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\begin{table} \centering \label{tab:tablelabel} \begin{tabular}{|l|l|l|l|l|} \hline \textbf{Variable} & \textbf{DrotAA n = 882} & \textbf{Non-DrotAA n = 11,610} & \textbf{Total n = 12,492} & \textbf{value P} \\ \hline Medical/Surgical Status, n (\%): & & & & <0.001 \\ \hline Medical & 540 (61.2) & 7232 (62.3) & 7772 (62.2) \\ \hline Surgical – Elective & 127 (14.4) & 1205 (10.4) & 1332 (10.7) \\ \hline Surgical – Emergency & 215 (24.4) & 3173 (27.3) & 3388 (27.1) \\ \hline SIRS criteria met, n (\%): & (n = 858) & (n = 11,241) & (n = 12099) & <0.001 \\ \hline 0 & 2 (0.2) & 29 (0.3) & 31 (0.3) \\ \hline 1 & 5 (0.6) & 188 (1.7) & 193 (1.6) \\ \hline 2 & 57 (6.6) & 1198 (10.7) & 1255 (10.4) \\ \hline 3 & 268 (31.2) & 4063 (36.1) & 4331 (35.8) \\ \hline 4 & 526 (61.3) & 5763 (51.3) & 6289 (52.0) \\ \hline Source of infection, n (\%): & (n = 856) & (n = 11,260) & (n = 12,116) & <0.001 \\ \hline Community acquired & 529 (61.8) & 6033 (53.6) & 6562 (54.2) \\ \hline Nosocomial – hospital acquired & 217 (25.4) & 3172 (28.2) & 3389 (28.0) \\ \hline Nosocomial – ICU acquired & 110 (12.9) & 2055 (18.3) & 2165 (17.9) \\ \hline Type of infection, n (\%): & (n = 675) & (n = 8380) & (n = 9055) \\ \hline \multirow{2}{*}{Gram negative} & 392 (58.1) & 4795 (57.2) & 5187 (57.3) & 0.67 \\ \hline (n = 681) & (n = 8396) & (n = 9077) \\ \hline \multirow{2}{*}{Gram positive} & 371 (54.5) & 3668 (43.7) & 4039 (44.5) & <0.001 \\ \hline (n = 682) & (n = 8678) & (n = 9360) \\ \hline Fungal & 103 (15.1) & 986 (11.4) & 1089 (11.6) & 0.003 \\ \hline Primary site of infection, n (\%): & (n = 861) & (n = 11,301) & (n = 12,162) & 0.35 \\ \hline Abdominopelvic & 227 (26.4) & 2642 (23.4) & 2869 (23.6) \\ \hline Bone or joint & 13 (1.5) & 160 (1.4) & 173 (1.4) \\ \hline Hematogenous & 59 (6.9) & 738 (6.5) & 797 (6.6) \\ \hline Indwelling catheter-dialysis access & 3 (0.3) & 79 (0.7) & 82 (0.7) \\ \hline Indwelling catheter-vascular access & 11 (1.3) & 163 (1.4) & 174 (1.4) \\ \hline Lung & 366 (42.5) & 5282 (46.7) & 5648 (46.4) \\ \hline Meninges & 12 (1.4) & 169 (1.5) & 181 (1.5) \\ \hline Skin or skin structure & 44 (5.1) & 586 (5.2) & 630 (5.2) \\ \hline Urinary tract & 71 (8.2) & 887 (7.8) & 958 (7.9) \\ \hline Other & 55 (6.4) & 595 (5.3) & 650 (5.3) \\ \hline \end{tabular} \end{table}
PMC2717475_table_1
\begin{table} \centering \label{tab:tablelabel} \begin{tabular}{|l|l|l|l|l|} \hline \textbf{Variable} & \textbf{DrotAA n = 882} & \textbf{Non-DrotAA n = 11,610} & \textbf{Total n = 12,492} & \textbf{P value} \\ \hline IV fluid resuscitation, n (\%) & (n = 782) 718 (91.8) & (n = 10,492) 9053 (86.3) & (n = 11,274) 9771 (86.7) & <0.001 \\ \hline Mechanical ventilation, n (\%) & (n = 882) 842 (95.5) & (n = 11,609) 9838 (84.7) & (n = 12,491) 10,680 (85.5) & <0.001 \\ \hline Vasopressors, n (\%) & (n = 882) 828 (93.9) & (n = 11,608) 9005 (77.6) & (n = 12,490) 9833 (78.7) & <0.001 \\ \hline Nutrition: \\ \hline Enteral, n (\%) & (n = 882) 678 (76.9) & (n = 11,588) 8369 (72.2) & (n = 12,470) 9047 (72.6) & 0.003 \\ \hline Parenteral, n (\%) & (n = 882) 383 (43.4) & (n = 11,601) 3726 (32.1) & (n = 12,483) 4109 (32.9) & <0.001 \\ \hline Heparin: \\ \hline Low molecular weight & (n = 871) 418 (48.0) & (n = 11,586) 3879 (33.5) & (n = 12,457) 4297 (34.5) & <0.001 \\ \hline Unfractionated & (n = 868) 345 (39.8) & (n = 11,601) 4628 (39.9) & (n = 12,469) 4973 (39.9) & 0.932 \\ \hline Steroids: \\ \hline Low dose & (n = 878) 499 (56.8) & (n = 11,559) 3994 (34.6) & (n = 12,437) 4493 (36.1) & <0.001 \\ \hline High dose & (n = 880) 156 (17.7) & (n = 11,600) 1397 (12.0) & (n = 12,480) 1553 (12.4) & <0.001 \\ \hline Mechanical VTE prophylaxis & (n = 765) 295 (38.6) & (n = 10,371) 2407 (23.2) & (n = 11,136) 2702 (24.3) & <0.001 \\ \hline Renal replacement therapy & (n = 876) 283 (32.3) & (n = 11,598) 2383 (20.6) & (n = 12,474) 2666 (21.4) & <0.001 \\ \hline Platelet transfusion & (n = 780) 178 (22.8) & (n = 10,483) 1677 (16.0) & (n = 11,263) 1855 (16.5) & <0.001 \\ \hline \end{tabular} \end{table}
PMC2717475_table_2
\begin{table} \centering \label{tab:tablelabel} \begin{tabular}{|l|l|l|l|l|} \hline \textbf{Variable} & \textbf{DrotAA n = 882} & \textbf{Non-DrotAA n = 11,610} & \textbf{Total n = 12,492} & \textbf{P value} \\ \hline Number of organ dysfunctions (OD): & (n = 703) & (n = 8910) & (n = 9613) & <0.001 \\ \hline 1 & 18 (2.6) & 1042 (11.7) & 1060 (11.0) \\ \hline 2 & 93 (13.2) & 1861 (20.9) & 1954 (20.3) \\ \hline 3 & 169 (24.0) & 2045 (23.0) & 2214 (23.0) \\ \hline 4 & 161 (22.9) & 1778 (20.0) & 1939 (20.2) \\ \hline 5 & 143 (20.3) & 1171 (13.1) & 1314 (13.7) \\ \hline 6 & 87 (12.4) & 677 (7.6) & 764 (8.0) \\ \hline 7 & 32 (4.6) & 336 (3.8) & 368 (3.8) \\ \hline Type of dysfunction, n (\%): \\ \hline Cardiovascular & (n = 882) 791 (89.7) & (n = 11,565) 8536 (73.8) & (n = 12,447) 9327 (74.9) & <0.001 \\ \hline Respiratory & (n = 880) 788 (89.5) & (n = 11,550) 9357 (81.0) & (n = 12,430) 10,145 (81.6) & <0.001 \\ \hline Hematologic & (n = 879) 314 (35.7) & (n = 11,475) 3773 (32.9) & (n = 12,354) 4087 (33.1) & 0.08 \\ \hline Renal & (n = 879) 523 (59.5) & (n = 11,480) 5117 (44.6) & (n = 12,359) 5640 (45.6) & <0.001 \\ \hline Hepatic & (n = 771) 150 (19.5) & (n = 10,188) 2111 (20.7) & (n = 10,959) 2261 (20.6) & 0.40 \\ \hline Metabolic & (n = 867) 542 (62.5) & (n = 11,266) 4745 (42.1) & (n = 12,133) 5287 (43.6) & <0.001 \\ \hline Central nervous system & (n = 767) 276 (36.0) & (n = 9987) 3686 (36.9) & (n = 10,754) 3962 (36.8) & 0.61 \\ \hline APACHE II score, mean ($\pm$ SD) & (n = 610) 25.6 ($\pm$ 8.5) & (n = 8513) 23.2 ($\pm$ 8.2) & (n = 9123) 23.4 ($\pm$ 8.3) & <0.001 \\ \hline Total SOFA score, mean ($\pm$ SD) & (n = 334) 10.3 ($\pm$ 3.4) & (n = 4785) 9.2 ($\pm$ 3.9) & (n = 5119) 9.3 ($\pm$ 3.9) & <0.001 \\ \hline Total MODS score, mean ($\pm$ SD) & (n = 171) 8.6 ($\pm$ 3.7) & (n = 2244) 6.4 ($\pm$ 3.6) & (n = 2415) 6.5 ($\pm$ 3.6) & <0.001 \\ \hline SAPS II score, mean ($\pm$ SD) & (n = 165) 50.2 ($\pm$ 18.5) & (n = 2831) 49.0 ($\pm$ 17.3) & (n = 2996) 49.1 ($\pm$ 17.4) & 0.48 \\ \hline \end{tabular} \end{table}
PMC2717475_table_3
\begin{table} \centering \label{tab:tablelabel} \begin{tabular}{|l|l|l|l|l|} \hline \textbf{Variable} & \textbf{DrotAA n = 882} & \textbf{Non-DrotAA n = 11,610} & \textbf{Total n = 12,492} & \textbf{P value} \\ \hline Diabetes, n (\%) & (n = 766) 164 (21.4) & (n = 10,352) 2441 (23.6) & (n = 11,118) 2605 (23.4) & 0.17 \\ \hline Chronic lung disease, n (\%) & (n = 870) 136 (15.6) & (n = 11,447) 1924 (16.8) & (n = 12,317) 2060 (16.7) & 0.37 \\ \hline Active cancer, n (\%) & (n = 844) 102 (12.1) & (n = 11,101) 1787 (16.1) & (n = 11,945) 1889 (15.8) & 0.002 \\ \hline Congestive heart failure, n (\%) & (n = 879) 97 (11.0) & (n = 11,460) 1630 (14.2) & (n = 12,339) 1727 (14.0) & 0.009 \\ \hline Chronic renal insufficiency, n (\%) & (n = 872) 54 (6.2) & (n = 11,481) 1285 (11.2) & (n = 12,353) 1339 (10.8) & <0.001 \\ \hline Chronic liver disease, n (\%) & (n = 843) 48 (5.7) & (n = 11,142) 727 (6.5) & (n = 11,985) 775 (6.5) & 0.34 \\ \hline Other, n (\%) & (n = 768) 197 (25.7) & (n = 10,369) 2473 (23.9) & (n = 11,125) 2670 (24.0) & 0.90 \\ \hline \end{tabular} \end{table}
PMC2717475_table_4
\begin{table} \centering \label{tab:tablelabel} \begin{tabular}{|l|l|l|l|l|} \hline & & & \multicolumn{2}{c|}{\textbf{DrotAA-treated patients}} \\ \hline \textbf{Country} & \textbf{Number of sites} & \textbf{Enrolled patients, n (\% overall) (n = 12,492)} & \textbf{n, (\% of total DrotAA patients) [Overall rank] (n = 882)} & \textbf{Within-country DrotAA use, \% (DrotAA patients/Total patients) [Rank]} \\ \hline Germany* & 17 & 1810 (14.5) & 98 (11.1) [3] & 5.4 (98/1810) [11] \\ \hline Argentina* & 18 & 1269 (10.1) & 22 (2.5) [9] & 1.7 (22/1269) [15] \\ \hline Canada*† & 12 & 1213 (9.7) & 101 (11.5) [2] & 8.3 (101/1213) [7] \\ \hline Brazil*† & 9 & 968 (7.7) & 65 (7.4) [4] & 6.7 (65/968) [9] \\ \hline India* & 21 & 803 (6.4) & 29 (3.3) [8] & 3.6 (29/803) [12] \\ \hline United States*† & 26 & 760 (6.1) & 206 (23.3) [1] & 27.1 (206/760) [2] \\ \hline Australia*† & 4 & 667 (5.3) & 53 (6.0) [6] & 7.9 (53/667) [8] \\ \hline Malaysia* & 4 & 641 (5.1) & 12 (1.4) [11] & 1.9 (12/641) [14] \\ \hline Philippines* & 10 & 489 (3.9) & 10 (1.1) [12] & 2.0 (10/489) [13] \\ \hline Mexico*† & 10 & 475 (3.8) & 54 (6.1) [5] & 11.4 (54/475) [6] \\ \hline Belgium† & 7 & 360 (2.9) & 43 (4.9) [7] & 11.9 (43/360) [5] \\ \hline Poland† & 10 & 210 (1.7) & 29 (3.3) [8] & 13.8 (29/210) [4] \\ \hline New Zealand† & 1 & 145 (1.2) & 9 (1.0) [13] & 6.2 (9/145) [10] \\ \hline Turkey† & 16 & 128 (1.2) & 43 (4.9) [7] & 33.6 (43/128) [1] \\ \hline Algeria† & 6 & 105 (0.8) & 19 (2.2) [10] & 18.1 (19/105) [3] \\ \hline \end{tabular} \end{table}
PMC2717475_table_5
\begi\textbf{n}{table} \ce\textbf{n}teri\textbf{n}g \label{tab:tablelabel} \begi\textbf{n}{tabular}{|l|l|l|l|l|l|l|l|} \hli\textbf{n}e \textbf{Mode l} & \textbf{Hospital Mortality Adjusted by Treatme\textbf{n}t a\textbf{n}d} & \textbf{n} & \textbf{Adjusted R2 Value} & Good\textbf{n}ess of Fit Chi-square & P value for Treatme\textbf{n}t Factor i\textbf{n} Multivariate Model & Odds Ratio, Poi\textbf{n}t Estimate (95\% CI*) & Relative Risk Reductio\textbf{n} \\ \hli\textbf{n}e 1 & Prope\textbf{n}sity Quartiles† & 880 6 & 0.034 & 0.002 & 0.0005 & 0.745 (0.631, 0.879) & 15\% \\ \hli\textbf{n}e 2 & Age, Prope\textbf{n}sity Quartiles & 880 6 & 0.083 & 0.548 & 0.001 & 0.755 (0.638, 0.893) & 14\% \\ \hli\textbf{n}e 3 & Age, 7 OD1 & 893 9 & 0.159 & 0.073 & 0.0056 & 0.788 (0.665, 0.933) & 13\% \\ \hli\textbf{n}e 4 & 7 OD, Prope\textbf{n}sity Quartiles & 880 6 & 0.133 & 0.14 & 0.0002 & 0.722 (0.609, 0.857) & 17\% \\ \hli\textbf{n}e 5 & Age, 7 OD, Prope\textbf{n}sity Quartiles & 880 6 & 0.161 & 0.258 & 0.0005 & 0.735 (0.618, 0.874) & 16\% \\ \hli\textbf{n}e 6 & Age, 7 OD, Vasopressors, Prope\textbf{n}sity Quartiles & 880 6 & 0.190 & 0.178 & 0.0006 & 0.739 (0.622, 0.878) & 16\% \\ \hli\textbf{n}e 7 & Age, 7 OD, Site of I\textbf{n}fectio\textbf{n}, Prope\textbf{n}sity Quartiles & 880 6 & 0.173 & 0.68 & 0.0009 & 0.744 (0.625, 0.866) & 15\% \\ \hli\textbf{n}e 8 & Age, 7 OD, Active Ca\textbf{n}cer Descriptio\textbf{n}, Prope\textbf{n}sity Quartiles & 880 6 & 0.170 & 0.821 & 0.0012 & 0.751 (0.631, 0.893) & 15\% \\ \hli\textbf{n}e 9 & Age, 7 OD, Active Ca\textbf{n}cer, Prope\textbf{n}sity Quartiles & 840 8 & 0.167 & 0.952 & 0.0003 & 0.72 (0.603, 0.860) & 17\% \\ \hli\textbf{n}e 10 & Age, 7 OD, Active Ca\textbf{n}cer, Source of I\textbf{n}fectio\textbf{n}, Prope\textbf{n}sity Quartiles & 814 2 & 0.172 & 0.852 & 0.0002 & 0.712 (0.594, 0.854) & 18\% \\ \hli\textbf{n}e 11 & Age, 7 OD, Active Ca\textbf{n}cer, Source of I\textbf{n}fectio\textbf{n}, Vasopressors, Prope\textbf{n}sity Quartile & 814 2 & 0.200 & 0.131 & 0.0003 & 0.717 (0.598, 0.860) & 18\% \\ \hli\textbf{n}e 12 & Age, 7 OD, Active Ca\textbf{n}cer, Vasopressors, Prope\textbf{n}sity Quartile & 840 8 & 0.197 & 0.278 & 0.0004 & 0.726 (0.607, 0.867) & 18\% \\ \hli\textbf{n}e 13 & APACHE2 II Score, Prope\textbf{n}sity Quartiles & 643 1 & 0.162 & 0.658 & 0.0007 & 0.692 (0.559, 0.856) & 18\% \\ \hli\textbf{n}e 14 & Imputed APACHE II Score, Prope\textbf{n}sity Quartiles & 880 6 & 0.128 & 0.956 & <0.0001 & 0.71 (0.599, 0.843) & 17\% \\ \hli\textbf{n}e 15 & Age, 7 OD, Imputed APACHE II Score, Prope\textbf{n}sity Quartiles & 880 6 & 0.198 & 0.765 & 0.0002 & 0.714 (0.599, 0.851) & 18\% \\ \hli\textbf{n}e 16 & Age, 7 OD, Regio\textbf{n}3, Prope\textbf{n}sity Quartiles & 880 6 & 0.170 & 0.559 & 0.004 & 0.77 (0.644, 0.92) & 14\% \\ \hli\textbf{n}e 17 & Age, 4 OD (\textbf{n}o Cardiologic, Metabolic, Re\textbf{n}al), Mecha\textbf{n}ical Ve\textbf{n}tilatio\textbf{n}, Re\textbf{n}al Replaceme\textbf{n}t Therapy, Platelet Tra\textbf{n}sfusio\textbf{n}, E\textbf{n}teral Nutritio\textbf{n}, Mecha\textbf{n}ical-VTE- Prophylaxis, LMWH, Active Ca\textbf{n}cer, Prope\textbf{n}sity Quartiles & 828 3 & 0.278 & 0.028 & 0.0115 & 0.783 (0.647, 0.947) & 13\% \\ \hli\textbf{n}e \e\textbf{n}d{tabular} \e\textbf{n}d{table}
PMC2717475_table_6
\begin{table} \centering \label{tab:tablelabel} \begin{tabular}{|l|l|l|l|l|} \hline \textbf{Variable} & \textbf{DrotAA n = 882} & \textbf{Non-DrotAA n = 11,610} & \textbf{Total n = 12,492} & \textbf{value P} \\ \hline Discharge location by DrotAA use, n (\%): & (n = 807) & (n = 10,537) & (n = 11,344) & <0.001 \\ \hline Died & 400 (49.6) & 5236 (49.7) & 5636 (49.7) \\ \hline Community & 236 (29.2) & 3652 (34.7) & 3888 (34.3) \\ \hline Other hospital & 73 (9.0) & 856 (8.1) & 929 (8.2) \\ \hline Extended/Chronic care Institution & 83 (10.3) & 620 (5.9) & 703 (6.2) \\ \hline Other/Unknown & 15 (1.9) & 173 (1.6) & 188 (1.7) \\ \hline Hospital mortality for DrotAA therapy, adjusted for Age, 7 OD*, Active Cancer, and Propensity Quartiles† & Adjusted Odds Ratio & 95\% Confidence Interval & ---- & P value \\ \hline All patients** & 0.72 & 0.603 – 0.86 & ---- & 0.0003 \\ \hline \end{tabular} \end{table}
PMC2717475_table_7
\begin{table} \centering \label{tab:tablelabel} \begin{tabular}{|l|l|l|} \hline \textbf{Virus} & \textbf{Serotypes} \\ \hline Rhinovirus & > 101 \\ \hline Influenza & A, B \\ \hline RSV & A, B & Panel A63B \\ \hline Metapneumovirus & A, B \\ \hline Parainfluenza virus & I, II, III \\ \hline Adenovirus & > 13 serotypes of groups B, C, E \\ \hline Coronavirus & OC43, 229E, NL63, SARS \\ \hline Enterovirus & > 34 & Panel C3B \\ \hline \end{tabular} \end{table}
PMC2717562_table_0
\begin{table} \centering \label{tab:tablelabel} \begin{tabular}{|l|l|l|l|l|l|} \hline & \multicolumn{2}{c|}{\textbf{Acute (n = 70)}} & \multicolumn{2}{c|}{\textbf{Stable (n = 80)}} & \textbf{Value P} \\ \hline & \textbf{\textbf{No.}} & \textbf{\textbf{\%}} & \textbf{\textbf{No.}} & \textbf{\textbf{\%}} \\ \hline Gender \\ \hline Male & 52 & 74.3 & 62 & 77.5 & 0.646 \\ \hline Female & 18 & 25.7 & 18 & 22.5 \\ \hline Age (years) \\ \hline Mean (SD) & 8.0 & (3.5) & 8.8 & (3.2) & 0.171 \\ \hline Ethnicity \\ \hline African & 29 & 41.4 & 29 & 36.3 & 0.018 \\ \hline Asian Indian & 20 & 28.6 & 11 & 13.8 \\ \hline Mixed (African & Asian Indian) & 21 & 30.0 & 40 & 50.0 \\ \hline Season specimen was collected \\ \hline Dry & 21 & 30.0 & 17 & 21.3 & 0.219 \\ \hline Rainy & 49 & 70.0 & 63 & 78.8 \\ \hline \end{tabular} \end{table}
PMC2717562_table_1
\begin{table} \centering \label{tab:tablelabel} \begin{tabular}{|l|l|l|l|l|} \hline \textbf{Virus} & \multicolumn{2}{c|}{\textbf{Acute (N = 70)}} & \multicolumn{2}{c|}{\textbf{Stable (N = 80)}} \\ \hline & \textbf{\textbf{No.}} & \textbf{\textbf{\%}} & \textbf{\textbf{No.}} & \textbf{\textbf{\%}} \\ \hline Total virus (p = 0.018) & 24 & 34.3 & 14 & 17.5 \\ \hline \textbf{Virus} not present & 46 & 65.7 & 66 & 82.5 \\ \hline RV (p = 0.005) & 18 & 25.7 & 7 & 8.8 \\ \hline RV/Total virus & 0.75 & 75.0 & 0.50 & 50.0 \\ \hline RSVA & 0 & 0.0 & 0 & 0.0 \\ \hline RSV B & 2 & 2.9 & 4 & 5.0 \\ \hline Influenza A & 2 & 2.9 & 0 & 0.0 \\ \hline Influenza B & 0 & 0.0 & 0 & 0.0 \\ \hline Coronavirus OC43 & 1 & 1.4 & 0 & 0.0 \\ \hline Coronavirus NL63 & 0 & 0.0 & 1 & 1.3 \\ \hline Coronavirus 229E & 0 & 0.0 & 0 & 0.0 \\ \hline Coronavirus SARS & 0 & 0.0 & 0 & 0.0 \\ \hline EV & 1 & 1.4 & 2 & 2.5 \\ \hline PIV 1 & 1 & 1.4 & 0 & 0.0 \\ \hline PIV 2 & 1 & 1.4 & 0 & 0.0 \\ \hline PIV 3 & 0 & 0.0 & 0 & 0.0 \\ \hline hMPV & 0 & 0.0 & 1 & 1.3 \\ \hline Adenovirus & 0 & 0.0 & 0 & 0.0 \\ \hline Co-infection with 2 viruses & 2 & 2.9 & 1 & 1.3 \\ \hline -Influenza A & RSV B & 1 & 1.4 & 0 & 0.0 \\ \hline - Influenza A &RV & 1 & 1.4 & 0 & 0.0 \\ \hline - RV & RSV B & 0 & 0.0 & 1 & 1.3 \\ \hline \end{tabular} \end{table}
PMC2717562_table_2
\begin{table} \centering \label{tab:tablelabel} \begin{tabular}{|l|l|} \hline \textbf{Patient's Characteristics} \\ \hline Male/Female ratio & 1:1 \\ \hline Age (y), median (range) & 4.5 (6.0 mo-10 y) \\ \hline Total serum IgE at baseline (IU/mL) & 335,93 \\ \hline Positive Skin Prick Tests to: (n) \\ \hline Cow's milk & 27 \\ \hline Ass's milk & 2 \\ \hline Wheat & 2 \\ \hline Hen's egg & 7 \\ \hline Soy & 4 \\ \hline Pollens & 5 \\ \hline Dust mite & 7 \\ \hline Molds & 2 \\ \hline Pets with fur & 4 \\ \hline Positive specific IgE to: (n) \\ \hline alpha-lactalbumin & 21 \\ \hline beta-lactoglobulin & 17 \\ \hline casein & 9 \\ \hline Ass's milk & 2 \\ \hline \end{tabular} \end{table}
PMC2717565_table_0
\begin{table} \centering \label{tab:tablelabel} \begin{tabular}{|l|l|l|} \hline \textbf{W (Kg) mean $\pm$ SD} & \textbf{H (cm) mean $\pm$ SD} & \textbf{BMI mean $\pm$ SD (centiles)} \\ \hline All children \\ \hline T0 17,3 $\pm$ 9,6 & T0 100,3 $\pm$ 14,9 & T0 16,1 $\pm$ 1,5 (50°) \\ \hline T1 19,4 $\pm$ 11,6 & T1 105,4 $\pm$ 23,2 & T1 16,0 $\pm$ 2,1 (50°) \\ \hline p = 0.02 & p < 0.001 & p = ns \\ \hline Boys \\ \hline T0 16,9 $\pm$ 6,7 & T0 102,2 $\pm$ 23,7 & T0 15,8 $\pm$ 1,1 (50°) \\ \hline T1 18,3 $\pm$ 7,2 & T1 106,3 $\pm$ 20,8 & T1 15,6 $\pm$ 0,8 (50°) \\ \hline p < 0.01 & p = 0.03 & p = ns \\ \hline Girls \\ \hline T0 17,9 $\pm$ 13,3 & T0 98,1 $\pm$ 29,0 & T0 16,5 $\pm$ 2,0 (50°) \\ \hline T1 20,6 $\pm$ 16,4 & T1 104,2 $\pm$ 28,2 & T1 16,6 $\pm$ 3,0 (50°) \\ \hline p = ns & p < 0.01 & p = ns \\ \hline \end{tabular} \end{table}
PMC2717565_table_1
\begin{table} \centering \label{tab:tablelabel} \begin{tabular}{|l|l|l|} \hline \textbf{Entry vector type} & \textbf{Compatible Destination vectors} & \textbf{Incompatible Destination vectors} \\ \hline \multirow{4}{*}{pENTR/pSM2 Series (non-GFP)} & pLenti X1 Series & Seriesb pLenti PGK \\ \hline pLenti X2 Series & Seriesb pLenti CMV \\ \hline pLenti CMV GFP & Seriesb pLenti CMV/TO \\ \hline Seriesa pQCXI RNAi X2 & Seriesb pQCXI CMV/TO \\ \hline \multirow{4}{*}{pENTR/pSM2(CMV-GFP)} & pLenti X1 Series & Seriesc pLenti X2 \\ \hline & GFPd pLenti CMV \\ \hline & Seriesb pQCXI CMV/TO \\ \hline & Seriesc pQCXI RNAi X2 \\ \hline \multirow{4}{*}{pENTR/pTER+ pENTR/pSUPER+} & pLenti X1 Series & Seriesb pLenti PGK \\ \hline pLenti X2 Series & Seriesb pLenti CMV \\ \hline pLenti CMV GFP & Seriesb pLenti CMV/TO \\ \hline pQCXI RNAi X2 Series & Seriesb pQCXI CMV/TO \\ \hline \multirow{6}{*}{pEF-ENTR Series} & pLenti X1 Series & Seriesc pLenti X2 \\ \hline pLenti CMV GFP & Seriesb pLenti PGK \\ \hline & Seriesb pLenti CMV \\ \hline & Seriesb pLenti CMV/TO \\ \hline & Seriesb pQCXI CMV/TO \\ \hline & Seriesc pQCXI RNAi X2 \\ \hline \multirow{4}{*}{pENTR-Fusion Series} & pLenti PGK Series & Seriese pLenti X1 \\ \hline pLenti CMV Series & Seriesc,e pLenti X2 \\ \hline pLenti CMV/TO Series & GFPe pLenti CMV \\ \hline pQCXI CMV/TO Series & pQCXI RNAi X2 Seriesc,e \\ \hline \end{tabular} \end{table}
PMC2717805_table_0
\begin{table} \centering \label{tab:tablelabel} \begin{tabular}{|l|l|} \hline \textbf{Vector} & \textbf{Inducible expression in a T-REx cell line} \\ \hline pENTR/pSUPER+ & NO \\ \hline + pENTR/pTER & YES \\ \hline pENTR/pSM2(U6) & NO \\ \hline pENTR/pSM2 (CMV) & NO \\ \hline pENTR/pSM2 (CMV/TO) & YES \\ \hline pLenti CMV Series & NO \\ \hline pLenti CMV/TO Series & YES \\ \hline pLenti PGK Series & NO \\ \hline pQCXI CMV/TO Series & YES* \\ \hline pQCXP & YES \\ \hline \end{tabular} \end{table}
PMC2717805_table_1
\begin{table} \centering \label{tab:tablelabel} \begin{tabular}{|l|l|l|l|l|} \hline \textbf{Vector Series} & \textbf{pSUPER, pTER} & \textbf{pSM2-CMV, CMV/TO} & \textbf{pSM2 CMV-GFP} & \textbf{pEF-Series} \\ \hline Lenti X2 Blast & 104 & & N/A & N/A \\ \hline Lenti X2 Hygro & 105 & 104 & N/A & N/A \\ \hline Lenti X2 Neo & 105 & 105 & N/A & N/A \\ \hline Lenti X2 Puro & 105 & & N/A & N/A \\ \hline Lenti X2 Zeo & 105 & & N/A & N/A \\ \hline Lenti X1 Puro & 105 & 105 & 104 \\ \hline Lenti X1 Zeo & 105 \\ \hline Lenti X1 GFP-Zeo & 105 & & N/A \\ \hline QCXIN X2 & 105 & 103 & N/A & N/A \\ \hline QCXIP X2 & 105 & & N/A & N/A \\ \hline \end{tabular} \end{table}
PMC2717805_table_2
\begin{table} \centering \label{tab:tablelabel} \begin{tabular}{|l|l|l|l|l|l|} \hline \textbf{Tag sequence} & \textbf{Number of tags in disease libraries*} & \textbf{Number of tags in normal libraries} & \textbf{Gene} & \textbf{Fold increase from normal} & \textbf{RefSeq accession number} \\ \hline & & CINIII \\ \hline GACCCAAGATAAAAGAA & 704 & 16 & PIGR & 22.4 & NM_002644 \\ \hline ATCCCCCTGGGCATCGG & 52 & 2 & SLC39A3 & 13.2 & NM_144564 \\ \hline ACTCAGACCAGGTCCCA & 94 & 4 & STRA6 & 11.4 & NM_022369 \\ \hline ACACAGTATTCGCTCTT & 44 & 2 & ITR & 11.2 & NM_180989 \\ \hline TTACTTCCCCACCCCTA & 84 & 4 & FADS2 & 10.7 & NM_004265 \\ \hline GGAACTGTGAAGAGGCA & 230 & 12 & TSPAN1 & 9.7 & NM_005727 \\ \hline GCACCTGTCGCCCAGTG & 36 & 2 & ANPEP & 9.2 & NM_001150 \\ \hline CCTGATCTGCGGTGTCC & 308 & 18 & MUC16 & 8.7 & NM_024690 \\ \hline CGTTTTCTGATAACTCA & 68 & 4 & PTP4A2 & 8.6 & XM_001132367 \\ \hline CAAATAAATTATGCGAT & 98 & 6 & TMPRSS2 & 8.3 & NM_005656 \\ \hline TGCTCCTACCCTGCTCT & 2022 & 190 & FCGBP & 5.4 & XM_001131379 \\ \hline GCAGTGCCACTCAAGAA & 726 & 68 & SRD5A2L & 5.4 & NM_024592 \\ \hline CCTGGGAAGTGTTGTGG & 730 & 98 & MUC1 & 3.8 & NM_001044391 \\ \hline AATATTTATATTGTATG & 1880 & 400 & CEACAM5 & 2.4 & NM_004363 \\ \hline GTTCACATTAGAATAAA & 3424 & 762 & CD74 & 2.3 & NM_001025158 \\ \hline GGGCATCTCTTGTGTAC & 1602 & 350 & HLA-DRA & 2.3 & NM_019111 \\ \hline TGCTGCCTGTTGTTATG & 826 & 192 & BST2 & 2.2 & NM_004335 \\ \hline CTGACCTGTGTTTCCTC & 596 & 144 & HLA-B & 2.1 & NM_005514 \\ \hline GCAGGGCCTCATCTCAC & 1950 & 484 & FXYD3 & 2.0 & NM_005971 \\ \hline & & CINI \\ \hline GCACCTGTCGCCCAGTG & 42 & 2 & ANPEP & 36.5 & NM_001150 \\ \hline ATGTTAATAAAATAGGC & 66 & 4 & GPC4 & 28.7 & NM_001448 \\ \hline ATAAATGATTAGACTAC & 32 & 2 & CLIC6 & 27.8 & NM_053277 \\ \hline GGCCAAGAACTTTCACT & 28 & 2 & C14orf101 & 24.3 & NM_017799 \\ \hline GACCCAAGATAAAAGAA & 262 & 16 & PIGR & 23.0 & NM_002644 \\ \hline TAGGTCAGGACCTTGGC & 26 & 2 & PTP4A3 & 22.6 & NM_032611 \\ \hline GTATATAACTCTTAAAG & 24 & 2 & LOC644410** & 20.8 & XM_001133198 \\ \hline CCAGCTGCCTGGAGGAG & 22 & 2 & MGC45438 & 19.1 & NM_152459 \\ \hline ATAAAAATTAGGGGGAT & 22 & 2 & SLC30A1 & 19.1 & NM_021194 \\ \hline TGAGCTACCCCAGAGTC & 20 & 2 & FER1L4 & 17.4 & NR_001442 \\ \hline TACATCAGTAAAGAGTT & 374 & 42 & GAS1 & 12.5 & NM_002048 \\ \hline CATCACGGATCAATAGA & 330 & 64 & IL1R1 & 7.2 & NM_000877 \\ \hline CCTGGGAAGTGTTGTGG & 334 & 98 & MUC1 & 4.1 & NM_001044391 \\ \hline TGCAGATTGCAGTTCTG & 366 & 132 & PROM1 & 3.9 & NM_006017 \\ \hline CACTTCAAGGGCAGCCT & 238 & 102 & LY6E & 3.3 & NM_002346 \\ \hline GTTCACATTAGAATAAA & 1660 & 762 & CD74 & 3.1 & NM_001025158 \\ \hline GGGCATCTCTTGTGTAC & 734 & 350 & HLA-DRA & 3.0 & NM_019111 \\ \hline TGCTCCTACCCTGCTCT & 402 & 190 & FCGBP & 3.0 & XM_001131379 \\ \hline CTGACCTGTGTTTCCTC & 256 & 144 & HLA-B & 2.5 & NM_005514 \\ \hline \end{tabular} \end{table}
PMC2717845_table_0
\begin{table} \centering \label{tab:tablelabel} \begin{tabular}{|l|l|l|l|l|l|} \hline \textbf{Trait} & \textbf{Marker*} & \textbf{Beta**} & \textbf{t-value} & \textbf{R2 Adjusted} & \textbf{Signifi cance (P)} \\ \hline \multirow{5}{*}{TLD} & 825.9 & –0.874 & 5.404 & 0.738 & 0.000 \\ \hline +835.11 & 0.361 & 3.032 & 0.863 & 0.016 \\ \hline +825.2 & 0.270 & 3.725 & 0.947 & 0.007 \\ \hline +811.3 & –0.165 & 3.041 & 0.976 & 0.023 \\ \hline +807.4 & –0.124 & 4.658 & 0.995 & 0.006 \\ \hline \multirow{5}{*}{LWT} & 830.8 & –0.933 & 8.957 & 0.859 & 0.000 \\ \hline +851.1 & –0.374 & 3.649 & 0.930 & 0.004 \\ \hline +836.4 & 0.196 & 3.834 & 0.969 & 0.003 \\ \hline +886.13 & –0.127 & 3.528 & 0.986 & 0.006 \\ \hline +886.6 & –0.097 & 3.943 & 0.994 & 0.004 \\ \hline \multirow{5}{*}{CWT} & 830.8 & –0.943 & 8.529 & 0.878 & 0.000 \\ \hline +810.2 & 0.268 & 3.640 & 0.948 & 0.007 \\ \hline +844.5 & –0.206 & 4.332 & 0.984 & 0.003 \\ \hline +830.7 & –0.191 & 3.996 & 0.995 & 0.007 \\ \hline +864.7 & 0.074 & 6.087 & 0.999 & 0.002 \\ \hline \multirow{5}{*}{SWT} & 830.8 & –0.909 & 6.559 & 0.808 & 0.000 \\ \hline +834.11 & 0.359 & 3.870 & 0.925 & 0.005 \\ \hline +886.5 & 0.263 & 4.040 & 0.974 & 0.005 \\ \hline +885.13 & –0.146 & 3.947 & 0.992 & 0.008 \\ \hline +818.1 & 0.081 & 3.199 & 0.997 & 0.024 \\ \hline \multirow{6}{*}{SR} & 830.8 & –0.823 & 4.344 & 0.641 & 0.002 \\ \hline +834.11 & 0.459 & 3.255 & 0.826 & 0.012 \\ \hline +884.9 & –0.313 & 3.482 & 0.927 & 0.010 \\ \hline +826.5 & –0.200 & 3.014 & 0.966 & 0.024 \\ \hline +811.4 & –0.141 & 4.842 & 0.993 & 0.005 \\ \hline +827.2 & 0.063 & 4.456 & 0.999 & 0.011 \\ \hline \multirow{7}{*}{Floss} & 830.8 & 0.812 & 4.818 & 0.631 & 0.000 \\ \hline +835.5 & 0.449 & 2.893 & 0.771 & 0.015 \\ \hline +884.1 & –0.471 & 3.861 & 0.899 & 0.003 \\ \hline +811.3 & –0.276 & 4.515 & 0.966 & 0.001 \\ \hline +830.11 & –0.150 & 4.545 & 0.989 & 0.002 \\ \hline +851.3 & –0.074 & 3.772 & 0.996 & 0.007 \\ \hline +886.4 & 0.049 & 4.282 & 0.999 & 0.005 \\ \hline \multirow{6}{*}{Silk waste} & 881.4 & –0.769 & 4.168 & 0.557 & 0.001 \\ \hline +885.7 & 0.443 & 3.108 & 0.743 & 0.010 \\ \hline +825.6 & –0.403 & 5.359 & 0.927 & 0.000 \\ \hline +836.15 & –0.245 & 5.033 & 0.979 & 0.001 \\ \hline +886.6 & 0.147 & 4.578 & 0.993 & 0.002 \\ \hline +826.3 & 0.068 & 4.185 & 0.998 & 0.004 \\ \hline \end{tabular} \end{table}
PMC2717847_table_0
\begin{table} \centering \label{tab:tablelabel} \begin{tabular}{|l|l|l|l|} \hline & \multirow{2}{*}{\textbf{Total (N = 119)}} & \multirow{2}{*}{\textbf{With Data* (N = 78) N (\%)}} & \multirow{2}{*}{\textbf{Without Data* (N = 41) N (\%)}} \\ \hline \\ \hline Sex \\ \hline Male & 64 (53.8) & 44 (56.4) & 20 (48.8) \\ \hline Female & 55 (46.2) & 34 (43.6) & 21 (51.2) \\ \hline Race/ethnicity \\ \hline Hispanic & 25 (21.0) & 16 (20.5) & 9 (22.0) \\ \hline Black & 62 (52.1) & 43 (55.1) & 19 (46.3) \\ \hline White/Asian/Other & 4 (3.4) & 2 (2.6) & 2 (4.9) \\ \hline More than one race & 24 (20.1) & 14 (17.9) & 10 (24.4) \\ \hline Unknown & 4 (3.4) & 3 (3.9) & 1(2.4) \\ \hline NICU admissions & 8 (6.7) & 4 (5.3) & 4 (9.8) \\ \hline Maternal History** \\ \hline Eczema & 37 (33.0) & 23 (31.9) & 14 (35.0) \\ \hline Asthma & 59 (53.2) & 40 (55.6) & 19 (48.7) \\ \hline Hay fever & 51 (46.4) & 34 (48.6) & 17 (42.5) \\ \hline Paternal History** \\ \hline Eczema & 22 (17.5) & 13 (21.0) & 3 (8.3) \\ \hline Asthma & 35 (27.8) & 20 (32.3) & 9 (25.0) \\ \hline Hay fever & 30 (25.9) & 15 (27.8) & 12 (34.3) \\ \hline \end{tabular} \end{table}
PMC2717905_table_0
\begin{table} \centering \label{tab:tablelabel} \begin{tabular}{|l|l|l|l|} \hline & \multirow{2}{*}{\textbf{Total (n = 82)}} & \multirow{2}{*}{\textbf{With Data (N = 52) N (\%)}} & \multirow{2}{*}{\textbf{Without Data (N = 30) N (\%)}} \\ \hline \\ \hline Race/ethnicity \\ \hline Hispanic & 24 (29.6) & 16 (31.4) & 8 (26.7) \\ \hline Black & 40 (49.4) & 20 (39.2) & 20 (66.7) \\ \hline White/Asian/Other & 7 (8.6) & 6 (11.8) & 1 (3.3) \\ \hline More than one race & 10 (12.4) & 9 (17.7) & 1 (3.3) \\ \hline Atopic disease \\ \hline Eczema & 30 (37.0) & 19 (37.3) & 11 (36.7) \\ \hline Asthma* & 48 (60.0) & 26 (51.0) & 22 (75.9) \\ \hline Hay fever & 39 (49.4) & 27 (55.1) & 12 (40.0) \\ \hline \multirow{2}{*}{Intake of steroids during pregnancy} & 18 (22.0) & 11 (21.2) & 7 (23.3) \\ \hline & Mean (SD) \\ \hline Age & 26.1 (6.7) & 26.9 (7.2) & 24.7 (5.7) \\ \hline \end{tabular} \end{table}
PMC2717905_table_1
\begin{table} \centering \label{tab:tablelabel} \begin{tabular}{|l|l|l|l|l|l|l|l|} \hline & \multicolumn{3}{c|}{\textbf{Cord Blood}} & \multicolumn{3}{c|}{\textbf{Maternal Peripheral Blood}} \\ \hline & \textbf{\textbf{N}} & \textbf{\textbf{Median \%}} & \textbf{\textbf{Range}} & \textbf{\textbf{N}} & \textbf{\textbf{Median \%}} & \textbf{\textbf{Range}} & \textbf{Wilcoxon p-value} \\ \hline CD4+CD25+ & 114 & 6.9 & 0.9–17.7 & 79 & 13.3 & 3.3–38.1 & <0.0001 \\ \hline CD4+CD25+bright & 114 & 1.4 & 0.2–8.5 & 79 & 1.9 & 0.6–4.5 & 0.002 \\ \hline CD4+CD25+FOXP3 & 63 & 3.3 & 0.1–7.8 & 78 & 3.1 & 0.5–6.7 & 0.71 \\ \hline \end{tabular} \end{table}
PMC2717905_table_2
\begin{table} \centering \label{tab:tablelabel} \begin{tabular}{|l|l|l|l|l|l|l|} \hline & & \multicolumn{4}{c|}{\textbf{Proliferation Index (PI)*}} \\ \hline & & \multicolumn{2}{c|}{\textbf{CD25+ Undepleted}} & \multicolumn{2}{c|}{\textbf{CD25+ Depleted}} \\ \hline & \textbf{N} & \textbf{\textbf{Median}} & \textbf{\textbf{Range}} & \textbf{\textbf{Median}} & \textbf{\textbf{Range}} & \textbf{Wilcoxon p-value} \\ \hline Cord blood & 78 & 101.8 & 5.7–776.7 & 109.9 & 5.4–943.6 & 0.56 \\ \hline Maternal Peripheral blood & 52 & 216.7 & 1.0–713.8 & 238.3 & 0.7–798.0 & 0.02 \\ \hline \end{tabular} \end{table}
PMC2717905_table_3
\begin{table} \centering \label{tab:tablelabel} \begin{tabular}{|l|l|l|l|} \hline & \textbf{lactate+1B} & \textbf{lactate+2B} & \textbf{lactate+3B} \\ \hline #6 & 0.80\% & 0.36\% & 1.89\% \\ \hline #7 & 0.00\% & 1.83\% & 4.84\% \\ \hline #8 & 2.94\% & 0.16\% & 3.31\% \\ \hline #9 & 0.00\% & 4.11\% & 3.47\% \\ \hline #10 & 2.01\% & 1.00\% & 6.37\% \\ \hline \end{tabular} \end{table}
PMC2717907_table_0
\begin{table} \centering \label{tab:tablelabel} \begin{tabular}{|l|l|l|l|l|l|l|l|l|} \hline \textbf{Compound} & \multicolumn{2}{c|}{\textbf{\% [U-13C]-AlaA}} & \multicolumn{2}{c|}{\textbf{\% [U-13C]-LactateA}} & \multicolumn{2}{c|}{\textbf{\% [U-13C]-GlucoseA}} & \multicolumn{2}{c|}{\textbf{\% [13C-2]-GluA}} \\ \hline & \textbf{\textbf{\textbf{\textbf{Non-cancerous}}}} & \textbf{\textbf{\textbf{\textbf{Cancer}}}} & \textbf{\textbf{\textbf{\textbf{Non-cancerous}}}} & \textbf{\textbf{\textbf{\textbf{Cancer}}}} & \textbf{\textbf{\textbf{\textbf{Non-cancerous}}}} & \textbf{\textbf{\textbf{\textbf{Cancer}}}} & \textbf{\textbf{\textbf{\textbf{Non-cancerous}}}} & \textbf{\textbf{\textbf{\textbf{Cancer}}}} \\ \hline \textbf{Mean} & \textbf{1.8} & \textbf{9.1} & \textbf{8.6} & \textbf{15.1} & \textbf{15.5} & \textbf{NDB} & \textbf{5.4} & \textbf{8.3} \\ \hline SDC & 0.9 & 4.9 & 4.6 & \textbf{5.4} & 2.3 & - & 1.1 & 1.9 \\ \hline p valueD & \multicolumn{2}{c|}{0.009} & \multicolumn{2}{c|}{0.02} & \multicolumn{2}{c|}{-} & \multicolumn{2}{c|}{0.012} \\ \hline \end{tabular} \end{table}
PMC2717907_table_1
\begin{table} \centering \label{tab:tablelabel} \begin{tabular}{|l|l|l|l|l|l|l|l|l|l|l|} \hline \textbf{\textbf{\textbf{\textbf{\textbf{C}}}}ompound} & \multicolumn{2}{c|}{\textbf{#6 sq\textbf{\textbf{\textbf{\textbf{\textbf{C}}}}B}, grade II}} & \multicolumn{2}{c|}{\textbf{#7 adeno\textbf{\textbf{\textbf{\textbf{\textbf{C}}}}B}, grade II}} & \multicolumn{2}{c|}{\textbf{#8 sq\textbf{\textbf{\textbf{\textbf{\textbf{C}}}}B}, grade II-III}} & \multicolumn{2}{c|}{\textbf{#9 sq\textbf{\textbf{\textbf{\textbf{\textbf{C}}}}B}, grade II}} & \multicolumn{2}{c|}{\textbf{#10 sq\textbf{\textbf{\textbf{\textbf{\textbf{C}}}}B}, grade III}} \\ \hline & \textbf{\textbf{\textbf{\textbf{\textbf{N}}}}B} & \textbf{\textbf{\textbf{\textbf{\textbf{C}}}}B} & \textbf{\textbf{\textbf{\textbf{N}}}} & \textbf{\textbf{\textbf{\textbf{C}}}} & \textbf{\textbf{\textbf{\textbf{N}}}} & \textbf{\textbf{\textbf{\textbf{C}}}} & \textbf{\textbf{\textbf{\textbf{N}}}} & \textbf{\textbf{\textbf{\textbf{C}}}} & \textbf{\textbf{\textbf{\textbf{N}}}} & \textbf{\textbf{\textbf{\textbf{C}}}} \\ \hline Total Ala & 4.67 & 15.76 & 6.25 & 6.44 & 4.97 & 9.28 & 5.14 & 15.08 & 5.42 & 27.34 \\ \hline 13\textbf{\textbf{\textbf{\textbf{C}}}}-Ala\textbf{\textbf{\textbf{\textbf{C}}}} & 0.03 & 0.28 & 0.15 & 0.34 & 0.09 & 0.57 & 0.21 & 0.79 & 0.29 & 1.60 \\ \hline Total Asp & 1.32 & 4.27 & 3.83 & 3.09 & 2.67 & 1.51 & 1.94 & 4.78 & 2.27 & 1.66 \\ \hline 13\textbf{\textbf{\textbf{\textbf{C}}}}-Asp\textbf{\textbf{\textbf{\textbf{C}}}} & 0.18 & 0.59 & 0.36 & 0.44 & 0.35 & 0.24 & 0.21 & 0.82 & 0.36 & 0.31 \\ \hline 13\textbf{\textbf{\textbf{\textbf{C}}}}3-Asp\textbf{\textbf{\textbf{\textbf{C}}}}, D & < 0.004 (< 0.3\%) & 0.058 (1.4\%) & 0.009 (0.2\%) & 0.005 (0.16\%) & 0.006 (0.2\%) & 0.009 (0.6\%) & < 0.004 (< 0.2\%) & 0.024 (0.5\%) & 0.004 (0.17\%) & 0.020 (1.2\%) \\ \hline Total \textbf{\textbf{\textbf{\textbf{C}}}}itB & 0.60 & 1.32 & 1.21 & 1.18 & 1.28 & 1.56 & 0.77 & 1.53 & 0.74 & 1.37 \\ \hline 13\textbf{\textbf{\textbf{\textbf{C}}}}-\textbf{\textbf{\textbf{\textbf{C}}}}itB, \textbf{\textbf{\textbf{\textbf{C}}}} & 0.03 & 0.10 & 0.02 & 0.05 & 0.08 & 0.12 & 0.03 & 0.11 & < 0.004 & 0.12 \\ \hline Total Glu & 0.24 & 4.80 & 2.96 & 2.97 & 1.88 & 3.25 & 1.91 & 4.78 & 1.82 & 3.28 \\ \hline 13\textbf{\textbf{\textbf{\textbf{C}}}}-Glu\textbf{\textbf{\textbf{\textbf{C}}}} & 0.03 & 0.16 & < 0.004 & < 0.004 & < 0.004 & 0.22 & < 0.004 & 0.36 & 0.10 & 0.36 \\ \hline Total Gln & 0.56 & 7.68 & 1.41 & 1.02 & 0.64 & 1.32 & 0.74 & 2.71 & 0.79 & 2.99 \\ \hline 13\textbf{\textbf{\textbf{\textbf{C}}}}-Gln\textbf{\textbf{\textbf{\textbf{C}}}} & 0.07 & 0.34 & 0.07 & 0.00 & 0.04 & 0.00 & 0.00 & 0.21 & 0.00 & 0.04 \\ \hline Total LacB & 2.66 & 29.55 & 11.80 & 10.62 & 9.44 & 17.72 & 19.52 & 25.31 & 8.27 & 29.67 \\ \hline 13\textbf{\textbf{\textbf{\textbf{C}}}}-Lac\textbf{\textbf{\textbf{\textbf{C}}}} & < 0.004 & 0.66 & 0.19 & 0.63 & 0.19 & 0.88 & < 0.004 & 1.44 & 0.03 & 0.94 \\ \hline Total SuccB & 0.17 & 1.34 & 0.50 & 0.70 & 0.89 & 1.84 & 0.64 & 1.59 & 1.14 & 3.13 \\ \hline 13\textbf{\textbf{\textbf{\textbf{C}}}}-Succ\textbf{\textbf{\textbf{\textbf{C}}}} & 0.02 & 0.08 & 0.01 & 0.03 & 0.03 & 0.11 & 0.08 & 0.14 & 0.06 & 0.19 \\ \hline \end{tabular} \end{table}
PMC2717907_table_2
\begin{table} \centering \label{tab:tablelabel} \begin{tabular}{|l|l|l|} \hline & \multicolumn{2}{c|}{\textbf{R2}} \\ \hline \textbf{PlotsB} & \textbf{Non-cancerous} & \textbf{Cancer} \\ \hline [Ala] versus [succinate] & 0.025 & 0.761 \\ \hline [13C-Ala] versus [13C-succinate] & 0.483 & 0.792 \\ \hline [lactate] versus [succinate] & 0.056 & 0.395 \\ \hline [13C-lactate] versus [13C-succinate] & 0.412 & 0.374 \\ \hline [Glu] versus [succinate] & 0.018 & 0.343 \\ \hline [13C-Glu] versus [13C-succinate] & 0.072 & 0.912 \\ \hline [citrate] versus [succinate] & 0.061 & 0.133 \\ \hline [13C-citrate] versus [13C-succinate] & 0.069 & 0.789 \\ \hline \end{tabular} \end{table}
PMC2717907_table_3
\begin{table} \centering \label{tab:tablelabel} \begin{tabular}{|l|l|l|l|l|l|l|l|} \hline & \multicolumn{7}{c|}{\textbf{Fold ChangeA}} \\ \hline \textbf{GenesB} & \textbf{PC} & \textbf{GLS} & \textbf{IDH3} & \textbf{OGDH} & \textbf{SDH} & \textbf{FH} & \textbf{MDH2} \\ \hline AverageC & 3.36 & 0.52 & 0.67 & 0.58 & 0.93 & 1.01 & 1.53 \\ \hline SD & 1.13 & 0.16 & 0.13 & 0.09 & 0.19 & 0.23 & 0.29 \\ \hline p-valueD & 0.03 & 0.04 & 0.05 & 0.01 & 0.24 & 0.31 & 0.04 \\ \hline \end{tabular} \end{table}
PMC2717907_table_4
\begin{table} \centering \label{tab:tablelabel} \begin{tabular}{|l|l|l|} \hline \textbf{Gene/accession no} & \textbf{Forward sequence} & \textbf{Reverse sequence} \\ \hline FH/NM_000143.2 & TCTGGTCCTCGGTCAGGTCTG & GACAGTGACAGCAACATGGTTCC \\ \hline GLS/NM_014905 & GCACAGACATGGTTGGTATATTAG & AGAAGTCATACATGCCACAGG \\ \hline IDH3/NM_005530.2 & CAACTGCCCCTTCTCCTATCCC & AGCCCAAGCCTAAGCCCAAG \\ \hline MDH2/NM_005918.2 & CGGAGGTGGTCAAGGCTAAAG & CAGCGGTGTGGAGAAGTAGG \\ \hline OGDH/NM_002541.2 & GTGAGAATGGCGTGGACTAC & CGATTGATCCTGCGGTGATAC \\ \hline PC/NM_022172 & GCGTGTTTGACTACAGTGAG & TCTTGACCTCCTTGAACTTG \\ \hline SDH/NM_004168.2 & CATCGCATAAGAGCAAAGAAC & CCTTCCGTAATGAGACAACC \\ \hline 18S/NR_003286 & ATCAGATACCGTCGTAGTTCC & CCGTCAATT CCTTTAAGTTTCAG \\ \hline \end{tabular} \end{table}
PMC2717907_table_5
\begin{table} \centering \label{tab:tablelabel} \begin{tabular}{|l|l|l|l|l|l|l|l|} \hline \textbf{Patient} & \textbf{Tissuea} & \textbf{Env clone} & \textbf{MDM entryb} & \textbf{b12 IC50c} & \textbf{b6 IC50c} & \textbf{sCD4 IC50c} & \textbf{PS IC50c} \\ \hline \multirow{4}{*}{MACS2} & FL & 8–12 & 35478 & 3.37 & > 20 & 1.03 & 80.9 \\ \hline & 9–15 & 1765 & 1.15 & > 20 & 0.22 & 76.4 \\ \hline LN & 10–15 & 13001 & 0.99 & > 20 & > 20 & < 50 \\ \hline SP & 6–18 & 59224 & 10.89 & > 20 & > 20 & < 50 \\ \hline \multirow{4}{*}{MACS3} & FL & 12–27 & 13810 & > 20 & 1.87 & 1.10 & < 50 \\ \hline & 5 & 3402 & > 20 & 6.78 & 0.40 & < 50 \\ \hline LN & 2 & 1957 & > 20 & > 20 & 3.22 & < 50 \\ \hline & 20 & 16658 & > 20 & > 20 & > 20 & < 50 \\ \hline \multirow{3}{*}{UK1} & FL & 2–13b & 4378 & 0.05 & > 20 & 5.44 & < 50 \\ \hline SP & 6–20 & 812689 & 0.03 & > 20 & 2.39 & 124.2 \\ \hline & 20 & 35723 & 0.03 & > 20 & 0.27 & 230.2 \\ \hline \multirow{4}{*}{UK7} & FL & 6–24 & 9659 & 5.53 & > 20 & 7.68 & 145 \\ \hline & 1–4 & 13207 & 11.37 & > 20 & > 20 & 128 \\ \hline isolate & br34 & 496588 & 0.26 & > 20 & 0.45 & 332.2 \\ \hline LN & 7–6 & 5260 & 5.55 & > 20 & > 20 & < 50 \\ \hline \multirow{4}{*}{controls} & & YU2 & 38052 & 5.47 & > 20 & 1.14 & 72.4 \\ \hline & YU2 N386D & 114755 & 2.79 & > 20 & 0.45 & 115.2 \\ \hline & JRFL & 215305 & 0.18 & > 20 & 3.72 & 107.3 \\ \hline & JRFL N386D & 320642 & 0.09 & > 20 & 6.05 & 92.7 \\ \hline \end{tabular} \end{table}
PMC2717910_table_0
\begin{table} \centering \label{tab:tablelabel} \begin{tabular}{|l|l|l|} \hline \textbf{Stain} & \textbf{Stock solution} & \textbf{Stain}ing procedure \\ \hline \multirow{5}{*}{PTA} & 1\% (w/v) phosphotungstic acid in water & Mix 30 ml 1\% PTA solution + 70 ml absolute ethanol to make 0.3\% PTA in 70\% ethanol. Keeps indefinitely. \\ \hline & Take samples to 70\% ethanol. \\ \hline & \textbf{Stain} overnight or longer. \\ \hline & Change to 70\% ethanol. \textbf{Stain}ing is stable for months. \\ \hline & Scan samples in 70\% – 100\% ethanol \\ \hline \multirow{5}{*}{IKI} & 1\% iodine metal (I2) + 2\% potassium iodide (KI) in water & Dilute to 10\% in water just before use. \\ \hline & Rinse samples in water. \\ \hline & \textbf{Stain} overnight. \\ \hline & Wash in water. \\ \hline & Can be scanned in water or dehydrated to alcohol. \\ \hline \multirow{5}{*}{I2E, I2M} & 1\% iodine metal (I2) dissolved in 100\% ethanol (I2E) or methanol (I2M) & Use at full concentration or dilute in absolute alcohol. \\ \hline & Take samples to 100\% alcohol. \\ \hline & \textbf{Stain} overnight or longer. \\ \hline & Wash in alcohol. \\ \hline & \textbf{Stain} does not need to be completely washed out before scanning. \\ \hline \multirow{2}{*}{Osmium tetroxide} & standard EM post-fixation & Same as routine EM processing. \\ \hline & Osmium-stained samples can be scanned in resin blocks, with some loss of contrast. \\ \hline \end{tabular} \end{table}
PMC2717911_table_0
\begin{table} \centering \label{tab:tablelabel} \begin{tabular}{|l|l|} \hline \textbf{Fixative} & \textbf{Notes} \\ \hline \multirow{4}{*}{neutral-buffered formalin (10\% NBF)} & Formalin = 37\% formaldehyde solution (aq.). \\ \hline Normally used at 10\% dilution in phosphate buffer at pH 7.0 \\ \hline Commercial formalin usually contains about 10\% methanol. \\ \hline The most common, but rarely the best fixative. [23,24] \\ \hline \multirow{2}{*}{paraformaldehyde} & Polymerized formaldehyde, usually dissolved in buffer (e.g. PBS) at 4\% w/v when a chemically-controlled fixative is required. \\ \hline Action is generally similar to 10\% NBF. [23,24] \\ \hline gluteraldehyde & Strong cross-linking fixative, often prepared in cacodylate buffer or a less toxic alternative such as HEPES. Common fixative for electron microscopy. [23,24] \\ \hline \multirow{2}{*}{4F1G} & 4\% (or 3.7\%) formaldehyde + 1\% gluteraldehyde in phosphate buffer. \\ \hline Takes advantage of the faster penetration of formaldehyde and the superior fixing action of gluteraldehyde. Common fixation for electron microscopy. [25] \\ \hline \multirow{4}{*}{Bouin's fluid} & 75 parts (v/v) saturated aqueous picric acid, \\ \hline 25 parts formalin (37\% formaldehyde), \\ \hline 5 parts glacial acetic acid. \\ \hline A standard and excellent histological fixative. [24] \\ \hline \multirow{2}{*}{alcoholic Bouin's} & Refers to either a mixture of Bouin's fluid and ethanol (1:1), or to the fixative also known as Bouin-Duboscq- Brasil [24]. The two are similar in final composition. \\ \hline The alcoholic solutions penetrate more readily and are sometimes favored for arthropods. \\ \hline \multirow{3}{*}{glyoxal} & A cross-linking dialdehyde (OCHCHO) prepared in acidic buffers and marketed as formalin substitutes: Prefer (Anatech Ltd.; http://www.anatechltdusa.com) and Shandon Glyo-Fixx (Thermo Scientific; http:// www.thermo.com). \\ \hline Much less volatile and toxic than formaldehyde. \\ \hline Very good tissue preservation; especially good for immunostaining. \\ \hline \multirow{2}{*}{Dent's fixative} & 80\% methanol, 20\% DMSO \\ \hline Rapid dehydrating fixative. Expect some tissue shrinkage. Often used for immunostaining. \\ \hline \multirow{2}{*}{hot alcohol} & Samples are dropped into 70\% ethanol at about 60°C. \\ \hline Mainly used for fixing soft-bodied animals, such as insect larvae and pupae. \\ \hline \end{tabular} \end{table}
PMC2717911_table_1
\begin{table} \centering \label{tab:tablelabel} \begin{tabular}{|l|l|l|l|l|l|} \hline \textbf{Employment rights} & \multicolumn{5}{c|}{\textbf{Category of employment}} \\ \hline & \multicolumn{4}{c|}{\textbf{Non-permanent worker}} & \textbf{Permanent worker} \\ \hline & \textbf{Political appointment} & \textbf{Temporary contract} & \textbf{Subcontract} & \textbf{Trainee} & \textbf{Municipal Health Secretariat of the City of Belo Horizonte (SMSA-BH)} \\ \hline Entry & Nomination & Application & Application & Selection & Public competitive examination \\ \hline Working week & 40 hours exclusive contract. & 40 hours per week & 44 hours & 20 hours (trainee) 30 hours (subcontractor) & 20 hours or more \\ \hline Holidays & 25 working days & 20 days every 12 months (when less than 3 absences during the period) & 30 calendar days & Not specified & 25 working days \\ \hline 13th Salary & 1/12 year worked & 1/12 year worked & 1/12 year worked & Not specified & 1/12 year worked \\ \hline Sick leave & Time necessary for recuperation & Maximum of 2 days per month & Time necessary for recuperation & Not specified & Time necessary for recuperation \\ \hline Validity of contract or competitive examination & Duration of political mandate & 6 months, renewable 4 times & Indefinite & 6 months to 2 years (trainee) Indefinite (subcontractor) & Permanent after 730 days worked. \\ \hline Prior Notice & Not specified & 15 calendar days & 30 calendar days & Not specified & 30 calendar days \\ \hline Increase & According to Public Service increments & Not specified & Collective negotiations & Not specified & Collective negotiations \\ \hline \end{tabular} \end{table}
PMC2717912_table_0
\begin{table} \centering \label{tab:tablelabel} \begin{tabular}{|l|l|} \hline \textbf{Political appointees} & \textbf{Permanent workers} \\ \hline Leave & Leave \\ \hline Maternity & Maternity \\ \hline Adoption & Adoption \\ \hline Infant feeding & Infant feeding \\ \hline Paternity & Paternity \\ \hline Taking care of sick family member & Taking care of sick family member \\ \hline \multirow{6}{*}{Accident at work} & Accident at work \\ \hline Taking care of spouse or partner \\ \hline Military service \\ \hline Election candidate \\ \hline Personal business \\ \hline Professional training \\ \hline Entitlement & Entitlement \\ \hline \multirow{8}{*}{None} & Retirement \\ \hline Good attendance bonus \\ \hline Five-year length of service bonus \\ \hline Special workday for students \\ \hline Shorter workday to take care of dependent with special needs \\ \hline Transport voucher \\ \hline Meal voucher \\ \hline Time allowance for decease/death of relatives; blood donation, jury, military or administrative service; marriage; force majeure; voter registration or military conscription process and designated off-duty periods – compensation for hours worked in special cases. \\ \hline \end{tabular} \end{table}
PMC2717912_table_1
\begin{table} \centering \label{tab:tablelabel} \begin{tabular}{|l|l|} \hline \textbf{Year} & \textbf{Ratio of permanent to non-permanent workers} \\ \hline 2002 & 5.49:1 \\ \hline 2003 & 3.02:1 \\ \hline 2004 & 2.35:1 \\ \hline 2005 & 2.04:1 \\ \hline 2006 & 1,48:1 \\ \hline \end{tabular} \end{table}
PMC2717912_table_2
\begin{table} \centering \label{tab:tablelabel} \begin{tabular}{|l|l|} \hline \textbf{RNAeasy} & \textbf{Trizol} \\ \hline 8.1 & 7.3 \\ \hline 8.8 & 7.4 \\ \hline 8.2 & 6.7 \\ \hline \end{tabular} \end{table}
PMC2717914_table_0
\begin{table} \centering \label{tab:tablelabel} \begin{tabular}{|l|l|l|l|l|} \hline & \textbf{minus 70°C} & \textbf{Boonfix} & \textbf{B-RLT} & \textbf{RNAlater} \\ \hline \multirow{3}{*}{True cut (dry)} & 7.9 & 7.0 & 8.7 & 9.2 \\ \hline 8.7 & 7.3 & 8.6 & 8.5 \\ \hline 8.4 & 7.2 & 8.2 & 8.6 \\ \hline \multirow{3}{*}{Blind biopsy (NaCl)} & 8.1 & 8.1 & 9.1 & 9.1 \\ \hline 9.1 & 7.4 & 9.3 & 9.2 \\ \hline 9.0 & 7.1 & 9.0 & 8.5 \\ \hline \end{tabular} \end{table}
PMC2717914_table_1
\begin{table} \centering \label{tab:tablelabel} \begin{tabular}{|l|l|} \hline & \textbf{Mean score (SD)} \\ \hline Overall QoL and general health perceptions & 2.9 (0.8) \\ \hline Physical & 13.3 (3.2) \\ \hline Psychological & 13.7 (2.3) \\ \hline Independence & 14.5 (3.2) \\ \hline Social relationships & 13.9 (2.6) \\ \hline Environment & 12.3 (2.1) \\ \hline Spiritual & 12.8 (2.9) \\ \hline \end{tabular} \end{table}
PMC2717916_table_0
\begin{table} \centering \label{tab:tablelabel} \begin{tabular}{|l|l|l|l|l|l|l|l|} \hline \multicolumn{3}{c|}{\textbf{INPUT FACTORS (controlled on-line)}} & \multicolumn{5}{c|}{\textbf{MEASURABLE OUTPUT (measured offline)}} \\ \hline \textbf{T (°C)} & \textbf{pH} & \textbf{DO (\%)} & \textbf{OD595} & \textbf{RFU (mL-1)} & Specific RFU (mL-1 \textbf{OD595}-1) & Specific yield (ng mL-1 \textbf{OD595}-1) & SD; n = 3 (ng mL-1 \textbf{OD595}-1) \\ \hline 19 & 6 & 60 & 20.3 & 8651 & 426.2 & 127.9 & 3.2 \\ \hline 19 & 8 & 60 & 0.8 & 1015 & 1268.8 & 380.6 & 3.9 \\ \hline 19 & 7 & 30 & 13.1 & 10984 & 838.5 & 251.6 & 1.3 \\ \hline 19 & 7 & 90 & 12.4 & 9259 & 746.7 & 224.0 & 2.1 \\ \hline 24 & 6 & 30 & 24.4 & 8061 & 330.4 & 99.1 & 1.6 \\ \hline 24 & 6 & 90 & 16.2 & 11951 & 737.7 & 221.3 & 5.6 \\ \hline 24 & 8 & 30 & 4.7 & 1564 & 332.8 & 99.8 & 1.1 \\ \hline 24 & 8 & 90 & 1.3 & 1954 & 1503.1 & 450.9 & 1.3 \\ \hline 24 & 7 & 60 & 17.6 & 21382 & 1214.9 & 364.5 & 10.1 \\ \hline 29 & 7 & 30 & 24.8 & 25392 & 1023.9 & 307.2 & 0.2 \\ \hline 29 & 8 & 60 & 4.4 & 1413 & 321.1 & 96.3 & 1.5 \\ \hline 29 & 6 & 60 & 21.7 & 10349 & 476.9 & 143.1 & 0.3 \\ \hline 29 & 7 & 90 & 15.1 & 17495 & 1158.6 & 347.6 & 3.5 \\ \hline \end{tabular} \end{table}
PMC2717918_table_0
\begin{table} \centering \label{tab:tablelabel} \begin{tabular}{|l|l|l|l|l|l|} \hline \textbf{Source} & \textbf{Degrees of Freedom} & \textbf{Sum of Squares} & \textbf{Mean Square} & \textbf{F statistic} & \textbf{p value} \\ \hline Regression & 6 & 1288405 & 214734 & 1.96 & 0.217 \\ \hline Linear & 3 & 586988 & 223083 & 2.04 & 0.21 \\ \hline Square & 1 & 326196 & 326196 & 2.98 & 0.135 \\ \hline Interaction & 2 & 375221 & 187610 & 1.71 & 0.258 \\ \hline Residual & 6 & 657203 & 109534 \\ \hline Total & 12 & 1945608 \\ \hline \end{tabular} \end{table}
PMC2717918_table_1
\begin{table} \centering \label{tab:tablelabel} \begin{tabular}{|l|l|l|} \hline \textbf{T(°C)} & \textbf{pH} & \textbf{DO(\%)} \\ \hline 20 & 7.5 & 60 \\ \hline 20 & 7.7 & 80 \\ \hline 27 & 8 & 50 \\ \hline 28 & 7.5 & 90 \\ \hline 28 & 6 & 80 \\ \hline 23.6 & 7.25 & 60 \\ \hline 27.5 & 6.7 & 80 \\ \hline 27.5 & 6.5 & 60 \\ \hline 27.5 & 6.3 & 60 \\ \hline 21.5 & 7.6 & 20 \\ \hline 21.5 & 7.6 & 40 \\ \hline 21.5 & 7.6 & 60 \\ \hline \end{tabular} \end{table}
PMC2717918_table_2
\begin{table} \centering \label{tab:tablelabel} \begin{tabular}{|l|l|l|l|} \hline \textbf{Time (min)} & \textbf{T (°C)} & \textbf{pH} & \textbf{DO (\%)} \\ \hline 0 & 30 & 6 & 30 \\ \hline 15 & 28 & 6.4 & 45 \\ \hline 30 & 25 & 6.8 & 60 \\ \hline 45 & 23 & 7.2 & 75 \\ \hline 60 & 21.5 & 7.6 & 90 \\ \hline 75 & 21.5 & 7.6 & 90 \\ \hline \end{tabular} \end{table}
PMC2717918_table_3
\begin{table} \centering \label{tab:tablelabel} \begin{tabular}{|l|l|l|} \hline \textbf{No. (sample code) (bleeding date)} & \textbf{PR3-ANCA (U/ml)} & \textbf{MPO-ANCA (U/ml)} \\ \hline 1. (Q9-40) (5/9/1996) & 29.2 & < 1.3 \\ \hline (R9-10) (9/27/1996) & 19.1 & < 1.3 \\ \hline (S9-31) (11/21/1996) & 10.7 & < 1.3 \\ \hline 2. (R9-7) (9/27/1996) & 3.8 & < 1.3 \\ \hline (S9-29) (11/19/1996) & 3.5 & < 1.3 \\ \hline 3. (S9-32) (11/21/1996) & 18.8 & < 1.3 \\ \hline 4. (D10-41) (4/4/2000) & 14.0 & < 1.3 \\ \hline 5. (M10-24) (2/3/2004) & < 1.3 & < 1.3 \\ \hline 6. (M10-28) (2/3/2004) & < 1.3 & < 1.3 \\ \hline 7. (G10-37) (5/15/2002) & < 1.3 & < 1.3 \\ \hline 8. (H10-51) (9/2/2002) & < 1.3 & < 1.3 \\ \hline \end{tabular} \end{table}
PMC2717921_table_0
\begin{table} \centering \label{tab:tablelabel} \begin{tabular}{|l|l|l|} \hline & \textbf{Patient without palsy (n = 56)} & \textbf{Patient with Palsy (n = 18)} \\ \hline Sex (M/F) & 36/20 & 12/6 \\ \hline Mean age at surgery (years) & 60.63 & 61.61 \\ \hline Duration of symptom before operation (months) & 12.42 & 15.06 \\ \hline Disease etiology (\%) \\ \hline - CSM & 40 (71.4) & 12 (66.7) \\ \hline - OPLL & 11 (19.6) & 5 (27.8) \\ \hline - PID & 5 (8.9) & 1 (5.6) \\ \hline Type of operation (\%) \\ \hline - Laminoplasty & 53 (94.6) & 15 (83.3) \\ \hline - Posterior decompression with internal fixation & 3 (5.4) & 3 (16.7) \\ \hline Extent of decompression (\%) \\ \hline - C2–C7 & 1 (1.8) & 0 (0) \\ \hline - C3–C7 & 25 (44.6) & 9 (50) \\ \hline - C3–C6 & 21 (37.5) & 8 (44.4) \\ \hline - C3–C5 & 4 (7.1) & 0 (0) \\ \hline - C4–C7 & 3 (5.4) & 0 (0) \\ \hline - C4–C6 & 2 (3.6) & 1 (5.6) \\ \hline Mean Preoperative JOA score & 10.55 & 11.22 \\ \hline Mean Postoperative JOA score & 13.66 & 14.22 \\ \hline Recovery rate (\%) & 52.37 & 48.34 \\ \hline \end{tabular} \end{table}
PMC2717922_table_0
\begin{table} \centering \label{tab:tablelabel} \begin{tabular}{|l|l|} \hline \textbf{JOA SCORE} \\ \hline \multirow{5}{*}{I. Motor function of the upper extremity} & 0. Impossible to eat with chopsticks or spoon \\ \hline 1. Possible to ear with spoon, but not with chopsticks \\ \hline 2. Possible to eat with chopsticks, but inadequate \\ \hline 3. Possible to eat with chopsticks, but awkward \\ \hline 4. Normal \\ \hline \multirow{5}{*}{II. Motor function of the lower extremity} & 0. Impossible to walk \\ \hline 1. Needs cane or aid on flat ground \\ \hline 2. Needs cane or aid only on stairs \\ \hline 3. Possible to walk without cane or aid but slowly \\ \hline 4. Normal \\ \hline \multirow{6}{*}{III. Sensory function} & A. Upper extremity \\ \hline 0. Apparent sensory loss \\ \hline 1. Minimal sensory loss \\ \hline 2. Normal \\ \hline B. Lower extremity (same as A) \\ \hline Trunk (same as A) \\ \hline \multirow{4}{*}{IV. Bladder function} & 0. Complete retention \\ \hline 1. Severe disturbance (sense of retention, dribbling, incomplete continence) \\ \hline 2. Mild disturbance (urinary frequency, urinary hesitancy) \\ \hline 3. Normal \\ \hline \end{tabular} \end{table}
PMC2717922_table_1
\begin{table} \centering \label{tab:tablelabel} \begin{tabular}{|l|l|l|l|l|l|l|l|l|l|l|} \hline \textbf{Case no.} & \textbf{Age (yr)/Sex} & \textbf{Etiology} & \multicolumn{3}{c|}{\textbf{Presentation}} & \textbf{Onset (days)} & \textbf{Duration of recovery (days)} & \textbf{Laterality} & \textbf{Level of involvement} & \textbf{HIA on preop. MRI} \\ \hline & & & \textbf{Dysesthesia} & \textbf{Sensory deficit} & \textbf{Motor deficit (MMT)} \\ \hline 1 & 72/M & CSM & Yes & No & No & 5 & 2 & Left & C5 & - \\ \hline 2 & 80/M & CSM & Yes & No & Yes (4 to -3) & 7 & 42 & Left & C5 & C3/4, C6/7 \\ \hline 3 & 71/F & CSM & Yes & No & Yes (5 to 4) & 2 & 42 & Bilateral & C5, C8 & C5 \\ \hline 4 & 54/F & CSM & Yes & No & No & 1 & 8 & Left & C5 & C6/7 \\ \hline 5 & 50/M & OPLL & Yes & Yes & Yes (5 to 3) & 1 & 31 & Right & C6, C7 & C3/4 \\ \hline 6 & 74/M & CSM & Yes & No & No & 3 & 95 & Right & C5 & C3/4, C5/6 \\ \hline 7 & 51/M & CSM & Yes & No & Yes (5 to 4) & 4 & 5 & Right & C5–7 & C4/5 \\ \hline 8 & 50/M & PID & Yes & No & No & 3 & 1 & Right & C5 & C3–5 \\ \hline 9 & 54/M & CSM & Yes & No & No & 6 & 1 & Right & C5 & - \\ \hline 10 & 78/M & CSM & Yes & No & Yes (4 to -3) & 1 & 21 & Bilateral & C5–6 & C5/6 \\ \hline 11 & 49/F & OPLL & Yes & No & No & 2 & 2 & Left & C5 & - \\ \hline 12 & 68/F & OPLL & Yes & Yes & Yes (5-4) & 1 & 182 & Bilateral & C5, C8, T1 & - \\ \hline 13 & 61/F & OPLL & Yes & No & No & 1 & 15 & Left & C5 & C4/5 \\ \hline 14 & 49/M & CSM & Yes & No & No & 1 & 27 & Bilateral & C5 & - \\ \hline 15 & 59/F & OPLL & Yes & No & No & 1 & 11 & Bilateral & C5 & - \\ \hline 16 & 84/M & CSM & No & No & Yes (4-3) & 4 & 15 & Left & C5–7 & C3/4, C6/7 \\ \hline 17 & 60/M & CSM & Yes & No & No & 2 & 5 & Right & C5 & C4/5, C5–6 \\ \hline 18 & 45/M & CSM & Yes & No & Yes (5-0) & 1 & 120 & Bilateral & C5-T1 & C3/4, C6/7 \\ \hline \end{tabular} \end{table}
PMC2717922_table_2
\begin{table} \centering \label{tab:tablelabel} \begin{tabular}{|l|l|l|l|} \hline & \textbf{\textbf{P}ure dysesthesia (n = 10)} & \textbf{Dysesthesia with motor deficit (n = 8)} & \textbf{P} \\ \hline Mean age (years) & 58.2 & 65.9 & 0.199 \\ \hline Mean recovery time (days) & 16.7 & 57.3 & 0.082 \\ \hline Sex (M/F) & 6:4 & 6:2 & 0.502 \\ \hline HIA in T2-weighted MRI (\%) & 5 (50) & 7 (87.5) & 0.152 \\ \hline \end{tabular} \end{table}
PMC2717922_table_3
\begin{table} \centering \label{tab:tablelabel} \begin{tabular}{|l|l|l|l|} \hline & \textbf{\textbf{P}atient without palsy (n = 56)} & \textbf{\textbf{P}atient with palsy (n = 18)} & \textbf{P} \\ \hline \textbf{P}avlov ratio (mean) \\ \hline C3 & 0.7125 & 0.6916 & 0.363 \\ \hline C4 & 0.6870 & 0.6701 & 0.495 \\ \hline C5 & 0.6836 & 0.6805 & 0.890 \\ \hline C6 & 0.7198 & 0.6783 & 0.058 \\ \hline Average & 0.7017 & 0.6804 & 0.271 \\ \hline \end{tabular} \end{table}
PMC2717922_table_4
\begin{table} \centering \label{tab:tablelabel} \begin{tabular}{|l|l|l|l|l|} \hline & \textbf{Patient without \textbf{p}alsy (n = 56)} & \textbf{Patient with \textbf{p}alsy (n = 18)} & \textbf{OR} & \textbf{p} \\ \hline Average Pavlov ratio < 0.65 & 10 (17.9) & 8 (44.4) & 3.68 & 0.027 \\ \hline Level of com\textbf{p}ression in Preo\textbf{p}erative MRI (\%) \\ \hline C2/3 (\%) & 3 (5.4) & 1 (5.6) & 1.039 & 0.974 \\ \hline C3/4 (\%) & 32 (57.1) & 16 (88.9) & 6 & 0.025 \\ \hline C4/5 (\%) & 40 (71.4) & 16 (88.9) & 3.2 & 0.149 \\ \hline C5/6 (\%) & 42 (75.0) & 10 (55.6) & 0.417 & 0.122 \\ \hline C6/7 (\%) & 25 (44.6) & 10 (55.6) & 1.55 & 0.421 \\ \hline C7/T1 (\%) & 1 (1.8) & 0 (0) \\ \hline 3 or more com\textbf{p}ression levels in MRI (\%) & 27 (48.2) & 13 (72.2) & 2.79 & 0.082 \\ \hline HIA in T2 weighted MRI image (\%) & 44 (78.6) & 11 (61.1) & 0.955 & 0.943 \\ \hline \end{tabular} \end{table}
PMC2717922_table_5
\begin{table} \centering \label{tab:tablelabel} \begin{tabular}{|l|l|l|l|} \hline & \textbf{High expressing (LA/LA)} & \textbf{Intermediate expressing (LA/SA)} & \textbf{Low expressing (SA/SA and LG/SA)} \\ \hline Male & 4 & 3 & 5 \\ \hline Female & 8 & 14 & 9 \\ \hline Total & 12 & 17 & 14 \\ \hline \end{tabular} \end{table}
PMC2717925_table_0
\begin{table} \centering \label{tab:tablelabel} \begin{tabular}{|l|l|l|l|} \hline & \textbf{Exercisers n = 52} & \textbf{Non-exercisers n = 69} & \textbf{Total MS sample n = 121} \\ \hline Age (yr) & 50 $\pm$ 10 & 50 $\pm$ 11 & 50 $\pm$ 10 \\ \hline Sex (\% male) & 23.1 & 15.9 & 19.0 \\ \hline Disease duration (yr) & 12 $\pm$ 8 & 11 $\pm$ 8 & 12 $\pm$ 8 \\ \hline Disease Steps Score (\%) \\ \hline 0 & 15.4 & 8.7 & 11.6 \\ \hline 1 & 26.9 & 24.6 & 25.6 \\ \hline 2 & 17.3 & 13.0 & 14.9 \\ \hline 3 & 5.8 & 11.6 & 9.1 \\ \hline 4 & 19.2 & 17.4 & 18.2 \\ \hline 5 & 11.5 & 11.6 & 11.6 \\ \hline 6 & 3.8 & 13.0 & 9.1 \\ \hline MSIS-29 & 61 $\pm$ 18** & 77 $\pm$ 26 & 70 $\pm$ 24 \\ \hline Disease Course (\%)* \\ \hline Relapsing-remitting & 51.9 & 55.1 & 53.7 \\ \hline Secondary progressive & 23.1 & 13.0 & 17.4 \\ \hline Primary progressive & 1.9 & 17.4 & 10.7 \\ \hline Progressive relapsing & 0.0 & 4.3 & 2.5 \\ \hline Unknown & 23.1 & 10.1 & 15.7 \\ \hline \end{tabular} \end{table}
PMC2717927_table_0
\begin{table} \centering \label{tab:tablelabel} \begin{tabular}{|l|l|l|l|l|l|} \hline & \textbf{BDI} & \textbf{SF36PF} & \textbf{SF36RP} & \textbf{SF36BP} & \textbf{SFGH} \\ \hline Exercise Status & 5.632* & 12.983** & 1.236 & 2.149 & 9.325** \\ \hline Disease Severity & 1.159 & 39.953** & 10.437** & 4.921** & 2.810* \\ \hline \multirow{2}{*}{Interaction effect} & 0.822 & 2.527* & 0.988 & 2.754* & 2.004 \\ \hline SF36VT & SF36SF & SF36RE & SF36MH & SF36PCSS \\ \hline Exercise Status & 5.631* & 7.440** & 3.074 & 7.398** & 5.532* \\ \hline Disease Severity & 3.752** & 1.527 & 0.791 & 0.839 & 23.693** \\ \hline \multirow{2}{*}{Interaction effect} & 1.191 & 0.406 & 0.430 & 0.450 & 2.314* \\ \hline SF36MCSS & MFISphy & MFIScog & MFISpsy & MFIStot \\ \hline Exercise Status & 5.436* & 9.247** & 1.153 & 4.547** & 1.549 \\ \hline Disease Severity & 0.671 & 10.624** & 3.986** & 10.489** & 7.160** \\ \hline Interaction effect & 0.202 & 0.707 & 1.813 & 0.486 & 0.413 \\ \hline \end{tabular} \end{table}
PMC2717927_table_1
\begin{table} \centering \label{tab:tablelabel} \begin{tabular}{|l|l|l|l|l|} \hline & \multicolumn{2}{c|}{\textbf{H. sapiens versus M. musculus \% sequence identity}} & \multicolumn{2}{c|}{\textbf{H. sapiens versus G. gallus \% sequence identity}} \\ \hline & \textbf{\textbf{Whole length}} & \textbf{\textbf{Signal peptide}} & \textbf{\textbf{Whole length}} & \textbf{\textbf{Signal peptide}} \\ \hline AMH & 74.0 & 40.0 & 45.1 & 43.3 \\ \hline BMP2 & 92.4 & 93.3 & 81.3 & 66.7 \\ \hline BMP3 & 81.1 & 63.3 & 67.2 & 36.7 \\ \hline BMP4 & 97.5 & 100.0 & 85.3 & 90.0 \\ \hline BMP5 & 93.2 & 86.7 & 92.7 & 70.0 \\ \hline BMP6 & 91.9 & 96.7 & 85.1 & 16.7 \\ \hline BMP7 & 97.7 & 100.0 & 91.4 & 30.0 \\ \hline BMP9 (GDF2) & 80.4 & 53.3 & 61.8 & 30.0 \\ \hline BMP10 & 85.5 & 73.3 & 74.7 & 46.7 \\ \hline BMP14(GDF5) & 92.3 & 90.0 & 70.6 & 33.3 \\ \hline BMP15 & 64.2 & 60.0 & 47.0 & 13.3 \\ \hline GDF3 & 71.1 & 33.3 & 48.9 & 33.3 \\ \hline MSTN (GDF8) & 96.3 & 80.0 & 92.0 & 53.3 \\ \hline GDF9 & 74.1 & 66.7 & 589 & 20.0 \\ \hline \end{tabular} \end{table}
PMC2717928_table_0
\begin{table} \centering \label{tab:tablelabel} \begin{tabular}{|l|l|l|l|l|l|l|l|} \hline \textbf{Year} & \textbf{1\%} & \textbf{2\%} & \textbf{5\%} & \textbf{7\%} & \textbf{10\%} & \textbf{20\%} & \textbf{30\%} \\ \hline 2002 & 0.60 & 0.56 & 0.49 & 0.49 & 0.42 & 0.42 & 0.41 \\ \hline 2003 & 0.66 & 0.64 & 0.60 & 0.62 & 0.62 & 0.60 & 0.65 \\ \hline 2004 & 0.51 & 0.50 & 0.43 & 0.40 & 0.39 & 0.26 & 0.24 \\ \hline 2005 & 0.51 & 0.48 & 0.46 & 0.45 & 0.36 & 0.40 & 0.36 \\ \hline 2006 & 0.63 & 0.57 & 0.54 & 0.52 & 0.46 & 0.41 & 0.57 \\ \hline 2007 & 0.53 & 0.55 & 0.49 & 0.48 & 0.47 & 0.45 & 0.42 \\ \hline 2008 & 0.43 & 0.47 & 0.33 & 0.35 & 0.29 & 0.27 & 0.34 \\ \hline All years & 0.72 & 0.72 & 0.64 & 0.63 & 0.64 & 0.60 & 0.60 \\ \hline Overall average & 0.58 & 0.56 & 0.50 & 0.49 & 0.46 & 0.43 & 0.45 \\ \hline \end{tabular} \end{table}
PMC2717929_table_0
\begin{table} \centering \label{tab:tablelabel} \begin{tabular}{|l|l|l|l|} \hline \textbf{Treatment} & \multicolumn{3}{c|}{\textbf{Maximal changes in}} \\ \hline & \textbf{MSAP (mmHg)} & \textbf{HR (bpm)} & \textbf{Power Density (mmHg2)} \\ \hline aCSF & +3.3 $\pm$ 0.4 & +4.9 $\pm$ 0.6 & +0.7 $\pm$ 0.5 \\ \hline ICI 182780 (0.25 pmol) & +3.3 $\pm$ 0.6 & +5.5 $\pm$ 0.8 & +0.7 $\pm$ 0.5 \\ \hline ICI 182780 (0.5 pmol) & +2.5 $\pm$ 0.5 & +3.5 $\pm$ 0.8 & +0.6 $\pm$ 0.6 \\ \hline R,R-THC (50 pmol) & +6.4 $\pm$ 0.6 & +6.5 $\pm$ 1.0 & +0.8 $\pm$ 0.4 \\ \hline MPP (1 nmol) & +6.1 $\pm$ 0.8 & +6.6 $\pm$ 0.8 & +0.9 $\pm$ 0.7 \\ \hline L-NAME (5 nmol) & +3.8 $\pm$ 0.6 & +5.6 $\pm$ 0.6 & +0.9 $\pm$ 0.6 \\ \hline SMT (25 pmol) & +3.7 $\pm$ 0.8 & +5.3 $\pm$ 0.8 & +0.7 $\pm$ 0.5 \\ \hline 7-NI (0.5 pmol) & -2.7 $\pm$ 0.8 & -3.3 $\pm$ 0.5 & -0.6 $\pm$ 0.8 \\ \hline L-NIO (2.5 pmol) & -1.9 $\pm$ 0.8 & -3.6 $\pm$ 0.7 & -1.0 $\pm$ 0.6 \\ \hline \end{tabular} \end{table}
PMC2717931_table_0
\begin{table} \centering \label{tab:tablelabel} \begin{tabular}{|l|l|l|l|l|l|l|l|} \hline \textbf{N} & \textbf{AGE} & \textbf{SIDE} & GE\textbf{N}DER & \textbf{CEAP} & \textbf{Total Vol.} & \textbf{Volume Post-rest} & \textbf{Volume Post-exercise} \\ \hline 01- & 60 & R & F & C3 & 3570 & -120 & -1–145 \\ \hline 02- & 47 & L & F & C5 & 4845 & -25 & -90 \\ \hline 03- & 66 & L & F & C5 & 3390 & -40 & ---125 \\ \hline 04- & 40 & L & F & C3 & 3040 & -50 & -88 \\ \hline 05- & 50 & R & F & C3 & 3970 & -80 & -110 \\ \hline 06- & 45 & L & F & C3 & 4480 & -100 & -140 \\ \hline 07- & 56 & R & F & C3 & 3902 & -65 & -230 \\ \hline 08- & 74 & L & F & C4 & 3275 & -40 & -69 \\ \hline 09- & 49 & L & F & C4 & 4060 & -280 & -216 \\ \hline 10- & 53 & R & M & C5 & 3410 & -113 & -120 \\ \hline 11- & 57 & R & F & C4 & 2990 & -160 & -190 \\ \hline 12- & 45 & L & F & C4 & 4310 & -65 & -95 \\ \hline 13- & 50 & R & F & C3 & 4121 & -20 & -132 \\ \hline 14- & 69 & L & F & C5 & 4200 & -60 & -90 \\ \hline 15- & 61 & R & F & C5 & 4775 & -65 & -115 \\ \hline 16- & 46 & L & F & C4 & 4910 & -100 & -110 \\ \hline 17- & 72 & R & M & C5 & 5420 & -164 & -245 \\ \hline 18- & 39 & R & F & C5 & 3431 & -66 & -278 \\ \hline 19- & 63 & L & F & C5 & 4960 & -85 & -140 \\ \hline 20- & 63 & R & F & C4 & 3610 & -30 & -90 \\ \hline 21- & - & L & F & C3 & 3270 & -40 & -90 \\ \hline 22- & 38 & R & F & C5 & 3360 & -90 & -30 \\ \hline 23- & - & L & F & C4 & 3220 & -100 & -95 \\ \hline 24- & 60 & R & F & C4 & 4700 & -80 & -90 \\ \hline 25- & - & L & F & C5 & 4490 & -80 & -110 \\ \hline 26- & 54 & R & F & C3 & 4700 & -70 & -20 \\ \hline 27- & - & L & F & C4 & 4490 & -395 & -420 \\ \hline 28- & 36 & R & M & C5 & 4775 & -20 & -120 \\ \hline \end{tabular} \end{table}
PMC2717934_table_0
\begin{table} \centering \label{tab:tablelabel} \begin{tabular}{|l|l|l|l|l|l|l|l|l|} \hline & \textbf{Geometric Mean} & \multicolumn{7}{c|}{\textbf{Selected Percentiles}} \\ \hline & & \textbf{10th} & \textbf{25th} & \textbf{50th} & \textbf{75th} & \textbf{90th} & \textbf{95th} & \textbf{Max.} \\ \hline HCB \\ \hline Serum & 0.093 & 0.051 & 0.069 & 0.090 & 0.114 & 0.151 & 0.195 & 2.31 \\ \hline FF & 0.032 & 0.017 & 0.025 & 0.035 & 0.044 & 0.057 & 0.072 & 0.588 \\ \hline Oxychlordane \\ \hline Serum & 0.045 & 0.024 & 0.033 & 0.046 & 0.062 & 0.088 & 0.094 & 0.156 \\ \hline FF & 0.011 & 0.006 & 0.008 & 0.012 & 0.014 & 0.018 & 0.023 & 0.036 \\ \hline Trans-nonachlor \\ \hline Serum & 0.090 & 0.045 & 0.068 & 0.092 & 0.128 & 0.168 & 0.205 & 0.485 \\ \hline FF & 0.018 & 0.008 & 0.013 & 0.020 & 0.027 & 0.031 & 0.040 & 0.138 \\ \hline Mirex \\ \hline Serum & 0.014 & 0.006 & 0.010 & 0.014 & 0.022 & 0.031 & 0.051 & 0.100 \\ \hline FF & 0.004 & 0.001 & 0.002 & 0.004 & 0.006 & 0.008 & 0.009 & 0.040 \\ \hline p,p'-DDE \\ \hline Serum & 1.23 & 0.430 & 0.700 & 1.08 & 1.81 & 3.93 & 8.75 & 24.2 \\ \hline FF & 0.384 & 0.123 & 0.223 & 0.363 & 0.878 & 1.85 & 4.26 & 6.74 \\ \hline p,p'-DDT \\ \hline Serum & 0.065 & 0.030 & 0.040 & 0.063 & 0.086 & 0.119 & 0.346 & 1.98 \\ \hline FF & 0.013 & 0.005 & 0.009 & 0.014 & 0.019 & 0.028 & 0.047 & 0.116 \\ \hline PCB 118 \\ \hline Serum & 0.091 & 0.041 & 0.056 & 0.088 & 0.145 & 0.205 & 0.320 & 0.540 \\ \hline FF & 0.028 & 0.010 & 0.017 & 0.032 & 0.047 & 0.073 & 0.096 & 0.132 \\ \hline PCB 138 \\ \hline Serum & 0.149 & 0.073 & 0.103 & 0.153 & 0.206 & 0.295 & 0.313 & 1.11 \\ \hline FF & 0.043 & 0.019 & 0.034 & 0.047 & 0.071 & 0.100 & 0.139 & 0.380 \\ \hline PCB 153 \\ \hline Serum & 0.257 & 0.119 & 0.181 & 0.260 & 0.358 & 0.521 & 0.591 & 2.33 \\ \hline FF & 0.064 & 0.024 & 0.047 & 0.072 & 0.110 & 0.148 & 0.211 & 0.778 \\ \hline PCB 180 \\ \hline Serum & 0.159 & 0.073 & 0.119 & 0.168 & 0.229 & 0.293 & 0.350 & 1.98 \\ \hline FF & 0.039 & 0.013 & 0.021 & 0.045 & 0.060 & 0.100 & 0.111 & 0.640 \\ \hline ΣPCB \\ \hline Serum & 1.41 & 0.754 & 1.06 & 1.40 & 1.84 & 2.49 & 3.01 & 10.3 \\ \hline FF & 0.350 & 0.127 & 0.252 & 0.384 & 0.534 & 0.709 & 0.970 & 3.23 \\ \hline \end{tabular} \end{table}
PMC2717935_table_0
\begin{table} \centering \label{tab:tablelabel} \begin{tabular}{|l|l|l|l|l|l|l|l|l|l|l|} \hline & \textbf{Molecular weight} & \textbf{Mean} & \multicolumn{8}{c|}{\textbf{Selected Percentiles}} \\ \hline & & & \textbf{Min.} & \textbf{10th} & \textbf{25th} & \textbf{50th} & \textbf{75th} & \textbf{90th} & \textbf{95th} & \textbf{Max.} \\ \hline HCB & 285 & 0.39 & 0.13 & 0.22 & 0.29 & 0.37 & 0.49 & 0.55 & 0.60 & 0.69 \\ \hline p,p'-DDE & 318 & 0.32 & 0.03 & 0.18 & 0.24 & 0.32 & 0.41 & 0.46 & 0.49 & 0.55 \\ \hline PCB 118 & 326 & 0.32 & 0.06 & 0.18 & 0.22 & 0.30 & 0.39 & 0.46 & 0.48 & 1.38* \\ \hline p,p'-DDT & 355 & 0.22 & 0.02 & 0.11 & 0.14 & 0.22 & 0.27 & 0.32 & 0.36 & 0.47 \\ \hline PCB 138 & 361 & 0.31 & 0.04 & 0.17 & 0.24 & 0.30 & 0.37 & 0.43 & 0.51 & 0.99* \\ \hline PCB 153 & 361 & 0.27 & 0.03 & 0.14 & 0.20 & 0.25 & 0.34 & 0.39 & 0.41 & 0.79* \\ \hline PCB 180 & 395 & 0.25 & 0.02 & 0.12 & 0.18 & 0.25 & 0.31 & 0.40 & 0.41 & 0.94* \\ \hline Oxychlordane & 426 & 0.24 & 0.06 & 0.12 & 0.17 & 0.24 & 0.29 & 0.35 & 0.37 & 0.52 \\ \hline Trans-nonachlor & 444 & 0.21 & 0.05 & 0.10 & 0.16 & 0.20 & 0.25 & 0.29 & 0.32 & 0.71* \\ \hline Mirex & 546 & 0.24 & 0.06 & 0.11 & 0.17 & 0.22 & 0.30 & 0.39 & 0.42 & 0.54 \\ \hline ΣPCB & & 0.27 & 0.06 & 0.14 & 0.19 & 0.26 & 0.33 & 0.38 & 0.42 & 0.97* \\ \hline \end{tabular} \end{table}
PMC2717935_table_1
\begin{table} \centering \label{tab:tablelabel} \begin{tabular}{|l|l|l|l|l|} \hline & \multicolumn{2}{c|}{\textbf{Wet-weight concentrations}} & \multicolumn{2}{c|}{\textbf{Lipid-standardized}} \\ \hline & \textbf{All samples; n = 266} & \textbf{Excluding baseline; n = 178} & \textbf{All samples; n = 173} & \textbf{Excluding baseline; n = 105} \\ \hline HCB & 0.95 (0.93, 0.96) & 0.97 (0.95, 0.98) & 0.95 (0.92, 0.97) & 0.97 (0.95, 0.98) \\ \hline Oxychlordane & 0.85 (0.80, 0.90) & 0.91 (0.86, 0.94) & 0.90 (0.85, 0.93) & 0.93 (0.88, 0.96) \\ \hline Transnonachlor & 0.88 (0.83, 0.91) & 0.94 (0.92, 0.96) & 0.95 (0.92, 0.97) & 0.94 (0.90, 0.97) \\ \hline Mirex & 0.88 (0.83, 0.91) & 0.95 (0.93, 0.97) & 0.90 (0.85, 0.93) & 0.95 (0.92, 0.97) \\ \hline p,p'-DDE & 0.98 (0.97, 0.99) & 0.98 (0.97, 0.99) & 0.98 (0.97, 0.99) & 0.98 (0.97, 0.99) \\ \hline p,p'-DDT & 0.93 (0.91, 0.95) & 0.96 (0.95, 0.98) & 0.95 (0.92, 0.97) & 0.96 (0.92, 0.98) \\ \hline PCB 118 & 0.92 (0.89, 0.94) & 0.97 (0.96, 0.98) & 0.97 (0.95, 0.98) & 0.97 (0.95, 0.99) \\ \hline PCB 138 & 0.91 (0.87, 0.93) & 0.96 (0.94, 0.97) & 0.96 (0.94, 0.98) & 0.97 (0.95, 0.98) \\ \hline PCB 153 & 0.91 (0.88, 0.94) & 0.96 (0.93, 0.97) & 0.97 (0.95, 0.98) & 0.97 (0.94, 0.98) \\ \hline PCB 180 & 0.91 (0.87, 0.93) & 0.95 (0.93, 0.97) & 0.96 (0.94, 0.97) & 0.97 (0.95, 0.98) \\ \hline Sum PCB & 0.83 (0.77, 0.88) & 0.92 (0.89, 0.95) & 0.88 (0.83, 0.92) & 0.93 (0.88, 0.96) \\ \hline Cholesterolb & 0.58 (0.43, 0.71) & 0.67 (0.49, 0.82) \\ \hline Triglyceridesb & 0.85 (0.78, 0.90) & 0.86 (0.77, 0.92) \\ \hline Total lipidsb & 0.78 (0.69, 0.86) & 0.83 (0.71, 0.90) \\ \hline \end{tabular} \end{table}
PMC2717935_table_2
\begin{table} \centering \label{tab:tablelabel} \begin{tabular}{|l|l|l|l|l|l|l|} \hline & \multicolumn{3}{c|}{\textbf{Follicular fluid}} & \multicolumn{3}{c|}{\textbf{Serum}} \\ \hline & \textbf{Phase 1 (1994–1998); n = 31} & \textbf{Phase 2 (1999–2003); n = 41} & \textbf{\textbf{p-value}} & \textbf{Phase 1 (1994–1998); n = 56} & \textbf{Phase 2 (1999–2003); n = 54} & \textbf{\textbf{p-value}} \\ \hline HCB & 0.036 & 0.029 & 0.2 & 0.104 & 0.083 & 0.05 \\ \hline Oxychlordane & 0.013 & 0.010 & 0.02 & 0.052 & 0.039 & 0.003 \\ \hline Trans-nonachlor & 0.021 & 0.016 & 0.09 & 0.106 & 0.075 & 0.001 \\ \hline Mirex & 0.004 & 0.003 & 0.10 & 0.015 & 0.013 & 0.2 \\ \hline p,p'-DDE & 0.48 & 0.32 & 0.2 & 1.53 & 0.98 & 0.01 \\ \hline p,p'-DDT & 0.017 & 0.010 & 0.02 & 0.086 & 0.049 & <0.0001 \\ \hline PCB 118 & 0.034 & 0.025 & 0.08 & 0.106 & 0.079 & 0.02 \\ \hline PCB 138 & 0.056 & 0.035 & 0.04 & 0.181 & 0.122 & 0.0004 \\ \hline PCB 153 & 0.086 & 0.052 & 0.02 & 0.306 & 0.214 & 0.0002 \\ \hline PCB 180 & 0.051 & 0.032 & 0.01 & 0.187 & 0.134 & 0.005 \\ \hline Sum PCB & 0.47 & 0.28 & 0.004 & 1.57 & 1.26 & 0.03 \\ \hline \end{tabular} \end{table}
PMC2717935_table_3
\begin{table} \centering \label{tab:tablelabel} \begin{tabular}{|l|l|l|l|l|} \hline \textbf{Characteristics} & \textbf{No. of Patients} & \textbf{No. of Deaths} & \textbf{MST (months)} & \textbf{P*} \\ \hline Total subjects Age (mean) & 167 & 60 & & 0.339 \\ \hline 57 years & 68 & 27 & 21.2 \\ \hline >57 years & 99 & 33 & 31.0 \\ \hline Gender & & & & 0.988 \\ \hline Male & 114 & 41 & 23.3 \\ \hline Female & 53 & 19 & 28.9 \\ \hline Ethnicity & & & & 0.297 \\ \hline White & 117 & 45 & 28.8 \\ \hline Non-White† & 50 & 15 & 19.1 \\ \hline Smoke & & & & 0.475 \\ \hline Never & 34 & 14 & 20.6 \\ \hline Ever & 133 & 46 & 30.1 \\ \hline Alcohol & & & & 0.809 \\ \hline Never & 62 & 23 & 23.2 \\ \hline Ever & 105 & 37 & 29.3 \\ \hline Location & & & & 0.069 \\ \hline Stomach & 118 & 36 & 24.3 \\ \hline Esophagus & 25 & 13 & 27.2 \\ \hline GEJ & 24 & 11 & 16.6 \\ \hline Histology & & & & 0.356 \\ \hline Intestinal & 118 & 45 & 28.1 \\ \hline Signet ring & 49 & 15 & 24.6 \\ \hline Differentiation & & & & 0.694 \\ \hline Poor & 96 & 37 & 21.8 \\ \hline Moderate-poor & 28 & 10 & 29.8 \\ \hline Moderate-Well & 42 & 13 & 22.6 \\ \hline Clinical Stage & & & & < 0.001 \\ \hline I + II & 65 & 9 & 30.4 \\ \hline III + IV & 101 & 51 & 22.7 \\ \hline Metastasis & & & & < 0.001 \\ \hline yes & 90 & 49 & 21.2 \\ \hline no & 77 & 11 & 34.2 \\ \hline Chemotherapy & & & & < 0.001 \\ \hline yes & 121 & 54 & 26.3 \\ \hline no & 46 & 6 & 10.4 \\ \hline Surgery & & & & < 0.001 \\ \hline yes & 63 & 11 & 39.2 \\ \hline no & 104 & 49 & 18.4 \\ \hline \end{tabular} \end{table}
PMC2717936_table_0
\begin{table} \centering \label{tab:tablelabel} \begin{tabular}{|l|l|l|} \hline & \textbf{Experimentals (n = 3)} & \textbf{Controls (n = 2)} \\ \hline Brain & 3/3 & 0/2 \\ \hline Spinal cord & 1/3 & 0/1b \\ \hline Adrenal & 0/3 & 0/1b \\ \hline Stomachs & 2/3 & 0/2 \\ \hline Liver & 0/3 & 0/2 \\ \hline Lung & 0/3 & 0/2 \\ \hline Heart & 1/3 & 0/2 \\ \hline Pectoral muscle & 0/3 & 0/2 \\ \hline skin & 0/3 & 0/2 \\ \hline \end{tabular} \end{table}
PMC2717941_table_0
\begin{table} \centering \label{tab:tablelabel} \begin{tabular}{|l|l|l|l|} \hline \textbf{Day} & \textbf{Pattern I} & \textbf{Pattern I}I & \textbf{Total} \\ \hline 7 & 9 (40.9\%) & 13 (59.1\%) & 22 \\ \hline 10 & 7 (29.2\%) & 17 (70.8\%) & 24 \\ \hline 18 & - & 22 (100\%) & 22 \\ \hline \end{tabular} \end{table}
PMC2717942_table_0
\begin{table} \centering \label{tab:tablelabel} \begin{tabular}{|l|l|l|l|} \hline \textbf{Day} & \textbf{Pattern Vpr} & \textbf{Pattern Tat} & \textbf{Total} \\ \hline 3 & 6 (42.8\%) & 8 (57.2\%) & 14 \\ \hline 7 & 9 (52.9\%) & 8 (47.1\%) & 17 \\ \hline 10 & 11 (73.3\%) & 4 (26.7\%) & 15 \\ \hline 18 & 13 (86.7\%) & 2 (13.3\%) & 15 \\ \hline \end{tabular} \end{table}
PMC2717942_table_1
\begin{table} \centering \label{tab:tablelabel} \begin{tabular}{|l|l|l|l|} \hline & \textbf{Number screened} & \textbf{Number positive} & \textbf{Number negative} \\ \hline Males & 97 & 13(13.40\%) & 84(86.59\%) \\ \hline Females & 91 & 14(15.38\%) & 77(84.61\%) \\ \hline Total & 188 & 27(14.36\%) & 161(85.64\%) \\ \hline \end{tabular} \end{table}
PMC2717943_table_0
\begin{table} \centering \label{tab:tablelabel} \begin{tabular}{|l|l|l|l|l|l|} \hline & \multicolumn{5}{c|}{\textbf{AGE GROUP}} \\ \hline & \textbf{18–27} & \textbf{28–37} & \textbf{38–47} & \textbf{48–57} & \textbf{58–67} \\ \hline No. Screened & 44 & 24 & 17 & 10 & 2 \\ \hline Demographics/Socials \\ \hline Married & 4 & 10 & 17 & 10 & 2 \\ \hline Single & 40 & 14 & - & - & - \\ \hline Alcohol Consumption & 21 & 14 & 10 & 4 & 2 \\ \hline Blood Transfusion & 10 & 6 & 3 & 3 & 1 \\ \hline Tattoo/Body Piercing & 6 & 5 & 4 & 3 & 1 \\ \hline Regular Exercise & 26 & 10 & 9 & 4 & 1 \\ \hline HCV Positive & 7 & 1 & 4 & 1 & 0 \\ \hline Percentage Positive & 3.72 & 0.53 & 2.13 & 0.53 & 0 \\ \hline HCV Negative & 37 & 23 & 13 & 9 & 2 \\ \hline Percentage Negative & 19.68 & 12.23 & 6.91 & 4.79 & 1.06 \\ \hline \end{tabular} \end{table}
PMC2717943_table_1
\begin{table} \centering \label{tab:tablelabel} \begin{tabular}{|l|l|l|l|l|l|} \hline & \multicolumn{5}{c|}{\textbf{AGE GROUP}} \\ \hline & \textbf{18–27} & \textbf{28–37} & \textbf{38–47} & \textbf{48–57} & \textbf{58–67} \\ \hline No. Screened & 41 & 35 & 10 & 4 & 1 \\ \hline Demographics/Socials \\ \hline Married & 10 & 27 & 10 & 4 & 1 \\ \hline Single & 31 & 8 & - & - & - \\ \hline Alcohol Intake & 2 & 7 & 3 & 1 & - \\ \hline Blood Transfusion & 11 & 15 & 3 & 2 & - \\ \hline Tattoo/B. Piercing & 35 & 31 & 8 & 4 & 1 \\ \hline Regular Exercise & 21 & 20 & 2 & - & - \\ \hline HCV Positive & 3 & 7 & 3 & 1 & 0 \\ \hline Percentage Positive & 1.60 & 3.72 & 1.60 & 0.53 & 0 \\ \hline HCV Negative & 38 & 28 & 7 & 3 & 1 \\ \hline Percentage Negative & 20.21 & 14.89 & 3.72 & 1.60 & 0.53 \\ \hline \end{tabular} \end{table}
PMC2717943_table_2
\begin{table} \centering \label{tab:tablelabel} \begin{tabular}{|l|l|l|l|} \hline \textbf{VARIABLE} & \textbf{TOTAL NOS(\%)} & \textbf{NOS OF POSITIVE (\%)} & \textbf{P VALUE} \\ \hline Marital status \\ \hline Married & 95 (50.53\%) & 19 (10.11\%) & 0.026 \\ \hline Single & 93 (49.47\%) & 8 (4.26\%) \\ \hline Sex \\ \hline Male & 97 (51.60\%) & 14 (7.45\%) & 0.977 \\ \hline Female & 91 (48.40\%) & 13 (6.91\%) \\ \hline Age \\ \hline 18–27 & 85 (45.21\%) & 10 (5.32\%) & 0.364 \\ \hline 28–37 & 59 (31.38\%) & 8 (4.26\%) \\ \hline 38–47 & 27 (14.36\%) & 7 (3.72\%) \\ \hline 48–57 & 14 (7.45\%) & 2 (1.06\%) \\ \hline 58–67 & 3 (1.60\%) & - (0.00\%) \\ \hline Blood transfusion \\ \hline YES & 54 (28.72\%) & 7 (3.72\%) & 0.728 \\ \hline NO & 134 (71.28\%) & 20 (10.64\%) \\ \hline Tattoo/body piercing \\ \hline YES & 98 (52.13\%) & 12 (6.38\%) & 0.338 \\ \hline NO & 90 (47.87\%) & 15 (7.98\%) \\ \hline Alcohol intake \\ \hline YES & 64 (34.04\%) & 7 (3.72\%) & 0.218 \\ \hline NO & 124 (65.96\%) & 20 (10.64\%) \\ \hline Exercise \\ \hline YES & 92 (48.94\%) & 14 (7.45\%) & 0.743 \\ \hline NO & 96 (51.06\%) & 13 (6.91\%) \\ \hline \end{tabular} \end{table}
PMC2717943_table_3
\begin{table} \centering \label{tab:tablelabel} \begin{tabular}{|l|l|l|l|l|} \hline & \multicolumn{2}{c|}{\textbf{Men}} & \multicolumn{2}{c|}{\textbf{Women}} \\ \hline & \textbf{\textbf{AST (\%)}} & \textbf{\textbf{ALT (\%)}} & \textbf{\textbf{AST (\%)}} & \textbf{\textbf{ALT (\%)}} \\ \hline Nos showing normal level & 12(12.37) & 10(10.31) & 10(10.99) & 9(9.89) \\ \hline Nos showing abnormal level & 2(2.06) & 4(4.12) & 3(3.29) & 3(3.29) \\ \hline \end{tabular} \end{table}
PMC2717943_table_4
\begin{table} \centering \label{tab:tablelabel} \begin{tabular}{|l|l|} \hline \textbf{Quality Statistic1} & \textbf{Description} \\ \hline mean.raw.int, sd.raw.int, median.raw.int, interQuartile.raw.int & mean, standard deviation, median and inter-quartile range of raw log intensity distribution. \\ \hline q.5.raw.int, q.95.raw.int & 5th and 95th percentile of raw log intensity distribution. \\ \hline slope.bias, p.bias & slope parameter and associated p-value of linear regression of log expression level versus probe number, as computed by R affy library function AffyRNAdeg(). \\ \hline mean.norm.int, sd.norm.int, median.norm.int, interQuartile.norm.int, q.5.norm.int, q.95.norm.int & mean, standard deviation, median, inter-quartile range, and 5th and 95th percentiles of normalized log intensity distribution. \\ \hline PLM.w.q.0.001, PLM.w.q.0.01, PLM.w.q.0.1, PLM.w.q.0.2 & 0.1th, 1st, 10th and 20th percentile of the probe-level model weights, computed using affyPLM library functionality. \\ \hline PLM.res.q.0.01, PLM.res.q.0.1, PLM.res.q.0.25, PLM.res.q.0.75, PLM.res.q.0.9, PLM.res.q.0.99 & 1st, 10th, 25th, 75th, 90th, and 99th percentile of probe-level model residuals, computed using affyPLM library functionality. \\ \hline RLE.median, RLE.interQuartile, RLE.lower.whisker, RLE.upper.whisker & median, inter-quartile range, lower tail and upper tail of "relative log intensity", computed using affyPLM library functionality. \\ \hline \end{tabular} \end{table}
PMC2717951_table_0
\begin{table} \centering \label{tab:tablelabel} \begin{tabular}{|l|l|} \hline \textbf{Quality Statistic1} & \textbf{Description} \\ \hline pm.mean & mean of the raw intensity for all PM probes, prior to any normalizations. \\ \hline bgrd.mean & mean of the raw intensity for all probes used to compute background intensity. (Note: may be higher than pm.mean because GC compositions of probes used to compute background and PM probes can be quite different.) \\ \hline pos.vs.neg.auc & area under ROC curve discriminating between positive control probesets and negative control probesets. \\ \hline probeset.mean, probeset.stdev & mean and standard deviation of probeset signals after normalization. 2 \\ \hline probeset.mad.residual.mean, probeset.mad.residual.stdev & mean and standard deviation of the absolute deviations of the RMA probe level model residuals from the median across chips. 2 \\ \hline probeset.rle.mean, probeset.rle.stdev & mean and standard deviation of the absolute values of the relative log expression (RLE) for all probesets. 2 \\ \hline \end{tabular} \end{table}
PMC2717951_table_1
\begin{table} \centering \label{tab:tablelabel} \begin{tabular}{|l|l|l|} \hline \multicolumn{3}{c|}{\textbf{\% Example of the DOTcvp simple input file for the drug displacement problem}} \\ \hline \textbf{data.name} & \textbf{= 'DrugDisplacement';} & \textbf{\% name of the problem} \\ \hline \textbf{data.odes.parameters(1)} & \textbf{= {'A = 232'};} & \textbf{\% constant parameters before ODE} \\ \hline data.odes.parameters(2) & = {'B = 46.4'}; \\ \hline data.odes.parameters(3) & = {'C = 2152.96'}; \\ \hline data.odes.res(1) & \multicolumn{2}{c|}{= {'((1+0.2*(y(1)+y(2)))^2/(((1+0.2*(y(1)+y(2)))^2+A+B*y(2))*((1+0.2*(y(1)+y(2)))^2+A+B*y(1))- C*y(1)*y(2)))*(((1+0.2*(y(1)+y(2)))^2+A+B*y(1))*(0.02-y(1))+B*y(1)*(u(1)-2*y(2)))'};} \\ \hline data.odes.res(2) & \multicolumn{2}{c|}{= {'((1+0.2*(y(1)+y(2)))^2/(((1+0.2*(y(1)+y(2)))^2+A+B*y(2))*((1+0.2*(y(1)+y(2)))^2+A+B*y(1))- C*y(1)*y(2)))*(((1+0.2*(y(1)+y(2)))^2+A+B*y(2))*(u(1)-2*y(2))+46.4*(0.02-y(1)))'};} \\ \hline data.odes.res(3) & = {'1'}; \\ \hline data.odes.ic & = [0.02 0.0 0.0]; & \% vector of initial conditions \\ \hline data.odes.tf & = 300.0; & \% final time \\ \hline data.nlp.RHO & = 5; & \% CVP discretization level \\ \hline data.nlp.J0 & = 'y(3)'; & \% performance index, min-max(performance index) \\ \hline data.nlp.u0 & = 4.0; & \% initial guess for control values \\ \hline data.nlp.lb & = 0.0; & \% lower bounds for control values \\ \hline data.nlp.ub & = 8.0; & \% upper bounds for control values \\ \hline data.nlp.solver & = 'IPOPT'; & \% ['FMINCON'|'IPOPT'|'SRES'|'DE'|'ACOMI'|'MISQP'|'MITS'] \\ \hline data.nlp.FreeTime & = 'on'; & \% ['on'|'off'] set 'on' if free time is considered \\ \hline data.nlp.eq.status & = 'on'; & \% ['on'|'off'] switch on/off of the equality constraints \\ \hline data.nlp.eq.NEC & = 2; & \% number of active equality constraints \\ \hline data.nlp.eq.eq(1) & = {'y(1)-0.02'}; & \% first equality constraint \\ \hline data.nlp.eq.eq(2) & = {'y(2)-2.0'}; & \% second equality constraint \\ \hline data.nlp.eq.time(1) & = data.nlp.RHO; & \% to indicate that it is an end-point constraint \\ \hline data.nlp.eq.time(2) & = data.nlp.RHO; & \% to indicate that it is an end-point constraint \\ \hline data.options.trajectories & = size(data.odes.res,2)-1; & \% how many state trajectories will be displayed \\ \hline \end{tabular} \end{table}
PMC2717952_table_0
\begin{table} \centering \label{tab:tablelabel} \begin{tabular}{|l|l|l|l|l|} \hline & \multicolumn{2}{c|}{\textbf{Men}} & \multicolumn{2}{c|}{\textbf{Women}} \\ \hline & \textbf{\textbf{General Workforce}/1} & \textbf{\textbf{Index Group}} & \textbf{General Workforce} & \textbf{\textbf{Index Group}} \\ \hline Number & 1691 & 41 & 794 & 56 \\ \hline Age in years/2 & 38.5 & 38.4 & 40.6 & 40.5 \\ \hline Years of Work Experience/2 & 9.8 & 9.0 & 10.5 & 9.9 \\ \hline CD4 count for initiating ART \\ \hline Mean & & 144 & & 183 \\ \hline Median & & 145 & & 187 \\ \hline IQR & & 68–224 & & 105–270 \\ \hline \end{tabular} \end{table}
PMC2717954_table_0
\begin{table} \centering \label{tab:tablelabel} \begin{tabular}{|l|l|l|} \hline \textbf{Organizational model} & \textbf{Definition} & \textbf{Example} \\ \hline Small family doctor based models (registration at a & family doctor practice) \\ \hline Individual general family practice & The GP takes care of his own patients 24 hours a day, 7 days a week. & Rural areas of Austria \\ \hline Rota groups (rota) & GPs who are active in the same region take turns being on duty out-of-hours for the patient population of all (up to 15) members of the rota group & Municipalities in Norway \\ \hline Large family doctor based models (independent of & registration at a family doctor practice) \\ \hline GP cooperatives & GPs work in a non-profit organization and take turns being on duty out-of-hours for the patient population of all participating GPs. These are large-scale organizations that are supported by nurses, management, chauffeurs, et cetera. & Mostly used model for out-of-hours primary care in the Netherlands \\ \hline Primary care centers (PCC) & Centers, which patients can visit without an appointment for minor injuries or illnesses. Such centers operate under supervision of a general practitioner or family physician. & In Slovenia one PCC (of all daytime centers) functions as out-of-hours center \\ \hline Deputizing services & Commercial agencies that employ GPs to take over duties of other GPs. & NHS direct is common in the United Kingdom \\ \hline Minor injury centers or walk-in-centers & Centers, which patients can visit without an appointment for minor injuries or illnesses in order to ask a trained nurse for health information, advice and treatment. & Ireland has a few privately organized models \\ \hline Hospital based and national models \\ \hline Telephone triage and advice services (TTA) & Patients have contact with a medically trained professional via a fixed, non-regional, telephone number. This person advises or refers the patient to the most suitable professional. & National call center in Portugal \\ \hline Emergency departments of hospitals (A&E) & Emergency departments of hospitals taking care of patients out-of-hours. & Unofficially used by patients in Belgium \\ \hline Primary out-of-hours care integrated in the hospital & Primary out-of-hours care integrated in the hospital (for example, in emergency departments). & Some experiments in Italy \\ \hline \end{tabular} \end{table}
PMC2717955_table_0
\begin{table} \centering \label{tab:tablelabel} \begin{tabular}{|l|l|} \hline \textbf{Country} & \textbf{#} \\ \hline Australia & 2 \\ \hline Austria & 3 \\ \hline Belgium & 7 \\ \hline Canada & 2 \\ \hline Croatia & 1 \\ \hline Czech Republic & 2 \\ \hline Denmark & 1 \\ \hline France & 3 \\ \hline Germany & 1 \\ \hline Greece & 5 \\ \hline Iceland & 2 \\ \hline Ireland & 1 \\ \hline Israel & 1 \\ \hline Italy & 4 \\ \hline The Netherlands & 2 \\ \hline New Zealand & 2 \\ \hline Norway & 6 \\ \hline Poland & 3 \\ \hline Portugal & 1 \\ \hline Slovenia & 6 \\ \hline Spain & 1 \\ \hline Sweden & 5 \\ \hline Switzerland & 4 \\ \hline United Kingdom & 4 \\ \hline United States of America & 2 \\ \hline Total & 71 \\ \hline \end{tabular} \end{table}
PMC2717955_table_1
\begin{table} \centering \label{tab:tablelabel} \begin{tabular}{|l|l|l|l|l|} \hline \textbf{Country} & \textbf{Respondents (N)} & \textbf{Models (N)} & \textbf{Dominant model*} & \textbf{Planned changes} \\ \hline Croatia & 1 & 3 & Emergency department & - \\ \hline Czech Republic & 2 & 3 & Primary care integrated in hospital & Upscale care, patient fee, integrate GP coop and A&E department \\ \hline Denmark & 1 & 4 & Telephone triage and advice service & Upscale care \\ \hline Israel & 1 & 4 & Emergency department & - \\ \hline Portugal & 1 & 4 & Primary care center & - \\ \hline The Netherlands & 2 & 4 & GP cooperative & Upscale care, integrate CP coop and A&E department \\ \hline Germany & 1 & 5 & Rota group & - \\ \hline Iceland & 2 & 5 & Primary care center GP cooperative & - \\ \hline Slovenia & 6 & 6 & Rota group & Change organization, upscale care \\ \hline Spain & 1 & 6 & Telephone triage and advice service & Upscale care \\ \hline Austria & 3 & 7 & Rota group & Upscale care, change structure \\ \hline Greece & 5 & 7 & Individual general family practice & Upscale care, change organization \\ \hline Poland & 3 & 7 & - & Change organization \\ \hline France & 3 & 8 & Emergency department Rota group & Upscale care \\ \hline Sweden & 5 & 8 & GP cooperative & Centralization of out-of-hours calls and triage, change organization \\ \hline Switzerland & 4 & 8 & Rota group & Upscale care, call center service \\ \hline Belgium & 7 & 9 & Rota group & Upscale care, centralization of out-of-hours calls and triage \\ \hline Canada & 2 & 9 & Emergency department & Upscale care \\ \hline Italy & 4 & 9 & Other (Guardia Medica) & Upscale care \\ \hline New Zealand & 2 & 9 & GP cooperative Rota group & - \\ \hline Australia & 2 & 10 & Individual general family practice GP cooperative & Improve access to high quality health care services \\ \hline Ireland & 1 & 10 & GP cooperative & Upscale care \\ \hline Norway & 6 & 10 & Rota group & Upscale care, enhance uniformity \\ \hline United Kingdom & 4 & 10 & Deputizing service & - \\ \hline United States of America & 2 & 10 & Rota group & Many different approaches \\ \hline \end{tabular} \end{table}
PMC2717955_table_2
\begin{table} \centering \label{tab:tablelabel} \begin{tabular}{|l|l|l|l|l|l|l|l|l|} \hline & \multicolumn{2}{c|}{\textbf{Small family doctor based models}} & \multicolumn{3}{c|}{\textbf{Large family doctor based models}} & \multicolumn{3}{c|}{\textbf{Hospital based and national models}} \\ \hline & \textbf{Individual general family practice (N = 3)} & \textbf{Rota group (N = 21)} & \textbf{GP coopera- tive (N = 9)} & \textbf{Primary care center (N = 5)} & \textbf{Deputizing service (N = 3)} & \textbf{A&E department (N = 7)} & \textbf{Telephone triage and advice (N = 3)} & \textbf{Integrated care (N = 1)} \\ \hline Continuity of care & - & 0 & 0 & - & - & - & - & + \\ \hline Efficiency & 0 & 0 & + & - & - & - & 0 & + \\ \hline Accessibility & + & + & + & + & 0 & - & + & 0 \\ \hline Coordination of care & 0 & 0 & + & - & - & - & 0 & + \\ \hline Satisfaction physicians & 0 & - & + & - & 0 & 0 & - & 0 \\ \hline Satisfaction other professionals & 0 & 0 & + & 0 & + & 0 & - & 0 \\ \hline Satisfaction patients & 0 & + & + & 0 & 0 & + & + & - \\ \hline Safety of triage & 0 & + & + & 0 & 0 & 0 & 0 & + \\ \hline \end{tabular} \end{table}
PMC2717955_table_3
\begin{table} \centering \label{tab:tablelabel} \begin{tabular}{|l|l|l|} \hline \textbf{Trial characteristic} & & \textbf{Number of Included RCT Reports (\%)} \\ \hline \multirow{6}{*}{Journal} & NEJM & 39 (29.3) \\ \hline Lancet & 31 (23.3) \\ \hline JAMA & 25 (18.8) \\ \hline BMJ & 15 (11.3) \\ \hline Annals of Internal Medicine & 13 (9.8) \\ \hline Annals of Surgery & 10 (7.5) \\ \hline \multirow{4}{*}{Sample Size} & <200 & 33 (24.8) \\ \hline 200–449 & 37 (27.8) \\ \hline 450–749 & 31 (23.3) \\ \hline 750+ & 32 (24.1) \\ \hline \multirow{2}{*}{Centres} & Multiple & 95 (71.4) \\ \hline Single & 38 (28.6) \\ \hline \multirow{3}{*}{Study Design} & Parallel & 125 (94.0) \\ \hline Factorial & 5 (3.8) \\ \hline Crossover & 3 (2.3) \\ \hline \multirow{5}{*}{Number of Arms} & Two & 103 (77.4) \\ \hline Three & 14 (10.5) \\ \hline Four & 12 (9.0) \\ \hline Five & 2 (1.5) \\ \hline Six & 2 (1.5) \\ \hline \multirow{4}{*}{Interventions} & Drug & 68 (51.1) \\ \hline Surgery & 21 (15.8) \\ \hline Allied/Complementary Medicine & 20 (15.0) \\ \hline Othera & 24 (18.1) \\ \hline \multirow{2}{*}{Nature of Control Arm} & Active Control & 63 (47.4) \\ \hline Placebo Control & 70 (52.6) \\ \hline \multirow{2}{*}{Funding Source} & Externalb & 123 (92.5) \\ \hline Internal/Not statedc & 10 (7.5) \\ \hline \end{tabular} \end{table}
PMC2717957_table_0
\begin{table} \centering \label{tab:tablelabel} \begin{tabular}{|l|l|l|l|} \hline \textbf{Journal} & \textbf{Yes completely (\%)} & \textbf{Yes partially (\%)} & \textbf{No (\%)} \\ \hline JAMA (n = 25) & 20 (80.0) & 5 (20.0) & 0 \\ \hline Annals Int. Med. (n = 13) & 10 (76.9) & 2 (15.4) & 1 (7.7) \\ \hline BMJ (n = 15) & 10 (66.7) & 5 (33.3) & 0 \\ \hline Lancet (n = 31) & 16 (51.6) & 15 (48.4) & 0 \\ \hline NEJM (n = 39) & 7 (17.9) & 10 (25.6) & 22 (56.4) \\ \hline Annals Surgery (n = 10) & 1 (10.0) & 4 (40.0) & 5 (50.0) \\ \hline Total (n = 133) & 64 (48.1) & 41 (30.8) & 28 (21.1) \\ \hline \end{tabular} \end{table}
PMC2717957_table_1
\begin{table} \centering \label{tab:tablelabel} \begin{tabular}{|l|l|l|l|l|l|} \hline \textbf{Current stagea} & \textbf{Next stagea} & \textbf{Number of studiesb} & \textbf{Median progressing to next stage} & \textbf{First and third quartiles} & \textbf{Minimum and maximum} \\ \hline Invited to eligibility assessment & Attended eligibility assessment & 13 & 70\% & 44\%, 96\% & 15\%, 100\% \\ \hline Attended eligibility assessment & Found to be eligible & 71 & 70\% & 49\%, 88\% & 6\%, 100\% \\ \hline Found to be eligible & Randomised to a treatment arm & 75 & 90\% & 77\%, 100\% & 20\%, 100\% \\ \hline Randomised to a treatment arm & Outcome assessed & 113 & 93\% & 86\%, 99\% & 49\%, 100\% \\ \hline Outcome assessed & Included in analysis & 111 & 100\% & 100\%, 103\%c & 100\%, 202\%c \\ \hline \end{tabular} \end{table}
PMC2717957_table_2
\begin{table} \centering \label{tab:tablelabel} \begin{tabular}{|l|l|l|l|l|} \hline & \textbf{Number of studiesa} & \textbf{Median \% of sample size required} & \textbf{First and third quartiles} & \textbf{Minimum and maximum} \\ \hline Invited to screening & 12 & 410\% & 288\%, 951\% & 131\%, 2549\% \\ \hline Attend screening & 62 & 230\% & 132\%, 379\% & 83\%, 2361\% \\ \hline Eligible & 58 & 130\% & 108\%, 160\% & 72\%, 431\% \\ \hline Randomised & 106 & 110\% & 100\%, 128\% & 43\%, 213\% \\ \hline Outcome assessed & 94 & 100\% & 92\%, 111\% & 36\%, 158\% \\ \hline In analysis & 102 & 103\% & 98\%, 117\% & 43\%, 169\% \\ \hline \end{tabular} \end{table}
PMC2717957_table_3
\begin{table} \centering \label{tab:tablelabel} \begin{tabular}{|l|l|l|l|l|l|l|l|l|l|} \hline & \multicolumn{3}{c|}{\textbf{Screened and eligible}} & \multicolumn{3}{c|}{\textbf{Eligible and randomised}} & \multicolumn{3}{c|}{\textbf{Randomised and outcome assessed}} \\ \hline \textbf{Factor & level} & \textbf{\textbf{\textbf{Median}}} & \textbf{\textbf{\textbf{IQR}}} & \textbf{\textbf{\textbf{Number of studies}}} & \textbf{\textbf{\textbf{Median}}} & \textbf{\textbf{\textbf{IQR}}} & \textbf{\textbf{\textbf{Number of studies}}} & \textbf{\textbf{\textbf{Median}}} & \textbf{\textbf{\textbf{IQR}}} & \textbf{\textbf{\textbf{Number of studies}}} \\ \hline Study size \\ \hline <200 & 78 & 63, 95 & 25 & 90 & 79, 100 & 26 & 92 & 86, 94 & 32 \\ \hline 200–449 & 71 & 56, 95 & 18 & 93 & 78, 99 & 21 & 92 & 86, 99 & 29 \\ \hline 450–749 & 51 & 33, 64 & 15 & 86 & 66, 97 & 15 & 93 & 84, 98 & 23 \\ \hline \multirow{2}{*}{750+} & 71 & 41, 80 & 13 & 91 & 85, 100 & 13 & 97 & 89, 100 & 29 \\ \hline & & p = 0.026 & & & p = 0.99 & & & p = 0.24 \\ \hline Number of arms \\ \hline 2 & 72 & 48, 93 & 56 & 90 & 78, 100 & 59 & 94 & 88, 99 & 89 \\ \hline \multirow{2}{*}{3+} & 68 & 51, 79 & 15 & 89 & 70, 97 & 16 & 86 & 76, 94 & 24 \\ \hline & & p = 0.33 & & & p = 0.75 & & & p = 0.0035 \\ \hline Multi-centre? \\ \hline Yes & 75 & 42, 86 & 44 & 92 & 73, 99 & 47 & 94 & 85, 99 & 79 \\ \hline \multirow{2}{*}{No} & 64 & 50, 94 & 27 & 87 & 78, 100 & 28 & 93 & 88, 96 & 34 \\ \hline & & p = 0.91 & & & p = 0.70 & & & p = 0.64 \\ \hline Treatment focus \\ \hline Drug & 71 & 53, 86 & 29 & 94 & 73, 100 & 30 & 94 & 86, 99 & 56 \\ \hline Surgery & 75 & 48, 99 & 10 & 89 & 63, 100 & 10 & 99 & 92, 100 & 17 \\ \hline Allied & 67 & 50, 88 & 17 & 91 & 81, 99 & 18 & 90 & 85, 94 & 18 \\ \hline \multirow{2}{*}{Other} & 64 & 44, 86 & 15 & 86 & 79, 93 & 17 & 92 & 84, 96 & 22 \\ \hline & & p = 0.89 & & & p = 0.56 & & & p = 0.014 \\ \hline Control \\ \hline Active & 70 & 51, 86 & 30 & 88 & 74, 95 & 32 & 92 & 85, 98 & 52 \\ \hline \multirow{2}{*}{Placebo} & 68 & 49, 88 & 41 & 94 & 77, 100 & 43 & 93 & 86, 99 & 61 \\ \hline & & p = 0.82 & & & p = 0.24 & & & p = 0.46 \\ \hline Time to assessment \\ \hline 0 to 4 weeks & 8 & 33, 86 & 10 & 83 & 63, 94 & 11 & 99 & 93, 100 & 26 \\ \hline >4 weeks to 6 months & 7 & 51, 78 & 23 & 91 & 81, 100 & 24 & 92 & 87, 94 & 30 \\ \hline >6 to 18 months & 74 & 40, 93 & 20 & 94 & 72, 99 & 21 & 88 & 79, 98 & 31 \\ \hline \multirow{2}{*}{>18 months} & 75 & 63, 93 & 16 & 91 & 83, 100 & 16 & 95 & 86, 100 & 23 \\ \hline & & p = 0.087 & & & p = 0.242 & & & p = 0.075 \\ \hline Funding \\ \hline Pharma & 74 & 54, 93 & 28 & 94 & 83, 100 & 29 & 93 & 85, 99 & 56 \\ \hline Government/charity & 67 & 48, 86 & 38 & 85 & 70, 97 & 40 & 93 & 86, 96 & 49 \\ \hline \multirow{2}{*}{Internal/unstated} & 56 & 51, 56 & 5 & 98 & 94, 100 & 6 & 95 & 91, 100 & 8 \\ \hline & & p = 0.51 & & & p = 0.048 & & & P = 0.50 \\ \hline \end{tabular} \end{table}
PMC2717957_table_4
\begin{table} \centering \label{tab:tablelabel} \begin{tabular}{|l|l|l|} \hline \textbf{Total number of patients} & & \textbf{47} \\ \hline Male & & 24 \\ \hline Female & & 23 \\ \hline Age at start of ART (months) & Median (range) & 98 (8–151) \\ \hline \multirow{2}{*}{WHO stage} & II & 22 \\ \hline III & 25 \\ \hline \multirow{4}{*}{Immunological stage} & I & 1 \\ \hline II & 8 \\ \hline III & 36 \\ \hline Not classified & 2 \\ \hline \end{tabular} \end{table}
PMC2717958_table_0
\begin{table} \centering \label{tab:tablelabel} \begin{tabular}{|l|l|} \hline \textbf{Total no. of visits with appointments given (\%)} & \textbf{401 (100)} \\ \hline As scheduled & 206 (51) \\ \hline Before appointment & 58 (15) \\ \hline Within 1 week after appointment & 63 (16) \\ \hline More than 1 week after appointment & 74 (18) \\ \hline \end{tabular} \end{table}
PMC2717958_table_1
\begin{table} \centering \label{tab:tablelabel} \begin{tabular}{|l|l|} \hline \textbf{Demographics} & \textbf{N = 395*} \\ \hline Gender (\% females) & 28.9\% \\ \hline Age, years; mean (SD) & 39.1 (8.2) \\ \hline Age at onset of disease, years; mean (SD) & 23.1 (7.1) \\ \hline Severity of Psychopathology \\ \hline Previous number of episodes; mean (SD) & 6.65 (8.3) \\ \hline PANSS overall score; mean (SD) & 2.76 (0.46) \\ \hline PANSS negative; mean (SD) & 2.83 (0.81) \\ \hline PANSS positive; mean (SD) & 3.18 (0.66) \\ \hline Quality of Life Functional Domains \\ \hline QLS Instrumental Role Functioning; mean (SD) & 3.35 (0.90) \\ \hline QLS Interpersonal Relations; mean (SD) & 2.57 (1.16) \\ \hline QLS Intrapsychic Foundation; mean (SD) & 2.99 (1.13) \\ \hline Cognitive Subdomains (z scores against healthy controls) \\ \hline Working Memory; mean (SD) & -1.01 (1.12) \\ \hline Verbal Memory; mean (SD) & -1.41 (1.3) \\ \hline Processing Speed; mean (SD) & -1.12 (0.80) \\ \hline \end{tabular} \end{table}
PMC2717959_table_0
\begin{table} \centering \label{tab:tablelabel} \begin{tabular}{|l|l|l|l|l|l|l|l|l|} \hline & \textbf{QLS Intrapsychic} & \textbf{QLS Intpersonal} & \textbf{Processing Speed} & \textbf{Working Memory} & \textbf{Verbal Memory} & \textbf{Neg} & \textbf{Pos} & \textbf{PANSS Overall} \\ \hline QLS Instrumental & 0.58*** & 0.47*** & 0.15** & 0.13** & 0.16** & -0.23*** & -0.22*** & -0.32*** \\ \hline \textbf{QLS Intrapsychic} & & 0.64*** & 0.21*** & 0.16** & 0.15** & -0.48*** & -0.26*** & -0.47*** \\ \hline QLS Interpersonal & & & 0.15** & 0.02 & 0.02 & -0.38*** & -0.26*** & -0.37*** \\ \hline \textbf{Processing Speed} & & & & 0.55*** & 0.53*** & -0.16** & -0.03 & -0.08 \\ \hline \textbf{Working Memory} & & & & & 0.48*** & -0.02 & -0.09 & -0.10 \\ \hline \textbf{Verbal Memory} & & & & & & -0.07 & -0.02 & -0.11* \\ \hline PANSS \textbf{Neg} & & & & & & & 0.13* & 0.61*** \\ \hline PANSS \textbf{Pos} & & & & & & & & 0.72*** \\ \hline \end{tabular} \end{table}
PMC2717959_table_1
\begin{table} \centering \label{tab:tablelabel} \begin{tabular}{|l|l|l|l|l|l|l|l|l|} \hline & \textbf{QLS Intrapsychic} & \textbf{QLS Interpersonal} & \textbf{Processing Speed} & \textbf{Working Memory} & \textbf{Verbal Memory} & \textbf{Neg} & \textbf{Pos} & \textbf{PANSS Overall} \\ \hline QLS Instrumental & 0.33*** & 0.23*** & 0.17* & 0.06 & 0.03 & -0.16* & -0.07 & -0.14* \\ \hline \textbf{QLS Intrapsychic} & & 0.46*** & 0.22** & 0.11 & 0.06 & -0.38*** & -0.02 & -0.17* \\ \hline \textbf{QLS Interpersonal} & & & 0.04 & -0.11 & -0.01 & -0.17* & -0.09 & -0.16* \\ \hline \textbf{Processing Speed} & & & & 0.29*** & 0.25*** & -0.17* & 0.06 & -0.05 \\ \hline \textbf{Working Memory} & & & & & 0.08 & 0.04 & -0.02 & 0.04 \\ \hline \textbf{Verbal Memory} & & & & & & -0.15* & 0.12 & -0.05 \\ \hline PANSS \textbf{Neg} & & & & & & & 0.12 & 0.60*** \\ \hline PANSS \textbf{Pos} & & & & & & & & 0.75*** \\ \hline \end{tabular} \end{table}
PMC2717959_table_2
\begin{table} \centering \label{tab:tablelabel} \begin{tabular}{|l|l|l|l|l|l|l|l|l|} \hline & \textbf{Sample Size} & \textbf{Age (years)} & \textbf{Follow-up (months)} & \textbf{Baseline GFR (ml/min/1.73 m2) (inulin clearance)} & \textbf{Baseline creatinine (μmol/L)} & \textbf{Number of GFR measurements} & \textbf{Final GFR (ml/min/1.73 m2) (inulin clearance)} & \textbf{Final Creatinine (μmol/L)} \\ \hline Whole group & 126 & 40.36 $\pm$ 12.48 [17–69] & 37.56 $\pm$ 27.04 [6–117] & 71.03 $\pm$ 24.02 [20–138] & 119.03 $\pm$ 50.85 [49–319] & 3.43 $\pm$ 2.06 [2–11] & 71.19 $\pm$ 26.93 [18–140] & 123.24 $\pm$ 69.195 [53–485] \\ \hline Patients with deterioration in renal function & 65 & 39.15 $\pm$ 12.50 [20–65] & 42.86 $\pm$ 29.47 [6–117] & 75.30 $\pm$ 26.15 [20–138] & 123.15 $\pm$ 57.85 [49–316] & 3.72 $\pm$ 2.2 [2–11] & 61.67 $\pm$ 25.49 [18–118] & 141.81 $\pm$ 85.97 [63–485] \\ \hline Patients with improvement in renal function & 61 & 41.65 $\pm$ 12.43 [17–69] & 31.91 $\pm$ 23.11 [6–93] & 66.47 $\pm$ 20.78 [24–124] & 114.81 $\pm$ 42.21 [53–285] & 3.13 $\pm$ 1.8 [2–10] & 81.32 $\pm$ 24.79 [25–140] & 103.45 $\pm$ 36.31 [53–247] \\ \hline \end{tabular} \end{table}
PMC2717960_table_0
\begin{table} \centering \label{tab:tablelabel} \begin{tabular}{|l|l|l|l|} \hline & \textbf{Accuracy 10\% (95\% CI)} & \textbf{Accuracy 30\% (95\% CI)} & \textbf{Accuracy 50\% (95\% CI)} \\ \hline Cockcroft-Gault formula & 43.6\% [35\% – 52\%] & 41.3\% [33\% – 50\%] & 15\% [9\% – 22\%] \\ \hline BSA-Cockcroft Gault formula & 53.2\% [44\% – 61\%] & 39.6\% [31\% – 48\%] & 7.1\% [3.6\% – 13\%] \\ \hline Abbreviated MDRD equation & 37.3\% [29\% – 46\%] & 52.4\% [43\% – 60\%] & 10.3\% [6\% – 16,9\%] \\ \hline Mayo Clinic Quadratic equation & 27.7\% [20\% – 36\%] & 39.7\% [31\% – 48\%] & 32.6\% [24\% – 41\%] \\ \hline \end{tabular} \end{table}
PMC2717960_table_1
\begin{table} \centering \label{tab:tablelabel} \begin{tabular}{|l|l|l|l|l|} \hline & \textbf{Method of GFR estimation} & \textbf{Slope of GFR (ml/min/1.73 m2/year) Median and [range]} & \textbf{p value in the Friedman test (non parametric ANOVA)} & \textbf{P value in Dunn's multiple comparison post-test} \\ \hline \multirow{5}{*}{Subgroup of patients with deteriorating renal function (n = 65)} & Inulin Clearance & -3.72 [-0.48 to -72] \\ \hline GFR Cockcroft-Gault & -4.08 [-0.36 to -60] & & NS \\ \hline BSA-modified Cockcroft- Gault Formula & -3.48 [-0.24 to -56] & p = 0.29 & NS \\ \hline Abbreviated MDRD equation & -3.12 [0 to -64] & & NS \\ \hline Mayo Clinic Quadratic equation & -3.73 [0 to -78] & & NS \\ \hline \multirow{5}{*}{Subgroup of patients with improving renal function (n = 61)} & Inulin Clearance & +6 [+0.36 to +99] \\ \hline GFR Cockcroft-Gault & +4.2 [0 to +102] & p < 0.001 & p < 0.05 \\ \hline BSA-modified Cockcroft- Gault Formula & +3.36 [+0.12 to +109] & & p < 0.05 \\ \hline Abbreviated MDRD equation & +5.04 [0 to +138] & & p < 0.05 \\ \hline Mayo Clinic Quadratic equation & +4.74 [0 to +53] & & p < 0.05 \\ \hline \end{tabular} \end{table}
PMC2717960_table_2
\begin{table} \centering \label{tab:tablelabel} \begin{tabular}{|l|l|l|l|l|l|} \hline & & \textbf{Original Cockcroft and Gault formula (CG)} & \textbf{BSA-modified- Cockcroft and Gault formula (BSA-CG)} & \textbf{Abbreviated MDRD equation (A-MDRD)} & \textbf{Mayo Clinic Quadratic equation (MCQ)} \\ \hline \multirow{3}{*}{Subgroup of patients with deteriorating renal function (n = 65)} & Spearman Correlation coefficient (95\% confidence interval) with inulin clearance & r = 0.64 (0.43 – 0.78) & r = 0.67 (0.46 – 0.80) & r = 0.63 (0.41 – 0.78) & r = 0.49 (0.23 – 0.69) \\ \hline Patients correctly classified as having deteriorating renal function & 74\% & 77\% & 75\% & 74\% \\ \hline Bias (SD of bias) versus inulin clearance & 0.98 (6.08) & 1.37 (6.88) & 1.30 (5.95) & 1.32 (13.61) \\ \hline \multirow{3}{*}{Subgroup of patients with improving renal function (n = 61)} & Spearman Correlation coefficient (95\% confidence interval) inulin clearance & 0.75 (0.58 – 0.86) & r = 0.75 (0.58 – 0.86) & r = 0.72 (0.54 – 0.84) & r = 0.46 (0.19 – 0.67) \\ \hline Patients correctly classified as having improving renal function & 74\% & 74\% & 66\% & 68\% \\ \hline Bias (SD of bias) versus inulin clearance & 3.08 (7.98) & 2.98 (7.63) & 1.27 (8.87) & 3.02 (15.46) \\ \hline \end{tabular} \end{table}
PMC2717960_table_3
\begin{table} \centering \label{tab:tablelabel} \begin{tabular}{|l|l|l|l|l|} \hline \textbf{Cell population} & \multicolumn{2}{c|}{\textbf{ANTEROGRADE EVENTS (μm/sec Mean Velocity $\pm$ SE)}} & \multicolumn{2}{c|}{\textbf{RETROGRADE EVENTS (μm/sec Mean Velocity $\pm$ SE)}} \\ \hline \textbf{Hippocampal neurons} & \textbf{\textbf{Axons}} & \textbf{\textbf{Dendrites}} & \textbf{\textbf{Axons}} & \textbf{\textbf{Dendrites}} \\ \hline 1–2 DIV & 0.23 $\pm$ 0.02 (142) & 0.25 $\pm$ 0.02 (114) & 0.29 $\pm$ 0.05 (22) & 0.20 $\pm$ 0.05 (9) \\ \hline 3–4 DIV & 0.26 $\pm$ 0.01 (214) & 0.36 $\pm$ 0.02 (199) & 0.43 $\pm$ 0.20 (5) & 0.27 $\pm$ 0.03 (44) \\ \hline > 7 DIV & 0.33 $\pm$ 0.02 (86) & 0.22 $\pm$ 0.03 (68) & 0.35 (1) & 0.18 $\pm$ 0.03 (21) \\ \hline PC12 Cells & \multicolumn{2}{c|}{0.18 $\pm$ 0.003 (382)} & \multicolumn{2}{c|}{0.17 $\pm$ 0.01 (86)} \\ \hline \end{tabular} \end{table}
PMC2717962_table_0
\begin{table} \centering \label{tab:tablelabel} \begin{tabular}{|l|l|l|l|} \hline \textbf{Socioeconomic characteristic} & \textbf{– The least poor 'Abagaiga'} & \textbf{– 'Abafuni' (The Medium wealth category)} & \textbf{Abaavu – The poorest} \\ \hline Income (financial capital) & Income generating activity e.g. shop or other business with capitalization from 400,000 – 1 million UGX & Low earning, unable to save & - Unable to raise small amounts (2,000 Ushs) in a crisis e.g. police bond or cannot have on them 1000 Ushs - Lacks a job that can bring in daily income - May have small amount of capital from 20,000 – 30,000 Ushs \\ \hline Assets (physical and natural capital) & Means of transport – car or motorcycle; House – building materials – bricks, plastered walls, iron sheets, glass windows; state of maintenance and surrounding compound as important as building materials; Farmed land up to 5 acres & Cows, goats, hens with value up to 100,000 Ushs & Doesn't have anything Squalid home Poor beddings No material things to sell \\ \hline Occupation & Self-employed in some business & Primary school teachers, petty traders & Does not work due to advanced age, illness, irresponsible social behavior, appearance (cannot obtain employment) Employment of casual nature \\ \hline Ability to survive & Can obtain all needs in a timely manner without straining themselves & Can solve problems of magnitude up to 100,000 & - Lives hand to mouth - Cannot survive without borrowing or asking for assistance - Survives on social/community support e.g. needs to borrow or ask for help to obtain certain elements for survival - Usually lacks close family relatives \\ \hline \end{tabular} \end{table}
PMC2717964_table_0
\begin{table} \centering \label{tab:tablelabel} \begin{tabular}{|l|l|l|l|l|l|} \hline \textbf{Category} & \textbf{Total number of participants} & \textbf{Men} & \textbf{Women} & \textbf{Occupations of participants} & \textbf{Other observations} \\ \hline Least Poor "Abagaiga" & 8 & 5 & 3 & Mulimi (1 acre of rice, 1 acre of maize), produce buyer; Affiliate manager for habitat for humanity; health worker/nurse; peasant animal farmer with 1–2 cows & Observation – the rich were contacting each other with mobile phones to come for the meeting \\ \hline Middle wealth category "Abafuni" & 15 & 11 & 4 & Mainly peasant farmers who also trade in farm produce, rear chicken, goats for trade on a small scale, primary school teachers \\ \hline Poorest "Abaavu" & 12 & 11 & 1 & Types of occupation present – peasant crop farmers (ages, 23, 47, 55 yrs), local security man, 70 year old – can't dig anymore, another too old to work since 1992 has been sickly, not able to work, another urethral obstruction, difficult vision, no savings; no energy to dig has hernia, backache, poor vision 62 year old, 48 year old – no job, casual laborer. & The LC 1 chairman was present at this meeting \\ \hline \end{tabular} \end{table}
PMC2717964_table_1
\begin{table} \centering \label{tab:tablelabel} \begin{tabular}{|l|l|l|l|l|} \hline \textbf{Village name} & \textbf{Least Poor} & \textbf{Medium wealth category} & \textbf{Poorest} & \textbf{Total} \\ \hline Nawangisa & 8 & 15 & 12 & 35 \\ \hline Men & 5 & 11 & 11 & 27 \\ \hline Women & 3 & 4 & 1 & 8 \\ \hline Kakongoka & 9 & 8 & 8 & 25 \\ \hline Men & 5 & 4 & 4 & 13 \\ \hline Women & 4 & 4 & 4 & 12 \\ \hline Namundudi & 7 & 12 & 9 & 28 \\ \hline Men & 5 & 6 & 5 & 16 \\ \hline Women & 2 & 6 & 4 & 12 \\ \hline \textbf{Total} & 24 & 35 & 29 & 88 \\ \hline \end{tabular} \end{table}
PMC2717964_table_2
\begin{table} \centering \label{tab:tablelabel} \begin{tabular}{|l|l|l|l|l|l|l|l|} \hline & & & \multicolumn{5}{c|}{\textbf{Weight of tumor (g)}} \\ \hline \textbf{Group (n = 12)} & \textbf{Dose (mg/kg)} & \textbf{Inhibition rate (\%)} & \textbf{Mean} & \textbf{SD} & \multicolumn{3}{c|}{\textbf{Percentiles}} \\ \hline & & & & & \textbf{25th} & \textbf{50th (median)} & \textbf{75th} \\ \hline Control & - & - & 1.368 & 0.388 & 1.070 & 1.229 & 1.718 \\ \hline \multirow{2}{*}{Cyclophosphamide} & 60 × 1 & 67.81 & 0.440 & 0.084 & 0.371 & 0.415*** & 0.523 \\ \hline 2 × 6 & 42.85 & 0.782 & 0.154 & 0.634 & 0.790*** & 0.946 \\ \hline \multirow{2}{*}{Acetylshikonin} & 1 × 6 & 21.86 & 1.067 & 0.214 & 0.850 & 1.010* & 1.273 \\ \hline 0.5 × 6 & 11.11 & 1.307 & 0.364 & 0.962 & 1.376 & 1.640 \\ \hline \end{tabular} \end{table}
PMC2717966_table_0
\begin{table} \centering \label{tab:tablelabel} \begin{tabular}{|l|l|l|l|l|l|l|} \hline & & & & \multicolumn{3}{c|}{\textbf{Percentiles}} \\ \hline \textbf{Group (n = 10)} & \textbf{Dose (mg/kg)} & \textbf{Mean} & \textbf{SD} & \textbf{25th} & \textbf{50th (median)} & \textbf{75th} \\ \hline Bax \\ \hline Control & - & 13633 & 2531 & 11244 & 13712 & 15634 \\ \hline \multirow{3}{*}{Acetylshikonin} & 2 × 6 & 48678 & 2534 & 46432 & 48519*** & 51406 \\ \hline 1 × 6 & 28502 & 5064 & 23628 & 30232*** & 33082 \\ \hline 0.5 × 6 & 21844 & 4882 & 16476 & 22988** & 26209 \\ \hline bcl-2 \\ \hline Control & - & 19859 & 2822 & 17076 & 20065 & 22292 \\ \hline \multirow{3}{*}{Acetylshikonin} & 2 × 6 & 8126 & 1115 & 7267 & 7926*** & 8596 \\ \hline 1 × 6 & 11171 & 1459 & 9916 & 10814*** & 12478 \\ \hline 0.5 × 6 & 15652 & 1724 & 14447 & 15234** & 16742 \\ \hline Bax/bcl-2 \\ \hline Control & - & 0.70 & 0.17 & 0.58 & 0.74 & 0.79 \\ \hline \multirow{3}{*}{Acetylshikonin} & 2 × 6 & 6.11 & 0.92 & 5.54 & 6.05*** & 6.26 \\ \hline 1 × 6 & 2.56 & 0.36 & 2.34 & 2.47*** & 2.77 \\ \hline 0.5 × 6 & 1.41 & 0.32 & 1.14 & 1.29** & 1.77 \\ \hline Caspase-3 \\ \hline Control & - & 12746 & 3155 & 10359 & 12019 & 13714 \\ \hline \multirow{3}{*}{Acetylshikonin} & 2 × 6 & 31618 & 3155 & 29396 & 31226*** & 33530 \\ \hline 1 × 6 & 22653 & 4647 & 18898 & 21756*** & 25119 \\ \hline 0.5 × 6 & 13582 & 3737 & 10009 & 13186 & 17705 \\ \hline \end{tabular} \end{table}
PMC2717966_table_1
\begin{table} \centering \label{tab:tablelabel} \begin{tabular}{|l|l|l|} \hline \textbf{Accession} & \textbf{Name} & \textbf{Def allele} \\ \hline JI 116 & cv. Parvus & Def (wild type) \\ \hline JI 2822 & RIL, research line & Def (wild type) \\ \hline JI 1184 & Priekuskij-341-def & def (mutant) \\ \hline JI 3020 & cv. Nord & def (mutant) \\ \hline \end{tabular} \end{table}
PMC2717967_table_0
\begin{table} \centering \label{tab:tablelabel} \begin{tabular}{|l|l|l|l|l|} \hline \textbf{Gene identification/Gene description} & \textbf{E value/ID (\%)} & \textbf{Primer sequence/Amplicon size} & \textbf{Amplification efficiency $\pm$ SD*} & \textbf{GeneBank Accession Number} \\ \hline BbrizEF1 Elongation factor-1 alpha & 4e-89/ 166/179 (92\%) & 5'ACCCTCCTCTTGGTCGTT TT3' 5'AGCCCCTCATTTCTTCTT GG 3' 105 bp & 0.87 $\pm$ 0.012 & EZ000623 \\ \hline BbrizEIF4A Eukaryotic initiation factor 4A & 4e-41/ 88/100 (88\%) & 5'TAAGGTGGGGCTTGTTTT TG3' 5'ACAGCAGCACATACCACA GG3' 164 bp & 0.94 $\pm$ 0.011 & EZ000622 \\ \hline BbrizGAPDH glucose-6-phosphate dehydrogenase & 2e-39/ 86/121 (71\%) & 5'TGAATCTAGTCCATCCGC TTG3' 5'TCATCAGGCAGGGAAGCT A3' 124 bp & 0.97 $\pm$ 0.009 & GE617483 \\ \hline BbrizGDP glyceroldehyde-3-phosphate dehydrogenase & 6e-22/ 48/55(87\%) & 5'GGGCATTTTGGGTTATGT TG3' 5'TCCCCACTCGTTGTCATA CC3' 146 bp & 1.01 $\pm$ 0.009 & EZ000624 \\ \hline BbrizSUCOA succinyl-CoA ligase (GDP- forming) beta-chain & e-107/ 203/236 (86\%) & 5'CAGCAAGGGAGGAACCAG TA3' 5'TAGCGCAAGACCATCAAC AA3' 130 bp & 1.00 $\pm$ 0.008 & GE617476 \\ \hline BbrizTUB putative tubulin alpha-5 chain & 4e-51/ 96/98 (97\%) & 5'ATGAAGGCGATGAAGGAG AA3' 5'GTACGCAATGGAATGGAA CC3' 112 bp & 1.01 $\pm$ 0.019 & GE617477 \\ \hline BbrizUBCE1 Ubiquitin-conjugating enzyme BbrizUBCE2 & 4e-31/ 64/74 (86\%) & 5'GGTCTTGCTCTCCATCTG CT3' 5'CGGGCTGTCGTCTCATAC TT3' 114 bp 5'ACCAGCACAAATCAAAGG A3' 5'GCCAAAGTATGAGACGAC AGC3' 149 bp & 0.92 $\pm$ 0.013 0.95 $\pm$ 0.015 & GE617481 \\ \hline BbrizUBI ubiquitin/ribosomal protein & 4e-06/ 28/49 (57\%) & 5'GTCACTAAGCCATCGGTC GT3' 5'ACACGGACACAACCAGTT CA3' 112 bp & 0.94 $\pm$ 0.020 & GE617482 \\ \hline \end{tabular} \end{table}
PMC2717968_table_0
\begin{table} \centering \label{tab:tablelabel} \begin{tabular}{|l|l|l|l|} \hline \textbf{Exons} & \textbf{PCR product size (bp)} & \textbf{PCR anealing temperature (°C)} & \textbf{Primers} \\ \hline \multirow{2}{*}{1A} & 305 & 62 & F 5'-CTTGAACCCGCGAACAGGCGA \\ \hline & & R 5'-TCTCGGGCACCTGCGCTGGA \\ \hline \multirow{2}{*}{1B} & 365 & 68 & F 5'-GCAGAGCAGCGGCAGCGGGTAT \\ \hline & & R 5'-TATTTTACCGCCGCGCGGCGCA \\ \hline \multirow{2}{*}{2} & 241 & 65 & F 5'-CTCAAGAAAGGGGCTAACTTCTCAA \\ \hline & & R 5'-GCACTTCCTGGCTTTTAAGATTGGG \\ \hline \multirow{2}{*}{3+4} & 352 & 60 & F 5'-CAGGCCAACTTCTAACCACACACCT \\ \hline & & R 5'-CCGAAGCTGGCCATGCTGGG \\ \hline \multirow{2}{*}{5} & 295 & 65 & F 5'-CTGTCTGTGTGTCTGTCTGTCC \\ \hline & & R 5'-GGCCAGCCTGGCAGGCGGGAAGG \\ \hline \multirow{2}{*}{6} & 264 & 58 & F 5'-ACTCCCCGAAGAGGGGTTCAAGG \\ \hline & & R 5'-GAGGCTCCTGAGTACCACCC \\ \hline \multirow{2}{*}{7} & 234 & 65 & F 5'-CAAGGTCAGTTCCTCCACCTTGCC \\ \hline & & R 5'-GAAGAGTAGCCCTGCAGGGTGACT \\ \hline \multirow{2}{*}{8} & 164 & 72 & F 5'-GGAGCTAAGGCGAGCTCTGGC \\ \hline & & R 5'-GGCATGCTCCTGGGGACTGGG \\ \hline \multirow{2}{*}{9} & 253 & 72 & F 5'-CAAGGAGCCCATTCTCTCCCTT \\ \hline & & R 5'-TGCCTTGCTGGGCCTCGAAGG \\ \hline \multirow{2}{*}{10} & 318 & 72 & F 5'-CTGAGAGAGCTGGTGCTGAGG \\ \hline & & R 5'-AGGCCGCCCACCCTCCACACT \\ \hline \multirow{2}{*}{11} & 160 & 65 & F 5'-GCAGGCAGTGGCATCAGCAAG \\ \hline & & R 5'-CCCCATAGCCCACAGGTATGCAGG \\ \hline \multirow{2}{*}{12+13A} & 368 & 72 & F 5'-TGTGTGCCACCGGCCTCCCA \\ \hline & & R 5'-GGGAAGGAGGGTGGCCGTGG \\ \hline \multirow{2}{*}{13B} & 364 & 68 & F 5'-GTGGGTGAACCCCCACAAGGTC \\ \hline & & R 5'-TGGCCCCACTCAGGAGTGAGAC \\ \hline \multirow{2}{*}{13C} & 377 & 68 & F 5'-CCATTCGTCTGTCCCAGAGCTTA \\ \hline & & R 5'-TGGGACAAGGAAGTGGGTCCTCA \\ \hline \end{tabular} \end{table}
PMC2717975_table_0
\begin{table} \centering \label{tab:tablelabel} \begin{tabular}{|l|l|l|l|l|l|l|l|} \hline & & & & \multicolumn{2}{c|}{\textbf{Haemoglobinuria Kinh N = 82}} & \textbf{Healthy Kinh N = 266} & \textbf{Healthy S'tieng N = 258} \\ \hline \textbf{Variant} & \textbf{Variant} name & \textbf{Amino acid substitution} & \textbf{Mutation classa} & \textbf{G6PD+ N = 34} & \textbf{G6PD- N = 48} & \textbf{G6PD- N = 23} & \textbf{G6PD- N = 36} \\ \hline Non-synonomous \\ \hline G7A & Vietnam 1 & Glu3Lys & * & & 1 \\ \hline A95G & Gaohe Gaozhou & His32Arg & 3 & & 1 \\ \hline T10148G & Vietnam 2 & Phe66Cys & * & & & 1 \\ \hline C11763T & Coimbra Shunde & Arg198Cys & 2 & 1 & & 1 \\ \hline G13031A & Viangchan Jammu & Val291Met & 3,2 & 1 & 17 & 2 & 13 \\ \hline C13184T & Chinese-5 & Leu342Phe & 3 & 0 & 1 & 3 & 1 \\ \hline synonomous \\ \hline C10170T & Vietnam 3 & Ser73Ser & & & & 1 \\ \hline C13714T & nt13714C>T & Tyr437Tyr & & 10 & 14 & 9 & 21 \\ \hline \end{tabular} \end{table}
PMC2717975_table_1
\begin{table} \centering \label{tab:tablelabel} \begin{tabular}{|l|l|l|l|l|l|l|l|} \hline \textbf{G6PD} & \textbf{Hburiac Kinh N = 82} & \textbf{Healthy Kinh N = 266} & Hburia Kinh \textbf{G6PD}- N = 48 & Healthy Kinh \textbf{G6PD}- N = 23 & \textbf{OR} & \textbf{95\%CI} & \textbf{P value} \\ \hline deficiencya & 48 & 23 & & & 14.9 & 7.74 – 28.9 & < 0.0001 \\ \hline definiteb & 23 & 23 & & & 4.11 & 2.04–8.24 & < 0.0001 \\ \hline Viangchan Jammu & & & 17 & 2 & 5.7 & 1.14 – 55.4 & 0.022 \\ \hline Chinese-5 & & & 1 & 3 & 0.14 & 0.002 – 1.9 & 0.09 \\ \hline Vietnam 1 & & & 1 & 0 \\ \hline Gaohe Gaozhou & & & 1 & 0 \\ \hline Vietnam 2 & & & 0 & 1 \\ \hline \end{tabular} \end{table}
PMC2717975_table_2