellent place. Their work is legendary to the point that it’s each form display dream to gain a place in their portfolios. Who is Best Fashion Photographer in Dubai? Without any doubt, Mazen Abusrour is considered as one of the best fashion photographers in Dubai. He lies at the top of the professional photographers in Dubai. Mazen was born in Jordan and he left his educations and country to get what he had always dreamed. Mazen Believes that he was not a born photographer, in fact, when he took few clicks with his phone camera and people praised those photos pushed him to carry this field as his profession. People use cameras to captures pictures but he captures feelings and his own ideas into his lenses. I would rather call him most talented and creative fashion photographer in Dubai. Once he was asked about his any regrets about quitting his education for his photography passion and his response was like, “No! I have no regrets regarding my educations or other dreams because I just love what I do”. As you know, Mazen Abusrour is known as the best fashion photographer in Dubai but have you ever wondered what made him such an excellent photographer? You will be amazed to know that he does like shooting in studios because he believes that real natural beauty can’t be captured while sitting in the studio. That is the reason why his most of fashion shoots are done outdoor that only represent the pretty models but also captures the natural scenes. Passion, love, grace, creativity and resources are the elements that make an ordinary man the best photographer in Dubai. Most of the photographers rely on the models they are shooting with but this guy relies on backgrounds and locations even more than models he is working with. So, we were talking about his photography career. Actually, years ago he too few pictures from his mobile phone camera and after he got some exceptional reviews from his friends and internet users, he decided to take this photography to a whole new level. People are tired of seeing perfectly fake models and photoshoots and that is the reason why he tries to give a look of real natural taste in his photoshoots. According to him, people are just crazy for seeing perfection and that is the reason why sometimes photographers rely on fake visual effects but he is totally against it. He finds imperfections in his shots and then makes them perfect with beautiful ideas and suitable angles. We are living in a world where it is thought that you should have a camera with very big and expensive lenses to become a professional fashion photographer but Mazen proved them wrong with his passion and commitment. You will often see this guy without his huge lenses and taking pictures of models with a smartphone and yet his clicks hit the hearts of the fashion industry. He believes that you should have the art of taking pictures and you don’t need expensive gadgets to show what you are. Photography is not about carrying heavy and precious cameras but it is all about having skills and passion for your work. According to him, you have to (being a cameraman) leave your pictures for people to interpret their quality and idea. A picture can’t always speak, sometimes viewers should observe and then decide. He believes, in self-representation and this what makes him the best fashion photographer in Dubai. Sometimes he portrays himself in his pictures and then leaves rest to the people to decide the quality of his pictures. According to him, if you like his picture work then it means indirectly you like him. Sometimes pictures that you see are self-explanatory and you don’t need to think so hard to get to know about the reason behind the picture. Mazen Abusrour believes that technology around us is very advanced but still this technology can’t give you the emotions and feelings. These emotions and feelings are portrayed by the models and then sensibly captured by the best photographers in Dubai. He so lucky because he is doing what he loves or in other words, he is earning money from his hobby. He started photography as a hobby and with the passage of time, his passion started helping him earn money by taking super shots of supermodels in Dubai. Very few people know that he is a multi talented graphics artist. Mazen is a graphics motion artist and initially, he was planning to start his career with these motion graphics. He was working with videos and after reaching a certain level of success in motion graphics he decided to jump into Dubai fashion industry and currently he stands amount the best fashion photographers in Dubai. So, he left his video motions years ago and started focusing on only one focal point that was photography. There are many professional photographers in Dubai and Mazen Absrour is one of them. In short, this guy likes transforming pictures into emotions and they portraying them inform of the public with a new creative idea and thought. Media Production companies in Dubai have been participating in the entertainment and advertisement industry of Dubai from last one decade. Other than film production companies in Dubai many outsiders have also been playing an active role to shoot their major films in the country. In those foreign countries, Hollywood, Bollywood and Lollywood lie on the top of the list. Today we are going to discuss top five Hollywood movies that were filmed on the major location of beautiful Dubai. I personally loved many shots of this movie that were filmed on Burj Khalifa. The scenes in the movie were so realistic and can even make you feel scared. Do you remember the scene where the protagonist of the movie climbs of sky touching building of the Burj Khalifa with the help you his magic gloves? This scene was actually filmed on the real building where almost 400 crew members were there just to make sure the safety of the climber. Who can forget shooting of Fast and Furious 7 in Dubai? Which stunned the film production companies in Dubai for a while. Though these scenes were not filmed on the major locations of the city and most of them were shot in the sandy deserts of the Dubai. Media production companies in Dubai did love this new innovation in the city and we hope to see some more work from foreigners in Dubai. This movie revolves around a CIA agent who is in Dubai. Shots of that major CIA agent were mostly shot in Dubai, in hotels and restaurants. This movie did inspire many filmmakers from all across the globe to shoot their new movies in the beautiful location of Dubai. The continuation of the 1987 film, Wall Street, gazing Michael Douglas and Shia La Beouf, is the tale of an ex-conman and convict attempting to develop his realm by and by while attempting to reconnect with his girl. The majority of the motion picture focuses on naughty characters doing devious things yet we likewise get a look at the marvellous life the heroes lead. As anyone might expect, they picked Dubai for the lavish shots. Who imagined that the love of the youth the Star Wars movie was also shot in Dubai. Film production companies in Dubai also helped in the shooting of Dubai shots. The hotly anticipated Episode VII of the Star Wars establishment is now out in the cinemas. Taping started in April a year ago and cast individuals set out to Abu Dhabi toward the beginning of May, where monstrous sets were worked at the area. The set incorporated a bus like a shuttle, an extensive pinnacle and a major market. Look at more Star Wars pics here and yet another example of Hollywood movie in Dubai. Media production companies in Dubai are also planning to start their new projects on the major location of Dubai like Burj Khalifa, deserts and on beaches. A production house is not less than an entertainment club where different ideas are expressed into realities. A production house is a place from where new talents and investments emerge into the markets. A production company in Dubai is a place from where new entertainment, informative and much more similar stuff comes out. In simpler words, production companies are main producers of new songs, fashion shows, entertainment videos and even serials. These production companies either invest to produce and hire new talents or operate on the external investments. Another form of production companies is they are hired by the people to get different production tasks done. Dubai has always been a heaven for production companies where different opportunities keep popping up for the actors, directors and producers. As I always say, Dubai is a place of dreams, in fact, where all dreams come true. Video production companies in Dubai are making millions of dollars on a monthly basis and of course, why shouldn’t they? Dubai is a city of technology and modern people where needs of new advertisements of technical equipment, products and eatables arise every day. What is Video Production All About? You may believe that creating a video narrative does not require a content. Of course, you can go out and shoot heaps of film and return to the altering room and sort video cuts out and makes a rational story. It’s a great deal less demanding on the off chance that you, in any event, set up together a framework for your film ahead of time. That diagram is your content. These components assume a part of the pre-generation and composing process. Some portion of what is interesting about narrative film generation is that such an extensive amount it isn’t scripted. You can’t constrain somebody to state precisely what you need. In the event that you do, you are currently making ads or motion pictures. Your examination should lead you to comprehend that a specific interviewee may have endured an awesome misfortune and you need to have them disclose to you, in their own particular words, how that misfortune influenced them and their family. You can get the embodiment of what you are searching for by asking the correct inquiries amid the meeting. You can lead your subject along these lines, however, at last, they will portray their circumstance in their own particular words. Having a “pre-shoot” content will enable you to get and no more important certainties and stories that you have to display the master plan you are endeavoring to pass on. Meraki Production starts with arranging stage. There will be no account amid this procedure, just arrangement. Everything is sorted out in an arrangement for the accounting procedure. Scene areas are chosen, the content is altered and reconsidered if essential, and a framework of the whole account process is made. There are numerous extra factors that must be audited too. Appropriate lighting for every scene is basic. Daylight and manufactured lighting don’t frequently blend well, so the season of day, climate conditions, and area for every scene must be deliberately picked. When all the cast and team have been procured by Meraki Productions, and the content has been altered and endorsed, the real creation process can start. Group and cast individuals all movement to every area, and every scene is shot to the point that it is attractive. At that point, everybody will move to the following scene. This procedure rehashes until the point when each scene in the film has been shot. Once every scene has been legitimately shot, it’s an ideal opportunity to proceed onward to the following phase of after creation. The real game starts after the production when Meraki Production covers all activities that are performed after the real shooting of the film has been finished. This incorporates consolidating every scene, synchronizing sound and video, altering sound and video, and including embellishments. As mentioned earlier, there are numerous organizations that offer video creation as an administration but quality work of Meraki productions is outclass and of the top level. This permits organizations and people that don’t have any film-making background to make advertising recordings or different business-related recordings to improve their organization picture and feature their items and administrations. For video creation to be fruitful, there must be considerably more behind it than only a person with a camera. The video must be focused on and conveyed effectively, or the video will just achieve few potential clients. A video portraying a general diagram of your items as well as administrations is extraordinary on the off chance that you have an emerging specialty, however in the event that you have a rivalry, your video must demonstrate the potential client why they ought to pick your organization over your rival’s organization. Hence, you may accomplish better outcomes by making a few short recordings, each focused at a particular statistic. The recordings would then be able to be dispersed through the right stages to achieve the greatest number of individuals who might be occupied with your organization’s administrations. Do you have an impression and that everyone is in photo and video production nowadays? If you are organizing essential family events, or you need this service for business, then finding the right partner in this project is a crucial thing. Unfortunately, many companies often promise the services which they can’t deliver, so finding the right one can be a bit of a challenge. We have a couple of strategies for you which will help you choose the best company on the market and save you are a lot of time and effort. You shouldn’t make video or photo session just because it’s trendy now. Instead of this, think about the things your recordings can achieve. Is it your goal to increase your business, to educate your clients, or to create a beautiful personal footage that will last you for life and become stunning memories. First of all, you should determine your goal and then work with the companies which be able to recognize the understand your ideas. If it’s possible, present them your requirements and then see how they will react. A lot of productions companies will promise the results they can’t deliver. Many clients don’t know the difference between quality materials and armature one and this is why some prices seem too good to be true. The most expensive thing that can happen is to repeat this entire process all over again. In this case, you are required to find out what’s included in the package and are edits involved. You should make sure to pay attention to any additional costs because, in the end, you can burst your budget. Some production companies will promise various things only to land a client and then under – deliver when they finish the project. When you are hiring a production business, make sure to specify the deadline. Also, they should guarantee you that dedicated team of professionals will be working on your project, especially if you are creating it for your company. In this case, you need to look presentable because the future of your business will depend on the success of production company. You should research the web and find the company that has a lot of satisfied clients and excellent review rate. Otherwise, don’t bother because the whole project will be doomed. Whether you are organizing a wedding, or birthday party, or corporate event, you need to find the professionals who are designated to perform such business. It is essential to find personnel who has experience in particular projects because they have an eye for details you might miss. Before hiring them, don’t forget to ask for sample videos and photos, as well as references from the previous clients. The connection they have with their customers will help you determine the level of expertise they have and how they behave in certain situations. If you are in need of video or photography production, then It’s time to start looking for a business that will meet your needs. Depending on your requirements, you might think that hiring some other service might be cheaper, but the quality can’t be compared. On the other hand, a professional company will save you a lot of time, effort, and money, but at the same time, you will get a high – quality material. So, here are a couple of reasons why you should hire the professional services. Experienced professionals can make everything look so easy, so you might think that making excellent photos and videos is a natural thing, but the reality is entirely different. Once you start doing some job you aren’t skilled at, you will realize the value of professional help. In most cases, photo and video production companies are staffed by individuals who are educated and have an extensive experience and they have knowledge of how to achieve the requested result. The quality of the footage and recordings largely depends on the equipment you are using, and no amount of post-production work can remedy mistakes you have made. Imagine you have organized everything for a massive celebration and smile mistake like hiring an amateur, can ruin everything. You will want to create the memories that will last you for life. Professional companies have spent thousands of dollars on an expensive equipment and for a reason, to provide their clients a unique experience. The best thing about everything, educated individuals know how to use the equipment and achieve the high – quality and the best effect. You can always rent the equipment, but no one can guarantee you the results. In some case, it isn’t always about the tools and raw footage you have; it is also about this entire process of making the quality material. A professional photo and video production company has the whole system in place and knows how to realize the project from the beginning until the end. They are also aware of the steps, photos and video projects require project management and time management skills, which are learned through many years of experience. Many do it yourself projects usually take longer because you don’t feel the pressure. On the other hand, the company you have hired will deliver everything on time and without delay. This is very important if you are organizing some celebrations of corporate events. Even though you might think you will save a lot of money by doing everything on your own, but that’s not the case with this one. You will waste a valuable time which you can use for other things. Companies that are in this business know the real value of every video or photo session they produce, so there is no need in jumping ahead with predictions. Just send them an inquiry and present them your ideas and they will give you the estimate of costs.

2019-04-24T00:11:24Z

← JPFmovies’ next foray into the Sci-Fi world: Star Trek Enterprise (2001-2005). Almost everyone complained about it but we didn’t think it was bad. I met Janeway once. That woman rocks. But my gf says Bellana and Seven steal a lot of the shows. And the Doctor. I used to think the only Doctor was Doctor Who. You met Janeway huh–Jude you may want to lay off the sauce for a little while. Voyager was easily the worst of the Franchises. If not for 7 of 9 no-one would remember it. Sorry but Kate Mulgrew was woeful. Didn’t know when to be strong and didn’t know when to be supportive. Agree on Bellana and the Doctor as well.. Yeah you’re right but you also forgot Kate’s constant obsession with her hair styles! That said, she has done pretty well for herself since Voyager in the NetFlix series Orange is the New Black.

2019-04-25T18:30:39Z

In the table below you will find the records of stratospheric balloons launched from different countries and places during 1976, which are currently available in StratoCat's database. Each row shows basic data about the launch base from which departed, date and time of the launch, and if available the duration of the mission and the site of termination or landing place of the payload. Palestine (TX) 10/21 F 3 h 60 CM INFRARED TELESCOPE Payload destroyed in free fall due to parachute malfunction.

2019-04-24T22:53:07Z

You are visiting the placeholder page for Robert Davidson. This page is here because someone used our placeholder utility to look for Robert Davidson. We created this page automatically in hopes Robert Davidson would find it. If you are not Robert Davidson, but are an alumni of John Jay High School Hopewell Junction, NY, register on this site for free now.

2019-04-18T22:20:34Z

Synopsis: Takeo Watta inherits a company upon his father's death. The company focuses on space travel, and the transformable robot Trider-G7 is their greatest creation. When an evil space organization lead by Lord Zakuron starts attacking Earth, Watta has to use Trider in a more combat-oriented way.

2019-04-23T11:58:22Z

i go every month to support amanda and “eat mor chikin”. usually i’ll find a group to sit with and i’ll be there the whole night. this time i had a mission. several months ago i was moved to the “creative” team at sandals. it has been a great change, but a challenging one. the multi-media team consists of justin, larissa and me. its been exciting, fun, trying and exhuasting at times. at sandals we rely on the media team for everything. and this trio can’t do it alone anymore. so my mission and the mission of sandals is to find those who would be willing to volunteer their time during the week to build this team. we need people who can sew, build sets, create for web and print media, film and edit for sunday announcements and more.

2019-04-19T18:20:42Z

22/02/2013 · Kid tries to show his new chinese neighbor how to eat oreos.... Use this persuasive paragraph planning template when studying persuasive writing with your students. Encourage students to use the planning template to help organise their ideas before writing. I don't have a favorite way, I don't like Oreo cookies. You probably come from a rich family, and like to wear nice things, and go to up-scale restaurants. You are particular and fussy about the things you buy, own, and wear. Things have to be just right. You like to be pampered. You are a prim.

2019-04-24T07:51:25Z

Why do we run? Because kids are made to move! And, a kid in motion stays in motion for life - and that's a good thing. Since 1995, we've helped kids unlock their potential and adults discover their inner Coach by joining, starting, or supporting a Marathon Kids running club in their home, school, out-of-school time organization, or camp. Marathon Kids works for any kid, at any fitness level. Kids set their goals and track their progress on a journey to complete four marathons, or 104.8 miles, over the course of the running club season. They run, or walk, a lap at a time, at a day at a time, and before they know it they’ve gone farther than they ever dreamed. (414-534-7425) to request adding your event.

2019-04-22T06:17:59Z

These lamps will give a special and warm atmosphere to your interior ! Soufiane Aissouni is a young interior designer and scenographer. Graduated from Lasalle College in Marrakech, he began his career in one of the largest event agencies in the ocher city, where he realized the ephemeral decoration of private events and weddings. With this experience, he then joined an interior design company and participated in the creation of private villas and apartments. He continues his activity today, while creating his own furniture and home accessories. Through his collection of lamps, he wants to develop Moroccan crafts by collaborating only with local artisans to preserve this heritage. Lamba is the name of his first collection. It is the meeting between a local knowledge and a minimalist design, simple and refined forms. Lamba presents a series of street lamps and bedside lamps. Made of metal and raffia, these lamps will give a special and warm atmosphere to your interior.

2019-04-20T19:01:42Z

Thank you! Someone from the Candelaria team will contact you shortly. Candelaria Design's mission is to Inspire Living and one of the ways we do that is through our Candelaria Design Tours. Over the course of the last 18 years we have been orchestrating tours of Italy and Spain personally guided by Principal and founder, Mark Candelaria. Our tours feature the architecture, food, wine but more importantly the lifestyle of the countries and places we tour. Group Photo from our 2016 Tour in Assisi. Welcome to our Candelaria Design Tour Italy! We have just completed our 2016 Tours which were our 13th & 14th Tours with our first being in 2000. Every year we take a select group of travelers who are interested in a very personal and unique adventure in Italy. Anyone and everyone is welcome and we have had travelers join us as far away as Australia. You can relive and experience our 2016 tour on our Lifestyle Blog right here on our website and on our Candelaria Design Tour Italy Facebook Page. Our 2018 Tour is SOLD OUT and has us departing on September 12th and we will end in picturesque Venice, Italy, returning to the US on September 25th!!! Some of us will be continuing on for a three day extension at the Villa d'Este at Lake Como where Isabel and I will celebrate our 5th wedding anniversary that took place right there on the shoreline of Lake Como. We will be departing on Wednesday, September 12th and will arrive in Florence where we will enjoy two days and two nights. From there we will move to our farmhouse compound in Umbria where we will explore Umbria and Tuscany off the beaten path. After a week in the country we will drive to Venice, Italy for three days and three nights featuring a day trip to Murano and a tour of a a glass factory. Every minute and every dollar is maxed out for an experience that will make you want to join us on new adventures. Always having good times - here on the streets of San Gimignano. Our 2018 Tour Italy will begin in Florence Italy where we will spend two nights and three days at a spectacular hotel and will explore this beautiful city of the Renaissance. From dining at the foot of the Duomo on one evening to dining in the hills above Florence at a 5 star venue we will experience the full gamut of Italian cuisine. I personally take you on a beautiful morning walking tour of the city and we climb the Duomo campanile for a little work out. Special tours can be set up of the Uffizzi Gallery, Accademia, Bobili Gardens, etc. From Florence you are provided your own private rental car and the group convoys to the Italian countryside of Umbria and Tuscany where we spend a week in an authentic farmhouse compound in the hills of Umbria. We are welcomed by a home cooked meal and a swim in the pool. The next morning we have brunch at the Villa Piazzano in Tuscany and then we explore the picturesque hill town of Cortona featured in the Frances Mayes book and then movie, Under the Tuscan Sun. We enjoy the sunset and then dine in Cortona. The rest of the week features a day in Assisi, a full day wine tour with our own wine guide, Pino Teresi, featuring the hill towns of Montalcino, Pienza, and Montepulciano. We then explore San Gimignano and Siena. A couple days are mixed in to relax and enjoy the countryside and include a 4 hour cooking class in the Farmhouse. Our pool at the Umbria Farmhouse Compound. We finish each trip in a different venue. In 2016 we took the convoy to Lake Como in June and Positano and enjoyed the Amalfi Coast in September. In 2018, we will conclude the trip at the Hotel Danielle in Venice Italy. Our Candelaria Design Tour Italy runs 14 days and we take no more than 20 travelers each tour. We have many repeat travelers so new spots are hard to come by. Our tour run approximately $8500 per person or $16,000 per couple and includes round trip coach air fare which can be upgraded, hotels, farmhouse, rental car, several dinners, wine tour, cooking class, pre-trip post trip dinners in Scottsdale. Enjoy this video from our 2013 Candelaria Design Tour Italy along with clips from prior trips! Don't miss this opportunity to see and experience Italy in a unique way. Call us at 480-874-7104 or email us at info@candelariadesign for details. Our Candelaria Design Tour for 2019 will feature an extravagant finish in Treviso & Venice Italy and will feature the villas of Palladio of northern Italy along with tours of a prosecco winery. Go to our Contact Us page and email us your inquiry to hold your spot for this once-in-a-lifetime journey.

2019-04-22T13:12:17Z

This water-resistant windbreaker from Season 5 showcases perfectly Mr. West’s brand talent to combine function and fashion for everyday use. This season, Yeezy presents its own interpretation of the windbreaker. A cool take on this iconic winter piece, crafted from high-quality materials and elegantly detailed with a half zip fastening, a drawstring waist, long sleeves with elasticated cuffs and Calabasas crest at the chest.

2019-04-20T20:10:23Z

Intuit Inc. (Nasdaq: INTU) today announced it has entered into a definitive agreement to purchase Check, a Palo Alto, Calif.-based leader in mobile bill pay that serves 10 million registered users. The acquisition will help accelerate Intuit's ability to offer bill pay across small business and personal finance products and create opportunities to retain, attract and serve additional customers. Check's highly-rated mobile app automates and consolidates the bill pay process all in one place, reducing the complexity for consumers. Check customers can monitor bills and accounts, receive alerts when bills are due or funds are low, and pay bills automatically. Intuit's personal finance solutions, Quicken and Mint, have historically provided customers a look back at their transactions to help them plan for the future. Consumers increasingly want mobile apps that allow them to take action with their money and help them accomplish every day financial tasks, such as bill pay and household budgeting. U.S. consumers were expected to pay more than 14.7 billion bills in 2013, according to an Aite Group report, citing the most recently available data. Online and mobile payments were expected to account for nearly half of all bills paid that year. "Intuit started when founder Scott Cook wanted a better way to balance the family checkbook," said Barry Saik, senior vice president and general manager of Intuit's Consumer Ecosystem Group. "Our commitment to solving important personal finance problems is steadfast. By joining with Check, we continue to address consumer needs and are taking the next step in the evolution of personal finance capabilities." Through the acquisition, Intuit gains a critical consumer payments capability that will allow the company to streamline interactions between consumer and small business customers, consistent with Intuit's vision of enabling products to work together as an ecosystem. Once the transaction closes, Check will join Intuit's Consumer Ecosystem Group. The Israel site will become an Intuit location, adding to the company's growing global portfolio. Guy Goldstein, Check's co-founder and CEO, will serve as vice president and report to Saik. "Mobile is a key driver of bill pay opportunities", said Goldstein. "We look forward to merging our talent, mobile mindset and spirit of innovation with Intuit to build products that delight consumers and become a part of their everyday financial lives."

2019-04-22T00:03:53Z

"The Boudoir of Jean Bardot" This week in free things to do we have a leather and art show, a handful of V-Day pop-ups, beer parties, and it's the final weekend for the Saint Paul Winter Carnival and the Art Shanties Project. Photo exhibit focusing on the fetish world. Opening reception 7-10 p.m. Fri., Feb. 9, with informal fetish fashion show at 8:30 p.m. Free. Rogue Buddha Art Gallery, 357 13th Ave. NE, Minneapolis; 612-331-3889. Come celebrate the loss of this 47 year old landmark. Bring a cangle; there might be free Arby's from the corporation as well. 8-10 p.m. 1116 W. Lake St., Minneapolis. With Flowerstalks and Maejoy. 10 p.m. Feb. 9; Free. 331 Club, 331 13th Ave. NE, Minneapolis; 612-331-1746. With Novacron, Motari Jaguar, and VVolf Mask. 9 p.m. Feb. 9; Free. Hexagon Bar, 2600 27th Ave. S., Minneapolis; 612-722-3454. This your last weekend to check things out. In Rice Park you’ll find ice sculptures, the ice castle, and free art exhibits nearby. Over at the Minnesota State Fairgrounds there’s snow sculptures and a giant slide. For the complete schedule, see the official website, www.wintercarnival.com, or call the main hotline at 651-223-7400 for details. Rice Park, 109 W. 4th St., St. Paul. Friday through Saturday. Hockey- or figure-skate rentals are $4, or free with a Wells Fargo credit or debit card. Rice Park, 109 W. 4th St., St. Paul; 651-632-5111. 10 p.m. Every Fri.; Free. The Corner Bar, 1501 Washington Ave. S., Minneapolis; 612-339-4333. Watercolor monoprints. Opening reception 6:30-9 p.m. Fri., Feb. 9. Free. Highpoint Center for Printmaking, 912 W. Lake St., Minneapolis; 612-871-1326. Outdoor winter celebration featuring ice skating, snowkiting, ice bar, snowga, golf tournament, brunch buffet, and live music from Viva Knievel. Visit wayzatachillyopen.com for full lineup and additional info. 3-9 p.m. Feb. 9; 9 a.m.-10 p.m. Feb. 10; Most events are free. Lake Minnetonka Wayzata Bay, 402 E. Lake St., Wayzata. Group show. 5-7 p.m. Altered Esthetics at the Southern Theater, 1420 S. Washington Ave., Minneapolis; 612-378-8888. All vinyl nights with variety of DJs. 10:30 p.m. Every Fri. and Sat. from March 9; Free. The Lexington, 1096 Grand Ave., St. Paul; 651-222-5878. Author presents her new book, 'Automating Inequality: How High-Tech Tools Profile, Police, and Punish the Poor,' in conversation with professor Joe Soss. 7 p.m. Feb. 9; Free. Magers & Quinn Booksellers, 3038 Hennepin Ave. S., Minneapolis; 612-822-4611. Free public skating rink with a warming house and complimentary skate rental. Daily from Nov. 15-March 10; Free. Loring Park, 1382 Willow St., Minneapolis. Group show featuring responses to Sohab Sepehri's poem "Water's Footsteps." Opening reception with artists 7-10 p.m. Fri., Feb. 9. Free. Pirsig Projects, 734 E. Lake St., Minneapolis. Hosted by Silly Miss Tilly. All ages. 5:30 p.m.-8:30 a.m. Every Fri.; Free. Can Can Wonderland, 755 Prior Ave. N., Ste. 4, St. Paul; 651-925-2261. Group tap dance lessons. 4-6 p.m. Every Fri. from Aug. 4; Free. Can Can Wonderland, 755 Prior Ave. N., Ste. 4, St. Paul; 651-925-2261. The activist poet presents pieces of spoken word from her new collection, 'Paradigm Lost,' with projected visuals. 7 p.m. Feb. 9; Free. Boneshaker Books, 2002 23rd Ave. S., Minneapolis; 612-871-7110. 8 p.m.; Free. Black Dog Cafe, 308 Prince St., St. Paul; 651-228-9274. With drinks and appetizers, meet and greet with the artist, and door prizes. 12 p.m. Feb. 9; Free. Coffman Memorial Union, 300 Washington Ave. SE, Minneapolis; 612-624-4696. 7:30 p.m. Feb. 9; Free. Ted Mann Concert Hall, 2128 4th St. S., Minneapolis; 612-624-2345. Featuring snowshoe tours of the Minneapolis Sculpture Garden, cold-weather fashion photo shoots, acting workshop, and Little Box Sauna warm ups, with free gallery admission all day. 10 a.m.-3 p.m. Feb. 10; Free. Walker Art Center, 725 Vineland Place, Minneapolis; 612-375-7600. Pop up features handcrafted leatherwork and lingerie, specialty preserves, and more. A portion of sales will be donated to the Sexual Violence Center. Saturday, 3-7 p.m. Seen the Future, 2223 E. 35th St., Minneapolis. With Wetter and Cave Light. 10 p.m. Feb. 10; Free. 331 Club, 331 13th Ave. NE, Minneapolis; 612-331-1746. Featuring student artwork at Workhorse Coffee Bar. Saturday, noon to 2 p.m. Mid-Continent Oceanographic Institute, 2388 University Ave. W., St. Paul; 612-367-7827. Featuring a George Jones Tribute with Fletcher Magellan, Rafters, and Beneath the Crow. 9 p.m. Feb. 10; Free. Hexagon Bar, 2600 27th Ave. S., Minneapolis; 612-722-3454. Film screening, with giveaways and prizes. 2 p.m. Feb. 10; Free. F.K. Weyerhaeuser Auditorium, 75 W. 5th St., St. Paul; 651-292-3225. This is your last chance to visit the Art Shanties this year. The final weekend features musical performances, art activities, projects, and hands-on fun. For more info, visit www.artshantyprojects.org. 10 a.m.-4 p.m. Every Sat. and Sun. Free. Lake Harriet, 43rd St. W. and E. Lake Harriet Parkway, Minneapolis. Screenings of films from Minnesota and across the country, hosted by authors James Kennedy and Pete Hautman. RSVP and more info here. 3 p.m. Feb. 10; Free. Minneapolis Central Library, 300 Nicollet Mall, Minneapolis; 952-847-8107. Featuring spicy foods from local artisans and cocktails made with house-made spirits. 2-7 p.m. Feb. 10; Free. Bent Brewstillery, 1744 Terrace Drive, Roseville; 844-879-2368. A photographic series by Alex Butterfield and designer Samantha Rei. Opening reception 5-8 p.m. Sat., Feb. 10. Free. Showroom, 612 W. Lake St., Minneapolis; 612-345-7391. 8 p.m. Feb. 10; Free. Macalester College Janet Wallace Fine Arts Center, 1600 Grand Ave., St. Paul; 651-696-6000. Featuring eight vegan-friendly local vendors selling their wares. 12-3 p.m. Feb. 10; Free. Sociable Cider Werks, 1500 Fillmore St. NE, Minneapolis; 612-758-0105. There will be an opening reception from 6 to 8 p.m. Saturday, February 10. Free. Midway Contemporary Art, 527 2nd Ave. SE, Minneapolis; 612-605-4504. Kenwood Symphony and Two Rivers Chorale Presents: Viva Verdi! 4 p.m. Feb. 10; Free; donations accepted. Minnesota Masonic Heritage Center, 11411 Masonic Home Dr., Bloomington; 952-948-6500. All-ages open house featuring hands-on Valentines-themed activities, art sale, and sweet refreshments. More info at www.mnbookarts.org. 10 a.m.-2 p.m. Feb. 10; Free. Minnesota Center for Book Arts, 1011 Washington Ave. S., Minneapolis; 612-215-2520. Portraits of LGBTQ players from the Twin Cities Goodtime Softball League. There will be an opening reception from 6 to 9 p.m. Saturday, February 10. Free. Soo Visual Arts Center, 2909 Bryant Ave. S., Minneapolis; 612-871-2263. Group art show. Opening reception 6-9 p.m. Sat., Feb. 10. Free. Soo Visual Arts Center, 2909 Bryant Ave. S., Minneapolis; 612-871-2263. 7:30 a.m. Feb. 10; Free. Temple of Aaron Synagogue, 616 S. Mississippi River Blvd., St. Paul; 651-698-8874. Indoor marketplace featuring local food, ceramics, jewelry, art, music, and home products. More info at millcityfarmersmarket.org. 10 a.m.-1 p.m. Feb. 10. Free. Mill City Museum, 704 S. 2nd St., Minneapolis; 612-341-7555. 11 a.m.-4 p.m. Feb. 10; Free. California Building, 2205 California St. NE, Minneapolis; 612-788-5551. Photographs by Tia-Simone Gardner. Opening reception and artist talk 5:30-7:30 p.m. Sat., Feb. 10. Free. FilmNorth, 550 Vandalia St., Ste. 120, St. Paul; 651-644-1912. Works by Amy Tillotson and Greg DeGrace. Opening reception 4-7 p.m. Sat., Feb. 10. Free. Banfill-Locke Center for the Arts, 6666 E. River Rd., Fridley; 763-574-1850. Dog owner meet up with merch for sale, treats for the pups, photos, food, and drinks. 12-5 p.m. Feb. 11; Free. Modist Brewing Co., 505 N. 3rd St., Minneapolis; 612-454-0258. Featuring a beer tent, live music, door prizes, group bike rides, food trucks, and silent auction. 12-4 p.m. Feb. 11; Free. Surly Brewing Company, 520 Malcolm Ave. SE, Minneapolis; 763-999-4040. Featuring a variety of flavors to sample with pint purchases available. This month's special flavors: Blood Orange Cream and Blackberry Sorbet. 3-6 p.m. Feb. 11; Free. Indeed Brewing Company, 711 15th Ave. NE, Minneapolis; 612-843-5090. Outdoor yoga session near the art shanties on Lake Harriett, hosted by Yess Yoga. 2 p.m. Feb. 11; Free. Lake Harriet, 43rd St. W. and E. Lake Harriet Parkway, Minneapolis; 612-230-6475. Featuring handmade/hand-dipped vegan chocolate truffles and dried flora and one wall hangings. Sunday, noon to 4 p.m. Seen the Future, 2223 E. 35th St., Minneapolis. Valentine's meet up for vegetarian singles. More info here findveglove.com/event/165210. 3-5 p.m. Feb. 11; Free. Republic at Seven Corners, 221 Cedar Ave. S., Minneapolis; 612-338-6146. 4:30-6:30 p.m. Feb. 11; Free. Marjorie McNeely Conservatory at Como Park, 1225 Estabrook Drive, St. Paul; 651-487-8200. Screening of the biggest DJ competition in the world, with giveaways and vinyl sale 11 a.m.-4 p.m. Feb. 11; Free. Fifth Element, 2411 Hennepin Ave. S., Minneapolis; 612-377-0044. There’s something special about homemade gifts, but not everyone is crafty. So consider going for the next best thing: handmade gifts. With Valentine’s Day right around the corner, Minneapolis Craft Market is heading to Modist for a day of romance, beer, and slow jams. Whether you’re shopping for your sweetheart, looking for a gift for your BFF, or just want an excuse to day drink and shop, you can do that here. There will be a variety of makers sharing their wares; check out stationery, gorgeous gemstone jewelry, items for dogs, and classic V-Day gifts like chocolate, rings, and flowers. 12-5 p.m. Feb. 11; Free. Modist Brewing Co., 505 N. 3rd St., Minneapolis; 612-454-0258. Featuring folk songs, dancing, hands-on custom experiences, traditional foods and snacks, and carnival games. 12-4:30 p.m. Feb. 11; Free. Valley View Middle School, 8900 Portland Ave. S., Bloomington; 952-848-3500. 7-11 p.m. Every Sun.; Free. Schooner Tavern, 2901 27th Ave. S., Minneapolis; 612-729-4365. 3 p.m. Feb. 11; Free. Temple Israel, 2324 Emerson Ave. S., Minneapolis; 612-377-8680. Featuring kids' disco, story time with the Current hosts, a reading by author Nacy Carlson, children's art activities, pop up classical performance by Chione, and live music from Bato Bato, Brian Just, DJ Keezy, and Andy Cook. 10:30 a.m.-5 p.m. Feb. 11; Free. Minneapolis Institute of Art, 2400 Third Ave. S., Minneapolis; 612-870-3131. Author/poet presents her new collection, 'Holy Trinity: Maiden, Mother, Crone.' 4 p.m. Feb. 11; Free. Common Good Books, 38 S. Snelling Ave., St. Paul; 651-225-8989. Featuring exhibitors, experts, and designers, with free seminars, and kid's activity center. More info at www.homeremodelingfair.com. 10:30 a.m.-3 p.m. Feb. 11; Free. Hopkins Eisenhower Community Center, 1001 Highway 7, Hopkins; 952-988-4066. 7-9 p.m. Every Sun. from Sept. 24-Dec. 30; Free. Riverview Cafe & Wine Bar, 3745 42nd Ave. S., Minneapolis; 612-729-4200.

2019-04-26T14:42:50Z

Your Brain on Good Communication : Why Stories "Stick" What makes a message easy to understand? What makes a message memorable? What makes a message effective at helping you achieve your objectives? Unless you’re cutting ties with an individual, your goal in giving feedback should be to motivate the person to improve. So, how can you soften the blow without beating around the bush? What's Your Strategy for Connecting with Customers? Learn more about this exciting partnership from the "Practice Your Pitch" organizer herself, 3C's own Christina Brennan! Stories can be entertaining and keep your audience engaged. They also help people retain information.

2019-04-23T17:57:36Z

Commissioned by the Gemeente Amsterdam we organised a gathering of 50 advertising professionals, out-of-the-box thinkers, scientists, students, artists and engaged citizens to found common ground on how to let society benefit from billboards (instead of commercial companies). Formulating goals is one thing – achieving them is what it is all about. We think that Pop-Up Companies are the way to do it. Therefore 10 teams on 10 different locations around the world will work together at a festival in November to start PUCs that contribute to the SDGs the UN defined for 2030.

2019-04-20T02:43:52Z

Since your pipes are more than likely hidden behind cupboard doors and out of sight, you may not give them a second thought. However, you can have a lot of cold air pooling in from large gaps around the pipes. Open the doors, move any items blocking your view of the pipes, and look for open gaps where air can come right in. Clean off the area and use expanding foam to seal up those gaps. Not only will this help prevent the loss of heat, but it can also help you to keep pests from easily entering into your home and causing a possible infestation. One of the sneaky areas where you can have bursts of cool air entering the house is your electrical outlets. Check for possible leakage by holding a candle near one, or even use a lighter. If the flame dances a lot when it gets near the outlet, this is a sign that cool air is coming right into the house. You can use a Philips screwdriver to quickly remove the plate and use some caulking to seal the area and prevent further instances of air coming inside. Be sure to run the same check on each outlet throughout the house. There's a good chance your attic is already insulated, but many people don't think of insulating the attic access door. Since air travels upward, the warm air that you are generating in the house can go right up into the attic, leaving the cooler air in the living area of the home. You can purchase some insulation and install it directly on the attic side of the attic access door. Along with doing this, you also want to make sure that the door fits snugly so you won't be losing air through the cracks as well. The basement will more than likely be one of the coldest areas in your entire house. This is due to the fact that it is the lowest area in the house, and basements are generally constructed of materials that also hold in the cold, such as concrete. You'll want to get insulation and install it on the inside of the door that leads into the basement. If you use a regular door, then you'll want to make sure it is a well-insulated one. If it isn't then it's time for you to have it replaced with one that will help provide better insulation.

2019-04-22T00:17:43Z

Weight bearing 2 Step Platform is designed to accommodate digital DR Panels, CR Cassettes and Analog. This product is designed for easy mobility plus stability while allowing for easy weight bearing imaging on the foot, ankle and knee. RC Imaging’s 2 Step Platform is constructed of high density ABS plastic and stainless steel.

2019-04-20T10:16:07Z

The 6th Element vaporizer has 2 fans in the back that blow warm air through your herb, pushing an awesome hit of vapor through your vapor whip and into your lungs. Comes with everything you need plus a remote control for maximum comfort. Click the button below to add the The 6th Element Vaporizer with Remote Control to your wish list.

2019-04-20T05:16:27Z

In this module you will explore core concepts, theories, and models in terms of the psychosocial aspects of health and illness. We will look at biological systems of the body and their relationship to illness, as well as issues involved in measurement and investigation of psychosocial aspects of health and illness. An important focus will be ways in which psychology can be applied to preventing or reducing the health impact of stress. Module disclaimer: We regularly review our course content, to make it relevant and current for the benefit of our students. For these reasons, course modules may be updated. This is an unofficial blog authored by Carol Percy (a member of the course team). If you'd like to contact us, please use one of the contact forms throughout the site, Alternatively, you may like to contact us via the university's official website.

2019-04-22T14:49:37Z

We’re advancing fire safety & security levels up a notch with products from the world’s biggest names in asset protection. Honeywell’s INTEVIO Public Address and Voice Alarm system is the ideal solution for single buildings. It is an integrated solution that can provide better stability, cost-savings, higher user experience and performance. The HEL2R1 CCTV cameras are cost effective surveillance solutions suitable for various applications, including schools, hospitals, commercial sites, retail stores, warehouses, banks among others. It is very ideal for cost-effective upgrade to high definition surveillance. The HBL2R1 CCTV camera is cost effective surveillance solutions suitable for various applications, including schools, hospitals, commercial sites, retail stores, warehouses, banks among others. It features 3.6mm built-in lens, 1080P resolution, & IR night vision.

2019-04-19T16:20:17Z

This entry was posted in Mental Health on October 26, 2015 by Platinum. For countless individuals that struggle with dementia, completing even the most basic tasks on a daily basis can be a challenge. Various things, including stroke, can cause dementia, brain trauma, Parkinson’s disease, Alzheimer’s Disease, Huntington’s Disease, or other genetic defects that can influence the structure and function of the brain. Symptoms of dementia can vary on a individual basis and on degree of severity, with some people experiencing more mild symptoms and others experience worsening symptoms over time. While there are no current cures for dementia, there are several steps that can be taken to help improve quality of life for the person who might be suffering. Prescription medications may be useful for helping an individual improve mood, behavior, or general mental functions. Any prescription medications should be thoroughly discussed with a physician. If other prescription medications are also being taken to treat co-occurring conditions, it is important to review possible drug interactions. Individuals with dementia may have difficulty adhering to a consistent medication schedule. Other common difficulties involving prescription medications include forgetfulness of when a drug was taken. Because of the symptoms associated with dementia, an individual with this condition may struggle with following a prescription drug regime. This can lead to prescription drug misuse, which can result in a host of other complications, and ultimately, mismanagement or worsening of dementia. If you or someone you care for is dealing with dementia and taking prescription medication, be sure to have an efficient system for regularly consuming medication. This might including having someone come over to help administer the correct medications, including a trust friend, family member, or nurse, or pre-sorting daily medications into a pill box that makes it easier for the user to take. If you are struggling with taking your medication consistently because of symptoms of dementia, be sure to talk with your doctor and reach out for the appropriate help you need. Have you cared for an individual who takes multiple medications? What are ways that you have helped ensure that medications are taken correctly? What might be some tips or suggestions that you would share with individuals who take multiple prescription medications?

2019-04-19T08:44:55Z

I have been very impressed with Diane Mitsch Bush, particularly with her knowledge of complex issues and her willingness to work with all stakeholders to find solutions. One of the issues I find most concerning is climate change. We have seen the effects locally with the 416 Fire. Our warming temperatures and drought contributed to the 416 Fire’s severity. Climate change will also cause a reduced snowpack and a much faster snowmelt. This will result in less water during the summer for agricultural and recreational uses. Diane Mitsch Bush understands the importance of water to the agricultural and recreational communities. She has proven experience developing Colorado’s Water Plan. She has worked hard to protect water resources for our state. She understands how carbon emissions significantly contribute to climate change and that placing a fee on carbon, with payment of a dividend to all households, will significantly reduce carbon emissions. She has pledged to join the Climate Solutions Caucus when elected to the House of Representatives. Scott Tipton has done nothing to address climate change and does not seem to understand how climate change will adversely affect our water and agricultural and recreational communities due to the reduced snowpack and rapid snowmelt. Please join me in voting for Diane Mitsch Bush for U.S. House of Representatives. She will listen to us, her constituents, and she is committed to working across the aisle to find solutions to these concerning issues.

2019-04-24T10:21:28Z

The Maxicosi-outlet.co.uk affiliate program grants your patrons access to one of the global industry leaders in products for growing children. The company strives to supply parents with the most advanced products and services to make parenting a bit more easy and way more fun. Their strong brands include Maxi-Cosi, Bébé Confort, Quinny, Safety 1st, Baby Art, and Tiny Love. This program offers a 30-day cookie duration. Sign up with FlexOffers.com to learn more about the Maxicosi-outlet.co.uk affiliate program today!

2019-04-23T01:53:52Z

The Pneumatic Fa bric Stiffness Tester ASTM provides the fabric and apparel industries with a consistent fast, and accurate method of determining fabric stiffness in compliance with ASTM Spec. D4032, Circular Bend Test Method. a simple to use, rugged instrument based on a design described in internationally recognized test standards such as ASTM D1388. Employing the principle of cantilever bending, a rectangular specimen is supported on a smooth low-fiction horizontal platform with a 41.5” (0.724 rad) or 45” (0.785 rad) adjustable bend angle indicator below the plane of the platform surface. While using this Fabric Stiffness Tester, a weighted slide is placed over the specimen and is advanced at a constant rate. Using Taber’s Fabric Stiffness Tester- as the leading edge of the specimen projects from the platform, it bends under its own mass. Once the material flexes enough to touch the bend angle indicator, the test is stopped. The length of the overhang is then measured and flexural rigidity and bending modulus can be calculated. Ideal for testing most textile fabrics (e.g. woven; layered; pile; knitted; napped), Taber’s Fabric Stiffness Tester has been utilized to evaluate the stiffness properties of blankets, airbag fabrics, protective clothing, geotextiles, etc. Fabrics may be untreated or treated. Taber’s Fabric Stiffness Tester can be used (via the Taber Test) to evaluate leather, paper, plastic films, and other flexible sheet materials.

2019-04-21T08:53:44Z

Whether you’re a seasoned DIY pro or just want to spice up your wardrobe on the cheap, our new column DIY Chic is here to show you how to stay stylish on a college budget. If you are looking for more DIY inspiration, check out our past tutorials on creating your own button earrings or customizing your favorite class organizer. This week, I am sharing an easy sewing trick to transform your old straight-leg, wide leg, bootcut or flared jeans into skinnies. This is also a simple way to tailor your pants if they no longer fit. Skinny jeans have been in style for some time now and it doesn’t look like the sleek silhouette is going anywhere soon! This project does require a sewing machine and basic sewing knowledge, but is a great place to start if you have been wanting to hone your sewing skills. If you don’t have a sewing machine, check to see if a friend or family member has access to one. Also, some campuses also have a student art or craft center for student use, so we recommend looking into that as well! 1. Put your old pair of jeans on inside-out. Yes, it will look and feel a little weird. But since you will be working with the inside seams, this is the easiest way to measure out the new fit. 2. Starting at the inside crotch of the pant, pinch and pull the fabric to your desired fit. Take a look at the photo below to get a better idea of the process. Try to estimate how many inches of fabric you’ll want to take in. 3. Using your fabric marker or chalk, mark the fabric where you pinched. This will be where you will sew the new seam. Continuing this process, work your way down the inside leg of your jeans.Repeat on the inside of the opposite leg. Be careful to allow a little extra room in the knees and calves of the jeans – too tight, and you won’t be able to get them on and off. 4. If you want to get fancy, you can repeat these steps on the outside seams as well – this will make for more work, but can also create a more finished, uniform appearance. If you do decide to start pinching the outside seams too, make sure to take the lines you’ve already made into account so your jeans won’t be too tight. Also, if you do the outside seams, it might be necessary to taper the seam slightly at the pocket to avoid an awkward bump. See photo 4 below for a better idea of this step. 5. Before you start sewing, you might want to pin the layers of fabric together for better control. 6. Starting with the insides of the legs, use your machine to carefully sew down the lines/marks you made on the inside of your jeans. (If you’re doing the outside seams too, continue along the outside of the legs as well.) When you’re finished, try on your jeans to make sure the fit is right. You might need to rip out the seams you’ve sewn – don’t be afraid to try again! 7. When you are satisfied with the fit, trim the excess fabric and old seams away – leave about 1/4 to 1/2 inch of extra fabric. Zig-zag stitch the unfinished seams for a polished finish and to help prevent fraying. And there you have it! A simple and relatively easy technique for transforming an older pair of jeans into something fresh. It’s a great way to recycle an older pair of pants that you don’t wear much anymore. What do you think of this sewing trick? Do you have a favorite way to recycle or update old pieces of clothing you no longer wear? What other types of DIYs would you like to see next? Let us know in a comment!

2019-04-26T14:10:29Z

Dominic Paquet Tickets: All 2018-2019 Events! QueenBeeTickets.com is a family-owned and operated ticket exchange offering authentic tickets and legitimate savings on today's most popular events. Dominic Paquet ticket prices are constantly being monitored and adjusted in order to compete for your business. For a limited time, customers can save on already discounted Dominic Paquet tickets by taking advantage of our valuable and exclusive promo code. Online shoppers are invited to compare our bottom line prices against other ticket providers offering similar seats. Discount Dominic Paquet Tickets for Sale at QueenBeeTickets.com! If you're looking for a safe and reliable online destination to buy discount Dominic Paquet tickets, you're definitely in the right place! The exchange at QueenBeeTickets.com offers an extensive selection of Dominic Paquet tickets for sale in all price ranges. Whether you are looking for discount Dominic Paquet tickets or front row seats, we've got it covered. In many cases, we're able to offer these popular seats even after the primary market has sold out! When fans are searching for cheap Dominic Paquet tickets for sale, QueenBeeTickets.com has that covered, too. We compare our own ticket prices to our direct competitors every day. This is done to ensure that our ticket prices remain among the cheapest in the industry. We offer lower prices than most online ticket establishments on the web. The profits that we DO NOT make by overpricing, we hope to make up for in sales volume. Only ticket companies with substantial inventories are able to offer these popular tickets for less. We offer discount Dominic Paquet tickets by keeping our service fee lower and by offering a generous promo code.

2019-04-24T07:51:35Z

The captivating image below, is segment of 2019 Vuhl 05 document which is categorised within Pictures, 2019 Vuhl 05, and posted at December 1st, 2018 07:12:30 AM by Bismillah. Here is wanted notification on 2019 Vuhl 05. We have the finest sources for 2019 Vuhl 05. Check it out for yourself! You can find New 2019 Vuhl 05 Research New guide and view the latest 2019 Vuhl 05 in here.

2019-04-22T16:06:38Z

This organic style wooden frame is 15" inches high by 15" inches wide. The inner frame is composed of wood composite and a beautiful Paulownia wood. The wood is wisely decorated in white print with ornate flowers, and patterns, as well as emotion inspiring words to frame an important memory. DEMDACO Treasure Memories Frame Wall Art by The Kelly Rae Roberts Collection is a picture frame to display milestones, life events, and memories one wants to hold onto for years to come. The design of this frame is suitable for any home décor or style to add warmth and elegance while appealing to our natural side with a gentle wood finish. This organic style wooden frame is 15" inches high by 15" inches wide. The inner frame is composed of wood composite and a beautiful Paulownia wood cut from a tree known for its deep roots, strength, and reliability much like that of loved ones and friends. This frame does not end there -- the wood is wisely decorated in white print with ornate flowers, and patterns, as well as emotionally inspiring words to frame an important memory. The sentiment on this treasure memories frame is one that depicts the significance of love, memories, and time spent together. "May we always treasure the smallest moments for they create sacred memories of connection, togetherness, and love. The design of this frame is suitable to apply to any home décor or style to add warmth and elegance while appealing to our natural side with a gentle wood finish. This Treasure Memories Frame is the perfect gift for an expectant mother, your own parents or grandparents, or for a loved one in your home. This frame can also be given as an excellent addition to any home at a housewarming party, or to add an emotional touch to any wall. Complete your home or the home of someone you love with a piece that fully encapsulates the joy of life. Sentiment on Frame: May we always treasure the smallest moments for they create sacred memories of connection, togetherness, and love. DEMDACO Treasure Memories Frame Wall Art by The Kelly Rae Roberts Collection.

2019-04-22T16:38:23Z

Lacy, K. & Huffman, W.E. (2016). Consumer Demand for Potato Products and Willingness-to-Pay for Low-Acrylamide, Sulfite-Free Fresh Potatoes and Dices: Evidence from Lab Auctions. Journal of Agricultural and Resource Economics, 41(1), 116-137.

2019-04-21T00:26:40Z

working at home today 🙂 And while my PC generates several hundred isotropic random phase fractal textures I thought I’d drop a link to the new song by Bard Edlund, Two Can Go Low (I recorded the bass for him). He’s got a couple more new songs too, all available at his Edlundart page. This entry was posted on Tuesday, May 1st, 2007 at 10:01 am and is filed under Music, why not have a listen?. You can follow any responses to this entry through the RSS 2.0 feed. You can leave a response, or trackback from your own site.

2019-04-26T06:53:05Z

I recently read Francis Plug: How To Be A Public Author and I have to say I loved everything about this book. It is a work of a genius. So incredibly funny. Well he is back. Francis Plug: Writer In Residence by Paul Ewen (Galley Beggar Press) is released on 4th October and I can promise you, if you loved the first instalment you are going to really enjoy this. Well he has only gone and done it! Francis Plug is now an author, he has unleashed his book out into the world, but is the world ready for the now published author. As you may recall if you have read the first book, our lovable character is pretty much penniless and lives in a garage which is no more than a box. So now Francis Plug has his book out there he needs to earn some money, so incredible he is offered the role of ‘Writer-in-Residence’ at Greenwich University. Now prepare for a barrel of laughs. Francis now realises that there are so many empty offices within the University and decides that one of them will fit the job as his home. There are one or two drawbacks, there is no bathroom for one and then what if someone discovers he has literally moved in? Thanks to his boss in the Creative Writing Department is Dr Alex Pheby and he is arranging The Greenwich Book Festival and of course Francis jumps at the chance of helping, by trying to persuade his fellow famous writers to appear at the festival. Francis loves to attend author events, or is it just because there is free booze on offer. He tries his very best at every author event even at his own book signings were he seems to consume most if not all the alcohol on offer. Question is, do any of his famous author connection actually take up his offer. As part of Writer-in-Residence at Greenwich University, Francis Plug is expected to write a novel, and talk to students at the Creative Writing Department. This means interacting with people, something that Francis dislikes especially students and he does his best to avoid any places where there are students and this includes a lot of the pubs in the area. Drink and Francis go hand in hand, yet he is finding he is being barred from a lot of the pubs he is using for his Campus novel. By this time a lot of people connected to Greenwich University are just not sure about our boozy Francis Plug. There are many laugh out loud moments in this hilarious follow up novel. I attend lots of literary events every now and again you just get one and I have seen a few. I have to say Paul Ewen is fabulous writer and this is going to go down a storm. I loved Francis Plug: Writer In Residence. One I will happily raise a glass or three to. There is so much humour here, the humour just keeps on coming. What does become of Francis, and his home in the office at Greenwich University. Next May when I am at the book festival at Greenwich University I will be wandering the corridors of this famous establishment just chuckling to myself. HIGHLY RECOMMENDED. Thank you to Galley Beggar Press for the review copy of Francis Plug: Writer In Residence by Paul Ewen. Francis Plug: Writer In Residence by Paul Ewen will be published on 4th October 2018 by Galley Beggar Press and is available to pre-order through Waterstones, Amazon and through your local independent bookshop.

2019-04-26T15:17:00Z

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2019-04-25T21:55:46Z

home ideas today: the best mid-century modern sofa: a guidance. several options of expandable dining table that suit small dining rooms. several countertop materials (including thunder white granite). under-mount bathroom sink ideas. the best vessel sink vanity ideas. the best twin beds with storage ideas. best options of coffee table for outdoor use. several options of expandable dining table that suit small dining rooms. the best mid-century modern sofa: a guidance. several countertop materials (including thunder white granite). everything you need to know about lily ann cabinets.

2019-04-23T10:12:17Z