Datasets:

monology

/

pile-uncopyrighted

like 86

1. Field of the Invention This invention relates to an AFC circuit for an FM receiver circuit and an IC of the AFC circuit. 2. Description of the Prior Art Various FM receivers are conventionally known and used practically. An exemplary one of such conventional FM receivers is shown in FIG. 3. Referring to FIG. 3, broadcast wave signals received by an antenna 1 are supplied by way of a high frequency amplifier 2 to a tuning circuit 3, by which a broadcast wave signal of an aimed frequency is selected. The selected broadcast wave signal is supplied to a mixer circuit 4, by which it is converted by frequency conversion into an intermediate frequency signal (the intermediate frequency signal has the frequency of, for example, 10.7 MHz) using a local oscillation signal from a local oscillation circuit 5. The intermediate frequency signal is supplied from the mixer 4 by way of an intermediate frequency filter 6 constituted from, for example, a ceramic filter and an intermediate frequency amplifier 7 to an FM demodulation circuit 8, by which it is demodulated into an audio signal. The local oscillation circuit 5 includes a resonance circuit 51 which operates in an interlocking relationship with the tuning circuit 3. Further, automatic frequency control (AFC) is performed by an AFC circuit 9. In particular, a variable reactance element, i.e., a variable capacitance diode D51 in the circuit configuration shown in FIG. 3, is connected in parallel to the resonance circuit 51 by way of a pair of dc current cutting capacitors C51 and C52. The demodulation output S8 of the demodulation circuit 8 is supplied to a low-pass filter 91 which is constituted from a resistor R91 and a capacitor C91 as indicated by solid lines in FIG. 3, and a dc voltage included in the demodulation output S8 is extracted as an AFC voltage V91 from the low-pass filter 91. The AFC voltage V91 is supplied to the variable capacitance diode D51 by way of a buffer resistor R92 while a bias voltage V92 is supplied to the variable capacitance diode D51 by way of another buffer resistor R93. Accordingly, the capacitance of the variable capacitance diode D51 is varied in response to the AFC voltage V91, and the frequency of the local oscillation of the local oscillation circuit 5 is varied in response to a variation of the capacitance of the variable resistance diode D51 to effect automatic frequency control. By the way, the frequency conversion of the mixer circuit 4 is, for example, in Japan, lower heterodyne conversion wherein the local oscillation frequency is lower than the frequency of the broadcast waves, but, on the contrary, for example, in the United States, it is upper heterodyne conversion wherein the local oscillation frequency is higher than the frequency of the broadcast waves. Thus, the polarity of the AFC voltage V91 to be supplied to the variable capacitance diode D51 must be made different or inverse between an FM receiver of the lower heterodyne type and another FM receiver of the upper heterodyne type. Accordingly, in the FM receiver of FIG. 3, if it is assumed that lower heterodyne frequency is performed when the AFC voltage V91 and the bias voltage V92 are supplied in such a manner as indicated by solid lines in FIG. 3, then in order to perform upper heterodyne conversion, the AFC voltage V91 and the bias voltage V92 are supplied reversely to that described above to the variable capacitance diode D51 as indicated by broken lines in FIG. 3. Since the relationship between the direction of the heterodyne conversion and the polarity of the AFC voltage V91 naturally applies also to the receiver circuit which is formed into an IC (integrated circuit), such IC for the FM receiver circuit is constructed, for example, in such a manner as shown in FIG. 4. In particular, referring to FIG. 4, circuit elements and connecting lines delineated by a chain line are formed as a one-chip monolithic IC for an FM receiver circuit. The IC shown has external connection terminals T11 to T15 in the form of pins. The resonance circuit 51 is connected to the local oscillation circuit 5 of the IC by way of the terminal T11, and an audio signal from the demodulation circuit 8 of the IC is extracted to the outside of the IC by way of a resistor R81 and the terminal T15 of the IC. Further, the demodulation output S8 of the demodulation circuit 8 is supplied to the low-pass filter 91 which is constituted from the resistor R91 of the IC and the capacitor C91 externally connected to the terminal T14, and the AFC voltage V91 is extracted from the low-pass filter 91. Then, if the elements C92 and R92 are externally connected to the IC as indicated by solid lines, then the AFC voltage V91 from the filter 91 is supplied to the variable capacitance diode D51 by way of the signal line of an invertor 93.fwdarw.a resistor R94.fwdarw.the terminal T13.fwdarw.the resistor R92.fwdarw.the terminal T12 while the bias voltage V92 is supplied to the variable capacitance diode D51. Accordingly, in this instance, the AFC voltage V91 is inverted in polarity by the invertor 93 and then supplied to the variable capacitance diode D51, and consequently, for example, automatic frequency control of the upper heterodyne conversion can be performed. On the other hand, if a resistor R95 is externally connected to the IC in place of the capacitor C92 and the resistor R92 as indicated by a broken line in FIG. 4, then the AFC voltage V91 obtained at the terminal T14 is supplied to the variable capacitance diode D51 by way of the resistor R95 and the terminal T12 while the bias voltage V92 is supplied to the variable capacitance diode D51. Accordingly, in this instance, the AFC voltage V91 is supplied to the variable capacitance diode D51 while maintaining its polarity, and consequently, automatic frequency control of the lower heterodyne conversion can be performed. In this manner, with the AFC circuit 9 of the IC, automatic frequency control of the upper heterodyne conversion can be performed when the elements C91, C92 and R92 are externally connected, but when the elements C91 and R95 are externally connected, automatic frequency conversion of the lower heterodyne conversion can be performed. In summary, the AFC circuit 9 can cope with both of automatic frequency control of the lower heterodyne conversion and automatic frequency control of the upper heterodyne conversion by changing the parts to be externally connected and the positions of the parts. In the case of the AFC circuit 9 of FIG. 4, however, the three terminals T12, T13 and T14, which are used only for automatic frequency control, are required, and consequently, the package of the IC occupies too much space. Also the number of parts to be externally connected is large. Further, when an FM receiver is to be assembled using the IC, the pattern of the printed circuit board must be changed in accordance with the system of heterodyne conversion, that is, the destination of the product. Accordingly, a printed circuit board for lower heterodyne conversion and another printed circuit board for upper heterodyne conversion must necessarily be prepared and maintained in inventory.

[The effect of thyroid- and parathyroidectomy on stress-induced changes in the primary humoral immune response of white rats]. The influence of the immobilization stress (24 h) was studied on male white rats of Wistar strain, examining the primary humoral immune response on the background of thyroid- and parathyroidectomy. It was established that parathyroidectomy induced immunodepression, but the effect of immobilization stress, used just next to immunization with sheep erythrocytes intensified immunodepression. Furthermore application of stress after immunization with sheep erythrocytes (during the effective phase of the immune response) induced immunostimulation. These differences in stress-induced immunological changes could be explained by the peculiarities of neuroendocrine and immunological status during the variants of stress action.

Casey Anthony Video Diary -- I've ADOPTED ... a New Dog Casey Anthony I'VE ADOPTED... 1/5/2012 5:57 AM PST BY TMZ STAFF Casey Anthony has taped a video diary entry that has surfaced on the Internet ... and in the clip, she says she's become a mother ... to a brand new dog. The 4.5 minute video is bizarre ... with Casey sporting a short haircut and glasses ... and rambling about various topics, including how happy she is to be out of jail. In the clip -- which Anthony says was taped on October 13, 2011 -- she says, "I'm extremely excited ... that I'll be able to Skype and obviously keep a video log ... and that I have something that I can finally call mine." She adds, “It’s been a long time since I’ve been able to call something mine.”

Quincy Medical Center goes smoke-free Quincy Medical Center has become a completely smoke-free campus. The teaching hospital had been smoke-free on the inside since 1989, but has decided to extend the ban to the entire property. The Patriot Ledger Quincy Medical Center has become a completely smoke-free campus. The teaching hospital had been smoke-free on the inside since 1989, but has decided to extend the ban to the entire property. “I believe this is the right course to take for our patients, our visitors, our employees and our community,” said Dr. Gary W. Gibbons, president and CEO of QMC. “Quincy Medical Center is dedicated to promoting the health and well-being of its staff, patients and visitors, and smoking goes against everything we do here. We understand that smokers who are affected by this change may need our support and our goal is to help them adapt.” The ban was extended to send the message that smoking is detrimental to health and the leading cause of preventable illnesses and deaths in the United States.

#include <QTableView> #include <QMenu> #include <QHeaderView> #include <QSortFilterProxyModel> #include <QApplication> #include <QSettings> #include "ui_actiontableeditor.h" #include "actiontablemodel.h" #include "actiontableeditor.h" #include "actioneditordialog.h" //start id="setup" ActionTableEditor::ActionTableEditor(QWidget* parent) : QDialog(parent), m_ui(new Ui::ActionTableEditor) { // Designer UI class initialization m_ui->setupUi(this); m_model = new ActionTableModel(allActions(), this); setupSortFilter(); } ActionTableEditor:: ActionTableEditor(QList<QAction*> actions, QWidget* parent) : QDialog(parent) { m_ui->setupUi(this); m_model = new ActionTableModel(actions, this); setupSortFilter(); } QList<QAction*> ActionTableEditor::allActions() { QList<QAction*> actions; foreach (QAction* a, qApp->findChildren<QAction*>()) { if (a->children().size() > 0) continue; if (a->text().size() > 0) actions << a; } foreach (QWidget* w, qApp->topLevelWidgets()) foreach (QAction* a, w->findChildren<QAction*>()) { // skip menus if (qobject_cast<QMenu*>(a->parent()) != 0) continue; if (a->text().size() > 0) actions << a; } return actions; } //start id=dialog void ActionTableEditor:: on_m_tableView_activated(const QModelIndex& idx) { int row = idx.row(); QAction* action = m_model->action(row); ActionEditorDialog aed(action); int result = aed.exec(); if (result == QDialog::Accepted) { QKeySequence ks = aed.keySequence(); m_model->setData(idx, ks.toString()); m_changedActions << action; } } //end //start id=settings void ActionTableEditor::accept() { QSettings s; s.beginGroup("shortcut"); foreach (QAction* act, m_changedActions) { s.setValue(act->text(), act->shortcut() ); } s.endGroup(); QDialog::accept(); } //end void ActionTableEditor::restoreShortcuts(QList<QAction*> actions) { QSettings s; s.beginGroup("shortcut"); foreach (QAction* act, actions) { QVariant v = s.value(act->text(), QVariant()); if (!v.isNull()) { QKeySequence ks = v.value<QKeySequence>(); act->setShortcut(ks); } } s.endGroup(); } //start id="sortfilter" void ActionTableEditor::setupSortFilter() { m_sortFilterProxy = new QSortFilterProxyModel(this); m_sortFilterProxy->setSourceModel(m_model); /* SortFilterProxy source model set to ActionTableModel. */ m_ui->m_tableView->setModel(m_sortFilterProxy); /* Table view model set to proxy model instead of ActionTableModel. */ m_sortFilterProxy->setFilterKeyColumn(-1); /* Filter on all fields. */ } void ActionTableEditor::on_m_filterField_textChanged /* Auto-connected slot. */ (const QString& newText) { m_sortFilterProxy->setFilterFixedString(newText); /* Change the filter string. */ } //end ActionTableEditor::~ActionTableEditor() { delete m_ui; /* the other pointer members are QObject with this as parent */ } void ActionTableEditor::changeEvent(QEvent* e) { QWidget::changeEvent(e); switch (e->type()) { case QEvent::LanguageChange: m_ui->retranslateUi(this); break; default: break; } }

// Code generated by protoc-gen-go. // source: metrics.proto // DO NOT EDIT! /* Package io_prometheus_client is a generated protocol buffer package. It is generated from these files: metrics.proto It has these top-level messages: LabelPair Gauge Counter Quantile Summary Untyped Histogram Bucket Metric MetricFamily */ package io_prometheus_client import proto "github.com/golang/protobuf/proto" import math "math" // Reference imports to suppress errors if they are not otherwise used. var _ = proto.Marshal var _ = math.Inf type MetricType int32 const ( MetricType_COUNTER MetricType = 0 MetricType_GAUGE MetricType = 1 MetricType_SUMMARY MetricType = 2 MetricType_UNTYPED MetricType = 3 MetricType_HISTOGRAM MetricType = 4 ) var MetricType_name = map[int32]string{ 0: "COUNTER", 1: "GAUGE", 2: "SUMMARY", 3: "UNTYPED", 4: "HISTOGRAM", } var MetricType_value = map[string]int32{ "COUNTER": 0, "GAUGE": 1, "SUMMARY": 2, "UNTYPED": 3, "HISTOGRAM": 4, } func (x MetricType) Enum() *MetricType { p := new(MetricType) *p = x return p } func (x MetricType) String() string { return proto.EnumName(MetricType_name, int32(x)) } func (x *MetricType) UnmarshalJSON(data []byte) error { value, err := proto.UnmarshalJSONEnum(MetricType_value, data, "MetricType") if err != nil { return err } *x = MetricType(value) return nil } type LabelPair struct { Name *string `protobuf:"bytes,1,opt,name=name" json:"name,omitempty"` Value *string `protobuf:"bytes,2,opt,name=value" json:"value,omitempty"` XXX_unrecognized []byte `json:"-"` } func (m *LabelPair) Reset() { *m = LabelPair{} } func (m *LabelPair) String() string { return proto.CompactTextString(m) } func (*LabelPair) ProtoMessage() {} func (m *LabelPair) GetName() string { if m != nil && m.Name != nil { return *m.Name } return "" } func (m *LabelPair) GetValue() string { if m != nil && m.Value != nil { return *m.Value } return "" } type Gauge struct { Value *float64 `protobuf:"fixed64,1,opt,name=value" json:"value,omitempty"` XXX_unrecognized []byte `json:"-"` } func (m *Gauge) Reset() { *m = Gauge{} } func (m *Gauge) String() string { return proto.CompactTextString(m) } func (*Gauge) ProtoMessage() {} func (m *Gauge) GetValue() float64 { if m != nil && m.Value != nil { return *m.Value } return 0 } type Counter struct { Value *float64 `protobuf:"fixed64,1,opt,name=value" json:"value,omitempty"` XXX_unrecognized []byte `json:"-"` } func (m *Counter) Reset() { *m = Counter{} } func (m *Counter) String() string { return proto.CompactTextString(m) } func (*Counter) ProtoMessage() {} func (m *Counter) GetValue() float64 { if m != nil && m.Value != nil { return *m.Value } return 0 } type Quantile struct { Quantile *float64 `protobuf:"fixed64,1,opt,name=quantile" json:"quantile,omitempty"` Value *float64 `protobuf:"fixed64,2,opt,name=value" json:"value,omitempty"` XXX_unrecognized []byte `json:"-"` } func (m *Quantile) Reset() { *m = Quantile{} } func (m *Quantile) String() string { return proto.CompactTextString(m) } func (*Quantile) ProtoMessage() {} func (m *Quantile) GetQuantile() float64 { if m != nil && m.Quantile != nil { return *m.Quantile } return 0 } func (m *Quantile) GetValue() float64 { if m != nil && m.Value != nil { return *m.Value } return 0 } type Summary struct { SampleCount *uint64 `protobuf:"varint,1,opt,name=sample_count" json:"sample_count,omitempty"` SampleSum *float64 `protobuf:"fixed64,2,opt,name=sample_sum" json:"sample_sum,omitempty"` Quantile []*Quantile `protobuf:"bytes,3,rep,name=quantile" json:"quantile,omitempty"` XXX_unrecognized []byte `json:"-"` } func (m *Summary) Reset() { *m = Summary{} } func (m *Summary) String() string { return proto.CompactTextString(m) } func (*Summary) ProtoMessage() {} func (m *Summary) GetSampleCount() uint64 { if m != nil && m.SampleCount != nil { return *m.SampleCount } return 0 } func (m *Summary) GetSampleSum() float64 { if m != nil && m.SampleSum != nil { return *m.SampleSum } return 0 } func (m *Summary) GetQuantile() []*Quantile { if m != nil { return m.Quantile } return nil } type Untyped struct { Value *float64 `protobuf:"fixed64,1,opt,name=value" json:"value,omitempty"` XXX_unrecognized []byte `json:"-"` } func (m *Untyped) Reset() { *m = Untyped{} } func (m *Untyped) String() string { return proto.CompactTextString(m) } func (*Untyped) ProtoMessage() {} func (m *Untyped) GetValue() float64 { if m != nil && m.Value != nil { return *m.Value } return 0 } type Histogram struct { SampleCount *uint64 `protobuf:"varint,1,opt,name=sample_count" json:"sample_count,omitempty"` SampleSum *float64 `protobuf:"fixed64,2,opt,name=sample_sum" json:"sample_sum,omitempty"` Bucket []*Bucket `protobuf:"bytes,3,rep,name=bucket" json:"bucket,omitempty"` XXX_unrecognized []byte `json:"-"` } func (m *Histogram) Reset() { *m = Histogram{} } func (m *Histogram) String() string { return proto.CompactTextString(m) } func (*Histogram) ProtoMessage() {} func (m *Histogram) GetSampleCount() uint64 { if m != nil && m.SampleCount != nil { return *m.SampleCount } return 0 } func (m *Histogram) GetSampleSum() float64 { if m != nil && m.SampleSum != nil { return *m.SampleSum } return 0 } func (m *Histogram) GetBucket() []*Bucket { if m != nil { return m.Bucket } return nil } type Bucket struct { CumulativeCount *uint64 `protobuf:"varint,1,opt,name=cumulative_count" json:"cumulative_count,omitempty"` UpperBound *float64 `protobuf:"fixed64,2,opt,name=upper_bound" json:"upper_bound,omitempty"` XXX_unrecognized []byte `json:"-"` } func (m *Bucket) Reset() { *m = Bucket{} } func (m *Bucket) String() string { return proto.CompactTextString(m) } func (*Bucket) ProtoMessage() {} func (m *Bucket) GetCumulativeCount() uint64 { if m != nil && m.CumulativeCount != nil { return *m.CumulativeCount } return 0 } func (m *Bucket) GetUpperBound() float64 { if m != nil && m.UpperBound != nil { return *m.UpperBound } return 0 } type Metric struct { Label []*LabelPair `protobuf:"bytes,1,rep,name=label" json:"label,omitempty"` Gauge *Gauge `protobuf:"bytes,2,opt,name=gauge" json:"gauge,omitempty"` Counter *Counter `protobuf:"bytes,3,opt,name=counter" json:"counter,omitempty"` Summary *Summary `protobuf:"bytes,4,opt,name=summary" json:"summary,omitempty"` Untyped *Untyped `protobuf:"bytes,5,opt,name=untyped" json:"untyped,omitempty"` Histogram *Histogram `protobuf:"bytes,7,opt,name=histogram" json:"histogram,omitempty"` TimestampMs *int64 `protobuf:"varint,6,opt,name=timestamp_ms" json:"timestamp_ms,omitempty"` XXX_unrecognized []byte `json:"-"` } func (m *Metric) Reset() { *m = Metric{} } func (m *Metric) String() string { return proto.CompactTextString(m) } func (*Metric) ProtoMessage() {} func (m *Metric) GetLabel() []*LabelPair { if m != nil { return m.Label } return nil } func (m *Metric) GetGauge() *Gauge { if m != nil { return m.Gauge } return nil } func (m *Metric) GetCounter() *Counter { if m != nil { return m.Counter } return nil } func (m *Metric) GetSummary() *Summary { if m != nil { return m.Summary } return nil } func (m *Metric) GetUntyped() *Untyped { if m != nil { return m.Untyped } return nil } func (m *Metric) GetHistogram() *Histogram { if m != nil { return m.Histogram } return nil } func (m *Metric) GetTimestampMs() int64 { if m != nil && m.TimestampMs != nil { return *m.TimestampMs } return 0 } type MetricFamily struct { Name *string `protobuf:"bytes,1,opt,name=name" json:"name,omitempty"` Help *string `protobuf:"bytes,2,opt,name=help" json:"help,omitempty"` Type *MetricType `protobuf:"varint,3,opt,name=type,enum=io.prometheus.client.MetricType" json:"type,omitempty"` Metric []*Metric `protobuf:"bytes,4,rep,name=metric" json:"metric,omitempty"` XXX_unrecognized []byte `json:"-"` } func (m *MetricFamily) Reset() { *m = MetricFamily{} } func (m *MetricFamily) String() string { return proto.CompactTextString(m) } func (*MetricFamily) ProtoMessage() {} func (m *MetricFamily) GetName() string { if m != nil && m.Name != nil { return *m.Name } return "" } func (m *MetricFamily) GetHelp() string { if m != nil && m.Help != nil { return *m.Help } return "" } func (m *MetricFamily) GetType() MetricType { if m != nil && m.Type != nil { return *m.Type } return MetricType_COUNTER } func (m *MetricFamily) GetMetric() []*Metric { if m != nil { return m.Metric } return nil } func init() { proto.RegisterEnum("io.prometheus.client.MetricType", MetricType_name, MetricType_value) }

Q: Bootstrap toggle tab not working in jsp page I am trying a new web applications and this is the 1st time I am using the Bootstrap and JQuery. I have included the downloaded bootstrap folder under /resources/ folder in my webapp folder of my project. I have also placed the jquery-3.2.0.min.js file like this /resources/bootstrap/js/jquery-3.2.0.min.js The problem is that I am getting the tabs displayed with bootstrap style but when I click on the individual tab's the contents are not getting displayed correctly. Irrespective of what ever tab i click, it will always shows the 1st tab's contents only. Is there any thing wrong in the tags that I am using or do i need to some extra scripting in jQuery? MyJSP page: <%@ taglib uri="http://java.sun.com/jsp/jstl/core" prefix="c" %> <%@ taglib uri="http://www.springframework.org/tags" prefix="spring" %> <%@ taglib uri="http://www.springframework.org/tags/form" prefix="form" %> <%@ page session="false" %> <html lang="en"> <head> <title>Select Questions for Exams</title> <meta charset="utf-8"> <meta name="viewpoint" content="width=device-width, initial-scale=1"> <link rel="stylesheet" href="<%=request.getContextPath()%>/resources/bootstrap/css/bootstrap.min.css"> </head> <body> <h2> Select Exam Questions </h2> <c:url var="addAction" value="/exam/addExam" ></c:url> <form:form action="${addAction}" commandName="examPatternInit"> <c:if test="${!empty questionsMap}"> <div class="container"> <ul class="nav nav-tabs"> <li class="active"><a data-toggle="tab" href="#Test">Test</a></li> <c:forEach items="${questionsMap}" var="subjectEntry"> <li class="nav-item"><a role="tab" data-toggle="tab" href='#<c:out value="${subjectEntry.key}"/>'><c:out value="${subjectEntry.key}"/></a></li> </c:forEach> </ul> <div class="tab-content"> <c:set var="firstTab" value="true"/> <div id='Test' class="tab-pane fade in active"> <h4>Testing Tab</h4> </div> <c:forEach items="${questionsMap}" var="subjectEntryTab"> <div id='<c:out value="${subjectEntryTab.key}"/>' class="tab-pane fade" role="tabpanel"> <c:forEach items="${subjectEntryTab.value}" var="question"> ${question}<br> </c:forEach> </div> </c:forEach> </div> </div> </c:if> </form:form> <br> <script type="text/javascript"> $(document).ready(function(){ $(".nav-tabs a").click(function(){ $(this).tab('show'); }); }); </script> <script src="<%=request.getContextPath()%>/resources/bootstrap/js/jquery-3.2.0.min.js"></script> <script src="<%=request.getContextPath()%>/resources/bootstrap/js/bootstrap.min.js"></script> </body> </html> I am also adding the source code generated for this page( right-click on displayed page and viewing source) just to confirm that the contents of all the tabs are different. view Source: <html lang="en"> <head> <title>Select Questions for Exams</title> <meta charset="utf-8"> <meta name="viewpoint" content="width=device-width, initial-scale=1"> <link rel="stylesheet" href="/spring-mvc-hibernate/resources/bootstrap/css/bootstrap.min.css"> </head> <body> <form id="examPatternInit" action="/spring-mvc-hibernate/exam/addExam" method="post"> <div class="container"> <ul class="nav nav-tabs"> <li class="active"><a data-toggle="tab" href="#Test">Test</a></li> <li class="nav-item"><a role="tab" data-toggle="tab" href='#Computer Science'>Computer Science</a></li> <li class="nav-item"><a role="tab" data-toggle="tab" href='#General Knowledge'>General Knowledge</a></li> </ul> <div class="tab-content"> <div id='Test' class="tab-pane fade in active"> <h4>Testing Tab</h4> </div> <div id='Computer Science' class="tab-pane fade" role="tabpanel"> [Ljava.lang.Object;@1a107bd3<br> [Ljava.lang.Object;@30316703<br> </div> <div id='General Knowledge' class="tab-pane fade" role="tabpanel"> [Ljava.lang.Object;@7b620eac<br> [Ljava.lang.Object;@62b17d7c<br> </div> </div> </div> </form> <br> <script type="text/javascript"> $(document).ready(function(){ $(".nav-tabs a").click(function(){ $(this).tab('show'); }); }); </script> <script src="/spring-mvc-hibernate/resources/bootstrap/js/jquery-3.2.0.min.js"></script> <script src="/spring-mvc-hibernate/resources/bootstrap/js/bootstrap.min.js"></script> </body> </html> </body> </html> Result I am getting: A: id='Computer Science' contain space char. Try with the id that does not contain a space character. The value must not contain any space characters. you can use jstl functions lib. for example; ${fn:replace(subjectEntry.key,' ', '')} this convert into your id ComputerScience. then it might work.

We are also telling teens what to do if they see a bullying video on social media, how parents should react if their child is a victim and we are asking readers to pledge their support to the campaign. Finally we are calling on social media channels to take down any videos showing the bullying of children as soon as they become aware of them. We have pledged not to publish any more videos of children being bullied, unless we have express permission from the family or police. Simon asked us to share one still image from the footage of Toby's attack, to highlight the violence his son was subjected to, but we will not be showing the video. Mercury Press Simon has asked us to share a still grab of the video, to show the violence his son endured The graphic footage showed how Toby was set upon by a gang of thugs who battered him with his own scooter at a local park earlier this year. A group of children gathered round to film as he was beaten and pinned to the floor for "sitting on another lad's bike". Kind Toby had let one youngster have a go on his scooter at their local skate park - but it was then used as a weapon against him Toby's dad said the attack came after years of bullying, by kids who who targeted him "for being ginger". He even says some children picked on his son after his mum and stepmum died within months of one another last year. He said: "Toby's mother died just before Christmas last year and he had some issues after that. There were some people saying horrible things, it made him an easy target. "He's always been bullied because of his hair, but that wears a bit thin now. It was horrible when people were saying things about his mum, they were really close and he Toby was very protective of her - as any boy is with his mum. He would get really upset when people said things, I had to go down to the school to sort it out in the end, and it did stop." The youngster was "too embarrassed" to tell his dad about the filmed attack - meaning Simon actually found out about it when a video began circulating on Snapchat. The aims of the campaign are simple: Firstly: We call on all social media platforms to remove videos of children being physically bullied by other young people as soon as they come to their attention. Secondly: We are asking for Sun readers - both children and adults - to pledge their support to report the videos if they see them. Thirdly: We aim to educate children as to why they should never film and share incidents of bullying and the damage it can cause the victims and to themselves. Fourthly: We want to offer parents an easy step by step guide to help them cope if their children have been victims of cyber bullying. After he was shown the horrific footage by neighbours, Simon decided to share it on Facebook in a bid to raise awareness about the bullying his son was suffering. He said: "I didn't know anything about it until friends came over and showed me the video on their phone. "I'm a single parent with two kids and my first instinct was to go and tear the bullies apart - but they're only 12 and kids fight so obviously that wouldn't be the right thing. "Toby didn't want me to go to the police and I always told him you don't tell tales, you don't grass - so he really didn't want me to." Simon says after sleeping on the matter he decided he couldn't let Toby face school on Monday with everyone talking and laughing about the video - and so took matters into his own hands. He said: "It had already gone round on Snapchat, so all of his friends would have already seen it and would be talking about it. "So I decided to put it on Facebook myself and turn it around, so instead of everyone poking fun at him they were all on his side." Simon wrote a long explanation of what had happened, the bullying Toby had suffered and called on parents and children to stop it happening in the future. How to tackle bullying videos on social media Brutal videos of children beating up other children are becoming more common by the day. But what should you do if you see one pop up on your social media feed? And worse still, what should you do if you discover that your child is a victim of this kind of bullying, or even that they are taking part themselves? It is an incredibly tough position for any parent to be in, so click here for the NSPCC's step by step guide of what to do. While Simon uploaded the video to Facebook himself, he agrees more needs to be done by both social media networks to stop bully videos being taken and widely shared online. He said: "It's a wicked thing, the social media sites should monitor it. There are millions and millions of people using them every day. "I don't know if it would stop the bullying from happening, as that's always been around and no doubt always will be. "But if we can try to teach kids morals and respect, while also stopping these attacks being filmed and shared, it should make a big difference." Simon added it was important to give anyone being bullied the confidence to "tell someone, explain it and stop it happening". The dad, from Yeovil, Somerset, said Toby's school - Prestyn Business Academy - has been "fantastic" since the attack. He praised them for their handling of the situation, but also encouraged schools to work alongside social media platforms and with police to clamp down on the attacks. SWNS:South West News Service Dad Simon uploaded the video on Facebook after it was circulated on Snapchat SWNS:South West News Service Toby and Simon are backing the Sun Online's campaign to stop videos of sick attacks being shared on social media But Simon pointed out there is a risk of also being targeted by bullies outside of school - as was the case with Toby. He said: "I think it's important for schools to work with police and social media - but these attacks aren't just happening at school. "If anything can stop someone from bullying, or teach people there's help available if you do tell people then hopefully it's a move in the right direction." He added: "Adults need to be educated too - you so often hear about teachers saying 'well just pull your socks up and get on with it' - but that's not good enough. "Adults need to be educated so that kids know they are always going to get help if they tell someone about it." If you or anyone you know have experienced this kind of bullying email us at tips@the-sun.co.uk or call 0207 782 4368

29th Illinois General Assembly The 29th Illinois General Assembly was elected in November 1874. The session began on January 6, 1875 and adjourned on April 15, 1875. No party had a majority in either chamber. The Republicans had a plurality in both chambers, with 24 members in the Senate and 69 in the House, but control of the chambers was held by a coalition of Democrats, third parties, and independents. The third parties represented in this session included the Opposition Party, the Independent Reform Party, and the Democratic Liberal Party, which took many of its members (including its leader, former governor John M. Palmer) and positions from the defunct Liberal Republican Party of 1872. All of these parties were organized for the first time in 1874 and disappeared shortly thereafter, their members subsequently becoming Democrats, Greenbackers, or independents. The three-sided tensions between Democrats, Republicans and reformers led to frequent turmoil during the session, including a violent brawl that erupted in the House when Republican Alfred M. Jones threw a book at Democrat Lewis Plater. Partly due to this climate, fewer laws were passed during this session than any session since the 1830s; amounting to only 118 pages. The expenses incurred by this General Assembly were also commensurately lower, at $221,810—less than half the amount incurred by the preceding 28th General Assembly. The 204 members of the 29th Illinois General Assembly are listed in the 1875 Illinois Legislative Manual. Because the Manual is not entirely consistent in its labeling of third-party members of the General Assembly, those identified as "Liberal Republican", "Liberal", or "Democratic Liberal" are counted as a single group in the party totals below. Likewise, the one member of the House labeled simply as "Reform" is treated as a member of the Independent Reform Party for the purpose of the totals. Senate The Illinois Senate as elected in 1874 contained 51 members, one from each state legislative district. Under the Illinois Constitution of 1870, Senators served overlapping 4-year terms; thus, 26 of the senators in the 29th General Assembly were elected in 1874, the remainder having been elected in 1872. They ranged in age from 30 to 65. Democrat Archibald A. Glenn was elected president of the Senate, thereby also taking on the role of acting lieutenant governor. Party composition The Senate of the 29th General Assembly consisted of 24 Republicans, 18 Democrats, and 9 third-party and independent members. Members House of Representatives Under the Illinois Constitution of 1870, the state representatives were elected by cumulative voting, with each voter distributing three votes among the available candidates. The Illinois House of Representatives as elected in 1874 thus contained 153 members, three from each of the state's 51 districts. However, only 152 members were present for the 29th General Assembly, as Robert Thiem of Cook County failed to make an appearance. The members of the House were overwhelmingly new; only 32 of them had previously served in the General Assembly. They ranged in age from 26 to 75; nearly half (72) were farmers. Among the 152 seated members, there were 70 Republicans, 41 Democrats, and 41 independents and reformers. Opposition Party member Elijah Haines was elected Speaker by a coalition of Democrats, independents and reformers, despite lacking the support of some Democrats. Party composition Members See also 44th United States Congress List of Illinois state legislatures Citations References Further reading Laws of the State of Illinois passed by the Twenty-Ninth General Assembly, convened January 6, 1875 Journal of the House of Representatives of the Twenty-Ninth General Assembly of the State of Illinois Category:Illinois legislative sessions Category:Lists of Illinois politicians illinois

Selectivity of quercetin inhibition on stimulated amylase release in rat pancreatic acini. Quercetin (Q) has been shown to inhibit Ca2+-dependent processes. The present study evaluates the effect of Q on amylase release stimulated by various agonists in dispersed rat pancreatic acini. Q inhibited amylase release stimulated by an optimal concentration of carbachol. The inhibition was dependent on Q concentration. Preincubation with Q was not necessary. Maximal inhibition (up to 60% of control) was reached at 50 microM of Q and was completely reversible. Full responsiveness of the acini to agonist stimulation was reestablished as early as 5 min upon the removal of Q. At 50 microM, Q inhibited stimulated amylase release by optimal concentrations of tetradecanoylphorbol-13-acetate (TPA) (10(-6) M), A23187 (3 x 10(-6) M), cholecystokinin C-terminal octapeptide (CCK-OP) (10(-9) M) and carbachol (3 x 10(-6) M), but not by vasoactive intestinal polypeptide (VIP) (3 x 10(-7) M). Instead, Q promoted amylase release stimulated by VIP. The inhibition of amylase secretion by Q occurred only at near optimal, optimal, and supraoptimal concentrations of TPA, A23187, CCK-OP, and carbachol. The potentiation effect of Q on VIP-stimulated amylase secretion was, however, seen at all concentrations of VIP used (10(-8) to 10(-6) M). Quercetin also inhibited protein kinase C activity from rat pancreas in a dose-dependent manner. Maximal inhibition (approximately 85%) was seen at 100 microM of Q. These results provide further support that the intermediary steps for stimulated enzyme secretion in pancreatic acini by TPA, A23187, CCK-OP, and carbachol involve calmodulin and/or protein kinase C, whereas VIP does not.(ABSTRACT TRUNCATED AT 250 WORDS)

.size 8000 .text@100 jp lbegin .data@143 80 .text@150 lbegin: ld a, 03 ldff(43), a ld b, 91 call lwaitly_b ld a, 11 ldff(40), a ld a, 91 ldff(40), a ld b, 9a call lwait_b_ly_cycles ld a, ff ldff(45), a xor a, a ldff(0f), a ld a, 08 ldff(41), a .text@194 ltest_if: ldff a, (0f) cmp a, e0 jrnz lprint_ly xor a, a ldff(0f), a ld c, 18 lwait_nly: dec c jrnz lwait_nly nop nop nop jr ltest_if lprint_ly: ldff a, (44) jp lprint_a .text@7000 lprint_a: push af ld b, 91 call lwaitly_b xor a, a ldff(40), a ld bc, 7a00 ld hl, 8000 ld d, 00 lprint_copytiles: ld a, (bc) inc bc ld(hl++), a dec d jrnz lprint_copytiles pop af ld b, a swap a and a, 0f ld(9800), a ld a, b and a, 0f ld(9801), a ld a, c0 ldff(47), a ld a, 80 ldff(68), a ld a, ff ldff(69), a ldff(69), a ldff(69), a ldff(69), a ldff(69), a ldff(69), a xor a, a ldff(69), a ldff(69), a ldff(43), a ld a, 91 ldff(40), a lprint_limbo: jr lprint_limbo .text@7400 lwaitly_b: ld c, 44 lwaitly_b_loop: ldff a, (c) cmp a, b jrnz lwaitly_b_loop ret .text@7600 lwait_b_ly_cycles: ld c, 1b lwait_b_ly_cycles_wait_nly: dec c jrnz lwait_b_ly_cycles_wait_nly nop dec b jrnz lwait_b_ly_cycles ret .data@7a00 00 00 7f 7f 41 41 41 41 41 41 41 41 41 41 7f 7f 00 00 08 08 08 08 08 08 08 08 08 08 08 08 08 08 00 00 7f 7f 01 01 01 01 7f 7f 40 40 40 40 7f 7f 00 00 7f 7f 01 01 01 01 3f 3f 01 01 01 01 7f 7f 00 00 41 41 41 41 41 41 7f 7f 01 01 01 01 01 01 00 00 7f 7f 40 40 40 40 7e 7e 01 01 01 01 7e 7e 00 00 7f 7f 40 40 40 40 7f 7f 41 41 41 41 7f 7f 00 00 7f 7f 01 01 02 02 04 04 08 08 10 10 10 10 00 00 3e 3e 41 41 41 41 3e 3e 41 41 41 41 3e 3e 00 00 7f 7f 41 41 41 41 7f 7f 01 01 01 01 7f 7f 00 00 08 08 22 22 41 41 7f 7f 41 41 41 41 41 41 00 00 7e 7e 41 41 41 41 7e 7e 41 41 41 41 7e 7e 00 00 3e 3e 41 41 40 40 40 40 40 40 41 41 3e 3e 00 00 7e 7e 41 41 41 41 41 41 41 41 41 41 7e 7e 00 00 7f 7f 40 40 40 40 7f 7f 40 40 40 40 7f 7f 00 00 7f 7f 40 40 40 40 7f 7f 40 40 40 40 40 40

Q: functions.php de wordpress He hecho un plugin para wordpress y ha funcionado, pero parte del código está dentro del functions.php de mi tema hijo y quiero sacarlo, si es posible. En mi functions hay el siguiente código: // llamada para generar sortcode anadir_sortcode(); // función sortcode function anadir_sortcode(){ add_shortcode('ideacook','crea_aviso'); } function crea_aviso(){ //añadimos nuestro script cookie_script.js y acceso a JQuery wp_enqueue_style('estilos', plugins_url().'/coock/includes/estilos.css'); wp_enqueue_script('miscript', plugins_url().'/coock/includes/miscript.js', array('jquery')); ......... ........... ........ } ¿Es posible recolocarlo? ¿dónde? Me gustaría cambiarlo porque el objetivo es simplemente que al instalar el plugin todo funcione y no tenga que tocar nada más. Muchas gracias por su ayuda A: Cree un simple plugin: <?php /** * Plugin Name * * @package PluginPackage * @author Your Name * @copyright 2016 Your Name or Company Name * @license GPL-2.0+ * * @wordpress-plugin * Plugin Name: Plugin Name * Plugin URI: https://example.com/plugin-name * Description: Description of the plugin. * Version: 1.0.0 * Author: Your Name * Author URI: https://example.com * Text Domain: plugin-name * License: GPL-2.0+ * License URI: http://www.gnu.org/licenses/gpl-2.0.txt */ add_action( 'plugins_loaded', 'my_plugin_example_shortcode', 0 ); function my_plugin_example_shortcode(){ add_shortcode('ideacook','crea_aviso'); } function crea_aviso(){ $content = ''; //añadimos nuestro script cookie_script.js y acceso a JQuery wp_enqueue_style('estilos', plugins_url().'/coock/includes/estilos.css'); wp_enqueue_script('miscript', plugins_url().'/coock/includes/miscript.js', array('jquery')); return $content; }

Specific interaction of the Streptomyces chitin-binding protein CHB1 with alpha-chitin--the role of individual tryptophan residues. Streptomyces olivaceoviridis secretes a so far unique protein of 18.7 kDa (CHB1) which lacks catalytic activity. It interacts highly specifically with alpha-chitin, but not with beta-chitin, chitosan, or cellulose. Each of the five codons for tryptophan (Trp) in the chb1 gene was replaced by those for leucine (Leu) or tyrosine (Tyr). Eight corresponding mutant proteins and the wild-type protein were purified to homogeneity and their binding capacity to alpha-chitin was determined. The relative affinities to anti-CHB1 antibodies, the kinetics of binding, the dissociation constants, circular dichroism, and fluorescence emission spectra for three mutant types were compared to the characteristics of CHB1. The presented data lead to the following conclusions. (a) CHBI presents a highly flexible protein lacking alpha-helices. (b) Replacement of each of the buried Trp residues (Trp134 and Trp184) leads to conformational alterations and, in due course, to a considerably reduced binding affinity of the protein. (c) The exchange of the exposed Trp 57 by either Leu or Tyr results in relatively slight topological changes, but entails a loss of binding capacity of about 90%. (d) The dissociation constant was highest for the mutant protein [L57]CHB1 (2.17 microM), followed by [L134]CHB1 (0.91 microM) and [L184]CHB1 (0.26 microM), and lowest for the progenitor CHB1 (0.11 microM), indicating its strong affinity to the unsoluble substrate. (e) The data suggest that the exposed Trp57 contributes directly and significantly to the interaction of CHB1 with alpha-chitin.

Q: How to capitalize Label.text? I have written a program that detects the pressed key and adds the key value to a label. Private Sub Form1_KeyPress(ByVal sender As Object, ByVal e As System.Windows.Forms.KeyPressEventArgs) Handles Me.KeyPress Label23.Text = Label23.Text & e.KeyChar If Label1.Text = Label23.Text Then PictureBox1.Show() End If End Sub The problem is label1 is uppercase (and I can't make it in small letters) and label23 (to which the value is adding) is lowercase. Is there any way in which I can make the value of label as uppercase or make e.KeyChar to add capital letters to the label? A: You need to look at the String.ToUpper() function. Label23.Text = Label23.Text.ToUpper(); There is also the String.ToLower() method. Label23.Text = Label23.Text.ToLower();

The UK’s second (and third, and thereafter) cities don’t often get much of a look in when it comes to attracting Americans – whether visitors or investors. But all that might be about to change with the news that Aloft is preparing quite an aggressive British invasion. If the March 5 opening date still holds, then guests can expect all the usual Aloft accoutrements like funky but comfortable rooms; the w xyz bar and lounge; the re: charge gym; the re: fuel 24-hour pantry for quick bites; free WiFi; and a slightly north of Wall Street location, across from a Pace University campus and about a 15-minute walk to the September 11 Memorial and Museum. However, we wouldn't put all our money into booking a room just yet. The website says the hotel will open on March 5, with reservations being taken for June 5. Eep. In the meantime, there's always the new Residence Inn. Or you know, one of the many other Starwood properties in Manhattan. It’s always great to hear of an endangered landmark that may be saved from the wrecking ball and given back to its city as a hotel. When such salvaging happens in Detroit, it especially thrilling as we are all rooting for Motor City to make a comeback. Here is what we know about the latest effort to turn an abandoned building in Detroit into a hip, hotel (as if there was any other kind.) Brooklyn-based developers ASH NYC have a contract to buy one of the most delapidated, graffiti adorned, buildings in Detroit for conversion to a boutique hotel. The slender 14-story building, pictured above, was once offices and a retail music center for Wurlitzer, the American company acclaimed for its organs and pianos, but who also made jukeboxes and electric guitars. Yes, we're already imagining some of these musical instruments displayed inside the new hotel. A dog is not just for Christmas – it’s for overnight stays in the New Year, too. Or, rather, it is if you’re staying at Aloft Asheville. Its partnership with a local animal rehoming charity means that you can check in petless, and check out with a new furry best friend. Aloft is working with Charlie’s Angels Animal Rescue to rehome pets – which means a beauty parade of doggies around the public areas. Or, rather, one doggy at a time – wearing an “adopt me” vest, and giving pleading eyes to guests at check-in. The “Northern England Hotel Scene” has hitherto not been a phrase that slips easily off the tongue, but the northern cities are killing it this year, with a Beatles hotel, a football hotel and a retro Manhattan hotel all journeying north of the Watford Gap. You’ll find no Beatles murals here. Instead, you get a magnificent conversion of a grand 1903 building which was on English Heritage’s At Risk register, and had been closed for 20 years, before Starwood jumped in and turned it into the UK’s second Aloft. Because of the history, the 116 rooms are pretty much all different (there are 97 room types, according to the Liverpool Echo). All, though, have high ceilings, ‘floating’ beds and Bliss amenities - and "Savvy" rooms have more architectural features, while "Aloft" rooms are more standard. And then those public areas – stained glass windows, wood-paneled conference rooms, and a stucco-roofed lobby. What more could you want? Named for its purpose and state of mind, Botlr, the robotic servant is currently at the tail end of a test run at the Cupertino Aloft in California. We told you all about Botlr last month but in case you need a refresher, here's how he/it works: After receiving a request that needs to be delivered, such as a snack or small amenity, a hotel employee programs the robot by hitting a few buttons. Botlr then uses the hotel Wifi to interact within the hotel and perform tasks, such as calling and directing the elevator to a specific floor. It is programmed with a mapping system that allows it to navigate through the property, the exact same technology used by Google's self-driving cars. Cameras help it avoid obstacles and real people. When it arrives, it uses a signal to call the room telephone and alert the guest. Sensors allow Botlr to recognize when the door is opened and lift the lid on its storage container. And instead of being silently pressured into giving a tip, guests can enter a review for Botlr on its flat panel display screen. If it's a positive review, the Botlr will do a little dance. Well, that solves our problem of not having enough cash on us. We came across a space-themed capsule hotel in China entirely staffed by robots. Way back in 2006, a Sheraton Hotel in Japan unleashed some robots to greet guests. The Hotel @ MIT has a robot on display and of course, we cannot forget about the Yotel luggage robot in Times Square. Yet while these were all innovative additions, with the exception of the Yobot, these hotel robots really didn't fulfill a service need for guests. Until now. The NY Times reports that the Aloft Hotel in Cupertino, across from Apple's headquarters, will start using a Botlr Robot by Silicon Valley start-up Savioke on August 20. (Follow the adventure on social media with the hashtag #MeetBotlr.) The Botlr's mission is simple. It "will shuttle items from the hotel lobby desk to guest rooms." So let's say you've just got settled into room and have changed into your pajamas when you realize that you've forgotten a toothbrush. Instead of going back downstairs or calling housekeeping and waiting forever to have a toothbrush delivered, the Botlr will bring it up to you. Here's how Botlr does what it does: The latest Starwood hotel to hit Miami won't open until March 19, 2015 and judging by the pictures, we're even a little skeptical of that date. Yet it is interesting to see how Aloft is updating the old Motel Arkana, keeping much of the motel's existing structure but also adding another tower adjacent to the lot. (See the rendering on the Aloft Miami Beach website to get a better idea of how it will look.) We knew Starwood had big plans for its health-oriented, eco-conscious Element Hotels brand, with Frankfurt Airport getting the first European outpost on a list that ranges from Flushing, Queens to Muscat, Oman. With Frankfurt opening less than two months from now (September 1, to be exact) comes the news that London will have its very own Element as well, opening in a Boston-esque dual-brand development with an Aloft Hotel in 2017 at the Tobacco Dock area in Wapping, East London. It will be the second Aloft hotel for the city, after Aloft London ExCel further east. Element London Tobacco Dock (the darker brown building on the right above) will have 77 studios, one-bedroom, and two-bedroom suites with kitchens, modular furniture, desks with open shelving, bathrooms with rain showers and dual-flush toilets. We’re hoping the free breakfasts, WiFi, and 24-hour fitness center will make an appearance as well. We first talked about the vintage awesomeness of Terrace Hotel and the gaming paradise of Crown and then the luxury of a Ritz-Carlton, but now even more hotel announcements are coming out of Perth. Australia's fourth largest city is surely the newest hot spot for new properties, major renovations and increased service, but all of this may come at a high price. Room rates in the west coast city are not cheap. On a recent trip with an overnight stop-over in Perth, we searched high and low for an affordable room that wasn't the Bates Motel. Our efforts turned up a room that was close to the airport (we had an early flight) that set us back $250 for the night. The room was basic; the building, prison-like. We weren't impressed and we wondered what was going on with Perth's hotel scene? It takes a long time for a hotel project to go from idea to groundbreaking, from construction to first check-in. So even as we luxuriate (hopefully) in new openings and exciting upgrades, we’re already looking into our crystal ball (AKA the Internet) for buzz on what’s coming down the pipeline. Herewith, we present the three Boston hotel openings in 2015 that have us most excited right now — and why. 1. Envoy Hotel Why we’re excited: Because a hot neighborhood needs a hot hotel. Nothing makes something sound less hip than using the word “hip.” But if you’ll allow us to don our verbal Mom Jeans for a moment — Boston’s Fort Point is hip. It’s hot. It’s very “now,” a little sliver of a neighborhood bordering the Seaport that happens to be filled with some of the most buzz-worthy restaurants in recent years: from legendary chef Barbara Lynch’s fine dining flagship, Menton, to the self-professed “working man’s oyster bar” (if you’re a “working man” in finance, maybe) that is Row 34. Now the transformation from industrial area to hot hospitality ‘hood is nearly complete, with word that the $70 million Envoy Hotel (a rendering shown here) will open in 2015 on Sleeper Street near the Barking Crab restaurant. The six-story property is an entry in Marriott’s luxury Autograph Collection which also includes Maine's upcoming Press Hotel. Expect 136 rooms, plans for a pedestrian plaza that will link to the Boston HarborWalk, a rooftop terrace with skyline and harbor views, and 4,000 square feet of space on the ground level for – what else? – restaurants. Hip. We’re hearing a lot about Aloft Hotels these days and here’s why: Starwood is planning to open 100 Aloft Hotels in 14 countries by the end of 2014. That’s a big shout-out to you, Gen Yers, since Starwood's building 'em mostly for you. So without further adieu, here comes Aloft Calgary University, set to open on April 17—the first Aloft in Western Canada and the third to debut in the country. Like all of the Aloft properties, you can expect modern design, loads of tech, and local live music at its signature W XYZ bar. You’ll also find a 24/7 pantry for when you have the munchies, indoor pool, 24-hour fitness center, full-service day spa, spin studio and a casual eatery on the second level of the hotel. The Aloft Calgary University will have 143 loft-inspired rooms each with a walk-in shower, Bliss toiletries, free and, they’re promising, fast WiFi, and plug & play charging stations that connect to the 42” LCD TV. Rates in May start at $189 CAD, but we say go the distance and have breakfast included for $199 CAD.

Pelleve treats mild to moderate wrinkles, is pain-free and comfortable. Patients report the one-hour treatment feels like a warm massage. The effectiveness lies in the radiofrequency technology, which delivers heat into the deep layers of skin to stimulate the growth of skin-tightening collagen. With a focus on patient safety, and a desire to educate and provide patients with realistic expectations, Dr. Green chose Pelleve because it requires minimal downtime, less care post-treatment, and is less likely than other procedures to cause unwanted side effects, like discoloration. "I've watched the research on this treatment for years, and all the data has been positive. Pelleve fills a specific niche in the suite of facial rejuvenation. It is a good treatment for the reduction of fine lines on the face and it can effectively target areas that are difficult to treat like the nasal-labial folds and fine lines around the mouth, smoker lines on upper lip, crows feet, and laugh lines. It can also be used alone or in combination with other treatments such as surgical lifting procedures or injectables like Botox® and fillers." Dr. Green is excited to offer Pelleve into his practice so that patients could receive a full range of care. He has a more 'ongoing' approach to facial rejuvenation that involves skin care, relaxers like Botox and fillers, and surgical procedures. "I serve to bring only the most effective anti-aging treatments to my patients. Pelleve is an ideal treatment for my practice because of its impeccable safety profile and proven track record of producing results." The Plastic Surgery Office of James Green, MD, is located at The Physician's Plaza, 1631 Hospital Drive, Suite 150 in Santa Fe, New Mexico. (505) 988-2215 About Dr. James Green: In practice for over 20 years in Santa Fe, James Green, MD, is certified by the America Society of Plastic Surgeons and the American Board of Surgery. He has performed thousands of breast implants, breast enlargements/reconstructions, facelifts, tummy tucks, Botox®, Dysport® and Juvaderm® injections, among other cosmetic and reconstructive plastic surgery procedures. About The Pelleve Treatment: Available only through physicians, including dermatologists and plastic surgeons, the Pelleve Wrinkle Reduction System is a proven, effective, safe and painless cosmetic treatment that reduces wrinkles on the face using advanced radiofrequency technology. To view a video of how Pelleve works, please visit: http://www.pelleve.com/science.html

Alexander Litvinenko Alexander Valterovich Litvinenko (; 30 August 1962 or 4 December 1962 by father's account – 23 November 2006) was a British naturalised Russian defector and former officer of the Russian FSB secret service who specialised in tackling organized crime. According to US diplomats, Litvinenko coined the phrase Mafia state. In November 1998, Litvinenko and several other FSB officers publicly accused their superiors of ordering the assassination of the Russian tycoon and oligarch Boris Berezovsky. Litvinenko was arrested the following March on charges of exceeding the authority of his position. He was acquitted in November 1999 but re-arrested before the charges were again dismissed in 2000. He fled with his family to London and was granted asylum in the United Kingdom, where he worked as a journalist, writer and consultant for the British intelligence services. During his time in Boston, Lincoln, Litvinenko wrote two books, Blowing Up Russia: Terror from Within and Lubyanka Criminal Group, wherein he accused the Russian secret services of staging the Russian apartment bombings and other terrorism acts in an effort to bring Vladimir Putin to power. He also accused Putin of ordering the murder in October 2006 of the Russian journalist Anna Politkovskaya. On 1 November 2006, Litvinenko suddenly fell ill and was hospitalised in what was established as a case of poisoning by radioactive polonium-210; he died from the poisoning on 23 November. He became the first known victim of lethal polonium 210-induced acute radiation syndrome. The events leading up to this are a matter of controversy, spawning numerous theories relating to his poisoning and death. A British murder investigation pointed to Andrey Lugovoy, a former member of Russia's Federal Protective Service, as the prime suspect. The United Kingdom demanded that Lugovoy be extradited, which is against the Constitution of Russia, which prohibits extradition of Russian citizens. Russia denied the extradition, which led to the straining of relations between Russia and the United Kingdom. After Litvinenko's death, Marina Litvinenko, aided by biologist Alexander Goldfarb, pursued a vigorous campaign through the Litvinenko Justice Foundation. In October 2011, she won the right for an inquest into her husband's death to be conducted by a coroner in London; the inquest was repeatedly set back by issues relating to examinable evidence. A public inquiry began on 27 January 2015, and concluded in January 2016 that Litvinenko's murder was an FSB operation that was probably personally approved by Vladimir Putin and Nikolai Patrushev who was at the time Director of FSB. Early life and career Alexander Litvinenko was born in the Russian city of Voronezh in 1962. After he graduated from a Nalchik secondary school in 1980, he was drafted into the Internal Troops of the Ministry of Internal Affairs as a Private. After a year of service, he matriculated in the Kirov Higher Command School in Vladikavkaz. In 1981, Litvinenko married Nataliya, an accountant, with whom he had a son, Alexander, and a daughter, Sonia. This marriage ended in divorce in 1994 and in the same year Litvinenko married Marina, a ballroom dancer and fitness instructor, with whom he had a son, Anatoly. After graduation in 1985, Litvinenko became a platoon commander in the Dzerzhinsky Division of the Soviet Ministry of Internal Affairs. He was assigned to the 4th Company of 4th Regiment, where among his duties was the protection of valuable cargo while in transit. In 1986, he became an informant when he was recruited by the MVD's KGB counterintelligence section and in 1988, he was officially transferred to the Third Chief Directorate of the KGB, Military Counter Intelligence. Later that year, after studying for a year at the Novosibirsk Military Counter Intelligence School, he became an operational officer and served in KGB military counterintelligence until 1991. Career in Russian security services In 1991, Litvinenko was promoted to the Central Staff of the Federal Counterintelligence Service, specialising in counter-terrorist activities and infiltration of organised crime. He was awarded the title of "MUR veteran" for operations conducted with the Moscow criminal investigation department, the MUR. Litvinenko also saw active military service in many of the so-called "hot spots" of the former USSR and Russia. During the First Chechen War, Litvinenko planted several FSB agents in Chechnya. Although he was often called a "Russian spy" by western press, throughout his career he was not an 'intelligence agent' and did not deal with secrets beyond information on operations against organised criminal groups. Litvinenko met Boris Berezovsky in 1994 when he took part in investigations into an assassination attempt on the oligarch. He later was responsible for the oligarch's security. Litvinenko's employment under Berezovsky and other security services created a conflict of interest, but such practice is usually tolerated by the Russian state. In 1997, Litvinenko was promoted to the FSB Directorate of Analysis and Suppression of Criminal Groups, with the title of senior operational officer and deputy head of the Seventh Section. Conflict with FSB leadership During his work in the FSB, Litvinenko discovered numerous connections between top brass of Russian law enforcement agencies and Russian mafia groups, such as the Solntsevo gang. He wrote a memorandum about this issue for Boris Yeltsin. Berezovsky arranged a meeting for him with FSB director Mikhail Barsukov and Deputy Director of Internal affairs Ovchinnikov to discuss the corruption problems; however, this had no effect. Litvinenko gradually realized that the entire system was corrupted from the top to the bottom. He explained: "If your partner bilked you, or a creditor did not pay, or a supplier did not deliver - where did you turn to complain? ...When force became a commodity, there was always demand for it. "Roofs" appeared, people who sheltered and protected your business. First it was provided by the mob, then by police, and soon even our own guys realized what was what, and then the rivalry began among gangsters, cops, and the Agency for market share. As the police and the FSB became more competitive, they squeezed the gangs out of the market. However, in many cases competition gave way to cooperation, and the services became gangsters themselves." According to US diplomats, Litvinenko coined the phrase "Mafia state". On 25 July 1998, Berezovsky introduced Litvinenko to Vladimir Putin. He said: "Go see Putin. Make yourself known. See what a great guy we have installed, with your help." On the same day, Putin replaced Nikolay Kovalyov as the Director of the Federal Security Service, with help from Berezovsky. Litvinenko reported to Putin on corruption in the FSB, but Putin was unimpressed. Litvinenko said to his wife after the meeting: "I could see in his eyes that he hated me." Litvinenko said later that he was doing an investigation of Uzbek drug barons who received protection from the FSB, and Putin tried to stall the investigation to save his reputation. On 13 November 1998, Berezovsky wrote an open letter to Putin in Kommersant. He accused senior officers of the Directorate of Analysis and Suppression of Criminal Groups Major-General Yevgeny Khokholkov, N. Stepanov, A. Kamyshnikov, and N. Yenin of ordering his assassination. Four days later, on 17 November, Litvinenko and four other officers appeared together in a press conference at the Russian news agency Interfax. All officers worked for both FSB in the Directorate of Analysis and Suppression of Criminal Groups. They repeated the allegation made by Berezovsky. The officers also said they were ordered to kill Mikhail Trepashkin who was also present at the press conference, and to kidnap a brother of the businessman Umar Dzhabrailov. In 2007, Sergey Dorenko provided the Associated Press and The Wall Street Journal with a complete copy of an interview he conducted in April 1998 for ORT, a television station, with Litvinenko and his fellow employees. The interview, of which only excerpts were broadcast in 1998, shows the FSB officers, who were disguised in masks or dark glasses, claim that their bosses had ordered them to kill, kidnap or frame prominent Russian politicians and business people. After holding the press conference, Litvinenko was dismissed from the FSB. Later, in an interview with Yelena Tregubova, Putin said that he personally ordered the dismissal of Litvinenko, stating, "I fired Litvinenko and disbanded his unit ...because FSB officers should not stage press conferences. This is not their job. And they should not make internal scandals public." Litvinenko also believed that Putin was behind his arrest. He said, "Putin had the power to decide whether to pass my file to the prosecutors or not. He always hated me. And there was a bonus for him: by throwing me to the wolves he distanced himself from Boris [Berezovsky] in the eyes of FSB's generals." Flight from Russia and asylum in the United Kingdom In October 2000, in violation of an order not to leave Moscow, Litvinenko and his family travelled to Turkey, possibly via Ukraine. While in Turkey, Litvinenko applied for asylum at the United States Embassy in Ankara, but his application was denied. With the help of Alexander Goldfarb, Litvinenko bought air tickets for the Istanbul-London-Moscow flight, and asked for political asylum at Heathrow Airport during the transit stop on 1 November 2000. Political asylum was granted on 14 May 2001, not because of his knowledge on intelligence matters, according to Litvinenko, but rather on humanitarian grounds. While in London he became a journalist for Chechenpress and an author. He also joined Berezovsky in campaigning against Putin's government. In October 2006, he became a naturalised British citizen with residence in Whitehaven. In 2002, Litvinenko was convicted in absentia in Russia and given a three-and-a-half-year jail sentence for charges of corruption. According to Litvinenko's widow, Marina Litvinenko, her husband cooperated with the British security services, working as a consultant and helping the agencies to combat Russian organised crime in Europe. During the public inquiry started in January 2015, it was confirmed that Litvinenko was recruited by MI6 to provide "useful information about senior Kremlin figures and their links with Russian organised crime", primarily related to Russian mafia activities in Spain. Shortly before his death, Litvinenko tipped off Spanish authorities on several organised crime bosses with links to Spain. During a meeting in May 2006 he allegedly provided security officials with information on the locations, roles, and activities of several "Russian" mafia figures with ties to Spain, including Zahkar Kalashov, Izguilov and Tariel Oniani. Litvinenko converted to Islam in Britain. Visitors to Litvinenko's deathbed included Boris Berezovsky and Litvinenko's father, Walter, who flew in from Moscow. Litvinenko told his father he had converted to Islam. Mrs Litvinenko said his father commented about it: "It doesn't matter. At least you're not a communist." Mikhail Trepashkin said that in 2002 he had warned Litvinenko that an FSB unit was assigned to assassinate him. In spite of this, Litvinenko often travelled overseas with no security arrangements, and freely mingled with the Russian community in the United Kingdom, and often received journalists at his home. Allegations Litvinenko published a number of allegations about the Russian government, most of which are related to conducting or sponsoring domestic and foreign terrorism. Support of terrorism worldwide by the KGB and FSB Litvinenko stated that "all the bloodiest terrorists of the world" were connected to FSB-KGB, including Carlos "The Jackal" Ramírez, Yasser Arafat, Saddam Hussein, Abdullah Öcalan, Wadie Haddad of the Popular Front for the Liberation of Palestine, George Hawi who led the Communist Party of Lebanon, Ezekias Papaioannou from Cyprus, Sean Garland from Ireland, and many others. He said that all of them were trained, funded, and provided with weapons, explosives and counterfeit documents to carry out terrorist attacks worldwide and that each act of terrorism made by these people was carried out according to the task and under the rigid control of the KGB of the USSR. Litvinenko said that "the center of global terrorism is not in Iraq, Iran, Afghanistan or the Chechen Republic. The terrorism infection creeps away worldwide from the cabinets of the Lubyanka Square and the Kremlin". When asked in an interview who he thought the originator of the 2005 bombings in London was, Litvinenko responded saying, "You know, I have spoken about it earlier and I shall say now, that I know only one organization, which has made terrorism the main tool of solving of political problems. It is the Russian special services." Litvinenko also commented on a new law that "Russia has the right to carry out preemptive strikes on militant bases abroad" and explained that these "preemptive strikes may involve anything except nuclear weapons." Litvinenko said, "You know who they mean when they say 'terrorist bases abroad'? They mean us, Zakayev and Boris and me." He also said that "It was considered in our service that poison is an easier weapon than a pistol." He referred to a secret laboratory in Moscow that still continues development of deadly poisons, according to him. Armenian parliament shooting Litvinenko accused the Main Intelligence Directorate of the General-Staff of the Russian armed forces of having organised the 1999 Armenian parliament shooting that killed the Prime Minister of Armenia, Vazgen Sargsyan, and seven members of parliament, ostensibly to derail the peace process which would have resolved the Nagorno-Karabakh conflict, but he offered no evidence to support the accusation. The Russian embassy in Armenia denied any such involvement, and described Litvinenko's accusation as an attempt to harm relations between Armenia and Russia by people against the democratic reforms in Russia. Russian apartment bombings Litvinenko wrote two books, Lubyanka Criminal Group and Blowing Up Russia: Terror from Within (in co-authorship with historian Yuri Felshtinsky), where he accused the Russian secret services of staging the Russian apartment bombings and other terrorism acts in an effort to bring Vladimir Putin to power. Moscow theatre hostage crisis In a 2003 interview with the Australian SBS TV network, and aired on Dateline, Litvinenko claimed that two of the Chechen terrorists involved in the 2002 Moscow theatre siege—whom he named "Abdul the Bloody" and "Abu Bakar"—were working for the FSB, and that the agency manipulated the rebels into staging the attack. Litvinenko said, "[W]hen they tried to find [Abdul the Bloody and Abu Bakar] among the dead terrorists, they weren't there. The FSB got its agents out. So the FSB agents among Chechens organized the whole thing on FSB orders, and those agents were released." This echoed similar claims made by Mikhail Trepashkin. The leading role of an FSB agent, Khanpasha Terkibaev ("Abu Bakar"), was also described by Anna Politkovskaya, Ivan Rybkin and Alexander Khinshtein. In the beginning of April 2003, Litvinenko gave "the Terkibaev file" to Sergei Yushenkov when he visited London, who in turn passed it to Anna Politkovskaya. A few days later Yushenkov was assassinated. Terkibaev was later killed in Chechnya. According to Ivan Rybkin, a speaker of the Russian State Duma, "The authorities failed to keep [the FSB agent] Terkibaev out of public view, and that is why he was killed. I know how angry people were, because they knew Terkibaev had authorization from presidential administration." Beslan school siege In September 2004, Alexander Litvinenko suggested that the Russian secret services must have been aware of the plot beforehand and probably had organised the attack themselves in order to toughen laws on terrorism and expand the powers of law enforcement agencies. His conclusion was based on the fact that several Beslan hostage takers had been released from FSB custody just before the attack in Beslan. He said that they would have been freed only if they were of use to the FSB, and that even in the case that they were freed without being turned into FSB assets, they would be under strict surveillance that would not have allowed them to carry out the Beslan attack unnoticed. Ella Kesayeva, co-chair of the group Voice of Beslan, supported Litvinenko's argument in a November 2008 article in Novaya Gazeta, noting the large number of hostage takers who were in government custody not long before attacking the school, and coming to the same conclusion. Alleged Russia–al-Qaeda connection In a July 2005 interview with the Polish newspaper Rzeczpospolita, Litvinenko alleged that Ayman al-Zawahiri, a prominent leader of al-Qaeda, was trained for half a year by the FSB in Dagestan in 1997. Litvinenko said that after this training, al-Zawahiri "was transferred to Afghanistan, where he had never been before and where, following the recommendation of his Lubyanka chiefs, he at once ... penetrated the milieu of Osama bin Laden and soon became his assistant in Al Qaeda." Konstantin Preobrazhenskiy, a former KGB officer and writer, supported this claim and said that Litvinenko "was responsible for securing the secrecy of Al-Zawahiri's arrival in Russia; he was trained by FSB instructors in Dagestan, Northern Caucasus, in 1996–1997." He said: "At that time, Litvinenko was the Head of the Subdivision for Internationally Wanted Terrorists of the First Department of the Operative-Inquiry Directorate of the FSB Anti-Terrorist Department. He was ordered to undertake the delicate mission of securing Al-Zawahiri from unintentional disclosure by the Russian police. Though Al-Zawahiri had been brought to Russia by the FSB using a false passport, it was still possible for the police to learn about his arrival and report to Moscow for verification. Such a process could disclose Al-Zawahiri as an FSB collaborator. In order to prevent this, Litvinenko visited a group of highly placed police officers to notify them in advance." According to Sergei Ignatchenko, an FSB spokesman, al-Zawahiri was arrested by Russian authorities in Dagestan in December 1996 and released in May 1997. Assassination of Anna Politkovskaya Two weeks before his poisoning, Alexander Litvinenko accused Vladimir Putin of ordering the assassination of the Russian journalist Anna Politkovskaya and stated that a former presidential candidate, Irina Hakamada, warned Politkovskaya about threats to her life coming from the Russian president. Litvinenko advised Politkovskaya to escape from Russia immediately. Hakamada denied her involvement in passing any specific threats, and said that she warned Politkovskaya only in general terms more than a year earlier. It remains unclear if Litvinenko referred to an earlier statement made by Boris Berezovsky, who claimed that Boris Nemtsov, a former Deputy Prime Minister of Russia, received word from Hakamada that Putin threatened her and like-minded colleagues in person. According to Berezovsky, Putin stated that Hakamada and her colleagues "will take in the head immediately, literally, not figuratively" if they "open the mouth" about the Russian apartment bombings. Allegations concerning Romano Prodi According to Litvinenko, the FSB deputy chief General Anatoly Trofimov said to him, "Don't go to Italy, there are many KGB agents among the politicians. Romano Prodi is our man there," meaning Romano Prodi, the Italian centre-left leader, former Prime Minister of Italy and former President of the European Commission. The conversation with Trofimov took place in 2000, after the Prodi-KGB scandal broke out in October 1999 due to information about Prodi provided by Vasili Mitrokhin. In April 2006, a British Member of the European Parliament for London, Gerard Batten of the United Kingdom Independence Party (UKIP), demanded an inquiry into the allegations. According to the Brussels-based newspaper The EU Reporter on 3 April 2006, "Another high-level source, a former KGB operative in London, has confirmed the story." On 26 April 2006, Batten repeated his call for a parliamentary inquiry, revealing that "former senior members of the KGB are willing to testify in such an investigation, under the right conditions." He added, "It is not acceptable that this situation is unresolved, given the importance of Russia's relations with the European Union." On 22 January 2007, the BBC and ITV News released documents and video footage from February 2006, in which Litvinenko repeated his statements about Prodi. Connections between FSB and mafia In his book Gang from Lubyanka, Litvinenko alleged that Vladimir Putin during his time at the FSB was personally involved in protecting the drug trafficking from Afghanistan organised by Abdul Rashid Dostum. In December 2003, Russian authorities confiscated over 4,000 copies of the book. Shortly before his death, Alexander Litvinenko alleged that Vladimir Putin had cultivated a "good relationship" with Semion Mogilevich (head of the Russia mafia) since 1993 or 1994. Others In an article written by Litvinenko in July 2006, and published online on Zakayev's Chechenpress website, he claimed that Vladimir Putin is a paedophile. Litvinenko also claimed that Anatoly Trofimov and Artyom Borovik knew of the alleged paedophilia. Litvinenko made the allegation after Putin kissed a boy on his stomach while stopping to chat with some tourists during a walk in the Kremlin grounds on 28 June 2006. The incident was recalled in a webcast organised by the BBC and Yandex, in which over 11,000 people asked Putin to explain the act, to which he responded, "He seemed very independent and serious... I wanted to cuddle him like a kitten and it came out in this gesture. He seemed so nice. ... There is nothing behind it." According to Litvinenko, the 2005 controversy over the publication in the Danish newspaper Jyllands-Posten of editorial cartoons depicting the Islamic prophet Muhammad was orchestrated by the FSB to punish Denmark for its refusal to extradite Chechen separatists. Poisoning and death On 1 November 2006, Litvinenko suddenly fell ill. On 3 November, he was admitted to Barnet General Hospital in London. He was then moved to University College Hospital for intensive care. His illness was later attributed to poisoning with radionuclide polonium-210 after the Health Protection Agency found significant amounts of the rare and highly toxic element in his body. Litvinenko met with two former agents early on the day he fell ill – Dmitry Kovtun and Andrei Lugovoy. Though both denied any wrongdoing, a leaked US diplomatic cable revealed that Kovtun had left polonium traces in the house and car he had used in Hamburg. The men also introduced Litvinenko to a tall, thin man of central Asian appearance called 'Vladislav Sokolenko' who Lugovoy said was a business partner. Lugovoy is also a former bodyguard of Russian ex-Acting Prime minister Yegor Gaidar (who also suffered from a mysterious illness in November 2006). Later, Litvinenko had lunch at Itsu, a sushi restaurant in Piccadilly in London, with an Italian acquaintance and nuclear waste expert, Mario Scaramella, to whom he made the allegations regarding Italy's Prime Minister Romano Prodi. Scaramella, attached to the Mitrokhin Commission investigating KGB penetration of Italian politics, claimed to have information on the assassination of Anna Politkovskaya, 48, a journalist who was killed at her Moscow apartment building in October 2006. Marina Litvinenko, his widow, accused Moscow of orchestrating the murder. Though she believes the order did not come from Putin himself, she does believe it was done at the behest of the authorities, and announced that she will refuse to provide evidence to any Russian investigation out of fear that it would be misused or misrepresented. In a court hearing in London in 2015, a Scotland Yard lawyer concluded that "the evidence suggests that the only credible explanation is in one way or another the Russian state is involved in Litvinenko's murder". Death and last statement Before his death, Litvinenko said: "You may succeed in silencing one man but the howl of protest from around the world, Mr. Putin, will reverberate in your ears for the rest of your life." On 22 November 2006, Litvinenko's medical staff at University College Hospital reported Litvinenko had suffered a "major setback" due to either heart failure or an overnight heart attack. He died on 23 November. The following day, Putin publicly stated: “Mr Litvinenko is, unfortunately, not Lazarus”. Scotland Yard stated that inquiries into the circumstances of how Litvinenko became ill would continue. On 24 November 2006, a posthumous statement was released, in which Litvinenko named Putin as the man behind his poisoning. Litvinenko's friend Alex Goldfarb, who was also the chairman of Boris Berezovsky's Civil Liberties Fund, claimed Litvinenko had dictated it to him three days earlier. Andrei Nekrasov said his friend Litvinenko and Litvinenko's lawyer had composed the statement in Russian on 21 November's and translated it to English. Putin disputed the authenticity of this note while attending a Russia-EU summit in Helsinki and claimed it was being used for political purposes. Goldfarb later stated that Litvinenko, on his deathbed, had instructed him to write a note "in good English" in which Putin was to be accused of his poisoning. Goldfarb also stated that he read the note to Litvinenko in English and Russian and Litvinenko agreed "with every word of it" and signed it. His autopsy took place on 1 December at the Royal London Hospital's institute of pathology. It was attended by three physicians, including one chosen by the family and one from the Foreign Office. Litvinenko was buried at Highgate Cemetery (West side) in north London on 7 December. The police treated his death as a murder, although the London coroner's inquest was yet to be completed. On 25 November, two days after Litvinenko's death, an article attributed to him was published by The Mail on Sunday entitled "Why I believe Putin wanted me dead". In an interview with the BBC broadcast on 16 December 2006, Yuri Shvets said that Litvinenko had created a 'due diligence' report investigating the activities of an unnamed senior Kremlin official on behalf of a British company looking to invest "dozens of millions of dollars" in a project in Russia, and that the dossier contained damaging information about the senior Kremlin official. He said he was interviewed about his allegations by Scotland Yard detectives investigating Litvinenko's murder. British media reported that the poisoning and consequent death of Litvinenko was not widely covered in the Russian news media. Funeral On 7 December 2006, Litvinenko was buried at Highgate Cemetery with Muslim rites, including a Muslim prayer being said by an imam who was invited by one of Litvinenko's friends, Akhmed Zakayev, contrary to his wife's wishes of a non-denominational service at the grave. The funeral ceremony was followed by a private memorial at which the ensemble Tonus Peregrinus sang sacred music by Russian composers Igor Stravinsky, Sergei Rachmaninov, Victor Kalinnikov, and three works by British composer Antony Pitts. Investigations into death UK criminal investigation On 20 January 2007, British police announced that they had "identified the man they believe poisoned Alexander Litvinenko. The suspected killer was captured on cameras at Heathrow as he flew into Britain to carry out the murder." The man in question was introduced to Litvinenko as "Vladislav". As of 26 January 2007, British officials said police had solved the murder of Litvinenko. They discovered "a 'hot' teapot at London's Millennium Hotel with an off-the-charts reading for polonium-210, the radioactive material used in the killing." In addition, a senior official said investigators had concluded the murder of Litvinenko was "a 'state-sponsored' assassination orchestrated by Russian security services." The police want to charge former Russian spy Andrei Lugovoy, who met Litvinenko on 1 November 2006, the day officials believe the lethal dose of polonium-210 was administered. On the same day, The Guardian reported that the British government was preparing an extradition request asking that Andrei Lugovoy be returned to the UK to stand trial for Litvinenko's murder. On 22 May 2007, the Crown Prosecution Service called for the extradition of Russian citizen Andrei Lugovoy to the UK on charges of murder. Lugovoy dismissed the claims against him as "politically motivated" and said he did not kill Litvinenko. A British police investigation resulted in several suspects for the murder, but in May 2007, the British Director of Public Prosecutions, Ken Macdonald, announced that his government would seek to extradite Andrei Lugovoy, the chief suspect in the case, from Russia. On 28 May 2007, the British Foreign Office officially submitted a request to the Government of Russia for the extradition of Lugovoy to face criminal charges in the UK. On 2 October 2011, The Sunday Times published an article wherein the chief prosecutor who investigated the murder of Litvinenko, Lord Macdonald of River Glaven, publicly spoke of his suspicion that the murder was a "state directed execution" carried out by Russia. Until that time, British public officials had stopped short of directly accusing Russia of involvement in the poisoning. "It had all the hallmarks of a state directed execution, committed on the streets of London by a foreign government," Macdonald added. In January 2015, it was reported in the UK media that the National Security Agency had intercepted communications between Russian government agents in Moscow and those who carried out what was called a "state execution" in London: the recorded conversations allegedly proved that the Russian government was involved in Litvinenko's murder, and suggested that the motive was Litvinenko's revelations about Vladimir Putin's links with the criminal underworld. On 21 January 2016, the Home Office published The Litvinenko Inquiry: Report into Litvinenko's death. Russian criminal investigation Many publications in Russian media suggested that the death of Alexander Litvinenko was connected to Boris Berezovsky. Former FSB chief Nikolay Kovalyov, for whom Litvinenko worked, said that the incident "looks like the hand of Boris Berezovsky. I am sure that no kind of intelligence services participated." This involvement of Berezovsky was alleged by numerous Russian television shows. Kremlin supporters saw it as a conspiracy to smear the Russian government's reputation by engineering a spectacular murder of a Russian dissident abroad. After Litvinenko's death, traces of polonium-210 were found in an office of Berezovsky. Litvinenko had visited Berezovsky's office as well as many other places in the hours after his poisoning. The British Health Protection Agency made extensive efforts to ensure that locations Litvinenko visited and anyone who had contact with Litvinenko after his poisoning, were not at risk. Russian prosecutors were not allowed to investigate the office. Russian authorities have also been unable to question Berezovsky. The Foreign Ministry complained that Britain was obstructing its attempt to send prosecutors to London to interview more than 100 people, including Berezovsky. On 5 July 2007, Russia officially declined to extradite Lugovoy, citing Article 61 of the Constitution of Russia that prohibits extradition of citizens. Russia has said that they could take on the case themselves if Britain provided evidence against Lugovoy but Britain has not handed over any evidence. The head of the investigating committee at the General Prosecutor's Office said Russia has not yet received any evidence from Britain on Lugovoy. "We have not received any evidence from London of Lugovoy's guilt, and those documents we have are full of blank spaces and contradictions. However, the British ambassador to Russia, Anne Pringle, claimed that London has already submitted sufficient evidence to extradite him to Britain. Judicial inquiries Inquest in London On 13 October 2011, Dr. Andrew Reid, the Coroner of St. Pancras, announced that he would hold an inquest into Litvinenko's death, which would include the examination of all existing theories of the murder, including possible complicity of the Russian government. The inquest, held by Sir Robert Owen, a High Court judge acting as the coroner, originally scheduled to start on 1 May 2013, was subject to a series of pre-hearings: firstly, the coroner agreed that a group representing Russian state prosecutors could be accepted as a party to the inquest process; secondly, the British Government submitted a Public Interest Immunity (PII) certificate. Under Public Interest Immunity (PII) claims, the information at the disposal of the UK government relating to Russian state involvement, as well as how much British intelligence services could have done to prevent the death, would be excluded from the inquest. On 12 July 2013, Sir Robert, who had previously agreed to exclude certain material from the inquest on the grounds its disclosure could be damaging to national security, announced that the British Government refused the request he had made earlier in June to replace the inquest with a public inquiry, which would have powers to consider secret evidence. After the hearing, Alex Goldfarb said: "There's some sort of collusion behind the scenes with Her Majesty's government and the Kremlin to obstruct justice"; Elena Tsirlina, Mrs Litvinenko's solicitor, concurred with him. On 22 July 2014, the UK Home Secretary Theresa May, who had previously ruled out an inquiry on the grounds it might damage the country's relations with Moscow, announced a public inquiry into Litvinenko's death. The inquiry was chaired by Sir Robert Owen who was the Coroner in the inquest into Litvinenko's death; its remit stipulated that "the inquiry will not address the question of whether the UK authorities could or should have taken steps which would have prevented the death". The inquiry started on 27 January 2015. New evidence emerged at first hearings held at the end of January 2015. The last day of hearings was on 31 July 2015. The inquiry report was released on 21 January 2016. The report found that Litvinenko was killed by two Russian agents, Andrei Lugovoi and Dmitry Kovtun and that there was a "strong probability" they were acting on behalf of the Russian FSB secret service. Paragraph 10.6 of the report stated: "The FSB operation to kill Mr Litvinenko was probably approved by Mr Patrushev and also by President Putin." The Report outlined five possible motives for the murder: a belief Litvinenko had betrayed the FSB through public disclosures about its work; a belief that he was working for British intelligence; because he was a prominent associate of leading opponents of Mr Putin and his regime, including Mr Boris Berezovsky and Akhmed Zakayev; because his claims about the FSB were "areas of particular sensitivity to the Putin administration", including a plot to murder dissident Boris Berezovsky; and because there was “undoubtedly a personal dimension to the antagonism" between Litvinenko and Putin, culminating in his allegation that Putin was a paedophile. On the release of the report, British Prime Minister David Cameron condemned Putin for presiding over "state sponsored murder". British Labour MP Ian Austin said: "Putin is an unreconstructed KGB thug and gangster who murders his opponents in Russia and, as we know, on the streets of London—and nothing announced today is going to make the blindest bit of difference." The Kremlin dismissed the Inquiry as "a joke" and "whitewash". The same day, British Home Secretary Theresa May announced that assets belonging to both Lugovoi and Kovtun would be immediately frozen and that the Metropolitan Police were seeking their extradition. The Russian Ambassador was also summoned by the British Foreign Secretary Philip Hammond and demands were made that Russia cooperate with the investigation into Mr Litvinenko's murder with Foreign Office minister David Liddington asserting that Russia had demonstrated "a flagrant disregard for UK law, international law and standards of conduct, and the safety of UK citizens" However, the government's response to the inquiry's results has been described by The Economist as consisting of "tough talk and little action". Litvinenko vs. the Russian Federation in Strasbourg In May 2007, Marina Litvinenko registered a complaint against the Russian Federation in the European Court of Human Rights in Strasbourg, accusing the Russian state of violating her husband's right to life, and failing to conduct a full investigation. In popular culture Rebellion: the Litvinenko Case is a documentary about Litvinenko's activities and death. The Litvinenko Project is a live-performance devised by 2Magpies Theatre (Nottingham, UK) exploring the possibilities which lead to Litvinenko's poisoning An episode of BuzzFeed Unsolved aired about his death in August 2018. An opera The Life & Death of Alexander Litvinenko by Anthony Bolton, libretto Kit Hesketh-Harvey. World premiere 16 July 2020 at Grange Park Opera. His death is mockingly referenced in the first episode of series nine of the British television sitcom Peep Show: Jeremy: What about going... Litvinenko? Mark: Kill him? With polonium? Jeremy: Not full Litvinenko... See also Poisoning of Sergei and Yulia Skripal References His books Alexander Litvinenko, Yuri Felshtinsky, "Blowing Up Russia: The Secret Plot to Bring Back KGB Terror" Encounter Books, New York, 2007 Yuri Felshtinsky, Alexander Litvinenko, and Geoffrey Andrews. Blowing up Russia: Terror from within Gibson Square Books, London, 2007, Alexander Litvinenko: "Allegations – Selected Works by Alexander Litvinenko", translated from Russian and edited by Pavel Stroilov, introduction by Vladimir Bukovsky, Publisher: Aquilion (12 November 2007), A. Litvinenko and A. Goldfarb. Criminal gang from Lubyanka GRANI, New York, 2002, А. Литвиненко Лубянская преступная группировка GRANI, New York, 2002, A documentary film, Assassination of Russia was made by French producers based on books by Litvinenko. He was a consultant for the movie. Books and films about him Boris Volodarsky. The KGB's Poison Factory: From Lenin to Litvinenko, Pen & Sword/Frontline Books, 2009. Alan Cowell. The Terminal Spy: A True Story of Espionage, Betrayal and Murder, Random House, 2008. William Dunkerley. The Phony Litvinenko Murder, Omnicom Press, 2011. Alex Goldfarb and Marina Litvinenko. Death of a Dissident: The Poisoning of Alexander Litvinenko and the Return of the KGB. Free Press, New York, 2007. . Luke Harding. A Very Expensive Poison: The Assassination of Alexander Litvinenko and Putin's War with the West, Vintage Books, 2017. Martin Sixsmith. The Litvinenko File: the True Story of a Death Foretold, Publisher: Macmillan (2 April 2007) Andrei Nekrasov. Rebellion: the Litvinenko Case, 2007, Dreamscanner. Banned in Russia. Official site: https://web.archive.org/web/20080415151727/http://www.dreamscanner-productions.com/litvinenko/index.html External links Litvinenko Justice Foundation Alexander Litvinenko at the Frontline Club accusing Vladimir Putin of the assassination of journalist Anna Politkovskaya (In Russian and English) Litvinenko Inquest (official site) Category:1962 births Category:2006 deaths Category:People from Voronezh Category:Assassinated British people Category:Assassinated Russian people Category:Burials at Highgate Cemetery Category:Converts to Islam Category:Russian political writers Category:Deaths by poisoning Category:Espionage scandals and incidents Category:FSB officers Category:KGB officers Category:Murdered male writers Category:People murdered in London Category:People of the Chechen wars Category:Russian emigrants to the United Kingdom Category:Russian people murdered abroad Category:Russian political activists Category:Unsolved murders in London Category:Victims of radiological poisoning Category:Secret Intelligence Service Category:Russian murder victims Category:Russian Muslims Category:British Muslims Category:Nuclear terrorism

The relationship between pulse waveform analysis indices, endothelial function and clinical outcomes in patients with peripheral artery disease treated using percutaneous transluminal angioplasty during a one-year follow-up period. The aim of the current study was to assess the relationship between potential predictors of clinical outcomes after percutaneous transluminal angioplasty (PTA) of peripheral arteries during a one-year follow-up. Indices of endothelial function (EF), arterial pulse waveform analysis (aPWA) and markers of peripheral arteries ischemia were among those mostly examined. The study comprised of 72 individuals with PAD who underwent PTA of the peripheral arteries. During the first visit and 1 and 6 months after PTA, endothelial function and aPWA measurements were performed. Ankle-brachial index (ABI), toe-brachial index (TBI) and physical evaluation of the limbs took place during the first visit and 1, 6 and 12 months after the PTA. The study endpoints included myocardial infarction, amputation, death, stroke and reintervention. All subjects included into the study were observed for 386 days after the PTA. We noticed significant improvement in walking distance after PTA, as well as transient improvement of ABI and flow-mediated dilatation (FMD), and no significant changes in aPWA indices or reactive-hyperemia index (RHI). There were 25 study endpoints which occurred in 16 patients during the follow-up period (22.2%). Patients with CLI, hypercholesterolemia, lower diastolic blood pressure, higher subendocardial viability ratio, greater number of pack-years and lower TBI at baseline presented significantly poorer clinical outcomes in terms of endpoint events. Endothelial function assessed as FMD and RH-PAT before PTA in patients with advanced PAD does not predict clinical outcomes during the one-year follow-up. < p > < /p >.

Q: How to delete unused IDC_* entries from AppResourceId.h When I rename IDs of controls in Native UI Builder, old names are left unused. Is there any convenient way to eliminate these cluttered unused constants? A: Just delete the names from the AppResourceId.h and also from AppResourceId.cppif there's the definition of the same, It wont do any harm.

Gil Brandt takes a closer look at the rosters of the seven teams that will have new coaches at the helm for the 2014 season. READ The newest coach of the Detroit Lions quoted the Bible and an ancient Chinese proverb during his introductory press conference on Wednesday. At one point, he asked the media members in attendance, "Do you believe in providence?" Caldwell does. He believes he was brought to Detroit to bring the Lions their first Super Bowl championship. Caldwell's task is no simple one: He must instill a sense of discipline, maximize the potential of a talented-but-flawed quarterback and make fans forget he was the second (or perhaps third) choice for the job. Most importantly, he must build a consistent winner. He'll get far less time to do so than his predecessor, Jim Schwartz. "We're going to be smart," Caldwell said. "We're going to be a football team that takes the field, that's not going to shoot itself in the foot." The Lions went 11-21 over the past two seasons. That's fairly grisly, though you won't find many people who will argue the team is -- or should be -- rebuilding. Caldwell knows it. "Every single one of them, to a man, are excited about the opportunity they have presented before them, and I think that without question they're willing to do whatever it takes to win," he said. "They believe, and I believe, the time is now. Not two years or three years from now, down the road somewhere, but right here, right now." Call it providence, luck or simple circumstance, but Caldwell has landed in an enviable spot. He inherits a talented team that plays in a mediocre division. Caldwell is going to get a real shot of making the most of his second opportunity.

585 S.W.2d 678 (1979) The STANDARD FIRE INSURANCE COMPANY, Petitioner, v. Christy Jean Wand LaCOKE, Respondent. No. B-8203. Supreme Court of Texas. July 25, 1979. Rehearing Denied September 19, 1979. *679 Bailey, Williams, Westfall, Lee & Fowler, C. Edward Fowler, Jr. and Stephen G. Koerner, Dallas, for petitioner. Law Offices of Windle Turley, Larry D. Morris and Larry Hayes, Dallas, for respondent. JOHNSON, Justice. The question presented for our decision in this case is whether a petition filed one day late should be deemed to be timely filed when the undisputed cause of the delay was the act of a deputy district clerk. After trial to a jury, the trial court rendered judgment on the verdict dismissing Standard Fire Insurance's cause for want of jurisdiction and granting Christy Jean Wand LaCoke judgment on her suit to mature the award of the Industrial Accident Board. The court of civil appeals, with one member concurring and one dissenting, affirmed. 574 S.W.2d 802. We reverse the judgments of the trial court and the court of civil appeals and remand this cause for a new trial. The Industrial Accident Board rendered its decision awarding LaCoke approximately $21,000 as compensation for work-related injuries on May 7, 1976. Standard Fire was required by statute to notify the Board of its intention to appeal the award within twenty days from the date thereof. Tex. Rev.Civ.Stat.Ann. art. 8307, § 5.[1] Standard Fire filed notice with the Board on May 14, well within the twenty-day period. The same statute further required that Standard Fire bring suit to set aside the award within twenty days after giving its notice of appeal, making June 3, 1976 the last day on which Standard Fire could file its petition. Standard Fire's original petition was file-marked in the district clerk's office at 7:51 a. m. on June 4, 1976, one day late. The reasons for the delay are undisputed. All mail for the Dallas County Courthouse complex is routed through a United States post office substation, known as the VIM Room. The VIM Room is located in the Dallas County Records Building, which is one block away from the district clerk's office. The VIM Room post office in 1976 had a policy of making two mail deliveries per day, one at 8:30 a. m. and the other at 11:00 a. m. Standard Fire's petition, which *680 was contained in a properly stamped and addressed envelope, arrived at the VIM room on June 3 after the 8:30 a. m. mail delivery but in time for the 11:00 a. m. second delivery. In the normal course of affairs the VIM Room postman would have delivered the petition to the clerk's office by noon on June 3, and it would have been timely filed. Unknown to Standard Fire or the district clerk, however, a deputy district clerk had instructed the postman not to deliver the second mail. Instead, the deputy district clerk would go to the VIM Room the following morning, before the regularly scheduled first mail delivery at 8:30 a. m., and pick up the previous day's undelivered mail. This practice had been going on for two years without the knowledge or consent of the district clerk. As a consequence, Standard Fire's petition, which was in the VIM Room on June 3, was delayed one day, until June 4, at which time it was picked up by the deputy district clerk and filed. The district clerk first learned of this practice as a result of the instant case, whereupon he promptly requested the post office to resume making both regularly scheduled deliveries. It is undisputed that the only reason the post office ceased delivering the second mail was because of the deputy district clerk's request that it do so. In the words of the postman himself: "Two deliveries a day are available, and I normally do make two deliveries daily to the county offices, except for those who do not want a second delivery. The only reason that I do not deliver mail twice a day to the District Clerk's office is that they [i. e., the deputy district clerk] do not want this service." The rule is firmly established that the twenty-day period for filing a petition is mandatory and jurisdictional. Failure to file within the statutory period leaves the court without jurisdiction over the case. Clawson v. Texas Employers Insurance Ass'n, 475 S.W.2d 735, 737-38 (Tex.1972); Richards v. Consolidated Underwriters, 411 S.W.2d 436 (Tex.Civ.App.-Beaumont 1967, writ ref'd); Oilmen's Reciprocal Ass'n. v. Franklin, 116 Tex. 59, 286 S.W. 195 (1926); Mingus v. Wadley, 115 Tex. 551, 285 S.W. 1084 (1926). This court has only recently had occasion to reconsider the strictness of the twenty-day period as it relates to giving notice of intention to appeal to the Industrial Accident Board. Ward v. Charter Oak Fire Insurance Co., 579 S.W.2d 909 (Tex. 1979). Ward relaxed the strictness of the rule by applying a notice provision similar to that found in Rule 5 of the Texas Rules of Civil Procedure. There is no need to adopt the Ward approach in the case at bar. The question in this case, as we see it, is simply whether or not Standard Fire's petition was timely filed. A civil suit in the district or county court is commenced by a petition filed in the office of the clerk. Tex.R.Civ.P. 22. The Rules of Civil Procedure provide that "the filing of pleadings ... shall be made by filing them with the clerk of the court," with an exception not here relevant. Tex.R.Civ.P. 74. The rule is traditionally stated to be that an instrument is deemed in law filed at the time it is left with the clerk, regardless of whether or not a file mark is placed on the instrument and regardless of whether the file mark gives some other date of filing. Turner v. State, 41 Tex. 549 (1874); Holman v. Chevaillier, 14 Tex. 337 (1855); Beal v. Alexander, 6 Tex. 531 (1855). See Hughes v. Atlantic Refining Company, 424 S.W.2d 622 (Tex. 1968); Consolidated Furniture Company v. Kelly, 366 S.W.2d 922 (Tex.1963); Hanover Fire Ins. Co. v. Shrader, 89 Tex. 35, 33 S.W. 112 (1895); 2 R. McDonald, Texas Civil Practice, § 5.20 (1970); 5 Baylor L. Rev. 67 (1952). The purpose of this rule is to protect a diligent party from being penalized by the errors and omissions of the court clerk. For example, it has been held that a file mark on a document dated two days after the date of judgment would be ignored when the judgment contained a recital that the document was part of the record and properly before the court. Lessing v. Gilbert, 8 Tex.Civ.App. 174, 27 S.W. 751 (1894, no writ). As relevant to this case, there have *681 been instances where the jury was called upon to decide whether the clerk's file mark was accurate or whether the petition in question actually was filed with the clerk within the twenty days prescribed by law. Kirby v. Travelers Insurance Co., 370 S.W.2d 912 (Tex.Civ.App.-Beaumont 1953, writ ref'd n. r. e.); Texas Indemnity Ins. Co. v. Williamson, 109 S.W.2d 322 (Tex.Civ. App.-El Paso 1937, writ dism'd). In a related vein, this court has held clerks subject to writs of mandamus for their refusal to transmit applications for writ of error to this court because they believed the cases were without merit, against indicating that the substantive rights of a party may not be thwarted by the misconduct of a clerk. Wagner v. Garrett, 114 Tex. 362, 269 S.W. 1030 (1925); Reeves v. Roseborough, 114 Tex. 344, 267 S.W. 973 (1925). More recently, this court has stated that an instrument is deemed filed when it is placed in the custody or control of the clerk. Glidden Company v. Aetna Casualty & Surety Company, 155 Tex. 591, 291 S.W.2d 315 (1956). In Gonzalez v. Vaello, 91 S.W.2d 904 (Tex.Civ.App.-San Antonio 1936, writ dism'd), the clerk was absent from his office so the plaintiff placed his petition in a mail box in the clerk's office. Although the plaintiff did this within the prescribed time limits, the petition was not filed by the clerk until two days after time had run. The court of civil appeals there held that the petition was timely filed inasmuch as the plaintiff had done all he could to timely file the instrument, the instrument was within the custody and control of the clerk, and since any delay was due to the absence of the clerk. There can be no doubt that Standard Fire's petition in this case was within the effective control of the deputy district clerk, even though it was not within his actual physical possession. The petition would have been delivered to the clerk's office on time but for the act of the deputy district clerk, this conclusion is made more compelling by consideration of a slightly altered state of facts. Assume that the deputy district clerk had instructed the post office to stop delivering mail for an entire week and that the post office complied with this request. It could not seriously be contended that the affected parties should be penalized for the clerk's actions. Standard Fire's position is no different in principle than the hypothetical example we pose. Consequently, we hold that Standard Fire's petition should be deemed in law to be timely filed. We reject as inapplicable LaCoke's argument that Standard Fire, having chosen the post office as its agent for delivery, should be bound by any delays caused by the post office. The cause of the delay was the deputy district clerk, not the post office. Cf. Ward v. Charter Oak Fire Insurance Co., supra, 579 S.W.2d at 910. We further reject LaCoke's argument that our holding today will impose some new duty on the clerk to check the post office continuously each day so as to retrieve and file any late-arriving mail. The duty imposed on the clerk is one under which he already operates: to file such papers as are tendered for filing and to place no obstruction in the paths of parties attempting to file same. See Tex.R.Civ.P. 24. The judgments of the court of civil appeals and the trial court are reversed. This cause is remanded to the trial court for trial on the merits. NOTES [1] The relevant portions of Section 5 are as follows: "Any interested party who is not willing and does not consent to abide by the final ruling and decision of said Board shall, within twenty (20) days after the rendition of said final ruling and decision by said Board, file with said Board notice that he will not abide by said final ruling and decision. And he shall within twenty (20) days after giving such notice bring suit in the county where the injury occurred to set aside said final ruling and decision, and said Board shall proceed no further toward the adjustment of such claim, other than hereinafter provided. ". . . "If any party to such final ruling and decision of the Board, after having given notice as above provided, fails within said twenty (20) days to institute and prosecute a suit to set the same aside, then said final ruling and decision shall be binding upon all parties thereto; and, if the same is against the Association, it shall at once comply with such final ruling and decision; and failing to do so, the Board shall certify the fact to the Commissioner of Insurance, and such certificate shall be sufficient cause to justify said Commissioner to revoke or forfeit the license or permit of such Association to do business in Texas."

Sheriff of Lanark The Sheriff of Lanark or Sheriff of Lanarkshire was historically the royal official responsible for enforcing law and order and bringing criminals to justice in Lanarkshire, Scotland. Prior to 1748 most sheriffdoms were held on a hereditary basis. From that date, following the Jacobite uprising of 1745, the hereditary sheriffs were replaced by salaried sheriff-deputes, qualified advocates who were members of the Scottish Bar. The sheriffdom of Lanarkshire was dissolved in 1975 when it was replaced by the current sheriffdom of South Strathclyde, Dumfries and Galloway. Sheriffs of Lanarkshire Baldwin of Biggar (1154) Waldeve of Biggar (1170s) William de Hertisheved (1225) Richard de Coulter (1226) Alexander Uvieth (Oviot) (1266) Nicholas de Biggar (1273-1278) Hugh de Dalzell (1288-1290) Hugh de Balliol (1290) Henry St Clair (1293) Andrew Livingstone (1295-1296) William Heselrig (1296-1297)(assassinated by William Wallace) Walter Logan (1301) Walter Burdon (1302) Robert de Brus (1303) Magnus de Stratherne - 1303 - Deputy Nicholas de Benhathe - 1303 - Deputy Henry St Clair (1305) William Fleming Robert de Barde (1329) William Douglas (c. 1345) William Livingston (1359) Robert Dalzell (1360) James Lindsay (1373) Hugh Aldistoun - 1373 - Deputy William Newbyggyng (1387) William Somerville - 1387 - Deputy Thomas Fitzmartin - 1387 - Deputy James Douglas of Bavany (1432) Hugh Douglas, Earl of Ormonde (1454) James Hamilton, 1st Lord Hamilton (1470) Archibald Douglas, 5th Earl of Angus (1489) James Livingstone John Speddy (c. 1552) William Douglas, Duke of Hamilton (1683) Sheriffs-Depute (1748) Robert Sinclair, 1775–1786 Sir William Honyman, 1st Baronet, 1786–1797 Robert Hamilton, 1797–1822 William Rose Robinson, 1822–1834 Archibald Alison, 1834–1867 Henry Glassford Bell, 1867–1874 William Gillespie Dickson, 1874–1876 Francis William Clark, 1876–1886 Robert Berry, 1886–1903 William Guthrie, 1903– Alastair Oswald Morison Mackenzie, 1917-1933 Sir Archibald Campbell Black, KC, 1937– Sir Allan Grierson Walker, QC, 1963–74 Sheriffdom replaced in 1975 by the sheriffdom of South Strathclyde, Dumfries and Galloway. See also Historical development of Scottish sheriffdoms References * Category:Lanark

When Archive Slippery When Wet (OSR/d6) This module for the Alpha Blue RPG clocks in at 15 pages, 1 page front cover, 1 page editorial, leaving us with 13 pages of content, so let’s take a look! At this point, I expect you’re familiar with Alpha Blue – it’s a RPG designed in the vein of 70s and 80s scifi-porn-parodies and thus contains copious amounts of sleaze and associated themes. I covered all three big supplements for it, so if you’re not familiar with the game or unsure whether this is for you, take a look at the respective reviews. Rules-wise, we have a variant of the VSD6-engine, so if you’re familiar with Venger’s “The Outer Presence” or “Crimson Dragon Slayer”-games, […] Mini-Dungeon: When Goblins die, no Comets are seen This pdf clocks in at 2 pages and is a mini-dungeon. This means we get 2 pages content, including a solid map and all item/monster-stats hyperlinked and thus, absent from the pdf, with only deviations from the statblocks being noted for the GM. Oh, and the series now comes in an archive that also contains…*drumroll* a .jpg-version of the map! Yeah, that’s pretty amazing! Better yet: GM-friendly version of the jpg’s included as well! Since this product line’s goal is providing short diversions, side-quest dungeons etc., I will not expect mind-shattering revelations, massive plots or particularly smart or detailed depictions, instead tackling the line for what it is. Got that? Great! […]

Specificity of EIA immunoassay for complement factor Bb testing. During the alternative complement pathway activation, factor B is cleaved in two fragments, Ba and Bb. Concentration of those fragments is about 2 logs lower than of factor B present in the blood, which makes fragment detection challenging because of potential cross-reactivity. Lack of information on Bb assay cross-reactivity stimulated the authors to investigate this issue. We ran 109 healthy donor EDTA plasmas and 80 sera samples with both factor B immunodiffusion (The Binding Site) and Quidel Bb EIA assays. During the study it was shown that physiological concentrations of gently purified factor B demonstrated approximately 0.15% cross-reactivity in the Quidel Bb EIA assay. We also observed that Bb concentration in serum is higher than in plasma due to complement activation during clot formation which let us use sera as samples representing complement activated state. Our study demonstrated that despite the potential 0.15% cross-reactivity between endogenous factor B and cleaved Bb molecule, measuring plasma concentrations of factor Bb is adequate to evaluate the activation of the alternative complement pathway.

Introduction ============ Lung cancer is one of the leading causes of cancer-associated morbidity and mortality in developed countries ([@b1-ol-0-0-11663],[@b2-ol-0-0-11663]). Non-small cell lung cancer (NSCLC), comprising mainly adenocarcinomas (ADCs) and squamous cell carcinomas (SCCs), is the most common histological type, accounting for \>80% of all lung carcinomas ([@b3-ol-0-0-11663]). Erlotinib is a tyrosine kinase inhibitor that inhibits epidermal growth factor receptor (EGFR) ([@b4-ol-0-0-11663]). Sensitizing mutations in the EGFR gene are a predictive factor for erlotinib use in first-line treatment ([@b5-ol-0-0-11663]). However, it has been hypothesized that erlotinib may be effective in further treatment lines in patients with wild type (wt) EGFR who lack proven mutations based on data from lung SCC where EGFR sensitizing mutations are rare ([@b6-ol-0-0-11663]). Due to the higher effectiveness of chemotherapy, erlotinib is primarily administered in third-line treatment for EGRF wt patients with lung carcinomas ([@b7-ol-0-0-11663]). Third-line erlotinib therapy has been demonstrated to be effective in a small percentage of patients with EGFR-wt NSCLC ([@b6-ol-0-0-11663]). Therefore, further research may be beneficial in identifying a predictive marker for the successful use of erlotinib ([@b6-ol-0-0-11663]). Immunohistochemical (IHC) parameters, such as thyroid transcription factor 1 (TTF1) or p63, may be candidate predictors ([@b8-ol-0-0-11663]). TTF1 is a nuclear protein transcription factor that is utilized as a marker for lung adenocarcinoma diagnosis ([@b9-ol-0-0-11663]). The prognostic role of TTF1 expression in patients with NSCLC has been previously assessed in several studies with conflicting results ([@b10-ol-0-0-11663]--[@b12-ol-0-0-11663]). Previous studies initially hypothesized TTF1 may serve a prognostic role in early NSCLC and later reported a possible role in advanced NSCLC, as confirmed by subsequent meta-analyses ([@b13-ol-0-0-11663],[@b14-ol-0-0-11663]). p63 is a gene located on chromosome 3q and is a member of the p53 family ([@b15-ol-0-0-11663]). p63 serves a major role in the cell cycle and squamous cell differentiation ([@b9-ol-0-0-11663]). Additionally, p63 has been described as a possible prognostic marker for NSCLC, despite conflicting results ([@b16-ol-0-0-11663],[@b17-ol-0-0-11663]). For example, Ma *et al* ([@b16-ol-0-0-11663]) demonstrated that high p63 expression was associated with better prognosis, while Pelosi *et al* ([@b17-ol-0-0-11663]) did not identify any prognostic influence of p63 in patients with NSCLC, despite p63 immunoreactivity being connected with tumor grading. The current retrospective study evaluated the association between TTF1 and p63 expression and outcome for patients with EGRF wt NSCLC treated with erlotinib in second- or third-line therapies. Materials and methods ===================== ### Data source TULUNG (tulung.registry.cz) is a non-interventional post-registration multi-center database that lists the epidemiological and clinical data of patients with advanced NSCLC treated with targeted or novel therapies in the Czech Republic. The registry contains anonymized individual patient data, including demographic parameters, initial staging and disease characteristics, baseline patient information at the beginning of targeted therapy and data on survival and adverse events. TTF1 and p63 expression data were extracted from the hospital information system of the University Hospital in Pilsen and merged with registry data. The TULUNG registry project, including further use of its data, was approved by the Local Ethics Committee of the University Hospital in Pilsen. All patients gave written informed consent to participate. ### Patients and treatment A total of 345 adult patients (\>18 years old) from the University Hospital in Pilsen with histologically confirmed locally advanced (IIIB) or metastatic (IV) stage EGRF wt NSCLC treated with erlotinib between January 2008 and December 2018 entered in the TULUNG registry (the database was screened for patients admitted at these dates). Erlotinib was administered orally at a standard approved dose (150 mg daily until disease progression or discontinuation due to side effects) as second- or third-line treatment as per routine clinical practice. Dose interruption (for maximum 1 month) or reduction (to 100 or 50 mg daily) was permitted in the event of treatment-related toxicity. The Eastern Cooperative Oncology Group performance status (ECOG PS) was determined according to established criteria (<https://ecog-acrin.org/resources/ecog-performance-status>). According to national guidelines, EGFR mutations are not commonly investigated in patients with SCC ([@b18-ol-0-0-11663]). A total of 9 patients had ADC in the unknown subcategory (due to lack of biopsy material for EGFR testing). ### Clinical monitoring Treatment was prospectively monitored and assessed at regular time intervals as per routine clinical practice. Clinical follow-ups, including physical examinations, plain chest X-rays and routine laboratory tests (hematology and basic biochemical tests) were performed every 3--4 weeks, until January 2019. Computed tomography or positron emission tomography was performed every 2--3 months. ### Assessment of TTF1 and p63 expression NSCLC diagnoses were established from lung tissue samples collected during bronchoscopy or computed tomography/ultrasound-guided biopsy at the University Hospital in Pilsen. Tissue were fixed for 24 h at room temperature using 10% neutral buffered formalin. All samples were cut into 4-µm-thick sections and embedded in paraffin. IHC staining, including antigen retrieval and blocking, was performed using a Ventana Benchmark XT automated stainer (Ventana Medical Systems, Inc.), according to the manufacturer\'s protocol. Slides were incubated with mouse monoclonal anti-TTF1 clone SPT24 primary antibody (1:400; cat. no. NCL-L-TTF-1; Novocastra Laboratories Ltd.) at 37°C for 32 min and mouse monoclonal anti-p63 clone 4A4 primary antibody (ready to use; cat. no. 790-4509; Ventana Medical Systems, Inc.) at 37°C for 24 min, followed by secondary antibody incubation using the ultraView Universal DAB detection kit (Ventana Medical Systems, Inc.) for 8 min at room temperature. Subsequently, slides were stained with hematoxylin for 8 min at room temperature, and observed under an Olympus BX 540 light microscope (Olympus Corporation; magnification, ×200). IHC staining was scored using a two-tiered scoring system: positive or negative. A positive score was based on moderate to strong nuclear staining obtained during routine IHC testing for NSCLC diagnosis by a trained pathologist. Staining was compared to a positive external control, such as thyroid gland tissue for TTF1 and skin for p63. The routine investigation was certified according to the Czech standards, European standards and International Organization for Standardization (biopticka.cz/cz/laborator/doc/Akreditace%20-%20Priloha.pdf) by an accredited laboratory (Biopticka laborator s.r.o.; <http://www.biopticka.cz/cz/laborator/doc/Akreditace.pdf>). TTF1 and p63 positive and negative staining is demonstrated in [Fig. 1](#f1-ol-0-0-11663){ref-type="fig"}. ### Statistical analysis The entire TULUNG cohort was analyzed to assess treatment results in all patients treated with erlotinib. Analysis was based on histology irrespective of TTF1/p63 expression. Additionally, a subgroup of patients with known TTF1/p63 expression was assessed (from the aforementioned hospital database). Standard descriptive statistics were used to characterize the sample dataset. Statistical analyses were performed using SPSS v25.0 (IBM Corp.) and R software version 3.5.1 (<https://www.R-project.org/>). Description of continuous characteristics of patients was presented as the mean ± SD, or as the median with minimum and maximum. If appropriate, continuous variables were categorized according to common cut-off points. Summary of categorical parameters was performed using absolute and relative frequencies. Relative frequencies were calculated as percentages from the number of patients in the relevant subgroup. Progression free survival (PFS) and overall survival (OS) were estimated using the Kaplan-Meier method and all point estimates were complemented with 95% confidence intervals (CIs). PFS was determined from the date of erlotinib treatment initiation and the date of the first documented progression (measured by Response Evaluation Criteria in Solid Tumors; version 1.1) ([@b19-ol-0-0-11663]) or death due to any cause. OS was determined from the date of erlotinib treatment initiation and the date of death due to any cause. Patients who had not progressed or died were censored at the date of the last follow-up. Statistical significance of the differences in Kaplan-Meier estimates were assessed using the log-rank test. Furthermore, a multivariate Cox proportional hazards model was utilized to evaluate the effect of all potential prognostic clinical/IHC factors on survival measures. P\<0.05 was considered to indicate a statistically significant difference. To assess the effect of the IHC factors, patients with NSCLC were split into three groups: A, patients with ADC who were TTF1 positive (TTF1+) and p63 negative (p63-); B, patients with SCC who were TTF1-/p63+; and C, patients who did not fall into any of the previous groups, including patients with ADC TTF1-/p63+ or SCC TTF1+/p63-. Results ======= ### Patient characteristics TULUNG contained data on 345 patients treated with erlotinib when the current study commenced. The baseline characteristics of a subgroup of 126 patients with known TTF1/p63 expression are summarized in [Table I](#tI-ol-0-0-11663){ref-type="table"}, while the remaining 219 patients were excluded due to unknown TTF1/p63 expression status. These patients were further divided into groups A, B and C as aforementioned, which included 40, 49 and 37 patients, respectively. Of these 126 patients, 2 had to reduce the dose (to 100 mg daily) and 3 had to discontinue treatment prematurely due to side effects (e.g. rash) of erlotinib. The demographic characteristics of patients in subgroups A, B and C are summarized in [Table II](#tII-ol-0-0-11663){ref-type="table"}. ### Survival of patients in the entire TULUNG group irrespective of TTF1/p63 expression No significant differences in PFS and OS were identified between patients with SCC and ADC, whether their condition was determined cytologically or histologically ([Table III](#tIII-ol-0-0-11663){ref-type="table"}). There were no statistically significant differences between PFS and OS for cytological vs. histological determination of samples in a total group of patients (ADC, OS P=0.098 and PFS P=0.808; SCC, OS P=0.166 and PFS P=0.269; data not shown). ### Survival of patients with known TTF1/p63 expression The current study revealed significant differences in PFS (P=0.006) and OS (P=0.002) between groups A, B and C. Median PFS was 2.6 (95% CI, 2.0; 3.1), 1.9 (95% CI, 1.6; 2.2) and 1.4 (95% CI, 0.5; 2.2) months in groups A, B and C, respectively. Median OS was 14.2 (95% CI, 9.6; 18.9), 19.1 (95% CI, 10.6; 27.6) and 5.3 (95% CI, 3.2; 7.5) months in groups A, B and C, respectively. Survival curves for PFS and OS are presented in [Figs. 2](#f2-ol-0-0-11663){ref-type="fig"} and [3](#f3-ol-0-0-11663){ref-type="fig"}, respectively. ### Multivariate analysis The multivariate Cox proportional hazards model ([Table IV](#tIV-ol-0-0-11663){ref-type="table"}) demonstrated significant associations between PFS and IHC parameters in groups A (P=0.03) and C (P=0.02). Similarly, a significant association was identified between OS and IHC parameters in groups A (P=0.003) and C (P=0.01). The only other significant association was between ECOG PS and OS (P=0.03; [Table IV](#tIV-ol-0-0-11663){ref-type="table"}). Discussion ========== The results of the current study suggested that TTF1 and p63 IHC markers may be useful predictors of erlotinib efficacy in patients with EGFR wt lung ADC/SCC. While the present study focused on IHC markers, previous studies have investigated the role of clinical parameters, such as gender, age and ECOG PS ([@b20-ol-0-0-11663]--[@b22-ol-0-0-11663]). The results of these studies have been inconsistent and no clinical parameter is currently routinely used as a predictive marker for erlotinib efficacy in patients with EGRF wt. Furthermore, certain parameters, including sex, smoking and histology may be associated with EGFR mutational status ([@b23-ol-0-0-11663]). In the current study, the majority of patients with unknown EGFR status had SCC (in which EGFR mutations are rare) and no effect of histology was reported. Previous studies have reported similar results ([@b7-ol-0-0-11663],[@b22-ol-0-0-11663],[@b24-ol-0-0-11663]). None of the clinical parameters were reported to be associated with outcome in the present cohort, except ECOG PS and OS. Therefore, the current study hypothesized that these clinical parameters alone should not be considered as suitable predictive indicators of erlotinib efficacy in patients with EGFR wt. Primary investigation into TTF1 and p63 IHC parameters during the current study aimed to determine their possible prognostic use. TTF1 was first described as a marker for distinguishing SCC from ADC ([@b25-ol-0-0-11663],[@b26-ol-0-0-11663]). Additionally, subsequent studies have reported its prognostic significance in other types of NSCLC ([@b27-ol-0-0-11663]--[@b29-ol-0-0-11663]). While association between TTF1 and prognosis was initially uncertain in advanced ADC, subsequent meta-analysis has verified its role ([@b14-ol-0-0-11663]). However, the present study did not take into account the possible effect of EGFR mutations that are more common in TTF1+ ADC ([@b30-ol-0-0-11663]). The prognostic role of TTF1 in patients with EGFR wt was demonstrated by Zhu *et al* ([@b28-ol-0-0-11663]) in patients who had undergone ADC and SCC tumor resections and exhibited mixed histology. However, there are inconsistent data on the effect of p63 on patient prognosis. Ma *et al* ([@b16-ol-0-0-11663]) demonstrated improved OS in patients with higher p63 expression in early stage NSCLC. However, Pelosi *et al* ([@b17-ol-0-0-11663]) did not observe any prognostic significance of p63 in a patient group with a mix of stages and histological types of NSCLC. The multivariate analysis of patients with advanced NSCLC in the current study demonstrated similar prognoses to patients with ADC TTF1+/p63- and SCC p63+/TTF1- and improved outcome of these two groups compared with tumors that did not exhibit IHC expression. Therefore, the present study hypothesized that IHC expression, disease stage, tumor histology and EGFR status should comprehensively be taken into account. Otherwise, biased results may be obtained as TTF1 expression appeared to be a prognostic factor only in ADC and p63 expression in SCC. Furthermore, different levels of significance of IHC expression cannot be excluded between patients who have advanced tumors, have undergone tumor resections or have ADCs with or without EGFR mutations. The current study demonstrated that patients who exhibited TTF1/p63 expression as expected for the given EGFR wt carcinoma subtype, responded significantly better to erlotinib treatment compared with patients with an atypical IHC profile. While the mechanism of action has not been fully elucidated, it may be associated with TTF1/p63 and EGFR, whose pathological activity is associated with lung cancer ([@b31-ol-0-0-11663]--[@b34-ol-0-0-11663]). TTF1 is known to directly exert its effects on EGFR, likely by mediating Leucine-rich immunoglobulin repeats-1 and β-catenin ([@b31-ol-0-0-11663],[@b32-ol-0-0-11663]). An association between p63 and EGFR has been demonstrated in breast cancer ([@b33-ol-0-0-11663],[@b34-ol-0-0-11663]). Furthermore, Nakahara *et al* ([@b8-ol-0-0-11663]) revealed longer time-to-treatment failure and OS in Asian patients with NSCLC EGRF wt who were treated with erlotinib. The current study contributed to the discussion on the predictive power of TTF1/p63 on higher line erlotinib treatment efficacy by providing novel data in two ways. Firstly, the TTF1-related results by Nahakara *et al* ([@b8-ol-0-0-11663]) were corroborated in a Caucasian population. Secondly, the present study reported data on the association between p63 expression and the outcome of erlotinib treatment. Overall, it is necessary to use TTF1 and p63 IHC markers concurrently as this allows differentiation of the prognostic groups described in the present study. Additionally, absence of IHC markers may lead to poor tumor classification ([@b35-ol-0-0-11663]). However, the current study did not observe statistically significant differences between cytological and histological samples. The primary limitations of the current study are the retrospective design and relatively small set of patients with known TTF1/p63 expressions from a single institution. Therefore, it would be useful to verify the current thesis in a larger multicenter prospective study. In conclusion, patients with EGRF wt lung carcinomas that do not exhibit TTF1 and p63 expression for ADC (TTF1+/p63-) or SCC (p63+/TTF1) were reported to have significantly lower PFS and OS, as well as poorer disease prognosis, and do not appear to be suitable candidates for erlotinib treatment. Not applicable. Funding ======= The current study was supported by Agentura pro zdravotnicky vyzkum (grant no. 17-307484) and by the National Sustainability Program I (grant no. LO1503) provided by the Ministry of Education, Youth and Sports of the Czech Republic and by the Charles University Research Fund (Progres Q39). Availability of data and materials ================================== The data sets used and/or analyzed during the present study are available from the corresponding author on reasonable request. Authors\' contributions ======================= MS, OF and PM wrote the manuscript. MS, GK, JB, OF, PM and MP analyzed and interpreted the patient general data. KH and MB were responsible for the analysis of the observation indicators. All authors read and approved the final manuscript. Ethics approval and consent to participate ========================================== The processing of data in the TULUNG registry has been approved by the Local Ethics Committee. Signed informed consent from the patients was obtained in the TULUNG registry. Patient consent for publication =============================== Not applicable. Competing interests =================== The authors declare that they have no competing interests. ###### Immunohistochemical expression in the nuclei of examined tumors. Lung adenocarcinoma with (A) TTF1 positivity and (B) p63 negativity. Lung squamous cell carcinoma with (C) TTF1 negativity and (D) p63 positivity. Magnification, ×200. TTF1, thyroid transcription factor 1.     {#f2-ol-0-0-11663} {#f3-ol-0-0-11663} ###### Baseline patient characteristics of 126 patients with ADC or SCC. Characteristics No. Percentage --------------------------------------------------------- ------------- ------------ Age, years   \<65 78 61.9   ≥65 48 38.1   Median (min-max) 62 (28--78) Sex   Male 77 61.1   Female 49 38.9 EGOG PS at treatment initiation   0   4   3.2   1 91 72.2   ≥2 31 24.6 Stage at treatment initiation   IIIB 38 30.2   IV 88 69.8 EGFR mutation   Negative 88 69.8   Unknown^[a](#tfn1-ol-0-0-11663){ref-type="table-fn"}^ 38 30.2 Smoking   Smokers 74 58.7   Ex-smokers 31 24.6   Non-smokers 21 16.7 Line of therapy   Second-line 63 50.0   Third line 63 50.0 Histology   ADC 68 54.0   SCC 58 46.0 According to national guidelines, EGFR mutations are not commonly investigated in patients with SCC. A total of 9 patients had ADC in the unknown subcategory. ADC, adenocarcinoma; SCC, squamous cell carcinoma; ECOG PS, Eastern Co-operative Oncology Group performance status; EGFR, epidermal growth factor receptor. ###### Demographic characteristic of patients in group A (n=40), B (n=49) and C (n=37). Characteristics Group A Group B Group C -------------------- ------------------- ------------------- ------------------- Sex, n (%)   Male 22 (55.0) 36 (73.5) 19 (51.4)   Female 18 (45.0) 13 (26.5) 18 (48.6) Age, n (%)   \<65 years 29 (72.5) 23 (46.9) 26 (70.3)   ≥65 years 11 (27.5) 26 (53.1) 11 (29.7)   Median (min-max) 60.5 (28.0--76.0) 65.0 (49.0--78.0) 60.0 (28.0--72.0) ###### PFS and OS for 345 patients with ADC or SCC verified either cytologically or histologically. Verification ADC SCC P-value ------------------------------- -------------------- ------------------- --------- Verified cytologically   No. of patients 112 101   Median PFS, months (95% CI) 1.9 (1.7; 22) 1.9 (1.8; 2.1) 0.70   Median OS, months (95% CI)   10.6 (7.1; 14.0)   8.2 (5.8; 10.5) 0.78 Verified histologically   No. of patients 70 62   Median PFS, months (95% CI) 1.9 (1.5; 2.3) 1.9 (1.2, 2.7) 0.15   Median OS, months (95% CI) 13.2 (7.7; 18.9) 19.5 (9.1; 29.6) 0.87 PFS, progression-free survival; OS, overall survival; ADC, adenocarcinoma; SCC, squamous cell carcinoma; CI, confidence interval. ###### Multivariate Cox analysis of 126 patients with ADC or SCC. PFS OS --------------- ------------------------ ------ ------------------------ ------- Age 0.982 (0.961; 1.003) 0.10 0.982 (0.953; 1.012) 0.24 Sex 0.934 (0.636; 1.370) 0.73 1.532 (0.916; 2.563) 0.10 Smoking 1.046 (0.629; 1.737) 0.86 1.037 (0.517; 2.080) 0.92 ECOG PS 1.411 (0.956; 2.080) 0.08 1.889 (1.083; 3.296) 0.03 Stage 1.192 (0.791; 1.797) 0.40 1.491 (0.815; 2.728) 0.20 EGFR status 0.849 (0.564; 1.278) 0.43 0.768 (0.417; 1.414) 0.40 IHC parameter   Group A 1 (reference category) 0.03 1 (reference category) 0.003   Group B 0.993 (0.629; 1.567) 0.98 0.813 (0.417; 1.584) 0.54   Group C 1.812 (1.109; 2.959) 0.02 2.367 (1.256; 4.462) 0.01 Age, \<65 years vs. ≥65 years; Smoking, ex-smoker vs. non-smoker; ECOG PS, 0/1 vs. ≥2; stage; IIIB vs. IV; EGFR status; EGFR negative vs. EGFR unknown. ADC, adenocarcinoma; SCC, squamous cell carcinoma; PFS, progression-free survival; OS, overall survival; ECOG PS, Eastern Cooperative Oncology Group performance status; EGFR, epidermal growth factor receptor; IHC, immunohistochemical; HR, hazard ratio; CI confidence interval.

Nowadays image processing techniques have come to be used in a variety of fields. For example, image processing is performed to address the degradation or modification of images acquired by a video recorder, a digital camera, or the like. In addition, image processing may be performed with a view to clearly understand the pattern of the structure and the structure itself to inspect whether the structure is built as designed. In medical institutions, a medical image diagnosis apparatus is used to obtain information on tissues in a subject. The medical image diagnosis apparatus creates from the information a medical image such as, for example, a perspective image, a tomographic image, and a blood flow image. The medical image is used for examination and diagnosis. Various types of image processing is performed to modify medical images in a variety of medical image diagnosis apparatuses such as, for example, X-ray computed tomography (CT) systems, magnetic resonance imaging (MRI) equipment, ultrasound diagnosis apparatuses, and X-ray diagnosis apparatuses. The utility of image processing to visualize a blood flow or a flow of a contrast agent, or to extract a lesion, contour of internal organs and the like is widely recognized. The image processing uses various types of elemental technologies such as noise removal or reduction, feature extraction, and pattern recognition. These technologies are used alone or in combination as appropriate. Among such elemental technologies, a technology to reduce random noise in an image is used to clearly reproduce an object photographed or reconstructed. However, conventional image processing, in particular noise reduction, requires further improvements. For example, smoothing is widely known as a noise reduction technology. Smoothing refers to processing in which, when an input value f(i, j) is provided for a pixel (i, j), the average density of neighboring pixels around the pixel (i, j) is used as an output value g(i, j) of the pixel (i, j). Specifically, assuming that n×n pixels in the vicinity of the pixel (i, j) are used as the neighboring pixels, the output value g(i, j) is obtained by the following formula (1): [ Formula ⁢ ⁢ 1 ] g ⁡ ( i , j ) = ∑ k = a b ⁢ ∑ m = c d ⁢ 1 ( b - a + 1 ) ⁢ ( d - c + 1 ) · f ⁡ ( i + k , j + m ) ( 1 ) where a, b, c, and d are integers, and 1/(b−a+1)(d−c+1) is a so-called weight. However, the simple use of this noise reduction may result in a so-called “edge blur”. The edge blur reduces the spatial resolution of an image, and the entire image is blurred. When the above noise reduction using formula (1) is applied to a medical image described above, for example, even if it is desired that a detailed blood vessel structure be rendered with as little noise as possible, pixels other than those of the blood vessel structure are also averaged (smoothed). That is, while reducing the noise, the smoothing also reduces the contrast that represents the blood vessel structure. As a result, it may be difficult to illustrate the detailed blood vessel structure. For this reason, there has been proposed an image processing apparatus that calculates the similarity between each pixel and neighboring pixels around the pixel in an image, and obtains a weighted average of them according to the similarity. The image processing apparatus uses the weighted average as a pixel value of the pixel. Thus, the image processing apparatus is capable of both suppressing image blur and reducing noise. Besides, as with a medical image acquisition device, the image processing apparatus may acquire information on the three-dimensional region of an object. Volume data is generated based on the information on the three-dimensional region thus acquired. The volume data is formed of a three-dimensional array of voxels (pixels). Each voxel is assigned with information (pixel value, etc.) indicating the density or the like of the object in the region. Further, in the image processing apparatus, noise reduction is performed on volume data as described above. For example, there is an image processing apparatus that performs noise reduction (two-dimensional noise reduction) with respect to any cross section of volume data to thereby achieve noise reduction of the entire volume data by isotropically diffusing the processing contents. At this time, the degree of the diffusion is determined depending on whether the region of interest includes edge information or not. For another example, there is an image processing apparatus that performs noise reduction by averaging or the like (three-dimensional noise reduction) for each voxel in the entire volume data. Further, in the image processing apparatus, noise reduction is performed between frames acquired in different time phases. For example, the noise reduction is performed by the use of corresponding pixels in the frames acquired in different time phases. In noise reduction for volume data, in the case of two-dimensional noise reduction, noise may not be sufficiently reduced. Besides, when a different cross section other than the one that is subjected to noise reduction (e.g., a cross section in a different cross-section direction) is observed, there is a case where the noise reduction is not appropriate. In other words, if the object is a human body, information that each voxel has in volume data is unlikely to be uniform. That is, there is likely to be a difference between a cross section subjected to the noise reduction and the different cross section in nature such as the tendency of the distribution of pixel values of pixels. As a result, even if noise reduction is performed on a predetermined cross section in volume data, for example, the noise reduction is not always applicable to a cross section perpendicular to the cross section. Accordingly, signal such as artifacts may appear in a critical area in an image. The same applies to the case where noise reduction is performed between frames acquired in different time phases. Further, there is a possibility that, when two-dimensional noise reduction is performed a plurality of times on the same cross section to achieve higher noise reduction effect, an edge portion of the image in the cross section is blurred. This is significant in the different cross sections. On the other hand, in the case of three-dimensional noise reduction, the amount of computation required for the processing is huge. This is, for example, the case that weighted average is performed according to the similarity between each voxel and those around it. As a result, the processing time may be increased by three-dimensional noise reduction.

Stereoselective β-F Elimination Enabled Redox-Neutral [4 + 1] Annulation via Rh(III)-Catalyzed C-H Activation: Access to Z-Monofluoroalkenyl Dihydrobenzo[ d]isoxazole Framework. An efficient and practical Rh(III)-catalyzed redox-neutral [4 + 1] annulation of N-phenoxy amides with α, α-difluoromethylene alkynes has been realized to give direct access to the Z-configured monofluoroalkenyl dihydrobenzo[ d]isoxazole framework with broad substrate compatibility and good functional group tolerance, which was further enhanced by the late-stage C-H modification of complex bioactive compounds. Subsequent density functional theory calculations revealed that the stereoselective β-F elimination involving an allene species played a decisive role in determining the reaction outcome and such Z-selectivity.

J. D. Stenger-Smith, L. Baldwin, A. Chafin, P. A. Goodman, *ChemistryOpen* **2016**, *5*, 269. In one word, how would you describe your research? {#open201600076-sec-0001} ==================================================  *Diverse*. Many topics are of interest to the Navy, and at their core each of them has fundamental aspects that need to be explored and understood. Our focus is on trying to identify the fundamental questions behind the Navy\'s needs and then try to answer them. What is the most significant result of this study? {#open201600076-sec-0002} ================================================== The true significance of this study is that by using (tetrahydrofuran‐2‐yl)methyl methanesulfonate in the synthesis of *bis*(tetrahydrofurfuryl) ether, we demonstrated that this intermediate allows one to synthesize pure tetrahydrofurfuryl ethers with bulkier substituents in a relatively straightforward manner. *Bis*(tetrahydrofurfuryl) ether, in particular, is interesting because its structure suggests that it may act as a chelating agent for cations, which could be useful in organic synthesis or energy‐storage applications. What was the biggest challenge (on the way to the results presented in this paper)? {#open201600076-sec-0003} =================================================================================== Our biggest challenge was finding out why our initial elemental analyses were slightly out of the calculated range. We sent multiple samples to multiple companies and, while the elemental analyses were close to the predicted values, they didn\'t quite fit with our NMR and GC/MS analyses---all indicating at least 99.5% purity. It turns out that the samples picked up a little moisture during the trip to the elemental analysis facility. Once we figured this out and requested that the samples be dried, the elemental analyses matched the predicted values. What was the biggest surprise (on the way to the results presented in this paper)? {#open201600076-sec-0004} ================================================================================== The biggest surprise that we faced, as noted in the text, is that the intermediate, (tetrahydrofuran‐2‐yl)methyl methanesulfonate, reacts violently with air, but only when it is at an elevated temperature. At room temperature, it appears to be relatively stable, or at least the reaction is much slower. *We gratefully acknowledge the NAWCWD Internal Investment Program, Power Systems Initiative for the funding that supported this effort*. 

Experimental study of meropenem in the therapy of cephalosporin-susceptible and -resistant pneumococcal meningitis. Meropenem is a carbapenem antibiotic that is highly active against the pathogens causing meningitis. Results with meropenem in the experimental rabbit model of penumococcal meningitis have been controversial, and the possible role of renal dehydropeptidase I in meropenem efficacy has been suggested. The aim of this study was to determine the efficacy of meropenem in two meningitis models and the possible influence of the animal model over results. Two strains of Streptococcus pneumoniae with different susceptibility to beta-lactams have been used in a guinea pig model and the classical rabbit meningitis model. Meropenem was bactericidal at 6 h in the guinea pig model against both strains with a reduction of >4 log ufc/ml. In the rabbit model it was bactericidal at 6 h against the susceptible strain, but against the resistant 3/8 therapeutical failures were recorded at 6 h, being bactericidal at 24 h. In conclusion, meropenem has shown bactericidal activity in both experimental models. This work emphasises the importance of an adequate election of the animal model for the appropriate development of studies of antimicrobial efficacy. We believe that guinea pig should be considered the best choice among laboratory animal species when assessing meropenem efficacy.

--- name: 'rsync' runner_type: 'remote-shell-cmd' description: 'Copy file(s) from one place to another w/ rsync' enabled: true entry_point: '' parameters: source: type: 'string' description: 'List of files/directories to to be copied' required: true dest_server: type: 'string' description: "Destination server for rsync'd files" required: true destination: type: 'string' description: 'Destination of files/directories on target server' required: true cmd: immutable: true default: 'rsync {{args}} {{source}} {{dest_server}}:{{destination}}' connect_timeout: type: 'integer' description: 'SSH connect timeout in seconds' default: 30 args: description: 'Command line arguments passed to rysnc' default: '-avz -e "ssh -o ConnectTimeout={{connect_timeout}}"'

A city located on the eastern coast of Scotland, where the river Ness flows from Loch Ness into the North Sea, Inverness was the city over which the Banchory Bangers Quidditch team was apprehended by Ministry of Magic officials as they tried to fly off and capture a Hebridean Black dragon for their team mascot (QA5). Inverness is not far from the location where Hogwarts is generally assumed to be.

Q: USB Flash drives and data theft: x355 Can somebody have stolen files and data from my desktop PC just by inserting a USB Flash drive in my computer, without dragging files over to the Flash drive? A: Yes, easily. Removable devices (such as USB, or CD-ROM disks) have "AutoPlay" support on Windows. This is designed to auto-run installation CD-ROMs; just insert the CD and the installer starts. It works like this: if in the root of the newly inserted device an "AUTORUN.INF" file is found, then its instructions are executed; they may tell the system to display a special, cooler icon for the device, but also to execute a program from the device. Both the autorun file and the program may be hidden so that you don't see them on the device, and it appears empty. This executable could then do anything the logged-in user can do: it could run a search on the hard disk, and copy matching files on a hidden folder in the USB key. Or install a virus (that's how USB viruses such as Conficker propagate) that could then trasmit files at leisure through the Internet, if the computer was online. It is easy to write such an autorun INF file using Notepad, and the executable can be built with any of several tools such as AutoIt, or it could even be a .CMD or .BAT file, which too can be created with just Notepad. There are even "ready made" tools out there, such as, if memory serves, Slurper: install the program insert the USB key choose the file search parameters (e.g. "Files newer than one week") click "OK" and the utility saves on the USB key an autorun file and executable that... ... ...when you insert the USB key in a computer, will search matching files and "slurp" them on the USB key, optionally even deleting them. UPDATE: There also happens to be a howto on Superuser. Workarounds: on Windows XP, keep the "SHIFT" key pressed while inserting the flash drive. This disables autorun execution. Also works on Seven, haven't tried on Windows 8. And of course, you can disable the autoplay functionality (also here), which is always a good idea. You never know where those USB keys have been, after all. (IPQ sells a write-protectable USB key that allows you to let someone copy a file on his untrusted-by-you computer, without said computer being able to infect the USB key with malware. Other WP keys are available e.g. on Amazon).

Q: Python beginner confused by a complex line of code I understand the gist of the code, that it forms permutations; however, I was wondering if someone could explain exactly what is going on in the return statement. def perm(l): sz = len(l) print (l) if sz <= 1: print ('sz <= 1') return [l] return [p[:i]+[l[0]]+p[i:] for i in range(sz) for p in perm(l[1:])] A: This return is returning a list comprehension whose items are made by inserting the first item of l into each position of p, from the first to the last -- p in turn is a list of lists, obtained by a recursive call to perm which excludes the first item of l (and thus permutes all other items in all possible ways). If you don't understand recursion, it's not really trivial to explain;-). If you don't understand list comprehensions, they are trivial to explain -- that return is semantically equivalent to result = [] for i in range(sz): for p in perm(l[1:]): result.append(p[:i]+[l[0]]+p[i:]) return result this also shows how inefficient this code is: it's calling perm recursively sz times, and obviously there's no need for it. Much better would be to simply swap the two for loops: result = [] for p in perm(l[1:]): for i in range(sz): result.append(p[:i]+[l[0]]+p[i:]) return result and the equivalent of this, much better code, is a list comprehension with the two for clauses swapped: return [p[:i]+[l[0]]+p[i:] for p in perm(l[1:]) for i in range(sz)] A: The return statement is using a list comprehension. It's a bit easier to understand if you put it into actual loops: value = [] for i in range(sz): # call this function using all but the first item in l for p in perm(l[1:]): # now place the first item in l between index i-1 and index i in p value.append(p[:i] + [l[0]] + p[i:]) return value

/* the norm */ #gritter-notice-wrapper { position:fixed; top:20px; right:20px; width:301px; z-index:9999; } #gritter-notice-wrapper.top-left { left: 20px; right: auto; } #gritter-notice-wrapper.bottom-right { top: auto; left: auto; bottom: 20px; right: 20px; } #gritter-notice-wrapper.bottom-left { top: auto; right: auto; bottom: 20px; left: 20px; } .gritter-item-wrapper { position:relative; margin:0 0 10px 0; background:url('../images/ie-spacer.gif'); /* ie7/8 fix */ } .gritter-top { background:url("..images/gritter.png") no-repeat left -30px; height:10px; } .hover .gritter-top { background-position:right -30px; } .gritter-bottom { background:url("../images/gritter.png") no-repeat left bottom; height:8px; margin:0; } .hover .gritter-bottom { background-position: bottom right; } .gritter-item { display:block; background:url("../images/gritter.png") no-repeat left -40px; color:#eee; padding:2px 11px 8px 11px; font-size: 11px; font-family:verdana; } .hover .gritter-item { background-position:right -40px; } .gritter-item p { padding:0; margin:0; word-wrap:break-word; } .gritter-close { display:none; position:absolute; top:5px; left:3px; background:url("../images/gritter.png") no-repeat left top; cursor:pointer; width:30px; height:30px; } .gritter-title { font-size:14px; font-weight:bold; padding:0 0 7px 0; display:block; text-shadow:1px 1px 0 #000; /* Not supported by IE :( */ } .gritter-image { width:48px; height:48px; float:left; } .gritter-with-image, .gritter-without-image { padding:0; } .gritter-with-image { width:220px; float:right; } /* for the light (white) version of the gritter notice */ .gritter-light .gritter-item, .gritter-light .gritter-bottom, .gritter-light .gritter-top, .gritter-light .gritter-close { background-image: url("../images/gritter-light.png"); color: #222; } .gritter-light .gritter-title { text-shadow: none; }

Dissertation/Thesis Abstract Mint Green is a limited liability company who provides preventative health care services to the Greater Long Beach area. Mint Green is entering the Weight Loss Services Industry which is experiencing rapid growth due to the enactment of the Patient Protection and Affordable Care Act. Mint Green has the opportunity to reach approximately 65% of firms who offer health benefits to their employees. Mint Green’s Healthy Eating and Lifestyle Plan (HELP) is the core instruction to the weight loss programs. Mint Green has four types of weight loss programs; each developed to satisfy a wide array of budgets. Mint Green is projected to yield a profitable margin. Terms of Use The supplemental file or files you are about to download were provided to ProQuest by the author as part of a dissertation or thesis. The supplemental files are provided "AS IS" without warranty. ProQuest is not responsible for the content, format or impact on the supplemental file(s) on our system. in some cases, the file type may be unknown or may be a .exe file. We recommend caution as you open such files. Copyright of the original materials contained in the supplemental file is retained by the author and your access to the supplemental files is subject to the ProQuest Terms and Conditions of use. Depending on the size of the file(s) you are downloading, the system may take some time to download them. Please be patient.

Sensitive and selective LC-MS/MS assay for quantitation of flutrimazole in human plasma. A highly sensitive liquid chromatography-tandem mass spectrometry method was developed and validated for the determination of flutrimazole in human plasma. This study was to investigate the application of sensitive and selective LC-MS/MS method for quantitation of flutrimazole in human plasma. The analysis and internal standard were extracted with ether and hexane (v:v, 1:1) followed by a rapid isocratic elution with a 0.1% formic acid/methanol (v:v, 20:80) on a C18 column (50 mm × 2.1 mm I.D.) and subsequent analysis by mass spectrometry in the multi-reaction-monitoring mode. The precursor to production transitions of m/z 279.0 → 183.1 and m/z 441.0 → 295.1 were used to measure the analyte and the internal standard. The assay was linear over the concentration range of 0.996-99.6 ng•mL-1 for flutrimazole in human plasma. The lower limit of quantification was 0.996 ng•mL-1 and the extraction recovery was larger than 78.83% for flutrimazole. The inter- and intra-day precision of the method at three concentrations was less than 9.26%. The LC-MS/MS method was firstly applied to quantitation of flutrimazole in human plasma.

An ERCC4 regulatory variant predicts grade-3 or -4 toxicities in patients with advanced non-small cell lung cancer treated by platinum-based therapy. Platinum-based chemotherapy (PBC) in combination with the 3rd generation drugs is the first-line treatment for patients with advanced non-small cell lung cancer (NSCLC); however, the efficacy is severely hampered by grade 3-4 toxicities. Nucleotide excision repair (NER) pathway is the main mechanism of removing platinum-induced DNA adducts that contribute to the toxicity and outcome of PBC. We analyzed data from 710 Chinese NSCLC patients treated with PBC and assessed the associations of 25 potentially functional single nucleotide polymorphisms (SNPs) in nine NER core genes with overall, gastrointestinal and hematologic toxicities. Through a two-phase study, we found that ERCC4 rs1799798 was significantly associated with overall and gastrointestinal toxicities [all patients: GA/AA vs. GG, odds ratio (OR)adj =1.61 and 2.35, 95% confidence interval (CI)=1.11-2.33 and 1.25-4.41, and Padj =0.012 and 0.008, respectively]. Our prediction model for the overall toxicity incorporating rs1799798 demonstrated a significant increase in the area under the curve (AUC) value, compared to that for clinical factors only (all patients: AUC = 0.61 vs. 0.59, 95% CI = 0.57-0.65 vs. 0.55-0.63, P = 0.010). Furthermore, the ERCC4 rs1799798 A allele was associated with lower ERCC4 mRNA expression levels according to the expression quantitative trait loci (eQTL) analysis. Our study provided some new clue in future development of biomarkers for assessing toxicity and outcomes of platinum drugs in lung cancer treatment.

Radiant energy heating systems are commonly used in industrial and commercial buildings. Radiant heater systems are more efficient and cost-effective than forced air systems because the emitted infrared rays heat objects and concrete floors rather than large volumes of air. The concrete floors absorb the radiant energy and re-radiate it back into the surrounding air to maintain a blanket of warmth within the heated space. By thus heating from the bottom up, the stratification of heat within the building that tends to occur with a forced air system is minimized, with consequent improvements in comfort and fuel efficiency. Some radiant space heating systems are supplied in component form, the radiator tube of the installed system being built up from various straight and curved sections as needed to route the radiator tube through the area of the building where heating is desired. In such a system, a burner unit is located at a first end of the tube and an exhaust fan is typically located at the opposite end of the tube to draw the hot effluent through the tube. Alternatively, a radiant heater may be manufactured and delivered as an assembled unit comprising an elongated, U-shaped radiator tube, a burner unit, and an exhaust fan. A reflector is disposed above the radiator tube to direct the radiant energy in the desired direction. The unit is provided with hangers which permit it to be suspended from a ceiling or other overhead structure. Such radiant heater units intended for industrial or commercial use and rated at 20k BTU/hour to 50k BTU/hour are typically over 10 feet in overall length. Scaled down versions of the above-described radiant heater units have been produced and marketed for use in residential heating applications. Such residential units have been six feet or more in overall length, and therefore can not be mounted within the standard two foot by four foot openings in suspended ceiling systems. If a conventional U-tube radiant heater is scaled down to have an overall length of less than six feet, the total length of the radiator tube is reduced to the point where the exhaust effluent still contains significant useful thermal energy. This leads to a reduction in the efficiency of the heater, and requires that the exhaust ducting be able to withstand higher temperatures. Another reason why it has not previously been practical to produce a radiant heater in the 20k-40k BTU/hr range having an overall length of four feet or less is that burners as heretofore used to produce heat outputs in that range generate a flame which is well over four feet long. Even using a U-shaped radiator tube, the tube can not have a straight segment more than four feet long, so that the flame must impinge on the inner surface of the radiator tube in the vicinity of the 180.degree. bend. Impingement on the flame on the tube causes quenching of the flame, with a consequent increase in undesirable emissions such as carbon monoxide. The flame also crates a hot-spot on the radiator tube, which results in premature oxidation of the tube material and eventual burn-through. It is possible to decrease the length of the flame produced by the burner by increasing the amount of air flow through the burner venturi. Conventional methods for achieving this increase in what is known as the primary air flow involve either a) enlarging the diameter of the venturi or b) increasing the pressure of the air drawn or forced through the venturi. Both of these options have effects that are undesirable in a heater unit for residential use. Increasing the venturi diameter is undesirable because it forces an increase in the diameter of the radiator tube in order to maintain adequate clearance between the exterior of the venturi and the interior of the surrounding radiator tube. Sufficient clearance must be maintained to permit the flow of air around the outside of the venturi, the flow of this so-called secondary air being critical in cooling the radiator tube containing the flame. An increase in radiator tube diameter increases the depth of the unit, and also forces an increase in the radius of the bend connecting the straight segments of the tube so that they must lie farther apart, thus making the unit wider. The other possibility, increasing the air velocity through the burner, leads to an increase in the level of noise made by combustion, the fast-burning flame making a "roaring" sound. In a residential application it is particularly important that the heater operate quietly. Another drawback inherent in prior radiant heaters is that electromechanical components of the heater, such as the fan, gas supply valve and electronic control unit, are difficult to service and inspect when the heater is installed in an overhead position. Servicing and/or inspection of these components involves either working on the heater in its installed position, or removing the entire heater from its installed position and moving it to a location where the components are more easily accessed. Some gas-fired radiant heaters include what is known in the art as an air flow switch, a mechanism for determining the amount of air being provided to the burner and shutting off the flow of gas if the air flow is not sufficient for proper functioning of the heater. Air flow may be reduced by any number of problems, for example a malfunctioning or blocked fan, or a blockage anywhere along the radiator tube or its exhaust ducting. In a heater having a pressurized plenum chamber supplying air to the burner, the air flow monitoring function is generally accomplished by a pair of pressure actuated switches located within the plenum chamber and wired to a control unit which cuts off the flow of gas through the valve if the pressure switches indicate that the pressure within the chamber is not within the acceptable range. One switch is actuated and sends a flow termination signal to the control unit if the pressure in the plenum chamber drops below a predetermined minimum, such as would occur if the fan were to slow or stop. The other switch sends a flow termination signal if the pressure rises above a predetermined maximum, such as would occur if the radiator tube or exhaust were blocked at any point downstream. The cost and complexity of the heater could be reduced if the air flow switch function could be accomplished with only one pressure switch requiring a single electrical connection to the control unit.

A recently developed Land Grid Array device or package (hereinafter referred to as an LGA device) comprises a rectangular ceramic plate carrying an integrated circuit of high complexity and having arrays of densely packed individual contact pads or lands located adjacent outer edges of a lower face thereof. Such device is susceptible of extreme miniaturization being, for example, 1.2 square inches in area and one tenth of an inch in thickness, while the individual pad or land size may be twenty five thousandths of an inch square (0.025.times.0.025 inches). Three rows of such individual pads may be located within one fifth of an inch of respective edges of the lower face. Clearly, therefore, great accuracy is required in aligning respective lands with respective contact pads of a circuit board. In view of the extreme miniaturization required for electronic devices, particularly hand carried devices, severe restrictions are imposed both on across-board and above-board space. There is therefore a requirement for a low profile socket connector for an LGA device that not only occupies very little above-board space but provides the requisite security and accuracy of mounting, at the same time satisfying the requirements of ease of assembly to the circuit board and economic production in high volume by conventional mass production techniques. U.S. Pat. No. 4,498,721 discloses an electrical connector for a planar electronic device or package comprising a generally rectangular base member providing a device-receiving socket and pressure interface connectors formed as elastomer connectors received in respective apertures in the base member, means for securing the base member on a circuit board, and a spring lid engageable with the securing means for mounting on the base member by engagement with the securing means while pressing the device against the elastomer connector to effect electrical connection between the device, the elastomer connector and the circuit board. However, disadvantages of the prior connector include the absence of any means positively locating the device in a lateral reference position, in coordinates in its plane. Accurate lateral positioning would, therefore, apparently depend on the closeness or preciseness of the fit of the device in the socket of the base member, which approach imposes severe limitations on the accommodation of even the small variations in dimension which would occur, even in the event of industry standardization, as a result of manufacturing tolerances. In consequence, undesirable limitations are imposed on contact size and density and, absent effective standardization, industry wide compatibility. Further disadvantages associated with the prior connector follow from the securing means relying on four threaded bolts which are time consuming to apply, with risk of over-tightening, a requirement for considerable above-board space to provide clearance for access during assembly and disassembly; protrusion of the bolt heads above the base member, increasing the intrinsic above-board height; and, the absence of means for reliably retaining the four, separate, elastomer pieces preassembled with the base member, prior to mounting on the circuit board, which increases assembly time.

Nelis Del Carmen Nelis, 57, is a widow and the mother of two daughters. She's a merchant who has a small store in her house. She installed this business to earn income to help support her family's expenses. This allowed her to develop as a merchant, to meet more customers, and to understand their needs. Previously she sold a variety of merchandise in the market with her husband, but when he died she had to learn how to survive on her own. She needs the loan to buy basic grains, soda, and dairy products. This will allow her to keep products in the shop that her customers want and need, and that also allow her to increase her income. One of her plans for the future is to open a small clothing and variety store.

package com.replaymod.extras.advancedscreenshots; import com.replaymod.core.versions.MCVer; import com.replaymod.render.RenderSettings; import com.replaymod.render.blend.BlendState; import com.replaymod.render.capturer.RenderInfo; import com.replaymod.render.rendering.Pipelines; import de.johni0702.minecraft.gui.utils.lwjgl.Dimension; import de.johni0702.minecraft.gui.utils.lwjgl.ReadableDimension; import net.minecraft.client.MinecraftClient; import net.minecraft.util.crash.CrashReport; //#if MC>=11400 import com.replaymod.render.mixin.MainWindowAccessor; import static com.replaymod.core.versions.MCVer.getWindow; //#endif //#if MC>=10800 import com.replaymod.render.hooks.ChunkLoadingRenderGlobal; //#endif import static com.replaymod.core.versions.MCVer.getRenderPartialTicks; public class ScreenshotRenderer implements RenderInfo { private final MinecraftClient mc = MCVer.getMinecraft(); private final RenderSettings settings; private int framesDone; public ScreenshotRenderer(RenderSettings settings) { this.settings = settings; } public boolean renderScreenshot() throws Throwable { try { //#if MC>=11400 int displayWidthBefore = getWindow(mc).getFramebufferWidth(); int displayHeightBefore = getWindow(mc).getFramebufferHeight(); //#else //$$ int displayWidthBefore = mc.displayWidth; //$$ int displayHeightBefore = mc.displayHeight; //#endif boolean hideGUIBefore = mc.options.hudHidden; mc.options.hudHidden = true; //#if MC>=10800 ChunkLoadingRenderGlobal clrg = new ChunkLoadingRenderGlobal(mc.worldRenderer); //#endif if (settings.getRenderMethod() == RenderSettings.RenderMethod.BLEND) { BlendState.setState(new BlendState(settings.getOutputFile())); Pipelines.newBlendPipeline(this).run(); } else { Pipelines.newPipeline(settings.getRenderMethod(), this, new ScreenshotWriter(settings.getOutputFile())).run(); } //#if MC>=10800 clrg.uninstall(); //#endif mc.options.hudHidden = hideGUIBefore; //#if MC>=11400 //noinspection ConstantConditions MainWindowAccessor acc = (MainWindowAccessor) (Object) getWindow(mc); acc.setFramebufferWidth(displayWidthBefore); acc.setFramebufferHeight(displayHeightBefore); mc.getFramebuffer().resize(displayWidthBefore, displayHeightBefore //#if MC>=11400 , false //#endif ); //#if MC>=11500 mc.gameRenderer.onResized(displayWidthBefore, displayHeightBefore); //#endif //#else //$$ mc.resize(displayWidthBefore, displayHeightBefore); //#endif return true; } catch (OutOfMemoryError e) { e.printStackTrace(); CrashReport report = CrashReport.create(e, "Creating Equirectangular Screenshot"); MCVer.getMinecraft().setCrashReport(report); } return false; } @Override public ReadableDimension getFrameSize() { return new Dimension(settings.getVideoWidth(), settings.getVideoHeight()); } @Override public int getFramesDone() { return framesDone; } @Override public int getTotalFrames() { // render 2 frames, because only the second contains all frames fully loaded return 2; } @Override public float updateForNextFrame() { framesDone++; return getRenderPartialTicks(); } @Override public RenderSettings getRenderSettings() { return settings; } }

--- abstract: 'We derive explicit forms of Markovian transition probability densities for the velocity space and phase-space Brownian motion of a charged particle in a constant magnetic field.' author: - | Rados[ł]{}aw Czopnik\ Institute of Theoretical Physics, University of Wroc[ł]{}aw,\ PL-50 205 Wroc[ł]{}aw, Poland\ and\ Piotr Garbaczewski\ Institute of Physics, Pedagogical University,\ PL-65 069 Zielona Góra, Poland title: Charged Brownian particle in a magnetic field --- Motivation ========== An old-fashioned problem of the Brownian motion of a charged particle in a constant magnetic field has originated from studies of the diffusion of plasma across a magnetic field [@Tay], [@Kur] and nowadays, together with a free Brownian motion example, stands for a textbook illustration of how transport and auto-correlation functions should be computed in generic situations governed by the Langevin equation cf. [@Bal] but also [@Sch], [@vKa]. To our knowledge, except for the paper [@Kur] no attempt was made in the literature to give a complete characterization of the pertinent stochastic process. However a striking peculiarity of Ref. [@Kur] is that the Brownian motion in a magnetic field is there described in terms of *operator-valued (matrix-valued functions) probability distributions that involve fractional powers of matrices. In consequence, we have no clean relationship with the standard formalism of Kramers-Smoluchowski equations, nor ways to stay in conformity with the standard wisdom about probabilistic procedures valid in case of the free Brownian motion (Ornstein-Uhlenbeck process), cf. [@Step], [@Cha], [@Nel]. Therefore, we address an issue of the Brownian motion of a charged particle in a magnetic field anew, to unravel its features of a fully-fledged stochastic diffusion process.* Velocity-space diffusion process ================================ The standard analysis of the Brownian motion of a free particle employs the Langevin equation $\frac{d\overrightarrow{u}}{dt}=-\beta \overrightarrow{u}+ \overrightarrow{A}% \left( t\right)$ where $\overrightarrow{u}$ denotes the velocity of the particle and the influence of the surrounding medium on the motion (random acceleration) of the particle is modeled by means of two independent contributions. A systematic part $-\beta \overrightarrow{u}$ represents a dynamical friction. The remaining fluctuating part $\overrightarrow{A}\left( t\right) $ is supposed to display a statistics of the familiar white noise: (i)$\overrightarrow{A}\left( t\right) $ is independent of $% \overrightarrow{u}$, (ii) $\left\langle A_{i}\left( s\right) \right\rangle = 0$ and $\left\langle A_{i}\left( s\right) A_{j}\left( s^{\shortmid }\right) \right\rangle =2q\delta _{ij}\delta \left( s-s^{\shortmid }\right) $ for $i,j=1,2,3$, where $q=\frac{k_{B}T}{m}\beta $ is a physical parameter. The Ornstein-Uhlenbeck stochastic process comes out on that conceptual basis. The linear friction model can be adopted to the case of diffusion of charged particles in the presence of a constant magnetic field which acts upon particles via the Lorentz force. The Langevin equation for that motion reads: $$\frac{d\overrightarrow{u}}{dt}=-\beta \overrightarrow{u}+\frac{q_{e}}{mc}% \overrightarrow{u}\times \overrightarrow{B}+\overrightarrow{A}\left( t\right) \label{Langevin}$$ where $q_{e}$ denotes an electric charge of the particle of mass $m$. Let us assume for simplicity that the constant magnetic field $\overrightarrow{B}$ is directed along the z-axis of a Cartesian reference frame: $ \overrightarrow{B}=\left( 0,0,B\right) $ and $B=const$. In this case Eq. (\[Langevin\]) takes the form $$\frac{d\overrightarrow{u}}{dt}=-\Lambda \overrightarrow{u}+ \overrightarrow{A}% \left( t\right) \label{LanII}$$ where $$\Lambda =\left( \begin{array}{ccc} \beta & -\omega _{c} & 0 \\ \omega _{c} & \beta & 0 \\ 0 & 0 & \beta \end{array} \right)$$ and $\omega _{c}=\frac{q_{e}B}{mc}$ denotes the Larmor frequency. Assuming the Langevin equation to be (at least formally) solvable, we can infer a probability density $P\left( \overrightarrow{u},t|% \overrightarrow{u}_{0}\right) $, $t>0$ conditioned by the the initial velocity data choice $\overrightarrow{% u}=\overrightarrow{u}_{0}$ at $t=0$. Physical circumstances of the problem enforce a demand: (i) $P\left( \overrightarrow{u},t|\overrightarrow{u}_{0}\right) \rightarrow \delta ^{3}\left( \overrightarrow{u}-\overrightarrow{u}% _{0}\right) $ as $t\rightarrow 0$ and (ii) $P\left( \overrightarrow{u},t|\overrightarrow{u}_{0}\right) \rightarrow \left( \frac{m}{2\pi k_{B}T}\right) ^{\frac{3}{2}}\exp \left( -\frac{m |\overrightarrow{u}_{0}| ^{2}}{2k_{B}T} \right) $ as $t\rightarrow \infty $. A formal solution of Eq. (\[LanII\]) reads: $$\overrightarrow{u}\left( t\right) -e^{-\Lambda t}\overrightarrow{u}% _{0}=\int_{0}^{t}e^{-\Lambda \left( t-s\right) } \overrightarrow{A}\left( s\right) ds \enspace . \label{sol1}$$ By taking into account that $$e^{-\Lambda t}=e^{-\beta t}\left( \begin{array}{ccc} \cos \omega _{c}t & \sin \omega _{c}t & 0 \\ -\sin \omega _{c}t & \cos \omega _{c}t & 0 \\ 0 & 0 & 1 \end{array} \right) =e^{-\beta t}U\left( t\right)$$ we can rewrite (\[sol1\]) as follows $$\overrightarrow{u}\left( t\right) -e^{-\beta t}U\left( t\right) \overrightarrow{u}_{0}=\int_{0}^{t}e^{-\beta \left( t-s\right) }U\left( t-s\right) \overrightarrow{A}\left( s\right) ds \enspace .$$ Statistical properties of $\overrightarrow{u}\left( t\right) -e^{-\Lambda t}\overrightarrow{u}_{0}$ are identical with those of $% \int_{0}^{t}e^{-\Lambda \left( t-s\right) } \overrightarrow{A}\left( s\right) ds$. In consequence, the problem of deducing a probability density $P\left( \overrightarrow{u},t|\overrightarrow{u}_{0}\right) $ is equivalent to deriving the probability distribution of the random vector $$\overrightarrow{S}=\int_{0}^{t}\psi \left( s\right) \overrightarrow{A}\left( s\right) ds \label{Sdef}$$ where $\psi \left( s\right) =e^{-\Lambda \left( t-s\right) }=e^{-\beta \left( t-s\right) }U\left( t-s\right)$. The white noise term $ \overrightarrow{A}\left( s\right) $ in view of the integration with respect to time is amenable to a more rigorous analysis that invokes the Wiener process increments and their statistics, [@Doob]. Let us divide the time integration interval into a large number of small subintervals $\Delta t$. We adjust them suitably to assure that effectively $\psi \left( s\right) $ is constant on each subinterval $\left( j\Delta t,\left( j+1\right) \Delta t\right) $ and equal $\psi \left( j\Delta t\right) $. As a result we obtain the expression $$\overrightarrow{S}=\sum_{j=0}^{N-1}\psi \left( j\Delta t\right) \int_{j\Delta t}^{\left( j+1\right) \Delta t}\overrightarrow{A}\left( s\right) ds \enspace . \label{S}$$ Here $ \overrightarrow{B}\left( \Delta t\right) =\int_{j\Delta t}^{\left( j+1\right) \Delta t}\overrightarrow{A}\left( s\right) ds$ stands for the above-mentioned Wiener process increment. Physically, $\overrightarrow{B}\left( \Delta t\right) $ represents the *net acceleration which a Brownian particle may suffer (in fact accumulates) during an interval of time $\Delta t$. Equation (\[S\]) becomes* $$\overrightarrow{S}=\sum_{j=0}^{N-1}\psi \left( j\Delta t\right) \overrightarrow{B}\left( \Delta t\right) = \sum_{j=0}^{N-1}\overrightarrow{s}% _{j}$$ where we introduce $\overrightarrow{s}_{j}=\psi \left( j\Delta t\right) \overrightarrow{B}\left( \Delta t\right) = \psi _{j}\overrightarrow{B}\left( \Delta t\right) $. The Wiener process argument [@Cha], [@Nel], allows us to infer the probability distribution of $\overrightarrow{s}_{j}$. It is enough to employ the fact that the distribution of $\overrightarrow{B}\left( \Delta t\right) $ is Gaussian with mean zero and variance $q=\frac{k_{B}T}{m}\beta $. Then $$w\left[ \overrightarrow{B}\left( \Delta t\right) \right] = \left( \frac{1}{% 4\pi q\Delta t}\right) ^{\frac{3}{2}}\exp \left( -\frac{\left| \overrightarrow{B}\left( \Delta t\right) \right| ^{2}}{4q\Delta t}\right) \label{w(B)}$$ and in view of $\overrightarrow{s}_{j}=\psi _{j} \overrightarrow{B}\left( \Delta t\right) $ by performing the change of variables in (\[w(B)\]) we get $$\widetilde{w}\left[ \overrightarrow{s}_{j}\right] = \det \left[ \psi _{j}^{-1}% \right] w\left[ \psi _{j}^{-1}\overrightarrow{s}_{j}\right] = \frac{1}{\det \psi _{j}}w\left[ \psi _{j}^{-1}\overrightarrow{s}_{j}\right] \enspace .$$ Since $ \det \psi \left( s\right) =e^{-3\beta \left( t-s\right) } $ and $\psi ^{-1}\left( s\right) = U\left[ -\left( t-s\right) \right] e^{\beta \left( t-s\right) }$ we obtain $$\widetilde{w}\left[ \overrightarrow{s}_{j}\right] =\left( \frac{1}{4\pi q\Delta t}\right) ^{\frac{3}{2}}\frac{1}{e^{-3\beta \left( t-j\Delta t\right) }}\exp \left( -\frac{\left| e^{\beta \left( t-j\Delta t\right) }U% \left[ -\left( t-j\Delta t\right) \right] \overrightarrow{s}_{j}\right| ^{2}% }{4q\Delta t}\right)$$ and finally $$\widetilde{w}\left[ \overrightarrow{s}_{j}\right] = \left( \frac{1}{4\pi q\Delta t}\frac{1}{e^{-2\beta \left( t-j\Delta t\right) }} \right) ^{\frac{3}{% 2}}\exp \left( -\frac{\left| \overrightarrow{s}_{j} \right| ^{2}}{4q\Delta te^{-2\beta \left( t-j\Delta t\right) }}\right) \enspace .$$ Clearly, $\overrightarrow{s}_{j}$ are mutually independent random variables whose distribution is Gaussian with mean zero and variance $\sigma _{j}^{2}=2q\Delta te^{-2\beta \left( t-j\Delta t\right) }$. Hence, the probability distribution of $\overrightarrow{S}= \sum_{j=0}^{N-1}% \overrightarrow{s}_{j}$ is again Gaussian with mean zero. Its variance equals the sum of variances of $\overrightarrow{s}_{j}$ i.e. $ \sigma ^{2}=\sum_{j}\sigma _{j}^{2}=2q\sum_{j}\Delta te^{-2\beta \left( t-j\Delta t\right) }$. After taking the limit $N\rightarrow \infty $ $(\Delta t\rightarrow 0)$ we arrive at $$\sigma ^{2}=2q\int_{0}^{t}dse^{-2\beta \left( t-s\right) }= \frac{k_{B}T}{m}% \left( 1-e^{-2\beta t}\right) \enspace .$$ Because of $\overrightarrow{S}=\overrightarrow{u} \left( t\right) -e^{-\Lambda t}% \overrightarrow{u}_{0}$ the transition probability density of the Brownian particle velocity, conditioned by the initial data $\overrightarrow{u}_0$ at $t_0=0$ reads $$P\left( \overrightarrow{u},t|\overrightarrow{u}_{0}\right) = \left( \frac{1}{% 2\pi \frac{k_{B}T}{m}\left( 1-e^{-2\beta t}\right) } \right) ^{\frac{3}{2}% }\exp \left( -\frac{\left| \overrightarrow{u}- e^{-\Lambda t}\overrightarrow{u% }_{0}\right| ^{2}}{2\frac{k_{B}T}{m}\left( 1-e^{-2\beta t}\right) } \right) \enspace .$$ The process is Markovian and time-homogeneous, hence the above formula can be trivially extended to encompass the case of arbitrary $t_{0}\neq 0$ : $ P\left( \overrightarrow{u},t|\overrightarrow{u}_{0},t_{0}\right)$ arises by substituting everywhere $t-t_0$ instead of $t$. Physical arguments (cf. demand (ii) preceding Eq. (4)) refer to an asymptotic probability distribution (invariant measure density) $P(u)$ of the random variable $\overrightarrow{u}$ in the Maxwell-Boltzmann form $$P\left( \overrightarrow{u}\right) =\left( \frac{m}{2\pi k_{B}T} \right) ^{\frac{3}{2}}\exp \left( -\frac{m\left| \overrightarrow{u}\right| ^{2}}{2k_{B}T}\right) \enspace .$$ This time-independent probability density together with the time-homogeneous transition density (15) uniquely determine a stationary Markovian stochastic process for which we can evaluate various mean values. Expectation values of velocity components vanish: $ \left\langle u_{i}\left( t\right) \right\rangle = \int_{-\infty }^{\infty }u_{i}P\left( \overrightarrow{u}\right) d\overrightarrow{u}=0 $ for $i=1,2,3$. The matrix of the second moments (velocity auto-correlation functions) reads $$\left\langle u_{i}\left( t\right) u_{j}\left( t_{0}\right) \right\rangle =\int_{-\infty }^{\infty }u_{i}u_{j}^{0}P\left( \overrightarrow{u},t;% \overrightarrow{u}_{0},t_{0}\right) d\overrightarrow{u}d\overrightarrow{u}% _{0}$$ where $i,j=1,2,3$ and in view of $ P\left( \overrightarrow{u},t;\overrightarrow{u}_{0},t_{0}\right) = P\left( \overrightarrow{u},t|\overrightarrow{u}_{0},t_{0}\right) P\left( \overrightarrow{u}_{0}\right)$ we arrive at the compact expression $$\frac{k_{B}T}{m}e^{-\Lambda \left| t-t_{0}\right| }=\frac{k_{B}T}{m}% e^{-\beta \left| t-t_{0}\right| }\left( \begin{array}{ccc} \cos \omega _{c}\left| t-t_{0}\right| & \sin \omega _{c}\left| t-t_{0}\right| & 0 \\ -\sin \omega _{c}\left| t-t_{0}\right| & \cos \omega _{c}\left| t-t_{0}\right| & 0 \\ 0 & 0 & 1 \end{array} \right) \enspace .$$ In particular, the auto-correlation function (second moment) of the $x$-component of velocity equals $$\left\langle u_{1}\left( t\right) u_{1}\left( t_{0}\right) \right\rangle =% \frac{k_{B}T}{m}e^{-\beta \left| t-t_{0}\right| }\cos \omega _{c}\left| t-t_{0}\right| \label{autocor}$$ in agreement with white noise calculations of Refs. [@Tay] and [@Bal], cf. Chap.11, formula (11.25). The so-called running diffusion coefficient arises here via straightforward integration of the function $R_{11}(\tau )= <u_1(t)u_1(t_0)>$ where $\tau = t-t_0 >0$: $$D_1(t) = \int_0^t <u_1(0)u_1(\tau)> d\tau = % {{k_BT}\over m} {{\beta + [\omega _csin(\omega _ct) - \beta cos(\omega _ct)]exp(-\beta t)}\over {\beta ^2 + {\omega _c}^2}}$$ with an obvious asymptotics (the same for $D_2(t)$): $D_B=lim_{t\rightarrow \infty } D_1(t)= {{k_BT}\over m} {\beta \over {\beta ^2 + {\omega _c}^2}}$ and the large friction ($\omega _c$ fixed and bounded) version $D= {{k_BT}\over {m\beta }}$. Spatial process - dynamics in the plane ======================================= The cylindrical symmetry of the problem allows us to consider separately processes running on the $XY$ plane and along the $Z$-axis (where the free Brownian motion takes place). We shall confine further attention to the two-dimensional $XY$-plane problem. Henceforth, each vector will carry two components which correspond to the $x$ and $y$ coordinates respectively. We will directly refer to the vector and matrix quantities introduced in the previous section, but while keeping the same notation, we shall simply disregard their $z$-coordinate contributions. We define the spatial displacement $\overrightarrow{r}$ of the Brownian particle as folows $$\overrightarrow{r}-\overrightarrow{r}_{0}=\int_{0}^{t} \overrightarrow{u}% \left( \eta \right) dn$$ where $\overrightarrow{u}\left( t\right) $ is given by Eq. (\[LanII\]) (except for disregarding the third coordinate). Our aim is to derive the probability distribution of $\overrightarrow{r}$ at time $t$ provided that the particle position and velocity were equal $\overrightarrow{r}_{0}$ and $\overrightarrow{u}_{0}$ respectively, at time $t_{0}=0$. To that end we shall mimic procedures of the previous section. In view of: $$\overrightarrow{r}-\overrightarrow{r}_{0}- \int_{0}^{t}e^{-\Lambda \eta }% \overrightarrow{u}_{0}=\int_{0}^{t}d\eta \int_{0}^{\eta }dse^{-\Lambda \left( \eta -s\right) }\overrightarrow{A}\left( s\right)$$ we have $$\overrightarrow{r}-\overrightarrow{r}_{0}- \Lambda ^{-1}\left( 1-e^{-\Lambda t}\right) \overrightarrow{u}_{0}=\int_{0}^{t}\Lambda ^{-1}\left( 1-e^{\Lambda \left( s-t\right) }\right) \overrightarrow{A}\left( s\right) ds$$ where $$\Lambda ^{-1}=\frac{1}{\beta ^{2}+\omega _{c}^{2}}\left( \begin{array}{cc} \beta & \omega _{c} \\ -\omega _{c} & \beta \end{array} \right)$$ is the inverse of the matrix $\Lambda $ (regarded as a rank two sub-matrix of that originally introduced in Eq. (3)). Let us define two auxiliary matrices $$\begin{aligned} \Omega &\equiv &\Lambda ^{-1}\left( 1-e^{-\Lambda t}\right) \label{omega} \\ \phi \left( s\right) &\equiv &\Lambda ^{-1}\left( 1-e^{\Lambda \left( s-t\right) }\right) \notag \enspace .\end{aligned}$$ Because of: $$e^{-\Lambda t}=\exp \left\{ - t \left( \begin{array}{cc} \beta & -\omega _{c} \\ \omega _{c} & \beta \end{array} \right) \right\} =e^{-\beta t}\left( \begin{array}{cc} \cos \omega _{c}t & \sin \omega _{c}t \\ -\sin \omega _{c}t & \cos \omega _{c}t \end{array} \right) =e^{-\beta t}U\left( t\right)$$ we can represent matrices $\Omega $, $\phi \left( s\right) $ in more detailed form. We have: $$\Omega =\frac{1}{\beta ^{2}+\omega _{c}^{2}}\left\{ \left( \begin{array}{cc} \beta & \omega _{c} \\ -\omega _{c} & \beta \end{array} \right) -e^{-\beta t}\left( \begin{array}{cc} \beta & \omega _{c} \\ -\omega _{c} & \beta \end{array} \right) \left( \begin{array}{cc} \cos \omega _{c}t & \sin \omega _{c}t \\ -\sin \omega _{c}t & \cos \omega _{c}t \end{array} \right) \right\}$$ and $$\phi \left( s\right) =\Lambda ^{-1}\left( 1-e^{-\beta \left( t-s\right) }U\left( t-s\right) \right) =$$ $$\frac{1}{\beta ^{2}+\omega _{c}^{2}}\left( \begin{array}{cc} \beta & \omega _{c} \\ -\omega _{c} & \beta \end{array} \right) \left( \begin{array}{cc} 1-e^{\beta \left( s-t\right) }\cos \omega _{c}\left( s-t\right) & -e^{\beta \left( s-t\right) }\sin \omega _{c}\left( s-t\right) \\ e^{\beta \left( s-t\right) }\sin \omega _{c}\left( s-t\right) & 1-e^{\beta \left( s-t\right) }\cos \omega _{c}\left( s-t\right) \end{array} \right) \enspace .$$ Next steps imitate procedures of the previous section. Thus, we seek for the probability distribution of the random (planar) vector $ \overrightarrow{R}=\int_{0}^{t}\phi \left( s\right) \overrightarrow{A}\left( s\right) ds \label{Rdef}$ where $\overrightarrow{R}=\overrightarrow{r}-\overrightarrow{r}_{0}-\Omega \overrightarrow{u}_{0}$. Dividing the time interval $\left( 0,t\right) $ into small subintervals to assure that $\phi \left( s\right) $ can be regarded constant over the time span $\left( j\Delta t,\left( j+1\right) \Delta t\right) $ and equal $\phi \left( j\Delta t\right) $, we obtain $$\overrightarrow{R}=\sum_{j=0}^{N-1}\phi \left( j\Delta t\right) \int_{j\Delta t}^{\left( j+1\right) \Delta t}\overrightarrow{A}\left( s\right) ds=\sum_{j=0}^{N-1}\phi \left( j\Delta t\right) \overrightarrow{B}% \left( \Delta t\right) =\sum_{j=0}^{N-1}\overrightarrow{r}_{j}$$ where $\overrightarrow{r}_{j}=\phi \left( j\Delta t\right) \overrightarrow{B}\left( \Delta t\right) =\phi _{j}\overrightarrow{B}\left( \Delta t\right) $. By invoking the probability distribution (10) we perform an appropriate change of variables: $\overrightarrow{r% }_{j}=\phi _{j}\overrightarrow{B}\left( \Delta t\right) $ to yield a probability distribution of $\overrightarrow{r}_{j}$ $$\widetilde{w}\left[ \overrightarrow{r}_{j}\right] = \det \left[ \phi _{j}^{-1}% \right] w\left[ \phi _{j}^{-1}\overrightarrow{r}_{j}\right] =\frac{1}{\det \phi _{j}}w\left[ \phi _{j}^{-1}\overrightarrow{r}_{j}\right] \enspace .$$ Presently (not to be confused with previous steps (11)-(15)) we have $$\det \phi \left( s\right) =\frac{1}{\beta ^{2}+\omega _{c}^{2}}\left( 1+e^{2\beta \left( s-t\right) }-2e^{\beta \left( s-t\right) }\cos \omega _{c}\left( s-t\right) \right)$$ and $$\phi ^{-1}\left( s\right) =\frac{1}{1+e^{2\beta \left( s-t\right) }-2e^{\beta \left( s-t\right) }\cos \omega _{c}\left( s-t\right) }\left[ 1-e^{\beta \left( s-t\right) }U\left( -\left( s-t\right) \right) \right] \Lambda \enspace .$$ So, the inverse of the matrix $\phi _{j}$ has the form: $$\phi _{j}^{-1}=\frac{\widetilde{A}_{j}}{\gamma _{j}}$$ where $$\widetilde{A}_{j}=\left( \begin{array}{cc} 1-e^{\beta \left( j\Delta t-t\right) }\cos \omega _{c}\left( j\Delta t-t\right) & e^{\beta \left( j\Delta t-t\right) }\sin \omega _{c}\left( j\Delta t-t\right) \\ -e^{\beta \left( j\Delta t-t\right) }\sin \omega _{c}\left( j\Delta t-t\right) & 1-e^{\beta \left( j\Delta t-t\right) }\cos \omega _{c}\left( j\Delta t-t\right) \end{array} \right) \left( \begin{array}{cc} \beta & -\omega _{c} \\ \omega _{c} & \beta \end{array} \right)$$ and $$\gamma _{j}=1+e^{2\beta \left( j\Delta t-t\right) }-2e^{\beta \left( j\Delta t-t\right) }\cos \omega _{c}\left( j\Delta t-t\right) \enspace .$$ There holds: $$\det \phi _{j}^{-1}=\left( \det \phi _{j}\right) ^{-1}=\left( \beta ^{2}+\omega _{c}^{2}\right) \frac{1}{\gamma _{j}}$$ and as a consequence we arrive at the following probability distribution of $\overrightarrow{r}_{j}$ $$\widetilde{w}\left[ \overrightarrow{r}_{j}\right] = \frac{1}{\frac{1}{\beta ^{2}+\omega _{c}^{2}}\gamma _{j}}\left( \frac{1}{4\pi q\Delta t} \right) \exp \left\{ \frac{\left| \widetilde{A}_{j}\left( \begin{array}{c} r_{j}^{x} \\ r_{j}^{y} \end{array} \right) \right| ^{2}}{\gamma _{j}^{2}4q\Delta t}\right\} \enspace .$$ In view of $$\left| \widetilde{A}_{j}\left( \begin{array}{c} r_{j}^{x} \\ r_{j}^{x} \end{array} \right) \right| ^{2}=\left( \beta ^{2}+ \omega _{c}^{2}\right) \gamma _{j}% \left[ \left( r_{j}^{x}\right) ^{2}+ \left( r_{j}^{y}\right) ^{2}\right]$$ that finally leads to $$\widetilde{w}\left[ \overrightarrow{r}_{j}\right] = \left( \frac{\beta ^2 + \omega _{c}^2}{4\pi q\Delta t \gamma _{j}}\right) \exp \left\{ -\frac{(\beta ^2 + \omega _{c}^2)\, \left| \overrightarrow{r}_{j}\right| ^{2}} {4q\Delta t \gamma _{j}}\right\} \enspace .$$ Since this probability distribution is Gaussian with mean zero and variance $% \sigma _{j}^{2}=$ $2q\Delta t\frac{1}{\beta ^{2}+\omega _{c}^{2}} \gamma _{j}$, the random vector$\ \overrightarrow{R}$ as a sum of independent random variables $\overrightarrow{r}_{j}$ has the distribution $$w\left( \overrightarrow{R}\right) =\frac{1}{2\pi \sum_{j} \sigma _{j}^{2}}% \exp \left( -\frac{R_{x}^{2}+R_{y}^{2}}{2\sum_{j} \sigma _{j}^{2}}\right) \enspace .$$ $$\sigma ^{2}=\sum_{j}\sigma _{j}^{2}=2q\sum_{j}\Delta t\frac{1}{\beta ^{2}+\omega _{c}^{2}}\gamma _{j} \enspace .$$ In the limit of $\Delta t\rightarrow 0$ we arrive at the integral $$\sigma ^{2}=2q\frac{1}{\beta ^{2}+\omega _{c}^{2}} \int_{0}^{t}\gamma \left( s\right) ds$$ with $ \int_{0}^{t}\gamma \left( s\right) ds=t+ \Theta $, where $$\Theta = \Theta (t) = \frac{1}{2\beta }\left( 1-e^{-2\beta t}\right) -2\frac{1}{\beta ^{2}+\omega _{c}^{2}}\left[ \beta +\left( \omega _{c}\sin \omega _{c}t-\beta \cos \omega _{c}t\right) e^{-\beta t}\right] \enspace .$$ That gives rise to an ultimate form of the transition probability density of the spatial displacement process: $$P\left( \overrightarrow{r},t|\overrightarrow{r}_{0},t_{0}=0, \overrightarrow{u% }_{0}\right) =\frac{1}{4\pi \frac{k_{B}T}{m}\frac{\beta } {\beta ^{2}+\omega _{c}^{2}}\left( t+\Theta \right) }\exp \left( - \frac{\left| \overrightarrow{r% }-\overrightarrow{r}_{0}-\Omega \overrightarrow{u}_{0} \right| ^{2}}{4\frac{% k_{B}T}{m}\frac{\beta }{\beta ^{2}+\omega _{c}^{2}} \left( t+\Theta \right) }% \right)$$ with $\Omega =\Omega (t)$ defined in Eqs. (\[omega\]), (27). Notice that an asymptotic diffusion coefficient $D_B=D{\beta^2\over {\beta ^2 + \omega ^2_c}}$ encodes an attenuation signature for the spatial dispersion (when $\omega _c$ grows up at $\beta $ fixed). The spatial displacement process governed by the above transition probability density surely is *not Markovian. That can be checked by inspection: the Chapman-Kolmogorov identity is not valid, like in the standard free Brownian motion example where the Ornstein-Uhlenbeck process induced (sole) spatial dynamics is non-Markovian as well.* Phase-space process =================== Axial direction --------------- We take advantage of the cylindrical symmetry of our problem, and consider separately the (free) Brownian dynamics in the direction parallel to the magnetic field vector, e.g. along the $Z$-axis. That amounts to a familiar Ornstein-Uhlenbeck process in its extended phase-space form. In the absence of external forces, the kinetic (Kramers-Fokker-Planck equation) reads: $${\partial _t W + u\nabla _zW = \beta \nabla _u(Wu) + q \triangle _uW}$$ where $q=D\beta ^2$. Here $\beta $ is the friction coefficient, $D$ will be identified later with the spatial diffusion constant, and (as before) we set $D=k_BT/m\beta $ in conformity with the Einstein fluctuation-dissipation identity. The joint probability distribution (in fact, density) $W(z,u,t)$ for a freely moving Brownian particle which at $t=0$ initiates its motion at $x_0$ with an arbitrary inital velocity $u_0$ can be given in the form of the maximally symmetric displacement probability law: $$W(z,u,t)= W(R,S) = [4\pi ^2(FG-H^2)]^{-1/2} \cdot exp\{ - {{GR^2 - HRS + FS^2}\over {2(FG - H^2)}}\}$$ where $R=z-u_0(1-e^{-\beta t})\beta ^{-1}$, $S=u-u_0e^{-\beta t}$ while $ F = {D\over \beta }(2\beta t - 3 +4e^{-\beta t}- e^{-2\beta t})$ $G=D\beta (1-e^{-2\beta t})$ and $H=D(1-e^{-\beta t})^2$. Planar process -------------- Now we shall consider Brownian dynamics in the direction perpendicular to the magnetic field $\overrightarrow{B}$, hence (while in terms of configuration-space variables) we address an issue of the planar dynamics. We are interested in the complete phase-space process, hence we need to specify the transition probability density  $P\left( \overrightarrow{r},\overrightarrow{u},t|\overrightarrow{r}_{0},% \overrightarrow{u}_{0},t_{0}=0\right) $ of the Markov process conditioned by the initial data $\overrightarrow{u}=% \overrightarrow{u}_{0}$ and $\overrightarrow{r}= \overrightarrow{r}_{0}$ at time $% t_{0}=0$. That is equivalent to deducing the joint probability distribution $W\left( \overrightarrow{S,}% \overrightarrow{R}\right) $ of random vectors $\overrightarrow{S}$ and $% \overrightarrow{R}$, previously defined to appear in the form $\overrightarrow{S}=\overrightarrow{u} \left( t\right) -e^{-\Lambda t}% \overrightarrow{u}_{0}$ and $\overrightarrow{R}=\overrightarrow{r}-\overrightarrow{r}_{0}- \Omega \overrightarrow{u}_{0}$ respectively. Let us stress that presently, all vectors are regarded as two-dimensional versions (the third component being simply disregarded) of the original random variables we have discussed so far in Sections 2 and 3. Vectors $\overrightarrow{S}$ and $\overrightarrow{R}$ both share a Gaussian distribution with mean zero. Consequently, the joint distribution $W\left( \overrightarrow{S,}\overrightarrow{R}\right) $ is determined by the matrix of variances and covariances: $C = \left( c_{ij}\right) = \left(\left\langle x_{i}x_{j}\right\rangle \right)$, where we abbreviate four phase-space variables in a single notion of $x=\left( S_{1},S_{2},R_{1},R_{2}\right) $ and label components of $x$ by $i,j=1,2,3,4$. In terms of $\overrightarrow{R}$ and $\overrightarrow{S}$ the covariance matrix $C$ reads: $$C=\left( \begin{array}{cccc} \left\langle S_{1}S_{1}\right\rangle & \left\langle S_{1}S_{2}\right\rangle & \left\langle S_{1}R_{1}\right\rangle & \left\langle S_{1}R_{2}\right\rangle \\ \left\langle S_{2}S_{1}\right\rangle & \left\langle S_{2}S_{2}\right\rangle & \left\langle S_{2}R_{1}\right\rangle & \left\langle S_{2}R_{2}\right\rangle \\ \left\langle R_{1}S_{1}\right\rangle & \left\langle R_{1}S_{2}\right\rangle & \left\langle R_{1}R_{1}\right\rangle & \left\langle R_{1}R_{2}\right\rangle \\ \left\langle R_{2}S_{1}\right\rangle & \left\langle R_{2}S_{2}\right\rangle & \left\langle R_{2}R_{1}\right\rangle & \left\langle R_{2}R_{2}\right\rangle \end{array} \right) \enspace .$$ The joint probability distribution of $\overrightarrow{S}$ and $% \overrightarrow{R}$ is given by $$W\left( \overrightarrow{S,}\overrightarrow{R}\right) =W\left( \overrightarrow{x}\right) =\frac{1}{4\pi ^{2}} \left( \frac{1}{\det C}\right)^{\frac{1}{2}}\exp \left( -\frac{1}{2}\sum_{i,j}c_{ij}^{-1}x_{i}x_{j}\right)$$ where $c_{ij}^{-1}$denotes the component of the inverse matrix $C^{-1}$. The probability distributions of $\overrightarrow{S}$ and $\overrightarrow{R} $, which were established in the previous sections, determine a number of expectation values: $$g\equiv \left\langle S_{1}S_{1}\right\rangle =\left\langle S_{2}S_{2}\right\rangle =\frac{k_{B}T}{m}\left( 1-e^{-2\beta t}\right)$$ while $ \left\langle S_{1}S_{2}\right\rangle = \left\langle S_{2}S_{1}\right\rangle =0$. Furthermore: $$f\equiv \left\langle R_{1}R_{1}\right\rangle =\left\langle R_{2}R_{2}\right\rangle =2\frac{k_{B}T}{m}\frac{\beta } {\beta ^{2}+\omega _{c}^{2}}\left( t+\Theta \right)= 2D_B (t+\Theta ) \, .$$ In addition we have $ \left\langle R_{1}R_{2}\right\rangle =\left\langle R_{2}R_{1}\right\rangle =0$. As a consequence, we are left with only four non-vanishing components of the covariance matrix $C$: $ c_{13}=c_{31}=\left\langle S_{1}R_{1}\right\rangle $, $ c_{14}=c_{41}=\left\langle S_{1}R_{2}\right\rangle $, $ c_{23}=c_{32}=\left\langle S_{2}R_{1}\right\rangle $, $ c_{24}=c_{42}=\left\langle S_{2}R_{2}\right\rangle $ which need a closer examination. We can obtain those covariances by exploiting a dependence of the random quantities $% \overrightarrow{S}$ and $\overrightarrow{R}$ on the white-noise term $% \overrightarrow{A}\left( s\right) $ whose statistical properties are known. There follows: $$S_{1}=\int_{0}^{t}dse^{-\beta \left( t-s\right) }\left[ \cos \omega _{c}\left( t-s\right) A_{1}\left( s\right) +\sin \omega _{c}\left( t-s\right) A_{2}\left( s\right) \right]$$ $$S_{2}=\int_{0}^{t}dse^{-\beta \left( t-s\right) }\left[ -\sin \omega _{c}\left( t-s\right) A_{1}\left( s\right) +\cos \omega _{c}\left( t-s\right) A_{2}\left( s\right) \right]$$ $$\begin{aligned} R_{1} &=&\int_{0}^{t}ds\frac{1}{\beta ^{2}+\omega _{c}^{2}}\left[ \beta \left( 1-e^{-\beta \left( t-s\right) }\cos \omega _{c}\left( t-s\right) \right) +\omega _{c}e^{-\beta \left( t-s\right) }\sin \omega _{c}\left( t-s\right) \right] A_{1}\left( s\right) + \\ & &\int_{0}^{t}ds\frac{1}{\beta ^{2}+\omega _{c}^{2}}\left[ -\beta e^{-\beta \left( t-s\right) }\sin \omega _{c}\left( t-s\right) +\omega _{c}\left( 1-e^{-\beta \left( t-s\right) }\cos \omega _{c} \left( t-s\right) \right) % \right] A_{2}\left( s\right)\end{aligned}$$ $$\begin{aligned} R_{2} &=&\int_{0}^{t}ds\frac{1}{\beta ^{2}+\omega _{c}^{2}} \left[ -\omega _{c}\left( 1-e^{-\beta \left( t-s\right) } \cos \omega _{c}\left( t-s\right) \right) +\beta e^{-\beta \left( t-s\right) }\sin \omega _{c}\left( t-s\right) \right] A_{1}\left( s\right) + \\ &&\int_{0}^{t}ds\frac{1}{\beta ^{2}+\omega _{c}^{2}}\left[ \omega _{c}e^{-\beta \left( t-s\right) }\sin \omega _{c} \left( t-s\right) +\beta \left( 1-e^{-\beta \left( t-s\right) }\cos \omega _{c} \left( t-s\right) \right) \right] A_{2}\left( s\right) \enspace .\end{aligned}$$ Multiplying together suitable components of vectors $\overrightarrow{S}$ and $\overrightarrow{R}$ and taking averages of those products in conformity with the rules $\left\langle A_{i}\left( s\right) \right\rangle =0$ and $% \left\langle A_{i}\left( s\right) A_{j}\left( s^{\shortmid }\right) \right\rangle =2q\delta _{ij}\delta \left( s-s^{\shortmid }\right) $, where $% q=\frac{k_{B}T}{m}\beta $, $i,j=1,2,3$, we arrive at: $$h\equiv \left\langle R_{1}S_{1}\right\rangle = \left\langle R_{2}S_{2}\right\rangle =2q\frac{1}{\beta ^{2}+ \omega _{c}^{2}} \int_{0}^{t}ds e^{-\beta \left( t-s\right) } [ \beta \cos \omega _{c}\left( t-s\right) +$$ $$\omega _{c}\sin \omega _{c} \left( t-s\right) -\beta e^{-\beta \left( t-s\right) }] =q\frac{1}{\beta ^{2}+\omega _{c}^{2}} \left( 1-2e^{-\beta t}\cos \omega _{c}t+e^{-2\beta t}\right)$$ and $$k\equiv \left\langle R_{1}S_{2}\right\rangle =-\left\langle R_{2}S_{1}\right\rangle =2q\frac{1}{\beta ^{2}+\omega _{c}^{2}}% \int_{0}^{t}dse^{-\beta \left( t-s\right) }[ -\beta \sin \omega _{c}\left( t-s\right) +$$ $$\omega _{c}\cos \omega _{c} \left( t-s\right) -\omega _{c}e^{-\beta \left( t-s\right) }] = q\frac{1}{\beta ^{2}+\omega _{c}^{2}}\left[ 2e^{-\beta t}\sin \omega _{c}t-\frac{\omega _{c}}{\beta }\left( 1-e^{-2\beta t}\right) \right] \enspace .$$ The covariance matrix $C=\left( c_{ij}\right) $ has thus the form $$C=\left( \begin{array}{cccc} g & 0 & h & -k \\ 0 & g & k & h \\ h & k & f & 0 \\ -k & h & 0 & f \end{array} \right)$$ while its inverse $C^{-1}$ reads as follows: $$C^{-1}=\frac{1}{\det C}\left( fg-h^{2}-k^{2}\right) \left( \begin{array}{cccc} f & 0 & -h & k \\ 0 & f & -k & -h \\ -h & -k & g & 0 \\ k & -h & 0 & g \end{array} \right)$$ where $ \det C=\left( fg-h^{2}-k^{2}\right) ^{2}$. The joint probability distribution of $\overrightarrow{S}$ and $% \overrightarrow{R}$ can be ultimately written in the form: $$W\left( \overrightarrow{S},\overrightarrow{R}\right) =$$ $$\frac{1}{4\pi ^{2}\left( fg-h^{2}-k^{2}\right) }\exp \left( - \frac{f\left| \overrightarrow{% S}\right| ^{2}+g\left| \overrightarrow{R}\right| ^{2}- 2h\overrightarrow{S}% \cdot \overrightarrow{R}+2k\left( \overrightarrow{S} \times \overrightarrow{R}% \right) _{i=3}}{2\left( fg-h^{2}-k^{2}\right) }\right) \enspace .$$ In the above, all vector entries are two-dimensional. The specific $i=3$ vector product coordinate in the exponent is simply an abbreviation for the (ordinary $R^3$-vector product) procedure that involves merely first two components of three-dimensional vectors (the third is then arbitrary and irrelevant), hence effectively involves our two-dimensional $\overrightarrow{R}$ and $\overrightarrow{S}$.\ [**Acknowledgement:**]{} One of the authors (P. G.) receives financial support from the KBN research grant No. 2 PO3B 086 16. [99]{} J. B. Taylor, Phys. Rev. Lett. **6**, 262, (1961) B. Kurşunoǧlu, Ann. Phys. **17**, 259, (1962) R. Balescu, *Statistical Dynamics. Matter out of Equilibrium*. (Imperial College Press, London, 1997) Z. Schuss, *Theory and Applications of Stochastic Differential Equations*, (Wiley, NY, 1980) N. G. van Kampen, *Stochastic Processes in Physics and Chemistry*, (North Holland, Amsterdam, 1981) S. Stepanov, Phys. Rev. E **54**, 2209, (1996) S. Chandrasekhar, Rev. Mod. Phys. **15**, 1, (1943) E. Nelson, *Dynamical Theories of Brownian Motion*, (Princeton University Press, Princeton, 1967) J. L. Doob, Ann. Math. **43**, 351, (1942)

Specifications tableSubject areaInternal and Cardiovascular MedicineMore specific subject areaOral anticoagulation in patients aged 90 years or older with atrial fibrillationType of dataTables and FiguresHow data was acquiredDocument analysis were retrospectively and prospectively collectedData formatRaw, analyzedExperimental factorsPatients aged 90 years or older with non-valvular atrial fibrillation treated with oral anticoagulants were included. Patients on direct oral anticoagulants were derived from a prospective multicentre registry while patients on vitamin-K antagonists from the Anticoagulation Clinic of the University Hospital in Perugia.Experimental featuresData on ischemic stroke and systemic embolism, major bleeding, permanent discontinuation and all-cause death were i) prospectively collected in patients treated with direct oral anticoagulants through every-6-month visits and ii) retrospectively collected since the start of anticoagulant treatment or when the patient became 90 years of age or older in nonagenarians treated with vitamin-K antagonists\ A time-to-event analysis taking competing risk by death into account was performed.Data source locationDepartment of Internal and Cardiovascular Medicine, Perugia, Italy.Data accessibilityThe data are with this article.Related research articleGiustozzi M, Vedovati MC, Verso M, Scrucca L, Verdecchia P, Conti S et al. Patients aged 90 years or older with atrial fibrillation treated with oral anticoagulants: A multicentre observational study. Int J Cardiol 2018; in press [@bib1].**Value of the data**•The data presented in this article provide original information and increase knowledge on the use of oral anticoagulants in patients aged 90 years or older with atrial fibrillation.•The data can be used by clinicians and researchers to generate hypothesis for further studies and as reference.•These data could support the decision making process on the use of oral anticoagulation in patients aged 90 years or older. 1. Data {#sec1} ======= The dataset of this article comprises five data files that were generated from further analysis of 546 patients aged 90 years or older with atrial fibrillation treated with oral anticoagulants. [Fig. 1](#fig1){ref-type="fig"} shows the selection of the population with the number of patients divided according to type \[direct oral anticoagulants (DOAC) or vitamin-K antagonist (VKA)\] and duration (already on anticoagulant or naïve) of oral anticoagulation. The time course of ischaemic stroke/TIA and systemic embolism (panel A) and for major bleeding (panel B) according to the presence of outcome predictors are given in [Fig. 2](#fig2){ref-type="fig"}. Main causes of permanent discontinuation in the overall population and according to the type of anticoagulation received are shown in [Table 1](#tbl1){ref-type="table"}. The same table reports the percentages of patients that discontinued anticoagulants or died and the annual incidence rates of discontinuation and death. Data on hazard ratios and subdistribution hazard ratios of main predictors for permanent discontinuation are reported in [Fig. 3](#fig3){ref-type="fig"}. [Table 2](#tbl2){ref-type="table"} shows data on comparisons of sub-group of patients, specifically i) oral anticoagulant naïve users vs. long-term oral anticoagulant users and ii) patients on anticoagulant therapy for less than 2 years (new users) vs. patients on anticoagulant therapy for more than 2 years. Here, we report data in the overall population and according to treatment group.Fig. 1Flow-chart of patients.Fig. 1Fig. 2Time course of and main predictors for ischaemic stroke/TIA/systemic embolism and major bleeding.Fig. 2Table 1Main causes of permanent discontinuation and of all-cause death in the overall population and according to the type of anticoagulation.Table 1VariableAll patients (n = 546)VKAs patients (n = 301)DOACs patients (n = 245)Permanent discontinuation, n (%)957223(17%; 10.4% pts-y)(24%; 10.9% pts-y)(9%; 8.9% pts-y)Main causes Bleeding413011 Physician/patient\'s decision20146 High risk of falls550 Poor adherence550 Cancer440 Renal failure202 Unknown14122 Other422Death, n (%)1469749(16.0% pts-y)(14.8% pts-y)(19.1% pts-y) Fatal bleeding954 Fatal ischemic stroke211 Fatal AMI312Fig. 3Main predictors for permanent discontinuation.Fig. 3Table 2Data on comparisons of sub-group of patients: i) anticoagulation naïve vs. anticoagulation non-naïve patients, ii) new users vs. non-new users.Table 2Outcome eventIschaemic stroke/TIA/SEMajor bleedingAll-cause deathPermanent discontinuationSHR, 95% CISHR, 95% CISHR, 95% CISHR, 95% CIAnticoagulation naïve1.85 (0.55--6.24)1.24 (0.47--3.31)1.23 (0.52--2.93)1.63 (0.81--3.28)DOAC[a](#tbl2fna){ref-type="table-fn"} Anticoagulation naïve0.19 (0.03--1.40)1.12 (0.27--4.60)0.62 (0.25--1.54)0.76 (0.26--2.24)New users1.37 (0.51--3.71)1.62 (0.78--3.36)1.10 (0.68--1.79)1.10 (0.66--1.82)DOAC[a](#tbl2fna){ref-type="table-fn"} new users0.27 (0.04--1.72)0.86 (0.24--3.00)0.67 (0.33--1.38)1.07 (0.40--2.85)[^1] 2. Experimental design, materials and methods {#sec2} ============================================= Data on DOAC patients were derived from a multicentre prospective Italian registry of atrial fibrillation patients [@bib2] while data on VKA patients were retrospectively derived from the database of the Anticoagulation Clinic of Perugia. For both group, data were collected since time of anticoagulation prescription or since the patient became 90 years old. Follow-up was performed every 6 months by visits or telephone contacts in the DOAC group while follow-up was retrospectively retrieved in the VKA group. Due to the expected high mortality of study patients, we performed a time-to-event analyses taking death as competing risk. We calculated the cumulative incidences and the risks of a) ischemic stroke/TIA and systemic embolism; b) major bleeding; c) permanent discontinuation. Data were reported as sub-distribution hazard ratios (SHR) and 95% confidence interval. Statistical analysis was performed using R 3.5.0. Transparency document {#appsec1} ===================== The following is the transparency document related to this article:Multimedia component 1Multimedia component 1 The authors thank all the clinicians who participated in this project and provided data for this data article, and the patients included in the study for their trust and support. Transparency document associated with this article can be found in the online version at <https://doi.org/10.1016/j.dib.2019.103794>. [^1]: Anticoagulation naive patients treated with DOACs compared with anticoagulation naive patients treated with VKAs.

Program death-1 engagement upon TCR activation has distinct effects on costimulation and cytokine-driven proliferation: attenuation of ICOS, IL-4, and IL-21, but not CD28, IL-7, and IL-15 responses. The program death 1 (PD-1) receptor and its ligands, PD-1 ligand (PD-L)1 and PD-L2, define a novel regulatory pathway with potential inhibitory effects on T, B, and monocyte responses. In the present study, we show that human CD4(+) T cells express PD-1, PD-L1, and PD-L2 upon activation, and Abs to the receptor can be agonists or antagonists of the pathway. Under optimal conditions of stimulation, ICOS but not CD28 costimulation can be prevented by PD-1 engagement. IL-2 levels induced by costimulation are critical in determining the outcome of the PD-1 engagement. Thus, low to marginal IL-2 levels produced upon ICOS costimulation account for the greater sensitivity of this pathway to PD-1-mediated inhibition. Interestingly, exogenous IL-2, IL-7, and IL-15 but not IL-4 and IL-21 can rescue PD-1 inhibition, suggesting that among these cytokines only those that activate STAT5 can rescue PD-1 inhibition. As STAT5 has been implicated in the maintenance of IL-2Ralpha expression, these results suggest that IL-7 and IL-15 restore proliferation under conditions of PD-1 engagement by enhancing high-affinity IL-2R expression and hence, IL-2 responsiveness.

Q: UDP in C++ in Linux How to send and receive, using UDP, in C++ in Linux? I use g++ A: Using boost::asio. A: You can use Berkeley Sockets API. A: Ok it's preety simple. I was workig in CentOS 5.5 which is linux and i make a server-client programme based on udp in c.It runs well. The procedure is simple. It follows as .. **SERVER** 0.Variable initialization 1.sock() 2.bind() 3.recvfrom() 4.sendto() **CLIENT** 0.gethostbyname() 1.sock() 2.bzero() 4.sendto() 5.recvfrom() You will understand the code if you see the documentation. If its not work that way then go to >> matrixsust.blogspot.com for source.

Q: How to insert entity with many to many relation? I'm working with Spring framework. I have two entities, Movie and Actor, so a Movie can have many actors and an Actor can play in many Movie. Following we have the classes: import java.util.List; import javax.persistence.Entity; import javax.persistence.GeneratedValue; import javax.persistence.GenerationType; import javax.persistence.Id; import javax.persistence.JoinTable; import javax.persistence.ManyToMany; @Entity public class Actor { @Id @GeneratedValue(strategy = GenerationType.IDENTITY) private Long id; private String name; private String surname; private String age; @ManyToMany @JoinTable(name = "movie_actor") private List<Movie> movies; public Actor(String name, String surname, String age) { this.name = name; this.surname = surname; this.age = age; } public Long getId() { return id; } public void setId(Long id) { this.id = id; } public String getName() { return name; } public void setName(String name) { this.name = name; } public String getSurname() { return surname; } public void setSurname(String surname) { this.surname = surname; } public String getAge() { return age; } public void setAge(String age) { this.age = age; } public List<Movie> getMovies() { return movies; } public void setMovies(List<Movie> movies) { this.movies = movies; } } import java.util.List; import javax.persistence.Entity; import javax.persistence.GeneratedValue; import javax.persistence.GenerationType; import javax.persistence.Id; import javax.persistence.ManyToMany; @Entity public class Movie { @Id @GeneratedValue(strategy = GenerationType.IDENTITY) private Long id; private String title; private String genre; private String year; @ManyToMany(mappedBy = "movies") private List<Actor> actors; public Movie(String title, String genre, String year, List<Actor> actors) { this.title = title; this.genre = genre; this.year = year; this.actors = actors; } public Long getId() { return id; } public void setId(Long id) { this.id = id; } public String getTitle() { return title; } public void setTitle(String title) { this.title = title; } public String getGenre() { return genre; } public void setGenre(String genre) { this.genre = genre; } public String getYear() { return year; } public void setYear(String year) { this.year = year; } public List<Actor> getActors() { return actors; } public void setActors(List<Actor> actors) { this.actors = actors; } } I have used @ManyToMany annotations to define the relation between them. At this point, I have in H2 a table Actor that has ID, AGE, NAME and SURNAME columns, table Movie that has ID, GENRE, TITLE and YEAR, and a new table MOVIE_ACTOR because of the annotation with ACTORS_ID and MOVIES_ID columns. Until here it seems okey. Now, if I save a movie (I have implemented the service and repository extending jpaRepository for both entities): @GetMapping("/create") public void create() { Actor actor1 = new Actor("Pedro", "Perez", "40"); Actor actor2 = new Actor("Alfredo", "Mora", "25"); Actor actor3 = new Actor("Juan", "Martinez", "20"); Actor actor4 = new Actor("Mario", "Arenas", "30"); List<Actor> actorList = new ArrayList<>(); actorList.add(actor1); actorList.add(actor2); actorList.add(actor3); actorList.add(actor4); Movie movie = new Movie("Titanic", "Drama", "1984", actorList); movieService.create(movie); } (I know that it is not a get request, but just for check if a movie is correctly saved just accessing to the endpoint) What I obtain is that in the table Movie the 4 columns are added correctly, but neither ACTOR and MOVIE_ACTOR are completed so actorList is ommited, this two tables are empty. Why this happens and how can I solved it? Thank you so much for your help! A: Maybe you implemented something like this in your service methods (you did not show it) but I would assume that it is missing: You do not cascade anything (respectively save objects of the other class). You should change your @ManyToMany annotation to @ManyToMany(cascade = {CascadeType.PERSIST, CascadeType.MERGE}). This leads to cascading the merge and persist operation (saving a new object or any changes leads to automatically updating the other one). Also consider adding proper add and remove methods for your lists like described in this article and good equals and hashCode methods. In general, you could find very good descriptions of Hibernate related issues on the page of Vlad Mihalcea. Update: Implementation Based on Post of @Alan Hay Model @Entity public class Actor { @Id @GeneratedValue(strategy = GenerationType.IDENTITY) private Long id; private String name; private String surname; private String age; @ManyToMany @JoinTable(name = "movie_actor") private List<Movie> movies = new ArrayList<>(); public void addMovie(Movie movie) { movies.add(movie); movie.getActors().add(this); } public void removeMovie(Movie movie) { movies.remove(movie); movie.getActors().remove(this); } // Constructors, getters and setters... // Equals and hashCode methods a la // https://vladmihalcea.com/how-to-implement-equals-and-hashcode-using-the-jpa-entity-identifier/ } @Entity public class Movie { @Id @GeneratedValue(strategy = GenerationType.IDENTITY) private Long id; private String title; private String genre; private String year; @ManyToMany(mappedBy = "movies", cascade = {CascadeType.PERSIST, CascadeType.MERGE}) private List<Actor> actors; public Movie(String title, String genre, String year, List<Actor> actors) { this.title = title; this.genre = genre; this.year = year; actors.forEach(a -> a.addMovie(this)); } // Getters and setters... } Create Method @GetMapping("/create") public void create() { Actor actor1 = new Actor("Pedro", "Perez", "40"); Actor actor2 = new Actor("Alfredo", "Mora", "25"); Actor actor3 = new Actor("Juan", "Martinez", "20"); Actor actor4 = new Actor("Mario", "Arenas", "30"); List<Actor> actorList = new ArrayList<>(); actorList.add(actor1); actorList.add(actor2); actorList.add(actor3); actorList.add(actor4); Movie movie = new Movie("Titanic", "Drama", "1984", actorList); movieService.create(movie); }

Championdealers proprietary concern, we have evolved to become 'Champion dealers Private Limited', a paramount trader and exporter engaged in Construction Material and Industrial Steels from 1st January 2008. These products are sourced ...

Q: Converting a sum into $\Sigma$ notation I have a simple expression of the form $\quad \quad t^5+t^4+t^3+t^2+t+1$ and I want Mathematica to convert this to the form $\quad \quad \sum _{i=0}^5 t^i$ Is there a way to do this? A: Something like this?: expr = -t^Range[0, 5] // Total toΣ[expr_Plus] := Block[{n}, HoldForm[Sum[#, {n, #2}]] & @@ {FindSequenceFunction[List @@ expr, n], Length@expr}] toΣ@expr If you want to manually set the initial index: toΣ[expr_Plus, init_Integer: 1] := Block[{n, l = Length@expr}, HoldForm[Sum[#, {n, init, #2}]] & @@ {FindSequenceFunction[{Range[init, l - 1 + init], List @@ expr}\[Transpose], n], l}] toΣ[expr, 0]

About Gary Shogren I am a professor of New Testament from the US, working in Costa Rica as a teacher at ESEPA Bible College and Seminary. Soy profesor de Nuevo Testamento, Seminario ESEPA, San José, Costa Rica (http://esepa.org) We are WorldVenture missionaries to Costa Rica. Gary is professor of New Testament at Seminario ESEPA and is a blogger and author. Karen teaches at ESEPA and also specializes in sexual abuse and the church. They have four adult children who live in the USA, and a foster child, Sammy, who lives with them in Costa Rica. Greetings from Lancaster County! First of all: If you use Facebook, please visit us at Shogrens in Costa Rica, and click to follow us for regular updates. Karen writes: We are here in the US until sometime in May for a short home assignment. We have urgent and exciting projects awaiting us in Costa Rica, so we are in a bit more of a hurry than usual to raise the money we need to return: $1850 per month. Visiting Calvary Protestant on Long Island What does that mean? Since we do not take a salary from any of the people we serve, our monthly living expenses all come from donations to our sending board, WorldVenture. We have to raise every penny for all of our expenses: salary, health insurance, Social Security contribution, ministry expenses, etc. Sometimes our donations come from churches, but number-wise, most of them come from individuals. Would you consider becoming one of those individuals who supports us with a regular month gift? If 18 people would sign up to give $100 a month on our behalf, and one would sign up to give $50 a month, we would have reached our goal! You would be a tangible part of Team Shogren, and we would be working side-by-side with you, serving our Lord in Costa Rica. We would love to meet with you personally to share the vision with you! If you would like to share a cup of coffee with us at a shop near your home, please just email Karen to set it up: keshogren@gmail.com Every time we are in the USA, we are reminded that everyone is busy, busy! But there is no excuse for not reading the Bible. Enjoy Gary’s short article, “No Time for Bible Reading?” It is located on openoureyeslord.com, just click here, “No Time for Bible Reading?” Prayer Requests Karen is busy doing research and holding meetings to explore a new ministry Dr. Vikky Shogren has just graduated with her degree from Arcadia in physical therapy and passed her board exams! Financial needs for 2018 You can give us a one-time gift or become a partner through our worldventure.com, click HERE. Let’s label this ministry as: “Hi homeless friend! Would you like some breakfast?” On Saturday, I (Gary) go to the local grocer and buy a kilo of local farmer’s cheese and a couple of loaves of bread and big bottles of iced tea. Then I make up sandwiches for 20 or 25 people, gather paper cups, 2-3 New Testaments in a simplified version, maybe some clothes. On the street around 7am, I leave the car in a parking lot and head out with a jammed-full backpack. I take safety precautions, but since I go out early, most of them are still docile after their Saturday night. The street people migrate from one spot to another, so they aren’t necessarily where I last left them. It takes a second for the brain to register, That pile of rags is a man; that cardboard box is someone’s house. Homeless person in San José, archive photo (NOTE: I used to take a few pictures with people, but now do not; I wonder whether I would be dehumanizing people more than necessary if I took “here- am-being-generous!” selfies) Wherever I see a cluster of people I stop and ask, Would you like some breakfast? I used to ask, “Are you hungry?”, but I switched my phrasing Continue reading → A huge amount of Gary’s teaching and writing has to do with false doctrine. This is an important topic in the USA, but way more so in Latin America. Here is a short article on how the devil not only robs false teachers, but lures them into eternal loss as well. Gary in the Mideast! I (Gary) just got back from a tour along with Oreland Presbyterian, in which we began at Cairo and traced the entire route of the Exodus, through the Sinai, into Jordan, before visiting the main sites in Israel. This was my first time to visit any of these three countries, and I have pictures and memories that will take me months to unravel. At the site of the Temple of Jerusalem If I had to condense the trip down to a few striking places: The “Garden Tomb” – This site might be the tomb where they buried Jesus. But since the evidence for it is very slim, I didn’t think I would enjoy it much. Was I wrong! In fact, the site is owned and run by a group of British Christians Continue reading →

.. include:: ../../common/contacts.rst

Georgia State Route 199 State Route 199 (SR 199) is a state highway in the east-central part of the U.S. state of Georgia. It is a southeast–northwest route through portions of Montgomery, Treutlen, and Laurens counties. It runs from a point north of Mount Vernon northwest to East Dublin. Route description SR 199 begins at an intersection with US 221/SR 56, north of Mount Vernon, in Montgomery County. It heads northwest into Treutlen County, where it intersects SR 46 before meeting SR 199 Spur. Continuing northwest, SR 199 enters Laurens County and travels through rural areas before an interchange with Interstate 16 (I-16), southeast of Dublin. It meets its northern terminus, an intersection with SR 29 in East Dublin. SR 199 is not part of the National Highway System, a system of roadways important to the nation's economy, defense, and mobility. Major intersections Bannered route State Route 199 Spur (SR 199 Spur) is a spur route of SR 199 that exists entirely within the southwestern part of Treutlen County. SR 199 Spur begins in a rural part of the county, at an intersection with Troup Road. It heads northeast and curves to the east and curves back to the northeast. It crosses over Red Bluff Creek before it meets its eastern terminus, an intersection with the SR 199 mainline in Lothair. SR 199 Spur is not part of the National Highway System, a system of roadways important to the nation's economy, defense, and mobility. See also References External links Georgia Roads (Routes 181 - 200) 199 Category:Transportation in Montgomery County, Georgia Category:Transportation in Treutlen County, Georgia Category:Transportation in Laurens County, Georgia

Q: Why a njit function doesn't works when it's inside a class but work when it's outside? I don't understand why the function compute works when it is outside of the the class myclass but doesn't works when it is inside? import numpy as np from numba import njit @njit def compute(length): x=np.zeros(length) for i in range(length): x[i] = i return x class myclass(): def __init__(self): self.length = 100 def Simule(self): res = compute(self.length) print(res) def Simule2(self): res = self.compute(self.length) print(res) @njit def compute(self, length): x = np.zeros(length) for i in range(length): x[i] = i return x if __name__ == "__main__": instance = myclass() instance.Simule() instance.Simule2() A: It seems like this decorator doesn't recognize if a decorated callabe is function or method, you can change it to be a staticmethod: import numpy as np from numba import njit @njit def compute(length): x=np.zeros(length) for i in range(length): x[i] = i return x class myclass(): def __init__(self): self.length = 100 def Simule(self): res = compute(self.length) print(res) def Simule2(self): res = self.compute(self.length) print(res) @staticmethod @njit def compute(length): x = np.zeros(length) for i in range(length): x[i] = i return x if __name__ == "__main__": instance = myclass() instance.Simule() instance.Simule2()

// DO NOT EDIT THIS FILE - it is machine generated -*- c++ -*- #ifndef __gnu_CORBA_GIOP_CancelHeader__ #define __gnu_CORBA_GIOP_CancelHeader__ #pragma interface #include <java/lang/Object.h> extern "Java" { namespace gnu { namespace CORBA { namespace GIOP { class CancelHeader; } } } namespace org { namespace omg { namespace CORBA { namespace portable { class InputStream; class OutputStream; } } } } } class gnu::CORBA::GIOP::CancelHeader : public ::java::lang::Object { public: CancelHeader(); virtual void read(::org::omg::CORBA::portable::InputStream *) = 0; virtual void write(::org::omg::CORBA::portable::OutputStream *) = 0; jint __attribute__((aligned(__alignof__( ::java::lang::Object)))) request_id; static ::java::lang::Class class$; }; #endif // __gnu_CORBA_GIOP_CancelHeader__

Synthesis and carbonic anhydrase inhibitory activity of 4-substituted 2-thiophenesulfonamides. A series of 4-substituted 2-thiophenesulfonamides was prepared from 3-thiophenecarboxaldehyde using metalation chemistry developed for 3-furaldehyde. Several of these compounds inhibit carbonic anhydrase II in vitro at concentrations of less than 10 nM. In addition, none of these compounds exhibit sensitization potential as determined from in vitro measurement of cysteine reactivity.

Instantaneous Shooting This is a simple shooting demo in which the bullets are instantaneous. The target that is being aimed at is hit immediately instead of being able to see where the bullet is going. If you would prefer a demo where you can see the bullet being fired (slower though) visit my other demo at,

Experimental and modeling study of thermal exposure of a self-contained breathing apparatus (SCBA). An experimental apparatus designed to study firefighter safety equipment exposed to a thermal environment was developed. The apparatus consisted of an elevated temperature flow loop with the ability to heat the air stream up to 200°C. The thermal and flow conditions at the test section were characterized using thermocouples and bi-directional probes. The safety equipment examined in this study was a self-contained breathing apparatus (SCBA), including a facepiece and an air cylinder. The SCBA facepiece was placed on a mannequin headform and coupled to a breathing simulator that was programmed with a prescribed breathing pattern. The entire SCBA assembly was placed in the test section of the flow loop for these thermal exposure experiments. Three air stream temperatures, 100°C, 150°C, and 200°C, were used with the average air speed at the test section set at 1.4m/s and thermal exposure durations up to 1200 s. Measurements were made using type-K bare-bead thermocouples located in the mannequin's mouth and on the outer surface of the SCBA cylinder. The experimental results indicated that increasing the thermal exposure severity and duration increased the breathing air temperatures supplied by the SCBA. Temperatures of breathing air from the SCBA cylinder in excess of 60°C were observed over the course of the thermal exposure conditions used in most of the experiments. A mathematical model for transient heat transfer was developed to complement the thermal exposure experimental study. The model took into consideration forced convective heat transfer, quasi-steady heat conduction through the composite layers of the SCBA cylinder wall, the breathing pattern and action of the breathing simulator, and predicted air temperatures from the thermally exposed SCBA cylinder and temperatures at the outer surface of the SCBA cylinder. Model predictions agreed reasonably well with the experimental measurements.

se o = 3*s - 2*o - 42, 1 = o. Suppose -4*v = -3*z + s, 0 = 2*z - 2 - 8. Suppose 2*i - 2 = -v*i. Is 2 greater than i? True Let a = 15.6 + -18. Let k = -2.38 - a. Which is smaller: 2 or k? k Suppose 3*u + 804 = 2061. Which is bigger: 417 or u? u Let z = -25.24 - -25. Let a = 51 - 51.34. Let j = z - a. Is j not equal to 10? True Let k = -138 + 102. Let w be 10*(-9)/15*6. Is w < k? False Let a(p) = -p**2 - 2*p - 1. Let t be a(-2). Let j = t - -2. Let x = 0.042 + 1.958. Which is bigger: x or j? x Let m(j) = -2*j**2 + j - 1. Let w be m(1). Let f(b) = -15*b - 33. Let l be f(-3). Let s be (l/21)/((-8)/28). Is s equal to w? True Let s = -210 + 303. Which is bigger: 3/7 or s? s Let z be (-411)/(-12) - 1/4. Let l = -21 + z. Is 13 less than or equal to l? True Let d = -882 + 6164/7. Suppose 2*y + 3*i - 10 = 0, -2*y - 5*i = 2*y - 18. Suppose y*x - x = -2. Which is bigger: x or d? d Let o = -57.7 + 57.85. Which is bigger: o or 4/3? 4/3 Let n(a) = a**3 + 4*a**2 + a + 4. Let d be n(-4). Suppose 2*g + 43 = -5*x + 40, 5*g = -5*x. Which is greater: d or g? g Let x(q) be the third derivative of q**5/60 - 3*q**4/8 + 5*q**3/6 - 3*q**2. Let w be x(6). Let r be 4/10 + w/45. Are r and 0 nonequal? True Let l be ((-3644)/(-15))/(-4) + (-8)/(-20). Is l less than or equal to 1? True Suppose -47*v - 1680 = -12*v. Let i = 119 + -167. Is i less than or equal to v? True Let s be (5/10)/((-2)/(-752)). Is s equal to 189? False Let t = 28 + -30. Let s be ((-10)/(-4)*t)/(10 + 1). Do s and -1 have the same value? False Let k = 4.5 - 5. Let p = -0.5 - k. Let s = 0.139 + -4.139. Which is smaller: p or s? s Suppose 5*a = -2 - 3. Let k be ((-9672)/325)/(-78 - -1). Let r = 4/175 - k. Is a less than or equal to r? True Let j = -347/18 + 41/2. Is j at least 0? True Suppose 58 = 3*d + 3*w + w, -4*d + 2*w = -48. Are 15 and d unequal? True Let j(b) = -2*b**3 + 3*b**2 + b - 19. Let u be j(-3). Suppose 0 = 2*f - 6*f + 240. Which is bigger: f or u? f Let v be 28934/506 - (-2)/(-11). Is 46 at least as big as v? False Let j be ((-172)/16)/(1/(-4)). Suppose 2*k + j + 61 = 0. Let l = k - -35. Which is smaller: -18 or l? -18 Let f = 168 - 242.08. Let t = -74 - f. Which is smaller: t or -4/9? -4/9 Let s(b) = -b**3 + b + 1. Let x(y) = -2*y**3 - 2*y**2 + 3*y - 5. Let v(j) = -3*s(j) + x(j). Let g be v(4). Which is greater: 25 or g? 25 Let h = -1428 + 1430. Is h at most as big as 48/47? False Suppose -4*k = -3*d + 4, 0 = -4*d - 2*k - 27 + 3. Which is greater: 56 or d? 56 Let d = -42 + 169/4. Suppose 6*h = 14*h + 224. Let i be 1/(-4) - 14/h. Is i at least as big as d? True Let g be (-1)/3*0 - -2. Suppose -1 = 2*a + 3*a - 2*d, 17 = g*a + 5*d. Which is bigger: a or -6/13? a Let t = 144.7 - 144.2. Does 2 = t? False Let p = -6 + 12. Let a = p + -5.9. Which is smaller: 0.27 or a? a Let z = -9128/23 - -397. Is z at most as big as 1/5? True Let d = -41 - -38. Let k be (-6 - -6) + d/(-3). Which is bigger: 1/129 or k? k Let n be ((-3)/3)/((-2)/18*1). Let a(c) = -c**2 + 8*c + 7. Let u be a(n). Let z = 1 - 2. Which is smaller: u or z? u Suppose f - 96 + 1 = -t, 10 = 2*t. Is 91 equal to f? False Let s = 374 + -374. Which is greater: -3/47 or s? s Let b(n) be the second derivative of -n**3 - n**2/2 - n. Let u be b(-1). Let k = -3292 + 3297. Is k smaller than u? False Let s(v) = v**3 + 3*v**2 + v + 3. Let i be s(-3). Suppose -b = -3*z - 1, 5*z + 15 = 6*b - b. Let l be (122/(-130) + z)*(-4)/8. Are l and i nonequal? True Suppose 3*h + 2*d + 19 = -0*d, -d = -2*h - 8. Let k be 3/(-3) + 5*(-2)/h. Do 2/197 and k have the same value? False Let b be 2/6 + (-12160)/36840. Which is bigger: -1 or b? b Suppose -3*p + 4*p + 4 = 0. Let y = 990 + -993. Which is greater: p or y? y Let x be 1/3*(-13 + 16). Let m(f) = -3*f**2. Let z be m(x). Let o be ((-3)/2)/(z/(-6)). Do o and -0.6 have different values? True Suppose -5 = 3*c - 0*w + w, 3 = -c + w. Let z(h) = h**2 - 5*h - 16. Let i be z(8). Let u(l) = l - 9. Let a be u(i). Does a = c? False Let k = 33 + -60. Let f = k + 19. Suppose 6*n - 2*n = -32. Is f < n? False Let z = 14 + -24. Let a be z*(4 + 66/(-15)). Suppose 5*n - 26 = a*o, -3*o - 5*n = -4*o - 14. Is o != -4? False Let y(m) = -5*m + 37. Let v be y(7). Let b be 0 - v/(-8) - 8/32. Is 0.01 != b? True Let u be 508/(-1232)*2/2. Let n = u + -7/44. Suppose -84 + 92 = -4*v. Which is smaller: n or v? v Let v = 0.047 - 0.014. Let u = v - -0.014. Do u and 1/3 have the same value? False Let f = -1.2 - -1.2. Let r = f + -3. Let h = r + 3. Is -1/9 > h? False Let s = 2565 - 2547. Which is bigger: s or -14? s Let t = 29/3 - 37/6. Is -8 at least as big as t? False Suppose 0 = 2*h + 3*h - 20. Let r = -0.2 + 0.5. Let k = 3.3 - r. Which is bigger: h or k? h Let a = -883 + 885. Is a less than 2/5? False Suppose -10*s = -4 + 4. Which is smaller: s or 26/27? s Let i(d) = 5*d**2 + 4*d + 1. Let n be i(-4). Suppose 4*u - 4*k + 3*k = 267, 3*k + 9 = 0. Is u != n? True Let z = 7.939 + 1.061. Is -7 > z? False Let j = 94.8 + -113. Does j = 0.1? False Let m = 337 - 337. Let k = 0.01 + 0.07. Is k > m? True Let x be (-3)/(-2) + (-2)/(-4)*-1. Let a be ((-1)/(-2))/((-4)/148*x). Are a and -18 equal? False Suppose -2*p + 4 = 0, -2*p = 3*g + g - 260. Let l be -1 + 18/g*4. Are l and 0 nonequal? True Suppose -24 = -4*g - 2*j, 5*j = -44*g + 46*g - 24. Do g and -19 have different values? True Let r be 3*(-1)/((-18)/48). Is r less than 7? False Let d = -2.686 + -0.014. Let v = 11.6 + -9. Let i = v + d. Is i >= -1? True Suppose -3*g - 1 = -4*f + 2, -2*f = -6. Suppose -2*m - g*m = 50. Let b be (-3)/m*8/(-24). Which is greater: b or 1? 1 Let t = -126 - -129. Which is smaller: t or -45? -45 Suppose -8*v + 9*v = 0. Suppose 2*k - 5*f = -2*k - 5, 3*k + 3*f = 3. Let i be (k - v) + (-10)/(-35). Which is smaller: 1 or i? i Let k = -113337172/15 + 7550676. Let s = k - -16036/3. Let n = 210 - s. Which is greater: 1 or n? 1 Suppose 0 = -4*h - 12, -10*h + 9 = a - 13*h. Is a at most 25/51? True Suppose 7*k = -2*k. Which is smaller: -56/65 or k? -56/65 Suppose 24 = 110*b - 122*b. Let f be 2*(-2)/4 - 3. Is b >= f? True Let m = 607 - 575. Which is smaller: m or -2/9? -2/9 Let r = 4793/5 + -953. Suppose 105 = 5*s - 165. Let v be s/8 + 9/(-12). Is v at least r? True Let m(s) = 7*s - 9. Let t be m(5). Let n be ((-1)/t)/((-4)/16). Is -1 bigger than n? False Let k be (-5892)/(-36) + 1/3. Is 164 greater than or equal to k? True Suppose 5 = -d - 4*d. Let a be (114/111)/(-5 + 17). Let f = -3/37 - a. Is d greater than f? False Let o be (-2)/((-36)/482) - (3 - (-116)/(-36)). Let d(k) = 2*k**2 - k - 2. Let g be d(4). Which is smaller: g or o? g Let v = -397149/13 + 30509. Which is bigger: -42 or v? v Let d be (8/(-20))/((-3)/105). Is d at most 13? False Let b = 0.2 - 1.8. Let y = -0.051 - 0.049. Is y bigger than b? True Let t = -17 + 29.5. Let x = 8.2 - t. Which is greater: x or -0.1? -0.1 Suppose -3*t = -15 + 3. Let k be (-22)/(-152) - t/16. Which is bigger: 0 or k? 0 Let q = -2.3 + 92. Let y = -90 + q. Which is bigger: y or -0.1? -0.1 Let n = -263/3 + 20783/237. Which is smaller: -13 or n? -13 Let c(s) = -92*s + 271. Let m be c(5). Is -184 > m? True Let t = -75.9 - -78.9. Which is greater: -78/11 or t? t Let i = -58 - -23. Let r be (-32)/6*6 - 3. Is i > r? False Let b = -38 + 79/2. Let j be (-150)/(-138) - 32/368. Is b greater than j? True Let v = 406.3 + -406. Is -50 <= v? True Let u = -32.3 + 31. Let f = u + 0.3. Let v be (33/6 - 3)*28/10. Which is bigger: f or v? v Suppose 2*o + 5*h = 374, -25 = -o + 4*h + 149. Does o = 181? False Suppose 89*w + 5508 = 106*w. Which is bigger: w or 326? 326 Suppose 0 = -k - 5*a + 1 + 12, 4*k = 3*a - 17. Let m be (-143)/(-77) - (-2 - (5 - 10)). Which is smaller: k or m? k Suppose 0 = -5*j + 5*a + 190 - 1545, 0 = -4*j - a - 1069. Which is smaller: -267 or j? j Let u = 83 - -92. Suppose 4*j + 149 = 2*h + 9, -h + u = -5*j. Let q = 22 + j. Is -13 equal to q? True Let f(o) = -5*o + 1. Let w be f(1). Let i be (-3)/42 - (-2)/w. Let r = 74 - 74. Is r greater than i? True Let g = -0.413 + -0.017. Let q = -172 + 171.8. Is q less than g? False Let m be (-1 - 2/2)*4/8. Is -2/237 bigger than m? True Let a(t) = 15*t + 182. Let z be a(-19). Is -102 < z? False Let i = 324 + -154. Let p be 1*20*(-4)/i. Is 1 greater than p? True Let f be 21/(-1638)*-12 - 6051/39416. Is -1 sm

You may want to implement role-based security, where you only allow users assigned a certain role to perform certain actions in an application. Many different classes in your code will need role-based security added to them. As it turns out, role-based security is a cross-cutting concern. Well, Aspect Oriented Programming (AOP) can help you modular such a role-based security structure. Lets start with an example. Maybe you have a database filled with people (people being a list of user or person objects). You want to control the list of people. Now think of the Create, Read, Update, Delete (CRUD) pattern. Now turn those into four permissions. Any role could potentially have or not have rights to create a person, read a person’s info, update a person’s info, or delete a person. An admin user would likely have all of the four CRUD rights. A user would likely have CRUD rights for their own user, but just read rights for other users. Your design might have multiple levels of rights as well. You may want to provide multiple levels of read permissions. Think of any social network where you have more read rights if you are a friend of another Person. If it was just for a Person object, you probably would implement an AOP-based solution. However, a large application will have dozens of classes around the Person class. It will have many entities besides Person and those entities have many surrounding data classes as well. What if you had to add code to over 100 class objects? Now you can really benefit from an AOP-based design. Well, I am going to show you example to help get you started. Lets say you want to encrypt a field of a class. You might think that this is not a crosscutting concern, but it is. What if throughout and entire solution you need to encrypt random fields in many of your classes. Adding encryption to each of the classes can be a significant burden and breaks the “single responsibility principle” by having many classes implementing encryption. Of course, a static method or a single might be used to help, but even with that, code is must be added to each class. With Aspect Oriented Programming, this encryption could happen in one Aspect file, and be nice and modular. Prereqs This example assumes you have a development environment installed with at least the following: JDK AspectJ Eclipse (Netbeans would work too) Step 1 – Create an AspectJ project In Eclipse, choose File | New | Project. Select AspectJ | AspectJ Project. Click Next. Name your project. Note: I named my project AOPRolePermissions Click Finish. The project is now created. Step 2 – Create a class containing main() Right-click on the project in Package Explorer and choose New | Class. Provide a package name. Note: I named my package the same as the project name. Give the class a name. Note: I often name my class Main. Check the box to include a public static void main(String[] args) method. You are done. Go ahead and run the program. You should get the following output. Checking permissions... Success: Role has permissions to Update field named AOPRolePermissions.Person.FirstName. Checking permissions... Success: Role has permissions to Update field named AOPRolePermissions.Person.LastName. Checking permissions... Success: Role has permissions to Read field named AOPRolePermissions.Person.FirstName. John Checking permissions... Success: Role has permissions to Read field named AOPRolePermissions.Person.LastName. Johnson Checking permissions... Failure: Role has insufficient permissions to Update field named AOPRolePermissions.Person.FirstName. Checking permissions... Failure: Role has insufficient permissions to Update field named AOPRolePermissions.Person.LastName. Checking permissions... Success: Role has permissions to Read field named AOPRolePermissions.Person.FirstName. John Checking permissions... Success: Role has permissions to Read field named AOPRolePermissions.Person.LastName. Johnson My other blogs Entries (RSS) and Comments (RSS). Copyright ® Rhyous.com Linking to content on this site is allowed without permission and as many as ten lines of any article can be used along with such link. Any other use of the content is allowed only by permission of Rhyous.com.

Wargaming at Arsenalen – What to expect! On 26 November we are inviting all of you to join us in Strängnäs, Sweden at the Arsenalen tank museum for the official opening of a new permanent World of Tanks gaming zone in the museum! Alongside the museum’s excellent collection of tanks and various tracked vehicles, there will be a variety of activities to take part in to make your day out at Arsenalen truly memorable! Please keep in mind that museum admission charges still apply, and for more information you can check out the museum website. Goodies! Pick up one of 2,000 limited edition Arsenalen World of Tanks t-shirts along with a neat goodie bag, a bonus code, and one item of World of Tanks memorabilia (while supplies last). Activities! When: 10:00 - 15:30 CET Participate in our walking quiz (Tipsrunda), kindly organised by the awesome [MOOSE] clan! If you are able to answer all the questions correctly, you may win one of 25 Swedish Strv m/42-57 Alt A.2Premium tanks or one of3 HyperX Predator 250GB SSDs. When: 11:00 - 15:00 CET Play one game at the [MOOSE] clan gaming station and get as much base experience as possible! The best 20 tankers will be rewarded with a prize at 15:30. When:12:30 and 16:30 CET Take a picture of yourself or your clan mates at the museum and tweet it with the following hashtag, #Arsenalen! We will pick 10 tweets twice during the event to win a VIP bonus code – watch your Twitter and collect your prize at the goodie-bag stand if you win! Famous Tankers! A tank event would not be complete without some famous tankers, both virtual and real-life, to talk to! Meet our community contributors The Mighty Jingles, Circonflexes and SirFoch, as well as pro eSports player Yzne from Kazna Kru. If you look hard enough, you will also find The Challenger mingling with the crowd! Swedish Tanks! When:12:00, 14:00, and 16:30 CET We will be holding a presentation on the development and research of the upcoming Swedish Tech Tree. Learn about the tanks’ backgrounds and some of the challenges we faced when implementing these unique vehicles.

PRAXES to support Clipper Round the World Race PRAXES Medical Group has signed on as the Global Medical Emergency Support Partner for the Clipper Round the World Yacht Race to provide global medical emergency coverage for Clipper Race crew. Based in Halifax, Nova Scotia, Canada, PRAXES will provide the Clipper Race with their 24-hour EMdoc service which gives immediate access to physicians who are trained in emergency medicine while their EMwerx software will track the medical information for all participating Clipper Race crew and skippers, allowing specialist care to be delivered during an emergency situation. PRAXES CEO Susan Helliwell said: “We are delighted to be partners with the Clipper Round the World Race. Both of our organizations are focused on reducing risk at sea. Our EMdoc service will be on call and ready to respond to crew and skipper24/7.” In the event of an incident on board during the Clipper Race, the skipper will be able to call PRAXES for medical advice. The on call physician will have access to the crew members’ medical history to be able to diagnose remotely and recommend appropriate treatment. PRAXES physicians are all highly trained specialists in remote triage, who regularly give telephone advice to naval vessels, oil rigs, air transport programmes, poison information centres and other health professionals in a variety of remote settings. As well as providing peace of mind for crew and their loved ones, it is expected the service will significantly reduce the number of in-port hospital visits and medevac situations during the race. Sir Robin Knox-Johnston, Chairman and Founder of the Clipper Race said: “The Clipper Race crew will take on the most dangerous oceans in the world during their adventure and their safety is always our prime concern. Having PRAXES’ support during the race will give reassurance to the crew and their loved ones that, should anything happen during the race they will have access to the best medical care.” Nova Scotia native Jim Cole, a crew member on board New York, suffered an injury during the Clipper 11-12 Race. The 73-year-old from Halifax said: “Had this service been available during the Clipper 11-12 Race, it could have been very helpful when I managed to break a finger on the North Atlantic crossing from Halifax to Ireland. The doctor who had been on board, had to leave earlier in New York for medical reasons, so we were more or less left to our own devices in terms of dealing with the injury. No question, the PRAXES service could have played a very valuable role had it been available.” All Clipper Race crew will be given the opportunity to upload their medical histories to EMwerx prior to the start of the race where it will be kept confidentially in case of emergency. NOTES TO EDITORS For further information on the Clipper Race please visit www.clipperroundtheworld.com For media information or interview requests please contact: Marina Thomas, PR Manager Email: email hidden; JavaScript is required For further information on PRAXES visit www.praxes.ca or for interview requests please contact : About PRAXES Medical Group PRAXES has been supporting remote workers in dangerous environments since 1997. Its global Telemedicine service is Canada’s premiere telemedicine service for industry. It also supplies a range of medical services from medical exams to the set up and operation of remote medical clinics. The PRAXES mission is to improve remote health care while simultaneously reducing cost and risk for clients. About Clipper Ventures Plc Clipper Ventures Plc was established in 1995 by legendary yachtsman Sir Robin Knox-Johnston, the first person to sail solo non-stop around the world in 1968-69. Sir Robin founded the company on the premise that sailing should be made available to everyone, regardless of age or experience. So he launched the Clipper Round the World Yacht Race in 1996. The company owns and operates its own matched fleet of ocean racing yachts and so far more than 3,000 people have competed in the eight editions of the Clipper Race to date. The company also owns the rights to the professional solo round the world VELUX 5 OCEANS race and runs a successful events division offering corporate sailing and development programmes. Today Clipper Ventures is recognised as a leading international marine events company which is focused on developing and promoting major global events such as the Clipper Race. Clipper 13-14 Round the World Yacht Race The Clipper 13-14 Round the World Yacht Race will start in summer (UK) 2013 and return almost a year later after completing the 40,000 miles route, making it the world’s longest ocean race. The event was established by Sir Robin Knox-Johnston to give everyone, regardless of sailing experience, the opportunity to discover the exhilaration of ocean racing. 650 people representing more than 40 nations will compete in the Clipper 13-14 Race on twelve brand new 70-foot yachts designed by renowned naval architect Tony Castro. It’s the largest race ever. Crew members can sign up for the whole circumnavigation or one or more of eight legs. The only qualification for the race is the minimum age of 18 (there is no upper age limit) plus a thirst for adventure. The overall race is divided into individual stages and points are accumulated in a Formula 1-style scoring system. The yacht with the highest total points at the finish wins the Clipper Trophy. Sir Robin Knox-Johnston It’s nearly 45 years since Sir Robin Knox-Johnston set off on his record breaking solo and non-stop circumnavigation in 1968-69. Now, as Executive Chairman and founding Director of Clipper Ventures Plc, he is at the forefront of promoting round the world yacht racing. Sir Robin has been involved in sailing all his life and holds a Department of Transport Master’s Certificate. He set the record for the fastest circumnavigation with Sir Peter Blake. In 2007; he completed his second solo circumnavigation when he competed in the VELUX 5 OCEANS race. Sir Robin has considerable experience of the administration of round the world races having served on the Whitbread Race committee from 1990 to 1994 and having organised the BOC Challenge Round the World Race in 1982 and 1986. He has been named RYA/YJA Yachtsman of the Year an unprecedented three times and participated in the 2010 Sydney-Hobart race at the age of 71.

[Homografts of irradiated costal cartilage]. Preserved irradiated homologous rib cartilage are not frequently used in spite of many publications confirming its value. A review of 62 cases with at least two years follow-up is presented confirming the absence of resorbtion or immunology response. Further more preserved irradiated rib cartilage has been used as replacement for bone grafts in a serie presented with illustrations of the stable results obtained. The change of behavior of homologous cartilage in human introduced by gamma irradiation would need to be investigated.

--- abstract: 'The Higgs inflation scenario is an approach to realize the inflation, in which the Higgs boson plays a role of the inflaton without introducing a new particle. We investigate a Higgs inflation scenario in the so-called radiative seesaw model proposed by E. Ma. We find that a part of parameter regions where additional scalar fields can play a role of an inflaton is compatible with the current LHC results, the current data from neutrino experiments and those of the dark matter abundance as well as the direct search. We show that we can partially test this model by measuring masses of scalar bosons at the International Linear Collider.' author: - Toshinori Matsui title: 'Testability of the Higgs inflation scenario in a radiative seesaw model [^1] ' --- Introduction ============ In 2012, the LHC discovered a new particle with the mass of 126 GeV [@atlas; @cms]. The particle is regarded as the Higgs boson predicted in the Standard Model (SM) of elementary particles. The discovery of the Higgs boson means that all the particle contents in the SM are completed. The LHC is now searching for indications of new physics, and is trying to measure the deviation in the coupling from the SM. On the other hand, the cosmic observations such as the experiments at WMAP and Planck have reported the new results [@WMAP; @Planck]. These experiments measure the temperature fluctuation of the cosmic microwave background precisely, by which we can impose constraints on the models of inflation. Cosmic inflation at the early Universe [@inf], which is a promising candidate to solve cosmological problems such as the horizon problem and the flatness problem, requires an additional scalar boson, the inflaton. We consider the Higgs inflation scenario where the Higgs boson plays a role of the inflaton. In the minimal model of this scenario [@Hinf], we do not have to introduce any other particle in addition to the particle contents in the SM to explain an inflation. However, it would be difficult to realize the Higgs inflation scenario in the minimal model. Assuming the SM with one Higgs doublet, the vacuum stability argument indicates that the model can be well defined only below the energy scale where the running coupling of the Higgs self-coupling becomes zero. For the Higgs boson mass to be 126 GeV with the top quark mass to be 173.1 GeV and for the coupling for the strong force to be $\alpha_s =$ 0.1184, the critical energy scale is estimated to be around $10^{10}$ GeV using the NNLO calculation, although the uncertainty due to the values of the top quark mass and $\alpha_s$ is not small [@lambda_run]. The vacuum seems to be metastable when we assume that the model holds up to the Planck scale. This kind of analysis gives a strong constraint on the scenario of the Higgs inflation, because the inflation occurs at the energy scale where the vacuum stability is not guaranteed in the SM. Recently, a viable model for the Higgs inflation has been proposed, in which the Higgs sector is extended including an additional scalar field [@other_Hinf; @2Hinf]. There is also another problem in the minimal model, which comes from unitarity argument [@uni_break; @uni_care]. Extending the Higgs sector from the SM one, we may expect to reveal new physics that can explain phenomena such as neutrino oscillation, existence of dark matter and baryon asymmetry of the Universe. Here, we extend the Higgs inflation model in the framework of a radiative seesaw scenario by E. Ma [@Kanemura:2012ha]. The radiative seesaw scenario is a way to explain tiny neutrino masses, where they are radiatively induced at the loop level by introducing $Z_2$-odd scalar fields and $Z_2$-odd right-handed neutrinos [@KNT; @Ma; @AKS]. An interesting characteristic feature in these radiative seesaw models is that dark matter candidates automatically enter into the model because of the $Z_2$ parity. In this work, we discuss a simple model to explain inflation, neutrino masses and dark matter simultaneously, which is based on the simplest radiative seesaw model [@Ma]. Both the Higgs boson and neutral components of the $Z_2$-odd scalar doublet can satisfy conditions on the slow-roll inflation [@slow-roll] and vacuum stability up to the inflation scale. We find that a part of the parameter region where these scalar fields can play a role of the inflaton is compatible with the current LHC results, the current data from neutrino experiments and those of the dark matter abundance as well as the direct search [@XENON100]. A phenomenological consequence of scenario results in a specific mass spectrum of scalar fields, which can be tested at the International Linear Collider (ILC) [@ILC1]. Extension to a radiative seesaw model ===================================== We extend the Higgs inflation model in the framework of a radiative seesaw scenario [@Ma]. In this model, there are the $Z_2$-odd scalar doublet field $\Phi_2$ and right-handed neutrino $\nu_R^{}$ in addition to the $Z_2$-even SM Higgs doublet field $\Phi_1$ due to the invariance under the unbroken discrete $Z_2$ symmetry [@Ma]. Because Dirac Yukawa couplings of neutrinos are forbidden by the $Z_2$ symmetry, the Yukawa interaction for leptons is given by ${\cal L}_{Yukawa} = Y_\ell \overline{L_L}\Phi_1\ell_R+Y_\nu\overline{L_L}\Phi_2^c\nu_R+h.c.$ (the superscript $c$ denotes the charge conjugation). The scalar potential is given by [@2Hinf] $$\begin{aligned} V &=&\frac{M_P^2 R}{2}+(\xi_1|\Phi_1|^2 +\xi_2 |\Phi_2|^2)R +\mu_1^2 |\Phi_1|^2 + \mu_2^2 |\Phi_2|^2 \nonumber\\ &&+ \frac{1}{2} \lambda_1 |\Phi_1|^4 + \frac{1}{2} \lambda_2 |\Phi_2|^4 + \lambda_3|\Phi_1|^2|\Phi_2|^2 + \lambda_4 (\Phi_1^{\dagger} \Phi_2) (\Phi_2^{\dagger} \Phi_1) + \frac{1}{2}\lambda_5((\Phi_1^{\dagger} \Phi_2)^2+h.c.), \label{eq:potential}\end{aligned}$$ where $M_P$($\simeq 10^{19}$ GeV) is the Planck scale, and $R$ is the Ricci scalar. Then, these quartic coupling constants should satisfy the following constraints on the unbounded-from-below conditions at the tree level; $$\begin{aligned} \lambda_1>0,\ \ \lambda_2>0,\ \ \lambda_3+\lambda_4+\lambda_5+\sqrt{\lambda_1 \lambda_2}>0, \label{eq:vs}\end{aligned}$$ and we impose the conditions of triviality; $$\begin{aligned} \lambda_i \lesssim 2\pi. \label{eq:tri}\end{aligned}$$ Assuming $\mu_1^2 < $0 and $\mu_2^2 >$ 0, $\Phi_1$ obtains the vacuum expectation value (VEV) $v$ ($=\sqrt{-2\mu_1^2/\lambda_1}$), while $\Phi_2$ cannot get the VEV because of the unbroken $Z_2$ symmetry. The lightest $Z_2$-odd particle is stabilized by the $Z_2$ parity, and it can act as the dark matter as long as it is electrically neutral. Mass eigenstates of the scalar bosons are the SM-like $Z_2$-even Higgs scalar boson ($h$), the $Z_2$-odd CP-even scalar boson ($H$), the $Z_2$-odd CP-odd scalar boson ($A$) and $Z_2$-odd charged scalar bosons ($H^\pm$). Masses of these scalar bosons are given by [@Ma]; $m_h^2=\lambda_1 v^2, \ m_H^2=\mu_2^2 +\frac{1}{2}(\lambda_3+\lambda_4+\lambda_5) v^2, \ m_A^2=\mu_2^2 +\frac{1}{2}(\lambda_3+\lambda_4-\lambda_5) v^2, \ m_{H^{\pm}}^2=\mu_2^2 +\frac{1}{2}\lambda_3 v^2$. Constraints on the parameters ============================= For the Higgs inflation scenario in our model defined in the previous section, there are nine parameters in the scalar sector; i.e., $\xi_1$, $\xi_2$, $\mu_1^2$, $\mu_2^2$, $\lambda_1$, $\lambda_2$, $\lambda_3$, $\lambda_4$ and $\lambda_5$. They must satisfy the vacuum stability condition on the running of the scalar coupling constants and the constraint from the slow-roll inflation, the dark matter data and the neutrino data. We find that a part of parameter regions is compatible with all constraints. Then, we can get the possible mass spectrum for additional scalar bosons in our model [@Kanemura:2012ha]. First, we discuss the constraint from the slow-roll inflation. In order that some of the scalar bosons play a role of the inflaton, we need to impose following conditions [@2Hinf]; $$\begin{aligned} \lambda_2\xi_1-(\lambda_3+\lambda_4)\xi_2&>&0, \nonumber\\ \lambda_1\xi_2-(\lambda_3+\lambda_4)\xi_1&>&0, \nonumber\\ \lambda_1\lambda_2-(\lambda_3+\lambda_4)^2&>&0. \label{eq:vs2}\end{aligned}$$ Parameters in the scalar potential should satisfy the constraint from the power spectrum [@WMAP; @2Hinf]; $$\begin{aligned} \xi_2 \sqrt{\frac{2(\lambda_1+a^2\lambda_2-2a(\lambda_3+\lambda_4))}{\lambda_1\lambda_2-(\lambda_3+\lambda_4)^2}} \simeq 5\times 10^{4}, \ \ \ \ \ \frac{\lambda_5}{\xi_2} \frac{a\lambda_2 - (\lambda_3+\lambda_4)}{\lambda_1+a^2\lambda_2-2a(\lambda_3+\lambda_4)} \lesssim 4\times 10^{-12}, \label{eq:l5}\end{aligned}$$ where $a$ is given as $a\equiv\xi_1/\xi_2$. When the scalar potential satisfies the conditions in Eqs. (\[eq:vs2\]) and (\[eq:l5\]), the model could realize the inflation. Second, we discuss the constraint from dark matter. We here assume that the CP-odd boson $A$ is the dark matter (the lightest $Z_2$-odd particle). When $\lambda_5$ is very small such as ${\cal O}(10^{-7})$, $A$ is difficult to act as the dark matter because the scattering process $AN\to HN$ ($N$ is a nucleon) opens and the cross section cannot be consistent with the current direct search results for dark matter [@direct_Z; @Kashiwase:2012xd; @LopezHonorez:2006gr]. To avoid the process $AN\to HN$ kinematically, we here take $\lambda_5\simeq 10^{-6}$ and $$\begin{aligned} a\lambda_2 - (\lambda_3+\lambda_4)\simeq 10^{-1} \label{eq:FT}\end{aligned}$$ at the inflation scale. With this choice, masses of $A$ and $H$ are almost the same value. The co-annihilation process $AH\to XX$ via the $Z$ boson is important to explain the abundance of the dark matter where $X$ is a particle in the SM, because the pair annihilation process $AA\to XX$ via the $h$ boson is suppressed due to the constraint from the inflation. Because the cross section of $AH\to XX$ depends only on the mass of the dark matter, the mass of the dark matter $A$ is constrained from the abundance of the dark matter as $128~{\rm GeV}\leq m_A\leq138~{\rm GeV}$, where we have used the nine years WMAP data [@WMAP]. Third, we can explain tiny neutrino masses in this model which are generated by the one loop diagram [@Ma]. The neutrino mass is related to $\lambda_5$ and masses of scalar bosons ($m_H^{}$ and $m_A^{}$), which are constrained from the inflation and the dark matter. From the relation $(Y_\nu)_i^k(Y_\nu)_j^k/M_R^k\simeq {\cal O} (10^{-11})$ GeV$^{-1}$ where $M_R^k$ is the Majorana mass of $\nu_R^k$ ($k$=1-3) and $(Y_\nu)_i^k$ is neutrino Yukawa coupling constant, the magnitude of tiny neutrino masses can be explained. For example, when $M_R^k$ is ${\cal O}(1)$ TeV, $(Y_\nu)_i^k$ is ${\cal O}(10^{-2})$. captype[table]{} $\lambda_{1}$ $\lambda_{2}$ $\lambda_{3}$ $\lambda_{4}$ $\lambda_{5}$ --------------- --------------- --------------- --------------- --------------- -------------------- $10^{2}$ GeV 0.26 0.35 0.51 -0.51 1.0$\times10^{-6}$ $10^{17}$ GeV 1.6 6.3 6.3 -3.2 1.2$\times10^{-6}$ Finally, we calculate the running of the coupling constants using the renormalization group equations [@beta]. As shown in Fig \[fig:run\], for the contribution of additional scalar bosons, this model can be stable up to the inflation scale from the electroweak scale [@extended_run]. As numerical input parameters, we take the VEV ($v = 246~$GeV), SM-like Higgs mass ($m_h = 126$ GeV) and the allowed value for the dark matter mass ($m_A^{} = 130$ GeV). Further numerical input parameter comes from the perturbativity of $\lambda_2$ up to the inflation scale; i.e., $\lambda_2(\mu_{\rm inf}) = 2\pi$, where $\mu_{\rm inf}$ is the inflation scale $10^{17}$ GeV. The parameter set in Table \[table:lambda\] can be consistent with these numerical inputs and the constraints are given in Eqs. (\[eq:vs\])-(\[eq:FT\]). Consequently, we can obtain the mass spectrum of the scalar bosons in our model as $$\begin{aligned} m_h\simeq126~{\rm GeV}, \ \ \ m_{H^{\pm}}\simeq173~{\rm GeV},\ \ \ m_H\simeq130~{\rm GeV},\ \ \ m_A\simeq130~{\rm GeV}, \label{eq:hmassD}\end{aligned}$$ where the mass difference between $A$ and $H$ is about 500 KeV. The mass spectrum is not largely changed even if $m_A^{}$ is varied with in its allowed region. In the next section, we consider the constraints on our model from the existing experiments and the way to test the characteristic mass spectrum in this model at the future collider experiment. Phenomenology ============= The LEP experiment constrains masses of the $Z_2$-odd scalar bosons. The mass of charged scalar bosons $m_{H^\pm}^{}$ should be lager than 70-90 GeV by the LEP [@LEP_direct; @LEP_pm]. This constraint is satisfied in our model ($m_{H^{\pm}}\simeq173~{\rm GeV}$). Furthermore, $m_{H}^{} + m_{A}^{}$ should be larger than $m_Z^{}$, and the combination of $m_{H}^{}$ and $m_{A}^{}$ is bounded by $H$$A$ production by the LEP date [@LEP_direct; @LEP_HApair]. However, when $m_{H}^{} - m_{A}^{} < 8$ GeV, masses of neutral $Z_2$-odd scalar boson loop diagrams are not really constrained by the LEP [@LEP_direct; @LEP_HApair]. On the other hand, the contributions to the electroweak parameters [@STdef] from additional scalar bosons loops which are given by [@ST1; @ST2] are also consistent with the electroweak precision data with 90% Confidence Level (C.L.) [@ST2]. Next, we consider the way to test at the LHC. According to Refs. [@LHC1; @LHC2; @LHC3], they conclude that it could be difficult to test $pp\to AH^+/HH^+/H^+H^-$ processes because the cross sections of the background processes are very large. The process of $pp\to AH$ could be tested with about the 3$\sigma$ C.L. with the various benchmark points for $m_A$ and $m_H$. However, it would be difficult to test $pp\to AH$ in our scenario, because $m_H$ and $m_A$ are almost degenerate in our scenario, and the event number of $pp\to AH$ is negligibly small after imposing the basic cuts [@LHC1; @LHC2; @LHC3]. Furthermore, as the total decay width of $H$ is about $10^{-29}$ GeV, $H$ would pass through the detector. Therefore, this signal is also difficult to be detected at the LHC. Finally, we discuss the signals of $H, A$ and $H^\pm$ at the ILC with $\sqrt{s}=500$ GeV. In the following, we use Calchep 2.5.6 for numerical evaluation [@calc]. We focus on the $H^\pm$ pair production process: $e^+e^-\to Z^*(\gamma^*)\to H^+H^-\to W^{+(*)}W^{-(*)}AA\to jj\ell\nu AA$ ($j$ denotes a hadron jet) [@ILC2]. Because of the kinematical reason, the energy of the two-jet system $E_{jj}$ satisfies the following equation; $$\begin{aligned} \frac{m_{H^{\pm}}^2-m_A^2}{\sqrt{s}+2\sqrt{s/4-m_{H^{\pm}}^2}} < E_{jj} < \frac{m_{H^{\pm}}^2-m_A^2}{\sqrt{s}-2\sqrt{s/4-m_{H^{\pm}}^2}}. \label{eq:Ejj}\end{aligned}$$ In our parameter set, the distribution of $E_{jj}$ for the differential cross section in this process is shown in Fig. \[fig:Ejj\]. The important background processes against this process, which are $e^+e^-\to W^{+}W^{-}\to jj\ell\overline{\nu}$ and $e^+e^-\to Z(\gamma )Z\to jj\ell\overline{\ell}$ with a missing $\overline{\ell}$ event, could be well reduced by imposing an appropriate kinematic cuts. Then, we expect that $m_{H^\pm}$ and $m_A$ can be measured by using the endpoints of $E_{jj}$ at the ILC after the background reduction. On the other hand, we consider $HA$ production: $e^+e^-\to Z^*\to HA\to AAZ^*\to AAjj$ at the ILC. If the mass difference between $m_A$ and $m_H$ is sizable, it could also be detected by using the endpoint of $E_{jj}$. However, $m_A$ and $m_H$ are almost degenerate in our scenario. When we detect $H^\pm$ but we cannot detect the clue of this process at the ILC, it seems that $m_A$ and $m_H$ are almost same value. Conclusion ========== We have studied the Higgs inflation model in the framework of a radiative seesaw scenario. In our model, we may be able to explain inflation, neutrino masses and dark matter simultaneously. We find that a part of parameter regions is compatible with all constraints which come from the conditions of the slow-roll inflation, the current LHC results, the current data from neutrino experiments and those of the dark matter abundance as well as the direct search results. We can test this scenario by measuring masses of scalar bosons at the ILC with $\sqrt{s}=500$ GeV. This work is collaboration with Shinya Kanemura and Takehiro Nabeshima. I would like to thank them for their support. [99]{} S. Kanemura, T. Matsui, T. Nabeshima and , arXiv:1211.4448 \[hep-ph\]. G. Aad [*et al.*]{} \[ATLAS Collaboration\], Phys. Lett. B [**716**]{} (2012) 1. S. Chatrchyan [*et al.*]{} \[CMS Collaboration\], Phys. Lett. B [**716**]{} (2012) 30. D. Larson [*et al.*]{}, Astrophys. J. Suppl.  [**192**]{} (2011) 16, G. Hinshaw, D. Larson, E. Komatsu, D. N. Spergel, C. L. Bennett, J. Dunkley, M. R. Nolta and M. Halpern [*et al.*]{}, arXiv:1212.5226 \[astro-ph.CO\]. P. A. R. Ade [*et al.*]{} \[ Planck Collaboration\], arXiv:1303.5062 \[astro-ph.CO\]. A. H. Guth, Phys. Rev.  D [**23**]{} (1981) 347; K. Sato, Mon. Not. Roy. Astron. Soc.  [**195**]{} (1981) 467. F. L. Bezrukov and M. Shaposhnikov, Phys. Lett. B [**659**]{} (2008) 703. A. De Simone, M. P. Hertzberg and F. Wilczek, Phys. Lett. B [**678**]{} (2009) 1; F. Bezrukov and M. Shaposhnikov, JHEP [**0907**]{} (2009) 089; J. Elias-Miro, J. R. Espinosa, G. F. Giudice, G. Isidori, A. Riotto and A. Strumia, Phys. Lett. B [**709**]{} (2012) 222; G. Degrassi, S. Di Vita, J. Elias-Miro, J. R. Espinosa, G. F. Giudice, G. Isidori and A. Strumia, JHEP [**1208**]{} (2012) 098. R. N. Lerner and J. McDonald, Phys. Rev. D [**80**]{} (2009) 123507, R. N. Lerner and J. McDonald, Phys. Rev. D [**83**]{} (2011) 123522, R. N. Lerner and J. McDonald, JCAP [**1211**]{} (2012) 019, C. Arina, J. -O. Gong and N. Sahu, Nucl. Phys. B [**865**]{} (2012) 430. J. -O. Gong, H. M. Lee and S. K. Kang, JHEP [**1204**]{} (2012) 128. C. P. Burgess, H. M. Lee and M. Trott, JHEP [**0909**]{} (2009) 103; JHEP [**1007**]{} (2010) 007; J. L. F. Barbon and J. R. Espinosa, Phys. Rev.  D [**79**]{} (2009) 081302; M. P. Hertzberg, JHEP [**1011**]{} (2010) 023. G. F. Giudice and H. M. Lee, Phys. Lett. B [**694**]{} (2011) 294. L. M. Krauss, S. Nasri and M. Trodden, Phys. Rev.  D [**67**]{} (2003) 085002; K. Cheung and O. Seto, Phys. Rev.  D [**69**]{} (2004) 113009. E. Ma, Phys. Rev.  D [**73**]{} (2006) 077301; Phys. Lett.  B [**662**]{} (2008) 49; T. Hambye, K. Kannike, E. Ma and M. Raidal, Phys. Rev.  D [**75**]{} (2007) 095003; E. Ma and D. Suematsu, Mod. Phys. Lett.  A [**24**]{} (2009) 583. M. Aoki, S. Kanemura and O. Seto, Phys. Rev. Lett.  [**102**]{} (2009) 051805; Phys. Rev.  D [**80**]{} (2009) 033007; M. Aoki, S. Kanemura and K. Yagyu, Phys. Rev.  D [**83**]{} (2011) 075016; Phys. Lett.  B [**702**]{} (2011) 355. A. D. Linde, Phys. Lett. B [**108**]{} (1982) 389; A. Albrecht and P. J. Steinhardt, Phys. Rev. Lett.  [**48**]{} (1982) 1220. E. Aprile [*et al.*]{} \[XENON100 Collaboration\], Phys. Rev. Lett.  [**109**]{} (2012) 181301. J. Brau, (Ed.) [*et al.*]{} \[ILC Collaboration\], arXiv:0712.1950 \[physics.acc-ph\]; G. Aarons [*et al.*]{} \[ILC Collaboration\], arXiv:0709.1893 \[hep-ph\]; N. Phinney, N. Toge and N. Walker, arXiv:0712.2361 \[physics.acc-ph\]; T. Behnke, (Ed.) [*et al.*]{} \[ILC Collaboration\], arXiv:0712.2356 \[physics.ins-det\]; H. Baer, [*et al.*]{} “Physics at the International Linear Collider”, [*Physics Chapter of the ILC Detailed Baseline Design Report*]{}: http://lcsim.org/papers/DBDPhysics.pdf. Y. Cui, D. E. Morrissey, D. Poland and L. Randall, JHEP [**0905**]{} (2009) 076; C. Arina, F. -S. Ling and M. H. G. Tytgat, JCAP [**0910**]{} (2009) 018. S. Kashiwase and D. Suematsu, Phys. Rev. D [**86**]{} (2012) 053001. L. Lopez Honorez, E. Nezri, J. F. Oliver and M. H. G. Tytgat, JCAP [**0702**]{} (2007) 028. K. Inoue, A. Kakuto and Y. Nakano, Prog. Theor. Phys.  [**63**]{} (1980) 234; H. Komatsu, Prog. Theor. Phys.  [**67**]{} (1982) 1177. S. Nie and M. Sher, Phys. Lett. B [**449**]{} (1999) 89; S. Kanemura, T. Kasai and Y. Okada, Phys. Lett. B [**471**]{} (1999) 182. G. Abbiendi [*et al.*]{} \[OPAL Collaboration\], Eur. Phys. J. C [**35**]{} (2004) 1; Eur. Phys. J. C [**32**]{} (2004) 453. A. Pierce and J. Thaler, JHEP [**0708**]{} (2007) 026. E. Lundstrom, M. Gustafsson and J. Edsjo, Phys. Rev. D [**79**]{} (2009) 035013. M. E. Peskin and T. Takeuchi, Phys. Rev. Lett.  [**65**]{} (1990) 964; Phys. Rev. D [**46**]{} (1992) 381. D. Toussaint, Phys. Rev. D [**18**]{} (1978) 1626; M. E. Peskin and J. D. Wells, Phys. Rev. D [**64**]{} (2001) 093003. S. Kanemura, Y. Okada, H. Taniguchi and K. Tsumura, Phys. Lett. B [**704**]{} (2011) 303; M. Baak, M. Goebel, J. Haller, A. Hoecker, D. Ludwig, K. Moenig, M. Schott and J. Stelzer, Eur. Phys. J. C [**72**]{} (2012) 2003. R. Barbieri, L. J. Hall and V. S. Rychkov, Phys. Rev. D [**74**]{} (2006) 015007 \[hep-ph/0603188\]. Q. -H. Cao, E. Ma and G. Rajasekaran, Phys. Rev. D [**76**]{} (2007) 095011. E. Dolle, X. Miao, S. Su and B. Thomas, Phys. Rev. D [**81**]{} (2010) 035003 A. Pukhov, hep-ph/0412191. M. Aoki, S. Kanemura and H. Yokoya, arXiv:1303.6191 \[hep-ph\]; M. Aoki and S. Kanemura, Phys. Lett. B [**689**]{} (2010) 28. [^1]: This proceeding paper is based on Ref. [@Kanemura:2012ha].

The short answer: a lot. The long answer: a substantial amount, my dear, it really is quite noticeable. These new comparison shots, put together by NeoGAF user Prime Blue, show some key scenes and locations early on in the game, with the 1998 Nintendo 64 version on the left and the 2011 Nintendo 3DS version on the right. Looking at the 3DS version in isolation, it's easy to get a little bummed when you compare it to, say, Twilight Princess. For those not wanting the absolute cutting edge in handheld graphics, and are just after a faithful remastering fo one of the greatest games of all time, these help put things in perspective. While we've got you, there were a couple of new pieces of Ocarina of Time 3D info released by Nintendo today. Firstly, the game will include a new mode called "Boss Mode", which lets you take on the game's bosses in isolation (or, if you want, all in a row in the one battle). It'll also include video hints for people either new to the game and stuck on a puzzle, or who are stuck, haven't played the game in over ten years and can't be bothered looking on the internet for a FAQ.

Paul Brophy Paul Brophy (April 27, 1937 – October 23, 1986) was a firefighter in Massachusetts who entered a persistent vegetative state with no believed chance of recovery. Opposing viewpoints between his family and his doctors on how to deal with his condition sparked an early legal case on the right to die. On March 22, 1983, Paul Brophy sustained a basilar artery aneurysm rupture with very destructive neurologic consequences. Following the rupture he entered a persistent vegetative state with no chance of recovery. As he was unable to chew or swallow, a gastric feeding tube was eventually inserted into him to allow for nutrition and hydration. Later, when it became obvious that there was no hope for even a modest degree of higher brain function recovery, his family requested that his gastrostomy feedings be terminated, a request based on the fact that Mr. Brophy had verbally indicated that he would not want to exist in such a degraded state. However, the hospital, New England Sinai Hospital, denied the request, leading to a series of legal actions. While the first court to hear the case agreed that Mr. Brophy would have wanted the gastrostomy tube removed, it refused to authorize its removal, principally because he was not terminally ill. However, when the case went on further to the Supreme Judicial Court of Massachusetts, transfer of Mr. Brophy to another hospital facility that was agreeable to removal of the gastrostomy tube was authorized. Mr. Brophy died a number of days later, making him the first American to die after court-authorized discontinuation of artificially supplied nutrition and hydration to a person in a persistent vegetative state. Ethical concerns over death by dehydration Judge Lynch of the Massachusetts Supreme Judicial Court argued that death by dehydration symptoms was "cruel and violent" in his opinion on this case because such a death involved: The mouth would dry out and become caked or coated with thick material. The lips would become parched and cracked. The tongue would swell, and might crack. The eyes would recede back into their orbits and the cheeks would become hollow. The lining of the nose might crack and cause the nose to bleed. The skin would hang loose on the body and become dry and scaly. The urine would become highly concentrated, leading to burning of the bladder. The lining of the stomach would dry out and the sufferer would experience dry heaves and vomiting. The body temperature would become very high. The brain cells would dry out, causing convulsions. The respiratory tract would dry out, and the thick secretions that would result could plug the lungs and cause death. At some point within five days to three weeks, the major organs, including the lungs, heart, and brain, would give out and the patient would die. While this is all true for a person who is healthy, or even relatively healthy, this does not apply to a person who is otherwise dying. The brain damage that occurs when someone is in a persistent vegetative state means the physical experience is vastly different, and these physical changes are not perceived by the person in a PVS. References Davis, John Jefferson. "BROPHY vs. NEW ENGLAND SINAI HOSPITAL: Ethical Dilemmas in Discontinuing Artificial Nutrition and Hydration for Comatose Patients", Journal of Biblical Ethics in Medicine, Volume 1, Number 3. See also Euthanasia Terri Schiavo Category:1986 deaths Category:People with severe brain damage Category:1937 births Category:People with disorders of consciousness

Q: Eigenvector computation using OpenCV I have this matrix A, representing similarities of pixel intensities of an image. For example: Consider a 10 x 10 image. Matrix A in this case would be of dimension 100 x 100, and element A(i,j) would have a value in the range 0 to 1, representing the similarity of pixel i to j in terms of intensity. I am using OpenCV for image processing and the development environment is C on Linux. Objective is to compute the Eigenvectors of matrix A and I have used the following approach: static CvMat mat, *eigenVec, *eigenVal; static double A[100][100]={}, Ain1D[10000]={}; int cnt=0; //Converting matrix A into a one dimensional array //Reason: That is how cvMat requires it for(i = 0;i < affnDim;i++){ for(j = 0;j < affnDim;j++){ Ain1D[cnt++] = A[i][j]; } } mat = cvMat(100, 100, CV_32FC1, Ain1D); cvEigenVV(&mat, eigenVec, eigenVal, 1e-300); for(i=0;i < 100;i++){ val1 = cvmGet(eigenVal,i,0); //Fetching Eigen Value for(j=0;j < 100;j++){ matX[i][j] = cvmGet(eigenVec,i,j); //Fetching each component of Eigenvector i } } Problem: After execution I get nearly all components of all the Eigenvectors to be zero. I tried different images and also tried populating A with random values between 0 and 1, but the same result. Few of the top eigenvalues returned look like the following: 9805401476911479666115491135488.000000 -9805401476911479666115491135488.000000 -89222871725331592641813413888.000000 89222862280598626902522986496.000000 5255391142666987110400.000000 I am now thinking on the lines of using cvSVD() which performs singular value decomposition of real floating-point matrix and might yield me the eigenvectors. But before that I thought of asking it here. Is there anything absurd in my current approach? Am I using the right API i.e. cvEigenVV() for the right input matrix (my matrix A is a floating point matrix)? cheers A: Note to readers: This post at first may seem unrelated to the topic, but please refer to the discussion in the comments above. The following is my attempt at implementing the Spectral Clustering algorithm applied to image pixels in MATLAB. I followed exactly the paper mentioned by @Andriyev: Andrew Ng, Michael Jordan, and Yair Weiss (2002). On spectral clustering: analysis and an algorithm. In T. Dietterich, S. Becker, and Z. Ghahramani (Eds.), Advances in Neural Information Processing Systems 14. MIT Press The code: %# parameters to tune SIGMA = 2e-3; %# controls Gaussian kernel width NUM_CLUSTERS = 4; %# specify number of clusters %% Loading and preparing a sample image %# read RGB image, and make it smaller for fast processing I0 = im2double(imread('house.png')); I0 = imresize(I0, 0.1); [r,c,~] = size(I0); %# reshape into one row per-pixel: r*c-by-3 %# (with pixels traversed in columwise-order) I = reshape(I0, [r*c 3]); %% 1) Compute affinity matrix %# for each pair of pixels, apply a Gaussian kernel %# to obtain a measure of similarity A = exp(-SIGMA * squareform(pdist(I,'euclidean')).^2); %# and we plot the matrix obtained imagesc(A) axis xy; colorbar; colormap(hot) %% 2) Compute the Laplacian matrix L D = diag( 1 ./ sqrt(sum(A,2)) ); L = D*A*D; %% 3) perform an eigen decomposition of the laplacian marix L [V,d] = eig(L); %# Sort the eigenvalues and the eigenvectors in descending order. [d,order] = sort(real(diag(d)), 'descend'); V = V(:,order); %# kepp only the largest k eigenvectors %# In this case 4 vectors are enough to explain 99.999% of the variance NUM_VECTORS = sum(cumsum(d)./sum(d) < 0.99999) + 1; V = V(:, 1:NUM_VECTORS); %% 4) renormalize rows of V to unit length VV = bsxfun(@rdivide, V, sqrt(sum(V.^2,2))); %% 5) cluster rows of VV using K-Means opts = statset('MaxIter',100, 'Display','iter'); [clustIDX,clusters] = kmeans(VV, NUM_CLUSTERS, 'options',opts, ... 'distance','sqEuclidean', 'EmptyAction','singleton'); %% 6) assign pixels to cluster and show the results %# assign for each pixel the color of the cluster it belongs to clr = lines(NUM_CLUSTERS); J = reshape(clr(clustIDX,:), [r c 3]); %# show results figure('Name',sprintf('Clustering into K=%d clusters',NUM_CLUSTERS)) subplot(121), imshow(I0), title('original image') subplot(122), imshow(J), title({'clustered pixels' '(color-coded classes)'}) ... and using a simple house image I drew in Paint, the results were: and by the way, the first 4 eigenvalues used were: 1.0000 0.0014 0.0004 0.0002 and the corresponding eigenvectors [columns of length r*c=400]: -0.0500 0.0572 -0.0112 -0.0200 -0.0500 0.0553 0.0275 0.0135 -0.0500 0.0560 0.0130 0.0009 -0.0500 0.0572 -0.0122 -0.0209 -0.0500 0.0570 -0.0101 -0.0191 -0.0500 0.0562 -0.0094 -0.0184 ...... Note that there are step performed above which you didn't mention in your question (Laplacian matrix, and normalizing its rows)

Antoine L'Estage Antoine L'Estage is the most successful Canadian rally driver ever. He has won national championships in both the Canada and the USA. He lives in St-Jean-sur-Richelieu, Québec. Rally Antoine L'Estage was born into the world of rally. As a young boy, he and his siblings would watch their father compete as a driver. He started racing in 1995 at the Rallye de Quebec in regional events. He won Rookie of the year for the 2001 season for the Canadian Rally Championship. He won the Canadian championship in 2006, 2007, and eight in a row from 2010 to 2017, coming second to Patrick Richard in 2004, 2008 and 2009. In 2011, he broke the record of most wins at Défi St-Agathe Rallye (previously set by John Buffum) when he won the event for the sixth time in seven years. In 2014 he became the first 7-time champion as well as the first driver in the history of the CRC to win all six events in the same season. Beginning the 2015 season, Antoine L'Estage joined the Subaru Rally Team Canada (SRTC) and became the driver of the SRTC 2015 Subaru WRX STI with anticipation of being the quickest car, driver and team to ever compete in the CRC. Subaru Rally Team Canada is managed in cooperation with Rocket Rally Racing (RRR) and Patrick Richard, based out of Squamish, BC. The SRTC 2015 Subaru WRX STI was developed at the RRR facility. Antoine also competed in the USA-based Rally America series from 2006 to 2015. He won the North American Rally Cup in 2007, 2008, and from 2010 to 2014, coming second to Andrew Comrie-Picard in 2009. In 2010, Antoine ended Travis Pastrana's four-year reign over the Rally America championship. He later claimed the North American and the Canadian Rally Championships and secured the Triple Crown for 2010 by winning all three titles in the same year. In 2011 and 2012 Antoine completed the Rally America series as runner-up behind former British champion David Higgins. In 2013 he rented a MML Sports built WRC-spec Mitsubishi Lancer for the Oregon Trail Rally, but crashed in a spectacular incident, hitting a tree at the base of a cliff. He competed three times in Rally Car Racing at X Games. He raced his Hyundai Tiburon for X Games 13, borrowed a Rockstar Energy Subaru for X Games 14, finishing ninth, and then he took his Mitsubishi Evo X to a Bronze medal finish at X Games 16 in 2010. He has also been a test driver on a show in Quebec called Le Guide de l'Auto. Canadian Rally Championship Results As of November 2015, Antoine L'Estage became the most successful Canadian rally driver ever, overtaking Taisto Heinonen at 5590 lifetime pts, and tying with John Buffum for most wins at 43. L'Estage went on to win 4 events in the 2016 season on his way to his ninth Canadian Championship, and he was inducted into the Canadian Motorsport Hall of Fame in October 2016. Complete Rally America results Personal life See also Canadian Rally Championship Rally America Mitsubishi Evo References External links https://web.archive.org/web/20111026081156/http://espn.go.com/action/athlete/_/id/44843/antoine-l%27estage https://web.archive.org/web/20120425081343/http://www.coyoterallye.com/profile http://www.rallyracingnews.com/cars/crc-standing.html Category:1973 births Category:Living people Category:Canadian rally drivers Category:Place of birth missing (living people) Category:People from Saint-Jean-sur-Richelieu Category:Sportspeople from Quebec

Alasdair Fraser Master Scottish fiddler Alasdair Fraser is a consummate performer. His dynamic fiddling, engaging stage presence, and deep understanding of Scotland's music have created a constant and international demand for his solo appearances and concerts with a variety of ensembles. Alasdair has been a major force behind the resurgence of traditional Scottish fiddling in his homeland and the U.S., inspiring legions of listeners and learners through his recordings, annual fiddle camps, and concerts. He has represented Scotland internationally through performances sponsored by the British Council, and has been awarded touring support by the California Arts Council, with the ranking of "highest priority for inclusion on the roster; considered 'model' in stature." Alasdair's richly expressive playing transports listeners across a broad musical spectrum, ranging from haunting laments from the Gaelic tradition to classically-styled airs, raucous dance tunes, and improvisations based on traditional themes. His vast repertoire spans several centuries of Scottish music and includes his own compositions, which blend a profound understanding of the Scottish tradition with cutting-edge musical explorations. He weaves through his performances a warm and witty narrative, drawing from a deep well of stories and lore surrounding Scotland's musical heritage.

Matt Burton Matt Burton is an Australian professional rugby league footballer who plays as a or for the Penrith Panthers in the NRL. Background Burton was born in Dubbo, New South Wales, Australia. He played his junior rugby league for St Johns and Dubbo CYMS in the Group 11 Rugby League. Career Burton made his first grade debut for Penrith against the Cronulla-Sutherland Sharks in round 21 of the 2019 NRL season which ended in a 26–20 victory for Penrith at Panthers Stadium. References External links Penrith Panthers profile Category:2000 births Category:Australian rugby league players Category:Penrith Panthers players Category:Rugby league five-eighths Category:Living people

<?xml version='1.0' encoding='utf-8'?> <SettingsFile xmlns="http://schemas.microsoft.com/VisualStudio/2004/01/settings" CurrentProfile="(Default)"> <Profiles> <Profile Name="(Default)" /> </Profiles> <Settings /> </SettingsFile>

Clara J. Peck Clara Jane Thornton Peck (March 1, 1862 – 15 June 1926) was an English-born American public health nurse and hospital matron, based in Greensboro, North Carolina. Early life and education Clara Jane Thornton was born at Stroud, Gloucestershire in 1862, one of the five children of John Thornton and Jane Thornton. The Thorntons emigrated in 1872, settling first in Pittsburgh, Pennsylvania, where Clara attended the Pershing Conservatory of Music and was a soloist in her church choir. Career In 1898 she moved to Greensboro, North Carolina. In 1901, as a 39-year-old widow, she trained as a nurse at Greensboro Hospital, and showed such aptitude that she was soon the hospital's first matron. By 1909, "Mother Peck" had the experience and reputation to be selected as Greensboro's first district nurse, by the newly formed District Nurse and Relief Association, and paid by a public subscription drive. Every month, she attended hundreds patients in need, usually in their homes, and became a common sight walking between visits. Her experiences in the community gave her a close familiarity with tuberculosis, and insights into possible preventive measures. She became head of a small tuberculosis hospital in town, and in 1923, was a founder of North Carolina's first county-supported sanatorium. She also worked with the local American Red Cross chapter during the 1918 flu pandemic. She was so much a community institution that, when she was knocked unconscious by a hit-and-run driver in 1921, a reward was raised to find the culprit. Said one Greensboro doctor and colleague, "Nurses, like poets, are born, not made, and Mrs. Peck is a shining example of this truth." Personal life Thornton married Delbert Stephen Peck in 1883. They had three children; a son died young, and two daughters, Saza and Cora, survived Clara. She was widowed when Delbert Peck died in 1899. Clara Peck died in 1926, age 64. An elementary school in the Glenwood section of Greensboro has been named for Clara J. Peck since 1929. The county sanatorium Peck helped to found is now the site of the Guilford Technical Community College. References External links Category:1862 births Category:1926 deaths Category:People from Greensboro, North Carolina Category:American nurses Category:American women nurses Category:People from Stroud Category:English emigrants to the United States

According to a report from MMA Team Dagestan, a Twitter account that has produced a number of high-profile scoops in recent weeks, the hunt for UFC lightweight champion Khabib Nurmagomedov’s next opponent is down to two men. The priority, of course, is former UFC lightweight and featherweight champion Conor McGregor. If negotiations with the Irish superstar fizzle out, however, the UFC is reportedly planning to announce a fight between Nurmagomedov and Tony Ferguson. Either way, the fight will reportedly occur at UFC 229 on October 6. Over the last few weeks, there has been ample reason to believe a Nurmagomedov vs. McGregor could soon happen. McGregor’s coaches Owen Roddy and John Kavanagh have both implied negotiations could be percolating, while Nurmagomedov himself has stated the bout is in the works. “Very soon I’m going to come to USA, to California and begin my training camp,” Nurmagomedov said on the social media platform Live Raise in late June. “When the UFC give me fight I’m going to come to California and I’m going to stay at [American Kickboxing Academy] for nine weeks with my family before the fight and I’m going to defend my title.” “This year I want to defend my title. About opponents? I don’t know to be honest. I don’t know, but the UFC are working on a fight versus Conor [McGregor].” If the fight doesn’t happen, and the UFC does indeed book a UFC 229 bout between Khabib Nurmagomedov and Tony Ferguson, it will be their fifth attempt at doing so. On each of the four previous occasions the promotion has attempted to book the fight, one man or the other has been forced to withdraw. UPDATE: Since the publication of this article, Khabib Nurmagomedov’s manager Ali Abdelaziz has claimed that Nurmagomedov will not be fighting Ferguson.

WILKINS ELKS 577 LODGE: CHRISTMAS CRAFT & BAKE SALE SATURDAY DECEMBER 3RD 10:00 a.m. to 4:00 p.m.: Annual Christmas Craft & Bake Sale is being held at the Wilkins Elks Lodge. We will have over 25 of your neighbors selling homemade crafts, jewelry, apparel and fabulous holiday decor as well as your favorite home business vendors selling jewelry and cosmetics. The ladies of the Century Club, a tradition at the Christmas Craft Sale will be selling their homemade cookies, cakes, pies and candies just in time for Christmas visits and celebrations. BIG 50/50 and Vendor Basket Raffle. Plus homemade lunch items and snacks will be for sale. ALL Proceeds directly benefit the Wilkins Elks Home Services Program which provides an RN Advocate for families and children with special needs. Call 412.823.6300 for more information. Wilkins Elks 577 Lodge, 718 Brown Avenue, Turtle Creek (next to Kuhns) - See more at: http://calendar.triblive.com/event/annual-christmas-craft-bake-sale-at-the-wilkins-elks-577-lodge-566074a6e5a30#sthash.mkx2NYgD.dpuf

Q: How to retrieve configuration from a marklogic server with Roxy I'm starting to use Roxy to configure my marklogic cluster (version 8). This tool allow me to deploy my configuration on many "clusters" and avoid to do it manually. During my tests, I configured a cluster manually (through the web administration - port 8001). I'm wondering if it's possible to retrieve this configuration from the server to my local computer. I'd like to get it locally to use it for my futures deployment. Thanks. Regards, Romain A: Try this great write-up by Geert: http://grtjn.blogspot.nl/2014/10/capturing-marklogic-applications-with.html The sample mentions version 7, but Roxy works fine with Version 8 as well.

Q: Where can I store my plist online for free and my app can download it? I have an app where it downloads the latest .plist from a URL. Is there a website where I can upload my plist file for free and when users go on my app, it will download the plist with no hassle? At the moment my app is looking at the plist locally. I want to store my file online so any changes I make, can be uploaded by me and then downloaded when the app is used. Any help would be great. Thanks A: You can store it online using a free hosted website, like the ones provided by en.altervista.org: the site looks like a subdomain (e.g. bigsman.altervista.org), it has got FTP access and other features, all free. It's the best free solution in my humble opinion. I've already use it in some of my projects, and everything went fine.

RUSSIA PARLIAMENT VOTES TO STRENGTHEN KGB SUCCESSOR June 14, 2010 Russia's parliament on Friday voted to boost the powers of the successor to the Soviet KGB, allowing it to summon people it believes are about to commit a crime and threaten jail for those who disobey its orders. Rights groups said the proposed regulations could be used by the FSB security service to detain opposition activists and independent journalists and undermine President Dmitry Medvedev's promises to foster civil rights. "It's a step toward a police state," said Vladimir Ulas, a member of the opposition Communist Party. "It is effectively a ban on any real opposition activity." The bill, which would allow the FSB to issue a legally binding summons to anyone whose actions it considers as "causing or creating the conditions for committing a crime," was passed in the first of three required readings in the State Duma. All 313 members of Prime Minister Vladimir Putin's United Russia party present voted in favor, while the Communists joined the smaller pro-Kremlin parties, Fair Russia and the Liberal Democrats, in opposing the bill. Gennady Gudkov, whose Fair Russia party rarely opposes government-backed legislation, described it as "a leftover order from the Soviet Union." He said he would lobby for changes to the bill before the second reading. It also needs approval by the United Russia-dominated upper house and Medvedev's signature. The bill would set a penalty of up to 15 days in prison for anyone who "disobeys a legitimate order" from an FSB agent. Rights groups say the changes taken together could allow the FSB to detain anyone it likes without any judicial process. "A warning sounds benign, but under Russian law it can have serious consequences," said Allison Gill, Moscow director of New York-based Human Rights Watch. "It is a significant increase in power for the FSB."

Q: Minha url do css não está funcionando no codeigniter Bom dia, estou aprendendo a usar o codeigniter, e estou com um problema no meu css... dentro da pasta applications eu criei uma outra pasta chamada layout, que dentro dele vai possuir um header.php e um footer.php. Quando eu acessar minha view eu chamo esse header e footer. Até ai ok! na pasta applications também possui uma outra pasta chamada assets que dentro tem as seguintes pastas - css e sass. No meu header, eu não estou conseguindo atingir o arquivo css... no meu autoload configurei a url, e na minha config.php a url padrão está desta forma: $config['base_url'] = 'http://localhost:8888/project_system_hair/project/system_hair/'; e no meu header.php está assim: <link rel="stylesheet" type="text/css" href="<?=base_url('assets/css/teste.css')?>"> Ao executar e dando inspect de element o meu href fica desta forma... <link rel="stylesheet" type="text/css" href="http://localhost:8888/project_system_hair/project/system_hair/assets/css/teste.css"> Ou seja o caminho está certo... mas o console acusa um erro dizendo: GET http://localhost:8888/project_system_hair/project/system_hair/assets/css/teste.css net::ERR_ABORTED e assim não consigo usar meu css. OBS: o caminho da minha pasta dentro do notebook: /Applications/MAMP/htdocs/project_system_hair/project/system_hair/application/assets/css Alguém poderia me ajudar? Obrigado.... A: Consegui solucionar o meu problema.... Pelo que estava vendo, mesmo se a minha url base estiver apontada para application, tera que por o resto do caminho. A minha solução foi, por o application/ antes ficando desta forma: <link rel="stylesheet" type="text/css" href="<?=base_url('application/assets/css/teste.css')?>"> Desta forma, o meu css esta "linkado" corretamente Obrigado pessoal

Information systems have evolved from centralized mainframe computer systems supporting a large number of users to distributed computer systems based on local area network (LAN) architectures. As the cost-to-processing-power ratios for desktop PCs and network servers have dropped precipitously, LAN systems have proved to be highly cost effective. As a result, the number of LANs and LAN-based applications has exploded. A consequential development relating to the increased popularity of LANs has been the interconnection of remote LANs, computers, and other equipment into wide area networks (WANs) in order to make more resources available to users. However, a LAN backbone can transmit data between users at high bandwidth rates for only relatively short distances. In order to interconnect devices across large distances, different communication protocols have been developed. These include packet switching protocols, such as X.25, ISDN, frame relay, and ATM, among others. Packet switching involves the transmission of data in packets through a network. Each block of end-user data that is to be transmitted is divided into packets. A unique identifier, a sequence number and a destination address are attached to each data packet. The packets are independent and may traverse the data network by different routes. The packets may incur different levels of propagation delay, or latency, caused by physical paths of different length. The packets may also be held for varying amounts of delay time in packet buffers in intermediated switches in the network. The packets may also be switched through differing numbers of packet switches as they traverse the network, wherein each switch has an associated processing delay caused by error detection and correction. As a result, the packets may arrive out-of-order at the destination node. However, the destination node uses the identification and sequencing information in each data packet to assemble the data packets back in the proper order before continuing to process the original end-user data block. To enhance the reliability of a packet switched network, it is common practice to build the packet switches as redundant devices. Each packet switch contains a primary (also called "master" or "active") packet routing engine that ordinarily performs packet routing and a secondary (also called "slave" or "standby") packet routing engine that takes over from the primary packet routing engine upon failure or upon the occurrence of certain selected events. However, the switchover (or failover) from a primary to a secondary packet routing engine is frequently a disruptive event. At the time of switchover, the primary packet routing engine typically contains unprocessed data packets in input buffers, processed data packets in output buffers, and in-process data packets that are currently being processed by the control processor of the primary packet routing engine. Since the in-process data may affect the contents of both the input buffers and the output buffers, the loss of this in-process data during switchover to the secondary causes service disruptions. There is therefore a need in the art for an improved redundant data packet switch that provides a more seamless switchover from a primary packet routing engine to a secondary packet routing engine. In particular, there is a need in the art for an improved redundant data packet switch in which the secondary packet routing engine is able to identify in-process data held in the primary packet routing engine and is able to correctly re-process such in-process data after a switch-over has occurred.

app_trace_util.o: \ D:/Project/ESP32/sdk/esp-idf-v3.0/components/app_trace/app_trace_util.c \ D:/Project/ESP32/sdk/esp-idf-v3.0/components/freertos/include/freertos/FreeRTOS.h \ D:/Project/ESP32/sdk/esp-idf-v3.0/components/newlib/include/sys/reent.h \ D:/Project/ESP32/sdk/esp-idf-v3.0/components/newlib/include/_ansi.h \ D:/Project/ESP32/sdk/esp-idf-v3.0/components/newlib/include/newlib.h \ D:/Project/ESP32/sdk/esp-idf-v3.0/components/newlib/include/sys/config.h \ D:/Project/ESP32/sdk/esp-idf-v3.0/components/newlib/include/machine/ieeefp.h \ D:/Project/ESP32/sdk/esp-idf-v3.0/components/newlib/include/sys/features.h \ D:/Project/ESP32/sdk/esp-idf-v3.0/components/esp32/include/xtensa/config/core-isa.h \ D:/Project/ESP32/sdk/esp-idf-v3.0/components/newlib/include/sys/_types.h \ D:/Project/ESP32/sdk/esp-idf-v3.0/components/newlib/include/machine/_types.h \ D:/Project/ESP32/sdk/esp-idf-v3.0/components/newlib/include/machine/_default_types.h \ D:/Project/ESP32/sdk/esp-idf-v3.0/components/newlib/include/sys/lock.h \ D:/Project/ESP32/sdk/esp-idf-v3.0/components/newlib/include/stdint.h \ D:/Project/ESP32/sdk/esp-idf-v3.0/components/newlib/include/sys/_intsup.h \ D:/Project/ESP32/sdk/esp-idf-v3.0/components/freertos/include/freertos/FreeRTOSConfig.h \ D:/Project/ESP32/sdk/esp-idf-v3.0/app/build/include/sdkconfig.h \ D:/Project/ESP32/sdk/esp-idf-v3.0/components/freertos/include/freertos/xtensa_config.h \ D:/Project/ESP32/sdk/esp-idf-v3.0/components/esp32/include/xtensa/hal.h \ D:/Project/ESP32/sdk/esp-idf-v3.0/components/esp32/include/xtensa/config/core.h \ D:/Project/ESP32/sdk/esp-idf-v3.0/components/esp32/include/xtensa/xtensa-versions.h \ D:/Project/ESP32/sdk/esp-idf-v3.0/components/esp32/include/xtensa/config/core-matmap.h \ D:/Project/ESP32/sdk/esp-idf-v3.0/components/esp32/include/xtensa/config/tie.h \ D:/Project/ESP32/sdk/esp-idf-v3.0/components/esp32/include/xtensa/config/system.h \ D:/Project/ESP32/sdk/esp-idf-v3.0/components/freertos/include/freertos/xtensa_context.h \ D:/Project/ESP32/sdk/esp-idf-v3.0/components/esp32/include/xtensa/corebits.h \ D:/Project/ESP32/sdk/esp-idf-v3.0/components/esp32/include/xtensa/xtruntime-frames.h \ D:/Project/ESP32/sdk/esp-idf-v3.0/components/newlib/include/stdlib.h \ D:/Project/ESP32/sdk/esp-idf-v3.0/components/newlib/include/_ansi.h \ D:/Project/ESP32/sdk/esp-idf-v3.0/components/newlib/include/sys/cdefs.h \ D:/Project/ESP32/sdk/esp-idf-v3.0/components/newlib/include/machine/stdlib.h \ D:/Project/ESP32/sdk/esp-idf-v3.0/components/newlib/include/alloca.h \ D:/Project/ESP32/sdk/esp-idf-v3.0/components/esp32/include/rom/ets_sys.h \ D:/Project/ESP32/sdk/esp-idf-v3.0/components/soc/esp32/include/soc/soc.h \ D:/Project/ESP32/sdk/esp-idf-v3.0/components/esp32/include/esp_assert.h \ D:/Project/ESP32/sdk/esp-idf-v3.0/components/newlib/platform_include/assert.h \ D:/Project/ESP32/sdk/esp-idf-v3.0/components/newlib/include/assert.h \ D:/Project/ESP32/sdk/esp-idf-v3.0/components/freertos/include/freertos/projdefs.h \ D:/Project/ESP32/sdk/esp-idf-v3.0/components/freertos/include/freertos/portable.h \ D:/Project/ESP32/sdk/esp-idf-v3.0/components/freertos/include/freertos/deprecated_definitions.h \ D:/Project/ESP32/sdk/esp-idf-v3.0/components/freertos/include/freertos/portmacro.h \ D:/Project/ESP32/sdk/esp-idf-v3.0/components/esp32/include/xtensa/tie/xt_core.h \ D:/Project/ESP32/sdk/esp-idf-v3.0/components/esp32/include/xtensa/xtruntime.h \ D:/Project/ESP32/sdk/esp-idf-v3.0/components/esp32/include/xtensa/config/specreg.h \ D:/Project/ESP32/sdk/esp-idf-v3.0/components/esp32/include/xtensa/xtruntime-core-state.h \ D:/Project/ESP32/sdk/esp-idf-v3.0/components/esp32/include/esp_crosscore_int.h \ D:/Project/ESP32/sdk/esp-idf-v3.0/components/esp32/include/esp_timer.h \ D:/Project/ESP32/sdk/esp-idf-v3.0/components/newlib/include/stdio.h \ D:/Project/ESP32/sdk/esp-idf-v3.0/components/newlib/include/sys/types.h \ D:/Project/ESP32/sdk/esp-idf-v3.0/components/newlib/include/machine/types.h \ D:/Project/ESP32/sdk/esp-idf-v3.0/components/newlib/include/sys/sched.h \ D:/Project/ESP32/sdk/esp-idf-v3.0/components/newlib/include/sys/stdio.h \ D:/Project/ESP32/sdk/esp-idf-v3.0/components/esp32/include/esp_err.h \ D:/Project/ESP32/sdk/esp-idf-v3.0/components/heap/include/esp_heap_caps.h \ D:/Project/ESP32/sdk/esp-idf-v3.0/components/heap/include/multi_heap.h \ D:/Project/ESP32/sdk/esp-idf-v3.0/components/soc/include/soc/soc_memory_layout.h \ D:/Project/ESP32/sdk/esp-idf-v3.0/components/esp32/include/esp_attr.h \ D:/Project/ESP32/sdk/esp-idf-v3.0/components/freertos/include/freertos/portbenchmark.h \ D:/Project/ESP32/sdk/esp-idf-v3.0/components/freertos/include/freertos/mpu_wrappers.h \ D:/Project/ESP32/sdk/esp-idf-v3.0/components/esp32/include/esp_system.h \ D:/Project/ESP32/sdk/esp-idf-v3.0/components/esp32/include/esp_sleep.h \ D:/Project/ESP32/sdk/esp-idf-v3.0/components/driver/include/driver/gpio.h \ D:/Project/ESP32/sdk/esp-idf-v3.0/components/esp32/include/esp_types.h \ D:/Project/ESP32/sdk/esp-idf-v3.0/components/soc/esp32/include/soc/gpio_reg.h \ D:/Project/ESP32/sdk/esp-idf-v3.0/components/soc/esp32/include/soc/soc.h \ D:/Project/ESP32/sdk/esp-idf-v3.0/components/soc/esp32/include/soc/gpio_struct.h \ D:/Project/ESP32/sdk/esp-idf-v3.0/components/soc/esp32/include/soc/rtc_io_reg.h \ D:/Project/ESP32/sdk/esp-idf-v3.0/components/soc/esp32/include/soc/io_mux_reg.h \ D:/Project/ESP32/sdk/esp-idf-v3.0/components/soc/esp32/include/soc/gpio_sig_map.h \ D:/Project/ESP32/sdk/esp-idf-v3.0/components/esp32/include/rom/gpio.h \ D:/Project/ESP32/sdk/esp-idf-v3.0/components/esp32/include/esp_intr_alloc.h \ D:/Project/ESP32/sdk/esp-idf-v3.0/components/driver/include/driver/touch_pad.h \ D:/Project/ESP32/sdk/esp-idf-v3.0/components/esp32/include/esp_intr.h \ D:/Project/ESP32/sdk/esp-idf-v3.0/components/esp32/include/rom/ets_sys.h \ D:/Project/ESP32/sdk/esp-idf-v3.0/components/freertos/include/freertos/xtensa_api.h \ D:/Project/ESP32/sdk/esp-idf-v3.0/components/soc/esp32/include/soc/touch_channel.h \ D:/Project/ESP32/sdk/esp-idf-v3.0/components/freertos/include/freertos/task.h \ D:/Project/ESP32/sdk/esp-idf-v3.0/components/newlib/include/limits.h \ D:/Project/ESP32/sdk/esp-idf-v3.0/components/freertos/include/freertos/list.h \ D:/Project/ESP32/sdk/esp-idf-v3.0/components/app_trace/include/esp_app_trace_util.h \ D:/Project/ESP32/sdk/esp-idf-v3.0/components/esp32/include/esp_clk.h D:/Project/ESP32/sdk/esp-idf-v3.0/components/freertos/include/freertos/FreeRTOS.h: D:/Project/ESP32/sdk/esp-idf-v3.0/components/newlib/include/sys/reent.h: D:/Project/ESP32/sdk/esp-idf-v3.0/components/newlib/include/_ansi.h: D:/Project/ESP32/sdk/esp-idf-v3.0/components/newlib/include/newlib.h: D:/Project/ESP32/sdk/esp-idf-v3.0/components/newlib/include/sys/config.h: D:/Project/ESP32/sdk/esp-idf-v3.0/components/newlib/include/machine/ieeefp.h: D:/Project/ESP32/sdk/esp-idf-v3.0/components/newlib/include/sys/features.h: D:/Project/ESP32/sdk/esp-idf-v3.0/components/esp32/include/xtensa/config/core-isa.h: D:/Project/ESP32/sdk/esp-idf-v3.0/components/newlib/include/sys/_types.h: D:/Project/ESP32/sdk/esp-idf-v3.0/components/newlib/include/machine/_types.h: D:/Project/ESP32/sdk/esp-idf-v3.0/components/newlib/include/machine/_default_types.h: D:/Project/ESP32/sdk/esp-idf-v3.0/components/newlib/include/sys/lock.h: D:/Project/ESP32/sdk/esp-idf-v3.0/components/newlib/include/stdint.h: D:/Project/ESP32/sdk/esp-idf-v3.0/components/newlib/include/sys/_intsup.h: D:/Project/ESP32/sdk/esp-idf-v3.0/components/freertos/include/freertos/FreeRTOSConfig.h: D:/Project/ESP32/sdk/esp-idf-v3.0/app/build/include/sdkconfig.h: D:/Project/ESP32/sdk/esp-idf-v3.0/components/freertos/include/freertos/xtensa_config.h: D:/Project/ESP32/sdk/esp-idf-v3.0/components/esp32/include/xtensa/hal.h: D:/Project/ESP32/sdk/esp-idf-v3.0/components/esp32/include/xtensa/config/core.h: D:/Project/ESP32/sdk/esp-idf-v3.0/components/esp32/include/xtensa/xtensa-versions.h: D:/Project/ESP32/sdk/esp-idf-v3.0/components/esp32/include/xtensa/config/core-matmap.h: D:/Project/ESP32/sdk/esp-idf-v3.0/components/esp32/include/xtensa/config/tie.h: D:/Project/ESP32/sdk/esp-idf-v3.0/components/esp32/include/xtensa/config/system.h: D:/Project/ESP32/sdk/esp-idf-v3.0/components/freertos/include/freertos/xtensa_context.h: D:/Project/ESP32/sdk/esp-idf-v3.0/components/esp32/include/xtensa/corebits.h: D:/Project/ESP32/sdk/esp-idf-v3.0/components/esp32/include/xtensa/xtruntime-frames.h: D:/Project/ESP32/sdk/esp-idf-v3.0/components/newlib/include/stdlib.h: D:/Project/ESP32/sdk/esp-idf-v3.0/components/newlib/include/_ansi.h: D:/Project/ESP32/sdk/esp-idf-v3.0/components/newlib/include/sys/cdefs.h: D:/Project/ESP32/sdk/esp-idf-v3.0/components/newlib/include/machine/stdlib.h: D:/Project/ESP32/sdk/esp-idf-v3.0/components/newlib/include/alloca.h: D:/Project/ESP32/sdk/esp-idf-v3.0/components/esp32/include/rom/ets_sys.h: D:/Project/ESP32/sdk/esp-idf-v3.0/components/soc/esp32/include/soc/soc.h: D:/Project/ESP32/sdk/esp-idf-v3.0/components/esp32/include/esp_assert.h: D:/Project/ESP32/sdk/esp-idf-v3.0/components/newlib/platform_include/assert.h: D:/Project/ESP32/sdk/esp-idf-v3.0/components/newlib/include/assert.h: D:/Project/ESP32/sdk/esp-idf-v3.0/components/freertos/include/freertos/projdefs.h: D:/Project/ESP32/sdk/esp-idf-v3.0/components/freertos/include/freertos/portable.h: D:/Project/ESP32/sdk/esp-idf-v3.0/components/freertos/include/freertos/deprecated_definitions.h: D:/Project/ESP32/sdk/esp-idf-v3.0/components/freertos/include/freertos/portmacro.h: D:/Project/ESP32/sdk/esp-idf-v3.0/components/esp32/include/xtensa/tie/xt_core.h: D:/Project/ESP32/sdk/esp-idf-v3.0/components/esp32/include/xtensa/xtruntime.h: D:/Project/ESP32/sdk/esp-idf-v3.0/components/esp32/include/xtensa/config/specreg.h: D:/Project/ESP32/sdk/esp-idf-v3.0/components/esp32/include/xtensa/xtruntime-core-state.h: D:/Project/ESP32/sdk/esp-idf-v3.0/components/esp32/include/esp_crosscore_int.h: D:/Project/ESP32/sdk/esp-idf-v3.0/components/esp32/include/esp_timer.h: D:/Project/ESP32/sdk/esp-idf-v3.0/components/newlib/include/stdio.h: D:/Project/ESP32/sdk/esp-idf-v3.0/components/newlib/include/sys/types.h: D:/Project/ESP32/sdk/esp-idf-v3.0/components/newlib/include/machine/types.h: D:/Project/ESP32/sdk/esp-idf-v3.0/components/newlib/include/sys/sched.h: D:/Project/ESP32/sdk/esp-idf-v3.0/components/newlib/include/sys/stdio.h: D:/Project/ESP32/sdk/esp-idf-v3.0/components/esp32/include/esp_err.h: D:/Project/ESP32/sdk/esp-idf-v3.0/components/heap/include/esp_heap_caps.h: D:/Project/ESP32/sdk/esp-idf-v3.0/components/heap/include/multi_heap.h: D:/Project/ESP32/sdk/esp-idf-v3.0/components/soc/include/soc/soc_memory_layout.h: D:/Project/ESP32/sdk/esp-idf-v3.0/components/esp32/include/esp_attr.h: D:/Project/ESP32/sdk/esp-idf-v3.0/components/freertos/include/freertos/portbenchmark.h: D:/Project/ESP32/sdk/esp-idf-v3.0/components/freertos/include/freertos/mpu_wrappers.h: D:/Project/ESP32/sdk/esp-idf-v3.0/components/esp32/include/esp_system.h: D:/Project/ESP32/sdk/esp-idf-v3.0/components/esp32/include/esp_sleep.h: D:/Project/ESP32/sdk/esp-idf-v3.0/components/driver/include/driver/gpio.h: D:/Project/ESP32/sdk/esp-idf-v3.0/components/esp32/include/esp_types.h: D:/Project/ESP32/sdk/esp-idf-v3.0/components/soc/esp32/include/soc/gpio_reg.h: D:/Project/ESP32/sdk/esp-idf-v3.0/components/soc/esp32/include/soc/soc.h: D:/Project/ESP32/sdk/esp-idf-v3.0/components/soc/esp32/include/soc/gpio_struct.h: D:/Project/ESP32/sdk/esp-idf-v3.0/components/soc/esp32/include/soc/rtc_io_reg.h: D:/Project/ESP32/sdk/esp-idf-v3.0/components/soc/esp32/include/soc/io_mux_reg.h: D:/Project/ESP32/sdk/esp-idf-v3.0/components/soc/esp32/include/soc/gpio_sig_map.h: D:/Project/ESP32/sdk/esp-idf-v3.0/components/esp32/include/rom/gpio.h: D:/Project/ESP32/sdk/esp-idf-v3.0/components/esp32/include/esp_intr_alloc.h: D:/Project/ESP32/sdk/esp-idf-v3.0/components/driver/include/driver/touch_pad.h: D:/Project/ESP32/sdk/esp-idf-v3.0/components/esp32/include/esp_intr.h: D:/Project/ESP32/sdk/esp-idf-v3.0/components/esp32/include/rom/ets_sys.h: D:/Project/ESP32/sdk/esp-idf-v3.0/components/freertos/include/freertos/xtensa_api.h: D:/Project/ESP32/sdk/esp-idf-v3.0/components/soc/esp32/include/soc/touch_channel.h: D:/Project/ESP32/sdk/esp-idf-v3.0/components/freertos/include/freertos/task.h: D:/Project/ESP32/sdk/esp-idf-v3.0/components/newlib/include/limits.h: D:/Project/ESP32/sdk/esp-idf-v3.0/components/freertos/include/freertos/list.h: D:/Project/ESP32/sdk/esp-idf-v3.0/components/app_trace/include/esp_app_trace_util.h: D:/Project/ESP32/sdk/esp-idf-v3.0/components/esp32/include/esp_clk.h: /d/Project/ESP32/sdk/esp-idf-v3.0/components/app_trace/./app_trace_util.c:

YODA PRESS A LITTLE BOOK ON MEN by Rahul Roy India today is abuzz about how things are changing for the new Indian woman. Yet no one is talking about men. As the varied discourses within gender studies grow increasingly complex, the study of masculinities continues to remain an area of darkness within the South Asian reality. The obvious is familiar to all---the visible, hegemonic masculinity which bristles on the slightest provocation and proudly displays its wares. But what about various other masculinities, those which remain silent and unrecognized, pushed under and behind their ‘hyper masculine’ brethren? One might ask---are the two kinds of masculinities locked in an eternal conflict? And are these masculinities permanent, unchangeable, or do they evolve and transform with time? An unprecedented and timely effort, A Little Book on Men, attempts to address many of these questions in a creative and reader-friendly manner through drawings, text, and video frames. Drawing on popular culture, socialization charts used in schools, poetry, personal narratives and documentary footage, this unique book brings together the main theories, key concepts and empirical research on masculinities even as it contributes to the construction of a language which men in South Asia can use to talk about themselves in different and individually distinct ways.

Q: Possible timezone parsing error in outlook I'm trying to make sure this is a problem with outlook. I am generating an ics file that specifies the timezone of the event: BEGIN:VCALENDAR VERSION:2.0 PRODID:www.example.com X-WR-TIMEZONE:America/Chicago X-PUBLISHED-TTL:P1W BEGIN:VEVENT UID:56bba0729f450 DTSTART;TZID=America/Chicago:20160212T170000 SEQUENCE:0 TRANSP:OPAQUE DTEND;TZID=America/Chicago:20160212T183000 SUMMARY:Beer-o-clock CLASS:PUBLIC DTSTAMP:20160210T144122Z END:VEVENT BEGIN:VTIMEZONE TZID:America/Chicago X-LIC-LOCATION:America/Chicago BEGIN:DAYLIGHT TZNAME:CDT TZOFFSETFROM:-0600 TZOFFSETTO:-0500 DTSTART:19700308T020000 RRULE:FREQ=YEARLY;INTERVAL=1;BYMONTH=3;BYDAY=2SU END:DAYLIGHT BEGIN:STANDARD TZNAME:CST TZOFFSETFROM:-0500 TZOFFSETTO:-0600 DTSTART:19701101T030000 RRULE:FREQ=YEARLY;INTERVAL=1;BYMONTH=11;BYDAY=1SU END:STANDARD END:VTIMEZONE END:VCALENDAR This invite works, but if you open it in a different timezone (e.g. I'm seeing this when I open it from the Pacific timezone) in outlook it doesn't recognize the timezone change. The timezone change is recognized by other apps like mac os Calendar or Google calendar. When I rearrange the calendar file so that the VEVENT definition is after the VTIMEZONE definition it does work in outlook: BEGIN:VCALENDAR VERSION:2.0 PRODID:www.example.com X-WR-TIMEZONE:America/Chicago X-PUBLISHED-TTL:P1W BEGIN:VTIMEZONE TZID:America/Chicago X-LIC-LOCATION:America/Chicago BEGIN:DAYLIGHT TZNAME:CDT TZOFFSETFROM:-0600 TZOFFSETTO:-0500 DTSTART:19700308T020000 RRULE:FREQ=YEARLY;INTERVAL=1;BYMONTH=3;BYDAY=2SU END:DAYLIGHT BEGIN:STANDARD TZNAME:CST TZOFFSETFROM:-0500 TZOFFSETTO:-0600 DTSTART:19701101T030000 RRULE:FREQ=YEARLY;INTERVAL=1;BYMONTH=11;BYDAY=1SU END:STANDARD END:VTIMEZONE BEGIN:VEVENT UID:56bba0729f450 DTSTART;TZID=America/Chicago:20160212T170000 SEQUENCE:0 TRANSP:OPAQUE DTEND;TZID=America/Chicago:20160212T183000 SUMMARY:Beer-o-clock CLASS:PUBLIC DTSTAMP:20160210T144122Z END:VEVENT END:VCALENDAR It seems like this is a parsing error in outlook but I'm not totally sure. I don't know how much control I have over the order in which the ics file is generated without hacking at the vendor code (which I'm hoping not to do). Is this an outlook specific thing or is there something else wrong with the invite definition? A: The iCalendar specifications do not require you to put the VTIMEZONE component at the top. But, of course, people are free to implement the spec however they choose.

Q: componenetDidUpdate() is not being called I am trying to delete a <Table> data. What I am doing is, selecting the a single row of the <Table> and press the Delete button (custom made). and the function for Delete is being fired. The Data is being deleted at the server's end, but the UI is not updated. here is the code: export default class DeleteUserForms extends Component{ constructor(props) { super(props); this.state = {value: 1}; this.data = this.props.selectedValue; this.handleDeletedata=this.handleDeletedata.bind(this); } handleDeletedata(event){ event.preventDefault(); console.log('Data before delete function call'); console.log(this.data); this.props.dispatch(deleteUser(this.data)); // this.props.close(event) } componentWillUpdate(){ console.log('COMPONENT WILL UPDATEEEEEEEEEEEEEEEEE'); this.props.dispatch(getUserRole()) } // componentDidMount(){ // console.log('COMPONENT DID MOUNT'); // // this.props.close(); // } componentDidUpdate(){ console.log('COMPONENT DID UPDATEEEEEEEEEEEEEEEEEEEEE'); // this.props.close(); } render(){ return( <form onSubmit={this.handleDeletedata}> <MuiThemeProvider muiTheme={muiThemedrpdown}> <div> Do you really want to delete the record for {this.props.selectedValue.name}? </div> </MuiThemeProvider> <MuiThemeProvider muiTheme={muiThemebtn}> <div> <RaisedButton label="Yes" primary={true} type="submit" className="btndiv" /> <RaisedButton label="No" primary={true} onClick={this.props.close} className="btndiv" /> </div> </MuiThemeProvider> </form> ); } } Here also I am trying to close a modal after the data has been deleted. but the componentDidUpdate() method is not being called. Please suggest A: It does not refresh, because you assign date in the constructor - date has always the initial value. The constructor is called only once at the beginning, so this.data will always have an initial value this.props.data. Component is not refreshing, because nothing has really changed. try this: this.props.dispatch(deleteUser(this.props.data));

Q: What's the syntax for filtering out records with certain phrases in ElasticSearch The json looks like this { "company": { "type": "SME", "name": "Taylor Corps" }, "contact": { "tel": "5334234234", "name": "Jane Doe" }, "affiliates": { "org": "Taylor Corps" } } image I want to filter out all the people who has "Taylor" in their company.name or affiliates.org. I tried multi_field in a bool filter doesn't seem working in filter. Any advice? Thank you! A: Use following query: { "query": { "query_string": { "fields": [ "company.name" , "affiliates.org" ], "query": "Taylor" } } }

Q: Ext JS 6 - Charts are not found despite including ext-all.js Despite that I included ext-all.js file in my index page; getting error like below when I try this online Guage chart example provided by Sencha http://myapp.com/widget/polar.js?_dc=1436970370848 404 (Not Found) Uncaught Error: [Ext.create] Unrecognized class name / alias: widget.polar A: The charts are in a separated package: Sencha Charts are not included in the Ext JS library by default. In order to include the charts package, simply add “charts” (“sencha-charts” if working with Ext JS 5.x) to the requires block in your Sencha Cmd generated application’s {appRoot}/app.json file. Adding a package name to the requires array directs Cmd to make the package available to your application. https://docs.sencha.com/extjs/5.1/components/introduction_to_charting.html A: "requires": [ "charts" ], This should be uncommented from your app.json

.redactor_box { position: relative; /*border: 1px solid #ddd;*/ overflow: visible; } /*.redactor_box, .redactor_box textarea { background-color: #fff; }*/ body .redactor_air { position: absolute; border: 1px solid #ddd; border-bottom: none; z-index: 10002; } /* Fullscreen */ body .redactor_box_fullscreen { left: 0; position: fixed; overflow: hidden; top: 0; width: 100%; z-index: 2000; } .redactor_box textarea { font-family: Menlo, Monaco, monospace, sans-serif; font-size: 13px; overflow: auto; resize: none; margin: 0; padding: 0; display: block; position: relative; z-index: 1004; outline: none; border: none; width: 100%; } .redactor_editor, .redactor_editor:focus, .redactor_editor div, .redactor_editor p, .redactor_editor ul, .redactor_editor ol, .redactor_editor table, .redactor_editor dl, .redactor_editor blockquote, .redactor_editor pre, .redactor_editor h1, .redactor_editor h2, .redactor_editor h3, .redactor_editor h4, .redactor_editor h5 { font-family: 'Helvetica Neue',Arial,'Liberation Sans',FreeSans,'Hiragino Sans GB',sans-serif,"Microsoft YaHei",微软雅黑,"Microsoft JhengHei",华文细黑,STHeiti,MingLiu; /*font-family: Arial, Helvetica, Verdana, Tahoma, sans-serif !important;*/ } .redactor_editor code, .redactor_editor pre { font-family: Menlo, Monaco, monospace, sans-serif !important; } /*.redactor_editor, .redactor_editor:focus, .redactor_editor div, .redactor_editor p, .redactor_editor ul, .redactor_editor ol, .redactor_editor table, .redactor_editor dl, .redactor_editor blockquote, .redactor_editor pre { font-size: 15px !important; line-height: 1.45em !important; }*/ .redactor_editor, .redactor_editor:focus { position: relative; outline: none; box-shadow: none !important; /*padding: 15px !important;*/ margin: 0 !important; background: none; /*background: #fff !important;*/ overflow: auto; white-space: normal; } .redactor_editor a { /*color: #15c !important;*/ /*text-decoration: underline !important;*/ } .redactor_editor object, .redactor_editor embed, .redactor_editor video, .redactor_editor img { /*width: auto;*/ max-width: 100%; } .redactor_editor video, .redactor_editor img { height: auto; } /*.redactor_editor div, .redactor_editor p, .redactor_editor ul, .redactor_editor ol, .redactor_editor table, .redactor_editor dl, .redactor_editor blockquote, .redactor_editor pre { box-shadow: none !important; background: none !important; margin: 0 !important; margin-bottom: 15px !important; border: none; }*/ .redactor_editor iframe, .redactor_editor object, .redactor_editor hr { margin-bottom: 15px !important; } .redactor_editor blockquote { margin-left: 3em !important; font-style: italic !important; color: #777; } .redactor_editor ul, .redactor_editor ol { padding-left: 2em !important; } .redactor_editor ul ul, .redactor_editor ol ol, .redactor_editor ul ol, .redactor_editor ol ul { border: none; margin: 2px !important; padding: 0 !important; padding-left: 2em !important; } .redactor_editor dl dt { font-weight: bold; } .redactor_editor dd { margin-left: 1em;} .redactor_editor table { border-collapse: collapse; font-size: 1em !important; } .redactor_editor table td { border: 1px solid #ddd; padding: 5px !important; vertical-align: top; } .redactor_editor table thead td { border-bottom: 2px solid #000 !important; font-weight: bold !important; } .redactor_editor code { background-color: #d8d7d7 !important; } .redactor_editor pre { font-size: 90% !important; background: #f8f8f8 !important; border: 1px solid #ddd !important; border-radius: 3px !important; padding: 1em !important; white-space: pre; overflow: auto; } .redactor_editor hr { display: block; height: 1px; border: 0; border-top: 1px solid #ccc; } .redactor_editor h1, .redactor_editor h2, .redactor_editor h3, .redactor_editor h4, .redactor_editor h5 { color: #000; background: none; margin: 0 !important; padding: 0 !important; font-weight: bold; } .redactor_editor h1 { font-size: 36px !important; line-height: 40px !important; margin-bottom: 10px !important; } .redactor_editor h2 { font-size: 30px !important; line-height: 38px !important; margin-bottom: 15px !important; } .redactor_editor h3 { font-size: 24px !important; line-height: 30px !important; margin-bottom: 10px !important; } .redactor_editor h4 { font-size: 18px !important; line-height: 24px !important; margin-bottom: 10px !important; } .redactor_editor h5 { font-size: 1em !important; margin-bottom: 10px !important; } .redactor_editor.redactor_editor_wym { background: #f6f6f6 !important; padding: 5px 15px !important; } .redactor_editor_wym div, .redactor_editor_wym p, .redactor_editor_wym ul, .redactor_editor_wym ol, .redactor_editor_wym table, .redactor_editor_wym dl, .redactor_editor_wym pre, .redactor_editor_wym h1, .redactor_editor_wym h2, .redactor_editor_wym h3, .redactor_editor_wym h4, .redactor_editor_wym h5, .redactor_editor_wym blockquote { background-color: #fff !important; border: 1px solid #e4e4e4 !important; padding: 10px !important; margin: 10px 0 !important; } .redactor_editor_wym ul, .redactor_editor_wym ol { padding-left: 2em !important; } /* TOOLBAR */ .redactor_toolbar { font-family: Helvetica, Arial, Verdana, Tahoma, sans-serif !important; position: relative; left: 0; top: 0; margin: 0 !important; padding: 0 !important; padding-left: 2px !important; line-height: 0 !important; list-style: none !important; font-size: 0; background: #f1f1f1; background: -moz-linear-gradient(top, #f1f1f1 0%, #e2e2e2 100%); background: -webkit-gradient(linear, left top, left bottom, color-stop(0%,#f1f1f1), color-stop(100%,#e2e2e2)); background: -webkit-linear-gradient(top, #f1f1f1 0%,#e2e2e2 100%); background: -o-linear-gradient(top, #f1f1f1 0%,#e2e2e2 100%); background: -ms-linear-gradient(top, #f1f1f1 0%,#e2e2e2 100%); background: linear-gradient(to bottom, #f1f1f1 0%,#e2e2e2 100%); filter: progid:DXImageTransform.Microsoft.gradient( startColorstr='#f1f1f1', endColorstr='#e2e2e2',GradientType=0 ); overflow: hidden !important; height: 32px !important; border-bottom: 1px solid #bbb; } body .redactor_air .redactor_toolbar { padding-right: 2px !important; } .redactor_toolbar li { float: left !important; margin: 0 !important; padding: 3px 1px; padding-right: 0; list-style: none !important; outline: none; } .redactor_toolbar li.redactor_separator { float: left; height: 34px; border-left: 1px solid #d3d3d3; border-right: 1px solid #f1f1f1; padding: 0; margin: 0 2px 0 3px !important; } .redactor_toolbar li a { width: 25px; height: 25px; border: 1px solid transparent; * border: 1px solid #eee; display: block; line-height: 0; font-size: 0; cursor: pointer; zoom: 1; outline: none; text-decoration: none; } .redactor_toolbar li.redactor_btn_right { float: none; float: right !important; } .redactor_toolbar li a { display: block; text-indent: -9999px; background-image: url(data:image/png;base64,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); background-repeat: no-repeat; background-position: 0; } @media all and (-webkit-min-device-pixel-ratio: 1.5) { .redactor_toolbar li a { background-image: url(data:image/png;base64,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); background-size: auto 25px; } } .redactor_toolbar li a:hover { border-color: #98a6ba; background-color: #dde4ef; outline: none; } .redactor_toolbar li a:active, .redactor_toolbar li a.redactor_act { border-color: #b5b5b5; background-color: #ddd; outline: none; } /* BUTTONS step 25px */ body .redactor_toolbar li a.redactor_btn_html { background-position: 0px; } body .redactor_toolbar li a.redactor_btn_formatting { background-position: -25px; } body .redactor_toolbar li a.redactor_btn_bold { background-position: -50px; } body .redactor_toolbar li a.redactor_btn_italic { background-position: -75px; } body .redactor_toolbar li a.redactor_btn_deleted { background-position: -500px; } body .redactor_toolbar li a.redactor_btn_unorderedlist { background-position: -100px; } body .redactor_toolbar li a.redactor_btn_orderedlist { background-position: -125px; } body .redactor_toolbar li a.redactor_btn_outdent { background-position: -150px; } body .redactor_toolbar li a.redactor_btn_indent { background-position: -175px; } body .redactor_toolbar li a.redactor_btn_image { background-position: -200px; } body .redactor_toolbar li a.redactor_btn_video { background-position: -225px; } body .redactor_toolbar li a.redactor_btn_file { background-position: -250px; } body .redactor_toolbar li a.redactor_btn_table { background-position: -275px; } body .redactor_toolbar li a.redactor_btn_link { background-position: -300px; } body .redactor_toolbar li a.redactor_btn_fontcolor { background-position: -325px; } body .redactor_toolbar li a.redactor_btn_backcolor { background-position: -350px; } body .redactor_toolbar li a.redactor_btn_alignleft { background-position: -375px; } body .redactor_toolbar li a.redactor_btn_aligncenter { background-position: -400px; } body .redactor_toolbar li a.redactor_btn_alignright { background-position: -425px; } body .redactor_toolbar li a.redactor_btn_justify { background-position: -450px; } body .redactor_toolbar li a.redactor_btn_horizontalrule { background-position: -475px; } body .redactor_toolbar li a.redactor_btn_underline { background-position: -525px; } body .redactor_toolbar li a.redactor_btn_fullscreen { background-position: -550px; } body .redactor_toolbar li a.redactor_btn_normalscreen { background-position: -575px; } body .redactor_toolbar li a.redactor_btn_clips { background-position: -600px; } body .redactor_toolbar li a.redactor_btn_alignment { background-position: -625px; } /* Toolbar classes */ .redactor_format_blockquote { font-style: italic; color: #666 !important; padding-left: 10px; } .redactor_format_pre { font-family: monospace, sans-serif; } .redactor_format_h1, .redactor_format_h2, .redactor_format_h3, .redactor_format_h4 { font-weight: bold; } .redactor_format_h1 { font-size: 30px; line-height: 36px; } .redactor_format_h2 { font-size: 24px; line-height: 36px; } .redactor_format_h3 { font-size: 20px; line-height: 30px; } .redactor_format_h4 { font-size: 16px; line-height: 26px; } /* DROPDOWN */ .redactor_dropdown { font-family: Helvetica, Arial, Verdana, Tahoma, sans-serif; top: 28px; left: 0; z-index: 2004; position: absolute; width: 200px; background-color: #fff; border: 1px solid #ccc; font-size: 13px; -webkit-box-shadow: 0 2px 4px #ccc; -moz-box-shadow: 0 2px 4px #ccc; box-shadow: 0 2px 4px #ccc; line-height: 21px; padding: 10px; } .redactor_separator_drop { border-top: 1px solid #ddd; padding: 0 !important; line-height: 0; font-size: 0; } .redactor_dropdown a { display: block; color: #000; padding: 3px 5px; text-decoration: none; } .redactor_dropdown a:hover { color: #444 !important; text-decoration: none; background-color: #dde4ef; } /* ColorPicker */ .redactor_color_link { padding: 0 !important; width: 15px !important; height: 15px !important; box-shadow: 0 1px 2px rgba(0, 0, 0, .2) inset !important; border-radius: 4px !important; float: left !important; border: 2px solid #fff !important; font-size: 0; } .redactor_color_none { font-size: 11px; } /* MODAL */ #redactor_modal_overlay { position: fixed; margin: auto; top: 0; left: 0; width: 100%; height: 100%; z-index: 50000; -ms-filter:"progid:DXImageTransform.Microsoft.Alpha(Opacity=50)"; filter:alpha(opacity=50); opacity: 0.50; background-color: #333 !important; } #redactor_modal { background: #f7f7f7; background: -moz-linear-gradient(top, #f7f7f7 0%, #e2e2e2 100%); background: -webkit-gradient(linear, left top, left bottom, color-stop(0%,#f7f7f7), color-stop(100%,#e2e2e2)); background: -webkit-linear-gradient(top, #f7f7f7 0%,#e2e2e2 100%); background: -o-linear-gradient(top, #f7f7f7 0%,#e2e2e2 100%); background: -ms-linear-gradient(top, #f7f7f7 0%,#e2e2e2 100%); background: linear-gradient(to bottom, #f7f7f7 0%,#e2e2e2 100%); filter: progid:DXImageTransform.Microsoft.gradient( startColorstr='#f7f7f7', endColorstr='#e2e2e2',GradientType=0 ); text-shadow: 0 1px 0 #fff; padding: 0; position: fixed; top: 50%; left: 50%; box-shadow: 0px 5px 60px #000; border-radius: 3px; z-index: 50001; font-family: Helvetica, Arial, Verdana, Tahoma, sans-serif; font-size: 12px !important; color: #000; } #redactor_modal_header { padding: 11px 30px 0 15px; font-size: 12px; border-radius: 3px 3px 0 0; font-weight: bold; } #redactor_modal_content { padding: 20px 30px; } #redactor_modal_close { position: absolute; right: 5px; top: 5px; font-size: 20px; width: 20px; height: 20px; color: #777; cursor: pointer; } #redactor_modal_close:hover { color: #000; } #redactor_modal label { margin: 10px 0 3px 0 !important; padding: 0 !important; float: none !important; display: block !important; } #redactor_modal textarea { margin-top: 4px; display: block; } .redactor_input { width: 99%; font-size: 14px; } .redactor_modal_box { height: 350px; overflow: auto; margin-bottom: 10px; } #redactor_image_box { height: 270px; overflow: auto; margin-bottom: 10px; } #redactor_image_box_select { display: block; width: 200px; margin-bottom: 15px; } #redactor_image_box img { margin-right: 10px; margin-bottom: 10px; cursor: pointer; max-width: 100px; } #redactor_tabs { margin-bottom: 18px; } #redactor_tabs a { display: inline-block; border: 1px solid #d2d2d2; padding: 4px 14px; font-size: 12px; background-color: #fff; text-decoration: none; color: #000; line-height: 1; border-radius: 10px; margin-right: 5px; } #redactor_tabs a:hover, #redactor_tabs a.redactor_tabs_act { background-color: #ddd; padding: 5px 15px; box-shadow: 0 1px 2px rgba(0, 0, 0, .4) inset; border: none; text-shadow: 0 1px 0 #eee; color: #777 !important; text-decoration: none !important; } #redactor_modal_footer { padding: 9px 30px 20px 30px; border-radius: 0 0 3px 3px; text-align: right; } #redactor_modal input[type="radio"], #redactor_modal input[type="checkbox"] { position: relative; top: -1px; } #redactor_modal input[type="text"], #redactor_modal input[type="password"], #redactor_modal input[type="email"], #redactor_modal textarea { position: relative; z-index: 2; font-family: Helvetica, Arial, Tahoma, sans-serif; height: 23px; border: 1px solid #ccc; margin: 0; padding: 1px 2px; background-color: white; color: #333; font-size: 13px; line-height: 1; border-radius: 1px; box-shadow: 0 1px 2px rgba(0, 0, 0, 0.2) inset; -webkit-transition: border 0.3s ease-in; -moz-transition: border 0.3s ease-in; -ms-transition: border 0.3s ease-in; -o-transition: border 0.3s ease-in; transition: border 0.3s ease-in; } #redactor_modal textarea { line-height: 1.4em; } #redactor_modal input:focus, #redactor_modal textarea:focus { outline: none; border-color: #5ca9e4; box-shadow: 0 0 0 2px rgba(70, 161, 231, 0.3), 0 1px 2px rgba(0, 0, 0, 0.2) inset; } .redactor_modal_btn { margin-left: 8px; position: relative; cursor: pointer; outline: none; display: inline-block; text-align: center; text-decoration: none; font-family: Helvetica, Arial, Verdana, Tahoma, sans-serif; line-height: 1; font-size: 12px; font-weight: normal; padding: 6px 16px 5px 16px; border-radius: 4px; background-color: #f3f3f3; background-image: -moz-linear-gradient(top, #ffffff, #e1e1e1); background-image: -ms-linear-gradient(top, #ffffff, #e1e1e1); background-image: -webkit-gradient(linear, 0 0, 0 100%, from(#ffffff), to(#e1e1e1)); background-image: -webkit-linear-gradient(top, #ffffff, #e1e1e1); background-image: -o-linear-gradient(top, #ffffff, #e1e1e1); background-image: linear-gradient(top, #ffffff, #e1e1e1); filter: progid:DXImageTransform.Microsoft.gradient(startColorstr='#ffffff', endColorstr='#e1e1e1', GradientType=0); border: 1px solid #ccc; border-bottom-color: #aaa; box-shadow: 0 1px 1px rgba(0, 0, 0, .1); text-shadow: 0 1px 0px #ffffff; color: #000; } .redactor_modal_btn:hover { color: #555; } .redactor_modal_btn:hover { filter: none; background: none; background: #f3f3f3; text-shadow: 0 1px 0px rgba(255, 255, 255, 0.8); text-decoration: none; } /* Drag and Drop Area */ .redactor_droparea { position: relative; width: 100%; margin: auto; margin-bottom: 5px; } .redactor_droparea .redactor_dropareabox { z-index: 1; position: relative; text-align: center; width: 99%; background-color: #fff; padding: 60px 0; border: 2px dashed #bbb; } .redactor_droparea .redactor_dropareabox, .redactor_dropalternative { color: #555; font-size: 12px; } .redactor_dropalternative { margin: 4px 0 2px 0; } .redactor_dropareabox.hover { background: #efe3b8; border-color: #aaa; } .redactor_dropareabox.error { background: #f7e5e5; border-color: #dcc3c3; } .redactor_dropareabox.drop { background: #f4f4ee; border-color: #e0e5d6; } /*Biu curtom fixed*/ #post_form_1 .input-xxlarge{width: 700px;} #post_form_1 .input-mlarge{width: 400px;} .new_post_template_4 #post_form_1 .post_caption textarea.input-xxlarge{width: 350px;} .redactor_box{margin: 0 auto;display: inline-block;} .redactor_editor{width: 700px;text-align: left;min-height: 200px;} .redactor_editor h1 {text-align: left;margin-top: 10px!important;} .redactor_editor ul li{list-style: disc;} .redactor_editor ol li{list-style: decimal;} .new_post_template_5 #post_form_1 .input-xxlarge{width: 400px;} .new_post_template_5 .redactor_box{display: block;width: 400px;margin-left: 0;} .new_post_template_5 .redactor_editor{width: 400px;} .new_post_template_5 .post_article{position: relative;} .new_post_template_5 .post_article .Validform_checktip{top: 0;left: 410px;} /*片段名称*/ .new_post_template_1 .post_name input, .new_post_template_2 .post_name input, .new_post_template_5 .post_name input{ height: auto; border: none; box-shadow: none; border-radius: 0; background:#fafaf5; color: #303239; font-size: 34px; font-weight: 700; line-height: 1.1; transition:none; } .new_post_template_3 .post_name input{ height: auto; border-radius: 0; border: none; box-shadow: none; background: #fff; font-size: 22px; color: #333332; } .post_name input:focus{ border: none; box-shadow: none; background:#f7f7f2; } .new_post_template_3 .post_name input:focus{ background: #fff; color: #332; } /*片段摘要*/ .post_caption textarea{ border: none; box-shadow: none; background:#fafaf5; border-radius: 0; color: #9D9D9D; font-size: 24px; line-height: 36px; } .post_caption textarea:focus{ background: #f7f7f2; } .new_post_template_4 .post_caption textarea:focus{ background: rgba(0, 0, 0, 0.4); } .redactor_editor{ /*border: 2px dashed #ddd;*/ background: #fafaf5; padding:4px 6px; color: #444444; font-size: 18px; line-height: 30px; cursor: text; } .redactor_editor:focus{ border: none; background: #f7f7f2; } body .redactor_air{border: none;box-shadow: 0 1px 3px rgba(0,0,0,0.2);overflow: hidden;border-radius: 5px;} .redactor_toolbar{background: rgba(255,255,255,0.95);border: none;border-radius: 5px;height: auto!important;} body .redactor_air .redactor_toolbar {padding: 0 5px 0 4px!important} .redactor_toolbar li{padding: 5px 0 5px 3px;} .redactor_toolbar li a:hover { background-color: #58AD69; border-color: #58AD69; } .redactor_toolbar li.redactor_separator { border-left: 1px solid #e3e3e3; border-right: 1px solid #fff; float: left; height: 37px; margin: 0 2px 0 5px !important; padding: 0; }

Q: Simple Markov Chain: Random Walk on $\mathbb{Z}$ We are given a random walk on $\mathbb{Z}$, where $p_{i, i+1}= p < \frac{1}{2}$ and $p_{i,i-1}=1-p > \frac{1}{2}$, starting at $0$. Now we have to compute the probability that we eventually reach $k \in \mathbb{N}$. How could one solve that? For the recurrence equation $d_i=p d_{i+1} + (1-p) d_{i-1}$ I have no base cases (except $d_k=1$) and computing $P[\text{eventually reaching k}]=\sum_{i=1}^{\infty} P[\text{ reaching k in step i}]$ seems to be very nasty. So do you have a hint how to solve this? A: Consider some nonnegative integers $i$ and $j$. To reach $i+j$ starting from $0$, one must first reach $i$ starting from $0$ then reach $i+j$ starting from $i$. The probability of the first event is $d_i$. By the Markov property and the invariance of the dynamics by the translations of $\mathbb Z$, the property of the second event conditionally on the first is $d_j$. Thus $d_{i+j}=d_id_j$ for every nonnegative integers $i$ and $j$, with $d_0=1$. Using that $d_i\lt1$ for every $i\geqslant1$ since the random walk has a negative drift, and the identity in your post, this suffices to show that $d_i=r^i$ for every $i\geqslant1$, where $r=$ $____$.

Prolyl endopeptidase purified from granulomatous inflammation in mice. Activity of prolyl endopeptidase (EC 3.4.21.26) which hydrolyses the Pro7-Phe8 bond in angiotensin II has been found to elevate in experimentally produced granulomatous inflammation in liver and skin. We purified the enzyme 1,536-fold by 6 steps from murine hepatic granulomas. The purified enzyme has a molecular weight of 79 kDa and physicochemical properties equivalent to those previously reported for prolyl endopeptidase purified from other sources. By HPLC analysis, the cleavage of Phe8-Leu10 and Phe8 from angiotensin I and II, respectively, was detected and quantified. Monospecific IgG was prepared from serum of rabbits injected with purified enzyme. Concentration of the enzyme was immunohistochemically detected in cells which form granulomatous organization, but not in inflammatory cells surrounding the foci. The antibody, however, cross reacted with the enzyme in adjacent liver cells and weakly stained their cytoplasm. The findings indicate that this enzyme, in addition to angiotensin converting enzyme, may serve as a useful biochemical marker for granulomatous tissue reactions.

Cardiac overexpression of the norepinephrine transporter uptake-1 results in marked improvement of heart failure. A hyperadrenergic state is one of the key features of human and experimental heart failure. Decreased densities and activities of the presynaptic neuronal norepinephrine (NE) transporter uptake-1 occur both in patients and animal models. It is currently unclear to what extent the reduction of uptake-1 contributes to the deterioration of heart failure. Therefore, we investigated the effects of myocardial overexpression of uptake-1 in both nonfailing rabbit hearts and in an animal model of heart failure. Heart failure was induced in rabbits by rapid ventricular pacing. Adenoviral gene transfer was used to overexpress uptake-1 in the myocardium. Uptake-1 overexpression led to increased NE uptake capacity into the myocardium. In contrast, systemic plasma NE levels in uptake-1-overexpressing failing rabbits (uptake-1-CHF) did not differ from controls. Downregulation of SERCA-2 and beta-adrenergic receptors in the failing myocardium was significantly reversed after uptake-1 overexpression. Uptake-1 overexpression significantly improved left ventricular (LV) diameters (LV end-diastolic diameter: in GCP-overexpressing failing rabbits (GFP-CHF), 17.4+/-0.4 mm; in uptake-1-CHF rabbits, 15.6+/-0.6 mm) and systolic contractility (fractional shortening: GFP-CHF, 20.7+/-0.6%; uptake-1-CHF, 27.3+/-0.7%), as assessed by echocardiography at the end of the heart failure protocol. Intraventricular tip catheter measurements revealed enhanced contractile reserve (dP/dt max with isoproterenol 1.0 microg/kg: GFP-CHF, 6964+/-230 mm Hg/sec; uptake-1-CHF, 7660+/-315 mm Hg/sec) and LV relaxation (dP/dt min with isoproterenol 1.0 microg/kg: GFP-CHF: -3960+/-260 mm Hg/sec; uptake-1-CHF, -4910+/-490 mm Hg/sec). End-diastolic filling pressures (GFP-CHF, 8.5+/-1.2 mm Hg; uptake-1-CHF, 5.6+/-0.7 mm Hg) tended to be lower in uptake-1 overexpressing animals. In summary, local overexpression of uptake-1 in the myocardium results in marked structural and functional improvement of heart failure, thus underlining the importance of uptake-1 as a key protein in heart failure.

The invention relates to coded signals that represent pictures using fewer bits than conventional picture signals and, in particular, to a transcoding method and transcoder that transcodes coded object-based picture signals to coded block-based picture signals to allow a conventional block-based picture signal decoder to decode the coded object-based picture signals. Communication using picture signals that electronically represent still and moving pictures is becoming ubiquitous, together with the use of signal coding to increase the efficiency with which such signals can be transmitted and stored. Signal coding is crucial to overcome the many limitations that exist on transmission bandwidth and storage capacity. Most of the popular and successful conventional picture signal coding techniques, such as those known as JPEG, MPEG-1, MPEG-2, ITU H.261 and ITU H.263, code the original picture signal by subjecting it to block-based processing. In block-based processing, each picture is expressed as an array of picture elements (pixels), e.g., an array of 640xc3x97480 pixels, each of which has a pixel value. The pixel values collectively constitute the picture signal. The picture is divided into regularly-sized and located square or rectangular blocks of pixels. Processing, such as block discrete cosine transforms (block-DCT), block-based motion estimation and block-based motion compensation is then individually applied to the corresponding blocks of pixel values to code the picture signal. The picture is divided into blocks regardless of the sizes and shapes of the objects represented by the picture. Recently, techniques have been developed for generating object-based picture signals that represent the picture as a number of objects arranged to form a scene. Techniques have also been proposed for coding such object-based picture signals, the foremost example of which is that embodied in the emerging MPEG-4 standard. In an object-based picture signal, a picture, which may be a single still picture, or one of a group of sequential still pictures constituting a moving picture, is decomposed into objects having arbitrary shapes, unlike the regularly-sized and located blocks of current block-based representations. Each object is represented by a portion of the picture signal. This technique provides a more natural decomposition of the picture signal that may enable a number of new functionalities, such as user interaction with the objects in the picture, greater content-creation flexibility, and potentially improved coding efficiency and fidelity. These advantages of representing pictures using object-based picture signals is likely to especially appeal to content creators. Object-based picture signals require object-based coding techniques such as MPEG-4 to code, manipulate, and distribute them. However, an MPEG-4 decoder, which is required to decode a coded object-based picture signal, is inherently more complex than conventional block-based MPEG-1 or MPEG-2 decoders. Moreover, the spread of DVD, Digital TV and HDTV has put MPEG-2 decoders into widespread use. JPEG still picture decoders are also widely used. Therefore, for users who already have a JPEG or MPEG-2 decoder, and who do not want or cannot afford the additional functionalities offered by an object-based picture signal, the need arises to transcode the MPEG-4 object-based picture signal to an MPEG-2 block-based picture signal. A similar need exists with respect to still pictures. Moreover, while program content may be developed using object-based picture signals, it may be desirable to distribute the object-based content to people who only have conventional block-based decoders, such as the MPEG-2 decoders used in DVD, satellite and terrestrial digital television. Consequently, a need exists to be able to transcode coded object-based picture signals to coded block-based picture signals that are compatible with the standard decoders of such block-based coding techniques as JPEG, MPEG-1, MPEG-2, H.261 and H.263. FIG. 1 is a block diagram of a conventional transcoder 10 capable of transcoding an MPEG-4 or similar coded object-based picture signal to an MPEG-2 or similar coded block-based picture signal. The system is composed of the MPEG-4 decoder 12 and the MPEG-2 encoder 14. The output 18 of the MPEG-4 decoder is connected to the input 20 of the MPEG-2 encoder. The output 22 of the MPEG-2 decoder provides a coded block-based picture signal that is compliant with the standard MPEG-2 decoder. The input 16 of the MPEG-4 decoder receives a coded object-based picture signal that is compliant with the MPEG-4 standard decoder. The MPEG-4 decoder decodes the coded object-based picture signal to generate a conventional picture signal, which it feeds to its output 18. The conventional picture signal may be a set of RGB signals, a set of YIQ or YUV signals or some other suitable form of conventional picture signal. The MPEG-2 encoder receives the conventional picture signal at its input 20 and applies conventional block-based coding thereto. The MPEG-2 encoder delivers a coded block-based picture signal that is compliant with the MPEG-2 standard decoder to its output 22. The conventional transcoder 10, although simple in concept, is complex in execution. The coding processing performed by the MPEG-2 encoder is complex and requires substantial computational resources to perform in real time. Furthermore, the decoding and subsequent encoding performed by the transcoder 10 often degrades the quality of the picture. An alternative approach is to attempt to perform the transcoding in the coded domain. This would eliminate the need to perform at least part of the re-encoding. Transcoding in the coded domain has the potential to reduce significantly the processing complexity, and also to eliminate partially or completely the generation loss suffered by conventional transcoding. Some approaches to transcoding conventional block-based picture signals in the coded domain are described by S. F. Chang and D. Messerschmitt in Manipulation and Compositing of MC-DCT Compressed Video, 13 IEEE J. ON SELECTED AREAS IN COMMUNICATIONS (1995 January); B. Natarajan and B. Vasudev in A Fast Approximate Algorithm for Scaling Down Digital Images in the DCT Domain, Proc. IEEE INTL. Conf. on Image Processing (WASHINGTON D.C.) (1995 October); N. Merhav and B. Vasudev, Fast Algorithms for DCT-Domain Image Down Sampling and for Inverse Motion Compensation, 7 IEEE Trans. on Circuits and System for Video Technology, 468-475 (1997 June); B. Shen and I. Ishwar in Block-based Manipulations on Transform-Compressed Images and Videos, 6 MULTIMEDIA SYSTEMS (1998 March); S. Wee and B. Vasudev in Splicing MPEG Video Streams in the Compressed Domain, Proc. IEEE INTL. Conf. on Multimedia Signal Processing (PRINCETON, N.J.) (1997 June). However, none of the above-cited references describes a coded domain transcoder capable of transcoding a coded object-based picture signal to a coded block-based picture signal. What is needed, therefore, is a coded-domain transcoder capable of transcoding in real-time a coded object-based picture signal representing a still or moving picture into a corresponding coded block-bas based picture signal. What is also needed is such a coded-domain transcoder having modest and affordable hardware requirements. The invention provides a transcoder for transcoding a coded object-based picture signal that represents a picture to a coded block-based picture signal that also represents the picture. The coded object-based picture signal may be an MPEG-4 picture signal, for example, and the coded block-based picture signal may be an MPEG-2 picture signal, for example. The transcoder comprises a culling module, a picture composer and a partial encoder. The culling module receives the coded object-based picture signal and culls signal portions from the coded object-based picture signal to generate a culled object-based picture signal. The signal portions culled are those that represent objects not visible in the picture. The picture composer receives the culled object-based picture signal, partially decodes selected portions of the culled object-based picture signal and generates from them blocks of a partially-coded block-based picture signal in which the blocks have different coding states. The partial encoder receives the partially-coded block-based picture signal and encodes the blocks of the partially-coded block-based picture signal to generate the coded block-based picture signal in which the blocks have a uniform coding state. The coded block-based picture signal is capable of being decoded by a conventional block-based decoder. The culling module may include an object culling module that culls, from the coded object-based picture signal, signal portions that represent objects that are not present in the picture and signal portions that represent objects that are present in the picture but are hidden. The object-based picture signal may include a scene descriptor that describes the arrangement of the objects in the picture and may additionally include a coded shape descriptor for each of the objects. The object culling module may use the scene descriptor to identify the signal portions that represent the objects not present in the picture and may decode the coded shape descriptors of the objects identified as being present in the picture to identify the signal portions that represent the objects that are present in the picture, but are hidden. The object-based picture signal may additionally include, for each of the objects, an object descriptor comprising a coded amplitude descriptor including interior tiles and boundary tiles. The culling module may additionally include a tile culling module that culls, from the object-based picture signal, signal portions that represent interior tiles and boundary tiles that are hidden in the picture. The culled object-based picture signal may include a culled amplitude descriptor for each object visible in the picture, and the picture composer may include a tile-oriented picture composition module, a shift, mask and merge module, processing modules and a processing selection module. The culled amplitude descriptor comprises tiles representing portions of the object visible in the picture. The tile-oriented picture composition module receives the culled object-based picture signal and identifies, for each tile of the culled amplitude descriptors, at least one block of the partially-coded block-based picture signal to which the tile contributes. The shift, mask and merge module calculates shift, mask and merge parameters for each tile. The processing modules are each capable of receiving the tile or tiles contributing to each block of the partially-coded block-based picture signal and of decoding the tile or tiles to the extent that allows the block-generating processing defined by the shift, mask and merge parameters to be applied to them. The processing modules are also capable of applying the block-generating processing defined by the respective shift, mask and merge parameters to the tile or tiles to generate the block. The processing modules are each capable of decoding the tile or tiles contributing to the block to a coding state that differs among the processing modules. The processing selection module selects one of the processing modules to generate the block of the partially-coded block-based picture signal and, hence, selects the coding state in which the block is generated. Alternatively, the culled object-based picture signal may include an amplitude descriptor for each object visible in the picture and the picture composer may include a block-oriented picture composition module, a shift, mask and merge module, processing modules and a processing selection module. Each amplitude descriptor comprises tiles. The block-oriented picture composition module receives the culled object-based picture signal and identifies, for each block of the partially-coded picture signal, the tile or tiles of the culled object-based picture signal that contribute to the block. The shift, mask and merge module calculates shift, mask and merge parameters for tile that contributes to the block. The processing modules are each capable of receiving the tile or tiles that contribute to each block of the partially-coded block-based picture signal and of partially decoding the tile or tiles and applying thereto the respective shift, mask and merge parameters to generate the block. The processing modules are each capable of decoding the tile or tiles contributing to the block to a coding state that differs among the processing modules. The processing selection module selects one of the processing modules to generate the block of the partially-coded block-based picture signal, and, hence, the coding state in which the block is generated. The invention also provides a method for transcoding a coded object-based picture signal representing a picture to a coded block-based picture signal representing the picture. In the method, signal portions that represent objects not visible in the picture are culled from the coded object-based picture signal to generate a culled object-based picture signal. Portions of the culled object-based picture signal are partially decoded and from them are generated blocks of a partially-coded block-based picture signal in which the blocks have different coding states. Finally, the blocks of the partially-coded block-based picture signal are re-encoded to generate the coded block-based picture signal in which the blocks have a uniform coding state. Finally, the invention provides a computer-readable medium in which is fixed a computer program that instructs a computer to perform a transcoding operation in which a coded object-based picture signal representing a picture is transcoded to a coded block-based picture signal representing the picture. In the transcoding operation, signal portions that represent objects not visible in the picture are culled from the coded object-based picture signal to generate a culled object-based picture signal. Portions of the culled object-based picture signal are partially decoded and from them are generated blocks of a partially-coded block-based picture signal in which the blocks have different coding states. Finally, the blocks of the partially-coded block-based picture signal are re-encoded to generate the coded block-based picture signal in which the blocks have a uniform coding state. Culling the signal portions that represent objects not visible in the picture may include culling signal portions that represent objects that are not present in the picture and culling signal portions that represent objects that are present in the picture, but are hidden. The object-based picture signal may include a scene descriptor that describes an arrangement of the objects in the picture and may additionally include a coded shape descriptor for each object. Culling the signal portions that represent objects that are not present in the picture may include identifying, using the scene descriptor, the signal portions that represent the objects not present in the picture, and decoding the coded shape descriptors of the objects that the identifying operation identifies as present in the picture to generate respective shape descriptors. In culling the signal portions that represent objects that are present in the picture, but are hidden, the shape descriptors are used to identify the signal portions that represent the objects that are present in the picture, but are hidden. The object-based picture signal may include an object descriptor for each object. The object descriptor comprises a coded amplitude descriptor including interior tiles and boundary tiles. Culling the signal portions that is represent objects that are present in the picture, but are hidden, may include culling, from the object-based picture signal, signal portions that represent interior tiles and boundary tiles that are hidden in the picture. The culled object-based picture signal may include a culled amplitude descriptor for each object visible in the picture. The culled amplitude descriptor for each object comprises tiles that represent the portions of the object that are visible in the picture. In this case, in partially decoding portions of the culled object-based picture signal and generating from them the blocks of the partially-coded block-based picture signal, the at least one block of the partially-coded block-based picture signal to which each tile of the culled amplitude descriptors contributes is identified. Shift, mask and merge parameters are calculated for each tile. One of a predetermined number of coding states in which to generate each block of the partially-coded block-based picture signal is selected as a selected coding state. Finally, the tile or tiles that contribute to each block of the partially-coded block-based picture signal are decoded to the selected coding state and the block-generating processing defined by the respective shift, mask and merge parameters is applied to the tile or tiles in the selected coding state to generate the block in the selected coding state. Alternatively, the culled object-based picture signal may include an amplitude descriptor for each object visible in the picture. The amplitude descriptor comprises tiles. In partially decoding selected portions of the culled object-based picture signal and generating from them the blocks of the partially-coded block-based picture signal, for each block of the partially-coded picture signal, the tile or tiles of the culled object-based picture signal that contribute to the block are identified. Shift, mask and merge parameters are calculated for each of the tile or tiles that contribute to the block. One of a predetermined number of coding states in which to generate each block of the partially-coded block-based picture signal is selected as a selected coding state. Finally, the tile or tiles contributing to the block of the partially-coded block-based picture signal are decoded to the selected coding state and the block-generating processing defined by the respective shift, mask and merge parameters is applied to the tile or tiles in the selected coding state to generate the block in the selected coding state. The transcoder and transcoding method according to the invention and the transcoding program fixed in the computer-readable medium according to the invention cull portions of the coded object-based picture signal that represent objects that are not visible in the picture before generating the coded block-based picture signal. Compared with conventional transcoders, transcoding methods and transcoding programs, this reduces the processing resources required to process the coded object-based picture signal to generate the coded block-based picture signal, or enables other constraints, such as processing time, to be met more easily since the culled portions of the object-based picture signal are not processed further. Moreover, the transcoder, transcoding method and transcoding program according to the invention process the culled object-based picture signal to generate at least a fraction of the blocks of the coded block-based picture signal in a partially-coded state. Compared with conventional transcoders, transcoding methods and transcoding programs, this further reduces the processing resources required to generate the coded block-based picture signal, or enables other constraints, such as processing time, to be met even more easily. The transcoder, transcoding method and transcoding program according to the invention perform less decoding of the coded object-based picture signal, and perform less encoding to generate the coded block-based picture signal. Moreover, the reduced decoding and encoding applied to the coded object-based picture signal preserve more of the original encoding of the coded object-based picture signal in the block-based picture signal. This reduces the generational quality loss compared with conventional transcoders, transcoding methods and transcoding programs.

package catdata; import java.util.List; import java.util.Map; public interface Raw { public Map<String, List<InteriorLabel<Object>>> raw(); public default int find(String section, Object o) { for (InteriorLabel<Object> il : raw().get(section)) { if (il.s.equals(o)) { return il.loc; } } throw new RuntimeException("For section " + section + ", cannot find " + o); } }

Q: Dynamically created HTML table row is not working fine I have a Select drop-down field So on change of which I am creating a HTML table row which is fully dynamic What I am doing is When user changes drop-down option creating Html table row in which first column i.e ItemName is autocomplete, user can type and select and on focus out some calculation is there here I have two drop-down so when user select supplier 1 loading JSON data i.e tableData , if user selects Supplier 2 then working on tabledata1 here I have to define two JSON data in my code I am using Ajax on change event So when i selects Supplier 1 firstly what I am doing is removing if there is any row present using $(tbody).empty and then a row is populated so in ItemName field I am doing autocomplete and it is working fine Issue is - when I want to change supplier and and now I have selected supplier 2 and deleted the previous row which is of Supplier 1, and when I type in autocomplete field and on focus out it says value is not defined - I don't know what I am doing wrong To check the error selects Supplier 1 and enter 333 and selects from drop-down it will populate some thing in corresponding field Then again change the drop-down from Supplier 1 to Supplier 2 and type white it will show suggestion and on selecting that press tab to focus out there you will find the error var tableData = { "ALMOND CHBAR~2402": { "itemName": "ALMOND CHBAR", "itemCode": "2402", "costPrice": 20.0, "gstPercentage": 14.5, "mrp": 30.0 }, "A BR SB EX~333": { "itemName": "A BR SB EX", "itemCode": "333", "costPrice": 1.0, "gstPercentage": 0.0, "mrp": 1.0 } } var tableData1 = { "White rice~1001": { "itemName": "White rice", "itemCode": "1001", "costPrice": 50.0, "gstPercentage": 5, "mrp": 65.0 }, "Brown rice~333": { "itemName": "Brown rice", "itemCode": "1002", "costPrice": 90, "gstPercentage": 5.0, "mrp": 110 } } $("#supplierInput").on("change", function(e) { $("tbody").empty(); if (this.value == 'Supplier 1') { populateData(tableData) } else { populateData(tableData1) } }); function populateData(data) { var autoCompleteData = Object.keys(data); function rowappend(tbody) { const markup = `<tr> <td> <input type="text" class="form-control commanChange" id="itemNametd" name="itemNametd"> </td> <td><input type="text" name="itemCodetd" id="itemCodetd" class="form-control commantd" readonly="readonly"></td> <td><input type="text" name="mrptd" id="mrptd" class="form-control commantd" readonly="readonly"></td> <td><input type="text" name="purRatetd" id="purRatetd" class="form-control commantd"></td> <td> <input type="tel" id="unitQtytd"class="form-control commanChange" name="unitQtytd"> </td> <td> <input type="tel" id="discPercentagetd"class="form-control commanChange" name="discPercentagetd" > </td> <td><input type="text" name="discAmttd" id="discAmttd" class="form-control commantd" readonly="readonly"></td> <td><input type="text" name="gstPercentagetd" id="gstPercentagetd" class="form-control commantd" readonly="readonly"></td> <td><input type="text" name="gstAmttd" id="gstAmttd" class="form-control commantd" readonly="readonly"></td> <td><input type="text" name="totalAmttd" id="totalAmttd" class="form-control commantd" readonly="readonly"></td> <td style="background-color: white;border: 1px white"><i class="fas fa-times fa-2x remove-btn"></i></td> </tr>` $(tbody).append(markup); setTimeout(() => $("[name=itemNametd]", tbody).last().focus(), 100); $("[name=itemNametd]", tbody).last().autocomplete({ source: autoCompleteData }); } rowappend($('tbody', '#tableInvoice')) function getValues(row) { const search = ($('[name=itemNametd]', row).val()).toString() console.log("search : " + search) const value = data[search]; // this one is causing issue CostPrice = value.costPrice; if (value) { $(row).find("[name=itemCodetd]").val(value.itemCode); $(row).find("[name=mrptd]").val(value.mrp); $(row).find("[name=purRatetd]").val(CostPrice); $(row).find("[name=gstPercentagetd]").val(value.gstPercentage); } } $(document).on('focusout', (e) => { const row = e.target.parentElement.parentElement if (e.target.matches("[name=itemNametd]")) { getValues(e.target.parentElement.parentElement) $("[name=purRatetd]").focus(); } }); $(document).keypress(function(event) { const row = event.target.parentElement.parentElement var keycode = event.keyCode || event.which; if (keycode == '13') { if (!$(event.target).val()) { e.preventDefault(); return; } if (event.target.matches('[name=discPercentagetd]')) { if ($(row).parent().find('tr').length - $(row).index() === 1) { rowappend(event.target.parentElement.parentElement.parentElement) } } } }); } <script src="https://cdnjs.cloudflare.com/ajax/libs/jquery/3.3.1/jquery.min.js"></script> <link href="https://stackpath.bootstrapcdn.com/bootstrap/4.1.2/css/bootstrap.min.css" rel="stylesheet" /> <link href="https://code.jquery.com/ui/1.12.1/themes/base/jquery-ui.css" rel="stylesheet" /> <script src="https://stackpath.bootstrapcdn.com/bootstrap/4.1.2/js/bootstrap.min.js"></script> <script src="https://cdnjs.cloudflare.com/ajax/libs/jquery/3.3.1/jquery.min.js"></script> <script src="https://code.jquery.com/ui/1.12.1/jquery-ui.js"></script> <div class="container commonDivInvoice"> <div class="form-row"> <div class="form-group col-xs-6 col-sm-6 col-md-6 col-lg-2"> <label for="supplierInput">Supplier</label> <select name="supplierInput" id="supplierInput" class="form-control"> <option disabled="disabled" selected="true"> select supplier</option> <option>Supplier 1</option> <option>Supplier 2</option> </select> </div> </div> <div class="row tableInvoice" id="commonDvScroll"> <table class="table table-bordered" id="tableInvoice"> <thead> <tr> <th id="itemNameth" class="commanth">Item Name</th> <th id="itemCodeth" class="commanth">Item Code</th> <th id="unitQtyth" class="commanth">Unit Qty</th> <th id="purRateth" class="commanth">Pur.Rate</th> <th id="discPercentageth" class="commanth">Disc%</th> <th id="discAmtth" class="commanth">Disc Amt</th> <th id="gstPercentageth" class="commanth">Gst%</th> <th id="gstAmtth" class="commanth">Gst Amt</th> <th id="totalAmtth" class="commanth">Total Amount</th> </tr> </thead> <tbody> </tbody> </table> </div> <div class="row"> <table class="table table-bordered" id="tfootTable" style="display: none;"> <tfoot> </tfoot> </table> </div> <button type="button" class="commonButton" id="clear"> <i class="fa fa-eraser"></i> Clear </button> </div> Edit/Update I ahve edited my snippet when I press enter and if it is Disc% input field then I am creating new row, so when I change the dropdown i.e supplier name it is taking previous one data Suppose I select supplier 1 So I am entering(Typing in input fields) and tabledata is in working , but when I select supplier 2 and enter data first row gets the tableData1 but when I enter and create row the nex row shows supplier 1 data A: Your issue is in this line: function getValues(row) { const search = ($('[name=itemNametd]', row).val()).toString() console.log("search : " + search); const value = data[search]; // this one is causing issue ^^^^ The data variable continues to have the first value. I would suggest to simplify the code. But if there is no chance you may simply save the data value as a data attribute to the autocomplete widget and get its value when needed. Take a look to .data() or dataset for details. You can save the data value when you create the autocomplete: $("[name=itemNametd]", tbody).last().autocomplete({ source: autoCompleteData }).data('tableData', data); You can get the value after: function getValues(row) { const search = ($('[name=itemNametd]', row).val()).toString() console.log("search : " + search); var data = $('[name=itemNametd]', row).data('tableData'); // <--- added const value = data[search]; // this one is causing issue var tableData = { "ALMOND CHBAR~2402": { "itemName": "ALMOND CHBAR", "itemCode": "2402", "costPrice": 20.0, "gstPercentage": 14.5, "mrp": 30.0 }, "A BR SB EX~333": { "itemName": "A BR SB EX", "itemCode": "333", "costPrice": 1.0, "gstPercentage": 0.0, "mrp": 1.0 } } var tableData1 = { "White rice~1001": { "itemName": "White rice", "itemCode": "1001", "costPrice": 50.0, "gstPercentage": 5, "mrp": 65.0 }, "Brown rice~333": { "itemName": "Brown rice", "itemCode": "1002", "costPrice": 90, "gstPercentage": 5.0, "mrp": 110 } } $("#supplierInput").on("change", function (e) { $("tbody").empty(); if (this.value == 'Supplier 1') { populateData(tableData) } else { populateData(tableData1) } }); function populateData(data) { var autoCompleteData = Object.keys(data); function rowappend(tbody) { const markup = '<tr>\ <td>\ <input type="text" class="form-control commanChange" id="itemNametd" name="itemNametd">\ </td>\ <td><input type="text" name="itemCodetd" id="itemCodetd" class="form-control commantd" readonly="readonly"></td>\ <td><input type="text" name="mrptd" id="mrptd" class="form-control commantd" readonly="readonly"></td>\ <td><input type="text" name="purRatetd" id="purRatetd" class="form-control commantd"></td>\ <td>\ <input type="tel" id="unitQtytd"class="form-control commanChange" name="unitQtytd">\ </td>\ <td>\ <input type="tel" id="discPercentagetd"class="form-control commanChange" name="discPercentagetd" >\ </td>\ <td><input type="text" name="discAmttd" id="discAmttd" class="form-control commantd" readonly="readonly"></td>\ <td><input type="text" name="gstPercentagetd" id="gstPercentagetd" class="form-control commantd" readonly="readonly"></td>\ <td><input type="text" name="gstAmttd" id="gstAmttd" class="form-control commantd" readonly="readonly"></td>\ <td><input type="text" name="totalAmttd" id="totalAmttd" class="form-control commantd" readonly="readonly"></td>\ <td style="background-color: white;border: 1px white"><i class="fas fa-times fa-2x remove-btn"></i></td>\ </tr>'; $(tbody).append(markup); setTimeout(function () { $("[name=itemNametd]", markup).last().focus() }, 100); $("[name=itemNametd]", tbody).last().autocomplete({ source: autoCompleteData }).data('tableData', data); // <---- added... } rowappend($('tbody', '#tableInvoice')) function getValues(row) { const search = ($('[name=itemNametd]', row).val()).toString() console.log("search : " + search); var data = $('[name=itemNametd]', row).data('tableData'); // <--- added const value = data[search]; // this one is causing issue CostPrice = value.costPrice; if (value) { $(row).find("[name=itemCodetd]").val(value.itemCode); $(row).find("[name=mrptd]").val(value.mrp); $(row).find("[name=purRatetd]").val(CostPrice); $(row).find("[name=gstPercentagetd]").val(value.gstPercentage); } } $(document).on('focusout', function (e) { const row = e.target.parentElement.parentElement if (e.target.matches("[name=itemNametd]")) { getValues(e.target.parentElement.parentElement) $("[name=purRatetd]").focus(); } }); } <script src="https://cdnjs.cloudflare.com/ajax/libs/jquery/3.3.1/jquery.min.js"></script> <link href="https://stackpath.bootstrapcdn.com/bootstrap/4.1.2/css/bootstrap.min.css" rel="stylesheet"/> <link href="https://code.jquery.com/ui/1.12.1/themes/base/jquery-ui.css" rel="stylesheet"/> <script src="https://stackpath.bootstrapcdn.com/bootstrap/4.1.2/js/bootstrap.min.js"></script> <script src="https://cdnjs.cloudflare.com/ajax/libs/jquery/3.3.1/jquery.min.js"></script> <script src="https://code.jquery.com/ui/1.12.1/jquery-ui.js"></script> <div class="container commonDivInvoice"> <div class="form-row"> <div class="form-group col-xs-6 col-sm-6 col-md-6 col-lg-2"> <label for="supplierInput">Supplier</label> <select name="supplierInput" id="supplierInput" class="form-control"> <option disabled="disabled" selected="true"> select supplier</option> <option>Supplier 1</option> <option>Supplier 2</option> </select> </div> </div> <div class="row tableInvoice" id="commonDvScroll"> <table class="table table-bordered" id="tableInvoice"> <thead> <tr> <th id="itemNameth" class="commanth">Item Name</th> <th id="itemCodeth" class="commanth">Item Code</th> <th id="unitQtyth" class="commanth">Unit Qty</th> <th id="purRateth" class="commanth">Pur.Rate</th> <th id="discPercentageth" class="commanth">Disc%</th> <th id="discAmtth" class="commanth">Disc Amt</th> <th id="gstPercentageth" class="commanth">Gst%</th> <th id="gstAmtth" class="commanth">Gst Amt</th> <th id="totalAmtth" class="commanth">Total Amount</th> </tr> </thead> <tbody> </tbody> </table> </div> <div class="row"> <table class="table table-bordered" id="tfootTable" style="display: none;"> <tfoot> </tfoot> </table> </div> <button type="button" class="commonButton" id="clear"> <i class="fa fa-eraser"></i> Clear </button> </div>

Bitcoin adoption Adoption is the acceptance of an innovative product by potential users. The rate of adoption can vary widely among specific demographic groups and the general public. Bitcoin adoption is the extent to which Bitcoin is used and accepted as payment by individuals and institutions. Disclaimer: Any financial and market information given on u.today is written for informational purpose only. Conduct your own research by contacting financial experts before making any investment decisions. This site uses cookies for different purposes. Please set your preferences in Cookie Settings and visit our Cookie policy for more information on how and why cookies are used on this site. Click here for cookie policy

Diabetes mellitus and coronary heart disease. Diabetes mellitus, especially type 2 diabetes, is a growing concern in America. Longitudinal trends show that obesity is more prevalent than in the past, and the incidence of type 2 diabetes is also increasing. Type 2 diabetes typically doubles the CHD risk in men and triples the risk in women. Intervening to control lipid levels and blood pressure has been shown to be especially helpful in preventing CHD, but the impact of better glycemic control on CHD risk is less convincing, especially in clinical trials. Revascularization studies in diabetics show that coronary bypass surgery is related to better outcomes than angioplasty procedures.

The objective of the proposed project is to provide an empirically-based understanding of preschool oral language and preliteracy skill development in children from Spanish-speaking families. The language skills that children from Spanish-speaking homes present at school entry are highly variable and poorly understood. The knowledge base regarding the processes and outcomes of dual language development is inadequate either to design maximally effective educational programs or to match children to the programs they need. There is currently more information available on dual language learners in school than on the factors that shape their readiness for school. The method of the proposed project is a 2 1/2- year longitudinal study of 120 children in the U.S. who have one or two native Spanish-speaking parents and a control group of 60 monolingual English-learning children. At 6-month intervals from the age of 2 1/2 to 5 years, detailed assessments will be made of properties of the children's environments and their language experiences inside and outside the home. In the first year, assessments will be made of the quantity and quality of caregivers' child-directed speech (in both languages for the dual language learners) based on videorecorded caregiver-child interaction. At each assessment point, the children's receptive and expressive speech and language skills (in both languages for the dual language learners) will be assessed using standardized tests, investigator-developed instruments, and spontaneous speech samples. The specific aims of the analyses are (1) to describe and predict trajectories of speech and language development in Spanish-English dual language learners and monolingual English learners from 2 1/2 to 5 years, (2) to identify, among dual language learners, predictors of successful bilingual proficiency at ages 4 and 5 and indicators of risk for low levels of dual language achievement, and (3) to predict preliteracy skills in dual language learners at age 5 years. The large and growing number of children in the U.S. who live in Spanish-speaking homes makes their academic achievement a public health concern. An estimated 35 million households in the U.S. speak Spanish, and many children who hear a language other than English at home reach school age with low levels of English language skills. The cost of educating children with limited English proficiency is as much as 90% greater than the average cost per child. Despite that expenditure, children with limited English skills are statistically at risk for low academic achievement and its many attendant negative consequences. Efforts to improve these outcomes are hampered by the currently poor scientific understanding of the process of early dual language development. The results of the proposed research will provide a scientific foundation for programs and practices to support the school readiness and ultimate academic success of a substantial portion of the nation's children.

1946 Mississippi State Maroons football team The 1946 Mississippi State Maroons football team represented Mississippi State College during the 1946 college football season. They went 8-2 in 10 games played and got the highest rank of #19 on the AP Poll. Schedule References Mississippi State Category:Mississippi State Bulldogs football seasons Category:1946 in Mississippi

// Boost.Units - A C++ library for zero-overhead dimensional analysis and // unit/quantity manipulation and conversion // // Copyright (C) 2003-2008 Matthias Christian Schabel // Copyright (C) 2008 Steven Watanabe // // Distributed under the Boost Software License, Version 1.0. (See // accompanying file LICENSE_1_0.txt or copy at // http://www.boost.org/LICENSE_1_0.txt) #ifndef BOOST_UNITS_VELOCITY_DERIVED_DIMENSION_HPP #define BOOST_UNITS_VELOCITY_DERIVED_DIMENSION_HPP #include <boost/units/derived_dimension.hpp> #include <boost/units/physical_dimensions/length.hpp> #include <boost/units/physical_dimensions/time.hpp> namespace boost { namespace units { /// derived dimension for velocity : L T^-1 typedef derived_dimension<length_base_dimension,1, time_base_dimension,-1>::type velocity_dimension; } // namespace units } // namespace boost #endif // BOOST_UNITS_VELOCITY_DERIVED_DIMENSION_HPP

Solution Statistics Solution Comments There are, here at Cody, a lot of people who can code very well on Matlab. But I find that every one who publish a problem should have the humility to wait for many solvers before he/she put his/her own solution. But that's only my personal opinion. ;-) J.R.!

831 F.2d 297 Unpublished DispositionNOTICE: Sixth Circuit Rule 24(c) states that citation of unpublished dispositions is disfavored except for establishing res judicata, estoppel, or the law of the case and requires service of copies of cited unpublished dispositions of the Sixth Circuit.James Edward TAYLOR, Petitioner-Appellant,v.Donald CAMPBELL, Warden, et al., Respondents-Appellees. No. 87-5678. United States Court of Appeals, Sixth Circuit. Oct. 13, 1987. Before LIVELY, Chief Judge, MILBURN, Circuit Judge, and GEORGE CLIFTON EDWARDS, Jr., Senior Circuit Judge. ORDER 1 The petitioner appeals the judgment denying his petition for a writ of habeas corpus under 28 U.S.C. Sec. 2254. He now applies to this Court for a certificate of probable cause. 2 The petitioner was indicted by the Madison County (Tennessee) Grand Jury for the offenses of attempting to commit a felony of first degree burglary (two counts), first degree burglary, and being a habitual offender. He was tried by a jury in the Circuit Court of Madison County, Judge James D. Todd presiding. The jury convicted the petitioner on all counts and he was sentenced to life imprisonment. On direct appeal, the Tennessee Court of Criminal Appeals affirmed the convictions, the Tennessee Supreme Court denied leave to appeal thereto, and the United States Supreme Court denied a writ of certiorari. 3 The petitioner then filed this habeas action in the District Court for the Western District of Tennessee, raising a total of seven claims: 4 (1) The charges should have been severed for trial; 5 (2) There was insufficient evidence to support the guilty verdicts; 6 (3) The jury should have been instructed on lesser included offenses; 7 (4) The jury should have been instructed that the petitioner faced life imprisonment as a habitual offender if convicted of the burglary charge; 8 (5) Evidence seized from the petitioner at the time of his arrest should have been suppressed; 9 (6) A statement made by the petitioner to police should have been suppressed; and 10 (7) The jury considered facts not introduced into evidence. 11 The action was assigned to District Judge James D. Todd who entered a thorough 13-page opinion finding the above claims without merit. Relief was denied and this appeal followed. 12 This Court is struck immediately by the fact that this habeas action was handled and disposed of by the same judge who, in a previous judicial capacity, presided over the state court proceedings resulting in the conviction now under attack. In Rice v. McKenzie, 581 F.2d 1114 (4th Cir.1978), the Fourth Circuit Court of Appeals held that a district judge who formerly sat as the Chief Judge of the West Virginia Supreme Court was disqualified under 28 U.S.C. Sec. 455(a) from presiding in a federal habeas action arising from a West Virginia conviction, review of which was denied by the West Virginia Supreme Court during the judge's tenure thereon. In so doing, the court concluded that a reasonable person would have a reasonable basis for questioning the judge's impartiality in the habeas action--the basis for disqualification under Sec. 455(a). The reasoning of the court in Rice is even more persuasive in this case. The seven claims raised by the petitioner all pertain to alleged erroneous rulings in the petitioner's state trial rulings in which Judge Todd directly participated. 13 Based upon the record before us, we conclude that Judge Todd's impartiality reasonably would be questioned in this case and that Judge Todd was required to disqualify himself from any participation therein. 14 It therefore is ORDERED that the petitioner's application for a certificate of probable cause is granted. 15 It further is ORDERED that the district court's judgment of May 6, 1987, is vacated and this action is remanded to the district court for reassignment to another judge for review and disposition. Rule 9(b)(6), Rules of the Sixth Circuit.

Slapped cheek disease. How it affects children and pregnant women. Slapped cheek disease, otherwise known as erythema infectiosum (EI) or 'fifth disease', is a common cause of fever and rash in children. The clinical features in children, and the implications for pregnant contacts will be discussed in this article. Erythema infectiosum is usually a mild self limiting illness in children. Patients are unlikely to be infectious after the rash and other symptoms are present, and children do not need to be excluded from school or childcare. Infection in pregnant women under 20 weeks gestation can lead to miscarriage or hydrops, but in 50% of cases the fetus is unaffected. Pregnant women who are IgM positive require appropriate specialist referral and serial ultrasounds.

Self-assembling of the porphyrin-linked acyclic penta- and heptapeptides in aqueous trifluoroethanol. The conjugates of porphyrin with links to the acyclic penta- and heptapeptides were synthesized to mimic natural multiple porphyrin systems. The linear penta- and heptapeptide with hydrophilic/hydrophobic alternative sequences took a random structure in aqueous trifluoroethanol (TFE). However, these polypeptides took a beta-sheet structure in the same solvent when the N-terminal Cys linked to the porphyrin, suggesting that the conjugates self-assembled via the intermolecular hydrophobic interaction between the porphyrins. The circular dichroism (CD) spectra, UV/vis spectra, size exclusion chromatography (SEC), and (1)H NMR spectroscopy supported the self-assembling. In the self-assembled structure of the pentapeptide linking porphyrin at the p-phenyl position (9), the porphyrins were involved in two porphyrin-porphyrin interactions, i.e., the side-by-side interaction between the neighboring polypeptide chains and the face-to-face interaction between the first and the third peptide chains. The CD spectra of 9 showed two sets of Cotton effects probably arising from these two interactions. The UV/vis spectra also supported the above interpretation, showing multiple absorptions in the longwave and shortwave shifted regions. The SEC analyses showed the assembled structure of the conjugates. The (1)H NMR signals of the porphyrin rings of 9 were hardly observed in D(2)O-CD(3)OD because of the shortened spin-spin relaxation time T(2)().

March 30, 2010 Every once in a while DigElog ROCORI will feature a full length performance from one of the various choir groups around the community. Here is your chance to see a full length performance from the Peace Lutheran Church Choir from their March 28, 2010 service. The group sang beautifully that day, so check out this uplifting performance. ****************************** This story was sponsored by Granite Country Computing (GCC) of Cold Spring. John Larson, owner of GCC, is your local authorized CLEARWIRE dealer and installer. Granite Country Computing does all kinds of computer installation, repair and support. November 17, 2008 By recognizing that the Golden Rule is fundamental to all world religions, the Charter for Compassion can inspire people to think differently about religion. This Charter is being created in a collaborative project by people from all over the world. It will be completed in 2009. The Charter for Compassion is a collaborative effort to build a peaceful and harmonious global community. Bringing together the voices of people from all religions, the Charter seeks to remind the world that while all faiths are not the same, they all share the core principle of compassion and the Golden Rule. The Charter will change the tenor of the conversation around religion. It will be a clarion call to the world. Over the next months this site will be open for the world to contribute to Charter for Compassion. Using innovative group decision-making software, people of all faiths, from all across the globe, will contribute their words and stories on a website designed specifically for the Charter. A Council of Sages, made up of religious thinkers and leaders, will craft the world’s words into the final version of the Charter. The document will not only speak to the core ideas of compassion but will also address the actions all segments of society can take to bring these ideas into the world more fully. The Charter for Compassion will then be signed by religious leaders of all faiths at a large launch event, followed by a series of other events to publicize and promote the Charter around the world. Governor of New York, Lieutenant Governor of New York, Mayor of Detroit: Recently, the men occupying these powerful posts have had their sexual indiscretions publicly aired. The Governor’s alleged cross-state tryst with a prostitute, and the mayor’s indictment for perjury in his previous denial of sexual impropriety entangled in government business, could subject both to felony charges. Governor Eliot Spitzer, now-Governor David Paterson, and Mayor Kwame Kilpatrick thus join the ranks of American political (and religious) leaders whose legacies have been marred or even destroyed by sex scandals. Among the reports and commentaries I have sampled on these three events, none thus far has offered a perspective that will provide future governmental leaders with any real help in staying the path. Heightened fear, perhaps. But fear subsides over time — or is decisively over-ruled in the moment by the powerful urges of (what I like to call) our “Lizard Legacy,” supercharged by jolts of testosterone that are both cause and consequence of a significant rise in status. As I wrote in my book (referring to the fall of Pastor Ted Haggard and the impeachment proceedings of President Bill Clinton), “Have we learned anything from these personal and public tragedies? I would venture this: So long as religious and political leaders continue to ignore our evolutionary heritage, and thus do not put in place structures of internal and external support that can withstand the high dosages of testosterone that high status and power necessarily confer, then there will be no hope for a less calamitous future. — TGFE p. 148 How, specifically, would an evolutionary understanding offer effective guidance? First, let us consider the science. Again from my book: “Our reptilian brain [what I call, our Lizard Legacy] truly has its own agenda, a set of three ultimate goals: sustenance, survival, and sex. Evolution found ways to make sexual fulfillment extraordinarily pleasurable in order to ensure procreation. But the penis, in particular, doesn’t remember the ‘in order to’ part of the deal.” — TGFE p. 147 “Sexual drives that would lead to marital infidelity may, of course, be quiescent in some individuals, but there is a well-established link between high levels of testosterone and how insistent and relentless the sexual drives become. Moreover, there is a well-established link in mammals between gains in status and elevated levels of testosterone. Either can cause an upswing in the other. So even if we begin our social climbing with our internal ‘assassin’ adequately restrained, once our status exceeds a threshold, without support and accountability our elevated hormones may be our undoing. As our secret indiscretions become public, our paleomammalian drive to maintain high status kicks in big time, such that we are tempted to violate other moral principles as well—by lying, blaming others, covering up, perhaps even blackmailing possible informants and threatening them with physical harm. — TGFE p. 147 Science leads to self-understanding, which opens the way for truly effective self-help practices: “Appreciating that unwanted inclinations are part of our heritage doesn’t mean we must do their bidding. But it does help us accept that the yearnings themselves need not be judged as shameful — and thus we don’t have to be in denial about their existence. A man choosing to live in a committed, monogamous relationship with a woman, for example, can accept that sexually promiscuous thoughts (heterosexual and/or homosexual) are natural and to be expected from time to time. This is true even for those who are completely happy with their partner. Only from the stance of acceptance can one effectively notice and then seek peer support and accountability to remain in integrity when unwanted urges do arise.” — TGFE p. 145 “As I walk an evolutionary path of personal salvation, humility is a requisite, for I cannot save myself by myself. Original Sin runs deep. My Lizard Legacy is too powerful, and my Furry Li’l Mammal lives in a world of small and often selfish concerns. I need others and, in fact, I need the Whole of Reality. Here we see another face of deep-time grace in and through evolutionary psychology and brain science. How much more workable to accept ourselves, in all our flaws, rather than to resist those inborn aspects as if they shouldn’t be! Instincts simply are, and we can see how they served our ancestors. Now, how do we go about the task of channeling those energies in integrous ways, with equanimity and insight rather than white-knuckle horror?” — TGFE p. 169 Accountability is key. Here are some practices that promote accountability and community nurturance: “Integrity is not a solo sport; it is a community undertaking. For this reason, I dream of the day when baptism in a Christian church comes to mean this: We know that Original Sin cannot be washed away by a daub of water. Rather, the baptismal act is a commitment by the community to lovingly guide the baptized individual through all of life’s stages and through every challenge, using the awareness and tools that God has revealed and will continue to reveal through the time-tested wisdom of our cultural and religious inheritance and the public revelations of science. The religious community would provide structures of education and support that would acquaint us with our evolved Quadrune Brain: our Lizard Legacy, our Furry Li’l Mammal, our Monkey Mind, and our Higher Porpoise. In adolescence and continuing throughout adulthood, our baptismal community would be counted for peer counseling, recovery work, and encouragement of our Higher Porpoise through participation in evo-integrity groups.” — TGFE p. 174 In summary, “There is profound relief in knowing that the inclinations we most dislike in ourselves and others are often not of our or their own doing. In a way, our flaws are not our fault. We didn’t choose them; nor did others. We all, to some extent, inherited them. Our inherited proclivities were shaped by the particulars of our human, mammalian, and vertebrate evolutionary journeys, nuanced by the developmental journey each of us navigates from womb to tomb. This gift of understanding is the foundation for any lasting transformation. It encourages us to move beyond denial or condemnation and simply accept that there are powerful drives within all of us that we did not choose. Once relaxed and accepting, we can begin to forgive self and others for past transgressions. This forgiveness, in turn, clears the board and gives us the courage to look full-square at our current situation and from that vantage to embark on realistic paths for bettering our lives, enriching our relationships, and blessing our world.” — TGFE p. 154 The presentation, given by Rev. Michael Dowd, is based on his recentlypublished book of the same title, which has been ENDORSED BY 5 NOBELPRIZE-WINNING SCIENTISTS and dozens of other luminaries across the religiousand philosophical spectrum: http://ThankGodforEvolution.com/nobel December 26, 2007 It's just a small, white envelope stuck among the branches of our Christmas tree. No name, no identification, no inscription. It has peeked through the branches of our tree for the past 10 years or so. It all began because my husband Mike hated Christmas---oh, not the true meaning of Christmas, but the commercial aspects of it... overspending...the frantic running around at the last minute to get a tie for Uncle Harry and the dusting powder for Grandma---the gifts given in desperation because you couldn't think of anything else. Knowing he felt this way, I decided one year to bypass the usual shirts, sweaters, ties and so forth. I reached for something special just for Mike. The inspiration came in an unusual way. Our son Kevin, who was 12 that year, was wrestling at the junior level at the school he attended; and shortly before Christmas, there was a non-league match against a team sponsored by an inner-city church, mostly black. These youngsters, dressed in sneakers so ragged that shoestrings seemed to be the only thing holding them together, presented a sharp contrast to our boys in their spiffy blue and gold uniforms and sparkling new wrestling shoes. As the match began, I was alarmed to see that the other team was wrestling without headgear, a kind of light helmet designed to protect a wrestler's ears. It was a luxury the ragtag team obviously could not afford. Well, we ended up walloping them. We took every weight class. And as each of their boys got up from the mat, he swaggered around in his tatters with false bravado, a kind of street pride that couldn't acknowledge defeat. Mike, seated beside me, shook his head sadly, "I wish just one of them could have won," he said. "They have a lot of potential, but losing like this could take the heart right out of them." Mike loved kids-all kids-and he knew them, having coached little league football, baseball and lacrosse. That's when the idea for his present came. That afternoon, I went to a local sporting goods store and bought an assortment of wrestling headgear and shoes and sent them anonymously to the inner-city church. On Christmas Eve, I placed the envelope on the tree, the note inside telling Mike what I had done and that this was his gift from me. His smile was the brightest thing about Christmas that year and in succeeding years. For each Christmas, I followed the tradition---one year sending a group of mentally handicapped youngsters to a hockey game, another year a check to a pair of elderly brothers whose home had burned to the ground the week before Christmas, and on and on. The envelope became the highlight of our Christmas. It was always the last thing opened on Christmas morning and our children, ignoring their new toys, would stand with wide-eyed anticipation as their dad lifted the envelope from the tree to reveal its contents. As the children grew, the toys gave way to more practical presents, but the envelope never lost its allure. The story doesn't end there. You see, we lost Mike last year. When Christmas rolled around, I was still so wrapped in grief that I barely got the tree up. But Christmas Eve found me placing an envelope on the tree, and in the morning, it was joined by three more. Each of our children, unbeknownst to the others, had placed an envelope on the tree for their dad. The tradition has grown and someday will expand even further with our grandchildren standing around the tree with wide-eyed anticipation watching as their fathers take down the envelope. Mike's spirit, like the Christmas spirit, will always be with us. May we all remember Christ, and "give" in a Christ-like manner. After all, he is the reason for the season, and the true "Christmas spirit" this year and always. December 23, 2007 Logan is a 13 year-old boy who lives on a ranch in a very small town in Nebraska. Logan listens to Christian Radio station 89.3FM KSBJ which broadcasts from Houston, TX. Logan called the radio station distraught because he had to take down a calf . His words have wisdom beyond his years. August 18, 2007 This summer, after 26 years, Brother Paul Richards, dreamer, founder, director, visionary, promoter and leader of the St. John's Boys' Choir of Central Minnesota has stepped down from his position with the group. He leaves behind a positive legacy that this story only skirts the very edge of the iceberg seen above the water... let alone the 90% of the iceberg left unseen below the water. The text below was taken from the Boys' Choir Website, submitted by Brother Paul last year. The saying that suggests ‘history has a way of repeating itself,’ rings true for The St. John’s Boys’ Choir. In 1981, the Choir was founded to provide opportunities for boys while bringing extraordinary music to area residents. We stayed true to our mission, building a viable organization with sustaining impact on Choir members, families, teachers and others associated with The St. John’s Boys’ Choir. To say that I am proud of the Choir’s achievements would be a serious understatement. Our music program is solid; we have earned a strong national and international reputation. Though always a challenge, our financial position promotes long-term viability. Friends have been generous and we have successfully entered the realm of grants and fundraising (keep those critical dollars coming). In addition to our strengths in music and finances, I must commend the boys and their families for their hard work and, sometimes, difficult decisions made in order to meet the demands and responsibilities associated with being part of the Choir. The administrative and professional staff, student workers, Board of Directors, members of the Abbey community….all playing critical roles in the ongoing story of The St. John’s Boys’ Choir. The 26th Season brings another milestone to the Choir’s rich and varied history. The Choir commissioned world-renowned Minnesota composer Stephen Paulus to prepare an opera which would feature boys as the major characters. Working with celebrated librettist Gene Sheer of New York, The Star Gatherer, was developed and celebrated with its world debut by The St. John’s Boys’ Choir at Saint John’s University. This performance is indicative of the Choir’s growth and continued desire to bring great gifts of music and culture to the good people of central Minnesota. You are all stars. Blessings, Br. Paul Richards, O.S.B. Music Director October 13, 2006 Its one of the best stories of the year. Habitat for Humanity does so much for the communities that get involved. In this story Peace Lutheran in Cold Spring helps out in the cause of Habitat for Humanity. Peace joins a multitude of local businesses, volunteers, and contributors to make a house for Ahmed's family. This story will touch the hearts of many as Ahmed will get his family a house. He is a father of three and they have been in the U.S. for about 5 years. His interview really shows just how much this means to him and everyone impacted by Habitat for Humanity. July 20, 2006 A very important asset in the "Land of ROCORI" can be found at Assumption Campus in Cold Spring. At Assumption you'll find a combination of independent living apartments as well as assistant living services that provide fro the needs of the senior who is experiencing some of the final chapters of life. The measure of quaility in any senior home lies not only in the facility rooms and services available, but in the culture and philosophy of the people who provide daily care for the residents. In this story you'll meet both staff and residents at Assumption Campus. After viewing this short informative clip, you'll understand why Assumption has waiting lists for people who are looking forward to becoming a part of this warm and friendly place in our community.