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BioInfer.d801.s0
[ { "id": "BioInfer.d801.s0__text", "type": "Sentence", "text": [ "We determined whether short-term weight-lifting exercise increases the synthesis rate of the major contractile proteins, myosin heavy chain (MHC), actin, and mixed muscle proteins in nonfrail elders and younger women and men." ], "offsets": [ [ 0, 225 ] ] } ]
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[]
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868
BioInfer.d802.s0
[ { "id": "BioInfer.d802.s0__text", "type": "Sentence", "text": [ "We examined whether levels of alpha-smooth-muscle actin or proliferating cell nuclear antigen correlated with myosin heavy-chain levels in the glomeruli of rats with puromycin aminonucleoside nephrosis." ], "offsets": [ [ 0, 202 ] ] } ]
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869
BioInfer.d803.s0
[ { "id": "BioInfer.d803.s0__text", "type": "Sentence", "text": [ "We find that profilin and cofilin regulate actin-filament formation throughout the cell cortex." ], "offsets": [ [ 0, 95 ] ] } ]
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870
BioInfer.d804.s0
[ { "id": "BioInfer.d804.s0__text", "type": "Sentence", "text": [ "We find that profilin contributes in several ways to Cdc42-induced nucleation of actin filaments in high speed supernatant of lysed neutrophils." ], "offsets": [ [ 0, 144 ] ] } ]
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871
BioInfer.d805.s0
[ { "id": "BioInfer.d805.s0__text", "type": "Sentence", "text": [ "We found normal levels of alpha-catenin and beta-catenin in BT549 and HS578t cells; however, low levels of plakoglobin were expressed in these cells compared to those found in weakly invasive MCF-7 cells." ], "offsets": [ [ 0, 204 ] ] } ]
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[]
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872
BioInfer.d807.s0
[ { "id": "BioInfer.d807.s0__text", "type": "Sentence", "text": [ "We have analyzed the expression levels of the genes encoding alpha-catenin, beta-catenin and plakoglobin in correlation to the E-cadherin expression levels in cell lines derived from human cervical carcinomas." ], "offsets": [ [ 0, 209 ] ] } ]
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873
BioInfer.d809.s0
[ { "id": "BioInfer.d809.s0__text", "type": "Sentence", "text": [ "We have characterized this actin with respect to its ability to interact with yeast profilin and tropomyosin, the only yeast actin-binding proteins so far purified and characterized." ], "offsets": [ [ 0, 182 ] ] } ]
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874
BioInfer.d809.s1
[ { "id": "BioInfer.d809.s1__text", "type": "Sentence", "text": [ "Yeast profilin can sequester yeast actin monomers and thereby reduce the ability of yeast actin to polymerize, whereas it has little effect on the degree of polymerization of rabbit skeletal muscle actin." ], "offsets": [ [ 0, 204 ] ] } ]
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875
BioInfer.d810.s0
[ { "id": "BioInfer.d810.s0__text", "type": "Sentence", "text": [ "We have cloned a Saccharomyces cerevisiae gene (COF1) encoding a low-M(r) actin-binding protein of 143 amino acid (aa) residues (yeast cofilin; Cof); its aa sequence is 35% identical to porcine Cof." ], "offsets": [ [ 0, 198 ] ] } ]
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876
BioInfer.d812.s0
[ { "id": "BioInfer.d812.s0__text", "type": "Sentence", "text": [ "We have examined the level of cyclin E, a G1 cyclin, and p27kip, a cyclin-dependent kinase inhibitor, in BALB/c 3T3 cells." ], "offsets": [ [ 0, 122 ] ] } ]
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877
BioInfer.d813.s0
[ { "id": "BioInfer.d813.s0__text", "type": "Sentence", "text": [ "We have found that cofilin, a 21-kDa actin-binding protein, is a component of these rods." ], "offsets": [ [ 0, 89 ] ] } ]
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878
BioInfer.d814.s0
[ { "id": "BioInfer.d814.s0__text", "type": "Sentence", "text": [ "We have shown that the FH proteins Bni1p and Bnr1p are potential targets of the Rho family small GTP-binding proteins and bind to an actin-binding protein, profilin, at their proline-rich FH1 domains to regulate reorganization of the actin cytoskeleton in the yeast Saccharomyces cerevisiae." ], "offsets": [ [ 0, 291 ] ] } ]
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[]
[]
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879
BioInfer.d815.s0
[ { "id": "BioInfer.d815.s0__text", "type": "Sentence", "text": [ "We have shown that these proteins are indeed nuclear basic proteins: the 14 kd is the histone H4, the 19 kd is the histone H3, and the 25 kd is the sperm-specific protein SP2." ], "offsets": [ [ 0, 175 ] ] } ]
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880
BioInfer.d817.s0
[ { "id": "BioInfer.d817.s0__text", "type": "Sentence", "text": [ "We previously showed that actin is transported in an unassembled form with its associated proteins actin depolymerizing factor, cofilin, and profilin." ], "offsets": [ [ 0, 150 ] ] } ]
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[]
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881
BioInfer.d819.s0
[ { "id": "BioInfer.d819.s0__text", "type": "Sentence", "text": [ "We report here that tropomyosin, which is found in the rootlet but not in the microvillus core, can bind to and saturate the actin of isolated cores, and can cause the dissociation of up to 30% of the villin and fimbrin from the cores but does not affect actin binding by 110-kD calmodulin." ], "offsets": [ [ 0, 290 ] ] } ]
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[]
[]
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882
BioInfer.d821.s0
[ { "id": "BioInfer.d821.s0__text", "type": "Sentence", "text": [ "We show that the HSV-1 UL5, UL8, UL29, UL30, UL42, and UL52 gene products along with the AAV Rep68 protein are sufficient to initiate replication on duplex DNA containing the AAV origins of replication, resulting in products several hundred nucleotides in length." ], "offsets": [ [ 0, 263 ] ] } ]
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[]
[]
[]
883
BioInfer.d822.s0
[ { "id": "BioInfer.d822.s0__text", "type": "Sentence", "text": [ "We speculate that fimbrin may help maintain the parallel growth of actin filaments within the stereocilia." ], "offsets": [ [ 0, 106 ] ] } ]
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[]
[]
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884
BioInfer.d823.s0
[ { "id": "BioInfer.d823.s0__text", "type": "Sentence", "text": [ "Western analysis of gel-purified USF-nucleosome and GAL4-AH-nucleosome complexes demonstrated the predominant presence of acetylated histone H4 relative to acetylated histone H3." ], "offsets": [ [ 0, 178 ] ] } ]
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[]
[]
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885
BioInfer.d827.s0
[ { "id": "BioInfer.d827.s0__text", "type": "Sentence", "text": [ "We then compared colorectal cancers with 'mild' RER (n = 15), and those with 'severe' RER without (n = 11) or with (n = 22) detectable mutations in MSH2 or MLH1 to assess the involvement of mononucleotide repeats contained in the coding regions of MSH3, MSH6, BAX, and TGFbeta RII." ], "offsets": [ [ 0, 281 ] ] } ]
[ { "id": "BioInfer.d827.s0.e0", "type": "Gene/protein/RNA", "text": [ "MSH2" ], "offsets": [ [ 148, 152 ] ], "normalized": [] }, { "id": "BioInfer.d827.s0.e1", "type": "Gene/protein/RNA", "text": [ "MSH3" ], "offsets": [ [ 248, 252 ] ], "normalized": [] }, { "id": "BioInfer.d827.s0.e2", "type": "Gene/protein/RNA", "text": [ "MLH1" ], "offsets": [ [ 156, 160 ] ], "normalized": [] }, { "id": "BioInfer.d827.s0.e3", "type": "Gene/protein/RNA", "text": [ "BAX" ], "offsets": [ [ 260, 263 ] ], "normalized": [] }, { "id": "BioInfer.d827.s0.e4", "type": "Gene/protein/RNA", "text": [ "MSH6" ], "offsets": [ [ 254, 258 ] ], "normalized": [] }, { "id": "BioInfer.d827.s0.e5", "type": "Gene/protein/RNA", "text": [ "TGFbeta RII" ], "offsets": [ [ 269, 280 ] ], "normalized": [] } ]
[]
[]
[]
886
BioInfer.d828.s0
[ { "id": "BioInfer.d828.s0__text", "type": "Sentence", "text": [ "We used yeast as a model to test this hypothesis and found that chromosome deletion of any known nuclear mitotic mismatch repair genes, including MLH1, MSH2, MSH3, MSH6, and PMS1, did not rescue mgt1delta O6 MeG DNA repair methyltransferase-deficient cells from killing by MNNG." ], "offsets": [ [ 0, 278 ] ] } ]
[ { "id": "BioInfer.d828.s0.e0", "type": "Gene/protein/RNA", "text": [ "methyltransferase" ], "offsets": [ [ 223, 240 ] ], "normalized": [] }, { "id": "BioInfer.d828.s0.e1", "type": "Gene/protein/RNA", "text": [ "mgt1" ], "offsets": [ [ 195, 199 ] ], "normalized": [] }, { "id": "BioInfer.d828.s0.e2", "type": "Gene/protein/RNA", "text": [ "MSH6" ], "offsets": [ [ 164, 168 ] ], "normalized": [] }, { "id": "BioInfer.d828.s0.e3", "type": "Gene/protein/RNA", "text": [ "PMS1" ], "offsets": [ [ 174, 178 ] ], "normalized": [] }, { "id": "BioInfer.d828.s0.e4", "type": "Gene/protein/RNA", "text": [ "MSH2" ], "offsets": [ [ 152, 156 ] ], "normalized": [] }, { "id": "BioInfer.d828.s0.e5", "type": "Gene/protein/RNA", "text": [ "MSH3" ], "offsets": [ [ 158, 162 ] ], "normalized": [] }, { "id": "BioInfer.d828.s0.e6", "type": "Gene/protein/RNA", "text": [ "MLH1" ], "offsets": [ [ 146, 150 ] ], "normalized": [] } ]
[]
[]
[]
887
BioInfer.d829.s0
[ { "id": "BioInfer.d829.s0__text", "type": "Sentence", "text": [ "When a lyophilized Mf and AO mixture was incubated at 40 degrees C and 65% relative humidity, the conjugation of AO was confirmed at myosin heavy chain, actin, and tropomyosin." ], "offsets": [ [ 0, 176 ] ] } ]
[ { "id": "BioInfer.d829.s0.e0", "type": "Gene/protein/RNA", "text": [ "tropomyosin" ], "offsets": [ [ 164, 175 ] ], "normalized": [] }, { "id": "BioInfer.d829.s0.e1", "type": "Gene/protein/RNA", "text": [ "actin" ], "offsets": [ [ 153, 158 ] ], "normalized": [] }, { "id": "BioInfer.d829.s0.e2", "type": "Gene/protein/RNA", "text": [ "myosin heavy chain" ], "offsets": [ [ 133, 151 ] ], "normalized": [] } ]
[]
[]
[]
888
BioInfer.d830.s0
[ { "id": "BioInfer.d830.s0__text", "type": "Sentence", "text": [ "When the actin monomer pool in untransfected myoblasts is increased 70% by treatment with latrunculin A, synthesis of ADF and actin are down-regulated compared with cofilin and 19 other proteins selected at random." ], "offsets": [ [ 0, 214 ] ] } ]
[ { "id": "BioInfer.d830.s0.e0", "type": "Gene/protein/RNA", "text": [ "ADF" ], "offsets": [ [ 118, 121 ] ], "normalized": [] }, { "id": "BioInfer.d830.s0.e1", "type": "Gene/protein/RNA", "text": [ "cofilin" ], "offsets": [ [ 165, 172 ] ], "normalized": [] }, { "id": "BioInfer.d830.s0.e2", "type": "Gene/protein/RNA", "text": [ "actin" ], "offsets": [ [ 9, 14 ] ], "normalized": [] }, { "id": "BioInfer.d830.s0.e3", "type": "Gene/protein/RNA", "text": [ "actin" ], "offsets": [ [ 126, 131 ] ], "normalized": [] } ]
[]
[]
[]
889
BioInfer.d831.s0
[ { "id": "BioInfer.d831.s0__text", "type": "Sentence", "text": [ "While levels of most of these proteins decrease, accumulation of cyclin D1 and the cyclin-dependent kinase inhibitor p21 Cip1/WAF1 is observed." ], "offsets": [ [ 0, 143 ] ] } ]
[ { "id": "BioInfer.d831.s0.e0", "type": "Individual_protein", "text": [ "WAF1" ], "offsets": [ [ 126, 130 ] ], "normalized": [] }, { "id": "BioInfer.d831.s0.e1", "type": "Individual_protein", "text": [ "p21" ], "offsets": [ [ 117, 120 ] ], "normalized": [] }, { "id": "BioInfer.d831.s0.e2", "type": "Gene/protein/RNA", "text": [ "cyclin D1" ], "offsets": [ [ 65, 74 ] ], "normalized": [] }, { "id": "BioInfer.d831.s0.e3", "type": "Protein_family_or_group", "text": [ "cyclin-dependent kinase inhibitor" ], "offsets": [ [ 83, 116 ] ], "normalized": [] }, { "id": "BioInfer.d831.s0.e4", "type": "Individual_protein", "text": [ "Cip1" ], "offsets": [ [ 121, 125 ] ], "normalized": [] } ]
[]
[]
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890
BioInfer.d832.s0
[ { "id": "BioInfer.d832.s0__text", "type": "Sentence", "text": [ "While poly(ADP-ribose) effectively competed with DNA for binding of histone H4, it equally competed with DNA for binding of histone H3 and only inefficiently competed with DNA for binding of histone H1." ], "offsets": [ [ 0, 202 ] ] } ]
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[]
[]
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891
BioInfer.d833.s0
[ { "id": "BioInfer.d833.s0__text", "type": "Sentence", "text": [ "Within 1 hour of raising the concentration of calcium ions, integrins, cadherins, alpha-catenin, beta-catenin, plakoglobin, vinculin and alpha-actinin appeared to accumulate at cell-cell borders, whereas the focal contact proteins, paxillin and talin, did not." ], "offsets": [ [ 0, 260 ] ] } ]
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[]
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892
BioInfer.d834.s0
[ { "id": "BioInfer.d834.s0__text", "type": "Sentence", "text": [ "Within the sieve-tube exudate, profilin was present in 15-fold molar excess to actin." ], "offsets": [ [ 0, 85 ] ] } ]
[ { "id": "BioInfer.d834.s0.e0", "type": "Gene/protein/RNA", "text": [ "profilin" ], "offsets": [ [ 31, 39 ] ], "normalized": [] }, { "id": "BioInfer.d834.s0.e1", "type": "Gene/protein/RNA", "text": [ "actin" ], "offsets": [ [ 79, 84 ] ], "normalized": [] } ]
[]
[]
[]
893
BioInfer.d835.s0
[ { "id": "BioInfer.d835.s0__text", "type": "Sentence", "text": [ "YACs containing color vision red pigment gene DNA or 1.5 rDNA tandem repeat units were transformed into hosts bearing lesions at the RAD1, RAD6, RAD51, or RAD52 loci." ], "offsets": [ [ 0, 166 ] ] } ]
[ { "id": "BioInfer.d835.s0.e0", "type": "Gene/protein/RNA", "text": [ "RAD52" ], "offsets": [ [ 155, 160 ] ], "normalized": [] }, { "id": "BioInfer.d835.s0.e1", "type": "Gene/protein/RNA", "text": [ "color vision red pigment" ], "offsets": [ [ 16, 40 ] ], "normalized": [] }, { "id": "BioInfer.d835.s0.e2", "type": "Gene/protein/RNA", "text": [ "RAD6" ], "offsets": [ [ 139, 143 ] ], "normalized": [] }, { "id": "BioInfer.d835.s0.e3", "type": "Gene/protein/RNA", "text": [ "RAD51" ], "offsets": [ [ 145, 150 ] ], "normalized": [] }, { "id": "BioInfer.d835.s0.e4", "type": "Gene/protein/RNA", "text": [ "RAD1" ], "offsets": [ [ 133, 137 ] ], "normalized": [] } ]
[]
[]
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