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Evaluation datasets 33

The extraction of upper first molars may be indicated:

Key concept: Any teeth which is having poor prognosis is indicated for extraction.

When the removal of 4/4 provides insufficient space

Where they are rotated

When their prognosis is poor

When 5/5 are palatally placed

Dental

cc08a1e9-291e-4ee6-9b37-90bddf5bc2f5

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Rhinosporidiosis is caused by which of the following?

Rhinosporidiosis is caused by Rhinosporidium seeberi. This organism was previously considered to be a fungus. It is now identified to be an aquatic protistan protozoa parasite belonging to the class Mesomycetzoea. ( Ref Scott Brown, 8th edition, VOL 1, Pg no. 208 )

Fungus

Virus

Bacteria

Protozoa

ENT

Nose and paranasal sinuses

cbbe9911-98fc-4e3e-a941-96e314994b8e

single

Calcinosis universalis occurs in –

Calcinosis universalis is the diffue deposition of calcium salts in the skin, subcutaneous tissue and sometimes in connective tissue. It occurs in Juvenile Dermatomyositis.

Ehlers Danlos syndrome

Christian Weber syndrome

Deimatomyositis

Scleroderma

Dental

03c26382-4b74-43d5-923a-4345e647db76

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Fetal stage starts at:

Fetal Growth Periods

9 weeks

3 weeks

6 weeks

12 weeks

Gynaecology & Obstetrics

8bc8fa51-fdad-4b08-b6b6-15d7a4c3b5b7

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Which of the following belongs to antifibrinolytic drugs

Antifibrinolytic drugs promote blood clotting by preventing blood clots from breaking down. Some examples of antifibrinolytic drugs are aprotinin, tranexamic acid (TXA), epsilon-aminocaproic acid and aminomethylbenzoic acid. Doctors sometimes give these drugs to patients having surgery to prevent blood loss. Ref: KD Tripathi 8th ed.

Alteplase

Urokinase

Aprotinin

Reteplase

Pharmacology

Central Nervous system

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Organism which causes pancreatitis

Mumps

Measles

Candida

Treponema

Medicine

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Longest acting L.A. – a) Bupivacaineb) Tetracainec) Xylocained) Procaine

Dibucaine is the longest acting LA (duration is 2.5-3.5 hours). Amongst the given options tetracaine & bupivacaine are longest acting (both have duration of 2-3 hours). Decreasing order of duration :- Dibucaine (longest acting) > Bupivacaine = Tetracaine = Ropivacaine = Etidocaine > Prilocaine = Lignocaine = Mepivacaine = Cocaine > Procaine > chlorprocaine.

ac

a

ad

ab

Anaesthesia

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single

Which of the following drugs should be given in sustained release oral dosage form?

Sustained release preparation are used for prolonged duration of action of drug . So, used when drug has sho half life and when we require the action of drug for longer duration. Anti-hypeensive drug are used for lifelong. So, sustained release preparations are required. Anti-arrhythmic drugs used in treatment of PSVT are not to be used as sustained release preparation as we need action for only a sho duration. Anti-inflammatory drug with the half life of 24 hrs is already acting for long duration we don't need sustained release preparation. Hypnotic drug with a half life of 2hrs will work for 5-6 hrs. So, no need of sustained release preparation.

An anti-arrhythmic drug with a plasma half life of 10 seconds used for acute treatment of PSVT

An anti-inflammatory drug with a plasma half life of 24 hr

A hypnotic drug with a plasma half life of 2 hours

An antihypeensive with a plasma half life of 3 hours

Pharmacology

Hypeension, Arrhythmias, Dyslipidemia

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Avascular necrosis may be seen in all of the following, except

Common Site of Avascular necrosisCauseHead and femurFracture neck femur (Subcapital)Posterior dislocation of hipProximal pole of scaphoidFracture through waist of scaphoidBody of talusFracture neck of talusProximal pole of lunateLunate dislocation*Other sites of common AVN are Distal medial condyle, Humeral head, Capitellum, and Metatarsal heads*In the early stages, bone scintigraphy and MRI are the diagnostic modalities of choice.*Non ohopedic causes of AVN - Sclera, Caisson's disease, Lupus erythematosus, Radiation and Alcohol (Refer: Apley's system of Ohopedics and Fracture, 8th edition, pg no: 91-103, 436-439)

Scapula

Head of femur

Upper end of humerus

Body of Talus

Anatomy

All India exam

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A child presents with infective skin lesion of the leg culture was done which showed gram+ve cocci in chains which where hemolytic colonies. The test to confirm the organism is -

Bile solubility

Optochin sensitivity

Bacitracin sensitivity

Catalase positive

Microbiology

f4686c11-7ff6-4f34-abf2-625e405848fe

single

Which antiepileptic drug is least secreted in breast milk -

Ans. is 'b' i.e., Clonazepam DrugBreast milk to plasma concentrationCarbamazepine0-69Clonazepam033Ethosuximide0-94Gabapentin0-7-1-3Lamotrigine0-057-1-47Phenobarbitone0-4-0-6Phenytoin018-0-45Primidone0-72Topiramate0-86-1-1Valproate0-42Zonisamide0-93

Ethosuximide

Clonazepam

Gabapentin

Carbamazepine

Pharmacology

Epilepsy

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Therapeutic drug monitoring is done for all of the following drugs Except

TDM is not done for most commonly used drugs or safe drugs like paracetamol, diclofenac done for antiepileptic drugs, immunosuppressants, anticancer drugs, lithium Phenytoin- antiepileptic, cyclosporin, tacrolimus- immunosuppressants in the options not done for antihypeensives and BP can be measured clinically and easily REF KD Tripathi 8th ed

Phenytoin

diclofenac

Tacrolimus

Cyclosporine

Pharmacology

General pharmacology

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β-blocker with additional α-blocking property is

Propranolol

Timolol

Metoprolol

Labetalol

Pharmacology

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The following methods can be used to detect the point mutation in the beta globin gene that causes sickle cell anemia, EXCEPT:

Point mutation involves the replacement of a single base nucleotide with another nucleotide of the gene. Point mutations in the beta globin gene can be identified by analysing the DNA. Nohern blot is a technique used in studying the RNA and hence the answer of exclusion. Ref: Introduction to Biotechnology By Thieman William, 2nd Edition, Pages 71, 78, 81, 82

Polymerase chain reaction with allele-specific oligonucleotide hybridization

Southern blot analysis

DNA sequencing

Nohern blot analysis

Biochemistry

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Cranial irradiation is also indicated in the treatment of which variety of lung cancer?

Small cell lung cancers or oat cell carcinomas, exhibits aggressive behavior, with rapid growth, early spread to distant sites, exquisite sensitivity to chemotherapy and radiation, and frequent association with distinct paraneoplastic syndromes. Surgery usually plays no role in its management. Widespread metastases occur early in the course of the disease, with common spread to the mediastinal lymph nodes, liver, bones, adrenal glands, and brain. Management of limited-stage small cell lung cancer involves combination chemotherapy, usually with a platinum-containing regimen, and thoracic radiation therapy. If the patient achieves a complete remission, he or she would be offered prophylactic cranial irradiation.

Squamous cell carcinoma

Non small cell cancer

Small cell cancer

Adenocarcinoma

Radiology

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The disease most likely to result In presents of emotional contact is

The poal of entry of measles virus is through the respiratory tract or conjunctivae following contact with large droplets or small-droplet aerosols in which the virus is suspended. Reference: Nelson textbook of pediatrics 19th edition.Page 1070

Measles

Typhoid

SSPE

All of above

Pediatrics

Infectious disease

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All of the following are signs of chronic liver failure, Except:

Answer is D (Subcutaneous nodules): Subcutaneous nodules are generally not seen as stigmata of chronic liver disease. Chronic Liver Disease manifests with loss of subcutaneous fatty tissue resulting in paper thin skin with marked folds (paper-money skin).

Palmer erythema

Spider nevi

Testicular atrophy

Subcutaneous nodules

Medicine

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Immediate management of a child with foreign body inhalation is -

Ans. is 'b' i.e., Bronchoscopy Treatment of aspirated foreign body A) Treatment of foreign body in upper respiratory tract. o If obstruction is complete --> Immediate intervention. o If obstruction is paial --> Patients should allow to use their own cough reflex to extrude the foreign body --> If it fails than intervention should be done. o Method of removal of foreign body : - 1)If child is younger than 1 year --> Child should be placed face down over the rescuir's arm with head positioned below trunk. Five measured back blows are delivered rapidly between the scapula. If obstruction persists, the infant should be rolled over and five rapid chest compressions should be performed. This sequence is repeated until the obstruction is relieved. 2) If child is elder than 1 year ---> Abdominal thursts (Heimlich maneuver) should be performed. B) Treatment of foreign body in lower respiratory tract. o The treatment of choice is prompt endoscopic (bronchoscopic) removal of foreign body.

IPPV

Bronchoscopy

Tracheostomy

Exploratory Thoracotomy

Pediatrics

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Slipped capital femoral epiphysis is seen most commonly in which age group -

Slipped capital femoral epiphysis (SCFE) occurs during adolescent rapid growth period when epiphysis plate is weak & the capital epiphysis is displaced down & back. * Etiology : age - 10-17years of age Sex- male : female - 5:2 Location: left hip is involved in 58% of the cases *stages 1. Preslipping stage 2.chronic slipping stage 3.stage of fixed deformity *Radiographic changes - *early change : marginal blurring of the proximal metaphysis , lower margin of metaphysis is included within the acetabulum normally but excluded in the early epiphyseal slip, Trethovan &;s line : line drawn along the superior margin of the neck , transects the epiphysis normally , but will be above it in slip, depth of epiphysis is reduced , there is a step between metaphysis & epiphysis. *Late changes : trethovan&;s sign is present , head is atrophic , neck shaft angle is less than 90 degree , new bone formation is seen at the anterior superior pa of neck , joint space is clear , shenton&;s line is broken. * CT scan is very useful in assessing degree of slips. Classification of slipping - mild(51%), moderate(22%), severe slipping (17%) REF:Essential ohopedics, John Ebenezer, 4th edition, pg.no.416

Infants

Adolescents

Old age

Childhood

Orthopaedics

Pediatric orthopedics

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All are true about vitamin E except ?

Ans. is 'c' i.e., Water soluble vitamin Vitamin E is a fat soluble vitamin (not water soluble). All other options are correct.

Act as antioxidant

Prevent lipid peroxidation of cell membrane

Water soluble vitamin

Chemically tocopheral

Biochemistry

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Contents of the suboccipital triangle are formed by all of the following structures, EXCEPT:

The contents of the suboccipital triangle are veebral aery, suboccipital nerve and greater occipital nerve.The suboccipital triangle is the area in the suboccipital region between the rectus capitis posterior major and the obliquus capitis superior and inferior muscles. It is covered by a layer of dense fibro-fatty tissue, deep to the semispinalis capitis muscle. Its floor is formed by the posterior occipitoatlantal membrane and the posterior arch of the C1 veebrae. The suboccipital muscles are:Obliquus capitis superior muscleObliquus capitis inferior muscleRectus capitis posterior major muscleRectus capitis posterior minor muscleRef: Moon D.A., Foreman K.B., Albeine K.H. (2011). Chapter 1. Back.

Veebral aery

Suboccipital nerve

Greater occipital nerve

Lesser occipital nerve

Anatomy

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Common Facial vein is formed by the union of

The scalp on each side of the midline is drained by five veins. The veins of the scalp accompany the arteries and have similar names. These are as follows: Supratrochlear and supraorbital veins: They join each other at the medial angle of the eye to form the angular vein, which continues downwards as the facial vein behind the facial artery. Superficial temporal vein: It descends in front of tragus to enter the parotid gland where it joins the maxillary vein to form the retromandibular vein, which terminates by dividing into anterior and posterior divisions. The anterior division unites with the facial vein to form common facial vein, which drains into the internal jugular vein. Posterior auricular vein: It descends behind the auricle and  unites with the posterior division of the retromandibular vein to form the external jugular vein, which drains into the subclavian vein. Occipital vein: It terminates in the suboccipital venous plexus.

Anterior facial and posterior facial veins

Anterior facial and posterior auricular veins

Anterior facial and maxillary veins

Anterior facial and anterior branch of the posterior facial vein

Anatomy

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Branches of brachial aery are all EXCEPT:-

Radial collateral aery is anterior descending branch of the profunda brachii aery, not a direct branch of brachial aery.

Profunda brachii

Superior ulnar collateral

Inferior ulnar collateral

Radial collateral

Anatomy

Upper limb : Miscellaneous

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During which phase of the cell cycle the cellular content of DNA is doubled -

There are two resting phases and two active phases in the cycle. Resting phases → G1 & G2 Active phases S-phase (synthetic phase) - As the name suggests, synthesis of new DNA takes place, i.e. doubling of DNA occurs. M-phase (mitotic phase) - Mitosis takes place and the daughter cells receive one copy of DNA. In this phase, cell number is doubled.

Mitotic phase

G1 phase

G2 phase

S phase

Pathology

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Pancreatic pseudocyst most commonly occurs after ?

Ans. is 'b' i.e. Pancreatitis Most common cause of pancreatic pseudocyst is Pancreatitis (90%) The second most common cause is trauma (10%). Pseudocysts are seen in both acute and chronic pancreatitis.

Trauma

Pancreatitis

Pancreatic surgery

Pancreatic malignancy

Surgery

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Major epidemics are due to antigenic drift

Asymptomatic seen rarely

Incubation period 10-12 hrs

All ages and sex equally affected

Pandemic rare

Social & Preventive Medicine

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Disability adjusted life year (DALY) is a measure of ?

Ans. is 'b' i.e., Effectiveness of treatment Disability - adjusted life year (DALY) DALY is a measure of :- The burden of disease in a defined population The effectiveness of interventions It expresses years lost to premature death and years lived with disability adjusted for the severity of the disability. That means, DALY measures both moality and disability together (in contrast to sullivan's index which is related to disability only). One DALY is one lost year of healthy life. DALY combines following : - Years of lost life (YLL). Years lost to disability (YLD) DALY = YLL + YLD Japanese life expectancy statistics are used as a standard for measuring premature death, as Japanese have the longest life expectancy. Health - adjusted life expectancy (HALE) HALE is the indicator used to measure healthy life expectancy. HALE is based on the life expectancy at bih but includes an adjustment for time spent in poor health. It is the equivalent number of years in full health that a newborn can expect to live based on current rates of ill health and moality.

Life expectancy

Effectiveness of treatment

Quality of life

Human development

Social & Preventive Medicine

8c3a9523-e068-4739-8112-442278ce8e2e

single

A drug X is secreted through renal tubules, tubular secretion of this drug can be confirmed if renal clearance of drug X is:

* After filtration from glomerulus, a drug may undergo two processes (tubular reabsorption and tubular secretion) before going out from the body i.e. renal clearance *Suppose 100 mg of a drug is filtered by glomerulus and the renal clearance is 150 mg, it means 50 mg is coming from somewhere else, i.e. tubular secretion must be present. However, we cannot say that reabsorption is not occuring because if 20 mg is reabsorbed and 70 mg is secreted, same thing can happen. * Suppose, 100 mg of a drug is filtered but renal clearance is 50 mg. Therefore, 50 mg must have gone somewhere i.e. tubular reabsorption must be occurring. Again, we cannot say that tubular secretion is not present.

More than the GFR

Equal to the GFR

Less than the GFR

More than volume of distribution

Pharmacology

Pharmacokinetics

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A 28-year-old woman presented with high-grade fever, cough, diarrhea and mental confusion for 4 days. X-ray chest revealed bilateral pneumonitis. Search for etiology will most likely reveal?

The clinical profile of fever, cough and X-ray revealing bilateral pneumonitis and presence of diarrhea and confusion indicates the presence of Atypical pneumonia. The organism causing atypical pneumonia out of the given choices is Legionella pneumophila Confusion can be explained by hyponatremia due to SIADH. The clinical manifestations of Legionnaires' disease are usually more severe than those of most "atypical" pneumonias. Clinical Clues Suggestive of Legionnaires' Disease Diarrhea High fever (>40degC; >104degF) Numerous neutrophils but no organisms revealed by Gram's staining of respiratory secretions Hyponatremia (serum sodium level <131 mg/dL) Failure to respond to b-lactam drugs (penicillins or cephalosporins) and aminoglycoside antibiotics Occurrence of illness in an area where potable water supply is known to be contaminated with Legionella Onset of symptoms within 10 days after discharge from the hospital (hospital-acquired legionellosis manifesting after discharge or transfer)

Streptococcus pneumonia

Staphylococcus aureus

Legionella pneumophila

Pseudomonas aeruginosa

Medicine

Pneumonia

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Not true about microtubules is/are:

D i.e. GTP not required

Dynamic instability

Polarity

Charged

GTP not required

Physiology

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multi

Which of the following statements is FALSE regarding vincristine

Vincristine is a vinca alkaloid. It is used for the induction of remission in ALL. It is a marrow sparing drug but causes peripheral neuropathy, alopecia and SIADH as adverse effects.

It is an alkaloid

Its use is associated with neurotoxicity

It does not cause alopecia

It is a useful drug for induction of remission in acute lymphoblastic leukemia

Pharmacology

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Which of the following not a prion associated disease -

scrapie,CJD&Kuru are prion disease REF:ANATHANARAYANAN MICROBIOLOGY NINTH EDITION PAGE.557

Srapie

Kuru

Creutzfeldt Jakob disease

Alzheimer's disease

Microbiology

Virology

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Systemic inflammatory response syndrome, false is

Answer- A. HypoglycemiaIt is an inflammatory state affecting the whole bodn frequently a response of the immune system to infection, but not necessarily so.When two or more of these criteria are met with or without evidence of infection -Body temperature less than 36 c greater than 38 CHea rate greater than 90 beats per minuteTachypneaWhite blood cell count less than 4000 cells/mm3HyperglycemiaAltered mental state

Hypoglycemia

Fever

Leukocytosis

Altered mental status

Pathology

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Neuraminidase inhibitor ?

Ans. is 'a' i.e., Oseltamivir Oseltamivir acts by inhibiting influenza virus neuraminidase enzyme which is needed for release of progeny virions from the infected cell.

Oseltamivir

Amantadine

Enfuviide

Formivirsen

Pharmacology

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The recent treatment of sho bridle passable stricture of urethra in the penile and bulbous urethra is

Endoscopic (internal) urethrotomy Internal urethrotomy is performed using the optical urethrotome. The stricture is cut under visual control using a knife passed through the sheath of a rigid urethroscope. The stricture is usually cut at the 12 o'clock position, taking care not to cut too deeply into the vascular spaces of the corpus spongiosum that surrounds the urethra. It is possible to get lost when trying to cut a way through a very tight stricture, and this is especially true when there are false passages because of previous dilatation attempts. Accordingly, a guidewire should be passed through to the bladder prior to incision of the stricture in order to establish the true lumen of the urethra. Following urethrotomy a catheter should be left in situ for 1-3 days afterwards. A single urethrotomy seems to give a permanent cure of an uncomplicated stricture in about 50% of patients. Success rates are highest when the stricture is sho and when it is present within the bulbar urethra. In contrast, failure rates are highest in long strictures, strictures within the penile urethra and in recurrent strictures. The main complications are infection and bleeding. Ref: Bailey and love 27th edition Pgno : 1484

Internal urethrotomy with Thompson-Walker's urethrotome

Optical internal urethrotomy

Syme's operation

Wheelhouse operation

Surgery

Urology

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CD8 antigen is present on

CD4 antigen is present on t helper cells Cd8 antigen on T suppressor cells CD8 cells recognize MHC class I antigens Ref: Textbook of Microbiology Baveja 5th ed Pg 135

T helper cells

B cells

T suppressor cells

Macrophages

Microbiology

Immunology

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Hemolytic disease of newborn is least common with which blood group female -

Ans. is 'c' i.e., OABO incompatibility has a protective effect to the development of Rh sensitization and thus the development of hemolytic disease of newborn

A

B

0

AB

Gynaecology & Obstetrics

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Primary spermatocytes, chromoso me is -

Ans. is 'c' i.e., 46-XY Secondary spermatocyte (Haploid -23)-Spermatid(Haploid-23)Spermatogonia - Primary spermatocyteDiploid-46)(Diploid-46)Secondary spermatocyte (Haploid-23)-Spermatid(Haploid-23)

23-X

23-Y

46-XY

None

Physiology

Sex Hormones

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Chlamydia Trachomatis, false is

Ans. is 'a' i.e. Elementary body is metabolically active Chlamydiae is a gram negative bacteria that are obligate intracellular parasitesThey require the host's ATP as an energy source for their own metabolism. They have a cell membrane transport system that takes on ATP from the host cell and then return backs an ADP. This is called ATP/ADP translocator. Chlamydia life cycleThe chlamydia life cycle is complex as the bacteria exists in two forms (biphasic)Elementary bodyIt is a metabolically inert (does not divide), dense, round, small (300 nm) infectious particle.The outer membrane has extensive disulfide bond cross-linkages that confer stability for extracellular existence.It is an infectious particle that spreads from host to host.Initial body (also called reticulate body)Once inside a host cell the elementary body inhibits phagosome lysosome fusion and grows in size to 1000 nm.Its RNA content increases and binary fission occurs forming the initial body, (initial body)Although the initial body synthesizes its own DNA, RNA and proteins, it requires ATP from the host.Also know * Chlamydia trachomatis has affinity for columnar cells.

Elementary body is metabolically active

It is biphasic

Reticulate body divides by binary fission

Inside the cell it evades phagolysosome

Microbiology

Bacteria

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All of the following statements are true, except

Optic C is true for libman - sacks endocarditis seen in SLE. Refer the byte "Vegetations in Endocarditis".

Infective endocarditis can develop large friable vegetations

Non Bacterial thrombotic endocarditis develops in DIC

Vegetations of Infective endocarditis occurs on both surfaces of cusps

All of the above

Pathology

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Migraine prophylaxis includes:

Trick: Very Volatile Pharma Agent For Migraine Prophylaxis V  →  Verapamil V  →  Valproate P  →  Pizotifen A  →  Amitryptiline F  →  Flunarizine M  →  Methylsergide P  →  Propranolol

Verapamil

Valproate

Amitryptiline

All of the above

Medicine

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A patient with Lefort-II, Lefort-III and nasoethmoidal fracture with intermaxillary fixation done is best intubated by:

Nasal

Oral

Submental

All of the above

Surgery

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Ritgen maneuver is done in

Ritgen manuever is done for delivery of head in normal labor to allow controlled delivery of head. When the head distends the vulva and perineum enough to open the vaginal introitus to a diameter of 5cn of more , a towel is drapled ,gloved hand may be used to exe forward pressure on the chin of fetus through the perineum just in front of coccyx. Concurrently the other hand exes pressure superiorly against occiput. This ours nect extension so that the head is delivered with its smallest diameter passing through the introitus and over perineum

Shoulder dystocia

For delivery of head in breech presentation

For delivery of legs in breech

For delivery of head in normal labour

Anatomy

General obstetrics

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Putting profit ahead of health as a cause of disease is provided by theory of sociology

Marxist theory

Feminist theory

Parsonian theory

Foucauldian theory

Social & Preventive Medicine

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One year old male child presented with poor urinary stream since bih. The investigation of choice for evaluation is -

Ans. is 'a' i.e., Voiding cystourethrography o Poor urinary stream since bih suggests urinary tract obstruction (usually infravesical). o Most common cause of urinary tract obstruction in a male child is posterior urethral valve. o And the best diagnostic method for posterior urethral valve is voiding cystourethrogram.

Voiding cystourethrography (VCUG)

USG bladder

Intravenous urography

Uroflowmetry

Pediatrics

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A 6 year old mentally retarded male child patient presents with hepatosplenomegaly, coarse facial features, corneal clouding, large tongue, prominent forehead, joint stiffness, short stature and skeletal dysplasia. What is the enzyme deficient in this patient?

Mucopolysaccharidosis-I H (Hurler’s Disease): Biochemical defect: Homozygous or double heterozygous nonsense mutation of IDUA gene on Chromosome 4p encoding α-L-Iduronidase. Clinical features of MPS I H (Hurler’s Disease): Progressive disorder with multiple organ and tissue involvement that results in premature death, usually by 10 years of age. An infant with Hurler’s syndrome appears normal at birth, but inguinal hernias are often present. Diagnosis is usually made between 6 and 24 month of age. Hepatosplenomegaly, coarse facial features, corneal clouding, large tongue, prominent forehead, joint stiffness, short stature and skeletal dysplasia are seen. Acute cardiomyopathy has been found in some infants < 1 year of age. Most patients have recurrent upper respiratory tract and ear infections, noisy breathing and persistent copious nasal discharge. Valvular heart disease with incompetence, notably of the mitral and aortic valves, regularly develops, as dose coronary artery narrowing. Obstructive airway disease, notably during sleep, may necessitate trachotomy. Obstructive airway disease, respiratory infection and cardiac complications are the common causes of death.  Key Concept: Hurler's disease is due to α-L- Iduronidase enzyme deficiency due to homozygous or double heterozygous nonsense mutation of IDUA gene on Chromosome 4p encoding α-L-Iduronidase. Reference- Harper’s illustrated biochemistry. 30th edition page no: 179

Iduronate sulfatase

β-Galactosidase

α-L- Iduronidase

β-Glucuronidase

Biochemistry

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multi

Muscle which is not there in a modiolus:

Modiolus is a point where eight muscles meet at the ANGLE OF MOUTH 1. Depressor anguli oris (or) triangularis 2. Levator anguli oris or caninus 3. Risorius 4. Orbicularis oris 5. Buccinator 6. Zygomaticus major 7. Quadratus labii superioris 8. Quadratus labii inferioris

Depressor anguli oris.

Buccinator.

Zygomaticus major.

Zygomaticus minor.

Dental

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single

SAFE strategy for Trachoma includes all of the following except:

A i.e. Screening

Screening

Antibiotic

Face wash

Environmental improvement

Ophthalmology

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multi

Dissection of which aery is seen in pregnancy -

Answer is 'b' i.e. Aoa

Carotid aery

Aoa

Coronary A

Femoral aery

Surgery

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single

All of the follow ing are diaphyseal tumors except-

Ans. is 'd' i.e., Aneurysmal bone cyst Sites of tumorsEpiphyseal tumorsMetaphyseal legionsDianhvseai lesionso Chondroblastomao Giant cell tumor (osteoclastoma)o Clear cell chondrosarcomao Osteogenic sarcomao Unicameral (simple) bone cysto Aneuiysmal bone cysto Fibrous cortical defecto Chondrosarcomao Osteochondromao Enchondromao Osteoblastomao Ewring sarcomao Lymphomaso Fibrous dysplasiao Adamantinomao Histiocytosiso Osteoid osteomao Chondromyxoid fibromao Fibrosarcomao Fibrous cortical defecto Non ossifying fibroma

Ewings sarcoma

Histiocytosis

Fibrosarcoma

Aneurysmal bone cyst

Orthopaedics

Classification of Bone Tumors

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multi

Which of the following acts as an antagonist to NMDA receptor?

Ketamine is a general anesthetic agent which acts by blocking excitatory NMDA type of glutamate receptors.

Ketamine

Spermine

Muscimol

Baclofen

Pharmacology

Central Nervous system

d6e838e0-5cc0-423c-9361-9a8cca679b28

single

Which does not contribute to Enterobillary Fistula ?

Ans. is 'c' i.e. Gastric ulcer

Duodenal ulcer

Gall stones

Gastric ulcer

Carcinoma gall bladder

Surgery

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multi

Atomoxetine is used for ?

Ans. is 'b' i.e., ADHD Atomoxetine it is selective norepinephrine reuptake inhibitor and is approved for use in ADHD. It is indicated in children > 6 years and in adults with concentration and attention problems. Atomoxetine absorbed orally, hydroxylated by CYP2D6 and excreted in urine, mainly as glucuronide. While majority of individuals are extensive metabolizers (EM), few are poor metabolizers (PM) due to polymorphism of CYP2D6. Inhibitors of CYP2D6 like fluoxetine, paroxetine, quinidine increase concentration and toxicity of atomoxetine. It should not be given with MAO inhibitors and is contraindicated in glaucoma.

Nocturnal enuresis

ADHD

Temper tantrums

Patent ductusaeriosus

Pharmacology

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single

Which drug can be administered through all routes?

Ref: Katzung 11th ed. p. 542Explanation:Most opioid analgesics are well absorbed when given by subcutaneous, intramuscular, and oral routes.Rectal suppositories of morphine and hydromorphone have been used when oral and parenteral routes are undesirable.The transderma I patch provides stable blood levels of drug and better pain control while avoiding the need for repeated parenteral injections.Fentanyl has been the most successful opioid in transdermal application and is indicated for the management of persistent unremitting pain.The intranasal route avoids repeated parenteral drug injections and the first-pass metabolism of orally administered drugs.Butorphanol is the only opioid currently available in the USA in a nasal formulation. Butorphanol has shown greater analgesia in women.Another alternative to parenteral administration is the buccal transmucosal route, which uses a fentanyl citrate lozenge or a "lollipop'' mounted on a stick.

Fentanyl

Paracetamol

Penicillin G

Azithromycin

Pharmacology

Pharmacokinetics

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multi

Charcot's/neuropathic joint are most commonly seen in

.

Diabetes Mellitus

Spyringomyelia

Leprosy

Rheumatic Ahritis

Surgery

Trauma

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single

A 24 year old man falls on the ground when he is struck in the right temple by a baseball. While being driven to the hospital, he lapses into coma. He is unresponsive with the dilated right pupil when he reaches the emergency department. The most important step in initial management is -

Craniotomy

CT scan of the head

X-ray of the skull and cervical spine

Doppler ultrasound examination of the neck

Medicine

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multi

Most variable absorption is seen with which route?

Ans. is 'a' i.e., Oral Oral administration of drugs is safe, convenient and economical, but has the potential for the most variable absorption pattern. Clinical pharmacology Routes of drug administration Drugs are administered by various routes. Different routes have different characteristics, so that the route of administration may have a profound effect upon the speed and efficiency with which the drugs act. The routes of drug administration may be: i) Local route ii) Systemic route Local route - Drug is administered at the site of lesion. Systemic route - Drug is administered through systemic routes is intended to be absorbed into the blood stream and distributed all over, including the site of action, through circulation.

Oral

Intramscular

Intravenous

Per rectal

Pharmacology

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single

Pain during injection occurs with all Except

Ketamine is the only intravenous inducing agent that does not cause pain on injectionAgentPain on iv injectionThiopentoneMethohexitonePropofolEtomidateKetamine+/0++++++0

Propofol

Thiopentone

Ketamine

Etomidate

Anaesthesia

All India exam

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multi

Which variety of AML is associated with good prognosis -

Ans. is 'b' i.e., M3 Prognostic factors in AMLGood PrognosisBad Prognosiso Age < 40 yearso Age < 2 years or > 55 yearso M2, M3, M4 forms of AMLo M0, M6, M7 FORMS OF AMLo Blast cell with Auer rodso Complex karyotypeso TLC <25x109/Lo TLC> 100 x 109/Lo t (15;17), t (8;21), inv 16o Deletions 5q, 7q (Monosomy 5 or 7)o Leukemia without preceeding MDSo AML with preceding MDS or anticancer drug exposure

MO

M3

M6

M7

Pathology

Lukemia

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single

Muscle not having dual nerve supply

Anterior belly of digastric is supplied by the trigeminal nerve and posterior belly by facial nerve Spinal accesory nerve and c3,c4 nerves supply Trapezius Ischial pa of sciatic nerve and the obturator nerve supply adductor magnus Ref: Gray's 39e/p112-127

Digastric

Thyrohyoid

Trapezius

Adductor magnus

Anatomy

General anatomy

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Clinical features of T.B. Spine are AJE -

There is weight loss (not gain). The presenting complains are : - Back pain : Commonest and earliest symptom. Initially, pain occurs on the sudden movement of the spine. The stiffness of back : Is also an early symptom and occur along with pain. Visible deformity: Gibbus or Kyphosis Localized swelling : Due to cold abscess   Paraplagia : In neglected cases Constitutional symptoms : Evening fever, loss of appetite, night sweat, loss of weight. On examination, following findings may be seen : - Decreased range of motion. Local tenderness : Over the spinous process of an affected vertebra. Deformity : - Cervical spine : - Straight neck with loss of cervical lordosis. Thoracic : - Gibbus/kyphosis Lumbar : - Loss of lumbar lordosis        iv) Para-vertebral swelling : - Cold abscess

Loss of lordosis

Night sweats

Weight gain

Evening rise of temperature

Orthopaedics

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Inheritance pattern of ABO blood group system and HLA system

"The genes that determine the A and B phenotypes are found on chromosome 9p and are expressed in a Mendelian codominant manner."

Pseudodominance

Autosomal dominant

Autosomal recessive

Codominant

Pathology

All India exam

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single

Paroxymal sneezing on getting up early in morning from bed is associated with ?

Vasomotor Rhinitis It is a non allergic rhinitis clinically simulating nasal allergy. Symptoms Paroxysmal sneezing : Bouts of sneezing sta just after getting out of the bed in the morning. Excessive rhinorrhoea : This accompanies sneezing and may be the only predominant symptom. It is profuse and watery and may even wet several handkerchiefs. The nose may drip when the patient leans forward, and this may need to be differentiated from CSF rhinorrhoea. Nasal obstruction : This alternates from side to side. Usually more marked at night. It is the dependent side of nose which is often blocked when lying on one side. Postnasal drip.

Vasomotor rhinitis

Perineal rhinitis

Seasonal rhinitis

Allergic rhinitis

ENT

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multi

A young male patient presented with UTI. On urine examination pus cells were found but no organisms. Which method would be best for culture?

Sterile pyuria -caused by Chlamydia , ureaplasma and mycoplasma. McCoy culture is used for Chlamydia. Thayer Main - Neisseria gonorrhea. L J medium - Mycobacterium tuberculosis Levinthal medium - Hemophilus

Mc Coy culture

Thayer Main medium

L.J medium

Levinthal medium

Microbiology

All India exam

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single

In the life cycle of malaria parasite, the definitive host is -

Life history of plasmodium The malaria parasite undergoes 2 cycles of development the human cycle (asexual cycle) and the mosquito cycle (sexual cycle). Man is the intermediate host and mosquito the definitive host Ref: Park 25th edition Pgno : 281-285

Mosquito

Man

Pig

Sandly

Social & Preventive Medicine

Communicable diseases

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What is this study?

Retrograde ureterogram demonstrating the collecting system. The radiolucent filling defect in the renal pelvis is caused by radiolucent calculus

Retrograde Pyelogram

Ultrasound

X Ray KUB

Contrast CT KUB

Surgery

Urology

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single

Maximum number of oogonia is seen at

Maximal number of oogonia is achieved at 20th week of gestation.

Puberty

20th week of gestation

At birth

20 years age

Gynaecology & Obstetrics

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single

All of the following are functions of the spleen EXCEPT ?

Functions of spleen:- 1. Phagocytic function -- when any foreign body invades, macrophages ingest them by phagocytosis & liberate the antigenic products of the organism -- antigens activate the helper T lymphocytes & B lymphocytes 2. Secretion of bactericidal agents -- secrete many bactericidal agents which kill the bacteria I. Superoxide (02-) II. Hydrogen peroxide (H202) III. Hydroxyl ions (OH -) 3. Secretion of interleukins -- IL-1: accelerate maturation & proliferation of specific B lymphocytes & T lymphocytes -- IL-6: cause growth of B lymphocytes -- IL-12: influence the T-helper cells Through the reticuloendothelial system the spleen clears encapsulated bacteria such as pneumococcus and Haemophilus influenzae which are poorly opsonized from the hepatic reticuloendothelial system. In addition to these functions the spleen serves as an extramedullary site for hematopoiesis and plays a functional role in the recycling of iron. While the white pulp of the spleen is impoant in the initiation of the adaptive immune response, material is delivered to the spleen through the blood and not the lymph.

Clearance of damaged or aged red blood cells (RBCs) from the blood.

Extramedullary site for hematopoiesis and recycling iron.

Initiation of adaptive immune response from filtration of lymph.

Clearance of encapsulated bacteria from the bloodstream.

Surgery

Spleen

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Sandifer syndrome due to GERD in infants is confused with __________

Infants with GERD presents with anorexia, dysphagia, arching of back during feedings, irritability, hematemesis, anaemia, failure to thrive.other symptoms are chest pain, recurrent pneumonia apnoea, wheezing, stridor, hoarseness, cough, abnormal neck posturing(Sandifer syndrome) Sandifer syndrome is most commonly mistaken for seizures Ref : ESSENTIAL PEDIATRICS,O.P.GHAI, PG NO:253, 7th edition

Seizures

Recurrent vomiting

Acute otitis media

Sinusitis

Pediatrics

Gastrointestinal tract

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single

Witches chin is not associated with?

Ptosis of mentalis muscle

Long term edentulous mandible without denture

Loss of muscle attachment

Increased vertical dimensions

Dental

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single

Inferior orbital fissure is between which 2 walls of orbit:

Inferior orbital fissure is formed between the greater wing of the sphenoid (lateral wall) and maxilla (Floor)runs posterolaterally It transmits the zygomatic branch of the maxillary nerve and the ascending branches from the pterygopalatine ganglion The infraorbital vessels are found in the inferior orbital fissure and travel down the infraorbital groove into the infraorbital canal and exit through the infraorbital foramen Inferior division of ophthalmic vein passes through the inferior orbital fissure. No. 6 is Inferior Orbital fissure No. 3 is Superior Orbital fissure

Roof and medial

Lateral and floor

Floor and medial

Roof and lateral

Ophthalmology

Ocular Embryology& Anatomy

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multi

In a family, mother is normal while father has a genetic disease. All their daughters are carriers and sons are normal, what is the pattern of inheritance of disease?

a. X-linked recessive(Ref: Nelson's 20/e p 595, Ghai 8/e p 640)In a X-linked recessive disease; affected male transmits the disorder to all his daughters (carriers)Sons get their X chromosome from their mother & not from their fatherHence sons of a diseased father are unaffected in X-linked diseasesIn an X-linked dominant disorder all the daughters of an affected father would be diseased and not carriers.

X-linked recessive

X-linked dominant

AD

AR

Pediatrics

Genetics And Genetic Disorders

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multi

The blood gas parameters: pH 7.58, pCo2 23 mm Hg pO2 300 mm Hg and oxygen saturation 60% are most consistent with-

Answer is B (Ventilatory malfunction) Ventilatory malfunction is the single best answer of exclusion This is consistent with a diagnosis of ventilatory mal function. None of the other three condition satisfy the given parameters of the patients. The answer of exclusion therefore is some form of ventilatory malfunction. In carbon monoxide poisoning ABG analysis would reveal acidosis and nollnal PO2 In voluntary hyperventilation oxygen saturation would be normal. In methyl alcohol poisoning ABG would reveal acidosis and not alkalosis.

Carbon monoxide poisoning

Ventilatory malfunction

Voluntary hyperventilation

Methyl alcohol poisoning

Medicine

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single

A 21 year old male presents with anemia and mild hepatosplenomegaly. His hemoglobin is 5 gm/dit, history of single blood transfusion is present till date. Most probable diagnosis is -

Thalassemia major

Thalassemia minor

Thalassemia intermedia

Autoimmune hemolytic anemia

Medicine

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Cause of alpha thalasemia -

Ans. is 'a' i.e., Deletion of alpha genes a thalassemiasAlpha thalassemias are hemoglobin disorders in which the a chain of the hemoglobin is not/partly synthesized. a chains are required for all types of hemoglobin synthesis of all types of hemoglobin i.e.HbA (a2 b2)HbF (a2 g2)* HbA2 (a2d2)

Deletion of alpha genes

Deletion of beta genes

Excess of alpha genes

Single amino acid substitution in alpha chain

Medicine

Thalassemia

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single

Which of the following is/are feature of streptococcus agalactiae rather than staphylococcus aureus?

C. Coagulase negativeb hemolysis and bacitracin resistance occur in bothStaphylococcus AureusCoagulase Positive: Ananthanarayan Whf2l0Beta type of hemolyisis on blood agar-Microbiology by Baveja 5th/175"Streptococci- coagulase negative" Ananthanarayan lQ7h/218 "Lancefield group B consists of a single species, S. agalactiae, which is definitively identified with specific antiserum to the group B cell wall-associated carbohydrate antigen. A streptococcal isolate can be classified presumptively as GBS on the basis of biochemical tests, including hydrolysis of sodium hippurate (in which 99% of isolates are positive), hydrolysis of bile esculin (in which 99-100% are negative), bacitracin susceptibility (in which 92% are resistant), and production of CAMP factor (in which 98-100% are positive). CAMP factor is a phospholipase produced by GBS that causes synergistic hemolysis with p lysin produced by certain strains ofS. aureus'-Harrison 19th/969Staphylococci produce catalase, which converts hydrogen peroxide into water and oxygen. The catalase test differentiates the staphylococci, which are positive, from the streptococci, which are negative- Jawetz 27th/205Ananthanarayan 10th/210Species or common nameLancefield groupHemolysisLaboratory testS. pyogenesABetaBacitracin-sensitive, PYR test-positive; Ribose not fermntedS. agalactiaeBBetaCAMP test, Hippurate hydrolysisBacitracin Test microbeonline.com Positive: Streptococcus pyogenes Negative: Streptococcus agalactiaeThe bacitracin test is useful for differentiating b-hemolytic Group A streptococci from b-hemolytic non-Group A streptococci. This is important because most streptococcal diseases are caused by Group A streptococci. The bacitracin test can also be used to differentiate the bacitracin-resistant Staphylococcus from the bacitracin-susceptible Micrococcuswww.austincc.edu

Catalase positive

Bacitracin resistant

Coagulase negative

a hemolysis

Microbiology

Bacteria

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single

A neonate diagnosed of having pentalogy of Fallot. She may have the following lesions:

Patients with tetralogy of Fallot have a VSD, RV infundibular stenosis, RVH, and a dilated aoa (in about 50% of patients it overrides the septum). If there is an associated ASD, the complex is referred to as pentalogy of Fallot. Ref: Bashore T.M., Granger C.B., Hranitzky P., Patel M.R. (2013). Chapter 10. Hea Disease. In M.A. Papadakis, S.J. McPhee, M.W. Rabow (Eds), CURRENT Medical Diagnosis & Treatment 2013.

TOF + PDA

TOF + ASD

TOF + COA

TOF + Polysplenia

Pediatrics

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multi

Methadone is used to treat withdrawal symptoms of: PGI 12; NEET 13

Ans. Heroin

Cocaine

Heroin

Amphetamine

Barbiturate

Forensic Medicine

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single

Carbamoyl phosphate synthase I is used in ?

Ans. is 'c' i.e., Urea cycleCarbamyl phosphate synthase I Urea cycleCarbamyl phosphate synthase II- Pyrimidine synthesis

Purine synthesis

Pyrimidine synthesis

Urea cycle

Uronic acid pathway

Biochemistry

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single

In which of the following types of leukemia is methotrexate administered for CNS prophylaxis -

ALL

AML

CLL

CML

Medicine

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multi

Features of Mitral stenosis on X-ray are all EXCEPT:

Lower lobe prominence of veins REF: Sutton's radiology 7th edition page 294 Features of mitral stenosis on X ray: Straightening of hea border (earliest sign ) Lifting of left bronchus Posterior displacement of esophagus Double atrial shadow Alveolar edema Kerly B lines Pulmonary hemosiderosis Cephalisation of upper lobe vessels Moustache sign: Enlargement of main pulmonary aery and periferal pruning

Double contour of right border

Lifting of left mainbronchus

Splaying of carinal angle

Lower lobe prominence of veins

Radiology

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multi

Medical etiquette is related to

Medical etiquette:- It deals with the conventional laws of couesy observed between members of the medical profession. A doctor should behave with his colleagues as he would have them behave with himself. Medical jurisprudence (juris= law; prudentia = knowledge):- It deals with legal responsibilities of the physician with paicular reference to those arising from physician-patient relationship, such as medical negligence cases, consent, rights and duties of doctors, serious professional misconduct, medical ethics, etc. In sho, it deals with legal aspects of practice of medicine. Ref:- k s narayan reddy; pg num:-01

Moral principles followed by doctors

Legal responsibilities of doctors

Couesy observed between doctors

Rules to be followed by doctors

Forensic Medicine

Medico legal procedures

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single

Because free ammonia in the blood is toxic to the body, it is transported in which of the following non-toxic forms?

Ans. C. Glutamine and ureaBoth urea and glutamine play an important role in the storage and transport of ammonia in the blood. Histidine, phenylalanine, methionine, and lysine are not involved in ammonia transport.

Histidine and urea

Phenylalanine and methionine

Glutamine and urea

Lysine and glutamine

Physiology

Misc.

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single

Which one of the following structures is pa of the diencephalon?

Diencephalon consist of:- Thalamus Hypothalamus Meta-thalamus-include medial and lateral geniculate body Epi-thalamus-include Pineal body, Habenular trigone and post. commisure Sub-thalamus

Caudate nucleus

Cerebral hemispheres

Hippocampus

Thalamus

Anatomy

Neuroanatomy 3

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single

One of the most common complication of iridocyclitis is:

Ans. Secondary glaucoma

Scleritis

Secondary glaucoma

Band-shaped keratopathy

Corneal ulcer

Ophthalmology

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single

About retinitis pigmentosa, all are true EXCEPT: September 2012

Ans. B i.e. Central scotoma Retinitis pigmentosa Feature: Loss of visual acuity Microscopy: Irregular black deposits of clumped pigment in the peripheral retina (Bone spicules)

Ring scotoma

Central scotoma

Waxy pallor of disc

Bone spicule pigmentation in retina

Ophthalmology

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multi

Most common carcinoma after burns is:

Squamous cell carcinoma is MC carcinoma in burns. SCC commonly occurs in long standing ( Marjolin's ulcer) , old scar or keloid. Both Marjolin's ulcer & keloid are complications that arise after burns

Squamous cell carcinoma

Adenocarcinoma

Melanoma

Mucoid carcinoma

Surgery

Burns

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single

Which of the following cells do not act as antigen presenting cells. ?-

Answer is option 1 T cell responses differ from B cell responses in at least two crucial ways. First, T cells are activated by foreign antigen to proliferate and differentiate into effector cells only when the antigen is displayed on the surface of antigen-presenting cells in peripheral lymphoid organs. The T cells respond in this manner because the form of antigen they recognize is different from that recognized by B cells. Whereas B cells recognize intact antigen, T cells recognize fragments of protein antigens that have been paly degraded inside the antigen-presenting cell. The peptide fragments are then carried to the surface of the presenting cell on special molecules called MHC proteins, which present the fragments to T cells. T cells don't act as antigen presenting cells.

T-cells

B-cells

Macrophages

Osteoclasts

Pathology

General pathology

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single

Commonest cause of obstructive hydrocephalus in children

Aqueducts stenosis is most common cause of obstructive hydrocephalus in children. Reference: GHAI Essential pediatrics, 8th edition

Acqueductal stenosis

Aquaductal gliosis

Subarachnoid hemorrhage

Tubercular meningitis

Pediatrics

Central Nervous system

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single

Characteristic feature of acute inflammation is:

. Vasodilatation and increased vascular permeability

Vasoconstriction

Vascular stasis

Vasodilatation and increased vascular permeability

Margination of leucocytes

Pathology

3c8e7bec-2dc7-4add-a915-3e15a0de0444

single

According to FIGO classification the investigation in Carcinoma cervix are all except -

Ans-C

X-Ray Chest

IVP

Pelvic ultrasound

Cystoscopy

Unknown

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multi

Most specific marker for neural tube defects is

Both alpha-fetoprotein and acetylcholinesterase in amniotic fluid are markers for neural tube defects. But acetylcholinesterase is the most specific marker. Ref : Dutta book of obstetrics 8th Ed

Alpha-fetoprotein

Unconjugated estriol

Acetylcholinesterase

Pseudocholinesterase

Gynaecology & Obstetrics

All India exam

777e4501-6a4a-418c-8059-d38880722d15

single

The most dreadful complication of Kawasaki disease is

Kawasaki disease is an acute, febrile, usually self-limited illness of infancy and childhood (80% of the patients are younger than 4 years of age) associated with an aeritis of mainly large to medium-sized vessels. Its clinical significance stems from the involvement of coronary aeries. Coronary aeritis can cause aneurysms that rupture or thrombose, resulting in myocardial infarction. (Robbins basic pathology,9th edition,pg no.352)

Rash

Lymph node

Cardiac involvement

Thrombocytosis

Pathology

Cardiovascular system

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single

Anaplasia is:

Ans. c. Lack of differentiationRef: Robbins and Cotran Pathologic Basis of Disease 9th Ed; Page No-269Cellular ChangesHyperplasia: Increase in number of cells. May be a risk factor for future malignancy (e.g. to endometrial hyperplasia) but not considered premalignant.Hypertrophy: Increase in size of cells.Atrophy: Decrease in tissue mass due to increase in size and/or number of cells. Causes include disuse, denervation, loss of blood supply, loss of hormonal stimulation, poor nutrition.Dysplasia: Disordered, non-neoplastic cell growth. Term used only with epithelial cells. Mild dysplasia is usually reversible; severe dysplasia usually progresses to carcinoma in situ.Metaplasia: Replacement of one cell type by another. Usually due to exposure to an irritant, such as gastric acid or cigarette smoke. Reversible if the irritant is removed but may undergo malignant transformation with persistent insult (e.g. Barrett esophagus - esophageal adenocarcinoma).Neoplasia: Uncontrolled, clonal proliferation of cells. Can be benign or malignant.Anaplasia: Complete lack of differentiation of cells in a malignant neoplasm.Differentiation The degree to which a malignant tumor resembles its tissue of origin:Well-differentiated tumors (often less aggressive) closely resemble their tissue of origin.Poorly differentiated tumors (often more aggressive) look almost nothing like their tissue of origin.

Changing one type of epithelium to another

Nuclear chromatin

Lack of differentiation

Morphological changes

Pathology

Neoplasia

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single

Which of the following is not an indication ofcotrimoxazole aEUR'

Chancroid Corimoxazole in Typhoid Initially cotrimoxazole was an effective alternative to chloramphenicol. However, in many areas resistant S. typhi have appeared and now it is seldom used. Cotrimoxazole in chancroid Corimoxazole for 7 days is a 3rd choice inexpensive alternative to ceftriaxone, erythromycin or iprofloxacin. Cotrimoxazole It is a combination of sulfonamide (sulfamethoxazole) and trime- thoprim in the ratio of 1 :5. Cotrimoxazole was claimed to be more effective than either of its components individually in treating bacterial infections. Because of its associated greater incidence of adverse effects including allergic responses its widespread use has been restricted in many countries to very specific circumstances where its improved efficacy is demonstracted. Uses of Cotrimoxazole Upper and lower respiratory tract infections - Exacerbations of chronic bronchitis - For otitis media and sinusitis. - It should never be used for streptococcal pharyngitis. Urinary tract infections -Uncomplicated cystitis in non pregnant women. Especially valuable for chronic and recurrent cases. - Prostatitis (cotrimoxazole is concentrated in goodamounts in prostate) Pneumocystic carinii pneumonia -Drug of choice next to pentamidine for the treatment and prophylaxis of pneumonias caused by Pneumocystic Jirovecci (commonly seen in imtnunocompromised patients including those suffering from HIV/AIDS). Other conditions where cotrimoxazole finds its use. -Listeria monocytogens infections - Meliodosis - Shigellosis - Traveller's diarrhoeas (E. coli, Campylobacter, Shigella, Y. enterocolitica) - Prophylaxis of cerebral toxoplasmosis - Whipple's disease - Salmonella (typhoid) initially it was responsive but now resistant strains have emerged. - Chancroid According to K.D.T. - Cotrimoxaxole can be used in both chancroid and typhoid. According to Harrison (18/e) Cotrimoxazole is used in Typhoid but it is not used in chancroid. Antiobiotic therapy in typhoid Empirical Ceftriaxone Azithromycin Fully susceptible Ciprofloxacin Amoxicillin Chloramphenicol Cotritnoxazole Multidrug resistant Ciprofloxacin Ceftriaxonl Azithromycin Nalidixic acid resistant Ceftriaxone Azithromycin High dose ciprofloxacin Treatment of chancroid Ciprofloxacin Ceftriaxone Azithromycin

>Lower UTI

>Prostatitis

>Chancroid

>Typhoid

Pharmacology

bace2c54-6e9c-41be-a415-3e72d4de49c4

single

Relationship between nerve thickness and conduction velocity of myelinated nerves is:

Fiber diameter (thickness) and conduction velocity relationship:  The relationship is linear  for  myelinated  axons  and  parabolic relation for non­myelinated axons.

Linear

Parabolic

Hyperbolic

No relation

Physiology

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single

A six-year old boy is schedules for examination of the eye under anaesthesia. The father informed that for the past six months the child is developing progressive weakness of both legs. His elder sibling had died at the age of 14 years. Which drug would you definitely avoid during the anaeshetic management?

A i.e. Succinylcholine Boy is having some myopathy (probably duchenne's). So Sch may lead to life threatening hyperkalemia.

Succinylcholine

Thiopentone

Nitrous oxide

Vecuronium

Anaesthesia

2b5ac590-8591-41a5-9f78-b5544593fe91

multi

'hn RNA' is associated with which of the following heamatological condition?

hn RNA is seen in case of splicing defect. It is also seen in spiral muscular atropy.

a - Thalassemia

Sickle cell anaemia

B - Thalassemia

None

Biochemistry

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Virchow's cells are seen in –

Foam cells containing lepra bacilli are called virchow's cells (lepra cells). These cells are abundant in lepromatous leprosy.

Henoch scholein purpura

Toxic Epidermal necrolysis

Congenital syphilis

Leprosy

Dental

5d2df81e-9e1f-4701-947e-7750ef5c79cf

single

Following statements are true with respect to glycogen except

Insulin inhibits glycogenolysis by oring the inactivation of glycogen phosphorylase and inhibiting glucose-6-phosphatase. The net effect of all these three mechanisms, blood glucose level is lowered.Ref: DM Vasudevan, 7th edition, page no: 321

Principle storage of carbohydrate in the human body is glycogen

Liver and muscle are the main sites of glycogen storage

Produced by glycogenesis

Insulin stimulates glycogenolysis

Biochemistry

Metabolism of carbohydrate

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