text
stringlengths 0
122k
| embeddings_A
sequence | embeddings_B
sequence |
---|---|---|
BACKGROUND: In natural cat populations, Feline Immunodeficiency Virus (FIV) is transmitted through bites between individuals. Factors such as the density of cats within the population or the sex-ratio can have potentially strong effects on the frequency of fight between individuals and hence appear as important population risk factors for FIV. METHODOLOGY/PRINCIPAL FINDINGS: To study such population risk factors, we present data on FIV prevalence in 15 cat populations in northeastern France. We investigate five key social factors of cat populations; the density of cats, the sex-ratio, the number of males and the mean age of males and females within the population. We overcome the problem of dependence in the infective status data using sexually-structured dynamic stochastic models. Only the age of males and females had an effect (p = 0.043 and p = 0.02, respectively) on the male-to-female transmission rate. Due to multiple tests, it is even likely that these effects are, in reality, not significant. Finally we show that, in our study area, the data can be explained by a very simple model that does not invoke any risk factor. CONCLUSION: Our conclusion is that, in host-parasite systems in general, fluctuations due to stochasticity in the transmission process are naturally very large and may alone explain a larger part of the variability in observed disease prevalence between populations than previously expected. Finally, we determined confidence intervals for the simple model parameters that can be used to further aid in management of the disease. | [
-0.016631577163934708,
0.013000606559216976,
-0.007555178366601467,
0.016908878460526466,
0.031210413202643394,
-0.010779247619211674,
0.009119557216763496,
0.00207726052030921,
-0.012812870554625988,
-0.019164036959409714,
-0.004462104290723801,
0.01736004650592804,
-0.009475409053266048,
0.022136591374874115,
-0.0031706010922789574,
0.006565244868397713,
-0.021858997642993927,
-0.001989092445001006,
0.003266241867095232,
0.010751649737358093,
-0.009705398231744766,
0.003691768739372492,
0.009350934997200966,
-0.006034573540091515,
-0.04763731360435486,
-0.02158120647072792,
0.015233809128403664,
-0.01795167662203312,
-0.00226014805957675,
-0.014957165345549583,
0.015888292342424393,
0.029163237661123276,
-0.028526877984404564,
0.011348223313689232,
0.02554720640182495,
0.007688937708735466,
0.002041424624621868,
0.01787526160478592,
-0.018109258264303207,
-0.0039061217103153467,
0.004536541644483805,
-0.00606944877654314,
0.0067028747871518135,
-0.016194840893149376,
-0.0055240606889128685,
0.027160372585058212,
-0.002222660696133971,
-0.009707286022603512,
-0.008942458778619766,
0.008911271579563618,
0.003780789440497756,
-0.02137138694524765,
-0.022344015538692474,
-0.011257448233664036,
-0.005518343765288591,
0.012078488245606422,
0.019455473870038986,
-0.0009172961581498384,
-0.0050423284992575645,
0.012693974189460278,
0.006609909236431122,
-0.00928979367017746,
0.00738031230866909,
-0.008336339145898819,
0.026329487562179565,
-0.06714425981044769,
-0.03070889227092266,
-0.005346026737242937,
0.008141337893903255,
-0.0011133069638162851,
0.011726299300789833,
0.00704277865588665,
0.018803393468260765,
-0.023939283564686775,
0.015653183683753014,
-0.029820743948221207,
0.004432187415659428,
0.03479710966348648,
-0.00887810904532671,
0.02176021784543991,
0.02593890205025673,
0.006080583203583956,
-0.009383028373122215,
0.025673454627394676,
-0.007611404173076153,
0.02201826125383377,
-0.01833876222372055,
-0.003614913672208786,
-0.014242159202694893,
0.01810755953192711,
0.02097480371594429,
-0.011144322343170643,
-0.004296553321182728,
0.0023317430168390274,
-0.014041811227798462,
-0.0021347266156226397,
-0.02872343733906746,
-0.00026550330221652985,
0.003152186516672373,
-0.006637936923652887,
0.008894412778317928,
-0.00002402905374765396,
0.013523029163479805,
0.014364037662744522,
0.036911629140377045,
0.009480711072683334,
-0.0009415786480531096,
-0.016551317647099495,
-0.0038427209947258234,
0.008688770234584808,
-0.0033401758410036564,
0.011984307318925858,
0.009097294881939888,
-0.024709949269890785,
0.003056061454117298,
0.0004579457454383373,
-0.031058065593242645,
0.012341161258518696,
0.010028292424976826,
0.0037918619345873594,
0.030047612264752388,
-0.005622006021440029,
-0.0023249590303748846,
0.015600992366671562,
0.002833961509168148,
-0.007721687667071819,
0.010133307427167892,
0.008655678480863571,
0.00506278220564127,
-0.0019825147464871407,
-0.006030555814504623,
-0.008909478783607483,
-0.0033905780874192715,
-0.011084875091910362,
0.005875332280993462,
0.005873648449778557,
0.011900791898369789,
-0.0018062964081764221,
-0.002275776583701372,
-0.002327512949705124,
-0.02806483581662178,
0.009378667920827866,
0.0016988019924610853,
0.004335613455623388,
0.012179977260529995,
-0.004669276066124439,
-0.03504898399114609,
0.01659398153424263,
0.015140208415687084,
0.005804770160466433,
0.022086896002292633,
-0.02384796179831028,
0.005900475662201643,
-0.01757846400141716,
0.003131240140646696,
-0.006703945808112621,
-0.014034705236554146,
0.0012304068077355623,
0.009954815730452538,
0.009827998466789722,
0.004022407811135054,
0.021125972270965576,
0.030048910528421402,
0.008256334811449051,
0.015843834728002548,
0.012347696349024773,
0.006215984467417002,
-0.009272517636418343,
0.00046719296369701624,
0.005484027322381735,
-0.0043725501745939255,
0.010921511799097061,
0.007472006604075432,
0.010474702343344688,
-0.014637643471360207,
-0.000742863048799336,
0.030644932761788368,
0.008131138980388641,
-0.0037030125968158245,
0.06696687638759613,
-0.009422089904546738,
-0.003929869271814823,
-0.017218828201293945,
-0.022597426548600197,
-0.005544847343116999,
-0.019187279045581818,
0.02456093207001686,
-0.013943642377853394,
0.023233622312545776,
-0.008517708629369736,
0.011889949440956116,
-0.00727644469588995,
0.0003181459615007043,
0.00518473144620657,
-0.014942245557904243,
0.004221764393150806,
0.007295847870409489,
0.011384736746549606,
0.018746234476566315,
0.016135362908244133,
-0.0036428961902856827,
-0.016619645059108734,
0.04713935777544975,
-0.011519437655806541,
-0.04003683477640152,
0.008265724405646324,
0.016853291541337967,
-0.005233522970229387,
-0.0006598725449293852,
0.02138226106762886,
0.015866216272115707,
-0.005485949106514454,
0.01793765276670456,
-0.026479823514819145,
0.026385311037302017,
-0.01908383145928383,
-0.009258810430765152,
0.00518410187214613,
-0.013918733224272728,
-0.014631841331720352,
-0.004887566901743412,
0.015270419418811798,
-0.012411324307322502,
-0.00901039782911539,
0.008927473798394203,
-0.0010713012889027596,
0.0025992407463490963,
0.008556701242923737,
-0.016375243663787842,
-0.006166110746562481,
0.0004564053378999233,
-0.024174464866518974,
-0.005948562640696764,
0.013388191349804401,
0.023998074233531952,
-0.007822403684258461,
0.00834728218615055,
-0.0001353435218334198,
0.014108119532465935,
-0.0067067197524011135,
-0.004733023699373007,
-0.010049058124423027,
0.007531812414526939,
-0.012112257070839405,
0.015203878283500671,
-0.009367551654577255,
0.0379725806415081,
-0.0019569420255720615,
0.002561134286224842,
-0.019806191325187683,
0.0038530451711267233,
0.01617523655295372,
-0.0014731375267729163,
-0.001182557549327612,
0.0073589445091784,
0.008470416069030762,
0.00796697847545147,
-0.002613930031657219,
0.023799661546945572,
0.017627917230129242,
0.014727510511875153,
0.003832001704722643,
-0.034001387655735016,
-0.01020699180662632,
0.006291962694376707,
0.027007194235920906,
-0.018593020737171173,
0.025249363854527473,
0.011310558766126633,
0.024656139314174652,
0.0050817932933568954,
-0.008233090862631798,
-0.00810591783374548,
-0.08189372718334198,
-0.010414708405733109,
-0.0009457834530621767,
-0.027128368616104126,
0.006025564856827259,
-0.002134314738214016,
-0.008204457350075245,
-0.017570730298757553,
0.0006674666656181216,
-0.0051101138815283775,
0.011258557438850403,
0.013726718723773956,
-0.002808904042467475,
-0.029608963057398796,
-0.003927120007574558,
-0.000661673373542726,
-0.003874024609103799,
0.01997310109436512,
-0.022183358669281006,
-0.0007996279746294022,
-0.01266086008399725,
-0.019008982926607132,
0.02650848962366581,
-0.008047289215028286,
0.005270735360682011,
0.01084385346621275,
0.022635050117969513,
0.004349005874246359,
0.004613705910742283,
0.003289897693321109,
0.0279984250664711,
-0.014026450924575329,
0.022250404581427574,
-0.017602464184165,
0.02035195380449295,
0.006434669718146324,
0.0035519921220839024,
-0.023661429062485695,
-0.016499871388077736,
-0.020750675350427628,
0.01462909672409296,
0.008958585560321808,
-0.019675076007843018,
0.0022211705800145864,
0.0018334516789764166,
0.0017647398635745049,
0.011495542712509632,
0.008331636898219585,
0.012279920279979706,
0.01341877318918705,
-0.029353847727179527,
-0.007521077990531921,
0.008256500586867332,
0.005634560715407133,
-0.0068209124729037285,
-0.020563354715704918,
0.02158566564321518,
-0.011090066283941269,
-0.020382773131132126,
-0.02128501422703266,
0.0034191389568150043,
-0.0032710754312574863,
0.005074072629213333,
0.0067277331836521626,
-0.019839555025100708,
0.0067610349506139755,
0.00650441600009799,
0.03476497158408165,
-0.0238984115421772,
0.009122916497290134,
0.03151501342654228,
0.0074493130668997765,
0.007669833488762379,
-0.0049146125093102455,
0.016457589343190193,
-0.006586655508726835,
-0.011271442286670208,
0.001322094933129847,
0.018273694440722466,
0.021209726110100746,
0.0036229779943823814,
-0.004099821671843529,
0.009025489911437035,
0.005997421685606241,
-0.015164156444370747,
0.016224637627601624,
0.010766079649329185,
0.023026010021567345,
0.01985754631459713,
-0.017132466658949852,
0.04699074476957321,
-0.009135980159044266,
0.0027907034382224083,
0.010822799056768417,
-0.021106049418449402,
-0.017664683982729912,
0.004740622825920582,
-0.003414698876440525,
0.009412234649062157,
0.00874936580657959,
-0.000905254390090704,
0.011064940132200718,
-0.022876404225826263,
-0.00568295456469059,
0.023019665852189064,
0.0181502103805542,
0.0072136735543608665,
0.005780923180282116,
-0.03775797039270401,
-0.009155424311757088,
-0.0042236847802996635,
0.02641712874174118,
-0.0027727270498871803,
0.021957095712423325,
0.010250488296151161,
0.002112490125000477,
0.009451467543840408,
0.010169467888772488,
0.07243561744689941,
0.00646578473970294,
0.011422477662563324,
-0.013916049152612686,
-0.004298666026443243,
-0.009457889012992382,
0.0074362121522426605,
-0.0046715023927390575,
0.019943244755268097,
-0.024131137877702713,
0.011339218355715275,
-0.048911213874816895,
-0.0044428883120417595,
-0.019769497215747833,
-0.013605715706944466,
0.013288233429193497,
-0.006675880402326584,
-0.02085873857140541,
0.019725769758224487,
0.021289661526679993,
0.011003718711435795,
-0.0008758604526519775,
0.0005432050675153732,
-0.03312397003173828,
0.027603760361671448,
-0.019273411482572556,
0.008600030094385147,
-0.013445492833852768,
-0.02347930520772934,
0.002057309728115797,
0.004138822667300701,
-0.017597343772649765,
-0.0037480199243873358,
-0.006773721426725388,
0.014442463405430317,
-0.010484786704182625,
-0.03275054693222046,
-0.013761782087385654,
-0.005192323122173548,
0.004803245421499014,
-0.002996037947013974,
-0.01198679581284523,
-0.005646928213536739,
0.012125255540013313,
-0.0271798986941576,
-0.0013992148451507092,
0.021506313234567642,
-0.00696305837482214,
-0.013798670843243599,
0.002821529284119606,
0.0015963197220116854,
0.012950947508215904,
0.006762966047972441,
0.0383191779255867,
0.0011655077105388045,
-0.00565223628655076,
0.016716085374355316,
0.0011915985960513353,
0.00018759549129754305,
0.016900882124900818,
0.014648882672190666,
0.013495318591594696,
0.012407355941832066,
-0.014137466438114643,
-0.013750999234616756,
-0.01289670355618,
-0.00416080467402935,
0.00536552257835865,
-0.02385128289461136,
0.020871706306934357,
0.05028846859931946,
-0.00047179171815514565,
-0.01183236949145794,
-0.019704550504684448,
0.004299325868487358,
0.028337720781564713,
-0.013111756183207035,
0.001429213210940361,
0.01309590507298708,
-0.017458133399486542,
0.018956713378429413,
-0.001273132860660553,
0.03028046153485775,
-0.02544485032558441,
0.003936887718737125,
-0.006689662113785744,
-0.02963494136929512,
-0.07477126270532608,
-0.0062894755974411964,
0.024270500987768173,
-0.008511204272508621,
-0.0027569420635700226,
0.008711987175047398,
-0.002794870175421238,
-0.018527686595916748,
-0.005134236998856068,
-0.010497057810425758,
-0.006720492150634527,
-0.030907057225704193,
0.003725253976881504,
0.0031580550130456686,
0.01557701826095581,
-0.015534590929746628,
-0.016281433403491974,
-0.0010881803464144468,
-0.0019997446797788143,
0.0035417857579886913,
0.003946131095290184,
0.009633976966142654,
-0.022656816989183426,
-0.004269859287887812,
0.006691897753626108,
-0.08133196830749512,
0.01990608125925064,
0.018884319812059402,
-0.0014280045870691538,
0.021278217434883118,
-0.03914917632937431,
0.0031958208419382572,
-0.028459664434194565,
-0.014394832774996758,
-0.018899913877248764,
-0.029587527737021446,
-0.01415875181555748,
-0.014793800190091133,
0.00641266256570816,
0.009039454162120819,
-0.0061659435741603374,
0.012256273999810219,
0.004117327276617289,
-0.006289856508374214,
-0.008307366631925106,
0.009042065590620041,
0.004630275070667267,
-0.008677182719111443,
0.0006866995245218277,
-0.012796568684279919,
-0.00990355759859085,
-0.00662624929100275,
0.0013422271003946662,
0.021716151386499405,
0.021750785410404205,
0.012081677094101906,
0.012407496571540833,
-0.0028012236580252647,
0.0032161041162908077,
0.007537578232586384,
-0.010434265248477459,
-0.007293039001524448,
-0.004622706212103367,
0.014867600984871387,
0.004230069927871227,
-0.002669166075065732,
-0.010376492515206337,
0.022733494639396667,
0.0009386236779391766,
-0.015075777657330036,
-0.018220186233520508,
0.00746275344863534,
-0.011759953573346138,
0.020977474749088287,
-0.000003968598321080208,
0.01659681648015976,
-0.007403017021715641,
-0.016944361850619316,
-0.013243820518255234,
-0.018793080002069473,
-0.0034997137263417244,
-0.008487083949148655,
0.01143145002424717,
-0.003411648329347372,
0.02192031778395176,
0.007178825326263905,
0.01167663000524044,
0.002740694209933281,
0.07214230298995972,
-0.022122859954833984,
-0.0037545098457485437,
-0.010553324595093727,
-0.008589097298681736,
-0.003104039002209902,
-0.015969250351190567,
-0.015391708351671696,
-0.009691055864095688,
-0.03946521878242493,
-0.019060693681240082,
-0.010610923171043396,
0.007760937791317701,
0.0152521887794137,
0.023455053567886353,
-0.012914154678583145,
-0.006598742678761482,
0.03021729737520218,
-0.03120042011141777,
0.0033192893024533987,
0.0030492343939840794,
-0.0027256510220468044,
-0.04212526977062225,
0.0034484239295125008,
0.009157792665064335,
-0.0034368792548775673,
0.005037887487560511,
0.009065669029951096,
-0.0076689464040100574,
0.0049860114231705666,
-0.009813768789172173,
0.001352394581772387,
0.004810825455933809,
-0.02292811870574951,
0.01042177714407444,
-0.014028453268110752,
0.022257156670093536,
-0.0008353556040674448,
0.018439780920743942,
0.01347360573709011,
0.006437239702790976,
-0.0003316253423690796,
-0.0021502631716430187,
-0.023387273773550987,
0.022913817316293716,
-0.015012765303254128,
0.003908875398337841,
0.004897266160696745,
-0.022858086973428726,
0.0069197542034089565,
0.010964816436171532,
0.010421629063785076,
0.00813488382846117,
0.012277984991669655,
-0.023398593068122864,
-0.0040944465436041355,
-0.0033888397738337517,
0.023791110143065453,
-0.01223940122872591,
-0.01397163886576891,
-0.017293062061071396,
-0.008040716871619225,
0.003326627891510725,
-0.01321965642273426,
-0.014252373948693275,
-0.028249382972717285,
0.01798129454255104,
-0.009240643121302128,
-0.019025322049856186,
0.015675615519285202,
-0.011127086356282234,
0.009332665242254734,
0.005603066645562649,
0.0047952160239219666,
-0.005531095899641514,
0.008448895066976547,
0.008324745111167431,
0.009184271097183228,
0.002766137709841132,
0.014844409190118313,
-0.016185063868761063,
-0.009652731940150261,
0.006133519113063812,
-0.0585031695663929,
0.03532378375530243,
0.012633714824914932,
0.031248796731233597,
0.004047716502100229,
-0.007987559773027897,
0.007752345409244299,
0.021227141842246056,
0.01080628577619791,
-0.005140203982591629,
0.01829920895397663,
0.009780107997357845,
0.03446255996823311,
-0.011796504259109497,
0.014443445950746536,
0.004638876765966415,
0.010326163843274117,
0.0015942842001095414,
-0.012964358553290367,
0.013421435840427876,
0.009942708536982536,
-0.017042653635144234,
-0.003123068017885089,
0.01095055416226387,
0.018446218222379684,
0.009494439698755741,
-0.011836694553494453,
0.02436952292919159,
0.04645388573408127,
0.013191786594688892,
0.03025643154978752,
0.00728411041200161,
-0.015843166038393974,
0.0009036681731231511,
-0.0038959402590990067,
0.007308374159038067,
-0.004299325868487358,
0.011309648863971233,
-0.017656560987234116,
-0.003883061930537224,
0.017755843698978424,
-0.008365936577320099,
-0.029773306101560593,
-0.0024424493312835693,
-0.004404687322676182,
0.018445242196321487,
0.01000915002077818,
0.01510408241301775,
-0.019712278619408607,
0.017833247780799866,
-0.007688906043767929,
0.0014975911471992731,
-0.01355521846562624,
0.015576710924506187,
0.0022315913811326027,
0.013660910539329052,
-0.02061530016362667,
0.014065390452742577,
-0.0014503640122711658,
0.006069705821573734,
-0.008839272893965244,
0.00826437771320343,
0.021285485476255417,
0.019104529172182083,
0.06091037765145302,
0.009730723686516285,
0.00143068702891469,
-0.010384252294898033,
-0.0032668167259544134,
0.0050927819684147835,
-0.004885359667241573,
0.007007945328950882,
0.010551068931818008,
0.007838401943445206,
-0.04287131130695343,
-0.00213577039539814,
0.005838378798216581,
0.009382106363773346,
-0.0020716190338134766,
-0.005744732450693846,
-0.001628032885491848,
0.01896459236741066,
-0.0013721906580030918,
-0.017370382323861122,
-0.002704557264223695,
-0.021470554172992706,
0.02538590133190155,
-0.01725706271827221,
-0.025306645780801773,
0.012768670916557312,
0.02621428295969963,
0.009103402495384216,
-0.011630848981440067,
0.0008629882941022515,
0.020577246323227882,
-0.031105365604162216,
0.020503414794802666,
0.019941989332437515,
-0.003522177692502737,
0.014406880363821983,
-0.0032763504423201084,
0.016541119664907455,
0.00952612329274416,
0.003889114363119006,
0.01737246662378311,
0.021893398836255074,
-0.002418315503746271,
-0.02256147935986519,
-0.019992370158433914,
-0.004018465522676706,
-0.0033331182785332203,
-0.01282049622386694,
-0.01323714479804039,
-0.019476545974612236,
-0.028226403519511223,
-0.0022089022677391768,
0.012472938746213913,
-0.0017403748352080584,
-0.006962055340409279
] | [
0.7692790031433105,
-0.16946852207183838,
-0.3661883771419525,
-0.0350860096514225,
0.10034053772687912,
0.41139236092567444,
0.575886607170105,
0.3103146255016327,
-0.4972971975803375,
-0.46544399857521057,
-0.1347009241580963,
0.26657503843307495,
-0.11136656254529953,
0.09115859866142273,
-0.45207440853118896,
0.8712413311004639,
0.44123581051826477,
0.25007325410842896,
0.030660375952720642,
-0.2709461748600006,
-0.6363133192062378,
-0.5609216094017029,
0.06879306584596634,
0.33013054728507996,
0.27900660037994385,
0.017496028915047646,
0.5041242837905884,
0.6476999521255493,
0.5309701561927795,
-0.1469878852367401,
0.1840321123600006,
0.2443801462650299,
-0.20687277615070343,
-0.4980112612247467,
-0.018349990248680115,
-0.41825070977211,
0.07361014932394028,
-0.14232349395751953,
0.1976659595966339,
-0.33145588636398315,
0.1067967340350151,
-0.08287665992975235,
-0.29521992802619934,
0.3752409815788269,
-0.20018790662288666,
-0.6838335990905762,
-0.8818362951278687,
0.6735005378723145,
0.025784838944673538,
0.14829576015472412,
0.32874250411987305,
0.08508098870515823,
-0.3699355721473694,
0.17567817866802216,
0.11246553808450699,
0.1443844586610794,
-0.569068968296051,
-0.20337598025798798,
0.24484023451805115,
-0.13348184525966644,
0.13195866346359253,
-0.007536000106483698,
0.11143282055854797,
0.13734674453735352,
-0.51426762342453,
0.526379406452179,
0.36693376302719116,
0.16113968193531036,
0.1406300961971283,
-0.33042699098587036,
0.054245755076408386,
-0.0654752179980278,
-0.3671448230743408,
0.00800284557044506,
-0.30442482233047485,
0.2653847634792328,
0.021808389574289322,
-0.3711586594581604,
0.5626437067985535,
0.35135960578918457,
0.028922416269779205,
-0.14926066994667053,
0.45218172669410706,
-0.6942575573921204,
0.7326685190200806,
0.4014875590801239,
0.024076854810118675,
0.44959309697151184,
-0.35442236065864563,
-0.0673559308052063,
-0.1744922250509262,
-0.3314064145088196,
0.1944950968027115,
0.3329867720603943,
-0.05324895307421684,
0.4467480182647705,
0.6513062119483948,
-0.3042248487472534,
0.3188358247280121,
0.0928744450211525,
-0.6479460597038269,
0.15592952072620392,
0.02469940483570099,
0.2755287289619446,
-0.4842795133590698,
-0.04985947161912918,
-0.3647320866584778,
-0.09705183655023575,
-0.9228357672691345,
0.33857253193855286,
-0.5312899351119995,
-0.15130186080932617,
-0.1666528731584549,
-0.3505777418613434,
-0.008681448176503181,
0.02457892894744873,
0.37564119696617126,
-0.4331178665161133,
0.2584407925605774,
0.5339246392250061,
-0.34431639313697815,
0.45542213320732117,
-0.2436058521270752,
0.6064130663871765,
0.05024445801973343,
0.12070728838443756,
0.5658535957336426,
0.1175466924905777,
-0.1863277703523636,
0.23916350305080414,
0.36292150616645813,
0.53162682056427,
-0.2346351444721222,
0.20759810507297516,
0.06505638360977173,
-0.31629377603530884,
-0.15832987427711487,
0.6116657853126526,
-0.09185381978750229,
-0.04548240453004837,
-0.7434130311012268,
-0.6030150651931763,
-0.3095035254955292,
0.3661022484302521,
0.08688057214021683,
-0.7553508281707764,
-0.1522616595029831,
-0.05866648629307747,
0.1755472868680954,
-0.2389356791973114,
-0.0557602234184742,
-0.10706644505262375,
-0.4744773507118225,
-0.18048395216464996,
-0.3993881046772003,
0.29886916279792786,
0.15659692883491516,
0.1354842334985733,
-0.05396249517798424,
0.07922772318124771,
0.7184463143348694,
0.5313600897789001,
-0.134847953915596,
-0.3159608244895935,
0.49979960918426514,
-0.3443942964076996,
-0.3279884457588196,
0.4216243624687195,
-0.30356088280677795,
0.3679341971874237,
-0.6279502511024475,
-0.11857976019382477,
-0.1736312359571457,
-0.6605616211891174,
-0.18080975115299225,
0.2834368050098419,
0.10809168964624405,
0.1282404661178589,
0.2841109335422516,
0.24004827439785004,
-0.4355691969394684,
-0.019124291837215424,
-0.058051466941833496,
-0.5512858629226685,
0.03127550706267357,
0.039834484457969666,
0.21980437636375427,
-0.04211430624127388,
0.09914717823266983,
-0.2924117147922516,
-0.24090899527072906,
-0.38810285925865173,
0.631482720375061,
-0.5943415760993958,
1.056809425354004,
-0.6229998469352722,
-0.0426679328083992,
1.6072134971618652,
0.15488706529140472,
0.04454278200864792,
-0.22834047675132751,
0.06542376428842545,
0.798827052116394,
0.0711369514465332,
-0.8316330909729004,
0.06680923700332642,
-0.22556628286838531,
-0.24516931176185608,
0.2767069935798645,
0.04229889437556267,
0.5488607287406921,
-0.05580969154834747,
-0.18417330086231232,
-0.2582050859928131,
0.19037415087223053,
0.31149110198020935,
-0.2820751368999481,
-0.03495793044567108,
0.4740886688232422,
0.10149599611759186,
0.31284987926483154,
-0.8017668128013611,
0.14824038743972778,
0.4445660412311554,
-0.2804408073425293,
0.30577942728996277,
0.6238827705383301,
0.1377364546060562,
1.144579291343689,
-0.7245919108390808,
-0.10226013511419296,
0.2675762176513672,
0.25441545248031616,
-0.8515968918800354,
-0.431784063577652,
0.06391002982854843,
0.1488589346408844,
0.07133985310792923,
-0.11209733039140701,
0.33896753191947937,
0.21517105400562286,
0.5049784779548645,
-0.5111179947853088,
0.14041806757450104,
-0.25789156556129456,
-0.23747171461582184,
-0.19639843702316284,
0.23000311851501465,
-0.4429703950881958,
-0.05947204679250717,
0.14321227371692657,
0.4646793603897095,
0.07056306302547455,
-0.5334638357162476,
0.16642573475837708,
-0.10707246512174606,
0.25818121433258057,
-0.2367139756679535,
0.3491981029510498,
-0.3672547936439514,
-0.05240966007113457,
-0.19971486926078796,
-0.08925508707761765,
0.35152122378349304,
0.32493409514427185,
-0.5481009483337402,
-0.961132287979126,
-0.4751332700252533,
0.8847537040710449,
0.6146517395973206,
0.6703400611877441,
0.2832536995410919,
-0.2675338387489319,
-0.09287528693675995,
0.27550259232521057,
-0.28735387325286865,
-0.06960494816303253,
0.7473198771476746,
-0.2878280580043793,
-0.38347113132476807,
-0.43238839507102966,
0.011473570019006729,
0.5227274298667908,
-0.24771060049533844,
-0.12153800576925278,
-0.2986164689064026,
0.1391621083021164,
-0.4019586443901062,
-0.5688163638114929,
0.015349788591265678,
-0.07360079884529114,
0.032014962285757065,
0.03139901161193848,
-0.11297855526208878,
0.09604214131832123,
0.2654016315937042,
-0.47371721267700195,
0.35839927196502686,
0.46935972571372986,
-0.5654668807983398,
0.480125367641449,
0.5093548893928528,
-0.22737498581409454,
-0.18897634744644165,
0.1632692664861679,
0.05665796995162964,
-0.35561197996139526,
0.11964748799800873,
-6.037659645080566,
0.4103473126888275,
-0.04315841197967529,
-0.20230798423290253,
-0.35093972086906433,
-0.01576789654791355,
1.0740476846694946,
0.08732561022043228,
0.07087739557027817,
-0.28767138719558716,
0.24463188648223877,
0.32853925228118896,
-0.025174563750624657,
0.20200733840465546,
0.04143963381648064,
0.20171299576759338,
0.270007461309433,
-0.19428454339504242,
0.4098053574562073,
0.5721993446350098,
-0.18059466779232025,
-0.027627738192677498,
-0.017143910750746727,
0.25874683260917664,
0.5772809982299805,
0.3806932866573334,
-0.9538252353668213,
0.05131581053137779,
-0.16917552053928375,
0.0019142236560583115,
0.2857351303100586,
-0.44356727600097656,
-0.13825514912605286,
-0.030661247670650482,
0.05753786489367485,
0.002494887448847294,
0.06461066752672195,
-0.3150066137313843,
0.009907059371471405,
-0.11094098538160324,
-0.03486914560198784,
0.4559799134731293,
-0.22438845038414001,
0.22567534446716309,
-0.20808587968349457,
-0.2601260840892792,
-0.07743183523416519,
-0.015089664608240128,
-0.10954016447067261,
1.0318899154663086,
-0.24564982950687408,
-0.07495435327291489,
0.13482244312763214,
0.3262157738208771,
0.14459683001041412,
-0.4713684916496277,
-0.09448905289173126,
0.267225444316864,
-0.4645879566669464,
0.42725107073783875,
0.11804519593715668,
-0.2853039503097534,
0.5924267768859863,
-0.6499939560890198,
0.0970655009150505,
0.002645613392814994,
-0.9556354880332947,
-0.45837047696113586,
-0.015367390587925911,
-0.19261977076530457,
-0.3523642122745514,
-0.17432035505771637,
-0.08756890892982483,
-0.8460882306098938,
-0.01268390379846096,
-0.14563427865505219,
-0.49222472310066223,
-0.029152031987905502,
0.651148796081543,
-0.4175850749015808,
-0.0956607237458229,
-0.11497685313224792,
-0.0058128610253334045,
0.11352366954088211,
-0.10979533195495605,
-0.4265700876712799,
0.15279652178287506,
-0.3271528482437134,
-0.2766900062561035,
-0.02126120962202549,
0.9322123527526855,
-0.43719860911369324,
0.3331710696220398,
0.19143062829971313,
0.07205235958099365,
0.7024547457695007,
0.4293535053730011,
-0.2546742260456085,
0.24100792407989502,
-0.06589134782552719,
0.9372433423995972,
-0.36852675676345825,
-0.39573773741722107,
-0.9563294053077698,
0.10110846161842346,
-0.21003589034080505,
0.07626725733280182,
0.35601815581321716,
0.8247156143188477,
-0.7349669933319092,
0.11175832897424698,
-0.0019323443993926048,
-0.6789125204086304,
-0.20644697546958923,
0.5725729465484619,
-0.3798905909061432,
0.2882383167743683,
-0.006195081863552332,
0.5818186402320862,
-0.16529221832752228,
0.28253331780433655,
0.5341803431510925,
-0.3532210886478424,
0.738361656665802,
0.6354402899742126,
-0.5493193864822388,
0.18567582964897156,
0.12516561150550842,
-0.46305370330810547,
-0.18746967613697052,
-0.232533261179924,
0.5390279293060303,
-0.0364086888730526,
0.0070250811986625195,
0.2342797964811325,
-0.0766335278749466,
-0.19959275424480438,
-0.59442538022995,
0.37958115339279175,
-0.20259468257427216,
0.12387654185295105,
0.055254288017749786,
-0.41108688712120056,
0.6804699301719666,
0.159013569355011,
0.16036048531532288,
0.02479477785527706,
0.0930427685379982,
-0.1802973747253418,
-0.36107441782951355,
0.11248422414064407,
0.3002961575984955,
0.5943950414657593,
0.20744310319423676,
-0.5103905200958252,
-0.10523734241724014,
0.3946995139122009,
0.39798954129219055,
-0.04444754123687744,
-0.36254066228866577,
0.4827127456665039,
-0.1144578829407692,
-0.9343910813331604,
0.08116823434829712,
0.288021445274353,
-0.604342520236969,
0.1859254390001297,
-0.5939385890960693,
-0.07935182750225067,
0.2646939158439636,
0.04251065477728844,
-0.35697534680366516,
0.043429553508758545,
0.09702146798372269,
-0.27887386083602905,
-0.36305177211761475,
-0.5709805488586426,
0.059124354273080826,
-0.2639123797416687,
-0.21485723555088043,
0.14754559099674225,
-0.11559383571147919,
-0.42497381567955017,
0.5938981771469116,
0.7986341714859009,
0.6056841015815735,
0.023518308997154236,
-0.291189581155777,
-0.011281408369541168,
-0.28407666087150574,
0.38584163784980774,
0.08945035934448242,
0.047941904515028,
0.35682979226112366,
-0.17253059148788452,
0.17044946551322937,
0.06090743839740753,
-0.03840397298336029,
-0.11095243692398071,
-0.11895116418600082,
-0.08788327872753143,
0.5519974827766418,
-0.37600013613700867,
0.4180919826030731,
0.1172327920794487,
0.01300131343305111,
0.4745044410228729,
-0.088306725025177,
-0.07908818870782852,
-0.591834545135498,
-0.0819527879357338,
-0.21200212836265564,
-0.10178156942129135,
0.335080623626709,
-0.6565840840339661,
-0.021741846576333046,
-0.20203281939029694,
-0.21586447954177856,
-0.2936747968196869,
0.11574872583150864,
0.2023746520280838,
-0.3255934715270996,
-0.053686849772930145,
-0.354269415140152,
-0.2156669795513153,
0.525597333908081,
1.0147429704666138,
-0.8570749163627625,
-0.06357800960540771,
0.4217190742492676,
-0.3882989287376404,
0.15198850631713867,
0.3339962959289551,
-0.11265404522418976,
-1.1774876117706299,
-0.0026342682540416718,
0.2204267531633377,
0.06598161906003952,
0.12474147975444794,
0.10804759711027145,
0.14403913915157318,
0.5779275894165039,
-0.15742623805999756,
-0.456869512796402,
0.19671863317489624,
-0.04494861513376236,
0.23058556020259857,
-0.8006340265274048,
-0.2748034596443176,
-0.18563131988048553,
-0.23810353875160217,
-0.12072035670280457,
0.09340501576662064,
0.07911968231201172,
0.1357804387807846,
0.2599043846130371,
-0.4797397553920746,
-0.0332394614815712,
0.24285872280597687,
0.31861168146133423,
-0.021372636780142784,
-0.781667172908783,
-0.2921726405620575,
-0.24900051951408386,
0.09284396469593048,
-0.5021954774856567,
-0.31001797318458557,
-0.198673814535141,
-0.06549125164747238,
-0.36976951360702515,
-0.13439828157424927,
-0.3176887631416321,
0.5970840454101562,
0.37993988394737244,
0.06181236729025841,
-0.09297536313533783,
-0.33177709579467773,
0.26337215304374695,
-0.6810756921768188,
0.1930789351463318,
-0.5646768808364868,
-0.7146642804145813,
0.17574486136436462,
-0.3315367102622986,
0.48036617040634155,
-0.01120821200311184,
0.15483805537223816,
0.237155482172966,
-0.10107631236314774,
-0.2775767147541046,
-0.03491933271288872,
-0.4440496563911438,
-0.23070144653320312,
-0.12818950414657593,
0.30290165543556213,
0.2196331024169922,
0.13506995141506195,
0.4345631003379822,
0.7063826322555542,
-0.05090600252151489,
-0.39542222023010254,
0.6544397473335266,
0.23612329363822937,
-0.6648337841033936,
0.4843299090862274,
-0.11415029317140579,
0.24722445011138916,
0.04874104633927345,
-0.07429062575101852,
0.4354858696460724,
0.24335989356040955,
0.2358013540506363,
-0.01287867221981287,
0.41111457347869873,
-0.5164731740951538,
0.3078749477863312,
-0.2382185161113739,
-0.8426122069358826,
0.5702736973762512,
0.017936252057552338,
0.08908931910991669,
0.5461958646774292,
0.4053748846054077,
0.06763850897550583,
-0.06669961661100388,
0.8650254607200623,
-0.39977267384529114,
0.40850621461868286,
0.26431238651275635,
-0.24658271670341492,
0.26317307353019714,
0.7698074579238892,
-0.2403542399406433,
0.23685476183891296,
0.11861126124858856,
0.4184383153915405,
0.2859994173049927,
-0.29548922181129456,
-0.03260212019085884,
0.01014131959527731,
0.49509260058403015,
0.23043645918369293,
-0.34994053840637207,
-0.35010775923728943,
-0.22575142979621887,
0.27958011627197266,
0.029947277158498764,
-0.013993765227496624,
-0.09393899887800217,
0.5534120798110962,
0.38562458753585815,
-0.2591180205345154,
-0.1718554049730301,
0.2637987732887268,
-0.14583885669708252,
0.1916801482439041,
-0.10507182031869888,
-0.3570587635040283,
-0.763594925403595,
0.3190402686595917,
0.4237699508666992,
-0.09433087706565857,
0.09752233326435089,
0.3514918386936188,
-0.19663135707378387,
0.3887023329734802,
0.4226921796798706,
0.1802201271057129,
0.08125618100166321,
-0.42251452803611755,
-0.10237380117177963,
-0.5547062158584595,
-0.31178563833236694,
0.10780417174100876,
0.30583301186561584,
-0.4830349385738373,
0.0033748627174645662,
0.06691321730613708,
-0.6524130702018738,
0.09314798563718796,
-0.37899473309516907,
0.20345847308635712,
-0.3132924735546112,
-0.25511473417282104,
0.2647581100463867,
0.15160508453845978,
-0.30062049627304077,
0.051749613136053085,
-0.1457682102918625,
0.17323380708694458,
0.033913787454366684,
-0.5922213196754456,
-0.0883684754371643,
0.04062626138329506,
-0.24095840752124786,
0.09643417596817017,
-0.15229226648807526,
0.6498399972915649,
0.1994124799966812,
-0.03874991089105606,
0.058168474584817886,
-0.10242404043674469,
-0.3206043541431427,
0.24758857488632202,
-0.03464670106768608,
0.3018176257610321,
-0.6835871934890747,
-0.5214731097221375,
-0.6397122740745544,
0.06286150217056274,
0.5023905634880066,
0.19156388938426971,
-0.2790265381336212,
-0.20909231901168823,
0.19437210261821747,
0.08790255337953568,
0.3528381288051605,
-0.4304652512073517,
-0.29299449920654297,
-0.47255921363830566,
-0.14370416104793549,
-0.8708393573760986,
0.28957533836364746,
0.17486773431301117,
0.05630126968026161,
-0.6072393655776978,
0.1870410442352295,
0.30207595229148865,
-0.591840922832489,
0.49000850319862366,
-0.0858541801571846,
-0.1658485382795334,
-0.6902125477790833,
0.42079243063926697,
-0.629627525806427,
-0.29176002740859985,
0.6170584559440613,
0.3778674006462097,
0.30416104197502136,
0.1016756072640419,
0.310874342918396,
-0.4996143579483032,
0.1664336621761322,
0.3465712070465088,
0.150337353348732,
0.34719517827033997,
-0.04726402461528778,
-0.14490851759910583,
-0.5232313275337219,
0.129539355635643,
-0.18858003616333008,
-0.04948387295007706,
-0.23372212052345276,
-0.06803594529628754,
-0.43354880809783936,
0.11173563450574875,
0.4447479844093323,
-0.30203777551651,
0.2667563855648041,
-0.0559239462018013
] |
We describe a Multiplex Primer Prediction (MPP) algorithm to build multiplex compatible primer sets to amplify all members of large, diverse and unalignable sets of target sequences. The MPP algorithm is scalable to larger target sets than other available software, and it does not require a multiple sequence alignment. We applied it to questions in viral detection, and demonstrated that there are no universally conserved priming sequences among viruses and that it could require an unfeasibly large number of primers (∼3700 18-mers or ∼2000 10-mers) to generate amplicons from all sequenced viruses. We then designed primer sets separately for each viral family, and for several diverse species such as foot-and-mouth disease virus (FMDV), hemagglutinin (HA) and neuraminidase (NA) segments of influenza A virus, Norwalk virus, and HIV-1. We empirically demonstrated the application of the software with a multiplex set of 16 short (10 nt) primers designed to amplify the Poxviridae family to produce a specific amplicon from vaccinia virus. | [
0.002832024823874235,
0.013117886148393154,
0.0011295414296910167,
0.010857230052351952,
-0.004771060310304165,
0.004858008585870266,
0.007549998816102743,
-0.01123720221221447,
-0.0069346195086836815,
-0.00826018862426281,
-0.008385898545384407,
0.01461758092045784,
0.008995910175144672,
0.011680458672344685,
0.0012946105562150478,
-0.0011606540065258741,
-0.009750365279614925,
0.007223806343972683,
0.0054753609001636505,
0.004570072516798973,
-0.0014971471391618252,
0.009996725246310234,
0.008529392071068287,
0.010328270494937897,
0.0042670960538089275,
0.012157924473285675,
-0.017081942409276962,
0.010410448536276817,
0.003953424748033285,
0.006911266129463911,
0.006651419214904308,
0.010487775318324566,
0.005536759737879038,
0.00728687085211277,
0.0014678470324724913,
-0.0024851735215634108,
0.00000843231100589037,
0.014335284009575844,
0.01714610680937767,
-0.004202160984277725,
0.0026105432771146297,
-0.007431318983435631,
-0.001838387455791235,
-0.02455674484372139,
-0.00497953686863184,
0.012902945280075073,
-0.0042763398960232735,
-0.004382229410111904,
-0.008851172402501106,
0.010489976033568382,
-0.0076092625968158245,
-0.0010147732682526112,
-0.011307666078209877,
-0.013539236038923264,
-0.004726911894977093,
-0.02823314070701599,
0.014080512337386608,
-0.015971191227436066,
0.008405355736613274,
-0.033222950994968414,
-0.014614434912800789,
0.0013974292669445276,
0.0041852728463709354,
-0.035454969853162766,
-0.05451149865984917,
-0.06788179278373718,
-0.002212046179920435,
-0.0038625760935246944,
-0.011465993709862232,
0.043332356959581375,
0.014282295480370522,
0.012684253975749016,
-0.016049522906541824,
-0.0007552236784249544,
0.02464311011135578,
-0.006725531071424484,
-0.012348659336566925,
0.013418281450867653,
-0.004481072071939707,
-0.0007175105856731534,
-0.028247902169823647,
-0.00844939611852169,
0.0009921202436089516,
0.004625561181455851,
-0.007345749530941248,
-0.0031933123245835304,
-0.0060097756795585155,
0.022185252979397774,
-0.013055479153990746,
0.017762087285518646,
0.01944224163889885,
-0.01349705085158348,
-0.019701633602380753,
-0.0006934806588105857,
-0.012774340808391571,
-0.005878605879843235,
-0.007980743423104286,
0.01769183948636055,
-0.024818001314997673,
0.025859732180833817,
-0.007296554744243622,
0.00023834907915443182,
0.013796653598546982,
-0.0072840070351958275,
0.016581619158387184,
0.008571851998567581,
0.002446100814267993,
0.020973799750208855,
0.011700539849698544,
0.002420639619231224,
-0.00263309758156538,
0.014129601418972015,
-0.03596949949860573,
-0.004756396170705557,
-0.012868679128587246,
0.01111777313053608,
0.015462715178728104,
0.01789039745926857,
0.014082017354667187,
0.04819273203611374,
0.004108231049031019,
0.0036592737305909395,
0.005963874980807304,
0.019730035215616226,
0.00802555587142706,
-0.004249136429280043,
0.011793946847319603,
0.004775082692503929,
0.010929192416369915,
0.000591323128901422,
-0.00931774266064167,
0.005018073134124279,
-0.009519558399915695,
0.004138079937547445,
0.025240564718842506,
0.0021231782156974077,
-0.0009935218840837479,
-0.02328084595501423,
0.0016914574662223458,
0.009053930640220642,
-0.0029368815012276173,
0.009820847772061825,
-0.00014955998631194234,
0.013267767615616322,
0.0034665437415242195,
0.001193144591525197,
0.0024323826655745506,
0.008065072819590569,
-0.012024606578052044,
-0.0033681916538625956,
0.004830877296626568,
-0.012000828981399536,
-0.01553923450410366,
-0.017842121422290802,
0.02011764608323574,
0.006857573054730892,
-0.004318228457123041,
-0.00978725217282772,
-0.014940321445465088,
-0.001871042768470943,
0.0118331890553236,
-0.007286325097084045,
-0.003286924446001649,
0.00751976715400815,
0.02807873860001564,
-0.016500044614076614,
-0.009005410596728325,
-0.012409153394401073,
-0.010885925963521004,
0.001155788660980761,
-0.00256527541205287,
0.01703667640686035,
-0.003060440067201853,
0.002953969407826662,
-0.0003361436538398266,
-0.0025351771619170904,
0.0016976404003798962,
0.005677676293998957,
-0.008725995197892189,
0.06751330196857452,
0.017928890883922577,
-0.012016482651233673,
-0.01791132241487503,
-0.006778935436159372,
0.010121766477823257,
-0.03053644858300686,
-0.0007052519358694553,
-0.01142346952110529,
0.0009047931525856256,
-0.000266900984570384,
-0.006846188567578793,
-0.029455531388521194,
-0.006236522924154997,
0.016000404953956604,
0.009638656862080097,
0.0038370941765606403,
-0.015559131279587746,
-0.0026648156344890594,
-0.003119892440736294,
-0.009449250064790249,
0.0018635322339832783,
-0.0031499869655817747,
0.001003932673484087,
0.011584488674998283,
0.015156487002968788,
0.008628934621810913,
-0.006821549963206053,
-0.010014061816036701,
-0.005103857256472111,
0.01594109833240509,
0.007283422630280256,
-0.0072527071461081505,
-0.009135468862950802,
-0.013458319008350372,
-0.0027131917886435986,
-0.008230498991906643,
0.00305839441716671,
-0.02093476615846157,
0.0008717607124708593,
-0.008958243764936924,
-0.0017356328899040818,
0.006830323021858931,
-0.0025504077784717083,
-0.01620563492178917,
0.02390326000750065,
0.006006191484630108,
0.0028479844331741333,
0.008207198232412338,
0.016978515312075615,
-0.009511717595160007,
0.003729709889739752,
0.002159068128094077,
-0.009375850670039654,
0.0016574626788496971,
0.005657586269080639,
0.010523993521928787,
0.008095944300293922,
-0.013067103922367096,
0.006853840313851833,
-0.014758532866835594,
-0.006627457682043314,
0.0035175865050405264,
0.00680126529186964,
-0.030457787215709686,
-0.002577555598691106,
-0.0005684420466423035,
0.02526860311627388,
0.002129791770130396,
0.012548444792628288,
-0.012389121577143669,
0.00496665108948946,
0.010094640776515007,
0.01159138884395361,
-0.010606881231069565,
0.0005942526622675359,
0.012680279091000557,
-0.02654709294438362,
0.026436062529683113,
0.021222388371825218,
-0.017566200345754623,
0.008267066441476345,
0.0050319479778409,
0.0067376140505075455,
-0.024728069081902504,
0.011346390470862389,
0.02299068495631218,
-0.0005534631200134754,
-0.019349053502082825,
-0.016384661197662354,
0.006458313670009375,
0.001646028133109212,
-0.0056647565215826035,
-0.006491091102361679,
-0.08186838030815125,
-0.004304434172809124,
-0.01918366365134716,
-0.00401271739974618,
0.008135377429425716,
-0.0123177170753479,
0.003052219981327653,
-0.003684496507048607,
-0.017172325402498245,
-0.0012315670028328896,
0.0015428290935233235,
0.0004837078449781984,
-0.011075682938098907,
0.015627143904566765,
-0.013490630313754082,
-0.001421601977199316,
0.012810868211090565,
0.016369223594665527,
0.0013171412283554673,
-0.028759397566318512,
0.018296025693416595,
-0.0017216834239661694,
0.007874452508985996,
-0.0046103596687316895,
-0.05044599622488022,
-0.006787354592233896,
0.004902218468487263,
0.02010251022875309,
0.012773113325238228,
-0.0007498509949073195,
-0.01587427780032158,
-0.016836203634738922,
0.010660985484719276,
-0.026712022721767426,
-0.014981339685618877,
-0.011417550966143608,
-0.0047818198800086975,
-0.001079418696463108,
-0.02259949781000614,
0.02731293812394142,
-0.002550310455262661,
0.001753099262714386,
-0.004477265756577253,
0.0006551432888954878,
0.002823053626343608,
0.023162556812167168,
0.008629591204226017,
0.014100300148129463,
0.012095802463591099,
-0.00960335973650217,
0.030756330117583275,
-0.0067193591967225075,
-0.018617922440171242,
0.012735259719192982,
-0.0012658389750868082,
-0.006154344417154789,
0.007440484128892422,
0.010491514578461647,
-0.015236007049679756,
-0.010766049847006798,
-0.02327008917927742,
0.0009512826800346375,
0.012093804776668549,
0.010285023599863052,
-0.01653916947543621,
0.009407004341483116,
0.013726799748837948,
-0.007626531179994345,
-0.003414878388866782,
-0.006617764011025429,
0.019099734723567963,
0.024595603346824646,
-0.005059621296823025,
0.0022224460262805223,
0.021807685494422913,
-0.011213989928364754,
-0.007817501202225685,
-0.01800401322543621,
0.003917437978088856,
-0.021939411759376526,
-0.030815571546554565,
0.010046541690826416,
0.01637026108801365,
-0.00022062205243855715,
-0.0142518924549222,
0.02443072199821472,
0.004099583253264427,
-0.002408362925052643,
0.0024668059777468443,
-0.006461083889007568,
-0.02826465293765068,
0.006842329166829586,
-0.0486239418387413,
0.006566239520907402,
-0.01573387160897255,
-0.008580837398767471,
-0.006763377692550421,
0.0057143159210681915,
0.016790475696325302,
0.008187673054635525,
0.023874951526522636,
-0.0021968844812363386,
-0.015728900209069252,
-0.012389147654175758,
-0.012467927299439907,
0.008867934346199036,
-0.0018983425106853247,
-0.015300627797842026,
-0.021259833127260208,
-0.001661111367866397,
-0.01870419643819332,
0.013067093677818775,
-0.007647027261555195,
0.028712887316942215,
0.0093684708699584,
-0.01102151907980442,
0.0027895295061171055,
0.013160254806280136,
0.07347920536994934,
-0.0010098125785589218,
-0.0037924754433333874,
-0.008558712899684906,
-0.013053064234554768,
-0.02855341136455536,
-0.022635284811258316,
0.02341405302286148,
0.022032879292964935,
0.018508534878492355,
0.009588886052370071,
-0.014438973739743233,
-0.0005806460976600647,
-0.016927454620599747,
-0.009779682382941246,
-0.0007937552873045206,
0.001621863804757595,
-0.011239264160394669,
0.011196181178092957,
0.008385684341192245,
0.008782356977462769,
-0.036763694137334824,
0.004195029381662607,
-0.0023401863873004913,
-0.008102510124444962,
-0.02246648445725441,
-0.002524302341043949,
-0.015046683140099049,
-0.0034391507506370544,
0.009444319643080235,
0.008146768435835838,
-0.016362488269805908,
-0.006308162584900856,
-0.003986999858170748,
-0.014652799814939499,
0.007098119705915451,
-0.006401410326361656,
0.009026437997817993,
-0.020512206479907036,
0.005742860492318869,
-0.004001027904450893,
-0.017893634736537933,
0.015510231256484985,
0.011411333456635475,
-0.021210938692092896,
0.0018073394894599915,
-0.010772782377898693,
-0.006210519000887871,
-0.005589710082858801,
0.007884969003498554,
-0.011302808299660683,
0.0008340714266523719,
0.010870099067687988,
0.03847241401672363,
-0.004266154021024704,
0.006074376404285431,
0.004897358827292919,
-0.006340088322758675,
0.010324157774448395,
-0.011562434956431389,
-0.005603922065347433,
-0.011498885229229927,
0.0022236942313611507,
-0.0017304178327322006,
-0.00936920940876007,
-0.018733223900198936,
0.012017685920000076,
-0.008054008707404137,
0.011164456605911255,
-0.02490111067891121,
0.0011535470839589834,
0.003915842622518539,
-0.01727747917175293,
-0.005734623409807682,
-0.003734786529093981,
-0.01779910735785961,
-0.0023571252822875977,
-0.021093368530273438,
-0.019032517448067665,
-0.006889279931783676,
0.013289366848766804,
0.009470279328525066,
-0.007418356835842133,
-0.012794570997357368,
0.0022180555388331413,
0.03347373008728027,
-0.026687337085604668,
-0.07545438408851624,
0.008406801149249077,
0.004827756434679031,
-0.004466241225600243,
-0.008830149658024311,
0.012055243365466595,
-0.0072122253477573395,
-0.008560162037611008,
0.018679410219192505,
-0.004360654391348362,
0.025928761810064316,
-0.014895018190145493,
-0.009882261976599693,
-0.011242594569921494,
0.008354244753718376,
0.016841402277350426,
-0.012704147025942802,
0.011871010065078735,
0.005877058021724224,
0.011477867141366005,
0.010203365236520767,
0.0035949498414993286,
-0.00817105732858181,
-0.004027722403407097,
-0.008475329726934433,
-0.08220957219600677,
-0.018544834107160568,
0.011732315644621849,
0.0032952704932540655,
-0.02344054915010929,
-0.0012676427140831947,
0.0036353785544633865,
-0.018306640908122063,
-0.01490399893373251,
-0.011045480147004128,
-0.01999836042523384,
-0.00849328376352787,
0.008597205393016338,
0.005408441182225943,
-0.003539356868714094,
-0.00558936782181263,
0.024210559204220772,
-0.002710889559239149,
0.0004904335364699364,
0.0006909603253006935,
-0.004028415307402611,
0.010862777009606361,
-0.007402911316603422,
-0.011188835836946964,
-0.014300825074315071,
-0.0018092202953994274,
-0.008806045167148113,
0.01253917533904314,
0.008254097774624825,
-0.019899047911167145,
-0.00818085577338934,
0.0015441380674019456,
-0.009646200574934483,
-0.015281395986676216,
-0.017486486583948135,
-0.0019682934507727623,
0.013234286569058895,
0.010540896095335484,
-0.011932789348065853,
-0.01564524881541729,
-0.002335562603548169,
0.03108443319797516,
0.0003397825639694929,
-0.0050993007607758045,
-0.015631167218089104,
0.0004271396901458502,
0.004492712672799826,
-0.0043678609654307365,
0.013216061517596245,
-0.0030180541798472404,
0.0061746141873300076,
-0.002307371934875846,
0.02149907499551773,
0.009789354167878628,
0.0002277784515172243,
0.018293866887688637,
-0.0035940322559326887,
0.019024932757019997,
0.01891198754310608,
0.014548718929290771,
0.0001939496723935008,
0.009368384256958961,
-0.008968573063611984,
0.07271093875169754,
-0.03237035125494003,
0.013739734888076782,
-0.032576028257608414,
-0.022492188960313797,
0.00229456415399909,
-0.007837415672838688,
0.026284843683242798,
0.023817960172891617,
-0.020688973367214203,
0.027460861951112747,
-0.008363856002688408,
-0.010466370731592178,
0.00583614781498909,
0.016019245609641075,
-0.0009640189819037914,
0.0025032460689544678,
0.003958284854888916,
0.006626507733017206,
0.01237737201154232,
-0.011997885070741177,
0.011915707029402256,
-0.021167468279600143,
0.014446770772337914,
0.009931374341249466,
-0.008716766722500324,
-0.0007526767440140247,
-0.0019144592806696892,
-0.0492369681596756,
-0.01820463500916958,
-0.010570099577307701,
0.015857908874750137,
0.0013208817690610886,
0.019797727465629578,
0.020792338997125626,
-0.011652669869363308,
0.011208653450012207,
0.0015451819635927677,
0.011060766875743866,
0.027308264747262,
-0.02389340288937092,
-0.008933416567742825,
-0.0038051013834774494,
-0.025710254907608032,
0.008037849329411983,
0.0017088813474401832,
0.023694247007369995,
0.031287506222724915,
0.02481355518102646,
-0.0027086439076811075,
-0.01733376458287239,
-0.0032851481810212135,
0.034960657358169556,
-0.0015367701416835189,
0.007772672921419144,
0.010664692148566246,
-0.020046863704919815,
0.0026840013451874256,
-0.00034453487023711205,
0.00582324992865324,
0.006674272008240223,
-0.008287547156214714,
0.00023036636412143707,
0.004425030201673508,
0.01061193086206913,
0.018500231206417084,
-0.0036962213926017284,
-0.014447085559368134,
0.015401722863316536,
0.012801151722669601,
-0.010757552459836006,
0.0077067152597010136,
0.004592000972479582,
-0.010400358587503433,
-0.003544894978404045,
0.018664412200450897,
-0.0025780079886317253,
0.010483091697096825,
0.012978903949260712,
0.0038162884302437305,
-0.013647269457578659,
-0.028787828981876373,
0.014772890135645866,
0.02247302606701851,
0.020519550889730453,
0.03239744156599045,
0.011320044286549091,
0.009924969635903835,
-0.004640767816454172,
0.005483411252498627,
0.032383233308792114,
0.005064497701823711,
0.003265694249421358,
-0.0033611757680773735,
0.006481444463133812,
0.032811909914016724,
-0.01113876886665821,
0.014208536595106125,
0.013256005942821503,
0.005987072363495827,
0.014738339930772781,
-0.002739841816946864,
-0.03207872807979584,
0.01985059306025505,
0.001961556961759925,
0.015025402419269085,
0.006715304218232632,
-0.011283104307949543,
0.009909059852361679,
0.01688176393508911,
0.013170171529054642,
0.009965630248188972,
-0.009670783765614033,
-0.0022421516478061676,
0.011754995211958885,
0.010764343664050102,
0.0017691263929009438,
0.02164355479180813,
0.008547063916921616,
-0.00598113052546978,
-0.02978014200925827,
-0.0045051914639770985,
-0.00454657431691885,
0.01182758528739214,
0.021293891593813896,
-0.01731863245368004,
-0.005619887728244066,
0.004936764016747475,
-0.005499112885445356,
0.008065328001976013,
0.023267867043614388,
-0.03512629494071007,
-0.021839844062924385,
0.027569103986024857,
0.015062304213643074,
0.002160583855584264,
0.01522873342037201,
-0.013011584058403969,
0.01179378293454647,
-0.01295286975800991,
0.028419895097613335,
-0.01588931865990162,
0.012967023067176342,
-0.0044087693095207214,
0.008532149717211723,
-0.012365494854748249,
0.008417601697146893,
0.007890107110142708,
0.00007479439955204725,
0.007718170061707497,
0.016652747988700867,
-0.008043571375310421,
0.005170009098947048,
-0.0063362037762999535,
0.008594240993261337,
0.009316405281424522,
0.0014938978711143136,
-0.024749424308538437,
-0.006063191685825586,
0.013177309185266495,
-0.01917794719338417,
0.025177378207445145,
-0.015427598729729652,
0.011951027438044548,
0.011080743744969368,
0.008946239948272705,
0.001736662583425641,
-0.0013920594938099384,
-0.009857675060629845,
0.005017289891839027,
0.0068176486529409885,
-0.0016024770447984338,
-0.011396502144634724,
0.023648254573345184,
-0.007918965071439743,
-0.007528909016400576,
-0.011024169623851776,
0.007766761817038059,
0.003697528038173914,
0.028128478676080704,
0.0034827347844839096,
-0.010882520116865635,
0.00002354942262172699,
-0.0072632101364433765,
-0.00437446404248476,
0.007092668674886227,
-0.007047457620501518,
-0.0019238311797380447,
0.0054170070216059685,
0.012687090784311295,
-0.008275355212390423,
0.0022530071437358856,
-0.020422793924808502,
-0.014032755047082901,
-0.006595995742827654,
-0.006795390974730253,
-0.004909802693873644,
-0.012087720446288586,
0.015275971964001656,
0.0018116303253918886,
0.016371069476008415,
-0.025635946542024612
] | [
0.12738530337810516,
-0.11099185794591904,
-0.10268335044384003,
0.178580179810524,
-0.009763623587787151,
0.43660324811935425,
0.01832125335931778,
-0.512596070766449,
-0.3141498863697052,
-0.34099242091178894,
0.29145240783691406,
-0.01463954895734787,
-0.7321813702583313,
0.03735065460205078,
0.2342168092727661,
0.5200619101524353,
0.2834774851799011,
0.1461295485496521,
-0.2092851847410202,
-0.34222960472106934,
-0.14890393614768982,
-0.07808637619018555,
0.38222771883010864,
-0.10873568058013916,
-0.1178639754652977,
0.04194177687168121,
0.6620424389839172,
0.03554209694266319,
0.00450029456987977,
-0.08499681949615479,
0.029110189527273178,
0.3948991000652313,
-0.05265836790204048,
-0.36359402537345886,
0.1678113043308258,
-0.26725199818611145,
0.11841344833374023,
0.719065248966217,
0.14720481634140015,
-0.17241492867469788,
0.15346919000148773,
-0.3202841877937317,
0.060143012553453445,
0.08619553595781326,
-0.3682670295238495,
-1.1044076681137085,
-1.4412764310836792,
0.17388413846492767,
-0.5056841969490051,
-0.20132945477962494,
-0.24582171440124512,
0.18929876387119293,
0.3281708359718323,
0.28146275877952576,
-0.035565827041864395,
0.34449905157089233,
-0.28866249322891235,
-0.36145493388175964,
0.6794343590736389,
-0.020531756803393364,
-0.22629770636558533,
-0.5031651258468628,
-0.27512863278388977,
0.07744637131690979,
-0.0690385177731514,
0.7470557689666748,
0.1420055627822876,
-0.25226864218711853,
-0.6088773608207703,
-0.11474927514791489,
0.34076571464538574,
-0.5652121305465698,
-0.39066481590270996,
0.32642412185668945,
-0.06331230700016022,
-0.1992485076189041,
-0.12645119428634644,
-0.009471187368035316,
0.45142510533332825,
0.37311792373657227,
-0.039787549525499344,
0.1704147607088089,
-0.01970077119767666,
-0.009539864026010036,
0.36716580390930176,
0.6535966396331787,
0.1602076143026352,
0.4064160883426666,
-0.6668589115142822,
-0.0997043177485466,
0.05162731558084488,
-0.279629111289978,
-0.175604447722435,
0.6252954602241516,
0.49547237157821655,
0.18140821158885956,
-0.24481576681137085,
-0.3881920278072357,
-0.0967995822429657,
0.7264517545700073,
-0.284208744764328,
-0.291605681180954,
0.275016725063324,
-0.26411953568458557,
-0.1949792206287384,
-0.46629786491394043,
-0.58404141664505,
-0.6009040474891663,
-0.6018388867378235,
-0.027090750634670258,
-0.4088602066040039,
0.7613639831542969,
0.2868097722530365,
-0.32715100049972534,
-0.4597938358783722,
-0.2449856847524643,
0.3475413918495178,
-0.35870957374572754,
-0.09578534960746765,
0.3853570520877838,
-0.35437437891960144,
1.628919005393982,
0.39537665247917175,
0.3915551006793976,
0.008522646501660347,
-0.006107314955443144,
0.5205938816070557,
0.4502635598182678,
-0.3421298861503601,
0.7882524132728577,
0.19808010756969452,
0.7656604051589966,
0.1264149248600006,
0.2542921304702759,
-0.23206540942192078,
-0.6033763289451599,
-0.15986312925815582,
0.027035819366574287,
0.009068986400961876,
-0.1875569075345993,
-0.50074303150177,
-0.5116402506828308,
0.1548316329717636,
0.031324613839387894,
0.13097035884857178,
-0.044366709887981415,
-0.4752127230167389,
-0.278359979391098,
-0.44019898772239685,
-0.1330920159816742,
-0.28646188974380493,
-0.008076736703515053,
-0.3242532014846802,
-0.24627572298049927,
-0.2471427172422409,
0.18945910036563873,
-0.09879251569509506,
-0.03109149821102619,
-0.31869110465049744,
0.4289272427558899,
0.3184013366699219,
0.35022419691085815,
-0.5450871586799622,
-0.4905186891555786,
0.05921744927763939,
-0.402281790971756,
0.5937252640724182,
0.8131580352783203,
0.052946787327528,
0.15789414942264557,
0.02263188548386097,
-0.16985972225666046,
0.13091930747032166,
-0.5033652186393738,
-0.31543096899986267,
-0.08675476163625717,
0.3291144371032715,
0.027046607807278633,
0.2551015615463257,
0.028331732377409935,
-0.6592565774917603,
-0.0714021772146225,
0.007388158701360226,
-0.4761795997619629,
0.15935863554477692,
0.24047410488128662,
0.808748185634613,
0.16374994814395905,
-0.1769530177116394,
-0.01998659037053585,
-0.4993308484554291,
-0.2722966969013214,
0.29544907808303833,
-0.9542815089225769,
1.1849569082260132,
-0.11020711064338684,
-0.23429366946220398,
1.0168395042419434,
0.43044784665107727,
0.16721898317337036,
-0.15418444573879242,
-0.08582029491662979,
0.35316604375839233,
-0.4319884181022644,
-0.6098695993423462,
0.0726066306233406,
0.026242520660161972,
0.08081233501434326,
-0.5346120595932007,
0.20610836148262024,
0.46796363592147827,
0.17882639169692993,
-0.17667344212532043,
-0.4439334571361542,
-0.06918533891439438,
0.30294108390808105,
-0.10201610624790192,
0.16853846609592438,
-0.1750931590795517,
0.10629505664110184,
0.6682242155075073,
-0.7353646159172058,
0.1958983987569809,
0.4652251899242401,
0.09322728961706161,
0.7707561254501343,
0.6022617220878601,
0.2884553074836731,
0.8988629579544067,
-0.37727463245391846,
0.2200741022825241,
-0.5786108374595642,
0.2494935244321823,
-0.4095706343650818,
-0.06343909353017807,
-0.06654923409223557,
0.061990633606910706,
0.025680799037218094,
0.35900625586509705,
0.02732822299003601,
-0.1000075414776802,
0.5498486161231995,
-0.565483808517456,
-0.25693395733833313,
0.11972268670797348,
-0.5616798996925354,
-0.44653254747390747,
-0.1930672526359558,
-0.20995619893074036,
-0.16930240392684937,
-0.1042589545249939,
0.08261694014072418,
0.32484468817710876,
-0.4132463335990906,
0.22824247181415558,
0.38598865270614624,
0.05459296703338623,
-0.22374413907527924,
0.2782280445098877,
-0.1459638476371765,
-0.36654624342918396,
-0.037099555134773254,
0.3762335479259491,
-0.0841328427195549,
0.04804376885294914,
-0.25504711270332336,
-0.34295251965522766,
-0.3778747320175171,
0.8131094574928284,
0.930772602558136,
0.5361776351928711,
0.056689079850912094,
-0.3868626058101654,
-0.049532201141119,
0.25737711787223816,
-0.9798508286476135,
0.27173492312431335,
0.6609553694725037,
-0.6477188467979431,
-0.8052398562431335,
-0.07553349435329437,
0.238739013671875,
0.5394027829170227,
-0.14730529487133026,
-0.31732940673828125,
-0.21960753202438354,
0.010936631821095943,
0.020035238936543465,
-0.3086381256580353,
0.02625071443617344,
-0.302304744720459,
0.27225837111473083,
-0.5834127068519592,
-0.4658430218696594,
0.543927013874054,
0.5083655714988708,
0.1685352623462677,
0.00228560296818614,
0.6476953029632568,
-0.06455596536397934,
-0.28701531887054443,
0.09004105627536774,
0.020068839192390442,
-0.4017714262008667,
-0.00764470687136054,
0.018696649000048637,
-0.09276682138442993,
0.5281403064727783,
-6.006831169128418,
-0.29755234718322754,
-0.8590520024299622,
-0.09439205378293991,
-0.4393256902694702,
0.1426725536584854,
0.8042768239974976,
-0.1851249635219574,
0.22882913053035736,
-0.1852807253599167,
0.012113879434764385,
0.0693802759051323,
0.06148888170719147,
0.05678839236497879,
0.45445629954338074,
-0.04893336445093155,
-0.06413555890321732,
0.42914608120918274,
0.7126591801643372,
0.2901698350906372,
0.4338900148868561,
-0.48540008068084717,
0.08819042146205902,
0.1863904893398285,
0.3863087296485901,
0.14322274923324585,
-0.8850235342979431,
0.4063451290130615,
-0.055111613124608994,
-0.33937546610832214,
-0.033069197088479996,
-0.553473174571991,
-0.19411295652389526,
-0.7483029365539551,
0.0723019689321518,
0.26988115906715393,
0.4524008631706238,
-0.10757263749837875,
0.17602311074733734,
-0.05844292417168617,
0.5948050022125244,
0.21392042934894562,
0.09923660755157471,
-0.5670756101608276,
-0.1483314484357834,
-0.04674845561385155,
-0.06454679369926453,
0.1530555635690689,
0.057169754058122635,
0.4927981197834015,
0.025553559884428978,
0.07165572047233582,
0.23268386721611023,
0.4234461188316345,
-0.19748654961585999,
-0.2524089813232422,
0.21563312411308289,
0.09982793778181076,
0.02423785999417305,
-0.23011094331741333,
0.584069550037384,
-0.39627519249916077,
-0.05255648493766785,
-0.5941336750984192,
-0.3220597803592682,
0.09687328338623047,
-0.158843994140625,
-0.17767909169197083,
0.38185831904411316,
0.267055481672287,
-0.4536338150501251,
-0.681777834892273,
0.04733962193131447,
-0.3759460747241974,
0.36131492257118225,
-0.07768410444259644,
0.1551172137260437,
-0.0094955675303936,
-0.5047774910926819,
0.16401758790016174,
-0.36132413148880005,
-0.7542818188667297,
0.1627766489982605,
-0.11502078175544739,
0.4274083077907562,
-0.5294127464294434,
-0.6786009669303894,
-0.23485051095485687,
-0.3018980622291565,
0.34291282296180725,
0.2083117812871933,
-0.5033091306686401,
0.30443817377090454,
0.12700437009334564,
0.6712104678153992,
0.11048900336027145,
0.5965395569801331,
0.22779113054275513,
0.5016242265701294,
-0.14454030990600586,
0.13473725318908691,
-0.0025727148167788982,
-0.4374221861362457,
-0.7014973163604736,
0.07856936007738113,
0.14290925860404968,
-0.5872770547866821,
0.059338461607694626,
0.28470349311828613,
-0.29237520694732666,
-0.2000621110200882,
-0.003797100391238928,
-0.013551326468586922,
0.07690182328224182,
0.37825316190719604,
-0.05602971091866493,
0.2778395116329193,
-0.17932595312595367,
0.49724432826042175,
-0.3369077444076538,
-0.16797472536563873,
0.388460248708725,
-0.16314640641212463,
0.3909206986427307,
0.0810767188668251,
-0.5921867489814758,
0.3108607232570648,
0.694220244884491,
-0.43621885776519775,
-0.3294358551502228,
0.49335506558418274,
-0.038842350244522095,
-0.5491792559623718,
0.06562434881925583,
0.4490431249141693,
-0.1909511536359787,
0.038048360496759415,
0.11364144086837769,
0.5183455348014832,
-0.30942270159721375,
0.41726434230804443,
-0.510835587978363,
0.022939195856451988,
0.289424866437912,
0.018852220848202705,
0.3391796946525574,
0.6115701198577881,
-0.004207880701869726,
-0.37666213512420654,
-0.20905734598636627,
-0.24688583612442017,
-0.3052639961242676,
0.5160715579986572,
-0.3203381896018982,
-0.08986446261405945,
0.39863121509552,
0.44701701402664185,
0.03397616371512413,
0.2211727350950241,
-0.5137718319892883,
0.4512677490711212,
0.18948909640312195,
-1.0389397144317627,
-0.08996935188770294,
-0.16046425700187683,
0.25507768988609314,
-0.432418555021286,
0.3619309961795807,
-0.1636229008436203,
0.24860942363739014,
-0.33337005972862244,
-0.33441004157066345,
0.08352816849946976,
0.022343648597598076,
0.10764927417039871,
-0.08211079984903336,
0.305526465177536,
0.2761039137840271,
-0.4167696237564087,
0.22532375156879425,
-0.06927230954170227,
-0.42175328731536865,
0.061240073293447495,
0.6204541921615601,
0.5890829563140869,
0.46238961815834045,
-0.2169647067785263,
-0.2909488379955292,
-0.7675071358680725,
-0.5830838680267334,
-0.3582761883735657,
0.29406943917274475,
0.571129322052002,
-0.4217536449432373,
0.024143019691109657,
-0.4974615275859833,
-0.08388662338256836,
0.06502457708120346,
-0.022401656955480576,
-0.32309165596961975,
-0.02206486463546753,
0.44559937715530396,
-0.37306660413742065,
0.5477665066719055,
0.43713560700416565,
-0.11877962201833725,
-0.08270899206399918,
-0.12699927389621735,
0.15159080922603607,
-0.13207893073558807,
-0.16274039447307587,
-0.431084543466568,
-0.024794988334178925,
0.3904597759246826,
-0.39288944005966187,
0.12805525958538055,
0.5730022192001343,
0.11436330527067184,
0.03231717273592949,
-0.07548141479492188,
0.45659396052360535,
-0.5921624302864075,
-0.04040638729929924,
0.016707241535186768,
-0.4735211431980133,
0.3980177938938141,
0.4375995099544525,
-0.643610417842865,
-0.18296870589256287,
0.40550485253334045,
-0.08254596590995789,
-0.4110899865627289,
0.057000402361154556,
0.2416446954011917,
-0.6464667320251465,
-0.3642309606075287,
-0.736042857170105,
0.06908109784126282,
-0.3097289204597473,
-0.0032944469712674618,
0.31299859285354614,
0.46218162775039673,
-0.24145245552062988,
-0.041380494832992554,
-0.6873838901519775,
0.43116721510887146,
0.49224671721458435,
-0.4003014862537384,
-0.566777229309082,
0.08086233586072922,
-0.1801285445690155,
-0.06883888691663742,
-0.022156918421387672,
0.19710442423820496,
0.7801417112350464,
0.4656434953212738,
-0.4244227409362793,
-0.5658491253852844,
-0.17344020307064056,
0.4293183982372284,
0.08625918626785278,
-0.27078670263290405,
-0.6208497881889343,
-0.3135538399219513,
0.3534424304962158,
0.10537348687648773,
-0.01307947002351284,
-0.5525384545326233,
0.3105321228504181,
-0.1616792529821396,
-0.5215305089950562,
0.0333348847925663,
-0.01901857741177082,
0.6898375749588013,
-0.1815773844718933,
-0.03946864232420921,
0.03338369354605675,
0.2648824155330658,
-0.13714098930358887,
0.08118144422769547,
-0.13845980167388916,
-0.37212735414505005,
0.27104735374450684,
-0.2540322244167328,
0.0004618571256287396,
-0.2836013734340668,
-0.0008917145314626396,
-0.3168821632862091,
0.12610481679439545,
-0.1383175551891327,
-0.35212746262550354,
0.40403956174850464,
-0.8659037947654724,
-0.03060944564640522,
-0.09641486406326294,
0.2632646858692169,
0.5213146805763245,
0.2199447900056839,
-0.008999355137348175,
-0.48136913776397705,
-0.15129594504833221,
0.37916451692581177,
0.7155479192733765,
-0.8043875694274902,
0.14309142529964447,
-0.07595539838075638,
0.3023765981197357,
0.3251050114631653,
-0.08419129252433777,
-0.06999888271093369,
0.1848297268152237,
0.23973989486694336,
0.37139299511909485,
0.19807085394859314,
-0.22397105395793915,
-0.05451403930783272,
0.09117131680250168,
-0.07661035656929016,
0.5126743316650391,
0.22013556957244873,
0.4698454737663269,
0.216938316822052,
0.5613909959793091,
-0.4156220257282257,
-0.833274781703949,
0.48242661356925964,
-0.03638729825615883,
0.05205212160944939,
-0.03272378072142601,
0.14947478473186493,
0.5391051173210144,
0.5070530772209167,
-0.7858123779296875,
0.24479076266288757,
0.09888024628162384,
-0.022340619936585426,
-0.4130430519580841,
0.014238514937460423,
-0.0300365649163723,
-0.09166637063026428,
0.6223331093788147,
0.5966187715530396,
-0.3247354030609131,
0.18369169533252716,
0.3363127112388611,
-0.11307118088006973,
0.4093552231788635,
0.25038981437683105,
-0.10135287046432495,
0.47478318214416504,
-0.07646215707063675,
-0.03040142171084881,
-0.09270230680704117,
0.20571961998939514,
-0.20523203909397125,
-0.2219715565443039,
0.5335180163383484,
-0.40868714451789856,
0.051207222044467926,
0.5446689128875732,
0.22201868891716003,
0.6767613291740417,
-0.39773744344711304,
0.42797940969467163,
-0.413891077041626,
0.0666152834892273,
0.4945816397666931,
0.2768549621105194,
0.2449391484260559,
-0.07673337310552597,
0.11162229627370834,
0.15681126713752747,
-0.11849803477525711,
0.7172330617904663,
-0.5188272595405579,
-0.13690727949142456,
-0.21174192428588867,
-0.042168956249952316,
-0.09886422753334045,
0.25876399874687195,
0.10820998251438141,
0.01409614272415638,
0.007524413987994194,
-0.28029686212539673,
0.17557595670223236,
-0.08511189371347427,
0.07070013880729675,
-0.14325524866580963,
0.2936192452907562,
0.14757540822029114,
0.2523922324180603,
-1.1823174953460693,
-0.1887931227684021,
-0.061315685510635376,
0.15793165564537048,
-0.08196394145488739,
-0.2899637520313263,
0.7547958493232727,
0.5104560852050781,
0.23489342629909515,
0.09028034657239914,
0.2045491337776184,
0.2933533191680908,
0.6505125761032104,
-0.3063631057739258,
0.1887754201889038,
-0.4565482437610626,
-0.2828123867511749,
-0.7429884672164917,
-0.19633899629116058,
1.032612919807434,
0.17485074698925018,
-0.3195319175720215,
-0.16143682599067688,
-0.1952316164970398,
0.1073988825082779,
-0.1694125086069107,
-0.6283138394355774,
0.36296775937080383,
-0.2755568325519562,
-0.16780389845371246,
-0.4265967607498169,
0.5184369087219238,
0.14924569427967072,
-0.11124847084283829,
-0.2719195485115051,
0.5533192753791809,
0.09663967043161392,
-0.593965470790863,
0.4169565439224243,
-0.11285699903964996,
0.07508485019207001,
-0.18646329641342163,
0.38512617349624634,
-0.47480443120002747,
0.1365247219800949,
-0.11690311878919601,
0.5497891902923584,
0.02351078949868679,
-0.5938149690628052,
-0.43435660004615784,
0.0660850927233696,
0.08834850043058395,
0.2021266520023346,
0.22014546394348145,
0.49116480350494385,
0.002403238555416465,
-0.3069477379322052,
-1.0677242279052734,
0.33345693349838257,
0.018877118825912476,
-0.16892656683921814,
-0.1773354709148407,
-0.041363850235939026,
-0.35409480333328247,
0.32467612624168396,
0.19159989058971405,
-0.3669051229953766,
-0.24859723448753357,
-0.10476203262805939
] |
Activation of the type I interferon (IFN) pathway by small interfering RNA (siRNA) is a major contributor to the off-target effects of RNA interference in mammalian cells. While IFN induction complicates gene function studies, immunostimulation by siRNAs may be beneficial in certain therapeutic settings. Various forms of siRNA, meeting different compositional and structural requirements, have been reported to trigger IFN activation. The consensus is that intracellularly expressed short-hairpin RNAs (shRNAs) are less prone to IFN activation because they are not detected by the cell-surface receptors. In particular, lentiviral vector-mediated transduction of shRNAs has been reported to avoid IFN response. Here we identify a shRNA that potently activates the IFN pathway in human cells in a sequence- and 5′-triphosphate-dependent manner. In addition to suppressing its intended mRNA target, expression of the shRNA results in dimerization of interferon regulatory factor-3, activation of IFN promoters and secretion of biologically active IFNs into the extracellular medium. Delivery by lentiviral vector transduction did not avoid IFN activation by this and another, unrelated shRNA. We also demonstrated that retinoic-acid-inducible gene I, and not melanoma differentiation associated gene 5 or toll-like receptor 3, is the cytoplasmic sensor for intracellularly expressed shRNAs that trigger IFN activation. | [
-0.0032279614824801683,
0.005077742040157318,
-0.009977252222597599,
0.03458143398165703,
0.01617087796330452,
-0.00888807699084282,
0.014066794887185097,
0.033658601343631744,
-0.019434761255979538,
0.0005948093021288514,
-0.01783032901585102,
0.009368546307086945,
-0.030318981036543846,
0.0014451128663495183,
-0.017632121220231056,
-0.047060247510671616,
-0.005740360356867313,
0.013209827244281769,
0.007405898533761501,
0.023356465622782707,
0.011455433443188667,
0.01321833673864603,
0.01208413951098919,
-0.010305389761924744,
0.0371650755405426,
0.011774083599448204,
-0.001841716468334198,
-0.02986721880733967,
0.0010909440461546183,
-0.022218719124794006,
0.03147054463624954,
0.0026817037723958492,
0.009641999378800392,
0.0016852249391376972,
0.0047663310542702675,
-0.020887527614831924,
-0.006847469136118889,
0.030111927539110184,
0.041138384491205215,
-0.0032922495156526566,
-0.0019016539445146918,
-0.015001572668552399,
0.00489704729989171,
-0.00740037439391017,
-0.0036863302811980247,
-0.011503777466714382,
0.001994968857616186,
0.006772832944989204,
-0.017579037696123123,
0.00421211589127779,
0.0030250719282776117,
-0.01837877929210663,
-0.012969917617738247,
0.005256302654743195,
-0.0077249715104699135,
0.011601664125919342,
0.020529961213469505,
0.0015980922617018223,
-0.03221946954727173,
0.013454475440084934,
0.02392265945672989,
-0.002249885583296418,
0.0172276608645916,
-0.022968381643295288,
0.005755334161221981,
-0.06612744927406311,
0.007040042895823717,
-0.016320249065756798,
0.022424915805459023,
0.00921702105551958,
0.004615633748471737,
0.023273512721061707,
-0.018874991685152054,
-0.02615005150437355,
-0.03347371891140938,
-0.004585159942507744,
-0.005902222357690334,
0.008745766244828701,
0.005361281335353851,
-0.0019889543764293194,
0.014379307627677917,
0.004937794990837574,
0.014620864763855934,
0.00018014665693044662,
0.014829195104539394,
0.020986003801226616,
-0.020537206903100014,
-0.023149527609348297,
0.0017820580396801233,
0.008545733988285065,
-0.005711870733648539,
0.03426533564925194,
-0.0010208217427134514,
0.02070397324860096,
0.018370606005191803,
-0.02586580067873001,
-0.007018805481493473,
-0.045143984258174896,
0.00756287295371294,
-0.01251312717795372,
-0.04342270642518997,
-0.013171348720788956,
0.016119614243507385,
-0.003237855387851596,
-0.0038926517590880394,
0.012370079755783081,
0.024894680827856064,
0.028597913682460785,
-0.01427219994366169,
0.011734205298125744,
-0.015244737267494202,
-0.017123743891716003,
-0.000788375735282898,
0.005143404938280582,
-0.008495759218931198,
-0.022486310452222824,
-0.04173629730939865,
0.025352684780955315,
0.012719307094812393,
-0.0020796447061002254,
0.042026251554489136,
0.005366955883800983,
0.004439481999725103,
-0.0035164980217814445,
0.003885061712935567,
-0.007001938764005899,
-0.016145657747983932,
-0.001018764916807413,
-0.04478892683982849,
0.0034202018287032843,
-0.008209388703107834,
0.02774427831172943,
-0.024181939661502838,
0.0014698009472340345,
0.00264731515198946,
0.0020319309551268816,
0.03078375943005085,
0.00919794850051403,
-0.0053816926665604115,
-0.021359365433454514,
-0.029802722856402397,
0.012512005865573883,
0.0038449380081146955,
0.015363047830760479,
0.03530370444059372,
0.0018343640258535743,
-0.018749568611383438,
-0.0024614413268864155,
0.027847502380609512,
-0.01732417196035385,
-0.012726512737572193,
-0.0030182627961039543,
0.004852930083870888,
-0.00732007808983326,
-0.0036005894653499126,
0.015258797444403172,
-0.02402091771364212,
-0.023657439276576042,
-0.024477986618876457,
-0.019263863563537598,
0.010537750087678432,
-0.011994310654699802,
-0.002494016196578741,
0.010392011143267155,
-0.00330162001773715,
-0.022653942927718163,
0.019708363339304924,
-0.010579528287053108,
0.00933996494859457,
0.006219552829861641,
-0.022193703800439835,
0.009427262470126152,
0.004785459954291582,
0.007909610867500305,
-0.004735286347568035,
-0.007712502498179674,
-0.0136914923787117,
0.0069742584601044655,
-0.018693333491683006,
0.06566520035266876,
-0.011863443069159985,
-0.00404077535495162,
0.05286996811628342,
0.014118492603302002,
-0.013395112007856369,
-0.02968415431678295,
0.053470429033041,
-0.011821309104561806,
0.0007431890117004514,
0.04108591750264168,
-0.01317396480590105,
-0.03506079316139221,
-0.01883271336555481,
-0.006192255765199661,
-0.061764106154441833,
0.004505411721765995,
0.055327244102954865,
0.01258770003914833,
-0.010365208610892296,
0.004012591205537319,
0.033427294343709946,
0.005585293751209974,
0.05659244954586029,
0.012952295131981373,
-0.015484698116779327,
0.00422517629340291,
-0.01322463434189558,
-0.02627873234450817,
-0.026749268174171448,
-0.014931186102330685,
0.0070550087839365005,
0.0013285977765917778,
0.005026606842875481,
-0.04580499231815338,
0.048488013446331024,
0.016930267214775085,
-0.0019142309902235866,
0.04258670657873154,
-0.0018479519058018923,
-0.01725997030735016,
-0.001134124817326665,
0.014512242749333382,
0.022710692137479782,
-0.04638729244470596,
0.04215836524963379,
-0.01886778697371483,
0.012962844222784042,
0.017555123195052147,
-0.011459152214229107,
0.0024200279731303453,
-0.02609478309750557,
-0.023343779146671295,
-0.012999095022678375,
0.023151546716690063,
0.001428650226444006,
-0.008168221451342106,
0.012071186676621437,
0.005968085024505854,
0.031102806329727173,
-0.014981838874518871,
-0.007442459464073181,
-0.007046352606266737,
0.0206285547465086,
-0.022004222497344017,
-0.02409345470368862,
0.03196330741047859,
0.019990207627415657,
0.02352941781282425,
-0.007488975301384926,
-0.015646914020180702,
0.012554493732750416,
0.0016879418399184942,
-0.04449957609176636,
-0.02382681332528591,
0.009360472671687603,
-0.0054985336028039455,
0.007148557808250189,
0.0013739995192736387,
0.029759231954813004,
-0.00557118421420455,
0.010125107131898403,
0.0020832442678511143,
-0.007933160290122032,
-0.020070429891347885,
-0.017580939456820488,
0.03915967047214508,
-0.015292897820472717,
-0.033128343522548676,
0.027775585651397705,
-0.025883087888360023,
0.007441028021275997,
-0.011586705222725868,
-0.01834089308977127,
-0.08102050423622131,
0.0011857339413836598,
-0.015030614100396633,
0.00808135699480772,
0.011948199942708015,
-0.02498329058289528,
-0.015677304938435555,
0.02015681564807892,
-0.01872194930911064,
0.020400190725922585,
-0.005355756264179945,
0.02068636752665043,
-0.0035732188262045383,
0.0018114701379090548,
0.01869792491197586,
0.0040372805669903755,
0.010734816081821918,
0.036261528730392456,
-0.03796099126338959,
-0.013694677501916885,
-0.007798442617058754,
-0.05548515543341637,
-0.0017311503179371357,
-0.005093498155474663,
-0.01373402401804924,
0.03704183176159859,
-0.015606303699314594,
-0.018542658537626266,
-0.02059215120971203,
-0.01125715859234333,
-0.0022694049403071404,
-0.013025288470089436,
0.002447274513542652,
0.01043053437024355,
0.009276356548070908,
0.05472323298454285,
0.004135774914175272,
-0.015898557379841805,
-0.02537122182548046,
-0.044739872217178345,
-0.0017323647625744343,
0.011403566226363182,
0.017986953258514404,
0.009481159970164299,
0.01422528550028801,
0.013737596571445465,
0.014896989800035954,
0.05418848991394043,
0.01840011030435562,
-0.022788606584072113,
0.044337764382362366,
-0.0030109898652881384,
0.017095088958740234,
0.03186921030282974,
-0.005736907944083214,
-0.009098472073674202,
0.028455162420868874,
0.022443968802690506,
-0.013364389538764954,
-0.01137388963252306,
0.02112250030040741,
0.008219529874622822,
0.021549910306930542,
0.024093061685562134,
-0.0017180417198687792,
0.0035272552631795406,
0.01220033224672079,
-0.013427798636257648,
-0.016193948686122894,
0.03892110288143158,
-0.01254027709364891,
-0.03225182369351387,
0.001300574280321598,
-0.010021716356277466,
-0.00013918522745370865,
-0.011850344017148018,
-0.015845825895667076,
-0.003256754018366337,
-0.03207913786172867,
0.01228672917932272,
0.018331514671444893,
0.02182452380657196,
0.00760481134057045,
0.0022443649359047413,
-0.029931901022791862,
0.020328909158706665,
0.00030619348399341106,
0.01800631545484066,
0.005028857849538326,
-0.027170594781637192,
0.03245344012975693,
0.017546415328979492,
-0.0030216947197914124,
0.012567942962050438,
-0.012386509217321873,
-0.04372250288724899,
-0.04708950221538544,
0.006045325193554163,
-0.0005517172394320369,
0.011266594752669334,
-0.042532697319984436,
-0.008223053999245167,
0.01948816329240799,
-0.009959157556295395,
-0.01821466162800789,
0.018635928630828857,
-0.010449535213410854,
-0.025916745886206627,
-0.026510018855333328,
-0.0019819876179099083,
0.0009999447502195835,
-0.004696166608482599,
-0.008084071800112724,
0.04938787966966629,
0.007225013338029385,
-0.020557813346385956,
0.0015314326155930758,
-0.0036250711418688297,
0.07082145661115646,
0.015647659078240395,
-0.01572398655116558,
-0.02172023057937622,
0.05828038603067398,
0.0008706941734999418,
0.03490401804447174,
0.003913997206836939,
0.0015821810811758041,
-0.026776917278766632,
0.017203902825713158,
-0.013019764795899391,
-0.028386419638991356,
0.01061313971877098,
-0.01585249975323677,
0.000028086360543966293,
-0.02581607922911644,
-0.03798241168260574,
0.06717821955680847,
0.019318584352731705,
0.009807486087083817,
-0.014644719660282135,
0.016804853454232216,
-0.03547254949808121,
-0.0023110643960535526,
-0.0335882231593132,
0.00886504352092743,
-0.019948691129684448,
-0.002166139427572489,
0.00534114520996809,
-0.024576228111982346,
-0.0575522817671299,
-0.007448791991919279,
-0.018138501793146133,
0.03882559388875961,
-0.023544102907180786,
-0.002258642576634884,
-0.01691676490008831,
-0.014738529920578003,
0.0035281945019960403,
0.014141416177153587,
-0.017131224274635315,
0.000004886649549007416,
0.009411811828613281,
-0.00028619589284062386,
0.009786713868379593,
-0.01404498890042305,
-0.009916863404214382,
-0.012733934447169304,
0.004905389621853828,
-0.01715966686606407,
0.0014740764163434505,
0.007237832527607679,
0.01610691472887993,
0.008263643831014633,
-0.01798122748732567,
0.04497747868299484,
0.000464782293420285,
0.002945947926491499,
-0.005416011903434992,
-0.014913896098732948,
0.012986746616661549,
0.044513072818517685,
-0.022585853934288025,
0.011648532003164291,
-0.03388764709234238,
-0.009547369554638863,
-0.0008081472478806973,
-0.008905677124857903,
-0.009450558573007584,
0.015039216727018356,
0.015381202101707458,
-0.027307122945785522,
0.008112244307994843,
-0.04891222342848778,
0.004642412066459656,
-0.028537089005112648,
-0.007349018938839436,
0.031486958265304565,
-0.0304156132042408,
0.005980519577860832,
0.00910646840929985,
0.020191369578242302,
-0.0066444044932723045,
0.002819903427734971,
-0.033908311277627945,
-0.030606046319007874,
-0.07448474317789078,
-0.03556052967905998,
0.0013407242950052023,
-0.010965971276164055,
0.015263200737535954,
0.029700852930545807,
-0.02645784243941307,
0.03496011346578598,
-0.047916557639837265,
-0.014211645349860191,
-0.029039444401860237,
-0.007422091439366341,
0.0329945906996727,
-0.008752034045755863,
0.011724716983735561,
-0.027820466086268425,
0.010502791963517666,
-0.003538970835506916,
-0.01571514829993248,
-0.01869133487343788,
-0.03710852190852165,
-0.021093493327498436,
-0.029097897931933403,
0.009451672434806824,
-0.004731564782559872,
-0.07965714484453201,
0.01070242840796709,
0.02455141395330429,
0.00630380492657423,
-0.004207144491374493,
0.009322697296738625,
0.031483326107263565,
-0.010919646359980106,
0.020420050248503685,
-0.024898558855056763,
-0.004007748328149319,
0.022814834490418434,
-0.012626036070287228,
0.01446525752544403,
0.026066459715366364,
-0.01604778692126274,
0.01795274391770363,
0.05023699253797531,
0.030579086393117905,
-0.007674124091863632,
-0.0024210549890995026,
-0.023055873811244965,
-0.012281743809580803,
-0.026922401040792465,
-0.010402661748230457,
-0.02083968184888363,
-0.0030333204194903374,
0.01992906630039215,
-0.01980508118867874,
-0.005925889126956463,
-0.017051754519343376,
0.002257741056382656,
-0.0003508228110149503,
0.005891228560358286,
-0.009776372462511063,
0.0025371741503477097,
-0.00786223728209734,
-0.013539833948016167,
-0.020774470642209053,
0.007520375773310661,
-0.00500519061461091,
-0.008836823515594006,
0.02357570081949234,
0.012889562174677849,
-0.002365713007748127,
-0.02389438822865486,
0.003398369299247861,
-0.01368299126625061,
0.019173089414834976,
-0.00667300121858716,
0.011588960886001587,
0.0035664234310388565,
0.0072861225344240665,
-0.013734916225075722,
0.011647185310721397,
-0.002469405997544527,
-0.009514661505818367,
0.01624663919210434,
0.019005581736564636,
0.012072259560227394,
-0.01447245292365551,
0.010077067650854588,
0.008392870426177979,
0.07059626281261444,
0.00807514414191246,
0.032911572605371475,
-0.014940828084945679,
0.0018102701287716627,
0.0034107223618775606,
-0.00836203247308731,
-0.019862104207277298,
0.000977438990958035,
-0.015303628519177437,
0.023144759237766266,
-0.0050587961450219154,
-0.003037284594029188,
0.01523466594517231,
0.00352609739638865,
-0.014696566388010979,
0.010533677414059639,
-0.015202738344669342,
-0.06897052377462387,
0.04389730095863342,
-0.01278630644083023,
-0.00693944888189435,
-0.007023981306701899,
-0.006004500202834606,
-0.0029206760227680206,
0.0023466176353394985,
-0.003862805664539337,
0.015071443282067776,
-0.0353223942220211,
0.04150843620300293,
0.0035591511987149715,
-0.014418699778616428,
-0.00029212189838290215,
-0.00524910818785429,
0.000610030023381114,
0.007470056414604187,
-0.006306490395218134,
0.009246495552361012,
0.018057947978377342,
-0.016192233189940453,
0.006609494797885418,
-0.01015782542526722,
-0.00540004950016737,
-0.02684200555086136,
0.016158897429704666,
-0.03742373734712601,
-0.008616339415311813,
0.0018330225721001625,
0.02628318965435028,
0.01850920170545578,
0.0025877607986330986,
-0.007546522654592991,
-0.01007441058754921,
0.0007810168899595737,
0.011425280012190342,
0.004412660375237465,
-0.012753919698297977,
0.013471610844135284,
0.0038237953558564186,
0.017943384125828743,
-0.02052038535475731,
-0.021504070609807968,
0.01083129271864891,
-0.025478392839431763,
0.04885947331786156,
-0.044419750571250916,
-0.001463770866394043,
-0.015320058912038803,
-0.0437266044318676,
0.029562976211309433,
-0.0534975565969944,
-0.013400491327047348,
0.0068334005773067474,
0.0019161393865942955,
0.04230668023228645,
0.02551151067018509,
-0.006342549808323383,
-0.01102006621658802,
0.024539344012737274,
0.007674750406295061,
-0.015931006520986557,
0.02836606651544571,
-0.03062605857849121,
0.0034742048010230064,
0.02164483815431595,
-0.02360481582581997,
-0.005849810317158699,
-0.023655813187360764,
0.0060064345598220825,
0.0165921151638031,
-0.040591925382614136,
0.014397973194718361,
0.002075331984087825,
-0.003185185370966792,
0.006263045594096184,
0.037224963307380676,
0.03147275000810623,
0.018546059727668762,
-0.0339626744389534,
0.01323830895125866,
0.009394485503435135,
0.006239931099116802,
-0.00860143918544054,
0.010609602555632591,
-0.03798125684261322,
-0.007364506833255291,
0.015813326463103294,
0.013071427121758461,
-0.012551117688417435,
-0.01837373524904251,
0.021734777837991714,
0.023519445210695267,
0.029182331636548042,
-0.018945038318634033,
-0.006000812631100416,
0.01974634826183319,
-0.004421011544764042,
-0.01108437031507492,
0.031311459839344025,
-0.004302594345062971,
0.0009432502556592226,
0.00014267629012465477,
-0.020246140658855438,
-0.006270984187722206,
-0.013800909742712975,
-0.022746041417121887,
-0.007215168792754412,
0.02675294503569603,
0.029379714280366898,
-0.009368345141410828,
0.026668310165405273,
0.006611098535358906,
0.011730286292731762,
0.01395212858915329,
0.012244760990142822,
0.04163387045264244,
0.006627780385315418,
-0.012791871093213558,
0.014643292874097824,
0.004694857634603977,
0.0005457010120153427,
-0.001135986763983965,
0.009031024761497974,
0.03333098813891411,
0.010306710377335548,
-0.02657637931406498,
0.036170847713947296,
0.04136816784739494,
0.0005705022485926747,
-0.003317697439342737,
-0.0072943982668221,
0.029219109565019608,
0.022827353328466415,
-0.005469820462167263,
0.001108792144805193,
0.013326598331332207,
0.0029632518999278545,
-0.026930086314678192,
-0.018723465502262115,
-0.008644909597933292,
0.01803317852318287,
-0.015054833143949509,
0.04015178978443146,
0.0076649608090519905,
-0.008534095250070095,
0.018093716353178024,
0.018193013966083527,
0.017886631190776825,
-0.005123968236148357,
0.02425248548388481,
0.015429356135427952,
-0.03235061094164848,
0.023079242557287216,
0.012397853657603264,
-0.004905496723949909,
-0.011021601967513561,
-0.016118403524160385,
-0.002663474064320326,
0.027563199400901794,
0.0033616386353969574,
0.022567719221115112,
-0.03178006783127785,
0.018473215401172638,
-0.010520229116082191,
0.005460518412292004,
-0.01941569149494171,
-0.0031774230301380157,
0.011919856071472168,
0.01060003787279129,
0.024918511509895325,
-0.021422654390335083,
0.0046472977846860886,
-0.012842150405049324,
0.03332138806581497,
0.0017526724841445684,
-0.025547992438077927,
0.002507191151380539,
-0.045572660863399506,
-0.007387382909655571,
0.006073676515370607,
-0.020684193819761276,
0.0015569350216537714
] | [
-0.0669417679309845,
0.09828437864780426,
0.025237297639250755,
-0.5576643943786621,
-0.18733055889606476,
-0.4344281852245331,
0.33548492193222046,
-0.1622539907693863,
-0.04834518954157829,
-0.4056128263473511,
-0.2077738344669342,
0.3430608808994293,
-0.7970321178436279,
0.08297330141067505,
-0.13152511417865753,
0.4228913187980652,
0.31651976704597473,
0.3966260254383087,
-0.2900087237358093,
-0.35572001338005066,
-0.15597237646579742,
-0.06083424761891365,
0.3765014410018921,
0.12529990077018738,
0.6597919464111328,
-0.29201963543891907,
0.5403660535812378,
-0.2712746858596802,
0.5069347023963928,
-0.2924842834472656,
0.1453818380832672,
0.4199546277523041,
-0.08384741097688675,
-0.455785870552063,
-0.5654327869415283,
0.2628605365753174,
-0.38717570900917053,
-0.3785436749458313,
-0.12318119406700134,
0.4105675518512726,
-0.8043203353881836,
-0.4190923273563385,
-0.41073495149612427,
0.5315378904342651,
-0.2005658745765686,
-0.3332667052745819,
-1.4867547750473022,
1.0155428647994995,
-0.22996780276298523,
0.2797102630138397,
-0.02690921165049076,
0.059919651597738266,
0.21588268876075745,
0.04546467587351799,
0.6048187613487244,
-0.11914990842342377,
-0.54407799243927,
-0.12443354725837708,
0.5666370987892151,
-0.8051408529281616,
-0.04860522225499153,
0.054055482149124146,
-0.3588511049747467,
-0.031781382858753204,
-0.11130586266517639,
0.7800712585449219,
0.03981412947177887,
-0.21799713373184204,
-0.5571931004524231,
-0.1549586057662964,
-0.006925623863935471,
-0.26260098814964294,
-0.552628219127655,
-0.10420231521129608,
0.3077256679534912,
-0.3335825502872467,
-0.22734244167804718,
-0.2199322134256363,
-0.4201248586177826,
-0.11071757227182388,
-0.05930253490805626,
0.10585711151361465,
0.34643423557281494,
-0.29257136583328247,
0.44907689094543457,
-0.35753172636032104,
-0.22613365948200226,
1.0980366468429565,
-0.29445067048072815,
-0.16892872750759125,
0.0748823881149292,
0.06860395520925522,
0.3423982858657837,
0.21084003150463104,
0.31689542531967163,
0.514173686504364,
0.1093512624502182,
-0.04755673557519913,
0.031002063304185867,
0.45605406165122986,
0.05328337848186493,
0.05021784454584122,
0.15893712639808655,
-0.5960805416107178,
-0.11370808631181717,
-0.14232248067855835,
0.014614615589380264,
-0.6864761710166931,
-0.4677090048789978,
0.20735149085521698,
-0.7831505537033081,
0.2151132971048355,
-0.21929650008678436,
-0.3586530387401581,
0.020572615787386894,
-0.034644223749637604,
0.2748224139213562,
-0.17688162624835968,
0.046024616807699203,
0.14252451062202454,
0.11886913329362869,
1.565351963043213,
-0.2794530391693115,
0.5555163621902466,
-0.19116805493831635,
-0.0578090064227581,
0.11750571429729462,
0.15219177305698395,
-0.17671312391757965,
0.27500060200691223,
0.03521287441253662,
0.691818356513977,
-0.4374222755432129,
-0.09838730096817017,
0.03269170969724655,
0.38392388820648193,
0.2523825466632843,
0.007881365716457367,
0.45376884937286377,
0.09626633673906326,
-0.41566014289855957,
-0.3634071350097656,
-0.0010663410648703575,
-0.14204992353916168,
-0.0933380126953125,
-0.484999418258667,
-0.19518765807151794,
0.07032414525747299,
0.2102380096912384,
-0.008357804268598557,
-0.2543111741542816,
-0.44418033957481384,
-0.8826899528503418,
0.1961892694234848,
0.14231733977794647,
0.1946469247341156,
0.3239961564540863,
-0.265689492225647,
0.018761374056339264,
0.3392484486103058,
0.277352511882782,
-0.2644771337509155,
-0.5092213749885559,
0.12894494831562042,
0.4885733723640442,
-0.08765866607427597,
0.11480805277824402,
0.4844132661819458,
0.21187573671340942,
-0.46166399121284485,
-0.3819343149662018,
-0.2940707802772522,
0.26733681559562683,
-0.7514652013778687,
0.04018406569957733,
-0.19404244422912598,
0.020677348598837852,
-0.18531504273414612,
0.07834429293870926,
0.19767224788665771,
-0.9695339202880859,
-0.3813329339027405,
-0.24720756709575653,
-0.446965754032135,
0.4474198818206787,
0.23223057389259338,
0.36493992805480957,
-0.11366859078407288,
-0.17235827445983887,
-0.06544244289398193,
0.1168002337217331,
-0.17259113490581512,
0.3773360848426819,
-0.6633120775222778,
1.695094108581543,
-0.12021079659461975,
-0.33984389901161194,
1.4651647806167603,
0.42967116832733154,
-0.3993200957775116,
-0.11195108294487,
-0.05397763103246689,
0.7439833283424377,
-0.03159893676638603,
-0.2386457771062851,
-0.04824531078338623,
-0.29771772027015686,
0.21457839012145996,
0.19883130490779877,
0.35247933864593506,
0.42331910133361816,
-0.6349339485168457,
0.23863451182842255,
-0.29946547746658325,
0.019139790907502174,
-0.3813207745552063,
-0.33492669463157654,
0.13476604223251343,
-0.6288728713989258,
0.4845309555530548,
0.07426400482654572,
-0.26014187932014465,
0.4584336280822754,
1.3121967315673828,
0.20791921019554138,
0.6857077479362488,
0.5313765406608582,
0.40190666913986206,
0.736798882484436,
-0.18415066599845886,
0.49824514985084534,
-0.7680043578147888,
0.3667200207710266,
-0.2919709384441376,
-0.08441326022148132,
0.12167204916477203,
0.12975835800170898,
-0.06331625580787659,
-0.3721521496772766,
-0.15938878059387207,
-0.20176509022712708,
0.8376023173332214,
-1.006819248199463,
0.2542760968208313,
0.08559687435626984,
-0.30171453952789307,
-0.16725917160511017,
0.18870335817337036,
-0.8084499835968018,
0.08249888569116592,
-0.004449403844773769,
-0.054238177835941315,
0.2324691265821457,
-0.7043682336807251,
0.26529020071029663,
-0.11395668238401413,
-0.19447536766529083,
-0.19630379974842072,
0.4138321876525879,
-0.5603839755058289,
0.16643355786800385,
-0.1963203251361847,
0.18681691586971283,
0.44673603773117065,
-0.3616023063659668,
-0.10600744932889938,
-0.3318079710006714,
-0.2507447302341461,
0.9666726589202881,
0.5403080582618713,
1.020218014717102,
0.0070161414332687855,
-0.45287463068962097,
-0.043419819325208664,
-0.1658404916524887,
-0.3291202187538147,
0.1724865585565567,
0.806329071521759,
-0.5324761271476746,
0.22970224916934967,
-0.2207304686307907,
-0.09542379528284073,
0.5545292496681213,
0.047829221934080124,
-0.677241325378418,
0.06913864612579346,
-0.2492835372686386,
-0.5097312331199646,
-0.5220535397529602,
-0.3890339732170105,
-0.38637757301330566,
0.2290574163198471,
-0.1762521117925644,
0.28628110885620117,
0.2826177477836609,
0.026935283094644547,
0.0565762035548687,
0.5863333344459534,
0.4592677652835846,
-0.2290632426738739,
-0.0216892808675766,
0.45712652802467346,
-0.6546098589897156,
0.2960488498210907,
-0.4377259612083435,
0.1375032216310501,
-0.268642395734787,
0.1013825312256813,
-5.657973289489746,
0.15938425064086914,
0.30768316984176636,
0.0037746254820376635,
-0.15647906064987183,
-0.2484440952539444,
0.9838767051696777,
-0.12883691489696503,
0.42232829332351685,
0.5793632864952087,
0.2211894690990448,
0.16098450124263763,
-0.14306671917438507,
0.18878059089183807,
-0.40612244606018066,
-0.14982102811336517,
-0.3214080333709717,
-0.37598660588264465,
0.7620201110839844,
0.2665552496910095,
0.37747350335121155,
0.1389775574207306,
-0.09276053309440613,
0.610004723072052,
-0.1267675757408142,
-0.4470067024230957,
-0.5164722204208374,
-0.0862332358956337,
0.18846936523914337,
-0.5929613709449768,
0.2772201895713806,
-0.4394194483757019,
0.023557672277092934,
-0.01788662001490593,
0.2773105800151825,
0.24551622569561005,
0.342526912689209,
-0.11827228218317032,
-0.021927542984485626,
-0.30618730187416077,
0.3293040990829468,
0.27032896876335144,
-0.22805947065353394,
0.3910817801952362,
0.6091150045394897,
-0.17029814422130585,
-0.08673021197319031,
0.25284963846206665,
-0.6676413416862488,
0.8345311880111694,
-0.3007117509841919,
-0.2481745481491089,
0.5492728352546692,
0.43862277269363403,
0.5775550007820129,
0.06416983902454376,
-0.44572943449020386,
-0.026282578706741333,
-0.48937132954597473,
-0.07607383280992508,
-0.5991286635398865,
0.17252658307552338,
-0.6650633215904236,
-0.3146253228187561,
0.17374840378761292,
0.1647685468196869,
-0.5208471417427063,
-0.4203557074069977,
0.7665403485298157,
-0.3104793131351471,
-0.2950364947319031,
0.2724485397338867,
0.26430827379226685,
-0.8054882884025574,
0.7187836170196533,
-0.027319500222802162,
0.2673017680644989,
-0.01652023382484913,
0.06435836106538773,
0.024449873715639114,
-0.751072883605957,
0.21178701519966125,
-0.0065396330319345,
0.19194751977920532,
0.48171162605285645,
-0.143862783908844,
-0.118187814950943,
-0.04410639777779579,
-0.15403585135936737,
0.38530200719833374,
0.8559014797210693,
-0.15139628946781158,
-0.09446791559457779,
0.5427817106246948,
-0.02088669314980507,
0.6010841727256775,
0.29716336727142334,
0.5527850985527039,
0.765362560749054,
0.35443609952926636,
0.8857570886611938,
-0.011804718524217606,
-0.18843267858028412,
-0.9107712507247925,
-0.10539895296096802,
0.37096238136291504,
-0.44095149636268616,
0.21293243765830994,
0.7124677896499634,
-0.9572197198867798,
0.12001749128103256,
0.029876813292503357,
-0.6954348683357239,
-0.11689990758895874,
0.43186503648757935,
-0.19187036156654358,
0.013443333096802235,
0.26720336079597473,
0.46836596727371216,
-0.03640417754650116,
0.013598497956991196,
0.27549004554748535,
-0.8993134498596191,
0.38330772519111633,
0.2690514624118805,
-0.26216253638267517,
-0.23459292948246002,
0.8887607455253601,
-0.6179866790771484,
-0.6548792123794556,
0.5803396701812744,
0.5346948504447937,
-0.45668384432792664,
0.14139306545257568,
0.32719728350639343,
-0.5684302449226379,
-0.33842185139656067,
0.19943097233772278,
0.09559936821460724,
-0.3274194598197937,
0.3600001037120819,
-0.3841422498226166,
0.10999500006437302,
0.0843980684876442,
0.21104854345321655,
0.12437482923269272,
0.013504731468856335,
0.18155448138713837,
-0.5725455284118652,
-0.4586208164691925,
0.22083725035190582,
-0.04340658336877823,
0.1110350713133812,
-0.07466395199298859,
-0.20601211488246918,
0.6357631683349609,
0.6025761961936951,
0.2440367043018341,
0.3292771577835083,
-0.4252978265285492,
0.11325082927942276,
0.31515762209892273,
-0.601094126701355,
0.19060252606868744,
-0.35670238733291626,
-0.14989341795444489,
-0.36034369468688965,
-0.4785625636577606,
0.031058138236403465,
0.32034432888031006,
-0.7274124026298523,
-0.033500075340270996,
-0.2884890139102936,
-0.38810861110687256,
0.14602863788604736,
-0.3133637011051178,
-0.26895642280578613,
0.149697408080101,
-0.05734989419579506,
-0.15077213943004608,
0.368337482213974,
-0.5828777551651001,
-0.525239109992981,
0.3133346140384674,
0.4612487852573395,
-0.23073579370975494,
0.21338050067424774,
-0.05249471589922905,
0.02831438183784485,
-0.5888664722442627,
0.26230406761169434,
0.0796818733215332,
0.11949920654296875,
-0.46003854274749756,
0.23949654400348663,
0.20579248666763306,
0.2158162146806717,
0.39915379881858826,
-0.0022467675153166056,
-0.6833946704864502,
0.20439815521240234,
0.19275955855846405,
-0.6638166904449463,
0.21790054440498352,
0.08902466297149658,
0.12655408680438995,
-0.2790513336658478,
0.2440899908542633,
-0.23098275065422058,
-0.09783735126256943,
-0.25088608264923096,
-0.5553160309791565,
0.31631267070770264,
0.13215719163417816,
0.11597755551338196,
0.1314374953508377,
-0.006117234472185373,
-0.17372256517410278,
-0.27000123262405396,
0.3184814155101776,
0.26697400212287903,
-0.22773224115371704,
0.2126031219959259,
0.16344663500785828,
-0.642962634563446,
-0.28717276453971863,
0.29684871435165405,
-0.8166163563728333,
0.41115543246269226,
-0.06415560841560364,
0.32811078429222107,
0.08038907498121262,
0.09793145954608917,
0.23688536882400513,
-0.223049595952034,
-0.5835909247398376,
-0.07767146825790405,
0.2789233326911926,
-0.1242666095495224,
0.8444761037826538,
0.21575668454170227,
0.4700937271118164,
-0.2770926058292389,
0.10173541307449341,
-0.1815681755542755,
0.4727979004383087,
0.42784690856933594,
-0.45019689202308655,
-0.3672344982624054,
0.23967887461185455,
0.4155455231666565,
0.13510343432426453,
-0.11350511014461517,
0.5267843008041382,
0.8651567101478577,
-0.3994095027446747,
-0.1562548279762268,
-0.003192243631929159,
-0.2844645380973816,
0.04719050973653793,
-0.5533984899520874,
-0.029292967170476913,
-0.08494217693805695,
0.09285840392112732,
0.238908588886261,
-0.21509049832820892,
-0.37451961636543274,
-1.1748385429382324,
0.5992303490638733,
-0.141546830534935,
-0.11472674459218979,
-0.48878973722457886,
0.9280495643615723,
0.2290971726179123,
-0.2799305319786072,
0.42662644386291504,
-0.3466030955314636,
0.2543441653251648,
-0.20783157646656036,
0.012629522010684013,
0.005943051539361477,
-0.7920024991035461,
0.31501731276512146,
-0.6789054870605469,
0.5627402067184448,
-0.8109222650527954,
0.07127775996923447,
-0.7574610710144043,
0.17566587030887604,
-0.2408679723739624,
-0.57961505651474,
0.06659314036369324,
-0.7741000056266785,
-0.47405195236206055,
-0.1842203587293625,
0.1787986159324646,
0.11963384598493576,
0.15593910217285156,
-0.39055490493774414,
-0.17993855476379395,
-0.6497311592102051,
-0.0690276101231575,
0.6954413652420044,
-0.4724937379360199,
-0.3491717278957367,
0.1477353572845459,
0.0650106817483902,
0.1508111208677292,
-0.5279499292373657,
-0.1856374442577362,
-0.3392363488674164,
-0.14943520724773407,
0.29879480600357056,
0.06304538995027542,
-0.3782060742378235,
0.43117520213127136,
0.04268288239836693,
-0.32275429368019104,
0.32369735836982727,
0.16888174414634705,
0.17384406924247742,
0.3483591079711914,
0.13103656470775604,
0.020830674096941948,
-0.12286729365587234,
0.19512327015399933,
0.8632703423500061,
0.39253097772598267,
-0.1425630897283554,
0.4480091631412506,
0.3522854745388031,
0.06017064303159714,
-0.11311302334070206,
0.8404473066329956,
0.23290571570396423,
-0.1314718872308731,
0.5712565779685974,
-0.6174101233482361,
-0.7332906126976013,
0.06362856924533844,
0.5019220113754272,
0.7425716519355774,
-0.32723551988601685,
-0.2433454692363739,
0.33887043595314026,
0.25227922201156616,
0.4584828317165375,
0.4425296187400818,
-0.5167899131774902,
0.5111744403839111,
0.46844005584716797,
-0.5094965696334839,
-0.43002647161483765,
-0.3992236256599426,
-0.5945597290992737,
0.2898271679878235,
0.5837929248809814,
-0.625586748123169,
-0.36750707030296326,
0.1587955504655838,
-0.1600237935781479,
0.029111327603459358,
0.06465958803892136,
0.6652261018753052,
0.10696530342102051,
-0.0007531745941378176,
0.33622729778289795,
0.40175288915634155,
0.3789198398590088,
-0.22966723144054413,
-0.005786275491118431,
-0.12597030401229858,
-0.040395740419626236,
0.0998450368642807,
0.33891332149505615,
-0.4850689172744751,
0.19152617454528809,
-0.0013043431099504232,
-0.3308984041213989,
0.7204157114028931,
-0.47072041034698486,
0.3776963949203491,
-0.42615795135498047,
-0.7028562426567078,
-0.5000057220458984,
-0.3700488209724426,
-0.5964720249176025,
0.008148758672177792,
-0.31038689613342285,
0.061862487345933914,
0.2318500280380249,
-0.33725422620773315,
0.2278083711862564,
0.2362019121646881,
-0.053589385002851486,
-0.05761529877781868,
0.3390364348888397,
0.1664445400238037,
0.08704044669866562,
0.5045346617698669,
0.3431413471698761,
0.4159868061542511,
0.022021405398845673,
0.4594604969024658,
-0.7311119437217712,
0.7569718360900879,
-0.5782740116119385,
-0.5299229621887207,
-0.3965727984905243,
-0.34083065390586853,
1.2411683797836304,
1.0133850574493408,
-0.17659631371498108,
0.048086415976285934,
0.4376169443130493,
0.19554582238197327,
0.5097745060920715,
-0.5580750107765198,
-0.14862656593322754,
-0.4952253997325897,
0.1431339532136917,
-0.6071121692657471,
0.6847407817840576,
0.19543586671352386,
-0.4507402181625366,
0.12304989993572235,
0.7695716619491577,
0.09301915764808655,
-0.04902874305844307,
-0.009367140009999275,
-0.4054369628429413,
-0.342040479183197,
-0.5619147419929504,
0.22869612276554108,
-0.4236861765384674,
-0.20373523235321045,
-0.42355602979660034,
-0.17694000899791718,
0.4603918790817261,
0.06348314136266708,
0.26402708888053894,
0.12071642279624939,
-0.05579689145088196,
0.17095410823822021,
0.11606532335281372,
0.2498513162136078,
-0.07997188717126846,
-1.0398664474487305,
-0.26652029156684875,
0.1860809177160263,
0.11297832429409027,
-0.8873618245124817,
-0.10875106602907181,
0.6690050959587097,
-0.25664642453193665,
-0.241861492395401,
0.1601475477218628,
-0.3371015191078186,
-0.14869247376918793,
-0.14756804704666138
] |
Background Since its initial detection in April 2009, the A/H1N1pdm influenza virus has spread rapidly in humans, with over 5,700 human deaths. However, little is known about the evolutionary dynamics of H1N1pdm and its geographic and temporal diversification. Methods Phylogenetic analysis was conducted upon the concatenated coding regions of whole-genome sequences from 290 H1N1pdm isolates sampled globally between April 1 – July 9, 2009, including relatively large samples from the US states of Wisconsin and New York. Results At least 7 phylogenetically distinct viral clades have disseminated globally and co-circulated in localities that experienced multiple introductions of H1N1pdm. The epidemics in New York and Wisconsin were dominated by two different clades, both phylogenetically distinct from the viruses first identified in California and Mexico, suggesting an important role for founder effects in determining local viral population structures. Conclusions Determining the global diversity of H1N1pdm is central to understanding the evolution and spatial spread of the current pandemic, and to predict its future impact on human populations. Our results indicate that H1N1pdm has already diversified into distinct viral lineages with defined spatial patterns. | [
-0.00913059338927269,
0.013884808868169785,
-0.012002799659967422,
0.02913094311952591,
-0.00020093261264264584,
0.0007593173068016768,
0.008024768903851509,
0.01614736206829548,
-0.01803291030228138,
-0.015322988852858543,
0.010914578102529049,
0.01916302740573883,
0.0017954582581296563,
-0.00504861306399107,
0.012506385333836079,
-0.012490867637097836,
-0.017509521916508675,
-0.0016356948763132095,
0.01635480672121048,
-0.01024491898715496,
0.005728475749492645,
0.013115495443344116,
0.011511597782373428,
0.030445657670497894,
0.012496335431933403,
-0.0012226086109876633,
-0.007449006661772728,
-0.015485860407352448,
0.0008406257256865501,
-0.00582969980314374,
0.024847140535712242,
0.01893581449985504,
-0.017109282314777374,
-0.006406223401427269,
-0.004852365702390671,
0.021393021568655968,
0.0009303621482104063,
0.014469575136899948,
-0.022707771509885788,
-0.004888611845672131,
0.023015983402729034,
-0.022516559809446335,
0.0027112504467368126,
-0.0011791195720434189,
-0.012310503050684929,
0.019104626029729843,
-0.01687893271446228,
0.008402194827795029,
0.006909678690135479,
0.013576535508036613,
-0.009995032101869583,
-0.0022410964593291283,
-0.021294139325618744,
0.02779945731163025,
-0.0067652203142642975,
-0.01062082964926958,
0.022748922929167747,
0.015112658962607384,
-0.00633035134524107,
0.02503160387277603,
-0.008096138946712017,
0.0032477956265211105,
0.011163707822561264,
-0.018834207206964493,
0.008618771098554134,
-0.06635721027851105,
0.019942158833146095,
-0.005888327956199646,
0.005330805201083422,
-0.01467457041144371,
-0.011906040832400322,
0.013661349192261696,
-0.011363006196916103,
0.00193755142390728,
-0.011519751511514187,
0.008362867869436741,
0.01330781914293766,
0.029784051701426506,
0.01095028780400753,
0.0014937268570065498,
-0.004205585923045874,
-0.024762773886322975,
0.019568918272852898,
0.022001763805747032,
-0.010769812390208244,
0.024760525673627853,
-0.0237258467823267,
0.004570034332573414,
0.014851748012006283,
-0.002332462463527918,
0.017239229753613472,
-0.014445374719798565,
-0.0249650776386261,
-0.019305627793073654,
-0.009379705414175987,
0.006231571082025766,
-0.0027019083499908447,
0.025258369743824005,
-0.015921015292406082,
-0.01264305878430605,
0.007694011554121971,
0.02921781875193119,
0.020713381469249725,
0.0002949154004454613,
-0.027990378439426422,
0.008464440703392029,
-0.02448250912129879,
0.012576993554830551,
0.013877477496862411,
-0.0046343752183020115,
-0.003362237010151148,
-0.0068173035979270935,
-0.009859921410679817,
0.030217720195651054,
-0.00522962398827076,
-0.004073807504028082,
0.00558039266616106,
0.025541769340634346,
-0.004516813438385725,
0.003535693511366844,
0.007202161941677332,
0.0011344216763973236,
-0.004214344546198845,
0.021802283823490143,
-0.0032467027194797993,
0.015799229964613914,
0.0026417947374284267,
-0.0025487863458693027,
0.025538668036460876,
-0.0031887281220406294,
-0.0043664113618433475,
-0.0017415154725313187,
-0.03758774325251579,
-0.022944461554288864,
0.0092769805341959,
-0.003875088645145297,
-0.023366732522845268,
0.008174434304237366,
-0.02513698861002922,
-0.007917515002191067,
0.005430892575532198,
0.013025401160120964,
0.005111724138259888,
0.02452694997191429,
0.005164069589227438,
0.018505657091736794,
0.0100368931889534,
0.00044761947356164455,
0.021080555394291878,
0.007970139384269714,
0.009378636255860329,
-0.0024489210918545723,
-0.025058193132281303,
-0.019710469990968704,
-0.003618510439991951,
0.016251355409622192,
0.0009056671988219023,
-0.04419028013944626,
0.0004500076174736023,
-0.0007888097316026688,
-0.003368469886481762,
0.002408437430858612,
0.00059914356097579,
0.009279076009988785,
0.03168223798274994,
-0.019806232303380966,
-0.0040438128635287285,
-0.003002028912305832,
-0.007686901837587357,
0.0032931354362517595,
0.0061525036580860615,
0.015788903459906578,
0.022067807614803314,
0.020181667059659958,
0.026360802352428436,
-0.010723554529249668,
0.0054306527599692345,
0.00687843281775713,
0.010150164365768433,
0.06579829752445221,
0.0021583647467195988,
-0.021215688437223434,
-0.00901741161942482,
0.03063470497727394,
0.0037757784593850374,
-0.030121836811304092,
0.023264411836862564,
-0.015133905224502087,
-0.024285607039928436,
-0.005437327548861504,
-0.02093070186674595,
-0.008618355728685856,
-0.004424010869115591,
0.00821166392415762,
0.0024261344224214554,
0.00218734098598361,
0.01981068029999733,
-0.003717548679560423,
-0.01637115515768528,
0.03636261448264122,
0.005475475452840328,
0.012122223153710365,
0.026136865839362144,
0.00947333313524723,
-0.01571148820221424,
0.012068355455994606,
0.008284976705908775,
0.012749111279845238,
0.010825448669493198,
0.0009581544436514378,
0.0037836777046322823,
-0.02526811510324478,
-0.006332859862595797,
-0.007278552744537592,
-0.03814193233847618,
0.0045572263188660145,
-0.0006145620718598366,
-0.004284887574613094,
-0.016324294731020927,
-0.017405707389116287,
0.005424791015684605,
0.0055820150300860405,
-0.016613299027085304,
0.02418763004243374,
0.012568684294819832,
-0.01626145839691162,
-0.008376948535442352,
0.013775994069874287,
0.012837545946240425,
0.0009854220552369952,
0.00205397792160511,
0.009322321973741055,
-0.014437420293688774,
0.010554947890341282,
0.025155633687973022,
0.014498041942715645,
0.015784841030836105,
-0.03867174685001373,
-0.0024393091443926096,
-0.01610594615340233,
-0.025461116805672646,
-0.03057841770350933,
0.006477731745690107,
-0.028221990913152695,
0.022495195269584656,
0.009619015268981457,
0.019470248371362686,
0.0011532604694366455,
-0.014536377973854542,
-0.004133689682930708,
0.012077337130904198,
-0.0025908376555889845,
0.0432308092713356,
-0.015606553293764591,
-0.011205371469259262,
-0.009432254359126091,
-0.002476709894835949,
-0.014325527474284172,
0.02645293064415455,
0.0295368954539299,
0.015158278867602348,
0.00471075065433979,
-0.021536998450756073,
-0.024810079485177994,
-0.014605884440243244,
0.014558814465999603,
0.0005461964756250381,
0.011742094531655312,
0.01576198823750019,
-0.008546366356313229,
0.007670244202017784,
-0.018647994846105576,
-0.001124982489272952,
-0.08081439137458801,
-0.0040593016892671585,
0.011067047715187073,
-0.013129901140928268,
0.013051485642790794,
0.006696880795061588,
0.008060178719460964,
0.006105827167630196,
0.0023091481998562813,
-0.006225228309631348,
0.016122497618198395,
0.04027358442544937,
-0.0004190441977698356,
0.028935182839632034,
-0.007849358022212982,
0.010442529805004597,
0.01005004532635212,
0.017992742359638214,
-0.003678280860185623,
-0.008813099004328251,
-0.018343010917305946,
-0.00681128678843379,
0.01702289655804634,
-0.013046500273048878,
0.0046259136870503426,
-0.02357078716158867,
0.022366855293512344,
-0.004797852132469416,
0.0004079020582139492,
0.006553863640874624,
0.006387223489582539,
-0.0412607304751873,
0.0010811537504196167,
-0.02482638508081436,
0.014865692704916,
-0.011467427015304565,
0.004099272657185793,
0.009938541799783707,
-0.0007995418272912502,
0.018680494278669357,
-0.004644240252673626,
-0.004469454288482666,
0.006211945321410894,
-0.016415338963270187,
0.003957388922572136,
0.00926082581281662,
-0.0067711081355810165,
-0.011814047582447529,
0.027504822239279747,
0.008532512001693249,
-0.00488045671954751,
0.007043119054287672,
0.024698354303836823,
0.016403332352638245,
-0.013231368735432625,
0.012844202108681202,
0.015453502535820007,
0.012597216293215752,
-0.0059900712221860886,
-0.015228042379021645,
-0.05524083971977234,
0.019337302073836327,
0.008130460046231747,
-0.021322589367628098,
-0.020730936899781227,
0.00241498788818717,
0.012079410254955292,
-0.00919860415160656,
-0.0054858168587088585,
-0.0016985521651804447,
-0.01288699358701706,
0.0009722677059471607,
-0.008019564673304558,
-0.0015685082180425525,
-0.011075196787714958,
-0.004289831034839153,
-0.02320224978029728,
-0.028554346412420273,
0.027424223721027374,
-0.0038277313578873873,
-0.006670798175036907,
0.005531649105250835,
0.007116824388504028,
-0.0032561691477894783,
-0.01594899594783783,
-0.010365893132984638,
0.02345563843846321,
-0.007928069680929184,
0.026134025305509567,
-0.01568622887134552,
0.005500078201293945,
0.008668117225170135,
-0.010472096502780914,
0.007763323374092579,
-0.01462925598025322,
-0.022415298968553543,
0.030061140656471252,
-0.003480380168184638,
0.0159936361014843,
0.008441059850156307,
0.0011157139670103788,
-0.011629251763224602,
0.005333203822374344,
-0.011492261663079262,
-0.0320393331348896,
0.0174143947660923,
-0.008056363090872765,
-0.013046035543084145,
-0.007527497131377459,
-0.00633863965049386,
0.03641035407781601,
0.003273569978773594,
0.0005469890311360359,
-0.01019360776990652,
0.012671075761318207,
0.0056175715290009975,
0.002363841515034437,
-0.0032836860045790672,
0.07151894271373749,
0.019738629460334778,
0.010045316070318222,
-0.03100849874317646,
0.021217230707406998,
-0.03685889393091202,
-0.004871584475040436,
0.022506020963191986,
0.008097830228507519,
-0.028452705591917038,
0.014445288106799126,
-0.03471064940094948,
0.01736525259912014,
-0.021879255771636963,
0.0015372205525636673,
0.006773973815143108,
0.014517759904265404,
0.022289767861366272,
0.02210085093975067,
-0.0040696850046515465,
0.0020683682523667812,
0.006059467326849699,
-0.02413925528526306,
0.03950739651918411,
-0.009326204657554626,
-0.009773625992238522,
0.01241597905755043,
-0.0148523710668087,
0.004152224864810705,
0.01145930215716362,
0.020736925303936005,
-0.006448050960898399,
-0.007773980498313904,
0.013065408915281296,
0.0022883780766278505,
0.017830263823270798,
-0.0009508319199085236,
0.01302220206707716,
-0.006381823215633631,
-0.028666574507951736,
-0.0382133424282074,
-0.009149102494120598,
-0.029027443379163742,
0.010175878182053566,
-0.009565146639943123,
0.046361662447452545,
0.03275798633694649,
-0.004245595540851355,
-0.02882632240653038,
0.011461831629276276,
-0.009171813726425171,
0.0005539432168006897,
0.01468980498611927,
0.006069437600672245,
0.0023755310103297234,
0.013526173308491707,
0.004414530470967293,
-0.004620448220521212,
0.007231691386550665,
-0.009321901947259903,
-0.019249428063631058,
-0.013619892299175262,
-0.016375983133912086,
-0.0145016610622406,
0.00689057819545269,
-0.009967708960175514,
-0.018259501084685326,
-0.004501359537243843,
-0.03345067799091339,
0.010285831987857819,
0.02468409761786461,
-0.005233391188085079,
0.0023101093247532845,
-0.01802871935069561,
-0.0354999378323555,
0.011356806382536888,
-0.026352722197771072,
0.006942301988601685,
-0.04233136773109436,
0.011021411046385765,
-0.0021437848918139935,
0.010078079998493195,
-0.008247814141213894,
-0.024492625147104263,
0.004116946831345558,
-0.018503384664654732,
-0.019391316920518875,
-0.07445007562637329,
-0.018153030425310135,
0.0044908118434250355,
-0.0036394265480339527,
0.014666926115751266,
0.0174599327147007,
-0.012897901237010956,
0.03172693029046059,
0.015668204054236412,
-0.019833531230688095,
0.015781573951244354,
-0.011351036839187145,
0.03111225552856922,
0.0077592735178768635,
0.016890212893486023,
0.03290512412786484,
-0.018070299178361893,
0.016608241945505142,
-0.019870322197675705,
0.01703236810863018,
0.015253330580890179,
0.0165543332695961,
-0.043627794831991196,
0.0015280157094821334,
-0.014100591652095318,
-0.08033661544322968,
0.0034168967977166176,
-0.00039323093369603157,
-0.0096853943541646,
0.004751051776111126,
-0.001645178534090519,
0.05431752651929855,
-0.02429606206715107,
-0.03331182897090912,
-0.01624809205532074,
-0.007186293136328459,
-0.008801049552857876,
0.008360322564840317,
0.008549625054001808,
0.008297472260892391,
-0.007564074359834194,
0.013829542323946953,
-0.021884271875023842,
0.021207353100180626,
0.02454317733645439,
0.018998341634869576,
0.0317559577524662,
-0.0024241269566118717,
-0.013912353664636612,
-0.010314840823411942,
-0.02477646991610527,
-0.031754545867443085,
0.004693657159805298,
-0.01153666339814663,
-0.03231298178434372,
0.016916798427700996,
-0.03276471048593521,
-0.003823690116405487,
0.015030112117528915,
0.028254276141524315,
-0.029054999351501465,
-0.0013356143608689308,
-0.006360957399010658,
0.03138360008597374,
0.007278143428266048,
-0.008557356894016266,
0.0349721722304821,
0.005564748775213957,
-0.003881487064063549,
0.0020844023674726486,
-0.006334610749036074,
0.011626951396465302,
-0.01113741472363472,
0.02829483523964882,
0.009308487176895142,
-0.005608057603240013,
-0.009726453572511673,
0.013655620627105236,
-0.0023255052510648966,
0.014557447284460068,
-0.02716413512825966,
-0.006959321442991495,
0.02432376891374588,
0.02416788786649704,
0.010051608085632324,
0.0014264853671193123,
0.006029094103723764,
0.018240034580230713,
0.07061298191547394,
-0.04100523889064789,
-0.006809183396399021,
-0.012759935110807419,
-0.02519530989229679,
0.0012915675761178136,
-0.018874701112508774,
0.017144735902547836,
-0.030624665319919586,
-0.022500982508063316,
0.007669585291296244,
0.004075089935213327,
-0.007556380704045296,
0.009230803698301315,
0.02705163136124611,
-0.00421238224953413,
0.008816322311758995,
0.013213397935032845,
-0.04496143385767937,
-0.022868013009428978,
-0.013230033218860626,
0.012316962704062462,
0.002452741377055645,
0.003677511354908347,
0.02257581800222397,
-0.00891715008765459,
0.0021111867390573025,
0.013669153675436974,
0.016312215477228165,
0.017346307635307312,
-0.010570842772722244,
0.011658603325486183,
0.008894843980669975,
-0.02816743403673172,
0.0329401008784771,
-0.022097188979387283,
-0.0007111127488315105,
0.019490763545036316,
0.01057145930826664,
0.034459274262189865,
0.014795731753110886,
0.021718479692935944,
0.014625958167016506,
0.014544293284416199,
0.020090317353606224,
-0.022327477112412453,
-0.005405835807323456,
0.026545831933617592,
0.0008107149042189121,
-0.004956536926329136,
0.0068701342679560184,
0.008303181268274784,
0.019970927387475967,
-0.009471973404288292,
-0.0016580820083618164,
-0.009699709713459015,
-0.007671641185879707,
0.03087775595486164,
0.008948156610131264,
0.006808146834373474,
0.01445345114916563,
-0.00805710256099701,
-0.022969011217355728,
-0.01901942677795887,
0.008728555403649807,
0.00829324871301651,
0.02299157716333866,
-0.03422057628631592,
0.027471553534269333,
0.003761044703423977,
-0.007220578379929066,
0.03211658447980881,
0.005810865201056004,
0.0007280916906893253,
0.022967910394072533,
0.02267416939139366,
0.03533750772476196,
-0.003758692415431142,
0.018170645460486412,
0.00859032105654478,
-0.02000398561358452,
-0.024741392582654953,
0.015598267316818237,
-0.015667935833334923,
-0.01091536320745945,
0.011780505999922752,
0.023261934518814087,
-0.01862390898168087,
-0.012947862967848778,
0.001499165315181017,
-0.010341925546526909,
-0.0005019883974455297,
0.002143431920558214,
-0.0019579981453716755,
0.010557357221841812,
0.035456202924251556,
0.013710753992199898,
0.012474628165364265,
0.020314441993832588,
0.009285137988626957,
0.0021459569688886404,
-0.029772035777568817,
0.014742950908839703,
-0.007813705131411552,
-0.01046471856534481,
-0.005304016172885895,
-0.0019858148880302906,
0.012182125821709633,
0.003540600184351206,
0.020068354904651642,
0.002529833698645234,
0.026783250272274017,
-0.0038765640929341316,
-0.022006379440426826,
0.014306532219052315,
-0.0011461637914180756,
-0.013308057561516762,
-0.010031437501311302,
0.0005559325218200684,
-0.01835504174232483,
-0.00014203623868525028,
-0.018165897578001022,
-0.027756156399846077,
0.03658807650208473,
0.01958424597978592,
-0.01565919630229473,
0.00001918780617415905,
-0.005812261253595352,
-0.03968976065516472,
0.0066355252638459206,
0.018548686057329178,
-0.0017095631919801235,
0.006332465447485447,
0.01229653600603342,
-0.003860183758661151,
-0.008945723995566368,
0.0018066361080855131,
0.006568236276507378,
0.010015632957220078,
-0.02785252220928669,
0.006909584626555443,
-0.014187563210725784,
0.008677894249558449,
-0.01320483535528183,
0.012375043705105782,
-0.008093447424471378,
0.0023767370730638504,
0.041428979486227036,
0.009163632988929749,
-0.0078030480071902275,
0.013289880938827991,
0.0010330420918762684,
0.0098405247554183,
-0.0032981301192194223,
-0.013857599347829819,
-0.009601445868611336,
0.03201271966099739,
-0.02278047427535057,
0.018660468980669975,
0.021345240995287895,
-0.015103242360055447,
0.03097476065158844,
-0.0018875864334404469,
-0.0015782760456204414,
-0.0007835477590560913,
-0.010404416359961033,
0.01429007574915886,
0.023227334022521973,
0.0013903900980949402,
-0.0018537648720666766,
-0.01547827199101448,
-0.009517449885606766,
-0.010522750206291676,
0.03238353133201599,
-0.031945906579494476,
-0.008681584149599075,
-0.01198544166982174,
0.023686764761805534,
-0.017521526664495468,
0.015869420021772385,
0.008004497736692429,
0.012160729616880417,
0.00728026544675231,
-0.01626257598400116,
0.004174456000328064,
-0.007911923341453075,
-0.019389105960726738,
0.012335620820522308,
0.0038892587181180716,
0.02246882952749729,
-0.0069902618415653706,
-0.00829042587429285,
-0.006072463933378458,
-0.009358207695186138,
-0.006019980646669865,
-0.0034359898418188095,
-0.034431979060173035,
-0.03093641623854637,
0.01401287131011486,
0.014236901886761189,
-0.0015040161088109016,
0.01296379417181015
] | [
0.36804890632629395,
-0.05524902045726776,
-0.4049818813800812,
-0.2792276442050934,
-0.002804643241688609,
0.3668340742588043,
0.3505565822124481,
0.6456881165504456,
-0.47735273838043213,
-0.5938503742218018,
0.1968117207288742,
-0.29726678133010864,
-0.5058286190032959,
0.34198522567749023,
0.09678063541650772,
0.37126651406288147,
0.296739399433136,
0.3555215001106262,
-0.14597322046756744,
-0.17525127530097961,
-0.5423079133033752,
-0.47274407744407654,
0.08567168563604355,
0.34040066599845886,
0.06520723551511765,
0.043913260102272034,
0.46151143312454224,
-0.15805813670158386,
0.42387911677360535,
-0.05957695469260216,
-0.10022059828042984,
0.684723973274231,
0.16555529832839966,
-0.2563508152961731,
-0.20060186088085175,
-0.2669425308704376,
-0.36515751481056213,
0.104468435049057,
0.05577104166150093,
-0.08706497400999069,
-0.3260040879249573,
-0.4403172731399536,
-0.362748920917511,
0.4122764468193054,
-0.057815488427877426,
-0.6140190958976746,
-1.0989127159118652,
1.0738157033920288,
-0.30003467202186584,
0.2960330545902252,
0.30151796340942383,
-0.005941429641097784,
-0.15430471301078796,
0.1474803388118744,
-0.15893079340457916,
-0.03593035414814949,
-0.30602192878723145,
-0.025566941127181053,
0.2660452723503113,
-0.2649771273136139,
0.07687385380268097,
-0.41151875257492065,
0.08061525225639343,
0.29822736978530884,
-0.3124932050704956,
0.6392792463302612,
0.41879695653915405,
0.7701444029808044,
0.23222960531711578,
-0.547123908996582,
0.0023146988824009895,
-0.31570619344711304,
-0.330717533826828,
0.07909590750932693,
-0.07518541812896729,
0.030880196020007133,
0.1023733839392662,
-0.22469432651996613,
0.14510518312454224,
0.18645180761814117,
-0.18130816519260406,
0.11986878514289856,
0.4143367409706116,
-0.6527610421180725,
0.5384367108345032,
0.05590454488992691,
0.21438603103160858,
0.5200110673904419,
-0.00535332877188921,
-0.09952229261398315,
0.08907302469015121,
-0.2830772399902344,
0.58111172914505,
0.5326241850852966,
-0.2069379985332489,
0.23097245395183563,
-0.013524935580790043,
0.08462004363536835,
0.2490113228559494,
-0.19745895266532898,
-0.592573344707489,
-0.11497163772583008,
0.15366269648075104,
-0.08220481872558594,
-0.29826462268829346,
0.1084815263748169,
0.18656955659389496,
-0.3023717403411865,
-0.6353038549423218,
-0.1152493879199028,
-0.07180558145046234,
0.02586832456290722,
-0.2099170684814453,
-0.24559201300144196,
-0.35936009883880615,
0.5354264378547668,
0.5093505382537842,
-0.5730225443840027,
0.32006338238716125,
-0.2786271572113037,
-0.45904120802879333,
0.5991618633270264,
-0.08120033144950867,
0.43004176020622253,
-0.0981195867061615,
0.172005295753479,
0.31666266918182373,
-0.1509450227022171,
-0.04824081435799599,
0.5711809396743774,
0.08075254410505295,
0.5870080590248108,
0.030639933422207832,
0.1222437173128128,
0.16351424157619476,
-0.043460432440042496,
-0.011865208856761456,
0.4651937186717987,
0.15663853287696838,
-0.3751983642578125,
-0.6220910549163818,
-0.5561385750770569,
-0.4517810046672821,
-0.03609992936253548,
0.2861265242099762,
-0.16521522402763367,
-0.2311239391565323,
-0.1951592117547989,
-0.18369802832603455,
-0.5397506952285767,
0.14484037458896637,
-0.5126069784164429,
-0.5410349369049072,
-0.29353418946266174,
0.01757012866437435,
0.07644958049058914,
-0.2991061210632324,
0.07978116720914841,
0.0681343600153923,
0.25360333919525146,
0.6183086633682251,
0.5609465837478638,
-0.12966710329055786,
-0.045873746275901794,
0.2990776300430298,
-0.12959273159503937,
0.19044484198093414,
0.2744702100753784,
-0.43002501130104065,
-0.056665897369384766,
-0.26076552271842957,
-0.2654835283756256,
0.17242076992988586,
-0.33111676573753357,
-0.01005492266267538,
-0.0370505191385746,
0.42535507678985596,
-0.5818026661872864,
0.22848908603191376,
0.13779649138450623,
-0.3904576599597931,
0.1919233351945877,
0.4565346837043762,
-0.16959168016910553,
-0.11469287425279617,
-0.02690041996538639,
0.023912811651825905,
0.1930210143327713,
0.3490183651447296,
-0.06297160685062408,
-0.07402223348617554,
-0.3603286147117615,
0.6222951412200928,
-0.5298075675964355,
1.3801724910736084,
-0.505395233631134,
-0.19724488258361816,
1.2152036428451538,
0.5016792416572571,
0.20968875288963318,
0.12341335415840149,
-0.05720078945159912,
0.9542921185493469,
-0.4610220193862915,
-0.8548500537872314,
-0.02497040294110775,
-0.004268794320523739,
-0.1735365092754364,
-0.14387191832065582,
-0.2953328490257263,
0.4839145243167877,
-0.018841983750462532,
-0.18749970197677612,
0.05873624235391617,
0.18633440136909485,
0.48107701539993286,
-0.11736518889665604,
-0.1751163750886917,
0.18924963474273682,
-0.3719538450241089,
0.0362674780189991,
-0.7934210300445557,
-0.036934319883584976,
0.07846482843160629,
0.0959969013929367,
0.4961552321910858,
0.5903146266937256,
-0.2030792236328125,
0.7178280353546143,
-0.913776695728302,
0.4106728136539459,
-0.20860646665096283,
0.26419463753700256,
-0.8134124875068665,
-0.3029535114765167,
-0.035551123321056366,
0.0805116817355156,
0.05108589306473732,
0.02050098590552807,
0.22756531834602356,
0.4054989218711853,
0.41178107261657715,
-0.5622478723526001,
-0.3043209910392761,
-0.12650363147258759,
-0.45352426171302795,
0.2513193190097809,
-0.3590032458305359,
-0.621143102645874,
0.14402273297309875,
0.05028487369418144,
0.2657497525215149,
0.05924275889992714,
-0.36978498101234436,
0.10886995494365692,
0.18855251371860504,
0.2520531415939331,
-0.4050333499908447,
0.46791520714759827,
0.08167758584022522,
0.250973641872406,
-0.18462912738323212,
0.2067868411540985,
0.6025391221046448,
0.23563335835933685,
-0.6920362710952759,
-0.2227778136730194,
-0.5391489267349243,
0.5620373487472534,
0.46465781331062317,
0.9647695422172546,
0.25752750039100647,
-0.0377911701798439,
0.10888735949993134,
0.4317184090614319,
-0.7625719904899597,
0.5246156454086304,
0.7980558276176453,
-0.5683233141899109,
-0.2206510752439499,
-0.3065277636051178,
-0.044520750641822815,
0.6520352959632874,
-0.6956288814544678,
0.44573429226875305,
-0.8359513282775879,
0.029142951592803,
-0.19075976312160492,
-0.7130149602890015,
0.5592972040176392,
0.07096696645021439,
0.13316603004932404,
-0.2682923674583435,
-0.012402708642184734,
-0.09024430811405182,
-0.2241286188364029,
0.2550998330116272,
0.5581596493721008,
0.5804174542427063,
-0.11662972718477249,
-0.047040924429893494,
0.10104294121265411,
-0.3643660545349121,
-0.19873066246509552,
-0.28844866156578064,
0.4090574085712433,
-0.140223890542984,
-0.20797383785247803,
-5.919546604156494,
0.42330795526504517,
-0.0417904406785965,
-0.6486268043518066,
-0.5253329277038574,
0.23714594542980194,
0.9755107760429382,
0.2923559248447418,
0.4898345470428467,
0.11011341214179993,
0.6531603336334229,
0.40507420897483826,
0.22060978412628174,
-0.4109311103820801,
-0.4170626401901245,
-0.44155943393707275,
0.08315373212099075,
-0.170687735080719,
0.044192660599946976,
0.33683520555496216,
-0.3895663917064667,
-0.5013041496276855,
0.20717570185661316,
0.5043690204620361,
0.20920220017433167,
0.21823421120643616,
-0.9772045016288757,
0.23394328355789185,
0.005099066067487001,
0.10146268457174301,
0.4614752233028412,
-1.1946362257003784,
-0.04446631669998169,
-0.10973073542118073,
-0.39060142636299133,
-0.26491570472717285,
0.2011965960264206,
-0.4069673717021942,
-0.2476322054862976,
-0.2693783640861511,
0.07342302799224854,
0.03697686642408371,
-0.01405801996588707,
-0.683346688747406,
0.2605261504650116,
0.027084380388259888,
0.23646613955497742,
0.19117683172225952,
-0.06383685022592545,
0.5904147624969482,
0.10775087773799896,
0.14858639240264893,
-0.04290635511279106,
0.6259167194366455,
0.4341583549976349,
0.1873476207256317,
0.12004771828651428,
0.06283204257488251,
-0.2865311801433563,
0.2506410777568817,
0.26565980911254883,
0.01151208020746708,
0.24995210766792297,
-0.17078295350074768,
0.2615409791469574,
-0.1425495594739914,
-0.882250189781189,
-0.1825704723596573,
0.14719487726688385,
-0.11126937717199326,
-0.12475942075252533,
0.1724587380886078,
0.2270607352256775,
-0.9001978039741516,
-0.14617851376533508,
-0.6481762528419495,
0.11841357499361038,
-0.24428819119930267,
0.03006790764629841,
-0.4152742028236389,
-0.30894458293914795,
-0.06684546172618866,
0.29606321454048157,
-0.2613315284252167,
0.11251993477344513,
0.13721902668476105,
-0.2943755090236664,
-0.0077424137853085995,
-0.15868011116981506,
-0.30753859877586365,
0.9313048124313354,
-0.5559992790222168,
0.09026682376861572,
0.12857915461063385,
0.2356574982404709,
0.6712422370910645,
0.5411761999130249,
0.3234783113002777,
0.4137308895587921,
0.400523841381073,
1.03745436668396,
-0.3283942639827728,
-0.4925854802131653,
-1.1655471324920654,
-0.10333427041769028,
-0.2715502381324768,
-0.697275698184967,
-0.057498231530189514,
0.9982278347015381,
-0.8381869196891785,
-0.1955004632472992,
-0.24638298153877258,
-0.30079975724220276,
0.013633816502988338,
0.6974635720252991,
-0.08433976769447327,
0.17639826238155365,
0.11991852521896362,
0.8089783191680908,
-0.18177218735218048,
0.3689170479774475,
0.44389843940734863,
-0.5723320245742798,
0.8404091000556946,
0.5898457169532776,
-0.4241533875465393,
0.14280319213867188,
0.3199033737182617,
-0.6972463726997375,
-0.7011498212814331,
0.3030625879764557,
0.22416414320468903,
-0.4246430993080139,
-0.11438068747520447,
0.38685327768325806,
0.06068762019276619,
-0.5263023376464844,
-0.29420167207717896,
0.5255216360092163,
0.30627691745758057,
-0.20697136223316193,
-0.03045031428337097,
-0.09132027626037598,
0.21202056109905243,
0.6772849559783936,
-0.040461767464876175,
-0.029699664562940598,
-0.059505678713321686,
-0.3063594102859497,
-0.30919820070266724,
0.27018681168556213,
0.06379903107881546,
0.23719632625579834,
0.09751343727111816,
-1.0528815984725952,
0.2442145198583603,
0.762443482875824,
0.06525713950395584,
-0.35617583990097046,
-0.2881196439266205,
0.47137191891670227,
-0.23378980159759521,
-0.6984214186668396,
-0.2008102536201477,
-0.05298629775643349,
-0.42783471941947937,
0.505240261554718,
-0.20912215113639832,
0.1638234257698059,
-0.16374173760414124,
-0.16959692537784576,
-0.5081199407577515,
0.09526592493057251,
0.19411933422088623,
0.010518324561417103,
0.1208229809999466,
-0.5404388308525085,
0.088955357670784,
-0.15617817640304565,
0.4984835088253021,
0.09796874970197678,
-0.08726134151220322,
-0.6364871859550476,
0.43894052505493164,
0.8079800009727478,
0.5701845288276672,
0.13761937618255615,
0.043461889028549194,
-0.2715366780757904,
-0.1567182093858719,
0.3431274890899658,
-0.1420155167579651,
0.04904148727655411,
0.08424632996320724,
-0.3891282379627228,
-0.39354652166366577,
-0.3295053541660309,
0.05139894410967827,
-0.3161492943763733,
-0.20138783752918243,
-0.004246898926794529,
0.4007870852947235,
-0.20030003786087036,
0.2094535231590271,
0.31516188383102417,
-0.4202684760093689,
-0.20825567841529846,
-0.21753853559494019,
0.02630872093141079,
-0.4814440906047821,
0.21134832501411438,
-0.2096865475177765,
-0.434114545583725,
0.5982003211975098,
0.04453668370842934,
0.20150233805179596,
-0.10819292813539505,
-0.3958686590194702,
0.048779554665088654,
0.07679519802331924,
-0.09613226354122162,
0.2834748923778534,
0.12149900197982788,
-0.1200331524014473,
0.07449302077293396,
0.8134746551513672,
0.3795762062072754,
-0.7878147959709167,
-0.1260346621274948,
-0.05260942131280899,
-0.22293038666248322,
0.017589541152119637,
0.35695865750312805,
0.4091884195804596,
-0.8832176327705383,
-0.03075157292187214,
0.2582954466342926,
-0.47388744354248047,
0.22543585300445557,
0.7462169528007507,
0.21894571185112,
0.20617716014385223,
0.02438417077064514,
-0.517243504524231,
0.2968972325325012,
-0.07371804863214493,
0.1460583657026291,
-0.3595172166824341,
-0.059029076248407364,
0.3668420910835266,
-0.1904660314321518,
-0.4547181725502014,
-0.021502472460269928,
0.1751108169555664,
0.6210079789161682,
0.02491888403892517,
-0.1970345675945282,
-0.3055552840232849,
-0.22409045696258545,
-0.19429334998130798,
-0.1950986683368683,
-0.5873513221740723,
-0.22690457105636597,
0.045319970697164536,
-0.25822582840919495,
-0.5436387658119202,
-0.7215938568115234,
-0.14385390281677246,
-0.04301005229353905,
-0.2818221151828766,
0.03505956381559372,
0.06349621713161469,
0.40338972210884094,
0.3815217614173889,
-0.12069817632436752,
0.56526780128479,
-0.3922577202320099,
0.30426567792892456,
-0.6712963581085205,
0.17895454168319702,
-0.7380074262619019,
-0.5734450817108154,
0.09975805878639221,
-0.19999660551548004,
0.1367618888616562,
-0.37545517086982727,
0.28139233589172363,
-0.4179246723651886,
-0.054648593068122864,
-0.9257543683052063,
-0.20971302688121796,
0.1605379283428192,
-0.17362283170223236,
-0.30445024371147156,
0.08099483698606491,
0.21111592650413513,
0.1713508665561676,
0.8045293092727661,
0.24628178775310516,
-0.27372175455093384,
-0.5981574058532715,
0.8657210469245911,
0.11853332817554474,
-0.6131561994552612,
-0.05327045917510986,
-0.08143560588359833,
0.34846699237823486,
0.34046709537506104,
-0.1143343597650528,
0.05450667813420296,
0.474158376455307,
0.10247670859098434,
0.2816469669342041,
0.1643916517496109,
-0.6109746098518372,
0.3697088956832886,
-0.345486581325531,
-0.8932614922523499,
0.5718316435813904,
-0.4341332018375397,
0.006452654022723436,
0.9078533053398132,
0.2958912253379822,
0.02231568470597267,
-0.3744003176689148,
0.7505643367767334,
0.014947062358260155,
0.6172444224357605,
-0.07088901102542877,
0.19909577071666718,
0.3458183705806732,
-0.09138895571231842,
-0.49591264128685,
0.12962770462036133,
-0.17158959805965424,
0.21641194820404053,
0.13537810742855072,
-0.633085310459137,
-0.24775321781635284,
-0.11283544450998306,
0.9688147902488708,
0.30525532364845276,
0.1509900838136673,
-0.054046567529439926,
0.11213956773281097,
0.16398002207279205,
0.12728020548820496,
0.182130828499794,
0.2733810544013977,
0.24798938632011414,
0.27699896693229675,
-0.43730536103248596,
-0.13172708451747894,
0.3648686408996582,
-0.09467361122369766,
-0.04805097356438637,
0.009901829063892365,
-0.10066377371549606,
-0.8851819634437561,
-0.1908869594335556,
0.010617339983582497,
0.009360603988170624,
0.32117635011672974,
0.5076618790626526,
-0.286312073469162,
-0.00023639925348106772,
0.419085294008255,
0.4130977988243103,
-0.331119567155838,
-0.457857608795166,
0.15474312007427216,
-0.29679039120674133,
-0.2475406974554062,
0.06602110713720322,
0.3176761269569397,
-0.12868697941303253,
0.04537496343255043,
0.21099631488323212,
0.07284680008888245,
0.32094404101371765,
-0.24899791181087494,
-0.11777262389659882,
0.15403395891189575,
-0.0501733236014843,
0.01858253963291645,
-0.20704059302806854,
-0.40362510085105896,
0.18370631337165833,
0.10839854925870895,
-0.3579951226711273,
-0.008885622955858707,
-0.7085568308830261,
0.426700234413147,
0.6657208800315857,
0.11556538194417953,
-0.07934202253818512,
0.21021324396133423,
0.7551511526107788,
-0.005085970275104046,
0.5428661704063416,
0.0592181421816349,
-0.17251619696617126,
-0.1927255392074585,
0.3554750978946686,
-0.502407431602478,
0.7596541047096252,
-0.3857775926589966,
-0.3124812841415405,
-0.4215315580368042,
0.31429100036621094,
0.6057759523391724,
0.12168563902378082,
-0.26647451519966125,
0.1535954475402832,
-0.40255796909332275,
-0.06389005482196808,
0.4812120199203491,
-0.20753362774848938,
-0.36244526505470276,
-0.6817448139190674,
-0.20766016840934753,
-0.6540118455886841,
-0.020880231633782387,
-0.0034716487862169743,
-0.22737783193588257,
-0.09232182055711746,
0.31307682394981384,
0.7647148370742798,
0.012179426848888397,
0.6837428212165833,
-0.13128192722797394,
-0.07182423770427704,
-0.3508479595184326,
0.3690621852874756,
-0.47198495268821716,
0.018707647919654846,
0.5813170075416565,
0.367279976606369,
0.022398395463824272,
-0.1321081966161728,
0.20501533150672913,
-0.2644807994365692,
0.10968147963285446,
-0.06140894442796707,
0.0881219208240509,
0.5092387795448303,
-0.13548098504543304,
-0.058823615312576294,
-0.7767612338066101,
0.24258239567279816,
-0.2829483449459076,
-0.03931056708097458,
-0.004667247179895639,
0.3944157063961029,
-0.23915348947048187,
0.06970443576574326,
0.08876990526914597,
-0.14733636379241943,
-0.23049581050872803,
-0.4365391433238983
] |
[
0.030699975788593292,
0.10140369832515717,
-0.04192632809281349,
0.06293141841888428,
-0.03267847001552582,
-0.12038351595401764,
0.035765983164310455,
-0.05915536358952522,
-0.008488839492201805,
-0.05911063775420189,
-0.05657084658741951,
-0.005575065966695547,
-0.05070307105779648,
0.06654473394155502,
-0.05232572928071022,
-0.10524960607290268,
-0.11025319993495941,
0.10980250686407089,
0.11460278183221817,
-0.11366231739521027,
-0.0736834928393364,
-0.014200853183865547,
0.03315950185060501,
-0.042415086179971695,
-0.18886972963809967,
0.04834016412496567,
-0.010257190093398094,
-0.013155662454664707,
-0.11621294915676117,
0.22128282487392426,
0.026432644575834274,
-0.0035340951289981604,
0.09944672882556915,
0.0506606251001358,
0.07618589699268341,
-0.1337132453918457,
-0.07806193083524704,
0.018981769680976868,
-0.056862808763980865,
-0.14643901586532593,
-0.16388945281505585,
-0.057634275406599045,
0.07937344908714294,
-0.0544847771525383,
-0.024052107706665993,
-0.07310523092746735,
-0.07155387103557587,
-0.10090649873018265,
-0.028452187776565552,
0.14460046589374542,
-0.05908972769975662,
-0.0028850892558693886,
-0.030829090625047684,
-0.06325825303792953,
-0.02312028780579567,
-0.15990810096263885,
-0.09092682600021362,
-0.016466086730360985,
0.06645786762237549,
0.04531364515423775,
-0.11512433737516403,
0.10278821736574173,
-0.23874814808368683,
-0.08993463963270187,
0.04214683547616005,
-0.06208702549338341,
0.19159553945064545,
0.06058281660079956,
0.04147198423743248,
0.04145164415240288,
0.08241380751132965,
0.07910601049661636,
-0.21460114419460297,
-0.04764945060014725,
-0.06004532054066658,
-0.05771621689200401,
0.04311008378863335,
0.029352186247706413,
-0.007787349633872509,
0.0667465552687645,
0.11730451881885529,
-0.036040034145116806,
0.0379948653280735,
0.08618149906396866,
0.09119251370429993,
-0.12663358449935913,
-0.027850864455103874,
-0.026794370263814926,
0.10444615036249161,
-0.19966867566108704,
-0.06711355596780777,
0.020024478435516357,
0.02054487355053425,
-0.07212473452091217,
-0.12159039080142975,
-0.23648804426193237,
-0.04011392965912819,
0.10453135520219803,
-0.08162038028240204,
-0.047898195683956146,
-0.14109919965267181,
-0.09871640801429749,
0.006453124340623617,
0.08454540371894836,
-0.20008768141269684,
0.031001994386315346,
0.3166082501411438,
-0.08357764780521393,
-0.06154737249016762,
0.05468873679637909,
-0.10438451170921326,
-0.043026577681303024,
0.039880186319351196,
-0.002967559266835451,
0.04125188663601875,
0.10730873048305511,
-0.031131744384765625,
0.07599066942930222,
0.11015765368938446,
0.2026078850030899,
0.0340835340321064,
-0.11498764902353287,
0.00341621832922101,
0.1823115050792694,
0.08721653372049332,
0.08886470645666122,
0.038886621594429016,
-0.14626866579055786,
-0.10826382040977478,
-0.10755138099193573,
-0.043079130351543427,
0.06791600584983826,
-0.08626728504896164,
-0.13008858263492584,
-0.06684456765651703,
-0.0757908821105957,
-0.12930254638195038,
0.10704216361045837,
-0.16803321242332458,
0.12600107491016388,
-0.04051733389496803,
0.056915540248155594,
0.09876076132059097,
0.05756385996937752,
0.12005363404750824,
-0.09532523900270462,
-0.0735682025551796,
0.04351639747619629,
0.12305520474910736,
-0.12239664793014526,
-0.03981996327638626,
-0.02161284163594246,
-0.10828825831413269,
-0.0646689310669899,
-0.03846750035881996,
0.19904725253582,
-0.03407208248972893,
-0.10436071455478668,
0.018596051260828972,
0.10414863377809525,
0.09536723792552948,
-0.014020226895809174,
0.04361536353826523,
0.028888408094644547,
-0.06593406200408936,
0.008343683555722237,
0.04160940647125244,
-0.011753213591873646,
-0.11578797549009323,
0.05167029798030853,
-0.06676144897937775,
0.1441592276096344,
-0.22843779623508453,
0.12496988475322723,
0.028016896918416023,
-0.05906530097126961,
0.17457708716392517,
0.05070481076836586,
-0.11385047435760498,
0.060045935213565826,
-0.09621882438659668,
0.05438654124736786,
0.03432608023285866,
0.15427951514720917,
0.11706224828958511,
-0.002386678010225296,
0.00803310889750719,
-0.07359828799962997,
0.15835100412368774,
0.017626335844397545,
-0.007624693680554628,
-0.04966338351368904,
-0.04089459404349327,
0.07255762070417404,
0.21151596307754517,
0.06603258103132248,
0.09396278113126755,
-0.018833069130778313,
0.02596215531229973,
0.07787297666072845,
0.0033172147814184427,
-0.03406890109181404,
-0.0378173291683197,
0.0016285512829199433,
0.17468418180942535,
0.14436595141887665,
0.07670074701309204,
-0.018170222640037537,
-0.12715241312980652,
0.011177051812410355,
0.04855913668870926,
0.05172306299209595,
-0.04483100771903992,
-0.031188545748591423,
0.21232262253761292,
-0.12014889717102051,
0.04454215243458748,
-0.006694146431982517,
-0.008590037934482098,
0.010534912347793579,
-0.005982778966426849,
-0.049038566648960114,
-0.03788432478904724,
-0.148992121219635,
-0.15680280327796936,
0.11952607333660126,
-0.03443474322557449,
-0.009466748684644699,
-0.17385894060134888,
0.06695250421762466,
-0.08063670247793198,
0.1111515536904335,
-0.05964672192931175,
-0.08919277042150497,
0.07400178909301758,
-0.08179539442062378,
0.010917145758867264,
-0.10002771019935608,
0.030084840953350067,
-0.05879339575767517,
0.15256229043006897,
-0.0588756687939167,
0.058464743196964264,
-0.06250129640102386,
-0.1272299885749817,
0.14816193282604218,
0.11261296272277832,
-0.20878300070762634,
0.07267408818006516,
-0.19025585055351257,
0.04558248072862625,
-0.06399069726467133,
0.09287825971841812,
-0.14967121183872223,
0.0832153856754303,
0.0884755551815033,
-0.07130222767591476,
-0.08636317402124405,
-0.062446922063827515,
-0.0917036235332489,
0.04213356599211693,
0.02685438096523285,
-0.07510712742805481,
0.14564858376979828,
-0.1311965137720108,
0.06008942797780037,
0.10980391502380371,
0.23106127977371216,
0.06301818042993546,
-0.11306808888912201,
0.4958252012729645,
-0.08599810302257538,
-0.10827255249023438,
-0.07431084662675858,
0.00557404151186347,
-0.010929758660495281,
0.19725823402404785,
0.07282532006502151,
0.12956568598747253,
0.12012496590614319,
-0.32143303751945496,
-0.003951505292207003,
0.031411223113536835,
0.2858768403530121,
0.007240592502057552,
-0.04573579132556915,
-0.15110504627227783,
-0.06919705122709274,
-0.05780123919248581,
0.045537661761045456,
0.08062059432268143,
0.05595998466014862,
-0.19111478328704834,
0.20023339986801147,
0.030304836109280586,
0.16707292199134827,
-0.019236214458942413,
0.14964352548122406,
-0.0109718581661582,
0.08966008573770523,
-0.1306983232498169,
-0.10273553431034088,
0.05057602375745773,
-0.10228367894887924,
-0.014037727378308773,
0.01175781711935997,
-0.19365377724170685,
0.07810384780168533,
-0.09055490046739578,
-0.024642886593937874,
-0.007601541467010975,
0.024362703785300255,
0.1254616379737854,
-0.048288214951753616,
0.038688793778419495,
-0.023422805592417717,
-0.039048850536346436,
0.09871713072061539,
-0.12935157120227814,
-0.08097562938928604,
-0.08026036620140076,
0.09477176517248154,
-0.016387617215514183,
0.016990656033158302,
-0.08228129148483276,
-0.013419480063021183,
0.09099746495485306,
-0.12665517628192902,
-0.11556627601385117,
-0.06357208639383316,
0.13796506822109222,
-0.03748014569282532,
-0.06792362779378891,
-0.11707259714603424,
-0.03880562260746956,
0.021529851481318474,
0.1335168182849884,
-0.20159269869327545,
-0.020768262445926666,
0.03235907480120659,
0.17776764929294586,
-0.13711069524288177,
0.054383035749197006,
0.1364498734474182,
-0.0664997398853302,
-0.13668900728225708,
-0.05714643374085426,
0.06318619847297668,
-0.04915833845734596,
-0.037615757435560226,
-0.030773334205150604,
0.16446112096309662,
-0.04886315017938614,
-0.18910305202007294,
0.07617077976465225,
-0.016795340925455093,
0.09917127341032028,
-0.018028702586889267,
0.17936013638973236,
0.1950056403875351,
-0.07366102188825607,
0.06003068387508392,
-0.06908491253852844,
0.010838094167411327,
-0.01070399209856987,
-0.02660319395363331,
0.013416670262813568,
-0.06685419380664825,
-0.02624829299747944,
-0.03683823347091675,
-0.09697310626506805,
-0.18608561158180237,
0.0381377749145031,
0.14146940410137177,
-0.1311713010072708,
0.07777606695890427,
-0.01577705889940262,
-0.17565688490867615,
0.03242841362953186,
0.033038247376680374,
-0.10881786793470383,
-0.11456996947526932,
-0.020494369789958,
0.029386846348643303,
0.09281162917613983,
0.1401824951171875,
0.15178707242012024,
0.040599074214696884,
0.09011775255203247,
-0.24185405671596527,
-0.048800211399793625,
0.0538560152053833,
0.024362187832593918,
0.08835064619779587,
-0.12078657001256943,
-0.029829923063516617,
-0.050800859928131104,
-0.027568737044930458,
0.11569537967443466,
-0.08833982795476913,
-0.07752125710248947,
0.04416066035628319,
0.10488185286521912,
-0.03403449431061745,
-0.036388035863637924,
-0.028469476848840714,
0.00013972366286907345,
-0.02620040997862816,
0.019505295902490616,
0.03172631934285164,
-0.009704504162073135,
-0.008721652440726757,
0.02358195185661316,
-0.02107628993690014,
0.10953398793935776,
-0.12684720754623413,
-0.011352095752954483,
0.20320820808410645,
0.11569026112556458,
0.06384299695491791,
0.07973365485668182,
0.07756686955690384,
-0.014700566418468952,
-0.07601739466190338,
-0.15688274800777435,
0.043123140931129456,
-0.07327551394701004,
0.11937576532363892,
-0.16742980480194092,
-0.06767740845680237,
-0.032997481524944305,
0.03229013830423355,
-0.07201521098613739,
0.020497772842645645,
0.1007266715168953,
0.10656307637691498,
-0.006670929957181215,
0.045204728841781616,
-0.11228744685649872,
0.03726661205291748,
-0.09642747044563293,
-0.021383125334978104,
0.09304244816303253,
0.16754911839962006,
0.046043168753385544,
-0.06674063950777054,
0.05671413242816925,
-0.1691814512014389,
-0.09079419821500778,
0.02362711913883686,
-0.03823481500148773,
0.032727308571338654,
0.027651354670524597,
-0.06272287666797638,
0.25346511602401733,
-0.0711563304066658,
-0.09735190868377686,
0.09871630370616913,
-0.09277880936861038,
0.17078223824501038,
-0.04301628842949867,
-0.12943820655345917,
0.09328215569257736,
-0.03212863951921463,
0.07257618755102158,
-0.0919959545135498,
-0.09690722078084946,
-0.014983730390667915,
-0.02383156679570675,
0.1599690020084381,
0.2708745300769806,
0.004232767503708601,
0.06919010728597641,
-0.18598918616771698,
-0.18889376521110535,
0.12317569553852081,
0.20423759520053864,
-0.018112223595380783,
0.05860372632741928,
0.04035134240984917,
0.23361057043075562,
-0.036147184669971466,
0.09624502807855606,
0.15925373136997223,
-0.05318930000066757,
0.0999671220779419,
-0.1810319870710373,
-0.05631474032998085,
0.24686497449874878,
-0.29344862699508667,
-0.08175241202116013,
-0.1502540409564972,
0.03189156949520111,
-0.21783162653446198,
-0.0316685251891613,
0.0770697370171547,
0.011430091224610806,
-0.20418010652065277,
0.12323997914791107,
-0.05420595780014992,
-0.06644335389137268,
0.017708318307995796,
-0.031245650723576546,
-0.069255530834198,
0.029646968469023705,
-0.010673110373318195,
-0.043574053794145584,
0.04528564214706421,
-0.010181069374084473,
0.17210781574249268,
-0.11144612729549408,
-0.03275112062692642,
-0.01416890136897564,
-0.11918938905000687,
0.16780740022659302,
-0.04347151517868042,
-0.07990653067827225,
-0.1383093297481537,
-0.07701651751995087,
0.13612787425518036,
0.06718118488788605,
-0.03026001900434494,
-0.10584010183811188,
0.1504666954278946,
0.04537953436374664,
-0.04277321323752403,
-0.07999415695667267,
-0.05302651226520538,
0.06232829764485359,
-0.06967832148075104,
0.006939463783055544,
0.03764990344643593,
-0.16889509558677673,
-0.0128104779869318,
-0.12893931567668915,
0.004090023227035999,
-0.10927903652191162,
0.02363210916519165,
-0.0021094942931085825,
0.09061166644096375,
-0.15584534406661987,
0.10387682914733887,
-0.05615909397602081,
-0.08126594126224518,
-0.12864066660404205,
-0.10040390491485596,
0.049997348338365555,
-0.06948837637901306,
-0.2262738049030304,
0.07372745871543884,
-0.0751219317317009,
-0.023589715361595154,
0.0006566792726516724,
0.015917714685201645,
0.015185697935521603,
0.1439286172389984,
-0.048737782984972,
0.04775804653763771,
-0.03251831233501434,
-0.08096536993980408,
0.11022157967090607,
0.08137879520654678,
0.06090184673666954,
-0.00013641569239553064,
-0.08019585907459259,
0.029292188584804535,
0.0633009821176529,
-0.12884356081485748,
0.08761142194271088,
0.026820791885256767,
-0.08458266407251358,
0.07295160740613937,
0.15415427088737488,
-0.0795522928237915,
0.11442394554615021,
0.02001115493476391,
0.09106463938951492,
-0.016615290194749832,
-0.21292705833911896,
0.10298934578895569,
0.05502275377511978,
0.0073677487671375275,
-0.2833021283149719,
0.02874218113720417,
-0.11885728687047958,
0.14102113246917725,
0.07653405517339706,
0.09427811205387115,
-0.18969523906707764,
0.029876410961151123,
0.09227520227432251,
-0.013809707947075367,
-0.19043710827827454,
0.2721906006336212,
-0.09463087469339371,
0.16874489188194275,
-0.0929885283112526,
-0.20977464318275452,
0.11410222947597504,
-0.24532605707645416,
0.1033991351723671,
-0.10767566412687302,
0.1346479207277298,
0.04692460969090462,
-0.06546223908662796,
-0.06456930190324783,
-0.016968602314591408,
-0.17973142862319946,
0.006486006546765566,
0.12100864946842194,
0.16770276427268982,
0.09269894659519196,
-0.02782367542386055,
0.08303628861904144,
-0.01005392987281084,
0.12554210424423218,
-0.0039508226327598095,
0.06577645242214203,
-0.16509583592414856,
0.04058369994163513,
-0.1464710533618927,
0.06944134086370468,
0.004074519500136375,
0.030400428920984268,
-0.23784418404102325,
-0.16445674002170563,
0.17691773176193237,
-0.04592552036046982,
-0.12712617218494415,
-0.0823761522769928,
0.09494348615407944,
0.1738746613264084,
0.09308170527219772,
-0.06952536106109619,
-0.018745578825473785,
0.057547252625226974,
0.07872483134269714,
0.09157146513462067,
0.04403744265437126,
0.016956856474280357,
-0.09269630163908005,
-0.029361916705965996,
-0.06743098795413971,
-0.28720706701278687,
0.07613074034452438,
0.005947081837803125,
-0.04800977557897568,
0.05805841088294983,
-0.22678130865097046,
0.00736323744058609,
-0.036018453538417816,
-0.09721697121858597,
0.21445755660533905,
0.14375033974647522,
-0.037552669644355774,
0.07481253147125244,
0.047465730458498,
0.12795665860176086,
0.0499894879758358,
0.3371717631816864,
0.1206621453166008,
0.04664211347699165,
0.07534867525100708,
0.11638755351305008,
-0.1137082502245903,
-0.01809467002749443,
0.027630813419818878,
-0.07026474177837372,
0.10068340599536896,
-0.033441174775362015,
-0.02745586819946766,
-0.09059090167284012,
-0.016674429178237915,
-0.09251946210861206,
-0.1066908910870552,
-0.14217059314250946,
-0.0029501612298190594,
-0.10616209357976913,
-0.12213589251041412,
0.23970355093479156,
-0.06059916317462921,
0.09325772523880005,
-0.027130169793963432,
0.08298519998788834,
-0.11706145107746124,
-0.025369465351104736,
0.02586756832897663,
-0.10644304752349854,
0.07422038167715073,
0.011267676949501038,
0.040812499821186066,
0.11823710054159164,
-0.12311052531003952,
0.036918528378009796,
-0.09282504767179489,
-0.07867162674665451,
0.09925122559070587,
0.00831183698028326,
0.07572954893112183,
0.18012267351150513,
-0.11015387624502182,
0.25394564867019653,
0.0647750273346901,
-0.010540131479501724,
-0.14140892028808594,
0.09216330945491791,
0.14021435379981995,
-0.07399103045463562,
0.030010830610990524,
-0.0632258877158165,
0.026569640263915062,
-0.31273141503334045,
0.09507186710834503,
0.048706747591495514,
0.03564697876572609,
0.0877167135477066,
0.044927213340997696,
0.0967792421579361,
-0.12211425602436066,
-0.1670200675725937,
0.09019871801137924,
0.036771178245544434,
-0.01080002449452877,
0.07695483416318893,
0.17063258588314056,
0.04803616926074028,
-0.10535462200641632,
0.06133848801255226,
0.10331029444932938,
-0.0652971938252449,
0.12990865111351013,
0.06802456825971603,
0.031069843098521233,
-0.06295310705900192,
-0.0010956355836242437,
-0.042811691761016846,
0.05890437588095665,
-0.03734767809510231,
-0.0005172397359274328,
0.023220261558890343,
-0.13965068757534027,
-0.07897917926311493,
-0.0788731500506401,
0.023132644593715668,
0.04229813814163208,
0.0890314057469368,
-0.07917604595422745,
-0.03219835087656975,
0.1405557245016098,
-0.03651417791843414,
-0.04889789968729019,
0.03253275156021118,
-0.08247864246368408,
-0.03458242863416672,
-0.04264979436993599,
-0.04301273822784424,
-0.09590031951665878,
0.13572357594966888,
0.0012255808105692267,
0.16827429831027985,
0.0843420997262001,
-0.09352738410234451,
0.03125839680433273,
-0.28809845447540283,
0.08971253037452698,
-0.049394357949495316,
0.11219234764575958,
-0.16251173615455627
] | [
-0.6405137181282043,
-0.40237531065940857,
-0.4379032552242279,
0.4858168959617615,
0.026843443512916565,
0.8250871896743774,
0.591051459312439,
0.49869590997695923,
-0.05352409556508064,
-0.5380819439888,
-0.030063176527619362,
0.1934276521205902,
-0.17665459215641022,
-0.2884982228279114,
0.21587994694709778,
0.6314683556556702,
0.07805005460977554,
0.01826055534183979,
0.7228599190711975,
-0.17166107892990112,
0.09680569171905518,
-0.02651747688651085,
0.3800112009048462,
0.005414656829088926,
-0.27775484323501587,
-0.3200223743915558,
-0.5080534815788269,
-0.2075829803943634,
-0.3583580255508423,
0.2830114960670471,
-0.5827750563621521,
0.12257585674524307,
0.436928391456604,
0.3532000184059143,
0.564717710018158,
0.048827674239873886,
-0.07594364136457443,
-0.12622830271720886,
0.053892455995082855,
0.07402795553207397,
-0.5602610111236572,
0.11546620726585388,
0.21992602944374084,
0.2670930027961731,
0.18983040750026703,
-0.04674329236149788,
-1.2200636863708496,
0.3175443112850189,
-0.17276346683502197,
-0.8183501362800598,
-0.5250676274299622,
-0.19748036563396454,
0.3238544166088104,
0.5963900089263916,
0.11509183794260025,
-0.107943594455719,
0.35183751583099365,
0.2924298644065857,
-0.15422554314136505,
0.19241882860660553,
0.8530176877975464,
0.5063220262527466,
0.34927883744239807,
0.2658578157424927,
-0.23652294278144836,
0.05941621586680412,
0.42366692423820496,
0.050829172134399414,
-0.19484123587608337,
-0.711532711982727,
0.17822271585464478,
0.7535077333450317,
0.14014923572540283,
0.10093405097723007,
-0.3228948712348938,
0.20055116713047028,
-0.19007807970046997,
0.28901323676109314,
0.10063039511442184,
-0.03848069906234741,
-0.1955675482749939,
-0.8078544735908508,
0.04586132615804672,
-0.11808034032583237,
-0.24477964639663696,
-0.40330132842063904,
0.8196008801460266,
-0.13639597594738007,
-0.9123497605323792,
0.4288228750228882,
-0.7800590991973877,
0.031614482402801514,
0.29552367329597473,
0.5088914632797241,
0.5439472794532776,
-0.18054720759391785,
-0.21971161663532257,
-0.05083504319190979,
0.6170822978019714,
-0.712860107421875,
-0.5503864288330078,
-0.9498862028121948,
-0.5838750004768372,
-0.03559653460979462,
-0.6456656455993652,
0.021811138838529587,
-1.0994744300842285,
0.11977823823690414,
-0.3225787580013275,
0.3308296799659729,
-0.7427442669868469,
-0.19227683544158936,
0.3549487292766571,
0.19111023843288422,
-0.39548635482788086,
-0.023019053041934967,
-0.0343155562877655,
-0.17994794249534607,
-0.1811835765838623,
-0.1845594048500061,
-0.005594165064394474,
0.1260816603899002,
-0.17074158787727356,
0.2197311520576477,
-0.20783691108226776,
0.035901594907045364,
-0.366798460483551,
0.30805057287216187,
-0.12659867107868195,
0.17417366802692413,
-0.03723131865262985,
-0.23911958932876587,
-0.2008027583360672,
0.026582183316349983,
-0.21551357209682465,
-0.5486097931861877,
-0.21325384080410004,
0.052347972989082336,
-0.03783343732357025,
0.07125475257635117,
-0.13377344608306885,
0.008458757773041725,
0.27349352836608887,
-0.34788942337036133,
0.39084601402282715,
-0.6821686029434204,
-0.6143672466278076,
0.24633195996284485,
-0.7538977265357971,
0.05913751944899559,
0.25489965081214905,
0.35555312037467957,
-0.1638355553150177,
0.3167976140975952,
0.3675808012485504,
0.3050578832626343,
0.007362578995525837,
-0.15388232469558716,
-0.3047502338886261,
-0.0821155235171318,
0.35859501361846924,
0.6810493469238281,
0.2259669452905655,
-0.08428235352039337,
0.7316536903381348,
-0.22368060052394867,
-0.6080368161201477,
0.48941099643707275,
-0.19647999107837677,
0.2771236002445221,
-0.5139791965484619,
-0.662840723991394,
0.27492234110832214,
-0.1847514808177948,
-0.250088095664978,
0.48996007442474365,
0.2121702879667282,
0.3231496810913086,
0.4580309987068176,
-0.3447554409503937,
-0.23925529420375824,
0.034911416471004486,
-0.20812639594078064,
0.06909839808940887,
0.10304594039916992,
-0.3709271252155304,
0.7266157865524292,
-0.01675555296242237,
0.24747776985168457,
-0.05028047785162926,
-0.44722867012023926,
0.11035291850566864,
0.42860254645347595,
0.007925187237560749,
0.03177899494767189,
-0.14207139611244202,
0.025058120489120483,
-0.006179651711136103,
-0.5869449973106384,
-0.5620450377464294,
-0.08105451613664627,
-0.01896088942885399,
0.08508529514074326,
-0.06164143607020378,
-0.6453149318695068,
0.2898566424846649,
-0.19194786250591278,
-0.8347829580307007,
-0.17305921018123627,
0.16413678228855133,
-0.01736634038388729,
0.29173094034194946,
-0.31920695304870605,
0.2484014332294464,
0.03193426504731178,
-0.05750153586268425,
-0.5523152947425842,
-0.37817129492759705,
-0.031182529404759407,
0.010498217307031155,
0.6141337156295776,
0.005562508013099432,
0.5754885673522949,
0.09742695093154907,
0.24905730783939362,
0.595888614654541,
0.3569446802139282,
-0.04178495332598686,
0.2616642415523529,
-0.33417198061943054,
-0.44338324666023254,
-0.18796509504318237,
-0.07724089920520782,
0.09030621498823166,
-0.18053226172924042,
-0.038269173353910446,
0.2791324555873871,
-0.3814674913883209,
0.440965473651886,
-0.4539218246936798,
-0.437311589717865,
0.27674201130867004,
-0.39244967699050903,
0.32035577297210693,
-0.34466156363487244,
0.2573222815990448,
0.030993448570370674,
0.2983739972114563,
-0.009839211590588093,
-0.38673514127731323,
0.11693607270717621,
-0.066309355199337,
-0.4121782183647156,
-0.1592489331960678,
0.7279937863349915,
-0.3668922781944275,
-0.6626343131065369,
-0.6304081082344055,
0.43349120020866394,
0.1777256727218628,
-0.11462395638227463,
0.4747953712940216,
0.04924236983060837,
-0.6568655371665955,
0.10712870955467224,
-0.2694474160671234,
-1.0508304834365845,
-1.1156034469604492,
0.39187684655189514,
-0.21080021560192108,
0.3013175129890442,
-0.02215932123363018,
-0.2811366319656372,
-0.37139707803726196,
-0.48152124881744385,
0.3146005868911743,
-0.023905877023935318,
0.2040567845106125,
-0.2825774848461151,
-0.6946139335632324,
0.10420634597539902,
0.7348901629447937,
-0.4308755397796631,
-0.3500937521457672,
-0.7078908085823059,
0.032581526786088943,
-0.06528077274560928,
-0.14389154314994812,
0.4443519115447998,
-0.3639358878135681,
-0.5161067247390747,
0.380062073469162,
0.3595781922340393,
0.2841747999191284,
-0.1788645088672638,
-0.1404784470796585,
-0.35559791326522827,
0.7628968358039856,
0.7743830680847168,
-0.26581716537475586,
0.2301884889602661,
0.248964324593544,
0.04240370914340019,
0.33601459860801697,
0.686220645904541,
-0.11663446575403214,
0.05191066861152649,
0.05023445561528206,
-5.926717758178711,
0.15985824167728424,
0.41227540373802185,
0.03696600720286369,
-0.06717564165592194,
-0.685660183429718,
-0.4523402154445648,
-0.00650072330608964,
0.6943573951721191,
-0.029640253633260727,
-0.2096613347530365,
-0.25302255153656006,
-0.2442178875207901,
0.3812408447265625,
0.215958833694458,
0.19777575135231018,
0.4026188850402832,
-0.5023983120918274,
0.30367109179496765,
0.43691158294677734,
0.02853456512093544,
0.1861387938261032,
-0.08519032597541809,
0.40896081924438477,
-0.1732265204191208,
0.446936696767807,
-0.3138706386089325,
0.4826297461986542,
-0.7074016332626343,
-0.14766176044940948,
-0.5846761465072632,
-0.09030564874410629,
-0.591183602809906,
-0.501499593257904,
-0.005868382286280394,
0.3856718838214874,
-0.028344735503196716,
-0.19734036922454834,
0.5262187719345093,
0.26671701669692993,
-0.3591674566268921,
0.4326573610305786,
-0.2670843005180359,
0.5088358521461487,
0.3468944728374481,
0.278751939535141,
0.9903849363327026,
0.050294771790504456,
-0.24699676036834717,
0.21231505274772644,
0.2671973407268524,
0.200454980134964,
0.8399147987365723,
-0.1555546373128891,
0.14770430326461792,
0.22617369890213013,
-0.34804847836494446,
-0.7687944769859314,
0.28784874081611633,
-0.1287899911403656,
-0.20163242518901825,
-0.1705934703350067,
0.31160253286361694,
0.3891797363758087,
-0.6762845516204834,
-0.03927423804998398,
-0.24367013573646545,
0.7660377025604248,
0.6083751916885376,
-0.11142442375421524,
0.4186219871044159,
0.13385175168514252,
-0.10049636662006378,
-0.7557066679000854,
-0.07680846005678177,
-0.09487045556306839,
-0.030416471883654594,
-0.056824762374162674,
-0.49155884981155396,
-0.19291633367538452,
-0.1154153123497963,
-0.0441974475979805,
0.0636155754327774,
0.12494843453168869,
0.5879583358764648,
-0.5662126541137695,
0.04872671514749527,
0.01690656691789627,
-0.14738738536834717,
0.15299998223781586,
-0.4060676395893097,
-1.2508771419525146,
0.4381316006183624,
-0.48191437125205994,
0.8022720813751221,
0.5865172743797302,
-0.029726622626185417,
0.0035025940742343664,
0.30741146206855774,
-0.19067350029945374,
0.10247617214918137,
0.15762104094028473,
-0.29479309916496277,
0.2469588965177536,
-0.14295031130313873,
0.6153372526168823,
-0.2612922787666321,
0.410405695438385,
0.3434380888938904,
-0.9637153744697571,
0.37005409598350525,
0.8671360015869141,
-0.07724590599536896,
0.5419739484786987,
-0.22870415449142456,
-0.195687398314476,
-0.13765989243984222,
-0.11901091784238815,
-0.3170420229434967,
-0.813113808631897,
-0.09001196175813675,
0.2522040605545044,
-0.1321377009153366,
-0.44381189346313477,
-0.1272321492433548,
0.337159663438797,
-0.034877993166446686,
-0.18754339218139648,
0.10602138191461563,
0.9518159627914429,
0.4172194004058838,
0.08056331425905228,
0.23670290410518646,
-0.26023632287979126,
0.598850429058075,
0.0900973454117775,
0.13066397607326508,
-0.677077054977417,
-0.3661991357803345,
0.04574254900217056,
0.3012562394142151,
0.02984621934592724,
-0.04079459235072136,
-0.1463468372821808,
0.3255300521850586,
-0.3803701400756836,
0.16178934276103973,
-0.2730391025543213,
-0.1169378012418747,
-0.32213449478149414,
-0.026793222874403,
-0.11395637691020966,
0.5738397836685181,
-0.14538982510566711,
-0.12061220407485962,
-0.4149736762046814,
-0.04234865680336952,
-0.3475729525089264,
-0.343759149312973,
-0.43574774265289307,
0.4395364224910736,
-0.5820834040641785,
-0.03472289443016052,
0.03676805645227432,
0.13348166644573212,
-0.3336793780326843,
-0.10264715552330017,
0.0874810665845871,
0.27708879113197327,
-0.2545282542705536,
-0.018138179555535316,
-0.6050015687942505,
0.09920167922973633,
0.16164147853851318,
0.14675846695899963,
0.012121990323066711,
-0.3198172152042389,
0.01902514323592186,
-0.26108139753341675,
0.07013783603906631,
-0.22209352254867554,
-0.2217928171157837,
-0.3744063675403595,
0.4201135039329529,
-0.04484299197793007,
0.3405519723892212,
-0.7450613975524902,
0.024716639891266823,
0.45330923795700073,
0.6937953233718872,
0.0752611756324768,
-0.832017183303833,
-0.045036546885967255,
0.5537779331207275,
-0.18164633214473724,
-0.35486695170402527,
0.25607869029045105,
-0.2295973151922226,
-0.02589963562786579,
-0.12025386095046997,
0.1403854638338089,
-0.2387540489435196,
-0.2451774626970291,
0.13782870769500732,
-0.5679054260253906,
-0.41225868463516235,
0.4581570625305176,
-0.20775218307971954,
-0.23662292957305908,
0.04961321875452995,
-0.18901465833187103,
-0.6870233416557312,
-0.5773178935050964,
0.18307825922966003,
-0.2945728302001953,
-0.38617920875549316,
-0.22496278584003448,
0.015849879011511803,
-0.268669992685318,
-0.2749374806880951,
0.03696984052658081,
-0.8148856163024902,
-0.38810479640960693,
-0.025172395631670952,
-0.1502196341753006,
0.04896705970168114,
0.22394172847270966,
-0.05397177115082741,
0.2469419240951538,
-0.03264225274324417,
-0.42337819933891296,
1.041951298713684,
-0.23077920079231262,
0.5565585494041443,
-0.31003889441490173,
0.608592689037323,
-0.7702485918998718,
0.08621510863304138,
-0.6096031665802002,
-0.02853826992213726,
0.29969823360443115,
0.2085707187652588,
-0.4000083804130554,
0.6077346205711365,
-0.518153965473175,
0.34654539823532104,
0.28409817814826965,
-0.6033403873443604,
-0.05450035631656647,
0.4529287815093994,
-0.6848151683807373,
0.0723842903971672,
0.20467908680438995,
-0.10367891937494278,
0.44089752435684204,
-0.36706554889678955,
0.18545079231262207,
-0.10165735334157944,
0.12503987550735474,
-0.046692509204149246,
-0.07009854167699814,
0.18909285962581635,
0.35962802171707153,
0.08282849192619324,
0.04460080713033676,
0.0568276047706604,
0.6421523094177246,
0.2641369700431824,
0.06410586833953857,
0.27596914768218994,
0.29972729086875916,
-0.7036498188972473,
-0.16414666175842285,
0.033663712441921234,
0.07351209223270416,
0.20434892177581787,
-0.46359142661094666,
-0.5439566373825073,
-0.9238333106040955,
0.7518335580825806,
-0.23520536720752716,
0.1129995658993721,
-0.23092907667160034,
0.11087613552808762,
-0.09935221821069717,
-0.9354085326194763,
0.16645683348178864,
0.17975454032421112,
-0.5378636717796326,
-0.5492104291915894,
0.41337937116622925,
0.5800880789756775,
0.10638631135225296,
-0.33817175030708313,
0.5746670961380005,
-0.022355975583195686,
-0.2026936411857605,
0.31927573680877686,
0.40780094265937805,
-0.05101113021373749,
-0.13658465445041656,
-0.8546320796012878,
-0.2016657441854477,
0.03351324796676636,
-0.1771748811006546,
-0.37395960092544556,
-0.03345078229904175,
-0.6526021361351013,
0.12836319208145142,
0.1983776092529297,
0.6344493627548218,
-0.4830472469329834,
0.00027233120636083186,
0.5377674102783203,
0.24042531847953796,
-0.018643002957105637,
0.20486709475517273,
-0.12828630208969116,
0.4258779287338257,
0.036379870027303696,
-0.12309711426496506,
0.968438446521759,
0.34873682260513306,
-0.10962457954883575,
-0.2355499267578125,
0.5139114856719971,
0.04202704504132271,
0.39189770817756653,
-0.1655423492193222,
0.05406373739242554,
0.7246348261833191,
0.09051239490509033,
0.22606003284454346,
0.4750409722328186,
-0.2502919137477875,
-0.41616392135620117,
0.3024485409259796,
-0.09973996132612228,
0.31970423460006714,
0.7033059597015381,
-0.14586137235164642,
-0.6549742221832275,
0.41837021708488464,
0.5309693217277527,
-0.09886568039655685,
0.3642052412033081,
0.17431573569774628,
0.18348105251789093,
-0.7551875710487366,
0.7793015241622925,
0.3865963816642761,
0.42172300815582275,
0.010295970365405083,
0.6963356733322144,
-0.21687792241573334,
-0.13037286698818207,
0.6820765137672424,
-0.027327176183462143,
-0.17987865209579468,
-0.07623502612113953,
0.5820028185844421,
0.35144758224487305,
0.09853458404541016,
-0.41020703315734863,
-1.1194757223129272,
0.6177181005477905,
0.2997124493122101,
-0.031544096767902374,
-0.06057187542319298,
-0.3863482177257538,
-0.5932437181472778,
-0.016541818156838417,
-0.17606118321418762,
0.8261231780052185,
0.457338809967041,
0.6508395075798035,
-0.0012006243923678994,
0.5394740104675293,
0.15253518521785736,
0.1912892609834671,
-0.43653446435928345,
0.17960892617702484,
-0.6596009135246277,
-0.2381877303123474,
0.01935752108693123,
-0.3261159658432007,
-0.1887521892786026,
0.29278498888015747,
0.3507181704044342,
0.19733290374279022,
-0.1805429607629776,
0.6191128492355347,
0.22348980605602264,
0.17281083762645721,
-0.2651877999305725,
-0.0181918703019619,
0.0824960470199585,
0.4466002881526947,
-0.030238976702094078,
0.28071486949920654,
0.23278141021728516,
0.2960681915283203,
0.18854571878910065,
0.32386285066604614,
-0.22935795783996582,
0.16373533010482788,
-0.31030547618865967,
0.3944079577922821,
-0.10205652564764023,
-0.27200567722320557,
0.2351718693971634,
0.1578563153743744,
-0.4197356700897217,
0.30079665780067444,
0.5369536876678467,
-0.018321508541703224,
-0.19461378455162048,
-0.057749275118112564,
0.5191723704338074,
-0.5366772413253784,
-0.2823029160499573,
-0.30010727047920227,
0.48116350173950195,
0.5730797052383423,
0.4100930392742157,
0.7864708304405212,
-0.25818997621536255,
0.06303063780069351,
-0.14138896763324738,
0.10440759360790253,
-0.022119775414466858,
-0.05415227636694908,
-0.4690716862678528,
-0.0709342360496521,
-0.22036102414131165,
-0.42220842838287354,
0.48474106192588806,
-0.46471768617630005,
0.4343828856945038,
-0.17350706458091736,
-0.04658008739352226,
0.04700089618563652,
0.530000627040863,
-0.028570136055350304,
0.434516042470932,
-0.6207054853439331,
0.6326807737350464,
0.35986989736557007,
-0.19263778626918793,
0.8151133060455322,
-0.0821625366806984,
-0.09531925618648529,
0.04366768151521683,
-0.11371362954378128,
0.5795555710792542,
-0.13917334377765656,
-0.04046087712049484,
-0.2095411717891693,
0.17678895592689514,
0.14281535148620605
] |
|
Cellular uptake of therapeutic oligonucleotides and subsequent intracellular trafficking to their target sites represents the major technical hurdle for the biological effectiveness of these potential drugs. Accordingly, laboratories worldwide focus on the development of suitable delivery systems. Among the different available non-viral systems like cationic polymers, cationic liposomes and polymeric nanoparticles, cell-penetrating peptides (CPPs) represent an attractive concept to bypass the problem of poor membrane permeability of these charged macromolecules. While uptake per se in most cases does not represent the main obstacle of nucleic acid delivery in vitro, it becomes increasingly apparent that intracellular trafficking is the bottleneck. As a consequence, in order to optimize a given delivery system, a side-by-side analysis of nucleic acid cargo internalized and the corresponding biological effect is required to determine the overall efficacy. In this review, we will concentrate on peptide-mediated delivery of siRNAs and steric block oligonucleotides and discuss different methods for quantitative assessment of the amount of cargo taken up and how to correlate those numbers with biological effects by applying easy to handle reporter systems. To illustrate current limitations of non-viral nucleic acid delivery systems, we present own data as an example and discuss options of how to enhance trafficking of molecules entrapped in cellular compartments. | [
-0.007737661711871624,
0.010372433811426163,
-0.004632761236280203,
0.021942541003227234,
0.001390611520037055,
-0.018991053104400635,
0.01176599320024252,
-0.004208561964333057,
-0.011499687097966671,
-0.02274203673005104,
-0.007465059868991375,
0.002867870032787323,
0.013592272996902466,
0.012068473733961582,
0.00010800827294588089,
-0.013315869495272636,
0.014512654393911362,
0.03046257421374321,
0.007075626868754625,
-0.01277727447450161,
-0.015242896042764187,
-0.001452484168112278,
0.010014550760388374,
-0.02909945696592331,
-0.0010774480178952217,
0.006596339866518974,
0.04974500089883804,
-0.025808529928326607,
-0.026267852634191513,
-0.009750543162226677,
0.005974099040031433,
-0.023569293320178986,
0.018382182344794273,
-0.014886698685586452,
0.0062340423464775085,
0.00749437278136611,
-0.001347583020105958,
0.020650222897529602,
0.03375498205423355,
-0.005796696059405804,
-0.013749152421951294,
-0.011106761172413826,
-0.0036939075216650963,
-0.003186167450621724,
-0.007646284066140652,
0.005958313122391701,
0.0010682891588658094,
0.007714725099503994,
-0.015744492411613464,
0.008353615179657936,
-0.0005001685349270701,
0.0037123970687389374,
-0.008576750755310059,
0.007808445952832699,
-0.007389134727418423,
-0.019184380769729614,
0.01909119263291359,
0.004450819920748472,
-0.02500974014401436,
-0.016218598932027817,
0.01421924214810133,
0.007999679073691368,
-0.013737143017351627,
0.007542870938777924,
-0.004488053731620312,
-0.06667029857635498,
-0.008499626070261002,
0.003447378985583782,
0.002568654716014862,
0.029187966138124466,
-0.017020627856254578,
0.011707251891493797,
-0.0027615148574113846,
-0.02914305031299591,
-0.0008030738681554794,
-0.011500382795929909,
0.022077526897192,
0.01763380505144596,
0.029449451714754105,
0.006392480805516243,
-0.004605982918292284,
-0.014019029214978218,
-0.02216220088303089,
0.016564082354307175,
-0.003053120570257306,
0.015396250411868095,
-0.02117374911904335,
0.01789318397641182,
0.007447042502462864,
-0.007333412766456604,
0.00512444693595171,
-0.004885005299001932,
-0.02961430512368679,
0.007244759239256382,
-0.005149492062628269,
-0.007160446140915155,
-0.020720044150948524,
0.013492193073034286,
0.02017158269882202,
-0.021420283243060112,
-0.011466430500149727,
-0.016064293682575226,
0.0165666826069355,
0.0034109922125935555,
0.03808256983757019,
0.0149314533919096,
0.010258141905069351,
0.01972472295165062,
0.021867938339710236,
0.010976424440741539,
0.002522774040699005,
0.03721844032406807,
-0.010464154183864594,
-0.015419650822877884,
0.001044736709445715,
-0.0066317119635641575,
0.0029759295284748077,
-0.016439512372016907,
0.01829831302165985,
0.012870563194155693,
0.034075308591127396,
-0.010529777966439724,
0.0017954218201339245,
0.04347853362560272,
0.007630906533449888,
-0.013810720294713974,
-0.015710871666669846,
0.00346016907133162,
0.0023772004060447216,
-0.00294336024671793,
-0.012113522738218307,
0.008068904280662537,
0.014537418261170387,
0.022495727986097336,
0.012152444571256638,
0.00749566126614809,
0.02427225559949875,
-0.015582384541630745,
0.010498086921870708,
-0.013320822268724442,
-0.010209379717707634,
0.0026393106672912836,
0.003307394217699766,
0.003334703389555216,
0.025483358651399612,
0.00815656315535307,
-0.01805933006107807,
0.00014110561460256577,
0.012294194661080837,
-0.005814960692077875,
0.009469091892242432,
0.004745871759951115,
-0.016941973939538002,
-0.024461787194013596,
0.005402703303843737,
-0.0192476287484169,
-0.0009192917495965958,
0.008493321016430855,
-0.013632499612867832,
-0.017204366624355316,
0.0034118271432816982,
0.0015323555562645197,
0.04023030027747154,
0.011851940304040909,
0.017807945609092712,
0.010219626128673553,
-0.01023141760379076,
-0.005037646275013685,
0.009778936393558979,
0.010113752447068691,
-0.02068738453090191,
0.013707238249480724,
0.00458342581987381,
0.012524222955107689,
0.02808571606874466,
0.0014523995341733098,
0.0026343734934926033,
0.010987520217895508,
-0.02277478389441967,
0.06642879545688629,
0.004580030217766762,
0.03377401828765869,
0.017039645463228226,
-0.030163193121552467,
0.00618867389857769,
-0.03681384399533272,
0.013441942632198334,
0.001989617943763733,
-0.013251466676592827,
-0.01469189953058958,
-0.010450128465890884,
-0.0337325818836689,
0.0034296303056180477,
0.008654838427901268,
-0.01599736325442791,
0.002959433477371931,
-0.01732136681675911,
0.015323501080274582,
-0.003156073857098818,
-0.01377292163670063,
0.025777408853173256,
-0.016560664400458336,
-0.01224660687148571,
0.02181163616478443,
-0.018665311858057976,
0.009179117158055305,
-0.009483802132308483,
-0.00044226786121726036,
-0.019452938809990883,
0.012597298249602318,
0.019237369298934937,
0.006755715236067772,
0.02109912410378456,
-0.011151776649057865,
0.008897332474589348,
-0.0005893274792470038,
-0.031709007918834686,
-0.0018062416929751635,
-0.010612455196678638,
-0.011837567202746868,
-0.007133015431463718,
0.007515410427004099,
0.024905981495976448,
0.024337492883205414,
0.01034050527960062,
-0.02090124599635601,
-0.009151870384812355,
0.011559597216546535,
0.008974864147603512,
-0.009018514305353165,
-0.014294803142547607,
-0.014193704351782799,
-0.017837826162576675,
-0.013152414932847023,
0.002561426255851984,
-0.00913194939494133,
0.013699058443307877,
0.009036248549818993,
0.011920249089598656,
-0.016530312597751617,
-0.020989548414945602,
0.01492175180464983,
0.03700559213757515,
-0.01640305295586586,
0.013132350519299507,
-0.005654173903167248,
-0.01658954843878746,
0.0251699797809124,
0.015022112987935543,
-0.003259354969486594,
0.007800635881721973,
0.0015641020145267248,
0.019237158820033073,
-0.009494870901107788,
-0.021363168954849243,
-0.008838595822453499,
-0.006990177556872368,
-0.026095645502209663,
0.026016008108854294,
0.027582470327615738,
0.0036563370376825333,
0.00950013566762209,
-0.016437754034996033,
-0.008151146583259106,
0.0033360086381435394,
-0.026874184608459473,
0.022887662053108215,
-0.016609445214271545,
0.0071391877718269825,
0.03631460666656494,
0.008725662715733051,
-0.003431793302297592,
-0.0012915318366140127,
-0.08108694851398468,
-0.021581146866083145,
-0.00485406257212162,
0.010701189748942852,
0.0052689374424517155,
0.0006572804413735867,
0.015236036852002144,
-0.0014735645381733775,
-0.0034425503108650446,
0.012204607017338276,
-0.021130727604031563,
0.02792031690478325,
-0.011612135916948318,
0.011936265043914318,
-0.008525899611413479,
-0.01584986224770546,
0.01078294962644577,
-0.010005026124417782,
-0.007375561632215977,
0.00006855325773358345,
-0.0063374959863722324,
0.008045639842748642,
-0.004001055844128132,
-0.0048900474794209,
-0.023802317678928375,
0.0433974415063858,
0.015940027311444283,
0.003590640611946583,
0.0003248765133321285,
0.00591075886040926,
-0.0010152969043701887,
0.010981420055031776,
0.01673104241490364,
0.008802508935332298,
-0.014185883104801178,
-0.006238660309463739,
-0.0010142105165868998,
-0.0009702038951218128,
-0.005928855389356613,
0.02352006733417511,
-0.021581795066595078,
0.016139894723892212,
-0.019674202427268028,
0.00926981121301651,
-0.00964498519897461,
-0.017871467396616936,
-0.006183854304254055,
0.030961662530899048,
0.018068499863147736,
0.015528840944170952,
0.009741267189383507,
-0.005982538219541311,
0.024860354140400887,
0.023690491914749146,
-0.005475603509694338,
-0.008133616298437119,
-0.01020660251379013,
0.014187009073793888,
-0.01946614868938923,
-0.003890170017257333,
0.0039792368188500404,
-0.0019647402223199606,
0.008825503289699554,
0.0024276217445731163,
-0.003771706949919462,
0.026677697896957397,
0.01796288974583149,
0.01441517286002636,
-0.011814577504992485,
0.010992329567670822,
-0.003740824293345213,
-0.02285045012831688,
-0.00001601269468665123,
-0.01174748595803976,
-0.005578146781772375,
-0.01820744387805462,
-0.016124702990055084,
0.007575063966214657,
0.021610965952277184,
-0.018490226939320564,
-0.025008607655763626,
-0.000012907199561595917,
-0.015149439685046673,
-0.00555478734895587,
0.0013706416357308626,
0.030162984505295753,
0.0070755984634160995,
-0.005114204715937376,
0.005575177259743214,
-0.01309946645051241,
-0.010914679616689682,
0.0004626750014722347,
0.007593065965920687,
0.009398957714438438,
-0.013441432267427444,
-0.018002651631832123,
0.009704814292490482,
-0.0009618134936317801,
0.015020527876913548,
0.010740065015852451,
-0.012141049839556217,
0.002617564983665943,
-0.014002609066665173,
-0.011039070785045624,
-0.030097778886556625,
0.01696815714240074,
-0.008073896169662476,
-0.0018719339277595282,
0.00047578802332282066,
0.00003971450496464968,
-0.040174733847379684,
-0.011193452402949333,
-0.004796518012881279,
0.005947541445493698,
0.007655984256416559,
0.03291160240769386,
0.002659587189555168,
0.01682298257946968,
0.0718143880367279,
0.0009937718277797103,
-0.004545916337519884,
-0.011734414845705032,
-0.018135175108909607,
-0.01961638033390045,
-0.024130411446094513,
0.016738146543502808,
0.005948436446487904,
0.00606183335185051,
0.013469025492668152,
0.007642699871212244,
0.012805784121155739,
0.009170252829790115,
-0.01775953359901905,
-0.005890036933124065,
-0.040336623787879944,
-0.018442416563630104,
0.015728209167718887,
0.00850799959152937,
0.007772472221404314,
-0.03323282301425934,
0.03485211730003357,
-0.0138663649559021,
0.005018486175686121,
-0.013669027015566826,
-0.011378898285329342,
-0.009746812283992767,
-0.03868842497467995,
0.016090890392661095,
0.015713311731815338,
0.0035112916957587004,
-0.010334759950637817,
-0.021223686635494232,
0.024490438401699066,
0.009006282314658165,
0.010609623044729233,
0.0001491133589297533,
-0.011549897491931915,
-0.00568702258169651,
-0.012190318666398525,
-0.01109560951590538,
0.016349349170923233,
0.004055827856063843,
-0.01150908600538969,
-0.020195823162794113,
-0.011825130321085453,
-0.010613374412059784,
0.011744581162929535,
-0.02563808113336563,
-0.010934293270111084,
0.00023532295017503202,
0.018857154995203018,
0.03512778878211975,
-0.021379198879003525,
0.027190109714865685,
0.004699789918959141,
-0.004357535392045975,
-0.02489040046930313,
0.021352512761950493,
0.003316044807434082,
0.012748610228300095,
0.0092875761911273,
-0.030708597972989082,
-0.0006711529567837715,
-0.006213349290192127,
0.015281649306416512,
0.007409037556499243,
-0.003680948633700609,
-0.0036888986360281706,
-0.0255231112241745,
0.014923978596925735,
0.026326321065425873,
0.01090926956385374,
-0.011456738226115704,
0.0038690005894750357,
0.012277328409254551,
0.00979783944785595,
0.019682087004184723,
0.012677877210080624,
0.027281345799565315,
0.022757921367883682,
0.0009115170687437057,
-0.0661822110414505,
-0.024873286485671997,
-0.026150468736886978,
-0.02791759744286537,
-0.07450013607740402,
-0.03668421134352684,
-0.022798195481300354,
-0.002774678636342287,
-0.007231513503938913,
0.007960133254528046,
-0.009059533476829529,
0.0010625282302498817,
-0.0068673198111355305,
-0.001101638306863606,
0.017786074429750443,
0.01582554168999195,
0.0031945134978741407,
-0.013341325335204601,
0.012397902086377144,
-0.005279109813272953,
-0.02958417311310768,
0.007164318114519119,
-0.005341274663805962,
-0.008646262809634209,
0.016033951193094254,
0.0037782711442559958,
-0.05411696806550026,
-0.01217064168304205,
-0.007410154212266207,
-0.08077023923397064,
-0.018319055438041687,
0.013216111809015274,
0.01711781695485115,
-0.012281756848096848,
-0.006335719022899866,
0.007040139753371477,
-0.003103511407971382,
-0.03054303675889969,
-0.016056284308433533,
-0.004232177976518869,
0.025743717327713966,
-0.005789760500192642,
0.0015663404483348131,
-0.01806763932108879,
-0.0075307972729206085,
0.020872129127383232,
0.0063970061019063,
-0.02036290057003498,
-0.009336361661553383,
0.004593676887452602,
0.0231359601020813,
-0.01072134729474783,
-0.007189313415437937,
-0.0046018147841095924,
-0.014094733633100986,
-0.0030173708219081163,
0.01359582133591175,
0.01920429803431034,
-0.029190942645072937,
-0.016789745539426804,
-0.0104429442435503,
-0.007691524922847748,
-0.00692607369273901,
-0.00309782475233078,
-0.02195487730205059,
0.01029213797301054,
0.009408065117895603,
0.019448477774858475,
-0.001028027618303895,
-0.006579444743692875,
0.008355007506906986,
-0.018554290756583214,
-0.0012478092685341835,
0.008327189832925797,
-0.02314252406358719,
0.005513118114322424,
-0.013002041727304459,
0.01480516791343689,
-0.023553218692541122,
0.009744349867105484,
0.017981180921196938,
-0.01914372853934765,
0.0040157451294362545,
-0.0167028047144413,
0.015551414340734482,
-0.0055794864892959595,
0.02026265673339367,
0.0032621813006699085,
0.021284732967615128,
0.007627951912581921,
0.021459436044096947,
-0.016199197620153427,
0.07093776762485504,
-0.048341862857341766,
0.02017013169825077,
-0.016992587596178055,
-0.01641296222805977,
0.0087728351354599,
0.012030195444822311,
-0.050458867102861404,
-0.017475441098213196,
-0.01746673323214054,
0.017078036442399025,
-0.011621244251728058,
0.0045592086389660835,
0.015351880341768265,
0.023188771679997444,
-0.0017171910731121898,
-0.01646815612912178,
0.0034759901463985443,
0.02929956465959549,
0.02642345428466797,
-0.004145106766372919,
0.012929992750287056,
-0.019944991916418076,
-0.0031030536629259586,
-0.0034224933478981256,
-0.0002272489946335554,
0.0035578864626586437,
-0.0006308527663350105,
-0.007073641754686832,
-0.006362098269164562,
-0.014380626380443573,
0.00398567970842123,
0.004104831255972385,
-0.002856799867004156,
0.02700170874595642,
0.009516979567706585,
0.006059860344976187,
0.0036942099686712027,
-0.010373941622674465,
0.00011507375165820122,
-0.030077632516622543,
0.0015858553815633059,
-0.005721650086343288,
-0.025800835341215134,
0.012791800312697887,
-0.00902468990534544,
0.012473446317017078,
0.025865327566862106,
0.00858315359801054,
0.004802132956683636,
0.0008805813267827034,
0.0008892684709280729,
0.013606596738100052,
0.015216808766126633,
-0.0036073573864996433,
-0.0058484505861997604,
-0.009479943662881851,
0.013251258060336113,
0.0008761782664805651,
-0.014696013182401657,
0.018544847145676613,
-0.009231816977262497,
0.0223684161901474,
-0.004455022979527712,
0.011533909477293491,
-0.011298129335045815,
-0.000980054959654808,
-0.014347190037369728,
-0.006195224821567535,
0.015298484824597836,
-0.0027577111031860113,
0.018938960507512093,
0.011482964269816875,
-0.01578284427523613,
0.03419177234172821,
0.0034135188907384872,
-0.003782344749197364,
0.006864642724394798,
0.02764790691435337,
0.014628560282289982,
-0.011703500524163246,
0.020632930099964142,
0.0019858269952237606,
0.007748512085527182,
-0.01152404397726059,
0.008109940215945244,
0.030446672812104225,
0.02313994988799095,
-0.0011937377275899053,
0.01298213005065918,
0.021956056356430054,
-0.013642555102705956,
-0.0023797794710844755,
0.022061724215745926,
0.012279724702239037,
0.03486952185630798,
0.02852955460548401,
0.006607050076127052,
-0.03781639039516449,
0.013032061979174614,
-0.001139017753303051,
-0.0030092885717749596,
-0.031207170337438583,
0.004363293293863535,
0.0020740628242492676,
0.01462673582136631,
-0.013784272596240044,
-0.020389476791024208,
-0.007470608223229647,
0.01417667604982853,
-0.001857528812251985,
-0.011721601709723473,
-0.004308163654059172,
-0.015090640634298325,
0.008109359070658684,
0.00982636958360672,
-0.016610894352197647,
0.026030777022242546,
-0.007562474347651005,
-0.019252117723226547,
0.009251263923943043,
-0.00375125790014863,
-0.017971046268939972,
0.0014405119000002742,
-0.022233139723539352,
-0.01110265776515007,
-0.015277695842087269,
-0.006815300323069096,
0.0058867670595645905,
-0.004129290115088224,
0.03113536909222603,
-0.021753504872322083,
-0.005336417350918055,
-0.0017204107716679573,
-0.010906333103775978,
-0.019731825217604637,
-0.011679794639348984,
0.008677400648593903,
-0.013234300538897514,
-0.0006223707459867001,
0.014076489955186844,
-0.020435361191630363,
-0.004112942609935999,
-0.0006076488643884659,
0.010688088834285736,
0.01997251994907856,
-0.015441518276929855,
0.03365957736968994,
0.007109020836651325,
0.014912106096744537,
0.00439363531768322,
0.007627333048731089,
0.01026437059044838,
-0.011977232061326504,
0.010426303371787071,
0.024297066032886505,
0.0025342334993183613,
-0.005362409166991711,
0.010259984992444515,
-0.017630232498049736,
0.011563016101717949,
-0.002913453383371234,
-0.02375069633126259,
0.0028863665647804737,
0.013362692669034004,
-0.009808773174881935,
-0.023255586624145508,
-0.007715075276792049,
0.00036797020584344864,
-0.011009730398654938,
0.03586496412754059,
0.0025991909205913544,
0.0035703859757632017,
-0.003693346632644534,
-0.008519849739968777,
-0.003278908086940646,
-0.01088496670126915,
-0.00842410046607256,
0.018667425960302353,
0.008007568307220936,
0.011152170598506927,
-0.026203427463769913,
0.01738002523779869,
-0.013521742075681686,
0.004578844644129276,
0.006112260743975639,
-0.006761102005839348,
-0.03561783581972122,
0.011078889481723309,
0.0329149067401886,
-0.004138163756579161,
-0.009843366220593452,
-0.020141376182436943,
0.011020101606845856,
-0.02408415824174881,
-0.027661845088005066,
0.015508811920881271,
-0.026684900745749474,
0.005904844030737877,
-0.0036149139050394297,
0.008976245298981667,
-0.010339487344026566
] | [
0.10471194237470627,
-0.09182716906070709,
0.48508337140083313,
0.08455535769462585,
0.35050827264785767,
-0.019670234993100166,
-0.11910814046859741,
-0.3052303194999695,
-0.08490316569805145,
-0.5334022045135498,
-0.08792126178741455,
0.30607324838638306,
-0.58818119764328,
0.12560655176639557,
0.2563922107219696,
0.42723381519317627,
0.7814555764198303,
0.32045361399650574,
-0.12759463489055634,
-0.5925744771957397,
-0.8242948055267334,
0.035121165215969086,
0.7532820701599121,
0.06719319522380829,
0.4670267105102539,
-0.14642253518104553,
-0.06663864105939865,
-0.03792501613497734,
-0.0779644325375557,
-0.3022993803024292,
0.12148363888263702,
-0.08420102298259735,
-0.16213537752628326,
-0.25312161445617676,
0.2157210260629654,
-0.04261764883995056,
-0.536429226398468,
0.3083564043045044,
-0.2510180175304413,
-0.6803480386734009,
-0.5146061778068542,
0.0025708889588713646,
-0.27407369017601013,
0.3117749094963074,
-0.4080383777618408,
-0.37682756781578064,
-1.0456904172897339,
0.3953644633293152,
-0.6830193400382996,
0.19741752743721008,
0.050682779401540756,
0.2209843546152115,
0.21169066429138184,
0.17170119285583496,
0.29905855655670166,
0.18877050280570984,
-0.40042951703071594,
-0.16120341420173645,
0.3421419858932495,
-0.37306684255599976,
-0.19869884848594666,
-0.18917930126190186,
-0.3914373517036438,
0.19595710933208466,
0.2280799150466919,
0.2565714120864868,
0.31429925560951233,
-0.6377407908439636,
-0.6799110174179077,
-0.15334555506706238,
0.16463613510131836,
-0.42766860127449036,
-0.08979286998510361,
0.2667442560195923,
-0.4340605139732361,
-0.3114887475967407,
-0.02080891840159893,
-0.010188058018684387,
0.028240717947483063,
0.08372556418180466,
-0.05237048491835594,
0.3150552809238434,
-0.061425190418958664,
-0.10956810414791107,
0.6181917786598206,
0.33897438645362854,
-0.08836399018764496,
0.7990822792053223,
-0.5629528760910034,
0.17304503917694092,
0.320786714553833,
0.1495954990386963,
0.018374677747488022,
0.16801083087921143,
0.2737198770046234,
-0.07307017594575882,
0.11026492714881897,
-0.42135852575302124,
0.1533949226140976,
0.5723829865455627,
-0.0515284463763237,
-0.03160129487514496,
0.3986765444278717,
-0.3436387777328491,
0.17021876573562622,
-0.3125879764556885,
-0.268902450799942,
-0.3252124488353729,
-0.6951190829277039,
-0.04876554757356644,
-0.22368291020393372,
0.5363012552261353,
-0.20571498572826385,
-0.15547317266464233,
-0.20352578163146973,
0.030186299234628677,
0.03922924026846886,
-0.07291917502880096,
-0.42920830845832825,
0.02160068228840828,
-0.02985100820660591,
1.6647547483444214,
-0.31809818744659424,
0.3492238223552704,
-0.008873498067259789,
-0.24917711317539215,
0.4663102626800537,
0.15982773900032043,
-0.4039383828639984,
0.5395882725715637,
0.016909362748265266,
0.6839984059333801,
-0.10185367614030838,
0.10007333755493164,
-0.20248481631278992,
-0.3270200788974762,
0.3189224898815155,
0.43439701199531555,
0.6341578364372253,
-0.31732797622680664,
-0.5316179394721985,
-0.4280289113521576,
0.16954560577869415,
-0.294824481010437,
0.05608058348298073,
-0.3437311053276062,
-0.09625732898712158,
-0.2928517162799835,
-0.12169667333364487,
-0.08637363463640213,
0.13569660484790802,
0.23123443126678467,
-0.6740506887435913,
-0.01833719201385975,
-0.1366414725780487,
0.3004189431667328,
-0.12185376137495041,
-0.1546926200389862,
-0.20557737350463867,
0.08478610217571259,
-0.05956733226776123,
-0.019146207720041275,
-0.11772853881120682,
0.03352482616901398,
0.16731122136116028,
-0.392286092042923,
0.3447398543357849,
0.5664268136024475,
0.3543270528316498,
-0.18447376787662506,
0.12907321751117706,
-0.25961315631866455,
-0.09182022511959076,
-1.0195351839065552,
0.005141517613083124,
-0.22235336899757385,
0.3019310534000397,
0.1877637654542923,
-0.07279210537672043,
0.03776516392827034,
-0.6711706519126892,
0.6804922819137573,
-0.14470471441745758,
-0.8982945084571838,
-0.0063334871083498,
-0.013004252687096596,
1.107379674911499,
0.2645522654056549,
-0.371878057718277,
0.18074773252010345,
-0.1722194105386734,
-0.050379011780023575,
0.0564613863825798,
-0.9024056196212769,
1.5629010200500488,
-0.1255125105381012,
0.0610995888710022,
1.1154119968414307,
-0.07393842935562134,
-0.2650337219238281,
0.10886707156896591,
0.5608294606208801,
0.5621210336685181,
-0.8864776492118835,
-0.8602956533432007,
-0.3801954686641693,
0.13420327007770538,
-0.23678191006183624,
0.28428274393081665,
0.320848286151886,
0.8148643970489502,
-0.28185194730758667,
0.24018213152885437,
-0.5188578963279724,
0.314710795879364,
-0.6699657440185547,
-0.08752671629190445,
0.482693076133728,
-0.10760744661092758,
0.13382238149642944,
0.5714166760444641,
-0.7752333283424377,
0.6184360384941101,
1.2635741233825684,
-0.01940656639635563,
0.6884243488311768,
0.26836246252059937,
-0.11435241997241974,
0.6250566244125366,
0.06330554932355881,
0.540738046169281,
-0.6960282921791077,
-0.09288670867681503,
-0.255538672208786,
-0.18573643267154694,
0.01355190109461546,
-0.00034083827631548047,
-0.06632550805807114,
-0.3044591546058655,
0.11613024771213531,
-0.29002001881599426,
0.3043963611125946,
-0.8257583975791931,
-0.18912340700626373,
0.13988666236400604,
-0.49842965602874756,
-0.4825529456138611,
-0.10348804295063019,
-0.49323251843452454,
-0.19841817021369934,
-0.06706401705741882,
0.3355497121810913,
0.43044647574424744,
-0.7486207485198975,
0.33356624841690063,
-0.27221015095710754,
-0.0944765955209732,
0.28174859285354614,
0.07716076821088791,
-0.37977755069732666,
-0.1773790717124939,
0.17337839305400848,
0.03895965591073036,
0.13111814856529236,
-0.31760168075561523,
-0.1801832914352417,
-0.49448463320732117,
-0.8522729277610779,
0.7058921456336975,
0.6163085699081421,
0.9520914554595947,
0.24157369136810303,
-0.39961814880371094,
-0.10399702191352844,
-0.2796581983566284,
-0.6193938851356506,
0.7410003542900085,
0.5333359241485596,
-0.4463534653186798,
-0.3594204783439636,
0.08696983009576797,
0.238499253988266,
0.2567799985408783,
-0.4115365445613861,
-0.4858378767967224,
-0.35453683137893677,
-0.10780587792396545,
-0.45314332842826843,
-0.08600331097841263,
0.08423682302236557,
-0.46994227170944214,
-0.04072297737002373,
-0.4109553396701813,
-0.22403906285762787,
0.3759727478027344,
0.08118430525064468,
0.35582107305526733,
0.5511873364448547,
0.4555632472038269,
0.028341442346572876,
-0.2830214202404022,
-0.04705265536904335,
-0.5061690211296082,
0.4744364321231842,
-0.4278298020362854,
-0.5229154825210571,
0.019497523084282875,
0.10134067386388779,
-5.837895393371582,
0.07855203747749329,
-0.08133915066719055,
0.20448069274425507,
0.1375490427017212,
-0.08901460468769073,
0.9988664984703064,
-0.12916776537895203,
0.28457412123680115,
0.09173685312271118,
-0.1882132738828659,
0.52263343334198,
0.1714693009853363,
-0.14115142822265625,
-0.28623154759407043,
0.105104960501194,
0.049338676035404205,
0.11814931780099869,
0.45975276827812195,
0.21193867921829224,
0.48097503185272217,
-0.41595733165740967,
0.4235268235206604,
0.678331732749939,
0.04486139491200447,
0.016985755413770676,
-0.6254094243049622,
0.28189244866371155,
-0.5552720427513123,
-0.40818145871162415,
-0.021518906578421593,
-0.6483563780784607,
0.5976113677024841,
-0.6836475133895874,
0.37058717012405396,
-0.04374374449253082,
0.08784236013889313,
0.1034829169511795,
0.041811130940914154,
-0.7123426795005798,
0.5486800074577332,
0.21325719356536865,
-0.24173825979232788,
-0.06878549605607986,
0.1966354101896286,
-0.003037822898477316,
0.044390808790922165,
0.06453633308410645,
-0.1763363629579544,
1.1012797355651855,
-0.12002716958522797,
0.12917865812778473,
0.8976582884788513,
0.27014297246932983,
0.36272773146629333,
-0.28096455335617065,
-0.29651939868927,
-0.0667162761092186,
-0.04818878322839737,
0.12164799869060516,
-0.2717294991016388,
-0.08454207330942154,
-0.5146534442901611,
-0.7781887054443359,
0.014332705177366734,
0.3707771599292755,
-0.5543438792228699,
-0.7038130164146423,
0.14281462132930756,
0.16115052998065948,
-0.45682665705680847,
0.10806874185800552,
0.32554376125335693,
-0.30674245953559875,
0.33607620000839233,
-0.030324500054121017,
0.35765981674194336,
0.13774673640727997,
0.043140701949596405,
0.31480300426483154,
-0.5062228441238403,
0.18858397006988525,
-0.24727192521095276,
-0.30248504877090454,
0.625011682510376,
-0.5707796812057495,
-0.7191012501716614,
-0.4674209952354431,
-0.3748702108860016,
0.32100483775138855,
0.5454379916191101,
-0.21927790343761444,
0.3133285641670227,
0.5132277607917786,
0.3106411397457123,
0.03879119083285332,
0.09246734529733658,
0.8139851093292236,
0.5623404383659363,
-0.18484386801719666,
0.6809626221656799,
0.46473127603530884,
-0.17686383426189423,
-0.7983728051185608,
0.04692314565181732,
-0.18399973213672638,
-0.8740121126174927,
0.154924675822258,
0.31254228949546814,
-0.6567022204399109,
-0.2123253047466278,
-0.014330670237541199,
-0.6321411728858948,
-0.29356977343559265,
-0.026033278554677963,
0.12565091252326965,
-0.34165674448013306,
0.13030512630939484,
0.5063044428825378,
-0.2642671465873718,
-0.07026940584182739,
0.42533281445503235,
0.029269367456436157,
0.3776269853115082,
0.38813647627830505,
-0.6090501546859741,
0.18742960691452026,
0.9950953125953674,
-0.5460097193717957,
-0.37999439239501953,
0.60052090883255,
0.19540159404277802,
-0.489539235830307,
-0.5875729322433472,
-0.05848688259720802,
-0.07748381793498993,
-0.349020391702652,
0.5127221345901489,
0.1926783174276352,
-0.1392359435558319,
0.21011562645435333,
-0.3897308111190796,
-0.10208532959222794,
0.09121093899011612,
0.4386982321739197,
-0.06312613934278488,
0.14488531649112701,
-0.015142000280320644,
-0.13815376162528992,
-0.3584323227405548,
-0.008619630709290504,
0.21551939845085144,
0.10608803480863571,
0.03105187974870205,
-0.07414045184850693,
-0.053100984543561935,
0.5526003241539001,
-0.08377889543771744,
0.26436683535575867,
-0.24548162519931793,
0.23000837862491608,
0.1342201828956604,
-0.9492478370666504,
0.16755035519599915,
-0.5025498867034912,
0.009911982342600822,
-0.7711928486824036,
-0.05292998254299164,
-0.054225947707891464,
0.2581092119216919,
-0.38443243503570557,
-0.43526381254196167,
-0.6927841901779175,
-0.27854374051094055,
-0.015955600887537003,
-0.2795417606830597,
0.01251167617738247,
0.3989274799823761,
0.1409766525030136,
-0.2961677014827728,
0.3407091498374939,
-1.0021647214889526,
-0.22120563685894012,
0.5809220671653748,
0.7214205861091614,
-0.33309170603752136,
-0.03708072751760483,
0.229214608669281,
-0.38424476981163025,
-0.5602386593818665,
0.23933471739292145,
0.4560678005218506,
0.24166235327720642,
-0.2665858268737793,
0.07653757184743881,
-0.4783862829208374,
-0.28437304496765137,
0.421749472618103,
0.021536467596888542,
-0.2048177421092987,
0.18086397647857666,
0.41604816913604736,
-0.38246285915374756,
0.35698917508125305,
0.1850801557302475,
-0.012403489090502262,
-0.5120948553085327,
0.25182873010635376,
0.20997664332389832,
-0.07079317420721054,
-0.33035123348236084,
-0.482288122177124,
0.42748111486434937,
0.6759613752365112,
-0.5298124551773071,
0.11720073223114014,
0.16574494540691376,
0.03380516543984413,
-0.23310290277004242,
-0.011826951988041401,
0.6418907046318054,
-0.09159665554761887,
-0.22079338133335114,
0.1514327973127365,
-0.3786897361278534,
0.3971427381038666,
0.4301438629627228,
-0.8899273872375488,
-0.20808397233486176,
0.187745600938797,
-0.5148676633834839,
-0.23288512229919434,
0.03109229914844036,
0.1487041562795639,
-0.21828731894493103,
0.08573523908853531,
-0.09065866470336914,
0.39908939599990845,
-0.41822436451911926,
0.6649187207221985,
-0.08531064540147781,
0.5068936347961426,
-0.2320484071969986,
-0.1554735004901886,
-0.11176149547100067,
1.5157830715179443,
0.6003611087799072,
-0.431397020816803,
-0.4697082042694092,
-0.07367521524429321,
0.49732664227485657,
-0.02223147265613079,
0.010261285118758678,
0.30706027150154114,
0.8519699573516846,
-0.06851855665445328,
-0.21092505753040314,
-0.3763982653617859,
-0.23265571892261505,
0.42186206579208374,
-0.3651810586452484,
-0.2612488269805908,
-0.3758198618888855,
-0.03497013449668884,
0.758518636226654,
-0.07460881769657135,
-0.5232084393501282,
-0.5090917348861694,
0.36083248257637024,
-0.060183290392160416,
-0.03796021267771721,
-0.18292121589183807,
0.5833180546760559,
0.5775431394577026,
0.28505203127861023,
0.3922303318977356,
-0.031873367726802826,
-0.04191207513213158,
0.1299845576286316,
0.06610150635242462,
-0.38495877385139465,
-0.5058397054672241,
-0.07027037441730499,
-0.38564759492874146,
0.3610484004020691,
-0.611696720123291,
0.2386866956949234,
-0.5450183749198914,
0.18925774097442627,
-0.25376081466674805,
0.11282353848218918,
0.08220351487398148,
-0.6210213899612427,
-0.02048143371939659,
-0.5124162435531616,
0.5053995847702026,
0.19277578592300415,
0.15043120086193085,
0.16439181566238403,
-0.7125372290611267,
-0.43364784121513367,
0.5730981230735779,
0.5679611563682556,
-0.7744799852371216,
0.3135916292667389,
0.6114170551300049,
0.4875946640968323,
-0.033175624907016754,
-0.1797812581062317,
-0.2794811725616455,
0.16219763457775116,
-0.13401010632514954,
0.20823964476585388,
0.32894954085350037,
-0.15927757322788239,
0.12516643106937408,
0.17305411398410797,
-0.1884433776140213,
0.573432207107544,
0.29857760667800903,
-0.010933468118309975,
0.26290908455848694,
0.09724780917167664,
0.006755980663001537,
0.008490428328514099,
0.10505719482898712,
0.171038419008255,
-0.5514129996299744,
-0.22613975405693054,
0.46367961168289185,
0.5602871775627136,
0.6487610340118408,
-0.14509965479373932,
0.3304993212223053,
0.008135390467941761,
0.07505026459693909,
-0.4192926287651062,
-0.20772212743759155,
-0.5501534938812256,
0.47730863094329834,
0.7020172476768494,
0.32653793692588806,
-0.4010345935821533,
0.16480214893817902,
0.13080644607543945,
0.4411996901035309,
0.7975946664810181,
0.24924610555171967,
-0.5083405375480652,
0.5458152890205383,
0.31378746032714844,
0.10480280965566635,
-0.14458756148815155,
0.03882055729627609,
-0.6432269811630249,
0.06493812054395676,
0.588537871837616,
-0.2843455970287323,
0.08522436022758484,
-0.022846434265375137,
-0.20957303047180176,
0.4813325107097626,
-0.1567530333995819,
-0.010170786641538143,
-0.19713862240314484,
-0.1238797977566719,
0.1657441258430481,
-0.1619778424501419,
0.11978782713413239,
-0.04171769693493843,
0.10504822432994843,
0.3569227457046509,
-0.39590713381767273,
0.07846185564994812,
-0.06426970660686493,
-0.3325158357620239,
-0.11225706338882446,
0.1976596862077713,
-0.08874276280403137,
0.209987610578537,
-0.3199397027492523,
-0.08137241750955582,
-0.13978169858455658,
-0.38140803575515747,
-0.4279186427593231,
0.09257818013429642,
-0.6428852081298828,
-0.1266065090894699,
0.07580790668725967,
0.40887346863746643,
0.1499394178390503,
-0.7370470762252808,
0.019701937213540077,
0.06708454340696335,
0.08544523268938065,
0.07106746733188629,
0.2721223533153534,
0.6839074492454529,
0.15504857897758484,
0.165469229221344,
-0.17186251282691956,
0.5293282866477966,
-0.1751929074525833,
0.3596002757549286,
-0.3195665180683136,
0.5584277510643005,
-0.7079499363899231,
-0.10735834389925003,
-0.34466609358787537,
-0.20669445395469666,
1.1275583505630493,
0.6619625687599182,
-0.2735128700733185,
0.15618553757667542,
0.41470661759376526,
0.5181556344032288,
-0.26994526386260986,
-0.604927122592926,
0.17366160452365875,
-0.34799835085868835,
-0.025354210287332535,
-0.1775209605693817,
0.27290400862693787,
0.02239205129444599,
0.011589078232645988,
-0.15242868661880493,
0.5955703854560852,
0.6142585873603821,
-0.6667107343673706,
0.18802858889102936,
0.13516859710216522,
0.12024523317813873,
-0.5416554808616638,
0.35815301537513733,
-0.009243295527994633,
0.35022568702697754,
-0.3921838700771332,
-0.08769165724515915,
-0.021761570125818253,
-0.12813067436218262,
0.07714664191007614,
0.08433510363101959,
0.4776676893234253,
0.1976647526025772,
-0.2068951576948166,
-0.322995126247406,
-0.07966235280036926,
-0.5452031493186951,
-0.6486049294471741,
0.3491850197315216,
-0.032085880637168884,
-0.7299739122390747,
0.08033928275108337,
0.37164318561553955,
-0.3363657593727112,
0.11268823593854904,
-0.14927507936954498,
-0.1688500940799713,
-0.2657472491264343,
-0.23396727442741394
] |
Pregnancy-associated malaria (PAM) is caused by Plasmodium falciparum-infected erythrocytes (IEs) that bind to chondroitin sulphate A (CSA) in the placenta by PAM-associated clonally variant surface antigens (VSA). Pregnancy-specific VSA (VSA(PAM)), which include the PfEMP1 variant VAR2CSA, are targets of IgG-mediated protective immunity to PAM. Here, we report an investigation of the specificity of naturally acquired immunity to PAM, using eight human monoclonal IgG1 antibodies that react exclusively with intact CSA-adhering IEs expressing VSA(PAM). Four reacted in Western blotting with high-molecular-weight (> 200 kDa) proteins, while seven reacted with either the DBL3-X or the DBL5-ε domains of VAR2CSA expressed either as Baculovirus constructs or on the surface of transfected Jurkat cells. We used a panel of recombinant antigens representing DBL3-X domains from P. falciparum field isolates to evaluate B-cell epitope diversity among parasite isolates, and identified the binding site of one monoclonal antibody using a chimeric DBL3-X construct. Our findings show that there is a high-frequency memory response to VSA(PAM), indicating that VAR2CSA is a primary target of naturally acquired PAM-specific protective immunity, and demonstrate the value of human monoclonal antibodies and conformationally intact recombinant antigens in VSA characterization. | [
-0.0024973158724606037,
0.002218849491328001,
-0.0016901219496503472,
0.017122916877269745,
0.01042935997247696,
-0.0028514438308775425,
0.009587591513991356,
0.0159460436552763,
-0.006939878221601248,
-0.0023353882133960724,
-0.00789313018321991,
-0.000783152412623167,
-0.016844041645526886,
0.026349972933530807,
0.0022345499601215124,
-0.03499922156333923,
-0.02860846556723118,
0.015179467387497425,
0.014811755158007145,
0.028977151960134506,
0.012447785586118698,
-0.003708761418238282,
0.008961114101111889,
0.0023737968876957893,
0.015231896191835403,
0.016363680362701416,
0.02548523247241974,
-0.00816534273326397,
-0.027787161991000175,
0.00817006453871727,
0.01823911815881729,
0.002986376406624913,
-0.0003969472600147128,
-0.022846868261694908,
-0.00706204678863287,
-0.02230617217719555,
-0.005437865853309631,
0.01088559441268444,
0.006964228115975857,
-0.006827795412391424,
-0.014509291388094425,
-0.013958510011434555,
0.001723153400234878,
-0.0037162622902542353,
-0.004974270239472389,
-0.00996717531234026,
-0.002522421069443226,
0.0025795174296945333,
-0.0034599367063492537,
0.0035870952997356653,
-0.008873027749359608,
-0.007029586471617222,
-0.007024016231298447,
-0.029110578820109367,
-0.005012388341128826,
-0.012122618034482002,
0.014567424543201923,
0.003962433431297541,
0.015794016420841217,
-0.008046643808484077,
-0.00552563089877367,
-0.009788215160369873,
-0.013727356679737568,
0.000011145137250423431,
-0.021726062521338463,
-0.06739126145839691,
0.04779127985239029,
-0.024684973061084747,
-0.01677733287215233,
0.0019384287297725677,
0.012934993952512741,
0.005656667985022068,
-0.01101718470454216,
0.013927701860666275,
-0.01857784390449524,
-0.030870722606778145,
-0.011111481115221977,
-0.008362473919987679,
-0.02634812332689762,
0.043172091245651245,
-0.022050030529499054,
-0.00963857676833868,
-0.005557656288146973,
-0.003824083134531975,
-0.0024181343615055084,
0.005243878811597824,
-0.02711687609553337,
0.004613243509083986,
-0.023988259956240654,
-0.017041660845279694,
0.00339472945779562,
0.03617384657263756,
-0.03630036488175392,
-0.002823752351105213,
-0.002610623836517334,
-0.012547720223665237,
0.00668565696105361,
0.0009440642315894365,
-0.00027952948585152626,
-0.003322996199131012,
-0.011163972318172455,
-0.01168598048388958,
0.014326492324471474,
-0.03698118031024933,
-0.010541270487010479,
0.0024383901618421078,
-0.012464880011975765,
-0.018686311319470406,
0.013086613267660141,
0.011486931703984737,
-0.014357168227434158,
0.011102106422185898,
0.000403563492000103,
0.026059266179800034,
-0.014333701692521572,
0.02597283199429512,
0.00811910629272461,
0.00807849783450365,
0.012754750438034534,
-0.01576462760567665,
-0.008058449253439903,
-0.011953918263316154,
0.0034921406768262386,
0.03700382634997368,
-0.0017956160008907318,
0.005529405549168587,
0.03000185266137123,
0.006398699712008238,
0.007017122581601143,
0.00005392578896135092,
-0.006106172688305378,
0.009539480321109295,
-0.006657611578702927,
0.008281261660158634,
0.004888726398348808,
0.017134103924036026,
0.011383874341845512,
-0.020199593156576157,
-0.015111064538359642,
-0.014466073364019394,
-0.00982429925352335,
0.012450839392840862,
-0.0017065017018467188,
0.007212935946881771,
-0.01625257544219494,
0.006932047661393881,
-0.026789765805006027,
0.006611264310777187,
-0.00611847173422575,
0.01188308373093605,
0.011824874207377434,
-0.026192914694547653,
-0.014027715660631657,
-0.008499310351908207,
-0.025015586987137794,
-0.011102501302957535,
-0.00027116364799439907,
-0.004636835772544146,
-0.005884006153792143,
0.013728859834372997,
-0.0017609462374821305,
0.0011531346244737506,
-0.010898685082793236,
0.009391119703650475,
0.0015907320193946362,
0.0016283153090626001,
0.007314332760870457,
-0.00939648225903511,
0.008986961096525192,
0.008452405221760273,
0.0003985360963270068,
-0.008882855996489525,
0.0040413374081254005,
0.0026546823792159557,
-0.002282168949022889,
-0.002546041738241911,
0.01368710771203041,
0.004675139673054218,
-0.023176563903689384,
0.06666434556245804,
-0.033304598182439804,
-0.0006185984238982201,
-0.018688756972551346,
-0.01277200784534216,
0.032773662358522415,
-0.031959179788827896,
0.021570127457380295,
-0.010371155105531216,
0.005176657345145941,
0.004682107362896204,
0.0020605050958693027,
-0.02052398771047592,
-0.01490480825304985,
0.0352090559899807,
-0.019613206386566162,
0.002406416228041053,
-0.002823019400238991,
0.016544677317142487,
-0.006855451501905918,
0.013991935178637505,
-0.0029534052591770887,
-0.002266660798341036,
0.01444257516413927,
-0.015889419242739677,
0.02552470937371254,
0.016682974994182587,
-0.025178775191307068,
0.022883549332618713,
-0.029585566371679306,
0.01090487465262413,
0.017430445179343224,
-0.011674664914608002,
-0.0034722252748906612,
-0.011138515546917915,
0.005926226265728474,
-0.004150796681642532,
-0.012570488266646862,
-0.009829600341618061,
-0.010873666033148766,
-0.010748038999736309,
-0.006132649257779121,
0.028444577008485794,
-0.01219678483903408,
0.015046287328004837,
0.023892566561698914,
-0.006659081671386957,
0.023512566462159157,
0.007380452938377857,
0.023073576390743256,
0.014397157356142998,
-0.015964657068252563,
-0.03196607157588005,
-0.014628473669290543,
0.007011091336607933,
-0.006365148816257715,
0.0009159278124570847,
0.016370031982660294,
-0.017998116090893745,
0.01326465979218483,
-0.01832476444542408,
-0.0030749088618904352,
-0.0009464283939450979,
0.01909644715487957,
0.006005288101732731,
0.02306932955980301,
-0.006887199357151985,
0.00578329199925065,
-0.0018632416613399982,
-0.003051937557756901,
-0.024722909554839134,
0.009150875732302666,
0.004317900165915489,
-0.003162507899105549,
-0.03104637935757637,
0.038678817451000214,
-0.009600680321455002,
0.025514855980873108,
0.013683057390153408,
0.024305876344442368,
-0.013638260774314404,
-0.0007648997125215828,
0.007189675234258175,
-0.02225605398416519,
-0.01579226553440094,
0.023839419707655907,
0.030589820817112923,
-0.01263994351029396,
0.010416847653687,
-0.010794940404593945,
-0.011467766016721725,
0.010529739782214165,
-0.0013849352253600955,
-0.007980422116816044,
-0.08187952637672424,
-0.007709783501923084,
-0.016877107322216034,
-0.02064692974090576,
0.0021559782326221466,
0.018339481204748154,
-0.0036772715393453836,
-0.014917292632162571,
-0.009777450002729893,
0.004491762258112431,
0.015294319950044155,
-0.0009243616368621588,
-0.00596765149384737,
-0.010533250868320465,
0.03336775302886963,
0.0014459462836384773,
0.0019998278003185987,
0.006797573529183865,
-0.001089201308786869,
-0.0006094512064009905,
0.007958102971315384,
0.010821044445037842,
0.02426784485578537,
-0.009179532527923584,
-0.010229581966996193,
0.008491791784763336,
-0.021736696362495422,
0.0065211085602641106,
0.01648928038775921,
-0.00011291669216006994,
-0.002399807097390294,
-0.010009183548390865,
0.010139059275388718,
0.009667152538895607,
0.008861193433403969,
0.0004574442282319069,
-0.01643233746290207,
0.009370854124426842,
0.0020008841529488564,
0.01003905851393938,
-0.029429731890559196,
0.010524564422667027,
0.02507687546312809,
0.0092969611287117,
0.010592675767838955,
0.009153174236416817,
0.013460763730108738,
0.031106114387512207,
0.015634799376130104,
-0.02541603520512581,
-0.008706783875823021,
0.0005770539864897728,
0.04345010221004486,
0.01596059836447239,
-0.012521045282483101,
-0.012981416657567024,
0.0017269710078835487,
0.01300103310495615,
-0.002337159588932991,
-0.01488184742629528,
-0.02018526941537857,
-0.01526685245335102,
0.028336437419056892,
0.02185645140707493,
-0.034122440963983536,
-0.0022546472027897835,
0.014558353461325169,
-0.01565638929605484,
-0.003056639339774847,
0.009503166191279888,
0.022646505385637283,
0.013395372778177261,
-0.02147267386317253,
-0.007516007870435715,
0.0028130861464887857,
0.0011078885290771723,
-0.00836634635925293,
-0.00933865737169981,
-0.018872251734137535,
0.000734475557692349,
-0.022366413846611977,
0.005665506701916456,
0.0017375373281538486,
0.007547644432634115,
-0.011582392267882824,
-0.000633276766166091,
0.011606050655245781,
0.021310172975063324,
0.0004757725400850177,
-0.01523052528500557,
0.03759769722819328,
0.026175204664468765,
-0.003222092753276229,
0.01578909531235695,
0.0052701253443956375,
0.028427571058273315,
-0.017165236175060272,
0.0015792283229529858,
-0.002174888039007783,
0.006328046787530184,
-0.006720947567373514,
-0.0010138202924281359,
-0.006077568978071213,
-0.005867252126336098,
-0.03800409287214279,
0.007608418352901936,
0.0009146431693807244,
-0.009507915005087852,
-0.01140914298593998,
-0.0006085990462452173,
-0.008054466918110847,
-0.009996925480663776,
0.00203796848654747,
0.011220073327422142,
0.008806543424725533,
-0.011519636027514935,
-0.013366540893912315,
-0.00039390416350215673,
0.0726441890001297,
-0.01647547446191311,
-0.004882416687905788,
-0.006679750978946686,
0.012567222118377686,
-0.029926609247922897,
0.007186583708971739,
0.00030939653515815735,
-0.006661246530711651,
0.024049855768680573,
0.012163177132606506,
-0.010934318415820599,
-0.008195944130420685,
-0.01177460327744484,
-0.03686743229627609,
0.0027585322968661785,
-0.003346393583342433,
-0.010830097831785679,
0.008030281402170658,
0.033375516533851624,
-0.007475666236132383,
-0.010071846656501293,
-0.008396115154027939,
0.006703834980726242,
-0.013728708028793335,
0.028568346053361893,
0.04323070868849754,
-0.013228069990873337,
-0.02017005905508995,
0.008385494351387024,
0.0018888000631704926,
0.037085965275764465,
-0.010891675017774105,
0.00017074041534215212,
-0.005046781152486801,
-0.015130653977394104,
-0.027943946421146393,
0.0036698360927402973,
-0.003921797964721918,
-0.01334487646818161,
0.019210048019886017,
-0.01613227277994156,
-0.008901825174689293,
0.004461474251002073,
-0.011476295068860054,
-0.011861744336783886,
0.001975818071514368,
-0.009111279621720314,
0.0059564970433712006,
-0.005905038211494684,
-0.00024621753254905343,
0.008916743099689484,
0.004173807799816132,
0.014913637191057205,
-0.014707162976264954,
0.02146870829164982,
-0.008000792004168034,
-0.00469091534614563,
0.00006903382018208504,
-0.0075039067305624485,
-0.0024717391934245825,
-0.018880698829889297,
0.021655013784766197,
0.008429810404777527,
0.003897265996783972,
-0.0031151985749602318,
-0.005047567654401064,
0.008753163740038872,
-0.012664602138102055,
-0.008553978055715561,
0.004173343535512686,
-0.027850240468978882,
-0.0036795747000724077,
-0.0008955236990004778,
-0.03778240457177162,
-0.011981155723333359,
-0.005296168848872185,
-0.0014424684923142195,
-0.0195634588599205,
0.0033116962295025587,
-0.015997059643268585,
-0.020764213055372238,
-0.0003698061336763203,
0.000905246939510107,
-0.01615522988140583,
-0.002266892232000828,
-0.010544002056121826,
-0.07546569406986237,
0.008012006059288979,
-0.007761014625430107,
-0.0015072659589350224,
0.012111175805330276,
-0.027653755620121956,
-0.02021942101418972,
0.014297032728791237,
-0.017659418284893036,
-0.006400283891707659,
0.018559932708740234,
-0.019235903397202492,
0.014418194070458412,
-0.0038094623014330864,
0.012483601458370686,
0.02800098806619644,
0.005408372730016708,
-0.025774184614419937,
-0.015379756689071655,
-0.00996299460530281,
-0.0030940475407987833,
0.01966952346265316,
-0.020229004323482513,
0.010444914922118187,
-0.008253864012658596,
-0.08173005282878876,
-0.02230607159435749,
0.009615018963813782,
0.004580873996019363,
-0.012770776636898518,
0.019393524155020714,
0.0009063056204468012,
-0.02180921658873558,
-0.002838577376678586,
-0.011378223076462746,
-0.004780877381563187,
-0.013943269848823547,
0.03196219354867935,
-0.028003212064504623,
0.0005832563620060682,
-0.007964236661791801,
0.019454672932624817,
-0.022659558802843094,
0.01736341044306755,
0.03972294181585312,
0.004466214682906866,
0.021718498319387436,
-0.006522105075418949,
-0.004562081769108772,
-0.011449368670582771,
-0.004805956967175007,
-0.004473784938454628,
0.014557261019945145,
0.005265386775135994,
-0.0208114143460989,
-0.00731102516874671,
-0.014482437632977962,
-0.0239404384046793,
-0.0147573696449399,
-0.016901053488254547,
-0.004290413111448288,
0.009948596358299255,
0.0007492028526030481,
0.01875028945505619,
-0.013737260363996029,
-0.0031851581297814846,
-0.0009588189423084259,
0.0023899669758975506,
0.011461346410214901,
-0.031017187982797623,
0.014537470415234566,
0.009438549168407917,
-0.016455750912427902,
0.013898050412535667,
-0.00753997964784503,
0.00843444000929594,
-0.028709065169095993,
0.0002433673944324255,
0.005180110223591328,
0.009088131599128246,
-0.008584881201386452,
-0.000001533087925054133,
0.0006065736524760723,
0.0020689640659838915,
0.014086071401834488,
0.0024326329585164785,
0.01726367697119713,
0.01618161052465439,
0.0717131718993187,
-0.004486417397856712,
0.008433355018496513,
-0.01436652708798647,
-0.004931712057441473,
0.009911998175084591,
0.000108679523691535,
0.01663805916905403,
0.007388567551970482,
-0.016684463247656822,
0.01264459639787674,
-0.005658653564751148,
-0.0022897138260304928,
0.01391974464058876,
0.015542822889983654,
0.004366420209407806,
-0.008498244918882847,
-0.012891128659248352,
0.015142388641834259,
-0.023016639053821564,
0.005348950624465942,
0.0039468854665756226,
0.0007758450228720903,
-0.02224322222173214,
0.03594779223203659,
-0.012372303754091263,
-0.023647213354706764,
0.0036669091787189245,
-0.03398992493748665,
-0.006298035383224487,
0.010593917220830917,
0.010653410106897354,
0.003098168410360813,
0.020369315519928932,
-0.0009766239672899246,
0.021821361035108566,
0.016960322856903076,
0.011698214337229729,
0.0037295976653695107,
0.028027189895510674,
-0.013592743314802647,
-0.024186894297599792,
-0.004172381013631821,
-0.010703027248382568,
0.005250213667750359,
-0.02795586735010147,
-0.0023910359013825655,
0.016170552000403404,
0.01989591494202614,
-0.0015953588299453259,
0.01146748661994934,
0.01587511971592903,
-0.0017827933188527822,
-0.013742582872509956,
0.01981876790523529,
0.0032071336172521114,
-0.01653827354311943,
0.01326335035264492,
-0.010903863236308098,
0.005894503556191921,
0.020557072013616562,
-0.017435429617762566,
0.03623294457793236,
-0.008769329637289047,
0.027068279683589935,
-0.005559878423810005,
0.005208740010857582,
-0.012633262202143669,
0.0016562072560191154,
0.011322472244501114,
0.0001614741049706936,
-0.007662700489163399,
0.012941760942339897,
-0.007568718399852514,
0.03180728107690811,
0.022858712822198868,
-0.005075017921626568,
0.00029160850681364536,
0.00503266928717494,
0.006340885069221258,
-0.01493679266422987,
-0.013226581737399101,
0.026349861174821854,
-0.0055684675462543964,
0.0018620669143274426,
0.009910576976835728,
0.018994135782122612,
-0.011149267666041851,
-0.0034339362755417824,
0.005424651317298412,
-0.01107940822839737,
0.018275853246450424,
0.0034273136407136917,
0.002178655471652746,
0.01025450136512518,
0.03393074870109558,
0.015321008861064911,
0.002817395608872175,
0.014996353536844254,
-0.002907484769821167,
0.01973133534193039,
-0.02135651372373104,
-0.04209806025028229,
0.01976788602769375,
0.010244081728160381,
0.0020100341644138098,
0.025230973958969116,
-0.028016356751322746,
0.010054268874228,
-0.009214836172759533,
-0.00400962121784687,
-0.0036159371957182884,
0.01790691167116165,
0.02476136013865471,
0.02230537310242653,
0.03530263528227806,
-0.0058496566489338875,
0.027416780591011047,
0.006895243190228939,
-0.011910547502338886,
-0.006518347188830376,
-0.016726724803447723,
-0.008018013089895248,
0.015462253242731094,
-0.02658582665026188,
-0.011386452242732048,
-0.00899423286318779,
0.004623520188033581,
-0.00405407277867198,
-0.016529295593500137,
0.020236622542142868,
-0.012172053568065166,
-0.0021981860045343637,
0.0037100594490766525,
-0.006622387561947107,
-0.009282621555030346,
0.006471844390034676,
-0.005478822160512209,
-0.01139091793447733,
-0.016658715903759003,
0.014265590347349644,
0.00893443450331688,
0.0023531203623861074,
-0.0024520917795598507,
0.006008107215166092,
-0.026090335100889206,
0.022139858454465866,
-0.017453882843255997,
0.012045244686305523,
0.016433633863925934,
-0.011485748924314976,
0.003691098652780056,
-0.007503076456487179,
-0.010804463177919388,
0.008750430308282375,
0.006012735888361931,
0.0007108970312401652,
-0.016331464052200317,
0.009132595732808113,
0.0017475029453635216,
-0.009649931453168392,
-0.019166529178619385,
0.0037399455904960632,
-0.010096041485667229,
0.010891363956034184,
0.02256958559155464,
-0.009434773586690426,
-0.01239529438316822,
-0.009106824174523354,
-0.027523349970579147,
-0.01366475597023964,
-0.004963425453752279,
-0.02509484812617302,
0.007113741710782051,
-0.019977614283561707,
-0.005232851020991802,
-0.011267198249697685,
-0.013712644577026367,
-0.0028651347383856773,
0.0203196182847023,
-0.005127551034092903,
0.015581903047859669,
0.016187794506549835,
-0.008762221783399582,
-0.021145585924386978,
0.00236790650524199,
-0.006210182327777147,
-0.0008175887633115053,
0.014348581433296204,
0.002740771509706974,
-0.002602117136120796,
-0.02533404529094696,
0.000401575758587569,
-0.004747016821056604,
-0.012533857487142086,
-0.002116917632520199,
0.0026657870039343834,
0.013990484178066254,
0.002835239050909877,
0.0027526114135980606,
-0.005295326933264732,
-0.006965007167309523
] | [
-0.213299959897995,
-0.2079753279685974,
-0.13771365582942963,
-0.13678377866744995,
-0.12106606364250183,
0.46612367033958435,
0.20942318439483643,
0.1647140383720398,
-0.3242754340171814,
-0.2512963116168976,
0.12396865338087082,
-0.22057673335075378,
-0.5491421222686768,
0.12037085741758347,
-0.17578072845935822,
0.8724851012229919,
0.33690476417541504,
0.6572592258453369,
-0.2692438066005707,
-0.7183857560157776,
-0.3641970455646515,
-0.6570349931716919,
0.049320779740810394,
0.2806621193885803,
0.011316495947539806,
0.06975188851356506,
0.5043432712554932,
-0.05312255024909973,
0.41049373149871826,
-0.5963060855865479,
0.04713139683008194,
0.5259404182434082,
0.4374913275241852,
0.29767724871635437,
-0.23865270614624023,
0.20475539565086365,
-0.8546400666236877,
-0.10152842104434967,
0.01674726977944374,
-0.32771292328834534,
-0.7302283644676208,
-0.6805130839347839,
-0.02784353867173195,
0.23688577115535736,
0.2855706512928009,
-0.5322907567024231,
-1.007684588432312,
0.8977146148681641,
-0.28807491064071655,
0.09929144382476807,
-0.42836883664131165,
0.2447797656059265,
0.3157675862312317,
0.31901755928993225,
0.3218534588813782,
0.16512811183929443,
-0.5768358707427979,
0.19030116498470306,
-0.039699289947748184,
-0.8901068568229675,
-0.03798024356365204,
0.142973393201828,
0.10475991666316986,
0.020986109972000122,
-0.16968689858913422,
0.8414146304130554,
0.12675374746322632,
0.037135981023311615,
-0.32791152596473694,
-0.5770059823989868,
-0.42600810527801514,
-0.6032046675682068,
-0.18195569515228271,
0.38627922534942627,
-0.1454547494649887,
-0.24835212528705597,
-0.415944904088974,
-0.425558477640152,
0.23036201298236847,
0.40463170409202576,
-0.16345389187335968,
0.5532499551773071,
0.45252612233161926,
-0.006724141538143158,
0.34807083010673523,
0.19515132904052734,
0.24359746277332306,
1.0475270748138428,
0.16158291697502136,
0.2566559612751007,
0.2359645813703537,
0.5858752727508545,
0.6166993975639343,
0.05383928492665291,
-0.10809897631406784,
0.4103110432624817,
-0.03185378387570381,
0.20629628002643585,
0.4907466471195221,
0.15010777115821838,
-0.3031160831451416,
0.05187692493200302,
-0.08041172474622726,
-0.3116302192211151,
-0.336789071559906,
-0.11089868098497391,
-0.010252704843878746,
-0.3965902626514435,
-0.4687362015247345,
-0.025323335081338882,
-0.7801745533943176,
0.08586698770523071,
-0.2631074786186218,
-0.37484607100486755,
-0.18543854355812073,
0.229385107755661,
0.026875458657741547,
-0.3358432352542877,
-0.23018836975097656,
-0.4986337721347809,
-0.31779491901397705,
0.6954389214515686,
-0.026169439777731895,
0.7248213887214661,
0.1467631608247757,
0.23168954253196716,
0.20984485745429993,
-0.021929623559117317,
-0.12775468826293945,
0.856244683265686,
0.14201614260673523,
0.5308010578155518,
-0.20110979676246643,
0.2741330564022064,
0.13510026037693024,
-0.20522218942642212,
0.012967565096914768,
0.6490108370780945,
0.859261155128479,
-0.1991545557975769,
-1.1500937938690186,
-0.37734752893447876,
-0.15339577198028564,
0.07217370718717575,
0.14082273840904236,
-0.30051806569099426,
0.03942103311419487,
0.09411845356225967,
-0.0728534460067749,
-0.4192703664302826,
0.22038152813911438,
-0.18579816818237305,
-0.42734095454216003,
0.03472175821661949,
-0.012251244857907295,
-0.2258765995502472,
0.08811086416244507,
-0.30339813232421875,
-0.10217133909463882,
0.21330900490283966,
0.7208983302116394,
0.2921433448791504,
-0.468637079000473,
0.12904398143291473,
0.007956737652420998,
0.14361411333084106,
-0.0663747489452362,
0.4398987591266632,
0.35487180948257446,
0.026163121685385704,
-0.4748467803001404,
-0.31533825397491455,
-0.303862988948822,
-0.6078259348869324,
-0.15807189047336578,
0.3125655949115753,
0.007614229805767536,
-0.31018856167793274,
0.2200562208890915,
0.4309310019016266,
-0.5533937811851501,
0.45013245940208435,
-0.10172713547945023,
-0.5756083130836487,
-0.03203023970127106,
-0.02645154669880867,
0.4590786397457123,
0.06629268825054169,
-0.0526178777217865,
0.1422916203737259,
-1.0151337385177612,
0.007017300929874182,
0.6122797727584839,
-0.17919613420963287,
1.1751337051391602,
-0.10586480796337128,
-0.8208726644515991,
1.3538610935211182,
0.5715054273605347,
-0.27493950724601746,
-0.25357353687286377,
0.31123146414756775,
0.431530624628067,
-0.12440026551485062,
-1.2064144611358643,
-0.1742761880159378,
-0.1422625184059143,
-0.2308548241853714,
-0.24799583852291107,
0.3078368902206421,
-0.1581908017396927,
-0.24733677506446838,
-0.045692671090364456,
-0.4438886046409607,
0.5437355637550354,
0.13885201513767242,
-0.1750456988811493,
-0.2741137742996216,
0.05681328475475311,
-0.09936925023794174,
0.028495650738477707,
-0.8526586294174194,
0.4780202805995941,
0.7521986365318298,
0.2761349081993103,
0.6608182787895203,
0.538006067276001,
0.20019876956939697,
0.8846970200538635,
-0.34970539808273315,
0.39337781071662903,
0.1677476018667221,
0.5789666175842285,
-0.516266405582428,
-0.20553818345069885,
0.21739210188388824,
0.1276322603225708,
-0.5146293044090271,
-0.49853935837745667,
0.030050810426473618,
0.3525075614452362,
0.812221884727478,
-0.2220635861158371,
-0.25750306248664856,
-0.2902555763721466,
-0.38226422667503357,
-0.6857715845108032,
-0.08216787874698639,
-0.7541351914405823,
0.06903760880231857,
0.3508276045322418,
0.6979543566703796,
0.19728955626487732,
0.08836494386196136,
-0.28885236382484436,
-0.05949797481298447,
-0.3517078161239624,
-0.05641261115670204,
0.3186104893684387,
-0.4142889380455017,
-0.11697005480527878,
0.30626481771469116,
0.3034523129463196,
0.6853728890419006,
0.33913367986679077,
-0.38682717084884644,
-0.7632008194923401,
-0.1907491236925125,
0.5195848345756531,
0.49904292821884155,
1.279388666152954,
-0.15754656493663788,
-0.9215389490127563,
-0.25942540168762207,
0.04085550084710121,
-0.7161568999290466,
0.035586949437856674,
0.6405721306800842,
-0.8067237138748169,
-0.4943695068359375,
0.02942834049463272,
-0.01573563553392887,
0.8321888446807861,
-0.46205413341522217,
-0.049117617309093475,
-0.19410428404808044,
-0.1284087598323822,
-0.5216924548149109,
-0.5963555574417114,
-0.5002440810203552,
-0.22788487374782562,
0.765030026435852,
-0.34449148178100586,
0.24080798029899597,
0.46397092938423157,
-0.5336745977401733,
0.23594428598880768,
0.7750207185745239,
0.941434919834137,
-0.16376250982284546,
0.33029505610466003,
0.10615354776382446,
-0.19463878870010376,
0.15167148411273956,
-0.13906089961528778,
-0.039745960384607315,
0.3631010949611664,
-0.12097785621881485,
-5.601535320281982,
-0.4030357301235199,
0.035284437239170074,
-0.07273311913013458,
-0.13412828743457794,
-0.05041440948843956,
1.373691439628601,
-0.2010713368654251,
0.4205881953239441,
0.41813284158706665,
0.39961886405944824,
0.4071164131164551,
0.01996009796857834,
-0.7475653886795044,
-0.31067854166030884,
0.38276106119155884,
-0.05875138193368912,
-0.6861633062362671,
0.8284159302711487,
-0.022329023107886314,
0.3967975974082947,
0.24972239136695862,
-0.15223275125026703,
0.4405125081539154,
-0.19194930791854858,
-0.14102348685264587,
-0.4772403836250305,
-0.14190395176410675,
-0.4757310748100281,
-0.2581079304218292,
0.005617381073534489,
-0.8161998987197876,
0.30904272198677063,
-0.0052877310663461685,
-0.3102319836616516,
-0.03931817784905434,
0.30948835611343384,
-0.44031718373298645,
-0.6839874386787415,
-0.27552366256713867,
0.0684722289443016,
-0.3615072965621948,
0.30057063698768616,
0.16972313821315765,
0.21698275208473206,
0.20093689858913422,
0.13070634007453918,
-0.1928246021270752,
0.06965892016887665,
0.986051619052887,
0.12017948180437088,
-0.08171903342008591,
0.4561520516872406,
0.5525378584861755,
0.27888426184654236,
0.16368743777275085,
-0.2110944241285324,
0.28383609652519226,
-0.5780211091041565,
0.39773762226104736,
-0.2700727880001068,
-0.0050534456968307495,
-0.39064523577690125,
-0.6134155988693237,
0.13121846318244934,
0.4166632294654846,
-0.5466817021369934,
-0.2883688509464264,
0.5203602910041809,
-0.2787921130657196,
-0.13227578997612,
0.020168976858258247,
0.3063146471977234,
-0.6334589123725891,
0.8044090270996094,
-0.9740895628929138,
-0.0276157408952713,
-0.04030763357877731,
-0.16323049366474152,
-0.5045556426048279,
-0.37675315141677856,
-0.7052241563796997,
0.3037729263305664,
-0.4421030580997467,
0.26964113116264343,
-0.3145557940006256,
-0.08867105096578598,
-0.2219487726688385,
-0.16370700299739838,
0.4764983355998993,
0.5308367013931274,
0.37114834785461426,
0.34718531370162964,
0.7635025382041931,
0.5678853392601013,
0.69834303855896,
0.2912923991680145,
1.0472018718719482,
0.8537819981575012,
-0.08408825099468231,
0.45654621720314026,
-0.2969309985637665,
-0.22010065615177155,
-0.683384120464325,
-0.07469374686479568,
0.1503288447856903,
-0.4014779329299927,
-0.303547739982605,
0.8697728514671326,
-0.7855694890022278,
0.5384286046028137,
0.27831119298934937,
-0.45478618144989014,
-0.3511640727519989,
0.6203005909919739,
0.0835341364145279,
0.2555517852306366,
0.951438307762146,
0.6013256907463074,
-0.3637128472328186,
0.15328967571258545,
0.10013812780380249,
-0.6627035737037659,
0.39572611451148987,
0.27659523487091064,
-0.021762005984783173,
0.1776954084634781,
0.565190315246582,
-0.30161696672439575,
-0.06654438376426697,
0.017426474019885063,
0.09483703225851059,
-0.23739923536777496,
-0.40850135684013367,
0.21784736216068268,
-0.20236967504024506,
-0.3505842387676239,
0.23132139444351196,
0.23002491891384125,
-0.018631480634212494,
0.02511553093791008,
0.00015455055108759552,
-0.41512730717658997,
0.07773248851299286,
-0.23756274580955505,
-0.04968249052762985,
-0.43952491879463196,
-0.14186127483844757,
-0.45292970538139343,
-0.23238438367843628,
0.0708635225892067,
-0.16199617087841034,
0.3170956075191498,
0.3025856018066406,
-0.8025861382484436,
0.09722010791301727,
0.726121187210083,
0.5823161005973816,
-0.0807362049818039,
-0.7253482341766357,
-0.055253297090530396,
-0.6635892987251282,
-0.8904258012771606,
-0.09887630492448807,
-0.6495789885520935,
0.03155714273452759,
0.3047511577606201,
-0.7054228186607361,
0.19214056432247162,
0.4082796275615692,
0.13465596735477448,
-0.14431855082511902,
-0.0019522540969774127,
0.2611232101917267,
0.01673240214586258,
0.0688491240143776,
-0.43745627999305725,
-0.19807329773902893,
0.0061609926633536816,
0.28999897837638855,
-0.3063698709011078,
-0.39428943395614624,
0.054579731076955795,
0.5013468265533447,
0.159176304936409,
0.1209607869386673,
-0.1080469936132431,
-0.3759628236293793,
-0.33589279651641846,
-0.049452874809503555,
0.10545209795236588,
0.32988718152046204,
0.16502970457077026,
-0.5789178609848022,
-0.22642669081687927,
0.3618842363357544,
-0.2278091311454773,
0.013387112878262997,
0.19962111115455627,
-0.16758430004119873,
-0.1817401796579361,
0.12290152162313461,
-0.27930232882499695,
0.3849587142467499,
0.027494242414832115,
-0.18109329044818878,
-0.4648435115814209,
0.0717383474111557,
-0.4711858332157135,
-0.6631460785865784,
-0.15083850920200348,
-0.3081616461277008,
0.020901288837194443,
0.8303911089897156,
-0.41874605417251587,
0.07410112768411636,
-0.5647031664848328,
-0.3858281970024109,
0.015775371342897415,
0.477882444858551,
0.12778373062610626,
0.09672456234693527,
-0.05192231759428978,
-0.00986304972320795,
-0.4646669030189514,
0.5876471996307373,
0.4950014352798462,
-1.6023612022399902,
0.4492091238498688,
0.16080829501152039,
0.16231445968151093,
-0.07537247240543365,
0.05993318930268288,
0.22753170132637024,
-0.4229777157306671,
-0.42640700936317444,
-0.12754957377910614,
0.024581199511885643,
0.3474438786506653,
0.6468104720115662,
-0.20145827531814575,
0.381128191947937,
-0.5943320393562317,
-0.19975198805332184,
0.4484984874725342,
0.24024881422519684,
0.22563226521015167,
-0.950895369052887,
-0.46741288900375366,
0.49207833409309387,
0.14279071986675262,
-0.042626023292541504,
0.25276774168014526,
0.4317072927951813,
0.9772242903709412,
-0.03509589284658432,
-0.40831178426742554,
-0.4931594431400299,
-0.2837246358394623,
-0.20225444436073303,
-0.23341861367225647,
0.061045438051223755,
-0.006441534496843815,
0.21812884509563446,
-0.1695367693901062,
-0.12846605479717255,
0.045993003994226456,
0.02451188676059246,
0.2522168755531311,
0.3904242217540741,
-0.11094869673252106,
-0.2524431347846985,
0.7469496130943298,
0.632271409034729,
0.13561193645000458,
0.15034323930740356,
-0.12505856156349182,
-0.01461283303797245,
0.5577490329742432,
0.539105236530304,
-0.2278093695640564,
-1.1194148063659668,
0.26548609137535095,
-0.3274848163127899,
0.6710174083709717,
-0.23006640374660492,
0.07480113953351974,
-0.7119995951652527,
-0.0738760381937027,
-0.038590140640735626,
0.02444549649953842,
0.5014570355415344,
-0.21167531609535217,
-0.4259474277496338,
-0.13123904168605804,
0.2755223512649536,
0.2581574320793152,
-0.05416715890169144,
-0.48672834038734436,
-0.5895437002182007,
-0.5839658975601196,
0.4953809976577759,
0.37413644790649414,
0.09681320190429688,
-0.5044004321098328,
-0.05301472917199135,
0.22997184097766876,
-0.13656093180179596,
-0.6747915148735046,
0.0560537725687027,
0.10515613853931427,
-0.23174022138118744,
0.45922958850860596,
-0.27517831325531006,
-0.28921353816986084,
0.5298078656196594,
-0.35450923442840576,
0.09803719818592072,
0.004732232075184584,
0.25020110607147217,
0.6072086095809937,
0.6327230930328369,
0.39856868982315063,
0.05344029515981674,
0.21421915292739868,
-0.0026399034541100264,
0.48396801948547363,
0.1654338836669922,
0.030964704230427742,
0.40300849080085754,
0.3079463839530945,
-0.00256883492693305,
-0.07470109313726425,
0.624546229839325,
0.36834460496902466,
-0.0004387700173538178,
-0.0604792982339859,
-0.7923650145530701,
-0.46081066131591797,
0.03654437139630318,
0.7750843167304993,
0.30794358253479004,
0.20660649240016937,
0.2978443503379822,
0.3639059364795685,
-0.014688260853290558,
0.2431579828262329,
0.07169209420681,
-0.08670341223478317,
-0.15909135341644287,
0.4295458495616913,
-0.25995972752571106,
-0.4321630001068115,
-0.1600303053855896,
-0.5211645364761353,
0.4173058271408081,
0.6246084570884705,
-0.3390853703022003,
-0.4812774956226349,
0.17280825972557068,
-0.6662379503250122,
-0.12282165884971619,
-0.04939509183168411,
0.7540637254714966,
0.23448200523853302,
-0.2730150520801544,
0.24179954826831818,
0.027166811749339104,
0.3330673575401306,
-0.1644907146692276,
0.45364323258399963,
-0.5593534708023071,
-0.5192670226097107,
0.5205682516098022,
0.5555745363235474,
-0.12147682160139084,
0.18983742594718933,
0.3972246050834656,
-0.07597995549440384,
0.4809027910232544,
-0.46393173933029175,
-0.07980816066265106,
-0.16812467575073242,
-0.4596726596355438,
-0.24862903356552124,
-0.4484633207321167,
-0.2847100496292114,
-0.05088098719716072,
-0.06954465061426163,
0.16849243640899658,
0.49791961908340454,
-0.068787582218647,
-0.1198742538690567,
0.07325457036495209,
-0.030290281400084496,
0.5394505262374878,
0.17888346314430237,
0.28799960017204285,
0.1160985603928566,
0.27515730261802673,
-0.17727506160736084,
0.40286827087402344,
-0.6248281002044678,
0.10318068414926529,
-0.6788541674613953,
0.5721369981765747,
-0.4589928686618805,
-0.03830062225461006,
-0.9829922914505005,
-0.330868661403656,
0.6799557209014893,
0.7061444520950317,
-0.009110718965530396,
0.23385848104953766,
0.32484325766563416,
0.21358750760555267,
0.33804404735565186,
-0.8475418090820312,
-0.3520791530609131,
-0.5434859395027161,
-0.22214558720588684,
-0.5299016833305359,
0.3932332694530487,
0.08775372803211212,
-0.2778280973434448,
0.18852266669273376,
0.8554405570030212,
0.5070958137512207,
-0.15235954523086548,
0.14533297717571259,
-0.3342096209526062,
0.6033596396446228,
-0.37540146708488464,
0.17793001234531403,
-0.377034991979599,
0.11456360667943954,
-0.35904020071029663,
0.3331758975982666,
0.5015904903411865,
-0.28053075075149536,
0.4358048141002655,
-0.7720279693603516,
-0.7640218138694763,
-0.4663427472114563,
0.20542727410793304,
0.011667275801301003,
-0.11591485887765884,
-0.4835934638977051,
-0.470826119184494,
-0.04150400683283806,
-0.19534334540367126,
-0.5905290842056274,
-0.46161478757858276,
-0.24587488174438477,
-0.34148967266082764,
-0.32676345109939575,
0.11961022764444351,
-0.18585602939128876,
-0.046028122305870056,
0.10685479640960693
] |
[
0.030699975788593292,
0.10140369832515717,
-0.04192632809281349,
0.06293141841888428,
-0.03267847001552582,
-0.12038351595401764,
0.035765983164310455,
-0.05915536358952522,
-0.008488839492201805,
-0.05911063775420189,
-0.05657084658741951,
-0.005575065966695547,
-0.05070307105779648,
0.06654473394155502,
-0.05232572928071022,
-0.10524960607290268,
-0.11025319993495941,
0.10980250686407089,
0.11460278183221817,
-0.11366231739521027,
-0.0736834928393364,
-0.014200853183865547,
0.03315950185060501,
-0.042415086179971695,
-0.18886972963809967,
0.04834016412496567,
-0.010257190093398094,
-0.013155662454664707,
-0.11621294915676117,
0.22128282487392426,
0.026432644575834274,
-0.0035340951289981604,
0.09944672882556915,
0.0506606251001358,
0.07618589699268341,
-0.1337132453918457,
-0.07806193083524704,
0.018981769680976868,
-0.056862808763980865,
-0.14643901586532593,
-0.16388945281505585,
-0.057634275406599045,
0.07937344908714294,
-0.0544847771525383,
-0.024052107706665993,
-0.07310523092746735,
-0.07155387103557587,
-0.10090649873018265,
-0.028452187776565552,
0.14460046589374542,
-0.05908972769975662,
-0.0028850892558693886,
-0.030829090625047684,
-0.06325825303792953,
-0.02312028780579567,
-0.15990810096263885,
-0.09092682600021362,
-0.016466086730360985,
0.06645786762237549,
0.04531364515423775,
-0.11512433737516403,
0.10278821736574173,
-0.23874814808368683,
-0.08993463963270187,
0.04214683547616005,
-0.06208702549338341,
0.19159553945064545,
0.06058281660079956,
0.04147198423743248,
0.04145164415240288,
0.08241380751132965,
0.07910601049661636,
-0.21460114419460297,
-0.04764945060014725,
-0.06004532054066658,
-0.05771621689200401,
0.04311008378863335,
0.029352186247706413,
-0.007787349633872509,
0.0667465552687645,
0.11730451881885529,
-0.036040034145116806,
0.0379948653280735,
0.08618149906396866,
0.09119251370429993,
-0.12663358449935913,
-0.027850864455103874,
-0.026794370263814926,
0.10444615036249161,
-0.19966867566108704,
-0.06711355596780777,
0.020024478435516357,
0.02054487355053425,
-0.07212473452091217,
-0.12159039080142975,
-0.23648804426193237,
-0.04011392965912819,
0.10453135520219803,
-0.08162038028240204,
-0.047898195683956146,
-0.14109919965267181,
-0.09871640801429749,
0.006453124340623617,
0.08454540371894836,
-0.20008768141269684,
0.031001994386315346,
0.3166082501411438,
-0.08357764780521393,
-0.06154737249016762,
0.05468873679637909,
-0.10438451170921326,
-0.043026577681303024,
0.039880186319351196,
-0.002967559266835451,
0.04125188663601875,
0.10730873048305511,
-0.031131744384765625,
0.07599066942930222,
0.11015765368938446,
0.2026078850030899,
0.0340835340321064,
-0.11498764902353287,
0.00341621832922101,
0.1823115050792694,
0.08721653372049332,
0.08886470645666122,
0.038886621594429016,
-0.14626866579055786,
-0.10826382040977478,
-0.10755138099193573,
-0.043079130351543427,
0.06791600584983826,
-0.08626728504896164,
-0.13008858263492584,
-0.06684456765651703,
-0.0757908821105957,
-0.12930254638195038,
0.10704216361045837,
-0.16803321242332458,
0.12600107491016388,
-0.04051733389496803,
0.056915540248155594,
0.09876076132059097,
0.05756385996937752,
0.12005363404750824,
-0.09532523900270462,
-0.0735682025551796,
0.04351639747619629,
0.12305520474910736,
-0.12239664793014526,
-0.03981996327638626,
-0.02161284163594246,
-0.10828825831413269,
-0.0646689310669899,
-0.03846750035881996,
0.19904725253582,
-0.03407208248972893,
-0.10436071455478668,
0.018596051260828972,
0.10414863377809525,
0.09536723792552948,
-0.014020226895809174,
0.04361536353826523,
0.028888408094644547,
-0.06593406200408936,
0.008343683555722237,
0.04160940647125244,
-0.011753213591873646,
-0.11578797549009323,
0.05167029798030853,
-0.06676144897937775,
0.1441592276096344,
-0.22843779623508453,
0.12496988475322723,
0.028016896918416023,
-0.05906530097126961,
0.17457708716392517,
0.05070481076836586,
-0.11385047435760498,
0.060045935213565826,
-0.09621882438659668,
0.05438654124736786,
0.03432608023285866,
0.15427951514720917,
0.11706224828958511,
-0.002386678010225296,
0.00803310889750719,
-0.07359828799962997,
0.15835100412368774,
0.017626335844397545,
-0.007624693680554628,
-0.04966338351368904,
-0.04089459404349327,
0.07255762070417404,
0.21151596307754517,
0.06603258103132248,
0.09396278113126755,
-0.018833069130778313,
0.02596215531229973,
0.07787297666072845,
0.0033172147814184427,
-0.03406890109181404,
-0.0378173291683197,
0.0016285512829199433,
0.17468418180942535,
0.14436595141887665,
0.07670074701309204,
-0.018170222640037537,
-0.12715241312980652,
0.011177051812410355,
0.04855913668870926,
0.05172306299209595,
-0.04483100771903992,
-0.031188545748591423,
0.21232262253761292,
-0.12014889717102051,
0.04454215243458748,
-0.006694146431982517,
-0.008590037934482098,
0.010534912347793579,
-0.005982778966426849,
-0.049038566648960114,
-0.03788432478904724,
-0.148992121219635,
-0.15680280327796936,
0.11952607333660126,
-0.03443474322557449,
-0.009466748684644699,
-0.17385894060134888,
0.06695250421762466,
-0.08063670247793198,
0.1111515536904335,
-0.05964672192931175,
-0.08919277042150497,
0.07400178909301758,
-0.08179539442062378,
0.010917145758867264,
-0.10002771019935608,
0.030084840953350067,
-0.05879339575767517,
0.15256229043006897,
-0.0588756687939167,
0.058464743196964264,
-0.06250129640102386,
-0.1272299885749817,
0.14816193282604218,
0.11261296272277832,
-0.20878300070762634,
0.07267408818006516,
-0.19025585055351257,
0.04558248072862625,
-0.06399069726467133,
0.09287825971841812,
-0.14967121183872223,
0.0832153856754303,
0.0884755551815033,
-0.07130222767591476,
-0.08636317402124405,
-0.062446922063827515,
-0.0917036235332489,
0.04213356599211693,
0.02685438096523285,
-0.07510712742805481,
0.14564858376979828,
-0.1311965137720108,
0.06008942797780037,
0.10980391502380371,
0.23106127977371216,
0.06301818042993546,
-0.11306808888912201,
0.4958252012729645,
-0.08599810302257538,
-0.10827255249023438,
-0.07431084662675858,
0.00557404151186347,
-0.010929758660495281,
0.19725823402404785,
0.07282532006502151,
0.12956568598747253,
0.12012496590614319,
-0.32143303751945496,
-0.003951505292207003,
0.031411223113536835,
0.2858768403530121,
0.007240592502057552,
-0.04573579132556915,
-0.15110504627227783,
-0.06919705122709274,
-0.05780123919248581,
0.045537661761045456,
0.08062059432268143,
0.05595998466014862,
-0.19111478328704834,
0.20023339986801147,
0.030304836109280586,
0.16707292199134827,
-0.019236214458942413,
0.14964352548122406,
-0.0109718581661582,
0.08966008573770523,
-0.1306983232498169,
-0.10273553431034088,
0.05057602375745773,
-0.10228367894887924,
-0.014037727378308773,
0.01175781711935997,
-0.19365377724170685,
0.07810384780168533,
-0.09055490046739578,
-0.024642886593937874,
-0.007601541467010975,
0.024362703785300255,
0.1254616379737854,
-0.048288214951753616,
0.038688793778419495,
-0.023422805592417717,
-0.039048850536346436,
0.09871713072061539,
-0.12935157120227814,
-0.08097562938928604,
-0.08026036620140076,
0.09477176517248154,
-0.016387617215514183,
0.016990656033158302,
-0.08228129148483276,
-0.013419480063021183,
0.09099746495485306,
-0.12665517628192902,
-0.11556627601385117,
-0.06357208639383316,
0.13796506822109222,
-0.03748014569282532,
-0.06792362779378891,
-0.11707259714603424,
-0.03880562260746956,
0.021529851481318474,
0.1335168182849884,
-0.20159269869327545,
-0.020768262445926666,
0.03235907480120659,
0.17776764929294586,
-0.13711069524288177,
0.054383035749197006,
0.1364498734474182,
-0.0664997398853302,
-0.13668900728225708,
-0.05714643374085426,
0.06318619847297668,
-0.04915833845734596,
-0.037615757435560226,
-0.030773334205150604,
0.16446112096309662,
-0.04886315017938614,
-0.18910305202007294,
0.07617077976465225,
-0.016795340925455093,
0.09917127341032028,
-0.018028702586889267,
0.17936013638973236,
0.1950056403875351,
-0.07366102188825607,
0.06003068387508392,
-0.06908491253852844,
0.010838094167411327,
-0.01070399209856987,
-0.02660319395363331,
0.013416670262813568,
-0.06685419380664825,
-0.02624829299747944,
-0.03683823347091675,
-0.09697310626506805,
-0.18608561158180237,
0.0381377749145031,
0.14146940410137177,
-0.1311713010072708,
0.07777606695890427,
-0.01577705889940262,
-0.17565688490867615,
0.03242841362953186,
0.033038247376680374,
-0.10881786793470383,
-0.11456996947526932,
-0.020494369789958,
0.029386846348643303,
0.09281162917613983,
0.1401824951171875,
0.15178707242012024,
0.040599074214696884,
0.09011775255203247,
-0.24185405671596527,
-0.048800211399793625,
0.0538560152053833,
0.024362187832593918,
0.08835064619779587,
-0.12078657001256943,
-0.029829923063516617,
-0.050800859928131104,
-0.027568737044930458,
0.11569537967443466,
-0.08833982795476913,
-0.07752125710248947,
0.04416066035628319,
0.10488185286521912,
-0.03403449431061745,
-0.036388035863637924,
-0.028469476848840714,
0.00013972366286907345,
-0.02620040997862816,
0.019505295902490616,
0.03172631934285164,
-0.009704504162073135,
-0.008721652440726757,
0.02358195185661316,
-0.02107628993690014,
0.10953398793935776,
-0.12684720754623413,
-0.011352095752954483,
0.20320820808410645,
0.11569026112556458,
0.06384299695491791,
0.07973365485668182,
0.07756686955690384,
-0.014700566418468952,
-0.07601739466190338,
-0.15688274800777435,
0.043123140931129456,
-0.07327551394701004,
0.11937576532363892,
-0.16742980480194092,
-0.06767740845680237,
-0.032997481524944305,
0.03229013830423355,
-0.07201521098613739,
0.020497772842645645,
0.1007266715168953,
0.10656307637691498,
-0.006670929957181215,
0.045204728841781616,
-0.11228744685649872,
0.03726661205291748,
-0.09642747044563293,
-0.021383125334978104,
0.09304244816303253,
0.16754911839962006,
0.046043168753385544,
-0.06674063950777054,
0.05671413242816925,
-0.1691814512014389,
-0.09079419821500778,
0.02362711913883686,
-0.03823481500148773,
0.032727308571338654,
0.027651354670524597,
-0.06272287666797638,
0.25346511602401733,
-0.0711563304066658,
-0.09735190868377686,
0.09871630370616913,
-0.09277880936861038,
0.17078223824501038,
-0.04301628842949867,
-0.12943820655345917,
0.09328215569257736,
-0.03212863951921463,
0.07257618755102158,
-0.0919959545135498,
-0.09690722078084946,
-0.014983730390667915,
-0.02383156679570675,
0.1599690020084381,
0.2708745300769806,
0.004232767503708601,
0.06919010728597641,
-0.18598918616771698,
-0.18889376521110535,
0.12317569553852081,
0.20423759520053864,
-0.018112223595380783,
0.05860372632741928,
0.04035134240984917,
0.23361057043075562,
-0.036147184669971466,
0.09624502807855606,
0.15925373136997223,
-0.05318930000066757,
0.0999671220779419,
-0.1810319870710373,
-0.05631474032998085,
0.24686497449874878,
-0.29344862699508667,
-0.08175241202116013,
-0.1502540409564972,
0.03189156949520111,
-0.21783162653446198,
-0.0316685251891613,
0.0770697370171547,
0.011430091224610806,
-0.20418010652065277,
0.12323997914791107,
-0.05420595780014992,
-0.06644335389137268,
0.017708318307995796,
-0.031245650723576546,
-0.069255530834198,
0.029646968469023705,
-0.010673110373318195,
-0.043574053794145584,
0.04528564214706421,
-0.010181069374084473,
0.17210781574249268,
-0.11144612729549408,
-0.03275112062692642,
-0.01416890136897564,
-0.11918938905000687,
0.16780740022659302,
-0.04347151517868042,
-0.07990653067827225,
-0.1383093297481537,
-0.07701651751995087,
0.13612787425518036,
0.06718118488788605,
-0.03026001900434494,
-0.10584010183811188,
0.1504666954278946,
0.04537953436374664,
-0.04277321323752403,
-0.07999415695667267,
-0.05302651226520538,
0.06232829764485359,
-0.06967832148075104,
0.006939463783055544,
0.03764990344643593,
-0.16889509558677673,
-0.0128104779869318,
-0.12893931567668915,
0.004090023227035999,
-0.10927903652191162,
0.02363210916519165,
-0.0021094942931085825,
0.09061166644096375,
-0.15584534406661987,
0.10387682914733887,
-0.05615909397602081,
-0.08126594126224518,
-0.12864066660404205,
-0.10040390491485596,
0.049997348338365555,
-0.06948837637901306,
-0.2262738049030304,
0.07372745871543884,
-0.0751219317317009,
-0.023589715361595154,
0.0006566792726516724,
0.015917714685201645,
0.015185697935521603,
0.1439286172389984,
-0.048737782984972,
0.04775804653763771,
-0.03251831233501434,
-0.08096536993980408,
0.11022157967090607,
0.08137879520654678,
0.06090184673666954,
-0.00013641569239553064,
-0.08019585907459259,
0.029292188584804535,
0.0633009821176529,
-0.12884356081485748,
0.08761142194271088,
0.026820791885256767,
-0.08458266407251358,
0.07295160740613937,
0.15415427088737488,
-0.0795522928237915,
0.11442394554615021,
0.02001115493476391,
0.09106463938951492,
-0.016615290194749832,
-0.21292705833911896,
0.10298934578895569,
0.05502275377511978,
0.0073677487671375275,
-0.2833021283149719,
0.02874218113720417,
-0.11885728687047958,
0.14102113246917725,
0.07653405517339706,
0.09427811205387115,
-0.18969523906707764,
0.029876410961151123,
0.09227520227432251,
-0.013809707947075367,
-0.19043710827827454,
0.2721906006336212,
-0.09463087469339371,
0.16874489188194275,
-0.0929885283112526,
-0.20977464318275452,
0.11410222947597504,
-0.24532605707645416,
0.1033991351723671,
-0.10767566412687302,
0.1346479207277298,
0.04692460969090462,
-0.06546223908662796,
-0.06456930190324783,
-0.016968602314591408,
-0.17973142862319946,
0.006486006546765566,
0.12100864946842194,
0.16770276427268982,
0.09269894659519196,
-0.02782367542386055,
0.08303628861904144,
-0.01005392987281084,
0.12554210424423218,
-0.0039508226327598095,
0.06577645242214203,
-0.16509583592414856,
0.04058369994163513,
-0.1464710533618927,
0.06944134086370468,
0.004074519500136375,
0.030400428920984268,
-0.23784418404102325,
-0.16445674002170563,
0.17691773176193237,
-0.04592552036046982,
-0.12712617218494415,
-0.0823761522769928,
0.09494348615407944,
0.1738746613264084,
0.09308170527219772,
-0.06952536106109619,
-0.018745578825473785,
0.057547252625226974,
0.07872483134269714,
0.09157146513462067,
0.04403744265437126,
0.016956856474280357,
-0.09269630163908005,
-0.029361916705965996,
-0.06743098795413971,
-0.28720706701278687,
0.07613074034452438,
0.005947081837803125,
-0.04800977557897568,
0.05805841088294983,
-0.22678130865097046,
0.00736323744058609,
-0.036018453538417816,
-0.09721697121858597,
0.21445755660533905,
0.14375033974647522,
-0.037552669644355774,
0.07481253147125244,
0.047465730458498,
0.12795665860176086,
0.0499894879758358,
0.3371717631816864,
0.1206621453166008,
0.04664211347699165,
0.07534867525100708,
0.11638755351305008,
-0.1137082502245903,
-0.01809467002749443,
0.027630813419818878,
-0.07026474177837372,
0.10068340599536896,
-0.033441174775362015,
-0.02745586819946766,
-0.09059090167284012,
-0.016674429178237915,
-0.09251946210861206,
-0.1066908910870552,
-0.14217059314250946,
-0.0029501612298190594,
-0.10616209357976913,
-0.12213589251041412,
0.23970355093479156,
-0.06059916317462921,
0.09325772523880005,
-0.027130169793963432,
0.08298519998788834,
-0.11706145107746124,
-0.025369465351104736,
0.02586756832897663,
-0.10644304752349854,
0.07422038167715073,
0.011267676949501038,
0.040812499821186066,
0.11823710054159164,
-0.12311052531003952,
0.036918528378009796,
-0.09282504767179489,
-0.07867162674665451,
0.09925122559070587,
0.00831183698028326,
0.07572954893112183,
0.18012267351150513,
-0.11015387624502182,
0.25394564867019653,
0.0647750273346901,
-0.010540131479501724,
-0.14140892028808594,
0.09216330945491791,
0.14021435379981995,
-0.07399103045463562,
0.030010830610990524,
-0.0632258877158165,
0.026569640263915062,
-0.31273141503334045,
0.09507186710834503,
0.048706747591495514,
0.03564697876572609,
0.0877167135477066,
0.044927213340997696,
0.0967792421579361,
-0.12211425602436066,
-0.1670200675725937,
0.09019871801137924,
0.036771178245544434,
-0.01080002449452877,
0.07695483416318893,
0.17063258588314056,
0.04803616926074028,
-0.10535462200641632,
0.06133848801255226,
0.10331029444932938,
-0.0652971938252449,
0.12990865111351013,
0.06802456825971603,
0.031069843098521233,
-0.06295310705900192,
-0.0010956355836242437,
-0.042811691761016846,
0.05890437588095665,
-0.03734767809510231,
-0.0005172397359274328,
0.023220261558890343,
-0.13965068757534027,
-0.07897917926311493,
-0.0788731500506401,
0.023132644593715668,
0.04229813814163208,
0.0890314057469368,
-0.07917604595422745,
-0.03219835087656975,
0.1405557245016098,
-0.03651417791843414,
-0.04889789968729019,
0.03253275156021118,
-0.08247864246368408,
-0.03458242863416672,
-0.04264979436993599,
-0.04301273822784424,
-0.09590031951665878,
0.13572357594966888,
0.0012255808105692267,
0.16827429831027985,
0.0843420997262001,
-0.09352738410234451,
0.03125839680433273,
-0.28809845447540283,
0.08971253037452698,
-0.049394357949495316,
0.11219234764575958,
-0.16251173615455627
] | [
-0.6405137181282043,
-0.40237531065940857,
-0.4379032552242279,
0.4858168959617615,
0.026843443512916565,
0.8250871896743774,
0.591051459312439,
0.49869590997695923,
-0.05352409556508064,
-0.5380819439888,
-0.030063176527619362,
0.1934276521205902,
-0.17665459215641022,
-0.2884982228279114,
0.21587994694709778,
0.6314683556556702,
0.07805005460977554,
0.01826055534183979,
0.7228599190711975,
-0.17166107892990112,
0.09680569171905518,
-0.02651747688651085,
0.3800112009048462,
0.005414656829088926,
-0.27775484323501587,
-0.3200223743915558,
-0.5080534815788269,
-0.2075829803943634,
-0.3583580255508423,
0.2830114960670471,
-0.5827750563621521,
0.12257585674524307,
0.436928391456604,
0.3532000184059143,
0.564717710018158,
0.048827674239873886,
-0.07594364136457443,
-0.12622830271720886,
0.053892455995082855,
0.07402795553207397,
-0.5602610111236572,
0.11546620726585388,
0.21992602944374084,
0.2670930027961731,
0.18983040750026703,
-0.04674329236149788,
-1.2200636863708496,
0.3175443112850189,
-0.17276346683502197,
-0.8183501362800598,
-0.5250676274299622,
-0.19748036563396454,
0.3238544166088104,
0.5963900089263916,
0.11509183794260025,
-0.107943594455719,
0.35183751583099365,
0.2924298644065857,
-0.15422554314136505,
0.19241882860660553,
0.8530176877975464,
0.5063220262527466,
0.34927883744239807,
0.2658578157424927,
-0.23652294278144836,
0.05941621586680412,
0.42366692423820496,
0.050829172134399414,
-0.19484123587608337,
-0.711532711982727,
0.17822271585464478,
0.7535077333450317,
0.14014923572540283,
0.10093405097723007,
-0.3228948712348938,
0.20055116713047028,
-0.19007807970046997,
0.28901323676109314,
0.10063039511442184,
-0.03848069906234741,
-0.1955675482749939,
-0.8078544735908508,
0.04586132615804672,
-0.11808034032583237,
-0.24477964639663696,
-0.40330132842063904,
0.8196008801460266,
-0.13639597594738007,
-0.9123497605323792,
0.4288228750228882,
-0.7800590991973877,
0.031614482402801514,
0.29552367329597473,
0.5088914632797241,
0.5439472794532776,
-0.18054720759391785,
-0.21971161663532257,
-0.05083504319190979,
0.6170822978019714,
-0.712860107421875,
-0.5503864288330078,
-0.9498862028121948,
-0.5838750004768372,
-0.03559653460979462,
-0.6456656455993652,
0.021811138838529587,
-1.0994744300842285,
0.11977823823690414,
-0.3225787580013275,
0.3308296799659729,
-0.7427442669868469,
-0.19227683544158936,
0.3549487292766571,
0.19111023843288422,
-0.39548635482788086,
-0.023019053041934967,
-0.0343155562877655,
-0.17994794249534607,
-0.1811835765838623,
-0.1845594048500061,
-0.005594165064394474,
0.1260816603899002,
-0.17074158787727356,
0.2197311520576477,
-0.20783691108226776,
0.035901594907045364,
-0.366798460483551,
0.30805057287216187,
-0.12659867107868195,
0.17417366802692413,
-0.03723131865262985,
-0.23911958932876587,
-0.2008027583360672,
0.026582183316349983,
-0.21551357209682465,
-0.5486097931861877,
-0.21325384080410004,
0.052347972989082336,
-0.03783343732357025,
0.07125475257635117,
-0.13377344608306885,
0.008458757773041725,
0.27349352836608887,
-0.34788942337036133,
0.39084601402282715,
-0.6821686029434204,
-0.6143672466278076,
0.24633195996284485,
-0.7538977265357971,
0.05913751944899559,
0.25489965081214905,
0.35555312037467957,
-0.1638355553150177,
0.3167976140975952,
0.3675808012485504,
0.3050578832626343,
0.007362578995525837,
-0.15388232469558716,
-0.3047502338886261,
-0.0821155235171318,
0.35859501361846924,
0.6810493469238281,
0.2259669452905655,
-0.08428235352039337,
0.7316536903381348,
-0.22368060052394867,
-0.6080368161201477,
0.48941099643707275,
-0.19647999107837677,
0.2771236002445221,
-0.5139791965484619,
-0.662840723991394,
0.27492234110832214,
-0.1847514808177948,
-0.250088095664978,
0.48996007442474365,
0.2121702879667282,
0.3231496810913086,
0.4580309987068176,
-0.3447554409503937,
-0.23925529420375824,
0.034911416471004486,
-0.20812639594078064,
0.06909839808940887,
0.10304594039916992,
-0.3709271252155304,
0.7266157865524292,
-0.01675555296242237,
0.24747776985168457,
-0.05028047785162926,
-0.44722867012023926,
0.11035291850566864,
0.42860254645347595,
0.007925187237560749,
0.03177899494767189,
-0.14207139611244202,
0.025058120489120483,
-0.006179651711136103,
-0.5869449973106384,
-0.5620450377464294,
-0.08105451613664627,
-0.01896088942885399,
0.08508529514074326,
-0.06164143607020378,
-0.6453149318695068,
0.2898566424846649,
-0.19194786250591278,
-0.8347829580307007,
-0.17305921018123627,
0.16413678228855133,
-0.01736634038388729,
0.29173094034194946,
-0.31920695304870605,
0.2484014332294464,
0.03193426504731178,
-0.05750153586268425,
-0.5523152947425842,
-0.37817129492759705,
-0.031182529404759407,
0.010498217307031155,
0.6141337156295776,
0.005562508013099432,
0.5754885673522949,
0.09742695093154907,
0.24905730783939362,
0.595888614654541,
0.3569446802139282,
-0.04178495332598686,
0.2616642415523529,
-0.33417198061943054,
-0.44338324666023254,
-0.18796509504318237,
-0.07724089920520782,
0.09030621498823166,
-0.18053226172924042,
-0.038269173353910446,
0.2791324555873871,
-0.3814674913883209,
0.440965473651886,
-0.4539218246936798,
-0.437311589717865,
0.27674201130867004,
-0.39244967699050903,
0.32035577297210693,
-0.34466156363487244,
0.2573222815990448,
0.030993448570370674,
0.2983739972114563,
-0.009839211590588093,
-0.38673514127731323,
0.11693607270717621,
-0.066309355199337,
-0.4121782183647156,
-0.1592489331960678,
0.7279937863349915,
-0.3668922781944275,
-0.6626343131065369,
-0.6304081082344055,
0.43349120020866394,
0.1777256727218628,
-0.11462395638227463,
0.4747953712940216,
0.04924236983060837,
-0.6568655371665955,
0.10712870955467224,
-0.2694474160671234,
-1.0508304834365845,
-1.1156034469604492,
0.39187684655189514,
-0.21080021560192108,
0.3013175129890442,
-0.02215932123363018,
-0.2811366319656372,
-0.37139707803726196,
-0.48152124881744385,
0.3146005868911743,
-0.023905877023935318,
0.2040567845106125,
-0.2825774848461151,
-0.6946139335632324,
0.10420634597539902,
0.7348901629447937,
-0.4308755397796631,
-0.3500937521457672,
-0.7078908085823059,
0.032581526786088943,
-0.06528077274560928,
-0.14389154314994812,
0.4443519115447998,
-0.3639358878135681,
-0.5161067247390747,
0.380062073469162,
0.3595781922340393,
0.2841747999191284,
-0.1788645088672638,
-0.1404784470796585,
-0.35559791326522827,
0.7628968358039856,
0.7743830680847168,
-0.26581716537475586,
0.2301884889602661,
0.248964324593544,
0.04240370914340019,
0.33601459860801697,
0.686220645904541,
-0.11663446575403214,
0.05191066861152649,
0.05023445561528206,
-5.926717758178711,
0.15985824167728424,
0.41227540373802185,
0.03696600720286369,
-0.06717564165592194,
-0.685660183429718,
-0.4523402154445648,
-0.00650072330608964,
0.6943573951721191,
-0.029640253633260727,
-0.2096613347530365,
-0.25302255153656006,
-0.2442178875207901,
0.3812408447265625,
0.215958833694458,
0.19777575135231018,
0.4026188850402832,
-0.5023983120918274,
0.30367109179496765,
0.43691158294677734,
0.02853456512093544,
0.1861387938261032,
-0.08519032597541809,
0.40896081924438477,
-0.1732265204191208,
0.446936696767807,
-0.3138706386089325,
0.4826297461986542,
-0.7074016332626343,
-0.14766176044940948,
-0.5846761465072632,
-0.09030564874410629,
-0.591183602809906,
-0.501499593257904,
-0.005868382286280394,
0.3856718838214874,
-0.028344735503196716,
-0.19734036922454834,
0.5262187719345093,
0.26671701669692993,
-0.3591674566268921,
0.4326573610305786,
-0.2670843005180359,
0.5088358521461487,
0.3468944728374481,
0.278751939535141,
0.9903849363327026,
0.050294771790504456,
-0.24699676036834717,
0.21231505274772644,
0.2671973407268524,
0.200454980134964,
0.8399147987365723,
-0.1555546373128891,
0.14770430326461792,
0.22617369890213013,
-0.34804847836494446,
-0.7687944769859314,
0.28784874081611633,
-0.1287899911403656,
-0.20163242518901825,
-0.1705934703350067,
0.31160253286361694,
0.3891797363758087,
-0.6762845516204834,
-0.03927423804998398,
-0.24367013573646545,
0.7660377025604248,
0.6083751916885376,
-0.11142442375421524,
0.4186219871044159,
0.13385175168514252,
-0.10049636662006378,
-0.7557066679000854,
-0.07680846005678177,
-0.09487045556306839,
-0.030416471883654594,
-0.056824762374162674,
-0.49155884981155396,
-0.19291633367538452,
-0.1154153123497963,
-0.0441974475979805,
0.0636155754327774,
0.12494843453168869,
0.5879583358764648,
-0.5662126541137695,
0.04872671514749527,
0.01690656691789627,
-0.14738738536834717,
0.15299998223781586,
-0.4060676395893097,
-1.2508771419525146,
0.4381316006183624,
-0.48191437125205994,
0.8022720813751221,
0.5865172743797302,
-0.029726622626185417,
0.0035025940742343664,
0.30741146206855774,
-0.19067350029945374,
0.10247617214918137,
0.15762104094028473,
-0.29479309916496277,
0.2469588965177536,
-0.14295031130313873,
0.6153372526168823,
-0.2612922787666321,
0.410405695438385,
0.3434380888938904,
-0.9637153744697571,
0.37005409598350525,
0.8671360015869141,
-0.07724590599536896,
0.5419739484786987,
-0.22870415449142456,
-0.195687398314476,
-0.13765989243984222,
-0.11901091784238815,
-0.3170420229434967,
-0.813113808631897,
-0.09001196175813675,
0.2522040605545044,
-0.1321377009153366,
-0.44381189346313477,
-0.1272321492433548,
0.337159663438797,
-0.034877993166446686,
-0.18754339218139648,
0.10602138191461563,
0.9518159627914429,
0.4172194004058838,
0.08056331425905228,
0.23670290410518646,
-0.26023632287979126,
0.598850429058075,
0.0900973454117775,
0.13066397607326508,
-0.677077054977417,
-0.3661991357803345,
0.04574254900217056,
0.3012562394142151,
0.02984621934592724,
-0.04079459235072136,
-0.1463468372821808,
0.3255300521850586,
-0.3803701400756836,
0.16178934276103973,
-0.2730391025543213,
-0.1169378012418747,
-0.32213449478149414,
-0.026793222874403,
-0.11395637691020966,
0.5738397836685181,
-0.14538982510566711,
-0.12061220407485962,
-0.4149736762046814,
-0.04234865680336952,
-0.3475729525089264,
-0.343759149312973,
-0.43574774265289307,
0.4395364224910736,
-0.5820834040641785,
-0.03472289443016052,
0.03676805645227432,
0.13348166644573212,
-0.3336793780326843,
-0.10264715552330017,
0.0874810665845871,
0.27708879113197327,
-0.2545282542705536,
-0.018138179555535316,
-0.6050015687942505,
0.09920167922973633,
0.16164147853851318,
0.14675846695899963,
0.012121990323066711,
-0.3198172152042389,
0.01902514323592186,
-0.26108139753341675,
0.07013783603906631,
-0.22209352254867554,
-0.2217928171157837,
-0.3744063675403595,
0.4201135039329529,
-0.04484299197793007,
0.3405519723892212,
-0.7450613975524902,
0.024716639891266823,
0.45330923795700073,
0.6937953233718872,
0.0752611756324768,
-0.832017183303833,
-0.045036546885967255,
0.5537779331207275,
-0.18164633214473724,
-0.35486695170402527,
0.25607869029045105,
-0.2295973151922226,
-0.02589963562786579,
-0.12025386095046997,
0.1403854638338089,
-0.2387540489435196,
-0.2451774626970291,
0.13782870769500732,
-0.5679054260253906,
-0.41225868463516235,
0.4581570625305176,
-0.20775218307971954,
-0.23662292957305908,
0.04961321875452995,
-0.18901465833187103,
-0.6870233416557312,
-0.5773178935050964,
0.18307825922966003,
-0.2945728302001953,
-0.38617920875549316,
-0.22496278584003448,
0.015849879011511803,
-0.268669992685318,
-0.2749374806880951,
0.03696984052658081,
-0.8148856163024902,
-0.38810479640960693,
-0.025172395631670952,
-0.1502196341753006,
0.04896705970168114,
0.22394172847270966,
-0.05397177115082741,
0.2469419240951538,
-0.03264225274324417,
-0.42337819933891296,
1.041951298713684,
-0.23077920079231262,
0.5565585494041443,
-0.31003889441490173,
0.608592689037323,
-0.7702485918998718,
0.08621510863304138,
-0.6096031665802002,
-0.02853826992213726,
0.29969823360443115,
0.2085707187652588,
-0.4000083804130554,
0.6077346205711365,
-0.518153965473175,
0.34654539823532104,
0.28409817814826965,
-0.6033403873443604,
-0.05450035631656647,
0.4529287815093994,
-0.6848151683807373,
0.0723842903971672,
0.20467908680438995,
-0.10367891937494278,
0.44089752435684204,
-0.36706554889678955,
0.18545079231262207,
-0.10165735334157944,
0.12503987550735474,
-0.046692509204149246,
-0.07009854167699814,
0.18909285962581635,
0.35962802171707153,
0.08282849192619324,
0.04460080713033676,
0.0568276047706604,
0.6421523094177246,
0.2641369700431824,
0.06410586833953857,
0.27596914768218994,
0.29972729086875916,
-0.7036498188972473,
-0.16414666175842285,
0.033663712441921234,
0.07351209223270416,
0.20434892177581787,
-0.46359142661094666,
-0.5439566373825073,
-0.9238333106040955,
0.7518335580825806,
-0.23520536720752716,
0.1129995658993721,
-0.23092907667160034,
0.11087613552808762,
-0.09935221821069717,
-0.9354085326194763,
0.16645683348178864,
0.17975454032421112,
-0.5378636717796326,
-0.5492104291915894,
0.41337937116622925,
0.5800880789756775,
0.10638631135225296,
-0.33817175030708313,
0.5746670961380005,
-0.022355975583195686,
-0.2026936411857605,
0.31927573680877686,
0.40780094265937805,
-0.05101113021373749,
-0.13658465445041656,
-0.8546320796012878,
-0.2016657441854477,
0.03351324796676636,
-0.1771748811006546,
-0.37395960092544556,
-0.03345078229904175,
-0.6526021361351013,
0.12836319208145142,
0.1983776092529297,
0.6344493627548218,
-0.4830472469329834,
0.00027233120636083186,
0.5377674102783203,
0.24042531847953796,
-0.018643002957105637,
0.20486709475517273,
-0.12828630208969116,
0.4258779287338257,
0.036379870027303696,
-0.12309711426496506,
0.968438446521759,
0.34873682260513306,
-0.10962457954883575,
-0.2355499267578125,
0.5139114856719971,
0.04202704504132271,
0.39189770817756653,
-0.1655423492193222,
0.05406373739242554,
0.7246348261833191,
0.09051239490509033,
0.22606003284454346,
0.4750409722328186,
-0.2502919137477875,
-0.41616392135620117,
0.3024485409259796,
-0.09973996132612228,
0.31970423460006714,
0.7033059597015381,
-0.14586137235164642,
-0.6549742221832275,
0.41837021708488464,
0.5309693217277527,
-0.09886568039655685,
0.3642052412033081,
0.17431573569774628,
0.18348105251789093,
-0.7551875710487366,
0.7793015241622925,
0.3865963816642761,
0.42172300815582275,
0.010295970365405083,
0.6963356733322144,
-0.21687792241573334,
-0.13037286698818207,
0.6820765137672424,
-0.027327176183462143,
-0.17987865209579468,
-0.07623502612113953,
0.5820028185844421,
0.35144758224487305,
0.09853458404541016,
-0.41020703315734863,
-1.1194757223129272,
0.6177181005477905,
0.2997124493122101,
-0.031544096767902374,
-0.06057187542319298,
-0.3863482177257538,
-0.5932437181472778,
-0.016541818156838417,
-0.17606118321418762,
0.8261231780052185,
0.457338809967041,
0.6508395075798035,
-0.0012006243923678994,
0.5394740104675293,
0.15253518521785736,
0.1912892609834671,
-0.43653446435928345,
0.17960892617702484,
-0.6596009135246277,
-0.2381877303123474,
0.01935752108693123,
-0.3261159658432007,
-0.1887521892786026,
0.29278498888015747,
0.3507181704044342,
0.19733290374279022,
-0.1805429607629776,
0.6191128492355347,
0.22348980605602264,
0.17281083762645721,
-0.2651877999305725,
-0.0181918703019619,
0.0824960470199585,
0.4466002881526947,
-0.030238976702094078,
0.28071486949920654,
0.23278141021728516,
0.2960681915283203,
0.18854571878910065,
0.32386285066604614,
-0.22935795783996582,
0.16373533010482788,
-0.31030547618865967,
0.3944079577922821,
-0.10205652564764023,
-0.27200567722320557,
0.2351718693971634,
0.1578563153743744,
-0.4197356700897217,
0.30079665780067444,
0.5369536876678467,
-0.018321508541703224,
-0.19461378455162048,
-0.057749275118112564,
0.5191723704338074,
-0.5366772413253784,
-0.2823029160499573,
-0.30010727047920227,
0.48116350173950195,
0.5730797052383423,
0.4100930392742157,
0.7864708304405212,
-0.25818997621536255,
0.06303063780069351,
-0.14138896763324738,
0.10440759360790253,
-0.022119775414466858,
-0.05415227636694908,
-0.4690716862678528,
-0.0709342360496521,
-0.22036102414131165,
-0.42220842838287354,
0.48474106192588806,
-0.46471768617630005,
0.4343828856945038,
-0.17350706458091736,
-0.04658008739352226,
0.04700089618563652,
0.530000627040863,
-0.028570136055350304,
0.434516042470932,
-0.6207054853439331,
0.6326807737350464,
0.35986989736557007,
-0.19263778626918793,
0.8151133060455322,
-0.0821625366806984,
-0.09531925618648529,
0.04366768151521683,
-0.11371362954378128,
0.5795555710792542,
-0.13917334377765656,
-0.04046087712049484,
-0.2095411717891693,
0.17678895592689514,
0.14281535148620605
] |
|
BACKGROUND: Since late April, 2009, a novel influenza virus A (H1N1), generally referred to as the “swine flu,” has spread around the globe and infected hundreds of thousands of people. During the first few days after the initial outbreak in Mexico, extensive media coverage together with a high degree of uncertainty about the transmissibility and mortality rate associated with the virus caused widespread concern in the population. The spread of an infectious disease can be strongly influenced by behavioral changes (e.g., social distancing) during the early phase of an epidemic, but data on risk perception and behavioral response to a novel virus is usually collected with a substantial delay or after an epidemic has run its course. METHODOLOGY/PRINCIPAL FINDINGS: Here, we report the results from an online survey that gathered data (n = 6,249) about risk perception of the Influenza A(H1N1) outbreak during the first few days of widespread media coverage (April 28 - May 5, 2009). We find that after an initially high level of concern, levels of anxiety waned along with the perception of the virus as an immediate threat. Overall, our data provide evidence that emotional status mediates behavioral response. Intriguingly, principal component analysis revealed strong clustering of anxiety about swine flu, bird flu and terrorism. All three of these threats receive a great deal of media attention and their fundamental uncertainty is likely to generate an inordinate amount of fear vis-a-vis their actual threat. CONCLUSIONS/SIGNIFICANCE: Our results suggest that respondents' behavior varies in predictable ways. Of particular interest, we find that affective variables, such as self-reported anxiety over the epidemic, mediate the likelihood that respondents will engage in protective behavior. Understanding how protective behavior such as social distancing varies and the specific factors that mediate it may help with the design of epidemic control strategies. | [
-0.017610929906368256,
0.015726476907730103,
-0.002236824482679367,
0.0044748131185770035,
0.01150001585483551,
0.004827599506825209,
0.005897582042962313,
0.018537499010562897,
-0.010717015713453293,
-0.036574460566043854,
0.00551830418407917,
0.016099968925118446,
-0.0038777287118136883,
0.0069455043412745,
0.01880696788430214,
-0.014561198651790619,
0.006314965430647135,
0.01993933506309986,
0.011797716841101646,
-0.009421286173164845,
-0.018993834033608437,
0.0012915055267512798,
0.008894624188542366,
0.025806624442338943,
0.018013907596468925,
-0.0037295809015631676,
0.017365727573633194,
-0.004015995189547539,
-0.013064411468803883,
-0.005086516961455345,
0.0017928204033523798,
0.03125099092721939,
0.0001346454955637455,
-0.006367020308971405,
0.00854504108428955,
0.016323396936058998,
0.0020249681547284126,
0.020460769534111023,
-0.016329549252986908,
-0.0005393160972744226,
0.02670762687921524,
-0.013963848352432251,
0.003613618668168783,
0.0014090226031839848,
-0.0034823939204216003,
0.034673646092414856,
-0.008075429126620293,
-0.00907047651708126,
-0.011223501525819302,
0.004126307554543018,
-0.0055305613204836845,
-0.0019146250560879707,
-0.0038863338995724916,
0.019466914236545563,
-0.005371718667447567,
0.007952103391289711,
0.017188236117362976,
0.007344513665884733,
-0.018342167139053345,
0.03630797192454338,
0.0041825054213404655,
0.010515481233596802,
0.0031901404727250338,
-0.0074282800778746605,
-0.0013624129351228476,
-0.06785443425178528,
-0.019086597487330437,
0.0036848895251750946,
0.0038692131638526917,
0.020346198230981827,
0.006447992753237486,
0.0019564093090593815,
0.016968078911304474,
-0.03347279131412506,
-0.009473858401179314,
-0.008850041776895523,
0.00895556341856718,
0.03814265877008438,
-0.013355856761336327,
0.009374262765049934,
0.021375365555286407,
0.02344748191535473,
0.011552623473107815,
0.014163573272526264,
0.004179270938038826,
-0.004730585962533951,
-0.01910535991191864,
-0.006464566104114056,
-0.012679755687713623,
0.01383606344461441,
0.006363807246088982,
-0.014469972811639309,
-0.02634638361632824,
-0.013778784312307835,
-0.006814679130911827,
-0.03373104706406593,
-0.006461184471845627,
-0.014192888513207436,
-0.027434274554252625,
-0.019272634759545326,
0.0013241756241768599,
0.011580945923924446,
0.012924490496516228,
0.016179967671632767,
0.004177454859018326,
0.005319095216691494,
-0.013803132809698582,
0.00023859133943915367,
-0.003004348836839199,
-0.0025304178707301617,
0.0006080418825149536,
-0.009857742115855217,
0.00533872377127409,
0.008350910618901253,
-0.013915950432419777,
0.004514422733336687,
0.00301259383559227,
0.028140919283032417,
-0.003231136128306389,
0.009749380871653557,
-0.012814728543162346,
-0.009049590677022934,
0.007882792502641678,
-0.006225562654435635,
-0.0014417232014238834,
-0.007130444049835205,
-0.014380574226379395,
-0.002585938898846507,
-0.0051466356962919235,
-0.004308253526687622,
-0.0026535303331911564,
-0.003121062181890011,
-0.03411377966403961,
-0.0067335572093725204,
-0.015594729222357273,
-0.0022315746173262596,
-0.00655744131654501,
0.003020043484866619,
-0.003648869227617979,
-0.0021773744374513626,
-0.025742804631590843,
0.0064857532270252705,
-0.0018969824304804206,
0.011599907651543617,
0.012436781078577042,
-0.003139699809253216,
-0.012240491807460785,
0.016222527250647545,
0.012980454601347446,
0.01039782166481018,
-0.002450919011607766,
-0.00484214024618268,
-0.003268555039539933,
-0.008876126259565353,
-0.008752215653657913,
0.012046278454363346,
0.007046003360301256,
-0.026290344074368477,
-0.008490756154060364,
0.023717444390058517,
0.008364841341972351,
0.004343549720942974,
-0.013484861701726913,
0.006043720990419388,
0.013613610528409481,
-0.011706916615366936,
0.021259307861328125,
-0.010583426803350449,
-0.001303178956732154,
0.005036973860114813,
-0.003002698067575693,
0.018247682601213455,
-0.00991914514452219,
0.01202093530446291,
0.00492355041205883,
-0.005339385010302067,
0.01907077245414257,
0.004563912749290466,
0.01052981149405241,
0.06678052991628647,
-0.007639443501830101,
-0.02962396666407585,
-0.0012645252281799912,
0.010521377436816692,
-0.003913844004273415,
0.0003672426100820303,
0.01760294660925865,
-0.009227828122675419,
-0.004706131760030985,
-0.012308156117796898,
-0.010134551674127579,
-0.005670529790222645,
-0.006048787385225296,
-0.026914864778518677,
0.0006092678522691131,
0.0046965256333351135,
0.02757314220070839,
-0.0027081877924501896,
-0.0058982945047318935,
0.01421663910150528,
-0.0018117306753993034,
-0.007662988267838955,
0.02728061005473137,
0.016383850947022438,
-0.009175432845950127,
0.008388444781303406,
0.01575537770986557,
-0.0048853144980967045,
0.02043512836098671,
-0.01777108572423458,
0.00008591316873207688,
-0.00288952374830842,
0.007771166041493416,
-0.00282398983836174,
-0.004809333942830563,
-0.004694574978202581,
0.023882433772087097,
0.019627053290605545,
0.0008087828755378723,
-0.014290479943156242,
-0.0008006629650481045,
0.013690408319234848,
-0.03440345078706741,
0.012613354250788689,
0.021316275000572205,
0.0022888516541570425,
0.004556557163596153,
0.004010227508842945,
0.0056080021895468235,
0.00031124288216233253,
-0.011364491656422615,
0.015034517273306847,
-0.0024411575868725777,
-0.004119573161005974,
0.007336595095694065,
-0.004267365671694279,
0.005550445057451725,
-0.0023269038647413254,
0.002294512465596199,
-0.007114944979548454,
0.000925116240978241,
-0.014805348590016365,
0.00277845561504364,
-0.0010116079356521368,
0.004219112452119589,
-0.0036374025512486696,
0.011222939938306808,
-0.004747585393488407,
-0.022442655637860298,
0.002984129125252366,
0.008198834024369717,
0.0034472299739718437,
0.015938088297843933,
0.004384585656225681,
0.007610243745148182,
0.004231343511492014,
0.0008172891102731228,
-0.011436257511377335,
0.024834640324115753,
0.0015351851470768452,
0.007725391071289778,
0.00503627210855484,
-0.0043679699301719666,
-0.011518729850649834,
0.008323044516146183,
0.033484749495983124,
0.00037326570600271225,
0.0013838899321854115,
0.010629937052726746,
0.024980684742331505,
0.0009373110951855779,
-0.00712902657687664,
0.001133242272771895,
-0.08250073343515396,
-0.008254855871200562,
0.009341453202068806,
-0.006000567227602005,
0.010848546400666237,
-0.0006281828973442316,
0.012153267860412598,
-0.021719101816415787,
-0.009805018082261086,
0.035510968416929245,
0.006472702603787184,
0.01359033677726984,
0.0029672817327082157,
-0.018691783770918846,
0.0051580145955085754,
0.0008414830663241446,
0.005883866921067238,
0.007494265213608742,
-0.0014777788892388344,
-0.001671576639637351,
0.0011278953170403838,
-0.003967437893152237,
0.007092063780874014,
-0.013089196756482124,
-0.00022873282432556152,
-0.023669319227337837,
0.013532177545130253,
0.0015398277901113033,
0.0025443024933338165,
0.007523890119045973,
-0.0006516962312161922,
-0.009424477815628052,
-0.006424466613680124,
-0.024263115599751472,
0.010599968023598194,
-0.009563921019434929,
0.002611355157569051,
0.0015957799041643739,
-0.01074356958270073,
-0.012364231050014496,
0.008896568790078163,
0.007107727229595184,
-0.00399996992200613,
-0.0013586445711553097,
0.007735780440270901,
-0.016059085726737976,
0.005269983783364296,
0.004471819847822189,
0.01198076643049717,
0.010675756260752678,
-0.01586201973259449,
-0.007059129420667887,
0.018625842407345772,
0.005688759498298168,
-0.008931050077080727,
-0.006096764001995325,
0.0018134338315576315,
-0.004097450524568558,
-0.011435948312282562,
0.00017220026347786188,
-0.0239645317196846,
0.016975942999124527,
-0.018266983330249786,
-0.01311749778687954,
-0.030670173466205597,
-0.012447185814380646,
0.014721142128109932,
-0.006436813622713089,
-0.011489739641547203,
0.008785499259829521,
-0.012944743037223816,
-0.0009633592562749982,
-0.0018525917548686266,
-0.008202830329537392,
-0.0004042865475639701,
0.002713994588702917,
-0.00828922912478447,
-0.006341392640024424,
-0.00845759641379118,
-0.009158026427030563,
-0.010539736598730087,
0.0049117556773126125,
-0.004001910798251629,
0.0010856115259230137,
0.000916867284104228,
-0.002456227783113718,
0.013106901198625565,
-0.0030911886133253574,
0.012844177894294262,
-0.01687520183622837,
0.013503408059477806,
0.010351575911045074,
-0.015979919582605362,
0.007498574908822775,
-0.029381820932030678,
-0.012276285327970982,
-0.001813588896766305,
0.0089207012206316,
-0.00394769012928009,
0.007125004194676876,
0.00716693140566349,
-0.009072978049516678,
0.0063466415740549564,
-0.006838237401098013,
-0.011648783460259438,
0.014243870973587036,
0.006489356514066458,
-0.027542006224393845,
-0.011691134423017502,
-0.007783043198287487,
0.00873600598424673,
0.01580480858683586,
0.0023142388090491295,
-0.0023313197307288647,
0.010015484876930714,
0.008943121880292892,
0.015198511071503162,
-0.03134568780660629,
0.07262478023767471,
-0.010009389370679855,
0.004445848520845175,
-0.02102566696703434,
0.04461333528161049,
-0.029464546591043472,
-0.001265689847059548,
0.0027283586096018553,
-0.0008198237046599388,
-0.017213081941008568,
0.013041513040661812,
-0.04114425182342529,
-0.0062635065987706184,
-0.016904406249523163,
0.009485907852649689,
0.003409786382690072,
0.01678100973367691,
0.007880004122853279,
0.021647054702043533,
-0.0018018437549471855,
0.020432474091649055,
0.0008070238400250673,
-0.015440701507031918,
0.0026397057808935642,
0.009789954870939255,
0.012924735434353352,
0.03233088180422783,
-0.014436746016144753,
0.004576029721647501,
-0.000458782771602273,
0.011696835979819298,
-0.016771605238318443,
-0.0014275276334956288,
0.004413587972521782,
-0.0027755508199334145,
-0.011797054670751095,
-0.004019591491669416,
-0.0006901724264025688,
0.000276683596894145,
-0.010434589348733425,
-0.006073527503758669,
-0.010821061208844185,
-0.02230103127658367,
0.0170931126922369,
-0.019100025296211243,
0.018313109874725342,
-0.0071575939655303955,
-0.0014945096336305141,
-0.01037662848830223,
0.006308559328317642,
0.005090461578220129,
0.004953416995704174,
0.00576618080958724,
0.013234254904091358,
-0.016462303698062897,
0.02504761517047882,
-0.011913470923900604,
0.0036928565241396427,
0.01853659376502037,
0.0023241823073476553,
0.005142985377460718,
-0.011179223656654358,
-0.01651652902364731,
-0.0096446443349123,
-0.0021894224919378757,
0.0002690381952561438,
-0.00977013073861599,
0.014806563034653664,
-0.02103474549949169,
0.0070216115564107895,
0.0062138596549630165,
-0.019055813550949097,
-0.009503698907792568,
-0.014426317997276783,
-0.028781188651919365,
-0.009526913985610008,
-0.01973767951130867,
0.004303255118429661,
-0.01247655600309372,
0.0112145459279418,
-0.006568492390215397,
-0.024464711546897888,
-0.007446436211466789,
-0.0018830164335668087,
-0.00556317251175642,
-0.0017159197013825178,
-0.01543053425848484,
-0.07549221813678741,
-0.009458408690989017,
0.011921510100364685,
-0.005389287602156401,
0.020957427099347115,
-0.0099780960008502,
-0.010104838758707047,
0.00705401785671711,
-0.011458237655460835,
-0.005051850341260433,
-0.023987602442502975,
-0.0022918381728231907,
0.003094274550676346,
-0.009138536639511585,
0.016012035310268402,
0.005494489334523678,
-0.00999358855187893,
0.011659372597932816,
-0.008215120993554592,
0.008977010846138,
0.010396286845207214,
0.006649540271610022,
-0.0438813790678978,
0.0006848343182355165,
0.0028169401921331882,
-0.08180010318756104,
-0.010727295652031898,
0.014161801896989346,
-0.017755698412656784,
0.010635359212756157,
-0.01963450200855732,
-0.006492300890386105,
-0.035185396671295166,
-0.003936944529414177,
-0.013917583972215652,
0.001997919287532568,
-0.0039696237072348595,
0.003989433404058218,
0.0031833183020353317,
0.006043772213160992,
-0.0069821858778595924,
0.008032968267798424,
0.00474905502051115,
0.015611059963703156,
0.012332407757639885,
0.031075727194547653,
0.011152772232890129,
-0.008122749626636505,
0.001921503571793437,
-0.008789153769612312,
-0.003350089769810438,
0.007428600452840328,
0.0007318375282920897,
0.01765657216310501,
0.014345499686896801,
-0.01182037778198719,
-0.001905215671285987,
0.002734212204813957,
0.014653755351901054,
0.03591155633330345,
-0.00023080670507624745,
0.011847065761685371,
-0.0037699760869145393,
0.033465541899204254,
0.008435491472482681,
-0.007432224694639444,
0.017473194748163223,
-0.009701956994831562,
-0.000509417150169611,
0.006599368527531624,
-0.009030144661664963,
0.007690751925110817,
-0.004447107203304768,
0.016679104417562485,
-0.015713434666395187,
-0.000705770798958838,
-0.021102696657180786,
0.017214994877576828,
-0.008156262338161469,
-0.007965493947267532,
-0.0047613102942705154,
-0.0007084452081471682,
0.005298485979437828,
0.015322098508477211,
0.012654255144298077,
-0.004631098359823227,
0.003455699421465397,
0.0040526860393583775,
0.07165821641683578,
-0.019762717187404633,
0.007676598150283098,
-0.006311428267508745,
-0.008342425338923931,
0.0006143867503851652,
-0.002991665853187442,
0.02717599831521511,
-0.008040540851652622,
-0.010573109611868858,
0.017566625028848648,
-0.004312995821237564,
-0.00465768575668335,
0.002411354798823595,
0.020100120455026627,
0.01200706884264946,
-0.006292420905083418,
-0.021607082337141037,
-0.03614439815282822,
0.00534899951890111,
-0.022745221853256226,
-0.0038800970651209354,
0.014520926401019096,
0.0063137486577034,
0.03004874661564827,
0.0011943422723561525,
-0.0289028137922287,
0.010962080210447311,
-0.010899649932980537,
0.005259305238723755,
-0.0016879765316843987,
0.003825510386377573,
0.0013302317820489407,
-0.0002786328550428152,
0.019222110509872437,
-0.019176891073584557,
0.0098542720079422,
0.008575940504670143,
0.015270771458745003,
0.0312657430768013,
0.013457242399454117,
0.000036556972190737724,
0.008877407759428024,
0.016441483050584793,
0.0057972813956439495,
-0.03565407916903496,
-0.0036998228169977665,
0.012590581551194191,
-0.014145340770483017,
0.010521961376070976,
-0.007507160771638155,
0.013032324612140656,
-0.005198860540986061,
-0.005707585718482733,
-0.005591625813394785,
0.023036478087306023,
-0.017648614943027496,
0.016522975638508797,
-0.0006614564917981625,
-0.013959178701043129,
0.01240328885614872,
-0.009052976965904236,
-0.008221717551350594,
-0.014929956756532192,
-0.003845254424959421,
-0.003618564223870635,
0.022348053753376007,
-0.005524498410522938,
0.011609913781285286,
0.0037274786736816168,
0.0074337855912745,
0.0017467103898525238,
0.006931890267878771,
-0.0008439850062131882,
0.01780511811375618,
0.012282011099159718,
0.02992556430399418,
-0.02108091488480568,
0.007213639095425606,
0.014639731496572495,
-0.012829650193452835,
-0.026741398498415947,
-0.00209185853600502,
0.0208682119846344,
-0.010550282895565033,
-0.014533862471580505,
0.02396474778652191,
-0.01923234388232231,
-0.011631365865468979,
0.003799981204792857,
0.0006652455776929855,
-0.008156041614711285,
0.005559162236750126,
0.007908560335636139,
0.015028460882604122,
0.03548591583967209,
0.00969919003546238,
0.0026648403145372868,
0.03627960756421089,
0.00011474781786091626,
-0.008384916931390762,
-0.004718469455838203,
0.021117595955729485,
-0.0027699070051312447,
-0.005225750617682934,
-0.009016035124659538,
0.0013853023992851377,
0.008133241906762123,
0.011598780751228333,
0.015336615033447742,
-0.02147086337208748,
0.01708047091960907,
0.00868446659296751,
0.0007414049468934536,
0.00009376462548971176,
-0.0057320562191307545,
-0.0047137001529335976,
0.010290813632309437,
-0.013284388929605484,
-0.004767743404954672,
-0.008028492331504822,
-0.013834797777235508,
-0.00437784381210804,
0.015285074710845947,
-0.005435397382825613,
0.00570457661524415,
-0.002737112808972597,
-0.011737825348973274,
-0.013412618078291416,
0.011262904852628708,
0.0006866562180221081,
0.0036941629368811846,
-0.013729994185268879,
0.008926115930080414,
0.018466860055923462,
0.003906906582415104,
0.019794033840298653,
0.004592635203152895,
-0.00361188524402678,
0.0028527318499982357,
0.008966425433754921,
-0.007585123647004366,
0.007592539303004742,
0.001231339992955327,
0.010243576020002365,
0.02324303798377514,
0.020245261490345,
-0.005017442628741264,
0.01864890567958355,
0.011714806780219078,
0.020337101072072983,
0.003442018525674939,
0.014828929677605629,
-0.004846084397286177,
0.005274712573736906,
-0.0008153095841407776,
-0.0010801424505189061,
-0.031766969710588455,
-0.0033290518913418055,
0.0073539200238883495,
-0.005558386445045471,
0.02055053971707821,
0.00862796325236559,
0.007107315585017204,
-0.0068016028963029385,
-0.003606273327022791,
0.00047852506395429373,
-0.006414838135242462,
0.003313729539513588,
0.00835082121193409,
0.0036680083721876144,
-0.006883618421852589,
-0.009791217744350433,
0.009472738951444626,
-0.00285348785109818,
-0.01581544615328312,
0.00843009538948536,
0.017286034300923347,
-0.004580473527312279,
0.01689176633954048,
0.0062692975625395775,
-0.016410578042268753,
0.008266931399703026,
-0.0021510713268071413,
-0.012738136574625969,
0.009429828263819218,
-0.01925269141793251,
0.006738170050084591,
0.02296873927116394,
-0.0010528834536671638,
-0.01337318867444992,
-0.0056752548553049564,
-0.004544354509562254,
-0.003201136365532875,
-0.012240882031619549,
-0.001524979597888887,
-0.022315628826618195,
-0.016540799289941788,
0.009310388937592506,
0.021913792937994003,
-0.005559398327022791,
0.010810520499944687
] | [
0.3794376254081726,
-0.00585382292047143,
-0.102921262383461,
-0.32457923889160156,
-0.025689899921417236,
0.00817533116787672,
0.48799946904182434,
0.8818614482879639,
-0.45657458901405334,
-0.4080919325351715,
0.12321636825799942,
-0.3938539922237396,
-0.46574801206588745,
0.7252103686332703,
0.04789191484451294,
0.09660385549068451,
0.5960228443145752,
0.5634384155273438,
-0.4145905673503876,
0.0624622106552124,
-0.5488415360450745,
-0.46910616755485535,
0.2643144428730011,
0.4273887574672699,
0.23975563049316406,
-0.5647888779640198,
0.17215320467948914,
-0.27486762404441833,
0.32767316699028015,
-0.12004424631595612,
0.0956425592303276,
0.5019679069519043,
0.33255550265312195,
-0.37872016429901123,
-0.34360235929489136,
-0.1984902024269104,
-0.5998274087905884,
0.11646277457475662,
-0.2531779110431671,
-0.41586992144584656,
-0.4473099410533905,
-0.14327047765254974,
-0.10182678699493408,
0.4317305088043213,
0.12214692682027817,
-0.6674191951751709,
-1.124552845954895,
0.8507490158081055,
-0.17136946320533752,
0.27332407236099243,
0.08009269833564758,
-0.19375093281269073,
-0.07914679497480392,
-0.035877127200365067,
0.03605359047651291,
0.16765210032463074,
-0.505221962928772,
0.039717115461826324,
0.16141612827777863,
-0.26224908232688904,
0.5636275410652161,
-0.48516494035720825,
0.16510580480098724,
0.09384569525718689,
-0.6614143252372742,
0.445629358291626,
0.3642902076244354,
0.8451945781707764,
0.17897582054138184,
-0.5468209385871887,
-0.13836060464382172,
-0.4725434184074402,
-0.4798286557197571,
-0.2754024267196655,
0.14841262996196747,
-0.3898572623729706,
0.11559981107711792,
-0.09381891787052155,
0.09662453830242157,
0.36022982001304626,
-0.2832220494747162,
0.4226023554801941,
0.27335044741630554,
-0.48340675234794617,
0.5756912231445312,
-0.028031906113028526,
0.14082762598991394,
0.5772917866706848,
-0.04035770148038864,
0.1489759236574173,
0.201180562376976,
-0.1384415328502655,
0.6601002216339111,
-0.04393079876899719,
-0.022525671869516373,
0.07861305773258209,
0.3751366138458252,
-0.16076937317848206,
0.31054621934890747,
-0.3858993947505951,
-0.6500589847564697,
-0.01771550625562668,
0.014396177604794502,
-0.08324551582336426,
0.10585389286279678,
-0.06421639770269394,
0.11870791018009186,
-0.20567810535430908,
0.07610668241977692,
-0.2524854242801666,
0.09898241609334946,
0.07907721400260925,
-0.05371199548244476,
-0.07090741395950317,
-0.3122868239879608,
0.6468218564987183,
0.4470912218093872,
-0.6749653220176697,
0.1982225775718689,
-0.38000261783599854,
-0.3585362732410431,
0.3758765161037445,
-0.42425066232681274,
0.4360741078853607,
-0.18402662873268127,
0.11329382658004761,
0.2715027928352356,
-0.1824755221605301,
-0.2008647918701172,
0.11382348835468292,
0.03972942754626274,
0.46374472975730896,
0.06370549649000168,
-0.1459135115146637,
0.03928467631340027,
0.11980251222848892,
-0.04450792446732521,
0.43378937244415283,
0.05759938806295395,
-0.3954293429851532,
-0.2864668369293213,
-0.5722613334655762,
-0.4293590486049652,
0.29109111428260803,
0.10763158649206161,
0.01222007442265749,
-0.216568261384964,
-0.33781102299690247,
-0.11833611130714417,
-0.5104740858078003,
-0.1446506530046463,
-0.382038414478302,
-0.4704952836036682,
0.13011939823627472,
0.328002393245697,
0.2968757748603821,
-0.354753315448761,
-0.3413998484611511,
0.1497666835784912,
0.08379992097616196,
0.5270355343818665,
0.31869253516197205,
-0.08380287140607834,
-0.35170474648475647,
0.007415673229843378,
-0.10357702523469925,
0.24208708107471466,
0.4435194432735443,
-0.39322835206985474,
-0.038209497928619385,
-0.38570964336395264,
0.046261902898550034,
0.2668524384498596,
-0.28885212540626526,
-0.029116688296198845,
0.03541967272758484,
0.28893348574638367,
-0.09257572144269943,
0.3460734784603119,
0.7494212985038757,
-0.44987037777900696,
-0.02584569901227951,
0.17337100207805634,
-0.15768426656723022,
-0.13353905081748962,
-0.12340930104255676,
0.027897298336029053,
0.20234161615371704,
0.09282426536083221,
0.23817318677902222,
-0.22345922887325287,
-0.2143283486366272,
0.2882131338119507,
-0.13489943742752075,
1.123106598854065,
-0.3345429003238678,
0.0034285953734070063,
1.1319767236709595,
0.2833990156650543,
0.1949133276939392,
0.046450983732938766,
0.06656470894813538,
0.6880800724029541,
-0.38026663661003113,
-1.0019160509109497,
-0.00973336212337017,
0.06814736872911453,
-0.19838212430477142,
-0.12695087492465973,
-0.1375598907470703,
0.1459777057170868,
-0.11993782967329025,
-0.059921059757471085,
-0.2568345069885254,
0.31213000416755676,
0.5252484679222107,
-0.4010654091835022,
-0.036207303404808044,
0.134250670671463,
-0.18746501207351685,
0.06334368139505386,
-0.3560678958892822,
-0.08716526627540588,
0.11450310796499252,
0.2867943048477173,
0.3137609660625458,
0.4000692665576935,
-0.30857983231544495,
0.8240923285484314,
-1.1325745582580566,
0.08772171288728714,
-0.06740640103816986,
0.2885465621948242,
-0.6517439484596252,
-0.3798731863498688,
0.0874587818980217,
-0.11140380799770355,
0.0364358015358448,
-0.39879125356674194,
0.1339162439107895,
0.8962879776954651,
0.4121702015399933,
-0.5312828421592712,
0.1797703206539154,
-0.037451889365911484,
-0.2582438886165619,
0.1738865077495575,
-0.2930375039577484,
-0.7368130087852478,
0.1682860404253006,
0.1657535284757614,
0.5896708369255066,
0.23956513404846191,
-0.5357975363731384,
0.12562376260757446,
-0.17096564173698425,
0.2583478093147278,
0.05112355574965477,
0.9048013687133789,
0.08315306156873703,
0.08114379644393921,
-0.20058193802833557,
0.09651535749435425,
0.5014657974243164,
0.04144078865647316,
-0.7109912037849426,
-0.5810449719429016,
-0.4278719127178192,
0.27238035202026367,
0.30436190962791443,
1.0301481485366821,
0.03645259141921997,
-0.27574557065963745,
-0.0700954720377922,
0.27696019411087036,
-0.6079325079917908,
0.7218210101127625,
0.7539299726486206,
-0.21693308651447296,
-0.16738799214363098,
-0.3692651093006134,
0.18222856521606445,
0.5009205937385559,
-0.7234686017036438,
0.015156028792262077,
-0.6256426572799683,
-0.0521976612508297,
-0.28803741931915283,
-0.5363719463348389,
0.20684118568897247,
0.10853087902069092,
0.19271551072597504,
-0.041432831436395645,
0.40818992257118225,
0.003022328019142151,
-0.3009371757507324,
0.041960544884204865,
0.5224918127059937,
0.6581218242645264,
-0.06232723593711853,
-0.3311002552509308,
0.48970845341682434,
-0.5025412440299988,
-0.11478104442358017,
-0.09648863971233368,
0.42855513095855713,
-0.29479795694351196,
-0.0626499131321907,
-6.107513427734375,
0.18163780868053436,
0.00927624199539423,
-0.4141586720943451,
-0.4020276367664337,
0.25012895464897156,
0.762595534324646,
0.45751073956489563,
0.2076023668050766,
0.2395743429660797,
0.7832507491111755,
0.26125726103782654,
-0.22228257358074188,
-0.4299914240837097,
-0.522087037563324,
0.05091637745499611,
-0.31923484802246094,
-0.24838711321353912,
-0.29391857981681824,
0.06123730167746544,
-0.4989829957485199,
-0.2603164315223694,
0.01708942838013172,
0.502053439617157,
0.28231143951416016,
0.16273397207260132,
-0.7366833686828613,
0.19093506038188934,
-0.2577766478061676,
0.5202505588531494,
0.2879365384578705,
-0.8726988434791565,
-0.08587901294231415,
-0.07480359822511673,
-0.5487245917320251,
0.08666390180587769,
0.20506392419338226,
-0.6667658686637878,
-0.11138124018907547,
-0.12705716490745544,
-0.3737633526325226,
-0.1308554857969284,
-0.10640166699886322,
-0.46619024872779846,
0.45134735107421875,
0.05415935441851616,
0.02430780604481697,
0.015370365232229233,
-0.25501611828804016,
0.5141025185585022,
0.07738562673330307,
-0.09599930047988892,
-0.19124427437782288,
0.08568485826253891,
0.28068819642066956,
0.21965834498405457,
-0.1970801055431366,
0.09479214251041412,
-0.10156045854091644,
-0.262338787317276,
0.11867275089025497,
-0.09641875326633453,
0.252377986907959,
-0.06875569373369217,
0.6021263003349304,
-0.04215659201145172,
-0.6099295616149902,
-0.3449420928955078,
0.33049148321151733,
-0.020792515948414803,
-0.036047037690877914,
0.20899935066699982,
0.11463424563407898,
-0.8557941317558289,
-0.1884467452764511,
-0.7721182703971863,
-0.16233615577220917,
0.053900089114904404,
0.10653594881296158,
-0.46164998412132263,
-0.31414666771888733,
-0.02853858657181263,
0.14397914707660675,
-0.4859851598739624,
0.24515998363494873,
0.12008380889892578,
0.1173739954829216,
-0.40099450945854187,
-0.029128894209861755,
0.2608824372291565,
0.9409446120262146,
-0.5283031463623047,
0.02455122582614422,
0.27885040640830994,
0.15613774955272675,
0.6126521229743958,
0.15817204117774963,
0.48565971851348877,
0.2509240210056305,
0.27756404876708984,
0.9381427764892578,
-0.32901105284690857,
-0.5004255175590515,
-0.6561867594718933,
-0.09040941298007965,
-0.029980305582284927,
-0.29387739300727844,
0.20009969174861908,
0.9878263473510742,
-0.5890407562255859,
0.032846879214048386,
0.07444511353969574,
-0.40646445751190186,
0.22324909269809723,
0.41752833127975464,
-0.09872844815254211,
0.1530715525150299,
0.5071203112602234,
0.7641983032226562,
-0.1965048909187317,
0.4635554552078247,
0.5845372676849365,
-0.2601737678050995,
0.5359431505203247,
0.7366300821304321,
-0.1821260303258896,
0.21247455477714539,
0.23419393599033356,
-0.23123352229595184,
-0.39716291427612305,
0.36459586024284363,
0.30014315247535706,
-0.07807371020317078,
-0.19352923333644867,
0.47211578488349915,
0.19737163186073303,
-0.4221508502960205,
-0.6320059299468994,
0.39953309297561646,
0.17200788855552673,
-0.4975159168243408,
0.24595364928245544,
-0.040318798273801804,
-0.15353257954120636,
0.11823955923318863,
-0.04783182591199875,
0.05299391970038414,
-0.18704332411289215,
-0.1916290521621704,
-0.3616173267364502,
0.18538735806941986,
0.32739463448524475,
0.022539423778653145,
0.27213814854621887,
-1.1716009378433228,
0.33441662788391113,
0.9574941396713257,
0.09908179938793182,
-0.4914688169956207,
-0.1717955768108368,
0.29658666253089905,
-0.35123205184936523,
-0.8339390158653259,
0.17839409410953522,
0.09643480181694031,
-0.040530700236558914,
0.3706936240196228,
-0.5156285166740417,
0.041171420365571976,
0.2048165500164032,
-0.2377697080373764,
-0.22473689913749695,
-0.1910053789615631,
0.31331226229667664,
0.0806063562631607,
0.1730041652917862,
-0.5433568954467773,
-0.24609443545341492,
0.061316296458244324,
0.47691529989242554,
0.024698173627257347,
-0.2318469136953354,
-0.7479071021080017,
0.486670583486557,
0.4691975712776184,
0.2530228793621063,
-0.02384846657514572,
-0.23432661592960358,
-0.4424237906932831,
0.0003336886584293097,
0.43203431367874146,
0.005274928640574217,
-0.1492632031440735,
0.45524120330810547,
-0.10777482390403748,
-0.2644454836845398,
-0.49727824330329895,
-0.19825807213783264,
-0.15239103138446808,
-0.14226652681827545,
0.05407942086458206,
0.4209154546260834,
-0.17502152919769287,
-0.04962370917201042,
0.3244383931159973,
-0.3178788721561432,
-0.1250266134738922,
-0.2089424431324005,
-0.1970674991607666,
-0.25325512886047363,
0.11549137532711029,
-0.07918417453765869,
-0.4307407736778259,
0.8513506650924683,
0.1481596678495407,
0.019996430724859238,
-0.20958773791790009,
-0.4903163015842438,
0.0227188840508461,
0.2612050473690033,
-0.12280186265707016,
0.3423362076282501,
-0.21036122739315033,
-0.2250491976737976,
-0.2848295569419861,
0.9365596771240234,
0.2790919244289398,
-0.7861841320991516,
0.018962958827614784,
-0.2490706592798233,
0.017533807083964348,
0.10932820290327072,
0.2107383906841278,
0.4224074184894562,
-0.4140882194042206,
-0.1106795221567154,
0.41564273834228516,
-0.44572046399116516,
0.1178109273314476,
0.7699708938598633,
0.09710104763507843,
0.13332656025886536,
0.020384198054671288,
-0.515084445476532,
0.034313734620809555,
-0.09396348893642426,
-0.07349211722612381,
-0.22254729270935059,
0.234682098031044,
-0.05568329244852066,
-0.3971247375011444,
-0.5843313336372375,
0.18701618909835815,
0.14329871535301208,
0.3829372823238373,
-0.2760280966758728,
-0.07179310917854309,
-0.39921367168426514,
-0.3491402864456177,
-0.9381240010261536,
-0.06559955328702927,
-0.48657941818237305,
-0.3535468578338623,
0.36379751563072205,
0.14446790516376495,
-0.23718953132629395,
-0.5503859519958496,
-0.0628988966345787,
-0.06105004996061325,
-0.02657969854772091,
-0.03343842178583145,
-0.20367899537086487,
0.5354976654052734,
0.2878921926021576,
0.24783991277217865,
0.3609796166419983,
-0.36860689520835876,
-0.07933797687292099,
-0.291978657245636,
0.38167330622673035,
-0.33817869424819946,
-0.3987612724304199,
0.13860760629177094,
-0.1687096208333969,
0.5553687214851379,
-0.3894856870174408,
0.053447429090738297,
-0.3025997579097748,
0.180918350815773,
-0.5948981642723083,
-0.21229396760463715,
0.30227333307266235,
-0.19856303930282593,
-0.15410172939300537,
0.1317541003227234,
0.07320556044578552,
0.1970115303993225,
0.2571795880794525,
0.2708069980144501,
-0.4513208568096161,
-0.7016853094100952,
0.44329842925071716,
0.2991061508655548,
-0.30477651953697205,
0.08102787286043167,
-0.02250003069639206,
-0.0013767614727839828,
0.5893496870994568,
-0.2569829225540161,
0.17396731674671173,
0.4108797013759613,
0.20847240090370178,
-0.09116718173027039,
0.32769590616226196,
-0.7749121189117432,
0.4186819791793823,
-0.23198625445365906,
-0.48889225721359253,
0.15519946813583374,
-0.19797860085964203,
0.15181756019592285,
0.6513735055923462,
0.15507249534130096,
-0.2694789171218872,
-0.10213346779346466,
0.39973577857017517,
0.1387116014957428,
0.5315998792648315,
-0.3450198769569397,
0.44293084740638733,
0.40395253896713257,
0.0978197529911995,
-0.3732537627220154,
0.23384317755699158,
-0.057129666209220886,
0.20696453750133514,
0.28410494327545166,
-0.4010932147502899,
-0.39977380633354187,
-0.03671257197856903,
0.747039794921875,
-0.000881295301951468,
-0.07675153017044067,
-0.0049869283102452755,
-0.1350403130054474,
-0.08251908421516418,
-0.04590921476483345,
0.10970659554004669,
0.4638482630252838,
0.14526911079883575,
0.43319305777549744,
-0.052351661026477814,
0.16339661180973053,
0.41898852586746216,
0.060230374336242676,
-0.09931078553199768,
-0.009356258437037468,
-0.190064936876297,
-0.7364563345909119,
-0.35984092950820923,
0.4061641991138458,
0.19480472803115845,
0.44020968675613403,
0.2181379646062851,
0.4883688986301422,
0.2742328345775604,
0.03919944539666176,
-0.04715241119265556,
-0.14692258834838867,
-0.3634379208087921,
0.15105248987674713,
-0.3284446895122528,
-0.44971928000450134,
0.14250299334526062,
0.568057119846344,
0.22118744254112244,
0.14707304537296295,
0.18632598221302032,
-0.10164975374937057,
0.39328309893608093,
-0.5969776511192322,
-0.45894214510917664,
-0.129668191075325,
-0.32328179478645325,
-0.24703723192214966,
0.10529690980911255,
-0.3404771685600281,
0.14380457997322083,
-0.248685821890831,
-0.2071733921766281,
-0.09415120631456375,
-0.5383175611495972,
0.0907057449221611,
0.41885489225387573,
-0.00844054576009512,
-0.06820664554834366,
0.20044919848442078,
0.6837877631187439,
-0.1107003465294838,
0.3352627158164978,
0.3271351754665375,
-0.2807910740375519,
-0.2605127692222595,
0.2950388491153717,
-0.5683614611625671,
0.6030876636505127,
-0.3662340044975281,
-0.26360422372817993,
-0.2667703330516815,
0.4191201329231262,
0.6247859001159668,
0.049757592380046844,
-0.04689883440732956,
0.09632185101509094,
-0.527230978012085,
0.09435538947582245,
0.5795758962631226,
-0.43250277638435364,
-0.06311411410570145,
-0.8203147053718567,
-0.3337073028087616,
-0.6387216448783875,
-0.2553030550479889,
0.1400824338197708,
0.06403613090515137,
0.14350052177906036,
0.4380389153957367,
0.6573946475982666,
-0.21278396248817444,
0.5927369594573975,
-0.39064472913742065,
0.11815909296274185,
-0.37100887298583984,
0.22014664113521576,
-0.315844863653183,
-0.1806139051914215,
0.6881145238876343,
0.24311307072639465,
0.1615232527256012,
0.1961372196674347,
0.42953863739967346,
-0.28326544165611267,
0.08950379490852356,
-0.27291491627693176,
0.20232203602790833,
0.2628399133682251,
-0.09066099673509598,
0.1248638704419136,
-0.5361546277999878,
0.30541113018989563,
-0.025284113362431526,
0.07786672562360764,
-0.16727711260318756,
0.07918257266283035,
0.09370969980955124,
0.46029019355773926,
0.3253016769886017,
-0.28059476613998413,
0.19570712745189667,
-0.3898000717163086
] |
We consider a stochastic susceptible-exposed-infected-recovered (SEIR) epidemiological model. Through the use of a normal form coordinate transform, we are able to analytically derive the stochastic center manifold along with the associated, reduced set of stochastic evolution equations. The transformation correctly projects both the dynamics and the noise onto the center manifold. Therefore, the solution of this reduced stochastic dynamical system yields excellent agreement, both in amplitude and phase, with the solution of the original stochastic system for a temporal scale that is orders of magnitude longer than the typical relaxation time. This new method allows for improved time series prediction of the number of infectious cases when modeling the spread of disease in a population. Numerical solutions of the fluctuations of the SEIR model are considered in the infinite population limit using a Langevin equation approach, as well as in a finite population simulated as a Markov process. | [
0.0021604024805128574,
0.01169014535844326,
-0.013945506885647774,
0.014281217940151691,
0.0025905161164700985,
-0.011343094520270824,
0.009314934723079205,
0.0008956023957580328,
-0.008612364530563354,
-0.02375676855444908,
-0.008121727034449577,
0.014074182137846947,
-0.002314146375283599,
-0.00010438653407618403,
0.015156228095293045,
0.007185338996350765,
-0.0059302691370248795,
-0.004191065672785044,
0.005821412894874811,
-0.01623833365738392,
0.013037984259426594,
0.00870504043996334,
0.010212857276201248,
0.03248119354248047,
-0.017313752323389053,
0.004650724586099386,
-0.007402679417282343,
-0.003294497961178422,
0.007428017910569906,
-0.008317653089761734,
-0.009142487309873104,
0.009942798875272274,
0.00001048925332725048,
0.024706723168492317,
0.0037601571530103683,
0.010227978229522705,
-0.008771292865276337,
0.02286209724843502,
0.012339692562818527,
-0.005200684070587158,
0.010236831381917,
-0.008576588705182076,
0.006701354868710041,
-0.01016334816813469,
-0.007468733936548233,
0.0004908796399831772,
0.0019512103172019124,
-0.005326760001480579,
-0.004156067967414856,
-0.00015864893794059753,
-0.008056782186031342,
-0.005160762928426266,
-0.006525798700749874,
0.002106331055983901,
-0.005782526917755604,
-0.006946000270545483,
0.017657924443483353,
0.027974789962172508,
-0.0205230675637722,
-0.006575155071914196,
-0.01794605702161789,
0.024011196568608284,
-0.001863736193627119,
-0.029532961547374725,
-0.001901507144793868,
-0.06750472635030746,
0.014489619992673397,
0.02202911488711834,
0.0029965240973979235,
0.012907115742564201,
-0.009836167097091675,
0.005499511957168579,
-0.00955226831138134,
-0.024617426097393036,
-0.01808326132595539,
0.013842268846929073,
-0.010020806454122066,
0.00982128456234932,
0.0130778718739748,
-0.017677437514066696,
0.0024245413951575756,
0.007043538615107536,
0.009878033772110939,
0.011482059955596924,
-0.012596006505191326,
0.008896224200725555,
-0.012856340035796165,
0.014720449224114418,
0.010146670043468475,
0.011749258264899254,
-0.014533452689647675,
-0.0011391770094633102,
-0.019779769703745842,
0.007883436046540737,
0.00818652380257845,
0.010252270847558975,
-0.012576334178447723,
0.0050673652440309525,
-0.021689612418413162,
-0.00275640026666224,
-0.01700899936258793,
0.016016682609915733,
0.015605365857481956,
-0.004609572701156139,
0.006885593757033348,
0.00812010932713747,
-0.014209266752004623,
0.0081801638007164,
-0.00787312537431717,
0.005331024993211031,
0.013330690562725067,
0.0006106304936110973,
0.002586783142760396,
0.00623710174113512,
-0.00692793121561408,
-0.006191150285303593,
-0.009194332174956799,
0.007805312983691692,
0.003537056501954794,
-0.009082460775971413,
-0.01399502158164978,
0.0021429560147225857,
0.0063675278797745705,
0.012908510863780975,
0.005086652003228664,
0.014527086168527603,
-0.03421537205576897,
0.00397126842290163,
-0.0031208358705043793,
-0.004664686508476734,
-0.00958268903195858,
0.006318271160125732,
0.03509994596242905,
-0.017163867130875587,
0.003520646132528782,
-0.00008444482227787375,
-0.015214812010526657,
0.0029717753641307354,
-0.00941691268235445,
-0.022726822644472122,
0.003175283782184124,
0.010453940369188786,
-0.0034302081912755966,
0.011450069956481457,
0.014664238318800926,
0.0023080133832991123,
-0.007341186050325632,
0.0023094567004591227,
-0.010245569050312042,
-0.01978592947125435,
0.0027843592688441277,
-0.004131102003157139,
-0.005196643061935902,
-0.0017265414353460073,
-0.027745291590690613,
0.005506797693669796,
-0.017428018152713776,
-0.01721210964024067,
-0.0036294395104050636,
0.0017951095942407846,
-0.011793063022196293,
0.018270298838615417,
-0.006378487683832645,
0.007653002627193928,
0.02266203612089157,
-0.004404838662594557,
0.01560492254793644,
0.0058272709138691425,
-0.001421907334588468,
0.003422156907618046,
-0.0007374414708465338,
-0.004884171765297651,
0.01211552508175373,
0.011319329030811787,
0.02501942217350006,
-0.0032159772235900164,
-0.0020779315382242203,
0.00756019726395607,
-0.014199888333678246,
0.06698489189147949,
0.008458344265818596,
0.006803940515965223,
0.007094185799360275,
0.008811990730464458,
-0.007925350219011307,
-0.0075739482417702675,
0.00316562014631927,
0.0003152191056869924,
-0.01159154437482357,
0.001489168033003807,
-0.011976978741586208,
-0.019243817776441574,
-0.005580861587077379,
-0.0027721794322133064,
-0.006515529938042164,
0.003071665298193693,
0.014360815286636353,
-0.011646142229437828,
-0.01564689166843891,
0.01575690135359764,
0.011921893805265427,
-0.01073623076081276,
0.04245942458510399,
0.0264201108366251,
-0.015324924141168594,
0.012490032240748405,
0.012435508891940117,
-0.038032740354537964,
0.005877973046153784,
0.01940852776169777,
0.016575489193201065,
-0.03252902999520302,
-0.004692044574767351,
-0.0029226921033114195,
-0.003849357133731246,
-0.002624065615236759,
0.007039801217615604,
0.01204332709312439,
0.003991289529949427,
-0.011029419489204884,
-0.003386088414117694,
0.0035298564471304417,
-0.006637263111770153,
0.0008292896673083305,
0.012983568012714386,
-0.0152770159766078,
-0.004021125845611095,
0.011558357626199722,
0.0011981071438640356,
-0.001685782102867961,
-0.030452899634838104,
-0.018855661153793335,
-0.011213064193725586,
-0.02358175441622734,
0.030979357659816742,
0.021744325757026672,
0.009831522591412067,
0.007210030220448971,
0.013160180300474167,
-0.009689994156360626,
-0.017690949141979218,
-0.016968348994851112,
-0.0006665638647973537,
-0.008208537474274635,
-0.01691223494708538,
0.0035229711793363094,
-0.006352922413498163,
0.0008650985546410084,
0.021456871181726456,
0.0034744632430374622,
0.004983493126928806,
-0.02896910160779953,
-0.005956588312983513,
0.01797151379287243,
0.017032582312822342,
-0.01342991553246975,
0.010715290904045105,
0.01488110888749361,
0.022845931351184845,
-0.0056816390715539455,
-0.005067926831543446,
0.002956836950033903,
0.01174249965697527,
0.003677160246297717,
0.01821596547961235,
-0.004503694828599691,
-0.013905650936067104,
-0.0007776019629091024,
0.029988786205649376,
0.027949299663305283,
0.004718842450529337,
-0.010966671630740166,
0.00022641336545348167,
-0.08103905618190765,
-0.01452432107180357,
0.014188706874847412,
0.0017770517151802778,
0.0066749705001711845,
0.007028485182672739,
-0.002088997745886445,
-0.008635926991701126,
-0.010884529910981655,
0.01563340425491333,
-0.005273846443742514,
0.018404074013233185,
-0.01081813033670187,
-0.006969453766942024,
0.006044462323188782,
-0.000025496468879282475,
0.011547071859240532,
-0.0023352503776550293,
0.013967445120215416,
0.02080603502690792,
0.0015306007117033005,
-0.005409738048911095,
0.011146407574415207,
0.00047773984260857105,
-0.01580379530787468,
0.0074612172320485115,
0.007360369898378849,
-0.0003164474619552493,
-0.0020964588038623333,
0.0032699494622647762,
0.011394688859581947,
-0.0076810154132544994,
0.009192271158099174,
-0.012714275158941746,
0.0015536006540060043,
-0.0016224745195358992,
0.006313302554190159,
-0.023893315345048904,
-0.0077422852627933025,
0.004713994916528463,
0.0033057858236134052,
0.009684005752205849,
0.025585681200027466,
0.015533298254013062,
0.0018936493434011936,
0.0035082162357866764,
0.02561241015791893,
0.0050562904216349125,
0.009713822975754738,
0.009111656807363033,
-0.007546823937445879,
-0.007993265986442566,
-0.010550754144787788,
0.015979282557964325,
-0.006523115560412407,
-0.005617513321340084,
-0.04249850660562515,
-0.001720799133181572,
-0.007580857258290052,
-0.0059279934503138065,
-0.002333768643438816,
-0.023191235959529877,
-0.009145084768533707,
-0.010334130376577377,
0.005892882123589516,
0.0059541440568864346,
0.0006591557757928967,
0.017149321734905243,
-0.009033866226673126,
-0.0016191938193514943,
0.009569201618432999,
-0.010520854964852333,
0.006593986880034208,
-0.006611987948417664,
-0.0031481129117310047,
-0.010165620595216751,
-0.009715489111840725,
0.0006986300577409565,
-0.006509869359433651,
-0.022940626367926598,
-0.022988801822066307,
0.004823514260351658,
0.015678787603974342,
0.0029730552341789007,
-0.021321482956409454,
-0.005409483797848225,
0.006657023914158344,
-0.001538255950435996,
0.006013368256390095,
-0.014956656843423843,
-0.0015224209055304527,
0.0013040744233876467,
-0.023305054754018784,
0.008117436431348324,
0.0009107743389904499,
-0.02490568347275257,
-0.004676622338593006,
-0.004649384878575802,
0.009968548081815243,
0.009322592057287693,
0.000302022323012352,
-0.0027176043950021267,
0.0124274343252182,
-0.012151084840297699,
-0.03947857767343521,
0.012330415658652782,
0.0033594348933547735,
0.010930510237812996,
0.00165931461378932,
-0.0022696652449667454,
-0.009712671861052513,
-0.003784470958635211,
-0.003903286764398217,
0.02077561803162098,
0.011889811605215073,
0.028354814276099205,
0.0014276540605351329,
0.010302103124558926,
0.07285311818122864,
0.006916244979947805,
-0.004995475988835096,
-0.006479299161583185,
-0.0030586004722863436,
-0.007300825323909521,
-0.001726543065160513,
-0.006374099757522345,
-0.007581242360174656,
0.0006152521818876266,
0.010783585719764233,
0.015028783120214939,
0.010078118182718754,
0.009188517928123474,
-0.01933826133608818,
-0.006830105558037758,
-0.0015118422452360392,
0.004787932615727186,
-0.016734495759010315,
0.0028823669999837875,
-0.004948240704834461,
-0.021085554733872414,
-0.015817992389202118,
0.008105773478746414,
0.016213059425354004,
-0.004035091493278742,
0.004968981724232435,
-0.016856234520673752,
-0.0021112130489200354,
0.009863561019301414,
-0.007056726608425379,
-0.007643925026059151,
-0.006990295369178057,
-0.015995487570762634,
-0.004839283414185047,
-0.006736041512340307,
0.006315317004919052,
-0.004016539081931114,
0.00034297152888029814,
0.011856968514621258,
0.008611973375082016,
-0.014183667488396168,
0.014733287505805492,
0.013876805081963539,
0.004422993864864111,
0.013612676411867142,
-0.0003077028086408973,
-0.005438939668238163,
-0.0032519192900508642,
-0.008784678764641285,
-0.009948667138814926,
0.010859822854399681,
0.014841082505881786,
0.020672066137194633,
0.020142000168561935,
0.01704956404864788,
0.0014563649892807007,
0.004008285701274872,
-0.0013429282698780298,
0.006567802745848894,
-0.0042225974611938,
-0.03455553576350212,
0.00876766350120306,
-0.022801844403147697,
-0.010013492777943611,
-0.016058960929512978,
-0.005274703726172447,
-0.006915622856467962,
-0.003702616086229682,
0.0057624587789177895,
0.011513711884617805,
0.0014424649998545647,
-0.010386711917817593,
0.00006122980266809464,
-0.002622116357088089,
0.00233057071454823,
-0.012613559141755104,
0.006770395673811436,
0.009477448649704456,
0.03376385569572449,
-0.0006978868041187525,
-0.015070161782205105,
-0.018035780638456345,
0.008476425893604755,
0.006527415476739407,
-0.025028899312019348,
-0.014218595810234547,
-0.07510535418987274,
-0.0003842925652861595,
0.011525209993124008,
-0.005499145016074181,
0.004442582838237286,
-0.0007337597198784351,
-0.000831657787784934,
0.003470619907602668,
0.01737087219953537,
-0.00652043242007494,
-0.013078024610877037,
-0.019355271011590958,
0.0036878124810755253,
0.00785432942211628,
0.010012655518949032,
-0.001984207658097148,
0.012289989739656448,
-0.005704435054212809,
-0.005811520852148533,
0.003378012916073203,
-0.02893684431910515,
-0.012769175693392754,
0.004329218529164791,
-0.009471921250224113,
-0.003031985368579626,
-0.08183188736438751,
0.004457666072994471,
-0.024499401450157166,
-0.005738978274166584,
-0.010709395632147789,
-0.017921019345521927,
-0.005532049108296633,
0.001075024832971394,
0.0038434420712292194,
-0.012094240635633469,
0.004384423606097698,
-0.003546209540218115,
-0.01439271867275238,
-0.006794343236833811,
0.01096478570252657,
-0.003667950863018632,
0.01073495578020811,
-0.01555064506828785,
-0.010756435804069042,
-0.0255133006721735,
0.015489629469811916,
-0.01091175340116024,
-0.008948812261223793,
-0.013697486370801926,
-0.002029962372034788,
-0.004611611366271973,
-0.010672018863260746,
0.00800422765314579,
0.012449223548173904,
0.008469623513519764,
0.0117192342877388,
0.029301835224032402,
0.007377782836556435,
-0.0038078674115240574,
0.005773693323135376,
-0.011868758127093315,
0.005724664777517319,
-0.006029070820659399,
0.007654222659766674,
0.009787667542696,
-0.0023920906241983175,
0.016333356499671936,
0.0005571274086833,
-0.008492124266922474,
-0.011765947565436363,
-0.01157565601170063,
0.005191058851778507,
-0.005387254059314728,
0.0073001994751393795,
0.007147585973143578,
-0.00330980122089386,
-0.021635105833411217,
0.016467735171318054,
-0.004556629341095686,
0.010205179452896118,
0.0077743567526340485,
-0.0004753468092530966,
0.02135413885116577,
0.017903583124279976,
0.0035954767372459173,
0.0010803812183439732,
-0.01472110953181982,
-0.009849430061876774,
0.07196320593357086,
-0.009664041921496391,
0.016599921509623528,
0.01083066500723362,
-0.006061319261789322,
-0.00010360847227275372,
-0.034585922956466675,
-0.04356447234749794,
0.005745311267673969,
-0.014036232605576515,
0.019060123711824417,
0.001611221581697464,
-0.008986548520624638,
0.011689076200127602,
0.007598166354000568,
-0.015233307145535946,
-0.0039004874415695667,
0.0021460517309606075,
-0.0015848230104893446,
0.018295342102646828,
0.00417007552459836,
-0.00097807333804667,
-0.009200699627399445,
0.01866677775979042,
0.03873926401138306,
0.007409443613141775,
0.007106706500053406,
0.0181275624781847,
-0.005106582306325436,
0.018112383782863617,
-0.002359232399612665,
-0.011826284229755402,
0.005672024562954903,
-0.0031638373620808125,
0.01913503184914589,
0.014850938692688942,
-0.001391072291880846,
0.003585995174944401,
0.0029394349548965693,
0.016539203003048897,
-0.011523522436618805,
0.004191570915281773,
-0.0000027343048714101315,
-0.006198970600962639,
-0.004100460559129715,
-0.020615804940462112,
0.017445867881178856,
-0.015472395345568657,
-0.010725583881139755,
0.010851062834262848,
0.008638311177492142,
0.004544809460639954,
0.00331045757047832,
-0.012530430220067501,
0.008345196954905987,
0.02173605188727379,
0.006322781089693308,
0.00915815494954586,
-0.005048787221312523,
-0.012402806431055069,
-0.0044312188401818275,
-0.008672712370753288,
0.0024805511347949505,
-0.0136385103687644,
0.009942486882209778,
0.0006333080818876624,
-0.002117323223501444,
-0.005586306098848581,
-0.02390935644507408,
0.014362339861690998,
-0.024454370141029358,
0.005876396782696247,
0.004607671871781349,
0.007567469030618668,
0.007661652285605669,
-0.0030990727245807648,
0.02003154344856739,
0.010700853541493416,
0.01800421066582203,
-0.0000676177442073822,
-0.002561157336458564,
0.016938867047429085,
0.0024531185626983643,
-0.008894259110093117,
0.017619628459215164,
-0.004562299698591232,
-0.009358871728181839,
0.009013382717967033,
0.004391608294099569,
0.00882028043270111,
0.02275451272726059,
0.011758829466998577,
-0.0014711531111970544,
0.007240858394652605,
0.0050798156298696995,
0.03271247074007988,
0.021859196946024895,
0.0062106335535645485,
0.012141574174165726,
-0.001109920209273696,
0.019658463075757027,
0.010229355655610561,
0.006583367474377155,
-0.007011570036411285,
-0.0002526275347918272,
-0.009409786202013493,
0.010740930214524269,
0.024374183267354965,
-0.023812677711248398,
-0.014778349548578262,
0.006148756947368383,
0.015249205753207207,
-0.019190713763237,
-0.00968853384256363,
-0.001310921274125576,
0.0012528705410659313,
-0.01886056736111641,
-0.029769422486424446,
0.010839858092367649,
-0.007750539109110832,
-0.012087853625416756,
0.007202778942883015,
0.0068636732175946236,
0.007256139535456896,
-0.010988849215209484,
-0.015517818741500378,
-0.005633526481688023,
-0.022703882306814194,
-0.007575841620564461,
0.012013979256153107,
0.01159262377768755,
0.007013915106654167,
-0.01892680674791336,
0.0011032649781554937,
0.004106565378606319,
-0.027109796181321144,
0.00031754624797031283,
-0.004020536784082651,
0.003390432335436344,
0.0236927829682827,
0.022053774446249008,
-0.00959044974297285,
0.00522046722471714,
-0.0005835462361574173,
0.006694722920656204,
-0.01068291999399662,
0.008994534611701965,
0.00551479822024703,
0.01583831012248993,
-0.0006739646196365356,
0.005572246853262186,
0.006610048469156027,
0.015510831028223038,
-0.006849716883152723,
-0.02886398881673813,
0.015932030975818634,
0.005127066280692816,
0.014108387753367424,
-0.008147568441927433,
-0.008466803468763828,
-0.0015046789776533842,
0.010886318981647491,
0.002101399702951312,
-0.0074326652102172375,
0.003673229366540909,
-0.010799860581755638,
0.020375477150082588,
0.0045656366273760796,
-0.013249373994767666,
0.006561024114489555,
-0.01024671457707882,
0.010538388043642044,
0.001053627929650247,
0.0024015014059841633,
-0.02835967019200325,
-0.016305075958371162,
0.007532178889960051,
0.012383685447275639,
-0.01033755112439394,
-0.0003366749733686447,
0.0024205935187637806,
0.007021828088909388,
0.011366503313183784,
-0.009191611781716347,
-0.0008091703057289124,
0.0021537202410399914,
-0.01068249810487032,
0.004689213819801807,
-0.0017371211433783174,
0.0003746813163161278,
-0.013994359411299229,
-0.0050460644997656345,
-0.003859149059280753,
0.00861215777695179,
-0.010367006063461304,
0.0067234942689538,
0.00004603574052453041,
-0.0011495305225253105,
0.005743059329688549,
-0.009424842894077301,
0.014432431198656559,
-0.0070993974804878235
] | [
-0.3539976477622986,
-0.47337606549263,
0.2306605577468872,
0.11337896436452866,
-0.12350495159626007,
0.43031853437423706,
0.08566614985466003,
-0.3743518888950348,
0.07608335465192795,
-0.8891070485115051,
-0.21003830432891846,
0.40526083111763,
-0.32623928785324097,
0.1613658368587494,
0.15530988574028015,
0.46111831068992615,
0.48532599210739136,
0.05237150564789772,
-0.36270445585250854,
-0.6076850295066833,
0.04062242433428764,
-0.08543341606855392,
0.20292992889881134,
0.2325151115655899,
0.15331408381462097,
-0.32737892866134644,
0.5031136870384216,
0.17259283363819122,
0.47837838530540466,
-0.17409957945346832,
-0.12079984694719315,
0.7926074862480164,
-0.47227174043655396,
-0.4722244143486023,
-0.2000000774860382,
0.24785497784614563,
-0.11005965620279312,
-0.010580068454146385,
-0.12749795615673065,
-0.19173939526081085,
0.12119195610284805,
-0.0976114571094513,
-0.34528982639312744,
0.3281153738498688,
-0.2539227604866028,
-0.8446155786514282,
-1.2552894353866577,
-0.15504607558250427,
-0.027318039909005165,
-0.36485955119132996,
-0.0515507310628891,
0.22809389233589172,
0.45792534947395325,
0.2856500744819641,
-0.4888395369052887,
-0.19581586122512817,
-0.5133273005485535,
-0.2907947301864624,
0.6480967402458191,
-0.12970991432666779,
-0.07512805610895157,
-0.11800234764814377,
-0.24797195196151733,
-0.13335691392421722,
-0.3318144977092743,
0.95518958568573,
0.40695035457611084,
-0.19864203035831451,
-0.3623138666152954,
-0.47638341784477234,
0.1857786923646927,
-0.4876171052455902,
-0.36342546343803406,
0.38461458683013916,
-0.14759129285812378,
-0.14486344158649445,
0.028033901005983353,
-0.19517512619495392,
-0.0456085130572319,
0.13118876516819,
-0.14099235832691193,
0.14131653308868408,
0.36399123072624207,
-0.670503556728363,
0.9705866575241089,
0.3117697834968567,
-0.19890615344047546,
0.8049588799476624,
-0.8059557676315308,
0.35767948627471924,
-0.11282224208116531,
-0.09831709414720535,
0.28483521938323975,
0.24959394335746765,
0.4477483332157135,
0.8694004416465759,
0.5176601409912109,
-0.13159248232841492,
0.3061739504337311,
0.44593557715415955,
-0.2860385775566101,
0.05815964192152023,
-0.22569462656974792,
-0.7801588177680969,
0.11916574090719223,
-0.6019214987754822,
-0.4024169445037842,
-0.43318507075309753,
-0.636130154132843,
0.0919073298573494,
-0.6184308528900146,
0.4892852008342743,
-0.22091327607631683,
-0.31421414017677307,
-0.23019887506961823,
0.1060563400387764,
0.24331283569335938,
-0.2694391906261444,
-0.05337245389819145,
0.3818607032299042,
-0.011230815201997757,
1.0210521221160889,
0.03336362540721893,
0.596917450428009,
0.17370015382766724,
-0.005683539435267448,
0.5055124163627625,
0.5348973870277405,
-0.5971717238426208,
0.3770016133785248,
0.21525509655475616,
0.7841324210166931,
-0.002953906077891588,
0.3028561472892761,
-0.008897480554878712,
-0.4640432596206665,
-0.03826284036040306,
0.34231096506118774,
-0.3900443911552429,
0.07042984664440155,
-0.3873944580554962,
-0.4927976727485657,
-0.31871917843818665,
0.04880426451563835,
-0.0824739933013916,
-0.3621862828731537,
-0.45624840259552,
-0.1415156126022339,
0.08133143931627274,
-0.15414537489414215,
-0.23821766674518585,
0.2671336233615875,
-0.90093994140625,
-0.05070910230278969,
-0.22065718472003937,
0.5338843464851379,
-0.05323639512062073,
-0.1508418768644333,
-0.01070462353527546,
0.5434266924858093,
0.4832364022731781,
0.2604665160179138,
-0.3998984694480896,
-0.4514082670211792,
0.25198808312416077,
-0.6890224814414978,
0.036114174872636795,
0.42491084337234497,
0.2899261713027954,
0.0455777645111084,
-0.27742114663124084,
-0.21714767813682556,
-0.07063279300928116,
-0.6014384031295776,
0.08487968146800995,
0.35280683636665344,
0.25135043263435364,
-0.09685588628053665,
0.17135997116565704,
0.19960959255695343,
-0.811581015586853,
-0.19035446643829346,
0.03479741886258125,
-0.6654551029205322,
0.10723139345645905,
0.1506342738866806,
0.3840152323246002,
-0.07386522740125656,
-0.040336646139621735,
0.3146986961364746,
-0.6273571252822876,
-0.03520534932613373,
0.40395721793174744,
-0.8485600352287292,
1.2712904214859009,
0.17165039479732513,
-0.04167095944285393,
1.1568673849105835,
-0.0974353700876236,
-0.027305833995342255,
0.0407479889690876,
-0.2812265455722809,
0.24907176196575165,
-0.23728793859481812,
-0.5819891691207886,
0.29531794786453247,
0.05645520240068436,
-0.07063966989517212,
-0.2982022762298584,
-0.14705140888690948,
0.6401835680007935,
-0.029714150354266167,
0.1948886215686798,
-0.5313873887062073,
0.2544560730457306,
0.10640399158000946,
-0.41519835591316223,
0.040802180767059326,
0.19813455641269684,
-0.17468833923339844,
0.8781549334526062,
-0.18377815186977386,
0.567838728427887,
0.519668698310852,
-0.04005754366517067,
0.847772479057312,
0.8975323438644409,
0.5270256996154785,
1.0942140817642212,
-0.7272273898124695,
-0.14711695909500122,
-0.43660905957221985,
0.14003941416740417,
-0.3151535391807556,
-0.42713096737861633,
0.13723810017108917,
0.12038633227348328,
-0.39913395047187805,
0.09948813170194626,
-0.056079067289829254,
0.31103429198265076,
0.6324504613876343,
-0.5545098185539246,
0.1572229564189911,
0.014163394458591938,
-0.3182002305984497,
-0.08295764029026031,
0.09068283438682556,
-0.5244810581207275,
-0.004401060286909342,
-0.06365992873907089,
0.6048989295959473,
0.10698147863149643,
-0.8923443555831909,
0.4051876664161682,
0.1279437094926834,
-0.17788487672805786,
0.028029901906847954,
-0.10437288135290146,
0.21814899146556854,
-0.2313266545534134,
0.030959032475948334,
-0.15845456719398499,
0.14085820317268372,
-0.1148393377661705,
-0.33762186765670776,
-0.7968926429748535,
-0.32732918858528137,
0.4809514582157135,
0.5724720358848572,
0.6025594472885132,
-0.44811928272247314,
-0.32879260182380676,
0.12699414789676666,
-0.19427630305290222,
-0.8072541356086731,
0.2436651736497879,
0.6296241879463196,
-0.6487196683883667,
-0.43259572982788086,
0.06354127824306488,
0.7437061667442322,
0.5826335549354553,
-0.03643578663468361,
-0.42974644899368286,
-0.11525219678878784,
0.12096662074327469,
0.2022188901901245,
-0.7588903903961182,
-0.29909414052963257,
-0.05218787491321564,
0.4105074405670166,
0.023193342611193657,
-0.09407907724380493,
0.36151933670043945,
0.45211875438690186,
0.10281789302825928,
0.16677144169807434,
0.5735982656478882,
-0.2260829210281372,
-0.6221546530723572,
0.32742905616760254,
-0.033747486770153046,
-0.13750213384628296,
-0.2930060029029846,
-0.14340049028396606,
-0.447742223739624,
0.6813616156578064,
-5.921327590942383,
-0.3064461350440979,
-0.16346214711666107,
0.42750802636146545,
-0.2438167929649353,
0.2219175100326538,
0.8404450416564941,
-0.16589176654815674,
0.126241073012352,
0.12668220698833466,
0.30015328526496887,
0.3907870054244995,
-0.09530364722013474,
0.262536883354187,
0.1661011278629303,
-0.22583045065402985,
0.10210679471492767,
0.41781914234161377,
0.29753217101097107,
-0.14508020877838135,
-0.2124660313129425,
-0.22009378671646118,
-0.401956707239151,
0.20357821881771088,
-0.09101779013872147,
0.020066430792212486,
-0.6570781469345093,
0.4010038673877716,
-0.3410230875015259,
-0.3425728678703308,
0.32220035791397095,
-0.7430412173271179,
-0.06788128614425659,
0.051757022738456726,
-0.025775106623768806,
0.2700183093547821,
0.1433562934398651,
0.1314169019460678,
-0.02830205298960209,
-0.5927207469940186,
-0.09280247241258621,
0.54326993227005,
0.008140669204294682,
-0.18442127108573914,
0.20738236606121063,
-0.12215495854616165,
0.07740572094917297,
-0.012301398441195488,
-0.1645781695842743,
0.981181263923645,
-0.03976608067750931,
-0.4285707175731659,
0.5039932131767273,
0.4312836229801178,
-0.006340679246932268,
-0.1476316601037979,
-0.04430588707327843,
0.6769213676452637,
0.006238433066755533,
0.3039814531803131,
0.30888989567756653,
-0.2081059068441391,
0.06089356541633606,
-0.8024845123291016,
-0.17950190603733063,
0.2847859263420105,
-0.8088927268981934,
-0.39207473397254944,
0.20889465510845184,
0.17347092926502228,
-0.18116240203380585,
-0.007117632310837507,
0.07798174768686295,
-0.6316697597503662,
0.25871410965919495,
-0.5584330558776855,
0.243146151304245,
-0.3007061183452606,
0.01794753409922123,
-0.13096539676189423,
0.06222999468445778,
-0.6088200807571411,
0.11966323852539062,
-0.08091773092746735,
-0.020781654864549637,
-0.07769221812486649,
0.24657239019870758,
-0.47627362608909607,
-0.30199703574180603,
-0.07446080446243286,
0.1238667219877243,
-0.1265842616558075,
0.13238051533699036,
0.38526618480682373,
0.009798398241400719,
0.7722485065460205,
0.26829689741134644,
0.06299248337745667,
0.3053351044654846,
-0.4284301996231079,
0.9572609066963196,
-0.27151772379875183,
-0.4454995095729828,
-0.34080830216407776,
0.407905250787735,
0.561610758304596,
-0.19857946038246155,
0.12083594501018524,
0.6786651611328125,
-0.44326433539390564,
0.196530282497406,
-0.2564184367656708,
-0.3408504128456116,
-0.2504281997680664,
0.5556429624557495,
-0.011440802365541458,
-0.3418952524662018,
-0.2316420078277588,
0.8429352641105652,
-0.07457750290632248,
0.42762038111686707,
-0.04100463539361954,
-0.09020821005105972,
0.3767516314983368,
0.36104825139045715,
-0.18528318405151367,
0.2761135399341583,
0.6808959245681763,
-0.3798774182796478,
-0.07095623761415482,
0.2509765326976776,
0.4890822470188141,
-0.31175240874290466,
0.2245410978794098,
0.6640873551368713,
-0.7853896021842957,
0.0027987982612103224,
0.012057311832904816,
0.31270021200180054,
-0.23873628675937653,
0.5291058421134949,
-0.09089627116918564,
-0.4368717074394226,
-0.38730430603027344,
0.008328152820467949,
0.35118475556373596,
-0.12132859230041504,
-0.2549636960029602,
-0.4465361535549164,
-0.36859068274497986,
-0.22755441069602966,
-0.24379676580429077,
-0.10739666223526001,
-0.32192572951316833,
-0.012272820807993412,
0.2295234501361847,
0.2912989854812622,
-0.16624142229557037,
0.33368024230003357,
-0.23856738209724426,
0.724119246006012,
0.2642727792263031,
-0.7174822092056274,
-0.1712580919265747,
-0.09026981890201569,
0.44714829325675964,
-0.4751797020435333,
-0.64189612865448,
-0.05365876853466034,
0.44754332304000854,
-0.48464304208755493,
-0.25181087851524353,
-0.1271791011095047,
-0.3746776580810547,
0.44917911291122437,
-0.08106084167957306,
0.05299406498670578,
-0.225455641746521,
0.05901919677853584,
-0.13486792147159576,
0.21231919527053833,
-0.24536988139152527,
-0.34288594126701355,
0.74397212266922,
0.5964561104774475,
0.058377135545015335,
-0.15923787653446198,
0.16374479234218597,
-0.7742490172386169,
-0.11403251439332962,
0.2811727523803711,
0.4619533121585846,
-0.11779038608074188,
0.07297534495592117,
0.347466379404068,
-0.4368704557418823,
0.0054933615028858185,
-0.24100196361541748,
-0.11927095800638199,
-0.5456739068031311,
0.1941983550786972,
0.4846484661102295,
-0.21503160893917084,
0.5176633596420288,
0.09567619115114212,
-0.2773118317127228,
0.04112880304455757,
0.3480791449546814,
-0.20835229754447937,
-0.4791947901248932,
-0.4095132350921631,
-0.5779595375061035,
-0.21954688429832458,
0.061612751334905624,
-0.42536041140556335,
-0.05794798582792282,
0.4926881492137909,
-0.7373061776161194,
-0.3126271367073059,
0.5136968493461609,
-0.025300191715359688,
-0.4169999361038208,
0.04598373919725418,
0.21439233422279358,
-0.2184368073940277,
0.07632111757993698,
0.2778637707233429,
-1.1856355667114258,
0.1009819433093071,
0.3840884864330292,
-0.3203794062137604,
-0.1037275493144989,
0.18822525441646576,
-0.07568732649087906,
-0.3723944127559662,
-0.5150563716888428,
-0.31301555037498474,
0.11317244917154312,
-0.372017502784729,
0.2209346741437912,
0.14330658316612244,
0.7529680728912354,
-0.4447070360183716,
-0.4077344238758087,
-0.05172605440020561,
0.300542950630188,
0.39408138394355774,
-0.21790564060211182,
-0.5821053385734558,
0.08133696019649506,
0.11093468964099884,
0.09899378567934036,
0.1394302099943161,
0.04371970519423485,
0.807813823223114,
-0.09653495252132416,
-0.16871625185012817,
-0.7580513954162598,
-0.02899814397096634,
0.10433655232191086,
-0.3139196038246155,
-0.24533279240131378,
-0.01867488957941532,
-0.252345472574234,
0.31102627515792847,
0.21876604855060577,
0.04174480587244034,
-0.5118135809898376,
0.2682760953903198,
-0.36278820037841797,
-0.02217167802155018,
0.06487156450748444,
0.3543420135974884,
0.6225976943969727,
0.06862302869558334,
0.0652528703212738,
-0.10946588218212128,
0.2935287058353424,
-0.25810086727142334,
0.0035042823292315006,
-0.19588704407215118,
-0.36537182331085205,
-0.2661208510398865,
-0.0841023176908493,
0.19461791217327118,
0.26532018184661865,
0.31753993034362793,
-0.25738516449928284,
-0.049803830683231354,
0.024360544979572296,
-0.3299378454685211,
0.0881093218922615,
-0.6179408431053162,
-0.015587437897920609,
0.28246182203292847,
0.3969169855117798,
0.3609042167663574,
0.12299616634845734,
-0.10741300135850906,
-0.324617475271225,
-0.7015895247459412,
0.5037097334861755,
0.014193414710462093,
-0.27814921736717224,
0.4864398241043091,
0.16822797060012817,
0.4895605146884918,
0.42686349153518677,
-0.2119339406490326,
-0.17617367208003998,
0.7004092335700989,
0.2101871222257614,
0.033015117049217224,
0.6334604620933533,
-0.23209726810455322,
-0.09017428755760193,
0.1368713229894638,
-0.23616886138916016,
0.5576601624488831,
0.37524354457855225,
-0.35291406512260437,
0.27432483434677124,
0.6954724788665771,
-0.2985626459121704,
-0.717232882976532,
0.6135393381118774,
-0.2835771441459656,
0.33686384558677673,
-0.12993161380290985,
0.34738656878471375,
0.5174188017845154,
0.9400535225868225,
-0.4245336949825287,
0.5740034580230713,
0.14054793119430542,
0.3941051959991455,
0.5988361239433289,
-0.37725940346717834,
-0.1361520141363144,
-0.024020882323384285,
0.5880532264709473,
0.5083427429199219,
-0.3801807165145874,
0.5569945573806763,
-0.05819099768996239,
0.13766615092754364,
0.2574250400066376,
0.30207929015159607,
-0.2587251365184784,
0.03277839347720146,
-0.015226254239678383,
-0.0587698295712471,
0.09435005486011505,
0.23862412571907043,
-0.09110470861196518,
0.0728200227022171,
0.23873792588710785,
-0.4832485318183899,
-0.45320597290992737,
0.5523827075958252,
0.5223020315170288,
0.4791632890701294,
-0.3180522620677948,
-0.034260109066963196,
-0.37555834650993347,
-0.5414678454399109,
0.14022426307201385,
0.12300453335046768,
-0.1432799994945526,
-0.27649083733558655,
-0.035003311932086945,
0.11436739563941956,
-0.5581664443016052,
0.16867174208164215,
0.08821317553520203,
-0.5943792462348938,
-0.19185742735862732,
0.36180379986763,
-0.20887871086597443,
0.42036935687065125,
0.056311458349227905,
0.5248217582702637,
-0.029624687507748604,
-0.5233318209648132,
0.12290458381175995,
-0.1405147761106491,
-0.123416967689991,
-0.15571092069149017,
0.5299534797668457,
0.2018408179283142,
0.22040219604969025,
-0.9845265746116638,
-0.25921428203582764,
0.20190469920635223,
0.33241894841194153,
0.1892365664243698,
-0.3979222774505615,
0.59365314245224,
0.47135522961616516,
0.21555648744106293,
0.19183789193630219,
0.3168725073337555,
-0.32458627223968506,
0.5003876686096191,
-0.3399142324924469,
0.6359013915061951,
-0.625145435333252,
0.20123128592967987,
-0.7188675403594971,
0.1684560328722,
0.8848426342010498,
0.24039232730865479,
-0.42433321475982666,
0.04222837835550308,
-0.10135555267333984,
0.14204993844032288,
0.2618172764778137,
-0.3220548629760742,
-0.05516837164759636,
-0.5632869005203247,
-0.5655097365379333,
-0.43826204538345337,
0.8118357062339783,
-0.14604678750038147,
0.18485037982463837,
-0.1894969940185547,
0.19670185446739197,
0.45215079188346863,
-0.2908118963241577,
0.38304364681243896,
-0.026105085387825966,
-0.19243888556957245,
-0.6607383489608765,
0.7622839212417603,
-0.4014137387275696,
0.3690972626209259,
-0.3580557703971863,
-0.061442337930202484,
0.4303427040576935,
-0.38539832830429077,
-0.11085031926631927,
-0.4620054364204407,
0.015849685296416283,
0.5173534154891968,
-0.19149132072925568,
0.4384176433086395,
-0.4340968132019043,
-0.07842850685119629,
-0.5759482383728027,
0.3399435877799988,
0.04202335327863693,
-0.4070950448513031,
-0.1952335089445114,
-0.2980561852455139,
-0.8731191754341125,
0.038901615887880325,
-0.24371238052845,
-0.33418208360671997,
-0.22108513116836548,
-0.2829429507255554
] |
BACKGROUND: Several methodological approaches have been used to estimate distance in health service research. In this study, focusing on cardiac catheterization services, Euclidean, Manhattan, and the less widely known Minkowski distance metrics are used to estimate distances from patient residence to hospital. Distance metrics typically produce less accurate estimates than actual measurements, but each metric provides a single model of travel over a given network. Therefore, distance metrics, unlike actual measurements, can be directly used in spatial analytical modeling. Euclidean distance is most often used, but unlikely the most appropriate metric. Minkowski distance is a more promising method. Distances estimated with each metric are contrasted with road distance and travel time measurements, and an optimized Minkowski distance is implemented in spatial analytical modeling. METHODS: Road distance and travel time are calculated from the postal code of residence of each patient undergoing cardiac catheterization to the pertinent hospital. The Minkowski metric is optimized, to approximate travel time and road distance, respectively. Distance estimates and distance measurements are then compared using descriptive statistics and visual mapping methods. The optimized Minkowski metric is implemented, via the spatial weight matrix, in a spatial regression model identifying socio-economic factors significantly associated with cardiac catheterization. RESULTS: The Minkowski coefficient that best approximates road distance is 1.54; 1.31 best approximates travel time. The latter is also a good predictor of road distance, thus providing the best single model of travel from patient's residence to hospital. The Euclidean metric and the optimal Minkowski metric are alternatively implemented in the regression model, and the results compared. The Minkowski method produces more reliable results than the traditional Euclidean metric. CONCLUSION: Road distance and travel time measurements are the most accurate estimates, but cannot be directly implemented in spatial analytical modeling. Euclidean distance tends to underestimate road distance and travel time; Manhattan distance tends to overestimate both. The optimized Minkowski distance partially overcomes their shortcomings; it provides a single model of travel over the network. The method is flexible, suitable for analytical modeling, and more accurate than the traditional metrics; its use ultimately increases the reliability of spatial analytical models. | [
0.012570863589644432,
0.015623219311237335,
-0.018840312957763672,
0.024781495332717896,
0.0019255434162914753,
-0.022055819630622864,
0.013362509198486805,
-0.03320005536079407,
-0.012754480354487896,
-0.02320285141468048,
-0.011143098585307598,
0.013362593948841095,
-0.00526958703994751,
0.022149357944726944,
-0.021888479590415955,
0.02107434906065464,
-0.00030711712315678596,
0.01490903738886118,
0.012138983234763145,
-0.04608900099992752,
0.016737664118409157,
0.008126077242195606,
0.011756790801882744,
0.01736731082201004,
-0.001360462512820959,
0.01571473851799965,
-0.02035343274474144,
-0.02603233978152275,
0.03367128595709801,
-0.002665432170033455,
-0.029674313962459564,
-0.02115887776017189,
0.045861005783081055,
0.002190515398979187,
0.005786961875855923,
-0.028671657666563988,
-0.006225631106644869,
0.02692743018269539,
-0.05944628268480301,
-0.00398637680336833,
0.00927843526005745,
-0.006671731360256672,
-0.00023291923571377993,
0.01508417259901762,
-0.011018216609954834,
0.015879197046160698,
-0.007780336309224367,
-0.005140600726008415,
-0.010826993733644485,
0.01088373176753521,
-0.028948888182640076,
-0.0031722718849778175,
-0.0020008401479572058,
-0.025509286671876907,
-0.007871237583458424,
-0.027292408049106598,
0.020049938932061195,
0.008876828476786613,
-0.030024107545614243,
0.0023951036855578423,
-0.0038428795523941517,
0.016547594219446182,
0.005295582115650177,
-0.05037517845630646,
0.0018148105591535568,
-0.06640130281448364,
0.006500326097011566,
-0.024554871022701263,
0.028254834935069084,
-0.0030886351596564054,
-0.0014656176790595055,
0.007055912632495165,
-0.0106881782412529,
-0.04329262301325798,
0.025344206020236015,
0.032017678022384644,
-0.012716738507151604,
0.019587429240345955,
0.007601458579301834,
0.004802963230758905,
-0.016932183876633644,
-0.012142614461481571,
-0.024737786501646042,
0.039711546152830124,
0.024875283241271973,
-0.0016841785982251167,
-0.010244742967188358,
0.028906552121043205,
0.02492176741361618,
0.005791536532342434,
-0.00338126253336668,
-0.02236093208193779,
-0.001011475920677185,
-0.01928821951150894,
0.006523534655570984,
0.026468826457858086,
-0.008068467490375042,
0.04545440152287483,
0.012912333942949772,
-0.019235607236623764,
-0.014954578131437302,
-0.00450470857322216,
0.02384038269519806,
-0.011762105859816074,
-0.051737599074840546,
0.01782126910984516,
-0.03222509101033211,
0.022448020055890083,
-0.04456399381160736,
0.007376379333436489,
-0.002571296878159046,
-0.0017493348568677902,
0.001444132998585701,
0.004822656512260437,
0.01782372035086155,
0.010021563619375229,
0.004877571947872639,
-0.02678682468831539,
0.010715406388044357,
-0.02082865685224533,
0.04876217991113663,
0.000611109659075737,
0.00842677429318428,
-0.03004453331232071,
0.00023763772333040833,
-0.010934000834822655,
-0.0410628616809845,
-0.019944338127970695,
-0.009079951792955399,
0.007261048071086407,
-0.011880351230502129,
0.011294790543615818,
0.0464545302093029,
-0.0011593662202358246,
-0.01169528067111969,
-0.00878195371478796,
-0.0010542761301621795,
0.008153656497597694,
0.00286656990647316,
-0.035644806921482086,
0.0046696774661540985,
0.013181814923882484,
0.0053109233267605305,
0.005452890880405903,
0.014712361618876457,
-0.003064784687012434,
0.013315707445144653,
0.02330537512898445,
-0.0051805078983306885,
0.004562565591186285,
-0.006996043957769871,
-0.02161029353737831,
-0.014106322079896927,
-0.012605112046003342,
0.009631486609578133,
-0.003906448371708393,
-0.01682046428322792,
0.003907504491508007,
-0.0005837532225996256,
-0.001593929249793291,
-0.011857962235808372,
-0.026556596159934998,
0.008449879474937916,
0.01121445931494236,
0.00946100801229477,
0.03354574739933014,
0.023336136713624,
0.00599257368594408,
-0.01032840646803379,
0.005652628373354673,
-0.02380656823515892,
0.006354097276926041,
-0.00521080382168293,
0.012269431725144386,
-0.012809287756681442,
-0.01118136290460825,
-0.010745532810688019,
0.013002222403883934,
-0.008056807331740856,
0.06640145182609558,
0.009006178937852383,
-0.00942640658468008,
0.005699858069419861,
0.009786576963961124,
-0.009716812521219254,
-0.009062759578227997,
0.019389797002077103,
-0.0009762052213773131,
0.015936682000756264,
0.007961109280586243,
-0.05686231702566147,
-0.006379668600857258,
0.021200479939579964,
0.00806492194533348,
-0.014703046530485153,
0.004606760106980801,
0.013849345035851002,
0.008265831507742405,
-0.011128688231110573,
-0.047095511108636856,
-0.004997207783162594,
-0.00717470096424222,
0.0016849569510668516,
0.023310184478759766,
0.043264128267765045,
0.026531493291258812,
-0.0019038836471736431,
-0.00594410439953208,
-0.0034126718528568745,
0.026180237531661987,
0.0005888036685064435,
0.007179534528404474,
0.0003314556088298559,
-0.0058706882409751415,
-0.008418150246143341,
0.006975584663450718,
0.004040463827550411,
-0.020415788516402245,
0.018379785120487213,
-0.012766852974891663,
0.0035370136611163616,
-0.002815376501530409,
-0.019001035019755363,
0.006887766532599926,
-0.004295894410461187,
-0.00800770241767168,
-0.0013276326935738325,
0.013759136199951172,
0.00109447306022048,
0.011072794906795025,
-0.013068635016679764,
-0.01590379886329174,
-0.015476686879992485,
-0.002782829338684678,
0.02162747085094452,
0.008030323311686516,
0.013150832615792751,
-0.035628966987133026,
0.0115503603592515,
-0.010377739556133747,
-0.006311060860753059,
-0.0026305997744202614,
0.01490342989563942,
0.014906354248523712,
-0.007882784120738506,
-0.02228747308254242,
-0.008524651639163494,
-0.001339118229225278,
-0.002807412762194872,
0.002605593763291836,
0.00774996355175972,
-0.03509166091680527,
0.015839124098420143,
0.007592539303004742,
0.026095442473888397,
-0.013983339071273804,
0.007432979065924883,
0.016946714371442795,
0.02704608254134655,
-0.031966712325811386,
0.00225930311717093,
0.009539658203721046,
-0.01826527714729309,
0.028407448902726173,
0.004526016302406788,
-0.017112750560045242,
-0.014465747401118279,
0.04056757315993309,
0.01063155010342598,
-0.013711446896195412,
0.004510409198701382,
-0.01667969673871994,
-0.010390031151473522,
-0.0806194394826889,
-0.017351819202303886,
0.02661265805363655,
-0.013040337711572647,
0.008553669787943363,
0.008745943196117878,
0.005004893057048321,
0.013473832048475742,
-0.011464713141322136,
-0.015799107030034065,
0.01579667627811432,
-0.02920600399374962,
-0.020291291177272797,
0.018851380795240402,
-0.01755167916417122,
-0.007242344785481691,
0.012800184078514576,
0.013814751990139484,
0.012225757353007793,
0.012163020670413971,
0.003953823819756508,
-0.04242856800556183,
0.0012141726911067963,
0.03631114959716797,
0.01968604139983654,
0.02651897259056568,
0.02776653692126274,
-0.008324704132974148,
-0.01570175588130951,
0.008199227973818779,
0.01867767795920372,
-0.023204851895570755,
-0.020436344668269157,
-0.009341654367744923,
0.006285225041210651,
-0.008562710136175156,
0.010358905419707298,
-0.0020338306203484535,
0.005592194851487875,
0.008799893781542778,
0.01968528889119625,
0.025806661695241928,
0.012594473548233509,
0.0017900513485074043,
0.006064638961106539,
0.004020253662019968,
0.03612465038895607,
-0.03477032482624054,
0.016945749521255493,
-0.013518938794732094,
0.02182132937014103,
-0.014827067032456398,
0.0022531584836542606,
0.01328299194574356,
-0.02619822323322296,
-0.016718361526727676,
-0.014516135677695274,
-0.006377934478223324,
-0.01403895579278469,
-0.006010247394442558,
-0.009628450497984886,
-0.05213620886206627,
-0.022035952657461166,
0.0022501787170767784,
0.020151477307081223,
-0.016287267208099365,
0.011302715167403221,
-0.007918630726635456,
-0.011183875612914562,
-0.007931445725262165,
0.007350321393460035,
-0.015726856887340546,
0.020488526672124863,
-0.00275705149397254,
-0.0019378140568733215,
-0.01308507937937975,
-0.01417759619653225,
-0.006429313216358423,
-0.005126034375280142,
-0.012656277976930141,
0.0008282521739602089,
0.01583634689450264,
0.007585776038467884,
-0.011948149651288986,
-0.010611992329359055,
0.030123569071292877,
0.00879246462136507,
-0.015938889235258102,
0.001180489081889391,
-0.02193034254014492,
0.0024729312863200903,
-0.023544255644083023,
-0.0010875475127249956,
0.007319352589547634,
-0.01402227208018303,
0.0022259503602981567,
0.027169425040483475,
-0.021512510254979134,
-0.00036286888644099236,
0.011792592704296112,
0.010636767372488976,
-0.0022234953939914703,
-0.008751346729695797,
-0.015450196340680122,
-0.031284794211387634,
0.013165464624762535,
0.004170956090092659,
0.011196923442184925,
0.0259786956012249,
-0.010867524892091751,
-0.031456317752599716,
-0.014526156708598137,
-0.009503103792667389,
0.0027109861839562654,
0.013441392220556736,
-0.01556612178683281,
0.0204901285469532,
0.021078772842884064,
0.07166939973831177,
0.026029158383607864,
0.028939947485923767,
-0.015425894409418106,
-0.014437656849622726,
-0.013258613646030426,
-0.00957865733653307,
-0.002031660173088312,
-0.023837238550186157,
0.019188301637768745,
0.01516777090728283,
0.03323500603437424,
0.020049605518579483,
0.01797889731824398,
-0.019298747181892395,
-0.0035048755817115307,
0.007989597506821156,
-0.013285420835018158,
-0.03351058065891266,
-0.02824498899281025,
0.019623029977083206,
0.017513327300548553,
-0.04875800013542175,
0.013456552289426327,
-0.008794187568128109,
-0.037974901497364044,
0.007550481241196394,
-0.013851461000740528,
-0.019955160096287727,
0.0016490487614646554,
0.007284729275852442,
0.022624200209975243,
-0.005049034021794796,
-0.005860002711415291,
0.00903141126036644,
0.007353327237069607,
0.013530280441045761,
-0.0023796032182872295,
0.005296194925904274,
0.01567375287413597,
0.033409420400857925,
-0.015310192480683327,
0.03274517133831978,
0.014952817931771278,
0.02970781922340393,
-0.026285681873559952,
-0.030856357887387276,
-0.008274388499557972,
-0.010756976902484894,
0.008527683094143867,
-0.013092655688524246,
0.021223273128271103,
0.01206265203654766,
0.02282445877790451,
0.0012528449296951294,
0.00919704046100378,
-0.036298271268606186,
-0.003922599367797375,
0.020668648183345795,
0.006437074858695269,
-0.007349719759076834,
-0.011953577399253845,
0.02704227715730667,
-0.03361443430185318,
-0.014800723642110825,
0.005746784619987011,
-0.015979260206222534,
-0.0274509247392416,
-0.0033047879114747047,
0.009202228859066963,
0.014973518438637257,
-0.04099861532449722,
0.007733371574431658,
-0.009682230651378632,
0.028671802952885628,
-0.02899502031505108,
0.011661548167467117,
-0.009110351093113422,
-0.019988272339105606,
-0.00809489842504263,
-0.00416509248316288,
0.025257473811507225,
0.003285961225628853,
0.022356441244482994,
-0.001186263281852007,
0.016072876751422882,
0.02305353432893753,
-0.07414190471172333,
-0.005763836670666933,
0.005505239591002464,
-0.010470918379724026,
-0.049033015966415405,
0.01727874204516411,
-0.017017245292663574,
-0.0011239757295697927,
0.0545615516602993,
-0.010499297641217709,
-0.015171979553997517,
0.0023899455554783344,
-0.04518308490514755,
-0.01149381697177887,
0.015191630460321903,
-0.013652818277478218,
-0.029936525970697403,
0.0027545287739485502,
0.0018353606574237347,
0.019581303000450134,
0.013687372207641602,
0.04386796057224274,
-0.03243791684508324,
-0.013165008276700974,
-0.009030924178659916,
-0.08071112632751465,
0.005737274885177612,
0.006547400262206793,
-0.016622504219412804,
-0.0005870554596185684,
-0.01965942420065403,
0.02574675716459751,
-0.009077239781618118,
-0.0014996048994362354,
-0.01512568723410368,
0.0020605819299817085,
0.015192871913313866,
0.001705750823020935,
0.013908184133470058,
0.008592264726758003,
-0.004394487012177706,
0.026258094236254692,
-0.024823429062962532,
-0.02739252895116806,
0.00245209620334208,
-0.0011484865099191666,
0.022467926144599915,
-0.010715242475271225,
-0.0006500810850411654,
-0.00996356550604105,
-0.024715354666113853,
0.02234724536538124,
0.01555304042994976,
0.0007561949314549565,
0.015754420310258865,
0.010500800795853138,
0.006591190118342638,
-0.005549257155507803,
-0.015840813517570496,
-0.012208487838506699,
-0.013153420761227608,
0.007151437923312187,
-0.030231356620788574,
-0.027677621692419052,
-0.0035351403057575226,
-0.011154916137456894,
-0.005723539274185896,
0.006941577419638634,
-0.030896008014678955,
-0.01602248102426529,
-0.02554488554596901,
0.005275201052427292,
-0.013914276845753193,
0.0024948078207671642,
0.0033433858770877123,
0.008923445828258991,
0.015847912058234215,
0.04240591824054718,
0.011301826685667038,
-0.00027805380523204803,
0.027976274490356445,
-0.00949669536203146,
-0.00003384228330105543,
0.03686222434043884,
-0.0018529933877289295,
-0.001903991331346333,
0.037109941244125366,
0.007461933884769678,
0.07133378088474274,
-0.026051707565784454,
0.013138714246451855,
0.0154379578307271,
-0.03229493275284767,
0.000017355603631585836,
-0.008676256984472275,
-0.008800903335213661,
-0.02750326320528984,
0.008478802628815174,
-0.01584148406982422,
-0.001797528937458992,
-0.015383118763566017,
0.009180095046758652,
0.005812883377075195,
-0.00003485940396785736,
0.00716804526746273,
0.0336899533867836,
0.012096376158297062,
-0.04754362627863884,
0.047556035220623016,
0.006730793043971062,
-0.052200887352228165,
0.014815453439950943,
0.02952798269689083,
-0.010956218466162682,
0.021266832947731018,
0.007005833089351654,
0.011744477786123753,
0.0024600629694759846,
-0.012321783229708672,
0.028318071737885475,
0.009653961285948753,
-0.024597564712166786,
0.03859417885541916,
-0.004583311732858419,
0.0038157314993441105,
0.0012250342406332493,
-0.004257068503648043,
-0.020367637276649475,
0.0009411084465682507,
-0.030483391135931015,
-0.004233908839523792,
-0.00908780749887228,
0.00015060324221849442,
0.033606596291065216,
-0.00024153967387974262,
-0.002128923311829567,
0.001347959041595459,
0.006212489679455757,
-0.04493892565369606,
-0.005120980087667704,
-0.015136288478970528,
-0.006327108014374971,
0.0005648168735206127,
-0.0075660040602087975,
-0.012261772528290749,
0.017322909086942673,
0.030006717890501022,
0.008477877825498581,
0.008048021234571934,
-0.014415339566767216,
-0.007886684499680996,
0.0003378374967724085,
0.019462520256638527,
0.029841840267181396,
-0.0012628808617591858,
-0.009319251403212547,
0.061021484434604645,
0.014906615950167179,
-0.012241588905453682,
0.0199015773832798,
0.007323324680328369,
-0.007547519635409117,
-0.0028445690404623747,
-0.026550758630037308,
-0.01072042528539896,
-0.00853819027543068,
0.02355942502617836,
0.00906885601580143,
-0.00759733933955431,
0.006427831947803497,
0.019650466740131378,
-0.003807056462392211,
-0.04794517904520035,
0.03152714669704437,
0.008422312326729298,
0.016840219497680664,
-0.016153696924448013,
0.009576557204127312,
0.001101099420338869,
0.005367741454392672,
0.001591188833117485,
-0.00821462832391262,
0.011389598250389099,
0.036209579557180405,
-0.017406510189175606,
0.006704675033688545,
0.009132015518844128,
0.004607144743204117,
0.027424564585089684,
0.0075249625369906425,
-0.0063142357394099236,
-0.007153424900025129,
-0.027513008564710617,
-0.022931016981601715,
-0.02732454612851143,
0.014579893089830875,
-0.015816546976566315,
-0.01244264841079712,
-0.03205704316496849,
0.005170689430087805,
-0.001798097975552082,
-0.005433696322143078,
-0.0053557297214865685,
-0.021932614967226982,
-0.017183052375912666,
-0.01747421734035015,
0.00692540779709816,
-0.008866572752594948,
0.010965163819491863,
0.008726515807211399,
-0.007973597384989262,
0.03771378472447395,
0.025486087426543236,
-0.032039012759923935,
-0.006100814323872328,
0.014411778189241886,
-0.006248096004128456,
-0.012974328361451626,
0.011913440190255642,
0.029027458280324936,
0.01014125719666481,
0.008196557871997356,
-0.000588988303206861,
-0.04390043020248413,
0.004768729209899902,
-0.006038994528353214,
-0.0045347497798502445,
0.032215896993875504,
0.035682521760463715,
-0.00677903275936842,
0.002941732294857502,
-0.013092885725200176,
0.008099576458334923,
0.019097737967967987,
-0.020268067717552185,
0.04046809673309326,
0.00960283912718296,
0.0015130613464862108,
-0.017106251791119576,
0.026388350874185562,
0.005479923449456692,
-0.006396661512553692,
-0.007968672551214695,
0.01661692000925541,
0.009008984081447124,
0.009031880646944046,
-0.017169907689094543,
0.019134392961859703,
0.0015287511050701141,
-0.0002834615297615528,
0.008271928876638412,
0.016433507204055786,
0.0030599450692534447,
-0.0050232140347361565,
-0.002931693335995078,
-0.010036293417215347,
-0.010544558987021446,
-0.02933073788881302,
-0.0007601955439895391,
-0.02540941908955574,
-0.029721155762672424,
0.02466329000890255,
-0.02395692840218544,
-0.012743191793560982,
0.01882772333920002,
0.0031267539598047733,
-0.029707981273531914,
-0.009885888546705246,
0.001703394460491836,
-0.006453505717217922,
0.0025130105204880238,
-0.00999598391354084,
0.010676652193069458,
0.004991808440536261,
-0.014023834839463234,
-0.007412446662783623,
0.0321650430560112,
-0.02135072648525238,
-0.0011181659065186977,
-0.0069926418364048,
-0.019001629203557968,
0.0057749068364501,
-0.015861457213759422,
-0.008656383492052555,
-0.010476653464138508,
-0.010808699764311314,
0.0009898397838696837,
0.007995161227881908,
-0.0033458657562732697,
-0.008912423625588417
] | [
0.38002458214759827,
-0.2250245362520218,
0.36767488718032837,
0.2540878355503082,
0.24287346005439758,
0.4294082522392273,
-0.060629431158304214,
0.039812278002500534,
-0.06156354397535324,
-0.8297836780548096,
0.006678350735455751,
0.21849268674850464,
0.1265859752893448,
0.28328368067741394,
-0.13673770427703857,
0.6030106544494629,
0.6242712140083313,
0.4423642158508301,
-0.21062268316745758,
-0.340371310710907,
-0.5416787266731262,
-0.029266130179166794,
0.29319873452186584,
-0.14817559719085693,
-0.07500416040420532,
-0.10625488311052322,
0.03715473413467407,
0.06534047424793243,
-0.007137006614357233,
-0.08774638921022415,
0.03939887508749962,
0.3965788781642914,
-0.326306015253067,
0.06529244035482407,
0.6228264570236206,
-0.3222317099571228,
0.2984241247177124,
0.13362321257591248,
0.13651223480701447,
-0.5946524143218994,
-0.3309863209724426,
-0.10812007635831833,
-0.0035551057662814856,
0.42246752977371216,
-0.08929608017206192,
-0.7173147797584534,
-1.4647512435913086,
0.05386152118444443,
-0.5670981407165527,
0.08060761541128159,
0.2217227667570114,
0.293018639087677,
0.4766480028629303,
0.7393286228179932,
-0.24504375457763672,
0.16470244526863098,
0.19678163528442383,
-0.12479332834482193,
0.49650296568870544,
-0.5969701409339905,
0.45817384123802185,
-0.04021493345499039,
-0.0608518049120903,
0.33172112703323364,
0.08464164286851883,
0.27875733375549316,
0.4947720468044281,
-0.44745832681655884,
0.047073617577552795,
-0.2951361835002899,
-0.1033308133482933,
-0.19505912065505981,
-0.17037956416606903,
0.4824180603027344,
-0.48508530855178833,
0.26385706663131714,
0.0669744685292244,
-0.26477688550949097,
0.1129811704158783,
-0.30754828453063965,
-0.14314480125904083,
-0.16248410940170288,
0.03341709449887276,
-0.3281659781932831,
0.4212788939476013,
-0.02497202903032303,
-0.20819056034088135,
0.30066776275634766,
-0.500313401222229,
0.45715487003326416,
0.12489864975214005,
-0.48299458622932434,
0.15382398664951324,
0.415183961391449,
0.16766679286956787,
0.2051389366388321,
0.6925581693649292,
-0.5303047895431519,
0.1387980878353119,
0.08632747828960419,
-0.34949585795402527,
-0.28341808915138245,
0.33130645751953125,
-0.21091681718826294,
-0.25710657238960266,
-0.6564570665359497,
0.053387973457574844,
0.18143588304519653,
-0.2606651484966278,
0.285146564245224,
-0.68476402759552,
0.13254466652870178,
0.05528753623366356,
-0.12229947000741959,
-0.32031023502349854,
-0.26429393887519836,
0.0920596495270729,
-0.1609460562467575,
-0.2243376523256302,
0.09114130586385727,
-0.5821131467819214,
0.8222169280052185,
-0.24284125864505768,
-0.0860079750418663,
0.2895326614379883,
0.25991344451904297,
0.8930063247680664,
0.2086770087480545,
-0.322805255651474,
0.3068081736564636,
0.0014472114853560925,
0.5422688722610474,
-0.08985738456249237,
0.08255080133676529,
0.1042662113904953,
-0.34545257687568665,
0.37458452582359314,
0.29336416721343994,
-0.08143996447324753,
-0.03839700296521187,
-0.11288231611251831,
-0.7003294825553894,
0.0734376609325409,
-0.02003050409257412,
0.475536584854126,
-0.6552334427833557,
0.0907011479139328,
-0.6516826152801514,
0.05857205390930176,
-0.18521767854690552,
0.00353784067556262,
0.5743598341941833,
-0.510043203830719,
-0.2736685574054718,
0.014173311181366444,
0.5490671396255493,
0.1020735427737236,
-0.00905472133308649,
-0.18046462535858154,
0.08163237571716309,
0.04798233509063721,
0.6584200263023376,
-0.4584159851074219,
-0.43332067131996155,
0.11992841958999634,
-0.3548811972141266,
0.35238224267959595,
0.3787756562232971,
-0.14745526015758514,
0.499647855758667,
-0.1181187704205513,
-0.2986432909965515,
-0.13518287241458893,
-0.5205545425415039,
-0.18431250751018524,
0.6945262551307678,
0.4688408374786377,
-0.02609274350106716,
0.2564356029033661,
0.016715561971068382,
-0.5454363822937012,
0.5713077187538147,
0.2318078577518463,
-0.5514016151428223,
0.23916994035243988,
-0.11531016230583191,
0.39370501041412354,
-0.04281735047698021,
-0.39651453495025635,
-0.4780609607696533,
-0.11636708676815033,
-0.7764659523963928,
0.23594161868095398,
-0.8445295095443726,
1.1079953908920288,
-0.45358359813690186,
-0.023310178890824318,
1.0224889516830444,
-0.40220433473587036,
0.02005103975534439,
-0.04108106717467308,
0.07269042730331421,
0.37549301981925964,
0.07644150406122208,
-0.452879935503006,
0.035584695637226105,
0.15925565361976624,
-0.2553369104862213,
-0.2708624005317688,
-0.16283126175403595,
0.8477575778961182,
-0.2490280419588089,
-0.5780034065246582,
-0.17784540355205536,
0.10462202876806259,
-0.00024389011377934366,
-0.25990059971809387,
0.20206965506076813,
-0.056641869246959686,
0.1865086853504181,
0.9246339797973633,
-0.591589629650116,
0.2951107323169708,
0.33111438155174255,
0.04898158833384514,
0.3916637599468231,
0.5410939455032349,
0.6101356148719788,
0.46840932965278625,
-0.4670431911945343,
0.15012036263942719,
-0.04123594984412193,
-0.12498590350151062,
-0.699666440486908,
-0.6169787645339966,
-0.1651960164308548,
0.28296905755996704,
-0.31202396750450134,
0.23880815505981445,
-0.46160444617271423,
-0.23241031169891357,
0.2594556212425232,
-0.28767821192741394,
0.19813914597034454,
0.16572275757789612,
-0.6176701784133911,
-0.4666842520236969,
-0.30888423323631287,
-0.2814028561115265,
0.0848371610045433,
-0.12067852169275284,
0.34819185733795166,
0.023379072546958923,
-0.1997995674610138,
0.37949877977371216,
-0.05932997167110443,
0.2807452082633972,
0.11054433137178421,
0.26142844557762146,
-0.14056232571601868,
0.09540002048015594,
0.5331900715827942,
0.42038494348526,
0.12060990184545517,
-0.34176328778266907,
-0.40604862570762634,
-0.8460108637809753,
-0.7927924990653992,
0.8227646946907043,
0.5488861799240112,
0.08982844650745392,
0.17589595913887024,
-0.6036863923072815,
0.0680161789059639,
-0.3664465546607971,
-0.8791995644569397,
0.5412097573280334,
0.6689149737358093,
-0.5609659552574158,
-0.14426018297672272,
0.2211625874042511,
0.35487574338912964,
1.0076831579208374,
-0.1597512811422348,
-0.10872311890125275,
-0.6116268634796143,
0.12786513566970825,
0.16819527745246887,
-0.17878684401512146,
0.1633906066417694,
-0.4808427691459656,
0.7313998937606812,
-0.17134183645248413,
-0.29441118240356445,
0.5001868009567261,
0.449105829000473,
0.4092058539390564,
-0.2824365496635437,
0.1280377060174942,
-0.35049664974212646,
-0.13376815617084503,
0.4035843312740326,
0.2997070550918579,
-0.2897006869316101,
-0.12673498690128326,
-0.2547714114189148,
-0.5784369111061096,
0.18214544653892517,
-6.005011081695557,
0.268258661031723,
-0.29835066199302673,
-0.22736716270446777,
-0.2368851751089096,
-0.10239149630069733,
0.7764245271682739,
-0.19046518206596375,
-0.22558890283107758,
-0.29406389594078064,
0.33323851227760315,
0.18081815540790558,
0.4248933792114258,
0.33690857887268066,
0.45483115315437317,
-0.08170771598815918,
0.04754732921719551,
0.27060186862945557,
0.23409338295459747,
0.3307839035987854,
-0.17139841616153717,
-0.24744342267513275,
0.256111204624176,
0.5328898429870605,
0.5388118624687195,
0.30122166872024536,
-0.8052762746810913,
0.4843348264694214,
-0.3280678391456604,
-0.17893941700458527,
0.4148542284965515,
-0.3206779658794403,
0.09141545742750168,
-0.22576752305030823,
0.5980417728424072,
0.005171807948499918,
0.12295336276292801,
-0.10164820402860641,
0.4993038475513458,
-0.3018640875816345,
0.09057196229696274,
0.8817988634109497,
-0.03371059522032738,
-0.16739173233509064,
-0.0738745778799057,
-0.06855960190296173,
0.03184570372104645,
0.5483948588371277,
-0.2639021575450897,
0.8091505169868469,
-0.20767611265182495,
0.2393474280834198,
-0.1080143004655838,
0.2473272830247879,
-0.09196601063013077,
-0.2170625627040863,
-0.007110922131687403,
0.539664089679718,
-0.3989728093147278,
0.22561824321746826,
0.24787643551826477,
-0.2836507260799408,
0.14098097383975983,
-0.7712042927742004,
-0.17896303534507751,
0.02999955415725708,
-0.923229455947876,
-0.6910715699195862,
0.0022410035599023104,
0.1051856204867363,
-0.4587034583091736,
-0.08827997744083405,
0.3754427134990692,
-0.5025254487991333,
0.019745297729969025,
-0.5182879567146301,
0.2514978349208832,
0.08412272483110428,
0.21875479817390442,
0.0017604760359972715,
-0.1373993456363678,
-0.20152243971824646,
0.1033719927072525,
0.020231785252690315,
-0.0009591865236870944,
-0.048361293971538544,
-0.3003692626953125,
-0.1638460010290146,
-0.3856966197490692,
0.0011775409802794456,
0.7580509185791016,
-0.6440303921699524,
0.41327184438705444,
-0.1617734432220459,
0.33280277252197266,
0.3383682072162628,
0.343245267868042,
0.005369407590478659,
0.3950081467628479,
-0.3951718807220459,
0.8736793398857117,
-0.16558034718036652,
-0.35876357555389404,
-0.8340155482292175,
0.04794367402791977,
-0.20056313276290894,
-0.8872168064117432,
0.5901288390159607,
0.7090019583702087,
-0.7161652445793152,
0.02005608193576336,
0.026672309264540672,
-0.12824302911758423,
-0.49380743503570557,
0.25691989064216614,
-0.4906778633594513,
-0.4164327085018158,
-0.16865454614162445,
0.5176450610160828,
-0.06648015230894089,
0.09776922315359116,
0.0572701059281826,
0.22809652984142303,
0.06808435171842575,
0.4856882095336914,
-0.07880353927612305,
-0.08884086459875107,
0.6013829112052917,
-0.529890775680542,
0.12460336834192276,
0.5116199254989624,
0.8666538000106812,
-0.12528304755687714,
0.1590842306613922,
-0.10506311804056168,
-0.5097824931144714,
-0.16245011985301971,
0.36147409677505493,
0.5958845019340515,
-0.10222730040550232,
0.24998372793197632,
-0.02031160332262516,
-0.4279710054397583,
0.059800583869218826,
0.4199340045452118,
0.08838941156864166,
-0.4789397120475769,
-0.1516018807888031,
0.0645555704832077,
-0.06792482733726501,
-0.06395118683576584,
0.08983834832906723,
0.2798260748386383,
0.0902307853102684,
0.038575343787670135,
-0.27188122272491455,
0.35819077491760254,
-0.14348118007183075,
-0.4685198962688446,
-0.326272189617157,
0.4685404896736145,
0.4404852092266083,
-1.1176340579986572,
-0.14964348077774048,
0.007727110758423805,
-0.2720843553543091,
-0.2971416115760803,
-0.44543570280075073,
0.00442509725689888,
0.25597333908081055,
0.35218819975852966,
-0.6120120882987976,
-0.32495880126953125,
-0.34561672806739807,
-0.1669766753911972,
0.5262950658798218,
0.02778884582221508,
0.48994094133377075,
0.013216922990977764,
0.13227972388267517,
0.2480076402425766,
-0.31119775772094727,
-0.13801270723342896,
-0.014419591054320335,
0.7839072346687317,
0.33213484287261963,
0.27253738045692444,
-0.01955558732151985,
-0.48608988523483276,
-0.1722501665353775,
0.37676259875297546,
0.0001514326431788504,
0.19391360878944397,
-0.01662343740463257,
0.21396173536777496,
-0.20758025348186493,
0.29062870144844055,
0.48607519268989563,
-0.2656465470790863,
0.11978156864643097,
-0.03973124548792839,
0.47631052136421204,
-0.6690433025360107,
0.5782825946807861,
0.1996534764766693,
-0.42575526237487793,
0.28923550248146057,
0.270220011472702,
0.030797462910413742,
-0.15329334139823914,
-1.049142599105835,
-0.4275011718273163,
-0.3553626537322998,
0.02018900401890278,
-0.4705374538898468,
0.2607433497905731,
0.10742442309856415,
-0.25143104791641235,
-0.37242764234542847,
-0.05344640091061592,
0.49857744574546814,
0.07816280424594879,
-0.6486283540725708,
-0.1391047239303589,
-0.1199895590543747,
0.12420213967561722,
0.2763650417327881,
-0.767105758190155,
-0.1460566520690918,
0.1300787776708603,
-0.7257822751998901,
-0.118711918592453,
0.1387110948562622,
-0.04064370319247246,
-0.49051839113235474,
-0.1972459852695465,
-0.2137889862060547,
-0.2603418231010437,
0.054614290595054626,
0.17645889520645142,
0.23007968068122864,
0.757646918296814,
-0.24199101328849792,
-0.6479300260543823,
0.04063927009701729,
0.8283555507659912,
0.5098535418510437,
-0.8404241800308228,
-0.4183800220489502,
-0.12547968327999115,
0.36825454235076904,
-0.8363769054412842,
-0.16976462304592133,
-0.2423810511827469,
-0.055195119231939316,
0.05799231678247452,
-0.4674820005893707,
-0.18786583840847015,
0.04000232368707657,
0.2498544603586197,
-0.20139071345329285,
-1.406477451324463,
-0.0654517263174057,
-0.2707875370979309,
0.12593680620193481,
-0.13871261477470398,
-0.003949298057705164,
-0.07395144551992416,
0.15018285810947418,
-0.6738507747650146,
0.43464356660842896,
-0.11316227167844772,
0.48277127742767334,
-0.002117124618962407,
0.32988154888153076,
0.08024994283914566,
-0.2528012692928314,
0.2351684868335724,
-0.035526663064956665,
-0.09265337884426117,
-0.42579352855682373,
-0.4284406304359436,
-0.09073400497436523,
-0.41492486000061035,
0.32438382506370544,
-0.03117891028523445,
0.39195942878723145,
0.18728049099445343,
-0.16961409151554108,
-0.07251040637493134,
-0.24381546676158905,
-0.21713502705097198,
-0.5926107168197632,
0.17603403329849243,
-0.14602287113666534,
0.06516850739717484,
0.5735105276107788,
0.6354706287384033,
0.25112634897232056,
-0.5689021348953247,
-0.17387080192565918,
0.6525708436965942,
0.22662751376628876,
-0.8842484354972839,
0.5327299237251282,
0.14641284942626953,
0.16580119729042053,
-0.19204722344875336,
0.09442022442817688,
-0.029301751405000687,
0.5486181378364563,
0.0851522907614708,
0.3300926685333252,
0.8416210412979126,
-0.04686504602432251,
-0.24151135981082916,
-0.12774890661239624,
-0.37827637791633606,
0.8295173645019531,
0.22266511619091034,
-0.3130064606666565,
0.3818962872028351,
0.3812275230884552,
-0.3004833161830902,
-0.3302946388721466,
0.37556836009025574,
0.10654409974813461,
0.051057055592536926,
0.0027257981710135937,
0.3025793135166168,
0.8008483648300171,
0.6169241070747375,
-0.46601250767707825,
0.07611481100320816,
-0.17630331218242645,
0.13388624787330627,
0.44754377007484436,
-0.5117626786231995,
-0.3021810054779053,
-0.08838430047035217,
0.6328990459442139,
0.2511726915836334,
0.024838948622345924,
0.07050512731075287,
-0.39594924449920654,
0.39697033166885376,
0.39153018593788147,
0.5198937058448792,
-0.17494641244411469,
0.04809349402785301,
0.15967896580696106,
-0.12241058051586151,
-0.19011777639389038,
0.2108898162841797,
-0.1302071064710617,
0.11160977184772491,
0.21718312799930573,
-0.4302932620048523,
-0.5146250128746033,
0.13696672022342682,
-0.14342866837978363,
0.06019483879208565,
-0.18388408422470093,
-0.19296307861804962,
-0.31760382652282715,
-0.06719418615102768,
0.6974772214889526,
-0.0969814881682396,
0.019159819930791855,
-0.154888316988945,
-0.357272744178772,
0.7311224937438965,
-0.27830711007118225,
0.1913500279188156,
0.358855277299881,
-0.7229012846946716,
0.0798187255859375,
0.16206064820289612,
-0.11396967619657516,
0.054624754935503006,
0.020135918632149696,
-0.04942547529935837,
0.1632019281387329,
-0.41113361716270447,
-0.22804905474185944,
-0.10152135789394379,
-0.1320270448923111,
0.03393365815281868,
-0.09106221795082092,
-0.05531378462910652,
0.29377907514572144,
-0.46501871943473816,
0.23719041049480438,
0.05356456711888313,
0.030016954988241196,
-0.039815254509449005,
-0.21127797663211823,
0.9521538615226746,
0.32588469982147217,
0.25189408659935,
-0.08489292860031128,
0.011132219806313515,
0.07549676299095154,
0.39403754472732544,
-0.5871556401252747,
0.3477267324924469,
-0.31845003366470337,
-0.10955283045768738,
-0.6848186254501343,
0.13754618167877197,
0.37136611342430115,
-0.15873479843139648,
-0.2975863814353943,
0.028482863679528236,
0.07124915719032288,
0.6122897863388062,
0.24384231865406036,
-0.2120833545923233,
-0.23358109593391418,
-0.46899116039276123,
-0.3539833128452301,
-0.22118838131427765,
0.7134013175964355,
-0.34545138478279114,
0.3882104158401489,
-0.17061449587345123,
0.2739938497543335,
0.5992103219032288,
-0.14712035655975342,
0.673488438129425,
-0.6001735329627991,
0.04069396108388901,
-0.8075565099716187,
0.5688949823379517,
-0.36925190687179565,
0.17602737247943878,
0.22337500751018524,
0.2787229120731354,
0.3363189399242401,
-0.40370723605155945,
-0.1941826492547989,
-0.3196090757846832,
-0.11619582027196884,
0.5987292528152466,
-0.021174991503357887,
0.26061633229255676,
-0.060766641050577164,
-0.39388757944107056,
-0.8918687701225281,
0.4461266100406647,
0.08381106704473495,
-0.5620614290237427,
0.5469334721565247,
-0.129483163356781,
-0.3316679000854492,
0.2961282730102539,
-0.09610473364591599,
-0.49872466921806335,
-0.19692684710025787,
-0.04133443161845207
] |
Concerns have been raised regarding the availability of National Institute for Occupational Safety and Health (NIOSH)-certified N95 filtering facepiece respirators (FFRs) during an influenza pandemic. One possible strategy to mitigate a respirator shortage is to reuse FFRs following a biological decontamination process to render infectious material on the FFR inactive. However, little data exist on the effects of decontamination methods on respirator integrity and performance. This study evaluated five decontamination methods [ultraviolet germicidal irradiation (UVGI), ethylene oxide, vaporized hydrogen peroxide (VHP), microwave oven irradiation, and bleach] using nine models of NIOSH-certified respirators (three models each of N95 FFRs, surgical N95 respirators, and P100 FFRs) to determine which methods should be considered for future research studies. Following treatment by each decontamination method, the FFRs were evaluated for changes in physical appearance, odor, and laboratory performance (filter aerosol penetration and filter airflow resistance). Additional experiments (dry heat laboratory oven exposures, off-gassing, and FFR hydrophobicity) were subsequently conducted to better understand material properties and possible health risks to the respirator user following decontamination. However, this study did not assess the efficiency of the decontamination methods to inactivate viable microorganisms. Microwave oven irradiation melted samples from two FFR models. The remainder of the FFR samples that had been decontaminated had expected levels of filter aerosol penetration and filter airflow resistance. The scent of bleach remained noticeable following overnight drying and low levels of chlorine gas were found to off-gas from bleach-decontaminated FFRs when rehydrated with deionized water. UVGI, ethylene oxide (EtO), and VHP were found to be the most promising decontamination methods; however, concerns remain about the throughput capabilities for EtO and VHP. Further research is needed before any specific decontamination methods can be recommended. | [
0.0176490880548954,
0.018352147191762924,
-0.005718570202589035,
0.02243909239768982,
0.01556161418557167,
-0.02415974624454975,
0.011142462491989136,
0.026861870661377907,
-0.0149111682549119,
-0.021386127918958664,
-0.005030272528529167,
0.022349614650011063,
-0.03163060545921326,
0.0047842287458479404,
-0.019669940695166588,
-0.010517450049519539,
-0.004399175755679607,
0.042395710945129395,
0.01193115022033453,
0.00008452031761407852,
-0.00108057027682662,
0.009530812501907349,
0.011387648060917854,
0.012545705772936344,
-0.0020760262850672007,
-0.005790448747575283,
0.009876234456896782,
-0.016767878085374832,
-0.004768408834934235,
0.02984124794602394,
0.009201710112392902,
-0.0002474531065672636,
0.006999981589615345,
0.012113609351217747,
0.011818896979093552,
0.00369052030146122,
-0.010673977434635162,
0.02505580522119999,
0.03218058496713638,
-0.005477703642100096,
-0.009349612519145012,
-0.014973028562963009,
0.0007719816640019417,
-0.011387442238628864,
-0.005357920657843351,
0.013474244624376297,
-0.004497326910495758,
-0.00006203586235642433,
-0.001267730025574565,
0.003081848379224539,
-0.01073487475514412,
-0.03720137104392052,
0.0005661833565682173,
0.048112593591213226,
-0.007587877567857504,
-0.003615159075707197,
0.019436925649642944,
0.032038405537605286,
-0.06666965782642365,
0.006991066969931126,
0.004699391778558493,
-0.03010864555835724,
0.005685046780854464,
-0.026160577312111855,
0.012884842231869698,
-0.06599009037017822,
-0.004486186429858208,
0.025323297828435898,
0.02708304300904274,
-0.00633543636649847,
-0.005144556052982807,
0.012544052675366402,
-0.016794640570878983,
-0.008978893980383873,
0.018589161336421967,
0.014522711746394634,
0.0008885790593922138,
0.03293583169579506,
-0.025447668507695198,
-0.03943898528814316,
-0.004325671121478081,
-0.016696956008672714,
-0.01832086220383644,
0.01567242667078972,
0.005301058292388916,
0.01492799911648035,
-0.002667596796527505,
0.00939512625336647,
-0.0019712019711732864,
0.0457170307636261,
-0.0015069289365783334,
-0.036493659019470215,
-0.013741981238126755,
-0.012156855314970016,
-0.013822462409734726,
0.028136149048805237,
-0.01801018975675106,
0.0030273643787950277,
-0.001378529006615281,
0.012491647154092789,
-0.019547022879123688,
0.0204060859978199,
0.018090657889842987,
0.00909222662448883,
-0.030222756788134575,
0.013082451187074184,
0.0005307979881763458,
0.0005012893816456199,
0.013380402699112892,
0.007592774927616119,
0.024942396208643913,
0.04470285400748253,
-0.0008433111943304539,
0.031493429094552994,
-0.0042552584782242775,
0.025557730346918106,
0.007888169959187508,
0.030327627435326576,
0.013438692316412926,
-0.03333153575658798,
0.03649866580963135,
-0.007949750870466232,
0.01881139911711216,
-0.02156103402376175,
0.007131144404411316,
0.03690820187330246,
-0.04694350063800812,
-0.004564880393445492,
-0.017538411542773247,
0.0014141949359327555,
-0.015485787764191628,
-0.016898632049560547,
0.0007288511842489243,
-0.0014617335982620716,
0.04790545254945755,
0.007798412814736366,
0.0037580018397420645,
-0.03274783492088318,
0.006056745070964098,
-0.015302042476832867,
-0.0037633832544088364,
0.006270238664001226,
-0.0009421142749488354,
0.012424541637301445,
0.028351034969091415,
0.006959651596844196,
0.01792031154036522,
0.0006178137846291065,
0.04631919413805008,
0.0035883383825421333,
0.01440764032304287,
-0.022244557738304138,
-0.02258613519370556,
-0.012379420921206474,
0.02243819087743759,
-0.014536237344145775,
-0.007197904400527477,
-0.008571373298764229,
-0.006147283129394054,
0.022441042587161064,
0.01671387068927288,
-0.008848137222230434,
0.02172015979886055,
0.008835645392537117,
-0.0095956576988101,
-0.026326065883040428,
0.03273259103298187,
0.007849018089473248,
-0.00011117616668343544,
0.005091593600809574,
-0.008384011685848236,
0.01662716269493103,
-0.01287367194890976,
0.005061055533587933,
0.03876463696360588,
0.004227782133966684,
0.008326499722898006,
0.010064352303743362,
-0.010427047498524189,
0.06627769768238068,
-0.015900228172540665,
-0.00417460547760129,
0.014465219341218472,
0.02361583337187767,
-0.0043921759352087975,
-0.005951285362243652,
0.07123765349388123,
-0.013995833694934845,
0.013817796483635902,
0.021286457777023315,
0.013762181624770164,
-0.018042225390672684,
-0.008615948259830475,
-0.005636956542730331,
0.007710838690400124,
0.0026439237408339977,
-0.017418989911675453,
0.025035085156559944,
0.010816728696227074,
-0.028529051691293716,
0.0034679060336202383,
0.0022371243685483932,
0.03862966597080231,
0.013175761327147484,
-0.0313393771648407,
0.004579104017466307,
-0.007269931957125664,
-0.018172767013311386,
0.0028479702305048704,
-0.00878037977963686,
0.011172089725732803,
-0.020780295133590698,
0.013029795140028,
-0.012752901762723923,
0.02873387560248375,
-0.013558276928961277,
0.031073210760951042,
0.018034659326076508,
-0.016617635264992714,
-0.012506449595093727,
0.005034819710999727,
0.019499845802783966,
-0.010983463376760483,
-0.00694656278938055,
-0.021021604537963867,
0.006756661459803581,
-0.00495179696008563,
0.016897428780794144,
-0.003911355510354042,
0.020080747082829475,
0.004023859277367592,
-0.012250980362296104,
-0.015040943399071693,
0.02177128568291664,
0.023789022117853165,
0.006771765649318695,
0.01627817004919052,
-0.02275482937693596,
0.009005969390273094,
-0.018151817843317986,
-0.0010209176689386368,
0.011280735954642296,
0.025587595999240875,
0.007007031701505184,
-0.021962011232972145,
0.005264559295028448,
0.015039421617984772,
-0.007793622091412544,
0.005169152282178402,
0.0070334505289793015,
0.008640130050480366,
0.008096292614936829,
0.020953122526407242,
-0.011193467304110527,
0.051823291927576065,
-0.006671473383903503,
0.04838123172521591,
0.02275128662586212,
0.026227179914712906,
0.006670845672488213,
0.007631862070411444,
0.005371559876948595,
-0.050273045897483826,
-0.0070002516731619835,
0.0028690530452877283,
0.05253561586141586,
-0.01642308011651039,
-0.013980912044644356,
-0.0067830802872776985,
-0.0037170457653701305,
0.009274689480662346,
-0.010024722665548325,
-0.024473993107676506,
-0.08122896403074265,
-0.015454082749783993,
0.015850432217121124,
-0.019371628761291504,
0.008004887029528618,
0.018929965794086456,
-0.0020623761229217052,
0.02398037537932396,
-0.018117191269993782,
0.003107348456978798,
0.0018571135587990284,
0.018862679600715637,
-0.00029038568027317524,
0.029163654893636703,
-0.0074603441171348095,
-0.01427634060382843,
0.01114475168287754,
-0.0009138337336480618,
-0.03624115511775017,
-0.009086677804589272,
-0.003726003225892782,
0.004190234001725912,
0.03759457916021347,
-0.01214992068707943,
-0.016715943813323975,
0.009402113035321236,
0.001578297931700945,
-0.000599190010689199,
-0.004118267446756363,
0.007475210353732109,
0.010059097781777382,
-0.04246736690402031,
0.01678922027349472,
0.01435319148004055,
0.033187124878168106,
0.0012833045329898596,
0.003564707934856415,
-0.010614903643727303,
-0.006688709836453199,
-0.0017866517882794142,
-0.00020335917361080647,
0.011252024210989475,
0.003965971525758505,
-0.003305630525574088,
-0.009997205808758736,
0.018192056566476822,
-0.002235804218798876,
-0.010229735635221004,
0.02091001346707344,
-0.011371255852282047,
-0.007194889709353447,
-0.012485602870583534,
0.024280836805701256,
0.016223803162574768,
-0.021746482700109482,
-0.004924279637634754,
-0.0029995599761605263,
0.026139196008443832,
-0.012537522241473198,
-0.02395191416144371,
0.004074199125170708,
0.018410418182611465,
-0.0148898521438241,
0.01653849147260189,
0.0006740838289260864,
0.0029938959050923586,
0.02613886259496212,
0.001002296805381775,
-0.021872123703360558,
0.028702815994620323,
0.023825155571103096,
0.0037380876019597054,
-0.009380887262523174,
0.0022816448472440243,
-0.0022582951933145523,
-0.016520744189620018,
-0.01493249274790287,
-0.0015759787056595087,
0.0012550028041005135,
0.003275472903624177,
-0.02338486537337303,
0.003811424132436514,
-0.021692903712391853,
0.0006875719409435987,
-0.029116567224264145,
-0.012413794174790382,
0.012476261705160141,
-0.019269082695245743,
0.00986486952751875,
-0.01843458041548729,
0.00007419241592288017,
-0.005824222695082426,
-0.029916640371084213,
0.005618968978524208,
-0.016312213614583015,
-0.005486960522830486,
-0.01399681344628334,
-0.02720463275909424,
0.010932832956314087,
0.011995566077530384,
-0.034906916320323944,
-0.008199375122785568,
-0.005941594950854778,
-0.011096742004156113,
-0.0014517223462462425,
0.009596472606062889,
0.011194193735718727,
-0.027826599776744843,
0.0004479745402932167,
-0.011368021368980408,
-0.0017197858542203903,
0.0169837586581707,
-0.009010372683405876,
-0.019511578604578972,
0.021943625062704086,
0.02557021751999855,
0.016517704352736473,
-0.011450279504060745,
0.07181552052497864,
-0.012182973325252533,
0.01606602594256401,
-0.01614553853869438,
-0.0004811091348528862,
-0.009437846019864082,
0.0035276664420962334,
-0.005676292814314365,
0.03452490270137787,
-0.01369040459394455,
0.014187403954565525,
-0.028659621253609657,
-0.007464634254574776,
-0.008634606376290321,
-0.00007182883564382792,
-0.00695223081856966,
0.012020528316497803,
-0.0419672355055809,
0.035997845232486725,
0.03373179957270622,
0.00899711437523365,
-0.030727282166481018,
0.009838340803980827,
-0.0057446714490652084,
0.0033020307309925556,
0.026731228455901146,
0.002798194531351328,
-0.012779942713677883,
-0.006398139521479607,
0.009631464257836342,
0.00039494968950748444,
-0.018486719578504562,
-0.004951075185090303,
-0.0017404938116669655,
0.03461042419075966,
0.010468972846865654,
0.008073972538113594,
-0.010705294087529182,
0.013936148025095463,
0.014944310300052166,
0.013768426142632961,
-0.01918061077594757,
-0.011746566742658615,
0.004361795261502266,
-0.01176665723323822,
0.005109889432787895,
0.013694862835109234,
-0.011986063793301582,
0.00010339310392737389,
0.02028394490480423,
-0.007869119755923748,
0.00004724669270217419,
0.00902494229376316,
-0.02424785867333412,
-0.0031496507581323385,
-0.005889276973903179,
0.023801155388355255,
0.006920196115970612,
0.019243411719799042,
-0.0048704748041927814,
-0.0014971992932260036,
-0.011303095147013664,
-0.012212758883833885,
-0.008802907541394234,
0.028948180377483368,
-0.021605364978313446,
-0.00011373532470315695,
-0.00298300851136446,
-0.0181876290589571,
0.01235228218138218,
0.007383011281490326,
-0.007158301770687103,
-0.02756492793560028,
-0.014515120536088943,
-0.006699640303850174,
-0.008502914570271969,
0.00918556284159422,
0.025847844779491425,
0.019329851493239403,
-0.036089904606342316,
-0.0364769883453846,
0.03138155862689018,
0.024176113307476044,
-0.013303546234965324,
-0.001985557610169053,
-0.014606920070946217,
0.01794932596385479,
-0.07403933256864548,
-0.0057001300156116486,
-0.003135454608127475,
-0.010739335790276527,
0.005919579416513443,
0.048966746777296066,
-0.02147597260773182,
-0.0022501612547785044,
-0.026055604219436646,
-0.0073327673599123955,
-0.011919881217181683,
0.023969687521457672,
0.0492158904671669,
-0.018853865563869476,
0.012328602373600006,
0.012550055980682373,
-0.00737363938242197,
0.008945925161242485,
-0.04166025295853615,
0.007816502824425697,
0.021573929116129875,
0.0014884751290082932,
-0.04570048302412033,
-0.01414855383336544,
0.007013814989477396,
-0.08060704171657562,
-0.022472459822893143,
0.022862248122692108,
-0.035176172852516174,
-0.007522347383201122,
-0.015390310436487198,
0.02254355512559414,
-0.01861749216914177,
0.008842086419463158,
-0.017207082360982895,
-0.006221777759492397,
0.011999622918665409,
0.004247468896210194,
0.010694395750761032,
-0.012737303040921688,
-0.01275467500090599,
-0.000848867348395288,
0.020577453076839447,
-0.023870812729001045,
-0.023810507729649544,
0.007065968122333288,
0.028196990489959717,
-0.010189910419285297,
-0.010532675310969353,
-0.01083175465464592,
0.030748926103115082,
-0.01942642778158188,
0.010889898985624313,
0.023755216971039772,
-0.021291714161634445,
-0.0038258603308349848,
0.008709335699677467,
0.012374905869364738,
-0.02765767276287079,
0.021440107375383377,
-0.022430073469877243,
0.002114980947226286,
0.011436805129051208,
-0.03693879023194313,
0.020715788006782532,
-0.0031541716307401657,
0.021474076434969902,
-0.015187582932412624,
0.006474666763097048,
0.0008882172405719757,
-0.009099569171667099,
0.006056786980479956,
-0.014625664800405502,
0.030096130445599556,
0.0033082137815654278,
0.0044953166507184505,
-0.021052183583378792,
-0.0036654456052929163,
0.008789073675870895,
-0.004143917933106422,
0.002111278008669615,
-0.011564345099031925,
0.0224558487534523,
0.01179767306894064,
0.01127755455672741,
-0.0039629507809877396,
0.024709338322281837,
0.0005859003867954016,
0.07122468203306198,
0.014467334374785423,
0.005328203551471233,
-0.0034594854805618525,
-0.012097455561161041,
0.00946551188826561,
0.00955820083618164,
-0.010253172367811203,
0.012798001989722252,
-0.0036768256686627865,
0.0031546081881970167,
-0.021784763783216476,
0.02302209846675396,
0.0123785100877285,
0.008279490284621716,
-0.0023075570352375507,
-0.022395197302103043,
-0.003756491933017969,
-0.04121623933315277,
0.023481514304876328,
-0.004689573310315609,
0.010083412751555443,
-0.026391327381134033,
-0.015900228172540665,
0.023068757727742195,
-0.0051497360691428185,
-0.028701746836304665,
-0.00205437489785254,
0.01719038560986519,
0.020343102514743805,
0.004614484030753374,
-0.03414316475391388,
0.009323361329734325,
-0.011529822833836079,
0.014937740750610828,
-0.04840993881225586,
0.017992625012993813,
0.011201908811926842,
-0.015626223757863045,
0.011971622705459595,
-0.004280836321413517,
0.02454189769923687,
-0.00410087127238512,
-0.012017698958516121,
0.02282894402742386,
-0.019859815016388893,
-0.01715613529086113,
0.01657344028353691,
0.007949509657919407,
0.012638981454074383,
-0.004650300834327936,
0.001757908146828413,
0.015422787517309189,
-0.031200099736452103,
-0.025909461081027985,
0.010008320212364197,
-0.0425729937851429,
0.01968412846326828,
-0.008634775876998901,
0.0019881385378539562,
-0.010659885592758656,
-0.007185766473412514,
0.006300043314695358,
-0.027514740824699402,
0.01727042719721794,
-0.034573305398225784,
-0.006784219294786453,
-0.01768789440393448,
-0.013436159119009972,
0.01876112073659897,
-0.014216743409633636,
0.00868053175508976,
0.009372781962156296,
0.00016626063734292984,
0.010704286396503448,
0.00430887658149004,
0.008896468207240105,
0.00035150395706295967,
0.018939457833766937,
0.02189801260828972,
-0.020728658884763718,
-0.015337970107793808,
0.010931864380836487,
0.027910832315683365,
-0.005674624815583229,
-0.012015565298497677,
0.013598781079053879,
-0.010819750837981701,
-0.008355539292097092,
0.015636015683412552,
-0.005384506192058325,
0.011703782714903355,
0.005607382394373417,
0.011401727795600891,
0.004771465435624123,
0.03514309972524643,
0.011172527447342873,
0.007827186025679111,
0.0013875400181859732,
0.020605186000466347,
0.027146754786372185,
0.013853284530341625,
-0.003246000502258539,
0.02784956619143486,
-0.0007747747004032135,
-0.007015742361545563,
0.0011536171659827232,
0.025574497878551483,
-0.021925369277596474,
-0.028748463839292526,
-0.0039820484817028046,
0.031226083636283875,
0.023068968206644058,
-0.012331647798418999,
0.002163938246667385,
-0.01845289207994938,
-0.00855410285294056,
-0.01547564473003149,
-0.006936270743608475,
-0.004655449651181698,
-0.024655450135469437,
-0.00559934601187706,
0.008732831105589867,
0.036872562021017075,
-0.014434408396482468,
0.008716236799955368,
-0.0034899108577519655,
0.018031848594546318,
0.008672695606946945,
0.0187353678047657,
0.025133848190307617,
-0.012839233502745628,
-0.010344446636736393,
0.00568752083927393,
-0.000027224887162446976,
-0.016424527391791344,
-0.0077500478364527225,
0.02501126378774643,
-0.0020494824275374413,
-0.008891245350241661,
-0.009636107832193375,
0.0020250813104212284,
0.00656532496213913,
-0.01173109095543623,
0.00890151597559452,
-0.021716918796300888,
0.00286876130849123,
0.01234455592930317,
0.012998592108488083,
-0.0038191257044672966,
-0.008920330554246902,
0.009683338925242424,
0.012177341617643833,
-0.0038882442750036716,
0.020284896716475487,
0.0050543565303087234,
0.005260078702121973,
0.0016218845266848803,
-0.015803564339876175,
0.00759850675240159,
-0.005666804034262896,
0.03234448283910751,
0.04620237648487091,
0.0070620086044073105,
-0.014663998037576675,
0.0006696917116641998,
-0.007090700324624777,
0.03515595197677612,
-0.03725002706050873,
0.00770185049623251,
0.011163630522787571,
-0.01739039644598961,
0.03196936845779419,
-0.018602484837174416,
-0.005561466328799725,
-0.004575349390506744,
-0.01108994334936142,
-0.011296824552118778,
-0.039722319692373276,
0.01953236013650894,
0.007196596823632717,
-0.00883769616484642,
0.006720388773828745,
-0.012592028826475143,
0.0049418238922953606,
-0.0017552635399624705,
-0.013125237077474594,
0.017595937475562096,
0.001139459665864706,
-0.0006789099425077438,
-0.0156966894865036,
0.01527523435652256,
-0.011146556586027145,
0.0389019250869751,
0.006078984588384628,
-0.017513558268547058,
0.01707688719034195,
-0.03699791803956032,
-0.001719246618449688,
0.024982979521155357,
-0.005653701722621918,
-0.01643696427345276
] | [
0.3527359664440155,
-0.0432073138654232,
0.044123463332653046,
0.06557188928127289,
-0.09674631804227829,
-0.084784135222435,
0.23216165602207184,
-0.2918136715888977,
-0.3334176540374756,
-0.6665475964546204,
-0.09724109619855881,
0.2656922936439514,
-0.29781949520111084,
0.22281122207641602,
0.047300681471824646,
0.6887809038162231,
0.6449442505836487,
0.43465614318847656,
-0.3563440144062042,
-0.3895805776119232,
-0.07729214429855347,
-0.47425609827041626,
0.27587443590164185,
-0.29283493757247925,
0.07735684514045715,
-0.17235423624515533,
0.28570905327796936,
-0.037917401641607285,
0.00888020172715187,
0.28038695454597473,
0.3250703811645508,
0.7013536691665649,
-0.07181727141141891,
-0.5237078070640564,
0.2919515371322632,
0.4537888169288635,
-0.49678462743759155,
-0.046824220567941666,
-0.13464847207069397,
-0.06854210048913956,
-0.28760480880737305,
-0.3704241216182709,
-0.19459369778633118,
0.09587018936872482,
-0.27258214354515076,
-0.28277572989463806,
-1.31012761592865,
0.47387656569480896,
0.32257920503616333,
0.19191764295101166,
0.23206575214862823,
0.1889064908027649,
-0.045022182166576385,
0.17896926403045654,
0.4437493085861206,
0.13859163224697113,
-0.25247716903686523,
-0.3712221384048462,
0.2295951396226883,
-0.3703083395957947,
0.10551244020462036,
-0.20484024286270142,
-0.36007753014564514,
0.0658276379108429,
-0.30887341499328613,
0.6518044471740723,
0.026392068713903427,
0.14259126782417297,
-0.6966010928153992,
-0.29793933033943176,
0.2800700068473816,
-0.371287077665329,
-0.07881145179271698,
-0.09659156948328018,
-0.08547224849462509,
0.05931878089904785,
0.026967892423272133,
-0.5275591015815735,
-0.06954991817474365,
0.4847242832183838,
0.06864460557699203,
0.4041423797607422,
0.5294637084007263,
-0.14515523612499237,
0.4781927168369293,
0.2333824783563614,
-0.15469956398010254,
0.6697157025337219,
-0.17728443443775177,
-0.18060564994812012,
0.27163851261138916,
-0.2060210108757019,
0.9141145944595337,
0.4072437584400177,
0.05228468403220177,
0.09234891086816788,
0.011860801838338375,
0.11705988645553589,
0.13493160903453827,
0.2618951201438904,
-0.16255426406860352,
-0.28770485520362854,
-0.0699155181646347,
0.04419560730457306,
-0.08621995151042938,
-0.47483670711517334,
-0.37517932057380676,
-0.5617377758026123,
-0.1461644023656845,
0.09022732079029083,
-0.2575984597206116,
0.43374398350715637,
-0.04694827273488045,
-0.47231754660606384,
-0.5436890721321106,
-0.04074082151055336,
0.2974219024181366,
-0.002180110663175583,
0.49684327840805054,
0.38397839665412903,
0.6863870620727539,
0.9934967160224915,
-0.11048544198274612,
0.29085004329681396,
-0.09692838788032532,
-0.24990132451057434,
0.744079053401947,
0.39762794971466064,
-0.6386475563049316,
0.0592624768614769,
0.10834041237831116,
0.8252150416374207,
-0.35275065898895264,
0.04893901199102402,
-0.06013473495841026,
-0.18254722654819489,
-0.17361411452293396,
0.08430035412311554,
0.4127168655395508,
-0.058169860392808914,
-0.30714181065559387,
-0.7554566264152527,
-0.4993092715740204,
-0.4654301702976227,
-0.23188625276088715,
-0.29817643761634827,
-0.177277609705925,
0.5621550679206848,
-0.4098673164844513,
-0.2928546369075775,
0.043734122067689896,
-0.2617631256580353,
-0.3139115571975708,
0.07422865182161331,
-0.20206977427005768,
-0.050174325704574585,
-0.29476815462112427,
-0.23563094437122345,
-0.021529924124479294,
-0.2023061364889145,
0.10550753772258759,
0.09895864129066467,
-0.7252435088157654,
0.07829610258340836,
0.3772469162940979,
0.27818235754966736,
-0.0900818333029747,
0.4645642340183258,
-0.018077818676829338,
-0.26588019728660583,
0.03297910466790199,
0.20812886953353882,
0.3076710104942322,
-0.8186376690864563,
0.5240142941474915,
0.36609259247779846,
0.6618347764015198,
0.2689739763736725,
0.4812302887439728,
0.5379244685173035,
-0.6522716283798218,
-0.5195675492286682,
0.07734046876430511,
-0.2690129578113556,
-0.06343456357717514,
0.3268405497074127,
0.3802657127380371,
-0.037182312458753586,
0.04313497990369797,
0.23176908493041992,
-0.4993487000465393,
-0.11643342673778534,
0.4198903739452362,
-0.4417383074760437,
0.8222496509552002,
-0.24846437573432922,
-0.16919708251953125,
1.208733081817627,
0.0895967036485672,
0.15354685485363007,
0.03735540434718132,
0.23531438410282135,
0.304400771856308,
-0.35967817902565,
-1.1836059093475342,
0.11254391074180603,
0.20914645493030548,
0.0913994237780571,
-0.5709438323974609,
0.12148448824882507,
0.9941519498825073,
-0.6213651895523071,
-0.3789420425891876,
-0.18305447697639465,
0.1335376650094986,
0.21574333310127258,
-0.4686187207698822,
0.1823493391275406,
0.01094822771847248,
-0.28214550018310547,
0.1468360275030136,
-0.3235799968242645,
0.07982966303825378,
0.40371888875961304,
-0.35681721568107605,
0.3300459682941437,
0.27737733721733093,
-0.10941296815872192,
0.7214964628219604,
-1.0291842222213745,
0.5206774473190308,
-0.5058319568634033,
-0.03249649703502655,
-0.7691848874092102,
-0.5194777846336365,
0.1932166963815689,
-0.1360802799463272,
-0.3270748257637024,
0.5193367004394531,
-0.15967531502246857,
0.055166732519865036,
0.059740398079156876,
-0.1034899652004242,
0.30010926723480225,
0.23046404123306274,
-0.12169324606657028,
0.29491227865219116,
0.5353763699531555,
-0.2324484884738922,
0.19678156077861786,
0.3775478005409241,
0.6121724843978882,
0.04215440899133682,
-0.664120078086853,
0.10924936830997467,
0.4368536174297333,
0.008020310662686825,
-0.052761465311050415,
0.08819405734539032,
-0.4676080644130707,
0.04367097094655037,
0.4085373282432556,
0.012778089381754398,
-0.08108241111040115,
-0.23727798461914062,
-0.6570071578025818,
-0.7546700239181519,
0.09497757256031036,
0.36684590578079224,
0.7215789556503296,
0.20706112682819366,
0.028976857662200928,
-0.4716815948486328,
0.25313228368759155,
-0.010644389316439629,
-0.15327109396457672,
0.5312851667404175,
0.822163462638855,
-0.6200588345527649,
-0.1739112138748169,
0.11828998476266861,
0.20495069026947021,
0.9595097899436951,
-0.2817455232143402,
-0.5242416858673096,
-0.3987485468387604,
0.27419501543045044,
-0.2644166946411133,
-0.6726255416870117,
-0.3012170195579529,
-0.5012966990470886,
0.46309927105903625,
0.029223835095763206,
0.2761654555797577,
0.11983419209718704,
-0.07634726911783218,
-0.3892301023006439,
0.3133101165294647,
0.7421500086784363,
-0.06852827966213226,
-0.32650065422058105,
0.018220825120806694,
-0.028175516054034233,
-0.11630430072546005,
-0.3183474838733673,
0.018343769013881683,
-0.36376699805259705,
0.08445817977190018,
-5.957114219665527,
0.056539956480264664,
-0.30567026138305664,
0.405687153339386,
-0.43155965209007263,
0.43027570843696594,
0.9061240553855896,
-0.20732447504997253,
0.20963023602962494,
0.3504631817340851,
0.6507421731948853,
0.7751746773719788,
0.5825871825218201,
0.022299787029623985,
-0.337978720664978,
0.4646519422531128,
0.33830526471138,
-0.35982078313827515,
0.06549881398677826,
-0.19236545264720917,
0.2948487401008606,
0.03257285803556442,
-0.08365783095359802,
0.21133002638816833,
0.1811395287513733,
-0.3880329728126526,
-0.7856298685073853,
0.39339888095855713,
-0.15731871128082275,
-0.2609008550643921,
0.42298424243927,
-0.01271173544228077,
-0.1419438123703003,
0.07807134836912155,
0.12169810384511948,
-0.010900812223553658,
0.43643927574157715,
-0.19894684851169586,
-0.5084099173545837,
-0.021847300231456757,
0.35400858521461487,
0.23519116640090942,
-0.13879252970218658,
-0.00604398176074028,
0.37306347489356995,
0.13059376180171967,
0.10252410173416138,
-0.1605793684720993,
0.04606618359684944,
0.5212460160255432,
0.363723486661911,
-0.3967253267765045,
0.23440246284008026,
0.7951631546020508,
0.32050931453704834,
0.16970211267471313,
-0.03822185471653938,
0.42196667194366455,
-0.22995886206626892,
0.028538431972265244,
-0.08555979281663895,
0.06724175065755844,
-0.30005937814712524,
-0.18695084750652313,
-0.047889988869428635,
-0.25068366527557373,
-0.6324759125709534,
-0.7568933963775635,
0.4424346685409546,
-0.05958356335759163,
-0.3201172947883606,
0.2789977490901947,
0.2157095968723297,
-0.7715221047401428,
0.33217042684555054,
-0.23864483833312988,
0.6617594957351685,
-0.31432461738586426,
-0.6275686025619507,
0.24356168508529663,
-0.43446609377861023,
-0.5290731191635132,
0.24882127344608307,
-0.31983375549316406,
-0.016034875065088272,
-0.10470553487539291,
0.2960360646247864,
0.15323813259601593,
0.17570240795612335,
0.15538322925567627,
0.6131435632705688,
-0.09838163107633591,
0.0314427986741066,
-0.14791780710220337,
0.08071079850196838,
0.5409391522407532,
0.4975978136062622,
0.3955410420894623,
0.37198108434677124,
0.19078168272972107,
0.4167817533016205,
-0.048482947051525116,
-0.01703784428536892,
-1.1448007822036743,
-0.33692115545272827,
0.3316369652748108,
-0.15571966767311096,
-0.06671041995286942,
0.9817400574684143,
-0.7198646068572998,
0.2395162284374237,
-0.10328406095504761,
0.1740589439868927,
0.2803882956504822,
0.545680820941925,
-0.4474327266216278,
-0.03813394904136658,
0.4505261778831482,
0.11070381104946136,
-0.3565702736377716,
0.2834225296974182,
0.6583486199378967,
-0.8139128088951111,
0.39192327857017517,
-0.20087553560733795,
-0.4416794180870056,
-0.0350799597799778,
0.35824501514434814,
-0.5072917342185974,
0.004864164628088474,
0.21337229013442993,
0.7433010935783386,
-0.7546764016151428,
0.23286929726600647,
0.3119337260723114,
-0.444757342338562,
-0.6386994123458862,
0.16034841537475586,
0.39029255509376526,
-0.1301300972700119,
0.09060528129339218,
-0.3304946720600128,
0.04654302820563316,
-0.15391714870929718,
0.38543304800987244,
0.5168489813804626,
0.16395585238933563,
-0.2766226530075073,
-0.3360038697719574,
0.0766470730304718,
0.16546571254730225,
0.04497958719730377,
-0.18361923098564148,
-0.23418036103248596,
-0.2716630697250366,
0.3179680109024048,
0.5739476084709167,
0.15376268327236176,
0.4325180947780609,
-0.5343064069747925,
0.5585625171661377,
0.3928038477897644,
-1.0834606885910034,
-0.49160102009773254,
0.14651520550251007,
-0.05827751383185387,
-0.13755379617214203,
-0.15266790986061096,
-0.2601694166660309,
0.3263877332210541,
-0.31526419520378113,
-0.25420892238616943,
-0.7163203358650208,
0.07716111838817596,
0.3284498155117035,
0.10906992107629776,
-0.18573176860809326,
-0.3742406964302063,
-0.2055608481168747,
0.013437648303806782,
-0.005911366082727909,
-0.2567289471626282,
-0.31304508447647095,
0.18812847137451172,
-0.13743196427822113,
-0.11765077710151672,
-0.20514854788780212,
-0.15979261696338654,
-0.5891861319541931,
-0.4008161425590515,
0.32735612988471985,
-0.11112011224031448,
0.2536960244178772,
-0.10196035355329514,
-0.2527327835559845,
-0.3379182517528534,
-0.22714781761169434,
0.8471996188163757,
-0.38021206855773926,
-0.32586297392845154,
0.03948770463466644,
0.34927812218666077,
-0.7460083961486816,
0.18663111329078674,
-0.12328890711069107,
-0.36918941140174866,
-0.47369077801704407,
0.06644356995820999,
-0.08488389849662781,
-0.3601161241531372,
-0.24617226421833038,
-0.7029277086257935,
-0.25651904940605164,
0.4800412058830261,
0.018264081329107285,
0.040279556065797806,
0.05666237324476242,
-0.19657115638256073,
-0.11544174700975418,
-0.01276421919465065,
-0.03694631904363632,
-0.02338232658803463,
0.3744668662548065,
0.28560885787010193,
-0.5393729209899902,
0.6364609003067017,
0.24255986511707306,
-0.9540411829948425,
0.12641362845897675,
0.42431187629699707,
-0.31199735403060913,
0.09669776260852814,
0.05441684648394585,
0.35378849506378174,
-0.4330269396305084,
-0.20106324553489685,
-0.517723023891449,
-0.07542887330055237,
-0.0821746438741684,
0.5381925106048584,
0.01867584139108658,
0.04036059230566025,
-0.44137969613075256,
-0.43015334010124207,
-0.6077723503112793,
-0.3547022342681885,
0.4241521954536438,
-0.370725154876709,
-0.7599809765815735,
0.3773896396160126,
0.003909044433385134,
0.012389909476041794,
0.2100316882133484,
-0.11641233414411545,
0.8211531043052673,
-0.1972438246011734,
0.2884192168712616,
-0.23886379599571228,
-0.17119796574115753,
0.5286524295806885,
-0.5750037431716919,
0.12118875980377197,
-0.4636548161506653,
-0.01272945012897253,
0.09928609430789948,
-0.07543760538101196,
-0.035608548671007156,
-0.986644983291626,
0.13253328204154968,
-0.6461461782455444,
0.2537727653980255,
0.33438536524772644,
0.7603210806846619,
0.9050984978675842,
0.3743095099925995,
0.06369577348232269,
-0.3839176297187805,
0.30636730790138245,
0.05458065867424011,
0.07137198001146317,
-0.3053782284259796,
-0.4121948480606079,
-0.4152173697948456,
-0.470265656709671,
0.16605974733829498,
-0.46650752425193787,
0.4280216097831726,
-0.10773579776287079,
-0.5796476602554321,
-0.7394160628318787,
-0.19093729555606842,
0.301823228597641,
-0.643109917640686,
-0.05197037756443024,
-0.12951630353927612,
0.042959585785865784,
-0.07798861712217331,
-0.052164122462272644,
-0.4862690567970276,
-0.20567744970321655,
-0.34309276938438416,
0.21145600080490112,
0.25784456729888916,
-0.23854604363441467,
0.060063961893320084,
-0.059427179396152496,
0.3653812110424042,
0.14393968880176544,
0.09228897839784622,
-0.01295646745711565,
0.12034280598163605,
-0.18159516155719757,
0.5699527859687805,
0.5803976058959961,
-0.40148332715034485,
0.3509176969528198,
0.16651274263858795,
0.13329820334911346,
0.36632806062698364,
0.061810512095689774,
0.3279154300689697,
0.5182176828384399,
0.358692467212677,
0.11640037596225739,
-0.7456438541412354,
0.5492769479751587,
-0.04648745432496071,
0.42281535267829895,
0.4019611179828644,
0.4269586205482483,
0.24709710478782654,
0.13826271891593933,
-0.2950907349586487,
0.386868417263031,
0.16240456700325012,
0.17047210037708282,
-0.1347467303276062,
-0.4769492447376251,
-0.571979820728302,
0.10389277338981628,
0.8493614196777344,
0.6854336857795715,
0.13018502295017242,
0.04583832249045372,
0.2109726220369339,
0.6530096530914307,
0.05310970917344093,
0.04188818484544754,
0.037832655012607574,
0.16509315371513367,
-0.1647043079137802,
-0.08045323938131332,
-0.09686515480279922,
0.3260275423526764,
-0.10001525282859802,
0.19429777562618256,
0.2543950080871582,
-0.47618889808654785,
-0.3447214961051941,
0.1796548217535019,
-0.10838770866394043,
0.01962137036025524,
-0.009991300292313099,
-0.06832129508256912,
-0.6078425645828247,
-0.3673412799835205,
-0.29382210969924927,
0.3738654851913452,
-0.3773197531700134,
-0.17359782755374908,
0.30003583431243896,
0.0784941166639328,
-0.07148946821689606,
0.4982854425907135,
0.3863266706466675,
-0.5527058839797974,
0.4129739999771118,
-0.051409270614385605,
0.14402760565280914,
0.35694509744644165,
-0.01948593556880951,
0.3144817650318146,
-0.10286624729633331,
-0.5385474562644958,
-0.09607408195734024,
0.12500303983688354,
-0.4417366683483124,
0.014998608268797398,
0.4636289179325104,
-0.4927275478839874,
-0.334173321723938,
-0.21094226837158203,
-0.9277148246765137,
0.16667939722537994,
-0.0031342923175543547,
-0.5402542352676392,
0.5526567697525024,
0.5207002758979797,
-0.06320670992136002,
0.5314522385597229,
0.33785325288772583,
0.10714243352413177,
-0.2594524025917053,
0.2625826597213745,
-0.7109553217887878,
0.4216274619102478,
-0.42498570680618286,
0.4153725504875183,
-0.3675229549407959,
0.23494651913642883,
0.6645404100418091,
0.26212313771247864,
-0.21666297316551208,
0.10484356433153152,
-0.4130101799964905,
-0.15535855293273926,
0.5071272850036621,
-0.663138747215271,
0.08498416841030121,
-0.7652764916419983,
0.04597220569849014,
-0.6194000244140625,
0.3963906168937683,
-0.276084840297699,
-0.18177151679992676,
-0.1856423318386078,
0.5477187633514404,
0.2815174460411072,
0.41512784361839294,
0.6526159048080444,
-0.6707485318183899,
-0.19693230092525482,
-0.5903744101524353,
0.6007729172706604,
-0.7973886728286743,
0.0448782779276371,
-0.22606660425662994,
0.24242669343948364,
0.29529133439064026,
-0.11059721559286118,
0.34520113468170166,
-0.270637571811676,
0.32710570096969604,
-0.09883181750774384,
0.16017000377178192,
0.4577751159667969,
-0.32882311940193176,
-0.1770196557044983,
0.04756932333111763,
0.6270716190338135,
-0.31567198038101196,
-0.5105170011520386,
-0.14026835560798645,
0.10702165216207504,
0.22831708192825317,
-0.18140198290348053,
-0.20724567770957947,
0.17456263303756714,
-0.24803707003593445,
-0.37622368335723877
] |
Methanolic extracts of 41 plant species belonging to 27 families used in the traditional medicine in Nepal have been investigated for in vitro antiviral activity against Herpes simplex virus type 1 (HSV-1) and influenza virus A by dye uptake assay in the systems HSV-1/Vero cells and influenza virus A/MDCK cells. The extracts of Astilbe rivularis, Bergenia ciliata, Cassiope fastigiata and Thymus linearis showed potent anti-herpes viral activity. The extracts of Allium oreoprasum, Androsace strigilosa, Asparagus filicinus, Astilbe rivularis, Bergenia ciliata and Verbascum thapsus exhibited strong anti-influenza viral activity. Only the extracts of A. rivularis and B. ciliata demonstrated remarkable activity against both viruses. | [
0.013846566900610924,
0.011979981325566769,
-0.0009224832756444812,
0.024631787091493607,
-0.023732846602797508,
0.016797084361314774,
0.010172056034207344,
-0.00921123381704092,
-0.017433064058423042,
-0.028937704861164093,
-0.0005753404693678021,
0.010056952014565468,
-0.007908724248409271,
0.005612608045339584,
0.005577718839049339,
-0.0035173448268324137,
-0.019126495346426964,
0.014166459441184998,
0.01843304932117462,
-0.00612210389226675,
0.02016427181661129,
-0.007152216974645853,
0.009699909016489983,
-0.00025602756068110466,
-0.006812920793890953,
0.022389959543943405,
0.015827104449272156,
-0.015519031323492527,
-0.005879053380340338,
0.006035910453647375,
0.023064425215125084,
-0.009921255521476269,
0.005495766177773476,
-0.007024784572422504,
0.003207193687558174,
-0.0010890376288443804,
-0.002175586763769388,
0.02033020183444023,
0.019825845956802368,
-0.0032224808819592,
0.009056312963366508,
-0.010631397366523743,
0.002326984889805317,
-0.027696702629327774,
-0.00730265025049448,
-0.019193029031157494,
-0.006930663716048002,
0.0033455730881541967,
0.00412764772772789,
0.007248839363455772,
-0.013368900865316391,
-0.02731115184724331,
-0.010561497882008553,
0.008051536977291107,
-0.0071588666178286076,
-0.017277749255299568,
0.0176021009683609,
0.018397454172372818,
0.0255325585603714,
0.012851179577410221,
-0.009898658841848373,
-0.017928864806890488,
0.00020581111311912537,
0.016667461022734642,
-0.021168190985918045,
-0.06616684794425964,
0.002306664362549782,
0.010412391275167465,
0.013713235035538673,
0.007228678558021784,
-0.013167900033295155,
0.015145674347877502,
0.005977879278361797,
-0.023678384721279144,
-0.014448098838329315,
0.01146840862929821,
-0.0037330887280404568,
0.029243232682347298,
-0.0025607405696064234,
-0.006831254810094833,
0.03804218769073486,
0.007710481993854046,
0.00959012471139431,
0.009918583557009697,
-0.007154728285968304,
-0.003957077860832214,
-0.02530449442565441,
0.0010831960244104266,
0.020493585616350174,
-0.021068161353468895,
-0.015712911263108253,
-0.011821568012237549,
-0.0006871544755995274,
-0.004044916480779648,
0.027384314686059952,
-0.030677085742354393,
0.00018751341849565506,
-0.004059592727571726,
-0.010329687967896461,
-0.015404976904392242,
-0.0037549252156168222,
0.02333707921206951,
0.012561773881316185,
0.023972995579242706,
-0.0034443973563611507,
0.006315772421658039,
-0.020342756062746048,
-0.012031377293169498,
0.03150324523448944,
0.004919528029859066,
-0.01223647128790617,
-0.013066612184047699,
0.012148525565862656,
0.029899708926677704,
-0.0008475454524159431,
0.0027408860623836517,
-0.010859205387532711,
0.009497744962573051,
0.002492528175935149,
-0.02754363790154457,
0.0014210408553481102,
-0.03067365661263466,
-0.005185270681977272,
-0.009733401238918304,
0.006620155181735754,
-0.0011721998453140259,
-0.027060972526669502,
-0.015065876767039299,
0.03943602740764618,
-0.018402935937047005,
-0.0072352830320596695,
0.0006010180804878473,
0.003161044791340828,
-0.016529502347111702,
-0.010919781401753426,
0.0038931691087782383,
0.004074394702911377,
-0.021902579814195633,
-0.014708616770803928,
-0.002473491244018078,
-0.01732812076807022,
0.007359045557677746,
0.002544144168496132,
0.01565653644502163,
-0.004309667274355888,
0.006860106252133846,
0.003166147507727146,
-0.006282594054937363,
0.01851877197623253,
0.0068084727972745895,
-0.0189201720058918,
-0.022344667464494705,
0.0013468842953443527,
-0.004521212540566921,
0.01055232249200344,
0.02851826325058937,
0.0003215945325791836,
-0.008829429745674133,
-0.014720149338245392,
0.038018159568309784,
-0.006048519164323807,
-0.015531610697507858,
0.02409970387816429,
0.010070810094475746,
0.00917691271752119,
0.009638703428208828,
0.02237667702138424,
-0.005465467926114798,
0.0013584435218945146,
0.01011718437075615,
0.0010273491498082876,
0.004625031258910894,
0.006984519772231579,
0.009257112629711628,
0.030682703480124474,
-0.002389211906120181,
-0.008246470242738724,
0.007255541160702705,
-0.011656682938337326,
0.0659368634223938,
0.011064253747463226,
0.025280097499489784,
0.006401865277439356,
0.04223170876502991,
-0.006643330678343773,
0.002422906458377838,
0.003988842014223337,
-0.00872949417680502,
0.0014420081861317158,
-0.011284664273262024,
0.014305601827800274,
0.009959998540580273,
0.022304974496364594,
-0.0034179999493062496,
-0.033461734652519226,
0.002240122063085437,
0.001720221247524023,
-0.0011776192113757133,
-0.014354942366480827,
-0.009318729862570763,
0.021176142618060112,
-0.005865704268217087,
0.002737074624747038,
-0.006978881545364857,
-0.0112229622900486,
0.0013267566682770848,
-0.006846818141639233,
0.00874609686434269,
0.000857076607644558,
0.015347452834248543,
-0.001227127155289054,
0.01354956068098545,
-0.009407331235706806,
-0.014082888141274452,
-0.022564705461263657,
0.008405748754739761,
-0.007984493859112263,
0.03291944041848183,
0.0009195359889417887,
-0.01145981252193451,
-0.00377642665989697,
-0.006520499009639025,
-0.02151593193411827,
0.004924167413264513,
-0.011920535936951637,
-0.024196375161409378,
0.009268461726605892,
0.00939953327178955,
-0.027613725513219833,
0.00953189842402935,
-0.005381026770919561,
0.010167460888624191,
-0.01507095992565155,
0.0013629620661959052,
0.03190635144710541,
-0.020799759775400162,
0.014661816880106926,
0.00821983627974987,
0.008215978741645813,
-0.017541754990816116,
-0.003787158289924264,
0.00802141334861517,
-0.0025917161256074905,
-0.0048108696937561035,
0.023795487359166145,
0.011452795937657356,
0.002397899515926838,
0.012119944207370281,
-0.018511584028601646,
-0.012553569860756397,
0.010571878403425217,
0.0321451872587204,
-0.0037078585010021925,
-0.014256387017667294,
0.01934005692601204,
-0.04405883327126503,
0.007259313482791185,
0.019556893035769463,
0.028334835544228554,
-0.01071702130138874,
0.0035812738351523876,
0.008379833772778511,
-0.031215663999319077,
0.01877162791788578,
0.0003649630816653371,
-0.020434675738215446,
-0.0008836914785206318,
0.021283574402332306,
0.0025278842076659203,
-0.0005171541124582291,
0.013502727262675762,
-0.010346908122301102,
-0.0010263968724757433,
-0.08143819868564606,
-0.011975407600402832,
0.004948480054736137,
0.010326601564884186,
0.00612983712926507,
-0.02184823527932167,
-0.000018543563783168793,
-0.005404326133430004,
-0.006690754555165768,
0.03735937550663948,
0.003648148151114583,
0.014539922587573528,
-0.006576244719326496,
-0.0029417253099381924,
0.028489749878644943,
0.0008941870764829218,
0.012112583965063095,
0.045652780681848526,
-0.010308932512998581,
-0.018743151798844337,
-0.0013235751539468765,
0.003005226608365774,
0.010632634162902832,
0.004296979866921902,
0.0013747189659625292,
-0.031322166323661804,
0.007348305080085993,
0.002872699638828635,
-0.005024023354053497,
-0.0029444387182593346,
-0.028145937249064445,
-0.002444350626319647,
-0.004286500625312328,
-0.0005166893824934959,
0.005973224528133869,
0.007018859498202801,
0.005467711016535759,
-0.0038449857383966446,
-0.0033610453829169273,
0.028284739702939987,
-0.02205640822649002,
0.014827780425548553,
0.004618980921804905,
-0.004931608214974403,
0.026316143572330475,
0.00030156481079757214,
0.017860235646367073,
0.04619418457150459,
0.023919198662042618,
0.01004934310913086,
0.026676082983613014,
-0.0015653923619538546,
0.00047969818115234375,
0.025111984461545944,
-0.01990097388625145,
0.002818916691467166,
-0.020906081423163414,
-0.010188568383455276,
-0.005793098360300064,
-0.008050786331295967,
-0.009466140531003475,
0.011754022911190987,
0.02059343457221985,
0.012952161952853203,
-0.037356965243816376,
0.017382141202688217,
0.007073121145367622,
0.014592782594263554,
-0.011330341920256615,
0.014382202178239822,
-0.03723573684692383,
0.0015274037141352892,
-0.012434069998562336,
-0.0009149557445198298,
0.00800251867622137,
-0.0032955948263406754,
-0.019291233271360397,
0.0026031460147351027,
-0.0071506863459944725,
0.0023788372054696083,
-0.023595958948135376,
0.02038649655878544,
-0.029669994488358498,
-0.001155479229055345,
-0.020356740802526474,
-0.01468932069838047,
0.004339586943387985,
0.0024442379362881184,
0.0016284179873764515,
-0.010177906602621078,
0.01029491238296032,
-0.00010822433978319168,
-0.0027582356706261635,
0.010611310601234436,
0.0031624766997992992,
-0.03465910255908966,
0.022214671596884727,
0.01566842384636402,
0.002208303427323699,
0.007920341566205025,
-0.005857556127011776,
-0.01918836683034897,
-0.020824681967496872,
-0.01155480183660984,
-0.02817598357796669,
0.014937000349164009,
-0.011299597099423409,
0.009269533678889275,
-0.016708672046661377,
0.003897988935932517,
0.038542602211236954,
-0.012476665899157524,
-0.007613237015902996,
-0.017113465815782547,
0.009884078055620193,
0.005748412571847439,
0.025205373764038086,
-0.015792623162269592,
0.07197517156600952,
0.0017784794326871634,
0.011238624341785908,
-0.011252875439822674,
0.011408939026296139,
-0.013835354708135128,
0.023525476455688477,
-0.006485103629529476,
-0.008560437709093094,
0.0045890044420957565,
0.015107313171029091,
-0.0072797504253685474,
0.0002639258746057749,
-0.0016619579400867224,
0.0048938593827188015,
0.01244431920349598,
-0.000019188039004802704,
-0.03208402171730995,
0.026145827025175095,
0.024579022079706192,
-0.014743129722774029,
-0.006403450854122639,
0.002315718214958906,
0.0024649123661220074,
0.035468973219394684,
-0.012476379983127117,
-0.0011412971653044224,
-0.009410803206264973,
0.011683040298521519,
0.011812724173069,
0.0163075290620327,
-0.029072558507323265,
-0.008431315422058105,
-0.016439449042081833,
0.02276577055454254,
0.04203234612941742,
0.014376585371792316,
0.04234052821993828,
-0.018852921202778816,
-0.021520428359508514,
-0.018190577626228333,
-0.013353170827031136,
0.0058484203182160854,
-0.0052306391298770905,
0.021215420216321945,
-0.002124480437487364,
-0.03724239766597748,
-0.010491950437426567,
0.0028554857708513737,
-0.005807209759950638,
0.009895211085677147,
0.004273157101124525,
0.009979918599128723,
0.008421855047345161,
-0.029270343482494354,
0.0079758670181036,
-0.0058541749604046345,
0.0019113350426778197,
0.00834544189274311,
-0.002731275511905551,
-0.02272878587245941,
-0.014719122089445591,
-0.01662351004779339,
-0.007158213760703802,
0.013196556828916073,
0.004341697320342064,
-0.004277550615370274,
0.01497327908873558,
0.014339208602905273,
0.0010934057645499706,
0.013959088362753391,
-0.009349443949759007,
0.005151805002242327,
-0.0018143067136406898,
-0.030915193259716034,
-0.0206147450953722,
-0.026444174349308014,
-0.007756936363875866,
0.005528121255338192,
-0.0018638675101101398,
-0.023283913731575012,
0.001998830121010542,
-0.022790376096963882,
-0.025312159210443497,
-0.016665127128362656,
-0.01231117732822895,
-0.017662018537521362,
-0.07585469633340836,
-0.018400045111775398,
-0.001270652748644352,
-0.0009112324914894998,
-0.014615220949053764,
-0.018850957974791527,
-0.029277650639414787,
-0.01748165674507618,
-0.006519659422338009,
-0.0007782954489812255,
0.008416709490120411,
0.004191594664007425,
0.00899607501924038,
0.008709236979484558,
0.014018633402884007,
0.015180119313299656,
-0.012555663473904133,
-0.003580984426662326,
-0.03624093905091286,
0.020392034202814102,
0.011508543975651264,
0.0030341199599206448,
-0.02453012764453888,
0.005523887928575277,
-0.015920640900731087,
-0.08090600371360779,
-0.011810628697276115,
-0.002175521571189165,
-0.005356488283723593,
0.003733661025762558,
-0.01907588168978691,
0.018032951280474663,
-0.004284974187612534,
0.02592463418841362,
-0.012082332745194435,
0.007449503988027573,
-0.01985085755586624,
-0.005670672282576561,
0.005986018572002649,
-0.000029558315873146057,
-0.008845852687954903,
0.0051347375847399235,
-0.0138537073507905,
-0.0038637479301542044,
0.0023411745205521584,
0.00850406289100647,
0.02660324051976204,
-0.00636550597846508,
-0.00959850288927555,
-0.0019305543974041939,
-0.01186385564506054,
-0.021884102374315262,
0.010079555213451385,
-0.015157828107476234,
-0.006132759153842926,
-0.0017789347330108285,
-0.0013610911555588245,
-0.017625829204916954,
-0.020352669060230255,
0.006940263323485851,
-0.03715333342552185,
0.02722202241420746,
0.005766944959759712,
0.010614756494760513,
0.0028161308728158474,
-0.008126147091388702,
0.001208712812513113,
-0.01009850949048996,
0.007860811427235603,
-0.0016667494783177972,
0.005281236954033375,
0.008028805255889893,
-0.015166412107646465,
0.028943005949258804,
0.02516687661409378,
-0.0009171633282676339,
-0.009593421593308449,
0.009327209554612637,
0.010966062545776367,
0.017688319087028503,
0.0018480289727449417,
-0.004082792904227972,
0.02590620517730713,
-0.023889221251010895,
0.006873471662402153,
0.006324823945760727,
-0.019707627594470978,
0.019094154238700867,
0.07094462215900421,
-0.01875772327184677,
0.009979499503970146,
0.0006753937341272831,
-0.0040138945914804935,
0.0056128972209990025,
0.01671568676829338,
0.012049519456923008,
-0.019686955958604813,
-0.0117931067943573,
0.014066813513636589,
0.005523535422980785,
-0.025623315945267677,
0.011130932718515396,
-0.0036985729821026325,
-0.026289021596312523,
0.0133414501324296,
0.012559707276523113,
-0.0002615610137581825,
0.022419394925236702,
0.0006595451850444078,
0.0035215148236602545,
-0.01245979405939579,
-0.00449394341558218,
0.001956308027729392,
-0.011331124231219292,
-0.03732768073678017,
-0.004418228752911091,
0.0015836525708436966,
0.0042330240830779076,
-0.01009697001427412,
0.024629447609186172,
0.002534302417188883,
0.018195975571870804,
0.0024147743824869394,
0.005894841160625219,
-0.010567324236035347,
0.017060406506061554,
0.01661074534058571,
0.006323679815977812,
-0.024067729711532593,
0.004893241450190544,
-0.004775547422468662,
-0.024101734161376953,
0.011128981597721577,
-0.024582885205745697,
-0.02545062080025673,
-0.006904467940330505,
0.007976887747645378,
0.005451007280498743,
0.024335261434316635,
0.009009012952446938,
0.02205999568104744,
0.002204665681347251,
0.010086160153150558,
0.022449210286140442,
-0.03894282132387161,
0.019524209201335907,
0.001289217034354806,
-0.018436942249536514,
0.00016693840734660625,
-0.018629245460033417,
0.001620658440515399,
-0.020684976130723953,
0.014951582998037338,
-0.009029949083924294,
0.015214694663882256,
-0.004931269679218531,
-0.023944701999425888,
0.006991248577833176,
-0.005738430190831423,
-0.002269919030368328,
0.00769939785823226,
0.01629449799656868,
0.008843629620969296,
0.003111307043582201,
0.009260397404432297,
-0.01190318912267685,
0.015878941863775253,
0.009310383349657059,
-0.008748159743845463,
-0.0008896971121430397,
0.009541935287415981,
0.029276590794324875,
0.0035665123723447323,
0.002913679927587509,
0.014944967813789845,
-0.0045132082886993885,
0.0005798732163384557,
0.005910892970860004,
0.008997384458780289,
-0.011932656168937683,
0.0017678921576589346,
0.00832987017929554,
0.005992416758090258,
0.03636036813259125,
-0.015878990292549133,
0.005867780186235905,
0.012942278757691383,
-0.010228636674582958,
0.022049691528081894,
0.011290921829640865,
-0.03137004375457764,
0.014832669869065285,
0.01630687713623047,
0.0031740895938128233,
-0.012044981122016907,
0.023519955575466156,
0.008753702044487,
0.02305143140256405,
0.005003512836992741,
0.009618373587727547,
0.013805818744003773,
-0.007905406877398491,
-0.007622882258147001,
-0.00578727200627327,
-0.004850777797400951,
-0.008916488848626614,
-0.02423275262117386,
-0.017074400559067726,
-0.035878267139196396,
-0.0058530168607831,
-0.015771273523569107,
0.02963036485016346,
-0.015118991956114769,
0.00024401536211371422,
-0.012804733589291573,
-0.00914018228650093,
0.0008934624493122101,
0.009150254540145397,
0.026485273614525795,
-0.011561712250113487,
-0.019004713743925095,
-0.019410988315939903,
-0.02511315979063511,
-0.013400275260210037,
-0.015386628918349743,
0.012726978398859501,
-0.007218256592750549,
0.0000777319073677063,
0.01088637299835682,
0.00822936836630106,
0.007394312880933285,
-0.012055940926074982,
0.008102500811219215,
-0.02375156618654728,
0.03019244410097599,
0.02556636370718479,
0.010463105514645576,
0.013851485215127468,
0.006064772605895996,
-0.005545996129512787,
-0.006435154005885124,
-0.004179601091891527,
0.022062424570322037,
0.004971526563167572,
0.0036856113001704216,
-0.023941099643707275,
-0.017141375690698624,
0.0061048357747495174,
0.0014530004700645804,
-0.006876034662127495,
0.018432553857564926,
-0.0026453938335180283,
0.020870983600616455,
0.014833521097898483,
0.001287013990804553,
-0.009506508708000183,
-0.008354288525879383,
0.018836218863725662,
0.011581545695662498,
0.008918768726289272,
0.0151335708796978,
-0.0012539948802441359,
-0.021164806559681892,
-0.006963305175304413,
-0.005265553016215563,
-0.023199692368507385,
0.007325494196265936,
0.020125482231378555,
0.0293811596930027,
-0.0005862647667527199,
0.007254166062921286,
-0.013840588741004467,
0.019783977419137955,
-0.018167026340961456,
-0.009028836153447628,
0.013108757324516773,
-0.00514978589490056,
0.00820180494338274,
-0.023379622027277946,
-0.01934318244457245,
-0.010576048865914345,
-0.0050520505756139755,
-0.0314088836312294,
0.003465592162683606,
0.004554519429802895,
-0.03403416648507118,
0.016224287450313568,
0.026003452017903328,
0.025829534977674484,
-0.01435973308980465
] | [
0.02347761020064354,
0.3469011187553406,
0.05967205390334129,
0.16642025113105774,
0.024111082777380943,
-0.08682824671268463,
0.5678896307945251,
-0.25520896911621094,
0.2764432430267334,
0.3577881455421448,
0.41009560227394104,
0.395559161901474,
-0.14410121738910675,
0.22518213093280792,
0.06796383112668991,
0.5207333564758301,
0.4518688917160034,
0.5400328040122986,
0.11752051115036011,
-0.8490980863571167,
-0.22837421298027039,
-0.5197347402572632,
1.0205994844436646,
0.19280266761779785,
0.2639882564544678,
0.2595357298851013,
-0.019707102328538895,
0.22381314635276794,
-0.15357299149036407,
-0.16974806785583496,
0.12498582154512405,
1.0593067407608032,
0.12184462696313858,
-0.5022329688072205,
0.18614251911640167,
0.29103991389274597,
0.3652198910713196,
0.1742209494113922,
-0.1888694316148758,
-0.8697590231895447,
-0.2534258961677551,
-0.06763757020235062,
0.01780496910214424,
0.3294413387775421,
-0.3160366714000702,
-0.16503655910491943,
-1.1548346281051636,
0.7956786751747131,
-0.5699490308761597,
0.2728736102581024,
0.1975218951702118,
0.16008935868740082,
1.2977519035339355,
-0.3117034137248993,
0.20449070632457733,
0.8897706866264343,
-0.9481803178787231,
0.034173429012298584,
0.3310476541519165,
-0.14528349041938782,
-0.5403225421905518,
-0.02160494774580002,
-0.2384355217218399,
-0.21686458587646484,
0.09620524197816849,
0.3675340712070465,
-0.022575441747903824,
-0.5551985502243042,
-0.3040500581264496,
-0.08689006417989731,
0.5256310105323792,
-0.2833038568496704,
-0.30596157908439636,
0.756508469581604,
-0.16644471883773804,
-0.1110631600022316,
-0.9114461541175842,
-0.08711763471364975,
-0.14401115477085114,
0.3062684237957001,
0.3405170738697052,
0.011481983587145805,
0.2948160469532013,
-0.13498012721538544,
-0.12644705176353455,
-0.041338954120874405,
0.35825276374816895,
0.8182778358459473,
-0.3198626637458801,
-0.33947688341140747,
-0.32942530512809753,
0.08655032515525818,
0.3979407548904419,
0.20335504412651062,
-0.15489979088306427,
-0.13344961404800415,
-0.26181644201278687,
-0.3702457845211029,
0.10702133178710938,
0.40908002853393555,
-0.15198875963687897,
0.02966172993183136,
-0.11833304166793823,
-0.13955500721931458,
-0.29570525884628296,
0.2164583057165146,
-1.0035187005996704,
-0.5160794854164124,
-0.4701881408691406,
0.09123919904232025,
-0.31022411584854126,
0.5579312443733215,
-0.24571989476680756,
0.06953933089971542,
-0.35308340191841125,
0.09140552580356598,
0.2267872393131256,
-0.0025912958662956953,
-0.26457107067108154,
0.14532321691513062,
-0.029682407155632973,
1.0938372611999512,
0.21292199194431305,
0.23795492947101593,
-0.12500734627246857,
0.0028182959649711847,
0.23715823888778687,
-0.06040077283978462,
-0.1314120590686798,
0.9172382950782776,
0.14279744029045105,
0.5853061676025391,
0.08375554531812668,
0.14436185359954834,
-0.05262817069888115,
-0.9186015129089355,
0.10786410421133041,
0.0979711264371872,
0.6748578548431396,
0.3608528971672058,
-0.5954078435897827,
-0.3749013841152191,
0.03091750666499138,
-0.21973825991153717,
-0.1277664303779602,
-0.06438837200403214,
-0.06090226024389267,
-0.15039072930812836,
-0.1828821450471878,
-0.0735425353050232,
0.4859012961387634,
-0.04837636649608612,
-0.4689907133579254,
0.23945364356040955,
0.2070397138595581,
0.6073161363601685,
-0.15424008667469025,
0.17571745812892914,
-0.1580979973077774,
-0.11602327227592468,
-0.0821492150425911,
0.0915812999010086,
0.31606584787368774,
0.07198220491409302,
0.29031771421432495,
0.10482673346996307,
-0.17039570212364197,
0.7928299307823181,
0.14991867542266846,
0.006915613077580929,
-0.037805020809173584,
-0.40345194935798645,
-0.4339815080165863,
-0.4584481120109558,
0.3209165930747986,
-0.06995569169521332,
-0.20504158735275269,
0.10579808056354523,
0.15973518788814545,
0.2278711348772049,
-0.49474889039993286,
1.190171718597412,
-0.20956052839756012,
-0.4940216839313507,
0.26034894585609436,
0.5406650304794312,
0.9667335152626038,
0.2929084002971649,
0.48603111505508423,
0.11757154017686844,
-0.4020828604698181,
-0.43122145533561707,
0.36413639783859253,
-0.7039925456047058,
1.332862138748169,
0.044364627450704575,
-0.31746846437454224,
0.46835994720458984,
0.2294338494539261,
-0.36870503425598145,
0.16987468302249908,
0.505702018737793,
0.09252943843603134,
-0.8481993675231934,
-0.9259281158447266,
-0.2752055823802948,
0.15920256078243256,
-0.23280487954616547,
0.40126898884773254,
0.17823940515518188,
0.26046842336654663,
-0.22341115772724152,
-0.3342319130897522,
-0.2684566378593445,
0.1411697417497635,
-0.012834797613322735,
-0.0676136165857315,
0.4220116436481476,
0.40392395853996277,
0.4850601851940155,
0.5755411982536316,
-0.6366448998451233,
0.22213923931121826,
1.1018232107162476,
-0.2528640031814575,
0.6549477577209473,
0.31378886103630066,
-0.3357446491718292,
0.3720022439956665,
0.15700535476207733,
0.5839963555335999,
-0.27601030468940735,
0.2500839829444885,
0.024989478290081024,
0.07658909261226654,
0.21407738327980042,
0.3831464648246765,
-0.06169423088431358,
0.5131831765174866,
-0.4432888329029083,
-0.2163877934217453,
0.1331384927034378,
-0.3726215362548828,
0.16832631826400757,
0.0656290277838707,
-0.19781965017318726,
-0.5602684617042542,
0.14980553090572357,
-0.6582962274551392,
-0.20287039875984192,
0.29470810294151306,
0.35681620240211487,
-0.22617897391319275,
-0.03393286466598511,
-0.06028563901782036,
-0.08752688020467758,
-0.7037067413330078,
0.06885115802288055,
0.31622013449668884,
0.4302715063095093,
-0.5972278118133545,
-0.2835155129432678,
0.4352872371673584,
0.3159162998199463,
0.09772282838821411,
0.12787729501724243,
-0.472453236579895,
-0.6253688931465149,
0.8226878643035889,
0.14425891637802124,
0.46542856097221375,
-0.36297523975372314,
-0.6875460743904114,
-0.15871211886405945,
-0.17927215993404388,
-0.23300214111804962,
-0.498203843832016,
0.45983171463012695,
-1.1724127531051636,
-0.251349538564682,
-0.09333620965480804,
0.8025162220001221,
0.26212021708488464,
-0.32447007298469543,
-0.5414860248565674,
-0.3592431843280792,
-0.3657151162624359,
-0.6162195205688477,
-0.17713795602321625,
-0.4915628433227539,
-0.03152209892868996,
0.3115554451942444,
-0.7243230938911438,
-0.19402118027210236,
-0.12011122703552246,
-0.0580228790640831,
0.3602305054664612,
1.0306943655014038,
0.6821548342704773,
-0.5073519349098206,
0.028709327802062035,
0.22489576041698456,
-0.7072296142578125,
0.15952667593955994,
-0.1355886161327362,
-0.18601511418819427,
-0.15801794826984406,
-0.23357443511486053,
-5.83154821395874,
0.14553043246269226,
-0.4404655396938324,
0.015750868245959282,
0.14631904661655426,
0.04273606091737747,
0.8582246899604797,
-0.4672681987285614,
0.24811047315597534,
0.41637223958969116,
0.10441279411315918,
0.5853809118270874,
0.5611770153045654,
-0.0035612783394753933,
-0.04005858674645424,
0.16076216101646423,
-0.11436019092798233,
-0.5667203664779663,
0.7701694965362549,
0.3696785271167755,
0.4130203425884247,
0.055837128311395645,
-0.02348199114203453,
0.6702219843864441,
0.18793484568595886,
-0.2269660085439682,
-0.1965988278388977,
0.49392226338386536,
-0.2115720510482788,
0.1515333354473114,
-0.2667838931083679,
-0.2005346268415451,
-0.023167887702584267,
-0.21287000179290771,
0.45195114612579346,
0.2307005077600479,
0.47280943393707275,
-0.42757123708724976,
0.03896580636501312,
-0.4267900884151459,
0.302024245262146,
-0.0055489204823970795,
0.37939077615737915,
-0.05569182336330414,
0.46464821696281433,
0.28382912278175354,
0.21039900183677673,
-0.5323976278305054,
-0.06589530408382416,
0.9973363280296326,
0.1732613891363144,
0.10717105865478516,
0.5300918221473694,
-0.16493955254554749,
-0.07782374322414398,
0.5634636282920837,
-0.11721358448266983,
-0.31498318910598755,
-0.2585241198539734,
0.0961013212800026,
-0.13751398026943207,
-0.00010396275320090353,
-0.3875231146812439,
-0.22125357389450073,
-0.25071296095848083,
0.09601638466119766,
-0.6076831817626953,
-0.3145202398300171,
0.04946789890527725,
-0.7051928043365479,
-0.5296908617019653,
-0.3071194589138031,
-0.2826453149318695,
-0.5710878372192383,
0.37462618947029114,
-0.6919842958450317,
0.31338706612586975,
0.12322023510932922,
-0.06037933751940727,
0.5480228662490845,
-0.7558076977729797,
-0.08545524626970291,
0.06606686860322952,
-0.11125825345516205,
0.6645196080207825,
0.0238336194306612,
0.011275294236838818,
-0.8051620721817017,
-0.5329638719558716,
0.11742040514945984,
0.24150626361370087,
-0.5751969814300537,
0.44044730067253113,
0.14989188313484192,
0.45984798669815063,
0.5809996724128723,
0.2194076031446457,
0.29595044255256653,
0.441770076751709,
0.040170811116695404,
0.7207775712013245,
-0.02012789063155651,
0.17840537428855896,
-0.2735760807991028,
0.18839707970619202,
-0.5169335603713989,
-0.367405503988266,
-0.08353808522224426,
0.4613915979862213,
-0.8012205958366394,
-0.05306844785809517,
0.2916587293148041,
-0.34302616119384766,
-0.08681513369083405,
0.47983255982398987,
0.008505127392709255,
0.07650505006313324,
0.15579427778720856,
0.8334426283836365,
-0.19549883902072906,
0.08541245013475418,
0.47269803285598755,
-0.32274654507637024,
-0.11801735311746597,
0.24325953423976898,
-0.6261181831359863,
-0.028335655108094215,
0.5215694308280945,
-0.2320479452610016,
0.33990782499313354,
-0.010365416295826435,
-0.5223192572593689,
-0.674561083316803,
-0.20081515610218048,
0.3613135516643524,
-0.02993047423660755,
-0.653523862361908,
-0.1906682699918747,
-0.24284929037094116,
-0.41016697883605957,
0.06401830166578293,
-0.6673019528388977,
-0.47009894251823425,
0.14867927134037018,
0.4719744920730591,
-0.03902261704206467,
-0.17082029581069946,
-0.3269013464450836,
-0.32873862981796265,
-0.20041069388389587,
0.08976933360099792,
0.35160380601882935,
0.14562547206878662,
-0.16355399787425995,
-0.3891143500804901,
-0.19023463129997253,
0.3906296193599701,
0.5801038146018982,
0.1397499293088913,
-0.48415830731391907,
0.2730443775653839,
0.005398856475949287,
-0.7650891542434692,
-0.07364577054977417,
-0.26182255148887634,
-0.3550991714000702,
0.1719638854265213,
0.05633234605193138,
-0.45151951909065247,
0.3864309787750244,
0.24277378618717194,
-0.3401947319507599,
0.13457906246185303,
0.24007877707481384,
-0.023374097421765327,
0.3023217022418976,
-0.027893250808119774,
-0.20314957201480865,
0.005010497290641069,
-0.1656992882490158,
-0.08607335388660431,
-0.48118066787719727,
-0.20018337666988373,
0.7169545888900757,
0.45854103565216064,
-0.04119258001446724,
0.03466550260782242,
-0.5910242795944214,
-0.34937813878059387,
0.17213019728660583,
0.3740104138851166,
-0.014339063316583633,
0.22536568343639374,
-0.12366597354412079,
-0.10016202926635742,
-0.45140671730041504,
0.006532410625368357,
0.25084570050239563,
-0.2465764433145523,
0.05929798632860184,
0.3272586762905121,
0.17421947419643402,
-0.3055596351623535,
0.1548236608505249,
0.03702439367771149,
-0.3822113573551178,
-0.5231917500495911,
-0.03725016117095947,
-0.2757960259914398,
-0.4953327178955078,
0.23286297917366028,
-0.26999691128730774,
0.6492020487785339,
0.37025558948516846,
-0.15999144315719604,
0.1963701695203781,
0.23385202884674072,
-0.4206097424030304,
-0.3068471848964691,
-0.2041073739528656,
0.7804591655731201,
-0.2330295592546463,
-0.24524036049842834,
-0.40247246623039246,
-0.5057148337364197,
0.09439805895090103,
0.7517204284667969,
-0.5448426604270935,
-0.0686851516366005,
0.3644012212753296,
0.09703963994979858,
-0.18500317633152008,
0.03274429589509964,
0.05809556320309639,
0.01950090192258358,
0.4469256103038788,
-0.36211663484573364,
0.2099418342113495,
0.09246024489402771,
-0.09208960831165314,
-0.06362154334783554,
0.39453408122062683,
-0.06674918532371521,
0.14593839645385742,
-0.4259013533592224,
0.6351497769355774,
0.1231553852558136,
-0.22298550605773926,
-0.5983418226242065,
-0.024369841441512108,
0.7570745348930359,
0.04334675893187523,
0.2805972695350647,
-0.2529633045196533,
0.601622462272644,
-0.040125083178281784,
0.19946737587451935,
-0.11417967081069946,
-0.21695926785469055,
0.615425169467926,
-0.5348719954490662,
0.20664295554161072,
-0.3676891028881073,
-0.0637921541929245,
0.40517425537109375,
-0.16329818964004517,
-0.36002829670906067,
-0.5968032479286194,
0.021016279235482216,
-0.4772964119911194,
-0.4534970223903656,
-0.3147280812263489,
-0.10510048270225525,
0.2728998064994812,
-0.12289509177207947,
0.2582802176475525,
-0.157857283949852,
-0.5099839568138123,
-0.033186525106430054,
0.009301496669650078,
-0.7472110986709595,
-0.4248553514480591,
-0.4240563213825226,
0.06677837669849396,
0.1636112481355667,
-0.18445514142513275,
-0.24987825751304626,
-0.3974056839942932,
-0.568193256855011,
-0.1450621485710144,
0.0886678546667099,
0.34733080863952637,
-0.682574450969696,
-0.2719278633594513,
0.20302312076091766,
0.3135365843772888,
0.20296308398246765,
0.23312677443027496,
-0.32091838121414185,
-0.1297009140253067,
-0.3536405861377716,
0.19033575057983398,
1.2025738954544067,
-0.7921181321144104,
-0.4831424057483673,
0.3383162021636963,
0.27062559127807617,
-0.4099313020706177,
-0.0311497263610363,
-0.4589422345161438,
0.27140507102012634,
-0.13260197639465332,
-0.14110490679740906,
-0.07562769204378128,
0.016673024743795395,
0.32167595624923706,
0.3538067638874054,
0.012750163674354553,
0.348653644323349,
0.7331048846244812,
1.1515032052993774,
-0.28369203209877014,
0.36329999566078186,
-0.2803818881511688,
0.2620076835155487,
0.35716626048088074,
0.28323692083358765,
-0.31646841764450073,
-0.3120775520801544,
0.5901700258255005,
0.6601454019546509,
0.5055015683174133,
-0.3106845021247864,
-0.003198730992153287,
0.14435610175132751,
0.07840582728385925,
-0.4223282039165497,
-0.17582441866397858,
-0.334044486284256,
0.32475754618644714,
1.1881308555603027,
0.36513128876686096,
-0.28355902433395386,
-0.13729463517665863,
0.6643370985984802,
-0.03019900806248188,
0.549304723739624,
-0.33620208501815796,
-0.31171947717666626,
0.07251007109880447,
0.2982349991798401,
0.149186909198761,
-0.38369181752204895,
-0.3100113868713379,
-0.7767167091369629,
-0.1940688192844391,
-0.007715244311839342,
0.07612039893865585,
-0.436832070350647,
0.26745834946632385,
-0.1545325368642807,
0.27147310972213745,
-0.3466726541519165,
0.42184630036354065,
0.19428806006908417,
0.14837799966335297,
-0.054408784955739975,
-0.125239759683609,
-0.24009844660758972,
0.024267619475722313,
-0.5480721592903137,
-0.48565030097961426,
-0.8977531790733337,
0.3658951222896576,
0.2877461612224579,
-0.532011866569519,
0.014012991450726986,
-0.12847758829593658,
0.5467691421508789,
0.4274287819862366,
-0.5611248016357422,
0.387986958026886,
-0.4011813700199127,
-0.12580260634422302,
-0.18943695724010468,
0.014309297315776348,
-0.42488783597946167,
0.24304571747779846,
-0.37641945481300354,
0.09979049116373062,
0.16164813935756683,
0.04001627489924431,
0.2132529318332672,
0.07206796854734421,
0.1275051087141037,
-0.08077506721019745,
-0.026919487863779068,
0.35770183801651,
-0.06478134542703629,
0.038572948426008224,
-0.09476486593484879,
0.25942084193229675,
0.0339348204433918,
0.23250366747379303,
-0.4537787139415741,
0.44709813594818115,
-0.9801482558250427,
0.1287682056427002,
-0.3407535254955292,
0.11324161291122437,
0.5300579071044922,
0.47523942589759827,
-0.37192502617836,
-0.3062323331832886,
0.11103005707263947,
0.11519496887922287,
-0.21477298438549042,
-0.5768913626670837,
0.02894110605120659,
-0.6636484265327454,
-0.4962702989578247,
0.058067236095666885,
0.7125566005706787,
0.1460629552602768,
-0.37180936336517334,
-0.11361447721719742,
0.04684559628367424,
0.33952170610427856,
-0.4017355740070343,
0.28141292929649353,
0.5997464060783386,
0.4471105933189392,
-0.13883453607559204,
0.6621688604354858,
-0.33200696110725403,
0.15473660826683044,
-0.4749235510826111,
0.3824373781681061,
-0.3614675998687744,
0.13140258193016052,
-0.0023798251058906317,
-0.23197413980960846,
-0.1632297784090042,
0.006818035151809454,
0.1798265278339386,
0.014479371719062328,
0.02861948125064373,
-0.36821249127388,
-1.13007390499115,
0.001193827367387712,
-0.22123777866363525,
-0.6625791192054749,
-0.3633062541484833,
0.38775020837783813,
0.01391533762216568,
-0.5914590358734131,
0.0054785823449492455,
-0.48977768421173096,
0.05107251927256584,
-0.20142728090286255
] |
BACKGROUND: The HIV epidemic poses significant challenges to the low income countries in sub Saharan Africa (SSA), affecting the attrition rate among health care workers, their level of motivation, and absenteeism from work. Little is known about how to deal with deterioration of human resources in the health care systems. This study aimed to predict the intention to provide surgical treatment to HIV infected patients among medical- and dental students in Tanzania and Sudan using an extended version of the Theory of Planned Behaviour (TPB). METHODS: Four hundred and seventy five medical- and dental students at the University of Dar es Salaam (mean age, 25 yr) and 642 dental students attending 6 public and private dental faculties in Khartoum (mean age 21.7 yr) completed self-administered TPB questionnaires in 2005 and 2007, respectively. RESULTS: Both Tanzanian and Sudanese students demonstrated strong intentions to provide care for people with HIV and AIDS. Stepwise linear regression revealed that the TPB accounted for 51% (43% in Tanzania and Sudan) of the variance in intention across study sites. After having controlled for country and past behaviour, the TPB in terms of attitudes, subjective norms and perceived behavioural control accounted for 34% and moral norms for an additional 2,3% of the explainable variance in intention. Across both study sites, attitudes were the strongest predictor of intention followed in descending order by subjective norms, moral norms and perceived behavioural control. CONCLUSION: The TPB is applicable to students' care delivery intentions in the context of HIV and AIDS across the two SSA countries investigated. It is suggested that attitudes, subjective norms, moral norms and perceived behavioural control are key factors in students' willingness to treat AIDS and HIV infected patients and should be targets of interventions aimed at improving the quality of health care delivery in this context. | [
0.010254127904772758,
0.0151877012103796,
0.005175809841603041,
0.009070453234016895,
0.011270730756223202,
0.005803844425827265,
0.008030340075492859,
0.014474617317318916,
-0.012469640001654625,
-0.04022468253970146,
-0.016979891806840897,
0.016188137233257294,
-0.026259759441018105,
0.025561941787600517,
-0.012469468638300896,
-0.002322512213140726,
-0.015225406736135483,
0.00387248070910573,
0.008824581280350685,
0.013949695974588394,
0.0002997813280671835,
-0.005848183296620846,
0.01008327305316925,
0.00020537653472274542,
-0.007879388518631458,
0.014617154374718666,
-0.0077874683775007725,
-0.027445098385214806,
0.014499501325190067,
0.018194153904914856,
0.004642129875719547,
0.03395415097475052,
0.011348632164299488,
0.009130064398050308,
0.00577237643301487,
-0.0038568037562072277,
0.0014380741631612182,
0.02517455816268921,
-0.005774880293756723,
-0.0030073875095695257,
0.02336161769926548,
-0.008374602533876896,
0.0017762352945283055,
-0.018647750839591026,
-0.0075015416368842125,
0.025700116530060768,
-0.005307934246957302,
-0.002592145698145032,
-0.010488414205610752,
0.010125023312866688,
0.005111643113195896,
-0.022174648940563202,
-0.009983854368329048,
-0.03237973898649216,
-0.006056751124560833,
0.0025588897988200188,
0.018839042633771896,
0.024082176387310028,
-0.03326866030693054,
0.00947968102991581,
-0.003808841574937105,
0.027528539299964905,
0.004155059810727835,
-0.00433307234197855,
0.008108187466859818,
-0.06713712215423584,
-0.0034912889823317528,
0.0012014023959636688,
-0.0002927238820120692,
-0.008862457238137722,
0.017380954697728157,
0.007449454627931118,
0.03516919165849686,
0.011586601845920086,
-0.02555997110903263,
-0.0030915099196135998,
0.006678486708551645,
0.01995917037129402,
0.011490557342767715,
0.0012022941373288631,
0.0056579336524009705,
0.019226334989070892,
0.004004533402621746,
0.02015778049826622,
-0.014320837333798409,
-0.016284938901662827,
-0.015189109370112419,
-0.005947659723460674,
0.0014531915076076984,
-0.037348467856645584,
0.021547429263591766,
-0.010823087766766548,
-0.03095470368862152,
0.002994163893163204,
-0.008893960155546665,
-0.018064800649881363,
-0.007849171757698059,
0.003360109869390726,
-0.006478648632764816,
-0.004856474697589874,
0.0031740209087729454,
-0.005060170777142048,
0.017827073112130165,
0.03824201226234436,
0.03054235875606537,
0.008785032667219639,
-0.02102605439722538,
0.00481670955196023,
-0.001280603464692831,
0.0003347570891492069,
0.019442543387413025,
0.008116411045193672,
0.0017276951111853123,
-0.0044984472915530205,
-0.0007596297655254602,
0.00022808241192251444,
-0.007512680254876614,
-0.005550033878535032,
0.010293091647326946,
0.004837576299905777,
0.007333874702453613,
-0.014643441885709763,
-0.0012877797707915306,
0.0072394791059195995,
0.0007549112197011709,
0.0032091690227389336,
-0.011645213700830936,
-0.0017611775547266006,
-0.014263603836297989,
-0.005835153628140688,
-0.0027915597893297672,
0.008189819753170013,
0.008350124582648277,
-0.0004602661356329918,
-0.006835159845650196,
0.006788067985326052,
-0.002582165412604809,
0.025783902034163475,
-0.011169984936714172,
-0.003798055462539196,
-0.0017262483015656471,
0.004925301764160395,
-0.010383392684161663,
0.005641249008476734,
-0.013106558471918106,
-0.0019188313744962215,
-0.01762998290359974,
0.000950403802562505,
0.004512010607868433,
-0.012291167862713337,
0.016087893396615982,
0.006010762415826321,
-0.0024352436885237694,
-0.01701391115784645,
-0.0020243634935468435,
-0.008383024483919144,
-0.022453028708696365,
-0.02241099253296852,
-0.0033052454236894846,
-0.018205560743808746,
-0.037177108228206635,
-0.006385458633303642,
-0.0008435834897682071,
0.007701129652559757,
0.013358643278479576,
-0.010235484689474106,
-0.0013793832622468472,
-0.011844731867313385,
0.0036013163626194,
0.001959898043423891,
-0.0073551819659769535,
-0.0014547784812748432,
-0.01559800747781992,
0.00620941910892725,
-0.011005529202520847,
-0.004334849305450916,
-0.01354731060564518,
0.006318655330687761,
0.0033864660654217005,
0.06645475327968597,
-0.0012655672617256641,
0.000589137664064765,
-0.014415731653571129,
0.011332467198371887,
0.000788401230238378,
0.005823776125907898,
0.014557885006070137,
0.00037382275331765413,
0.011311715468764305,
0.029304642230272293,
-0.014700914733111858,
-0.02106647565960884,
-0.01663392037153244,
0.001774532487615943,
-0.013018766418099403,
0.0031880741007626057,
0.020183201879262924,
0.005906601902097464,
0.004639185965061188,
0.004189876839518547,
-0.01783548854291439,
-0.005170136224478483,
0.019851960241794586,
0.009099992923438549,
-0.028089232742786407,
0.009244218468666077,
0.0270344577729702,
-0.0064647383987903595,
-0.006488046143203974,
-0.03372734785079956,
0.02166571095585823,
-0.01366446353495121,
0.022249849513173103,
0.0005280021578073502,
-0.02444200962781906,
0.006954454816877842,
0.025364182889461517,
0.02287026308476925,
-0.0030234188307076693,
-0.013630695641040802,
-0.006894850172102451,
0.003992507234215736,
-0.016244370490312576,
0.016695477068424225,
0.005990367382764816,
-0.019588874652981758,
-0.0029964610002934933,
0.01291736215353012,
-0.003483668901026249,
0.0034586340188980103,
-0.015209170058369637,
-0.017115194350481033,
-0.0074519445188343525,
-0.0138357849791646,
0.0014328293036669493,
0.0033031797502189875,
0.012701192870736122,
0.009638862684369087,
0.014640347100794315,
-0.01693512126803398,
0.001091012149117887,
-0.017890173941850662,
0.017564531415700912,
0.007941380143165588,
-0.004028007388114929,
-0.0014624764444306493,
-0.006879542488604784,
0.012052186764776707,
-0.025593891739845276,
-0.002404113532975316,
0.0068351817317306995,
-0.016980279237031937,
-0.002811908721923828,
0.013068826869130135,
0.03184026479721069,
-0.010223637335002422,
0.006631670985370874,
-0.03726985678076744,
0.024487361311912537,
-0.03614058718085289,
0.010880941525101662,
0.005322928540408611,
0.008279524743556976,
-0.013486161828041077,
0.005014851223677397,
-0.02126673236489296,
0.005887338891625404,
0.006280309520661831,
-0.002309137023985386,
0.016580723226070404,
0.00349521660245955,
-0.006527742370963097,
0.00899115763604641,
-0.0816766619682312,
-0.01144959032535553,
-0.004506015218794346,
-0.01565036177635193,
0.007827906869351864,
0.00399722158908844,
0.004710538778454065,
0.01921246387064457,
-0.015443704091012478,
-0.0017289749812334776,
0.007868954911828041,
0.023618215695023537,
-0.004715532995760441,
-0.03443514555692673,
-0.0016275481320917606,
0.0015109831001609564,
0.0000381123973056674,
0.009890863671898842,
-0.0008741072379052639,
0.007754988968372345,
-0.018210001289844513,
-0.003804889041930437,
0.03285302594304085,
-0.0014025100972503424,
-0.0008489722386002541,
0.004261377267539501,
0.016849298030138016,
0.011565896682441235,
0.0012859837152063847,
0.012139763683080673,
0.01311053428798914,
-0.0071283322758972645,
-0.010669495910406113,
-0.033404283225536346,
-0.015405435115098953,
-0.004878143779933453,
-0.011566008441150188,
-0.013580040074884892,
-0.025373097509145737,
0.008847898803651333,
0.024428892880678177,
0.0034433812834322453,
0.020695699378848076,
-0.001885449979454279,
0.006669942755252123,
-0.003443323075771332,
0.007161274552345276,
0.004634005483239889,
0.011164743453264236,
0.019176466390490532,
-0.00612601637840271,
-0.0060971383936703205,
0.012608155608177185,
0.014670046977698803,
-0.004113853443413973,
-0.01933654397726059,
-0.010919678956270218,
0.006898724474012852,
-0.005619017872959375,
-0.016320019960403442,
-0.009144335985183716,
0.006167346611618996,
0.01623421162366867,
-0.007003421429544687,
-0.015180893242359161,
0.009241377003490925,
0.013857629150152206,
0.008639161475002766,
-0.008554510772228241,
-0.0069044497795403,
-0.008355286903679371,
0.00018036388792097569,
0.008863984607160091,
-0.006443864665925503,
-0.005318745505064726,
-0.002338949590921402,
-0.01815371960401535,
0.0046420651488006115,
0.022422580048441887,
0.012524401769042015,
-0.010529663413763046,
0.0047810813412070274,
-0.021337032318115234,
-0.00145255820825696,
0.004789638798683882,
0.02074975147843361,
0.00960833765566349,
0.004531909245997667,
0.010063787922263145,
-0.01806885004043579,
-0.008027329109609127,
-0.009422583505511284,
0.002953033661469817,
0.00671278964728117,
0.007768400013446808,
-0.03406904637813568,
0.012866942211985588,
0.013065258041024208,
-0.0038106294814497232,
0.008119952864944935,
-0.004252411425113678,
-0.007960526272654533,
-0.012615473009645939,
-0.009145241230726242,
-0.013330847024917603,
0.01882319524884224,
0.017383577302098274,
-0.0021617822349071503,
0.00047992728650569916,
-0.0055276695638895035,
0.004905295558273792,
0.026029473170638084,
-0.010602805763483047,
0.010356517508625984,
0.009352145716547966,
0.008489388972520828,
-0.004680238664150238,
0.007132531609386206,
0.07271727919578552,
-0.004765001125633717,
0.008944015949964523,
-0.02460477687418461,
0.014947203919291496,
0.005198454484343529,
0.0026545869186520576,
-0.0057240743190050125,
0.014238299801945686,
-0.02621176838874817,
0.012145017273724079,
-0.005511170253157616,
0.012533649802207947,
-0.015407596714794636,
0.010794896632432938,
-0.001096304040402174,
-0.0037476555444300175,
0.011000795289874077,
0.005837921053171158,
-0.018697921186685562,
-0.003560860175639391,
0.004317720886319876,
-0.0016716518439352512,
0.021049633622169495,
-0.010077431797981262,
-0.0018187903333455324,
-0.009147120639681816,
-0.01063392125070095,
-0.0065427133813500404,
0.003197307698428631,
-0.018098726868629456,
0.03950466215610504,
-0.0056135812774300575,
-0.010688988491892815,
-0.004019170068204403,
0.02601020596921444,
-0.015781879425048828,
0.003507736138999462,
-0.0007800546009093523,
-0.006749182939529419,
0.019847042858600616,
-0.017970405519008636,
0.005452902056276798,
0.015784375369548798,
-0.001059006666764617,
-0.008999213576316833,
0.009835041128098965,
-0.0006422414444386959,
-0.008468103595077991,
0.024829983711242676,
-0.005575200542807579,
-0.003350033424794674,
0.008184792473912239,
0.003355490043759346,
0.005242097191512585,
-0.011656159535050392,
-0.01662169210612774,
0.0015767274890094995,
0.021267754957079887,
-0.0010544294491410255,
-0.01525026373565197,
-0.008989048190414906,
-0.002738424576818943,
-0.003212080802768469,
0.0058095408603549,
-0.002177548361942172,
-0.006685396656394005,
0.0038255644030869007,
-0.005521334707736969,
-0.00026817829348146915,
0.002938853809610009,
-0.0021324530243873596,
-0.010886340402066708,
0.008689172565937042,
-0.05314302444458008,
0.00609701219946146,
-0.009609613567590714,
0.014270113781094551,
0.019373606890439987,
0.0005879462696611881,
-0.004671319387853146,
-0.02432437241077423,
0.021039556711912155,
0.005848931148648262,
-0.00647842139005661,
0.0046540782786905766,
-0.010261107236146927,
-0.07506410032510757,
-0.03656521439552307,
-0.010299872606992722,
-0.006701230071485043,
-0.0005723831709474325,
-0.008005120791494846,
-0.01655218005180359,
-0.014419592916965485,
-0.016926661133766174,
-0.010601802729070187,
-0.01274140365421772,
-0.002573425881564617,
0.006590569391846657,
0.0010573584586381912,
0.013589219190180302,
-0.000035490142181515694,
-0.0012074625119566917,
-0.01785978674888611,
-0.02982816845178604,
0.014125016517937183,
0.010294746607542038,
0.008687954396009445,
-0.02771156281232834,
-0.006944699212908745,
0.013303383253514767,
-0.08148336410522461,
0.00026662135496735573,
-0.016683349385857582,
-0.012492375448346138,
0.00751879159361124,
-0.02561619132757187,
0.002653087954968214,
-0.004395514726638794,
0.0021944029722362757,
-0.014904038049280643,
-0.012122586369514465,
0.023470792919397354,
0.00672137038782239,
-0.01835721731185913,
0.007620177231729031,
-0.005366848316043615,
0.003150120610371232,
0.008004777133464813,
-0.0005620750598609447,
0.005376428831368685,
0.004879574757069349,
-0.001988331787288189,
-0.005833344999700785,
0.013063713908195496,
-0.012054739519953728,
0.006179292686283588,
-0.007350672967731953,
0.0030635432340204716,
0.007848325185477734,
-0.005432577803730965,
0.008723940700292587,
0.031608421355485916,
0.00047317612916231155,
-0.028333507478237152,
0.019913293421268463,
-0.01309945248067379,
-0.0038595409132540226,
-0.0033955120015889406,
0.02679007686674595,
0.0083522479981184,
-0.007389991544187069,
-0.004033371806144714,
-0.00605284608900547,
-0.008902393281459808,
0.021362483501434326,
-0.002405572449788451,
0.00931202620267868,
-0.0013408802915364504,
0.021365491673350334,
-0.0019287457689642906,
-0.00011475011706352234,
-0.013933118432760239,
0.003606362733989954,
-0.013299714773893356,
-0.005023063160479069,
-0.020234230905771255,
-0.005647909361869097,
-0.003905773628503084,
-0.0034459871239960194,
0.0013392737600952387,
-0.0009716391796246171,
-0.0019318575505167246,
0.002544673625379801,
0.07177739590406418,
0.0025453134439885616,
-0.002455997746437788,
0.004699057899415493,
0.0014993620570749044,
0.00026874180184677243,
-0.027478327974677086,
-0.013616234064102173,
-0.016196412965655327,
-0.0014393950114026666,
-0.020942313596606255,
-0.0011327859247103333,
-0.012506971135735512,
0.008988447487354279,
0.0010242157150059938,
0.009159822016954422,
0.0006021070294082165,
0.011993316002190113,
0.007595228496938944,
0.007904238998889923,
0.0031576454639434814,
-0.008742972277104855,
-0.023563342168927193,
-0.004915913566946983,
0.04407384246587753,
-0.0004887876566499472,
0.013318812474608421,
-0.006097128614783287,
-0.01185429748147726,
0.002157470677047968,
-0.010726789012551308,
0.011862078681588173,
0.006640120409429073,
-0.0005976120010018349,
0.008460436016321182,
0.009460145607590675,
-0.001341425348073244,
0.004170016851276159,
-0.01586371287703514,
0.005547277629375458,
-0.006762971170246601,
-0.011459999717772007,
0.010785186663269997,
-0.04043980687856674,
0.002169819548726082,
-0.025473155081272125,
0.0008469668682664633,
0.001914097578264773,
-0.0044776517897844315,
0.018132179975509644,
-0.0025783113669604063,
0.005040972493588924,
0.014071528799831867,
0.010757584124803543,
-0.014039047993719578,
0.004817249719053507,
-0.02503836154937744,
0.012974174693226814,
0.030310755595564842,
0.005099683068692684,
-0.013604484498500824,
-0.0200770553201437,
0.014930123463273048,
-0.01780097931623459,
0.007784221321344376,
-0.026465382426977158,
0.015592335723340511,
-0.00976988673210144,
-0.0354623943567276,
0.010194480419158936,
0.011407386511564255,
0.004981552250683308,
-0.00015838941908441484,
-0.003518851939588785,
0.00560712581500411,
-0.0027597451116889715,
0.03664213418960571,
0.0039260657504200935,
-0.001271943561732769,
0.005586909595876932,
-0.006233568303287029,
-0.004218801856040955,
0.020313631743192673,
-0.010026400908827782,
-0.01480145938694477,
-0.015009826980531216,
-0.000086931511759758,
0.0006550755351781845,
-0.00895870104432106,
0.001071831677109003,
-0.009198402054607868,
0.014082008972764015,
0.003972786478698254,
0.001195572316646576,
0.0077345059253275394,
0.034074146300554276,
-0.007810411974787712,
0.0031138230115175247,
-0.025762081146240234,
-0.014394273981451988,
-0.008812363259494305,
-0.002607177011668682,
0.0017077191732823849,
0.01945393532514572,
-0.014163276180624962,
-0.005130560602992773,
0.005829280707985163,
0.004049322567880154,
0.016691485419869423,
-0.02178904414176941,
-0.006543376948684454,
0.0030424916185438633,
0.0049394164234399796,
0.012648804113268852,
0.013289375230669975,
-0.008650897070765495,
-0.010446490719914436,
-0.018180878832936287,
0.02387619949877262,
-0.01420506276190281,
-0.006189550738781691,
0.0013480519410222769,
-0.004075532779097557,
0.023274477571249008,
0.004375907592475414,
0.003902909578755498,
-0.000388662563636899,
0.005856749601662159,
0.010766521096229553,
0.003634227439761162,
0.006732541602104902,
0.00006203167140483856,
-0.013736083172261715,
0.006503195036202669,
0.011890428140759468,
0.019768014550209045,
0.005016786977648735,
0.002045154571533203,
-0.005773824639618397,
-0.023008814081549644,
0.02346993423998356,
-0.014614161103963852,
0.004631164483726025,
0.005508414935320616,
0.009462464600801468,
0.00020276452414691448,
0.028749532997608185,
-0.007454870734363794,
0.02876276522874832,
0.018933726474642754,
-0.012093201279640198,
0.005645496770739555,
0.01104041188955307,
-0.0015825617592781782,
-0.019832469522953033,
0.0038566282019019127,
0.009602943435311317,
-0.0038612564094364643,
-0.020754195749759674,
-0.007594047114253044,
-0.02437165379524231,
0.014700178056955338,
0.0060520898550748825,
-0.005940318573266268,
-0.005426282063126564,
0.0021122414618730545,
-0.015073126181960106,
0.0020010522566735744,
0.002890766365453601,
0.03360719606280327,
0.021443761885166168,
-0.006906956434249878,
-0.0005829376168549061,
0.006766885053366423,
-0.023147206753492355,
0.002723014447838068,
0.004294896498322487,
0.0041836160235106945,
-0.018198320642113686,
0.01905861683189869,
-0.008099116384983063,
0.03301258385181427,
-0.009000609628856182,
-0.008395482785999775,
-0.009941917844116688,
0.013245206326246262,
-0.010584468021988869,
0.014589477330446243,
0.016737325116991997,
-0.005366193130612373,
-0.008054985664784908,
-0.0034243627451360226,
-0.0039757187478244305,
-0.00520502682775259,
0.021552864462137222,
0.0019969220738857985,
-0.005327367223799229,
-0.0077762422151863575,
-0.018308836966753006,
-0.006034478545188904,
0.005149940960109234,
-0.01077649649232626
] | [
0.6692855954170227,
0.21227389574050903,
-0.4940805733203888,
-0.05925346538424492,
0.1889021098613739,
0.7673832774162292,
0.33795276284217834,
0.05295911431312561,
-0.20162168145179749,
-0.2608341872692108,
0.1280408799648285,
0.42958879470825195,
0.355703741312027,
-0.12323729693889618,
-0.010255112312734127,
0.6465714573860168,
0.6896809339523315,
-0.18405123054981232,
-0.051885783672332764,
-0.26687654852867126,
-0.33923226594924927,
-0.05483338609337807,
0.17600750923156738,
0.21445204317569733,
0.07976796478033066,
0.1535162627696991,
0.5234688520431519,
0.09824396669864655,
0.4539501667022705,
-0.22583703696727753,
0.2076830118894577,
0.07489988952875137,
0.19681353867053986,
-0.2291697859764099,
0.2229483276605606,
-0.1660187840461731,
-0.06262346357107162,
0.35276347398757935,
0.37698137760162354,
-0.04428833723068237,
-0.16112785041332245,
-0.01932305283844471,
-0.0423700213432312,
0.4387127757072449,
-0.20071366429328918,
-0.7510406970977783,
-0.8249018788337708,
0.559686005115509,
-0.22261753678321838,
0.285045862197876,
-0.07351087033748627,
0.19053766131401062,
0.7326739430427551,
-0.1603618711233139,
-0.04883792623877525,
0.3550865650177002,
-0.09675677120685577,
0.1670854389667511,
0.15573543310165405,
-0.529352068901062,
-0.06072882190346718,
0.12235621362924576,
-0.2802221179008484,
-0.03915957733988762,
-0.6009473204612732,
0.5303677916526794,
0.09790436178445816,
0.14754697680473328,
0.053212206810712814,
-0.43357664346694946,
0.07520923763513565,
-0.03351045772433281,
-0.4653737545013428,
0.1021895557641983,
-0.2958466708660126,
-0.45606282353401184,
0.14210167527198792,
-0.0035489213187247515,
0.25585564970970154,
-0.4075823724269867,
0.06753725558519363,
-0.397338330745697,
0.22299399971961975,
-0.7269038558006287,
0.8618330955505371,
0.27174118161201477,
0.21130132675170898,
0.11226966232061386,
-0.22175626456737518,
-0.441659539937973,
-0.4701410233974457,
-0.38025662302970886,
0.04275773465633392,
0.7824179530143738,
-0.10342960804700851,
0.37120622396469116,
0.3357638716697693,
0.15296801924705505,
0.4258093237876892,
0.12261679768562317,
-0.38715043663978577,
0.024092869833111763,
0.25176990032196045,
0.3954084515571594,
-0.39080628752708435,
-0.03191201388835907,
0.18682391941547394,
-0.19394755363464355,
-1.0433763265609741,
-0.032755691558122635,
-0.8299975395202637,
-0.27849939465522766,
-0.3574037253856659,
-0.4094451069831848,
-0.20226576924324036,
0.047090400010347366,
-0.0005537932156585157,
-0.4458746016025543,
-0.49593958258628845,
-0.142246812582016,
-0.6972746849060059,
0.49871009588241577,
-0.2856181263923645,
0.7862618565559387,
-0.16337931156158447,
0.3715754747390747,
0.36738619208335876,
0.02770230919122696,
-0.1660303771495819,
0.4727739989757538,
0.4545626938343048,
0.21471665799617767,
-0.2915861904621124,
0.13451384007930756,
-0.05222080647945404,
-0.15277288854122162,
0.20148150622844696,
0.6231294870376587,
-0.10838447511196136,
0.2022177278995514,
-0.4285791516304016,
-0.2942551076412201,
-0.011586853303015232,
0.3135083019733429,
0.2349584996700287,
-0.6913115978240967,
-0.07691068202257156,
0.09363198280334473,
-0.05180009827017784,
-0.5067585706710815,
-0.18297618627548218,
-0.0888947919011116,
-0.4999766945838928,
-0.21229012310504913,
0.26360011100769043,
0.7130535244941711,
-0.0009819387923926115,
-0.3075483739376068,
-0.2571547329425812,
0.09889586269855499,
0.5202769637107849,
0.5598951578140259,
-0.10011181235313416,
-0.22768330574035645,
0.5518571138381958,
-0.029406476765871048,
0.3466309607028961,
-0.15437380969524384,
0.007940354757010937,
0.60988450050354,
-0.7077236175537109,
0.08619242906570435,
-0.21182359755039215,
-0.8009157776832581,
-0.3482002317905426,
0.30329659581184387,
-0.08734171837568283,
0.04897407442331314,
0.012799442745745182,
0.14907822012901306,
-0.37733861804008484,
0.019043145701289177,
0.08868250995874405,
-0.5902999043464661,
-0.024564003571867943,
-0.564626932144165,
0.1460212618112564,
0.11473897844552994,
-0.030659237876534462,
0.15142260491847992,
-0.7212957143783569,
-0.3233449161052704,
0.7631250619888306,
-0.27411186695098877,
1.302675724029541,
-0.5691549181938171,
0.0865570604801178,
0.941470742225647,
0.36215442419052124,
-0.03246660530567169,
0.10506624728441238,
-0.011072508059442043,
0.16211843490600586,
0.07638153433799744,
-0.7975730895996094,
0.045222945511341095,
0.1522768884897232,
-0.33931764960289,
-0.08749537169933319,
-0.06123364716768265,
0.35221171379089355,
-0.1609942466020584,
-0.4630967378616333,
-0.4195401668548584,
0.12096333503723145,
0.27535516023635864,
-0.13661175966262817,
0.121827632188797,
0.32282379269599915,
-0.08345425873994827,
0.5004651546478271,
-0.48871955275535583,
0.6407901048660278,
0.28980010747909546,
0.20716255903244019,
0.40116173028945923,
0.47770267724990845,
0.1169472485780716,
0.5101889371871948,
-0.6629573702812195,
0.13911253213882446,
0.10672785341739655,
0.2890213429927826,
-0.6020235419273376,
-0.31314927339553833,
-0.14501315355300903,
-0.42264580726623535,
-0.008082432672381401,
0.018639009445905685,
-0.05080758407711983,
0.1567002832889557,
0.3239971101284027,
-0.7693480849266052,
-0.023843228816986084,
-0.22481957077980042,
-0.4353199601173401,
-0.5047867894172668,
0.11116529256105423,
-0.5594598650932312,
0.3757157325744629,
-0.17331171035766602,
0.15367096662521362,
-0.13155749440193176,
-0.06784479320049286,
-0.3361833989620209,
0.12515956163406372,
0.09113297611474991,
-0.8281788229942322,
0.2743963897228241,
-0.7656073570251465,
-0.038260914385318756,
0.1850084662437439,
0.2465069442987442,
0.2839291989803314,
0.3847680389881134,
-0.5035467743873596,
-0.5328624844551086,
-0.7687653303146362,
0.9114101529121399,
0.5585784912109375,
0.5594192743301392,
0.10050123929977417,
-0.3705104887485504,
0.04019340127706528,
-0.3038089871406555,
-0.7731534838676453,
0.40983647108078003,
0.5788251757621765,
-0.4281291365623474,
-0.6102901101112366,
0.055163584649562836,
0.03225521743297577,
0.5394919514656067,
-0.5782644152641296,
0.04635513946413994,
-0.3058892786502838,
-0.3076471984386444,
0.05431695282459259,
-0.5924510955810547,
0.014091617427766323,
-0.3228728473186493,
0.3165445029735565,
0.11165186762809753,
-0.5350523591041565,
0.38217318058013916,
0.27980542182922363,
-0.07771938294172287,
0.12254835665225983,
0.5277068614959717,
-0.214832603931427,
0.23867419362068176,
0.4393409490585327,
-0.03736695647239685,
0.03111506812274456,
-0.23915158212184906,
-0.10400552302598953,
-0.32332026958465576,
0.10292621701955795,
-6.084433078765869,
0.22970061004161835,
-0.3838440775871277,
-0.1841709017753601,
0.026995563879609108,
-0.06160694733262062,
1.047008752822876,
-0.09480362385511398,
0.4059349596500397,
-0.5441802144050598,
-0.13754865527153015,
0.6628292798995972,
-0.22943510115146637,
0.2364768534898758,
0.08724649250507355,
0.3841359317302704,
0.465239018201828,
-0.12529189884662628,
0.6783271431922913,
0.6273384690284729,
0.08931123465299606,
-0.32031670212745667,
-0.1551346480846405,
0.143351212143898,
0.2678373157978058,
0.4951309859752655,
-1.2094600200653076,
0.2749860882759094,
-0.06738097965717316,
0.10920628160238266,
0.30013197660446167,
-0.757193386554718,
0.03281628340482712,
-0.13373428583145142,
0.2876282334327698,
0.1977078765630722,
0.40462350845336914,
0.016741694882512093,
0.055825501680374146,
-0.0451127290725708,
-0.1484050452709198,
0.3167095184326172,
-0.22979088127613068,
-0.22943097352981567,
0.3547418415546417,
0.17724846303462982,
0.09874337166547775,
0.07664205133914948,
-0.0912444218993187,
0.9060236811637878,
-0.0063387202098965645,
0.0016707860631868243,
-0.054774072021245956,
0.707328200340271,
0.10189049690961838,
-0.40939387679100037,
-0.053739506751298904,
0.5346336960792542,
0.10212092101573944,
0.34226781129837036,
0.0076870121993124485,
-0.2651626169681549,
0.3878765404224396,
-0.9012547731399536,
-0.05438082665205002,
0.08163364976644516,
-0.39807549118995667,
-0.2391446977853775,
-0.44661933183670044,
-0.1169872060418129,
-0.22032319009304047,
-0.12886454164981842,
-0.06522873789072037,
-0.5404335856437683,
-0.2661995589733124,
-0.5436928868293762,
-0.08149603009223938,
-0.05787298455834389,
0.13066288828849792,
-0.3657442629337311,
-0.16509905457496643,
-0.04860619455575943,
0.4862436354160309,
-0.21688689291477203,
-0.002743832767009735,
0.06375439465045929,
-0.138492614030838,
-0.054574210196733475,
-0.0020347696263343096,
0.2702077329158783,
0.5094290971755981,
-0.32814720273017883,
0.09867095947265625,
0.2505454123020172,
0.7683717608451843,
0.9286616444587708,
0.32273897528648376,
-0.02898208424448967,
0.36041194200515747,
-0.5053780674934387,
0.48264312744140625,
-0.5062092542648315,
-0.46247828006744385,
-0.8409897685050964,
-0.26341086626052856,
-0.14881184697151184,
-0.7301275134086609,
0.07791820168495178,
0.6010579466819763,
-0.6341840028762817,
0.26113227009773254,
-0.023796549066901207,
-0.22070465981960297,
0.12258350104093552,
0.49696749448776245,
-0.2751159071922302,
-0.15048882365226746,
-0.05068563297390938,
0.6316832900047302,
0.008743374608457088,
-0.1315913200378418,
0.10539577156305313,
-0.0841577798128128,
0.4795179069042206,
0.46601295471191406,
-0.4585958421230316,
0.22956141829490662,
0.07372541725635529,
-0.6455748677253723,
0.2748242914676666,
-0.22877517342567444,
0.5402997732162476,
-0.45042333006858826,
0.07266241312026978,
-0.0571623221039772,
-0.13552691042423248,
-0.17066606879234314,
-0.2375582605600357,
0.23155944049358368,
0.2771095037460327,
-0.039237797260284424,
0.2317105233669281,
-0.05205829069018364,
0.26193827390670776,
0.728912889957428,
-0.05723004788160324,
-0.45967087149620056,
0.01199983712285757,
-0.1021910011768341,
0.08768901228904724,
0.19726242125034332,
0.3926141858100891,
0.013146444223821163,
-0.09735080599784851,
-0.5348020792007446,
0.20083396136760712,
0.1489388793706894,
0.1257724165916443,
-0.10380604863166809,
0.34945788979530334,
0.6993943452835083,
-0.10240451246500015,
-1.0830713510513306,
-0.04610823839902878,
0.26579102873802185,
-0.5397251844406128,
0.008903258480131626,
-0.47784221172332764,
-0.18631905317306519,
-0.03840078040957451,
0.13098065555095673,
-0.4651021957397461,
-0.1783623844385147,
-0.2808207869529724,
0.14500831067562103,
-0.43618297576904297,
-0.3623984754085541,
0.4716736972332001,
-0.32908493280410767,
0.3296811282634735,
0.13265460729599,
-0.27024292945861816,
-0.2930527925491333,
0.3613075017929077,
1.0118305683135986,
0.57335364818573,
-0.5259356498718262,
-0.6830708384513855,
-0.18760353326797485,
-0.13067887723445892,
0.23254163563251495,
-0.1440398395061493,
0.6966750025749207,
0.15715639293193817,
-0.009408188983798027,
-0.4942456781864166,
0.07209990918636322,
0.636799156665802,
-0.034029457718133926,
-0.1128564178943634,
-0.05383540317416191,
0.5022792816162109,
-0.43787404894828796,
0.5023756623268127,
0.5282090902328491,
-0.1543239951133728,
0.2804059386253357,
-0.5205653309822083,
-0.11340313404798508,
-0.4939733147621155,
-0.21451899409294128,
-0.1773861050605774,
-0.43780574202537537,
0.5486090779304504,
-0.6957584023475647,
0.26007527112960815,
0.09558779746294022,
-0.3957158327102661,
-0.2226024717092514,
0.37220877408981323,
0.11069261282682419,
-0.061092350631952286,
-0.49698758125305176,
-0.11332970857620239,
-0.18150639533996582,
0.21250221133232117,
0.6265390515327454,
-0.7863184809684753,
-0.457035630941391,
0.3870336413383484,
-0.5045386552810669,
-0.09793129563331604,
0.12555333971977234,
0.140040785074234,
-0.635016918182373,
0.26901766657829285,
0.02561899833381176,
-0.1439778059720993,
0.08252034336328506,
0.2545809745788574,
-0.10288653522729874,
0.4453893303871155,
0.1099596843123436,
-0.38517698645591736,
-0.060353223234415054,
0.12782494723796844,
0.3318685293197632,
-0.18560916185379028,
-0.22108212113380432,
0.03144540265202522,
0.29583945870399475,
-0.2830778658390045,
-0.0401853509247303,
-0.418397456407547,
-0.11344394832849503,
0.4051083028316498,
-0.42760610580444336,
-0.5559899210929871,
-0.07092734426259995,
0.07386620342731476,
0.16487273573875427,
-0.7307780981063843,
0.026919838041067123,
-0.3941943049430847,
-0.035287775099277496,
-0.4900414049625397,
-0.3610260486602783,
-0.6063520312309265,
0.24757462739944458,
-0.40245088934898376,
0.06407562643289566,
-0.18042072653770447,
0.4136839807033539,
0.1856999546289444,
0.3138387203216553,
0.14607052505016327,
-0.4088296592235565,
0.1414821892976761,
0.07523898035287857,
0.30559343099594116,
-0.2024221122264862,
-0.30626431107521057,
0.008910218253731728,
-0.0980318933725357,
0.33692097663879395,
-0.3443605899810791,
0.41007763147354126,
0.031877726316452026,
-0.26225554943084717,
-0.4350787401199341,
-0.06957380473613739,
-0.2730114459991455,
-0.34009459614753723,
0.06702621281147003,
0.1059359535574913,
0.29011040925979614,
0.6907145977020264,
0.18380481004714966,
0.3127395510673523,
-0.2608596980571747,
-0.12156166136264801,
0.8207996487617493,
0.2938911020755768,
-0.4353187680244446,
0.5028555393218994,
-0.16762858629226685,
-0.05540560930967331,
-0.04831512272357941,
0.03665321320295334,
0.09592902660369873,
0.46315693855285645,
-0.038088418543338776,
0.3187059164047241,
0.4741086959838867,
-0.4206647574901581,
-0.008131984621286392,
-0.18465347588062286,
-0.47281593084335327,
0.6382845640182495,
0.03848950192332268,
-0.22917097806930542,
0.6665668487548828,
0.7376229763031006,
-0.10806639492511749,
0.25919756293296814,
0.6366994380950928,
-0.10073252767324448,
0.22577492892742157,
0.1984928995370865,
0.41506415605545044,
0.11462618410587311,
0.8251605033874512,
0.042604994028806686,
0.14298957586288452,
0.12572146952152252,
0.4917643964290619,
0.42846548557281494,
-0.4903852045536041,
0.01345507986843586,
0.18692226707935333,
0.765403687953949,
0.1846582144498825,
0.29826366901397705,
-0.07600931078195572,
0.0792282447218895,
0.23524215817451477,
0.04610816016793251,
0.38083615899086,
0.041541360318660736,
0.6176407933235168,
0.02133750729262829,
-0.29243505001068115,
-0.09320518374443054,
0.27724018692970276,
-0.12951305508613586,
0.06510741263628006,
-0.09846252202987671,
0.14775575697422028,
-0.7838892936706543,
0.23069292306900024,
0.2602432370185852,
-0.0012962473556399345,
0.04073254391551018,
0.1418488621711731,
-0.27100685238838196,
0.052462752908468246,
0.2285534143447876,
0.09864441305398941,
0.04116411879658699,
0.0005564868915826082,
-0.07663746178150177,
0.09161341935396194,
0.02810700424015522,
0.29069042205810547,
0.17244186997413635,
-0.7306926846504211,
0.07736638188362122,
0.015704356133937836,
-0.13627159595489502,
0.37749797105789185,
-0.22803691029548645,
-0.5764040350914001,
-0.1719917207956314,
0.33384066820144653,
0.12094558775424957,
0.00013872735144104809,
-0.4121200144290924,
0.24217183887958527,
-0.2736504077911377,
0.11878582090139389,
0.038905199617147446,
-0.7369685769081116,
0.10706812888383865,
0.18753781914710999,
-0.18113070726394653,
0.09958165884017944,
-0.14835752546787262,
0.3356354832649231,
0.2694789171218872,
0.05756417289376259,
-0.10593777894973755,
-0.14019161462783813,
-0.12577109038829803,
0.5248995423316956,
-0.21260657906532288,
0.18219085037708282,
-0.4737768769264221,
-0.1583438664674759,
-0.9333797693252563,
-0.23200032114982605,
0.5735151767730713,
0.07992222905158997,
-0.09365510940551758,
0.15555411577224731,
-0.1222633570432663,
0.740368664264679,
0.41339820623397827,
-0.08312554657459259,
-0.1816965490579605,
-0.3496340811252594,
-0.43064385652542114,
-0.8655179142951965,
0.034694645553827286,
0.027458110824227333,
-0.2686907947063446,
-0.3607867658138275,
0.2599380910396576,
0.7094115018844604,
-0.35663658380508423,
0.5731202363967896,
-0.05400377884507179,
-0.44800734519958496,
-0.43964308500289917,
0.5358381867408752,
-0.6833295226097107,
0.3197588622570038,
0.601750373840332,
0.6068633198738098,
0.0153233353048563,
-0.3947778344154358,
0.19682767987251282,
-0.5162709951400757,
0.31391605734825134,
0.28392401337623596,
-0.2854156196117401,
0.3787226676940918,
-0.13347302377223969,
0.02296791411936283,
-0.6710650324821472,
0.1527290940284729,
-0.19054879248142242,
-0.7098736763000488,
-0.007884595543146133,
-0.3094647228717804,
-0.5346372723579407,
-0.11092891544103622,
-0.11322322487831116,
-0.5050917267799377,
-0.13006950914859772,
-0.23824359476566315
] |
Acute lung injury (ALI) that clinically manifests as acute respiratory distress syndrome is caused by an uncontrolled systemic inflammatory response resulting from clinical events including sepsis, major surgery and trauma. Innate immunity activation plays a central role in the development of ALI. Innate immunity is activated through families of related pattern recognition receptors (PRRs), which recognize conserved microbial motifs or pathogen-associated molecular patterns (PAMPs). Toll-like receptors were the first major family of PRRs discovered in mammals. Recently, NACHT–leucine-rich repeat (LRR) receptors and retinoic acid–inducible gene–like receptors have been added to the list. It is now understood that in addition to recognizing infectious stimuli, both Toll-like receptors and NACHT-LRR receptors can also respond to endogenous molecules released in response to stress, trauma and cell damage. These molecules have been termed damage-associated molecular patterns (DAMPs). It has been clinically observed for a long time that infectious and noninfectious insults initiate inflammation, so confirmation of overlapping receptor-signal pathways of activation between PAMPs and DAMPs is no surprise. This review provides an overview of the PRR-dependent mechanisms of ALI and clinical implication. Modification of PRR pathways is likely to be a logical therapeutic target for ALI/acute respiratory distress syndrome. | [
-0.007186073809862137,
-0.0030616724397987127,
-0.012390706688165665,
0.011685105971992016,
0.001385371433570981,
0.013159339316189289,
0.00941475573927164,
0.014061104506254196,
-0.01076621375977993,
0.0036861489061266184,
-0.009766568429768085,
0.004637420177459717,
-0.01710745319724083,
0.023369500413537025,
0.0005613118410110474,
0.01321612298488617,
0.003479486331343651,
0.023020347580313683,
0.0111342528834939,
0.01752001978456974,
0.012209711596369743,
0.006386040709912777,
0.010805289261043072,
-0.015157833695411682,
-0.007538442965596914,
0.003957425244152546,
0.011432298459112644,
-0.004394385032355785,
-0.040486909449100494,
-0.012724359519779682,
-0.001115159597247839,
0.016394419595599174,
-0.0003147488459944725,
0.01327434740960598,
-0.00663380092009902,
-0.039191216230392456,
-0.007969622500240803,
0.006665281020104885,
0.03927332162857056,
-0.005041065625846386,
0.007779048290103674,
-0.015132828615605831,
0.003176072146743536,
-0.01999744586646557,
-0.0071875713765621185,
-0.024218566715717316,
0.001673451391980052,
-0.0008125799940899014,
-0.021061066538095474,
0.010436076670885086,
0.0006478040013462305,
-0.01121225580573082,
-0.012945524416863918,
-0.002590361051261425,
-0.006765696220099926,
0.010790621861815453,
0.02000764012336731,
0.0018167677335441113,
0.007280396297574043,
-0.02224959060549736,
0.014375909231603146,
-0.009945923462510109,
-0.015140416100621223,
-0.03792131692171097,
0.006365709938108921,
-0.06679851561784744,
0.0193011574447155,
-0.008421316742897034,
-0.007249938324093819,
0.0034849278163164854,
0.01492320280522108,
0.01043577492237091,
-0.03311267867684364,
-0.0026670340448617935,
-0.004240039736032486,
-0.007560146972537041,
-0.0024742966052144766,
0.018585680052638054,
0.02126755192875862,
0.02862420491874218,
-0.01729145646095276,
0.0022788336500525475,
0.0060333432629704475,
0.008887752890586853,
-0.020599806681275368,
0.027932144701480865,
-0.022223034873604774,
0.00991588830947876,
0.00127492006868124,
0.005539753939956427,
0.011250028386712074,
0.0232943557202816,
-0.03652019426226616,
0.0015806667506694794,
-0.00728883221745491,
0.006108558736741543,
-0.023043997585773468,
0.02186395972967148,
0.023566395044326782,
0.025067724287509918,
-0.019857700914144516,
-0.013055860064923763,
0.017961053177714348,
0.0016930364072322845,
0.01534240785986185,
0.005814934149384499,
-0.022670751437544823,
0.004843598697334528,
0.011467509903013706,
0.012856539338827133,
-0.01420909445732832,
0.031212609261274338,
-0.004681999795138836,
0.012503942474722862,
0.007096774876117706,
0.01708938553929329,
0.004433995578438044,
0.007013258524239063,
0.01936512067914009,
-0.012378786690533161,
0.03966030478477478,
0.008417394012212753,
0.0037458213046193123,
0.01773923821747303,
-0.0014844832476228476,
0.017155522480607033,
0.0065201460383832455,
0.0054657175205647945,
-0.005606546998023987,
0.015264227986335754,
-0.007126996293663979,
0.015113943256437778,
-0.012195073999464512,
-0.011997911147773266,
0.0023030084557831287,
0.006224189884960651,
-0.01316737849265337,
-0.012324272654950619,
-0.00569179467856884,
-0.018593357875943184,
-0.01017842162400484,
0.01587163843214512,
-0.0024566990323364735,
0.01990521140396595,
0.013676486909389496,
0.005608835257589817,
0.04672901704907417,
0.006024891510605812,
0.008328411728143692,
-0.0023480274248868227,
0.010202830657362938,
-0.0018242360092699528,
0.014346362091600895,
-0.026453819125890732,
0.026396997272968292,
0.04260930418968201,
-0.023473592475056648,
-0.021366911008954048,
-0.002314439043402672,
0.012078678235411644,
0.025062518194317818,
-0.02103254571557045,
0.006742438301444054,
0.008343523368239403,
0.025429679080843925,
-0.002699990523979068,
0.02256809175014496,
-0.01786392368376255,
-0.012816899456083775,
0.012215414084494114,
-0.0032832284923642874,
0.012092569842934608,
-0.0018070535734295845,
0.012691589072346687,
0.003420521505177021,
-0.010671151801943779,
0.01629246398806572,
0.008841915987432003,
-0.017013609409332275,
0.06658884137868881,
0.0302562452852726,
-0.021653475239872932,
0.02863052859902382,
0.006544949486851692,
0.02545134350657463,
0.016490455716848373,
0.05832620710134506,
-0.002596326870843768,
-0.0172423105686903,
0.027733661234378815,
-0.010440840385854244,
0.0030829962342977524,
-0.004819110967218876,
0.004384348634630442,
-0.03350261226296425,
0.0021903240121901035,
0.019890645518898964,
0.012819025665521622,
-0.01794704794883728,
0.015314476564526558,
0.028452321887016296,
-0.021914847195148468,
0.044946782290935516,
-0.014073522761464119,
-0.017916426062583923,
0.009811006486415863,
-0.01850946992635727,
-0.020518586039543152,
-0.04589366540312767,
0.00925780925899744,
0.0198558010160923,
-0.03135104477405548,
-0.01146625354886055,
-0.006796891801059246,
0.0035552745684981346,
-0.0021352001931518316,
-0.0019408664666116238,
-0.010846341960132122,
-0.007062271237373352,
-0.011986986733973026,
0.002239181427285075,
0.03359546884894371,
0.0004415074363350868,
-0.019801581278443336,
0.02192370966076851,
-0.0008691886905580759,
0.0015134005807340145,
0.013056677766144276,
-0.0019734855741262436,
0.005990134552121162,
-0.010189657099545002,
-0.028246412053704262,
-0.014381129294633865,
-0.036486703902482986,
0.030318699777126312,
0.0026748129166662693,
0.016056573018431664,
-0.016123637557029724,
0.021082861348986626,
-0.012954134494066238,
-0.019715458154678345,
-0.0013145571574568748,
0.01517508178949356,
-0.00886431336402893,
0.028207115828990936,
-0.015413369983434677,
-0.009764684364199638,
-0.01623005047440529,
0.03224242851138115,
-0.023490794003009796,
0.011551032774150372,
-0.005967443808913231,
0.003272661007940769,
0.007725705858319998,
0.02891993522644043,
-0.001317403744906187,
-0.007661939598619938,
-0.016773194074630737,
0.022993341088294983,
0.023446686565876007,
0.00706927664577961,
0.00919843465089798,
-0.01959262602031231,
-0.015312744304537773,
-0.016506381332874298,
0.04549790918827057,
-0.020180940628051758,
-0.002019955776631832,
-0.014137792401015759,
-0.031093984842300415,
0.009672718122601509,
-0.009635798633098602,
-0.005298033356666565,
-0.08052700757980347,
-0.011459730565547943,
-0.02257145754992962,
-0.021225569769740105,
0.008355319499969482,
-0.008402667939662933,
0.01602623239159584,
0.012408647686243057,
-0.002989370608702302,
0.038635529577732086,
0.011262383311986923,
-0.01998916268348694,
-0.012482522055506706,
0.03514235466718674,
-0.007342067547142506,
-0.0035787972155958414,
0.00204800209030509,
0.007551523391157389,
-0.01798686385154724,
-0.020843934267759323,
0.013254684396088123,
-0.005667882040143013,
0.01661747880280018,
0.00293146213516593,
0.00397958979010582,
0.015327327884733677,
0.007216605823487043,
-0.015535455197095871,
0.018162058666348457,
0.007411832455545664,
-0.013819588348269463,
-0.009689941070973873,
-0.001506639295257628,
-0.005552192218601704,
0.020583992823958397,
0.004709568340331316,
-0.0026592244394123554,
-0.033099524676799774,
-0.010390845127403736,
0.006909795105457306,
0.002807255368679762,
0.014068672433495522,
0.010613725520670414,
0.013691899366676807,
0.0077920169569551945,
0.01276538148522377,
0.005935676395893097,
0.035591959953308105,
0.020143479108810425,
-0.015551265329122543,
-0.0013929903507232666,
0.00004562045796774328,
-0.008845296688377857,
0.022971514612436295,
-0.012060596607625484,
-0.02226075530052185,
0.0006584795191884041,
-0.009121377021074295,
-0.007056961301714182,
-0.00526323402300477,
-0.029955238103866577,
-0.005453511141240597,
0.0399228073656559,
0.005789186339825392,
-0.013163205236196518,
-0.009709184058010578,
0.005329949781298637,
0.0036243004724383354,
-0.008372912183403969,
0.01986848935484886,
0.007543351501226425,
0.02703654207289219,
-0.03585216403007507,
-0.015711165964603424,
0.0014084149152040482,
-0.007335413247346878,
-0.00931532308459282,
-0.002245510695502162,
-0.022754177451133728,
0.009371578693389893,
-0.026066076010465622,
0.007076877169311047,
0.0009022234007716179,
0.008391161449253559,
-0.014423131942749023,
-0.01796513795852661,
0.01107792928814888,
0.02388608083128929,
0.015799393877387047,
-0.017294099554419518,
0.054885320365428925,
0.04229705035686493,
0.013925429433584213,
0.012740682810544968,
-0.0005204260814934969,
-0.009696733206510544,
-0.039902277290821075,
-0.01526218093931675,
-0.010993048548698425,
0.009556571021676064,
-0.047846660017967224,
-0.013791084289550781,
-0.024989929050207138,
-0.0064698318019509315,
-0.018838584423065186,
0.015153773128986359,
0.021930228918790817,
0.0039270236156880856,
-0.006793048232793808,
-0.005640603601932526,
0.0017459644004702568,
0.0006554804276674986,
-0.0011446785647422075,
0.023806098848581314,
0.010059189051389694,
0.01275466475635767,
0.0022123807575553656,
-0.007279899902641773,
0.07197389751672745,
-0.028047757223248482,
-0.010188382118940353,
-0.021097738295793533,
0.028559736907482147,
-0.008083305321633816,
-0.012686577625572681,
0.005312071181833744,
0.009057598188519478,
0.011123422533273697,
0.011521618813276291,
-0.012789115309715271,
-0.04874134063720703,
-0.02217985689640045,
-0.0365578830242157,
-0.0014653922989964485,
0.015968406572937965,
0.007943992502987385,
0.025294650346040726,
0.026347529143095016,
-0.013914329931139946,
-0.02314724400639534,
0.0009137222077697515,
0.00780833326280117,
-0.008702383376657963,
-0.0004236262757331133,
0.04573633894324303,
-0.01483156904578209,
-0.017140069976449013,
0.012930994853377342,
-0.01921500638127327,
-0.0008531407220289111,
-0.006760151591151953,
0.01811310090124607,
-0.02465720847249031,
-0.010191637091338634,
0.03166051581501961,
-0.008023460395634174,
-0.0118060652166605,
0.005440928041934967,
-0.0021022739820182323,
-0.014904508367180824,
0.0006141243502497673,
0.015383162535727024,
-0.0009204056113958359,
0.02445795014500618,
-0.0043311407789587975,
-0.008089078590273857,
-0.019298065453767776,
0.002212667837738991,
-0.012211073189973831,
0.023126356303691864,
0.007521746680140495,
0.007172157987952232,
0.006541407201439142,
0.011835884302854538,
0.018760597333312035,
-0.007170756347477436,
0.002294391393661499,
-0.03245020657777786,
-0.008895715698599815,
-0.0465555302798748,
0.018405504524707794,
-0.003296850249171257,
0.014894464984536171,
-0.008169213309884071,
0.013400135561823845,
-0.005067468620836735,
-0.03084324300289154,
0.012431980110704899,
0.021038824692368507,
-0.007842760533094406,
-0.03376889228820801,
-0.018617158755660057,
-0.02869664877653122,
0.009229355491697788,
0.006049917545169592,
-0.001810215413570404,
0.03440644219517708,
-0.023136962205171585,
-0.027277886867523193,
0.02761704847216606,
0.05110960081219673,
-0.03607918694615364,
0.002558187348768115,
-0.01802109368145466,
-0.01371166855096817,
-0.07392631471157074,
-0.014229681342840195,
-0.0013174987398087978,
-0.010981987230479717,
0.010177175514400005,
0.0005309546831995249,
-0.007662174757570028,
0.020049694925546646,
-0.03142932429909706,
-0.008582646027207375,
0.012356756255030632,
-0.00854055117815733,
0.015535760670900345,
-0.000789975980296731,
0.015055174008011818,
0.026573404669761658,
0.008700336329638958,
0.005887972190976143,
-0.010427836328744888,
-0.01688012108206749,
0.009516697376966476,
0.019155798479914665,
-0.022486815229058266,
0.021012842655181885,
0.00274611241184175,
-0.0803554505109787,
-0.006137173622846603,
0.010129854083061218,
-0.006234155502170324,
-0.020282862707972527,
0.002482685260474682,
0.02268381603062153,
0.0031494884751737118,
-0.031078074127435684,
-0.016364499926567078,
0.010508731938898563,
0.0041881138458848,
0.005930835381150246,
-0.01541715394705534,
0.02867058292031288,
-0.008642001077532768,
0.02768717333674431,
-0.004311049357056618,
0.024126719683408737,
-0.025435902178287506,
-0.006321115419268608,
-0.012587705627083778,
-0.011837100610136986,
0.012420596554875374,
-0.008251681923866272,
-0.009951102547347546,
-0.003194387536495924,
0.020354628562927246,
-0.001561601646244526,
-0.03753369674086571,
0.01624952256679535,
-0.026983054354786873,
-0.025940272957086563,
0.006482008378952742,
0.011141976341605186,
-0.012554540298879147,
-0.003751827636733651,
0.011896764859557152,
0.00404637074097991,
-0.0076104337349534035,
-0.008261405862867832,
-0.008304554037749767,
-0.024832436814904213,
0.0072644902393221855,
-0.0032193062361329794,
-0.005131837911903858,
0.008207407779991627,
-0.005214165896177292,
0.009742257185280323,
0.0037149861454963684,
0.009579407051205635,
0.022554969415068626,
0.037258654832839966,
0.013842114247381687,
0.01894163154065609,
0.0008504125289618969,
-0.009200114756822586,
-0.007208049297332764,
-0.01480988971889019,
0.010761681944131851,
-0.006523604039102793,
-0.012671955861151218,
0.02636445313692093,
0.0716627687215805,
-0.001414276659488678,
0.025835758075118065,
-0.030726445838809013,
0.012789279222488403,
0.0017200493020936847,
0.0013433911371976137,
-0.01063468772917986,
-0.011608047410845757,
-0.0306144617497921,
0.014770791865885258,
-0.025452444329857826,
0.011725375428795815,
0.01364641822874546,
0.018367305397987366,
0.006252134218811989,
0.004746600054204464,
-0.02505447342991829,
0.003598795272409916,
0.005544994026422501,
-0.006498799659311771,
-0.014662832021713257,
-0.031798891723155975,
-0.000825849361717701,
0.018093090504407883,
0.0007232160423882306,
0.01833796501159668,
-0.012478930875658989,
-0.03326449915766716,
0.037859730422496796,
-0.012685773894190788,
0.0016572437016293406,
-0.002844459842890501,
-0.01047741249203682,
0.01613467186689377,
-0.014092016033828259,
0.025343606248497963,
0.008304659277200699,
-0.018196335062384605,
0.028789754956960678,
-0.004755458794534206,
-0.0032352986745536327,
0.00951949879527092,
-0.0007256902754306793,
0.015247005969285965,
0.015283173881471157,
0.030819451436400414,
-0.010976816527545452,
0.04973553866147995,
0.005544797517359257,
-0.021535424515604973,
0.003929507918655872,
0.025334620848298073,
0.0041001932695508,
0.0174400731921196,
0.02262880653142929,
0.006157428491860628,
0.011860540136694908,
-0.014001332223415375,
0.001837961026467383,
-0.006427638698369265,
-0.014224481768906116,
0.04760454595088959,
-0.021365754306316376,
0.019956540316343307,
0.010199573822319508,
-0.0068426611833274364,
-0.02292013168334961,
-0.021016918122768402,
0.014568510465323925,
-0.010560505092144012,
-0.005223593208938837,
0.011605345644056797,
0.0021490189246833324,
0.060733627527952194,
0.02114248275756836,
0.02301998808979988,
0.009617811068892479,
-0.008542455732822418,
0.0030844793654978275,
-0.01522914320230484,
-0.006650752387940884,
0.004765504039824009,
0.012643801979720592,
0.0005881045944988728,
0.006716120056807995,
0.000526385847479105,
-0.004348368383944035,
-0.000719066709280014,
0.014428961090743542,
0.0009878459386527538,
0.01132943108677864,
0.010413596406579018,
0.024563392624258995,
0.013268180191516876,
0.03337707370519638,
0.021381095051765442,
0.0076739895157516,
0.007341774180531502,
-0.004988012835383415,
-0.030789269134402275,
0.012587804347276688,
-0.005809162277728319,
0.020190449431538582,
0.006609020754694939,
-0.001676037791185081,
0.030183378607034683,
-0.006143532227724791,
-0.036361757665872574,
-0.021293552592396736,
0.016544150188565254,
0.021249573677778244,
0.009633434936404228,
-0.005602327175438404,
0.02066139131784439,
0.03236328810453415,
-0.009253527037799358,
-0.016371294856071472,
0.014355289749801159,
-0.01139160804450512,
0.0006219516508281231,
0.011084523983299732,
-0.0069315130822360516,
0.02074643038213253,
-0.01214686781167984,
-0.022387562319636345,
-0.008593916893005371,
-0.009390277788043022,
0.0009162472561001778,
0.009251490235328674,
0.028261709958314896,
-0.007865780033171177,
-0.016547175124287605,
-0.01677204668521881,
0.003218528814613819,
0.04282153397798538,
0.01151617243885994,
0.03035123646259308,
0.015583119355142117,
0.018507519736886024,
0.022879142314195633,
-0.02203403413295746,
-0.0028235591016709805,
-0.0018957466818392277,
0.008204912766814232,
-0.018475733697414398,
0.01669560745358467,
-0.00528676388785243,
0.010661812499165535,
0.01497750636190176,
0.000745801255106926,
-0.0012795531656593084,
0.0022631206084042788,
-0.015287354588508606,
0.04302648454904556,
0.016723863780498505,
0.003604345256462693,
0.002868472132831812,
-0.022831134498119354,
0.006780242547392845,
0.003347344696521759,
-0.0389578603208065,
0.014244952239096165,
-0.014737355522811413,
0.001701883040368557,
-0.025008240714669228,
0.0163943562656641,
0.016769779846072197,
0.004144923761487007,
-0.041316188871860504,
0.021174844354391098,
-0.008933679200708866,
-0.005653478670865297,
0.019564300775527954,
-0.037134312093257904,
-0.01448043156415224,
-0.014928259886801243,
0.0021590562537312508,
-0.02610461786389351,
0.010269936174154282,
0.008306273259222507,
-0.04250221699476242,
0.019890204071998596,
-0.014262789860367775,
-0.01387661974877119,
-0.01755342073738575,
-0.012972705066204071,
0.0020284357015043497,
-0.0010542874224483967,
0.024618525058031082,
-0.013784553855657578,
-0.026050379499793053,
-0.005673244595527649,
0.002875314559787512,
-0.0315798819065094,
-0.016174735501408577,
-0.008908056654036045,
-0.04911921173334122,
-0.0019360948354005814,
-0.0027151606045663357,
0.00048053660430014133,
-0.0014624051982536912
] | [
-0.3139038383960724,
0.1461314857006073,
0.04961903765797615,
-0.3909605145454407,
-0.12643179297447205,
0.021752716973423958,
0.3189219832420349,
-0.2135820835828781,
0.12202664464712143,
-0.6618365049362183,
0.02850383147597313,
0.5002853274345398,
-0.48327550292015076,
0.16618074476718903,
0.33775079250335693,
0.5877615809440613,
0.3066347539424896,
0.20316842198371887,
-0.718009889125824,
-0.2768488824367523,
0.032858334481716156,
-0.5778535604476929,
-0.02823113463819027,
0.22007375955581665,
0.903956413269043,
-0.07641108334064484,
0.28884342312812805,
-0.21479807794094086,
0.7429456114768982,
-0.21741434931755066,
0.33744895458221436,
0.5429996848106384,
-0.26036739349365234,
-0.4581741988658905,
-0.7288143634796143,
0.5069488883018494,
-0.6552255749702454,
-0.16946068406105042,
-0.16570013761520386,
-0.31469401717185974,
-0.32992616295814514,
-0.3264404833316803,
-0.2718331217765808,
0.6185287833213806,
-0.16188831627368927,
-0.5373941659927368,
-1.8301379680633545,
0.5128738880157471,
-0.06405068188905716,
0.29040321707725525,
0.18914659321308136,
0.0029483793769031763,
0.4620688259601593,
-0.09990589320659637,
0.3759164810180664,
-0.033700186759233475,
-0.5757281184196472,
-0.3549808859825134,
0.6488427519798279,
-0.567755937576294,
0.31481286883354187,
0.2894987165927887,
-0.0358487144112587,
0.11626099050045013,
-0.576166570186615,
1.0408796072006226,
-0.12368610501289368,
-0.29093554615974426,
-0.6552249193191528,
-0.15975309908390045,
0.03885520249605179,
-0.4211340546607971,
-0.5068542957305908,
0.1738879233598709,
0.020594600588083267,
0.17869576811790466,
-0.231542706489563,
-0.6185322999954224,
-0.29911261796951294,
0.8305631875991821,
0.26816922426223755,
0.22118157148361206,
0.3040555715560913,
-0.07464084774255753,
0.32740020751953125,
-0.09729917347431183,
-0.1390656679868698,
0.8935807943344116,
-0.00043141088099218905,
0.029730066657066345,
0.29262080788612366,
-0.3764534294605255,
0.7906801104545593,
0.04619273170828819,
0.3362288773059845,
0.2512032687664032,
0.37988972663879395,
-0.1978459507226944,
-0.07038288563489914,
0.20214933156967163,
-0.14735478162765503,
-0.0039947438053786755,
-0.3535451889038086,
-0.43770474195480347,
-0.005105908028781414,
0.09772899001836777,
-0.45886310935020447,
-0.7884982824325562,
-0.8852553367614746,
-0.09962660074234009,
-0.8810064792633057,
-0.07428763061761856,
-0.2288312017917633,
-0.6929652094841003,
-0.4364059269428253,
-0.6084875464439392,
0.558041512966156,
-0.12438374757766724,
0.31781482696533203,
-0.10440675169229507,
-0.014493114314973354,
0.6149990558624268,
-0.21280252933502197,
0.4379141926765442,
-0.340843141078949,
-0.39221546053886414,
0.25463321805000305,
-0.1564907729625702,
-0.3680088520050049,
0.7013465762138367,
-0.2050725817680359,
0.5339995622634888,
-0.12953327596187592,
0.11956803500652313,
-0.021250225603580475,
0.029507312923669815,
-0.23273712396621704,
0.28604164719581604,
0.53156977891922,
-0.1968846172094345,
-0.5192934274673462,
-0.5373443365097046,
-0.6627865433692932,
-0.4908386468887329,
-0.3732638955116272,
-0.6355279684066772,
-0.42311975359916687,
0.2696283459663391,
0.40135517716407776,
-0.5752655863761902,
0.13348188996315002,
-0.6801527738571167,
-0.8047696352005005,
0.07755871117115021,
-0.4241243004798889,
0.06281501799821854,
0.2953706383705139,
-0.6050129532814026,
0.287885457277298,
0.2012433409690857,
0.3078601062297821,
-0.21250253915786743,
-0.2656775712966919,
-0.37915778160095215,
0.3896958827972412,
-0.02961421012878418,
-0.09757618606090546,
0.35761961340904236,
0.3181881010532379,
-0.36362168192863464,
-0.4152107536792755,
-0.08349233865737915,
0.4299381673336029,
-0.5006693601608276,
-0.01787872239947319,
-0.22774472832679749,
0.3446999192237854,
0.009353486821055412,
0.1578732579946518,
0.34364956617355347,
-0.6490870714187622,
-0.3565695881843567,
-0.5500696897506714,
-0.41900721192359924,
0.32668185234069824,
0.2453116774559021,
0.3075304627418518,
-0.07189010083675385,
0.22970890998840332,
0.2518409788608551,
-0.05529876425862312,
-0.2826080322265625,
0.25910714268684387,
-0.25490647554397583,
1.5892950296401978,
-0.7516450881958008,
-0.35595136880874634,
1.5434216260910034,
0.3740200400352478,
0.07203622907400131,
0.24950022995471954,
0.06897233426570892,
0.756767213344574,
-0.47654610872268677,
-0.9448330998420715,
-0.00879373587667942,
-0.1166088655591011,
0.13192644715309143,
-0.5485810041427612,
0.09869317710399628,
0.6580637097358704,
-0.20639030635356903,
-0.2208532840013504,
-0.6841855049133301,
0.504780113697052,
-0.22329427301883698,
-0.4587034285068512,
0.04393116012215614,
-0.4547610282897949,
0.0020332136191427708,
0.6474836468696594,
-0.840410590171814,
0.17910122871398926,
1.037888765335083,
-0.1614471971988678,
0.493863970041275,
0.39403006434440613,
-0.005339985713362694,
1.3936816453933716,
-0.5728022456169128,
0.5649317502975464,
-0.8848713040351868,
0.102497898042202,
-0.47480010986328125,
-0.34653934836387634,
-0.11954029649496078,
0.0067562260664999485,
-0.2739713788032532,
0.4363778829574585,
-0.07455914467573166,
-0.0013125097611919045,
0.7157194018363953,
-0.7550733089447021,
0.08073891699314117,
0.321319043636322,
-0.632519006729126,
-0.3730257451534271,
-0.12323596328496933,
-0.6792163848876953,
0.18268872797489166,
0.11244897544384003,
0.5951625108718872,
0.35780391097068787,
-0.2607090473175049,
0.5174470543861389,
-0.10624367743730545,
0.1634436398744583,
0.18487083911895752,
0.09576918929815292,
-0.45460179448127747,
-0.007176284212619066,
-0.04214892536401749,
0.39919063448905945,
0.2526923716068268,
0.1275106817483902,
-0.5912848711013794,
-0.22210274636745453,
0.015641001984477043,
0.8910086154937744,
0.2352282851934433,
1.0161454677581787,
0.052035119384527206,
-0.25816574692726135,
0.024785403162240982,
-0.13417193293571472,
-0.4796510934829712,
0.43082380294799805,
0.8138892650604248,
-0.45286738872528076,
0.10739194601774216,
-0.035289205610752106,
-0.04789112135767937,
0.7455899715423584,
-0.20823349058628082,
-0.24197709560394287,
0.13941791653633118,
-0.3822765052318573,
-0.6371398568153381,
-0.6865566968917847,
-0.18974830210208893,
-0.42133381962776184,
0.292988121509552,
-0.05709816887974739,
0.1432981938123703,
0.26067352294921875,
-0.06786946952342987,
0.15540917217731476,
0.9286133646965027,
0.6848740577697754,
-0.6127536296844482,
-0.14750301837921143,
0.33123379945755005,
-0.7290421724319458,
0.22471566498279572,
0.054074931889772415,
0.3529130816459656,
-0.3935486376285553,
0.2209973782300949,
-5.5447893142700195,
-0.2300388216972351,
0.3058789074420929,
0.015620199032127857,
-0.12294367700815201,
0.10483478009700775,
1.0423630475997925,
-0.3024468719959259,
0.0966959223151207,
0.5554177165031433,
0.6483944654464722,
0.2681976556777954,
0.20672044157981873,
-0.3177938759326935,
-0.7421613931655884,
-0.1840028315782547,
-0.6146739721298218,
0.266713947057724,
0.18001697957515717,
-0.0071752918884158134,
0.4473307728767395,
0.054030243307352066,
-0.3160383701324463,
0.8138164281845093,
-0.11780305951833725,
-0.2237226963043213,
-0.47052139043807983,
0.49801263213157654,
0.11012447625398636,
-0.06998999416828156,
0.48434409499168396,
-0.7962183356285095,
-0.10598642379045486,
0.39280277490615845,
0.15576164424419403,
-0.009856129065155983,
0.005111834034323692,
-0.3882681131362915,
0.009913462214171886,
-0.4090002477169037,
-0.22046349942684174,
-0.17385993897914886,
-0.12613661587238312,
-0.38634800910949707,
-0.271944522857666,
-0.5642262697219849,
-0.05041952803730965,
0.23849214613437653,
-0.06171853467822075,
0.6363295912742615,
-0.17310597002506256,
-0.08784987032413483,
-0.020481280982494354,
0.8527354598045349,
0.9971826672554016,
0.41715380549430847,
-0.17746266722679138,
-0.06723221391439438,
-0.4345141351222992,
0.4179970622062683,
-0.07383555918931961,
0.22327138483524323,
-0.5570852160453796,
-0.5054309368133545,
0.30621829628944397,
0.2826423645019531,
-0.6075943112373352,
-0.8060311675071716,
0.5849815011024475,
-0.13861878216266632,
-0.11656907945871353,
0.24295870959758759,
0.10965726524591446,
-0.6931861639022827,
0.398765504360199,
-0.3645322918891907,
0.6045758128166199,
0.02160831168293953,
-0.24650323390960693,
-0.21297386288642883,
-0.6067178845405579,
0.07671879976987839,
-0.15171276032924652,
-0.2644704282283783,
-0.0451577827334404,
-0.0913584753870964,
-0.1301223784685135,
-0.16285213828086853,
0.12079007178544998,
0.45460936427116394,
0.3497719466686249,
-0.3777467906475067,
-0.1767003834247589,
0.43918293714523315,
-0.16220329701900482,
0.38639944791793823,
0.0784032791852951,
0.7632084488868713,
1.172577977180481,
0.16065694391727448,
0.9057661890983582,
-0.08045852184295654,
-0.4100748300552368,
-0.5508427619934082,
-0.010508811101317406,
0.2550339996814728,
-0.005280687939375639,
-0.3197252154350281,
1.7295886278152466,
-0.9127731919288635,
0.1823761761188507,
0.13175266981124878,
-0.14515340328216553,
-0.08976780623197556,
0.5110073089599609,
-0.40932992100715637,
-0.0558883398771286,
0.2878594696521759,
0.5657387971878052,
-0.18206481635570526,
0.3404087424278259,
0.2960425317287445,
-0.6309178471565247,
0.2753944396972656,
0.36939001083374023,
0.3291362524032593,
0.2538875341415405,
0.13752491772174835,
-0.7033187747001648,
-0.32196536660194397,
0.55657958984375,
-0.14832933247089386,
-0.2354479730129242,
0.4577568471431732,
0.4479721784591675,
-0.5851383805274963,
0.03599797189235687,
0.13081945478916168,
0.5908282399177551,
-0.003449058858677745,
0.12377467751502991,
-0.39449024200439453,
-0.28392234444618225,
-0.33120501041412354,
0.7225815653800964,
0.15207742154598236,
-0.39100611209869385,
-0.26218461990356445,
-0.4198475778102875,
-0.4643676280975342,
0.18268272280693054,
0.22768904268741608,
0.003304577199742198,
0.08639157563447952,
-0.6406635046005249,
0.4136735498905182,
0.503318190574646,
-0.11824741214513779,
0.09153753519058228,
-0.413076251745224,
0.3863180875778198,
0.33387133479118347,
-0.916755199432373,
-0.4299785792827606,
-0.1554841846227646,
-0.356752872467041,
-0.3854259252548218,
-0.4442225694656372,
0.24389073252677917,
0.20194000005722046,
-0.24587072432041168,
-0.15376098453998566,
-0.3625720143318176,
-0.42126014828681946,
-0.11213338375091553,
-0.1812872290611267,
-0.4528966248035431,
0.1786268651485443,
-0.1514396220445633,
0.6347150206565857,
0.19690537452697754,
-0.3536052405834198,
-0.2683738172054291,
0.5905527472496033,
0.3320823609828949,
-0.12392405420541763,
-0.1256915032863617,
0.006466133985668421,
-0.262825071811676,
-0.4735276699066162,
0.20731356739997864,
-0.02785460837185383,
-0.06772629916667938,
-0.30479103326797485,
0.43987685441970825,
0.3237248361110687,
-0.32011672854423523,
-0.3528980612754822,
-0.06365770101547241,
-0.36576834321022034,
-0.19207322597503662,
0.17317765951156616,
-0.30145832896232605,
0.3007158637046814,
-0.21783579885959625,
-0.026851454749703407,
-0.26506906747817993,
0.051142241805791855,
-0.08151261508464813,
0.0058859060518443584,
0.011301310732960701,
-0.7585378289222717,
0.4556870758533478,
0.7815409898757935,
0.3299548625946045,
0.00848612654954195,
-0.18478688597679138,
-0.32553473114967346,
0.008939387276768684,
-0.028169400990009308,
0.29592424631118774,
0.07849904149770737,
0.3750901222229004,
0.019507015123963356,
-0.6140719056129456,
0.3890417814254761,
0.1524670422077179,
-0.769625723361969,
0.142637237906456,
0.31240445375442505,
0.01244250126183033,
0.04393753781914711,
-0.06665708124637604,
0.3994391858577728,
-0.4436880648136139,
-0.6373670101165771,
-0.3221074938774109,
-0.06622358411550522,
-0.12644051015377045,
0.6798848509788513,
0.24187560379505157,
0.6185873746871948,
-0.2952546179294586,
0.01354223396629095,
0.2978634536266327,
0.473427951335907,
0.4356255829334259,
-0.8267558813095093,
-0.47641175985336304,
0.33503010869026184,
0.2500840723514557,
-0.048277873545885086,
0.06227879226207733,
0.256577730178833,
0.8180121779441833,
0.022225525230169296,
0.09826730191707611,
-0.08943026512861252,
-0.4712328314781189,
0.14901159703731537,
-0.08669446408748627,
0.09405407309532166,
-0.4936922788619995,
0.1271343231201172,
-0.07624056935310364,
-0.19103913009166718,
-0.520287811756134,
-0.6608820557594299,
0.33350393176078796,
-0.20219029486179352,
-0.0461566261947155,
-0.1233016774058342,
1.1114881038665771,
0.7221541404724121,
-0.15046440064907074,
0.2648283839225769,
-0.19765113294124603,
-0.10286833345890045,
-0.2607255280017853,
0.43066301941871643,
-0.05041983723640442,
-0.6676735281944275,
-0.003417127998545766,
-0.38823679089546204,
0.6642401814460754,
-0.650336742401123,
-0.0023958319798111916,
-0.398741215467453,
-0.1113104522228241,
-0.37697833776474,
-0.33967846632003784,
0.3280229866504669,
-0.6863073706626892,
-0.10190493613481522,
-0.05420016497373581,
0.21451438963413239,
-0.009017940610647202,
0.43990007042884827,
-0.411117285490036,
0.08651431649923325,
-0.6245250105857849,
0.569863498210907,
0.41309645771980286,
-0.29573023319244385,
-0.14239470660686493,
-0.04704355075955391,
0.07229416817426682,
0.17570924758911133,
-0.2322371006011963,
-0.4358903169631958,
0.14737193286418915,
-0.32559508085250854,
0.31199973821640015,
0.4743586480617523,
-0.21408769488334656,
0.5463628172874451,
-0.0470658540725708,
-0.16485828161239624,
0.715874195098877,
0.22391003370285034,
0.009457330219447613,
0.7867976427078247,
0.4979592263698578,
-0.0608687624335289,
-0.39086154103279114,
0.396680623292923,
0.08370000123977661,
0.41077789664268494,
-0.029480185359716415,
1.0987751483917236,
0.5077372789382935,
0.08196823298931122,
0.1806710958480835,
0.45141100883483887,
0.4199477732181549,
-0.44201940298080444,
0.2770788371562958,
-0.6978325247764587,
-0.3884738087654114,
-0.1135597825050354,
0.9193975925445557,
0.37324997782707214,
0.24690334498882294,
0.10039685666561127,
-0.03998873382806778,
0.5147518515586853,
0.3142647445201874,
0.9385403394699097,
0.046724334359169006,
-0.23920629918575287,
0.035523999482393265,
0.02204723469913006,
0.0200254637748003,
-0.29360195994377136,
-0.5757131576538086,
0.6438290476799011,
0.7668834328651428,
-0.33392465114593506,
-0.4376431107521057,
0.3869979679584503,
-0.17528855800628662,
0.0455433614552021,
0.33662810921669006,
0.58903568983078,
-0.16799396276474,
-0.1357671469449997,
0.22220340371131897,
-0.0389697402715683,
0.13756385445594788,
-0.31436556577682495,
-0.02264547534286976,
-0.08194981515407562,
-0.40729275345802307,
0.2820088267326355,
0.7055428624153137,
-0.40678274631500244,
0.18781188130378723,
-0.14232505857944489,
0.029157716780900955,
0.5394982099533081,
-0.03518008440732956,
0.011691365391016006,
-0.329087495803833,
-0.674180805683136,
-0.11946247518062592,
-0.07867229729890823,
-0.38167282938957214,
-0.17500722408294678,
0.4103279411792755,
0.2640719413757324,
0.026439808309078217,
-0.013104175217449665,
0.42544302344322205,
0.12424276769161224,
0.37997639179229736,
-0.1759912073612213,
0.26930686831474304,
0.3906513452529907,
-0.05954646319150925,
0.36639541387557983,
-0.22348979115486145,
0.6181305050849915,
-0.29402846097946167,
-0.06727752089500427,
-0.6731691360473633,
0.3622131645679474,
0.02451195754110813,
-0.005817287601530552,
-0.5217669606208801,
-0.09863349795341492,
1.132001519203186,
0.48813557624816895,
-0.16193634271621704,
0.09482661634683609,
0.13459834456443787,
-0.22619952261447906,
0.27199605107307434,
-0.36514681577682495,
-0.24124658107757568,
-0.74540114402771,
-0.2702637314796448,
-0.20818890631198883,
0.44651660323143005,
-0.16929090023040771,
-0.3877880573272705,
0.29323872923851013,
0.7750506401062012,
0.4375806152820587,
-0.2805686295032501,
0.21695412695407867,
-0.4158220589160919,
-0.24907131493091583,
-0.7795630097389221,
0.31091728806495667,
-0.3800674080848694,
-0.09432993084192276,
-0.36885714530944824,
0.16673476994037628,
0.23410165309906006,
0.14794664084911346,
0.5151121616363525,
-0.6181486248970032,
0.08964855968952179,
-0.33288833498954773,
0.2886616587638855,
0.24799992144107819,
-0.5387976169586182,
-0.5153000950813293,
-0.3015647530555725,
0.3759017884731293,
0.2479211539030075,
-0.8716341257095337,
-0.004780179355293512,
0.16956743597984314,
-0.21281388401985168,
-0.1261257529258728,
-0.07615357637405396,
-0.04550439119338989,
-0.41621604561805725,
-0.38115236163139343
] |
In felids, feline leukemia virus (FeLV) infection results in a variety of outcomes that range from abortive (virus readily eliminated and never detectable) to progressive infection (persistent viremia and viral shedding). Recently, a novel outcome was postulated for low FeLV infectious doses. Naïve cats exposed to faeces of persistently infected cats seroconverted, indicating infection, but remained negative for provirus and p27 antigen in blood. FeLV provirus was found in some tissues but not in the bone marrow, infection of which is usually considered a necessary stage for disease progression. To investigate the impact of low FeLV doses on young cats and to test the hypothesis that low dose exposure may lead to an unknown pathogenesis of infection without involvement of the bone marrow, 21 cats were infected oronasally with variable viral doses. Blood p27, proviral and viral loads were followed until week 20 post-infection. Tissue proviral loads were determined as well. The immune response was monitored by measuring FeLV whole virus and p45 antibodies; and feline oncornavirus-associated cell membrane antigen (FOCMA) assay. One cat showed regressive infection (transient antigenemia, persistent provirus-positivity, and seroconversion) with provirus only found in some organs at sacrifice. In 7 of the 20 remaining cats FOCMA assay positivity was the only sign of infection, while all other tests were negative. Overall, the results show that FeLV low dose exposure can result in seroconversion during a presumed abortive infection. Therefore, commonly used detection methods do not detect all FeLV-infected animals, possibly leading to an underestimation of the prevalence of infection. | [
0.0010780650191009045,
0.01223656628280878,
-0.0008637835271656513,
0.016544464975595474,
-0.00839090347290039,
-0.013527183793485165,
0.009993881918489933,
0.009528297930955887,
-0.016211990267038345,
-0.007658099289983511,
-0.006482294760644436,
0.012464518658816814,
-0.006334757432341576,
0.0066758450120687485,
0.0020715873688459396,
0.00565152894705534,
0.005081517156213522,
-0.006317391060292721,
0.0038041151128709316,
-0.024247869849205017,
0.0008953660726547241,
-0.023407138884067535,
0.01026027649641037,
-0.003433133941143751,
-0.04174993559718132,
-0.01653939113020897,
-0.013317743316292763,
-0.002007956150919199,
0.025425661355257034,
0.012669400312006474,
0.006789920385926962,
0.009230286814272404,
-0.007539546582847834,
0.010418456047773361,
0.019293423742055893,
0.028225991874933243,
-0.00046922219917178154,
0.020813271403312683,
-0.017511531710624695,
-0.0034564859233796597,
0.00240872404538095,
-0.005429541226476431,
0.007697358727455139,
-0.005167561583220959,
-0.006558680906891823,
-0.007868439890444279,
-0.0035480617079883814,
-0.008131295442581177,
-0.014050687663257122,
0.00047567678848281503,
-0.005156479775905609,
0.005437246523797512,
-0.014422312378883362,
0.022807838395237923,
-0.0072902292013168335,
-0.011627709493041039,
0.021293843165040016,
-0.032606180757284164,
-0.01140996627509594,
0.02074940875172615,
0.03421444818377495,
0.02242451347410679,
0.004618785344064236,
0.015362916514277458,
0.0256049707531929,
-0.06661312282085419,
0.007609388325363398,
0.000006831367500126362,
0.005718199536204338,
0.004000500775873661,
0.004742474295198917,
0.0005278590833768249,
0.02807522565126419,
-0.030531272292137146,
-0.016330508515238762,
-0.015952780842781067,
-0.019428107887506485,
0.035983435809612274,
-0.003109320066869259,
0.011317210271954536,
0.02804754301905632,
-0.002989661181345582,
-0.0017239777371287346,
0.024312853813171387,
-0.02695414423942566,
0.02077021822333336,
-0.031710103154182434,
-0.004717401694506407,
-0.003960383124649525,
-0.016199838370084763,
0.011219251900911331,
-0.025672748684883118,
-0.04404263198375702,
0.03763723373413086,
0.009914807975292206,
-0.02383488416671753,
-0.024933625012636185,
-0.037315934896469116,
0.021891886368393898,
-0.02213674783706665,
-0.009953435510396957,
-0.008590470999479294,
0.014824898913502693,
0.0055382433347404,
0.009823756292462349,
0.008891245350241661,
0.006141006946563721,
-0.019901346415281296,
0.02200516313314438,
0.0160873681306839,
0.015152020379900932,
-0.014470300637185574,
0.009663807228207588,
0.008048517629504204,
-0.01157291978597641,
0.015050409361720085,
-0.011186922900378704,
0.014575045555830002,
-0.002837034175172448,
-0.014963215216994286,
0.015800973400473595,
0.01794775202870369,
0.01001677755266428,
-0.030340060591697693,
0.007865892723202705,
-0.02063508704304695,
0.013082597404718399,
-0.05000954866409302,
0.042052824050188065,
0.0010055305901914835,
-0.005255463533103466,
0.015015270560979843,
0.007557420060038567,
-0.031709715723991394,
0.019459301605820656,
0.0047029489651322365,
0.019678547978401184,
0.0012244577519595623,
0.008837023749947548,
-0.028405286371707916,
-0.022697003558278084,
0.009481800720095634,
0.004522687755525112,
0.015643566846847534,
-0.007281776983290911,
0.003968049306422472,
0.007612002082169056,
0.013749551959335804,
0.033523038029670715,
0.008229926228523254,
-0.00804951786994934,
-0.010949968360364437,
0.009072879329323769,
0.0004701758734881878,
-0.010182829573750496,
-0.012501430697739124,
-0.0286067184060812,
0.01498958095908165,
0.02043573558330536,
-0.0006276825442910194,
0.009148888289928436,
0.0012992913834750652,
0.026066485792398453,
0.010479243472218513,
0.03226392716169357,
0.010944129899144173,
0.030030902475118637,
-0.018694408237934113,
-0.008116662502288818,
0.004145239945501089,
0.000601417850703001,
0.001389823155477643,
-0.01569315232336521,
0.007416608743369579,
0.011614463292062283,
-0.00868929736316204,
0.013274131342768669,
0.007196530699729919,
-0.0108382198959589,
0.06608446687459946,
0.009072226472198963,
0.02218710631132126,
-0.005560160614550114,
-0.029821082949638367,
0.009843800216913223,
0.010082335211336613,
0.03965533897280693,
-0.011777359992265701,
0.02796097658574581,
0.016338832676410675,
-0.0150409871712327,
-0.0010347305797040462,
0.013691948726773262,
-0.03046368435025215,
0.010915732942521572,
0.003449485870078206,
0.001589735969901085,
0.010436329059302807,
0.004509581718593836,
0.005806289613246918,
0.021212641149759293,
-0.017130129039287567,
0.014404091984033585,
0.003544418141245842,
-0.041067756712436676,
0.017291104421019554,
0.011307336390018463,
-0.028237152844667435,
0.007600036449730396,
0.03522645682096481,
0.03160882368683815,
0.037304580211639404,
0.00018340116366744041,
-0.032448168843984604,
-0.002939967904239893,
-0.0011770006967708468,
0.01899905316531658,
0.0015485105104744434,
0.02852627821266651,
-0.016960032284259796,
0.004496371373534203,
-0.003266872838139534,
-0.019808810204267502,
0.0024456321261823177,
-0.00028232031036168337,
-0.0018696058541536331,
0.007258608005940914,
0.010972116142511368,
-0.02624763734638691,
0.001996906939893961,
0.00034046941436827183,
-0.02409786731004715,
-0.008612260222434998,
0.027144987136125565,
0.016266388818621635,
-0.009758846834301949,
0.012005536817014217,
-0.031280357390642166,
0.019902866333723068,
-0.01901390217244625,
0.001978882122784853,
0.021201282739639282,
-0.01371839176863432,
-0.03825125843286514,
0.028082948178052902,
-0.030424920842051506,
0.02302301675081253,
0.00034568936098366976,
-0.012232903391122818,
-0.023754600435495377,
0.01003748644143343,
0.019155997782945633,
-0.0035712439566850662,
-0.02755769155919552,
0.004757808055728674,
-0.02875285968184471,
0.03366348147392273,
0.016381220892071724,
0.028324630111455917,
0.008697077631950378,
0.008714928291738033,
0.006141176447272301,
0.01786048896610737,
-0.002119341865181923,
0.0015763106057420373,
0.0041037024930119514,
-0.0045439815148711205,
0.0021058344282209873,
0.044746991246938705,
0.013324607163667679,
0.0054200016893446445,
-0.0029290937818586826,
-0.010400058701634407,
-0.08141063898801804,
-0.012990767136216164,
-0.01659674197435379,
-0.0014496000949293375,
0.007595514878630638,
0.019117655232548714,
0.009559303522109985,
-0.01478275191038847,
-0.007503720000386238,
-0.000592212425544858,
0.023593883961439133,
0.017689786851406097,
-0.002431258326396346,
-0.008958638645708561,
0.01640472747385502,
-0.0003090851241722703,
0.003033603308722377,
-0.012118813581764698,
-0.022631345316767693,
0.023165985941886902,
-0.02454780973494053,
-0.012008839286863804,
0.03357895463705063,
-0.004774910863488913,
-0.005548278335481882,
0.04411926120519638,
0.02046160027384758,
0.00804856512695551,
0.025288138538599014,
0.009819705039262772,
0.01151380967348814,
-0.018090149387717247,
0.03232555091381073,
-0.011168134398758411,
0.0378912128508091,
-0.018542371690273285,
-0.007448648102581501,
-0.011144482530653477,
-0.02439861185848713,
-0.003697538748383522,
-0.023024670779705048,
0.007109466008841991,
0.002602322492748499,
0.0013743694871664047,
0.019462473690509796,
-0.012805539183318615,
0.0303725004196167,
-0.018468676134943962,
0.018125366419553757,
0.02634330280125141,
0.00013705831952393055,
0.0013381191529333591,
-0.01677064597606659,
0.016074977815151215,
-0.020011145621538162,
-0.0006209256825968623,
-0.015834979712963104,
-0.012011945247650146,
-0.01237128023058176,
-0.020241566002368927,
0.015805598348379135,
-0.0037257452495396137,
0.029362929984927177,
0.03292788192629814,
0.007455982267856598,
0.05201687291264534,
0.028888819739222527,
0.029405072331428528,
0.006947667337954044,
0.026770705357193947,
0.00623200973495841,
-0.005888126790523529,
-0.008643342182040215,
-0.00444262707605958,
-0.0023661598097532988,
-0.0008425440173596144,
-0.01669861376285553,
-0.011173760518431664,
-0.030997343361377716,
-0.006064082961529493,
-0.04262178763747215,
0.0002532472717575729,
0.013877509161829948,
0.01063423790037632,
-0.016918446868658066,
0.00911905150860548,
0.012108288705348969,
0.01725475862622261,
0.014380648732185364,
-0.021745629608631134,
0.03883827477693558,
-0.020692024379968643,
-0.017046408727765083,
0.01179615966975689,
-0.02991904690861702,
-0.025296589359641075,
-0.007225831970572472,
-0.0018625874072313309,
0.008801005780696869,
0.0089039895683527,
-0.0182816032320261,
-0.01197053398936987,
-0.018027646467089653,
-0.0033671753481030464,
0.009730475023388863,
0.015718597918748856,
0.02453516237437725,
0.029899530112743378,
-0.020733557641506195,
-0.014432230964303017,
0.007551141548901796,
0.007664777804166079,
-0.004050690680742264,
-0.0158856064081192,
0.007058064453303814,
0.02399527281522751,
0.01192539744079113,
-0.018087971955537796,
0.0711020976305008,
0.03157079964876175,
0.009100337512791157,
-0.016387812793254852,
-0.0200959499925375,
-0.01757255382835865,
-0.01129147782921791,
-0.001954388804733753,
-0.005451650358736515,
-0.016881292685866356,
0.015504555776715279,
-0.02682231366634369,
-0.002209577476605773,
-0.027050577104091644,
-0.02030339278280735,
-0.001632819650694728,
0.019727732986211777,
-0.02380477637052536,
-0.015221762470901012,
0.007566823624074459,
0.02659991756081581,
0.0060483491979539394,
0.018322331830859184,
-0.016306821256875992,
0.0492691844701767,
-0.009101019240915775,
0.02995988167822361,
-0.01515461876988411,
-0.03228427842259407,
0.0061393724754452705,
-0.0298751313239336,
-0.0016950098797678947,
-0.004072322975844145,
-0.014164261519908905,
0.038620274513959885,
-0.009289141744375229,
-0.010906141251325607,
0.025673996657133102,
0.009787839837372303,
-0.008982078172266483,
-0.009969777427613735,
-0.01523374393582344,
0.002262700814753771,
0.01132357120513916,
-0.020654959604144096,
-0.03273771330714226,
0.010011529549956322,
-0.00841161422431469,
-0.010541285388171673,
-0.021072326228022575,
-0.006226482801139355,
0.00348288775421679,
0.011854410171508789,
0.02763477712869644,
0.011808022856712341,
-0.03417586535215378,
0.008637994527816772,
-0.00192294514272362,
-0.01925228349864483,
-0.0199802964925766,
0.0013287675101310015,
0.0013469092082232237,
-0.007129128556698561,
-0.017516594380140305,
0.007636103313416243,
-0.012197424657642841,
-0.0031860165763646364,
-0.007382599636912346,
0.02834082581102848,
-0.01234130747616291,
0.042936697602272034,
0.01222324464470148,
-0.0007938903290778399,
-0.016598239541053772,
-0.02891198918223381,
0.03144416585564613,
-0.0003377217799425125,
0.002925785258412361,
0.019996456801891327,
-0.010350583121180534,
0.005578779615461826,
-0.02031877636909485,
0.01474106777459383,
-0.022715317085385323,
0.005503579042851925,
-0.009115982800722122,
0.004376616328954697,
-0.07433156669139862,
-0.0019953653682023287,
0.017904765903949738,
-0.009309710003435612,
0.0010631391778588295,
-0.02067573368549347,
-0.02139105461537838,
-0.008313940837979317,
-0.04770379140973091,
-0.007493101060390472,
-0.01184646412730217,
-0.03737957775592804,
0.0237701628357172,
0.009348608553409576,
0.011648513376712799,
-0.03326557204127312,
-0.0052606090903282166,
0.004716955125331879,
-0.023139920085668564,
-0.005837775766849518,
0.011417622677981853,
0.004890736658126116,
0.011477638967335224,
0.010767405852675438,
0.008406899869441986,
-0.08007927983999252,
0.022151464596390724,
-0.015281202271580696,
-0.018938429653644562,
0.013081107288599014,
-0.0432707853615284,
-0.008524060249328613,
-0.027716029435396194,
0.0017890866147354245,
-0.01991369016468525,
-0.0004151437897235155,
-0.012797108851373196,
-0.013112873770296574,
0.010685407556593418,
0.029044440016150475,
-0.007533608935773373,
0.006603950168937445,
0.008848888799548149,
-0.0036766473203897476,
0.011775548569858074,
0.0046252598986029625,
-0.001963839866220951,
-0.005658172070980072,
0.0026655462570488453,
-0.010060306638479233,
0.018639378249645233,
-0.03346652910113335,
0.009326459839940071,
-0.02237345278263092,
0.010045715607702732,
-0.011010976508259773,
-0.006209765560925007,
0.0031213012989610434,
-0.0024793418124318123,
0.013946844264864922,
-0.005037984810769558,
0.008253298699855804,
-0.0054924581199884415,
-0.0015217354521155357,
0.011086026206612587,
-0.00006922025931999087,
-0.009423001669347286,
-0.0021377610974013805,
-0.004210271406918764,
-0.007247537840157747,
-0.00999375618994236,
0.00299473712220788,
-0.017060332000255585,
0.018338274210691452,
0.0061967745423316956,
0.01117710955440998,
-0.019297001883387566,
-0.0016870577819645405,
0.009461060166358948,
-0.032650820910930634,
-0.015427151694893837,
-0.007935174740850925,
0.013990405946969986,
-0.00981984380632639,
0.008734296075999737,
0.0018261868972331285,
-0.002534580649808049,
0.015050029382109642,
0.0709047019481659,
-0.01861928403377533,
0.011538089253008366,
-0.042594537138938904,
0.004000216722488403,
-0.0005264661740511656,
-0.00004705972969532013,
0.012907825410366058,
-0.005527004599571228,
-0.022341415286064148,
-0.018787380307912827,
-0.007224786560982466,
0.00837407074868679,
0.009412851184606552,
0.002364169340580702,
0.008343332447111607,
0.0062419637106359005,
0.022559162229299545,
-0.004110129550099373,
0.004164217039942741,
0.008232023566961288,
0.009064559824764729,
-0.01556984893977642,
-0.022499797865748405,
0.027504080906510353,
0.004946107976138592,
-0.004976507741957903,
0.0032585831359028816,
0.003998847678303719,
-0.014672305434942245,
-0.011976276524364948,
0.018786795437335968,
0.0019848656374961138,
-0.038396287709474564,
-0.007791790645569563,
-0.004915189929306507,
-0.003917019348591566,
0.0034440208692103624,
0.00988407526165247,
0.02757701650261879,
-0.01575387455523014,
-0.01218736544251442,
-0.006034905556589365,
-0.030383538454771042,
-0.0012329157907515764,
0.010558966547250748,
0.030553046613931656,
-0.024438850581645966,
0.009155157953500748,
0.01126785296946764,
0.0044396244920790195,
0.027462497353553772,
0.01752910017967224,
-0.01186774205416441,
-0.015350429341197014,
-0.009330914355814457,
-0.022874251008033752,
0.016986936330795288,
-0.015246217139065266,
-0.01329593826085329,
-0.0030683232471346855,
-0.01386796124279499,
-0.01421284582465887,
-0.020108528435230255,
0.001003046054393053,
-0.02738846093416214,
-0.0025257389061152935,
-0.025482945144176483,
-0.03242212533950806,
0.01936357654631138,
-0.015402082353830338,
0.0012870263308286667,
0.004194040782749653,
0.0013043622020632029,
0.011147083714604378,
-0.0024115676060318947,
0.039403773844242096,
0.023749589920043945,
0.0020485701970756054,
0.009346961975097656,
-0.01659032329916954,
0.0100881177932024,
-0.009220837615430355,
0.004439644981175661,
0.02267102524638176,
0.0023850963916629553,
0.0220332071185112,
-0.020555447787046432,
-0.0057488856837153435,
-0.0007829454261809587,
0.01592966541647911,
-0.003813466988503933,
-0.005485291592776775,
0.02544737234711647,
0.0017309889663010836,
0.0366617850959301,
-0.014261381700634956,
0.010960392653942108,
0.002276585903018713,
-0.0054176198318600655,
-0.026903100311756134,
0.0014032479375600815,
0.003784768283367157,
-0.000028768670745193958,
0.008096342906355858,
-0.007219912484288216,
0.005815121345221996,
0.007370626553893089,
0.004729000851511955,
0.03081410750746727,
0.02348395064473152,
-0.01093777734786272,
0.010619038715958595,
-0.0068444241769611835,
0.015381086617708206,
-0.019511250779032707,
-0.017623914405703545,
-0.004517544526606798,
-0.03175904229283333,
-0.004382878076285124,
-0.01035605650395155,
-0.008900731801986694,
0.01284186914563179,
0.0026752285193651915,
-0.016405200585722923,
-0.022514648735523224,
-0.009589644148945808,
-0.028003334999084473,
-0.014963016845285892,
0.0004440015181899071,
0.02358732372522354,
-0.0182941984385252,
-0.007770073134452105,
0.02252129279077053,
-0.008144430816173553,
0.009126922115683556,
0.03679559379816055,
0.006489241495728493,
0.012139086611568928,
-0.02217143401503563,
-0.005145232193171978,
-0.0016416963189840317,
0.0027210074476897717,
-0.025131795555353165,
0.006992597132921219,
-0.00254011619836092,
-0.0031076776795089245,
0.039726488292217255,
0.014296735636889935,
0.009277171455323696,
-0.006834410130977631,
0.013008633628487587,
0.005559386685490608,
-0.00911018718034029,
0.007966931909322739,
0.010598287917673588,
0.008920220658183098,
-0.012663131579756737,
-0.008479725569486618,
0.014157655648887157,
0.020386159420013428,
-0.004025227855890989,
0.0019028815440833569,
-0.006423248443752527,
-0.0021564520429819822,
0.038264140486717224,
0.0073961238376796246,
0.01760271191596985,
0.010838923044502735,
0.03597831726074219,
0.0031395014375448227,
-0.024263544008135796,
0.007795705925673246,
0.02587873488664627,
-0.000008777715265750885,
-0.009122900664806366,
-0.004744339268654585,
0.022951623424887657,
0.0005702434573322535,
0.008427053689956665,
0.00013771792873740196,
-0.019261810928583145,
-0.0016253627836704254,
-0.007760005071759224,
-0.00448012538254261,
0.014107365161180496,
0.0014465705025941133,
0.01771978661417961,
-0.0014995825476944447,
-0.004656630102545023,
-0.007609392516314983,
-0.00034871604293584824,
0.006437418982386589,
0.006765440572053194,
-0.005096063483506441,
0.009404698386788368,
-0.0178344938904047,
-0.0550568625330925,
0.0007401523180305958,
0.019995270296931267,
0.043155524879693985,
-0.009028053842484951
] | [
0.22467409074306488,
-0.25046563148498535,
-0.1301816999912262,
-0.2578076124191284,
-0.11629592627286911,
0.3778441548347473,
0.8636142611503601,
0.12829895317554474,
0.10699012130498886,
-0.5497676134109497,
-0.25534480810165405,
-0.1535433977842331,
-0.8211212158203125,
0.1419096738100052,
-0.08058909326791763,
0.49016863107681274,
0.6274833679199219,
0.39343541860580444,
-0.6019002795219421,
-0.3446286618709564,
-0.2446259707212448,
-0.5091239809989929,
0.3511723577976227,
0.020514145493507385,
0.05661916360259056,
-0.31006181240081787,
0.5533238649368286,
0.40134280920028687,
0.19728007912635803,
-0.07316756248474121,
0.0311734601855278,
0.5833014845848083,
0.09426332265138626,
-0.5192005634307861,
-0.6348621249198914,
0.21838802099227905,
-0.05249648913741112,
-0.3645269572734833,
0.0014835384208709002,
-0.24652302265167236,
-0.10385752469301224,
-0.15272511541843414,
0.0698954239487648,
0.48329877853393555,
-0.14969630539417267,
-0.6137775778770447,
-1.4818518161773682,
0.4517596662044525,
-0.04343024641275406,
-0.019378172233700752,
0.03946064040064812,
-0.0919828936457634,
-0.3888225853443146,
0.005077327135950327,
0.38881006836891174,
0.4595150053501129,
-0.9179572463035583,
-0.1497822105884552,
0.161821186542511,
-0.19782765209674835,
0.40228497982025146,
0.015803394839167595,
-0.1488545835018158,
0.3896343410015106,
-0.5661306381225586,
0.3734849989414215,
0.2754102051258087,
0.45530077815055847,
-0.4067070186138153,
-0.4389578700065613,
-0.007350703235715628,
-0.22584907710552216,
-0.04335138574242592,
-0.1078481674194336,
0.21335624158382416,
0.015955185517668724,
-0.5495489835739136,
-0.4270015358924866,
0.44154080748558044,
0.2680134177207947,
-0.14104829728603363,
0.43637755513191223,
0.4633277654647827,
-0.024341842159628868,
0.6124769449234009,
0.1353711485862732,
0.038383182138204575,
0.8685827851295471,
-0.39127790927886963,
0.4093484878540039,
0.10624013841152191,
-0.10583643615245819,
0.6674720644950867,
0.3393847346305847,
0.2345069795846939,
0.29789820313453674,
0.28067123889923096,
-0.04592883214354515,
0.3396649956703186,
0.0089291175827384,
-0.5201972126960754,
0.08026245981454849,
-0.5482343435287476,
-0.10754652321338654,
-0.3402952551841736,
-0.29633432626724243,
-0.422974556684494,
-0.5009339451789856,
-0.5312421917915344,
-0.21422168612480164,
-0.782163143157959,
-0.3893343210220337,
-0.09008897095918655,
-0.12725095450878143,
-0.32197049260139465,
0.16921870410442352,
0.03353152051568031,
-0.34679606556892395,
-0.14040258526802063,
0.12504076957702637,
-0.06037502735853195,
0.4877801835536957,
-0.32765665650367737,
0.03610331565141678,
-0.35618075728416443,
-0.36001914739608765,
0.39146295189857483,
0.3576027750968933,
-0.05065867304801941,
0.9026177525520325,
0.16564172506332397,
0.5955323576927185,
-0.3865361511707306,
-0.04995526000857353,
0.43226370215415955,
-0.2882862687110901,
-0.00639162864536047,
-0.10053036361932755,
0.012891096994280815,
0.03749784827232361,
-0.7713256478309631,
-0.21987968683242798,
-0.1953875720500946,
0.4630564749240875,
-0.19605962932109833,
-0.11867956817150116,
-0.4035934805870056,
0.5514360070228577,
-0.24731892347335815,
-0.27914050221443176,
0.1633312702178955,
0.09375539422035217,
-0.20371367037296295,
0.09978512674570084,
-0.25421348214149475,
0.580241322517395,
0.04337868466973305,
-0.37993693351745605,
-0.29314741492271423,
0.19379822909832,
0.37552282214164734,
0.48409461975097656,
-0.07894153892993927,
-0.32102471590042114,
0.525105357170105,
-0.0779678151011467,
0.1849544644355774,
0.6690069437026978,
-0.15805719792842865,
0.0076638334430754185,
-0.22973313927650452,
-0.04125984013080597,
0.15359194576740265,
-0.2553832530975342,
0.11742328852415085,
0.16371800005435944,
0.1672416776418686,
-0.09955929219722748,
0.05254139006137848,
0.3543635606765747,
-0.6488106846809387,
0.023595264181494713,
0.05392347648739815,
0.07512414455413818,
0.5410364270210266,
0.1586606353521347,
0.2945537865161896,
-0.2722413241863251,
-0.3829684853553772,
-0.5436102747917175,
-0.3875483274459839,
-0.2059185802936554,
0.855299174785614,
-0.0643620416522026,
1.4761704206466675,
-0.2896163761615753,
-0.638052761554718,
1.2860772609710693,
0.006679547019302845,
0.12052826583385468,
-0.2541915476322174,
-0.04417188838124275,
0.8103278875350952,
-0.21181392669677734,
-0.39015811681747437,
0.36769333481788635,
0.027538718655705452,
-0.009078356437385082,
-0.08079475909471512,
0.4485905170440674,
0.6728391051292419,
-0.3423815667629242,
0.027524683624505997,
0.007123069372028112,
0.3958084285259247,
0.2838396728038788,
-0.10932974517345428,
-0.34561753273010254,
-0.04617413878440857,
-0.01793394796550274,
0.4426877498626709,
-0.5610736012458801,
0.14470453560352325,
0.5957456231117249,
-0.021695533767342567,
0.37857985496520996,
0.35226473212242126,
-0.39011284708976746,
0.8909117579460144,
-0.15778447687625885,
0.14821840822696686,
0.08547919988632202,
0.5188146233558655,
-0.6397720575332642,
-0.2797134816646576,
0.18024250864982605,
0.09993454813957214,
-0.06866110116243362,
-0.17108213901519775,
0.3491820693016052,
0.19894210994243622,
1.1548538208007812,
-0.1319311112165451,
0.2205781489610672,
-0.6674709320068359,
-0.3108835220336914,
0.009906688705086708,
0.16928532719612122,
-0.8654264807701111,
-0.31449225544929504,
0.392844021320343,
0.5262407660484314,
-0.02463456615805626,
-0.006407381035387516,
0.21734263002872467,
0.03856449946761131,
-0.22371040284633636,
-0.09134574234485626,
0.017139185220003128,
-0.23594488203525543,
-0.07803773880004883,
-0.04208860546350479,
0.2742462158203125,
-0.13259302079677582,
0.05860137566924095,
-0.3212158977985382,
-0.7172051668167114,
-0.41257184743881226,
0.5560956597328186,
0.6288551092147827,
0.7374613285064697,
0.16918274760246277,
-0.8397870659828186,
0.055920396000146866,
-0.12737667560577393,
0.0276040006428957,
-0.18265946209430695,
0.289664089679718,
-0.40818580985069275,
0.03911834955215454,
-0.4564362168312073,
0.27558672428131104,
0.8610599637031555,
-0.3855739235877991,
-0.5136268138885498,
0.10599343478679657,
0.08317013084888458,
-0.48433414101600647,
-0.4197143316268921,
-0.3501622974872589,
-0.30077365040779114,
0.4126916825771332,
-0.01929595321416855,
-0.01577473059296608,
0.028017845004796982,
0.021310266107320786,
0.08217820525169373,
0.7844187021255493,
0.9605672955513,
0.02500900998711586,
0.04850942641496658,
-0.03561541810631752,
-0.18704818189144135,
-0.11532142013311386,
0.20845404267311096,
0.017799340188503265,
-0.3891145884990692,
0.19685201346874237,
-5.866654872894287,
-0.1549500823020935,
-0.20199380815029144,
-0.5980685353279114,
0.16359998285770416,
-0.10007110983133316,
0.8065953850746155,
0.12293897569179535,
0.3498516380786896,
0.14162284135818481,
0.5274747014045715,
0.48057863116264343,
-0.07343501597642899,
-0.3575807809829712,
-0.22238928079605103,
-0.3589232265949249,
-0.46439284086227417,
-0.37711650133132935,
0.17552794516086578,
-0.282818466424942,
0.2909241318702698,
-0.1993488371372223,
-0.3635912537574768,
0.7274180054664612,
-0.03526365011930466,
0.4635826051235199,
-0.5324703454971313,
0.17760641872882843,
-0.08694738894701004,
0.35757389664649963,
0.18942499160766602,
-0.60161954164505,
-0.03895797207951546,
-0.09016437828540802,
0.06943047791719437,
0.5429367423057556,
0.27957883477211,
-0.2997545599937439,
-0.2990429997444153,
-0.008855635300278664,
0.3111225962638855,
-0.1640610247850418,
-0.3758845329284668,
-0.09136877208948135,
-0.20082713663578033,
-0.2646632790565491,
-0.21746835112571716,
0.3743404150009155,
0.10096211731433868,
0.5906649827957153,
-0.06831780821084976,
-0.07310061156749725,
0.1155596598982811,
0.6916112899780273,
0.6126000285148621,
0.3056967556476593,
-0.49720922112464905,
-0.06646254658699036,
-0.28719544410705566,
0.08880555629730225,
-0.39616021513938904,
-0.2521175146102905,
-0.24181757867336273,
-0.38129061460494995,
0.13237497210502625,
0.23686955869197845,
-0.44272559881210327,
-0.08514952659606934,
0.5276120901107788,
-0.12476083636283875,
-0.08434990793466568,
0.00269578886218369,
0.35760924220085144,
-0.9605770111083984,
0.7707470059394836,
-0.3235021233558655,
-0.09564004838466644,
-0.2169763296842575,
-0.1020752340555191,
-0.1530209481716156,
-0.4774281978607178,
-0.1655169129371643,
-0.26745301485061646,
-0.27485984563827515,
0.020758314058184624,
-0.6976799368858337,
-0.04796824976801872,
-0.12589092552661896,
-0.013376276940107346,
-0.24548472464084625,
0.4804050624370575,
-0.8519436120986938,
0.23662447929382324,
0.24035541713237762,
0.025385070592164993,
1.2277859449386597,
-0.06711454689502716,
0.7031006217002869,
0.2519366443157196,
0.47720009088516235,
1.0704991817474365,
-0.5212231874465942,
-0.32391759753227234,
-0.9374492168426514,
-0.1587453931570053,
0.1809491366147995,
-0.5940592885017395,
-0.1302613466978073,
0.48016491532325745,
-0.6668384671211243,
0.3235252797603607,
-0.06376680731773376,
-0.6204672455787659,
-0.19249282777309418,
0.859147846698761,
-0.23827022314071655,
0.13160650432109833,
0.4376000761985779,
0.5032086968421936,
0.06878846883773804,
0.37540867924690247,
-0.031795065850019455,
-0.4821789264678955,
0.08093525469303131,
-0.029321763664484024,
0.29988330602645874,
0.31163981556892395,
0.25553712248802185,
-0.3638724982738495,
-0.24676422774791718,
0.36983034014701843,
0.10215075314044952,
-0.26302051544189453,
0.18666605651378632,
0.2522001266479492,
-0.1587475687265396,
-0.2782500684261322,
0.0650537982583046,
-0.01653643138706684,
-0.6673227548599243,
0.2777196764945984,
-0.2593472898006439,
-0.4482947885990143,
-0.0309385247528553,
-0.2899780571460724,
0.033045005053281784,
0.05254131555557251,
-0.0021007449831813574,
-0.10753442347049713,
-0.45345693826675415,
0.20001403987407684,
0.018406584858894348,
0.29360368847846985,
0.37862521409988403,
-1.1569112539291382,
0.22831767797470093,
0.6116311550140381,
0.18208162486553192,
-0.015367142856121063,
-0.8396185636520386,
-0.4363759458065033,
-0.1395023614168167,
-1.1762622594833374,
0.33095577359199524,
-0.35611066222190857,
-0.16217392683029175,
0.28734326362609863,
-0.5018102526664734,
0.161221444606781,
0.3977651596069336,
-0.2877644896507263,
-0.387682169675827,
0.4767994284629822,
0.26719915866851807,
-0.05894851312041283,
-0.28458893299102783,
-0.51055508852005,
-0.5610796809196472,
-0.05958406999707222,
0.41780978441238403,
0.12049981951713562,
-0.06676538288593292,
-0.08724219352006912,
0.6325462460517883,
0.5502614378929138,
0.02868477627635002,
0.28321102261543274,
-0.23835080862045288,
-0.3778464198112488,
-0.1846601963043213,
0.37271007895469666,
0.32145801186561584,
0.41859349608421326,
-0.16900569200515747,
-0.3027871251106262,
0.20460304617881775,
-0.6109064817428589,
0.24677860736846924,
0.29913759231567383,
-0.061877667903900146,
0.04532688483595848,
0.2046145647764206,
-0.25463300943374634,
0.06299610435962677,
0.2862531542778015,
-0.26830485463142395,
-0.01374487578868866,
-0.3284948766231537,
-0.12860402464866638,
-0.30835238099098206,
-0.1824788898229599,
-0.7128711938858032,
0.333565890789032,
0.8009195327758789,
0.021091250702738762,
-0.08070588856935501,
-0.258597195148468,
-0.33342182636260986,
-0.17403320968151093,
0.17942418158054352,
-0.05074148252606392,
-0.4196113348007202,
-0.3632889688014984,
-0.18406526744365692,
-0.34493789076805115,
0.18601590394973755,
0.5848603844642639,
-1.2401965856552124,
0.6031762957572937,
0.23234543204307556,
0.49168235063552856,
-0.2632863521575928,
0.2402568906545639,
0.298209011554718,
-0.30670037865638733,
-0.28101542592048645,
0.22960539162158966,
-0.05103455111384392,
-0.33081695437431335,
0.24789689481258392,
0.32890474796295166,
0.06840121746063232,
-0.21405331790447235,
0.024918312206864357,
0.015582206659018993,
-0.052838969975709915,
0.06558645516633987,
-1.2133758068084717,
-0.05485054850578308,
0.6521021723747253,
0.007738903164863586,
0.19101582467556,
0.14506317675113678,
0.4266996383666992,
0.4894116222858429,
-0.11924079805612564,
0.21307115256786346,
-0.484684020280838,
-0.04532039910554886,
0.011546260677278042,
-0.3091725707054138,
-0.09989477694034576,
-0.3538351058959961,
0.17070885002613068,
0.027318354696035385,
-0.17821304500102997,
-0.018605966120958328,
-0.6315799355506897,
0.3622603416442871,
0.8291107416152954,
0.1474114954471588,
-0.05327221751213074,
0.8734761476516724,
0.18731887638568878,
-0.37445932626724243,
0.2673128843307495,
-0.47771191596984863,
-0.11320065706968307,
-0.5159461498260498,
0.6943116188049316,
-0.18155647814273834,
-0.9728602766990662,
0.2891806364059448,
-0.34935078024864197,
0.24333152174949646,
-0.5037221908569336,
0.3732261061668396,
-0.4409339725971222,
-0.3694871664047241,
-0.10406238585710526,
0.10699120908975601,
0.06665375083684921,
-0.7739738821983337,
-0.5456712245941162,
0.26918986439704895,
0.2774587571620941,
-0.2931056320667267,
0.23654934763908386,
-0.15148437023162842,
-0.2990025579929352,
-0.824016273021698,
0.45628949999809265,
0.207048699259758,
-0.5550374388694763,
0.2533704340457916,
-0.2579623758792877,
0.1850232183933258,
0.13130688667297363,
-0.28040236234664917,
0.10837877541780472,
0.44667091965675354,
0.008012636564671993,
0.3034901022911072,
0.3473203480243683,
-0.18196389079093933,
0.39202603697776794,
-0.601694643497467,
-0.18644730746746063,
0.17224650084972382,
0.26183363795280457,
0.7652688026428223,
0.7716278433799744,
0.35373222827911377,
-0.24623212218284607,
-0.1594492793083191,
0.5948312282562256,
0.2030850499868393,
0.5216684937477112,
0.47650420665740967,
0.6380245089530945,
0.7368284463882446,
-0.20406191051006317,
0.0604131855070591,
0.2756098806858063,
0.9325940608978271,
-0.05628671869635582,
-0.017391791567206383,
-0.43237602710723877,
-0.14292116463184357,
0.01991087757050991,
0.6710941195487976,
-0.03325972333550453,
-0.1668202131986618,
-0.011983410455286503,
-0.17443327605724335,
0.32972201704978943,
-0.05316684767603874,
0.22309274971485138,
0.15041767060756683,
-0.08924024552106857,
0.473405659198761,
-0.4891899526119232,
0.011699202470481396,
0.5196087956428528,
-0.31853461265563965,
-0.21963101625442505,
0.2828036844730377,
-0.4539240598678589,
-0.78554767370224,
0.08929021656513214,
0.14399871230125427,
-0.04968739673495293,
0.032271381467580795,
0.32630303502082825,
0.5396764278411865,
-0.10209968686103821,
0.08047585934400558,
-0.06150626018643379,
0.13374869525432587,
-0.49307793378829956,
0.30038899183273315,
-0.45246320962905884,
0.023700056597590446,
0.5316235423088074,
0.44545412063598633,
0.2571451961994171,
0.4992216229438782,
-0.2569056451320648,
-0.20098532736301422,
0.30953449010849,
-0.6093482971191406,
-0.3377639949321747,
-0.18080772459506989,
-0.41516566276550293,
-0.28068214654922485,
-0.2409624457359314,
0.08695147186517715,
-0.2812815010547638,
-0.049908459186553955,
-0.32880836725234985,
0.22294537723064423,
-0.3473230004310608,
0.3376956284046173,
0.4068150222301483,
0.37282097339630127,
-0.5629109740257263,
0.4737982749938965,
-0.09184878319501877,
0.05318808555603027,
0.6451378464698792,
0.2580769956111908,
0.06425327807664871,
0.04032158479094505,
-0.04282337799668312,
-1.153123140335083,
0.5002343654632568,
-0.11923103034496307,
0.3458895981311798,
-0.9051246643066406,
-0.04107197746634483,
0.5526203513145447,
0.525962233543396,
-0.056246861815452576,
-0.030609210953116417,
0.36532294750213623,
0.2774876058101654,
0.2856580913066864,
-0.6649720668792725,
-0.38471633195877075,
-0.43979689478874207,
0.21248465776443481,
-0.8558140993118286,
0.5556442141532898,
0.22744770348072052,
-0.18765537440776825,
-0.21185718476772308,
0.32982537150382996,
0.26949167251586914,
-0.42310234904289246,
0.4674871563911438,
-0.2701705992221832,
0.33813926577568054,
-0.004990489222109318,
-0.14916051924228668,
-0.4457853436470032,
0.09415066242218018,
0.2267572432756424,
-0.34654104709625244,
0.04347485676407814,
0.06410561501979828,
0.5076548457145691,
-0.7442833185195923,
-0.3493891954421997,
0.0815606415271759,
0.19708339869976044,
-0.15525926649570465,
0.03162313252687454,
-0.6533995270729065,
-0.5424363017082214,
-0.3834898769855499,
-0.12677453458309174,
0.20004531741142273,
-0.04753856360912323,
0.2448330521583557,
0.13097460567951202,
0.4141766130924225,
0.10795506834983826,
-0.34811246395111084,
-0.47558510303497314,
0.17032374441623688
] |
Peptidases are enzymes that hydrolyse peptide bonds in proteins and peptides. Peptidases are important in pathological conditions such as Alzheimer's disease, tumour and parasite invasion, and for processing viral polyproteins. The MEROPS database is an Internet resource containing information on peptidases, their substrates and inhibitors. The database now includes details of cleavage positions in substrates, both physiological and non-physiological, natural and synthetic. There are 39 118 cleavages in the collection; including 34 606 from a total of 10 513 different proteins and 2677 cleavages in synthetic substrates. The number of cleavages designated as ‘physiological’ is 13 307. The data are derived from 6095 publications. At least one substrate cleavage is known for 45% of the 2415 different peptidases recognized in the MEROPS database. The website now has three new displays: two showing peptidase specificity as a logo and a frequency matrix, the third showing a dynamically generated alignment between each protein substrate and its most closely related homologues. Many of the proteins described in the literature as peptidase substrates have been studied only in vitro. On the assumption that a physiologically relevant cleavage site would be conserved between species, the conservation of every site in terms of peptidase preference has been examined and a number have been identified that are not conserved. There are a number of cogent reasons why a site might not be conserved. Each poorly conserved site has been examined and a reason postulated. Some sites are identified that are very poorly conserved where cleavage is more likely to be fortuitous than of physiological relevance. This data-set is freely available via the Internet and is a useful training set for algorithms to predict substrates for peptidases and cleavage positions within those substrates. The data may also be useful for the design of inhibitors and for engineering novel specificities into peptidases. Database URL: http://merops.sanger.ac.uk | [
-0.009238756261765957,
-0.004673046991229057,
-0.001223093713633716,
0.020678158849477768,
0.008386945351958275,
0.027109477669000626,
0.010432535782456398,
0.003940929658710957,
-0.009558971971273422,
0.029029617086052895,
-0.003939093090593815,
0.001668370678089559,
-0.01233251765370369,
0.010623912326991558,
0.011626528576016426,
0.022070780396461487,
-0.01767415553331375,
-0.01933705434203148,
0.005509200505912304,
0.003871105145663023,
-0.010271364822983742,
0.007016968913376331,
0.008998287841677666,
-0.03685293719172478,
-0.025364316999912262,
-0.017018094658851624,
0.0391535684466362,
-0.04209998995065689,
0.008290950208902359,
-0.00864448957145214,
0.020767997950315475,
-0.009582534432411194,
0.0037509091198444366,
-0.04146849736571312,
0.0068565900437533855,
0.01853374019265175,
-0.010164459235966206,
0.014926902018487453,
0.034241579473018646,
-0.00481974333524704,
-0.019379137083888054,
-0.00967815238982439,
0.007607321720570326,
-0.030276071280241013,
-0.00875452533364296,
-0.013371910899877548,
0.000035014585591852665,
0.005403145682066679,
-0.011446623131632805,
0.0015031432267278433,
-0.012524841353297234,
0.001493167714215815,
-0.0034440457820892334,
-0.0004916167818009853,
-0.005867289379239082,
-0.006202579475939274,
0.01727084442973137,
-0.015329031273722649,
-0.004977189004421234,
-0.0046471646055579185,
-0.0008967679459601641,
0.007411657832562923,
-0.002123367041349411,
0.018515128642320633,
-0.021552076563239098,
-0.06725312769412994,
0.013918320648372173,
-0.0006847023032605648,
-0.005216538906097412,
0.007597500458359718,
0.01447191834449768,
0.005049734376370907,
-0.010657965205609798,
0.0027751836460083723,
0.015559380874037743,
-0.0055994801223278046,
-0.0027276084292680025,
0.020862281322479248,
0.023766562342643738,
0.015657812356948853,
-0.007980410009622574,
-0.005640816409140825,
0.012838202528655529,
0.012737632729113102,
0.003271158318966627,
0.005800948943942785,
-0.025285780429840088,
0.011139128357172012,
-0.012342861853539944,
0.011115746572613716,
0.004791851621121168,
0.013708625920116901,
-0.04265168309211731,
0.011712482199072838,
0.016443759202957153,
-0.0020642969757318497,
-0.01047070324420929,
-0.004980168305337429,
0.003010672517120838,
0.02521004155278206,
-0.020303040742874146,
0.029375841841101646,
0.01498435065150261,
0.014969419687986374,
-0.005684025585651398,
0.006880328059196472,
0.009956588968634605,
0.021145036444067955,
0.014264790341258049,
0.011500321328639984,
-0.008370941504836082,
-0.007542487233877182,
-0.04166223108768463,
-0.020992357283830643,
0.033650241792201996,
0.02941788174211979,
-0.002882598200812936,
-0.006253805011510849,
0.013229560106992722,
-0.005266495514661074,
0.006453763693571091,
0.022902481257915497,
0.005639935377985239,
0.02742396667599678,
0.008195675909519196,
0.000019336584955453873,
0.014940617606043816,
0.01117678638547659,
0.01565181277692318,
-0.005492602474987507,
-0.00885828398168087,
0.0019085431704297662,
-0.014351553283631802,
0.01627061516046524,
0.014222797937691212,
-0.005237090401351452,
0.013845589011907578,
-0.0212269127368927,
0.0080632995814085,
-0.011420794762670994,
0.012561994604766369,
0.008220074698328972,
0.020395219326019287,
0.019814468920230865,
-0.007148228585720062,
-0.00038858375046402216,
0.008446432650089264,
-0.01213025487959385,
0.0033544013276696205,
0.014902672730386257,
0.0080764414742589,
-0.0012946452479809523,
-0.03570498526096344,
-0.018803836777806282,
0.012908227741718292,
-0.01105902437120676,
0.0023902254179120064,
-0.032357580959796906,
0.002949960995465517,
-0.00395757332444191,
-0.02849949151277542,
0.024726606905460358,
0.008442278951406479,
0.008156734518706799,
-0.02644096314907074,
-0.012086920440196991,
0.0018583107739686966,
-0.018367715179920197,
0.013036438263952732,
0.007778894156217575,
-0.008459320291876793,
0.0010744594037532806,
0.010891606099903584,
0.0033385176211595535,
0.0006234673783183098,
0.005932403728365898,
-0.0022190790623426437,
0.0064386967569589615,
-0.020076485350728035,
0.06729865074157715,
-0.006574916187673807,
0.025161370635032654,
-0.03194846957921982,
0.006537845823913813,
0.0031248880550265312,
-0.007266853004693985,
0.028823047876358032,
-0.019386358559131622,
0.018885362893342972,
-0.016254819929599762,
-0.0327279269695282,
-0.010548992082476616,
0.02316303737461567,
0.014616585336625576,
-0.0009360455442219973,
0.0027919872663915157,
-0.00957810040563345,
0.01945786364376545,
-0.015598309226334095,
-0.000812591752037406,
-0.013912900350987911,
0.0025549926795065403,
-0.007678307592868805,
0.028120920062065125,
0.016990669071674347,
0.016045954078435898,
-0.0003132089041173458,
0.003603744087740779,
0.0019571809098124504,
0.027367956936359406,
0.033039700239896774,
0.0024415147490799427,
0.024031605571508408,
-0.008503544144332409,
-0.012025024741888046,
-0.0009801615960896015,
-0.014919452369213104,
-0.032645322382450104,
0.0014507295563817024,
-0.011227170936763287,
-0.006128036417067051,
-0.00862063281238079,
-0.0048135314136743546,
0.011926110833883286,
-0.006311532109975815,
0.00228870939463377,
0.0029914663173258305,
0.012814987450838089,
-0.013713400810956955,
0.020881900563836098,
0.01078330259770155,
0.004828049335628748,
-0.011903852224349976,
0.007855065166950226,
0.012388888746500015,
0.004872919525951147,
0.01007835753262043,
-0.006030450575053692,
0.015472810715436935,
-0.0027385845314711332,
-0.014335742220282555,
-0.006077502854168415,
-0.003089744132012129,
-0.026717308908700943,
0.029006917029619217,
0.0041418662294745445,
-0.007321896497160196,
0.011050784960389137,
0.013815986923873425,
-0.0051334323361516,
0.007416943088173866,
0.025655275210738182,
0.008931228891015053,
0.0010443076025694609,
-0.03630635514855385,
-0.0027948955539613962,
-0.020561495795845985,
-0.039445504546165466,
0.02235555648803711,
-0.0025429746601730585,
0.006712658330798149,
0.013088971376419067,
-0.0065886047668755054,
0.013652236200869083,
0.009990120306611061,
0.012605836614966393,
0.0060383351519703865,
0.0008940636180341244,
0.0033389264717698097,
0.011675931513309479,
0.00278536812402308,
-0.007065529469400644,
-0.0027502134907990694,
-0.0815279483795166,
-0.0037772683426737785,
-0.009582914412021637,
-0.0013578872894868255,
0.0076983049511909485,
0.02036273665726185,
-0.002473644446581602,
-0.002122187986969948,
0.005751441232860088,
-0.01359297800809145,
0.03242376074194908,
0.013877899385988712,
-0.008231217972934246,
0.008051255717873573,
0.005059412680566311,
0.000934144773054868,
0.011334528215229511,
-0.01533784344792366,
0.004619107581675053,
-0.006724338047206402,
-0.014127764850854874,
0.009455453604459763,
-0.021149618551135063,
-0.004476246424019337,
-0.013643836602568626,
-0.010323463007807732,
0.023086300119757652,
-0.006434379145503044,
-0.016162443906068802,
0.007157624699175358,
-0.024083655327558517,
-0.021857570856809616,
-0.014986317604780197,
-0.021471641957759857,
0.0030640363693237305,
0.0034558596089482307,
-0.0022130156867206097,
0.003668739227578044,
-0.0010574194602668285,
0.03950897231698036,
-0.018570564687252045,
0.016105864197015762,
-0.0027240023482590914,
0.0032182345166802406,
-0.006376227363944054,
-0.002413408365100622,
0.012401342391967773,
-0.005601802840828896,
0.005586730316281319,
-0.016547372564673424,
0.0033460110425949097,
0.005868361797183752,
-0.0027050161734223366,
0.015638727694749832,
-0.014437882229685783,
0.019298620522022247,
-0.0020991736091673374,
0.00231117382645607,
-0.016215268522500992,
-0.012077105231583118,
-0.04905100166797638,
0.02352316863834858,
0.009619185701012611,
0.03426720201969147,
-0.015798434615135193,
0.012960018590092659,
0.014380100183188915,
-0.011140971444547176,
-0.00569490622729063,
0.005785250570625067,
0.008708233013749123,
0.01065088715404272,
-0.01703331060707569,
-0.0009408689802512527,
0.012766705825924873,
-0.01298165787011385,
-0.015263033099472523,
-0.0092723798006773,
-0.015397598966956139,
-0.020390139892697334,
-0.020892491564154625,
0.015614423900842667,
-0.02812199667096138,
-0.009133057668805122,
-0.009963778778910637,
0.007075062021613121,
0.00759880430996418,
-0.003737138118594885,
0.003979844972491264,
-0.009093629196286201,
0.01522841677069664,
-0.0066094594076275826,
-0.006400271784514189,
0.009625712409615517,
-0.024490274488925934,
-0.025184793397784233,
0.010797377675771713,
-0.01172573771327734,
0.0022956309840083122,
0.006729261949658394,
0.004927515052258968,
0.003663827432319522,
-0.010277152061462402,
-0.013837713748216629,
0.02158357948064804,
0.014106867834925652,
-0.0037213540636003017,
0.02608593739569187,
0.00410250062122941,
0.002245166804641485,
-0.03115374967455864,
-0.02995532937347889,
-0.005289311520755291,
-0.006415166426450014,
0.006941024214029312,
0.006656232289969921,
-0.012050732970237732,
-0.0012114711571484804,
0.07224253565073013,
0.018171366304159164,
-0.006438985466957092,
-0.0215916745364666,
0.010084375739097595,
-0.025787148624658585,
0.008657345548272133,
0.013362998142838478,
0.00011750776320695877,
-0.00041637104004621506,
0.010901980102062225,
0.0017715534195303917,
0.014637796208262444,
-0.03182031214237213,
-0.021545980125665665,
-0.016576029360294342,
-0.0036479479167610407,
-0.010835686698555946,
-0.0007428291719406843,
0.019848186522722244,
-0.0006152957212179899,
-0.004036519676446915,
-0.016922317445278168,
-0.0157892107963562,
-0.03557461500167847,
-0.011896735988557339,
-0.012372138909995556,
-0.013673502951860428,
-0.005587738007307053,
0.010097785852849483,
0.009980170987546444,
0.013162602670490742,
-0.013187754899263382,
-0.0005828859284520149,
-0.022208252921700478,
-0.0007227146998047829,
0.02512083202600479,
-0.012487889267504215,
0.006155489943921566,
-0.0007196478545665741,
-0.01291193813085556,
-0.016719821840524673,
-0.009932677261531353,
0.02122008427977562,
-0.010631486773490906,
0.021367017179727554,
0.0013200757093727589,
-0.01223367266356945,
0.002742888405919075,
-0.024748187512159348,
-0.000812973827123642,
0.029824156314134598,
0.00718828896060586,
-0.007183157838881016,
0.00043877121061086655,
0.009914139285683632,
0.00826417375355959,
-0.010787710547447205,
-0.02695368230342865,
0.01663699373602867,
0.006721151061356068,
0.010207662358880043,
-0.033452268689870834,
-0.005948246456682682,
0.00745036406442523,
-0.009180313907563686,
-0.004731964319944382,
0.007503417320549488,
0.015864575281739235,
0.023218927904963493,
0.024295490235090256,
-0.0018555670976638794,
-0.0065408325754106045,
-0.004186620935797691,
-0.01687232404947281,
-0.0009716714266687632,
-0.018063630908727646,
0.003996059764176607,
0.02147107571363449,
0.02818838320672512,
-0.017501287162303925,
0.010839013382792473,
0.006253029219806194,
-0.025508500635623932,
-0.007439458277076483,
0.01583760417997837,
-0.010928256437182426,
-0.07423660159111023,
-0.008380115032196045,
-0.023919416591525078,
-0.0018589117098599672,
-0.01204768568277359,
-0.0036394186317920685,
-0.01771668717265129,
-0.004722382873296738,
0.03194168210029602,
-0.010976172983646393,
0.011762240901589394,
-0.007206029258668423,
0.01910150796175003,
0.006610742770135403,
0.0105905057862401,
-0.00011539226397871971,
-0.011809860356152058,
0.013691614381968975,
-0.00012307800352573395,
-0.010261754505336285,
-0.0011378938797861338,
-0.00043056439608335495,
-0.03257269039750099,
0.0060877311043441296,
-0.02158813364803791,
-0.08097733557224274,
-0.026692479848861694,
0.018210720270872116,
0.004853994585573673,
-0.008821515366435051,
0.015396569855511189,
0.010357243940234184,
-0.013388561084866524,
-0.017137661576271057,
-0.01454542763531208,
-0.002304558642208576,
-0.0062821717001497746,
-0.011911648325622082,
-0.01572321727871895,
0.00889513548463583,
-0.010895447805523872,
0.006023172754794359,
-0.002860447857528925,
-0.01755785197019577,
-0.007926109246909618,
-0.01032429188489914,
0.02279951423406601,
-0.012198230251669884,
0.0028135713655501604,
-0.00884668156504631,
-0.0055516683496534824,
-0.029509287327528,
0.010726867243647575,
0.0216723270714283,
-0.004412977024912834,
-0.02457601949572563,
-0.0012752339243888855,
0.009552035480737686,
-0.00855652429163456,
0.0049914163537323475,
-0.01697532832622528,
0.0018109085503965616,
0.01869773305952549,
0.035310566425323486,
-0.023670630529522896,
-0.013755914755165577,
-0.0004443360958248377,
-0.024671602994203568,
0.004549876786768436,
-0.0020277746953070164,
0.013628519140183926,
0.007952499203383923,
-0.006620931439101696,
0.004383954685181379,
0.02464483492076397,
0.009089001454412937,
0.02476145327091217,
0.024609558284282684,
-0.002331233350560069,
0.0034962850622832775,
-0.0037835349794477224,
0.0020442542154341936,
0.002589465118944645,
-0.011798178777098656,
0.017904650419950485,
-0.005097928456962109,
0.00842706672847271,
0.014168085530400276,
0.07248975336551666,
-0.004802508279681206,
0.0073321666568517685,
-0.008680123835802078,
0.006779252085834742,
0.008393931202590466,
0.02050694264471531,
-0.019423555582761765,
0.018548952415585518,
-0.006999894045293331,
-0.004529787227511406,
-0.02008889988064766,
0.019373245537281036,
0.014196328818798065,
-0.012675106525421143,
-0.0054330467246472836,
-0.020653415471315384,
-0.0028038383461534977,
-0.004496589303016663,
0.04388115182518959,
-0.017010614275932312,
0.018262287601828575,
-0.02887856215238571,
-0.01113562099635601,
0.00564740551635623,
-0.013592188246548176,
-0.015919238328933716,
-0.0009625502862036228,
0.012621913105249405,
-0.0019551473669707775,
0.004328321665525436,
0.004795514978468418,
0.0016298247501254082,
0.005452427081763744,
0.023813607171177864,
0.008349725976586342,
0.006241893395781517,
0.0009426119504496455,
-0.008353283628821373,
-0.017945200204849243,
-0.032266244292259216,
0.016201339662075043,
0.011864183470606804,
0.006512175779789686,
0.01605483889579773,
0.026341184973716736,
0.008102662861347198,
-0.010210086591541767,
-0.011276925913989544,
-0.004281594417989254,
-0.020059820264577866,
0.006623431108891964,
0.04592329263687134,
-0.00837359856814146,
0.005321766249835491,
0.0060350531712174416,
-0.02487896755337715,
0.009426286444067955,
-0.02420930750668049,
0.007061081938445568,
0.002092450624331832,
-0.00545153021812439,
-0.012281226925551891,
-0.010950809344649315,
0.021601321175694466,
0.00781499594449997,
-0.0044474415481090546,
-0.013705126941204071,
0.016494039446115494,
0.015589885413646698,
-0.01571435108780861,
0.005006187595427036,
0.007342826575040817,
0.00441548740491271,
0.0011833726894110441,
0.0167088583111763,
0.028034109622240067,
-0.015253080986440182,
0.028103193268179893,
0.003300915937870741,
-0.009353923611342907,
-0.024497542530298233,
0.03646114468574524,
0.007296094670891762,
-0.015057080425322056,
0.002887370064854622,
0.013777509331703186,
0.00807812251150608,
-0.0005594163085334003,
0.012586427852511406,
0.01092702616006136,
0.00008618185529485345,
0.002575524151325226,
0.022638022899627686,
0.0069100819528102875,
0.03330413997173309,
0.006517693866044283,
0.008492279797792435,
-0.006431094370782375,
0.02224905602633953,
0.005270691588521004,
-0.005116218701004982,
-0.02478264644742012,
-0.0031380276195704937,
-0.004350689705461264,
0.0104288998991251,
-0.0014871926978230476,
-0.01856875792145729,
0.04228551313281059,
0.009554009884595871,
-0.014044110663235188,
-0.016698405146598816,
-0.0011185682378709316,
0.0057398187927901745,
-0.001301365438848734,
0.029307454824447632,
-0.015796029940247536,
0.020581405609846115,
-0.01385505311191082,
-0.009243035688996315,
-0.011027281172573566,
0.015843817964196205,
-0.02467247284948826,
-0.025150345638394356,
0.01498464122414589,
-0.006723578087985516,
-0.010330252349376678,
-0.005880375392735004,
-0.0009408807381987572,
0.0118829645216465,
0.025935042649507523,
-0.04049225151538849,
0.0017208864446729422,
0.005857323296368122,
-0.019205402582883835,
-0.012807166203856468,
-0.0007192213088274002,
-0.011828165501356125,
0.002530791098251939,
-0.005539931356906891,
0.003698950633406639,
-0.03040120378136635,
0.004115433897823095,
0.02991822548210621,
0.00848010927438736,
0.013298256322741508,
0.011260796338319778,
-0.00818321667611599,
0.011551082134246826,
0.017899487167596817,
0.026096919551491737,
0.006280737929046154,
0.002061131875962019,
-0.006118846591562033,
-0.039718128740787506,
0.018603544682264328,
0.013203110545873642,
-0.004638518672436476,
0.0016414036508649588,
0.013799598440527916,
0.0207513440400362,
0.040542855858802795,
-0.015162528492510319,
0.001992806326597929,
0.03126737102866173,
-0.04111604765057564,
0.01610189490020275,
-0.002844333415850997,
0.0036661550402641296,
0.003587812650948763,
0.01980876922607422,
0.0004763741744682193,
-0.021485133096575737,
0.00893919263035059,
0.008323567919433117,
-0.02073807269334793,
-0.01112968847155571,
0.011818812228739262,
0.008058395236730576,
0.017188027501106262,
0.008063376881182194,
0.009859154000878334,
0.0027870377525687218,
-0.009393077343702316,
-0.010510841384530067,
0.009201189503073692,
-0.006024508737027645,
-0.01491621509194374,
0.0031255176290869713,
0.0274442657828331,
-0.005289819557219744,
-0.002955069998279214,
0.0007304376922547817,
-0.001205196836963296,
0.002361598424613476,
-0.013280023820698261,
0.0052946023643016815,
-0.04870014265179634,
0.02123451419174671,
0.010429133661091328,
0.015930810943245888,
-0.017510397359728813
] | [
0.4011410176753998,
0.048019491136074066,
0.22567056119441986,
-0.18849791586399078,
-0.05256665125489235,
0.5671903491020203,
0.07544264197349548,
-0.23624692857265472,
-0.2945619821548462,
-0.5559186339378357,
0.10870491713285446,
-0.034091074019670486,
-0.6369571089744568,
0.6015623807907104,
0.04999355599284172,
0.6567487120628357,
0.06746787577867508,
0.7485780715942383,
0.3677566349506378,
-0.6709697246551514,
-0.40207788348197937,
0.13020725548267365,
0.607055127620697,
-0.31507283449172974,
0.23825012147426605,
0.5407568216323853,
0.12890544533729553,
-0.20200861990451813,
-0.1827774941921234,
0.20319409668445587,
-0.1091461181640625,
0.15536092221736908,
0.3573402464389801,
0.24497361481189728,
-0.21737442910671234,
-0.13372068107128143,
-0.637412428855896,
-0.005805759225040674,
0.2641463279724121,
-0.01050486695021391,
-0.6642093658447266,
-0.37544071674346924,
-0.26462307572364807,
0.5878591537475586,
-0.22772909700870514,
0.3533315360546112,
-1.1635215282440186,
0.5728273987770081,
-0.19373595714569092,
0.15952804684638977,
0.029665138572454453,
0.04747449979186058,
0.5532244443893433,
0.34067222476005554,
0.34557676315307617,
-0.05173136666417122,
-0.591827929019928,
0.20991429686546326,
0.2440008819103241,
-0.20539522171020508,
0.24269232153892517,
0.3858167827129364,
-0.04373675584793091,
0.5498103499412537,
0.07774418592453003,
0.5078141689300537,
0.07277426868677139,
0.23359224200248718,
-0.888273298740387,
-0.07791584730148315,
0.11175540089607239,
-0.05473059043288231,
-0.3180358409881592,
0.6862714886665344,
0.11750635504722595,
-0.728839099407196,
-0.4674187898635864,
0.12619908154010773,
0.7595053911209106,
0.20659145712852478,
0.5526808500289917,
0.538659930229187,
0.131891667842865,
0.01836623251438141,
0.28019875288009644,
0.23030321300029755,
-0.44454777240753174,
0.6563011407852173,
-0.7192685604095459,
-0.10144399106502533,
0.16159702837467194,
-0.29823070764541626,
0.10510089248418808,
-0.15450648963451385,
-0.04888078197836876,
0.3443343937397003,
0.048944827169179916,
0.01757434569299221,
0.12415888905525208,
0.2735416293144226,
-0.06647863239049911,
0.4762367010116577,
-0.10376999527215958,
-0.4326106905937195,
-0.39676156640052795,
-0.004428397864103317,
0.14829160273075104,
-0.7570765614509583,
0.0360177606344223,
0.04696378484368324,
-0.8794762492179871,
-0.07689863443374634,
-0.507858157157898,
-0.11896640062332153,
-0.17358875274658203,
0.37304380536079407,
0.25273266434669495,
0.10129503160715103,
-0.0030776753555983305,
-0.08607812970876694,
-0.5477488040924072,
0.5895556807518005,
0.5208541750907898,
0.06239122897386551,
0.21241044998168945,
0.22925592958927155,
-0.14054132997989655,
-0.18345075845718384,
-0.6102455854415894,
0.5421090126037598,
0.554339587688446,
0.6207801699638367,
-0.15245971083641052,
0.10133590549230576,
-0.016200609505176544,
-0.6482912302017212,
0.2099675089120865,
0.4513605237007141,
0.45039430260658264,
-0.08347834646701813,
-0.89479660987854,
0.11338990926742554,
-0.7917972803115845,
-0.02612881176173687,
0.013658829033374786,
-0.6450124382972717,
-0.17204850912094116,
0.17044396698474884,
-0.5719841718673706,
0.1798047572374344,
0.08978939056396484,
-0.45527318120002747,
-0.13239765167236328,
-0.396917462348938,
-0.20539997518062592,
0.32044994831085205,
0.08891627192497253,
0.18705503642559052,
0.20327480137348175,
-0.3732120096683502,
0.702838659286499,
0.07438456267118454,
-0.6238280534744263,
0.04872060567140579,
0.14454831182956696,
-0.188362717628479,
0.38056671619415283,
0.15233953297138214,
0.16278021037578583,
0.3368392288684845,
-0.19163264334201813,
-0.35238027572631836,
0.2535935938358307,
-0.7454719543457031,
-0.5479599833488464,
0.13205350935459137,
0.5278232097625732,
-0.24822942912578583,
0.32929566502571106,
-0.3626944124698639,
-0.7516767382621765,
-0.34204766154289246,
0.35529279708862305,
-0.5871568918228149,
-0.1612113118171692,
-0.08194762468338013,
1.066572904586792,
-0.1172405555844307,
0.20471563935279846,
0.40185463428497314,
-0.3538931608200073,
-0.7348965406417847,
0.6680833697319031,
-0.6833846569061279,
1.352103352546692,
-0.15312696993350983,
-0.5263303518295288,
0.5156486630439758,
-0.015499641187489033,
-0.5561578273773193,
-0.7450759410858154,
0.25398361682891846,
0.45826390385627747,
-0.8684295415878296,
-0.37428054213523865,
-0.12215331196784973,
-0.10971724987030029,
-0.45174962282180786,
0.18721218407154083,
0.14955590665340424,
0.6124854683876038,
-0.6416352391242981,
0.0818030908703804,
-0.07533052563667297,
-0.07609163969755173,
-0.5944969654083252,
0.2909524440765381,
0.02865319326519966,
0.43345823884010315,
-0.1484600007534027,
0.4980452358722687,
-0.2226538062095642,
0.2703184485435486,
0.44191890954971313,
-0.19185250997543335,
0.5536255240440369,
0.18862618505954742,
0.342970073223114,
0.5058599710464478,
0.45574042201042175,
0.4584228992462158,
-0.12299400568008423,
0.49301251769065857,
-0.089015893638134,
0.07407499849796295,
-0.4166598320007324,
0.30289462208747864,
-0.09574802964925766,
-0.10693122446537018,
-0.6432895660400391,
0.16193640232086182,
0.2965947091579437,
-0.5633288621902466,
-0.5609809756278992,
0.26415789127349854,
-0.6026843190193176,
-0.03575495630502701,
0.33456364274024963,
-0.34661924839019775,
-0.058742623776197433,
-0.4670866131782532,
0.32029321789741516,
0.017505962401628494,
-0.41626548767089844,
-0.04577971622347832,
0.30435478687286377,
0.1663488745689392,
-0.4640800654888153,
-0.2563032805919647,
-0.1367504894733429,
-0.48829367756843567,
-0.6658394932746887,
-0.015564007684588432,
0.5417855381965637,
0.21520258486270905,
-0.15080216526985168,
-0.12084858119487762,
-0.25572440028190613,
1.4088120460510254,
0.5791378021240234,
1.1266484260559082,
0.08876381814479828,
-1.0827373266220093,
-0.12862887978553772,
-0.3479720950126648,
-0.5341035723686218,
-0.007032653316855431,
0.25872257351875305,
-0.32687729597091675,
-0.48000797629356384,
0.15814487636089325,
0.10868751257658005,
0.5578683018684387,
-0.5143290758132935,
-0.1962118148803711,
-0.23156563937664032,
0.1407785266637802,
-0.33123084902763367,
-0.25675538182258606,
0.13748979568481445,
-0.23885375261306763,
0.44350147247314453,
-0.513745129108429,
-0.7776513695716858,
0.1261538416147232,
-0.2536032497882843,
-0.2690860629081726,
0.6086453795433044,
0.8852381110191345,
-0.1724666804075241,
0.20413076877593994,
-0.03265906497836113,
-0.21737158298492432,
-0.36336246132850647,
0.2570382356643677,
0.07019644230604172,
0.27134764194488525,
-0.028121599927544594,
-5.54368257522583,
-0.16246359050273895,
-0.5316288471221924,
-0.3376433551311493,
0.8670899271965027,
-0.07682278007268906,
1.1262054443359375,
-0.025366440415382385,
0.099751316010952,
-0.3680269420146942,
-0.10271533578634262,
-0.011662246659398079,
0.09653917700052261,
0.2319553792476654,
-0.013362230733036995,
0.5768230557441711,
0.7567098736763,
0.1975940763950348,
1.045042634010315,
-0.07226070761680603,
0.2153943032026291,
-0.7076115608215332,
0.14125609397888184,
0.6088736653327942,
-0.1684216856956482,
-0.24818724393844604,
-1.5477383136749268,
0.33507099747657776,
-0.2780119776725769,
-0.3842875361442566,
0.03443291783332825,
-0.43843770027160645,
-0.6978755593299866,
-0.5488549470901489,
0.34668752551078796,
-0.31714123487472534,
-0.1639714390039444,
-0.18929338455200195,
-0.6181755065917969,
-0.23261640965938568,
0.863065779209137,
0.47080957889556885,
0.29413512349128723,
-0.34516441822052,
0.4745819568634033,
-0.06224386394023895,
-0.09030928462743759,
-0.5197940468788147,
-0.06747794151306152,
0.7809890508651733,
-0.05515434220433235,
-0.18592362105846405,
0.5658706426620483,
0.2578265368938446,
0.7747034430503845,
-0.34073060750961304,
-0.12892548739910126,
0.406683087348938,
-0.30048584938049316,
0.25825315713882446,
0.35433870553970337,
-0.21981175243854523,
0.10957929491996765,
-1.145080327987671,
-0.5974321961402893,
0.3545394539833069,
-0.8442838788032532,
-0.5868127942085266,
0.07688669115304947,
-0.005787489470094442,
-0.786988377571106,
0.5383089780807495,
-0.15897706151008606,
-0.794697642326355,
0.7644415497779846,
-0.028297465294599533,
0.3914165198802948,
-0.12279494851827621,
-0.044451192021369934,
0.14576883614063263,
-0.6864058375358582,
0.07199044525623322,
-0.20034991204738617,
-0.11563576012849808,
0.3816264569759369,
-0.6207293272018433,
-0.5251824855804443,
-0.2550775706768036,
-0.022580532357096672,
0.4116871953010559,
0.3694271147251129,
0.016637371852993965,
0.5689873695373535,
0.558606743812561,
0.48225831985473633,
-0.25732409954071045,
-0.22552995383739471,
0.7581737041473389,
0.3577428460121155,
-0.10708342492580414,
0.6870141625404358,
0.14923515915870667,
-0.6948152184486389,
-0.32291722297668457,
0.015224935486912727,
0.005160700064152479,
-0.867798924446106,
-0.21005919575691223,
0.2583552598953247,
-0.5015826225280762,
-0.3504132330417633,
0.0015750592574477196,
-0.31629976630210876,
-0.0442025326192379,
0.717192530632019,
-0.17812089622020721,
-0.07902389019727707,
0.3307918310165405,
0.4558730125427246,
-0.5278654098510742,
-0.19909949600696564,
0.3817996382713318,
-0.5431306958198547,
0.30168354511260986,
-0.03016834333539009,
-0.2835340201854706,
0.27624812722206116,
-0.3881129026412964,
-0.1670440137386322,
0.17260634899139404,
0.439603328704834,
0.5016814470291138,
-0.29286983609199524,
-0.31472867727279663,
0.25199833512306213,
-0.20860227942466736,
-0.15508118271827698,
0.3912869393825531,
-0.09695718437433243,
-0.5519914627075195,
0.18513157963752747,
-0.2810668349266052,
0.1733064502477646,
0.4394855499267578,
0.769733190536499,
0.16841700673103333,
0.2419780045747757,
0.693415105342865,
0.07688146084547043,
0.4064995050430298,
0.36655086278915405,
-0.07882807403802872,
0.08103474974632263,
-0.2659079134464264,
0.08985370397567749,
0.2591698467731476,
0.3345601260662079,
0.6289952397346497,
0.21416078507900238,
-0.5976588129997253,
0.34357011318206787,
-0.27519160509109497,
-0.38582339882850647,
0.01905641332268715,
-0.9240666031837463,
-0.3189208507537842,
0.16977187991142273,
-0.04236584156751633,
-0.6317821145057678,
-0.15196551382541656,
-0.5853870511054993,
-0.32546648383140564,
0.4089208245277405,
0.20734712481498718,
-0.24665164947509766,
-0.14783070981502533,
-0.2282809615135193,
0.3615404963493347,
-0.35035440325737,
-0.06771177798509598,
-0.43318143486976624,
-0.8294177651405334,
0.2424764633178711,
0.18463467061519623,
-0.08507070690393448,
0.12895935773849487,
-0.30798184871673584,
-0.23330016434192657,
-0.25365498661994934,
-0.590610682964325,
-0.059238042682409286,
0.07644066959619522,
0.3567795753479004,
-0.58863365650177,
-0.12763111293315887,
-0.3823465406894684,
0.34353673458099365,
0.5517007112503052,
0.14308391511440277,
-0.6467156410217285,
0.07627294212579727,
0.6627987623214722,
-0.48360034823417664,
0.3316846191883087,
0.5889249444007874,
-0.06492559611797333,
-0.29071521759033203,
0.3937385380268097,
0.22434218227863312,
-0.5478682518005371,
-0.4668356776237488,
-0.6514729261398315,
-0.20478928089141846,
0.059855975210666656,
-0.5186541080474854,
0.35361793637275696,
0.28623148798942566,
-0.2680560350418091,
-0.05501898005604744,
0.12716543674468994,
-0.2888631522655487,
-0.3520416021347046,
-0.11686984449625015,
0.19546866416931152,
-0.32291510701179504,
0.3880196213722229,
0.19401633739471436,
-0.503991425037384,
0.7059710621833801,
-0.42441028356552124,
-0.020923158153891563,
-0.1858789175748825,
0.1527627408504486,
0.098349429666996,
-0.10993142426013947,
-0.6468921899795532,
-0.6408774256706238,
0.08617159724235535,
0.19035105407238007,
0.2858082950115204,
-0.7203609943389893,
0.20278267562389374,
-0.4182271659374237,
-0.23058024048805237,
0.22407446801662445,
0.34746062755584717,
0.5416496396064758,
-0.7341077327728271,
-0.3503071665763855,
0.10600815713405609,
0.08476381748914719,
0.0007104245014488697,
0.18814349174499512,
0.08528178185224533,
1.0301955938339233,
0.631671130657196,
-0.2417251318693161,
-0.3856508135795593,
-0.021453192457556725,
0.05378520116209984,
-0.40786078572273254,
0.4485115110874176,
-0.6623091697692871,
0.28820064663887024,
0.15208010375499725,
-0.43118560314178467,
-0.5473935604095459,
-0.5580830574035645,
0.35760679841041565,
-0.07651219516992569,
-0.20928390324115753,
0.3681398034095764,
0.25927734375,
0.6724855303764343,
-0.0018885061144828796,
0.5266208648681641,
0.42128217220306396,
0.05184650048613548,
0.23623637855052948,
0.035318125039339066,
-0.9025914072990417,
0.02011006884276867,
0.45293286442756653,
-0.13220375776290894,
0.4973830282688141,
-0.689953088760376,
-0.12442541867494583,
-0.42636677622795105,
-0.5363467335700989,
-0.11386322230100632,
0.22426338493824005,
0.5803709030151367,
-0.6100486516952515,
-0.47736310958862305,
-0.30332615971565247,
0.6914222836494446,
0.5477164387702942,
0.07714113593101501,
-0.12132398784160614,
-0.055907733738422394,
-0.08266811072826385,
0.130112886428833,
0.9691267013549805,
-0.7272774577140808,
-0.08843272179365158,
0.39966392517089844,
0.25656411051750183,
-0.503508448600769,
-0.4359535872936249,
0.2832163870334625,
0.28446581959724426,
0.17300711572170258,
0.6222522258758545,
0.00681026978418231,
-0.3962162137031555,
-0.20983079075813293,
-0.26714420318603516,
-0.16250988841056824,
-0.02623707614839077,
0.45182815194129944,
0.3494023084640503,
0.30330178141593933,
0.41316545009613037,
-0.2597702145576477,
-0.2506561875343323,
0.13753414154052734,
0.33849450945854187,
-0.029232988134026527,
-0.47243452072143555,
0.8773791790008545,
0.5192268490791321,
0.023571712896227837,
0.40444430708885193,
0.45172616839408875,
0.473746120929718,
-0.14955569803714752,
-0.6922560930252075,
-0.0627657100558281,
-0.03657490387558937,
0.26053833961486816,
0.42326778173446655,
0.28623130917549133,
-0.2493588924407959,
0.2393898367881775,
0.49796271324157715,
0.5776129961013794,
-0.02361082099378109,
-0.2047557234764099,
-0.2054317742586136,
0.7459514141082764,
0.29191237688064575,
-0.26570484042167664,
-0.3137708306312561,
0.44986841082572937,
-0.434810608625412,
-0.03195853531360626,
0.500041663646698,
-0.4214104413986206,
-0.34234619140625,
0.5399602055549622,
-0.4722854793071747,
0.2987262010574341,
-0.05031914636492729,
0.8403094410896301,
-0.4307555556297302,
0.20519931614398956,
0.0792902261018753,
-0.4321722984313965,
0.26771122217178345,
0.1336970031261444,
0.32458654046058655,
0.042839717119932175,
-0.8808122277259827,
0.47401902079582214,
-0.5677912831306458,
-0.3048599362373352,
0.09802654385566711,
0.22885142266750336,
0.47951382398605347,
-0.022697845473885536,
-0.7659215927124023,
0.5443794131278992,
-0.23672114312648773,
-0.40557071566581726,
-0.2645294964313507,
0.1909305900335312,
-0.6601660251617432,
-0.07797691971063614,
0.3461117744445801,
0.2277928590774536,
0.6149153113365173,
-0.6685323715209961,
0.5213139057159424,
-0.22294773161411285,
0.016188932582736015,
-0.09687753766775131,
0.12257739156484604,
0.1360592395067215,
0.35490816831588745,
-0.03839460015296936,
-0.3811323344707489,
0.7072015404701233,
-0.09940553456544876,
0.6115329265594482,
-0.23276543617248535,
0.48732221126556396,
-0.5128510594367981,
0.07111211121082306,
0.16427618265151978,
0.10176559537649155,
0.3851184546947479,
0.4310344457626343,
-0.00849743653088808,
0.2830912172794342,
0.35093075037002563,
0.13130183517932892,
-0.08608881384134293,
-0.45182427763938904,
0.014149154536426067,
-0.17967981100082397,
0.4135077893733978,
-0.4628960192203522,
0.11293845623731613,
-0.18700146675109863,
-0.6584340929985046,
0.1816444993019104,
0.5870950222015381,
0.40163949131965637,
-0.469000905752182,
0.44640496373176575,
-0.0921366736292839,
0.1440807282924652,
-0.5667487382888794,
0.15032534301280975,
-0.5676640868186951,
0.43583834171295166,
0.016155127435922623,
0.5325790047645569,
-0.2501993179321289,
-0.45412901043891907,
-0.4842495918273926,
0.04374120756983757,
-0.18470092117786407,
-0.011899716220796108,
0.44881004095077515,
-0.13432817161083221,
0.11147252470254898,
-0.723881185054779,
-0.9487398862838745,
-0.08385297656059265,
0.3954596519470215,
0.19800658524036407,
-0.7126052975654602,
-0.1499074101448059,
-0.15746450424194336,
-0.3118900954723358,
0.23191861808300018,
-0.23392057418823242,
0.22044216096401215,
0.8497301936149597
] |
BACKGROUND: Flavivirus infected cells produce infectious virions and subviral particles, both of which are formed by the assembly of prM and E envelope proteins and are believed to undergo the same maturation process. Dengue recombinant subviral particles have been produced in cell cultures with either modified or chimeric proteins but not using the native forms of prM and E. METHODOLOGY/PRINCIPAL FINDINGS: We have used a codon optimization strategy to obtain an efficient expression of native viral proteins and production of recombinant subviral particles (RSPs) for all four dengue virus (DV) serotypes. A stable HeLa cell line expressing DV1 prME was established (HeLa-prME) and RSPs were analyzed by immunofluorescence and transmission electron microscopy. We found that E protein is mainly present in the endoplasmic reticulum (ER) where assembly of RSPs could be observed. Biochemical characterization of DV1 RSPs secretion revealed both prM protein cleavage and homodimerization of E proteins before their release into the supernatant, indicating that RSPs undergo a similar maturation process as dengue virus. Pulse chase experiment showed that 8 hours are required for the secretion of DV1 RSPs. We have used HeLa-prME to develop a semi-quantitative assay and screened a human siRNA library targeting genes involved in membrane trafficking. Knockdown of 23 genes resulted in a significant reduction in DV RSP secretion, whereas for 22 others we observed an increase of RSP levels in cell supernatant. CONCLUSIONS/SIGNIFICANCE: Our data describe the efficient production of RSPs containing native prM and E envelope proteins for all dengue serotypes. Dengue RSPs and corresponding producing cell lines are safe and novel tools that can be used in the study of viral egress as well as in the development of vaccine and drugs against dengue virus. | [
0.005364055745303631,
0.011468105018138885,
-0.0010496890172362328,
0.011091742664575577,
-0.03427071124315262,
-0.022439535707235336,
0.011082746088504791,
0.029940200969576836,
-0.01714056171476841,
-0.03424958512187004,
-0.003687414340674877,
0.022914983332157135,
-0.017112527042627335,
0.008889030665159225,
0.00510091707110405,
-0.004982328042387962,
-0.0003782563144341111,
-0.0212839487940073,
0.005973543971776962,
0.034602873027324677,
0.02926868014037609,
-0.00014358782209455967,
0.011032957583665848,
-0.04109523072838783,
0.020615195855498314,
0.027401182800531387,
0.003917312249541283,
-0.0012313290499150753,
-0.05168202146887779,
-0.00325579009950161,
0.0328754298388958,
-0.0002186954952776432,
-0.010504646226763725,
-0.010733877308666706,
-0.010240605100989342,
-0.007604786194860935,
-0.009185660630464554,
0.025560690090060234,
0.021898988634347916,
-0.004375576972961426,
-0.005233462899923325,
-0.010452643036842346,
0.0020271241664886475,
0.00447841314598918,
-0.009728522971272469,
-0.02092926576733589,
-0.002437809482216835,
0.022800229489803314,
-0.004430258646607399,
-0.0037340782582759857,
-0.012412014417350292,
-0.0016423012129962444,
-0.011312678456306458,
0.04212142154574394,
-0.007941841147840023,
-0.022336747497320175,
0.021403640508651733,
-0.015283830463886261,
-0.011747969314455986,
0.02207837626338005,
0.014374976977705956,
-0.006414379924535751,
0.0040031541138887405,
-0.0008120154961943626,
0.025764290243387222,
-0.0664277896285057,
-0.008703294210135937,
-0.015176425687968731,
0.006212668959051371,
-0.00847228616476059,
0.008182663470506668,
0.010784653946757317,
-0.017284013330936432,
-0.0003734743222594261,
-0.02650352194905281,
-0.03871254622936249,
-0.01098642684519291,
0.037632640451192856,
-0.03921370208263397,
-0.0041548991575837135,
0.010559409856796265,
-0.004496383015066385,
0.0010145334526896477,
-0.0019890828989446163,
0.01331719383597374,
0.018732983618974686,
-0.012996014207601547,
0.02089330554008484,
-0.031026717275381088,
-0.01493123546242714,
0.004897146485745907,
-0.002325447741895914,
-0.03333315998315811,
-0.0015448103658854961,
0.02081695757806301,
-0.0017737358575686812,
-0.004960954189300537,
-0.05076916515827179,
-0.0036265309900045395,
-0.01711774803698063,
-0.017887555062770844,
0.02703435719013214,
0.01369144394993782,
0.011736186221241951,
0.011368178762495518,
0.013213388621807098,
0.0004634545184671879,
0.030080435797572136,
0.027747217565774918,
0.010280812159180641,
0.004761527292430401,
-0.013237305916845798,
0.01902565360069275,
0.00886480137705803,
-0.005385392811149359,
-0.012649125419557095,
0.02213151380419731,
0.024318143725395203,
0.011217684485018253,
0.0038021202199161053,
-0.0029267112258821726,
0.00541544146835804,
0.0032039391808211803,
-0.02816491574048996,
0.003355366177856922,
-0.02519582211971283,
0.008259762078523636,
-0.01666910946369171,
0.03257706016302109,
-0.00035700935404747725,
-0.012096695601940155,
-0.0041322289034724236,
-0.022722460329532623,
-0.02852771058678627,
-0.0028239982202649117,
0.01017446257174015,
-0.00408320315182209,
-0.01169835589826107,
0.01823943294584751,
-0.019115881994366646,
-0.01786547712981701,
0.009298162534832954,
0.006642278283834457,
0.013967052102088928,
0.01197491679340601,
0.001888199825771153,
-0.032129593193531036,
-0.000897659920156002,
0.008853071369230747,
-0.03312161937355995,
0.027074620127677917,
0.005330507177859545,
0.016836104914546013,
-0.010697981342673302,
0.019179970026016235,
-0.02113453298807144,
-0.02163292095065117,
-0.05278533324599266,
-0.0007113096071407199,
0.010695787146687508,
0.000443905359134078,
-0.04342149198055267,
0.03328862413764,
0.01184694841504097,
0.017491912469267845,
-0.006344800814986229,
0.013867896050214767,
-0.017291508615016937,
-0.007037357427179813,
0.007845405489206314,
0.0007938484195619822,
0.019318440929055214,
-0.009148845449090004,
0.01314345933496952,
0.024575553834438324,
-0.009326381608843803,
0.010782052762806416,
0.007131718099117279,
-0.025776702910661697,
0.06627063453197479,
-0.02026645839214325,
-0.0019001653417944908,
0.0007826017681509256,
-0.01161179132759571,
-0.004820270463824272,
-0.0067078908905386925,
0.014126589521765709,
-0.009053857997059822,
0.002013519871979952,
-0.006156583782285452,
0.002423456870019436,
-0.0007464669179171324,
-0.014403085224330425,
-0.01912207342684269,
-0.0005001859972253442,
0.003363523166626692,
0.024825192987918854,
0.01910710521042347,
0.01000940427184105,
-0.00651151267811656,
0.013677820563316345,
0.0031656427308917046,
0.014491884969174862,
0.014424286782741547,
-0.01970439776778221,
0.006232609041035175,
-0.015934674069285393,
-0.01288851909339428,
-0.006804466247558594,
-0.011085090227425098,
0.010365910828113556,
-0.01654926873743534,
-0.00354185001924634,
-0.007406795397400856,
0.008329052478075027,
-0.0074415975250303745,
-0.010888182558119297,
0.011462269350886345,
-0.004489600658416748,
-0.015410909429192543,
-0.004034171346575022,
0.009202886372804642,
-0.029158305376768112,
0.012663090601563454,
-0.007678898982703686,
0.003214147174730897,
-0.004937649704515934,
0.013624759390950203,
-0.012481195852160454,
0.0015217950567603111,
0.01960643194615841,
-0.052171558141708374,
-0.019691310822963715,
-0.011415356770157814,
0.04261656105518341,
-0.004592488054186106,
0.014081031084060669,
-0.019156962633132935,
0.009998776018619537,
-0.009731415659189224,
-0.011013804003596306,
0.015290754847228527,
0.01718459650874138,
0.011484192684292793,
0.025801826268434525,
-0.021866604685783386,
0.009558908641338348,
-0.01339135505259037,
0.039177682250738144,
-0.014452721923589706,
0.011190811172127724,
-0.002301943488419056,
0.010247800499200821,
-0.021305769681930542,
0.04708635434508324,
0.011614039540290833,
0.011179383844137192,
0.012997320853173733,
0.02474072016775608,
0.00025622546672821045,
-0.002116455463692546,
0.0083856713026762,
-0.022057360038161278,
-0.00010983552783727646,
0.0036569652147591114,
0.02421802282333374,
-0.02034047245979309,
-0.006407342851161957,
0.0018178420141339302,
0.006106685847043991,
0.01395126711577177,
-0.01144822221249342,
-0.003480697749182582,
-0.08094373345375061,
-0.023227404803037643,
0.021293897181749344,
-0.008306259289383888,
0.004530651494860649,
0.002653728239238262,
0.012197489850223064,
-0.017813293263316154,
-0.002402805257588625,
0.012209046632051468,
0.0012672136072069407,
0.014882683753967285,
-0.011354701593518257,
-0.015517113730311394,
-0.006194738671183586,
-0.009204436093568802,
0.010277237743139267,
-0.007870182394981384,
-0.023808296769857407,
-0.013408659026026726,
-0.03979245573282242,
0.03304152190685272,
0.018975762650370598,
0.00022850977256894112,
0.003914579749107361,
0.013017239049077034,
0.008722977712750435,
0.011165814474225044,
0.009023057296872139,
0.000634289812296629,
0.0004894435405731201,
-0.01907338574528694,
0.02635052800178528,
-0.01582236774265766,
0.03538083657622337,
0.008573517203330994,
-0.004915694240480661,
-0.01316477544605732,
-0.029983332380652428,
0.01883339136838913,
-0.015181049704551697,
0.018978480249643326,
0.01627769134938717,
0.009184606373310089,
0.025128718465566635,
0.005030663684010506,
-0.011560552753508091,
0.03636135533452034,
0.02496899664402008,
0.01978045143187046,
-0.03869064152240753,
-0.0032520126551389694,
0.021574750542640686,
0.023226298391819,
-0.01078549399971962,
0.0034356892574578524,
-0.013544758781790733,
0.042506471276283264,
-0.0062174410559237,
-0.002181851305067539,
-0.03004889190196991,
0.005915891844779253,
-0.015524030663073063,
-0.0006957659497857094,
-0.006719806231558323,
0.03366314247250557,
0.01712663471698761,
0.01068903785198927,
-0.01864846982061863,
0.03768996149301529,
-0.019832011312246323,
0.01027007307857275,
-0.0037055336870253086,
-0.014453119598329067,
-0.01974528655409813,
-0.00590010778978467,
-0.017367394641041756,
-0.013833710923790932,
-0.007854683324694633,
-0.04149067774415016,
-0.06182433292269707,
0.006750576198101044,
-0.029731212183833122,
0.006530385930091143,
-0.022985948249697685,
-0.005005530081689358,
0.007153738755732775,
0.04707399755716324,
0.0011294563300907612,
-0.020512403920292854,
0.03417372703552246,
0.009152478538453579,
-0.014329405501484871,
0.01164131797850132,
-0.017371047288179398,
-0.029227986931800842,
-0.014143753796815872,
0.024727560579776764,
-0.015565359964966774,
0.010137981735169888,
-0.022650590166449547,
-0.010658212006092072,
-0.027303921058773994,
-0.007356022484600544,
-0.04013288393616676,
0.013503503054380417,
-0.017485953867435455,
-0.008039877749979496,
0.01844794675707817,
-0.007455286104232073,
-0.0020145580638200045,
0.031271178275346756,
-0.007626354694366455,
-0.008114482276141644,
0.015353123657405376,
0.0031884126365184784,
0.008743418380618095,
0.002765430137515068,
0.07162142544984818,
0.009724828414618969,
-0.00480672437697649,
-0.018984906375408173,
-0.015865422785282135,
-0.012892233207821846,
-0.009612351655960083,
0.011098774150013924,
-0.03827673941850662,
-0.016543928533792496,
0.013526788912713528,
-0.014540541917085648,
0.0026923147961497307,
-0.02984788455069065,
-0.025790182873606682,
-0.00912538543343544,
0.014866843819618225,
-0.03984694182872772,
0.027322029694914818,
0.003457877319306135,
0.0024014608934521675,
-0.027859121561050415,
0.0020298869349062443,
-0.0059012118726968765,
0.016588622704148293,
0.0008625918999314308,
0.03745217248797417,
-0.011993715539574623,
-0.025197843089699745,
0.005825455766171217,
0.0024642013013362885,
-0.014462083578109741,
-0.007049122825264931,
0.01592833362519741,
0.05424051731824875,
0.010318757966160774,
-0.02010956034064293,
-0.003991176374256611,
-0.01427114475518465,
-0.021221905946731567,
-0.013812807388603687,
-0.010673509910702705,
-0.022239908576011658,
0.009074706584215164,
-0.02402026206254959,
-0.031928081065416336,
0.021754642948508263,
-0.01195642352104187,
-0.014089313335716724,
-0.015524479560554028,
-0.005184365436434746,
0.010337447747588158,
0.012983821332454681,
0.018863029778003693,
-0.011437000706791878,
-0.03331858664751053,
0.008314698934555054,
-0.004946345463395119,
0.022183336317539215,
-0.010525980032980442,
-0.006809594109654427,
-0.003550089430063963,
0.00966041348874569,
-0.03652742877602577,
0.01869041472673416,
-0.02437901496887207,
-0.00328510208055377,
-0.000535724451765418,
-0.024747734889388084,
0.0003551989793777466,
0.038207992911338806,
0.00625686114653945,
-0.0011664651101455092,
0.00843166932463646,
-0.03354552388191223,
0.007495112717151642,
-0.0001890223938971758,
0.006868526339530945,
0.01886616460978985,
0.0023526435252279043,
0.03991047665476799,
0.022333558648824692,
0.033250682055950165,
0.011236444115638733,
-0.0070822034031152725,
-0.015044626779854298,
-0.004143750295042992,
-0.0740261971950531,
-0.01859542913734913,
0.01377412211149931,
-0.0052495733834803104,
0.024305127561092377,
0.00758372712880373,
-0.020061945542693138,
0.012987839058041573,
-0.023669108748435974,
-0.002507734578102827,
0.011512539349496365,
0.0092853382229805,
0.018215728923678398,
-0.00009322818368673325,
0.015477273613214493,
-0.014945713803172112,
0.010373085737228394,
0.0010904984083026648,
-0.0018627996323630214,
0.0025599338114261627,
0.02924416773021221,
-0.022546030580997467,
-0.027343157678842545,
0.009517444297671318,
-0.005829961970448494,
-0.0803636759519577,
-0.0022383658215403557,
0.002478534821420908,
-0.030505109578371048,
0.005152805708348751,
-0.01894802786409855,
0.01450870931148529,
-0.012212052009999752,
0.016711074858903885,
-0.016394954174757004,
0.02240723744034767,
0.0024321461096405983,
0.006019372493028641,
-0.0009150655241683125,
0.006047360599040985,
-0.0021906420588493347,
-0.0013508936390280724,
-0.018147818744182587,
-0.0041464343667030334,
-0.027738913893699646,
0.02484475076198578,
0.025074921548366547,
-0.012913024052977562,
-0.004233220592141151,
0.00019447010708972812,
-0.013821649365127087,
-0.004556141793727875,
0.011953162029385567,
0.01625341922044754,
-0.004294917918741703,
-0.011760927736759186,
0.012652119621634483,
-0.009647495113313198,
-0.03140595555305481,
0.033393263816833496,
-0.022386372089385986,
0.03464746102690697,
0.020089041441679,
0.009932335466146469,
-0.010520653799176216,
-0.011321647092700005,
0.008531301282346249,
0.021604472771286964,
0.02465258352458477,
-0.004982393234968185,
-0.00897353608161211,
0.009248830378055573,
-0.015375974588096142,
0.03175235167145729,
-0.0017430682200938463,
0.0038971237372606993,
-0.018073540180921555,
-0.022126344963908195,
0.00032212212681770325,
0.017226414754986763,
0.003422918263822794,
0.006712185684591532,
-0.009006514213979244,
-0.013683043420314789,
0.009643903002142906,
-0.0008105405140668154,
-0.0015023453161120415,
-0.008804874494671822,
0.07117976248264313,
-0.01308171171694994,
0.018405761569738388,
-0.030549395829439163,
0.003050696337595582,
0.0039031950291246176,
-0.03371385112404823,
-0.0007647238671779633,
-0.008026603609323502,
-0.02291249856352806,
0.030840646475553513,
-0.002471448155120015,
-0.018053341656923294,
0.01393970288336277,
0.014156758785247803,
0.01054936833679676,
-0.003702110145241022,
0.013865702785551548,
-0.023536771535873413,
0.023634903132915497,
-0.01746172085404396,
-0.012380795553326607,
-0.024377774447202682,
-0.023408230394124985,
0.017733175307512283,
0.003997255116701126,
0.006649079732596874,
0.019962795078754425,
-0.007695605978369713,
0.011766898445785046,
-0.016362203285098076,
-0.0058733392506837845,
-0.003317560302093625,
-0.024576639756560326,
0.013645688071846962,
0.02373189479112625,
0.0006679845973849297,
0.008247541263699532,
-0.010429255664348602,
0.030298560857772827,
-0.020822403952479362,
0.018747247755527496,
-0.00745699368417263,
-0.02010584995150566,
0.010366637259721756,
-0.039423681795597076,
-0.0030315450858324766,
-0.0023047421127557755,
0.0043998826295137405,
0.01990022510290146,
0.005125586409121752,
0.010626055300235748,
0.04224845767021179,
0.0018661837093532085,
0.0038295688573271036,
0.0007266744505614042,
-0.010744668543338776,
0.027439534664154053,
-0.016324639320373535,
0.01811886578798294,
0.006318368948996067,
-0.0180433951318264,
0.028094541281461716,
-0.02303553745150566,
0.017110398039221764,
-0.03553053364157677,
0.009433119557797909,
-0.011833367869257927,
-0.040079325437545776,
0.013452918268740177,
-0.02088160440325737,
0.010248416103422642,
0.004049471579492092,
0.001311211846768856,
0.016268223524093628,
0.013402100652456284,
0.036552250385284424,
0.03516291454434395,
0.013135271146893501,
0.03061847761273384,
-0.004426843021064997,
-0.005318553186953068,
0.030684489756822586,
0.027379773557186127,
-0.008192325942218304,
-0.011411402374505997,
-0.007016947027295828,
0.013239525258541107,
0.006685574539005756,
0.010821647942066193,
0.01600693352520466,
-0.0043317051604390144,
0.0047331685200333595,
0.03445933014154434,
0.011814093217253685,
0.03483856841921806,
0.033671408891677856,
0.004419704433530569,
0.007906057871878147,
0.007708226330578327,
-0.0006130067631602287,
-0.03542821854352951,
-0.029161395505070686,
0.01775621995329857,
0.0025636088103055954,
-0.01566980592906475,
0.02778562903404236,
0.0006774323992431164,
0.001933784456923604,
-0.02434595301747322,
0.0009577292948961258,
0.011436876840889454,
0.015961632132530212,
0.014615895226597786,
-0.006554071791470051,
0.013399302959442139,
-0.016344554722309113,
-0.025307927280664444,
0.005654106382280588,
-0.013311152346432209,
-0.022710006684064865,
-0.016066843643784523,
0.013995815068483353,
0.0314122699201107,
-0.009216384962201118,
-0.018532773479819298,
-0.009155170992016792,
-0.006895014084875584,
-0.006482183933258057,
0.002473247703164816,
0.023148125037550926,
0.02609477937221527,
-0.004464468918740749,
0.008220218122005463,
0.002376905642449856,
-0.01773616299033165,
0.024819334968924522,
0.01678379438817501,
0.003876058617606759,
-0.048614006489515305,
-0.0015301676467061043,
-0.007588769309222698,
0.0027900454588234425,
-0.01669626496732235,
0.00898711197078228,
-0.0007196066435426474,
0.022483212873339653,
-0.011125253513455391,
0.00512546906247735,
0.010488519445061684,
0.008414993062615395,
0.01382211223244667,
0.010461010970175266,
-0.00795549713075161,
0.03238964453339577,
0.009467387571930885,
-0.0005290795816108584,
-0.02845085598528385,
0.018655123189091682,
0.015656795352697372,
-0.0019829135853797197,
0.0074646957218647,
-0.004558130167424679,
0.0035915877670049667,
-0.004266287200152874,
0.029639434069395065,
0.020810414105653763,
0.009555712342262268,
0.0015063667669892311,
0.018299823626875877,
0.011303765699267387,
-0.03204464539885521,
0.016932949423789978,
0.012806423008441925,
-0.039341650903224945,
-0.012196032330393791,
-0.009806476533412933,
-0.018118131905794144,
-0.012605685740709305,
-0.010113353841006756,
0.00006240233778953552,
-0.02051645889878273,
0.032942697405815125,
-0.00631983857601881,
-0.0290056299418211,
-0.03103669360280037,
0.0028449343517422676,
0.035795435309410095,
-0.005403053481131792,
-0.0075812628492712975,
-0.0019444236531853676,
-0.006592455320060253,
-0.0075619835406541824,
0.0244220532476902,
-0.013615257106721401,
0.00366813107393682,
0.005825922824442387,
-0.01472978014498949,
0.00512082502245903,
0.033933788537979126,
-0.01536062452942133,
0.005118673667311668
] | [
0.5862823724746704,
-0.20209833979606628,
-0.09942716360092163,
0.27776578068733215,
0.32188427448272705,
0.008826897479593754,
-0.033374931663274765,
0.42671099305152893,
-0.29288628697395325,
-0.29436448216438293,
0.14368654787540436,
0.15763059258460999,
-0.11454223096370697,
0.17557618021965027,
-0.2671376168727875,
0.9251683354377747,
0.43206050992012024,
0.5523085594177246,
0.11333637684583664,
-0.30974718928337097,
-0.39180633425712585,
-0.03324362635612488,
0.10582928359508514,
-0.014681216329336166,
-0.06690789759159088,
-0.156150221824646,
0.479449599981308,
-0.005253870505839586,
0.3303791582584381,
-0.24312502145767212,
0.019511569291353226,
0.39560526609420776,
-0.06815532594919205,
-0.11313148587942123,
-0.009102635085582733,
-0.5912618637084961,
-0.22102947533130646,
0.367509663105011,
0.22533223032951355,
-0.451836496591568,
-0.2846822440624237,
-0.2969977557659149,
-0.11793648451566696,
0.22032052278518677,
-0.0031637614592909813,
-0.9124288558959961,
-1.0494107007980347,
0.6332519054412842,
-0.3777233064174652,
0.005069849546998739,
0.36579862236976624,
0.31694793701171875,
-0.10842770338058472,
0.24239757657051086,
0.05981595069169998,
0.24598047137260437,
-0.5311256051063538,
-0.19868908822536469,
0.3584405779838562,
-0.3917616903781891,
0.008537158370018005,
-0.30773454904556274,
-0.44573450088500977,
0.2123572677373886,
-0.09139535576105118,
0.5960635542869568,
0.16800202429294586,
0.002512599341571331,
-0.3057368993759155,
-0.46631842851638794,
0.2607058584690094,
-0.05025174096226692,
-0.22318759560585022,
0.02758435718715191,
0.19120270013809204,
-0.048325005918741226,
0.020604684948921204,
-0.1673271507024765,
0.1467299461364746,
-0.011989159509539604,
-0.06111104413866997,
-0.4065404236316681,
-0.009433234110474586,
-0.36264151334762573,
0.7121289968490601,
0.37021180987358093,
-0.09035663306713104,
0.3510551452636719,
-0.22128111124038696,
-0.04848422482609749,
-0.22647589445114136,
-0.08398967981338501,
0.19669334590435028,
0.8133657574653625,
-0.001339879003353417,
0.11122399568557739,
-0.06750701367855072,
0.08162391930818558,
0.0755060687661171,
0.1567716896533966,
-0.7848185300827026,
-0.09992809593677521,
-0.11647329479455948,
-0.19520090520381927,
-0.4333038032054901,
0.07591243833303452,
-0.383352667093277,
-0.39736494421958923,
-0.7321555018424988,
0.34804704785346985,
-0.3018325865268707,
-0.11824652552604675,
-0.25322726368904114,
-0.13741107285022736,
-0.31114333868026733,
-0.05352766811847687,
0.22471915185451508,
-0.644842267036438,
-0.17695505917072296,
0.694453775882721,
-0.24478887021541595,
1.2840262651443481,
-0.32539111375808716,
0.33121469616889954,
0.19691933691501617,
0.06707759946584702,
0.2692124545574188,
0.4649488031864166,
-0.22462306916713715,
0.6887155771255493,
0.6106515526771545,
0.9432063698768616,
-0.5244696736335754,
0.6011415123939514,
-0.2382173091173172,
-0.22723668813705444,
0.18358537554740906,
0.4032573401927948,
0.20220281183719635,
-0.06591160595417023,
-0.880665123462677,
-0.40991246700286865,
-0.19278526306152344,
0.2123938798904419,
-0.20078079402446747,
-0.5472458004951477,
-0.30143648386001587,
-0.15088050067424774,
-0.34743359684944153,
-0.3318457007408142,
0.04605485498905182,
-0.47657743096351624,
-0.5434895753860474,
-0.14635823667049408,
0.03520272672176361,
0.4200408458709717,
0.18891790509223938,
-0.16373033821582794,
-0.5303959250450134,
0.6063289046287537,
0.28466734290122986,
0.5000828504562378,
-0.45016106963157654,
0.024660460650920868,
0.5770654082298279,
-0.13173554837703705,
0.3941963315010071,
0.4501815140247345,
-0.18791259825229645,
0.06492212414741516,
-0.4025179445743561,
-0.1295967996120453,
-0.09218956530094147,
-0.691787838935852,
0.07715939730405807,
0.2510652542114258,
-0.015178636647760868,
-0.03852955996990204,
0.3344016671180725,
0.1422266811132431,
-0.5634193420410156,
0.17091888189315796,
-0.3155002295970917,
-0.496563583612442,
0.03823724389076233,
0.174107164144516,
0.24274741113185883,
0.16652977466583252,
-0.10933153331279755,
-0.22484023869037628,
-0.7811046838760376,
-0.1326415240764618,
0.4811868965625763,
-0.6261203289031982,
1.1083112955093384,
-0.39722105860710144,
-0.03639492765069008,
1.5472763776779175,
0.024444470182061195,
0.31084391474723816,
0.008696500211954117,
0.05829939246177673,
0.3284197151660919,
-0.4395328462123871,
-0.5068196058273315,
0.371067613363266,
0.4057065546512604,
-0.196424201130867,
0.1641479879617691,
-0.09022874385118484,
0.7399678826332092,
0.08803804963827133,
-0.03143101930618286,
-0.10045017302036285,
0.10945109277963638,
0.21411778032779694,
-0.4382353723049164,
-0.3767031729221344,
0.11440807580947876,
-0.10157394409179688,
0.5051301717758179,
-0.7543091773986816,
0.4455544948577881,
0.6470768451690674,
-0.18952849507331848,
0.6167194843292236,
0.3542371392250061,
-0.025764983147382736,
1.0699262619018555,
-0.4129990339279175,
0.22067099809646606,
-0.3151889741420746,
0.2979079782962799,
-0.7820833921432495,
-0.5188543796539307,
0.1837596744298935,
-0.11153267323970795,
0.36897012591362,
0.14442522823810577,
0.4534461498260498,
0.2168664038181305,
0.5502998232841492,
-0.8064354658126831,
-0.28330090641975403,
-0.21905069053173065,
-0.442908376455307,
-0.6308194994926453,
0.19352395832538605,
-0.6200292706489563,
-0.27887728810310364,
0.2553095519542694,
0.47266095876693726,
0.01988167129456997,
-0.5710926651954651,
0.2963741421699524,
0.3589839041233063,
-0.3724348247051239,
-0.18186308443546295,
0.37569522857666016,
-0.16520172357559204,
-0.1347718983888626,
0.4050092399120331,
0.06700657308101654,
0.2532435357570648,
0.37265920639038086,
-0.34617722034454346,
-0.6379293203353882,
-0.5510676503181458,
0.7852448225021362,
0.5906252861022949,
0.5057921409606934,
-0.0327598936855793,
-0.5657515525817871,
0.23736941814422607,
0.07340767234563828,
-0.7760392427444458,
0.18337659537792206,
0.7004404067993164,
-0.6848981380462646,
-0.5650517344474792,
-0.38594239950180054,
-0.11906470358371735,
0.8711315989494324,
-0.32067322731018066,
-0.42979127168655396,
-0.6367162466049194,
-0.05257507413625717,
-0.04133407399058342,
-0.7331347465515137,
-0.2987990081310272,
-0.1033974140882492,
0.39835047721862793,
-0.10070641338825226,
0.01684299297630787,
0.044166214764118195,
0.7304037809371948,
-0.00920813623815775,
0.08417455106973648,
0.6228978037834167,
-0.17084592580795288,
-0.028933178633451462,
0.40923911333084106,
-0.18290859460830688,
-0.2661597728729248,
0.02521163783967495,
0.058908626437187195,
-0.5927793979644775,
0.1940183788537979,
-5.874962329864502,
0.3986414968967438,
-0.24743974208831787,
-0.022111762315034866,
-0.12870119512081146,
-0.1180376335978508,
1.287521481513977,
-0.00933612510561943,
0.3817191421985626,
-0.5003496408462524,
0.34897732734680176,
0.39190196990966797,
-0.3271944224834442,
-0.031073004007339478,
0.01075117290019989,
0.1289353370666504,
0.6591574549674988,
-0.04584694653749466,
0.668283224105835,
0.6403848528862,
-0.36907538771629333,
-0.070094533264637,
-0.05906074121594429,
0.1441354751586914,
0.45153141021728516,
0.6092168688774109,
-0.9833396077156067,
0.041549522429704666,
-0.07741305232048035,
0.03434906154870987,
0.39253610372543335,
-0.7060720920562744,
-0.06769095361232758,
-0.40370598435401917,
-0.13991090655326843,
-0.06176178157329559,
0.05387232452630997,
-0.24713481962680817,
0.198136568069458,
-0.12912625074386597,
0.4539380371570587,
0.5437215566635132,
-0.2372659146785736,
-0.10661815106868744,
-0.19332976639270782,
-0.16967202723026276,
0.07500549405813217,
0.12317178398370743,
-0.1242985874414444,
1.259195327758789,
-0.3092225193977356,
-0.26924997568130493,
0.2565532326698303,
0.29344382882118225,
0.21615727245807648,
-0.060893379151821136,
-0.13634106516838074,
0.3744581937789917,
-0.21437779068946838,
0.06071531027555466,
-0.03183872625231743,
-0.43655210733413696,
0.07068197429180145,
-0.40354079008102417,
0.24786287546157837,
0.3302938938140869,
-0.6313419342041016,
-0.37078309059143066,
0.23227514326572418,
0.1919727623462677,
-0.20591385662555695,
0.09845156967639923,
0.036559902131557465,
-0.6108428835868835,
0.10292112082242966,
-0.45825067162513733,
-0.43220052123069763,
-0.4661397635936737,
0.11748891323804855,
-0.34458956122398376,
0.030902082100510597,
-0.34880533814430237,
0.08458752930164337,
-0.1670154631137848,
0.01998247019946575,
-0.14610768854618073,
0.01219958532601595,
-0.1191876009106636,
-0.2871788442134857,
0.1817294955253601,
0.6705693602561951,
-0.454624205827713,
0.14931249618530273,
0.07779484987258911,
0.5323355793952942,
0.7293980121612549,
0.6159669160842896,
0.0674201101064682,
0.05047910660505295,
-0.2120831459760666,
0.9025281071662903,
-0.5136464834213257,
-0.2676924765110016,
-1.1554393768310547,
-0.03481510654091835,
0.14166298508644104,
-0.40727806091308594,
0.2520734965801239,
0.49673086404800415,
-0.6755169630050659,
0.28479745984077454,
-0.10699152946472168,
-0.3910302221775055,
0.030820239335298538,
0.7905052900314331,
-0.30631139874458313,
0.42749151587486267,
-0.0641583800315857,
0.77053302526474,
-0.3666774034500122,
0.67454993724823,
0.312192440032959,
-0.3717121183872223,
0.3749125301837921,
-0.20951148867607117,
-0.5255542993545532,
0.42056918144226074,
0.41041848063468933,
-0.3680129945278168,
-0.402498334646225,
0.029577814042568207,
0.12749391794204712,
-0.46943679451942444,
-0.27467086911201477,
0.1977107971906662,
0.016833528876304626,
-0.5016766786575317,
-0.49639707803726196,
0.3093617856502533,
-0.114336758852005,
0.07146474719047546,
-0.005927848629653454,
-0.16047467291355133,
0.38577336072921753,
0.35746872425079346,
0.1483362317085266,
-0.10826444625854492,
0.08728418499231339,
-0.15299098193645477,
-0.40359556674957275,
0.24784666299819946,
0.23281118273735046,
0.2742319703102112,
-0.11856658011674881,
-0.48601680994033813,
0.24097703397274017,
0.7333111763000488,
0.014687488786876202,
0.47546660900115967,
-0.605900764465332,
0.545713484287262,
0.11243493854999542,
-0.9820430874824524,
0.33591943979263306,
0.12781912088394165,
-0.5579461455345154,
0.2734224498271942,
-0.5379126667976379,
0.09381209313869476,
0.33658960461616516,
-0.3911161422729492,
-0.192548468708992,
-0.03464572876691818,
-0.3037000298500061,
0.09192080795764923,
0.06948880106210709,
-0.3026416003704071,
0.11074446886777878,
0.03533469885587692,
0.09760729968547821,
0.12074202299118042,
-0.14641131460666656,
-0.36583811044692993,
0.6075275540351868,
0.9567689299583435,
0.537102997303009,
0.045140571892261505,
0.03681964427232742,
-0.5460993647575378,
-0.17683811485767365,
0.3383617699146271,
0.5197543501853943,
0.5604744553565979,
-0.09821612387895584,
-0.23221451044082642,
-0.29779431223869324,
-0.22455984354019165,
0.4958655536174774,
0.20677128434181213,
-0.47545504570007324,
-0.028200043365359306,
0.5396658778190613,
-0.21962904930114746,
0.5489763617515564,
-0.18760742247104645,
0.11241438239812851,
0.11552625149488449,
-0.2690404951572418,
0.08549734950065613,
-0.30169740319252014,
0.018798889592289925,
-0.550416111946106,
-0.07363414764404297,
0.47637999057769775,
-0.47975122928619385,
0.16302737593650818,
0.029401259496808052,
-0.18704000115394592,
-0.1222396269440651,
0.5397831201553345,
0.0006864891038276255,
-0.08054950088262558,
0.004429556429386139,
0.054453570395708084,
0.056903377175331116,
0.25926846265792847,
0.5750322341918945,
-1.0098129510879517,
-0.45457008481025696,
0.3793924152851105,
-0.2564787268638611,
-0.3661649525165558,
0.6113973259925842,
-0.02822718396782875,
-1.1260402202606201,
0.09264781326055527,
-0.17777644097805023,
-0.1305355578660965,
-0.06773782521486282,
0.19684894382953644,
0.5610865950584412,
0.2273118793964386,
-0.46681633591651917,
-0.7688778638839722,
-0.10321001708507538,
0.2728644609451294,
0.31426504254341125,
-0.19298860430717468,
-0.4017360806465149,
0.2864137291908264,
0.1451454609632492,
-0.10487985610961914,
0.008400456979870796,
0.10746804624795914,
0.5766439437866211,
0.13763709366321564,
-0.03712083399295807,
-0.3302062153816223,
-0.08010020107030869,
0.1643114984035492,
-0.0933784544467926,
-0.30039525032043457,
-0.1529470533132553,
-0.4931522309780121,
-0.17324478924274445,
-0.15794695913791656,
-0.18095393478870392,
-0.23243556916713715,
0.3340006172657013,
0.09468872845172882,
-0.24213120341300964,
0.034501396119594574,
0.8463624119758606,
0.6566771864891052,
-0.21235240995883942,
0.21315021812915802,
-0.405739426612854,
0.2106827348470688,
-0.5807924866676331,
0.47090092301368713,
-0.6743567585945129,
-0.7955179214477539,
0.17629636824131012,
-0.18224996328353882,
0.10031021386384964,
-0.34340623021125793,
0.19692832231521606,
0.035159967839717865,
0.2518741190433502,
-0.564070463180542,
-0.3465732932090759,
-0.19406692683696747,
-0.5140706896781921,
-0.6644917130470276,
0.0866379514336586,
0.15577742457389832,
-0.20394890010356903,
0.190337136387825,
0.149525448679924,
-0.6280696392059326,
-0.361572265625,
0.6775938272476196,
0.4003324508666992,
-0.40735241770744324,
0.6489105224609375,
-0.08028976619243622,
0.15158478915691376,
0.5201890468597412,
-0.12769721448421478,
-0.14697265625,
0.518068253993988,
-0.05305854603648186,
0.23196576535701752,
-0.19396379590034485,
-0.2557707726955414,
0.06348849087953568,
-0.16457387804985046,
-0.5622239112854004,
0.4407690167427063,
0.13662855327129364,
0.7079942226409912,
0.57252436876297,
0.48252028226852417,
-0.279744029045105,
-0.36646848917007446,
0.9134171605110168,
-0.34740760922431946,
0.06064756587147713,
0.06986340880393982,
-0.12923388183116913,
0.3441320061683655,
0.627960205078125,
-0.3508208990097046,
0.08470887690782547,
-0.09969978034496307,
0.7988074421882629,
0.6195619106292725,
-0.45852431654930115,
0.005951217841356993,
-0.05725422501564026,
0.5674270987510681,
0.47718721628189087,
0.09549426287412643,
-0.5360398292541504,
-0.13884148001670837,
0.008685369975864887,
-0.30389487743377686,
0.0949936956167221,
0.014036288484930992,
0.27438661456108093,
-0.017785804346203804,
-0.4413406550884247,
-0.2041284143924713,
0.16684740781784058,
-0.019343730062246323,
-0.17618277668952942,
0.14025211334228516,
-0.2739248275756836,
-0.9642373919487,
0.027200428768992424,
-0.26168182492256165,
0.4153669476509094,
-0.2260761260986328,
0.6194880604743958,
-0.2194511890411377,
0.12041555345058441,
0.5104472637176514,
0.4559653699398041,
-0.059298448264598846,
-0.39555197954177856,
-0.14036640524864197,
-0.4647015631198883,
0.01430712640285492,
0.44620800018310547,
0.4200723171234131,
-0.28044864535331726,
0.16016386449337006,
0.3129780888557434,
-0.5350902080535889,
0.47488364577293396,
-0.3185677230358124,
-0.011857595294713974,
-0.08067008852958679,
-0.05663781240582466,
0.06307192146778107,
-0.2846408486366272,
-0.25782510638237,
-0.3073684573173523,
0.05212237313389778,
-0.13129231333732605,
0.07471591979265213,
-1.0395551919937134,
0.01644633337855339,
0.3341755270957947,
-0.07759825885295868,
0.06343656033277512,
-0.20564380288124084,
0.7849069237709045,
0.2685745656490326,
0.1473204791545868,
-0.0534517839550972,
0.0709819421172142,
-0.1997353434562683,
0.610813319683075,
-0.5866913199424744,
0.5158048868179321,
-0.5595129728317261,
0.013985163532197475,
-0.8220345377922058,
-0.0831814780831337,
0.7871027588844299,
0.285783976316452,
-0.3889327347278595,
-0.09784991294145584,
-0.17895177006721497,
0.2714546322822571,
0.2038932591676712,
-0.3622995913028717,
0.016725346446037292,
-0.29320600628852844,
-0.29071465134620667,
-0.5249143242835999,
0.44376954436302185,
0.06350818276405334,
-0.04622090980410576,
-0.48490557074546814,
0.03649148344993591,
1.0710521936416626,
-0.7924225926399231,
0.2756859064102173,
-0.21359458565711975,
-0.21602365374565125,
-0.19898569583892822,
0.5965511202812195,
-0.7125468850135803,
0.40432441234588623,
0.08171015977859497,
0.5721962451934814,
0.05119280517101288,
-0.3470292091369629,
0.28043046593666077,
-0.33770933747291565,
0.259498655796051,
0.09315114468336105,
-0.09481669962406158,
0.2708117365837097,
0.01839004084467888,
0.13207590579986572,
-0.6831148862838745,
0.2792823016643524,
-0.2351858913898468,
-0.514548122882843,
0.12017054110765457,
0.025498969480395317,
-0.39354628324508667,
0.09211167693138123,
-0.06267564743757248,
-0.14677537977695465,
-0.035949643701314926,
-0.1619761735200882
] |
BACKGROUND: On June 11, 2009, the World Health Organization declared phase 6 of the novel influenza A/H1N1 pandemic. Although by the end of September 2009, the novel virus had been reported from all continents, the impact in most countries of the northern hemisphere has been limited. The return of the virus in a second wave would encounter populations that are still nonimmune and not vaccinated yet. We modelled the effect of control strategies to reduce the spread with the goal to defer the epidemic wave in a country where it is detected in a very early stage. METHODOLOGY/PRINCIPAL FINDINGS: We constructed a deterministic SEIR model using the age distribution and size of the population of Germany based on the observed number of imported cases and the early findings for the epidemiologic characteristics described by Fraser (Science, 2009). We propose a two-step control strategy with an initial effort to trace, quarantine, and selectively give prophylactic treatment to contacts of the first 100 to 500 cases. In the second step, the same measures are focused on the households of the next 5,000 to 10,000 cases. As a result, the peak of the epidemic could be delayed up to 7.6 weeks if up to 30% of cases are detected. However, the cumulative attack rates would not change. Necessary doses of antivirals would be less than the number of treatment courses for 0.1% of the population. In a sensitivity analysis, both case detection rate and the variation of R0 have major effects on the resulting delay. CONCLUSIONS/SIGNIFICANCE: Control strategies that reduce the spread of the disease during the early phase of a pandemic wave may lead to a substantial delay of the epidemic. Since prophylactic treatment is only offered to the contacts of the first 10,000 cases, the amount of antivirals needed is still very limited. | [
-0.009603042155504227,
0.02321133017539978,
-0.007289791479706764,
0.01848490908741951,
0.025518538430333138,
0.010343669913709164,
0.008535031229257584,
0.011368357576429844,
-0.017613761126995087,
-0.032510414719581604,
-0.0022082231007516384,
0.02168918028473854,
-0.01740330643951893,
-0.011762874200940132,
0.0100583890452981,
0.018704790621995926,
-0.004882047884166241,
0.009353108704090118,
0.01732718013226986,
0.005927250254899263,
-0.007898668758571148,
0.01717323064804077,
0.011365793645381927,
0.020506519824266434,
0.020154032856225967,
-0.006358347833156586,
-0.0026056417264044285,
-0.028369968757033348,
-0.007351221516728401,
0.015541601926088333,
0.006762715056538582,
0.020514514297246933,
0.0035219755955040455,
0.004766902886331081,
-0.007900392636656761,
0.03170875087380409,
-0.0027153389528393745,
0.02204057015478611,
-0.026377733796834946,
-0.003119487315416336,
0.009311273694038391,
-0.01919316127896309,
0.009560441598296165,
0.00537369679659605,
-0.008782693184912205,
0.03906027972698212,
-0.010895274579524994,
-0.005615411791950464,
-0.018912095576524734,
0.004828090779483318,
0.007567765191197395,
0.009501257911324501,
-0.017673373222351074,
0.016626253724098206,
-0.006847052369266748,
0.02309885434806347,
0.020755404606461525,
0.019796498119831085,
-0.02538422681391239,
0.02093793824315071,
0.02853897213935852,
0.0214497409760952,
0.0019753938540816307,
0.0034568472765386105,
-0.006531283259391785,
-0.06673926115036011,
-0.0016388697549700737,
0.005118552129715681,
-0.0005237238947302103,
0.0023470071610063314,
-0.01370360516011715,
0.00718104699626565,
-0.02065451443195343,
-0.018236488103866577,
-0.05109983682632446,
-0.004711451008915901,
0.018653038889169693,
0.011747846379876137,
-0.006421511992812157,
-0.008175671100616455,
0.0032572930213063955,
-0.003179276827722788,
0.006570994388312101,
0.008547074161469936,
-0.018213553354144096,
0.005369515158236027,
-0.020404955372214317,
0.01821070909500122,
0.009352846071124077,
-0.01008435245603323,
0.01488401647657156,
-0.0053845178335905075,
-0.050109729170799255,
-0.0125675518065691,
-0.006979647092521191,
-0.0260943491011858,
0.0028324155136942863,
0.009694176726043224,
-0.003940277732908726,
-0.030116986483335495,
0.019034864380955696,
0.011353212408721447,
0.012491773813962936,
0.009967721998691559,
-0.01389285922050476,
0.009102951735258102,
-0.015717726200819016,
0.007853804156184196,
-0.010333824902772903,
-0.0036120289005339146,
-0.0023619760759174824,
-0.0017126575112342834,
0.005829290486872196,
0.010716349817812443,
-0.016105862334370613,
0.01103932037949562,
-0.0016417994629591703,
0.02074170671403408,
0.0010334770195186138,
0.0249067023396492,
-0.0003995129372924566,
-0.027940144762396812,
0.009804081171751022,
0.0004212188068777323,
-0.005748060531914234,
-0.0014525118749588728,
-0.017032204195857048,
0.004447385668754578,
-0.010819228366017342,
-0.006344408728182316,
-0.007010300178080797,
-0.005295817740261555,
-0.007864722050726414,
-0.01836191490292549,
-0.006497237365692854,
0.001632471103221178,
-0.003261747770011425,
0.02091127447783947,
-0.015452521853148937,
0.012851417064666748,
-0.00391132989898324,
0.014695743098855019,
-0.010051524266600609,
0.015581449493765831,
0.027490513399243355,
0.0062105972319841385,
0.001248410902917385,
0.01187130156904459,
0.02736671268939972,
-0.012659592553973198,
0.01065104641020298,
0.011171452701091766,
-0.003248166060075164,
-0.011354479938745499,
-0.020430458709597588,
0.018177498131990433,
-0.008166790008544922,
-0.019167017191648483,
-0.00753819802775979,
0.016034727916121483,
0.006327649112790823,
-0.0013574392069131136,
-0.02411622926592827,
0.008995553478598595,
0.013389457017183304,
0.0018429695628583431,
0.01861593686044216,
-0.0007268769550137222,
-0.00941296573728323,
0.00447292672470212,
0.003494713921099901,
0.01520924735814333,
-0.0004891203716397285,
0.011671971529722214,
0.02148265764117241,
-0.025537967681884766,
0.0049402667209506035,
0.007142344955354929,
0.008818850852549076,
0.06618189811706543,
-0.0075869373977184296,
-0.022497210651636124,
-0.012073779478669167,
0.021159552037715912,
-0.009269297122955322,
-0.003069619880989194,
0.03517099469900131,
0.00012734625488519669,
-0.001676423940807581,
0.00541338138282299,
-0.011643417179584503,
-0.018616389483213425,
0.007007972337305546,
-0.026887929067015648,
-0.013078675605356693,
0.0035552605986595154,
0.014337204396724701,
0.006219148635864258,
-0.0041443537920713425,
0.008529165759682655,
0.01006249524652958,
-0.01227376889437437,
0.03682565689086914,
0.0019638848025351763,
-0.02049938589334488,
0.016420036554336548,
0.014442367479205132,
-0.0014396470505744219,
0.005460155196487904,
-0.020298819988965988,
0.01789785549044609,
-0.03793203458189964,
-0.013087349943816662,
-0.004946866538375616,
-0.018745938315987587,
-0.00293926103040576,
0.014779580757021904,
0.008753173053264618,
-0.0004825838841497898,
-0.017288001254200935,
0.0015302036190405488,
0.0051183574832975864,
-0.03248520940542221,
0.007652430795133114,
-0.0015815217047929764,
0.009892355650663376,
-0.006442131940275431,
0.012052061036229134,
0.019662877544760704,
0.004860967397689819,
-0.025962332263588905,
-0.01071924902498722,
-0.009808498434722424,
-0.01920846663415432,
0.0002854634076356888,
0.008074446581304073,
0.011145936325192451,
-0.02318316325545311,
0.006033079698681831,
-0.01210892666131258,
-0.00023263576440513134,
-0.027822889387607574,
0.01754813641309738,
-0.01801786571741104,
0.02609829232096672,
0.003322418313473463,
0.039686743170022964,
-0.005129517056047916,
-0.03202105313539505,
0.01486443541944027,
0.007100152783095837,
-0.007563644554466009,
0.028994128108024597,
0.019402749836444855,
0.004193061962723732,
-0.019809182733297348,
0.017317388206720352,
0.008685408160090446,
0.025098435580730438,
0.01122249849140644,
0.0181166660040617,
0.00459376210346818,
-0.020479032769799232,
-0.013767555356025696,
0.007675393018871546,
0.011513394303619862,
0.011752113699913025,
-0.004175083711743355,
0.011481923051178455,
0.012752298265695572,
0.005092143546789885,
-0.012141321785748005,
0.005861072801053524,
-0.08170953392982483,
-0.00831117294728756,
0.008467424660921097,
0.007995379157364368,
0.009791569784283638,
-0.009636973962187767,
0.008221161551773548,
0.014653525315225124,
-0.015827005729079247,
0.02178780920803547,
-0.012389970012009144,
0.02445143461227417,
-0.0010324621107429266,
-0.013671809807419777,
-0.022656694054603577,
0.000040040031308308244,
0.008527426049113274,
0.008551036939024925,
-0.02957272343337536,
0.01242808997631073,
-0.008484378457069397,
0.003969140816479921,
0.03649437054991722,
-0.017551492899656296,
-0.0028049324173480272,
0.0028921812772750854,
0.016113024204969406,
-0.0038595148362219334,
0.019331563264131546,
0.016766637563705444,
0.001294206827878952,
-0.03567780554294586,
-0.011013619601726532,
-0.013245927169919014,
0.018000982701778412,
0.011791016906499863,
0.008125719614326954,
-0.01605948805809021,
-0.01596469059586525,
-0.003079039976000786,
0.013394509442150593,
0.003652272978797555,
0.007893649861216545,
-0.004697238095104694,
-0.0007877158932387829,
-0.0136175025254488,
0.012116363272070885,
0.00377427670173347,
0.01926306262612343,
0.01911742053925991,
-0.0003424696624279022,
-0.016315776854753494,
0.03084893524646759,
0.016546085476875305,
-0.005902979522943497,
0.011269878596067429,
-0.02585967816412449,
-0.029590679332613945,
-0.009816579520702362,
0.004962665028870106,
-0.015382641926407814,
0.02648017928004265,
0.007240107748657465,
0.00023126229643821716,
-0.029470402747392654,
-0.012031562626361847,
0.006923007778823376,
-0.004845592193305492,
-0.00961651187390089,
0.01186458207666874,
-0.0045738848857581615,
-0.0031669088639318943,
0.023541545495390892,
-0.011895538307726383,
-0.012834827415645123,
-0.0003420010325498879,
-0.01142565906047821,
-0.011692453175783157,
-0.011565342545509338,
-0.004887832794338465,
-0.016411414369940758,
0.012590382248163223,
-0.009821482002735138,
-0.00742292171344161,
0.0009528999216854572,
-0.010664710775017738,
0.022315211594104767,
-0.019011152908205986,
0.02112392708659172,
-0.016776952892541885,
0.016527801752090454,
0.02298593521118164,
-0.020298849791288376,
0.013772279024124146,
-0.004800647497177124,
-0.010654455050826073,
0.01344336662441492,
0.009722666814923286,
0.013421163894236088,
0.00822770781815052,
0.0033951345831155777,
-0.0214735995978117,
0.013341078534722328,
-0.010313458740711212,
-0.021796388551592827,
0.014686735346913338,
0.0034002233296632767,
-0.029754025861620903,
-0.008226482197642326,
-0.011939261108636856,
0.015264992602169514,
-0.0009038439020514488,
0.0031332792714238167,
-0.010203998535871506,
0.011874103918671608,
-0.010817980393767357,
0.031617019325494766,
0.004943126812577248,
0.07193148136138916,
-0.007025763392448425,
-0.000051561626605689526,
-0.01805339939892292,
0.047314904630184174,
-0.016919579356908798,
0.02668769657611847,
0.004240565001964569,
-0.0101626543328166,
-0.017163816839456558,
0.013663788326084614,
-0.03648743778467178,
0.00356797082349658,
-0.005036383401602507,
0.0018752836622297764,
-0.018966253846883774,
0.0037359215784817934,
-0.012088780291378498,
0.04140402376651764,
-0.01668998785316944,
0.00979701243340969,
0.00016326457262039185,
0.006646463647484779,
-0.007753456011414528,
0.014682061970233917,
0.014522920362651348,
-0.00001753563992679119,
-0.011381102725863457,
-0.002091530943289399,
0.0010555885965004563,
-0.011985201388597488,
-0.012686774134635925,
-0.006070269737392664,
-0.015765568241477013,
0.002190764294937253,
0.000939368037506938,
-0.0054398151114583015,
-0.020202046260237694,
0.005173135083168745,
-0.011189602315425873,
-0.007981815375387669,
-0.013273488730192184,
-0.005823688581585884,
0.014995216391980648,
-0.01368146575987339,
0.009668843820691109,
-0.010953113436698914,
-0.0006235783221200109,
-0.02213796228170395,
0.015838850289583206,
-0.007967852056026459,
-0.0029885745607316494,
0.01385204866528511,
-0.0055874064564704895,
0.011493201367557049,
-0.0026024659164249897,
0.014530736953020096,
-0.0034616917837411165,
0.01425404567271471,
-0.009477809071540833,
-0.011152336373925209,
-0.031055599451065063,
0.008184717036783695,
-0.011439017951488495,
-0.0010530645959079266,
-0.013910658657550812,
-0.02822546474635601,
0.009786151349544525,
-0.0226982943713665,
0.0067739179357886314,
-0.03341810405254364,
-0.008166203275322914,
0.008765161968767643,
-0.013469183817505836,
-0.0428948774933815,
-0.003449397161602974,
-0.05113916099071503,
0.025103453546762466,
-0.011215360835194588,
0.015073408372700214,
-0.015882765874266624,
-0.020572613924741745,
0.02411101572215557,
0.004048245958983898,
0.0006332306656986475,
-0.00029891589656472206,
-0.007054653484374285,
-0.07426682859659195,
-0.031820040196180344,
0.001727227121591568,
-0.009487182833254337,
0.010036232881247997,
0.008731650188565254,
-0.024692704901099205,
0.01229432038962841,
-0.028341688215732574,
-0.007464345078915358,
-0.011965308338403702,
0.021281773224473,
0.019000956788659096,
-0.003637698944658041,
0.017885861918330193,
-0.004823743365705013,
-0.010507658123970032,
-0.003989613614976406,
-0.019683877006173134,
-0.0014706316869705915,
0.024962730705738068,
-0.009872552007436752,
-0.04067819193005562,
-0.008564312011003494,
0.005629981402307749,
-0.08086174726486206,
-0.0291774719953537,
0.01996799185872078,
-0.01257613766938448,
0.011457682587206364,
-0.011906895786523819,
0.00613580085337162,
-0.03497175872325897,
-0.011555127799510956,
-0.015562182292342186,
0.0051903026178479195,
0.015043848194181919,
0.0031672418117523193,
0.0008951705531217158,
0.009617351926863194,
-0.007242081221193075,
0.012647045776247978,
0.019856425002217293,
0.028833305463194847,
0.0038044704124331474,
0.011214961297810078,
0.012784324586391449,
-0.004943878389894962,
-0.00663039181381464,
-0.015606614761054516,
0.0015559620223939419,
-0.004566792398691177,
0.007386890240013599,
0.0172821506857872,
-0.022768795490264893,
-0.019609708338975906,
0.001625213772058487,
0.018524840474128723,
0.025678342208266258,
0.02717539295554161,
-0.003364542033523321,
0.01688675954937935,
-0.016295863315463066,
0.008175570517778397,
-0.011293729767203331,
-0.005159894935786724,
0.014527151361107826,
0.011583651416003704,
0.0057871523313224316,
0.016890358179807663,
-0.010742971673607826,
0.012191698886454105,
-0.010248992592096329,
0.0190043356269598,
0.006989367306232452,
-0.0038973730988800526,
0.0003750985488295555,
0.012835465371608734,
-0.0063096811063587666,
-0.002700925339013338,
0.004723621066659689,
-0.0013636844232678413,
0.011788403615355492,
0.0022281904239207506,
0.008021595887839794,
-0.01167357712984085,
-0.0008414508774876595,
-0.0020319237373769283,
0.07116560637950897,
-0.01111271046102047,
0.003599954303354025,
0.00017122714780271053,
-0.015164526179432869,
-0.002279240870848298,
0.014654476195573807,
0.014505790546536446,
-0.0036094849929213524,
-0.011459005996584892,
0.02452867664396763,
-0.006546834483742714,
-0.021019041538238525,
0.007782158441841602,
-0.000294368714094162,
0.02695612423121929,
0.007367203943431377,
-0.007944483309984207,
-0.016566574573516846,
-0.0027378376107662916,
0.012539472430944443,
-0.0016093221493065357,
-0.009176897816359997,
-0.010389589704573154,
0.037899576127529144,
0.0033952840603888035,
-0.00850101187825203,
0.003629520069807768,
-0.00961395725607872,
-0.000018386635929346085,
-0.006614590995013714,
-0.010598949156701565,
0.007728928234428167,
-0.0015843268483877182,
0.01802615076303482,
0.009215088561177254,
0.020387928932905197,
0.011976834386587143,
0.00857741478830576,
0.01113185565918684,
0.03328254818916321,
-0.012154006399214268,
0.005098638124763966,
-0.007588467560708523,
0.004661047365516424,
-0.03383827954530716,
0.01707036979496479,
0.030114073306322098,
-0.0053736125119030476,
0.005878747440874577,
-0.010780834592878819,
0.009266214445233345,
-0.003801213577389717,
0.00614514434710145,
-0.004793599713593721,
0.01866999641060829,
-0.0031045125797390938,
0.025477653369307518,
0.011304514482617378,
0.006392426788806915,
-0.003488813294097781,
-0.01657910831272602,
-0.00023873569443821907,
-0.013101285323500633,
0.00802023895084858,
-0.02640075795352459,
0.006930100731551647,
-0.018936317414045334,
0.021704182028770447,
0.004926957190036774,
0.0016407351940870285,
0.009270037524402142,
0.0018015627283602953,
-0.0007553736213594675,
0.01445012167096138,
0.011202901601791382,
0.015184956602752209,
0.002134212525561452,
0.006439588498324156,
0.003256495576351881,
-0.011981988325715065,
-0.031726107001304626,
0.0041578589007258415,
-0.006082400679588318,
-0.014741301536560059,
-0.016503142192959785,
-0.010816986672580242,
-0.020367465913295746,
-0.009285496547818184,
0.004818137269467115,
0.0330788791179657,
0.006304200738668442,
0.0027837359812110662,
-0.002393642906099558,
0.011590363457798958,
0.035277023911476135,
0.009652789682149887,
0.0070770662277936935,
0.03757612407207489,
-0.0073987324722111225,
-0.012147000059485435,
-0.014326122589409351,
0.018631301820278168,
-0.013194604776799679,
-0.004740778356790543,
-0.005977804772555828,
0.016934433951973915,
0.001486137043684721,
0.007042971905320883,
0.01673453114926815,
-0.026634298264980316,
-0.004865135066211224,
0.007691279519349337,
-0.007238958962261677,
0.001681698253378272,
0.013747450895607471,
-0.010993555188179016,
0.009007958695292473,
0.008889829739928246,
-0.009142111986875534,
-0.015282792039215565,
-0.009357094764709473,
0.018780339509248734,
0.017285030335187912,
-0.007452842313796282,
-0.008346427232027054,
-0.004968330264091492,
-0.01436395663768053,
-0.011469969525933266,
-0.005063073709607124,
0.013322940096259117,
-0.012105386704206467,
0.008504915051162243,
-0.0005417424254119396,
0.00991978868842125,
0.015467369928956032,
0.0149986632168293,
-0.002495603868737817,
-0.0029944023117423058,
0.00994887575507164,
-0.013317348435521126,
0.003035573288798332,
0.0031449601519852877,
-0.011650948785245419,
0.012271769344806671,
-0.01567085273563862,
0.0031476474832743406,
-0.026264630258083344,
0.013355421833693981,
-0.0076025715097785,
0.016328543424606323,
0.004223973490297794,
0.015262629836797714,
-0.003267449326813221,
0.004670030903071165,
-0.01274908147752285,
0.0076943011954426765,
-0.02303234301507473,
-0.02219231054186821,
-0.006475595757365227,
-0.0038125489372760057,
0.008168220520019531,
0.00711560994386673,
0.012089109979569912,
-0.011925667524337769,
-0.010329125449061394,
0.030397333204746246,
-0.0016990366857498884,
0.007195215206593275,
0.018630145117640495,
-0.00002462277188897133,
0.01111968420445919,
0.01256245095282793,
0.016166524961590767,
0.006409850902855396,
-0.010127805173397064,
0.004943540785461664,
0.02399073913693428,
0.000025891931727528572,
0.014287243597209454,
0.018178533762693405,
0.01586000807583332,
0.006556931883096695,
-0.00980500690639019,
-0.015691375359892845,
0.010957964695990086,
-0.018029063940048218,
0.017006641253829002,
0.017364418134093285,
0.006593940779566765,
-0.02460017055273056,
0.004805614240467548,
-0.009458683431148529,
-0.002452766988426447,
0.0013928544940426946,
-0.01864260621368885,
-0.05504846200346947,
-0.011455420404672623,
0.009477720595896244,
0.012974072247743607,
0.017083391547203064,
0.014752717688679695
] | [
0.5298988223075867,
0.09536580741405487,
0.029259005561470985,
-0.17132800817489624,
0.022268714383244514,
-0.22294294834136963,
0.5292502641677856,
0.34985482692718506,
-0.4813074469566345,
-0.21160461008548737,
-0.18078278005123138,
-0.16853214800357819,
-0.3974830210208893,
0.6418992280960083,
0.14303725957870483,
0.43341130018234253,
0.672487735748291,
0.2754054367542267,
-0.5214723944664001,
-0.24788393080234528,
-0.4537459909915924,
-0.5235710740089417,
0.01288842223584652,
0.5113438367843628,
0.21466675400733948,
-0.33886614441871643,
0.42140206694602966,
-0.052652910351753235,
0.5164988040924072,
0.0275794118642807,
0.11659562587738037,
0.3919889032840729,
0.08773769438266754,
-0.027514420449733734,
-0.19774365425109863,
-0.03402286767959595,
-0.35664236545562744,
0.040964893996715546,
-0.17870837450027466,
-0.2952401638031006,
-0.11817542463541031,
0.04612461477518082,
-0.06971703469753265,
0.3541201651096344,
0.3632891774177551,
-0.33596619963645935,
-1.2586913108825684,
0.4889315962791443,
-0.2726256549358368,
0.34740203619003296,
0.05541299656033516,
0.12176638096570969,
-0.12306690961122513,
0.03369452804327011,
-0.2807212471961975,
0.49892592430114746,
-0.4147203862667084,
0.030696868896484375,
-0.03127342835068703,
-0.6849589943885803,
0.15981976687908173,
-0.4913315176963806,
0.09658874571323395,
0.46261245012283325,
-0.23992909491062164,
0.1671658605337143,
0.33465567231178284,
0.33172667026519775,
0.4708001911640167,
-0.6028137803077698,
0.05988466367125511,
-0.225128635764122,
-0.3267398774623871,
-0.17196974158287048,
-0.06140662357211113,
-0.20890597999095917,
0.19882260262966156,
-0.44910329580307007,
0.5472124814987183,
0.18749971687793732,
-0.365221232175827,
-0.06661510467529297,
0.05622324347496033,
-0.49640294909477234,
0.48145386576652527,
-0.08396338671445847,
0.3593420684337616,
0.493141233921051,
-0.05684896185994148,
-0.036171842366456985,
0.04871236905455589,
-0.22723551094532013,
0.6238582134246826,
0.573189377784729,
0.10248284786939621,
0.24121150374412537,
0.07834847271442413,
-0.5246221423149109,
0.10787469893693924,
-0.4214481711387634,
-0.518233060836792,
0.003908804152160883,
0.002862239023670554,
0.08530592173337936,
-0.31586068868637085,
-0.4047485888004303,
0.10618367046117783,
-0.2904956638813019,
-0.5335354804992676,
0.05320711433887482,
0.08158814907073975,
0.03904174268245697,
0.003907863982021809,
-0.3650698661804199,
-0.41748926043510437,
0.2634182870388031,
0.23751293122768402,
-0.4380280077457428,
0.19513200223445892,
-0.059671785682439804,
0.11445163935422897,
0.685275673866272,
-0.36538153886795044,
0.4444813132286072,
-0.23498080670833588,
-0.19485905766487122,
0.39120393991470337,
0.06406240165233612,
-0.45194828510284424,
0.36234527826309204,
0.0774797573685646,
0.5773374438285828,
-0.32033228874206543,
0.07616463303565979,
0.04069651663303375,
0.19718655943870544,
0.14965617656707764,
0.38653630018234253,
0.0764373317360878,
-0.10714111477136612,
-0.2340095490217209,
-0.5596997141838074,
-0.4728156626224518,
0.2568604350090027,
0.23360055685043335,
-0.3562674820423126,
-0.2409786581993103,
0.06916841864585876,
-0.21714535355567932,
-0.5007784962654114,
0.09581533819437027,
-0.07253357768058777,
-0.4433628022670746,
0.05376352369785309,
-0.09281778335571289,
0.6518563032150269,
-0.19852223992347717,
-0.1577618271112442,
0.10829563438892365,
0.11370152980089188,
0.6808057427406311,
0.3213541507720947,
0.11782580614089966,
-0.12357380241155624,
0.4330277740955353,
0.0742119625210762,
0.18470142781734467,
0.2825212776660919,
-0.10771679133176804,
-0.07454492896795273,
-0.34688299894332886,
-0.24105684459209442,
0.05787054821848869,
-0.6531839966773987,
-0.3600064516067505,
-0.04937662184238434,
0.4725053906440735,
-0.03965543210506439,
0.14185215532779694,
0.46323996782302856,
-0.4281117022037506,
-0.26613155007362366,
-0.05403248220682144,
-0.35907530784606934,
0.2666846215724945,
-0.08148496598005295,
0.1297377049922943,
0.16447599232196808,
0.14424408972263336,
0.08171408623456955,
-0.3498225808143616,
-0.6140263080596924,
0.5283725261688232,
-0.633850634098053,
1.3115315437316895,
-0.39976009726524353,
-0.05584824085235596,
1.5391263961791992,
0.05561138316988945,
0.39478978514671326,
0.03969878703355789,
0.42919012904167175,
0.8587002158164978,
-0.0795087218284607,
-0.708543062210083,
0.14906039834022522,
0.1189083456993103,
-0.10725840926170349,
-0.2546573579311371,
-0.12822028994560242,
0.08744722604751587,
-0.11172764003276825,
-0.1339952051639557,
0.08011201024055481,
0.38842615485191345,
0.3210816979408264,
-0.3779427111148834,
-0.09104248881340027,
0.08978630602359772,
-0.25186625123023987,
-0.16404077410697937,
-0.5630327463150024,
-0.009120510891079903,
-0.09255800396203995,
0.2666122317314148,
0.6224280595779419,
0.4968174993991852,
-0.09637847542762756,
0.8311081528663635,
-0.5676518082618713,
-0.06786948442459106,
0.23328633606433868,
0.2787773013114929,
-0.6970662474632263,
-0.5347385406494141,
-0.12444809824228287,
0.09195848554372787,
0.1183263435959816,
-0.3991129696369171,
0.1311880201101303,
0.46227577328681946,
-0.007113638333976269,
-0.4420904517173767,
0.16356447339057922,
-0.12256771326065063,
-0.018000010401010513,
0.2244923710823059,
-0.1615111380815506,
-0.4140615165233612,
0.061968978494405746,
0.3365894556045532,
0.4501996338367462,
0.2519133985042572,
-0.46874186396598816,
0.30746200680732727,
0.1401894986629486,
0.061172354966402054,
-0.2929624915122986,
0.4337632358074188,
-0.25068002939224243,
0.32149961590766907,
-0.12830215692520142,
-0.08272349834442139,
-0.07570740580558777,
0.5042152404785156,
-0.7861900925636292,
-0.6402467489242554,
-0.599717378616333,
0.5918101072311401,
0.08334826678037643,
0.6070424914360046,
-0.21569716930389404,
-0.4721173346042633,
0.2851252853870392,
0.26865971088409424,
-0.6960182189941406,
0.35762664675712585,
0.6696833968162537,
-0.4222625494003296,
-0.3265821039676666,
-0.24906082451343536,
0.3395005762577057,
0.44272565841674805,
-0.3772580325603485,
-0.05794193595647812,
-0.21197234094142914,
-0.0118525056168437,
-0.2743816673755646,
-0.18886850774288177,
0.16369226574897766,
-0.007546435575932264,
0.10360535979270935,
-0.07849889993667603,
-0.243398517370224,
0.052642788738012314,
0.0923938900232315,
-0.3696345388889313,
0.25076478719711304,
0.46175616979599,
-0.11537878960371017,
-0.25837862491607666,
0.06596693396568298,
-0.014186009764671326,
-0.38527265191078186,
-0.16946528851985931,
0.12590710818767548,
-0.35364478826522827,
-0.18163245916366577,
-6.269183158874512,
0.18568837642669678,
-0.058194298297166824,
-0.40340253710746765,
-0.5795710682868958,
0.39069071412086487,
0.6151420474052429,
0.49831950664520264,
0.43071624636650085,
-0.32661375403404236,
0.3056323528289795,
0.19370704889297485,
0.05034869164228439,
0.26132529973983765,
-0.09348083287477493,
0.20147225260734558,
-0.09663655608892441,
-0.25424957275390625,
0.014785620383918285,
0.32661789655685425,
-0.09068243950605392,
-0.024975309148430824,
-0.0514298751950264,
0.066414013504982,
0.4477253556251526,
0.42201778292655945,
-0.6466163396835327,
0.5241155624389648,
0.020520169287919998,
0.20988470315933228,
0.40156829357147217,
-0.6832072138786316,
-0.18055550754070282,
0.14303447306156158,
-0.38828882575035095,
0.20863378047943115,
-0.10583113133907318,
-0.5242626667022705,
-0.2588137090206146,
-0.11974920332431793,
0.22661933302879333,
0.21308165788650513,
-0.32767927646636963,
-0.35471969842910767,
0.15160594880580902,
-0.20705045759677887,
-0.04334716498851776,
0.12053398787975311,
-0.1407388150691986,
0.737986147403717,
0.16999420523643494,
-0.05851975828409195,
-0.28263014554977417,
0.39345070719718933,
0.08549036085605621,
-0.103144571185112,
-0.12737153470516205,
-0.007517726626247168,
-0.315102756023407,
-0.159398153424263,
0.25054630637168884,
-0.08798791468143463,
0.46098431944847107,
-0.504753589630127,
0.3212329149246216,
0.18484731018543243,
-0.9950650930404663,
-0.5432230234146118,
-0.14205025136470795,
0.03633289411664009,
-0.17238090932369232,
0.16174781322479248,
0.0956178531050682,
-0.6100621819496155,
-0.6893523335456848,
-0.6143984794616699,
-0.10348490625619888,
-0.1091049462556839,
0.2999752163887024,
-0.4574224650859833,
-0.4048891067504883,
-0.24049295485019684,
0.23445779085159302,
-0.4143587052822113,
0.04499621316790581,
-0.06729700416326523,
0.15477769076824188,
0.017547082155942917,
-0.07813906669616699,
0.24698542058467865,
0.8942098021507263,
-0.649553120136261,
0.0035683540627360344,
0.20004135370254517,
0.23620451986789703,
0.9577801823616028,
0.11533532291650772,
-0.1997300386428833,
0.31848078966140747,
0.21258866786956787,
0.33870118856430054,
-0.2662162184715271,
-0.24654462933540344,
-0.7048181295394897,
0.024290041998028755,
-0.10466089844703674,
-0.37937626242637634,
0.22714218497276306,
0.5601043105125427,
-0.22213603556156158,
0.09227745980024338,
0.06657903641462326,
-0.3494505286216736,
-0.13989795744419098,
0.7136355042457581,
-0.24817219376564026,
0.5592066645622253,
0.26439985632896423,
0.6434533596038818,
-0.3810271918773651,
0.3887134790420532,
0.27427974343299866,
-0.0063406117260456085,
0.7135992050170898,
0.37602925300598145,
-0.2605341076850891,
0.046535033732652664,
0.33277156949043274,
-0.04904477298259735,
-0.24135439097881317,
0.3166542649269104,
0.3045746386051178,
0.16998456418514252,
-0.39621275663375854,
0.5382987856864929,
-0.24325796961784363,
-0.41543805599212646,
-0.16522802412509918,
0.1877705454826355,
0.0989217534661293,
-0.3921274244785309,
0.2130403369665146,
-0.4744300842285156,
0.0684637725353241,
-0.019250541925430298,
-0.22986482083797455,
0.06031462550163269,
0.003331210929900408,
0.030395017936825752,
-0.2733592391014099,
0.1782059222459793,
0.27791428565979004,
0.13087238371372223,
0.05094289034605026,
-0.98903489112854,
-0.1156395897269249,
0.8369476199150085,
-0.16907182335853577,
-0.10770629346370697,
-0.40965819358825684,
0.31064316630363464,
0.1401643306016922,
-0.9339795112609863,
0.03709288686513901,
0.17017973959445953,
-0.6693547368049622,
0.4683802127838135,
-0.5715578198432922,
0.04355582967400551,
0.10247063636779785,
-0.017946049571037292,
-0.578658401966095,
-0.17459097504615784,
0.06758563965559006,
0.21864229440689087,
0.1374896913766861,
-0.38732773065567017,
-0.272145539522171,
0.10095154494047165,
0.4069026708602905,
0.2667344808578491,
-0.6203741431236267,
-0.629233717918396,
0.44945165514945984,
0.6387022137641907,
0.607865035533905,
-0.2319382131099701,
-0.4298470616340637,
-0.22259269654750824,
-0.21922196447849274,
0.3814520537853241,
0.23458947241306305,
-0.08760809898376465,
0.26941370964050293,
-0.06898719817399979,
-0.09109698981046677,
-0.25448939204216003,
0.07485493272542953,
0.07799991965293884,
0.017056206241250038,
-0.22782166302204132,
0.47698071599006653,
-0.2990287244319916,
0.07097754627466202,
0.39360132813453674,
-0.3689296841621399,
0.0267031267285347,
-0.05823371931910515,
0.007262522354722023,
-0.2163851112127304,
-0.03710181266069412,
-0.0837399810552597,
-0.19086818397045135,
0.5963737368583679,
-0.18222211301326752,
0.3316420912742615,
-0.07901410013437271,
-0.17452935874462128,
-0.25107866525650024,
0.49989140033721924,
0.07852701842784882,
0.27964502573013306,
-0.171124666929245,
-0.23096731305122375,
-0.051427487283945084,
0.5809223651885986,
0.5770998597145081,
-0.6863382458686829,
-0.09023889154195786,
0.15511243045330048,
-0.2047099620103836,
-0.020876022055745125,
0.2639090120792389,
0.2765584886074066,
-0.5215830206871033,
0.0828866958618164,
0.2416376918554306,
-0.2850693464279175,
0.145346000790596,
0.6278903484344482,
0.19782079756259918,
0.17949967086315155,
0.11473298072814941,
-0.4601747691631317,
-0.114791639149189,
-0.2175028771162033,
-0.14410756528377533,
-0.37771129608154297,
0.19268767535686493,
0.0087322061881423,
-0.2210828959941864,
-0.3871710002422333,
0.13735128939151764,
-0.21446429193019867,
0.31189149618148804,
0.30725786089897156,
-0.04916323721408844,
-0.1870708167552948,
-0.11445287615060806,
-0.1408742368221283,
0.010916565544903278,
-0.4565492868423462,
-0.25636017322540283,
-0.10081525892019272,
0.33235102891921997,
-0.14655564725399017,
-0.36111980676651,
-0.10165520757436752,
0.004861458204686642,
-0.06250429898500443,
0.10337932407855988,
0.2793445885181427,
0.30275118350982666,
0.3337121605873108,
0.22653989493846893,
-0.02345326542854309,
-0.19579270482063293,
-0.033846501260995865,
-0.2883443236351013,
0.3326718509197235,
-0.5564844012260437,
-0.5886450409889221,
0.2380295693874359,
-0.17154893279075623,
0.11101629585027695,
-0.5659295320510864,
0.23220255970954895,
0.016314977779984474,
0.16170088946819305,
-0.7052798271179199,
-0.016497986391186714,
0.02253599464893341,
-0.3841306269168854,
-0.642012894153595,
-0.1902981847524643,
0.03269295021891594,
-0.15655001997947693,
0.5083789825439453,
0.5244665145874023,
-0.5040643811225891,
-0.6047038435935974,
0.6414257884025574,
0.07085685431957245,
-0.5383015275001526,
0.2543172836303711,
-0.045106031000614166,
0.30171501636505127,
0.6062890291213989,
-0.1931917518377304,
0.4965420663356781,
0.3988007605075836,
0.10098348557949066,
0.052312709391117096,
0.49205905199050903,
-0.921091616153717,
0.311622679233551,
-0.2228829562664032,
-0.37328630685806274,
0.42766085267066956,
-0.19611532986164093,
0.07614457607269287,
0.9459121227264404,
0.14833925664424896,
-0.09438075870275497,
-0.4813292920589447,
0.5654950141906738,
-0.20436719059944153,
0.532917857170105,
-0.07540442794561386,
0.23994725942611694,
0.4744935929775238,
0.5242369771003723,
-0.03952547907829285,
0.16250815987586975,
-0.18124087154865265,
0.26235127449035645,
0.19291682541370392,
-0.635430097579956,
0.012400862760841846,
-0.18253949284553528,
0.847807765007019,
-0.04642162099480629,
0.007350562140345573,
-0.15456824004650116,
-0.29371902346611023,
0.08093637973070145,
-0.2093687355518341,
0.05525574833154678,
0.3803197741508484,
0.22583168745040894,
0.4024312496185303,
-0.07608022540807724,
0.026077069342136383,
0.22526808083057404,
-0.042391300201416016,
-0.17675910890102386,
0.2178627848625183,
0.1382090151309967,
-0.6867851614952087,
-0.3201705813407898,
0.40633612871170044,
0.5017980933189392,
-0.019949570298194885,
0.3762926459312439,
0.14969849586486816,
0.08812449127435684,
0.7114174962043762,
0.10684499889612198,
0.025990884751081467,
-0.46823546290397644,
-0.10670531541109085,
-0.3082333207130432,
-0.23082545399665833,
0.3531809151172638,
0.25048062205314636,
-0.36955979466438293,
-0.013955707661807537,
-0.15618856251239777,
-0.03387708589434624,
0.47224316000938416,
-0.32334932684898376,
-0.1274075210094452,
-0.3553335964679718,
-0.24805700778961182,
-0.21286246180534363,
-0.2769881784915924,
0.026418421417474747,
0.16801905632019043,
0.2082328051328659,
-0.06433285027742386,
-0.07796049863100052,
-0.7110379338264465,
-0.08716527372598648,
0.21056698262691498,
0.024881597608327866,
-0.16468776762485504,
-0.02388141304254532,
0.5964759588241577,
0.1457756906747818,
0.33878618478775024,
0.13088874518871307,
-0.2099515050649643,
-0.20036236941814423,
0.7418501377105713,
-0.25625577569007874,
0.21889621019363403,
-0.25780779123306274,
-0.2791067361831665,
-0.6188673377037048,
-0.05165454372763634,
0.48303645849227905,
0.09612588584423065,
-0.39380574226379395,
0.19215956330299377,
0.06044928357005119,
0.08917108923196793,
0.3164166510105133,
-0.04794833064079285,
-0.06716037541627884,
-0.5228562355041504,
-0.2332020103931427,
-0.576153039932251,
-0.2069559246301651,
0.07659213244915009,
-0.026829883456230164,
-0.06702878326177597,
0.33555373549461365,
0.637938916683197,
0.007146287709474564,
0.7228378057479858,
0.002647739602252841,
-0.08948197215795517,
-0.3542234003543854,
0.3030898869037628,
-0.5212650895118713,
0.0409880131483078,
0.49547818303108215,
0.10863855481147766,
0.09871220588684082,
-0.13327525556087494,
-0.11594325304031372,
-0.2589091956615448,
0.4426148235797882,
-0.02802407741546631,
0.13694347441196442,
0.10727594047784805,
-0.04150284826755524,
0.07248502969741821,
-0.4597305953502655,
0.3442678153514862,
-0.2752917408943176,
0.2567981779575348,
-0.13220743834972382,
-0.13775771856307983,
0.10131946951150894,
0.069376640021801,
-0.09730714559555054,
-0.4008725881576538,
0.04160495102405548,
-0.4100542366504669
] |
[
0.030699975788593292,
0.10140369832515717,
-0.04192632809281349,
0.06293141841888428,
-0.03267847001552582,
-0.12038351595401764,
0.035765983164310455,
-0.05915536358952522,
-0.008488839492201805,
-0.05911063775420189,
-0.05657084658741951,
-0.005575065966695547,
-0.05070307105779648,
0.06654473394155502,
-0.05232572928071022,
-0.10524960607290268,
-0.11025319993495941,
0.10980250686407089,
0.11460278183221817,
-0.11366231739521027,
-0.0736834928393364,
-0.014200853183865547,
0.03315950185060501,
-0.042415086179971695,
-0.18886972963809967,
0.04834016412496567,
-0.010257190093398094,
-0.013155662454664707,
-0.11621294915676117,
0.22128282487392426,
0.026432644575834274,
-0.0035340951289981604,
0.09944672882556915,
0.0506606251001358,
0.07618589699268341,
-0.1337132453918457,
-0.07806193083524704,
0.018981769680976868,
-0.056862808763980865,
-0.14643901586532593,
-0.16388945281505585,
-0.057634275406599045,
0.07937344908714294,
-0.0544847771525383,
-0.024052107706665993,
-0.07310523092746735,
-0.07155387103557587,
-0.10090649873018265,
-0.028452187776565552,
0.14460046589374542,
-0.05908972769975662,
-0.0028850892558693886,
-0.030829090625047684,
-0.06325825303792953,
-0.02312028780579567,
-0.15990810096263885,
-0.09092682600021362,
-0.016466086730360985,
0.06645786762237549,
0.04531364515423775,
-0.11512433737516403,
0.10278821736574173,
-0.23874814808368683,
-0.08993463963270187,
0.04214683547616005,
-0.06208702549338341,
0.19159553945064545,
0.06058281660079956,
0.04147198423743248,
0.04145164415240288,
0.08241380751132965,
0.07910601049661636,
-0.21460114419460297,
-0.04764945060014725,
-0.06004532054066658,
-0.05771621689200401,
0.04311008378863335,
0.029352186247706413,
-0.007787349633872509,
0.0667465552687645,
0.11730451881885529,
-0.036040034145116806,
0.0379948653280735,
0.08618149906396866,
0.09119251370429993,
-0.12663358449935913,
-0.027850864455103874,
-0.026794370263814926,
0.10444615036249161,
-0.19966867566108704,
-0.06711355596780777,
0.020024478435516357,
0.02054487355053425,
-0.07212473452091217,
-0.12159039080142975,
-0.23648804426193237,
-0.04011392965912819,
0.10453135520219803,
-0.08162038028240204,
-0.047898195683956146,
-0.14109919965267181,
-0.09871640801429749,
0.006453124340623617,
0.08454540371894836,
-0.20008768141269684,
0.031001994386315346,
0.3166082501411438,
-0.08357764780521393,
-0.06154737249016762,
0.05468873679637909,
-0.10438451170921326,
-0.043026577681303024,
0.039880186319351196,
-0.002967559266835451,
0.04125188663601875,
0.10730873048305511,
-0.031131744384765625,
0.07599066942930222,
0.11015765368938446,
0.2026078850030899,
0.0340835340321064,
-0.11498764902353287,
0.00341621832922101,
0.1823115050792694,
0.08721653372049332,
0.08886470645666122,
0.038886621594429016,
-0.14626866579055786,
-0.10826382040977478,
-0.10755138099193573,
-0.043079130351543427,
0.06791600584983826,
-0.08626728504896164,
-0.13008858263492584,
-0.06684456765651703,
-0.0757908821105957,
-0.12930254638195038,
0.10704216361045837,
-0.16803321242332458,
0.12600107491016388,
-0.04051733389496803,
0.056915540248155594,
0.09876076132059097,
0.05756385996937752,
0.12005363404750824,
-0.09532523900270462,
-0.0735682025551796,
0.04351639747619629,
0.12305520474910736,
-0.12239664793014526,
-0.03981996327638626,
-0.02161284163594246,
-0.10828825831413269,
-0.0646689310669899,
-0.03846750035881996,
0.19904725253582,
-0.03407208248972893,
-0.10436071455478668,
0.018596051260828972,
0.10414863377809525,
0.09536723792552948,
-0.014020226895809174,
0.04361536353826523,
0.028888408094644547,
-0.06593406200408936,
0.008343683555722237,
0.04160940647125244,
-0.011753213591873646,
-0.11578797549009323,
0.05167029798030853,
-0.06676144897937775,
0.1441592276096344,
-0.22843779623508453,
0.12496988475322723,
0.028016896918416023,
-0.05906530097126961,
0.17457708716392517,
0.05070481076836586,
-0.11385047435760498,
0.060045935213565826,
-0.09621882438659668,
0.05438654124736786,
0.03432608023285866,
0.15427951514720917,
0.11706224828958511,
-0.002386678010225296,
0.00803310889750719,
-0.07359828799962997,
0.15835100412368774,
0.017626335844397545,
-0.007624693680554628,
-0.04966338351368904,
-0.04089459404349327,
0.07255762070417404,
0.21151596307754517,
0.06603258103132248,
0.09396278113126755,
-0.018833069130778313,
0.02596215531229973,
0.07787297666072845,
0.0033172147814184427,
-0.03406890109181404,
-0.0378173291683197,
0.0016285512829199433,
0.17468418180942535,
0.14436595141887665,
0.07670074701309204,
-0.018170222640037537,
-0.12715241312980652,
0.011177051812410355,
0.04855913668870926,
0.05172306299209595,
-0.04483100771903992,
-0.031188545748591423,
0.21232262253761292,
-0.12014889717102051,
0.04454215243458748,
-0.006694146431982517,
-0.008590037934482098,
0.010534912347793579,
-0.005982778966426849,
-0.049038566648960114,
-0.03788432478904724,
-0.148992121219635,
-0.15680280327796936,
0.11952607333660126,
-0.03443474322557449,
-0.009466748684644699,
-0.17385894060134888,
0.06695250421762466,
-0.08063670247793198,
0.1111515536904335,
-0.05964672192931175,
-0.08919277042150497,
0.07400178909301758,
-0.08179539442062378,
0.010917145758867264,
-0.10002771019935608,
0.030084840953350067,
-0.05879339575767517,
0.15256229043006897,
-0.0588756687939167,
0.058464743196964264,
-0.06250129640102386,
-0.1272299885749817,
0.14816193282604218,
0.11261296272277832,
-0.20878300070762634,
0.07267408818006516,
-0.19025585055351257,
0.04558248072862625,
-0.06399069726467133,
0.09287825971841812,
-0.14967121183872223,
0.0832153856754303,
0.0884755551815033,
-0.07130222767591476,
-0.08636317402124405,
-0.062446922063827515,
-0.0917036235332489,
0.04213356599211693,
0.02685438096523285,
-0.07510712742805481,
0.14564858376979828,
-0.1311965137720108,
0.06008942797780037,
0.10980391502380371,
0.23106127977371216,
0.06301818042993546,
-0.11306808888912201,
0.4958252012729645,
-0.08599810302257538,
-0.10827255249023438,
-0.07431084662675858,
0.00557404151186347,
-0.010929758660495281,
0.19725823402404785,
0.07282532006502151,
0.12956568598747253,
0.12012496590614319,
-0.32143303751945496,
-0.003951505292207003,
0.031411223113536835,
0.2858768403530121,
0.007240592502057552,
-0.04573579132556915,
-0.15110504627227783,
-0.06919705122709274,
-0.05780123919248581,
0.045537661761045456,
0.08062059432268143,
0.05595998466014862,
-0.19111478328704834,
0.20023339986801147,
0.030304836109280586,
0.16707292199134827,
-0.019236214458942413,
0.14964352548122406,
-0.0109718581661582,
0.08966008573770523,
-0.1306983232498169,
-0.10273553431034088,
0.05057602375745773,
-0.10228367894887924,
-0.014037727378308773,
0.01175781711935997,
-0.19365377724170685,
0.07810384780168533,
-0.09055490046739578,
-0.024642886593937874,
-0.007601541467010975,
0.024362703785300255,
0.1254616379737854,
-0.048288214951753616,
0.038688793778419495,
-0.023422805592417717,
-0.039048850536346436,
0.09871713072061539,
-0.12935157120227814,
-0.08097562938928604,
-0.08026036620140076,
0.09477176517248154,
-0.016387617215514183,
0.016990656033158302,
-0.08228129148483276,
-0.013419480063021183,
0.09099746495485306,
-0.12665517628192902,
-0.11556627601385117,
-0.06357208639383316,
0.13796506822109222,
-0.03748014569282532,
-0.06792362779378891,
-0.11707259714603424,
-0.03880562260746956,
0.021529851481318474,
0.1335168182849884,
-0.20159269869327545,
-0.020768262445926666,
0.03235907480120659,
0.17776764929294586,
-0.13711069524288177,
0.054383035749197006,
0.1364498734474182,
-0.0664997398853302,
-0.13668900728225708,
-0.05714643374085426,
0.06318619847297668,
-0.04915833845734596,
-0.037615757435560226,
-0.030773334205150604,
0.16446112096309662,
-0.04886315017938614,
-0.18910305202007294,
0.07617077976465225,
-0.016795340925455093,
0.09917127341032028,
-0.018028702586889267,
0.17936013638973236,
0.1950056403875351,
-0.07366102188825607,
0.06003068387508392,
-0.06908491253852844,
0.010838094167411327,
-0.01070399209856987,
-0.02660319395363331,
0.013416670262813568,
-0.06685419380664825,
-0.02624829299747944,
-0.03683823347091675,
-0.09697310626506805,
-0.18608561158180237,
0.0381377749145031,
0.14146940410137177,
-0.1311713010072708,
0.07777606695890427,
-0.01577705889940262,
-0.17565688490867615,
0.03242841362953186,
0.033038247376680374,
-0.10881786793470383,
-0.11456996947526932,
-0.020494369789958,
0.029386846348643303,
0.09281162917613983,
0.1401824951171875,
0.15178707242012024,
0.040599074214696884,
0.09011775255203247,
-0.24185405671596527,
-0.048800211399793625,
0.0538560152053833,
0.024362187832593918,
0.08835064619779587,
-0.12078657001256943,
-0.029829923063516617,
-0.050800859928131104,
-0.027568737044930458,
0.11569537967443466,
-0.08833982795476913,
-0.07752125710248947,
0.04416066035628319,
0.10488185286521912,
-0.03403449431061745,
-0.036388035863637924,
-0.028469476848840714,
0.00013972366286907345,
-0.02620040997862816,
0.019505295902490616,
0.03172631934285164,
-0.009704504162073135,
-0.008721652440726757,
0.02358195185661316,
-0.02107628993690014,
0.10953398793935776,
-0.12684720754623413,
-0.011352095752954483,
0.20320820808410645,
0.11569026112556458,
0.06384299695491791,
0.07973365485668182,
0.07756686955690384,
-0.014700566418468952,
-0.07601739466190338,
-0.15688274800777435,
0.043123140931129456,
-0.07327551394701004,
0.11937576532363892,
-0.16742980480194092,
-0.06767740845680237,
-0.032997481524944305,
0.03229013830423355,
-0.07201521098613739,
0.020497772842645645,
0.1007266715168953,
0.10656307637691498,
-0.006670929957181215,
0.045204728841781616,
-0.11228744685649872,
0.03726661205291748,
-0.09642747044563293,
-0.021383125334978104,
0.09304244816303253,
0.16754911839962006,
0.046043168753385544,
-0.06674063950777054,
0.05671413242816925,
-0.1691814512014389,
-0.09079419821500778,
0.02362711913883686,
-0.03823481500148773,
0.032727308571338654,
0.027651354670524597,
-0.06272287666797638,
0.25346511602401733,
-0.0711563304066658,
-0.09735190868377686,
0.09871630370616913,
-0.09277880936861038,
0.17078223824501038,
-0.04301628842949867,
-0.12943820655345917,
0.09328215569257736,
-0.03212863951921463,
0.07257618755102158,
-0.0919959545135498,
-0.09690722078084946,
-0.014983730390667915,
-0.02383156679570675,
0.1599690020084381,
0.2708745300769806,
0.004232767503708601,
0.06919010728597641,
-0.18598918616771698,
-0.18889376521110535,
0.12317569553852081,
0.20423759520053864,
-0.018112223595380783,
0.05860372632741928,
0.04035134240984917,
0.23361057043075562,
-0.036147184669971466,
0.09624502807855606,
0.15925373136997223,
-0.05318930000066757,
0.0999671220779419,
-0.1810319870710373,
-0.05631474032998085,
0.24686497449874878,
-0.29344862699508667,
-0.08175241202116013,
-0.1502540409564972,
0.03189156949520111,
-0.21783162653446198,
-0.0316685251891613,
0.0770697370171547,
0.011430091224610806,
-0.20418010652065277,
0.12323997914791107,
-0.05420595780014992,
-0.06644335389137268,
0.017708318307995796,
-0.031245650723576546,
-0.069255530834198,
0.029646968469023705,
-0.010673110373318195,
-0.043574053794145584,
0.04528564214706421,
-0.010181069374084473,
0.17210781574249268,
-0.11144612729549408,
-0.03275112062692642,
-0.01416890136897564,
-0.11918938905000687,
0.16780740022659302,
-0.04347151517868042,
-0.07990653067827225,
-0.1383093297481537,
-0.07701651751995087,
0.13612787425518036,
0.06718118488788605,
-0.03026001900434494,
-0.10584010183811188,
0.1504666954278946,
0.04537953436374664,
-0.04277321323752403,
-0.07999415695667267,
-0.05302651226520538,
0.06232829764485359,
-0.06967832148075104,
0.006939463783055544,
0.03764990344643593,
-0.16889509558677673,
-0.0128104779869318,
-0.12893931567668915,
0.004090023227035999,
-0.10927903652191162,
0.02363210916519165,
-0.0021094942931085825,
0.09061166644096375,
-0.15584534406661987,
0.10387682914733887,
-0.05615909397602081,
-0.08126594126224518,
-0.12864066660404205,
-0.10040390491485596,
0.049997348338365555,
-0.06948837637901306,
-0.2262738049030304,
0.07372745871543884,
-0.0751219317317009,
-0.023589715361595154,
0.0006566792726516724,
0.015917714685201645,
0.015185697935521603,
0.1439286172389984,
-0.048737782984972,
0.04775804653763771,
-0.03251831233501434,
-0.08096536993980408,
0.11022157967090607,
0.08137879520654678,
0.06090184673666954,
-0.00013641569239553064,
-0.08019585907459259,
0.029292188584804535,
0.0633009821176529,
-0.12884356081485748,
0.08761142194271088,
0.026820791885256767,
-0.08458266407251358,
0.07295160740613937,
0.15415427088737488,
-0.0795522928237915,
0.11442394554615021,
0.02001115493476391,
0.09106463938951492,
-0.016615290194749832,
-0.21292705833911896,
0.10298934578895569,
0.05502275377511978,
0.0073677487671375275,
-0.2833021283149719,
0.02874218113720417,
-0.11885728687047958,
0.14102113246917725,
0.07653405517339706,
0.09427811205387115,
-0.18969523906707764,
0.029876410961151123,
0.09227520227432251,
-0.013809707947075367,
-0.19043710827827454,
0.2721906006336212,
-0.09463087469339371,
0.16874489188194275,
-0.0929885283112526,
-0.20977464318275452,
0.11410222947597504,
-0.24532605707645416,
0.1033991351723671,
-0.10767566412687302,
0.1346479207277298,
0.04692460969090462,
-0.06546223908662796,
-0.06456930190324783,
-0.016968602314591408,
-0.17973142862319946,
0.006486006546765566,
0.12100864946842194,
0.16770276427268982,
0.09269894659519196,
-0.02782367542386055,
0.08303628861904144,
-0.01005392987281084,
0.12554210424423218,
-0.0039508226327598095,
0.06577645242214203,
-0.16509583592414856,
0.04058369994163513,
-0.1464710533618927,
0.06944134086370468,
0.004074519500136375,
0.030400428920984268,
-0.23784418404102325,
-0.16445674002170563,
0.17691773176193237,
-0.04592552036046982,
-0.12712617218494415,
-0.0823761522769928,
0.09494348615407944,
0.1738746613264084,
0.09308170527219772,
-0.06952536106109619,
-0.018745578825473785,
0.057547252625226974,
0.07872483134269714,
0.09157146513462067,
0.04403744265437126,
0.016956856474280357,
-0.09269630163908005,
-0.029361916705965996,
-0.06743098795413971,
-0.28720706701278687,
0.07613074034452438,
0.005947081837803125,
-0.04800977557897568,
0.05805841088294983,
-0.22678130865097046,
0.00736323744058609,
-0.036018453538417816,
-0.09721697121858597,
0.21445755660533905,
0.14375033974647522,
-0.037552669644355774,
0.07481253147125244,
0.047465730458498,
0.12795665860176086,
0.0499894879758358,
0.3371717631816864,
0.1206621453166008,
0.04664211347699165,
0.07534867525100708,
0.11638755351305008,
-0.1137082502245903,
-0.01809467002749443,
0.027630813419818878,
-0.07026474177837372,
0.10068340599536896,
-0.033441174775362015,
-0.02745586819946766,
-0.09059090167284012,
-0.016674429178237915,
-0.09251946210861206,
-0.1066908910870552,
-0.14217059314250946,
-0.0029501612298190594,
-0.10616209357976913,
-0.12213589251041412,
0.23970355093479156,
-0.06059916317462921,
0.09325772523880005,
-0.027130169793963432,
0.08298519998788834,
-0.11706145107746124,
-0.025369465351104736,
0.02586756832897663,
-0.10644304752349854,
0.07422038167715073,
0.011267676949501038,
0.040812499821186066,
0.11823710054159164,
-0.12311052531003952,
0.036918528378009796,
-0.09282504767179489,
-0.07867162674665451,
0.09925122559070587,
0.00831183698028326,
0.07572954893112183,
0.18012267351150513,
-0.11015387624502182,
0.25394564867019653,
0.0647750273346901,
-0.010540131479501724,
-0.14140892028808594,
0.09216330945491791,
0.14021435379981995,
-0.07399103045463562,
0.030010830610990524,
-0.0632258877158165,
0.026569640263915062,
-0.31273141503334045,
0.09507186710834503,
0.048706747591495514,
0.03564697876572609,
0.0877167135477066,
0.044927213340997696,
0.0967792421579361,
-0.12211425602436066,
-0.1670200675725937,
0.09019871801137924,
0.036771178245544434,
-0.01080002449452877,
0.07695483416318893,
0.17063258588314056,
0.04803616926074028,
-0.10535462200641632,
0.06133848801255226,
0.10331029444932938,
-0.0652971938252449,
0.12990865111351013,
0.06802456825971603,
0.031069843098521233,
-0.06295310705900192,
-0.0010956355836242437,
-0.042811691761016846,
0.05890437588095665,
-0.03734767809510231,
-0.0005172397359274328,
0.023220261558890343,
-0.13965068757534027,
-0.07897917926311493,
-0.0788731500506401,
0.023132644593715668,
0.04229813814163208,
0.0890314057469368,
-0.07917604595422745,
-0.03219835087656975,
0.1405557245016098,
-0.03651417791843414,
-0.04889789968729019,
0.03253275156021118,
-0.08247864246368408,
-0.03458242863416672,
-0.04264979436993599,
-0.04301273822784424,
-0.09590031951665878,
0.13572357594966888,
0.0012255808105692267,
0.16827429831027985,
0.0843420997262001,
-0.09352738410234451,
0.03125839680433273,
-0.28809845447540283,
0.08971253037452698,
-0.049394357949495316,
0.11219234764575958,
-0.16251173615455627
] | [
-0.6405137181282043,
-0.40237531065940857,
-0.4379032552242279,
0.4858168959617615,
0.026843443512916565,
0.8250871896743774,
0.591051459312439,
0.49869590997695923,
-0.05352409556508064,
-0.5380819439888,
-0.030063176527619362,
0.1934276521205902,
-0.17665459215641022,
-0.2884982228279114,
0.21587994694709778,
0.6314683556556702,
0.07805005460977554,
0.01826055534183979,
0.7228599190711975,
-0.17166107892990112,
0.09680569171905518,
-0.02651747688651085,
0.3800112009048462,
0.005414656829088926,
-0.27775484323501587,
-0.3200223743915558,
-0.5080534815788269,
-0.2075829803943634,
-0.3583580255508423,
0.2830114960670471,
-0.5827750563621521,
0.12257585674524307,
0.436928391456604,
0.3532000184059143,
0.564717710018158,
0.048827674239873886,
-0.07594364136457443,
-0.12622830271720886,
0.053892455995082855,
0.07402795553207397,
-0.5602610111236572,
0.11546620726585388,
0.21992602944374084,
0.2670930027961731,
0.18983040750026703,
-0.04674329236149788,
-1.2200636863708496,
0.3175443112850189,
-0.17276346683502197,
-0.8183501362800598,
-0.5250676274299622,
-0.19748036563396454,
0.3238544166088104,
0.5963900089263916,
0.11509183794260025,
-0.107943594455719,
0.35183751583099365,
0.2924298644065857,
-0.15422554314136505,
0.19241882860660553,
0.8530176877975464,
0.5063220262527466,
0.34927883744239807,
0.2658578157424927,
-0.23652294278144836,
0.05941621586680412,
0.42366692423820496,
0.050829172134399414,
-0.19484123587608337,
-0.711532711982727,
0.17822271585464478,
0.7535077333450317,
0.14014923572540283,
0.10093405097723007,
-0.3228948712348938,
0.20055116713047028,
-0.19007807970046997,
0.28901323676109314,
0.10063039511442184,
-0.03848069906234741,
-0.1955675482749939,
-0.8078544735908508,
0.04586132615804672,
-0.11808034032583237,
-0.24477964639663696,
-0.40330132842063904,
0.8196008801460266,
-0.13639597594738007,
-0.9123497605323792,
0.4288228750228882,
-0.7800590991973877,
0.031614482402801514,
0.29552367329597473,
0.5088914632797241,
0.5439472794532776,
-0.18054720759391785,
-0.21971161663532257,
-0.05083504319190979,
0.6170822978019714,
-0.712860107421875,
-0.5503864288330078,
-0.9498862028121948,
-0.5838750004768372,
-0.03559653460979462,
-0.6456656455993652,
0.021811138838529587,
-1.0994744300842285,
0.11977823823690414,
-0.3225787580013275,
0.3308296799659729,
-0.7427442669868469,
-0.19227683544158936,
0.3549487292766571,
0.19111023843288422,
-0.39548635482788086,
-0.023019053041934967,
-0.0343155562877655,
-0.17994794249534607,
-0.1811835765838623,
-0.1845594048500061,
-0.005594165064394474,
0.1260816603899002,
-0.17074158787727356,
0.2197311520576477,
-0.20783691108226776,
0.035901594907045364,
-0.366798460483551,
0.30805057287216187,
-0.12659867107868195,
0.17417366802692413,
-0.03723131865262985,
-0.23911958932876587,
-0.2008027583360672,
0.026582183316349983,
-0.21551357209682465,
-0.5486097931861877,
-0.21325384080410004,
0.052347972989082336,
-0.03783343732357025,
0.07125475257635117,
-0.13377344608306885,
0.008458757773041725,
0.27349352836608887,
-0.34788942337036133,
0.39084601402282715,
-0.6821686029434204,
-0.6143672466278076,
0.24633195996284485,
-0.7538977265357971,
0.05913751944899559,
0.25489965081214905,
0.35555312037467957,
-0.1638355553150177,
0.3167976140975952,
0.3675808012485504,
0.3050578832626343,
0.007362578995525837,
-0.15388232469558716,
-0.3047502338886261,
-0.0821155235171318,
0.35859501361846924,
0.6810493469238281,
0.2259669452905655,
-0.08428235352039337,
0.7316536903381348,
-0.22368060052394867,
-0.6080368161201477,
0.48941099643707275,
-0.19647999107837677,
0.2771236002445221,
-0.5139791965484619,
-0.662840723991394,
0.27492234110832214,
-0.1847514808177948,
-0.250088095664978,
0.48996007442474365,
0.2121702879667282,
0.3231496810913086,
0.4580309987068176,
-0.3447554409503937,
-0.23925529420375824,
0.034911416471004486,
-0.20812639594078064,
0.06909839808940887,
0.10304594039916992,
-0.3709271252155304,
0.7266157865524292,
-0.01675555296242237,
0.24747776985168457,
-0.05028047785162926,
-0.44722867012023926,
0.11035291850566864,
0.42860254645347595,
0.007925187237560749,
0.03177899494767189,
-0.14207139611244202,
0.025058120489120483,
-0.006179651711136103,
-0.5869449973106384,
-0.5620450377464294,
-0.08105451613664627,
-0.01896088942885399,
0.08508529514074326,
-0.06164143607020378,
-0.6453149318695068,
0.2898566424846649,
-0.19194786250591278,
-0.8347829580307007,
-0.17305921018123627,
0.16413678228855133,
-0.01736634038388729,
0.29173094034194946,
-0.31920695304870605,
0.2484014332294464,
0.03193426504731178,
-0.05750153586268425,
-0.5523152947425842,
-0.37817129492759705,
-0.031182529404759407,
0.010498217307031155,
0.6141337156295776,
0.005562508013099432,
0.5754885673522949,
0.09742695093154907,
0.24905730783939362,
0.595888614654541,
0.3569446802139282,
-0.04178495332598686,
0.2616642415523529,
-0.33417198061943054,
-0.44338324666023254,
-0.18796509504318237,
-0.07724089920520782,
0.09030621498823166,
-0.18053226172924042,
-0.038269173353910446,
0.2791324555873871,
-0.3814674913883209,
0.440965473651886,
-0.4539218246936798,
-0.437311589717865,
0.27674201130867004,
-0.39244967699050903,
0.32035577297210693,
-0.34466156363487244,
0.2573222815990448,
0.030993448570370674,
0.2983739972114563,
-0.009839211590588093,
-0.38673514127731323,
0.11693607270717621,
-0.066309355199337,
-0.4121782183647156,
-0.1592489331960678,
0.7279937863349915,
-0.3668922781944275,
-0.6626343131065369,
-0.6304081082344055,
0.43349120020866394,
0.1777256727218628,
-0.11462395638227463,
0.4747953712940216,
0.04924236983060837,
-0.6568655371665955,
0.10712870955467224,
-0.2694474160671234,
-1.0508304834365845,
-1.1156034469604492,
0.39187684655189514,
-0.21080021560192108,
0.3013175129890442,
-0.02215932123363018,
-0.2811366319656372,
-0.37139707803726196,
-0.48152124881744385,
0.3146005868911743,
-0.023905877023935318,
0.2040567845106125,
-0.2825774848461151,
-0.6946139335632324,
0.10420634597539902,
0.7348901629447937,
-0.4308755397796631,
-0.3500937521457672,
-0.7078908085823059,
0.032581526786088943,
-0.06528077274560928,
-0.14389154314994812,
0.4443519115447998,
-0.3639358878135681,
-0.5161067247390747,
0.380062073469162,
0.3595781922340393,
0.2841747999191284,
-0.1788645088672638,
-0.1404784470796585,
-0.35559791326522827,
0.7628968358039856,
0.7743830680847168,
-0.26581716537475586,
0.2301884889602661,
0.248964324593544,
0.04240370914340019,
0.33601459860801697,
0.686220645904541,
-0.11663446575403214,
0.05191066861152649,
0.05023445561528206,
-5.926717758178711,
0.15985824167728424,
0.41227540373802185,
0.03696600720286369,
-0.06717564165592194,
-0.685660183429718,
-0.4523402154445648,
-0.00650072330608964,
0.6943573951721191,
-0.029640253633260727,
-0.2096613347530365,
-0.25302255153656006,
-0.2442178875207901,
0.3812408447265625,
0.215958833694458,
0.19777575135231018,
0.4026188850402832,
-0.5023983120918274,
0.30367109179496765,
0.43691158294677734,
0.02853456512093544,
0.1861387938261032,
-0.08519032597541809,
0.40896081924438477,
-0.1732265204191208,
0.446936696767807,
-0.3138706386089325,
0.4826297461986542,
-0.7074016332626343,
-0.14766176044940948,
-0.5846761465072632,
-0.09030564874410629,
-0.591183602809906,
-0.501499593257904,
-0.005868382286280394,
0.3856718838214874,
-0.028344735503196716,
-0.19734036922454834,
0.5262187719345093,
0.26671701669692993,
-0.3591674566268921,
0.4326573610305786,
-0.2670843005180359,
0.5088358521461487,
0.3468944728374481,
0.278751939535141,
0.9903849363327026,
0.050294771790504456,
-0.24699676036834717,
0.21231505274772644,
0.2671973407268524,
0.200454980134964,
0.8399147987365723,
-0.1555546373128891,
0.14770430326461792,
0.22617369890213013,
-0.34804847836494446,
-0.7687944769859314,
0.28784874081611633,
-0.1287899911403656,
-0.20163242518901825,
-0.1705934703350067,
0.31160253286361694,
0.3891797363758087,
-0.6762845516204834,
-0.03927423804998398,
-0.24367013573646545,
0.7660377025604248,
0.6083751916885376,
-0.11142442375421524,
0.4186219871044159,
0.13385175168514252,
-0.10049636662006378,
-0.7557066679000854,
-0.07680846005678177,
-0.09487045556306839,
-0.030416471883654594,
-0.056824762374162674,
-0.49155884981155396,
-0.19291633367538452,
-0.1154153123497963,
-0.0441974475979805,
0.0636155754327774,
0.12494843453168869,
0.5879583358764648,
-0.5662126541137695,
0.04872671514749527,
0.01690656691789627,
-0.14738738536834717,
0.15299998223781586,
-0.4060676395893097,
-1.2508771419525146,
0.4381316006183624,
-0.48191437125205994,
0.8022720813751221,
0.5865172743797302,
-0.029726622626185417,
0.0035025940742343664,
0.30741146206855774,
-0.19067350029945374,
0.10247617214918137,
0.15762104094028473,
-0.29479309916496277,
0.2469588965177536,
-0.14295031130313873,
0.6153372526168823,
-0.2612922787666321,
0.410405695438385,
0.3434380888938904,
-0.9637153744697571,
0.37005409598350525,
0.8671360015869141,
-0.07724590599536896,
0.5419739484786987,
-0.22870415449142456,
-0.195687398314476,
-0.13765989243984222,
-0.11901091784238815,
-0.3170420229434967,
-0.813113808631897,
-0.09001196175813675,
0.2522040605545044,
-0.1321377009153366,
-0.44381189346313477,
-0.1272321492433548,
0.337159663438797,
-0.034877993166446686,
-0.18754339218139648,
0.10602138191461563,
0.9518159627914429,
0.4172194004058838,
0.08056331425905228,
0.23670290410518646,
-0.26023632287979126,
0.598850429058075,
0.0900973454117775,
0.13066397607326508,
-0.677077054977417,
-0.3661991357803345,
0.04574254900217056,
0.3012562394142151,
0.02984621934592724,
-0.04079459235072136,
-0.1463468372821808,
0.3255300521850586,
-0.3803701400756836,
0.16178934276103973,
-0.2730391025543213,
-0.1169378012418747,
-0.32213449478149414,
-0.026793222874403,
-0.11395637691020966,
0.5738397836685181,
-0.14538982510566711,
-0.12061220407485962,
-0.4149736762046814,
-0.04234865680336952,
-0.3475729525089264,
-0.343759149312973,
-0.43574774265289307,
0.4395364224910736,
-0.5820834040641785,
-0.03472289443016052,
0.03676805645227432,
0.13348166644573212,
-0.3336793780326843,
-0.10264715552330017,
0.0874810665845871,
0.27708879113197327,
-0.2545282542705536,
-0.018138179555535316,
-0.6050015687942505,
0.09920167922973633,
0.16164147853851318,
0.14675846695899963,
0.012121990323066711,
-0.3198172152042389,
0.01902514323592186,
-0.26108139753341675,
0.07013783603906631,
-0.22209352254867554,
-0.2217928171157837,
-0.3744063675403595,
0.4201135039329529,
-0.04484299197793007,
0.3405519723892212,
-0.7450613975524902,
0.024716639891266823,
0.45330923795700073,
0.6937953233718872,
0.0752611756324768,
-0.832017183303833,
-0.045036546885967255,
0.5537779331207275,
-0.18164633214473724,
-0.35486695170402527,
0.25607869029045105,
-0.2295973151922226,
-0.02589963562786579,
-0.12025386095046997,
0.1403854638338089,
-0.2387540489435196,
-0.2451774626970291,
0.13782870769500732,
-0.5679054260253906,
-0.41225868463516235,
0.4581570625305176,
-0.20775218307971954,
-0.23662292957305908,
0.04961321875452995,
-0.18901465833187103,
-0.6870233416557312,
-0.5773178935050964,
0.18307825922966003,
-0.2945728302001953,
-0.38617920875549316,
-0.22496278584003448,
0.015849879011511803,
-0.268669992685318,
-0.2749374806880951,
0.03696984052658081,
-0.8148856163024902,
-0.38810479640960693,
-0.025172395631670952,
-0.1502196341753006,
0.04896705970168114,
0.22394172847270966,
-0.05397177115082741,
0.2469419240951538,
-0.03264225274324417,
-0.42337819933891296,
1.041951298713684,
-0.23077920079231262,
0.5565585494041443,
-0.31003889441490173,
0.608592689037323,
-0.7702485918998718,
0.08621510863304138,
-0.6096031665802002,
-0.02853826992213726,
0.29969823360443115,
0.2085707187652588,
-0.4000083804130554,
0.6077346205711365,
-0.518153965473175,
0.34654539823532104,
0.28409817814826965,
-0.6033403873443604,
-0.05450035631656647,
0.4529287815093994,
-0.6848151683807373,
0.0723842903971672,
0.20467908680438995,
-0.10367891937494278,
0.44089752435684204,
-0.36706554889678955,
0.18545079231262207,
-0.10165735334157944,
0.12503987550735474,
-0.046692509204149246,
-0.07009854167699814,
0.18909285962581635,
0.35962802171707153,
0.08282849192619324,
0.04460080713033676,
0.0568276047706604,
0.6421523094177246,
0.2641369700431824,
0.06410586833953857,
0.27596914768218994,
0.29972729086875916,
-0.7036498188972473,
-0.16414666175842285,
0.033663712441921234,
0.07351209223270416,
0.20434892177581787,
-0.46359142661094666,
-0.5439566373825073,
-0.9238333106040955,
0.7518335580825806,
-0.23520536720752716,
0.1129995658993721,
-0.23092907667160034,
0.11087613552808762,
-0.09935221821069717,
-0.9354085326194763,
0.16645683348178864,
0.17975454032421112,
-0.5378636717796326,
-0.5492104291915894,
0.41337937116622925,
0.5800880789756775,
0.10638631135225296,
-0.33817175030708313,
0.5746670961380005,
-0.022355975583195686,
-0.2026936411857605,
0.31927573680877686,
0.40780094265937805,
-0.05101113021373749,
-0.13658465445041656,
-0.8546320796012878,
-0.2016657441854477,
0.03351324796676636,
-0.1771748811006546,
-0.37395960092544556,
-0.03345078229904175,
-0.6526021361351013,
0.12836319208145142,
0.1983776092529297,
0.6344493627548218,
-0.4830472469329834,
0.00027233120636083186,
0.5377674102783203,
0.24042531847953796,
-0.018643002957105637,
0.20486709475517273,
-0.12828630208969116,
0.4258779287338257,
0.036379870027303696,
-0.12309711426496506,
0.968438446521759,
0.34873682260513306,
-0.10962457954883575,
-0.2355499267578125,
0.5139114856719971,
0.04202704504132271,
0.39189770817756653,
-0.1655423492193222,
0.05406373739242554,
0.7246348261833191,
0.09051239490509033,
0.22606003284454346,
0.4750409722328186,
-0.2502919137477875,
-0.41616392135620117,
0.3024485409259796,
-0.09973996132612228,
0.31970423460006714,
0.7033059597015381,
-0.14586137235164642,
-0.6549742221832275,
0.41837021708488464,
0.5309693217277527,
-0.09886568039655685,
0.3642052412033081,
0.17431573569774628,
0.18348105251789093,
-0.7551875710487366,
0.7793015241622925,
0.3865963816642761,
0.42172300815582275,
0.010295970365405083,
0.6963356733322144,
-0.21687792241573334,
-0.13037286698818207,
0.6820765137672424,
-0.027327176183462143,
-0.17987865209579468,
-0.07623502612113953,
0.5820028185844421,
0.35144758224487305,
0.09853458404541016,
-0.41020703315734863,
-1.1194757223129272,
0.6177181005477905,
0.2997124493122101,
-0.031544096767902374,
-0.06057187542319298,
-0.3863482177257538,
-0.5932437181472778,
-0.016541818156838417,
-0.17606118321418762,
0.8261231780052185,
0.457338809967041,
0.6508395075798035,
-0.0012006243923678994,
0.5394740104675293,
0.15253518521785736,
0.1912892609834671,
-0.43653446435928345,
0.17960892617702484,
-0.6596009135246277,
-0.2381877303123474,
0.01935752108693123,
-0.3261159658432007,
-0.1887521892786026,
0.29278498888015747,
0.3507181704044342,
0.19733290374279022,
-0.1805429607629776,
0.6191128492355347,
0.22348980605602264,
0.17281083762645721,
-0.2651877999305725,
-0.0181918703019619,
0.0824960470199585,
0.4466002881526947,
-0.030238976702094078,
0.28071486949920654,
0.23278141021728516,
0.2960681915283203,
0.18854571878910065,
0.32386285066604614,
-0.22935795783996582,
0.16373533010482788,
-0.31030547618865967,
0.3944079577922821,
-0.10205652564764023,
-0.27200567722320557,
0.2351718693971634,
0.1578563153743744,
-0.4197356700897217,
0.30079665780067444,
0.5369536876678467,
-0.018321508541703224,
-0.19461378455162048,
-0.057749275118112564,
0.5191723704338074,
-0.5366772413253784,
-0.2823029160499573,
-0.30010727047920227,
0.48116350173950195,
0.5730797052383423,
0.4100930392742157,
0.7864708304405212,
-0.25818997621536255,
0.06303063780069351,
-0.14138896763324738,
0.10440759360790253,
-0.022119775414466858,
-0.05415227636694908,
-0.4690716862678528,
-0.0709342360496521,
-0.22036102414131165,
-0.42220842838287354,
0.48474106192588806,
-0.46471768617630005,
0.4343828856945038,
-0.17350706458091736,
-0.04658008739352226,
0.04700089618563652,
0.530000627040863,
-0.028570136055350304,
0.434516042470932,
-0.6207054853439331,
0.6326807737350464,
0.35986989736557007,
-0.19263778626918793,
0.8151133060455322,
-0.0821625366806984,
-0.09531925618648529,
0.04366768151521683,
-0.11371362954378128,
0.5795555710792542,
-0.13917334377765656,
-0.04046087712049484,
-0.2095411717891693,
0.17678895592689514,
0.14281535148620605
] |
|
BACKGROUND: Expression of the minor virion structural protein VP2 of the calicivirus murine norovirus (MNV) is believed to occur by the unusual mechanism of termination codon-dependent reinitiation of translation. In this process, following translation of an upstream open reading frame (ORF) and termination at the stop codon, a proportion of 40S subunits remain associated with the mRNA and reinitiate at the AUG of a downstream ORF, which is typically in close proximity. Consistent with this, the VP2 start codon (AUG) of MNV overlaps the stop codon of the upstream VP1 ORF (UAA) in the pentanucleotide UAA UG. PRINCIPAL FINDINGS: Here, we confirm that MNV VP2 expression is regulated by termination-reinitiation and define the mRNA sequence requirements. Efficient reintiation is dependent upon 43 nt of RNA immediately upstream of the UAA UG site. Chemical and enzymatic probing revealed that the RNA in this region is not highly structured and includes an essential stretch of bases complementary to 18S rRNA helix 26 (Motif 1). The relative position of Motif 1 with respect to the UAA UG site impacts upon the efficiency of the process. Termination-reinitiation in MNV was also found to be relatively insensitive to the initiation inhibitor edeine. CONCLUSIONS: The termination-reinitiation signal of MNV most closely resembles that of influenza BM2. Similar to other viruses that use this strategy, base-pairing between mRNA and rRNA is likely to play a role in tethering the 40S subunit to the mRNA following termination at the VP1 stop codon. Our data also indicate that accurate recognition of the VP2 ORF AUG is not a pre-requisite for efficient reinitiation of translation in this system. | [
-0.005330775864422321,
0.022486329078674316,
-0.007405445910990238,
0.013389445841312408,
-0.009688572958111763,
-0.005931610241532326,
0.010370513424277306,
0.016446884721517563,
-0.009215832687914371,
0.0034300521947443485,
-0.01635092683136463,
0.00883655808866024,
-0.01137270126491785,
0.02775390073657036,
0.020110666751861572,
0.000004122965037822723,
-0.014578033238649368,
-0.011129595339298248,
0.01139697153121233,
-0.012239059433341026,
0.010568260215222836,
-0.024566981941461563,
0.009879304096102715,
-0.015001441352069378,
0.034761883318424225,
0.0004081916995346546,
-0.011475136503577232,
0.021097781136631966,
0.007447744719684124,
-0.003054673783481121,
0.009336484596133232,
-0.008294517174363136,
0.003418882843106985,
0.023665346205234528,
0.0032331394031643867,
-0.014903455972671509,
-0.001922299969010055,
0.024756167083978653,
0.015797460451722145,
-0.006145171821117401,
0.016311518847942352,
-0.015399319119751453,
0.010995512828230858,
-0.010391457006335258,
-0.00898272916674614,
-0.021775785833597183,
-0.0025541603099554777,
-0.0005662217736244202,
0.0002782321535050869,
0.0030079539865255356,
0.0023087942972779274,
-0.0016643754206597805,
-0.009784049354493618,
0.04092980921268463,
-0.00540583673864603,
-0.0029110461473464966,
0.01807999424636364,
-0.012387208640575409,
-0.013735608197748661,
-0.014902946539223194,
0.012333246879279613,
0.003980578854680061,
-0.017448272556066513,
-0.015542839653789997,
0.007551299408078194,
-0.06705734133720398,
-0.01189904473721981,
0.00429785531014204,
-0.0028580352663993835,
0.03085809014737606,
0.008865582756698132,
0.004108055494725704,
-0.015479492023587227,
-0.02099052257835865,
-0.004931616131216288,
-0.001347048208117485,
-0.017066901549696922,
-0.010663500055670738,
-0.006661440245807171,
-0.010393929667770863,
0.020813295617699623,
-0.007860878482460976,
-0.019758889451622963,
-0.005569356493651867,
0.01417043711990118,
0.0176591444760561,
-0.029941381886601448,
0.022168515250086784,
0.001164040993899107,
-0.000719113857485354,
0.03769294172525406,
-0.020359931513667107,
0.004999447148293257,
0.026333965361118317,
0.0001925034448504448,
0.008286280557513237,
-0.00929039902985096,
-0.021235952153801918,
0.01597697287797928,
-0.027854561805725098,
-0.0243975967168808,
0.0037420750595629215,
0.017295746132731438,
-0.016820892691612244,
-0.011445973999798298,
0.004155791364610195,
0.014109598472714424,
0.02486162818968296,
0.029553674161434174,
0.00715826777741313,
-0.015848485752940178,
-0.005514105781912804,
0.013420436531305313,
0.018786251544952393,
0.005675091408193111,
0.0024454882368445396,
0.018678192049264908,
0.01707455888390541,
-0.0011377568589523435,
0.023460594937205315,
0.004247307777404785,
0.012307784520089626,
0.0008254428394138813,
-0.008993820287287235,
0.010354718193411827,
-0.0034344925079494715,
-0.0034055837895721197,
-0.02522994577884674,
0.01201474666595459,
0.00631241500377655,
-0.009690997190773487,
0.01764643006026745,
-0.010961510241031647,
-0.018193397670984268,
0.007655532564967871,
0.009810414165258408,
-0.002054452197626233,
-0.03207474201917648,
0.008796242997050285,
-0.005755406338721514,
0.02642696164548397,
0.008054396137595177,
-0.0009196359314955771,
0.00927431508898735,
-0.01635197550058365,
0.005413219798356295,
-0.010036572813987732,
0.02249988168478012,
0.004394314251840115,
-0.008188337087631226,
0.0001412215642631054,
-0.01476763840764761,
-0.005797640886157751,
-0.019102972000837326,
-0.00004355877172201872,
-0.01718374341726303,
-0.015491250902414322,
-0.012931915000081062,
-0.011593935079872608,
0.01606938987970352,
0.010385937057435513,
-0.0350225567817688,
0.021917516365647316,
0.008823735639452934,
0.016606319695711136,
0.017276253551244736,
-0.0019415621645748615,
-0.006138855591416359,
0.007959255948662758,
0.008917726576328278,
0.014120019041001797,
-0.013055224902927876,
0.021973975002765656,
0.006701027043163776,
0.020553385838866234,
-0.007780279498547316,
0.019946206361055374,
0.005938983988016844,
-0.008097518235445023,
0.06657884269952774,
0.020433945581316948,
0.020491449162364006,
0.010671279393136501,
0.006976481527090073,
0.007405742537230253,
-0.032505422830581665,
0.004683478269726038,
-0.0018752510659396648,
-0.004766714293509722,
-0.005525506101548672,
0.004748179577291012,
-0.018176496028900146,
-0.02357465773820877,
-0.001970214769244194,
-0.00878401193767786,
0.002742117503657937,
0.0010084440000355244,
0.01248449832201004,
0.023926131427288055,
0.02640092559158802,
-0.013136407360434532,
-0.015965059399604797,
0.01838875375688076,
-0.01510629616677761,
-0.038574717938899994,
0.007667625322937965,
0.012751568108797073,
0.02203025296330452,
-0.004960670601576567,
0.01312321238219738,
0.019775129854679108,
0.008752278983592987,
-0.01198621466755867,
-0.013628317043185234,
0.022079026326537132,
-0.00627509318292141,
0.008491399697959423,
0.025089889764785767,
-0.01849982887506485,
-0.008555321022868156,
-0.005450573284178972,
0.013625746592879295,
-0.009245920926332474,
-0.001981402514502406,
0.0054467711597681046,
0.023115020245313644,
0.005842182785272598,
0.009352270513772964,
0.003415693063288927,
0.005413757171481848,
-0.019765306264162064,
-0.005942147225141525,
-0.01452716439962387,
0.013291609473526478,
0.007674007676541805,
-0.004022989422082901,
0.012982763350009918,
-0.012805813923478127,
0.017728187143802643,
-0.011310716159641743,
-0.009381739422678947,
-0.007646196521818638,
0.008178533986210823,
-0.032378703355789185,
0.018810534849762917,
-0.03527755290269852,
-0.005711171310395002,
0.015272843651473522,
0.037795983254909515,
-0.028745952993631363,
0.010685165412724018,
0.005027594044804573,
0.03167197108268738,
-0.04649332910776138,
0.020014386624097824,
-0.0019563622772693634,
-0.007807479240000248,
0.0350940078496933,
0.022817548364400864,
0.016299104318022728,
-0.000897399615496397,
0.007379087619483471,
0.005607346072793007,
0.013253930024802685,
-0.0015262523666024208,
0.010770189575850964,
-0.01510477252304554,
-0.00829109363257885,
-0.0024177832528948784,
0.011723589152097702,
0.009457710199058056,
-0.011699611321091652,
-0.007325156591832638,
-0.08128243684768677,
-0.005140318535268307,
-0.00811185035854578,
0.009079543873667717,
0.0005054580396972597,
0.017372552305459976,
0.013521533459424973,
-0.02364221028983593,
-0.014608335681259632,
-0.011471453122794628,
-0.0031996257603168488,
0.010000806301832199,
-0.009595678187906742,
-0.01478493120521307,
0.013278958387672901,
-0.010150659829378128,
0.016190476715564728,
0.007154280785471201,
-0.016389522701501846,
-0.016332827508449554,
-0.0026356263551861048,
0.014004110358655453,
0.006042734254151583,
0.00894692912697792,
-0.01454644650220871,
0.00007229810580611229,
0.01749066822230816,
0.028215158730745316,
-0.005316979251801968,
-0.006662992760539055,
-0.002646086271852255,
-0.010037247091531754,
0.03912205249071121,
-0.005231809802353382,
0.013132572174072266,
0.02352585271000862,
-0.004287575371563435,
0.011970343068242073,
-0.005521124694496393,
0.021555261686444283,
-0.015939123928546906,
0.01623540371656418,
-0.0009776987135410309,
-0.0097610829398036,
-0.004248832352459431,
0.008549289777874947,
0.010089058429002762,
-0.013259288854897022,
0.023504674434661865,
0.0035360106267035007,
0.03404723107814789,
-0.014635521918535233,
0.022022966295480728,
0.019396595656871796,
-0.005395766347646713,
0.008016491308808327,
-0.020268037915229797,
-0.029040705412626266,
-0.00425314623862505,
-0.0036077529657632113,
-0.008556222543120384,
-0.003929308615624905,
0.00835506897419691,
0.018114259466528893,
-0.009614956565201283,
0.0027092830277979374,
0.006352049298584461,
-0.011973744258284569,
-0.024401525035500526,
0.016833513975143433,
-0.0078061423264443874,
0.0091217877343297,
-0.00798474159091711,
-0.00728025333955884,
-0.0035199811682105064,
-0.012283310294151306,
-0.010516325011849403,
-0.00649062916636467,
-0.015407691709697247,
-0.03890553116798401,
-0.0490633100271225,
0.008332597091794014,
0.01276206411421299,
-0.011910001747310162,
-0.024468496441841125,
-0.0074523682706058025,
0.01170601136982441,
0.03286375850439072,
0.008897736668586731,
-0.013952450826764107,
0.023445075377821922,
0.0116785429418087,
-0.01972605101764202,
0.018187448382377625,
0.000021286774426698685,
-0.04163546860218048,
0.013449741527438164,
0.006500476971268654,
0.003518537152558565,
0.007557457312941551,
-0.0013270394410938025,
-0.0014941263943910599,
0.01404193602502346,
-0.007321972865611315,
-0.010543642565608025,
0.0068024154752492905,
-0.00954446755349636,
-0.007253213319927454,
-0.00556021137163043,
0.0021493781823664904,
-0.00027852365747094154,
0.02046121470630169,
-0.004208847880363464,
0.003275400958955288,
0.009977353736758232,
0.01662716269493103,
0.004058460239320993,
-0.03857596218585968,
0.0723317563533783,
0.01970192976295948,
0.0014055647188797593,
-0.00023024133406579494,
0.012040961533784866,
-0.010992377996444702,
-0.020620783790946007,
0.025639113038778305,
-0.01828712597489357,
0.005572003312408924,
0.010737122967839241,
-0.04555468261241913,
0.006525748409330845,
-0.018650345504283905,
0.003916068468242884,
-0.0053300862200558186,
0.00967398751527071,
-0.0204593725502491,
0.026717672124505043,
0.01756180450320244,
0.020328352227807045,
0.006195012014359236,
-0.012684246525168419,
-0.019888771697878838,
-0.005167253781110048,
-0.01125876884907484,
0.01906270533800125,
-0.01383138820528984,
-0.020644795149564743,
0.01507297158241272,
-0.00933535024523735,
-0.04014652967453003,
-0.010848558507859707,
-0.029131529852747917,
0.014120286330580711,
-0.014268985018134117,
0.00730533292517066,
-0.004438135772943497,
-0.005618334282189608,
-0.0227177944034338,
-0.0035764279309660196,
-0.014978926628828049,
0.021441085264086723,
0.011801154352724552,
-0.00036608148366212845,
-0.02517886832356453,
0.005252467934042215,
-0.007045685313642025,
0.0039759306237101555,
0.000973893329501152,
-0.015842653810977936,
-0.017386164516210556,
0.007985759526491165,
0.02663511224091053,
-0.022500455379486084,
0.0006616285536438227,
0.0037604065146297216,
-0.01066666841506958,
-0.009128335863351822,
-0.004951621405780315,
0.014908850193023682,
-0.036778613924980164,
0.021250944584608078,
-0.015187191776931286,
-0.0019609197042882442,
-0.03329183906316757,
0.0023628780618309975,
0.0068919602781534195,
0.009748232550919056,
-0.0034760870039463043,
0.007439536973834038,
-0.03175561875104904,
-0.0061860037967562675,
0.002486949786543846,
-0.00628467183560133,
0.0009004019666463137,
0.020856164395809174,
-0.003032511565834284,
0.010239438153803349,
0.008677339181303978,
0.022044189274311066,
-0.022899972274899483,
0.012277830392122269,
-0.0031190519221127033,
0.0008041444234549999,
-0.0251791849732399,
-0.024708043783903122,
-0.07480667531490326,
-0.015631817281246185,
0.0022239689715206623,
-0.0060427626594901085,
0.0062459553591907024,
0.01606951653957367,
-0.01772088184952736,
-0.04195104539394379,
-0.0033729453571140766,
-0.00990290381014347,
0.011320946738123894,
0.009764404967427254,
0.013443751260638237,
0.0015769978053867817,
0.012404235079884529,
0.014736883342266083,
-0.009740689769387245,
0.004549543838948011,
-0.016368327662348747,
-0.009555133990943432,
-0.0007361220195889473,
0.0356205552816391,
-0.0068026939406991005,
0.0021238885819911957,
-0.015746034681797028,
-0.08139045536518097,
0.0033160019665956497,
0.025756554678082466,
-0.015388842672109604,
0.007332727313041687,
0.004558277316391468,
0.019870290532708168,
-0.020282775163650513,
0.026311581954360008,
-0.01078345812857151,
0.011767505668103695,
-0.0047685871832072735,
0.00904526375234127,
0.011615083552896976,
0.003859373275190592,
-0.008722136728465557,
0.0022170967422425747,
-0.009395758621394634,
-0.0008593267994001508,
0.03155225142836571,
-0.01672806218266487,
0.018088212236762047,
-0.010705496184527874,
0.0009370592888444662,
-0.010835869237780571,
-0.028873035684227943,
-0.007382519543170929,
0.013525223359465599,
-0.0027260552160441875,
-0.022203370928764343,
-0.0032836822792887688,
0.0026115213986486197,
-0.010769614949822426,
-0.040925271809101105,
-0.004969709552824497,
-0.01288684457540512,
0.000636048149317503,
0.0075478702783584595,
-0.015985233709216118,
-0.021832333877682686,
0.0017648932989686728,
0.013100508600473404,
0.01878550834953785,
0.011864273808896542,
-0.0361129567027092,
0.0029258360154926777,
0.006202763877809048,
-0.017892567440867424,
0.015606884844601154,
-0.029002932831645012,
0.0060806311666965485,
-0.012560807168483734,
-0.014936058782041073,
0.03858266770839691,
-0.002523654606193304,
0.015843836590647697,
-0.0010864685755223036,
0.01664685271680355,
0.003091565566137433,
0.0011713302228599787,
0.007323023397475481,
0.01798492856323719,
-0.014512811787426472,
0.07178719341754913,
-0.009527190588414669,
0.01896638050675392,
-0.0019074366427958012,
-0.008006012067198753,
0.007144375704228878,
-0.000924794003367424,
0.025532474741339684,
-0.008178580552339554,
-0.044578198343515396,
0.007875930517911911,
-0.01539532095193863,
0.003106198273599148,
0.015365086495876312,
0.02200198546051979,
0.0003410708159208298,
0.004788986407220364,
0.016680583357810974,
-0.010975431650876999,
0.024994295090436935,
0.004156863316893578,
0.0026139342226088047,
0.0025478762108832598,
-0.026347320526838303,
0.00904882326722145,
0.0042544142343103886,
0.00999445654451847,
0.006839067675173283,
0.006561029702425003,
0.009830070659518242,
-0.012312655337154865,
0.0011883806437253952,
-0.000933305302169174,
0.009501686319708824,
0.030820904299616814,
-0.0010054358281195164,
0.0040758103132247925,
0.01442357525229454,
-0.00675753690302372,
0.010686728172004223,
-0.002139896620064974,
0.0032308141235262156,
-0.009208141826093197,
-0.017146389931440353,
0.04052908718585968,
0.0019327729241922498,
0.02327984757721424,
0.020920436829328537,
-0.0007614903151988983,
-0.009951304644346237,
-0.011695755645632744,
0.01162585150450468,
-0.009309999644756317,
-0.017565205693244934,
0.021529145538806915,
0.00011356687173247337,
-0.019043153151869774,
0.008546767756342888,
0.019376616925001144,
0.002053662668913603,
0.004972912836819887,
-0.0183323435485363,
-0.02590932324528694,
-0.02452641725540161,
0.026509998366236687,
-0.01608430966734886,
0.032875265926122665,
-0.02321670576930046,
-0.008419509045779705,
0.015497801825404167,
-0.042348265647888184,
-0.004330974072217941,
0.012474553659558296,
0.022310875356197357,
0.03519237041473389,
0.006699919700622559,
-0.005846268497407436,
-0.018159346655011177,
0.03167123347520828,
0.006654167082160711,
-0.01589111238718033,
-0.029707133769989014,
0.012321068905293941,
-0.01091078668832779,
0.010850677266716957,
0.0054252976551651955,
-0.0172315314412117,
-0.007887354120612144,
0.003288181498646736,
0.009714795276522636,
0.015273960307240486,
0.02257886715233326,
0.005519273690879345,
-0.009324779734015465,
0.008567693643271923,
0.03277638927102089,
-0.020854968577623367,
0.009884879924356937,
0.000758834183216095,
-0.013128478080034256,
0.014669486321508884,
-0.010134376585483551,
0.0067259869538247585,
0.0033197342418134212,
0.016535358503460884,
0.000850541633553803,
0.007695001550018787,
-0.007957695052027702,
0.0054206764325499535,
0.030539659783244133,
0.013072768226265907,
0.0007919147610664368,
-0.0012889597564935684,
0.004790441133081913,
-0.008820666000247002,
0.01158271636813879,
-0.016573533415794373,
-0.005604023113846779,
-0.0014195493422448635,
-0.011889264918863773,
-0.007995927706360817,
-0.00782863050699234,
0.024904413148760796,
0.011842774227261543,
-0.037532344460487366,
-0.01707271859049797,
-0.014290114864706993,
0.027264300733804703,
0.010763710364699364,
-0.023595253005623817,
0.01161712035536766,
0.013145536184310913,
0.0017620145808905363,
-0.00490751676261425,
0.01588183455169201,
0.011570287868380547,
0.016092956066131592,
-0.010110861621797085,
-0.008415834046900272,
-0.02722536399960518,
0.005156605504453182,
-0.009231197647750378,
0.0002556870458647609,
0.005669929087162018,
0.008963442407548428,
-0.015415354631841183,
0.016780443489551544,
0.00666453130543232,
0.005064374767243862,
-0.009890475310385227,
-0.0028217649087309837,
0.005753243807703257,
0.009913587011396885,
-0.013360990211367607,
0.045781590044498444,
0.000015258672647178173,
-0.0027326925192028284,
-0.014697880484163761,
0.020044218748807907,
0.017901349812746048,
0.02548406645655632,
0.02668452262878418,
0.046242356300354004,
-0.0029519882518798113,
0.007132795639336109,
0.006482288241386414,
0.014484822750091553,
-0.0024134074337780476,
-0.010681694373488426,
0.023504721000790596,
0.025931160897016525,
0.009012063965201378,
0.012692422606050968,
0.013352762907743454,
-0.001666568685323,
-0.017491886392235756,
-0.020653430372476578,
0.017956234514713287,
0.020512131974101067,
0.02090708538889885,
0.003387711476534605,
-0.030094780027866364,
0.005124276969581842,
-0.008675074204802513,
0.0026678761932998896,
0.02752506732940674,
-0.00598175311461091,
0.0011835363693535328,
0.002472053514793515,
0.0012118523009121418,
-0.015929153189063072,
0.017400287091732025,
-0.002762187272310257,
0.027206527069211006,
-0.012020692229270935,
-0.004870397038757801,
-0.025440309196710587,
-0.012621644884347916,
0.014775983989238739,
0.004624505527317524,
0.015436635352671146,
-0.02980961464345455
] | [
0.02605273388326168,
0.06879372149705887,
0.1589580923318863,
-0.2724684476852417,
0.01677904650568962,
-0.017935018986463547,
0.4919508099555969,
0.33726200461387634,
-0.5667421817779541,
-0.46586135029792786,
-0.09387180954217911,
0.0949469730257988,
-0.3140406608581543,
0.3441656231880188,
-0.009360656142234802,
0.6194749474525452,
0.557286262512207,
0.44247081875801086,
-0.30407020449638367,
-0.6056122183799744,
-0.11316975206136703,
-0.2251480370759964,
0.5593755841255188,
-0.02780388668179512,
0.02867002598941326,
-0.04523267224431038,
0.5579833984375,
-0.1899581253528595,
0.359859824180603,
-0.12375437468290329,
-0.7016586661338806,
0.1594873070716858,
0.4546305537223816,
0.18115611374378204,
0.015505049377679825,
-0.2693675756454468,
-0.4103364050388336,
0.019870949909090996,
0.28753572702407837,
0.6761104464530945,
-0.09067948907613754,
-0.47688028216362,
-0.21291211247444153,
0.3545680344104767,
-0.18987448513507843,
-0.6667807698249817,
-1.2342228889465332,
1.0305418968200684,
-0.2219468504190445,
0.2393941581249237,
-0.339846134185791,
0.18040359020233154,
-0.2398192137479782,
0.06963759660720825,
0.20466813445091248,
0.23079505562782288,
-0.4409026503562927,
-0.23380903899669647,
0.5239070653915405,
-0.8347958326339722,
0.06382475793361664,
-0.16326871514320374,
-0.47067204117774963,
0.43251660466194153,
-0.5760679841041565,
0.7715137600898743,
0.05734722316265106,
-0.05045148730278015,
-0.8029024600982666,
-0.5341123342514038,
0.08062881976366043,
0.0806761085987091,
-0.4852547347545624,
-0.011721965856850147,
0.29108837246894836,
-0.11924930661916733,
-0.1434972733259201,
-0.24790239334106445,
0.15047357976436615,
-0.16984868049621582,
-0.296335369348526,
0.2962963581085205,
0.05276075750589371,
0.10689094662666321,
0.35192835330963135,
0.06656493246555328,
-0.11805930733680725,
0.6512884497642517,
-0.1557525396347046,
-0.46091824769973755,
0.07620406150817871,
-0.2632789611816406,
0.13250119984149933,
0.5068464875221252,
-0.05804087594151497,
0.4686824679374695,
-0.124668188393116,
-0.019328488036990166,
0.22125929594039917,
-0.1870013028383255,
-0.33870729804039,
-0.03998854011297226,
0.11014582216739655,
-0.29227080941200256,
-0.609347403049469,
-0.14010252058506012,
-0.04565424472093582,
-0.6356214284896851,
-0.41401347517967224,
0.01993214152753353,
-0.6814203262329102,
-0.2215745449066162,
-0.49909523129463196,
-0.08064977824687958,
-0.03286462649703026,
-0.05999928340315819,
0.16435344517230988,
-0.8621875047683716,
-0.06017013266682625,
-0.053794194012880325,
-0.46842145919799805,
0.9270174503326416,
-0.3868224024772644,
0.7120695114135742,
-0.04762275889515877,
-0.33380308747291565,
-0.298841655254364,
0.059680089354515076,
-0.413997083902359,
0.48723506927490234,
0.49797406792640686,
0.6804842948913574,
-0.33694759011268616,
0.4704727232456207,
0.03419020399451256,
0.23252280056476593,
0.18656080961227417,
0.3544512689113617,
0.20213431119918823,
0.009880849160254002,
-0.84233558177948,
-0.1364639550447464,
-0.41391685605049133,
0.20940347015857697,
0.1612396091222763,
-0.3206789493560791,
-0.4039210081100464,
-0.21552428603172302,
-0.24617457389831543,
-0.04780106619000435,
0.16837966442108154,
-0.7113842964172363,
-0.3357442021369934,
-0.16610994935035706,
-0.09379362314939499,
0.11057917028665543,
0.5222866535186768,
0.20602256059646606,
-0.07152892649173737,
0.27651670575141907,
0.5053333044052124,
-0.013367420062422752,
-0.6210423111915588,
-0.1658281534910202,
0.2606434226036072,
0.19171151518821716,
0.6841576099395752,
0.43032392859458923,
-0.0123363696038723,
-0.34618115425109863,
-0.13177244365215302,
-0.4622986614704132,
0.6314347982406616,
-0.7068908214569092,
-0.3027203679084778,
-0.002676580334082246,
0.44970306754112244,
-0.1404787302017212,
0.42352864146232605,
-0.1172272115945816,
-0.6851264238357544,
-0.5021034479141235,
-0.3483599126338959,
-0.2794523537158966,
0.2591325342655182,
-0.0385189950466156,
0.2516896426677704,
-0.1631963551044464,
-0.34094464778900146,
-0.2449599951505661,
-0.380128413438797,
-0.2626451849937439,
0.7469865083694458,
-0.49390652775764465,
1.220723032951355,
-0.28110867738723755,
-0.08424797654151917,
1.5272674560546875,
0.4736376106739044,
0.17414136230945587,
-0.3621671497821808,
-0.2313237190246582,
0.6160119771957397,
-0.09750404953956604,
-0.4284060299396515,
0.3741952180862427,
0.07379352301359177,
0.16730821132659912,
0.34693482518196106,
0.06489424407482147,
0.1767537146806717,
-0.3694501221179962,
-0.13673347234725952,
-0.07390722632408142,
0.3020034432411194,
0.040254928171634674,
-0.16808255016803741,
-0.582312285900116,
-0.3288269639015198,
0.19738872349262238,
0.09450315684080124,
-0.7680097222328186,
0.778034508228302,
0.29148828983306885,
-0.42018505930900574,
0.7068144679069519,
0.4603119194507599,
0.20079711079597473,
0.6608506441116333,
-0.15595558285713196,
0.06300244480371475,
-0.2526475191116333,
0.34458521008491516,
-0.3170766234397888,
-0.3229290843009949,
0.18810845911502838,
0.3806324899196625,
0.3405038118362427,
-0.07333973795175552,
-0.028454454615712166,
-0.14288249611854553,
0.7990964651107788,
-0.5753059387207031,
-0.2392977923154831,
-0.09698118269443512,
-0.3940850794315338,
-0.18213704228401184,
0.18283607065677643,
-0.36423593759536743,
-0.06723753362894058,
0.0820164680480957,
-0.047967273741960526,
0.2589540183544159,
-0.4959273040294647,
0.3097873330116272,
0.16444215178489685,
-0.2431481033563614,
-0.2156057357788086,
0.4800403416156769,
-0.4223824441432953,
-0.19862450659275055,
-0.16230356693267822,
-0.21994450688362122,
0.31436148285865784,
-0.3232676386833191,
-0.07493161410093307,
-0.3506474494934082,
-0.25090983510017395,
1.1177505254745483,
0.7260453701019287,
0.45559489727020264,
-0.20014382898807526,
-0.7996549010276794,
-0.13284865021705627,
0.34848496317863464,
-0.4466833174228668,
0.05505910888314247,
0.6536543965339661,
-0.25958454608917236,
-0.6628584861755371,
-0.5658287405967712,
-0.20021016895771027,
0.9348578453063965,
-0.24446217715740204,
-0.2834809422492981,
-0.2041221708059311,
-0.3473155200481415,
-0.1625053584575653,
-0.287168949842453,
-0.7106195092201233,
-0.39938628673553467,
0.4065626859664917,
0.025721019133925438,
0.23773448169231415,
0.2105482816696167,
0.38964855670928955,
-0.10298876464366913,
0.2485417276620865,
0.7134382724761963,
-0.07614107429981232,
-0.02358349971473217,
0.03894948214292526,
-0.32388606667518616,
-0.00205427804030478,
0.12304820865392685,
0.3256971836090088,
-0.08602788299322128,
0.19637221097946167,
-5.924529075622559,
0.055323924869298935,
-0.11469897627830505,
-0.564797043800354,
0.24032504856586456,
0.029473483562469482,
0.7647867202758789,
0.14680898189544678,
0.7311664819717407,
-0.24358992278575897,
0.3427405059337616,
0.05771809443831444,
-0.2636038661003113,
0.07108744233846664,
-0.3575426936149597,
0.06362798810005188,
0.36186209321022034,
0.1492638885974884,
0.47645142674446106,
-0.010672122240066528,
0.28652289509773254,
0.04485100135207176,
-0.0756828710436821,
-0.3098917603492737,
0.24512767791748047,
0.16255132853984833,
-1.158595323562622,
0.05571211501955986,
-0.11757663637399673,
-0.3502146601676941,
-0.04584065079689026,
-0.528327465057373,
0.15654228627681732,
-0.2141367793083191,
-0.011596646159887314,
-0.3687089681625366,
-0.043042685836553574,
-0.30587026476860046,
0.021183770149946213,
-0.04363240674138069,
0.5327004790306091,
0.27931898832321167,
0.3201410472393036,
-0.06008828431367874,
0.37728965282440186,
-0.06366574764251709,
-0.3816778361797333,
-0.3547559082508087,
-0.0075059738010168076,
0.8371390104293823,
-0.404811292886734,
-0.25736427307128906,
0.2729942202568054,
0.36228835582733154,
0.7090208530426025,
-0.04789339751005173,
-0.3859642744064331,
-0.056090593338012695,
-0.5264748334884644,
-0.32431164383888245,
-0.22027866542339325,
-0.45241838693618774,
-0.22688470780849457,
-0.8354989886283875,
0.1041846051812172,
0.18367430567741394,
-0.6215126514434814,
-0.01060174684971571,
0.6991906762123108,
-0.2869183123111725,
-0.4356025755405426,
0.20606981217861176,
-0.25093579292297363,
-0.647564709186554,
0.4446377754211426,
-0.11842664331197739,
-0.29049184918403625,
0.003200822975486517,
-0.3068503737449646,
-0.7053236961364746,
-0.45679885149002075,
-0.03077181614935398,
-0.06328608095645905,
-0.10083962231874466,
0.29619237780570984,
-0.3913511335849762,
0.048234522342681885,
-0.022976279258728027,
-0.22340969741344452,
0.5003775954246521,
0.7241078019142151,
-0.21737773716449738,
-0.05350976437330246,
0.3764244318008423,
0.31297776103019714,
0.42937055230140686,
0.34946975111961365,
0.5724983811378479,
0.39572688937187195,
0.3071807622909546,
0.4071016311645508,
-0.4536389112472534,
-0.418244332075119,
-0.7541393637657166,
-0.263076514005661,
0.6324095726013184,
-0.49855345487594604,
0.23471428453922272,
0.4593760073184967,
-0.6144461035728455,
0.015610753558576107,
0.05798134580254555,
-0.32710000872612,
0.11224770545959473,
0.5010888576507568,
-0.31499963998794556,
0.08379524946212769,
0.05918923765420914,
0.6934271454811096,
-0.5514625310897827,
-0.023111730813980103,
0.7806540727615356,
-0.6133970618247986,
0.47909075021743774,
-0.3693123757839203,
-0.4435727298259735,
0.14260366559028625,
0.47503897547721863,
-0.482796311378479,
-0.2507036328315735,
-0.0031972427386790514,
0.36805713176727295,
-0.3256978988647461,
-0.5171771049499512,
0.4042403995990753,
-0.25239720940589905,
0.015699556097388268,
0.38912850618362427,
0.3053455054759979,
-0.24112561345100403,
0.16310261189937592,
-0.24498774111270905,
0.15641970932483673,
0.10960541665554047,
-0.30517104268074036,
0.3524355888366699,
0.3983936607837677,
0.38849449157714844,
-0.2755037546157837,
-0.27347317337989807,
0.2797180414199829,
-0.2980380356311798,
0.16508859395980835,
-0.08020257949829102,
-0.2923664152622223,
0.30471980571746826,
0.21237580478191376,
0.19061167538166046,
0.5679718852043152,
-0.16694781184196472,
0.1858139932155609,
0.07687168568372726,
-0.30766892433166504,
0.2130780965089798,
-0.034261785447597504,
-0.5472620725631714,
0.29246363043785095,
-0.7862200736999512,
-0.25611212849617004,
0.40187564492225647,
-0.4250647723674774,
-0.061258599162101746,
0.39404821395874023,
-0.001699715619906783,
0.14018340408802032,
-0.03569655492901802,
-0.018898917362093925,
-0.10019582509994507,
-0.27630722522735596,
0.44693082571029663,
0.2942349910736084,
0.0314381942152977,
-0.2543894648551941,
0.508560299873352,
0.6682478785514832,
0.10333720594644547,
0.12333913147449493,
-0.42106202244758606,
-0.10344578325748444,
-0.4823720455169678,
0.2755860984325409,
0.030723262578248978,
0.25513312220573425,
-0.6096198558807373,
0.16304200887680054,
0.3533114790916443,
0.09571628272533417,
0.6325492262840271,
0.040639907121658325,
-0.36076128482818604,
0.058120615780353546,
0.44789430499076843,
-0.4622589945793152,
0.3216203451156616,
0.2558218538761139,
0.15322266519069672,
-0.09557823091745377,
-0.4764152765274048,
0.12599775195121765,
-0.26726043224334717,
-0.10192473232746124,
-0.4318294823169708,
-0.044003766030073166,
0.22809138894081116,
-0.0594000481069088,
-0.08681681007146835,
0.07448332756757736,
-0.06501752138137817,
-0.2412446290254593,
0.3142121732234955,
0.011425566859543324,
0.15075573325157166,
0.1536387801170349,
0.07019561529159546,
-0.13386771082878113,
0.5398714542388916,
0.25137200951576233,
-0.8148080706596375,
0.2937591075897217,
-0.03665619343519211,
0.3597915470600128,
-0.5823310017585754,
0.3280788064002991,
0.11749131232500076,
-0.6270052194595337,
-0.7242341637611389,
-0.016944533213973045,
0.1376611292362213,
0.17159385979175568,
0.8049827218055725,
0.6613749265670776,
0.35098621249198914,
-0.30757269263267517,
-0.13289621472358704,
-0.6863880157470703,
0.17958085238933563,
0.11771935224533081,
-0.44518721103668213,
-0.2116360068321228,
0.4190158247947693,
0.26220908761024475,
-0.06516598165035248,
0.07437960058450699,
0.4917951226234436,
0.8625108003616333,
0.05519358068704605,
-0.38882866501808167,
-0.15247224271297455,
-0.2705143392086029,
0.1853221207857132,
0.10668729990720749,
-0.26340779662132263,
-0.2423332780599594,
0.009093178436160088,
-0.23073337972164154,
0.10076923668384552,
-0.33372682332992554,
-0.46814265847206116,
0.40664568543434143,
0.3437422215938568,
-0.2807648181915283,
-0.019912777468562126,
0.6168860197067261,
0.295400470495224,
-0.23348841071128845,
0.2776326537132263,
-0.29233548045158386,
0.5309627056121826,
-0.05197518318891525,
0.26892971992492676,
-0.21905748546123505,
-0.4557097852230072,
0.5300429463386536,
-0.4028792083263397,
0.4296354651451111,
-0.6899084448814392,
0.18239803612232208,
-0.35574814677238464,
0.32084792852401733,
-0.20623734593391418,
-0.6639154553413391,
-0.003912934567779303,
-0.764742374420166,
-0.557228147983551,
0.15435689687728882,
-0.1954105943441391,
0.17168493568897247,
0.21362365782260895,
-0.06645918637514114,
-0.0490703284740448,
-0.5548477172851562,
0.2476547658443451,
0.6537036895751953,
-0.6479681134223938,
-0.22329114377498627,
0.14022581279277802,
-0.2632761299610138,
0.041111964732408524,
-0.7901654839515686,
0.16180728375911713,
-0.1478404998779297,
0.24027658998966217,
0.5301560163497925,
-0.2342851161956787,
-0.22526726126670837,
0.09195419400930405,
-0.25682780146598816,
-0.27513429522514343,
0.02826809138059616,
0.0335049070417881,
0.4367392063140869,
0.8179861307144165,
0.1784507930278778,
0.16663013398647308,
0.11925451457500458,
0.8340604305267334,
0.07923157513141632,
-0.014467122033238411,
-0.08335967361927032,
0.2917310297489166,
0.16256685554981232,
-0.23965269327163696,
0.157954141497612,
0.6409755349159241,
-0.006991192232817411,
0.09044137597084045,
0.2722732126712799,
-0.640055239200592,
0.21129322052001953,
-0.0038159058894962072,
0.611267626285553,
0.8042408227920532,
-0.3326781392097473,
-0.597567081451416,
0.37638920545578003,
-0.005393891129642725,
0.2825101613998413,
-0.11526498198509216,
0.0912812352180481,
0.5481871962547302,
0.37185531854629517,
-1.1047269105911255,
-0.44343429803848267,
0.26270943880081177,
-0.46248289942741394,
0.02337174490094185,
0.09297468513250351,
-0.46016639471054077,
-0.649467945098877,
0.13718685507774353,
0.006956611759960651,
0.48799294233322144,
0.03891792520880699,
0.718788743019104,
-0.0649222880601883,
-0.2277728021144867,
0.5944679379463196,
0.5439954400062561,
0.44260504841804504,
-0.290066659450531,
0.055476561188697815,
0.1293211430311203,
-0.1187819391489029,
0.17274053394794464,
0.08028022944927216,
-0.043042443692684174,
0.3221012353897095,
0.1225522831082344,
-0.3477105498313904,
0.036751631647348404,
-0.2727413475513458,
0.29462629556655884,
-0.12192719429731369,
-0.33182114362716675,
-0.17642520368099213,
-0.19484947621822357,
0.049046631902456284,
-0.3246581256389618,
-0.3513748347759247,
-0.21644531190395355,
0.019328098744153976,
-0.8720982074737549,
-0.30723726749420166,
0.16493794322013855,
-0.2240513563156128,
-0.07439406961202621,
0.27777227759361267,
0.3870983123779297,
0.39709383249282837,
0.9417718648910522,
0.20896564424037933,
-0.223833829164505,
0.041152313351631165,
0.7484186291694641,
-0.4245516061782837,
0.4702170491218567,
-0.2127760499715805,
-0.26239994168281555,
-0.3557206988334656,
-0.16373853385448456,
1.4249368906021118,
1.0524042844772339,
-0.1671571433544159,
0.2435990571975708,
0.508980393409729,
0.045487768948078156,
0.04081620275974274,
-0.4396366775035858,
0.25536778569221497,
-0.2789955139160156,
-0.24521960318088531,
-0.5439306497573853,
0.7510408163070679,
0.3858518898487091,
-0.3576025664806366,
-0.12499110400676727,
0.6107821464538574,
0.42872104048728943,
-0.3382573127746582,
0.15955223143100739,
-0.5254237651824951,
-0.09783056378364563,
-0.2934023439884186,
0.3922545909881592,
-0.3512711524963379,
0.06172061339020729,
-0.2610381841659546,
0.4436998665332794,
0.17571419477462769,
-0.166243776679039,
0.12260174006223679,
-0.16016890108585358,
0.11319097876548767,
0.24296706914901733,
-0.027194730937480927,
0.21210305392742157,
-0.1680518388748169,
-0.5512987375259399,
-0.5323959589004517,
-0.19596092402935028,
-0.027846284210681915,
-0.0514524020254612,
-0.24760505557060242,
0.20634104311466217,
-0.132058247923851,
-0.31065282225608826,
0.4108908772468567,
-0.05715518817305565,
0.17341530323028564,
0.16013570129871368
] |
Ribosomal frameshifting on viral RNAs relies on the mechanical properties of structural elements, often pseudoknots and more rarely stem-loops, that are unfolded by the ribosome during translation. In human immunodeficiency virus (HIV)-1 type B a long hairpin containing a three-nucleotide bulge is responsible for efficient frameshifting. This three-nucleotide bulge separates the hairpin in two domains: an unstable lower stem followed by a GC-rich upper stem. Toeprinting and chemical probing assays suggest that a hairpin-like structure is retained when ribosomes, initially bound at the slippery sequence, were allowed multiple EF-G catalyzed translocation cycles. However, while the upper stem remains intact the lower stem readily melts. After the first, and single step of translocation of deacylated tRNA to the 30 S P site, movement of the mRNA stem-loop in the 5′ direction is halted, which is consistent with the notion that the downstream secondary structure resists unfolding. Mechanical stretching of the hairpin using optical tweezers only allows clear identification of unfolding of the upper stem at a force of 12.8 ± 1.0 pN. This suggests that the lower stem is unstable and may indeed readily unfold in the presence of a translocating ribosome. | [
-0.012310000136494637,
0.01811707392334938,
-0.011670497246086597,
0.017471374943852425,
0.01226728968322277,
-0.019539572298526764,
0.01089950930327177,
0.017039403319358826,
-0.016979075968265533,
0.005029603373259306,
-0.010287096723914146,
0.007683138828724623,
-0.02552836388349533,
0.01564321294426918,
0.0004210537299513817,
-0.01616314798593521,
-0.026633314788341522,
-0.006756816059350967,
0.013294782489538193,
0.009919448755681515,
0.02704591490328312,
-0.01570899784564972,
0.011252187192440033,
-0.0011120636481791735,
0.00020000804215669632,
-0.004771076608449221,
0.004438835196197033,
-0.007931480184197426,
0.030260629951953888,
0.021937012672424316,
0.012637198902666569,
0.0047335438430309296,
0.016343431547284126,
0.02241237834095955,
0.010875796899199486,
0.044457659125328064,
-0.007998657412827015,
0.03281733766198158,
0.05655297636985779,
-0.0056214360520243645,
-0.008614064194262028,
-0.015076291747391224,
0.0026520921383053064,
-0.009462698362767696,
-0.007376162335276604,
0.004779616370797157,
0.004399605095386505,
0.009447123855352402,
-0.003919302485883236,
0.000810708908829838,
-0.018060222268104553,
-0.01985371857881546,
-0.012180360965430737,
0.02796538546681404,
-0.0064218430779874325,
-0.04952221363782883,
0.017411768436431885,
0.008489754050970078,
-0.03548426926136017,
0.006697020959109068,
-0.015008816495537758,
0.022934220731258392,
0.00858608353883028,
0.005421321839094162,
0.00823324453085661,
-0.06685863435268402,
0.01806352287530899,
-0.0002712933346629143,
0.0035267560742795467,
0.0005045547150075436,
0.004554989747703075,
0.005919933319091797,
0.022521711885929108,
-0.011088946834206581,
-0.03872963413596153,
-0.0028832214884459972,
-0.009686250239610672,
0.03023618832230568,
-0.009636344388127327,
0.008388089016079903,
0.00985077116638422,
0.010208507999777794,
0.014266740530729294,
0.012994170188903809,
-0.006735439877957106,
0.00521403132006526,
-0.03036605380475521,
0.009181827306747437,
0.004043828696012497,
-0.003727629780769348,
0.01912509836256504,
0.0003182630753144622,
-0.007376482244580984,
0.02218419685959816,
0.025654291734099388,
-0.021891724318265915,
-0.022384628653526306,
-0.026063188910484314,
0.02029241994023323,
-0.016428299248218536,
-0.01689014956355095,
0.03442375361919403,
0.01313022617250681,
-0.0011539272964000702,
0.010233258828520775,
0.006741597317159176,
0.042174115777015686,
0.02320392057299614,
0.030575068667531013,
0.010674679651856422,
-0.023359492421150208,
0.016719462350010872,
0.016325708478689194,
-0.011712221428751945,
-0.00015066447667777538,
-0.0005638403818011284,
-0.022707633674144745,
0.028857804834842682,
0.010977659374475479,
0.0017924706917256117,
0.021516192704439163,
0.0047337934374809265,
-0.0015760913956910372,
-0.020656194537878036,
0.0048378542996943,
-0.037468187510967255,
-0.02518005296587944,
0.001846706261858344,
0.0022623317781835794,
0.00019195361528545618,
-0.010185770690441132,
0.021201234310865402,
-0.02471448853611946,
-0.015349974855780602,
0.001758116646669805,
0.0015266066184267402,
-0.018082212656736374,
-0.007456185761839151,
0.016235802322626114,
0.0010331741068512201,
0.012479543685913086,
0.0027629821561276913,
0.007426075637340546,
0.014867798425257206,
0.009809665381908417,
0.0077042668126523495,
-0.025291327387094498,
0.001286136917769909,
0.01872791349887848,
-0.02693362720310688,
0.013855652883648872,
0.002420123666524887,
-0.007131827995181084,
-0.014661011286079884,
0.005071916617453098,
0.0040385108441114426,
-0.0355166420340538,
-0.034037135541439056,
0.00034612230956554413,
0.013601204380393028,
0.0003724844427779317,
-0.010016269981861115,
-0.00964029598981142,
0.011585055850446224,
0.022548288106918335,
-0.03745012730360031,
0.015426474623382092,
-0.010393388569355011,
-0.0024711452424526215,
0.009671335108578205,
-0.009843365289270878,
0.0243359487503767,
0.028452418744564056,
0.0154634490609169,
0.006956841330975294,
-0.0007052314467728138,
0.001259561162441969,
0.008653722703456879,
-0.015249909833073616,
0.0662374198436737,
-0.033265046775341034,
0.01695786416530609,
-0.006830369122326374,
0.006435736082494259,
0.02263515815138817,
-0.0018888907507061958,
-0.004498152062296867,
-0.008211418054997921,
0.014762680977582932,
0.010132256895303726,
0.023257838562130928,
0.012675011530518532,
-0.003036752576008439,
0.01686222106218338,
0.018084004521369934,
0.003936383407562971,
0.019328992813825607,
0.012246286496520042,
0.006460363045334816,
0.013227971270680428,
0.028036611154675484,
-0.009653393179178238,
-0.004034996032714844,
-0.02114509791135788,
-0.030483685433864594,
0.006783629767596722,
0.01477115973830223,
-0.017051592469215393,
-0.017946384847164154,
-0.024001721292734146,
0.019497841596603394,
-0.014030270278453827,
0.007606439292430878,
-0.008464647457003593,
-0.009198724292218685,
-0.0027765342965722084,
-0.006678888574242592,
0.022982288151979446,
0.006385699845850468,
-0.012913467362523079,
0.009467370808124542,
-0.0008381013758480549,
-0.03323576971888542,
-0.007357167080044746,
0.007941500283777714,
-0.004953242372721434,
0.001885028905235231,
0.01219429261982441,
-0.018881067633628845,
0.01619449444115162,
0.007834568619728088,
-0.024566650390625,
-0.015870926901698112,
-0.0027100713923573494,
0.02251937799155712,
-0.04640303552150726,
0.01399278361350298,
-0.01957256719470024,
0.007436951622366905,
-0.014766078442335129,
-0.016875315457582474,
-0.0004246579483151436,
0.015423433855175972,
-0.0386931411921978,
0.012038666754961014,
-0.0011750143021345139,
-0.011750521138310432,
0.007359890732914209,
0.00885448046028614,
-0.020230425521731377,
0.013199427165091038,
0.01158061996102333,
-0.013511555269360542,
0.016893848776817322,
0.01712159812450409,
-0.001549074426293373,
0.00009020045399665833,
0.012512210756540298,
0.023936007171869278,
0.0072208247147500515,
0.0009854586096480489,
0.007714412175118923,
-0.008184066973626614,
-0.01926058903336525,
-0.015501180663704872,
-0.00585697777569294,
0.026643112301826477,
0.01440482959151268,
0.004448284860700369,
0.005225724540650845,
0.010296229273080826,
-0.016788125038146973,
0.0003363139694556594,
-0.08094988763332367,
-0.021280549466609955,
-0.0013376744464039803,
-0.002346781548112631,
0.0031581155490130186,
-0.004415521398186684,
-0.020350174978375435,
0.004678815603256226,
-0.008159798569977283,
-0.01536852028220892,
0.006349561735987663,
0.021307460963726044,
-0.013771284371614456,
-0.005107046104967594,
0.0130976103246212,
-0.015078860335052013,
0.019912421703338623,
-0.028066560626029968,
-0.014510546810925007,
-0.02107878588140011,
-0.03701731190085411,
-0.018007533624768257,
-0.002453369088470936,
0.015311406925320625,
-0.04352102428674698,
0.02234571985900402,
0.0058252811431884766,
-0.0014551545027643442,
-0.0009711517486721277,
0.004182312171906233,
-0.004095977172255516,
-0.01667376048862934,
0.004618311300873756,
-0.012880148366093636,
0.026835642755031586,
0.02340075746178627,
-0.036745619028806686,
-0.008986839093267918,
-0.015625901520252228,
0.023008011281490326,
-0.015623539686203003,
0.002530038822442293,
0.002592792734503746,
0.017992792651057243,
0.0030135768465697765,
-0.0037987385876476765,
-0.0006897224811837077,
0.012288223020732403,
0.02646561712026596,
0.007637379691004753,
-0.025459621101617813,
-0.006235039792954922,
0.015671882778406143,
0.018541308119893074,
-0.0056805480271577835,
-0.004016931168735027,
-0.034715693444013596,
-0.009221907705068588,
-0.012459678575396538,
-0.01571926474571228,
0.020436417311429977,
0.019286975264549255,
0.0396619588136673,
-0.016385376453399658,
-0.022035470232367516,
0.027466313913464546,
0.010709220543503761,
-0.014782927930355072,
-0.008259630762040615,
0.014400351792573929,
0.033488936722278595,
-0.01593007519841194,
0.009509633295238018,
-0.011356028728187084,
0.007333219982683659,
-0.0043938010931015015,
-0.014923276379704475,
-0.01596740633249283,
-0.00939994491636753,
-0.010470827110111713,
-0.01184070948511362,
-0.0007145404815673828,
-0.0029674198012799025,
0.007815539836883545,
-0.026373369619250298,
-0.02493632584810257,
0.005952417850494385,
0.010944319888949394,
0.011241612955927849,
-0.019642964005470276,
0.020651880651712418,
0.025562552735209465,
-0.01589226722717285,
0.01667626202106476,
-0.017755785956978798,
-0.027079591527581215,
-0.0014136508107185364,
0.023100484162569046,
0.0068018799647688866,
0.008932205848395824,
-0.03377438336610794,
-0.007130871992558241,
0.03786706179380417,
-0.005406354088336229,
-0.007251981645822525,
0.014584783464670181,
-0.011740349233150482,
-0.008928247727453709,
-0.0017071636393666267,
0.0025800587609410286,
0.021548284217715263,
0.011904744431376457,
-0.01119537279009819,
0.033184029161930084,
0.013890321366488934,
0.010204782709479332,
-0.014916907995939255,
-0.007348800078034401,
0.07188627123832703,
0.011781138367950916,
-0.0003156396560370922,
-0.013587428256869316,
-0.00763260293751955,
-0.010140852071344852,
-0.012728886678814888,
0.004770848900079727,
0.00896728876978159,
-0.00773169519379735,
0.01184940803796053,
-0.032150380313396454,
0.005599180236458778,
0.015028061345219612,
0.033431630581617355,
-0.007666027173399925,
-0.020554400980472565,
-0.0334029421210289,
0.0018740034429356456,
0.03150177374482155,
0.0051302434876561165,
-0.00922341551631689,
0.004347924143075943,
-0.009048267267644405,
-0.010123751126229763,
-0.014438949525356293,
0.018693486228585243,
-0.01634998247027397,
-0.031047487631440163,
0.014597054570913315,
0.004136973526328802,
-0.031769730150699615,
-0.008613962680101395,
-0.006628145929425955,
0.021290507167577744,
-0.014405214227735996,
-0.009858392179012299,
0.024774935096502304,
-0.003562348894774914,
-0.012281815521419048,
0.017868133261799812,
-0.01649525761604309,
-0.013907672837376595,
0.014556379988789558,
0.03325563296675682,
0.012197280302643776,
0.0033015545923262835,
-0.009315221570432186,
-0.0013552154414355755,
-0.010131249204277992,
0.0018805568106472492,
-0.010808674618601799,
0.010985461995005608,
-0.0029737884178757668,
0.0033516231924295425,
-0.0185508131980896,
0.03331981226801872,
-0.02313140779733658,
0.017776748165488243,
0.008385593071579933,
0.004617874510586262,
0.006422556936740875,
0.008787851780653,
-0.012559294700622559,
-0.006782903335988522,
-0.02471279911696911,
0.008240760304033756,
-0.007762891240417957,
-0.01100047305226326,
0.011690469458699226,
0.03717725723981857,
0.02072756551206112,
-0.027488313615322113,
-0.0003805107553489506,
-0.02811286970973015,
-0.003855723887681961,
-0.0034598601050674915,
-0.0026314477436244488,
0.03154014050960541,
-0.005578691139817238,
0.032074328511953354,
0.0185488760471344,
-0.019831929355859756,
-0.02088296413421631,
0.008470856584608555,
-0.01951189711689949,
-0.010315506719052792,
-0.07400043308734894,
-0.015983430668711662,
-0.009263216517865658,
-0.00697022769600153,
0.018849022686481476,
0.011064566671848297,
-0.021311167627573013,
-0.034194719046354294,
-0.02085341513156891,
0.004172986373305321,
0.038018569350242615,
0.010568289086222649,
0.02326357178390026,
-0.03339197486639023,
0.011639402247965336,
0.006235470995306969,
-0.031208429485559464,
0.005573454312980175,
-0.011606225743889809,
0.00637056864798069,
0.014638453722000122,
-0.007071451283991337,
-0.008714049123227596,
-0.019760143011808395,
-0.0038227131590247154,
-0.08100149035453796,
-0.013072981499135494,
0.00417855242267251,
-0.014083828777074814,
-0.01042660791426897,
0.008234946057200432,
-0.03108803555369377,
-0.027057001367211342,
-0.016716230660676956,
-0.019113212823867798,
0.009235035628080368,
-0.00024208822287619114,
-0.005516462493687868,
0.008502026088535786,
0.037792351096868515,
-0.008180838078260422,
0.0048730019479990005,
0.01896863430738449,
-0.00844376441091299,
0.00948757492005825,
-0.00861988216638565,
0.0006249118596315384,
-0.019031543284654617,
-0.004503798671066761,
-0.0034595062024891376,
-0.012295494787395,
-0.03143708035349846,
0.011907640844583511,
-0.016568848863244057,
-0.004581923596560955,
-0.01900659129023552,
0.02285166271030903,
-0.011362936347723007,
-0.031634584069252014,
0.0036644600331783295,
-0.010974845848977566,
0.024717941880226135,
0.0038931509479880333,
-0.005270703230053186,
-0.004547659307718277,
-0.004309514537453651,
0.013792620040476322,
-0.020090170204639435,
0.01816627010703087,
0.015473240986466408,
-0.020617984235286713,
0.006400281563401222,
-0.00887547992169857,
0.01722121424973011,
0.0025021550245583057,
0.013339097611606121,
-0.027726653963327408,
-0.012735191732645035,
-0.003512596245855093,
0.01578790694475174,
-0.019085116684436798,
0.008233381435275078,
0.00824657641351223,
0.0040918029844760895,
0.0015875361859798431,
0.0005704539944417775,
0.013748863711953163,
-0.0075898319482803345,
0.07085318118333817,
-0.008142723701894283,
0.008410627022385597,
0.00616897689178586,
-0.005617422517389059,
0.008437169715762138,
-0.030940072610974312,
0.004618827719241381,
-0.030735284090042114,
-0.031661506742239,
-0.0021304802503436804,
-0.02006649225950241,
-0.022662483155727386,
0.014088264666497707,
0.005442795343697071,
0.01396092213690281,
-0.0028152968734502792,
0.007016414776444435,
-0.02513420395553112,
0.025487184524536133,
-0.011543191969394684,
0.008425822481513023,
0.013614613562822342,
-0.0026448084972798824,
0.005724561866372824,
0.008641478605568409,
-0.029399443417787552,
0.009478414431214333,
-0.011135956272482872,
0.0055789100006222725,
-0.01990458555519581,
0.00003066379576921463,
0.0030872845090925694,
-0.01869300752878189,
0.013231920078396797,
0.017547400668263435,
-0.024537334218621254,
0.010987596586346626,
0.008348817005753517,
0.014345463365316391,
-0.03122597560286522,
0.007527594454586506,
0.004179881885647774,
-0.031282130628824234,
0.022244304418563843,
-0.03386108577251434,
0.033481091260910034,
0.019590653479099274,
-0.020231155678629875,
0.022738413885235786,
0.0021352912299335003,
-0.0005051047774031758,
0.02331073395907879,
0.01013307273387909,
0.01774897426366806,
0.014087438583374023,
0.002209377009421587,
0.013568473979830742,
-0.016307072713971138,
-0.0003554634749889374,
0.011144716292619705,
-0.024846680462360382,
-0.017608340829610825,
-0.02156664989888668,
-0.006388542708009481,
-0.015751129016280174,
0.01760973408818245,
-0.02018866501748562,
-0.017858654260635376,
0.019603412598371506,
-0.021107938140630722,
0.008865760639309883,
0.012682180851697922,
-0.016362037509679794,
0.011050148867070675,
-0.005401689559221268,
0.028228919953107834,
-0.03198561817407608,
0.04619186371564865,
0.0266022477298975,
-0.011680884286761284,
0.010722868144512177,
0.03050054982304573,
0.0031313402578234673,
-0.01816060021519661,
-0.01605009101331234,
-0.015817200765013695,
-0.014821352437138557,
0.0021891663782298565,
0.012500179931521416,
0.008621979504823685,
0.0030312184244394302,
0.004323442466557026,
0.002683144761249423,
0.0007038912735879421,
0.03355253487825394,
0.013674031011760235,
0.008626465685665607,
0.004404336679726839,
-0.0007970586884766817,
0.0075027793645858765,
-0.018284283578395844,
-0.012997716665267944,
0.022965773940086365,
-0.006580576300621033,
-0.012554710730910301,
0.007258129306137562,
0.023831818252801895,
0.019904613494873047,
0.009699936024844646,
0.030782777816057205,
0.004369732458144426,
0.016702421009540558,
-0.0006093954434618354,
0.005368110723793507,
0.03126174211502075,
-0.016834158450365067,
0.005800500046461821,
0.011313177645206451,
-0.010958743281662464,
0.030470475554466248,
0.017162900418043137,
0.02727954089641571,
0.03347720205783844,
-0.014926433563232422,
0.0005886557046324015,
-0.004874161444604397,
0.009375771507620811,
-0.022719353437423706,
-0.01585998199880123,
0.024846317246556282,
-0.033171869814395905,
0.011973557993769646,
0.008946008048951626,
0.02332235872745514,
0.004532794468104839,
-0.004556301981210709,
0.01603403501212597,
0.008032695390284061,
0.021555176004767418,
0.011218871921300888,
-0.026472274214029312,
0.005563182756304741,
0.00719071738421917,
0.008109462447464466,
0.0036120512522757053,
0.011798126623034477,
0.007399985566735268,
0.01250421442091465,
-0.012970257550477982,
-0.00002521788701415062,
0.0037256679497659206,
-0.010427966713905334,
-0.010913904756307602,
-0.02821451984345913,
-0.003015531226992607,
-0.005431716796010733,
-0.03220111504197121,
-0.004909760784357786,
0.012880828231573105,
-0.004603659734129906,
0.05574643984436989,
-0.013252954930067062,
-0.0030266395770013332,
0.022038351744413376,
0.025949370115995407,
0.015693729743361473,
0.0012302277609705925,
-0.005725895054638386,
0.02455168589949608,
0.0035751210525631905,
0.016772588714957237,
0.0020373500883579254,
-0.006921802181750536,
-0.002245422452688217,
-0.018790148198604584,
-0.008104158565402031,
-0.015385108068585396,
-0.015859289094805717,
-0.004444684833288193,
0.016607072204351425,
-0.01374177448451519,
0.006338401231914759,
-0.014187728054821491,
0.010072069242596626,
-0.020215637981891632,
-0.00563570624217391,
-0.007563000079244375,
-0.010657355189323425,
-0.00006639864295721054,
0.0024286750704050064,
0.023377088829874992,
0.003525044536218047,
0.021204272285103798,
0.021356627345085144,
0.010079503059387207,
-0.013468002900481224,
-0.0032368977554142475,
-0.0051365140825510025,
0.00585825415328145,
0.009605568833649158,
0.0006410670466721058
] | [
0.27508607506752014,
0.2928187847137451,
0.27845150232315063,
0.07812359184026718,
-0.19536353647708893,
-0.04721037670969963,
-0.23611341416835785,
-0.38639676570892334,
-0.2799054682254791,
-0.6932929754257202,
0.1517704874277115,
0.10328441113233566,
-0.6287701725959778,
0.28341126441955566,
-0.22427617013454437,
0.470824271440506,
0.25433751940727234,
-0.061464935541152954,
-0.3486936092376709,
-1.0243762731552124,
-0.04886225238442421,
-0.2680955231189728,
0.6163390278816223,
-0.13056021928787231,
0.20738188922405243,
-0.17576314508914948,
0.19027529656887054,
-0.1597837507724762,
0.5438255071640015,
-0.16028521955013275,
0.0655299574136734,
0.13980290293693542,
0.05592392012476921,
-0.014139659702777863,
0.10669295489788055,
-0.47363197803497314,
-0.3524421453475952,
0.07800451666116714,
0.07079026848077774,
-0.24447278678417206,
-0.009808513335883617,
-0.440019428730011,
-0.1316540539264679,
0.29375317692756653,
0.039166685193777084,
-0.9602663516998291,
-1.1471002101898193,
0.9878989458084106,
-0.6542757749557495,
-0.2013118416070938,
-0.6302008628845215,
0.08958081156015396,
0.6599907279014587,
0.23727689683437347,
0.4079895317554474,
0.4351694881916046,
-0.5882343649864197,
-0.21169891953468323,
0.7238802313804626,
-0.6471619606018066,
0.057434890419244766,
0.07810825109481812,
-0.4443948268890381,
0.5189887285232544,
0.11567426472902298,
0.03800993785262108,
-0.04860994964838028,
-0.4369259774684906,
-0.5937798619270325,
-0.4602598249912262,
0.13484510779380798,
-0.341300368309021,
-0.03516359254717827,
0.23254190385341644,
0.1721019595861435,
-0.20162956416606903,
-0.48470380902290344,
0.0000638573183096014,
0.33600714802742004,
-0.6307216882705688,
-0.279358834028244,
0.5213156938552856,
-0.5569993853569031,
-0.030655456706881523,
0.36216017603874207,
0.16189511120319366,
-0.8878670334815979,
0.3161286413669586,
-0.6467867493629456,
0.14485907554626465,
-0.31362074613571167,
-0.25408935546875,
-0.17718593776226044,
0.6068705916404724,
0.26990485191345215,
-0.018284231424331665,
-0.010616703890264034,
0.006849758327007294,
0.5335793495178223,
0.5548837780952454,
-0.2596742808818817,
-0.4296659827232361,
0.6752386093139648,
-0.4085633158683777,
0.04525959491729736,
-0.24358303844928741,
0.13004212081432343,
-0.5351337194442749,
-0.33582308888435364,
-0.0841042548418045,
-0.2647273540496826,
-0.3754972517490387,
-0.44278639554977417,
-0.2103879749774933,
0.4680531620979309,
-0.34304529428482056,
0.22642065584659576,
-0.3235190808773041,
-0.2524762451648712,
0.06384283304214478,
-0.7595221400260925,
1.3011666536331177,
-0.2218686044216156,
-0.12042831629514694,
-0.19060425460338593,
-0.46691304445266724,
0.16049516201019287,
0.3316620886325836,
-0.6971973180770874,
0.004010340664535761,
0.5864118337631226,
1.1656055450439453,
-0.22400882840156555,
0.13829199969768524,
-0.46925532817840576,
0.06262379884719849,
-0.06706853210926056,
0.043136633932590485,
0.38440465927124023,
-0.26640886068344116,
-0.3505782186985016,
-0.3811718225479126,
-0.009066580794751644,
-0.09801264852285385,
0.15801751613616943,
-0.04577445611357689,
0.02825981006026268,
-0.36849939823150635,
-0.4166066348552704,
-0.14257663488388062,
0.20762114226818085,
-0.32575854659080505,
-0.504971981048584,
-0.036977823823690414,
0.13230915367603302,
-0.400646835565567,
0.2976999878883362,
0.2592121660709381,
-0.4401371479034424,
0.34128743410110474,
0.08764112740755081,
-0.27046939730644226,
-0.4328383803367615,
-0.29079917073249817,
0.045710619539022446,
-0.12163028120994568,
1.1278351545333862,
0.8837072849273682,
-0.07926906645298004,
0.0010673870565369725,
-0.05067792162299156,
-0.4619964361190796,
0.26962628960609436,
-0.48403507471084595,
-0.2946414351463318,
0.19936615228652954,
0.20183274149894714,
-0.1825074702501297,
0.10055328160524368,
0.043447185307741165,
-0.5979875326156616,
0.07676845043897629,
-0.09350088983774185,
-0.12860792875289917,
0.39704030752182007,
0.07548172771930695,
0.5815485119819641,
-0.08902960270643234,
-0.44997382164001465,
-0.23329991102218628,
-0.0766262412071228,
-0.28872454166412354,
0.3034725487232208,
-0.4794217050075531,
1.2711801528930664,
0.1582036316394806,
-0.3399050831794739,
1.5663038492202759,
0.1761244535446167,
0.25188738107681274,
-0.6452410221099854,
0.44982126355171204,
0.6078156232833862,
-0.9467229247093201,
-0.5090570449829102,
0.24087373912334442,
0.7279173135757446,
0.052194368094205856,
0.34749963879585266,
-0.002787758829072118,
0.5974230170249939,
-0.34472283720970154,
-0.1835073083639145,
-0.15553529560565948,
0.32436659932136536,
-0.16131670773029327,
0.3431102931499481,
0.1663123369216919,
-0.3737626373767853,
0.33791211247444153,
0.6470732688903809,
-0.6296451091766357,
0.07373042404651642,
0.7475383281707764,
-0.5230194330215454,
0.5444574356079102,
0.5936402678489685,
0.8671898245811462,
0.5469232201576233,
0.025741389021277428,
0.2864215672016144,
-0.8624467849731445,
0.5657994747161865,
-0.24966934323310852,
-0.13296343386173248,
0.13834702968597412,
0.2535840570926666,
0.12656304240226746,
0.20267394185066223,
0.16250824928283691,
-0.07568234205245972,
0.5255938768386841,
-0.7747490406036377,
-0.28728124499320984,
0.21354728937149048,
-0.5747061967849731,
-0.35356026887893677,
0.1600133329629898,
-0.5463758707046509,
-0.4394557476043701,
0.026563184335827827,
0.3998505771160126,
0.42080923914909363,
-0.6916049718856812,
0.15237776935100555,
0.12308180332183838,
-0.23884597420692444,
-0.21412719786167145,
0.7140138745307922,
-0.10655133426189423,
-0.3543771505355835,
-0.30832791328430176,
-0.030129631981253624,
-0.16937735676765442,
-0.6870977878570557,
-0.1466609686613083,
-0.2380235195159912,
-0.4387155771255493,
1.007630467414856,
0.5755628943443298,
0.6314903497695923,
-0.010260947979986668,
-0.8209142088890076,
0.023010557517409325,
-0.07221421599388123,
-0.6858352422714233,
0.4011738896369934,
0.1029231995344162,
-0.035486459732055664,
-0.6341982483863831,
-0.49688720703125,
-0.1266961246728897,
0.8521016836166382,
-0.43008172512054443,
-0.1444593369960785,
-0.03517371416091919,
0.1502363085746765,
-0.09952623397111893,
-0.48520442843437195,
-0.17631255090236664,
-0.6019150018692017,
0.7066333889961243,
-0.49021852016448975,
0.0343761146068573,
0.2157876342535019,
0.9588896632194519,
-0.06547397375106812,
-0.34916603565216064,
0.8897314667701721,
-0.5933642387390137,
0.06894692778587341,
-0.1491113007068634,
-0.3645264804363251,
-0.09654812514781952,
-0.05629381537437439,
0.2835752069950104,
-0.09802919626235962,
0.26222193241119385,
-5.666003704071045,
0.12284954637289047,
-0.3184894919395447,
-0.38143712282180786,
-0.16466054320335388,
-0.1557936817407608,
0.7366068959236145,
-0.32709410786628723,
0.5863723754882812,
-0.46478238701820374,
-0.10542456060647964,
-0.08318062871694565,
-0.09764262288808823,
0.04494041949510574,
0.051107484847307205,
0.4037381410598755,
0.16728836297988892,
0.11251243203878403,
0.41501063108444214,
0.31405624747276306,
0.5435579419136047,
-0.6014750599861145,
0.13964471220970154,
-0.03130509704351425,
-0.12755776941776276,
-0.3746936619281769,
-0.8790624141693115,
-0.1518450528383255,
-0.06486161798238754,
-0.46699193120002747,
-0.024909885600209236,
-0.8359646797180176,
0.4833303987979889,
-0.3215116858482361,
0.23229950666427612,
0.055963385850191116,
0.3827660381793976,
0.10985956341028214,
0.4883437156677246,
-0.08900556713342667,
0.9739364385604858,
0.3304000496864319,
0.40640491247177124,
-0.18064166605472565,
0.4922724664211273,
-0.24145077168941498,
-0.4004874527454376,
-0.0012672110460698605,
-0.061608098447322845,
0.9841310977935791,
0.1639314591884613,
-0.04618273302912712,
0.37819403409957886,
0.06721370667219162,
0.35198137164115906,
-0.10539177060127258,
-0.018409164622426033,
0.01797952689230442,
-0.6190809607505798,
-0.3508077561855316,
0.2951766848564148,
-0.33328530192375183,
-0.407245934009552,
-1.0628230571746826,
0.22352856397628784,
0.047535866498947144,
-0.7970452904701233,
0.31590908765792847,
0.24593552947044373,
0.038158219307661057,
-0.4163082540035248,
0.3268185257911682,
0.024001851677894592,
-0.3115904927253723,
0.8278812170028687,
-0.3562012016773224,
0.459817111492157,
-0.002863784320652485,
-0.1476556956768036,
-0.02435336448252201,
-0.07508919388055801,
-0.0886588916182518,
-0.2153574377298355,
-0.0631759986281395,
0.517114520072937,
-0.7830047607421875,
-0.34730345010757446,
-0.28578004240989685,
-0.7184932231903076,
0.4093894064426422,
0.8331685066223145,
-0.33270642161369324,
-0.038917701691389084,
0.19552496075630188,
0.36574888229370117,
-0.30161911249160767,
0.2946440875530243,
0.6572797298431396,
0.8512691259384155,
-0.005125857423990965,
0.9338616132736206,
-0.011778103187680244,
-0.30507776141166687,
-0.5359081029891968,
-0.3038330376148224,
0.32201746106147766,
-0.5737500786781311,
0.49402639269828796,
0.6126055121421814,
0.006550743244588375,
-0.23004566133022308,
0.17033806443214417,
-0.49255988001823425,
-0.17895913124084473,
0.13123835623264313,
-0.14847604930400848,
-0.4082145094871521,
0.05047259107232094,
0.40821972489356995,
-0.6962035894393921,
-0.10438275337219238,
-0.04934954643249512,
-0.29190686345100403,
0.3427736759185791,
0.10230172425508499,
-0.6759382486343384,
0.34758493304252625,
0.6349889039993286,
-0.19681058824062347,
-0.24810035526752472,
0.30161339044570923,
0.0016595030901953578,
-0.2569805383682251,
-0.5051546096801758,
-0.05355309322476387,
-0.026601595804095268,
-0.14451362192630768,
0.19765914976596832,
0.2586691975593567,
-0.3293873965740204,
0.2800110876560211,
-0.5517376065254211,
0.12635429203510284,
-0.06187095865607262,
0.36624565720558167,
0.3630239963531494,
0.1602167934179306,
0.585250735282898,
-0.3490099310874939,
-0.048301856964826584,
-0.23516309261322021,
0.21832707524299622,
-0.2525259852409363,
0.09346688538789749,
-0.026315821334719658,
0.20729981362819672,
0.20816683769226074,
0.06599821150302887,
0.5764028429985046,
-0.6726319193840027,
0.22708116471767426,
0.4857349991798401,
-0.6671018004417419,
0.28907153010368347,
-0.5286855101585388,
0.4864223897457123,
-0.28794607520103455,
-0.11237653344869614,
-0.30817312002182007,
0.06741593033075333,
-0.5944969654083252,
-0.22821961343288422,
-0.47773709893226624,
-0.48550498485565186,
-0.025274401530623436,
0.0965879037976265,
0.16527238488197327,
-0.24141262471675873,
0.09170502424240112,
-0.1796429455280304,
-0.11506352573633194,
-0.058303844183683395,
0.3240801692008972,
0.7334516048431396,
0.17387880384922028,
-0.26673081517219543,
-0.19432522356510162,
0.23100872337818146,
-0.5464513301849365,
-0.25200921297073364,
0.07252094894647598,
0.3426652252674103,
0.5813212990760803,
-0.3658992052078247,
0.38186976313591003,
0.20777489244937897,
0.07192748785018921,
0.6422176957130432,
-0.30368971824645996,
-0.6278952360153198,
-0.38178569078445435,
0.17888708412647247,
-0.12768206000328064,
0.5127730965614319,
0.35823854804039,
0.5731052160263062,
-0.16634395718574524,
-0.27582576870918274,
0.6817306876182556,
-0.29218819737434387,
-0.654182493686676,
-0.46716830134391785,
0.1811157912015915,
0.3453480303287506,
-0.016496770083904266,
-0.03701680153608322,
0.3411882519721985,
-0.1607060432434082,
0.05917423591017723,
0.036726873368024826,
0.6882181763648987,
-0.010608606971800327,
-0.08212478458881378,
0.07043328881263733,
-0.14032359421253204,
0.7697188854217529,
-0.19798587262630463,
-0.8164629936218262,
0.25992682576179504,
0.43032675981521606,
0.20364180207252502,
-0.6863278150558472,
0.15201281011104584,
0.21299362182617188,
-0.8232590556144714,
-0.5818783640861511,
-0.7892853617668152,
0.34880128502845764,
0.06772711127996445,
0.5185538530349731,
0.8185004591941833,
0.7301778793334961,
-0.26209887862205505,
0.38388127088546753,
-0.25388002395629883,
0.3688172996044159,
0.5229052305221558,
-0.5336896777153015,
-0.36326512694358826,
0.17342598736286163,
0.26550132036209106,
-0.3318202793598175,
0.30525490641593933,
0.20964224636554718,
0.5831552147865295,
0.5477233529090881,
-0.31328773498535156,
-0.527586817741394,
0.18372252583503723,
0.3961876332759857,
0.31630900502204895,
-0.013590378686785698,
-0.4197933077812195,
-0.11604811251163483,
0.3184971809387207,
0.26476404070854187,
-0.3108121156692505,
-0.7938928604125977,
0.8091866970062256,
0.2996578514575958,
-0.1402311772108078,
0.020047657191753387,
0.3718293607234955,
0.44858255982398987,
-0.061758022755384445,
0.37395817041397095,
-0.07856935262680054,
0.38349449634552,
0.2430383563041687,
-0.13683617115020752,
-0.7711004018783569,
-0.10111548751592636,
0.2558334171772003,
-0.3175877034664154,
0.021159563213586807,
-0.4312690496444702,
-0.022391540929675102,
-0.18269655108451843,
0.3973654806613922,
-0.11396408081054688,
-0.3681927025318146,
-0.10512766242027283,
-0.9214392304420471,
0.13398130238056183,
-0.06182380020618439,
0.15356209874153137,
0.32825949788093567,
0.25667044520378113,
-0.3670007288455963,
-0.060953594744205475,
-0.6095771789550781,
0.0581207200884819,
0.9169654250144958,
-1.1781059503555298,
0.47228938341140747,
0.0007778236758895218,
-0.18847957253456116,
0.266235888004303,
-0.35177120566368103,
0.32083067297935486,
-0.08498340845108032,
-0.03839213773608208,
0.384613037109375,
-0.2546829581260681,
-0.2808949649333954,
-0.06589954346418381,
0.1113363578915596,
0.16242259740829468,
-0.047141727060079575,
0.27406516671180725,
-0.2155679613351822,
0.9912640452384949,
0.023071611300110817,
-0.18965975940227509,
-0.35989049077033997,
0.40131300687789917,
0.33617404103279114,
-0.49591174721717834,
-0.4987560510635376,
0.4941485524177551,
0.320821613073349,
0.048521894961595535,
-0.10158120095729828,
0.46677014231681824,
0.0625363141298294,
0.13424134254455566,
-0.2152961641550064,
-0.19522665441036224,
0.2503223121166229,
0.10141702741384506,
0.1384352147579193,
0.44006800651550293,
-0.6080821752548218,
0.2339998036623001,
0.2524629235267639,
-0.05904163420200348,
0.2672491669654846,
0.05595049262046814,
-0.008189606480300426,
0.5209907293319702,
0.7680271863937378,
-0.7164829969406128,
0.3375626802444458,
-0.0014104214496910572,
-0.5143270492553711,
-0.08134079724550247,
0.729178249835968,
-0.2074018120765686,
-0.3385869264602661,
-0.01196527760475874,
-0.15188468992710114,
0.5475671887397766,
-0.16557349264621735,
-0.24295420944690704,
0.26210933923721313,
-0.19557379186153412,
0.3584163784980774,
-0.060478903353214264,
0.296036958694458,
-0.0751461312174797,
0.11370962858200073,
0.615752100944519,
-0.550748884677887,
0.12870174646377563,
-0.0801655575633049,
-0.01912391558289528,
0.0040814680978655815,
0.3543778955936432,
-0.21088343858718872,
0.25030621886253357,
-0.13465999066829681,
-0.4387328028678894,
-0.3339090943336487,
-0.42470619082450867,
-0.8793124556541443,
-0.3761926293373108,
0.2180154025554657,
-0.2361222356557846,
0.1332368105649948,
-0.44636574387550354,
0.3157331943511963,
-1.1432478427886963,
0.007410889957100153,
-0.32265791296958923,
-0.09417049586772919,
-0.19180011749267578,
-0.09216778725385666,
0.895458996295929,
0.6291905045509338,
0.8297494649887085,
-0.2924236059188843,
0.07978557795286179,
-0.013507605530321598,
0.29885971546173096,
-0.2566795349121094,
0.2894495725631714,
0.37113699316978455,
-0.12302451580762863,
-0.38550856709480286,
0.11385270953178406,
1.4177470207214355,
0.3305357098579407,
-0.009975469671189785,
0.2115643322467804,
0.14709660410881042,
0.29623445868492126,
0.24982275068759918,
-0.8729797601699829,
0.40575769543647766,
0.1097133681178093,
-0.09073727577924728,
-0.34822988510131836,
0.4131010174751282,
0.5067504644393921,
-0.2890433967113495,
-0.14648661017417908,
0.38425031304359436,
0.6151232719421387,
-0.7968100309371948,
0.16611140966415405,
-0.015982644632458687,
-0.2774970829486847,
-0.43235450983047485,
0.6336513757705688,
-0.22770968079566956,
0.38241177797317505,
-0.40546029806137085,
0.523923933506012,
0.3412292003631592,
-0.3697910010814667,
0.18718402087688446,
-0.05562576279044151,
-0.10847275704145432,
0.2642776370048523,
-0.07057647407054901,
0.16188134253025055,
0.09448419511318207,
0.015435002744197845,
-0.717346727848053,
0.16172483563423157,
0.1913248896598816,
-0.5776790976524353,
-0.003057010704651475,
0.11387920379638672,
0.0626218244433403,
-0.011345642618834972,
-0.16346406936645508,
-0.3211844861507416,
-0.26523974537849426,
0.11528317630290985
] |
Are pathogens in outdoor air a health issue at present or will they become a problem in the future? A working group called AirPath - Outdoor Environments and Human Pathogens in Air was set up in 2007 at University College London, UK with the aim of opening new discussion and creating a research network to investigate the science and impacts of outdoor pathogens. Our objective in this paper is to review and discuss the following areas: What is the source of human pathogens in outdoor air? What current, developing and future techniques do we need? Can we identify at-risk groups in relation to their activities and environments? How do we prepare for the anticipated challenges of environmental change and new and emerging diseases? And how can we control for and prevent pathogens in outdoor environments? We think that this work can benefit the wider research community and policy makers by providing a concise overview of various research aspects and considerations which may be important to their work. | [
-0.002458810107782483,
0.02492498606443405,
-0.016141140833497047,
0.028817709535360336,
0.001105905743315816,
-0.022087611258029938,
0.00887872464954853,
0.015314256772398949,
-0.019633477553725243,
-0.03442288190126419,
0.015315105207264423,
0.03564738854765892,
0.007495054509490728,
0.021122554317116737,
0.011049965396523476,
0.02788897044956684,
-0.010130258277058601,
0.004908756352961063,
0.01139564998447895,
-0.01213265024125576,
-0.026096971705555916,
0.00019001471810042858,
0.009459733963012695,
-0.005352134816348553,
-0.0084452573210001,
0.013588923960924149,
0.006423567421734333,
-0.022001273930072784,
-0.040696002542972565,
0.02764766290783882,
0.045102402567863464,
-0.0037534907460212708,
0.035755060613155365,
0.0011881468817591667,
0.009834865108132362,
0.024214453995227814,
-0.003738999832421541,
0.0070626698434352875,
0.0164780430495739,
-0.002513726707547903,
0.020892277359962463,
-0.0014155235840007663,
-0.00004983763210475445,
-0.01197906956076622,
-0.010758543387055397,
0.004776081070303917,
-0.008193660527467728,
0.012798959389328957,
-0.001254718517884612,
0.012665577232837677,
0.0012311304453760386,
0.041466280817985535,
-0.006174357142299414,
0.01847243309020996,
-0.007266020402312279,
-0.02150360867381096,
0.02418089658021927,
0.013028018176555634,
0.007095187436789274,
-0.02914152666926384,
0.01709607057273388,
-0.00032747117802500725,
0.029312770813703537,
0.004820750094950199,
-0.016766592860221863,
-0.06609661877155304,
0.03173695504665375,
0.010416163131594658,
-0.00247826031409204,
0.016410233452916145,
0.004140976816415787,
0.01821114867925644,
-0.009922921657562256,
-0.005716037005186081,
0.00890270248055458,
-0.006405924912542105,
-0.004111557267606258,
0.0063156429678201675,
-0.00796885322779417,
0.010214433073997498,
-0.014750810340046883,
-0.010710740461945534,
-0.041565340012311935,
0.035076722502708435,
-0.0011998615227639675,
0.029530134052038193,
-0.004238401539623737,
-0.021708421409130096,
-0.011723957024514675,
0.03180656582117081,
0.018965354189276695,
-0.026380103081464767,
-0.017786704003810883,
-0.029070086777210236,
-0.035900458693504333,
0.007095059845596552,
-0.03757651150226593,
0.01733819954097271,
0.026131976395845413,
0.005554465111345053,
0.014522490091621876,
-0.0001453729346394539,
0.034676969051361084,
0.03302407264709473,
0.009011819958686829,
0.013200592249631882,
-0.012694846838712692,
0.02748063951730728,
-0.01017061434686184,
0.009641991928219795,
0.0031011002138257027,
0.012465458363294601,
0.0017339210025966167,
0.03085874579846859,
0.00013351329835131764,
0.036756791174411774,
0.011071816086769104,
0.004417696036398411,
0.0050749219954013824,
-0.022493330761790276,
-0.010472881607711315,
-0.0006071014795452356,
-0.006591171491891146,
0.019059807062149048,
0.00370577909052372,
0.028123632073402405,
-0.018856283277273178,
-0.014346286654472351,
0.005310344975441694,
0.00429794006049633,
-0.008841527625918388,
-0.023405546322464943,
-0.024617012590169907,
-0.00676913745701313,
0.00034184567630290985,
-0.007609279360622168,
-0.008893560618162155,
0.01661410741508007,
-0.013963032513856888,
0.00030279019847512245,
-0.010425576940178871,
0.00969710573554039,
0.002435249276459217,
0.006194860674440861,
0.0398586168885231,
-0.0018873077351599932,
-0.0151266660541296,
0.013695642352104187,
0.016645392403006554,
-0.003609277307987213,
0.026540737599134445,
-0.017048429697752,
-0.026394829154014587,
-0.00056673982180655,
0.009503504261374474,
-0.0016896510496735573,
0.013039018958806992,
0.003498121164739132,
-0.008435757830739021,
-0.002035378711298108,
-0.014736778102815151,
0.00032739387825131416,
0.0036326353438198566,
0.009841280989348888,
0.006505296099931002,
-0.013742435723543167,
-0.009322789497673512,
0.016643501818180084,
-0.005944415926933289,
0.0007946552941575646,
-0.012255595065653324,
-0.01143654529005289,
-0.014216403476893902,
0.012165271677076817,
-0.019344689324498177,
-0.0005249842070043087,
0.025601383298635483,
0.007302748039364815,
-0.010941509157419205,
0.0664241835474968,
-0.0117068812251091,
0.04426014795899391,
-0.024369047954678535,
0.015434043481945992,
0.015270832926034927,
-0.0128581328317523,
0.012966686859726906,
-0.017314836382865906,
-0.003694141749292612,
0.023381009697914124,
-0.01091611199080944,
0.007437817752361298,
0.0218809824436903,
-0.015667423605918884,
0.0028219420928508043,
0.0032137802336364985,
0.011089175939559937,
-0.0021631980780512094,
0.0019565082620829344,
-0.022509675472974777,
0.014673699624836445,
0.01337251253426075,
0.04478245973587036,
-0.016574958339333534,
-0.004288198426365852,
-0.00545684527605772,
0.006950716953724623,
-0.005589197389781475,
-0.01432215329259634,
0.004415726754814386,
0.007056840695440769,
0.011600852943956852,
-0.005411595106124878,
-0.003158323001116514,
0.009711500257253647,
0.012193242087960243,
0.001653731451369822,
-0.017198748886585236,
-0.006883817724883556,
-0.023526810109615326,
-0.011780336499214172,
0.010046178475022316,
-0.001345246797427535,
-0.006307884119451046,
-0.0004618684761226177,
0.0007555871270596981,
0.01469370536506176,
0.016060054302215576,
0.04273935779929161,
0.00790378637611866,
0.000460831040982157,
-0.021832117810845375,
-0.007307824678719044,
-0.029103253036737442,
0.018306676298379898,
0.01992497220635414,
0.009004304185509682,
-0.013101632706820965,
0.002122849225997925,
-0.006716914474964142,
0.02203083038330078,
0.0003895629197359085,
0.010540364310145378,
0.023550836369395256,
-0.008863694965839386,
0.011521058157086372,
0.021254032850265503,
-0.004479798022657633,
-0.014130176976323128,
0.01714717410504818,
0.004405486863106489,
-0.033293962478637695,
0.006793824955821037,
-0.01773577556014061,
0.01340972539037466,
0.005590599495917559,
-0.0297396257519722,
-0.004109808709472418,
0.028122659772634506,
-0.02761749178171158,
0.010649081319570541,
0.005857974756509066,
0.025052417069673538,
-0.04642847925424576,
0.0052077313885092735,
0.02615015208721161,
0.019632557407021523,
0.014763224869966507,
0.021789588034152985,
-0.02540026232600212,
0.006514642853289843,
-0.014659995213150978,
-0.003536282805725932,
-0.08132581412792206,
-0.00790051743388176,
-0.0068154786713421345,
-0.04416152089834213,
0.02150331437587738,
0.000685177044942975,
-0.00580901512876153,
0.029158834367990494,
-0.01715180277824402,
0.013352954760193825,
-0.009642785415053368,
-0.004710560664534569,
0.000010705552995204926,
-0.025216201320290565,
-0.0034394538961350918,
-0.012755334377288818,
0.00851911585777998,
-0.01074394304305315,
-0.025453194975852966,
-0.014348218217492104,
-0.004086813889443874,
-0.001785764005035162,
-0.009220287203788757,
-0.02279837056994438,
-0.0022204965353012085,
-0.03012668900191784,
0.012762743979692459,
0.0009121906477957964,
0.001391667639836669,
0.016771744936704636,
0.036962851881980896,
-0.02863433212041855,
-0.026292890310287476,
-0.038862358778715134,
-0.01840176060795784,
0.007250801660120487,
-0.024986008182168007,
-0.008696495555341244,
-0.009377344511449337,
0.009090099483728409,
0.006161221768707037,
0.020642360672354698,
0.014525100588798523,
-0.0017569680931046605,
0.006454230286180973,
0.009964500553905964,
-0.021140206605196,
-0.008784810081124306,
0.01295741181820631,
0.0050736116245388985,
0.014924884773790836,
-0.0265875905752182,
0.029914168640971184,
0.00873594731092453,
-0.010505994781851768,
-0.01458314061164856,
-0.010134627111256123,
0.01800263300538063,
-0.006486257538199425,
0.004247421398758888,
-0.010114170610904694,
-0.010179447941482067,
0.025283165276050568,
0.013727971352636814,
-0.030710842460393906,
0.005992800462990999,
0.010268982499837875,
0.007099013775587082,
0.005676437169313431,
0.018941111862659454,
-0.00963324774056673,
-0.03280533105134964,
0.02199568785727024,
-0.0005036144284531474,
-0.005969801917672157,
-0.0027374259661883116,
-0.025618435814976692,
0.002676574978977442,
0.004497981630265713,
0.0331471785902977,
0.014179893769323826,
0.010576223954558372,
0.002444041892886162,
-0.01085389219224453,
-0.006205857265740633,
-0.0017948292661458254,
0.01688993163406849,
0.0032409965060651302,
0.0005110874772071838,
-0.019729819148778915,
0.02378949709236622,
0.01285415980964899,
-0.011162109673023224,
0.0005306331440806389,
0.024055276066064835,
-0.0009165997616946697,
-0.004886548034846783,
0.013436483219265938,
-0.002990303561091423,
0.01020706444978714,
-0.011664256453514099,
-0.0061998614110052586,
-0.008189374580979347,
-0.02240503579378128,
0.0068367887288331985,
0.01321948878467083,
0.0016412679105997086,
-0.005294275935739279,
-0.03777942806482315,
-0.011470982804894447,
-0.014809472486376762,
-0.012368416413664818,
-0.006668265908956528,
0.004851471167057753,
0.017136111855506897,
-0.01667538657784462,
-0.0093328095972538,
0.014972002245485783,
0.07137234508991241,
0.014130551367998123,
0.020008884370326996,
0.001939411275088787,
0.00843867938965559,
-0.03434891998767853,
0.031660571694374084,
-0.0035198621917515993,
0.04241248220205307,
-0.031183235347270966,
0.0164908729493618,
-0.019736744463443756,
-0.018236489966511726,
-0.012819468975067139,
0.009137543849647045,
-0.0034435195848345757,
0.02454661764204502,
0.012298437766730785,
-0.006389222573488951,
-0.014908326789736748,
0.01253495179116726,
-0.0016209238674491644,
0.01723397523164749,
0.037039339542388916,
0.007109284400939941,
-0.011523647233843803,
-0.02036304585635662,
-0.012230206280946732,
0.021616976708173752,
-0.001390717108733952,
0.031256053596735,
0.012694928795099258,
-0.006710788235068321,
-0.01970711722970009,
-0.010359232313930988,
0.013323991559445858,
0.027841249480843544,
-0.01908547431230545,
-0.011299396865069866,
-0.0009252680465579033,
-0.04528370499610901,
-0.010421501472592354,
0.04018952697515488,
0.006480824202299118,
-0.025556985288858414,
0.031883955001831055,
-0.0162237249314785,
-0.00525310542434454,
-0.005831747315824032,
0.030033249408006668,
-0.008969904854893684,
0.0335942842066288,
-0.001972626196220517,
0.012982390820980072,
0.009535737335681915,
-0.017426472157239914,
0.0020712297409772873,
0.0038328280206769705,
0.011488325893878937,
-0.017060238867998123,
-0.04093912988901138,
0.0013556531630456448,
0.024939585477113724,
-0.03095974214375019,
-0.0006127746310085058,
0.010500388219952583,
-0.0019890745170414448,
-0.010255633853375912,
-0.004637032747268677,
0.010119115933775902,
-0.015061278827488422,
-0.005467603914439678,
-0.008437369018793106,
-0.004504883661866188,
-0.025683913379907608,
-0.04196437448263168,
0.022638767957687378,
0.004322403110563755,
-0.005625789985060692,
0.034338902682065964,
0.011687549762427807,
0.015116719529032707,
-0.0029780021868646145,
0.022646352648735046,
0.02790156751871109,
0.026576168835163116,
-0.03140414506196976,
-0.07466913759708405,
0.015406956896185875,
-0.027283988893032074,
-0.00807859841734171,
0.002085302956402302,
-0.021475497633218765,
-0.02150675654411316,
0.00803512055426836,
-0.043036140501499176,
-0.013099787756800652,
-0.04113250970840454,
0.005797788500785828,
0.009862732142210007,
0.034664690494537354,
0.014180686324834824,
0.039730556309223175,
0.0061301677487790585,
-0.010546466335654259,
0.0011851047165691853,
0.001688810414634645,
-0.00894356518983841,
-0.008491473272442818,
-0.00278243375942111,
-0.0015495960833504796,
0.026405032724142075,
-0.08015190064907074,
-0.02271995320916176,
-0.001010038424283266,
0.00031085009686648846,
-0.00382435554638505,
0.0041178148239851,
0.032765116542577744,
-0.016813814640045166,
0.023228511214256287,
-0.019414320588111877,
-0.005443953908979893,
-0.012269023805856705,
-0.0006495327688753605,
-0.010941713117063046,
-0.015220935456454754,
-0.004548290744423866,
0.006737184710800648,
0.025433901697397232,
0.006741517223417759,
-0.0016577662900090218,
0.00507684051990509,
0.015595300123095512,
-0.007536879740655422,
-0.011283498257398605,
-0.009072303771972656,
-0.015333134680986404,
-0.0017502179834991693,
0.011314725503325462,
0.017438992857933044,
-0.02518613450229168,
-0.030681002885103226,
-0.004541154485195875,
-0.004191041458398104,
-0.040701061487197876,
0.006004138384014368,
-0.01276763342320919,
0.031032200902700424,
0.0011144280433654785,
-0.023062091320753098,
-0.018075663596391678,
0.002424523700028658,
-0.006413170136511326,
0.048993177711963654,
0.006497770082205534,
0.023744015023112297,
-0.06521748006343842,
0.013541340827941895,
-0.002345021115615964,
0.027690455317497253,
-0.010970935225486755,
0.0005076716188341379,
0.03650893270969391,
0.016762208193540573,
0.005454860627651215,
-0.003417817410081625,
-0.021490007638931274,
-0.008520698174834251,
-0.009173287078738213,
-0.008957242593169212,
0.02897043526172638,
0.011378282681107521,
0.004668897017836571,
-0.015030468814074993,
0.0712994784116745,
-0.004704623948782682,
0.00757749006152153,
0.019343562424182892,
-0.009807645343244076,
-0.0018002167344093323,
-0.004535944201052189,
-0.013161856681108475,
0.01331848930567503,
-0.024599513038992882,
0.007470585405826569,
-0.0010256029199808836,
-0.02117609977722168,
0.0009773430647328496,
0.012620098888874054,
-0.020773345604538918,
-0.002919470425695181,
0.007098944392055273,
-0.03635124862194061,
-0.029797475785017014,
-0.012823302298784256,
0.003632316831499338,
-0.032925523817539215,
-0.015602726489305496,
0.01259575504809618,
0.003587803104892373,
-0.005471787881106138,
-0.010975375771522522,
0.013629294000566006,
0.012270278297364712,
-0.006378671154379845,
-0.010869690217077732,
0.005073814652860165,
0.0066977874375879765,
0.008053489960730076,
0.025532450526952744,
0.01454460620880127,
-0.0030784537084400654,
0.014662286266684532,
0.038471609354019165,
0.018312569707632065,
0.0082569420337677,
0.01333375833928585,
-0.031424157321453094,
-0.013099707663059235,
-0.04516000300645828,
-0.005971782840788364,
0.033487096428871155,
0.027854759246110916,
0.01082371175289154,
0.028660856187343597,
0.009830527007579803,
0.01623808778822422,
-0.003732546465471387,
0.006489328574389219,
0.021021898835897446,
0.011004269123077393,
0.018866755068302155,
0.008127011358737946,
-0.019844897091388702,
0.018533913418650627,
-0.016540072858333588,
-0.016869615763425827,
-0.017626404762268066,
0.015285934321582317,
-0.00047880783677101135,
-0.007900400087237358,
-0.028342876583337784,
-0.015800833702087402,
0.009222909808158875,
-0.002698818687349558,
0.025727860629558563,
-0.0003610500134527683,
-0.02701185643672943,
0.014392661862075329,
-0.014941006898880005,
0.015489629469811916,
0.017536522820591927,
0.0026244816835969687,
0.0022356093395501375,
-0.007623538374900818,
-0.04619742929935455,
0.021776992827653885,
-0.004569936543703079,
-0.0334717221558094,
-0.010517953895032406,
0.009287634864449501,
-0.0033431509509682655,
-0.007627599872648716,
0.013451829552650452,
0.03343117982149124,
-0.002640289254486561,
0.0034248505253344774,
0.000659824931062758,
0.006615271791815758,
0.03792303800582886,
-0.016152188181877136,
0.00648972624912858,
-0.025415748357772827,
0.018349315971136093,
-0.024430327117443085,
-0.026828426867723465,
-0.0026432787999510765,
-0.004695088602602482,
-0.01061016134917736,
-0.00625631446018815,
0.022527191787958145,
0.013382449746131897,
0.010211504995822906,
0.014035566709935665,
-0.0376846008002758,
-0.00965539738535881,
-0.023443065583705902,
0.018673378974199295,
0.01584523543715477,
0.025552507489919662,
-0.005710716359317303,
-0.03216864541172981,
-0.003355208318680525,
-0.013354765251278877,
-0.020260117948055267,
-0.007822087034583092,
0.013974112458527088,
0.022540487349033356,
-0.016122248023748398,
-0.020355943590402603,
-0.00138066615909338,
-0.012850925326347351,
0.008896568790078163,
-0.010160554200410843,
0.019471952691674232,
-0.0025208345614373684,
-0.0037675458006560802,
-0.011872122064232826,
0.0035538000520318747,
-0.016367951408028603,
-0.030987311154603958,
-0.006036411039531231,
-0.014910084195435047,
-0.023028850555419922,
-0.0006112048868089914,
-0.005977268796414137,
-0.008009672164916992,
-0.019978594034910202,
0.013991613872349262,
0.015806786715984344,
-0.026597848162055016,
0.024491947144269943,
0.009582269936800003,
0.02860255539417267,
0.011737541295588017,
0.0035020809154957533,
-0.004762556869536638,
0.004187688697129488,
-0.0011231577955186367,
0.004353050142526627,
0.003057649824768305,
0.00882374495267868,
-0.004909784998744726,
0.015849264338612556,
0.004069841466844082,
-0.00043261703103780746,
-0.010263202711939812,
0.003260499332100153,
-0.01285045687109232,
-0.0043436940759420395,
-0.018175248056650162,
0.008185682818293571,
0.0071298363618552685,
0.04096241295337677,
0.001736372709274292,
0.0052735465578734875,
-0.008511093445122242,
0.02598753571510315,
-0.018370239064097404,
-0.013082915917038918,
-0.01909116841852665,
0.02338515780866146,
-0.01678277738392353,
0.022392122074961662,
0.023968588560819626,
-0.00942917913198471,
0.010476280935108662,
-0.013758933171629906,
-0.016523147001862526,
0.007028732914477587,
-0.016328707337379456,
-0.0034684748388826847,
0.017197227105498314,
-0.010844644159078598,
-0.010466450825333595,
-0.0053115165792405605,
-0.01583954319357872,
-0.017749914899468422,
0.01610414683818817,
-0.0062850844115018845,
-0.006168338470160961,
0.0015122173354029655,
-0.008697055280208588,
0.020816214382648468,
0.017203953117132187,
0.0021473229862749577
] | [
0.7372661232948303,
0.3800759017467499,
-0.013384057208895683,
-0.13852839171886444,
-0.3282400965690613,
-0.04554283991456032,
0.2811664342880249,
-0.34777799248695374,
-0.03462444618344307,
-0.4820238947868347,
-0.1569484919309616,
0.26169246435165405,
-0.26392629742622375,
-0.05577489361166954,
0.11368659883737564,
0.3973684012889862,
0.06872288137674332,
0.22614312171936035,
-0.08629214018583298,
0.08591006696224213,
-0.08880284428596497,
-0.6891584396362305,
0.5266373753547668,
-0.07075881958007812,
0.3272774815559387,
-0.5799079537391663,
0.6050282716751099,
0.7736145853996277,
0.11132877320051193,
-0.027964087203145027,
-0.1086130142211914,
0.2915797829627991,
-0.22011703252792358,
-0.6743069887161255,
-0.0356161929666996,
0.10048964619636536,
0.1000499576330185,
-0.006121030077338219,
-0.08802817761898041,
-0.18374422192573547,
-0.14270471036434174,
0.5702352523803711,
-0.8028838038444519,
0.3365943729877472,
0.11126091331243515,
-0.16436873376369476,
-1.2945611476898193,
-0.2793749272823334,
-0.17300301790237427,
0.18387530744075775,
0.15400120615959167,
0.45537877082824707,
0.3608488142490387,
0.3425293266773224,
0.15813753008842468,
0.34102997183799744,
-0.48666080832481384,
-0.44381609559059143,
-0.27382445335388184,
-0.3523544371128082,
0.3322511911392212,
0.26618945598602295,
-0.5271999835968018,
0.07487863302230835,
-0.19247427582740784,
0.3539597690105438,
0.015617523342370987,
-0.07436244934797287,
0.20369809865951538,
0.04270336031913757,
-0.10179577022790909,
-0.45896002650260925,
-0.503437340259552,
0.498122900724411,
-0.22862949967384338,
-0.23317380249500275,
0.6801973581314087,
-0.2815832495689392,
0.05080362781882286,
0.029521837830543518,
0.01604081690311432,
-0.038861244916915894,
0.08011815696954727,
0.0867651179432869,
0.629112184047699,
0.12067592144012451,
-0.3885962665081024,
0.5730311274528503,
-0.333920419216156,
0.051190201193094254,
0.4671853482723236,
-0.48779410123825073,
0.6566186547279358,
0.1284802258014679,
0.80588299036026,
0.21617533266544342,
0.45600426197052,
0.07288775593042374,
-0.20865082740783691,
-0.02630167081952095,
-0.3496597409248352,
0.3339127004146576,
-0.017872733995318413,
0.12256866693496704,
-0.30702295899391174,
-0.5880835056304932,
-0.2730969488620758,
-0.5663805603981018,
0.11038707196712494,
0.29190266132354736,
-0.3392425775527954,
0.11256842315196991,
0.16142800450325012,
-0.2738155722618103,
0.08264358341693878,
0.6217087507247925,
0.5742298364639282,
-0.5328676104545593,
-0.1340208649635315,
0.561881959438324,
-0.042818520218133926,
0.9629186987876892,
0.04363670200109482,
0.31430673599243164,
-0.586701512336731,
-0.196646586060524,
0.6323797702789307,
0.052915655076503754,
-0.4953412711620331,
0.2760995924472809,
-0.06757884472608566,
0.5341920852661133,
-0.3771212100982666,
-0.328271746635437,
0.05289936438202858,
-0.05399791896343231,
0.2850070595741272,
0.20615693926811218,
0.3309563100337982,
0.3118845224380493,
-0.12418323755264282,
-0.8551723957061768,
-0.3158184885978699,
-0.20366831123828888,
0.06057882681488991,
-0.4074632525444031,
-0.2368030995130539,
-0.2406356781721115,
-0.18448245525360107,
-0.05127866938710213,
-0.06763505935668945,
0.05566027760505676,
-0.6802307963371277,
0.1264614760875702,
-0.45194002985954285,
0.6298421621322632,
0.12623848021030426,
0.2122776210308075,
-0.0249759741127491,
0.09920667111873627,
0.37906524538993835,
-0.34421929717063904,
-0.630327582359314,
0.004601748194545507,
0.3250451683998108,
-0.11555267870426178,
-0.5319697856903076,
0.2579073905944824,
0.6490753293037415,
-0.11181175708770752,
-0.4806724190711975,
-0.3273256719112396,
0.2598971426486969,
-1.152696967124939,
-0.10838692635297775,
-0.03074333630502224,
0.6314458250999451,
0.046348556876182556,
0.12367727607488632,
0.5611419677734375,
-0.5495998859405518,
-0.5779902935028076,
-0.09185446798801422,
-0.14734847843647003,
0.5765866041183472,
-0.0741378590464592,
0.36907145380973816,
0.21067312359809875,
0.05186052992939949,
0.47939005494117737,
-0.5519922971725464,
-0.607899010181427,
0.6972358226776123,
-0.723911464214325,
1.128843903541565,
-0.0335039347410202,
0.07091410458087921,
1.2475335597991943,
-0.35879114270210266,
0.2881833016872406,
-0.04524550586938858,
0.26282835006713867,
0.20006288588047028,
-0.4228382706642151,
-0.7364435195922852,
-0.25195538997650146,
-0.15304382145404816,
-0.2901155650615692,
-0.2436605542898178,
0.17150264978408813,
0.4759308099746704,
-0.4889303147792816,
-0.11367849260568619,
-0.3452526926994324,
0.06733616441488266,
0.22822149097919464,
-0.484214186668396,
0.4665800929069519,
-0.2436751276254654,
-0.7188272476196289,
0.48464253544807434,
-0.21940337121486664,
0.37709134817123413,
0.3177907168865204,
-0.13347893953323364,
0.5289621353149414,
0.2308797836303711,
0.18579676747322083,
0.6434004306793213,
-1.0135630369186401,
0.5515612959861755,
0.18310998380184174,
0.18004345893859863,
-0.9434787034988403,
-0.20855368673801422,
0.3988321125507355,
-0.04610792547464371,
-0.5008314847946167,
0.18701976537704468,
0.052255481481552124,
0.13425014913082123,
0.4146249294281006,
-0.7205034494400024,
0.6738035678863525,
-0.1434994637966156,
-0.2047596424818039,
0.28849005699157715,
0.3418998420238495,
-0.4655095636844635,
0.4468439519405365,
0.44147729873657227,
0.37202388048171997,
0.10980300605297089,
-0.23926399648189545,
-0.23625563085079193,
0.16416053473949432,
-0.42692166566848755,
-0.5337926745414734,
0.7543163299560547,
-0.19640223681926727,
-0.03392960876226425,
0.3843269646167755,
0.1657949686050415,
0.35449549555778503,
0.17955727875232697,
-0.6368356347084045,
-0.3898942172527313,
-1.002212405204773,
0.30076363682746887,
0.2465706169605255,
1.0659234523773193,
0.20178020000457764,
-0.24890246987342834,
0.26699098944664,
-0.012695818208158016,
-0.2800852656364441,
0.3653017580509186,
0.7662787437438965,
0.06285125762224197,
-0.18816296756267548,
-0.2110210657119751,
0.8038932681083679,
0.7283246517181396,
-0.12838102877140045,
-0.22550243139266968,
-0.1027313843369484,
0.40267693996429443,
-0.005940653849393129,
-0.6392039656639099,
0.5021877288818359,
0.1368405967950821,
0.03948786109685898,
-0.09914083778858185,
0.06750275194644928,
0.13234716653823853,
0.3523588478565216,
-0.2852013409137726,
0.1330953985452652,
0.34425923228263855,
-0.1924707442522049,
-0.1217021644115448,
0.2191590517759323,
-0.7851717472076416,
-0.08129191398620605,
-0.5659737586975098,
-0.4810639023780823,
-0.9531864523887634,
-0.3329579532146454,
-5.87882661819458,
-0.35970044136047363,
-0.00778968958184123,
0.2953941524028778,
-0.7093550562858582,
0.5884367823600769,
0.6982747912406921,
-0.49147334694862366,
-0.14961712062358856,
0.1467096209526062,
0.602822482585907,
-0.009656226262450218,
0.6288145780563354,
0.6068583130836487,
0.410479873418808,
0.26079824566841125,
0.35432299971580505,
-0.7839612364768982,
0.07567248493432999,
-0.004229804500937462,
0.28284648060798645,
-0.21853360533714294,
0.21705733239650726,
0.3118043839931488,
0.49968811869621277,
0.14246468245983124,
-0.9382163882255554,
0.4998099207878113,
0.46379390358924866,
0.031368233263492584,
0.8628039360046387,
-0.7058277726173401,
-0.22607527673244476,
0.0546267032623291,
0.1972183883190155,
0.30906617641448975,
0.06325311958789825,
0.2789497375488281,
-0.0010139294900000095,
-0.06673074513673782,
0.28928712010383606,
-0.06161854788661003,
-0.32656237483024597,
-0.1741069108247757,
-0.040717557072639465,
-0.029383620247244835,
-0.35907381772994995,
0.1928507536649704,
0.029739251360297203,
0.28621727228164673,
0.20476765930652618,
0.2664339244365692,
0.4769143760204315,
0.05027718469500542,
-0.04226331785321236,
-0.3959573805332184,
0.3098856210708618,
0.01855544000864029,
0.03188313916325569,
-0.0934886708855629,
-0.16407550871372223,
-0.4087476134300232,
0.4599461853504181,
-0.44197967648506165,
-0.1274328976869583,
0.4620268642902374,
-0.7161238193511963,
-0.5968057513237,
0.32228797674179077,
-0.15536537766456604,
-0.40849733352661133,
0.29553574323654175,
0.05571546405553818,
-0.7486206293106079,
-0.12683355808258057,
-0.1337835192680359,
0.47766178846359253,
-0.13730862736701965,
0.08349158614873886,
-0.5497527718544006,
-0.11694111675024033,
-0.32135429978370667,
-0.1533898115158081,
0.3073055148124695,
-0.0020873432513326406,
-0.7768357992172241,
0.06840386241674423,
-0.3882236182689667,
-0.5348407030105591,
0.10088544338941574,
0.5460234880447388,
-0.5092472434043884,
-0.1764303296804428,
0.6947021484375,
0.3165498673915863,
0.574325680732727,
-0.05352901294827461,
-0.15905167162418365,
0.5600100755691528,
0.035305388271808624,
0.48490482568740845,
-0.1775447577238083,
-0.28100118041038513,
-0.9887019395828247,
0.02740480750799179,
-0.09225841611623764,
-0.3532807528972626,
-0.11263051629066467,
0.7737109065055847,
-0.544189453125,
0.06805581599473953,
0.29640477895736694,
-0.29880887269973755,
-0.04801390692591667,
0.02529442124068737,
-0.24849730730056763,
-0.14707635343074799,
0.26716336607933044,
0.3108619451522827,
-0.3017873167991638,
-0.00657274853438139,
0.1317695677280426,
0.41898736357688904,
0.18577560782432556,
-0.17098736763000488,
-0.026512490585446358,
0.2710181772708893,
0.7234031558036804,
-0.7386559247970581,
0.00898266676813364,
0.3002743422985077,
0.5601028800010681,
-0.3448982536792755,
0.1170218363404274,
0.043797146528959274,
-0.09638155251741409,
-0.4796043336391449,
-0.3676888048648834,
0.13720931112766266,
0.13492663204669952,
-0.10578571259975433,
-0.2758963108062744,
0.18696074187755585,
0.019707389175891876,
0.42851486802101135,
0.16840504109859467,
-0.07536708563566208,
-0.42520228028297424,
-0.24413026869297028,
-0.14319613575935364,
0.04800659418106079,
0.10352885723114014,
0.015394894406199455,
0.04814590513706207,
0.0979345291852951,
-0.5091541409492493,
0.5053004622459412,
-0.04912567511200905,
-0.17761829495429993,
-0.5233228206634521,
0.6985197067260742,
-0.027006721124053,
-0.9103764295578003,
-0.10111767053604126,
-0.23582366108894348,
0.0864529013633728,
0.061603520065546036,
-0.27670425176620483,
-0.2678931951522827,
0.0213463231921196,
0.028486056253314018,
-0.6620084643363953,
-0.3296196460723877,
-0.06663323193788528,
-0.052373796701431274,
-0.2242254912853241,
-0.09759023040533066,
0.23227469623088837,
-0.27853769063949585,
-0.12609300017356873,
0.27524495124816895,
-0.4709499776363373,
-0.6158692836761475,
0.17293322086334229,
0.7570092082023621,
-0.26599061489105225,
0.04659495875239372,
-0.5249909162521362,
-0.17517025768756866,
-0.41793888807296753,
0.16766124963760376,
0.34117451310157776,
0.5677698254585266,
0.056887950748205185,
-0.22001318633556366,
-0.5728487372398376,
0.2562539577484131,
-0.15745104849338531,
-0.7060016989707947,
-0.5085800290107727,
0.11855552345514297,
0.35421112179756165,
-0.4448595345020294,
0.8426554799079895,
-0.10715699195861816,
-0.533824622631073,
-0.4533599019050598,
-0.03396899253129959,
-0.20206083357334137,
-0.033972326666116714,
-0.21262791752815247,
0.06767575442790985,
0.2540941834449768,
0.4858201742172241,
-0.6662060022354126,
0.20753218233585358,
-0.1274530589580536,
0.39714518189430237,
-0.2078205645084381,
0.2481282651424408,
-0.11904110014438629,
0.19811925292015076,
-0.49860724806785583,
0.11899071931838989,
-0.4864681363105774,
0.49467453360557556,
0.9200915694236755,
-0.46577998995780945,
-0.507685124874115,
0.0403980016708374,
-0.2276475578546524,
0.42646974325180054,
0.531173050403595,
-0.01698095165193081,
-0.23946090042591095,
-0.2833036780357361,
-0.09481625258922577,
-0.20075543224811554,
-0.548880398273468,
0.7199416756629944,
-0.07081664353609085,
0.37122642993927,
-0.3761354386806488,
-0.5634787082672119,
0.006319562904536724,
0.7203763127326965,
0.1389664262533188,
-0.6924623250961304,
-0.5658868551254272,
-0.4222431480884552,
0.10303978621959686,
-0.14525628089904785,
0.0563167966902256,
0.24337230622768402,
0.5763358473777771,
-0.28862443566322327,
-0.3059696555137634,
-0.07866626977920532,
-0.017489010468125343,
-0.35569000244140625,
0.2162080556154251,
-0.16805797815322876,
-0.6790717840194702,
0.37683337926864624,
0.33326810598373413,
-0.15114672482013702,
-0.145309180021286,
-0.595472514629364,
-0.07360366731882095,
-0.2964975833892822,
0.2799757719039917,
-0.03656493499875069,
0.6437618136405945,
0.8068148493766785,
0.571186363697052,
-0.22595010697841644,
-0.23889954388141632,
-0.29906976222991943,
-0.05915594473481178,
-0.1334330439567566,
-0.22472929954528809,
-0.4280957877635956,
0.03963329643011093,
-0.2894901633262634,
0.4047437012195587,
-0.48266711831092834,
0.6018228530883789,
0.11821241676807404,
-0.23167768120765686,
-0.4077378213405609,
-0.08403372019529343,
-0.18759578466415405,
-0.38502565026283264,
-0.04762763902544975,
0.03824193775653839,
0.19740740954875946,
0.21473102271556854,
0.004752092994749546,
0.41664019227027893,
-0.902647852897644,
-0.7943987250328064,
0.3700127601623535,
0.4517102837562561,
-0.36989250779151917,
0.2604342997074127,
0.2926705777645111,
0.367848664522171,
0.12684385478496552,
-0.11990664154291153,
-0.3594309091567993,
0.30348244309425354,
0.048814017325639725,
-0.2447468787431717,
0.9434277415275574,
-0.9401208758354187,
0.27455058693885803,
-0.10958398133516312,
-0.36460551619529724,
0.6251247525215149,
0.1904018521308899,
-0.051709894090890884,
0.2983900308609009,
0.37860602140426636,
0.09808605909347534,
-0.5621804594993591,
0.5265395045280457,
-0.0473061241209507,
0.45482808351516724,
-0.11729694157838821,
0.23323918879032135,
0.5341251492500305,
0.651103675365448,
-0.36489078402519226,
0.4820651710033417,
0.37736546993255615,
0.05349881574511528,
0.1794053316116333,
-0.697744607925415,
-0.5533415079116821,
0.02877555601298809,
0.6350757479667664,
0.32564881443977356,
0.2275904268026352,
-0.1367035061120987,
-0.2604266405105591,
0.3364783823490143,
0.1412821114063263,
-0.05353663116693497,
0.2385798543691635,
0.3456469774246216,
0.015837009996175766,
0.2952830195426941,
-0.07167435437440872,
0.153474822640419,
-0.4481622576713562,
0.32409846782684326,
0.7177985310554504,
-0.31917864084243774,
-0.5218613743782043,
0.5537734031677246,
-0.038948845118284225,
0.23530304431915283,
-0.30802109837532043,
0.19217026233673096,
-0.3286174237728119,
0.05879100784659386,
0.2502053678035736,
0.02545085921883583,
0.17599432170391083,
0.02978735789656639,
-0.22955100238323212,
0.11502742767333984,
-0.6038001775741577,
0.28609201312065125,
-0.07294315844774246,
-0.24819409847259521,
0.6141790151596069,
-0.13255544006824493,
0.2785353362560272,
0.4342803955078125,
0.38672465085983276,
0.5740716457366943,
-0.17576977610588074,
-0.8318158388137817,
0.414440780878067,
0.24177885055541992,
-0.4759593904018402,
0.5524331331253052,
0.3963448107242584,
-0.4092158377170563,
-0.12268860638141632,
-0.4623962640762329,
-0.08831173926591873,
0.1683751344680786,
-0.05197322741150856,
-0.439452588558197,
0.05465100705623627,
0.3805806636810303,
0.12402947247028351,
-0.43121957778930664,
0.03351811692118645,
0.15079115331172943,
-0.48249170184135437,
0.46614280343055725,
-0.584223747253418,
0.6989843249320984,
-0.6238943338394165,
-0.583158552646637,
-0.35494357347488403,
0.623282790184021,
0.6320911645889282,
0.1379701942205429,
-0.10747383534908295,
-0.31684595346450806,
0.21369418501853943,
0.2931036949157715,
-0.04533255472779274,
-0.44050440192222595,
-0.23424777388572693,
-0.2196708619594574,
0.014237810857594013,
-0.4532518684864044,
-0.1069415956735611,
-0.4014665484428406,
0.38523226976394653,
-0.31498873233795166,
0.05191968008875847,
0.42647844552993774,
0.336868017911911,
0.5735321044921875,
0.18076562881469727,
-0.1606959104537964,
-1.1272547245025635,
0.0685049518942833,
-0.36163172125816345,
0.27110135555267334,
0.26903030276298523,
0.6012862920761108,
0.5580463409423828,
-0.4400673806667328,
0.00463970797136426,
-0.3939715325832367,
0.5774595141410828,
-0.03262459114193916,
0.06867325305938721,
0.38878631591796875,
0.42415037751197815,
-0.503679096698761,
-0.5496927499771118,
0.3739466965198517,
0.05685821920633316,
-0.5269155502319336,
0.002065833657979965,
-0.20916369557380676,
-0.003963873255997896,
-0.12142473459243774,
-0.06053861230611801,
-0.2640521824359894,
-0.08220013976097107,
-0.2603059709072113
] |
BACKGROUND: Individual strategies in pandemic preparedness plans may not reduce the impact of an influenza pandemic. METHODS: We searched modeling publications through PubMed and associated references from 1990 to 30 September 2009. Inclusion criteria were modeling papers quantifying the effectiveness of combination strategies, both pharmaceutical and non-pharmaceutical. RESULTS: Nineteen modeling papers on combination strategies were selected. Four studies examined combination strategies on a global scale, 14 on single countries, and one on a small community. Stochastic individual-based modeling was used in nine studies, stochastic meta-population modeling in five, and deterministic compartmental modeling in another five. As part of combination strategies, vaccination was explored in eight studies, antiviral prophylaxis and/or treatment in 16, area or household quarantine in eight, case isolation in six, social distancing measures in 10 and air travel restriction in six studies. Two studies suggested a high probability of successful influenza epicenter containment with combination strategies under favorable conditions. During a pandemic, combination strategies delayed spread, reduced overall number of cases, and delayed and reduced peak attack rate more than individual strategies. Combination strategies remained effective at high reproductive numbers compared with single strategy. Global cooperative strategies, including redistribution of antiviral drugs, were effective in reducing the global impact and attack rates of pandemic influenza. CONCLUSION: Combination strategies increase the effectiveness of individual strategies. They include pharmaceutical (antiviral agents, antibiotics and vaccines) and non-pharmaceutical interventions (case isolation, quarantine, personal hygiene measures, social distancing and travel restriction). Local epidemiological and modeling studies are needed to validate efficacy and feasibility. | [
0.003752554301172495,
0.01880192942917347,
-0.008954597637057304,
0.029367640614509583,
0.027486369013786316,
-0.0016269529005512595,
0.00962468609213829,
-0.012305663898587227,
-0.016823766753077507,
-0.03951527178287506,
-0.015421167016029358,
0.02088300511240959,
-0.015225905925035477,
-0.005033025983721018,
-0.00743061862885952,
-0.005576403811573982,
0.0002552582882344723,
0.03670036792755127,
0.007734083104878664,
-0.004545314237475395,
-0.032132603228092194,
0.023944683372974396,
0.010648286901414394,
0.033947624266147614,
0.018042543902993202,
-0.0027974355034530163,
0.002146076411008835,
-0.004944797605276108,
-0.02503495290875435,
-0.02504391223192215,
0.02428058348596096,
0.012172171846032143,
0.02110598050057888,
0.014665070921182632,
-0.0018971317913383245,
0.024665847420692444,
-0.0031094581354409456,
0.017737390473484993,
-0.01029462181031704,
-0.0042665870860219,
0.0035922641400247812,
-0.01773763634264469,
-0.00582786463201046,
-0.019814297556877136,
-0.00568466167896986,
0.032246045768260956,
-0.007970338687300682,
0.013404974713921547,
-0.010264263488352299,
0.011234174482524395,
-0.01406643632799387,
-0.0022657220251858234,
-0.014451521448791027,
0.0017897409852594137,
-0.006677395198494196,
-0.0033647315576672554,
0.02158123441040516,
-0.009283190593123436,
-0.03286309912800789,
0.03511758893728256,
0.007006308529525995,
0.021320082247257233,
0.03141498193144798,
-0.030411554500460625,
-0.024185679852962494,
-0.06690837442874908,
0.028312476351857185,
0.017998136579990387,
0.00788036733865738,
-0.004377184901386499,
0.0023269513621926308,
0.015226807445287704,
-0.016117529943585396,
-0.01500438991934061,
-0.02581511065363884,
-0.002326488960534334,
0.0008759067859500647,
0.024660347029566765,
0.02147679589688778,
-0.0015383684076368809,
-0.0038631311617791653,
-0.0026589911431074142,
-0.013797588646411896,
0.02216443419456482,
0.01568223349750042,
0.025319062173366547,
-0.012569503858685493,
0.012526540085673332,
-0.012258674949407578,
0.018046632409095764,
0.032917335629463196,
-0.028895379975438118,
-0.0025882930494844913,
-0.00624110596254468,
0.003002374665811658,
-0.011472628451883793,
-0.03332492336630821,
0.026100531220436096,
-0.02489185705780983,
-0.010719982907176018,
-0.011587164364755154,
-0.0032940846867859364,
0.019572291523218155,
-0.006132969167083502,
0.009611574932932854,
0.011557524092495441,
-0.026545967906713486,
0.008099421858787537,
0.016331009566783905,
0.0008092506323009729,
0.008697578683495522,
0.01836150884628296,
0.01477715652436018,
-0.004868175834417343,
0.008371281437575817,
-0.015374874696135521,
-0.01210734061896801,
0.012611661106348038,
0.0073465341702103615,
0.008221181109547615,
0.012713907286524773,
-0.008375548757612705,
0.005831928923726082,
-0.00047579710371792316,
0.0038518845103681087,
0.005374109838157892,
0.015387635678052902,
-0.008454786613583565,
-0.0022682063281536102,
0.014284379780292511,
-0.009212340228259563,
-0.003399049863219261,
-0.00015924638137221336,
0.011376405134797096,
0.0022016349248588085,
0.001385373529046774,
-0.010957390069961548,
-0.0007432473357766867,
0.00010327529162168503,
0.0015987674705684185,
-0.026172958314418793,
0.014837479218840599,
-0.0036320509389042854,
0.020131690427660942,
0.015293443575501442,
0.006833166815340519,
0.012921497225761414,
0.004981597885489464,
0.01466864999383688,
0.013041899539530277,
0.02695055678486824,
0.004020710941404104,
-0.014652194455265999,
-0.018111199140548706,
-0.0008481349796056747,
0.005636466667056084,
0.011073834262788296,
-0.010142562910914421,
-0.017678143456578255,
-0.019402625039219856,
-0.032386213541030884,
-0.005112932529300451,
0.0030878675170242786,
0.007164726033806801,
0.037232059985399246,
0.02612234279513359,
0.000540328212082386,
0.0054139746353030205,
-0.026965193450450897,
-0.0017943225102499127,
-0.010465096682310104,
-0.0017879540100693703,
-0.012102791108191013,
0.012137741781771183,
0.02821977064013481,
-0.008864907547831535,
0.009361719712615013,
0.008045126684010029,
-0.002683906815946102,
0.06674986332654953,
0.004616909194737673,
-0.01100936345756054,
-0.004492449574172497,
0.011962011456489563,
-0.019775142893195152,
-0.009503723122179508,
0.05374252051115036,
-0.0053575485944747925,
-0.01739305630326271,
-0.01758752018213272,
0.004001423716545105,
-0.023382652550935745,
0.007424578070640564,
-0.021876385435461998,
-0.024202514439821243,
0.003275600727647543,
-0.0045809634029865265,
-0.004507104400545359,
0.009655054658651352,
-0.01646427996456623,
0.036583662033081055,
0.009259376674890518,
0.040949735790491104,
0.007322517689317465,
-0.01801111362874508,
0.0183086097240448,
0.013305079191923141,
-0.00965827889740467,
0.007173406425863504,
-0.0035604629665613174,
0.012096354737877846,
-0.041320785880088806,
0.015552920289337635,
-0.011442502960562706,
-0.014282656833529472,
0.0004979174118489027,
-0.002510874532163143,
0.033491864800453186,
0.006103187333792448,
-0.016391705721616745,
0.0036245379596948624,
-0.0003935780841857195,
-0.01099160872399807,
-0.032658811658620834,
0.0148137416690588,
-0.007641782984137535,
-0.004227272234857082,
0.013204708695411682,
-0.017506564036011696,
-0.0064041027799248695,
-0.013083325698971748,
0.019192613661289215,
-0.011691754683852196,
-0.030985761433839798,
0.032148897647857666,
0.011022066697478294,
0.013010977767407894,
-0.00898626260459423,
0.013056742958724499,
-0.013048350811004639,
-0.012128916569054127,
-0.024553261697292328,
0.02021775022149086,
0.011496365070343018,
-0.006327828858047724,
0.0069685825146734715,
0.04402966797351837,
-0.005855868570506573,
-0.0019130082800984383,
-0.00899156928062439,
0.004052500706166029,
-0.012049287557601929,
0.0021279463544487953,
-0.010032445192337036,
0.02868080511689186,
0.016217362135648727,
0.018104247748851776,
0.028280768543481827,
0.025432325899600983,
0.005364127457141876,
0.013220885768532753,
0.00451959203928709,
-0.030759043991565704,
-0.006412898190319538,
0.012030679732561111,
-0.0019686780869960785,
0.023691590875387192,
0.001978290267288685,
0.0011298141907900572,
0.01484411209821701,
0.0037558756303042173,
-0.01135779358446598,
-0.00779421953484416,
-0.08143182098865509,
-0.005018120631575584,
-0.008305148221552372,
-0.01478588581085205,
0.00968121737241745,
-0.03082098253071308,
0.009732669219374657,
0.02217709645628929,
-0.014352187514305115,
0.02159743197262287,
-0.003265711013227701,
0.009280800819396973,
-0.009249590337276459,
0.01914653368294239,
0.007326736114919186,
0.004123691003769636,
0.005425631534308195,
0.045532092452049255,
-0.003099488327279687,
-0.009341106750071049,
-0.017905892804265022,
-0.012576808221638203,
0.019765254110097885,
-0.019570564851164818,
-0.015781311318278313,
0.005690958816558123,
0.013631247915327549,
0.0007460929336957633,
0.014174336567521095,
0.01085366029292345,
0.014940825290977955,
-0.04165047034621239,
-0.035137467086315155,
-0.012941371649503708,
0.002267196075990796,
0.02408652752637863,
0.006344950757920742,
-0.010732856579124928,
0.006229206919670105,
-0.004497506655752659,
0.007804752327501774,
-0.0045034512877464294,
0.0047316402196884155,
-0.0018577204318717122,
0.0065172770991921425,
0.016258755698800087,
-0.01589123159646988,
0.016598165035247803,
0.018360547721385956,
0.028927724808454514,
-0.01657770574092865,
-0.00875367783010006,
0.018505072221159935,
0.017051834613084793,
-0.003577093593776226,
-0.005731840152293444,
-0.002612846903502941,
0.02141674980521202,
-0.009300868958234787,
-0.010560812428593636,
-0.007578928489238024,
0.02303333394229412,
0.011492697522044182,
0.014599896036088467,
-0.034006621688604355,
-0.032635897397994995,
0.005115346983075142,
0.006750035099685192,
0.008206978440284729,
-0.0020875497721135616,
-0.010237455368041992,
0.0044829207472503185,
0.027879226952791214,
-0.004262777976691723,
0.018882205709815025,
-0.018044643104076385,
-0.013376283459365368,
-0.024791894480586052,
0.008420205675065517,
0.008516483008861542,
0.006715848576277494,
0.017823895439505577,
0.005075134336948395,
0.002208686200901866,
-0.03217591717839241,
-0.011531105265021324,
0.008314451202750206,
-0.020924460142850876,
0.016543537378311157,
-0.024808820337057114,
-0.017587337642908096,
0.012487879954278469,
-0.009304767474532127,
0.005714736878871918,
-0.0064202724024653435,
-0.02330559305846691,
-0.013722633942961693,
-0.010374652221798897,
-0.002280470449477434,
0.009794918820261955,
0.011376885697245598,
-0.009321924299001694,
0.0011307569220662117,
-0.014189831912517548,
-0.04272456467151642,
0.01141373347491026,
-0.00020644045434892178,
-0.041242532432079315,
-0.03467841446399689,
-0.009059691801667213,
-0.0175214521586895,
0.005973938852548599,
0.0014869073638692498,
0.035194236785173416,
0.011530594900250435,
0.0026638146955519915,
0.014802420511841774,
0.006336518097668886,
0.0719735324382782,
0.004135599825531244,
0.005657249130308628,
-0.012030437588691711,
0.018674802035093307,
-0.021945197135210037,
-0.005395677872002125,
-0.018034644424915314,
0.03284261003136635,
-0.03527287393808365,
0.01331401988863945,
-0.026771117001771927,
0.014499040320515633,
-0.009254494681954384,
-0.017131365835666656,
-0.010953545570373535,
-0.008081631734967232,
-0.002558391774073243,
0.018315425142645836,
-0.01216752640902996,
-0.008186259306967258,
-0.015544179826974869,
-0.009876012802124023,
-0.010404735803604126,
-0.0034660142846405506,
-0.018394287675619125,
0.005600662901997566,
-0.015571452677249908,
0.004214787390083075,
0.0026499719824641943,
0.014685411937534809,
0.0057953130453825,
-0.004894468933343887,
-0.01072457991540432,
0.004155172035098076,
0.01700892671942711,
0.005697786342352629,
0.009021970443427563,
-0.004059620667248964,
0.006918816361576319,
-0.0227058082818985,
-0.018435681238770485,
-0.014578172005712986,
0.006075689103454351,
-0.028714515268802643,
0.0269106924533844,
0.006983262952417135,
-0.010141551494598389,
-0.02656756155192852,
0.004134956747293472,
-0.0016438430175185204,
0.016207154840230942,
0.00981980562210083,
0.04071149230003357,
-0.012208301573991776,
-0.0029209982603788376,
0.010588896460831165,
-0.002092431066557765,
0.003937934525310993,
0.006606960669159889,
-0.014099884778261185,
-0.0222492478787899,
0.00961113628000021,
-0.012901730835437775,
0.0045188311487436295,
-0.025198359042406082,
-0.01056581363081932,
0.012777483090758324,
-0.006102277897298336,
-0.026236670091748238,
-0.005427899770438671,
-0.027104776352643967,
0.007483754772692919,
0.01862316206097603,
-0.008011545054614544,
-0.001037612440995872,
-0.026935070753097534,
-0.01836099848151207,
-0.022716930136084557,
-0.013324110768735409,
-0.01979258842766285,
0.011448049917817116,
0.00010703527368605137,
-0.029526716098189354,
-0.0003643014933913946,
-0.011133994907140732,
-0.011247132904827595,
-0.07444847375154495,
-0.01741042360663414,
0.01944602280855179,
-0.011341046541929245,
0.004996579606086016,
0.0068936883471906185,
-0.017311060801148415,
-0.0037811370566487312,
0.0017260722815990448,
-0.0027269702404737473,
0.002635836135596037,
0.018391024321317673,
0.021669451147317886,
-0.002428647829219699,
0.013741979375481606,
0.015592400915920734,
-0.014292459934949875,
-0.00030459905974566936,
-0.011641831137239933,
0.010025146417319775,
-0.0006894432008266449,
0.022150130942463875,
-0.029589982703328133,
-0.013429969549179077,
0.01492273062467575,
-0.08070945739746094,
-0.007654077373445034,
0.0007604553829878569,
-0.0037868893705308437,
-0.011080464348196983,
0.012777866795659065,
0.03169357776641846,
-0.02439534291625023,
-0.016660992056131363,
-0.015640731900930405,
-0.009674572385847569,
-0.010169798508286476,
-0.017397770658135414,
-0.008381621912121773,
0.02832077443599701,
0.004017326980829239,
0.02699390798807144,
0.005085657816380262,
0.028383957222104073,
-0.046991124749183655,
0.03325141966342926,
-0.000785251148045063,
-0.0062468089163303375,
-0.005460256710648537,
-0.004620006307959557,
-0.01601591147482395,
-0.005236937198787928,
0.008883151225745678,
0.015887923538684845,
-0.029726378619670868,
-0.0018195341108366847,
0.006063488312065601,
0.004282541573047638,
0.02105715125799179,
-0.007104355376213789,
-0.012186584994196892,
0.012173393741250038,
-0.02253207005560398,
0.0021704640239477158,
-0.0028528471011668444,
-0.001705253031104803,
0.04092852771282196,
-0.02344907820224762,
0.0014794070739299059,
-0.005279998295009136,
0.0023435368202626705,
0.007430954836308956,
-0.0089094964787364,
0.02825780212879181,
0.003932040184736252,
0.008861901238560677,
-0.016756990924477577,
-0.0003480183077044785,
-0.006004284135997295,
-0.011069661006331444,
0.0033863061107695103,
-0.007844466716051102,
-0.007534421049058437,
0.007488023955374956,
0.017430711537599564,
0.001138386083766818,
0.010366365313529968,
-0.0036016975063830614,
0.0717720240354538,
-0.027280891314148903,
0.02947162836790085,
-0.032304998487234116,
-0.01797647587954998,
-0.004270387813448906,
0.01650763303041458,
-0.025713739916682243,
-0.015172149986028671,
-0.02293597348034382,
0.012180034071207047,
-0.012636017054319382,
0.0038580219261348248,
0.010057513602077961,
0.007626379374414682,
0.0011937562376260757,
0.018032047897577286,
0.002281780820339918,
0.012330126017332077,
0.02356012910604477,
-0.009761767461895943,
-0.007011239416897297,
-0.02977006323635578,
0.014235087670385838,
0.02256283536553383,
-0.017441757023334503,
-0.020389094948768616,
-0.021172810345888138,
-0.016284864395856857,
0.008388742804527283,
0.0032804328948259354,
-0.01091530080884695,
0.00853550061583519,
-0.005973810330033302,
0.0160068329423666,
-0.009945179335772991,
0.024615861475467682,
0.006298519205302,
-0.0014905778225511312,
0.013261433690786362,
-0.0028592697344720364,
-0.013443836942315102,
0.01187080703675747,
-0.01885409466922283,
-0.0026836516335606575,
-0.008814816363155842,
-0.010442063212394714,
-0.015814244747161865,
-0.011732412502169609,
0.00546127837151289,
-0.013795187696814537,
0.0009170976700261235,
0.02277858927845955,
-0.003176204627379775,
0.0030855333898216486,
0.019913069903850555,
0.005544766783714294,
0.019271422177553177,
-0.001667564269155264,
-0.0337175577878952,
-0.015885528177022934,
-0.007005194667726755,
0.027665672823786736,
-0.006015432998538017,
0.005505888722836971,
0.010473624803125858,
-0.0025041166227310896,
-0.009986413642764091,
0.013756349682807922,
0.01037481240928173,
-0.016248628497123718,
0.012955962680280209,
0.0025803353637456894,
-0.006305858492851257,
0.012308444827795029,
0.008163681253790855,
0.019681517034769058,
-0.0020745648071169853,
0.014195933938026428,
-0.008045182563364506,
-0.018627015873789787,
-0.021375417709350586,
-0.004125969484448433,
-0.02198394387960434,
0.018332626670598984,
-0.004689660854637623,
0.021018557250499725,
0.015705052763223648,
-0.008152320981025696,
0.008702872321009636,
0.01895195245742798,
0.016790978610515594,
-0.0024344457779079676,
-0.008887379430234432,
0.0067240213975310326,
0.03485598787665367,
0.006321953609585762,
0.003925464116036892,
0.0211593396961689,
0.012069450691342354,
-0.0007746187038719654,
-0.01484058890491724,
0.01562230009585619,
0.004967695567756891,
-0.0077857812866568565,
0.0031478460878133774,
0.01844334416091442,
0.014009376987814903,
0.004345213063061237,
0.02216830849647522,
-0.006916516460478306,
-0.01179422251880169,
0.01098167896270752,
-0.007610303349792957,
-0.00011770986020565033,
0.01927289366722107,
-0.004894955549389124,
0.01302769873291254,
0.0005259956233203411,
-0.00913037359714508,
-0.027119843289256096,
-0.0005055060610175133,
-0.012589724734425545,
0.04078016057610512,
-0.0022061369381844997,
0.003995812498033047,
-0.012027563527226448,
0.011042418889701366,
-0.016473712399601936,
0.0025635468773543835,
0.010316281579434872,
0.013243861496448517,
0.0002836775965988636,
0.012233778834342957,
0.000694090616889298,
0.0046879868023097515,
0.006340841297060251,
-0.016605179756879807,
-0.0017693700501695275,
-0.00525771826505661,
0.027927229180932045,
0.009150308556854725,
0.0027130867820233107,
-0.012042883783578873,
0.011745447292923927,
-0.008871451951563358,
0.0030629774555563927,
0.010589024052023888,
0.006726558320224285,
-0.019712034612894058,
-0.01471300981938839,
0.007811389863491058,
0.02118954062461853,
0.0005206880159676075,
0.0075368015095591545,
0.011600565165281296,
0.012331817299127579,
0.004907234571874142,
-0.036572135984897614,
-0.005080405622720718,
-0.0020946566946804523,
-0.010471183806657791,
0.020882658660411835,
0.005430200602859259,
-0.004204927943646908,
-0.007060242351144552,
0.013252980075776577,
0.03725700080394745,
-0.008547362871468067,
-0.001395240775309503,
0.0016285036690533161,
-0.013778789900243282,
-0.01318674348294735,
0.01402873545885086,
-0.014463400468230247,
-0.0015381218399852514,
-0.005087451543658972,
0.009291807189583778,
-0.03570224717259407,
0.012467728927731514,
0.033646345138549805,
-0.004307635128498077,
-0.0037126950919628143,
-0.010226225480437279,
0.00597005570307374,
-0.00042798882350325584,
-0.005310406908392906,
0.007743369787931442,
0.0009618579060770571,
0.03428957983851433,
-0.002451858948916197,
0.020600728690624237,
-0.013860835693776608,
0.01304437592625618,
0.012247134000062943,
-0.03112201765179634,
-0.003637491725385189,
-0.0265349131077528,
0.004842763300985098,
0.014666378498077393,
0.023476634174585342,
-0.0016737057594582438
] | [
0.15945902466773987,
-0.18950727581977844,
-0.25171488523483276,
-0.13564321398735046,
-0.0003453358949627727,
0.74555903673172,
0.31340914964675903,
-0.4174852967262268,
-0.4700625538825989,
-0.49340999126434326,
0.14852368831634521,
0.3612596094608307,
-0.31772640347480774,
-0.184354767203331,
-0.10080981999635696,
0.4686078727245331,
0.6459993720054626,
0.16279378533363342,
-0.11556537449359894,
-0.19579602777957916,
-0.29976120591163635,
-0.06573227047920227,
0.1576102077960968,
-0.05957164242863655,
-0.09393816441297531,
0.3223190903663635,
0.5155935883522034,
-0.0177582036703825,
0.45815256237983704,
0.3730826675891876,
0.2081541270017624,
0.6405898332595825,
0.2523816227912903,
-0.2588154673576355,
0.12730829417705536,
-0.06914064288139343,
-0.004686199128627777,
-0.0062044402584433556,
0.15380200743675232,
-0.5594167709350586,
-0.0559271015226841,
-0.04417470470070839,
-0.10340642929077148,
0.3752792477607727,
-0.10781877487897873,
-0.594364583492279,
-1.7906577587127686,
0.11977067589759827,
-0.07612520456314087,
0.055159226059913635,
0.2918022871017456,
0.17115792632102966,
0.009840269573032856,
0.06719249486923218,
-0.2999582886695862,
0.6930635571479797,
-0.2766808271408081,
-0.05756179243326187,
0.0705987885594368,
-0.2586691677570343,
-0.15669339895248413,
-0.30467790365219116,
0.22221648693084717,
0.3898724615573883,
-0.38021087646484375,
0.2546237111091614,
0.33593595027923584,
0.36082690954208374,
-0.12489357590675354,
-0.23266738653182983,
-0.23928703367710114,
-0.06779467314481735,
0.09488456696271896,
0.15554089844226837,
-0.566174328327179,
-0.19657590985298157,
0.0027683740481734276,
-0.21109408140182495,
0.2782345712184906,
-0.09367986768484116,
0.28118976950645447,
-0.08115221560001373,
0.2246055006980896,
-0.5577025413513184,
0.7465812563896179,
0.20026655495166779,
-0.12048128247261047,
0.4112425148487091,
-0.4524811804294586,
0.05811768025159836,
0.02220548316836357,
-0.3192969560623169,
0.43472298979759216,
0.6117699146270752,
0.2264849990606308,
0.35601839423179626,
-0.1657816767692566,
-0.07322628051042557,
0.216196671128273,
-0.010110603645443916,
0.29439494013786316,
0.1791316121816635,
0.1956649273633957,
-0.3330196440219879,
-0.5208107233047485,
-0.3308331370353699,
-0.08033475279808044,
-0.9411114454269409,
-0.4290270209312439,
0.10336831957101822,
-0.7178909182548523,
0.2811987102031708,
0.06983593851327896,
-0.20616500079631805,
-0.24619470536708832,
0.6684839725494385,
-0.041700996458530426,
0.10389304906129837,
-0.0322873555123806,
0.36025840044021606,
-0.10355419665575027,
0.9304236173629761,
-0.08126769214868546,
0.46315205097198486,
0.3154934346675873,
0.1210901290178299,
0.4489137828350067,
-0.06529423594474792,
-0.4628085792064667,
0.11168817430734634,
-0.025673700496554375,
0.43433117866516113,
-0.5678310990333557,
0.31676846742630005,
-0.13638925552368164,
-0.05538357049226761,
0.16708041727542877,
0.5595923662185669,
0.40324831008911133,
0.1055092066526413,
-0.36484020948410034,
-0.5482377409934998,
-0.27948105335235596,
-0.26043668389320374,
0.21386192739009857,
-0.12655502557754517,
0.2848328649997711,
-0.39644578099250793,
-0.4989861249923706,
-0.023708254098892212,
-0.04492576792836189,
0.04447732865810394,
-0.02059037983417511,
0.054981570690870285,
-0.05624916031956673,
1.0758808851242065,
-0.6387811303138733,
-0.25768041610717773,
-0.01845688372850418,
-0.2944355905056,
0.49822601675987244,
0.330265611410141,
-0.16459135711193085,
-0.04905437305569649,
-0.0061499630101025105,
-0.27095726132392883,
-0.1561378538608551,
0.33649012446403503,
-0.1820521056652069,
-0.0015833579236641526,
-0.14609217643737793,
0.05223574489355087,
0.17485587298870087,
-0.3855424225330353,
0.018760472536087036,
0.1715886890888214,
0.5767008066177368,
0.2753713130950928,
0.6140298843383789,
0.034153468906879425,
-0.40224361419677734,
-0.21782727539539337,
0.3710308372974396,
-0.8130537271499634,
0.42232468724250793,
-0.0008618341526016593,
0.559792697429657,
0.1017465889453888,
0.3259614408016205,
0.434533029794693,
-0.41706594824790955,
-0.2487049251794815,
0.21614296734333038,
-0.8637977838516235,
1.6122597455978394,
-0.35969704389572144,
-0.48755118250846863,
0.9755415916442871,
0.024165144190192223,
-0.17271412909030914,
0.363533616065979,
0.1179327592253685,
0.5061864852905273,
-0.004217945039272308,
-0.37064504623413086,
-0.2188076376914978,
-0.16213086247444153,
-0.46200963854789734,
-0.3777150511741638,
0.19071581959724426,
0.40917202830314636,
-0.23043304681777954,
-0.45615947246551514,
-0.18823298811912537,
0.21256807446479797,
0.37049877643585205,
0.009999568574130535,
0.91595858335495,
0.13173848390579224,
-0.034345705062150955,
0.8922325968742371,
-0.6983965039253235,
0.032867707312107086,
0.4354935884475708,
0.3442448675632477,
0.4741600751876831,
0.650066614151001,
0.0395185761153698,
0.7219722270965576,
-0.5797907114028931,
0.27141517400741577,
-0.20436155796051025,
0.419965535402298,
-0.4782901406288147,
-0.023658107966184616,
-0.12819436192512512,
-0.18735380470752716,
0.32734614610671997,
-0.23890280723571777,
-0.18507975339889526,
0.3145349621772766,
0.2804725468158722,
-0.6797868609428406,
-0.17438608407974243,
0.1171303540468216,
-0.11763521283864975,
-0.20695191621780396,
-0.03881870582699776,
-0.5821784138679504,
0.058835286647081375,
-0.07488913834095001,
0.2194616049528122,
0.3483814001083374,
-0.3733136057853699,
0.11298725008964539,
0.20613376796245575,
0.178916335105896,
-0.5398827195167542,
-0.032401468604803085,
-0.26111331582069397,
-0.06227729469537735,
0.09701313078403473,
0.48439517617225647,
0.09784483164548874,
0.42982494831085205,
-0.613322377204895,
-0.6994370222091675,
-0.48021969199180603,
0.1498567909002304,
0.4292205572128296,
0.6531282067298889,
0.07017767429351807,
-0.45633527636528015,
0.27331027388572693,
0.12706008553504944,
-0.9416704177856445,
0.05556066706776619,
0.5849485993385315,
-0.8622592091560364,
-0.5226290822029114,
-0.007334546186029911,
0.5429241061210632,
0.6521568298339844,
-0.3112269341945648,
-0.04243749380111694,
-0.5089698433876038,
-0.13835707306861877,
-0.023653341457247734,
-0.3444144129753113,
0.17220473289489746,
0.13283272087574005,
0.4010104537010193,
-0.3411157727241516,
-0.516139805316925,
0.11751639097929001,
0.12528400123119354,
-0.36632654070854187,
0.7978855967521667,
0.5063388347625732,
0.6432393193244934,
0.0736173689365387,
0.16005542874336243,
-0.09964447468519211,
-0.05331902205944061,
0.16861365735530853,
-0.3791790306568146,
-0.349261075258255,
0.3563413619995117,
-5.989407539367676,
-0.26938262581825256,
-0.37197503447532654,
0.03774941712617874,
-0.0259956456720829,
0.34745287895202637,
0.8031834363937378,
-0.05014169216156006,
0.31064918637275696,
-0.06564031541347504,
0.2240963727235794,
0.26776036620140076,
0.16881820559501648,
0.26271623373031616,
0.20337851345539093,
0.33341872692108154,
0.22015728056430817,
0.052743278443813324,
0.25525298714637756,
0.14212417602539062,
0.4938706159591675,
-0.6407113671302795,
-0.3639996349811554,
0.5744529366493225,
0.0894809141755104,
0.1727403700351715,
-0.9432753324508667,
0.19672703742980957,
-0.32217690348625183,
0.2248033583164215,
0.04758923873305321,
-0.45348605513572693,
-0.5363402962684631,
-0.12804648280143738,
0.014150317758321762,
0.102029949426651,
0.30141815543174744,
0.09918595850467682,
-0.031604357063770294,
-0.21292437613010406,
0.507675051689148,
0.4016200006008148,
-0.24927617609500885,
-0.500081479549408,
0.09519100189208984,
-0.06391771882772446,
0.30152976512908936,
0.39973124861717224,
-0.4634637236595154,
0.5893682837486267,
0.08674413710832596,
-0.10299047827720642,
0.27346935868263245,
0.4136602282524109,
0.06406137347221375,
-0.2514530420303345,
-0.2743736803531647,
0.6951869130134583,
0.4302162826061249,
0.6036891341209412,
0.4295521080493927,
-0.3968336284160614,
0.08017556369304657,
-0.8233253359794617,
-0.29224514961242676,
-0.07300624996423721,
-0.8454590439796448,
-0.6206286549568176,
0.22476837038993835,
0.20923683047294617,
-0.5082190036773682,
-0.01254499051719904,
0.2491074800491333,
-0.5885356068611145,
0.1254705935716629,
-0.36986830830574036,
0.36294442415237427,
-0.1741708219051361,
0.09330347180366516,
0.099224753677845,
-0.20349204540252686,
-0.24168404936790466,
0.4542674422264099,
-0.15337388217449188,
0.15320569276809692,
0.06698960810899734,
-0.5231374502182007,
0.24528846144676208,
-0.36777105927467346,
0.15697379410266876,
0.38448551297187805,
-0.1103726178407669,
0.09715303033590317,
0.4977423846721649,
0.6323389410972595,
0.7004444599151611,
0.23656409978866577,
0.009668934158980846,
0.18953374028205872,
-0.31523385643959045,
0.510791540145874,
0.03582668676972389,
-0.2347586750984192,
-0.8639825582504272,
-0.09268322587013245,
0.0758417546749115,
-0.7134308218955994,
-0.33593928813934326,
0.6116987466812134,
-0.3541010916233063,
-0.20371319353580475,
-0.15101484954357147,
-0.025025328621268272,
-0.24995356798171997,
0.4320361912250519,
-0.38239628076553345,
-0.19865632057189941,
0.1611003428697586,
0.5615808367729187,
0.07962258160114288,
-0.06896094232797623,
0.18793173134326935,
-0.2663743793964386,
0.30818840861320496,
0.18908582627773285,
-0.6842447519302368,
-0.13009858131408691,
-0.06024429202079773,
-0.479824960231781,
-0.06514258682727814,
0.26577138900756836,
0.40805020928382874,
-0.5484182238578796,
-0.13834787905216217,
0.29360517859458923,
-0.6302737593650818,
-0.6767513155937195,
0.30178266763687134,
-0.11309421807527542,
0.036951761692762375,
0.08715439587831497,
-0.09202175587415695,
-0.1926378607749939,
-0.08309286087751389,
-0.1876455545425415,
0.0270322784781456,
0.13403955101966858,
-0.22982388734817505,
0.08695412427186966,
0.09213016927242279,
0.22672951221466064,
0.04299990087747574,
0.04383539780974388,
-0.1021282821893692,
-0.636064350605011,
-0.007111633662134409,
0.5806705355644226,
-0.017574498429894447,
0.18007677793502808,
-0.5827863812446594,
0.4726838171482086,
0.15045884251594543,
-1.1322553157806396,
-0.06252466142177582,
0.0061326539143919945,
-0.0743543952703476,
-0.12032879143953323,
-0.027899259701371193,
0.18902958929538727,
0.13853685557842255,
-0.159150168299675,
-0.8700973987579346,
0.09245625883340836,
-0.07767404615879059,
-0.08845594525337219,
0.28061506152153015,
0.19973894953727722,
-0.37129998207092285,
-0.4962063133716583,
0.31799471378326416,
0.3278540372848511,
-0.5375311970710754,
-0.6172195076942444,
0.25104814767837524,
0.6526270508766174,
0.5661368370056152,
0.10116860270500183,
-0.44154176115989685,
-0.22594189643859863,
-0.44414401054382324,
0.17410540580749512,
0.1002020537853241,
0.649398148059845,
-0.16615529358386993,
-0.39888688921928406,
-0.5119969844818115,
-0.29046595096588135,
0.31315094232559204,
-0.12909053266048431,
-0.33061209321022034,
-0.055411577224731445,
0.6740615367889404,
-0.6297326683998108,
0.09959428757429123,
0.5806113481521606,
-0.7731707096099854,
-0.21920810639858246,
-0.24439974129199982,
0.38204333186149597,
-0.43839019536972046,
-0.22209998965263367,
-0.3399425148963928,
-0.6610909104347229,
0.3263120949268341,
-0.28127938508987427,
0.591705322265625,
-0.12663689255714417,
-0.5232742428779602,
-0.41737452149391174,
0.4866701662540436,
0.16564977169036865,
-0.5077910423278809,
-0.6341897249221802,
-0.08363144099712372,
-0.3778908848762512,
0.35795336961746216,
0.3328745663166046,
-0.6980225443840027,
-0.21947820484638214,
-0.04546641185879707,
-0.683339536190033,
-0.18101784586906433,
-0.09155984222888947,
0.049648482352495193,
-0.49572935700416565,
-0.45084235072135925,
-0.23963002860546112,
-0.33050209283828735,
0.1715272068977356,
0.10840041935443878,
-0.4352199137210846,
0.6087546348571777,
-0.12086088955402374,
-0.39791765809059143,
-0.17630547285079956,
-0.3424113988876343,
0.36885082721710205,
-0.614292323589325,
-0.3385789096355438,
-0.2680237591266632,
-0.1616840660572052,
-0.42431938648223877,
0.32639750838279724,
-0.35811498761177063,
0.6224874258041382,
0.5299766659736633,
-0.3862389624118805,
-0.339589387178421,
-0.22402802109718323,
-0.051497749984264374,
-0.15727685391902924,
0.15200817584991455,
-0.4637671411037445,
-0.5704768300056458,
0.6772226691246033,
-0.11156512051820755,
-0.16211582720279694,
-0.32040733098983765,
0.025421449914574623,
-0.6160029768943787,
0.23849932849407196,
0.19629566371440887,
0.3392919600009918,
0.9474000930786133,
0.4368008077144623,
0.14752408862113953,
0.10165376216173172,
-0.09304817020893097,
0.33483758568763733,
0.36314940452575684,
-0.6091974377632141,
-0.40986010432243347,
0.061702970415353775,
0.08681019395589828,
0.38694897294044495,
-0.7153138518333435,
0.09003352373838425,
-0.35081398487091064,
-0.10756973177194595,
-0.563186764717102,
0.10947730392217636,
0.4144362509250641,
-0.6787512302398682,
-0.1854352355003357,
-0.164347305893898,
0.40407052636146545,
0.061992086470127106,
0.11915219575166702,
-0.21021781861782074,
-0.32407522201538086,
-0.1356586068868637,
0.48624318838119507,
0.6175976991653442,
-0.44833794236183167,
0.10123509168624878,
0.3080747425556183,
0.3439851999282837,
0.09997322410345078,
0.17936469614505768,
-0.059090446680784225,
0.39478716254234314,
-0.28977397084236145,
0.24980458617210388,
0.4758685827255249,
-0.782267689704895,
-0.010722783394157887,
-0.4999372363090515,
-0.5975501537322998,
0.7031413912773132,
0.18388165533542633,
0.3218437433242798,
0.9044563174247742,
0.4679112434387207,
-0.3414664566516876,
-0.4881778061389923,
0.6981247067451477,
0.026363074779510498,
0.46985289454460144,
0.07163118571043015,
0.18281057476997375,
0.47069019079208374,
0.6005606651306152,
-0.07389126718044281,
-0.11685844510793686,
0.1992367058992386,
0.16555234789848328,
0.3330436050891876,
-0.3983900845050812,
-0.1722479611635208,
-0.005369557533413172,
0.9016904830932617,
0.11091162264347076,
0.10106737911701202,
0.05462874472141266,
-0.22855843603610992,
0.190419003367424,
0.1884588897228241,
0.2062331587076187,
0.12366737425327301,
0.3095864951610565,
0.11754431575536728,
0.4836711585521698,
-0.008789603598415852,
0.20296159386634827,
0.01436825841665268,
-0.061754241585731506,
0.24916936457157135,
-0.15062004327774048,
-0.09425888955593109,
-0.0722149908542633,
0.614888072013855,
0.4773504137992859,
-0.5689591765403748,
0.039806582033634186,
-0.34649381041526794,
0.05649343132972717,
0.6891509294509888,
0.3029158413410187,
-0.22290164232254028,
0.15256856381893158,
-0.06394894421100616,
0.012134739197790623,
-0.35753563046455383,
0.46622350811958313,
-0.31316840648651123,
-0.43954041600227356,
0.33745864033699036,
0.018179774284362793,
0.09698426723480225,
0.41339758038520813,
-0.24049022793769836,
-0.1726733148097992,
-0.12872722744941711,
-0.2854591906070709,
0.01820838265120983,
0.09659653156995773,
-0.4583131968975067,
0.4583609104156494,
0.7122936248779297,
0.015128259547054768,
0.1723465770483017,
-0.6584550738334656,
-0.06769167631864548,
0.1016819179058075,
0.39426931738853455,
-0.18952614068984985,
-0.26782628893852234,
0.7413687109947205,
0.21419379115104675,
0.14489421248435974,
0.06805209070444107,
-0.3331608772277832,
-0.298258513212204,
0.7142594456672668,
0.11275757104158401,
0.4237103760242462,
-0.4189116656780243,
0.05161416530609131,
-0.3964858949184418,
0.05808661878108978,
0.3658742904663086,
-0.0029349452815949917,
-0.34905388951301575,
-0.1582585871219635,
-0.3526148796081543,
0.19108185172080994,
0.6496041417121887,
-0.3036518096923828,
-0.03336191549897194,
-0.5206577181816101,
0.034773267805576324,
-0.3448171615600586,
0.32873713970184326,
-0.23793672025203705,
-0.7150042057037354,
-0.03821161761879921,
0.478678822517395,
0.6436545848846436,
-0.21863321959972382,
0.856532096862793,
-0.06518401950597763,
-0.15833905339241028,
-0.3646083176136017,
0.25306791067123413,
-0.7665050625801086,
0.002977356780320406,
0.3163476288318634,
0.356372594833374,
-0.02171570062637329,
-0.09718931466341019,
-0.411644846200943,
-0.33739468455314636,
0.1064220443367958,
0.1007164940237999,
-0.0030254563316702843,
0.1071837991476059,
0.18857690691947937,
0.04718133434653282,
-0.27600976824760437,
0.4970116913318634,
-0.4100947678089142,
-0.15497711300849915,
-0.4932589828968048,
-0.149356409907341,
-0.3197322189807892,
0.3139924705028534,
-0.2615262269973755,
-0.6016770601272583,
-0.2783525884151459,
-0.1496192216873169
] |
BACKGROUND: Streptococcus pneumoniae is a common cause of community acquired pneumonia and bacteremia. Excess wintertime mortality related to pneumonia has been noted for over a century, but the seasonality of invasive pneumococcal disease (IPD) has been described relatively recently and is poorly understood. Improved understanding of environmental influence on disease seasonality has taken on new urgency due to global climate change. METHODS: We evaluated 602 cases of IPD reported in Philadelphia County, Pennsylvania, from 2002 to 2007. Poisson regression models incorporating seasonal smoothers were used to identify associations between weekly weather patterns and case counts. Associations between acute (day-to-day) environmental fluctuations and IPD occurrence were evaluated using a case-crossover approach. Effect modification across age and sex strata was explored, and meta-regression models were created using stratum-specific estimates for effect. RESULTS: IPD incidence was greatest in the wintertime, and spectral decomposition revealed a peak at 51.0 weeks, consistent with annual periodicity. After adjustment for seasonality, yearly increases in reporting, and temperature, weekly incidence was found to be associated with clear-sky UV index (IRR per unit increase in index: 0.70 [95% CI 0.54-0.91]). The effect of UV index was highest among young strata and decreased with age. At shorter time scales, only an association with increases in ambient sulphur oxides was linked to disease risk (OR for highest tertile of exposure 0.75, 95% CI 0.60 to 0.93). CONCLUSION: We confirmed the wintertime predominance of IPD in a major urban center. The major predictor of IPD in Philadelphia is extended periods of low UV radiation, which may explain observed wintertime seasonality. The mechanism of action of diminished light exposure on disease occurrence may be due to direct effects on pathogen survival or host immune function via altered 1,25-(OH)(2)-vitamin-D metabolism. These findings may suggest less diminution in future IPD risk with climate change than would be expected if wintertime seasonality was driven by temperature. | [
-0.0040399180725216866,
0.000534676481038332,
-0.004027658142149448,
0.016947951167821884,
0.02476915717124939,
0.003474852768704295,
0.008825194090604782,
0.025304274633526802,
-0.013101432472467422,
-0.002951436210423708,
-0.001741732470691204,
0.0170745812356472,
-0.009452668018639088,
0.010403135791420937,
0.006466866470873356,
0.008231081068515778,
-0.0026084568817168474,
0.015038399957120419,
0.012966056354343891,
-0.01693258434534073,
0.010045766830444336,
-0.008422916755080223,
0.008789688348770142,
0.018099725246429443,
-0.013255876488983631,
-0.0090157650411129,
-0.0005158181302249432,
-0.012164083309471607,
-0.018495390191674232,
-0.004046982154250145,
0.014616042375564575,
0.012409658171236515,
-0.001804136554710567,
0.008515776135027409,
0.0017859631916508079,
-0.006384999491274357,
-0.0035148661118000746,
0.013326413929462433,
-0.021574728190898895,
-0.004509743768721819,
-0.016384119167923927,
-0.014169384725391865,
0.0030108606442809105,
-0.012668062001466751,
-0.007621630094945431,
0.020077042281627655,
-0.004739526659250259,
-0.021037118509411812,
-0.008622364141047001,
0.0052824001759290695,
-0.012020482681691647,
0.017690643668174744,
-0.00865428987890482,
-0.028598591685295105,
-0.005933514796197414,
-0.0075890859588980675,
0.017082886770367622,
0.030230246484279633,
-0.01941082254052162,
0.005911267362535,
0.03172906115651131,
0.0003339536488056183,
-0.017516283318400383,
0.0068045021034777164,
0.0008705831132829189,
-0.0670081228017807,
0.0005691959522664547,
0.000002546701580286026,
0.007108851335942745,
-0.006914928555488586,
0.010640861466526985,
0.004063770174980164,
0.005386024713516235,
0.018933795392513275,
0.010685611516237259,
-0.0019588442519307137,
-0.00048089982010424137,
0.030683256685733795,
0.015345742926001549,
0.0009112770203500986,
-0.0036711920984089375,
-0.015735097229480743,
0.004499971866607666,
0.020184950903058052,
-0.00477343937382102,
0.0203210711479187,
-0.016965141519904137,
-0.029755733907222748,
-0.01459804642945528,
0.003169144969433546,
-0.001352996565401554,
-0.0393107533454895,
-0.00859625730663538,
-0.0062449281103909016,
0.0011755521409213543,
-0.011430016718804836,
-0.010310817509889603,
0.021016079932451248,
-0.022417914122343063,
0.013974001631140709,
-0.014402996748685837,
0.006874377839267254,
0.018184099346399307,
-0.007703052368015051,
0.00847899541258812,
0.008740179240703583,
-0.016691796481609344,
0.0333266481757164,
0.026456043124198914,
0.009063971228897572,
-0.007499395869672298,
0.00893890205770731,
-0.016056232154369354,
0.00446215458214283,
-0.0011132669169455767,
0.013459221459925175,
-0.002877420512959361,
-0.010605331510305405,
0.01147877611219883,
0.004541757050901651,
0.017852792516350746,
0.03917722776532173,
-0.004643659107387066,
0.03830379247665405,
0.0003256398194935173,
0.022079814225435257,
0.004474503919482231,
-0.005372513085603714,
0.0003772968193516135,
-0.0064538344740867615,
-0.007695983164012432,
-0.0018770755268633366,
-0.020157355815172195,
0.017143243923783302,
0.0038305968046188354,
-0.004342022351920605,
0.00791670847684145,
-0.013057580217719078,
-0.005685240030288696,
-0.025998525321483612,
0.0035955477505922318,
0.006903914734721184,
0.004462704062461853,
0.006249669007956982,
-0.009924962185323238,
0.007589676417410374,
0.02115911990404129,
-0.00020352366846054792,
-0.01056830957531929,
0.01979941315948963,
0.003848278895020485,
0.010841399431228638,
-0.01848967745900154,
-0.00830890703946352,
0.012483076192438602,
-0.023104436695575714,
-0.002560446970164776,
0.004154871683567762,
0.009875290095806122,
0.0019067353568971157,
0.020243993028998375,
0.012685483321547508,
0.019892560318112373,
0.00882652960717678,
0.028461351990699768,
-0.01571851409971714,
-0.002823514398187399,
0.0010017724707722664,
0.028382569551467896,
0.006548609584569931,
-0.009066056460142136,
-0.006628259550780058,
-0.032506413757801056,
0.0116826007142663,
0.01565002277493477,
-0.0038734234403818846,
-0.0024361619725823402,
0.006791659630835056,
-0.0062515041790902615,
0.0667445957660675,
-0.01526087149977684,
0.000586740905418992,
-0.0009586331434547901,
-0.0012468656059354544,
-0.002724298043176532,
0.0017747883684933186,
-0.004682844504714012,
0.001009262865409255,
0.010531943291425705,
-0.002609065268188715,
0.020356599241495132,
-0.010080118663609028,
0.015385257080197334,
-0.0009947740472853184,
-0.005414961837232113,
0.003919531125575304,
0.018512437120079994,
0.009319768287241459,
-0.00032879505306482315,
-0.019961021840572357,
0.042665328830480576,
0.009429335594177246,
0.0179120022803545,
0.0003307980950921774,
0.009593443013727665,
0.013374687172472477,
-0.011264938861131668,
-0.015742331743240356,
-0.03199344873428345,
0.0007262942381203175,
0.01405580434948206,
-0.02097655087709427,
-0.007285804953426123,
-0.004817149601876736,
-0.004074818454682827,
-0.00671570748090744,
0.007620666641741991,
-0.02452191710472107,
-0.012391088530421257,
-0.012080078944563866,
-0.0060068885795772076,
0.009597799740731716,
-0.027301356196403503,
0.00012550479732453823,
0.007718066684901714,
-0.016471490263938904,
0.0038669519126415253,
0.009660227224230766,
-0.0022775069810450077,
-0.004670028109103441,
-0.026675548404455185,
-0.006624320521950722,
-0.013189814053475857,
-0.029692359268665314,
0.023333195596933365,
0.004585732705891132,
0.013034777715802193,
-0.0023556435480713844,
0.011495614424347878,
-0.01260565035045147,
0.000642925500869751,
0.0024550084490329027,
0.020487865433096886,
0.0019747139886021614,
-0.0007647387683391571,
0.014657849445939064,
0.00827724114060402,
0.019022664055228233,
0.010758459568023682,
-0.007628525607287884,
0.00974950660020113,
0.0038289083167910576,
-0.023186344653367996,
-0.026608459651470184,
-0.005898295436054468,
-0.007737165316939354,
-0.00455388193950057,
-0.030340764671564102,
0.02220715582370758,
0.005634365603327751,
0.01954188570380211,
0.010781454853713512,
-0.02468458190560341,
0.0007555272895842791,
-0.0347728431224823,
0.014145984314382076,
-0.029814375564455986,
0.004768185783177614,
0.004185013473033905,
-0.010260012932121754,
0.00858105719089508,
-0.009659784846007824,
-0.007759660482406616,
-0.08144854754209518,
-0.010430995374917984,
0.019638344645500183,
-0.007824788801372051,
0.008651478216052055,
0.0029188720509409904,
0.004244939424097538,
-0.009269116446375847,
0.0030034827068448067,
0.006302577909082174,
0.0028527858667075634,
0.005049007013440132,
-0.0036404896527528763,
0.03700345754623413,
-0.02854963205754757,
-0.002224467694759369,
0.007454933598637581,
0.016871469095349312,
0.009539349004626274,
-0.03908462077379227,
-0.008601399138569832,
0.014642635360360146,
0.005161982029676437,
-0.013330521062016487,
0.015368307940661907,
0.027650218456983566,
0.009409124031662941,
-0.006888966541737318,
0.041346803307533264,
0.005727111361920834,
-0.014100017957389355,
-0.011547595262527466,
0.007341614458709955,
0.004662097431719303,
-0.02288300171494484,
0.006944706197828054,
-0.029523780569434166,
0.0041412608698010445,
0.0011164996540173888,
0.0342453233897686,
0.008404591120779514,
0.013846660032868385,
0.008376982063055038,
-0.003649070393294096,
0.0029823975637555122,
0.011629875749349594,
0.005504800472408533,
0.011043919250369072,
0.01582084596157074,
-0.01517748273909092,
0.016437843441963196,
-0.0018159666797146201,
0.011268114671111107,
0.013455348089337349,
-0.003033612621948123,
-0.01816398650407791,
-0.005379963666200638,
0.02799668163061142,
-0.008558101952075958,
-0.0006061885505914688,
-0.025156693533062935,
0.006954559590667486,
-0.007317995652556419,
-0.008248023688793182,
-0.001355186803266406,
0.010373973287642002,
0.01753239706158638,
-0.014015494845807552,
-0.004912746138870716,
0.010163369588553905,
0.007410615216940641,
-0.015619291923940182,
-0.009186342358589172,
-0.011739159002900124,
0.006489219609647989,
0.004842497408390045,
-0.011658012866973877,
-0.004764110315591097,
-0.013833782635629177,
-0.018714498728513718,
0.002745874924585223,
0.006347193382680416,
-0.02243484929203987,
0.026722867041826248,
-0.008466674946248531,
0.01631501503288746,
0.015305264852941036,
-0.0017607819754630327,
0.008238554000854492,
-0.01779051125049591,
0.010890103876590729,
0.025908512994647026,
-0.010268008336424828,
0.009987144730985165,
-0.03934592008590698,
0.012988481670618057,
0.00306587852537632,
-0.006323642563074827,
-0.004312146455049515,
0.00822155550122261,
0.0022560800425708294,
-0.008046219125390053,
-0.0012167381355538964,
-0.009607718326151371,
-0.039341941475868225,
0.015131986699998379,
0.013628699816763401,
-0.0044563645496964455,
-0.015103640034794807,
0.005707224830985069,
-0.00460817851126194,
0.0170535109937191,
-0.004936662036925554,
0.02064017951488495,
0.01596718281507492,
0.018588734790682793,
0.027652934193611145,
-0.006811578758060932,
0.07262447476387024,
0.010317370295524597,
-0.0014174855314195156,
-0.006603597197681665,
-0.00099913589656353,
-0.026266727596521378,
-0.039519693702459335,
-0.0009698134381324053,
0.03237329050898552,
0.003475286765024066,
0.010507510043680668,
-0.020341994240880013,
-0.014846976846456528,
0.012955373153090477,
0.0021545710042119026,
-0.005211086943745613,
-0.034191153943538666,
0.004526148084551096,
0.013038061559200287,
-0.0030862665735185146,
-0.011416005901992321,
-0.009630261920392513,
-0.0040824334137141705,
-0.007326880469918251,
0.007279139012098312,
0.011584769934415817,
-0.005540893413126469,
-0.01119418628513813,
-0.03083518147468567,
0.003915987443178892,
-0.013002620078623295,
-0.0046833897940814495,
-0.008534759283065796,
-0.0005670737591572106,
0.001885242760181427,
-0.0016159075312316418,
0.007309915032237768,
-0.01578085869550705,
0.01094026304781437,
-0.012515358626842499,
-0.006005933973938227,
-0.01481914333999157,
-0.00917964056134224,
0.001403524656780064,
-0.0343918576836586,
0.007637638598680496,
0.012016762048006058,
-0.009844581596553326,
-0.006406409665942192,
-0.016294345259666443,
-0.004775829613208771,
0.017788678407669067,
0.012899727560579777,
-0.001217978773638606,
0.004773260094225407,
0.014912368729710579,
-0.011249208822846413,
-0.007464016787707806,
0.015596980229020119,
0.023715604096651077,
0.0011809696443378925,
-0.0227340180426836,
-0.005634462460875511,
-0.022761955857276917,
-0.003186127170920372,
-0.0030716722831130028,
-0.0015615301672369242,
-0.006829604972153902,
-0.04672107473015785,
-0.006676989607512951,
-0.00009275326738134027,
0.011506442911922932,
-0.005491788033396006,
-0.01078735664486885,
-0.021761111915111542,
0.021260753273963928,
0.014749922789633274,
0.010552896186709404,
0.006792337633669376,
-0.026010550558567047,
-0.022662218660116196,
0.038196664303541183,
-0.009776094928383827,
-0.0017048388253897429,
0.031226495280861855,
0.004499956499785185,
-0.007992953062057495,
-0.07450224459171295,
-0.010094412602484226,
-0.023194344714283943,
-0.0028679349925369024,
-0.009054172784090042,
0.031257037073373795,
-0.006252107210457325,
0.015045716427266598,
-0.021574992686510086,
-0.013541247695684433,
-0.00936083123087883,
-0.02165159396827221,
0.00550752691924572,
-0.015301888808608055,
0.014420554973185062,
0.007686063647270203,
0.016171475872397423,
0.010635526850819588,
0.007998345419764519,
0.002551274374127388,
-0.0022762110456824303,
0.016235273331403732,
-0.021716909483075142,
0.005431105848401785,
-0.014498449862003326,
-0.08152909576892853,
-0.023460673168301582,
-0.0036452843341976404,
0.005708814598619938,
0.01747881807386875,
0.014311866834759712,
0.02609948441386223,
0.014980042353272438,
-0.01307807769626379,
-0.012299281544983387,
-0.012970196083188057,
-0.005652627442032099,
0.000081685371696949,
-0.02552461065351963,
0.00691205682232976,
-0.007899156771600246,
0.00970131903886795,
0.002720701275393367,
-0.01310140173882246,
-0.040857020765542984,
0.019934743642807007,
0.004032421857118607,
-0.002971310168504715,
-0.00942583940923214,
-0.003907141741365194,
-0.015091733075678349,
-0.02180365100502968,
0.01580420508980751,
0.015673348680138588,
-0.03152884542942047,
-0.008952739648520947,
-0.025879554450511932,
-0.011531030759215355,
0.02148715779185295,
0.012117616832256317,
-0.008785521611571312,
0.02386915683746338,
0.02262800559401512,
0.01557108759880066,
-0.008739795535802841,
-0.006252443417906761,
0.02178381197154522,
0.0025479632895439863,
-0.0131850466132164,
-0.0019399388693273067,
-0.006841108202934265,
0.007450918201357126,
-0.017817199230194092,
0.005772475618869066,
-0.022071415558457375,
0.005695297382771969,
0.017924629151821136,
0.013541467487812042,
-0.015612224116921425,
0.03148537874221802,
-0.011652993969619274,
-0.011147890239953995,
0.00041525019332766533,
0.00442230049520731,
0.00909522082656622,
-0.004889733158051968,
-0.0012888155179098248,
0.0014824150130152702,
0.0722433477640152,
-0.023324444890022278,
0.002295738086104393,
-0.0031798090785741806,
0.005569628439843655,
0.0010673339711502194,
0.006388536188751459,
0.00021236727479845285,
-0.02474624663591385,
0.002666328102350235,
0.015221071429550648,
-0.009063228033483028,
0.00035124877467751503,
0.008078880608081818,
0.01611468940973282,
-0.0037556602619588375,
0.009930519387125969,
0.007425959222018719,
-0.020464466884732246,
-0.030019257217645645,
-0.017241887748241425,
0.03195057809352875,
-0.03694750368595123,
0.02214302122592926,
0.015348092652857304,
0.006053757853806019,
0.006121678277850151,
0.0033684466034173965,
-0.011029795743525028,
0.01523473672568798,
-0.0017244608607143164,
0.0019042175263166428,
0.006476462818682194,
-0.007138797082006931,
0.017408020794391632,
0.029134608805179596,
0.0018295682966709137,
0.010397153906524181,
-0.0002316199243068695,
0.013988977298140526,
-0.0047713085077703,
0.02341252565383911,
0.006174851208925247,
0.003748257178813219,
0.012852583080530167,
-0.010062847286462784,
0.012149052694439888,
0.003923541866242886,
-0.004523206502199173,
0.0009986140066757798,
-0.04729999601840973,
0.0045717377215623856,
0.022248750552535057,
0.014139882288873196,
0.0010896464809775352,
-0.010845441371202469,
0.007822960615158081,
0.007967937737703323,
0.004083704669028521,
-0.0064805252477526665,
-0.0075738378800451756,
-0.008450820110738277,
0.008031902834773064,
-0.015640821307897568,
0.010932148434221745,
0.013112932443618774,
0.012983746826648712,
-0.012239090166985989,
-0.01209481991827488,
0.011541975662112236,
-0.007581966929137707,
0.011134825646877289,
0.009024526923894882,
-0.018299542367458344,
-0.001492554321885109,
0.006908319890499115,
0.008861210197210312,
0.014152199029922485,
-0.0007712487131357193,
0.010155905038118362,
-0.0035351323895156384,
-0.00007693469524383545,
0.02962883748114109,
-0.010833822190761566,
-0.009516232647001743,
-0.010966360569000244,
-0.006662769243121147,
-0.03167179226875305,
0.0025182717945426702,
0.005730528384447098,
0.01754099875688553,
0.012221220880746841,
0.00792836956679821,
0.0032491562888026237,
0.01362401433289051,
0.033090606331825256,
0.024151746183633804,
-0.0008572513470426202,
-0.005672052036970854,
0.006659106817096472,
0.013206654228270054,
-0.0014944649301469326,
-0.022050561383366585,
-0.0008233424741774797,
0.010391413234174252,
-0.0005189703078940511,
-0.010271505452692509,
0.02447865530848503,
-0.02591645158827305,
0.00005793571472167969,
-0.032362956553697586,
0.00023760367184877396,
0.005454374011605978,
-0.001368523109704256,
0.008832232095301151,
0.017872821539640427,
0.0015164039796218276,
-0.013380530290305614,
0.012345557101070881,
-0.011825437657535076,
-0.0035957403015345335,
0.008538611233234406,
0.005447503179311752,
0.0031143883243203163,
-0.005328505765646696,
-0.031985338777303696,
-0.0022911857813596725,
-0.02001028135418892,
-0.003769691102206707,
-0.002137488219887018,
0.02307811751961708,
-0.017643362283706665,
-0.0336410291492939,
-0.00240473635494709,
-0.01149928942322731,
-0.006056067533791065,
0.0018463092856109142,
0.007131190970540047,
0.008354626595973969,
0.012301173061132431,
0.015180743299424648,
-0.016919808462262154,
0.00899787899106741,
-0.02187405154109001,
0.01042716670781374,
0.0004980070516467094,
0.01844143122434616,
0.009650339372456074,
0.01631714589893818,
0.00053734565153718,
-0.005018867552280426,
-0.006014866288751364,
0.0070664845407009125,
-0.007555758114904165,
-0.0016795648261904716,
0.007822052575647831,
0.020326141268014908,
-0.00849919579923153,
-0.012948630377650261,
0.0008280538022518158,
-0.011586010456085205,
-0.010536471381783485,
-0.004574552644044161,
-0.005715729668736458,
0.0010392392287030816,
0.017190182581543922,
0.009742987342178822,
0.02707267366349697,
0.004872032906860113,
-0.006283444818109274,
0.03237215429544449,
0.011486606672406197,
0.004487309604883194,
0.01954498514533043,
-0.0029788766987621784,
-0.005085011012852192,
0.026067420840263367,
0.008008278906345367,
0.00278475577943027,
0.015494059771299362,
-0.006096882279962301,
0.0062744044698774815,
0.013740669935941696,
-0.012155447155237198,
-0.014747563749551773,
-0.006334565579891205,
-0.010665887966752052,
-0.0329691618680954,
-0.006993279326707125,
0.003759219776839018,
0.0022595433983951807,
-0.010740966536104679,
-0.013579769060015678,
-0.000736722256988287,
0.009237966500222683,
0.0028717927634716034,
-0.00002551451325416565,
-0.007816408760845661,
0.009986874647438526,
0.0030840234830975533,
0.025304429233074188,
-0.0019495096057653427
] | [
0.3039272725582123,
-0.10649710148572922,
-0.05302848294377327,
0.0979810357093811,
0.05543820559978485,
0.40008798241615295,
0.5217987895011902,
0.41894394159317017,
-0.49512261152267456,
-0.5274999737739563,
0.29631292819976807,
-0.334308385848999,
-0.09376875311136246,
0.2284785509109497,
-0.049735281616449356,
0.5326364040374756,
0.4764634072780609,
0.3831632733345032,
-0.308643639087677,
-0.0858006551861763,
-0.3765619993209839,
-0.6112303137779236,
0.5589925050735474,
0.45157960057258606,
-0.24359920620918274,
0.15817800164222717,
0.1569257229566574,
0.13157342374324799,
0.20033478736877441,
-0.16761718690395355,
-0.3897526264190674,
0.8338471055030823,
0.3005233407020569,
-0.31829237937927246,
0.2727680206298828,
-0.25634217262268066,
-0.1407671719789505,
0.09794524312019348,
0.057803090661764145,
-0.15723693370819092,
-0.08511419594287872,
-0.2447948306798935,
0.07495152205228806,
-0.18241210281848907,
-0.4182443916797638,
-0.258720338344574,
-0.8751126527786255,
0.6434239745140076,
-0.25540590286254883,
-0.06463044881820679,
0.2267390489578247,
0.13753777742385864,
0.2164807915687561,
0.06453286111354828,
-0.21954932808876038,
-0.011442492716014385,
-0.5013467073440552,
-0.0802476704120636,
0.3339928090572357,
-0.1585405319929123,
0.06678324937820435,
-0.31090477108955383,
-0.5593842267990112,
0.14408603310585022,
-0.3420281708240509,
0.45030492544174194,
-0.08816631883382797,
0.41292986273765564,
0.15126892924308777,
0.14343595504760742,
-0.0586632676422596,
-0.39004677534103394,
-0.04196407273411751,
0.07503080368041992,
0.09281159937381744,
0.10285796970129013,
-0.06638913601636887,
-0.18013595044612885,
-0.11146434396505356,
-0.0537971630692482,
-0.30924665927886963,
-0.39454326033592224,
0.5512270927429199,
-0.482797235250473,
0.7495672106742859,
-0.1438826471567154,
-0.30608054995536804,
0.46457457542419434,
-0.00517061073333025,
0.07157502323389053,
0.15884752571582794,
0.005302156321704388,
0.8202805519104004,
0.3876565396785736,
-0.48911142349243164,
0.4280286729335785,
0.04727911576628685,
-0.11269696801900864,
0.4415316581726074,
-0.2984081506729126,
-0.552394449710846,
0.06121576204895973,
0.2642160654067993,
0.24801363050937653,
-0.02287246659398079,
0.1402186155319214,
0.0378219336271286,
0.020600972697138786,
-0.2918223738670349,
0.0886906310915947,
-0.16014890372753143,
0.21819165349006653,
-0.2319413423538208,
-0.25286704301834106,
-0.19583085179328918,
0.20687824487686157,
0.4076509475708008,
-0.5951270461082458,
0.04287464916706085,
-0.19666428864002228,
-0.44934016466140747,
0.6001201272010803,
-0.17939721047878265,
0.2077585607767105,
-0.2349143624305725,
0.2262028455734253,
0.384335994720459,
0.16759493947029114,
0.24375519156455994,
0.31750166416168213,
-0.1374872773885727,
0.6507083773612976,
-0.14860159158706665,
0.08405423164367676,
0.3305804431438446,
-0.2673094570636749,
-0.25797364115715027,
0.44733184576034546,
0.1692330688238144,
0.02242688089609146,
-0.4193551242351532,
-0.40272125601768494,
-0.25269192457199097,
0.1978835165500641,
-0.23403893411159515,
-0.3712846040725708,
-0.08675405383110046,
-0.22514350712299347,
0.048697952181100845,
-0.06690125167369843,
0.18073458969593048,
0.15280239284038544,
-0.3984719514846802,
-0.3966679573059082,
-0.0126764215528965,
0.12445207685232162,
-0.5472091436386108,
-0.19693563878536224,
0.17498096823692322,
0.13088735938072205,
0.3697371780872345,
0.3205033838748932,
-0.3800799548625946,
-0.11772400140762329,
0.6482061147689819,
-0.07061471790075302,
-0.049621324986219406,
-0.07026571035385132,
-0.09324491024017334,
0.22767886519432068,
-0.1930212676525116,
-0.00760293286293745,
0.02183244563639164,
-0.4633329212665558,
-0.06062614917755127,
0.35357582569122314,
0.3091348707675934,
-0.081865094602108,
0.2684032917022705,
0.29746076464653015,
-0.42916128039360046,
-0.17314842343330383,
-0.09390304237604141,
-0.434207022190094,
0.16211631894111633,
-0.11698739975690842,
0.41207459568977356,
0.14720721542835236,
0.1507115215063095,
-0.3272077143192291,
-0.12613266706466675,
-0.5246837735176086,
0.6607528328895569,
-0.5118537545204163,
0.930061399936676,
-0.12234782427549362,
-0.17126744985580444,
1.145031452178955,
0.5668244957923889,
-0.02211383357644081,
-0.14976681768894196,
-0.13733069598674774,
0.6978998184204102,
-0.29244422912597656,
-0.7774229645729065,
0.08310629427433014,
-0.057222455739974976,
-0.4612112045288086,
0.1384407877922058,
-0.33363261818885803,
0.16390521824359894,
-0.48524391651153564,
-0.07638059556484222,
0.10653691738843918,
0.031873758882284164,
-0.020488915964961052,
-0.40832585096359253,
-0.28193557262420654,
0.22701434791088104,
-0.4154423773288727,
0.34970173239707947,
-0.663017213344574,
0.5372146964073181,
0.38694384694099426,
-0.12688452005386353,
0.4418020248413086,
0.7464505434036255,
-0.08667704463005066,
0.8891597390174866,
-1.0135051012039185,
0.2244528979063034,
-0.012953506782650948,
0.1988757848739624,
-0.7951198220252991,
-0.14881213009357452,
0.46431732177734375,
0.14835405349731445,
-0.300460547208786,
0.17933157086372375,
0.21561138331890106,
0.2036115825176239,
0.15613953769207,
-0.3635949492454529,
0.11229799687862396,
0.17138716578483582,
-0.42030587792396545,
-0.06092562898993492,
0.34360483288764954,
-0.655377984046936,
0.09588274359703064,
0.17073096334934235,
0.5269584059715271,
0.045630112290382385,
-0.3768187165260315,
-0.02645895816385746,
0.2593501806259155,
0.17192965745925903,
-0.4945676326751709,
0.34240326285362244,
-0.2533333897590637,
-0.2322765439748764,
0.3761167824268341,
0.11968105286359787,
0.0340728759765625,
0.15478971600532532,
-0.4454323947429657,
-0.9657910466194153,
-0.6575596928596497,
0.7252665758132935,
0.29702094197273254,
0.7080975770950317,
-0.015921786427497864,
-0.39103129506111145,
0.17670786380767822,
0.20752662420272827,
-0.618284285068512,
0.013430454768240452,
0.7700124382972717,
-0.6299335956573486,
-0.42163124680519104,
-0.45277100801467896,
0.20241405069828033,
0.6133371591567993,
-0.34102365374565125,
0.026946336030960083,
-0.6968858242034912,
0.04972796514630318,
0.12664580345153809,
-0.5246015191078186,
-0.2672708034515381,
-0.06821148842573166,
0.34735628962516785,
0.023791447281837463,
0.3826962113380432,
0.29971179366111755,
0.5743458867073059,
0.1669466197490692,
0.0686146691441536,
0.7846582531929016,
-0.42894846200942993,
-0.10763789713382721,
-0.04210420325398445,
-0.30297064781188965,
-0.07207052409648895,
-0.2166823446750641,
0.0855436697602272,
-0.445439875125885,
-0.47023606300354004,
-6.197333812713623,
0.3145103454589844,
-0.4488254189491272,
-0.38068777322769165,
-0.3143513798713684,
0.20491470396518707,
1.1687827110290527,
0.24014726281166077,
0.3583085834980011,
0.4190390706062317,
0.6610747575759888,
0.3102700114250183,
0.1822412610054016,
0.2190818339586258,
0.23685234785079956,
-0.032610367983579636,
0.2977087199687958,
-0.5704990029335022,
0.10827036201953888,
0.0018001495627686381,
-0.03275376930832863,
0.18010689318180084,
0.2933475375175476,
0.16731181740760803,
0.4663470387458801,
0.6243008971214294,
-1.0157831907272339,
0.36935919523239136,
-0.0012164158979430795,
-0.23327447474002838,
0.2771477997303009,
-0.7444738149642944,
-0.06328992545604706,
-0.1898631751537323,
-0.13118495047092438,
-0.08599980920553207,
-0.07427333295345306,
0.10208602994680405,
-0.16561630368232727,
-0.13150136172771454,
0.026751108467578888,
0.02042054384946823,
-0.3452746272087097,
-0.02994266338646412,
0.12987712025642395,
0.10664432495832443,
0.29923462867736816,
-0.227937713265419,
-0.03505809232592583,
0.7059223651885986,
0.0895821750164032,
0.056874629110097885,
0.2501024007797241,
0.8263582587242126,
0.16048423945903778,
-0.20260116457939148,
0.15634271502494812,
0.6018016934394836,
-0.4423138201236725,
0.2523006200790405,
-0.015007510781288147,
-0.2940434217453003,
0.18164634704589844,
-0.35553017258644104,
0.22268924117088318,
0.18501034379005432,
-0.9108944535255432,
0.05504367873072624,
0.11440179497003555,
-0.011202135123312473,
0.021368805319070816,
-0.21935218572616577,
0.13337089121341705,
-0.8555693030357361,
0.014248340390622616,
-0.45591792464256287,
0.11923465132713318,
-0.10886992514133453,
0.05336807295680046,
-0.30399009585380554,
0.03552689775824547,
0.031850557774305344,
0.07274071872234344,
-0.028907764703035355,
-0.03761845827102661,
0.18007470667362213,
-0.004308424424380064,
-0.14684489369392395,
-0.31829598546028137,
-0.10812126100063324,
0.42480891942977905,
-0.2238934338092804,
0.24316023290157318,
0.08911852538585663,
0.4637325406074524,
0.8500812649726868,
0.29344141483306885,
-0.10071468353271484,
0.19595062732696533,
-0.09901141375303268,
0.7829875946044922,
-0.25805729627609253,
-0.3317364454269409,
-1.1007122993469238,
-0.07090357691049576,
-0.1022682636976242,
-0.390906423330307,
0.1443442851305008,
0.49578776955604553,
-0.6565929055213928,
0.025482455268502235,
0.22413073480129242,
-0.5379846096038818,
-0.4615297317504883,
0.5673747658729553,
-0.2861020863056183,
0.02000913955271244,
-0.0015474512474611402,
0.6164942979812622,
-0.17471551895141602,
0.5070489048957825,
0.3667634427547455,
-0.10641247034072876,
0.6333065032958984,
-0.29188570380210876,
-0.3484685719013214,
0.3160720765590668,
0.3674013316631317,
-0.4421536922454834,
-0.15293292701244354,
-0.0732872411608696,
0.4551488161087036,
-0.09665525704622269,
0.025319039821624756,
-0.07643280923366547,
0.15793001651763916,
-0.3656196892261505,
-0.11839494854211807,
0.27800241112709045,
0.06862499564886093,
0.09210342168807983,
-0.0007575521012768149,
-0.1866217851638794,
0.5464457273483276,
-0.03484673798084259,
0.12167118489742279,
-0.21201439201831818,
-0.3829486072063446,
-0.09707209467887878,
-0.37594133615493774,
-0.01364693883806467,
0.10666686296463013,
0.10442639887332916,
0.12946411967277527,
-0.49132204055786133,
0.056392621248960495,
0.3024812638759613,
0.129298135638237,
0.15782947838306427,
-0.3559361398220062,
0.6214086413383484,
-0.10851146280765533,
-1.0458368062973022,
-0.09887247532606125,
-0.07503172010183334,
-0.44656506180763245,
0.3565855920314789,
-0.37363511323928833,
-0.10848904401063919,
0.38163840770721436,
-0.13105042278766632,
-0.3828953802585602,
0.2254008650779724,
0.10266043245792389,
0.12188515067100525,
-0.045907020568847656,
-0.3223615884780884,
0.0023339176550507545,
-0.15700837969779968,
0.24802687764167786,
0.22811125218868256,
0.09889435768127441,
-0.5758646130561829,
0.6309345960617065,
0.7257384657859802,
0.4050028622150421,
0.03531260788440704,
-0.09953232109546661,
-0.08555129915475845,
0.0584852509200573,
0.3369637429714203,
-0.41156628727912903,
0.1551210582256317,
-0.011066418141126633,
0.09907699376344681,
-0.08716513961553574,
0.5762574672698975,
0.18832433223724365,
-0.74156653881073,
0.05170281603932381,
-0.21994362771511078,
0.11092308908700943,
-0.15429529547691345,
0.05726218223571777,
0.32421454787254333,
-0.13896137475967407,
-0.13231754302978516,
-0.11775534600019455,
-0.46419933438301086,
-0.5811943411827087,
-0.026700694113969803,
-0.04719915613532066,
-0.30198100209236145,
0.28671932220458984,
-0.11926174908876419,
0.14277581870555878,
0.1972772777080536,
-0.09080559015274048,
0.06268305331468582,
0.08401137590408325,
0.06641055643558502,
0.4710664451122284,
0.029234474524855614,
-0.4059229791164398,
-0.22598394751548767,
0.2534199655056,
0.46488308906555176,
-1.0115522146224976,
-0.27157455682754517,
0.07359561324119568,
-0.49075818061828613,
-0.12970975041389465,
0.15191663801670074,
-0.11594954878091812,
-0.8912677764892578,
-0.07385052740573883,
0.08843909204006195,
-0.26105037331581116,
-0.0293305404484272,
0.8187581896781921,
0.024892497807741165,
0.36168256402015686,
0.03200388327240944,
-0.4220971167087555,
0.10472358018159866,
0.1461704820394516,
0.28643855452537537,
-0.22220750153064728,
-0.3029157221317291,
0.450142502784729,
0.15209221839904785,
-0.19454745948314667,
0.24536828696727753,
0.06099880486726761,
0.5832651257514954,
-0.23239484429359436,
0.09702520817518234,
-0.3274846374988556,
0.26669827103614807,
0.024361377581954002,
-0.47144216299057007,
-0.4216710329055786,
0.21747750043869019,
-0.018962997943162918,
-0.18205375969409943,
-0.1667899638414383,
-0.15999296307563782,
-0.2933303713798523,
0.39366960525512695,
-0.5700308680534363,
-0.0075459727086126804,
0.13690592348575592,
0.4600749611854553,
0.49107420444488525,
0.05226627364754677,
0.11269751936197281,
-0.4191516637802124,
0.17696994543075562,
-0.3830130994319916,
0.2286261022090912,
-0.6477382183074951,
-0.8577588200569153,
-0.19068315625190735,
-0.0577385351061821,
-0.05435919016599655,
-0.1341203898191452,
0.14477716386318207,
0.14019383490085602,
-0.27780047059059143,
-0.41656675934791565,
-0.18384571373462677,
-0.14915280044078827,
-0.34472814202308655,
-0.6183469295501709,
-0.10065741091966629,
-0.08033587038516998,
0.08805765211582184,
0.6505333781242371,
-0.19773948192596436,
-0.3190772831439972,
-0.9020226001739502,
0.3442747890949249,
0.21867625415325165,
-0.41738295555114746,
-0.0017898333026096225,
-0.07224343717098236,
0.21323664486408234,
0.06660477072000504,
-0.08427303284406662,
-0.17143182456493378,
0.5518444180488586,
0.12531477212905884,
0.2870274782180786,
0.5269678235054016,
-0.7038351893424988,
0.2928459942340851,
-0.15978460013866425,
-0.3194567561149597,
0.5966449975967407,
-0.01968487538397312,
-0.0035914655309170485,
0.45213091373443604,
0.6301445364952087,
0.07567824423313141,
-0.011528782546520233,
0.8197728395462036,
-0.19691148400306702,
0.3205670714378357,
0.0006561082554981112,
0.35096651315689087,
0.27830517292022705,
0.5030909776687622,
-0.6877661943435669,
0.28695425391197205,
-0.03655151277780533,
0.4036075174808502,
0.0449148491024971,
-0.6424005031585693,
-0.4500484764575958,
-0.19608649611473083,
0.9016276597976685,
0.4358835518360138,
0.016457680612802505,
-0.13504312932491302,
-0.04409253969788551,
-0.01484356913715601,
0.02158890850841999,
-0.032104894518852234,
0.3179375231266022,
-0.16443197429180145,
0.043121013790369034,
-0.29049015045166016,
-0.04081720858812332,
0.4526779353618622,
-0.2029436230659485,
-0.03031245619058609,
-0.11900242418050766,
-0.16711434721946716,
-0.42036911845207214,
0.06497576832771301,
-0.020418519154191017,
0.025133712217211723,
-0.5731123685836792,
0.23633332550525665,
-0.40331336855888367,
-0.5106166005134583,
0.5702850222587585,
0.13592976331710815,
-0.1739223450422287,
-0.038317158818244934,
0.040940508246421814,
-0.14180229604244232,
-0.4291577637195587,
0.31854015588760376,
0.41999298334121704,
-0.28003835678100586,
0.20569485425949097,
0.06477829813957214,
0.018191246315836906,
0.2958114743232727,
-0.5164187550544739,
0.08979267627000809,
-0.1383674144744873,
-0.21004217863082886,
0.3333689570426941,
0.04513566568493843,
-0.2822735905647278,
0.10698104649782181,
-0.06717298179864883,
-0.15808621048927307,
-0.0835360735654831,
-0.5215330123901367,
-0.36362752318382263,
0.40176308155059814,
0.06591016054153442,
-0.06068863347172737,
-0.20149613916873932,
0.0029796543531119823,
0.3039938509464264,
0.49189096689224243,
0.14645090699195862,
-0.4923667907714844,
-0.2300390750169754,
0.2091374546289444,
-0.4617260992527008,
0.8697290420532227,
-0.03850279748439789,
-0.2964990735054016,
-0.5192619562149048,
0.2888987064361572,
0.39153942465782166,
0.500537097454071,
-0.28733333945274353,
0.07354575395584106,
-0.0813979059457779,
0.008114569820463657,
0.556903600692749,
-0.33668115735054016,
-0.6084295511245728,
-0.5025717616081238,
-0.3077259361743927,
-0.6869425773620605,
0.7740315794944763,
0.14058713614940643,
0.1876981258392334,
-0.15144455432891846,
0.235253244638443,
0.38112205266952515,
-0.0793890506029129,
0.7295639514923096,
-0.3858683705329895,
-0.21190446615219116,
-0.4781077206134796,
0.5573117136955261,
-0.10496709495782852,
0.4410051107406616,
-0.0446900874376297,
0.24052616953849792,
0.455357164144516,
-0.3037997782230377,
0.4017350971698761,
-0.38087332248687744,
-0.34323012828826904,
-0.033635322004556656,
0.25158703327178955,
0.8974817991256714,
-0.13065990805625916,
-0.2303328812122345,
-0.6644622087478638,
0.2676282227039337,
-0.3525630831718445,
-0.32561546564102173,
-0.24763336777687073,
0.2307615727186203,
-0.04359406605362892,
-0.14281946420669556,
0.0070268623530864716,
-0.1157066822052002,
-0.18585406243801117,
-0.13898195326328278
] |
BACKGROUND: Recent studies have suggested that autophagy is utilized by cells as a protective mechanism against Listeria monocytogenes infection. METHODOLOGY/PRINCIPAL FINDINGS: However we find autophagy has no measurable role in vacuolar escape and intracellular growth in primary cultured bone marrow derived macrophages (BMDMs) deficient for autophagy (atg5(−/−)). Nevertheless, we provide evidence that the pore forming activity of the cholesterol-dependent cytolysin listeriolysin O (LLO) can induce autophagy subsequent to infection by L. monocytogenes. Infection of BMDMs with L. monocytogenes induced microtubule-associated protein light chain 3 (LC3) lipidation, consistent with autophagy activation, whereas a mutant lacking LLO did not. Infection of BMDMs that express LC3-GFP demonstrated that wild-type L. monocytogenes was encapsulated by LC3-GFP, consistent with autophagy activation, whereas a mutant lacking LLO was not. Bacillus subtilis expressing either LLO or a related cytolysin, perfringolysin O (PFO), induced LC3 colocalization and LC3 lipidation. Further, LLO-containing liposomes also recruited LC3-GFP, indicating that LLO was sufficient to induce targeted autophagy in the absence of infection. The role of autophagy had variable effects depending on the cell type assayed. In atg5(−/−) mouse embryonic fibroblasts, L. monocytogenes had a primary vacuole escape defect. However, the bacteria escaped and grew normally in atg5(−/−) BMDMs. CONCLUSIONS/SIGNIFICANCE: We propose that membrane damage, such as that caused by LLO, triggers bacterial-targeted autophagy, although autophagy does not affect the fate of wild-type intracellular L. monocytogenes in primary BMDMs. | [
-0.0077083297073841095,
0.009464512579143047,
-0.0008937506936490536,
0.0047804671339690685,
0.008947580121457577,
-0.02018631063401699,
0.008712111040949821,
0.0004267685580998659,
-0.013086197897791862,
-0.008071176707744598,
-0.020434431731700897,
0.006596417631953955,
-0.006146244704723358,
0.033861421048641205,
-0.02559085749089718,
0.011545618996024132,
-0.02590758539736271,
0.000028268899768590927,
0.0065102954395115376,
0.01184541080147028,
0.004996362142264843,
-0.01893365941941738,
0.010680091567337513,
-0.02224474586546421,
0.0004870900884270668,
0.017992552369832993,
-0.0010402156040072441,
-0.025441471487283707,
0.010097924619913101,
0.005208865273743868,
0.006729543209075928,
-0.00923236459493637,
-0.002024313434958458,
-0.017640484496951103,
0.016644654795527458,
0.018512580543756485,
0.005938638933002949,
0.02210192196071148,
0.01608908921480179,
-0.003763999789953232,
0.02774905040860176,
-0.005454624071717262,
0.00145843462087214,
-0.012137668207287788,
-0.010431088507175446,
-0.0242944173514843,
0.0063027008436620235,
-0.0034743945579975843,
-0.007514881901443005,
0.008977155201137066,
-0.011462660506367683,
-0.019250957295298576,
-0.005525337532162666,
-0.015366624109447002,
-0.006083888001739979,
0.007366001605987549,
0.019885525107383728,
-0.010969573631882668,
-0.014423814602196217,
0.011383887380361557,
0.002562399487942457,
-0.013560621067881584,
0.0021694963797926903,
-0.0055408054031431675,
-0.028604965656995773,
-0.06683695316314697,
-0.023277558386325836,
0.013113640248775482,
-0.004203226417303085,
-0.0040786387398839,
-0.003393664490431547,
0.007081890478730202,
-0.0035519753582775593,
0.006782002747058868,
0.02679520472884178,
-0.0120781771838665,
-0.0022223738487809896,
0.03289150074124336,
0.016248498111963272,
0.0019768383353948593,
-0.0041793822310864925,
-0.018226703628897667,
-0.012773388996720314,
0.0077275559306144714,
-0.00047988398000597954,
0.019165106117725372,
-0.02040722966194153,
0.0014071767218410969,
-0.007149531506001949,
0.019835390150547028,
0.01128300093114376,
0.02598721906542778,
-0.003481099847704172,
-0.003712113481014967,
0.023147955536842346,
-0.01247402559965849,
-0.008950550109148026,
-0.001682221656665206,
-0.01800565980374813,
-0.008339866064488888,
-0.005224863067269325,
0.007171423174440861,
0.014239534735679626,
-0.011500399559736252,
-0.005279386416077614,
0.006048595067113638,
-0.0021920809522271156,
0.0010038507170975208,
0.038355547934770584,
0.012087510898709297,
0.0048334538005292416,
-0.014455152675509453,
-0.016458459198474884,
-0.005879437550902367,
-0.007301408797502518,
0.002525083487853408,
-0.014358319342136383,
0.008595023304224014,
0.015259364619851112,
-0.0007979872170835733,
0.01401375699788332,
-0.02559935301542282,
0.006197893992066383,
0.001228261273354292,
0.0018740056548267603,
0.0010551554150879383,
0.006295907311141491,
0.0024297735653817654,
0.006251981481909752,
0.0006231046281754971,
-0.008052785880863667,
-0.002881712047383189,
0.0060905832797288895,
0.01153385266661644,
0.009949409402906895,
0.007567557971924543,
-0.016115840524435043,
-0.030086643993854523,
0.009476550854742527,
-0.012113278731703758,
-0.006441801320761442,
0.010498994030058384,
-0.0009931401582434773,
0.011279440484941006,
0.012477921321988106,
0.003888885024935007,
-0.025842582806944847,
-0.0005411147139966488,
0.0148072624579072,
-0.00802101381123066,
0.006715675815939903,
0.007054574321955442,
-0.0033335634507238865,
-0.014262260869145393,
-0.001734814839437604,
-0.004358336795121431,
-0.004275137558579445,
-0.01176154799759388,
-0.009454363025724888,
-0.0023044412955641747,
-0.013167422264814377,
-0.00854247435927391,
0.02125515416264534,
0.009091442450881004,
-0.011144689284265041,
0.005690806545317173,
-0.005240709986537695,
-0.012256000190973282,
-0.000031170202419161797,
0.0008081578416749835,
-0.013788700103759766,
0.00803716666996479,
0.012304918840527534,
0.0039643580093979836,
0.003037411952391267,
0.009984036907553673,
-0.01204593200236559,
0.009614437818527222,
-0.011471070349216461,
0.06634023040533066,
0.015261175110936165,
0.013100294396281242,
-0.002951219445094466,
0.027814194560050964,
0.01630135253071785,
-0.013278859667479992,
0.016936998814344406,
-0.007737209089100361,
-0.0017237452557310462,
-0.029181580990552902,
-0.00020057708024978638,
0.013136123307049274,
-0.004272371530532837,
0.008547576144337654,
-0.033399712294340134,
0.003032942768186331,
-0.003584335558116436,
-0.0018832205096259713,
0.010291337966918945,
-0.01991693675518036,
0.02500421181321144,
-0.016866199672222137,
0.017011990770697594,
-0.009455316700041294,
-0.008074630983173847,
-0.010708890855312347,
-0.014659841544926167,
-0.0019397790310904384,
-0.023202985525131226,
0.005666418932378292,
0.01029440388083458,
-0.0019963127560913563,
-0.011739118956029415,
-0.0010218723909929395,
-0.012995262630283833,
-0.00013687275350093842,
-0.00608289847150445,
-0.019709760323166847,
-0.004960121586918831,
-0.01187077909708023,
-0.0033811540342867374,
0.026610905304551125,
0.020444277673959732,
-0.015476934611797333,
-0.009529057890176773,
0.006406837143003941,
-0.014638528227806091,
0.011412186548113823,
-0.0011290241964161396,
0.0025548390112817287,
-0.00383485434576869,
0.0034589136485010386,
-0.009976204484701157,
-0.005591380875557661,
0.018367156386375427,
0.00242429506033659,
0.008874237537384033,
0.010135188698768616,
0.024326851591467857,
-0.01325974427163601,
-0.0007063967641443014,
-0.0036660514306277037,
0.01800285466015339,
-0.007020590361207724,
0.022579146549105644,
-0.007646843791007996,
-0.01449253037571907,
0.01739877089858055,
-0.0045285942032933235,
-0.02169974148273468,
0.0054110996425151825,
-0.0005308003164827824,
0.010530102998018265,
-0.011110268533229828,
0.01092037744820118,
-0.020434172824025154,
0.027579007670283318,
-0.014981432817876339,
0.025572948157787323,
0.004380872473120689,
-0.0022884297650307417,
0.003072321182116866,
-0.01448367815464735,
-0.010138798505067825,
0.013731885701417923,
0.02065187692642212,
0.012318698689341545,
-0.0020972799975425005,
-0.009052450768649578,
0.001051031518727541,
0.007803300395607948,
-0.004234311170876026,
-0.0033245054073631763,
-0.0812794491648674,
-0.017594318836927414,
-0.009831623174250126,
-0.019067134708166122,
0.003573340130969882,
0.004856374580413103,
0.007509540766477585,
0.004003915004432201,
-0.010158681310713291,
-0.02404768019914627,
-0.007769495248794556,
0.0272388719022274,
-0.00024655426386743784,
-0.017451006919145584,
0.007918192073702812,
-0.007831462658941746,
0.011891539208590984,
0.007503977045416832,
-0.004078868310898542,
0.010738051496446133,
0.014616267755627632,
0.0007007294334471226,
0.022526344284415245,
-0.00586008932441473,
0.005345597863197327,
-0.006089294794946909,
0.014018431305885315,
0.006280773319303989,
0.002882380736991763,
0.01072834711521864,
0.0022341636940836906,
0.013405762612819672,
0.006319570355117321,
0.017286501824855804,
0.017801601439714432,
0.021874351426959038,
0.010640602558851242,
-0.0005714255385100842,
-0.010129986330866814,
0.03015017881989479,
0.001851673237979412,
0.007400503382086754,
-0.0031727757304906845,
0.004308583214879036,
0.02076980657875538,
0.007501915097236633,
-0.010196461342275143,
0.007894763723015785,
0.011826317757368088,
-0.0066350302658975124,
-0.010913418605923653,
0.000265333685092628,
0.009956391528248787,
0.025760872289538383,
-0.009021583944559097,
0.01074807159602642,
-0.017677364870905876,
0.006689589936286211,
-0.018323834985494614,
0.0003145435475744307,
-0.0072665102779865265,
-0.04864814132452011,
0.015298238024115562,
0.023261653259396553,
-0.034582898020744324,
0.025155428797006607,
0.012568196281790733,
0.023981403559446335,
-0.00021839357214048505,
0.0037533293943852186,
0.006840797606855631,
0.0008263732306659222,
0.014689229428768158,
-0.007604425773024559,
-0.0031571087893098593,
-0.011720947921276093,
-0.008633194491267204,
-0.000022150808945298195,
-0.006158178672194481,
0.005861509591341019,
0.002399309305474162,
0.004810602404177189,
-0.013329173438251019,
-0.0013174311025068164,
-0.009799333289265633,
-0.022830665111541748,
0.007852882146835327,
0.029651161283254623,
0.008721699938178062,
-0.011323071084916592,
-0.016538336873054504,
0.007987271063029766,
-0.017372991889715195,
0.007032118272036314,
0.00918157771229744,
-0.00845663994550705,
0.00477345148101449,
0.00302896648645401,
-0.002222364768385887,
0.007303959224373102,
-0.02180492877960205,
0.009156462736427784,
-0.008173179812729359,
-0.01522220391780138,
-0.02616751939058304,
0.014898901805281639,
-0.00532042421400547,
0.024331729859113693,
-0.004194323904812336,
-0.007465192582458258,
-0.0019115374889224768,
-0.002241827081888914,
-0.00914077740162611,
0.026237355545163155,
0.0036414742935448885,
0.015754805877804756,
-0.00720256008207798,
-0.01733168214559555,
0.07250635325908661,
-0.018129674717783928,
-0.0020360813941806555,
-0.00924635585397482,
-0.005017101764678955,
-0.03148604929447174,
-0.04424804076552391,
0.011679112911224365,
0.02258036658167839,
0.001942252740263939,
0.012405658140778542,
-0.0009578368626534939,
0.008718649856746197,
0.0012599378824234009,
-0.011674041859805584,
0.016965676099061966,
0.009368727914988995,
-0.011075426824390888,
0.008336516097187996,
-0.015258795581758022,
-0.0059511130675673485,
-0.011112787760794163,
-0.002113543450832367,
-0.013497434556484222,
0.005603620782494545,
-0.016651537269353867,
-0.01126149669289589,
-0.012376101687550545,
-0.019362442195415497,
-0.00010528217535465956,
0.010812598280608654,
0.01596764475107193,
-0.0015130365500226617,
0.006746386177837849,
0.013750800862908363,
0.013924350962042809,
-0.004930293187499046,
-0.013943387195467949,
0.0006402024300768971,
0.0020976304076611996,
-0.013646245002746582,
-0.01264231838285923,
0.03399070352315903,
0.013573836535215378,
-0.01918639801442623,
-0.0049994089640676975,
0.0022855899296700954,
-0.00644140038639307,
0.00010273116640746593,
-0.010424820706248283,
-0.009164868853986263,
0.00357712060213089,
0.007641184143722057,
0.0023800907656550407,
-0.0015580158215016127,
-0.01190548948943615,
0.019112098962068558,
-0.0023054671473801136,
-0.012258919887244701,
-0.014479478821158409,
-0.01813138835132122,
0.03752799704670906,
0.01707644760608673,
0.003667652839794755,
0.012189868837594986,
-0.013487149961292744,
-0.009924574755132198,
0.0005624002078548074,
-0.0027115759439766407,
-0.015894120559096336,
0.02027931809425354,
-0.02443464659154415,
-0.025817112997174263,
0.0006855038227513433,
-0.019297318533062935,
-0.03584849461913109,
-0.0045748744159936905,
-0.026089908555150032,
0.025909962132573128,
0.0022634495981037617,
-0.0010543749667704105,
0.026394017040729523,
-0.016358625143766403,
-0.0012978983577340841,
0.02023700624704361,
-0.004124116152524948,
-0.015354827046394348,
-0.0751931220293045,
-0.014955878257751465,
-0.022864513099193573,
-0.0024120525922626257,
0.0037948412355035543,
0.0074319988489151,
-0.024166177958250046,
-0.006696714088320732,
0.020044289529323578,
-0.006075896322727203,
-0.0035614101216197014,
0.014992455020546913,
-0.02686321921646595,
0.013861360028386116,
0.01309347152709961,
-0.004376617260277271,
-0.018734341487288475,
-0.0010781869059428573,
-0.024733636528253555,
0.0036758596543222666,
0.002051105722784996,
0.004637368489056826,
-0.01351899839937687,
-0.003927792888134718,
0.0010305991163477302,
-0.08123952150344849,
0.013738192617893219,
0.013260265812277794,
-0.0046230219304561615,
-0.0024862943682819605,
-0.0032932348549365997,
-0.005519727244973183,
-0.01146034337580204,
0.01811862364411354,
-0.016908884048461914,
0.009630848653614521,
-0.021332094445824623,
0.0034849923104047775,
-0.021942943334579468,
-0.00991298258304596,
-0.0017241865862160921,
0.01840425468981266,
-0.028471387922763824,
-0.011587518267333508,
-0.0064895180985331535,
0.008359508588910103,
0.01067227404564619,
-0.008641552180051804,
0.0015669823624193668,
-0.009626747108995914,
-0.021188832819461823,
-0.001937852706760168,
0.005817594472318888,
0.0029738768935203552,
0.004038390703499317,
0.0033498406410217285,
0.009797323495149612,
-0.01283960323780775,
-0.0005523525178432465,
-0.001382911577820778,
-0.013831840828061104,
-0.012073257938027382,
0.00492264935746789,
-0.001996817300096154,
-0.012012271210551262,
-0.0015335783828049898,
0.00881350040435791,
-0.00792763289064169,
0.005249083042144775,
-0.0063045877031981945,
0.005252601113170385,
0.003393396968021989,
-0.0035623202566057444,
0.016618575900793076,
-0.02471744641661644,
0.004349851980805397,
-0.01917525939643383,
0.012158277444541454,
-0.009028050117194653,
-0.004382023122161627,
0.01541740819811821,
-0.006885085720568895,
-0.006968217436224222,
-0.010111585259437561,
0.00961238145828247,
-0.00440986780449748,
0.029028713703155518,
-0.005831444635987282,
0.07112953066825867,
0.0010378016158938408,
-0.002776642795652151,
-0.013585707172751427,
-0.0022133435122668743,
0.001946264412254095,
-0.0034192311577498913,
-0.004073947202414274,
-0.014595020562410355,
-0.015129020437598228,
0.02340036816895008,
-0.0021165634971112013,
0.02163778990507126,
0.009569096378982067,
-0.019134338945150375,
-0.0015843480359762907,
-0.007817905396223068,
0.004530747886747122,
-0.003904279787093401,
0.005354693625122309,
-0.013524412177503109,
-0.006973677780479193,
-0.053803496062755585,
0.004624166525900364,
0.012670316733419895,
-0.005714275874197483,
-0.02961939014494419,
0.01565704122185707,
-0.02348792552947998,
0.006451787427067757,
-0.0058857835829257965,
0.0012906065676361322,
0.002227975055575371,
0.0033001750707626343,
0.008983374573290348,
0.010919499211013317,
0.0039820619858801365,
-0.000836768711451441,
-0.019481685012578964,
0.0010072030127048492,
0.027747411280870438,
-0.004829917103052139,
-0.0051287696696817875,
-0.002848787233233452,
0.02006850205361843,
-0.00844361912459135,
-0.022604551166296005,
0.02288583479821682,
-0.008944690227508545,
0.0014822455123066902,
-0.004337640944868326,
0.0008544910233467817,
0.017220977693796158,
0.009743849746882915,
-0.008410990238189697,
-0.02407422661781311,
-0.032519564032554626,
0.01526299212127924,
-0.02829863876104355,
-0.02698507159948349,
-0.000553942983970046,
-0.021589118987321854,
0.0016280710697174072,
-0.017829982563853264,
0.029221676290035248,
0.0002951771020889282,
0.014789947308599949,
-0.013918380253016949,
0.0005017407238483429,
0.015869345515966415,
0.011183081194758415,
0.005465459078550339,
0.0028926299419254065,
-0.00046528875827789307,
-0.002435502829030156,
0.008132108487188816,
0.013771419413387775,
-0.020644482225179672,
0.008269106969237328,
0.0046471296809613705,
-0.011493121273815632,
0.020787732675671577,
0.014657240360975266,
0.01624971069395542,
-0.0030639811884611845,
0.0111241415143013,
-0.024411141872406006,
0.013032924383878708,
-0.010108939372003078,
0.008181722834706306,
-0.016171054914593697,
-0.0070217386819422245,
-0.0004974105395376682,
-0.0018372819758951664,
0.007770346477627754,
0.03424517810344696,
-0.008661588653922081,
0.01155543141067028,
0.009514945559203625,
0.009402414783835411,
-0.018650047481060028,
-0.009739505127072334,
0.005665904842317104,
0.03267742693424225,
-0.010817201808094978,
0.0030797747895121574,
0.023676307871937752,
0.01748943328857422,
0.006926770322024822,
0.010489074513316154,
0.002548870164901018,
-0.0029663252644240856,
0.010138219222426414,
-0.004840817302465439,
-0.018447965383529663,
-0.008360625244677067,
-0.006700088735669851,
0.018151840195059776,
0.012839706614613533,
-0.009827776812016964,
-0.02523161470890045,
-0.017212219536304474,
-0.016139985993504524,
0.033967092633247375,
0.01623428985476494,
-0.018571477383375168,
-0.004622415639460087,
0.007627744227647781,
-0.0017458358779549599,
0.008196031674742699,
0.014609339646995068,
-0.02995067834854126,
-0.011510735377669334,
0.019978642463684082,
0.021928632631897926,
0.0013492333237081766,
0.00879207905381918,
-0.0014718346064910293,
-0.010988384485244751,
-0.0037336451932787895,
0.010214788839221,
-0.01814340054988861,
-0.003457710612565279,
-0.010570351965725422,
0.010185223072767258,
0.003830119501799345,
0.02080635167658329,
-0.0011210455559194088,
0.017226066440343857,
0.00024012266658246517,
0.008155574090778828,
0.016799036413431168,
0.009478585794568062,
0.0003923458280041814,
0.00272703031077981,
0.01928253471851349,
0.014475183561444283,
0.006833689287304878,
-0.01194346696138382,
-0.009485720656812191,
-0.013987025246024132,
-0.0034247394651174545,
-0.004520614631474018,
0.00685840705409646,
0.007391834631562233,
0.032608672976493835,
-0.013841576874256134,
0.014731016010046005,
-0.00899379700422287,
-0.012472979724407196,
0.005609836429357529,
-0.017707452178001404,
-0.008886896073818207,
0.0031371978111565113,
-0.02312721684575081,
-0.0009018956916406751,
-0.014045354910194874,
0.0016888498794287443,
0.006217318121343851,
0.0034914128482341766,
-0.0072613670490682125,
-0.02148805558681488,
-0.0010456765303388238,
-0.00418645516037941,
0.00730537623167038,
-0.004612007178366184,
-0.010181082412600517,
0.003820040263235569,
0.008167851716279984,
-0.0177078228443861,
-0.00792890414595604,
0.00895942933857441,
0.004640636034309864,
0.009848153218626976,
-0.006072057876735926,
-0.004845959134399891,
0.019889604300260544,
-0.03783278912305832,
0.002794487401843071,
0.00691682193428278,
-0.0004112969618290663,
-0.009844489395618439
] | [
0.33642059564590454,
0.229397714138031,
0.03898552060127258,
-0.04384322836995125,
0.42283201217651367,
0.09555456787347794,
-0.12867286801338196,
0.29905521869659424,
-0.27461931109428406,
-0.3291853666305542,
0.06266102194786072,
0.22182950377464294,
-0.281119704246521,
0.06901303678750992,
-0.21321769058704376,
0.8481767773628235,
0.5370466709136963,
0.8241596817970276,
-0.20409533381462097,
-0.4856189489364624,
-0.17506487667560577,
-0.1518079787492752,
0.21586106717586517,
-0.09519888460636139,
0.2630119025707245,
-0.24766060709953308,
0.22452379763126373,
0.15424834191799164,
0.47145789861679077,
-0.08276143670082092,
-0.2528597414493561,
0.38751745223999023,
0.2398286610841751,
-0.2420770823955536,
-0.13075022399425507,
-0.3407565951347351,
-0.5092685222625732,
-0.2916071116924286,
-0.08088576048612595,
0.4568600058555603,
-0.2710232734680176,
-0.005319940857589245,
0.17113527655601501,
0.45774033665657043,
-0.21600480377674103,
-0.42245692014694214,
-1.896355390548706,
0.5189663171768188,
0.038306284695863724,
0.11768410354852676,
0.6434208154678345,
0.03517670929431915,
-0.09883784502744675,
0.19360245764255524,
0.243160679936409,
0.4115125834941864,
-0.7043839693069458,
-0.22437186539173126,
0.23534615337848663,
-0.5965980887413025,
-0.47820568084716797,
0.29084447026252747,
-0.22192271053791046,
0.027143817394971848,
-0.09333677589893341,
0.4676130414009094,
-0.006912567652761936,
-0.08036816865205765,
-0.6742763519287109,
-0.1098695695400238,
0.017254455015063286,
-0.3396824598312378,
-0.2538197934627533,
0.34152379631996155,
-0.3908165395259857,
-0.36489540338516235,
-0.2752549350261688,
-0.32456886768341064,
0.5215101838111877,
0.2911824882030487,
0.32511278986930847,
0.068974569439888,
0.29648035764694214,
0.14708854258060455,
0.526094377040863,
0.3487335443496704,
-0.447441428899765,
0.8392853140830994,
-0.2578456997871399,
-0.35496336221694946,
0.07087036967277527,
0.034103889018297195,
0.31652313470840454,
0.33133813738822937,
0.06761690229177475,
0.4963507354259491,
0.289000928401947,
-0.01834113895893097,
-0.21770553290843964,
0.2097657322883606,
-0.46656355261802673,
-0.0749526247382164,
-0.2846611738204956,
-0.2032700926065445,
-0.2970309853553772,
-0.09158104658126831,
0.05795033276081085,
-0.33814719319343567,
-0.36701229214668274,
0.18673747777938843,
-0.768498957157135,
-0.015591359697282314,
-0.5452406406402588,
-0.08033981919288635,
-0.17715151607990265,
-0.1977231502532959,
-0.3658057153224945,
-0.23761315643787384,
0.2107425034046173,
0.10805503278970718,
-0.1961417943239212,
1.2603315114974976,
-0.30980947613716125,
0.45725470781326294,
0.2108890265226364,
-0.13879413902759552,
-0.07836176455020905,
0.16673223674297333,
-0.3247477412223816,
0.4274417757987976,
0.6697808504104614,
0.6182724833488464,
-0.4738626182079315,
0.3129885792732239,
0.0410626195371151,
0.3971928060054779,
0.04792817682027817,
0.29102250933647156,
0.5594764351844788,
0.029238007962703705,
-0.84034264087677,
-0.7110394239425659,
-0.25793248414993286,
0.45682695508003235,
-0.20673036575317383,
-0.7262834310531616,
-0.21585655212402344,
0.02541104517877102,
-0.2488277405500412,
-0.49871090054512024,
0.22737476229667664,
-0.30401524901390076,
-0.7668370008468628,
-0.17789380252361298,
0.1276974231004715,
0.28782543540000916,
-0.042998529970645905,
-0.6993526816368103,
-0.09090012311935425,
0.4614395797252655,
0.0752469003200531,
-0.070768341422081,
-0.6502833962440491,
-0.3928815424442291,
0.5135090947151184,
-0.22216832637786865,
0.5407323241233826,
0.5012627243995667,
-0.3283171057701111,
-0.023858128115534782,
-0.7081937789916992,
-0.05914832651615143,
0.27013710141181946,
-0.6485849618911743,
0.49097740650177,
0.2659333646297455,
0.17402341961860657,
-0.15986268222332,
0.2167278230190277,
0.27112123370170593,
-0.8387846946716309,
-0.16999219357967377,
-0.36768585443496704,
-0.813431441783905,
0.5329487919807434,
-0.060958750545978546,
0.28035247325897217,
-0.15360523760318756,
0.0666973814368248,
-0.12352466583251953,
-0.5349350571632385,
-0.3184351325035095,
0.9088469743728638,
-0.2711428701877594,
1.4405182600021362,
-0.5060809850692749,
-0.24878273904323578,
0.9045515656471252,
0.4008328914642334,
-0.013941463083028793,
-0.3571482300758362,
-0.2244090586900711,
0.4972167909145355,
-0.3815334737300873,
-0.7290053963661194,
0.285807341337204,
0.19711613655090332,
-0.35839614272117615,
-0.029373537749052048,
0.2525464594364166,
0.4780062437057495,
-0.1422879993915558,
0.2049904614686966,
-0.31032562255859375,
0.2848493158817291,
-0.4636196792125702,
-0.2356187105178833,
-0.19963249564170837,
-0.6248032450675964,
0.02377675101161003,
0.053639788180589676,
-0.5770083069801331,
0.5423949956893921,
0.7090831995010376,
-0.12164992839097977,
0.6591021418571472,
0.8440549969673157,
0.053374361246824265,
0.8916375041007996,
-0.36996549367904663,
0.16457520425319672,
-0.40358296036720276,
-0.14273394644260406,
-0.4113527834415436,
-0.2762190103530884,
0.5754265785217285,
-0.029030317440629005,
0.19714099168777466,
-0.2491990625858307,
0.2633911967277527,
-0.10634272545576096,
0.4962749481201172,
-0.8440189361572266,
-0.016984235495328903,
-0.49288210272789,
-0.4252588152885437,
-0.3798874020576477,
0.3612382709980011,
-0.8627539277076721,
-0.026877451688051224,
-0.21335363388061523,
0.3245154321193695,
0.3256528973579407,
-0.4787742793560028,
-0.10209792107343674,
-0.26109829545021057,
-0.018275927752256393,
-0.4001360833644867,
0.33437004685401917,
-0.5378000140190125,
-0.15180757641792297,
0.22074292600154877,
0.27053165435791016,
0.10000991821289062,
0.38784995675086975,
-0.206093892455101,
-0.7095646262168884,
-0.40663591027259827,
0.7822374105453491,
0.7293103933334351,
1.0406414270401,
-0.24473132193088531,
-0.8854509592056274,
0.13438746333122253,
-0.1994641274213791,
-0.18200154602527618,
-0.10849633812904358,
0.7302208542823792,
-0.5342598557472229,
-0.41637852787971497,
-0.36728090047836304,
0.12592093646526337,
0.690186083316803,
0.0710710734128952,
-0.5491956472396851,
0.11312701553106308,
-0.1944410800933838,
-0.38899317383766174,
-0.5471921563148499,
-0.5323330163955688,
-0.15012279152870178,
-0.011602488346397877,
0.029945043846964836,
-0.28156477212905884,
0.2751455307006836,
0.2037578523159027,
-0.23169396817684174,
0.31902840733528137,
0.6903473734855652,
-0.17837414145469666,
0.025334393605589867,
0.20107969641685486,
-0.11164429038763046,
-0.2496393769979477,
0.06784029304981232,
-0.11322734504938126,
-0.06862153112888336,
0.25389334559440613,
-5.9520039558410645,
-0.04553116485476494,
-0.05255157873034477,
0.13555610179901123,
0.1285746693611145,
-0.12756188213825226,
1.233597755432129,
-0.06850934773683548,
0.219370499253273,
-0.0728306919336319,
0.11274795979261398,
0.3427989184856415,
0.07155101001262665,
-0.05482708662748337,
-0.15828590095043182,
-0.06868568062782288,
-0.15879477560520172,
-0.23432384431362152,
0.5585756301879883,
0.03766455873847008,
-0.009212569333612919,
-0.22944022715091705,
-0.3756810128688812,
0.6203075051307678,
0.3569572865962982,
0.08637091517448425,
-1.0305484533309937,
0.24348822236061096,
-0.26979807019233704,
0.12588004767894745,
-0.06353694945573807,
-0.522975742816925,
0.055906813591718674,
-0.3088028132915497,
0.19160397350788116,
0.021956169977784157,
-0.1950821876525879,
-0.24950571358203888,
-0.13203217089176178,
0.07168912142515182,
0.11194845288991928,
0.3715645968914032,
-0.35661402344703674,
-0.31040868163108826,
0.09090597927570343,
-0.20177999138832092,
0.10656283795833588,
0.02460644021630287,
-0.33410051465034485,
0.836968183517456,
-0.1025187224149704,
0.01943482831120491,
0.1573740541934967,
0.4127860963344574,
0.5843093395233154,
0.04362890496850014,
-0.22266659140586853,
0.0727488324046135,
-0.1570112258195877,
0.15181298553943634,
-0.07515784353017807,
-0.11857733130455017,
-0.13501045107841492,
-0.41679278016090393,
-0.055206649005413055,
0.4929226338863373,
-0.2602221667766571,
-0.3574853241443634,
0.49065491557121277,
-0.19750918447971344,
-0.23890109360218048,
0.5385396480560303,
0.4749794006347656,
-0.7080376148223877,
0.4016924202442169,
-0.2112976759672165,
-0.39696258306503296,
-0.07369951903820038,
0.13464172184467316,
0.19608086347579956,
-0.19323424994945526,
0.029321685433387756,
0.10094066709280014,
-0.1899544894695282,
-0.33793139457702637,
-0.3647652566432953,
-0.12745735049247742,
0.2827070951461792,
-0.3327745497226715,
0.6186552047729492,
0.3957807719707489,
-0.22908470034599304,
0.13229918479919434,
0.6329879760742188,
0.16254377365112305,
0.6566460132598877,
0.2583799660205841,
0.48500895500183105,
0.36583995819091797,
0.38139423727989197,
0.6498033404350281,
-0.031545862555503845,
-0.25292906165122986,
-0.42402148246765137,
0.23205909132957458,
-0.1956971287727356,
-0.12810686230659485,
0.03699999675154686,
0.517898440361023,
-0.9615796804428101,
0.24821653962135315,
0.2642911970615387,
-0.10365267843008041,
-0.48094505071640015,
0.7151619791984558,
-0.10018064826726913,
0.1852545142173767,
-0.15301303565502167,
0.7344359159469604,
-0.3208961486816406,
0.442163348197937,
0.282654732465744,
-0.6518779397010803,
0.3297002613544464,
0.03546811267733574,
-0.296630322933197,
0.5452520847320557,
0.5189362168312073,
-0.43265852332115173,
-0.050748445093631744,
0.22723522782325745,
0.6846373677253723,
-0.14947153627872467,
-0.01805851235985756,
0.20468048751354218,
-0.2446354478597641,
-0.1334839165210724,
0.47286292910575867,
0.2760199308395386,
-0.09416792541742325,
0.3468656837940216,
-0.3030306100845337,
-0.21167702972888947,
-0.0765315592288971,
0.10348650813102722,
0.46144285798072815,
-0.05434810370206833,
0.3006027042865753,
0.1263541430234909,
-0.2793390154838562,
0.15175440907478333,
-0.1289394348859787,
0.27870532870292664,
0.10888543725013733,
0.07775008678436279,
0.04681455343961716,
0.42554882168769836,
0.20629270374774933,
0.3191564679145813,
-0.6697346568107605,
0.3784186542034149,
-0.15557542443275452,
-1.0952333211898804,
-0.19659529626369476,
-0.07808055728673935,
-0.6197118759155273,
0.044285546988248825,
-0.8919986486434937,
0.1333586424589157,
0.2150074988603592,
-0.5650378465652466,
-0.24807582795619965,
-0.13565358519554138,
-0.10582777857780457,
0.17774146795272827,
-0.6325764060020447,
-0.08908966183662415,
0.017965659499168396,
-0.5620056390762329,
-0.10128995776176453,
0.3592792749404907,
-0.5759817957878113,
-0.16801580786705017,
0.3712003529071808,
0.7528048157691956,
0.0873403251171112,
0.08162817358970642,
-0.03232390433549881,
-0.014295092783868313,
-0.2835894823074341,
-0.27829137444496155,
0.31201452016830444,
0.36728397011756897,
-0.037281107157468796,
0.23175783455371857,
0.3209287226200104,
0.16735495626926422,
0.16981565952301025,
0.2932651937007904,
-0.5260014533996582,
-0.05147097259759903,
0.45465829968452454,
-0.4060222804546356,
0.13558414578437805,
0.3409198820590973,
0.23268809914588928,
0.03809940442442894,
-0.09430474787950516,
-0.03882226347923279,
-0.22421978414058685,
-0.33935144543647766,
-0.7319245934486389,
-0.2740451991558075,
0.27347075939178467,
-0.09837522357702255,
0.032304298132658005,
0.3227757513523102,
0.23051360249519348,
-0.29312071204185486,
0.4200652241706848,
0.47887369990348816,
-0.15209530293941498,
-0.12714284658432007,
0.10402646660804749,
-0.31027963757514954,
0.2870216965675354,
0.22174057364463806,
-0.8564354181289673,
0.3542974591255188,
0.04923687502741814,
-0.3263164460659027,
-0.24186934530735016,
0.10120486468076706,
0.30654698610305786,
-0.25914955139160156,
-0.3227578401565552,
0.03850848972797394,
0.21675488352775574,
-0.2594793438911438,
0.07715844362974167,
0.3744807243347168,
0.4397963583469391,
-0.524131178855896,
-0.28630802035331726,
-0.221831813454628,
0.5589510798454285,
0.29116347432136536,
-0.5187730193138123,
-0.40788811445236206,
-0.06168682128190994,
0.4482439458370209,
-0.2544417977333069,
0.48863157629966736,
0.3610247075557709,
0.5976290106773376,
-0.07435277104377747,
-0.15582773089408875,
-0.15465696156024933,
-0.08928235620260239,
0.3099411129951477,
-0.1526428461074829,
-0.09949318319559097,
-0.06013054400682449,
-0.13416098058223724,
0.14774730801582336,
0.1938096135854721,
-0.2833788990974426,
-0.41510266065597534,
0.1972712278366089,
-0.09425299614667892,
0.08378811180591583,
0.23463496565818787,
0.6739696860313416,
0.6670101881027222,
0.25971555709838867,
0.5231733322143555,
-0.6256625056266785,
-0.3323616683483124,
-0.19310899078845978,
0.41449907422065735,
-0.101219043135643,
-0.7192621231079102,
0.2856568992137909,
-0.5314741134643555,
0.33774101734161377,
-0.5694314241409302,
0.18924188613891602,
-0.3208142817020416,
0.030955785885453224,
-0.28855741024017334,
-0.3700936734676361,
-0.08576507866382599,
-0.4648696184158325,
-1.0250632762908936,
0.23380105197429657,
0.05618825554847717,
-0.2041114717721939,
0.04586220532655716,
0.32112693786621094,
-0.2523511052131653,
-0.6497576236724854,
0.3612717390060425,
0.4623247981071472,
-0.2721339464187622,
0.0862618014216423,
0.343326598405838,
-0.11701414734125137,
0.08916043490171432,
-0.47304245829582214,
-0.056159839034080505,
0.43757155537605286,
-0.11547838151454926,
-0.011060286313295364,
0.35828137397766113,
-0.2216612547636032,
0.05090007185935974,
-0.41916197538375854,
-0.4137099087238312,
0.2550055980682373,
0.6110171675682068,
0.27226710319519043,
0.5743048787117004,
0.2662191092967987,
-0.418010413646698,
0.007384319324046373,
0.04827110096812248,
0.006163544952869415,
0.6259928941726685,
0.09455318748950958,
0.4281337261199951,
0.4285396933555603,
0.4571399688720703,
-0.026033557951450348,
0.8307098746299744,
0.6278983950614929,
0.14749208092689514,
0.2532639503479004,
-0.8043581247329712,
0.041104644536972046,
0.07614009082317352,
0.8555433750152588,
0.02428157441318035,
-0.24809952080249786,
-0.38137713074684143,
0.2615469992160797,
0.24022552371025085,
-0.09617540240287781,
-0.07610748708248138,
-0.37740635871887207,
0.6571509838104248,
-0.11303126811981201,
-0.3006763458251953,
-0.623315155506134,
-0.2457369565963745,
-0.42976614832878113,
0.3312786817550659,
0.27757734060287476,
-0.3579709529876709,
-0.7597039341926575,
0.2543201148509979,
-0.15535534918308258,
0.3941357135772705,
0.005166195798665285,
0.7115345597267151,
-0.039675865322351456,
0.030486583709716797,
0.46222516894340515,
-0.08446042984724045,
0.2951161563396454,
0.00909453071653843,
0.08188049495220184,
-0.3330022990703583,
-0.05913995951414108,
-0.07250107824802399,
0.5268637537956238,
-0.14483462274074554,
0.41016802191734314,
0.22910892963409424,
-0.23038561642169952,
0.43169042468070984,
-0.31641367077827454,
0.0910307914018631,
-0.25490081310272217,
-0.14273878931999207,
-0.22461555898189545,
-0.17602069675922394,
-0.4051966667175293,
0.05702614039182663,
0.2832825481891632,
0.08364540338516235,
0.044071491807699203,
-0.8026481866836548,
0.4297049045562744,
0.3934330344200134,
0.3091713488101959,
-0.1748812347650528,
-0.043610211461782455,
-0.04275812208652496,
0.47811615467071533,
0.01848183572292328,
0.1018972173333168,
0.1894114911556244,
-0.07507093250751495,
0.27372658252716064,
-0.5286563038825989,
0.4350658357143402,
-0.6009542942047119,
-0.4574877917766571,
-0.5316950678825378,
-0.2940908670425415,
0.8033457398414612,
0.5266291499137878,
-0.4898340702056885,
0.03674722835421562,
0.4236523509025574,
0.21250896155834198,
0.3314647674560547,
-0.43354639410972595,
-0.08075448870658875,
-0.7914404273033142,
0.1259552389383316,
-0.2976360321044922,
0.6015011668205261,
-0.3332105576992035,
-0.1640680879354477,
-0.07367367297410965,
0.4678526818752289,
0.21775159239768982,
-0.3127421736717224,
0.37902864813804626,
-0.5724478363990784,
0.251412034034729,
-0.8684876561164856,
0.31316909193992615,
-0.4072655439376831,
0.2807479798793793,
0.09771642088890076,
0.17665116488933563,
0.06613437086343765,
-0.267218679189682,
0.170321524143219,
-0.06635627895593643,
-0.2843826711177826,
-0.1670711189508438,
0.0877891406416893,
0.21867942810058594,
-0.12880723178386688,
-0.5026220083236694,
-0.24612021446228027,
-0.15511739253997803,
0.2201031744480133,
-0.36801308393478394,
-0.10925362259149551,
0.14723196625709534,
-0.10321977734565735,
-0.27337387204170227,
0.16937442123889923,
-0.3002069890499115,
-0.06083492562174797,
-0.06539025902748108
] |
The major histocompatibility complex (MHC) class I B gene/allelic repertoire was investigated in a pedigreed population of cynomolgus macaques of mixed Indonesian/Malaysian origin. The Mafa-B alleles detected in this cohort are mostly specific for a given geographic area, and only a small number of alleles appears to be shared with other populations. This suggests the fast evolution of Mafa-B alleles due to adaptation to new environments. In contrast to humans, the B locus in Old World monkeys displays extensive copy number variation. The Mafa-B and previously defined -A gene combinations segregate in families and thus allowed the definition of extended haplotypes. In many cases it was possible to assign a particular Mafa-I allele to one of these Mafa-A/B haplotypes as well. The presence of a large number of stable haplotypes in this cohort of animals, which was pedigreed for up to eight generations, looks promising for developing discriminative MHC typing tools that are less cumbersome. Furthermore, the discovery of 53 unreported Mafa-B sequences expands the lexicon of alleles significantly, and may help in understanding the complex organisation of the macaque B region. | [
-0.016051437705755234,
0.027580056339502335,
0.0006499816663563251,
0.013425877317786217,
0.014369409531354904,
-0.0048255170695483685,
0.009821209125220776,
-0.005147751420736313,
-0.017774522304534912,
0.006026845425367355,
-0.005070846993476152,
0.016655389219522476,
0.0015032426454126835,
0.010560738854110241,
-0.03478826954960823,
0.02258343994617462,
-0.009176576510071754,
0.014743179082870483,
0.014641063287854195,
0.008672469295561314,
0.000985937425866723,
-0.005083154421299696,
0.01004848349839449,
0.026353023946285248,
-0.009394711814820766,
-0.007857399992644787,
-0.032838039100170135,
0.018781527876853943,
0.00662743765860796,
0.01153906062245369,
0.014061331748962402,
0.011702340096235275,
-0.010202709585428238,
0.009256884455680847,
0.0062170978635549545,
0.007795702666044235,
-0.001513029565103352,
0.024595221504569054,
-0.011209003627300262,
-0.004353223834186792,
-0.0007647210732102394,
-0.009441034868359566,
-0.0005684676580131054,
-0.027936559170484543,
-0.01145192701369524,
-0.02386103942990303,
-0.006590951234102249,
0.03017480857670307,
0.00040967646054923534,
0.006554786115884781,
-0.005975347012281418,
-0.04532032459974289,
-0.007590579800307751,
-0.021171679720282555,
-0.0062688663601875305,
-0.0012589084217324853,
0.018221978098154068,
-0.012988459318876266,
0.02490307204425335,
-0.0010295389220118523,
-0.0001294477842748165,
-0.02855004370212555,
0.017027150839567184,
0.0023735640570521355,
-0.01904420182108879,
-0.0668666884303093,
-0.00018771225586533546,
0.02054722234606743,
-0.009405957534909248,
-0.010719841346144676,
-0.02654889225959778,
0.010768288746476173,
-0.006400114856660366,
-0.0021800522226840258,
0.0201583169400692,
-0.01641480252146721,
-0.02439020201563835,
0.004992347210645676,
0.023183660581707954,
0.017249029129743576,
-0.010845867916941643,
-0.008846975862979889,
0.03196488320827484,
0.016291944310069084,
-0.007671861909329891,
0.003774050623178482,
-0.03910771757364273,
0.00501495273783803,
0.001377247623167932,
-0.006687567103654146,
0.016806185245513916,
-0.004186753649264574,
0.006474528461694717,
-0.009199708700180054,
-0.0203159898519516,
-0.00866242591291666,
-0.017810240387916565,
-0.016271784901618958,
0.008835802786052227,
-0.006426564417779446,
-0.00755486311390996,
0.004354007542133331,
0.019386999309062958,
0.00338424532674253,
0.015875978395342827,
0.008209353312849998,
0.005214731674641371,
-0.01807192899286747,
0.022565845400094986,
0.008060723543167114,
-0.012519348412752151,
0.0005338499322533607,
-0.03340120241045952,
0.007033590227365494,
-0.0045910002663731575,
0.01872163824737072,
-0.00540239829570055,
-0.01989707536995411,
0.006000710651278496,
-0.016201477497816086,
0.021810058504343033,
-0.002628364134579897,
-0.014896363019943237,
0.0016079978086054325,
0.006193794310092926,
-0.015308646485209465,
-0.006669867318123579,
0.002380899153649807,
0.021533779799938202,
-0.0032815360464155674,
-0.007912464439868927,
0.006297598127275705,
0.006954751908779144,
0.01564895734190941,
0.0345030277967453,
0.001599036157131195,
-0.0421493723988533,
-0.007050389423966408,
-0.006700933910906315,
0.009365520440042019,
-0.008993266150355339,
0.011637517251074314,
0.00466238334774971,
0.00405234145000577,
0.011072523891925812,
0.0074051059782505035,
-0.03115086629986763,
0.015163775533437729,
0.031549252569675446,
0.0018202047795057297,
0.02194821462035179,
-0.021809186786413193,
-0.018530607223510742,
-0.017836052924394608,
-0.010186786763370037,
0.010614205151796341,
-0.014905091375112534,
-0.03185385465621948,
-0.013176657259464264,
0.020756186917424202,
-0.012672029435634613,
-0.02717084251344204,
0.015097207389771938,
0.01029787864536047,
0.02925778552889824,
-0.003698420710861683,
-0.014602898620069027,
-0.0085966931656003,
-0.0160868801176548,
0.009039608761668205,
0.004930802155286074,
0.03095092996954918,
-0.005973937455564737,
0.00638702604919672,
0.0027935178950428963,
0.0016965311951935291,
0.023187434300780296,
0.006270211189985275,
-0.009741540066897869,
0.06671154499053955,
0.030630571767687798,
0.014854813925921917,
-0.02686648815870285,
0.009409941732883453,
0.03295449912548065,
-0.03403851389884949,
0.0068030087277293205,
-0.003781442064791918,
-0.03387252986431122,
-0.006586433853954077,
0.008882155641913414,
0.014537838287651539,
-0.02830219455063343,
-0.020472414791584015,
-0.01563735119998455,
0.0011393558233976364,
-0.024294517934322357,
0.01414879597723484,
0.01230049878358841,
-0.010939999483525753,
-0.042928799986839294,
0.004077553749084473,
0.021190542727708817,
-0.018177000805735588,
-0.037664271891117096,
0.020653190091252327,
0.04262540489435196,
0.028589844703674316,
-0.027495985850691795,
-0.021818239241838455,
0.002192352432757616,
-0.0023298952728509903,
0.0014294828288257122,
-0.026730380952358246,
-0.0013184593990445137,
-0.0006422519218176603,
0.0006044777110219002,
0.018996845930814743,
0.0017344688531011343,
-0.014901364222168922,
-0.006296628620475531,
-0.005288280081003904,
-0.02511443942785263,
-0.0017955843359231949,
-0.015246054157614708,
-0.012848183512687683,
0.003257788484916091,
0.0075361584313213825,
0.006611899472773075,
-0.0002311177086085081,
-0.022145269438624382,
-0.008335452526807785,
-0.012750928290188313,
0.020754214376211166,
-0.030294159427285194,
0.01724477857351303,
0.013699386268854141,
0.005953099112957716,
0.01225217618048191,
-0.007642296142876148,
-0.019059769809246063,
-0.012229125015437603,
0.010556899011135101,
-0.02325049787759781,
0.005841167643666267,
-0.02265350893139839,
0.04946716129779816,
0.008696509525179863,
0.010583476163446903,
0.0007136878557503223,
0.009082935750484467,
-0.0030113065149635077,
0.014912493526935577,
0.0034027709625661373,
-0.0035514459013938904,
-0.02356831356883049,
-0.032080743461847305,
0.028607888147234917,
0.024662766605615616,
0.001479526748880744,
0.005869705229997635,
0.0014139459235593677,
0.0012769282329827547,
0.029106002300977707,
-0.000029702670872211456,
0.0315675251185894,
0.007719063200056553,
-0.0060941800475120544,
-0.004432457499206066,
-0.021684706211090088,
0.006781293079257011,
-0.0020679559092968702,
0.00349795981310308,
-0.08165225386619568,
-0.009394649416208267,
-0.023374397307634354,
-0.02146931365132332,
0.004476004745811224,
0.019947081804275513,
-0.008685274049639702,
-0.00843249261379242,
-0.003712623380124569,
-0.01058419793844223,
0.01915525272488594,
-0.025910066440701485,
-0.0037291282787919044,
-0.011130964383482933,
0.0204829853028059,
0.003315807320177555,
0.012045332230627537,
-0.045266907662153244,
-0.00543876551091671,
-0.027885660529136658,
-0.0013487233081832528,
0.0024948520585894585,
0.01847677119076252,
-0.0005157459527254105,
-0.03349962830543518,
-0.0081153754144907,
0.002139824675396085,
0.014839019626379013,
0.010453415103256702,
0.0034599772188812494,
-0.019442401826381683,
-0.031508028507232666,
-0.00426133256405592,
0.002026383066549897,
0.023634854704141617,
-0.022234126925468445,
0.008132417686283588,
0.011329159140586853,
-0.02890045754611492,
-0.00010306667536497116,
-0.029420144855976105,
0.02332204394042492,
0.0187359806150198,
-0.009568621404469013,
0.007733382750302553,
0.0050243716686964035,
0.012436321005225182,
0.014244452118873596,
0.02276596799492836,
-0.005776905454695225,
0.004307852126657963,
-0.010927638038992882,
0.008008565753698349,
0.010575605556368828,
-0.011088347062468529,
-0.008853373117744923,
-0.006103367079049349,
-0.008034346625208855,
-0.011204881593585014,
-0.005071406252682209,
-0.023824645206332207,
-0.0008334933081641793,
0.024635890498757362,
0.01066747959703207,
-0.018645239993929863,
0.02892390638589859,
0.006245763972401619,
-0.025696681812405586,
-0.013350674882531166,
0.01576443761587143,
-0.004621187224984169,
-0.015466228127479553,
-0.0025757704861462116,
-0.01246700994670391,
0.011545092798769474,
-0.004257066175341606,
-0.013480260036885738,
-0.002779022790491581,
0.009838773868978024,
-0.006387664936482906,
-0.005836901254951954,
-0.008069569244980812,
0.009256991557776928,
-0.012268048711121082,
-0.019072245806455612,
-0.001448124647140503,
0.011331198737025261,
0.019854243844747543,
0.007232587784528732,
-0.012002821080386639,
-0.018251433968544006,
-0.010970020666718483,
-0.0126132071018219,
0.011807240545749664,
0.006537634413689375,
0.03081495314836502,
0.021865660324692726,
-0.009676497429609299,
-0.0005430728197097778,
0.007435648702085018,
-0.01256002951413393,
-0.006901745218783617,
-0.015167880803346634,
-0.010836660861968994,
0.009315761737525463,
0.013834789395332336,
0.010340110398828983,
0.012200508266687393,
-0.006294209975749254,
-0.003990110009908676,
0.027579598128795624,
0.01457642950117588,
-0.0038525715935975313,
-0.0001280300784856081,
0.019756583496928215,
0.018458886072039604,
-0.026905827224254608,
-0.02868984453380108,
0.0722358226776123,
-0.006633811630308628,
-0.0017504533752799034,
-0.020532768219709396,
0.047015801072120667,
-0.00472046434879303,
-0.00863509438931942,
0.0037301951088011265,
-0.01783839240670204,
0.0007254262454807758,
0.012358412146568298,
-0.0037377970293164253,
-0.022983329370617867,
0.001037647482007742,
-0.005292197223752737,
0.019088510423898697,
0.014285949058830738,
-0.01968204416334629,
0.05828411877155304,
0.01419984083622694,
-0.01739249750971794,
-0.04020608589053154,
-0.01146034337580204,
-0.008216505870223045,
0.006958550773561001,
-0.028258495032787323,
-0.016980940476059914,
-0.011313647031784058,
-0.004134283866733313,
0.007493374869227409,
0.00630095973610878,
0.030329197645187378,
-0.012321257963776588,
0.0017321337945759296,
0.01569596491754055,
0.013673165813088417,
0.028347540646791458,
0.00984061136841774,
-0.0008846740238368511,
-0.018422719091176987,
-0.002259586937725544,
-0.016276955604553223,
0.003283057827502489,
0.005919668357819319,
-0.03888005018234253,
0.005204980727285147,
0.008118730038404465,
-0.0065952688455581665,
-0.010301354341208935,
-0.006740051321685314,
0.002630547620356083,
0.0006084761116653681,
0.009916413575410843,
0.021474255248904228,
0.002656857715919614,
0.005956860259175301,
0.021840756759047508,
-0.006561916321516037,
0.008028500713407993,
0.0004988983273506165,
-0.022946245968341827,
0.010239658877253532,
-0.00038212118670344353,
-0.005337350070476532,
-0.02299065701663494,
-0.006216289475560188,
-0.02366103231906891,
0.011174769140779972,
0.0005964105948805809,
0.02379125915467739,
0.029210366308689117,
-0.011563390493392944,
-0.01315801590681076,
0.0018231896683573723,
-0.017728425562381744,
-0.0325046069920063,
-0.0017881379462778568,
0.002712945220991969,
-0.011441133916378021,
0.020030636340379715,
0.003484823741018772,
-0.0035302317701280117,
0.004141009412705898,
0.025235548615455627,
-0.013129878789186478,
-0.015234677121043205,
-0.012065030634403229,
-0.07461868971586227,
0.02603836916387081,
-0.00724363885819912,
-0.0017902207328006625,
0.013790996745228767,
0.008904478512704372,
-0.018075065687298775,
0.0008245445787906647,
0.007673259824514389,
-0.015562331303954124,
-0.023314218968153,
0.012452386319637299,
0.0074454257264733315,
-0.007103641051799059,
0.011347606778144836,
0.03034871630370617,
-0.023527737706899643,
-0.006608331575989723,
-0.04613348841667175,
-0.011891315691173077,
0.002937336452305317,
0.007552469149231911,
-0.010523107834160328,
0.01896579936146736,
-0.00402114586904645,
-0.08122522383928299,
-0.007236459292471409,
0.017446355894207954,
0.014772890135645866,
0.0015892366645857692,
0.0033352028112858534,
0.0142039954662323,
-0.018918821588158607,
-0.025266263633966446,
-0.016222115606069565,
-0.0008106038440018892,
-0.00716816121712327,
0.01000357884913683,
-0.010215362533926964,
0.010061133652925491,
-0.006568449083715677,
0.026918191462755203,
0.029669415205717087,
-0.013356156647205353,
0.009794741868972778,
-0.0005255811265669763,
-0.01853102073073387,
-0.010313453152775764,
0.0022107483819127083,
-0.004331798758357763,
-0.007667544297873974,
-0.03017503209412098,
0.020809121429920197,
0.0015653958544135094,
0.02757418528199196,
-0.004359479993581772,
-0.0025353780947625637,
-0.00928935594856739,
-0.010285788215696812,
-0.02204052172601223,
-0.021492844447493553,
-0.006021514534950256,
-0.018819455057382584,
0.00981175433844328,
0.004741867538541555,
-0.005321102682501078,
-0.0024678970221430063,
-0.00004368904046714306,
-0.004349282942712307,
0.0017784638330340385,
0.00942220352590084,
0.005462652072310448,
-0.006102011539041996,
0.0041521284729242325,
0.010118738748133183,
0.005854868795722723,
0.03380010649561882,
0.005839299410581589,
-0.004719131626188755,
0.01979636400938034,
0.02206648327410221,
0.005012383218854666,
0.01639128476381302,
0.02719874121248722,
0.013347900472581387,
0.007974657230079174,
0.012587783858180046,
0.014611919410526752,
0.07180823385715485,
-0.03015817329287529,
0.020212888717651367,
-0.012854063883423805,
-0.003093500854447484,
0.003297637915238738,
-0.005989053752273321,
0.030912255868315697,
0.008576766587793827,
-0.017816662788391113,
-0.011307217180728912,
-0.009053641930222511,
-0.009827839210629463,
0.019871113821864128,
0.02085132710635662,
-0.030156683176755905,
0.015198496170341969,
0.001409559161402285,
-0.035702526569366455,
-0.008245769888162613,
-0.014219673350453377,
0.005527868401259184,
-0.0005437898216769099,
0.003054637461900711,
-0.017260456457734108,
-0.009177913889288902,
-0.010576017200946808,
0.009138764813542366,
-0.018486758694052696,
0.008014190942049026,
-0.02827339805662632,
0.010693815536797047,
0.008563727140426636,
-0.023251639679074287,
-0.009502062574028969,
-0.006195738911628723,
0.009632854722440243,
0.018139071762561798,
0.018592726439237595,
0.029912367463111877,
-0.009463973343372345,
0.0032465192489326,
0.0032406095415353775,
-0.009993012994527817,
0.0032481634989380836,
0.006173646077513695,
0.001223330618813634,
0.016240835189819336,
0.022737815976142883,
0.010666134767234325,
-0.005255020223557949,
0.007882269099354744,
0.013253388926386833,
-0.00006904650945216417,
-0.000006163027137517929,
0.0002056232187896967,
-0.007277959026396275,
0.01707017794251442,
-0.015409998595714569,
0.016891056671738625,
-0.0038911395240575075,
0.004884843714535236,
-0.015333568677306175,
-0.016314366832375526,
0.021660935133695602,
0.009908802807331085,
0.00598317664116621,
-0.014574529603123665,
0.002007940784096718,
0.013785488903522491,
-0.0027867290191352367,
-0.026913661509752274,
0.00604111235588789,
0.00833312701433897,
0.0021265768446028233,
0.008703282102942467,
-0.0010782605968415737,
0.002492670202627778,
-0.0025644381530582905,
0.010106394067406654,
-0.001621505944058299,
-0.013194798491895199,
0.009372301399707794,
-0.007661961950361729,
-0.020042771473526955,
0.028541147708892822,
0.012500681914389133,
0.019155601039528847,
0.0030292500741779804,
0.007815148681402206,
0.024564078077673912,
0.004632470663636923,
-0.00428106589242816,
0.01676034927368164,
0.009127849712967873,
0.03413882851600647,
0.0033917163964360952,
0.010058114305138588,
0.00657487940043211,
-0.000680119264870882,
0.009748938493430614,
0.014806120656430721,
0.011209199205040932,
-0.015469707548618317,
-0.025833122432231903,
-0.00888742320239544,
0.017294086515903473,
-0.005182045977562666,
0.017803210765123367,
-0.004410531837493181,
-0.004533066414296627,
-0.024396024644374847,
-0.02885288931429386,
-0.012990267015993595,
0.012885665521025658,
0.025937581434845924,
0.0031888731755316257,
-0.001417388441041112,
0.034505851566791534,
-0.018320776522159576,
-0.04169896990060806,
-0.01224538404494524,
-0.005989620462059975,
0.0027716830372810364,
0.005601504351943731,
-0.007364253979176283,
-0.01069376990199089,
0.0137014864012599,
-0.0039938464760780334,
0.004077148623764515,
0.01659483090043068,
-0.0027726907283067703,
0.055428192019462585,
0.020092030987143517,
-0.019278183579444885,
-0.002508314326405525,
0.009118307381868362,
0.018012672662734985,
0.01421897578984499,
-0.013085120357573032,
0.01841399073600769,
-0.016592495143413544,
0.004395177587866783,
0.009611391462385654,
0.00760215800255537,
-0.024978764355182648,
-0.002471575979143381,
-0.0071371193043887615,
0.010300176218152046,
-0.023785609751939774,
-0.02618616819381714,
0.0037648777943104506,
-0.005010940600186586,
-0.0065289451740682125,
0.004773276392370462,
-0.001520374440588057,
-0.0015720257069915533,
-0.001974885817617178,
0.003718928899616003,
-0.004582938738167286,
-0.019143428653478622,
0.0032560639083385468,
-0.04033965617418289,
-0.017658917233347893,
0.0037686359137296677,
0.0000888509675860405,
-0.02896963059902191,
0.024914203211665154,
-0.020065926015377045,
-0.002008802955970168,
0.012562325224280357,
-0.009717559441924095,
0.006002947222441435,
0.004923054948449135,
-0.0341343991458416,
-0.006903252564370632,
0.0020913071930408478,
0.016474496573209763,
-0.015645580366253853,
0.019630806520581245,
0.009181889705359936,
0.004094690550118685,
-0.01703372411429882,
-0.00860322080552578,
0.009425383992493153,
-0.005989406257867813,
-0.0048210108652710915,
0.006813199259340763,
-0.00039706239476799965,
0.008066853508353233,
0.00474842544645071,
-0.022639427334070206,
-0.011105801910161972,
0.017138388007879257,
0.011982131749391556,
-0.003823784412816167,
0.012641990557312965,
-0.00917673297226429,
-0.0026940936222672462,
0.01312467735260725,
0.02068112976849079,
-0.0016224798746407032
] | [
0.2986588180065155,
-0.02117042988538742,
-0.2681399881839752,
-0.09003712981939316,
0.21962587535381317,
0.2676944434642792,
0.4607427716255188,
-0.1066945269703865,
-0.17931672930717468,
-0.21018223464488983,
-0.3332858681678772,
-0.10506848245859146,
-0.8361440896987915,
0.10641885548830032,
-0.09523828327655792,
0.713870108127594,
0.47269493341445923,
0.36137863993644714,
-0.3101250231266022,
-0.4707232117652893,
-0.09405700117349625,
-0.42486125230789185,
0.20295728743076324,
0.14215174317359924,
0.09965813905000687,
0.11917008459568024,
0.5071503520011902,
0.3244799077510834,
0.42908450961112976,
-0.2607833743095398,
0.052830711007118225,
0.6436781287193298,
0.2613265812397003,
-0.22366316616535187,
-0.6133012175559998,
-0.0621926411986351,
-0.36653995513916016,
-0.23247352242469788,
0.34595000743865967,
-0.2947068214416504,
0.16393159329891205,
-0.04221918806433678,
0.07757223397493362,
0.8344419598579407,
-0.37322676181793213,
-0.4221291244029999,
-1.4712061882019043,
0.6413721442222595,
-0.5381647348403931,
-0.06808706372976303,
0.030347749590873718,
0.10777688771486282,
0.029223889112472534,
0.0759376734495163,
0.0016588433645665646,
0.5102784037590027,
-0.46276217699050903,
-0.07163479179143906,
0.4470439851284027,
-0.576304018497467,
-0.0035470605362206697,
-0.4096558392047882,
0.3148711621761322,
0.3835058808326721,
-0.2401697039604187,
0.49633845686912537,
0.012794355861842632,
-0.6210113763809204,
-0.20436042547225952,
0.16874447464942932,
0.0635136291384697,
0.06713492423295975,
-0.3495354950428009,
0.2425113171339035,
-0.24272622168064117,
0.10571527481079102,
-0.44176822900772095,
-0.2487744837999344,
0.07637345045804977,
0.05791330337524414,
-0.2671493589878082,
-0.022916140034794807,
0.1231139525771141,
-0.42444080114364624,
0.2605692446231842,
0.580815315246582,
0.29761600494384766,
-0.022357353940606117,
-0.6201446056365967,
0.5953006148338318,
-0.41263464093208313,
-0.12269831448793411,
0.32121381163597107,
0.5073447227478027,
0.19506140053272247,
0.10258509963750839,
0.1382637321949005,
-0.2549654245376587,
0.12243346124887466,
-0.14356692135334015,
-0.4978954792022705,
-0.06757035851478577,
0.2553068995475769,
-0.2510055899620056,
-0.9852278828620911,
-0.08595873415470123,
-0.4049716591835022,
-0.4319981336593628,
-0.4808138906955719,
0.0903184786438942,
-0.676190197467804,
-0.2596171498298645,
0.18268662691116333,
-0.1603095531463623,
0.25221309065818787,
0.034477390348911285,
0.11144828796386719,
-0.4422016143798828,
0.056312162429094315,
0.28119850158691406,
-0.1560574769973755,
1.4813393354415894,
-0.6455488204956055,
0.400089830160141,
-0.03851562738418579,
-0.403617799282074,
0.19114144146442413,
-0.16746370494365692,
-0.16779688000679016,
0.7448707222938538,
0.35051295161247253,
0.23219816386699677,
0.0866798684000969,
0.1137886792421341,
-0.2434302419424057,
0.1376277357339859,
0.11730602383613586,
0.13853178918361664,
-0.11954450607299805,
-0.014628232456743717,
-0.8057367205619812,
-0.39152365922927856,
-0.210845947265625,
0.019895171746611595,
0.37709861993789673,
-0.07670749723911285,
-0.2764397859573364,
-0.11501574516296387,
0.17603933811187744,
-0.35568711161613464,
0.025312775745987892,
-0.3389334976673126,
-0.3787735104560852,
-0.18099333345890045,
-0.10849327594041824,
0.5977545976638794,
0.07551844418048859,
-0.18253172934055328,
0.29727163910865784,
0.260532021522522,
-0.05483590066432953,
0.03147796913981438,
-0.10872773081064224,
-0.42966052889823914,
0.110052689909935,
0.2978009581565857,
0.399040549993515,
0.9269142746925354,
-0.7542141675949097,
0.05107302591204643,
0.058447662740945816,
-0.679643988609314,
0.18313635885715485,
-0.6118001341819763,
-0.9355441927909851,
-0.48979368805885315,
0.10590113699436188,
-0.24787913262844086,
0.2516154944896698,
0.2792842984199524,
-0.5714548826217651,
0.06432744115591049,
0.08897840976715088,
-0.2829363942146301,
0.27580949664115906,
0.22101108729839325,
0.27064236998558044,
0.09409619867801666,
-0.14710696041584015,
0.07916318625211716,
0.2550015449523926,
-0.38006213307380676,
0.7123961448669434,
-0.46776941418647766,
0.9740104675292969,
-0.08364873379468918,
-0.3063833713531494,
1.2464914321899414,
0.4442301094532013,
-0.045814622193574905,
-0.14831562340259552,
0.001312193344347179,
0.5961461067199707,
-0.18852218985557556,
-0.3670805096626282,
0.09233330935239792,
-0.16460610926151276,
0.14521008729934692,
0.3551579415798187,
-0.1259024292230606,
0.2505674958229065,
0.1326266974210739,
-0.21023820340633392,
0.21372577548027039,
0.3048112988471985,
-0.023229079321026802,
0.007217868231236935,
-0.15122811496257782,
-0.16031920909881592,
-0.24206633865833282,
0.6924216151237488,
-0.6035600900650024,
0.2640484571456909,
0.4389033317565918,
-0.19958825409412384,
0.6572449803352356,
0.8494752049446106,
0.2262735366821289,
1.0465658903121948,
0.3233015537261963,
0.3215138614177704,
-0.3172614574432373,
0.6671000719070435,
-0.5041185021400452,
-0.17430610954761505,
0.2341807633638382,
-0.03932148963212967,
-0.07004900276660919,
0.10561478137969971,
0.05618409067392349,
-0.4248219132423401,
0.8532949090003967,
-0.5982161164283752,
-0.525499701499939,
-0.06965919584035873,
-0.8211259245872498,
-0.16338135302066803,
0.10970314592123032,
-1.3021767139434814,
0.1518343985080719,
0.16940166056156158,
0.18136721849441528,
0.3743857145309448,
0.014006595127284527,
0.42048344016075134,
0.08176440745592117,
0.07908035814762115,
-0.3951932191848755,
0.0742957666516304,
-0.4353584051132202,
0.13752099871635437,
0.19106321036815643,
0.0690409243106842,
0.30402234196662903,
0.09329992532730103,
-0.6935666799545288,
-0.519984781742096,
-0.39587780833244324,
0.7348007559776306,
0.5372049808502197,
0.5826238393783569,
-0.03589754179120064,
-0.20485427975654602,
-0.05633719637989998,
0.6142486333847046,
-0.4490145742893219,
0.25207510590553284,
0.283314973115921,
-0.2426004856824875,
-0.04402811452746391,
-0.17760124802589417,
-0.19479019939899445,
0.7433201670646667,
-0.36496198177337646,
0.012638675048947334,
-0.18584264814853668,
-0.18693186342716217,
-0.2199559360742569,
-0.20203979313373566,
-0.1281508505344391,
0.027150508016347885,
0.3507974445819855,
0.0018542235484346747,
-0.4752882122993469,
-0.10180263966321945,
0.11700154095888138,
-0.08640775829553604,
0.5404520034790039,
0.19945044815540314,
-0.08369359374046326,
-0.1697160303592682,
0.5560629367828369,
-0.19897785782814026,
-0.15173086524009705,
0.07610426098108292,
0.4276238977909088,
-0.4554040729999542,
0.22437551617622375,
-6.07867431640625,
0.529240608215332,
-0.08623287081718445,
-0.5133091807365417,
0.08886057883501053,
0.014152832329273224,
0.3938184380531311,
-0.18522143363952637,
0.14203914999961853,
0.031133165583014488,
0.527077317237854,
-0.2834315001964569,
0.025181667879223824,
-0.14369720220565796,
-0.0946226641535759,
0.09032852947711945,
-0.7437261939048767,
0.025035541504621506,
0.3528977036476135,
0.14954887330532074,
-0.2714938223361969,
-0.3933641314506531,
-0.16354157030582428,
0.0017205459298565984,
-0.00990850105881691,
0.2785232961177826,
-0.9755399823188782,
-0.21643659472465515,
0.0072020539082586765,
-0.3213490843772888,
-0.24887149035930634,
-0.1863764226436615,
-0.24757269024848938,
-0.2080909162759781,
0.1308971345424652,
0.1943412572145462,
0.05972667783498764,
0.2546510696411133,
0.34962061047554016,
0.14950460195541382,
0.3301910161972046,
0.0936419665813446,
-0.20615480840206146,
-0.28251299262046814,
-0.22182369232177734,
-0.04351406171917915,
-0.17158988118171692,
0.46413835883140564,
-0.16126590967178345,
0.4673161208629608,
-0.39089229702949524,
-0.22494977712631226,
0.13961070775985718,
0.321233332157135,
0.1482873260974884,
0.15607726573944092,
0.004305850714445114,
-0.09479616582393646,
-0.3709259033203125,
0.009550194256007671,
-0.04175734892487526,
-0.062297895550727844,
-0.032472386956214905,
-0.7860056161880493,
0.15665939450263977,
0.2968827486038208,
-0.527105450630188,
-0.02553974837064743,
0.3640684187412262,
-0.23116788268089294,
-0.293414831161499,
-0.4269246757030487,
-0.00562114967033267,
-0.834251880645752,
0.3809438645839691,
-0.739139974117279,
0.05618816986680031,
-0.07901688665151596,
0.22924266755580902,
-0.33276528120040894,
-0.07071131467819214,
-0.19882115721702576,
-0.05663399025797844,
-0.2563254237174988,
0.40313205122947693,
-0.5252552628517151,
-0.38069456815719604,
0.19951045513153076,
-0.12777069211006165,
0.2851054072380066,
0.048329856246709824,
-0.309249609708786,
0.007024128455668688,
0.817154586315155,
0.2893238663673401,
0.2722349166870117,
0.2560034394264221,
0.33174681663513184,
0.6243321299552917,
0.12576161324977875,
0.8350902199745178,
-0.710889458656311,
-0.6322067379951477,
-0.3595139980316162,
0.031065670773386955,
0.5460776090621948,
-0.6521952152252197,
0.46911269426345825,
0.7479848861694336,
-0.3399273753166199,
0.2428046613931656,
-0.053413908928632736,
0.027787428349256516,
0.04998033121228218,
0.7201256155967712,
-0.14953117072582245,
-0.06101752445101738,
0.08325603604316711,
0.6467957496643066,
-0.12036589533090591,
0.47075843811035156,
0.13291829824447632,
-0.3805195391178131,
0.4753061532974243,
0.43147605657577515,
-0.026102636009454727,
-0.2045390009880066,
0.5661612749099731,
-0.9045571088790894,
-0.49955952167510986,
0.3331681787967682,
0.01794157177209854,
-0.28689736127853394,
-0.02767181023955345,
0.2746064364910126,
-0.013619082048535347,
-0.47983816266059875,
0.1703062653541565,
0.512908935546875,
-0.3557725250720978,
-0.13258641958236694,
-0.3426004946231842,
-0.1835440695285797,
0.08028664439916611,
-0.169755756855011,
-0.15887930989265442,
0.09276960045099258,
-0.2222587615251541,
-0.2767656147480011,
-0.5652695894241333,
0.5401031970977783,
-0.32403042912483215,
0.09436992555856705,
0.383430153131485,
-0.9200361371040344,
-0.2555229961872101,
0.33596694469451904,
0.5419362783432007,
0.3189728856086731,
-0.9476035237312317,
0.5257378816604614,
-0.14216047525405884,
-0.7590283751487732,
0.2994993329048157,
-0.22386173903942108,
-0.47443902492523193,
0.2405211329460144,
-0.1751178354024887,
-0.020127994939684868,
0.24165794253349304,
0.13818715512752533,
-0.5029083490371704,
0.19767045974731445,
-0.1955362856388092,
-0.16958743333816528,
-0.2873063385486603,
-0.12545102834701538,
-0.23304295539855957,
0.05572323873639107,
0.5442013144493103,
-0.17583836615085602,
0.18326149880886078,
-0.16130231320858002,
0.04120839759707451,
0.557957112789154,
0.5542894601821899,
0.07750946283340454,
-0.41900187730789185,
-0.1916465312242508,
-0.4115999639034271,
0.5869391560554504,
0.17153318226337433,
0.6291608810424805,
0.06568119674921036,
0.029827658087015152,
0.10039638727903366,
0.03389464318752289,
0.19425594806671143,
0.30668574571609497,
-0.20890331268310547,
0.05985802784562111,
0.05472720041871071,
-0.1868356615304947,
0.3217545449733734,
0.6366354823112488,
0.05790397897362709,
-0.07863160222768784,
-0.17146189510822296,
-0.2008787989616394,
-0.19658978283405304,
-0.35042697191238403,
-0.7015249729156494,
0.022387001663446426,
0.2963330149650574,
0.1384619176387787,
-0.3388008177280426,
0.00529437605291605,
-0.3503010869026184,
-0.10255169123411179,
0.3630415201187134,
-0.039503663778305054,
0.0723029300570488,
-0.012819025665521622,
-0.4904308021068573,
-0.02366950921714306,
0.36450833082199097,
0.4345850348472595,
-0.5294561982154846,
0.11130116879940033,
-0.01880553737282753,
-0.20482772588729858,
-0.5260564088821411,
0.4025704264640808,
0.23339052498340607,
-0.5849121809005737,
-0.3763699531555176,
-0.1043073832988739,
-0.16933494806289673,
0.03215152025222778,
0.2009531557559967,
0.270272433757782,
0.354539692401886,
-0.07566183805465698,
0.05394795909523964,
-0.1972120851278305,
0.10125915706157684,
-0.13309907913208008,
-0.5569013953208923,
0.18934687972068787,
-0.2029450535774231,
-0.14517657458782196,
-0.6015545129776001,
0.22898846864700317,
0.8861449360847473,
0.8298601508140564,
0.7358056902885437,
-0.2772502303123474,
-0.3773696720600128,
-0.049671925604343414,
0.11411508917808533,
0.11842946708202362,
0.16811135411262512,
0.023025160655379295,
0.10874021053314209,
-0.3993239998817444,
-0.1293003410100937,
-0.47020119428634644,
-0.5649223923683167,
0.17577049136161804,
0.2787976861000061,
0.6282519698143005,
-0.516634464263916,
0.38764363527297974,
0.20955638587474823,
-0.13783109188079834,
0.13191145658493042,
-0.21408380568027496,
0.09338527917861938,
-0.08514431864023209,
0.4962947368621826,
-0.3160383403301239,
-0.4252227246761322,
0.41836002469062805,
-0.33889302611351013,
0.44211211800575256,
-0.44787031412124634,
-0.019355546683073044,
-0.5401560664176941,
0.2718299627304077,
-0.20186477899551392,
-0.6702843904495239,
-0.027127331122756004,
-0.5014028549194336,
-0.4698319733142853,
-0.029350781813263893,
-0.07743611931800842,
0.17054370045661926,
0.67229825258255,
0.1103133112192154,
-0.0746392086148262,
-0.49984025955200195,
0.7703244090080261,
0.5552518367767334,
-0.2575010657310486,
0.20946624875068665,
-0.14078308641910553,
0.19781865179538727,
0.39431145787239075,
-0.6744942665100098,
-0.09913201630115509,
-0.034079745411872864,
-0.04803459718823433,
0.10601139813661575,
-0.1136554628610611,
-0.46120983362197876,
0.2182888239622116,
-0.06008676439523697,
-0.1275940239429474,
0.40080559253692627,
0.369249552488327,
0.5498579144477844,
0.42244622111320496,
0.37783029675483704,
0.2969411015510559,
0.08932529389858246,
0.7907717227935791,
0.28149640560150146,
0.30289849638938904,
0.14210325479507446,
0.8485586643218994,
0.4032542407512665,
0.19153909385204315,
-0.09887319803237915,
0.21419154107570648,
0.18225888907909393,
0.23895153403282166,
0.17361222207546234,
-0.166082501411438,
0.05561015382409096,
0.23227158188819885,
0.48939579725265503,
0.103436678647995,
-0.12062957882881165,
-0.2595991790294647,
0.011118282563984394,
-0.08563924580812454,
-0.26399028301239014,
0.41830673813819885,
0.16442206501960754,
0.2667098939418793,
0.4886673390865326,
-0.32735782861709595,
-0.10627951472997665,
0.3575384318828583,
-0.2995818257331848,
0.20999865233898163,
0.47607019543647766,
-0.30724960565567017,
-0.9247676134109497,
0.16230031847953796,
-0.040001656860113144,
0.4544471800327301,
0.2560821771621704,
0.5859934091567993,
0.3019889295101166,
-0.20550519227981567,
0.22514811158180237,
0.2980755567550659,
0.1843128353357315,
0.03133205696940422,
-0.15570694208145142,
-0.1715131253004074,
-0.08140664547681808,
0.4571845829486847,
0.33061638474464417,
0.38267505168914795,
-0.13032473623752594,
0.14227861166000366,
0.0002986122271977365,
0.4158715009689331,
-0.2967175841331482,
-0.313150554895401,
-0.05461304634809494,
-0.7265275120735168,
-0.16479070484638214,
-0.40017402172088623,
-0.07902868837118149,
0.08269144594669342,
0.002869122661650181,
0.2561827301979065,
0.34711065888404846,
-0.8780896067619324,
0.13722684979438782,
0.059493500739336014,
0.07051585614681244,
-0.24665935337543488,
-0.09491655975580215,
0.05181831493973732,
0.3228134214878082,
0.1752559393644333,
-0.3446146845817566,
0.18176674842834473,
-0.1725226640701294,
-0.04704015702009201,
-0.443086177110672,
0.10477342456579208,
-0.2780512571334839,
0.006238143891096115,
-0.48446527123451233,
0.010335755534470081,
0.704632580280304,
0.4209829270839691,
-0.37092840671539307,
0.18095220625400543,
0.177094504237175,
0.568023681640625,
0.45215001702308655,
-0.3470098078250885,
-0.08975812047719955,
-0.2959522008895874,
0.07823031395673752,
-0.983609676361084,
0.45554083585739136,
0.1274975687265396,
-0.0827074646949768,
0.01284082978963852,
0.14872314035892487,
0.35849010944366455,
-1.1975950002670288,
0.5347810387611389,
0.03112649917602539,
-0.062438003718853,
-0.0661756694316864,
-0.1918674111366272,
-0.724705159664154,
-0.3423311412334442,
-0.17622599005699158,
0.0601409487426281,
-0.013067448511719704,
-0.22244472801685333,
0.18168707191944122,
-0.49181872606277466,
-0.08561432361602783,
-0.06972313672304153,
0.21636824309825897,
0.028805004432797432,
0.1464596539735794,
-0.4404051601886749,
-0.6904286742210388,
0.12923094630241394,
0.13818305730819702,
-0.5287463068962097,
-0.2206631749868393,
-0.023423949256539345,
-0.38920828700065613,
0.3346734941005707,
0.3758591413497925,
-0.2574853003025055,
0.2316202074289322,
-0.12015292048454285
] |
In vitro cytotoxicity testing has become an integral aspect of drug discovery because it is a convenient, costeffective, and predictive means of characterizing the toxic potential of new chemical entities. The early and routine implementation of this testing is testament to its prognostic importance for humans. Although a plethora of assay chemistries and methods exist for 96-well formats, few are practical and sufficiently sensitive enough for application in high throughput screening (HTS). Here we briefly describe a handful of the currently most robust and validated HTS assays for accurate and efficient assessment of cytotoxic risk. We also provide guidance for successful HTS implementation and discuss unique merits and detractions inherent in each method. Lastly, we discuss the advantages of combining specific HTS compatible assays into multi-parametric, same-well formats. | [
0.006333843804895878,
0.0007003534119576216,
-0.012291571125388145,
0.012910386547446251,
-0.00017383648082613945,
0.0018679453060030937,
0.009458910673856735,
-0.0018797880038619041,
-0.012197436764836311,
-0.01695168763399124,
-0.00805399939417839,
0.0010010073892772198,
-0.013378791511058807,
0.02182524837553501,
0.0050575016066432,
-0.014372273348271847,
-0.004836730659008026,
0.011256443336606026,
0.001286735525354743,
-0.002093348652124405,
-0.003783242776989937,
-0.015209817327558994,
0.010260740295052528,
-0.011870981194078922,
-0.0012154215946793556,
0.0064422497525811195,
0.02868654765188694,
-0.021768702194094658,
-0.012811960652470589,
-0.002834887709468603,
-0.00958128459751606,
-0.014562120661139488,
0.04101119562983513,
-0.024587351828813553,
0.002498835790902376,
-0.008759250864386559,
-0.0004878619220107794,
0.018946100026369095,
0.021452834829688072,
-0.002696942538022995,
-0.002976909978315234,
-0.006802110001444817,
0.004544893745332956,
0.014955618418753147,
-0.0032325093634426594,
0.008843354880809784,
-0.0024266024120151997,
0.005476056598126888,
-0.0034615069162100554,
0.008503729477524757,
-0.008969311602413654,
0.010463699698448181,
-0.0012469494249671698,
0.005139121785759926,
-0.006613974925130606,
-0.025281429290771484,
0.019411297515034676,
-0.014368540607392788,
-0.007857410237193108,
-0.0160246379673481,
0.0011783054796978831,
-0.006919813342392445,
0.011893613263964653,
0.009727046824991703,
0.0021228790283203125,
-0.06715738028287888,
-0.007178960368037224,
0.0025003599002957344,
0.022628124803304672,
0.01164073497056961,
-0.015016266144812107,
0.01303590927273035,
-0.00876015517860651,
0.015079360455274582,
0.01236062590032816,
0.006046172231435776,
0.0012960166204720736,
-0.005437709856778383,
0.022190719842910767,
-0.008032536134123802,
0.0034269136376678944,
-0.003949051722884178,
0.007790263742208481,
0.0016443660715594888,
0.006323834881186485,
-0.004660576581954956,
-0.006706157699227333,
-0.007252214010804892,
0.013156483881175518,
-0.0253515113145113,
-0.009038714691996574,
-0.012933284044265747,
-0.007740426808595657,
-0.017634112387895584,
-0.007460868917405605,
0.01323013287037611,
0.016829688102006912,
-0.012932595796883106,
0.01814604178071022,
-0.019881103187799454,
-0.0072797369211912155,
0.013170893304049969,
0.020951921120285988,
0.014677047729492188,
0.0006801466806791723,
0.008762981742620468,
0.00404233206063509,
0.0028075824957340956,
-0.02373114600777626,
0.002948786597698927,
0.007355139125138521,
0.011693445965647697,
-0.005956882145255804,
0.010237962938845158,
0.010214054025709629,
-0.005845915991812944,
-0.002591572469100356,
0.004370073322206736,
0.006011985708028078,
-0.0036123497411608696,
-0.0009864617604762316,
0.0006894245743751526,
0.013079375959932804,
-0.017976097762584686,
0.0041327448561787605,
-0.0014986125752329826,
-0.011631866917014122,
-0.0031986674293875694,
-0.0019226303556934,
-0.009856143966317177,
-0.007516087032854557,
0.002778242342174053,
0.02023543044924736,
-0.04466564953327179,
-0.0024243537336587906,
-0.0018658493645489216,
0.00034298026002943516,
0.015262056142091751,
-0.0028090006671845913,
-0.007091744337230921,
-0.0028295607771724463,
0.007194051053375006,
-0.003920617513358593,
0.009107767604291439,
-0.008262800052762032,
0.0018567563965916634,
-0.011493310332298279,
-0.004388758912682533,
0.005593680310994387,
-0.024468805640935898,
-0.0011796178296208382,
-0.01415420975536108,
-0.029998786747455597,
-0.020258264616131783,
0.014293120242655277,
-0.005281542427837849,
-0.002591619733721018,
-0.010893303900957108,
-0.015002002008259296,
-0.03635019809007645,
0.04325966536998749,
-0.023529674857854843,
0.006631346885114908,
0.007942089810967445,
-0.02010529674589634,
0.01847221702337265,
-0.014256574213504791,
0.006534948013722897,
0.005874238442629576,
0.0010020920308306813,
-0.011012764647603035,
0.00648313295096159,
0.003956250846385956,
0.00843781791627407,
-0.008446544408798218,
-0.007299885619431734,
0.016450125724077225,
0.005593742709606886,
-0.018573235720396042,
0.06715558469295502,
0.009935084730386734,
0.024758653715252876,
-0.022655073553323746,
-0.0037483894266188145,
0.0260651595890522,
0.0005475807702168822,
0.013712798245251179,
-0.00766737712547183,
-0.020082300528883934,
-0.0035862228833138943,
-0.007279612123966217,
-0.004219283815473318,
0.012337515130639076,
0.004473591223359108,
0.026326743885874748,
0.0027713398449122906,
0.0052814846858382225,
-0.00019643735140562057,
0.01561774406582117,
-0.0030074836686253548,
0.00014176382683217525,
0.007636595517396927,
0.006444522179663181,
-0.006037021055817604,
-0.02386825531721115,
0.0034227450378239155,
0.005397170782089233,
-0.026786677539348602,
0.022033456712961197,
0.00731203006580472,
0.014209657907485962,
0.0041997069492936134,
0.016787569969892502,
-0.011436228640377522,
-0.001710031647235155,
0.005498935002833605,
0.0025313799269497395,
-0.00440670270472765,
-0.01687730848789215,
-0.016752546653151512,
0.00211861589923501,
-0.006805461831390858,
0.017155563458800316,
0.006435496732592583,
0.011278852820396423,
-0.000881043728441,
0.006214283872395754,
0.008427219465374947,
-0.008961651474237442,
0.0031200763769447803,
-0.004885112401098013,
-0.007843229919672012,
-0.009190978482365608,
0.007052340544760227,
0.002446838654577732,
-0.010157516226172447,
0.009502025321125984,
0.00039998069405555725,
0.010188765823841095,
-0.013914338313043118,
0.0016840448370203376,
-0.014290005899965763,
0.02617909386754036,
-0.005734588950872421,
-0.016805829480290413,
0.006369283422827721,
0.010181952267885208,
-0.0018877454567700624,
-0.031407006084918976,
-0.00447990745306015,
0.0014451084425672889,
0.0022699625696986914,
0.0063805351965129375,
0.000005712732672691345,
-0.015353788621723652,
-0.0029163314029574394,
0.022928953170776367,
0.007562084123492241,
0.02401047572493553,
-0.010896444320678711,
0.005977202206850052,
0.004093772266060114,
0.0019326056353747845,
-0.005107496865093708,
0.009708327241241932,
-0.006326470989733934,
0.007132044993340969,
-0.005736975930631161,
0.03135817497968674,
-0.0022844281047582626,
0.0021333738695830107,
-0.00401747552677989,
-0.007016549818217754,
-0.08142969012260437,
-0.010052327066659927,
-0.002757032634690404,
0.009727979078888893,
0.013791613280773163,
-0.013462933711707592,
-0.0036068884655833244,
0.011881169863045216,
-0.0008607248309999704,
-0.0010469378903508186,
0.00047759804874658585,
0.012941510416567326,
-0.006865372881293297,
-0.001162051921710372,
0.015755798667669296,
-0.008397698402404785,
0.0022529568523168564,
-0.018966415897011757,
-0.011248402297496796,
0.002270324155688286,
-0.0132299130782485,
-0.0182447899132967,
0.014953910373151302,
0.011507533490657806,
0.019335737451910973,
-0.008128806948661804,
0.011925967410206795,
0.00044071953743696213,
0.003303297096863389,
0.004878402687609196,
0.012493518181145191,
0.010385029949247837,
0.0008587120100855827,
0.001048387261107564,
0.00942029245197773,
0.012876677326858044,
-0.009870857000350952,
0.01552010141313076,
0.0024091012310236692,
0.016404692083597183,
-0.017161734402179718,
0.007359161972999573,
-0.005879286676645279,
-0.0013729250058531761,
-0.006514180917292833,
-0.003759079845622182,
-0.019272252917289734,
0.01737036556005478,
0.01829008013010025,
-0.004257263150066137,
0.013227466493844986,
0.002936585107818246,
0.026634356006979942,
0.01753159984946251,
-0.012781212106347084,
-0.011610138230025768,
-0.006945021450519562,
0.02735319547355175,
-0.015947451815009117,
-0.005206701345741749,
0.019443096593022346,
-0.018809111788868904,
-0.05739974603056908,
0.02099364995956421,
-0.009966141544282436,
-0.000647558132186532,
-0.0024312161840498447,
0.002598552033305168,
-0.010263892821967602,
-0.001416548271663487,
0.002519279718399048,
-0.011442659422755241,
-0.016979340463876724,
0.006660897750407457,
-0.011721579357981682,
-0.009278851561248302,
-0.014312470331788063,
0.0029667839407920837,
0.009811140596866608,
-0.010226656682789326,
0.0116354301571846,
0.008980786427855492,
-0.008582561276853085,
0.004024690017104149,
0.0001429577823728323,
-0.005455459468066692,
0.005170338787138462,
0.02424006536602974,
0.009894544258713722,
-0.013387813232839108,
0.016509370878338814,
-0.019685998558998108,
-0.003801575396209955,
0.006467604544013739,
-0.004164592362940311,
-0.019458718597888947,
0.013604531064629555,
0.01427486352622509,
0.022956430912017822,
0.009733019396662712,
0.0004585282877087593,
-0.001389251439832151,
0.016950860619544983,
-0.012656675651669502,
-0.037130266427993774,
0.013989465311169624,
-0.002789601683616638,
-0.006044975481927395,
0.0006864757742732763,
-0.009125212207436562,
0.00817062146961689,
-0.03097047284245491,
-0.009018633514642715,
0.005133930128067732,
0.01326916366815567,
-0.0023503524716943502,
-0.0036084321327507496,
-0.012587732635438442,
0.07227548956871033,
0.0033759959042072296,
0.0006058240542188287,
-0.010033529251813889,
-0.0011259280145168304,
-0.016939595341682434,
0.013089073821902275,
0.009226473048329353,
0.03651276230812073,
-0.030494412407279015,
0.012270726263523102,
-0.00016503455117344856,
-0.02302372083067894,
-0.022071227431297302,
-0.0006269524456001818,
-0.00944515597075224,
0.017337171360850334,
-0.0064261434599757195,
-0.01010556984692812,
0.00013365689665079117,
0.024448826909065247,
-0.003944768570363522,
0.00855790264904499,
0.000923293991945684,
0.0025807644706219435,
-0.02502896636724472,
-0.018154850229620934,
-0.013825228437781334,
-0.02184491977095604,
0.0033212658017873764,
0.005930834449827671,
0.00895368866622448,
-0.003316151909530163,
-0.007641041185706854,
0.014820041134953499,
0.013926832005381584,
0.02707855962216854,
-0.0011781121138483286,
-0.021048108115792274,
-0.008065039291977882,
0.01353039126843214,
-0.018590018153190613,
-0.01636311411857605,
0.01752651110291481,
0.005274256691336632,
0.009567920118570328,
-0.009821212850511074,
-0.003914958797395229,
-0.004989602603018284,
0.004641013219952583,
-0.01776839606463909,
0.0004635099321603775,
0.012938437983393669,
-0.007826593704521656,
0.007860426791012287,
0.0031502617057412863,
-0.027306843549013138,
0.0009629898704588413,
-0.007438051514327526,
-0.03669937700033188,
-0.0015745155978947878,
-0.02688666433095932,
-0.016316138207912445,
0.000715476693585515,
0.009182203561067581,
-0.009070278145372868,
-0.010087573900818825,
0.004270956851541996,
0.010347310453653336,
0.006719693075865507,
-0.010429405607283115,
-0.012149443849921227,
-0.004210984334349632,
-0.01946190930902958,
-0.027832448482513428,
0.00041926722042262554,
0.0009284426923841238,
-0.009515605866909027,
0.028567012399435043,
-0.023786306381225586,
-0.020386813208460808,
0.004482086282223463,
0.013832835480570793,
-0.031541161239147186,
0.006935285869985819,
0.011128846555948257,
-0.0031984641682356596,
-0.0748768150806427,
-0.02137458696961403,
0.005530002061277628,
-0.005240468308329582,
-0.003581289667636156,
0.002552127931267023,
-0.004735641181468964,
-0.001466706395149231,
0.010393038392066956,
-0.0037881573662161827,
0.018275180831551552,
-0.008315155282616615,
0.013164271600544453,
0.023584986105561256,
0.0093297827988863,
0.012800327502191067,
-0.04122382402420044,
-0.006441745441406965,
-0.027219455689191818,
-0.006735644303262234,
-0.034702226519584656,
-0.0017989259213209152,
-0.027330860495567322,
-0.0017548513133078814,
0.0041258796118199825,
-0.0814329981803894,
0.020774036645889282,
-0.013480898924171925,
-0.02879498526453972,
-0.00171465496532619,
-0.016001593321561813,
0.006978663615882397,
-0.01337719988077879,
0.0020150896161794662,
-0.01335170865058899,
-0.009996536187827587,
-0.0059583066031336784,
-0.03603743389248848,
0.007530351169407368,
0.010440157726407051,
-0.002951577305793762,
0.008392004296183586,
0.0038464597892016172,
0.02046610414981842,
0.0038582980632781982,
0.014877681620419025,
0.03662177175283432,
-0.005286111030727625,
-0.0036064842715859413,
-0.012654371559619904,
-0.014267565682530403,
-0.002294419799000025,
0.014957203529775143,
0.0054550557397305965,
0.023605335503816605,
-0.0038803545758128166,
-0.01572321355342865,
-0.007295222021639347,
-0.013934580609202385,
0.01774885319173336,
-0.012410289607942104,
0.01688753068447113,
-0.0061993650160729885,
0.016525592654943466,
-0.0018185190856456757,
-0.00848808977752924,
0.010074140504002571,
0.007483241613954306,
-0.009712289087474346,
0.019756261259317398,
-0.0050155483186244965,
0.0028457744047045708,
-0.0025473074056208134,
0.002475761342793703,
0.015524918213486671,
0.0034726099111139774,
-0.003889098297804594,
0.007358415052294731,
-0.0016316487453877926,
-0.00315522076562047,
-0.003143034875392914,
-0.006345130503177643,
0.007669122889637947,
-0.029537808150053024,
0.016142887994647026,
-0.009877655655145645,
0.0021271095611155033,
-0.004373206291347742,
0.0721147358417511,
-0.008848115801811218,
0.006693192757666111,
-0.024220705032348633,
-0.00442943349480629,
-0.001443122630007565,
0.006524523254483938,
-0.012992076575756073,
-0.002134953159838915,
-0.0014032595790922642,
-0.006398618686944246,
0.0003981553018093109,
0.013563079759478569,
0.006796884350478649,
-0.005659850314259529,
0.011796915903687477,
-0.021871931850910187,
0.010386360809206963,
0.014130106195807457,
0.026953689754009247,
0.006987950764596462,
-0.013370404951274395,
0.0030961092561483383,
-0.039013609290122986,
0.021362382918596268,
-0.000003380700945854187,
-0.013572056777775288,
-0.006246070843189955,
-0.011863062158226967,
-0.012003101408481598,
-0.007526921574026346,
0.007957304827868938,
0.0008701923070475459,
0.021733814850449562,
0.012109920382499695,
0.004256824497133493,
-0.002127287443727255,
-0.0006612890283577144,
0.015590187162160873,
0.015547946095466614,
0.02159990929067135,
0.004924573004245758,
-0.0018457651603966951,
-0.007825223729014397,
0.021898601204156876,
0.0016053305007517338,
0.0020197771955281496,
-0.00804087519645691,
-0.0005647949874401093,
0.011685054749250412,
0.021269455552101135,
0.0031319845002144575,
-0.007353203371167183,
-0.02783023938536644,
-0.007283416576683521,
-0.0013779007131233811,
0.0003445083275437355,
0.014462428167462349,
0.014022154733538628,
-0.0032979906536638737,
0.018320567905902863,
-0.01630532741546631,
-0.008524730801582336,
-0.008545929566025734,
0.029457980766892433,
0.008702097460627556,
-0.015063641592860222,
-0.008760903961956501,
0.002511064987629652,
0.01444888673722744,
-0.008030110970139503,
0.013746073469519615,
0.0039879195392131805,
-0.009077916853129864,
0.008172375150024891,
0.024088479578495026,
0.0166181568056345,
-0.0006634872406721115,
0.007387081161141396,
0.004259892739355564,
-0.01681375503540039,
-0.007126569747924805,
-0.007457204628735781,
-0.00985661894083023,
-0.01173401065170765,
0.0017155269160866737,
0.011862548068165779,
0.0041654338128864765,
-0.0009083331096917391,
0.009123941883444786,
0.0064600068144500256,
-0.0041630868799984455,
-0.005185182671993971,
0.00471393670886755,
0.008176669478416443,
0.03426949307322502,
0.011353115551173687,
0.007329446263611317,
0.0010832472471520305,
-0.003764935303479433,
0.016950398683547974,
0.03628259152173996,
-0.014390519820153713,
0.01394303236156702,
-0.011538938619196415,
-0.004768926650285721,
0.01185544952750206,
-0.003552402136847377,
0.014069871045649052,
0.020736511796712875,
-0.008386969566345215,
0.002092986134812236,
0.002396731171756983,
-0.0038792560808360577,
-0.016486618667840958,
0.007992594502866268,
0.0018630141858011484,
0.00032671750523149967,
0.0024853928480297327,
-0.007788498420268297,
-0.005414709448814392,
0.0025973340962082148,
-0.025161899626255035,
0.0051374491304159164,
0.04339599609375,
-0.010616103187203407,
-0.008468285202980042,
0.003302504774183035,
-0.008933518081903458,
0.008730561472475529,
0.011397252790629864,
-0.0036210392136126757,
0.01792721077799797,
-0.0070902518928050995,
0.008980614133179188,
-0.005423577968031168,
-0.011032519862055779,
0.010469437576830387,
-0.02968544326722622,
0.0012515322305262089,
-0.015637952834367752,
0.00364093529060483,
-0.009359382092952728,
-0.006814887747168541,
0.009042643010616302,
-0.014237345196306705,
-0.003987913019955158,
0.016084056347608566,
0.006940224673599005,
0.0016709568444639444,
0.011950628831982613,
0.016250979155302048,
-0.017291706055402756,
-0.0071940007619559765,
0.003284906968474388,
0.026469996199011803,
0.011308690533041954,
0.006869984790682793,
-0.03223995864391327,
-0.001695200800895691,
-0.001481947023421526,
-0.02255210652947426,
0.01994474232196808,
0.008961284533143044,
-0.004045181907713413,
0.043045490980148315,
-0.0010722177103161812,
0.026484036818146706,
0.007281211204826832,
-0.0029364917427301407,
0.020500613376498222,
0.0032891803421080112,
0.0073499418795108795,
0.014953612349927425,
-0.01804112270474434,
-0.008168390952050686,
-0.014483550563454628,
0.007640180643647909,
-0.005440873559564352,
-0.012405052781105042,
0.004498873837292194,
-0.007448921445757151,
-0.009469643235206604,
-0.008355753496289253,
0.001085205003619194,
-0.0015922598540782928,
-0.009899011813104153,
0.0006231935694813728,
0.012904198840260506,
0.013295664452016354,
-0.02606750652194023,
-0.004614628851413727,
-0.01957465149462223,
0.011571399867534637,
0.010003895498812199,
-0.011299910955131054,
0.008905583061277866,
-0.04499194771051407,
0.01751590520143509,
0.003711082972586155,
-0.008781411685049534,
-0.017214855179190636
] | [
0.4997974932193756,
0.3174789845943451,
-0.001292240689508617,
0.14778102934360504,
0.12124395370483398,
-0.1822749376296997,
-0.1369093954563141,
-0.46587973833084106,
0.45348677039146423,
-0.43073105812072754,
-0.14071163535118103,
0.6050835847854614,
-0.07260128110647202,
0.23210085928440094,
-0.2300209105014801,
0.46676743030548096,
0.5769087076187134,
0.3367742896080017,
0.26233798265457153,
-0.4843910336494446,
-0.436675488948822,
-0.19331243634223938,
-0.005605813581496477,
-0.057684045284986496,
0.06932646036148071,
0.08778297901153564,
0.28773072361946106,
-0.22567804157733917,
-0.35376977920532227,
-0.022115077823400497,
-0.002633188385516405,
0.2740382254123688,
-0.38827961683273315,
-0.5206132531166077,
0.07279253005981445,
0.4737454652786255,
-0.4236765205860138,
0.016273895278573036,
-0.19473259150981903,
-0.45217037200927734,
-0.12256325781345367,
0.09012135863304138,
0.1903088241815567,
0.4955720603466034,
-0.49525490403175354,
-0.16214515268802643,
-1.5600546598434448,
0.38865575194358826,
-0.6178487539291382,
0.3123580515384674,
0.24056538939476013,
-0.050600044429302216,
-0.102088563144207,
0.18665307760238647,
0.0727580115199089,
0.16676867008209229,
-0.4067768156528473,
-0.11535592377185822,
0.26597750186920166,
-0.1984029859304428,
0.1770479679107666,
-0.05918898433446884,
-0.17343999445438385,
0.24958214163780212,
0.33666354417800903,
-0.11245539784431458,
0.29087746143341064,
-0.27523964643478394,
-0.48136067390441895,
-0.07700598984956741,
0.25484609603881836,
-0.2903984785079956,
-0.1468830108642578,
0.20065490901470184,
-0.44545865058898926,
0.09998301416635513,
-0.05402321368455887,
-0.07285419851541519,
0.27502763271331787,
-0.011658484116196632,
0.2660752832889557,
-0.034606073051691055,
-0.19384533166885376,
-0.015660442411899567,
0.7803091406822205,
0.08745653182268143,
0.11404642462730408,
0.836658239364624,
-0.6077147722244263,
0.1217561662197113,
0.352065771818161,
-0.27970483899116516,
-0.0830158144235611,
-0.05974776670336723,
0.17415837943553925,
0.3653036653995514,
0.2609429955482483,
-0.1768469661474228,
0.0015317280776798725,
0.4170433580875397,
0.012534958310425282,
-0.1139780730009079,
0.05156557261943817,
-0.19788384437561035,
-0.16411781311035156,
-0.27018457651138306,
-0.44971519708633423,
-0.4325661063194275,
-0.31780463457107544,
0.3617953062057495,
-0.3471424877643585,
0.7537294626235962,
0.007067433558404446,
0.18863268196582794,
-0.8956916928291321,
-0.017307991161942482,
0.17208077013492584,
0.20656605064868927,
0.09739260375499725,
0.06824609637260437,
-0.18635381758213043,
1.153268575668335,
-0.20620699226856232,
0.21960647404193878,
0.023766392841935158,
0.03729139640927315,
0.7357587218284607,
0.6606494188308716,
-0.288875937461853,
0.1880885660648346,
-0.07306788861751556,
0.6137311458587646,
0.22367016971111298,
-0.1926366239786148,
-0.24022457003593445,
-0.001306944410316646,
0.23039497435092926,
-0.14043840765953064,
0.27029287815093994,
0.10090934485197067,
-0.5682030320167542,
-0.9983425736427307,
0.005820964928716421,
0.24899376928806305,
0.03121805377304554,
-0.21791712939739227,
0.10730086266994476,
-0.0802152007818222,
-0.45622605085372925,
0.22603577375411987,
-0.033870309591293335,
0.2892795205116272,
-0.38383692502975464,
-0.022364001721143723,
-0.08184334635734558,
0.6473070979118347,
-0.2917889952659607,
-0.3174362778663635,
0.05617547407746315,
0.13518890738487244,
-0.01809469424188137,
-0.29607918858528137,
-0.44973206520080566,
-0.31354600191116333,
0.20578141510486603,
-0.5801065564155579,
0.08680801838636398,
0.5555779337882996,
-0.1467737853527069,
-0.06363285332918167,
-0.09189632534980774,
-0.3146789073944092,
0.08875296264886856,
-0.435270220041275,
-0.07673385739326477,
-0.19044974446296692,
0.5718364119529724,
0.26831305027008057,
0.46703267097473145,
0.17089276015758514,
-0.6267601847648621,
0.13604196906089783,
0.06080811470746994,
-0.2818220853805542,
0.06718337535858154,
0.07378504425287247,
0.737455427646637,
-0.05571461096405983,
-0.297063410282135,
-0.0898272693157196,
-0.1375001221895218,
-0.3069648742675781,
0.38220199942588806,
-1.019516110420227,
1.3437995910644531,
0.08261924237012863,
0.1628979742527008,
0.9307407140731812,
-0.49691516160964966,
-0.498733788728714,
0.0686185210943222,
0.6281852722167969,
0.25546175241470337,
-0.42900529503822327,
-0.9886974692344666,
-0.3893571197986603,
0.41313669085502625,
-0.49031347036361694,
-0.25418367981910706,
0.06684408336877823,
0.5526689291000366,
-0.18839803338050842,
0.02945016697049141,
-0.2465433031320572,
-0.159263014793396,
0.0020731305703520775,
-0.2749975323677063,
0.5476175546646118,
0.3032445013523102,
-0.045570891350507736,
0.43745818734169006,
-0.4222511649131775,
0.6764713525772095,
0.40150028467178345,
0.25962164998054504,
0.4477575123310089,
0.23328587412834167,
-0.040177907794713974,
0.9075950980186462,
-0.5354052782058716,
0.4593185782432556,
-0.2229038029909134,
0.597375750541687,
-0.5767403841018677,
-0.21375772356987,
-0.039518002420663834,
0.14667026698589325,
-0.10908622294664383,
-0.0215382631868124,
0.17074182629585266,
-0.45481035113334656,
0.044700827449560165,
-0.5491872429847717,
0.3156213164329529,
0.06613282859325409,
-0.23632343113422394,
-0.0006066406494937837,
0.10399769246578217,
-0.5128413438796997,
-0.04838591814041138,
0.1735549122095108,
0.311024010181427,
0.06904929131269455,
-0.886570394039154,
0.40507784485816956,
-0.23932358622550964,
-0.06670914590358734,
-0.543796956539154,
-0.23583804070949554,
-0.25218409299850464,
-0.26724159717559814,
0.007145688869059086,
0.1165180504322052,
0.15272574126720428,
0.008042213506996632,
-0.4618054926395416,
-0.4003794193267822,
-0.7144556641578674,
0.5808397531509399,
0.6045008301734924,
0.4946081042289734,
0.3965105712413788,
-0.2739589512348175,
0.046673599630594254,
-0.2386990785598755,
-0.32509729266166687,
-0.297990083694458,
0.3929225504398346,
-0.28094181418418884,
-0.011573459021747112,
0.28520467877388,
0.532200276851654,
0.1334657222032547,
-0.45107415318489075,
-0.27646780014038086,
-0.12782244384288788,
0.08827844262123108,
-0.8792641162872314,
-0.18503467738628387,
-0.010894210077822208,
-0.3219069838523865,
0.22154124081134796,
-0.31303417682647705,
-0.47109687328338623,
0.4828037917613983,
-0.17843055725097656,
-0.07518135011196136,
0.5811718106269836,
0.15405209362506866,
-0.02003001607954502,
-0.00807696208357811,
0.19118596613407135,
-0.24770498275756836,
-0.05159590393304825,
0.1818709820508957,
-0.42313140630722046,
0.09601649641990662,
-0.10004616528749466,
-6.05095911026001,
-0.10174909979104996,
-0.25166329741477966,
0.2236073911190033,
0.18280602991580963,
0.04901085048913956,
0.6963443756103516,
-0.13485082983970642,
-0.026458727195858955,
-0.01586983911693096,
-0.160248801112175,
0.357194185256958,
0.0019833077676594257,
0.268379807472229,
0.32759207487106323,
0.026301566511392593,
0.1104588434100151,
-0.25049707293510437,
0.321118026971817,
0.08179100602865219,
0.16721537709236145,
-0.04265046492218971,
0.07412925362586975,
0.8446427583694458,
0.14458352327346802,
-0.06384988129138947,
-0.7780874371528625,
0.3139868974685669,
-0.2678571343421936,
-0.04209534451365471,
0.005839033983647823,
-0.6124045848846436,
-0.4036349356174469,
-0.24895988404750824,
0.1527107059955597,
0.3403159976005554,
0.4610472619533539,
0.01658622734248638,
0.037233561277389526,
-0.5998218059539795,
0.33578646183013916,
0.22028100490570068,
-0.22365199029445648,
-0.045711494982242584,
0.2840474843978882,
-0.40954065322875977,
0.19030435383319855,
0.36767470836639404,
-0.14310197532176971,
0.6274749040603638,
-0.21224582195281982,
-0.10833574831485748,
0.6808775663375854,
0.11343304067850113,
0.06629370152950287,
-0.8856958150863647,
-0.062216248363256454,
0.23113606870174408,
0.1751842051744461,
0.11784029006958008,
-0.5310921669006348,
-0.6405231952667236,
-0.16745302081108093,
-0.7038150429725647,
-0.13973022997379303,
0.21829548478126526,
-0.3141593635082245,
-0.7703713178634644,
0.12420451641082764,
0.20674578845500946,
-0.4867721498012543,
0.6381419897079468,
0.517520010471344,
-0.4055544137954712,
0.55766761302948,
-0.012004951015114784,
0.4600456953048706,
0.05832800641655922,
-0.07688897848129272,
0.6015183925628662,
-0.47245946526527405,
-0.16838596761226654,
0.029277080669999123,
-0.2495516985654831,
-0.005943564232438803,
-0.5886393189430237,
-0.16210971772670746,
0.07637356221675873,
-0.15435604751110077,
-0.14782240986824036,
0.8097503185272217,
-0.2466646283864975,
0.5618981122970581,
0.5357432961463928,
0.37587523460388184,
0.5509877800941467,
0.3779374361038208,
0.683952808380127,
0.3230586349964142,
0.1515590250492096,
0.5881943106651306,
0.4057486057281494,
-0.37533921003341675,
-0.9233264327049255,
-0.07658953964710236,
-0.2090945541858673,
-0.44209960103034973,
-0.10592101514339447,
0.4449003338813782,
-0.7775935530662537,
-0.2885512113571167,
0.3332368731498718,
-0.16773492097854614,
0.25975072383880615,
0.263240784406662,
-0.026156606152653694,
-0.24498672783374786,
0.09033948183059692,
0.4684668183326721,
-0.31476813554763794,
0.3204464614391327,
0.1853177845478058,
-0.42856505513191223,
0.5242605805397034,
0.20682929456233978,
-0.46932944655418396,
0.3787792921066284,
1.0131763219833374,
-0.4254170060157776,
-0.25712546706199646,
0.21937604248523712,
0.3385796546936035,
-0.4090394973754883,
0.16422665119171143,
-0.02698369137942791,
-0.11265332251787186,
-0.29231923818588257,
0.10430167615413666,
-0.1994374394416809,
-0.3070183992385864,
0.6035968661308289,
-0.32117047905921936,
0.28170204162597656,
0.14485196769237518,
0.17402119934558868,
-0.17770090699195862,
-0.10380253195762634,
0.46333569288253784,
0.030148319900035858,
0.0119511429220438,
-0.2738795876502991,
-0.017859281972050667,
-0.031420931220054626,
-0.2600669264793396,
-0.09190908819437027,
-0.10962661355733871,
0.5684140920639038,
0.07942137122154236,
0.42169633507728577,
-0.31470558047294617,
0.16749198734760284,
0.2166626751422882,
-1.210937261581421,
-0.02497592754662037,
-0.1437813639640808,
-0.10941747575998306,
-0.3300565183162689,
0.433729350566864,
-0.44754084944725037,
0.36130785942077637,
-0.5147792100906372,
-0.3629402816295624,
-0.30828413367271423,
-0.24795828759670258,
0.10263567417860031,
-0.05691801384091377,
-0.028548842296004295,
0.3610689043998718,
-0.11076627671718597,
-0.35251104831695557,
0.2557354271411896,
-0.9833984375,
-0.19343218207359314,
0.1033301055431366,
0.8342399597167969,
-0.06300515681505203,
-0.11747346818447113,
-0.18107637763023376,
-0.07108467817306519,
-0.037982333451509476,
0.07730183750391006,
0.34316128492355347,
0.48563727736473083,
0.1808224618434906,
-0.23718500137329102,
-0.4057469367980957,
0.08796782791614532,
0.464189350605011,
-0.13871274888515472,
-0.291678249835968,
0.38363561034202576,
0.23006615042686462,
-0.3328315019607544,
0.04792149364948273,
0.6325312256813049,
-0.07640696316957474,
-0.026603493839502335,
0.1910468339920044,
-0.05643974244594574,
-0.24631190299987793,
-0.3195544481277466,
-0.3815193772315979,
-0.11405079811811447,
0.2380155473947525,
-0.363557368516922,
-0.3456399738788605,
0.18781644105911255,
0.16232885420322418,
-0.20366327464580536,
0.44291141629219055,
0.4185965657234192,
-0.12722645699977875,
-0.27931785583496094,
0.2987181544303894,
-0.4762425422668457,
-0.2501063048839569,
0.39294353127479553,
-0.4194245934486389,
-0.2763368487358093,
0.004116230644285679,
-0.5704153776168823,
0.0863288938999176,
0.07666998356580734,
0.05788243189454079,
0.011049151420593262,
-0.19936227798461914,
0.03958166390657425,
0.6545146107673645,
-0.6043729782104492,
-0.23565882444381714,
0.03950604796409607,
0.24111466109752655,
-0.29977908730506897,
0.08385884761810303,
-0.20111677050590515,
0.34383270144462585,
0.4711369574069977,
-0.42494916915893555,
-0.7772002220153809,
-0.32885023951530457,
0.3119380474090576,
0.16508899629116058,
0.004119428806006908,
0.21681906282901764,
0.8709331750869751,
-0.05150807276368141,
-0.13500875234603882,
-0.27356404066085815,
0.008448034524917603,
0.3769215941429138,
-0.1825820356607437,
-0.5271948575973511,
-0.7399651408195496,
-0.520313560962677,
0.686450183391571,
-0.03763369098305702,
-0.6294514536857605,
-0.9146420359611511,
0.1764879673719406,
-0.4846639931201935,
-0.033925365656614304,
-0.014348538592457771,
0.6654547452926636,
0.5869256258010864,
0.29520222544670105,
0.1874062716960907,
-0.2945442199707031,
0.12401982396841049,
-0.23932433128356934,
0.35192084312438965,
-0.18519842624664307,
-0.49305030703544617,
0.2616157531738281,
-0.4050283432006836,
-0.000547801551874727,
-0.4359232783317566,
0.08399452269077301,
-0.3553043007850647,
0.1157708689570427,
-0.30720120668411255,
0.09119817614555359,
0.36460766196250916,
-0.6998972296714783,
-0.10174022614955902,
-0.12716332077980042,
0.0006373826181516051,
0.6212679147720337,
0.22160594165325165,
0.20991532504558563,
-0.2859950363636017,
-0.33531075716018677,
0.33359238505363464,
0.8836666345596313,
-1.024322509765625,
0.5965563058853149,
0.6087925434112549,
0.43553102016448975,
0.24008643627166748,
-0.2954530417919159,
0.2093454748392105,
0.48453646898269653,
-0.038112346082925797,
0.03144533187150955,
0.3984372615814209,
-0.40846988558769226,
0.005234886426478624,
0.12150468677282333,
-0.54803866147995,
0.6364060044288635,
0.17824433743953705,
0.03200923278927803,
0.11754174530506134,
0.3760172128677368,
-0.1709337681531906,
-0.4210236966609955,
0.3229387700557709,
-0.01305651105940342,
0.04762006923556328,
-0.036464449018239975,
0.048444151878356934,
0.8625648617744446,
0.44807231426239014,
-0.2966158390045166,
0.3855292797088623,
0.008386014960706234,
0.11022832989692688,
-0.4524475038051605,
-0.15429233014583588,
-0.38115429878234863,
0.5717142224311829,
0.3374834954738617,
-0.168036550283432,
-0.5894691348075867,
0.05081412196159363,
-0.24009069800376892,
0.8167667388916016,
0.16773828864097595,
0.23377414047718048,
-0.6643092632293701,
0.5255590677261353,
0.36373433470726013,
0.22932273149490356,
-0.14252814650535583,
0.225779190659523,
-0.3602806627750397,
-0.32172131538391113,
0.5350646376609802,
-0.26946887373924255,
-0.2828090786933899,
0.3332429826259613,
0.23103930056095123,
0.672747015953064,
0.0012538866139948368,
0.03322753682732582,
-0.5494562387466431,
0.09801512956619263,
0.7731299996376038,
-0.3781328797340393,
0.11485561728477478,
0.017343105748295784,
-0.3515143096446991,
0.07511609047651291,
-0.5117570161819458,
0.310813844203949,
0.032886944711208344,
-0.9347100853919983,
0.2933584153652191,
-0.02229328081011772,
-0.08153844624757767,
-0.08145353943109512,
-0.5389201045036316,
0.16534274816513062,
-0.4509260952472687,
-0.5271677374839783,
0.16098105907440186,
0.23931217193603516,
-0.413038045167923,
0.26074355840682983,
0.09384922683238983,
0.11746209114789963,
-0.08471366763114929,
-0.44974157214164734,
-0.05063922330737114,
0.31469282507896423,
-0.15673214197158813,
-0.2797870934009552,
-0.10769126564264297,
0.5217620730400085,
0.06942050904035568,
-0.007325238082557917,
0.07867012172937393,
0.5365033745765686,
-0.17957060039043427,
0.6968254446983337,
-0.765777051448822,
0.7843652963638306,
-0.7188684344291687,
0.1630115956068039,
-0.32861587405204773,
0.13133478164672852,
0.5387179851531982,
0.42567718029022217,
-0.289833664894104,
-0.22454145550727844,
-0.42800021171569824,
-0.11208433657884598,
0.4020240604877472,
-0.0722132995724678,
0.4633724093437195,
-0.24503253400325775,
-0.057290226221084595,
-0.27703434228897095,
0.32714369893074036,
-0.189944788813591,
-0.18871600925922394,
0.07026553899049759,
0.4650213122367859,
0.04071909934282303,
-0.5527086853981018,
0.32581445574760437,
0.027029728516936302,
-0.058221492916345596,
-0.6062676906585693,
0.6167906522750854,
-0.41871312260627747,
-0.021904069930315018,
-0.10366106033325195,
-0.21376436948776245,
0.10609392821788788,
-0.18316936492919922,
-0.1411234736442566,
0.22084730863571167,
0.4205457866191864,
0.15509061515331268,
0.03491588309407234,
0.12821024656295776,
0.06357093155384064,
-0.3437754809856415,
-0.3762781023979187,
0.4586960971355438,
-0.06413274258375168,
0.09139073640108109,
-0.3701596260070801,
0.02894134819507599,
-0.6847832202911377,
-0.04078285023570061,
0.09411276131868362,
-0.2858175039291382,
-0.07163813710212708,
0.1414133906364441
] |
INTRODUCTION: Macrophage activating syndrome is a severe, potentially life-threatening condition that may accompany Still's disease. It is characterized by fever, hepatosplenomegaly, lymphadenopathy, severe cytopenia, serious liver dysfunction, coagulopathy and neurologic involvement. The principal treatment for patients with this syndrome includes etoposide 150 mg/2 M twice a week for two weeks, dexamethasone 10 mg/2 M for two weeks and cyclosporine 3 mg/kg to 5 mg/kg for a longer period. Cases of relapse of macrophage activating syndrome are relatively rare. CASE PRESENTATION: We describe the case of a 15-year-old Iraqi girl with Still's disease who developed macrophage activating syndrome with acute respiratory distress syndrome that required resuscitation and mechanical ventilation. Following intensive treatment, including high dose steroids and cyclosporine, the patient improved significantly. Two weeks after cyclosporine was discontinued, however, she was readmitted with an acute relapse of macrophage activating syndrome manifested by spiking fever, arthralgias, maculopapular rash and leukocytosis. This time the patient recovered following the reintroduction of treatment with cyclosporine and the addition of mycophenolate mofetil (Cellcept). CONCLUSION: We believe that cyclosporine is a cornerstone for the treatment of Still's disease. We recommend continuing this medication for several weeks following the patient's clinical recovery in order to prevent macrophage activating syndrome relapses. | [
0.008154773153364658,
-0.00028154056053608656,
-0.00423428975045681,
0.0021538841538131237,
0.011094332672655582,
0.0009718566434457898,
0.005780414212495089,
-0.0047340234741568565,
-0.007658779621124268,
-0.021785695105791092,
-0.0075201187282800674,
0.008222038857638836,
-0.0024851285852491856,
0.017626164481043816,
-0.00918465107679367,
0.017295492812991142,
-0.024620696902275085,
0.037981048226356506,
0.010693635791540146,
-0.0023894845508038998,
0.005804918706417084,
-0.02151290327310562,
0.008117364719510078,
-0.004270552657544613,
-0.0007630528416484594,
0.012163120321929455,
-0.006229674909263849,
0.016625981777906418,
0.02020946517586708,
0.015691548585891724,
-0.011081553064286709,
0.009489640593528748,
-0.021147470921278,
-0.0010310879442840815,
0.018007010221481323,
-0.00453528668731451,
0.0013758784625679255,
0.005172659642994404,
0.0027910792268812656,
-0.005092902109026909,
-0.009641630575060844,
-0.012487927451729774,
0.0037151603028178215,
-0.023183133453130722,
-0.007686994969844818,
0.000956446398049593,
-0.00109917635563761,
-0.002520381473004818,
-0.007485733833163977,
0.004673505201935768,
-0.009936940856277943,
-0.013384431600570679,
-0.007436169311404228,
-0.00797249749302864,
-0.004271978512406349,
-0.009142648428678513,
0.014869507402181625,
-0.0013101319782435894,
-0.011133285239338875,
0.016238920390605927,
0.020374786108732224,
-0.012402808293700218,
-0.010067320428788662,
0.017253734171390533,
-0.011045007966458797,
-0.06735289841890335,
0.005887520499527454,
0.01312977820634842,
-0.010217530652880669,
-0.0018725799163803458,
-0.008472109213471413,
0.00491792568936944,
-0.00042930874042212963,
0.003539468627423048,
-0.01234411634504795,
-0.02073846571147442,
-0.007953515276312828,
0.008095428347587585,
0.017710860818624496,
-0.009636474773287773,
0.021707722917199135,
-0.014479747973382473,
-0.030409453436732292,
0.0027274745516479015,
-0.008740147575736046,
0.004874114878475666,
-0.01781877502799034,
-0.014224647544324398,
-0.00443627405911684,
-0.0045756069011986256,
0.0012357529485598207,
0.010746491141617298,
-0.003424776252359152,
0.006887437310069799,
-0.02580951154232025,
-0.006778352428227663,
-0.010895851999521255,
-0.01721877232193947,
-0.022198345512151718,
-0.010270345956087112,
-0.01938468962907791,
-0.003817282384261489,
0.006887373048812151,
-0.002333663171157241,
-0.018700912594795227,
0.0017676199786365032,
-0.007467019371688366,
0.013458460569381714,
0.02168450877070427,
0.011395842768251896,
-0.026468446478247643,
0.009136281907558441,
-0.01658146269619465,
0.0007793828845024109,
0.014301636256277561,
0.0021417541429400444,
0.004503543488681316,
0.023737914860248566,
0.0133714210242033,
0.011134935542941093,
0.007436974905431271,
0.008612473495304585,
0.008633439429104328,
-0.007394608575850725,
0.0003102573100477457,
0.010955891571938992,
0.0038928287103772163,
0.002928146393969655,
-0.001108475960791111,
-0.004060130566358566,
-0.004921242594718933,
0.007157330401241779,
0.005041349679231644,
0.0032630686182528734,
0.002406338695436716,
-0.0015110747190192342,
-0.005541735328733921,
-0.008041661232709885,
-0.005637649446725845,
0.0018562176264822483,
-0.003979458939284086,
0.005579479970037937,
0.003376663662493229,
0.00450900150462985,
0.006442861631512642,
0.002088995650410652,
0.004110709298402071,
0.004734997637569904,
0.015767309814691544,
0.020714640617370605,
0.00943729467689991,
-0.008228380233049393,
-0.017588375136256218,
-0.00936866831034422,
0.0032978281378746033,
-0.008370067924261093,
-0.010988060384988785,
-0.006493967026472092,
0.007015330716967583,
0.013977836817502975,
0.003763173706829548,
-0.005149092525243759,
0.014034466817975044,
0.008013514801859856,
0.016665806993842125,
-0.014341088011860847,
-0.024345841258764267,
-0.008368071168661118,
0.00880541279911995,
0.004167826846241951,
-0.0024630639236420393,
0.004416312091052532,
-0.02361101657152176,
0.0033101607114076614,
-0.01682918518781662,
0.004494497552514076,
-0.008249841630458832,
0.0048155649565160275,
-0.01037221122533083,
0.06615212559700012,
0.0007147116120904684,
0.0016380609013140202,
0.00020799343474209309,
-0.008907724171876907,
0.017813241109251976,
0.0034022931940853596,
0.004217796493321657,
-0.0013808608055114746,
-0.016333943232893944,
-0.0015246091643348336,
0.028375307098031044,
0.009803315624594688,
-0.010374709963798523,
-0.00036829058080911636,
-0.03557482361793518,
0.0031319998670369387,
-0.0015348269371315837,
0.013654699549078941,
0.012476759031414986,
-0.0067044831812381744,
0.03034737892448902,
-0.013883558101952076,
0.01625918224453926,
-0.010330927558243275,
0.006725984625518322,
0.005321572534739971,
0.0022506164386868477,
-0.0012525510974228382,
-0.007641442585736513,
0.0046267942525446415,
-0.0013246815651655197,
0.010985271073877811,
0.006956943776458502,
-0.002728366758674383,
-0.01593567058444023,
0.005848386324942112,
-0.003534630173817277,
0.00967828743159771,
0.0016959651838988066,
-0.0059929294511675835,
0.0009486518683843315,
-0.005571561865508556,
0.002640752587467432,
0.0053365807980299,
0.010050047188997269,
0.00020560587290674448,
0.007973813451826572,
0.009147705510258675,
-0.003335168119519949,
0.004357700701802969,
-0.026786819100379944,
0.0022827829234302044,
-0.010384360328316689,
-0.0013598105870187283,
-0.0028329493943601847,
0.002193211577832699,
0.00967932865023613,
0.007364625111222267,
0.02310802787542343,
-0.01957423985004425,
-0.007275456562638283,
0.0025867819786071777,
-0.00767632108181715,
0.01603139564394951,
-0.016074586659669876,
-0.009964806959033012,
0.017219293862581253,
0.004167228937149048,
0.01158935111016035,
-0.002792936284095049,
0.005849585868418217,
-0.009310967288911343,
-0.012399952858686447,
0.009923850186169147,
0.018271401524543762,
-0.01012394204735756,
-0.036037884652614594,
-0.009375689551234245,
0.023052476346492767,
0.018732519820332527,
0.008690735325217247,
0.006217504385858774,
-0.0001557525247335434,
0.004774138331413269,
0.00011699204333126545,
0.0077333818189799786,
0.006075568962842226,
-0.019855134189128876,
0.013520877808332443,
0.012902811169624329,
0.005608630366623402,
0.0022329429630190134,
-0.009852854534983635,
-0.08178465813398361,
-0.008906085044145584,
-0.008272132836282253,
-0.007698228117078543,
0.0060746134258806705,
-0.009841544553637505,
0.008923392742872238,
-0.003970507066696882,
-0.010895720683038235,
-0.0019600673113018274,
-0.007295969873666763,
0.010596347972750664,
-0.0012338904198259115,
-0.008553562685847282,
-0.00870558712631464,
0.004350274335592985,
0.010958811268210411,
0.011872215196490288,
0.010867821052670479,
-0.02126420848071575,
0.01771663874387741,
0.006847401615232229,
0.016162985935807228,
-0.009737329557538033,
-0.012437239289283752,
0.019938655197620392,
0.0030923839658498764,
-0.0033266176469624043,
-0.013730103150010109,
0.009168820455670357,
-0.000254159327596426,
0.0017418942879885435,
0.017246700823307037,
-0.000897405669093132,
-0.016098489984869957,
0.006807585246860981,
0.010182749480009079,
-0.008465131744742393,
-0.012386241927742958,
0.015704497694969177,
-0.011447779834270477,
0.00014529190957546234,
0.013770625926554203,
-0.001784318359568715,
-0.003110730554908514,
0.010612159967422485,
0.004562749527394772,
-0.026860103011131287,
0.01635366678237915,
-0.013362804427742958,
0.004000967834144831,
0.0025640325620770454,
0.006734281778335571,
0.017899401485919952,
-0.016087472438812256,
-0.010676403529942036,
-0.013921612873673439,
0.011606727726757526,
-0.0041172257624566555,
-0.013543948531150818,
0.01059388741850853,
-0.017892923206090927,
0.02682311087846756,
0.011041977442800999,
-0.016949865967035294,
0.00306537002325058,
0.014871608465909958,
-0.0019627995789051056,
-0.013529151678085327,
-0.005661027505993843,
-0.009467649273574352,
0.004696157295256853,
-0.010620174929499626,
-0.005625246558338404,
0.0004454192239791155,
-0.007350436411798,
-0.011262346059083939,
-0.00326851150020957,
0.0006151767447590828,
-0.015691034495830536,
-0.03469045087695122,
-0.0026674852706491947,
-0.010129926726222038,
0.022189388051629066,
-0.012227294035255909,
-0.00959708634763956,
0.005136784166097641,
-0.002057960256934166,
0.0042776139453053474,
-0.011273836717009544,
-0.020223915576934814,
0.0099418256431818,
-0.00886807031929493,
0.010286981239914894,
0.019418664276599884,
-0.002113903407007456,
0.016378669068217278,
-0.027137847617268562,
0.01930619776248932,
0.005728346761316061,
-0.016606681048870087,
0.0001869050320237875,
0.005464933346956968,
-0.008099508471786976,
-0.004161871038377285,
0.014912540093064308,
0.00220669386908412,
0.007173230871558189,
0.0060474928468465805,
0.003931115381419659,
0.005932467989623547,
0.012008730322122574,
-0.006487153470516205,
-0.0018766575958579779,
0.007115848828107119,
0.00974244624376297,
0.010895704850554466,
-0.020620889961719513,
0.073483407497406,
-0.0060441805981099606,
-0.004204352851957083,
-0.010475866496562958,
0.011216046288609505,
-0.00985113438218832,
0.0012652697041630745,
0.012618731707334518,
0.01794620417058468,
0.015375339426100254,
0.010127803310751915,
0.01888330839574337,
-0.02112274244427681,
-0.0021229046396911144,
-0.024760719388723373,
0.007579579018056393,
-0.01114579662680626,
-0.028408421203494072,
0.03175145015120506,
0.012996305711567402,
0.012953631579875946,
-0.018094025552272797,
-0.009834161028265953,
0.005406999494880438,
-0.007686035241931677,
-0.0005627172067761421,
-0.018134744837880135,
-0.008656619116663933,
-0.010715910233557224,
0.007845078594982624,
0.005308900959789753,
0.00820339098572731,
-0.008562056347727776,
-0.009709618054330349,
0.01744227483868599,
-0.010811720974743366,
-0.0024800661485642195,
-0.01085656974464655,
0.015081528574228287,
-0.005385391414165497,
0.009200703352689743,
-0.01695195958018303,
-0.008624366484582424,
-0.00007125129923224449,
-0.01496890839189291,
-0.008729223161935806,
0.008287077769637108,
-0.007559287361800671,
-0.0006627377588301897,
-0.002717034425586462,
-0.0015034365933388472,
0.004129876848310232,
0.012781494297087193,
0.00541728874668479,
0.010478594340384007,
-0.0017657699063420296,
0.015018719248473644,
-0.010482870042324066,
-0.014406496658921242,
-0.007402586750686169,
0.0023441927041858435,
0.015836777165532112,
-0.015396016649901867,
0.002283882349729538,
0.0053320652805268764,
-0.007836402393877506,
0.015915771946310997,
0.013198898173868656,
-0.005851982161402702,
0.0011858991347253323,
0.0022831344977021217,
0.014791412279009819,
-0.02599930949509144,
-0.009160639718174934,
-0.028230832889676094,
-0.005239925347268581,
0.009694045409560204,
-0.0013216598890721798,
0.017759501934051514,
-0.014941238798201084,
-0.013142116367816925,
0.01959828846156597,
-0.008226878009736538,
0.01718585193157196,
0.01322170440107584,
-0.018096525222063065,
-0.020136568695306778,
-0.07550851255655289,
0.003637026995420456,
-0.020927026867866516,
-0.004848637618124485,
0.00023242738097906113,
-0.0002720665652304888,
-0.013966677710413933,
0.0061517334543168545,
0.022793931886553764,
-0.009095869027078152,
0.004230984952300787,
0.019084084779024124,
0.0005068653263151646,
-0.004145478829741478,
0.008302293717861176,
-0.00033927662298083305,
0.01335906982421875,
0.004470860585570335,
-0.03571701794862747,
0.008388013578951359,
0.0007259926642291248,
0.0025104149244725704,
-0.009285381063818932,
-0.0024685654789209366,
-0.016408191993832588,
-0.082557812333107,
-0.007868521846830845,
-0.00552759226411581,
0.012276830151677132,
-0.017972860485315323,
-0.007028230000287294,
0.011111410334706306,
-0.011568063870072365,
0.00826273299753666,
-0.010533863678574562,
0.010146506130695343,
-0.009240463376045227,
0.004870457574725151,
-0.0015678470954298973,
-0.0014779421035200357,
-0.004067661240696907,
0.009217384271323681,
0.02560241147875786,
-0.004324362147599459,
-0.0029080500826239586,
-0.008471226319670677,
0.00017399038188159466,
-0.0035927104763686657,
-0.0005582089070230722,
-0.006165599916130304,
-0.005632052198052406,
-0.0011569398920983076,
0.013492017984390259,
0.01066987682133913,
-0.013124458491802216,
-0.016745012253522873,
-0.0038587478920817375,
-0.0066900975070893764,
0.003758938517421484,
-0.015817366540431976,
-0.00005837343633174896,
-0.0009054755792021751,
-0.003918691072613001,
-0.0046408697962760925,
-0.02194199711084366,
-0.000858795887324959,
-0.010668539442121983,
-0.01507449522614479,
-0.01888151839375496,
-0.004470041021704674,
0.008023342117667198,
0.003254640381783247,
-0.008297860622406006,
0.00428788922727108,
-0.010147025808691978,
0.008184303529560566,
-0.004475695081055164,
0.010144048370420933,
-0.010573320090770721,
-0.0012409379705786705,
0.010553327389061451,
-0.015579198487102985,
0.006087483838200569,
0.032474879175424576,
-0.0006667922134511173,
-0.006325113121420145,
0.009674771688878536,
0.02493520826101303,
0.07134633511304855,
0.007502848748117685,
0.0015918943099677563,
-0.0093632647767663,
0.013871945440769196,
0.008421961218118668,
0.00933913979679346,
-0.003010884393006563,
-0.010396995581686497,
0.013469027355313301,
0.0007596956565976143,
-0.011114081367850304,
0.012086369097232819,
0.011279378086328506,
0.00005241134203970432,
0.00011099223047494888,
-0.007790827192366123,
0.0010002774652093649,
0.00860515981912613,
0.019049210473895073,
0.0059537021443247795,
-0.007797163911163807,
-0.030346158891916275,
0.014691641554236412,
0.0016512067522853613,
-0.002269270597025752,
-0.0025610513985157013,
0.00886922050267458,
-0.009975079447031021,
-0.002291151788085699,
-0.008341706357896328,
-0.010879332199692726,
-0.00026742770569399,
0.003061865922063589,
0.010244910605251789,
-0.0031963028013706207,
-0.005158707499504089,
0.00909108854830265,
-0.011629298329353333,
0.007427841424942017,
-0.0017272753175348043,
-0.012401473708450794,
-0.002133950125426054,
0.009413338266313076,
0.02634645625948906,
-0.0041121975518763065,
-0.013659133575856686,
0.0012283911928534508,
0.00399799644947052,
0.00035102805122733116,
0.0009760702960193157,
0.006342936307191849,
-0.007421121932566166,
-0.0064621493220329285,
0.010855525732040405,
0.03249605745077133,
-0.00974206067621708,
0.00385994091629982,
-0.009074489586055279,
-0.019781485199928284,
0.01494552195072174,
-0.007685208693146706,
-0.007545131724327803,
-0.014388760551810265,
0.012892375700175762,
0.0055164857767522335,
0.01761745847761631,
-0.012563569471240044,
-0.016906578093767166,
0.011529892683029175,
-0.00009813020005822182,
-0.0006709593581035733,
0.008324017748236656,
-0.01163431815803051,
0.007366141304373741,
0.013382120989263058,
-0.014890092425048351,
-0.009644689038395882,
0.000514460145495832,
0.010604043491184711,
-0.006756215821951628,
0.001025870442390442,
-0.009163053706288338,
0.021000554785132408,
0.00994061678647995,
-0.005346411373466253,
-0.001835899194702506,
0.004981944337487221,
0.0001575734931975603,
0.0042873891070485115,
0.012750147841870785,
0.011955498717725277,
0.006052335724234581,
0.009231967851519585,
0.00852966494858265,
0.032906778156757355,
0.0015569579554721713,
0.002162687946110964,
-0.012242494150996208,
0.008970733731985092,
-0.003307844279333949,
-0.016957174986600876,
0.00643570814281702,
-0.0018844215665012598,
-0.014976557344198227,
-0.000864255940541625,
0.006699449382722378,
0.018108993768692017,
-0.013839054852724075,
0.0022549929562956095,
0.013058420270681381,
-0.016508091241121292,
-0.00014591077342629433,
-0.004664369858801365,
0.006650413386523724,
0.011934801936149597,
-0.0030650473199784756,
-0.014840861782431602,
-0.0005374508909881115,
-0.01405036635696888,
0.0007513479795306921,
-0.010980602353811264,
-0.007275933865457773,
-0.008773568086326122,
-0.0023140409030020237,
-0.021969188004732132,
-0.004997756332159042,
-0.00679611973464489,
0.008971387520432472,
0.0018469356000423431,
0.007284310180693865,
-0.015682943165302277,
-0.02201945334672928,
0.01169466320425272,
-0.004010205622762442,
-0.022930435836315155,
0.0120211411267519,
0.00854430440813303,
0.006600405555218458,
-0.02924465760588646,
0.039863329380750656,
-0.008566075935959816,
0.004564189352095127,
-0.010077045299112797,
0.008135765790939331,
-0.0050153122283518314,
-0.004050506744533777,
0.0006622193614020944,
0.010244857519865036,
-0.007805546745657921,
0.0030718024354428053,
-0.00039056933019310236,
-0.006304953247308731,
-0.006708127912133932,
0.014292759820818901,
0.025006208568811417,
0.0011208831565454602,
0.004903790540993214,
-0.01614616997539997,
-0.014196544885635376,
-0.00451416801661253,
-0.0031263912096619606,
-0.007392406929284334,
0.001491182018071413,
0.006406079512089491,
0.01816186122596264,
-0.005425515118986368,
0.028279047459363937,
0.010865987278521061,
0.00627673976123333,
0.017283037304878235,
0.01635275036096573,
0.0057468051090836525,
-0.017094671726226807,
-0.024694710969924927,
0.005379052832722664,
0.006285031326115131,
-0.008094925433397293,
0.011352910660207272,
0.010486608371138573,
0.0087982676923275,
-0.012187279760837555,
-0.00325268367305398,
-0.006401400081813335,
-0.008417079225182533,
-0.002080751582980156,
-0.020571958273649216,
0.005979421082884073,
-0.0024566096253693104,
0.00994114764034748,
-0.011142518371343613,
0.01059806440025568,
0.007529490161687136,
0.001995410304516554,
0.013814227655529976,
0.006337519735097885,
0.01798184961080551,
-0.0016085212118923664,
0.007578058168292046,
-0.0050355177372694016,
0.004736071452498436,
-0.018208403140306473
] | [
0.16347385942935944,
0.11004062741994858,
0.41675060987472534,
-0.2096153348684311,
0.2937583327293396,
0.012596063315868378,
0.0639076977968216,
0.3088180720806122,
-0.2109457552433014,
-0.3080389201641083,
-0.2178478240966797,
0.19039230048656464,
-0.5826991200447083,
0.07765176147222519,
0.08029285073280334,
0.9089893102645874,
0.7552287578582764,
0.2135924994945526,
-0.25240880250930786,
-0.22445520758628845,
0.052929721772670746,
-0.3173244595527649,
0.5558186769485474,
-0.41470903158187866,
0.23554104566574097,
-0.20112785696983337,
0.1778341829776764,
0.2164713591337204,
0.11938605457544327,
-0.3012266755104065,
-0.16110841929912567,
0.32667165994644165,
0.5520200133323669,
-0.21435372531414032,
0.0801919624209404,
0.7478954792022705,
-0.11073391139507294,
-0.15744152665138245,
-0.1351945996284485,
-0.3998089134693146,
-0.29009345173835754,
-0.03481719270348549,
0.04261428490281105,
0.24103333055973053,
0.016108885407447815,
-0.1093783751130104,
-0.9918617010116577,
0.29416143894195557,
-0.2772715985774994,
-0.354292631149292,
0.09022240340709686,
0.3786322772502899,
0.7758749723434448,
-0.584534227848053,
0.2774411141872406,
-0.28866952657699585,
-1.1716208457946777,
-0.32512781023979187,
-0.09358174353837967,
-0.16077187657356262,
0.16552750766277313,
-0.3594152629375458,
-0.18667708337306976,
0.43318286538124084,
-0.3440253734588623,
0.22132855653762817,
-0.45532625913619995,
0.4313850700855255,
-0.09289146214723587,
0.12615744769573212,
0.39723020792007446,
-0.0826902762055397,
-0.25208190083503723,
0.1943894326686859,
0.232037752866745,
-0.025416618213057518,
-0.22982631623744965,
-0.46042799949645996,
0.27116963267326355,
0.22383809089660645,
0.11911667138338089,
-0.12925057113170624,
0.6524103283882141,
0.04512975364923477,
0.30387383699417114,
0.16933254897594452,
-0.18171724677085876,
1.1044776439666748,
-0.5825182199478149,
0.16862575709819794,
0.1530974954366684,
-0.17521719634532928,
0.6063678860664368,
-0.4017353653907776,
-0.25760266184806824,
-0.01774129457771778,
-0.255132257938385,
0.12589740753173828,
-0.0869574099779129,
0.2911147177219391,
-0.05053846538066864,
-0.07221405953168869,
-0.25641635060310364,
-0.12915806472301483,
0.03962970897555351,
0.012924126349389553,
-0.2904209494590759,
-0.5232024788856506,
-0.45970895886421204,
0.027964748442173004,
-0.8320890069007874,
-0.1371413916349411,
0.024816352874040604,
-0.25436800718307495,
-0.2686590254306793,
0.39389124512672424,
0.015378709882497787,
0.06046851724386215,
-0.3620336353778839,
-0.0036726659163832664,
-0.14701710641384125,
0.2003515064716339,
-0.155974879860878,
0.03896268084645271,
0.06045345216989517,
0.08026832342147827,
-0.00694079278036952,
-0.048022184520959854,
0.03164106234908104,
0.6204510927200317,
-0.01753903739154339,
0.23191839456558228,
-0.41331979632377625,
-0.3042450249195099,
0.21386370062828064,
-0.278413325548172,
-0.34530434012413025,
-0.07244209945201874,
0.40051740407943726,
0.462279349565506,
-0.20681190490722656,
0.14907190203666687,
-0.5914556980133057,
0.5137055516242981,
0.08350009471178055,
-0.1814904361963272,
-0.4582809805870056,
0.40491434931755066,
-0.2708791494369507,
0.07461464405059814,
0.13655275106430054,
-0.18868565559387207,
-0.5211451053619385,
0.22147811949253082,
-0.20663844048976898,
0.19791048765182495,
-0.2509773075580597,
-0.5765022039413452,
-0.20528173446655273,
0.14011752605438232,
0.6219711303710938,
0.12878824770450592,
-0.37861496210098267,
-0.4215749204158783,
0.7855374813079834,
-0.1654432713985443,
-0.2843840420246124,
-0.0013068116968497634,
0.22736801207065582,
0.14851345121860504,
-0.05041533708572388,
0.19178830087184906,
0.07580598443746567,
-0.7578761577606201,
0.3492354452610016,
0.5336886644363403,
0.24088995158672333,
0.3829907476902008,
0.3960191011428833,
-0.1608966588973999,
-0.6059414744377136,
0.01942823827266693,
-0.01150676142424345,
-0.4992687702178955,
0.005799830425530672,
-0.11786235868930817,
0.45342254638671875,
0.004740410018712282,
0.45262375473976135,
-0.03877406194806099,
-0.3577382564544678,
0.15996411442756653,
0.767434298992157,
-0.25460535287857056,
1.0211961269378662,
-0.42146995663642883,
-0.15216389298439026,
0.5312907099723816,
0.004343491513282061,
-0.28119879961013794,
0.08036357164382935,
0.48760348558425903,
0.4110909700393677,
-0.1406460553407669,
-0.5123968124389648,
0.2378249317407608,
-0.055989768356084824,
-0.5443701148033142,
0.1451261341571808,
0.5358705520629883,
0.3809010684490204,
-0.4957706928253174,
0.16170530021190643,
-0.007527060806751251,
0.5484910011291504,
-0.2382216602563858,
0.367435097694397,
0.06597201526165009,
0.0283583365380764,
-0.19896896183490753,
-0.0012137112207710743,
-0.4116959869861603,
-0.1956501454114914,
0.5672875046730042,
-0.32777056097984314,
0.10464721918106079,
0.3397837281227112,
-0.41170769929885864,
0.5042597055435181,
-0.41996434330940247,
0.07584630697965622,
-0.10307199507951736,
0.1964622139930725,
-0.35261857509613037,
-0.013497494161128998,
0.2471383810043335,
-0.3276037275791168,
-0.17297446727752686,
-0.28046926856040955,
-0.5871579051017761,
0.382559210062027,
0.32430189847946167,
-0.46488600969314575,
0.017019908875226974,
0.22180303931236267,
-0.17495739459991455,
0.0984993577003479,
0.5994874835014343,
-0.9288599491119385,
-0.4604262709617615,
0.23087474703788757,
0.616978108882904,
0.35511690378189087,
-0.5660053491592407,
-0.03815355896949768,
-0.07461534440517426,
-0.18793363869190216,
-0.2185831367969513,
0.1520606279373169,
0.2303900569677353,
-0.47814077138900757,
0.4531501829624176,
0.36877161264419556,
0.424028605222702,
-0.20133298635482788,
-0.39326080679893494,
-0.735314130783081,
-0.694359302520752,
0.24090076982975006,
0.16169758141040802,
0.6284720301628113,
0.045317143201828,
-0.9286804795265198,
0.04543494060635567,
-0.43255409598350525,
-0.37365585565567017,
0.2320464849472046,
0.8773849606513977,
-0.8271495699882507,
-0.22319236397743225,
0.026959389448165894,
0.921552300453186,
0.695178210735321,
0.074653759598732,
-0.48759815096855164,
-0.6227185726165771,
-0.36582106351852417,
-0.4848703444004059,
-0.28909415006637573,
-0.6547644138336182,
-0.38760530948638916,
0.6094556450843811,
-0.057327449321746826,
-0.17429521679878235,
-0.12288343161344528,
0.043570976704359055,
-0.23612098395824432,
0.54694664478302,
0.5775773525238037,
-0.026835624128580093,
0.08008292317390442,
0.25521427392959595,
0.35994359850883484,
0.05160744488239288,
0.02900156006217003,
-0.1626402735710144,
-0.3499123454093933,
0.08004477620124817,
-6.06582498550415,
-0.07922010123729706,
-0.1817949116230011,
-0.36477044224739075,
0.19078123569488525,
0.02654316835105419,
0.9942275881767273,
-0.007686831057071686,
0.3076797127723694,
0.4531860947608948,
-0.17514538764953613,
0.5394957661628723,
0.17384421825408936,
-0.08008813858032227,
-0.03785819932818413,
-0.16464506089687347,
-0.237309530377388,
-0.33983027935028076,
0.6198702454566956,
0.2128363400697708,
0.32738620042800903,
-0.24770036339759827,
0.2662525773048401,
0.8439376950263977,
0.16256901621818542,
0.4416044056415558,
-0.9183266162872314,
0.751710057258606,
-0.2887409031391144,
0.268460750579834,
0.18650636076927185,
-0.8282496929168701,
0.16726739704608917,
-0.0274835042655468,
-0.15098854899406433,
0.0326802097260952,
-0.2349623143672943,
-0.18658699095249176,
-0.4021154046058655,
-0.5728281736373901,
0.041795048862695694,
0.15152502059936523,
-0.2959898114204407,
0.19049201905727386,
0.2145635038614273,
0.12761448323726654,
0.26058268547058105,
0.027858149260282516,
0.10826940834522247,
1.0518211126327515,
0.1762247085571289,
-0.20492658019065857,
-0.12999890744686127,
0.1633700728416443,
0.05643162131309509,
0.2198553830385208,
-0.15035341680049896,
0.1390981376171112,
0.060044243931770325,
0.1857064664363861,
0.01159222237765789,
0.026380404829978943,
-0.17270000278949738,
-0.09629840403795242,
-0.0943538025021553,
0.0534256286919117,
-0.37391340732574463,
0.4337352514266968,
0.7323260307312012,
-0.013940089382231236,
-0.15758344531059265,
0.4537010192871094,
0.42910027503967285,
-0.8920974731445312,
0.23708213865756989,
-0.22733424603939056,
0.0018198274774476886,
0.21944624185562134,
0.02700677700340748,
0.05510019138455391,
-0.1691592037677765,
0.1607062667608261,
0.43619975447654724,
0.3444300889968872,
0.30482301115989685,
-0.5100010633468628,
0.18661974370479584,
-0.03269471600651741,
0.07959137111902237,
0.02859247475862503,
0.4127142131328583,
-0.24694813787937164,
0.07763129472732544,
0.2047705054283142,
0.2842366397380829,
0.5739587545394897,
0.28859755396842957,
0.43794527649879456,
0.2738956809043884,
0.06990031898021698,
0.7495551109313965,
-0.12138167023658752,
-0.06033407524228096,
-0.9771179556846619,
0.023326564580202103,
-0.25165411829948425,
-0.5123404264450073,
0.24434137344360352,
0.3360014855861664,
-0.2708372175693512,
-0.040453020483255386,
0.18611520528793335,
-0.423883855342865,
-0.46028634905815125,
0.36883971095085144,
0.13803894817829132,
0.15015970170497894,
0.04568552225828171,
0.21054217219352722,
-0.3247988820075989,
-0.4150489568710327,
0.23423242568969727,
-0.36532625555992126,
0.25051894783973694,
-0.3256390690803528,
0.2586534023284912,
0.34706395864486694,
0.3765668272972107,
-0.3261883556842804,
0.1381080150604248,
-0.15245841443538666,
0.552716851234436,
-0.222469300031662,
-0.2645500600337982,
0.5278468728065491,
-0.3799733519554138,
-0.5039501786231995,
0.2427474707365036,
0.26906442642211914,
-0.16013504564762115,
-0.2146865576505661,
-0.169562429189682,
-0.2725210189819336,
0.06243036314845085,
-0.25925830006599426,
-0.09565829485654831,
0.06364911794662476,
0.07148061692714691,
-0.06115216016769409,
0.39980384707450867,
0.5846235752105713,
0.30057477951049805,
-0.11272422224283218,
0.4189853370189667,
-0.5792001485824585,
-0.21600252389907837,
0.5375731587409973,
0.09801703691482544,
0.323132187128067,
-0.5191194415092468,
0.007712533697485924,
-0.2411346435546875,
-1.187309741973877,
-0.12908753752708435,
0.22214296460151672,
-0.549482524394989,
0.018668554723262787,
-0.49538129568099976,
-0.11211813241243362,
0.16869789361953735,
-0.5573500394821167,
-0.4971085786819458,
-0.0542009174823761,
0.4491918683052063,
0.5739735960960388,
-0.06023812294006348,
-0.5915137529373169,
-0.2646695077419281,
-0.08172239363193512,
0.16594572365283966,
0.18796776235103607,
-0.5581700801849365,
-0.39471668004989624,
0.2643154263496399,
0.6748292446136475,
-0.0366114042699337,
-0.054729435592889786,
-0.518096923828125,
-0.11513200402259827,
-0.4039846360683441,
0.4684044122695923,
0.2271435409784317,
0.4545729160308838,
0.48397156596183777,
0.09746284037828445,
-0.06340077519416809,
-0.25774428248405457,
0.9621501564979553,
0.18909987807273865,
-0.0493408627808094,
-0.14418236911296844,
0.052863601595163345,
-0.002871719654649496,
0.2911214232444763,
0.7805178165435791,
0.1165120080113411,
0.0015545465284958482,
-0.12027250975370407,
-0.26901060342788696,
-0.36862698197364807,
-0.04791320487856865,
-0.7432330846786499,
-0.48773983120918274,
0.30670490860939026,
-0.34907400608062744,
0.32419919967651367,
-0.12898008525371552,
-0.7404878735542297,
-0.042604658752679825,
0.28634199500083923,
0.14028476178646088,
-0.07584364712238312,
0.09530103951692581,
-0.08681531250476837,
-0.2859000265598297,
0.40938907861709595,
0.9836138486862183,
-0.7137553691864014,
0.03397368639707565,
0.027880722656846046,
0.27843785285949707,
-0.23488035798072815,
0.2527634799480438,
0.020428713411092758,
-0.5472596287727356,
0.10367316752672195,
-0.23212464153766632,
-0.2965129613876343,
-0.11071763932704926,
0.05713411420583725,
-0.36697855591773987,
0.4099336564540863,
-0.4962293207645416,
-0.3537977337837219,
-0.21774539351463318,
0.22402462363243103,
0.5561384558677673,
-0.5867972373962402,
-0.034533701837062836,
0.38823285698890686,
0.7090580463409424,
0.3415203392505646,
0.2663562595844269,
-0.22892388701438904,
0.28969213366508484,
-0.6049913167953491,
-0.11582378298044205,
-0.41683605313301086,
0.04539621248841286,
0.08993740379810333,
-0.21564169228076935,
0.3491246700286865,
0.16132044792175293,
0.2919268310070038,
-0.06405908614397049,
0.07434271275997162,
-0.012670706957578659,
-0.19286797940731049,
0.4393947720527649,
-0.1963372826576233,
-0.39017948508262634,
-0.18497218191623688,
0.48830294609069824,
0.6933714747428894,
0.11663408577442169,
0.299899160861969,
-0.6183496713638306,
-0.6273481249809265,
-0.6243617534637451,
0.9168757200241089,
-0.13535647094249725,
-0.4076618552207947,
-0.10615772753953934,
-0.3656841516494751,
0.4560733735561371,
-0.8698543906211853,
0.03684120625257492,
-0.1250782310962677,
-0.19685351848602295,
-0.08171256631612778,
0.03133402764797211,
0.43167176842689514,
-0.4387269616127014,
-0.681096076965332,
-0.34666040539741516,
0.282348096370697,
-0.1745416820049286,
-0.07173608988523483,
0.024977972730994225,
-0.2520582675933838,
-0.16974671185016632,
0.1906735748052597,
0.8935010433197021,
-0.31607457995414734,
-0.23925377428531647,
0.265653520822525,
-0.190534308552742,
-0.4416027367115021,
-0.46270260214805603,
0.08546894788742065,
0.42656612396240234,
0.04128178209066391,
0.21400120854377747,
0.5410916209220886,
-0.4398508071899414,
0.11483673751354218,
-0.38243216276168823,
-0.04316924884915352,
-0.007466777693480253,
0.10089260339736938,
0.34155526757240295,
0.44901421666145325,
0.23356015980243683,
-0.16557124257087708,
-0.5668066143989563,
0.41850903630256653,
0.2262933999300003,
0.15135252475738525,
-0.281425416469574,
0.23144525289535522,
0.6207373142242432,
0.5660874247550964,
0.17669473588466644,
0.6161352396011353,
0.12519150972366333,
0.4488937258720398,
0.3228415846824646,
-0.7121641039848328,
-0.19627465307712555,
-0.47205817699432373,
0.8884041905403137,
-0.012200106866657734,
-0.12766651809215546,
-0.2249874323606491,
0.18754935264587402,
0.5545421242713928,
0.004308187402784824,
-0.4257363975048065,
0.32525646686553955,
0.1299772411584854,
0.4185218811035156,
0.11782395094633102,
-0.5649901628494263,
-0.25104543566703796,
-0.184347465634346,
0.14664331078529358,
0.20864135026931763,
-0.4638061225414276,
-0.36144518852233887,
-0.12097012996673584,
-0.10108914971351624,
0.2934517562389374,
-0.2818225622177124,
0.5093608498573303,
0.09598178416490555,
-0.22374223172664642,
0.06489484757184982,
-0.24769960343837738,
0.18904492259025574,
0.338839054107666,
-0.047512494027614594,
-0.2890038788318634,
0.036544475704431534,
-0.07056611776351929,
0.48108527064323425,
-0.1006835401058197,
0.18591946363449097,
0.7145183086395264,
0.3353003263473511,
0.3443199694156647,
-0.5793214440345764,
0.2760794460773468,
-0.5197048783302307,
-0.26570889353752136,
-0.31705403327941895,
0.016607671976089478,
-0.33116233348846436,
-0.24217814207077026,
-0.22990161180496216,
0.07013329863548279,
-0.06361468136310577,
-0.326614648103714,
-0.15433193743228912,
-0.2971043586730957,
0.5572799444198608,
-0.42995232343673706,
0.40069296956062317,
0.540256142616272,
-0.04053850844502449,
0.40682557225227356,
0.035118572413921356,
-0.06287887692451477,
-0.15645858645439148,
0.0431949608027935,
-0.02382786199450493,
0.5082120895385742,
-0.3790600895881653,
0.587936282157898,
-0.7221798300743103,
0.3177799880504608,
0.672778308391571,
1.0314730405807495,
-0.4387276768684387,
0.42139431834220886,
-0.09807997196912766,
-0.2634728252887726,
0.040018390864133835,
-0.4860913157463074,
-0.2744206488132477,
-0.898032546043396,
-0.010765990242362022,
-0.22775515913963318,
0.47700515389442444,
-0.10746107995510101,
-0.6627900004386902,
0.09844430536031723,
0.14667856693267822,
0.25331103801727295,
0.12918464839458466,
0.31326377391815186,
-0.1412753164768219,
-0.007683868054300547,
0.02095911093056202,
0.0262309517711401,
-0.9319645166397095,
0.04004857316613197,
0.40210992097854614,
0.10934310406446457,
-0.3912461996078491,
0.1267608404159546,
0.2895824909210205,
-0.22537900507450104,
-0.22425274550914764,
-0.23523500561714172,
0.1738976389169693,
0.019560394808650017,
-0.016649851575493813,
-0.3311091363430023,
-0.884046196937561,
0.05832045152783394,
-0.04791247472167015,
-0.47792568802833557,
-0.3956718146800995,
-0.024114686995744705,
0.28303050994873047,
-0.06697392463684082,
-0.12302924692630768,
-0.25072920322418213,
-0.4340322017669678,
-0.027663912624120712
] |
Acinetobacter species are well-known causes of nosocomial infections. Recent increasing evidence emphasize on the role of these pathogens in community-acquired infections. We report a case of a 16-yr-old female with fever, sore throat, productive cough, malaise and the presence of lung consolidation with multiple abscesses on radiographic examination. The patient had no significant medical history. After a detailed diagnostic work-up the diagnosis of community acquired Acinetobacter pneumonia with multiple lung abscesses was made. The Acinetobacter stain was susceptible to a variety of antimicrobial agents and the patient's condition improved rapidly. A new computed tomography chest scan, three months later, confirmed full recovery. The presence of lung abscesses due to Acinetobacter infection is an extremely uncommon manifestation of the disease. This case underlines the emergent role which these, often multi-drug resistant, bacteria may play in the future, perhaps in community infections as well. | [
-0.027136605232954025,
0.012773997150361538,
0.0064254687167704105,
0.029262250289320946,
-0.011056549847126007,
-0.01776193268597126,
0.009603789076209068,
0.03664463013410568,
-0.01545773260295391,
0.03556876257061958,
0.0012209375854581594,
0.02074155956506729,
0.010570058599114418,
0.017964383587241173,
-0.019412048161029816,
-0.0054078176617622375,
-0.013244245201349258,
0.017661280930042267,
0.011346422135829926,
-0.03996286168694496,
0.006556137464940548,
-0.024351026862859726,
0.008978428319096565,
0.014931153506040573,
-0.0010211467742919922,
0.02768883854150772,
0.0007556900382041931,
0.009603342041373253,
-0.01711464300751686,
0.014160349033772945,
-0.016984527930617332,
0.03003467619419098,
-0.00758744403719902,
0.005233217030763626,
0.00994902290403843,
0.009128937497735023,
-0.006755504757165909,
0.022013677284121513,
0.011413853615522385,
-0.004155799280852079,
0.02802557870745659,
-0.009573200717568398,
0.0005288880784064531,
0.010538375936448574,
-0.0057475632056593895,
-0.018937142565846443,
-0.004357219208031893,
-0.01552143320441246,
-0.0008857103530317545,
0.006040578708052635,
0.00005803932435810566,
-0.008379705250263214,
-0.007505550514906645,
0.009187530726194382,
-0.00647879671305418,
-0.001106293173506856,
0.018926052376627922,
-0.0046329195611178875,
-0.024634746834635735,
-0.003496546298265457,
0.008309189230203629,
-0.022020451724529266,
-0.011823628097772598,
0.00007975567132234573,
0.00971941463649273,
-0.06693345308303833,
0.019524602219462395,
0.016423199325799942,
0.006034842226654291,
0.00014703255146741867,
0.006742812693119049,
0.0017620340222492814,
-0.00025890395045280457,
-0.0066836983896791935,
0.007942832075059414,
0.00046494283014908433,
0.009036066010594368,
0.008374590426683426,
0.013380869291722775,
0.009480703622102737,
-0.0054055131040513515,
-0.020206168293952942,
0.011276568286120892,
0.01801116392016411,
-0.00015199626795947552,
0.024363446980714798,
-0.023804638534784317,
0.02871362864971161,
0.0019038785248994827,
-0.01884474791586399,
0.01911580190062523,
-0.022581560537219048,
-0.020584143698215485,
0.00031405355548486114,
-0.002829048316925764,
-0.016258886083960533,
-0.0010560564696788788,
0.003759221639484167,
-0.007843699306249619,
0.013143336400389671,
-0.013686900958418846,
0.026895351707935333,
0.01769307628273964,
-0.010211275890469551,
0.010638726875185966,
0.005299944430589676,
-0.013842028565704823,
0.040155284106731415,
0.020508132874965668,
0.015011702664196491,
-0.0193729680031538,
0.012236476875841618,
0.03211183473467827,
0.008313892409205437,
0.03816675394773483,
0.0074045960791409016,
0.0027203543577343225,
-0.021438919007778168,
0.007561253849416971,
-0.010108476504683495,
0.027781184762716293,
-0.04656878858804703,
-0.004890040494501591,
0.011039990931749344,
0.0051065776497125626,
0.021661564707756042,
-0.019546756520867348,
-0.019810223951935768,
0.0073594264686107635,
-0.006776029244065285,
-0.004230815917253494,
-0.0101030133664608,
0.0001306147314608097,
0.01293807104229927,
0.007357212249189615,
-0.002595036057755351,
-0.016760041937232018,
-0.024608895182609558,
0.0065728724002838135,
-0.01142382062971592,
-0.018612554296851158,
0.007247216068208218,
0.006068633869290352,
0.009090011939406395,
0.011911103501915932,
0.005929848644882441,
0.0007688573095947504,
0.005122091621160507,
0.018743231892585754,
0.0076101371087133884,
-0.01834733970463276,
-0.005041788797825575,
-0.005924068856984377,
-0.009855532087385654,
0.013937491923570633,
-0.011666432954370975,
0.007118230685591698,
-0.019432546570897102,
0.002772035077214241,
0.004457913339138031,
0.00447208434343338,
-0.02293361723423004,
-0.018682871013879776,
0.009500933811068535,
0.028040755540132523,
-0.005880420096218586,
0.0077703483402729034,
0.012374158948659897,
0.021953942254185677,
0.008825667202472687,
0.0005474850768223405,
-0.021454637870192528,
-0.02082224376499653,
0.014914462342858315,
0.032239727675914764,
-0.01047550980001688,
0.031039603054523468,
0.005530075170099735,
-0.007866956293582916,
0.06682858616113663,
-0.010383802466094494,
-0.01627439074218273,
-0.007557861506938934,
0.006299481261521578,
0.010088931769132614,
0.0028374847024679184,
0.011059168726205826,
-0.0019456436857581139,
-0.023656390607357025,
-0.004632557276636362,
0.016748923808336258,
0.004465711303055286,
0.009320844896137714,
-0.015968654304742813,
0.02776317484676838,
0.0034544914960861206,
0.009207245893776417,
0.009005974978208542,
-0.0004721602890640497,
0.020737163722515106,
0.010164623148739338,
0.03406276926398277,
0.014372467063367367,
0.026357898488640785,
-0.018666036427021027,
0.01794429123401642,
0.022495059296488762,
0.011138036847114563,
-0.012956246733665466,
0.010984282940626144,
-0.001541775418445468,
-0.006871601566672325,
-0.010819626972079277,
-0.013327036052942276,
-0.0035316026769578457,
0.012107927352190018,
-0.0056779286824166775,
0.011664016172289848,
-0.03954575955867767,
-0.015516660176217556,
0.0035945256240665913,
0.0053657591342926025,
-0.046409353613853455,
0.02251070737838745,
-0.020388362929224968,
-0.0025706631131470203,
0.01924341917037964,
0.009165169671177864,
0.00532169733196497,
-0.006168977357447147,
-0.011730426922440529,
-0.008536318317055702,
-0.010752649046480656,
-0.017893724143505096,
0.004595748148858547,
0.016145916655659676,
0.012866920791566372,
-0.015344377607107162,
0.007770845666527748,
-0.016228236258029938,
0.005293944850564003,
0.0070347413420677185,
0.004152548499405384,
0.003437176113948226,
-0.012925411574542522,
-0.013464173302054405,
0.02496989630162716,
-0.013498044572770596,
0.031173089519143105,
-0.013143638148903847,
0.010558972135186195,
0.011245985515415668,
0.021739793941378593,
0.0007364647462964058,
-0.014976385049521923,
-0.004590354859828949,
-0.05196937918663025,
-0.02205492928624153,
0.02604610286653042,
0.026197951287031174,
0.008946787565946579,
0.005331312771886587,
-0.012537455186247826,
0.013241292908787727,
0.006388464942574501,
0.031658243387937546,
-0.0037154038436710835,
-0.0043289996683597565,
0.006441032513976097,
0.017542032524943352,
0.006899761036038399,
-0.003537336364388466,
-0.007719321176409721,
-0.08125001192092896,
-0.0026262286119163036,
-0.014913162216544151,
-0.010127212852239609,
0.010464180260896683,
0.03815774992108345,
0.005364289507269859,
-0.018830813467502594,
0.008182352408766747,
0.014170657843351364,
0.012055369094014168,
0.005574176553636789,
-0.0017109736800193787,
0.011737611144781113,
-0.01130041852593422,
-0.0004326531197875738,
0.0026176210958510637,
-0.022273270413279533,
-0.005290408618748188,
-0.035005927085876465,
0.005911022890359163,
-0.0019328347407281399,
0.02158103697001934,
-0.021751079708337784,
0.016973096877336502,
0.03595910966396332,
0.023125801235437393,
-0.012909016571938992,
0.04848664626479149,
0.002588979434221983,
0.01897330954670906,
-0.011464130133390427,
0.019137216731905937,
0.00380878197029233,
0.02145056053996086,
-0.01698789745569229,
-0.028997110202908516,
0.005424710921943188,
-0.00636657141149044,
-0.005384937394410372,
-0.020257918164134026,
0.019903073087334633,
0.019637271761894226,
-0.004229479469358921,
0.007480451371520758,
0.02083754539489746,
0.02742946706712246,
-0.016322053968906403,
0.024976644665002823,
-0.0025632325559854507,
-0.026073284447193146,
-0.014933070167899132,
0.019952423870563507,
0.010924678295850754,
-0.009704087860882282,
-0.004938964731991291,
-0.005036010406911373,
0.004163624718785286,
-0.008724002167582512,
-0.013803978450596333,
-0.0021161988843232393,
-0.015983976423740387,
-0.013815579004585743,
0.001136312261223793,
-0.00863481592386961,
-0.010147824883460999,
0.01953870803117752,
-0.0021103806793689728,
-0.00014170794747769833,
0.004128460306674242,
0.01836932823061943,
0.02706882543861866,
-0.01432541012763977,
-0.017047300934791565,
0.044297851622104645,
0.0028283922001719475,
-0.014526838436722755,
-0.010768618434667587,
-0.03125351294875145,
-0.02734878472983837,
0.0010510445572435856,
-0.01764405518770218,
0.01497429795563221,
-0.0022560011129826307,
-0.005419739056378603,
0.010560058988630772,
0.013461986556649208,
0.02467467449605465,
0.007304569240659475,
-0.015517883002758026,
-0.0002838859800249338,
-0.010700197890400887,
-0.009006665088236332,
0.009575095027685165,
-0.016385670751333237,
0.00687381299212575,
-0.003219792153686285,
-0.01407556515187025,
0.024570461362600327,
0.008282593451440334,
0.007500763051211834,
-0.015144756995141506,
-0.009874600917100906,
-0.004516558721661568,
0.014461811631917953,
0.014990106225013733,
0.016886871308088303,
-0.014426598325371742,
-0.014969151467084885,
-0.004782702773809433,
0.00828062929213047,
0.011063894256949425,
-0.005831964313983917,
0.012013740837574005,
0.005287175998091698,
0.016612309962511063,
0.012091729789972305,
0.013864140026271343,
0.07183469831943512,
0.0008753563743084669,
-0.0036583025939762592,
0.005336955189704895,
-0.01902427338063717,
-0.017229463905096054,
-0.011680295690894127,
-0.0040306574665009975,
0.014918371103703976,
-0.03287442773580551,
0.013224823400378227,
-0.0033709544222801924,
-0.0230503361672163,
0.011008008383214474,
-0.0069649661891162395,
-0.0023229876533150673,
0.02121606096625328,
-0.02403045818209648,
0.0041903238743543625,
0.014283022843301296,
-0.005641803611069918,
-0.010087618604302406,
0.021749038249254227,
0.01589583232998848,
0.02040104754269123,
0.0064545730128884315,
0.014322851784527302,
-0.013530632480978966,
-0.015614992938935757,
0.004113954491913319,
0.015333184972405434,
0.006606644950807095,
-0.007978278212249279,
-0.015085777267813683,
0.02250891923904419,
-0.0256270170211792,
-0.02606777846813202,
0.021851900964975357,
0.007214391604065895,
-0.02175142616033554,
-0.012899558991193771,
-0.007474965415894985,
-0.006186211481690407,
0.005483899265527725,
-0.049285076558589935,
-0.0042180404998362064,
0.020138228312134743,
-0.006636954843997955,
-0.0018098826985806227,
-0.024893680587410927,
0.006542781367897987,
0.001884389203041792,
0.010780500248074532,
0.035048581659793854,
-0.014156453311443329,
0.0032473448663949966,
0.017834385856986046,
-0.01647935062646866,
0.013283242471516132,
-0.020419467240571976,
-0.0010689275804907084,
-0.0015623499639332294,
-0.0144963338971138,
-0.005468333140015602,
-0.011237072758376598,
-0.007759316824376583,
0.031276434659957886,
0.016582081094384193,
0.013033566996455193,
-0.00963585078716278,
-0.015242340974509716,
-0.008342769928276539,
0.005667882971465588,
-0.011744360439479351,
-0.013009624555706978,
-0.0004952107556164265,
0.0023062359541654587,
-0.0029867561534047127,
0.006290878169238567,
-0.0021019261330366135,
0.00977275799959898,
0.026867475360631943,
0.02186657302081585,
-0.013847033493220806,
0.020625781267881393,
-0.04168841987848282,
-0.027179524302482605,
-0.07460993528366089,
0.029946982860565186,
-0.020789964124560356,
-0.0017818454653024673,
0.016760122030973434,
0.018220558762550354,
-0.013575244694948196,
-0.004050687421113253,
-0.016687694936990738,
0.004064560402184725,
-0.010201305150985718,
0.012746674008667469,
-0.004639311693608761,
0.004899857100099325,
0.0143209807574749,
0.0179925337433815,
-0.003428451018407941,
0.005442783702164888,
-0.013719860464334488,
0.02451648749411106,
0.024524368345737457,
0.020238205790519714,
0.004454999230802059,
0.015758249908685684,
-0.013134835287928581,
-0.08070003986358643,
-0.023646019399166107,
0.013624168932437897,
0.006243589334189892,
-0.0078049348667263985,
0.004067126661539078,
0.01980978436768055,
-0.016912449151277542,
0.006306333467364311,
-0.014461020939052105,
-0.00973600335419178,
-0.0002215225249528885,
0.011472465470433235,
-0.003440323518589139,
-0.015404029749333858,
-0.00936942920088768,
0.020676523447036743,
0.010472768917679787,
-0.01694391295313835,
-0.018763795495033264,
0.003967924043536186,
0.011482547037303448,
-0.0038441577926278114,
-0.00006963778287172318,
-0.0025194294285029173,
-0.00014654546976089478,
-0.0018661150243133307,
0.01030887383967638,
0.004223315045237541,
0.003525489941239357,
-0.000638510100543499,
-0.011884143576025963,
-0.01605900377035141,
0.017102472484111786,
-0.01094507984817028,
-0.008351771160960197,
0.015307344496250153,
0.01680997759103775,
0.007044248282909393,
-0.010708087123930454,
-0.0014463369734585285,
-0.0034828779753297567,
-0.007981659844517708,
-0.005857840180397034,
0.0057132188230752945,
0.017241885885596275,
0.007732762023806572,
-0.015193554572761059,
0.006208185106515884,
-0.00034591369330883026,
0.014573881402611732,
0.011651406064629555,
0.029364464804530144,
0.020174307748675346,
0.011849822476506233,
0.011483913287520409,
-0.0038197559770196676,
0.019710350781679153,
0.004774346016347408,
0.014111184515058994,
0.014632080681622028,
-0.001482168911024928,
-0.011261086910963058,
0.0716712474822998,
-0.021312769502401352,
-0.006119127385318279,
-0.027473093941807747,
-0.019035756587982178,
0.00558494683355093,
-0.013020110316574574,
0.026327714323997498,
-0.03025750070810318,
0.004315800033509731,
0.01919417455792427,
-0.00920122116804123,
0.011628669686615467,
0.006853717379271984,
0.03414968401193619,
0.017267774790525436,
-0.008400946855545044,
-0.00999455712735653,
-0.007367989048361778,
-0.03774891048669815,
-0.037062130868434906,
0.004181993659585714,
0.002588247414678335,
-0.0062565128318965435,
-0.007220728788524866,
-0.009913429617881775,
-0.022675829008221626,
-0.015852108597755432,
-0.025910701602697372,
0.025168832391500473,
-0.05107380822300911,
0.027781207114458084,
0.003281448967754841,
-0.009689699858427048,
0.008487410843372345,
-0.010780842043459415,
-0.0037343213334679604,
0.007732739672064781,
0.006773241329938173,
0.02446034550666809,
-0.009580896236002445,
-0.0052854702807962894,
0.00020602426957339048,
-0.017496895045042038,
0.03162355720996857,
-0.009613150730729103,
0.005622272379696369,
0.0015878994017839432,
-0.006723702885210514,
0.017134610563516617,
-0.033844031393527985,
0.013165654614567757,
-0.011638486757874489,
-0.004492887761443853,
0.009831082075834274,
-0.00619115587323904,
-0.002999803749844432,
0.01734599843621254,
-0.0294770710170269,
-0.022681541740894318,
0.022013144567608833,
-0.007147851400077343,
-0.019310131669044495,
-0.014800234697759151,
0.002022291999310255,
0.025742795318365097,
0.017437949776649475,
-0.015751836821436882,
-0.03836861252784729,
0.012660099193453789,
0.0005275742150843143,
-0.0032981703989207745,
0.0053791385143995285,
-0.027777690440416336,
0.012917526997625828,
0.007183958776295185,
0.01514478214085102,
0.00811063777655363,
0.02902805805206299,
0.010947618633508682,
-0.001894927816465497,
-0.027896013110876083,
0.014562902972102165,
0.006429824512451887,
0.012046805582940578,
0.0025981739163398743,
-0.0035257672425359488,
-0.011227419599890709,
0.0010893193539232016,
-0.0015259626088663936,
0.007480533327907324,
0.008755454793572426,
0.005080698523670435,
0.02476334758102894,
0.009562255814671516,
0.03480738028883934,
0.004137421492487192,
0.003107717027887702,
0.011608246713876724,
0.01833687536418438,
-0.0050133466720581055,
-0.01067692693322897,
-0.013162107206881046,
-0.009348435327410698,
-0.013941763900220394,
-0.006220674142241478,
-0.003805628977715969,
0.019871052354574203,
0.008213914930820465,
-0.010467042215168476,
-0.0002448917366564274,
-0.006661977618932724,
0.03997072950005531,
-0.0009811125928536057,
0.013698117807507515,
-0.017961563542485237,
-0.0020341509953141212,
0.03326357528567314,
-0.006490953266620636,
-0.011029642075300217,
-0.044485293328762054,
-0.018295133486390114,
-0.002148793777450919,
0.020116690546274185,
0.0021096235141158104,
-0.016568660736083984,
-0.007366858422756195,
0.010594082996249199,
0.0008377463091164827,
-0.006132129114121199,
0.02055204287171364,
0.0027842496056109667,
-0.004116734489798546,
0.0034604445099830627,
-0.028705302625894547,
-0.006351779215037823,
0.000014924444258213043,
0.04301159083843231,
0.008098230697214603,
-0.009522558189928532,
0.006053037941455841,
-0.02034536376595497,
0.005076696164906025,
-0.010303264483809471,
0.008994225412607193,
-0.021181026473641396,
-0.00795871764421463,
0.017479151487350464,
0.013514642603695393,
-0.00564813707023859,
-0.0010625608265399933,
-0.00550237949937582,
0.01634700782597065,
-0.011665663681924343,
0.012035978958010674,
-0.00431810412555933,
0.003375330939888954,
-0.013682825490832329,
0.006022099405527115,
-0.010963336564600468,
-0.023574348539114,
0.009895850904285908,
-0.0016985645052045584,
0.0012033339589834213,
0.0041433293372392654,
0.009447727352380753,
-0.016671787947416306,
0.02725006639957428,
0.02091260254383087,
0.02613411471247673,
0.017584383487701416,
0.02028706669807434,
0.014221934601664543,
0.02024979516863823,
-0.026757195591926575,
-0.006118128076195717,
-0.009288550354540348,
0.0010904143564403057,
-0.024301845580339432,
0.009630389511585236,
-0.03914843499660492,
-0.018289459869265556,
0.008085905574262142,
-0.00834053847938776,
-0.001481359824538231,
-0.02130753919482231,
-0.018250327557325363,
-0.00745548726990819,
-0.00943514984101057,
0.006264813244342804,
-0.011007399298250675,
-0.03718802332878113,
-0.005885242018848658,
0.006090610288083553,
-0.005324371159076691,
0.023483827710151672,
-0.006365546956658363,
-0.031796738505363464,
-0.004438050091266632,
0.01601816713809967,
-0.003171727526932955,
-0.014894572086632252
] | [
0.0927324891090393,
-0.015274166129529476,
-0.454330712556839,
-0.07091215252876282,
0.10327454656362534,
0.24082757532596588,
0.0827438160777092,
0.18501964211463928,
-0.16128498315811157,
-0.33548668026924133,
0.33393594622612,
-0.046776559203863144,
-0.21858268976211548,
0.4963485300540924,
0.19189965724945068,
0.9148316383361816,
0.3855744004249573,
0.5986200571060181,
-0.4594918191432953,
-0.2996028661727905,
-0.5905030965805054,
-0.5163090825080872,
0.6608786582946777,
0.12958352267742157,
-0.12346146255731583,
-0.11921290308237076,
0.6270193457603455,
0.22898584604263306,
-0.16630041599273682,
-0.31897568702697754,
0.2662593424320221,
0.5507775545120239,
0.8666438460350037,
-0.5469430685043335,
-0.036054372787475586,
-0.3203774094581604,
-0.0062119984067976475,
-0.15046337246894836,
-0.18667450547218323,
-0.4375702142715454,
-0.45335307717323303,
-0.028032632544636726,
0.18661725521087646,
0.31424590945243835,
0.30630818009376526,
0.018900157883763313,
-1.0275286436080933,
0.4754534363746643,
-0.3101501762866974,
0.09952031075954437,
0.5988504886627197,
-0.3482944667339325,
0.7524724006652832,
0.05385894328355789,
0.24635758996009827,
0.08489569276571274,
-1.002228021621704,
-0.25374680757522583,
0.2610960900783539,
-0.4343147277832031,
0.21933431923389435,
0.050160713493824005,
-0.03500017896294594,
0.1022413969039917,
-0.016635553911328316,
0.27297788858413696,
0.05073053389787674,
-0.029660191386938095,
-0.5203484296798706,
0.5273304581642151,
0.19153152406215668,
-0.7101935148239136,
-0.18844033777713776,
-0.1321323812007904,
-0.0964822992682457,
0.2026832103729248,
-0.3250323534011841,
-0.4796239733695984,
0.3781298100948334,
-0.09814541786909103,
-0.014592976309359074,
-0.15088613331317902,
0.2886292040348053,
0.139451801776886,
0.3175515830516815,
0.22764047980308533,
-0.27101007103919983,
0.652894139289856,
-0.2993389666080475,
0.1045546606183052,
-0.05633210763335228,
-0.05872856080532074,
0.5548064708709717,
0.6568140983581543,
-0.018051035702228546,
0.28424936532974243,
0.01821686141192913,
0.18691526353359222,
0.29565832018852234,
-0.11322826892137527,
-0.45944052934646606,
-0.06242430955171585,
-0.22715222835540771,
0.05120876058936119,
-0.20929493010044098,
0.030829451978206635,
-0.27382346987724304,
-0.15354256331920624,
-0.3822082281112671,
0.08215917646884918,
-0.3087385892868042,
0.15106035768985748,
-0.15888305008411407,
-0.5808849334716797,
-0.47422581911087036,
0.15133988857269287,
0.36830446124076843,
-0.35614943504333496,
0.115338534116745,
-0.3531775176525116,
-0.4895550608634949,
0.5619377493858337,
-0.23363491892814636,
0.351741224527359,
-0.5383586883544922,
0.10983220487833023,
-0.04807451739907265,
0.10726333409547806,
0.08004268258810043,
0.5238468647003174,
0.44556403160095215,
0.7126994729042053,
-0.06046910211443901,
-0.04775286838412285,
0.08040789514780045,
-0.1382887065410614,
-0.5243701934814453,
0.047983262687921524,
0.9315354228019714,
0.19200929999351501,
-0.4982951879501343,
-0.7123333215713501,
-0.6575925946235657,
0.325682669878006,
-0.5268047451972961,
-0.20593875646591187,
-0.08305225521326065,
0.49892911314964294,
0.12138791382312775,
-0.10091078281402588,
0.14680317044258118,
-0.342813104391098,
-0.8170527219772339,
-0.22564150393009186,
-0.2937501072883606,
-0.13929738104343414,
-0.00982800591737032,
-0.7263749837875366,
-0.13339613378047943,
0.09781225025653839,
0.2937314212322235,
-0.026668816804885864,
-0.3787694573402405,
0.05049557611346245,
0.7867109775543213,
-0.48842617869377136,
-0.399176687002182,
0.05978849157691002,
-0.009998191148042679,
0.35317811369895935,
-0.4284052848815918,
-0.1781260371208191,
-0.1426946520805359,
-0.8112193942070007,
0.012061355635523796,
0.20891688764095306,
0.3730423152446747,
-0.28238072991371155,
0.1605813056230545,
0.09707313776016235,
-0.5712257623672485,
0.16282637417316437,
0.014565701596438885,
-0.2547532320022583,
0.4532153606414795,
0.3201346695423126,
0.0850004106760025,
0.0677403062582016,
0.2988836169242859,
0.20538058876991272,
-0.2795000970363617,
-0.7217183113098145,
0.9189416170120239,
-0.21557125449180603,
1.2031855583190918,
-0.14852960407733917,
-0.11668702960014343,
1.1338205337524414,
0.5859560966491699,
-0.29296284914016724,
-0.1902027577161789,
0.3696739077568054,
0.6929700374603271,
-0.5738492608070374,
-1.1698445081710815,
0.26868686079978943,
0.11688181012868881,
-0.46121931076049805,
0.2996625304222107,
0.06959786266088486,
0.31685182452201843,
-0.3416154384613037,
0.3217740058898926,
-0.4038209021091461,
0.2874295115470886,
0.010677117854356766,
-0.01198981050401926,
0.1612333208322525,
0.22339937090873718,
-0.42215830087661743,
0.44167816638946533,
-0.8401114344596863,
0.30462637543678284,
0.6933553218841553,
-0.16115763783454895,
0.43032100796699524,
0.15225771069526672,
-0.09215974807739258,
0.982964813709259,
-0.54855877161026,
0.5585103631019592,
-0.07904375344514847,
0.3815474510192871,
-0.6622223854064941,
0.05248842015862465,
0.22588883340358734,
-0.2012026309967041,
-0.2897668480873108,
0.25583741068840027,
0.20639756321907043,
0.011047548614442348,
0.38116198778152466,
-0.7384623885154724,
0.392963707447052,
-0.013648438267409801,
-0.630035936832428,
-0.2490423321723938,
0.2936619222164154,
-0.1604735404253006,
0.18020303547382355,
0.6257851123809814,
0.4423406422138214,
0.3377550542354584,
-0.5385079979896545,
0.1345839947462082,
0.18770462274551392,
-0.26629340648651123,
-0.4559729993343353,
0.4349139928817749,
-0.7400257587432861,
-0.41434967517852783,
0.4274980425834656,
0.3445304334163666,
0.3439911901950836,
0.24073585867881775,
-0.3745335042476654,
-0.8266820907592773,
-0.1551598310470581,
0.7548068761825562,
0.273921400308609,
1.0600210428237915,
0.6435554027557373,
-0.6274208426475525,
-0.14277267456054688,
-0.0535288006067276,
-0.15609610080718994,
-0.28526046872138977,
0.7466498017311096,
-0.7281466722488403,
-0.31642693281173706,
-0.3936256766319275,
0.563948929309845,
0.6378462910652161,
-0.44775599241256714,
-0.14190354943275452,
0.04626580700278282,
0.19189605116844177,
-0.21127015352249146,
-0.6378993988037109,
-0.2570751905441284,
-0.20340731739997864,
0.1753142923116684,
-0.2186427265405655,
0.458196222782135,
0.43809962272644043,
-0.13001781702041626,
-0.14720363914966583,
0.5936327576637268,
0.7973136305809021,
-0.5885051488876343,
0.0015839306870475411,
0.3855434060096741,
-0.7372817397117615,
-0.056970562785863876,
-0.05542334169149399,
0.04220397770404816,
-0.2715795934200287,
-0.1199357658624649,
-5.928807258605957,
0.11593205481767654,
-0.40107446908950806,
0.11839351803064346,
-0.24322205781936646,
-0.0932428240776062,
0.9773592352867126,
-0.2268497794866562,
0.1442278027534485,
0.16961009800434113,
0.297137975692749,
0.7942488789558411,
0.5557808876037598,
0.0470680333673954,
-0.2613216042518616,
0.08397617936134338,
-0.06680873781442642,
-0.668563187122345,
0.19576013088226318,
0.17183369398117065,
0.3708627223968506,
-0.21826675534248352,
-0.3894483149051666,
0.7849090695381165,
0.1875145584344864,
0.1624455451965332,
-0.9292694926261902,
0.652894914150238,
-0.24979394674301147,
-0.17921316623687744,
0.2590329051017761,
-0.3654632270336151,
-0.14130522310733795,
0.028851784765720367,
0.1913098841905594,
-0.10404203832149506,
-0.37346863746643066,
-0.4035021960735321,
-0.17954511940479279,
-0.045561615377664566,
-0.1339186131954193,
-0.40587854385375977,
-0.26369595527648926,
0.13356642425060272,
-0.2993256449699402,
-0.2101803421974182,
0.23497414588928223,
-0.22072167694568634,
-0.029607070609927177,
0.9280573129653931,
0.2607286274433136,
-0.20582593977451324,
0.5730440020561218,
0.872779369354248,
0.5268309712409973,
-0.004900201223790646,
0.11531372368335724,
0.04272954910993576,
0.031042538583278656,
0.03664316236972809,
-0.5092934966087341,
-0.19315402209758759,
0.0932236835360527,
-0.687830924987793,
-0.1797008514404297,
0.5259464383125305,
-0.5434556603431702,
0.050776317715644836,
0.30960148572921753,
-0.10200698673725128,
-0.5468931198120117,
0.2997661530971527,
0.10898973792791367,
-0.6541084051132202,
0.5710232853889465,
-0.420675128698349,
0.14370746910572052,
0.5000181794166565,
-0.13243354856967926,
-0.2401016354560852,
0.1347440928220749,
-0.15407836437225342,
0.02318788506090641,
-0.023898690938949585,
0.033829465508461,
-0.5921956896781921,
0.08656398952007294,
-0.168621227145195,
0.06732876598834991,
0.07111157476902008,
0.15789653360843658,
-0.06940092891454697,
-0.289767324924469,
0.14485624432563782,
0.504300594329834,
0.6339071393013,
-0.08571330457925797,
0.5485631227493286,
0.8630120754241943,
0.34681063890457153,
1.09992516040802,
0.025451788678765297,
-0.3402578830718994,
-0.4472541809082031,
0.15902794897556305,
-0.2563047707080841,
-0.1294279247522354,
-0.2996334135532379,
0.46915432810783386,
-0.9084462523460388,
0.26916301250457764,
-0.16738103330135345,
-0.6914111375808716,
-0.3504990339279175,
0.5526325702667236,
-0.35198548436164856,
0.10747778415679932,
0.16731300950050354,
0.6154252886772156,
-0.14012163877487183,
0.5948539972305298,
0.405834436416626,
-0.538943886756897,
0.4751107692718506,
0.18847879767417908,
-0.23231428861618042,
0.42364636063575745,
0.7021170258522034,
-0.8136788010597229,
-0.2638104557991028,
-0.08531490713357925,
0.1413024365901947,
-0.19821450114250183,
-0.07722106575965881,
0.3112342059612274,
-0.16791915893554688,
-0.49947673082351685,
-0.23347124457359314,
-0.12300243228673935,
0.034614525735378265,
-0.4024496078491211,
-0.3002481758594513,
-0.18007038533687592,
0.28981077671051025,
0.11748289316892624,
-0.0224208552390337,
-0.1584353744983673,
-0.20014996826648712,
-0.370937705039978,
-0.3503342568874359,
-0.009068889543414116,
-0.2599245309829712,
0.39135870337486267,
0.2528744041919708,
-0.6240360736846924,
0.3297102153301239,
0.35923415422439575,
0.3513681888580322,
-0.16440211236476898,
-0.8450512290000916,
0.08440923690795898,
-0.2965747117996216,
-1.2007317543029785,
-0.09856405109167099,
-0.12578250467777252,
-0.48750656843185425,
0.1844244748353958,
-0.3723756968975067,
0.04203660041093826,
0.2389277219772339,
-0.48911404609680176,
-0.20067539811134338,
0.03534257784485817,
-0.0831308662891388,
0.38456812500953674,
-0.1286434531211853,
-0.5135595798492432,
-0.07739418745040894,
-0.11802472174167633,
0.14290831983089447,
0.10453055799007416,
-0.15048086643218994,
-0.0542670339345932,
0.3235115110874176,
0.30065855383872986,
0.5693075060844421,
-0.1036284789443016,
-0.11063989996910095,
-0.8579476475715637,
-0.1990509331226349,
0.047465745359659195,
-0.1089373454451561,
0.37311217188835144,
0.15273520350456238,
-0.23420482873916626,
-0.18659228086471558,
0.1606665998697281,
-0.1882721185684204,
-0.11040327697992325,
-0.3367031514644623,
-0.14839795231819153,
0.30355104804039,
-0.03584606945514679,
0.557262122631073,
0.3684297502040863,
-0.3496392071247101,
0.27081042528152466,
-0.39154529571533203,
-0.3263928294181824,
-0.1339924931526184,
0.12354870140552521,
-0.15861305594444275,
0.3492947816848755,
0.5186537504196167,
-0.21607857942581177,
0.2609829008579254,
0.18292294442653656,
-0.2033284306526184,
0.26214107871055603,
0.19434626400470734,
0.21385684609413147,
0.22204214334487915,
-0.10273288190364838,
-0.0984579548239708,
-0.6174379587173462,
0.5713921785354614,
0.5809296369552612,
-0.6656001210212708,
-0.4585150182247162,
0.3448545038700104,
-0.15328219532966614,
-0.09406440705060959,
0.22187745571136475,
-0.021564064547419548,
-0.4534912109375,
-0.22149905562400818,
0.18051673471927643,
0.03599165007472038,
-0.2694753408432007,
0.5261313319206238,
0.31188637018203735,
0.10828197002410889,
-0.1885775923728943,
-0.13870222866535187,
0.1197318360209465,
-0.026299405843019485,
0.19512306153774261,
-0.17752474546432495,
-0.6601778864860535,
0.1287759244441986,
0.4515703320503235,
-0.2504431903362274,
-0.0023828318808227777,
-0.011511547490954399,
0.7949590086936951,
-0.1743031144142151,
-0.1319013237953186,
-0.15419533848762512,
-0.005299845710396767,
0.20059144496917725,
-0.15761727094650269,
0.2005457580089569,
-0.23838932812213898,
0.23436616361141205,
0.034450601786375046,
-0.019575100392103195,
-0.27805086970329285,
-0.8148233890533447,
0.1856064349412918,
-0.5134454369544983,
0.10510808974504471,
0.20802225172519684,
1.0023794174194336,
0.5997253656387329,
-0.023455699905753136,
0.4661196172237396,
-0.41468995809555054,
-0.5177252292633057,
-0.34379521012306213,
0.44337591528892517,
-0.34284326434135437,
-0.4295627176761627,
-0.021939527243375778,
-0.03561411798000336,
0.12829910218715668,
-0.20611660182476044,
-0.06667695194482803,
-0.12558813393115997,
-0.18710651993751526,
-0.5198681950569153,
0.18575336039066315,
-0.037917908281087875,
-0.5225027203559875,
-0.4844423532485962,
0.15325668454170227,
0.11396544426679611,
0.09065121412277222,
0.29426026344299316,
0.15173028409481049,
-0.47241199016571045,
-0.4687078595161438,
0.553252100944519,
0.7943194508552551,
-0.05580519884824753,
0.3144543170928955,
0.37466126680374146,
0.18493616580963135,
0.3949563205242157,
-0.23886485397815704,
-0.14620263874530792,
0.22077375650405884,
-0.2874752879142761,
0.13544997572898865,
0.5152174234390259,
-0.3846915364265442,
0.1781080663204193,
-0.39880698919296265,
-0.1349296271800995,
0.4338914155960083,
0.22531764209270477,
0.3030921220779419,
0.7496117353439331,
0.6378421187400818,
0.14917808771133423,
-0.18590310215950012,
0.24867752194404602,
-0.09967957437038422,
0.23094810545444489,
0.18915264308452606,
0.6348147392272949,
0.5008634924888611,
0.43077191710472107,
-0.2853635847568512,
0.5940036773681641,
0.30409109592437744,
0.383550226688385,
-0.07296603918075562,
-0.5790513157844543,
-0.17709095776081085,
0.397811621427536,
0.5443865060806274,
0.07110699266195297,
0.265487939119339,
0.16812488436698914,
0.0046341088600456715,
0.5579531192779541,
-0.1247796043753624,
-0.08700063079595566,
0.28489845991134644,
-0.26127827167510986,
-0.03271961957216263,
-0.015338297933340073,
-0.14060981571674347,
-0.13470229506492615,
-0.6240149140357971,
0.6287182569503784,
0.4585796594619751,
-0.426550030708313,
-0.5220563411712646,
0.4424285292625427,
-0.5379034280776978,
0.30302923917770386,
-0.36266592144966125,
0.2798407971858978,
-0.19049768149852753,
-0.2713412046432495,
0.07780265063047409,
-0.189849391579628,
0.0437081977725029,
0.003526378655806184,
0.1837610900402069,
-0.8389367461204529,
-0.4862751066684723,
-0.0828527957201004,
0.43114879727363586,
-0.026225687935948372,
-0.026915332302451134,
0.002563050715252757,
0.1148606687784195,
0.5075977444648743,
-0.5690487027168274,
0.043109018355607986,
-0.18994897603988647,
-0.1987731158733368,
-0.012645176611840725,
-0.07080494612455368,
-0.2366710603237152,
0.21308225393295288,
0.312814325094223,
-0.0893653854727745,
-0.17925171554088593,
-0.4430096745491028,
-0.13514375686645508,
0.3287632465362549,
0.1762266755104065,
-0.3005458116531372,
0.05121305584907532,
0.04666975513100624,
0.10078383982181549,
0.21622908115386963,
-0.3481922745704651,
0.023168692365288734,
-0.27795711159706116,
0.1823812872171402,
-0.8124253153800964,
0.38534778356552124,
0.09778062999248505,
0.12885518372058868,
-0.7262083292007446,
0.18359419703483582,
0.5905949473381042,
0.7752801179885864,
-0.24050691723823547,
0.020398277789354324,
0.18181706964969635,
-0.2721453607082367,
0.646430492401123,
-0.4777037501335144,
-0.518884003162384,
-0.5900899171829224,
-0.12328958511352539,
-0.6262471079826355,
0.26601600646972656,
-0.37302300333976746,
-0.27928391098976135,
0.2548234164714813,
0.1252618134021759,
0.530680239200592,
-0.23125514388084412,
0.07464631646871567,
-0.15602506697177887,
0.3778647482395172,
-0.7494182586669922,
0.24853229522705078,
-0.38182780146598816,
-0.026329340413212776,
0.23591484129428864,
0.07825812697410583,
-0.06544215977191925,
0.11938266456127167,
0.25243639945983887,
-0.9106927514076233,
-0.21276408433914185,
-0.5106656551361084,
0.18590496480464935,
0.5627468824386597,
0.051023706793785095,
0.049894336611032486,
-0.8393486142158508,
0.3525136113166809,
-0.14897261559963226,
-0.5152381062507629,
-0.04454601928591728,
0.22201237082481384,
-0.2989296615123749,
-0.6315051913261414,
-0.2157357633113861,
-0.176312655210495,
-0.21988624334335327,
0.12478242814540863
] |
BACKGROUND: Mycobacterium tuberculosis (MTB) is a major cause of morbidity and mortality in the world. To combat against this pathogen, immune cells release cytokines including tumor necrosis factor-α (TNF-α), which is pivotal in the development of protective granulomas. Our previous results showed that Bacillus Calmette Guerin (BCG), a mycobacterium used as a model to investigate the immune response against MTB, stimulates the induction of TNF-α via mitogen-activated protein kinase (MAPK) in human blood monocytes. Since MAPK phosphatase-1 (MKP-1) is known to regulate MAPK activities, we examined whether MKP-1 plays a role in BCG-induced MAPK activation and cytokine expression. RESULTS: Primary human blood monocytes were treated with BCG and assayed for MKP-1 expression. Our results demonstrated that following exposure to BCG, there was an increase in the expression of MKP-1. Additionally, the induction of MKP-1 was regulated by p38 MAPK and extracellular signal-regulated kinase 1 and 2 (ERK1/2). Surprisingly, when MKP-1 expression was blocked by its specific siRNA, there was a significant decrease in the levels of phospho-MAPK (p38 MAPK and ERK1/2) and TNF-α inducible by BCG. CONCLUSIONS: Since TNF-α is pivotal in granuloma formation, the results indicated an unexpected positive function of MKP-1 against mycobacterial infection as opposed to its usual phosphatase activity. | [
0.0024601651821285486,
0.002990621840581298,
-0.015002269297838211,
0.0076227919198572636,
0.025122368708252907,
-0.004048768896609545,
0.009814532473683357,
0.011221629567444324,
-0.013451606035232544,
-0.029843080788850784,
-0.009542074054479599,
0.008668007329106331,
-0.01865086518228054,
0.02218398079276085,
-0.061804454773664474,
0.0010609612800180912,
-0.02585269883275032,
0.033311404287815094,
0.01581132411956787,
0.024997130036354065,
-0.01262506004422903,
-0.013231510296463966,
0.0105045260861516,
-0.014293983578681946,
0.029420506209135056,
0.033722132444381714,
-0.028688160702586174,
0.014771245419979095,
-0.011786408722400665,
0.0033096882980316877,
-0.028862524777650833,
0.021621033549308777,
0.022837312892079353,
-0.007673320360481739,
0.012578031048178673,
-0.002510904800146818,
-0.0044120908714830875,
0.02806183323264122,
-0.00432999525219202,
-0.0039830454625189304,
0.011783826164901257,
-0.017230868339538574,
0.0011906404979526997,
-0.010172927752137184,
-0.0064782435074448586,
-0.011528609320521355,
0.004469895735383034,
-0.017623208463191986,
0.013881762512028217,
0.008373239077627659,
-0.0007903965888544917,
-0.04279858246445656,
-0.016530366614460945,
0.010128163732588291,
-0.006208859384059906,
-0.0028214924968779087,
0.017289360985159874,
-0.032705776393413544,
-0.025129716843366623,
0.009154134429991245,
0.03599422425031662,
-0.014518546871840954,
0.014682835899293423,
-0.015046419575810432,
0.004076378419995308,
-0.06690768897533417,
0.03683101758360863,
-0.01317504234611988,
0.00837574154138565,
0.010011277161538601,
-0.006071201525628567,
0.011685220524668694,
0.0020259548909962177,
-0.024474162608385086,
-0.012790276668965816,
-0.018645018339157104,
-0.019162287935614586,
0.013619212433695793,
0.017075665295124054,
0.009674564935266972,
-0.010067379102110863,
-0.012619519606232643,
-0.014543934725224972,
0.02707696333527565,
0.004777104593813419,
0.02716252952814102,
-0.033393993973731995,
-0.02260918915271759,
-0.015359709039330482,
0.002577887149527669,
0.005997583270072937,
-0.017469514161348343,
-0.0037184376269578934,
0.0063406964763998985,
0.006324020680040121,
-0.0009481944143772125,
-0.009045145474374294,
-0.02051467075943947,
0.0020618648268282413,
0.003655492328107357,
-0.014514146372675896,
-0.003491729497909546,
0.011174755170941353,
0.02392936311662197,
0.0215680543333292,
0.0055933427065610886,
-0.01664808951318264,
0.01941879838705063,
0.025096451863646507,
0.015355318784713745,
-0.020666293799877167,
0.00846183393150568,
0.0052758269011974335,
0.018626824021339417,
0.027895744889974594,
0.00633844593539834,
-0.02201882191002369,
-0.0055619897320866585,
0.014257877133786678,
0.010265353135764599,
0.04878735914826393,
-0.005125619471073151,
-0.005227372050285339,
-0.009144107811152935,
0.0031174547038972378,
0.0004962305538356304,
-0.020131893455982208,
0.0026524891145527363,
0.010701056569814682,
-0.005452796816825867,
-0.00686369463801384,
-0.006166842300444841,
0.008473986759781837,
-0.0028048150707036257,
0.0015446720644831657,
-0.0011925222352147102,
-0.01604374125599861,
-0.02225896343588829,
0.003487922251224518,
0.004122193902730942,
-0.003909704741090536,
0.0048730382695794106,
-0.001410648343153298,
0.004237280692905188,
-0.005285640712827444,
-0.0023377505131065845,
-0.01823836751282215,
-0.006046062335371971,
0.03019995614886284,
-0.005699191242456436,
0.009132490493357182,
0.005850155837833881,
-0.017640164121985435,
-0.0019163014367222786,
-0.013368360698223114,
-0.00069218291901052,
-0.010962491855025291,
-0.03495735675096512,
0.002049506176263094,
-0.008052047342061996,
0.010788539424538612,
-0.04190964624285698,
0.029336612671613693,
0.009581014513969421,
0.011937161907553673,
-0.003973002545535564,
-0.013721230439841747,
-0.0015399368712678552,
0.023883558809757233,
0.008957669138908386,
0.0017877189675346017,
-0.007701493799686432,
-0.020297987386584282,
0.009954378008842468,
-0.01284055970609188,
0.00814508181065321,
0.024190960451960564,
0.007426661439239979,
-0.01154324971139431,
0.06597694754600525,
0.0250086672604084,
0.007303406950086355,
-0.00018521363381296396,
-0.009199083782732487,
0.006562807597219944,
-0.013164022006094456,
0.016188424080610275,
-0.01119915209710598,
-0.01539634820073843,
0.001397450570948422,
0.03157686069607735,
-0.014174682088196278,
-0.0028603875543922186,
-0.0011214115656912327,
0.0007269801571965218,
0.0028944523073732853,
0.009182712994515896,
0.005572531372308731,
0.02010321617126465,
0.006244654767215252,
0.0115378238260746,
-0.012705720029771328,
0.014789445325732231,
-0.010271074250340462,
-0.01113362517207861,
0.00988013669848442,
0.019665196537971497,
-0.021508697420358658,
-0.012185029685497284,
-0.029677879065275192,
-0.0025590748991817236,
-0.019580364227294922,
0.012331738136708736,
-0.00814035627990961,
-0.004941101185977459,
0.00834469124674797,
0.011986929923295975,
0.029467947781085968,
-0.03771455958485603,
-0.010312920436263084,
-0.0011415837798267603,
-0.0013331484515219927,
-0.024077804759144783,
0.0006231078878045082,
-0.006008051801472902,
0.03132494166493416,
0.008175168186426163,
0.011608588509261608,
-0.008790416643023491,
0.011898543685674667,
-0.006399259902536869,
0.006680114194750786,
-0.012420155107975006,
0.014652887359261513,
-0.021464863792061806,
0.007673646789044142,
0.013008100911974907,
-0.0030068247579038143,
0.0054283044300973415,
-0.018174322322010994,
0.021489150822162628,
0.01840364560484886,
0.04368561506271362,
0.01599385030567646,
-0.011219283565878868,
-0.035554613918066025,
0.015018554404377937,
0.010849254205822945,
0.018223654478788376,
-0.005546834319829941,
0.01246659830212593,
-0.019267374649643898,
0.00527856033295393,
-0.0005414462648332119,
0.024089694023132324,
-0.017860397696495056,
0.0042680734768509865,
0.006603988818824291,
0.02700883336365223,
0.004236758220940828,
0.004805220291018486,
0.008195793256163597,
-0.004435836337506771,
0.02945179119706154,
0.012394719757139683,
0.007592536509037018,
0.03445234149694443,
0.01663823425769806,
-0.005628818646073341,
0.004900709725916386,
0.006674844305962324,
-0.005014310125261545,
-0.002494058571755886,
-0.08224625885486603,
-0.008911626413464546,
-0.015104803256690502,
-0.023344572633504868,
0.005563194863498211,
0.02886318415403366,
-0.0057350341230630875,
-0.016153305768966675,
-0.006410310044884682,
0.003836815245449543,
-0.004989218898117542,
-0.0073170047253370285,
-0.00225584814324975,
-0.007322276011109352,
-0.01470884308218956,
-0.005800261162221432,
0.01692238450050354,
-0.018703244626522064,
0.008517972193658352,
-0.024372143670916557,
0.024399900808930397,
-0.004225256387144327,
0.04157118499279022,
-0.0030214358121156693,
-0.000007520196959376335,
-0.0001474800519645214,
0.011368419043719769,
-0.012098551727831364,
0.005497507750988007,
0.0036931480281054974,
0.019239522516727448,
0.008739576674997807,
0.02402907982468605,
0.004761009477078915,
0.020530959591269493,
0.010630302131175995,
0.005207568407058716,
-0.005577667150646448,
-0.023247169330716133,
0.032855961471796036,
-0.023032192140817642,
0.005862779449671507,
0.0026568970642983913,
-0.014004645869135857,
0.027064939960837364,
0.013599799014627934,
-0.021062195301055908,
-0.0028331889770925045,
0.010288880206644535,
0.0028075585141777992,
-0.034302473068237305,
0.00224574888125062,
0.017192089930176735,
0.017132997512817383,
-0.019210217520594597,
-0.01705111563205719,
-0.02756144106388092,
-0.020308924838900566,
-0.009225849993526936,
-0.008107309229671955,
-0.00643307575955987,
-0.032543718814849854,
0.00853520818054676,
0.023163245990872383,
-0.011188588105142117,
-0.007648303639143705,
0.011637527495622635,
0.01621469110250473,
-0.03301912546157837,
0.02526203915476799,
-0.011880716308951378,
0.03270033746957779,
-0.00392997357994318,
-0.007302790880203247,
0.0043137772008776665,
-0.0004109850851818919,
-0.011797893792390823,
-0.003964926116168499,
-0.0012275977060198784,
-0.01390036754310131,
0.00802273117005825,
0.01812668703496456,
0.0021826252341270447,
-0.018493030220270157,
-0.006399701349437237,
-0.020302824676036835,
0.009467432275414467,
0.03743700683116913,
0.012356915511190891,
-0.013329838402569294,
-0.0028280485421419144,
0.010125084780156612,
-0.03320879489183426,
0.013418077491223812,
0.004915147554129362,
-0.004620118997991085,
-0.018660934641957283,
0.008458863943815231,
-0.004450409673154354,
0.0071327416226267815,
-0.024367207661271095,
-0.0033426410518586636,
-0.025949645787477493,
-0.006110950373113155,
-0.013916702009737492,
0.016749955713748932,
0.024409104138612747,
-0.005220590624958277,
-0.009423329494893551,
-0.006368399132043123,
-0.0015340624377131462,
0.0194782093167305,
-0.010098138824105263,
0.022298328578472137,
0.01274541113525629,
-0.0018193466821685433,
-0.002763104159384966,
-0.018317418172955513,
0.07214481383562088,
-0.016471976414322853,
-0.00028609624132514,
-0.01672106795012951,
-0.014355504885315895,
-0.015123988501727581,
0.00629787053912878,
0.02715522237122059,
0.009375682100653648,
0.022974232211709023,
0.014734485186636448,
-0.014670124277472496,
0.019178440794348717,
0.02065867744386196,
0.009203406982123852,
0.013066482730209827,
0.016339190304279327,
-0.022578565403819084,
-0.0036108235362917185,
-0.00855870358645916,
0.014511464163661003,
-0.02728135511279106,
-0.01509613636881113,
-0.006212133914232254,
0.0030211990233510733,
-0.004836167674511671,
0.005942986812442541,
-0.010076267644762993,
-0.027509020641446114,
0.008710244670510292,
0.0051947166211903095,
-0.020836900919675827,
-0.009265139698982239,
-0.006063232198357582,
0.025800906121730804,
0.015478165820240974,
0.016201641410589218,
0.010242209769785404,
0.0010458080796524882,
0.0019368992652744055,
-0.0223400816321373,
-0.02204536832869053,
0.008865208365023136,
0.014656119048595428,
-0.04597296938300133,
0.0018215979216620326,
0.029077250510454178,
-0.005534586496651173,
-0.009409225545823574,
-0.00889178179204464,
0.005207593087106943,
0.002691803500056267,
0.0031380339059978724,
-0.012433655560016632,
-0.004026264883577824,
0.021782588213682175,
0.0030459293629974127,
-0.0051900167018175125,
0.006904426030814648,
-0.00468435138463974,
0.005515662021934986,
0.018623247742652893,
0.006905222311615944,
0.0026787882670760155,
0.015986915677785873,
-0.014246955513954163,
-0.01883099414408207,
0.014894303865730762,
0.0017527721356600523,
-0.012456756085157394,
0.0037423251196742058,
-0.019911155104637146,
-0.015516689047217369,
0.0030690887942910194,
0.007819121703505516,
0.009858639910817146,
0.0004868265241384506,
0.016865789890289307,
0.0205142330378294,
0.021970216184854507,
-0.019519200548529625,
0.0006381089333444834,
0.032174013555049896,
0.016905834898352623,
-0.006625589914619923,
0.012615948915481567,
-0.010549932718276978,
-0.07508991658687592,
-0.012037904001772404,
-0.010929541662335396,
-0.0014039844973012805,
0.010646647773683071,
0.0139324264600873,
-0.011157701723277569,
0.002177491318434477,
0.0013151122257113457,
-0.0027447605971246958,
-0.023963971063494682,
0.0061725713312625885,
-0.010436836630105972,
0.01743023470044136,
0.01202981173992157,
0.019868990406394005,
-0.010214378125965595,
-0.015924129635095596,
-0.022670699283480644,
0.006239518988877535,
-0.019716743379831314,
0.042258791625499725,
-0.001901174196973443,
-0.00008388404967263341,
0.00206178892403841,
-0.08124924451112747,
0.008660666644573212,
0.007863692939281464,
0.0030326861888170242,
0.0000980302575044334,
-0.009348606690764427,
0.01566811092197895,
-0.014624256640672684,
-0.03340689837932587,
-0.015915025025606155,
0.0059792762622237206,
0.001606228295713663,
-0.019967209547758102,
-0.02630581706762314,
0.00557186221703887,
-0.014230020344257355,
-0.006612760946154594,
0.024195335805416107,
0.00038972380571067333,
-0.007592417765408754,
0.00861962977796793,
0.024632692337036133,
-0.009318132884800434,
-0.010227641090750694,
-0.0021403231658041477,
-0.02091144025325775,
0.030117850750684738,
0.0027333099860697985,
0.012013710103929043,
0.0031358525156974792,
-0.014782889746129513,
0.014355518855154514,
-0.007610864005982876,
-0.002033922355622053,
-0.006851115729659796,
-0.011945327743887901,
0.00711232703179121,
-0.0016059388872236013,
0.02210039272904396,
0.005253630690276623,
-0.008497703820466995,
0.03986401483416557,
0.00435282289981842,
-0.00941539742052555,
0.0039052204228937626,
0.010125436820089817,
0.004539090674370527,
-0.008888784795999527,
0.01792692206799984,
-0.01317594014108181,
0.00586059782654047,
-0.008450688794255257,
-0.017789410427212715,
0.0034145989920943975,
-0.03399456664919853,
-0.007264908403158188,
-0.007034807465970516,
-0.0005642881151288748,
0.009305303916335106,
0.017566315829753876,
-0.003964721225202084,
0.01868065446615219,
0.0016357735730707645,
0.07103029638528824,
-0.01700032874941826,
0.01079921331256628,
-0.00988386943936348,
-0.006633944343775511,
0.0054048337042331696,
-0.020688757300376892,
-0.02251593768596649,
-0.012906031683087349,
-0.0071891797706484795,
0.013025172054767609,
-0.022915620356798172,
0.009854160249233246,
0.009842226281762123,
0.020132705569267273,
-0.0002723091747611761,
-0.02498805522918701,
-0.004790628328919411,
-0.025508278980851173,
0.0028826941270381212,
0.009229693561792374,
0.00275852857157588,
-0.013098923489451408,
0.01871534064412117,
0.012966372072696686,
-0.019530031830072403,
-0.02715841494500637,
-0.005789630115032196,
-0.021765217185020447,
0.025101814419031143,
-0.00045529298949986696,
0.009754620492458344,
0.00048661744222044945,
-0.008722257800400257,
0.014726999215781689,
0.005152353551238775,
-0.02516733668744564,
0.006906202994287014,
-0.015884647145867348,
0.014633560553193092,
-0.026268426328897476,
0.0035511692985892296,
-0.011426028795540333,
-0.010241970419883728,
0.009031678549945354,
-0.022107388824224472,
-0.009593252092599869,
0.028514914214611053,
0.00032756663858890533,
0.01015121303498745,
-0.02409045584499836,
-0.0033454936929047108,
0.016849199309945107,
0.016039075329899788,
-0.007099060341715813,
0.02024240978062153,
-0.005678074434399605,
0.007030991837382317,
-0.007088164798915386,
0.011397572234272957,
0.023432917892932892,
-0.013811890967190266,
0.008252844214439392,
-0.02395857684314251,
0.0130808986723423,
0.000059118494391441345,
0.011560268700122833,
-0.01919277012348175,
0.02164286933839321,
0.013076556846499443,
0.012993188574910164,
-0.025166388601064682,
0.0101618068292737,
-0.024841701611876488,
0.015868686139583588,
0.008876682259142399,
0.02162165567278862,
-0.008985992521047592,
0.01652820035815239,
0.0030360431410372257,
-0.01535772904753685,
-0.008365269750356674,
0.015790846198797226,
0.017568787559866905,
0.004773130640387535,
0.0019459044560790062,
0.024083677679300308,
0.009252484887838364,
-0.00581260584294796,
0.007802613079547882,
0.02024734765291214,
0.006163636222481728,
0.0027049705386161804,
0.009899922646582127,
0.011239178478717804,
0.03535453975200653,
0.029494570568203926,
0.0001585840800544247,
-0.0007145450217649341,
0.0016987252747640014,
-0.009494993835687637,
-0.00648875767365098,
-0.02370436117053032,
0.004172352608293295,
-0.03219199553132057,
-0.004567468538880348,
0.02790607511997223,
0.007687507197260857,
0.024173831567168236,
0.005599658004939556,
-0.011645834892988205,
-0.0038069772999733686,
0.006046442314982414,
-0.006172690074890852,
-0.006044004578143358,
-0.005394010804593563,
-0.007508253678679466,
0.0033563405741006136,
-0.0048680659383535385,
-0.010874093510210514,
0.012950247153639793,
-0.004776054061949253,
-0.005790856201201677,
0.02855735644698143,
0.01697002351284027,
0.0033404154237359762,
-0.0058571104891598225,
0.012387116439640522,
-0.009772605262696743,
-0.004679350182414055,
0.03072160854935646,
-0.0070047699846327305,
-0.013434430584311485,
0.004596547689288855,
-0.0011669062077999115,
0.004812545143067837,
0.02179405651986599,
0.018777266144752502,
-0.021366721019148827,
0.013822018168866634,
0.035251062363386154,
-0.02403019368648529,
0.0009318088414147496,
-0.010615591891109943,
0.006879245862364769,
-0.0010156556963920593,
0.006985966116189957,
-0.0056997304782271385,
0.009938543662428856,
-0.03417229279875755,
0.014193861745297909,
-0.0029606870375573635,
-0.010050012730062008,
-0.009051245637238026,
0.020259477198123932,
0.012044597417116165,
0.01473205629736185,
-0.011833866126835346,
0.009011096321046352,
-0.0009851446375250816,
-0.005064160563051701,
-0.00920724868774414,
-0.01072995737195015,
-0.01229686290025711,
0.01568586565554142,
-0.001575632020831108,
0.018625827506184578,
0.013875909149646759,
0.0031777052208781242,
-0.006495208013802767,
0.02008809708058834,
-0.0025200871750712395,
0.010639255866408348,
0.01713724620640278,
-0.03058232180774212,
-0.0012148087844252586,
-0.005295628681778908,
-0.02539917454123497,
-0.0012217527255415916,
-0.01440093107521534,
0.0014812024310231209,
0.017398260533809662,
0.008539962582290173,
-0.008425233885645866,
-0.002499943831935525,
-0.015202866867184639,
-0.012614834122359753,
-0.0064274901524186134,
0.008518406189978123,
-0.04450245574116707,
0.0022075315937399864,
-0.015217609703540802,
-0.006666409783065319,
0.022279534488916397,
0.01803024485707283,
-0.007943449541926384,
0.03043966367840767,
-0.0047930097207427025,
0.01323285698890686,
0.004258054308593273,
0.01294688694179058,
-0.028644023463129997
] | [
0.7077752947807312,
0.276391863822937,
-0.5065282583236694,
0.04025011509656906,
0.2801993787288666,
0.11157110333442688,
0.14908228814601898,
0.5623656511306763,
-0.2904868423938751,
-0.5919143557548523,
0.311037540435791,
-0.17232602834701538,
-0.2333061844110489,
0.7555360198020935,
-0.0156796183437109,
0.6683788299560547,
0.4793907403945923,
0.42796140909194946,
-0.2284792959690094,
-0.21796226501464844,
-0.40093645453453064,
-0.3536805212497711,
0.4740253984928131,
0.29091668128967285,
0.08045675605535507,
0.13194972276687622,
0.33966588973999023,
0.36924809217453003,
0.08752874284982681,
-0.16076146066188812,
-0.14228391647338867,
0.28125378489494324,
0.21405532956123352,
-0.1527896225452423,
0.09988512843847275,
-0.3001510500907898,
-0.17168855667114258,
0.056129857897758484,
0.0399174839258194,
-0.3044671416282654,
-0.2700423002243042,
-0.02617819607257843,
0.15730057656764984,
0.6463832259178162,
-0.2550443708896637,
-0.46063026785850525,
-1.1903715133666992,
1.0555100440979004,
-0.19301657378673553,
-0.1769869476556778,
0.6643453240394592,
0.13521815836429596,
-0.09559115767478943,
0.21139338612556458,
0.11877601593732834,
0.2126644253730774,
-0.3889848291873932,
0.15359631180763245,
0.08149514347314835,
-0.8577134609222412,
0.02800266444683075,
0.07928150147199631,
-0.31770190596580505,
0.15724091231822968,
-0.1345737725496292,
0.5143819451332092,
0.04100976511836052,
0.004327984061092138,
-0.12233389914035797,
-0.19068047404289246,
-0.023995881900191307,
-0.24906228482723236,
-0.44034117460250854,
0.1952943354845047,
-0.16569308936595917,
-0.05758250504732132,
-0.10595503449440002,
-0.18050776422023773,
0.6243508458137512,
0.042568083852529526,
-0.010378520004451275,
-0.45765823125839233,
0.06513629108667374,
-0.1744271218776703,
0.39816033840179443,
0.2818743586540222,
0.14189739525318146,
0.5532965064048767,
-0.2414725124835968,
-0.34427928924560547,
-0.2299913465976715,
-0.1898503452539444,
0.4490116834640503,
0.47266340255737305,
-0.11662638932466507,
0.19366604089736938,
0.7073614597320557,
-0.271795392036438,
0.2182864546775818,
-0.012378442101180553,
-0.6273946166038513,
-0.5074965953826904,
0.0926525741815567,
0.13221393525600433,
-0.15274199843406677,
0.029255561530590057,
-0.34477508068084717,
0.11159546673297882,
-0.49216973781585693,
0.2562893033027649,
-0.12766750156879425,
-0.10628437995910645,
-0.36719810962677,
-0.35224243998527527,
-0.09513410180807114,
-0.013989769853651524,
0.27552005648612976,
-0.7660590410232544,
0.20555312931537628,
-0.027430418878793716,
-0.108304962515831,
0.6338586211204529,
-0.5011429190635681,
0.2035696655511856,
-0.09919654577970505,
0.041618894785642624,
0.2940702736377716,
0.033440396189689636,
0.1285543590784073,
0.5269557237625122,
0.3877808749675751,
0.5116351246833801,
-0.3428492844104767,
-0.12368126213550568,
0.09970715641975403,
-0.24513910710811615,
-0.16629210114479065,
0.4211277961730957,
0.13006410002708435,
-0.2939067482948303,
-0.4295526146888733,
-0.5668128728866577,
-0.19578690826892853,
0.04747907444834709,
0.1455056071281433,
-0.48000773787498474,
-0.2841145396232605,
-0.10176890343427658,
0.3646131455898285,
-0.33219262957572937,
0.23509684205055237,
-0.10310084372758865,
-0.6607300639152527,
0.003299088915809989,
0.06938007473945618,
0.19142313301563263,
0.2421087920665741,
-0.5560906529426575,
-0.07244518399238586,
0.3385809063911438,
0.5861663222312927,
0.050617143511772156,
-0.02889883518218994,
-0.37458571791648865,
0.39539429545402527,
-0.0717470571398735,
0.39645135402679443,
0.4167798161506653,
-0.48079729080200195,
-0.1048661544919014,
-0.8609306216239929,
-0.2777324914932251,
0.09212090820074081,
-0.9803969264030457,
0.014742392115294933,
0.26151135563850403,
0.06542142480611801,
-0.1370886266231537,
0.3792639970779419,
0.17470493912696838,
-0.5181965231895447,
0.010620088316500187,
-0.34801483154296875,
-0.5520312190055847,
0.3539906144142151,
-0.3709585964679718,
0.38180091977119446,
-0.08217647671699524,
0.319709450006485,
-0.1073085144162178,
-0.44249221682548523,
-0.32086697220802307,
0.8605583310127258,
-0.39929744601249695,
1.3031758069992065,
-0.895080029964447,
-0.061190810054540634,
0.9225059747695923,
0.47280871868133545,
-0.3854927718639374,
-0.3500971496105194,
0.27788713574409485,
0.6020533442497253,
-0.3802544176578522,
-0.8591697216033936,
0.10473299026489258,
0.1445843130350113,
-0.40019312500953674,
0.1614374965429306,
-0.00828890223056078,
0.6494805216789246,
-0.41083526611328125,
0.055235981941223145,
-0.39158713817596436,
0.37626534700393677,
-0.3180857002735138,
-0.635148823261261,
0.041579265147447586,
-0.009900224395096302,
0.05697404220700264,
-0.1772080361843109,
-0.6591758728027344,
0.2921043634414673,
0.291363000869751,
-0.020270848646759987,
0.5554419159889221,
0.49622565507888794,
0.017178276553750038,
0.8263908624649048,
-0.7711434364318848,
0.3059481680393219,
-0.035198330879211426,
0.19326122105121613,
-0.7348056435585022,
-0.6025765538215637,
0.2841964364051819,
-0.17638374865055084,
0.22908754646778107,
-0.0002740722266025841,
0.12900690734386444,
-0.14963243901729584,
0.5587354302406311,
-0.8929914236068726,
-0.17327886819839478,
-0.33773189783096313,
-0.6079286932945251,
-0.6104927062988281,
0.01097820233553648,
-0.9878174662590027,
-0.04514843225479126,
0.14180848002433777,
0.5427507162094116,
0.024271581321954727,
-0.3496449291706085,
-0.032517965883016586,
0.07331928610801697,
0.18705110251903534,
-0.23801501095294952,
0.21503810584545135,
-0.4541679620742798,
-0.3393738269805908,
0.06429430097341537,
0.15286530554294586,
0.3478075861930847,
0.040741950273513794,
-0.12204483896493912,
-0.7553387880325317,
-0.44060802459716797,
0.8929735422134399,
0.6343239545822144,
1.0221415758132935,
-0.18202506005764008,
-0.4380359947681427,
0.1583617776632309,
0.42818909883499146,
-0.598101019859314,
0.2667207717895508,
1.2897276878356934,
-0.5039470791816711,
-0.26374420523643494,
-0.5831180810928345,
0.35245394706726074,
0.387878954410553,
-0.4686639606952667,
-0.08197855949401855,
-0.22995887696743011,
-0.10887004435062408,
-0.22387823462486267,
-0.24980191886425018,
0.17813554406166077,
-0.3277791738510132,
0.23184968531131744,
-0.09434672445058823,
-0.1246502622961998,
0.42068782448768616,
-0.04334566369652748,
-0.24875213205814362,
-0.04449640214443207,
0.49432554841041565,
-0.37016561627388,
0.04823291674256325,
0.3144574463367462,
-0.03350125625729561,
-0.07604043185710907,
0.11068525165319443,
0.2019941210746765,
-0.23453401029109955,
0.3051757514476776,
-5.968283653259277,
0.038950178772211075,
0.17351721227169037,
-0.3528997004032135,
-0.026762638241052628,
-0.1842651218175888,
1.0233948230743408,
0.490396112203598,
0.03984542936086655,
-0.07851944118738174,
0.6848196387290955,
0.4791915714740753,
0.06708289682865143,
-0.034495268017053604,
-0.19110359251499176,
0.06864086538553238,
0.3645719289779663,
-0.4264528155326843,
0.2774140536785126,
0.5600268840789795,
0.12508930265903473,
-0.08273925632238388,
-0.02475634589791298,
0.4408462643623352,
0.407537043094635,
0.2943263053894043,
-1.2454453706741333,
0.5677388906478882,
-0.24338290095329285,
-0.055842168629169464,
0.4970492422580719,
-0.8357334733009338,
0.204158216714859,
-0.24736692011356354,
0.1690567582845688,
-0.24362985789775848,
-0.3008043169975281,
-0.1512540578842163,
-0.2531350553035736,
0.09748748689889908,
-0.13898597657680511,
0.35411256551742554,
-0.34564638137817383,
-0.08843464404344559,
0.547788143157959,
-0.17858374118804932,
-0.12144775688648224,
0.4456116855144501,
-0.2787678837776184,
0.8805777430534363,
0.26252293586730957,
0.04097661375999451,
0.14350132644176483,
0.41170957684516907,
0.25114697217941284,
-0.12819986045360565,
-0.1625177562236786,
0.10787156969308853,
-0.4315631687641144,
0.1140955314040184,
0.009949786588549614,
-0.020646436139941216,
0.3696535527706146,
-0.012361818924546242,
0.2837684154510498,
-0.018573468551039696,
-0.6667134761810303,
-0.44520702958106995,
-0.0778074786067009,
-0.31975284218788147,
-0.24131330847740173,
0.10148801654577255,
0.04449052736163139,
-0.8887913823127747,
-0.09129442274570465,
-0.3481895923614502,
-0.11038820445537567,
0.02231699600815773,
0.4089420437812805,
-0.6603946089744568,
-0.11263441294431686,
-0.10593920201063156,
0.31660374999046326,
-0.25333094596862793,
0.02538388967514038,
0.17572185397148132,
-0.32189807295799255,
0.10031687468290329,
-0.40893298387527466,
0.3813675045967102,
0.6333023309707642,
-0.34095335006713867,
0.40503209829330444,
0.17339888215065002,
0.24326324462890625,
0.9350945353507996,
0.4807552099227905,
0.2173791080713272,
0.41878610849380493,
0.4090094566345215,
0.765180230140686,
-0.2554979622364044,
-0.46444201469421387,
-0.832722008228302,
0.07595869898796082,
-0.3547300100326538,
-0.02756570652127266,
0.23530614376068115,
0.7034798860549927,
-1.0625189542770386,
0.07003086060285568,
0.41892021894454956,
-0.05786306783556938,
-0.3401792049407959,
0.6140064597129822,
-0.5138868093490601,
0.20889407396316528,
-0.04509294405579567,
1.0181872844696045,
-0.29087844491004944,
0.5065823197364807,
0.8637074828147888,
-0.5516202449798584,
0.4813702404499054,
0.6266981363296509,
-0.1792987436056137,
0.1947959065437317,
0.34070494771003723,
-0.4496762156486511,
-0.28720054030418396,
-0.015105368569493294,
0.7688172459602356,
-0.11837641149759293,
0.03746761754155159,
0.3781152069568634,
-0.16155780851840973,
-0.3584814667701721,
0.02648300491273403,
0.37729451060295105,
-0.0693986788392067,
0.023192647844552994,
0.15135955810546875,
-0.23824968934059143,
-0.04083032160997391,
0.4153515100479126,
0.18106545507907867,
-0.19085894525051117,
0.4240056872367859,
0.17395412921905518,
-0.2161978930234909,
0.1814495325088501,
0.4363750219345093,
0.42141783237457275,
0.03806427866220474,
-0.7524651885032654,
0.10624305158853531,
0.643507719039917,
0.15098491311073303,
0.014221739955246449,
-0.5278154015541077,
0.44278016686439514,
0.00945882499217987,
-1.2631182670593262,
-0.15859879553318024,
-0.16859593987464905,
-0.39995136857032776,
0.6213663220405579,
-0.8003038763999939,
-0.1025165393948555,
0.25361987948417664,
-0.060879793018102646,
0.017069047316908836,
-0.3204771876335144,
0.15256717801094055,
-0.21662721037864685,
-0.2955280840396881,
-0.5559073686599731,
-0.0929742231965065,
-0.1473074108362198,
0.013425366021692753,
0.2802410423755646,
-0.12070541828870773,
-0.4932737946510315,
0.4482348561286926,
0.5212690234184265,
0.6036347150802612,
0.08269686996936798,
-0.15388123691082,
-0.2274719476699829,
-0.3469216525554657,
0.060617756098508835,
-0.25890982151031494,
0.355164110660553,
-0.06811518967151642,
0.04423101618885994,
0.1582617610692978,
0.12622494995594025,
0.19453613460063934,
0.017893273383378983,
-0.21377481520175934,
-0.14144232869148254,
0.6568638682365417,
-0.49352535605430603,
0.25165942311286926,
0.49285954236984253,
-0.2860538065433502,
0.2087341845035553,
-0.17558132112026215,
-0.01805374212563038,
-0.22886669635772705,
0.011630404740571976,
-0.0444767028093338,
-0.19409500062465668,
0.4628341495990753,
-0.42496007680892944,
-0.0692041888833046,
0.39111965894699097,
-0.4186306297779083,
-0.022885283455252647,
0.30522421002388,
0.37011823058128357,
0.30456414818763733,
0.045339662581682205,
-0.05681830272078514,
-0.18971464037895203,
0.5989157557487488,
0.9687073826789856,
-0.32208722829818726,
-0.08652015775442123,
0.13122256100177765,
-0.7613881826400757,
0.10253558307886124,
0.08050379902124405,
-0.21990421414375305,
-0.729661226272583,
-0.08810988068580627,
0.36246609687805176,
0.02013215236365795,
0.015757422894239426,
0.31270918250083923,
0.05067131668329239,
0.5077294707298279,
-0.1413397341966629,
-0.43785858154296875,
0.053275831043720245,
0.33320412039756775,
0.2697698771953583,
-0.47872379422187805,
-0.09093325585126877,
0.06469572335481644,
0.08820696920156479,
-0.26346710324287415,
-0.19826291501522064,
0.22137947380542755,
0.17699100077152252,
-0.28958338499069214,
-0.2182789444923401,
-0.2580588459968567,
-0.06260059773921967,
0.17214474081993103,
-0.23862092196941376,
-0.24322551488876343,
0.15739178657531738,
0.07290523499250412,
-0.07221084088087082,
-0.16147607564926147,
-0.3425740897655487,
-0.055863723158836365,
0.1520177721977234,
-0.3647277355194092,
0.0710642859339714,
-0.09140540659427643,
0.6853973865509033,
0.42271775007247925,
-0.17136381566524506,
0.290889173746109,
-0.682895839214325,
-0.047565899789333344,
-0.3109301030635834,
0.40756332874298096,
-0.46831217408180237,
-0.6045069098472595,
0.24296899139881134,
-0.48954761028289795,
0.6137189865112305,
-0.6548046469688416,
0.09540756046772003,
0.011782641522586346,
0.07505090534687042,
-0.4922528564929962,
-0.46652817726135254,
-0.1549910306930542,
-0.26419344544410706,
-0.4711417555809021,
0.12083138525485992,
0.009241553023457527,
0.08394333720207214,
0.6266580820083618,
0.7437848448753357,
-0.026971500366926193,
-0.5233544707298279,
0.46660116314888,
0.3203125298023224,
-0.17023062705993652,
0.2197263538837433,
-0.049135394394397736,
-0.11682997643947601,
0.026251252740621567,
-0.39275965094566345,
0.1860312819480896,
0.4709402620792389,
-0.2947302758693695,
-0.08934583514928818,
0.06594312191009521,
-0.16146880388259888,
0.1769365817308426,
-0.4058831036090851,
-0.5298911333084106,
0.36625877022743225,
0.08135661482810974,
-0.09126012027263641,
0.6547860503196716,
0.6070613861083984,
-0.19742685556411743,
0.1399335116147995,
0.3246625065803528,
-0.04457569122314453,
0.5702800154685974,
0.018780961632728577,
0.12052067369222641,
0.37345370650291443,
0.4271814823150635,
-0.22178538143634796,
0.35643577575683594,
-0.02053093910217285,
0.4544711709022522,
0.5017919540405273,
-0.84320467710495,
-0.17943446338176727,
-0.5166711807250977,
0.7435283660888672,
-0.16192980110645294,
-0.15709681808948517,
-0.6471364498138428,
0.07254794985055923,
0.3001928925514221,
-0.3412342667579651,
0.022633591666817665,
-0.22065439820289612,
0.4647357761859894,
0.07047564536333084,
-0.5786758065223694,
-0.6960448026657104,
-0.10059573501348495,
0.01183427032083273,
0.33389148116111755,
0.15035182237625122,
-0.42631757259368896,
-0.8003206849098206,
0.1702621579170227,
-0.13313747942447662,
-0.03665183112025261,
0.09998295456171036,
0.5524979829788208,
-0.176376610994339,
0.29531130194664,
0.14146116375923157,
-0.13778477907180786,
0.4009700119495392,
-0.17756007611751556,
-0.3457455337047577,
-0.44585996866226196,
-0.02720669098198414,
0.26250019669532776,
0.6234613060951233,
-0.4319833219051361,
0.005114326719194651,
0.14970985054969788,
-0.10877803713083267,
0.5704706907272339,
-0.37131208181381226,
-0.13028329610824585,
-0.4225463271141052,
-0.13814613223075867,
-0.180572509765625,
-0.30725863575935364,
-0.2919444143772125,
-0.12000727653503418,
-0.16609463095664978,
-0.03734802454710007,
0.1231948509812355,
-0.44656437635421753,
-0.11297621577978134,
0.17496982216835022,
-0.01184077002108097,
-0.26309850811958313,
0.05068696662783623,
0.27488160133361816,
-0.2524503767490387,
0.37350234389305115,
0.008072025142610073,
0.00010983345418935642,
0.018504871055483818,
0.4270574748516083,
-0.3057957589626312,
0.2460571527481079,
-0.30596861243247986,
-0.08692824095487595,
-0.5954110026359558,
0.042722489684820175,
0.6196940541267395,
0.07586100697517395,
-0.5874003171920776,
0.13896961510181427,
0.06133522838354111,
-0.008001616224646568,
0.2578304708003998,
-0.1268649399280548,
-0.20015168190002441,
-0.5472326874732971,
-0.20317226648330688,
-0.7102616429328918,
0.5727879405021667,
-0.029724668711423874,
-0.29637888073921204,
-0.16810615360736847,
0.29866495728492737,
0.5163915157318115,
-0.3243955373764038,
0.5151629447937012,
-0.7215023040771484,
0.1212325468659401,
-0.6955705881118774,
0.38993576169013977,
-0.38119977712631226,
0.11593236029148102,
0.6315646767616272,
0.30823028087615967,
-0.33264121413230896,
-0.3306327760219574,
0.2158684879541397,
-0.10782074183225632,
0.22429287433624268,
-0.08103055506944656,
0.1944928765296936,
0.61520916223526,
0.1329520344734192,
-0.19151198863983154,
-0.3793365955352783,
0.40511104464530945,
-0.031914494931697845,
-0.49539151787757874,
-0.10584908723831177,
0.12088412791490555,
-0.1837443858385086,
-0.03363700211048126,
0.0940360501408577,
-0.4488104283809662,
0.2828670144081116,
-0.20283547043800354
] |
Mammalian sperm become fertile after completing capacitation, a process associated with cholesterol loss and changes in the biophysical properties of the sperm membranes that prepares the sperm to undergo the acrosome reaction. Different laboratories have hypothesized that cholesterol efflux can influence the extent and/or movement of lipid raft microdomains. In a previous study, our laboratory investigated the identity of sperm proteins putatively associated with rafts. After extraction with Triton X-100 and ultracentrifugation in sucrose gradients, proteins distributing to the light buoyant-density fractions were cored from polyacrylamide gels and microsequenced. In this study, a subset of these proteins (TEX101, basigin, hexokinase 1, facilitated glucose transporter 3, IZUMO, and SPAM1) and other molecules known to be enriched in membrane rafts (caveolin 2, flotillin 1, flotillin 2, and the ganglioside GM3) were selected to investigate their localization in the sperm and their behavior during capacitation and the acrosome reaction. These molecules localize to multiple sperm domains, including the acrosomal cap (IZUMO, caveolin 2, and flotillin 2), equatorial segment (GM3), cytoplasmic droplet (TEX101), midpiece (basigin, facilitated glucose transporter 3, and flotillin 2), and principal piece (facilitated glucose transporter 3). Some of these markers modified their immunofluorescence pattern after sperm incubation under capacitating conditions, and these changes correlated with the occurrence of the acrosome reaction. While GM3 and caveolin 2 were not detected after the acrosome reaction, flotillin 2 was found in the equatorial segment of acrosome-reacted sperm, and IZUMO distributed along the sperm head, reaching the post- and para-acrosomal areas. Taking into consideration the requirement of the acrosome reaction for sperm to become fusogenic, these results suggest that membrane raft dynamics may have a role in sperm-egg membrane interaction. | [
0.0006700594676658511,
0.01695842668414116,
-0.00027851443155668676,
0.030922243371605873,
0.008700509555637836,
-0.022318297997117043,
0.011080751195549965,
0.00017083017155528069,
-0.018234288319945335,
-0.0029967171140015125,
-0.0034058564342558384,
0.01613125577569008,
-0.009596196003258228,
0.03223013877868652,
-0.0243714340031147,
-0.019086362794041634,
-0.0026703081093728542,
0.00739474780857563,
0.012811354361474514,
0.020180020481348038,
-0.00030296389013528824,
-0.01719282753765583,
0.011221503838896751,
-0.028645675629377365,
-0.021181397140026093,
-0.03192611038684845,
0.0295663233846426,
-0.0021438368130475283,
0.022432681173086166,
0.02917705476284027,
0.02151578851044178,
0.00005498575046658516,
-0.010173819027841091,
0.011027421802282333,
0.010925846174359322,
0.01056601945310831,
-0.005208010785281658,
0.025494005531072617,
0.03644469380378723,
-0.004532892256975174,
-0.0080180112272501,
-0.011476689018309116,
0.0148577019572258,
0.009886608459055424,
-0.011840388178825378,
-0.023831872269511223,
0.005234586074948311,
0.006688345223665237,
-0.03158383071422577,
0.0018642890499904752,
-0.016126517206430435,
-0.00534109678119421,
-0.0028102651704102755,
0.04658278077840805,
-0.007169422693550587,
-0.023313723504543304,
0.020187679678201675,
-0.009254339151084423,
-0.015069495886564255,
0.012260820716619492,
-0.004894347861409187,
0.0241670161485672,
-0.02872457355260849,
0.0016655062790960073,
0.00805679801851511,
-0.06692499667406082,
0.026460936293005943,
0.011842979118227959,
0.00446128286421299,
0.03718124330043793,
-0.005981271155178547,
0.007429882884025574,
0.027359964326024055,
0.02226720005273819,
0.0016698273830115795,
-0.022310076281428337,
-0.0026623844169080257,
0.02191215567290783,
0.010912411846220493,
0.011781470850110054,
-0.015650222077965736,
-0.008770796470344067,
0.001653402578085661,
-0.0032858417835086584,
0.004432890564203262,
0.0071358829736709595,
-0.005780127830803394,
0.006301288027316332,
-0.002560565248131752,
-0.026997528970241547,
0.005976798012852669,
-0.017383374273777008,
-0.015071280300617218,
0.003494711359962821,
-0.017485633492469788,
-0.028769101947546005,
0.017469372600317,
-0.04436046630144119,
-0.0028188200667500496,
0.01431098859757185,
-0.02028822898864746,
0.008230650797486305,
0.02509916201233864,
-0.011771906167268753,
0.028266936540603638,
0.009399077855050564,
0.013503191992640495,
-0.006562995724380016,
0.03471772000193596,
0.011547119356691837,
0.0019524905364960432,
0.007507089991122484,
-0.0015973142581060529,
-0.009750524535775185,
-0.011033719405531883,
0.03529856353998184,
-0.0029379851184785366,
0.05171089246869087,
0.015949038788676262,
0.00683271698653698,
-0.015299823135137558,
-0.00795384868979454,
0.00262462068349123,
0.029251333326101303,
0.0023016384802758694,
-0.011980818584561348,
-0.002793333027511835,
0.02712932974100113,
0.00027401442639529705,
-0.0019242700655013323,
-0.008539249189198017,
-0.0048576463013887405,
0.01179598644375801,
-0.015486310236155987,
0.005681796930730343,
0.003378144931048155,
0.016555335372686386,
-0.04429331421852112,
-0.0036081073340028524,
-0.012467794120311737,
-0.013957090675830841,
0.008336280472576618,
-0.0026054587215185165,
0.01734057068824768,
0.01761024445295334,
-0.008028153330087662,
-0.003550818655639887,
0.011363920755684376,
-0.008531719446182251,
-0.009689395315945148,
0.01730828359723091,
0.0022991630248725414,
0.0018047420307993889,
-0.01687687262892723,
-0.0025453129783272743,
0.0035519544035196304,
0.002226694254204631,
-0.01133137010037899,
0.012979592196643353,
0.011567199602723122,
0.009636114351451397,
0.005925656761974096,
0.01837105304002762,
0.01008398924022913,
-0.020679593086242676,
0.016058601438999176,
-0.0017073624767363071,
-0.017897196114063263,
0.006249676458537579,
0.00801202841103077,
0.0020626424811780453,
0.020753534510731697,
-0.007525116205215454,
0.0033426478039473295,
0.01030512060970068,
-0.002796655986458063,
-0.011688800528645515,
0.008087662979960442,
-0.02165566198527813,
0.06655371189117432,
0.030468255281448364,
0.04862307757139206,
0.001145925372838974,
0.020330315455794334,
0.003134172409772873,
-0.005403372459113598,
0.03660215437412262,
-0.010891880840063095,
0.030066199600696564,
-0.015833057463169098,
-0.0217709019780159,
-0.04080638289451599,
0.02216378040611744,
0.010420545935630798,
0.020759906619787216,
0.0023144013248384,
-0.0015806355513632298,
-0.004733706824481487,
-0.0003397772088646889,
-0.0399845652282238,
0.012673793360590935,
-0.00009820377454161644,
0.009298578836023808,
-0.006978986319154501,
-0.028365425765514374,
-0.0071100108325481415,
-0.03352469950914383,
-0.0021306665148586035,
-0.006105367094278336,
-0.0012362946290522814,
0.01583011820912361,
-0.008135131560266018,
0.002218865090981126,
-0.013633821159601212,
-0.0027056385297328234,
-0.0003632502630352974,
0.0006067198701202869,
-0.0016629997408017516,
-0.008742655627429485,
-0.012226941995322704,
0.0011731750564649701,
0.023805830627679825,
0.007838496938347816,
-0.02461506426334381,
0.008927161805331707,
0.011550835333764553,
-0.012508219107985497,
0.013926532119512558,
-0.006119268015027046,
-0.009685039520263672,
0.006919939070940018,
-0.012840889394283295,
-0.013173110783100128,
0.024793222546577454,
-0.0059323618188500404,
-0.02808666229248047,
0.014240220189094543,
-0.002541857771575451,
0.020136063918471336,
-0.013115130364894867,
-0.013466272503137589,
-0.026187144219875336,
-0.003491828218102455,
-0.025338852778077126,
-0.01951594464480877,
0.015953296795487404,
0.027820732444524765,
0.0042138597927987576,
-0.023537179455161095,
-0.016481729224324226,
0.009325994178652763,
-0.009236215613782406,
-0.03992391377687454,
-0.01373573113232851,
0.028670016676187515,
-0.011202337220311165,
0.01755600795149803,
0.00564961601048708,
0.023380612954497337,
0.0022877550218254328,
0.015626754611730576,
0.008482755161821842,
-0.030392516404390335,
-0.015462306328117847,
-0.004970018286257982,
0.006596586667001247,
0.00866321474313736,
0.008079496212303638,
0.0008269211975857615,
0.032197073101997375,
0.01070362702012062,
-0.005029007792472839,
-0.010472370311617851,
-0.08084620535373688,
-0.016658268868923187,
-0.008050096221268177,
-0.01884579285979271,
0.008527563884854317,
0.010586190037429333,
0.0008422327227890491,
-0.011197534389793873,
-0.015507996082305908,
-0.002054472453892231,
0.012501861900091171,
-0.007750922814011574,
-0.0023486546706408262,
0.007339068688452244,
0.0064217811450362206,
-0.006730881053954363,
0.010288054123520851,
0.016273874789476395,
-0.023011354729533195,
-0.01676950976252556,
0.012522390112280846,
0.0026859515346586704,
-0.00019756704568862915,
0.008694642223417759,
-0.012203323654830456,
0.01086490973830223,
-0.0037170208524912596,
-0.005539833102375269,
-0.004265898838639259,
0.018244870007038116,
-0.01131892018020153,
-0.019422344863414764,
0.00765073299407959,
0.006393522024154663,
0.010084651410579681,
0.01358739659190178,
-0.017322421073913574,
-0.0107247494161129,
-0.020332643762230873,
0.01006543729454279,
-0.002014756668359041,
0.022195633500814438,
-0.004811372607946396,
0.0009606392704881728,
0.006908448878675699,
0.012389837764203548,
-0.0037806802429258823,
-0.008388143964111805,
0.018882643431425095,
-0.00823158584535122,
-0.011092839762568474,
0.0059065306559205055,
0.012159348465502262,
0.01949303224682808,
-0.011427117511630058,
0.019977092742919922,
-0.009152711369097233,
0.02447802945971489,
-0.008333370089530945,
-0.01652413234114647,
0.00019233301281929016,
-0.01317822840064764,
-0.003373280167579651,
0.05682716891169548,
0.002541031688451767,
0.0025003377813845873,
0.02003488689661026,
0.015918783843517303,
-0.01294485293328762,
0.016732849180698395,
0.015431568026542664,
0.014656826853752136,
-0.00739515433087945,
-0.004056624602526426,
-0.030722588300704956,
-0.019110936671495438,
-0.011914879083633423,
0.0077083478681743145,
-0.005507772322744131,
-0.007766113616526127,
-0.004332573618739843,
0.00950612686574459,
0.003172628115862608,
0.02464061602950096,
-0.023358751088380814,
-0.02981402352452278,
0.006774800829589367,
0.030345486477017403,
0.004939132370054722,
-0.01255942601710558,
0.023363512009382248,
-0.004263344686478376,
0.033727049827575684,
0.005311192944645882,
0.018614185974001884,
-0.00773056223988533,
-0.00035281642340123653,
-0.008198795840144157,
-0.021493464708328247,
0.009918143972754478,
-0.042562853544950485,
0.0007914169691503048,
-0.01761329360306263,
-0.01264911238104105,
-0.03158608451485634,
0.012160828337073326,
0.01796826720237732,
-0.020345881581306458,
0.004642339888960123,
-0.008482115343213081,
0.0088343545794487,
-0.027544397860765457,
-0.0037782671861350536,
0.02995111420750618,
0.007393281906843185,
0.024801617488265038,
-0.0195084847509861,
0.00996650755405426,
0.07203472405672073,
-0.013958205468952656,
0.0064339530654251575,
-0.016770020127296448,
0.00997300073504448,
-0.06181923300027847,
0.00960359163582325,
-0.004859088454395533,
0.02181500941514969,
-0.005717024207115173,
0.012259680777788162,
-0.019588861614465714,
0.007016621530056,
-0.0005620012525469065,
-0.04307138919830322,
-0.0006282732356339693,
-0.014062941074371338,
-0.027008110657334328,
0.0008158395066857338,
0.006017444655299187,
-0.02974831685423851,
-0.019299466162919998,
-0.009608723223209381,
-0.010777238756418228,
0.030783379450440407,
-0.0003490578383207321,
-0.004335467703640461,
-0.013418307527899742,
-0.02450830489397049,
0.008539177477359772,
0.007068857084959745,
-0.01407075859606266,
-0.004200852010399103,
0.03253073990345001,
0.03256302326917648,
-0.0074520837515592575,
0.01899041421711445,
0.004681224003434181,
0.0036766466218978167,
0.00779864564538002,
-0.0059865182265639305,
-0.01777390018105507,
-0.022529441863298416,
0.015403907746076584,
0.011073721572756767,
-0.00946065317839384,
0.009033361449837685,
-0.003879210911691189,
0.0012876468244940042,
0.002659816527739167,
-0.0013207971351221204,
0.005472926422953606,
0.008496858179569244,
0.028374332934617996,
0.0030665546655654907,
0.03256506845355034,
-0.0036233128048479557,
-0.004354638978838921,
0.008647887967526913,
0.011125771328806877,
-0.018718142062425613,
-0.03467376530170441,
0.01939578726887703,
-0.02051679976284504,
-0.0008752564899623394,
-0.01388536486774683,
-0.021785371005535126,
0.012762474827468395,
0.0009754770435392857,
0.004157697781920433,
0.026593981310725212,
-0.02030588872730732,
-0.0016378728905692697,
-0.019883131608366966,
-0.01862337812781334,
-0.03768109157681465,
-0.01201602816581726,
-0.002542569302022457,
-0.005128565710037947,
-0.01687021553516388,
-0.02350499853491783,
-0.0008833042811602354,
-0.010815070942044258,
-0.003976763691753149,
-0.0007682451978325844,
-0.027975549921393394,
-0.016599182039499283,
-0.07427453994750977,
0.011404379270970821,
-0.005930270068347454,
-0.010126426815986633,
0.010271454229950905,
-0.0031168744899332523,
-0.023495422676205635,
0.01145937293767929,
0.0003630078863352537,
-0.007828720845282078,
-0.04314402490854263,
-0.01909586228430271,
0.015238286927342415,
-0.019963793456554413,
0.012196270748972893,
-0.0018338133813813329,
-0.007056132890284061,
0.017540521919727325,
-0.05251248553395271,
-0.008533259853720665,
0.021667296066880226,
-0.004445233847945929,
-0.04294969141483307,
0.014127068221569061,
-0.002170770661905408,
-0.08067934960126877,
-0.007899099960923195,
0.0010813651606440544,
-0.006884793750941753,
-0.0033577349968254566,
-0.023058786988258362,
-0.00273419008590281,
-0.011309290304780006,
0.007340967655181885,
-0.019200600683689117,
-0.021488159894943237,
-0.007548242807388306,
0.02497042343020439,
-0.0169904176145792,
-0.0017246163915842772,
-0.007287364453077316,
0.014529543928802013,
-0.014849185012280941,
0.00026132469065487385,
-0.0026157977990806103,
-0.003040292067453265,
0.010312131606042385,
-0.010535772889852524,
-0.010012616403400898,
-0.014914811588823795,
0.015484095551073551,
-0.0074714007787406445,
0.0021745036356151104,
0.027421465143561363,
-0.016762617975473404,
-0.008338544517755508,
0.008841434493660927,
-0.00485372357070446,
-0.013100933283567429,
-0.011687815189361572,
-0.01031558308750391,
-0.02559506520628929,
-0.014073525555431843,
-0.011170323006808758,
0.0006445718463510275,
-0.011914036236703396,
-0.0009381982963532209,
0.013563595712184906,
-0.015800021588802338,
0.005685893818736076,
-0.034942254424095154,
0.004498443566262722,
-0.013387976214289665,
0.02449297532439232,
-0.015815410763025284,
0.005444686859846115,
-0.009767944924533367,
0.0035024601966142654,
-0.0032621726859360933,
0.0017613545060157776,
0.0077467067167162895,
-0.004560665227472782,
0.003604928031563759,
-0.007217103615403175,
-0.002898982260376215,
-0.015794023871421814,
0.0014275885187089443,
0.012472627684473991,
0.07168656587600708,
-0.009385984390974045,
-0.015609480440616608,
-0.009425408206880093,
0.011043774895370007,
0.008852780796587467,
-0.025935392826795578,
-0.02078956365585327,
0.04188301041722298,
-0.019669601693749428,
0.032870903611183167,
-0.005411314778029919,
0.00192254688590765,
0.011057178489863873,
0.004475791938602924,
-0.002801993628963828,
0.020800992846488953,
-0.0007614318747073412,
0.019147995859384537,
0.030304493382573128,
-0.002862966153770685,
-0.0068131848238408566,
0.006640565115958452,
-0.003700570436194539,
-0.009757217951118946,
-0.006659994833171368,
-0.014916259795427322,
0.020490948110818863,
0.0013581803068518639,
0.016407756134867668,
-0.0021936162374913692,
-0.005071232095360756,
0.009063739329576492,
0.009212237782776356,
0.01496884599328041,
0.018534576520323753,
0.00437680259346962,
-0.00021650019334629178,
-0.012248015031218529,
0.014046686701476574,
0.0066397408954799175,
0.024079948663711548,
-0.012099691666662693,
-0.006402857135981321,
0.024015041068196297,
0.006442095153033733,
0.00419561518356204,
-0.017981287091970444,
0.007585826329886913,
0.008045058697462082,
0.025499669834971428,
0.0016789620276540518,
0.008198032155632973,
0.013603540137410164,
0.01302639115601778,
0.006635731551796198,
0.0060099046677351,
0.021765640005469322,
0.0033616824075579643,
-0.055898990482091904,
0.007977362722158432,
-0.012619106099009514,
0.01091891061514616,
-0.021946225315332413,
0.019125299528241158,
-0.020501945167779922,
0.014520563185214996,
-0.012452878057956696,
-0.026839056983590126,
0.012636985629796982,
0.0008025553543120623,
-0.009726069867610931,
0.007811823859810829,
-0.024681275710463524,
0.019505701959133148,
0.007076885551214218,
0.007200948894023895,
-0.009700442664325237,
-0.011851377785205841,
0.013087434694170952,
-0.016451358795166016,
0.012135645374655724,
-0.049015190452337265,
0.007554901763796806,
0.015840020030736923,
-0.005758766084909439,
-0.013712947256863117,
0.0007349229417741299,
-0.017262089997529984,
0.011735585518181324,
0.00437631132081151,
-0.011518828570842743,
0.003940613940358162,
0.01633272133767605,
0.010182957164943218,
0.033425021916627884,
0.0179289598017931,
0.0010891701094806194,
0.011813919991254807,
0.022352255880832672,
-0.023217033594846725,
-0.028306683525443077,
-0.010555760003626347,
0.006134846247732639,
-0.023053020238876343,
-0.016923028975725174,
-0.006767931394279003,
-0.007736912462860346,
-0.0002188938669860363,
0.01964706741273403,
0.012926524505019188,
-0.0071788993664085865,
0.02364613488316536,
0.004588693380355835,
0.018768731504678726,
0.01516355387866497,
0.00031869253143668175,
0.009064603596925735,
-0.005696872249245644,
-0.0073225912638008595,
-0.023847874253988266,
0.000928711611777544,
-0.0033553235698491335,
0.019603075459599495,
0.003546433988958597,
-0.0233110710978508,
-0.0097334124147892,
0.012045934796333313,
-0.0013264005538076162,
0.00469402689486742,
-0.0023417589254677296,
0.021326057612895966,
0.016347333788871765,
-0.010611826553940773,
-0.023248938843607903,
-0.0023517911322414875,
-0.0117129972204566,
-0.02779877558350563,
-0.0015888377092778683,
-0.015797343105077744,
-0.02174704149365425,
-0.014044506475329399,
0.00007751176599413157,
0.01403699442744255,
0.008192864246666431,
-0.007966218516230583,
0.024121563881635666,
0.02244916930794716,
0.01863105595111847,
0.019336137920618057,
-0.0008083959110081196,
0.01623278111219406,
0.02081361413002014,
-0.005880892742425203,
-0.00782223790884018,
0.015486122108995914,
0.012562111020088196,
0.028586655855178833,
-0.007977642118930817,
-0.027053654193878174,
0.02598336525261402,
0.0021564261987805367,
-0.02551094815135002,
0.004282389767467976,
0.024866053834557533,
0.05039031431078911,
0.0022001585457473993,
-0.006032324396073818,
0.0054682414047420025,
-0.0010958469938486814,
-0.010339618660509586,
-0.01013187225908041,
-0.019019978120923042,
0.008778570219874382,
0.009323222562670708,
-0.01652924343943596,
0.013148248195648193,
-0.011454576626420021,
-0.014284949749708176,
0.00101748900488019,
0.004998144693672657,
0.011583768762648106,
-0.005815529264509678,
-0.009038346819579601,
-0.002441476099193096,
-0.0033149458467960358,
0.0025032139383256435,
0.01483541913330555,
0.0028435627464205027,
0.006980191916227341,
0.0027940694708377123,
-0.008542055264115334,
-0.004888167604804039,
0.004787759855389595,
-0.016954051330685616,
0.010952526703476906,
0.0211031436920166,
-0.02551250159740448,
-0.011101080104708672,
-0.002237014938145876,
-0.008269986137747765,
-0.00151593959890306
] | [
0.06891090422868729,
-0.19554564356803894,
0.1614995151758194,
0.10144737362861633,
0.061935123056173325,
0.00457358593121171,
-0.12591415643692017,
0.0403788685798645,
-0.13786262273788452,
-0.49463650584220886,
0.059555888175964355,
0.23264352977275848,
-0.02734667807817459,
0.03136651590466499,
-0.22028812766075134,
0.5714900493621826,
0.4783906042575836,
0.418583482503891,
-0.07561014592647552,
-0.6209972500801086,
0.011592570692300797,
-0.004211498890072107,
0.298838347196579,
-0.06442192941904068,
0.6320602297782898,
-0.5019176602363586,
0.19095873832702637,
0.1970352977514267,
0.40984848141670227,
-0.19451339542865753,
-0.8477796316146851,
-0.012848051264882088,
-0.4408443868160248,
0.4785069227218628,
-0.15734994411468506,
-0.1840735375881195,
-0.24621285498142242,
-0.556318998336792,
0.17415161430835724,
-0.31326988339424133,
-0.35833805799484253,
-0.3211841583251953,
0.020401310175657272,
0.6015127897262573,
-0.4629881978034973,
-0.09036319702863693,
-0.6914337873458862,
0.6008414030075073,
0.05731932073831558,
0.2789151966571808,
-0.3427737355232239,
-0.23176613450050354,
-0.2541830539703369,
0.2091788351535797,
0.15262460708618164,
0.5806059241294861,
-0.20696961879730225,
0.502082884311676,
-0.10125749558210373,
-0.49028319120407104,
-0.10582425445318222,
-0.11159341782331467,
-0.2579275369644165,
0.5568499565124512,
0.4274389147758484,
0.3270983099937439,
0.6117673516273499,
-0.5837423205375671,
-0.1386968493461609,
-0.21678517758846283,
-0.5483560562133789,
-0.7070062756538391,
-0.3708924949169159,
0.37128955125808716,
-0.3704834282398224,
0.05907779932022095,
-0.5517679452896118,
0.08286809921264648,
0.3638368248939514,
0.2501744329929352,
-0.06332999467849731,
0.23963765799999237,
-0.12662310898303986,
0.6155654788017273,
0.049008700996637344,
0.3630968928337097,
0.0853201225399971,
0.47080060839653015,
-0.15580527484416962,
0.24511457979679108,
-0.05696212127804756,
-0.2677626609802246,
0.39530807733535767,
0.29806268215179443,
-0.03151366487145424,
-0.014597064815461636,
-0.03654887154698372,
0.061706576496362686,
0.5081343650817871,
-0.033189430832862854,
-0.34445053339004517,
-0.02439214289188385,
-0.11822489649057388,
-0.4078280031681061,
-0.5629197359085083,
-0.9189114570617676,
-0.47247788310050964,
-0.46082553267478943,
0.06549318134784698,
-0.11857911199331284,
0.33775290846824646,
0.06702550500631332,
0.21316055953502655,
0.5349718928337097,
0.2264813929796219,
0.4700552523136139,
-0.016550637781620026,
-0.4211358428001404,
-0.45954668521881104,
-0.2479253113269806,
-0.24990598857402802,
0.8695499300956726,
-0.026856154203414917,
-0.033857181668281555,
0.03466573357582092,
-0.12649106979370117,
0.6153144240379333,
0.40059471130371094,
-0.0974293053150177,
0.13565747439861298,
0.2622279226779938,
0.4778500199317932,
-0.22053000330924988,
0.5575863718986511,
-0.14443805813789368,
-0.10514335334300995,
-0.07128864526748657,
-0.381202757358551,
0.8011788129806519,
0.11404716223478317,
-0.963056743144989,
-0.2691231369972229,
0.23398344218730927,
-0.15200509130954742,
0.36054307222366333,
-0.11016156524419785,
0.002194279571995139,
-0.1573779433965683,
-0.5336892604827881,
-0.006183583289384842,
-0.16226014494895935,
-0.1461343765258789,
-0.10459538549184799,
-0.2970193922519684,
-0.03968125581741333,
0.2769462466239929,
0.39751604199409485,
0.020840898156166077,
-0.35021406412124634,
0.21033647656440735,
-0.2741127908229828,
0.20740874111652374,
-0.25419744849205017,
-0.3315618336200714,
-0.24552017450332642,
-0.2688363790512085,
1.0390520095825195,
0.44233858585357666,
0.0018204903462901711,
-0.0171787291765213,
0.1256874054670334,
-0.25499945878982544,
0.3860108554363251,
-0.0033473700750619173,
-0.3672139644622803,
-0.6109047532081604,
0.5622977018356323,
0.04871762916445732,
0.4753015637397766,
0.013723629526793957,
-0.5896491408348083,
0.43122100830078125,
-0.01138191856443882,
0.13590118288993835,
0.05857715755701065,
-0.18840059638023376,
-0.11346355825662613,
-0.06722584366798401,
-0.604230523109436,
-0.18312065303325653,
0.4304276704788208,
-0.24628491699695587,
0.23603886365890503,
-0.3562525808811188,
1.0942615270614624,
-0.2749479115009308,
-0.397546648979187,
0.36049091815948486,
-0.13631388545036316,
0.04211125895380974,
-0.4521891474723816,
0.5963515639305115,
0.21343231201171875,
-0.4520969092845917,
-0.6747069954872131,
0.2821909189224243,
0.3371255099773407,
-0.3711649775505066,
0.37919607758522034,
0.16617773473262787,
-0.06961759924888611,
0.339592844247818,
0.39345139265060425,
-0.6471266746520996,
0.2935364544391632,
0.06931933015584946,
-0.1458262950181961,
0.36000996828079224,
-0.12032219767570496,
-0.039076339453458786,
0.6530030369758606,
-0.019775599241256714,
0.6028538346290588,
0.29042133688926697,
0.11700283735990524,
0.7909237146377563,
0.35577496886253357,
-0.13445648550987244,
0.342292457818985,
0.19249024987220764,
0.21300837397575378,
-0.38080140948295593,
0.3576529622077942,
0.30079078674316406,
-0.43101561069488525,
-0.17849111557006836,
0.26837462186813354,
-0.42367833852767944,
0.15370143949985504,
0.11801432818174362,
0.20935435593128204,
0.8429787755012512,
-0.6113463044166565,
-0.07640445232391357,
-0.11057860404253006,
-0.36683616042137146,
0.26697278022766113,
0.02782697230577469,
-0.7674734592437744,
-0.8883447051048279,
-0.5576938390731812,
0.49700629711151123,
-0.10183136910200119,
0.13195942342281342,
0.13748958706855774,
-0.6507889628410339,
-0.4636715352535248,
-0.004538177978247404,
0.5375718474388123,
-0.3727554678916931,
0.04477308318018913,
-0.28939253091812134,
0.2494715005159378,
-0.19009003043174744,
-0.08241858333349228,
-0.1956581175327301,
-0.39295580983161926,
-0.6219974756240845,
0.6585338711738586,
0.8437904715538025,
0.38476353883743286,
0.47718560695648193,
-0.8754100799560547,
0.031076705083251,
0.2249646633863449,
-0.2736669182777405,
0.24650397896766663,
0.007552155759185553,
-0.13886494934558868,
-0.1643303632736206,
0.23122070729732513,
0.18115557730197906,
0.29339563846588135,
-0.1396220326423645,
-0.8145667910575867,
-0.18632690608501434,
-0.2678845226764679,
-0.5739949345588684,
0.13328522443771362,
-0.6917873620986938,
-0.2837499976158142,
0.30892226099967957,
-0.24110212922096252,
-0.4303048253059387,
0.24046459794044495,
0.3644193708896637,
0.05278303846716881,
0.021982459351420403,
0.5193495154380798,
-0.11177928000688553,
-0.4096178710460663,
-0.22229957580566406,
-0.25060319900512695,
-0.15385177731513977,
0.19788400828838348,
0.04473729059100151,
0.34687289595603943,
0.00010134573676623404,
-6.039719104766846,
-0.24793531000614166,
-0.006526191718876362,
0.1310136318206787,
0.5762390494346619,
-0.16248010098934174,
0.6619114875793457,
-0.054747872054576874,
0.4954395592212677,
-0.24814710021018982,
0.19663342833518982,
0.15763480961322784,
-0.2041255384683609,
0.1412084996700287,
-0.254172682762146,
-0.20946288108825684,
0.5920172333717346,
0.13536058366298676,
0.4094710946083069,
-0.24096429347991943,
0.04887004941701889,
-0.17079660296440125,
-0.10378090292215347,
0.6218920946121216,
0.11957871168851852,
0.22642141580581665,
-0.44487711787223816,
0.05109826847910881,
-0.028265275061130524,
0.027276797220110893,
-0.5689851641654968,
-0.5161943435668945,
0.19360849261283875,
-0.1456666886806488,
0.674322783946991,
0.5156400799751282,
0.47323399782180786,
0.005718337371945381,
0.4189155101776123,
0.18913476169109344,
0.5233545899391174,
0.5059577822685242,
-0.23452533781528473,
-0.21390974521636963,
0.19983620941638947,
-0.2874808609485626,
-0.16098183393478394,
0.2822335660457611,
0.28705528378486633,
0.4760029911994934,
-0.04365132749080658,
0.09257277846336365,
0.008851427584886551,
-0.3311917185783386,
0.4745676815509796,
0.5045292973518372,
0.22843478620052338,
0.20727716386318207,
0.008980536833405495,
-0.38618138432502747,
-0.13174425065517426,
-0.4683070778846741,
-0.05235537514090538,
-0.4081908166408539,
-0.10225851088762283,
0.3612499237060547,
-0.45183032751083374,
-0.038725726306438446,
0.30145353078842163,
0.1031612977385521,
-0.788852334022522,
0.25617969036102295,
0.14461784064769745,
-0.6518423557281494,
0.6958954334259033,
-0.708819568157196,
-0.228098526597023,
0.19347582757472992,
-0.3992238938808441,
-0.2256668210029602,
-0.46527618169784546,
-0.1551387459039688,
-0.2718118727207184,
0.2187635600566864,
0.05495290458202362,
-0.9766300916671753,
-0.25468799471855164,
-0.04028122499585152,
0.15969258546829224,
-0.3980710506439209,
0.5491560697555542,
-0.5850486755371094,
0.21928654611110687,
0.3342802822589874,
0.357770711183548,
0.35508105158805847,
-0.2021530121564865,
0.2236221730709076,
0.43476155400276184,
-0.07132872939109802,
0.5331476330757141,
0.14989863336086273,
-0.6341524720191956,
-0.6976158022880554,
-0.6238884925842285,
0.0869426429271698,
-0.36818450689315796,
0.16640634834766388,
0.6606942415237427,
-0.37531617283821106,
0.09236147254705429,
0.10733744502067566,
-0.53480464220047,
-0.5425159931182861,
0.37104642391204834,
-0.05304625630378723,
-0.009932269342243671,
0.5803241729736328,
0.7879408001899719,
0.04391602426767349,
0.23587282001972198,
-0.06536722928285599,
-0.8416970372200012,
-0.4934534430503845,
0.49723875522613525,
-0.16977842152118683,
0.3473730981349945,
0.21289308369159698,
-0.23654884099960327,
-0.4076952338218689,
0.4398244321346283,
0.21277794241905212,
-0.04686791077256203,
0.028454720973968506,
0.19611072540283203,
0.2835173010826111,
-0.07967004925012589,
-0.4292214810848236,
-0.1483343243598938,
-0.3743981122970581,
-0.06538860499858856,
-0.05777163803577423,
-0.002124735154211521,
-0.46428748965263367,
0.2772377133369446,
0.10629042237997055,
0.0005528563051484525,
-0.08119193464517593,
-0.23460644483566284,
0.11825685948133469,
0.1758076250553131,
-0.11113506555557251,
0.3427148163318634,
-0.0799407809972763,
-0.08674474060535431,
-0.3754262328147888,
0.6993923783302307,
0.28745266795158386,
-0.14507274329662323,
-0.29747486114501953,
-0.10843460261821747,
-0.17859533429145813,
-0.4450371265411377,
-0.03741616755723953,
-0.07877323031425476,
-0.06859634071588516,
-0.272860586643219,
-0.2035871297121048,
0.04650910943746567,
0.3319622278213501,
-0.07489165663719177,
-0.04606256261467934,
0.08591226488351822,
-0.24880126118659973,
-0.24298860132694244,
-0.4520617425441742,
0.042303089052438736,
0.033263593912124634,
-0.12722313404083252,
0.010579073801636696,
0.18442587554454803,
-0.4764486253261566,
0.08572820574045181,
0.0002976194955408573,
0.20924484729766846,
-0.28390878438949585,
0.2392750382423401,
-0.12192073464393616,
-0.6403091549873352,
0.026834284886717796,
-0.3158028721809387,
0.3470597267150879,
0.8549723029136658,
-0.3781731128692627,
-0.06871625781059265,
0.45369255542755127,
-0.16809003055095673,
0.912086546421051,
-0.25220048427581787,
-0.32229599356651306,
0.582840085029602,
-0.3908047676086426,
-0.9903825521469116,
0.09252431243658066,
0.34704557061195374,
0.18549107015132904,
-0.16971759498119354,
-0.04803134873509407,
0.3734176754951477,
0.020002953708171844,
-0.17716121673583984,
-0.5183176398277283,
0.1848219931125641,
0.5979260206222534,
0.08786558359861374,
0.04030429199337959,
0.046654071658849716,
-0.1126924604177475,
0.14091327786445618,
0.287637859582901,
0.19635029137134552,
0.19002951681613922,
-0.5515124201774597,
0.009815624915063381,
0.06106876581907272,
-0.052168697118759155,
0.45295125246047974,
-0.3550366759300232,
0.014937971718609333,
-0.20806865394115448,
0.5156007409095764,
-0.4809202253818512,
-0.5125243663787842,
-0.11980000138282776,
0.1818416565656662,
-0.09435685724020004,
0.31306785345077515,
0.004653509706258774,
-0.13100513815879822,
0.3027995824813843,
0.5833244919776917,
0.5995320677757263,
-0.31120535731315613,
0.5178483128547668,
-0.3396172821521759,
0.33284690976142883,
0.09464725852012634,
-0.5417251586914062,
-0.3889108896255493,
0.3742188811302185,
0.4590657353401184,
-0.44178667664527893,
0.06129512935876846,
0.15708115696907043,
0.13859964907169342,
0.05963914096355438,
0.1958114355802536,
-0.0970875695347786,
-0.28402695059776306,
0.5241549611091614,
-0.008346648886799812,
-0.12085391581058502,
-0.8526004552841187,
-0.18939295411109924,
0.22272296249866486,
-0.2656576931476593,
-0.7204956412315369,
0.12146984040737152,
0.2446773499250412,
0.47054553031921387,
0.1317683905363083,
0.018666064366698265,
0.26164931058883667,
-0.1110774502158165,
0.021443508565425873,
0.014782858081161976,
-0.2621254622936249,
0.24002116918563843,
0.04704229533672333,
0.2664335370063782,
-0.20367175340652466,
-0.09639932215213776,
0.6329759359359741,
-0.5131815671920776,
-0.048046648502349854,
-0.6166291832923889,
0.05464155972003937,
-0.5544096231460571,
-0.2624067962169647,
0.31045010685920715,
-0.05233270302414894,
-0.16877369582653046,
-0.6695072054862976,
-0.554959237575531,
0.40436309576034546,
0.4629831612110138,
0.2963040769100189,
0.0718856081366539,
-0.33079153299331665,
0.5415411591529846,
-0.5770664811134338,
0.8477910161018372,
0.32459256052970886,
-0.8078818321228027,
0.25706639885902405,
0.06376548856496811,
-0.049924515187740326,
0.20404461026191711,
-0.3683745563030243,
-0.18015512824058533,
0.21707488596439362,
0.1274765282869339,
0.2850356996059418,
0.2832055985927582,
-0.5349442362785339,
0.2061387449502945,
0.2679998278617859,
-0.23416155576705933,
-0.2151498794555664,
0.40166136622428894,
0.47080883383750916,
0.13116277754306793,
-0.2155015766620636,
-0.2918003797531128,
-0.20778867602348328,
-0.18835903704166412,
0.2718179523944855,
0.21394270658493042,
0.20973214507102966,
0.2266852706670761,
0.6952571868896484,
-0.06149831414222717,
-0.10477400571107864,
-0.09231235831975937,
0.13523083925247192,
0.4316483438014984,
-0.30622363090515137,
-0.590374767780304,
-0.6315265893936157,
0.816703200340271,
1.1385300159454346,
0.12533541023731232,
-0.4434129595756531,
-0.25644850730895996,
-0.019099369645118713,
0.1448989063501358,
0.01275077648460865,
-0.29207009077072144,
0.20440645515918732,
0.5529303550720215,
0.495526522397995,
-0.7708706855773926,
-0.12146636098623276,
0.3437866270542145,
-0.5412211418151855,
-0.6407226920127869,
0.4005003273487091,
-0.4102681875228882,
-0.7732561826705933,
-0.2795793116092682,
-0.2922760248184204,
0.1529434472322464,
0.36853528022766113,
0.25934070348739624,
0.3347301185131073,
0.060398511588573456,
0.4832135736942291,
-0.016304323449730873,
0.7816460132598877,
-0.630409836769104,
0.15383699536323547,
0.5297998189926147,
-0.3257744610309601,
-0.5736002326011658,
0.34746408462524414,
0.16336509585380554,
0.2572799026966095,
-0.10501602292060852,
-0.00801081582903862,
0.31020545959472656,
-0.4879280924797058,
-0.28398481011390686,
-0.4296858608722687,
-0.35694578289985657,
-0.46147993206977844,
-0.00660938024520874,
0.2679104208946228,
-0.10214182734489441,
0.051558274775743484,
0.14008675515651703,
0.12204678356647491,
-0.18242980539798737,
0.6013454794883728,
0.5171709656715393,
-0.6097850799560547,
-0.3328361511230469,
0.44351959228515625,
0.23415684700012207,
0.27774807810783386,
0.6140921115875244,
0.3399829566478729,
0.7182724475860596,
-0.22854766249656677,
0.13127660751342773,
-0.3013663589954376,
0.37759822607040405,
-0.714603841304779,
0.08379301428794861,
-0.37939056754112244,
-0.40741634368896484,
1.0479804277420044,
-0.08366448432207108,
-0.06847550719976425,
0.10276190936565399,
0.2683805823326111,
0.38652098178863525,
0.3160899877548218,
-0.4058261215686798,
0.29233455657958984,
-0.40003857016563416,
-0.11040598899126053,
-0.46574392914772034,
-0.12545427680015564,
0.6885636448860168,
0.13794255256652832,
0.1054035872220993,
0.5784125328063965,
-0.03263144940137863,
-0.8777784705162048,
0.07987993955612183,
-0.8140296339988708,
0.5590891242027283,
-0.5272727012634277,
0.15555064380168915,
-0.10101688653230667,
-0.431383341550827,
0.08860133588314056,
-0.08722716569900513,
0.28242072463035583,
-0.6265212297439575,
0.48657989501953125,
0.2780735194683075,
0.10243149846792221,
0.5317519903182983,
-0.265423983335495,
-0.5517547726631165,
0.2039472758769989,
-0.5955812931060791,
-0.8412797451019287,
-0.1020512655377388,
-0.0830799862742424,
-0.33222800493240356,
0.3409770429134369,
0.09244793653488159,
-0.3665508031845093,
-0.426445871591568,
0.4314284920692444,
-0.16344912350177765,
0.21206282079219818,
0.3273581862449646
] |
Since the inception of global gene expression profiling platforms in the mid-1990s, there has been a significant increase in publications of differentially expressed genes in the process of epileptogenesis. In particular for mesial temporal lobe epilepsy, the presence of a latency period between the first manifestation of seizures to chronic epilepsy provides the opportunity for therapeutic interventions at the molecular biology level. Using global expression profiling techniques, approximately 2000 genes have been published demonstrating differential expression in mesial temporal epilepsy. The majority of these changes, however, are specific to laboratory or experimental conditions with only 53 genes demonstrating changes in more than two publications. To this end, we review the current status of gene expression profiling in epileptogenesis and suggest standard guidelines to be followed for greater accuracy and reproducibility of results. | [
-0.0011317101307213306,
0.0033764331601560116,
-0.025705505162477493,
0.010288668796420097,
0.017949016764760017,
0.002407992957159877,
0.011441100388765335,
0.0002663623308762908,
-0.016930459067225456,
-0.0024081398732960224,
0.012482516467571259,
0.020958036184310913,
-0.0046437871642410755,
0.0076452563516795635,
0.0008114390075206757,
0.018656693398952484,
-0.027432281523942947,
0.01353942509740591,
0.015230643562972546,
0.014878729358315468,
0.04020702838897705,
-0.005784440785646439,
0.011273998767137527,
-0.02825944311916828,
0.021145492792129517,
0.005178138613700867,
0.00277300039306283,
-0.01284453272819519,
0.0041163912974298,
-0.009599458426237106,
0.01053860504180193,
-0.0018322714604437351,
0.0028558638878166676,
0.019440654665231705,
0.0008428152650594711,
0.00745640741661191,
0.003691908437758684,
0.02267075702548027,
0.0165907833725214,
-0.005246997345238924,
-0.01629529520869255,
-0.017968181520700455,
0.004009215161204338,
-0.007897406816482544,
-0.0065555451437830925,
-0.021727561950683594,
-0.008268939331173897,
0.0021142081823199987,
-0.0034283590503036976,
0.012473338283598423,
-0.018494494259357452,
-0.03206006437540054,
-0.012665760703384876,
-0.0076010641641914845,
-0.006940403487533331,
-0.0012991963885724545,
0.021152283996343613,
-0.0038075330667197704,
-0.01594330370426178,
0.030224936082959175,
-0.0010138838551938534,
0.017079461365938187,
0.04953640326857567,
-0.014162762090563774,
-0.024321168661117554,
-0.06675031036138535,
0.01165806595236063,
0.024583980441093445,
0.003580360906198621,
-0.02180522307753563,
0.0060051204636693,
0.016795171424746513,
-0.007897085510194302,
0.00197529885917902,
0.043365273624658585,
0.017080256715416908,
-0.007134345360100269,
0.03578345477581024,
0.014944976195693016,
-0.015031423419713974,
-0.016652226448059082,
-0.03198449686169624,
-0.012549582868814468,
0.027202097699046135,
-0.017514223232865334,
0.011103466153144836,
-0.006834988482296467,
0.018153076991438866,
0.0019292783690616488,
-0.0006465248297899961,
0.007610491942614317,
-0.021730788052082062,
-0.027161337435245514,
0.009049857035279274,
-0.03897056356072426,
0.00454662786796689,
-0.0078224316239357,
-0.028929390013217926,
0.0010521970689296722,
-0.013555148616433144,
-0.014487366192042828,
0.01880192756652832,
0.02398223988711834,
0.03403850644826889,
-0.00649333605542779,
0.01192858349531889,
0.013256223872303963,
0.03095802292227745,
0.008445054292678833,
0.008384105749428272,
-0.011076977476477623,
0.019306130707263947,
0.0029982777778059244,
0.005041738040745258,
0.004156202077865601,
-0.01110344473272562,
0.0011145565658807755,
0.03504495322704315,
0.007943419739603996,
0.02231983095407486,
0.015013373456895351,
0.017242763191461563,
0.00229327823035419,
0.007299256511032581,
0.00007578189251944423,
-0.007289363071322441,
-0.030975479632616043,
0.012028862722218037,
0.021117139607667923,
0.004693310707807541,
-0.007340616546571255,
0.0023398003540933132,
0.02135462313890457,
0.009451006539165974,
0.008861085399985313,
-0.0002510458289179951,
-0.03749120980501175,
-0.018138473853468895,
-0.0016888491809368134,
-0.0024969857186079025,
-0.0016458651516586542,
0.008794899098575115,
0.0043949526734650135,
0.019004611298441887,
0.023301901295781136,
0.007517877034842968,
0.041470739990472794,
-0.01246272586286068,
-0.011201627552509308,
-0.0257007647305727,
0.0056387316435575485,
-0.014926586300134659,
-0.0013526980765163898,
-0.023240383714437485,
0.013831259682774544,
0.02251291275024414,
-0.02081533707678318,
-0.015096142888069153,
0.005010559223592281,
0.020791681483387947,
0.005977746564894915,
0.019183266907930374,
0.015389764681458473,
0.009281753562390804,
-0.007678142748773098,
-0.018593795597553253,
-0.010352177545428276,
0.0019023360218852758,
-0.02057269960641861,
0.004663014784455299,
0.0011820817599073052,
0.0003627107944339514,
0.0022710952907800674,
0.01037324033677578,
-0.020634528249502182,
-0.005564084742218256,
0.03650651127099991,
0.008073437958955765,
-0.012598485685884953,
0.06735695898532867,
-0.01993861049413681,
-0.01907425746321678,
-0.012223219498991966,
0.030968977138400078,
-0.0005811112932860851,
0.004036158323287964,
0.019990496337413788,
-0.011536292731761932,
0.0007216795347630978,
0.013541256077587605,
-0.012288444675505161,
0.01680438220500946,
0.013174398802220821,
-0.01614220440387726,
-0.02438172698020935,
0.0038807704113423824,
0.004435253329575062,
-0.01843053475022316,
-0.00571353267878294,
0.00902392528951168,
0.022707581520080566,
-0.02522895112633705,
0.02193938009440899,
0.0027736788615584373,
0.02760917693376541,
0.028770770877599716,
0.00810544565320015,
-0.026445673778653145,
0.003515226300805807,
0.011504294350743294,
0.009431537240743637,
-0.008475350216031075,
-0.0002987863263115287,
-0.00046198046766221523,
-0.01745898649096489,
-0.005216616205871105,
0.009316792711615562,
-0.02012770250439644,
-0.0013725224416702986,
-0.017735276371240616,
0.0019456963054835796,
-0.0014546358725056052,
0.013847757130861282,
0.0021782899275422096,
0.03936947509646416,
-0.018235353752970695,
-0.002406046027317643,
0.010764067992568016,
-0.020444698631763458,
0.006932529620826244,
-0.019782401621341705,
-0.004121448844671249,
-0.01096588745713234,
0.06557951867580414,
-0.0005028806626796722,
0.004259229172021151,
0.014377017505466938,
0.015114189125597477,
0.016152506694197655,
-0.012659907341003418,
-0.024427348747849464,
0.0005804371321573853,
0.0017467583529651165,
-0.0058767301961779594,
0.01182249840348959,
0.01820872351527214,
0.004649136681109667,
0.010378804057836533,
-0.003646603086963296,
-0.011733867228031158,
0.007701575290411711,
-0.00026445998810231686,
0.0171499066054821,
-0.01631803996860981,
0.01726190187036991,
-0.009430844336748123,
0.004970093723386526,
-0.02108907885849476,
0.02431897260248661,
-0.005842260550707579,
-0.0020858440548181534,
0.00786085706204176,
-0.01733398251235485,
0.00143373291939497,
-0.02970902994275093,
0.053055912256240845,
0.019905343651771545,
0.0025368654169142246,
0.030247889459133148,
-0.0066133467480540276,
0.005035196430981159,
-0.005858131684362888,
-0.0061036585830152035,
-0.08103662729263306,
-0.006810072809457779,
0.0156976580619812,
-0.010453412309288979,
0.009406205266714096,
0.00617474690079689,
0.01630730740725994,
0.014351265504956245,
0.004638859536498785,
-0.01719043403863907,
0.038202933967113495,
-0.018324393779039383,
-0.00539365503937006,
-0.003930449951440096,
0.0064689042046666145,
-0.006340347230434418,
0.017266936600208282,
0.013807926326990128,
0.002949768677353859,
-0.015495935454964638,
-0.005423841066658497,
-0.0017513297498226166,
0.029004083946347237,
0.0015388547908514738,
-0.02021057903766632,
0.009211365133523941,
0.005146372597664595,
0.0038395042065531015,
-0.01691792532801628,
-0.0011478416854515672,
-0.006889257580041885,
-0.005637314636260271,
0.013899406418204308,
0.010409535840153694,
0.011926831677556038,
0.009287404827773571,
0.007307699881494045,
0.007171012461185455,
-0.00545485271140933,
0.025088075548410416,
0.009789934381842613,
0.014695904217660427,
-0.01958591863512993,
-0.014834295026957989,
0.006569803226739168,
-0.0011821442749351263,
0.00010599661618471146,
-0.009831055998802185,
0.025547094643115997,
0.007097895257174969,
0.014589853584766388,
0.006505751051008701,
0.023668471723794937,
0.010887417942285538,
-0.02566993609070778,
-0.01887323148548603,
-0.02402288094162941,
-0.008223089389503002,
-0.007588396780192852,
-0.009296703152358532,
0.013304011896252632,
0.009493782185018063,
-0.015153495594859123,
0.0005008280277252197,
0.0020884883124381304,
-0.007696113549172878,
0.013298720121383667,
-0.009507644921541214,
0.014446426182985306,
0.01566636934876442,
-0.009427104145288467,
-0.018366971984505653,
-0.006819522473961115,
0.0019714918453246355,
-0.008966270834207535,
-0.013147072866559029,
-0.012888058088719845,
-0.01843041181564331,
0.02068467251956463,
-0.03288113698363304,
-0.007441802881658077,
0.0025526226963847876,
0.017098302021622658,
-0.0005845678970217705,
-0.02392135001718998,
-0.022768136113882065,
0.010194100439548492,
0.023321442306041718,
0.02454211190342903,
-0.014032860286533833,
-0.0000412424560636282,
0.02751888893544674,
0.02269657328724861,
0.010805591009557247,
-0.003826257074251771,
-0.001024290919303894,
-0.021721195429563522,
-0.003779887454584241,
0.0029746501240879297,
0.011755586601793766,
0.01912214420735836,
-0.015359137207269669,
0.009175430983304977,
-0.011390872299671173,
0.00109391612932086,
0.010557429865002632,
0.008856100961565971,
0.0029532297048717737,
0.001296425936743617,
-0.0050952620804309845,
-0.01504868920892477,
-0.015376513823866844,
-0.008062324486672878,
0.0002538135740906,
0.016096826642751694,
0.002948155626654625,
0.01369496900588274,
-0.020203933119773865,
0.0717475563287735,
0.015123853459954262,
0.009988714009523392,
-0.027032149955630302,
0.020168866962194443,
-0.021541882306337357,
-0.02828538976609707,
-0.000325147295370698,
0.010578974150121212,
-0.006137777119874954,
0.012677119113504887,
0.01268685981631279,
-0.010710217989981174,
0.016210192814469337,
-0.028647666797041893,
-0.005186319816857576,
-0.003369951155036688,
0.005379761569201946,
0.015182378701865673,
-0.0013159001246094704,
0.030991163104772568,
-0.03244224935770035,
-0.01244434155523777,
-0.004878106061369181,
-0.027314763516187668,
-0.03392484039068222,
-0.006144320126622915,
-0.017204761505126953,
-0.014728844165802002,
0.0063743614591658115,
0.02933216094970703,
-0.014310010708868504,
-0.00731535442173481,
0.016651704907417297,
0.00038364995270967484,
0.013896606862545013,
0.029651226475834846,
0.020616400986909866,
-0.004320967011153698,
-0.0034095034934580326,
0.01931079849600792,
-0.014788464643061161,
-0.009831337258219719,
0.01684996485710144,
0.03225420415401459,
0.007331385742872953,
0.019486315548419952,
-0.003621994284912944,
-0.007122351322323084,
0.006877843290567398,
-0.022507455199956894,
0.019443843513727188,
0.017253223806619644,
0.025441329926252365,
0.008237614296376705,
-0.005058846436440945,
0.037434171885252,
-0.007097749039530754,
0.020652061328291893,
0.013746654614806175,
-0.03412104398012161,
-0.029739495366811752,
-0.004494811408221722,
-0.016164837405085564,
0.007185518741607666,
-0.028014563024044037,
-0.01095802802592516,
-0.0004028412513434887,
-0.01476393174380064,
0.009205950424075127,
0.004968270659446716,
0.020437821745872498,
-0.03198673576116562,
-0.005760409869253635,
-0.020747844129800797,
0.0017454095650464296,
-0.00009121838957071304,
-0.008728613145649433,
-0.007477435749024153,
0.002534027211368084,
0.00211379025131464,
0.015809277072548866,
0.004842174239456654,
-0.026077883318066597,
0.008636713959276676,
0.005762131884694099,
-0.009738750755786896,
-0.0741318017244339,
0.00669694971293211,
0.02124512381851673,
-0.0106160007417202,
0.027365699410438538,
0.007583640515804291,
-0.01891172118484974,
0.004677323158830404,
0.028034768998622894,
-0.00014696200378239155,
0.04044916480779648,
-0.021171879023313522,
-0.007141944952309132,
-0.011657649651169777,
0.013563413172960281,
0.04648471623659134,
-0.014574021100997925,
0.010800921358168125,
0.008369570598006248,
0.0017914922209456563,
0.011726323515176773,
-0.006211940664798021,
-0.0177077017724514,
0.006103824824094772,
-0.014956898987293243,
-0.08065210282802582,
0.0004838407039642334,
-0.0040188925340771675,
0.014414150267839432,
-0.010763072408735752,
0.008400047197937965,
0.008631715551018715,
-0.015765605494379997,
-0.006080739200115204,
-0.017097366973757744,
0.01677842065691948,
0.009299181401729584,
0.007017022464424372,
-0.0025414503179490566,
0.0024369116872549057,
-0.0007241949206218123,
0.013355551287531853,
-0.0038538442458957434,
-0.023258673027157784,
0.00025696679949760437,
-0.014088399708271027,
-0.016842076554894447,
-0.005846020765602589,
-0.01220938004553318,
-0.00974930077791214,
-0.011465800926089287,
-0.02437639981508255,
0.015531145967543125,
0.017837848514318466,
-0.00021765287965536118,
-0.010501284152269363,
-0.014129692688584328,
-0.01793067529797554,
0.005792018957436085,
-0.013275513425469398,
-0.016196735203266144,
-0.01962578296661377,
-0.016113897785544395,
0.01743997633457184,
0.01083349995315075,
0.0007713616359978914,
0.004792055115103722,
-0.025163203477859497,
-0.0010919441701844335,
-0.009237325750291348,
-0.00829676166176796,
0.007947300560772419,
-0.009000102989375591,
-0.0024038772098720074,
-0.0026683476753532887,
0.002146979793906212,
-0.006219306495040655,
0.02365613728761673,
0.023836515843868256,
0.015045695938169956,
0.02134137973189354,
-0.0036411897744983435,
0.017380954697728157,
0.026256542652845383,
0.006302963010966778,
-0.005790470167994499,
0.007705759257078171,
0.010079591535031796,
0.07209271192550659,
-0.013712476007640362,
0.027459116652607918,
-0.027687322348356247,
-0.00030891550704836845,
-0.00495649129152298,
-0.024402137845754623,
-0.012586244381964207,
-0.017513159662485123,
0.010585996322333813,
0.006366741843521595,
0.00561048137024045,
0.034647032618522644,
0.010839884169399738,
0.003603781573474407,
-0.0002230326645076275,
0.019794821739196777,
0.018223995342850685,
0.015596654266119003,
0.001976880943402648,
-0.01682887226343155,
0.006261314265429974,
-0.0338168740272522,
0.02874547615647316,
0.012078125961124897,
-0.0015658363699913025,
-0.0029491856694221497,
0.0015962161123752594,
-0.01057280134409666,
0.019369836896657944,
-0.022095544263720512,
-0.002559137064963579,
-0.0033244099467992783,
-0.005387429613620043,
0.029398810118436813,
0.004165886901319027,
-0.009018033742904663,
0.01043867040425539,
0.0010869649704545736,
0.023135848343372345,
-0.024744924157857895,
-0.013320589438080788,
0.01065671257674694,
0.012921416200697422,
0.021713998168706894,
-0.009314756840467453,
0.005220720078796148,
0.023236345499753952,
0.01808471977710724,
0.0019862866029143333,
0.018715541809797287,
-0.001059867674484849,
0.019418857991695404,
-0.0025420603342354298,
0.02440306916832924,
-0.0008360601495951414,
-0.0016452029813081026,
0.026087861508131027,
-0.004769723862409592,
-0.014191011898219585,
0.00757171493023634,
-0.012822141870856285,
-0.03872906044125557,
-0.01612083427608013,
-0.007773983292281628,
-0.019673047587275505,
0.004832434002310038,
-0.01143304631114006,
-0.01544747594743967,
0.017440665513277054,
-0.0029041387606412172,
-0.01615966111421585,
0.007131556980311871,
0.008990336209535599,
0.025729747489094734,
0.010594352148473263,
-0.022330204024910927,
0.018488533794879913,
0.009924713522195816,
0.013325524516403675,
-0.01287725567817688,
0.02066151611506939,
0.0003453632816672325,
0.009453898295760155,
-0.017351506277918816,
0.02247043140232563,
-0.02191072702407837,
0.007500876672565937,
-0.002844087081030011,
0.01230212114751339,
-0.0013194489292800426,
-0.004565451759845018,
0.0001216702803503722,
0.022913215681910515,
0.013177242130041122,
0.03444313257932663,
0.007206410635262728,
0.0013021016493439674,
0.008179917931556702,
-0.021755417808890343,
0.001575917936861515,
-0.012442570179700851,
-0.03359028697013855,
-0.03295884281396866,
-0.015496949665248394,
0.0027144502382725477,
0.004331896081566811,
-0.01926833763718605,
-0.003915576264262199,
0.02192167192697525,
-0.007343675009906292,
-0.03928366303443909,
0.034034792333841324,
-0.014227913692593575,
0.031873829662799835,
-0.019770445302128792,
-0.0007376088760793209,
-0.012528249993920326,
-0.00006340118125081062,
-0.009686879813671112,
-0.006408541463315487,
-0.0021887575276196003,
-0.009615364484488964,
0.02537020668387413,
0.019241906702518463,
-0.018897829577326775,
-0.00908676441758871,
0.03686787933111191,
-0.013028392568230629,
-0.023629600182175636,
0.018467023968696594,
-0.006386823020875454,
-0.017503712326288223,
-0.0013362118043005466,
0.024325424805283546,
0.0005963221192359924,
0.018795326352119446,
-0.0053815096616744995,
-0.014257051050662994,
-0.009028340689837933,
0.03690412640571594,
-0.0199656430631876,
0.0032956290524452925,
-0.015930112451314926,
0.01087732519954443,
-0.011849899776279926,
-0.0006318546365946531,
0.020612921565771103,
-0.0027488023042678833,
0.00740948598831892,
-0.005134955979883671,
0.011804223991930485,
0.017469115555286407,
-0.0033026491291821003,
0.026634573936462402,
0.023058410733938217,
0.01923670619726181,
-0.013569310307502747,
-0.01426718384027481,
0.015785258263349533,
0.001335672102868557,
0.020239174365997314,
-0.0038460425566881895,
0.0044175973162055016,
0.03410409390926361,
0.01983340084552765,
-0.003751251846551895,
0.0064468663185834885,
0.012028639204800129,
-0.0024050334468483925,
0.0013963193632662296,
0.007261798717081547,
-0.027062535285949707,
0.03493174910545349,
-0.027914077043533325,
-0.0016695254016667604,
-0.0007301911246031523,
0.004682283848524094,
0.0009187718387693167,
0.014784172177314758,
0.02176019735634327,
-0.016244150698184967,
-0.010335490107536316,
-0.015263184905052185,
-0.005830826237797737,
-0.00094962352886796,
-0.0073449271731078625,
-0.02554655261337757,
0.004163432866334915,
0.008149204775691032,
0.020359348505735397,
0.000620941398665309,
-0.018163379281759262,
-0.009619695134460926,
-0.0018226427491754293,
-0.029799282550811768,
0.02974996343255043,
-0.003850592765957117,
0.025091389194130898,
0.007631498388946056,
0.03122694045305252,
-0.009320641867816448
] | [
-0.14484864473342896,
0.018338384106755257,
-0.2194487303495407,
0.3424406945705414,
0.024896886199712753,
0.2392081320285797,
0.1809849739074707,
0.22584927082061768,
-0.08336010575294495,
-0.4921293258666992,
0.27174440026283264,
0.2739049792289734,
-0.5282120704650879,
0.5235554575920105,
-0.24908088147640228,
0.27658170461654663,
-0.14869549870491028,
-0.20002079010009766,
-0.2081422358751297,
-0.22277989983558655,
-0.02951175719499588,
-0.46644458174705505,
0.333313912153244,
-0.06355470418930054,
-0.33227723836898804,
0.04290473088622093,
0.38937103748321533,
-0.06372290849685669,
-0.27076518535614014,
0.4514066278934479,
-0.2718827724456787,
0.9473251700401306,
0.19979608058929443,
-0.02311079576611519,
-0.7730038166046143,
0.34719863533973694,
-0.4033536911010742,
-0.06689341366291046,
0.17751185595989227,
-0.19857890903949738,
0.11732027679681778,
-0.27537801861763,
-0.48985204100608826,
0.440296471118927,
-0.634283185005188,
-0.17621152102947235,
-1.8712046146392822,
0.8773980736732483,
-0.4349156618118286,
-0.018467528745532036,
-0.5831338167190552,
0.2139756977558136,
0.5251417756080627,
0.0018972329562529922,
-0.20648165047168732,
0.218644917011261,
-0.23509268462657928,
-0.535717785358429,
0.20453231036663055,
-0.27789971232414246,
0.3855134844779968,
0.0891890823841095,
0.17038574814796448,
0.2772938907146454,
-0.27162379026412964,
0.22050771117210388,
-0.1466291844844818,
-0.300412654876709,
-0.7486127018928528,
-0.6634827852249146,
0.3084965944290161,
-0.16420888900756836,
-0.12327771633863449,
0.6273145079612732,
-0.37999120354652405,
0.42261847853660583,
-0.17167924344539642,
-0.06591077148914337,
0.3380686640739441,
-0.1157904863357544,
-0.07366915792226791,
-0.41898393630981445,
0.46131375432014465,
-0.17235322296619415,
0.3941800594329834,
-0.2524091303348541,
-0.057379115372896194,
0.577142059803009,
-0.036185141652822495,
0.06113656982779503,
0.018046807497739792,
-0.5402939915657043,
0.49510079622268677,
0.44116196036338806,
0.5513400435447693,
0.34831491112709045,
0.2984369695186615,
-0.2441864013671875,
-0.04595480486750603,
0.0012774014612659812,
0.27010634541511536,
-0.35826364159584045,
-0.20036794245243073,
-0.6034401059150696,
-0.5900459885597229,
-0.5437059998512268,
-0.12621153891086578,
-0.5418686866760254,
-0.20934778451919556,
0.11528036743402481,
-1.07582426071167,
0.29057613015174866,
-0.20446805655956268,
0.22811302542686462,
-0.21150150895118713,
0.40860286355018616,
0.128506600856781,
-0.2551412582397461,
0.4030010998249054,
0.12306343764066696,
-0.0032479828223586082,
1.0566297769546509,
-0.014323686249554157,
0.46827661991119385,
-0.29774942994117737,
0.2549664378166199,
0.18037757277488708,
0.09583653509616852,
-0.41101306676864624,
0.36026909947395325,
0.2364417463541031,
0.5753805041313171,
0.27403533458709717,
-0.09426697343587875,
-0.08197485655546188,
-0.15403716266155243,
0.5467604398727417,
-0.4724937379360199,
0.25388303399086,
0.14226371049880981,
-0.05601219832897186,
-0.7354956269264221,
-0.7480242848396301,
-0.31897127628326416,
0.11579591780900955,
-0.2645505666732788,
0.20839747786521912,
-0.27363380789756775,
-0.08896733820438385,
-0.3813987076282501,
-0.25677844882011414,
0.02138848416507244,
-0.3475572466850281,
-0.24593177437782288,
0.37161365151405334,
0.32072585821151733,
-0.5597253441810608,
-0.25064218044281006,
0.3794185519218445,
0.27468451857566833,
0.2687707245349884,
0.03792349994182587,
-0.6018387079238892,
-0.12840516865253448,
0.5042181611061096,
-0.4862610399723053,
0.27493399381637573,
0.6044835448265076,
-0.4302717447280884,
0.06691769510507584,
-0.17238382995128632,
-0.19537603855133057,
0.3661441206932068,
-0.12194458395242691,
-0.3034648299217224,
0.3575180768966675,
0.39528772234916687,
-0.13882975280284882,
0.23716099560260773,
0.23722589015960693,
-0.770006000995636,
-0.029302502050995827,
0.3405161499977112,
-0.0977986678481102,
0.7202150225639343,
0.19178615510463715,
0.5828987956047058,
0.05174259841442108,
-0.01849852316081524,
0.06716659665107727,
-0.23429028689861298,
-0.2813400626182556,
0.7304624915122986,
-0.852529764175415,
0.9431933760643005,
0.011855458840727806,
0.15669073164463043,
1.5738924741744995,
-0.15969933569431305,
-0.0852377712726593,
-0.07634150981903076,
-0.28032079339027405,
0.48413458466529846,
-0.09327588975429535,
-0.5724526643753052,
-0.4463016092777252,
-0.29190120100975037,
-0.4353525936603546,
-0.44543811678886414,
-0.10027050226926804,
0.18902333080768585,
-0.423061341047287,
-0.41880157589912415,
0.3925487697124481,
0.28755244612693787,
0.3707299828529358,
-0.003022862132638693,
0.2324303686618805,
-0.5976124405860901,
0.12434195727109909,
0.6951690316200256,
-0.6067031025886536,
0.03359194099903107,
0.45998936891555786,
0.3129219114780426,
0.5014636516571045,
0.7792084813117981,
0.49675488471984863,
1.1089452505111694,
-0.6171605587005615,
0.17272233963012695,
-0.3659462034702301,
0.7563099265098572,
-0.816203236579895,
0.1524539440870285,
0.4452193081378937,
0.3927474915981293,
-0.2820395827293396,
-0.01936493255198002,
-0.13272671401500702,
-0.042745720595121384,
0.42892029881477356,
-0.34087392687797546,
-0.08869124203920364,
0.1876286268234253,
-0.2641732394695282,
-0.05144394189119339,
0.36654791235923767,
-0.745819628238678,
-0.25032755732536316,
0.31975170969963074,
0.633266031742096,
-0.1910673975944519,
-0.2774082124233246,
0.06508960574865341,
0.4138510227203369,
0.08534624427556992,
-0.369513601064682,
-0.06276176124811172,
-0.22064848244190216,
0.6699402332305908,
0.08198944479227066,
-0.02106367237865925,
-0.1501869410276413,
-0.1873011440038681,
-1.0344635248184204,
-0.5497276782989502,
-0.017046280205249786,
0.8808163404464722,
0.37755200266838074,
0.3934859335422516,
0.03482695668935776,
-0.5345154404640198,
0.39299261569976807,
-0.39761847257614136,
-0.9781996607780457,
-0.43525776267051697,
0.47590067982673645,
-0.7597348690032959,
-0.18839257955551147,
-0.33629682660102844,
-0.005853001959621906,
0.5815349221229553,
-0.23315872251987457,
-0.18922950327396393,
0.025612222030758858,
0.09353882074356079,
-0.23170706629753113,
-0.1516779363155365,
0.09302549809217453,
-0.019033318385481834,
0.41066959500312805,
-0.2804887890815735,
-0.3713892996311188,
0.1899596005678177,
0.030776625499129295,
0.19542819261550903,
0.5510741472244263,
0.2501438558101654,
0.3270837068557739,
-0.3122256100177765,
0.20554842054843903,
-0.20981068909168243,
-0.48316100239753723,
-0.2884928286075592,
0.012210795655846596,
-0.1115228533744812,
0.13155706226825714,
-5.85662317276001,
0.3540745973587036,
-0.14967402815818787,
-0.5870679616928101,
-0.720116913318634,
-0.23596540093421936,
0.9255755543708801,
0.2633885443210602,
0.05380350723862648,
0.06896213442087173,
0.44475051760673523,
-0.16900645196437836,
-0.28267702460289,
0.12136393785476685,
-0.1386062055826187,
0.24952350556850433,
-0.06932829320430756,
-0.014086112380027771,
0.030885634943842888,
0.11674898862838745,
0.4696946442127228,
-0.4939604103565216,
0.05414503440260887,
0.7487671375274658,
-0.06888683140277863,
0.3379475176334381,
-0.5537834167480469,
-0.1256537288427353,
-0.26258715987205505,
-0.3232456147670746,
0.02613251470029354,
-0.6208747625350952,
-0.45621034502983093,
-0.05792224034667015,
0.05392175912857056,
0.01048864983022213,
-0.1401086151599884,
0.14571253955364227,
0.5762636065483093,
-0.2673620879650116,
0.23770424723625183,
0.2664766013622284,
-0.1621372401714325,
-0.5179884433746338,
0.2640140950679779,
-0.1577112376689911,
-0.04220446199178696,
0.6138413548469543,
-0.5732836723327637,
0.40380269289016724,
-0.12153614312410355,
-0.4237264096736908,
0.22426824271678925,
0.4188109040260315,
-0.07662320882081985,
-0.14221741259098053,
0.03116314485669136,
-0.31493863463401794,
-0.7376070022583008,
0.2943015992641449,
0.08979171514511108,
-0.13414396345615387,
0.1617937982082367,
-1.0129187107086182,
-0.35535213351249695,
-0.06812246888875961,
-0.9228454232215881,
-0.4248429834842682,
0.35063034296035767,
0.12371569871902466,
-0.35964545607566833,
0.6567228436470032,
0.3208181858062744,
-0.5003863573074341,
0.12517386674880981,
-0.3492169678211212,
0.4502776265144348,
-0.16348473727703094,
-0.08746387809515,
-0.19294148683547974,
-0.2823192775249481,
-0.14349022507667542,
-0.22532004117965698,
-0.15959490835666656,
0.15865083038806915,
-0.5652266144752502,
-0.5533120036125183,
-0.25301381945610046,
-0.263410747051239,
0.27236804366111755,
0.4938370883464813,
-0.36740997433662415,
0.17216965556144714,
0.19475552439689636,
0.3274148106575012,
0.14283932745456696,
0.3267344832420349,
0.37415438890457153,
0.3344442844390869,
0.2611393332481384,
0.2166813313961029,
-0.19047819077968597,
-0.15103468298912048,
-0.8970297574996948,
-0.09214597940444946,
0.5131474733352661,
-0.6245492100715637,
0.1938846856355667,
0.864751398563385,
-0.8623539209365845,
-0.11489131301641464,
0.19304414093494415,
-0.1497536152601242,
-0.43469539284706116,
0.023035449907183647,
-0.012865887023508549,
0.03006059117615223,
0.3138175308704376,
0.761783242225647,
-0.48282015323638916,
0.04939787834882736,
0.17690686881542206,
-0.4795069396495819,
0.35519325733184814,
0.2556942403316498,
-0.4235018491744995,
0.28706231713294983,
0.7795678973197937,
-0.39257174730300903,
-0.16525645554065704,
0.401626855134964,
0.279766321182251,
-0.5290956497192383,
-0.2469796985387802,
0.17259402573108673,
-0.28832754492759705,
-0.5482876300811768,
0.22472719848155975,
-0.14516858756542206,
-0.03908178582787514,
0.39460185170173645,
-0.11379324644804001,
0.29629573225975037,
0.11224216967821121,
0.22268719971179962,
-0.008463757112622261,
0.12203682959079742,
-0.0780898928642273,
0.24479623138904572,
0.1605427861213684,
0.21909528970718384,
-0.5486283302307129,
0.005476037506014109,
-0.06558293104171753,
0.09347410500049591,
0.5543196201324463,
0.5587974190711975,
0.42899641394615173,
0.1747201532125473,
-0.4664466083049774,
0.31976988911628723,
0.13610081374645233,
-0.5956153869628906,
-0.0747247263789177,
-0.209655299782753,
0.12082332372665405,
0.023364877328276634,
0.09792038053274155,
-0.10189161449670792,
0.08588205277919769,
-0.26003941893577576,
-0.47872093319892883,
0.004287260584533215,
-0.009578567929565907,
-0.03407222777605057,
-0.028627661988139153,
-0.1414978951215744,
0.07449153065681458,
0.11291463673114777,
0.6626373529434204,
-0.011499259620904922,
-0.7504246830940247,
-0.4807223677635193,
0.6167173385620117,
0.8866251111030579,
0.39277467131614685,
-0.06815686821937561,
0.06227106228470802,
0.14451864361763,
-0.08529013395309448,
0.22553785145282745,
0.47019967436790466,
0.11022558063268661,
-0.06607802212238312,
-0.12573331594467163,
-0.49300050735473633,
0.06047015264630318,
0.3408254086971283,
0.1331142634153366,
-0.29381683468818665,
-0.10112448781728745,
0.4139677882194519,
-0.0008779314230196178,
0.148238405585289,
0.7397096157073975,
-0.19705244898796082,
-0.22231252491474152,
-0.11993101239204407,
-0.5252381563186646,
-0.16389967501163483,
-0.454986572265625,
-0.515410304069519,
-0.0731356292963028,
0.34750688076019287,
0.0821429118514061,
-0.1852651834487915,
0.27504003047943115,
-0.371085524559021,
-0.5372545123100281,
0.9811556339263916,
0.23259060084819794,
0.05042513459920883,
-0.06864805519580841,
0.1541338860988617,
-0.3664264380931854,
-0.2505425214767456,
0.3278660774230957,
-0.6278748512268066,
-0.07370040565729141,
0.13625407218933105,
-0.011537833139300346,
0.029598360881209373,
0.21183878183364868,
0.3983837366104126,
-0.19094178080558777,
-0.468751460313797,
0.16704551875591278,
0.203892782330513,
-0.11048171669244766,
0.07498914003372192,
0.41630539298057556,
0.3884437084197998,
-0.11456242948770523,
0.2408679723739624,
0.11297780275344849,
0.22464245557785034,
-0.20461449027061462,
-0.3654820919036865,
-0.2809661328792572,
-0.07647759467363358,
-0.03592459484934807,
0.1653153896331787,
-0.07703185826539993,
0.5454978942871094,
1.071268081665039,
0.5264637470245361,
-0.2154838889837265,
-0.43426641821861267,
0.025712383911013603,
0.22019195556640625,
0.021782882511615753,
0.0015840859850868583,
0.09267516434192657,
-0.25645238161087036,
0.7308855652809143,
0.33617934584617615,
-0.2595745623111725,
-0.22568736970424652,
0.5399459600448608,
-0.37538787722587585,
0.23112468421459198,
0.008474708534777164,
0.43073752522468567,
0.48475950956344604,
-0.10583508014678955,
0.06021065264940262,
0.027802078053355217,
0.2992440462112427,
-0.1461753398180008,
-0.011998482048511505,
-0.25342145562171936,
-0.6218991875648499,
0.6831647157669067,
-0.4644150137901306,
0.29398030042648315,
-0.45515626668930054,
0.2730409801006317,
-0.4916563630104065,
0.3419312536716461,
-0.836260199546814,
-0.5788863897323608,
0.2816925048828125,
-0.4367624819278717,
-0.03173321485519409,
-0.17177380621433258,
0.2681170105934143,
0.7302806377410889,
0.5438363552093506,
-0.6153562068939209,
-0.13470052182674408,
-0.6649524569511414,
0.3069303631782532,
0.6452080011367798,
-0.9939976930618286,
0.15066000819206238,
0.19109651446342468,
0.4646545350551605,
0.18617820739746094,
-0.3670656979084015,
-0.20085453987121582,
0.0372372530400753,
0.0035503117833286524,
0.3599381446838379,
0.13424107432365417,
-0.17050151526927948,
0.1696569174528122,
-0.4657735526561737,
0.18094709515571594,
0.7462431192398071,
-0.06559969484806061,
-0.20039111375808716,
1.2067593336105347,
0.5538263916969299,
-0.33003515005111694,
-0.034369271248579025,
0.5227839350700378,
0.40813571214675903,
0.6910732388496399,
-0.019003961235284805,
0.6436718702316284,
0.24423950910568237,
0.47666022181510925,
0.04579879343509674,
0.5590432286262512,
0.07590961456298828,
-0.09219039976596832,
-0.05523965507745743,
-0.25517523288726807,
-0.39512330293655396,
-0.10106360912322998,
0.6758717894554138,
0.2592385411262512,
-0.42047640681266785,
-0.21338129043579102,
0.06071171909570694,
0.22736713290214539,
-0.042183395475149155,
0.7571726441383362,
0.12583978474140167,
0.13774807751178741,
0.4008116126060486,
-0.31022971868515015,
-0.23332901298999786,
0.4211719036102295,
-0.1572524905204773,
-0.4082232713699341,
0.45131734013557434,
-0.45115482807159424,
-0.4677514135837555,
-0.06179916113615036,
-0.36824142932891846,
0.43619394302368164,
-0.21673457324504852,
0.2590194344520569,
-0.2884605824947357,
0.3589007556438446,
0.76847243309021,
-0.08801031857728958,
0.5330452919006348,
-0.18720367550849915,
0.004037340637296438,
0.0953167974948883,
-0.3100442588329315,
0.45564937591552734,
-0.13688641786575317,
-0.7484906911849976,
0.19466640055179596,
0.07028105109930038,
-0.22358974814414978,
0.2225492298603058,
-0.36207330226898193,
0.11372371762990952,
0.06078869104385376,
-0.3356759548187256,
-0.044619929045438766,
-0.342693954706192,
-0.136880025267601,
-0.26801440119743347,
0.33666953444480896,
0.08602166175842285,
0.1861851066350937,
-1.0613830089569092,
-0.07529911398887634,
0.23975223302841187,
-0.2596457302570343,
-0.022284824401140213,
-0.3162800073623657,
0.2325332909822464,
0.09648973494768143,
0.47147950530052185,
-0.029864871874451637,
-0.1777954399585724,
0.08356695622205734,
0.335094153881073,
-0.33992138504981995,
0.3336520493030548,
-0.45184242725372314,
-0.3845553994178772,
-0.49641385674476624,
0.12134747207164764,
0.9331581592559814,
0.08763919770717621,
-0.49693214893341064,
0.4392399489879608,
-0.324566513299942,
-0.42180854082107544,
0.3515981137752533,
0.1484564244747162,
0.03837249428033829,
-0.4243103563785553,
-0.1978207677602768,
-0.508216381072998,
0.5449004173278809,
-0.3223288357257843,
-0.5316594839096069,
-0.10589513182640076,
0.4650355875492096,
0.19308970868587494,
-0.08839843422174454,
0.7589966058731079,
-0.10996095091104507,
0.1947166621685028,
-0.4383048415184021,
0.026970429345965385,
-0.9804869294166565,
-0.2604909837245941,
0.0891219824552536,
-0.08442407101392746,
-0.049198299646377563,
-0.04887577146291733,
-0.07302287966012955,
-0.12612564861774445,
-0.09313460439443588,
0.5210261344909668,
0.3649645745754242,
0.3634876608848572,
0.14136183261871338,
-0.4004157781600952,
-0.6460676193237305,
0.04611334949731827,
-0.1278437376022339,
0.2728826403617859,
-0.6065937280654907,
-0.028477836400270462,
-0.17643125355243683,
0.05923830345273018,
-0.01369571778923273,
-0.8229123950004578,
-0.28191691637039185,
0.09625610709190369
] |
[Image: see text] RNA pseudoknots have important functions, and thermodynamic stability is a key to predicting pseudoknots in RNA sequences and to understanding their functions. Traditional methods, such as UV melting and differential scanning calorimetry, for measuring RNA thermodynamics are restricted to temperature ranges around the melting temperature for a pseudoknot. Here, we report RNA pseudoknot free energy changes at 37 °C measured by fluorescence competition assays. Sequence-dependent studies for the loop 1−stem 2 region reveal (1) the individual nearest-neighbor hydrogen bonding (INN-HB) model provides a reasonable estimate for the free energy change when a Watson−Crick base pair in stem 2 is changed, (2) the loop entropy can be estimated by a statistical polymer model, although some penalty for certain loop sequences is necessary, and (3) tertiary interactions can significantly stabilize pseudoknots and extending the length of stem 2 may alter tertiary interactions such that the INN-HB model does not predict the net effect of adding a base pair. The results can inform writing of algorithms for predicting and/or designing RNA secondary structures. | [
0.015419120900332928,
0.010685538873076439,
-0.01402463298290968,
0.025652294978499413,
-0.011858236975967884,
-0.010041110217571259,
0.013487689197063446,
-0.017958801239728928,
-0.01912425458431244,
-0.0033428038004785776,
0.006100283935666084,
0.012227697297930717,
-0.0368913970887661,
0.02985616773366928,
-0.010013117454946041,
0.024891488254070282,
-0.02912491001188755,
0.000019514933228492737,
0.012232712469995022,
0.013813493773341179,
-0.011549623683094978,
-0.033955298364162445,
0.01207289844751358,
0.024141043424606323,
0.03188902139663696,
-0.0036845675203949213,
-0.020356757566332817,
-0.00610077939927578,
0.005280281882733107,
-0.007082626689225435,
0.009252311661839485,
-0.022885896265506744,
0.01694352552294731,
-0.005762497428804636,
0.013758346438407898,
0.015500642359256744,
-0.01290199439972639,
0.020742226392030716,
0.02797183394432068,
-0.0061812447383999825,
0.0008958284743130207,
-0.017259124666452408,
0.008232133463025093,
0.015310259535908699,
-0.010759688913822174,
-0.03460031747817993,
-0.0065076653845608234,
0.008232546038925648,
-0.002209101803600788,
0.009144495241343975,
-0.018292313441634178,
0.01854119822382927,
-0.0068207127042114735,
0.0037963199429214,
-0.007948542945086956,
-0.030761688947677612,
0.020617954432964325,
-0.01038145087659359,
-0.06773895025253296,
0.026025215163826942,
-0.002078210934996605,
0.013882772997021675,
-0.015085497871041298,
-0.003199394792318344,
0.031954534351825714,
-0.06629444658756256,
0.025338971987366676,
0.0016475925222039223,
0.0004114184994250536,
-0.008796460926532745,
-0.005635863170027733,
0.017771542072296143,
-0.04039134830236435,
0.009213455952703953,
0.046585939824581146,
0.028960393741726875,
-0.020060423761606216,
0.021171599626541138,
-0.008636606857180595,
-0.007188394200056791,
0.008060986176133156,
-0.015123967081308365,
0.013937857933342457,
0.01495581865310669,
0.0391409695148468,
-0.0020700953900814056,
-0.02066202275454998,
0.0004922961816191673,
-0.007264643907546997,
0.02211187407374382,
0.06313332915306091,
-0.037489183247089386,
0.025781307369470596,
0.016885830089449883,
0.00009546568617224693,
-0.0065386975184082985,
0.04121411591768265,
0.011021079495549202,
0.034032292664051056,
0.013430084101855755,
-0.010856108739972115,
0.03703264147043228,
0.026651201769709587,
-0.01970246061682701,
-0.009401299059391022,
0.01399293914437294,
-0.008405602537095547,
0.006109736859798431,
0.010907426476478577,
0.003268088912591338,
0.0013232140336185694,
-0.0003916877321898937,
0.009964888915419579,
-0.012730622664093971,
0.020692363381385803,
0.001227014698088169,
-0.016930753365159035,
-0.005009839776903391,
0.006052272394299507,
-0.018470363691449165,
-0.019367065280675888,
0.04421842843294144,
-0.0006085901986807585,
-0.00579421129077673,
0.00618320144712925,
0.04958948493003845,
0.006404670886695385,
-0.01465129666030407,
0.004350326955318451,
0.01402275264263153,
-0.015132303349673748,
0.014693223871290684,
-0.01287760678678751,
-0.031822942197322845,
-0.004797347355633974,
-0.006867141928523779,
0.023139577358961105,
-0.02072015032172203,
0.023355476558208466,
-0.007942307740449905,
0.033841706812381744,
0.011753281578421593,
0.00984443910419941,
0.012583738192915916,
-0.01438656821846962,
0.0005523302825167775,
-0.00323855085298419,
-0.014083907939493656,
0.02487562596797943,
-0.04764833301305771,
-0.004353011026978493,
-0.03526625409722328,
-0.04091959074139595,
-0.020208297297358513,
0.00758584588766098,
0.005461930762976408,
-0.031429972499608994,
0.010690571740269661,
-0.0007881880737841129,
-0.0017927675507962704,
-0.0024834945797920227,
0.03795096278190613,
0.023211680352687836,
0.011609857901930809,
0.006372051313519478,
-0.011339284479618073,
0.026510639116168022,
-0.002184630837291479,
-0.032288312911987305,
0.007415333762764931,
-0.013759664259850979,
-0.01249249279499054,
0.01979125663638115,
0.009702296927571297,
0.012349658645689487,
0.0014952931087464094,
-0.009324495680630207,
0.0062783220782876015,
-0.03176756948232651,
0.066425621509552,
0.04256988689303398,
0.022018376737833023,
-0.0026918137446045876,
0.03556308150291443,
0.030102308839559555,
-0.019923780113458633,
-0.03189010173082352,
-0.005319905001670122,
0.02083592116832733,
0.01718870922923088,
-0.01070713996887207,
0.005842359270900488,
-0.005362117663025856,
-0.01537366397678852,
0.04220746085047722,
0.0037297909148037434,
0.041129231452941895,
0.008941978216171265,
-0.023858066648244858,
0.04329011216759682,
0.03370993584394455,
0.01793241873383522,
0.02872173674404621,
0.040143705904483795,
0.02543572708964348,
0.015699688345193863,
0.0016896971501410007,
0.006801809649914503,
0.0070711527951061726,
0.005669013597071171,
0.017347518354654312,
-0.06125039607286453,
-0.01779898628592491,
-0.008021342568099499,
0.008953920565545559,
0.008919722400605679,
0.01074956264346838,
0.020351439714431763,
-0.01559776533395052,
-0.013073255307972431,
0.007884406484663486,
0.01893019676208496,
0.00025055091828107834,
-0.01664286106824875,
0.005741803906857967,
-0.013172897510230541,
-0.013398762792348862,
0.012353222817182541,
0.005453973077237606,
0.02201227657496929,
0.01069868914783001,
0.007331869099289179,
-0.01580938696861267,
-0.007302151992917061,
-0.021964076906442642,
0.004648706875741482,
0.015576748177409172,
-0.019906047731637955,
0.03748731315135956,
-0.012315953150391579,
-0.015593606978654861,
-0.005305184051394463,
0.010663146153092384,
-0.015085377730429173,
0.02793365716934204,
-0.0033319778740406036,
-0.004051627591252327,
0.035786814987659454,
0.024483999237418175,
-0.007575114723294973,
0.012405380606651306,
-0.026751110330224037,
0.0010788138024508953,
-0.013573127798736095,
-0.0335126593708992,
0.01951107382774353,
0.0070139821618795395,
-0.006614901125431061,
0.024295907467603683,
-0.013490226119756699,
0.0080646937713027,
0.010244078934192657,
-0.0117162074893713,
0.009085290133953094,
-0.0364120751619339,
0.03661300987005234,
-0.021709982305765152,
-0.008100168779492378,
0.01603754237294197,
-0.004955357406288385,
0.012075792998075485,
-0.02160636894404888,
-0.019733043387532234,
-0.08027119934558868,
-0.01824534684419632,
0.041570283472537994,
-0.017992407083511353,
0.01430019736289978,
-0.01058872975409031,
0.010039448738098145,
0.01821536011993885,
-0.006364455446600914,
-0.025925951078534126,
0.03878983110189438,
0.015857450664043427,
-0.017116094008088112,
0.01392496470361948,
-0.001595843117684126,
-0.0127170505002141,
0.027866482734680176,
0.004076709970831871,
-0.034721553325653076,
-0.017067771404981613,
-0.0006999322213232517,
-0.011967763304710388,
-0.0076435101218521595,
0.02094728872179985,
-0.022866452112793922,
-0.019234443083405495,
0.0048108650371432304,
-0.009154626168310642,
-0.05400991439819336,
0.01796894334256649,
-0.013914262875914574,
-0.0212518572807312,
-0.0071425484493374825,
0.01625266671180725,
0.05976295471191406,
-0.007248455658555031,
-0.026379602029919624,
-0.0029890257865190506,
-0.009463661350309849,
0.026466330513358116,
0.006441363599151373,
0.00811106525361538,
0.010856942273676395,
-0.021652542054653168,
0.0017473017796874046,
0.03671185299754143,
0.017378268763422966,
0.015460638329386711,
0.02728980779647827,
-0.016939260065555573,
0.027684029191732407,
0.013011339120566845,
0.017997242510318756,
0.017300689592957497,
-0.022829893976449966,
-0.004187425598502159,
0.01775307208299637,
0.018956024199724197,
-0.008160488680005074,
-0.010685853660106659,
-0.005106157157570124,
0.006234805099666119,
0.029945172369480133,
0.027345482259988785,
-0.0038874740712344646,
0.0042692190036177635,
0.010822532698512077,
0.0036127425264567137,
-0.02443852648139,
0.017648015171289444,
0.025034934282302856,
0.010732182301580906,
-0.028158990666270256,
-0.009971587918698788,
-0.021043015643954277,
-0.020604686811566353,
-0.014942974783480167,
-0.025317013263702393,
-0.02403106912970543,
-0.023991107940673828,
-0.02671584114432335,
0.003559956792742014,
-0.017743157222867012,
-0.010407503694295883,
-0.03882107883691788,
0.04609798640012741,
0.002524745184928179,
0.010573416948318481,
0.0076758842915296555,
-0.014682518318295479,
-0.00017500866670161486,
0.0071049160324037075,
-0.008481776341795921,
0.010583082213997841,
0.011054053902626038,
-0.0029773754067718983,
0.004870968870818615,
-0.011956392787396908,
0.021471278741955757,
0.011203551664948463,
-0.019329065456986427,
-0.005051332525908947,
0.025597471743822098,
-0.015054939314723015,
-0.0453648567199707,
0.011143839918076992,
-0.007480496075004339,
-0.01970193162560463,
0.004988246597349644,
-0.0030071805231273174,
-0.015531155280768871,
-0.018603995442390442,
-0.015099940821528435,
0.022151891142129898,
0.003971452824771404,
0.02511158585548401,
0.002765442943200469,
-0.013060138560831547,
0.07128977030515671,
0.027835896238684654,
0.02217533253133297,
-0.040538255125284195,
-0.012057483196258545,
-0.009416518732905388,
-0.0029079620726406574,
0.007955317385494709,
0.0012997849844396114,
-0.021941138431429863,
0.013062983751296997,
0.0035256799310445786,
-0.010192552581429482,
-0.0010905044618993998,
-0.03556405007839203,
0.010916272178292274,
0.0009486931376159191,
0.012178678065538406,
0.0015481002628803253,
0.02766876108944416,
-0.01614456996321678,
0.026378914713859558,
-0.015414214693009853,
-0.026931537315249443,
-0.04813747480511665,
0.008634291589260101,
-0.005511489696800709,
-0.01651301048696041,
-0.020237743854522705,
0.01404448039829731,
0.03621640056371689,
-0.015268344432115555,
-0.008743513375520706,
-0.023144235834479332,
0.02307974174618721,
0.019962787628173828,
0.0217121671885252,
-0.00907253660261631,
-0.004154103342443705,
0.02089526876807213,
0.02124442532658577,
-0.013299871236085892,
-0.021820709109306335,
0.00540585583075881,
0.03153365105390549,
0.01360631175339222,
0.01618945598602295,
-0.01229910645633936,
-0.007512652315199375,
0.01672675460577011,
0.005663829855620861,
-0.004871468525379896,
0.01028397399932146,
-0.011292299255728722,
-0.038180626928806305,
-0.017067234963178635,
0.029288941994309425,
-0.014518944546580315,
-0.005515466444194317,
-0.019216980785131454,
0.0028608953580260277,
-0.006630660966038704,
-0.01137848012149334,
-0.020450450479984283,
0.009565059095621109,
-0.015129217877984047,
-0.0060773626901209354,
0.01325974427163601,
0.012235892936587334,
-0.0304071307182312,
0.017210016027092934,
0.0015529133379459381,
0.00881887786090374,
0.004225065931677818,
-0.023315006867051125,
-0.022425580769777298,
-0.023221278563141823,
0.009863186627626419,
0.016459407284855843,
-0.00047737034037709236,
0.012677241116762161,
0.016818810254335403,
-0.03563327342271805,
0.009623787365853786,
0.020211655646562576,
-0.04596392810344696,
0.001760863233357668,
-0.07370864599943161,
0.000432728324085474,
0.003107735887169838,
-0.007284716237336397,
-0.01041928306221962,
0.07287013530731201,
-0.027143167331814766,
0.00745772197842598,
-0.016462106257677078,
-0.013299331068992615,
0.01073151919990778,
0.006931757554411888,
0.03556499630212784,
-0.02338331565260887,
0.008129386231303215,
-0.0014882953837513924,
0.0235334150493145,
0.02985002100467682,
0.009495975449681282,
0.03034553863108158,
-0.015444254502654076,
0.04264802113175392,
-0.030730215832591057,
-0.025125065818428993,
-0.01602308452129364,
-0.0800468921661377,
-0.017016315832734108,
-0.002344766166061163,
-0.018806761130690575,
-0.036922771483659744,
-0.0039624981582164764,
0.023796021938323975,
-0.01500436756759882,
0.013430830091238022,
-0.01802111230790615,
0.027817098423838615,
0.027271518483757973,
0.03753894194960594,
-0.03180906921625137,
0.012682970613241196,
-0.012663479894399643,
0.017611846327781677,
0.03214774280786514,
-0.030664261430501938,
0.03765985742211342,
-0.01919916272163391,
0.009998181834816933,
-0.013921370729804039,
-0.014370451681315899,
-0.013833824545145035,
-0.007721809670329094,
-0.005355171859264374,
0.014380784705281258,
-0.021054456010460854,
0.008058052510023117,
0.016199704259634018,
-0.015937279909849167,
0.005888796877115965,
-0.01718965545296669,
-0.000661246944218874,
-0.035558752715587616,
-0.006338583771139383,
-0.01008579321205616,
-0.0021795863285660744,
-0.020924394950270653,
-0.008169248700141907,
-0.02436678670346737,
-0.011867772787809372,
-0.0011115365196019411,
0.005923972465097904,
-0.020340189337730408,
0.006812587846070528,
-0.013158472254872322,
0.008426949381828308,
-0.022042881697416306,
0.013732850551605225,
-0.02585539035499096,
0.015352298505604267,
0.03260939568281174,
0.006864997558295727,
0.016991248354315758,
-0.0029340749606490135,
0.028569690883159637,
-0.020810473710298538,
0.017271315678954124,
0.0007435502484440804,
0.010680973529815674,
0.0034939032047986984,
0.07132477313280106,
0.005955154541879892,
-0.01454231794923544,
-0.05110675096511841,
-0.016328006982803345,
0.007875898852944374,
-0.03606389835476875,
0.0036675692535936832,
0.0122250746935606,
0.007376482710242271,
0.008401856757700443,
-0.023145301267504692,
0.0021624304354190826,
0.019929300993680954,
0.01718415878713131,
0.06155306100845337,
-0.011606460437178612,
0.007893301546573639,
-0.02161652036011219,
-0.03558061644434929,
0.005559924989938736,
0.024757394567131996,
-0.013316065073013306,
0.031359847635030746,
-0.008166183717548847,
-0.01998489536345005,
0.0007266243919730186,
0.00871480256319046,
0.026656795293092728,
0.02145916409790516,
0.009666938334703445,
-0.0016532461158931255,
0.007892003282904625,
-0.01066188607364893,
0.029767366126179695,
0.012813594192266464,
-0.009871129877865314,
0.011961419135332108,
-0.016750041395425797,
-0.04312556982040405,
-0.0000057192519307136536,
0.02552325278520584,
-0.0006222454831004143,
-0.015655633062124252,
-0.013250937685370445,
0.0021695089526474476,
0.009254219941794872,
0.023125555366277695,
0.0072051240131258965,
0.005366480443626642,
-0.0035710365045815706,
0.004243751522153616,
-0.026579635217785835,
-0.0083441948518157,
0.014370950870215893,
-0.019053250551223755,
-0.012296002358198166,
0.014553575776517391,
-0.012931705452501774,
-0.04170139878988266,
0.025890415534377098,
-0.007177464663982391,
-0.000030431896448135376,
-0.011140802875161171,
0.037469860166311264,
0.014197507873177528,
-0.023047860711812973,
-0.011698640882968903,
-0.018365222960710526,
0.017067236825823784,
-0.03647430241107941,
0.013197646476328373,
0.013746978715062141,
0.02489391341805458,
0.039314620196819305,
-0.01881004124879837,
-0.02011188492178917,
-0.01905057020485401,
0.014227550476789474,
0.006370089948177338,
-0.0065817441791296005,
0.04287015646696091,
0.037755437195301056,
-0.01711895689368248,
0.0072167422622442245,
0.02914494462311268,
0.0018254006281495094,
0.0010356167331337929,
-0.0017871125601232052,
0.00830196961760521,
-0.02369864284992218,
0.0080782575532794,
0.013244789093732834,
0.006850026082247496,
-0.002037979895249009,
0.03443705290555954,
0.056637685745954514,
0.00885368138551712,
-0.015482594259083271,
-0.008444642648100853,
0.015611739829182625,
-0.013723844662308693,
0.011850887909531593,
0.01195000670850277,
-0.04421144723892212,
-0.00683392770588398,
0.008959131315350533,
0.030208613723516464,
-0.015109940432012081,
-0.02578268013894558,
0.01663397252559662,
-0.01760024018585682,
-0.018866313621401787,
0.002471973653882742,
-0.0028657414950430393,
-0.0116875683888793,
-0.02700699493288994,
-0.019609156996011734,
0.01563069224357605,
-0.008832625113427639,
-0.0037383786402642727,
0.009633615612983704,
-0.025456391274929047,
0.006945677567273378,
0.03940930217504501,
-0.027150306850671768,
-0.005245525389909744,
-0.0321529358625412,
0.030462596565485,
-0.02662697061896324,
0.023335322737693787,
0.021107682958245277,
0.011163830757141113,
0.0013450278202071786,
-0.0030144955962896347,
0.004974606446921825,
-0.0016599235823377967,
0.016444765031337738,
0.007790871895849705,
-0.004139581695199013,
0.0024397114757448435,
-0.023799490183591843,
0.0076464517042040825,
-0.007399753667414188,
0.008672937750816345,
0.025022754445672035,
0.0021770470775663853,
0.03767108544707298,
0.001330699073150754,
-0.014126714318990707,
0.004976051859557629,
0.03203805163502693,
0.00754534313455224,
-0.006962657440453768,
0.005342697259038687,
0.02113872580230236,
0.0031962236389517784,
0.0068960487842559814,
-0.018967974931001663,
0.02100621536374092,
0.018245059996843338,
0.029488004744052887,
0.05212394893169403,
-0.011571891605854034,
-0.008406618610024452,
0.014423546381294727,
0.024898918345570564,
0.02875848487019539,
-0.0006439452990889549,
-0.02167564630508423,
-0.014538204297423363,
-0.016643786802887917,
-0.004330351948738098,
0.0001779678277671337,
-0.05468936264514923,
-0.02382105402648449,
-0.023711364716291428,
-0.013802563771605492,
-0.027576182037591934,
-0.011138012632727623,
-0.01271982491016388,
-0.011492307297885418,
-0.008480215445160866,
-0.014119710773229599,
0.0145245511084795,
0.009579591453075409,
0.0004937316407449543,
0.01725916564464569,
0.00041335891000926495,
-0.01928979530930519,
-0.024130823090672493,
-0.01188832800835371,
-0.018505621701478958,
0.002707586158066988,
-0.032161422073841095,
0.02352093905210495,
0.004239900968968868,
0.002852741163223982,
0.017660237848758698,
-0.005678860936313868,
-0.02235061675310135,
-0.010697348043322563
] | [
0.3138394355773926,
0.522271454334259,
-0.029559114947915077,
-0.232034370303154,
-0.05786031484603882,
-0.2672766447067261,
0.4456877112388611,
-0.5266668200492859,
-0.03214629366993904,
-0.17335133254528046,
0.024460725486278534,
-0.007478092331439257,
-0.6544075608253479,
0.425497442483902,
-0.15469272434711456,
0.5166361331939697,
0.4093511998653412,
0.6212729215621948,
0.1791633516550064,
-0.6540512442588806,
-0.12444800138473511,
0.11299444735050201,
0.30116409063339233,
-0.07128679752349854,
0.3606277108192444,
0.16457365453243256,
0.2827613651752472,
-0.09988683462142944,
-0.04083961993455887,
-0.046182602643966675,
-0.31826868653297424,
0.7732855677604675,
0.18919996917247772,
-0.08468075841665268,
0.4036850333213806,
0.031143484637141228,
-0.4614436626434326,
0.007969090715050697,
0.09585194289684296,
-0.12171582132577896,
-0.014296804554760456,
-0.3391127288341522,
-0.08441150933504105,
0.5315495729446411,
-0.5992611050605774,
-0.7906422019004822,
-1.193822979927063,
1.1414158344268799,
-0.17559002339839935,
0.024126840755343437,
-0.04656833037734032,
-0.09015265107154846,
0.8559786081314087,
-0.011223661713302135,
0.13462203741073608,
0.1716577559709549,
-0.4750556945800781,
-0.06319330632686615,
0.6099186539649963,
-0.46123939752578735,
0.3180636167526245,
-0.05943211540579796,
-0.4698832035064697,
0.37535399198532104,
0.09549825638532639,
0.885358989238739,
0.30608049035072327,
-0.4247303903102875,
-0.7858586311340332,
0.3943628966808319,
0.7491067051887512,
0.2469578981399536,
-0.1630696803331375,
-0.018907323479652405,
-0.2544940412044525,
0.1874583661556244,
-0.1589966118335724,
0.3793773353099823,
0.12468571960926056,
-0.24312227964401245,
0.009459608234465122,
-0.0006790764746256173,
-0.11533722281455994,
-0.2955118417739868,
0.11090398579835892,
-0.035523220896720886,
-0.5164243578910828,
0.607001781463623,
-0.7599928975105286,
0.009037255309522152,
0.022600499913096428,
-0.1384405642747879,
-0.2247643619775772,
0.4433961808681488,
0.013647698797285557,
0.16437794268131256,
-0.08913952857255936,
0.060593120753765106,
0.2789510190486908,
0.2879427671432495,
-0.3861631751060486,
-0.3226310908794403,
0.19648468494415283,
-0.5706095695495605,
-0.021237937733530998,
0.02911173738539219,
-0.5079368352890015,
-0.7362273931503296,
-0.39171940088272095,
0.053790464997291565,
-0.5348255038261414,
0.20460204780101776,
-0.28082817792892456,
-0.032670408487319946,
-0.3878422677516937,
-0.06290925294160843,
0.20217356085777283,
-0.3018522560596466,
-0.11828996986150742,
0.1467580944299698,
-0.43833687901496887,
1.3659230470657349,
-0.01050011720508337,
0.23328325152397156,
0.05779000371694565,
0.12961062788963318,
0.2369752675294876,
0.4753032624721527,
-0.6858752369880676,
0.1514124870300293,
0.30419063568115234,
1.5990585088729858,
-0.45231348276138306,
-0.131211519241333,
-0.25854143500328064,
-0.12030337005853653,
-0.27769917249679565,
0.22394268214702606,
0.3713577389717102,
0.20090608298778534,
-0.5836471319198608,
-0.5744938850402832,
-0.19653353095054626,
0.35888344049453735,
-0.35544630885124207,
0.011912303976714611,
-0.39597630500793457,
-0.5310052037239075,
-0.29749342799186707,
-0.011854439042508602,
-0.37419208884239197,
-0.2813023328781128,
-0.9005852937698364,
0.08985203504562378,
0.21655645966529846,
-0.3338417708873749,
0.004538909066468477,
0.0991440862417221,
-0.04510034620761871,
0.31325873732566833,
0.36030539870262146,
-0.09821055084466934,
-0.5033563375473022,
-0.4472043812274933,
0.5949696898460388,
-0.14465053379535675,
0.5515460968017578,
0.32679522037506104,
-0.14656369388103485,
0.06807416677474976,
-0.24019849300384521,
-0.3369397222995758,
0.1622089445590973,
-0.4254925847053528,
-0.277876079082489,
-0.21272477507591248,
-0.07167085260152817,
-0.4723900258541107,
-0.24308446049690247,
0.38726791739463806,
-0.8548809885978699,
0.013864035718142986,
-0.09252499043941498,
-0.7502638101577759,
0.4852621853351593,
0.597411572933197,
0.22222945094108582,
0.4044352173805237,
0.2754107117652893,
-0.14291110634803772,
-0.26230451464653015,
-0.0616886131465435,
0.36212339997291565,
-0.7714059352874756,
0.9765150547027588,
0.20563672482967377,
0.0027143799234181643,
1.5889643430709839,
0.13320352137088776,
-0.41992390155792236,
-0.5709106922149658,
0.3427296578884125,
0.48417410254478455,
-0.7706459164619446,
-0.27052900195121765,
0.13938844203948975,
0.4467405676841736,
-0.07432178407907486,
0.11391492187976837,
-0.353532075881958,
0.9010265469551086,
-0.3834308981895447,
-0.21802718937397003,
-0.5184299349784851,
-0.03783664479851723,
-0.38187354803085327,
0.03635173663496971,
-0.1899813562631607,
-0.2734684646129608,
0.38654541969299316,
0.7877198457717896,
-0.4788983166217804,
0.7130540013313293,
0.5077024102210999,
0.0042908936738967896,
0.8184502720832825,
0.6900871396064758,
0.25038573145866394,
0.7032280564308167,
-0.2991642355918884,
0.371385782957077,
-1.102814793586731,
0.43073081970214844,
-0.3326069712638855,
-0.12084382772445679,
0.025210054591298103,
0.035025205463171005,
0.07439875602722168,
0.29286429286003113,
-0.16509121656417847,
0.05583887919783592,
0.27146250009536743,
-1.0134201049804688,
0.1511206030845642,
0.16277340054512024,
-0.4823865294456482,
-0.01967419497668743,
-0.16056375205516815,
-0.6219087243080139,
0.009789199568331242,
0.03523603081703186,
0.2208535522222519,
0.542763352394104,
-0.8821718692779541,
0.592807412147522,
0.03539876639842987,
-0.16367986798286438,
-0.13807140290737152,
0.11596622318029404,
-0.13472552597522736,
-0.44505876302719116,
0.00647755479440093,
0.2531004846096039,
0.05174582079052925,
-0.17492590844631195,
0.06001947075128555,
-0.6239914894104004,
-0.887290894985199,
1.4617680311203003,
0.6263618469238281,
0.43815386295318604,
0.38297539949417114,
-0.5585082173347473,
-0.07375679165124893,
0.049102477729320526,
-0.6251310110092163,
0.24480314552783966,
0.2986010015010834,
-0.4952782690525055,
-0.5316218733787537,
0.045118071138858795,
0.49355348944664,
0.5688862800598145,
-0.8983081579208374,
-0.5253559350967407,
0.0809188187122345,
-0.0004460781638044864,
0.1661749929189682,
-0.6181985139846802,
-0.26806020736694336,
-0.7349932789802551,
0.26015064120292664,
-0.06806238740682602,
-0.18906894326210022,
0.2113792449235916,
0.2807457745075226,
0.2558946907520294,
0.11895463615655899,
0.553838312625885,
-0.309900164604187,
0.1397436559200287,
0.4048307240009308,
-0.5303677320480347,
-0.18252934515476227,
0.1500331610441208,
0.50872403383255,
0.0027709384448826313,
0.4007700979709625,
-5.666562557220459,
0.35169652104377747,
-0.1755470186471939,
-0.3104439377784729,
-0.21992675960063934,
-0.08530796319246292,
0.9006617665290833,
-0.15391162037849426,
0.3135138154029846,
-0.224341481924057,
0.11668184399604797,
-0.20207834243774414,
0.18089653551578522,
0.4400845766067505,
0.24521440267562866,
0.10609815269708633,
0.5355677008628845,
0.12581633031368256,
0.44933757185935974,
0.2548990249633789,
0.24009104073047638,
0.4239329695701599,
0.12048908323049545,
-0.18746091425418854,
-0.11931493878364563,
-0.7352914810180664,
-0.8537845015525818,
-0.3121403753757477,
-0.44114866852760315,
-0.8578013181686401,
-0.050348859280347824,
-0.22072657942771912,
-0.17259128391742706,
-0.22264105081558228,
0.20773713290691376,
-0.038538672029972076,
0.06910116225481033,
-0.142663836479187,
0.24852316081523895,
0.06504447013139725,
0.41601985692977905,
0.23041261732578278,
0.2107357382774353,
0.1556490808725357,
0.35698193311691284,
-0.17765431106090546,
-0.07769417762756348,
-0.12955307960510254,
-0.2646147906780243,
0.8726243376731873,
-0.5385295748710632,
-0.17288674414157867,
0.6983064413070679,
0.1416025012731552,
0.46364787220954895,
-0.24914668500423431,
-0.2992466390132904,
0.3347229063510895,
-0.6388197541236877,
-0.25160449743270874,
-0.06338050216436386,
0.11318833380937576,
0.25776293873786926,
-0.6832444071769714,
-0.09840695559978485,
0.2219039350748062,
-0.9575310945510864,
-0.4459100663661957,
0.4489160180091858,
0.045719318091869354,
-0.3056136965751648,
-0.10179206728935242,
-0.0529150553047657,
-0.46349209547042847,
0.8863596320152283,
-0.1890379786491394,
0.627352237701416,
0.12081347405910492,
-0.14912067353725433,
0.14157937467098236,
-0.45171627402305603,
0.18583296239376068,
-0.404805064201355,
0.029004763811826706,
0.4295286536216736,
-0.5120121836662292,
-0.29799333214759827,
-0.3571995794773102,
-0.41161441802978516,
0.4658004343509674,
0.8959962725639343,
-0.2104683667421341,
0.07302307337522507,
0.5023657083511353,
0.3785061836242676,
-0.06809208542108536,
0.5762468576431274,
0.4333857595920563,
0.829038679599762,
0.28371307253837585,
0.8231648802757263,
0.08782370388507843,
-0.4271593391895294,
-0.9996042251586914,
-0.04243554547429085,
-0.10582870244979858,
-0.45325207710266113,
0.40420272946357727,
0.641978919506073,
-0.35551559925079346,
0.11031092703342438,
-0.11766869574785233,
-0.3380199074745178,
0.3355971574783325,
0.27098000049591064,
-0.17507922649383545,
0.16776059567928314,
-0.05567412078380585,
0.25810158252716064,
-0.29817789793014526,
0.20309945940971375,
0.3460923731327057,
-0.44863632321357727,
0.5452582836151123,
-0.19650332629680634,
-0.29483363032341003,
0.07743261754512787,
0.2707810401916504,
-0.4759713411331177,
-0.23823751509189606,
0.41404280066490173,
0.39550209045410156,
-0.5817933678627014,
-0.5202707052230835,
0.3659153878688812,
0.02568652667105198,
-0.6589805483818054,
-0.29763612151145935,
0.5017370581626892,
-0.4235607385635376,
0.3644790053367615,
-0.3005693256855011,
0.010111970826983452,
0.40616267919540405,
0.06919274479150772,
0.3628144860267639,
0.20916303992271423,
0.37355542182922363,
-0.0692455992102623,
-0.05462599918246269,
-0.30585911870002747,
0.24981698393821716,
0.3738730549812317,
-0.5023102164268494,
-0.34396928548812866,
0.462841272354126,
0.7814344763755798,
-0.10366535186767578,
0.32845646142959595,
-0.3211917579174042,
0.4015485942363739,
0.36994603276252747,
-0.34627747535705566,
0.3972530961036682,
-0.5148267149925232,
-0.09382060915231705,
-0.3935717046260834,
0.47808638215065,
-0.31327277421951294,
-0.12599773705005646,
-0.4248501658439636,
0.0730263888835907,
-0.13962243497371674,
-0.37668201327323914,
0.29588839411735535,
0.12317467480897903,
0.3212485611438751,
0.40358999371528625,
-0.045176997780799866,
-0.4614953398704529,
-0.185391366481781,
0.013518369756639004,
-0.3725907802581787,
0.6399879455566406,
0.47673001885414124,
0.18099135160446167,
-0.06353485584259033,
0.048671655356884,
-0.3664289712905884,
-0.2663966417312622,
0.4672464430332184,
0.29740816354751587,
0.6203450560569763,
-0.2705758512020111,
0.10751529037952423,
-0.09705381840467453,
0.25793763995170593,
0.8013765811920166,
-0.24920356273651123,
-0.3039889335632324,
0.24512970447540283,
0.13892503082752228,
-0.5142974257469177,
0.2215462177991867,
0.16364821791648865,
0.19612590968608856,
-0.40739521384239197,
0.10464993119239807,
0.21387609839439392,
-0.4150351881980896,
-0.2789177894592285,
-0.8793044090270996,
-0.33742251992225647,
0.21246452629566193,
-0.15733690559864044,
0.0355735719203949,
0.25645512342453003,
0.1930035650730133,
-0.28868499398231506,
-0.06408955901861191,
0.07554226368665695,
-0.2684573233127594,
0.5248469114303589,
-0.15345850586891174,
-0.07591957598924637,
0.6362756490707397,
-0.6484050750732422,
-0.5585873126983643,
0.025420982390642166,
0.11650707572698593,
-0.18441687524318695,
-0.10051371902227402,
0.13886454701423645,
-0.359210729598999,
-0.5104588866233826,
-0.6355869770050049,
-0.6636881828308105,
0.03693382814526558,
-0.21729949116706848,
0.6769909858703613,
-0.05690062791109085,
0.6637858748435974,
-0.1431778222322464,
-0.5316123962402344,
-0.7421541810035706,
0.3564019501209259,
0.47759532928466797,
-0.3406374454498291,
-0.7042242288589478,
0.2965863347053528,
0.4841567277908325,
0.1621479094028473,
-0.06745648384094238,
0.19712039828300476,
1.1356531381607056,
0.9362736940383911,
-0.132095605134964,
-0.3269311487674713,
-0.0064794886857271194,
0.35164156556129456,
0.044101063162088394,
-0.057268258184194565,
-0.6958544254302979,
-0.10364026576280594,
0.2924414873123169,
0.21717527508735657,
-0.5166513919830322,
-1.0245342254638672,
0.4558481276035309,
-0.3117007911205292,
0.24304595589637756,
0.09644901007413864,
0.49493715167045593,
0.4060998558998108,
-0.3266697824001312,
0.9704621434211731,
-0.24132756888866425,
0.5547993183135986,
-0.3051861822605133,
-0.07167229056358337,
-0.4433738887310028,
-0.19317924976348877,
0.12556849420070648,
-0.3123345673084259,
0.29606643319129944,
-0.15053260326385498,
-0.38039153814315796,
-0.2876974046230316,
0.13379323482513428,
-0.11672338843345642,
-0.2369057983160019,
-0.2479371577501297,
-1.010236382484436,
-0.0014117795508354902,
0.488457053899765,
0.45426249504089355,
0.299618661403656,
0.30498382449150085,
-0.2502650320529938,
-0.4932061731815338,
-0.587982714176178,
0.05867643654346466,
0.9160483479499817,
-0.7952210903167725,
0.08026427030563354,
0.0423879437148571,
0.13473635911941528,
0.22579453885555267,
-0.14026480913162231,
-0.3433041274547577,
0.34994494915008545,
0.22235138714313507,
-0.015924807637929916,
0.0007402758928947151,
-0.6853154301643372,
-0.14766192436218262,
-0.04699678719043732,
0.018902190029621124,
0.4242728650569916,
0.20070286095142365,
0.23280048370361328,
0.07112811505794525,
0.043465569615364075,
0.016322564333677292,
-0.6601372957229614,
0.5594180226325989,
-0.017278272658586502,
-0.03410615772008896,
-0.5665954947471619,
0.2838941812515259,
0.43732231855392456,
0.10229405760765076,
-0.16134817898273468,
0.130150705575943,
-0.40611785650253296,
0.07797267287969589,
-0.24045701324939728,
-0.40589383244514465,
-0.26085177063941956,
0.3061314523220062,
0.4871100187301636,
0.37389811873435974,
-0.5788401961326599,
0.21832171082496643,
0.384941041469574,
0.12131600081920624,
0.4417366087436676,
0.04947395622730255,
-0.3603273034095764,
0.4111102223396301,
0.39377355575561523,
-0.15864194929599762,
-0.10716550052165985,
-0.20859014987945557,
-0.3351720869541168,
-0.1845162957906723,
0.4191913306713104,
-0.5688639283180237,
0.0899229571223259,
0.3206609785556793,
-0.01195485144853592,
0.4392967224121094,
-0.2069479376077652,
0.5406641960144043,
-0.2303997427225113,
-0.37795254588127136,
0.14824321866035461,
0.4460851848125458,
-0.03169994428753853,
-0.3994068503379822,
0.07835293561220169,
0.010299112647771835,
-0.6115869879722595,
0.7026419639587402,
-0.5033470392227173,
-0.5638930797576904,
0.001603911747224629,
-0.02571605145931244,
-0.1422775685787201,
-0.18841396272182465,
-0.3703518509864807,
0.6199555993080139,
-0.23661544919013977,
-0.5545445084571838,
-0.2894868850708008,
-0.10436198860406876,
-0.2564026713371277,
-0.21939779818058014,
0.048620957881212234,
0.13153909146785736,
0.8909031748771667,
-0.9238377213478088,
-0.4257339835166931,
-0.08649138361215591,
-0.08902672678232193,
-0.23491644859313965,
0.15456223487854004,
0.6281028985977173,
0.7563346028327942,
0.3439110815525055,
0.021728282794356346,
0.3148692846298218,
0.17928259074687958,
0.6361434459686279,
-0.40415021777153015,
0.8813469409942627,
-0.1433764398097992,
-0.257901668548584,
-0.43267595767974854,
0.17129595577716827,
0.5802358984947205,
0.5715827941894531,
0.11489687860012054,
0.2735499143600464,
0.5270535349845886,
-0.32121777534484863,
0.4495301842689514,
-0.8297251462936401,
0.1531805694103241,
0.0055356379598379135,
-0.2112477570772171,
-0.6934653520584106,
0.41683539748191833,
-0.11573664098978043,
-0.156253382563591,
-0.1577959954738617,
-0.23314113914966583,
0.34616366028785706,
-0.6461220383644104,
0.24391990900039673,
-0.023982994258403778,
-0.5344144105911255,
-0.1869046688079834,
0.8307747840881348,
-0.4452956020832062,
-0.017630886286497116,
-0.3044244945049286,
0.6433279514312744,
0.31369367241859436,
0.09880251437425613,
-0.04221176356077194,
0.06837612390518188,
-0.3528086245059967,
0.16981065273284912,
0.03992649167776108,
0.5149073004722595,
-0.029509760439395905,
-0.5201913714408875,
-0.6567010879516602,
-0.183918297290802,
-0.03638151288032532,
-0.4154622256755829,
-0.4529043138027191,
0.18457669019699097,
-0.5749409198760986,
-0.8206145167350769,
0.13021089136600494,
-0.24991872906684875,
0.28013598918914795,
0.045981064438819885
] |
Adenoviruses replicate primarily in the host cell nucleus, and it is well established that adenovirus infection affects the structure and function of host cell nucleoli in addition to coding for a number of nucleolar targeted viral proteins. Here we used unbiased proteomics methods, including high throughput mass spectrometry coupled with stable isotope labeling by amino acids in cell culture (SILAC) and traditional two-dimensional gel electrophoresis, to identify quantitative changes in the protein composition of the nucleolus during adenovirus infection. Two-dimensional gel analysis revealed changes in six proteins. By contrast, SILAC-based approaches identified 351 proteins with 24 proteins showing at least a 2-fold change after infection. Of those, four were previously reported to have aberrant localization and/or functional relevance during adenovirus infection. In total, 15 proteins identified as changing in amount by proteomics methods were examined in infected cells using confocal microscopy. Eleven of these proteins showed altered patterns of localization in adenovirus-infected cells. Comparing our data with the effects of actinomycin D on the nucleolar proteome revealed that adenovirus infection apparently specifically targets a relatively small subset of nucleolar antigens at the time point examined. | [
-0.008217046037316322,
0.019828839227557182,
-0.012530166655778885,
0.02188830077648163,
-0.01705765537917614,
-0.0026797952596098185,
0.012185361236333847,
-0.004812199156731367,
-0.017504561692476273,
0.012763334438204765,
-0.007724094204604626,
0.010328589007258415,
-0.03432087227702141,
0.0364447757601738,
0.007993883453309536,
-0.01516730710864067,
-0.02452101930975914,
-0.0032266690395772457,
0.00762056652456522,
-0.021227432414889336,
-0.0013987012207508087,
-0.015108941122889519,
0.012999681755900383,
-0.002527536591514945,
0.015807701274752617,
0.00983903743326664,
0.011436154134571552,
-0.022712450474500656,
-0.012803584337234497,
-0.0161603894084692,
0.0012593693099915981,
0.010254987515509129,
0.0058609903790056705,
-0.012609478086233139,
0.0002510573249310255,
0.017027519643306732,
-0.008022850379347801,
0.032498929649591446,
0.01897718571126461,
-0.0045808241702616215,
0.005175994709134102,
-0.01019350066781044,
0.006430164445191622,
0.010269483551383018,
-0.008457044139504433,
-0.01577465794980526,
-0.0008158650598488748,
-0.008719448000192642,
-0.0015938926953822374,
0.001781851053237915,
-0.013384472578763962,
-0.015927117317914963,
-0.011646341532468796,
0.0358409620821476,
-0.007751185446977615,
0.007897195406258106,
0.024005960673093796,
-0.04037007316946983,
-0.03268582001328468,
0.016361821442842484,
0.0004199226386845112,
0.03228715807199478,
-0.006705844774842262,
-0.005286339670419693,
0.049784041941165924,
-0.06609240174293518,
0.008899969048798084,
-0.009355557151138783,
0.004757601767778397,
-0.006490538362413645,
0.01374639943242073,
0.006728346459567547,
-0.023993048816919327,
0.006845781579613686,
-0.011949671432375908,
-0.002298635896295309,
-0.007065629120916128,
-0.006248730234801769,
-0.005098454654216766,
0.005120879039168358,
-0.004735247232019901,
0.010302424430847168,
0.030244864523410797,
0.006612968165427446,
0.013829445466399193,
0.011541975662112236,
-0.02256450615823269,
-0.0002217974979430437,
0.04122793301939964,
-0.014655649662017822,
0.015006061643362045,
-0.00929590966552496,
-0.011069459840655327,
0.02059316262602806,
-0.0017808577977120876,
-0.017631513997912407,
0.013481983914971352,
-0.009190400131046772,
0.022820759564638138,
-0.047911472618579865,
-0.01186628919094801,
-0.00781180988997221,
0.02409982495009899,
-0.008170302957296371,
-0.007430944591760635,
0.011522063054144382,
0.0027585169300436974,
0.0017596809193491936,
0.03625841066241264,
0.012410780414938927,
0.010813047178089619,
-0.004307678434997797,
-0.0011648435611277819,
0.01243551354855299,
-0.002180185867473483,
0.015800710767507553,
-0.0036059385165572166,
0.032892487943172455,
0.00775896618142724,
0.009068796411156654,
0.0004576267674565315,
-0.017334043979644775,
0.013968215323984623,
0.01300304289907217,
0.002535200212150812,
0.0162003505975008,
-0.0021540303714573383,
-0.007476679049432278,
0.018771786242723465,
0.007704371586441994,
-0.009149219840765,
-0.010965719819068909,
0.026949983090162277,
-0.016312306746840477,
-0.022280123084783554,
0.008456995710730553,
-0.023077361285686493,
-0.01492603775113821,
-0.002590559422969818,
-0.030145151540637016,
0.017627649009227753,
0.006965399254113436,
0.001245737774297595,
0.01622014120221138,
-0.009210457094013691,
-0.00481822295114398,
0.025831744074821472,
-0.0019880791660398245,
0.037961047142744064,
0.004693766124546528,
0.016260070726275444,
0.00034066569060087204,
-0.009461644105613232,
-0.024773072451353073,
0.027730580419301987,
0.006227095145732164,
0.006835063453763723,
-0.023544684052467346,
-0.013626551255583763,
0.008509860374033451,
-0.02376118302345276,
-0.03430730104446411,
0.015880128368735313,
0.011731521226465702,
0.020846810191869736,
-0.01236708089709282,
0.00915452092885971,
-0.010107086971402168,
-0.004291105549782515,
0.008588623255491257,
0.006179932504892349,
0.023383887484669685,
0.01292161364108324,
0.01893794536590576,
-0.005593340843915939,
-0.003861662931740284,
0.05333966389298439,
0.008492964319884777,
-0.024113930761814117,
0.0655147135257721,
0.02394557185471058,
-0.003201799001544714,
-0.03381764143705368,
-0.005999085493385792,
0.015315750613808632,
-0.014670641161501408,
-0.014773059636354446,
-0.0033114689867943525,
-0.007505021058022976,
-0.03617080673575401,
0.00879414938390255,
-0.05556424707174301,
-0.010966631583869457,
-0.018109869211912155,
-0.019997255876660347,
0.0032101301476359367,
-0.0004727886989712715,
-0.0053392015397548676,
-0.0008258656598627567,
0.004597327206283808,
-0.028662366792559624,
-0.00012849457561969757,
0.020317526534199715,
0.008666880428791046,
-0.03468811511993408,
-0.001702660694718361,
-0.02204415202140808,
0.007305339444428682,
0.0017181034199893475,
-0.022311948239803314,
0.018541602417826653,
-0.02806449681520462,
-0.014613121747970581,
-0.0056045143865048885,
0.021002966910600662,
0.01087624579668045,
0.0008674871642142534,
0.0024997172877192497,
-0.030582400038838387,
-0.02146035060286522,
0.007074691355228424,
0.01923837885260582,
-0.020749922841787338,
0.003216166514903307,
0.03364762291312218,
0.013989248313009739,
-0.014452727511525154,
0.015241228975355625,
-0.04238778352737427,
-0.02168380096554756,
-0.017138749361038208,
-0.03502283990383148,
-0.013434350490570068,
-0.010281193070113659,
0.004840397741645575,
0.030123315751552582,
0.01566588319838047,
-0.018818799406290054,
0.009975114837288857,
-0.008023759350180626,
-0.012798670679330826,
-0.0027713750023394823,
0.03444022312760353,
-0.009962118230760098,
-0.03403439372777939,
0.0002047126181423664,
-0.03060236945748329,
-0.014768892899155617,
0.03338091820478439,
-0.02910161390900612,
0.009531361982226372,
-0.0012385293375700712,
0.010935258120298386,
-0.016414131969213486,
0.0009564945939928293,
0.01697656512260437,
-0.0013941244687885046,
-0.024909047409892082,
0.028417129069566727,
-0.008758862502872944,
-0.005242197308689356,
0.0047042109072208405,
-0.01569102331995964,
0.015143183059990406,
0.0074275946244597435,
0.01847444474697113,
0.002329796552658081,
0.0010406461078673601,
-0.004481506533920765,
-0.0009216449689120054,
0.01310429722070694,
-0.0011701902840286493,
0.010158420540392399,
-0.08058325201272964,
-0.012792733497917652,
0.007475721649825573,
0.004018441773951054,
0.01049769390374422,
0.01309613510966301,
0.01878930814564228,
-0.0013308570487424731,
0.001249107881449163,
0.02582542970776558,
0.024877049028873444,
0.01950293593108654,
-0.0010771967936307192,
-0.013809161260724068,
-0.015043312683701515,
0.0005138602573424578,
0.014162855222821236,
-0.01731528714299202,
-0.04794001951813698,
0.010785273276269436,
0.01871573179960251,
-0.001194729469716549,
0.017071308568120003,
0.007178241387009621,
-0.011514142155647278,
0.0330691896378994,
0.014560921117663383,
-0.009860707446932793,
-0.011248525232076645,
0.009739972651004791,
0.012897545471787453,
-0.0088521558791399,
0.03685678541660309,
0.0016582007519900799,
0.003922584466636181,
0.03135833516716957,
-0.013045676052570343,
-0.01991385407745838,
-0.005677422508597374,
0.014033387415111065,
0.018378054723143578,
0.012259485200047493,
0.025109650567173958,
0.015359390527009964,
0.03017793968319893,
-0.0005586335901170969,
0.01824590563774109,
0.017090125009417534,
0.02522609941661358,
0.0052121905609965324,
-0.0035500070080161095,
0.0008459300734102726,
0.028436798602342606,
0.018706537783145905,
-0.013685612007975578,
0.02504008077085018,
-0.01446611899882555,
0.002771626226603985,
-0.016062377020716667,
-0.00928172841668129,
0.0029068675357848406,
-0.019682705402374268,
-0.024746205657720566,
0.03406751900911331,
0.0045114667154848576,
0.0029279659502208233,
0.011902637779712677,
0.01919025182723999,
-0.006547590252012014,
0.024988263845443726,
0.0200092364102602,
0.0014373697340488434,
-0.007877268828451633,
0.007270272821187973,
-0.03750757873058319,
-0.013088390231132507,
-0.0135225560516119,
-0.012249559164047241,
-0.000821482390165329,
-0.009252514690160751,
0.016249651089310646,
-0.0017064176499843597,
-0.0041140359826385975,
-0.022238072007894516,
-0.00289044133387506,
-0.04690529406070709,
0.012073539197444916,
0.02971331775188446,
0.01120147667825222,
-0.024597888812422752,
0.05303805693984032,
0.004377787932753563,
-0.03482963889837265,
0.0035644760355353355,
-0.017413493245840073,
-0.0049056909047067165,
0.00890679657459259,
0.012513972818851471,
0.013543514534831047,
0.010681362822651863,
-0.0017639591824263334,
-0.0010110577568411827,
0.00826194416731596,
-0.009246176108717918,
-0.05251247435808182,
0.01726355403661728,
0.0032389676198363304,
-0.005552489310503006,
0.003945021890103817,
-0.0005959592526778579,
0.019306689500808716,
-0.0038118669763207436,
-0.0082742590457201,
-0.012760254554450512,
0.006955516524612904,
-0.0030102336313575506,
-0.005613255780190229,
-0.028276201337575912,
0.07112935930490494,
0.010864176787436008,
0.006045160815119743,
-0.022067926824092865,
-0.01740271970629692,
-0.012776722200214863,
-0.0044006300158798695,
-0.018846753984689713,
-0.018177466467022896,
0.004730668384581804,
0.015462974086403847,
-0.01848057471215725,
-0.014210402965545654,
-0.01238447055220604,
-0.013132482767105103,
-0.005492127500474453,
0.01648852415382862,
-0.04211905598640442,
-0.002615941921249032,
-0.003488258458673954,
0.0028762200381606817,
0.009241671301424503,
-0.012353786267340183,
0.006671363487839699,
-0.025596844032406807,
-0.008493435569107533,
-0.02595393918454647,
-0.009738275781273842,
-0.016015537083148956,
0.010093078017234802,
0.007838098332285881,
0.016841182485222816,
-0.007246873807162046,
0.008385304361581802,
0.027215778827667236,
-0.021376073360443115,
0.035420533269643784,
0.014527741819620132,
-0.008053062483668327,
-0.027501782402396202,
-0.021397965028882027,
-0.014398995786905289,
-0.021057836711406708,
0.01898234896361828,
-0.020919576287269592,
-0.013469812460243702,
0.002224638592451811,
-0.0038044077809900045,
0.006398996338248253,
-0.005119754932820797,
-0.021045513451099396,
-0.0006618909537792206,
0.0181064922362566,
0.020893285050988197,
0.00802682712674141,
-0.000828343559987843,
-0.0033796364441514015,
-0.013072912581264973,
-0.010421396233141422,
-0.012937434017658234,
-0.031457044184207916,
0.0008153999224305153,
0.007310432381927967,
-0.024598637595772743,
0.01532743126153946,
-0.02309112623333931,
-0.011429384350776672,
-0.010613740421831608,
-0.010385622270405293,
-0.010753008536994457,
0.013172834180295467,
-0.0198002178221941,
-0.013449695892632008,
-0.007778405211865902,
-0.008060949854552746,
-0.02574668824672699,
0.013765052892267704,
-0.025139641016721725,
0.024068579077720642,
0.008499635383486748,
0.027110695838928223,
0.017382286489009857,
-0.0012257159687578678,
0.03480443358421326,
0.009927259758114815,
-0.023028966039419174,
-0.04100847244262695,
-0.07415544986724854,
0.03084481693804264,
-0.02576253190636635,
-0.008268702775239944,
0.017272014170885086,
0.002892801770940423,
-0.016188953071832657,
0.0018996952567249537,
-0.010859103873372078,
-0.013806595467031002,
-0.013125230558216572,
0.015808995813131332,
0.0095236636698246,
0.015795491635799408,
0.01480980683118105,
-0.004687463864684105,
-0.026678232476115227,
-0.010996931232511997,
-0.00863175094127655,
0.006468644831329584,
0.010875573381781578,
0.025917652994394302,
-0.03553399071097374,
0.01134003046900034,
-0.007936516776680946,
-0.08036910742521286,
-0.010243227705359459,
0.004030024167150259,
-0.015914563089609146,
0.015351638197898865,
-0.00007465947419404984,
-0.02293200045824051,
-0.016179487109184265,
0.012931862846016884,
-0.021858450025320053,
0.01377628743648529,
-0.021222315728664398,
0.00852924957871437,
-0.02858300879597664,
-0.006815062835812569,
-0.0026917243376374245,
-0.009592709131538868,
0.014268322847783566,
-0.00031635304912924767,
0.025530852377414703,
-0.0064753396436572075,
0.03694358468055725,
-0.013890726491808891,
0.001085328753106296,
-0.013598989695310593,
-0.01143476739525795,
0.030557941645383835,
0.009279345162212849,
0.010642709210515022,
0.010983720421791077,
0.0010968863498419523,
0.000698162242770195,
-0.0060935537330806255,
-0.04321318119764328,
0.024538207799196243,
-0.007536540739238262,
0.0029311347752809525,
0.02070755697786808,
0.01979506015777588,
-0.0018138522282242775,
-0.012725481763482094,
-0.003539951052516699,
0.031880736351013184,
0.015760144218802452,
0.00638345954939723,
-0.008196903392672539,
0.006197155918926001,
-0.005012909881770611,
0.02177322842180729,
-0.0022717718966305256,
0.0004029263218399137,
-0.016643088310956955,
0.020938899368047714,
0.02156412973999977,
0.0004465451929718256,
0.03125583007931709,
-0.0034894209820777178,
0.022353552281856537,
-0.010743379592895508,
0.007026976905763149,
-0.008971516974270344,
-0.020029647275805473,
0.0035963128320872784,
0.07018400728702545,
-0.02000504545867443,
-0.009797303006052971,
-0.02817915380001068,
-0.013444147072732449,
0.003726040478795767,
-0.005383901763707399,
0.02420637384057045,
0.018015028908848763,
-0.029654033482074738,
-0.008953966200351715,
0.003353482112288475,
0.0031119929626584053,
0.011113259941339493,
0.015003204345703125,
0.003944798372685909,
-0.017290078103542328,
0.005323298275470734,
-0.01423211582005024,
-0.008265320211648941,
-0.018790043890476227,
-0.022187434136867523,
-0.03006189875304699,
-0.008070997893810272,
0.015889368951320648,
-0.01835458353161812,
-0.003305967664346099,
0.0025861156173050404,
-0.016543783247470856,
0.015941448509693146,
-0.027164489030838013,
-0.02356204017996788,
0.0068902187049388885,
0.027249688282608986,
0.020203325897455215,
0.007970619946718216,
-0.019086763262748718,
-0.0035817499738186598,
-0.00820231344550848,
0.012333311140537262,
0.02397381141781807,
-0.016856977716088295,
-0.005888313055038452,
-0.0290756244212389,
0.016186635941267014,
-0.017032980918884277,
0.012850338593125343,
-0.02624283730983734,
0.019382162019610405,
0.006524127908051014,
0.01834622398018837,
0.016599243506789207,
-0.005029939115047455,
-0.012279120273888111,
0.008398748002946377,
0.0099348034709692,
0.014522063545882702,
0.021239938214421272,
0.008991559967398643,
-0.037763841450214386,
0.019116897135972977,
-0.015357594937086105,
-0.047471437603235245,
-0.028655584901571274,
0.010833367705345154,
-0.009278664365410805,
0.010112708434462547,
-0.01770176738500595,
-0.006956175900995731,
0.013908391818404198,
-0.008655305951833725,
0.004102157428860664,
0.010382140055298805,
-0.005713926162570715,
0.035424649715423584,
-0.014699283055961132,
0.04939383268356323,
0.019263889640569687,
0.010500334203243256,
-0.0011252239346504211,
-0.007260389160364866,
-0.016432687640190125,
-0.014853056520223618,
0.015605100430548191,
-0.016581449657678604,
-0.0012103337794542313,
-0.037637315690517426,
-0.007912050932645798,
-0.011295763775706291,
0.004496273584663868,
0.01841944456100464,
0.013378232717514038,
0.008294356986880302,
0.016595590859651566,
0.006757346913218498,
0.03576687350869179,
0.002796750981360674,
0.007041675038635731,
0.012236980721354485,
-0.0017501753754913807,
0.004076503217220306,
-0.0003129914402961731,
-0.018360264599323273,
-0.010358319617807865,
-0.03650929033756256,
-0.010265170596539974,
0.027918528765439987,
0.004832116886973381,
-0.0020544263534247875,
0.01291635911911726,
-0.0008017513900995255,
0.01783602312207222,
0.029082436114549637,
0.02478044107556343,
-0.011940091848373413,
0.02546456828713417,
-0.026809999719262123,
-0.008088916540145874,
-0.00214272178709507,
-0.016309348866343498,
-0.036363426595926285,
0.006756162736564875,
0.015303400345146656,
-0.0032247365452349186,
0.009051534347236156,
-0.026654919609427452,
-0.009597381576895714,
0.0148059893399477,
0.006110725924372673,
-0.00174229359254241,
0.013049673289060593,
0.03332064300775528,
0.0010118093341588974,
-0.016729360446333885,
0.007802034728229046,
0.003979790955781937,
0.009106485173106194,
0.020836643874645233,
-0.007907113060355186,
-0.02249748259782791,
-0.018026895821094513,
-0.033049825578927994,
-0.0030159782618284225,
0.00361074972897768,
0.011168070137500763,
-0.000748850405216217,
0.012576496228575706,
-0.020320992916822433,
0.01449662446975708,
-0.009953528642654419,
0.01907167211174965,
0.015105800703167915,
0.008678841404616833,
-0.009277841076254845,
-0.005239248275756836,
0.01882530376315117,
-0.0007011481793597341,
-0.02727564424276352,
-0.009405645541846752,
0.00246347370557487,
0.030185816809535027,
-0.006614158861339092,
0.008898706175386906,
0.021713867783546448,
-0.023176707327365875,
0.001079921843484044,
0.002949996618553996,
0.033174190670251846,
-0.0074648004956543446,
0.029951922595500946,
0.029696259647607803,
-0.003207781119272113,
0.015212327241897583,
0.02876327559351921,
-0.028955064713954926,
-0.013804311864078045,
-0.02387913130223751,
0.007746795192360878,
-0.01749630831182003,
-0.00749819353222847,
0.006042844615876675,
-0.008964765816926956,
-0.006758834235370159,
-0.007167937699705362,
-0.013314921408891678,
0.006952021270990372,
-0.01727183163166046,
0.024067005142569542,
-0.0003193141892552376,
-0.005866792984306812,
-0.03922579064965248,
0.014245865866541862,
-0.0002278713509440422,
-0.002289003459736705,
-0.019592104479670525,
-0.0026604742743074894,
-0.012655275873839855,
-0.019211288541555405,
0.003944015596061945,
0.028151817619800568,
0.009581664577126503,
0.0030488143675029278
] | [
0.13522404432296753,
0.21822352707386017,
-0.3748963475227356,
-0.2503657937049866,
0.15691296756267548,
0.012118351645767689,
0.41738876700401306,
0.09761109948158264,
-0.04804891720414162,
-0.7398942112922668,
0.2431105226278305,
-0.032636430114507675,
-0.8647753000259399,
0.569752037525177,
0.08216902613639832,
0.9187584519386292,
0.014632882550358772,
0.30307385325431824,
-0.536404013633728,
-0.12452265620231628,
-0.18520496785640717,
-0.3098636865615845,
0.4086008071899414,
0.07244399935007095,
0.4276321232318878,
-0.5925942063331604,
0.7218733429908752,
0.0012861262075603008,
0.5819727778434753,
-0.5066384673118591,
-0.09977864474058151,
0.45829224586486816,
-0.5066062808036804,
-0.04693913459777832,
-0.3561912477016449,
-0.3224447965621948,
-1.0267976522445679,
0.005321165081113577,
0.30660441517829895,
-0.2545945644378662,
-0.44773784279823303,
-0.40652772784233093,
-0.6147006750106812,
0.3153863847255707,
-0.13582110404968262,
-0.774749219417572,
-1.1521419286727905,
1.049946665763855,
-0.47235190868377686,
-0.21953484416007996,
0.24014323949813843,
0.16223692893981934,
0.4700169563293457,
-0.04855214059352875,
0.01978188008069992,
0.062296487390995026,
-0.5419302582740784,
-0.18831969797611237,
0.6906182169914246,
-0.30644690990448,
0.3678293526172638,
-0.19141167402267456,
-0.14450258016586304,
0.4034743010997772,
0.006078535690903664,
0.7589157819747925,
0.15456195175647736,
0.06607373803853989,
-0.31366318464279175,
-0.12419374287128448,
-0.30137667059898376,
-0.5275009274482727,
-0.117289699614048,
0.17317278683185577,
0.18451081216335297,
0.21431608498096466,
-0.3191051781177521,
-0.5472579598426819,
0.18486562371253967,
0.3024163842201233,
-0.2260165810585022,
0.23782183229923248,
0.025426756590604782,
-0.2578597068786621,
0.5245828628540039,
-0.21415649354457855,
-0.4610689878463745,
0.8288938403129578,
-0.24503661692142487,
-0.012599041685461998,
0.36383435130119324,
0.11493789404630661,
0.7453317642211914,
0.32286056876182556,
0.1339009553194046,
0.009036033414304256,
-0.392799973487854,
0.4318530857563019,
0.08859021961688995,
0.35719990730285645,
-0.11529568582773209,
0.30380842089653015,
-0.22514231503009796,
-0.36422526836395264,
-0.441699355840683,
0.07361463457345963,
-0.14924947917461395,
-0.5734694004058838,
-0.7033644914627075,
0.13128778338432312,
-0.374693900346756,
-0.27079853415489197,
-0.5035093426704407,
-0.18615923821926117,
-0.10635648667812347,
-0.20088675618171692,
0.5814547538757324,
-0.666954517364502,
-0.3221568465232849,
-0.20218898355960846,
-0.6501046419143677,
0.9498241543769836,
-0.18698249757289886,
0.4569714367389679,
-0.33079519867897034,
-0.42554983496665955,
-0.27270567417144775,
-0.014772193506360054,
-0.5750318169593811,
0.5539579391479492,
0.39283260703086853,
0.8108466267585754,
-0.3222971558570862,
0.32184305787086487,
-0.004751306492835283,
-0.10862209647893906,
-0.5277063846588135,
0.6337901949882507,
0.6871598958969116,
-0.5200695395469666,
-0.191520556807518,
-0.6456286907196045,
-0.5928762555122375,
0.22429457306861877,
-0.2669249475002289,
-0.5138149261474609,
-0.53374844789505,
-0.013971559703350067,
0.09423725306987762,
-0.4317806363105774,
-0.2505395710468292,
-0.7191932201385498,
-0.5967229604721069,
0.10057606548070908,
-0.25429877638816833,
0.03361288458108902,
0.12531620264053345,
0.1546029895544052,
-0.05746165290474892,
0.2969255745410919,
0.018278028815984726,
-0.17128297686576843,
-0.32646188139915466,
-0.11223822832107544,
0.23177140951156616,
-0.054862912744283676,
0.7373560667037964,
0.5694029331207275,
0.4622551202774048,
-0.3407447636127472,
-0.3647845983505249,
-0.3285605013370514,
0.29661622643470764,
-0.5747774839401245,
-0.23699156939983368,
-0.16972315311431885,
0.29648202657699585,
-0.19810320436954498,
0.4423011541366577,
0.03216978907585144,
-0.4812697470188141,
-0.1944565773010254,
0.033523958176374435,
-0.0944521501660347,
0.2684193253517151,
0.047713883221149445,
-0.3119259178638458,
-0.050984807312488556,
-0.261392742395401,
-0.0667496770620346,
-0.19513006508350372,
-0.13543500006198883,
0.4095371961593628,
0.0638861283659935,
0.9763755202293396,
-0.3347916901111603,
-0.3210539221763611,
1.5712804794311523,
0.6428174376487732,
-0.22964411973953247,
-0.2422211617231369,
-0.0348377600312233,
0.10390574485063553,
-0.3328438103199005,
-0.42053142189979553,
-0.11071746796369553,
0.02651590295135975,
-0.6285690069198608,
0.09713967889547348,
-0.016672546043992043,
0.24749666452407837,
-0.3966315686702728,
0.15782088041305542,
-0.5216862559318542,
0.41920343041419983,
0.08679022639989853,
-0.29096120595932007,
0.09751364588737488,
-0.5608950257301331,
0.06099780648946762,
0.6429492831230164,
-0.8227443099021912,
0.7236842513084412,
0.9204475283622742,
-0.5705790519714355,
0.4722993075847626,
0.20987828075885773,
0.21372337639331818,
1.3357439041137695,
-0.7462872862815857,
0.38073378801345825,
-0.8103156685829163,
0.5317015647888184,
-0.5465397834777832,
-0.34735503792762756,
0.25709742307662964,
-0.2947920560836792,
-0.0012989980168640614,
-0.29134517908096313,
-0.0030846172012388706,
0.6070221066474915,
0.8128332495689392,
-0.9837843775749207,
-0.25543805956840515,
0.2828610837459564,
-0.4995032846927643,
-0.14154450595378876,
-0.051256213337183,
-0.6799823641777039,
0.3155168294906616,
0.037401825189590454,
0.41452670097351074,
0.4931052029132843,
-0.5118123292922974,
0.7448582649230957,
0.03354136273264885,
0.09256080538034439,
-0.07850933074951172,
0.4236191511154175,
-0.4129854440689087,
-0.32513150572776794,
-0.02810118906199932,
-0.04630538448691368,
0.2647649645805359,
-0.27394208312034607,
-0.6436368227005005,
-0.2773370146751404,
-0.287595272064209,
0.7611504197120667,
0.5772594213485718,
1.324871301651001,
0.36602890491485596,
-0.7885017395019531,
0.08618590235710144,
0.4826180934906006,
-0.622471809387207,
0.5138967633247375,
0.55536949634552,
-0.22438514232635498,
-0.18851402401924133,
-0.2143087089061737,
-0.15431919693946838,
0.6606310606002808,
-0.6832467913627625,
-0.3061095178127289,
-0.30961865186691284,
-0.02766351029276848,
-0.25536319613456726,
-0.7154294848442078,
-0.10113361477851868,
-0.5171157121658325,
0.4121306240558624,
-0.5274958610534668,
0.47090283036231995,
-0.060948509722948074,
0.47765424847602844,
-0.09623336791992188,
0.37928876280784607,
0.754715621471405,
-0.5047866106033325,
-0.2158704549074173,
0.17032335698604584,
-0.7073118090629578,
-0.005006312392652035,
-0.27529555559158325,
0.3650837242603302,
-0.3424757122993469,
-0.012913364917039871,
-5.4947052001953125,
0.041215717792510986,
0.03659249097108841,
0.020657949149608612,
0.241843119263649,
0.06988321989774704,
1.2124520540237427,
-0.08603594452142715,
0.5030112862586975,
-0.09884341806173325,
0.5635300278663635,
0.20316539704799652,
-0.05881885811686516,
-0.39359772205352783,
-0.11636379361152649,
0.1568681299686432,
0.3767683506011963,
0.18806636333465576,
0.5153553485870361,
0.020039603114128113,
0.046966295689344406,
-0.26000142097473145,
-0.3705749809741974,
0.20390082895755768,
-0.22336670756340027,
0.020518425852060318,
-0.6246135234832764,
0.05249748378992081,
-0.10148710012435913,
0.43646231293678284,
-0.4499970078468323,
-1.0319498777389526,
-0.19277186691761017,
-0.11066319793462753,
0.0017669025110080838,
0.02226446196436882,
-0.005981565453112125,
-0.4617420434951782,
-0.015336740761995316,
-0.1374114453792572,
0.1506047248840332,
0.2629263997077942,
-0.07447773963212967,
-0.2914777398109436,
-0.1888556033372879,
-0.3280491530895233,
0.11438159644603729,
0.10067993402481079,
-0.654792070388794,
1.1283807754516602,
-0.05546028912067413,
-0.13958479464054108,
0.5590826869010925,
0.8290007710456848,
0.7982544302940369,
-0.12020085752010345,
0.3435651361942291,
-0.13477779924869537,
-0.21103112399578094,
-0.09881816804409027,
-0.27593719959259033,
-0.008361725136637688,
-0.3470589518547058,
-0.5437831878662109,
0.26029112935066223,
-0.11333301663398743,
-0.5610799789428711,
-0.3102179765701294,
0.4316257834434509,
0.04467007890343666,
-0.6058760285377502,
0.1089605763554573,
-0.19080279767513275,
-0.7127728462219238,
0.4524066746234894,
-0.23046875,
0.10132276266813278,
-0.3761245608329773,
0.10972705483436584,
-0.40305042266845703,
-0.5255278944969177,
-0.23650570213794708,
-0.2938010096549988,
-0.2072271853685379,
0.14167483150959015,
-0.7586774826049805,
-0.21960251033306122,
0.04737580940127373,
-0.22255447506904602,
-0.31081074476242065,
0.41194847226142883,
-0.10199578106403351,
0.1459031105041504,
0.24372664093971252,
0.37364792823791504,
0.30928415060043335,
0.19592398405075073,
0.5434216260910034,
1.0249810218811035,
0.026734625920653343,
1.2665398120880127,
-0.6477096676826477,
-0.3979887068271637,
-0.7426891326904297,
-0.12367703765630722,
0.23297728598117828,
-0.49528658390045166,
0.00019685481674969196,
0.7119929790496826,
-0.8673467040061951,
0.1811399757862091,
0.2967675030231476,
-0.5010354518890381,
-0.04361122474074364,
0.684683084487915,
-0.692590594291687,
0.537550151348114,
0.6753278970718384,
0.6679652333259583,
0.0006519826711155474,
0.29087066650390625,
0.432428240776062,
-0.6426085829734802,
0.41682514548301697,
0.2212638556957245,
-0.23730596899986267,
0.26241767406463623,
0.07915040850639343,
-0.24415023624897003,
-0.4561101198196411,
0.22921818494796753,
0.22046679258346558,
-0.2398618459701538,
0.06563536822795868,
0.32720762491226196,
-0.37108075618743896,
-0.2146349847316742,
-0.39217910170555115,
-0.12584570050239563,
-0.06537522375583649,
-0.012154708616435528,
-0.35783761739730835,
0.10395881533622742,
0.26242595911026,
0.43535277247428894,
0.025135772302746773,
0.031795911490917206,
0.07402535527944565,
-0.2755114436149597,
-0.16619069874286652,
-0.0823240578174591,
-0.021734731271862984,
-0.096952885389328,
0.15380966663360596,
-0.30032455921173096,
0.6009632349014282,
1.047690987586975,
-0.17683179676532745,
0.46170589327812195,
-0.7469973564147949,
0.15381066501140594,
0.20049646496772766,
-0.7784948348999023,
0.4481576085090637,
-0.4698003828525543,
-0.09739790856838226,
0.00038213119842112064,
-0.18036851286888123,
-0.022784650325775146,
0.4573182165622711,
-0.8942825794219971,
-0.06614614278078079,
-0.23288151621818542,
-0.15631967782974243,
0.00018176336016040295,
-0.343901664018631,
-0.5736366510391235,
0.19788318872451782,
-0.12567012012004852,
0.0907498374581337,
0.10419062525033951,
-0.45671844482421875,
-0.43479201197624207,
0.47154223918914795,
0.18541747331619263,
0.4015720784664154,
-0.3378545641899109,
-0.3972861170768738,
-0.7556010484695435,
-0.5057898163795471,
0.06452405452728271,
0.3178616166114807,
-0.020362943410873413,
-0.341220498085022,
0.16264879703521729,
0.1398799866437912,
0.13593685626983643,
0.30484363436698914,
-0.12779012322425842,
-0.5097032785415649,
0.4996052086353302,
0.41589033603668213,
-0.7393123507499695,
0.8090790510177612,
0.18085022270679474,
0.28935670852661133,
0.10527154058218002,
-0.40117335319519043,
0.2426822930574417,
-0.04350805655121803,
-0.3802053928375244,
-0.24354949593544006,
0.025803348049521446,
0.8634957075119019,
-0.11782966554164886,
0.4766848087310791,
-0.12496685236692429,
-0.5143477916717529,
0.6483466625213623,
0.4068347215652466,
-0.15564067661762238,
0.12307710945606232,
0.17456670105457306,
0.06967049837112427,
-0.1012006551027298,
0.7384001016616821,
0.46231400966644287,
-0.7157496809959412,
-0.26351967453956604,
0.48642390966415405,
0.39692214131355286,
-0.5991840958595276,
0.15852905809879303,
0.05964982882142067,
-0.6895011067390442,
-0.4781748056411743,
-0.23404476046562195,
-0.3289914131164551,
-0.04970163106918335,
0.6895793676376343,
0.6041810512542725,
0.45840340852737427,
-0.49113550782203674,
0.1609257161617279,
-0.026271870359778404,
0.3391333520412445,
0.8086823225021362,
-0.3138439953327179,
-0.7107003331184387,
0.39405184984207153,
-0.08137895166873932,
0.043712470680475235,
-0.34321486949920654,
0.6823663711547852,
0.8202741146087646,
0.05482352524995804,
-0.22436778247356415,
-0.24779823422431946,
-0.3131067454814911,
-0.2718033194541931,
0.12653549015522003,
-0.14475546777248383,
-0.14248283207416534,
0.017943132668733597,
-0.1004277840256691,
-0.1378202885389328,
-0.5567508339881897,
-0.37742939591407776,
0.43667101860046387,
0.08902031928300858,
-0.38927021622657776,
0.09578997641801834,
1.076786994934082,
0.3885379433631897,
-0.32077714800834656,
0.6196918487548828,
0.057299673557281494,
0.2274409383535385,
-0.23264001309871674,
0.7433825135231018,
-0.5102090835571289,
-0.3275049924850464,
0.5556910037994385,
-0.19568483531475067,
0.5424984097480774,
-0.4782450497150421,
-0.09829560667276382,
-0.31934303045272827,
0.03114888444542885,
-0.623262882232666,
-0.12431123107671738,
-0.22747497260570526,
-0.7715030908584595,
-0.106109619140625,
0.2237294614315033,
0.5514897704124451,
0.14434672892093658,
0.30128616094589233,
-0.1929543912410736,
0.19572855532169342,
-0.9793493747711182,
0.9617738127708435,
0.58673095703125,
-0.35242778062820435,
0.2978009581565857,
0.060731519013643265,
0.11526448279619217,
0.6447396278381348,
-0.12042034417390823,
-0.34994104504585266,
-0.1776428520679474,
-0.015120122581720352,
0.5053039789199829,
0.03402296081185341,
-0.6070936322212219,
0.16769084334373474,
0.18705147504806519,
-0.380386084318161,
0.2748952805995941,
0.059540700167417526,
0.21166440844535828,
0.7098012566566467,
0.00203119614161551,
-0.3758540451526642,
-0.3559044599533081,
0.8550077080726624,
-0.184719517827034,
0.09111706912517548,
-0.17564399540424347,
0.5256934762001038,
0.9363781809806824,
-0.06106537580490112,
-0.36857956647872925,
0.5485155582427979,
0.2972593903541565,
0.26208600401878357,
0.29122865200042725,
-0.37357157468795776,
-0.13431482017040253,
0.5762871503829956,
0.5377808809280396,
0.1332738697528839,
-0.09390263259410858,
0.01922057755291462,
-0.10896879434585571,
0.3300633132457733,
-0.012643269263207912,
-0.05342091992497444,
0.27945977449417114,
0.07820764929056168,
0.5174967050552368,
-0.5498813390731812,
0.0765630379319191,
0.5038447976112366,
-0.2365439534187317,
-0.010853147134184837,
0.8967331051826477,
-0.25889378786087036,
-0.7526885271072388,
0.014968851581215858,
-0.3702411949634552,
0.17257662117481232,
0.2384866178035736,
0.7773301005363464,
0.07073768973350525,
0.10292087495326996,
0.6314496397972107,
-0.2539687752723694,
0.30579903721809387,
-0.18542657792568207,
0.5018807053565979,
-0.0056305802427232265,
-0.4137432277202606,
0.25552883744239807,
0.4416474401950836,
-0.08413107693195343,
0.12239565700292587,
0.22261734306812286,
-0.263450562953949,
0.40796762704849243,
-0.14868514239788055,
-0.5141385197639465,
-0.05707317590713501,
-0.4471012353897095,
-0.23383376002311707,
-0.13429094851016998,
-0.31282490491867065,
-0.09113603085279465,
0.23154492676258087,
-0.0380229614675045,
0.5459684729576111,
-0.7118350267410278,
0.2598741352558136,
-0.06513448804616928,
-0.026131782680749893,
0.3224744200706482,
-0.07849106937646866,
0.23239605128765106,
-0.07698898017406464,
0.2148454338312149,
0.06817463785409927,
0.47376906871795654,
-0.6643387675285339,
0.3218485116958618,
-0.8697597980499268,
0.7824631333351135,
0.19123443961143494,
-0.20149627327919006,
-0.8903870582580566,
0.2771948575973511,
1.410285472869873,
0.7146791815757751,
-0.20001456141471863,
-0.007553053088486195,
-0.1477414220571518,
0.4816536009311676,
0.24715371429920197,
-0.6840653419494629,
-0.06036553159356117,
-0.6268051266670227,
0.10134443640708923,
-0.7607493996620178,
0.336667537689209,
0.03396274521946907,
-0.21420946717262268,
-0.13425715267658234,
0.5667214393615723,
0.513306736946106,
-0.7384254336357117,
0.41586068272590637,
-0.1569441556930542,
0.1751636266708374,
-0.6054258942604065,
0.09863848239183426,
-0.6132094860076904,
0.07542793452739716,
-0.06757329404354095,
0.638018786907196,
0.4243123531341553,
0.0413094088435173,
0.8720831274986267,
-0.24003519117832184,
-0.4046119153499603,
0.09356169402599335,
-0.13356181979179382,
-0.01730688288807869,
-0.22337378561496735,
-0.04812178015708923,
-0.4435592293739319,
0.1805931180715561,
0.051120080053806305,
-0.5083166360855103,
-0.20478497445583344,
0.2934528887271881,
-0.635866105556488,
-0.12976820766925812,
-0.007998904213309288,
-0.23342157900333405,
0.06954947113990784,
0.3053005337715149
] |
BACKGROUND: The isolation of human monoclonal antibodies (mAbs) that neutralize a broad spectrum of primary HIV-1 isolates and the characterization of the human neutralizing antibody B cell response to HIV-1 infection are important goals that are central to the design of an effective antibody-based vaccine. METHODS AND FINDINGS: We immortalized IgG(+) memory B cells from individuals infected with diverse clades of HIV-1 and selected on the basis of plasma neutralization profiles that were cross-clade and relatively potent. Culture supernatants were screened using various recombinant forms of the envelope glycoproteins (Env) in multiple parallel assays. We isolated 58 mAbs that were mapped to different Env surfaces, most of which showed neutralizing activity. One mAb in particular (HJ16) specific for a novel epitope proximal to the CD4 binding site on gp120 selectively neutralized a multi-clade panel of Tier-2 HIV-1 pseudoviruses, and demonstrated reactivity that was comparable in breadth, but distinct in neutralization specificity, to that of the other CD4 binding site-specific neutralizing mAb b12. A second mAb (HGN194) bound a conserved epitope in the V3 crown and neutralized all Tier-1 and a proportion of Tier-2 pseudoviruses tested, irrespective of clade. A third mAb (HK20) with broad neutralizing activity, particularly as a Fab fragment, recognized a highly conserved epitope in the HR-1 region of gp41, but showed striking assay-dependent selectivity in its activity. CONCLUSIONS: This study reveals that by using appropriate screening methods, a large proportion of memory B cells can be isolated that produce mAbs with HIV-1 neutralizing activity. Three of these mAbs show unusual breadth of neutralization and therefore add to the current panel of HIV-1 neutralizing antibodies with potential for passive protection and template-based vaccine design. | [
0.00014121457934379578,
0.009785846807062626,
-0.01419488713145256,
0.009863038547337055,
-0.0033936696127057076,
0.004011572804301977,
0.009922211989760399,
0.011122629977762699,
-0.016699977219104767,
-0.0032666902989149094,
-0.006996526848524809,
0.0206616073846817,
0.0046603744849562645,
0.039697930216789246,
-0.03106525167822838,
-0.018810689449310303,
-0.037460215389728546,
-0.0045641507022082806,
0.006379656493663788,
-0.003191928379237652,
0.016984594985842705,
-0.004971565678715706,
0.010832386091351509,
-0.04884124547243118,
0.010822519659996033,
0.03825623542070389,
0.0025648511946201324,
-0.004136315546929836,
0.00400178786367178,
-0.017778407782316208,
-0.01526631973683834,
-0.010740346275269985,
0.029222730547189713,
-0.0367928147315979,
-0.00980109442025423,
-0.003107646945863962,
-0.0016225608997046947,
0.025427915155887604,
-0.015212407335639,
-0.002829530742019415,
0.005022923927754164,
-0.014917325228452682,
0.005075850524008274,
-0.01922019012272358,
-0.008616410195827484,
-0.02280479297041893,
-0.00098246184643358,
0.0061278254725039005,
0.004155411384999752,
0.0039315978065133095,
-0.00583620136603713,
-0.013547694310545921,
-0.011875011026859283,
-0.03069714456796646,
-0.006757830269634724,
0.0048882802948355675,
0.019068405032157898,
-0.010896123945713043,
0.008781475014984608,
0.010105466470122337,
0.022172093391418457,
-0.0022877189330756664,
0.014926305040717125,
-0.03415144234895706,
-0.012686904519796371,
-0.06663662195205688,
0.009152902290225029,
0.03786756843328476,
0.004046897403895855,
0.020868394523859024,
0.012640278786420822,
0.015491420403122902,
0.01392848789691925,
-0.0013366308994591236,
-0.04022779315710068,
-0.009343782439827919,
-0.009867647662758827,
0.050831496715545654,
-0.0022667618468403816,
0.0248496625572443,
0.01449679583311081,
0.014545593410730362,
0.03004525974392891,
0.034941837191581726,
-0.001843736506998539,
-0.007658830378204584,
-0.03169065713882446,
0.015079457312822342,
0.02283392660319805,
-0.028136789798736572,
0.00176288653165102,
-0.03605546057224274,
-0.028683364391326904,
-0.003042622935026884,
-0.007025259546935558,
0.00430556945502758,
-0.011748169548809528,
-0.021402548998594284,
0.0157315693795681,
-0.005221674218773842,
-0.01631753519177437,
-0.012429997324943542,
0.012167297303676605,
0.007775097154080868,
-0.009950201027095318,
0.005481252912431955,
0.004246012307703495,
-0.0034016002900898457,
0.0015376843512058258,
0.006888125091791153,
-0.0004456634633243084,
-0.0009738593362271786,
0.000583612360060215,
0.03723268583416939,
-0.019006697461009026,
0.019370071589946747,
-0.0054088192991912365,
0.00589419063180685,
0.020635053515434265,
0.029374517500400543,
-0.009250037372112274,
-0.011771658435463905,
0.006596097256988287,
-0.030638832598924637,
0.002950694877654314,
-0.010542578995227814,
-0.011020021513104439,
0.015571334399282932,
-0.0012393216602504253,
0.013415997847914696,
-0.011623767204582691,
0.019575607031583786,
-0.007847157306969166,
-0.023203721269965172,
0.0024346124846488237,
0.0123044578358531,
0.00531519902870059,
0.0019734923262149096,
-0.0004835862200707197,
-0.021809065714478493,
-0.016927704215049744,
0.010351961478590965,
-0.0028658020310103893,
0.02313489466905594,
-0.019026054069399834,
0.014463473111391068,
-0.02155000902712345,
-0.00957467220723629,
0.015505103394389153,
-0.03956020995974541,
0.016836823895573616,
-0.020917190238833427,
-0.03056866116821766,
-0.01817149855196476,
0.0008763964287936687,
0.016743965446949005,
0.009257104247808456,
-0.016863210126757622,
-0.02938537672162056,
0.01802268996834755,
0.02522341161966324,
0.012812133878469467,
-0.0061223478987813,
0.010405825451016426,
0.028870584443211555,
0.00003837607800960541,
0.01309396792203188,
-0.00570074375718832,
-0.005900006741285324,
0.007814552634954453,
-0.012770215049386024,
0.0450490340590477,
0.0002130214124917984,
0.006879223510622978,
0.011557506397366524,
0.0012076692655682564,
0.007662429474294186,
0.007770664989948273,
-0.013913487084209919,
0.06560494005680084,
0.006597650237381458,
0.031132478266954422,
-0.023972060531377792,
0.04426173120737076,
0.015976209193468094,
-0.0002437883522361517,
0.009593775495886803,
-0.014743228442966938,
-0.021346040070056915,
0.02260667458176613,
0.01602690853178501,
-0.04055549576878548,
-0.010314369574189186,
0.0005719475448131561,
0.01368032954633236,
0.0028872149996459484,
0.02281450293958187,
0.0137217678129673,
0.0026396012399345636,
-0.022287029772996902,
0.0081687793135643,
0.00150700518861413,
0.056251443922519684,
-0.0034503506030887365,
-0.05418431758880615,
0.01207677461206913,
0.019747205078601837,
-0.014755750074982643,
-0.017762530595064163,
-0.014077774249017239,
0.04491562396287918,
0.004338555037975311,
-0.0018206536769866943,
-0.010034683160483837,
-0.0012589138932526112,
-0.021409638226032257,
0.008308672346174717,
-0.015523791313171387,
-0.01363365724682808,
-0.01898958347737789,
-0.005743176210671663,
0.021315518766641617,
-0.04449716582894325,
0.027330555021762848,
0.009430387057363987,
0.008909802883863449,
0.018713511526584625,
0.012639052234590054,
0.011063624173402786,
0.02619026228785515,
-0.02230042964220047,
0.0049781338311731815,
-0.013181399554014206,
-0.022000592201948166,
0.023001806810498238,
-0.01878509297966957,
0.011910065077245235,
-0.011872013099491596,
0.017146240919828415,
-0.012895312160253525,
-0.0236065611243248,
-0.006457452196627855,
-0.02083688974380493,
-0.02573714591562748,
0.03211076185107231,
0.00806114636361599,
-0.0007730145007371902,
-0.007497045677155256,
-0.023743653669953346,
-0.019495386630296707,
0.009019365534186363,
-0.006208701059222221,
0.015231369063258171,
-0.04958205297589302,
-0.0010287113254889846,
-0.035961318761110306,
0.01347699947655201,
0.011299379169940948,
0.02379603125154972,
0.0061016809195280075,
-0.0012613239232450724,
0.004291096702218056,
-0.019495142623782158,
-0.017634611576795578,
0.02780763804912567,
0.03407750651240349,
0.0012451985385268927,
0.025344889611005783,
-0.025219470262527466,
-0.04147067293524742,
0.012486998923122883,
-0.009602006524801254,
0.013818129897117615,
-0.08049871027469635,
-0.021239064633846283,
-0.037584591656923294,
-0.011777726002037525,
0.010791036300361156,
-0.009948290884494781,
-0.009432870894670486,
0.01720004342496395,
-0.0180012509226799,
0.009686725214123726,
0.010945677757263184,
0.0240996852517128,
-0.013718774542212486,
-0.028310587629675865,
0.01670229062438011,
0.0017458979273214936,
0.01381691638380289,
-0.023711854591965675,
0.004813221748918295,
-0.025604411959648132,
0.017285533249378204,
0.01508873701095581,
0.04811698943376541,
0.008861720561981201,
-0.010498130694031715,
0.025187931954860687,
0.005227512679994106,
0.004992453847080469,
-0.01058537233620882,
0.004275420680642128,
0.003527100197970867,
-0.018320385366678238,
-0.008881866931915283,
0.004152760840952396,
0.004859571345150471,
0.010076288133859634,
-0.007848174311220646,
-0.03205135464668274,
-0.027233535423874855,
-0.01327342540025711,
-0.02315044403076172,
0.014375213533639908,
0.012592578306794167,
0.009957494214177132,
0.020351016893982887,
0.0011626033810898662,
-0.003452448407188058,
0.042996808886528015,
0.016074268147349358,
-0.05002438277006149,
0.0011059734970331192,
0.007965607568621635,
0.04486127942800522,
0.019827943295240402,
-0.012556915171444416,
-0.007190651260316372,
-0.016644887626171112,
0.04117727279663086,
-0.013584719970822334,
-0.004532603546977043,
-0.028559276834130287,
-0.021944444626569748,
-0.00710177980363369,
0.05686929076910019,
-0.06617535650730133,
0.04647330939769745,
0.009404356591403484,
-0.008325756527483463,
-0.005465231835842133,
0.012499768286943436,
-0.045129965990781784,
0.0045494032092392445,
0.0011776697356253862,
0.00013248471077531576,
0.01139293983578682,
-0.007040674798190594,
-0.016281230375170708,
-0.008520237170159817,
-0.015296687372028828,
-0.004551050253212452,
-0.003969727084040642,
-0.0013438821770250797,
-0.013763422146439552,
-0.014804426580667496,
-0.015745216980576515,
0.002197831869125366,
0.00805521197617054,
0.01270456612110138,
0.00017688050866127014,
-0.016298070549964905,
-0.0004526255652308464,
0.007757782936096191,
0.0147223100066185,
0.010565767996013165,
-0.014787064865231514,
0.0007762713357806206,
0.001260838471353054,
0.017749812453985214,
0.018622342497110367,
0.008415334858000278,
-0.014051232486963272,
-0.013490742072463036,
-0.033209800720214844,
-0.017625585198402405,
-0.0005217958241701126,
0.01566922478377819,
0.0020254089031368494,
-0.0043100155889987946,
-0.005680513568222523,
-0.011324286460876465,
0.02070995233952999,
-0.012237781658768654,
-0.0056892381981015205,
0.03847326338291168,
0.010010804980993271,
0.030242562294006348,
-0.004193655680865049,
0.014581373892724514,
0.0712781772017479,
-0.011089609935879707,
-0.004696706309914589,
-0.031903889030218124,
0.05399518460035324,
-0.03600587323307991,
0.014098245650529861,
0.0030768937431275845,
-0.026664184406399727,
0.012358718551695347,
0.01210760697722435,
-0.028527922928333282,
0.00013324618339538574,
-0.004378825426101685,
-0.013253260403871536,
0.0017656533746048808,
-0.015082381665706635,
-0.022570066154003143,
0.02390553057193756,
0.02900385670363903,
-0.01095077209174633,
0.012787864543497562,
0.010003216564655304,
0.011208610609173775,
-0.022598525509238243,
0.012807114981114864,
0.035259827971458435,
-0.012795168906450272,
-0.011315250769257545,
0.011273806914687157,
0.003232470713555813,
-0.020709902048110962,
-0.003556690877303481,
0.008745887316763401,
0.022823739796876907,
-0.0024100500158965588,
0.016159825026988983,
0.013759509660303593,
0.004404579289257526,
0.009216386824846268,
-0.02601204626262188,
-0.01786266639828682,
-0.036011431366205215,
0.01775960624217987,
-0.005456534214317799,
-0.006226029247045517,
-0.007551766932010651,
-0.006921613123267889,
-0.013000315055251122,
-0.018869834020733833,
-0.004442096687853336,
-0.0031815837137401104,
0.01690954715013504,
0.013980284333229065,
0.004898564890027046,
0.03513084724545479,
0.025416400283575058,
-0.0019879951141774654,
0.014950832352042198,
-0.039384979754686356,
-0.04855983704328537,
-0.016384806483983994,
-0.015213804319500923,
0.039968863129615784,
0.0013787716161459684,
-0.006020734086632729,
-0.009844591841101646,
0.0004070065915584564,
0.005348154343664646,
-0.019139917567372322,
-0.00020502950064837933,
0.006709871347993612,
-0.040010739117860794,
0.011433245614171028,
-0.03643600642681122,
0.008010601624846458,
-0.02529650181531906,
-0.003409145399928093,
0.017181556671857834,
0.014832699671387672,
-0.011159559711813927,
-0.002638045698404312,
0.04819049686193466,
-0.0038901844527572393,
-0.01452522911131382,
0.019321776926517487,
-0.015048317611217499,
-0.0738096684217453,
-0.006076302845031023,
-0.02561207488179207,
-0.004791175946593285,
0.004210381302982569,
-0.018592054024338722,
-0.003907347097992897,
-0.024227680638432503,
-0.012136828154325485,
-0.01125272549688816,
-0.03089277260005474,
-0.006309641525149345,
0.0029385967645794153,
0.005953163839876652,
0.014936747029423714,
0.03532956913113594,
-0.030166909098625183,
-0.013540982268750668,
-0.048751235008239746,
-0.030020495876669884,
-0.012060713022947311,
0.011019189842045307,
-0.0438380092382431,
-0.0001670505153015256,
-0.008507085964083672,
-0.07993467152118683,
0.009995386004447937,
-0.011998984962701797,
-0.020596381276845932,
-0.01388812530785799,
-0.007062186021357775,
0.007928924635052681,
-0.022455420345067978,
0.021606499329209328,
-0.018238496035337448,
0.030571237206459045,
-0.016765398904681206,
-0.0020123599097132683,
-0.020254381000995636,
0.028203221037983894,
-0.00902164913713932,
0.015411709435284138,
0.03201921656727791,
-0.007881736382842064,
-0.002381722442805767,
-0.033776115626096725,
0.007526247762143612,
-0.014981705695390701,
0.004226229153573513,
-0.008007043041288853,
-0.020718656480312347,
-0.00045589031651616096,
0.014484014362096786,
-0.025481782853603363,
-0.002348704729229212,
0.028917714953422546,
0.014625715091824532,
-0.023738760501146317,
-0.010276192799210548,
-0.029538994655013084,
-0.01516692340373993,
-0.010873667895793915,
-0.002673847135156393,
0.037729136645793915,
-0.007576772011816502,
-0.012920758686959743,
0.01226726919412613,
-0.012371956370770931,
0.02041049301624298,
0.011803973466157913,
0.005051432177424431,
0.00859637651592493,
0.0015689163701608777,
0.014292644336819649,
0.015681371092796326,
0.0008376295445486903,
0.007889804430305958,
0.031789381057024,
-0.018863392993807793,
0.02754870057106018,
-0.011613933369517326,
0.0022604060359299183,
0.01436111330986023,
0.003576386719942093,
0.014653821475803852,
-0.02030942030251026,
0.03030383586883545,
-0.00800718180835247,
0.07052577286958694,
-0.013824114575982094,
0.03648477420210838,
-0.0023789559490978718,
-0.0007376712746918201,
0.004769108258187771,
0.012129575945436954,
0.011258060112595558,
-0.006739288568496704,
-0.020094262436032295,
-0.02465207129716873,
-0.014845231547951698,
-0.004726117476820946,
0.009206347167491913,
-0.01854446530342102,
0.02829628624022007,
-0.018439019098877907,
0.00013944716192781925,
0.009499306790530682,
0.010922655463218689,
0.03124287724494934,
0.011362182907760143,
-0.012802713550627232,
-0.019045885652303696,
0.03270904719829559,
-0.021103978157043457,
-0.019400138407945633,
0.016128091141581535,
-0.02181614376604557,
-0.006569685414433479,
-0.014291225001215935,
0.010191253386437893,
0.0013216163497418165,
-0.0007300153374671936,
0.013988101854920387,
-0.0017866715788841248,
-0.023647133260965347,
0.006430549547076225,
0.011501681059598923,
0.0050389934331178665,
-0.045970380306243896,
-0.0030861992854624987,
-0.004354579374194145,
-0.02134246751666069,
0.009266776964068413,
-0.029002372175455093,
-0.0070624081417918205,
0.014874788001179695,
0.01103193312883377,
0.013910369016230106,
0.011621640995144844,
-0.0010797741124406457,
0.028923332691192627,
-0.0035580263938754797,
0.0037681665271520615,
0.015509351156651974,
-0.05113697052001953,
0.012288680300116539,
-0.01276683434844017,
-0.004780367948114872,
0.004577555228024721,
-0.03305983170866966,
0.019169794395565987,
-0.014344669878482819,
0.02696032077074051,
-0.0005398113280534744,
0.020434997975826263,
-0.017153684049844742,
0.009814713150262833,
0.016417212784290314,
-0.008710552006959915,
0.004443015903234482,
0.004624680615961552,
-0.02071957290172577,
0.0008668601512908936,
0.0003593401052057743,
0.04997565969824791,
-0.005943045951426029,
0.015570354647934437,
-0.013957997784018517,
0.001306905527599156,
0.007253960240632296,
0.04182438552379608,
0.013830392621457577,
-0.03836362063884735,
0.00228132214397192,
0.030396640300750732,
0.012141425162553787,
-0.005711772479116917,
0.011525845155119896,
0.02630666270852089,
0.010619141161441803,
-0.0005344283417798579,
-0.007774625439196825,
0.00679215881973505,
0.03346572816371918,
-0.006796021480113268,
0.011654907837510109,
0.012921455316245556,
-0.011919762939214706,
-0.01440335065126419,
-0.0035746123176068068,
-0.041850365698337555,
0.008557171560823917,
0.0038960501551628113,
-0.0072410013526678085,
0.022218497470021248,
0.014952762983739376,
0.020158039405941963,
0.03865745663642883,
0.02732761576771736,
-0.012516935355961323,
-0.0009706337004899979,
0.013738971203565598,
0.00859785359352827,
0.04474564641714096,
0.001976758474484086,
0.02415848709642887,
-0.046033844351768494,
-0.013124222867190838,
-0.01862974278628826,
0.00651182048022747,
0.019741959869861603,
0.023040197789669037,
-0.01418634969741106,
-0.0031346981413662434,
-0.011503550224006176,
0.020490523427724838,
-0.004907154943794012,
0.020508743822574615,
0.017798379063606262,
-0.057972945272922516,
0.0038930224254727364,
0.02412751317024231,
0.006172494031488895,
-0.011584831401705742,
-0.015769250690937042,
0.00209213700145483,
-0.0003128950484097004,
-0.014379539526998997,
0.023851148784160614,
-0.0004271692596375942,
0.00482711847871542,
-0.0021678186021745205,
0.008916864171624184,
-0.029402509331703186,
0.017528148368000984,
-0.0019030217081308365,
0.010814936831593513,
0.010067753493785858,
-0.007700658403337002,
-0.01041669026017189,
-0.017569303512573242,
-0.005227990448474884,
-0.009870910085737705,
0.006549665704369545,
-0.005740008316934109,
-0.006748700514435768,
-0.020852789282798767,
0.003972453996539116,
-0.0009336788207292557,
0.0037068543024361134,
-0.005531236529350281,
-0.0012065123300999403,
-0.005484634079039097,
-0.006893400568515062,
0.02456434816122055,
0.005426953546702862,
0.01762661524116993,
-0.005536329932510853,
0.02399648353457451,
-0.026278384029865265,
-0.02299657091498375,
0.012492269277572632,
-0.0339478962123394,
-0.011762430891394615,
-0.017935601994395256,
0.033934034407138824,
-0.027278093621134758,
0.017388148233294487,
0.0005005260463804007,
0.010116621851921082,
-0.009817804209887981,
-0.006238894537091255,
0.0020274606067687273,
-0.0006418329430744052,
-0.018113916739821434,
0.03824569284915924,
0.04729495197534561,
0.010400370694696903,
-0.013911731541156769,
-0.011039875447750092,
-0.005359557922929525,
0.004137829411774874,
0.006255229935050011,
-0.0288047194480896,
-0.008832458406686783,
0.03838589787483215,
-0.001524392981082201,
0.0038948426954448223,
-0.006029848009347916,
-0.006449347827583551
] | [
0.35609981417655945,
0.04547945782542229,
-0.32981428503990173,
0.2322136014699936,
0.2575823962688446,
0.23541946709156036,
-0.14646011590957642,
-0.5359336137771606,
0.20802685618400574,
-0.4913555681705475,
0.3255176544189453,
0.332309752702713,
0.10559593886137009,
0.11433504521846771,
-0.18453316390514374,
0.5316121578216553,
0.1469152867794037,
0.22278571128845215,
-0.06062343344092369,
-0.48135101795196533,
-0.0653863251209259,
-0.3807216286659241,
0.2490168958902359,
0.30788323283195496,
0.042280275374650955,
0.05647605285048485,
0.46559134125709534,
-0.18569588661193848,
0.2446225881576538,
-0.25824174284935,
-0.35228267312049866,
0.21146084368228912,
-0.37551331520080566,
-0.4118850529193878,
0.08697544783353806,
-0.17537406086921692,
-0.2800590991973877,
0.4950507581233978,
0.14733140170574188,
-0.20002447068691254,
-0.2371821254491806,
0.17862316966056824,
0.021640151739120483,
0.4422520399093628,
-0.22679342329502106,
-0.5050806999206543,
-1.392210841178894,
0.5364566445350647,
-0.22482649981975555,
-0.3152480125427246,
0.49425387382507324,
0.12783282995224,
0.31866776943206787,
0.17538371682167053,
-0.04476788640022278,
0.42137476801872253,
-0.26511460542678833,
-0.18317466974258423,
0.2325136959552765,
-0.6347965598106384,
0.051260028034448624,
0.0064576417207717896,
-0.3178682327270508,
-0.12190370261669159,
0.13681675493717194,
0.6676764488220215,
0.32519328594207764,
-0.43791866302490234,
0.10431256145238876,
-0.24624641239643097,
0.044262487441301346,
-0.19277280569076538,
-0.3527890741825104,
0.35128965973854065,
-0.06058328226208687,
-0.0688011646270752,
0.2900328040122986,
-0.40296247601509094,
0.20931066572666168,
0.02515578642487526,
-0.33919283747673035,
-0.4692087769508362,
0.09039323776960373,
-0.1917823851108551,
0.4589639902114868,
0.40609005093574524,
-0.14552722871303558,
0.09096207469701767,
-0.6572440266609192,
-0.1726960986852646,
-0.4733685255050659,
-0.36291369795799255,
0.3639300465583801,
0.766539454460144,
0.20786863565444946,
0.5126276016235352,
0.11587229371070862,
0.033957917243242264,
-0.033192384988069534,
0.3573203980922699,
-0.7006735801696777,
-0.26239973306655884,
-0.14280672371387482,
-0.1253654658794403,
-0.4428197145462036,
-0.3414629399776459,
-0.5261030197143555,
-0.520524263381958,
-0.6440978050231934,
0.11953457444906235,
-0.07532122731208801,
0.30246400833129883,
-0.3340904116630554,
-0.0925585925579071,
-0.27265816926956177,
-0.06822876632213593,
0.06945493072271347,
-0.4647537171840668,
-0.3153400123119354,
0.686306357383728,
-0.32217076420783997,
1.808083415031433,
-0.273516446352005,
0.04282967373728752,
-0.07957235723733902,
0.08985655009746552,
0.4947461783885956,
0.2552398145198822,
-0.21272006630897522,
0.3801143169403076,
0.007241309154778719,
0.6774460673332214,
-0.5235931277275085,
0.4601697623729706,
-0.2219029814004898,
0.06143781542778015,
0.08570762723684311,
0.3770413398742676,
-0.1338077038526535,
-0.013425704091787338,
-0.5127330422401428,
-0.7908398509025574,
-0.24350066483020782,
0.22319969534873962,
0.42168059945106506,
-0.5404181480407715,
-0.17982028424739838,
-0.046815481036901474,
-0.20435865223407745,
0.1578661948442459,
0.04663939028978348,
-0.26626524329185486,
-0.5892581939697266,
-0.0253091249614954,
-0.09898946434259415,
0.7129876613616943,
-0.2865864038467407,
-0.0819035992026329,
-0.23537638783454895,
0.4288768172264099,
0.3499522805213928,
0.2725284993648529,
-0.5147482752799988,
-0.2043023556470871,
0.19154290854930878,
0.10931398719549179,
0.6156457662582397,
0.3279159367084503,
-0.173057422041893,
-0.03345418721437454,
-0.27902698516845703,
-0.3069039583206177,
-0.15661999583244324,
-0.7251075506210327,
-0.27840152382850647,
0.30302396416664124,
0.3266611397266388,
-0.06254921853542328,
0.192240908741951,
0.1855006068944931,
-0.5439549684524536,
-0.29585981369018555,
-0.6557626128196716,
-0.5899995565414429,
0.2541085481643677,
-0.14555072784423828,
0.334951251745224,
0.07546772807836533,
0.14346905052661896,
0.18234099447727203,
-0.41884472966194153,
-0.47499924898147583,
0.8131462931632996,
-1.0337889194488525,
1.3885548114776611,
-0.4049364924430847,
-0.027052948251366615,
1.559705138206482,
0.4068845510482788,
0.08400196582078934,
0.1011958122253418,
0.12529104948043823,
0.16339780390262604,
-0.5593574643135071,
0.02216309681534767,
0.14599233865737915,
0.19545987248420715,
-0.41247105598449707,
0.14553363621234894,
0.2773464024066925,
0.5688920021057129,
0.10576319694519043,
0.07647906243801117,
-0.043210145086050034,
0.1480686068534851,
-0.0035679712891578674,
-0.23930132389068604,
0.013122049160301685,
-0.14874699711799622,
-0.06844685971736908,
0.4770086109638214,
-0.4338901937007904,
0.7403252124786377,
0.2893901467323303,
0.02748418226838112,
0.811844527721405,
0.07503733038902283,
-0.14587460458278656,
0.9753948450088501,
-0.4474400579929352,
0.3090589642524719,
-0.4565226137638092,
0.27501603960990906,
-0.4346337914466858,
-0.42253604531288147,
0.005781620740890503,
0.1600111424922943,
-0.03471191227436066,
0.08126311749219894,
0.41285187005996704,
-0.10290754586458206,
0.6771121025085449,
-0.7688300013542175,
-0.268206387758255,
-0.3665502369403839,
-0.5316551923751831,
-0.21081626415252686,
0.12594281136989594,
-0.6529725193977356,
-0.2945505678653717,
0.08951320499181747,
-0.011661794036626816,
0.2688571512699127,
-0.19107307493686676,
0.10796919465065002,
-0.012120448984205723,
-0.35035982728004456,
-0.7183058857917786,
0.3033679127693176,
-0.23631052672863007,
0.12122746556997299,
0.18691986799240112,
0.3453494608402252,
-0.0017651859670877457,
0.4677491784095764,
-0.39688000082969666,
-0.4584134817123413,
-0.6836152076721191,
0.9518391489982605,
0.8329468965530396,
0.7907220721244812,
-0.03561866655945778,
-0.13670991361141205,
0.17512956261634827,
0.26532357931137085,
-0.8439584374427795,
0.030544864013791084,
0.6862114667892456,
-0.47101712226867676,
-0.5302954912185669,
-0.05760113149881363,
0.24645379185676575,
0.5350766777992249,
-0.04330772906541824,
-0.24796180427074432,
-0.3427783250808716,
-0.1873641312122345,
-0.1030050665140152,
-0.6004058718681335,
0.08317869156599045,
-0.02025793120265007,
0.41018036007881165,
-0.2568943500518799,
-0.5206907987594604,
0.5516865849494934,
0.6627047657966614,
0.10983327031135559,
0.20828911662101746,
0.4721764028072357,
0.2366301417350769,
-0.3993279039859772,
0.35634541511535645,
-0.2764914333820343,
-0.1291828155517578,
0.11469415575265884,
-0.09185075759887695,
-0.552002489566803,
0.3538800776004791,
-6.010207176208496,
0.09743610769510269,
-0.13167044520378113,
0.18832062184810638,
-0.03956418111920357,
0.1977567821741104,
1.0476160049438477,
0.12445467710494995,
0.2753131687641144,
-0.3559080958366394,
0.40014684200286865,
0.39091500639915466,
-0.11081826686859131,
0.09068768471479416,
0.017499003559350967,
0.08637264370918274,
0.16132836043834686,
-0.1425621211528778,
0.6583451628684998,
0.38402479887008667,
0.10214746743440628,
-0.070808544754982,
-0.3534681499004364,
0.626127302646637,
0.47490960359573364,
0.32772740721702576,
-1.1769300699234009,
0.5496683120727539,
-0.10841071605682373,
-0.03270632028579712,
0.6766201853752136,
-0.9240827560424805,
-0.10330292582511902,
-0.3002428412437439,
0.13670186698436737,
0.3364675045013428,
0.03575139865279198,
-0.0498456135392189,
0.11398530006408691,
-0.32939425110816956,
0.43413811922073364,
0.25860169529914856,
-0.5007814168930054,
-0.2885807156562805,
0.14802943170070648,
-0.35493147373199463,
-0.052455879747867584,
0.1740041822195053,
0.19187919795513153,
0.5090611577033997,
-0.06830761581659317,
0.17286211252212524,
0.3693174719810486,
0.6208241581916809,
0.12267431616783142,
-0.16041773557662964,
-0.1438286304473877,
0.4110354483127594,
-0.439270555973053,
0.09496214985847473,
-0.04650891572237015,
-0.2552383840084076,
-0.16289757192134857,
-0.6468430161476135,
-0.12141256034374237,
0.18658718466758728,
-0.42194464802742004,
-0.29212507605552673,
-0.3855743110179901,
0.11320094019174576,
-0.06284424662590027,
0.15964800119400024,
-0.11711622029542923,
-0.6419892907142639,
0.19817756116390228,
-0.24563270807266235,
-0.31872040033340454,
-0.0936480239033699,
0.05421525985002518,
0.01869073323905468,
-0.11730697005987167,
-0.28261134028434753,
0.38913556933403015,
-0.014417516067624092,
0.08690770715475082,
0.07550188899040222,
-0.0171237550675869,
-0.19266372919082642,
-0.4966222047805786,
0.1984790712594986,
0.3663490414619446,
-0.2594519555568695,
0.1369241178035736,
0.5933160185813904,
0.3451538383960724,
0.18052202463150024,
0.19894325733184814,
0.2255793958902359,
0.5213321447372437,
-0.03976559266448021,
0.7289822697639465,
-0.011101162992417812,
-0.28711122274398804,
-1.010773777961731,
-0.1893344521522522,
0.11977894604206085,
-0.6426044702529907,
-0.1041741892695427,
0.6062765121459961,
-0.7109540700912476,
-0.1748352348804474,
0.0943237915635109,
-0.08355189114809036,
0.09137530624866486,
0.7186837792396545,
-0.14550217986106873,
0.379086971282959,
-0.16582506895065308,
1.0973308086395264,
-0.25337541103363037,
0.4928891062736511,
0.08906607329845428,
-0.29614126682281494,
0.4745423495769501,
0.4479388892650604,
-0.5110461711883545,
0.4519977867603302,
0.6346321702003479,
-0.7538323998451233,
-0.48125818371772766,
0.2528611421585083,
0.07545866072177887,
-0.6240148544311523,
0.20217184722423553,
0.2829481065273285,
-0.16263838112354279,
-0.488807737827301,
-0.2965572774410248,
0.1653178632259369,
-0.08119375258684158,
0.3786710202693939,
-0.32666075229644775,
-0.06045150384306908,
0.2204318344593048,
0.12788061797618866,
0.12508447468280792,
-0.018456626683473587,
0.2246456891298294,
-0.4959854781627655,
-0.19192975759506226,
0.09332408756017685,
0.025479234755039215,
0.15268291532993317,
-0.3404991626739502,
-0.4989240765571594,
0.4341084659099579,
0.8247360587120056,
0.07769151031970978,
0.2743286192417145,
-0.30756932497024536,
0.49196046590805054,
0.08066438138484955,
-0.712173342704773,
0.18885765969753265,
-0.2610374689102173,
-0.6401764750480652,
-0.09969307482242584,
-0.2866728901863098,
0.0606129989027977,
0.34360653162002563,
-0.12837526202201843,
-0.22210650146007538,
0.06576326489448547,
-0.28100118041038513,
0.13855282962322235,
-0.14093516767024994,
-0.22151441872119904,
0.25941309332847595,
-0.10239710658788681,
-0.05406564101576805,
0.22679196298122406,
-0.5480592846870422,
-0.2730186879634857,
0.4299708604812622,
0.8919130563735962,
0.7944899797439575,
0.08766509592533112,
-0.08203127980232239,
-0.7948662638664246,
-0.326414555311203,
-0.4551730453968048,
0.06046006456017494,
0.6551955938339233,
0.0394766740500927,
-0.22236517071723938,
0.04170728847384453,
-0.04690851643681526,
0.2599276006221771,
-0.060074981302022934,
-0.4995681941509247,
0.1975988894701004,
0.3805592656135559,
-0.5448405146598816,
0.4993797838687897,
0.18946963548660278,
-0.0965515673160553,
-0.30225586891174316,
-0.10883524268865585,
0.25101426243782043,
-0.2751332223415375,
0.02514936402440071,
-0.3033742308616638,
-0.0855255126953125,
0.22096885740756989,
-0.0976158007979393,
0.12207324057817459,
0.31989362835884094,
-0.09006880968809128,
0.005038408562541008,
0.5248781442642212,
0.0556614063680172,
-0.0829794779419899,
-0.09340453892946243,
0.11745036393404007,
-0.23351064324378967,
0.006568448152393103,
0.5684086680412292,
-0.78743976354599,
-0.5341594219207764,
0.19396652281284332,
-0.38926389813423157,
-0.27876579761505127,
-0.020132800564169884,
-0.008069680072367191,
-0.5673093199729919,
-0.0048412601463496685,
-0.12699447572231293,
0.022617636248469353,
0.22089643776416779,
0.2500915229320526,
0.6259995698928833,
0.33041584491729736,
-0.4034813940525055,
-0.21967269480228424,
-0.24340645968914032,
0.35880404710769653,
0.3212518095970154,
-0.03160890191793442,
-0.13548724353313446,
-0.021157147362828255,
0.2405364066362381,
-0.030717013403773308,
0.008270959369838238,
0.06324614584445953,
0.842508852481842,
0.0513349249958992,
-0.0022263783030211926,
-0.3364900052547455,
-0.15777187049388885,
0.25552648305892944,
0.13604816794395447,
-0.2144003063440323,
-0.4606430232524872,
-0.5594531893730164,
0.002580586588010192,
-0.012521173804998398,
-0.09022998809814453,
-0.15472382307052612,
0.2680901288986206,
-0.04203442111611366,
-0.1646415740251541,
0.39343488216400146,
0.3416970372200012,
0.6978706121444702,
-0.2539155185222626,
0.06872376799583435,
-0.32277876138687134,
0.13696728646755219,
-0.23964090645313263,
0.16038483381271362,
-0.46477046608924866,
-0.5085060000419617,
0.14665262401103973,
-0.3155727684497833,
0.18964771926403046,
-0.5104638934135437,
0.08295930176973343,
-0.2449757605791092,
0.39580684900283813,
-0.5506002306938171,
-0.18563973903656006,
-0.03610512614250183,
-0.5686397552490234,
-0.3940149247646332,
0.17505311965942383,
0.2439492642879486,
0.04691115766763687,
0.3279096186161041,
0.36718258261680603,
-0.21009661257266998,
-0.6407961845397949,
0.7982829213142395,
0.2531668543815613,
-0.5025729537010193,
0.16093114018440247,
0.3002936840057373,
0.643669068813324,
0.49577659368515015,
-0.13485756516456604,
-0.049440156668424606,
0.2992604076862335,
-0.39981523156166077,
0.23923663794994354,
-0.17107467353343964,
-0.4517286419868469,
-0.08067068457603455,
-0.31886544823646545,
-0.7313221096992493,
0.44309329986572266,
0.14980554580688477,
0.437854140996933,
0.5484142303466797,
0.6497279405593872,
-0.20820054411888123,
-0.2751432955265045,
0.5769532918930054,
-0.3195502460002899,
0.012871591374278069,
-0.2633592486381531,
0.029330343008041382,
0.45129919052124023,
0.5870588421821594,
-0.29652121663093567,
0.07575330883264542,
0.2715711295604706,
0.7509749531745911,
0.21250011026859283,
-0.36293506622314453,
-0.10052470862865448,
-0.01856420934200287,
0.44289934635162354,
0.23381002247333527,
-0.37338146567344666,
-0.530536413192749,
0.19193510711193085,
0.14406654238700867,
0.0009653597371652722,
0.5174797177314758,
-0.15354223549365997,
0.2751463055610657,
-0.1333255022764206,
-0.07817891985177994,
-0.36790576577186584,
-0.019775990396738052,
-0.06370518356561661,
0.1221199706196785,
0.6528717279434204,
-0.2970455586910248,
-0.7503163814544678,
0.33018603920936584,
0.18228326737880707,
0.3711388409137726,
0.21767808496952057,
0.6683043837547302,
-0.195796400308609,
0.06763570010662079,
0.0732792317867279,
0.17504025995731354,
0.16127875447273254,
-0.15121224522590637,
-0.2571612000465393,
-0.3399399220943451,
-0.37949320673942566,
-0.017110953107476234,
0.06518860906362534,
-0.4642069935798645,
-0.08340136706829071,
-0.3186502158641815,
-0.336327463388443,
0.6419351696968079,
-0.21582511067390442,
-0.07001420110464096,
-0.11437846720218658,
-0.3787864148616791,
0.07793308049440384,
-0.22244252264499664,
-0.01873934455215931,
0.004697212018072605,
0.3830050528049469,
-0.013304948806762695,
0.2563629746437073,
-1.0313985347747803,
-0.053851183503866196,
0.19863779842853546,
-0.12260103970766068,
0.0028719808906316757,
-0.34723401069641113,
0.34861746430397034,
0.22212573885917664,
0.23414303362369537,
-0.004223215393722057,
0.23501309752464294,
0.05155498534440994,
0.7799370884895325,
-0.47105997800827026,
0.4302658140659332,
-0.8678817749023438,
-0.20925988256931305,
-0.8023291826248169,
-0.23572610318660736,
0.5458580255508423,
0.022816788405179977,
-0.3427782952785492,
-0.08304145187139511,
0.2039071023464203,
0.21210458874702454,
0.19150228798389435,
-0.27140679955482483,
-0.1598016768693924,
-0.06434383243322372,
0.15293118357658386,
-0.4033012092113495,
0.5035167932510376,
0.2856235206127167,
-0.4410255253314972,
-0.32188498973846436,
0.34154799580574036,
0.5100533962249756,
-0.30722010135650635,
0.2844686806201935,
-0.16678474843502045,
-0.07745389640331268,
-0.6504780650138855,
0.3071717619895935,
-0.4817007780075073,
-0.10616496950387955,
-0.1774670034646988,
0.3037429451942444,
-0.19833555817604065,
-0.22637270390987396,
-0.18425655364990234,
-0.11937379091978073,
0.3935147821903229,
0.3982658386230469,
-0.021896090358495712,
0.30231496691703796,
0.1666126847267151,
-0.42274653911590576,
-0.8112180829048157,
0.4710095524787903,
-0.2766519784927368,
-0.4175550043582916,
0.08775055408477783,
-0.023769812658429146,
-0.4471718966960907,
0.2660928964614868,
-0.10239118337631226,
-0.6140217185020447,
-0.14297278225421906,
-0.2628471553325653
] |
‘Recoding’ is a term used to describe non-standard read-out of the genetic code, and encompasses such phenomena as programmed ribosomal frameshifting, stop codon readthrough, selenocysteine insertion and translational bypassing. Although only a small proportion of genes utilize recoding in protein synthesis, accurate annotation of ‘recoded’ genes lags far behind annotation of ‘standard’ genes. In order to address this issue, provide a service to researchers in the field, and offer training data for developers of gene-annotation software, we have gathered together known cases of recoding within the Recode database. Recode-2 is an improved and updated version of the database. It provides access to detailed information on genes known to utilize translational recoding and allows complex search queries, browsing of recoding data and enhanced visualization of annotated sequence elements. At present, the Recode-2 database stores information on approximately 1500 genes that are known to utilize recoding in their expression—a factor of approximately three increase over the previous version of the database. Recode-2 is available at http://recode.ucc.ie | [
0.01104835793375969,
0.01264684647321701,
-0.004759513773024082,
0.010824205353856087,
-0.010200684890151024,
-0.023105738684535027,
0.008129701018333435,
-0.01212802343070507,
-0.011155258864164352,
-0.00409552501514554,
-0.0037295520305633545,
0.00506988912820816,
0.019038978964090347,
0.008148321881890297,
-0.010441718623042107,
0.017848817631602287,
-0.010985995642840862,
0.02266717702150345,
0.008574796840548515,
0.007383552845567465,
0.004103320650756359,
-0.001399264670908451,
0.0071197617799043655,
0.0043172589503228664,
0.024376820772886276,
0.01604628562927246,
0.005315463058650494,
0.025106623768806458,
-0.015786737203598022,
-0.010623430833220482,
-0.0028084246441721916,
-0.003729004180058837,
0.02231590822339058,
0.014744363725185394,
0.007613164838403463,
0.002828672295436263,
-0.0014161725994199514,
0.014019847847521305,
0.03750496357679367,
-0.0038690478540956974,
-0.006269867531955242,
-0.008922383189201355,
0.003724456299096346,
0.002439487027004361,
-0.005803829990327358,
0.003360491245985031,
0.0025163814425468445,
0.015571177937090397,
-0.010651353746652603,
0.0033893983345478773,
-0.013050325214862823,
-0.005804850719869137,
0.005669584032148123,
0.03425191715359688,
-0.004207573365420103,
-0.016796303912997246,
0.013902167789638042,
0.0029872555751353502,
-0.006863669492304325,
-0.0067366003058850765,
0.01340743899345398,
0.00779074989259243,
0.015855591744184494,
-0.02290024235844612,
-0.015739023685455322,
-0.06754378974437714,
0.011752445250749588,
0.007158154621720314,
-0.00003178918268531561,
-0.028279665857553482,
-0.0031426141504198313,
0.0042871939949691296,
-0.011789876967668533,
-0.02952188439667225,
0.009219828061759472,
-0.013874629512429237,
-0.00630294531583786,
0.003055179724469781,
0.015417389571666718,
-0.011635420843958855,
-0.03985520079731941,
-0.004387723281979561,
0.012433966621756554,
0.006477732677012682,
0.0021718712523579597,
0.008149044588208199,
-0.010648733004927635,
-0.015343347564339638,
-0.0017902161926031113,
-0.023056387901306152,
0.019908368587493896,
-0.017029084265232086,
-0.02797188237309456,
0.005697520915418863,
-0.01818094588816166,
0.03321735933423042,
0.00973653793334961,
-0.02085915580391884,
0.0027417989913374186,
-0.01098166685551405,
-0.011127147823572159,
0.013110351748764515,
0.014815542846918106,
0.0027211299166083336,
0.006507899146527052,
0.01208290085196495,
0.008227154612541199,
0.022269507870078087,
-0.003332718275487423,
0.007171816658228636,
0.015022063627839088,
0.014905709773302078,
-0.009221227839589119,
0.00029951659962534904,
0.010989590547978878,
0.025467710569500923,
0.00537167489528656,
-0.005080264061689377,
0.0030886027961969376,
0.001225125975906849,
-0.008854388259351254,
0.002197420224547386,
0.013198919594287872,
-0.009422884322702885,
0.0039034541696310043,
-0.0007103444077074528,
-0.0006535637658089399,
-0.010256659239530563,
0.0031766234897077084,
0.022547435015439987,
-0.00728423148393631,
0.001109887263737619,
-0.006287416908890009,
-0.0344371572136879,
0.0037470103707164526,
-0.003240554593503475,
-0.008028092794120312,
0.003470746334642172,
-0.000449516111984849,
-0.006666445638984442,
0.021044518798589706,
0.00478763971477747,
0.0033595971763134003,
0.009707693010568619,
0.029511816799640656,
0.0059084221720695496,
0.010929862037301064,
0.0038175785448402166,
0.012174393981695175,
-0.008659877814352512,
-0.002504542004317045,
0.001418609288521111,
0.0007606688886880875,
-0.006046753842383623,
0.010141324251890182,
0.014057358726859093,
-0.017904192209243774,
-0.01740775629878044,
0.011113512329757214,
0.013072957284748554,
0.02543921209871769,
-0.013665828853845596,
0.00516427680850029,
0.0044971369206905365,
-0.0020634287502616644,
-0.016596220433712006,
-0.010243779979646206,
0.006144240032881498,
-0.02302904985845089,
0.0015745243290439248,
0.001968013821169734,
0.01631152629852295,
0.0017441143281757832,
0.0044919331558048725,
-0.01868170127272606,
-0.009727337397634983,
0.006582268513739109,
0.005987357348203659,
-0.010551219806075096,
0.06723950803279877,
-0.013251498341560364,
0.0017833895981311798,
-0.01462449599057436,
0.0217727180570364,
-0.014600573107600212,
-0.0013878976460546255,
0.01371301244944334,
-0.005483073182404041,
-0.011525275185704231,
0.011226804926991463,
-0.0050659338012337685,
-0.00512328464537859,
-0.0005003456026315689,
0.019890299066901207,
-0.002085999120026827,
0.0032865360844880342,
-0.0025895792059600353,
0.006958554498851299,
0.004526800941675901,
-0.000343947671353817,
-0.016714878380298615,
-0.01467327494174242,
-0.007555211428552866,
-0.012869511730968952,
0.005966678261756897,
0.002413966692984104,
-0.01654064655303955,
0.004742065444588661,
0.00910106860101223,
-0.0011984219308942556,
0.02599044144153595,
0.011308819986879826,
-0.02290266752243042,
0.0029793372377753258,
0.003053504740819335,
-0.0012813680805265903,
-0.004845812916755676,
-0.01709587499499321,
0.042548686265945435,
-0.013666483573615551,
0.003720860695466399,
-0.023815248161554337,
0.011542598716914654,
-0.014989477582275867,
0.002228064928203821,
0.01849459856748581,
0.00693939533084631,
0.009853465482592583,
-0.0074773565866053104,
-0.000003999681212007999,
0.007135133724659681,
-0.0151645103469491,
-0.005210248287767172,
0.014259759336709976,
0.03327285498380661,
-0.0038684639148414135,
0.0038959751836955547,
0.012300357222557068,
0.0033539915457367897,
-0.004220065660774708,
-0.00888685043901205,
0.02204705774784088,
-0.003461357904598117,
0.013834627345204353,
-0.02254193276166916,
-0.007964449934661388,
0.009900284931063652,
0.009901480749249458,
-0.0004648091271519661,
-0.007607581559568644,
0.00009182117355521768,
0.010862124152481556,
0.021265115588903427,
0.01219218596816063,
0.01968764327466488,
0.01165049523115158,
-0.022654177621006966,
-0.00863504596054554,
0.022361278533935547,
-0.0030007236637175083,
-0.006641631945967674,
0.004118930548429489,
-0.011170846410095692,
-0.012715822085738182,
-0.016118761152029037,
0.014798750169575214,
0.018178552389144897,
0.015384113416075706,
0.009267628192901611,
-0.01841459423303604,
0.0027378476224839687,
-0.011357346549630165,
0.006400341168045998,
-0.0822967141866684,
-0.001543304300867021,
0.007376327645033598,
-0.003451479133218527,
0.004127573221921921,
-0.005191300064325333,
-0.005942519288510084,
-0.0030451708007603884,
-0.013123612850904465,
0.01817518100142479,
0.016294147819280624,
0.004821565933525562,
-0.014225722290575504,
0.003967665135860443,
-0.004167777020484209,
-0.018018797039985657,
0.011083772405982018,
-0.01127196941524744,
-0.011169841513037682,
0.014781320467591286,
0.012059733271598816,
0.0032276217825710773,
0.0012559131719172,
-0.0060381051152944565,
-0.01749899983406067,
0.00256981048732996,
-0.008144812658429146,
-0.00859569851309061,
-0.014899746514856815,
0.0017269962700083852,
-0.012285749427974224,
-0.02782289683818817,
0.01104369293898344,
-0.021425511687994003,
-0.0021310499869287014,
0.00974989589303732,
-0.026740482077002525,
-0.013728850521147251,
-0.014236051589250565,
0.017917446792125702,
0.005722863599658012,
-0.000057820521760731936,
-0.009082090109586716,
0.009239115752279758,
0.016140084713697433,
0.02745548076927662,
-0.011896482668817043,
0.02774682268500328,
0.011092731729149818,
0.010554313659667969,
-0.00645958399400115,
-0.007995251566171646,
0.007155807688832283,
0.0074865929782390594,
-0.006926779635250568,
0.014200293458998203,
-0.0034572798758745193,
-0.005167727824300528,
-0.009446964599192142,
-0.004127005580812693,
-0.003991925157606602,
0.028024878352880478,
-0.01493414118885994,
-0.011122170835733414,
0.011710228398442268,
-0.003414228092879057,
0.02028472349047661,
-0.007089283317327499,
0.005303646437823772,
-0.0006459970027208328,
-0.0014434019103646278,
-0.012269909493625164,
-0.0019518218468874693,
0.0035851383581757545,
0.0061797224916517735,
-0.007973447442054749,
-0.0053763012401759624,
0.0011376955080777407,
0.008927972055971622,
0.00021803448908030987,
-0.020226476714015007,
0.007383786141872406,
-0.014003372751176357,
-0.005949302110821009,
-0.01844511181116104,
-0.034997113049030304,
0.0014636981068179011,
0.02271105721592903,
0.00942930206656456,
-0.017768152058124542,
0.01290054526180029,
0.02363070659339428,
-0.01586458832025528,
0.013193960301578045,
-0.0010214955545961857,
-0.045239515602588654,
-0.005486978683620691,
0.003323547076433897,
-0.0003772107884287834,
0.007646679412573576,
-0.023955535143613815,
0.008882798254489899,
0.020097414031624794,
-0.010544320568442345,
0.015921451151371002,
0.004710160195827484,
-0.017482314258813858,
0.00018496159464120865,
0.025330226868391037,
-0.002644144929945469,
0.01387038268148899,
0.006211455445736647,
-0.0058586327359080315,
0.011149569414556026,
0.008401559665799141,
-0.008384439162909985,
-0.0019385346677154303,
0.007220960222184658,
0.0733412578701973,
0.0004068920388817787,
-0.004479246214032173,
-0.020571401342749596,
-0.00256888335570693,
0.0011074028443545103,
-0.0034723076969385147,
0.001125335693359375,
0.010769524611532688,
0.020186223089694977,
0.010315800085663795,
0.004680558107793331,
0.018801989033818245,
-0.0011365144746378064,
0.003817933611571789,
0.009871882386505604,
0.01883670873939991,
-0.007564861327409744,
0.0030575988348573446,
0.003519435878843069,
-0.014484025537967682,
-0.046678632497787476,
-0.004159183241426945,
-0.013710159808397293,
-0.02121220901608467,
-0.014135085046291351,
0.01077461801469326,
-0.013346448540687561,
0.0025648348964750767,
0.0026346989907324314,
0.00550835020840168,
0.011879874393343925,
-0.0009646162507124245,
0.00780046172440052,
-0.008476805873215199,
-0.003997082356363535,
0.010870268568396568,
-0.003563454607501626,
-0.010563534684479237,
0.011743631213903427,
0.016108110547065735,
-0.010188579559326172,
-0.013016347773373127,
0.017061281949281693,
0.008542822673916817,
-0.01504557952284813,
0.02877560257911682,
-0.002535780193284154,
0.01020359992980957,
0.013424670323729515,
-0.0069575984962284565,
0.002448535291478038,
0.007346315775066614,
0.007258158177137375,
0.014677032828330994,
-0.025974594056606293,
0.01592385210096836,
-0.008213185705244541,
0.00916540902107954,
-0.011012155562639236,
-0.01690867729485035,
-0.016536297276616096,
-0.013095161877572536,
0.004326180554926395,
-0.002787519246339798,
-0.0035416148602962494,
-0.006645817309617996,
-0.01197885163128376,
-0.00041397102177143097,
-0.0004194555804133415,
0.01410991232842207,
0.002012757584452629,
-0.019402669742703438,
-0.030463937669992447,
-0.022832021117210388,
-0.018256420269608498,
0.01738310605287552,
0.0022099551279097795,
0.006481601856648922,
-0.0014044921845197678,
-0.0018202108331024647,
0.027092184871435165,
0.007328314241021872,
0.012146585620939732,
0.03396843746304512,
0.014545144513249397,
-0.0012987907975912094,
-0.07564912736415863,
-0.008301574736833572,
0.016113191843032837,
-0.003844607388600707,
0.028659529983997345,
0.011560685932636261,
0.0027628056704998016,
0.01234213076531887,
0.023082196712493896,
0.002852188190445304,
0.02563520334661007,
-0.009712225757539272,
-0.010064446367323399,
-0.008181659504771233,
0.006030963733792305,
0.004233970306813717,
-0.011150866746902466,
0.0033803978003561497,
-0.0010542715899646282,
0.023270580917596817,
-0.005605900660157204,
-0.00464244419708848,
0.014267364516854286,
0.01545325480401516,
-0.018088676035404205,
-0.08232748508453369,
0.014660447835922241,
-0.0035708490759134293,
-0.006601604633033276,
-0.005369821563363075,
0.009744565933942795,
-0.014926476404070854,
-0.01776745170354843,
0.015719160437583923,
-0.013500139117240906,
-0.0037314824294298887,
0.0025461632758378983,
-0.007702188566327095,
0.0007213646895252168,
0.005642253905534744,
0.002118402160704136,
0.008362754248082638,
-0.0008372059091925621,
-0.006627419497817755,
-0.002236521802842617,
0.00463545136153698,
0.0040673743933439255,
-0.007983255200088024,
0.0022041043266654015,
-0.009493466466665268,
-0.0027938359417021275,
-0.0027469350025057793,
0.01021662075072527,
0.00776709383353591,
0.004837516695261002,
0.01469520665705204,
-0.016242334619164467,
-0.011307993903756142,
-0.01836399920284748,
0.008346706628799438,
-0.007881402969360352,
-0.00016767485067248344,
0.0051119644194841385,
-0.008331351913511753,
-0.013464772142469883,
-0.004076950717717409,
0.002419896423816681,
-0.009904381819069386,
-0.005418721120804548,
0.013418931514024734,
-0.018936239182949066,
0.0009494494879618287,
-0.006714708171784878,
0.0054189180955290794,
0.023214668035507202,
0.0055811358615756035,
0.008441731333732605,
0.018138248473405838,
0.0008155649993568659,
0.019534321501851082,
0.022361908107995987,
-0.007243765518069267,
0.0006659682840108871,
0.0168303195387125,
0.004977860953658819,
-0.0031578599009662867,
-0.010457349009811878,
-0.010848013684153557,
0.07224427163600922,
0.0035863169468939304,
0.013889700174331665,
0.0030281059443950653,
-0.0005917043890804052,
-0.005171678494662046,
-0.003210614435374737,
0.0031344268936663866,
-0.017222976312041283,
0.007929039187729359,
0.01105446182191372,
-0.0003349214675836265,
0.002567653078585863,
0.006980333477258682,
0.01831485517323017,
0.018255457282066345,
-0.009785819798707962,
-0.005392366088926792,
-0.004974497947841883,
-0.002631640527397394,
-0.006993940100073814,
-0.01664472185075283,
-0.001992602366954088,
0.014454059302806854,
0.0019521911162883043,
-0.00249257730320096,
0.02613704279065132,
-0.009219621308147907,
0.004127295222133398,
-0.0073765660636126995,
-0.01906946673989296,
0.007073697634041309,
-0.00199268851429224,
0.006220404524356127,
0.014547622762620449,
-0.0068364436738193035,
-0.017218492925167084,
-0.003512136870995164,
-0.0020666425116360188,
0.0012957942672073841,
-0.02093653753399849,
-0.004703081678599119,
0.00645060557872057,
-0.012425679713487625,
0.02084331586956978,
0.0030648629181087017,
0.008982688188552856,
0.008606777526438236,
0.02639414742588997,
-0.005519375670701265,
0.031775083392858505,
-0.0055530499666929245,
-0.007143914699554443,
-0.008308377116918564,
0.010876216925680637,
-0.014122986234724522,
-0.028661489486694336,
0.004629297647625208,
0.014039329253137112,
-0.0033402664121240377,
0.00688876723870635,
-0.007650116458535194,
-0.014027226716279984,
-0.009145312011241913,
0.00646206084638834,
-0.0366380512714386,
-0.015041647478938103,
-0.012121463194489479,
0.011452900245785713,
0.016916919499635696,
-0.00838500913232565,
0.001351648010313511,
0.002025999128818512,
0.009243709966540337,
0.02209720015525818,
-0.004730127286165953,
-0.006559126079082489,
-0.005736279767006636,
-0.004271893762052059,
-0.0038474658504128456,
-0.010365763679146767,
0.018334519118070602,
-0.012831888161599636,
-0.018271232023835182,
-0.03707481175661087,
0.002246527699753642,
-0.015283284708857536,
0.0009726709686219692,
-0.005491647869348526,
0.005945440381765366,
0.012155452743172646,
0.003535008290782571,
0.007598867639899254,
-0.004881042055785656,
0.010087727569043636,
0.03390387445688248,
-0.006391003727912903,
0.008866439573466778,
-0.003540660720318556,
0.01665050908923149,
0.027860000729560852,
0.008171717636287212,
0.008448838256299496,
0.009695359505712986,
-0.02311778999865055,
-0.014636155217885971,
-0.0069540259428322315,
-0.015333788469433784,
0.002380968537181616,
-0.02508058212697506,
0.0279708094894886,
0.0024838102981448174,
0.004925682675093412,
0.007107227109372616,
0.009726360440254211,
0.017556138336658478,
0.0020221704617142677,
-0.02279089204967022,
-0.012506648898124695,
-0.006137666292488575,
-0.013363838195800781,
0.004211446736007929,
0.022178620100021362,
0.005693871062248945,
-0.020915692672133446,
-0.019418809562921524,
-0.008986052125692368,
0.013959743082523346,
0.007425797171890736,
-0.0019516721367835999,
0.005004162900149822,
0.010698176920413971,
0.00019662780687212944,
0.003293317276984453,
0.007741229608654976,
0.016210351139307022,
0.02051551267504692,
-0.0070110284723341465,
-0.012071739882230759,
0.010764327831566334,
0.014834238216280937,
-0.016590364277362823,
0.0020186337642371655,
0.008474732749164104,
0.007998427376151085,
-0.0011503743007779121,
0.004802917130291462,
0.01371077448129654,
-0.006024532951414585,
0.002519226400181651,
-0.003262975485995412,
0.0021885447204113007,
0.001054492313414812,
-0.003429998643696308,
0.010064356960356236,
0.00987466610968113,
0.007041001692414284,
0.011756457388401031,
-0.02748354896903038,
0.016527142375707626,
0.012911246158182621,
0.00156689016148448,
-0.004337387625128031,
0.007508694659918547,
0.007585969287902117,
0.01764834113419056,
0.012695089913904667,
0.02256195805966854,
-0.004623625427484512,
0.0189848430454731,
0.027570093050599098,
-0.010254902765154839,
0.007609223481267691,
0.0028707366436719894,
-0.007024919148534536,
-0.015833694487810135,
-0.0141923101618886,
0.007820975966751575,
0.02028103545308113,
-0.01242654025554657,
0.002191891660913825,
-0.01074217539280653,
-0.007240300066769123,
-0.004505150485783815,
-0.009145221672952175,
0.01831185631453991,
-0.007347092963755131,
0.00530842412263155,
-0.0041296398267149925,
-0.011206469498574734,
0.005187030415982008,
0.007045540027320385,
-0.023904208093881607,
0.012475389987230301,
-0.0026945227291435003,
-0.007743793539702892,
0.006730470806360245,
-0.008871215395629406,
0.01924845762550831,
0.016266444697976112,
0.0267692431807518,
-0.0135490782558918
] | [
0.19261395931243896,
-0.15606588125228882,
0.12079215049743652,
0.10323960334062576,
0.07709003239870071,
-0.05804818496108055,
0.2343328595161438,
-0.14076560735702515,
-0.2037646621465683,
-0.05971221625804901,
-0.6250205039978027,
0.5018411874771118,
-0.2912396192550659,
0.40600863099098206,
-0.5233753323554993,
0.4340883493423462,
0.3042426109313965,
-0.1960803121328354,
-0.11764755100011826,
-0.5848039388656616,
-0.22155645489692688,
-0.22016672790050507,
-0.02605743333697319,
-0.37634924054145813,
-0.18945221602916718,
-0.22722099721431732,
0.20644181966781616,
-0.3827625513076782,
-0.7725964188575745,
-0.022086912766098976,
-0.025842418894171715,
0.14749260246753693,
0.11485572159290314,
-0.17279188334941864,
0.057524487376213074,
0.1095682680606842,
-0.3489508330821991,
-0.10940317809581757,
0.12995629012584686,
0.10715419054031372,
0.17619365453720093,
-0.3435805141925812,
-0.08478500694036484,
0.15027543902397156,
-0.25108274817466736,
-0.5394293069839478,
-1.0770716667175293,
0.16312769055366516,
-0.46643367409706116,
-0.22677788138389587,
-0.6291032433509827,
0.3562636971473694,
0.3064190447330475,
0.36687353253364563,
-0.02881718799471855,
0.041118450462818146,
-0.30441662669181824,
-0.5650659799575806,
0.2493613362312317,
-0.5442314743995667,
0.45523202419281006,
-0.22051560878753662,
-0.7017709016799927,
0.45599523186683655,
-0.1740570217370987,
0.09638143330812454,
-0.07164459675550461,
-0.22798898816108704,
-0.926778256893158,
-0.4567510187625885,
0.15969303250312805,
-0.07761639356613159,
-0.3278706967830658,
0.02323777973651886,
0.2235681265592575,
0.13522395491600037,
0.2870975434780121,
-0.12166544049978256,
0.2594440281391144,
-0.09868612885475159,
-0.22171032428741455,
0.6468093395233154,
-0.18166670203208923,
-0.04770805314183235,
0.5556831359863281,
-0.12999020516872406,
-0.5192379951477051,
0.5719519257545471,
-0.4160543978214264,
-0.24959436058998108,
0.24375149607658386,
-0.010021927766501904,
-0.21384678781032562,
0.33049696683883667,
0.1378759890794754,
0.16688841581344604,
0.04861162602901459,
-0.27295348048210144,
0.13436856865882874,
0.3784499168395996,
-0.294763445854187,
0.004087237175554037,
0.49314239621162415,
-0.11406967788934708,
-0.08334920555353165,
-0.6472631692886353,
-0.05677705630660057,
-0.03449174761772156,
0.08397424966096878,
-0.004181612282991409,
-0.41550517082214355,
0.3697037696838379,
-0.14654679596424103,
0.11305101960897446,
-0.2533368766307831,
-0.06423310935497284,
-0.07516885548830032,
-0.02236858382821083,
-0.21689319610595703,
0.36834070086479187,
-0.28710147738456726,
1.4107930660247803,
0.42307063937187195,
0.19099730253219604,
-0.13439849019050598,
-0.11641041189432144,
0.3237149715423584,
0.30040454864501953,
-0.7814726829528809,
0.35210761427879333,
0.4372488260269165,
1.240459680557251,
-0.253447949886322,
-0.0065646846778690815,
-0.026212375611066818,
-0.06427141278982162,
0.3029242753982544,
0.11246763169765472,
0.6083908677101135,
0.2338375300168991,
-0.3398240804672241,
-0.18478578329086304,
-0.4916529953479767,
0.2911209464073181,
-0.20103688538074493,
-0.4733729362487793,
-0.264375239610672,
0.0018862815340980887,
-0.31484729051589966,
0.09569571167230606,
-0.005415963474661112,
-0.06785839051008224,
-0.1936676949262619,
-0.392120897769928,
-0.26490649580955505,
0.1804845780134201,
0.022759264335036278,
-0.19848483800888062,
-0.24659937620162964,
0.0853140577673912,
0.17026758193969727,
0.12381914258003235,
-0.6609283089637756,
-0.34376466274261475,
0.4605770707130432,
-0.6794707179069519,
0.3869878649711609,
0.5473073124885559,
0.08622459322214127,
-0.10018541663885117,
-0.25057655572891235,
-0.13084529340267181,
0.4844185411930084,
-0.7932562232017517,
0.11353740841150284,
0.42538803815841675,
0.2745908200740814,
-0.00513079110532999,
0.13046389818191528,
0.08371293544769287,
-0.8693314790725708,
0.10839080810546875,
0.23936980962753296,
-0.34976330399513245,
-0.40660926699638367,
0.10297780483961105,
0.5831775665283203,
-0.11887888610363007,
-0.34762951731681824,
0.11177025735378265,
-0.7971267104148865,
-0.3917364478111267,
0.557803213596344,
-0.6870521306991577,
0.9813343286514282,
0.286113440990448,
0.1182432621717453,
1.5769507884979248,
-0.41198885440826416,
0.25063520669937134,
-0.3877162039279938,
0.09993743896484375,
0.28492891788482666,
-0.2412707805633545,
-0.4977622926235199,
0.34126219153404236,
0.3739745020866394,
0.08079893887042999,
-0.20397156476974487,
-0.09733577072620392,
0.8126565217971802,
0.059818848967552185,
-0.19174322485923767,
0.061048660427331924,
0.07998228073120117,
0.26118728518486023,
-0.17838701605796814,
-0.3084263801574707,
-0.2516481876373291,
-0.4192010760307312,
0.26456359028816223,
-0.37641480565071106,
0.4763477146625519,
0.4528852105140686,
-0.045231763273477554,
0.7663344144821167,
0.2921544313430786,
0.5268710255622864,
0.7217053174972534,
-0.3102797269821167,
-0.15438516438007355,
-0.3537914454936981,
0.019355427473783493,
-0.2023034244775772,
-0.07747191935777664,
0.04304127022624016,
0.2019704431295395,
0.12045136094093323,
0.1689850091934204,
-0.050486382097005844,
-0.2817218005657196,
0.19654561579227448,
-0.19091477990150452,
-0.03617340698838234,
0.1756819635629654,
-0.07464651763439178,
-0.05430419370532036,
0.3869437873363495,
-0.6294143199920654,
0.041062626987695694,
0.20366732776165009,
0.41501209139823914,
0.014522029086947441,
-0.6584255695343018,
0.3550785481929779,
0.2072208970785141,
-0.09805019199848175,
-0.07042502611875534,
0.11785195022821426,
-0.06108478829264641,
-0.031180843710899353,
-0.022527843713760376,
-0.27251896262168884,
-0.3718085289001465,
-0.37837690114974976,
-0.48353978991508484,
-0.22000880539417267,
-0.2417101413011551,
0.7078884840011597,
0.5002856850624084,
0.14688584208488464,
0.17867305874824524,
-0.9144703149795532,
0.10546978563070297,
-0.8679304122924805,
-0.5657063722610474,
0.2067306935787201,
0.2517280876636505,
-0.3807249069213867,
-0.3947509825229645,
-0.2711070477962494,
0.15911786258220673,
0.5303286910057068,
-0.13197360932826996,
-0.4476596713066101,
-0.062088850885629654,
0.14418983459472656,
0.07972110062837601,
-0.3775327503681183,
-0.06850073486566544,
-0.28697654604911804,
0.578887939453125,
0.11083470284938812,
0.08658203482627869,
0.6675517559051514,
0.24517619609832764,
-0.15114185214042664,
-0.21936090290546417,
0.5955612063407898,
-0.17981579899787903,
-0.3841055631637573,
0.120030976831913,
0.09879482537508011,
-0.25227150321006775,
-0.24028746783733368,
0.20496314764022827,
-0.21410033106803894,
-0.0028726260643452406,
-6.094116687774658,
0.3785396218299866,
-0.5462579727172852,
-0.14498618245124817,
-0.06117095425724983,
0.22602593898773193,
0.7909910678863525,
0.1334182620048523,
0.022417450323700905,
-0.14441096782684326,
-0.07094550877809525,
0.2330656200647354,
0.10809558629989624,
0.47790491580963135,
0.10741201788187027,
-0.049942776560783386,
0.2690875232219696,
0.35103246569633484,
0.126618430018425,
0.22399459779262543,
0.692220151424408,
-0.30424603819847107,
0.31979647278785706,
0.26097485423088074,
-0.07761415094137192,
0.13284991681575775,
-0.7089852690696716,
0.46726393699645996,
-0.31902989745140076,
-0.2134396731853485,
0.04914074391126633,
-0.10607018321752548,
0.16551701724529266,
-0.18808583915233612,
-0.04394975304603577,
0.06168368086218834,
0.3257989287376404,
0.43922531604766846,
-0.03131760284304619,
-0.10454445332288742,
0.4117678105831146,
0.019855620339512825,
0.21169117093086243,
-0.45976775884628296,
0.017009312286973,
0.4510592818260193,
-0.0998053103685379,
-0.08589404821395874,
0.26332083344459534,
0.5973660945892334,
-0.04629482328891754,
-0.26392266154289246,
0.27595752477645874,
0.3794095516204834,
0.06493943184614182,
-0.46184042096138,
-0.008374582976102829,
0.1281336396932602,
-0.16048835217952728,
-0.08985614776611328,
-0.04092786833643913,
-0.37748923897743225,
-0.10058193653821945,
-1.048741340637207,
-0.2832176983356476,
0.0786929801106453,
-0.7137866020202637,
-0.3640962541103363,
0.8442386984825134,
0.5632763504981995,
-0.6410737633705139,
0.48312491178512573,
0.4942139685153961,
-0.4288564920425415,
0.4159794747829437,
-0.21826884150505066,
-0.40607115626335144,
-0.17026570439338684,
-0.3724810779094696,
0.34456735849380493,
-0.3289349675178528,
-0.3613879084587097,
0.4729629456996918,
-0.3934318423271179,
0.2311714142560959,
-0.4748186469078064,
-0.40029263496398926,
-0.38482028245925903,
-0.008473760448396206,
0.22701643407344818,
0.721774697303772,
-0.5507863759994507,
-0.10644714534282684,
-0.33656683564186096,
0.5651583671569824,
0.24750037491321564,
0.2663476765155792,
0.7205148339271545,
0.42551594972610474,
0.1103861927986145,
-0.013138188980519772,
-0.0748937800526619,
0.18870936334133148,
-0.8568262457847595,
0.2595265209674835,
-0.026953844353556633,
-0.7469026446342468,
0.3116968870162964,
0.30886003375053406,
-0.30357179045677185,
-0.1578862965106964,
0.4807158410549164,
-0.11795349419116974,
-0.3219952881336212,
-0.00034386490005999804,
0.17202110588550568,
0.004579595290124416,
-0.32756882905960083,
0.14830313622951508,
-0.5259763598442078,
0.10276509821414948,
0.03500997647643089,
-0.4524555504322052,
0.0604255273938179,
0.14664828777313232,
-0.42728376388549805,
0.0901588574051857,
0.6479013562202454,
0.11927546560764313,
0.2105993628501892,
0.20814825594425201,
0.16820450127124786,
-0.27103808522224426,
-0.012467927299439907,
0.3661302328109741,
-0.5263429284095764,
-0.4452199637889862,
0.4925437271595001,
-0.0931505486369133,
-0.34599560499191284,
0.4258127808570862,
-0.7121549844741821,
0.09901290386915207,
0.13836902379989624,
0.08902450650930405,
0.20740476250648499,
0.3979700803756714,
-0.1577872782945633,
-0.11773324012756348,
0.1327330470085144,
-0.023473357781767845,
-0.1199788898229599,
-0.05165742337703705,
-0.21601502597332,
0.14337369799613953,
0.1123763844370842,
0.47121870517730713,
0.099339559674263,
0.5888954997062683,
-0.3730352520942688,
-0.009376287460327148,
0.3212570250034332,
-0.7224246263504028,
-0.15277323126792908,
-0.20712104439735413,
0.20835399627685547,
-0.6111924052238464,
-0.3960813283920288,
0.0337931364774704,
0.18838897347450256,
-0.7655832767486572,
-0.027118859812617302,
-0.44937145709991455,
0.022237248718738556,
0.49798187613487244,
-0.1776282638311386,
0.44228971004486084,
-0.03712429106235504,
-0.2096220850944519,
0.015564131550490856,
-0.04096556827425957,
-0.4502529501914978,
0.19635245203971863,
0.22443269193172455,
0.5402239561080933,
-0.3526987135410309,
0.015130133368074894,
0.1438952088356018,
-0.7742884159088135,
-0.6353352665901184,
0.4583713412284851,
0.21598272025585175,
0.2690508961677551,
-0.23172099888324738,
0.2720084488391876,
-0.20601139962673187,
0.08966577053070068,
0.9700862765312195,
0.16381318867206573,
-0.1585429459810257,
0.2577248811721802,
-0.169645756483078,
0.1480174958705902,
0.49116578698158264,
0.37429314851760864,
-0.19874832034111023,
-0.16182348132133484,
-0.17244745790958405,
-0.02302573435008526,
0.10677766799926758,
-0.47710514068603516,
-0.6312786936759949,
0.1370379775762558,
0.32120877504348755,
0.020544348284602165,
-0.260041743516922,
0.366916298866272,
-0.1443057805299759,
-0.042814210057258606,
0.2649809718132019,
0.2779289782047272,
0.018996194005012512,
0.06694214046001434,
0.5533561110496521,
-0.21756435930728912,
0.03474880009889603,
0.020773040130734444,
-0.8770506978034973,
0.24542927742004395,
0.11812664568424225,
0.05266883596777916,
-0.45788079500198364,
0.36458688974380493,
0.1529228836297989,
-0.3424152135848999,
-0.6016695499420166,
-0.08034536242485046,
0.5626313090324402,
0.08971378207206726,
0.025758860632777214,
0.8003977537155151,
0.19183038175106049,
-0.18603162467479706,
0.08102325350046158,
-0.8501584529876709,
0.28162187337875366,
0.43149277567863464,
-0.4478566646575928,
-0.42715221643447876,
0.44114241003990173,
0.3711280822753906,
0.028228366747498512,
-0.035321906208992004,
0.1462504118680954,
0.7122382521629333,
0.2446938008069992,
-0.3455860912799835,
-0.385563462972641,
0.16377584636211395,
0.48163071274757385,
0.30909886956214905,
-0.27986419200897217,
0.11248607933521271,
-0.2090875655412674,
0.6367380023002625,
0.12534105777740479,
-0.02497258223593235,
-0.6175694465637207,
0.45134255290031433,
0.06637559831142426,
-0.3449365198612213,
-0.11651699244976044,
0.5126122832298279,
0.7098549604415894,
0.00785655714571476,
0.11430901288986206,
-0.1713276505470276,
0.15988488495349884,
-0.41317084431648254,
0.004783074837177992,
-0.34233352541923523,
-0.4538671374320984,
-0.02320977859199047,
-0.24828170239925385,
0.02160530537366867,
-0.2779293358325958,
0.7998630404472351,
0.011288299225270748,
-0.07665321230888367,
-0.28014278411865234,
-0.5794170498847961,
0.5057218074798584,
-0.5067156553268433,
-0.08141052722930908,
-0.22444455325603485,
-0.29792091250419617,
0.06905514001846313,
0.39687392115592957,
-0.3949351906776428,
-0.4037091135978699,
-0.4285346269607544,
-0.16505400836467743,
0.5563362836837769,
-1.0199954509735107,
0.5727972388267517,
0.16983027756214142,
0.2549218535423279,
0.5546615719795227,
-0.22677738964557648,
0.2840196192264557,
0.2050255388021469,
0.3915473222732544,
0.30907583236694336,
0.5518319010734558,
0.009490828961133957,
-0.5117775201797485,
-0.20994150638580322,
-0.17318515479564667,
0.5323162078857422,
0.049773238599300385,
0.09603305160999298,
0.4386615753173828,
0.17621730268001556,
-0.40086689591407776,
-0.4938691258430481,
0.44079694151878357,
0.29488182067871094,
0.040056921541690826,
-0.06007258966565132,
0.20877324044704437,
0.42677801847457886,
0.3092804253101349,
0.17405319213867188,
0.29361864924430847,
-0.13861599564552307,
-0.15755389630794525,
0.10609723627567291,
-0.11181681603193283,
0.029477771371603012,
0.1843125969171524,
0.4080117344856262,
0.3640954792499542,
-0.5170939564704895,
0.3491772413253784,
0.26273834705352783,
0.23805755376815796,
0.3764682710170746,
0.4054083824157715,
0.12156692892313004,
0.16466878354549408,
0.16202707588672638,
-0.31375792622566223,
0.11563970148563385,
-0.01978893205523491,
-0.17731517553329468,
-0.3631630837917328,
0.34282299876213074,
-0.2433435022830963,
0.07418213784694672,
-0.015022004954516888,
0.0492081455886364,
0.587604820728302,
-0.6202042698860168,
-0.09358058124780655,
0.2749673128128052,
-0.558795154094696,
0.9138160347938538,
-0.0555930994451046,
0.15899346768856049,
-0.14222317934036255,
0.30679935216903687,
0.3149471879005432,
-0.13999679684638977,
0.138116717338562,
-0.047947343438863754,
-0.7125722765922546,
0.5776903629302979,
0.3169492483139038,
0.03198036551475525,
0.0342898815870285,
0.2721186578273773,
-0.24651695787906647,
0.09590227156877518,
-0.4054311513900757,
0.3792498707771301,
-0.1276334524154663,
0.17872871458530426,
-0.19688302278518677,
-0.05389944091439247,
-0.20441995561122894,
-0.20932559669017792,
-1.18461012840271,
-0.4523583650588989,
0.1695995330810547,
-0.08333763480186462,
-0.5104238986968994,
-0.08662228286266327,
0.552756667137146,
0.45944398641586304,
0.3395689129829407,
-0.02665170095860958,
0.3716173470020294,
-0.05449163168668747,
0.43708163499832153,
-0.735430121421814,
0.5390613675117493,
-0.20033644139766693,
-0.14062783122062683,
-0.8184773325920105,
0.18290488421916962,
1.0319435596466064,
0.5449687838554382,
-0.056340135633945465,
0.23044216632843018,
0.15747569501399994,
-0.6325528025627136,
-0.10367169976234436,
-0.6033763885498047,
0.4381173551082611,
-0.2615424692630768,
0.19382330775260925,
-0.2977551221847534,
0.5550985336303711,
-0.1612001359462738,
-0.34748947620391846,
-0.1349601149559021,
0.4299413561820984,
0.439882755279541,
-0.5278176069259644,
0.2475716769695282,
-0.394390732049942,
-0.19623644649982452,
-0.4949623942375183,
0.6581477522850037,
-0.3632447421550751,
0.21943239867687225,
-0.2629651725292206,
0.05258132889866829,
0.04035789892077446,
-0.5387517809867859,
0.08314350992441177,
0.18377482891082764,
0.027910955250263214,
-0.09773433208465576,
0.04617083817720413,
0.40003594756126404,
-0.22064492106437683,
-0.061775632202625275,
-0.6427918672561646,
0.38047856092453003,
0.011883719824254513,
0.008591425605118275,
-0.1842663735151291,
-0.013435270637273788,
0.14526459574699402,
-0.6116735339164734,
-0.28213396668434143,
0.1548415869474411,
-0.3159583806991577,
-0.1400616616010666
] |
Large collections of protein-encoding open reading frames (ORFs) established in a versatile recombination-based cloning system have been instrumental to study protein functions in high-throughput assays. Such ‘ORFeome’ resources have been developed for several organisms but in virology, plasmid collections covering a significant fraction of the virosphere are still needed. In this perspective, we present ViralORFeome 1.0 (http://www.viralorfeome.com), an open-access database and management system that provides an integrated set of bioinformatic tools to clone viral ORFs in the Gateway® system. ViralORFeome provides a convenient interface to navigate through virus genome sequences, to design ORF-specific cloning primers, to validate the sequence of generated constructs and to browse established collections of virus ORFs. Most importantly, ViralORFeome has been designed to manage all possible variants or mutants of a given ORF so that the cloning procedure can be applied to any emerging virus strain. A subset of plasmid constructs generated with ViralORFeome platform has been tested with success for heterologous protein expression in different expression systems at proteome scale. ViralORFeome should provide our community with a framework to establish a large collection of virus ORF clones, an instrumental resource to determine functions, activities and binding partners of viral proteins. | [
-0.003931785002350807,
0.028935499489307404,
-0.0032559221144765615,
0.008271913975477219,
0.009586259722709656,
-0.02563505806028843,
0.010432460345327854,
0.01048535667359829,
-0.007412681821733713,
0.0231744647026062,
-0.004193439614027739,
0.015001468360424042,
0.005634566303342581,
0.009705830365419388,
-0.0012296903878450394,
-0.017428869381546974,
-0.012974150478839874,
0.0030440816190093756,
0.011524861678481102,
-0.015751391649246216,
0.022446196526288986,
-0.019448211416602135,
0.00875886995345354,
0.015339968726038933,
-0.005576382391154766,
0.020018666982650757,
0.009766243398189545,
-0.00846901722252369,
0.010437987744808197,
-0.010675691068172455,
-0.009855055250227451,
-0.031868889927864075,
-0.007750585209578276,
0.02702859416604042,
0.001799028948880732,
0.008222733624279499,
-0.01096162386238575,
0.01969940774142742,
0.03448871895670891,
-0.005526324268430471,
-0.001329351682215929,
-0.005707959178835154,
0.00901809148490429,
-0.011278748512268066,
-0.010303903371095657,
-0.02122107520699501,
-0.006537741050124168,
0.013486932031810284,
-0.009737768210470676,
0.009186615236103535,
-0.011616772972047329,
-0.0068484521470963955,
-0.00789258535951376,
0.02778347209095955,
-0.00572021072730422,
0.02437027543783188,
0.017446834594011307,
-0.004378127865493298,
0.007518899627029896,
0.003011023625731468,
0.020541910082101822,
0.000679019489325583,
0.011132153682410717,
-0.016431881114840508,
0.004632851108908653,
-0.06702646613121033,
0.0033122412860393524,
0.012545598670840263,
0.009349331259727478,
0.012368055060505867,
0.008246696554124355,
0.010605959221720695,
-0.006213735323399305,
0.003638402558863163,
-0.008955511264503002,
-0.0131969740614295,
0.011504365131258965,
0.004840250127017498,
0.018440168350934982,
-0.004312142729759216,
-0.0026215980760753155,
0.007656091824173927,
-0.015162762254476547,
0.003974790684878826,
-0.0028319070115685463,
0.0019324148306623101,
-0.029353298246860504,
0.023268748074769974,
-0.025582490488886833,
0.013741331174969673,
0.0039660013280808926,
-0.031916484236717224,
-0.03225534036755562,
0.033980343490839005,
-0.019711874425411224,
0.028614040464162827,
0.013385366648435593,
-0.01019136793911457,
-0.005342256743460894,
-0.018798625096678734,
-0.022837288677692413,
0.01893770508468151,
0.01971651241183281,
-0.0018522676546126604,
0.025956157594919205,
0.012872252613306046,
0.024069659411907196,
0.00707940012216568,
0.021180134266614914,
0.009279996156692505,
-0.002801827620714903,
-0.02766665443778038,
-0.00882050208747387,
0.006183241028338671,
0.006933911237865686,
-0.0015106964856386185,
-0.002075245138257742,
0.018077801913022995,
0.006902656517922878,
-0.02084844931960106,
0.0016810065135359764,
0.0032429047860205173,
0.014663111418485641,
-0.013356277719140053,
0.01151371095329523,
-0.029831387102603912,
-0.0021578576415777206,
-0.024129144847393036,
0.0164884515106678,
-0.02056715451180935,
-0.01051241159439087,
0.006794588174670935,
-0.004016294609755278,
-0.058420002460479736,
0.016873998567461967,
-0.0014999930281192064,
0.006356595084071159,
-0.034247010946273804,
0.005275235045701265,
-0.01479516550898552,
0.0177846048027277,
0.0047926027327775955,
0.0058773173950612545,
0.011950559914112091,
-0.0056550693698227406,
0.000009683426469564438,
-0.03931770473718643,
0.004735027439892292,
0.013252821750938892,
-0.017449714243412018,
0.007158536929637194,
0.00044506858102977276,
-0.02798020839691162,
-0.012218172661960125,
-0.004571915604174137,
-0.015693683177232742,
-0.026331521570682526,
-0.01411699503660202,
-0.0009162626229226589,
-0.0011576837860047817,
0.02337384968996048,
0.019457809627056122,
0.00560589786618948,
0.007955275475978851,
0.008201384916901588,
0.013279512524604797,
0.010820649564266205,
0.004440972115844488,
0.009101428091526031,
0.004709040280431509,
0.0014304954092949629,
0.008036212995648384,
0.015720218420028687,
0.006391961593180895,
0.028945818543434143,
-0.00447702594101429,
0.015146223828196526,
0.0062157344073057175,
-0.014759178273379803,
0.0668322741985321,
-0.0159139521420002,
0.03194514662027359,
-0.003152867779135704,
0.0095704710111022,
-0.009077866561710835,
-0.011823149397969246,
0.03186652064323425,
-0.017339982092380524,
0.024664994329214096,
-0.0006112775299698114,
0.011989323422312737,
-0.02730618603527546,
0.005974847823381424,
0.002474850509315729,
0.03761500492691994,
0.0017122883582487702,
0.0013014532160013914,
0.00587180070579052,
0.0003223484382033348,
-0.0035186964087188244,
-0.004261638969182968,
-0.006794644519686699,
0.006057641934603453,
0.0010467711836099625,
-0.008980012498795986,
0.007994934916496277,
-0.009746218100190163,
-0.016203664243221283,
0.010957937687635422,
0.005026227794587612,
0.00792968925088644,
0.008435357362031937,
0.007630952168256044,
-0.025217710062861443,
0.03927849233150482,
-0.006661940831691027,
-0.012206753715872765,
-0.0357695035636425,
0.011145290918648243,
-0.014270445331931114,
-0.008860280737280846,
-0.007587588857859373,
-0.029837828129529953,
-0.008080845698714256,
-0.0014790729619562626,
0.036932606250047684,
-0.012903684750199318,
0.012572185136377811,
-0.02068978361785412,
0.006580369547009468,
0.01047122199088335,
-0.012619944289326668,
-0.010988453403115273,
-0.007698274217545986,
0.015095118433237076,
0.008671646006405354,
0.009792846627533436,
-0.00823638029396534,
-0.001997843151912093,
-0.009330479428172112,
-0.006683457177132368,
0.002672031056135893,
0.012279368005692959,
-0.03779447823762894,
-0.015618342906236649,
-0.021683797240257263,
0.02875474840402603,
-0.019428648054599762,
-0.01995379850268364,
-0.010076725855469704,
0.0017482626717537642,
0.054796554148197174,
0.014551318250596523,
0.003370663383975625,
0.007641506381332874,
0.025190096348524094,
0.008200544863939285,
0.0038306210190057755,
0.024039223790168762,
-0.005484815686941147,
-0.0023227082565426826,
0.009561847895383835,
0.007313170935958624,
-0.005048385355621576,
-0.00168217858299613,
-0.0016553131863474846,
-0.012183615937829018,
0.0014354283921420574,
0.0040587373077869415,
-0.007160293869674206,
0.006092296913266182,
-0.009195858612656593,
0.00471501937136054,
-0.08142156898975372,
-0.0149955153465271,
-0.003648539073765278,
0.013805260881781578,
0.007877077907323837,
-0.006561116315424442,
0.006084798835217953,
-0.017768312245607376,
-0.008751166984438896,
0.002875349950045347,
0.01774616539478302,
0.019260086119174957,
-0.01879945397377014,
-0.010400701314210892,
0.007338524796068668,
-0.015625279396772385,
0.01520755048841238,
0.017325207591056824,
-0.02378401719033718,
-0.01250442210584879,
-0.04332195222377777,
0.010326661169528961,
0.015264621935784817,
-0.008544087409973145,
-0.05932854488492012,
-0.009513054974377155,
0.008503266610205173,
-0.0021534208208322525,
-0.011776016093790531,
0.0030719798523932695,
0.006651042029261589,
-0.01479190681129694,
0.024679377675056458,
-0.012216398492455482,
0.034500978887081146,
0.009588142856955528,
-0.0023399952333420515,
-0.02212589792907238,
-0.0081801638007164,
0.020287465304136276,
-0.008778629824519157,
0.013909917324781418,
-0.008733055554330349,
-0.0014652613317593932,
0.006674921605736017,
-0.0010151569731533527,
0.015537822619080544,
0.02394404448568821,
0.012368403375148773,
0.021533891558647156,
0.010418131947517395,
-0.016212642192840576,
0.00973899383097887,
0.01385408639907837,
-0.005242123268544674,
0.01588474214076996,
-0.041056565940380096,
-0.007784973364323378,
-0.013019227422773838,
-0.007737049832940102,
-0.006564954295754433,
-0.034507449716329575,
0.019323598593473434,
-0.01728866994380951,
-0.005858703516423702,
0.0032648262567818165,
0.01710772141814232,
-0.00604777317494154,
0.004822771064937115,
0.02960909903049469,
-0.009684395976364613,
-0.002994765294715762,
0.0000076212454587221146,
-0.0019233032362535596,
0.013969101943075657,
-0.013758627697825432,
-0.016552254557609558,
0.0007383152842521667,
0.013484455645084381,
-0.0015010017668828368,
-0.026379169896245003,
-0.000224946066737175,
-0.016073521226644516,
0.007348014973104,
-0.026667147874832153,
-0.008250225335359573,
0.014380245469510555,
-0.011080550029873848,
-0.002033493248745799,
-0.008205653168261051,
0.030670056119561195,
0.015282798558473587,
-0.01251688227057457,
0.006867730058729649,
-0.013726890087127686,
-0.004595993086695671,
0.0038809035904705524,
-0.0035552578046917915,
0.010961073450744152,
0.008838064968585968,
-0.01618890091776848,
-0.0006908011273480952,
0.025073789060115814,
-0.017716053873300552,
-0.001843934180215001,
0.014920946210622787,
-0.012471689842641354,
0.006646181456744671,
0.003632000181823969,
-0.004321596585214138,
-0.026261070743203163,
-0.02363630384206772,
-0.010368715971708298,
0.007948620244860649,
0.009364031255245209,
-0.018918471410870552,
-0.027815094217658043,
-0.02132437378168106,
0.07235566526651382,
0.022046782076358795,
0.0019914894364774227,
-0.005485007539391518,
-0.001976099330931902,
-0.030003570020198822,
0.0001522577367722988,
-0.0016699014231562614,
0.041901685297489166,
-0.014757269993424416,
0.01168522797524929,
-0.009887363761663437,
-0.00870338175445795,
-0.05344749987125397,
0.012534623965620995,
-0.003300630021840334,
-0.020282918587327003,
-0.028280287981033325,
0.00014738598838448524,
0.01957637444138527,
-0.01342797838151455,
0.006952266208827496,
0.0035264180041849613,
-0.019034143537282944,
0.007636167109012604,
-0.019578438252210617,
-0.007815889082849026,
-0.012282177805900574,
0.003996918443590403,
0.011567085050046444,
0.018296653404831886,
-0.0029193595983088017,
-0.011796379461884499,
-0.01906508021056652,
0.010334275662899017,
-0.00547427125275135,
-0.004333209712058306,
0.02627922035753727,
0.0018878438277170062,
-0.007553825154900551,
0.001208561472594738,
-0.014594968408346176,
0.00291060796007514,
0.012335363775491714,
0.0010951496660709381,
-0.01919865794479847,
0.028835877776145935,
-0.009886834770441055,
-0.0011828322894871235,
0.0077259475365281105,
-0.006001538597047329,
0.024499718099832535,
0.015693340450525284,
0.012189064174890518,
0.01122877188026905,
-0.02706778049468994,
0.025768019258975983,
-0.002552029909566045,
-0.019249113276600838,
0.01257910393178463,
-0.0019026095978915691,
0.025937654078006744,
0.0062300777062773705,
-0.012136084958910942,
0.00030612247064709663,
-0.010040675289928913,
-0.008373960852622986,
0.0055276816710829735,
0.0440322645008564,
0.016228217631578445,
0.010870503261685371,
0.010421567596495152,
-0.02138441428542137,
-0.030261993408203125,
0.007903278805315495,
-0.03584199398756027,
0.009444428607821465,
0.027893226593732834,
0.013004585169255733,
-0.010107200592756271,
0.0047132838517427444,
0.02667076885700226,
0.03649020195007324,
-0.02330533042550087,
0.01468842476606369,
-0.02194427326321602,
-0.01284883078187704,
-0.0747905969619751,
0.006436311639845371,
0.0005184998735785484,
-0.0035676853731274605,
0.018287373706698418,
0.008687295950949192,
-0.004186462145298719,
-0.036377470940351486,
-0.002841017907485366,
0.0059005217626690865,
0.023143962025642395,
0.0007267617620527744,
0.015321023762226105,
-0.011250581592321396,
0.008043664507567883,
0.04067099466919899,
-0.002267424948513508,
-0.005475137382745743,
0.009540383704006672,
0.009687645360827446,
0.04069835692644119,
-0.010624018497765064,
0.0313081219792366,
0.0009607617976143956,
-0.007987815886735916,
-0.08157508075237274,
0.0046208081766963005,
-0.0003729849122464657,
-0.01317543163895607,
0.015494726598262787,
-0.0023396178148686886,
0.017218703404068947,
-0.023788589984178543,
0.026762044057250023,
-0.013180909678339958,
-0.028699979186058044,
-0.015861574560403824,
-0.024519262835383415,
0.006167401559650898,
-0.0028033661656081676,
-0.012537091970443726,
0.006454715505242348,
0.040130481123924255,
0.004615856800228357,
0.015426600351929665,
-0.027587473392486572,
0.02949310839176178,
-0.008432427421212196,
0.018157437443733215,
-0.00926500279456377,
0.013446033000946045,
-0.02607477456331253,
0.008455280214548111,
0.02766198106110096,
0.004108178894966841,
0.006034140475094318,
0.007949300110340118,
-0.003262853715568781,
0.00009698374196887016,
-0.0017243302427232265,
-0.017431430518627167,
0.017918109893798828,
-0.01212269626557827,
-0.008627507835626602,
-0.005969579331576824,
0.00014747673412784934,
0.00036946660839021206,
0.013900501653552055,
0.00570859108120203,
0.003535760333761573,
-0.013864033855497837,
0.00794176198542118,
-0.00779615668579936,
0.015681564807891846,
-0.006780588999390602,
0.004945508204400539,
-0.024246342480182648,
-0.004727651365101337,
0.0155371418222785,
-0.005806467961519957,
-0.01063545048236847,
-0.003701654961332679,
0.004805324133485556,
0.006621183827519417,
0.015270106494426727,
-0.0027150395326316357,
0.01419602520763874,
-0.006090836599469185,
0.07177083939313889,
-0.014498676173388958,
0.021497584879398346,
0.010605710558593273,
0.003375957254320383,
0.007820437662303448,
-0.011475857347249985,
-0.005639003124088049,
0.011498218402266502,
-0.016852593049407005,
0.00968438945710659,
-0.0036660025361925364,
-0.010593809187412262,
0.014022979885339737,
0.0175732783973217,
-0.01416479516774416,
0.000029276590794324875,
0.003165862523019314,
-0.0061110518872737885,
0.012473627924919128,
-0.021138789132237434,
0.03490597754716873,
0.009403345175087452,
0.0024777334183454514,
0.02790042944252491,
0.0037493212148547173,
0.008675915189087391,
0.01406685821712017,
-0.0030592612456530333,
-0.011882289312779903,
-0.011359162628650665,
-0.004061248619109392,
0.00447480846196413,
-0.001552713569253683,
0.019571775570511818,
-0.016866829246282578,
0.008083917200565338,
0.0074728066101670265,
0.0029312665574252605,
0.007482412736862898,
-0.034105926752090454,
0.00540345162153244,
-0.0037161381915211678,
0.012023800984025002,
0.042901016771793365,
-0.031800784170627594,
0.007826062850654125,
0.027839841321110725,
-0.004731649532914162,
0.005801419727504253,
-0.009015471674501896,
0.0043545872904360294,
0.00878429226577282,
-0.01717706397175789,
0.0007249182090163231,
0.013365397229790688,
-0.003739305306226015,
0.011025122366845608,
-0.014097263105213642,
0.013387947343289852,
-0.01325107179582119,
-0.005895603448152542,
0.01279359683394432,
-0.007219195365905762,
0.017925400286912918,
-0.022754691541194916,
0.001429493073374033,
-0.018195874989032745,
-0.032599180936813354,
0.015100612305104733,
-0.017234928905963898,
-0.00010251509957015514,
0.005953644867986441,
-0.006914726458489895,
0.008393540047109127,
0.017222309485077858,
0.0057622636668384075,
0.01590743660926819,
0.00962451659142971,
0.018792465329170227,
-0.00957320537418127,
0.016389138996601105,
-0.005733994301408529,
0.007931136526167393,
-0.012021729722619057,
0.022806141525506973,
-0.012170117348432541,
-0.022005515173077583,
-0.00030569470254704356,
0.01033239159733057,
0.024556908756494522,
0.0012928484939038754,
0.002351465169340372,
0.017056100070476532,
0.005136033520102501,
0.03379207104444504,
-0.020566197112202644,
0.00713188573718071,
-0.011258377693593502,
0.005772629287093878,
0.010801656171679497,
0.023821843788027763,
-0.005419688764959574,
0.015270397998392582,
-0.0036041662096977234,
0.004394124262034893,
0.026671243831515312,
-0.005429800599813461,
0.021143142133951187,
-0.005613627377897501,
0.0014251288957893848,
-0.0030319374054670334,
-0.012863078154623508,
-0.00875385943800211,
0.008584883064031601,
0.012298894114792347,
-0.009450049139559269,
-0.011315524578094482,
-0.006094461306929588,
-0.01562749221920967,
0.009404183365404606,
-0.006773633882403374,
0.007960688322782516,
-0.0009725457057356834,
0.03748128563165665,
-0.003689342178404331,
-0.007272113114595413,
0.0002890781033784151,
0.013590688817203045,
-0.02034059539437294,
0.017036449164152145,
-0.015684401616454124,
-0.01013302430510521,
0.024307645857334137,
-0.0011139621492475271,
-0.033157993108034134,
0.01778082177042961,
-0.014647521078586578,
-0.016306482255458832,
-0.032686419785022736,
-0.007948825135827065,
-0.009062087163329124,
0.006241376977413893,
-0.013564379885792732,
0.006434065289795399,
0.013327520340681076,
0.011959431692957878,
0.0068426597863435745,
0.006691888440400362,
0.02344771847128868,
0.005312478169798851,
-0.011073902249336243,
-0.017601260915398598,
-0.003281624987721443,
0.014987083151936531,
0.016784735023975372,
0.0017570118652656674,
0.005501944571733475,
-0.005483326502144337,
0.004205498844385147,
0.00002966448664665222,
0.03797200322151184,
0.01723010465502739,
0.007054632063955069,
0.00775692006573081,
0.019535783678293228,
0.0033467235043644905,
0.005310565233230591,
-0.00670936144888401,
0.025450963526964188,
0.025019647553563118,
-0.03254654258489609,
0.0037630414590239525,
0.0037295976653695107,
-0.027143124490976334,
-0.011950246058404446,
-0.013950077816843987,
-0.003630193881690502,
0.008658848702907562,
0.0023982517886906862,
-0.01137967687100172,
0.025721587240695953,
0.01234360784292221,
-0.01132920477539301,
0.008067905902862549,
-0.0012494325637817383,
-0.004497125744819641,
0.01833658665418625,
-0.008212192915380001,
0.0012223501689732075,
0.0013607748551294208,
0.01951896771788597,
-0.01858295500278473,
0.011188465170562267,
0.010915958322584629,
-0.010808959603309631,
-0.0015689947176724672,
-0.001409275340847671,
-0.0008364469977095723,
0.006792799569666386,
0.0016293359221890569,
-0.011304469779133797
] | [
0.41753315925598145,
0.10249704122543335,
0.05494013428688049,
0.05186887085437775,
0.027343513444066048,
0.04635867476463318,
0.013813351280987263,
-0.043129194527864456,
-0.5207227468490601,
-0.6414918899536133,
-0.011571484617888927,
-0.26263049244880676,
-0.4680289328098297,
0.7109658122062683,
-0.0593162402510643,
0.5275841951370239,
0.1789221316576004,
0.46877315640449524,
-0.10343551635742188,
0.040551453828811646,
-0.5728373527526855,
-0.2082338184118271,
0.4345758855342865,
-0.13458037376403809,
-0.25571587681770325,
-0.07180710136890411,
0.4683874547481537,
-0.08968112617731094,
0.23338785767555237,
-0.1454220414161682,
-0.0650520920753479,
0.1969214826822281,
0.10557157546281815,
0.12907366454601288,
-0.11121536791324615,
-0.5924153923988342,
-0.45433634519577026,
0.1999112218618393,
0.17455464601516724,
-0.3988616466522217,
-0.19719743728637695,
-0.47223100066185,
-0.1970604956150055,
0.3408624231815338,
-0.15663430094718933,
-0.7323276400566101,
-1.3999956846237183,
0.4802264869213104,
-0.27439945936203003,
0.35214024782180786,
-0.3462747633457184,
0.13348601758480072,
0.5952286124229431,
0.04948261380195618,
0.2121371179819107,
0.10702411830425262,
-0.35446450114250183,
-0.2528139650821686,
0.3312638998031616,
-0.1605389416217804,
0.13646399974822998,
-0.046619851142168045,
0.08007747679948807,
0.2697426676750183,
-0.19142693281173706,
0.23876838386058807,
0.18767811357975006,
-0.0653507187962532,
-0.5504468679428101,
-0.17368528246879578,
0.2822314500808716,
-0.636951208114624,
-0.028036488220095634,
0.2308095544576645,
0.20819295942783356,
-0.3695635497570038,
0.10096337646245956,
0.046109262853860855,
0.3034575581550598,
0.045548949390649796,
-0.21656186878681183,
0.4691227972507477,
-0.285982608795166,
0.1269301474094391,
0.6241804361343384,
0.35886743664741516,
-0.5909743309020996,
0.45279332995414734,
-0.6770123839378357,
-0.05928725004196167,
0.23885442316532135,
0.18679581582546234,
0.2314733862876892,
0.23616814613342285,
0.4569430947303772,
0.1161985993385315,
-0.3533007800579071,
-0.10172116756439209,
0.22620566189289093,
0.543812096118927,
-0.47425851225852966,
-0.2989014685153961,
0.20627839863300323,
-0.47022876143455505,
-0.32889237999916077,
0.15684400498867035,
-0.2936994135379791,
-0.5012503862380981,
-0.2599407136440277,
-0.03989234194159508,
-0.19827449321746826,
-0.05729994177818298,
-0.4153780937194824,
0.006846449337899685,
-0.0883898213505745,
0.055990759283304214,
0.4281720221042633,
-0.5915282368659973,
-0.011064768768846989,
-0.028758801519870758,
-0.5662213563919067,
1.3889098167419434,
-0.036243364214897156,
0.0704333633184433,
-0.14553004503250122,
-0.0451485849916935,
0.2582069933414459,
0.16042067110538483,
-0.32214030623435974,
0.4218561351299286,
0.17331014573574066,
1.0379631519317627,
-0.041231077164411545,
-0.14620795845985413,
0.04328814893960953,
0.0019365774933248758,
-0.12541772425174713,
0.16184985637664795,
0.16638833284378052,
-0.3703332841396332,
-0.7388083338737488,
-0.6558619737625122,
-0.13875271379947662,
0.19077268242835999,
0.04452330991625786,
-0.12351582199335098,
-0.6317169070243835,
-0.2493697702884674,
-0.853297770023346,
-0.26874643564224243,
-0.35957103967666626,
-0.20670662820339203,
-0.4144359827041626,
0.05736202746629715,
-0.07875046133995056,
0.5453857779502869,
0.2434777021408081,
-0.1288880705833435,
0.23321957886219025,
0.2871895432472229,
0.46218621730804443,
0.12536726891994476,
-0.7282680869102478,
-0.5411116480827332,
-0.019359344616532326,
-0.246877059340477,
0.5684987902641296,
0.5819743871688843,
-0.06229708716273308,
-0.0796748697757721,
0.15648747980594635,
-0.24866220355033875,
0.14956577122211456,
-0.16912882030010223,
-0.07840780913829803,
-0.07630069553852081,
0.41151174902915955,
-0.20469358563423157,
0.15872147679328918,
0.15484341979026794,
-0.6216034293174744,
-0.22905483841896057,
0.3817988336086273,
-0.4274083077907562,
-0.030164316296577454,
0.2058480978012085,
0.433566153049469,
0.34548941254615784,
-0.17442426085472107,
0.20066213607788086,
-0.5639582276344299,
-0.00147606513928622,
0.22233286499977112,
-0.6716997027397156,
1.5589916706085205,
0.019245963543653488,
0.019352883100509644,
1.2842687368392944,
-0.07257593423128128,
-0.1251235157251358,
-0.2355644702911377,
0.3575211465358734,
0.1966685950756073,
-0.6492331027984619,
-0.5607199668884277,
-0.16075393557548523,
0.12716588377952576,
-0.1765333116054535,
-0.20773455500602722,
-0.2803080379962921,
0.805642306804657,
-0.43476027250289917,
0.47328391671180725,
-0.535355806350708,
0.19986076653003693,
0.0707344338297844,
0.12081902474164963,
0.2987655997276306,
-0.2894066274166107,
-0.05810441076755524,
1.1653735637664795,
-0.8413500189781189,
0.4558115303516388,
0.5775781273841858,
-0.2538328468799591,
0.5274875164031982,
0.7144125699996948,
0.11468760669231415,
0.7436838746070862,
-0.22243645787239075,
0.4008655846118927,
-0.6113338470458984,
0.39919760823249817,
-0.47386401891708374,
0.012410036288201809,
-0.07587268203496933,
0.009545856155455112,
0.2305925339460373,
0.08733966946601868,
0.16518442332744598,
0.20139460265636444,
0.6582749485969543,
-0.6924204230308533,
-0.22423182427883148,
0.2659531831741333,
-0.6769845485687256,
-0.12113647907972336,
-0.08530926704406738,
-0.42766356468200684,
-0.35996896028518677,
0.2665072977542877,
0.3871150314807892,
0.38168323040008545,
-0.517985463142395,
0.6388536095619202,
0.3431319296360016,
0.040691353380680084,
-0.17265796661376953,
-0.12537796795368195,
0.25274229049682617,
-0.37323927879333496,
-0.23291464149951935,
-0.0763535425066948,
0.16011394560337067,
-0.06775779277086258,
-0.11903708428144455,
0.022138478234410286,
-0.9741432070732117,
0.6555362343788147,
0.6606752872467041,
0.6087045073509216,
0.3256632685661316,
-0.6827938556671143,
0.27861258387565613,
0.2663567364215851,
-0.6715962290763855,
0.42881280183792114,
0.28778427839279175,
-0.12733960151672363,
-0.5072718262672424,
-0.3288121223449707,
0.3207044303417206,
0.9450019598007202,
-0.5319610238075256,
-0.2396061271429062,
-0.5805824398994446,
0.11474631726741791,
0.07358801364898682,
-0.49108079075813293,
-0.05155346170067787,
-0.312219500541687,
0.7239887118339539,
-0.11199771612882614,
-0.14037832617759705,
0.17688331007957458,
0.6763359308242798,
-0.03292788192629814,
0.3095598518848419,
0.5369001030921936,
0.003403617534786463,
-0.528512716293335,
-0.08073269575834274,
-0.03938636928796768,
-0.29514139890670776,
-0.10506416112184525,
0.09585055708885193,
-0.026816459372639656,
0.0358249768614769,
-5.833104133605957,
0.17588908970355988,
-0.43959110975265503,
-0.22793760895729065,
-0.16619454324245453,
-0.07206728309392929,
0.7704196572303772,
-0.21451790630817413,
0.5938037633895874,
-0.3725517690181732,
0.5224761962890625,
0.5766218304634094,
0.07428372651338577,
-0.1658424288034439,
0.2312784343957901,
0.6235811114311218,
0.40052521228790283,
0.4979744255542755,
0.44449082016944885,
-0.06448224186897278,
0.37612876296043396,
-0.005814981646835804,
-0.02539457380771637,
0.4496745765209198,
0.007139680441468954,
0.10452913492918015,
-1.3119564056396484,
0.3689188063144684,
0.03315778449177742,
0.1433258205652237,
0.18857938051223755,
-0.6245977878570557,
-0.24787083268165588,
-0.7642177939414978,
0.024452369660139084,
0.24499528110027313,
0.1862470954656601,
0.1065877377986908,
-0.006823993753641844,
-0.3865494728088379,
0.8511770367622375,
0.3741627335548401,
-0.22255711257457733,
-0.19765473902225494,
-0.005393448751419783,
-0.4459986984729767,
-0.3520740866661072,
0.27718791365623474,
0.07610471546649933,
0.7190393209457397,
-0.25295907258987427,
-0.25346511602401733,
0.6487333178520203,
0.36420056223869324,
0.2881231904029846,
-0.46434640884399414,
0.21050456166267395,
0.42442604899406433,
-0.2718692421913147,
-0.21399171650409698,
0.0034272850025445223,
-0.3017459809780121,
-0.16603916883468628,
-0.619392991065979,
-0.058037497103214264,
-0.17056705057621002,
-0.6167694330215454,
-0.10057006031274796,
0.10421212017536163,
0.1487886905670166,
-0.639596700668335,
0.4332951307296753,
0.1772734522819519,
-0.3855336010456085,
0.6863312125205994,
-0.315749853849411,
0.18175283074378967,
-0.08637332916259766,
-0.5803283452987671,
-0.021405622363090515,
-0.6053575277328491,
-0.08480866253376007,
-0.2034156173467636,
-0.05985249578952789,
0.27269095182418823,
-0.6501623392105103,
-0.21933050453662872,
-0.5107033252716064,
-0.426230788230896,
0.28647303581237793,
0.21459926664829254,
-0.6081386804580688,
0.08109062165021896,
0.7097064256668091,
0.6929236054420471,
0.03861171752214432,
0.5694695711135864,
0.5422550439834595,
0.23858046531677246,
0.016214849427342415,
0.9522808790206909,
-0.0433935783803463,
-0.662258505821228,
-1.0033082962036133,
-0.22519327700138092,
0.4582059681415558,
-0.5933306813240051,
-0.12611863017082214,
0.5356069207191467,
-0.2194565385580063,
-0.2908584475517273,
-0.07647290080785751,
-0.4060761630535126,
-0.43192675709724426,
0.2851412296295166,
-0.18982060253620148,
-0.010080121457576752,
0.29721787571907043,
0.21858695149421692,
-0.2367096245288849,
0.07796628773212433,
0.27471545338630676,
-0.10655299574136734,
0.5930553078651428,
0.3518420159816742,
-0.32645678520202637,
0.6019124984741211,
0.05561462789773941,
-0.2604632079601288,
-0.6261582970619202,
0.3778570592403412,
0.08761591464281082,
-0.3991352617740631,
0.0712762326002121,
0.3410077393054962,
-0.11497968435287476,
-0.08254258334636688,
0.09744449704885483,
0.024621261283755302,
-0.7362024784088135,
-0.02495916374027729,
-0.3265339136123657,
-0.10527222603559494,
0.3825675845146179,
-0.09402857720851898,
0.4837195873260498,
-0.04717962443828583,
0.767045259475708,
-0.23850861191749573,
-0.007347751874476671,
-0.24993403255939484,
-0.043985337018966675,
-0.1320192664861679,
0.048054974526166916,
-0.22429300844669342,
0.10819947719573975,
0.42576315999031067,
-0.03586006537079811,
0.7583311200141907,
-0.26637813448905945,
0.12025953084230423,
0.15510137379169464,
-0.7303009629249573,
0.26402533054351807,
-0.1652793288230896,
-0.06879977136850357,
-0.38315969705581665,
0.30782797932624817,
-0.11088670045137405,
0.13657648861408234,
-0.47923797369003296,
-0.08082669228315353,
0.009724144823849201,
-0.2977777421474457,
0.06672083586454391,
0.20797580480575562,
0.11493857949972153,
0.04670870676636696,
0.03887586295604706,
0.4165433645248413,
0.256873220205307,
-0.5771770477294922,
0.061014533042907715,
0.6749829053878784,
0.5968669652938843,
0.20411565899848938,
-0.09126012027263641,
0.060132045298814774,
-0.5305652022361755,
-0.14056554436683655,
-0.20987805724143982,
0.4998509883880615,
0.6531199216842651,
-0.14418573677539825,
-0.11933600902557373,
-0.4611297845840454,
0.02021663449704647,
-0.06360071152448654,
0.058099694550037384,
-0.7450211048126221,
-0.05453817918896675,
0.2994564473628998,
-0.7676185369491577,
0.5976514220237732,
0.13132672011852264,
0.05066322907805443,
-0.4454432427883148,
-0.3164812922477722,
0.39201098680496216,
-0.33619749546051025,
-0.6297143697738647,
-0.43454450368881226,
0.26598748564720154,
0.6188318729400635,
-0.2084382325410843,
0.08251636475324631,
0.07749398797750473,
0.057769786566495895,
-0.06951441615819931,
0.3174649775028229,
-0.17131732404232025,
-0.19332991540431976,
-0.16962814331054688,
-0.08805104345083237,
-0.2990979552268982,
0.7093905806541443,
0.36465445160865784,
-1.0818984508514404,
0.05170382186770439,
-0.23038314282894135,
0.020258983597159386,
-0.7325144410133362,
0.2154342383146286,
0.02481692284345627,
-0.34275951981544495,
-0.5078637599945068,
-0.3410443663597107,
0.06744362413883209,
0.1595272421836853,
0.7259761095046997,
-0.13526125252246857,
0.26554691791534424,
-0.8091616034507751,
-0.26266220211982727,
-0.347980260848999,
0.0033678377512842417,
0.4582718014717102,
-0.5582161545753479,
-0.7428205609321594,
-0.3176499009132385,
0.140595942735672,
-0.4241683781147003,
-0.08682890981435776,
0.05611865967512131,
1.2088006734848022,
0.31764429807662964,
-0.12229069322347641,
-0.6408423185348511,
-0.06200506538152695,
0.009542079642415047,
0.033300720155239105,
0.03190192952752113,
-0.49075981974601746,
-0.06778185814619064,
0.24120992422103882,
-0.10773088783025742,
-0.19191883504390717,
-0.6374357342720032,
0.32705485820770264,
0.009005074389278889,
-0.15453843772411346,
0.5609216094017029,
0.4930057227611542,
0.6547989845275879,
-0.3074333071708679,
0.4297039806842804,
-0.12625466287136078,
-0.00795537605881691,
-0.18947391211986542,
0.6098555326461792,
-0.5412508845329285,
-0.535179615020752,
0.4097863435745239,
-0.369953989982605,
0.37695538997650146,
-0.363667368888855,
0.21062330901622772,
-0.08986499160528183,
0.21624459326267242,
-0.2533070147037506,
-0.2106548696756363,
-0.17539578676223755,
-0.9890379905700684,
-0.37850674986839294,
0.19167548418045044,
0.13400235772132874,
0.3519161641597748,
-0.1730789989233017,
-0.04055698588490486,
-0.13884660601615906,
-0.48861923813819885,
0.7683325409889221,
0.4880094528198242,
-0.9286797046661377,
0.5323407649993896,
0.21940737962722778,
0.33483681082725525,
0.48125380277633667,
-0.22189055383205414,
0.010022195987403393,
0.021489214152097702,
-0.19529394805431366,
0.5399256944656372,
0.16353833675384521,
-0.4856832027435303,
0.1615888625383377,
-0.1529143899679184,
-0.11810439079999924,
0.45504137873649597,
-0.18686045706272125,
0.0462455078959465,
0.3652331531047821,
0.12633270025253296,
-0.13980677723884583,
-0.5447115302085876,
0.7790429592132568,
0.20869511365890503,
-0.4371737837791443,
-0.46151068806648254,
0.39193210005760193,
0.6881443858146667,
0.23888374865055084,
-0.2563699185848236,
0.05855493247509003,
-0.1883118450641632,
0.1993476301431656,
0.11906766891479492,
-0.005965372547507286,
-0.40237143635749817,
0.5647649168968201,
0.019201111048460007,
0.09846899658441544,
-0.6255941390991211,
0.19444869458675385,
-0.2626620829105377,
0.4279271364212036,
-0.01289473194628954,
0.19471429288387299,
-0.07866355776786804,
0.18869437277317047,
0.28115302324295044,
-0.1705666482448578,
0.0467391312122345,
0.38719287514686584,
-0.21847419440746307,
-0.438234806060791,
0.689960241317749,
-0.7116168141365051,
-0.033639851957559586,
0.30057623982429504,
0.1694924384355545,
0.8065010905265808,
-0.2315768599510193,
0.676969051361084,
-0.4566839337348938,
-0.06258728355169296,
0.41097503900527954,
-0.27352988719940186,
-0.17054858803749084,
-0.5349048376083374,
0.30750572681427,
0.12639585137367249,
-0.1963270753622055,
0.5078310370445251,
-0.26306456327438354,
0.002121252240613103,
0.004032759461551905,
-0.07298880815505981,
0.14076484739780426,
0.17317740619182587,
0.06532049924135208,
-0.39077866077423096,
0.21484895050525665,
-0.4738723337650299,
0.29268592596054077,
-0.26557406783103943,
-0.11378243565559387,
0.22640663385391235,
0.26019948720932007,
-0.19005687534809113,
0.17573003470897675,
-1.3263874053955078,
0.24571514129638672,
0.15210705995559692,
-0.20232145488262177,
-0.21704339981079102,
-0.43013349175453186,
0.8653302192687988,
0.39803871512413025,
0.4436589777469635,
-0.10473860055208206,
-0.04005340486764908,
-0.26605066657066345,
0.7525017261505127,
-0.48079296946525574,
0.594158947467804,
-0.36408764123916626,
-0.07104551792144775,
-0.8112504482269287,
0.4022124707698822,
0.8555253744125366,
0.4713151156902313,
-0.02204119600355625,
-0.30619585514068604,
-0.1501501351594925,
0.3386801481246948,
0.23663103580474854,
-0.6100552082061768,
0.08012434840202332,
-0.36561083793640137,
0.1612245738506317,
-0.6147613525390625,
0.6763710975646973,
0.06575880944728851,
-0.014529065228998661,
-0.22396685183048248,
0.2764681577682495,
0.7106970548629761,
-0.4660545587539673,
0.3500199019908905,
0.21143695712089539,
-0.20815381407737732,
-0.36657536029815674,
0.608665943145752,
-0.5810571908950806,
0.368392676115036,
0.12165001779794693,
0.4688592255115509,
0.1962900161743164,
-0.34101447463035583,
0.11308355629444122,
0.16603770852088928,
0.1423136293888092,
0.13213397562503815,
-0.04013752564787865,
0.5028071403503418,
0.18952253460884094,
-0.30221766233444214,
-1.107961654663086,
0.3369682729244232,
-0.17823198437690735,
-0.08554252982139587,
-0.040525808930397034,
-0.32197269797325134,
-0.2535768747329712,
0.11576307564973831,
0.12939302623271942,
-0.21219435334205627,
-0.11977085471153259,
0.02741672284901142
] |
Primary influenza pneumonia has a high mortality rate during pandemics, not only in immunocompromised individuals and patients with underlying comorbid conditions, but also in young healthy adults. Clinicians should maintain a high index of suspicion for this diagnosis in patients presenting with influenza-like symptoms that progress quickly (2 to 5 days) to respiratory distress and extensive pulmonary involvement. The sensitivity of rapid diagnostic techniques in identifying infections with the pandemic 2009 H1N1v influenza strain is currently suboptimal. The most reliable real-time reverse transcriptase-polymerase chain reaction molecular testing is available in limited clinical settings. Despite 6 months of pandemic circulation, most novel H1N1v pandemic strains remain susceptible to oseltamivir. Ensuring an appropriate oxygenation and ventilation strategy, as well as prompt initiation of antiviral therapy, is essential in management. | [
-0.007005952764302492,
0.01936478167772293,
-0.019723502919077873,
0.01718524470925331,
-0.0040024202316999435,
-0.005632256623357534,
0.009504184126853943,
0.012858221307396889,
-0.012593843042850494,
-0.03180655092000961,
-0.004007733892649412,
0.01087898388504982,
0.018971623852849007,
0.004928317852318287,
0.003528296947479248,
-0.0017443648539483547,
-0.0001738418359309435,
0.04107334464788437,
0.012135196477174759,
-0.004855077248066664,
-0.004753985442221165,
-0.008060075342655182,
0.01129724457859993,
0.032014213502407074,
0.018920529633760452,
-0.005081960931420326,
0.005788865033537149,
0.0015554429264739156,
-0.010475285351276398,
0.0032771704718470573,
0.00967937521636486,
0.004851710982620716,
0.010735485702753067,
-0.005327464547008276,
0.009212471544742584,
-0.014446062967181206,
0.00019124592654407024,
0.008868981152772903,
0.006734938360750675,
-0.002814974170178175,
0.0010994551703333855,
-0.010567295365035534,
-0.0007111418526619673,
-0.010166170075535774,
-0.004526718985289335,
0.019888918846845627,
-0.006852344609797001,
0.012058604508638382,
-0.01873869076371193,
0.007644833996891975,
-0.0041502988897264,
0.024877261370420456,
-0.014208924025297165,
0.00035425880923867226,
-0.006744269281625748,
0.007507719099521637,
0.02050478756427765,
0.035460468381643295,
-0.03132934123277664,
0.015435367822647095,
0.01648370921611786,
-0.004445235710591078,
0.0029744517523795366,
-0.0003160969354212284,
-0.0030474949162453413,
-0.06666802614927292,
0.0018894774839282036,
0.013848526403307915,
-0.0016498725162819028,
0.007292256690561771,
0.013651964254677296,
0.005042192526161671,
-0.004030104260891676,
0.006719067692756653,
0.0039902497082948685,
0.005015242379158735,
-0.002382897771894932,
0.019464582204818726,
0.004035486374050379,
0.005208368878811598,
0.011982070282101631,
0.006088580936193466,
0.01942571997642517,
0.012053746730089188,
-0.013204196467995644,
0.024468496441841125,
-0.01608027145266533,
0.00938565842807293,
-0.009442051872611046,
-0.008598675020039082,
0.012039151974022388,
-0.004098052624613047,
-0.02547280304133892,
-0.01527444738894701,
0.01640819013118744,
0.001130719669163227,
-0.007199151907116175,
0.0387130007147789,
0.016087224707007408,
-0.02079029381275177,
-0.006679344456642866,
0.023058248683810234,
0.02030894160270691,
0.009447517804801464,
-0.03250270336866379,
0.005827592685818672,
-0.006235239561647177,
0.006002646405249834,
0.02203327603638172,
0.0002614818513393402,
0.002387327142059803,
-0.006378096528351307,
0.011626770719885826,
0.002892934251576662,
-0.0044588614255189896,
0.006153382360935211,
0.013678206130862236,
0.012339049950242043,
-0.0003733734483830631,
-0.03683505207300186,
0.030173229053616524,
-0.01058216206729412,
-0.002955380594357848,
0.01269716490060091,
-0.0018411136697977781,
0.004330560564994812,
-0.01043751835823059,
-0.02340724878013134,
0.007351284846663475,
-0.0038702823221683502,
-0.00685329083353281,
-0.006371081341058016,
-0.016956139355897903,
-0.00503943907096982,
-0.004771255888044834,
0.0009518828010186553,
-0.007370784413069487,
-0.0026723905466496944,
-0.00008846307173371315,
-0.01428768690675497,
-0.013470365665853024,
0.008357935585081577,
-0.0018343093106523156,
0.014836274087429047,
-0.010002011433243752,
0.01754019595682621,
-0.008484632708132267,
0.012274911627173424,
0.03716342896223068,
-0.02277553267776966,
-0.0015339564997702837,
0.011034080758690834,
-0.012226952239871025,
-0.007676651701331139,
0.013980106450617313,
-0.0047271959483623505,
-0.005590587854385376,
-0.019689053297042847,
-0.00884824339300394,
0.00626728031784296,
0.021771974861621857,
0.01911882683634758,
-0.015489667654037476,
0.010313354432582855,
0.011902553029358387,
-0.014516569674015045,
0.026116596534848213,
-0.009592106565833092,
-0.01221616379916668,
0.0036368723958730698,
-0.00642943661659956,
-0.00031757913529872894,
-0.019468674436211586,
0.015215198509395123,
0.03405722230672836,
-0.007756840903311968,
0.01201772689819336,
0.006709353998303413,
-0.004348054062575102,
0.06603460013866425,
-0.020930126309394836,
0.0008590389043092728,
-0.010418323799967766,
0.03417380899190903,
0.030459191650152206,
-0.008608123287558556,
0.03233383595943451,
0.006126447580754757,
-0.001238939817994833,
-0.022973529994487762,
0.016029736027121544,
-0.017353886738419533,
-0.013322310522198677,
-0.007668802049010992,
-0.003886403050273657,
0.0037783433217555285,
-0.018534556031227112,
0.0040678419172763824,
-0.019387567415833473,
0.02547243982553482,
0.0001675635576248169,
0.01317478809505701,
0.0248117633163929,
0.003892510663717985,
-0.02728140912950039,
0.00890987366437912,
-0.011174613609910011,
0.003270738525316119,
0.007712332531809807,
-0.01233932375907898,
0.024289485067129135,
-0.013368804939091206,
-0.00472675496712327,
-0.0060434164479374886,
-0.016155332326889038,
-0.010985961183905602,
0.0038629972841590643,
0.006892728619277477,
-0.013954851776361465,
-0.018079668283462524,
0.016209889203310013,
0.028631478548049927,
-0.02744210883975029,
0.011553574353456497,
-0.0014229095540940762,
-0.019991479814052582,
-0.011841416358947754,
0.009143072180449963,
-0.00006198161281645298,
0.023408906534314156,
-0.020283017307519913,
-0.01455862820148468,
-0.008397962898015976,
-0.022800548002123833,
0.012744401581585407,
-0.011731782928109169,
0.01362575963139534,
-0.019957613199949265,
0.01167468074709177,
-0.01893901452422142,
-0.033796362578868866,
-0.0003887861967086792,
0.027385547757148743,
-0.024476774036884308,
0.02251567877829075,
-0.005374446045607328,
0.016077261418104172,
0.008470808155834675,
-0.02451450563967228,
0.004799125716090202,
0.010289706289768219,
-0.010712208226323128,
0.012913319282233715,
0.030474621802568436,
0.01456846110522747,
-0.00934574194252491,
0.008471066132187843,
0.0022439351305365562,
0.027214698493480682,
0.014236493036150932,
0.015745501965284348,
0.0060615213587880135,
-0.0040841600857675076,
-0.023076361045241356,
0.014024092815816402,
0.021094802767038345,
-0.019464202225208282,
0.015468578785657883,
0.0026630409993231297,
-0.01679852046072483,
0.004427048843353987,
-0.013066301122307777,
-0.00854506902396679,
-0.08135195076465607,
-0.011377811431884766,
-0.002198397181928158,
-0.007857944816350937,
0.009754955768585205,
0.0023040794767439365,
-0.002881546039134264,
0.014694834128022194,
-0.007715676911175251,
0.03063281998038292,
-0.016071949154138565,
0.0006393617950379848,
0.005173665937036276,
0.013968723826110363,
0.012117424048483372,
0.00036726566031575203,
0.006069631315767765,
0.006351260468363762,
-0.024873457849025726,
-0.011818483471870422,
-0.01970185711979866,
0.0013227923773229122,
0.018332939594984055,
-0.011878258548676968,
-0.019808443263173103,
-0.00990699790418148,
-0.0009674846660345793,
0.011011919006705284,
0.002741787116974592,
0.007592502981424332,
0.0024064022582024336,
-0.029423704370856285,
-0.009071031585335732,
-0.01718299463391304,
0.008812322281301022,
0.0029340144246816635,
-0.009549163281917572,
-0.0034331688657402992,
-0.0053161997348070145,
0.011310740374028683,
-0.015056857839226723,
0.0066507491283118725,
-0.004766250494867563,
-0.003289890242740512,
-0.005884573794901371,
-0.0012378445826470852,
0.009706387296319008,
0.029650725424289703,
0.02071775496006012,
0.0021125352941453457,
-0.008414095267653465,
-0.010415186174213886,
-0.005153270438313484,
0.010533161461353302,
-0.0021521439775824547,
-0.02375565469264984,
0.009189562872052193,
0.013238564133644104,
-0.013117056339979172,
-0.007735865656286478,
-0.013512695208191872,
0.008143598213791847,
0.007794723846018314,
-0.005605075974017382,
-0.008436590433120728,
-0.013438068330287933,
0.014652503654360771,
-0.03937913104891777,
-0.018721316009759903,
-0.0003404957242310047,
0.004357350990176201,
0.015411103144288063,
0.008104627020657063,
-0.013736044988036156,
0.019816257059574127,
-0.0012676509795710444,
-0.012457260861992836,
-0.013412678614258766,
0.0066558001562952995,
-0.015826456248760223,
-0.0008544810116291046,
-0.007122843526303768,
0.008012419566512108,
0.024577463045716286,
-0.023761898279190063,
0.012686577625572681,
0.013166486285626888,
-0.0009673126041889191,
0.01863991841673851,
-0.019889257848262787,
0.007416100241243839,
0.0074319420382380486,
-0.018077140673995018,
0.009271252900362015,
-0.028418898582458496,
-0.03344440460205078,
-0.01979692652821541,
-0.02190401218831539,
0.017380893230438232,
0.008782622404396534,
-0.014510249719023705,
-0.0169140063226223,
0.0023602312430739403,
-0.005882977042347193,
-0.028574060648679733,
0.014136552810668945,
-0.009998580440878868,
-0.01726479083299637,
-0.021776078268885612,
-0.0062429653480648994,
0.0066221472807228565,
0.012794340960681438,
-0.002982356585562229,
0.0025220131501555443,
0.005734360311180353,
0.04697708785533905,
0.013409800827503204,
-0.002863449277356267,
0.07160195708274841,
0.002050657756626606,
0.00874644797295332,
-0.010930584743618965,
-0.005601147189736366,
-0.01658761128783226,
0.012187918648123741,
0.0007670323830097914,
0.029520340263843536,
-0.009750636294484138,
0.014493776485323906,
-0.0036030206829309464,
0.008515827357769012,
-0.019773056730628014,
0.019794080406427383,
-0.022572718560695648,
-0.019044848158955574,
-0.011817147955298424,
0.019197572022676468,
0.01264254655689001,
0.0001530214212834835,
-0.004325177986174822,
-0.012948242016136646,
-0.0071722716093063354,
0.0020554247312247753,
0.03016998991370201,
0.04075649380683899,
-0.01608370617032051,
0.0019563259556889534,
0.007524670567363501,
0.011525790207087994,
0.021731294691562653,
-0.004306131973862648,
0.0066962954588234425,
-0.013066527433693409,
-0.008394859731197357,
-0.019510455429553986,
0.005314402747899294,
0.010325206443667412,
-0.023387040942907333,
-0.012593096122145653,
-0.014367806725203991,
-0.011515645310282707,
0.0008813841268420219,
-0.012008678168058395,
0.01973675936460495,
0.004896143451333046,
-0.007120391353964806,
-0.016366979107260704,
-0.010529203340411186,
-0.01284012757241726,
-0.014044777490198612,
0.010891526006162167,
0.011905308812856674,
-0.017603876069188118,
0.002859956119209528,
0.020885519683361053,
-0.01680973917245865,
0.0035328222438693047,
-0.027435757219791412,
0.016432031989097595,
-0.021037956699728966,
-0.020327342674136162,
-0.0027395011857151985,
-0.006952746771275997,
0.002505491953343153,
-0.01646300032734871,
0.004587296862155199,
-0.022978560999035835,
0.00914420373737812,
-0.0008043688721954823,
-0.02594933658838272,
0.0013084921520203352,
-0.002758667804300785,
-0.0200613085180521,
0.016549870371818542,
-0.020492050796747208,
0.014994018711149693,
-0.005192396230995655,
-0.013546595349907875,
-0.025978010147809982,
0.05804500728845596,
0.030075643211603165,
-0.023649143055081367,
0.0074385059997439384,
-0.00963510386645794,
-0.023188021034002304,
-0.07471964508295059,
-0.031105883419513702,
0.0019601883832365274,
-0.010906239040195942,
-0.005645337048918009,
0.006401051767170429,
-0.020029950886964798,
-0.0011071956250816584,
-0.025756798684597015,
-0.004460511729121208,
-0.014978911727666855,
0.016002118587493896,
0.028233885765075684,
-0.006457122974097729,
0.012966880574822426,
0.0036119017750024796,
-0.014296440407633781,
0.003116116626188159,
-0.026749834418296814,
0.007229858078062534,
-0.008366234600543976,
0.03800508379936218,
-0.034365374594926834,
-0.003789499867707491,
0.002201518276706338,
-0.08077477663755417,
-0.016836756840348244,
0.008866464719176292,
-0.011309516616165638,
-0.013883702456951141,
0.0025574108585715294,
0.02232282981276512,
-0.026634806767106056,
-0.005447886884212494,
-0.015147379599511623,
0.006907629314810038,
0.009743202477693558,
0.007780841551721096,
-0.017927218228578568,
0.02877741865813732,
-0.00919635221362114,
0.02042296901345253,
-0.00643432792276144,
0.0188924390822649,
-0.028075003996491432,
-0.009590442292392254,
0.028613846749067307,
-0.008211767300963402,
-0.006219471804797649,
-0.010951785370707512,
-0.017973698675632477,
-0.011764813214540482,
0.01111245434731245,
-0.004179523792117834,
-0.044604554772377014,
-0.006760853808373213,
-0.035447437316179276,
-0.016749698668718338,
0.023303356021642685,
0.025663387030363083,
-0.01513157319277525,
0.015572289936244488,
0.005190534982830286,
0.008782872930169106,
-0.009756403043866158,
-0.001219891244545579,
0.038088712841272354,
-0.005404970608651638,
-0.0037326114252209663,
0.0063293310813605785,
-0.014521423727273941,
0.004466311540454626,
-0.015081547200679779,
0.019315604120492935,
-0.013893257826566696,
0.007614073809236288,
-0.0048698484897613525,
0.01826046034693718,
0.009954474866390228,
-0.0010192161425948143,
-0.0005256937583908439,
-0.0093228192999959,
-0.008033601567149162,
0.007510927505791187,
0.01770060323178768,
-0.007668427191674709,
0.007027413230389357,
-0.02844337560236454,
0.07082875818014145,
-0.008920911699533463,
0.012846942991018295,
-0.014317870140075684,
-0.01071874424815178,
0.0034616405609995127,
-0.001588327344506979,
0.018479324877262115,
-0.016277892515063286,
-0.017145298421382904,
0.006362313870340586,
-0.008712885901331902,
0.0027865413576364517,
0.004734988324344158,
0.0030271767172962427,
0.012040155939757824,
0.014968546107411385,
-0.015350054018199444,
-0.026439715176820755,
-0.030336745083332062,
-0.01595809869468212,
0.01532178744673729,
-0.023683052510023117,
0.005439768545329571,
0.026193084195256233,
-0.001839280710555613,
-0.0068847620859742165,
-0.016676273196935654,
-0.016256725415587425,
-0.007935911417007446,
-0.0319131538271904,
-0.007240580394864082,
0.005314032547175884,
0.001903953030705452,
0.010263068601489067,
-0.021471135318279266,
0.010715799406170845,
0.01273223664611578,
0.013638374395668507,
0.002715872833505273,
0.018968980759382248,
-0.010535594075918198,
0.010437579825520515,
-0.0033538914285600185,
0.03426550701260567,
-0.025542356073856354,
0.0401555597782135,
0.03284476697444916,
0.012008510529994965,
0.015488850884139538,
-0.010652964934706688,
0.007864430546760559,
0.011613471433520317,
-0.010878032073378563,
-0.01762419380247593,
-0.0032855463214218616,
-0.02140863798558712,
0.016978666186332703,
-0.0063370815478265285,
0.010892271995544434,
0.009285494685173035,
-0.006359885446727276,
-0.0038405517116189003,
-0.014397559687495232,
0.017568891867995262,
0.014195267111063004,
-0.0028791341464966536,
-0.014739412814378738,
-0.0077789705246686935,
0.00933886133134365,
0.0018382503185421228,
0.017616301774978638,
0.006275806576013565,
-0.015362315811216831,
0.0166388601064682,
0.021561486646533012,
0.04272221773862839,
0.003951305523514748,
0.010698544792830944,
0.0045954086817801,
-0.02082490548491478,
-0.015330946072936058,
0.005247361026704311,
-0.000785288168117404,
-0.019643399864435196,
-0.004834481980651617,
0.02144065871834755,
-0.019344720989465714,
-0.008085441775619984,
0.004090862348675728,
0.019558316096663475,
0.02100973203778267,
0.004185503348708153,
-0.01061219722032547,
0.004603583365678787,
0.03581516444683075,
-0.006351852789521217,
0.011329114437103271,
0.017136527225375175,
-0.004294590558856726,
-0.005654023960232735,
-0.015271350741386414,
0.0021836301311850548,
0.0036729471758008003,
0.02392422780394554,
-0.008130041882395744,
-0.010817507281899452,
-0.0006438316777348518,
-0.0013822545297443867,
0.024475570768117905,
-0.0078091127797961235,
-0.0012910418445244431,
0.06508190929889679,
-0.02591606229543686,
0.012288982048630714,
-0.004726097919046879,
0.0016557190101593733,
-0.008321035653352737,
0.005302425008267164,
-0.011612103320658207,
-0.0035717138089239597,
0.003437429666519165,
-0.009819680824875832,
0.033364154398441315,
0.0016161487437784672,
-0.01784280687570572,
-0.0034542956855148077,
-0.02446453645825386,
0.005704492796212435,
-0.01564517244696617,
0.012517781928181648,
-0.01132461428642273,
-0.01222628727555275,
0.0033431476913392544,
-0.024766433984041214,
0.005954371765255928,
-0.0028075913432985544,
0.019979871809482574,
-0.027783246710896492,
0.005303163081407547,
-0.022864017635583878,
-0.011061646044254303,
0.005396593362092972,
-0.013648099265992641,
0.009690367616713047,
0.006611961405724287,
-0.030058663338422775,
0.014181992970407009,
0.016997026279568672,
0.008422682993113995,
-0.011327756568789482,
0.010044561699032784,
0.00025661580730229616,
-0.008309283293783665,
0.01757613569498062,
-0.010622244328260422,
0.015443161129951477,
-0.026395240798592567,
-0.003205462358891964,
0.006722662597894669,
0.0006474039983004332,
-0.003988360986113548,
0.0164951141923666,
-0.0013190687168389559,
-0.027404475957155228,
0.012637278065085411,
0.01870185136795044,
0.026899419724941254,
-0.011108667589724064,
-0.0060639046132564545,
-0.026936419308185577,
-0.020084982737898827,
0.0148009043186903,
0.015079472213983536,
-0.006547280587255955,
-0.017497383058071136,
-0.0035075244959443808,
0.012497993186116219,
-0.01280058640986681,
0.020151691511273384,
0.0006967239314690232,
-0.012501725926995277,
-0.0032570213079452515,
-0.01138596422970295,
0.0039299908094108105,
-0.000871710479259491,
-0.014626186341047287,
0.02061358094215393,
0.027273081243038177,
0.02552083134651184,
-0.023652315139770508,
-0.026914656162261963,
-0.012091014534235,
0.040049221366643906,
-0.0013319326099008322,
0.01548786461353302,
-0.01197822391986847,
-0.037126775830984116,
0.015996156260371208,
0.015750931575894356,
-0.0032752524130046368,
-0.01591239869594574
] | [
0.15777015686035156,
-0.23176652193069458,
-0.10846519470214844,
-0.13250921666622162,
-0.03729085251688957,
-0.38826984167099,
0.41169309616088867,
-0.051941897720098495,
-0.4868696331977844,
-0.40175938606262207,
-0.025761621072888374,
0.01964293047785759,
-0.7409277558326721,
0.41791847348213196,
0.1886545717716217,
0.3351077735424042,
0.2159726619720459,
0.45174264907836914,
-0.07603252679109573,
-0.4158799946308136,
-0.9498292207717896,
-0.2503868639469147,
0.05874389037489891,
0.31025269627571106,
-0.06983157992362976,
-0.23934902250766754,
0.26023924350738525,
-0.24592407047748566,
0.2421373575925827,
-0.40326353907585144,
0.08302928507328033,
0.39049139618873596,
0.35975590348243713,
-0.32157251238822937,
-0.027885939925909042,
-0.09988059848546982,
-0.10767079889774323,
-0.13740000128746033,
-0.22137728333473206,
-0.329702764749527,
-0.45244070887565613,
0.031509801745414734,
-0.32906508445739746,
0.3908270001411438,
0.35747969150543213,
-0.5884984135627747,
-0.7520683407783508,
0.5267362594604492,
0.1815769076347351,
0.003130898578092456,
0.10179068148136139,
-0.1120646744966507,
0.35299521684646606,
0.1523406207561493,
-0.21423234045505524,
0.35841599106788635,
-0.736708402633667,
0.2254563570022583,
-0.08172439783811569,
-0.013518262654542923,
0.05270640552043915,
-0.5502659678459167,
-0.1919538974761963,
0.667051374912262,
0.3325364589691162,
0.2593691945075989,
0.09422428905963898,
0.44971492886543274,
-0.058046624064445496,
0.01407553069293499,
-0.28096532821655273,
-0.30670008063316345,
-0.3557887673377991,
-0.1469489485025406,
0.08325286209583282,
0.281263142824173,
-0.06965303421020508,
-0.4781111478805542,
0.2852714955806732,
0.3986714780330658,
-0.24331802129745483,
-0.07599957287311554,
-0.19185249507427216,
-0.31157904863357544,
0.5687248110771179,
0.4045792520046234,
0.19120657444000244,
1.0431456565856934,
0.09692319482564926,
0.4408029019832611,
0.460819274187088,
-0.07507678121328354,
0.34890884160995483,
-0.13288244605064392,
-0.22759617865085602,
0.29155802726745605,
0.08984705060720444,
0.37247422337532043,
0.24974992871284485,
-0.5208385586738586,
-0.7613383531570435,
0.04754354804754257,
-0.0033067455515265465,
-0.09331967681646347,
-0.11626710742712021,
-0.21913547813892365,
-0.3546156585216522,
-0.44867464900016785,
-0.37874898314476013,
-0.01568947546184063,
-0.13370026648044586,
-0.19850292801856995,
-0.4602039158344269,
-0.3217106759548187,
-0.5575446486473083,
0.3320077061653137,
0.08181831240653992,
-0.6034736633300781,
-0.25764596462249756,
-0.18739250302314758,
-0.1321508288383484,
0.6957574486732483,
-0.3432474136352539,
0.36787381768226624,
-0.1714702993631363,
0.15993404388427734,
0.6107648611068726,
-0.0408681258559227,
0.27135828137397766,
0.16394026577472687,
0.22798947989940643,
0.6095792651176453,
-0.3027682900428772,
-0.026009388267993927,
0.17841021716594696,
-0.020295385271310806,
-0.3835241496562958,
0.3884578049182892,
0.6248747110366821,
-0.487777441740036,
-0.6801559329032898,
-0.8802089691162109,
-0.018093334510922432,
-0.018499357625842094,
-0.3544856309890747,
0.4419631063938141,
-0.4916989207267761,
-0.021359102800488472,
-0.1886029839515686,
-0.327369749546051,
0.2490808516740799,
0.15887895226478577,
-0.408691942691803,
-0.100710429251194,
-0.38711726665496826,
0.11109588295221329,
0.3391371965408325,
-0.39575326442718506,
-0.22757120430469513,
0.038790490478277206,
0.7482271790504456,
0.05468801036477089,
-0.1679830402135849,
0.29730626940727234,
0.5816051959991455,
-0.06449717283248901,
-0.06938671320676804,
0.34668242931365967,
0.06987769156694412,
-0.476041704416275,
-0.30651724338531494,
-0.18889516592025757,
0.0006497271242551506,
-1.0477800369262695,
-0.27008795738220215,
-0.027548085898160934,
0.1871606409549713,
-0.017284009605646133,
0.6353327035903931,
-0.3673402965068817,
-0.4911740720272064,
0.5761659145355225,
0.2874124348163605,
-0.3368428945541382,
0.3474462032318115,
0.2150079756975174,
-0.2032495141029358,
0.09095290303230286,
0.20197288691997528,
-0.3316248655319214,
-0.26394689083099365,
-0.5078606009483337,
0.46133124828338623,
-0.4472631812095642,
1.0982208251953125,
-0.06278237700462341,
0.18169784545898438,
1.6924126148223877,
0.5120786428451538,
-0.4201693832874298,
0.19619937241077423,
0.5466001033782959,
0.5382815003395081,
-0.33827775716781616,
-1.1452932357788086,
-0.1971549242734909,
-0.11922259628772736,
-0.11426330357789993,
-0.022589433938264847,
0.07010842859745026,
0.501758337020874,
-0.023348618298768997,
-0.280479371547699,
-0.5455915927886963,
0.19667334854602814,
0.11163046956062317,
-0.49756404757499695,
-0.010684645734727383,
0.13367003202438354,
-0.22701425850391388,
0.03365187719464302,
-1.1509016752243042,
0.11323221772909164,
0.9344751834869385,
0.02722942642867565,
0.8643134236335754,
0.4779351055622101,
-0.4158327281475067,
0.8839905261993408,
-0.41576138138771057,
0.4819236695766449,
-0.3350480794906616,
0.2571437656879425,
-0.5803310871124268,
-0.08648592978715897,
0.15459157526493073,
-0.47485432028770447,
-0.35335925221443176,
-0.0568094439804554,
0.23875115811824799,
0.6264608502388,
0.36048001050949097,
-0.6946603655815125,
0.44342973828315735,
0.1420193761587143,
-0.3717057704925537,
-0.5326282382011414,
0.0916644036769867,
-0.7550534009933472,
0.14508046209812164,
0.3236508369445801,
0.449954092502594,
0.24980288743972778,
-0.4660109877586365,
0.19969810545444489,
-0.2634013891220093,
-0.2307925820350647,
-0.2629627585411072,
0.18322063982486725,
-0.26743701100349426,
0.14390432834625244,
0.48937609791755676,
-0.011341436766088009,
0.6509326100349426,
0.17556923627853394,
-0.564768373966217,
-0.7915950417518616,
-0.5876311659812927,
0.4479387402534485,
0.4083747863769531,
0.7814254760742188,
0.09960397332906723,
-0.3387785851955414,
-0.25176146626472473,
-0.06863000988960266,
-0.6473371982574463,
0.4147554039955139,
0.840450644493103,
-0.5911425948143005,
0.07041478902101517,
-0.12931376695632935,
0.11302264034748077,
0.3856806755065918,
-0.5677490830421448,
-0.6465091109275818,
-0.1123897135257721,
-0.3242987394332886,
-0.07630529999732971,
-0.29634204506874084,
-0.12908869981765747,
-0.5412753820419312,
0.4717863202095032,
-0.25023388862609863,
0.3928135931491852,
0.018372146412730217,
-0.3010747730731964,
-0.16685046255588531,
0.6963360905647278,
0.775524914264679,
-0.3747333288192749,
-0.18376240134239197,
-0.041420161724090576,
-0.21373705565929413,
-0.12762245535850525,
-0.41454485058784485,
0.20218192040920258,
-0.08710445463657379,
-0.09002973884344101,
-5.711039066314697,
-0.2896193563938141,
-0.5339337587356567,
-0.40735384821891785,
-0.09316892176866531,
-0.0567183718085289,
1.1055676937103271,
-0.16637538373470306,
0.539879560470581,
0.5313791036605835,
0.8372108340263367,
0.6086422801017761,
0.5897743105888367,
-0.3780392110347748,
-0.5047925710678101,
0.019738024100661278,
0.4181074798107147,
0.07666889578104019,
0.3493703603744507,
0.24570006132125854,
-0.10601446032524109,
0.4681718647480011,
0.10575947165489197,
0.4713650941848755,
-0.08337246626615524,
0.2586524784564972,
-0.8197887539863586,
0.2930113971233368,
-0.3999720811843872,
0.30949532985687256,
0.4704163372516632,
-0.7883689403533936,
0.17600345611572266,
0.25925856828689575,
-0.23500853776931763,
-0.09763849526643753,
-0.2677808403968811,
-0.19701454043388367,
-0.41434741020202637,
0.09566570073366165,
-0.09445114433765411,
-0.35844168066978455,
-0.2804429531097412,
-0.2717544436454773,
-0.2778477966785431,
-0.0026808662805706263,
0.21549488604068756,
0.04933948442339897,
0.2576149106025696,
0.8607919812202454,
0.18636511266231537,
-0.2521611154079437,
0.21637436747550964,
0.48656582832336426,
0.7536324858665466,
0.08020133525133133,
0.058397140353918076,
0.026005273684859276,
-0.5885194540023804,
0.02592531219124794,
-0.13171245157718658,
0.043167516589164734,
0.0958271250128746,
-0.4073981046676636,
-0.008114675991237164,
0.07388604432344437,
-0.5349369645118713,
-0.49650827050209045,
0.36471930146217346,
0.025592129677534103,
-0.1878860592842102,
0.2525612413883209,
0.5503091812133789,
-0.49935439229011536,
0.07069361954927444,
-0.8921645283699036,
0.13797441124916077,
0.5343895554542542,
0.2705983519554138,
-0.8118953108787537,
-0.45954275131225586,
-0.37031954526901245,
-0.09706372767686844,
-0.2992212474346161,
0.7409345507621765,
-0.2359916865825653,
-0.03258277475833893,
-0.304180771112442,
0.24455037713050842,
0.13642998039722443,
0.5643143653869629,
-0.3048923909664154,
-0.05711390823125839,
0.3039889931678772,
0.09272881597280502,
1.037254810333252,
0.21492235362529755,
0.6433806419372559,
0.7485677003860474,
0.13009126484394073,
0.9694401621818542,
-0.2705482840538025,
-0.5807108879089355,
-0.8510934114456177,
-0.11380541324615479,
-0.010720529593527317,
-0.09077620506286621,
-0.316392719745636,
1.0023064613342285,
-0.844082772731781,
0.6018116474151611,
0.14136873185634613,
-0.2290905863046646,
-0.16243192553520203,
0.4772462546825409,
-0.36793458461761475,
0.1451365053653717,
0.6433021426200867,
0.4783255457878113,
-0.2503926157951355,
0.7777544260025024,
0.3779081106185913,
-0.6191269159317017,
0.6671046018600464,
0.4026244878768921,
0.06563807278871536,
0.16517741978168488,
0.6064799427986145,
-0.6553982496261597,
-0.2755637764930725,
0.3024499714374542,
0.05829611048102379,
-0.1640971451997757,
-0.3075639009475708,
0.24976855516433716,
-0.08166506141424179,
-0.30108320713043213,
-0.3320241868495941,
-0.07619932293891907,
0.12403631955385208,
-0.3667422831058502,
0.018043071031570435,
-0.3061978816986084,
0.3492381274700165,
0.14847831428050995,
-0.19368377327919006,
-0.38758307695388794,
-0.4087025821208954,
-0.37598204612731934,
-0.3769354224205017,
0.5677470564842224,
-0.03112850710749626,
0.2918601334095001,
0.1895398646593094,
-1.0724763870239258,
0.23495835065841675,
0.4825931191444397,
-0.02774897590279579,
-0.38578206300735474,
-0.6591078042984009,
0.41567981243133545,
-0.41741669178009033,
-1.2148313522338867,
-0.38092613220214844,
-0.012266413308680058,
0.006229335442185402,
0.14436301589012146,
-0.22722840309143066,
-0.015158097259700298,
0.1740029901266098,
-0.32341569662094116,
-0.5378687381744385,
-0.1968739926815033,
-0.09850674867630005,
0.46667104959487915,
0.23192653059959412,
-0.5127866268157959,
0.18646734952926636,
0.1354828178882599,
0.36191636323928833,
0.20168818533420563,
-0.174070343375206,
-0.40008142590522766,
0.33136796951293945,
-0.05173099413514137,
0.3465070426464081,
0.13752524554729462,
-0.21139569580554962,
-0.8278843760490417,
0.09446397423744202,
0.48988276720046997,
0.1301511526107788,
0.577121913433075,
-0.346107542514801,
-0.16747543215751648,
-0.37534299492836,
-0.3498016595840454,
0.36839914321899414,
0.4067445993423462,
0.15558090806007385,
-0.04806625470519066,
0.5299732089042664,
-0.3583264946937561,
0.3076181411743164,
0.3162391483783722,
-0.3819032311439514,
-0.2685924470424652,
-0.01735900342464447,
0.10203756392002106,
-0.27615347504615784,
0.019933205097913742,
-0.6088088154792786,
0.16376963257789612,
0.8052158951759338,
-0.04394657537341118,
-0.07707296311855316,
-0.09666015952825546,
-0.49698305130004883,
0.6490462422370911,
0.3112642467021942,
0.015981195494532585,
0.19579152762889862,
-0.29295220971107483,
-0.3314456641674042,
0.037990227341651917,
0.711090624332428,
0.5668341517448425,
-0.9712086915969849,
0.11569061130285263,
0.16423295438289642,
-0.09144507348537445,
-0.44962406158447266,
0.5433446764945984,
-0.04599574953317642,
-0.5761875510215759,
-0.4181769788265228,
0.31382521986961365,
0.08621209859848022,
0.7430874109268188,
0.46998968720436096,
0.37850964069366455,
0.8048070669174194,
-0.19386397302150726,
-0.4770318269729614,
-0.04363369196653366,
-0.013359710574150085,
0.6465132236480713,
-0.7807917594909668,
-0.3659455180168152,
0.356208860874176,
0.08176151663064957,
-0.19569775462150574,
-0.08183761686086655,
-0.20469382405281067,
0.41953223943710327,
-0.17099565267562866,
-0.19081516563892365,
-0.1373489648103714,
-0.31438422203063965,
-0.09704679995775223,
0.08384684473276138,
-0.0808042511343956,
-0.3994685709476471,
0.15333178639411926,
0.22367480397224426,
0.13008466362953186,
-0.40383630990982056,
-0.3517546057701111,
-0.2609347701072693,
-0.22361908853054047,
-0.06197784096002579,
-0.25583142042160034,
0.7148726582527161,
0.4839237332344055,
0.38687241077423096,
0.4516715109348297,
-0.396427184343338,
0.09922374039888382,
-0.2675482928752899,
0.518196165561676,
-0.01957293227314949,
-0.9221388101577759,
0.24774621427059174,
-0.1041654646396637,
0.1771000325679779,
-0.5799526572227478,
-0.04926811531186104,
-0.2341175228357315,
-0.2649443745613098,
-0.26514530181884766,
-0.38440659642219543,
0.20223060250282288,
-0.6112056970596313,
-0.4616639316082001,
-0.10536155849695206,
0.3767586052417755,
-0.004635701887309551,
0.8649327754974365,
-0.10340243577957153,
-0.33073174953460693,
-0.5195467472076416,
0.6710052490234375,
0.3368481993675232,
-0.40298759937286377,
0.32394522428512573,
0.07929516583681107,
0.027480266988277435,
0.08369157463312149,
-0.10257242619991302,
0.22272920608520508,
0.2845724821090698,
0.25256890058517456,
0.5383421778678894,
0.2836728096008301,
-0.37957870960235596,
0.3887706995010376,
-0.4861927628517151,
-0.13644947111606598,
0.4228314757347107,
-0.230751171708107,
0.684075653553009,
0.8442416191101074,
0.5364416241645813,
0.06276100873947144,
-0.6354488134384155,
0.44626420736312866,
-0.6637384295463562,
0.4375450015068054,
0.0833042562007904,
0.3615647554397583,
0.698352575302124,
0.16137990355491638,
-0.3741050660610199,
0.3704850375652313,
-0.05231431871652603,
0.4247892200946808,
0.22271691262722015,
-1.1466329097747803,
-0.4549209177494049,
-0.3417535126209259,
1.3563189506530762,
0.15660077333450317,
0.436362624168396,
0.18299473822116852,
-0.18704263865947723,
0.3565237522125244,
-0.0009657247574068606,
0.16211673617362976,
0.43110355734825134,
-0.3909374475479126,
0.6560215950012207,
-0.46454522013664246,
0.09368596225976944,
-0.1651005744934082,
-0.45903313159942627,
-0.03429821878671646,
0.43341949582099915,
-0.21520118415355682,
-0.4298883080482483,
-0.0946066603064537,
-0.33684054017066956,
-0.3624672591686249,
-0.06635140627622604,
0.4605659246444702,
0.22710219025611877,
-0.31121477484703064,
0.9504407644271851,
0.1397773176431656,
0.1700388640165329,
-0.4203135371208191,
-0.1422790139913559,
-0.5604196190834045,
-0.1754160225391388,
0.20951932668685913,
0.7109066843986511,
-0.183262437582016,
-0.2599102556705475,
0.4730927646160126,
0.14882051944732666,
0.2843625843524933,
-0.597888708114624,
-0.09211388230323792,
0.042499542236328125,
-0.12928186357021332,
-0.5618883371353149,
-0.2186817079782486,
-0.42778223752975464,
-0.1960243135690689,
0.07670170068740845,
0.006731926929205656,
0.17437610030174255,
0.11072295904159546,
0.39688342809677124,
0.4317302405834198,
0.0019432870903983712,
-0.2503560185432434,
0.4125472605228424,
0.2293374240398407,
-0.14472909271717072,
0.6347162127494812,
-0.42442238330841064,
0.3501633107662201,
-0.738671064376831,
0.5593038201332092,
-0.33506450057029724,
0.5087777972221375,
-0.0955071672797203,
0.47983574867248535,
-0.8234756588935852,
0.2750396728515625,
0.5976597666740417,
0.34142911434173584,
-0.20329801738262177,
0.1821286678314209,
-0.1312427818775177,
0.044487081468105316,
0.39297428727149963,
-0.46485403180122375,
-0.29857829213142395,
-0.3841553032398224,
-0.574833869934082,
-0.4400325119495392,
0.687484860420227,
-0.22536878287792206,
-0.2122846245765686,
-0.00530419172719121,
0.11000362038612366,
0.5725187659263611,
-0.3206734359264374,
0.2581010162830353,
-0.4296718239784241,
0.33317068219184875,
-0.7584376931190491,
-0.019394325092434883,
-0.30218642950057983,
-0.2087838053703308,
0.2049553394317627,
0.2520785629749298,
0.6688655614852905,
-0.03399251401424408,
0.3290015459060669,
-0.6614082455635071,
0.13148687779903412,
-0.09412720799446106,
0.21087975800037384,
-0.062356606125831604,
0.42880484461784363,
-0.25869306921958923,
-1.1947174072265625,
0.05220597982406616,
-0.16038495302200317,
-0.4561813175678253,
-0.32934656739234924,
0.5332351922988892,
-0.37079399824142456,
-0.30576759576797485,
0.17711859941482544,
0.014085130766034126,
-0.012320474721491337,
0.12703785300254822
] |
BACKGROUND: Clearly air travel, by transporting infectious individuals from one geographic location to another, significantly affects the rate of spread of influenza A (H1N1). However, the possibility of within-flight transmission of H1N1 has not been evaluated; although it is known that smallpox, measles, tuberculosis, SARS and seasonal influenza can be transmitted during commercial flights. Here we present the first quantitative risk assessment to assess the potential for within-flight transmission of H1N1. METHODS: We model airborne transmission of infectious viral particles of H1N1 within a Boeing 747 using methodology from the field of quantitative microbial risk assessment. RESULTS: The risk of catching H1N1 will essentially be confined to passengers travelling in the same cabin as the source case. Not surprisingly, we find that the longer the flight the greater the number of infections that can be expected. We calculate that H1N1, even during long flights, poses a low to moderate within-flight transmission risk if the source case travels First Class. Specifically, 0-1 infections could occur during a 5 hour flight, 1-3 during an 11 hour flight and 2-5 during a 17 hour flight. However, within-flight transmission could be significant, particularly during long flights, if the source case travels in Economy Class. Specifically, two to five infections could occur during a 5 hour flight, 5-10 during an 11 hour flight and 7-17 during a 17 hour flight. If the aircraft is only partially loaded, under certain conditions more infections could occur in First Class than in Economy Class. During a 17 hour flight, a greater number of infections would occur in First Class than in Economy if the First Class Cabin is fully occupied, but Economy class is less than 30% full. CONCLUSIONS: Our results provide insights into the potential utility of air travel restrictions on controlling influenza pandemics in the winter of 2009/2010. They show travel by one infectious individual, rather than causing a single outbreak of H1N1, could cause several simultaneous outbreaks. These results imply that, during a pandemic, quarantining passengers who travel in Economy on long-haul flights could potentially be an important control strategy. Notably, our results show that quarantining passengers who travel First Class would be unlikely to be an effective control strategy. | [
-0.014843237586319447,
0.01342295203357935,
-0.004749688785523176,
0.021272113546729088,
0.017393002286553383,
-0.013325571082532406,
0.01033258531242609,
0.021950332447886467,
-0.017051521688699722,
-0.019101891666650772,
0.003987896256148815,
0.023884497582912445,
-0.007114193867892027,
0.030661772936582565,
-0.0027165126521140337,
-0.03828295320272446,
0.0063391481526196,
0.053092777729034424,
0.010402729734778404,
-0.003108859993517399,
-0.025250185281038284,
0.014601966366171837,
0.011984526179730892,
0.023041922599077225,
0.004435339942574501,
0.0187673419713974,
-0.011456573382019997,
-0.02220199815928936,
-0.017946869134902954,
0.020085375756025314,
-0.009091200307011604,
0.01014520600438118,
0.01521318405866623,
0.011467047967016697,
0.004244017414748669,
-0.006579957902431488,
-0.004605386406183243,
0.02695905789732933,
0.0020527546294033527,
-0.004106839187443256,
0.019046615809202194,
-0.015002865344285965,
0.00589710334315896,
-0.012430096045136452,
-0.009494825266301632,
0.022850921377539635,
-0.0032057426869869232,
-0.007473139092326164,
-0.0019011995755136013,
0.0020286915823817253,
-0.008499479852616787,
-0.024247795343399048,
-0.01441211998462677,
0.038098085671663284,
-0.007959495298564434,
0.009201656095683575,
0.023634517565369606,
0.027355380356311798,
-0.014127403497695923,
0.024171186611056328,
-0.003621452720835805,
0.03371061384677887,
0.009220050647854805,
0.014424879103899002,
0.008291663601994514,
-0.0659937784075737,
0.03836113587021828,
0.0038403780199587345,
0.018417159095406532,
0.006860383786261082,
-0.021230198442935944,
0.011062994599342346,
0.0024475855752825737,
-0.028418637812137604,
-0.022399600595235825,
0.01042754016816616,
0.008135169744491577,
0.024982979521155357,
-0.022170810028910637,
0.012980939820408821,
0.042017336934804916,
0.01825757697224617,
-0.014433341100811958,
0.014006719924509525,
-0.007928951643407345,
0.004261686000972986,
-0.02469264343380928,
-0.007805893197655678,
-0.004946114961057901,
0.0037710973992943764,
0.007539346814155579,
-0.006282049231231213,
-0.043123431503772736,
-0.04919091984629631,
-0.0077875638380646706,
-0.036651238799095154,
0.01779511198401451,
-0.023911364376544952,
0.012764567509293556,
-0.013105708174407482,
0.005854468792676926,
0.01002421323210001,
0.01885712333023548,
0.003030364867299795,
0.00670971255749464,
0.012765008956193924,
-0.016857637092471123,
-0.007345038000494242,
-0.004629035014659166,
0.007369390223175287,
-0.0008281050249934196,
-0.018341928720474243,
0.008294887840747833,
0.04689377173781395,
-0.0077189127914607525,
0.01556265726685524,
0.02250445820391178,
0.029420141130685806,
0.004632207565009594,
-0.012745562940835953,
0.00004838034510612488,
-0.02545880526304245,
0.013244614005088806,
-0.015634000301361084,
-0.0029482042882591486,
0.0006660952931270003,
-0.028734030202031136,
-0.0007365252822637558,
-0.008730215951800346,
-0.0053799948655068874,
-0.008048548363149166,
0.012519046664237976,
-0.009903399273753166,
-0.03929353132843971,
-0.012935999780893326,
0.014271974563598633,
-0.012814421206712723,
0.032686807215213776,
-0.0073089380748569965,
0.009656568057835102,
-0.02245195209980011,
0.01419832929968834,
-0.003615971188992262,
0.014799525961279869,
0.022797653451561928,
0.0046334099024534225,
-0.011565284803509712,
0.019904447719454765,
0.03984440118074417,
0.022383086383342743,
0.030694792047142982,
-0.008393385447561741,
0.005167629104107618,
-0.02137300744652748,
-0.0036300402134656906,
0.029493428766727448,
-0.0004365178756415844,
-0.0022743134759366512,
-0.023094061762094498,
-0.00027101393789052963,
0.013303946703672409,
-0.004508521407842636,
-0.0038068974390625954,
0.011573636904358864,
0.01565375179052353,
-0.03383346647024155,
0.050232917070388794,
-0.01810256391763687,
0.017160162329673767,
0.008177201263606548,
-0.008640483021736145,
-0.006998321041464806,
-0.010332316160202026,
0.009318211115896702,
0.02346205711364746,
0.008836218155920506,
0.018154021352529526,
0.010133366100490093,
0.009727229364216328,
0.0656975507736206,
0.00709394970908761,
-0.008994712494313717,
-0.00048154639080166817,
-0.014995289035141468,
-0.01231943815946579,
-0.03299952298402786,
0.028127705678343773,
-0.010535931214690208,
-0.010018857195973396,
0.006191655993461609,
-0.027395179495215416,
-0.030307158827781677,
-0.0013412991538643837,
-0.019965970888733864,
-0.006018282845616341,
0.004112402908504009,
0.01371860597282648,
0.012920297682285309,
0.005157046020030975,
0.016404666006565094,
0.03172227740287781,
0.03684210032224655,
0.030317820608615875,
0.007905651815235615,
0.005775156896561384,
0.011438483372330666,
-0.0018689582357183099,
0.011866360902786255,
0.012946918606758118,
-0.004799479153007269,
0.005796331912279129,
0.0039003610145300627,
-0.002809892874211073,
-0.024951821193099022,
-0.019103918224573135,
-0.00742572033777833,
0.010339425876736641,
0.021753575652837753,
0.009047402068972588,
-0.013399757444858551,
0.0010039887856692076,
0.002572614699602127,
-0.029727129265666008,
0.026282742619514465,
0.020458495244383812,
-0.012953143566846848,
-0.00020412402227520943,
0.016370203346014023,
0.0031582596711814404,
0.007327514700591564,
0.0018900602590292692,
-0.013610145077109337,
-0.01350460760295391,
0.02149099111557007,
0.019131194800138474,
-0.019364122301340103,
0.013122913427650928,
-0.005118911154568195,
0.010409804992377758,
-0.01516910269856453,
-0.012591532431542873,
-0.0357029102742672,
0.02395574375987053,
-0.023988185450434685,
-0.005381778348237276,
-0.016795579344034195,
-0.002911052666604519,
-0.0072611356154084206,
-0.02035946026444435,
-0.001983090303838253,
0.011177824810147285,
-0.007162097841501236,
-0.0014745444059371948,
0.009786497801542282,
0.074870266020298,
0.00019033183343708515,
0.030710984021425247,
-0.0007861288031563163,
0.028233543038368225,
0.02453586272895336,
0.011339357122778893,
0.0026837941259145737,
0.005551669746637344,
-0.0029688412323594093,
0.04527070373296738,
0.05339553579688072,
-0.022801881656050682,
0.010933424346148968,
-0.004143118392676115,
0.00982053391635418,
0.007597296964377165,
-0.00895844865590334,
-0.004322793334722519,
-0.08097760379314423,
-0.01020963303744793,
0.02369389496743679,
-0.030674494802951813,
0.016644135117530823,
-0.016280069947242737,
-0.005031689535826445,
0.003081417642533779,
-0.015446338802576065,
0.036964502185583115,
-0.0016304315067827702,
0.02204987406730652,
-0.007372151128947735,
0.005552070681005716,
-0.006042219698429108,
0.0011853985488414764,
0.003083552699536085,
0.010140638798475266,
-0.016368351876735687,
0.01718888059258461,
-0.02628006413578987,
0.0013571325689554214,
0.0003000665456056595,
0.0015125693753361702,
0.01770688034594059,
-0.017822833731770515,
-0.005712480284273624,
-0.03272412344813347,
0.05964586138725281,
0.018269814550876617,
0.011133052408695221,
-0.021717581897974014,
0.006143984850496054,
-0.014475981704890728,
0.012491692788898945,
-0.03532984480261803,
0.0026819175109267235,
-0.03821655362844467,
-0.01139018777757883,
0.0035533024929463863,
-0.0000024228356778621674,
0.02375822141766548,
0.0048630936071276665,
0.011523907072842121,
0.013832930475473404,
0.025854401290416718,
0.012489724904298782,
0.02430122345685959,
0.011795459315180779,
-0.007860172539949417,
-0.03033311292529106,
-0.017343301326036453,
0.040255866944789886,
0.01460406556725502,
-0.004978284705430269,
-0.009502792730927467,
0.011080542579293251,
-0.001255242619663477,
-0.009262250736355782,
-0.014945626258850098,
0.003375460859388113,
0.03327593579888344,
0.018106285482645035,
0.002207679208368063,
-0.02938937395811081,
-0.009250344708561897,
0.018843576312065125,
-0.022511672228574753,
-0.03132828325033188,
0.016061505302786827,
-0.01821725443005562,
-0.033339567482471466,
0.02961166389286518,
-0.008325761184096336,
-0.01647884026169777,
-0.0020022448152303696,
-0.012504597194492817,
-0.0010913271689787507,
0.034129902720451355,
0.020311547443270683,
-0.0036072637885808945,
0.016942039132118225,
0.006427840795367956,
-0.012669207528233528,
-0.010061807930469513,
0.0037928291130810976,
0.011589794419705868,
0.005533727817237377,
0.013883777894079685,
-0.019767306745052338,
0.007488558068871498,
-0.0085047148168087,
-0.007073430810123682,
0.008851375430822372,
0.009479271247982979,
-0.0021380926482379436,
-0.005821185186505318,
0.008746420964598656,
-0.009839789941906929,
0.00915142334997654,
0.00035571493208408356,
-0.00046360702253878117,
-0.019279994070529938,
-0.006975930649787188,
-0.03169998526573181,
0.018795158714056015,
0.008378338068723679,
-0.018816279247403145,
-0.024128012359142303,
-0.016726888716220856,
-0.003705323673784733,
0.004310124553740025,
0.0005216344725340605,
0.0035542899277061224,
0.01084668654948473,
0.024455534294247627,
-0.00549723207950592,
-0.021811870858073235,
0.07077062129974365,
-0.009222159162163734,
0.0019944559317082167,
-0.012858453206717968,
0.024109750986099243,
-0.026835478842258453,
0.0237266905605793,
-0.009062444791197777,
-0.02574152871966362,
-0.008844703435897827,
0.01545749418437481,
-0.048788152635097504,
-0.02556930109858513,
0.004020336549729109,
-0.010562519542872906,
-0.016320623457431793,
0.020640453323721886,
0.015496119856834412,
0.03438121825456619,
0.013100204057991505,
0.013415055349469185,
0.0137102035805583,
-0.021160930395126343,
0.03446232154965401,
0.023467451333999634,
-0.020575786009430885,
0.007075962610542774,
-0.01749967411160469,
-0.01049877516925335,
0.0053421007469296455,
0.023289067670702934,
-0.008035324513912201,
-0.0048136357218027115,
-0.003586905775591731,
0.022838734090328217,
-0.020289314910769463,
-0.03219436854124069,
0.007932906970381737,
0.003997505642473698,
-0.013757904060184956,
0.00014113273937255144,
-0.014055119827389717,
-0.014585663564503193,
0.020890768617391586,
-0.03520887717604637,
-0.005611174739897251,
-0.00754557317122817,
-0.010824967175722122,
-0.011310651898384094,
0.013464285992085934,
0.006804080680012703,
0.0229157954454422,
0.009266604669392109,
0.029810650274157524,
-0.012216165661811829,
0.031486496329307556,
-0.01386746671050787,
0.01458167564123869,
0.019864801317453384,
0.008495423011481762,
-0.006228126585483551,
-0.027385428547859192,
0.007748332340270281,
-0.005953521467745304,
0.02336934208869934,
-0.0012673247838392854,
-0.030310282483696938,
0.0007164734997786582,
-0.05697433650493622,
-0.019465399906039238,
0.023032138124108315,
-0.009846548549830914,
0.008570913225412369,
-0.0051986705511808395,
-0.051918137818574905,
-0.017522554844617844,
-0.02270250767469406,
-0.00871856976300478,
-0.0072224438190460205,
-0.030235789716243744,
0.008231568150222301,
-0.040768980979919434,
-0.019904933869838715,
-0.010006560944020748,
-0.029398620128631592,
0.002722539473325014,
-0.02200755663216114,
-0.0737917572259903,
-0.007241067010909319,
0.011375810019671917,
-0.012740087695419788,
0.018402352929115295,
-0.02873099222779274,
-0.01713147759437561,
0.01224126759916544,
-0.0435207337141037,
-0.010757103562355042,
-0.05580700561404228,
-0.027643628418445587,
0.000902379397302866,
0.004417463205754757,
0.02192210592329502,
0.014179475605487823,
-0.030803367495536804,
-0.011300476267933846,
-0.031863026320934296,
-0.009106650948524475,
-0.047387830913066864,
0.012830516323447227,
-0.06251445412635803,
0.022234652191400528,
0.021715905517339706,
-0.07954767346382141,
-0.030751531943678856,
-0.0002046944573521614,
-0.0026219720020890236,
0.004390622489154339,
-0.028429744765162468,
0.017247382551431656,
-0.0240156389772892,
-0.012619717046618462,
-0.019535135477781296,
-0.00869184359908104,
-0.01278290431946516,
-0.001987697556614876,
-0.013262292370200157,
0.00212325737811625,
-0.014522556215524673,
0.006339697632938623,
-0.015435857698321342,
0.03305305913090706,
0.007060115225613117,
0.059643760323524475,
0.02023659646511078,
-0.009041796438395977,
0.0038825394585728645,
-0.022648662328720093,
-0.022935030981898308,
-0.016550425440073013,
0.0030195987783372402,
0.029920974746346474,
0.008427305147051811,
-0.01782139390707016,
-0.01195719838142395,
0.011232913471758366,
0.03649105876684189,
0.04543809965252876,
-0.013500060886144638,
0.02210024558007717,
-0.018609121441841125,
-0.014647956937551498,
0.01665804535150528,
-0.00975798163563013,
0.0022471509873867035,
-0.009035480208694935,
0.028849638998508453,
0.00048681115731596947,
-0.039221689105033875,
0.014233429916203022,
-0.01018869411200285,
0.03322964534163475,
-0.008995180949568748,
-0.007409117184579372,
0.00904642790555954,
-0.0050331465899944305,
-0.02228766493499279,
-0.01832570880651474,
0.009542616084218025,
-0.004056570585817099,
0.012808745726943016,
-0.002200216520577669,
0.023758849129080772,
-0.008691573515534401,
-0.007293282076716423,
0.01307664904743433,
0.07035402953624725,
-0.04723893851041794,
0.020015237852931023,
-0.009177612140774727,
-0.022901684045791626,
0.004008485935628414,
-0.015482664108276367,
-0.005691795609891415,
-0.014899483881890774,
-0.040645383298397064,
0.009709905833005905,
-0.0001478111371397972,
-0.009605338796973228,
0.011791054159402847,
0.01780707575380802,
0.001956981373950839,
0.01943017728626728,
-0.023598145693540573,
-0.03957919031381607,
0.020236974582076073,
-0.022446218878030777,
-0.026428520679473877,
-0.010581576265394688,
-0.007702738977968693,
0.014718377031385899,
-0.007019476033747196,
-0.04619600623846054,
0.0073683978989720345,
-0.02824563719332218,
0.0013624646235257387,
0.00554794492200017,
0.0025112461298704147,
0.006003905087709427,
-0.048779696226119995,
0.0006524999625980854,
-0.00946645438671112,
-0.00674795126542449,
0.0033871911000460386,
0.01587841846048832,
0.021110136061906815,
0.0021788999438285828,
-0.006404138635843992,
-0.003939265850931406,
-0.013687873259186745,
0.03733286261558533,
-0.031116168946027756,
-0.013970081694424152,
0.000619247555732727,
-0.008662240579724312,
0.023989148437976837,
0.005921770818531513,
0.016230925917625427,
0.04428704455494881,
-0.06463903188705444,
-0.009601308032870293,
0.03585708513855934,
-0.002813100814819336,
0.028693486005067825,
0.010773290880024433,
-0.009542380459606647,
0.009543118067085743,
-0.02942195162177086,
-0.007242681924253702,
-0.023144669830799103,
0.019733641296625137,
-0.03978276997804642,
0.011835691519081593,
-0.011741520836949348,
-0.017254788428544998,
0.007557729259133339,
-0.001080206362530589,
0.03176576644182205,
0.007279161363840103,
-0.020730026066303253,
0.028813589364290237,
-0.004633147269487381,
0.039019182324409485,
-0.0033713376615196466,
0.028770683333277702,
0.008247630670666695,
-0.02448541671037674,
-0.03315486013889313,
-0.0019302191212773323,
0.0064140670001506805,
-0.03167599439620972,
-0.0077200960367918015,
0.0020447787828743458,
-0.03353855758905411,
-0.01996609941124916,
0.0075327069498598576,
-0.012287115678191185,
0.01178942620754242,
0.0014003687538206577,
0.006463575176894665,
0.011079004965722561,
0.036387849599123,
-0.010306362994015217,
0.011304154060781002,
0.004894656129181385,
0.014599052257835865,
-0.013261165469884872,
0.0020250300876796246,
0.01804562471807003,
0.01717977598309517,
-0.022933723405003548,
-0.02271309494972229,
0.011367923580110073,
0.013890344649553299,
-0.017719484865665436,
-0.01362605020403862,
-0.015556568279862404,
0.0010530265280976892,
0.033333975821733475,
-0.021739516407251358,
0.01397220604121685,
-0.016912322491407394,
-0.00980526302009821,
0.0177739467471838,
0.01731438934803009,
-0.009667033329606056,
-0.008529353886842728,
-0.006853087805211544,
-0.02532636933028698,
0.04181160032749176,
-0.029957976192235947,
-0.020920248702168465,
-0.0013788568321615458,
0.003097990993410349,
-0.00770620396360755,
0.016266604885458946,
0.001362387090921402,
-0.004820540547370911,
0.0007467702962458134,
0.012899466790258884,
0.02121312916278839,
0.015552702359855175,
0.0034657283686101437,
-0.028448792174458504,
0.030526531860232353,
0.011016546748578548,
-0.0011140345595777035,
-0.012789491564035416,
-0.00005813920870423317,
-0.014544276520609856,
0.011392941698431969,
0.020319998264312744,
0.010215839371085167,
-0.0015068559441715479,
0.017317241057753563,
0.025044232606887817,
-0.009656347334384918,
0.005051940213888884,
0.005410490091890097,
-0.007774517871439457,
-0.01906760409474373,
0.006710812449455261,
-0.00228682067245245,
-0.015999242663383484,
-0.01707199588418007,
0.0016780942678451538,
-0.01258693914860487,
0.006876604165881872,
0.003919803537428379,
0.03359178081154823,
0.005199198145419359,
-0.0049263350665569305,
0.009266693145036697,
0.005660089664161205,
-0.014223527163267136,
-0.016821060329675674,
-0.018490467220544815,
-0.015499874949455261,
-0.015500813722610474,
0.011378038674592972,
-0.012249779887497425,
-0.02360183745622635,
-0.014633357524871826,
-0.009596980176866055,
-0.004002515226602554,
0.020020511001348495,
0.03210999071598053,
-0.01715381070971489,
0.0009130788967013359,
-0.013142636977136135,
0.0059541938826441765,
0.03094024583697319,
-0.014101768843829632,
0.021478842943906784,
0.024426491931080818,
-0.03774619475007057,
0.009211044758558273,
-0.027143290266394615,
-0.014892317354679108,
0.013108767569065094,
-0.013443142175674438,
0.01144104078412056,
0.00965385977178812,
-0.012628240510821342,
-0.0140073262155056,
0.0008343036752194166,
-0.003228271845728159,
0.007291004061698914
] | [
0.6371421217918396,
0.12330105155706406,
-0.26897233724594116,
0.21204020082950592,
0.43351924419403076,
-0.0027490330394357443,
-0.07072010636329651,
0.18945565819740295,
-0.4689050614833832,
-0.6217517256736755,
0.09282294660806656,
0.03823423013091087,
-0.3533300757408142,
0.05269036069512367,
0.08284229785203934,
0.2222920060157776,
0.3888598084449768,
0.42525193095207214,
-0.18733713030815125,
-0.6293653249740601,
-0.4942172169685364,
-0.1591499298810959,
0.13384480774402618,
-0.07331108301877975,
0.13580778241157532,
-0.49829381704330444,
0.08905728161334991,
0.22166317701339722,
0.11920080333948135,
-0.10621435940265656,
-0.07747458666563034,
0.4066179692745209,
0.11939461529254913,
-0.16594848036766052,
0.09561032801866531,
-0.2336825281381607,
0.11842399835586548,
0.008348367176949978,
-0.21701684594154358,
-0.48168525099754333,
-0.4324522018432617,
0.1596737951040268,
0.1461024433374405,
0.16374385356903076,
0.016997264698147774,
-0.7645664215087891,
-1.118919014930725,
0.1721726357936859,
-0.17913641035556793,
0.10657995194196701,
0.3454534411430359,
0.23558561503887177,
0.13163964450359344,
0.30229124426841736,
0.09051153063774109,
0.42075493931770325,
-0.35409823060035706,
0.0803685113787651,
0.11639498174190521,
-0.4807921350002289,
0.47401297092437744,
0.13503244519233704,
-0.029076863080263138,
0.13010917603969574,
0.14721952378749847,
0.24156728386878967,
0.4614751935005188,
-0.08815982937812805,
0.05312629044055939,
-0.12014744430780411,
0.09548009186983109,
-0.31703364849090576,
-0.09673058241605759,
0.1568138152360916,
-0.12701508402824402,
-0.06634822487831116,
0.11525649577379227,
-0.20439109206199646,
0.03410430625081062,
0.07026416808366776,
-0.07495754212141037,
0.029473165050148964,
0.10604771226644516,
-0.1857246458530426,
0.545209527015686,
0.1595611274242401,
-0.34044116735458374,
0.5545963048934937,
-0.37909629940986633,
0.013352176174521446,
0.031993914395570755,
-0.02967085689306259,
0.2105254977941513,
0.5345067381858826,
-0.18481993675231934,
-0.006115697789937258,
0.2680770456790924,
-0.2668479084968567,
0.180372953414917,
-0.15544508397579193,
-0.44146472215652466,
-0.11497317999601364,
0.3481489419937134,
-0.014859724789857864,
0.16940028965473175,
-0.30979642271995544,
-0.38317176699638367,
0.2484705001115799,
-0.3826403021812439,
0.4827559292316437,
-0.4153580665588379,
-0.17872492969036102,
-0.2026747167110443,
-0.06187637895345688,
-0.7823270559310913,
0.10094700753688812,
-0.10434696078300476,
-0.4450114071369171,
0.10432278364896774,
-0.06982562690973282,
-0.1571294069290161,
1.1938211917877197,
-0.22891370952129364,
-0.04759940132498741,
-0.10206151753664017,
0.1625022143125534,
0.7345269918441772,
0.1809157431125641,
-0.4159797430038452,
0.538356602191925,
0.016478704288601875,
0.5789322257041931,
-0.4862150251865387,
0.23215699195861816,
-0.12504296004772186,
0.1428873986005783,
-0.061376556754112244,
0.7158810496330261,
0.37747591733932495,
-0.23659327626228333,
-0.6857832074165344,
-0.8575048446655273,
-0.380275696516037,
0.32554754614830017,
0.09246141463518143,
-0.015898622572422028,
-0.11896513402462006,
-0.13360682129859924,
-0.2733004689216614,
-0.22607897222042084,
-0.24235683679580688,
-0.08635925501585007,
-0.7628222703933716,
0.04151061549782753,
0.004128508269786835,
0.359245628118515,
0.16482631862163544,
-0.12001192569732666,
-0.3049284815788269,
0.09007390588521957,
0.3690311312675476,
0.24702543020248413,
-0.4595594108104706,
-0.20611467957496643,
0.2236204594373703,
0.05120687559247017,
-0.07064571231603622,
0.5382688045501709,
-0.21139608323574066,
-0.36691024899482727,
-0.25541698932647705,
-0.08753196150064468,
-0.25958511233329773,
-0.6665613651275635,
-0.16441120207309723,
0.4548274874687195,
0.160654217004776,
0.132533997297287,
0.17072933912277222,
0.5706004500389099,
-0.783042848110199,
0.263101190328598,
-0.3780759572982788,
-0.8873835802078247,
-0.006459159776568413,
-0.18059489130973816,
0.12342914193868637,
0.16470755636692047,
-0.206450954079628,
-0.38043731451034546,
-0.3898715674877167,
-0.498277872800827,
0.44436466693878174,
-0.7726420164108276,
0.8468713164329529,
-0.4103521406650543,
0.10595062375068665,
1.5240581035614014,
0.1778709441423416,
0.3013741075992584,
0.16061188280582428,
0.6885480880737305,
0.17802533507347107,
-0.32830700278282166,
-0.4558471739292145,
0.47252222895622253,
0.2762886583805084,
-0.0712973028421402,
-0.16453927755355835,
-0.000840187247376889,
0.9019333124160767,
0.06235113367438316,
0.05097590759396553,
-0.2723674178123474,
0.48369497060775757,
-0.14228154718875885,
-0.4028210937976837,
0.28362178802490234,
-0.2589495778083801,
0.226152241230011,
0.5078919529914856,
-0.29976436495780945,
0.16675865650177002,
0.4118408262729645,
0.2542799115180969,
0.7443063259124756,
0.48662620782852173,
0.17906315624713898,
0.7050992250442505,
-0.6848695874214172,
0.06048107147216797,
-0.14848189055919647,
0.08793028444051743,
-0.6928501725196838,
-0.5476033091545105,
0.26363345980644226,
0.05331573262810707,
0.10138466209173203,
0.10548074543476105,
0.49551233649253845,
-0.002875272650271654,
0.2634049355983734,
-0.9853492975234985,
0.3120487928390503,
-0.2641216218471527,
-0.5292173027992249,
-0.3218576908111572,
-0.18732501566410065,
-0.587403416633606,
-0.224028542637825,
0.1379968672990799,
0.5309553146362305,
0.022624239325523376,
-0.4593862295150757,
0.04940410330891609,
0.028025221079587936,
-0.2613825500011444,
-0.018402470275759697,
0.3824056088924408,
-0.4243695139884949,
0.1663401871919632,
0.44100815057754517,
0.4022843539714813,
0.5049222111701965,
-0.15630660951137543,
-0.49609866738319397,
-0.9115337133407593,
-0.3361670970916748,
0.7776370644569397,
0.8021586537361145,
0.8040815591812134,
-0.5224171876907349,
-0.5436325669288635,
0.07284392416477203,
-0.06557196378707886,
-0.47365865111351013,
0.22959579527378082,
1.0885852575302124,
-0.46598413586616516,
-0.14102618396282196,
0.046934742480516434,
0.20640717446804047,
0.7703301310539246,
-0.4180043935775757,
0.25617557764053345,
-0.2300708293914795,
0.023597432300448418,
-0.005499375052750111,
-0.5662238001823425,
-0.2883322536945343,
-0.03352245315909386,
-0.07138513028621674,
-0.06675278395414352,
-0.21723969280719757,
0.6119799613952637,
0.5684568881988525,
0.24451038241386414,
0.5085766315460205,
0.33895930647850037,
-0.5269474387168884,
-0.1842798888683319,
0.5517948269844055,
-0.28023219108581543,
-0.27702999114990234,
-0.005047230515629053,
0.18513178825378418,
-0.43292924761772156,
-0.20014874637126923,
-6.115062236785889,
0.41713035106658936,
-0.2801609933376312,
-0.28666651248931885,
-0.3347821831703186,
-0.10300511866807938,
0.6643735766410828,
-0.2295754849910736,
0.3045557141304016,
-0.19138376414775848,
0.4668864905834198,
0.403334379196167,
0.0027468870393931866,
-0.08838430792093277,
-0.2801133096218109,
0.3183724582195282,
0.31667691469192505,
-0.005527239292860031,
0.18667027354240417,
0.40949711203575134,
-0.37070465087890625,
-0.02282087691128254,
0.2038048505783081,
0.4560357928276062,
0.5166113376617432,
0.05866112932562828,
-0.9379984140396118,
0.4000840187072754,
-0.2171684354543686,
0.30063486099243164,
0.32980936765670776,
-0.413273423910141,
0.024807767942547798,
-0.3983556628227234,
0.18998922407627106,
-0.04371771216392517,
-0.03480848670005798,
-0.21850521862506866,
0.36216291785240173,
0.06480298191308975,
-0.3701385259628296,
0.26396188139915466,
-0.34089693427085876,
-0.16469866037368774,
0.05485941842198372,
-0.34936776757240295,
-0.013681192882359028,
0.23801158368587494,
0.25192326307296753,
0.8460922241210938,
-0.06655862927436829,
0.05450435355305672,
0.32600170373916626,
0.49395278096199036,
0.10019043833017349,
-0.21196988224983215,
-0.01996641792356968,
0.195531964302063,
-0.3882872760295868,
0.10911581665277481,
-0.04882785677909851,
-0.16918399930000305,
0.17317596077919006,
-0.4807174801826477,
0.16772127151489258,
0.19956079125404358,
-0.3401035666465759,
-0.37464237213134766,
0.163035050034523,
-0.37620285153388977,
-0.23703919351100922,
0.057700302451848984,
0.48400136828422546,
-0.4266435205936432,
0.1659947633743286,
-0.6930619478225708,
-0.13001315295696259,
0.1794203519821167,
0.20339468121528625,
-0.2789631187915802,
0.07024989277124405,
-0.12626293301582336,
0.0024189918767660856,
-0.5647628307342529,
0.16723757982254028,
-0.21383114159107208,
0.07572362571954727,
0.13465899229049683,
-0.3361915051937103,
0.42714259028434753,
0.9810321927070618,
-0.5361342430114746,
0.18441906571388245,
0.49066588282585144,
0.16082803905010223,
0.40825051069259644,
0.03691690042614937,
-0.21779127418994904,
0.7712322473526001,
-0.21114417910575867,
0.41186773777008057,
-0.26254528760910034,
-0.45654135942459106,
-0.6349940299987793,
-0.13408569991588593,
-0.01840074732899666,
-0.03990759328007698,
0.11291234195232391,
0.8459740281105042,
-0.7175893783569336,
0.35713982582092285,
0.07917504012584686,
-0.16732750833034515,
-0.32051193714141846,
0.4136382043361664,
-0.13511908054351807,
0.11545936018228531,
0.26488593220710754,
0.3730680048465729,
-0.4221290946006775,
0.5952507853507996,
-0.045426927506923676,
-0.4582110047340393,
0.6718307733535767,
-0.03824184462428093,
0.19852939248085022,
0.1974291205406189,
0.7048662900924683,
-0.40415480732917786,
-0.32920002937316895,
0.09793191403150558,
0.5766080021858215,
-0.018341844901442528,
0.16187795996665955,
0.16939842700958252,
-0.5405723452568054,
-0.012033230625092983,
-0.1775396466255188,
0.39598289132118225,
-0.2986655831336975,
0.05870535969734192,
-0.036597881466150284,
-0.32283833622932434,
-0.18432006239891052,
0.15935440361499786,
0.41638684272766113,
-0.3890201151371002,
0.06869159638881683,
0.14299741387367249,
-0.23557129502296448,
0.02058054879307747,
-0.06876026093959808,
0.15858767926692963,
0.18411456048488617,
-0.7660434246063232,
-0.04165305569767952,
0.6741736531257629,
-0.17678090929985046,
-0.011693771928548813,
-0.14721477031707764,
1.0757725238800049,
0.3132055401802063,
-0.8751737475395203,
-0.0824350044131279,
0.181421160697937,
-0.2643861174583435,
0.41492944955825806,
-0.5221644043922424,
-0.3570035398006439,
0.22289256751537323,
-0.17428098618984222,
-0.6788928508758545,
-0.3596974015235901,
0.021653437986969948,
0.3396064341068268,
0.2239556461572647,
-0.48598822951316833,
0.2927924692630768,
0.20110850036144257,
0.21138149499893188,
-0.13864998519420624,
-0.4930787980556488,
-0.6028028130531311,
0.3175628185272217,
0.34167274832725525,
0.38103070855140686,
0.2672317624092102,
-0.13926486670970917,
-0.29248544573783875,
-0.4966846704483032,
-0.025193415582180023,
0.5012064576148987,
0.2113519310951233,
0.17894648015499115,
0.23969589173793793,
-0.3749364912509918,
-0.012999163009226322,
0.33990389108657837,
-0.21033959090709686,
0.08629971742630005,
0.03937096893787384,
0.29264381527900696,
-0.27450689673423767,
0.4053661823272705,
0.0869259312748909,
0.05135706439614296,
0.27898696064949036,
0.29667267203330994,
0.30662772059440613,
-0.26808446645736694,
-0.23881739377975464,
-0.7735388278961182,
-0.3553627133369446,
0.5876984000205994,
-0.3167210519313812,
0.47303393483161926,
-0.002018988598138094,
-0.10683140903711319,
-0.27667516469955444,
0.2541896104812622,
0.23815235495567322,
0.06519623845815659,
-0.5203384757041931,
-0.3558606803417206,
-0.42910531163215637,
0.5854012966156006,
0.3271228075027466,
-0.7437601089477539,
-0.28096240758895874,
-0.14134812355041504,
-0.6907077431678772,
-0.014736142009496689,
0.025128651410341263,
0.18294602632522583,
-0.8988760709762573,
-0.03496089205145836,
0.07187484204769135,
-0.36364829540252686,
0.1343294084072113,
-0.022656220942735672,
0.11115248501300812,
0.6077198386192322,
0.0008569403435103595,
-0.6567375063896179,
-0.2627972662448883,
0.6220076084136963,
0.22394002974033356,
-0.6696778535842896,
-0.20359614491462708,
-0.19429995119571686,
0.1627204567193985,
-0.4644465744495392,
-0.14618276059627533,
0.08602489531040192,
0.38650450110435486,
0.14622418582439423,
-0.3945016860961914,
-0.042441390454769135,
-0.10767099261283875,
-0.03807492181658745,
-0.01503235474228859,
-0.26916050910949707,
-0.4585086703300476,
-0.37508097290992737,
-0.006038106977939606,
-0.024913376197218895,
-0.40641647577285767,
0.005740565713495016,
-0.19069159030914307,
-0.5535236597061157,
0.06420134752988815,
0.02317654713988304,
0.43010202050209045,
0.10215754061937332,
0.3153976798057556,
0.318593829870224,
0.033032964915037155,
0.1117001473903656,
-0.38702061772346497,
0.7905111908912659,
-0.46683502197265625,
-0.8731809258460999,
-0.034891724586486816,
-0.4939451813697815,
0.3238498568534851,
0.028205156326293945,
0.20410822331905365,
0.0044806841760873795,
0.018367506563663483,
-0.47030457854270935,
-0.02957431972026825,
0.15730448067188263,
-0.7201340794563293,
-0.28907227516174316,
0.06702026724815369,
-0.009727384895086288,
0.4581921100616455,
0.39879298210144043,
0.45924076437950134,
-0.6271601915359497,
-0.5466999411582947,
0.4337344169616699,
0.01330588385462761,
-0.5700451731681824,
0.4696601331233978,
-0.14822480082511902,
0.04576922953128815,
-0.224781334400177,
0.07044047117233276,
0.34837082028388977,
0.494002103805542,
-0.1339229941368103,
-0.13895408809185028,
0.5780762434005737,
-0.10215363651514053,
0.08816050738096237,
-0.014360841363668442,
-0.4735107719898224,
0.5919232368469238,
0.11690822243690491,
0.0030787233263254166,
0.28672540187835693,
0.34638872742652893,
-0.40755975246429443,
-0.3963986337184906,
0.1512492150068283,
-0.31089115142822266,
0.05428285896778107,
-0.31039273738861084,
0.18792888522148132,
0.6632902026176453,
0.8735925555229187,
-0.10722145438194275,
0.13006360828876495,
0.2397618442773819,
0.29489976167678833,
0.3921738862991333,
-0.7722699046134949,
-0.2651916444301605,
-0.3255563974380493,
0.5986620783805847,
0.22352507710456848,
0.1026739627122879,
-0.2729067802429199,
-0.08698549121618271,
0.2500649392604828,
0.07045705616474152,
0.5592169165611267,
-0.3434355854988098,
0.18040195107460022,
0.03707034885883331,
0.2769574820995331,
-0.1209067702293396,
0.034249093383550644,
0.1596883237361908,
0.033606965094804764,
0.29856380820274353,
-0.16302931308746338,
-0.6072424054145813,
0.45190179347991943,
0.1107759177684784,
0.497515469789505,
0.06733472645282745,
0.364914208650589,
-0.14378109574317932,
-0.301841139793396,
0.25642362236976624,
0.04280282184481621,
0.2499711662530899,
-0.33697420358657837,
-0.3142748475074768,
-0.21436245739459991,
-0.8418100476264954,
0.26651179790496826,
0.14743174612522125,
0.0005165612092241645,
-0.2232038825750351,
0.20188039541244507,
-0.2629643380641937,
0.4835004508495331,
-0.3100486397743225,
-0.1096351370215416,
-0.22541466355323792,
-0.15465925633907318,
0.11106932908296585,
0.04872638359665871,
-0.18993885815143585,
0.10277041047811508,
0.3560636341571808,
0.21586409211158752,
-0.20796173810958862,
-0.650343656539917,
-0.3668135106563568,
0.4428798258304596,
0.1573709398508072,
-0.042958881705999374,
-0.38357168436050415,
0.5202204585075378,
0.02853335812687874,
0.21653088927268982,
-0.13999901711940765,
0.21465155482292175,
-0.3718010485172272,
0.2764413058757782,
-0.32722824811935425,
0.3143181800842285,
-0.7959977388381958,
0.1456601619720459,
-0.9177572131156921,
0.1195506900548935,
0.4482114613056183,
0.2546830475330353,
-0.46198946237564087,
-0.02708081156015396,
0.23687168955802917,
0.21308887004852295,
0.10220678895711899,
-0.18908438086509705,
0.17635571956634521,
-0.265823632478714,
-0.5646994709968567,
-0.425427109003067,
0.14470593631267548,
-0.2964877188205719,
0.008692121133208275,
-0.41618913412094116,
-0.08230124413967133,
0.8210414052009583,
-0.39139771461486816,
0.6589716076850891,
-0.09183835238218307,
-0.12029742449522018,
-0.7797310948371887,
0.32826119661331177,
-0.4467669427394867,
0.1673881560564041,
0.198215052485466,
0.5292989611625671,
0.4808146357536316,
-0.05518889054656029,
0.5323652625083923,
-0.07047893851995468,
0.2271961271762848,
0.1298670470714569,
0.21438905596733093,
-0.30684685707092285,
0.06319606304168701,
-0.29570022225379944,
-0.6019001603126526,
0.5728477835655212,
0.015803057700395584,
-0.22857682406902313,
0.2777370512485504,
-0.23450560867786407,
-0.18611907958984375,
0.2914182245731354,
0.03301871195435524,
-0.33997413516044617,
0.09318505227565765,
-0.20192861557006836
] |
[
0.030699975788593292,
0.10140369832515717,
-0.04192632809281349,
0.06293141841888428,
-0.03267847001552582,
-0.12038351595401764,
0.035765983164310455,
-0.05915536358952522,
-0.008488839492201805,
-0.05911063775420189,
-0.05657084658741951,
-0.005575065966695547,
-0.05070307105779648,
0.06654473394155502,
-0.05232572928071022,
-0.10524960607290268,
-0.11025319993495941,
0.10980250686407089,
0.11460278183221817,
-0.11366231739521027,
-0.0736834928393364,
-0.014200853183865547,
0.03315950185060501,
-0.042415086179971695,
-0.18886972963809967,
0.04834016412496567,
-0.010257190093398094,
-0.013155662454664707,
-0.11621294915676117,
0.22128282487392426,
0.026432644575834274,
-0.0035340951289981604,
0.09944672882556915,
0.0506606251001358,
0.07618589699268341,
-0.1337132453918457,
-0.07806193083524704,
0.018981769680976868,
-0.056862808763980865,
-0.14643901586532593,
-0.16388945281505585,
-0.057634275406599045,
0.07937344908714294,
-0.0544847771525383,
-0.024052107706665993,
-0.07310523092746735,
-0.07155387103557587,
-0.10090649873018265,
-0.028452187776565552,
0.14460046589374542,
-0.05908972769975662,
-0.0028850892558693886,
-0.030829090625047684,
-0.06325825303792953,
-0.02312028780579567,
-0.15990810096263885,
-0.09092682600021362,
-0.016466086730360985,
0.06645786762237549,
0.04531364515423775,
-0.11512433737516403,
0.10278821736574173,
-0.23874814808368683,
-0.08993463963270187,
0.04214683547616005,
-0.06208702549338341,
0.19159553945064545,
0.06058281660079956,
0.04147198423743248,
0.04145164415240288,
0.08241380751132965,
0.07910601049661636,
-0.21460114419460297,
-0.04764945060014725,
-0.06004532054066658,
-0.05771621689200401,
0.04311008378863335,
0.029352186247706413,
-0.007787349633872509,
0.0667465552687645,
0.11730451881885529,
-0.036040034145116806,
0.0379948653280735,
0.08618149906396866,
0.09119251370429993,
-0.12663358449935913,
-0.027850864455103874,
-0.026794370263814926,
0.10444615036249161,
-0.19966867566108704,
-0.06711355596780777,
0.020024478435516357,
0.02054487355053425,
-0.07212473452091217,
-0.12159039080142975,
-0.23648804426193237,
-0.04011392965912819,
0.10453135520219803,
-0.08162038028240204,
-0.047898195683956146,
-0.14109919965267181,
-0.09871640801429749,
0.006453124340623617,
0.08454540371894836,
-0.20008768141269684,
0.031001994386315346,
0.3166082501411438,
-0.08357764780521393,
-0.06154737249016762,
0.05468873679637909,
-0.10438451170921326,
-0.043026577681303024,
0.039880186319351196,
-0.002967559266835451,
0.04125188663601875,
0.10730873048305511,
-0.031131744384765625,
0.07599066942930222,
0.11015765368938446,
0.2026078850030899,
0.0340835340321064,
-0.11498764902353287,
0.00341621832922101,
0.1823115050792694,
0.08721653372049332,
0.08886470645666122,
0.038886621594429016,
-0.14626866579055786,
-0.10826382040977478,
-0.10755138099193573,
-0.043079130351543427,
0.06791600584983826,
-0.08626728504896164,
-0.13008858263492584,
-0.06684456765651703,
-0.0757908821105957,
-0.12930254638195038,
0.10704216361045837,
-0.16803321242332458,
0.12600107491016388,
-0.04051733389496803,
0.056915540248155594,
0.09876076132059097,
0.05756385996937752,
0.12005363404750824,
-0.09532523900270462,
-0.0735682025551796,
0.04351639747619629,
0.12305520474910736,
-0.12239664793014526,
-0.03981996327638626,
-0.02161284163594246,
-0.10828825831413269,
-0.0646689310669899,
-0.03846750035881996,
0.19904725253582,
-0.03407208248972893,
-0.10436071455478668,
0.018596051260828972,
0.10414863377809525,
0.09536723792552948,
-0.014020226895809174,
0.04361536353826523,
0.028888408094644547,
-0.06593406200408936,
0.008343683555722237,
0.04160940647125244,
-0.011753213591873646,
-0.11578797549009323,
0.05167029798030853,
-0.06676144897937775,
0.1441592276096344,
-0.22843779623508453,
0.12496988475322723,
0.028016896918416023,
-0.05906530097126961,
0.17457708716392517,
0.05070481076836586,
-0.11385047435760498,
0.060045935213565826,
-0.09621882438659668,
0.05438654124736786,
0.03432608023285866,
0.15427951514720917,
0.11706224828958511,
-0.002386678010225296,
0.00803310889750719,
-0.07359828799962997,
0.15835100412368774,
0.017626335844397545,
-0.007624693680554628,
-0.04966338351368904,
-0.04089459404349327,
0.07255762070417404,
0.21151596307754517,
0.06603258103132248,
0.09396278113126755,
-0.018833069130778313,
0.02596215531229973,
0.07787297666072845,
0.0033172147814184427,
-0.03406890109181404,
-0.0378173291683197,
0.0016285512829199433,
0.17468418180942535,
0.14436595141887665,
0.07670074701309204,
-0.018170222640037537,
-0.12715241312980652,
0.011177051812410355,
0.04855913668870926,
0.05172306299209595,
-0.04483100771903992,
-0.031188545748591423,
0.21232262253761292,
-0.12014889717102051,
0.04454215243458748,
-0.006694146431982517,
-0.008590037934482098,
0.010534912347793579,
-0.005982778966426849,
-0.049038566648960114,
-0.03788432478904724,
-0.148992121219635,
-0.15680280327796936,
0.11952607333660126,
-0.03443474322557449,
-0.009466748684644699,
-0.17385894060134888,
0.06695250421762466,
-0.08063670247793198,
0.1111515536904335,
-0.05964672192931175,
-0.08919277042150497,
0.07400178909301758,
-0.08179539442062378,
0.010917145758867264,
-0.10002771019935608,
0.030084840953350067,
-0.05879339575767517,
0.15256229043006897,
-0.0588756687939167,
0.058464743196964264,
-0.06250129640102386,
-0.1272299885749817,
0.14816193282604218,
0.11261296272277832,
-0.20878300070762634,
0.07267408818006516,
-0.19025585055351257,
0.04558248072862625,
-0.06399069726467133,
0.09287825971841812,
-0.14967121183872223,
0.0832153856754303,
0.0884755551815033,
-0.07130222767591476,
-0.08636317402124405,
-0.062446922063827515,
-0.0917036235332489,
0.04213356599211693,
0.02685438096523285,
-0.07510712742805481,
0.14564858376979828,
-0.1311965137720108,
0.06008942797780037,
0.10980391502380371,
0.23106127977371216,
0.06301818042993546,
-0.11306808888912201,
0.4958252012729645,
-0.08599810302257538,
-0.10827255249023438,
-0.07431084662675858,
0.00557404151186347,
-0.010929758660495281,
0.19725823402404785,
0.07282532006502151,
0.12956568598747253,
0.12012496590614319,
-0.32143303751945496,
-0.003951505292207003,
0.031411223113536835,
0.2858768403530121,
0.007240592502057552,
-0.04573579132556915,
-0.15110504627227783,
-0.06919705122709274,
-0.05780123919248581,
0.045537661761045456,
0.08062059432268143,
0.05595998466014862,
-0.19111478328704834,
0.20023339986801147,
0.030304836109280586,
0.16707292199134827,
-0.019236214458942413,
0.14964352548122406,
-0.0109718581661582,
0.08966008573770523,
-0.1306983232498169,
-0.10273553431034088,
0.05057602375745773,
-0.10228367894887924,
-0.014037727378308773,
0.01175781711935997,
-0.19365377724170685,
0.07810384780168533,
-0.09055490046739578,
-0.024642886593937874,
-0.007601541467010975,
0.024362703785300255,
0.1254616379737854,
-0.048288214951753616,
0.038688793778419495,
-0.023422805592417717,
-0.039048850536346436,
0.09871713072061539,
-0.12935157120227814,
-0.08097562938928604,
-0.08026036620140076,
0.09477176517248154,
-0.016387617215514183,
0.016990656033158302,
-0.08228129148483276,
-0.013419480063021183,
0.09099746495485306,
-0.12665517628192902,
-0.11556627601385117,
-0.06357208639383316,
0.13796506822109222,
-0.03748014569282532,
-0.06792362779378891,
-0.11707259714603424,
-0.03880562260746956,
0.021529851481318474,
0.1335168182849884,
-0.20159269869327545,
-0.020768262445926666,
0.03235907480120659,
0.17776764929294586,
-0.13711069524288177,
0.054383035749197006,
0.1364498734474182,
-0.0664997398853302,
-0.13668900728225708,
-0.05714643374085426,
0.06318619847297668,
-0.04915833845734596,
-0.037615757435560226,
-0.030773334205150604,
0.16446112096309662,
-0.04886315017938614,
-0.18910305202007294,
0.07617077976465225,
-0.016795340925455093,
0.09917127341032028,
-0.018028702586889267,
0.17936013638973236,
0.1950056403875351,
-0.07366102188825607,
0.06003068387508392,
-0.06908491253852844,
0.010838094167411327,
-0.01070399209856987,
-0.02660319395363331,
0.013416670262813568,
-0.06685419380664825,
-0.02624829299747944,
-0.03683823347091675,
-0.09697310626506805,
-0.18608561158180237,
0.0381377749145031,
0.14146940410137177,
-0.1311713010072708,
0.07777606695890427,
-0.01577705889940262,
-0.17565688490867615,
0.03242841362953186,
0.033038247376680374,
-0.10881786793470383,
-0.11456996947526932,
-0.020494369789958,
0.029386846348643303,
0.09281162917613983,
0.1401824951171875,
0.15178707242012024,
0.040599074214696884,
0.09011775255203247,
-0.24185405671596527,
-0.048800211399793625,
0.0538560152053833,
0.024362187832593918,
0.08835064619779587,
-0.12078657001256943,
-0.029829923063516617,
-0.050800859928131104,
-0.027568737044930458,
0.11569537967443466,
-0.08833982795476913,
-0.07752125710248947,
0.04416066035628319,
0.10488185286521912,
-0.03403449431061745,
-0.036388035863637924,
-0.028469476848840714,
0.00013972366286907345,
-0.02620040997862816,
0.019505295902490616,
0.03172631934285164,
-0.009704504162073135,
-0.008721652440726757,
0.02358195185661316,
-0.02107628993690014,
0.10953398793935776,
-0.12684720754623413,
-0.011352095752954483,
0.20320820808410645,
0.11569026112556458,
0.06384299695491791,
0.07973365485668182,
0.07756686955690384,
-0.014700566418468952,
-0.07601739466190338,
-0.15688274800777435,
0.043123140931129456,
-0.07327551394701004,
0.11937576532363892,
-0.16742980480194092,
-0.06767740845680237,
-0.032997481524944305,
0.03229013830423355,
-0.07201521098613739,
0.020497772842645645,
0.1007266715168953,
0.10656307637691498,
-0.006670929957181215,
0.045204728841781616,
-0.11228744685649872,
0.03726661205291748,
-0.09642747044563293,
-0.021383125334978104,
0.09304244816303253,
0.16754911839962006,
0.046043168753385544,
-0.06674063950777054,
0.05671413242816925,
-0.1691814512014389,
-0.09079419821500778,
0.02362711913883686,
-0.03823481500148773,
0.032727308571338654,
0.027651354670524597,
-0.06272287666797638,
0.25346511602401733,
-0.0711563304066658,
-0.09735190868377686,
0.09871630370616913,
-0.09277880936861038,
0.17078223824501038,
-0.04301628842949867,
-0.12943820655345917,
0.09328215569257736,
-0.03212863951921463,
0.07257618755102158,
-0.0919959545135498,
-0.09690722078084946,
-0.014983730390667915,
-0.02383156679570675,
0.1599690020084381,
0.2708745300769806,
0.004232767503708601,
0.06919010728597641,
-0.18598918616771698,
-0.18889376521110535,
0.12317569553852081,
0.20423759520053864,
-0.018112223595380783,
0.05860372632741928,
0.04035134240984917,
0.23361057043075562,
-0.036147184669971466,
0.09624502807855606,
0.15925373136997223,
-0.05318930000066757,
0.0999671220779419,
-0.1810319870710373,
-0.05631474032998085,
0.24686497449874878,
-0.29344862699508667,
-0.08175241202116013,
-0.1502540409564972,
0.03189156949520111,
-0.21783162653446198,
-0.0316685251891613,
0.0770697370171547,
0.011430091224610806,
-0.20418010652065277,
0.12323997914791107,
-0.05420595780014992,
-0.06644335389137268,
0.017708318307995796,
-0.031245650723576546,
-0.069255530834198,
0.029646968469023705,
-0.010673110373318195,
-0.043574053794145584,
0.04528564214706421,
-0.010181069374084473,
0.17210781574249268,
-0.11144612729549408,
-0.03275112062692642,
-0.01416890136897564,
-0.11918938905000687,
0.16780740022659302,
-0.04347151517868042,
-0.07990653067827225,
-0.1383093297481537,
-0.07701651751995087,
0.13612787425518036,
0.06718118488788605,
-0.03026001900434494,
-0.10584010183811188,
0.1504666954278946,
0.04537953436374664,
-0.04277321323752403,
-0.07999415695667267,
-0.05302651226520538,
0.06232829764485359,
-0.06967832148075104,
0.006939463783055544,
0.03764990344643593,
-0.16889509558677673,
-0.0128104779869318,
-0.12893931567668915,
0.004090023227035999,
-0.10927903652191162,
0.02363210916519165,
-0.0021094942931085825,
0.09061166644096375,
-0.15584534406661987,
0.10387682914733887,
-0.05615909397602081,
-0.08126594126224518,
-0.12864066660404205,
-0.10040390491485596,
0.049997348338365555,
-0.06948837637901306,
-0.2262738049030304,
0.07372745871543884,
-0.0751219317317009,
-0.023589715361595154,
0.0006566792726516724,
0.015917714685201645,
0.015185697935521603,
0.1439286172389984,
-0.048737782984972,
0.04775804653763771,
-0.03251831233501434,
-0.08096536993980408,
0.11022157967090607,
0.08137879520654678,
0.06090184673666954,
-0.00013641569239553064,
-0.08019585907459259,
0.029292188584804535,
0.0633009821176529,
-0.12884356081485748,
0.08761142194271088,
0.026820791885256767,
-0.08458266407251358,
0.07295160740613937,
0.15415427088737488,
-0.0795522928237915,
0.11442394554615021,
0.02001115493476391,
0.09106463938951492,
-0.016615290194749832,
-0.21292705833911896,
0.10298934578895569,
0.05502275377511978,
0.0073677487671375275,
-0.2833021283149719,
0.02874218113720417,
-0.11885728687047958,
0.14102113246917725,
0.07653405517339706,
0.09427811205387115,
-0.18969523906707764,
0.029876410961151123,
0.09227520227432251,
-0.013809707947075367,
-0.19043710827827454,
0.2721906006336212,
-0.09463087469339371,
0.16874489188194275,
-0.0929885283112526,
-0.20977464318275452,
0.11410222947597504,
-0.24532605707645416,
0.1033991351723671,
-0.10767566412687302,
0.1346479207277298,
0.04692460969090462,
-0.06546223908662796,
-0.06456930190324783,
-0.016968602314591408,
-0.17973142862319946,
0.006486006546765566,
0.12100864946842194,
0.16770276427268982,
0.09269894659519196,
-0.02782367542386055,
0.08303628861904144,
-0.01005392987281084,
0.12554210424423218,
-0.0039508226327598095,
0.06577645242214203,
-0.16509583592414856,
0.04058369994163513,
-0.1464710533618927,
0.06944134086370468,
0.004074519500136375,
0.030400428920984268,
-0.23784418404102325,
-0.16445674002170563,
0.17691773176193237,
-0.04592552036046982,
-0.12712617218494415,
-0.0823761522769928,
0.09494348615407944,
0.1738746613264084,
0.09308170527219772,
-0.06952536106109619,
-0.018745578825473785,
0.057547252625226974,
0.07872483134269714,
0.09157146513462067,
0.04403744265437126,
0.016956856474280357,
-0.09269630163908005,
-0.029361916705965996,
-0.06743098795413971,
-0.28720706701278687,
0.07613074034452438,
0.005947081837803125,
-0.04800977557897568,
0.05805841088294983,
-0.22678130865097046,
0.00736323744058609,
-0.036018453538417816,
-0.09721697121858597,
0.21445755660533905,
0.14375033974647522,
-0.037552669644355774,
0.07481253147125244,
0.047465730458498,
0.12795665860176086,
0.0499894879758358,
0.3371717631816864,
0.1206621453166008,
0.04664211347699165,
0.07534867525100708,
0.11638755351305008,
-0.1137082502245903,
-0.01809467002749443,
0.027630813419818878,
-0.07026474177837372,
0.10068340599536896,
-0.033441174775362015,
-0.02745586819946766,
-0.09059090167284012,
-0.016674429178237915,
-0.09251946210861206,
-0.1066908910870552,
-0.14217059314250946,
-0.0029501612298190594,
-0.10616209357976913,
-0.12213589251041412,
0.23970355093479156,
-0.06059916317462921,
0.09325772523880005,
-0.027130169793963432,
0.08298519998788834,
-0.11706145107746124,
-0.025369465351104736,
0.02586756832897663,
-0.10644304752349854,
0.07422038167715073,
0.011267676949501038,
0.040812499821186066,
0.11823710054159164,
-0.12311052531003952,
0.036918528378009796,
-0.09282504767179489,
-0.07867162674665451,
0.09925122559070587,
0.00831183698028326,
0.07572954893112183,
0.18012267351150513,
-0.11015387624502182,
0.25394564867019653,
0.0647750273346901,
-0.010540131479501724,
-0.14140892028808594,
0.09216330945491791,
0.14021435379981995,
-0.07399103045463562,
0.030010830610990524,
-0.0632258877158165,
0.026569640263915062,
-0.31273141503334045,
0.09507186710834503,
0.048706747591495514,
0.03564697876572609,
0.0877167135477066,
0.044927213340997696,
0.0967792421579361,
-0.12211425602436066,
-0.1670200675725937,
0.09019871801137924,
0.036771178245544434,
-0.01080002449452877,
0.07695483416318893,
0.17063258588314056,
0.04803616926074028,
-0.10535462200641632,
0.06133848801255226,
0.10331029444932938,
-0.0652971938252449,
0.12990865111351013,
0.06802456825971603,
0.031069843098521233,
-0.06295310705900192,
-0.0010956355836242437,
-0.042811691761016846,
0.05890437588095665,
-0.03734767809510231,
-0.0005172397359274328,
0.023220261558890343,
-0.13965068757534027,
-0.07897917926311493,
-0.0788731500506401,
0.023132644593715668,
0.04229813814163208,
0.0890314057469368,
-0.07917604595422745,
-0.03219835087656975,
0.1405557245016098,
-0.03651417791843414,
-0.04889789968729019,
0.03253275156021118,
-0.08247864246368408,
-0.03458242863416672,
-0.04264979436993599,
-0.04301273822784424,
-0.09590031951665878,
0.13572357594966888,
0.0012255808105692267,
0.16827429831027985,
0.0843420997262001,
-0.09352738410234451,
0.03125839680433273,
-0.28809845447540283,
0.08971253037452698,
-0.049394357949495316,
0.11219234764575958,
-0.16251173615455627
] | [
-0.6405137181282043,
-0.40237531065940857,
-0.4379032552242279,
0.4858168959617615,
0.026843443512916565,
0.8250871896743774,
0.591051459312439,
0.49869590997695923,
-0.05352409556508064,
-0.5380819439888,
-0.030063176527619362,
0.1934276521205902,
-0.17665459215641022,
-0.2884982228279114,
0.21587994694709778,
0.6314683556556702,
0.07805005460977554,
0.01826055534183979,
0.7228599190711975,
-0.17166107892990112,
0.09680569171905518,
-0.02651747688651085,
0.3800112009048462,
0.005414656829088926,
-0.27775484323501587,
-0.3200223743915558,
-0.5080534815788269,
-0.2075829803943634,
-0.3583580255508423,
0.2830114960670471,
-0.5827750563621521,
0.12257585674524307,
0.436928391456604,
0.3532000184059143,
0.564717710018158,
0.048827674239873886,
-0.07594364136457443,
-0.12622830271720886,
0.053892455995082855,
0.07402795553207397,
-0.5602610111236572,
0.11546620726585388,
0.21992602944374084,
0.2670930027961731,
0.18983040750026703,
-0.04674329236149788,
-1.2200636863708496,
0.3175443112850189,
-0.17276346683502197,
-0.8183501362800598,
-0.5250676274299622,
-0.19748036563396454,
0.3238544166088104,
0.5963900089263916,
0.11509183794260025,
-0.107943594455719,
0.35183751583099365,
0.2924298644065857,
-0.15422554314136505,
0.19241882860660553,
0.8530176877975464,
0.5063220262527466,
0.34927883744239807,
0.2658578157424927,
-0.23652294278144836,
0.05941621586680412,
0.42366692423820496,
0.050829172134399414,
-0.19484123587608337,
-0.711532711982727,
0.17822271585464478,
0.7535077333450317,
0.14014923572540283,
0.10093405097723007,
-0.3228948712348938,
0.20055116713047028,
-0.19007807970046997,
0.28901323676109314,
0.10063039511442184,
-0.03848069906234741,
-0.1955675482749939,
-0.8078544735908508,
0.04586132615804672,
-0.11808034032583237,
-0.24477964639663696,
-0.40330132842063904,
0.8196008801460266,
-0.13639597594738007,
-0.9123497605323792,
0.4288228750228882,
-0.7800590991973877,
0.031614482402801514,
0.29552367329597473,
0.5088914632797241,
0.5439472794532776,
-0.18054720759391785,
-0.21971161663532257,
-0.05083504319190979,
0.6170822978019714,
-0.712860107421875,
-0.5503864288330078,
-0.9498862028121948,
-0.5838750004768372,
-0.03559653460979462,
-0.6456656455993652,
0.021811138838529587,
-1.0994744300842285,
0.11977823823690414,
-0.3225787580013275,
0.3308296799659729,
-0.7427442669868469,
-0.19227683544158936,
0.3549487292766571,
0.19111023843288422,
-0.39548635482788086,
-0.023019053041934967,
-0.0343155562877655,
-0.17994794249534607,
-0.1811835765838623,
-0.1845594048500061,
-0.005594165064394474,
0.1260816603899002,
-0.17074158787727356,
0.2197311520576477,
-0.20783691108226776,
0.035901594907045364,
-0.366798460483551,
0.30805057287216187,
-0.12659867107868195,
0.17417366802692413,
-0.03723131865262985,
-0.23911958932876587,
-0.2008027583360672,
0.026582183316349983,
-0.21551357209682465,
-0.5486097931861877,
-0.21325384080410004,
0.052347972989082336,
-0.03783343732357025,
0.07125475257635117,
-0.13377344608306885,
0.008458757773041725,
0.27349352836608887,
-0.34788942337036133,
0.39084601402282715,
-0.6821686029434204,
-0.6143672466278076,
0.24633195996284485,
-0.7538977265357971,
0.05913751944899559,
0.25489965081214905,
0.35555312037467957,
-0.1638355553150177,
0.3167976140975952,
0.3675808012485504,
0.3050578832626343,
0.007362578995525837,
-0.15388232469558716,
-0.3047502338886261,
-0.0821155235171318,
0.35859501361846924,
0.6810493469238281,
0.2259669452905655,
-0.08428235352039337,
0.7316536903381348,
-0.22368060052394867,
-0.6080368161201477,
0.48941099643707275,
-0.19647999107837677,
0.2771236002445221,
-0.5139791965484619,
-0.662840723991394,
0.27492234110832214,
-0.1847514808177948,
-0.250088095664978,
0.48996007442474365,
0.2121702879667282,
0.3231496810913086,
0.4580309987068176,
-0.3447554409503937,
-0.23925529420375824,
0.034911416471004486,
-0.20812639594078064,
0.06909839808940887,
0.10304594039916992,
-0.3709271252155304,
0.7266157865524292,
-0.01675555296242237,
0.24747776985168457,
-0.05028047785162926,
-0.44722867012023926,
0.11035291850566864,
0.42860254645347595,
0.007925187237560749,
0.03177899494767189,
-0.14207139611244202,
0.025058120489120483,
-0.006179651711136103,
-0.5869449973106384,
-0.5620450377464294,
-0.08105451613664627,
-0.01896088942885399,
0.08508529514074326,
-0.06164143607020378,
-0.6453149318695068,
0.2898566424846649,
-0.19194786250591278,
-0.8347829580307007,
-0.17305921018123627,
0.16413678228855133,
-0.01736634038388729,
0.29173094034194946,
-0.31920695304870605,
0.2484014332294464,
0.03193426504731178,
-0.05750153586268425,
-0.5523152947425842,
-0.37817129492759705,
-0.031182529404759407,
0.010498217307031155,
0.6141337156295776,
0.005562508013099432,
0.5754885673522949,
0.09742695093154907,
0.24905730783939362,
0.595888614654541,
0.3569446802139282,
-0.04178495332598686,
0.2616642415523529,
-0.33417198061943054,
-0.44338324666023254,
-0.18796509504318237,
-0.07724089920520782,
0.09030621498823166,
-0.18053226172924042,
-0.038269173353910446,
0.2791324555873871,
-0.3814674913883209,
0.440965473651886,
-0.4539218246936798,
-0.437311589717865,
0.27674201130867004,
-0.39244967699050903,
0.32035577297210693,
-0.34466156363487244,
0.2573222815990448,
0.030993448570370674,
0.2983739972114563,
-0.009839211590588093,
-0.38673514127731323,
0.11693607270717621,
-0.066309355199337,
-0.4121782183647156,
-0.1592489331960678,
0.7279937863349915,
-0.3668922781944275,
-0.6626343131065369,
-0.6304081082344055,
0.43349120020866394,
0.1777256727218628,
-0.11462395638227463,
0.4747953712940216,
0.04924236983060837,
-0.6568655371665955,
0.10712870955467224,
-0.2694474160671234,
-1.0508304834365845,
-1.1156034469604492,
0.39187684655189514,
-0.21080021560192108,
0.3013175129890442,
-0.02215932123363018,
-0.2811366319656372,
-0.37139707803726196,
-0.48152124881744385,
0.3146005868911743,
-0.023905877023935318,
0.2040567845106125,
-0.2825774848461151,
-0.6946139335632324,
0.10420634597539902,
0.7348901629447937,
-0.4308755397796631,
-0.3500937521457672,
-0.7078908085823059,
0.032581526786088943,
-0.06528077274560928,
-0.14389154314994812,
0.4443519115447998,
-0.3639358878135681,
-0.5161067247390747,
0.380062073469162,
0.3595781922340393,
0.2841747999191284,
-0.1788645088672638,
-0.1404784470796585,
-0.35559791326522827,
0.7628968358039856,
0.7743830680847168,
-0.26581716537475586,
0.2301884889602661,
0.248964324593544,
0.04240370914340019,
0.33601459860801697,
0.686220645904541,
-0.11663446575403214,
0.05191066861152649,
0.05023445561528206,
-5.926717758178711,
0.15985824167728424,
0.41227540373802185,
0.03696600720286369,
-0.06717564165592194,
-0.685660183429718,
-0.4523402154445648,
-0.00650072330608964,
0.6943573951721191,
-0.029640253633260727,
-0.2096613347530365,
-0.25302255153656006,
-0.2442178875207901,
0.3812408447265625,
0.215958833694458,
0.19777575135231018,
0.4026188850402832,
-0.5023983120918274,
0.30367109179496765,
0.43691158294677734,
0.02853456512093544,
0.1861387938261032,
-0.08519032597541809,
0.40896081924438477,
-0.1732265204191208,
0.446936696767807,
-0.3138706386089325,
0.4826297461986542,
-0.7074016332626343,
-0.14766176044940948,
-0.5846761465072632,
-0.09030564874410629,
-0.591183602809906,
-0.501499593257904,
-0.005868382286280394,
0.3856718838214874,
-0.028344735503196716,
-0.19734036922454834,
0.5262187719345093,
0.26671701669692993,
-0.3591674566268921,
0.4326573610305786,
-0.2670843005180359,
0.5088358521461487,
0.3468944728374481,
0.278751939535141,
0.9903849363327026,
0.050294771790504456,
-0.24699676036834717,
0.21231505274772644,
0.2671973407268524,
0.200454980134964,
0.8399147987365723,
-0.1555546373128891,
0.14770430326461792,
0.22617369890213013,
-0.34804847836494446,
-0.7687944769859314,
0.28784874081611633,
-0.1287899911403656,
-0.20163242518901825,
-0.1705934703350067,
0.31160253286361694,
0.3891797363758087,
-0.6762845516204834,
-0.03927423804998398,
-0.24367013573646545,
0.7660377025604248,
0.6083751916885376,
-0.11142442375421524,
0.4186219871044159,
0.13385175168514252,
-0.10049636662006378,
-0.7557066679000854,
-0.07680846005678177,
-0.09487045556306839,
-0.030416471883654594,
-0.056824762374162674,
-0.49155884981155396,
-0.19291633367538452,
-0.1154153123497963,
-0.0441974475979805,
0.0636155754327774,
0.12494843453168869,
0.5879583358764648,
-0.5662126541137695,
0.04872671514749527,
0.01690656691789627,
-0.14738738536834717,
0.15299998223781586,
-0.4060676395893097,
-1.2508771419525146,
0.4381316006183624,
-0.48191437125205994,
0.8022720813751221,
0.5865172743797302,
-0.029726622626185417,
0.0035025940742343664,
0.30741146206855774,
-0.19067350029945374,
0.10247617214918137,
0.15762104094028473,
-0.29479309916496277,
0.2469588965177536,
-0.14295031130313873,
0.6153372526168823,
-0.2612922787666321,
0.410405695438385,
0.3434380888938904,
-0.9637153744697571,
0.37005409598350525,
0.8671360015869141,
-0.07724590599536896,
0.5419739484786987,
-0.22870415449142456,
-0.195687398314476,
-0.13765989243984222,
-0.11901091784238815,
-0.3170420229434967,
-0.813113808631897,
-0.09001196175813675,
0.2522040605545044,
-0.1321377009153366,
-0.44381189346313477,
-0.1272321492433548,
0.337159663438797,
-0.034877993166446686,
-0.18754339218139648,
0.10602138191461563,
0.9518159627914429,
0.4172194004058838,
0.08056331425905228,
0.23670290410518646,
-0.26023632287979126,
0.598850429058075,
0.0900973454117775,
0.13066397607326508,
-0.677077054977417,
-0.3661991357803345,
0.04574254900217056,
0.3012562394142151,
0.02984621934592724,
-0.04079459235072136,
-0.1463468372821808,
0.3255300521850586,
-0.3803701400756836,
0.16178934276103973,
-0.2730391025543213,
-0.1169378012418747,
-0.32213449478149414,
-0.026793222874403,
-0.11395637691020966,
0.5738397836685181,
-0.14538982510566711,
-0.12061220407485962,
-0.4149736762046814,
-0.04234865680336952,
-0.3475729525089264,
-0.343759149312973,
-0.43574774265289307,
0.4395364224910736,
-0.5820834040641785,
-0.03472289443016052,
0.03676805645227432,
0.13348166644573212,
-0.3336793780326843,
-0.10264715552330017,
0.0874810665845871,
0.27708879113197327,
-0.2545282542705536,
-0.018138179555535316,
-0.6050015687942505,
0.09920167922973633,
0.16164147853851318,
0.14675846695899963,
0.012121990323066711,
-0.3198172152042389,
0.01902514323592186,
-0.26108139753341675,
0.07013783603906631,
-0.22209352254867554,
-0.2217928171157837,
-0.3744063675403595,
0.4201135039329529,
-0.04484299197793007,
0.3405519723892212,
-0.7450613975524902,
0.024716639891266823,
0.45330923795700073,
0.6937953233718872,
0.0752611756324768,
-0.832017183303833,
-0.045036546885967255,
0.5537779331207275,
-0.18164633214473724,
-0.35486695170402527,
0.25607869029045105,
-0.2295973151922226,
-0.02589963562786579,
-0.12025386095046997,
0.1403854638338089,
-0.2387540489435196,
-0.2451774626970291,
0.13782870769500732,
-0.5679054260253906,
-0.41225868463516235,
0.4581570625305176,
-0.20775218307971954,
-0.23662292957305908,
0.04961321875452995,
-0.18901465833187103,
-0.6870233416557312,
-0.5773178935050964,
0.18307825922966003,
-0.2945728302001953,
-0.38617920875549316,
-0.22496278584003448,
0.015849879011511803,
-0.268669992685318,
-0.2749374806880951,
0.03696984052658081,
-0.8148856163024902,
-0.38810479640960693,
-0.025172395631670952,
-0.1502196341753006,
0.04896705970168114,
0.22394172847270966,
-0.05397177115082741,
0.2469419240951538,
-0.03264225274324417,
-0.42337819933891296,
1.041951298713684,
-0.23077920079231262,
0.5565585494041443,
-0.31003889441490173,
0.608592689037323,
-0.7702485918998718,
0.08621510863304138,
-0.6096031665802002,
-0.02853826992213726,
0.29969823360443115,
0.2085707187652588,
-0.4000083804130554,
0.6077346205711365,
-0.518153965473175,
0.34654539823532104,
0.28409817814826965,
-0.6033403873443604,
-0.05450035631656647,
0.4529287815093994,
-0.6848151683807373,
0.0723842903971672,
0.20467908680438995,
-0.10367891937494278,
0.44089752435684204,
-0.36706554889678955,
0.18545079231262207,
-0.10165735334157944,
0.12503987550735474,
-0.046692509204149246,
-0.07009854167699814,
0.18909285962581635,
0.35962802171707153,
0.08282849192619324,
0.04460080713033676,
0.0568276047706604,
0.6421523094177246,
0.2641369700431824,
0.06410586833953857,
0.27596914768218994,
0.29972729086875916,
-0.7036498188972473,
-0.16414666175842285,
0.033663712441921234,
0.07351209223270416,
0.20434892177581787,
-0.46359142661094666,
-0.5439566373825073,
-0.9238333106040955,
0.7518335580825806,
-0.23520536720752716,
0.1129995658993721,
-0.23092907667160034,
0.11087613552808762,
-0.09935221821069717,
-0.9354085326194763,
0.16645683348178864,
0.17975454032421112,
-0.5378636717796326,
-0.5492104291915894,
0.41337937116622925,
0.5800880789756775,
0.10638631135225296,
-0.33817175030708313,
0.5746670961380005,
-0.022355975583195686,
-0.2026936411857605,
0.31927573680877686,
0.40780094265937805,
-0.05101113021373749,
-0.13658465445041656,
-0.8546320796012878,
-0.2016657441854477,
0.03351324796676636,
-0.1771748811006546,
-0.37395960092544556,
-0.03345078229904175,
-0.6526021361351013,
0.12836319208145142,
0.1983776092529297,
0.6344493627548218,
-0.4830472469329834,
0.00027233120636083186,
0.5377674102783203,
0.24042531847953796,
-0.018643002957105637,
0.20486709475517273,
-0.12828630208969116,
0.4258779287338257,
0.036379870027303696,
-0.12309711426496506,
0.968438446521759,
0.34873682260513306,
-0.10962457954883575,
-0.2355499267578125,
0.5139114856719971,
0.04202704504132271,
0.39189770817756653,
-0.1655423492193222,
0.05406373739242554,
0.7246348261833191,
0.09051239490509033,
0.22606003284454346,
0.4750409722328186,
-0.2502919137477875,
-0.41616392135620117,
0.3024485409259796,
-0.09973996132612228,
0.31970423460006714,
0.7033059597015381,
-0.14586137235164642,
-0.6549742221832275,
0.41837021708488464,
0.5309693217277527,
-0.09886568039655685,
0.3642052412033081,
0.17431573569774628,
0.18348105251789093,
-0.7551875710487366,
0.7793015241622925,
0.3865963816642761,
0.42172300815582275,
0.010295970365405083,
0.6963356733322144,
-0.21687792241573334,
-0.13037286698818207,
0.6820765137672424,
-0.027327176183462143,
-0.17987865209579468,
-0.07623502612113953,
0.5820028185844421,
0.35144758224487305,
0.09853458404541016,
-0.41020703315734863,
-1.1194757223129272,
0.6177181005477905,
0.2997124493122101,
-0.031544096767902374,
-0.06057187542319298,
-0.3863482177257538,
-0.5932437181472778,
-0.016541818156838417,
-0.17606118321418762,
0.8261231780052185,
0.457338809967041,
0.6508395075798035,
-0.0012006243923678994,
0.5394740104675293,
0.15253518521785736,
0.1912892609834671,
-0.43653446435928345,
0.17960892617702484,
-0.6596009135246277,
-0.2381877303123474,
0.01935752108693123,
-0.3261159658432007,
-0.1887521892786026,
0.29278498888015747,
0.3507181704044342,
0.19733290374279022,
-0.1805429607629776,
0.6191128492355347,
0.22348980605602264,
0.17281083762645721,
-0.2651877999305725,
-0.0181918703019619,
0.0824960470199585,
0.4466002881526947,
-0.030238976702094078,
0.28071486949920654,
0.23278141021728516,
0.2960681915283203,
0.18854571878910065,
0.32386285066604614,
-0.22935795783996582,
0.16373533010482788,
-0.31030547618865967,
0.3944079577922821,
-0.10205652564764023,
-0.27200567722320557,
0.2351718693971634,
0.1578563153743744,
-0.4197356700897217,
0.30079665780067444,
0.5369536876678467,
-0.018321508541703224,
-0.19461378455162048,
-0.057749275118112564,
0.5191723704338074,
-0.5366772413253784,
-0.2823029160499573,
-0.30010727047920227,
0.48116350173950195,
0.5730797052383423,
0.4100930392742157,
0.7864708304405212,
-0.25818997621536255,
0.06303063780069351,
-0.14138896763324738,
0.10440759360790253,
-0.022119775414466858,
-0.05415227636694908,
-0.4690716862678528,
-0.0709342360496521,
-0.22036102414131165,
-0.42220842838287354,
0.48474106192588806,
-0.46471768617630005,
0.4343828856945038,
-0.17350706458091736,
-0.04658008739352226,
0.04700089618563652,
0.530000627040863,
-0.028570136055350304,
0.434516042470932,
-0.6207054853439331,
0.6326807737350464,
0.35986989736557007,
-0.19263778626918793,
0.8151133060455322,
-0.0821625366806984,
-0.09531925618648529,
0.04366768151521683,
-0.11371362954378128,
0.5795555710792542,
-0.13917334377765656,
-0.04046087712049484,
-0.2095411717891693,
0.17678895592689514,
0.14281535148620605
] |
|
The innate immune response is essential for controlling West Nile virus (WNV) infection but how this response is propagated and regulates adaptive immunity in vivo are not defined. Herein, we show that IPS-1, the central adaptor protein to RIG-I-like receptor (RLR) signaling, is essential for triggering of innate immunity and for effective development and regulation of adaptive immunity against pathogenic WNV. IPS-1(−/−) mice exhibited increased susceptibility to WNV infection marked by enhanced viral replication and dissemination with early viral entry into the CNS. Infection of cultured bone-marrow (BM) derived dendritic cells (DCs), macrophages (Macs), and primary cortical neurons showed that the IPS-1-dependent RLR signaling was essential for triggering IFN defenses and controlling virus replication in these key target cells of infection. Intriguingly, infected IPS-1(−/−) mice displayed uncontrolled inflammation that included elevated systemic type I IFN, proinflammatory cytokine and chemokine responses, increased numbers of inflammatory DCs, enhanced humoral responses marked by complete loss of virus neutralization activity, and increased numbers of virus-specific CD8+ T cells and non-specific immune cell proliferation in the periphery and in the CNS. This uncontrolled inflammatory response was associated with a lack of regulatory T cell expansion that normally occurs during acute WNV infection. Thus, the enhanced inflammatory response in the absence of IPS-1 was coupled with a failure to protect against WNV infection. Our data define an innate/adaptive immune interface mediated through IPS-1-dependent RLR signaling that regulates the quantity, quality, and balance of the immune response to WNV infection. | [
0.0019241857808083296,
-0.0022342666052281857,
-0.02882673405110836,
0.016550445929169655,
-0.03239655867218971,
0.023504551500082016,
0.01037946529686451,
0.009619351476430893,
-0.00932358205318451,
0.014568460173904896,
-0.007921408861875534,
0.00901319831609726,
-0.02084754779934883,
0.00852152518928051,
0.028649266809225082,
0.018498878926038742,
-0.006494028493762016,
0.02849951758980751,
0.005069127306342125,
-0.013721265830099583,
0.003376203589141369,
0.011860040947794914,
0.011323697865009308,
-0.01249128021299839,
0.029143644496798515,
-0.00210341764613986,
0.010189389809966087,
-0.010784373618662357,
-0.025767751038074493,
-0.0042558470740914345,
-0.007263618521392345,
-0.0003549655666574836,
0.027841664850711823,
-0.008250413462519646,
-0.007077278569340706,
0.0030272086150944233,
-0.01566038466989994,
0.01936730369925499,
0.015455884858965874,
-0.004249895922839642,
-0.009202579967677593,
-0.010043987073004246,
0.012104138731956482,
0.0034739626571536064,
-0.005968709010630846,
-0.024561971426010132,
-0.002970305969938636,
0.0006159436888992786,
-0.022864002734422684,
0.01045692153275013,
-0.005660682916641235,
-0.0001586945727467537,
-0.025103438645601273,
0.0030815796926617622,
-0.007093882188200951,
0.009312817826867104,
0.01783440262079239,
0.019603054970502853,
-0.012960381805896759,
0.009507283568382263,
0.017000548541545868,
-0.001054304651916027,
0.010609122924506664,
-0.005091706290841103,
-0.01400891412049532,
-0.06663263589143753,
0.024267124012112617,
0.009244145825505257,
0.012167583219707012,
0.005010195076465607,
-0.004811250604689121,
0.006138920783996582,
-0.03106127493083477,
-0.011568982154130936,
-0.05135408788919449,
-0.015642253682017326,
-0.020177852362394333,
0.012257838621735573,
0.004113480448722839,
0.03240593522787094,
-0.007705249357968569,
-0.0016841890756040812,
0.01543143019080162,
0.011489059776067734,
0.0038830654229968786,
0.014814143069088459,
-0.030717359855771065,
-0.002459562849253416,
-0.04822155833244324,
0.0011318393517285585,
-0.013925187289714813,
-0.009774170815944672,
-0.02134699560701847,
0.00842200219631195,
0.0036682956852018833,
-0.016126073896884918,
0.0007703015580773354,
0.004395963158458471,
0.03647220507264137,
0.008590063080191612,
-0.010163424536585808,
0.01590498723089695,
0.01721416413784027,
-0.0023400012869387865,
0.01394618209451437,
0.0089784637093544,
0.04700671136379242,
0.014413608238101006,
0.01529636699706316,
0.010369990020990372,
-0.003924952819943428,
0.001116504892706871,
0.003801415441557765,
0.04564395546913147,
-0.008702192455530167,
-0.003400960471481085,
-0.011400748044252396,
0.007943170145154,
0.01471103448420763,
0.014503955841064453,
-0.02783537283539772,
0.011903809383511543,
0.00248902034945786,
0.02095893770456314,
0.0010796100832521915,
0.02433348447084427,
0.002086498774588108,
0.021229557693004608,
-0.0059426650404930115,
0.006186128593981266,
-0.009206400252878666,
0.012207482010126114,
0.005797801539301872,
-0.03069891594350338,
0.009125685319304466,
0.00831165537238121,
0.01217314600944519,
-0.0011533817742019892,
0.003030370455235243,
-0.01479822676628828,
-0.02791224978864193,
0.01208469271659851,
0.0003497657016851008,
0.02367367222905159,
0.000298358965665102,
0.013110683299601078,
0.03526053577661514,
0.005175331607460976,
0.009277328848838806,
0.008927939459681511,
0.00033677415922284126,
-0.0029754838906228542,
0.013935101218521595,
-0.022026175633072853,
0.011010348796844482,
0.01978026144206524,
-0.03386908769607544,
-0.01991141587495804,
-0.010969397611916065,
-0.007789005525410175,
0.030282162129878998,
0.007447797805070877,
0.033309150487184525,
0.009567752480506897,
0.013561371713876724,
0.006159891840070486,
-0.004759104922413826,
-0.02127750962972641,
-0.005789926275610924,
0.004603786394000053,
-0.01017552800476551,
0.017956556752324104,
0.0019325390458106995,
0.006726066116243601,
0.01829337328672409,
-0.008273476734757423,
0.027694623917341232,
0.004617276135832071,
-0.005086468532681465,
0.06630993634462357,
0.025872644037008286,
-0.005145798437297344,
-0.003133019432425499,
0.009269382804632187,
-0.0014898637309670448,
-0.014685234986245632,
0.03323209285736084,
-0.004834807477891445,
-0.01844988577067852,
-0.004437421448528767,
-0.025297008454799652,
-0.011501621454954147,
0.0009240712970495224,
0.004256023094058037,
-0.022083664312958717,
0.0026877946220338345,
0.04158193618059158,
0.01217175554484129,
-0.0038630811031907797,
0.01985139027237892,
0.002906319685280323,
-0.016390059143304825,
0.04201728105545044,
-0.013202814385294914,
-0.029116416350007057,
0.015387052670121193,
-0.01869218982756138,
0.018010994419455528,
-0.014314182102680206,
-0.009635090827941895,
0.04430633783340454,
-0.027399249374866486,
-0.005962568335235119,
-0.011086211539804935,
0.004940413869917393,
-0.0036219367757439613,
0.0014327657409012318,
-0.02704104594886303,
0.009022139012813568,
-0.011406522244215012,
-0.002062467159703374,
0.013471899554133415,
-0.02078273333609104,
-0.01927170902490616,
0.05302968621253967,
0.02330985851585865,
-0.0039188312366604805,
0.010082419961690903,
-0.026667218655347824,
0.00696002971380949,
-0.0003330986946821213,
-0.015385886654257774,
-0.015684492886066437,
-0.03009110689163208,
0.02624693512916565,
0.009952087886631489,
0.014236945658922195,
-0.0015807469608262181,
0.016010258346796036,
-0.01485840417444706,
-0.022685125470161438,
-0.010588955134153366,
0.024891871958971024,
0.0092165507376194,
0.01783227175474167,
-0.010373210534453392,
-0.007520351093262434,
0.00661671906709671,
0.000710155931301415,
-0.029196273535490036,
0.009673764929175377,
0.016917962580919266,
-0.009285922162234783,
-0.041153471916913986,
-0.018903285264968872,
-0.02097487449645996,
-0.00275810738094151,
-0.013285650871694088,
0.025059737265110016,
0.016303380951285362,
0.005465863272547722,
0.006363504566252232,
-0.026928775012493134,
-0.013142463751137257,
-0.011157585307955742,
0.023933859542012215,
0.00273165013641119,
0.005007992032915354,
-0.015876084566116333,
0.022630739957094193,
0.009481173940002918,
-0.009378188289701939,
-0.00851491279900074,
-0.08126730471849442,
-0.015300659462809563,
0.008059957064688206,
-0.007588290609419346,
0.011699243448674679,
-0.04226037114858627,
0.006464381702244282,
0.010770557448267937,
-0.016040770336985588,
0.023490384221076965,
-0.009358333423733711,
0.022744785994291306,
-0.008495992980897427,
-0.025988543406128883,
0.0076415217481553555,
-0.002591270487755537,
0.013646634295582771,
0.0029475814662873745,
-0.029488839209079742,
-0.01895895227789879,
-0.00952486414462328,
0.010857455432415009,
0.021459858864545822,
-0.007397782988846302,
0.012129604816436768,
-0.01139844674617052,
0.003330229315906763,
-0.004477871581912041,
-0.010034531354904175,
-0.0036804252304136753,
-0.012849069200456142,
-0.026161402463912964,
0.010526943951845169,
0.009404515847563744,
0.05130111798644066,
0.021571166813373566,
-0.008165723644196987,
-0.04420648515224457,
-0.0014824788086116314,
0.017302192747592926,
0.002919113263487816,
0.011622272431850433,
0.008328765630722046,
0.010433195158839226,
0.00431591272354126,
-0.010537270456552505,
-0.015492405742406845,
0.015042372979223728,
0.00767797976732254,
-0.0024687591940164566,
0.026682423427700996,
0.001735886326059699,
-0.010437515564262867,
0.02063344605267048,
-0.005342425778508186,
-0.010086233727633953,
-0.03101368248462677,
0.01136469841003418,
-0.009267829358577728,
-0.0058321827091276646,
0.009739505127072334,
0.0523524135351181,
0.020319566130638123,
0.020403465256094933,
-0.021067647263407707,
0.008829452097415924,
0.01740318350493908,
0.019904281944036484,
-0.025399675592780113,
0.013321819715201855,
-0.013029675930738449,
0.006623590365052223,
-0.008323678746819496,
-0.0057238563895225525,
-0.00037089036777615547,
-0.009133584797382355,
-0.017427727580070496,
-0.015451288782060146,
-0.002331359311938286,
-0.012054070830345154,
-0.028678834438323975,
0.007800687104463577,
-0.012055041268467903,
-0.003353568259626627,
-0.01681140623986721,
-0.009480233304202557,
0.00679452158510685,
0.03362419083714485,
0.016968613490462303,
-0.018019065260887146,
0.03913646936416626,
0.03620452433824539,
-0.000769040547311306,
0.009306386113166809,
-0.030920688062906265,
-0.0001151813194155693,
-0.021022530272603035,
0.007304759696125984,
0.0027675935998559,
0.009585961699485779,
-0.036247506737709045,
-0.015137191861867905,
-0.022771747782826424,
-0.004632182884961367,
-0.010365307331085205,
0.013941200450062752,
0.007305130362510681,
0.010208659805357456,
0.0007488875999115407,
-0.0028481455519795418,
0.011849304661154747,
-0.0184539295732975,
-0.0054649789817631245,
0.009814811870455742,
0.008276025764644146,
0.02693793922662735,
-0.0022235303185880184,
-0.01493368111550808,
0.07209325581789017,
-0.004927054978907108,
0.0026056370697915554,
-0.014201968908309937,
0.01577092707157135,
-0.013266917318105698,
-0.011106494814157486,
0.003482645843178034,
-0.015892712399363518,
0.02592385746538639,
0.012655969709157944,
-0.0408526286482811,
-0.05509074032306671,
0.013197658583521843,
-0.003223864361643791,
0.010619929991662502,
-0.010758543387055397,
-0.00897508580237627,
0.02052266150712967,
0.0504809245467186,
0.020975442603230476,
-0.014239046722650528,
-0.00013057934120297432,
-0.009764006361365318,
0.012359564192593098,
-0.008719956502318382,
0.019677167758345604,
-0.011347307823598385,
-0.015581108629703522,
0.007784808985888958,
-0.016034992411732674,
-0.02838144078850746,
-0.010586999356746674,
-0.01751624047756195,
-0.007695274893194437,
-0.011362195946276188,
0.014481870457530022,
-0.03236113116145134,
-0.009448760189116001,
-0.011422992683947086,
-0.004330349154770374,
-0.01784672960639,
-0.0013533090241253376,
0.009058425202965736,
-0.021401964128017426,
0.012395350262522697,
-0.027430597692728043,
-0.0049167051911354065,
-0.0027137715369462967,
0.004577922634780407,
-0.007862739264965057,
0.013851523399353027,
0.009826685301959515,
0.007208387367427349,
-0.02835410088300705,
0.010285640135407448,
0.018655169755220413,
-0.012138991616666317,
-0.014929383061826229,
-0.03521137684583664,
0.0034902191255241632,
-0.024795331060886383,
-0.0029135001823306084,
-0.020826511085033417,
0.015408247709274292,
-0.022486135363578796,
0.007049933075904846,
0.008931167423725128,
0.018406441435217857,
-0.027415774762630463,
0.009412781335413456,
0.026958992704749107,
-0.023938985541462898,
0.003840810852125287,
-0.015288849361240864,
0.025007177144289017,
-0.025963371619582176,
0.010910224169492722,
0.023967644199728966,
0.011038180440664291,
-0.02864205092191696,
0.009675150737166405,
0.008283417671918869,
-0.011102146469056606,
0.014627685770392418,
0.004494726657867432,
-0.03593863174319267,
-0.0748358741402626,
-0.007624369114637375,
-0.0037830390501767397,
-0.005469169933348894,
0.01282294001430273,
0.030764970928430557,
-0.014013268053531647,
0.018243977800011635,
-0.033966146409511566,
-0.01621050015091896,
0.025759834796190262,
-0.0020077386870980263,
0.029375089332461357,
-0.014272579923272133,
0.010769428685307503,
0.014623142778873444,
-0.031090516597032547,
0.009756556712090969,
-0.006391027942299843,
-0.01630202680826187,
0.01727338507771492,
-0.011417857371270657,
-0.04373374581336975,
0.004981523379683495,
-0.0010776492999866605,
-0.08089974522590637,
0.00983949564397335,
0.01688309758901596,
-0.015334300696849823,
0.005826868116855621,
-0.011446080170571804,
0.0407162606716156,
-0.010768374428153038,
-0.020270274952054024,
-0.015750840306282043,
0.00859349686652422,
0.0015333080664277077,
-0.018092453479766846,
0.0007163910195231438,
0.028471052646636963,
-0.014191821217536926,
0.025437505915760994,
-0.018624581396579742,
0.04154214262962341,
-0.01015064399689436,
-0.005504919216036797,
-0.0057324254885315895,
-0.012672334909439087,
-0.009033754467964172,
-0.007809930946677923,
-0.03495865315198898,
-0.007919508963823318,
0.014008814468979836,
-0.007242972031235695,
-0.01781381480395794,
0.0019344876054674387,
0.005300162360072136,
-0.027634456753730774,
-0.01971565932035446,
0.00017750076949596405,
-0.005868680775165558,
0.008206665515899658,
0.012065516784787178,
0.02755029872059822,
0.0012957412982359529,
-0.009523160755634308,
0.007524766959249973,
-0.0031187713611871004,
0.025540264323353767,
-0.026781093329191208,
-0.011955015361309052,
0.007819180376827717,
-0.001530924579128623,
0.01961655169725418,
-0.013074596412479877,
-0.000010541873052716255,
-0.018319236114621162,
0.01747676357626915,
0.0062483856454491615,
0.049275197088718414,
0.027857139706611633,
-0.008457643911242485,
-0.0053505371324718,
-0.00875844806432724,
0.0005363321397453547,
-0.0032183213625103235,
0.011839782819151878,
-0.0028026201762259007,
0.07132279872894287,
-0.019316937774419785,
0.014027440920472145,
-0.01963980868458748,
0.012667926028370857,
0.00476041529327631,
-0.003347171936184168,
0.009850263595581055,
-0.02004772238433361,
-0.048210617154836655,
-0.010658321902155876,
-0.015136460773646832,
0.008142821490764618,
0.015247493982315063,
0.03243916481733322,
0.01595585234463215,
-0.010628958232700825,
-0.005399811547249556,
0.0062864795327186584,
0.02187405899167061,
-0.0010770633816719055,
0.0007144249975681305,
-0.030067384243011475,
-0.010592328384518623,
0.051307082176208496,
-0.01116563193500042,
0.015918811783194542,
0.008175077848136425,
-0.016619879752397537,
0.018371501937508583,
0.004716176073998213,
0.0022492134012281895,
0.00041198357939720154,
-0.040228940546512604,
0.01925094984471798,
-0.004356634337455034,
0.006031765602529049,
0.011809613555669785,
-0.015126893296837807,
0.0200650691986084,
0.03222076967358589,
0.019584260880947113,
0.004026791080832481,
-0.0011306358501315117,
0.04494592174887657,
0.009935561567544937,
0.036189787089824677,
-0.009092694148421288,
0.020242754369974136,
-0.003173910081386566,
-0.0025585321709513664,
-0.0035812505520880222,
0.005829662550240755,
0.006317733321338892,
0.005096732173115015,
0.01243286021053791,
0.011769350618124008,
0.0165153406560421,
-0.010667323134839535,
0.0001796374563127756,
0.012236175127327442,
-0.01885511353611946,
0.0124265868216753,
-0.013057217001914978,
0.013464735820889473,
-0.026896104216575623,
-0.0006326232105493546,
-0.010781187564134598,
-0.04189246520400047,
0.011574090458452702,
-0.04625794291496277,
0.005279351957142353,
0.01262543722987175,
0.019916687160730362,
0.05476822704076767,
0.010899018496274948,
0.0249620508402586,
0.0013885876396670938,
0.02086535096168518,
-0.014595074579119682,
-0.008297782391309738,
-0.01862199418246746,
-0.0049463901668787,
0.006522112060338259,
0.004384447354823351,
0.021966367959976196,
0.0014305396471172571,
-0.023073362186551094,
0.00023360183695331216,
0.012413584627211094,
-0.01148927491158247,
0.019613929092884064,
0.00950765423476696,
-0.010321157053112984,
0.0037999851629137993,
0.03442537784576416,
0.03341217711567879,
0.007891345769166946,
-0.006293610669672489,
0.001474226824939251,
0.013370373286306858,
-0.008970415219664574,
-0.0072173066437244415,
0.023522045463323593,
0.000752732390537858,
-0.0018754693446680903,
0.014807493425905704,
0.017739200964570045,
0.0011080289259552956,
-0.022062884643673897,
-0.003696306375786662,
-0.008907648734748363,
0.01328402291983366,
0.00483689084649086,
-0.002923925407230854,
0.020974641665816307,
-0.014633970335125923,
-0.017592130228877068,
-0.0068939197808504105,
-0.010319402441382408,
0.006803073454648256,
0.02430889382958412,
0.008389929309487343,
0.0044668009504675865,
-0.023243756964802742,
-0.030044523999094963,
-0.015690555796027184,
-0.0015968915540724993,
0.002890294650569558,
-0.03385545313358307,
0.016428954899311066,
-0.026950299739837646,
-0.006606639362871647,
-0.001205777283757925,
-0.006962234620004892,
0.0031927116215229034,
0.027802255004644394,
-0.007135690655559301,
0.01054280437529087,
-0.0013742826413363218,
-0.012499954551458359,
-0.022495830431580544,
0.003071095561608672,
-0.019778408110141754,
0.007154872640967369,
-0.024905867874622345,
0.014030234888195992,
0.01163328904658556,
0.008267713710665703,
0.0076718805357813835,
0.02322886511683464,
-0.0038757678121328354,
-0.01061577070504427,
-0.005270854104310274,
0.017370926216244698,
0.023792479187250137,
-0.0009918785654008389,
0.0051108598709106445,
-0.018128089606761932,
-0.003307678736746311,
0.016077619045972824,
-0.008154070936143398,
-0.007363410200923681,
0.016639702022075653,
0.0026550372131168842,
-0.01926303468644619,
0.044676825404167175,
0.02249947562813759,
-0.009181646630167961,
-0.004160664975643158,
0.02440427988767624,
-0.014856377616524696,
0.006672502029687166,
0.002128364285454154,
-0.025491084903478622,
-0.008910609409213066,
0.0015939059667289257,
0.006106871645897627,
-0.00853629969060421,
0.01678706333041191,
0.004081326071172953,
-0.04693122208118439,
-0.0157130416482687,
-0.01282529253512621,
0.016984526067972183,
0.0029629019554704428,
-0.005824625957757235,
0.023768728598952293,
-0.0025003678165376186,
0.005183213856071234,
-0.0069214762188494205,
-0.0052302442491054535,
-0.005228384863585234,
0.006387044675648212,
0.0029316996224224567,
-0.008177700452506542,
-0.026346435770392418,
-0.024728544056415558,
0.004357857629656792,
-0.008953639306128025,
0.0002879723906517029,
-0.005742307286709547
] | [
-0.14301089942455292,
-0.005439887288957834,
-0.1664033830165863,
-0.12406119704246521,
-0.22637754678726196,
0.08751230686903,
0.4391232132911682,
-0.41891005635261536,
-0.21932584047317505,
-0.5260917544364929,
0.36712369322776794,
0.42575255036354065,
-0.25750237703323364,
0.12076467275619507,
-0.03067958727478981,
0.5778701305389404,
0.33366480469703674,
0.19944144785404205,
-0.35390251874923706,
-0.24710950255393982,
0.010645303875207901,
-0.27076947689056396,
0.04757630079984665,
0.1559676080942154,
0.23501145839691162,
-0.12244314700365067,
0.5271681547164917,
-0.14819368720054626,
0.5557619333267212,
-0.5109112858772278,
-0.020458394661545753,
0.3294188678264618,
-0.17482300102710724,
-0.367203027009964,
-0.5068532824516296,
-0.07808154076337814,
-0.5704206824302673,
0.1356499046087265,
0.19993720948696136,
-0.14374257624149323,
-0.24683798849582672,
-0.26802241802215576,
-0.25148072838783264,
0.4209960997104645,
-0.16604915261268616,
-0.39727917313575745,
-1.193701982498169,
0.7165749669075012,
-0.027718229219317436,
0.14266103506088257,
-0.2996378242969513,
-0.003970935940742493,
0.25681260228157043,
-0.13711701333522797,
0.34490153193473816,
0.17129942774772644,
-0.6204540729522705,
-0.11593411862850189,
0.27186763286590576,
-0.47781574726104736,
0.035095538944005966,
-0.0018994269194081426,
-0.22807084023952484,
0.12958385050296783,
-0.26006293296813965,
1.0388343334197998,
-0.1004127487540245,
-0.05910864472389221,
-0.14269356429576874,
0.16167902946472168,
0.10561227798461914,
-0.3081631362438202,
0.01407389622181654,
0.3046548366546631,
0.013132068328559399,
-0.43381166458129883,
-0.22743451595306396,
-0.6689263582229614,
-0.04934486001729965,
0.4277307987213135,
-0.10721611976623535,
-0.31976422667503357,
0.2693876028060913,
-0.48479196429252625,
0.6133534908294678,
0.2575368583202362,
0.3692696988582611,
0.31105518341064453,
-0.6896354556083679,
-0.17267270386219025,
-0.06676174700260162,
0.07934892922639847,
0.31413841247558594,
0.17998717725276947,
-0.07709942758083344,
0.3832477629184723,
-0.02425657957792282,
-0.09179718047380447,
0.07435501366853714,
0.09154435247182846,
-0.34523212909698486,
-0.18459640443325043,
-0.225337952375412,
-0.4037005603313446,
-0.791325569152832,
-0.07096730917692184,
-0.3043025732040405,
-0.8544463515281677,
-0.6103554368019104,
0.2375960648059845,
-0.5810456275939941,
0.058232586830854416,
-0.2190455198287964,
-0.5747418403625488,
-0.1395139992237091,
0.27493715286254883,
0.1974986493587494,
-0.48187026381492615,
0.17896051704883575,
0.33682742714881897,
-0.23617589473724365,
1.4541903734207153,
-0.12157882750034332,
0.8211554884910583,
-0.2951224744319916,
-0.2520143687725067,
0.26700425148010254,
0.019019903615117073,
0.12032847106456757,
0.4240487217903137,
0.1558220386505127,
0.8572481274604797,
-0.28290310502052307,
0.20978698134422302,
-0.05967898294329643,
0.29179954528808594,
0.11183178424835205,
0.3652903437614441,
-0.20035001635551453,
-0.19109046459197998,
-0.7068813443183899,
-0.5916905403137207,
-0.027390772476792336,
-0.1005711778998375,
-0.3239574432373047,
-0.49735739827156067,
-0.2632119059562683,
0.21838922798633575,
0.2094351053237915,
-0.08644022792577744,
0.05277416110038757,
-0.36980465054512024,
-0.6819047927856445,
-0.1233019009232521,
-0.2692168056964874,
0.5894243717193604,
-0.1354348063468933,
-0.04308173805475235,
0.155556321144104,
0.32991236448287964,
0.3098679780960083,
-0.32861849665641785,
-0.17430034279823303,
-0.19574348628520966,
0.39214539527893066,
0.09609971940517426,
0.5164365172386169,
0.42649006843566895,
-0.10974130779504776,
-0.44545242190361023,
-0.4751732647418976,
-0.4934151768684387,
0.06996021419763565,
-0.41029608249664307,
-0.1238768994808197,
-0.32263368368148804,
0.32266855239868164,
0.03964900225400925,
0.24725553393363953,
0.1581430435180664,
-0.6550225019454956,
-0.2820671498775482,
-0.5378996729850769,
-0.48619329929351807,
0.8395025134086609,
0.25144726037979126,
0.10476633906364441,
0.16086676716804504,
0.026196779683232307,
0.319637268781662,
-0.07788914442062378,
-0.15239198505878448,
0.5597769618034363,
-0.5729668736457825,
1.3489844799041748,
-0.29080909490585327,
-0.09104626625776291,
1.5788078308105469,
0.3111143410205841,
-0.002781730843707919,
0.30177515745162964,
-0.15075810253620148,
0.6577197313308716,
-0.23015594482421875,
-0.2874288856983185,
0.15281325578689575,
-0.18735869228839874,
-0.08259188383817673,
0.16850650310516357,
0.08358334749937057,
0.196383997797966,
0.22627303004264832,
-0.21061834692955017,
-0.3618376553058624,
0.36198845505714417,
-0.10204794257879257,
-0.01854308694601059,
-0.044215623289346695,
-0.2724246680736542,
-0.03910576179623604,
0.5480318665504456,
-0.5813172459602356,
0.6165622472763062,
1.1501177549362183,
-0.17025282979011536,
0.5655452013015747,
0.5179551243782043,
0.23365077376365662,
1.0403891801834106,
-0.19549821317195892,
0.30287525057792664,
-0.5536301136016846,
0.4241413474082947,
-0.4767152965068817,
-0.22938475012779236,
0.2527078688144684,
0.2853797674179077,
0.008560797199606895,
0.30449435114860535,
0.08711428195238113,
0.14118075370788574,
0.9514668583869934,
-0.7421021461486816,
0.0951361432671547,
0.1417531967163086,
-0.28178876638412476,
-0.11186520010232925,
0.2306521087884903,
-1.0557705163955688,
-0.2876109778881073,
0.3015661835670471,
0.35858190059661865,
0.6277082562446594,
-0.5254670977592468,
0.2841803729534149,
-0.10452339053153992,
-0.2880699038505554,
-0.11286106705665588,
0.38228973746299744,
-0.29461681842803955,
0.2483932077884674,
0.03422195464372635,
0.2262997329235077,
0.24373529851436615,
0.23797526955604553,
-0.3598468601703644,
-0.8649175763130188,
-0.37404486536979675,
0.7984669804573059,
0.7592812776565552,
0.987758994102478,
0.09010067582130432,
-0.227687805891037,
-0.009701721370220184,
0.498995840549469,
-0.4544558525085449,
0.06286913901567459,
0.9189925193786621,
-0.2636108696460724,
-0.2850992977619171,
-0.11362607032060623,
0.05617982894182205,
0.7060231566429138,
-0.25189951062202454,
-0.28035756945610046,
-0.05755597725510597,
-0.4460260272026062,
-0.454331636428833,
-0.6397888660430908,
-0.13182172179222107,
-0.10700218379497528,
0.33766624331474304,
-0.004307510796934366,
0.21555092930793762,
0.37879547476768494,
0.34568893909454346,
-0.26754239201545715,
0.4313601851463318,
0.5972725749015808,
-0.1126585602760315,
-0.12218939512968063,
0.4993491470813751,
-0.47902533411979675,
-0.07849960774183273,
-0.3974881172180176,
0.042613089084625244,
-0.43738043308258057,
0.20123253762722015,
-5.857684135437012,
0.06575726717710495,
-0.09642376005649567,
-0.20537525415420532,
-0.12366297096014023,
-0.17224682867527008,
0.9225349426269531,
0.2679484188556671,
0.38376563787460327,
0.5535988211631775,
0.6249253749847412,
0.5054572224617004,
-0.05199587345123291,
-0.12437287718057632,
-0.46998438239097595,
0.06802616268396378,
-0.05031723529100418,
-0.15936103463172913,
0.3791876435279846,
-0.03482556715607643,
0.17821969091892242,
-0.049399323761463165,
-0.2534469962120056,
0.25430479645729065,
0.05799790471792221,
-0.1669309437274933,
-1.033243179321289,
0.07808113098144531,
-0.02046942338347435,
-0.19309359788894653,
0.2133684903383255,
-0.5083954930305481,
-0.029391197487711906,
-0.1419277787208557,
0.24795058369636536,
0.11197789013385773,
-0.14508725702762604,
-0.12580710649490356,
0.10320701450109482,
-0.3060043156147003,
0.10910449177026749,
-0.1327943354845047,
-0.24375581741333008,
-0.19610804319381714,
-0.004070098511874676,
-0.14999234676361084,
0.04653412848711014,
0.144961878657341,
-0.0841914564371109,
0.5148882865905762,
-0.591916024684906,
-0.3078015446662903,
0.22156068682670593,
0.8048228621482849,
0.43463605642318726,
-0.12243868410587311,
-0.22506117820739746,
0.09346312284469604,
-0.4544931650161743,
0.21749579906463623,
-0.6867810487747192,
-0.368426650762558,
-0.21737250685691833,
-0.653201699256897,
0.4292460083961487,
0.18797409534454346,
-0.4832877218723297,
-0.7642618417739868,
0.4793627858161926,
-0.14819258451461792,
0.015832874923944473,
-0.04667467623949051,
0.2319512665271759,
-0.7320444583892822,
0.6035504937171936,
-0.6957573890686035,
0.09954030811786652,
0.1997767686843872,
-0.12204363942146301,
-0.537171483039856,
-0.1635580062866211,
-0.4218254089355469,
-0.21756906807422638,
-0.004106766078621149,
-0.032442137598991394,
-0.16380222141742706,
0.05941043049097061,
-0.3928663432598114,
-0.11319322139024734,
0.3389277458190918,
0.7140181064605713,
-0.3482981324195862,
-0.08757790923118591,
0.4870835244655609,
-0.3633599579334259,
0.27917176485061646,
0.32745787501335144,
0.8403524160385132,
0.5706896781921387,
-0.04897153750061989,
0.8347128629684448,
-0.3280026614665985,
-0.4436798691749573,
-0.7297355532646179,
-0.41339728236198425,
0.6003598570823669,
-0.4504121243953705,
-0.024817222729325294,
1.3872748613357544,
-0.7272868156433105,
-0.1407039761543274,
-0.10505685955286026,
-0.4381411671638489,
0.005580763332545757,
0.5454309582710266,
-0.24853304028511047,
-0.08251714706420898,
0.18828412890434265,
0.9021707773208618,
-0.17678271234035492,
0.5991252660751343,
0.5546740293502808,
-0.6305148601531982,
0.311311811208725,
0.26536068320274353,
0.05241071432828903,
0.25522878766059875,
0.540795087814331,
-0.9481688141822815,
-0.43022865056991577,
0.22370706498622894,
0.19707249104976654,
-0.7673091292381287,
0.2753938138484955,
0.35708972811698914,
-0.2735847532749176,
-0.3161252737045288,
0.2206885665655136,
0.23028604686260223,
-0.14781160652637482,
-0.04403049498796463,
-0.3315775692462921,
0.011515215039253235,
-0.01492965966463089,
-0.21186180412769318,
0.04811795800924301,
-0.02533622831106186,
-0.05336979031562805,
-0.8179025650024414,
-0.27259108424186707,
0.40959632396698,
-0.2621237337589264,
0.057678576558828354,
0.32911816239356995,
-0.5715683102607727,
0.4709967076778412,
0.3788512945175171,
0.3738393783569336,
0.39370566606521606,
-0.5674758553504944,
0.4676065444946289,
0.37001022696495056,
-0.48373961448669434,
-0.014192277565598488,
0.08663869649171829,
-0.2892402112483978,
-0.0803726464509964,
-0.3439585268497467,
-0.0975048691034317,
0.24159830808639526,
-0.211664080619812,
-0.11471238732337952,
-0.19815486669540405,
-0.38211286067962646,
0.18885082006454468,
-0.19471757113933563,
-0.37667274475097656,
0.4228112995624542,
-0.0328075997531414,
0.281271368265152,
0.29294145107269287,
-0.379487007856369,
-0.2580125033855438,
0.3792473375797272,
0.4814192056655884,
-0.054658882319927216,
0.03099469467997551,
-0.31492680311203003,
-0.17771443724632263,
-0.2609023451805115,
0.42740190029144287,
0.1025969386100769,
0.5581523180007935,
-0.44199705123901367,
0.06049901992082596,
0.04203737899661064,
0.11232217401266098,
0.2414863258600235,
-0.18213267624378204,
-0.778626561164856,
0.11832504719495773,
0.4649617373943329,
-0.4082164466381073,
0.5571120381355286,
0.14715656638145447,
0.13681960105895996,
-0.21733082830905914,
0.009478370659053326,
-0.06764598935842514,
-0.27507737278938293,
0.019567737355828285,
-0.7213599681854248,
0.39833661913871765,
0.3783920109272003,
-0.08437733352184296,
-0.12279023975133896,
0.031134149059653282,
-0.4094480872154236,
-0.06276442110538483,
0.5518108010292053,
-0.1047636941075325,
-0.05828825756907463,
0.0890253409743309,
-0.0797954574227333,
-0.2940120995044708,
0.009745043702423573,
0.14846500754356384,
-0.8244697451591492,
0.2930869162082672,
0.19679230451583862,
-0.027179503813385963,
-0.23818489909172058,
0.23149608075618744,
0.20227286219596863,
-0.39338216185569763,
-0.3305203914642334,
-0.26527243852615356,
0.23608170449733734,
-0.014756938442587852,
0.5508582592010498,
0.23023004829883575,
0.3372553586959839,
-0.29289740324020386,
0.010245237499475479,
0.012009833008050919,
0.367399126291275,
0.07675565779209137,
-0.4011141359806061,
-0.3487110137939453,
-0.011576579883694649,
0.21282915771007538,
-0.042875852435827255,
-0.10647186636924744,
0.43452009558677673,
1.105078101158142,
-0.07841529697179794,
0.3139742910861969,
-0.28338858485221863,
-0.2484196275472641,
-0.038046710193157196,
-0.09246321022510529,
0.35433512926101685,
-0.23884911835193634,
0.03551356494426727,
-0.14094288647174835,
-0.11127625405788422,
-0.29099151492118835,
-0.790298581123352,
0.24595239758491516,
0.008166822604835033,
-0.15287750959396362,
-0.24728548526763916,
0.767682671546936,
0.3662419021129608,
-0.032070551067590714,
0.31131717562675476,
-0.4126313626766205,
0.4138895869255066,
-0.05831311643123627,
0.05397671088576317,
0.00528976833447814,
-0.7086649537086487,
0.29158860445022583,
-0.4265902638435364,
0.4864503741264343,
-0.5311680436134338,
-0.14776676893234253,
-0.709815502166748,
0.13550089299678802,
-0.4280034899711609,
-0.683829665184021,
0.07316224277019501,
-0.6321654915809631,
-0.368442177772522,
0.09624376893043518,
0.22465401887893677,
0.08019616454839706,
0.38843604922294617,
-0.03010113537311554,
0.03591093420982361,
-0.6275768280029297,
0.8046042919158936,
0.42727071046829224,
0.3628506362438202,
-0.29556769132614136,
0.5041354298591614,
0.5095070004463196,
0.45528632402420044,
-0.6025745868682861,
-0.3365653455257416,
-0.2320297658443451,
-0.4186042547225952,
0.5818694829940796,
-0.18994273245334625,
-0.6160382628440857,
0.16910520195960999,
0.1985427290201187,
-0.2765558660030365,
0.06274224817752838,
0.14260555803775787,
0.4166402518749237,
0.2103036642074585,
0.4320882260799408,
-0.020519398152828217,
-0.21933424472808838,
1.0254579782485962,
-0.14296777546405792,
-0.1924423724412918,
0.1922629326581955,
0.6247867345809937,
0.45182377099990845,
0.12834028899669647,
-0.30653688311576843,
0.3580169379711151,
0.4055650532245636,
0.4917866587638855,
0.44540995359420776,
-0.17284196615219116,
-0.31917765736579895,
0.2900981307029724,
0.572426974773407,
0.4922373592853546,
-0.36448103189468384,
-0.417961984872818,
0.10618587583303452,
0.2334233522415161,
0.06755217909812927,
0.37276822328567505,
-0.04564350098371506,
0.1660085916519165,
0.21980245411396027,
-0.5596498250961304,
-0.1874312460422516,
0.3653807044029236,
-0.756015419960022,
0.3124486207962036,
0.5297176241874695,
-0.44307148456573486,
-0.3940126299858093,
0.4595896303653717,
-0.07090011984109879,
-0.4171684980392456,
0.6125251650810242,
0.549472451210022,
-0.04333323985338211,
-0.05048951506614685,
0.3354523777961731,
0.23302212357521057,
0.28588801622390747,
0.04803872108459473,
-0.2096516340970993,
-0.38765913248062134,
-0.16606198251247406,
0.056393228471279144,
0.3724570572376251,
-0.2933269441127777,
-0.08430194854736328,
-0.2608122229576111,
-0.21562933921813965,
0.6226212978363037,
-0.3128959536552429,
0.20020295679569244,
-0.45684346556663513,
-0.9263755083084106,
-0.3693554103374481,
-0.27375349402427673,
-0.4673985540866852,
-0.21925009787082672,
-0.46764636039733887,
0.10542050749063492,
-0.1333208680152893,
-0.6858188509941101,
-0.059038981795310974,
0.2213600128889084,
0.14675740897655487,
-0.0032572345808148384,
-0.11146871745586395,
0.289956271648407,
0.1804351806640625,
0.5983559489250183,
-0.11088697612285614,
0.6308332085609436,
-0.3721289336681366,
0.3552544116973877,
-0.5384573340415955,
0.46480774879455566,
-0.7055155038833618,
-0.017796268686652184,
-0.3801281154155731,
-0.55031418800354,
0.7980175018310547,
0.685433030128479,
-0.21555553376674652,
-0.042318567633628845,
0.08124194294214249,
0.1722262054681778,
0.5024169087409973,
-0.706864058971405,
-0.1841679960489273,
-0.5733060240745544,
-0.5803612470626831,
-0.8512864708900452,
0.5294190645217896,
0.09740697592496872,
-0.32952913641929626,
-0.22707068920135498,
0.8548381328582764,
0.39006125926971436,
-0.37507954239845276,
0.38865578174591064,
-0.1922791749238968,
-0.10137508064508438,
-0.7444519400596619,
0.1833617389202118,
-0.6598409414291382,
-0.11268122494220734,
-0.17387937009334564,
0.3096671402454376,
0.3126291036605835,
0.24941186606884003,
0.4778980314731598,
-0.2768515646457672,
0.345002144575119,
0.26939040422439575,
-0.05328952521085739,
0.08877604454755783,
-0.2130323052406311,
-0.6557075381278992,
-0.4229651093482971,
0.38770607113838196,
0.04772317782044411,
-0.46514302492141724,
0.0014800261706113815,
0.09155489504337311,
0.04049801453948021,
0.056589752435684204,
0.22107848525047302,
-0.40054020285606384,
-0.20644666254520416,
0.11005264520645142
] |
BACKGROUND: Zoonotic malaria caused by Plasmodium knowlesi is an important, but newly recognized, human pathogen. For the first time, post-mortem findings from a fatal case of knowlesi malaria are reported here. CASE PRESENTATION: A formerly healthy 40 year-old male became symptomatic 10 days after spending time in the jungle of North Borneo. Four days later, he presented to hospital in a state of collapse and died within two hours. He was hyponatraemic and had elevated blood urea, potassium, lactate dehydrogenase and amino transferase values; he was also thrombocytopenic and eosinophilic. Dengue haemorrhagic shock was suspected and a post-mortem examination performed. Investigations for dengue virus were negative. Blood for malaria parasites indicated hyperparasitaemia and single species P. knowlesi infection was confirmed by nested-PCR. Macroscopic pathology of the brain and endocardium showed multiple petechial haemorrhages, the liver and spleen were enlarged and lungs had features consistent with ARDS. Microscopic pathology showed sequestration of pigmented parasitized red blood cells in the vessels of the cerebrum, cerebellum, heart and kidney without evidence of chronic inflammatory reaction in the brain or any other organ examined. Brain sections were negative for intracellular adhesion molecule-1. The spleen and liver had abundant pigment containing macrophages and parasitized red blood cells. The kidney had evidence of acute tubular necrosis and endothelial cells in heart sections were prominent. CONCLUSIONS: The overall picture in this case was one of systemic malaria infection that fit the WHO classification for severe malaria. Post-mortem findings in this case were unexpectedly similar to those that define fatal falciparum malaria, including cerebral pathology. There were important differences including the absence of coma despite petechial haemorrhages and parasite sequestration in the brain. These results suggest that further study of knowlesi malaria will aid the interpretation of, often conflicting, information on malaria pathophysiology in humans. | [
-0.0030625215731561184,
0.00698316004127264,
-0.007787337061017752,
0.011477900668978691,
0.0037956794258207083,
-0.01320572104305029,
0.009332863613963127,
0.01120966300368309,
-0.014692222699522972,
-0.016666673123836517,
-0.0030690105631947517,
0.005683861672878265,
-0.007179157342761755,
0.01590089686214924,
0.024568304419517517,
-0.020779332146048546,
-0.015797508880496025,
0.019182994961738586,
0.01743348315358162,
-0.002126239240169525,
-0.004831599537283182,
0.016057496890425682,
0.010465694591403008,
0.0041814204305410385,
0.016742102801799774,
0.0010527991689741611,
0.0008664652705192566,
-0.02477765455842018,
-0.025074634701013565,
0.02999311313033104,
0.0011949259787797928,
0.022336365655064583,
-0.004379353020340204,
-0.005892629735171795,
0.01663011871278286,
0.010162226855754852,
-0.004655763506889343,
0.017401324585080147,
0.01577705517411232,
-0.004150340799242258,
0.011196752078831196,
-0.008637506514787674,
0.0043259961530566216,
-0.010236699134111404,
-0.00929191429167986,
-0.03606395423412323,
-0.0003356167580932379,
0.009586622938513756,
-0.0027969328220933676,
0.0008345908718183637,
-0.011245847679674625,
0.008030133321881294,
-0.013914182782173157,
-0.006780428811907768,
-0.006148917600512505,
0.018082626163959503,
0.0176217183470726,
0.018822183832526207,
0.00292225438170135,
-0.017023451626300812,
-0.021923083811998367,
-0.025599466636776924,
-0.0125670675188303,
-0.0036118612624704838,
-0.03547438606619835,
-0.06728073954582214,
0.014064735732972622,
0.016715051606297493,
-0.0144968805834651,
0.017346534878015518,
-0.01542692817747593,
0.001992535777390003,
-0.00709646986797452,
-0.013641773723065853,
0.011930324137210846,
-0.00016044406220316887,
-0.026192408055067062,
-0.005018865689635277,
-0.015492383390665054,
0.004640267230570316,
0.02079465426504612,
0.010847065597772598,
0.003012270200997591,
0.008387367241084576,
-0.027905955910682678,
0.02759774588048458,
-0.017816070467233658,
0.0029248909559100866,
-0.009249219670891762,
-0.0023689535446465015,
-0.007503177504986525,
0.026181546971201897,
-0.0009736161446198821,
0.0043595400638878345,
-0.009766044095158577,
-0.01911356672644615,
-0.025302432477474213,
0.023611780256032944,
0.017042063176631927,
-0.006507118698209524,
-0.00626650033518672,
-0.008625960908830166,
0.01551872119307518,
0.012460852041840553,
0.011242171749472618,
0.00205732649192214,
-0.027323808521032333,
-0.011748324148356915,
0.00589380320161581,
0.011664868332445621,
-0.02293708175420761,
0.014985095709562302,
-0.0010573272593319416,
0.015133712440729141,
0.0066977995447814465,
-0.003994170576334,
0.023451561108231544,
-0.0036346048582345247,
0.0009411385981366038,
0.0018314095214009285,
0.007405666634440422,
0.0013721424620598555,
-0.008740391582250595,
0.009526588954031467,
-0.0017137725371867418,
-0.016974516212940216,
0.018573589622974396,
-0.011528060771524906,
0.032250843942165375,
-0.015386030077934265,
-0.006208404898643494,
-0.004109151661396027,
-0.01973375678062439,
0.006965995766222477,
0.0035185529850423336,
0.0036425068974494934,
-0.037540681660175323,
0.007490621879696846,
-0.007095264736562967,
-0.010266449302434921,
-0.012938439846038818,
0.011067070998251438,
0.0007662519928999245,
0.020457427948713303,
0.008431154303252697,
0.002787210512906313,
-0.02900821901857853,
0.021132539957761765,
-0.005969769787043333,
0.0181901752948761,
0.009012358263134956,
-0.00257304054684937,
0.008689518086612225,
-0.0007338834693655372,
-0.009568787179887295,
0.007155848201364279,
-0.02103445678949356,
-0.015446104109287262,
-0.01264927163720131,
0.019393498077988625,
0.018668800592422485,
0.016528427600860596,
-0.012029238045215607,
0.00970574002712965,
-0.007967650890350342,
-0.03392878174781799,
0.012510616332292557,
-0.004505516961216927,
-0.004098741337656975,
0.005221952684223652,
0.00045145669719204307,
0.007544881198555231,
0.018077310174703598,
0.008326211012899876,
-0.02112957090139389,
-0.003919511567801237,
0.03978218883275986,
0.007774437312036753,
0.0005349387647584081,
0.06710007786750793,
-0.028253382071852684,
-0.007689855992794037,
0.03750506043434143,
-0.006234345957636833,
0.04561099037528038,
-0.005102596711367369,
0.01635665073990822,
-0.001612199004739523,
-0.0002931118942797184,
0.007335517089813948,
0.011207610368728638,
-0.016910061240196228,
-0.010120270773768425,
0.022107956930994987,
-0.02384704351425171,
0.0016723335720598698,
-0.011603441089391708,
0.0024387454614043236,
0.0031200009398162365,
0.02726975455880165,
0.009631429798901081,
0.012062746100127697,
0.022122718393802643,
-0.039759330451488495,
0.0220598466694355,
0.015124611556529999,
-0.0010489730630069971,
0.011600187048316002,
-0.02072196826338768,
-0.009740561246871948,
0.014188695698976517,
-0.0006117415614426136,
-0.01616133376955986,
-0.01516368892043829,
0.012457580305635929,
-0.0014985534362494946,
0.01068906020373106,
0.030694879591464996,
-0.010774738155305386,
-0.008659756742417812,
-0.00501618068665266,
0.009005436673760414,
-0.016638824716210365,
0.013231437653303146,
0.0054253749549388885,
-0.029169220477342606,
0.00499926321208477,
0.007928119041025639,
0.01902557536959648,
0.017935048788785934,
-0.02183634415268898,
-0.019620083272457123,
-0.010898839682340622,
-0.003689534030854702,
-0.0011374838650226593,
0.011754250153899193,
0.01530084665864706,
-0.010347222909331322,
0.015120267868041992,
-0.014129356481134892,
0.0005999808199703693,
-0.014335527084767818,
-0.009065802209079266,
0.011273803189396858,
0.047429658472537994,
-0.029343023896217346,
0.03078610450029373,
0.019622210413217545,
-0.0015967052895575762,
0.0031178456265479326,
0.01396935060620308,
0.0006873952224850655,
-0.019493963569402695,
0.022321373224258423,
-0.004558810032904148,
-0.00757792592048645,
-0.003885166486725211,
0.0030839184764772654,
0.022896263748407364,
-0.01415271870791912,
0.014876281842589378,
0.002974651288241148,
-0.011451568454504013,
-0.005318019073456526,
0.013660982251167297,
0.0066761355847120285,
0.027707217261195183,
0.013479458168148994,
-0.015135091729462147,
0.002575892023742199,
0.008404592052102089,
-0.0039053228683769703,
-0.003251604503020644,
-0.0816107764840126,
-0.002941881073638797,
-0.012997282668948174,
-0.016141410917043686,
-0.0036870217882096767,
0.027641555294394493,
0.008125714026391506,
-0.007881207391619682,
-0.009766103699803352,
-0.009932823479175568,
0.005904592573642731,
0.005027906037867069,
0.005747686140239239,
-0.0047089774161577225,
0.02105545625090599,
0.00006038647552486509,
0.006524263881146908,
-0.010594022460281849,
-0.014081276953220367,
-0.0140445027500391,
0.0068702357821166515,
0.007337004877626896,
0.011890360154211521,
-0.02244594320654869,
-0.0024663545191287994,
-0.022801674902439117,
0.007338872179389,
0.006645840592682362,
0.017360486090183258,
0.010142741724848747,
-0.0076341028325259686,
-0.014942847192287445,
0.0017847204580903053,
-0.009675325825810432,
0.002878461964428425,
0.009602122940123081,
-0.0057845767587423325,
0.007889212109148502,
-0.013806752860546112,
0.025709934532642365,
-0.00933721475303173,
0.011842613108456135,
0.011017431505024433,
-0.014981215819716454,
0.01133565790951252,
0.01856817677617073,
0.019284628331661224,
0.02206612378358841,
0.011298664845526218,
-0.017665863037109375,
-0.02016962692141533,
-0.001141221378929913,
0.005141815636307001,
0.010478058829903603,
-0.010503651574254036,
-0.005435356870293617,
0.0036397185176610947,
-0.024196956306695938,
-0.0013585929991677403,
-0.006056631915271282,
-0.017739709466695786,
-0.0036695459857583046,
0.029821190983057022,
-0.005941485520452261,
-0.025312235578894615,
0.03185608237981796,
0.01636316627264023,
-0.0034918771125376225,
-0.016418471932411194,
0.00012138718739151955,
-0.0023742513731122017,
0.006937590893357992,
-0.03295253589749336,
-0.01716831512749195,
-0.01011262834072113,
0.006506156176328659,
-0.01567423902451992,
-0.002928287722170353,
-0.010519884526729584,
0.002013177378103137,
0.004303155466914177,
0.008062469772994518,
-0.0034116138704121113,
0.011314846575260162,
-0.012398060411214828,
-0.018333230167627335,
0.017463944852352142,
0.02015707455575466,
0.007544474210590124,
-0.0104988943785429,
0.01721247285604477,
0.0227607823908329,
-0.01368352584540844,
0.015345406718552113,
-0.0005892044864594936,
-0.005443369969725609,
-0.010477248579263687,
-0.028068583458662033,
0.00224456749856472,
0.006213581655174494,
0.02291209250688553,
-0.02295798808336258,
-0.018636304885149002,
-0.008749092929065228,
-0.008220641873776913,
0.010299173183739185,
0.023893173784017563,
-0.008999829180538654,
-0.021752728149294853,
-0.003050557803362608,
-0.00018505658954381943,
0.016835739836096764,
-0.0023832302540540695,
0.008300382643938065,
0.009891527704894543,
0.007668495178222656,
-0.001249946653842926,
-0.010333648882806301,
0.07252009212970734,
0.010330038145184517,
0.015145589597523212,
-0.02814031019806862,
0.014975300058722496,
-0.024931147694587708,
0.000639717560261488,
0.005132684018462896,
-0.02533065155148506,
-0.0028987869154661894,
0.011554613709449768,
-0.01700524426996708,
-0.024851925671100616,
-0.0217793807387352,
-0.01566564105451107,
-0.009992202743887901,
-0.008960230275988579,
-0.010740329511463642,
-0.004366107285022736,
0.03355066478252411,
0.02010449767112732,
-0.00995485670864582,
-0.019008222967386246,
0.01972227171063423,
0.016628190875053406,
0.00411465996876359,
-0.0012697242200374603,
-0.013060507364571095,
-0.0253989826887846,
0.006579425185918808,
-0.012232108972966671,
0.025378186255693436,
-0.010445158928632736,
-0.01585993729531765,
-0.032225824892520905,
0.008036792278289795,
-0.00959104299545288,
0.005978228524327278,
0.017611145973205566,
-0.019633382558822632,
-0.00872420147061348,
-0.00904102809727192,
0.005732226185500622,
0.0022804562468081713,
0.001061887014657259,
-0.0030231724958866835,
0.019350897520780563,
-0.008416853845119476,
-0.005536276381462812,
0.012231511995196342,
-0.0008796323672868311,
0.022391196340322495,
0.00489514647051692,
0.00591198168694973,
-0.037897173315286636,
-0.019823670387268066,
-0.007720296271145344,
-0.006505854893475771,
-0.014930584467947483,
-0.0018891585059463978,
-0.011320539750158787,
-0.001281163189560175,
0.03981763869524002,
-0.014250010251998901,
0.01039671991020441,
-0.008832044899463654,
0.003480141283944249,
0.01944456808269024,
-0.013840273953974247,
0.006221695803105831,
0.005996814463287592,
0.009928797371685505,
0.004620802588760853,
0.0030144345946609974,
-0.021437082439661026,
0.013031459413468838,
-0.011847942136228085,
0.030016828328371048,
-0.009033655747771263,
-0.006086152978241444,
-0.012833407148718834,
-0.00047583633568137884,
0.00920327752828598,
-0.01363804005086422,
-0.00029838550835847855,
-0.0018597564194351435,
-0.021674372255802155,
-0.07458090782165527,
-0.0010797415161505342,
0.006462821736931801,
-0.0060838814824819565,
0.008916661143302917,
-0.026942282915115356,
-0.033679645508527756,
0.029215775430202484,
-0.029432930052280426,
-0.009680243209004402,
-0.0009975070133805275,
-0.004621974192559719,
-0.0013521467335522175,
0.000823581125587225,
0.015158949419856071,
0.025342551991343498,
0.010325675830245018,
-0.0010811829706653953,
-0.016100920736789703,
-0.026555778458714485,
0.022784944623708725,
0.01682993210852146,
-0.0039050839841365814,
0.022118914872407913,
0.010311777703464031,
-0.08128573000431061,
-0.024381253868341446,
0.0002038637176156044,
-0.0024280298966914415,
-0.015030446462333202,
0.014118731953203678,
0.010973969474434853,
-0.01585882157087326,
-0.010624443180859089,
-0.014162412844598293,
0.008175129070878029,
-0.01594281569123268,
0.0017615808174014091,
-0.017579223960638046,
0.006654419004917145,
-0.009125269949436188,
0.01718827523291111,
-0.030214790254831314,
0.012299241498112679,
0.02206467092037201,
-0.009178606793284416,
0.0007072077132761478,
-0.005493576638400555,
-0.007852812297642231,
-0.005177390296012163,
-0.014543219469487667,
0.004443129990249872,
0.01766597107052803,
0.007022322621196508,
-0.0017434980254620314,
0.024524345993995667,
-0.02039741352200508,
-0.008762707002460957,
0.0078100599348545074,
0.0019040587358176708,
0.0054466500878334045,
0.009556506760418415,
0.01513274572789669,
0.0007487986003980041,
-0.017583273351192474,
-0.0037272400222718716,
0.009662915952503681,
0.012636750005185604,
0.017277993261814117,
-0.0328226238489151,
0.017098216339945793,
0.00811127107590437,
-0.013329870067536831,
0.00733498390763998,
0.01440715603530407,
0.0068108332343399525,
-0.005723496899008751,
0.002954136347398162,
0.010516404174268246,
-0.0016476225573569536,
-0.006105901673436165,
0.0016688454197719693,
-0.0015127509832382202,
-0.00765359029173851,
0.012708161026239395,
0.005302933044731617,
0.011804117821156979,
-0.011166790500283241,
0.07214149832725525,
-0.002448142971843481,
-0.018244266510009766,
-0.03356776386499405,
-0.008204000070691109,
0.007104261312633753,
0.0017776396125555038,
0.025627989321947098,
-0.020615603774785995,
-0.016020502895116806,
-0.002114408416673541,
-0.0021812375634908676,
-0.005162111949175596,
0.010780265554785728,
0.040088947862386703,
-0.0015238183550536633,
0.027511637657880783,
0.0035027130506932735,
-0.012675552628934383,
0.005450990051031113,
-0.007314256392419338,
-0.005506855435669422,
-0.029850902035832405,
-0.007570008747279644,
0.00428504403680563,
-0.0054865251295268536,
0.014522315934300423,
0.0037883897311985493,
-0.004813480190932751,
0.0042693642899394035,
-0.011852024123072624,
0.015255765989422798,
0.003742358647286892,
0.014871140941977501,
0.005907424725592136,
0.02435891516506672,
0.008178084157407284,
0.01215716078877449,
-0.0026766760274767876,
0.010965187102556229,
0.022822976112365723,
-0.009960006922483444,
0.014196604490280151,
0.001455939607694745,
-0.0075668636709451675,
-0.0050470707938075066,
0.014019351452589035,
0.015587414614856243,
0.013384444639086723,
0.00191585929132998,
-0.020125867798924446,
0.02090669609606266,
0.01735670678317547,
-0.0009301563259214163,
-0.015287184156477451,
-0.012601194903254509,
-0.014076454564929008,
0.017316697165369987,
-0.0056860363110899925,
-0.009142225608229637,
0.012314964085817337,
-0.005952262319624424,
-0.028124168515205383,
-0.01940833404660225,
0.006994329858571291,
0.011478396132588387,
0.01849973574280739,
0.00038501800736412406,
-0.01746925711631775,
0.007692660205066204,
-0.01072201319038868,
0.024117115885019302,
0.006348799914121628,
-0.006866008043289185,
0.008949169889092445,
0.009803676046431065,
0.0031246007420122623,
-0.0031973666045814753,
-0.005382143892347813,
0.009625058621168137,
-0.01465151272714138,
-0.010588963516056538,
0.017651613801717758,
-0.023946093395352364,
-0.009092679247260094,
0.012806888669729233,
0.012667919509112835,
0.010757183656096458,
-0.004270249977707863,
0.0012083090841770172,
-0.019170096144080162,
0.017146099358797073,
0.0005575278773903847,
0.0004396275617182255,
0.008814716711640358,
0.03363417834043503,
0.007362667471170425,
0.0052193403244018555,
0.02087550424039364,
0.009606009349226952,
-0.03350728750228882,
-0.006666830740869045,
-0.007605103775858879,
-0.011677185073494911,
0.0034331544302403927,
0.0007715437095612288,
0.008579665794968605,
0.0032741462346166372,
0.00968044064939022,
0.008609093725681305,
-0.00563325360417366,
0.0035730614326894283,
0.011453410610556602,
-0.005097010638564825,
0.01968998834490776,
0.007329882588237524,
-0.015478990040719509,
0.008310303092002869,
0.030705008655786514,
-0.013324213214218616,
-0.027086753398180008,
-0.02213180810213089,
-0.013128473423421383,
0.021440962329506874,
-0.017588704824447632,
-0.0013804171467199922,
-0.0037284574937075377,
-0.0015109116211533546,
-0.006546116434037685,
-0.024355042725801468,
0.022763308137655258,
-0.044165849685668945,
-0.013125835917890072,
-0.02084708958864212,
-0.047694846987724304,
0.024196462705731392,
-0.005937223322689533,
0.005552058108150959,
-0.022847682237625122,
-0.025615539401769638,
0.01081782951951027,
-0.008115451782941818,
0.006053003016859293,
-0.009587853215634823,
0.00806600134819746,
-0.02224540337920189,
-0.009915657341480255,
0.0026701739989221096,
0.017223607748746872,
-0.024002499878406525,
-0.010949171148240566,
0.03317364305257797,
-0.022783678025007248,
-0.003853579517453909,
-0.004520789720118046,
-0.00608809944242239,
0.03128981590270996,
-0.004670713096857071,
0.025935323908925056,
0.026084739714860916,
-0.013481760397553444,
-0.00443615484982729,
0.02700338140130043,
-0.005761986598372459,
-0.01071571372449398,
0.004598372615873814,
-0.012387281283736229,
-0.012759855017066002,
0.022075017914175987,
-0.005321524105966091,
0.018505645915865898,
0.008049344643950462,
-0.02138807252049446,
-0.004621496424078941,
-0.030372178182005882,
-0.00878081563860178,
-0.0024848051834851503,
-0.012428240850567818,
-0.001077096676453948,
0.014192178845405579,
-0.0013795113191008568,
0.009395473636686802,
0.0013340616133064032,
-0.010844741016626358,
-0.001792642055079341,
0.003038974478840828,
-0.004949003458023071,
0.005393315572291613,
-0.005455140024423599,
-0.018502678722143173,
-0.002048914786428213,
-0.028549162670969963,
0.013141917064785957,
0.009502500295639038,
-0.01137623656541109,
-0.016655277460813522,
0.009789852425456047,
0.006387603469192982,
0.012312982231378555,
0.009153611958026886,
0.03084048442542553,
-0.012390006333589554
] | [
0.1552286297082901,
0.16855807602405548,
-0.15429961681365967,
0.10322093218564987,
0.24097880721092224,
0.3714157044887543,
0.6776604652404785,
0.01209836546331644,
-0.3564823567867279,
-0.3532739579677582,
0.03969275951385498,
-0.26178789138793945,
-0.2570223808288574,
0.3424378037452698,
-0.009172755293548107,
0.9725795984268188,
0.41658490896224976,
0.25581276416778564,
-0.4492911994457245,
-0.2715834677219391,
-0.3130149841308594,
-0.8534353971481323,
0.05412978306412697,
0.1963462382555008,
0.21606148779392242,
-0.07902196794748306,
-0.07174430787563324,
0.023441484197974205,
-0.2170722633600235,
0.022287676110863686,
-0.021131528541445732,
0.2771620750427246,
0.6480871438980103,
-0.40375816822052,
-0.25503113865852356,
0.07178231328725815,
-0.44678083062171936,
-0.05182472988963127,
0.2911357581615448,
-0.23124051094055176,
-0.05989884212613106,
-0.02368084341287613,
-0.03464163839817047,
0.5872453451156616,
0.20475739240646362,
-0.42832237482070923,
-1.083956003189087,
0.2896936237812042,
-0.7970581650733948,
-0.17763814330101013,
0.5035380125045776,
0.08055348694324493,
0.4827236235141754,
-0.06584584712982178,
0.023484786972403526,
-0.12372469156980515,
-0.4895881712436676,
0.152587428689003,
0.16638946533203125,
-0.6401083469390869,
0.4525582790374756,
0.03864644095301628,
-0.017883582040667534,
0.26580479741096497,
-0.4160107374191284,
0.30885589122772217,
0.34991157054901123,
0.27693912386894226,
0.08171310275793076,
0.08792269229888916,
0.35547301173210144,
0.17108197510242462,
-0.017900338396430016,
0.27933764457702637,
-0.13594719767570496,
-0.21041809022426605,
-0.24947227537631989,
-0.65633225440979,
0.5087531208992004,
0.05245913565158844,
-0.01711875945329666,
-0.07466968148946762,
0.3866725564002991,
-0.26154905557632446,
0.3264729380607605,
0.11150252819061279,
0.24075603485107422,
0.40591514110565186,
0.05138397961854935,
0.19330725073814392,
-0.3033008575439453,
0.1117183268070221,
0.049286406487226486,
0.6838732957839966,
-0.41100382804870605,
0.08489560335874557,
-0.21684737503528595,
-0.04679730534553528,
0.2284497171640396,
-0.22580724954605103,
-0.04950287938117981,
-0.5362305641174316,
-0.13547195494174957,
0.10051054507493973,
0.10541145503520966,
-0.0931624323129654,
-0.326992005109787,
-0.06825186312198639,
-0.7662943601608276,
0.2823578119277954,
-0.6502458453178406,
-0.0008107250323519111,
-0.29222267866134644,
-0.5071951150894165,
-0.2187989056110382,
0.3066103756427765,
0.19241024553775787,
-0.6185992360115051,
-0.03468253090977669,
-0.1793028712272644,
-0.7475175857543945,
0.3439294099807739,
-0.3480246365070343,
0.3503403663635254,
0.22144900262355804,
-0.13351233303546906,
-0.15486197173595428,
-0.05644340068101883,
0.05349590629339218,
1.0404419898986816,
0.39453181624412537,
0.3179865777492523,
0.045359812676906586,
0.12615391612052917,
-0.2859978973865509,
-0.2958674728870392,
-0.1516624540090561,
0.6461200714111328,
-0.1553722769021988,
0.061446111649274826,
-0.4001629054546356,
-0.058964092284440994,
-0.5128364562988281,
0.678521990776062,
0.23934759199619293,
0.042219582945108414,
-0.06910280883312225,
0.3140430450439453,
-0.23429349064826965,
-0.18480749428272247,
0.19759374856948853,
-0.42237672209739685,
-0.36742255091667175,
-0.32781997323036194,
0.21570460498332977,
0.4585745930671692,
-0.1622897833585739,
-0.5444702506065369,
-0.14183242619037628,
0.05240846425294876,
0.6036165952682495,
0.5862975716590881,
-0.30689987540245056,
-0.19490796327590942,
0.2999178171157837,
-0.10516379773616791,
-0.033483702689409256,
0.2704557478427887,
0.037762757390737534,
0.30474838614463806,
-0.1826397180557251,
-0.4002520442008972,
-0.35045263171195984,
-0.3808348476886749,
-0.6902904510498047,
0.29099178314208984,
-0.07342321425676346,
0.15103165805339813,
0.2882453501224518,
-0.26073023676872253,
-0.5668988823890686,
-0.008938577957451344,
-0.17066335678100586,
-0.29591038823127747,
-0.0497128926217556,
0.12740296125411987,
0.3480157256126404,
0.1359209269285202,
0.18225665390491486,
0.18497899174690247,
-0.23054003715515137,
-0.6927575469017029,
0.5156914591789246,
-0.48478445410728455,
1.1372045278549194,
-0.302647203207016,
-0.28880244493484497,
0.687558650970459,
0.533199667930603,
0.021529998630285263,
0.010172322392463684,
0.3694711923599243,
0.2108326107263565,
-0.4009190797805786,
-0.6527531147003174,
0.5216718316078186,
0.29554837942123413,
-0.361735999584198,
0.012693719007074833,
0.27046921849250793,
0.0822831243276596,
-0.2563117742538452,
-0.11901847273111343,
0.06348007917404175,
0.43195831775665283,
0.008774127811193466,
0.3012182116508484,
-0.22259965538978577,
0.5985895991325378,
-0.45406582951545715,
0.12023267149925232,
-0.4222754240036011,
0.3977424204349518,
0.3115185797214508,
0.0722583457827568,
0.568949282169342,
0.36118781566619873,
-0.05996008589863777,
0.7482249736785889,
-0.595009446144104,
-0.06163636967539787,
0.33809158205986023,
0.3230765163898468,
-0.22132962942123413,
-0.43205884099006653,
0.016236072406172752,
-0.3561684191226959,
-0.3032057285308838,
-0.06085789203643799,
0.2759396731853485,
0.39694634079933167,
0.07376653701066971,
-0.09233638644218445,
-0.23616193234920502,
-0.23229068517684937,
-0.7319546341896057,
-0.402682900428772,
0.04079870879650116,
-0.5576874613761902,
0.05043243616819382,
0.35148584842681885,
0.6787416934967041,
0.010084673762321472,
-0.18926271796226501,
0.025371136143803596,
0.013477882370352745,
-0.3090883493423462,
-0.8099442720413208,
0.27788060903549194,
-0.22566546499729156,
-0.06594998389482498,
0.29636070132255554,
0.11996953189373016,
0.2919430136680603,
0.1425751894712448,
-0.5735894441604614,
-0.3590235114097595,
-0.5968599319458008,
0.7699825167655945,
0.5737375020980835,
0.9530506730079651,
0.07068652659654617,
-0.6782901287078857,
0.19173726439476013,
0.11397858709096909,
-0.7178820371627808,
0.2185925841331482,
0.362714946269989,
-0.35446539521217346,
-0.11218347400426865,
0.41198301315307617,
0.3556175231933594,
0.37994682788848877,
-0.33736133575439453,
0.18731649219989777,
-0.06859470158815384,
-0.12082500755786896,
-0.06329882889986038,
-0.17437313497066498,
-0.4418072998523712,
-0.3046055734157562,
0.6295135617256165,
-0.00033707800321280956,
-0.38674989342689514,
0.32084619998931885,
0.32646921277046204,
0.019575297832489014,
0.1466638147830963,
0.8724037408828735,
-0.3136849105358124,
0.049847446382045746,
0.5903807878494263,
-0.14298629760742188,
-0.02366163767874241,
0.1513848602771759,
0.05785193294286728,
-0.030880680307745934,
-0.09269940853118896,
-6.1463398933410645,
0.35285237431526184,
0.10297321528196335,
-0.14855414628982544,
0.02850615419447422,
0.23936700820922852,
0.9845788478851318,
0.40450310707092285,
0.19561262428760529,
-0.023358529433608055,
0.2612808644771576,
0.4719562232494354,
-0.02339565008878708,
-0.36958760023117065,
-0.17047026753425598,
0.11752817034721375,
0.4126284718513489,
-0.03750206530094147,
0.10453738272190094,
0.4599621295928955,
-0.284082293510437,
-0.11837203055620193,
0.09955383837223053,
0.19234389066696167,
0.3496778607368469,
0.6939535140991211,
-0.9711353778839111,
0.7129561305046082,
-0.3357281982898712,
-0.28414463996887207,
0.28878435492515564,
-0.7814337015151978,
-0.0902542918920517,
-0.005052644293755293,
-0.176326185464859,
0.11956346780061722,
-0.33570581674575806,
-0.020670441910624504,
-0.49344611167907715,
-0.019841929897665977,
-0.40910911560058594,
-0.22487396001815796,
-0.22870327532291412,
-0.29415401816368103,
0.4050387144088745,
-0.026200635358691216,
0.03438284248113632,
-0.0035005498211830854,
0.294307142496109,
0.9704279899597168,
-0.08626393973827362,
-0.2622632086277008,
0.10150398313999176,
0.49431025981903076,
0.28136661648750305,
0.03947548195719719,
-0.07841114699840546,
0.5592450499534607,
-0.4811781048774719,
0.20348724722862244,
0.005872686393558979,
-0.265625923871994,
0.24516452848911285,
-0.7213268280029297,
0.27692556381225586,
0.5318352580070496,
-0.28000757098197937,
-0.1070767343044281,
-0.17750251293182373,
-0.3766977787017822,
-0.39280208945274353,
0.11059897392988205,
0.03454063460230827,
-0.8428837656974792,
0.11712959408760071,
-0.4953829348087311,
0.09619744122028351,
0.03716762736439705,
0.23271816968917847,
-0.36194732785224915,
-0.5981383323669434,
-0.41590431332588196,
0.575556755065918,
-0.08707746863365173,
0.3912445604801178,
-0.1966085284948349,
-0.2273058444261551,
-0.07433293759822845,
0.295702189207077,
0.31331244111061096,
0.45102253556251526,
-0.1793310046195984,
0.043650370091199875,
0.30856749415397644,
0.6821459531784058,
0.7721388339996338,
0.17519408464431763,
0.11745797842741013,
0.45445358753204346,
0.1864023208618164,
0.407274454832077,
-0.25668278336524963,
-0.0774637833237648,
-0.4611654281616211,
0.16242846846580505,
-0.1296040117740631,
-0.5875481963157654,
-0.2821657955646515,
0.30611222982406616,
-0.4749755859375,
0.09995405375957489,
0.04419194161891937,
-0.15421490371227264,
0.07603634893894196,
0.881771981716156,
-0.2178114652633667,
0.20132440328598022,
0.06176402419805527,
0.5820643901824951,
-0.24417905509471893,
0.35264891386032104,
0.0025751525536179543,
-0.04915440082550049,
0.18721936643123627,
0.07239552587270737,
-0.5316885709762573,
0.28894585371017456,
0.057838331907987595,
-0.4284936189651489,
-0.1750221848487854,
-0.11560550332069397,
0.8351853489875793,
0.033378880470991135,
-0.030696837231516838,
0.1675589680671692,
-0.1736648976802826,
-0.3688598573207855,
-0.3934285342693329,
0.23603831231594086,
0.15986928343772888,
-0.12790419161319733,
-0.006095379125326872,
-0.6381954550743103,
0.04774012789130211,
0.1548202931880951,
-0.1533229798078537,
-0.07536230981349945,
-0.048088278621435165,
0.24414457380771637,
0.007016377989202738,
-0.0306978952139616,
0.038665562868118286,
0.3230755925178528,
0.010125141590833664,
-1.432297706604004,
-0.03575313836336136,
0.3107208013534546,
0.17334158718585968,
-0.28683191537857056,
-0.25337764620780945,
0.23810283839702606,
-0.22144392132759094,
-1.1215686798095703,
0.022898999974131584,
0.2841245234012604,
-0.5076329708099365,
0.717651903629303,
-0.3165692090988159,
0.014069948345422745,
0.06723713874816895,
-0.04958798363804817,
-0.221376433968544,
0.18015187978744507,
0.2630680203437805,
0.2749166488647461,
-0.10629930347204208,
-0.6613513827323914,
0.0034411291126161814,
0.2650919258594513,
0.5471595525741577,
0.04022828862071037,
0.0046447510831058025,
-0.03360912203788757,
0.5383358597755432,
0.6868066787719727,
0.5521920323371887,
-0.17455698549747467,
-0.4978068172931671,
-0.3206452429294586,
-0.2281252145767212,
0.10860545933246613,
0.03611931577324867,
0.6220590472221375,
0.3553563952445984,
-0.13358967006206512,
0.039295390248298645,
0.3108319342136383,
0.33662986755371094,
0.43266168236732483,
0.1852760910987854,
-0.634410560131073,
0.11844181269407272,
0.32169216871261597,
0.597515881061554,
0.359170526266098,
-0.7992823719978333,
-0.17684096097946167,
-0.21214672923088074,
-0.2546129822731018,
-0.7337749600410461,
-0.0989871621131897,
-0.3005669414997101,
-0.5269070863723755,
0.388755738735199,
-0.2761593163013458,
0.17296962440013885,
0.2756703197956085,
-0.3033868968486786,
0.25303539633750916,
0.23946397006511688,
0.07571285963058472,
0.6025081276893616,
0.08728515356779099,
-0.29520463943481445,
-0.030354470014572144,
0.4215969145298004,
0.8007860779762268,
-0.345157265663147,
0.016533024609088898,
0.17425964772701263,
-0.2592204511165619,
0.011913256719708443,
0.11030405014753342,
0.2971082925796509,
-0.6441980004310608,
-0.08055604994297028,
0.3957769274711609,
-0.3278462886810303,
0.13321039080619812,
0.03447394073009491,
0.1518438458442688,
0.49283409118652344,
0.19255715608596802,
-0.6497108936309814,
0.1319984793663025,
-0.0540492869913578,
-0.005877934396266937,
-0.23054885864257812,
0.2080410122871399,
0.21289612352848053,
0.4517163932323456,
-0.29536136984825134,
-0.050384726375341415,
-0.2415275275707245,
0.1732032597064972,
-0.22286616265773773,
-0.05268185958266258,
-0.5557928681373596,
0.24444621801376343,
0.17844463884830475,
-0.07441185414791107,
-0.2788369357585907,
-0.1930331587791443,
0.004711245186626911,
-0.2684301435947418,
0.13137251138687134,
-0.32764872908592224,
-0.14563661813735962,
0.5188553929328918,
-0.4566989839076996,
-0.1353011131286621,
-0.08002665638923645,
0.023560713976621628,
0.1897987723350525,
-0.11532390117645264,
0.1895233690738678,
-0.33884355425834656,
-0.3343983590602875,
-0.5812553763389587,
0.030137864872813225,
-0.4478558301925659,
-0.23507148027420044,
0.11251864582300186,
-0.017916493117809296,
-0.05180317163467407,
-0.37210598587989807,
-0.0009724273113533854,
-0.17362897098064423,
-0.2965015769004822,
-0.5407609939575195,
-0.22909629344940186,
0.36839643120765686,
-0.2960042953491211,
-0.6785241961479187,
0.2011975347995758,
0.444614976644516,
-0.11253496259450912,
0.36930984258651733,
-0.03133514150977135,
-0.44657373428344727,
-0.2016593962907791,
0.749360978603363,
0.3968085050582886,
-0.22781427204608917,
0.19341866672039032,
-0.12358182668685913,
0.027398129925131798,
0.00646540243178606,
0.23830008506774902,
0.28714480996131897,
0.698739767074585,
0.1752699464559555,
0.0012490276712924242,
0.1909712255001068,
-0.7914614677429199,
-0.22741122543811798,
-0.6219447255134583,
-0.3797234296798706,
0.21676677465438843,
0.23674926161766052,
0.12367214262485504,
0.43596968054771423,
0.7411965131759644,
-0.08495129644870758,
-0.2687622010707855,
0.6131266355514526,
-0.0605318583548069,
0.2949616014957428,
0.019728774204850197,
0.6108906865119934,
0.4592317044734955,
-0.013780428096652031,
-0.2637370228767395,
-0.039466407150030136,
0.14350290596485138,
0.46597519516944885,
0.19262763857841492,
-0.5352200269699097,
-0.17843277752399445,
-0.2758190929889679,
0.5957959294319153,
-0.03727882355451584,
-0.04340755194425583,
-0.03611768037080765,
-0.20254765450954437,
0.3394899070262909,
-0.25343140959739685,
-0.060075920075178146,
0.06703539937734604,
0.19270727038383484,
0.19961531460285187,
0.1209796816110611,
-0.3303123414516449,
-0.11118464916944504,
0.014547728933393955,
0.46881434321403503,
0.053246159106492996,
-0.25316405296325684,
-1.04083251953125,
0.36779582500457764,
-0.23210115730762482,
0.10657206177711487,
0.20982909202575684,
0.4236907958984375,
0.031159020960330963,
-0.3405775725841522,
-0.09302346408367157,
-0.05027036368846893,
0.17255406081676483,
-0.2748061716556549,
-0.11176963895559311,
-0.9306241273880005,
-0.5165423154830933,
0.3292669355869293,
0.23855766654014587,
-0.20725363492965698,
0.08474598079919815,
0.1192290410399437,
0.34327396750450134,
0.5261708498001099,
-0.41680610179901123,
-0.47377949953079224,
-0.27929970622062683,
-0.18097719550132751,
0.1309993714094162,
-0.34272632002830505,
0.009020445868372917,
0.249159038066864,
0.41996848583221436,
0.09863048791885376,
0.6276615858078003,
-0.19241701066493988,
0.011597705073654652,
0.3041624128818512,
0.05809960514307022,
-0.021014755591750145,
0.08410082012414932,
0.5904019474983215,
0.3380974233150482,
-0.1436018943786621,
-0.28073564171791077,
-0.17491696774959564,
-0.38151493668556213,
0.4785008728504181,
-0.20993401110172272,
0.25026512145996094,
-0.297523558139801,
-0.23596835136413574,
-0.9172011017799377,
0.3670608401298523,
-0.12429163604974747,
0.4099781811237335,
-0.22361205518245697,
0.11419031023979187,
0.23309487104415894,
0.09528959542512894,
0.10394234955310822,
-0.08276031911373138,
-0.27453920245170593,
-0.4290030002593994,
-0.39289575815200806,
-0.9929168820381165,
0.02472861483693123,
0.3911338150501251,
-0.3515142798423767,
-0.1232970654964447,
-0.08088133484125137,
0.24131746590137482,
-0.55489182472229,
0.1832880973815918,
0.04793178662657738,
0.16219496726989746,
-0.5053951144218445,
0.041283901780843735,
-0.5935930013656616,
0.263405442237854,
0.5002065896987915,
0.20587165653705597,
-0.5165002346038818,
-0.21097907423973083,
0.024361930787563324,
-0.471299409866333,
0.2645258903503418,
-0.1541835069656372,
0.2389475405216217,
0.4760531783103943,
-0.22651517391204834,
0.24188287556171417,
-0.6566357612609863,
0.08622429519891739,
-0.21522073447704315,
-0.2240513116121292,
-0.0633414089679718,
-0.3987104296684265,
-0.21305376291275024,
0.09725987166166306,
-0.5284493565559387,
-0.09441111236810684,
0.1388029009103775,
-0.3732382655143738
] |
On June 11, 2009, the World Health Organization declared the outbreak of novel influenza A (H1N1) a pandemic. With limited supplies of antivirals and vaccines, countries and individuals are looking at other ways to reduce the spread of pandemic (H1N1) 2009, particularly options that are cost effective and relatively easy to implement. Recent experiences with the 2003 SARS and 2009 H1N1 epidemics have shown that people are willing to wear facemasks to protect themselves against infection; however, little research has been done to quantify the impact of using facemasks in reducing the spread of disease. We construct and analyze a mathematical model for a population in which some people wear facemasks during the pandemic and quantify impact of these masks on the spread of influenza. To estimate the parameter values used for the effectiveness of facemasks, we used available data from studies on N95 respirators and surgical facemasks. The results show that if N95 respirators are only 20% effective in reducing susceptibility and infectivity, only 10% of the population would have to wear them to reduce the number of influenza A (H1N1) cases by 20%. We can conclude from our model that, if worn properly, facemasks are an effective intervention strategy in reducing the spread of pandemic (H1N1) 2009. | [
-0.0005142674781382084,
0.015500791370868683,
-0.015937097370624542,
0.013650137931108475,
0.019013162702322006,
0.003745948662981391,
0.00873471423983574,
0.00992718804627657,
-0.016822010278701782,
-0.0470886267721653,
0.00585838221013546,
0.027373749762773514,
-0.005535667762160301,
-0.005834694020450115,
0.02378450706601143,
-0.010372803546488285,
-0.004970876034349203,
0.04119262099266052,
0.021189942955970764,
0.026021219789981842,
-0.01257262472063303,
0.019761936739087105,
0.010897325351834297,
0.014875562861561775,
0.00027504866011440754,
0.0028290993068367243,
0.0023405863903462887,
-0.021648690104484558,
-0.018539655953645706,
0.013726351782679558,
0.008017361164093018,
0.01888144202530384,
-0.012446366250514984,
0.022205643355846405,
0.004204995930194855,
0.019971046596765518,
-0.0012848195619881153,
0.009060224518179893,
-0.0036890245974063873,
-0.0038725994527339935,
-0.007349878083914518,
-0.018448976799845695,
0.0059283128939569,
0.002774022053927183,
-0.010444626212120056,
0.038252249360084534,
-0.005514712072908878,
-0.006052045151591301,
0.0006414768286049366,
0.0081112589687109,
-0.00042637030128389597,
-0.019788149744272232,
-0.006826239638030529,
0.0003595190355554223,
-0.006346597336232662,
-0.004361090250313282,
0.018826007843017578,
0.030239127576351166,
-0.0426781103014946,
0.03211499750614166,
0.01405082643032074,
0.012411472387611866,
0.001433646772056818,
0.015175987966358662,
-0.010331548750400543,
-0.06640267372131348,
0.026411626487970352,
0.03858523815870285,
0.0027903977315872908,
0.013346640393137932,
0.013798275031149387,
0.012614830397069454,
-0.025070855394005775,
-0.02008191868662834,
-0.04268505424261093,
0.006427230313420296,
0.011280231177806854,
0.02200067602097988,
-0.010215114802122116,
-0.012190775014460087,
0.00615227036178112,
0.002512503182515502,
-0.013360179960727692,
0.027157550677657127,
-0.009087054058909416,
0.019516143947839737,
-0.01986432448029518,
0.006025095470249653,
-0.01229534950107336,
0.01086601335555315,
0.012326902709901333,
-0.018830914050340652,
-0.058628566563129425,
0.01994941011071205,
0.021066132932901382,
-0.017446111887693405,
-0.012786360457539558,
0.007629235275089741,
-0.015375901013612747,
0.0012547046644613147,
0.004609240218997002,
0.02026386559009552,
0.017054405063390732,
0.018969299271702766,
-0.02595028281211853,
0.010535120964050293,
-0.024716414511203766,
-0.005181774031370878,
0.02339130826294422,
0.006021731533110142,
0.008129548281431198,
-0.004446585662662983,
0.03903937712311745,
0.006854210048913956,
-0.037495531141757965,
0.019517995417118073,
-0.01219615712761879,
0.036106862127780914,
0.015325150452554226,
0.00775182107463479,
-0.028991781175136566,
-0.031447820365428925,
0.01679251715540886,
-0.002225147793069482,
-0.0073848143219947815,
0.03559088334441185,
-0.0021681857760995626,
0.014832800254225731,
-0.005399652756750584,
-0.00009953672997653484,
-0.00907716155052185,
-0.004153098911046982,
-0.06095390021800995,
-0.021004820242524147,
0.0035924885887652636,
0.004148009233176708,
-0.016599012538790703,
0.013628879562020302,
-0.003197991754859686,
0.012228934094309807,
-0.019524235278367996,
0.012545285746455193,
-0.004990126937627792,
0.026125095784664154,
0.019395023584365845,
0.0036595615092664957,
-0.011262334883213043,
0.012172176502645016,
0.041116323322057724,
0.02929278463125229,
0.021401451900601387,
0.005476042628288269,
-0.019507668912410736,
-0.010319927707314491,
-0.027500035241246223,
0.020541321486234665,
-0.004058954771608114,
-0.007202844601124525,
-0.027159247547388077,
0.012104456312954426,
-0.010319069027900696,
-0.004224943928420544,
-0.03240528330206871,
0.007922898977994919,
0.044544510543346405,
0.00514420447871089,
0.0297170989215374,
-0.010302175767719746,
-0.011667904444038868,
0.006499839015305042,
-0.009772502817213535,
0.0009924282785505056,
-0.016450513154268265,
0.02002042904496193,
0.014356987550854683,
-0.011425284668803215,
0.0047512841410934925,
0.010265168733894825,
-0.015593274496495724,
0.06582394242286682,
-0.0030683320946991444,
-0.01627255417406559,
-0.001030198996886611,
0.016157526522874832,
-0.001946904230862856,
0.008788671344518661,
0.040132924914360046,
-0.0027943854220211506,
-0.005083275027573109,
-0.019365062937140465,
-0.014558197930455208,
-0.028067216277122498,
-0.003115798346698284,
-0.021588265895843506,
0.006445595994591713,
0.00463083665817976,
-0.0005423789843916893,
0.010985122993588448,
-0.03946617245674133,
0.03440549224615097,
0.020462820306420326,
0.009204542264342308,
0.05764899030327797,
-0.0020572380162775517,
0.0025739227421581745,
0.019592802971601486,
0.009103664197027683,
0.006799420341849327,
0.023325596004724503,
-0.016184557229280472,
0.02072950080037117,
-0.009572467766702175,
0.015246707014739513,
-0.019017618149518967,
-0.017152326181530952,
-0.014538979157805443,
0.023353157564997673,
0.016969038173556328,
0.00811698567122221,
-0.018038839101791382,
0.0026505407877266407,
-0.00388874439522624,
-0.035308435559272766,
0.017270617187023163,
-0.014782948419451714,
0.013335924595594406,
0.013876507058739662,
0.012429983355104923,
-0.0003140745684504509,
0.022689469158649445,
-0.01188676618039608,
0.005001077428460121,
-0.011328141205012798,
-0.024748707190155983,
0.014157982543110847,
-0.01033732108771801,
0.012648430652916431,
-0.02373240515589714,
0.008949733339250088,
-0.02089235931634903,
0.005074740387499332,
-0.011599667370319366,
0.005830028560012579,
-0.01680605858564377,
0.02231626957654953,
0.01071165781468153,
0.03747086971998215,
-0.03338108956813812,
-0.014500290155410767,
0.012866150587797165,
0.00564680527895689,
-0.019499411806464195,
0.02689468488097191,
0.03501515835523605,
0.03738810867071152,
-0.0058464594185352325,
0.033156972378492355,
0.01647135429084301,
0.024968434125185013,
-0.01686246506869793,
0.015676012262701988,
0.0042957039549946785,
-0.029232429340481758,
-0.027530401945114136,
0.014496322721242905,
0.0335388109087944,
0.008378406055271626,
-0.000666473526507616,
0.0038437482435256243,
0.0208907313644886,
0.004753106739372015,
-0.011630014516413212,
-0.005108808632940054,
-0.08092193305492401,
-0.014999291859567165,
0.02445206791162491,
-0.004955504555255175,
0.007151214871555567,
-0.003884752281010151,
-0.00284394808113575,
0.011787962168455124,
-0.017401864752173424,
0.02796829119324684,
-0.008907744660973549,
0.027441885322332382,
0.002960492856800556,
0.014752748422324657,
-0.024189623072743416,
-0.0033822597470134497,
0.007000802084803581,
0.025828037410974503,
-0.013063542544841766,
0.017093732953071594,
0.004400826990604401,
0.009408524259924889,
0.05906281620264053,
-0.03399296849966049,
-0.03164795786142349,
-0.010417299345135689,
-0.0023864335380494595,
-0.004678649362176657,
0.009140736423432827,
0.012756401672959328,
0.012770572677254677,
-0.028097722679376602,
-0.012419654056429863,
-0.010008125565946102,
0.0329536497592926,
-0.005456422921270132,
0.00958525575697422,
-0.009789818897843361,
0.006434125825762749,
0.008376137353479862,
-0.012511299923062325,
0.007433626800775528,
0.012587932869791985,
0.010095883160829544,
0.008349149487912655,
-0.005942492745816708,
0.012851224280893803,
0.013609293848276138,
0.014760242775082588,
0.0099894218146801,
-0.03078918345272541,
-0.022140657529234886,
-0.003573041409254074,
0.010643364861607552,
-0.016410639509558678,
0.003851779503747821,
0.008306248113512993,
0.006198318675160408,
-0.016454607248306274,
-0.0054833851754665375,
-0.03208928555250168,
0.04339735582470894,
0.021727420389652252,
-0.0011248616501688957,
-0.05029764398932457,
-0.004371556453406811,
-0.00168917840346694,
0.006375838071107864,
-0.020734362304210663,
0.015984268859028816,
-0.0034274347126483917,
0.014388752169907093,
0.028417067602276802,
-0.015101448632776737,
0.014138855040073395,
-0.00379061046987772,
-0.014097223989665508,
-0.006153565365821123,
0.01301987562328577,
0.013029089197516441,
-0.005045842379331589,
0.019837267696857452,
-0.00820966623723507,
0.014270259998738766,
-0.009337671101093292,
0.023082111030817032,
0.015244169160723686,
-0.028808634728193283,
0.008414387702941895,
-0.022383535280823708,
0.00013519544154405594,
-0.006959749385714531,
-0.02166849933564663,
0.011937767267227173,
-0.013580277562141418,
-0.004073010291904211,
0.005635543260723352,
-0.001036984845995903,
0.0038700331933796406,
0.00882515124976635,
-0.02119654230773449,
-0.02141602896153927,
0.020445652306079865,
-0.012837288901209831,
0.008032620884478092,
0.01223666314035654,
0.024392910301685333,
-0.022545522078871727,
-0.02658640593290329,
-0.02204679511487484,
-0.0018185339868068695,
0.00776714226230979,
0.0036462184507399797,
-0.017153063789010048,
0.009136994369328022,
0.003236847696825862,
0.013776740059256554,
-0.019418979063630104,
0.07171249389648438,
0.00627052690833807,
0.012952768243849277,
-0.019258638843894005,
0.035314690321683884,
-0.013918845914304256,
0.018883224576711655,
-0.007608314976096153,
-0.001213972456753254,
-0.00317207258194685,
0.012671409174799919,
-0.028996773064136505,
0.008922341279685497,
-0.02419288083910942,
-0.022624962031841278,
-0.014139249920845032,
0.01587333343923092,
-0.04369393736124039,
0.0304696224629879,
-0.007832959294319153,
0.006416326854377985,
-0.008477991446852684,
-0.0026348321698606014,
-0.008310076780617237,
0.013029580935835838,
0.002888171002268791,
0.00939720869064331,
-0.012267490848898888,
-0.006820930168032646,
0.0019238968379795551,
0.039077624678611755,
0.024931462481617928,
-0.004419337958097458,
-0.01084431353956461,
-0.007882984355092049,
0.00478331558406353,
-0.008836776949465275,
0.015854842960834503,
0.002072985051199794,
-0.005083192139863968,
0.004726303741335869,
-0.01581912860274315,
-0.009284846484661102,
0.020708460360765457,
0.023012675344944,
0.013150216080248356,
-0.010614925064146519,
-0.011397402733564377,
-0.010799531824886799,
0.030168773606419563,
-0.0015352636110037565,
0.009754382073879242,
0.009996695443987846,
0.008756023831665516,
-0.002644780557602644,
0.02498449943959713,
-0.010133519768714905,
0.013730749487876892,
0.020843539386987686,
-0.019497442990541458,
-0.01404874213039875,
-0.013288933783769608,
-0.002515803324058652,
0.009950192645192146,
0.003756073070690036,
-0.010818387381732464,
-0.024119149893522263,
0.006737681571394205,
-0.023004429414868355,
-0.012525093741714954,
-0.0160983819514513,
-0.005545437335968018,
0.01498468965291977,
-0.0006239286158233881,
-0.04714610055088997,
0.00004138017538934946,
-0.04456985369324684,
0.01729007065296173,
-0.008361740969121456,
0.022128866985440254,
-0.009569214656949043,
-0.016606613993644714,
0.01776152104139328,
-0.00035904417745769024,
-0.01236436702311039,
0.0233236663043499,
-0.009429680183529854,
-0.07403101772069931,
-0.00340759614482522,
-0.002936295233666897,
-0.00902698002755642,
-0.0068798060528934,
-0.0026721181347966194,
-0.03163139149546623,
0.021385153755545616,
-0.025052381679415703,
-0.0026894845068454742,
-0.028645005077123642,
0.004281732253730297,
0.05259618163108826,
0.027702467516064644,
0.01827167719602585,
0.0025403699837625027,
-0.017285168170928955,
-0.0001895086606964469,
-0.0027609793469309807,
-0.017242426052689552,
-0.013706384226679802,
0.005354791879653931,
-0.04094642400741577,
-0.018378006294369698,
0.006124344654381275,
-0.08043807744979858,
-0.0033904346637427807,
0.013416837900876999,
-0.05108559876680374,
0.008168740198016167,
-0.013357274234294891,
0.03030921332538128,
-0.043191343545913696,
-0.025442877784371376,
-0.016204699873924255,
-0.022504858672618866,
0.0038244626484811306,
0.010743252001702785,
-0.017176032066345215,
0.02872076816856861,
-0.008617211133241653,
0.03352011740207672,
0.018269114196300507,
0.02104312926530838,
0.0012382242130115628,
0.024715816602110863,
0.010242090560495853,
-0.008666533045470715,
-0.008457598276436329,
-0.012532444670796394,
0.0024741622619330883,
-0.009324915707111359,
0.010569092817604542,
0.027603555470705032,
0.007368654012680054,
-0.00523647665977478,
0.014107652939856052,
0.008378123864531517,
0.014698963612318039,
0.034836553037166595,
-0.00800024438649416,
0.016529317945241928,
-0.03268195688724518,
0.008869526907801628,
0.01522893738001585,
-0.014951734803617,
0.023383809253573418,
-0.029430784285068512,
0.013042813166975975,
0.0006422430742532015,
0.007501516491174698,
0.01007811352610588,
-0.0031961374916136265,
0.023407259956002235,
-0.01293996162712574,
-0.006696384400129318,
-0.006577066145837307,
0.0012149339308962226,
-0.009030481800436974,
0.02011895552277565,
-0.00481767114251852,
-0.0020271025132387877,
-0.005152931436896324,
-0.007052924484014511,
0.01595945842564106,
-0.024081962183117867,
0.0239272378385067,
0.005808951798826456,
0.07051117718219757,
-0.03066098317503929,
0.020913613960146904,
-0.0016661925474181771,
-0.009894607588648796,
0.002034580335021019,
-0.00941567774862051,
-0.010390732437372208,
-0.024274710565805435,
-0.000303580891340971,
0.029427967965602875,
-0.008360321633517742,
0.005078806541860104,
0.008602673187851906,
0.0009546559303998947,
-0.010005040094256401,
0.018432224169373512,
-0.039340078830718994,
-0.002233735751360655,
0.0018551954999566078,
-0.014523993246257305,
-0.0017409996362403035,
-0.012714020907878876,
0.007016981951892376,
0.021182645112276077,
-0.005920163821429014,
-0.05483546108007431,
0.016906842589378357,
-0.010668623261153698,
0.01472370233386755,
0.015448000282049179,
-0.014448797330260277,
0.014347339980304241,
-0.01839384250342846,
0.013619020581245422,
-0.018893640488386154,
0.04835934564471245,
0.008085690438747406,
0.007953932508826256,
0.02753494307398796,
0.000928955152630806,
-0.002438326831907034,
0.008503417484462261,
-0.023719921708106995,
0.022757045924663544,
-0.04246346652507782,
-0.0020776670426130295,
0.013758833520114422,
0.018302027136087418,
0.01575622893869877,
0.008378587663173676,
0.013629564084112644,
-0.008474361151456833,
0.0025313622318208218,
-0.00972493551671505,
0.042795099318027496,
-0.006198134273290634,
0.030423179268836975,
-0.011641725897789001,
0.018378227949142456,
-0.016198016703128815,
-0.014727255329489708,
-0.021502312272787094,
-0.021590672433376312,
0.008706803433597088,
-0.0007209405303001404,
0.006611510179936886,
-0.008722551167011261,
0.02004958875477314,
0.010023745708167553,
-0.015275132842361927,
0.02012418955564499,
0.003847916144877672,
0.002242561662569642,
0.01369628868997097,
0.028304120525717735,
0.0191299207508564,
-0.006534023210406303,
-0.004069062881171703,
0.003265524748712778,
-0.00505209993571043,
0.010673163458704948,
0.01995948702096939,
0.014872940257191658,
-0.008958803489804268,
-0.011889899149537086,
0.011961926706135273,
-0.02338850125670433,
-0.012918059714138508,
0.012715836986899376,
0.008044488728046417,
0.0164980236440897,
0.001034522894769907,
-0.0024496782571077347,
0.015285283327102661,
0.0348120778799057,
0.008136258460581303,
0.01462230272591114,
0.003143901005387306,
0.0003088399535045028,
-0.01358158141374588,
-0.0011097131064161658,
0.005955847445875406,
0.0015861261636018753,
0.004221544601023197,
-0.007439430337399244,
0.021120121702551842,
0.04135201871395111,
-0.0011641213204711676,
0.02724781259894371,
0.013016736134886742,
0.015309140086174011,
0.009360294789075851,
-0.025969352573156357,
0.012174290604889393,
0.004586480557918549,
-0.014702620916068554,
0.002577658277004957,
-0.014375013299286366,
-0.009354231879115105,
-0.023672636598348618,
-0.025402436032891273,
0.014797572046518326,
0.035248979926109314,
-0.023756755515933037,
-0.002436175011098385,
-0.004024921916425228,
-0.022933490574359894,
-0.01927073299884796,
0.03323382884263992,
0.0072608767077326775,
-0.025762898847460747,
-0.015348853543400764,
0.027648448944091797,
0.00837881863117218,
-0.007058626972138882,
0.027535583823919296,
-0.004734995774924755,
0.0008268646197393537,
-0.01741287112236023,
-0.008608962409198284,
0.014943534508347511,
0.005902973003685474,
-0.0008551052305847406,
0.011797602288424969,
0.009656996466219425,
-0.002316882833838463,
-0.029103141278028488,
0.012427319772541523,
0.005904574878513813,
-0.0026927893050014973,
0.008923294022679329,
0.008177460171282291,
-0.0022880067117512226,
-0.02062215283513069,
-0.002551571000367403,
-0.0010571349412202835,
-0.01374557614326477,
-0.00940729957073927,
-0.0029833675362169743,
-0.004243812989443541,
0.014700531959533691,
0.0014854255132377148,
0.011198373511433601,
-0.0003582552308216691,
-0.017408296465873718,
0.007723573129624128,
-0.014800187200307846,
0.011953463777899742,
0.03622831031680107,
-0.020336704328656197,
-0.0178570207208395,
0.0061563728377223015,
-0.007996521890163422,
-0.014432061463594437,
-0.028915707021951675,
-0.019896753132343292,
-0.00041510933078825474,
-0.038757458329200745,
0.037477679550647736,
0.0013632248155772686,
0.03029581904411316,
0.0012003649026155472,
-0.00832388922572136,
-0.0046247621066868305,
0.014477037824690342,
-0.018857387825846672,
0.03680526465177536,
0.025950465351343155,
-0.005138611886650324,
-0.0032749446108937263,
-0.023243367671966553,
-0.0019855168648064137,
-0.0023690913803875446,
0.010816747322678566,
-0.020494643598794937,
-0.008445924147963524,
-0.010425075888633728,
0.008964120410382748,
0.013975844718515873,
0.010298231616616249,
0.012999450787901878
] | [
0.009553427807986736,
0.2546652555465698,
-0.003138813888654113,
-0.40178588032722473,
-0.29666396975517273,
-0.24862730503082275,
0.7202388644218445,
0.4740524888038635,
-0.38543209433555603,
-0.39707696437835693,
-0.1761762946844101,
0.11688201129436493,
-0.7718299627304077,
0.6285989284515381,
-0.25087425112724304,
0.11934785544872284,
0.6292791962623596,
0.47555607557296753,
-0.3579195439815521,
0.19703413546085358,
-0.3003932237625122,
-0.6315023303031921,
0.055020879954099655,
0.2597810626029968,
0.09930182248353958,
-0.5624603629112244,
0.25175991654396057,
-0.023006321862339973,
0.6282511949539185,
0.36324211955070496,
0.3303194046020508,
0.45804864168167114,
0.31099003553390503,
-0.2436980903148651,
-0.3739335238933563,
-0.06496508419513702,
-0.45759716629981995,
-0.15120944380760193,
-0.497068852186203,
-0.16483670473098755,
-0.4745400846004486,
-0.2765745520591736,
-0.27434176206588745,
0.20887473225593567,
0.20091626048088074,
-0.2469543218612671,
-1.2368179559707642,
0.5774884223937988,
-0.09314748644828796,
0.2876739501953125,
0.25983288884162903,
-0.056094370782375336,
-0.28676837682724,
0.2597728669643402,
-0.05382802337408066,
0.12330154329538345,
-0.6643062829971313,
-0.048300519585609436,
-0.21260200440883636,
-0.4071156084537506,
0.27624568343162537,
-0.7218106389045715,
0.06622424721717834,
0.25823211669921875,
-0.42523694038391113,
0.581684947013855,
0.3456084728240967,
0.5036376118659973,
-0.3316743075847626,
-0.5530894994735718,
0.01502417866140604,
-0.5077268481254578,
-0.21005931496620178,
-0.32783085107803345,
-0.21828347444534302,
-0.19962701201438904,
-0.14096549153327942,
-0.5411871671676636,
0.40549707412719727,
0.2901447117328644,
0.19096219539642334,
-0.14959833025932312,
0.23414228856563568,
-0.43218302726745605,
0.11440303921699524,
0.0635179802775383,
0.1712837964296341,
0.6629781126976013,
0.1434859335422516,
0.10771270841360092,
0.21483708918094635,
0.12531132996082306,
1.0993818044662476,
0.16417941451072693,
-0.2677648365497589,
0.143088698387146,
-0.21261925995349884,
0.015080872923135757,
0.1288164258003235,
-0.526284396648407,
-0.003535955213010311,
-0.08278143405914307,
0.025699688121676445,
-0.2261945903301239,
-0.3352038860321045,
-0.5191562175750732,
0.24352341890335083,
-0.6001942753791809,
0.2419169694185257,
-0.25138482451438904,
-0.24343331158161163,
0.12848420441150665,
0.034869372844696045,
-0.23614448308944702,
-0.6193435192108154,
0.7587389349937439,
0.39652296900749207,
-0.5858967304229736,
0.30071261525154114,
-0.31258535385131836,
0.21892257034778595,
0.5941057801246643,
-0.057173922657966614,
0.06000266596674919,
0.16681616008281708,
0.12043312937021255,
0.3371736407279968,
0.13985663652420044,
-0.16832244396209717,
0.5269511342048645,
-0.10138463228940964,
0.7996816039085388,
-0.5012615323066711,
-0.30942291021347046,
0.22254320979118347,
-0.07988685369491577,
0.18126320838928223,
0.2474040538072586,
0.30552464723587036,
-0.15094095468521118,
-0.3274918794631958,
-0.3743993043899536,
-0.6583518981933594,
0.25771644711494446,
0.3115508258342743,
-0.18980003893375397,
-0.18509098887443542,
-0.05809692665934563,
-0.3178898096084595,
-0.5685831308364868,
-0.25547605752944946,
-0.7317802309989929,
-0.25865408778190613,
0.1402493566274643,
0.41528093814849854,
0.5604259967803955,
-0.3688499331474304,
-0.1538335531949997,
0.4247187077999115,
-0.02392588183283806,
0.8711360096931458,
0.12492260336875916,
-0.2391255646944046,
0.13038189709186554,
0.39531007409095764,
0.21129311621189117,
-0.30258098244667053,
0.5145483613014221,
0.15975424647331238,
-0.36218875646591187,
-0.20805448293685913,
0.017232323065400124,
0.2387332171201706,
-0.37020888924598694,
-0.06625211983919144,
0.20153726637363434,
0.4460986256599426,
-0.05719979107379913,
0.45380663871765137,
0.49740180373191833,
-0.5749238729476929,
-0.2520790696144104,
0.5156568288803101,
0.04457784816622734,
0.5141264200210571,
0.1498136669397354,
0.2827758491039276,
0.15661123394966125,
0.19385702908039093,
0.21518629789352417,
-0.47032037377357483,
-0.23768091201782227,
0.5961188077926636,
-0.5596859455108643,
1.1116715669631958,
-0.012835949659347534,
-0.36871933937072754,
1.6998097896575928,
-0.2137250006198883,
0.47448086738586426,
0.09296632558107376,
0.2538137137889862,
0.7388300895690918,
-0.24071601033210754,
-0.48552846908569336,
0.06884151697158813,
0.2683384120464325,
0.09486477822065353,
-0.2883385419845581,
0.0057336511090397835,
0.454232394695282,
-0.6129494905471802,
0.01197471097111702,
0.010881389491260052,
0.3044010400772095,
0.13447940349578857,
-0.09248034656047821,
-0.2970641255378723,
0.010937133803963661,
-0.6327676177024841,
-0.006663335952907801,
-0.307352751493454,
-0.30876484513282776,
-0.03031294420361519,
0.40047040581703186,
0.583711564540863,
0.23338864743709564,
-0.17463330924510956,
0.9639651775360107,
-0.8887884616851807,
-0.15064895153045654,
-0.12842153012752533,
0.582520604133606,
-0.31956401467323303,
-0.3993503749370575,
0.2387676239013672,
0.13571152091026306,
-0.28525710105895996,
0.1549673229455948,
-0.1778108775615692,
0.47994837164878845,
-0.3748612105846405,
-0.16934014856815338,
0.3217222988605499,
0.07723381370306015,
0.053976405411958694,
0.055329445749521255,
0.00033575508859939873,
-0.6207236051559448,
-0.11293070763349533,
0.3420531749725342,
0.21237173676490784,
0.2805265784263611,
-0.12981796264648438,
-0.042882245033979416,
0.18671634793281555,
0.18950733542442322,
0.13934656977653503,
0.16200608015060425,
-0.047549884766340256,
-0.07973085343837738,
0.10180270671844482,
0.27144357562065125,
0.6380061507225037,
-0.14352451264858246,
-0.54216468334198,
-0.603029727935791,
0.138718381524086,
0.2952844500541687,
0.3029084801673889,
0.8022589683532715,
-0.414376437664032,
-0.3834288418292999,
0.15195932984352112,
0.48224952816963196,
-0.5124048590660095,
0.027876107022166252,
1.1094192266464233,
-0.6077499985694885,
0.2115328013896942,
-0.18444868922233582,
0.8252590298652649,
0.8271306753158569,
-0.8108533620834351,
-0.2770668566226959,
-0.16658426821231842,
-0.07251228392124176,
-0.40307605266571045,
-0.5765199661254883,
-0.051084455102682114,
-0.1184876412153244,
0.3435657322406769,
-0.1803039312362671,
0.03626803308725357,
-0.34738296270370483,
-0.193418487906456,
-0.07447590678930283,
0.09790357202291489,
0.5067474842071533,
0.27205803990364075,
-0.4382418692111969,
0.181675523519516,
-0.07857224345207214,
-0.49014586210250854,
-0.09071996808052063,
0.2667545974254608,
-0.04675060138106346,
-0.05839468538761139,
-6.095362186431885,
0.15872278809547424,
0.10830964893102646,
-0.37797844409942627,
-0.5560600161552429,
0.36411261558532715,
0.6651325225830078,
-0.012381104752421379,
0.17629945278167725,
0.004288604483008385,
1.0112879276275635,
0.1859002709388733,
0.09107446670532227,
0.2653365731239319,
-0.38884443044662476,
0.3419571816921234,
-0.1704634577035904,
-0.12442033737897873,
0.021246058866381645,
0.141368567943573,
0.24141353368759155,
-0.11103391647338867,
0.035894013941287994,
-0.07606454938650131,
0.38433969020843506,
0.2664144039154053,
-0.630575954914093,
0.4942537546157837,
-0.1910824477672577,
-0.0642542615532875,
0.7004182934761047,
-0.5324341654777527,
-0.03139844164252281,
-0.06459672749042511,
-0.3572879731655121,
-0.1383432000875473,
0.1298004388809204,
-0.4820857644081116,
-0.4210158884525299,
-0.21210823953151703,
-0.04287052899599075,
-0.1820196956396103,
-0.25986069440841675,
-0.33709144592285156,
0.36723995208740234,
-0.18505488336086273,
0.16050632297992706,
0.2839815616607666,
-0.19680912792682648,
0.20125269889831543,
0.3414327800273895,
-0.06615074723958969,
-0.22917641699314117,
0.4701491594314575,
0.34470251202583313,
0.2607630491256714,
-0.22790443897247314,
0.2269737869501114,
-0.37891754508018494,
-0.17732392251491547,
0.016383083537220955,
0.00840427540242672,
0.12322751432657242,
-0.5817455053329468,
0.5067803263664246,
-0.01394402701407671,
-0.7821113467216492,
-0.585271418094635,
0.15927021205425262,
0.06729109585285187,
-0.26049259305000305,
0.07550916075706482,
0.141143336892128,
-0.647174060344696,
-0.11417828500270844,
-0.6711922287940979,
0.22626622021198273,
-0.225606769323349,
-0.018810570240020752,
-0.5776819586753845,
-0.4643889367580414,
-0.44231507182121277,
0.16081903874874115,
-0.38914114236831665,
0.22608235478401184,
-0.3949539065361023,
0.14495620131492615,
0.12977397441864014,
0.21256528794765472,
0.14179392158985138,
0.9375172257423401,
-0.2206391841173172,
-0.0649341344833374,
0.048892755061388016,
-0.05547214299440384,
0.499894917011261,
0.2426425814628601,
0.1467907428741455,
0.3408190608024597,
0.4813203811645508,
-0.10404041409492493,
-0.2430950105190277,
-0.03618748486042023,
-0.562931478023529,
0.0255169328302145,
-0.00312113668769598,
-0.272979199886322,
-0.01053173840045929,
0.8550798892974854,
-0.6789279580116272,
-0.037839777767658234,
0.16829368472099304,
0.0054708183743059635,
-0.34083470702171326,
0.47607967257499695,
-0.26433077454566956,
0.6545965075492859,
0.2784968316555023,
0.5849319696426392,
-0.29921895265579224,
0.5291988253593445,
0.4158516526222229,
-0.4966234266757965,
0.32679465413093567,
0.4159078896045685,
-0.01886027678847313,
0.0325169563293457,
0.32601457834243774,
-0.3028256893157959,
-0.41520801186561584,
0.4432169497013092,
0.4435378611087799,
-0.09282093495130539,
-0.1398598998785019,
0.6593217253684998,
-0.1928764283657074,
-0.5857755541801453,
-0.28728294372558594,
0.11708047986030579,
-0.041187483817338943,
0.09010457247495651,
0.2707958519458771,
-0.1317719966173172,
-0.06241573393344879,
-0.05650436133146286,
-0.014476754702627659,
0.08406104147434235,
-0.3362439274787903,
-0.030648689717054367,
0.038048259913921356,
0.04036470875144005,
-0.04527638852596283,
-0.26983916759490967,
0.0837525799870491,
-0.684482216835022,
0.5501453876495361,
0.8822349309921265,
0.24972456693649292,
-0.8097360730171204,
-0.6489779353141785,
0.20261496305465698,
0.21350735425949097,
-0.7821049094200134,
-0.12849558889865875,
0.19082553684711456,
-0.2849844992160797,
0.46285051107406616,
-0.2944983243942261,
-0.02546790800988674,
0.10176052153110504,
-0.0158293005079031,
-0.3256874084472656,
-0.6084765195846558,
0.2158123254776001,
0.15437860786914825,
0.3678329885005951,
-0.2834349274635315,
-0.19539879262447357,
-0.03139229118824005,
0.49723923206329346,
0.18078355491161346,
-0.1733858287334442,
-0.397266685962677,
0.27616602182388306,
0.24318568408489227,
0.22476470470428467,
-0.12266070395708084,
-0.3254571557044983,
-0.2606073021888733,
-0.11664572358131409,
0.3922492265701294,
-0.03396094962954521,
-0.08798971027135849,
0.019997691735625267,
-0.27417293190956116,
-0.4200792908668518,
-0.3274323344230652,
-0.17161625623703003,
0.23341724276542664,
0.08901574462652206,
-0.010865947231650352,
0.290364146232605,
-0.5027832984924316,
-0.33835849165916443,
0.28319087624549866,
-0.6456083059310913,
0.11104784160852432,
-0.028616078197956085,
0.18489480018615723,
0.01508249994367361,
0.07539641857147217,
-0.3293916583061218,
-0.07291737198829651,
0.8150280117988586,
0.1868283599615097,
0.3346712589263916,
-0.28729069232940674,
-0.42664918303489685,
-0.22662585973739624,
0.192866712808609,
-0.33564016222953796,
0.19558560848236084,
-0.254030704498291,
-0.15806882083415985,
-0.34125053882598877,
0.6016552448272705,
0.19721423089504242,
-0.490385502576828,
0.12234117835760117,
-0.1409720778465271,
0.008036847226321697,
0.08941783010959625,
-0.10834235697984695,
0.4493880867958069,
-0.5148996114730835,
-0.16867703199386597,
0.3977147340774536,
-0.3936639428138733,
0.23192842304706573,
0.7353149056434631,
-0.08167626708745956,
0.2992140054702759,
-0.08126392960548401,
-0.5177670121192932,
-0.3300633728504181,
-0.4047550559043884,
-0.3117353916168213,
-0.5493111610412598,
-0.04867233335971832,
0.30462920665740967,
-0.3523663580417633,
-0.06343530118465424,
-0.06258873641490936,
-0.4114190638065338,
-0.030348818749189377,
0.009127619676291943,
0.0029049839358776808,
-0.20418204367160797,
-0.12176689505577087,
-0.381884902715683,
-0.09737895429134369,
0.27003782987594604,
-0.1104205772280693,
-0.029909653589129448,
0.3441855013370514,
-0.004921117797493935,
-0.5371574759483337,
-0.2399654984474182,
-0.046313464641571045,
-0.34397241473197937,
-0.05838866904377937,
0.028238775208592415,
0.2514728903770447,
0.332130491733551,
0.18999893963336945,
0.05603693425655365,
-0.4254028797149658,
-0.387745201587677,
-0.2514553666114807,
0.4522099792957306,
-0.3647719919681549,
-0.33112233877182007,
-0.12522049248218536,
-0.24100689589977264,
0.24992597103118896,
-0.7442976832389832,
0.5152235627174377,
-0.2672419846057892,
-0.16647937893867493,
-0.4714335501194,
-0.005725891795009375,
0.66621333360672,
-0.5756602883338928,
-0.2640670835971832,
-0.2538135051727295,
0.21364954113960266,
0.016190681606531143,
0.783222496509552,
-0.1572764366865158,
-0.17929859459400177,
-0.31141117215156555,
0.5881738066673279,
0.5035826563835144,
-0.2694513499736786,
-0.075499027967453,
0.07525084167718887,
0.0034002538304775953,
0.27666133642196655,
0.13135504722595215,
0.39659807085990906,
0.24115878343582153,
0.3035547733306885,
0.03524932265281677,
0.5122942328453064,
-0.8011522889137268,
0.3865657448768616,
-0.3702430725097656,
-0.2510794401168823,
0.12845385074615479,
-0.2521059513092041,
-0.009529199451208115,
0.665364146232605,
-0.048964813351631165,
-0.2280425876379013,
-0.743191123008728,
0.38677504658699036,
-0.02343021333217621,
0.6111034750938416,
0.2142847776412964,
0.6097962856292725,
0.503451406955719,
0.30488479137420654,
-0.24878822267055511,
0.06800507009029388,
-0.14863772690296173,
-0.08470050990581512,
0.353512704372406,
-0.6535153388977051,
-0.22545450925827026,
0.10042648017406464,
1.264349341392517,
-0.12646377086639404,
0.0015689687570556998,
-0.02655215375125408,
0.011139106936752796,
0.31301629543304443,
0.039310380816459656,
0.32873234152793884,
0.5656201243400574,
-0.0877532958984375,
0.41983625292778015,
0.2220788300037384,
-0.007758162450045347,
0.15607106685638428,
-0.14524690806865692,
0.05340014770627022,
-0.15326376259326935,
-0.45014485716819763,
-0.37852415442466736,
-0.10924892127513885,
0.20397956669330597,
0.176409050822258,
-0.016276760026812553,
0.5846759676933289,
0.059792615473270416,
0.22708375751972198,
0.32659247517585754,
0.43969905376434326,
0.10159153491258621,
-0.18337951600551605,
0.011333778500556946,
-0.21546730399131775,
-0.22972194850444794,
0.2511754333972931,
0.20889578759670258,
0.14867372810840607,
0.15222448110580444,
0.004579616244882345,
0.11662086099386215,
0.2822381854057312,
-0.565389096736908,
-0.5593341588973999,
-0.2803739309310913,
-0.3958301544189453,
-0.27093812823295593,
-0.2396872639656067,
-0.28928956389427185,
0.11035566031932831,
0.07807009667158127,
-0.29258623719215393,
-0.13723251223564148,
-0.1144939512014389,
0.08625788241624832,
0.04972238466143608,
0.19807817041873932,
-0.10539994388818741,
0.24897009134292603,
0.5442134737968445,
-0.11444969475269318,
0.4779300391674042,
0.182157963514328,
-0.2844768464565277,
-0.33594149351119995,
0.4854431748390198,
-0.7416710257530212,
0.6202577948570251,
0.07822705805301666,
-0.09053986519575119,
-0.5526239275932312,
-0.01244948897510767,
0.2798018455505371,
0.2052515298128128,
-0.1905096173286438,
0.29902952909469604,
-0.4454303979873657,
-0.12701106071472168,
0.6356950998306274,
-0.2842761278152466,
-0.2865924835205078,
-0.8191865682601929,
-0.26818951964378357,
-0.6713215708732605,
-0.08391817659139633,
-0.03366698697209358,
-0.11563313752412796,
0.026009920984506607,
0.5236626267433167,
0.4648517668247223,
0.11925975233316422,
0.6509950757026672,
-0.34656330943107605,
0.25887203216552734,
-0.2036098837852478,
0.24084597826004028,
-0.8537808060646057,
0.04043316841125488,
0.6027092933654785,
0.24940797686576843,
-0.11130643635988235,
-0.07390754669904709,
0.08057772368192673,
-0.3243738114833832,
0.23490500450134277,
0.03589947521686554,
0.34177830815315247,
0.28677499294281006,
-0.26452720165252686,
-0.0070870439521968365,
-0.37093573808670044,
0.06366395205259323,
-0.049595028162002563,
0.21171525120735168,
0.0017095602815970778,
-0.3676588237285614,
0.11383187770843506,
-0.04276884347200394,
0.12848332524299622,
-0.4504453241825104,
0.15627126395702362,
-0.0004159944364801049
] |
The basic reproduction number, R(0), a summary measure of the transmission potential of an infectious disease, is estimated from early epidemic growth rate, but a likelihood-based method for the estimation has yet to be developed. The present study corrects the concept of the actual reproduction number, offering a simple framework for estimating R(0) without assuming exponential growth of cases. The proposed method is applied to the HIV epidemic in European countries, yielding R(0) values ranging from 3.60 to 3.74, consistent with those based on the Euler-Lotka equation. The method also permits calculating the expected value of R(0) using a spreadsheet. | [
-0.002007248578593135,
0.02717028558254242,
-0.017055120319128036,
0.006176868453621864,
0.00850258395075798,
-0.0263040903955698,
0.008981915190815926,
-0.0222344771027565,
-0.013925433158874512,
-0.03556562215089798,
-0.004563166294246912,
0.01897319406270981,
0.002547552576288581,
0.019565019756555557,
-0.0032264087349176407,
0.023628706112504005,
-0.01480672974139452,
-0.00023376778699457645,
0.010702854953706264,
-0.010367050766944885,
-0.02017219364643097,
-0.003100900212302804,
0.010495783761143684,
-0.027775509282946587,
-0.013835806399583817,
0.04254855215549469,
0.006884329486638308,
-0.01652553491294384,
0.02349391020834446,
-0.025786779820919037,
0.010903734713792801,
0.017308581620454788,
-0.014486243948340416,
0.0395113080739975,
0.017833402380347252,
-0.011219684034585953,
-0.0020549180917441845,
0.012365540489554405,
0.007261359598487616,
-0.00417302455753088,
0.018163304775953293,
-0.01684463769197464,
0.018561434000730515,
-0.005592355038970709,
-0.005814097821712494,
-0.015523150563240051,
-0.007292483001947403,
-0.0009985851356759667,
-0.010965188965201378,
0.009993336163461208,
-0.013333776034414768,
-0.008484662510454655,
-0.01655092090368271,
0.009248550049960613,
-0.005571392830461264,
-0.005074971821159124,
0.0173917505890131,
0.026066120713949203,
-0.02992982044816017,
0.009821000508964062,
0.006209327839314938,
0.0020542554557323456,
-0.00364795234054327,
-0.017727799713611603,
-0.02801533229649067,
-0.0671173483133316,
-0.016510536894202232,
0.014233672991394997,
0.010946381837129593,
-0.018510770052671432,
-0.048782892525196075,
0.009028652682900429,
0.013987265527248383,
-0.016765858978033066,
-0.03577020391821861,
-0.015381362289190292,
-0.00649041123688221,
0.023253612220287323,
-0.013876951299607754,
-0.009783264249563217,
0.030223112553358078,
0.009478830732405186,
0.03149653971195221,
0.025468861684203148,
-0.022740282118320465,
0.00889098085463047,
-0.028329238295555115,
0.005666285753250122,
-0.017395135015249252,
-0.019746840000152588,
-0.0016973947640508413,
-0.021797161549329758,
-0.025383342057466507,
0.006777479778975248,
-0.041639868170022964,
-0.00673178443685174,
-0.003978444263339043,
-0.015106355771422386,
-0.015843547880649567,
-0.012768431566655636,
-0.00732254097238183,
0.027212250977754593,
0.007956083863973618,
0.05169723182916641,
-0.014786197803914547,
0.013302051462233067,
-0.0002762663643807173,
0.00762922503054142,
0.03985590487718582,
-0.003433139994740486,
-0.000656852382235229,
-0.017989668995141983,
0.03409712761640549,
0.0013898916076868773,
0.024298880249261856,
0.0021465651225298643,
0.00951914768666029,
0.011768341064453125,
0.004527117125689983,
0.020097773522138596,
-0.005143414717167616,
0.0020220684818923473,
0.0010670068440958858,
-0.006615381687879562,
0.003978095017373562,
0.02763625979423523,
-0.00022503279615193605,
0.0029195891693234444,
0.006548555102199316,
-0.004579303320497274,
-0.007336021866649389,
0.01740979216992855,
-0.02594631165266037,
-0.03567009046673775,
0.0003776676021516323,
0.008683635853230953,
0.02986045926809311,
0.01893036626279354,
-0.007750622928142548,
-0.005470644682645798,
-0.010124947875738144,
0.01150426547974348,
0.0008072007331065834,
0.01836971566081047,
-0.0015690880827605724,
-0.0010709598427638412,
-0.005846172571182251,
0.016156140714883804,
0.020774172618985176,
0.005432787351310253,
-0.019164176657795906,
-0.024211864918470383,
0.004690142814069986,
-0.013469018042087555,
0.021018151193857193,
0.03815107047557831,
-0.01268610917031765,
-0.017239326611161232,
0.013581253588199615,
0.02864101156592369,
-0.01032368652522564,
0.04233220964670181,
0.011422942392528057,
0.008076226338744164,
0.026598729193210602,
0.00704355351626873,
0.0063665579073131084,
-0.0014629538636654615,
-0.013583664782345295,
0.009213542565703392,
-0.00421336991712451,
0.02958543412387371,
0.006887505296617746,
0.013031420297920704,
-0.0025023221969604492,
-0.01023392379283905,
-0.022324254736304283,
0.00750629510730505,
-0.0009809399489313364,
0.06683973968029022,
0.0231560617685318,
0.008446060121059418,
-0.013985635712742805,
0.04662611335515976,
-0.006480306386947632,
-0.011072307825088501,
0.011868854984641075,
-0.008831232786178589,
-0.008642539381980896,
0.0012473859824240208,
0.003417807165533304,
-0.02503010630607605,
-0.028137022629380226,
-0.018042534589767456,
0.007120087742805481,
0.0027936643455177546,
0.014434337615966797,
0.01043657772243023,
-0.020517056807875633,
0.002399608725681901,
-0.03228346258401871,
-0.01169136818498373,
0.02434758096933365,
0.004073278978466988,
-0.007843992672860622,
0.0016779184807091951,
-0.004911552183330059,
0.0013771377271041274,
0.008161121048033237,
-0.022531747817993164,
0.01149290706962347,
-0.03344638645648956,
0.004103157669305801,
-0.006554086692631245,
-0.007721537724137306,
-0.018276087939739227,
0.012512903660535812,
0.008473517373204231,
0.0035531804896891117,
-0.009954138658940792,
0.00645062793046236,
0.016580022871494293,
-0.04225986450910568,
0.01265268586575985,
0.009541966021060944,
0.00420831423252821,
-0.006972854025661945,
0.008907444775104523,
-0.0173164252191782,
0.005373823922127485,
0.012183589860796928,
-0.009641163051128387,
-0.009161796420812607,
0.007374003529548645,
0.01853696070611477,
-0.009715636260807514,
0.009803777560591698,
0.003431812161579728,
0.021524939686059952,
-0.008375566452741623,
-0.019007524475455284,
0.006407547276467085,
-0.03993980586528778,
0.0053200488910079,
0.017258264124393463,
0.006234911270439625,
0.014021258801221848,
-0.01843637228012085,
-0.009521303698420525,
-0.024512331932783127,
0.005746449343860149,
-0.018651559948921204,
0.007207595743238926,
-0.01551830768585205,
0.032646194100379944,
-0.012215240858495235,
0.01910001039505005,
-0.016618283465504646,
0.022722788155078888,
-0.033056747168302536,
0.015755342319607735,
0.006820274982601404,
0.013851630501449108,
-0.00920911505818367,
-0.01939060166478157,
0.009331757202744484,
-0.007305969018489122,
0.010734965093433857,
0.007076537702232599,
0.006894729565829039,
0.008793373592197895,
-0.016525041311979294,
-0.0028132577426731586,
-0.08044032752513885,
-0.01620432920753956,
-0.007869014516472816,
-0.030369389802217484,
0.00915973074734211,
-0.0017255027778446674,
-0.011972308158874512,
-0.005877678282558918,
-0.003899662522599101,
0.01895083859562874,
0.02883226051926613,
-0.0023857099004089832,
-0.010033353231847286,
-0.02400093339383602,
-0.03507150709629059,
-0.00505690136924386,
0.008586183190345764,
0.026073075830936432,
-0.029825054109096527,
0.015555261634290218,
0.00745815085247159,
-0.024387303739786148,
0.00949514377862215,
0.02425907552242279,
-0.0018904106691479683,
0.018085993826389313,
0.019588220864534378,
0.012761542573571205,
-0.010208932682871819,
0.011432494968175888,
0.0031276734080165625,
-0.04487694054841995,
0.009043363854289055,
-0.012569472193717957,
0.016685429960489273,
-0.0022968901321291924,
-0.019901499152183533,
-0.03292194753885269,
-0.01241820864379406,
-0.004388082306832075,
0.0068794917315244675,
0.006090664304792881,
0.012995745986700058,
0.005327584687620401,
0.011525053530931473,
-0.013997821137309074,
0.003034676890820265,
0.007834276184439659,
0.018069002777338028,
0.01103255245834589,
-0.009797364473342896,
0.006690387614071369,
0.012172224931418896,
0.017019037157297134,
-0.000543608155567199,
0.009001707658171654,
-0.020520659163594246,
-0.015034204348921776,
-0.009643377736210823,
-0.015453258529305458,
-0.015523988753557205,
0.0038094171322882175,
-0.00471227103844285,
0.017053663730621338,
-0.02437996305525303,
0.025734424591064453,
0.015587233006954193,
0.009411793202161789,
-0.032990314066410065,
0.0027256510220468044,
-0.01996976137161255,
-0.0005443841218948364,
0.005874864757061005,
-0.013162124902009964,
-0.00028546713292598724,
-0.016419144347310066,
-0.015190080739557743,
-0.0007909545674920082,
0.015473964624106884,
-0.0012871213257312775,
-0.018119167536497116,
0.006486254744231701,
0.003399417269974947,
0.015544028952717781,
-0.026546282693743706,
0.03555324301123619,
0.006123681087046862,
0.014748215675354004,
0.010833173990249634,
-0.01778608188033104,
0.03690854460000992,
0.03279350325465202,
0.0009955907007679343,
0.01224585622549057,
-0.0063947350718081,
-0.051275771111249924,
0.027954459190368652,
0.004005673341453075,
0.0022894772700965405,
0.008774086833000183,
-0.007418556604534388,
-0.012554166838526726,
0.0028815725818276405,
-0.012155422940850258,
-0.017887568101286888,
0.017177430912852287,
-0.01556657999753952,
-0.009857786819338799,
0.006615094840526581,
0.0002029180177487433,
0.009731325320899487,
-0.0009610119741410017,
-0.010889082215726376,
-0.0020414062310010195,
0.010303506627678871,
0.01433649379760027,
0.018696915358304977,
0.014135127887129784,
0.07246798276901245,
-0.0003672637976706028,
0.009944254532456398,
-0.024041101336479187,
-0.007591480854898691,
-0.01994340494275093,
0.0039115650579333305,
0.001130011398345232,
-0.018919114023447037,
-0.007207391783595085,
0.010925211012363434,
-0.011225052177906036,
-0.0009262399980798364,
0.007437370717525482,
-0.019522644579410553,
0.00047795800492167473,
0.007964389398694038,
-0.0007558809593319893,
0.013654261827468872,
-0.0029380708001554012,
-0.039495691657066345,
0.013468141667544842,
-0.020820988342165947,
-0.0123842041939497,
0.0023427288979291916,
-0.0036983841564506292,
0.00925528071820736,
-0.01293490082025528,
-0.01091555505990982,
0.014179803431034088,
0.0002128554042428732,
-0.020493987947702408,
-0.005444779060781002,
-0.006324160844087601,
0.011155728250741959,
-0.0023231778759509325,
0.005703621543943882,
0.015568643808364868,
0.0196289774030447,
0.007873713970184326,
-0.015130477026104927,
-0.012384094297885895,
0.011671770364046097,
0.008842570707201958,
-0.012648987583816051,
-0.018584169447422028,
0.014255719259381294,
-0.006026361603289843,
-0.01710367202758789,
0.02093873918056488,
0.015774905681610107,
0.0017302001360803843,
0.016203930601477623,
0.0034249648451805115,
0.009023712016642094,
-0.005768113769590855,
0.0014290200779214501,
-0.011543132364749908,
0.012975577265024185,
0.009818028658628464,
0.00460713030770421,
-0.0318167470395565,
-0.001967318821698427,
-0.012058721855282784,
-0.011905915103852749,
-0.02303214743733406,
-0.011286702007055283,
-0.006216845009475946,
0.0068300580605864525,
-0.013593584299087524,
0.019775424152612686,
-0.007831019349396229,
-0.004011939279735088,
0.009529552422463894,
-0.0033949771896004677,
-0.003289945423603058,
-0.0163005068898201,
-0.017619211226701736,
0.017579764127731323,
-0.0028232033364474773,
0.007048499304801226,
-0.0025141537189483643,
-0.01589144393801689,
0.007370851002633572,
0.013126698322594166,
-0.01369501557201147,
0.00831579603254795,
-0.07434354722499847,
-0.030566081404685974,
0.00424082949757576,
-0.012508763000369072,
-0.0018001468852162361,
0.016922147944569588,
-0.011221013031899929,
-0.011199003085494041,
-0.0037118024192750454,
-0.010680295526981354,
0.008371441625058651,
-0.020375242456793785,
-0.02340816892683506,
-0.002574401907622814,
0.011598316952586174,
-0.006234948057681322,
-0.01222352497279644,
0.013362596742808819,
0.007102020550519228,
0.0313689224421978,
0.020061928778886795,
0.01457362249493599,
-0.012758929282426834,
-0.017127087339758873,
-0.012526354752480984,
-0.08153766393661499,
0.0283464677631855,
-0.008701575919985771,
-0.003581564873456955,
0.004108527675271034,
-0.0167236328125,
0.0014615020481869578,
-0.004546079318970442,
0.021148819476366043,
-0.012946241535246372,
0.014005724340677261,
0.00280457129701972,
-0.023722117766737938,
-0.021496210247278214,
0.031104503199458122,
-0.004986624699085951,
0.025884853675961494,
-0.013153580948710442,
-0.009315557777881622,
0.037481918931007385,
-0.005376943852752447,
0.04285183548927307,
-0.004979463294148445,
0.009946005418896675,
-0.013665569014847279,
-0.023000188171863556,
-0.024501409381628036,
0.0073177628219127655,
0.009614027105271816,
0.018164699897170067,
0.01001171674579382,
0.014827622100710869,
-0.0034389086067676544,
-0.03979596495628357,
-0.0011911315377801657,
-0.011710461229085922,
0.01404515653848648,
-0.0025556881446391344,
0.0193406380712986,
-0.012886947020888329,
-0.013849443756043911,
-0.014898061752319336,
-0.014490906149148941,
-0.01776905730366707,
0.00031759333796799183,
-0.03887471556663513,
0.0073397234082221985,
-0.0016230650944635272,
0.01493051927536726,
-0.007153369951993227,
0.009191839955747128,
-0.02108677849173546,
0.010491660796105862,
-0.027402309700846672,
0.00022852327674627304,
-0.016680561006069183,
-0.008254286833107471,
-0.005589555017650127,
0.034192122519016266,
0.0021810790058225393,
0.00031893502455204725,
-0.002299213781952858,
0.008870992809534073,
0.07193321734666824,
-0.029901044443249702,
0.018444642424583435,
0.020723868161439896,
0.004649120848625898,
0.00043863290920853615,
-0.04776845499873161,
-0.022444356232881546,
-0.015524594113230705,
-0.02397874742746353,
-0.013736195862293243,
0.0011009551817551255,
-0.002255241386592388,
0.01091217715293169,
0.018661055713891983,
0.013941396027803421,
-0.014630256220698357,
0.022166702896356583,
0.011797881685197353,
-0.005610273219645023,
0.0094182463362813,
-0.016591541469097137,
-0.0022117742337286472,
-0.02051152102649212,
0.027507349848747253,
0.008392108604311943,
0.024151086807250977,
-0.007928237318992615,
-0.014227116480469704,
0.008381860330700874,
0.00272159930318594,
-0.022863954305648804,
0.01058582216501236,
-0.04070192947983742,
0.02500438131392002,
0.01982496865093708,
0.009227770380675793,
0.005047168582677841,
0.0056905243545770645,
-0.012825462967157364,
0.013532808050513268,
-0.013164284639060497,
-0.0031125396490097046,
-0.003242746228352189,
0.02875133976340294,
-0.014524653553962708,
0.007739780005067587,
0.01861468330025673,
-0.0035222661681473255,
0.017712611705064774,
-0.008671733550727367,
-0.0050725131295621395,
-0.014078924432396889,
0.007838146761059761,
-0.02184755727648735,
-0.01477298978716135,
-0.006648174487054348,
0.01716284453868866,
0.019118769094347954,
0.008418569341301918,
-0.008753175847232342,
-0.020187269896268845,
-0.004934381693601608,
-0.01034142542630434,
0.002689491491764784,
-0.020146749913692474,
0.0009420588612556458,
-0.005650705192238092,
-0.007300124038010836,
0.014636056497693062,
-0.004697700496762991,
0.014259190298616886,
0.009192515164613724,
0.014352835714817047,
0.013734331354498863,
0.018140539526939392,
0.04451543837785721,
0.019236180931329727,
0.00877918116748333,
0.005430776625871658,
-0.007535289973020554,
0.005891561508178711,
0.04676077142357826,
0.0035709075164049864,
-0.01982354000210762,
0.019218891859054565,
-0.009522847831249237,
0.025547802448272705,
-0.01165023073554039,
-0.00868292897939682,
-0.010461977683007717,
0.014930970966815948,
0.014839316718280315,
-0.019605083391070366,
0.007006991654634476,
0.03349857032299042,
-0.02426341362297535,
-0.0004274906241334975,
-0.003753002267330885,
-0.024394461885094643,
0.016341716051101685,
-0.00890220608562231,
0.005545156542211771,
0.02751661278307438,
0.017747387290000916,
-0.0020412285812199116,
-0.007132569327950478,
0.01970011740922928,
-0.001438165083527565,
0.018909882754087448,
0.0160804633051157,
0.01760122738778591,
0.0002636718563735485,
-0.006174327805638313,
0.0051010423339903355,
0.01239294558763504,
-0.0008292623097077012,
-0.003804062958806753,
0.0032595042139291763,
-0.01338322926312685,
-0.01746886968612671,
0.005462381988763809,
0.015509191900491714,
0.026350928470492363,
-0.010107152163982391,
-0.023058190941810608,
-0.0037451647222042084,
0.0036661606281995773,
0.018487151712179184,
0.020286936312913895,
0.016652997583150864,
0.004086320288479328,
0.002681595738977194,
0.012832933105528355,
-0.02201729454100132,
0.003750207368284464,
-0.0033512874506413937,
-0.00168541818857193,
-0.005416183732450008,
-0.01715291105210781,
0.010753794573247433,
-0.02578221634030342,
0.007368311285972595,
-0.002719318261370063,
0.0072286962531507015,
0.008271941915154457,
0.02416304126381874,
0.030940677970647812,
0.0027305774856358767,
0.00834670476615429,
-0.01609237864613533,
0.002083901781588793,
0.021831145510077477,
-0.006369486451148987,
0.013337445445358753,
0.014387549832463264,
0.016582924872636795,
-0.015821250155568123,
-0.017308251932263374,
0.01587560959160328,
0.007935947738587856,
0.01359835546463728,
0.002040924970060587,
0.0055466596968472,
-0.0018435721285641193,
0.010360396467149258,
0.010589743964374065,
0.012387963943183422,
-0.007246246095746756,
0.034005701541900635,
0.011459390632808208,
-0.023325707763433456,
-0.005880972370505333,
0.00538769643753767,
-0.013079440221190453,
-0.013659248128533363,
0.0119706429541111,
0.013896767050027847,
-0.034902580082416534,
-0.006461313460022211,
0.0037098240572959185,
-0.0014851053711026907,
0.013215425424277782,
-0.009726392105221748,
-0.0003949444508180022,
0.0069717648439109325,
0.00003239436773583293,
0.022152336314320564,
0.010854302905499935,
-0.004531067796051502,
-0.0228100698441267,
0.015046984888613224,
-0.0006129908142611384,
0.0009886911138892174,
-0.0041646515019237995,
0.0037312423810362816,
0.003424879629164934,
-0.022469859570264816,
0.005909429397433996,
0.0005257977172732353,
0.023097366094589233,
0.011109180748462677
] | [
0.10819944739341736,
-0.11147857457399368,
0.14299815893173218,
-0.12355705350637436,
0.11220195144414902,
0.6287877559661865,
0.2725972831249237,
-0.42460522055625916,
-0.16145087778568268,
-0.31752869486808777,
0.19230814278125763,
0.5581233501434326,
-0.22498640418052673,
0.47169068455696106,
-0.06359979510307312,
0.6204551458358765,
0.3485781252384186,
0.5432100892066956,
-0.36029165983200073,
-0.34969833493232727,
-0.46364209055900574,
-0.06741805374622345,
0.25307613611221313,
-0.08308213204145432,
-0.1813107281923294,
-0.12273237109184265,
0.4302680194377899,
0.011632188223302364,
0.11593630164861679,
-0.17952969670295715,
-0.15557342767715454,
0.47662055492401123,
-0.25869667530059814,
-0.13850346207618713,
0.18376153707504272,
-0.4747878611087799,
-0.12291464954614639,
-0.08821150660514832,
0.4448776841163635,
-0.21594557166099548,
-0.08013544976711273,
-0.4082045555114746,
0.014917698688805103,
0.3259130120277405,
-0.49079442024230957,
-0.4894864857196808,
-1.4775958061218262,
0.30595022439956665,
-0.02628113143146038,
0.1724453717470169,
0.036472782492637634,
0.20875805616378784,
0.13427004218101501,
0.5320278406143188,
-0.3405863344669342,
0.34370213747024536,
-0.38475266098976135,
-0.060071878135204315,
0.2559664249420166,
-0.49466243386268616,
0.47523099184036255,
-0.5357430577278137,
0.12767896056175232,
0.4813695549964905,
0.0670027881860733,
0.3599105775356293,
0.4559783637523651,
0.20990289747714996,
-0.04980437457561493,
-0.22758518159389496,
0.0005812110030092299,
-0.6296646595001221,
-0.3022186756134033,
-0.08431634306907654,
-0.21153070032596588,
-0.13574343919754028,
-0.27389049530029297,
-0.2422516644001007,
0.4636060893535614,
-0.08147651702165604,
-0.21337208151817322,
0.034428004175424576,
0.3596768379211426,
-0.6973310708999634,
0.4666573107242584,
0.1662624627351761,
0.41828155517578125,
0.5612634420394897,
-0.6171374917030334,
0.21240511536598206,
-0.316027969121933,
-0.2501577138900757,
0.25829410552978516,
0.043486494570970535,
0.046928245574235916,
0.6673805117607117,
0.03915451839566231,
-0.061803508549928665,
0.06579941511154175,
0.09890421479940414,
-0.016329048201441765,
-0.24869513511657715,
-0.14616507291793823,
-0.602902889251709,
-0.6084463596343994,
-0.40051308274269104,
-0.06979251652956009,
-0.661756157875061,
-0.046014703810214996,
-0.03421828895807266,
-0.6417614817619324,
0.08290885388851166,
0.2621564269065857,
-0.12415928393602371,
-0.41239291429519653,
0.14017364382743835,
0.012584807351231575,
-0.44864562153816223,
-0.1391497105360031,
0.27159643173217773,
-0.3078414499759674,
0.38116830587387085,
0.019335968419909477,
0.26329076290130615,
0.4316388964653015,
0.25961410999298096,
0.8895601630210876,
0.38983607292175293,
-0.2921169400215149,
0.22923965752124786,
0.29311010241508484,
0.6128841638565063,
-0.08254557102918625,
-0.24924081563949585,
0.09667457640171051,
-0.19228865206241608,
-0.41180065274238586,
-0.09266361594200134,
-0.10012438893318176,
-0.09848693758249283,
-0.2827863097190857,
-0.6460155844688416,
0.0097460662946105,
0.008419850841164589,
0.16074500977993011,
-0.4252322316169739,
-0.39086756110191345,
-0.24342168867588043,
0.24036836624145508,
-0.0641513392329216,
0.40250590443611145,
0.19767555594444275,
-0.4858839809894562,
-0.5035123229026794,
-0.04065015912055969,
0.012599037028849125,
-0.09139615297317505,
-0.06999284774065018,
0.014671565033495426,
0.28177890181541443,
0.4504234492778778,
0.5394549369812012,
-0.4532184898853302,
-0.35647740960121155,
-0.10045531392097473,
-0.3425421714782715,
0.6746129989624023,
0.46608126163482666,
-0.1432344615459442,
0.1680239737033844,
-0.28974491357803345,
-0.23459456861019135,
0.033332061022520065,
0.07801011949777603,
-0.5613753199577332,
0.46127358078956604,
0.694232702255249,
0.19153743982315063,
0.4248464107513428,
-0.07040388882160187,
-0.397604763507843,
0.017775868996977806,
-0.02933908998966217,
-0.19562329351902008,
0.3809603750705719,
-0.6268371343612671,
0.28412702679634094,
-0.020520927384495735,
0.14034728705883026,
0.09111183881759644,
-0.30674323439598083,
-0.41973555088043213,
0.5639201402664185,
-0.8793045878410339,
1.198866367340088,
-0.43843746185302734,
-0.027237236499786377,
0.9640364646911621,
-0.21995007991790771,
-0.44464194774627686,
-0.18756718933582306,
0.3797256052494049,
0.4127078354358673,
-0.015665197744965553,
-0.8564419150352478,
-0.11813603341579437,
-0.05334687605500221,
-0.10304359346628189,
-0.34694725275039673,
0.03692677989602089,
0.496515154838562,
0.17250442504882812,
0.005680290050804615,
-0.7909127473831177,
0.21120037138462067,
0.06816975027322769,
0.14764229953289032,
0.21053309738636017,
0.2272254377603531,
0.21927672624588013,
0.8365476727485657,
-0.6227778792381287,
0.3551901578903198,
0.3559446930885315,
0.26972460746765137,
0.4702933728694916,
0.9084364771842957,
0.2638196647167206,
0.7959522008895874,
-0.09723180532455444,
0.20768636465072632,
0.09892313927412033,
0.4564879238605499,
0.01542756613343954,
-0.3762117326259613,
0.22461548447608948,
-0.10623738169670105,
-0.13937070965766907,
-0.18417657911777496,
0.02255864068865776,
0.37130677700042725,
0.6658897995948792,
-0.2018706053495407,
0.16105656325817108,
0.25470060110092163,
-0.16974718868732452,
-0.44681036472320557,
-0.24452736973762512,
-0.5678858160972595,
0.15393808484077454,
-0.3428162634372711,
0.5110857486724854,
0.053690142929553986,
-0.09557930380105972,
0.3674272894859314,
0.08269015699625015,
0.16503623127937317,
0.10600177198648453,
0.2373097836971283,
-0.027971608564257622,
-0.08681733906269073,
-0.3681047856807709,
0.05295532941818237,
0.07149498909711838,
-0.15048599243164062,
-0.22530218958854675,
-1.1522204875946045,
-0.8040977716445923,
0.2557204067707062,
0.9585809707641602,
0.11706200242042542,
0.5360762476921082,
-0.44278913736343384,
0.19425034523010254,
-0.08187084645032883,
-0.8253964781761169,
0.4086790978908539,
0.5876739621162415,
-0.647781252861023,
-0.08740183711051941,
0.06795692443847656,
-0.02381679229438305,
0.4794488251209259,
-0.5360412001609802,
-0.09176567941904068,
0.05536077544093132,
0.028297945857048035,
-0.0762406513094902,
-0.16136159002780914,
-0.2040964812040329,
-0.6785835027694702,
0.50682133436203,
0.030622508376836777,
-0.6054744720458984,
0.19951875507831573,
0.18029965460300446,
-0.0313962884247303,
0.14109843969345093,
0.5411068797111511,
-0.14288154244422913,
-0.2785142660140991,
0.08239682763814926,
0.002879481064155698,
-0.028878776356577873,
0.02940734103322029,
0.02739267796278,
0.2724262475967407,
0.48558613657951355,
-6.180706024169922,
0.08580344915390015,
-0.6192035675048828,
-0.04337053373456001,
-0.3890773355960846,
0.09184456616640091,
0.9197215437889099,
-0.11558254063129425,
0.1267455667257309,
-0.2668639123439789,
0.2674647867679596,
0.20113468170166016,
0.1203741729259491,
0.5286256670951843,
0.15591785311698914,
0.026316620409488678,
0.24858568608760834,
0.5619356632232666,
0.22894513607025146,
0.02197139337658882,
0.3683769702911377,
-0.019360151141881943,
-0.2589291036128998,
0.4597669839859009,
0.33228230476379395,
0.27954763174057007,
-0.8603261709213257,
0.22250017523765564,
-0.31436461210250854,
-0.1971379816532135,
0.13901710510253906,
-0.4740664064884186,
-0.1529027819633484,
-0.06561755388975143,
0.4097743034362793,
0.2727276086807251,
0.0542651042342186,
-0.13716557621955872,
0.26076632738113403,
-0.06648177653551102,
0.031134964898228645,
0.5878505110740662,
0.03028378263115883,
-0.2052668184041977,
0.11694727838039398,
-0.17295359075069427,
-0.04582289606332779,
0.291104257106781,
-0.08221721649169922,
0.6430391073226929,
-0.5871338844299316,
-0.010588164441287518,
0.21663504838943481,
0.3087560832500458,
0.17474256455898285,
-0.322513222694397,
-0.35537177324295044,
0.3841387629508972,
0.3032633662223816,
0.019098808988928795,
0.3550328314304352,
0.010281293652951717,
0.35212284326553345,
-0.6252482533454895,
-0.6092369556427002,
0.073746457695961,
-0.5219466686248779,
-0.6186434030532837,
-0.05070272460579872,
0.24825747311115265,
-0.4103679358959198,
-0.1294439733028412,
0.22761620581150055,
-0.8205105662345886,
0.08709082007408142,
-0.6621426343917847,
0.04225816950201988,
0.6160522699356079,
-0.2918242812156677,
-0.11961020529270172,
-0.1663571149110794,
-0.6390735507011414,
-0.36986175179481506,
0.3392193913459778,
0.3573592007160187,
-0.31407737731933594,
-0.07226759195327759,
-0.32029372453689575,
-0.041490256786346436,
0.22567209601402283,
0.4337919354438782,
-0.494743674993515,
0.2552502453327179,
0.06960304081439972,
0.3300595283508301,
0.488430917263031,
0.22117206454277039,
0.1516624391078949,
0.3332456052303314,
0.04996296390891075,
0.6068079471588135,
-0.10872199386358261,
-0.22163620591163635,
-0.809956431388855,
-0.12456746399402618,
0.1545783430337906,
-0.15425162017345428,
0.11123840510845184,
0.6230078339576721,
-0.5046463012695312,
-0.08683310449123383,
-0.20399756729602814,
-0.15519392490386963,
-0.2117147147655487,
0.4168756902217865,
-0.1924138218164444,
-0.02537943609058857,
0.35930418968200684,
0.6015689373016357,
0.18887324631214142,
0.2360421121120453,
0.0733260065317154,
-0.3569774627685547,
-0.3310622274875641,
0.4846220910549164,
-0.10804292559623718,
0.16982600092887878,
0.44082993268966675,
-0.639066219329834,
0.007557482458651066,
0.26813510060310364,
0.6337445974349976,
-0.14918996393680573,
0.008465172722935677,
0.5339972972869873,
-0.14524145424365997,
-0.15137740969657898,
-0.006369649898260832,
0.23863324522972107,
-0.2125951200723648,
0.06830982863903046,
0.09572504460811615,
-0.5592127442359924,
-0.003958145156502724,
-0.1278090626001358,
0.20557111501693726,
0.08267136663198471,
-0.4861566722393036,
-0.1654125452041626,
-0.31810280680656433,
0.4028678238391876,
-0.06781189143657684,
0.8336223363876343,
0.017794128507375717,
-0.553400456905365,
-0.10134047269821167,
0.45361483097076416,
0.21273186802864075,
-0.6072031855583191,
-0.32293012738227844,
0.39497819542884827,
-0.2957455515861511,
-0.9125272631645203,
-0.10550116002559662,
0.27592483162879944,
-0.1305893063545227,
-0.197087362408638,
-0.30679231882095337,
0.1448817253112793,
0.6314835548400879,
-0.17102527618408203,
-0.3134556710720062,
0.017875513061881065,
-0.15864212810993195,
-0.00370211829431355,
-0.0720214992761612,
-0.22515203058719635,
0.21487386524677277,
-0.2340722382068634,
-0.13124972581863403,
0.26283150911331177,
-0.3874811828136444,
-0.25638696551322937,
0.38616883754730225,
0.39519768953323364,
-0.0031338240951299667,
0.044480811804533005,
0.2866058945655823,
-0.49071934819221497,
-0.26765134930610657,
0.062108393758535385,
-0.05484047904610634,
0.5479146838188171,
-0.33001095056533813,
-0.28618907928466797,
-0.36567893624305725,
0.03822370991110802,
0.4533501863479614,
0.1633933186531067,
-0.03687185049057007,
0.015318093821406364,
0.5514087080955505,
-0.7707312703132629,
0.25621283054351807,
0.27878689765930176,
-0.1617136150598526,
-0.07504341751337051,
0.11865028738975525,
-0.11001208424568176,
-0.10292711853981018,
-0.8750509023666382,
-0.706957995891571,
-0.1772240847349167,
0.053052689880132675,
-0.1916934847831726,
0.25519585609436035,
-0.09063835442066193,
-0.7004168629646301,
-0.13557974994182587,
0.062380626797676086,
0.2806861698627472,
-0.0645623728632927,
-0.1578746885061264,
0.14871113002300262,
0.06970535218715668,
-0.12958982586860657,
0.3518766760826111,
-0.8578140139579773,
0.019595377147197723,
0.2485063523054123,
-0.09092248231172562,
-0.10013002902269363,
0.4051905572414398,
-0.2913322150707245,
-0.34105780720710754,
-0.5626246929168701,
-0.23280085623264313,
0.2207891345024109,
-0.1711709052324295,
0.0900837704539299,
-0.3588609993457794,
0.4934258460998535,
-0.12483926117420197,
-0.40641123056411743,
-0.006914279889315367,
-0.09057139605283737,
0.5255316495895386,
-0.7371460199356079,
-0.4027370512485504,
0.4571954011917114,
-0.10164409875869751,
-0.36723119020462036,
-0.3465481400489807,
-0.06222045421600342,
0.4203205406665802,
0.39671242237091064,
-0.2835628390312195,
-0.46222859621047974,
-0.06759589165449142,
0.3274937570095062,
0.14623431861400604,
-0.3404650390148163,
-0.39501622319221497,
-0.05740048363804817,
0.2932218015193939,
0.5262741446495056,
-0.2461264431476593,
-0.3518903851509094,
0.11082195490598679,
-0.26083192229270935,
0.2807008624076843,
0.020414559170603752,
0.34088948369026184,
0.5456308126449585,
-0.04791512340307236,
0.2760802209377289,
-0.2887437641620636,
0.5039171576499939,
-0.1851547807455063,
-0.20673570036888123,
0.042122405022382736,
-0.057426568120718,
0.6331480741500854,
-0.02456759288907051,
0.0016525856917724013,
-0.0023610221687704325,
0.058866724371910095,
-0.32705557346343994,
-0.21570542454719543,
0.21067950129508972,
-0.1664801985025406,
-0.02086810953915119,
-0.5747407674789429,
0.03866558521986008,
-0.002182529540732503,
0.2100849747657776,
0.4104653298854828,
0.4581443965435028,
0.10838282853364944,
-0.6357514262199402,
0.08540087938308716,
0.7264776825904846,
0.5750939249992371,
-0.551690399646759,
0.23328788578510284,
0.014834855683147907,
0.2496788501739502,
0.46554845571517944,
-0.4367121160030365,
0.16850890219211578,
0.3727726340293884,
0.04006727784872055,
0.4020250737667084,
0.4597073793411255,
-0.33020758628845215,
-0.0743078961968422,
0.003071832936257124,
0.08246186375617981,
0.37558960914611816,
0.09052573144435883,
-0.0797053799033165,
0.3728637099266052,
0.6320116519927979,
-0.4885704219341278,
-0.25546514987945557,
0.4567873477935791,
-0.3717682659626007,
0.24404717981815338,
0.060326624661684036,
0.5067428350448608,
0.7838484048843384,
0.11987336724996567,
-0.3633476495742798,
0.39228445291519165,
-0.12535132467746735,
0.11122625321149826,
0.33343029022216797,
-0.25781551003456116,
0.023884624242782593,
0.3502157926559448,
1.2107397317886353,
0.1206611767411232,
-0.5309771299362183,
0.060322582721710205,
-0.07971296459436417,
0.45355847477912903,
-0.16949203610420227,
-0.21496351063251495,
0.06529784947633743,
0.087514728307724,
0.3266870677471161,
-0.30452486872673035,
-0.3210296630859375,
-0.05279133468866348,
-0.10502321273088455,
-0.08386652171611786,
0.11223047226667404,
-0.42987769842147827,
0.10059706121683121,
0.2383555918931961,
0.19835340976715088,
0.20852482318878174,
0.0006107009248808026,
0.0004794250999111682,
-0.17736299335956573,
0.06797423958778381,
0.34398725628852844,
0.10313739627599716,
-0.1539202183485031,
-0.3717734217643738,
-0.08236858993768692,
-0.03336995095014572,
-0.2818480432033539,
0.17354042828083038,
0.43639010190963745,
-0.17908985912799835,
-0.05605079233646393,
0.3785437047481537,
-0.34691277146339417,
0.19730789959430695,
-0.6947051882743835,
0.0017074737697839737,
-0.010869897902011871,
-0.2359888106584549,
-0.26187223196029663,
-0.23118162155151367,
-0.13814999163150787,
-0.18835002183914185,
-0.14893101155757904,
0.0010961729567497969,
0.6298823356628418,
-0.68197101354599,
0.003609328530728817,
0.026438597589731216,
-0.3811992108821869,
-0.4019407331943512,
0.06465133279561996,
0.5510995388031006,
0.3248225450515747,
0.6063871383666992,
-0.3794611692428589,
0.16744452714920044,
-0.47596943378448486,
0.42030051350593567,
-0.23518520593643188,
0.1944599449634552,
-0.3958083391189575,
0.2568124234676361,
-0.15165948867797852,
-0.07370474189519882,
0.8368507027626038,
-0.16796353459358215,
-0.0824093148112297,
0.027769597247242928,
-0.3470962345600128,
0.45468035340309143,
0.382601261138916,
-0.2957269847393036,
0.15578144788742065,
-0.4071807861328125,
-0.5031288862228394,
-0.6953856348991394,
0.4703792333602905,
0.009785108268260956,
-0.14940273761749268,
0.1883101761341095,
0.46420958638191223,
0.1696472316980362,
-0.6167789101600647,
0.3543407917022705,
-0.3183954954147339,
0.0928986668586731,
-0.3417987823486328,
0.4140331447124481,
-0.8445575833320618,
-0.25243324041366577,
0.35823091864585876,
-0.1632496863603592,
0.021339107304811478,
-0.07226747274398804,
-0.36889973282814026,
-0.5096800923347473,
-0.12255151569843292,
0.6815482378005981,
0.04646861553192139,
0.3890380561351776,
0.08057087659835815,
-0.37369173765182495,
-0.7374388575553894,
0.1454864740371704,
-0.28216221928596497,
-0.10797818005084991,
-0.028387201949954033,
-0.13333360850811005,
-0.33081483840942383,
-0.2501241862773895,
0.1098102256655693,
-0.6790704727172852,
0.18320685625076294,
0.06049797311425209
] |
Recent events clearly illustrate a continued vulnerability of large populations to infectious diseases, which is related to our changing human-constructed and natural environments. A single person with multidrug-resistant tuberculosis in 2007 provided a wake-up call to the United States and global public health infrastructure, as the health professionals and the public realized that today’s ease of airline travel can potentially expose hundreds of persons to an untreatable disease associated with an infectious agent. Ease of travel, population increase, population displacement, pollution, agricultural activity, changing socioeconomic structures, and international conflicts worldwide have each contributed to infectious disease events. Today, however, nothing is larger in scale, has more potential for long-term effects, and is more uncertain than the effects of climate change on infectious disease outbreaks, epidemics, and pandemics. We discuss advances in our ability to predict these events and, in particular, the critical role that satellite imaging could play in mounting an effective response. | [
0.0003031922969967127,
0.018794182687997818,
-0.016189804300665855,
0.0019149616127833724,
0.021002672612667084,
0.006588771473616362,
0.007741129957139492,
0.02317383512854576,
-0.01233221311122179,
-0.043582089245319366,
0.0036482729483395815,
0.018039274960756302,
-0.004660909995436668,
0.011229378171265125,
-0.0003610593266785145,
-0.017006486654281616,
0.011776755563914776,
0.020148564130067825,
0.012272513471543789,
0.0015090962406247854,
-0.029837537556886673,
0.010805800557136536,
0.009832320734858513,
0.007621963508427143,
0.0039818971417844296,
0.008403249084949493,
-0.001633309293538332,
-0.0018592833075672388,
-0.03024669736623764,
-0.005339136812835932,
-0.003051141509786248,
0.02381564863026142,
0.00574748357757926,
0.0010970388539135456,
0.007744811475276947,
-0.008585462346673012,
0.005533368326723576,
0.012079176492989063,
-0.01157032698392868,
-0.0030971996020525694,
0.020466472953557968,
-0.012322237715125084,
0.0034972471185028553,
-0.011594295501708984,
-0.008124301210045815,
-0.010833912529051304,
-0.006691846065223217,
-0.00589369423687458,
-0.013464685529470444,
0.013550159521400928,
0.0023117302916944027,
-0.014287551864981651,
-0.006390199530869722,
0.03504463657736778,
-0.006068698130548,
-0.011068109422922134,
0.0199381485581398,
0.019394930452108383,
-0.025858182460069656,
0.018897520378232002,
-0.0013368080835789442,
0.00949777290225029,
0.0025468412786722183,
-0.01721121370792389,
0.030912593007087708,
-0.06704984605312347,
-0.007705952040851116,
0.0176209956407547,
-0.011788149364292622,
0.004871045239269733,
0.0009621955687180161,
0.007823883555829525,
0.005928088910877705,
-0.007970460690557957,
-0.024321749806404114,
-0.01870431937277317,
0.01187487505376339,
0.021263785660266876,
0.017740363255143166,
0.024774931371212006,
-0.021956101059913635,
-0.011341702193021774,
-0.010419406928122044,
0.02351735532283783,
-0.0008701467886567116,
0.004863784648478031,
-0.004084373824298382,
-0.00024406053125858307,
-0.014515012502670288,
0.0022981325164437294,
0.00453973701223731,
-0.0410849004983902,
-0.023062754422426224,
-0.015785839408636093,
-0.016497807577252388,
-0.00844187568873167,
-0.010957162827253342,
-0.004416140727698803,
0.0030112694948911667,
-0.005421149078756571,
0.00286713894456625,
0.004418279509991407,
0.01700291410088539,
0.015575897879898548,
0.04138196259737015,
0.005646023899316788,
-0.018619908019900322,
0.019557511433959007,
0.008503427729010582,
0.0066579170525074005,
-0.006412694696336985,
0.0037590879946947098,
-0.0004518120549619198,
0.024673236533999443,
-0.003055180422961712,
0.025630518794059753,
0.0072190240025520325,
-0.02592674270272255,
0.00949622131884098,
0.0019830367527902126,
0.002954246010631323,
-0.012547816149890423,
-0.00021327921422198415,
0.000009109266102313995,
-0.0016653466736897826,
0.0045062219724059105,
-0.007789311930537224,
-0.00006366265006363392,
0.0073515381664037704,
0.012125024572014809,
-0.0059755463153123856,
0.009296227246522903,
-0.010991904884576797,
-0.011257131583988667,
0.006146631203591824,
-0.003034980036318302,
-0.016014430671930313,
0.014703819528222084,
-0.0015906180487945676,
0.010441428050398827,
-0.01781897060573101,
0.007671552710235119,
-0.008041629567742348,
0.02002561278641224,
0.02368081547319889,
-0.000012489384971559048,
-0.017710277810692787,
0.010264065116643906,
0.021096760407090187,
0.008945298381149769,
0.017607446759939194,
-0.007941645570099354,
0.01170667540282011,
-0.011236026883125305,
-0.01079239696264267,
0.012019159272313118,
0.0023598663974553347,
-0.005791722796857357,
0.003663879819214344,
0.014803003519773483,
0.014454443007707596,
-0.002459583804011345,
0.00645974837243557,
0.008288131095468998,
0.0235265102237463,
-0.008834833279252052,
0.009154804050922394,
0.002949892543256283,
0.007253748364746571,
0.008833101950585842,
0.00004130473826080561,
0.003162024775519967,
-0.020885849371552467,
0.01203947328031063,
-0.00583844305947423,
0.003791439812630415,
0.019352221861481667,
0.007107231765985489,
0.002421943936496973,
0.06627710163593292,
0.00503011979162693,
-0.03292478248476982,
-0.004140128847211599,
0.02090608701109886,
0.011681588366627693,
-0.0035529821179807186,
0.04468867555260658,
-0.006181187927722931,
-0.01933254301548004,
-0.001802319660782814,
-0.0006440773140639067,
-0.008736814372241497,
-0.0030756869819015265,
-0.016402199864387512,
0.028913069516420364,
0.0033609806559979916,
-0.007467442657798529,
-0.0012051837984472513,
0.013629392720758915,
0.03014061041176319,
0.030379049479961395,
0.023944981396198273,
0.012468318454921246,
-0.0036458433605730534,
-0.022265490144491196,
0.013004140928387642,
0.024144573137164116,
0.0008744886144995689,
0.010879499837756157,
-0.015819722786545753,
0.011612329632043839,
-0.0048642223700881,
0.020583823323249817,
-0.022248368710279465,
-0.02145283669233322,
0.0020691596437245607,
-0.01994660682976246,
-0.010765012353658676,
-0.026512177661061287,
-0.01489164773374796,
-0.002367644803598523,
0.01435130275785923,
-0.0062478082254529,
-0.01365557499229908,
0.020134899765253067,
0.01885056123137474,
0.005064032040536404,
0.010458908975124359,
0.006773409433662891,
-0.014052196405827999,
-0.00225791591219604,
-0.00785617996007204,
-0.00546692032366991,
-0.0038112979382276535,
0.009908804669976234,
0.008055383339524269,
0.009697496891021729,
0.0005601582815870643,
0.01005836296826601,
-0.018967021256685257,
0.006046186201274395,
-0.006313079968094826,
0.01815875619649887,
-0.0002620605519041419,
0.0027744555845856667,
-0.004183068405836821,
0.013336493633687496,
-0.0048546879552304745,
0.0021622558124363422,
-0.003926459234207869,
0.005721558351069689,
-0.007716527208685875,
0.01331030111759901,
0.028499646112322807,
0.013359162025153637,
0.02148524671792984,
0.006995851173996925,
-0.015890182927250862,
0.027289874851703644,
0.00379653787240386,
0.010185565799474716,
0.007200681604444981,
0.007712116464972496,
-0.030416063964366913,
0.03709933161735535,
0.015748586505651474,
0.018119923770427704,
0.007490095682442188,
0.011561750434339046,
0.022770507261157036,
0.006663065403699875,
-0.003493725322186947,
0.011724201962351799,
-0.0821489542722702,
-0.00785057246685028,
0.00477965921163559,
-0.0017989242915064096,
0.013349862769246101,
-0.01337920781224966,
-0.0033542211167514324,
-0.004357656929641962,
-0.009901643730700016,
0.05459420010447502,
0.016658153384923935,
0.0013545688707381487,
-0.0036227856762707233,
-0.015295732766389847,
-0.008772926405072212,
-0.006967838853597641,
0.005407363176345825,
-0.01483489852398634,
-0.012989352457225323,
-0.023605627939105034,
-0.003864858765155077,
0.0028096658643335104,
0.031039513647556305,
-0.016082851216197014,
-0.014903677627444267,
0.013691769912838936,
0.025914322584867477,
0.0062491875141859055,
0.010804093442857265,
0.019739452749490738,
0.028884319588541985,
0.004015904385596514,
-0.0090809166431427,
-0.013695224188268185,
0.012660983949899673,
-0.019975963979959488,
-0.006112947128713131,
-0.01814778707921505,
-0.007997212000191212,
0.006541240960359573,
0.016062505543231964,
0.006672591902315617,
-0.003447754541411996,
0.006812450475990772,
0.015185065567493439,
-0.003295236499980092,
0.022590884938836098,
0.013107027858495712,
0.007688651327043772,
-0.00031703757122159004,
-0.011207633651793003,
-0.004094428848475218,
0.019106898456811905,
0.006275635212659836,
-0.004791419953107834,
-0.026520222425460815,
-0.00687555642798543,
-0.038919221609830856,
-0.010338256135582924,
-0.013348464854061604,
-0.0034801033325493336,
0.018822159618139267,
0.016089316457509995,
0.02129053883254528,
-0.013022543862462044,
-0.01586662232875824,
0.004254448227584362,
-0.000378571217879653,
-0.01952507719397545,
0.000562309636734426,
0.009547905065119267,
0.005851618945598602,
0.018935909494757652,
-0.007972260937094688,
0.006342801731079817,
-0.003999592270702124,
-0.0165395587682724,
0.0018174666911363602,
0.021000219509005547,
-0.005900489166378975,
-0.024591093882918358,
0.0035490337759256363,
0.014010999351739883,
0.016357535496354103,
-0.000513965729624033,
-0.019275058060884476,
0.011314797215163708,
0.023060310631990433,
0.011381430551409721,
-0.011690441519021988,
0.013097681105136871,
-0.017715632915496826,
-0.01801031082868576,
0.006607480347156525,
-0.0114347655326128,
-0.02969193458557129,
-0.01092855166643858,
-0.011877693235874176,
-0.022162923589348793,
0.008164076134562492,
0.011393427848815918,
-0.0013999583898112178,
0.0038754958659410477,
-0.009730938822031021,
-0.0115479351952672,
0.012876464985311031,
0.022447150200605392,
0.00045521650463342667,
-0.002317056292667985,
-0.011938773095607758,
0.011617684736847878,
0.017840944230556488,
0.0004740796284750104,
0.013340624049305916,
0.009477254003286362,
0.007093152031302452,
-0.00702621228992939,
-0.018699677661061287,
0.07238135486841202,
-0.014801381155848503,
0.004217549692839384,
-0.008862299844622612,
0.007828324101865292,
-0.03265875205397606,
0.017078496515750885,
0.004820425063371658,
0.022453811019659042,
-0.013410977087914944,
0.014248601160943508,
-0.015862947329878807,
-0.013976499438285828,
-0.014587733894586563,
0.004119472112506628,
-0.015769407153129578,
-0.001087523065507412,
-0.0023392396979033947,
-0.0005400181980803609,
-0.019467806443572044,
0.014352813363075256,
-0.025788746774196625,
0.002308824099600315,
0.02451447769999504,
-0.011537802405655384,
-0.0073523144237697124,
0.013086169958114624,
-0.007503911852836609,
-0.0012561308685690165,
0.0026358687318861485,
0.035186074674129486,
0.024220949038863182,
-0.0036278232000768185,
-0.0031045451760292053,
0.012279711663722992,
-0.005782757885754108,
0.002463010838255286,
0.011088954284787178,
-0.007645291276276112,
-0.0061563607305288315,
-0.013826378621160984,
-0.011319233104586601,
0.0032550510950386524,
0.005863996688276529,
-0.01615196466445923,
0.028429608792066574,
0.009774301201105118,
-0.004042049869894981,
-0.000666855601593852,
0.0072371456772089005,
-0.0018425554735586047,
0.020459238439798355,
0.010815529152750969,
0.001438760431483388,
0.010021060705184937,
0.007021727971732616,
-0.016336694359779358,
-0.00010775681585073471,
0.004403816536068916,
0.008044750429689884,
-0.0003925783094018698,
0.011808998882770538,
-0.017685137689113617,
-0.019898466765880585,
0.006317255552858114,
-0.010835664346814156,
0.0058525074273347855,
-0.005839724093675613,
-0.009328492917120457,
-0.01569000817835331,
-0.007401225157082081,
-0.02152504399418831,
-0.005957266315817833,
-0.020152267068624496,
-0.0203046053647995,
0.01609870046377182,
-0.03615439683198929,
0.01180591993033886,
0.016104718670248985,
-0.008329165168106556,
-0.009650714695453644,
-0.008376136422157288,
0.009200600907206535,
-0.02746708318591118,
-0.009333930909633636,
0.016039904206991196,
-0.012407430447638035,
-0.07527591288089752,
0.008559796027839184,
-0.0013153422623872757,
-0.009955479763448238,
-0.00719666900113225,
-0.004352661781013012,
-0.000648684217594564,
0.001356444787234068,
0.0023699672892689705,
-0.0016898575704544783,
-0.025896452367305756,
-0.003832772606983781,
-0.006489245221018791,
0.008736427873373032,
0.016096120700240135,
0.0174413975328207,
-0.0181264728307724,
-0.008307946845889091,
-0.019733130931854248,
0.009445544332265854,
-0.0016336455009877682,
-0.003621874377131462,
-0.012410546652972698,
-0.0030925138853490353,
-0.006009592674672604,
-0.0813504308462143,
-0.009129481390118599,
-0.006834544241428375,
-0.0008715633302927017,
-0.004694449715316296,
0.005251691211014986,
0.011926136910915375,
-0.022420428693294525,
-0.01660621538758278,
-0.015163226053118706,
-0.010045986622571945,
0.012655767612159252,
-0.024071723222732544,
-0.019030649214982986,
-0.007573065813630819,
-0.00550630921497941,
0.0070709167048335075,
-0.002394278533756733,
-0.00229811598546803,
-0.004650800488889217,
0.019607828930020332,
0.019704636186361313,
-0.006349095143377781,
0.0021755057387053967,
-0.013537697494029999,
-0.03947051614522934,
0.005454837344586849,
-0.0016187777509912848,
0.008473583497107029,
0.022509805858135223,
0.006084030959755182,
0.0007178615778684616,
0.0011948829051107168,
-0.003848704043775797,
0.018323348835110664,
-0.006311170756816864,
0.02431643009185791,
0.010060984641313553,
0.034312713891267776,
-0.006249419879168272,
-0.01187589019536972,
0.004184084013104439,
0.0001728534698486328,
0.007585437037050724,
0.022382425144314766,
-0.011333232745528221,
0.007745750248432159,
-0.009863346815109253,
0.017229760065674782,
0.00822385959327221,
0.0005602254532277584,
-0.024728428572416306,
-0.006309157703071833,
-0.003302625846117735,
0.011074546724557877,
0.0002663761842995882,
-0.01052502915263176,
0.0041913497261703014,
-0.010329002514481544,
0.01639017090201378,
0.01698262430727482,
0.008749114349484444,
0.010928301140666008,
0.071131631731987,
-0.04223477095365524,
-0.00023494905326515436,
-0.013191092759370804,
-0.011847425252199173,
-0.0005158415879122913,
-0.01305561326444149,
0.008955774828791618,
-0.028835054486989975,
-0.018949225544929504,
0.009655950590968132,
-0.004871849901974201,
-0.009338791482150555,
0.0038025910034775734,
0.02124202251434326,
0.00004188111051917076,
-0.02635117433965206,
-0.02710641548037529,
-0.005157517734915018,
-0.02746647596359253,
-0.03042154386639595,
-0.01079570222645998,
-0.00669464934617281,
0.008490568026900291,
0.01965896226465702,
0.005689325742423534,
-0.01907295174896717,
-0.007816458120942116,
-0.014899976551532745,
0.01676856353878975,
-0.024788519367575645,
0.0045560626313090324,
0.006723618600517511,
0.014223452657461166,
0.03309448063373566,
-0.014322571456432343,
-0.003236175514757633,
-0.00021368253510445356,
-0.008960453793406487,
0.016873348504304886,
0.00045978312846273184,
0.0022631273604929447,
0.0066899145022034645,
-0.012989815324544907,
0.01633545011281967,
-0.0184282585978508,
0.01961132325232029,
0.02233244478702545,
0.004815184511244297,
0.010857613757252693,
-0.021870505064725876,
0.005848403554409742,
0.007733696140348911,
0.01607362926006317,
-0.013723553158342838,
0.019356565549969673,
0.036578789353370667,
0.011077050119638443,
0.01820790022611618,
-0.018651433289051056,
0.010869026184082031,
-0.007511951960623264,
0.009185248985886574,
-0.015127530321478844,
-0.007462925277650356,
-0.009252862073481083,
-0.009994054213166237,
-0.022294646129012108,
0.0072430940344929695,
0.002655173884704709,
0.00937743205577135,
0.0010701108258217573,
0.007177677936851978,
-0.007622826844453812,
0.02153538167476654,
0.018228014931082726,
0.015737002715468407,
-0.003600836731493473,
0.009326191619038582,
-0.007838208228349686,
-0.013574814423918724,
-0.024425765499472618,
0.006422951351851225,
-0.0014828448183834553,
-0.03836581110954285,
0.004752285312861204,
0.007501666434109211,
0.016549337655305862,
-0.018490031361579895,
0.005170849151909351,
0.017220381647348404,
0.0010715334210544825,
-0.004743441939353943,
0.012214123271405697,
0.014329826459288597,
0.036370061337947845,
0.01892712712287903,
0.006597443018108606,
-0.004516132175922394,
0.0006897766143083572,
-0.008685578592121601,
-0.03503973037004471,
0.006896145176142454,
-0.0167384073138237,
-0.010706394910812378,
-0.008831042796373367,
0.002454708330333233,
0.004837073385715485,
-0.006852606311440468,
0.008624792098999023,
-0.013693821616470814,
0.0022206436842679977,
0.000005091540515422821,
0.0007134329061955214,
0.005451874807476997,
-0.012225472368299961,
-0.0071261487901210785,
0.008838538080453873,
-0.00377646554261446,
-0.012391887605190277,
-0.0014189084758982062,
-0.010943394154310226,
-0.01813022419810295,
0.0035619912669062614,
0.0015964650083333254,
0.012180034071207047,
-0.009147575125098228,
-0.020004428923130035,
-0.012915335595607758,
0.033871956169605255,
0.005031686741858721,
0.007780351676046848,
-0.013026073575019836,
0.005166726652532816,
0.011877201497554779,
0.019326267763972282,
-0.01246171910315752,
-0.00037782732397317886,
0.0027794204652309418,
-0.007202997803688049,
0.00264893751591444,
-0.016466543078422546,
0.0017832585144788027,
0.00002655060961842537,
0.008959216065704823,
0.03599898889660835,
0.015246633440256119,
0.02018849179148674,
0.024889497086405754,
0.0038871460128575563,
0.0026539682876318693,
-0.015393342822790146,
0.003786537330597639,
-0.0030226153321564198,
0.0019215388456359506,
0.01070564053952694,
0.0027601751498878,
-0.008575472049415112,
-0.005102106370031834,
-0.012341698631644249,
-0.012841135263442993,
0.010365404188632965,
-0.006805696524679661,
-0.006899399682879448,
0.003882609773427248,
-0.002477735048159957,
0.02035532146692276,
0.0005696439184248447,
-0.01014142856001854,
0.02184765413403511,
-0.030021607875823975,
0.007294867187738419,
-0.017704084515571594,
0.007073722779750824,
-0.0012912098318338394,
-0.013722099363803864,
-0.0059906658716499805,
0.0018873410299420357,
-0.013765680603682995,
0.014703420922160149,
-0.0009226389229297638,
0.0017805283423513174,
0.003396849147975445,
-0.008458560332655907,
-0.009465036913752556,
0.019533000886440277,
-0.011821042746305466,
-0.0006436106050387025,
0.011902456171810627,
-0.007222430780529976,
-0.008241443894803524,
-0.039105162024497986,
-0.009637688286602497,
-0.0030673639848828316,
-0.009067291393876076,
0.00554776843637228,
-0.003784115891903639,
0.0035464633256196976,
0.008532153442502022,
0.009741928428411484,
0.007352030836045742,
-0.005553160794079304
] | [
0.18385589122772217,
0.12284065783023834,
-0.05548747628927231,
-0.18386119604110718,
0.2543729245662689,
0.06753585487604141,
0.32206597924232483,
0.38966286182403564,
-0.40923434495925903,
-0.6300747990608215,
0.02661212719976902,
-0.19839580357074738,
-0.6229312419891357,
0.6623246073722839,
-0.12425471097230911,
0.09024188667535782,
0.15703073143959045,
-0.08718425780534744,
-0.1369858980178833,
-0.3080988824367523,
-0.6546218991279602,
-0.3564319610595703,
0.3078782558441162,
0.21152183413505554,
0.015250724740326405,
-0.6199156641960144,
-0.052765026688575745,
-0.28443989157676697,
-0.03605121746659279,
0.1602289378643036,
0.2348218411207199,
0.5234526991844177,
0.14002713561058044,
0.1407087743282318,
-0.11959713697433472,
0.03607780486345291,
-0.15549489855766296,
-0.33230432868003845,
-0.2559705674648285,
-0.06607706844806671,
-0.24935035407543182,
-0.1476343721151352,
0.17553500831127167,
0.5510468482971191,
0.061015624552965164,
-0.3029598891735077,
-1.220510482788086,
0.5855520367622375,
-0.194859117269516,
-0.060213860124349594,
-0.10510686784982681,
-0.09417843073606491,
0.48577189445495605,
0.17584677040576935,
-0.18504807353019714,
0.3349083364009857,
-0.32026639580726624,
-0.10004545748233795,
0.07548540085554123,
-0.4749695360660553,
0.5030514001846313,
-0.20646509528160095,
-0.10329333692789078,
-0.09537345916032791,
-0.6388406157493591,
0.25671088695526123,
0.5501717925071716,
0.3528658449649811,
0.09642402082681656,
-0.1497243493795395,
0.13964156806468964,
-0.34470972418785095,
-0.3085644245147705,
0.08447204530239105,
-0.3047737181186676,
-0.46377119421958923,
0.17049871385097504,
-0.23787131905555725,
0.19109898805618286,
-0.067919060587883,
-0.03485671430826187,
-0.12609519064426422,
0.2164202779531479,
-0.22125928103923798,
0.3955445885658264,
-0.007923433557152748,
0.1935131847858429,
0.5039082169532776,
-0.3100309669971466,
-0.12173859030008316,
0.017545970156788826,
-0.2680731415748596,
0.4353693723678589,
0.594058632850647,
-0.13578955829143524,
-0.04655249044299126,
0.4456333518028259,
-0.19551029801368713,
0.25689980387687683,
-0.27871304750442505,
-0.5524713397026062,
-0.22633790969848633,
0.36691972613334656,
0.08055701851844788,
0.24653546512126923,
-0.3121991753578186,
-0.040939394384622574,
-0.2638956606388092,
0.13903608918190002,
-0.2073201984167099,
-0.05825867876410484,
0.1142193004488945,
-0.49540361762046814,
-0.09503914415836334,
-0.3168361186981201,
0.5012621283531189,
0.21133433282375336,
-0.6287176609039307,
0.06025436893105507,
-0.5572734475135803,
-0.3255171477794647,
0.7380645871162415,
-0.3632434606552124,
-0.1271495670080185,
-0.3439478874206543,
0.10906927287578583,
0.6380445957183838,
-0.21258611977100372,
-0.1632792204618454,
0.4468619227409363,
-0.04220731556415558,
0.6680585741996765,
-0.4674838185310364,
-0.1955057978630066,
0.18268917500972748,
-0.008158226497471333,
-0.1995546519756317,
0.33010098338127136,
0.13123826682567596,
-0.2334650307893753,
-0.07364752888679504,
-0.7536022663116455,
-0.5373671054840088,
0.5107086300849915,
0.2522425353527069,
-0.12056183815002441,
-0.41009241342544556,
-0.02956456132233143,
0.07418864220380783,
-0.6430429220199585,
-0.17289048433303833,
-0.31034204363822937,
-0.3526354432106018,
0.5900871157646179,
0.34816303849220276,
0.37559381127357483,
-0.13668625056743622,
-0.5700733065605164,
0.3043898344039917,
0.0763973593711853,
0.5594693422317505,
0.5110422968864441,
0.01545870304107666,
-0.5034729838371277,
-0.006542982067912817,
-0.17458388209342957,
-0.14003218710422516,
0.32802489399909973,
0.1701238453388214,
-0.2363300770521164,
-0.5543746948242188,
0.05019114911556244,
-0.052963241934776306,
-0.6281959414482117,
-0.4083358645439148,
0.2814636826515198,
0.5323148369789124,
-0.040969885885715485,
0.03634277358651161,
0.3925017714500427,
-0.6704742312431335,
-0.16825076937675476,
-0.06767458468675613,
-0.19416554272174835,
0.2520390450954437,
-0.17624764144420624,
0.12100796401500702,
0.5688921809196472,
0.347853422164917,
0.16641031205654144,
-0.1764732003211975,
-0.5449472665786743,
0.37938448786735535,
-0.38272586464881897,
0.9855217933654785,
-0.20128263533115387,
0.41452381014823914,
1.4774963855743408,
0.1633121818304062,
0.013523240573704243,
-0.08320668339729309,
0.36286547780036926,
0.7170822024345398,
-0.32382896542549133,
-0.3123651444911957,
0.5272423028945923,
0.2365809679031372,
-0.021889252588152885,
-0.06357306987047195,
-0.23070447146892548,
0.5849542617797852,
0.16107100248336792,
-0.0887613520026207,
0.18622638285160065,
0.2730250060558319,
0.24727605283260345,
-0.23734642565250397,
0.1081327572464943,
-0.32991814613342285,
-0.32598429918289185,
0.09146717935800552,
-0.1927211731672287,
0.20659731328487396,
0.251651793718338,
0.4878588318824768,
0.5098888874053955,
0.2965811789035797,
-0.15015529096126556,
0.7475137710571289,
-0.5105408430099487,
0.1802130788564682,
-0.0023521017283201218,
0.2865390181541443,
-0.45233389735221863,
-0.27393823862075806,
0.2382272183895111,
0.09128385037183762,
-0.1046685054898262,
-0.2515055239200592,
0.039195459336042404,
0.34031662344932556,
-0.08563223481178284,
-0.4098226726055145,
0.6187976598739624,
-0.20569592714309692,
-0.6030862927436829,
-0.003098448971286416,
-0.043865401297807693,
-0.384705513715744,
-0.23548702895641327,
0.25239795446395874,
0.8717548847198486,
0.04110105708241463,
-0.11854767054319382,
0.3723066449165344,
0.0035040525253862143,
0.21472886204719543,
-0.015853311866521835,
0.5366946458816528,
-0.18510235846042633,
-0.0527518093585968,
0.138619065284729,
0.028770821169018745,
0.313970685005188,
-0.10488251596689224,
-0.4362175166606903,
-0.7524913549423218,
-0.5699875354766846,
0.42905253171920776,
0.42171892523765564,
0.6249907612800598,
0.06223759055137634,
-0.2863978445529938,
0.3415962755680084,
0.18707075715065002,
-0.29997435212135315,
0.2788757085800171,
0.6957784295082092,
-0.5724681615829468,
0.23592813313007355,
-0.08204825967550278,
0.6592217087745667,
0.5155907273292542,
-1.0632238388061523,
-0.061414096504449844,
-0.41674432158470154,
-0.028511187061667442,
-0.1439109444618225,
-0.5630910396575928,
0.29873934388160706,
-0.11932078003883362,
-0.22844275832176208,
0.009861752390861511,
-0.014245055615901947,
0.10323909670114517,
-0.038697436451911926,
0.13128602504730225,
0.10062657296657562,
0.3648693263530731,
0.08748450130224228,
-0.04287051782011986,
0.02041500248014927,
-0.39658501744270325,
-0.23969830572605133,
-0.059240955859422684,
0.023300493136048317,
-0.3957173824310303,
-0.14857199788093567,
-6.323235034942627,
0.22440855205059052,
0.20466116070747375,
-0.6506913304328918,
-0.42884361743927,
-0.08331045508384705,
0.8996001482009888,
0.22510142624378204,
0.1680249273777008,
0.170720174908638,
0.8167576193809509,
0.44516539573669434,
0.0883016511797905,
0.0492132194340229,
-0.5701856017112732,
0.2557137906551361,
0.20321466028690338,
0.040082648396492004,
0.10884272307157516,
0.2821076810359955,
0.2957797646522522,
-0.28069421648979187,
-0.3083673417568207,
0.38209855556488037,
0.0428018681704998,
0.14484292268753052,
-0.676357626914978,
0.21304653584957123,
-0.12373783439397812,
0.12633509933948517,
0.4668869972229004,
-0.44041335582733154,
0.13800139725208282,
0.06233280524611473,
-0.08665385097265244,
0.26647958159446716,
-0.37282535433769226,
-0.0739070475101471,
-0.20585106313228607,
-0.3539295196533203,
-0.323248028755188,
0.05713517218828201,
-0.33904704451560974,
-0.27975013852119446,
0.15257085859775543,
-0.06609473377466202,
-0.16413427889347076,
0.3885714113712311,
0.2017274796962738,
0.4092745780944824,
0.32030344009399414,
0.09384079277515411,
0.24455973505973816,
0.6142282485961914,
0.4988602101802826,
0.007597189862281084,
-0.3564775288105011,
-0.21869581937789917,
-0.19526362419128418,
-0.34936100244522095,
-0.02297903783619404,
0.18917186558246613,
0.18786963820457458,
-0.4302584230899811,
0.2331976294517517,
0.2276437133550644,
-0.47537702322006226,
-0.222163125872612,
-0.07140470296144485,
-0.19624733924865723,
-0.10761130601167679,
0.4059724509716034,
0.2634059190750122,
-0.5156307816505432,
0.03351932018995285,
-0.7458791136741638,
0.307464063167572,
0.16697777807712555,
0.27572134137153625,
-0.5556364059448242,
-0.48417484760284424,
-0.009026909247040749,
-0.27573105692863464,
-0.46444371342658997,
0.48421958088874817,
-0.45207884907722473,
0.07332867383956909,
-0.14619524776935577,
-0.015055598691105843,
-0.03997674584388733,
0.717586874961853,
-0.4400237500667572,
-0.13798832893371582,
0.4506775438785553,
0.45376724004745483,
0.7541139125823975,
-0.16089734435081482,
0.17269589006900787,
0.35808899998664856,
0.12896530330181122,
0.19848348200321198,
0.14076830446720123,
-0.33218932151794434,
-0.27066653966903687,
0.07531585544347763,
-0.19377508759498596,
0.05394596606492996,
0.23799781501293182,
0.51690274477005,
-0.5101842880249023,
0.09004655480384827,
0.1364467591047287,
-0.38984188437461853,
-0.46297621726989746,
0.3770281970500946,
-0.1348126232624054,
0.5116112232208252,
0.36709457635879517,
0.6310452818870544,
-0.07953570038080215,
0.4462658166885376,
0.038487184792757034,
-0.45171982049942017,
0.6666647791862488,
0.34484386444091797,
0.12290580570697784,
-0.3841090500354767,
0.3146170973777771,
-0.31951573491096497,
-0.04135385528206825,
0.3747312128543854,
0.2957117259502411,
0.27459344267845154,
0.1980629712343216,
0.30550891160964966,
-0.4016280770301819,
0.13197988271713257,
-0.2976056933403015,
-0.13057999312877655,
-0.35332080721855164,
-0.33333441615104675,
0.20068661868572235,
-0.4462774693965912,
-0.05636707693338394,
-0.05226515233516693,
0.2288406938314438,
-0.06476247310638428,
0.1813269555568695,
0.018208960071206093,
-0.0963960736989975,
-0.20514976978302002,
-0.06577969342470169,
-0.0586954690515995,
0.43962767720222473,
-0.7176750898361206,
0.1958564817905426,
1.1333309412002563,
-0.04067763313651085,
-0.5094302296638489,
-0.19601093232631683,
0.36176395416259766,
0.18332898616790771,
-0.7196837067604065,
0.045749567449092865,
-0.28846675157546997,
-0.0778910294175148,
0.269336998462677,
-0.4988301992416382,
0.13182365894317627,
0.013850666582584381,
0.1386416107416153,
-0.23915225267410278,
-0.6997768878936768,
0.12272734940052032,
0.07123960554599762,
0.05546201020479202,
-0.5862919688224792,
-0.02574402280151844,
0.1421230286359787,
0.2222491204738617,
0.10922305285930634,
-0.2926539480686188,
-0.5461474657058716,
0.4728127121925354,
0.4033617079257965,
0.12668299674987793,
0.22654125094413757,
-0.3379931151866913,
-0.2483931928873062,
-0.1844148188829422,
0.2364262491464615,
0.18061815202236176,
-0.08378461003303528,
0.03832574188709259,
-0.12445296347141266,
-0.6325026154518127,
-0.07378855347633362,
-0.21106627583503723,
-0.10647330433130264,
0.27435243129730225,
0.08357780426740646,
0.19498507678508759,
-0.1500473916530609,
-0.10504263639450073,
0.04884205013513565,
-0.17148512601852417,
-0.14950938522815704,
0.044801533222198486,
0.18864479660987854,
-0.13304533064365387,
-0.3036295473575592,
-0.22893820703029633,
-0.02367672324180603,
0.6361024379730225,
0.1428186297416687,
0.3744438588619232,
-0.17984330654144287,
-0.4488844871520996,
-0.09111680090427399,
0.1831206977367401,
0.016607265919446945,
0.23648078739643097,
-0.29681259393692017,
-0.5001826286315918,
0.009216535836458206,
0.4317801296710968,
0.1521647721529007,
-0.7144900560379028,
0.14721046388149261,
0.04792078584432602,
-0.578984797000885,
0.030647175386548042,
0.03313300013542175,
0.1840166300535202,
-0.28364983201026917,
-0.0939212292432785,
0.11586170643568039,
-0.10499976575374603,
-0.11074793338775635,
0.6161385774612427,
-0.08358417451381683,
0.35387811064720154,
0.17478060722351074,
-0.548912525177002,
-0.301424115896225,
0.2483637034893036,
-0.19824226200580597,
-0.18927793204784393,
0.01703936979174614,
0.251945436000824,
0.0009349538013339043,
0.07011771947145462,
-0.18862693011760712,
-0.07549944519996643,
0.4045608639717102,
-0.15315811336040497,
-0.23260898888111115,
-0.36029767990112305,
0.06673739105463028,
-0.23433081805706024,
0.2710054814815521,
-0.3446541130542755,
-0.45126739144325256,
0.11449753493070602,
0.38398897647857666,
-0.06100599467754364,
-0.25104936957359314,
-0.2633332312107086,
0.22153706848621368,
-0.4979162812232971,
0.19265389442443848,
0.25741875171661377,
0.33056145906448364,
0.22784066200256348,
0.04702863097190857,
0.2769959568977356,
-0.14840278029441833,
0.03726968541741371,
-0.21116487681865692,
0.08831021934747696,
0.03750859946012497,
-0.34963348507881165,
-0.4500731825828552,
-0.3013177812099457,
0.28863996267318726,
-0.39171671867370605,
0.178841695189476,
-0.6859167218208313,
0.15104424953460693,
-0.6422675251960754,
0.08691627532243729,
0.054518599063158035,
-0.7773743867874146,
-0.16679584980010986,
0.09329521656036377,
0.16805896162986755,
0.17403174936771393,
0.456783652305603,
-0.1174786388874054,
-0.4322245419025421,
-0.4268075227737427,
0.5827662944793701,
0.19285768270492554,
-0.6815323829650879,
0.20313292741775513,
0.019666902720928192,
0.09307461231946945,
0.2882201373577118,
-0.12570706009864807,
0.432722270488739,
0.48390525579452515,
0.1285606175661087,
0.0518355667591095,
1.0171695947647095,
0.1871243566274643,
0.20894959568977356,
-0.44435253739356995,
-0.4036329984664917,
0.25960031151771545,
-0.26077142357826233,
-0.16895262897014618,
0.6053653955459595,
0.1100601777434349,
-0.29512375593185425,
-0.014165990054607391,
0.19139255583286285,
-0.09125818312168121,
0.36041969060897827,
-0.2928755283355713,
0.49168917536735535,
0.5291414856910706,
0.658117413520813,
-0.12390802055597305,
0.10289440304040909,
-0.03379553183913231,
0.1427733302116394,
0.3064012825489044,
-0.7281972169876099,
-0.29383644461631775,
-0.21446488797664642,
0.8025797605514526,
-0.07437565922737122,
0.25560691952705383,
0.10213212668895721,
-0.09870840609073639,
0.2220924347639084,
-0.039621468633413315,
0.2719910442829132,
-0.13257865607738495,
-0.3561989665031433,
0.11755761504173279,
0.25358834862709045,
-0.17804798483848572,
0.08591675758361816,
0.02917572483420372,
-0.11550603061914444,
0.36970239877700806,
-0.1955769807100296,
-0.10082799941301346,
-0.05816323310136795,
0.09680032730102539,
0.3380983769893646,
0.36313024163246155,
0.14529834687709808,
0.35263046622276306,
-0.1734284907579422,
0.18990206718444824,
-0.025630304589867592,
0.24296024441719055,
-0.3082316517829895,
0.00702359015122056,
-0.03493736311793327,
-0.6266492605209351,
-0.0789300948381424,
0.3914088308811188,
0.14245425164699554,
0.04444429650902748,
-0.22184856235980988,
0.17691151797771454,
0.5241948962211609,
-0.2918912470340729,
-0.1890697032213211,
-0.07555794715881348,
-0.22536352276802063,
-0.0823943167924881,
-0.09750434756278992,
-0.38062459230422974,
0.39997902512550354,
0.20814922451972961,
-0.22710706293582916,
0.201712504029274,
-0.8863035440444946,
-0.2282116562128067,
0.4292377829551697,
0.17243912816047668,
-0.3014405071735382,
0.23455606400966644,
0.53314208984375,
-0.028633343055844307,
0.3924645781517029,
0.1342897117137909,
-0.04336773231625557,
-0.5128698348999023,
0.3940248489379883,
-0.5791865587234497,
0.541175901889801,
-0.41149747371673584,
-0.19210205972194672,
-0.533124566078186,
0.31234267354011536,
0.5287205576896667,
0.18203680217266083,
-0.24698448181152344,
-0.01912929117679596,
0.0022630568128079176,
0.04112982749938965,
0.4255576729774475,
-0.518094003200531,
-0.11371131241321564,
-0.8646752834320068,
-0.5682046413421631,
-0.09556961059570312,
0.09239715337753296,
-0.42424672842025757,
-0.10459981113672256,
0.009333503432571888,
-0.22694572806358337,
0.5096794366836548,
-0.025668833404779434,
0.793464720249176,
-0.15288063883781433,
0.08409127593040466,
-0.19130900502204895,
-0.20410750806331635,
-0.216157004237175,
-0.34586799144744873,
0.33079788088798523,
-0.0018064490286633372,
0.31351640820503235,
-0.09120645374059677,
0.19714637100696564,
-0.31403154134750366,
0.1599585860967636,
-0.14690910279750824,
0.4124718904495239,
0.01611161045730114,
-0.15592268109321594,
-0.3717535436153412,
-0.601288914680481,
0.21940039098262787,
-0.07018695771694183,
0.2514243721961975,
-0.08947063982486725,
0.007618334610015154,
-0.03565148636698723,
-0.1756051480770111,
-0.12922638654708862,
-0.30668720602989197,
0.12123085558414459,
-0.323055237531662
] |
Human bocavirus (HBoV) is a widespread respiratory virus. To improve diagnostic methods, we conducted immunoglobulin (Ig) G and IgM enzyme immunoassays with recombinant virus–like particles of HBoV as antigen. Acute-phase and follow-up serum samples from 258 wheezing children and single serum samples from 115 healthy adults in Finland were examined. Our assays had a sensitivity of 97% and a specificity of 99.5%. Of adults, 96% had immunity; none had an acute infection. Of 48 children with serologically diagnosed acute HBoV infections, 45 were viremic and 35 had virus in nasopharyngeal aspirates (NPAs). Of 39 HBoV NPA PCR–positive children co-infected with another virus, 64% had a serologically verified HBoV infection. HBoV caused illness of longer duration than rhinovirus and of equal severity to that of respiratory syncytial virus. Among children with bronchiolitis, >25% had acute HBoV infections. Accurate HBoV diagnosis requires serologic analysis or PCR of serum; PCR of NPAs alone is insufficient. | [
0.004388489760458469,
0.007847435772418976,
-0.020101668313145638,
0.028202330693602562,
-0.009747469797730446,
-0.00450148107483983,
0.010626308619976044,
0.008681338280439377,
-0.01789827272295952,
0.0031038401648402214,
-0.004200116731226444,
0.014971932396292686,
-0.012845151126384735,
0.002879606792703271,
-0.0012194097507745028,
-0.002442070050165057,
-0.014429491013288498,
-0.014209140092134476,
0.013132655993103981,
0.01249738596379757,
-0.0025071310810744762,
0.009644156321883202,
0.010668981820344925,
-0.035757213830947876,
-0.010852797888219357,
0.0264469962567091,
-0.003084610216319561,
0.003678940236568451,
0.009900991804897785,
-0.007078257389366627,
0.03250759094953537,
-0.002451427048072219,
0.008127445355057716,
-0.02510814741253853,
-0.0005072180647403002,
-0.011464370414614677,
-0.005792757496237755,
0.02245565876364708,
0.003930740058422089,
-0.004063224419951439,
-0.03047046810388565,
-0.009994957596063614,
0.004148451145738363,
-0.016976971179246902,
-0.004821174778044224,
-0.009217590093612671,
-0.007423278875648975,
0.0019526618998497725,
0.004318240564316511,
0.005486617796123028,
-0.007411939091980457,
0.006777646951377392,
-0.009967832826077938,
0.027599496766924858,
-0.0069963401183485985,
0.01932275854051113,
0.01884767971932888,
0.0138994250446558,
0.0019320212304592133,
-0.01722293347120285,
0.024606838822364807,
-0.022364970296621323,
-0.010010950267314911,
0.0002923952415585518,
-0.007017937488853931,
-0.0668078288435936,
-0.020575204864144325,
-0.005505450069904327,
-0.0032464321702718735,
-0.0013069307897239923,
-0.013723364099860191,
0.0168021097779274,
0.010224166326224804,
0.00472944974899292,
-0.0301804319024086,
0.01445079781115055,
-0.007478618528693914,
-0.007186334580183029,
-0.014013446867465973,
-0.005464957095682621,
0.0294218547642231,
0.010233954526484013,
0.029559455811977386,
0.034071050584316254,
0.006298318039625883,
0.03001311980187893,
-0.04619450867176056,
-0.02431236021220684,
-0.013391237705945969,
-0.01990887150168419,
0.0001947544515132904,
-0.007114602718502283,
-0.03483692929148674,
0.012203408405184746,
-0.03784138709306717,
-0.0006098906742408872,
-0.004713072441518307,
-0.042033303529024124,
-0.016776802018284798,
-0.02699287235736847,
-0.026275301352143288,
-0.020111240446567535,
0.02175583690404892,
0.006622849032282829,
-0.022962993010878563,
0.006412615068256855,
-0.01276998408138752,
0.009294800460338593,
0.03339576721191406,
0.007282343693077564,
0.004232566803693771,
-0.0033026926685124636,
0.028919028118252754,
0.03791310638189316,
0.0015872875228524208,
-0.012327980250120163,
-0.011332029476761818,
0.0006974018178880215,
0.008810009807348251,
-0.004430767614394426,
-0.0016942471265792847,
-0.015832817181944847,
0.003191374707967043,
-0.015298507176339626,
0.007321462966501713,
-0.012601301074028015,
0.015229986980557442,
-0.016479721292853355,
0.020615486428141594,
-0.0025100961793214083,
-0.0020269686356186867,
0.005470068659633398,
-0.022826021537184715,
-0.008540487848222256,
-0.005869584623724222,
-0.00590527756139636,
-0.005364095792174339,
0.0014188671484589577,
-0.0026567778550088406,
-0.008112619630992413,
-0.01878257468342781,
0.006701217032968998,
0.007398912683129311,
0.008090443909168243,
0.006874389480799437,
0.006531950552016497,
-0.04335145652294159,
0.01083003357052803,
0.02363390102982521,
-0.036176398396492004,
0.0169602669775486,
-0.011712439358234406,
-0.03111732378602028,
-0.000871569849550724,
0.029883865267038345,
-0.01201635506004095,
-0.0034138448536396027,
-0.03157556802034378,
0.014534108340740204,
0.010265542194247246,
0.010727912187576294,
-0.03591153770685196,
0.013413968496024609,
0.010219722986221313,
0.008560225367546082,
0.00918425153940916,
0.021824292838573456,
-0.0131631288677454,
-0.00808010809123516,
0.007317091338336468,
-0.008123032748699188,
-0.013604010455310345,
-0.00011008512228727341,
0.007104004267603159,
0.015068613924086094,
-0.00495766568928957,
-0.011770733632147312,
0.004722481593489647,
-0.008910673670470715,
0.06669542193412781,
0.010361856780946255,
0.012704421766102314,
-0.02485942840576172,
0.005123083479702473,
0.031824953854084015,
-0.004945790395140648,
0.007058471441268921,
-0.014171916991472244,
-0.022711649537086487,
-0.020941944792866707,
-0.01332361064851284,
0.024926597252488136,
-0.011386319994926453,
-0.008252891711890697,
0.022128969430923462,
0.0020698378793895245,
0.013521309942007065,
0.013206012547016144,
-0.0001474160235375166,
-0.003195366822183132,
0.012161226943135262,
0.015058446675539017,
0.02463369071483612,
0.017149843275547028,
-0.044145748019218445,
0.011889787390828133,
0.005093375686556101,
0.006470344495028257,
-0.029119495302438736,
0.02110385149717331,
0.012638265267014503,
-0.012076144106686115,
0.0046888613142073154,
-0.009655460715293884,
-0.017336547374725342,
0.0029882786329835653,
0.0010745283216238022,
0.011667531915009022,
0.0013548354618251324,
-0.0166312288492918,
-0.000046596513129770756,
-0.011429626494646072,
-0.03255731612443924,
0.013537507504224777,
-0.012094857171177864,
-0.010478375479578972,
-0.0035705971531569958,
0.008705363608896732,
-0.021462038159370422,
0.015948742628097534,
-0.02748580276966095,
-0.021220780909061432,
-0.01181238517165184,
-0.017843453213572502,
0.0059744818136096,
0.01701861247420311,
0.013769128359854221,
-0.01838771626353264,
0.009358297102153301,
-0.0220778901129961,
0.004221675451844931,
0.0018390949117019773,
0.010097227990627289,
0.040325917303562164,
-0.004736338742077351,
-0.0024236347526311874,
0.01875198446214199,
0.009332654997706413,
-0.005467928014695644,
0.00015919929137453437,
0.008623954840004444,
0.013863818719983101,
0.02108289673924446,
-0.03117445483803749,
0.023444056510925293,
-0.014977872371673584,
0.013328371569514275,
-0.016518186777830124,
0.025400621816515923,
0.007986501790583134,
0.00618908042088151,
0.0044512455351650715,
-0.013748887926340103,
0.010117178782820702,
0.02215689793229103,
-0.0014854895416647196,
0.017845384776592255,
0.03459829092025757,
0.01422158908098936,
-0.010952094569802284,
0.005381980910897255,
-0.011316133663058281,
-0.00470647681504488,
-0.0814833715558052,
-0.011349904350936413,
-0.006992804817855358,
-0.022358888760209084,
0.009516122750937939,
0.013113532215356827,
0.006256043910980225,
0.009760554879903793,
-0.006568214390426874,
0.006011543329805136,
0.005963863804936409,
0.022179052233695984,
-0.0009494027472101152,
-0.013042282313108444,
0.001375045976601541,
-0.00434490293264389,
0.013058428652584553,
-0.02561914175748825,
-0.009294852614402771,
-0.022880330681800842,
-0.018538061529397964,
0.021267428994178772,
0.04294675961136818,
0.004142301622778177,
-0.017705146223306656,
-0.008217534981667995,
0.019707273691892624,
-0.002910796320065856,
0.003098685760051012,
0.012987954542040825,
0.0018809798639267683,
-0.0046588461846113205,
0.04053245484828949,
0.00037426548078656197,
0.019836299121379852,
0.0011588158085942268,
-0.014194279909133911,
-0.005379861686378717,
-0.018757425248622894,
0.0050408621318638325,
-0.034912146627902985,
0.00956348329782486,
0.01225018035620451,
-0.003896620823070407,
0.01359143853187561,
0.011271786876022816,
-0.009448697790503502,
0.025328854098916054,
0.012847231701016426,
-0.015163015574216843,
-0.0017134081572294235,
-0.012363366782665253,
0.038625869899988174,
0.017632078379392624,
-0.010829394683241844,
0.00269497511908412,
-0.04162651300430298,
0.03764066845178604,
-0.005054549314081669,
-0.002497392939403653,
-0.009517841041088104,
-0.005167076829820871,
-0.006995704490691423,
0.025059251114726067,
-0.003198235062882304,
0.01566503196954727,
0.011559538543224335,
0.005653572268784046,
-0.008885597810149193,
0.008813653141260147,
0.0168171264231205,
0.00606513861566782,
-0.010136852040886879,
-0.0101259620860219,
0.0054755620658397675,
0.0034897876903414726,
-0.016559913754463196,
-0.004635474178940058,
-0.02267773263156414,
-0.01154941227287054,
-0.0008979616686701775,
0.01822604611515999,
-0.011201635003089905,
-0.0014853854663670063,
0.0007542041130363941,
0.006451616063714027,
0.007497438229620457,
0.02819463238120079,
0.008564923889935017,
-0.01464801374822855,
0.04125024005770683,
0.025675196200609207,
-0.0197921022772789,
0.012827672064304352,
-0.003232519142329693,
-0.03128061816096306,
-0.002269955351948738,
0.023833638057112694,
0.016326075419783592,
0.008505236357450485,
-0.03929514065384865,
-0.013455843552947044,
0.022638030350208282,
-0.007683968171477318,
-0.04051383212208748,
0.02117522992193699,
-0.018001049757003784,
-0.00757894292473793,
-0.0002633804106153548,
-0.007166248746216297,
0.012781343422830105,
0.019205229356884956,
-0.012697765603661537,
-0.013937822543084621,
0.014858284965157509,
0.0027843336574733257,
-0.006400801241397858,
-0.0063804276287555695,
0.07167486846446991,
0.01133938878774643,
0.00006979773752391338,
-0.022876407951116562,
0.028799228370189667,
-0.02843676134943962,
0.012530452571809292,
-0.019528694450855255,
0.0032446528784930706,
-0.010366766713559628,
0.013446956872940063,
-0.03035358153283596,
0.009718005545437336,
-0.012558834627270699,
0.0199391208589077,
0.024454068392515182,
0.019317975267767906,
-0.005036007612943649,
-0.01154713798314333,
-0.0063347239047288895,
-0.011728191748261452,
0.012211877852678299,
-0.007004300598055124,
-0.01125104445964098,
0.014107784256339073,
-0.010508747771382332,
0.008708890527486801,
-0.015078188851475716,
-0.011477339081466198,
0.017811700701713562,
0.01655365154147148,
0.0020518735982477665,
-0.010844482108950615,
0.020218245685100555,
0.01680946536362171,
-0.020136874169111252,
0.009227463975548744,
0.0019460208714008331,
0.004315274301916361,
-0.0019174795597791672,
-0.045944955199956894,
-0.017128756269812584,
0.009141095913946629,
0.013744138181209564,
-0.014373628422617912,
0.0016680629923939705,
0.014305643737316132,
-0.005780487321317196,
-0.021513424813747406,
-0.013930524699389935,
0.022209960967302322,
-0.003063864540308714,
0.007551233284175396,
0.009526091627776623,
0.021950967609882355,
0.01792098581790924,
0.01820184849202633,
-0.00345480814576149,
-0.011331029236316681,
-0.03603731095790863,
0.017590699717402458,
-0.013299312442541122,
-0.022786585614085197,
-0.0019027914386242628,
0.005420911591500044,
-0.003589760046452284,
-0.006384009029716253,
0.016111958771944046,
-0.006633440498262644,
-0.015875333920121193,
-0.004068916197866201,
-0.01903950423002243,
-0.018083147704601288,
0.001520073041319847,
-0.040577929466962814,
-0.015202958136796951,
0.03423873335123062,
0.026513181626796722,
0.017198367044329643,
0.013766538351774216,
-0.006147497799247503,
0.01247673574835062,
0.027305476367473602,
-0.032792411744594574,
0.008496023714542389,
0.013453477993607521,
0.0014722251798957586,
-0.07418766617774963,
-0.017156902700662613,
0.012243060395121574,
-0.006731429137289524,
0.007583071943372488,
0.003780534490942955,
-0.01855544000864029,
0.0015803435817360878,
-0.014661682769656181,
-0.012232126668095589,
0.0020158705301582813,
0.01942799612879753,
0.012898121029138565,
0.011722876690328121,
0.012248741462826729,
0.020350439473986626,
-0.019742779433727264,
-0.013571429066359997,
-0.029319673776626587,
0.006762396544218063,
-0.025658339262008667,
-0.01050821878015995,
-0.011462966911494732,
0.01801656186580658,
-0.007644330617040396,
-0.08098261058330536,
0.03744130581617355,
-0.010363113135099411,
-0.016248637810349464,
0.01382112130522728,
-0.0026472886092960835,
0.014811011031270027,
-0.021713610738515854,
-0.0245504193007946,
-0.016992297023534775,
0.011301912367343903,
-0.013165712356567383,
0.010758347809314728,
-0.02390271984040737,
0.02754375711083412,
-0.010268966667354107,
-0.0024844736326485872,
0.03744971379637718,
0.024516094475984573,
0.008996040560305119,
0.005522595252841711,
0.02871161326766014,
-0.006318640895187855,
0.017944999039173126,
-0.007053978741168976,
-0.02520497888326645,
-0.0019009413663297892,
0.01585257612168789,
-0.011465875431895256,
-0.01907866820693016,
-0.008381782099604607,
0.008426087908446789,
-0.007007489912211895,
-0.015177324414253235,
0.004221552982926369,
-0.009591400623321533,
0.03798232972621918,
-0.012193361297249794,
0.001471581868827343,
-0.005352601874619722,
-0.004393159411847591,
0.007127432618290186,
0.04537545517086983,
-0.0020549758337438107,
0.026260290294885635,
-0.025032881647348404,
0.007297832053154707,
-0.004897802136838436,
0.02282649464905262,
0.011217933148145676,
-0.00014479178935289383,
0.007944535464048386,
-0.010264448821544647,
-0.010942474938929081,
0.002311068819835782,
-0.019025621935725212,
-0.006683595012873411,
-0.005102851428091526,
-0.030272535979747772,
0.02663612738251686,
-0.01731877587735653,
0.01594845950603485,
0.011591185815632343,
0.07158270478248596,
0.01281385961920023,
0.017945585772395134,
-0.006996129639446735,
-0.024791453033685684,
0.00945909135043621,
0.02727626822888851,
0.028319554403424263,
-0.013999875634908676,
-0.004815566353499889,
-0.014391707256436348,
-0.0035268724896013737,
-0.04460669681429863,
0.011154402047395706,
-0.012123859487473965,
0.017091460525989532,
0.007669524755328894,
0.0009007027838379145,
-0.017535600811243057,
-0.0021303147077560425,
0.001337289810180664,
-0.018528349697589874,
-0.012870614416897297,
-0.029175641015172005,
0.020931264385581017,
-0.006531916558742523,
-0.022151293233036995,
-0.008611481636762619,
-0.0035606222227215767,
-0.004312421195209026,
-0.01603563316166401,
0.011197768151760101,
0.008828644640743732,
-0.02488081529736519,
-0.0019463654607534409,
-0.019118160009384155,
-0.01884172111749649,
0.010792703367769718,
0.006422202102839947,
-0.0011115162633359432,
-0.002718248637393117,
0.010966244153678417,
0.0021632832940667868,
-0.03425854071974754,
0.014719942584633827,
-0.042304858565330505,
-0.0007386542856693268,
-0.0009388253092765808,
0.024028582498431206,
0.02244003675878048,
0.023150620982050896,
0.005703801289200783,
0.010739998891949654,
0.0028169977013021708,
-0.013047742657363415,
0.009664308279752731,
-0.05550757795572281,
0.018135208636522293,
-0.0035253106616437435,
0.014992985874414444,
0.006430699490010738,
-0.017406443133950233,
-0.0009685452096164227,
-0.023314926773309708,
0.016556113958358765,
-0.03902135416865349,
0.0031949400436133146,
-0.013918628916144371,
-0.01692315563559532,
0.013598902150988579,
-0.012496904470026493,
0.011689353734254837,
0.010484572499990463,
0.004345604684203863,
0.005660913418978453,
0.029253073036670685,
0.02775438502430916,
0.007539032492786646,
0.0052987681701779366,
-0.005297520663589239,
-0.011330896988511086,
-0.030104808509349823,
0.015280384570360184,
-0.005543871782720089,
-0.02161724865436554,
0.0018125255592167377,
0.030809827148914337,
-0.02695048414170742,
-0.0029847570694983006,
0.003200683044269681,
0.007808198221027851,
0.01848568022251129,
0.004355098120868206,
-0.011706804856657982,
0.0065575530752539635,
0.034338563680648804,
0.004712644033133984,
0.009132160805165768,
0.0064574237912893295,
-0.005761811509728432,
0.01136859878897667,
-0.0197259820997715,
-0.017956702038645744,
0.033521126955747604,
-0.0040291487239301205,
-0.007282514590770006,
0.013754786923527718,
0.016427794471383095,
-0.0038204118609428406,
0.029393918812274933,
0.01331876777112484,
0.021092452108860016,
0.004799592308700085,
0.009577838703989983,
-0.0034833401441574097,
0.013067089021205902,
0.010929670184850693,
-0.02065737545490265,
0.013251680880784988,
-0.01624232903122902,
0.004503718577325344,
-0.003970986697822809,
0.01690446399152279,
0.023187484592199326,
-0.019656311720609665,
-0.007768499664962292,
-0.011996850371360779,
-0.008201460354030132,
-0.00408891448751092,
0.006975929718464613,
0.020572714507579803,
-0.017867758870124817,
0.012994169257581234,
0.010578140616416931,
-0.013662675395607948,
-0.014667096547782421,
-0.018839746713638306,
-0.02758157067000866,
-0.016364913433790207,
-0.019940869882702827,
0.006864827126264572,
-0.005496290512382984,
-0.011429253965616226,
-0.024391209706664085,
0.00898913387209177,
-0.02176484651863575,
-0.018130948767066002,
-0.013068350031971931,
0.01218641921877861,
0.017118774354457855,
-0.01815519854426384,
-0.0012229342246428132,
-0.013326628133654594,
-0.006808274891227484,
0.007510780356824398,
-0.01015305146574974,
-0.001018207287415862,
-0.0063257403671741486,
-0.0025758135598152876,
0.010682271793484688,
0.0005823913961648941,
-0.001280666794627905,
0.009633522480726242,
-0.005011309869587421,
0.010197622701525688,
0.026786047965288162,
0.026481986045837402,
0.023930493742227554,
0.0017163502052426338,
0.007126188836991787,
0.011755227111279964,
-0.015526892617344856,
0.01986166089773178,
-0.006207765080034733,
-0.04239453002810478,
-0.0001187608577311039,
-0.015152722597122192,
0.005533098243176937,
-0.002537823747843504,
0.03154151141643524,
0.01293972134590149,
-0.011589575558900833,
-0.008768422529101372,
-0.01470925658941269,
-0.03072555735707283,
-0.0029738019220530987,
-0.009446476586163044,
0.005742969922721386,
0.025883203372359276,
0.005524537526071072,
-0.03393741697072983,
-0.0052300989627838135,
-0.0072182901203632355,
0.0173842404037714,
-0.002319280756637454,
0.009142751805484295,
-0.024255774915218353,
-0.018829045817255974,
-0.004221006296575069,
0.027718674391508102,
0.0086357481777668,
-0.006531486287713051
] | [
-0.2478507161140442,
0.09030567109584808,
-0.0034861795138567686,
-0.4715888500213623,
0.10180675238370895,
0.3099854588508606,
0.40042904019355774,
0.0799545869231224,
-0.0819745734333992,
-0.1592167615890503,
-0.01904037408530712,
0.39916956424713135,
-0.5427660346031189,
-0.2385789006948471,
0.05940014868974686,
0.7182479500770569,
0.28205254673957825,
0.3701104521751404,
-0.21859222650527954,
-0.4428022801876068,
0.0588328018784523,
-0.40715429186820984,
0.4730650782585144,
-0.022374717518687248,
-0.20685037970542908,
-0.10930661112070084,
0.5395539999008179,
0.348049134016037,
0.4308946132659912,
-0.2862080931663513,
-0.23586755990982056,
0.6628503799438477,
0.3878786563873291,
-0.4481245279312134,
-0.01368393748998642,
-0.03739464282989502,
-0.701671302318573,
0.04296353831887245,
-0.26284077763557434,
-0.276011198759079,
-0.2184523493051529,
-0.5537545680999756,
-0.2649361491203308,
0.30530381202697754,
0.024759065359830856,
-0.6150234937667847,
-0.9133628010749817,
0.9418148994445801,
-0.3056921064853668,
0.23545992374420166,
0.06558607518672943,
0.3201369643211365,
-0.006298610009253025,
-0.024159910157322884,
0.4452073574066162,
0.025690535083413124,
-0.7741527557373047,
-0.7369767427444458,
0.3996562063694,
-0.28538528084754944,
0.3115196228027344,
0.26364433765411377,
0.008402440696954727,
0.08502788096666336,
-0.4616968035697937,
0.9091346263885498,
-0.0390908308327198,
-0.026145057752728462,
-0.4241846799850464,
-0.2777039706707001,
0.4024488031864166,
-0.370352566242218,
-0.15113884210586548,
-0.016335146501660347,
-0.044716592878103256,
-0.38683071732521057,
-0.6477993726730347,
-0.3104279935359955,
0.0227225162088871,
0.40681561827659607,
0.024181701242923737,
-0.19666995108127594,
0.1641412228345871,
-0.14260461926460266,
0.18678845465183258,
0.48362308740615845,
0.003474948927760124,
0.7223995327949524,
-0.33225229382514954,
0.16987165808677673,
0.09475911408662796,
0.3508332371711731,
0.9076469540596008,
0.24348606169223785,
0.1931942254304886,
0.43493688106536865,
-0.3189658522605896,
0.35586288571357727,
0.014075901359319687,
0.1709083467721939,
-0.5951759815216064,
0.4394879639148712,
-0.15358981490135193,
-0.38574063777923584,
-0.23581339418888092,
0.08910311013460159,
-0.2616083323955536,
-0.5997444987297058,
-0.43353453278541565,
-0.045608364045619965,
-0.39654386043548584,
-0.5346421599388123,
-0.5351914763450623,
-0.3758098781108856,
-0.23908063769340515,
0.1226595789194107,
-0.08910486847162247,
-0.5550665855407715,
0.16735289990901947,
-0.07098889350891113,
-0.5791324973106384,
0.7525039911270142,
-0.040447019040584564,
0.4341464638710022,
0.22244597971439362,
-0.3724268078804016,
0.05050579831004143,
0.0013136814814060926,
0.06405825912952423,
0.8290147185325623,
0.33234789967536926,
0.9096764922142029,
-0.15765097737312317,
0.4615404009819031,
-0.13374531269073486,
0.19917531311511993,
-0.2652622163295746,
0.0035022287629544735,
0.3608013689517975,
-0.35248664021492004,
-0.7564516067504883,
-0.7135608196258545,
-0.44829893112182617,
0.4376992881298065,
-0.33336296677589417,
-0.25365257263183594,
-0.27481991052627563,
0.05792422592639923,
-0.2729542553424835,
-0.763964056968689,
0.03350614383816719,
-0.3672529458999634,
-0.27231666445732117,
-0.2545488178730011,
0.39100444316864014,
0.16997221112251282,
0.06359871476888657,
-0.23441390693187714,
-0.1429685652256012,
0.10525617748498917,
0.34543296694755554,
0.35215869545936584,
-0.35515594482421875,
-0.31091150641441345,
0.43233510851860046,
-0.07788993418216705,
0.10348211228847504,
0.4549359977245331,
0.022159265354275703,
-0.09658772498369217,
-0.5788512825965881,
-0.4972728490829468,
0.6032597422599792,
-0.6724502444267273,
-0.07547776401042938,
-0.1455884873867035,
0.5567792654037476,
-0.22872516512870789,
0.3648544251918793,
0.18387345969676971,
-0.6845109462738037,
-0.027390088886022568,
-0.3335959017276764,
-0.3368843197822571,
0.8291494846343994,
0.05556518957018852,
-0.13899004459381104,
0.19799669086933136,
0.09189785271883011,
0.07456020265817642,
-0.5854257345199585,
-0.22283971309661865,
0.7404406666755676,
0.11371243000030518,
1.1290894746780396,
-0.4503500461578369,
-0.40570777654647827,
1.450838565826416,
0.7252019047737122,
0.15721359848976135,
-0.6893917918205261,
0.4749237895011902,
0.7891645431518555,
-0.45007312297821045,
-0.7290450930595398,
0.04065217822790146,
-0.1275920867919922,
-0.16042588651180267,
-0.04729682579636574,
0.6080424785614014,
0.17071384191513062,
-0.11631482094526291,
-0.09330404549837112,
-0.815923273563385,
0.24829798936843872,
0.22582830488681793,
0.08809222280979156,
0.1714993566274643,
-0.09444665908813477,
0.07706697285175323,
0.6980517506599426,
-0.7884687185287476,
0.41380199790000916,
0.7577359080314636,
-0.3330425024032593,
0.634910523891449,
0.5960970520973206,
0.3510766625404358,
0.8780874609947205,
-0.8229919075965881,
0.44203972816467285,
-0.5455598831176758,
0.24946705996990204,
-0.5615436434745789,
-0.46418851613998413,
0.31476643681526184,
0.056121595203876495,
-0.10269404202699661,
0.10265132039785385,
0.346027672290802,
0.10699624568223953,
0.7728248834609985,
-0.25169408321380615,
-0.23391743004322052,
0.13181619346141815,
-0.31423383951187134,
-0.0418962799012661,
-0.19390983879566193,
-0.7630270719528198,
0.19804562628269196,
0.014719665981829166,
0.608748733997345,
0.0844164788722992,
-0.08495459705591202,
0.25838157534599304,
0.10398529469966888,
0.41097384691238403,
-0.3618706464767456,
0.24358023703098297,
-0.2896285951137543,
-0.22404924035072327,
0.22792813181877136,
-0.048354435712099075,
0.3886473476886749,
0.07243046164512634,
-0.22465471923351288,
-0.553112268447876,
-0.45283010601997375,
0.7054884433746338,
0.7927329540252686,
0.9490431547164917,
0.235104501247406,
-0.75674968957901,
0.013210720382630825,
0.37657657265663147,
-0.09390000998973846,
0.3016567528247833,
0.2959880530834198,
-0.3305705487728119,
-0.30362701416015625,
-0.5623877048492432,
-0.061931904405355453,
0.6615699529647827,
-0.5152071118354797,
0.10593129694461823,
-0.26364126801490784,
-0.18118438124656677,
-0.37629199028015137,
-0.7091518640518188,
-0.23039312660694122,
-0.3649876117706299,
0.34263983368873596,
0.3402273654937744,
0.02529911696910858,
0.25411105155944824,
-0.3027926981449127,
0.3882147967815399,
0.38566598296165466,
0.6343353986740112,
-0.09611856937408447,
-0.1916496902704239,
0.38834109902381897,
-0.6434495449066162,
-0.2353544533252716,
0.10966133326292038,
0.3416173458099365,
-0.08524397015571594,
0.557071328163147,
-5.79618501663208,
0.0904211699962616,
-0.40096035599708557,
-0.4637276232242584,
-0.018502850085496902,
0.03944011405110359,
0.9522213935852051,
-0.23449376225471497,
0.024383345618844032,
0.14898349344730377,
0.651520311832428,
0.5081250667572021,
0.41845807433128357,
-0.2113645374774933,
-0.060810111463069916,
-0.23268140852451324,
-0.3519783318042755,
-0.11524799466133118,
0.5466949343681335,
0.023989960551261902,
0.4220077097415924,
-0.20691774785518646,
-0.5629133582115173,
0.22307559847831726,
-0.27121666073799133,
0.4053983688354492,
-0.06654268503189087,
0.18026676774024963,
-0.012129883281886578,
-0.23226499557495117,
-0.13556408882141113,
-0.5625354051589966,
0.043107688426971436,
-0.216103196144104,
-0.09686487913131714,
-0.14299151301383972,
0.3027131259441376,
-0.31007641553878784,
0.06166115775704384,
-0.2290564626455307,
0.12175138294696808,
-0.2309376448392868,
-0.003800312289968133,
-0.49036905169487,
-0.236909419298172,
-0.34396740794181824,
-0.25961804389953613,
0.22641503810882568,
-0.34218671917915344,
0.6182329058647156,
0.5440390706062317,
-0.36927124857902527,
-0.03374987840652466,
1.198053240776062,
0.6504085659980774,
0.32787036895751953,
0.004168508108705282,
-0.16413208842277527,
-0.4960675537586212,
0.12086831778287888,
-0.05927148461341858,
-0.23372170329093933,
-0.13407838344573975,
-0.8194593191146851,
0.2598772346973419,
0.3144022226333618,
-0.46223556995391846,
-0.4160081744194031,
0.4712594449520111,
-0.007194802165031433,
-0.1433904767036438,
-0.025889163836836815,
-0.1713927984237671,
-0.7762205600738525,
0.389018714427948,
-0.4362366199493408,
0.2595103681087494,
-0.1401837021112442,
-0.3537711501121521,
-0.32212796807289124,
0.08903492242097855,
-0.24259637296199799,
-0.39195406436920166,
-0.4531905949115753,
-0.2202969342470169,
-0.8017902970314026,
0.31124648451805115,
-0.08728575706481934,
-0.059008218348026276,
-0.10208427906036377,
0.3217558264732361,
-0.5241453647613525,
-0.0759706050157547,
0.4573700726032257,
-0.03519036993384361,
0.09381502121686935,
-0.17252549529075623,
0.5021577477455139,
0.8043535947799683,
0.09957670420408249,
0.917274534702301,
-0.5294597744941711,
-0.25424477458000183,
-1.0816538333892822,
-0.2894822061061859,
0.26460716128349304,
-0.3084726333618164,
-0.1530718207359314,
0.9496008157730103,
-0.5392553210258484,
0.3065571188926697,
-0.05227868631482124,
-0.44203853607177734,
0.05759347230195999,
1.1223758459091187,
-0.030146067962050438,
0.3346874415874481,
0.25442707538604736,
0.4061986804008484,
0.07111884653568268,
0.3409208059310913,
0.3636121451854706,
-0.3587647080421448,
0.6418556571006775,
0.270986407995224,
-0.17821656167507172,
0.3301905691623688,
0.26678720116615295,
-0.9325262308120728,
-0.11348601430654526,
0.2970317304134369,
0.1225895956158638,
0.13907687366008759,
0.297174334526062,
0.6555373668670654,
0.025383491069078445,
-0.6542688012123108,
-0.3285712003707886,
0.46979591250419617,
-0.27302709221839905,
0.21481899917125702,
-0.18511095643043518,
-0.027350930497050285,
0.2716597020626068,
-0.050706930458545685,
0.04365013167262077,
-0.22914227843284607,
0.08943091332912445,
-0.22149169445037842,
-0.23254534602165222,
0.001020254334434867,
-0.0015020816354081035,
0.09268497675657272,
0.35320723056793213,
-0.44795677065849304,
0.49542179703712463,
0.10832186788320541,
0.3871826231479645,
0.2786712646484375,
-0.3903048634529114,
0.20637965202331543,
0.002818151842802763,
-0.7747642993927002,
-0.17749422788619995,
-0.44559794664382935,
-0.253951758146286,
0.0035416651517152786,
-0.6025415658950806,
0.05311238765716553,
0.3494091033935547,
-0.30538251996040344,
-0.1607142686843872,
0.12426099181175232,
-0.33378806710243225,
-0.08433657884597778,
0.12308117747306824,
-0.4090658128261566,
-0.32374414801597595,
-0.1546572893857956,
0.5579752922058105,
0.24158073961734772,
-0.025074414908885956,
0.06190253794193268,
0.7001097798347473,
0.5846592783927917,
0.5790310502052307,
0.0064411405473947525,
-0.2393375039100647,
-0.14080910384655,
-0.14012779295444489,
-0.16239017248153687,
0.30021408200263977,
0.2986547648906708,
-0.4303775727748871,
-0.09167326986789703,
-0.0751134604215622,
0.17729192972183228,
0.2299399971961975,
-0.38391777873039246,
0.15024195611476898,
-0.13311287760734558,
0.42293646931648254,
-0.19085930287837982,
0.29283854365348816,
-0.15739567577838898,
-0.17927643656730652,
-0.07994046062231064,
-0.2745904326438904,
-0.23396851122379303,
-0.14402888715267181,
-0.21063892543315887,
-0.6487778425216675,
0.11771824955940247,
0.5727822780609131,
-0.11413805186748505,
0.3957687020301819,
-0.11223921179771423,
-0.5060124397277832,
-0.06232990324497223,
0.06117391958832741,
-0.25090810656547546,
-0.325847864151001,
-0.12108370661735535,
-0.2786269783973694,
-0.3904937207698822,
0.8179761171340942,
0.16531260311603546,
-1.1901034116744995,
0.6222659945487976,
0.5997774600982666,
-0.0911284014582634,
-0.20957688987255096,
0.555694043636322,
0.24741603434085846,
-0.3883945047855377,
-0.6586864590644836,
-0.2592025101184845,
-0.2008017748594284,
-0.20865701138973236,
0.5680040121078491,
0.24501509964466095,
0.594627320766449,
-0.2529071867465973,
0.041613128036260605,
0.06222434341907501,
-0.014832300134003162,
0.3657572269439697,
-0.4381234049797058,
-0.4186338484287262,
0.24597536027431488,
0.23232704401016235,
-0.238095223903656,
-0.057737160474061966,
0.1887655407190323,
1.0519163608551025,
-0.06610752642154694,
-0.0488477423787117,
-0.5718874335289001,
-0.24438759684562683,
0.1329704225063324,
-0.2806762158870697,
0.2202150672674179,
-0.10237573087215424,
-0.08732299506664276,
0.09911120682954788,
-0.2556942403316498,
0.07553043216466904,
-0.37816572189331055,
0.19821037352085114,
0.2518540620803833,
0.12970983982086182,
0.004768204875290394,
0.8839268684387207,
0.9495803117752075,
-0.5288594961166382,
0.5319218039512634,
-0.38566961884498596,
-0.40195101499557495,
-0.050676267594099045,
0.30588003993034363,
-0.4861224293708801,
-0.2281188666820526,
-0.05594051629304886,
-0.021931910887360573,
-0.044946420937776566,
-0.1430821567773819,
-0.26609212160110474,
-0.22372685372829437,
0.07211857289075851,
-0.25662940740585327,
-0.15433108806610107,
0.1517053246498108,
-1.0407465696334839,
-0.024817319586873055,
0.17442628741264343,
0.1140584647655487,
0.05094720795750618,
0.45634108781814575,
-0.36210212111473083,
-0.09336033463478088,
-0.8524877429008484,
0.9266181588172913,
0.2389681488275528,
-0.4537350535392761,
0.31162869930267334,
-0.032221291214227676,
0.07923229038715363,
0.34347617626190186,
-0.1849040687084198,
0.08694104105234146,
0.055319298058748245,
0.09382633864879608,
0.5385230779647827,
-0.01315063051879406,
-0.3971826136112213,
0.2724034786224365,
-0.2594551146030426,
-0.3561088740825653,
0.062145087867975235,
0.17094478011131287,
0.11343096196651459,
0.9107102155685425,
0.2173842191696167,
0.06465701013803482,
-0.02358184941112995,
0.7738627195358276,
-0.2920788824558258,
-0.06164368987083435,
0.5141531825065613,
0.6950762271881104,
0.7648524045944214,
-0.13818281888961792,
-0.2355465143918991,
0.2756992280483246,
0.029153024777770042,
0.22724679112434387,
0.07517082989215851,
-0.368463933467865,
-0.2982666790485382,
0.2193811684846878,
0.565768837928772,
0.438387393951416,
-0.20275892317295074,
0.08076183497905731,
0.04945959523320198,
0.30722635984420776,
-0.020991139113903046,
0.11152199655771255,
0.1879717856645584,
-0.09052098542451859,
0.31755587458610535,
-0.5410231351852417,
0.1086747869849205,
0.2869945168495178,
-0.24785283207893372,
0.3225805163383484,
-0.08039670437574387,
-0.5022676587104797,
-0.9057458639144897,
0.3100448548793793,
-0.31770122051239014,
0.14491932094097137,
0.6948297023773193,
0.6962444186210632,
-0.02585274539887905,
-0.21120479702949524,
0.12139195203781128,
0.06347090750932693,
0.4400142431259155,
-0.10512732714414597,
0.24321435391902924,
-0.023997841402888298,
-0.733352780342102,
0.488774836063385,
0.10080884397029877,
-0.06717564910650253,
-0.1319400668144226,
0.053366243839263916,
-0.6052881479263306,
0.37022966146469116,
-0.6411118507385254,
0.007475749123841524,
-0.025117697194218636,
-0.3153969943523407,
-0.36601054668426514,
0.02055888995528221,
-0.30373677611351013,
-0.011142306961119175,
0.23740923404693604,
-0.4829382002353668,
0.17790070176124573,
-0.4321853816509247,
0.10390999913215637,
0.5121572017669678,
-0.07472936809062958,
-0.2779965400695801,
0.13890956342220306,
0.002747950376942754,
0.2213483601808548,
0.314963698387146,
-0.14310501515865326,
0.06318195164203644,
-0.17860674858093262,
-0.007884700782597065,
-0.6917603015899658,
0.5897377729415894,
-0.5527322292327881,
-0.32496368885040283,
-0.9018886685371399,
-0.23769381642341614,
1.11714506149292,
0.6635611057281494,
-0.3200853765010834,
0.33892741799354553,
0.018948104232549667,
0.290404349565506,
0.47286227345466614,
-1.037239670753479,
-0.013075992465019226,
-0.6079689264297485,
-0.11842144280672073,
-0.7013968825340271,
0.6687551736831665,
0.13944043219089508,
0.0841810554265976,
0.28606173396110535,
0.49178993701934814,
0.09205269813537598,
-0.46560442447662354,
0.1558779627084732,
-0.2695000469684601,
-0.18887007236480713,
-0.40322041511535645,
0.4188113808631897,
-0.5700927376747131,
-0.009568730369210243,
0.20350395143032074,
0.5155393481254578,
0.24698399007320404,
-0.23862744867801666,
0.681736946105957,
-0.6003935933113098,
-0.14706845581531525,
-0.06805066764354706,
-0.24476251006126404,
0.3164336383342743,
-0.023328544571995735,
-0.5522229075431824,
-0.7538213133811951,
-0.13743259012699127,
-0.0904277041554451,
-0.32589659094810486,
0.0422576442360878,
-0.017329078167676926,
-0.08199882507324219,
0.12158192694187164,
-0.0814729779958725,
-0.20171158015727997,
-0.11976279318332672,
0.04981299117207527
] |
HIV-1 particle assembly mediated by viral Gag protein occurs predominantly at plasma membrane. While colocalization of HIV-1 envelope with lipid rich microenvironment have been shown in T cells, the significance of viral proteins modulating envelope association in such microdomains in plasma membrane enriched in glycosylphosphatidylinositol-anchored proteins in primary CD4(+ )T cells that are natural targets of HIV-1 is poorly understood. Here we show that in primary CD4(+ )T cells that are natural targets of HIV-1 in vivo, Gag modulates HIV-1 envelope association with GM1 ganglioside and CD59 rich cellular compartments as well as with detergent resistant membranes. Our data strengthen evidence that Gag-Env interaction is important in envelope association with lipid rafts containing GPI-anchored proteins for efficient assembly onto mature virions resulting in productive infection of primary CD4(+ )T cells. | [
-0.016552012413740158,
0.005689449608325958,
-0.0072603789158165455,
0.01881001889705658,
0.014539231546223164,
0.005821017548441887,
0.011800023727118969,
-0.00495558138936758,
-0.013714455999433994,
-0.016621246933937073,
-0.017710953950881958,
0.0126097546890378,
-0.006676690652966499,
0.03819083422422409,
0.001148995477706194,
0.006848300341516733,
-0.02282513864338398,
-0.01080850139260292,
0.00823668111115694,
0.04223105311393738,
0.024174124002456665,
-0.016226911917328835,
0.011202337220311165,
-0.009135272353887558,
0.016536463052034378,
-0.00313414353877306,
0.019799336791038513,
-0.015888433903455734,
-0.022625405341386795,
-0.014588641002774239,
0.013249947689473629,
0.011830136179924011,
0.014373705722391605,
-0.03213461488485336,
-0.015351259149610996,
-0.016898473724722862,
-0.005494038108736277,
0.02606084942817688,
0.015241595916450024,
-0.00452237855643034,
0.02685234695672989,
-0.01042418647557497,
0.005782699212431908,
-0.005330932792276144,
-0.008777089416980743,
-0.00033105292823165655,
-0.004228308796882629,
0.04077059030532837,
-0.007186911068856716,
0.0018849450862035155,
-0.001508686924353242,
-0.014956988394260406,
-0.004850814118981361,
-0.0017016860656440258,
-0.007185252383351326,
0.0015975665301084518,
0.01905917376279831,
-0.020343119278550148,
-0.00660889595746994,
0.03521218150854111,
0.009708588011562824,
-0.01034301146864891,
0.004184217657893896,
-0.006150503177195787,
-0.010636440478265285,
-0.06617666035890579,
0.012430759146809578,
-0.01235300675034523,
0.007044287398457527,
0.00937946792691946,
0.021660393103957176,
0.00511025357991457,
0.012962598353624344,
0.0262099988758564,
-0.01452407706528902,
-0.017343614250421524,
-0.010791176930069923,
0.013876281678676605,
-0.022030910477042198,
0.03594515472650528,
0.007835671305656433,
-0.001525303814560175,
-0.01683804765343666,
0.023330029100179672,
0.0035966006107628345,
0.0022616805508732796,
-0.016166381537914276,
0.014293684624135494,
0.0007581822574138641,
-0.02985321916639805,
0.014695195481181145,
-0.008157956413924694,
-0.04892983287572861,
-0.004986347630620003,
0.014176538214087486,
0.007989581674337387,
-0.02105209045112133,
-0.025227749720215797,
-0.01316910982131958,
0.004344934597611427,
-0.012658579275012016,
0.0035848733969032764,
0.024408778175711632,
0.016061481088399887,
0.012954194098711014,
0.004414713941514492,
0.024879856035113335,
0.0035156626254320145,
0.027756869792938232,
0.013529043644666672,
0.014676980674266815,
0.019009679555892944,
0.023464705795049667,
0.03627379238605499,
-0.0049978396855294704,
0.01245429739356041,
0.005689825862646103,
-0.009546689689159393,
0.012034403160214424,
-0.004581585060805082,
-0.013570577837526798,
-0.0012776241637766361,
0.00020587537437677383,
0.008586743846535683,
0.004901289474219084,
-0.026677872985601425,
0.02901020273566246,
0.011496862396597862,
0.008015165105462074,
0.008646777831017971,
-0.010024596005678177,
0.008311331272125244,
0.023967385292053223,
-0.03511472046375275,
-0.017824944108724594,
0.007298894226551056,
-0.0007249398622661829,
0.02056371606886387,
0.00500459736213088,
-0.013431956991553307,
-0.001865654718130827,
0.013570081442594528,
0.004955730400979519,
0.020106442272663116,
-0.00792481005191803,
0.009052639827132225,
-0.00978364609181881,
-0.0062002320773899555,
0.009100145660340786,
-0.04110093042254448,
0.01811065711081028,
0.007625557482242584,
0.004867333918809891,
-0.014323272742331028,
-0.0016697109676897526,
-0.00897141546010971,
-0.0029539410024881363,
-0.011933157220482826,
-0.00623680092394352,
-0.003644268261268735,
-0.009943339973688126,
-0.040254246443510056,
0.033422403037548065,
0.011623790487647057,
0.021611802279949188,
-0.003356394823640585,
-0.01484686229377985,
-0.02614426612854004,
0.0013679461553692818,
0.005395350977778435,
-0.012696763500571251,
0.010828934609889984,
0.002288254676386714,
0.007154145278036594,
-0.009489214047789574,
0.0027407468296587467,
0.02407919615507126,
0.005819236859679222,
-0.014437099918723106,
0.06601913273334503,
-0.013917203061282635,
0.020865364000201225,
-0.020691758021712303,
-0.03944949805736542,
-0.006873806938529015,
0.012910990975797176,
-0.03195498138666153,
-0.005643286742269993,
-0.0020228943321853876,
0.004348813556134701,
0.01306691113859415,
-0.03336544707417488,
0.0006501553580164909,
-0.012502973899245262,
0.01063602976500988,
0.0023441724479198456,
0.017528962343931198,
0.004388795234262943,
0.030006516724824905,
-0.04259433597326279,
0.011860395781695843,
-0.010437212884426117,
-0.008021362125873566,
-0.004037726204842329,
-0.03418427333235741,
0.005169127602130175,
-0.002942882478237152,
-0.007154408842325211,
-0.015600010752677917,
0.024127162992954254,
0.050695836544036865,
0.018824197351932526,
-0.01831464096903801,
0.002209065482020378,
-0.019894126802682877,
-0.0035037179477512836,
-0.0136550422757864,
0.017649080604314804,
-0.010349090211093426,
-0.0137421153485775,
-0.004889009520411491,
0.01806652545928955,
-0.03014283999800682,
0.004516766406595707,
0.005628441460430622,
-0.030757348984479904,
-0.004819921217858791,
0.010596709325909615,
-0.0038239439018070698,
0.013450246304273605,
-0.011897065676748753,
-0.027845069766044617,
-0.015453408472239971,
0.01772436313331127,
0.04566974937915802,
-0.04162905365228653,
0.01790667325258255,
-0.0026991302147507668,
0.028980813920497894,
-0.01367601752281189,
-0.004501679912209511,
-0.03387894853949547,
0.023704376071691513,
-0.039744287729263306,
0.015793273225426674,
0.025203809142112732,
0.02273113839328289,
0.016919303685426712,
-0.02849557437002659,
-0.030128171667456627,
0.011593938805162907,
-0.010499918833374977,
-0.00005423557013273239,
-0.041452549397945404,
0.03245193511247635,
-0.00196858961135149,
0.02686932124197483,
-0.021533438935875893,
0.027756277471780777,
-0.039155054837465286,
0.0060535455122590065,
0.006564320530742407,
0.007217185106128454,
-0.00874507799744606,
-0.0018592337146401405,
0.023476002737879753,
0.0030189165845513344,
0.0071531194262206554,
-0.028483707457780838,
0.005451971665024757,
0.01130037009716034,
0.004056846257299185,
0.012915345840156078,
-0.08076866716146469,
-0.02557823807001114,
-0.0036174841225147247,
0.009279396384954453,
0.00024623979697935283,
-0.025300610810518265,
-0.0004361881874501705,
-0.007521910592913628,
-0.009852452203631401,
-0.02094236947596073,
-0.0031623877584934235,
0.020648516714572906,
-0.003785116830840707,
-0.05536612868309021,
0.021097607910633087,
-0.005196124315261841,
0.022022131830453873,
-0.01778518781065941,
0.00456321332603693,
-0.020948123186826706,
0.010870955884456635,
0.006544667296111584,
0.03352734446525574,
0.001415509032085538,
-0.012851649895310402,
0.025483038276433945,
0.009661903604865074,
0.013049006462097168,
-0.001750231720507145,
-0.006002428010106087,
-0.017997026443481445,
-0.007544454652816057,
0.050281211733818054,
-0.02140546217560768,
0.03709005191922188,
-0.011459235101938248,
-0.005969493184238672,
0.014525864273309708,
-0.02470278926193714,
0.006889662705361843,
-0.02261706069111824,
0.0039186845533549786,
0.011385277844965458,
0.004351623356342316,
0.013365347869694233,
0.0025012195110321045,
-0.0036659836769104004,
-0.00212846789509058,
0.020151961594820023,
0.015714680776000023,
0.011191741563379765,
0.013343049213290215,
0.017261261120438576,
0.02790084108710289,
-0.0037062657065689564,
-0.01558624766767025,
-0.021893253549933434,
0.055428069084882736,
-0.0072019570507109165,
-0.008509757928550243,
0.001321437768638134,
-0.0002705371007323265,
0.010557055473327637,
0.04612988606095314,
-0.01735030487179756,
0.033407557755708694,
-0.00029619596898555756,
0.010135618969798088,
0.0005991245852783322,
-0.011388394981622696,
-0.00006200931966304779,
0.041090480983257294,
0.000046634115278720856,
-0.010511210188269615,
-0.01872554048895836,
-0.0036412833724170923,
-0.0164526104927063,
-0.0119477529078722,
-0.004430138040333986,
-0.023463772609829903,
-0.0386640727519989,
0.0005630666855722666,
-0.0017886243294924498,
-0.013938143849372864,
0.002025279216468334,
0.004824995994567871,
0.004578427877277136,
0.04396041855216026,
0.013912256807088852,
-0.01665477454662323,
0.03591508790850639,
0.03302937373518944,
-0.009919954463839531,
0.013299443759024143,
-0.006311175413429737,
-0.03579835593700409,
0.007356169633567333,
0.02754667028784752,
0.018984582275152206,
0.009114671498537064,
-0.04720504581928253,
-0.018711082637310028,
-0.03377781808376312,
-0.006552760023623705,
-0.03209317475557327,
0.010762826539576054,
-0.005217726342380047,
0.008437169715762138,
0.010313719511032104,
0.003027942031621933,
-0.006642034277319908,
0.028631869703531265,
-0.012182584032416344,
0.008461852557957172,
0.010186323896050453,
0.004833436571061611,
0.008884407579898834,
0.006377453915774822,
0.07116125524044037,
-0.012205440551042557,
-0.006493182387202978,
-0.028019238263368607,
0.03206022083759308,
-0.024658512324094772,
-0.004268448334187269,
0.019837327301502228,
-0.026059947907924652,
0.035789407789707184,
0.015368077903985977,
-0.013354167342185974,
0.0016325663309544325,
-0.02381296455860138,
-0.010012079030275345,
0.013431357219815254,
-0.0024433303624391556,
-0.012496432289481163,
0.01781759411096573,
0.0027703179512172937,
-0.004826118238270283,
-0.010024609975516796,
0.016021277755498886,
-0.0106538450345397,
-0.012518943287432194,
-0.015431107953190804,
0.02644219622015953,
-0.0146196149289608,
-0.0462464801967144,
0.011393354274332523,
0.017598897218704224,
-0.020834777504205704,
-0.012551693245768547,
0.014531780034303665,
0.03566877171397209,
0.012936239130795002,
0.00262229866348207,
-0.01993115060031414,
-0.0042678480967879295,
-0.01601945236325264,
0.01687246933579445,
-0.011965712532401085,
-0.01644422672688961,
0.009029778651893139,
-0.0007956600748002529,
-0.029229408130049706,
0.021276891231536865,
-0.004342413507401943,
0.013050033710896969,
-0.001805970910936594,
-0.010858128778636456,
-0.011004932224750519,
0.01177030149847269,
0.04532681405544281,
0.012410604394972324,
0.0038899737410247326,
0.01656770519912243,
-0.004889694042503834,
-0.013829880394041538,
-0.020504377782344818,
-0.019712654873728752,
-0.009388561360538006,
-0.017372656613588333,
0.0030896002426743507,
0.02018362656235695,
-0.010288504883646965,
-0.021488547325134277,
0.007361108437180519,
-0.012000959366559982,
0.023916738107800484,
0.02469310536980629,
0.0011290675029158592,
-0.016500983387231827,
0.015406493097543716,
-0.032246366143226624,
-0.00777841079980135,
0.00010832748375833035,
-0.011910622008144855,
0.02246008813381195,
-0.019602224230766296,
0.006492139771580696,
-0.006213775835931301,
0.025813542306423187,
0.008174080401659012,
-0.002728741616010666,
0.008827912621200085,
-0.034231383353471756,
-0.07501880824565887,
-0.02867894060909748,
-0.019750546663999557,
-0.006838019005954266,
0.012051280587911606,
-0.010276934131979942,
-0.01949695125222206,
-0.00550591666251421,
-0.012613259255886078,
-0.014750372618436813,
-0.014039624482393265,
0.010777657851576805,
0.01783660054206848,
-0.007009331602603197,
0.01459390390664339,
0.013451188802719116,
-0.02925870195031166,
-0.02536821737885475,
-0.023732248693704605,
0.00917754229158163,
-0.025968920439481735,
0.0027906480245292187,
-0.03402388095855713,
-0.0014009694568812847,
0.00963645800948143,
-0.08007398992776871,
-0.0029439444188028574,
-0.005359378177672625,
-0.015701599419116974,
0.013527391478419304,
-0.018796950578689575,
0.0039073750376701355,
-0.024040140211582184,
-0.03133002296090126,
-0.015429308637976646,
0.01896648108959198,
0.003458363004028797,
-0.0005183257162570953,
-0.03844531998038292,
-0.029143940657377243,
-0.002913902048021555,
0.006608353927731514,
-0.018953360617160797,
0.0005154800601303577,
-0.023312527686357498,
-0.0013838924933224916,
0.033861659467220306,
-0.013615095987915993,
0.0020114299841225147,
-0.004129019100219011,
-0.018245484679937363,
-0.029154537245631218,
0.012141242623329163,
-0.0011272300034761429,
-0.014639323577284813,
0.004879000596702099,
0.017505334690213203,
-0.028042925521731377,
-0.04888908565044403,
-0.03089785762131214,
-0.026841901242733,
0.025209829211235046,
-0.004315848462283611,
0.03657487779855728,
-0.016009390354156494,
-0.010925475507974625,
0.008021175861358643,
-0.02419547364115715,
-0.0017586288740858436,
0.0023851552978157997,
0.003619431983679533,
0.008921883068978786,
-0.012501390650868416,
0.027819976210594177,
-0.01993522234261036,
0.001996664796024561,
-0.04465125501155853,
-0.00970214232802391,
0.01267966628074646,
0.01790732704102993,
-0.005187904462218285,
-0.001830295310355723,
0.025263037532567978,
0.02063509076833725,
0.0018868341576308012,
-0.005967426113784313,
0.02053982950747013,
-0.005141058005392551,
0.07098782062530518,
-0.009136663749814034,
0.017470575869083405,
-0.030570778995752335,
0.005449913442134857,
0.009583555161952972,
-0.015260009095072746,
0.01164303906261921,
-0.015708688646554947,
-0.02282525599002838,
0.006422190926969051,
-0.01336994580924511,
0.0008314230944961309,
0.013416707515716553,
-0.028842441737651825,
0.03876635432243347,
0.007707281969487667,
0.03239298611879349,
0.012585424818098545,
0.04836462438106537,
0.012556287460029125,
-0.006221228279173374,
-0.011083938181400299,
-0.011093193665146828,
0.03232652693986893,
0.0015536164864897728,
0.011377286165952682,
0.01064301934093237,
-0.038066983222961426,
-0.004320893436670303,
-0.010478056967258453,
-0.01440813671797514,
0.0015814794460311532,
0.0029140664264559746,
0.011720407754182816,
0.030793363228440285,
-0.030097167938947678,
0.011277047917246819,
-0.0001319290604442358,
0.037542808800935745,
-0.010114738717675209,
-0.004736783914268017,
-0.0017147823236882687,
-0.02332141622900963,
0.014166727662086487,
-0.04915769398212433,
0.014430996030569077,
0.0027013830840587616,
0.003139019478112459,
0.022984184324741364,
0.028756089508533478,
-0.0014296480221673846,
0.028097983449697495,
0.009863022714853287,
0.010442692786455154,
0.026191111654043198,
0.005793556571006775,
0.009918427094817162,
-0.013823181390762329,
0.0022416762076318264,
0.0160369835793972,
-0.021468089893460274,
0.03146472945809364,
-0.023121565580368042,
0.00880474504083395,
-0.011313825845718384,
0.03160036355257034,
-0.027671337127685547,
-0.017281390726566315,
0.013677380979061127,
0.010622654110193253,
-0.004903997294604778,
0.008323488757014275,
0.0052511305548250675,
0.010442202910780907,
0.03992420434951782,
0.010211467742919922,
-0.00043846340849995613,
0.0054657235741615295,
0.018302086740732193,
-0.013827135786414146,
-0.008273583836853504,
0.016091225668787956,
0.011650661006569862,
-0.016461126506328583,
0.016462458297610283,
0.012409636750817299,
-0.01314816065132618,
0.00457013538107276,
0.012228292413055897,
0.006493225693702698,
0.006082678213715553,
0.002302405424416065,
-0.0006959163583815098,
0.0093087675049901,
0.03586144372820854,
0.009641731157898903,
0.00652301125228405,
0.0020546787418425083,
-0.022959304973483086,
-0.0083885183557868,
-0.03129583224654198,
-0.013168715871870518,
0.04194595664739609,
-0.014979719184339046,
-0.0053011709824204445,
0.03158564865589142,
-0.002087208442389965,
0.021598495543003082,
0.006991065107285976,
0.029481930658221245,
-0.008947270922362804,
0.0019511538557708263,
0.03781910985708237,
0.011487586423754692,
0.021545402705669403,
-0.005473645403981209,
-0.009434283711016178,
-0.04561999440193176,
-0.01831391453742981,
-0.005140292923897505,
-0.01761704683303833,
-0.007409627549350262,
0.0290895514190197,
0.018279334530234337,
-0.005459911189973354,
-0.007948481477797031,
0.021413810551166534,
0.013410091400146484,
-0.0072876401245594025,
0.01616443134844303,
-0.024414848536252975,
-0.007385799661278725,
0.03471728414297104,
0.010333024896681309,
0.010252945125102997,
0.009802090935409069,
0.00827061291784048,
-0.00788206234574318,
-0.029988210648298264,
0.02016070857644081,
-0.022871866822242737,
0.0019823582842946053,
-0.009821235202252865,
0.00798776000738144,
-0.009952534921467304,
0.03829048573970795,
0.008778529241681099,
0.009554002434015274,
0.031916387379169464,
0.019115252420306206,
0.00036097923293709755,
-0.01062026433646679,
-0.007361611817032099,
-0.016283271834254265,
0.0030989234801381826,
0.006679059937596321,
-0.05489470809698105,
-0.010686220601201057,
-0.011046307161450386,
-0.026333745568990707,
0.013211650773882866,
-0.011214397847652435,
-0.0009659682400524616,
-0.02565578930079937,
0.040749043226242065,
0.0007610060274600983,
0.00464561115950346,
0.015524501912295818,
-0.010285357013344765,
0.03577084839344025,
-0.013957338407635689,
0.001231205416843295,
0.032177332788705826,
-0.0451313853263855,
-0.0014877798967063427,
-0.004113292321562767,
0.008651682175695896,
0.02180354669690132,
0.007121866103261709,
0.009833065792918205,
-0.00040387455374002457,
0.009023472666740417,
-0.008916035294532776,
-0.0005202982574701309,
-0.0042298645712435246,
-0.004523301497101784,
0.011662596836686134,
0.024164430797100067,
-0.0039048665203154087,
-0.011137650348246098,
-0.025111785158514977,
-0.012898512184619904,
0.014923554845154285,
-0.0022675981745123863,
0.013348879292607307,
0.005718730390071869,
-0.001505471533164382,
0.009748812764883041,
0.01356230117380619,
-0.006929658353328705,
-0.014076155610382557
] | [
-0.2196463793516159,
0.0747162252664566,
0.004200713708996773,
-0.10645747184753418,
-0.16526257991790771,
-0.13013829290866852,
0.20356276631355286,
-0.22300808131694794,
-0.199900820851326,
-0.7550115585327148,
0.3106953203678131,
-0.009638643823564053,
-0.943335235118866,
-0.2557292580604553,
-0.005491003859788179,
0.47565731406211853,
0.33635789155960083,
0.2612907290458679,
-0.393633097410202,
-0.5151711702346802,
0.10779144614934921,
-0.32136693596839905,
0.09538520127534866,
0.0006183544755913317,
0.7506308555603027,
-0.4197978377342224,
0.6356390714645386,
-0.035237863659858704,
0.8524523973464966,
-0.17056940495967865,
0.07632248103618622,
0.07348945736885071,
0.08871883153915405,
-0.11988452076911926,
-0.3662918210029602,
0.11305654793977737,
-0.6351401805877686,
0.4955330789089203,
0.17427606880664825,
-0.26368892192840576,
-0.2236817628145218,
-0.5439825057983398,
-0.6116977334022522,
0.39307093620300293,
0.09719774127006531,
-0.5295934677124023,
-1.2339956760406494,
0.817279040813446,
-0.29868265986442566,
-0.19052653014659882,
-0.04499267786741257,
0.2571640610694885,
0.28897517919540405,
0.31897851824760437,
0.5090342164039612,
0.06705095618963242,
-0.8414247035980225,
0.0757250189781189,
0.5003034472465515,
-0.2343096137046814,
0.2168579399585724,
0.11901599168777466,
-0.009100175462663174,
0.15447911620140076,
0.07615654915571213,
0.9362649917602539,
0.10514774918556213,
-0.20385049283504486,
-0.3447721004486084,
-0.43688705563545227,
-0.23469360172748566,
-0.41259387135505676,
-0.03803713247179985,
0.15960626304149628,
0.11415871977806091,
-0.06783188879489899,
-0.2489730566740036,
-0.5596083998680115,
0.05183548107743263,
0.2924289107322693,
-0.3189261853694916,
0.08193496614694595,
-0.07877270132303238,
-0.07219672203063965,
0.47950151562690735,
0.19942985475063324,
-0.03028937056660652,
0.40479519963264465,
-0.4419971704483032,
0.287454754114151,
-0.307718962430954,
-0.10645844787359238,
0.18556185066699982,
0.14152802526950836,
0.2047743946313858,
0.5567167401313782,
-0.498006671667099,
0.49613672494888306,
0.18815156817436218,
-0.06904885172843933,
-0.29448816180229187,
0.31044456362724304,
-0.07763637602329254,
-0.22063322365283966,
-0.3662271201610565,
-0.23049360513687134,
0.04944844916462898,
-0.5815061926841736,
-0.7869514226913452,
-0.06912902742624283,
-0.6006484031677246,
-0.31796321272850037,
-0.4031684696674347,
-0.33084914088249207,
0.19099071621894836,
0.2716446816921234,
0.1442928910255432,
-0.7466350197792053,
-0.05047899857163429,
0.4178522229194641,
-0.5724489092826843,
1.3233081102371216,
-0.050028279423713684,
0.6313186883926392,
-0.052563559263944626,
-0.09077184647321701,
0.2138463258743286,
0.469625860452652,
-0.12485288083553314,
0.8227427005767822,
-0.09950266033411026,
1.123948335647583,
-0.43933016061782837,
0.1330217719078064,
0.16735535860061646,
-0.11248265951871872,
0.2091202735900879,
0.4694731831550598,
-0.0659821406006813,
-0.3654254078865051,
-0.5420233607292175,
-0.10691896080970764,
0.015687625855207443,
0.10774566978216171,
-0.22329750657081604,
-0.1270139366388321,
-0.14479228854179382,
-0.009381880983710289,
-0.06931691616773605,
-0.47296056151390076,
0.027800943702459335,
-0.4752312898635864,
-0.4281340539455414,
0.15752959251403809,
0.1012459322810173,
0.4352937638759613,
0.11179982125759125,
0.513309121131897,
-0.16293048858642578,
0.5077736377716064,
-0.0913265198469162,
0.12875224649906158,
-0.2880302965641022,
0.1287786066532135,
0.34279948472976685,
0.1116308942437172,
0.5657527446746826,
0.08972212672233582,
0.5169582962989807,
-0.2625495493412018,
-0.18400481343269348,
-0.6418589353561401,
-0.356295108795166,
-0.3208477199077606,
-0.3440195918083191,
-0.36481621861457825,
0.4004653990268707,
-0.10946237295866013,
0.0005477882223203778,
-0.24550819396972656,
-0.7101038098335266,
0.1835716813802719,
-0.23429648578166962,
-0.381481409072876,
0.41834506392478943,
0.3256358206272125,
0.5399830341339111,
0.3388773202896118,
-0.2834172248840332,
-0.24714580178260803,
0.46638113260269165,
0.3553485870361328,
0.6964476108551025,
-0.5714331269264221,
1.4336670637130737,
-0.07560889422893524,
-0.35004672408103943,
1.3641470670700073,
0.36368852853775024,
0.1373567134141922,
0.3383721709251404,
0.14369450509548187,
0.5687351822853088,
-0.5658462643623352,
-0.2949610650539398,
0.07421645522117615,
-0.27351295948028564,
-0.1470750868320465,
0.009722155518829823,
0.0740990862250328,
0.4042671024799347,
-0.14938421547412872,
-0.14624521136283875,
-0.439341276884079,
0.3603144884109497,
-0.1352144479751587,
0.05615992471575737,
-0.378580778837204,
-0.3287253975868225,
0.06915789842605591,
0.3244166970252991,
-0.8433506488800049,
0.6546551585197449,
0.9945632815361023,
-0.02244979701936245,
0.6254825592041016,
0.3645009398460388,
0.027282536029815674,
0.8753220438957214,
0.010856764391064644,
-0.08308503776788712,
-0.3768126964569092,
0.5981160998344421,
-0.47243139147758484,
-0.41244199872016907,
0.20206336677074432,
0.37815171480178833,
-0.038247331976890564,
0.19145339727401733,
0.48667287826538086,
0.3671600818634033,
0.83038330078125,
-0.8102425932884216,
-0.22265975177288055,
-0.14692769944667816,
-0.502959668636322,
-0.35774683952331543,
-0.020322030410170555,
-0.6693325042724609,
-0.11509955674409866,
-0.11264429241418839,
0.3134607970714569,
0.25775864720344543,
-0.3684154450893402,
0.3910825252532959,
0.18850618600845337,
-0.5555939674377441,
-0.08909997344017029,
0.4471226632595062,
-0.23420719802379608,
-0.0517793670296669,
-0.15679538249969482,
-0.05142934247851372,
0.6967300176620483,
0.030096959322690964,
-0.3624880313873291,
-0.3434727191925049,
0.13747872412204742,
0.7277798652648926,
0.8377807140350342,
1.0772593021392822,
0.08699939399957657,
-0.44079676270484924,
-0.16787107288837433,
0.40068700909614563,
-0.2622556984424591,
-0.00843595527112484,
0.9774194359779358,
-0.14369800686836243,
-0.5407309532165527,
0.2940185070037842,
0.1712825745344162,
0.7593910694122314,
-0.20325729250907898,
-0.19280241429805756,
-0.16470877826213837,
-0.4994181990623474,
-0.30929267406463623,
-0.5716618299484253,
-0.4596589505672455,
-0.10777818411588669,
0.42309561371803284,
-0.44442757964134216,
-0.37410056591033936,
0.17637348175048828,
0.5732424259185791,
-0.1450856626033783,
0.11945375800132751,
0.613783061504364,
-0.017405057325959206,
-0.08857227116823196,
0.6361610889434814,
-0.721925675868988,
-0.034986432641744614,
-0.3572637438774109,
0.22582747042179108,
-0.3718163073062897,
-0.08348044753074646,
-5.703986167907715,
0.18475399911403656,
0.14150972664356232,
-0.0820934846997261,
-0.2934621572494507,
-0.4101760983467102,
1.0098556280136108,
-0.06014152988791466,
0.5003690719604492,
0.09256252646446228,
0.23074759542942047,
0.2821514308452606,
-0.34701618552207947,
-0.24541622400283813,
-0.18469029664993286,
0.1292731612920761,
0.09513594210147858,
0.015622678212821484,
0.7751577496528625,
0.04995958134531975,
0.18339507281780243,
-0.24108457565307617,
0.13235995173454285,
-0.01681690849363804,
0.14714471995830536,
-0.23944354057312012,
-0.9183262586593628,
0.3794052302837372,
0.1388566493988037,
0.030268404632806778,
0.2720186710357666,
-0.730291485786438,
-0.07096967101097107,
-0.43755388259887695,
0.2551139295101166,
0.1767861694097519,
0.5442469120025635,
-0.17132604122161865,
-0.03518928587436676,
-0.5210878252983093,
0.5190201997756958,
-0.12549130618572235,
-0.11264997720718384,
-0.12102936208248138,
0.08002280443906784,
-0.17018432915210724,
-0.007099526934325695,
0.018394330516457558,
-0.3539550304412842,
0.7519509196281433,
-0.1526888757944107,
-0.30954718589782715,
-0.02740301378071308,
0.6035116314888,
0.616895318031311,
-0.007923056371510029,
-0.3408903181552887,
0.05960901454091072,
-0.8408524990081787,
0.06260443478822708,
-0.49180278182029724,
-0.20463153719902039,
-0.5299302935600281,
-0.9965084195137024,
0.5504283905029297,
0.2727493643760681,
-0.712604820728302,
-0.043100837618112564,
0.6912329196929932,
-0.03360887989401817,
-0.2298915982246399,
0.045884642750024796,
0.0392024889588356,
-0.5893591046333313,
0.5632308721542358,
-0.2565086781978607,
0.06928000599145889,
0.29852187633514404,
-0.08917485177516937,
-0.4212197959423065,
-0.5387102961540222,
-0.4085974097251892,
-0.40900927782058716,
0.018941929563879967,
0.3685808479785919,
-0.13918167352676392,
-0.16919046640396118,
0.0342092290520668,
-0.306242972612381,
0.1956290304660797,
0.7325672507286072,
-0.27185672521591187,
0.03938668593764305,
0.7479942440986633,
-0.029882684350013733,
0.04246385768055916,
0.058201804757118225,
0.3666483163833618,
0.6866341829299927,
-0.4695761501789093,
0.9429765939712524,
-0.29891273379325867,
-0.6110059022903442,
-0.6385916471481323,
-0.2865488827228546,
0.22135798633098602,
-0.8286943435668945,
-0.04347352311015129,
1.0365486145019531,
-0.8083627820014954,
0.11782676726579666,
-0.08485482633113861,
-0.6789100170135498,
-0.03732900321483612,
0.7694420218467712,
-0.03548911213874817,
-0.12525665760040283,
0.21258407831192017,
0.6631372570991516,
-0.45318272709846497,
0.2845163941383362,
0.27962610125541687,
-0.40016958117485046,
0.12139590829610825,
-0.07611951977014542,
0.15346381068229675,
0.13174772262573242,
0.7077280282974243,
-0.897563099861145,
-0.38224175572395325,
0.38681870698928833,
0.20984260737895966,
-0.5607962012290955,
-0.15922337770462036,
0.43129411339759827,
-0.31026872992515564,
-0.3670884668827057,
-0.09677514433860779,
0.35736867785453796,
-0.10533508658409119,
0.36660701036453247,
-0.35371309518814087,
0.10766497999429703,
0.1928214281797409,
0.08972123265266418,
-0.03037373349070549,
-0.17079602181911469,
0.034072183072566986,
-0.6786656975746155,
-0.5116176009178162,
0.1902998834848404,
-0.1882762908935547,
0.1817384958267212,
0.10221156477928162,
-0.42330116033554077,
0.7604748010635376,
0.7840127348899841,
0.250830739736557,
0.07664836943149567,
-0.431511789560318,
0.560343325138092,
0.25277179479599,
-0.3774741291999817,
0.4467949867248535,
-0.24765123426914215,
-0.12090947479009628,
0.014390134252607822,
-0.128366157412529,
-0.06618374586105347,
0.20823214948177338,
-0.23309773206710815,
-0.6242878437042236,
-0.578018069267273,
-0.34931591153144836,
0.03764660283923149,
-0.07220566272735596,
-0.677636981010437,
0.3702232837677002,
-0.02004970796406269,
0.08654317259788513,
0.022275274619460106,
-0.8422024846076965,
-0.36625587940216064,
0.49550238251686096,
0.5621150732040405,
0.3134835362434387,
-0.2572537958621979,
-0.19026699662208557,
-0.6512218117713928,
-0.40221893787384033,
0.28025397658348083,
0.3494662344455719,
0.3482118546962738,
-0.22208960354328156,
0.32641783356666565,
-0.24038949608802795,
-0.09988994896411896,
0.5441421866416931,
0.03955651819705963,
-0.4911346435546875,
0.1719948798418045,
0.2352162003517151,
-0.18674398958683014,
0.6231736540794373,
-0.1627301126718521,
0.2305448353290558,
-0.3691979944705963,
-0.05759216845035553,
0.11330022662878036,
-0.1169186532497406,
-0.046121541410684586,
-0.8479377031326294,
0.3822939991950989,
0.6781672239303589,
-0.05224450305104256,
-0.04677606746554375,
-0.023041289299726486,
0.038614001125097275,
0.08488193154335022,
0.37134042382240295,
-0.157928004860878,
-0.15406061708927155,
-0.10896500200033188,
-0.2342023402452469,
-0.07918987423181534,
0.5050250291824341,
0.7088831067085266,
-0.8141178488731384,
-0.01428789459168911,
0.20524197816848755,
0.47466784715652466,
-0.15663571655750275,
0.052628032863140106,
-0.16988468170166016,
-0.41429683566093445,
-0.42596179246902466,
0.10496824979782104,
0.1488269567489624,
-0.022350238636136055,
0.7310062646865845,
0.39272814989089966,
0.44425827264785767,
-0.6338794231414795,
-0.2768878936767578,
0.14737002551555634,
0.7906253337860107,
0.5490822196006775,
-0.5918742418289185,
-0.6008577346801758,
0.3698347806930542,
-0.14579957723617554,
-0.05260578170418739,
0.09566338360309601,
0.5562810897827148,
1.2178207635879517,
-0.13958589732646942,
-0.34292471408843994,
-0.430703729391098,
-0.09104613959789276,
-0.12106148898601532,
-0.1875249743461609,
-0.009397105313837528,
-0.3938697278499603,
-0.38477516174316406,
-0.01849457435309887,
-0.03243342787027359,
-0.12074769288301468,
-0.18432916700839996,
0.21551842987537384,
0.01403134223073721,
-0.6513813734054565,
-0.6448821425437927,
0.874652087688446,
0.3321521580219269,
-0.31023406982421875,
0.11464409530162811,
-0.11978743970394135,
0.46599000692367554,
-0.05968739837408066,
0.31431126594543457,
-0.20806503295898438,
-0.9257842302322388,
0.7750388979911804,
-0.5681084394454956,
0.4170090854167938,
-0.6376386284828186,
-0.2623664438724518,
-0.39440006017684937,
0.39039626717567444,
-0.1883055567741394,
-0.20649607479572296,
-0.17791929841041565,
-0.9235038757324219,
-0.38423532247543335,
-0.021571144461631775,
0.577366054058075,
0.33116358518600464,
0.20140786468982697,
0.13298816978931427,
0.052202556282281876,
-0.47128182649612427,
0.593218982219696,
0.2523288428783417,
-0.20775000751018524,
-0.22005319595336914,
0.32411253452301025,
0.11703294515609741,
0.2815159261226654,
-0.27355003356933594,
-0.4894260764122009,
-0.09720243513584137,
0.0011860973900184035,
0.6196686029434204,
-0.14172251522541046,
-0.8778902292251587,
0.02594420127570629,
0.24945521354675293,
-0.25772392749786377,
0.06402304768562317,
-0.010680840350687504,
0.3081478774547577,
0.5561569333076477,
0.25881555676460266,
-0.18393729627132416,
-0.12143591791391373,
0.5955573320388794,
-0.016357144340872765,
-0.15628227591514587,
-0.25167420506477356,
0.32585349678993225,
0.8265393376350403,
-0.025989342480897903,
-0.1856076419353485,
0.3635921776294708,
0.4266264736652374,
0.17607077956199646,
0.13659381866455078,
-0.23277805745601654,
-0.24637798964977264,
0.010013430379331112,
0.6108484864234924,
0.4517296552658081,
-0.2567742168903351,
-0.3806927502155304,
0.21237510442733765,
-0.12145289778709412,
0.015526645816862583,
0.1310664862394333,
0.1166829988360405,
0.45611342787742615,
0.1644544005393982,
-0.5770729184150696,
-0.43880754709243774,
0.17533144354820251,
-0.7498414516448975,
-0.26471057534217834,
0.7308186888694763,
-0.29507264494895935,
-0.7906318306922913,
-0.15284542739391327,
0.03590979054570198,
-0.07394906133413315,
0.4964829683303833,
0.894318163394928,
-0.0009462545276619494,
0.24402953684329987,
0.3546457290649414,
0.12660913169384003,
0.10358072072267532,
0.018652521073818207,
0.054708331823349,
-0.13274091482162476,
0.03862731158733368,
0.4541252553462982,
-0.05518316105008125,
-0.35494929552078247,
-0.015321772545576096,
-0.1992189586162567,
-0.35364091396331787,
0.2734324634075165,
-0.033660680055618286,
0.03321079537272453,
0.07379164546728134,
-0.9461170434951782,
-0.4110039472579956,
-0.3211817741394043,
-0.16655820608139038,
-0.13727593421936035,
-0.27273374795913696,
0.38754066824913025,
0.32897958159446716,
-0.6652171015739441,
0.13211190700531006,
0.056233879178762436,
0.010309020057320595,
0.3396526575088501,
-0.30377668142318726,
0.437703013420105,
0.14554455876350403,
0.47793713212013245,
-0.28776514530181885,
0.7693889141082764,
-0.5392253994941711,
0.3871997594833374,
-0.4779517948627472,
0.8609184622764587,
-0.6348363757133484,
-0.44116097688674927,
-0.48625725507736206,
-0.3350141942501068,
1.4518648386001587,
0.6907916069030762,
-0.4024527966976166,
-0.10466863214969635,
0.30291417241096497,
0.6589266657829285,
0.034987982362508774,
-0.5061116814613342,
-0.3211846649646759,
-0.13780106604099274,
-0.432107150554657,
-0.486754447221756,
0.19849856197834015,
0.3521020710468292,
-0.11398961395025253,
-0.4385184049606323,
0.4344326853752136,
0.2687026858329773,
-0.35235726833343506,
0.30161693692207336,
0.004060856066644192,
0.00484213512390852,
-0.514453649520874,
0.24566791951656342,
-0.4306298494338989,
0.12613381445407867,
-0.3849268853664398,
0.09463909268379211,
0.16195359826087952,
0.31878143548965454,
0.4067462682723999,
-0.2552933990955353,
-0.07084355503320694,
0.3169248402118683,
-0.33102741837501526,
-0.45995447039604187,
0.0310813058167696,
-0.7050524950027466,
-0.7319818139076233,
0.2615525722503662,
0.3027232587337494,
-0.4779810905456543,
-0.07297951728105545,
0.023855730891227722,
-0.07033885270357132,
0.16306234896183014,
0.24026285111904144,
-0.526465117931366,
-0.14701028168201447,
0.1880517303943634
] |
The influenza A nucleoprotein (NP) is an attractive target for avian flu vaccine development because of its high conversancy in the evolutionary chain of the virus. Here we identified two novel HLA-A*0201 restricted NP epitopes, named H5N1 NP373-381 AMDSNTLEL (NP373) and NP458-466 FQGRGVFEL (NP458), using computational bioinformatic analysis. The NP peptides showed a high binding affinity to HLA-A*0201 on T2 cells, and were able to induce the activation of the cytotoxic T cells in the human peripheral blood mononuclear cells. We examined the potential of using NP373 and NP458 peptide sequences supplemented with a single-chain trimer as potential DNA vaccine candidates in an HHD transgenic mouse model. A gene gun delivery system was used for administrating the vaccine candidates into the animals. The results from cytotoxicity and ELISPOT assays indicated that a significant amount of IFN-γ was secreted by the T cells of the vaccinated mice, and the T cells were able to eliminate the corresponding peptide-loaded T2 cells. The discovery of these novel immunogenic NP peptides provides valuable information for avian flu vaccine design and construction. | [
0.009166005998849869,
0.008680582046508789,
-0.002359038218855858,
0.015154717490077019,
0.002228635363280773,
0.0004973325412720442,
0.007273721508681774,
0.021400734782218933,
-0.007286280393600464,
-0.020978815853595734,
-0.0075009665451943874,
0.003509397618472576,
-0.012645164504647255,
0.010552560910582542,
0.005174488760530949,
-0.0029022651724517345,
-0.017939399927854538,
0.03397415578365326,
0.011169534176588058,
0.006463833153247833,
-0.039897553622722626,
-0.0038311025127768517,
0.007888310588896275,
0.007540982216596603,
-0.005010847467929125,
0.011622272431850433,
-0.0036691019777208567,
-0.004030829761177301,
0.007409755140542984,
-0.00609238725155592,
0.017965910956263542,
-0.007980868220329285,
0.02430787868797779,
-0.012550135143101215,
-0.0025563028175383806,
0.02294265851378441,
-0.004043698776513338,
0.01831097900867462,
0.025959134101867676,
-0.0034990503918379545,
-0.0006525265052914619,
-0.014424308203160763,
0.0000437319977208972,
-0.02031721919775009,
-0.005237724166363478,
0.0160693172365427,
-0.0017180494032800198,
0.010766565799713135,
0.00629802793264389,
0.005541857331991196,
-0.001038348418660462,
-0.0038028715644031763,
-0.017077824100852013,
0.02216070145368576,
-0.004080452956259251,
-0.002446363680064678,
0.012600857764482498,
-0.0099194860085845,
-0.03276418149471283,
-0.007789859548211098,
0.010967142879962921,
-0.010572187602519989,
0.007776921149343252,
-0.00428773183375597,
0.012607032433152199,
-0.06767471134662628,
0.03458623215556145,
0.011662628501653671,
0.003975215367972851,
-0.004641956649720669,
0.028035413473844528,
0.009145701304078102,
0.003257984993979335,
-0.005252062808722258,
-0.010190748609602451,
0.011614096350967884,
-0.006150050554424524,
0.007712663151323795,
-0.0009414942469447851,
0.015970606356859207,
-0.026294313371181488,
-0.0016387717332690954,
0.010337214916944504,
0.005699761211872101,
-0.0041121309623122215,
0.004150919150561094,
-0.021737154573202133,
0.00750978896394372,
-0.0004338186699897051,
-0.0022850704845041037,
0.01282776053994894,
0.009374219924211502,
-0.012697434052824974,
-0.0038344322238117456,
-0.0018948698416352272,
0.0035997782833874226,
-0.013206618838012218,
-0.005433961283415556,
0.00312327453866601,
-0.007827198132872581,
-0.011768362484872341,
0.024341201409697533,
0.006350426934659481,
0.004911388270556927,
-0.0012875464744865894,
0.008122382685542107,
0.0007371553219854832,
0.025260835886001587,
0.03292347490787506,
0.006192391738295555,
-0.003351881867274642,
-0.007202955428510904,
-0.022558821365237236,
0.008568297140300274,
-0.0042160931043326855,
0.01569659635424614,
-0.00826039258390665,
0.027610816061496735,
0.011431938968598843,
0.01785453036427498,
-0.008581689558923244,
-0.0027453904040157795,
0.0048363287933170795,
0.008743491023778915,
0.009480712935328484,
-0.013790035620331764,
0.010100271552801132,
-0.003889269195497036,
0.006587650161236525,
0.001774938078597188,
-0.00844583474099636,
0.015399265103042126,
-0.013800119049847126,
0.005890230648219585,
-0.004311936907470226,
0.002224529627710581,
0.013918774202466011,
-0.0109479408711195,
-0.005853990558534861,
-0.014687282964587212,
-0.0016466518864035606,
0.003726324997842312,
-0.0035276003181934357,
0.014914389699697495,
-0.004830482415854931,
0.010652776807546616,
0.013128549791872501,
0.00385615904815495,
-0.0017026928253471851,
0.01084451749920845,
-0.003425376722589135,
0.009315281175076962,
-0.0004009814001619816,
-0.009634505957365036,
0.041253432631492615,
0.021366920322179794,
-0.004394823685288429,
0.02150627411901951,
-0.005803280044347048,
0.012716667726635933,
-0.0003720461390912533,
-0.021026577800512314,
0.008510816842317581,
0.007097392342984676,
0.01068846881389618,
0.007172367535531521,
0.023355159908533096,
-0.007983194664120674,
-0.01676662266254425,
0.004654443822801113,
-0.0013116666814312339,
0.025857366621494293,
0.0006161155179142952,
0.008902586996555328,
0.013167522847652435,
-0.010052619501948357,
0.016717785969376564,
0.005491576157510281,
-0.009936703369021416,
0.06716153025627136,
0.004085063934326172,
-0.003884935053065419,
0.01911069080233574,
0.018149863928556442,
0.01396897528320551,
-0.018313448876142502,
-0.0009822994470596313,
-0.0011065058642998338,
0.01264909002929926,
0.0012654047459363937,
-0.00512784393504262,
0.0009565592044964433,
-0.004311795812100172,
0.012130850926041603,
-0.00461552944034338,
0.0021543956827372313,
-0.009537787176668644,
0.001728117698803544,
-0.009353268891572952,
-0.00040320586413145065,
0.040518730878829956,
-0.005159173626452684,
0.011934326961636543,
-0.0002606939524412155,
-0.015645764768123627,
0.008846525102853775,
-0.008347215130925179,
0.0017746060620993376,
-0.01028013788163662,
-0.004419464152306318,
0.01207006722688675,
-0.05308280512690544,
-0.02014021761715412,
-0.0005945886368863285,
0.002967210253700614,
0.0029663625173270702,
0.023701105266809464,
0.0075201671570539474,
0.00825509987771511,
-0.004896944388747215,
-0.0031809634529054165,
0.007364918477833271,
-0.023301828652620316,
-0.010910500772297382,
0.025064148008823395,
-0.005557266063988209,
0.015138687565922737,
0.0051291147246956825,
-0.0004722997546195984,
0.003727693110704422,
-0.013368895277380943,
-0.02537284977734089,
-0.012343536131083965,
0.008855978958308697,
-0.006305128801614046,
-0.0008874810300767422,
0.009622365236282349,
-0.019112803041934967,
-0.004613177850842476,
-0.007943416014313698,
-0.0003865170292556286,
0.007446929346770048,
0.01300753466784954,
-0.024178847670555115,
0.005423928145319223,
-0.028001420199871063,
0.01536670234054327,
-0.0029680761508643627,
-0.006037023384124041,
-0.0071225883439183235,
0.009226434864103794,
0.008048346266150475,
0.0016837206203490496,
-0.04518841579556465,
-0.00880704540759325,
0.010953588411211967,
0.008895997889339924,
-0.012045453302562237,
0.0205240361392498,
0.006518904119729996,
0.006443772464990616,
0.0066706156358122826,
0.0005706911906599998,
0.002410221379250288,
-0.030005354434251785,
0.034744322299957275,
-0.008254475891590118,
-0.0034041740000247955,
-0.017679914832115173,
0.012241721153259277,
0.007331949658691883,
0.001956741791218519,
-0.003579584416002035,
-0.08221250027418137,
-0.004636290017515421,
-0.00668292073532939,
-0.0073496806435287,
0.004800471477210522,
0.019574539735913277,
0.023788033053278923,
-0.0006627127877436578,
-0.01260579563677311,
0.01242966577410698,
0.017392311245203018,
-0.011797476559877396,
-0.015474432148039341,
0.012516333721578121,
0.003982993774116039,
-0.0023594850208610296,
0.007289658300578594,
0.020389938727021217,
-0.01717476174235344,
-0.03366238996386528,
0.01386362686753273,
0.0008143731392920017,
0.01019914261996746,
-0.003749383380636573,
-0.015815887600183487,
0.00415775366127491,
-0.0077012674883008,
0.01045941561460495,
-0.0009744709823280573,
0.0012540856841951609,
0.000282930675894022,
-0.0036849440075457096,
0.01727023907005787,
-0.010982184670865536,
0.029983587563037872,
0.01316563505679369,
-0.009977934882044792,
-0.015195895917713642,
0.0007717898115515709,
0.010322077199816704,
-0.012588853016495705,
0.01016964577138424,
0.0006955633871257305,
0.005497091915458441,
0.011644348502159119,
0.003844739170745015,
-0.0012576412409543991,
0.014964303001761436,
0.015904482454061508,
-0.014273697510361671,
0.007645902223885059,
0.007634143345057964,
0.01296234130859375,
0.016975754871964455,
-0.007295382674783468,
0.03138417750597,
0.0010003792122006416,
0.0038658850826323032,
-0.011521665379405022,
0.0008665636414662004,
-0.019619371742010117,
0.03893858194351196,
0.012237276881933212,
-0.003781595965847373,
-0.0167697761207819,
-0.0024671535938978195,
0.010661261156201363,
-0.007899515330791473,
-0.022628867998719215,
0.025443460792303085,
0.021590370684862137,
0.0019406401552259922,
-0.01314566470682621,
-0.006324027664959431,
-0.011081247590482235,
-0.007310429587960243,
-0.007476862519979477,
-0.010018188506364822,
-0.002256147563457489,
-0.004617371596395969,
-0.009806638583540916,
0.003477710299193859,
-0.005913225933909416,
-0.013225486502051353,
-0.004441516473889351,
-0.010919150896370411,
0.005616816692054272,
-0.0008001781534403563,
0.013023186475038528,
-0.008695090189576149,
-0.0062282453291118145,
0.011495593935251236,
-0.003255918389186263,
0.007210347801446915,
-0.020401809364557266,
-0.011551829054951668,
-0.005216407123953104,
0.01610444486141205,
0.014086863026022911,
0.006842446513473988,
0.0020068928133696318,
-0.0029555107466876507,
0.004953267052769661,
-0.007163644768297672,
-0.043065693229436874,
0.008075730875134468,
0.010403118096292019,
-0.015809280797839165,
-0.01825343258678913,
0.002725382801145315,
0.0005180221050977707,
-0.0026671034283936024,
-0.001173437456600368,
-0.009806630201637745,
0.006739675998687744,
-0.007888305932283401,
-0.004522377625107765,
0.0038219778798520565,
0.07353909313678741,
0.003764630062505603,
-0.0013659950345754623,
-0.021619241684675217,
-0.014465664513409138,
-0.01656310260295868,
0.00418041693046689,
0.00811215490102768,
0.0030384559649974108,
-0.005191168747842312,
0.008510850369930267,
-0.01925741136074066,
0.0017703536432236433,
-0.0013618050143122673,
-0.01096515916287899,
-0.007180439308285713,
0.016823958605527878,
0.006369480397552252,
-0.012494830414652824,
0.016345979645848274,
-0.007716084364801645,
-0.006084839813411236,
-0.007188251242041588,
-0.0014087622985243797,
0.00018115597777068615,
0.008954199030995369,
0.028523201122879982,
-0.00996630359441042,
-0.003008565865457058,
0.008041519671678543,
-0.0070907557383179665,
-0.02143523469567299,
-0.008043503388762474,
-0.004459790885448456,
0.026636848226189613,
-0.0051322984509170055,
0.0141316968947649,
-0.00047028285916894674,
0.012671278789639473,
0.0015715090557932854,
-0.013777943328022957,
-0.012593213468790054,
0.023159828037023544,
0.006501489318907261,
-0.03818942606449127,
0.0006586839444935322,
-0.0038666648324579,
-0.006598575972020626,
-0.006764506921172142,
-0.006064661778509617,
-0.003084704512730241,
0.0021791064646095037,
0.0056503284722566605,
0.013451923616230488,
-0.0010643135756254196,
0.01710902526974678,
-0.0050338213331997395,
-0.010958361439406872,
-0.011845082975924015,
-0.003991767764091492,
-0.010219648480415344,
-0.014198195189237595,
0.013539057224988937,
-0.01181522011756897,
0.01239684410393238,
-0.020280320197343826,
-0.005019704345613718,
-0.006747649051249027,
-0.02037636935710907,
0.009223156608641148,
0.0002554433885961771,
0.007802257314324379,
0.0076870545744895935,
-0.025323057547211647,
-0.005885658785700798,
-0.009965803474187851,
-0.0029709869995713234,
0.006939121522009373,
0.003443591296672821,
-0.00772925466299057,
0.03357744961977005,
0.019594324752688408,
-0.0022432333789765835,
-0.01003099326044321,
-0.003731484990566969,
-0.02073143795132637,
-0.005547762382775545,
-0.07502578943967819,
-0.023856088519096375,
0.00839948933571577,
-0.0034743244759738445,
-0.003465685062110424,
0.015039687976241112,
-0.007959356531500816,
-0.004778152797371149,
-0.015092117711901665,
-0.0024049312341958284,
0.0035327300429344177,
-0.011495079845190048,
0.028856143355369568,
0.011584615334868431,
0.009497568942606449,
0.00029652751982212067,
0.005946051795035601,
0.009187431074678898,
0.007402702234685421,
-0.013333776965737343,
0.007049307227134705,
0.0011105230078101158,
-0.03640338033437729,
-0.004795217886567116,
-0.010769812390208244,
-0.08258700370788574,
-0.027877526357769966,
0.016685299575328827,
0.009403564035892487,
-0.01597616821527481,
0.004432125017046928,
0.009034402668476105,
-0.005368664860725403,
-0.028118830174207687,
-0.011910822242498398,
0.004532679915428162,
0.01156687829643488,
0.0031735054217278957,
-0.004040061496198177,
-0.007998994551599026,
-0.010251767933368683,
0.011474650353193283,
-0.0008423167746514082,
0.010714402422308922,
0.02177288755774498,
0.001882597804069519,
0.004246068187057972,
-0.005732489749789238,
-0.003598953830078244,
-0.013733209110796452,
-0.01538514532148838,
-0.020437072962522507,
0.012264281511306763,
-0.0016549250576645136,
-0.013720513321459293,
-0.01437097042798996,
-0.01932118646800518,
-0.008032048121094704,
0.006457292474806309,
-0.0018756603822112083,
-0.009514613077044487,
0.016451256349682808,
-0.018218228593468666,
0.017497530207037926,
-0.004863659851253033,
-0.0042058262042701244,
0.018157033249735832,
0.001644250936806202,
0.006095673888921738,
-0.00021956907585263252,
-0.006739034317433834,
0.00821048766374588,
-0.0026983332354575396,
0.0111432746052742,
0.011972887441515923,
0.0011741372290998697,
-0.020898569375276566,
0.011612046509981155,
-0.0006535211578011513,
-0.006081613712012768,
0.016266120597720146,
-0.0017769807018339634,
-0.012752169743180275,
-0.0004492797306738794,
0.006571792531758547,
-0.003771372139453888,
-0.0078036286868155,
0.020518921315670013,
0.0726776123046875,
-0.01351988036185503,
0.010833325795829296,
-0.02510761469602585,
-0.0015024954918771982,
0.0004780493618454784,
0.028356332331895828,
-0.008992364630103111,
-0.01660791039466858,
-0.007865569554269314,
0.030625369399785995,
-0.008535866625607014,
-0.004599052015691996,
0.008623309433460236,
-0.017972080036997795,
0.003927828278392553,
-0.003531242022290826,
-0.006084198132157326,
-0.020101934671401978,
0.01670614257454872,
0.001062597380951047,
0.004218334797769785,
-0.030682606622576714,
0.003467484377324581,
0.016054583713412285,
-0.0026751530822366476,
0.009042004123330116,
0.003604175988584757,
-0.019923390820622444,
0.01823381707072258,
0.012062250636518002,
0.0028820205479860306,
0.0020632389932870865,
0.0021796482615172863,
0.0189579576253891,
-0.004024857189506292,
-0.011766266077756882,
0.010848244652152061,
-0.006819121539592743,
-0.0025749937631189823,
0.01118522509932518,
0.009265958331525326,
-0.003257078118622303,
-0.0009279574733227491,
0.010477724485099316,
-0.0013019470497965813,
0.021714691072702408,
0.02243996597826481,
0.0029288744553923607,
0.008366583846509457,
0.026954814791679382,
-0.0025360938161611557,
0.008125197142362595,
-0.015883782878518105,
0.016645895317196846,
-0.004239389672875404,
-0.018771573901176453,
-0.0012083171168342233,
0.005352341569960117,
-0.006912319455295801,
0.023625573143363,
-0.011000368744134903,
0.02506658062338829,
-0.006620315369218588,
0.017043080180883408,
-0.010661032982170582,
-0.010352125391364098,
-0.02071305364370346,
-0.0034349700435996056,
0.00928403064608574,
0.005359075963497162,
0.013605481013655663,
0.007591206580400467,
0.0012128236703574657,
0.03227463737130165,
0.024166684597730637,
0.024829387664794922,
0.007723361719399691,
0.00910920463502407,
0.000051288632676005363,
-0.017299635335803032,
-0.0075465235859155655,
0.009518404491245747,
0.0236322283744812,
-0.01421779952943325,
0.013351017609238625,
0.009360797703266144,
0.009529865346848965,
-0.002149594947695732,
0.004772178828716278,
-0.01426691934466362,
0.006007140502333641,
0.00714314728975296,
0.008522058837115765,
0.0063372524455189705,
0.032273635268211365,
0.029065551236271858,
0.005172991193830967,
0.004320043604820967,
0.009354009293019772,
-0.0035976360086351633,
-0.01602647267282009,
-0.013513987883925438,
-0.021394498646259308,
-0.006005682982504368,
0.008634602651000023,
-0.004820784088224173,
-0.012724032625555992,
-0.012368221767246723,
-0.005189152434468269,
0.008770352229475975,
-0.004467955324798822,
0.021269340068101883,
0.007745707407593727,
0.009784523397684097,
0.0009846771135926247,
-0.016457252204418182,
0.009794463403522968,
-0.0035304324701428413,
-0.01196444034576416,
-0.01119490247219801,
0.012336080893874168,
0.0019246938172727823,
-0.0005301274359226227,
0.0029477542266249657,
-0.02256634831428528,
-0.005936012603342533,
0.017902474850416183,
-0.00569141423329711,
0.012234624475240707,
0.02578536421060562,
-0.01224728487432003,
-0.00837443396449089,
-0.0072327121160924435,
0.005360288545489311,
0.005477650091052055,
0.009134717285633087,
-0.006353060714900494,
0.007140342611819506,
0.007472793571650982,
0.003215649165213108,
-0.024649038910865784,
0.001774743665009737,
-0.0022457523737102747,
0.005813958588987589,
-0.018696855753660202,
-0.005803748965263367,
0.007851678878068924,
0.0010507788974791765,
0.004383711144328117,
0.012432684190571308,
0.0025462587364017963,
0.015662532299757004,
-0.008466613478958607,
0.013901309110224247,
0.01232987456023693,
-0.008383681997656822,
-0.0046250298619270325,
-0.00520477257668972,
0.005594928283244371,
0.02807391807436943,
0.007621281780302525,
0.014320055022835732,
-0.010623414069414139,
-0.019551238045096397,
0.006454075686633587,
0.01932491920888424,
0.022316019982099533,
-0.013421946205198765,
-0.004679294768720865,
0.013211386278271675,
-0.012659524567425251,
0.020488649606704712,
0.0075843012891709805,
-0.001653225626796484,
-0.0025838399305939674,
-0.013897805474698544,
0.010809442028403282,
-0.003016162198036909,
-0.017560599371790886,
0.00434221513569355,
-0.0008656992577016354,
0.007710420526564121,
-0.0081761684268713,
-0.008116228505969048,
-0.008536871522665024,
-0.006345021538436413,
-0.001062455354258418,
0.0010983007960021496,
-0.008865190669894218,
-0.012144222855567932,
0.01817479357123375,
-0.0031929013784974813,
-0.009218641556799412,
0.0011621993035078049,
-0.013913084752857685,
-0.00008754362352192402,
-0.01678307168185711,
0.01388182770460844,
0.007085415069013834,
0.00017522554844617844,
-0.004871712997555733
] | [
-0.08226258307695389,
-0.042634230107069016,
-0.2256844937801361,
-0.04321274161338806,
-0.2849970757961273,
0.09172575920820236,
0.14558014273643494,
-0.011421937495470047,
-0.33569666743278503,
-0.48326483368873596,
-0.010716746561229229,
-0.29275912046432495,
-0.7351230382919312,
0.4191530644893646,
0.397691547870636,
0.5713054537773132,
0.18860498070716858,
0.4118611514568329,
-0.08079203963279724,
-0.43331143260002136,
-0.2271202653646469,
-0.7177847027778625,
0.011150781996548176,
0.1977221965789795,
0.19576355814933777,
0.017753878608345985,
0.32643088698387146,
-0.26739493012428284,
0.7133703231811523,
-0.1079811081290245,
-0.16879335045814514,
0.8388135433197021,
-0.15892484784126282,
0.09042802453041077,
-0.19520148634910583,
-0.1654891073703766,
-0.5081883668899536,
0.24377097189426422,
0.019088879227638245,
-0.11512761563062668,
-0.0490417554974556,
-0.3773285448551178,
-0.5769131779670715,
0.31245917081832886,
-0.34937745332717896,
-0.42914721369743347,
-1.2136926651000977,
0.46186187863349915,
-0.21896423399448395,
-0.014907988719642162,
0.21734307706356049,
-0.05991457402706146,
-0.11878737062215805,
0.20457226037979126,
0.0058472128584980965,
0.20165342092514038,
-0.42941075563430786,
-0.08607016503810883,
0.2859269082546234,
-0.29608088731765747,
0.03942178562283516,
-0.2915186285972595,
-0.10414233803749084,
0.3008851110935211,
-0.13893043994903564,
1.115783929824829,
0.13110540807247162,
0.45787763595581055,
-0.5152506232261658,
-0.3046749532222748,
-0.13388122618198395,
-0.502525269985199,
-0.26056358218193054,
0.35448428988456726,
0.07732346653938293,
-0.03656059876084328,
-0.2212054282426834,
-0.363388329744339,
0.10285394638776779,
0.6403580904006958,
0.0009572899434715509,
0.34391579031944275,
0.26316842436790466,
-0.2291693091392517,
0.2550768256187439,
0.2550417184829712,
-0.21652524173259735,
0.6518495678901672,
-0.3508123457431793,
-0.15831074118614197,
0.2957618534564972,
0.12394815683364868,
0.6017922759056091,
-0.12915858626365662,
0.230966255068779,
0.40586069226264954,
-0.2551027834415436,
0.07045149803161621,
0.16706077754497528,
-0.007596260402351618,
-0.5837140679359436,
-0.2371198534965515,
-0.3119850754737854,
-0.4854835867881775,
-0.674824059009552,
-0.3238295018672943,
0.03484479337930679,
-1.0219091176986694,
-0.47760725021362305,
-0.2611343264579773,
-0.4923328757286072,
-0.03754989057779312,
-0.2741127014160156,
-0.3089198172092438,
-0.3499748408794403,
0.15231280028820038,
0.5196381211280823,
-0.5114777684211731,
0.14627064764499664,
0.10384605079889297,
-0.23578767478466034,
1.0997872352600098,
-0.26379525661468506,
0.4601970911026001,
0.19740569591522217,
-0.027313310652971268,
0.14595019817352295,
0.027519013732671738,
-0.2905001938343048,
0.45975831151008606,
0.13585972785949707,
0.6957753896713257,
-0.3131568133831024,
0.13313132524490356,
0.35879814624786377,
-0.14404095709323883,
-0.49830594658851624,
0.23867501318454742,
0.5444381237030029,
-0.33924600481987,
-0.6953387260437012,
-0.32907360792160034,
-0.2729942500591278,
0.016872523352503777,
-0.1133139580488205,
0.03877421095967293,
-0.5510601997375488,
-0.014705890789628029,
0.2795473635196686,
-0.39545559883117676,
0.10373378545045853,
-0.923988401889801,
-0.24682271480560303,
0.18410131335258484,
-0.22667793929576874,
0.003140713321045041,
0.017494646832346916,
0.3808693289756775,
0.18766073882579803,
0.39036285877227783,
0.6719576716423035,
0.0014128732727840543,
-0.4097231328487396,
-0.0041823661886155605,
0.4021743834018707,
0.08666840195655823,
0.3590537905693054,
0.2144048660993576,
-0.333421915769577,
-0.2269039750099182,
-0.39207878708839417,
-0.45280301570892334,
0.2906706929206848,
-0.3215276896953583,
-0.3057069778442383,
-0.13545294106006622,
0.33642610907554626,
-0.37558093667030334,
0.3689657151699066,
0.06581689417362213,
-0.627357006072998,
-0.06961015611886978,
0.18471753597259521,
-0.6713001132011414,
0.3947918713092804,
0.35401707887649536,
0.2229565680027008,
-0.09024514257907867,
0.3571004867553711,
0.703310489654541,
-0.29913604259490967,
-0.0025058449245989323,
0.266941100358963,
-0.2852734625339508,
1.0585347414016724,
-0.12565825879573822,
-0.31096577644348145,
1.46934974193573,
0.36536017060279846,
0.07084546983242035,
-0.07718414813280106,
-0.29676884412765503,
0.6723014116287231,
-0.3183879852294922,
-0.6886109113693237,
0.22525587677955627,
-0.2218542993068695,
-0.08044755458831787,
-0.2182205617427826,
0.02438274398446083,
0.6363189220428467,
0.007819254882633686,
0.1890624612569809,
-0.46906158328056335,
0.29424527287483215,
-0.024498226121068,
0.1670742630958557,
-0.24515300989151,
-0.4975695312023163,
-0.05056928098201752,
0.1383676379919052,
-0.8979231715202332,
0.5239921808242798,
0.761286199092865,
-0.28369948267936707,
0.7719360589981079,
0.22333961725234985,
-0.18454839289188385,
0.7398973703384399,
-0.30248382687568665,
0.4726950228214264,
-0.38817843794822693,
0.5191481709480286,
-0.10269772261381149,
0.33456024527549744,
0.1637493222951889,
0.04351396486163139,
-0.25641945004463196,
-0.09744296222925186,
0.08845571428537369,
0.14924760162830353,
0.6907209753990173,
-0.6010600924491882,
0.06240292638540268,
-0.02945685014128685,
-0.36759769916534424,
0.019058091565966606,
0.052374813705682755,
-0.422826886177063,
0.09451988339424133,
-0.013720924966037273,
0.0430382639169693,
0.5657995343208313,
-0.16018058359622955,
0.16770526766777039,
-0.0716601237654686,
0.27363184094429016,
-0.1352490931749344,
0.2782725989818573,
-0.3266659379005432,
-0.5844749212265015,
-0.07095348834991455,
0.11985268443822861,
0.35081544518470764,
-0.10623584687709808,
-0.5526247024536133,
-0.5303537845611572,
-0.041652463376522064,
0.6839452385902405,
0.754224419593811,
0.8959718942642212,
0.047658707946538925,
-0.4388701021671295,
-0.43052658438682556,
0.10621897131204605,
-0.8757230639457703,
0.2762618064880371,
1.0306203365325928,
-0.6972121596336365,
-0.5111016631126404,
-0.13209186494350433,
-0.12121165543794632,
0.7303624749183655,
-0.46511197090148926,
-0.19804924726486206,
-0.0967123806476593,
-0.10620573908090591,
-0.405898779630661,
-0.860255241394043,
-0.06637696921825409,
-0.15920455753803253,
0.47484079003334045,
-0.33618730306625366,
0.0026790143456310034,
0.19506053626537323,
0.046222228556871414,
-0.027623483911156654,
0.6711738705635071,
0.7628898620605469,
0.1559455394744873,
-0.36987730860710144,
0.1539340764284134,
-0.4688371419906616,
-0.0529823824763298,
0.03140982985496521,
0.3097986578941345,
0.13643497228622437,
-0.010899188928306103,
-5.983485698699951,
0.004840317647904158,
0.24266482889652252,
-0.27139121294021606,
-0.3321933448314667,
0.246596097946167,
1.060795545578003,
-0.017994889989495277,
0.29118770360946655,
0.04290883615612984,
0.2819088399410248,
0.15408824384212494,
0.09727109223604202,
-0.3589794933795929,
-0.08406464755535126,
-0.004177743103355169,
0.3999651372432709,
0.15407375991344452,
0.4972417950630188,
0.10539072751998901,
0.12814098596572876,
-0.0031120700296014547,
0.12797841429710388,
0.08376059681177139,
0.28254562616348267,
-0.3273583650588989,
-1.1635771989822388,
0.2602722942829132,
-0.09709510207176208,
-0.3036959767341614,
0.4138612151145935,
-0.40994992852211,
0.2079806923866272,
-0.4474516808986664,
-0.09014634042978287,
-0.3931807577610016,
0.14995314180850983,
-0.28643783926963806,
-0.1838715374469757,
-0.0796525850892067,
0.2760031521320343,
0.02149677462875843,
0.3571930229663849,
-0.25470924377441406,
-0.27719059586524963,
-0.04850596934556961,
0.11959049850702286,
0.08238696306943893,
-0.22663168609142303,
0.5295524001121521,
-0.0003052778774872422,
0.09466507285833359,
-0.021151073276996613,
0.5976709127426147,
0.4915386140346527,
0.35014718770980835,
-0.24124225974082947,
0.20340751111507416,
-0.7781531810760498,
0.09969864785671234,
0.02220822498202324,
-0.12910397350788116,
-0.20588168501853943,
-0.5033596158027649,
-0.005024062003940344,
-0.027966681867837906,
-0.5007952451705933,
-0.4253709316253662,
0.6837137937545776,
0.03107215091586113,
-0.4630829989910126,
0.19782595336437225,
0.241281658411026,
-0.675391435623169,
0.5202333927154541,
-0.6534823179244995,
-0.22365079820156097,
0.051694680005311966,
-0.41848888993263245,
-0.3820253610610962,
-0.6385639309883118,
-0.2882263660430908,
-0.026990626007318497,
0.005345400422811508,
0.5668377876281738,
0.02815917879343033,
-0.1627211570739746,
-0.016886083409190178,
-0.17730745673179626,
0.3512619435787201,
0.2650575339794159,
0.12712746858596802,
0.288451611995697,
0.5308708548545837,
-0.07457612454891205,
0.15572211146354675,
0.2039669156074524,
0.550787627696991,
0.7589623332023621,
0.2656133472919464,
1.0570141077041626,
-0.1735900640487671,
-0.47393494844436646,
-0.8114283084869385,
-0.2056700587272644,
0.2740393280982971,
-0.04456683620810509,
-0.02851606160402298,
0.874324381351471,
-0.6456265449523926,
0.024973709136247635,
0.03116793744266033,
0.1960265040397644,
0.03153720125555992,
0.4288724660873413,
-0.35037487745285034,
0.15083546936511993,
0.1823243796825409,
0.6683961749076843,
-0.5225972533226013,
0.2525361478328705,
0.6374261379241943,
-0.7970362305641174,
0.1114586591720581,
0.06798060983419418,
-0.0636272132396698,
0.20395253598690033,
0.05245447903871536,
-0.607661783695221,
-0.2457311451435089,
0.13117416203022003,
0.09308558702468872,
-0.24615803360939026,
-0.42873042821884155,
0.6551070809364319,
-0.12097867578268051,
-0.39647144079208374,
0.012807411141693592,
0.5056639313697815,
0.09294989705085754,
-0.11335084587335587,
-0.14477388560771942,
0.10535336285829544,
0.28291580080986023,
0.19619150459766388,
0.13845102488994598,
0.18077395856380463,
-0.1988995373249054,
-0.3571122884750366,
-0.4203071594238281,
0.2457810342311859,
-0.39105919003486633,
0.3794049620628357,
-0.041609425097703934,
-0.39333391189575195,
0.37148013710975647,
0.8797791600227356,
0.15170982480049133,
0.11031384766101837,
-0.5194835662841797,
0.499874472618103,
-0.26934826374053955,
-0.5497449040412903,
-0.0763651505112648,
0.05316302552819252,
-0.2274879515171051,
0.20383696258068085,
-0.43172213435173035,
-0.29832935333251953,
0.17844612896442413,
-0.20791497826576233,
-0.12643471360206604,
0.15117722749710083,
0.056408464908599854,
-0.25486093759536743,
0.2273319512605667,
-0.16495074331760406,
0.11531353741884232,
-0.3317733705043793,
0.3954346776008606,
-0.10604533553123474,
-0.30778107047080994,
-0.25340333580970764,
0.5241473317146301,
0.11109738796949387,
0.19553638994693756,
-0.2001134753227234,
0.0958218052983284,
-0.489035964012146,
-0.42632949352264404,
-0.1679868847131729,
0.037459347397089005,
0.17496243119239807,
-0.2535298466682434,
0.0626535713672638,
-0.10172083228826523,
-0.3426632881164551,
0.0027308149728924036,
0.061592694371938705,
-0.418376624584198,
0.1596219837665558,
0.502759575843811,
-0.21154095232486725,
0.30494967103004456,
-0.011916062794625759,
-0.03305647522211075,
-0.5375989079475403,
-0.2709762752056122,
0.53055340051651,
-0.06497771292924881,
0.11068145185709,
-0.683554470539093,
0.2730988562107086,
0.40048930048942566,
0.05845177173614502,
0.28379032015800476,
-0.1723041534423828,
-0.38502925634384155,
0.13276852667331696,
0.05869545042514801,
0.014720002189278603,
0.10152699798345566,
0.10343468934297562,
-0.14149868488311768,
-0.26513105630874634,
0.9389322996139526,
0.2335958480834961,
-1.139665961265564,
0.4341057538986206,
0.13382917642593384,
0.20567438006401062,
-0.459134578704834,
0.195027157664299,
0.3806568682193756,
-0.5808350443840027,
-0.8127346038818359,
0.013412353582680225,
-0.07096224278211594,
0.27501314878463745,
0.7077661156654358,
0.07064225524663925,
0.19877901673316956,
-0.41868919134140015,
-0.343750923871994,
-0.3393801152706146,
0.20309224724769592,
0.672576367855072,
-0.4027821719646454,
-0.5840862989425659,
0.26909109950065613,
-0.18749850988388062,
-0.4033450782299042,
-0.15887440741062164,
0.18143491446971893,
0.7985665202140808,
0.17241039872169495,
-0.3001234531402588,
0.046860113739967346,
-0.4365934729576111,
-0.30236300826072693,
0.003648538375273347,
0.1067836731672287,
-0.4498431384563446,
0.27105313539505005,
-0.25371310114860535,
-0.11585129797458649,
-0.3838697671890259,
-0.32699090242385864,
-0.04255228117108345,
-0.08076018840074539,
-0.565643310546875,
0.05941418930888176,
0.7928500771522522,
0.6246026158332825,
0.2105109989643097,
0.27520260214805603,
-0.013199621811509132,
0.5548099875450134,
-0.026553720235824585,
0.2412090301513672,
-0.22856488823890686,
-0.2547319829463959,
0.6057778596878052,
-0.5363370776176453,
0.20855233073234558,
-0.44961750507354736,
-0.21477872133255005,
-0.18292586505413055,
-0.032803136855363846,
-0.2912910580635071,
-0.40023037791252136,
0.18454861640930176,
-0.7477676272392273,
-0.693024754524231,
0.046541303396224976,
0.11266057938337326,
0.005973815452307463,
-0.0007216196390800178,
0.08311813324689865,
-0.255994975566864,
-0.9950442314147949,
0.562670886516571,
0.47585463523864746,
-0.360789954662323,
-0.18994145095348358,
0.09079441428184509,
0.3401193916797638,
0.2148653119802475,
-0.30669355392456055,
-0.0076973894611001015,
-0.07284204661846161,
-0.06160573288798332,
0.5279574990272522,
-0.15705810487270355,
-0.25208595395088196,
0.31734707951545715,
0.00584446219727397,
-0.18157066404819489,
0.1801668107509613,
-0.09881153702735901,
0.4033777415752411,
0.616685152053833,
0.3233591914176941,
-0.06677460670471191,
-0.7557778358459473,
0.3431471288204193,
-0.2648632228374481,
0.11200756579637527,
-0.09339401125907898,
0.6723578572273254,
0.3568125069141388,
-0.02857675775885582,
-0.046650271862745285,
0.5801777839660645,
0.3523024916648865,
0.15186557173728943,
-0.007447838317602873,
-0.393126517534256,
-0.05631604418158531,
0.21216362714767456,
1.2237650156021118,
0.5825913548469543,
-0.13587065041065216,
-0.03148879483342171,
0.06017176806926727,
0.16278357803821564,
0.1931685507297516,
0.06741373240947723,
0.21748031675815582,
0.24230019748210907,
0.10528288781642914,
-0.1206476166844368,
-0.4489959478378296,
0.22548754513263702,
-0.6312748789787292,
0.26353874802589417,
0.2455761581659317,
-0.38755983114242554,
-0.3328268229961395,
0.3702673017978668,
-0.4486297070980072,
0.2586321532726288,
0.009046926163136959,
0.8469836711883545,
-0.18267281353473663,
0.0030278274789452553,
0.37223753333091736,
0.2446908801794052,
-0.03150877356529236,
-0.29942771792411804,
0.39208897948265076,
-0.3764863610267639,
-0.005927552469074726,
0.5291005373001099,
0.16826336085796356,
-0.2621999680995941,
-0.15521438419818878,
0.09776462614536285,
-0.10382658243179321,
0.24363026022911072,
-0.3147316873073578,
-0.10578200221061707,
-0.04281223192811012,
-0.5969518423080444,
-0.0005892131594009697,
-0.4937554597854614,
-0.474429726600647,
-0.25248783826828003,
0.09227477759122849,
0.3051697611808777,
0.3212549090385437,
-0.33182600140571594,
0.021134085953235626,
0.2141440063714981,
0.3547098636627197,
0.074787437915802,
0.4157581329345703,
0.5012550354003906,
-0.10537107288837433,
0.5937418937683105,
-0.17571932077407837,
0.2786065936088562,
-0.22539302706718445,
0.21391265094280243,
-0.5797432661056519,
0.2940472662448883,
-0.15059000253677368,
0.13259224593639374,
-0.26202884316444397,
-0.0595303513109684,
0.9512391090393066,
0.6777657270431519,
-0.395864337682724,
0.5466411113739014,
0.042706023901700974,
-0.12148559093475342,
0.2930009067058563,
-0.6389238238334656,
-0.4179461598396301,
-0.6289563775062561,
-0.16627445816993713,
-0.7348144054412842,
0.4028415083885193,
-0.015114890411496162,
-0.46256041526794434,
-0.007009576074779034,
0.6397352814674377,
0.23786959052085876,
-0.1499096304178238,
0.657808780670166,
-0.35675695538520813,
0.17155320942401886,
-0.6089494824409485,
0.031258441507816315,
-0.7024475932121277,
0.06599146872758865,
-0.2749892771244049,
0.5011197924613953,
0.07111065834760666,
0.22804392874240875,
-0.16355416178703308,
-0.29597270488739014,
-0.14915835857391357,
0.12561459839344025,
0.29489365220069885,
0.35081884264945984,
-0.11514419317245483,
-0.4311716556549072,
-0.7298377752304077,
0.12266751378774643,
-0.003837611060589552,
0.031425513327121735,
-0.049015238881111145,
0.16651248931884766,
-0.37536779046058655,
-0.1082700863480568,
0.2986782193183899,
0.11546346545219421,
0.2534697353839874,
0.36789438128471375
] |
Beginning in 2003, highly pathogenic avian influenza (HPAI) H5N1 virus spread across Southeast Asia, causing unprecedented epidemics. Thailand was massively infected in 2004 and 2005 and continues today to experience sporadic outbreaks. While research findings suggest that the spread of HPAI H5N1 is influenced primarily by trade patterns, identifying the anthropogenic risk factors involved remains a challenge. In this study, we investigated which anthropogenic factors played a role in the risk of HPAI in Thailand using outbreak data from the “second wave” of the epidemic (3 July 2004 to 5 May 2005) in the country. We first performed a spatial analysis of the relative risk of HPAI H5N1 at the subdistrict level based on a hierarchical Bayesian model. We observed a strong spatial heterogeneity of the relative risk. We then tested a set of potential risk factors in a multivariable linear model. The results confirmed the role of free-grazing ducks and rice-cropping intensity but showed a weak association with fighting cock density. The results also revealed a set of anthropogenic factors significantly linked with the risk of HPAI. High risk was associated strongly with densely populated areas, short distances to a highway junction, and short distances to large cities. These findings highlight a new explanatory pattern for the risk of HPAI and indicate that, in addition to agro-environmental factors, anthropogenic factors play an important role in the spread of H5N1. To limit the spread of future outbreaks, efforts to control the movement of poultry products must be sustained. | [
-0.024918396025896072,
0.02565465122461319,
-0.0014864810509607196,
0.03203535079956055,
0.026659371331334114,
-0.002613302320241928,
0.010969802737236023,
0.02655409276485443,
-0.02048734575510025,
-0.01160064060240984,
-0.01282025221735239,
0.02228638157248497,
-0.02077593468129635,
0.01619623601436615,
0.00568211916834116,
0.011337639763951302,
0.0022145486436784267,
0.02987571805715561,
0.015701990574598312,
-0.027943164110183716,
-0.004656657576560974,
-0.003171205520629883,
0.01172078587114811,
-0.012245697900652885,
0.001530659617856145,
-0.011141929775476456,
-0.014600539579987526,
-0.011873912997543812,
-0.013487101532518864,
-0.002305363304913044,
0.04416687786579132,
0.021815937012434006,
0.008562268689274788,
0.010317124426364899,
0.005211998708546162,
0.025037823244929314,
-0.004062449559569359,
0.013410182669758797,
-0.006583591923117638,
-0.005555257201194763,
0.045639488846063614,
-0.016108334064483643,
0.00038767443038523197,
-0.010894356295466423,
-0.00839092768728733,
0.03950299695134163,
-0.014813963323831558,
0.006792091764509678,
-0.013052431866526604,
0.009514955803751945,
0.0017689689993858337,
-0.0014218343421816826,
-0.009443886578083038,
-0.014902251772582531,
-0.00708030303940177,
0.01829848811030388,
0.0206611305475235,
-0.005535930395126343,
-0.012482155114412308,
0.022188708186149597,
-0.01931137777864933,
0.003310837782919407,
0.00781580712646246,
-0.004373832140117884,
-0.015411796979606152,
-0.06670519709587097,
0.02058584615588188,
0.006271589547395706,
-0.010977141559123993,
-0.002679667668417096,
0.008725998923182487,
0.001506842439994216,
-0.008744405582547188,
-0.0020036695059388876,
-0.01651180349290371,
-0.009109513834118843,
0.0033058617264032364,
0.017292000353336334,
0.011435111053287983,
0.012983995489776134,
0.007210684008896351,
-0.003125368617475033,
0.02800450660288334,
0.01678893156349659,
-0.01806514710187912,
0.02948886528611183,
-0.013301340863108635,
0.00023109512403607368,
-0.003054669825360179,
-0.01205623522400856,
0.021264633163809776,
-0.00981697253882885,
-0.034041211009025574,
-0.024235446006059647,
-0.007529553957283497,
0.005805435124784708,
-0.012517813593149185,
-0.015750329941511154,
0.004919067956507206,
-0.011172214522957802,
-0.006624304223805666,
0.00869312696158886,
0.02182295173406601,
-0.008335663005709648,
0.013817789033055305,
0.00948204193264246,
-0.03766943886876106,
-0.007633660454303026,
0.01268315501511097,
-0.0013688920298591256,
-0.010910778306424618,
0.02597220242023468,
0.04709433764219284,
0.01591891422867775,
0.0015580924227833748,
-0.02377396821975708,
0.013478729873895645,
0.013088731095194817,
0.004226029850542545,
0.012779383920133114,
0.03682318329811096,
-0.027335483580827713,
-0.0056396895088255405,
0.003283548867329955,
-0.0024978334549814463,
-0.025004509836435318,
-0.01740436628460884,
-0.0004341462627053261,
-0.005002196412533522,
-0.01621035858988762,
-0.0073129283264279366,
0.01291801780462265,
-0.04312904179096222,
-0.00844336487352848,
0.004775917157530785,
0.00013259134721010923,
-0.018886597827076912,
0.006580485962331295,
-0.034988511353731155,
-0.015462392941117287,
-0.003248840570449829,
0.009476324543356895,
-0.00037745526060462,
0.014345617033541203,
0.03286713361740112,
0.008440929464995861,
-0.023254532366991043,
0.02042778953909874,
0.03665455803275108,
0.004686062224209309,
0.02115173637866974,
0.011966990306973457,
0.002548479475080967,
-0.02123536542057991,
-0.02705768495798111,
0.01788266934454441,
-0.0021030744537711143,
-0.016144923865795135,
-0.015092277899384499,
-0.002307487651705742,
-0.013516601175069809,
-0.032854169607162476,
0.0033771877642720938,
0.009162472561001778,
0.018836243078112602,
-0.013719553127884865,
0.02212541550397873,
-0.011143949814140797,
-0.0004628507886081934,
0.0034676846116781235,
-0.0024345717392861843,
0.01516691967844963,
-0.007470805663615465,
0.020871039479970932,
-0.014172335155308247,
-0.020256750285625458,
0.010919402353465557,
0.006706930696964264,
-0.007573205977678299,
0.06671052426099777,
-0.009420380927622318,
-0.0062669371254742146,
0.019262757152318954,
0.011108270846307278,
0.001977598061785102,
0.006514683365821838,
0.03841433674097061,
-0.010800860822200775,
0.027213096618652344,
0.004785253666341305,
-0.009571757167577744,
0.02405352145433426,
0.01026761531829834,
-0.00982147827744484,
-0.001795322634279728,
0.0028297188691794872,
0.03198646754026413,
0.003653431311249733,
-0.023369288071990013,
0.01972872018814087,
-0.004431716166436672,
0.015783589333295822,
0.035796571522951126,
-0.007409481331706047,
-0.012849202379584312,
0.01582394912838936,
0.02600964903831482,
0.011338528245687485,
-0.02200927585363388,
-0.022409312427043915,
0.004530923441052437,
0.0005704298382624984,
0.002680510515347123,
-0.002989233238622546,
-0.015549011528491974,
0.014683056622743607,
0.007611999288201332,
0.029979445040225983,
-0.007158796302974224,
-0.01821761578321457,
0.0004850140539929271,
0.01184639148414135,
-0.03789553418755531,
0.01728237047791481,
0.03358971327543259,
0.011844953522086143,
0.003369192825630307,
0.01297746878117323,
0.004988539963960648,
-0.0023987418971955776,
-0.016534993425011635,
-0.01353691890835762,
-0.013453103601932526,
-0.003407388459891081,
-0.0011073695495724678,
0.027801891788840294,
0.018135029822587967,
-0.013776561245322227,
0.01690567284822464,
-0.017819443717598915,
0.023992974311113358,
-0.0042920224368572235,
0.026844508945941925,
-0.015990659594535828,
0.022396383807063103,
0.00023505417630076408,
-0.0004059479106217623,
0.004822523333132267,
-0.01582268998026848,
-0.021876806393265724,
0.011484256014227867,
-0.027776839211583138,
-0.002746648620814085,
0.01095518283545971,
0.04023294150829315,
0.006790341343730688,
-0.008176019415259361,
-0.02477710135281086,
0.025018811225891113,
-0.020493965595960617,
0.016368500888347626,
0.003734593279659748,
0.011752201244235039,
-0.0072152018547058105,
-0.0006764812860637903,
0.0270327590405941,
0.0019400347955524921,
0.007228008005768061,
-0.012622471898794174,
0.010586205869913101,
0.008728348650038242,
-0.015222344547510147,
-0.009586438536643982,
-0.08096916973590851,
-0.010312790982425213,
0.0040093595162034035,
-0.042852818965911865,
0.011784861795604229,
0.01348967757076025,
0.021363385021686554,
-0.0003633228479884565,
-0.002486577956005931,
0.004927549045532942,
0.008554451167583466,
0.04472546651959419,
-0.002976291812956333,
-0.014066937379539013,
-0.0030545282643288374,
0.004195386543869972,
0.010539762675762177,
-0.0022289790213108063,
-0.0003962661139667034,
-0.00529210502281785,
0.009080932475626469,
-0.009335092268884182,
0.029606163501739502,
-0.010111733339726925,
-0.039047904312610626,
0.02341119572520256,
0.005030135624110699,
0.00017845584079623222,
-0.0022514360025525093,
-0.002664341824129224,
-0.005721833556890488,
-0.010644705966114998,
0.013843461871147156,
-0.03746959567070007,
0.02872854471206665,
-0.017330694943666458,
-0.00394035317003727,
-0.0081919115036726,
-0.025759633630514145,
0.007794556207954884,
-0.00805007852613926,
0.003575374372303486,
0.024909790605306625,
-0.003987293690443039,
-0.00080477399751544,
0.0010489539708942175,
-0.02427276410162449,
0.006118369288742542,
0.022760063409805298,
0.03087443672120571,
-0.013123968616127968,
-0.002056307625025511,
-0.008282707072794437,
0.0212022103369236,
-0.011479244567453861,
-0.028747983276844025,
0.006376360543072224,
-0.01319573912769556,
-0.00424584187567234,
-0.0044839587062597275,
-0.034838635474443436,
0.010037556290626526,
0.0022503207437694073,
-0.01734818145632744,
-0.024825461208820343,
-0.012691770680248737,
0.013578325510025024,
-0.0037389625795185566,
-0.01411927118897438,
0.010241098701953888,
-0.006698316894471645,
0.0036521730944514275,
0.01464295294135809,
-0.005419972352683544,
0.009681139141321182,
0.0014944567810744047,
-0.017133846879005432,
-0.008866354823112488,
-0.011162737384438515,
-0.002781347371637821,
-0.004609433934092522,
0.00946742296218872,
0.008693540468811989,
0.013321371749043465,
0.012725036591291428,
0.01339646615087986,
0.021990489214658737,
0.00465977331623435,
0.02038632705807686,
-0.022999756038188934,
-0.006730581633746624,
0.03655468299984932,
-0.019962873309850693,
0.013743230141699314,
-0.0075110276229679585,
-0.036955252289772034,
-0.011714903637766838,
0.008126579225063324,
-0.0029547810554504395,
0.009895971044898033,
-0.013803253881633282,
-0.016391027718782425,
0.0037323159631341696,
-0.011709261685609818,
-0.011201390996575356,
0.01840193383395672,
0.014197434298694134,
-0.02456602454185486,
-0.03451244905591011,
-0.0031142274383455515,
0.0006447150371968746,
0.005182582885026932,
-0.0005816477350890636,
0.0024597495794296265,
0.018677856773138046,
-0.00035092607140541077,
0.0015116326976567507,
-0.003964757546782494,
0.0711745172739029,
-0.0065168095752596855,
0.005793756805360317,
-0.023214980959892273,
0.018867362290620804,
-0.024335868656635284,
-0.006107578985393047,
-0.005293442402034998,
0.01076369546353817,
-0.017333174124360085,
0.013555963523685932,
-0.05071747303009033,
-0.015616027638316154,
-0.015730537474155426,
0.005332028027623892,
-0.020801588892936707,
0.015043959021568298,
0.005723186302930117,
0.016812577843666077,
0.01219707541167736,
0.0004085646942257881,
0.02732713334262371,
-0.0038474947214126587,
0.010454284027218819,
0.021228265017271042,
-0.0027925935573875904,
-0.015100634656846523,
-0.017857661470770836,
-0.019431307911872864,
0.01014675386250019,
0.009252114221453667,
-0.012125004082918167,
-0.009160172194242477,
-0.013477811589837074,
-0.007865611463785172,
-0.012236520648002625,
0.03367876261472702,
-0.009186435490846634,
-0.02035941369831562,
-0.01928061991930008,
-0.027437377721071243,
-0.012202314101159573,
0.0004197806119918823,
-0.0007539131329394877,
0.0026297923177480698,
0.024455145001411438,
-0.00583184789866209,
-0.010148944333195686,
-0.02039479836821556,
0.021326128393411636,
-0.00038940110243856907,
0.004538076929748058,
0.0052543212659657,
0.007102256640791893,
0.016224849969148636,
0.015331936068832874,
-0.017478860914707184,
0.004373410250991583,
0.019019752740859985,
-0.0056724268943071365,
-0.028046879917383194,
-0.04420042783021927,
0.004292719066143036,
-0.03162962943315506,
0.0007969038560986519,
-0.006927109323441982,
0.003572434652596712,
0.014995584264397621,
-0.036406561732292175,
-0.006584388669580221,
-0.006389282178133726,
-0.022341568022966385,
-0.0031224917620420456,
-0.018239326775074005,
-0.03340277448296547,
0.008675510063767433,
-0.0016606701537966728,
-0.008939913474023342,
0.012712555937469006,
-0.011595928110182285,
0.0068068727850914,
0.0027382918633520603,
-0.026128817349672318,
-0.016120128333568573,
-0.015404410660266876,
-0.0401616208255291,
-0.021054979413747787,
-0.07393352687358856,
-0.005913769826292992,
0.011011810973286629,
-0.005685421638190746,
0.016980651766061783,
0.006825757212936878,
-0.026218656450510025,
0.03459756821393967,
-0.024779800325632095,
-0.0071523841470479965,
0.015256581827998161,
0.0054818689823150635,
0.023566605523228645,
0.006976603996008635,
0.018595091998577118,
0.022325795143842697,
-0.0009396104142069817,
0.0032615880481898785,
-0.00787186250090599,
0.02975323051214218,
0.022578129544854164,
-0.005429623182862997,
-0.0555320680141449,
0.0035605563316494226,
0.006612004712224007,
-0.07995693385601044,
-0.02554270625114441,
0.01988285407423973,
-0.0163104385137558,
0.016725344583392143,
-0.01759682595729828,
-0.008344614878296852,
-0.011055883020162582,
-0.007728486321866512,
-0.017304059118032455,
-0.012692625634372234,
-0.03257553651928902,
0.025175459682941437,
-0.0029966586735099554,
0.03034752421081066,
-0.010512756183743477,
0.030937571078538895,
0.000283658504486084,
-0.018380075693130493,
0.00016917730681598186,
0.01024051383137703,
-0.006412260700017214,
-0.004471225664019585,
-0.0050194766372442245,
-0.011165527626872063,
-0.03198918700218201,
-0.01762494072318077,
0.01173719484359026,
-0.00625121733173728,
-0.025917328894138336,
-0.009537682868540287,
0.017328131943941116,
0.017139872536063194,
0.002635691314935684,
0.01666729897260666,
-0.017525898292660713,
0.031456541270017624,
-0.0208145584911108,
0.029646320268511772,
-0.006358107551932335,
-0.006906372494995594,
0.003067236626520753,
-0.004027107264846563,
0.0014856117777526379,
0.00020654965192079544,
-0.025123806670308113,
0.010313460603356361,
-0.018842849880456924,
0.027385838329792023,
-0.010139990597963333,
0.007576242089271545,
-0.025644497945904732,
-0.011276181787252426,
-0.0022590411826968193,
0.008526995778083801,
-0.00742898415774107,
-0.006537914276123047,
0.016326256096363068,
-0.015817174687981606,
0.02208741195499897,
0.008402353152632713,
0.0034801773726940155,
0.0008647949434816837,
0.0717083141207695,
-0.012217805720865726,
-0.0007229731418192387,
-0.019974172115325928,
-0.00964586902409792,
0.001137320650741458,
-0.016340436413884163,
0.0006287125870585442,
-0.03393518924713135,
-0.017588796094059944,
-0.01710721291601658,
-0.009061453863978386,
-0.011648309417068958,
0.016394134610891342,
0.015406439080834389,
-0.008009735494852066,
-0.002274026395753026,
0.008843393996357918,
-0.01236061379313469,
-0.00481945788487792,
-0.05115527659654617,
-0.006998205091804266,
-0.035858042538166046,
-0.02032068930566311,
0.03202688694000244,
0.005920130759477615,
-0.0355558805167675,
-0.009898299351334572,
-0.023127663880586624,
0.003385825315490365,
-0.021672235801815987,
0.006765203550457954,
0.0029209237545728683,
0.00020695384591817856,
0.021118853241205215,
-0.015876468271017075,
0.015562038868665695,
0.020778749138116837,
0.018160225823521614,
0.016422640532255173,
0.004583375528454781,
0.00038158451206982136,
0.01426202617585659,
-0.024671344086527824,
0.0075928266160190105,
-0.040297944098711014,
0.015417550690472126,
0.04220201447606087,
0.00784932728856802,
0.019893070682883263,
0.015455205924808979,
0.008522305637598038,
-0.002299610525369644,
-0.007711387705057859,
0.020821193233132362,
0.016364997252821922,
0.010335143655538559,
0.02243298850953579,
0.0014784717932343483,
0.02948780544102192,
0.011167103424668312,
0.006326415576040745,
0.005740559659898281,
-0.01716034486889839,
0.00141062680631876,
-0.025514930486679077,
0.02448829635977745,
-0.013186808675527573,
-0.02574065700173378,
0.007937466725707054,
-0.017013274133205414,
0.034881800413131714,
0.009960753843188286,
-0.004128302447497845,
0.02889486961066723,
0.034701645374298096,
0.04417114332318306,
0.004846904426813126,
0.0021207607351243496,
0.01001367624849081,
-0.018607527017593384,
-0.05116124078631401,
0.01597915031015873,
-0.003802383318543434,
-0.01098889671266079,
-0.0413186214864254,
-0.009240622632205486,
-0.0357712060213089,
-0.007439284585416317,
0.011858068406581879,
0.002911676187068224,
-0.000024292152374982834,
0.00023279327433556318,
0.0010335398837924004,
0.019417472183704376,
0.03475421667098999,
0.008018977008759975,
0.008063322864472866,
0.0007171342149376869,
-0.0049837371334433556,
-0.02548186108469963,
-0.026166554540395737,
0.0028839707374572754,
-0.007511149626225233,
-0.012466123327612877,
-0.005168084055185318,
0.0105969263240695,
-0.009907688945531845,
-0.008270931430161,
-0.010243711993098259,
0.022847723215818405,
0.030329886823892593,
0.012540297582745552,
-0.008412448689341545,
0.004646746441721916,
0.016285451129078865,
-0.02057911828160286,
-0.005535887088626623,
0.03335168957710266,
-0.01618758589029312,
-0.029147842898964882,
-0.005309755448251963,
-0.026696275919675827,
0.04264293611049652,
-0.011093313805758953,
-0.01226557046175003,
-0.00008935228106565773,
-0.01575281284749508,
-0.015973934903740883,
-0.0032784854993224144,
0.032907381653785706,
-0.0009339312091469765,
-0.007315829396247864,
-0.011520575731992722,
-0.008070584386587143,
0.001477172365412116,
-0.0024168179370462894,
0.005480712745338678,
0.007171912584453821,
0.013831059448421001,
0.010056708008050919,
-0.010281344875693321,
0.005655982531607151,
-0.023448355495929718,
0.010098611004650593,
-0.002208169549703598,
0.03804045543074608,
0.018354494124650955,
0.013235466554760933,
-0.0214402936398983,
0.01163085363805294,
0.017458952963352203,
0.014815437607467175,
-0.0070416610687971115,
-0.004218350164592266,
-0.0005696513690054417,
0.02399410493671894,
-0.04577856883406639,
-0.010099578648805618,
0.022666048258543015,
-0.013686850666999817,
-0.008797585032880306,
-0.015589484013617039,
0.0065261791460216045,
0.024315185844898224,
-0.0018380340188741684,
-0.026793241500854492,
0.016923610121011734,
0.008865916170179844,
0.006140246521681547,
-0.004392276052385569,
-0.006289682816714048,
0.010513080283999443,
-0.01253597903996706,
-0.0565478540956974,
-0.003909987397491932,
0.008605091832578182,
-0.004273205995559692,
-0.015986647456884384,
-0.0009582433849573135,
0.004475880414247513,
0.004696357995271683,
0.009646044112741947,
-0.013104871846735477,
-0.003137757070362568,
-0.028884675353765488,
-0.015594683587551117,
0.012732851319015026,
0.014889545738697052,
0.028286311775445938,
-0.04654630273580551,
-0.0036026015877723694,
-0.003366179298609495,
0.010788314044475555,
-0.005098122637718916,
0.0074216704815626144,
-0.03770019859075546,
-0.007485594600439072,
-0.0032870578579604626,
0.006315190345048904,
0.004468244966119528,
-0.005064619705080986
] | [
-0.1446288824081421,
-0.0016797836869955063,
-0.08815442025661469,
-0.33360186219215393,
-0.14443983137607574,
0.23351354897022247,
0.3542734980583191,
0.6417550444602966,
-0.9685312509536743,
-0.0016862102784216404,
0.07461204379796982,
-0.3895920515060425,
-0.6273003220558167,
0.3897813558578491,
-0.1769515722990036,
0.2488851398229599,
0.7106221914291382,
0.09877890348434448,
-0.03202725574374199,
-0.48889094591140747,
-0.4370884597301483,
-0.5036554932594299,
0.35934174060821533,
0.3969748318195343,
0.1364489048719406,
-0.31935983896255493,
0.2027670294046402,
0.44917333126068115,
0.8085429668426514,
-0.4860903322696686,
0.23816215991973877,
0.6771368384361267,
0.5619245767593384,
-0.18919603526592255,
-0.3452758491039276,
0.16061624884605408,
-0.16965530812740326,
0.24745722115039825,
-0.39919576048851013,
-0.30125555396080017,
-0.11866828799247742,
-0.22728629410266876,
-0.23383747041225433,
-0.07388336211442947,
0.10254807770252228,
-0.9339963793754578,
-1.0551531314849854,
0.4773099422454834,
-0.11808145046234131,
0.49814343452453613,
-0.34249815344810486,
0.2895025312900543,
-0.07598664611577988,
-0.5271344184875488,
0.19916802644729614,
0.612541913986206,
-0.3346012234687805,
0.23751148581504822,
-0.23111796379089355,
-0.3626196086406708,
0.4472704827785492,
-0.4590925872325897,
0.0493692047894001,
0.10442877560853958,
-0.791246235370636,
1.1086997985839844,
0.44561371207237244,
0.26928359270095825,
0.5522595047950745,
-0.6204065680503845,
0.1328582763671875,
-0.33607012033462524,
-0.24084486067295074,
0.33358320593833923,
-0.32593992352485657,
-0.3847084641456604,
-0.28758272528648376,
-0.524566650390625,
0.054102227091789246,
0.43369701504707336,
0.06128043308854103,
0.3492682874202728,
0.7386317253112793,
-0.40997350215911865,
0.5271092653274536,
-0.05828185752034187,
0.33678796887397766,
0.7304794192314148,
0.11109965294599533,
0.07302248477935791,
-0.09305749833583832,
0.1342853456735611,
0.680272102355957,
0.2872832119464874,
-0.5113268494606018,
0.027383772656321526,
-0.09347222745418549,
0.10724575072526932,
0.5763503909111023,
0.09417872130870819,
-0.3819884955883026,
-0.02628905326128006,
0.06606771051883698,
-0.16095465421676636,
-0.38110169768333435,
-0.28347957134246826,
-0.39822933077812195,
-0.5077912211418152,
-0.5712243914604187,
-0.34197986125946045,
-0.6960377097129822,
-0.18821321427822113,
-0.09645865112543106,
-0.017228735610842705,
-0.22622792422771454,
0.34481263160705566,
0.14512650668621063,
-0.9617249965667725,
0.25070464611053467,
-0.17774078249931335,
-0.022941183298826218,
0.5495606660842896,
-0.3461245000362396,
0.7700208425521851,
0.004247008822858334,
-0.043238285928964615,
0.3983381688594818,
-0.37044259905815125,
-0.15982595086097717,
0.8320319056510925,
0.06570591777563095,
0.7522112131118774,
-0.2219679057598114,
-0.09940845519304276,
0.36725619435310364,
0.5476241111755371,
0.03603862598538399,
0.5095053911209106,
-0.019114911556243896,
-0.5024217963218689,
-0.5522743463516235,
-0.428461492061615,
-0.6933003067970276,
0.351978063583374,
-0.34246012568473816,
0.21041277050971985,
-0.14478079974651337,
-0.40417763590812683,
-0.35449329018592834,
-0.5972124934196472,
-0.0660301074385643,
-0.4037129282951355,
-0.5473971366882324,
0.33494868874549866,
0.24688899517059326,
0.8362331390380859,
0.030976975336670876,
0.0006241033552214503,
0.6535893082618713,
0.14998996257781982,
0.4232929050922394,
0.11119713634252548,
-0.30720821022987366,
-0.2818605303764343,
-0.012454727664589882,
0.3013727068901062,
-0.07934620976448059,
0.4443698823451996,
-0.11878332495689392,
-0.12454652786254883,
-0.6792955994606018,
-0.21352173388004303,
-0.33885154128074646,
-0.04168429970741272,
-0.02955727092921734,
-0.3672008216381073,
0.09690337628126144,
-0.015361820347607136,
-0.05365954339504242,
0.6979465484619141,
-0.5835995674133301,
0.3653597831726074,
0.1161079853773117,
-0.17290112376213074,
0.45768222212791443,
0.37382015585899353,
0.3442978858947754,
0.22304867208003998,
0.26935505867004395,
0.21208614110946655,
-0.3078392744064331,
-0.2566055953502655,
0.3421977758407593,
-0.23532167077064514,
0.7873945832252502,
0.06788674741983414,
-0.13948111236095428,
1.6528942584991455,
0.3758273422718048,
0.683052122592926,
-0.162986159324646,
0.32645195722579956,
0.5223053693771362,
-0.3414120674133301,
-0.9468678832054138,
-0.21868470311164856,
-0.3128855526447296,
-0.029276730492711067,
-0.06272930651903152,
0.5189651250839233,
0.1403113454580307,
-0.24222855269908905,
-0.7122746706008911,
-0.2773309350013733,
0.6118572950363159,
0.48427003622055054,
-0.19624000787734985,
-0.5046824812889099,
-0.12882883846759796,
-0.24794863164424896,
0.028235644102096558,
-0.6445898413658142,
0.14998726546764374,
0.7655191421508789,
0.34891217947006226,
0.7578994035720825,
0.465494304895401,
-0.18264038860797882,
0.8079675436019897,
-0.605864405632019,
-0.02143356017768383,
-0.3219727873802185,
0.5741426348686218,
-0.5353631973266602,
0.007975714281201363,
0.24195033311843872,
0.11748287081718445,
-0.26736941933631897,
-0.11857499182224274,
0.026590624824166298,
0.6405104398727417,
0.2912488877773285,
-0.059432875365018845,
0.2746545672416687,
0.027885528281331062,
-0.14012661576271057,
-0.47539517283439636,
-0.7227584719657898,
-0.6490650773048401,
0.019481094554066658,
0.31841692328453064,
0.566634476184845,
0.24571013450622559,
-0.15833908319473267,
-0.10224244743585587,
0.013825735077261925,
0.09060381352901459,
-0.24901965260505676,
0.19091521203517914,
-0.5571618676185608,
0.20865274965763092,
-0.254209041595459,
0.3963189721107483,
0.4725554883480072,
-0.06995192915201187,
-0.2867656350135803,
-0.3644486963748932,
-0.599607527256012,
0.35737335681915283,
0.5071302652359009,
0.31816673278808594,
-0.16554783284664154,
-0.27473244071006775,
0.011292200535535812,
0.28743940591812134,
-0.808506429195404,
-0.27824974060058594,
0.9077796936035156,
-1.1161706447601318,
-0.39451536536216736,
-0.02640901319682598,
0.3225897252559662,
0.7557604312896729,
-0.6218416094779968,
-0.12486040592193604,
0.13258829712867737,
-0.5258328318595886,
-0.47191545367240906,
-0.6207656860351562,
0.24593989551067352,
0.329872190952301,
-0.4584313631057739,
-0.2501683533191681,
0.28708308935165405,
-0.02786107175052166,
-0.3868161737918854,
-0.09939940273761749,
0.48182427883148193,
0.8087377548217773,
0.05101906508207321,
-0.04213123396039009,
0.15704448521137238,
-0.5914644002914429,
0.010072801262140274,
-0.22274969518184662,
0.010257997550070286,
-0.294834703207016,
0.006413292605429888,
-5.898948669433594,
-0.16870152950286865,
0.20046202838420868,
-0.3432786464691162,
-0.39373040199279785,
0.42764878273010254,
0.5032496452331543,
-0.07608658820390701,
0.19415593147277832,
0.35819610953330994,
1.0779051780700684,
0.336935818195343,
0.16346979141235352,
-0.21517081558704376,
-0.4072715938091278,
0.0950225293636322,
-0.09238126128911972,
0.11692444980144501,
0.3800424039363861,
0.017003078013658524,
0.27521541714668274,
-0.4486303925514221,
-0.20153117179870605,
0.4021286964416504,
0.04236104339361191,
0.29294338822364807,
-0.47475919127464294,
0.08932684361934662,
-0.5752111077308655,
-0.029389414936304092,
-0.2673007845878601,
-0.3288200795650482,
0.04755261540412903,
0.12992936372756958,
-0.5420632362365723,
-0.030851442366838455,
0.17249572277069092,
-0.12981978058815002,
-0.16514043509960175,
-0.3836999535560608,
0.06826668977737427,
-0.6959695816040039,
-0.09130274504423141,
-0.3037935197353363,
0.16079506278038025,
-0.046008698642253876,
-0.03476554900407791,
0.36773571372032166,
-0.20367123186588287,
0.3820713460445404,
0.21733063459396362,
-0.08217404037714005,
0.13077186048030853,
0.7172950506210327,
0.12811386585235596,
0.1886761337518692,
-0.4251447916030884,
-0.3030836582183838,
-0.2552829384803772,
0.1171598806977272,
0.22415995597839355,
-0.0029321752954274416,
-0.08865697681903839,
-0.46894243359565735,
0.17987936735153198,
0.06047133356332779,
-0.029422327876091003,
-0.3417954742908478,
0.5381706953048706,
-0.18175193667411804,
-0.3711477518081665,
0.012539061717689037,
0.18723054230213165,
-0.762643039226532,
0.2205030620098114,
-1.036420226097107,
0.0712449923157692,
0.2365313023328781,
-0.12648813426494598,
-0.1315641850233078,
-0.12017370015382767,
0.008460333570837975,
0.05416077375411987,
-0.22541607916355133,
0.1754850596189499,
-0.43183058500289917,
-0.08017431199550629,
-0.17473472654819489,
-0.0008985368767753243,
0.36185041069984436,
0.7552574276924133,
-0.49756765365600586,
0.10248741507530212,
0.7531094551086426,
0.4243188798427582,
0.5134043097496033,
0.41702181100845337,
0.1398957222700119,
0.32649102807044983,
-0.19006775319576263,
0.46539509296417236,
-0.09162594377994537,
-0.43023020029067993,
-0.5027903914451599,
-0.12082114070653915,
-0.2559742033481598,
-0.15816204249858856,
-0.12621724605560303,
0.7397707104682922,
-0.3921044170856476,
0.11160367727279663,
-0.23244450986385345,
-0.053515758365392685,
-0.10612815618515015,
0.25829675793647766,
-0.1552485078573227,
0.35534992814064026,
0.2748126685619354,
0.055756837129592896,
-0.22416651248931885,
0.24239464104175568,
0.15299475193023682,
-0.183798149228096,
0.6584024429321289,
0.9128298163414001,
-0.001699400832876563,
-0.3145035207271576,
0.6714352965354919,
-0.2994619607925415,
-0.366443395614624,
0.39708948135375977,
0.1358315795660019,
0.5071514844894409,
-0.0970563143491745,
0.16015370190143585,
-0.4359576106071472,
-0.2742556631565094,
-0.38381120562553406,
0.3227400481700897,
0.07108276337385178,
-0.03426343575119972,
0.2708401381969452,
-0.19186913967132568,
0.10280769318342209,
-0.31309452652931213,
0.015601511113345623,
0.0545148104429245,
-0.25566428899765015,
-0.22179479897022247,
-0.08197581022977829,
-0.21425889432430267,
-0.4516897201538086,
0.4172760546207428,
0.39206230640411377,
-0.8258680105209351,
0.28462785482406616,
0.5945006608963013,
0.26011425256729126,
-0.05410091206431389,
-0.21415351331233978,
0.121646948158741,
-0.09246064722537994,
-0.7878676652908325,
0.03643771633505821,
-0.22802475094795227,
0.2552826404571533,
0.5472007989883423,
-0.2286795675754547,
-0.0872109904885292,
0.28559446334838867,
0.23351170122623444,
-0.2936303913593292,
-0.007666479796171188,
0.8036924004554749,
0.22435973584651947,
-0.19658327102661133,
-0.373328298330307,
-0.4413948357105255,
0.229231059551239,
0.5649908185005188,
-0.15314564108848572,
-0.2742106020450592,
-0.842881441116333,
0.47712406516075134,
0.49460920691490173,
0.34104397892951965,
0.01912429742515087,
-0.9600811004638672,
-0.04051496461033821,
0.08998765796422958,
0.5691552758216858,
0.20013923943042755,
-0.002617870457470417,
0.2623971998691559,
0.192498579621315,
-0.5424524545669556,
-0.24009715020656586,
0.21895593404769897,
-0.27715641260147095,
-0.3670395314693451,
0.0474567636847496,
0.5974106192588806,
-0.1955772489309311,
-0.19051608443260193,
0.25186634063720703,
-0.45140504837036133,
0.03287340700626373,
-0.028297184035182,
0.04283858463168144,
-0.4044652581214905,
0.10230165719985962,
-0.18558375537395477,
0.12677864730358124,
1.0054196119308472,
0.07454123347997665,
0.28501152992248535,
-0.2169908881187439,
-0.3043614625930786,
-0.050706807523965836,
-0.16601042449474335,
-0.49818024039268494,
-0.19550774991512299,
-0.6325898170471191,
-0.6471049785614014,
-0.9294232726097107,
0.6665648818016052,
0.2070850431919098,
-1.077195405960083,
0.10624320060014725,
-0.025080468505620956,
0.17741815745830536,
-0.14237242937088013,
0.3441784977912903,
0.4502105414867401,
-0.28441253304481506,
-0.15060469508171082,
0.5220493674278259,
-0.30179113149642944,
0.48721200227737427,
0.5592367053031921,
-0.17483937740325928,
0.7027339339256287,
-0.11857336759567261,
-0.47498080134391785,
-0.5482634902000427,
-0.11129982769489288,
0.12434332072734833,
-0.5283505320549011,
-0.23502857983112335,
0.3083173334598541,
-0.17392918467521667,
-0.2753262221813202,
0.490168958902359,
0.0254465714097023,
0.742579996585846,
-0.1491701453924179,
-0.23700837790966034,
-0.1315835863351822,
-0.29948189854621887,
-0.34248924255371094,
-0.34119394421577454,
-0.01781952567398548,
-0.22080910205841064,
-0.3602258265018463,
0.045221224427223206,
-0.14639653265476227,
-0.5146830081939697,
-0.2536999583244324,
0.04585354030132294,
-0.2942902445793152,
0.04931768774986267,
-0.5179435014724731,
0.2997719347476959,
0.13268861174583435,
0.44630956649780273,
0.14258728921413422,
-0.4655204117298126,
-0.17511582374572754,
-0.08798571676015854,
0.41048383712768555,
-0.06498337537050247,
-0.5642299056053162,
-0.10618734359741211,
-0.1295403391122818,
0.2634966969490051,
-0.7119880318641663,
0.14728568494319916,
-0.23120100796222687,
0.09829238057136536,
-0.3295626640319824,
-0.07806284725666046,
0.4658655524253845,
-0.5754801034927368,
-0.026441261172294617,
0.05049106106162071,
0.13455452024936676,
0.3587138056755066,
0.43375828862190247,
-0.43234944343566895,
-0.35920390486717224,
-0.6390270590782166,
0.3815314471721649,
0.2813585102558136,
-0.1713680773973465,
-0.16296520829200745,
0.010420302860438824,
0.247065007686615,
0.2082408219575882,
-0.293255478143692,
0.645492434501648,
0.6317364573478699,
-0.04871302470564842,
-0.07944415509700775,
-0.11456556618213654,
-0.546295702457428,
0.32878878712654114,
-0.07965155690908432,
-0.4816063642501831,
0.36695435643196106,
-0.26291579008102417,
0.30390846729278564,
0.6041089296340942,
0.022858597338199615,
0.12934571504592896,
-0.32237398624420166,
0.7169346213340759,
-0.14916250109672546,
0.25990813970565796,
0.31078556180000305,
0.40886548161506653,
0.18326647579669952,
-0.22153955698013306,
-0.46097061038017273,
-0.14645759761333466,
0.3306046426296234,
0.003833251539617777,
-0.02932913601398468,
-0.5660946369171143,
-0.19347739219665527,
-0.018410641700029373,
1.2354604005813599,
0.1100408211350441,
0.0031906890217214823,
-0.23312382400035858,
0.25731125473976135,
-0.11613088101148605,
0.3522544503211975,
-0.02069154381752014,
0.37443646788597107,
-0.2546083927154541,
0.25386443734169006,
0.13575740158557892,
0.1273057758808136,
0.2111901491880417,
-0.15232811868190765,
0.05654730647802353,
-0.5124282240867615,
-0.24563060700893402,
0.01240228209644556,
0.15208940207958221,
0.4341287314891815,
-0.12010508030653,
0.02612834982573986,
0.666206955909729,
0.4628821015357971,
-0.1622476726770401,
0.24717919528484344,
0.11179833859205246,
0.21546705067157745,
-0.11867792904376984,
-0.007268413435667753,
-0.14234384894371033,
-0.08048165589570999,
0.14593376219272614,
0.11476363986730576,
-0.22744522988796234,
-0.07532473653554916,
0.007060224190354347,
-0.191181018948555,
0.5029715895652771,
-0.20856253802776337,
0.012185215950012207,
0.1402759999036789,
-0.7058137059211731,
-0.02335643395781517,
0.1624567210674286,
-0.1893441379070282,
0.30490848422050476,
-0.1658385694026947,
-0.1722022444009781,
0.08881966769695282,
-0.38188791275024414,
-0.13646920025348663,
0.6057608723640442,
0.27700120210647583,
0.12710431218147278,
-0.08756670355796814,
0.5229268670082092,
0.07742353528738022,
0.2697213888168335,
0.12251336127519608,
-0.38657915592193604,
-0.12460984289646149,
0.4257805049419403,
-0.37793707847595215,
0.32064032554626465,
-0.5956363677978516,
-0.24300643801689148,
-0.6027486324310303,
0.2673378586769104,
0.3085097372531891,
1.0844157934188843,
-0.03294406831264496,
0.1754751056432724,
-0.46426835656166077,
-0.12238934636116028,
0.41848108172416687,
-0.8689390420913696,
-0.20388108491897583,
-0.6842396259307861,
-0.608587920665741,
-0.4799607992172241,
0.4684234857559204,
0.176770880818367,
0.15168772637844086,
-0.2916297912597656,
0.3646256625652313,
0.32161644101142883,
0.13623201847076416,
0.7792537212371826,
-0.11776306480169296,
0.3883028030395508,
-0.4719224274158478,
-0.1629296988248825,
-0.6877521276473999,
-0.05059254541993141,
0.2487882524728775,
0.112173892557621,
0.42271628975868225,
0.32029062509536743,
0.40187013149261475,
-0.4563271999359131,
0.14217135310173035,
-0.06660240143537521,
0.5177798867225647,
-0.12986791133880615,
-0.12207968533039093,
-0.3897446095943451,
-0.5864568948745728,
0.510187029838562,
0.14894333481788635,
-0.17322324216365814,
0.11517331749200821,
-0.15509815514087677,
0.14945702254772186,
0.519115149974823,
0.049639198929071426,
-0.061243731528520584,
0.0032614043448120356,
-0.34493038058280945
] |
BACKGROUND: The genetic contributions to human common disorders and mouse genetic models of disease are complex and often overlapping. In common human diseases, unlike classical Mendelian disorders, genetic factors generally have small effect sizes, are multifactorial, and are highly pleiotropic. Likewise, mouse genetic models of disease often have pleiotropic and overlapping phenotypes. Moreover, phenotypic descriptions in the literature in both human and mouse are often poorly characterized and difficult to compare directly. METHODS: In this report, human genetic association results from the literature are summarized with regard to replication, disease phenotype, and gene specific results; and organized in the context of a systematic disease ontology. Similarly summarized mouse genetic disease models are organized within the Mammalian Phenotype ontology. Human and mouse disease and phenotype based gene sets are identified. These disease gene sets are then compared individually and in large groups through dendrogram analysis and hierarchical clustering analysis. RESULTS: Human disease and mouse phenotype gene sets are shown to group into disease and phenotypically relevant groups at both a coarse and fine level based on gene sharing. CONCLUSION: This analysis provides a systematic and global perspective on the genetics of common human disease as compared to itself and in the context of mouse genetic models of disease. | [
-0.005607008934020996,
0.017874974757432938,
-0.012838255614042282,
0.02579958364367485,
0.02532232739031315,
-0.013680703938007355,
0.01250405516475439,
0.0031248582527041435,
-0.019780632108449936,
-0.015238933265209198,
-0.018502455204725266,
0.008097768761217594,
-0.0017821810906752944,
0.007498832885175943,
-0.0014418824575841427,
0.007109600119292736,
-0.019998785108327866,
0.008960379287600517,
0.009198997169733047,
0.006048982497304678,
0.029947519302368164,
0.01747577264904976,
0.011411020532250404,
0.036006998270750046,
0.02280593477189541,
-0.0031055614817887545,
0.019852738827466965,
-0.018353985622525215,
-0.028706632554531097,
0.00574002880603075,
0.010181539691984653,
0.003943387884646654,
0.007812133990228176,
0.03221158683300018,
0.001771439565345645,
0.02205410972237587,
0.008713463321328163,
0.02776040881872177,
0.01288715098053217,
-0.005521909333765507,
-0.006464165169745684,
0.000730718020349741,
0.002344807144254446,
-0.013356502167880535,
-0.010008874349296093,
-0.017634104937314987,
-0.0037265052087605,
-0.009505338966846466,
0.012196483090519905,
0.0074241021648049355,
-0.02018335834145546,
-0.007837344892323017,
-0.017105523496866226,
-0.004645531997084618,
-0.007633302826434374,
0.0031015644781291485,
0.022549837827682495,
-0.012573327869176865,
-0.0073728179559111595,
0.049818653613328934,
0.016020294278860092,
-0.0008578852284699678,
-0.009323147125542164,
0.0016006557270884514,
-0.013950245454907417,
-0.06673170626163483,
0.012970908544957638,
0.007588482927531004,
-0.00888306275010109,
0.00011030817404389381,
0.0061742146499454975,
0.00920434296131134,
0.03230658918619156,
-0.016913559287786484,
-0.0031754695810377598,
-0.005685322917997837,
-0.006510143168270588,
0.04129772633314133,
0.03659442067146301,
-0.008060580119490623,
0.023850368335843086,
-0.023129837587475777,
-0.008138129487633705,
0.020805446431040764,
-0.012540960684418678,
0.030275793746113777,
-0.03605198115110397,
-0.004903504624962807,
-0.0038824474904686213,
0.01945754885673523,
0.008488370105624199,
-0.03913247585296631,
-0.012519771233201027,
-0.021062150597572327,
-0.06450267881155014,
-0.006287326104938984,
-0.0368252769112587,
0.026821289211511612,
-0.007487001828849316,
-0.019574416801333427,
-0.019789069890975952,
0.0013660902623087168,
0.03137531876564026,
0.016849741339683533,
0.004675619769841433,
0.020605871453881264,
-0.0011119619011878967,
0.029952771961688995,
0.04999881982803345,
0.014839142560958862,
-0.01378810778260231,
0.02000102400779724,
-0.0009938832372426987,
0.011360421776771545,
0.023751862347126007,
0.01066382136195898,
-0.003049977356567979,
0.04740077629685402,
0.008628832176327705,
-0.020781371742486954,
0.0443703755736351,
-0.008649337105453014,
-0.02203051745891571,
0.042020250111818314,
0.004503998905420303,
-0.014129405841231346,
0.017699681222438812,
0.014683302491903305,
0.012196246534585953,
0.004379752092063427,
-0.009411152452230453,
0.008646491914987564,
-0.014082302339375019,
0.012828636914491653,
-0.0013777129352092743,
-0.021952757611870766,
-0.04942639544606209,
0.008119318634271622,
-0.0010809639934450388,
-0.03063073754310608,
-0.006740412674844265,
0.016231950372457504,
0.007427553180605173,
0.0029970169998705387,
0.014999961480498314,
0.0006095609278418124,
-0.012884768657386303,
0.018961681053042412,
0.030327778309583664,
-0.009419127367436886,
0.02125569060444832,
0.01295911893248558,
-0.022347301244735718,
-0.022801034152507782,
-0.029318829998373985,
-0.014348727650940418,
-0.012362215667963028,
0.014222292229533195,
0.012887815944850445,
0.022720370441675186,
-0.04018816351890564,
-0.031229624524712563,
0.032293207943439484,
0.010114714503288269,
0.0025197374634444714,
0.018928078934550285,
-0.00882827490568161,
-0.022085629403591156,
0.013359448872506618,
0.004195698536932468,
-0.014406854286789894,
-0.03866904228925705,
0.007405334152281284,
0.02235291339457035,
-0.018016628921031952,
0.005894734524190426,
0.013029095716774464,
0.009532341733574867,
-0.006662691943347454,
0.06687509268522263,
-0.014049768447875977,
0.006642724387347698,
-0.01453673467040062,
-0.00011550728231668472,
0.01068633422255516,
-0.028756000101566315,
0.010973414406180382,
-0.014735972508788109,
-0.016919195652008057,
-0.02377612516283989,
-0.009394378401339054,
0.02091195434331894,
0.01440103817731142,
0.027297575026750565,
-0.03143378719687462,
0.004070815164595842,
-0.014445168897509575,
-0.003375934436917305,
0.021231047809123993,
0.02082255855202675,
0.01062757708132267,
-0.005264280829578638,
0.022093215957283974,
-0.0134628526866436,
0.032765768468379974,
0.017737358808517456,
0.018956415355205536,
-0.008482907898724079,
0.010056419298052788,
0.0054324958473443985,
0.02105051651597023,
0.007838878780603409,
-0.014193420298397541,
-0.006156177259981632,
-0.02059522271156311,
-0.012105349451303482,
-0.03793160989880562,
-0.004062466323375702,
-0.003742440603673458,
-0.01765490137040615,
0.0022092959843575954,
-0.0064594680443406105,
0.00794058758765459,
-0.010642021894454956,
0.02028702199459076,
-0.01764131709933281,
0.006721261888742447,
0.013273268938064575,
0.0025136100593954325,
-0.005211275070905685,
-0.03310266137123108,
-0.017486201599240303,
-0.011995533481240273,
0.012168075889348984,
0.030604513362050056,
0.01834629848599434,
0.015716206282377243,
-0.0027366383001208305,
0.01875750534236431,
-0.01164542231708765,
-0.02195153385400772,
0.007209938019514084,
0.028667666018009186,
-0.03175695613026619,
0.025318363681435585,
0.00290429568849504,
0.015705954283475876,
0.03830090910196304,
-0.003969909623265266,
-0.029179193079471588,
0.0066534774377942085,
-0.01422406081110239,
0.012189489789307117,
-0.018629293888807297,
0.0019332231022417545,
0.03012610785663128,
0.012109302915632725,
0.0026014603208750486,
0.023518867790699005,
0.005441405810415745,
0.00847504660487175,
0.005788291804492474,
-0.004945958033204079,
0.005954071879386902,
-0.002283695852383971,
-0.000039247795939445496,
0.03462284058332443,
0.039817534387111664,
0.01977439597249031,
-0.028846539556980133,
0.009893491864204407,
-0.015889011323451996,
0.004816419444978237,
-0.08062797784805298,
-0.008351702243089676,
0.0049214838072657585,
0.006882562767714262,
0.013050863519310951,
-0.003279866185039282,
-0.002704042010009289,
-0.014093177393078804,
-0.0029910572338849306,
-0.028013266623020172,
0.025195550173521042,
-0.017098721116781235,
-0.010786649771034718,
0.02213539555668831,
0.0017956099472939968,
-0.01026700809597969,
0.01583980768918991,
0.007746793795377016,
-0.010770303197205067,
-0.057138681411743164,
0.015030285343527794,
-0.013375150971114635,
-0.0003748538438230753,
-0.004698839504271746,
0.01103493943810463,
0.03124849870800972,
0.02884661965072155,
0.0036973184905946255,
0.010869577527046204,
0.009171904064714909,
-0.0180074293166399,
-0.031676992774009705,
0.011764589697122574,
-0.012448133900761604,
0.0062503996305167675,
-0.03904709219932556,
-0.005742969922721386,
0.0001336431596428156,
-0.010858077555894852,
0.023931344971060753,
-0.019527703523635864,
0.02067970298230648,
0.016934329643845558,
-0.018835145980119705,
0.013287035748362541,
0.006505529396235943,
0.04064619541168213,
-0.02020745538175106,
0.016304263845086098,
0.015367107465863228,
0.0422375425696373,
0.001237874268554151,
0.0336797796189785,
0.008881686255335808,
-0.009280506521463394,
-0.0137881338596344,
-0.000042941421270370483,
-0.012476682662963867,
-0.013391337357461452,
-0.006279638968408108,
0.0023008855059742928,
0.023412317037582397,
0.010229875333607197,
-0.005939785856753588,
-0.008749502710998058,
-0.010079829022288322,
0.007942724972963333,
-0.00843256525695324,
-0.02045176737010479,
0.008351203054189682,
0.04670029133558273,
0.0034842772874981165,
0.01793559640645981,
-0.010121860541403294,
0.01389138400554657,
-0.013107976876199245,
-0.023395143449306488,
-0.017612159252166748,
0.03744634985923767,
0.0024001840502023697,
-0.0230550654232502,
0.00884267222136259,
-0.025808293372392654,
-0.0007635194342583418,
-0.025972958654165268,
-0.008550943806767464,
0.0010819464223459363,
-0.007396804168820381,
0.020636701956391335,
-0.020824069157242775,
0.001189707312732935,
0.05828333646059036,
-0.014383895322680473,
0.012860117480158806,
0.007846085354685783,
-0.02370643801987171,
0.03297146409749985,
0.0035175459925085306,
-0.004659514874219894,
0.012087874114513397,
0.02962314710021019,
0.009129145182669163,
-0.041871942579746246,
-0.007972737774252892,
0.013556014746427536,
0.018749073147773743,
-0.010024217888712883,
-0.002082514576613903,
-0.014737341552972794,
-0.012701170518994331,
-0.02395973913371563,
-0.032637596130371094,
-0.004816859494894743,
-0.007309458684176207,
0.0268735159188509,
0.03418924659490585,
0.0028265267610549927,
-0.003958171233534813,
0.07087049633264542,
0.024729300290346146,
0.006696048658341169,
-0.01012759655714035,
0.0024689757265150547,
-0.049337051808834076,
-0.03533247113227844,
0.02846882864832878,
-0.007657088339328766,
-0.01446738000959158,
0.012842647731304169,
-0.02373155578970909,
0.012941933237016201,
-0.011949792504310608,
-0.0003435358521528542,
0.019390642642974854,
-0.022558752447366714,
-0.007311081048101187,
0.005775623023509979,
-0.014299972914159298,
-0.00695828627794981,
-0.008982112631201744,
-0.026663925498723984,
-0.016684915870428085,
0.009298981167376041,
-0.05046536400914192,
-0.0015444220043718815,
-0.015272287651896477,
-0.015422018244862556,
0.004922929219901562,
0.025252388790249825,
-0.010081191547214985,
-0.003875785507261753,
0.02930573746562004,
-0.003701424226164818,
0.004069286398589611,
0.039376333355903625,
-0.014693125151097775,
0.002245417097583413,
-0.005731133744120598,
-0.041025616228580475,
-0.01611105166375637,
-0.013519296422600746,
0.016560660675168037,
-0.03492247685790062,
0.009557381272315979,
0.026679188013076782,
-0.0036282597575336695,
0.0023088809102773666,
0.007935287430882454,
-0.011448812671005726,
0.010515212081372738,
0.014290858060121536,
0.04265132546424866,
0.030216602608561516,
0.0064313686452806,
0.008289703167974949,
-0.009823603555560112,
0.011112015694379807,
0.0019319881685078144,
0.006052937358617783,
-0.008938749320805073,
0.046797581017017365,
-0.01459043100476265,
0.018028128892183304,
-0.023082144558429718,
-0.033501192927360535,
-0.021039064973592758,
-0.01589895971119404,
-0.02908199653029442,
0.023168031126260757,
-0.017061157152056694,
-0.013144318014383316,
-0.023509638383984566,
-0.00330017926171422,
0.01477265264838934,
0.014785696752369404,
-0.008614776656031609,
0.0012760357931256294,
-0.0038858428597450256,
0.00677630165591836,
0.015109474770724773,
0.025708897039294243,
-0.014789072796702385,
0.026177965104579926,
-0.0024212230928242207,
-0.019410450011491776,
-0.07324737310409546,
0.00656892079859972,
-0.024412984028458595,
-0.00612088106572628,
0.016192981973290443,
0.010551691055297852,
-0.017131637781858444,
0.0203985795378685,
-0.00908051896840334,
-0.005171883385628462,
0.02827899530529976,
-0.0219951830804348,
0.0023223645985126495,
-0.01316117774695158,
0.013583129271864891,
0.022707507014274597,
-0.028192272409796715,
-0.000743368174880743,
0.003278357908129692,
-0.0006094397976994514,
0.020147165283560753,
0.0262027345597744,
-0.038077306002378464,
-0.0010635610669851303,
-0.009823109954595566,
-0.07984447479248047,
-0.010802878998219967,
-0.0021827637683600187,
-0.020660273730754852,
0.00019196083303540945,
0.013158222660422325,
0.025640742853283882,
-0.007443172857165337,
-0.05726200342178345,
-0.024499794468283653,
-0.023622561246156693,
-0.007859459146857262,
0.01638932153582573,
0.008200916461646557,
-0.0021524736657738686,
-0.0024455504026263952,
0.0204668790102005,
0.04257487133145332,
-0.0006505175260826945,
-0.03226996958255768,
0.004952241666615009,
-0.016374358907341957,
-0.014272978529334068,
-0.012100167572498322,
-0.0016662601847201586,
-0.03665781766176224,
-0.025311656296253204,
0.019895173609256744,
-0.0039993347600102425,
0.010355812497437,
-0.0007930437568575144,
-0.007427654694765806,
-0.006959530524909496,
-0.04419033229351044,
-0.025082577019929886,
-0.027370139956474304,
0.015253288671374321,
0.002872160170227289,
-0.021617131307721138,
-0.01947001740336418,
-0.0019811689853668213,
0.04474279284477234,
-0.006820812821388245,
0.0252024307847023,
-0.026187635958194733,
-0.005193823017179966,
0.006054120138287544,
-0.010680031031370163,
0.01905663311481476,
-0.004655017517507076,
0.008497554808855057,
-0.019177529960870743,
-0.001332506537437439,
0.007342137396335602,
-0.0010703976731747389,
0.015239052474498749,
0.00323318294249475,
0.0166788250207901,
0.012723281979560852,
0.029228605329990387,
0.007680180482566357,
-0.014762944541871548,
-0.008312150835990906,
0.07173103094100952,
-0.06852786242961884,
0.029605954885482788,
-0.022953558713197708,
-0.0004452308639883995,
-0.001233243616297841,
-0.06270398944616318,
-0.02871019020676613,
0.012104542925953865,
-0.011669453233480453,
-0.0027747442945837975,
-0.024913206696510315,
-0.02703847363591194,
0.01495208591222763,
0.0012387200258672237,
-0.04934316128492355,
0.015371869318187237,
-0.009380931966006756,
0.003040136769413948,
-0.02706119231879711,
-0.01962762326002121,
-0.0050886329263448715,
-0.057882338762283325,
0.012314875610172749,
-0.007393711246550083,
-0.005523892119526863,
-0.03536263853311539,
0.0055632926523685455,
-0.010711447335779667,
0.005702439229935408,
-0.03612392395734787,
0.02444610185921192,
-0.0036398954689502716,
0.0260164812207222,
0.024940822273492813,
0.002358604222536087,
0.011792939156293869,
-0.0017698168521746993,
-0.0029903845861554146,
-0.004916702397167683,
-0.022973697632551193,
-0.009374864399433136,
0.009423613548278809,
-0.018135972321033478,
0.019834551960229874,
0.02208767831325531,
0.005482349079102278,
0.025099771097302437,
0.0205727256834507,
0.008573880419135094,
0.003955900203436613,
-0.006554728839546442,
0.028940830379724503,
0.010594293475151062,
0.03614901751279831,
0.06357265263795853,
-0.010593878105282784,
0.03203233331441879,
0.0021115709096193314,
-0.013852924108505249,
0.02257411740720272,
-0.009507406502962112,
0.011465663090348244,
-0.02695482224225998,
-0.0171554796397686,
0.012848797254264355,
0.020874373614788055,
-0.0220676027238369,
-0.006563388742506504,
0.02190721407532692,
0.007460922934114933,
0.030045034363865852,
0.005875981412827969,
-0.003131219884380698,
0.03135017305612564,
-0.004393123090267181,
0.025424718856811523,
0.013582204468548298,
0.002405837643891573,
0.013697581365704536,
-0.0072768330574035645,
-0.023239783942699432,
-0.004071393050253391,
-0.06922470033168793,
-0.019046250730752945,
0.014114657416939735,
0.006595252081751823,
0.005010867491364479,
-0.00008041743421927094,
0.01284940168261528,
0.0065851276740431786,
0.008066095411777496,
-0.0018146149814128876,
0.017646124586462975,
0.010775660164654255,
0.034611865878105164,
0.008399815298616886,
0.004605456255376339,
-0.029375486075878143,
0.02655002288520336,
0.014770322479307652,
-0.02308863401412964,
-0.002259260043501854,
-0.02060612104833126,
-0.03576077148318291,
0.0035098278895020485,
-0.02025921642780304,
-0.0012344568967819214,
0.001939249224960804,
0.026700150221586227,
-0.01646900549530983,
-0.02325165830552578,
-0.00018156494479626417,
-0.00009761285036802292,
0.007714903447777033,
0.0036941985599696636,
-0.014169242233037949,
0.0019713137298822403,
0.024178583174943924,
-0.01705770380795002,
0.0019384381594136357,
0.0038162542041391134,
-0.01969991624355316,
0.025382818654179573,
0.026503250002861023,
-0.025264279916882515,
-0.016958581283688545,
0.006245344877243042,
-0.034255459904670715,
-0.0017176989931613207,
0.01817253604531288,
-0.02960520051419735,
-0.0012361861299723387,
0.024220671504735947,
0.017181644216179848,
0.011130599305033684,
0.027910713106393814,
0.008264441043138504,
-0.012403364293277264,
-0.0023696566931903362,
-0.004815218038856983,
-0.014637213200330734,
-0.0032290557865053415,
-0.01355835609138012,
0.010576234199106693,
0.01958201639354229,
0.0060439943335950375,
0.020162265747785568,
0.0032163297291845083,
-0.007969075813889503,
-0.019872024655342102,
-0.0059429858811199665,
0.02034735679626465,
-0.006900527980178595,
0.0034977076575160027,
0.028978819027543068,
-0.0033530830405652523,
-0.011506212875247002,
-0.018869247287511826,
0.018525324761867523,
0.00936426967382431,
-0.027663081884384155,
-0.0067284610122442245,
-0.006150360684841871,
-0.012008688412606716,
-0.00918256863951683,
-0.02080574817955494,
0.02351963147521019,
0.002525945892557502,
0.0067863911390304565,
0.02653500810265541,
-0.020582592114806175,
-0.004727399908006191,
0.02416604571044445,
-0.04463692754507065,
-0.018166450783610344,
0.0029341713525354862,
-0.002829295117408037,
-0.022622883319854736,
0.003258657408878207,
0.022675560787320137,
-0.02041918970644474,
0.031138550490140915,
-0.01348930411040783,
-0.003031402826309204,
0.028424285352230072,
-0.004670342430472374,
0.02718527801334858,
0.005290570203214884,
-0.002329014241695404,
0.003403919283300638,
-0.038584861904382706,
-0.020989608019590378,
-0.002471993211656809,
-0.020892836153507233,
-0.01925736479461193,
0.026072140783071518,
-0.02798735909163952,
0.00004103686660528183,
0.010283250361680984,
0.01829063892364502,
-0.011733029037714005
] | [
0.6026732325553894,
0.22061333060264587,
-0.6034987568855286,
0.21205240488052368,
0.18324005603790283,
0.38874390721321106,
0.08671953529119492,
0.09930717945098877,
-0.25258055329322815,
-0.6567133069038391,
0.1628967672586441,
0.4544811248779297,
0.194048210978508,
0.44729042053222656,
-0.6067171692848206,
0.900698721408844,
0.4353307783603668,
0.40722882747650146,
-0.18264169991016388,
-0.2454507201910019,
-0.24937790632247925,
-0.05821370333433151,
0.07401640713214874,
-0.05762619152665138,
-0.23638495802879333,
-0.007620471995323896,
0.33766353130340576,
-0.16098995506763458,
0.1251118779182434,
-0.01698402501642704,
-0.3801373839378357,
0.4762478768825531,
0.12157893180847168,
-0.024835534393787384,
-0.24464930593967438,
-0.48188018798828125,
-0.014237968251109123,
0.2871023416519165,
0.36145344376564026,
-0.22472576797008514,
0.035692982375621796,
-0.20260126888751984,
-0.08458000421524048,
0.7040208578109741,
-0.2818128168582916,
-0.6688558459281921,
-1.6295543909072876,
0.7002919912338257,
-0.5822307467460632,
0.006370461080223322,
0.520627498626709,
0.014920443296432495,
0.1537143886089325,
0.5726944804191589,
-0.04199633002281189,
0.5393847227096558,
-0.15570449829101562,
0.062167227268218994,
0.34756046533584595,
-0.5060744881629944,
0.07710197567939758,
0.012840626761317253,
0.050705209374427795,
0.020726080983877182,
-0.1243218183517456,
0.27943187952041626,
0.16434039175510406,
-0.13847018778324127,
-0.5906062126159668,
-0.5100051164627075,
0.2789697051048279,
-0.1664254367351532,
-0.24898424744606018,
0.3003574311733246,
-0.09411213546991348,
0.2092226892709732,
-0.057010870426893234,
-0.20671968162059784,
0.2889493703842163,
-0.29379966855049133,
0.08246868848800659,
-0.5491468906402588,
-0.19207946956157684,
-0.22935891151428223,
0.5987001061439514,
0.03553570434451103,
-0.19469797611236572,
0.5288179516792297,
-0.4933962821960449,
-0.2745915949344635,
0.27485883235931396,
-0.2341691553592682,
0.11630851775407791,
0.5248910784721375,
0.28002461791038513,
0.4611113369464874,
0.5112051367759705,
-0.19145230948925018,
0.30145567655563354,
0.1393379122018814,
-0.37916862964630127,
-0.04192220792174339,
0.0645165890455246,
-0.12689347565174103,
-0.7479700446128845,
-0.3964402973651886,
0.2324669063091278,
-0.20060507953166962,
-0.7273706793785095,
0.43022432923316956,
-0.8274269104003906,
0.24269156157970428,
-0.04993509128689766,
0.04410868138074875,
-0.5544934272766113,
-0.00494659086689353,
0.01692085899412632,
-0.3792739510536194,
-0.08627113699913025,
0.47012239694595337,
-0.3381463587284088,
1.0641123056411743,
-0.39690732955932617,
0.2585275173187256,
0.32895562052726746,
0.3336573541164398,
0.4874933362007141,
0.47672227025032043,
-0.01599891111254692,
0.392695814371109,
0.36357200145721436,
0.48111218214035034,
-0.5589786767959595,
0.14567291736602783,
0.2155361920595169,
-0.2225489616394043,
0.4928022623062134,
0.3564532995223999,
-0.002966526197269559,
-0.08204768598079681,
-0.7912353873252869,
-0.7131782174110413,
-0.0647280290722847,
0.13596543669700623,
0.19132784008979797,
-0.6332530975341797,
0.008670376613736153,
-0.2169448286294937,
0.011234083212912083,
-0.16033266484737396,
0.15011337399482727,
-0.0966542437672615,
-0.39198341965675354,
-0.30039119720458984,
0.045477770268917084,
0.8201099038124084,
0.1099846363067627,
-0.17629402875900269,
-0.14451973140239716,
0.37574303150177,
0.3337365686893463,
0.258969783782959,
-0.3799906373023987,
-0.605018675327301,
0.7924548983573914,
-0.2848227322101593,
0.33137011528015137,
0.6601816415786743,
-0.33534833788871765,
0.19296875596046448,
-0.27009278535842896,
-0.34349027276039124,
0.045239128172397614,
-0.47108882665634155,
0.3101406991481781,
0.5552108883857727,
0.012945085763931274,
-0.2384798675775528,
0.3827384412288666,
0.24097858369350433,
-0.49758180975914,
0.21039633452892303,
0.0297097135335207,
-0.7308205366134644,
0.28992581367492676,
-0.17560145258903503,
0.03424651175737381,
-0.28269854187965393,
-0.0023962268605828285,
-0.29551616311073303,
-0.4918435513973236,
-0.49291419982910156,
0.5498618483543396,
-0.8559932708740234,
1.4717403650283813,
-0.6889769434928894,
-0.19885346293449402,
1.112951636314392,
-0.03263086453080177,
0.1375035047531128,
-0.11810135841369629,
-0.0405508354306221,
0.09860598295927048,
-0.2634020149707794,
-0.6753039360046387,
0.19233369827270508,
0.2832255959510803,
-0.3769855797290802,
-0.40340206027030945,
-0.13159479200839996,
0.6315433979034424,
-0.007396589033305645,
-0.26693397760391235,
-0.07745572179555893,
-0.19842098653316498,
0.11206721514463425,
-0.18715351819992065,
0.2287588119506836,
-0.2454177588224411,
0.33850592374801636,
0.3757757246494293,
-0.6555290222167969,
0.4523034989833832,
0.3059011697769165,
0.10911738872528076,
0.4715893566608429,
0.5834621787071228,
0.16389992833137512,
0.9015913009643555,
-0.3842146396636963,
0.10790413618087769,
0.05259966477751732,
0.3570655882358551,
-0.8621877431869507,
-0.4001575708389282,
-0.09474418312311172,
0.18905307352542877,
0.31909438967704773,
0.12285544723272324,
0.03321244567632675,
-0.28108400106430054,
0.2263125777244568,
-0.9935376048088074,
-0.13237477838993073,
-0.3963650166988373,
-0.4960363805294037,
-0.8549007773399353,
-0.03730807080864906,
-0.6999604105949402,
-0.20310445129871368,
0.041876621544361115,
0.4227210283279419,
0.2490042895078659,
-0.5218349099159241,
0.07359188795089722,
0.10824164748191833,
-0.24911676347255707,
-0.553912878036499,
0.22580161690711975,
-0.13144642114639282,
-0.06201652064919472,
0.3071766197681427,
0.20196440815925598,
-0.1456892192363739,
0.01560385711491108,
-0.3345097303390503,
-0.5106933116912842,
-0.5588229894638062,
0.8885827660560608,
0.45468035340309143,
0.6419156789779663,
0.13853570818901062,
-0.6926931142807007,
0.09629059582948685,
-0.23924590647220612,
-0.7739374041557312,
0.048717912286520004,
0.6343153715133667,
-0.8803536295890808,
-0.29571816325187683,
-0.1350688934326172,
0.32237720489501953,
0.9027647376060486,
-0.04747549071907997,
-0.2569071054458618,
-0.27074190974235535,
0.22417333722114563,
-0.1262180358171463,
-0.2741886377334595,
0.05932120978832245,
-0.28370606899261475,
0.44596385955810547,
-0.14355233311653137,
-0.5639442801475525,
0.5797366499900818,
0.6448013782501221,
0.11765513569116592,
0.10246504098176956,
0.23964212834835052,
-0.263824999332428,
0.09485122561454773,
0.5695657730102539,
0.1723211258649826,
-0.3031212091445923,
-0.09320718050003052,
0.06586203724145889,
-0.6292746067047119,
0.0872410386800766,
-5.949324131011963,
0.07852212339639664,
-0.40786877274513245,
-0.1467190980911255,
-0.2767868638038635,
-0.17159397900104523,
0.9804859161376953,
0.14752066135406494,
0.3766882121562958,
-0.3841646909713745,
0.4403698742389679,
0.1470678746700287,
-0.22388583421707153,
0.4195803105831146,
0.28118667006492615,
-0.14201681315898895,
0.2655583322048187,
-0.13398690521717072,
0.31075072288513184,
0.4958663582801819,
-0.11366410553455353,
-0.049323540180921555,
-0.05424946919083595,
0.5849759578704834,
0.2687210142612457,
0.37061992287635803,
-0.9194681644439697,
0.2031000256538391,
-0.20305143296718597,
0.012545386329293251,
0.4496324956417084,
-0.5264423489570618,
-0.09447063505649567,
-0.4221191704273224,
0.23150242865085602,
0.14529968798160553,
-0.07124882936477661,
-0.19346657395362854,
0.36574500799179077,
0.0900539979338646,
0.3581276834011078,
0.5951277613639832,
-0.16033543646335602,
-0.18179553747177124,
0.08052244037389755,
-0.13319632411003113,
0.029707560315728188,
0.24886064231395721,
0.07311439514160156,
1.0237791538238525,
-0.1155795082449913,
0.07130152732133865,
0.2637898921966553,
0.02659003995358944,
0.10374292731285095,
0.0003958524903282523,
0.1806231588125229,
0.3276166617870331,
-0.27491000294685364,
0.05225393548607826,
0.15751498937606812,
-0.459915429353714,
0.4068451523780823,
-0.47564753890037537,
-0.2561483085155487,
0.15362359583377838,
-0.8141253590583801,
-0.6534102559089661,
0.02050912193953991,
-0.06123087927699089,
-0.45831307768821716,
0.14562442898750305,
0.25956130027770996,
-0.4432319104671478,
0.08856271207332611,
-0.35412248969078064,
-0.3719281852245331,
0.17286710441112518,
0.042047783732414246,
-0.20592667162418365,
-0.32755187153816223,
-0.44174498319625854,
0.33646658062934875,
0.013022292405366898,
-0.004762011580169201,
0.10202217102050781,
-0.37227800488471985,
0.03833622857928276,
-0.32435792684555054,
0.4673716425895691,
0.6247310042381287,
-0.3918035328388214,
0.33634519577026367,
0.4605257511138916,
0.35770466923713684,
0.8358494639396667,
0.7579726576805115,
0.00891563855111599,
0.12087985128164291,
-0.0025456766597926617,
0.8237950205802917,
-0.2815001308917999,
-0.3966023623943329,
-0.8724686503410339,
-0.2980808615684509,
-0.07375860959291458,
-0.7344486117362976,
0.15339204668998718,
0.5938889384269714,
-0.8867453336715698,
0.056138668209314346,
0.01667839102447033,
-0.3217982351779938,
-0.3454441726207733,
0.579553484916687,
-0.21467643976211548,
0.18517544865608215,
0.0035750530660152435,
0.696115255355835,
-0.06903291493654251,
0.33445101976394653,
0.25914132595062256,
-0.19656939804553986,
0.1575438231229782,
0.2837803363800049,
-0.41958847641944885,
0.3271016776561737,
0.4195767045021057,
-0.642679750919342,
0.03860298916697502,
0.20739705860614777,
0.794474720954895,
-0.4781924784183502,
0.07429452240467072,
-0.08532946556806564,
-0.019559090957045555,
-0.18344131112098694,
0.032987888902425766,
0.19758303463459015,
-0.3576219379901886,
0.48573991656303406,
-0.15159471333026886,
-0.21233156323432922,
0.18303073942661285,
0.34156814217567444,
0.09962037950754166,
-0.4875127971172333,
0.2575099766254425,
0.38525497913360596,
-0.01578330807387829,
-0.03882468864321709,
0.24766495823860168,
0.3900412917137146,
-0.25542357563972473,
-0.47485581040382385,
0.02732076495885849,
0.38539111614227295,
0.06928161531686783,
-0.19313040375709534,
-0.28369784355163574,
0.2898138761520386,
-0.036702077835798264,
-1.1331145763397217,
-0.09817127883434296,
-0.031093701720237732,
-0.7536460161209106,
0.03424211964011192,
-0.3561859428882599,
-0.16270944476127625,
0.2278461456298828,
-0.05242655426263809,
-0.36192578077316284,
0.06437387317419052,
-0.22089210152626038,
0.08007919043302536,
0.030943486839532852,
-0.13831867277622223,
0.35060039162635803,
-0.11605116724967957,
-0.05566928908228874,
0.2124493271112442,
-0.5121942162513733,
-0.4861629605293274,
0.666954755783081,
1.0998461246490479,
0.6614565849304199,
0.16801773011684418,
0.05729452520608902,
-0.28428858518600464,
-0.2538745701313019,
0.17839179933071136,
-0.1314854770898819,
0.3998832702636719,
0.09339772909879684,
-0.04458308219909668,
0.16624334454536438,
0.11622700840234756,
0.42547422647476196,
0.2576700747013092,
-0.08656460791826248,
-0.07896105945110321,
0.611048698425293,
-0.22063101828098297,
0.1268678456544876,
0.37375694513320923,
-0.33941367268562317,
0.13222812116146088,
-0.3351750373840332,
-0.17704641819000244,
-0.046951793134212494,
-0.28282204270362854,
-0.5115443468093872,
-0.08511300384998322,
-0.04100142419338226,
-0.466286838054657,
0.12076369673013687,
0.32016634941101074,
0.039388928562402725,
-0.3058355152606964,
0.5538923144340515,
0.5342265367507935,
-0.14789412915706635,
-0.09849178791046143,
0.07686063647270203,
0.17210502922534943,
-0.11954723298549652,
0.7010470032691956,
-0.49039170145988464,
-0.33003225922584534,
0.12002988904714584,
-0.5282279849052429,
-0.1748969405889511,
0.1015264019370079,
-0.06217839941382408,
-0.5916686058044434,
-0.2796970009803772,
0.17825664579868317,
0.12250963598489761,
0.09185974299907684,
-0.09712348878383636,
0.5965994000434875,
0.4029799699783325,
-0.2620455026626587,
-0.6497505307197571,
0.051071733236312866,
-0.00028837178251706064,
0.33618390560150146,
-0.7322732210159302,
-0.28991323709487915,
-0.0035424556117504835,
0.22790919244289398,
-0.16253802180290222,
-0.05481058731675148,
0.094901442527771,
0.14347438514232635,
0.2564231753349304,
-0.3400730788707733,
-0.31585776805877686,
0.17807620763778687,
0.5286816954612732,
-0.012334230355918407,
-0.6007742285728455,
0.021448390558362007,
-0.5308489203453064,
-0.00213272450491786,
-0.3068825900554657,
-0.3061385154724121,
-0.32718393206596375,
0.33987322449684143,
-0.34183967113494873,
0.18584606051445007,
-0.24464933574199677,
0.6185013651847839,
0.3950594663619995,
-0.06019904464483261,
0.210250124335289,
-0.44338908791542053,
0.1401285082101822,
-0.588969886302948,
-0.06522539258003235,
-0.48150670528411865,
-0.689032793045044,
0.32153889536857605,
-0.24378357827663422,
0.24721181392669678,
-0.3103031814098358,
0.2583411633968353,
-0.07251019775867462,
0.2197980284690857,
-0.5148844718933105,
-0.3548452854156494,
-0.29654285311698914,
-0.513501763343811,
-0.540531575679779,
0.11203598976135254,
-0.031410038471221924,
0.3821066617965698,
0.5797163844108582,
0.4851874113082886,
-0.3698977530002594,
-0.4498641788959503,
0.4943189024925232,
0.5282425284385681,
-0.8503807783126831,
0.7609743475914001,
0.25068333745002747,
0.18490472435951233,
0.15339531004428864,
-0.18325723707675934,
0.26421210169792175,
0.5446109175682068,
-0.021886859089136124,
0.13472357392311096,
0.43130630254745483,
-0.1284019649028778,
0.0029893950559198856,
-0.4072885513305664,
-0.5327761173248291,
1.0116075277328491,
0.10857909917831421,
0.2088354229927063,
0.4043568968772888,
0.6169657707214355,
-0.005320939235389233,
-0.5023166537284851,
0.7274000644683838,
0.014323517680168152,
0.2573744058609009,
-0.3205110430717468,
0.16191627085208893,
0.5556631684303284,
1.0104292631149292,
-0.06556620448827744,
-0.05042323097586632,
-0.14690794050693512,
0.5277602076530457,
0.10335101932287216,
-0.4799603521823883,
-0.1746191680431366,
0.10893644392490387,
0.44472527503967285,
0.1592153161764145,
0.10354287177324295,
-0.36612609028816223,
0.04747357219457626,
0.48343756794929504,
-0.26357942819595337,
0.009336874820291996,
-0.17728005349636078,
0.35742273926734924,
0.2605013847351074,
-0.4548390805721283,
-0.33841779828071594,
0.0496135838329792,
-0.16592015326023102,
-0.02910807356238365,
0.10527531057596207,
-0.46007877588272095,
-0.7016986012458801,
0.2954126298427582,
0.07955127209424973,
0.4525797963142395,
-0.4092254042625427,
0.3670977056026459,
-0.2990438938140869,
0.23934011161327362,
0.8006001114845276,
0.3671092391014099,
0.28516095876693726,
-0.486871600151062,
-0.4166785776615143,
-0.21821865439414978,
-0.24501603841781616,
0.3085002601146698,
0.15511922538280487,
-0.677708625793457,
0.4738892912864685,
0.14268921315670013,
-0.1357356160879135,
0.15490196645259857,
-0.42227137088775635,
-0.086543008685112,
-0.5051363110542297,
-0.27817803621292114,
-0.019159242510795593,
-0.3982161581516266,
-0.1567961722612381,
0.07526592165231705,
0.16286209225654602,
0.2590772807598114,
0.2285812348127365,
-0.866584062576294,
0.2242344170808792,
0.27301889657974243,
-0.44573262333869934,
-0.239190474152565,
-0.20798072218894958,
0.6681433916091919,
0.2186158448457718,
-0.2645953297615051,
-0.2558481991291046,
0.006488218903541565,
0.2490796595811844,
0.7984441518783569,
-0.506837785243988,
0.15263903141021729,
-0.2457253336906433,
-0.43321382999420166,
-0.6627936363220215,
0.06325757503509521,
0.3251691460609436,
-0.11775757372379303,
-0.40128013491630554,
0.2771250605583191,
0.06997518241405487,
-0.0015922642778605223,
0.28087034821510315,
0.14795471727848053,
-0.06580665707588196,
-0.5044403672218323,
0.1963939070701599,
-0.5512592792510986,
0.6622572541236877,
-0.1805044710636139,
-0.04277865216135979,
-0.35332030057907104,
-0.000033564516343176365,
0.7046576142311096,
-0.04571061581373215,
0.41566863656044006,
-0.5775965452194214,
0.12423869967460632,
-0.31961262226104736,
0.4710609018802643,
-0.37693554162979126,
0.15122264623641968,
0.3233114778995514,
-0.07158327102661133,
0.014315096661448479,
-0.24550648033618927,
-0.35273823142051697,
-0.46644115447998047,
0.2771887481212616,
0.4614354372024536,
-0.014124145731329918,
0.47681885957717896,
0.0824587419629097,
-0.10614840686321259,
-0.6378213167190552,
0.24106526374816895,
-0.23049642145633698,
-0.15956050157546997,
-0.1032838299870491,
-0.08916646242141724,
-0.5955081582069397,
-0.17540457844734192,
0.05753837153315544,
-0.774023175239563,
-0.14382939040660858,
-0.08669278025627136
] |
Combination of peginterferon and ribavirin is the current therapy for chronic hepatitis C infection (HCV). Interstitial pneumonitis is a rare side-effect of HCV therapy and is an important cause of dose reduction or discontinuation, impairing success of antiviral therapy. We performed a review of the literature in order to present diagnostic modalities and possible treatments for pneumonitis and to offer guidelines. We searched for cases where pneumonitis as a side-effect of HCV treatment was documented. First we performed a literature search via PubMed and Web of Science interface and second we searched three drug toxicity databases. We systematically analyzed all case reports with respect to clinical manifestations, type of treatment, and outcome. A literature search revealed 19 articles, containing 25 case descriptions, while we traced 33 cases from the drug toxicity databases. Pneumonitis presented with any of the combination of fever, dyspnea, and cough and can arise with any type of (conventional or pegylated) interferon. Mortality secondary to pneumonitis was seen in 7% of cases, exclusively with peginterferon α-2b. In most cases therapy was discontinued and steroids were started. Interferon-induced pneumonitis during HCV treatment is a severe complication and should be recognized in order to prevent further pulmonary damage and/or death. | [
0.011418387293815613,
0.0051706936210393906,
-0.017369821667671204,
0.0182502381503582,
-0.015062140300869942,
-0.006147751584649086,
0.00806243997067213,
0.018432140350341797,
-0.01668870821595192,
0.005839829333126545,
-0.015327155590057373,
0.020172208547592163,
-0.003063707612454891,
0.006371807772666216,
-0.007987688295543194,
0.012782778590917587,
-0.010853393003344536,
0.025502821430563927,
0.011822165921330452,
-0.011554800905287266,
-0.0034873185213655233,
0.016043365001678467,
0.007875686511397362,
-0.003674354637041688,
0.008630068972706795,
0.004644629545509815,
0.015345285646617413,
-0.008048217743635178,
0.0026160646229982376,
-0.0015559308230876923,
-0.002727626357227564,
-0.00506560318171978,
0.01774633303284645,
0.010889949277043343,
-0.004391195252537727,
0.02111666090786457,
-0.005466792732477188,
0.022822879254817963,
0.02205044776201248,
-0.0037782329600304365,
0.0071846721693873405,
-0.008577939122915268,
0.0038201031275093555,
-0.015388261526823044,
-0.0030364240519702435,
-0.0067623937502503395,
0.0016738615231588483,
0.0029092421755194664,
0.018479259684681892,
0.0032764740753918886,
-0.0017345008673146367,
-0.002909979782998562,
-0.01048808079212904,
-0.0019938501063734293,
-0.0053243678994476795,
-0.012038995511829853,
0.015820275992155075,
-0.012158111669123173,
-0.005704708397388458,
-0.010813078843057156,
0.016805481165647507,
-0.005246685352176428,
-0.009685462340712547,
-0.006890180520713329,
0.009907089173793793,
-0.06650160253047943,
-0.00615291204303503,
0.033325184136629105,
0.005179286003112793,
0.022738806903362274,
0.01246359571814537,
0.014408061280846596,
0.016296546906232834,
0.01845904067158699,
0.022534769028425217,
0.011600648052990437,
0.007710161618888378,
0.03558995574712753,
0.024298086762428284,
-0.022383758798241615,
0.0010374225676059723,
-0.002764953300356865,
-0.004960346035659313,
0.023716280236840248,
0.006691754795610905,
0.014975300058722496,
-0.018176592886447906,
-0.014133522287011147,
0.012501051649451256,
-0.02475903183221817,
-0.022641154006123543,
-0.022844672203063965,
-0.028442848473787308,
-0.0155878234654665,
0.002665860578417778,
-0.021033717319369316,
-0.014244216494262218,
0.0024001281708478928,
-0.008602363988757133,
0.005876693408936262,
-0.024651965126395226,
0.006508364342153072,
0.019096795469522476,
0.000661069992929697,
-0.019361477345228195,
0.006854989565908909,
0.0019704438745975494,
0.028314629569649696,
0.026968464255332947,
0.009783638641238213,
0.0015335188945755363,
0.016080675646662712,
0.053286854177713394,
0.024423792958259583,
0.002206750214099884,
-0.014735622331500053,
0.022093094885349274,
0.0006161574274301529,
0.006947987712919712,
0.016146913170814514,
0.022045139223337173,
-0.011611375957727432,
0.006825464777648449,
-0.0040931738913059235,
0.00535817164927721,
-0.004144622012972832,
-0.012150396592915058,
-0.003097261767834425,
-0.015426895581185818,
-0.015918122604489326,
-0.004284810274839401,
0.005591176450252533,
-0.01825462281703949,
-0.033463627099990845,
0.01348952017724514,
-0.0014528902247548103,
0.0004189735045656562,
-0.018456116318702698,
-0.008770754560828209,
-0.026702236384153366,
-0.014823381789028645,
0.005772260949015617,
-0.0019211366306990385,
0.012990301474928856,
0.008776256814599037,
0.000787676777690649,
0.010428696870803833,
0.006717284210026264,
0.007718880660831928,
-0.0014396337792277336,
-0.006125336512923241,
0.01210001390427351,
-0.041485726833343506,
-0.010855190455913544,
-0.0033477002289146185,
0.004235283471643925,
0.002526742871850729,
0.02070600911974907,
0.0034584528766572475,
0.006718393415212631,
0.01639493741095066,
-0.025692341849207878,
0.0009575784206390381,
0.008159836754202843,
0.033307552337646484,
-0.0027953097596764565,
-0.011939738877117634,
-0.004518749658018351,
0.02567182295024395,
0.0039146458730101585,
-0.012147914618253708,
-0.0051921759732067585,
-0.009004302322864532,
0.013998985290527344,
0.01742572709918022,
-0.002024195622652769,
0.02062852494418621,
0.0029100016690790653,
-0.006569903809577227,
0.06575237214565277,
-0.016490185633301735,
0.011168823577463627,
-0.016739066690206528,
0.005654926411807537,
0.002612893469631672,
0.0034534467849880457,
0.010681994259357452,
-0.0042282287031412125,
0.027983959764242172,
-0.03209073096513748,
-0.016935359686613083,
-0.0242304727435112,
-0.011265668086707592,
0.011884503066539764,
0.018891995772719383,
0.0026484476402401924,
0.01823270134627819,
0.028032870963215828,
-0.003304785117506981,
0.02278970554471016,
0.02173822559416294,
0.005342511460185051,
0.0014596674591302872,
0.020948348566889763,
-0.011832352727651596,
0.020737003535032272,
0.008320232853293419,
-0.009927822276949883,
-0.021221091970801353,
-0.013182500377297401,
0.013050983659923077,
-0.006805587559938431,
0.010560781694948673,
-0.0008620759472250938,
0.016398584470152855,
0.015524429269134998,
0.005102370399981737,
0.023396331816911697,
-0.027463814243674278,
-0.0116085484623909,
0.006849181838333607,
0.024554837495088577,
-0.012970701791346073,
-0.005020610056817532,
0.014120560139417648,
-0.022068459540605545,
0.014512350782752037,
0.01134524866938591,
0.01486187893897295,
0.014181915670633316,
-0.037813857197761536,
-0.016013706102967262,
-0.015097207389771938,
-0.032525040209293365,
0.01819767989218235,
-0.015474336221814156,
0.009830758906900883,
-0.01529567502439022,
0.009344391524791718,
-0.023859122768044472,
-0.009912488982081413,
-0.012008078396320343,
0.005501010455191135,
0.0013684474397450686,
-0.0019484723452478647,
0.005620533600449562,
0.0012085163034498692,
-0.01979510858654976,
0.010991094633936882,
-0.024848172441124916,
0.0077745346352458,
0.0018794257193803787,
-0.028527716174721718,
-0.0023064054548740387,
0.001986968796700239,
-0.009153682738542557,
0.00840481836348772,
-0.006852409802377224,
0.024329930543899536,
0.04169520363211632,
0.009788054041564465,
0.005963459145277739,
-0.03537200391292572,
0.0011425677221268415,
0.00854046456515789,
0.033297017216682434,
-0.0035674816463142633,
-0.007020376622676849,
-0.004070362076163292,
0.005465909373015165,
0.007140796631574631,
-0.006917709484696388,
-0.02119290642440319,
-0.08045715093612671,
-0.008868593722581863,
-0.024193694815039635,
-0.016139037907123566,
0.008046556264162064,
-0.013059653341770172,
-0.0044603291898965836,
0.012891137972474098,
-0.000997551716864109,
0.012060435488820076,
-0.01683748885989189,
0.010511426255106926,
0.00015924999024719,
0.02510012686252594,
-0.023954369127750397,
-0.0025758501142263412,
0.006966778077185154,
-0.007396487053483725,
-0.009016836062073708,
-0.0011818360071629286,
-0.00790475681424141,
0.006698688492178917,
0.011372176930308342,
-0.0032216194085776806,
0.02898862212896347,
0.042136721312999725,
0.010449938476085663,
-0.005012409761548042,
-0.01342734880745411,
0.006059855222702026,
0.004190873820334673,
0.0024326439015567303,
0.015186671167612076,
0.007915906608104706,
0.0019972380250692368,
-0.003630903083831072,
-0.009072795510292053,
0.01251211017370224,
-0.009376008063554764,
0.009365328587591648,
-0.018126539885997772,
0.010568898171186447,
0.02533469721674919,
-0.006505565717816353,
0.0014985594898462296,
-0.01712501049041748,
0.02144172042608261,
0.009437980130314827,
0.012737434357404709,
0.01017404068261385,
-0.0077750710770487785,
-0.0036430684849619865,
-0.0024965894408524036,
0.026837412267923355,
-0.0007966677658259869,
-0.035432495176792145,
-0.009369791485369205,
0.041411083191633224,
-0.0015484212199226022,
-0.004100503399968147,
0.004338513128459454,
0.004863492213189602,
-0.012299763970077038,
0.000021299347281455994,
-0.018023785203695297,
0.00472494401037693,
0.008169823326170444,
-0.003691317979246378,
-0.0140323955565691,
0.009062308818101883,
-0.016616469249129295,
0.012313018552958965,
-0.016161391511559486,
-0.012842493131756783,
0.021829459816217422,
0.004711597692221403,
-0.015091393142938614,
-0.005175923928618431,
-0.0023414092138409615,
-0.006909377407282591,
-0.01341261900961399,
-0.0037111006677150726,
0.008979471400380135,
0.0033191493712365627,
-0.01062094047665596,
-0.001877348404377699,
0.009384063072502613,
0.006375779863446951,
0.02071288973093033,
-0.01906120404601097,
0.013403388671576977,
0.02768818475306034,
-0.035851266235113144,
0.011769026517868042,
-0.026428354904055595,
-0.020211931318044662,
-0.010582385584712029,
0.012555320747196674,
0.021402642130851746,
0.006226647179573774,
-0.01161116361618042,
-0.010927273891866207,
-0.014783521182835102,
-0.0076571861281991005,
-0.020655322819948196,
0.013143934309482574,
-0.004099322482943535,
-0.020807303488254547,
-0.01875457912683487,
-0.0015131672844290733,
0.015700023621320724,
-0.012070359662175179,
-0.011211825534701347,
0.019926030188798904,
0.008649532683193684,
0.043202899396419525,
0.024959160014986992,
0.0012495918199419975,
0.0714438259601593,
0.013236535713076591,
-0.011704439297318459,
0.010453406721353531,
-0.007159254979342222,
-0.0005497146630659699,
-0.021575938910245895,
0.0029517291113734245,
0.0158357135951519,
-0.014366455376148224,
0.011701489798724651,
-0.009990437887609005,
-0.011925303377211094,
-0.005963485687971115,
0.0034781694412231445,
-0.00956227071583271,
0.0007649599574506283,
-0.028998717665672302,
0.02227899804711342,
0.006385041866451502,
0.01035695243626833,
-0.003434946294873953,
0.0064066313207149506,
-0.009553655050694942,
-0.005222013220191002,
-0.005687057971954346,
0.0021269163116812706,
-0.011184968054294586,
-0.024772703647613525,
0.004065267741680145,
-0.02531909942626953,
-0.051773346960544586,
-0.006377125158905983,
-0.02236214093863964,
0.03461143746972084,
-0.03293857350945473,
-0.036048129200935364,
-0.02770138904452324,
-0.0008645909838378429,
-0.009408889338374138,
0.0008646342903375626,
-0.01526868250221014,
-0.02043543942272663,
0.012330282479524612,
-0.024982089176774025,
0.03957736864686012,
-0.0042289067059755325,
-0.005001279059797525,
-0.00957705918699503,
-0.035428181290626526,
-0.006763075478374958,
0.0040334840305149555,
0.013495082966983318,
0.01575310155749321,
0.003285931423306465,
-0.011064624413847923,
-0.006190531421452761,
-0.01521223969757557,
0.023340806365013123,
-0.0008134723175317049,
0.027742234990000725,
-0.0931830108165741,
-0.03870251029729843,
-0.0015809761825948954,
0.013075502589344978,
-0.018831836059689522,
-0.0031705033034086227,
0.012992835603654385,
-0.008522504940629005,
-0.011959612369537354,
-0.007824289612472057,
-0.0011726794764399529,
-0.016358084976673126,
0.007610988337546587,
-0.03357089310884476,
0.034401241689920425,
0.014862259849905968,
-0.019168205559253693,
0.00932947639375925,
-0.02915295772254467,
0.011492779478430748,
0.04096243157982826,
0.04396556317806244,
-0.018113862723112106,
0.007183492183685303,
-0.0001647304743528366,
-0.0053259399719536304,
-0.07433697581291199,
-0.03073137439787388,
-0.022387808188796043,
-0.003613770939409733,
0.012420235201716423,
0.011523386463522911,
-0.017099350690841675,
0.0018488680943846703,
-0.006064712069928646,
-0.005487230606377125,
-0.022998902946710587,
0.015004237182438374,
0.01170236337929964,
-0.009391695261001587,
0.00994664616882801,
0.016208278015255928,
-0.02635272406041622,
0.0063975295051932335,
-0.004130047280341387,
-0.012607821263372898,
-0.015283079817891121,
-0.012981362640857697,
-0.029722273349761963,
0.003077392466366291,
0.004562694113701582,
-0.08031925559043884,
-0.002907385118305683,
-0.004570282530039549,
-0.014630456455051899,
-0.0075823357328772545,
-0.033582985401153564,
0.04645612835884094,
-0.021631646901369095,
0.0017874273471534252,
-0.015079835429787636,
0.005758026614785194,
-0.0003996796440333128,
-0.013145663775503635,
0.007678335532546043,
0.019818514585494995,
-0.011197643354535103,
0.032316409051418304,
0.03104018233716488,
0.005453361198306084,
-0.04744000360369682,
0.008838839828968048,
-0.006005913484841585,
-0.007887103594839573,
-0.0026291068643331528,
-0.005449796095490456,
-0.015922769904136658,
-0.012439858168363571,
0.01738823391497135,
-0.012873794883489609,
-0.019549012184143066,
-0.010515425354242325,
-0.009374821558594704,
-0.02069856971502304,
0.004485727287828922,
0.008912576362490654,
-0.00405530072748661,
0.012836861424148083,
0.012049420736730099,
-0.00446190033107996,
-0.019219042733311653,
-0.0018441778374835849,
0.02628001756966114,
0.005691980477422476,
-0.01173098012804985,
0.0004940526559948921,
-0.0065014297142624855,
0.0035314057022333145,
-0.012406904250383377,
0.019970880821347237,
-0.029989883303642273,
0.0013479507761076093,
-0.002745123580098152,
0.02035379596054554,
-0.02994580566883087,
0.03789801895618439,
-0.013957480899989605,
-0.008041447028517723,
-0.003444479778409004,
0.025652844458818436,
0.01980896107852459,
-0.010614774189889431,
-0.004807102493941784,
-0.008157800883054733,
0.07061954587697983,
-0.020782586187124252,
0.02925751730799675,
-0.02722756937146187,
-0.012831046245992184,
0.005253208335489035,
0.017104582861065865,
0.002933511510491371,
-0.015963898971676826,
-0.0131682138890028,
-0.008834922686219215,
-0.014324937015771866,
-0.0200148057192564,
0.007086347788572311,
-0.009310574270784855,
0.004611669108271599,
-0.004762586206197739,
-0.0025436286814510822,
-0.016744527965784073,
0.023144708946347237,
-0.005137128755450249,
-0.0018821381963789463,
-0.025172505527734756,
-0.008918647654354572,
0.015152412466704845,
-0.0037820434663444757,
-0.026900077238678932,
0.015433182939887047,
-0.022660449147224426,
0.003967706114053726,
-0.004041321575641632,
0.0013611065223813057,
0.0009110593236982822,
0.012959771789610386,
-0.0088607557117939,
-0.015387605875730515,
-0.018273742869496346,
0.011974731460213661,
0.011172120459377766,
0.00761784054338932,
0.011680146679282188,
0.0100041963160038,
-0.0064362953417003155,
-0.019173555076122284,
0.05651836842298508,
-0.0048818732611835,
0.003661142662167549,
0.014466272667050362,
0.00654779514297843,
0.004015810787677765,
-0.009336905553936958,
0.00438930606469512,
-2.5704503059387207e-7,
-0.010175289586186409,
0.018360266461968422,
-0.004318648017942905,
-0.01533596497029066,
0.014531753025949001,
0.00006668269634246826,
-0.005327938124537468,
0.001120151486247778,
-0.018249504268169403,
-0.0187379103153944,
-0.02050229161977768,
0.022860050201416016,
0.016155244782567024,
0.02261188067495823,
-0.021778928115963936,
-0.03799651563167572,
0.017863169312477112,
-0.014275497756898403,
-0.00521462969481945,
0.007953202351927757,
-0.007122281938791275,
0.027409963309764862,
0.0216982401907444,
-0.007458619773387909,
0.009337544441223145,
0.01214737817645073,
-0.00502247828990221,
-0.001738139078952372,
-0.055500708520412445,
0.009056512266397476,
-0.009609902277588844,
0.007378392852842808,
-0.03717081993818283,
0.01879820227622986,
-0.012764161452651024,
0.0012158602476119995,
0.013314738869667053,
0.0281849168241024,
0.01200252864509821,
-0.001405109534971416,
0.011693941429257393,
0.004692286252975464,
0.03397750109434128,
-0.000550529221072793,
0.001920110546052456,
-0.028510063886642456,
0.0017845637630671263,
-0.00553285563364625,
-0.023282287642359734,
-0.03564372658729553,
0.011743631213903427,
0.0023300149478018284,
-0.012731418013572693,
0.010043124668300152,
-0.007835433818399906,
-0.019301965832710266,
0.0016960452776402235,
0.003127308562397957,
-0.014264898374676704,
0.015756290405988693,
0.02288307622075081,
0.008136864751577377,
0.0019608999136835337,
0.00039908982580527663,
0.018451521173119545,
-0.009344775229692459,
-0.01026766374707222,
-0.007805129513144493,
0.013997919857501984,
0.025252055376768112,
0.011653168126940727,
-0.022097913548350334,
-0.023556135594844818,
-0.01424489077180624,
-0.012037742882966995,
-0.005456625483930111,
0.010654108598828316,
0.023621506989002228,
0.002001074841246009,
-0.01636476442217827,
0.039099205285310745,
0.0003036772832274437,
0.015713676810264587,
-0.009222856722772121,
0.021015752106904984,
-0.015392915345728397,
0.012109454721212387,
0.010689851827919483,
-0.019930774345993996,
0.00001283490564674139,
-0.044486649334430695,
0.00983236264437437,
-0.03523622453212738,
-0.02081085368990898,
-0.00858947541564703,
0.008274516090750694,
-0.0001810360699892044,
-0.007740415632724762,
-0.007768653333187103,
-0.0064497957937419415,
-0.007365926168859005,
0.05109783262014389,
0.014783870428800583,
-0.0010231329360976815,
-0.016724910587072372,
0.0032001512590795755,
-0.0014332686550915241,
-0.02314145863056183,
-0.03365648537874222,
0.007394819054752588,
0.024827301502227783,
0.0050354585982859135,
-0.0028270799666643143,
-0.012106706388294697,
0.014548911713063717,
-0.0035243998281657696,
-0.0039098504930734634,
0.023289335891604424,
-0.010871540755033493,
-0.0006575987208634615,
0.025111928582191467,
-0.04423554986715317,
-0.010947734117507935,
0.012757685966789722,
0.012400857172906399,
-0.004077832214534283,
0.02102028951048851,
0.019297420978546143,
0.005349299870431423,
0.002894013887271285,
-0.006009641569107771,
-0.01512310653924942,
-0.004181776195764542,
-0.017919136211276054,
-0.007730415090918541,
0.0060778651386499405,
0.01447042915970087,
-0.012987129390239716,
0.018720369786024094,
-0.002360562328249216,
0.018689844757318497,
0.026784051209688187,
0.0006397150573320687,
-0.012750478461384773,
-0.0043471320532262325,
-0.0006257800851017237,
0.025731869041919708,
0.0008474430069327354,
-0.015691660344600677
] | [
0.20418505370616913,
-0.15654397010803223,
0.3288426399230957,
-0.17145207524299622,
-0.07802483439445496,
-0.10820112377405167,
0.1527608186006546,
-0.3106449246406555,
-0.15492317080497742,
-0.23172268271446228,
0.3431621789932251,
0.38394787907600403,
-0.41684144735336304,
0.14343972504138947,
-0.1457192599773407,
0.8099063038825989,
0.6000094413757324,
0.20317605137825012,
-0.18963192403316498,
-0.6764898300170898,
0.04176933690905571,
-0.5675060749053955,
0.17191772162914276,
-0.13492611050605774,
0.04280412197113037,
0.39039331674575806,
0.2851756513118744,
0.14957934617996216,
0.14946527779102325,
-0.09108762443065643,
0.2107492983341217,
0.44814246892929077,
-0.15698760747909546,
-0.5510256886482239,
0.4325902462005615,
0.6977881789207458,
-0.023088660091161728,
-0.1368153989315033,
-0.06049129739403725,
-0.6513181328773499,
-0.22169233858585358,
0.024431167170405388,
-0.0674600899219513,
0.6267091631889343,
0.1779039204120636,
-0.19952069222927094,
-1.2446155548095703,
0.4397546648979187,
-0.2834300398826599,
0.10412714630365372,
-0.3259884715080261,
-0.06639416515827179,
0.26901981234550476,
0.22314345836639404,
0.6850574612617493,
0.3589613139629364,
-0.8822992444038391,
-0.27795350551605225,
0.04882758855819702,
-0.07059871405363083,
-0.6806977987289429,
0.2116367220878601,
-0.07858762890100479,
-0.0050004455260932446,
0.07805970311164856,
0.42223477363586426,
-0.04001985117793083,
0.009025889448821545,
-0.3717973828315735,
-0.3061482608318329,
0.4166375696659088,
-0.29440176486968994,
-0.4271409809589386,
0.048758797347545624,
0.3027016520500183,
-0.2559637129306793,
-0.3498441278934479,
-0.31395259499549866,
0.42836034297943115,
0.13633154332637787,
0.33466148376464844,
0.09215355664491653,
-0.12352163344621658,
-0.23630385100841522,
0.41871076822280884,
0.29906684160232544,
-0.08859290927648544,
0.7786601781845093,
-0.3316384553909302,
0.07773397862911224,
-0.102300263941288,
0.23390881717205048,
0.05426933243870735,
0.15741321444511414,
-0.03591874986886978,
-0.4156948924064636,
-0.23794101178646088,
0.052048105746507645,
0.07715844362974167,
0.1720166951417923,
0.10415346175432205,
-0.1723708212375641,
0.12385519593954086,
-0.3991793990135193,
0.3821219205856323,
-0.32816413044929504,
-0.26621952652931213,
-0.9315407872200012,
-0.5804599523544312,
0.33944961428642273,
-0.692876935005188,
0.18832415342330933,
0.5330848693847656,
-0.23090384900569916,
-0.1975545734167099,
-0.1563454419374466,
0.640347957611084,
0.0004580728127621114,
-0.2829872965812683,
0.08428250253200531,
-0.14163462817668915,
1.2412536144256592,
-0.237702414393425,
0.4456881582736969,
0.1893053948879242,
0.12375763803720474,
0.3528861701488495,
0.22452190518379211,
-0.39607205986976624,
0.37551820278167725,
0.24315446615219116,
0.6313488483428955,
-0.3433550298213959,
-0.2505432069301605,
0.34900280833244324,
-0.55036860704422,
-0.22394657135009766,
0.0944264754652977,
0.41751009225845337,
0.3385528028011322,
-0.23997367918491364,
0.05074487254023552,
-0.04592050239443779,
-0.1127542108297348,
0.06815875321626663,
0.05804455652832985,
0.018283024430274963,
0.14998090267181396,
0.3274523913860321,
0.09967970848083496,
0.005817214492708445,
0.08947436511516571,
-0.291730672121048,
0.0862923189997673,
-0.3515793979167938,
0.07887747883796692,
0.1411903351545334,
-0.30823734402656555,
-0.5929371118545532,
-0.19327722489833832,
0.5777069926261902,
-0.04149675741791725,
-0.2550501823425293,
-0.07325606048107147,
0.3119767904281616,
0.006690928712487221,
-0.26048392057418823,
0.3860631287097931,
0.49081167578697205,
0.06607100367546082,
-0.45064103603363037,
-0.47275111079216003,
-0.21386031806468964,
-0.6479888558387756,
0.2144131064414978,
-0.20156940817832947,
0.19196876883506775,
0.23173154890537262,
0.15755431354045868,
-0.08008389174938202,
-0.47183507680892944,
0.3229677081108093,
-0.324346661567688,
-0.687656819820404,
0.41988030076026917,
0.6419001221656799,
0.7607910633087158,
0.061673447489738464,
0.3605788052082062,
0.558765709400177,
-0.11059799790382385,
0.1764533519744873,
0.2383779138326645,
-0.4026957154273987,
1.417166829109192,
-0.16694875061511993,
-0.6558505892753601,
1.208849310874939,
0.08227896690368652,
-0.09659969061613083,
-0.2797193229198456,
0.6920257210731506,
0.42131248116493225,
-0.20707905292510986,
-1.1252331733703613,
-0.04872196540236473,
0.08004838228225708,
0.03736671060323715,
0.09633275866508484,
0.21019405126571655,
1.0199123620986938,
-0.6751772165298462,
-0.35454481840133667,
-0.17078712582588196,
0.26561033725738525,
-0.22491002082824707,
0.47875574231147766,
0.4246247112751007,
-0.124897800385952,
0.2912328839302063,
0.3724459111690521,
-0.8693809509277344,
0.31848573684692383,
0.95185786485672,
-0.09524703770875931,
1.0545573234558105,
-0.080202616751194,
0.030535859987139702,
0.04565344750881195,
0.04395538941025734,
0.6489042043685913,
0.020100180059671402,
0.5537592172622681,
-0.16953562200069427,
-0.09947994351387024,
-0.0038302838802337646,
-0.26934540271759033,
-0.5004234313964844,
-0.04657067358493805,
-0.023477129638195038,
0.11989215761423111,
0.23045285046100616,
-0.6311162710189819,
0.198674276471138,
0.11123228073120117,
-0.1992613822221756,
-0.5084677934646606,
0.20602640509605408,
-0.2594742178916931,
-0.7478092908859253,
0.4871878921985626,
0.1450808048248291,
0.25409722328186035,
-0.1568448543548584,
0.615257978439331,
-0.03787185624241829,
-0.41756919026374817,
0.012317055836319923,
0.08559650927782059,
-0.30749034881591797,
-0.35261452198028564,
0.49937042593955994,
0.48608481884002686,
-0.19447557628154755,
-0.35601556301116943,
-0.2533465325832367,
-0.6473674178123474,
-0.09624695777893066,
0.428758442401886,
0.18912555277347565,
0.5740264654159546,
0.17506690323352814,
-1.0389444828033447,
-0.10996503382921219,
-0.29123762249946594,
-0.06354820728302002,
0.12175007164478302,
0.709494948387146,
-0.9464127421379089,
-0.6155047416687012,
-0.20545224845409393,
0.48784229159355164,
0.769658088684082,
0.3299257755279541,
-0.8992064595222473,
-0.4700351059436798,
-0.18894460797309875,
-0.5079578161239624,
-0.5964837074279785,
-0.16273464262485504,
0.19510698318481445,
0.6539705395698547,
-0.46791785955429077,
-0.04645751789212227,
-0.017278354614973068,
0.08052345365285873,
-0.12186813354492188,
0.6468924283981323,
0.683981716632843,
-0.38552019000053406,
0.15174810588359833,
0.1796761304140091,
-0.34666386246681213,
0.1803809553384781,
0.0692567378282547,
-0.5219728350639343,
-0.12890759110450745,
-0.10911903530359268,
-5.791558265686035,
0.040792886167764664,
-0.47941169142723083,
-0.10866320133209229,
0.5002944469451904,
-0.11741196364164352,
1.0175843238830566,
-0.30013012886047363,
0.41443687677383423,
0.5026921629905701,
0.0776490569114685,
0.7677627801895142,
0.6046178340911865,
-0.15873399376869202,
0.08181107044219971,
0.32868319749832153,
-0.49212881922721863,
-0.12571078538894653,
0.896377682685852,
-0.05394364520907402,
1.1673462390899658,
-0.1233130395412445,
-0.22833140194416046,
0.7854631543159485,
-0.3416230380535126,
-0.20128867030143738,
-0.8957396745681763,
0.7752051949501038,
-0.28552860021591187,
-0.07892429083585739,
0.5049451589584351,
-0.21278944611549377,
0.4000748097896576,
-0.22585900127887726,
0.15705905854701996,
-0.03989700600504875,
0.5669878125190735,
-0.2844165861606598,
-0.10810650140047073,
-0.5265418887138367,
0.384073406457901,
0.2918344736099243,
0.21917425096035004,
-0.22218945622444153,
0.2708075940608978,
-0.12275011092424393,
0.1595962941646576,
-0.01659105345606804,
-0.1545282006263733,
1.081295371055603,
0.23860710859298706,
-0.336124986410141,
0.37351903319358826,
0.2983417809009552,
0.0051859100349247456,
-0.3179764747619629,
-0.5824111104011536,
0.0828114002943039,
-0.1743602454662323,
0.6612286567687988,
-0.3162069320678711,
-0.06784408539533615,
-0.4753614366054535,
-0.5854280591011047,
-0.23806102573871613,
-0.15713974833488464,
-0.5648819804191589,
-0.3890857398509979,
0.45973995327949524,
-0.12206994742155075,
-0.5055738687515259,
0.28480789065361023,
0.05450301989912987,
-0.5212974548339844,
0.7383629083633423,
-0.06332457810640335,
0.4017864167690277,
-0.07299592345952988,
-0.29527145624160767,
0.14906471967697144,
-0.44776445627212524,
-0.7312217950820923,
0.3446060121059418,
0.07947445660829544,
0.637706458568573,
-0.05793796107172966,
-0.5084728598594666,
-0.25685831904411316,
-0.45627954602241516,
-0.024904441088438034,
0.31996265053749084,
-0.6817606687545776,
0.1744668334722519,
0.1203092411160469,
-0.4015209972858429,
0.6201157569885254,
-0.023427443578839302,
0.6971724629402161,
0.4397129416465759,
0.26922833919525146,
0.9655190110206604,
0.12473364174365997,
0.0465255044400692,
-0.9216002821922302,
0.21728232502937317,
-0.1787787824869156,
0.08297543972730637,
-0.2727031409740448,
0.4398333728313446,
-0.7002836465835571,
0.20611245930194855,
0.3337608277797699,
-0.23207391798496246,
-0.05763527378439903,
0.4228026568889618,
-0.36963486671447754,
-0.36289873719215393,
-0.20052817463874817,
0.05761496350169182,
-0.13583330810070038,
0.17407485842704773,
0.4198358356952667,
-0.02490970678627491,
0.042834099382162094,
-0.14972321689128876,
-0.6869451999664307,
-0.16963918507099152,
0.6202201843261719,
-0.2721281051635742,
0.4423016607761383,
-0.12031668424606323,
0.2680792808532715,
-0.4585365951061249,
-0.4451545774936676,
0.03129399195313454,
-0.6012140512466431,
-0.9564902186393738,
0.7023863196372986,
0.10141763836145401,
-0.11134858429431915,
0.09924722462892532,
-0.42462143301963806,
-0.6542505621910095,
-0.0066924127750098705,
-0.1264384388923645,
0.07063644379377365,
-0.2975142002105713,
-0.03927468881011009,
-0.6133621335029602,
-0.14669695496559143,
0.38271287083625793,
-0.04822880029678345,
-0.0044720713049173355,
0.32754263281822205,
0.06995729357004166,
0.2575431764125824,
0.6505301594734192,
0.6784613728523254,
0.27721989154815674,
-0.6561513543128967,
0.055426307022571564,
0.17143197357654572,
-1.1539450883865356,
-0.020943082869052887,
-0.014727913774549961,
-0.22166408598423004,
-0.0756264328956604,
-0.24716852605342865,
0.1811426281929016,
-0.02384290285408497,
-0.1802421659231186,
-0.34400278329849243,
-0.24264299869537354,
0.07835472375154495,
0.23980607092380524,
0.6779724359512329,
-0.6205294132232666,
-0.18624772131443024,
-0.5294944047927856,
0.08779297769069672,
0.25347408652305603,
-0.7317641973495483,
-0.146338552236557,
0.44832363724708557,
0.3984432816505432,
-0.5506559014320374,
-0.15834364295005798,
-0.6323021650314331,
-0.2215185910463333,
-0.5514345765113831,
0.3584127426147461,
0.10466063767671585,
0.3710295855998993,
-0.21456918120384216,
-0.06462039053440094,
-0.32822561264038086,
-0.20629769563674927,
0.3440638780593872,
-0.006349503993988037,
-0.3557651937007904,
-0.26845401525497437,
1.2958810329437256,
-0.19173821806907654,
0.3449751138687134,
0.5637147426605225,
-0.5827426910400391,
-0.03603997826576233,
0.07765872776508331,
0.07020340114831924,
-0.4078933298587799,
-0.08295943588018417,
-0.592817485332489,
0.3755953013896942,
0.5105857849121094,
-0.4499607980251312,
0.3813539147377014,
0.3562304377555847,
-0.28071823716163635,
-0.2168303281068802,
0.31909841299057007,
0.5734246969223022,
-0.35280463099479675,
0.04130358621478081,
0.14122842252254486,
-0.5394847393035889,
0.5730860829353333,
0.3694861829280853,
-0.8509811162948608,
0.46043357253074646,
0.4272545874118805,
0.09471550583839417,
-0.22117549180984497,
-0.22353769838809967,
0.18823987245559692,
-0.06054173782467842,
0.15172281861305237,
-0.9150656461715698,
0.22847095131874084,
-0.18319407105445862,
0.15016889572143555,
-0.3262423872947693,
0.19634795188903809,
-0.14966925978660583,
0.18484783172607422,
-0.439215749502182,
0.46724116802215576,
0.5097959041595459,
-0.42618846893310547,
-0.4647030234336853,
0.21351587772369385,
0.01043203566223383,
-0.29341572523117065,
0.7105841636657715,
-0.16059069335460663,
0.5519980788230896,
-0.038641586899757385,
-0.07982969284057617,
-0.29942095279693604,
-0.3424307703971863,
0.6249135136604309,
-0.47692859172821045,
0.24119606614112854,
-0.7357907891273499,
0.11403679102659225,
0.1433790773153305,
-0.03584655001759529,
0.17436008155345917,
-0.943370521068573,
0.08844170719385147,
0.040359970182180405,
-0.7037469744682312,
-0.41912510991096497,
0.36535829305648804,
0.5949226021766663,
-0.26730528473854065,
0.39585861563682556,
-0.0032082500401884317,
-0.48176974058151245,
0.14274002611637115,
0.3792242109775543,
-0.28313449025154114,
-0.3011888563632965,
0.32792556285858154,
-0.2947220206260681,
0.07371357828378677,
-0.3370475172996521,
0.09370289742946625,
-0.4482267498970032,
-0.2504311203956604,
-0.1896006464958191,
-0.06983305513858795,
0.33387455344200134,
-0.6793193817138672,
-0.25172075629234314,
-0.2961140275001526,
0.09670198708772659,
-0.19957000017166138,
0.2468327134847641,
-0.1067461371421814,
-0.6330618858337402,
-0.2303982377052307,
0.08613552898168564,
0.5574866533279419,
-0.5799775719642639,
-0.27211257815361023,
0.2599427402019501,
0.27362060546875,
0.2070169597864151,
-0.2923869490623474,
0.4428907036781311,
0.09570163488388062,
-0.2565070390701294,
0.5771706700325012,
0.4657461941242218,
-0.2748470902442932,
0.380928099155426,
0.20369018614292145,
0.28191864490509033,
0.2752360701560974,
0.5306820273399353,
0.7681758999824524,
0.3235306441783905,
0.4026966392993927,
0.13530832529067993,
-0.6835779547691345,
0.8010411858558655,
0.24700863659381866,
0.23805870115756989,
-0.12948592007160187,
0.3255499601364136,
0.34704431891441345,
0.09903222322463989,
0.1898626983165741,
0.4491298496723175,
0.14454929530620575,
0.006545689422637224,
0.16747263073921204,
-0.060062069445848465,
-0.4806518852710724,
-0.12824854254722595,
0.4843529462814331,
0.17672742903232574,
-0.5798045992851257,
0.19881753623485565,
0.46072888374328613,
0.2252662628889084,
0.24815776944160461,
-0.12912121415138245,
-0.15433862805366516,
0.07093221694231033,
0.29498574137687683,
0.29725056886672974,
-0.3773447871208191,
-0.24507535994052887,
-0.4737316370010376,
0.15559200942516327,
0.4772558808326721,
-0.21830227971076965,
-0.3018110394477844,
-0.06422100961208344,
0.10468991845846176,
-0.12484052032232285,
-0.5674972534179688,
0.22959132492542267,
-0.565808892250061,
-0.42751944065093994,
0.3669110834598541,
-0.2208343744277954,
-0.11388382315635681,
0.19979844987392426,
-0.22359082102775574,
-0.3918067216873169,
-0.3593381941318512,
0.6249868869781494,
0.0851491317152977,
-0.20198459923267365,
0.412666380405426,
0.17096848785877228,
0.3715062141418457,
0.3921819031238556,
-0.04616469517350197,
0.2289116233587265,
-0.46122652292251587,
-0.5714395046234131,
-0.41601693630218506,
-0.23094455897808075,
-0.11381880939006805,
0.11694552004337311,
-0.019151804968714714,
-0.08825396746397018,
0.2618349492549896,
-0.3263539671897888,
0.05938640981912613,
0.01880774460732937,
0.2569006085395813,
-0.665677547454834,
0.2700751721858978,
0.5073946118354797,
-0.6332181096076965,
0.848469078540802,
0.055462706834077835,
0.33952590823173523,
0.07590728253126144,
0.5177198648452759,
-0.053071532398462296,
-0.03628949075937271,
-0.5327606797218323,
0.5213554501533508,
-0.6962370872497559,
-0.20333608984947205,
0.5785073041915894,
0.5518836975097656,
0.01955939084291458,
-0.34229299426078796,
0.41240036487579346,
-0.31099817156791687,
0.15984253585338593,
-0.8039798736572266,
-0.42926621437072754,
-0.5257142782211304,
-0.13867869973182678,
-0.6485297083854675,
0.2784442603588104,
-0.1859525591135025,
-0.44558560848236084,
-0.3515603840351105,
0.43883660435676575,
0.42023009061813354,
-0.2501298785209656,
0.5519522428512573,
0.24172016978263855,
0.22284482419490814,
-0.2789267897605896,
0.21779197454452515,
-0.13069500029087067,
-0.37122681736946106,
-0.39716637134552,
0.20340974628925323,
-0.16240224242210388,
0.11583958566188812,
-0.2125881463289261,
-0.08833497762680054,
-0.21221007406711578,
-0.15752336382865906,
0.22625449299812317,
-0.043166834861040115,
-0.18690671026706696,
-0.4787347614765167,
-1.0140169858932495,
0.15372969210147858,
-0.24182333052158356,
-0.414309024810791,
-0.33762261271476746,
0.17014022171497345,
0.35107895731925964,
-0.01495289709419012,
-0.26717934012413025,
-0.5823102593421936,
-0.000382376805646345,
-0.14668329060077667
] |
BACKGROUND: Back in 1987, the World Health Organization (WHO) concluded that the screening of international travellers was an ineffective way to prevent the spread of HIV. However, some countries still restrict the entrance and/or residency of foreigners with an HIV infection. HIV-related travel restrictions have serious implications for individual and public health, and violate internationally recognized human rights. In this study, we reviewed the current situation regarding HIV-related travel restrictions in the 53 countries of the WHO European Region. METHODS: We retrieved the country-specific information chiefly from the Global Database on HIV Related Travel Restrictions at hivtravel.org. We simplified and standardized the database information to enable us to create an overview and compare countries. Where data was outdated, unclear or contradictory, we contacted WHO HIV focal points in the countries or appropriate non-governmental organizations. The United States Bureau of Consular Affairs website was also used to confirm and complement these data. RESULTS: Our review revealed that there are no entry restrictions for people living with HIV in 51 countries in the WHO European Region. In 11 countries, foreigners living with HIV applying for long-term stays will not be granted a visa. These countries are: Andorra, Armenia, Cyprus (denies access for non-European Union citizens), Hungary, Kazakhstan, Moldova, the Russian Federation, Tajikistan, Turkmenistan, Ukraine and Uzbekistan. In Uzbekistan, an HIV-positive foreigner cannot even enter the country, and in Georgia, we were not able to determine whether there were any HIV-related travel restrictions due to a lack of information. CONCLUSIONS: In 32% of the countries in the European Region, either there are some kind of HIV-related travel restrictions or we were unable to determine if such restrictions are in force. Most of these countries defend restrictions as being justified by public health concerns. However, there is no evidence that denying HIV-positive foreigners access to a country is effective in protecting public health. Governments should revise legislation on HIV-related travel restrictions. In the meantime, a joint effort is needed to draw attention to the continuing discrimination and stigmatization of people living with HIV that takes place in those European Region countries where such laws and policies are still in force. | [
-0.00777425616979599,
0.014219896867871284,
-0.006528693251311779,
0.015680313110351562,
0.008579516783356667,
0.014000325463712215,
0.008787086233496666,
0.023429840803146362,
-0.015515930950641632,
-0.008653026074171066,
-0.0013447944074869156,
0.015250688418745995,
-0.003353211097419262,
0.014999138191342354,
-0.020211979746818542,
-0.02074630744755268,
-0.009410280734300613,
0.02179466187953949,
0.010833445936441422,
0.0032471762970089912,
-0.0028341978322714567,
0.01375315710902214,
0.009528863243758678,
-0.0337221622467041,
0.00002916809171438217,
0.017487619072198868,
-0.015092482790350914,
-0.011639973148703575,
0.0030115479603409767,
-0.004165127407759428,
0.008941257372498512,
0.009189502336084843,
0.005537494085729122,
-0.019639113917946815,
0.0038451605942100286,
-0.01156571414321661,
0.0027353353798389435,
0.01658603921532631,
-0.009916896000504494,
-0.004133688285946846,
0.0011187470518052578,
-0.007308965548872948,
0.003058000933378935,
0.014357095584273338,
-0.004530920647084713,
-0.008412763476371765,
-0.005000247620046139,
-0.02642347849905491,
-0.00788845494389534,
0.01132267527282238,
0.00480529572814703,
-0.011895136907696724,
-0.009082245640456676,
-0.0021131709218025208,
-0.006253426428884268,
0.004958580248057842,
0.01770465448498726,
0.008286637254059315,
-0.011344049125909805,
0.01921459473669529,
0.006921799387782812,
-0.009575443342328072,
0.035464778542518616,
0.015584410168230534,
0.019189378246665,
-0.06733247637748718,
-0.016612783074378967,
0.008975446224212646,
0.002179340925067663,
0.0066404081881046295,
0.0008314661681652069,
0.007087382487952709,
-0.0044364891946315765,
-0.0005437154322862625,
-0.018487635999917984,
-0.0018547704676166177,
0.0226762518286705,
0.03829416260123253,
0.004917641635984182,
0.01274971291422844,
-0.02938930131494999,
0.01959051564335823,
-0.02009253203868866,
0.009696530178189278,
0.016249600797891617,
-0.00957463774830103,
-0.014960940927267075,
-0.00846962258219719,
0.017440855503082275,
0.014784367755055428,
0.008849861100316048,
-0.005337377078831196,
-0.02676059864461422,
-0.02243998274207115,
-0.019074980169534683,
-0.016354769468307495,
-0.012983573600649834,
-0.010201599448919296,
0.007166787050664425,
0.00824270211160183,
0.007423785515129566,
0.02233487367630005,
0.01368209719657898,
-0.00033222977072000504,
0.007783914916217327,
0.012807304039597511,
-0.008482043631374836,
0.01410144567489624,
-0.011464675888419151,
0.007543905172497034,
-0.00183189008384943,
0.00631454773247242,
0.014391887933015823,
0.016456810757517815,
-0.002636686898767948,
0.01573909819126129,
0.009746654890477657,
0.022396139800548553,
0.007947701960802078,
0.023501839488744736,
-0.0043339356780052185,
-0.0017141257412731647,
0.007976096123456955,
-0.0017655440606176853,
-0.0038360136095434427,
0.008839993737637997,
0.005664851516485214,
0.011940259486436844,
-0.021722640842199326,
0.006027404218912125,
-0.007014429662376642,
-0.004602835513651371,
0.009596122428774834,
-0.021073924377560616,
0.0003825775347650051,
-0.000500622671097517,
-0.020867301151156425,
0.01474062167108059,
0.004320582840591669,
-0.00043317442759871483,
-0.013494781218469143,
0.011081064119935036,
-0.005212787073105574,
0.008490570820868015,
0.02968946285545826,
0.0040398999117314816,
-0.0358453243970871,
0.007587713189423084,
0.012597573921084404,
-0.0050862450152635574,
-0.0010446120286360383,
-0.001171251991763711,
0.011887999251484871,
-0.016664555296301842,
-0.02709294483065605,
0.014263231307268143,
-0.016659028828144073,
-0.014856322668492794,
-0.009679961018264294,
-0.004747113212943077,
-0.0008367982227355242,
0.013242091983556747,
-0.002265314105898142,
0.00715348357334733,
0.016428589820861816,
-0.0009458678541705012,
-0.011400241404771805,
0.003198726335540414,
0.00466375844553113,
0.0024975815322250128,
-0.006063004955649376,
-0.0030702250078320503,
0.007258597761392593,
0.007395161781460047,
-0.00642772950232029,
-0.00706353597342968,
0.01386612094938755,
0.009997174143791199,
-0.0054247756488621235,
0.06683331727981567,
0.01101458165794611,
0.009793678298592567,
0.013683127239346504,
0.015005765482783318,
0.007458066567778587,
0.006480273324996233,
-0.009486474096775055,
-0.009234141558408737,
0.011959701776504517,
0.0017333882860839367,
0.0003071448300033808,
-0.00899588968604803,
-0.005966263357549906,
-0.002594271907582879,
-0.002844382543116808,
0.004476491827517748,
0.03579925745725632,
0.014294911175966263,
-0.007519442122429609,
0.009556394070386887,
0.025550294667482376,
0.024149833247065544,
0.023343082517385483,
-0.011039704084396362,
-0.009957436472177505,
0.014955836348235607,
0.0010315640829503536,
-0.0065141418017446995,
0.006437679752707481,
-0.020488865673542023,
0.009414618834853172,
-0.014113638550043106,
-0.0011960937408730388,
-0.007751707453280687,
-0.03326649218797684,
-0.0015526297502219677,
0.015336617827415466,
-0.014538240619003773,
0.02055959776043892,
-0.016328975558280945,
-0.012188991531729698,
0.02652140147984028,
0.011472063139081001,
-0.0024065510369837284,
0.024621859192848206,
0.009161938913166523,
0.0033492683432996273,
0.01240584533661604,
0.0002333610027562827,
0.008097068406641483,
-0.012625542469322681,
0.0050810943357646465,
-0.006854709703475237,
0.02426520362496376,
0.005381499417126179,
0.005894822999835014,
0.010232314467430115,
-0.005479661747813225,
0.021713241934776306,
-0.0165396798402071,
0.0068176561035215855,
-0.033717114478349686,
0.013871736824512482,
0.007818312384188175,
0.010505898855626583,
-0.007215694058686495,
0.011415626853704453,
0.004895450547337532,
-0.03729207068681717,
-0.0041922470554709435,
0.004924959037452936,
0.01165285985916853,
0.020250748842954636,
0.01611264981329441,
0.0125571358948946,
-0.0013215051731094718,
-0.0029240851290524006,
-0.021845394745469093,
0.02466306835412979,
-0.022308632731437683,
0.01178368367254734,
0.0046572210267186165,
-0.010311910882592201,
-0.03385100141167641,
0.010065782815217972,
0.03278689458966255,
-0.015569424256682396,
0.009841883555054665,
-0.019453397020697594,
0.018857819959521294,
0.0007870937697589397,
-0.005756954196840525,
-0.003785656299442053,
-0.08173643052577972,
-0.011409509927034378,
0.012398043647408485,
-0.018675606697797775,
0.009648213163018227,
-0.004133229143917561,
-0.0021781425457447767,
0.012161707505583763,
-0.015136840753257275,
0.013138450682163239,
0.03305993229150772,
0.03605090081691742,
-0.01007762085646391,
-0.018011830747127533,
0.0015344725688919425,
-0.0003556606243364513,
0.0037966712843626738,
0.016815777868032455,
-0.014564555138349533,
0.005806248635053635,
-0.03157573938369751,
-0.0064130485989153385,
0.04266270995140076,
-0.00817468948662281,
0.016300838440656662,
0.00069022411480546,
0.010125115513801575,
-0.009792590513825417,
-0.02497750148177147,
-0.0015846333699300885,
0.013504656963050365,
-0.010354219004511833,
0.024558786302804947,
-0.02270837128162384,
0.008774087764322758,
-0.028683830052614212,
-0.0018487724009901285,
-0.019323352724313736,
-0.01368675846606493,
0.007430467754602432,
0.013025883585214615,
0.016567818820476532,
0.013255197554826736,
0.013008913025259972,
0.006954621057957411,
-0.009461075067520142,
0.003972220700234175,
0.03792808949947357,
0.007537186145782471,
0.004356581252068281,
0.027569912374019623,
-0.023025348782539368,
0.010464510880410671,
0.012924397364258766,
-0.006066510919481516,
-0.003209563670679927,
-0.015438438393175602,
0.003142851870507002,
-0.009719663299620152,
-0.006131584756076336,
0.019285619258880615,
-0.005478174891322851,
0.022082727402448654,
0.013148234225809574,
-0.00039171427488327026,
-0.010834529995918274,
0.0007642707787454128,
0.0048239273019135,
-0.013033445924520493,
-0.0014512216439470649,
-0.016421003267169,
-0.01808711141347885,
0.021319855004549026,
-0.012469056062400341,
0.019537869840860367,
-0.001985597424209118,
-0.016640890389680862,
0.011426851153373718,
0.03062235563993454,
0.015139713883399963,
0.0014321166090667248,
0.014942016452550888,
-0.0033812164328992367,
-0.002840997651219368,
0.008924390189349651,
0.013749220408499241,
0.012049417942762375,
0.008533742278814316,
0.012713395059108734,
-0.01506378035992384,
0.02379857376217842,
0.008528976701200008,
0.0016346150077879429,
0.008346457034349442,
-0.0028869351372122765,
-0.005460640415549278,
0.0228283628821373,
0.0160197950899601,
-0.013598855584859848,
0.008815073408186436,
-0.016647975891828537,
-0.0016738882986828685,
-0.019530754536390305,
-0.013906816020607948,
0.011215130798518658,
0.011471239849925041,
0.012079042382538319,
-0.015132770873606205,
-0.010294469073414803,
-0.009428754448890686,
-0.004289558622986078,
0.005458740051835775,
-0.003501417115330696,
0.00456621078774333,
0.010118940845131874,
0.029920371249318123,
0.000788011122494936,
0.015668654814362526,
0.07269972562789917,
0.0002189241349697113,
0.005226469598710537,
-0.005124512128531933,
0.007413025945425034,
-0.014956490136682987,
-0.0014782203361392021,
-0.01836252212524414,
0.009820736013352871,
-0.011075714603066444,
0.01250370591878891,
-0.003417676081880927,
-0.021262627094984055,
-0.029034635052084923,
0.019006924703717232,
0.012831252999603748,
0.008763810619711876,
0.021550511941313744,
-0.0010624234564602375,
0.0032557412050664425,
-0.00046220130752772093,
0.021615568548440933,
-0.0025228983722627163,
0.0073948390781879425,
-0.004900657571852207,
-0.010325548239052296,
-0.028417129069566727,
-0.011343581601977348,
-0.005879619158804417,
-0.004931390285491943,
0.009757990017533302,
0.01173081248998642,
-0.004490670748054981,
-0.012161174789071083,
-0.0057002343237400055,
-0.0010290611535310745,
-0.012478059157729149,
0.0027344883419573307,
-0.00166931445710361,
-0.008618438616394997,
0.020663760602474213,
-0.012350847944617271,
0.00827409140765667,
0.007191034033894539,
-0.0033337962813675404,
0.025959838181734085,
-0.02117633819580078,
0.00018988864030689,
-0.004596952814608812,
0.013586049899458885,
-0.002977668074890971,
0.00981541071087122,
0.01371556892991066,
0.006869811099022627,
0.008717687800526619,
-0.000059888698160648346,
-0.012033579871058464,
-0.0009215662139467895,
0.024868084117770195,
0.011483509093523026,
-0.01754118502140045,
0.00024477322585880756,
0.026025846600532532,
-0.0014147511683404446,
0.01704419031739235,
-0.007030277047306299,
-0.005891842767596245,
0.002974485279992223,
0.003381160320714116,
-0.004263799637556076,
-0.009017039090394974,
-0.013342590071260929,
-0.0029787204694002867,
-0.0076248315162956715,
-0.052943747490644455,
0.007191370707005262,
-0.00579298660159111,
0.019751401618123055,
0.015154557302594185,
-0.03212432190775871,
0.015227602794766426,
-0.01128854975104332,
0.0313568040728569,
0.0072208489291369915,
0.017500298097729683,
0.00946955569088459,
-0.0046746451407670975,
-0.07472127676010132,
-0.01682869717478752,
0.00423493841663003,
-0.011317956261336803,
0.0224602110683918,
0.0014594527892768383,
-0.024471867829561234,
0.015649793669581413,
-0.009147314354777336,
-0.0096577238291502,
-0.010714101605117321,
-0.014567535370588303,
0.014569034799933434,
0.006602277979254723,
0.013206390663981438,
0.014683691784739494,
-0.008617673069238663,
-0.008569527417421341,
0.00009958050213754177,
-0.003544723615050316,
-0.009766106493771076,
-0.0037247021682560444,
-0.04291917756199837,
-0.009197063744068146,
0.007402405142784119,
-0.0811104029417038,
-0.014200997538864613,
-0.0012052655220031738,
-0.02992897480726242,
0.010880272835493088,
0.013928046450018883,
0.01066314522176981,
-0.014533093199133873,
-0.026044487953186035,
-0.013844859786331654,
-0.0018825354054570198,
0.006207476370036602,
0.01610873080790043,
-0.00797218456864357,
0.010649105533957481,
-0.010393591597676277,
-0.0039934138767421246,
0.029673557728528976,
0.00422989297658205,
0.003929419443011284,
-0.005699668079614639,
0.02794785238802433,
-0.0030944684986025095,
0.006132233887910843,
-0.01231660321354866,
-0.013971871696412563,
-0.0003982745110988617,
0.007164372131228447,
0.01981796696782112,
0.00540443230420351,
-0.0038138823583722115,
0.02998989075422287,
0.00866991188377142,
-0.03077196702361107,
-0.003812684677541256,
-0.014134503901004791,
0.005283400882035494,
-0.0004819920286536217,
0.0041454206220805645,
-0.013796508312225342,
-0.00733046792447567,
-0.00990946963429451,
-0.012939493171870708,
0.0029323610942810774,
0.03588295727968216,
-0.017190860584378242,
0.010423613712191582,
-0.005536559037864208,
0.020753007382154465,
-0.00852916855365038,
0.001335812732577324,
-0.006038322113454342,
0.0010640588589012623,
-0.017032770439982414,
0.03872276842594147,
-0.00923500582575798,
-0.011133602820336819,
0.005182727240025997,
-0.00928535033017397,
0.0042871697805821896,
-0.003856783267110586,
0.007749452255666256,
0.02384282648563385,
0.07184401154518127,
-0.026920370757579803,
0.013500032015144825,
0.006207973696291447,
0.008828530088067055,
-0.003008345840498805,
-0.014120691455900669,
0.01660338044166565,
-0.026167603209614754,
-0.015260761603713036,
-0.017789512872695923,
-0.004551127087324858,
-0.01945451647043228,
0.009005928412079811,
-0.00219899695366621,
0.00910850428044796,
0.014764715917408466,
0.002733097644522786,
0.009837998077273369,
0.023893307894468307,
-0.0036545121110975742,
-0.0051155718974769115,
-0.026485063135623932,
-0.01831894740462303,
0.025470158085227013,
0.007575119845569134,
-0.0043301829136908054,
-0.004933416843414307,
-0.018787233158946037,
0.022008772939443588,
-0.009665334597229958,
-0.007808750495314598,
0.008997725322842598,
-0.013670874759554863,
-0.003723474685102701,
-0.027461454272270203,
-0.006991532631218433,
0.0013428737875074148,
0.006959824822843075,
0.005491601303219795,
0.015838056802749634,
-0.01786506548523903,
0.011913139373064041,
-0.019298192113637924,
0.014629874378442764,
-0.025278421118855476,
-0.005780369974672794,
0.012020468711853027,
0.012735606171190739,
0.02290373668074608,
-0.0028287870809435844,
-0.005176151171326637,
0.011605838313698769,
-0.0006915868725627661,
-0.006670714356005192,
0.0070327469147741795,
-0.003191541414707899,
0.011894408613443375,
0.03416184335947037,
-0.00190883525647223,
-0.005081256851553917,
-0.02043592557311058,
0.017948338761925697,
-0.014711299911141396,
0.014469675719738007,
0.01883501559495926,
0.003821299411356449,
-0.013599899597465992,
0.0033762117382138968,
0.01299840398132801,
-0.017551498487591743,
0.001917544985190034,
0.005176831036806107,
-0.023214854300022125,
0.026895998045802116,
0.017576072365045547,
0.0203452967107296,
-0.041902340948581696,
0.0022333022207021713,
0.0047708237543702126,
-0.0183570459485054,
-0.015222636982798576,
0.013749692589044571,
-0.002541347173973918,
-0.04714006185531616,
-0.015422850847244263,
-0.011773057281970978,
-0.014121726155281067,
-0.012654057703912258,
0.007086978759616613,
0.0066922567784786224,
0.003037499263882637,
-0.0018508172361180186,
0.0009960912866517901,
0.010948820039629936,
0.03506692126393318,
-0.02583232708275318,
0.009137298911809921,
-0.013416925445199013,
-0.01789999008178711,
0.003392960876226425,
-0.02581777609884739,
0.006692999042570591,
0.01916360668838024,
-0.00989837758243084,
-0.0188016127794981,
0.01241829339414835,
0.004994941409677267,
-0.0013373522087931633,
0.0064749689772725105,
-0.01179393008351326,
-0.004975444637238979,
0.026652660220861435,
-0.0018188138492405415,
-0.000988540705293417,
0.018643178045749664,
-0.0002556582912802696,
0.009206791408360004,
0.00896662287414074,
-0.009176487103104591,
-0.01530799176543951,
-0.015263067558407784,
-0.005726676434278488,
0.026074716821312904,
0.032987162470817566,
-0.0058981566689908504,
-0.004438925068825483,
-0.00962484534829855,
0.004497730638831854,
0.009859585203230381,
0.011666853912174702,
0.031025266274809837,
0.008436664938926697,
-0.003428560448810458,
0.018433673307299614,
0.032558418810367584,
-0.0016392911784350872,
0.01718274876475334,
0.002451504347845912,
-0.025241684168577194,
0.002217962173745036,
-0.013782988302409649,
0.008118735626339912,
-0.00883677788078785,
0.011093689128756523,
0.008596690371632576,
0.012186240404844284,
-0.00590934744104743,
0.009863901883363724,
0.010176269337534904,
0.012922288849949837,
0.0008129501948133111,
-0.0052510593086481094,
0.0007725320756435394,
-0.009548216126859188,
0.006887779571115971,
0.003640617011114955,
-0.05228089541196823,
-0.023078594356775284,
-0.01154395379126072,
-0.03004096820950508,
0.009351816028356552,
-0.02286941558122635,
0.024865232408046722,
-0.003043272066861391,
0.010905096307396889,
0.0009881408186629415,
-0.014975039288401604,
-0.0011012095492333174,
0.01998482272028923,
0.011148622259497643,
-0.034894704818725586,
-0.003173402277752757,
0.014917248860001564,
-0.019555218517780304,
0.002193960826843977,
0.006637603975832462,
-0.0020243958570063114,
-0.009211873635649681,
0.028433233499526978,
-0.007833550684154034,
0.0189007967710495,
0.00004230719059705734,
-0.009354859590530396,
0.0037314309738576412,
-0.0074530793353915215,
-0.01391797699034214,
0.004377131815999746,
0.013458502478897572,
-0.010839402675628662,
-0.004529761616140604,
-0.0012016207911074162,
-0.018498804420232773,
-0.003497782628983259,
-0.001071767881512642,
0.011302277445793152,
-0.008188184350728989,
-0.02322075515985489,
0.0007481123320758343,
0.015762288123369217,
-0.009555970318615437,
-0.003562536556273699
] | [
0.5455734729766846,
0.1099475845694542,
0.01661997102200985,
-0.03283187374472618,
0.38217246532440186,
0.0789584219455719,
0.4102095067501068,
-0.0641268789768219,
-0.4144044518470764,
-0.16458390653133392,
0.1272878646850586,
0.2013997882604599,
-0.17428451776504517,
0.19884225726127625,
-0.34192347526550293,
0.26886940002441406,
0.4479294717311859,
0.3514513373374939,
-0.11489523947238922,
-0.34440600872039795,
-0.26930806040763855,
-0.11632173508405685,
0.04617363214492798,
0.1439386010169983,
0.045871250331401825,
-0.05433938279747963,
0.34487318992614746,
-0.08684201538562775,
-0.476335346698761,
-0.2521612048149109,
0.017488528043031693,
0.2448173314332962,
0.00391286239027977,
0.07268562912940979,
0.041310954838991165,
-0.09705847501754761,
0.09272443503141403,
-0.046827878803014755,
0.3226510286331177,
-0.39772599935531616,
-0.15315139293670654,
0.11720424145460129,
-0.18492282927036285,
0.42018112540245056,
0.27622607350349426,
-0.6330981850624084,
-1.1792207956314087,
0.46531978249549866,
-0.15086349844932556,
-0.025494642555713654,
0.17530329525470734,
0.03990679979324341,
0.07025030255317688,
0.5629871487617493,
0.13106763362884521,
-0.06890058517456055,
-0.31876417994499207,
-0.34416627883911133,
0.14641574025154114,
-0.3813896179199219,
0.4699626863002777,
0.09779662638902664,
0.1538052260875702,
0.32432296872138977,
0.22992925345897675,
0.552825391292572,
0.3370264172554016,
0.17701506614685059,
0.15356509387493134,
-0.4736024737358093,
-0.023809343576431274,
-0.4400207996368408,
-0.15780925750732422,
0.003887898987159133,
-0.22236107289791107,
0.03706233575940132,
0.20221416652202606,
-0.3926919102668762,
0.3271371126174927,
-0.2066241353750229,
0.06516136229038239,
-0.05500934645533562,
0.17021971940994263,
-0.6151821613311768,
0.6336886286735535,
-0.08009114861488342,
-0.29005661606788635,
0.2095794975757599,
0.19671466946601868,
-0.2905880808830261,
-0.13420143723487854,
0.06043384596705437,
0.12675921618938446,
0.4404255449771881,
0.0027242510113865137,
0.15686433017253876,
0.05213030055165291,
-0.038502778857946396,
0.4382879137992859,
0.12693670392036438,
-0.2309536188840866,
-0.06947847455739975,
0.018388932570815086,
-0.12236049026250839,
-0.2188544124364853,
-0.5210557579994202,
0.14356139302253723,
0.1414608508348465,
-0.3445625901222229,
0.5814258456230164,
-0.3313573896884918,
0.20093366503715515,
0.020869877189397812,
-0.20926927030086517,
-0.22273652255535126,
0.3431803584098816,
-0.05514104291796684,
-0.6329001784324646,
-0.02626093104481697,
0.3567189574241638,
-0.33087682723999023,
0.4898405075073242,
-0.34024783968925476,
0.24309954047203064,
0.27320364117622375,
0.18376772105693817,
0.8453826904296875,
0.7220919132232666,
-0.5670443773269653,
0.3650381565093994,
0.10940062254667282,
0.8027988076210022,
-0.19438716769218445,
0.1117614284157753,
-0.40855932235717773,
-0.13306821882724762,
0.16661080718040466,
0.5774884819984436,
0.058325834572315216,
-0.14863307774066925,
-0.3216101825237274,
-0.5559307932853699,
-0.39298364520072937,
0.27603504061698914,
-0.08325967192649841,
-0.715183436870575,
0.22250352799892426,
-0.2749394178390503,
0.10884642601013184,
-0.36492446064949036,
0.06863871961832047,
-0.20277971029281616,
-0.2797492444515228,
-0.2626733183860779,
-0.07031232118606567,
0.2725846767425537,
0.14028392732143402,
-0.0625496432185173,
-0.3950439393520355,
-0.34242185950279236,
0.4136543869972229,
0.20630313456058502,
-0.4872327744960785,
0.0342378169298172,
0.38357672095298767,
-0.1390172392129898,
-0.32350867986679077,
0.275143563747406,
0.2588198184967041,
0.5984108448028564,
-0.4071434438228607,
-0.14011532068252563,
-0.3498515486717224,
-0.4100276529788971,
-0.3599053919315338,
0.4567125141620636,
0.44109421968460083,
0.14497262239456177,
0.14307409524917603,
0.28012892603874207,
-0.5131353139877319,
0.07170745730400085,
-0.08503798395395279,
-0.5093912482261658,
0.20385301113128662,
-0.017971258610486984,
0.31568390130996704,
0.23807959258556366,
-0.23994053900241852,
-0.31199851632118225,
-0.32328304648399353,
-0.5311729311943054,
0.4602631628513336,
-0.797577440738678,
1.2583485841751099,
-0.41340550780296326,
-0.03277161344885826,
1.477718710899353,
-0.20559272170066833,
0.1913798600435257,
0.18343913555145264,
0.4275902509689331,
0.8147221207618713,
0.13352467119693756,
-0.8273587822914124,
0.3570881187915802,
-0.0005010637105442584,
-0.024072818458080292,
-0.22871477901935577,
0.10837507247924805,
0.5942465662956238,
-0.1661098450422287,
-0.320944607257843,
-0.17888060212135315,
-0.08428193628787994,
0.29234471917152405,
-0.14969761669635773,
0.2553153336048126,
0.22099553048610687,
-0.010158858262002468,
0.515988826751709,
-0.4760468900203705,
0.30178380012512207,
0.3649986684322357,
0.11228194087743759,
0.29707151651382446,
0.35701343417167664,
0.3578053414821625,
0.5216586589813232,
-0.8834671974182129,
0.14290033280849457,
0.17588751018047333,
0.5413345098495483,
-0.656060516834259,
-0.6233697533607483,
0.14702410995960236,
0.012574764899909496,
-0.29990890622138977,
-0.07683957368135452,
0.35284942388534546,
0.30853506922721863,
0.13349740207195282,
-0.48780614137649536,
0.2091616988182068,
-0.06516202539205551,
-0.2626820504665375,
-0.5179027915000916,
0.15040694177150726,
-0.3017078936100006,
0.09666960686445236,
0.42600300908088684,
0.2093956619501114,
-0.11373152583837509,
-0.3955228328704834,
0.501487135887146,
0.2650141417980194,
-0.14099177718162537,
-0.05766753479838371,
0.6801857352256775,
-0.3597230315208435,
0.1417350023984909,
0.49857422709465027,
0.10177182406187057,
0.1988144814968109,
0.026474930346012115,
-0.11851368844509125,
-0.7964929938316345,
-0.5126177668571472,
0.5069476962089539,
0.8093449473381042,
0.36385929584503174,
0.3242431879043579,
-0.8757655024528503,
0.04916413128376007,
0.02164713852107525,
-0.18943654000759125,
0.03778401389718056,
0.9242376089096069,
-0.20693489909172058,
-0.1897822916507721,
-0.20711177587509155,
-0.015152018517255783,
0.6686821579933167,
-0.34435752034187317,
0.00833911169320345,
-0.5602537393569946,
0.09087119251489639,
-0.354729026556015,
-0.35902532935142517,
0.12743671238422394,
0.4189102053642273,
0.5608915090560913,
-0.4221172630786896,
-0.4325384795665741,
0.881677508354187,
0.5373145937919617,
-0.34996744990348816,
0.4727928638458252,
0.4565748870372772,
0.05410374701023102,
0.27326375246047974,
0.4212627708911896,
-0.14585445821285248,
-0.04911400005221367,
-0.10349155962467194,
0.05467410758137703,
-0.460864394903183,
-0.5657086372375488,
-6.116044044494629,
0.399697870016098,
-0.37195464968681335,
-0.09179510921239853,
-0.7270069122314453,
0.1491532027721405,
1.1080025434494019,
-0.0019970403518527746,
0.17852628231048584,
-0.12479030340909958,
0.1658623367547989,
0.45007646083831787,
0.04488411173224449,
0.46565356850624084,
0.1704614758491516,
0.564460813999176,
0.22980593144893646,
-0.07709050923585892,
-0.1303996443748474,
0.21007272601127625,
-0.018076777458190918,
-0.24234625697135925,
0.2972509562969208,
0.1911465972661972,
0.30191394686698914,
0.2604905068874359,
-0.8701818585395813,
0.595719039440155,
-0.1488332748413086,
-0.05801716446876526,
0.2931709587574005,
-0.39292585849761963,
-0.13940009474754333,
-0.3287789821624756,
-0.0008318802574649453,
0.07417632639408112,
0.42563319206237793,
-0.34166404604911804,
0.09751102328300476,
-0.48955681920051575,
-0.2224377542734146,
0.6565840244293213,
0.20842880010604858,
0.06316909193992615,
0.010788565501570702,
-0.2682589888572693,
0.06621871888637543,
-0.001392814563587308,
-0.19309836626052856,
0.7996861338615417,
-0.2789149880409241,
0.056248944252729416,
-0.12218648195266724,
0.6815549731254578,
-0.4314189553260803,
-0.3033142685890198,
-0.10935089737176895,
0.20767228305339813,
-0.4710329473018646,
0.4786403179168701,
0.08111338317394257,
-0.4123091995716095,
0.4189433753490448,
-0.7870569825172424,
-0.16534173488616943,
0.2994011640548706,
-0.957439661026001,
-0.7599459886550903,
-0.17691446840763092,
0.06402825564146042,
-0.45809367299079895,
-0.11662192642688751,
0.4001498818397522,
-0.6639034152030945,
-0.017714889720082283,
-0.2620053291320801,
-0.05887116119265556,
0.16766713559627533,
0.28812021017074585,
-0.2622978091239929,
0.224325031042099,
0.1135115846991539,
0.22799594700336456,
0.10215885192155838,
0.14621476829051971,
-0.24207738041877747,
-0.10172130167484283,
-0.05752234160900116,
-0.5938357710838318,
-0.0581965334713459,
0.9896844625473022,
-0.3922611474990845,
0.005899174604564905,
0.05006994679570198,
-0.03071858547627926,
0.900314211845398,
0.09474260360002518,
-0.4395875036716461,
0.3467120826244354,
-0.21735112369060516,
0.4382815957069397,
-0.07024148106575012,
-0.4305891692638397,
-1.1341363191604614,
-0.024927759543061256,
-0.12064439058303833,
-0.7140449285507202,
0.2289142906665802,
0.7780052423477173,
-0.5572072267532349,
-0.21827343106269836,
0.04072599485516548,
-0.29735371470451355,
-0.32707569003105164,
0.25544896721839905,
-0.2342499941587448,
0.1374775916337967,
-0.07715428620576859,
0.5121588110923767,
-0.20368289947509766,
0.10807986557483673,
0.4613867998123169,
0.28320032358169556,
0.3805442750453949,
0.20083409547805786,
-0.3745027482509613,
0.3645021617412567,
0.3337706923484802,
-0.39736518263816833,
0.19273369014263153,
-0.017819860950112343,
0.7194263339042664,
-0.0851311981678009,
-0.34528788924217224,
0.28259965777397156,
-0.10653018951416016,
-0.4719335734844208,
0.0015325737185776234,
0.26820847392082214,
0.009653078392148018,
-0.0832124650478363,
-0.38491594791412354,
0.04709311202168465,
-0.012166576460003853,
0.23835936188697815,
-0.01655205339193344,
-0.08481073379516602,
-0.03061472624540329,
-0.22023047506809235,
-0.02856118232011795,
0.00771431066095829,
-0.06403713673353195,
0.38737189769744873,
-0.010836408473551273,
-0.4194430410861969,
-0.12039205431938171,
0.8023836016654968,
0.3474622964859009,
-0.1263737678527832,
-0.4328511953353882,
0.391073077917099,
0.06625021994113922,
-0.7941009402275085,
0.015158116817474365,
0.4219091534614563,
-0.36381223797798157,
0.1891331523656845,
-0.681416928768158,
-0.1188393235206604,
0.36590006947517395,
0.06641558557748795,
-0.26844051480293274,
-0.22349750995635986,
-0.017538903281092644,
-0.061321184039115906,
0.023062627762556076,
-0.6555575728416443,
0.4686829745769501,
-0.26790204644203186,
-0.04207605868577957,
0.37852105498313904,
-0.4386254847049713,
-0.4596248269081116,
0.3097035884857178,
0.858200192451477,
0.40042945742607117,
0.00487102335318923,
-0.4229747951030731,
-0.34616619348526,
-0.5431726574897766,
0.13268621265888214,
0.11016474664211273,
0.5656031370162964,
-0.012865806929767132,
-0.10616980493068695,
-0.5324100852012634,
-0.16003674268722534,
0.15130506455898285,
-0.33378028869628906,
0.025973744690418243,
0.01677885465323925,
0.449481338262558,
-0.22955793142318726,
0.14162200689315796,
-0.16216130554676056,
-0.09848377853631973,
0.21395143866539001,
-0.1897960603237152,
-0.09947976469993591,
0.039190489798784256,
-0.4244818091392517,
-0.29298651218414307,
-0.19507624208927155,
0.650447428226471,
-0.8192633986473083,
0.387018084526062,
-0.11217387020587921,
-0.2113925814628601,
-0.5933752059936523,
0.30276617407798767,
0.2942422926425934,
0.08637655526399612,
-0.5261958241462708,
-0.10223039239645004,
-0.16562451422214508,
0.0693705826997757,
0.6095973253250122,
-0.8304744958877563,
-0.12329109758138657,
0.33448782563209534,
-0.7714951038360596,
0.031296662986278534,
0.3300418257713318,
-0.17750534415245056,
-0.9150379300117493,
0.18514075875282288,
-0.06408067792654037,
0.055371396243572235,
0.3397067189216614,
0.6407762169837952,
0.10824546217918396,
0.6356426477432251,
0.39341866970062256,
-0.7854931354522705,
0.06656531244516373,
0.47259679436683655,
-0.169683039188385,
-0.6797704100608826,
-0.4213586747646332,
0.2781449258327484,
-0.19163769483566284,
-0.036634769290685654,
-0.0187966451048851,
-0.4013119637966156,
0.2788965404033661,
0.24963036179542542,
-0.2798005938529968,
-0.06168298050761223,
0.2982772886753082,
0.3007097840309143,
-0.052198752760887146,
-0.5742543339729309,
-0.3458864688873291,
-0.3810649812221527,
0.15962854027748108,
-0.11447109282016754,
-0.13063691556453705,
-0.03407828509807587,
0.057674579322338104,
-0.7029471397399902,
-0.17986410856246948,
-0.10214729607105255,
0.595725417137146,
0.0018679009517654777,
-0.017219647765159607,
-0.11396147310733795,
-0.021736694499850273,
0.20785805583000183,
0.014595664106309414,
0.18385657668113708,
-0.6685259342193604,
-0.7357673048973083,
0.2976779341697693,
-0.27606865763664246,
0.4118316173553467,
-0.1667068898677826,
0.15990446507930756,
0.29190728068351746,
-0.2134571075439453,
-0.541292667388916,
-0.161919504404068,
-0.22722232341766357,
-0.8067569732666016,
0.42243096232414246,
0.046524856239557266,
0.08514968305826187,
0.10330752283334732,
0.5132641792297363,
0.4029266834259033,
-0.6963369846343994,
-0.5832764506340027,
0.45463860034942627,
0.23236602544784546,
-0.5320128202438354,
0.21632184088230133,
0.20677922666072845,
0.433523029088974,
-0.18726082146167755,
0.25376400351524353,
0.48548105359077454,
0.43515604734420776,
-0.10920073837041855,
0.12842893600463867,
0.5537397265434265,
-0.5097474455833435,
-0.12959249317646027,
-0.015475621446967125,
-0.4759707748889923,
0.26343104243278503,
-0.0915231853723526,
0.06796158105134964,
0.44449949264526367,
0.35695722699165344,
-0.12525855004787445,
-0.21039055287837982,
0.49622800946235657,
-0.15328283607959747,
0.3718164563179016,
-0.0877387523651123,
-0.009634780697524548,
0.5314173698425293,
0.7918095588684082,
0.2802320718765259,
-0.11560159176588058,
-0.14317214488983154,
0.39472684264183044,
0.29804253578186035,
-0.7870434522628784,
-0.2063557207584381,
0.16348659992218018,
0.43075862526893616,
0.41619637608528137,
-0.1677745282649994,
-0.41330042481422424,
-0.17860600352287292,
0.4175417125225067,
-0.030435927212238312,
-0.1193690225481987,
0.053846172988414764,
0.34240201115608215,
0.23454950749874115,
-0.13295099139213562,
-0.34056878089904785,
0.25117504596710205,
-0.235775426030159,
0.0424923337996006,
0.16537362337112427,
-0.3558538258075714,
-0.8067485094070435,
-0.04447254538536072,
0.26632657647132874,
-0.1058831587433815,
-0.17586785554885864,
0.1790589541196823,
0.06634582579135895,
0.32773441076278687,
0.6754156351089478,
-0.2827768325805664,
0.2918742895126343,
-0.29984137415885925,
-0.1993040293455124,
-0.29069796204566956,
-0.46888598799705505,
0.18599474430084229,
0.2153485268354416,
-0.929073691368103,
0.4435509443283081,
-0.08125314116477966,
-0.16515356302261353,
0.19105222821235657,
-0.10778991878032684,
-0.2986714839935303,
0.15013264119625092,
-0.5838027000427246,
-0.19600310921669006,
-0.23607340455055237,
-0.23058180510997772,
-0.0376010537147522,
0.06755397468805313,
-0.031184153631329536,
-0.2804276645183563,
-0.8916004300117493,
-0.08278191089630127,
0.0695982500910759,
-0.18803521990776062,
-0.15947778522968292,
-0.2808910608291626,
0.8156593441963196,
0.31397950649261475,
-0.21941986680030823,
-0.1778930425643921,
-0.08602403849363327,
-0.2160119265317917,
0.33579662442207336,
-0.11628415435552597,
0.5367755889892578,
-0.6786510944366455,
-0.18851003050804138,
-0.1782238483428955,
0.23540112376213074,
0.5692167282104492,
0.03929448500275612,
-0.190731942653656,
-0.019298085942864418,
0.23624862730503082,
0.4219368100166321,
0.3058563768863678,
-0.160315603017807,
-0.18273478746414185,
-0.22132685780525208,
-0.40944617986679077,
-0.6392631530761719,
-0.15274445712566376,
-0.0884663462638855,
0.026162808761000633,
-0.2411072999238968,
0.30994006991386414,
0.6111702919006348,
-0.25610771775245667,
0.7501183748245239,
-0.21672596037387848,
-0.36087360978126526,
-0.5317488312721252,
0.3097217381000519,
-0.3579046130180359,
0.42969173192977905,
0.27641385793685913,
0.2544390857219696,
0.4494384825229645,
-0.02406899631023407,
0.010622466914355755,
-0.09162487834692001,
0.40740975737571716,
0.5332266092300415,
0.2664532959461212,
0.28909358382225037,
-0.015931278467178345,
-0.09707268327474594,
-0.44189825654029846,
0.26799437403678894,
-0.35858872532844543,
-0.3072076737880707,
-0.015010200440883636,
-0.10143809765577316,
-0.030809974297881126,
-0.10047958046197891,
-0.015379269607365131,
-0.7267884612083435,
-0.1913023740053177,
-0.22417156398296356
] |
The rapid emergence and subsequent spread of the novel 2009 Influenza A/H1N1 virus (2009 H1N1) has prompted the World Health Organization to declare the first pandemic of the 21(st) century, highlighting the threat of influenza to public health and healthcare systems. Widespread resistance to both classes of influenza antivirals (adamantanes and neuraminidase inhibitors) occurs in both pandemic and seasonal viruses, rendering these drugs to be of marginal utility in the treatment modality. Worldwide, virtually all 2009 H1N1 and seasonal H3N2 strains are resistant to the adamantanes (rimantadine and amantadine), and the majority of seasonal H1N1 strains are resistant to oseltamivir, the most widely prescribed neuraminidase inhibitor (NAI). To address the need for more effective therapy, we evaluated the in vitro activity of a triple combination antiviral drug (TCAD) regimen composed of drugs with different mechanisms of action against drug-resistant seasonal and 2009 H1N1 influenza viruses. Amantadine, ribavirin, and oseltamivir, alone and in combination, were tested against amantadine- and oseltamivir-resistant influenza A viruses using an in vitro infection model in MDCK cells. Our data show that the triple combination was highly synergistic against drug-resistant viruses, and the synergy of the triple combination was significantly greater than the synergy of any double combination tested (P<0.05), including the combination of two NAIs. Surprisingly, amantadine and oseltamivir contributed to the antiviral activity of the TCAD regimen against amantadine- and oseltamivir-resistant viruses, respectively, at concentrations where they had no activity as single agents, and at concentrations that were clinically achievable. Our data demonstrate that the TCAD regimen composed of amantadine, ribavirin, and oseltamivir is highly synergistic against resistant viruses, including 2009 H1N1. The TCAD regimen overcomes baseline drug resistance to both classes of approved influenza antivirals, and thus may represent a highly active antiviral therapy for seasonal and pandemic influenza. | [
-0.027068618685007095,
0.010653414763510227,
-0.00594599824398756,
0.023071765899658203,
0.0018766317516565323,
0.004869330674409866,
0.009338367730379105,
0.032191842794418335,
-0.020571649074554443,
-0.03877916932106018,
0.007535851094871759,
0.014864150434732437,
0.0074063134379684925,
-0.011177940294146538,
0.0031641717068850994,
-0.022083906456828117,
-0.005925140343606472,
0.039347514510154724,
0.02329004555940628,
-0.0016558142378926277,
-0.002579004503786564,
0.02643508091568947,
0.011769600212574005,
0.04525970667600632,
0.037918560206890106,
0.022578559815883636,
-0.012335546314716339,
-0.022527307271957397,
-0.040255650877952576,
-0.023225601762533188,
0.0007877605967223644,
0.023349113762378693,
-0.004960660822689533,
0.014857128262519836,
-0.011003181338310242,
0.015065891668200493,
-0.002433838788419962,
0.014120890758931637,
-0.021561961621046066,
-0.002509311307221651,
0.031505879014730453,
-0.02088051661849022,
0.0027408816386014223,
-0.009547306224703789,
-0.012301884591579437,
0.03497106581926346,
-0.0050781723111867905,
0.01861048862338066,
-6.249174475669861e-7,
0.006747720763087273,
-0.014028830453753471,
-0.023349367082118988,
-0.015933731570839882,
0.008929207921028137,
-0.007913872599601746,
0.03693608194589615,
0.023071683943271637,
0.002257468644529581,
-0.028552504256367683,
0.03654087334871292,
0.015345659106969833,
0.019276678562164307,
-0.00334132369607687,
0.0038463720120489597,
0.0013082204386591911,
-0.06558676064014435,
0.012573419138789177,
0.0024073754902929068,
0.0050086285918951035,
0.01575215347111225,
0.005576269701123238,
0.011531541123986244,
-0.0341116301715374,
-0.048586972057819366,
-0.035771965980529785,
0.024871259927749634,
0.002421500626951456,
0.02977198176085949,
0.02136974409222603,
0.03901660069823265,
-0.0008745940867811441,
-0.01090224925428629,
0.016344409435987473,
0.02207803539931774,
-0.02958381175994873,
0.012818732298910618,
-0.03385130316019058,
0.006968339439481497,
-0.012855696491897106,
0.022949162870645523,
0.010423360392451286,
-0.008462034165859222,
-0.0650133490562439,
-0.012977570295333862,
0.0586540587246418,
-0.02786370925605297,
-0.012479137629270554,
0.030853983014822006,
0.008286342024803162,
-0.010573729872703552,
0.0016655076760798693,
0.026958435773849487,
0.005376667715609074,
0.021591059863567352,
0.006222177762538195,
0.010028798133134842,
-0.01415823120623827,
0.006567234173417091,
0.02465791441500187,
0.0031515564769506454,
-0.027301816269755363,
-0.020484164357185364,
0.024363186210393906,
0.02173089049756527,
-0.01253367681056261,
0.028242886066436768,
0.005215333309024572,
0.030235525220632553,
0.0032763350754976273,
-0.00946902297437191,
-0.002077384851872921,
-0.024295391514897346,
0.006840360816568136,
-0.012153634801506996,
-0.006484010256826878,
0.0028575845062732697,
-0.0031219027005136013,
-0.008623005822300911,
0.00029904861003160477,
0.014425297267735004,
-0.009681005030870438,
-0.009209010750055313,
-0.036989301443099976,
-0.012266947887837887,
0.000713402172550559,
0.012284991331398487,
-0.02137564681470394,
-0.0005653025582432747,
-0.02261200174689293,
0.0009773921919986606,
-0.017393115907907486,
0.013402104377746582,
-0.0055780489929020405,
0.02903769724071026,
-0.0042620874010026455,
0.023271789774298668,
-0.005045374855399132,
0.014227638952434063,
0.054824426770210266,
0.020418386906385422,
0.013310986571013927,
0.010742302983999252,
-0.016652455553412437,
-0.002491109538823366,
0.005401785485446453,
0.02475786954164505,
0.021448077633976936,
-0.02619880810379982,
-0.0365009531378746,
0.04467131942510605,
-0.005744021385908127,
0.00701249809935689,
-0.04167252406477928,
0.00925271026790142,
0.02419733814895153,
-0.014657553285360336,
0.016091104596853256,
-0.006444783881306648,
-0.02159160003066063,
0.0108420979231596,
-0.006351980846375227,
0.004345203284174204,
-0.00012191175483167171,
0.026442579925060272,
0.02824937179684639,
-0.009053580462932587,
0.010747958905994892,
0.01139657013118267,
0.003806152381002903,
0.06537789106369019,
0.007948269136250019,
-0.018742075189948082,
0.01669802889227867,
0.03744583949446678,
-0.008475062437355518,
-0.013347746804356575,
0.05068133771419525,
-0.0009185760281980038,
-0.02286212518811226,
0.005289242137223482,
-0.015349875204265118,
-0.014846399426460266,
0.0070730834268033504,
-0.03517227992415428,
0.001006296370178461,
0.0028519725892692804,
0.01295518595725298,
0.004734318237751722,
-0.013326317071914673,
0.004582622088491917,
0.013499103486537933,
0.009735001251101494,
0.048078782856464386,
0.02941112034022808,
-0.01420997641980648,
0.02287396788597107,
0.004497736692428589,
0.01216086745262146,
0.005206907633692026,
-0.005787196569144726,
0.030152693390846252,
-0.026713216677308083,
-0.00492987222969532,
-0.008942283689975739,
-0.012358337640762329,
-0.023237239569425583,
0.0069253090769052505,
0.022762481123209,
-0.020924657583236694,
-0.018349701538681984,
-0.0015506487106904387,
0.0037501822225749493,
-0.058896347880363464,
0.014314161613583565,
0.0006109449313953519,
0.0043399753049016,
0.01553830225020647,
0.01636216789484024,
0.00022758962586522102,
-0.003838042262941599,
-0.013457786291837692,
-0.0002442002296447754,
-0.01670672371983528,
-0.011839251965284348,
0.011932680383324623,
-0.0034262146800756454,
0.01603577844798565,
-0.01702502928674221,
-0.005526871420443058,
-0.01806839555501938,
0.002481960691511631,
0.005732951685786247,
0.01621401123702526,
-0.002683678176254034,
0.048452746123075485,
0.014295305125415325,
0.0139624560251832,
-0.021111251786351204,
-0.04281286150217056,
-0.006084744352847338,
0.00962613895535469,
-0.0263025164604187,
0.02771325409412384,
0.03581031784415245,
-0.009700202383100986,
-0.013951241970062256,
0.026885900646448135,
0.010688893496990204,
0.02772524580359459,
0.02721322327852249,
0.018917277455329895,
0.008225904777646065,
-0.015271978452801704,
0.0016244584694504738,
-0.00620869779959321,
0.021303702145814896,
0.01149427518248558,
0.007265531923621893,
0.01948036625981331,
-0.0009228070266544819,
0.011387142352759838,
-0.010414516553282738,
0.011790578253567219,
-0.08080769330263138,
-0.01109704002737999,
-0.006317634601145983,
-0.023026807233691216,
0.010426323860883713,
0.00063085719011724,
0.019158586859703064,
0.007639837451279163,
-0.022427434101700783,
0.04836892709136009,
0.005157945211976767,
0.022447943687438965,
-0.006980726961046457,
-0.017007598653435707,
-0.01803860440850258,
0.0029726591892540455,
0.008489384315907955,
0.015527192503213882,
-0.04074130952358246,
-0.017219310626387596,
-0.01068125106394291,
0.008949130773544312,
0.049687884747982025,
-0.03156542032957077,
-0.015424054116010666,
0.0023929330054670572,
0.01968611776828766,
0.002972178626805544,
0.005318386945873499,
0.0005182201275601983,
0.017253486439585686,
-0.0421285480260849,
-0.025020938366651535,
0.005157263483852148,
0.031900499016046524,
0.0005693769780918956,
0.022497698664665222,
-0.011227377690374851,
0.007587553933262825,
-0.01810789667069912,
-0.0017516158986836672,
0.02072472870349884,
-0.0008493443019688129,
0.007214937824755907,
0.013584500178694725,
0.002977699041366577,
0.00957451481372118,
0.04200240597128868,
0.026594335213303566,
0.012710056267678738,
-0.01947946287691593,
-0.016255278140306473,
0.03290431946516037,
0.010218814015388489,
0.0018688945565372705,
-0.014997205697000027,
0.030514013022184372,
-0.00010058470070362091,
-0.012191182002425194,
0.012449425645172596,
-0.031096994876861572,
0.05020510405302048,
0.018472637981176376,
-0.006048292852938175,
-0.05747203528881073,
0.014485090970993042,
0.010426372289657593,
-0.023714572191238403,
-0.012666231021285057,
0.018997937440872192,
-0.01541663147509098,
0.011179019697010517,
0.007876327261328697,
-0.017030736431479454,
0.017158599570393562,
0.0014337924076244235,
-0.01745647005736828,
-0.020798368379473686,
-0.011094940826296806,
0.00789466593414545,
-0.006859662011265755,
-0.0069088018499314785,
-0.01133829914033413,
-0.0007231994532048702,
-0.013236666098237038,
-0.033767201006412506,
0.016399912536144257,
-0.024074949324131012,
0.020556475967168808,
-0.029216278344392776,
-0.015136509202420712,
0.008404597640037537,
-0.03927420452237129,
0.017918338999152184,
-0.01090204156935215,
-0.021046774461865425,
-0.012822916731238365,
0.002379694953560829,
-0.019726648926734924,
0.008337508887052536,
-0.003940972965210676,
-0.019160021096467972,
0.0009482456371188164,
-0.00804720539599657,
-0.00490983109921217,
0.01555926725268364,
0.012445797212421894,
-0.025506626814603806,
-0.02596716769039631,
-0.008670156821608543,
0.014040762558579445,
0.013638263568282127,
0.00881727784872055,
0.001046016113832593,
0.016177868470549583,
0.00544734438881278,
0.015267209149897099,
-0.030775871127843857,
0.070505291223526,
-0.007894828915596008,
0.010857775807380676,
0.008729653432965279,
0.033060379326343536,
-0.019016724079847336,
0.02207997255027294,
0.005719074979424477,
-0.0004947928246110678,
-0.030542585998773575,
0.014564009383320808,
-0.044272731989622116,
-0.0002542263828217983,
-0.029903804883360863,
-0.010454345494508743,
-0.030991271138191223,
-0.0064102839678525925,
-0.009094806388020515,
0.035598453134298325,
-0.015703340992331505,
-0.001479392871260643,
0.014102412387728691,
0.0022091525606811047,
-0.024470150470733643,
0.03456581011414528,
-0.0017457162030041218,
0.005740159656852484,
-0.009390350431203842,
0.0047925603576004505,
0.002965226536616683,
0.0015610617119818926,
-0.012636948376893997,
-0.006152272690087557,
-0.023160550743341446,
-0.001379143912345171,
-0.018586162477731705,
-0.014870334416627884,
-0.008008448407053947,
0.01327827200293541,
-0.022433139383792877,
0.013828245922923088,
-0.014421033672988415,
-0.005765719339251518,
0.019984237849712372,
-0.005231881979852915,
0.030357392504811287,
-0.02609233558177948,
-0.008345765992999077,
-0.007527592126280069,
0.006547830067574978,
-0.007064224220812321,
0.007215120829641819,
0.00869784876704216,
0.006996980868279934,
0.006662565283477306,
-0.00932474248111248,
0.03880662843585014,
-0.007853064686059952,
-0.007327122148126364,
-0.030369114130735397,
0.003838501637801528,
-0.010074613615870476,
0.004236939363181591,
-0.01607111096382141,
0.009607415646314621,
-0.005274854600429535,
-0.016124971210956573,
0.012997047044336796,
-0.04012542963027954,
-0.027260910719633102,
-0.01563536562025547,
0.003578765084967017,
0.011978721246123314,
-0.01190260425209999,
-0.04684937372803688,
-0.0052160900086164474,
-0.05626950412988663,
0.002558645326644182,
-0.030826672911643982,
0.03283161297440529,
-0.0013386746868491173,
-0.007473762147128582,
0.03959761932492256,
-0.0039530606009066105,
0.0017887447029352188,
0.01607494428753853,
-0.03778696805238724,
-0.07412390410900116,
0.0009164139628410339,
0.004151303321123123,
-0.007246026769280434,
-0.01837017759680748,
0.0071502747014164925,
-0.026810159906744957,
0.007540662307292223,
-0.010352974757552147,
-0.003072427585721016,
0.02570289559662342,
0.015206672251224518,
0.06065453588962555,
0.023415904492139816,
0.02296188846230507,
0.020150871947407722,
-0.056853726506233215,
0.00626774225383997,
-0.0021315894555300474,
-0.011141104623675346,
0.004965269938111305,
-0.0005424185656011105,
-0.06484884023666382,
-0.013437885791063309,
-0.00041086599230766296,
-0.07909168303012848,
-0.0319238156080246,
0.037282489240169525,
-0.01616188883781433,
-0.01109166257083416,
0.008570559322834015,
0.040784358978271484,
-0.04070935770869255,
-0.033762454986572266,
-0.01846049539744854,
0.009918240830302238,
0.01228516548871994,
-0.014991668052971363,
-0.011730967089533806,
0.03218534216284752,
-0.009451882913708687,
0.035468459129333496,
0.03205929696559906,
0.022568779066205025,
-0.0093491580337286,
0.024116186425089836,
0.030679967254400253,
-0.007973230443894863,
-0.023247063159942627,
-0.009208262898027897,
-0.012964064255356789,
-0.002762643853202462,
0.007322409655898809,
0.017070619389414787,
-0.006624746602028608,
-0.006839903071522713,
-0.020686214789748192,
0.026117511093616486,
0.01770971715450287,
0.03292395919561386,
-0.009227100759744644,
0.024166923016309738,
-0.023147176951169968,
0.025681722909212112,
0.009022990241646767,
-0.01027814019471407,
0.04393669590353966,
-0.0032051075249910355,
0.0034216446802020073,
-0.01024056039750576,
0.03650912642478943,
0.018448494374752045,
-0.016286950558423996,
0.023700322955846786,
-0.003819422796368599,
-0.00783602986484766,
-0.02064664475619793,
0.003024417906999588,
0.01989627070724964,
-0.010488513857126236,
0.013319292105734348,
-0.0014552249340340495,
0.021469753235578537,
0.023049568757414818,
0.017997195944190025,
0.00004304829053580761,
0.003915841691195965,
0.002887025475502014,
0.0698435977101326,
-0.019783124327659607,
0.02774873748421669,
-0.03306325897574425,
-0.02058667317032814,
0.00463392399251461,
0.021346185356378555,
0.012916304171085358,
-0.009165124036371708,
-0.015913449227809906,
0.03046039491891861,
-0.021840065717697144,
-0.010472207330167294,
0.008961224928498268,
-0.03252970799803734,
0.019959697499871254,
0.02049667201936245,
-0.030655687674880028,
0.01039328146725893,
-0.005327838473021984,
-0.02647475153207779,
0.026878874748945236,
-0.024795524775981903,
-0.019451914355158806,
0.012314989231526852,
-0.024014223366975784,
-0.042103637009859085,
0.007947703823447227,
-0.021851498633623123,
0.02762412093579769,
0.0016877180896699429,
0.007403528317809105,
0.0078072091564536095,
-0.00874977745115757,
0.015841685235500336,
-0.019171815365552902,
0.03616192564368248,
0.02062511071562767,
0.01870086044073105,
-0.029359538108110428,
0.0179973766207695,
-0.025550855323672295,
-0.0026138226967304945,
0.008213282562792301,
0.0266491137444973,
-0.022871345281600952,
-0.009340367279946804,
0.024800565093755722,
0.008114907890558243,
0.016980793327093124,
-0.010153374634683132,
0.012391556054353714,
0.010649871081113815,
-0.01035250723361969,
0.01460091583430767,
0.023473549634218216,
0.004170323256403208,
0.03277669474482536,
-0.003328760154545307,
-0.018709255382418633,
0.01825510710477829,
-0.023028608411550522,
-0.00827980600297451,
-0.016519559547305107,
-0.009371481835842133,
-0.008187932893633842,
0.0010752356611192226,
-0.03257983922958374,
0.02386666089296341,
0.0023434674367308617,
-0.0022685620933771133,
0.007883386686444283,
0.006211457774043083,
0.02846040576696396,
0.013214459642767906,
0.04312613233923912,
0.04612242802977562,
0.00493357889354229,
0.032290004193782806,
0.0045949919149279594,
-0.013752801343798637,
-0.01974201761186123,
0.029171206057071686,
0.02371671050786972,
-0.027904406189918518,
-0.016120295971632004,
0.020740075036883354,
-0.018709717318415642,
-0.0055482531897723675,
0.012856509536504745,
0.014005005359649658,
0.007606121711432934,
0.014662684872746468,
-0.013304870575666428,
0.01733124814927578,
0.03596679866313934,
0.027098417282104492,
0.01272184681147337,
0.014988962560892105,
-0.021289553493261337,
-0.03745338320732117,
-0.019834179431200027,
0.01490800641477108,
-0.0018324339762330055,
0.01104695163667202,
0.010238380171358585,
0.03860805556178093,
0.015578960999846458,
-0.01698129251599312,
0.0257211122661829,
-0.0251690074801445,
0.012332992628216743,
0.017076313495635986,
-0.018138201907277107,
0.02386573702096939,
-0.01185130700469017,
-0.020611438900232315,
-0.0006701396778225899,
0.0049407267943024635,
-0.0149913989007473,
-0.012180572375655174,
-0.018923386931419373,
-0.0044815740548074245,
0.04562543332576752,
-0.02277926355600357,
0.007478542625904083,
-0.01069648191332817,
-0.022616157308220863,
-0.028369585052132607,
0.00003808573819696903,
0.02430097386240959,
-0.028661582618951797,
-0.0009778167586773634,
-0.0024205362424254417,
-0.0065267328172922134,
0.01417627278715372,
0.022041765972971916,
-0.023644614964723587,
0.00972515158355236,
-0.006041809916496277,
-0.034972742199897766,
0.011168582364916801,
0.0022116252221167088,
-0.020262256264686584,
0.014285116456449032,
-0.0006232699379324913,
-0.009225279092788696,
-0.010421404615044594,
0.0076462700963020325,
0.0045233522541821,
-0.006070582661777735,
0.004347942769527435,
0.012564703822135925,
-0.0043320017866790295,
0.021143388003110886,
-0.003039962612092495,
0.00680856266990304,
-0.017349854111671448,
-0.013825150206685066,
0.014371831901371479,
-0.0031281651463359594,
0.010825488716363907,
0.023993920534849167,
-0.002141667064279318,
-0.009315968491137028,
-0.017402630299329758,
0.014504228718578815,
-0.001471402239985764,
-0.0029815160669386387,
0.0034715523943305016,
-0.029423773288726807,
-0.020709607750177383,
-0.008157260715961456,
0.016667932271957397,
-0.0010448158718645573,
-0.02505536749958992,
-0.014104479923844337,
-0.005035049747675657,
-0.01714055985212326,
0.017486093565821648,
0.0039245812222361565,
-0.004473303444683552,
0.006068352144211531,
-0.01702386885881424,
-0.005245765671133995,
0.020368676632642746,
-0.009001018479466438,
0.026786813512444496,
0.03025231696665287,
0.012513312511146069,
-0.03148842602968216,
-0.03101276233792305,
-0.012195874005556107,
0.007350328844040632,
-0.001281485427170992,
-0.021421829238533974,
-0.036060161888599396,
-0.021166745573282242,
0.020316515117883682,
0.00691405450925231,
0.03113456815481186,
0.015248967334628105
] | [
-0.14125102758407593,
0.010380269028246403,
-0.2910631000995636,
-0.33285999298095703,
-0.3959982395172119,
-0.09151233732700348,
0.47736606001853943,
0.3629654347896576,
-0.2597541809082031,
-0.39051923155784607,
-0.015898266807198524,
-0.07877267897129059,
-0.5590137839317322,
0.7008923292160034,
0.19877074658870697,
0.7370619177818298,
0.45386046171188354,
0.2213945835828781,
-0.12152046710252762,
0.023954421281814575,
-0.5047599077224731,
-0.625281572341919,
-0.03713880106806755,
-0.03640614449977875,
-0.22787410020828247,
-0.4110376238822937,
0.5147520899772644,
-0.21728786826133728,
0.45691850781440735,
0.057052262127399445,
0.21652109920978546,
0.6406848430633545,
0.10981597751379013,
-0.10616318881511688,
-0.04123368114233017,
0.02217664197087288,
-0.2312493622303009,
0.05517057329416275,
-0.15011164546012878,
-0.3018184304237366,
-0.43535134196281433,
-0.48787859082221985,
0.24466001987457275,
0.3840734362602234,
-0.0014782014768570662,
-0.2319309413433075,
-0.8299785852432251,
0.6308360695838928,
-0.11609239131212234,
0.2502484619617462,
0.2849547863006592,
-0.06375916302204132,
-0.23454159498214722,
0.020897606387734413,
0.15794791281223297,
0.3317100703716278,
-0.7563715577125549,
0.0777692049741745,
-0.055324479937553406,
-0.2582513689994812,
0.15877965092658997,
-0.38253191113471985,
-0.13768894970417023,
0.1427706778049469,
-0.571990430355072,
0.7306516766548157,
0.26722079515457153,
0.6208003759384155,
-0.5126462578773499,
-0.8211755156517029,
-0.2514801621437073,
-0.411050021648407,
-0.6272393465042114,
0.24115552008152008,
0.07486586272716522,
-0.3781321942806244,
-0.1852882355451584,
-0.47950148582458496,
0.16610375046730042,
0.4465758204460144,
0.11870656162500381,
0.35311511158943176,
0.21983268857002258,
-0.34721511602401733,
0.4984249770641327,
0.2397741973400116,
0.5072777271270752,
1.0314873456954956,
-0.217755526304245,
-0.03353658318519592,
0.5389441251754761,
0.3109693229198456,
0.9699910283088684,
-0.16447579860687256,
-0.34079116582870483,
0.2890542447566986,
0.11440354585647583,
0.12365057319402695,
0.25101733207702637,
-0.3923528492450714,
-0.2635403275489807,
-0.1303676962852478,
-0.34535419940948486,
-0.32713890075683594,
-0.28243181109428406,
0.09670920670032501,
-0.1262025088071823,
-0.6874301433563232,
-0.16061025857925415,
-0.0772058367729187,
-0.38464590907096863,
0.3275895416736603,
-0.26964327692985535,
-0.36652734875679016,
-0.4882945716381073,
0.536429762840271,
0.2251979559659958,
-0.8365981578826904,
0.24426385760307312,
-0.2795868217945099,
0.1097700223326683,
0.7994398474693298,
-0.08460171520709991,
0.32905492186546326,
-0.08938860893249512,
0.10522225499153137,
0.37250030040740967,
0.07976896315813065,
0.03268405422568321,
0.47380736470222473,
0.06204770505428314,
0.6567395329475403,
-0.3786563277244568,
-0.22621768712997437,
0.45145365595817566,
-0.21218550205230713,
-0.19683803617954254,
0.16724836826324463,
0.376516193151474,
-0.1470499485731125,
-0.6034736633300781,
-0.38448020815849304,
-0.4767947494983673,
0.39745497703552246,
0.07336249202489853,
0.09383320063352585,
-0.17426280677318573,
0.013879799284040928,
-0.22714924812316895,
-0.5835152268409729,
0.2623228132724762,
-0.41281232237815857,
-0.35593941807746887,
0.5265898108482361,
0.21053487062454224,
0.3009629547595978,
-0.09467019140720367,
-0.18881623446941376,
0.3086126744747162,
0.20580853521823883,
0.6553265452384949,
0.26279714703559875,
-0.3406004011631012,
-0.06455915421247482,
0.4200463891029358,
0.1611301749944687,
-0.2729720175266266,
0.7503486275672913,
0.12688562273979187,
-0.2878338694572449,
-0.4521249532699585,
0.027404800057411194,
0.15121273696422577,
-0.7152600288391113,
0.28261953592300415,
0.05249788239598274,
0.0302647203207016,
-0.035764046013355255,
0.4151301980018616,
0.40582722425460815,
-0.4609319865703583,
-0.10484793782234192,
0.23748059570789337,
-0.32150065898895264,
0.14072458446025848,
0.13547314703464508,
0.3375740051269531,
0.05689701810479164,
0.4977485239505768,
0.046145420521497726,
-0.671959638595581,
0.02546335570514202,
0.5610987544059753,
-0.3716902434825897,
1.1543716192245483,
0.01721387356519699,
-0.4673335552215576,
1.424039363861084,
0.44809019565582275,
0.10126467794179916,
-0.09276395291090012,
0.18828585743904114,
0.5124219059944153,
-0.18326885998249054,
-0.6526020169258118,
0.08388156443834305,
0.06988228112459183,
-0.35285913944244385,
-0.07227903604507446,
0.013645281083881855,
0.5832013487815857,
-0.46996304392814636,
-0.02429681457579136,
-0.08038866519927979,
0.2797004282474518,
0.29067137837409973,
-0.1260351985692978,
-0.031658172607421875,
0.08141907304525375,
-0.2099461704492569,
0.01715993508696556,
-0.8137292265892029,
-0.03785308822989464,
0.5002930164337158,
0.05825023725628853,
0.5512872338294983,
0.42077919840812683,
-0.4256473481655121,
0.666387140750885,
-0.3033359944820404,
0.07894841581583023,
-0.10448142886161804,
0.6924332976341248,
-0.7212536931037903,
0.0314762219786644,
0.05043502524495125,
0.1644190400838852,
0.06906350702047348,
0.04904428869485855,
-0.301639586687088,
0.7449516654014587,
0.20888358354568481,
-0.32755333185195923,
0.6119919419288635,
-0.06576848030090332,
0.003307450795546174,
-0.06658174097537994,
-0.017299607396125793,
-0.7902881503105164,
-0.263504296541214,
0.3042537271976471,
0.40638241171836853,
0.23527482151985168,
-0.1251128762960434,
-0.10112731158733368,
0.05518413707613945,
-0.00012690597213804722,
-0.1722533255815506,
0.32477569580078125,
-0.13349594175815582,
-0.3617481589317322,
0.17969131469726562,
0.44633424282073975,
0.6520313620567322,
0.032114312052726746,
-0.7484118342399597,
-0.5445958375930786,
-0.46544089913368225,
0.18226276338100433,
0.5389967560768127,
0.8593663573265076,
-0.36213570833206177,
-0.7953945398330688,
0.06625453382730484,
0.2756684124469757,
-0.5892283320426941,
-0.14518693089485168,
1.0449410676956177,
-0.8449183106422424,
0.011447682045400143,
-0.06302285939455032,
0.38705146312713623,
1.0711520910263062,
-0.9217798709869385,
-0.48794376850128174,
-0.41917383670806885,
0.2400321215391159,
-0.5513871908187866,
-0.5332055687904358,
-0.15102599561214447,
-0.06413992494344711,
0.05256056785583496,
-0.3818667531013489,
0.020773962140083313,
-0.26966771483421326,
-0.22864046692848206,
0.022412870079278946,
0.35231268405914307,
0.9016531109809875,
0.09888501465320587,
-0.2592681348323822,
0.022867664694786072,
-0.10320758819580078,
-0.08879107236862183,
-0.1626182496547699,
0.07597669959068298,
-0.16947829723358154,
-0.01578766480088234,
-5.968637943267822,
-0.10125289857387543,
0.033607352524995804,
-0.2164234220981598,
-0.016819283366203308,
0.3784656822681427,
1.080257534980774,
-0.14905208349227905,
0.12896372377872467,
0.008001134730875492,
0.8797563314437866,
0.3740539252758026,
0.027040215209126472,
-0.1999431699514389,
-0.3252526521682739,
0.07264897227287292,
0.26067933440208435,
-0.40720832347869873,
0.5506200194358826,
0.219890296459198,
0.19008798897266388,
0.11312435567378998,
-0.16177186369895935,
0.2925369441509247,
0.18829801678657532,
0.2392943948507309,
-1.131842851638794,
0.19665177166461945,
-0.34445446729660034,
0.12674306333065033,
0.3839835226535797,
-0.45636889338493347,
0.0653667077422142,
-0.1834072768688202,
-0.3562282621860504,
-0.1217956393957138,
-0.007367085199803114,
-0.5594189763069153,
-0.4694959819316864,
-0.5304021239280701,
0.008404716849327087,
0.006023377645760775,
-0.07792939245700836,
-0.06642765551805496,
0.17507793009281158,
0.12721027433872223,
0.3147644102573395,
0.2325000911951065,
-0.06773454695940018,
0.5024601221084595,
0.08101797103881836,
-0.06365107744932175,
-0.08924300968647003,
0.5133411884307861,
0.3422037959098816,
0.23911146819591522,
-0.4045032560825348,
0.3170240521430969,
-0.1810990273952484,
0.10533419996500015,
-0.038724422454833984,
-0.039683111011981964,
-0.2422507256269455,
-0.04935603588819504,
0.12507759034633636,
0.008646095171570778,
-0.248334139585495,
-0.5149876475334167,
0.5081314444541931,
-0.18378087878227234,
-0.43798643350601196,
-0.02353920042514801,
0.43806952238082886,
-0.7953259348869324,
0.3067970275878906,
-0.6516247391700745,
-0.1631849855184555,
-0.2642993927001953,
-0.04718907177448273,
-0.3423672318458557,
-0.6638363003730774,
-0.507311999797821,
-0.1565530002117157,
-0.28601139783859253,
0.3563329875469208,
-0.46577009558677673,
0.10651500523090363,
0.01895538717508316,
0.04646623134613037,
-0.0396709218621254,
0.43360358476638794,
-0.2518531084060669,
0.23076607286930084,
0.16276060044765472,
0.23713193833827972,
0.8219177722930908,
0.3812059462070465,
0.6768959760665894,
0.33248016238212585,
0.37010452151298523,
0.5804530382156372,
-0.17458005249500275,
-0.17030654847621918,
-0.8404543399810791,
-0.201673686504364,
0.22064928710460663,
-0.015501206740736961,
-0.03920671343803406,
0.9518919587135315,
-0.5931469798088074,
0.052107907831668854,
0.09281136095523834,
-0.08457735925912857,
-0.3177098035812378,
0.6722826957702637,
-0.1810804307460785,
0.28099697828292847,
0.45279818773269653,
0.5638567209243774,
-0.10394042730331421,
0.5071233510971069,
0.20567665994167328,
-0.9068964123725891,
0.08925578743219376,
0.20558570325374603,
0.0756400004029274,
0.06112808361649513,
0.20926710963249207,
-0.22935958206653595,
-0.33119580149650574,
0.08716654032468796,
0.35247841477394104,
-0.42174264788627625,
-0.5031024813652039,
0.37063369154930115,
-0.12495696544647217,
-0.26499202847480774,
-0.06982900947332382,
-0.243228480219841,
-0.17874731123447418,
-0.1786719709634781,
-0.017094792798161507,
-0.16179612278938293,
0.20345869660377502,
-0.22723473608493805,
0.02616233564913273,
0.41939669847488403,
-0.15453611314296722,
0.05511032044887543,
-0.06182374060153961,
0.28309568762779236,
0.14103735983371735,
0.11720927804708481,
0.16958367824554443,
-0.85088711977005,
0.46649298071861267,
1.0521090030670166,
0.1965024322271347,
-0.36363229155540466,
-0.5989204049110413,
-0.016146687790751457,
-0.07064253091812134,
-1.1643205881118774,
-0.14112931489944458,
0.1906166821718216,
-0.5308616161346436,
0.19941768050193787,
-0.34230339527130127,
-0.06517572700977325,
0.08715945482254028,
-0.40976622700691223,
-0.3858695328235626,
-0.16348065435886383,
0.5042464137077332,
-0.026264240965247154,
0.17690269649028778,
-0.5743405818939209,
-0.22094744443893433,
-0.18970584869384766,
0.36422237753868103,
0.11072520911693573,
-0.1931883990764618,
-0.4912397861480713,
0.3136582672595978,
0.4207015037536621,
-0.35988226532936096,
-0.22823219001293182,
-0.36710360646247864,
-0.22458887100219727,
0.2007368803024292,
0.3466264009475708,
0.16586917638778687,
0.29456788301467896,
-0.12237834930419922,
-0.12144912779331207,
-0.38922762870788574,
-0.505599319934845,
0.12562142312526703,
0.24586522579193115,
-0.035620998591184616,
0.08707479387521744,
0.28927910327911377,
-0.554092526435852,
-0.05073215812444687,
0.30853205919265747,
-0.48178136348724365,
-0.07730128616094589,
-0.23273196816444397,
0.2915356457233429,
-0.550242006778717,
0.1392863243818283,
-0.37708190083503723,
-0.31376996636390686,
0.6539446115493774,
0.07628561556339264,
0.2908594608306885,
-0.31017550826072693,
-0.8299177289009094,
0.052489884197711945,
0.4618733525276184,
-0.05269896984100342,
0.03711313754320145,
0.0036848282907158136,
-0.43580397963523865,
-0.4560798108577728,
0.7206565141677856,
0.13918659090995789,
-0.9666402339935303,
0.027939263731241226,
-0.13853974640369415,
0.31915000081062317,
-0.40723079442977905,
0.20438916981220245,
0.25188833475112915,
-0.6125470995903015,
-0.22442714869976044,
0.37460917234420776,
-0.28010237216949463,
0.22406333684921265,
0.4729483723640442,
-0.16443541646003723,
0.06014511361718178,
-0.44178059697151184,
-0.6172066330909729,
-0.3874260187149048,
-0.47535690665245056,
0.5435659289360046,
-0.5389115214347839,
-0.2838996350765228,
0.21464820206165314,
-0.20795178413391113,
-0.09632443636655807,
0.10348830372095108,
-0.3612807095050812,
0.8626554012298584,
0.05262480303645134,
0.11516650766134262,
-0.29230165481567383,
-0.21055930852890015,
-0.6228719353675842,
-0.3226442039012909,
0.28546375036239624,
-0.4803384244441986,
0.3151355981826782,
-0.16878832876682281,
-0.3666074872016907,
-0.33808913826942444,
-0.6753457188606262,
0.23048771917819977,
-0.17949815094470978,
-0.40765300393104553,
-0.17001613974571228,
0.6968603134155273,
0.7280268669128418,
0.3827396333217621,
0.12120399624109268,
-0.36368703842163086,
-0.34778115153312683,
-0.43323761224746704,
0.41809114813804626,
-0.30867424607276917,
-0.16568779945373535,
0.29164835810661316,
-0.3646398186683655,
0.2521710693836212,
-0.5821314454078674,
0.10336166620254517,
-0.6987534165382385,
-0.03758002817630768,
-0.6339199542999268,
0.016267092898488045,
0.4093192517757416,
-0.4504146873950958,
-0.6067994832992554,
-0.14265765249729156,
0.31415319442749023,
0.012167348526418209,
0.2865225672721863,
-0.2806723415851593,
-0.3856998383998871,
-0.4538034498691559,
0.4586886763572693,
0.7183172702789307,
-0.0681680366396904,
-0.2334081381559372,
0.0454314760863781,
0.11445639282464981,
0.4173963963985443,
-0.05391361564397812,
0.07746300846338272,
0.37036606669425964,
0.18288898468017578,
0.11759576201438904,
0.28895503282546997,
-0.5747514963150024,
0.4006972312927246,
-0.2624535858631134,
-0.22552338242530823,
0.20968614518642426,
-0.042872700840234756,
0.44894662499427795,
0.6049482226371765,
0.33187136054039,
-0.39071089029312134,
-0.5935879945755005,
0.4989178478717804,
0.0017952752532437444,
0.32307901978492737,
0.1565343141555786,
0.47525614500045776,
0.6731019020080566,
0.30740267038345337,
-0.2633216381072998,
0.33353763818740845,
0.003544208128005266,
0.2361578345298767,
0.30217859148979187,
-0.5278857350349426,
-0.15221066772937775,
-0.009908460080623627,
1.0916774272918701,
-0.04673302546143532,
0.04319251701235771,
-0.05621219053864479,
-0.014006061479449272,
0.1086105927824974,
0.16113607585430145,
0.10350902378559113,
0.21071185171604156,
-0.014627605676651001,
0.2905704975128174,
-0.05761491507291794,
-0.21978700160980225,
0.344562828540802,
-0.17572098970413208,
0.10045592486858368,
0.12107441574335098,
-0.5426028966903687,
-0.15758483111858368,
-0.10022223740816116,
0.24834121763706207,
0.059077780693769455,
0.1461465060710907,
0.6833969354629517,
-0.0012091259704902768,
-0.030452771112322807,
0.37456414103507996,
0.14515677094459534,
-0.04419080540537834,
-0.2286706417798996,
0.2897733449935913,
-0.5605171918869019,
-0.1257447600364685,
0.44806087017059326,
0.5039788484573364,
-0.023027392104268074,
0.2261543571949005,
0.17274147272109985,
0.19212345778942108,
0.4800562262535095,
-0.7682382464408875,
-0.1619751900434494,
-0.22927381098270416,
-0.20334851741790771,
-0.20324960350990295,
-0.0859445258975029,
-0.2308729887008667,
-0.005123704206198454,
-0.06785087287425995,
-0.1778845489025116,
0.254967600107193,
-0.1312878280878067,
0.09707550704479218,
0.20083600282669067,
0.05460333079099655,
0.09240812063217163,
0.5033625364303589,
0.4907255172729492,
-0.22080959379673004,
0.6571362614631653,
0.11920171976089478,
-0.09905263781547546,
-0.3502313196659088,
0.5547654032707214,
-0.6550315618515015,
0.5285712480545044,
-0.2914751470088959,
0.16632334887981415,
-0.5146700143814087,
0.13206276297569275,
0.2758809030056,
0.8204132318496704,
-0.013260929845273495,
0.194004088640213,
-0.5615721940994263,
-0.33237791061401367,
0.547490119934082,
-0.41644904017448425,
-0.16270393133163452,
-0.6479399800300598,
-0.08735736459493637,
-0.17648765444755554,
0.19534604251384735,
-0.07520291954278946,
-0.49745723605155945,
0.038535840809345245,
0.49630698561668396,
0.5083157420158386,
0.2487189918756485,
0.4013121724128723,
-0.16901206970214844,
0.3534197211265564,
-0.1960926204919815,
0.0838611051440239,
-0.9858065843582153,
-0.21812745928764343,
0.0734943300485611,
0.3945155441761017,
-0.12193883955478668,
0.025121521204710007,
0.26304373145103455,
-0.2986568510532379,
-0.01991722173988819,
-0.1483616828918457,
0.38089480996131897,
-0.22872133553028107,
-0.1255401074886322,
-0.5050634741783142,
-0.09074252843856812,
0.18165141344070435,
0.16277025640010834,
-0.048230186104774475,
-0.33362889289855957,
-0.0214264914393425,
0.11213506758213043,
0.08028790354728699,
0.2703116834163666,
-0.07161147892475128,
0.2633780837059021,
0.2176155149936676
] |
INTRODUCTION: Multicentric Castleman's Disease (MCD), a lymphoproliferative disorder associated with Human Herpes Virus-8 (HHV-8) infection, is increasing in incidence amongst HIV patients. This condition is associated with lymphadenopathy, polyclonal gammopathy, hepato-splenomegaly and systemic symptoms. A number of small studies have demonstrated the efficacy of the anti-CD20 monoclonal antibody, rituximab, in treating this condition. CASE PRESENTATION: We report the case of a 46 year old Zambian woman who presented with pyrexia, diarrhoea and vomiting, confusion, lymphadenopathy, and renal failure. She rapidly developed multiple organ failure following the initiation of treatment of MCD with rituximab. Following admission to intensive care (ICU), she received prompt multi-organ support. After 21 days on the ICU she returned to the haematology medical ward, and was discharged in remission from her disease after 149 days in hospital. CONCLUSION: Rituximab, the efficacy of which has thus far been examined predominantly in patients outside the ICU, in conjunction with extensive organ support was effective treatment for MCD with associated multiple organ failure. There is, to our knowledge, only one other published report of its successful use in an ICU setting, where it was combined with cyclophosphamide, adriamycin and prednisolone. Reports such as ours support the notion that critically unwell patients with HIV and haematological disease can benefit from intensive care. | [
-0.00828976184129715,
0.0023868067655712366,
-0.0034901124890893698,
0.0021033480297774076,
-0.016349170356988907,
0.0007530064322054386,
0.008820028975605965,
0.007786435075104237,
-0.009266414679586887,
-0.02523108571767807,
-0.0027660541236400604,
0.006692464463412762,
0.003277644282206893,
0.028334565460681915,
-0.003945851698517799,
0.012028982862830162,
-0.025170307606458664,
0.013592900708317757,
0.011195840314030647,
-0.006593959406018257,
0.003180424217134714,
0.006045139394700527,
0.010754460468888283,
0.030713241547346115,
-0.018283113837242126,
0.018548857420682907,
-0.0024572955444455147,
0.013472303748130798,
-0.004154643043875694,
0.0018881428986787796,
-0.013210887089371681,
0.03086775913834572,
0.003893118817359209,
0.03408394753932953,
-0.002001421758905053,
0.012783912010490894,
-0.00009138381574302912,
0.016528643667697906,
0.0027334413025528193,
-0.00511157838627696,
0.0033048265613615513,
-0.013991083949804306,
0.00287695717997849,
-0.025784438475966454,
-0.008592342957854271,
-0.021379265934228897,
-0.002779210451990366,
-0.014838429167866707,
-0.0007964910473674536,
0.00879974290728569,
-0.010658714920282364,
0.00041063688695430756,
-0.0061776298098266125,
-0.03820861130952835,
-0.0059619783423841,
0.0004632747732102871,
0.01748252660036087,
-0.006724766455590725,
0.008766771294176579,
0.02372576668858528,
-0.011720465496182442,
0.011827334761619568,
-0.024664901196956635,
-0.014216789975762367,
0.0002098027616739273,
-0.06700725108385086,
0.01033172570168972,
0.004204355645924807,
-0.019842449575662613,
-0.002856421284377575,
0.034773871302604675,
0.0078424122184515,
0.03637988492846489,
0.002805606462061405,
0.005628239829093218,
-0.011456622742116451,
-0.009871338494122028,
0.02318163961172104,
-0.0019296279642730951,
0.004870764445513487,
0.00965498574078083,
-0.002686074236407876,
-0.00991010945290327,
0.011681190691888332,
0.027343742549419403,
0.0039936574175953865,
-0.03770449385046959,
0.0016196421347558498,
0.01998639479279518,
0.0004189237952232361,
0.010350784286856651,
-0.017510149627923965,
-0.025677604600787163,
0.0015083909966051579,
-0.010120794177055359,
-0.04015996307134628,
-0.012167657725512981,
0.0015908163040876389,
-0.023606548085808754,
-0.014024313539266586,
-0.01668662577867508,
0.007728728000074625,
0.014757153578102589,
0.00043114391155540943,
0.01106242649257183,
0.005073326174169779,
-0.016775215044617653,
0.009576761163771152,
0.020163623616099358,
0.015489503741264343,
-0.022510487586259842,
0.005733878817409277,
-0.014490963891148567,
0.0446375347673893,
0.030670244246721268,
0.010305115953087807,
0.0031538309995085,
0.008321178145706654,
0.017046310007572174,
0.03274437412619591,
0.0167895145714283,
0.008483952842652798,
0.00872872769832611,
-0.002675841562449932,
0.0020669482182711363,
0.0038550193421542645,
0.011601796373724937,
0.0023616550024598837,
0.011702008545398712,
0.008204893209040165,
-0.0036977832205593586,
0.008531657978892326,
-0.0033750394359230995,
-0.0041806017979979515,
0.0023432979360222816,
-0.005042087286710739,
-0.018979208543896675,
0.00021875370293855667,
0.003077717963606119,
-0.01848454773426056,
-0.004315581172704697,
0.0061061023734509945,
0.005447440315037966,
0.00969425868242979,
-0.01907125860452652,
0.011479463428258896,
-0.022858601063489914,
-0.000113676767796278,
0.002817342057824135,
-0.008101223967969418,
0.018402861431241035,
-0.0016205827705562115,
-0.016863394528627396,
-0.01939677633345127,
-0.008157087489962578,
0.01710977405309677,
-0.013740031979978085,
-0.02238551154732704,
-0.004590838216245174,
0.04273170977830887,
-0.023629724979400635,
-0.0048539177514612675,
0.010472644120454788,
0.010867247357964516,
0.020066378638148308,
0.020831266418099403,
-0.0065968455746769905,
-0.00783107802271843,
0.01748782768845558,
0.01248395349830389,
-0.00367661751806736,
-0.006552796810865402,
0.011287904344499111,
0.0086283627897501,
-0.0225287526845932,
-0.010559745132923126,
-0.01392443384975195,
0.005187157541513443,
-0.004406622610986233,
0.06574773788452148,
0.005125111434608698,
0.012378334067761898,
-0.002965550171211362,
-0.005791157484054565,
0.025855975225567818,
-0.016390100121498108,
-0.009864450432360172,
-0.004841182846575975,
-0.017078248783946037,
-0.03159705922007561,
0.012631809338927269,
-0.009464661590754986,
-0.025733035057783127,
0.02283589169383049,
0.0080996910110116,
0.003158777253702283,
0.00898272916674614,
0.00847603939473629,
-0.008043445646762848,
0.0033914505038410425,
0.0319940522313118,
-0.013226520270109177,
0.003746442496776581,
-0.04042297601699829,
0.013692520558834076,
0.010563259944319725,
0.0011472986079752445,
0.02561480924487114,
-0.02068212628364563,
-0.004759729374200106,
0.013347363099455833,
0.017066746950149536,
-0.010609183460474014,
0.001902498654089868,
-0.022897429764270782,
-0.003577565308660269,
-0.012640271335840225,
0.023910095915198326,
0.0067771244794130325,
-0.0057538291439414024,
-0.006879132241010666,
0.012371706776320934,
-0.02177818864583969,
0.003612976521253586,
0.000899280421435833,
-0.03164075314998627,
0.0032324260100722313,
0.00754532590508461,
-0.0045453207567334175,
-0.0075276074931025505,
-0.03659369796514511,
-0.00010923855006694794,
-0.0133759044110775,
0.013056502677500248,
0.012541012838482857,
-0.006725792773067951,
0.01505117118358612,
-0.016851507127285004,
0.02699829265475273,
-0.026043172925710678,
-0.021823545917868614,
-0.00870300829410553,
0.022897867485880852,
-0.009993216022849083,
0.03036949224770069,
0.001307428814470768,
0.006529223173856735,
0.02226926200091839,
0.015748944133520126,
-0.007413660641759634,
0.010943233966827393,
-0.021824514493346214,
-0.006947123445570469,
-0.005151290912181139,
-0.02561284974217415,
-0.015031513758003712,
-0.002049755770713091,
-0.014450556598603725,
0.024635925889015198,
-0.019418800249695778,
0.008065316826105118,
0.00573595380410552,
-0.012016858905553818,
-0.012602439150214195,
-0.0014318255707621574,
-0.01874373108148575,
0.02713686414062977,
0.006748884916305542,
-0.012430334463715553,
0.004928600043058395,
0.012172123417258263,
-0.0034353858791291714,
-0.007329780608415604,
-0.08071959018707275,
-0.02002580650150776,
-0.01774686761200428,
0.05469091981649399,
0.005537152290344238,
-0.01600443758070469,
0.0011168847559019923,
-0.006671363487839699,
-0.012181837111711502,
0.006154701579362154,
-0.006097851786762476,
0.012548910453915596,
-0.005471213720738888,
0.007226775866001844,
0.005970724858343601,
-0.007177458144724369,
0.01309159118682146,
-0.0037698615342378616,
0.005464266519993544,
-0.01041383296251297,
0.023074008524417877,
-0.01941847987473011,
0.037558745592832565,
0.018439216539263725,
-0.018265359103679657,
0.01528006512671709,
0.006392731796950102,
0.003983734175562859,
-0.009510756470263004,
-0.0027420436963438988,
0.024934936314821243,
-0.0031814039684832096,
-0.00028724735602736473,
-0.004536748398095369,
-0.007770662661641836,
-0.01865221932530403,
-0.019940219819545746,
-0.00519342627376318,
-0.007314193993806839,
0.012691489420831203,
-0.027474943548440933,
0.004925914574414492,
0.02459893375635147,
-0.006594122387468815,
0.003923480398952961,
0.005941855721175671,
0.04384336993098259,
0.019581619650125504,
0.01643969863653183,
-0.014105333015322685,
-0.02779250219464302,
0.0016624338459223509,
-0.009483504109084606,
0.013267723843455315,
-0.013449832797050476,
-0.019703753292560577,
-0.006461238954216242,
0.011460261419415474,
-0.004034601151943207,
-0.009713536128401756,
0.01922636106610298,
-0.043944332748651505,
0.03412055969238281,
-0.005966053809970617,
-0.019231034442782402,
0.014466915279626846,
0.009379023686051369,
-0.006769903935492039,
-0.020155830308794975,
-0.006019095424562693,
0.006925336085259914,
0.005796388722956181,
-0.002136104740202427,
-0.013643208891153336,
0.006143318489193916,
-0.00007804448250681162,
-0.014005418866872787,
-0.0017024478875100613,
-0.004954236559569836,
-0.03393213823437691,
-0.01565469428896904,
0.010502753779292107,
0.012544473633170128,
0.016074756160378456,
-0.0002399887889623642,
0.001958824461326003,
0.00459455419331789,
-0.0049994937144219875,
0.019346728920936584,
-0.015308719128370285,
-0.025987962260842323,
-0.0007591601461172104,
-0.022193605080246925,
0.014840337447822094,
-0.015160571783781052,
-0.006974481977522373,
0.017024552449584007,
-0.006665307562798262,
-0.004802824929356575,
0.006560460664331913,
0.00845398660749197,
-0.00033619930036365986,
-0.007554297801107168,
-0.0054840631783008575,
-0.0015963288024067879,
0.0168301984667778,
0.004488855600357056,
-0.01411719061434269,
0.0019102510996162891,
0.0014020978705957532,
0.02262839674949646,
-0.01608222723007202,
-0.005653921514749527,
0.019268320873379707,
0.008712256327271461,
0.021359097212553024,
0.015849729999899864,
0.006805574521422386,
0.07173401117324829,
0.009019019082188606,
-0.009311916306614876,
-0.009113001637160778,
0.0025162920355796814,
-0.026685573160648346,
-0.012756912969052792,
0.023760497570037842,
-0.01217690110206604,
0.028550654649734497,
0.012161493301391602,
-0.0040399241261184216,
-0.016336532309651375,
-0.016075603663921356,
-0.0047631217166781425,
0.005119845271110535,
-0.0011247689835727215,
-0.005854571238160133,
0.017695624381303787,
0.012478230521082878,
0.016328420490026474,
0.0028066253289580345,
-0.027104061096906662,
0.0012439924757927656,
0.01619204506278038,
0.0021149073727428913,
0.003534798976033926,
-0.013843444176018238,
-0.030160749331116676,
0.01368032768368721,
0.0009388658218085766,
0.00967121496796608,
-0.012183438055217266,
0.004163834266364574,
0.017734620720148087,
0.0025236126966774464,
0.010215355083346367,
0.004540418740361929,
0.021847892552614212,
-0.0037281885743141174,
-0.021740306168794632,
-0.018051443621516228,
-0.004485921934247017,
0.012489989399909973,
-0.009167083539068699,
-0.010610228404402733,
-0.009364997036755085,
-0.0036013948265463114,
-0.023448705673217773,
-0.011861719191074371,
0.002047983929514885,
-0.004298689775168896,
0.01925741136074066,
0.026742327958345413,
-0.008050616830587387,
0.005885227117687464,
-0.01621769368648529,
-0.025477364659309387,
0.012939754873514175,
0.0062835849821567535,
0.009467631578445435,
-0.009826790541410446,
0.017527952790260315,
0.011217882856726646,
-0.00638932827860117,
-0.005819648504257202,
0.016588829457759857,
0.013770867139101028,
-0.02301885560154915,
-0.028544697910547256,
0.0019932289142161608,
-0.018071308732032776,
-0.018469203263521194,
-0.0016855988651514053,
-0.025590933859348297,
0.0264519564807415,
-0.017221743240952492,
-0.017327923327684402,
0.03307095542550087,
-0.007867153733968735,
-0.007541464641690254,
0.015561262145638466,
-0.0012586014345288277,
0.0017254655249416828,
0.010204741731286049,
-0.004313272424042225,
-0.002851516706869006,
-0.07447339594364166,
-0.008392691612243652,
-0.055136509239673615,
-0.00530315563082695,
0.02454955317080021,
-0.005577363073825836,
-0.025576196610927582,
-0.001214432530105114,
0.0005927104502916336,
0.002307735849171877,
0.005636604968458414,
0.01728089712560177,
-0.011425666511058807,
-0.004256158601492643,
0.010277311317622662,
0.004007718525826931,
0.0003464920446276665,
-0.0014634416438639164,
-0.040464501827955246,
0.009837496094405651,
0.009409353137016296,
-0.018556730821728706,
-0.0440298393368721,
-0.0039054052904248238,
-0.01789659634232521,
-0.08071357756853104,
-0.008510615676641464,
-0.01585998386144638,
-0.014954834245145321,
-0.007424803450703621,
-0.00572621263563633,
-0.0018474445678293705,
-0.01801619678735733,
-0.027153480798006058,
-0.014707563444972038,
0.012913711369037628,
0.015515046194195747,
0.001980634406208992,
-0.014300413429737091,
0.013376690447330475,
-0.011264471337199211,
0.031275972723960876,
0.029063241556286812,
-0.017968757078051567,
0.017590193077921867,
-0.007917257957160473,
0.021447332575917244,
-0.006457495968788862,
-0.004126289859414101,
-0.007854513823986053,
-0.02496316470205784,
-0.003772581461817026,
0.016918044537305832,
-0.019328473135828972,
0.012364725582301617,
-0.0036753506865352392,
-0.010821834206581116,
-0.02095703035593033,
-0.001793143805116415,
-0.02401953563094139,
-0.020630110055208206,
0.010092563927173615,
0.0018781388644129038,
0.021073659881949425,
-0.02365264855325222,
-0.00439814105629921,
0.017882125452160835,
-0.013493543490767479,
-0.01017183717340231,
-0.008198403753340244,
-0.003569797147065401,
0.0031127617694437504,
-0.0055620563216507435,
0.0004374696873128414,
-0.028769567608833313,
0.0021313840989023447,
0.014985580928623676,
0.01587061583995819,
0.006313050165772438,
0.021604645997285843,
-0.002989321481436491,
-0.007383875548839569,
0.014646647498011589,
0.020054828375577927,
-0.002340982435271144,
0.00047478429041802883,
-0.0002921463456004858,
0.019260060042142868,
0.07109972089529037,
-0.04718539118766785,
0.010548773221671581,
-0.006252286024391651,
0.0019315779209136963,
0.008709982968866825,
-0.0295395664870739,
0.0255450289696455,
-0.008455762639641762,
-0.01995551772415638,
-0.013646578416228294,
-0.014720426872372627,
-0.03171857073903084,
0.008732467889785767,
-0.006570835597813129,
-0.001569629181176424,
0.014026260003447533,
0.004214072600007057,
0.03165234997868538,
-0.017889121547341347,
0.02623092196881771,
-0.0072938078083097935,
-0.008902101777493954,
0.03837335854768753,
0.02262498065829277,
-0.011686082929372787,
0.0013123378157615662,
0.007314279675483704,
-0.031372249126434326,
-0.009715145453810692,
-0.014007382094860077,
0.02701118029654026,
0.0013096932088956237,
0.015432356856763363,
0.004910196177661419,
0.027582654729485512,
-0.0278615765273571,
0.014618326909840107,
-0.021808423101902008,
0.02004183642566204,
0.01582477241754532,
0.005478363949805498,
-0.00856319721788168,
-0.004240610171109438,
0.02137736603617668,
0.008297832682728767,
-0.003587170969694853,
0.006301813293248415,
-0.026092449203133583,
0.008655323646962643,
-0.010442443192005157,
-0.00453190878033638,
0.025652121752500534,
0.006702164188027382,
0.009729217737913132,
0.006772973574697971,
-0.017939232289791107,
0.008649799972772598,
0.004430969711393118,
-0.014510887674987316,
0.03453651815652847,
-0.0168901514261961,
-0.01451850775629282,
-0.0201835036277771,
0.016496000811457634,
0.025164194405078888,
0.02962516061961651,
-0.018933186307549477,
-0.0034135691821575165,
0.010123534128069878,
0.003375527448952198,
-0.003686466719955206,
0.013990775682032108,
-0.006865551695227623,
0.00047059589996933937,
0.004211911931633949,
0.021443355828523636,
0.0027748383581638336,
0.0074025471694767475,
0.022836163640022278,
0.0010497316252440214,
-0.035984233021736145,
0.007720137946307659,
-0.021130364388227463,
0.0007214909419417381,
0.019261043518781662,
-0.009392043575644493,
0.02487962879240513,
-0.004229645244777203,
0.003410997800529003,
0.04068424180150032,
0.0035720779560506344,
0.006719468627125025,
0.008870650082826614,
0.014088621363043785,
0.03309566155076027,
0.0004603188717737794,
-0.002380826510488987,
-0.003957266919314861,
-0.00701276445761323,
0.0015807989984750748,
-0.05697605386376381,
-0.011008350178599358,
0.025881433859467506,
-0.01677464134991169,
0.006235978566110134,
-0.004103445447981358,
0.016217289492487907,
-0.008641637861728668,
0.0393143892288208,
-0.004791161976754665,
-0.008913972415030003,
0.014597859233617783,
-0.003761572763323784,
0.02106611803174019,
0.028325673192739487,
-0.016654150560498238,
0.009357319213449955,
0.0031482919584959745,
-0.02150329388678074,
-0.006827972829341888,
-0.010733040049672127,
0.0271315798163414,
0.009285272099077702,
0.012770965695381165,
-0.01094019040465355,
-0.008351501077413559,
-0.00448166998103261,
-0.00972733274102211,
0.002188566140830517,
0.00811066571623087,
-0.0064208670519292355,
-0.013367626816034317,
0.011514166370034218,
-0.005427269265055656,
-0.005728342570364475,
0.003558058524504304,
0.03884406387805939,
-0.00009287334978580475,
-0.01491681206971407,
0.01845194399356842,
-0.020078683272004128,
-0.0022059325128793716,
-0.014941876754164696,
0.00948486477136612,
-0.002511361613869667,
-0.01744040846824646,
0.00953194685280323,
0.01097586378455162,
-0.00045941933058202267,
0.010654876939952374,
-0.01924815960228443,
-0.0008330522105097771,
-0.011400965042412281,
0.0002727028913795948,
0.017398890107870102,
0.013979409821331501,
-0.006614728830754757,
-0.0164248738437891,
0.02503770776093006,
-0.015995623543858528,
0.004508456215262413,
-0.0052300794050097466,
-0.0011704624630510807,
-0.00690095592290163,
0.02746783010661602,
-0.01735207810997963,
-0.002917633857578039,
0.03357461839914322,
-0.01596253551542759,
0.03252749890089035,
0.008581666275858879,
-0.014680725522339344,
0.016521848738193512,
-0.03948462754487991,
-0.0015819387044757605,
0.009147480130195618,
-0.009090796113014221,
-0.010071135126054287,
0.009399761445820332,
-0.00887515302747488,
0.02079850062727928,
0.01405574381351471,
-0.010890831239521503,
0.015093172900378704,
-0.005127827171236277,
-0.020672932267189026,
0.02010880783200264,
-0.02389448881149292,
0.00815807655453682,
0.01802343875169754,
0.025546882301568985,
0.0028288583271205425,
-0.022524360567331314,
0.010982275009155273,
0.01865914836525917,
0.00020098057575523853,
0.010835003107786179,
-0.0002293633297085762,
-0.001201475621201098,
0.025252263993024826,
-0.02337634190917015
] | [
0.33005931973457336,
0.18927109241485596,
0.3177264630794525,
0.016086317598819733,
0.17834609746932983,
-0.011206792667508125,
0.19895458221435547,
-0.13456416130065918,
-0.4904659390449524,
-0.0070849270559847355,
-0.2891816198825836,
-0.02152373641729355,
-0.10490849614143372,
0.3408123850822449,
0.05946788191795349,
1.0380390882492065,
0.441549152135849,
0.1950993835926056,
-0.46180760860443115,
-0.38519832491874695,
0.025221804156899452,
-0.32475143671035767,
0.5818243622779846,
0.04615792632102966,
0.11193907260894775,
-0.015485621988773346,
0.4956228733062744,
-0.1313573122024536,
-0.049131497740745544,
-0.34965118765830994,
0.34154456853866577,
0.2814825773239136,
0.5153579711914062,
-0.14894592761993408,
-0.09685897827148438,
0.10454576462507248,
-0.18718692660331726,
-0.23643802106380463,
0.12199734896421432,
-0.5658432245254517,
0.032173044979572296,
0.17532311379909515,
0.27602043747901917,
0.4968092441558838,
-0.01156314555555582,
-0.44472670555114746,
-1.557160496711731,
0.5698914527893066,
-0.35441502928733826,
0.04152917489409447,
0.007354430388659239,
0.3727363348007202,
0.5539379119873047,
-0.08667372167110443,
0.02587823010981083,
-0.1091114953160286,
-0.5732254385948181,
-0.6377670168876648,
0.36604490876197815,
-0.36759793758392334,
0.4440496861934662,
-0.17156337201595306,
0.13488340377807617,
0.15463730692863464,
-0.24354179203510284,
0.34635230898857117,
-0.06536486744880676,
0.4407287538051605,
0.0939372107386589,
-0.31255653500556946,
0.35096365213394165,
-0.4860948324203491,
0.0897451862692833,
0.07736247777938843,
0.2524647116661072,
-0.12744386494159698,
-0.22646956145763397,
-0.29768386483192444,
0.4218485355377197,
-0.23920951783657074,
-0.36329102516174316,
-0.1229429617524147,
0.4557412564754486,
-0.5551046133041382,
0.7067884802818298,
0.00538623658940196,
-0.10158044844865799,
0.696081280708313,
-0.5650973320007324,
-0.09084610641002655,
-0.5376964211463928,
-0.31308919191360474,
0.3416171669960022,
0.8519836664199829,
0.2215987741947174,
-0.4118345081806183,
0.017293380573391914,
-0.36985570192337036,
0.3928793966770172,
0.05655810981988907,
0.1387416273355484,
0.3269469439983368,
-0.004104806575924158,
-0.17274978756904602,
-0.44849762320518494,
0.1458192765712738,
-0.2059544324874878,
-0.6664379239082336,
-0.5216891169548035,
0.20313137769699097,
-0.5312373042106628,
-0.33944687247276306,
-0.37176311016082764,
-0.28438353538513184,
-0.24004851281642914,
0.5542147159576416,
0.0727110207080841,
-0.29655447602272034,
-0.12064056843519211,
0.29387280344963074,
-0.24516716599464417,
0.6131536364555359,
-0.5039811730384827,
0.8366638422012329,
0.5344653725624084,
-0.016308793798089027,
0.1779240220785141,
0.32922670245170593,
-0.10084555298089981,
0.637109100818634,
0.19383113086223602,
0.38800132274627686,
-0.2694755494594574,
0.011382297612726688,
-0.10009575635194778,
-0.1676308810710907,
-0.0445241741836071,
0.13779373466968536,
0.008065614849328995,
0.390123188495636,
0.05513427406549454,
-0.24920113384723663,
-0.1931626945734024,
0.3740932047367096,
0.09462123364210129,
0.0319710299372673,
-0.2968690097332001,
0.26803353428840637,
0.011497166007757187,
-0.355684369802475,
-0.16920174658298492,
0.17405100166797638,
-0.3135605454444885,
-0.08123815059661865,
0.22743983566761017,
0.49373170733451843,
-0.3376077711582184,
-0.26319679617881775,
-0.13217709958553314,
0.4836355149745941,
0.6314995884895325,
0.589330792427063,
0.0771978497505188,
-0.1206333115696907,
0.2749999463558197,
-0.1244717389345169,
0.16360831260681152,
0.25611424446105957,
0.46264997124671936,
-0.4545973837375641,
-0.4969114065170288,
-0.11065217107534409,
-0.20433034002780914,
-0.5607746243476868,
0.17818790674209595,
0.8670090436935425,
0.582927405834198,
0.18155784904956818,
0.11946743726730347,
0.39577993750572205,
-0.5975351929664612,
-0.3424527943134308,
-0.5849144458770752,
-0.7713562846183777,
0.40809574723243713,
-0.1845681369304657,
0.23217736184597015,
0.36321955919265747,
0.46984919905662537,
0.54997718334198,
-0.17107003927230835,
-0.08347394317388535,
0.5814341306686401,
-0.3654576539993286,
1.2317627668380737,
-0.07608208805322647,
-0.25916624069213867,
1.1356209516525269,
0.2372162938117981,
0.12632064521312714,
-0.15092962980270386,
0.9313897490501404,
0.7670153379440308,
0.22467727959156036,
-0.5816522836685181,
0.016123531386256218,
-0.09584391862154007,
-0.007892930880188942,
-0.29580754041671753,
0.1267239898443222,
0.11931587755680084,
-0.13488931953907013,
-0.06591830402612686,
-0.24930930137634277,
0.5869033336639404,
0.434822678565979,
0.14718201756477356,
-0.08071300387382507,
-0.2985694110393524,
0.12878380715847015,
0.681154727935791,
-0.24424272775650024,
0.35079845786094666,
0.7255899906158447,
-0.14066220819950104,
0.7362750172615051,
0.753537118434906,
-0.12924331426620483,
0.8629967570304871,
-0.6136810183525085,
-0.32557713985443115,
0.020079243928194046,
0.33594372868537903,
-0.47059717774391174,
-0.178268164396286,
0.09675480425357819,
-0.2824706435203552,
-0.15311971306800842,
-0.2986159920692444,
0.1989089995622635,
0.13403430581092834,
0.012244163081049919,
-0.5786811709403992,
0.14194364845752716,
0.059440065175294876,
-0.07630805671215057,
-0.4043111801147461,
0.14634433388710022,
-0.6262632012367249,
0.25940200686454773,
0.42431408166885376,
0.5176897644996643,
0.32782039046287537,
-0.2893911898136139,
-0.01760176196694374,
0.22219079732894897,
-0.34290459752082825,
-0.3012285530567169,
0.3465227484703064,
0.005096463952213526,
-0.2754289209842682,
0.21533748507499695,
-0.27397459745407104,
0.3531539738178253,
-0.044433820992708206,
-0.3935248553752899,
-0.6329416036605835,
-0.5642899870872498,
0.5807850360870361,
-0.1270173192024231,
-0.0407123863697052,
-0.27493050694465637,
-0.4764687716960907,
0.2230939269065857,
0.023747801780700684,
-0.2744026184082031,
0.5247327089309692,
0.7818912267684937,
-0.41582581400871277,
-0.5345396399497986,
-0.4690726101398468,
0.5570444464683533,
0.5163244605064392,
-0.38199108839035034,
0.0061751543544232845,
0.0537639744579792,
-0.3061489462852478,
-0.483646422624588,
-0.5353502631187439,
-0.4927464425563812,
0.05011861026287079,
0.39737024903297424,
0.15286360681056976,
-0.047951921820640564,
0.4075990915298462,
0.35423532128334045,
0.028285130858421326,
0.3058203160762787,
0.17102690041065216,
0.018149446696043015,
0.20974545180797577,
0.7390829920768738,
-0.18919311463832855,
0.2781822383403778,
0.5265264511108398,
-0.24719847738742828,
-0.2118452489376068,
0.3725486099720001,
-6.141008377075195,
0.28566235303878784,
-0.18989287316799164,
-0.3456555902957916,
-0.27536675333976746,
-0.13575749099254608,
0.8236251473426819,
-0.13889533281326294,
0.21658827364444733,
0.023583006113767624,
-0.19777534902095795,
0.47085151076316833,
-0.05383496731519699,
-0.0759759470820427,
-0.022573966532945633,
0.33062127232551575,
-0.18301570415496826,
-0.2548905909061432,
0.23622804880142212,
0.6482521891593933,
0.04657658562064171,
0.0017210111254826188,
-0.2041327804327011,
0.2390502691268921,
-0.0889715701341629,
0.46750447154045105,
-0.5349584817886353,
0.4410645365715027,
-0.21628287434577942,
-0.08041095733642578,
0.2766162157058716,
-0.38400891423225403,
-0.18103308975696564,
-0.22324305772781372,
-0.3877209424972534,
0.2094677984714508,
0.2202664315700531,
-0.11915677040815353,
-0.08600729703903198,
-0.31643441319465637,
-0.09471563994884491,
0.09227757900953293,
0.18954098224639893,
-0.10423848032951355,
0.19310729205608368,
-0.07796432822942734,
-0.20285364985466003,
-0.1195656806230545,
-0.3641490340232849,
0.9938541054725647,
-0.023163245990872383,
-0.34804102778434753,
0.4272216856479645,
0.7355129718780518,
-0.06638416647911072,
-0.135518878698349,
-0.4136580526828766,
0.2624853551387787,
-0.5061483383178711,
-0.1740066260099411,
-0.17870458960533142,
-0.06902249902486801,
-0.05871693417429924,
-0.4533935487270355,
0.4411524832248688,
-0.06935784220695496,
-0.7989974021911621,
-0.03016272373497486,
0.06151428446173668,
-0.28575626015663147,
-0.5356682538986206,
0.14144960045814514,
0.059364430606365204,
-0.7167869210243225,
0.03416399657726288,
-0.7775538563728333,
0.07102292776107788,
-0.1653091311454773,
-0.03578267991542816,
-0.017186496406793594,
0.10637453943490982,
-0.2527618706226349,
0.13229674100875854,
-0.3932514190673828,
-0.07557513564825058,
-0.6424474120140076,
0.22070103883743286,
0.05775617063045502,
-0.1303236335515976,
0.3539581894874573,
-0.0038321595638990402,
0.1898004114627838,
-0.22310608625411987,
0.40736162662506104,
0.5675217509269714,
0.5880273580551147,
0.15036244690418243,
0.12204951792955399,
0.22354456782341003,
-0.03990553691983223,
0.8683403134346008,
-0.5406787991523743,
-0.1788158416748047,
-0.8418089747428894,
0.10547391325235367,
-0.07290323823690414,
-0.26062822341918945,
-0.07520673424005508,
0.20221522450447083,
-0.3428013324737549,
-0.07688000798225403,
-0.3285812437534332,
-0.6486166715621948,
0.06366828829050064,
0.7035876512527466,
0.04729346185922623,
0.26234734058380127,
-0.27696678042411804,
0.3828834593296051,
-0.18873444199562073,
0.2724626064300537,
0.28378212451934814,
-0.3775046169757843,
0.6016976237297058,
0.21457134187221527,
-0.09885084629058838,
0.2692866325378418,
0.3865317702293396,
-0.22704072296619415,
0.0356881283223629,
0.05717543512582779,
0.3253876566886902,
-0.22398898005485535,
-0.09417935460805893,
0.6154430508613586,
-0.19788102805614471,
-0.43222177028656006,
0.09431654959917068,
0.20032663643360138,
0.298453152179718,
0.23341280221939087,
-0.3174254298210144,
-0.39426374435424805,
0.12267492711544037,
-0.4180215001106262,
-0.11395194381475449,
-0.37020471692085266,
0.24234697222709656,
-0.3180500268936157,
0.11014391481876373,
0.02395710162818432,
0.2691034972667694,
0.21960552036762238,
-0.07148196548223495,
-0.4797550141811371,
0.21097394824028015,
0.44379812479019165,
0.29640963673591614,
0.17038613557815552,
-0.19344842433929443,
-0.008694091811776161,
0.08089505881071091,
-1.1231518983840942,
-0.060331255197525024,
0.554707944393158,
-0.08851777762174606,
0.25851887464523315,
-0.7234536409378052,
0.0721852108836174,
0.3675086796283722,
-0.17680740356445312,
0.028533169999718666,
-0.3968687355518341,
-0.04267602041363716,
0.7976083159446716,
0.24378490447998047,
-0.2529963552951813,
-0.5637591481208801,
0.29192012548446655,
0.39510786533355713,
0.2604786157608032,
-0.27680301666259766,
-0.09558691829442978,
0.6642052531242371,
0.8804417252540588,
0.0979880541563034,
-0.1036483645439148,
-0.35431575775146484,
0.26182445883750916,
-0.1925429105758667,
0.7435793876647949,
0.3521712124347687,
0.14289091527462006,
0.48406559228897095,
-0.2392994910478592,
-0.23040150105953217,
0.02328748255968094,
0.024081923067569733,
-0.09490994364023209,
-0.1188778504729271,
-0.2522405982017517,
0.2806025743484497,
0.3396247923374176,
0.35210660099983215,
0.7192704677581787,
-0.37347108125686646,
0.3333470821380615,
-0.4377480447292328,
-0.5342702269554138,
-0.24567675590515137,
-0.02448970265686512,
-0.46422332525253296,
-0.1936763972043991,
0.16990332305431366,
-0.040663961321115494,
0.2517092227935791,
-0.4600851237773895,
-0.7356160879135132,
-0.21954314410686493,
0.49910011887550354,
-0.1862005889415741,
-0.32401570677757263,
0.0018608367536216974,
-0.4042629301548004,
0.040924787521362305,
0.2939232885837555,
0.6044790744781494,
-0.8298335671424866,
-0.11026867479085922,
0.1864621788263321,
-0.275422602891922,
-0.19695088267326355,
-0.116710364818573,
0.0959494486451149,
-0.5367423295974731,
0.06048839911818504,
-0.2658799886703491,
0.01831343211233616,
0.206228569149971,
0.47660037875175476,
-0.023574264720082283,
0.36851364374160767,
-0.3181385099887848,
-0.2167222797870636,
0.023045750334858894,
-0.02774527110159397,
0.017521977424621582,
-0.16475065052509308,
-0.33414226770401,
0.20347735285758972,
-0.12369512021541595,
0.08827214688062668,
0.2641884684562683,
-0.36634761095046997,
0.5098592638969421,
-0.26164719462394714,
-0.09499732404947281,
-0.6875550150871277,
0.03283162787556648,
0.22383363544940948,
-0.4405653476715088,
-0.1721593290567398,
0.23868705332279205,
-0.2330949902534485,
0.16124679148197174,
-0.1298840045928955,
-0.3160833716392517,
-0.593123197555542,
0.31316858530044556,
-0.287075400352478,
-0.6653177738189697,
-0.20058105885982513,
0.25884655117988586,
0.16586574912071228,
-0.05269503965973854,
-0.05156346410512924,
-0.6070349216461182,
-0.5733935832977295,
-0.4200880229473114,
0.7016857862472534,
-0.1553301066160202,
-0.14855307340621948,
-0.29520145058631897,
0.1760779470205307,
0.5069231390953064,
-0.2436889261007309,
-0.049795620143413544,
0.08713877201080322,
0.23149168491363525,
-0.25761133432388306,
-0.07518511265516281,
0.39200296998023987,
-0.5312516689300537,
-0.25752556324005127,
0.43185925483703613,
0.09091629087924957,
0.15400578081607819,
0.00927137304097414,
-0.12040306627750397,
-0.1318318098783493,
-0.2906162142753601,
0.4915672838687897,
0.2851817011833191,
-0.23189616203308105,
0.19372019171714783,
-0.12704594433307648,
-0.22254613041877747,
0.35435497760772705,
-0.30235010385513306,
0.6543272733688354,
0.08689641207456589,
-0.08526204526424408,
0.21528998017311096,
0.15486417710781097,
-0.6266701221466064,
0.1740415245294571,
-0.1453753113746643,
-0.39418625831604004,
0.35506996512413025,
-0.265805721282959,
0.04626255854964256,
0.8240549564361572,
0.48002052307128906,
-0.03586547076702118,
-0.27291691303253174,
0.5024129748344421,
-0.21114526689052582,
0.32154878973960876,
-0.5759653449058533,
0.05351367965340614,
0.4976307451725006,
0.8225404024124146,
-0.16250871121883392,
0.12234792113304138,
0.3938808739185333,
0.2825862765312195,
0.7414969801902771,
-0.24979263544082642,
0.08467401564121246,
-0.30276617407798767,
0.17564068734645844,
0.23781099915504456,
-0.3790304958820343,
0.054328035563230515,
-0.36424922943115234,
0.017738960683345795,
-0.1773802489042282,
-0.0013854022836312652,
-0.07516840100288391,
0.18941792845726013,
0.5242605805397034,
0.28379058837890625,
-0.3119441866874695,
-0.5047708749771118,
-0.30695199966430664,
0.29098984599113464,
-0.1346212923526764,
-0.3411981165409088,
-0.7544434666633606,
-0.11287364363670349,
0.06682553887367249,
0.35779234766960144,
-0.3263968229293823,
0.47031164169311523,
0.009327917359769344,
-0.1576952040195465,
0.1352211982011795,
-0.1535419523715973,
0.10975894331932068,
-0.2612151503562927,
0.03975679725408554,
-0.527823805809021,
-0.2701561748981476,
0.2113337516784668,
0.03986816853284836,
-0.5876564383506775,
0.0017100893892347813,
-0.0855335146188736,
-0.24410611391067505,
0.916493833065033,
-0.38356009125709534,
-0.3628263473510742,
-0.4518486559391022,
-0.31356000900268555,
0.07718357443809509,
-0.21372433006763458,
0.38623708486557007,
0.34002527594566345,
-0.1178283765912056,
-0.03378309682011604,
0.06611299514770508,
-0.6796163320541382,
-0.6008635759353638,
0.41727930307388306,
-0.03560848906636238,
0.004092603921890259,
-0.15451571345329285,
0.528242290019989,
0.22562502324581146,
0.568604052066803,
-0.2241317331790924,
-0.31303486227989197,
0.011972333304584026,
0.013079498894512653,
-0.19416141510009766,
0.23340602219104767,
-0.26302456855773926,
-0.026896659284830093,
-0.9566253423690796,
-0.29329821467399597,
0.597338080406189,
0.5052529573440552,
-0.47084978222846985,
0.1810324490070343,
-0.188578799366951,
0.04645742475986481,
0.18340571224689484,
-0.30069056153297424,
-0.04844287782907486,
-0.3728296458721161,
-0.680038332939148,
-0.2766880691051483,
0.7107667326927185,
0.048140477389097214,
-0.33942079544067383,
-0.10601615905761719,
-0.06360485404729843,
0.27269336581230164,
-0.23517398536205292,
0.3652101457118988,
0.04518071934580803,
-0.29712778329849243,
-0.22327439486980438,
0.525336503982544,
-0.30430343747138977,
-0.249604731798172,
0.45824894309043884,
0.15137620270252228,
-0.16198444366455078,
0.11922040581703186,
-0.04779593646526337,
-0.41477102041244507,
-0.08604038506746292,
-0.3392089605331421,
-0.2914818227291107,
0.6754148006439209,
-0.22815357148647308,
0.2939367890357971,
-0.36338526010513306,
0.023859145119786263,
-0.1561965048313141,
-0.1923276036977768,
-0.6912649869918823,
-0.5868752002716064,
-0.07453077286481857,
-0.013110802508890629,
-0.6303390860557556,
-0.3580099642276764,
0.10405385494232178,
-0.16555416584014893
] |
In this study, specific sequences within three genes (3D, VP4 and 2B) of the foot-and-mouth disease virus (FMDV) genome were determined to be effective RNAi targets. These sequences are highly conserved among different serotype viruses based on sequence analysis. Small interfering RNA (siRNA)-expressing plasmids (p3D-NT19, p3D-NT56, pVP4-NT19, pVP4-NT65 and p2B-NT25) were constructed to express siRNA targeting 3D, VP4 and 2B, respectively. The antiviral potential of these siRNA for various FMDV isolates was investigated in baby hamster kidney (BHK-21) cells and suckling mice. The results show that these siRNA inhibited virus yield 10- to 300-fold for different FMDV isolates of serotype O and serotype Asia I at 48 h post infection in BHK-21 cells compared to control cells. In suckling mice, p3D-NT56 and p2B-NT25 delayed the death of mice. Twenty percent to 40% of the animals that received a single siRNA dose survived 5 days post infection with serotype O or serotype Asia I. We used an attenuated Salmonella choleraesuis (C500) vaccine strain, to carry the plasmid that expresses siRNA directed against the polymerase gene 3D (p3D-NT56) of FMDV. We used guinea pigs to evaluate the inhibitory effects of recombinant S. cho (p3D-NT56/S. cho) on FMDV infection. The results show that 80% of guinea pigs inoculated with 10(9) CFU of p3D-NT56/S. cho and challenged 36 h later with 50 ID(50) of homologous FMDV were protected. We also measured the antiviral activity of p3D-NT56/S. cho in swine. The results indicate that 100% of the animals treated with 5 × 10(9) CFU of p3D-NT56/S. cho were protected in 9 days. | [
-0.0020941942930221558,
0.010646983049809933,
-0.010208746418356895,
0.014416358433663845,
-0.0044850236736238,
-0.0011419204529374838,
0.007779350504279137,
0.013607947155833244,
-0.009075840935111046,
-0.009546345099806786,
-0.021242719143629074,
0.006582914851605892,
-0.01496998593211174,
0.012305309064686298,
-0.009092298336327076,
-0.0031153999734669924,
-0.015956193208694458,
0.0015366377774626017,
0.011601800099015236,
0.01712813414633274,
0.012050466611981392,
0.001945924130268395,
0.007993862964212894,
0.005105775780975819,
-0.00987277366220951,
0.007103827781975269,
0.009096618741750717,
-0.015087353065609932,
-0.011110648512840271,
0.0006798310205340385,
0.00415956461802125,
-0.0001223296858370304,
0.024661464616656303,
0.013173305429518223,
0.007701336406171322,
-0.00023211544612422585,
-0.004467704799026251,
0.01413760520517826,
0.025771815329790115,
-0.003745327703654766,
0.003399687586352229,
-0.011019768193364143,
0.0021353934425860643,
-0.009198513813316822,
-0.006896696984767914,
0.0046984246000647545,
-0.003386411117389798,
0.021308831870555878,
-0.010537387803196907,
0.004931878298521042,
-0.010212918743491173,
-0.015235715545713902,
-0.014905341900885105,
0.022972850129008293,
-0.004771166015416384,
-0.0002974469680339098,
0.013327131979167461,
-0.0042586177587509155,
0.0036246487870812416,
0.020321546122431755,
0.004255309235304594,
-0.0007930940482765436,
0.0034016133286058903,
-0.011011632159352303,
-0.022304043173789978,
-0.0674365758895874,
0.02361801080405712,
0.01911073364317417,
-0.0007852569688111544,
0.01716425269842148,
0.011393007822334766,
0.010102581232786179,
-0.011934712529182434,
-0.005889822728931904,
0.004834246356040239,
0.006472354754805565,
-0.008761601522564888,
0.018634354695677757,
0.0137338787317276,
0.003293636254966259,
-0.0038117985241115093,
0.0022854155395179987,
-0.011473138816654682,
0.004278070293366909,
-0.00989607721567154,
0.023622862994670868,
-0.020956598222255707,
-0.012796053662896156,
-0.007639261428266764,
-0.008925337344408035,
0.002947582397609949,
0.017326705157756805,
-0.019139371812343597,
-0.002493622014299035,
-0.02281683124601841,
0.007915303111076355,
0.0014942614361643791,
-0.013324420899152756,
-0.0015374801587313414,
-0.004960592836141586,
-0.012330768629908562,
-0.017806675285100937,
0.012608629651367664,
0.016122739762067795,
-0.02590097300708294,
0.0037035143468528986,
0.02328694984316826,
-0.0028654178604483604,
0.01741083711385727,
0.007155241444706917,
0.013828184455633163,
-0.0017896518111228943,
0.007808921858668327,
0.012142729945480824,
0.008102739229798317,
-0.000563538633286953,
-0.005564814433455467,
0.024394769221544266,
0.011108189821243286,
0.000764243770390749,
-0.009048664942383766,
-0.029504116624593735,
-0.002662369515746832,
-0.00007438752800226212,
0.005110650323331356,
-0.01829608529806137,
0.005499895196408033,
0.0016837480943650007,
-0.012385793961584568,
0.00896989181637764,
-0.006261449307203293,
0.008357425220310688,
-0.010592896491289139,
-0.013132767751812935,
-0.0013234089128673077,
-0.00005508400499820709,
-0.004875140264630318,
-0.01257435791194439,
0.005497216247022152,
-0.016672592610120773,
-0.010021504014730453,
0.009291804395616055,
0.002550360979512334,
0.015544353984296322,
0.016596060246229172,
0.006110308691859245,
0.01368778571486473,
-0.0018843556754291058,
0.03249560669064522,
-0.010977051220834255,
-0.0047397306188941,
-0.00220461655408144,
-0.005257848184555769,
-0.012412898242473602,
0.01117810420691967,
-0.004434380680322647,
-0.017324302345514297,
-0.022960491478443146,
-0.00934155285358429,
-0.00859888456761837,
0.00986918993294239,
0.004084459505975246,
0.004013433121144772,
0.008472291752696037,
-0.005859746597707272,
-0.02506660670042038,
-0.010407027788460255,
-0.01036546379327774,
0.004862557165324688,
0.0030766543932259083,
0.002423753496259451,
-0.007635009940713644,
0.00035661831498146057,
0.007289663888514042,
-0.03086964413523674,
0.0010657142847776413,
-0.00036130775697529316,
0.004401941783726215,
-0.018475588411092758,
0.06678745895624161,
0.0008591949008405209,
-0.009418031200766563,
0.01974233239889145,
0.0006138170138001442,
-0.005394698120653629,
-0.023796027526259422,
0.006790295243263245,
-0.010636640712618828,
-0.0078049106523394585,
0.01574542373418808,
0.008626226335763931,
0.013821318745613098,
-0.008274221792817116,
0.009220140986144543,
-0.005482378415763378,
0.0017110416665673256,
0.005176500882953405,
0.004805423319339752,
0.004819149617105722,
0.02008271962404251,
-0.0027951886877417564,
0.016088217496871948,
0.03590907156467438,
-0.021198423579335213,
0.00047217123210430145,
0.013271022588014603,
-0.003971284255385399,
-0.008078892715275288,
-0.01265101507306099,
0.00976600032299757,
0.017912721261382103,
-0.021988265216350555,
0.00040046777576208115,
-0.01154525950551033,
0.009774898178875446,
0.011886539869010448,
0.00336388498544693,
0.007212586235255003,
0.004882947541773319,
-0.008938120678067207,
-0.0026217231061309576,
0.0015904828906059265,
-0.009041907265782356,
-0.012780996970832348,
0.013025806285440922,
0.015266702510416508,
-0.0029965704306960106,
0.0076242126524448395,
-0.0074677858501672745,
-0.003508083987981081,
0.004955773241817951,
-0.021145397797226906,
-0.010673819109797478,
0.008843280375003815,
0.02759474515914917,
-0.010496318340301514,
0.009743212722241879,
-0.013055063784122467,
0.006057661026716232,
-0.011627542786300182,
-0.018695633858442307,
-0.015318885445594788,
0.014689718373119831,
-0.02118910290300846,
-0.004188321530818939,
0.004380308091640472,
-0.0012690769508481026,
0.008557287976145744,
-0.006122889928519726,
-0.0077577694319188595,
0.006342268083244562,
-0.005539743695408106,
0.016708213835954666,
-0.03188370168209076,
0.007504153531044722,
0.0014662658795714378,
0.03661206364631653,
0.003638105932623148,
0.020496724173426628,
-0.0033173426054418087,
0.004874556791037321,
0.0016033246647566557,
0.003986718133091927,
-0.00045035360381007195,
0.006674240343272686,
0.03454502671957016,
0.008055279031395912,
-0.011183726601302624,
-0.005858791060745716,
-0.006320015527307987,
0.0074724904261529446,
-0.005170118063688278,
0.0047937058843672276,
-0.08145219832658768,
0.001779478508979082,
0.0034169750288128853,
-0.016929252073168755,
0.004827041644603014,
0.008849844336509705,
0.017042124643921852,
0.00925593450665474,
-0.006026634946465492,
0.0003458429127931595,
0.001796303316950798,
0.00889077689498663,
-0.003981471061706543,
0.00038921739906072617,
0.00725015252828598,
0.00041330826934427023,
0.009176729246973991,
0.02086574025452137,
-0.0037659264635294676,
-0.018544599413871765,
-0.020455719903111458,
0.006254992447793484,
0.01614389196038246,
-0.0014408796560019255,
-0.04414661228656769,
0.007096417713910341,
-0.008153233677148819,
0.0026586996391415596,
0.011740261688828468,
-0.004982109647244215,
0.01563863828778267,
-0.012310072779655457,
0.037715762853622437,
0.0013286243192851543,
0.013963340781629086,
0.018849704414606094,
-0.005485322792083025,
-0.026865173131227493,
-0.014734853990375996,
-0.0009875984396785498,
-0.004706111270934343,
0.004295013844966888,
0.01292840763926506,
-0.001012314110994339,
0.000651978247333318,
0.015143107622861862,
-0.004021139815449715,
0.004622173495590687,
0.01555250771343708,
-0.003860113210976124,
-0.0007218560203909874,
0.004603111185133457,
0.015691515058279037,
0.013771288096904755,
-0.011797772720456123,
0.0030019679106771946,
-0.0009781522676348686,
0.011328771710395813,
-0.01497875340282917,
-0.006558631546795368,
-0.002364546060562134,
-0.003063188400119543,
-0.001344884280115366,
0.0011594928801059723,
-0.014915996231138706,
0.0007572148460894823,
0.00729020219296217,
-0.0006753155612386763,
-0.025815274566411972,
0.006294921040534973,
-0.02080044150352478,
0.004560692235827446,
-0.0022979378700256348,
-0.00806673988699913,
-0.010599719360470772,
-0.008097109384834766,
-0.013002444058656693,
-0.003486095927655697,
-0.011140638962388039,
-0.0027148807421326637,
-0.004370685666799545,
0.0030028808396309614,
-0.0015617713797837496,
0.007720908150076866,
-0.015363728627562523,
-0.02724650874733925,
0.007124972064048052,
0.022598348557949066,
0.008325798436999321,
-0.01245596818625927,
0.016376446932554245,
0.02910229004919529,
-0.001169688068330288,
0.011128595098853111,
-0.009653724730014801,
-0.004972117953002453,
-0.02147110551595688,
0.010727658867835999,
0.009728234261274338,
0.006830031052231789,
-0.021883251145482063,
-0.009633583948016167,
0.0035307996440678835,
-0.0009961721953004599,
-0.015865545719861984,
0.009678589180111885,
-0.006343909539282322,
-0.010603751987218857,
-0.016239387914538383,
0.0013438257155939937,
-0.002910517156124115,
0.00614596251398325,
-0.002469227649271488,
0.019116096198558807,
0.0030628801323473454,
-0.007325625978410244,
-0.004988283850252628,
-0.014310629107058048,
0.07367412000894547,
0.017365723848342896,
0.005136203020811081,
-0.009447787888348103,
0.01696774922311306,
-0.005170236807316542,
0.008518155664205551,
0.011961309239268303,
-0.018376067280769348,
-0.01269599236547947,
0.008591636084020138,
-0.025423914194107056,
0.014463393948972225,
-0.022244872525334358,
-0.03201192617416382,
-0.0034245082642883062,
0.004170726984739304,
-0.025757111608982086,
0.012341667897999287,
0.0015864386223256588,
0.007828294299542904,
-0.006200517527759075,
-0.012969213537871838,
0.0034292615018785,
-0.006771599408239126,
0.003608538769185543,
0.020712902769446373,
-0.009297378361225128,
-0.015350429341197014,
0.01127967331558466,
0.0050884876400232315,
0.000025355489924550056,
-0.00791231356561184,
0.01036047376692295,
0.004182747565209866,
-0.0037594367749989033,
0.0035664401948451996,
0.001276311930269003,
-0.0053673298098146915,
-0.006201125215739012,
0.0009156535379588604,
-0.011684063822031021,
0.005818006582558155,
0.007853695191442966,
-0.0093538798391819,
-0.014139162376523018,
0.01718292012810707,
-0.00829467922449112,
-0.008492227643728256,
0.000022273045033216476,
-0.003009122097864747,
-0.008104369044303894,
0.01075013354420662,
0.03890327364206314,
0.004289731848984957,
-0.04874558001756668,
0.028816910460591316,
-0.0029320968315005302,
0.026738766580820084,
-0.009499727748334408,
-0.009862585924565792,
0.0005413277540355921,
0.015653589740395546,
-0.014325505122542381,
0.015483774244785309,
-0.023681800812482834,
-0.011230121366679668,
0.00015114201232790947,
-0.005568678490817547,
-0.02999623492360115,
0.017634712159633636,
-0.010918822139501572,
-0.002773987129330635,
0.010383538901805878,
-0.033353421837091446,
-0.004397577606141567,
0.002297617495059967,
-0.004993575159460306,
0.012866910547018051,
-0.008199706673622131,
0.0069914087653160095,
-0.006908162962645292,
0.010879629291594028,
0.00948433205485344,
0.010081510990858078,
-0.018658408895134926,
-0.027323544025421143,
-0.0752255916595459,
-0.0057434579357504845,
0.0003140745684504509,
-0.003941550385206938,
-0.0046266429126262665,
0.014913377352058887,
-0.016787629574537277,
-0.005645097233355045,
0.0005672737024724483,
-0.005985631607472897,
0.008518348447978497,
0.0008507594466209412,
0.014185288920998573,
-0.013268028385937214,
0.009965295903384686,
0.02129441685974598,
-0.0006980011239647865,
-0.0037407216150313616,
0.0006368015892803669,
0.0071761407889425755,
0.01562439650297165,
0.022674057632684708,
-0.005408747121691704,
-0.0019557622727006674,
-0.00003924802877008915,
-0.08254795521497726,
-0.022271154448390007,
0.02105337753891945,
-0.007700268644839525,
-0.004801820032298565,
-0.0132024846971035,
0.03698553144931793,
-0.019788911566138268,
-0.0017687482759356499,
-0.012078702449798584,
-0.0206869188696146,
0.0008986630127765238,
-0.0016043935902416706,
-0.001455114223062992,
-0.009342631325125694,
-0.009091274812817574,
0.01645496115088463,
0.024430807679891586,
0.007322825025767088,
0.005209051072597504,
0.010543765500187874,
-0.0027799555100500584,
-0.008939027786254883,
-0.011288243345916271,
-0.008063023909926414,
-0.004048943519592285,
-0.01972372643649578,
0.01291769277304411,
-0.010393836535513401,
0.010207836516201496,
-0.012927324511110783,
0.005684062838554382,
-0.004666618071496487,
-0.011972582899034023,
0.005661573726683855,
-0.008404689840972424,
-0.004976279102265835,
-0.012714123353362083,
-0.014041172340512276,
-0.005187078379094601,
-0.005081220529973507,
-0.0000681757228448987,
0.008379711769521236,
0.009846154600381851,
0.01477868016809225,
-0.031130658462643623,
0.005773804150521755,
-0.008767144754529,
0.010173547081649303,
-0.012202421203255653,
0.003710550256073475,
-0.012534032575786114,
0.003065001219511032,
-0.0015275552868843079,
-0.008556311950087547,
-0.0015270714648067951,
-0.002893760334700346,
-0.006624550558626652,
0.03297377750277519,
0.0028173101600259542,
0.007475985214114189,
0.015631482005119324,
0.016031967476010323,
0.07206238806247711,
-0.009971410036087036,
0.01052888948470354,
-0.02940710261464119,
-0.015591263771057129,
0.005644980818033218,
-0.02313854545354843,
0.008063536137342453,
-0.0051045650616288185,
-0.013129898346960545,
0.016902390867471695,
0.0013039858313277364,
-0.002272241283208132,
0.010903812944889069,
-0.005344417877495289,
0.008038951084017754,
-0.010189944878220558,
0.008121723309159279,
-0.00156349316239357,
0.009304394014179707,
-0.012723367661237717,
0.007997866719961166,
-0.03082769177854061,
-0.009983313269913197,
0.012694031000137329,
-0.012776026502251625,
-0.009668076410889626,
0.01034749299287796,
-0.014486845582723618,
0.0340331606566906,
0.0046492647379636765,
0.012616198509931564,
0.001351232291199267,
-0.009363595396280289,
0.003553028218448162,
-0.0041875084862113,
-0.0011303068604320288,
0.008375376462936401,
-0.0023126360028982162,
0.009962479583919048,
-0.011034084483981133,
-0.019256815314292908,
-0.0023247539065778255,
-0.016601113602519035,
0.014223651960492134,
-0.018088452517986298,
0.005130080506205559,
0.01634843647480011,
0.01092157419770956,
0.009448375552892685,
-0.0027693412266671658,
0.001727525843307376,
0.01772988960146904,
0.005939642898738384,
-0.0037011674139648676,
0.003123417031019926,
-0.005843047983944416,
0.013152273371815681,
0.009664339944720268,
0.011445078998804092,
0.004463541321456432,
-0.005203226115554571,
-0.0016194479539990425,
-0.017304278910160065,
-0.0017358637414872646,
-0.031452663242816925,
0.0030073688831180334,
-0.01586485095322132,
-0.012644232250750065,
0.015525911003351212,
-0.009994939900934696,
0.011441456153988838,
0.006083158776164055,
0.0042916154488921165,
0.017735915258526802,
0.019866975024342537,
0.01986582949757576,
-0.0007996910717338324,
0.027141757309436798,
0.021990537643432617,
-0.006737365387380123,
-0.0037723651621490717,
0.012346150353550911,
0.0003733558114618063,
-0.01587657444179058,
-0.002513187937438488,
-0.0020226272754371166,
-0.014697708189487457,
0.0021411755587905645,
0.007569849491119385,
-0.00864848867058754,
0.014172360301017761,
0.010337503626942635,
0.013656272552907467,
0.0036181281320750713,
0.03208206593990326,
0.0007367730140686035,
0.0027252747677266598,
-0.0008672252297401428,
0.015239091590046883,
0.01732216216623783,
0.0055955094285309315,
0.00005646434146910906,
0.023522190749645233,
-0.020053565502166748,
0.006370130460709333,
0.013554609380662441,
0.005755183752626181,
-0.002614852972328663,
-0.009059179574251175,
0.016708679497241974,
0.004573495127260685,
0.01348534319549799,
0.0008485633879899979,
0.01135255303233862,
0.014321268536150455,
-0.0008106469176709652,
-0.0014374218881130219,
0.013486374169588089,
-0.011510193347930908,
-0.015239700675010681,
0.0023730620741844177,
0.008126579225063324,
0.022863056510686874,
-0.017796164378523827,
-0.014321795664727688,
-0.0024604061618447304,
0.028630070388317108,
0.005590867251157761,
-0.0008402045350521803,
0.025253526866436005,
-0.00226380443200469,
-0.01647871732711792,
0.00046393275260925293,
0.013467601500451565,
0.01924736052751541,
-0.007481464184820652,
-0.010635340586304665,
-0.010347619652748108,
-0.025408640503883362,
0.014993855729699135,
-0.00988294743001461,
-0.003090487327426672,
0.02617594785988331,
0.006467924453318119,
-0.011784975416958332,
0.025602038949728012,
0.01824292726814747,
0.0061889998614788055,
-0.006078255362808704,
0.0005736793391406536,
0.004257381893694401,
0.00873437151312828,
-0.0060445209965109825,
-0.004082837142050266,
0.0019593555480241776,
-0.005114915780723095,
-0.007717858999967575,
-0.01422985177487135,
0.017109807580709457,
0.0005132036749273539,
0.019150400534272194,
0.018425360321998596,
-0.008857609704136848,
0.0042856656946241856,
0.016472838819026947,
-0.01575295440852642,
-0.008624721318483353,
0.009336636401712894,
0.005985746160149574,
0.001084804069250822,
-0.0015901459846645594,
0.0000690297456458211,
0.00550516601651907,
-0.01226726546883583,
0.0035165760200470686,
-0.01495422888547182,
0.005126095376908779,
0.0019999039359390736,
0.026217300444841385,
0.001488744281232357,
-0.008097606711089611,
0.0074503980576992035,
-0.00539059191942215,
-0.024411426857113838,
-0.013540086336433887,
-0.0014596630353480577,
0.019475646317005157,
0.009685388766229153,
0.027751807123422623,
-0.0037756492383778095,
0.009114638902246952,
-0.006770901847630739,
-0.0030917185358703136,
0.005735370330512524,
0.005285806953907013,
0.016153482720255852,
-0.02161337435245514,
-0.00496700219810009,
0.019134141504764557,
0.011101952753961086,
-0.011808604933321476
] | [
-0.13386031985282898,
0.10838979482650757,
-0.1029580757021904,
-0.1826242357492447,
0.0629984438419342,
0.7539243102073669,
0.4919351637363434,
-0.19592171907424927,
0.03464579954743385,
-0.7510603070259094,
0.2814026176929474,
0.3776697516441345,
-0.3546846807003021,
0.15919962525367737,
0.24901169538497925,
0.7599755525588989,
0.04478776827454567,
0.15975609421730042,
0.08101421594619751,
-0.30346691608428955,
-0.26603177189826965,
-0.2945776581764221,
0.7028864622116089,
-0.2399819940328598,
-0.009698049165308475,
-0.05410259962081909,
0.9225181937217712,
0.22842468321323395,
0.4157533645629883,
-0.36057713627815247,
0.008262592367827892,
0.7313056588172913,
0.18965832889080048,
-0.5502302646636963,
0.02845844253897667,
0.018900278955698013,
-0.3728039562702179,
0.23717646300792694,
0.07201121747493744,
-0.2700594961643219,
-0.36744076013565063,
-0.35717061161994934,
-0.5049139261245728,
0.35722240805625916,
-0.4779472351074219,
-0.498209685087204,
-1.6830706596374512,
0.6848952770233154,
-0.2512647211551666,
0.41234689950942993,
0.09067495912313461,
0.7058654427528381,
0.4142371118068695,
-0.18507318198680878,
0.3454394042491913,
0.16086243093013763,
-0.18436363339424133,
-0.2644210755825043,
0.521190881729126,
-0.5820042490959167,
0.16418790817260742,
0.018008701503276825,
-0.04395712539553642,
0.19145487248897552,
-0.4629848897457123,
0.6752183437347412,
0.18673086166381836,
0.013396408408880234,
-0.4196048080921173,
-0.272625595331192,
0.22218498587608337,
-0.532034158706665,
-0.3037310540676117,
0.5303258895874023,
-0.05435881018638611,
-0.4338308870792389,
-0.3170732855796814,
-0.3090745508670807,
-0.02651059441268444,
0.3392428159713745,
0.033971916884183884,
0.18626035749912262,
0.404649555683136,
-0.13674229383468628,
0.16760827600955963,
-0.010457389988005161,
0.15445657074451447,
0.6649442315101624,
-0.6594597697257996,
0.22423021495342255,
-0.32740822434425354,
-0.03360915556550026,
0.31452420353889465,
0.17730188369750977,
0.09978116303682327,
0.08141092956066132,
-0.48424163460731506,
0.18079689145088196,
0.4153897762298584,
0.5558903813362122,
-0.10991161316633224,
-0.38022980093955994,
-0.12566402554512024,
0.06756908446550369,
0.0046089948154985905,
0.09568975865840912,
-0.25130173563957214,
-1.281665325164795,
-0.9126137495040894,
-0.035944633185863495,
-0.5047072768211365,
-0.04693023860454559,
-0.10642276704311371,
-0.2534330487251282,
0.029887277632951736,
0.15030772984027863,
-0.030229853466153145,
-0.6536087393760681,
-0.20461492240428925,
0.1663852334022522,
0.13197873532772064,
0.8990709185600281,
-0.18761809170246124,
0.5113558173179626,
0.2134668081998825,
-0.4660298228263855,
0.29497426748275757,
-0.039890412241220474,
-0.2931084930896759,
0.616824746131897,
0.6249704360961914,
1.0182288885116577,
-0.35596051812171936,
-0.10755673050880432,
-0.15837687253952026,
-0.028215298429131508,
0.08965224027633667,
0.1722802370786667,
0.11071266233921051,
-0.2894396483898163,
-0.3864644467830658,
-0.6750783324241638,
-0.37137264013290405,
-0.04748709499835968,
0.21906878054141998,
-0.5466766953468323,
-0.07727083563804626,
0.3755110204219818,
-0.5705021023750305,
-0.44974884390830994,
-0.050597257912158966,
-0.33434560894966125,
-0.8210319876670837,
0.27121925354003906,
0.31161022186279297,
0.29155421257019043,
-0.11872470378875732,
-0.3573087751865387,
-0.062429510056972504,
0.29795128107070923,
0.3375789523124695,
-0.1639978587627411,
-0.7204898595809937,
0.036768872290849686,
0.14148250222206116,
0.2780357897281647,
0.27911925315856934,
0.054016660898923874,
0.09633055329322815,
-0.21796873211860657,
0.0008531999192200601,
-0.21365046501159668,
0.10404996573925018,
-0.4549243152141571,
0.014613141305744648,
-0.14984898269176483,
0.08818954229354858,
-0.2724771499633789,
0.16557545959949493,
0.6537384986877441,
-0.529635488986969,
-0.4448619484901428,
-0.24497868120670319,
-0.008032348938286304,
0.13552294671535492,
0.3590823709964752,
0.8339105844497681,
0.3205929696559906,
-0.061420977115631104,
0.03325153514742851,
-0.5899425745010376,
-0.14546553790569305,
0.565040647983551,
-0.3356325328350067,
1.573513150215149,
-0.21553950011730194,
-0.510563313961029,
1.3783928155899048,
0.44365522265434265,
0.08717183768749237,
-0.28302404284477234,
-0.0169562716037035,
0.8156196475028992,
-0.27093246579170227,
-0.7079604268074036,
-0.3141043782234192,
-0.09481588006019592,
-0.2681207060813904,
-0.11406157910823822,
0.11478561162948608,
0.4109719693660736,
-0.8197665810585022,
-0.32321250438690186,
-0.6295136213302612,
0.49923285841941833,
-0.09812238067388535,
0.06622109562158585,
0.22982248663902283,
-0.39408621191978455,
0.25302618741989136,
0.3020501434803009,
-0.8070855140686035,
0.27295801043510437,
0.6506964564323425,
-0.4143444001674652,
0.7683955430984497,
0.21420958638191223,
0.22968551516532898,
0.6269943118095398,
-0.7301243543624878,
0.3158961832523346,
-0.4736582338809967,
0.6705206036567688,
-0.23666313290596008,
-0.08319073170423508,
0.06705446541309357,
0.2937845289707184,
-0.07758047431707382,
0.1187179833650589,
-0.3160250782966614,
-0.0069959089159965515,
0.8834711909294128,
-0.7618610262870789,
-0.04651639983057976,
-0.018212156370282173,
-0.6518257260322571,
0.009283708408474922,
-0.0707685574889183,
-0.4889645278453827,
-0.0006379996775649488,
0.43166759610176086,
0.31629934906959534,
0.2760857343673706,
-0.3764851987361908,
0.2807844281196594,
0.4589548110961914,
-0.17065301537513733,
-0.2578027546405792,
-0.015251762233674526,
-0.39399126172065735,
-0.40405863523483276,
-0.13768386840820312,
0.3463164269924164,
0.5402027368545532,
0.10489775240421295,
-0.23003944754600525,
-0.5912638306617737,
-0.25612711906433105,
0.7660852074623108,
0.9848418235778809,
0.7770628333091736,
0.03473052754998207,
-0.8152174353599548,
0.14537711441516876,
0.4890059232711792,
-0.26855579018592834,
0.3202449381351471,
0.7473430037498474,
-0.5908917188644409,
-0.603114902973175,
-0.23582123219966888,
0.45247793197631836,
0.9672166705131531,
-0.4410012364387512,
0.07484962791204453,
-0.06848248839378357,
-0.20142868161201477,
0.003165207104757428,
-0.9874789714813232,
-0.4044719934463501,
-0.6007676720619202,
0.5398938655853271,
-0.32012590765953064,
0.17121091485023499,
-0.21887795627117157,
0.2777944803237915,
-0.15601305663585663,
0.3072047829627991,
0.7190167307853699,
-0.045969974249601364,
0.03965025022625923,
0.2210860699415207,
-0.6796634793281555,
-0.2315531075000763,
-0.27323195338249207,
0.020393531769514084,
-0.6052114963531494,
0.3632337749004364,
-5.749267578125,
-0.14143428206443787,
-0.21297858655452728,
0.13452975451946259,
-0.10605993121862411,
-0.018906312063336372,
1.0534460544586182,
-0.2572767436504364,
0.4648841917514801,
0.012649042531847954,
0.42461591958999634,
0.6558080911636353,
0.31247708201408386,
-0.6226075291633606,
-0.0366981141269207,
0.48932793736457825,
-0.11228656023740768,
-0.7370136380195618,
0.7635568976402283,
0.010975213721394539,
0.7361353039741516,
-0.30805566906929016,
-0.4125831127166748,
0.35320764780044556,
0.008674695156514645,
-0.2051697075366974,
-0.984343945980072,
0.37795495986938477,
-0.11837274581193924,
-0.3255220949649811,
0.13148942589759827,
-0.6792201995849609,
-0.3047027885913849,
-0.06394371390342712,
0.3405023515224457,
-0.2841847240924835,
0.35787203907966614,
-0.56907719373703,
0.26716408133506775,
-0.4733467102050781,
0.34056827425956726,
0.4195423424243927,
-0.31013840436935425,
-0.06580379605293274,
0.30370980501174927,
-0.38613665103912354,
-0.19836567342281342,
0.4862494468688965,
-0.041361112147569656,
0.16054408252239227,
0.193020761013031,
-0.27802684903144836,
0.03934631124138832,
1.0788835287094116,
0.6228110790252686,
-0.2191096544265747,
-0.2744131088256836,
0.1721530705690384,
-0.24515146017074585,
0.23870795965194702,
-0.23860424757003784,
-0.33829542994499207,
-0.3355385959148407,
-0.543060302734375,
-0.07086782157421112,
-0.07711241394281387,
-0.6164340972900391,
-0.5746904611587524,
0.17175333201885223,
-0.5659617781639099,
0.02401702105998993,
-0.21185019612312317,
-0.047442831099033356,
-0.8052323460578918,
0.5334075689315796,
-0.08742610365152359,
0.5242392420768738,
-0.2540656328201294,
-0.36018210649490356,
-0.34751439094543457,
-0.45159733295440674,
-0.3571391701698303,
-0.2060537487268448,
-0.13955911993980408,
0.3371555507183075,
-0.22102582454681396,
-0.011806105263531208,
-0.21059416234493256,
-0.3134014904499054,
0.2904932498931885,
0.5334892272949219,
-0.2510616183280945,
0.13678960502147675,
0.7508676648139954,
0.0205142293125391,
0.33443382382392883,
0.5089149475097656,
0.3572985529899597,
0.3212509751319885,
0.24304519593715668,
0.7133591771125793,
0.1341867297887802,
-0.3248850703239441,
-0.8146083354949951,
0.2232557237148285,
0.4172091484069824,
-0.2806469798088074,
0.007463046349585056,
0.8651806712150574,
-0.5159122347831726,
-0.14471036195755005,
-0.10841695964336395,
-0.4308541417121887,
0.5294922590255737,
0.4723014831542969,
-0.23195767402648926,
-0.3086339831352234,
0.13091978430747986,
0.5154540538787842,
0.07606110721826553,
-0.19922572374343872,
0.47404634952545166,
-0.7931356430053711,
0.30028340220451355,
0.04687926545739174,
-0.38170677423477173,
-0.26494544744491577,
0.31745055317878723,
-0.48463472723960876,
-0.19373875856399536,
0.49542954564094543,
0.5211536288261414,
-0.7319031357765198,
-0.1299077272415161,
0.30967390537261963,
-0.16844716668128967,
-0.6165033578872681,
0.06668056547641754,
0.15105144679546356,
0.04395420476794243,
-0.1860933154821396,
-0.015294068492949009,
0.16232863068580627,
-0.1205739676952362,
0.21473781764507294,
0.04847855865955353,
0.38356831669807434,
-0.04936513677239418,
-0.41686347126960754,
0.1511663794517517,
-0.35582736134529114,
0.14566104114055634,
0.14740343391895294,
0.14565639197826385,
-0.03961830958724022,
0.4161694645881653,
0.39416858553886414,
0.018061432987451553,
0.40247029066085815,
-0.16693934798240662,
0.25639837980270386,
0.23310425877571106,
-0.509015679359436,
0.3321394920349121,
-0.08393492549657822,
-0.024142874404788017,
-0.10371454060077667,
-0.44473400712013245,
0.03558655083179474,
0.36408329010009766,
-0.18318112194538116,
-0.19673585891723633,
-0.07884429395198822,
0.04821624234318733,
0.13934741914272308,
-0.3550882041454315,
-0.565229058265686,
-0.1288914978504181,
-0.07000705599784851,
0.22428157925605774,
-0.051621150225400925,
-0.5930593013763428,
-0.27953198552131653,
0.38789814710617065,
0.5382908582687378,
0.06148979812860489,
-0.27341312170028687,
-0.26604053378105164,
-0.012776324525475502,
-0.5054783821105957,
-0.14429180324077606,
0.1585649847984314,
0.41753605008125305,
-0.2745264172554016,
-0.1616499423980713,
-0.19026249647140503,
-0.010264573618769646,
0.5210794806480408,
-0.2797635793685913,
-0.8263406753540039,
-0.2177126556634903,
0.6354138255119324,
-0.7817960381507874,
0.2141583263874054,
0.3159027695655823,
0.00667655561119318,
-0.3517138361930847,
-0.3381991982460022,
0.3839324712753296,
-0.035257529467344284,
-0.29131636023521423,
-0.11410049349069595,
0.2599392533302307,
0.6524879932403564,
-0.20124182105064392,
-0.08592668175697327,
0.31384891271591187,
-0.33417052030563354,
-0.1820111721754074,
0.22234758734703064,
0.25992223620414734,
-0.35969677567481995,
-0.14335991442203522,
-0.05753176659345627,
-0.5940974354743958,
0.18789736926555634,
0.1722641885280609,
-1.2313288450241089,
0.30078205466270447,
0.5097357630729675,
0.02326059713959694,
-0.25948527455329895,
0.3848707675933838,
0.3447660505771637,
-0.512732207775116,
-0.01844150759279728,
-0.6047881245613098,
-0.10424879193305969,
-0.11932544410228729,
0.6706740856170654,
0.0542062371969223,
0.37981316447257996,
-0.24394303560256958,
-0.08953152596950531,
0.14152471721172333,
0.004726400598883629,
0.3574365973472595,
-0.4382821023464203,
-0.7043216228485107,
0.3224427402019501,
0.26524895429611206,
0.29942411184310913,
0.17302195727825165,
0.490994930267334,
0.9881937503814697,
-0.0267668217420578,
0.020773330703377724,
-0.4441620707511902,
-0.36910635232925415,
0.4709276556968689,
-0.2721376121044159,
0.18310950696468353,
-0.11474151909351349,
0.12597505748271942,
-0.0189072135835886,
0.04024342820048332,
-0.04344871640205383,
-0.7985643148422241,
0.4944661259651184,
-0.09753704071044922,
-0.25415611267089844,
0.17627079784870148,
0.36527982354164124,
0.3836763799190521,
-0.3654724955558777,
0.23452724516391754,
-0.22734761238098145,
0.3167787790298462,
0.014473299495875835,
0.47856003046035767,
-0.23488320410251617,
-0.48817530274391174,
-0.06227738782763481,
-0.6902464032173157,
0.36617136001586914,
-0.26243460178375244,
0.36903122067451477,
-0.35566869378089905,
0.17330114543437958,
-0.5383924841880798,
-0.29075396060943604,
0.03113796003162861,
-1.1033846139907837,
0.042010348290205,
-0.33015239238739014,
-0.0041076685301959515,
0.07639757543802261,
0.00699335802346468,
-0.35331201553344727,
-0.05249306187033653,
-0.5279504656791687,
0.6217158436775208,
0.6531678438186646,
-0.4787633717060089,
0.0707225501537323,
0.15171900391578674,
0.05816637724637985,
0.1936047226190567,
-0.09839770197868347,
-0.3772953450679779,
-0.0506560243666172,
-0.22818239033222198,
0.5127151012420654,
0.14081764221191406,
0.026940880343317986,
0.5638744831085205,
-0.1666540503501892,
0.23076081275939941,
-0.13071784377098083,
0.15522238612174988,
0.15906022489070892,
0.2989082932472229,
0.5904138088226318,
-0.29053300619125366,
-0.10824113339185715,
0.5654151439666748,
0.4709321856498718,
0.021205462515354156,
0.04970650002360344,
0.6942012906074524,
0.1942763328552246,
-0.0598883293569088,
-0.22503899037837982,
0.3873850107192993,
0.5801287293434143,
0.14757226407527924,
0.21666379272937775,
-0.12645050883293152,
-0.02855939418077469,
-0.14094199240207672,
0.7669862508773804,
0.2771022319793701,
-0.3671998083591461,
-0.08326982706785202,
0.31035125255584717,
0.370483934879303,
0.3467979431152344,
0.21649731695652008,
-0.5454065203666687,
0.6802781820297241,
0.06341233849525452,
-0.27812257409095764,
-0.5396220684051514,
0.3877016007900238,
-0.38557755947113037,
0.14654205739498138,
0.546138346195221,
-0.33556389808654785,
-0.43346303701400757,
0.36741146445274353,
0.10339461266994476,
0.12771649658679962,
-0.018242377787828445,
0.5387750267982483,
-0.2779254615306854,
0.04292885586619377,
0.04978852719068527,
0.2571079134941101,
-0.041885893791913986,
-0.3714870810508728,
0.23514705896377563,
0.3425106406211853,
-0.1293518841266632,
0.3920646011829376,
0.15069496631622314,
-0.12097959965467453,
0.22733400762081146,
-0.411148339509964,
-0.0018777156947180629,
0.001693183439783752,
-0.38499704003334045,
-0.0665406733751297,
-0.22690695524215698,
-0.49644431471824646,
-0.21362468600273132,
-0.01933823712170124,
-0.08846244215965271,
0.26993635296821594,
0.35721489787101746,
-0.39209362864494324,
0.11793185025453568,
-0.7532662153244019,
-0.4234701693058014,
0.1444685161113739,
-0.37272852659225464,
-0.09613122791051865,
-0.2458820939064026,
0.607377290725708,
0.2637813091278076,
1.0288411378860474,
0.3533491790294647,
-0.04190247505903244,
0.14868387579917908,
0.6934900283813477,
-0.6061822175979614,
0.5522879362106323,
-0.3004443645477295,
-0.11529230326414108,
-0.6034373641014099,
-0.2974206805229187,
1.332226276397705,
0.6361757516860962,
-0.2108704298734665,
-0.01348019391298294,
-0.49288779497146606,
0.22669905424118042,
0.3199726343154907,
-0.6863294839859009,
0.3155847489833832,
-0.33932235836982727,
-0.009995917789638042,
-0.47235986590385437,
0.43033841252326965,
-0.16620191931724548,
-0.750098466873169,
-0.11664341390132904,
0.41122010350227356,
0.18233181536197662,
0.023937460035085678,
0.5011928677558899,
-0.1460466831922531,
0.005850983317941427,
-0.22383995354175568,
0.6824468374252319,
-0.51380854845047,
0.14325429499149323,
-0.2702973484992981,
0.347162663936615,
0.16576750576496124,
-0.24912720918655396,
0.20784470438957214,
-0.6824721097946167,
0.4049895703792572,
0.16874460875988007,
-0.24165216088294983,
0.08096568286418915,
-0.09855183959007263,
-0.8977038264274597,
-0.3263295590877533,
0.4165695011615753,
-0.08436929434537888,
-0.5534471869468689,
-0.15579715371131897,
0.14691464602947235,
0.13094274699687958,
0.28508228063583374,
0.015847954899072647,
-0.3822138011455536,
-0.33259686827659607,
-0.12135806679725647
] |
Community-acquired methicillin resistant Staphylococcus aureus (CA-MRSA) is considered an underreported entity in India. In this case report, the authors describe a thirty-five year old immunocompetent male presenting with severe respiratory distress requiring intubation. On further work up, a CT thorax showed features consistent with necrotizing pneumonia. The morphology and sensitivity pattern of the organism found in the bronchoalveolar lavage fluid and blood culture were consistent with MRSA. The patient's stay in the hospital was complicated by acute renal failure due to rhabdomyolysis with CPK levels of 9995 U/L. The patient was started on dialysis and improved there after. This case brings to light that CA-MRSA is becoming a problem in developing nations where antibiotics are frequently used empirically with little laboratory guidance. It also is a rare reporting of rhabdomyolysis due to CA-MRSA. | [
-0.010409478098154068,
0.004681513644754887,
-0.004714176524430513,
0.01435298752039671,
0.02781684696674347,
0.018028654158115387,
0.009103846736252308,
0.0171898752450943,
-0.011972535401582718,
-0.010921027511358261,
-0.001176760415546596,
0.014832708053290844,
0.0029220199212431908,
0.008805086836218834,
-0.003983828239142895,
0.015861328691244125,
-0.019688863307237625,
0.01836969703435898,
0.009809350594878197,
-0.0002847930882126093,
-0.004770610947161913,
-0.015581026673316956,
0.008604181930422783,
-0.0018352698534727097,
0.005943330470472574,
-0.010923667810857296,
-0.011847877874970436,
0.017020024359226227,
-0.03498484566807747,
0.009535805322229862,
-0.012602395378053188,
0.02082926407456398,
0.00812423974275589,
-0.008030249737203121,
0.013536075130105019,
-0.01417682133615017,
0.00046855557593517005,
0.024847181513905525,
0.01006646640598774,
-0.003916162997484207,
0.020834868773818016,
-0.007148282136768103,
0.004018788691610098,
-0.01572011038661003,
-0.005556024610996246,
0.0016159702790901065,
0.002030299510806799,
0.005251442082226276,
-0.012028387747704983,
0.007599757052958012,
-0.006838132161647081,
0.008066936396062374,
-0.0025447297375649214,
0.0040495614521205425,
-0.005715511739253998,
-0.0008635141421109438,
0.016620926558971405,
0.03722821921110153,
0.0004889252595603466,
-0.006990933790802956,
0.018345773220062256,
0.002373151946812868,
-0.006699065212160349,
-0.002216125139966607,
-0.004112754017114639,
-0.06697535514831543,
0.029243795201182365,
0.003107937518507242,
-0.009854556992650032,
0.01684894971549511,
-0.011138211004436016,
0.004717047326266766,
-0.01202685572206974,
0.0033045324962586164,
0.00545703899115324,
-0.010312898084521294,
-0.01606440357863903,
0.01390139851719141,
-0.0076513746753335,
0.006146757397800684,
0.02393282763659954,
-0.010685872286558151,
-0.016163334250450134,
0.01582273840904236,
-0.0018394789658486843,
0.005579126998782158,
-0.01999570056796074,
0.005605324171483517,
0.0030399118550121784,
-0.003317569848150015,
0.008440669625997543,
-0.013506773859262466,
-0.021037669852375984,
0.004064898006618023,
0.015855291858315468,
-0.00152766820974648,
-0.012399991974234581,
0.00009039882570505142,
-0.0220014825463295,
0.03979915753006935,
-0.012196519412100315,
0.02142952010035515,
0.017970692366361618,
-0.01142057217657566,
-0.011332820169627666,
0.003928454592823982,
-0.0021795881912112236,
0.01256585493683815,
0.037750549614429474,
0.011364889331161976,
-0.0031806593760848045,
-0.006179872900247574,
-0.0390118807554245,
0.013526317663490772,
-0.003279156982898712,
-0.0059465570375323296,
0.00856982171535492,
0.002570576034486294,
0.007072010543197393,
-0.023101620376110077,
0.003771897405385971,
-0.02367647923529148,
0.0011168934870511293,
-0.011964952573180199,
0.003031289903447032,
0.02353515848517418,
-0.032715290784835815,
-0.004945545457303524,
-0.0005944487638771534,
0.013319739140570164,
-0.004111498594284058,
-0.001722259446978569,
-0.003363463096320629,
0.03701914846897125,
0.023898020386695862,
-0.00007475330494344234,
-0.008879348635673523,
-0.014162814244627953,
-0.003415012964978814,
-0.025418056175112724,
0.005667455028742552,
0.010205354541540146,
0.0021429546177387238,
0.0059403590857982635,
0.00745649728924036,
-0.01825820654630661,
0.028057511895895004,
0.00429778266698122,
0.009355357848107815,
-0.0017387493280693889,
0.0029468685388565063,
-0.023065762594342232,
-0.01988581195473671,
-0.0015813554637134075,
-0.012723393738269806,
0.029917065054178238,
-0.00328794214874506,
-0.023936886340379715,
0.0006761284312233329,
0.019481655210256577,
0.024374596774578094,
-0.015873217955231667,
0.004646972753107548,
0.009294210001826286,
0.01777517795562744,
-0.021759435534477234,
-0.007912390865385532,
-0.006968885660171509,
0.020201127976179123,
0.005224120803177357,
0.0024056246038526297,
-0.001332289190031588,
-0.0068758949637413025,
0.005887159146368504,
0.017845621332526207,
-0.0016611211467534304,
-0.019225817173719406,
0.003715522587299347,
-0.019810063764452934,
0.0664251446723938,
0.0006704253610223532,
0.016374440863728523,
0.017847750335931778,
-0.01198097225278616,
0.008534889668226242,
-0.008160903118550777,
0.021260786801576614,
-0.0012750448659062386,
-0.02051345258951187,
0.003603499848395586,
0.03069739043712616,
-0.010687168687582016,
-0.00641385605558753,
0.0019784700125455856,
-0.015713809058070183,
0.0027676187455654144,
0.027857957407832146,
0.0047344621270895,
-0.001614398555830121,
0.004715368617326021,
0.00865867454558611,
0.020492222160100937,
0.04901935160160065,
-0.024037031456828117,
0.0015741592505946755,
0.0034055057913064957,
0.014415730722248554,
-0.016744978725910187,
-0.017147600650787354,
0.028988627716898918,
0.008877156302332878,
0.004785270430147648,
-0.005918388720601797,
-0.020739981904625893,
-0.009269768372178078,
-0.006741876248270273,
0.026963306590914726,
0.00048438459634780884,
-0.001990232616662979,
-0.011948435567319393,
-0.008515276946127415,
-0.00701847905293107,
-0.018288718536496162,
0.03441566973924637,
0.0032920334488153458,
-0.011880703270435333,
0.022425752133131027,
0.00819193385541439,
0.00818379782140255,
0.005860856268554926,
-0.0042807562276721,
-0.004481250420212746,
-0.009323937818408012,
0.011435196734964848,
0.021085739135742188,
0.010334350168704987,
0.010410530492663383,
0.007113205268979073,
0.015086636878550053,
-0.016238702461123466,
0.0108343455940485,
-0.003887281520292163,
0.004987927153706551,
-0.002794354222714901,
-0.011522851884365082,
0.004648477304726839,
0.020491061732172966,
0.020353524014353752,
0.028984112665057182,
-0.007702955510467291,
0.010172512382268906,
0.0033318749628961086,
0.002169196028262377,
0.02626677043735981,
0.0051228138618171215,
0.004959985613822937,
0.007797961588948965,
0.00977746956050396,
0.025341801345348358,
0.0004992787726223469,
0.015249349176883698,
0.004461083561182022,
0.004857633262872696,
-0.0017444305121898651,
-0.023320816457271576,
0.021041827276349068,
-0.02271149680018425,
0.001278177136555314,
0.00612606480717659,
-0.015764964744448662,
0.005392018239945173,
-0.005910429172217846,
0.009769242256879807,
-0.08183222264051437,
-0.008165313862264156,
0.017575707286596298,
-0.018132567405700684,
0.0026684384793043137,
0.02543957717716694,
0.003608529921621084,
-0.008509970270097256,
-0.014795741066336632,
0.026796823367476463,
0.011108586564660072,
0.0009682129602879286,
-0.0008870503515936434,
0.011136172339320183,
0.011594411917030811,
0.002731919288635254,
0.00344419339671731,
-0.012708425521850586,
-0.012134689837694168,
0.025941520929336548,
0.0009134304709732533,
-0.007839652709662914,
0.002361624501645565,
-0.0016028202371671796,
0.012010823003947735,
0.010501710698008537,
0.007341282907873392,
0.0077998461201786995,
0.002369535155594349,
0.010305304080247879,
0.004379673860967159,
0.005592226982116699,
-0.00476347841322422,
0.003561875782907009,
0.009834516793489456,
0.007106708362698555,
-0.027615301311016083,
-0.007499841507524252,
-0.014838112518191338,
0.014233069494366646,
-0.018003253266215324,
0.007700411602854729,
0.02177329547703266,
0.0028467720840126276,
-0.0006259740330278873,
-0.0007684985175728798,
0.032924585044384,
-0.014349797740578651,
0.011838625185191631,
-0.017593927681446075,
0.0015098829753696918,
-0.01710009202361107,
-0.014766850508749485,
0.013533815741539001,
-0.01672687754034996,
-0.005664084106683731,
-0.020023886114358902,
0.0014217090792953968,
-0.0057889120653271675,
-0.0020824826788157225,
0.003864675061777234,
0.00278137787245214,
0.014180680736899376,
0.025003422051668167,
-0.009776371531188488,
0.012459466233849525,
0.001287967897951603,
-0.018099090084433556,
-0.006221390329301357,
0.010349852964282036,
-0.0036664120852947235,
0.028741849586367607,
-0.01143638789653778,
-0.017511680722236633,
-0.0014403853565454483,
-0.003403731621801853,
-0.013518395833671093,
0.002357965800911188,
-0.023454740643501282,
-0.017443763092160225,
-0.0036342721432447433,
-0.010097188875079155,
0.010142214596271515,
0.011300068348646164,
-0.013129114173352718,
0.001975935883820057,
0.007690668571740389,
0.014452592469751835,
0.008677021600306034,
-0.012542792595922947,
0.02013688161969185,
0.01382194273173809,
0.016977766528725624,
0.01164294220507145,
-0.002087925560772419,
-0.006834918633103371,
-0.004497386049479246,
-0.023267380893230438,
0.01221646461635828,
0.006503935903310776,
-0.001325263292528689,
-0.014269261620938778,
-0.013185040093958378,
-0.006450380198657513,
0.0021998074371367693,
0.009114796295762062,
0.0033719243947416544,
0.00905897282063961,
-0.010270398110151291,
0.000866693677380681,
0.015459373593330383,
0.002743411809206009,
-0.004238680936396122,
0.007283302955329418,
0.0075614359229803085,
0.01639539934694767,
0.006345516536384821,
-0.005208007525652647,
0.072634756565094,
-0.021439068019390106,
0.008327282965183258,
-0.01850164122879505,
-0.024300621822476387,
-0.017439566552639008,
-0.017551444470882416,
0.0063860490918159485,
-0.0010852058185264468,
0.011480137705802917,
0.012010874226689339,
0.02355326898396015,
-0.009403613395988941,
-0.009367063641548157,
-0.014655238017439842,
0.004768114537000656,
-0.011680683121085167,
0.006445441860705614,
0.010299146175384521,
0.022214114665985107,
0.007599829696118832,
-0.029257791116833687,
-0.01935715414583683,
-0.0006185588426887989,
-0.008622203953564167,
-0.005057019181549549,
0.023281754925847054,
-0.013029569759964943,
-0.0013278378173708916,
0.005869508720934391,
-0.0018025070894509554,
0.019056783989071846,
-0.009842049330472946,
0.002053075237199664,
0.016997605562210083,
-0.005089201964437962,
-0.018520936369895935,
0.022980958223342896,
0.009663192555308342,
-0.005000554956495762,
0.0008228480583056808,
-0.015870051458477974,
0.02642255835235119,
0.0060221971943974495,
-0.019933996722102165,
-0.005519184283912182,
0.031970635056495667,
-0.0037904749624431133,
0.00007320829899981618,
-0.0031094239093363285,
0.005220611114054918,
0.01232608500868082,
0.016451925039291382,
-0.006897172424942255,
-0.014995358884334564,
0.010511096566915512,
0.011956680566072464,
0.0030107409693300724,
0.013959530740976334,
0.008340941742062569,
0.008269181475043297,
0.00368855195119977,
-0.04300577938556671,
-0.005619657225906849,
-0.012960768304765224,
-0.009407790377736092,
-0.013191727921366692,
0.01770072430372238,
-0.009266486391425133,
-0.0013667060993611813,
0.01891322247684002,
-0.016404107213020325,
-0.028946656733751297,
-0.02125379629433155,
-0.032061535865068436,
0.008204624056816101,
-0.007596663665026426,
-0.007239778526127338,
-0.007830889895558357,
-0.01088019274175167,
0.010168991982936859,
0.005576083902269602,
-0.006411901209503412,
-0.01209889817982912,
0.030470866709947586,
-0.024001572281122208,
-0.03037801757454872,
-0.07536345720291138,
-0.02096187323331833,
-0.00973164476454258,
-0.0033093683887273073,
-0.0033883871510624886,
0.012938135303556919,
-0.021574050188064575,
-0.012452000752091408,
-0.0030756639316678047,
-0.005108965095132589,
-0.013330761343240738,
0.00268124183639884,
0.010266082361340523,
-0.002851362805813551,
0.011480974033474922,
-0.012539159506559372,
0.013331619091331959,
-0.005019589327275753,
-0.04124932736158371,
0.028249744325876236,
-0.011454976163804531,
-0.009151274338364601,
0.003681732341647148,
0.00586154218763113,
-0.012956105172634125,
-0.08151638507843018,
0.004081200808286667,
-0.00310068903490901,
0.009234447032213211,
-0.015294118784368038,
0.009793521836400032,
0.03354055806994438,
-0.010851038619875908,
-0.003470765193924308,
-0.01285385712981224,
-0.008679330348968506,
-0.0022516311146318913,
0.0066496143117547035,
-0.006397062446922064,
0.026947662234306335,
-0.007205754052847624,
0.02566680498421192,
-0.013760572299361229,
-0.01842258870601654,
-0.010335749015212059,
-0.009373846463859081,
0.042758695781230927,
-0.002282228320837021,
0.004013183992356062,
-0.0027414478827267885,
0.006860435474663973,
-0.0010453341528773308,
0.009517301805317402,
0.0009189024567604065,
-0.0024321535602211952,
-0.012544985860586166,
0.0030526428017765284,
-0.02265000343322754,
-0.0039763664826750755,
-0.008252061903476715,
-0.01495707780122757,
-0.00921277329325676,
-0.01157099287956953,
-0.005907354410737753,
-0.0017753224819898605,
-0.0034428532235324383,
0.014245198108255863,
-0.003785687033087015,
-0.015278682112693787,
0.006379027385264635,
0.0002776710316538811,
0.007333825342357159,
-0.01337754912674427,
0.0022184487897902727,
0.000017348676919937134,
0.00020445487461984158,
0.00009376555681228638,
0.009194917045533657,
0.009114979766309261,
0.02377615123987198,
-0.003962458111345768,
-0.004879056941717863,
0.0023381137289106846,
0.01663878746330738,
-0.002558039501309395,
-0.00598160782828927,
0.00032121501863002777,
0.009102297946810722,
0.07175788283348083,
-0.009064393118023872,
0.01388622261583805,
0.015504896640777588,
0.00609927112236619,
0.003773030126467347,
-0.016793206334114075,
0.004921107552945614,
-0.011829808354377747,
0.009381568990647793,
0.01408066414296627,
-0.0014934451319277287,
0.02584962174296379,
0.007998867891728878,
0.02048671618103981,
0.007437859661877155,
-0.019880332052707672,
-0.016143551096320152,
-0.03261527791619301,
-0.005505683831870556,
-0.02116810716688633,
0.006706870626658201,
-0.014547398313879967,
0.024843018501996994,
0.015067342668771744,
0.0012748755980283022,
-0.005324945785105228,
0.011840308085083961,
-0.024680353701114655,
0.02373671904206276,
-0.0002605235204100609,
0.01022257748991251,
0.004443836864084005,
0.006144064944237471,
0.0005438465159386396,
-0.00045446306467056274,
0.003947213292121887,
0.012034517712891102,
-0.007641715928912163,
-0.015927279368042946,
-0.003939036279916763,
0.00849253498017788,
0.0012515659909695387,
-0.005398933310061693,
0.0365845263004303,
-0.026980925351381302,
-0.01920061744749546,
-0.02394871786236763,
0.01189824752509594,
0.019579201936721802,
-0.007278814446181059,
0.019756048917770386,
-0.0033129604998975992,
0.00308881513774395,
-0.015169146470725536,
-0.004618024453520775,
-0.012947823852300644,
0.0007876636227592826,
0.0074040587060153484,
-0.015988444909453392,
-0.01062093023210764,
0.0009251657174900174,
0.0029789460822939873,
-0.021586157381534576,
0.019105954095721245,
0.010625084862112999,
0.00945359654724598,
-0.013609198853373528,
-0.00858008861541748,
0.013543723151087761,
0.0008837776258587837,
-0.009764797985553741,
0.00616175401955843,
-0.013103267177939415,
0.009140294045209885,
0.01217818446457386,
0.0001956326887011528,
0.0012705158442258835,
0.006890830118209124,
0.004444972611963749,
-0.0021492617670446634,
0.0023117391392588615,
-0.0021127050276845694,
0.001955991145223379,
0.008468769490718842,
-0.0026533855125308037,
0.0008672410622239113,
-0.008254037238657475,
0.0022150278091430664,
-0.00039995525730773807,
0.002978755161166191,
0.024845564737915993,
0.008350461721420288,
0.026892108842730522,
0.009598497301340103,
0.034507136791944504,
0.0011576127726584673,
0.00783875584602356,
-0.008165734820067883,
0.012155930511653423,
0.021108532324433327,
0.0238942913711071,
-0.002830434823408723,
0.006288984790444374,
0.011161193251609802,
-0.0016207045409828424,
-0.020814500749111176,
0.044913023710250854,
-0.023228175938129425,
-0.03338497132062912,
0.00011470075696706772,
-0.0004211394116282463,
-0.007168611045926809,
-0.004401808138936758,
-0.008331350982189178,
-0.006269414909183979,
-0.0011804962996393442,
-0.015193276107311249,
0.028703276067972183,
-0.011354392394423485,
-0.014157654717564583,
-0.031217455863952637,
-0.011329508386552334,
0.015873070806264877,
0.006486600264906883,
-0.001295444555580616,
-0.0019804288167506456,
-0.009945644065737724,
0.004440951626747847,
-0.004811006598174572,
0.012128544971346855,
0.0037281098775565624,
-0.002674950286746025,
-0.0070716822519898415,
-0.013623218983411789,
-0.005168242380023003,
0.0020817872136831284,
0.0066871680319309235,
0.008701137267053127,
-0.0027079135179519653,
0.0007568225264549255,
-0.017406895756721497,
0.013312258757650852,
0.020486468449234962,
0.007997650653123856,
0.0004500702489167452,
0.00486050033941865,
0.020819395780563354,
0.017819702625274658,
-0.004763443022966385,
0.009619852527976036,
0.0043087005615234375,
0.016001001000404358,
-0.005472139921039343,
0.009638438001275063,
0.011137891560792923,
-0.010514108464121819,
-0.004165010526776314,
-0.0014353409642353654,
0.001622633310034871,
-0.024663101881742477,
-0.004506557248532772,
-0.0018631676211953163,
-0.013721754774451256,
-0.014025094918906689,
0.023758765310049057,
0.006202474236488342,
0.012647897005081177,
-0.025054555386304855,
0.0014725786168128252,
-0.00013053161092102528,
0.005606978666037321,
-0.005444422364234924,
-0.003338482230901718,
-0.020827993750572205,
-0.009485173970460892,
-0.004747504834085703,
-0.01645546406507492,
-0.0189468152821064,
0.010647004470229149,
-0.016897255554795265,
-0.018171563744544983,
0.0005501722916960716,
-0.011237112805247307,
-0.012455274350941181,
0.008528750389814377,
-0.017090994864702225,
0.004823373164981604,
0.0060658082365989685,
-0.0009512477554380894,
-0.02093973010778427,
-0.00910433940589428,
0.005954962223768234,
-0.007240443490445614,
0.01770693250000477,
0.018310818821191788,
-0.012214871123433113,
-0.007208442781120539,
-0.011837146244943142,
-0.004507293924689293,
0.015572642907500267,
-0.02139018289744854
] | [
0.11658098548650742,
0.09859266132116318,
0.09100199490785599,
-0.49357306957244873,
0.27697089314460754,
0.06131086125969887,
0.3781168460845947,
0.022309262305498123,
0.032313622534275055,
0.1563103199005127,
-0.17033235728740692,
-0.04308364540338516,
-0.1279529184103012,
0.5369216203689575,
0.11889263987541199,
0.6030535101890564,
0.8023037314414978,
0.46037980914115906,
-0.1896292120218277,
-0.3607662320137024,
-0.5191684365272522,
-0.6203615665435791,
0.5504804253578186,
0.44316473603248596,
-0.062268275767564774,
0.21787241101264954,
0.47903403639793396,
-0.08218730241060257,
-0.10211839526891708,
-0.668958306312561,
0.41533777117729187,
0.2277497500181198,
0.4879170060157776,
-0.5079038143157959,
0.08548033982515335,
-0.0591374896466732,
-0.21221573650836945,
-0.37635159492492676,
-0.4324643015861511,
-0.611016035079956,
-0.46682462096214294,
-0.500388503074646,
0.18128325045108795,
0.5475042462348938,
-0.24755504727363586,
-0.049079328775405884,
-0.7430244088172913,
0.8054924607276917,
-0.4904996156692505,
0.26110124588012695,
0.41937455534935,
-0.22930622100830078,
0.5267907381057739,
-0.161350816488266,
0.07810045778751373,
-0.02810700051486492,
-0.9303839206695557,
-0.3314400613307953,
0.2561648488044739,
-0.6391370892524719,
0.3227042257785797,
0.08685649931430817,
-0.03631077706813812,
-0.11888595670461655,
-0.33877915143966675,
0.5821221470832825,
-0.02860070951282978,
-0.14170671999454498,
-0.09888133406639099,
0.22124449908733368,
0.311585396528244,
-0.5100569725036621,
-0.1685711145401001,
0.259060800075531,
-0.32845231890678406,
0.039500486105680466,
-0.4732881188392639,
-0.4576758146286011,
0.2975581884384155,
-0.15888288617134094,
-0.13814471662044525,
-0.06939461827278137,
0.14036737382411957,
0.16515178978443146,
0.4118652641773224,
0.22956061363220215,
-0.06484342366456985,
0.4582270383834839,
-0.10331974923610687,
0.4746624529361725,
-0.07813790440559387,
0.33736681938171387,
0.5492683053016663,
0.41195714473724365,
-0.18423566222190857,
0.19446715712547302,
0.09270143508911133,
-0.1660214364528656,
0.3097677528858185,
-0.4675060510635376,
-0.6211122274398804,
0.12068590521812439,
-0.22685188055038452,
-0.039396535605192184,
-0.13447074592113495,
0.2880634665489197,
-0.6114984154701233,
0.04149363189935684,
-0.5795577764511108,
0.03895937278866768,
-0.24495723843574524,
0.3618195354938507,
-0.27787482738494873,
-0.2224305272102356,
-0.1457415223121643,
-0.10822217166423798,
0.18529359996318817,
-0.31853699684143066,
-0.03485453128814697,
-0.27758124470710754,
-0.3182953894138336,
0.6618798971176147,
-0.5327301025390625,
0.5648669600486755,
0.1581324338912964,
0.28135499358177185,
0.19553403556346893,
0.12621867656707764,
-0.249759241938591,
0.726437509059906,
0.29181402921676636,
0.634069561958313,
0.013805042020976543,
0.09834349155426025,
-0.26223447918891907,
0.09652387350797653,
0.10729353874921799,
0.09839310497045517,
0.41661980748176575,
0.017005758360028267,
-0.6523212194442749,
-0.5649433732032776,
-0.3677864670753479,
0.5337791442871094,
-0.3099290728569031,
0.13894760608673096,
-0.07323971390724182,
0.3556549549102783,
-0.06105886027216911,
-0.2201322466135025,
0.1992606222629547,
0.03823845461010933,
-0.6883257627487183,
-0.25673675537109375,
0.04396650567650795,
0.3674875795841217,
-0.04918917641043663,
-0.5053945779800415,
0.14381420612335205,
0.2595922648906708,
0.24585849046707153,
0.3611898720264435,
-0.44335854053497314,
0.026768941432237625,
0.4388047158718109,
-0.28680938482284546,
-0.16195397078990936,
0.31280505657196045,
0.11347068101167679,
0.10137881338596344,
-0.3241751492023468,
-0.49486154317855835,
-0.3051648437976837,
-0.9951567649841309,
-0.015344241634011269,
0.03207436949014664,
-0.07442481070756912,
-0.3656163513660431,
0.2527743875980377,
0.26470261812210083,
-0.5805787444114685,
0.47447821497917175,
-0.13939493894577026,
-0.26495739817619324,
0.1736396700143814,
0.12469950318336487,
0.3782080411911011,
0.10392149537801743,
0.06388820707798004,
-0.014053571037948132,
-0.2879704236984253,
-0.4731544554233551,
0.4012657403945923,
-0.5082557797431946,
1.1093707084655762,
-0.35877344012260437,
-0.025059571489691734,
1.4044008255004883,
0.5630526542663574,
-0.26263341307640076,
-0.024607250466942787,
0.7977162003517151,
0.5887812376022339,
-0.5408486127853394,
-1.0888874530792236,
0.17127183079719543,
0.10054770857095718,
-0.05406593903899193,
0.5188721418380737,
-0.023241475224494934,
0.4551449716091156,
-0.10797856748104095,
0.21325130760669708,
-0.45412272214889526,
0.5103211998939514,
0.12258876115083694,
0.08551564067602158,
0.12482091039419174,
0.41191375255584717,
-0.2940514385700226,
0.4457736313343048,
-0.8300541043281555,
0.31625014543533325,
0.8543859124183655,
-0.34308719635009766,
0.6723946928977966,
0.5384453535079956,
0.08275934308767319,
0.8827465176582336,
-0.2766411006450653,
0.3963119685649872,
-0.23626427352428436,
0.16141435503959656,
-0.4616265892982483,
-0.08177769184112549,
0.08452341705560684,
-0.16373388469219208,
-0.4470500946044922,
-0.10864552855491638,
0.1405414342880249,
-0.0223760437220335,
0.15224748849868774,
-0.14587721228599548,
0.0660858079791069,
0.06930525600910187,
-0.5859242081642151,
-0.4966587424278259,
0.13010573387145996,
-0.38592585921287537,
0.3072584569454193,
0.32837533950805664,
0.5012286305427551,
0.13749508559703827,
-0.010019447654485703,
0.32956942915916443,
0.13351722061634064,
-0.2578571140766144,
-0.47687801718711853,
0.09826575219631195,
-0.42163804173469543,
-0.03048507682979107,
0.5689838528633118,
-0.05007437244057655,
0.28944194316864014,
0.25858327746391296,
-0.29870858788490295,
-0.2840864956378937,
-0.6080783009529114,
0.738326370716095,
0.31774041056632996,
0.29408037662506104,
0.07202626019716263,
-0.5424789190292358,
0.1871667504310608,
0.05617848038673401,
-0.25374725461006165,
0.034341100603342056,
0.9775545001029968,
-0.4221499562263489,
-0.14168138802051544,
-0.6009493470191956,
0.07297695428133011,
0.38204461336135864,
-0.7157934308052063,
0.17057999968528748,
-0.1767137050628662,
-0.2888191044330597,
-0.4641106128692627,
-0.6319255232810974,
-0.23657213151454926,
-0.04911183938384056,
0.3198974132537842,
0.1365366280078888,
0.21642856299877167,
0.06837152689695358,
-0.31179651618003845,
0.036865416914224625,
0.48667576909065247,
0.6131769418716431,
-0.23652005195617676,
-0.3285495340824127,
0.2914506793022156,
-0.5033198595046997,
0.16416925191879272,
-0.1598081737756729,
-0.06648675352334976,
-0.010345462709665298,
-0.21063214540481567,
-6.094430446624756,
-0.060981377959251404,
-0.3294505774974823,
0.18661946058273315,
-0.020845085382461548,
0.05457957461476326,
1.085205316543579,
-0.09182167798280716,
0.14702999591827393,
0.48803260922431946,
0.4877089858055115,
0.694616436958313,
0.521658182144165,
-0.12626422941684723,
-0.31250637769699097,
0.09103292971849442,
-0.34100767970085144,
-0.30601227283477783,
-0.026203395798802376,
0.038574639707803726,
-0.01654023490846157,
0.17082485556602478,
-0.11154947429895401,
0.3476121127605438,
0.033554889261722565,
0.16516205668449402,
-0.9948211908340454,
0.6861579418182373,
-0.16292577981948853,
-0.38565343618392944,
0.24394716322422028,
-0.3999458849430084,
0.27449285984039307,
-0.10493569076061249,
-0.29689478874206543,
0.16224583983421326,
0.09542451053857803,
0.03467453643679619,
-0.4430426359176636,
-0.32718878984451294,
-0.08295673131942749,
-0.4086214601993561,
-0.03798362985253334,
-0.014699316583573818,
0.01582575961947441,
-0.15727753937244415,
0.07699558138847351,
0.21808122098445892,
-0.024539155885577202,
1.0187565088272095,
-0.03620392084121704,
-0.06323394924402237,
0.49560582637786865,
0.8523909449577332,
0.4064154028892517,
0.1882951855659485,
0.03563731908798218,
0.12313532084226608,
-0.0022416734136641026,
0.14873729646205902,
-0.29516366124153137,
-0.03610540181398392,
-0.2981293797492981,
-0.8040170073509216,
0.16798192262649536,
0.3376273512840271,
-0.6874690651893616,
-0.29579275846481323,
0.05993743985891342,
-0.09091304242610931,
-0.5459141135215759,
0.047325048595666885,
0.020992569625377655,
-0.6791979074478149,
0.32866790890693665,
-0.8218835592269897,
0.4882804751396179,
0.12903083860874176,
-0.04095401614904404,
0.07591783255338669,
0.23304308950901031,
-0.06034928187727928,
-0.04333968833088875,
-0.12373501062393188,
-0.021781735122203827,
-0.45363032817840576,
0.42086151242256165,
-0.20053398609161377,
0.20016278326511383,
0.048540711402893066,
0.2936623692512512,
0.3491702377796173,
-0.4151357114315033,
0.17203599214553833,
0.3564907908439636,
0.6115570068359375,
-0.053691331297159195,
0.7399826645851135,
0.3921671211719513,
0.10281245410442352,
0.7363079786300659,
-0.2103797197341919,
-0.3643960654735565,
-0.5739130973815918,
0.027708005160093307,
-0.2843227684497833,
-0.24692697823047638,
-0.18837806582450867,
0.5744174122810364,
-0.6702454686164856,
0.07478418201208115,
-0.028844691812992096,
-0.8042202591896057,
-0.25617697834968567,
0.5668331384658813,
-0.06119609251618385,
0.17417579889297485,
0.15513616800308228,
0.32587140798568726,
0.12427308410406113,
0.4760681688785553,
0.43675994873046875,
-0.1969277560710907,
0.5069937705993652,
0.2309625893831253,
-0.4755002558231354,
0.33879244327545166,
0.6456423401832581,
-0.6922109723091125,
-0.33505380153656006,
-0.16457919776439667,
0.10163456946611404,
-0.13456019759178162,
-0.2059003710746765,
0.3063811957836151,
0.14180169999599457,
-0.5411787629127502,
-0.11244089156389236,
-0.0016487486427649856,
0.24858935177326202,
0.009046845138072968,
-0.3206976354122162,
-0.3682825565338135,
0.23653434216976166,
0.33950161933898926,
-0.1706404685974121,
-0.1377502679824829,
0.1791495531797409,
-0.08421731740236282,
-0.3139425218105316,
-0.1842987835407257,
-0.22558563947677612,
0.5268338918685913,
0.4350445866584778,
-0.585060179233551,
0.24387070536613464,
0.5351546406745911,
0.29583069682121277,
-0.3068317472934723,
-0.4856402575969696,
0.018879398703575134,
-0.19933055341243744,
-1.0973988771438599,
-0.06366550177335739,
0.23152576386928558,
-0.33529791235923767,
-0.053463466465473175,
-0.7142495512962341,
0.10337305068969727,
0.29328474402427673,
-0.03821548819541931,
-0.07632909715175629,
-0.43519264459609985,
0.0005708125536330044,
0.028452539816498756,
0.14709004759788513,
-0.44106969237327576,
-0.001790338777936995,
0.05159140005707741,
0.4299573600292206,
0.44679126143455505,
0.007394719403237104,
-0.13457919657230377,
0.2813379764556885,
0.7417669296264648,
0.4523119628429413,
0.0751592293381691,
-0.3497689962387085,
0.1047159731388092,
0.1906798630952835,
0.31284764409065247,
-0.039265964180231094,
0.5135136842727661,
-0.01732226088643074,
0.13250310719013214,
-0.38050177693367004,
0.24493658542633057,
-0.0169311985373497,
-0.15279236435890198,
-0.3783247470855713,
-0.0015665412647649646,
0.22223329544067383,
0.15711070597171783,
0.3868407607078552,
0.2768184244632721,
-0.40833014249801636,
0.0069449529983103275,
-0.29308655858039856,
-0.3673483431339264,
-0.11830581724643707,
0.08201063424348831,
-0.4900228679180145,
0.5176659822463989,
0.4583611488342285,
-0.22430235147476196,
0.09340141713619232,
-0.23164252936840057,
-0.5027669668197632,
0.11028744280338287,
0.24934861063957214,
0.08106153458356857,
0.3233017027378082,
0.16821502149105072,
-0.11393596976995468,
-0.6080402731895447,
0.7161334156990051,
0.2897450029850006,
-0.6747329235076904,
-0.27424511313438416,
0.25574466586112976,
-0.2832332253456116,
-0.10784558951854706,
0.49129757285118103,
0.0817696824669838,
-0.568370521068573,
-0.09863866865634918,
0.16882260143756866,
0.05764920264482498,
-0.012085888534784317,
0.5454006195068359,
0.1991097629070282,
0.4528625011444092,
-0.10269390791654587,
-0.6253345608711243,
-0.02700832299888134,
0.38275012373924255,
0.16420578956604004,
0.03763735666871071,
-0.24765945971012115,
0.3106885254383087,
0.3377254903316498,
-0.031957585364580154,
0.4213768541812897,
-0.1598680317401886,
0.539840579032898,
-0.47372105717658997,
-0.1436329185962677,
-0.4395391345024109,
0.04137350991368294,
0.1381712108850479,
-0.5174151659011841,
-0.30072900652885437,
0.27497541904449463,
-0.06469707190990448,
-0.155091792345047,
-0.06385795772075653,
-0.30149492621421814,
-0.7983227372169495,
-0.10367514938116074,
-0.5106577277183533,
0.08656640350818634,
-0.31848934292793274,
0.9503422975540161,
0.6931312084197998,
0.2742527425289154,
0.24180938303470612,
-0.7214140295982361,
-0.6922948360443115,
-0.2510392963886261,
0.3918038606643677,
-0.2063596546649933,
-0.33705589175224304,
-0.695658802986145,
-0.11556638032197952,
-0.08601045608520508,
-0.3255658447742462,
0.19028528034687042,
-0.31310030817985535,
-0.1623842716217041,
-0.3518412411212921,
-0.2101508229970932,
0.29274454712867737,
-0.3766738176345825,
-0.31664523482322693,
-0.0393991619348526,
-0.2591780126094818,
0.11331215500831604,
0.6223383545875549,
-0.023646056652069092,
-0.21167050302028656,
-0.22110041975975037,
0.7237519025802612,
0.7786307334899902,
-0.42950373888015747,
0.12272590398788452,
0.4384455382823944,
-0.06995735317468643,
0.1258830726146698,
0.12335202097892761,
-0.06266829371452332,
0.2246428281068802,
-0.15607699751853943,
0.2224409431219101,
0.4388215243816376,
-0.32002198696136475,
0.22177445888519287,
-0.376634806394577,
-0.5654481649398804,
0.21617983281612396,
0.06015012413263321,
0.33097344636917114,
0.7411888837814331,
0.5343381762504578,
0.24921855330467224,
0.06713756173849106,
0.6587622165679932,
-0.28115910291671753,
-0.12812617421150208,
0.2013435810804367,
0.738840639591217,
0.48099565505981445,
0.5447593331336975,
-0.35587769746780396,
0.2401677966117859,
-0.2573646008968353,
0.29395708441734314,
-0.10276290029287338,
-0.4235609769821167,
-0.3043535649776459,
0.14978204667568207,
0.5435054898262024,
-0.024832788854837418,
0.06151880696415901,
-0.07278428226709366,
-0.14161480963230133,
0.3901905417442322,
0.4116724729537964,
-0.004873484373092651,
-0.044583410024642944,
0.02965795062482357,
-0.01046766061335802,
-0.26162317395210266,
0.10762010514736176,
-0.01029369980096817,
-0.5372664928436279,
0.49420905113220215,
-0.07014451920986176,
-0.12268181145191193,
-0.3862251341342926,
0.08743389695882797,
-0.3315931558609009,
-0.12976855039596558,
-0.17216408252716064,
0.3720552921295166,
-0.024687593802809715,
-0.39665570855140686,
0.00188368558883667,
-0.2229933887720108,
0.11853820830583572,
0.04167305305600166,
0.06285837292671204,
-0.647668182849884,
-0.4871758818626404,
0.22057893872261047,
0.7194241285324097,
-0.17825137078762054,
0.08292458206415176,
0.324227511882782,
0.14977511763572693,
0.38598859310150146,
-0.7569037675857544,
-0.2016175389289856,
0.024087131023406982,
-0.25515615940093994,
-0.17727132141590118,
-0.09543519467115402,
-0.5107858777046204,
0.26252472400665283,
-0.29086580872535706,
-0.2766976058483124,
-0.33590593934059143,
-0.2288883775472641,
0.031027019023895264,
0.324503093957901,
0.04152932018041611,
-0.10875635594129562,
0.20002871751785278,
-0.10649257153272629,
0.2668217718601227,
0.5285284519195557,
-0.4183906018733978,
-0.03596070036292076,
-0.08473429083824158,
-0.09960874170064926,
-0.4459927976131439,
0.3845324218273163,
-0.40971359610557556,
-0.03018670529127121,
-0.39008018374443054,
0.03444258123636246,
0.3290216624736786,
0.47979605197906494,
-0.37520891427993774,
0.0556572861969471,
0.2022061049938202,
0.3362501859664917,
0.2983284294605255,
-0.3917887210845947,
-0.15564320981502533,
-0.6561952829360962,
-0.42210653424263,
-0.2870123088359833,
0.5971990823745728,
-0.21382851898670197,
0.07700347900390625,
0.20430141687393188,
0.576200008392334,
0.3572259545326233,
-0.304512083530426,
0.26291224360466003,
-0.1526721864938736,
-0.10620412230491638,
-0.2909596562385559,
0.5363729000091553,
-0.37203845381736755,
-0.1122153103351593,
-0.10855413973331451,
0.1950789839029312,
0.04895298555493355,
-0.22781266272068024,
0.3027094304561615,
-0.6335363388061523,
0.03933790698647499,
-0.4211046099662781,
0.07065097242593765,
0.4754579961299896,
-0.20559416711330414,
-0.15386135876178741,
-0.8687785267829895,
-0.0067682727240026,
-0.15355221927165985,
-0.7980253100395203,
-0.0036924807354807854,
0.02360551804304123,
-0.28797465562820435,
-0.3796408176422119,
-0.10626720637083054,
-0.33381226658821106,
-0.20249469578266144,
-0.20271824300289154
] |
The envelope of HSV-1 contains a number of glycoproteins, four of which are essential for virus entry. Virus particles lacking gB, gD, gH or gL are entry-defective, although these viruses retain the ability to bind to the plasma membrane via the remaining glycoproteins. Soluble forms of gD have been shown to trigger the nuclear translocation of the NF-κB transcriptional complex in addition to stimulating the production of Type I interferon. By taking advantage of the entry-defective phenotype of glycoprotein-deficient HSV-1 virus particles, the results presented here show that binding of virions to cellular receptors on the plasma membrane is sufficient to stimulate a change in cellular gene expression. Preliminary microarray studies, validated by quantitative real-time PCR, identified the differential expression of cellular genes associated with the NF-κB, PI3K/Akt, Jak/Stat and related Jak/Src pathways by virions lacking gB or gH but not gD. Gene induction occurred at a few particles per cell, corresponding to physiological conditions during primary infection. Reporter assay studies determined that NF-κB transcriptional activity is stimulated within an hour of HSV-1 binding, peaks between two and three hours post-binding and declines to background levels by five hours after induction. The immediate, transient nature of these signalling events suggests that HSV-1 glycoproteins, particularly gD, may alter the cellular environment pre-entry so as to condition the cell for viral replication. | [
-0.016313474625349045,
0.006467537488788366,
-0.0019362022867426276,
0.021071795374155045,
0.006110272370278835,
0.00994015857577324,
0.00949921179562807,
-0.005587173625826836,
-0.010089285671710968,
-0.014864575117826462,
-0.0084834024310112,
0.00849086046218872,
-0.014833488501608372,
0.008478356525301933,
-0.01787368208169937,
0.005813179071992636,
-0.0079865837469697,
-0.007156753912568092,
0.009032702073454857,
0.007803440093994141,
0.024462800472974777,
-0.00551400613039732,
0.010753007605671883,
-0.027169251814484596,
0.004098859615623951,
-0.016426675021648407,
0.013300767168402672,
-0.002840012311935425,
-0.008397616446018219,
0.006766126491129398,
0.0177508182823658,
-0.00865649338811636,
-0.0007785479538142681,
-0.016482289880514145,
-0.01059035211801529,
0.004955419339239597,
-0.004423331003636122,
0.030195197090506554,
0.016241155564785004,
-0.003743255976587534,
0.0029966942965984344,
-0.009553099051117897,
-0.00014836317859590054,
0.01736188679933548,
-0.00789563823491335,
-0.003004008438438177,
-0.00063832983141765,
0.0038747331127524376,
-0.008548155426979065,
0.002398210112005472,
-0.00931225810199976,
-0.01631776988506317,
-0.015383411198854446,
0.026140647009015083,
-0.006088308524340391,
0.0036759269423782825,
0.01794523000717163,
-0.020545724779367447,
-0.027957670390605927,
0.02482973225414753,
-0.005683669820427895,
0.01903398334980011,
0.009489293210208416,
0.02515655755996704,
0.012279558926820755,
-0.0673297718167305,
0.010813619941473007,
0.019154734909534454,
-0.004897525999695063,
-0.0013296962715685368,
-0.0008007611613720655,
0.0015698143979534507,
-0.03533712774515152,
0.004067602101713419,
-0.00984940491616726,
-0.01692279428243637,
-0.023616597056388855,
0.0337904617190361,
-0.0028426898643374443,
-0.005886259954422712,
0.0010449227411299944,
0.0012989689130336046,
0.0020150395575910807,
0.010164763778448105,
0.0031414220575243235,
0.0007095108740031719,
-0.025042064487934113,
-0.009349897503852844,
-0.01784946396946907,
-0.011968031525611877,
0.01869228482246399,
0.025257248431444168,
-0.02698991447687149,
-0.004815937485545874,
-0.007990013808012009,
-0.017460206523537636,
-0.0191892571747303,
-0.027149714529514313,
-0.015335414558649063,
-0.016681592911481857,
-0.0007890085689723492,
0.002719714306294918,
0.0073392982594668865,
-0.0011288681998848915,
0.002186266705393791,
0.006833680905401707,
0.012824011966586113,
0.007341202814131975,
0.005670682527124882,
0.009439591318368912,
0.002412165980786085,
0.019289012998342514,
0.005628612358123064,
0.025214506313204765,
-0.00802741851657629,
0.0057718222960829735,
-0.011945584788918495,
-0.0010526488767936826,
0.004287151154130697,
-0.005003473721444607,
-0.026098232716321945,
-0.009205606766045094,
-0.000521030742675066,
0.0007020840421319008,
0.0012321114772930741,
-0.02479485608637333,
0.0015227310359477997,
-0.01917438395321369,
0.041494183242321014,
-0.006633342709392309,
-0.0052971490658819675,
0.009970853105187416,
-0.025032514706254005,
-0.039317790418863297,
-0.0233882125467062,
0.0124729098752141,
-0.011800219304859638,
0.016934772953391075,
0.008623262867331505,
-0.008088373579084873,
-0.003313569352030754,
0.0056201680563390255,
0.003043928649276495,
0.008457115851342678,
0.009936416521668434,
0.0036962362937629223,
0.004901256877928972,
-0.004183181095868349,
0.0037974417209625244,
-0.02243884652853012,
0.018144957721233368,
0.0036314285825937986,
0.0007323301397264004,
-0.01129783596843481,
0.005240109283477068,
0.00026185973547399044,
-0.013044316321611404,
-0.026575341820716858,
-0.004901333246380091,
0.010734697803854942,
-0.014142464846372604,
-0.027741441503167152,
0.02640431374311447,
0.008657136932015419,
-0.0032497961074113846,
0.017419088631868362,
0.01579686999320984,
-0.01540355570614338,
-0.007647138088941574,
0.007185672409832478,
0.000616079312749207,
0.004625237546861172,
0.016099534928798676,
0.008106686174869537,
0.0014111925847828388,
-0.011528762057423592,
0.032574087381362915,
0.00601349538192153,
-0.01081455685198307,
0.06719206273555756,
0.00839904509484768,
0.009185410104691982,
0.004011010751128197,
-0.0037882723845541477,
0.0072955903597176075,
-0.006313789170235395,
-0.03567304462194443,
-0.009491357952356339,
-0.015269283205270767,
-0.009938333183526993,
-0.007720922585576773,
-0.0022322554141283035,
0.010189566761255264,
0.017133662477135658,
-0.008782437071204185,
0.0028924797661602497,
-0.0016704844310879707,
-0.005669720470905304,
0.016368074342608452,
0.013913314789533615,
0.03316514939069748,
-0.017590709030628204,
0.0023489673621952534,
-0.00680913683027029,
-0.017174281179904938,
0.017548253759741783,
0.013278260827064514,
0.012301640585064888,
0.004675830714404583,
-0.0003122272901237011,
0.011366302147507668,
-0.013614296913146973,
-0.013472612015902996,
0.005971518345177174,
0.0012650880962610245,
0.008281189948320389,
-0.011275215074419975,
0.020534144714474678,
-0.006025909911841154,
-0.007966732606291771,
0.0037860639858990908,
-0.016496753320097923,
-0.019459452480077744,
-0.016578830778598785,
0.007534442003816366,
-0.0077159954234957695,
0.0025480766780674458,
0.008345002308487892,
-0.021814797073602676,
0.01874970644712448,
0.009993284940719604,
-0.03951617702841759,
-0.013307007029652596,
0.008646862581372261,
0.019416434690356255,
0.0008915653452277184,
0.011336071416735649,
-0.001409290824085474,
0.003595218760892749,
-0.007139149587601423,
-0.006580687593668699,
-0.01164485327899456,
-0.0005900226533412933,
-0.026088548824191093,
0.011019840836524963,
0.020137324929237366,
-0.0039044516161084175,
0.02023264206945896,
0.008919313549995422,
-0.012975125573575497,
0.009957348927855492,
0.019415603950619698,
0.0009622245561331511,
-0.03308551758527756,
-0.0003342442214488983,
0.017605002969503403,
0.038155436515808105,
0.004816247150301933,
0.023420488461852074,
-0.00033563515171408653,
-0.0008818781352601945,
0.004901374690234661,
-0.004902534186840057,
0.008187195286154747,
-0.017778150737285614,
0.00028876587748527527,
-0.0012709745205938816,
0.014354323036968708,
-0.031973280012607574,
0.02243829146027565,
0.005263823084533215,
-0.004065827466547489,
-0.00574193149805069,
-0.08168412744998932,
-0.008344657719135284,
0.019337231293320656,
0.03160522133111954,
0.0035844258964061737,
-0.021291200071573257,
0.02624371275305748,
-0.012872084975242615,
-0.004381012637168169,
-0.011201542802155018,
-0.00026803137734532356,
0.031349506229162216,
-0.008461599238216877,
0.01681707799434662,
-0.0041448939591646194,
-0.00901375338435173,
0.011472797021269798,
-0.02694619819521904,
-0.02696964144706726,
-0.00948603730648756,
-0.010839887894690037,
-0.00736493244767189,
0.008459936827421188,
0.010958842933177948,
-0.016075242310762405,
0.00838704127818346,
0.01801605522632599,
0.006932832766324282,
-0.0019402778707444668,
0.0010102919768542051,
-0.010484154336154461,
0.003012539818882942,
0.03291087597608566,
-0.013107800856232643,
0.015628041699528694,
0.002174763474613428,
0.0003651140723377466,
-0.002265456598252058,
-0.019993167370557785,
0.00040794024243950844,
-0.01649557054042816,
0.013900771737098694,
0.009728074073791504,
0.010633517056703568,
0.015191909857094288,
0.003541082376614213,
-0.0018606523517519236,
-0.004189945757389069,
0.018314536660909653,
0.016689453274011612,
-0.002051197225227952,
0.008893536403775215,
0.013151762075722218,
0.02124728262424469,
-0.011379757896065712,
0.011884290724992752,
-0.012344686314463615,
0.03582822158932686,
-0.010884663090109825,
-0.01234159804880619,
-0.005104993935674429,
0.003623416181653738,
0.014600817114114761,
-0.00571893434971571,
-0.015353883616626263,
0.022769121453166008,
0.003435565857216716,
0.03373352065682411,
-0.015030140057206154,
-0.009532652795314789,
0.0036164389457553625,
-0.008611097000539303,
0.026122400537133217,
-0.012159885838627815,
-0.023429036140441895,
-0.009377669543027878,
-0.011712078005075455,
-0.008823879063129425,
0.010822263546288013,
-0.003992874175310135,
-0.05022599548101425,
0.006505338475108147,
-0.013944009318947792,
-0.021568194031715393,
-0.01780301332473755,
0.000287212198600173,
0.004535025916993618,
0.036306723952293396,
0.013314547948539257,
-0.013811220414936543,
0.008141223341226578,
-0.009718582034111023,
-0.014124816283583641,
0.013597792014479637,
0.010739651508629322,
-0.011961213313043118,
0.014398885890841484,
0.016257090494036674,
0.02123510278761387,
0.008992508053779602,
-0.018414007499814034,
-0.0033384026028215885,
-0.016742559149861336,
0.0016367536736652255,
-0.035691868513822556,
0.014364310540258884,
-0.0054622832685709,
-0.018057379871606827,
-0.005243262276053429,
-0.006551811471581459,
-0.018250782042741776,
0.026026926934719086,
-0.00809578225016594,
0.004250281490385532,
0.011364122852683067,
0.005907310172915459,
0.0034755906090140343,
-0.0186129380017519,
0.07263527065515518,
-0.0000787143362686038,
-0.0034736215602606535,
-0.007785621099174023,
0.03740141913294792,
-0.019095923751592636,
-0.004003670997917652,
0.03585914522409439,
-0.02664441615343094,
0.006147128529846668,
0.011429320089519024,
0.0015128208324313164,
0.008782166987657547,
-0.02744418755173683,
-0.010520746931433678,
0.005459005944430828,
-0.012281509116292,
-0.03319650515913963,
0.010956211015582085,
0.006482014432549477,
0.0003967871889472008,
-0.011346768587827682,
0.0024716597981750965,
0.019329208880662918,
0.017055988311767578,
-0.046620406210422516,
0.0034112264402210712,
-0.014766263775527477,
-0.014633877202868462,
0.013674186542630196,
0.018075669184327126,
-0.029967620968818665,
-0.007081535644829273,
0.0093532744795084,
0.015527362003922462,
0.00186131801456213,
0.002035311423242092,
-0.0063840653747320175,
-0.01735042780637741,
0.0024849490728229284,
0.017180606722831726,
-0.01551958080381155,
-0.03758618235588074,
0.012984839268028736,
0.0022456198930740356,
-0.0033074631355702877,
-0.005552702117711306,
-0.006433767266571522,
-0.000605050940066576,
-0.019373983144760132,
-0.013854877091944218,
-0.006664068903774023,
0.014327950775623322,
0.03802654147148132,
0.026582611724734306,
-0.008545035496354103,
0.0028825742192566395,
-0.011331239715218544,
-0.020817836746573448,
0.017571773380041122,
-0.0024966939818114042,
-0.0026722345501184464,
0.002542935311794281,
0.004472525790333748,
0.01863291673362255,
-0.0144496513530612,
-0.009680096991360188,
0.000223993556573987,
-0.005396937020123005,
0.0003566161612980068,
0.016724448651075363,
-0.010314790531992912,
-0.017562609165906906,
0.005568510852754116,
-0.021080289036035538,
-0.01570402830839157,
0.01958710141479969,
0.01298280619084835,
-0.00251771230250597,
-0.022429363802075386,
0.012122044339776039,
0.0009633975569158792,
0.004136638715863228,
-0.019156044349074364,
-0.02774854563176632,
0.02533332258462906,
-0.023947805166244507,
-0.07492153346538544,
-0.015136897563934326,
-0.00982692651450634,
-0.006775545887649059,
0.01341002993285656,
-0.0007827087538316846,
-0.017823737114667892,
-0.01777816377580166,
-0.021221958100795746,
-0.008196192793548107,
-0.0012943861074745655,
-0.032677214592695236,
0.011640588752925396,
-0.009946510195732117,
0.0111831771209836,
-0.0008742772042751312,
-0.0014475558418780565,
-0.01513635367155075,
-0.012079006060957909,
0.01312168687582016,
-0.014151065610349178,
0.00801345705986023,
-0.02831156924366951,
0.005493183620274067,
0.0006786808371543884,
-0.08162736147642136,
-0.0020833900198340416,
0.005232810042798519,
-0.030637409538030624,
-0.012552611529827118,
-0.03216402977705002,
-0.000327651621773839,
-0.014411094598472118,
-0.011890565976500511,
-0.012572741135954857,
0.013585737906396389,
0.010093966498970985,
-0.003893357003107667,
-0.022870196029543877,
-0.020025910809636116,
-0.011010447517037392,
0.00792765337973833,
0.01879691705107689,
-0.006130568217486143,
0.023755675181746483,
-0.003198071615770459,
0.009364450350403786,
-0.01128244400024414,
0.0026723206974565983,
-0.009189055301249027,
-0.01836787536740303,
-0.005967789329588413,
0.00537618575617671,
0.017468348145484924,
0.008335646241903305,
0.003161766566336155,
-0.008632454089820385,
-0.000396170187741518,
-0.02000461332499981,
0.0006569518009200692,
-0.019994597882032394,
0.03615372255444527,
-0.017770927399396896,
0.005600114353001118,
-0.0021992686670273542,
0.0004379264428280294,
-0.00489804008975625,
-0.0129817184060812,
0.018337100744247437,
-0.017469890415668488,
0.005815231241285801,
0.006671410985291004,
-0.008183447644114494,
0.013643167912960052,
-0.008288062177598476,
0.004354939796030521,
-0.04608054459095001,
-0.010321812704205513,
0.02791791409254074,
0.012766890227794647,
0.00782807171344757,
-0.0029291873797774315,
0.013744574040174484,
-0.004260418936610222,
-0.001431201584637165,
-0.0055689262226223946,
0.005602480843663216,
-0.004883814603090286,
0.07217291742563248,
-0.004536776337772608,
0.0071508935652673244,
-0.01962771825492382,
-0.01505645364522934,
0.005419696681201458,
-0.015112733468413353,
0.0024572075344622135,
-0.033321183174848557,
0.0011555631645023823,
0.024693317711353302,
-0.002985613886266947,
-0.0043515730649232864,
0.013992787338793278,
-0.009699149057269096,
0.005588044412434101,
0.019917180761694908,
0.0021855109371244907,
-0.008391349576413631,
0.022638507187366486,
-0.0002662066835910082,
-0.017057882621884346,
-0.03041144832968712,
-0.00410319771617651,
0.008479728363454342,
-0.005853418260812759,
-0.019889919087290764,
0.011172267608344555,
-0.006562846712768078,
0.003137595485895872,
0.007103488780558109,
0.0021697781048715115,
0.004207698628306389,
-0.0055842893198132515,
0.0025878306478261948,
-0.009585052728652954,
-0.003781945677474141,
0.01069446001201868,
-0.013889963738620281,
0.011080114170908928,
0.009262477047741413,
-0.009800276719033718,
-0.009531106799840927,
-0.02117449790239334,
0.02360924519598484,
0.0038730637170374393,
0.03227304667234421,
0.021356696262955666,
-0.01602207124233246,
0.012382999062538147,
0.03795133903622627,
0.005898390896618366,
0.03880525380373001,
0.012507863342761993,
0.007836440578103065,
0.005786140915006399,
-0.027519715949892998,
0.0162496417760849,
-0.019173355773091316,
0.005432081874459982,
0.003515210933983326,
-0.022193310782313347,
0.008601184003055096,
-0.015097793191671371,
0.012591701932251453,
-0.017977939918637276,
0.0118810273706913,
-0.015650559216737747,
-0.009436295367777348,
0.01628139615058899,
-0.0012609383556991816,
-0.011057330295443535,
0.008404231630265713,
-0.0014931403566151857,
0.024598799645900726,
0.021090583875775337,
-0.004666930064558983,
-0.011590168811380863,
0.02929149754345417,
0.013224830850958824,
-0.008060035295784473,
-0.023722324520349503,
0.01582317426800728,
0.029706303030252457,
0.02704339101910591,
-0.010741197504103184,
0.0037445882335305214,
-0.019187401980161667,
0.00036644464125856757,
0.007203509099781513,
-0.004094259347766638,
-0.004734841175377369,
0.0034632692113518715,
0.02223510481417179,
0.0044008223339915276,
0.033434223383665085,
-0.025602858513593674,
0.007160563953220844,
0.006913149729371071,
0.0024748388677835464,
0.009061968885362148,
-0.03605467453598976,
-0.00527532584965229,
-0.00654454343020916,
0.0016632392071187496,
-0.0008508726023137569,
0.01312468945980072,
0.014773238450288773,
0.0021050318609923124,
0.016600701957941055,
-0.013439461588859558,
0.005402803421020508,
0.023278430104255676,
0.020545365288853645,
-0.0135011812672019,
0.0004474939778447151,
-0.02237716130912304,
-0.00048495130613446236,
-0.011442468501627445,
-0.008441879414021969,
-0.02897387184202671,
-0.006282346323132515,
-0.006562078837305307,
0.028444258496165276,
-0.0157212782651186,
-0.012777985073626041,
-0.008958069607615471,
0.016754150390625,
-0.015249393880367279,
0.01286221668124199,
0.009809961542487144,
0.005113472696393728,
-0.008491026237607002,
0.022112619131803513,
0.02139030396938324,
0.006093335337936878,
0.0037600654177367687,
0.005131441168487072,
-0.006426201667636633,
-0.014188604429364204,
0.0018266355618834496,
-0.014841051772236824,
0.0037706962320953608,
0.01834254339337349,
0.0068871197290718555,
0.00818639062345028,
0.01593528687953949,
0.011793826706707478,
0.004456187132745981,
0.0017280930187553167,
0.018904436379671097,
-0.009238193742930889,
-0.009448130615055561,
-0.008241042494773865,
-0.0007089667487889528,
0.007131278049200773,
0.0064724283292889595,
-0.030420077964663506,
-0.0006974778370931745,
0.0020350038539618254,
-0.0012546025682240725,
0.012705318629741669,
0.01087121106684208,
0.01457189116626978,
0.01226288452744484,
0.03142208233475685,
0.03219905123114586,
-0.009082959033548832,
-0.017819978296756744,
0.005229895003139973,
0.0213252492249012,
-0.004586063325405121,
0.004431884735822678,
-0.008737529627978802,
-0.011018780991435051,
-0.0068933237344026566,
-0.019153837114572525,
-0.008786245249211788,
0.018856529146432877,
0.019975407049059868,
0.0060545047745108604,
-0.004862511996179819,
-0.005985436961054802,
-0.004331689793616533,
-0.0020348685793578625,
-0.002372956834733486,
-0.0061769383028149605,
-0.00792243517935276,
0.009263720363378525,
-0.002794997999444604,
-0.014482708647847176,
-0.0004291231743991375,
0.006742516066879034,
0.01659279316663742,
-0.000600168015807867,
0.005371646489948034,
0.004851766861975193,
-0.03552734851837158,
0.011097533628344536,
0.020480260252952576,
-0.0030056063551455736,
0.003959979396313429
] | [
-0.41933107376098633,
0.18071123957633972,
-0.015073814429342747,
-0.15725483000278473,
-0.21580275893211365,
-0.48942121863365173,
0.13012029230594635,
-0.24606986343860626,
0.07015261799097061,
-0.7709208726882935,
0.009045688435435295,
-0.1263391673564911,
-1.0137920379638672,
-0.10220422595739365,
-0.052175067365169525,
0.312931627035141,
0.2064673751592636,
0.3524629771709442,
-0.3889605700969696,
-0.5748769044876099,
-0.07272722572088242,
-0.14401021599769592,
0.1456300914287567,
0.10749773681163788,
0.9810725450515747,
-0.5825415253639221,
0.08405563235282898,
-0.15522918105125427,
0.7861993312835693,
-0.03412284329533577,
-0.17991824448108673,
0.324580579996109,
0.09248015284538269,
-0.17938585579395294,
-0.4648742377758026,
-0.007388883735984564,
-0.3033777177333832,
-0.054901476949453354,
0.3756972551345825,
0.01650998368859291,
-0.4597446918487549,
-0.20486706495285034,
-0.46071088314056396,
0.24062754213809967,
-0.1082402914762497,
-0.4298538863658905,
-1.0900541543960571,
0.7892183661460876,
-0.4478966295719147,
-0.21761451661586761,
-0.1241605132818222,
0.5609568357467651,
-0.21314525604248047,
0.038933444768190384,
0.40404948592185974,
-0.18164502084255219,
-0.8264163732528687,
0.23894934356212616,
0.32623347640037537,
-0.22045762836933136,
0.38746964931488037,
-0.14138995110988617,
-0.17451795935630798,
0.306256502866745,
0.0977659821510315,
0.847946047782898,
-0.171499565243721,
-0.18153506517410278,
-0.3608323335647583,
-0.4525773525238037,
-0.21372421085834503,
-0.7095099091529846,
0.002441186923533678,
0.05025315657258034,
0.20389455556869507,
-0.03262852132320404,
-0.7131409049034119,
-0.6125792860984802,
-0.04302887246012688,
0.3316335678100586,
-0.20701605081558228,
0.07774902880191803,
-0.31483012437820435,
-0.02491813711822033,
0.4123370945453644,
0.05073618143796921,
-0.1523798704147339,
0.8347705006599426,
-0.3781701326370239,
0.2301853895187378,
-0.10959234833717346,
-0.0792284682393074,
0.4813395142555237,
0.00709037110209465,
0.38024282455444336,
0.06941626220941544,
-0.31060531735420227,
0.28953441977500916,
0.3407028019428253,
0.08523699641227722,
-0.560732901096344,
0.13089799880981445,
-0.049605369567871094,
-0.5427103638648987,
-0.46474725008010864,
-0.08606082946062088,
-0.016802599653601646,
-0.6562504768371582,
-0.6123706698417664,
-0.042987942695617676,
-0.2078956663608551,
-0.5477790236473083,
-0.6665876507759094,
-0.352111279964447,
-0.07513988763093948,
0.34378933906555176,
-0.18843939900398254,
-0.5722649693489075,
0.28612804412841797,
0.20020230114459991,
-0.5201659202575684,
1.1578185558319092,
-0.27215471863746643,
0.3834146559238434,
0.15790078043937683,
-0.2783518135547638,
0.1544548124074936,
0.3893965780735016,
-0.12872517108917236,
0.9103427529335022,
-0.31538867950439453,
0.928180456161499,
-0.19223161041736603,
0.47326359152793884,
-0.17641589045524597,
0.2835206687450409,
0.01676849275827408,
0.381219744682312,
0.08110181987285614,
-0.5528339743614197,
-0.7152464389801025,
-0.0062605938874185085,
-0.12630878388881683,
-0.15327325463294983,
-0.25914308428764343,
-0.1486390233039856,
-0.21539191901683807,
-0.22906050086021423,
-0.1446666121482849,
-0.7042648792266846,
0.28958624601364136,
-0.5739715695381165,
-0.15991215407848358,
0.48177364468574524,
0.13934095203876495,
0.2877226173877716,
0.4543217122554779,
0.3254828453063965,
-0.41661494970321655,
0.33509770035743713,
0.11901785433292389,
-0.07611976563930511,
-0.25551503896713257,
0.5977428555488586,
0.372416615486145,
0.286080539226532,
0.36370325088500977,
0.42192548513412476,
0.20587342977523804,
-0.5773836374282837,
0.03698248416185379,
-0.5056700110435486,
0.05767812579870224,
-0.30781635642051697,
-0.06335408985614777,
-0.16436295211315155,
0.6843751072883606,
0.0855584517121315,
0.47461578249931335,
-0.4486003518104553,
-0.7095775604248047,
-0.035759348422288895,
-0.3748607933521271,
0.16992804408073425,
0.6199036836624146,
0.16756227612495422,
0.09910769760608673,
0.15488290786743164,
-0.6048088073730469,
-0.202475443482399,
0.024193432182073593,
0.2610725462436676,
0.5545470714569092,
-0.4165743291378021,
1.2108206748962402,
-0.24314184486865997,
-0.28339096903800964,
1.2902839183807373,
0.2961259186267853,
0.3801203966140747,
-0.15271328389644623,
0.3815063536167145,
0.6863515377044678,
-0.6391649842262268,
-0.15671895444393158,
0.46639853715896606,
-0.16233736276626587,
0.10544620454311371,
0.1997753381729126,
0.013323540799319744,
0.37323427200317383,
-0.17862074077129364,
-0.02337064780294895,
-0.22180218994617462,
0.41338589787483215,
-0.36747342348098755,
0.1446845978498459,
-0.23763899505138397,
-0.34043076634407043,
0.25959083437919617,
0.12627403438091278,
-0.31503230333328247,
0.33102062344551086,
0.74984210729599,
-0.25047773122787476,
0.6195318102836609,
0.6218171119689941,
0.08421465009450912,
0.6730395555496216,
-0.1980201005935669,
0.16366060078144073,
-0.7478541731834412,
0.5017202496528625,
-0.28730347752571106,
-0.3105916678905487,
0.1805267632007599,
0.6464548110961914,
0.24206766486167908,
0.348661333322525,
0.06607653200626373,
0.016032900661230087,
0.5825451016426086,
-0.5655769109725952,
-0.28171420097351074,
-0.014946735464036465,
-0.3596988320350647,
-0.11952386051416397,
0.07811441272497177,
-0.770990788936615,
-0.14381924271583557,
-0.06643875688314438,
0.11981668323278427,
0.038940321654081345,
-0.4583989381790161,
0.306132435798645,
-0.0031346085015684366,
-0.58697909116745,
0.12808561325073242,
0.5638639330863953,
-0.27963563799858093,
0.07633639872074127,
-0.1985720545053482,
-0.1428609937429428,
0.6483738422393799,
-0.21918918192386627,
-0.15246625244617462,
-0.30556240677833557,
-0.15471282601356506,
1.0193575620651245,
0.6836786270141602,
0.604925811290741,
-0.013318348675966263,
-0.6324370503425598,
-0.16097696125507355,
0.03445417806506157,
-0.5222044587135315,
0.3317005932331085,
0.7245293855667114,
-0.09779731184244156,
-0.08491991460323334,
0.17305409908294678,
0.09466804563999176,
0.6129169464111328,
-0.12789492309093475,
-0.08157169818878174,
0.018324553966522217,
0.1440572440624237,
-0.6603937149047852,
-0.1898707002401352,
-0.21814243495464325,
-0.2292235642671585,
0.6087164282798767,
-0.5102395415306091,
-0.2822098135948181,
0.3911113739013672,
0.5155718326568604,
-0.03782019764184952,
0.21403494477272034,
0.5778892040252686,
-0.03567374125123024,
-0.03349589928984642,
0.41857483983039856,
-0.6801632642745972,
-0.01470387913286686,
-0.3751900792121887,
0.18467989563941956,
-0.30212751030921936,
-0.055178143084049225,
-5.838094234466553,
0.4040816128253937,
0.3543004095554352,
-0.13102464377880096,
-0.38205385208129883,
-0.35341784358024597,
0.9745734930038452,
-0.04985621199011803,
0.423864483833313,
-0.4621747136116028,
0.3065020442008972,
0.2516844868659973,
-0.08391576260328293,
-0.29762178659439087,
-0.3118494153022766,
-0.18941275775432587,
-0.0244140662252903,
0.038045939058065414,
0.6072461009025574,
0.25066840648651123,
-0.21648183465003967,
-0.24143387377262115,
0.4280708432197571,
0.02164146676659584,
-0.08370967954397202,
-0.0009648402337916195,
-0.2298610657453537,
0.5266907215118408,
-0.07212983816862106,
0.08576469123363495,
0.33818376064300537,
-0.7285144329071045,
0.23144835233688354,
-0.2024828940629959,
0.1443055123090744,
0.014379158616065979,
0.11297304928302765,
-0.2584220767021179,
-0.11719216406345367,
-0.08897924423217773,
0.6267876029014587,
0.007776884827762842,
-0.03284645825624466,
0.020673183724284172,
0.2626030445098877,
-0.5134499073028564,
0.06414590775966644,
0.1168968677520752,
-0.14129547774791718,
0.817518413066864,
0.1515367329120636,
-0.2549230754375458,
-0.11239351332187653,
0.3416242301464081,
0.6161211133003235,
0.7643236517906189,
-0.2843160331249237,
-0.09548449516296387,
-0.7138792872428894,
-0.23349373042583466,
-0.449485182762146,
-0.2585188150405884,
-0.6461461782455444,
-0.15738682448863983,
0.6895531415939331,
0.12459252774715424,
-0.663332998752594,
-0.021980909630656242,
0.7112429141998291,
-0.2226436883211136,
0.03026321716606617,
0.17268799245357513,
0.16583086550235748,
-0.6796116232872009,
0.2998020648956299,
-0.5843822956085205,
0.2820065915584564,
0.25772321224212646,
-0.27002620697021484,
-0.29935193061828613,
-0.5212960839271545,
0.0845789983868599,
-0.35779792070388794,
-0.3012041449546814,
0.2511538565158844,
-0.5447798371315002,
0.0427703782916069,
0.36537647247314453,
-0.2981005907058716,
0.3849506378173828,
0.5733000636100769,
-0.32137471437454224,
-0.06755834072828293,
0.3917504847049713,
-0.07738721370697021,
0.311815083026886,
-0.34809303283691406,
0.325488418340683,
0.7881538271903992,
0.03931243717670441,
1.05263090133667,
-0.18540059030056,
-0.38010209798812866,
-0.8876804709434509,
-0.5291113257408142,
0.2487141340970993,
-0.6077792644500732,
0.2697709798812866,
0.8979678153991699,
-0.7161075472831726,
0.04861351475119591,
0.023116735741496086,
-0.6229404211044312,
-0.305422842502594,
0.8006919622421265,
-0.05514620617032051,
-0.1123451516032219,
0.29955416917800903,
0.39120393991470337,
-0.2782842516899109,
0.3090928792953491,
0.4816276729106903,
-0.6383346319198608,
0.12963040173053741,
-0.08839725703001022,
0.509523868560791,
0.23276777565479279,
0.8034405708312988,
-0.5283648371696472,
-0.38496753573417664,
0.6087509393692017,
0.08641287684440613,
-0.2854343056678772,
-0.21574589610099792,
0.6831077337265015,
-0.12460153549909592,
-0.3806052505970001,
0.10262687504291534,
0.22217068076133728,
-0.36746782064437866,
0.3461149036884308,
-0.08096561580896378,
0.08707895129919052,
-0.17713859677314758,
0.37913402915000916,
-0.060960620641708374,
-0.48879483342170715,
0.1223771870136261,
-0.24251914024353027,
-0.5829201936721802,
0.28922978043556213,
-0.30318865180015564,
0.040603235363960266,
-0.19551554322242737,
-0.7770635485649109,
0.670886218547821,
0.5926569104194641,
0.1107226088643074,
0.2180255502462387,
-0.5147453546524048,
0.502993643283844,
0.0952068641781807,
-0.5261737704277039,
0.196910098195076,
-0.01157970167696476,
-0.1715729534626007,
0.2795005440711975,
-0.3933652639389038,
-0.6842394471168518,
0.05094997212290764,
-0.4841178059577942,
-0.37911027669906616,
0.035201285034418106,
-0.1984615921974182,
-0.023378431797027588,
-0.0016951663419604301,
-0.3457077145576477,
0.0032377387396991253,
0.3605225384235382,
0.05443067476153374,
-0.0667463019490242,
-0.7840235829353333,
-0.40364986658096313,
0.5060440897941589,
0.19839982688426971,
0.30845189094543457,
0.12129288911819458,
0.2340696156024933,
-0.33090341091156006,
-0.6556070446968079,
0.05208611488342285,
-0.12181205302476883,
0.40690094232559204,
-0.24867965281009674,
0.28257352113723755,
-0.030749505385756493,
-0.34098172187805176,
0.5913920998573303,
-0.039876267313957214,
-0.3081666827201843,
0.37325024604797363,
0.16115926206111908,
-0.297446608543396,
0.3900355398654938,
-0.10412881523370743,
0.2123037725687027,
-0.10906266421079636,
-0.0071672131307423115,
0.3723827004432678,
0.1642751693725586,
0.1866299957036972,
-0.872930645942688,
-0.09436806291341782,
0.49834632873535156,
0.006648719310760498,
-0.07396796345710754,
-0.20103131234645844,
-0.13737955689430237,
0.227461040019989,
0.18531882762908936,
-0.0062737115658819675,
-0.12135687470436096,
0.01841053180396557,
-0.255797803401947,
-0.08603432774543762,
0.31744900345802307,
0.37632185220718384,
-0.9767990708351135,
0.23878587782382965,
-0.08508197218179703,
0.42984268069267273,
-0.16206279397010803,
0.05722704902291298,
0.177060067653656,
-0.2777925133705139,
-0.25913137197494507,
0.1431238055229187,
-0.0014766179956495762,
-0.09244634956121445,
0.6943951845169067,
0.6584213376045227,
0.5183064937591553,
-0.311668336391449,
-0.10366208106279373,
0.16188104450702667,
0.6466065645217896,
0.3918907940387726,
-0.7533453702926636,
-0.4108598828315735,
0.32944369316101074,
0.24555997550487518,
-0.013533891178667545,
0.015503392554819584,
0.5618091821670532,
0.8427173495292664,
-0.3004952371120453,
-0.02004871517419815,
-0.16546736657619476,
-0.17268003523349762,
0.19312532246112823,
-0.42914512753486633,
0.3358047902584076,
-0.2540176808834076,
-0.00335235265083611,
0.2366170883178711,
0.14818447828292847,
-0.2884192168712616,
-0.274014949798584,
0.021450500935316086,
0.17649951577186584,
-0.5762320756912231,
-0.32020699977874756,
0.7424456477165222,
-0.1596967577934265,
-0.5334286689758301,
0.4860571324825287,
-0.15489964187145233,
0.1057012677192688,
-0.4444986879825592,
0.32470038533210754,
-0.21836593747138977,
-0.8754632472991943,
0.4539465606212616,
-0.42105481028556824,
0.49934065341949463,
-0.8701170086860657,
-0.38113513588905334,
-0.07291032373905182,
0.30049964785575867,
-0.03812557831406593,
-0.3694315552711487,
0.023711273446679115,
-0.9758412837982178,
-0.405668705701828,
0.22842346131801605,
0.1731734424829483,
0.09284044057130814,
0.2574814260005951,
-0.09180926531553268,
0.07158010452985764,
-0.4714813530445099,
0.5971093773841858,
-0.03818533942103386,
-0.23875147104263306,
-0.11656937003135681,
0.36810219287872314,
0.013127193786203861,
0.3638186454772949,
-0.3042067587375641,
-0.3389618992805481,
-0.16399867832660675,
-0.33994126319885254,
0.3656123876571655,
-0.15754468739032745,
-0.6526530385017395,
0.27630943059921265,
0.4279254078865051,
-0.5183902978897095,
-0.038878701627254486,
-0.0741925984621048,
0.3042513430118561,
0.28085869550704956,
0.034083593636751175,
0.03413180634379387,
-0.6130663156509399,
0.3234218955039978,
-0.08863218873739243,
-0.19826455414295197,
-0.1297251135110855,
0.5988600850105286,
0.8316794633865356,
0.20656408369541168,
0.01724117621779442,
0.48436811566352844,
0.22797323763370514,
0.15553052723407745,
0.14804090559482574,
-0.686552882194519,
-0.16395366191864014,
-0.24391867220401764,
0.2962830662727356,
0.653867781162262,
-0.31541699171066284,
-0.19265548884868622,
0.2009221613407135,
0.08558908104896545,
0.1549370437860489,
0.2545810639858246,
0.3520258665084839,
0.6607654094696045,
0.20293936133384705,
-0.692956805229187,
-0.5576573014259338,
0.3644045889377594,
-0.6683206558227539,
0.28165122866630554,
0.5622689723968506,
-0.2509143352508545,
-0.7257561087608337,
-0.23586808145046234,
-0.28920936584472656,
0.21148115396499634,
0.1777672916650772,
0.8149896264076233,
-0.09565958380699158,
-0.0052661169320344925,
0.33069664239883423,
0.11978225409984589,
0.5500706434249878,
-0.4362781047821045,
-0.5309232473373413,
-0.038369763642549515,
-0.17139394581317902,
0.09719368815422058,
-0.049003295600414276,
-0.4024776518344879,
0.07740485668182373,
-0.1713201105594635,
-0.06977003067731857,
0.5731431841850281,
-0.44892629981040955,
-0.051934003829956055,
-0.17165958881378174,
-0.770679235458374,
-0.5189793705940247,
-0.3082749545574188,
-0.0761527493596077,
-0.6702563762664795,
-0.30921298265457153,
0.16902996599674225,
0.15423788130283356,
-0.5212099552154541,
-0.22005502879619598,
0.2779430150985718,
0.25320348143577576,
0.11174953728914261,
-0.14738598465919495,
0.28634190559387207,
0.40471357107162476,
0.5922085642814636,
-0.3000059723854065,
0.39648422598838806,
-0.1923910528421402,
0.310985267162323,
-0.4399976134300232,
0.9027690291404724,
-0.3344554007053375,
-0.079503633081913,
-0.8130508661270142,
-0.29042747616767883,
1.4006319046020508,
0.8750284910202026,
-0.26025712490081787,
0.32417240738868713,
0.22718381881713867,
0.373820960521698,
0.2291877120733261,
-0.37086325883865356,
-0.21039433777332306,
-0.48946741223335266,
-0.17149482667446136,
-0.3454591929912567,
0.2458914816379547,
0.26840099692344666,
0.08200213313102722,
-0.003201500279828906,
0.28736963868141174,
0.4073280394077301,
-0.20530468225479126,
0.584717869758606,
-0.12967181205749512,
-0.25290659070014954,
-0.471895694732666,
0.26257750391960144,
-0.6084413528442383,
0.23708640038967133,
-0.19420671463012695,
-0.20355954766273499,
0.1990612894296646,
0.31425541639328003,
0.6101658344268799,
-0.0832093134522438,
-0.04254160076379776,
0.463725745677948,
-0.0330011211335659,
-0.3582112789154053,
-0.13462550938129425,
-0.6275938153266907,
-0.5812864899635315,
0.4912126958370209,
0.07054369896650314,
-0.30575379729270935,
0.5715155005455017,
0.07052061706781387,
-0.2375924289226532,
0.09962141513824463,
-0.09837627410888672,
0.09791304171085358,
-0.22169046103954315,
0.4465946853160858
] |
BACKGROUND: Influenza immunisation for healthcare workers is encouraged to protect their often vulnerable patients but also due to a perceived higher risk for influenza. We aimed to compare the risk of influenza infection in healthcare workers in acute hospital care with that in non-healthcare workers over the same season. METHODS: We conducted a prospective, multicentre cohort study during the 2006/07 influenza season in Berlin, Germany. Recruited participants gave serum samples before and after the season, and completed questionnaires to determine their relevant exposures and possible confounding factors. The main outcome measure was serologically confirmed influenza infection (SCII), defined as a fourfold or greater rise in haemagglutination inhibition antibody titres to a circulating strain of influenza (with post-season titre at least 1:40). Weekly mobile phone text messages were used to prompt participants to report respiratory illnesses during the influenza season. A logistic regression model was used to assess the influence of potential risk factors. RESULTS: We recruited 250 hospital healthcare workers (mean age 35.7 years) and 486 non-healthcare workers (mean age 39.2 years) from administrative centres, blood donors and colleges. Overall SCII attack rate was 10.6%. Being a healthcare worker was not a risk factor for SCII (relative risk 1.1, p = 0.70). The final multivariate model had three significant factors: living with children (odds ratio [OR] 3.7, p = 0.005), immunization (OR 0.50, p = 0.02), and - among persons living in households without children - ownership of a car (OR 3.0, p = 0.02). Living with three or more children (OR 13.8, p < 0.01) was a greater risk than living with one or two children (OR 5.3, p = 0.02). 30% of participants with SCII reported no respiratory illness. Healthcare workers were at slightly higher risk of reporting any respiratory infection than controls (adjusted OR 1.3, p = 0.04, n = 850). CONCLUSIONS: Our results suggest that healthcare workers in hospitals do not have a higher risk of influenza than non-healthcare workers, although their risk of any respiratory infection is slightly raised. Household contacts seem to be more important than exposure to patients. Car ownership is a surprise finding which needs further exploration. Asymptomatic infections are common, accounting for around a third of serologically confirmed infections. | [
0.003795057535171509,
0.023263616487383842,
0.0033846846781671047,
0.02513596974313259,
0.008727585896849632,
0.0015654307790100574,
0.008094144985079765,
0.00554471742361784,
-0.013616944663226604,
-0.011991248466074467,
-0.00661891233175993,
0.0159201230853796,
-0.003178583923727274,
0.0027430281043052673,
-0.0077749136835336685,
-0.021067515015602112,
-0.018346354365348816,
0.023055413737893105,
0.011006992310285568,
0.000017734244465827942,
-0.007104380056262016,
-0.005257125943899155,
0.009434092789888382,
-0.00539019238203764,
0.014974977821111679,
0.00999559834599495,
0.004698452539741993,
-0.021044060587882996,
-0.010601939633488655,
-0.000284531619399786,
-0.024885807186365128,
0.030841659754514694,
0.017591584473848343,
0.001919860253110528,
0.010361664928495884,
0.007027802057564259,
-0.00020138898980803788,
0.030938588082790375,
-0.020559003576636314,
-0.0035454952158033848,
0.028175044804811478,
-0.01385367102921009,
-0.000019613071344792843,
0.0027041155844926834,
-0.006375703029334545,
0.02747800201177597,
-0.006697334814816713,
-0.01863963156938553,
0.0023684296756982803,
0.0034598628990352154,
0.003707878291606903,
0.009233164601027966,
0.002125564031302929,
-0.006974627263844013,
-0.006003872491419315,
0.015132592990994453,
0.0170219037681818,
0.022751223295927048,
-0.005627547390758991,
0.005970054771751165,
-0.0058751762844622135,
-0.0022283834405243397,
0.015265416353940964,
0.001332044368609786,
0.029982874169945717,
-0.06689468026161194,
0.024288607761263847,
0.0018403059802949429,
0.01783914864063263,
0.0009204477537423372,
0.014408707618713379,
0.007679429836571217,
-0.007821489125490189,
-0.00032235076650977135,
-0.020672062411904335,
0.0253470279276371,
0.015187818557024002,
0.005277613177895546,
0.004427831154316664,
0.014154311269521713,
-0.015075376257300377,
0.01399752963334322,
0.00905555859208107,
0.02880067564547062,
0.018596306443214417,
0.0007299557328224182,
-0.019915219396352768,
-0.004526336211711168,
-0.020351646468043327,
0.00502467667683959,
0.004663743078708649,
0.006820766255259514,
-0.014349575154483318,
-0.008791999891400337,
0.0009299110388383269,
-0.002210017992183566,
-0.01084025576710701,
0.018452845513820648,
-0.015318789519369602,
-0.0030235592275857925,
0.0005472252378240228,
-0.0007383043994195759,
0.01881815679371357,
0.005897687282413244,
-0.001582864671945572,
0.0030232302378863096,
0.0015488844364881516,
0.013251150958240032,
0.007630879059433937,
0.002203551819548011,
0.01595281809568405,
0.004211358726024628,
0.012141859158873558,
0.010232919827103615,
0.00901871919631958,
0.014563431032001972,
-0.0003951927646994591,
0.00938391126692295,
0.006454333662986755,
-0.03201889619231224,
0.02759667858481407,
0.006025484763085842,
0.0038791995029896498,
0.014875450171530247,
-0.0031328555196523666,
-0.0006705643609166145,
-0.00020569562911987305,
-0.020625390112400055,
0.00965416431427002,
0.011463193222880363,
-0.009653044864535332,
-0.02440350130200386,
-0.01554835680872202,
0.0014637373387813568,
0.006810016930103302,
-0.0036197795998305082,
-0.00708775082603097,
-0.00007599079981446266,
-0.008315362967550755,
0.0030414098873734474,
-0.021097969263792038,
0.01392285618931055,
-0.005164852365851402,
0.007402318064123392,
-0.007330634165555239,
0.0034889867529273033,
0.009831506758928299,
0.012569032609462738,
0.020716480910778046,
0.020637325942516327,
0.014404570683836937,
0.0034940573386847973,
-0.012002084404230118,
-0.01064625196158886,
-0.010684210807085037,
-0.005846644286066294,
0.004858854226768017,
-0.005594606511294842,
-0.030770761892199516,
-0.006561171263456345,
0.012750634923577309,
-0.009536533616483212,
0.00792321003973484,
0.007933957502245903,
0.0039794351905584335,
-0.0075473478063941,
0.023141775280237198,
-0.011562634259462357,
-0.0004740259610116482,
0.0029332060366868973,
-0.014509350061416626,
0.0017242520116269588,
-0.0019540691282600164,
0.009338964708149433,
0.03108103759586811,
-0.014127898961305618,
0.008896682411432266,
0.008685275912284851,
0.004433784633874893,
0.06656624376773834,
-0.011625279672443867,
-0.008364276960492134,
-0.011385738849639893,
0.013387700542807579,
-0.003970679361373186,
0.01426121685653925,
0.043275266885757446,
0.00040609436109662056,
0.008416162803769112,
-0.014402530156075954,
-0.008729338645935059,
-0.004084918648004532,
0.020140251144766808,
-0.005255651194602251,
-0.0042398590594530106,
0.004300033673644066,
0.013934529386460781,
0.00150358269456774,
-0.01991783268749714,
-0.003124802140519023,
0.003823651233687997,
-0.0016824748599901795,
0.04081534966826439,
0.008524695411324501,
-0.011089633218944073,
0.010332579724490643,
0.020484209060668945,
-0.02233779802918434,
-0.015078353695571423,
-0.01678745076060295,
0.01738731749355793,
-0.004570890683680773,
-0.002800573594868183,
-0.011989272199571133,
0.009123314172029495,
-0.0049040974117815495,
0.020218539983034134,
0.00996257271617651,
-0.017384512349963188,
-0.012871753424406052,
0.00088434451026842,
0.02008645609021187,
-0.02005980722606182,
-0.013913357630372047,
0.0036632458213716745,
-0.01301582157611847,
-0.005524409003555775,
0.012617163360118866,
-0.015236801467835903,
0.022243395447731018,
-0.018152672797441483,
-0.018277669325470924,
-0.006626490503549576,
-0.01825292408466339,
0.002667208667844534,
0.004400183446705341,
0.00819404423236847,
-0.011748991906642914,
0.0028947675600647926,
-0.013863633386790752,
0.007807973772287369,
-0.021498966962099075,
0.0164032019674778,
0.01375957578420639,
0.013104054145514965,
-0.003194317454472184,
-0.000702394638210535,
0.024343552067875862,
-0.037957265973091125,
0.015987064689397812,
0.0052832444198429585,
-0.0024318257346749306,
-0.0025982605293393135,
0.007072551175951958,
0.017261160537600517,
-0.012087281793355942,
-0.008307408541440964,
-0.0031349994242191315,
0.024541623890399933,
-0.004467753693461418,
0.013270426541566849,
0.0062357890419662,
-0.012600870802998543,
-0.0027211718261241913,
-0.008978266268968582,
0.030273104086518288,
-0.00424227025359869,
0.009855407290160656,
0.0069547174498438835,
0.003829243127256632,
0.0042311400175094604,
-0.009798262268304825,
-0.005531910341233015,
-0.08176662027835846,
-0.0186832994222641,
-0.003816464450210333,
-0.024505803361535072,
0.008591104298830032,
-0.00570314098149538,
0.008870520628988743,
-0.0034967921674251556,
-0.007623665500432253,
0.016812629997730255,
0.024368727579712868,
0.017377151176333427,
-0.0023370918352156878,
0.012223539873957634,
-0.028295282274484634,
-0.005099299363791943,
0.0006715705967508256,
0.023085663095116615,
-0.009942546486854553,
0.009491254575550556,
-0.01729821041226387,
0.0049386583268642426,
0.030522916465997696,
-0.03257794305682182,
0.025206100195646286,
0.00514705665409565,
0.0021441427525132895,
0.0002876858925446868,
0.029230250045657158,
0.014179978519678116,
-0.008100458420813084,
-0.004667593166232109,
-0.021568890661001205,
0.0008084382861852646,
-0.019022293388843536,
-0.004352273885160685,
0.011792791076004505,
-0.004923577886074781,
-0.008040862157940865,
-0.02327841892838478,
0.01554445456713438,
0.009948059916496277,
0.007891925051808357,
0.0009784918511286378,
0.000054503208957612514,
-0.005162947345525026,
0.00006926036439836025,
0.0077902269549667835,
0.016843661665916443,
-0.01281748153269291,
-0.013015414588153362,
-0.021973155438899994,
-0.0008598887361586094,
0.013638458214700222,
-0.010786212980747223,
-0.00712702888995409,
-0.0018554989947006106,
0.020640555769205093,
-0.01061332132667303,
-0.011257035657763481,
-0.014660445973277092,
0.029258238151669502,
-0.02702139876782894,
0.025391340255737305,
0.006020755507051945,
0.013153621926903725,
0.008230983279645443,
-0.009598828852176666,
-0.004690778441727161,
-0.005486016161739826,
-0.011447668075561523,
-0.006708312314003706,
0.013325663283467293,
-0.012519682757556438,
0.0035943726543337107,
0.001551408669911325,
-0.006723316386342049,
-0.006350046955049038,
0.001709695439785719,
0.02366260252892971,
-0.005019316915422678,
-0.001810446847230196,
-0.03168430179357529,
-0.010553263127803802,
-0.015625782310962677,
-0.0013949759304523468,
0.016979921609163284,
0.006541151087731123,
0.004619327373802662,
-0.02312767133116722,
-0.001042145537212491,
0.028811965137720108,
0.0016755459364503622,
0.007287332322448492,
-0.020695488899946213,
0.003143101930618286,
0.0012941048480570316,
0.0015781177207827568,
-0.015663890168070793,
0.0077611892484128475,
-0.009310878813266754,
-0.021820707246661186,
0.0016062548384070396,
-0.014856008812785149,
0.004737942013889551,
0.013607116416096687,
0.014645081013441086,
-0.008733699098229408,
-0.021189674735069275,
-0.016184654086828232,
-0.001967557705938816,
-0.00008411845192313194,
-0.006551693193614483,
0.003970771096646786,
0.01466868631541729,
-0.020457370206713676,
0.008173737674951553,
0.0015592518029734492,
0.07246487587690353,
-0.033943966031074524,
0.015422466211020947,
-0.012660710141062737,
0.008076281286776066,
-0.008989674970507622,
0.004771311767399311,
-0.010649321600794792,
0.009733568876981735,
-0.009995485655963421,
0.012038104236125946,
-0.03809599205851555,
-0.020265523344278336,
-0.028949517756700516,
0.009514049626886845,
-0.0007367898942902684,
-0.00011460762470960617,
-0.021129988133907318,
0.010765206068754196,
-0.0001994525082409382,
0.01867903582751751,
0.02224007248878479,
0.009882115758955479,
-0.0006401243153959513,
0.009089164435863495,
0.0226755291223526,
0.027824431657791138,
-0.012358592823147774,
-0.00108443689532578,
-0.006630075164139271,
-0.02683759480714798,
0.009374539367854595,
-0.0018600012408569455,
-0.01100245863199234,
0.005642903037369251,
0.0029195668175816536,
0.006008987780660391,
0.002782150637358427,
0.004108660854399204,
-0.010272515937685966,
-0.005725724156945944,
-0.012036638334393501,
-0.0007756957784295082,
0.014113780111074448,
-0.04371581971645355,
0.00871405191719532,
-0.033571407198905945,
-0.005827021319419146,
0.0037519382312893867,
0.011809310875833035,
-0.010423356667160988,
0.003847775049507618,
0.00482654245570302,
0.018507547676563263,
-0.03184158354997635,
0.010529906488955021,
-0.005634500179439783,
-0.0028179255314171314,
0.0036755697801709175,
-0.008806735277175903,
-0.002158861607313156,
-0.020350981503725052,
0.006167428568005562,
-0.0199701189994812,
-0.00033272895961999893,
0.006377724930644035,
-0.01229771226644516,
0.003048876067623496,
-0.00568885775282979,
0.0006026471965014935,
-0.0016490158159285784,
-0.02050548605620861,
-0.0042576054111123085,
-0.002482944168150425,
-0.04692402482032776,
-0.005945139564573765,
-0.03854893893003464,
-0.0036419357638806105,
0.000921950617339462,
0.005801870487630367,
-0.02872363105416298,
-0.013243937864899635,
0.023099923506379128,
0.01587628200650215,
0.006604373455047607,
0.009961038827896118,
-0.0017904378473758698,
-0.0745462030172348,
-0.01761993020772934,
-0.005637010559439659,
-0.008825606666505337,
-0.010424205102026463,
-0.009186596609652042,
-0.023913875222206116,
-0.013689719140529633,
-0.019571855664253235,
-0.011417875066399574,
0.009663736447691917,
0.011520443484187126,
0.012110764160752296,
0.0031114532612264156,
0.017889954149723053,
-0.012025421485304832,
-0.034895069897174835,
-0.0102184247225523,
-0.01982053741812706,
0.008762910962104797,
0.007821593433618546,
0.03705577924847603,
-0.04703560099005699,
-0.011335358954966068,
0.01466812752187252,
-0.08102643489837646,
0.008539439179003239,
0.0024558869190514088,
-0.054051704704761505,
0.014005844481289387,
-0.018170014023780823,
0.004173442255705595,
-0.007324249483644962,
-0.01781175471842289,
-0.01632327400147915,
-0.003047236707061529,
0.006132853217422962,
-0.0007358656730502844,
-0.0019044503569602966,
0.015290080569684505,
-0.0005443227710202336,
0.01388505194336176,
0.01509256474673748,
-0.003960068803280592,
-0.008340911939740181,
0.005364415235817432,
-0.002228670986369252,
-0.0059196120128035545,
0.012915513478219509,
-0.007772160228341818,
0.00015079043805599213,
0.0028766265604645014,
0.009279994294047356,
0.008770359680056572,
-0.021456213667988777,
-0.005965581629425287,
-0.0005973163060843945,
0.0018151586409658194,
0.0033065462484955788,
0.042447835206985474,
-0.006131856702268124,
0.02656470239162445,
-0.004234509076923132,
-0.0006366511806845665,
0.012459684163331985,
-0.008051957935094833,
-0.00533391535282135,
0.033088795840740204,
0.01869506761431694,
0.0022747893817722797,
-0.006398721598088741,
0.010310053825378418,
-0.0024609165266156197,
0.025144869461655617,
-0.002858326304703951,
0.0041046361438930035,
0.009818418882787228,
-0.0032657438423484564,
-0.005392996594309807,
0.008458155207335949,
-0.004741642624139786,
-0.009373459964990616,
-0.00035433750599622726,
0.007180294021964073,
0.015278784558176994,
-0.002286313334479928,
-0.0179403405636549,
-0.015514611266553402,
0.07172592729330063,
0.0036294434685260057,
0.008226821199059486,
0.0003373473882675171,
0.015671025961637497,
-0.0025454785209149122,
0.00780471321195364,
-0.015714695677161217,
-0.031105902045965195,
-0.004182758741080761,
0.016750743612647057,
-0.009228043258190155,
-0.01686382293701172,
0.009368288330733776,
0.007822711952030659,
-0.009376597590744495,
-0.006572803482413292,
0.000529236625880003,
-0.05981876701116562,
0.010810916312038898,
0.004139364697039127,
0.0037459013983607292,
-0.03445357829332352,
0.0003204013919457793,
0.025195425376296043,
-0.004963229410350323,
-0.0019325537141412497,
-0.009046917781233788,
0.0014714943245053291,
-0.0033331699669361115,
-0.005824551917612553,
0.019490055739879608,
0.009016752243041992,
0.0006052395328879356,
0.013154302723705769,
-0.012645591981709003,
0.016768667846918106,
0.003085230477154255,
0.005746102891862392,
0.024725789204239845,
0.023658815771341324,
0.005839774385094643,
0.013470064848661423,
0.010258402675390244,
0.014220939949154854,
-0.032357580959796906,
-0.0010099154897034168,
-0.02359912544488907,
0.023529447615146637,
0.020332064479589462,
0.0017764698714017868,
0.010893963277339935,
-0.011866763234138489,
-0.02441326342523098,
0.0013782894238829613,
-0.009952095337212086,
-0.004498486872762442,
0.01512134913355112,
0.006577149033546448,
-0.0008868919685482979,
-0.010129909962415695,
-0.011898893862962723,
0.021497488021850586,
-0.015843410044908524,
0.005611587315797806,
0.0019139426294714212,
0.027734268456697464,
-0.010329270735383034,
-0.0060416776686906815,
0.010605129413306713,
-0.0034256496001034975,
0.01755433902144432,
0.00525658531114459,
-0.013273519463837147,
0.016375841572880745,
-0.005368760786950588,
0.02065027877688408,
-0.005196647718548775,
0.014636832289397717,
0.009852994233369827,
-0.011613018810749054,
0.005718419328331947,
0.02007819153368473,
0.03870467469096184,
-0.0203719362616539,
0.00001613236963748932,
0.000019465573132038116,
-0.008033850230276585,
-0.011019770987331867,
0.01054009422659874,
-0.016233036294579506,
0.015274737030267715,
-0.0012725646374747157,
-0.01604226976633072,
0.011528672650456429,
0.03484877198934555,
0.032658129930496216,
0.0060614305548369884,
0.015560525469481945,
-0.0031967712566256523,
0.004328701179474592,
-0.0024170060642063618,
-0.0001661886926740408,
-0.013084199279546738,
-0.0007159418310038745,
-0.009350735694169998,
0.011296877637505531,
0.007466360926628113,
-0.0038529986049979925,
-0.028663478791713715,
0.0040025897324085236,
-0.015674138441681862,
0.03227159380912781,
0.015223445370793343,
0.0016185920685529709,
0.030440794304013252,
0.003220540704205632,
0.007563920225948095,
-0.012930149212479591,
-0.0030689151026308537,
-0.01692846789956093,
0.008511990308761597,
-0.015381313860416412,
0.02178972400724888,
-0.003077233210206032,
-0.02021152339875698,
-0.005208595655858517,
0.016636237502098083,
-0.0063204835169017315,
0.031394802033901215,
0.004580152221024036,
0.00897511001676321,
-0.022126324474811554,
-0.01283576712012291,
-0.0049188751727342606,
0.0018101208843290806,
-0.008599413558840752,
-0.013454467058181763,
-0.0025625021662563086,
0.01940009370446205,
0.001049563754349947,
0.0043500252068042755,
0.003931946586817503,
-0.04197821021080017,
0.011670089326798916,
0.02566222846508026,
-0.011910532601177692,
-0.0021061680745333433,
0.0160564873367548,
0.006450454704463482,
0.0005878850352019072,
0.02483125776052475,
0.0035898922942578793,
-0.003888833336532116,
-0.02249620109796524,
0.004621704109013081,
0.006964295171201229,
-0.013459421694278717,
-0.021753331646323204,
-0.00630983104929328,
0.00603021215647459,
-0.019287697970867157,
0.032709501683712006,
0.011611009016633034,
-0.014182274229824543,
0.00068691186606884,
0.005197625607252121,
0.0015986745711416006,
-0.027160512283444405,
-0.001775185577571392,
0.005636448506265879,
-0.013995666988193989,
0.01935727894306183,
0.008062433451414108,
-0.006956322118639946,
-0.013411873951554298,
0.010774929076433182,
0.01926868036389351,
-0.012465261854231358,
0.014598596841096878,
-0.005376617424190044,
-0.01274995505809784,
-0.01085602305829525,
-0.009027525782585144,
-0.00525251030921936,
0.01563500612974167,
-0.017757151275873184,
0.008178750053048134,
0.023315751925110817,
-0.01602644845843315,
-0.007823221385478973,
0.003615826368331909,
-0.022851034998893738,
-0.009876895695924759,
0.00008525536395609379,
-0.030875034630298615,
-0.036470793187618256,
-0.015625203028321266,
-0.0025458596646785736,
0.015384828671813011,
-0.019965074956417084,
-0.021496780216693878
] | [
0.6400383114814758,
-0.1823805570602417,
-0.31875720620155334,
-0.06351452320814133,
0.10034957528114319,
0.3913445770740509,
0.6378532648086548,
0.0038854535669088364,
-0.2911045551300049,
-0.38371413946151733,
0.03468295931816101,
-0.32999303936958313,
0.026167582720518112,
-0.08554171770811081,
-0.034810345619916916,
0.41393595933914185,
0.4270804524421692,
0.23757930099964142,
0.02750510722398758,
-0.1740243285894394,
-0.28140759468078613,
-0.27797722816467285,
-0.014059106819331646,
0.43800562620162964,
0.10249178856611252,
-0.17958073318004608,
0.5393103361129761,
-0.18772852420806885,
0.289852499961853,
-0.3412913382053375,
-0.015601440332829952,
0.5458319187164307,
-0.10463316738605499,
-0.4708893597126007,
0.10003039240837097,
0.11864209920167923,
0.08362843841314316,
0.395526260137558,
-0.11300311237573624,
-0.565934419631958,
-0.1582912802696228,
-0.0067872824147343636,
0.005266839638352394,
0.11074019968509674,
-0.20581424236297607,
-0.6996991038322449,
-0.996131181716919,
0.4925699830055237,
-0.3756786286830902,
-0.04022790119051933,
0.11771874129772186,
-0.12374791502952576,
0.3672564625740051,
0.09262063354253769,
-0.14187075197696686,
0.4402054250240326,
-0.3394911289215088,
0.03537222743034363,
0.04167922958731651,
-0.36908355355262756,
0.11056259274482727,
-0.08665381371974945,
-0.12776286900043488,
0.22286491096019745,
-0.23625999689102173,
0.3594953715801239,
0.1718376874923706,
0.20658764243125916,
0.5590564012527466,
-0.5690089464187622,
-0.08641236275434494,
-0.15583351254463196,
-0.5242302417755127,
0.006434089038521051,
0.17687246203422546,
-0.07174889743328094,
0.09861748665571213,
-0.2765628397464752,
0.040579408407211304,
0.3115452229976654,
-0.18214139342308044,
-0.34292182326316833,
0.14391279220581055,
-0.8983059525489807,
1.0577826499938965,
0.22647975385189056,
-0.25556671619415283,
0.4432668387889862,
-0.025321414694190025,
-0.40743520855903625,
0.10332111269235611,
-0.18582721054553986,
0.68665611743927,
0.37739360332489014,
0.16789674758911133,
0.34601256251335144,
-0.10809081047773361,
0.012706637382507324,
0.16602930426597595,
-0.16479365527629852,
-0.6200165748596191,
-0.005433743819594383,
-0.22358128428459167,
0.16173040866851807,
-0.4541020393371582,
-0.07256315648555756,
-0.12185737490653992,
-0.2615175247192383,
-0.6220029592514038,
0.1578880250453949,
-0.283297061920166,
-0.2768530547618866,
0.0018729731673374772,
-0.3222920000553131,
-0.3859410583972931,
0.12291532009840012,
0.39358794689178467,
-0.4440385103225708,
-0.12967436015605927,
0.3982483148574829,
-0.30169978737831116,
0.8800655007362366,
-0.24214325845241547,
0.34775054454803467,
-0.2473367303609848,
0.13996341824531555,
0.6542569994926453,
0.21702590584754944,
-0.12872721254825592,
0.20267675817012787,
0.029871191829442978,
0.5071163177490234,
-0.2636650502681732,
0.4101323187351227,
0.17168472707271576,
-0.13499665260314941,
-0.08988074213266373,
0.5472793579101562,
-0.04769685119390488,
0.1071808785200119,
-0.38055312633514404,
-0.5578446388244629,
-0.14899636805057526,
0.16046352684497833,
-0.10482242703437805,
-0.36343300342559814,
-0.19278916716575623,
-0.29091140627861023,
-0.04976767674088478,
-0.44152167439460754,
0.3062063455581665,
0.16119161248207092,
-0.45269685983657837,
-0.06273693591356277,
-0.031974732875823975,
0.7065384984016418,
-0.24959439039230347,
0.07955316454172134,
-0.1158532053232193,
-0.021515563130378723,
0.7118225693702698,
0.7460169792175293,
-0.31558459997177124,
0.095054030418396,
0.7132686972618103,
0.11193814128637314,
-0.1882825791835785,
0.25920569896698,
-0.037037234753370285,
0.21188987791538239,
-0.4595475196838379,
0.07534440606832504,
-0.11408999562263489,
-0.4546889662742615,
-0.2597826421260834,
0.34669196605682373,
-0.05233074352145195,
0.17657390236854553,
0.2577344477176666,
0.2674172818660736,
-0.40285617113113403,
-0.17095234990119934,
-0.351114422082901,
-0.7538471221923828,
0.1790754795074463,
-0.05742841586470604,
0.22270958125591278,
-0.12488768994808197,
-0.24934948980808258,
0.1554877609014511,
-0.21348467469215393,
-0.24100089073181152,
0.3852193355560303,
-0.7236654162406921,
1.059912085533142,
-0.36849430203437805,
-0.10074413567781448,
1.2565444707870483,
-0.012629500590264797,
0.047767944633960724,
-0.024408411234617233,
-0.07499933242797852,
0.6837762594223022,
-0.34435775876045227,
-0.4928983747959137,
-0.0949709564447403,
-0.00804886408150196,
-0.39820796251296997,
-0.1295548677444458,
0.05222383886575699,
0.4809730648994446,
-0.08349350094795227,
-0.2413102239370346,
-0.21527276933193207,
-0.02957737259566784,
0.37185975909233093,
-0.5447269678115845,
0.29787564277648926,
0.4456446170806885,
-0.18667548894882202,
0.29708579182624817,
-0.6232653856277466,
0.293740838766098,
0.33653777837753296,
-0.10462676733732224,
0.30347344279289246,
0.5092429518699646,
0.062433872371912,
1.0517886877059937,
-0.989851176738739,
0.1616201102733612,
-0.2964150905609131,
0.29511210322380066,
-0.7871472835540771,
-0.22223328053951263,
0.11188019067049026,
-0.18553781509399414,
-0.08094858378171921,
-0.06480208039283752,
0.1910165399312973,
0.576999306678772,
0.25963926315307617,
-0.36326155066490173,
0.40870508551597595,
0.06416764110326767,
-0.15965904295444489,
0.11296449601650238,
0.10237988829612732,
-0.5995720028877258,
0.07569824904203415,
0.26908478140830994,
0.32242751121520996,
-0.019316712394356728,
-0.41657575964927673,
-0.00985288992524147,
0.009460224770009518,
-0.03312738612294197,
-0.5768260955810547,
0.5310272574424744,
-0.1861894726753235,
0.4333345890045166,
0.34012308716773987,
0.0787617564201355,
0.24627573788166046,
0.8049805164337158,
-0.5645111203193665,
-0.5909570455551147,
-0.8474326729774475,
0.5642355680465698,
0.230936199426651,
0.7333954572677612,
0.19424371421337128,
-0.4395959973335266,
0.13328474760055542,
0.07205035537481308,
-0.7602458000183105,
-0.039195746183395386,
0.9164644479751587,
-0.3857783079147339,
-0.28645089268684387,
-0.2921324372291565,
0.04568558558821678,
0.6062938570976257,
-0.09056618064641953,
-0.16206128895282745,
-0.45249325037002563,
-0.23761720955371857,
0.10358386486768723,
-0.506512463092804,
-0.2092810571193695,
0.2053777277469635,
0.5077019929885864,
-0.32248449325561523,
-0.023548642173409462,
0.1090870127081871,
0.42589375376701355,
-0.35940372943878174,
0.47530409693717957,
0.7944731116294861,
-0.1762264370918274,
-0.17113274335861206,
0.2594700753688812,
-0.002584735630080104,
-0.051619477570056915,
-0.09751813858747482,
0.011717969551682472,
-0.5322394967079163,
-0.3295519948005676,
-6.14436149597168,
0.1276566982269287,
-0.12131573259830475,
-0.24854551255702972,
-0.30725258588790894,
0.282825231552124,
0.9985835552215576,
-0.07279115915298462,
0.20615960657596588,
0.1904032975435257,
0.649776041507721,
0.46550339460372925,
-0.05940978601574898,
0.3644763231277466,
0.4974533021450043,
0.20395976305007935,
0.19541479647159576,
-0.1371949315071106,
0.17656713724136353,
0.18391531705856323,
-0.11456000059843063,
0.03149977698922157,
0.06500144302845001,
0.461029589176178,
0.42021283507347107,
0.24942220747470856,
-0.9982661604881287,
0.3157578706741333,
-0.11677778512239456,
0.10031841695308685,
0.48134130239486694,
-0.7439308762550354,
0.07146516442298889,
0.12280625849962234,
-0.13168153166770935,
0.3007355332374573,
0.3255636394023895,
-0.10053756833076477,
-0.22815808653831482,
-0.19691967964172363,
-0.00966019369661808,
0.4600750505924225,
-0.22060611844062805,
-0.13382630050182343,
-0.023145360872149467,
0.05364605411887169,
0.17665328085422516,
0.18486395478248596,
-0.09478877484798431,
0.8001027703285217,
0.0640886127948761,
0.14126215875148773,
0.05964604765176773,
0.6384838819503784,
-0.16504117846488953,
-0.0792374387383461,
-0.08674076944589615,
0.7647197246551514,
-0.26224732398986816,
0.2968471944332123,
-0.020893773064017296,
-0.17142803966999054,
0.10813328623771667,
-0.4902556240558624,
0.2626134753227234,
0.11869354546070099,
-0.5921024084091187,
-0.3164273500442505,
-0.26163992285728455,
0.4038105905056,
-0.09718558192253113,
-0.14159324765205383,
0.20942161977291107,
-0.8707402944564819,
-0.06508072465658188,
-0.6192032098770142,
0.1023823469877243,
-0.33822014927864075,
0.2997639775276184,
-0.17406362295150757,
-0.15400637686252594,
-0.20775291323661804,
0.3665885031223297,
-0.07598341256380081,
0.22397266328334808,
0.38436245918273926,
0.1896308809518814,
-0.3290987014770508,
-0.2589646577835083,
0.05151551589369774,
0.43356895446777344,
-0.4270992577075958,
-0.16333502531051636,
0.03616803511977196,
0.00984251219779253,
0.8774042725563049,
0.2575426399707794,
-0.3963281810283661,
0.42689844965934753,
-0.3835224211215973,
0.6306015253067017,
-0.20021340250968933,
-0.48261645436286926,
-0.9219333529472351,
0.009804420173168182,
-0.08465774357318878,
-0.5834981203079224,
-0.011305835098028183,
1.12794828414917,
-0.7651407718658447,
-0.03745173290371895,
0.2156933695077896,
-0.09997181594371796,
-0.32293951511383057,
0.4705718755722046,
-0.20388688147068024,
0.1976005882024765,
0.007081143092364073,
0.7112135887145996,
-0.09424657374620438,
0.2652120590209961,
-0.12276098132133484,
-0.1463547646999359,
0.5522865056991577,
0.10279770940542221,
-0.20245355367660522,
0.34949856996536255,
0.24329149723052979,
-0.7111482620239258,
-0.158950537443161,
-0.07121600955724716,
0.27581536769866943,
-0.4363056421279907,
-0.1465195119380951,
0.2684081792831421,
0.21866610646247864,
-0.36157768964767456,
-0.2101479321718216,
0.3161592483520508,
0.2504805028438568,
0.004927801433950663,
-0.14192213118076324,
-0.30975106358528137,
0.5462945699691772,
-0.03416972607374191,
0.06517859548330307,
-0.19505061209201813,
-0.20374299585819244,
-0.2861085534095764,
-0.26878485083580017,
-0.031199075281620026,
0.18483592569828033,
0.014239628799259663,
0.2134043574333191,
-0.6957618594169617,
-0.0700889304280281,
0.6280292868614197,
0.021075410768389702,
0.031312599778175354,
-0.3754484951496124,
0.5206267833709717,
0.15038436651229858,
-1.3590216636657715,
-0.13709887862205505,
0.12515224516391754,
-0.4335826337337494,
0.02492702193558216,
-0.34507110714912415,
0.10882198810577393,
0.08415408432483673,
0.04938013479113579,
-0.6320752501487732,
-0.08025948703289032,
0.19882823526859283,
-0.05747068673372269,
0.14814606308937073,
-0.31297504901885986,
0.13310506939888,
-0.27209997177124023,
0.3560359477996826,
0.41231340169906616,
-0.28370997309684753,
-0.671801745891571,
0.16213677823543549,
0.586004912853241,
0.6218417882919312,
-0.1723833978176117,
-0.4666311740875244,
-0.14585478603839874,
0.045892372727394104,
0.38284116983413696,
-0.0894303172826767,
0.4261690080165863,
0.0680650919675827,
-0.14830096065998077,
-0.2180863618850708,
-0.17086602747440338,
0.15908627212047577,
-0.11317580193281174,
-0.19286708533763885,
-0.13360996544361115,
0.22424662113189697,
-0.06165410578250885,
0.1434759497642517,
0.03915005177259445,
-0.22990259528160095,
-0.2468714416027069,
0.08140724152326584,
-0.1546434760093689,
-0.3071819543838501,
-0.20346319675445557,
-0.43392589688301086,
-0.3251374363899231,
0.698542058467865,
-0.4308956563472748,
0.34169307351112366,
-0.16902300715446472,
-0.3974192142486572,
-0.05259307101368904,
0.6783133745193481,
-0.16590335965156555,
0.232575923204422,
-0.264241099357605,
-0.38982200622558594,
-0.28548866510391235,
0.30770713090896606,
0.7543860673904419,
-0.8966531753540039,
-0.3947531282901764,
0.22310657799243927,
-0.20580756664276123,
0.06741882860660553,
0.2665010690689087,
-0.226589173078537,
-0.6141360402107239,
-0.017586803063750267,
0.20993514358997345,
-0.32518470287323,
0.2066376805305481,
0.416210412979126,
-0.10419849306344986,
0.4357236921787262,
-0.07763110846281052,
-0.2608661949634552,
0.1891743689775467,
0.1757391095161438,
0.2922930121421814,
-0.4555455148220062,
-0.12316328287124634,
0.2289823740720749,
-0.35445281863212585,
-0.22059917449951172,
0.37248682975769043,
-0.3993988037109375,
0.17341195046901703,
0.29317954182624817,
0.04486650601029396,
-0.012943140231072903,
-0.020419782027602196,
-0.11225160211324692,
-0.2211853414773941,
-0.5386953353881836,
-0.3450448215007782,
-0.1775338351726532,
-0.13313651084899902,
-0.26057446002960205,
-0.1543274074792862,
-0.16849322617053986,
-0.09424088895320892,
-0.5068113207817078,
0.1066025048494339,
-0.3995378613471985,
0.659459114074707,
0.5287598371505737,
0.5162678360939026,
-0.06379152089357376,
-0.604305624961853,
0.13569582998752594,
-0.3185931146144867,
0.3631257712841034,
-0.5765008926391602,
-0.7876835465431213,
0.2575105130672455,
0.014468647539615631,
0.033833976835012436,
-0.5637267231941223,
-0.08403623849153519,
-0.010822881013154984,
-0.36421358585357666,
-0.45351317524909973,
-0.17590662837028503,
-0.22565719485282898,
-0.4180888235569,
-0.28957778215408325,
0.08292144536972046,
0.08497592806816101,
-0.08987189084291458,
0.39264795184135437,
-0.0757824182510376,
-0.37029364705085754,
-0.45358848571777344,
0.4921502470970154,
0.4083811640739441,
-0.38925182819366455,
0.28411030769348145,
0.051471393555402756,
0.2753754258155823,
0.29621994495391846,
-0.0014007043791934848,
0.06426525861024857,
0.6008970737457275,
0.14247870445251465,
0.2386711835861206,
0.1007695198059082,
-0.646856427192688,
0.32186269760131836,
-0.3319874405860901,
-0.5659748315811157,
0.4930495321750641,
-0.21940138936042786,
0.30427286028862,
0.9164432287216187,
0.6368748545646667,
-0.042853858321905136,
-0.5126286149024963,
0.7698070406913757,
-0.11973118782043457,
0.5795998573303223,
-0.31186115741729736,
0.11924012750387192,
0.5574401617050171,
0.8137742280960083,
-0.1789655089378357,
0.2979051470756531,
-0.18831999599933624,
0.4061032831668854,
0.4781249761581421,
-0.7600710391998291,
-0.3518206477165222,
-0.008140805177390575,
0.8203334808349609,
0.5294215083122253,
0.19131937623023987,
-0.2546220123767853,
-0.0755511149764061,
0.22234675288200378,
-0.010374531149864197,
0.03633282333612442,
0.2879738509654999,
0.29092860221862793,
0.08020356297492981,
-0.122493214905262,
0.04684273898601532,
0.3168712556362152,
-0.0614342987537384,
-0.04571717977523804,
0.1955910176038742,
-0.023080112412571907,
-0.7173311710357666,
-0.02408428117632866,
0.4541483521461487,
0.005167573690414429,
-0.0769282802939415,
0.24130955338478088,
-0.01059865765273571,
0.050774987787008286,
0.371656209230423,
0.1516411155462265,
-0.13424639403820038,
-0.2756807804107666,
0.16039197146892548,
-0.33562326431274414,
-0.20107950270175934,
0.10335681587457657,
0.42274996638298035,
-0.44137057662010193,
-0.03266019746661186,
0.177447110414505,
-0.03841669112443924,
0.5818519592285156,
-0.44069424271583557,
0.09647524356842041,
-0.08191943168640137,
-0.3718046545982361,
0.0826200395822525,
-0.16268442571163177,
-0.29108551144599915,
0.15880697965621948,
0.13370338082313538,
0.07775852829217911,
0.1756647229194641,
-0.4782507121562958,
0.24548384547233582,
0.2754419445991516,
-0.1410425901412964,
-0.1894112378358841,
0.14847590029239655,
0.25010406970977783,
0.14955884218215942,
-0.09573160111904144,
-0.022352401167154312,
-0.2024756371974945,
-0.50245600938797,
0.1826731562614441,
-0.10944880545139313,
0.625485360622406,
-0.4365873336791992,
0.07433104515075684,
-0.6312801241874695,
0.10084627568721771,
0.4321590065956116,
-0.07055246084928513,
-0.372915655374527,
-0.03126141428947449,
-0.1365664303302765,
0.002258526161313057,
0.39634403586387634,
-0.25969359278678894,
-0.3552062213420868,
-0.29117074608802795,
-0.5331863760948181,
-0.5763131380081177,
0.41674691438674927,
-0.22632421553134918,
0.05760252848267555,
-0.1066194474697113,
0.5341856479644775,
0.7317884564399719,
-0.15525197982788086,
0.39236122369766235,
-0.1184321865439415,
-0.47562968730926514,
-0.6489065885543823,
0.4425380229949951,
-0.46371984481811523,
0.24278369545936584,
0.09810345619916916,
0.5540302991867065,
0.5282647013664246,
-0.2702995836734772,
0.20752324163913727,
-0.36796891689300537,
0.34182220697402954,
0.03282321244478226,
0.15525875985622406,
0.4772927165031433,
0.25920501351356506,
-0.2873343825340271,
-0.5671724081039429,
0.31779181957244873,
-0.3320029079914093,
-0.4055343270301819,
-0.13313616812229156,
-0.05006703361868858,
-0.3072532117366791,
0.21160118281841278,
0.11809948086738586,
-0.5219897031784058,
-0.23294992744922638,
-0.25603100657463074
] |
BACKGROUND: Study of drug-target interaction networks is an important topic for drug development. It is both time-consuming and costly to determine compound-protein interactions or potential drug-target interactions by experiments alone. As a complement, the in silico prediction methods can provide us with very useful information in a timely manner. METHODS/PRINCIPAL FINDINGS: To realize this, drug compounds are encoded with functional groups and proteins encoded by biological features including biochemical and physicochemical properties. The optimal feature selection procedures are adopted by means of the mRMR (Maximum Relevance Minimum Redundancy) method. Instead of classifying the proteins as a whole family, target proteins are divided into four groups: enzymes, ion channels, G-protein- coupled receptors and nuclear receptors. Thus, four independent predictors are established using the Nearest Neighbor algorithm as their operation engine, with each to predict the interactions between drugs and one of the four protein groups. As a result, the overall success rates by the jackknife cross-validation tests achieved with the four predictors are 85.48%, 80.78%, 78.49%, and 85.66%, respectively. CONCLUSION/SIGNIFICANCE: Our results indicate that the network prediction system thus established is quite promising and encouraging. | [
0.0089698676019907,
0.0067084189504384995,
-0.009476234205067158,
0.009616317227482796,
-0.009072020649909973,
-0.0075616310350596905,
0.009197859093546867,
0.015344795770943165,
-0.012054495513439178,
-0.007298722863197327,
-0.0006737112998962402,
0.004956247750669718,
0.004517403431236744,
0.011863118037581444,
-0.0028844622429460287,
-0.0024666888639330864,
-0.008041005581617355,
-0.004443065263330936,
0.0029273885302245617,
-0.0018330281600356102,
0.018483422696590424,
0.0018093744292855263,
0.009555011987686157,
0.010898256674408913,
-0.01666688546538353,
0.002750466577708721,
-0.006019399501383305,
-0.017629820853471756,
-0.010547082871198654,
-0.011045306921005249,
0.008089074864983559,
-0.0003761238185688853,
0.02718830667436123,
0.021091274917125702,
0.009550414979457855,
-0.009988151490688324,
0.0019032210111618042,
0.006588662974536419,
0.033299319446086884,
-0.00403076596558094,
0.0014289276441559196,
-0.0080413818359375,
0.0004051009891554713,
-0.004525268450379372,
-0.008499659597873688,
-0.005808268673717976,
-0.003760548308491707,
0.025992970913648605,
-0.0021424542646855116,
0.006979462690651417,
-0.009094083681702614,
0.016918044537305832,
-0.002700003795325756,
0.006759302224963903,
-0.005446058697998524,
-0.02862534485757351,
0.01805013418197632,
-0.00899430364370346,
-0.025329500436782837,
-0.006829091813415289,
0.021883409470319748,
0.010816998779773712,
0.01148111093789339,
-0.0026113963685929775,
0.0029017438646405935,
-0.06758586317300797,
-0.010515628382563591,
0.016867104917764664,
0.013641759753227234,
0.017425455152988434,
-0.0003451678203418851,
0.015832018107175827,
-0.017815284430980682,
-0.013875982724130154,
0.0005372688174247742,
-0.0024679601192474365,
-0.002063847379758954,
0.013373211026191711,
0.009170539677143097,
0.005548571702092886,
-0.02822228893637657,
0.0042533851228654385,
0.012723159976303577,
0.020502561703324318,
0.0059493351727724075,
0.011064063757658005,
-0.00666460208594799,
0.021262802183628082,
0.009050266817212105,
0.006401656195521355,
0.002980930730700493,
-0.002419582102447748,
0.009355338290333748,
0.005660452414304018,
-0.002554967999458313,
-0.020755212754011154,
-0.005040684249252081,
0.02738669514656067,
0.01705343835055828,
0.014261359348893166,
-0.017788177356123924,
-0.012305407784879208,
0.021383823826909065,
0.005263928789645433,
0.002395701827481389,
0.009398065507411957,
-0.030311577022075653,
0.03391849249601364,
-0.015218203887343407,
0.006586805917322636,
-0.003187293652445078,
0.017104601487517357,
0.0005509457550942898,
-0.01035584881901741,
-0.0008101477287709713,
0.007913539186120033,
0.005771700292825699,
0.0030352696776390076,
0.012492095120251179,
0.02101476863026619,
0.018841272220015526,
0.01185633335262537,
0.0003223076928406954,
0.0008591590449213982,
0.0057905130088329315,
-0.025357358157634735,
-0.012729005888104439,
-0.003767949528992176,
0.018727639690041542,
0.0029034866020083427,
-0.008186062797904015,
0.002493176842108369,
0.01849387399852276,
-0.00303379213437438,
-0.0025339790154248476,
-0.00712568499147892,
-0.010354114696383476,
-0.00898278970271349,
0.005185255315154791,
-0.0096344705671072,
-0.002145219361409545,
0.008467132225632668,
0.0038034680765122175,
0.02102329581975937,
0.004258773289620876,
0.0029461802914738655,
0.000019954517483711243,
-0.0025273612700402737,
0.0005024764686822891,
0.005305108148604631,
0.004499228671193123,
-0.006152993533760309,
-0.012071987614035606,
-0.021246392279863358,
0.019502293318510056,
0.007682629860937595,
0.0025744347367435694,
0.007423947565257549,
-0.007889876142144203,
-0.036316148936748505,
-0.0028617866337299347,
0.0014951492194086313,
-0.0033641343470662832,
0.007773168385028839,
0.021422505378723145,
0.005309583619236946,
0.006306673400104046,
0.0019964585080742836,
-0.02403479442000389,
0.002950152847915888,
-0.007469080854207277,
-0.0020336173474788666,
-0.004784715361893177,
0.0071011753752827644,
-0.020096449181437492,
0.008291980251669884,
-0.0010878420434892178,
0.008647989481687546,
-0.01922496408224106,
0.06708016991615295,
0.030891604721546173,
0.014405220746994019,
0.009810328483581543,
-0.003715718165040016,
-0.0070158387534320354,
-0.00589459203183651,
0.008762679062783718,
-0.004031218588352203,
-0.0011912202462553978,
-0.011224286630749702,
0.004702898673713207,
-0.013468792662024498,
-0.0003298071678727865,
-0.022559262812137604,
-0.015649622306227684,
0.002710849978029728,
0.012609036639332771,
0.005911401938647032,
0.0041670119389891624,
-0.033175259828567505,
0.027415264397859573,
-0.002179676666855812,
0.010580762289464474,
0.0046183825470507145,
-0.028835324570536613,
-0.0020100439433008432,
-0.014186238870024681,
-0.019448690116405487,
-0.01782534457743168,
-0.0018226644024252892,
0.014692701399326324,
-0.02677902765572071,
-0.0017418512143194675,
-0.003257990349084139,
0.011439921334385872,
0.006991718430072069,
0.0035719010047614574,
0.005450869910418987,
-0.004479566123336554,
-0.012455830350518227,
-0.0014307111268863082,
0.0017434773035347462,
0.009420506656169891,
-0.026736242696642876,
0.009527117013931274,
-0.015329748392105103,
-0.005190703086555004,
0.01159437745809555,
-0.008483828976750374,
0.000030589173547923565,
-0.006715921685099602,
0.00011209119111299515,
-0.0097426138818264,
-0.03859031945466995,
0.012077326886355877,
-0.002518384251743555,
0.010366523638367653,
0.005918227136135101,
0.001040279516018927,
-0.007443523034453392,
-0.013333217240869999,
-0.004468901082873344,
0.014842018485069275,
-0.01658652350306511,
0.01404307596385479,
-0.020151179283857346,
-0.009794514626264572,
0.0009832624346017838,
-0.03160102665424347,
0.008200572803616524,
0.006057212129235268,
0.007710013538599014,
0.037165869027376175,
-0.008073104545474052,
-0.007011469453573227,
0.013623123988509178,
-0.000672817463055253,
-0.0031576515175402164,
0.02084791660308838,
-0.024131348356604576,
-0.0004759981529787183,
0.007182876113802195,
0.007902659475803375,
-0.003368545323610306,
0.001983859110623598,
0.011434699408710003,
0.023931529372930527,
0.0006777895614504814,
-0.006704852916300297,
-0.01984298974275589,
0.004317746497690678,
-0.00871702004224062,
-0.00849917158484459,
-0.0814591646194458,
-0.008043165318667889,
-0.022739458829164505,
0.0068628257140517235,
0.013437362387776375,
-0.013113211840391159,
-0.006159466691315174,
0.00007241172716021538,
-0.002741732634603977,
0.0052720485255122185,
0.005650175269693136,
0.008674586191773415,
-0.005928272381424904,
0.00535571901127696,
0.01701456680893898,
-0.011219545267522335,
0.009255493059754372,
0.012405679561197758,
0.016657549887895584,
-0.0011136513203382492,
-0.0027738967910408974,
-0.009081058204174042,
-0.004288265481591225,
0.005893426015973091,
-0.0120469368994236,
0.03373038023710251,
-0.00346466270275414,
0.006349165458232164,
0.00038255611434578896,
0.0052293757908046246,
0.005027433857321739,
0.0010061678476631641,
0.0015272265300154686,
-0.037706926465034485,
0.02627706713974476,
0.01765170693397522,
0.005952593870460987,
0.0053404755890369415,
-0.009967817924916744,
0.006348888389766216,
0.0005351814907044172,
0.011678754352033138,
-0.006961991544812918,
0.001235684147104621,
0.0011741947382688522,
0.010660283267498016,
-0.0036377704236656427,
0.01035937387496233,
0.008507460355758667,
0.011928717605769634,
0.012392733246088028,
-0.005451885983347893,
0.0031361845321953297,
0.015618352219462395,
-0.00640984158962965,
0.017812665551900864,
-0.007915790192782879,
0.005910032894462347,
-0.013828817754983902,
-0.008420910686254501,
-0.013880633749067783,
0.006117738783359528,
0.002924041822552681,
-0.010431819595396519,
-0.0030870442278683186,
-0.029881469905376434,
0.008118423633277416,
0.005708710290491581,
-0.009038697928190231,
0.011817056685686111,
0.031219415366649628,
-0.00448784651234746,
-0.02932725101709366,
0.00392846018075943,
0.01371037494391203,
-0.009483381174504757,
-0.01380955334752798,
-0.00835120864212513,
-0.010465327650308609,
-0.03397242724895477,
0.011737607419490814,
0.004484172910451889,
0.011650403961539268,
-0.011117810383439064,
-0.012430690228939056,
-0.020864346995949745,
0.0040402719751000404,
0.002685793209820986,
0.002804834395647049,
-0.011972558684647083,
0.0032214364036917686,
0.00884433463215828,
-0.012510123662650585,
0.00633569061756134,
0.005024188198149204,
-0.025928620249032974,
-0.005536624696105719,
0.019038043916225433,
0.014497867785394192,
0.009587742388248444,
-0.005155007354915142,
-0.007210269570350647,
-0.02622479945421219,
-0.014275497756898403,
-0.017529761418700218,
0.008014664053916931,
-0.012186671607196331,
0.008138264529407024,
0.0019466737285256386,
-0.00980079360306263,
-0.022907163947820663,
-0.009624804370105267,
-0.00751812057569623,
0.013244465924799442,
0.002894494216889143,
0.008961175568401814,
-0.019105985760688782,
0.015129456296563148,
0.07328534126281738,
0.02358369529247284,
0.00558240944519639,
-0.008388803340494633,
-0.009475396946072578,
-0.017973320558667183,
0.007441600318998098,
0.009857026860117912,
0.029258515685796738,
-0.019750718027353287,
0.009484685957431793,
0.010890783742070198,
-0.0025708226021379232,
0.01733533665537834,
-0.006866397336125374,
0.0054369159042835236,
-0.027308739721775055,
0.005226334556937218,
0.00008000875823199749,
0.002725807949900627,
-0.0034562409855425358,
-0.0281363558024168,
0.008435755036771297,
-0.014470860362052917,
-0.0012900157598778605,
-0.008304648101329803,
0.004443850833922625,
-0.01245555467903614,
-0.012904077768325806,
0.005416860803961754,
0.009093986824154854,
0.0010623380076140165,
-0.005447977222502232,
-0.012984851375222206,
-0.001001027412712574,
0.022646673023700714,
0.01743808016180992,
0.01047799177467823,
-0.020018815994262695,
-0.00024330615997314453,
-0.0028648085426539183,
-0.015649307519197464,
0.017206300050020218,
0.012391089461743832,
-0.00889044813811779,
-0.007596699055284262,
-0.013286910951137543,
-0.0043772198259830475,
-0.0027464190497994423,
0.004271955229341984,
-0.007634805049747229,
0.0013003934873268008,
0.005611882079392672,
0.02194841206073761,
0.006607976742088795,
0.0006497919093817472,
-0.0027055758982896805,
0.008295890875160694,
0.007760398089885712,
-0.023383483290672302,
-0.03897334635257721,
-0.00814465805888176,
0.011491728015244007,
-0.020243851467967033,
0.017499713227152824,
-0.017567161470651627,
0.014296207576990128,
-0.004264485090970993,
-0.009215157479047775,
0.018781913444399834,
0.00169361662119627,
-0.0024835513904690742,
0.005322447046637535,
-0.010109618306159973,
-0.007561772596091032,
-0.033685099333524704,
0.0063888151198625565,
-0.021522335708141327,
-0.0034519806504249573,
-0.022571302950382233,
-0.00344596104696393,
0.017702138051390648,
0.010864732787013054,
-0.015388697385787964,
-0.00709148496389389,
0.023595348000526428,
-0.02513168379664421,
-0.07494069635868073,
-0.028889397159218788,
-0.001947319833561778,
-0.002371913054957986,
-0.026282351464033127,
0.03600028529763222,
0.003770562820136547,
0.003517948091030121,
0.009840930812060833,
-0.010886693373322487,
-0.0034765838645398617,
-0.013326939195394516,
-0.015064449980854988,
-0.0005694478750228882,
0.009632384404540062,
-0.0026326444931328297,
-0.01068422757089138,
0.00005049904575571418,
0.002701152814552188,
0.004534976556897163,
-0.016013188287615776,
-0.007420378737151623,
-0.024958636611700058,
0.00016358483117073774,
0.0033763661049306393,
-0.08195015788078308,
-0.016086088493466377,
-0.00027853716164827347,
-0.014310856349766254,
-0.012585524469614029,
-0.022173814475536346,
0.00795314647257328,
-0.0111058559268713,
-0.009385751560330391,
-0.012131250463426113,
0.020174456760287285,
0.0021651899442076683,
-0.014196829870343208,
-0.009858827106654644,
0.01768430694937706,
-0.00030603943741880357,
0.00021389592438936234,
-0.015779633074998856,
0.030266612768173218,
-0.013883962295949459,
-0.005998994689434767,
0.01997847855091095,
-0.011182483285665512,
0.013784965500235558,
-0.006767179351300001,
-0.02941819094121456,
-0.005120149813592434,
0.012894749641418457,
-0.006508885882794857,
-0.0373472198843956,
-0.007076565641909838,
-0.006333986297249794,
-0.015583666041493416,
-0.019559934735298157,
0.014032861217856407,
-0.008976848796010017,
-0.026453079655766487,
0.001904575154185295,
0.01787429116666317,
-0.016002699732780457,
-0.009715409949421883,
0.005032357759773731,
-0.0065457783639431,
-0.012163303792476654,
0.0258566215634346,
-0.009663327597081661,
0.005448350682854652,
-0.0016414911951869726,
0.012332258746027946,
0.004779170732945204,
0.01110588014125824,
-0.008998631499707699,
0.007663381285965443,
0.012749379500746727,
0.0017279412131756544,
0.006219059228897095,
-0.007965036667883396,
-0.005031577777117491,
-0.0014646467752754688,
0.012011464685201645,
-0.004947488661855459,
0.004742788150906563,
-0.002654371317476034,
0.07226654887199402,
-0.03870633989572525,
0.010170964524149895,
-0.024414941668510437,
-0.004884006921201944,
-0.0005608015926554799,
0.04458265379071236,
-0.014943811111152172,
0.0027999517042189837,
-0.021109675988554955,
0.005511012859642506,
-0.011624446138739586,
-0.006886129267513752,
0.008799923583865166,
0.004661346320062876,
-0.021144649013876915,
-0.005727355368435383,
-0.003537496319040656,
0.004695886746048927,
0.010722070932388306,
-0.019042417407035828,
0.0008543117437511683,
-0.027333438396453857,
0.019460074603557587,
0.023535583168268204,
-0.0039797318167984486,
0.0009701387025415897,
-0.0007859873585402966,
-0.008526364341378212,
0.009476138278841972,
-0.007148916833102703,
0.0067688338458538055,
-0.0005354583263397217,
0.005002477206289768,
-0.0020706956274807453,
0.013282151892781258,
0.009840158745646477,
-0.0015128287486732006,
-0.001698801526799798,
0.011065220460295677,
-0.0031796484254300594,
0.003720296546816826,
0.0009147783275693655,
-0.0090500982478261,
0.01216538343578577,
-0.0004403805360198021,
-0.0018827533349394798,
0.009037668816745281,
0.03455733507871628,
0.007857294753193855,
0.014271954074501991,
-0.0018793597118929029,
0.0033827945590019226,
0.013098860159516335,
-0.0008562421426177025,
-0.014213228598237038,
-0.008960418403148651,
0.011492425575852394,
0.0026809200644493103,
-0.03101535513997078,
0.010481355711817741,
-0.020258614793419838,
0.003712963778525591,
-0.00871206820011139,
0.03240588307380676,
-0.005454563535749912,
-0.005487358197569847,
-0.009674189612269402,
-0.005307414103299379,
0.0134764164686203,
-0.02464541420340538,
0.010908015072345734,
0.0050328997895121574,
0.00952892191708088,
0.006181628443300724,
0.013568523339927197,
0.037949346005916595,
-0.012109077535569668,
0.02063228189945221,
-0.003703723894432187,
-0.012536589056253433,
0.0016324492171406746,
0.01299353502690792,
-0.006213482469320297,
-0.00882217101752758,
0.022555220872163773,
-0.004431526642292738,
-0.005642831791192293,
-0.002208614954724908,
0.011208482086658478,
0.01924334466457367,
0.004918842576444149,
0.003493697615340352,
-0.0038574691861867905,
0.007490881718695164,
0.03260494023561478,
0.03620659559965134,
0.0015991984400898218,
-0.005122739356011152,
0.006652109324932098,
0.01972273364663124,
0.007104754447937012,
0.0036558646243065596,
-0.0060100010596215725,
0.0006862804293632507,
-0.004293529782444239,
0.005850896704941988,
-0.024364836513996124,
0.029378056526184082,
0.003998968750238419,
-0.011409608647227287,
0.004722813609987497,
0.004466822370886803,
0.015432306565344334,
0.018829111009836197,
0.02082962542772293,
0.0003121396293863654,
-0.008000547997653484,
-0.011739813722670078,
-0.008620758540928364,
-0.016074107959866524,
0.005912899039685726,
-0.01766153797507286,
0.015127518214285374,
0.0022942698560655117,
-0.029214823618531227,
-0.004555693827569485,
0.014930462464690208,
0.018202491104602814,
0.010526715777814388,
0.009417103603482246,
0.00037275394424796104,
-0.013680261559784412,
-0.006850536447018385,
0.007058035582304001,
0.03201242536306381,
-0.0003148689866065979,
0.006521813105791807,
0.007575288414955139,
-0.04360756278038025,
0.007959291338920593,
-0.010697800666093826,
-0.004370716400444508,
-0.008839315734803677,
0.00790029764175415,
-0.01604180783033371,
0.004699191078543663,
0.03009643219411373,
0.0070500983856618404,
0.019204121083021164,
-0.0034544854424893856,
0.0159154012799263,
-0.002289786469191313,
-0.0034641223028302193,
-0.010032093152403831,
0.024017758667469025,
0.0025667105801403522,
-0.01730520650744438,
-0.013557243160903454,
-0.0035729743540287018,
-0.010738179087638855,
-0.008815200999379158,
-0.013094941154122353,
-0.005247647874057293,
-0.01393147837370634,
0.012553428299725056,
-0.016373801976442337,
0.027044551447033882,
-0.014153244905173779,
-0.0019308940973132849,
0.0013059604680165648,
0.0018361967522650957,
0.02162027731537819,
0.014344410970807076,
-0.02119974046945572,
-0.01261816918849945,
-0.010502479039132595,
0.0018946805503219366,
-0.02008879743516445,
0.02134372666478157,
0.028517087921500206,
0.017673250287771225,
-0.0018948568031191826,
-0.009635968133807182,
-0.0015367763116955757,
0.013219829648733139,
-0.0010881898924708366,
-0.018386468291282654,
-0.0009916762355715036,
0.004908915609121323,
-0.006020821630954742,
-0.012366531416773796,
-0.02521420270204544,
0.010241508483886719,
-0.017910141497850418,
-0.01307850331068039,
0.011737100780010223,
-0.026984959840774536,
0.007829324342310429,
0.012041451409459114,
-0.0027676871977746487,
-0.017093617469072342
] | [
0.37317731976509094,
0.21815115213394165,
0.1274535357952118,
0.05539654940366745,
0.2647560238838196,
-0.014858548529446125,
-0.25422659516334534,
-0.28644832968711853,
-0.1593819111585617,
-0.5415350198745728,
0.04588077589869499,
0.4316210448741913,
-0.3284873068332672,
0.24752523005008698,
-0.1464981883764267,
0.8256732821464539,
0.7207409739494324,
0.3856605291366577,
0.007063000928610563,
-0.2625040113925934,
-0.3043067455291748,
0.14889663457870483,
0.33362436294555664,
-0.23033097386360168,
0.3633884787559509,
0.058769505470991135,
0.5156860947608948,
0.32126954197883606,
0.34605202078819275,
-0.040785133838653564,
-0.18808183073997498,
0.09931299090385437,
-0.26708778738975525,
0.15832260251045227,
0.03761490061879158,
-0.07102374732494354,
-0.13672930002212524,
0.35998815298080444,
0.06651048362255096,
-0.4256848096847534,
-0.19448253512382507,
-0.32169485092163086,
-0.4730663597583771,
0.3779630959033966,
-0.42384347319602966,
-0.7902441620826721,
-1.2473528385162354,
0.3272327184677124,
-0.5104965567588806,
-0.227386936545372,
0.3652377128601074,
0.5813281536102295,
0.16048792004585266,
0.14852799475193024,
0.13735629618167877,
0.24005037546157837,
-0.41068893671035767,
-0.3902716636657715,
0.35599154233932495,
-0.5310980677604675,
0.17894607782363892,
-0.022970059886574745,
-0.14177733659744263,
0.3760855495929718,
-0.08588749915361404,
0.6486132144927979,
0.13911092281341553,
-0.4905988872051239,
-0.5165879130363464,
-0.1911025494337082,
0.3781842291355133,
-0.21360209584236145,
-0.3052268326282501,
0.09673617035150528,
-0.3755536675453186,
0.24568696320056915,
0.020532364025712013,
0.009333869442343712,
0.02990095317363739,
-0.25114721059799194,
-0.016869809478521347,
-0.16370736062526703,
0.015990938991308212,
-0.27605196833610535,
0.5147022008895874,
0.31403398513793945,
-0.20506368577480316,
0.3463089168071747,
-0.528632402420044,
-0.051784269511699677,
-0.037832554429769516,
-0.11393383145332336,
0.08844682574272156,
0.7641852498054504,
0.41427192091941833,
0.02201198600232601,
0.10573339462280273,
-0.0607013963162899,
0.12900790572166443,
0.42038601636886597,
-0.24461893737316132,
-0.1262107640504837,
0.07034347951412201,
-0.12131861597299576,
-0.46609365940093994,
-0.2725079655647278,
-0.2153318077325821,
-0.20818142592906952,
-1.104799747467041,
0.21467173099517822,
-0.5840251445770264,
0.039952442049980164,
-0.21570514142513275,
-0.058821506798267365,
-0.43034157156944275,
-0.06984710693359375,
-0.06026681140065193,
-0.1551152914762497,
-0.26466450095176697,
0.5375432372093201,
-0.21316677331924438,
1.1158485412597656,
-0.16135410964488983,
0.3866540491580963,
0.3413842022418976,
0.21979698538780212,
0.44898444414138794,
0.3230490982532501,
-0.3533107042312622,
0.7358485460281372,
0.28889819979667664,
0.6378793120384216,
-0.3047082722187042,
0.3399236798286438,
-0.244131401181221,
-0.1665019541978836,
0.6111533641815186,
0.2195912003517151,
0.23010997474193573,
-0.07243023067712784,
-0.5419490933418274,
-0.9142621755599976,
-0.05400639772415161,
-0.10905435681343079,
-0.03136571869254112,
-0.9415703415870667,
-0.0630113035440445,
-0.4179498851299286,
-0.3715759217739105,
-0.07910950481891632,
0.21951335668563843,
-0.22914361953735352,
-0.6285495758056641,
-0.27895689010620117,
-0.03926856443285942,
0.7219995856285095,
-0.017092259600758553,
0.2381715327501297,
-0.5193207263946533,
0.33658766746520996,
0.2640141248703003,
0.17268377542495728,
-0.6822118759155273,
-0.4176572263240814,
0.4913128912448883,
-0.19842644035816193,
0.33632445335388184,
0.3071054220199585,
0.144915372133255,
0.09237509220838547,
-0.07649936527013779,
-0.5710366368293762,
0.0022619871888309717,
-0.8217225074768066,
-0.10025399923324585,
0.15772682428359985,
-0.07384760677814484,
-0.1936655044555664,
0.04706095904111862,
-0.06338291615247726,
-0.6054785847663879,
-0.11781440675258636,
-0.26244157552719116,
-0.9092617630958557,
0.2290535271167755,
-0.15872448682785034,
0.569776177406311,
0.035012464970350266,
-0.39688563346862793,
-0.2424938827753067,
-0.5221045017242432,
-0.18034130334854126,
0.6862292289733887,
-0.9364034533500671,
1.731858730316162,
-0.5031772255897522,
0.05017959326505661,
1.3752328157424927,
-0.28216052055358887,
0.2075536698102951,
-0.0798063650727272,
0.20812661945819855,
0.34403690695762634,
-0.4671531915664673,
-0.5333380699157715,
-0.2723786234855652,
0.2089533507823944,
-0.3619915843009949,
-0.047484781593084335,
-0.11794467270374298,
0.8444163799285889,
-0.22129113972187042,
-0.324177086353302,
-0.3016216456890106,
0.4764400124549866,
-0.25033870339393616,
-0.1448240727186203,
0.3050919473171234,
-0.24817299842834473,
0.10184872895479202,
0.47292834520339966,
-0.7270859479904175,
0.34079042077064514,
0.6857743859291077,
-0.2908761501312256,
0.4921379089355469,
0.35126587748527527,
0.21291178464889526,
0.8898072242736816,
-0.37262165546417236,
0.45688360929489136,
-0.4293311536312103,
0.5477057695388794,
-0.8354018330574036,
-0.7761843204498291,
0.007394193205982447,
0.02544248104095459,
0.5908080339431763,
-0.00935240089893341,
-0.1971811056137085,
-0.21029049158096313,
0.4643022418022156,
-0.8685643076896667,
-0.41616442799568176,
-0.3042663037776947,
-0.7907167077064514,
-0.4200015068054199,
-0.17026206851005554,
-0.7657118439674377,
-0.2126854658126831,
-0.06787066906690598,
0.4681413173675537,
0.16656580567359924,
-0.7053104639053345,
0.284183531999588,
0.1705044060945511,
-0.16111108660697937,
-0.2030559629201889,
-0.07087903469800949,
-0.2837717533111572,
-0.11881733685731888,
0.1227121651172638,
0.2245350182056427,
0.021768983453512192,
-0.3126162886619568,
-0.13726891577243805,
-0.06262320280075073,
-0.6842369437217712,
0.8180372714996338,
1.0673246383666992,
0.36895495653152466,
-0.07759851962327957,
-0.47198036313056946,
0.08059611171483994,
0.14900368452072144,
-0.8672863245010376,
0.5990486145019531,
0.7155760526657104,
-0.3419184982776642,
-0.5046818256378174,
-0.04515877366065979,
0.1810941845178604,
1.0898327827453613,
-0.38664549589157104,
-0.2948353588581085,
-0.7222880125045776,
-0.06801720708608627,
-0.0029676505364477634,
-0.26686084270477295,
0.4152030646800995,
-0.4002637267112732,
0.4136938154697418,
-0.4290753901004791,
-0.5537828803062439,
0.29875651001930237,
0.7182345390319824,
-0.13984715938568115,
0.3783032298088074,
0.7259419560432434,
-0.0414186455309391,
-0.0805884450674057,
0.31042367219924927,
-0.1216811016201973,
-0.04091131314635277,
0.1649298071861267,
-0.056755319237709045,
-0.6583938002586365,
0.5996800661087036,
-5.684322357177734,
-0.2162409871816635,
-0.1815606951713562,
-0.1577485352754593,
-0.06149598956108093,
0.1778174638748169,
1.1870797872543335,
0.22241654992103577,
0.6352922320365906,
-0.5196536183357239,
0.15414327383041382,
-0.007365189027041197,
0.025869103148579597,
0.24216613173484802,
0.15833282470703125,
0.07234147191047668,
0.4704599678516388,
0.03114645555615425,
0.6789959669113159,
0.44155678153038025,
0.19092890620231628,
-0.33905741572380066,
0.0419929176568985,
0.5324845314025879,
0.05431017279624939,
0.5312910676002502,
-1.404505729675293,
0.4032703936100006,
-0.08401311933994293,
-0.15367333590984344,
0.2782410681247711,
-0.6073170304298401,
-0.3001852333545685,
-0.6103255152702332,
0.29748064279556274,
0.06295770406723022,
-0.03720109537243843,
-0.247167706489563,
0.11434923112392426,
-0.20959115028381348,
0.6663877367973328,
0.6931350827217102,
-0.39385315775871277,
0.004416151903569698,
0.05346756801009178,
-0.0916546955704689,
-0.2950167655944824,
0.13329964876174927,
-0.14745965600013733,
0.974975049495697,
-0.47564998269081116,
-0.13385985791683197,
0.29352888464927673,
0.15684211254119873,
0.4810347259044647,
-0.29451557993888855,
-0.26345932483673096,
-0.049907833337783813,
-0.24382439255714417,
0.34479251503944397,
0.1950148642063141,
-0.5808694362640381,
0.24607622623443604,
-0.7194994688034058,
-0.01116449385881424,
0.39911600947380066,
-0.8128352761268616,
-0.6658090949058533,
-0.11122921854257584,
0.24102912843227386,
-0.36595776677131653,
0.16940878331661224,
-0.16101138293743134,
-0.444039523601532,
0.2900109887123108,
0.14203718304634094,
0.29657113552093506,
-0.03444618731737137,
0.13547538220882416,
-0.08592119812965393,
-0.03835528343915939,
-0.01166832447052002,
0.386003315448761,
0.027765052393078804,
0.20362447202205658,
-0.3776629567146301,
-0.4501922130584717,
-0.18106068670749664,
-0.5237259268760681,
0.2440163791179657,
0.5888266563415527,
-0.34592577815055847,
0.18994227051734924,
0.4469922184944153,
0.11129210889339447,
0.2685070335865021,
0.3510182201862335,
0.057092536240816116,
0.4291728734970093,
-0.278139591217041,
1.0101985931396484,
-0.22000429034233093,
-0.38162338733673096,
-1.0520777702331543,
-0.10734135657548904,
0.029712747782468796,
-0.755879282951355,
0.12722650170326233,
0.5117651224136353,
-0.8081556558609009,
-0.29175981879234314,
-0.03528933599591255,
-0.41285574436187744,
0.10748396068811417,
0.7311276197433472,
-0.35716891288757324,
0.028995271772146225,
-0.08531299978494644,
0.3324342370033264,
-0.2706694006919861,
0.10662391781806946,
0.279138445854187,
-0.11016669869422913,
0.4735928177833557,
0.2557346820831299,
-0.8808586597442627,
0.259114533662796,
0.49706020951271057,
-0.2787964940071106,
-0.23288443684577942,
0.44192713499069214,
0.40529683232307434,
-0.5762304663658142,
-0.21667207777500153,
0.3893463611602783,
-0.32429325580596924,
-0.21656744182109833,
0.10392636805772781,
0.43643367290496826,
-0.341513991355896,
0.6796876788139343,
-0.3536502420902252,
0.09001856297254562,
0.3679288625717163,
0.3823334574699402,
-0.18907634913921356,
-0.11926564574241638,
0.28592467308044434,
0.11554275453090668,
-0.04740605503320694,
-0.09219187498092651,
0.3096582293510437,
-0.0033830436877906322,
-0.3759678900241852,
-0.3023669123649597,
-0.016994871199131012,
0.7303091883659363,
-0.024446269497275352,
0.21007153391838074,
-0.21263116598129272,
0.5004081130027771,
0.23738223314285278,
-0.9923917055130005,
0.40071386098861694,
-0.18527862429618835,
-0.34850215911865234,
-0.5041998028755188,
-0.01320805586874485,
0.11914081871509552,
0.359022855758667,
-0.342996746301651,
-0.5385916829109192,
0.07421331107616425,
-0.5003053545951843,
-0.169137105345726,
-0.014643876813352108,
-0.2036089152097702,
0.26548147201538086,
0.08324731886386871,
0.08421286940574646,
0.19072605669498444,
-0.5776809453964233,
-0.2551410496234894,
0.8427786231040955,
1.0357388257980347,
0.7109034061431885,
0.2713516056537628,
-0.08308327198028564,
-0.39407554268836975,
-0.6228132843971252,
0.2613012492656708,
0.022232122719287872,
0.44688618183135986,
-0.13353906571865082,
0.07262581586837769,
-0.2601156234741211,
-0.10903332382440567,
0.5973429679870605,
0.2292938083410263,
-0.37682196497917175,
0.19742581248283386,
0.7210446000099182,
-0.20327326655387878,
0.4018952548503876,
0.19729849696159363,
-0.18467748165130615,
-0.20102931559085846,
0.23792767524719238,
-0.04621213302016258,
-0.17425502836704254,
-0.4230087995529175,
-0.5622856020927429,
-0.04397021606564522,
0.3616437613964081,
-0.38047799468040466,
-0.11453390121459961,
0.4590965509414673,
-0.08437468111515045,
-0.3080940246582031,
0.31216689944267273,
0.3382524847984314,
-0.10062366724014282,
-0.046897586435079575,
0.22728678584098816,
0.06559650599956512,
0.1344841718673706,
0.8728082180023193,
-0.6229042410850525,
-0.2800969183444977,
0.2414025068283081,
-0.5095149874687195,
-0.17939536273479462,
0.42884525656700134,
-0.055794741958379745,
-0.9455384612083435,
-0.5443916320800781,
-0.23389729857444763,
0.11156126856803894,
0.5875512361526489,
0.39399877190589905,
-0.016045305877923965,
0.5278030037879944,
-0.30771028995513916,
-0.757991373538971,
0.15997160971164703,
0.5772604942321777,
0.8853549361228943,
-0.5091438889503479,
-0.46587830781936646,
-0.01335132960230112,
0.36222055554389954,
-0.19999364018440247,
-0.10467947274446487,
-0.0012620718916878104,
0.6931359767913818,
0.5360631942749023,
-0.6518449783325195,
-0.3419255316257477,
-0.1249459981918335,
0.31778332591056824,
-0.23361583054065704,
-0.24449670314788818,
-0.49440255761146545,
-0.8771445751190186,
0.3285785913467407,
-0.31504833698272705,
-0.2894527316093445,
-0.19583655893802643,
0.5078255534172058,
-0.21704503893852234,
-0.0851392075419426,
-0.17712271213531494,
0.5526723861694336,
0.8152533769607544,
-0.36942654848098755,
0.41904154419898987,
-0.3196061849594116,
0.1065462976694107,
-0.26921403408050537,
0.08453812450170517,
-0.6749197244644165,
-0.4184773564338684,
0.2217857986688614,
-0.1944766789674759,
0.5167838931083679,
-0.7428666949272156,
0.24195516109466553,
-0.03368345648050308,
0.18350718915462494,
-0.506563663482666,
-0.29443123936653137,
-0.000840509484987706,
-0.8116458058357239,
-0.30234968662261963,
-0.031125526875257492,
0.30692577362060547,
0.26176315546035767,
0.3078688085079193,
0.35515353083610535,
-0.06930971145629883,
0.010320340283215046,
0.5889535546302795,
0.3638703227043152,
-0.8330071568489075,
0.6308972835540771,
0.3191194534301758,
0.3820757567882538,
0.20583175122737885,
-0.170095756649971,
0.10902924090623856,
0.35267239809036255,
-0.1150393933057785,
0.17712891101837158,
0.04526137560606003,
-0.24999192357063293,
-0.0009464077884331346,
-0.08341498672962189,
-0.4176088869571686,
0.9110416173934937,
0.26367372274398804,
-0.003059804206714034,
0.8106397986412048,
0.677902102470398,
-0.1897897571325302,
-0.3838155269622803,
0.8527590036392212,
-0.04839002341032028,
0.0318191796541214,
-0.299626886844635,
0.43937304615974426,
0.5788360834121704,
0.6617711782455444,
0.10551860928535461,
-0.1447685807943344,
-0.23710691928863525,
0.4436996877193451,
0.6229300498962402,
-0.3483459949493408,
-0.22443710267543793,
-0.056930478662252426,
0.2186516672372818,
0.3002542555332184,
-0.4941907227039337,
-0.2649215757846832,
0.12003262341022491,
0.42186465859413147,
0.26369914412498474,
0.3618815541267395,
-0.11024019122123718,
0.29152002930641174,
0.13516633212566376,
0.05997014418244362,
-0.10207443684339523,
0.289194256067276,
0.05258600786328316,
-0.014795039780437946,
0.45879119634628296,
-0.517063319683075,
-0.5447505712509155,
0.14939893782138824,
-0.0017435766058042645,
0.8231313228607178,
-0.03149605914950371,
0.603273332118988,
-0.8035717606544495,
0.21506427228450775,
0.3663488030433655,
0.46461451053619385,
0.39554429054260254,
-0.39953768253326416,
-0.11443960666656494,
-0.011162403970956802,
-0.09738985449075699,
0.3022004961967468,
-0.12391885370016098,
-0.7413417100906372,
0.45333921909332275,
0.017038479447364807,
-0.26447758078575134,
0.07102713733911514,
0.10725993663072586,
0.0850260853767395,
-0.190585657954216,
-0.3779902756214142,
-0.03437367454171181,
-0.21211650967597961,
-0.34178248047828674,
0.15447363257408142,
0.2529611885547638,
0.016646267846226692,
0.20853635668754578,
-0.9180857539176941,
0.22232459485530853,
-0.18999366462230682,
-0.2748960256576538,
0.19398778676986694,
-0.20105569064617157,
0.9181922078132629,
0.12818771600723267,
-0.2356797754764557,
-0.34524136781692505,
0.047588903456926346,
-0.058003466576337814,
1.0481841564178467,
-0.3209474980831146,
0.3889443576335907,
-0.6104176044464111,
-0.07938855141401291,
-0.6242982149124146,
-0.1260915994644165,
0.501913845539093,
-0.062161386013031006,
-0.3620912730693817,
0.11137054860591888,
0.1308787614107132,
0.009662645868957043,
-0.10877358168363571,
-0.2598020136356354,
0.15709184110164642,
-0.32354825735092163,
0.3809123933315277,
-0.29750487208366394,
0.5685883164405823,
0.18541979789733887,
-0.22971321642398834,
-0.4797302484512329,
0.31720781326293945,
0.9775723218917847,
-0.31964707374572754,
0.008868660777807236,
0.12691041827201843,
-0.5361906290054321,
-0.3309630751609802,
0.7027305364608765,
-0.4187018871307373,
0.236661896109581,
-0.07762277871370316,
0.426343709230423,
0.05910174176096916,
-0.336683452129364,
-0.2939384877681732,
-0.11067119985818863,
0.3717564642429352,
0.29017016291618347,
-0.03838832676410675,
0.2070448249578476,
-0.21932640671730042,
-0.30998578667640686,
-0.8131605982780457,
0.33025258779525757,
-0.1618412435054779,
-0.48193153738975525,
-0.42253023386001587,
0.07926797866821289,
-0.5252750515937805,
0.02997603453695774,
-0.1103404238820076,
-0.661342442035675,
-0.20604009926319122,
-0.5923177599906921
] |
An efficient −1 programmed ribosomal frameshifting (PRF) signal requires an RNA slippery sequence and a downstream RNA stimulator, and the hairpin-type pseudoknot is the most common stimulator. However, a pseudoknot is not sufficient to promote −1 PRF. hTPK-DU177, a pseudoknot derived from human telomerase RNA, shares structural similarities with several −1 PRF pseudoknots and is used to dissect the roles of distinct structural features in the stimulator of −1 PRF. Structure-based mutagenesis on hTPK-DU177 reveals that the −1 PRF efficiency of this stimulator can be modulated by sequential removal of base–triple interactions surrounding the helical junction. Further analysis of the junction-flanking base triples indicates that specific stem–loop interactions and their relative positions to the helical junction play crucial roles for the −1 PRF activity of this pseudoknot. Intriguingly, a bimolecular pseudoknot approach based on hTPK-DU177 reveals that continuing triplex structure spanning the helical junction, lacking one of the loop-closure features embedded in pseudoknot topology, can stimulate −1 PRF. Therefore, the triplex structure is an essential determinant for the DU177 pseudoknot to stimulate −1 PRF. Furthermore, it suggests that −1 PRF, induced by an in-trans RNA via specific base–triple interactions with messenger RNAs, can be a plausible regulatory function for non-coding RNAs. | [
-0.003508872352540493,
0.0030030561611056328,
0.006635717581957579,
0.021850289776921272,
0.01723577082157135,
-0.02009185217320919,
0.009285335429012775,
0.00409742770716548,
-0.011211780831217766,
0.027292145416140556,
-0.023374730721116066,
0.0048658587038517,
-0.002454579807817936,
0.013236569240689278,
-0.025880225002765656,
0.011793549172580242,
-0.013462802395224571,
0.0026639504358172417,
0.014978883787989616,
0.02839992754161358,
0.023867640644311905,
0.004370790906250477,
0.008851196616888046,
0.0030010028276592493,
0.019786249846220016,
-0.00514164287596941,
-0.004078269004821777,
-0.021677758544683456,
0.0032184512820094824,
0.006801671348512173,
0.0066306330263614655,
0.0023474665358662605,
-0.010677695274353027,
0.00954323448240757,
0.0056073847226798534,
0.022319180890917778,
-0.008577253669500351,
0.016250573098659515,
0.060498081147670746,
-0.00406711595132947,
-0.01985839009284973,
-0.007489615119993687,
-0.0000036015408113598824,
-0.012414388358592987,
-0.006796625442802906,
-0.007658766116946936,
0.0036916364915668964,
0.006361424922943115,
-0.02227349579334259,
0.0036332115996629,
-0.017649587243795395,
-0.005464478861540556,
-0.012685631401836872,
0.01532988902181387,
-0.005804761778563261,
-0.020743995904922485,
0.016300588846206665,
0.01240450143814087,
-0.040556225925683975,
-0.019888820126652718,
-0.004225120879709721,
0.016355162486433983,
0.007456601597368717,
-0.0190258901566267,
-0.010099883191287518,
-0.06707532703876495,
0.03868713974952698,
-0.0018748149741441011,
0.008036023937165737,
0.018202276900410652,
0.013700774870812893,
0.012105865404009819,
-0.017177049070596695,
-0.021102435886859894,
-0.0018264430109411478,
-0.007180032320320606,
-0.0025888988748192787,
0.009826586581766605,
-0.019581027328968048,
0.0243969913572073,
-0.004696226678788662,
-0.01692354306578636,
0.017516490072011948,
0.00425544660538435,
-0.010093480348587036,
0.00850385520607233,
-0.01152107398957014,
0.0024325442500412464,
-0.013135725632309914,
0.006417538970708847,
0.01471436396241188,
-0.02346966415643692,
0.002130241133272648,
0.023003727197647095,
0.025604069232940674,
-0.010416441597044468,
0.0011847666464745998,
0.009395672008395195,
0.013473408296704292,
-0.027624335139989853,
-0.023544544354081154,
0.022686799988150597,
0.0183614082634449,
-0.0013908609980717301,
0.0056216116063296795,
0.012711388990283012,
0.036667414009571075,
0.023075520992279053,
0.021533410996198654,
0.008923620916903019,
0.0037318989634513855,
-0.0024280869401991367,
-0.02407633326947689,
-0.029455240815877914,
-0.011856128461658955,
0.01645374298095703,
-0.015371229499578476,
0.01812821812927723,
0.017816441133618355,
0.014805901795625687,
-0.004840120207518339,
-0.003085625357925892,
0.00948611181229353,
0.01558371540158987,
0.01175081916153431,
0.0018042391166090965,
-0.011820416897535324,
-0.001135700847953558,
-0.017093993723392487,
0.0029899021610617638,
-0.012081892229616642,
0.011664116755127907,
-0.03758906573057175,
0.00037964247167110443,
0.007856763899326324,
-0.014767222106456757,
0.02204158343374729,
-0.026442814618349075,
0.006365960463881493,
-0.010976706631481647,
-0.00033156026620417833,
0.003485859138891101,
0.010057875886559486,
0.01976083032786846,
-0.004001343622803688,
0.011682800948619843,
-0.002592387143522501,
0.0041905795224010944,
0.0037597347982227802,
-0.003328117774799466,
0.019589174538850784,
0.00935874879360199,
-0.027804525569081306,
-0.007934441789984703,
-0.003798170480877161,
0.010596085339784622,
-0.022469615563750267,
-0.03151002526283264,
-0.0014676247956231236,
0.001074617961421609,
0.0022600211668759584,
0.004433586727827787,
0.009650751948356628,
0.009178230538964272,
0.00484709907323122,
-0.029664505273103714,
-0.004148935899138451,
0.0023964657448232174,
-0.008717186748981476,
0.003818722441792488,
-0.017583120614290237,
0.07109637558460236,
-0.0013988642022013664,
0.0033729970455169678,
0.012908479198813438,
0.002437497954815626,
-0.002364720217883587,
0.00897238589823246,
-0.019015295431017876,
0.06704878062009811,
-0.011684790253639221,
0.00981229916214943,
0.007692819461226463,
0.009632151573896408,
0.0025091315619647503,
-0.026820307597517967,
0.013129528611898422,
-0.006594895385205746,
0.0214119590818882,
0.007568847853690386,
-0.013159318827092648,
0.006451250985264778,
-0.01397678256034851,
0.025297243148088455,
0.010813895612955093,
0.0025322192814201117,
0.007340859621763229,
0.012112092226743698,
-0.013030572794377804,
0.011552218347787857,
0.02595142275094986,
0.010870126076042652,
0.0401492603123188,
0.011159961111843586,
0.0021935668773949146,
0.009336395189166069,
0.00008547026664018631,
-0.003354636486619711,
-0.014066226780414581,
-0.013130739331245422,
0.017743639647960663,
-0.022861428558826447,
-0.0030771493911743164,
-0.005302807316184044,
0.02328788861632347,
-0.007455233950167894,
-0.022373739629983902,
0.02000974863767624,
0.025514725595712662,
-0.010428505018353462,
-0.003864155150949955,
0.0025694365613162518,
0.014568636193871498,
-0.02768274024128914,
0.007184801157563925,
0.0006806589663028717,
-0.004929798189550638,
0.013329904526472092,
-0.012221280485391617,
-0.0044811805710196495,
0.009448071010410786,
-0.02879435196518898,
-0.013419309630990028,
0.021340664476156235,
0.038694534450769424,
-0.01541082002222538,
0.01231007743626833,
-0.01871989108622074,
0.011477644555270672,
-0.01209354866296053,
-0.0035190628841519356,
0.016559813171625137,
0.031841978430747986,
-0.022489171475172043,
0.0063416482880711555,
-0.01254262775182724,
0.03342586010694504,
0.029620971530675888,
-0.010268939658999443,
-0.011762253008782864,
0.007370534352958202,
-0.006445200182497501,
-0.013420846313238144,
-0.006860608235001564,
0.024147052317857742,
0.0014466089196503162,
0.03271547704935074,
0.019905999302864075,
0.021389372646808624,
-0.020069323480129242,
0.006568199954926968,
0.004168759100139141,
-0.003769586095586419,
-0.012968272902071476,
-0.017062250524759293,
0.006297404412180185,
0.0014722621999680996,
0.012052751146256924,
-0.00514685595408082,
-0.002730431966483593,
0.00991901010274887,
-0.015029512345790863,
-0.010705853812396526,
-0.0814235508441925,
-0.012712370604276657,
-0.0017548305913805962,
-0.0024791378527879715,
0.004903935827314854,
0.005889133550226688,
-0.00018887687474489212,
0.019267534837126732,
-0.019213538616895676,
-0.018432127311825752,
-0.003359908005222678,
0.012036938220262527,
-0.01290943194180727,
0.011341536417603493,
0.018338600173592567,
-0.007136007770895958,
0.021649911999702454,
0.006488210987299681,
-0.006679563317447901,
-0.022225266322493553,
-0.004272475838661194,
-0.01241397950798273,
-0.02659941464662552,
0.011585692875087261,
-0.037806347012519836,
-0.001720634289085865,
0.005864579230546951,
-0.006956654600799084,
-0.012973519042134285,
-0.0016685446025803685,
-0.015271758660674095,
-0.00957176648080349,
0.0162692628800869,
-0.0002867341972887516,
0.05358099192380905,
0.007411805447191,
-0.017314160242676735,
0.008480479940772057,
-0.010687053203582764,
0.024993225932121277,
-0.021406035870313644,
0.003558696247637272,
-0.016977543011307716,
0.00183895044028759,
-0.010134587064385414,
0.02436143159866333,
-0.017744898796081543,
0.012345371767878532,
0.013004718348383904,
-0.01787084899842739,
0.009590446017682552,
-0.00037437258288264275,
-0.003109146375209093,
0.018596166744828224,
-0.011780567467212677,
-0.009657474234700203,
0.01486235298216343,
0.011487599462270737,
-0.013881138525903225,
-0.011795291677117348,
-0.027950633317232132,
0.026596590876579285,
0.026303507387638092,
-0.01843693107366562,
0.023644277825951576,
0.004603836219757795,
0.006838398985564709,
-0.009680480696260929,
-0.010316761210560799,
0.009967062622308731,
0.013838967308402061,
-0.007803730666637421,
-0.007595188450068235,
-0.0062706004828214645,
-0.01546543464064598,
-0.0174250565469265,
-0.013442387804389,
-0.01577938348054886,
0.0012363966088742018,
-0.013838786631822586,
0.002214631997048855,
0.00855151005089283,
-0.009015058167278767,
0.0037547219544649124,
-0.022541459649801254,
0.017313864082098007,
0.004411578178405762,
0.009512404911220074,
0.006075672805309296,
-0.009217817336320877,
0.025442028418183327,
0.01384673174470663,
0.00857685599476099,
0.010912436991930008,
-0.01604488119482994,
-0.012361486442387104,
0.0031734080985188484,
0.01079876720905304,
-0.0032073066104203463,
0.00894424133002758,
-0.01721581257879734,
-0.004075783770531416,
0.019721336662769318,
-0.010751686990261078,
-0.03018571063876152,
0.0111878402531147,
-0.008915496990084648,
0.006364565342664719,
-0.012211483903229237,
-0.0021701951045542955,
0.008500793017446995,
0.010773690417408943,
-0.009835447184741497,
0.028206318616867065,
0.0046266429126262665,
-0.0323343425989151,
-0.007190481293946505,
-0.01219983771443367,
0.0728105902671814,
0.018619127571582794,
0.02111419290304184,
-0.016785165295004845,
-0.005322737153619528,
-0.017807262018322945,
0.005180058069527149,
0.01756499707698822,
0.013996608555316925,
0.006478746887296438,
0.009523212909698486,
-0.01704707369208336,
0.011417130008339882,
-0.004600008483976126,
-0.024922195822000504,
-0.014731701463460922,
-0.033231548964977264,
0.00002751871943473816,
0.004280422814190388,
0.013602573424577713,
0.005445534363389015,
-0.0220294501632452,
0.020982978865504265,
-0.028642557561397552,
-0.013401966542005539,
-0.014831878244876862,
0.01825110986828804,
-0.016393344849348068,
-0.017700105905532837,
0.013270833529531956,
0.007540506310760975,
-0.03867213800549507,
-0.01037096232175827,
-0.00046692771138623357,
0.01911098137497902,
0.001658296212553978,
-0.003350775223225355,
0.0019272998906672,
-0.021414000540971756,
0.01133829914033413,
-0.002390035428106785,
-0.013315207324922085,
-0.0068776425905525684,
0.009601935744285583,
0.006872653495520353,
-0.00271979090757668,
-0.004357420839369297,
-0.01172382291406393,
-0.005741851404309273,
-0.0012080110609531403,
-0.007252264767885208,
-0.0017285069916397333,
0.010376056656241417,
0.0038415491580963135,
0.016471467912197113,
-0.021387746557593346,
0.01322097610682249,
0.0028098823968321085,
-0.009427514858543873,
-0.0009352036286145449,
-0.025241637602448463,
0.015677185729146004,
-0.004564759321510792,
-0.029173821210861206,
0.01927534118294716,
-0.0060187759809195995,
-0.017094522714614868,
-0.008035426959395409,
-0.02960549108684063,
-0.027448883280158043,
0.032611019909381866,
0.004581439308822155,
-0.014738387428224087,
-0.0005951644852757454,
-0.010941102169454098,
-0.006943308748304844,
-0.01010826975107193,
-0.02812928892672062,
0.024235978722572327,
-0.0009090122766792774,
0.01605645753443241,
0.00936498586088419,
-0.031234266236424446,
-0.018063560128211975,
0.007133115082979202,
0.003924583550542593,
-0.010813577100634575,
-0.07455217093229294,
-0.031769029796123505,
-0.005224448628723621,
-0.0008004996343515813,
-0.011988053098320961,
0.06656427681446075,
-0.014297761023044586,
-0.01284843124449253,
-0.025043578818440437,
0.002057541161775589,
0.0013767057098448277,
-0.0051972209475934505,
0.007718682289123535,
-0.0212002731859684,
0.006464166566729546,
-0.009954268112778664,
-0.009819833561778069,
0.006679975427687168,
-0.0036190992686897516,
0.0066845351830124855,
0.004554953426122665,
-0.0007589869201183319,
-0.009571792557835579,
-0.01754108816385269,
-0.011043393984436989,
-0.08157266676425934,
-0.02134867012500763,
0.025385987013578415,
-0.02073713019490242,
-0.008699160069227219,
0.010818162932991982,
0.004275496117770672,
-0.017510980367660522,
0.023943614214658737,
-0.014522649347782135,
-0.0014646872878074646,
0.020323870703577995,
0.0213137436658144,
0.015537450090050697,
0.010608399286866188,
-0.014830304309725761,
0.02689596451818943,
0.016650661826133728,
0.004470176063477993,
-0.0022803903557360172,
-0.025970976799726486,
-0.006370384246110916,
-0.009867322631180286,
-0.017750052735209465,
-0.008251940831542015,
-0.012193260714411736,
-0.028232812881469727,
0.013904903084039688,
-0.007106095086783171,
-0.002170878229662776,
-0.003872015280649066,
0.006084355525672436,
0.0019924514926970005,
-0.014993047341704369,
0.01270205806940794,
-0.01833268441259861,
0.003792814677581191,
-0.005584307014942169,
-0.011802008375525475,
-0.010223206132650375,
-0.003960671368986368,
0.031992118805646896,
0.024165058508515358,
0.014911184087395668,
0.004669928923249245,
-0.002154688350856304,
0.0013474351726472378,
-0.012450717389583588,
0.014227833598852158,
-0.00759651605039835,
0.012022744864225388,
0.009029990062117577,
-0.002507446799427271,
0.008801527321338654,
0.025799274444580078,
-0.012003738433122635,
0.0011912854388356209,
0.017782103270292282,
-0.009093032218515873,
0.003029918298125267,
0.007135485298931599,
0.016553828492760658,
-0.0012401603162288666,
0.07235687971115112,
-0.0032303580082952976,
0.00804581306874752,
-0.0071394252590835094,
-0.010960966348648071,
0.007127072662115097,
-0.038839712738990784,
-0.003131008241325617,
-0.010169520042836666,
-0.007266350090503693,
-0.0005617269780486822,
-0.018255293369293213,
-0.03055476024746895,
0.012969215400516987,
0.016789615154266357,
0.0013239490799605846,
0.0037608672864735126,
-0.021382782608270645,
-0.030681902542710304,
0.01497521623969078,
-0.00823121890425682,
0.034964337944984436,
0.02376030944287777,
0.002176381181925535,
-0.004180232062935829,
-0.005313312169164419,
-0.0008019935339689255,
0.00914711132645607,
0.006134150084108114,
0.0065309591591358185,
-0.005469738971441984,
-0.006546289660036564,
0.002029145136475563,
0.019424324855208397,
0.01897464133799076,
0.02220471203327179,
-0.002205158583819866,
0.0038890917785465717,
0.009802104905247688,
-0.02792166732251644,
-0.0049943095073103905,
0.010338476859033108,
-0.004815285559743643,
-0.013915789313614368,
0.01221077423542738,
-0.014097645878791809,
0.011781610548496246,
0.04045059159398079,
-0.006310439668595791,
0.017898455262184143,
-0.0141991525888443,
-0.003972169011831284,
0.015162757597863674,
0.026715459302067757,
0.008886105380952358,
0.002665380947291851,
-0.0105282012373209,
0.0076292757876217365,
-0.01757466048002243,
-0.0010749883949756622,
0.02716226689517498,
-0.011347594670951366,
0.007818633690476418,
-0.016075197607278824,
0.009631026536226273,
-0.017064590007066727,
-0.015265396796166897,
-0.011148613877594471,
-0.017228180542588234,
0.018551863729953766,
-0.01463550515472889,
0.005049216561019421,
0.009316490031778812,
-0.00013940036296844482,
-0.0044031282886862755,
0.012417617253959179,
0.020334262400865555,
-0.011255246587097645,
0.026822812855243683,
0.011036137118935585,
-0.006139026954770088,
0.019950836896896362,
-0.0011085330042988062,
0.0015612542629241943,
-0.009345723316073418,
0.006839546840637922,
-0.008353710174560547,
-0.0030311529990285635,
0.0044493949972093105,
0.011295335367321968,
-0.003622374963015318,
-0.002564546186476946,
0.010498574003577232,
-0.00875141378492117,
0.005805294960737228,
0.03242019936442375,
0.04716748371720314,
0.010970884002745152,
-0.016288693994283676,
0.012037636712193489,
0.008075891062617302,
-0.021714702248573303,
-0.0013211299665272236,
0.028240520507097244,
-0.005429964512586594,
0.004305041860789061,
-0.005948105826973915,
0.007255674339830875,
-0.00821191817522049,
-0.03513975068926811,
0.002234087325632572,
0.035076696425676346,
0.016946762800216675,
0.005316250957548618,
0.0002970350906252861,
0.027033619582653046,
-0.009311757981777191,
0.0018415568629279733,
0.02996770106256008,
-0.007582969963550568,
-0.008455304428935051,
0.0039424896240234375,
-0.019116118550300598,
0.010085074231028557,
0.008219973184168339,
-0.011478012427687645,
-0.006114121060818434,
0.012467123568058014,
-0.011308577843010426,
-0.01635340042412281,
0.020353063941001892,
-0.007737991400063038,
-0.0019034361466765404,
0.0190243162214756,
-0.000618881662376225,
-0.0012110760435461998,
0.006544090807437897,
0.005106724798679352,
0.007147856988012791,
0.005296060815453529,
-0.006284930277615786,
-0.01611219346523285,
0.006823760457336903,
0.001359365414828062,
0.007258787751197815,
-0.005803081206977367,
0.0064146979711949825,
0.029206672683358192,
0.006240442395210266,
-0.019632883369922638,
-0.011155147105455399,
0.01757011190056801,
-0.004048899747431278,
-0.007312010042369366,
-0.0017910674214363098,
0.01160275749862194,
0.0011038085212931037,
0.012038220651447773,
0.002074261661618948,
0.020333537831902504,
-0.01798967272043228,
0.04394802451133728,
0.01828995905816555,
-0.016407271847128868,
0.014189621433615685,
0.012159409001469612,
-0.00600889278575778,
0.011599930003285408,
-0.03205185383558273,
0.002272416837513447,
0.0012949761003255844,
-0.013984444551169872,
0.012184763327240944,
-0.013580601662397385,
0.0021879898849874735,
-0.022547628730535507,
-0.02155645564198494,
-0.016035016626119614,
-0.004741064738482237,
-0.002549579367041588,
0.008189686574041843,
-0.0014847249258309603,
0.008646581321954727,
-0.012818403542041779,
-0.0034134313464164734,
-0.019105831161141396,
-0.007404620759189129,
-0.0002698632888495922,
0.002833484672009945,
0.005817796569317579,
-0.012159829959273338,
0.0009527360089123249,
-0.017360514029860497,
0.023399382829666138,
-0.005803912878036499,
0.0009635100141167641,
-0.019497333094477654,
-0.002749756444245577,
-0.004414794966578484,
-0.0005509457550942898,
-0.0005088578909635544,
-0.015850335359573364
] | [
0.10145621746778488,
0.013134883716702461,
0.4206681251525879,
-0.0367862768471241,
-0.12949447333812714,
-0.07467985153198242,
0.2802199721336365,
-0.7235285639762878,
0.2034195363521576,
-0.5271430611610413,
-0.050565436482429504,
0.23667216300964355,
-0.7778006196022034,
0.07513388246297836,
-0.08218313008546829,
0.5410973429679871,
0.3387279212474823,
0.4755133092403412,
-0.04780253767967224,
-1.0308767557144165,
-0.16576258838176727,
-0.1943417340517044,
0.4268716275691986,
-0.14433680474758148,
0.3991885185241699,
0.05826878547668457,
0.6028845310211182,
-0.06398383527994156,
0.31870001554489136,
-0.27760693430900574,
0.043374352157115936,
0.575312614440918,
0.4886181056499481,
-0.000960630364716053,
0.0048504965379834175,
0.08669322729110718,
-0.024169472977519035,
0.10588423907756805,
0.33013686537742615,
0.04962635412812233,
-0.05324629694223404,
-0.4709829092025757,
0.05208661034703255,
0.3184393048286438,
-0.2876836061477661,
-0.5856972932815552,
-1.645342469215393,
0.9418495893478394,
-0.1878156214952469,
-0.3727179169654846,
-0.30585789680480957,
0.5397174954414368,
0.4815010130405426,
0.4584326446056366,
0.14321604371070862,
0.21929284930229187,
-0.6189975142478943,
-0.36296290159225464,
0.6657860279083252,
-0.4758561849594116,
-0.46362945437431335,
0.09738457947969437,
-0.08457828313112259,
0.18164733052253723,
-0.3530697524547577,
0.6220909357070923,
-0.07287634164094925,
-0.15313811600208282,
-0.728806734085083,
-0.24987393617630005,
0.1967082917690277,
-0.27764374017715454,
-0.26424452662467957,
-0.19740040600299835,
0.03333359584212303,
-0.08821233361959457,
-0.3648971617221832,
-0.019208885729312897,
0.3176509439945221,
-0.1330249160528183,
-0.016512693837285042,
0.04725473001599312,
-0.3108742833137512,
-0.09652870893478394,
0.6613880395889282,
0.332743376493454,
0.17054010927677155,
0.6442978978157043,
-0.6775522828102112,
-0.14003565907478333,
-0.13037064671516418,
-0.21990515291690826,
0.17974209785461426,
0.26091575622558594,
0.09041200578212738,
0.3572613298892975,
0.13424155116081238,
0.010084923356771469,
0.28803279995918274,
0.31345632672309875,
-0.4864922761917114,
-0.3332831561565399,
0.28485554456710815,
-0.4261455237865448,
-0.2702025771141052,
-0.3429451882839203,
-0.10383614152669907,
-0.609805166721344,
-0.47825193405151367,
0.3332175612449646,
-0.6744820475578308,
0.30235782265663147,
-0.5900763869285583,
-0.11203764379024506,
0.40336745977401733,
0.06084223464131355,
-0.12127796560525894,
-0.5002965927124023,
0.1574137955904007,
0.2979571521282196,
-0.056566689163446426,
1.580641508102417,
-0.24470731616020203,
0.08549565821886063,
0.21087127923965454,
0.09750166535377502,
0.383507639169693,
0.4479963481426239,
-0.275860071182251,
0.553075909614563,
0.4183790385723114,
0.9952340126037598,
-0.29137736558914185,
-0.1317025125026703,
-0.47731924057006836,
-0.2567541301250458,
0.18459752202033997,
0.15479035675525665,
-0.15557366609573364,
0.05157741531729698,
-0.2528674900531769,
-0.25602513551712036,
0.31520283222198486,
0.11294899135828018,
-0.03936315327882767,
0.2932133376598358,
-0.017418621107935905,
-0.31552866101264954,
0.05162525922060013,
-0.31435608863830566,
-0.06253248453140259,
-0.0435699038207531,
-0.8054498434066772,
0.07322868704795837,
-0.07716664671897888,
-0.013338930904865265,
0.15221068263053894,
-0.33007946610450745,
-0.338284969329834,
0.39762619137763977,
-0.01326780952513218,
0.09385262429714203,
-0.4668092727661133,
0.12676122784614563,
0.5987148284912109,
-0.3214416801929474,
0.36656320095062256,
0.6628909111022949,
-0.2682780921459198,
-0.0818009153008461,
-0.3137464225292206,
-0.16185209155082703,
0.14109909534454346,
-0.6023602485656738,
-0.002599684288725257,
-0.0647607147693634,
0.012603671289980412,
-0.5014063119888306,
0.10587857663631439,
0.10023490339517593,
-0.9271579384803772,
0.1018819734454155,
-0.1381753385066986,
-0.42024925351142883,
0.29831409454345703,
0.32408854365348816,
0.42945802211761475,
-0.18351119756698608,
0.222085639834404,
-0.07398073375225067,
-0.3110055923461914,
-0.04727727919816971,
0.3545891344547272,
-0.7655091881752014,
1.375205397605896,
0.13333478569984436,
-0.056390054523944855,
1.3076307773590088,
0.3787109851837158,
-0.09933154284954071,
-0.12653453648090363,
0.049537185579538345,
0.43141505122184753,
-0.28238195180892944,
-0.5519826412200928,
0.3606393337249756,
0.0815180316567421,
-0.0030406436417251825,
0.03778592497110367,
-0.14886032044887543,
0.6876373887062073,
-0.13892698287963867,
-0.36119070649147034,
-0.17431068420410156,
-0.03497685492038727,
-0.492668479681015,
0.072672538459301,
0.011765535920858383,
-0.3579627573490143,
0.2736724615097046,
0.21594637632369995,
-0.5260999798774719,
0.27008897066116333,
0.9853599667549133,
-0.25553423166275024,
0.8719543814659119,
0.9268884062767029,
0.37106817960739136,
0.5975760817527771,
-0.05000075697898865,
0.2073182910680771,
-0.29610151052474976,
0.24478664994239807,
-0.2838210165500641,
-0.164896160364151,
0.29439666867256165,
0.3503971993923187,
0.045376669615507126,
-0.00460284948348999,
-0.08882468938827515,
-0.31357839703559875,
0.7287266254425049,
-0.4573063254356384,
0.053350795060396194,
-0.4760133624076843,
-0.38662341237068176,
-0.3941214382648468,
0.3484167158603668,
-0.6538282632827759,
0.10617195814847946,
0.14541302621364594,
0.19543683528900146,
0.3226962089538574,
-0.5372811555862427,
0.07277000695466995,
0.2141038477420807,
-0.3375638425350189,
-0.45361772179603577,
-0.08144183456897736,
-0.15473933517932892,
-0.30076757073402405,
0.03235282003879547,
0.037610724568367004,
0.2974696159362793,
-0.04055820032954216,
-0.0579446442425251,
-0.5360087752342224,
-0.2757665514945984,
0.8946258425712585,
0.6699168086051941,
0.32507559657096863,
-0.3498304486274719,
-0.7528054714202881,
0.06615182757377625,
-0.17260921001434326,
-0.5155089497566223,
0.29621967673301697,
0.7349213361740112,
-0.48219773173332214,
-0.36069270968437195,
-0.26232996582984924,
0.36652684211730957,
0.6207261085510254,
-0.2864553928375244,
-0.25373151898384094,
-0.027073731645941734,
-0.013799052685499191,
-0.2630586326122284,
-0.4068525433540344,
-0.42455175518989563,
-0.585772693157196,
0.4317944645881653,
-0.2912871837615967,
-0.3478131592273712,
0.29041898250579834,
0.3977538049221039,
0.18424485623836517,
0.17304717004299164,
0.890993595123291,
0.24360105395317078,
-0.06276457756757736,
0.2081131786108017,
-0.22990313172340393,
-0.3434799015522003,
-0.15689300000667572,
0.007656536065042019,
-0.35591554641723633,
0.44905969500541687,
-6.042576313018799,
0.4283883273601532,
0.15049214661121368,
-0.08605339378118515,
-0.17370305955410004,
-0.2592533230781555,
0.9425586462020874,
0.060478828847408295,
0.2762966752052307,
-0.021845441311597824,
0.1568896323442459,
-0.12823529541492462,
-0.2677597403526306,
-0.19081665575504303,
-0.0013327143387869,
-0.054112356156110764,
0.356891393661499,
-0.2744652032852173,
0.8242649435997009,
-0.07650145888328552,
0.11886471509933472,
0.3704942464828491,
0.384430855512619,
0.08926025032997131,
0.1652369648218155,
-0.18549174070358276,
-0.7119742035865784,
-0.0392925888299942,
-0.25106531381607056,
-0.4152562618255615,
0.2798263132572174,
-0.30515074729919434,
0.07654837518930435,
-0.17042726278305054,
0.3214690387248993,
0.11744468659162521,
0.14098787307739258,
-0.004108408931642771,
0.016993166878819466,
0.04544853791594505,
0.48587095737457275,
0.0705978274345398,
-0.2421930432319641,
-0.13095156848430634,
0.2782769203186035,
-0.04532385617494583,
0.1735762506723404,
0.12603572010993958,
-0.2697807550430298,
0.5451978445053101,
-0.23812313377857208,
-0.152470201253891,
0.2944369614124298,
0.48509451746940613,
0.5650590658187866,
0.18447886407375336,
-0.32630905508995056,
0.2765631377696991,
-0.795864999294281,
-0.17127832770347595,
0.03663935884833336,
-0.03728530555963516,
-0.3571803867816925,
-0.5326341390609741,
0.09685106575489044,
0.24865837395191193,
-0.39897099137306213,
-0.3445362448692322,
0.7232892513275146,
-0.25503990054130554,
-0.2543492615222931,
0.012414474971592426,
0.4928402602672577,
-0.5793241858482361,
0.6699866056442261,
-0.06423646211624146,
0.08047538995742798,
0.1757674515247345,
-0.1166914701461792,
0.010538171976804733,
-0.43566057085990906,
-0.1777275800704956,
-0.023511894047260284,
-0.2553839683532715,
0.3421109616756439,
-0.1991633027791977,
-0.37274736166000366,
0.10076774656772614,
-0.45631858706474304,
0.6576035022735596,
0.39112621545791626,
-0.3136749267578125,
0.1467762589454651,
0.2571493089199066,
0.229983851313591,
0.4866120219230652,
0.6851043701171875,
0.35202518105506897,
0.43055403232574463,
0.17128047347068787,
0.7434519529342651,
0.04465123638510704,
-0.31478822231292725,
-0.9556835293769836,
0.07604880630970001,
0.24915488064289093,
-0.5495069622993469,
0.6112570762634277,
0.7604820132255554,
-0.5396417379379272,
0.23374593257904053,
-0.08710168302059174,
-0.32740268111228943,
-0.13622991740703583,
0.436066210269928,
-0.2402215451002121,
-0.15379250049591064,
-0.17340397834777832,
0.4790281653404236,
-0.14364992082118988,
0.03471900522708893,
0.2982012927532196,
-0.6067222356796265,
0.0843733623623848,
-0.169282466173172,
-0.05618886277079582,
0.13372404873371124,
0.5802984237670898,
-0.680115818977356,
-0.23874838650226593,
0.6560245156288147,
0.24422116577625275,
-0.7622249722480774,
-0.5211532711982727,
0.21337592601776123,
-0.17264728248119354,
0.2600702941417694,
0.5650976896286011,
0.44501492381095886,
-0.29676684737205505,
0.31810206174850464,
-0.2842441201210022,
-0.2934880256652832,
0.04879443719983101,
0.08042461425065994,
0.15193921327590942,
0.30034172534942627,
-0.08010421693325043,
-0.09918338805437088,
-0.38391396403312683,
0.18105489015579224,
0.16851608455181122,
0.2125420868396759,
-0.14641216397285461,
-0.17576803267002106,
0.49135980010032654,
0.40946632623672485,
-0.05361548811197281,
0.19567909836769104,
-0.651968777179718,
0.3756605088710785,
0.2158927023410797,
-0.8484718799591064,
-0.0888967514038086,
-0.1861446350812912,
-0.07482323795557022,
-0.490683376789093,
-0.1230936273932457,
-0.020210152491927147,
0.20120106637477875,
-0.31136050820350647,
-0.430900514125824,
-0.4749271273612976,
-0.08200728893280029,
0.10762085765600204,
-0.0026891727466136217,
-0.12390054762363434,
0.10914424806833267,
0.16220782697200775,
-0.12443584948778152,
-0.23057818412780762,
-0.3608751893043518,
0.0028765948954969645,
0.24258559942245483,
0.37775835394859314,
0.04677947610616684,
0.1676185429096222,
0.21938273310661316,
-0.1390668898820877,
-0.4255150556564331,
-0.21737293899059296,
0.07533914595842361,
0.7012686729431152,
-0.2922574281692505,
0.38452014327049255,
-0.2782819867134094,
0.1156836748123169,
0.7014544606208801,
-0.14052286744117737,
-0.4920349717140198,
-0.1108977422118187,
0.5643683671951294,
-0.5221123695373535,
0.16364632546901703,
0.2384747862815857,
0.1507781594991684,
-0.07016333192586899,
-0.001574016292579472,
0.32355138659477234,
-0.3593786954879761,
-0.2526848614215851,
-0.833699643611908,
-0.4613450765609741,
0.09576860070228577,
0.05072682350873947,
-0.23938095569610596,
0.13698862493038177,
0.1603640615940094,
-0.2601340711116791,
0.08664076775312424,
0.17854924499988556,
-0.3187987208366394,
-0.02956041879951954,
0.14260318875312805,
-0.13580045104026794,
0.28705406188964844,
-0.17059938609600067,
-1.020463466644287,
0.3505972623825073,
0.09621354937553406,
0.22232867777347565,
-0.3993256092071533,
0.23821520805358887,
0.3420403301715851,
-0.787031352519989,
-0.37660354375839233,
-0.8114800453186035,
0.44686633348464966,
-0.4548080563545227,
0.03069266676902771,
0.23803140223026276,
0.5894379615783691,
-0.40162932872772217,
-0.23060160875320435,
-0.08029911667108536,
0.6421858072280884,
0.3059740662574768,
-0.5198464393615723,
-0.37467294931411743,
-0.0026016910560429096,
0.27859216928482056,
0.02950606681406498,
0.211206316947937,
0.5016056895256042,
0.6555476784706116,
0.07590100914239883,
-0.12879067659378052,
-0.3513602316379547,
0.08773677796125412,
0.2777896225452423,
-0.3731624186038971,
0.08728636801242828,
-0.22306649386882782,
-0.06137900799512863,
-0.03469209745526314,
0.1418153941631317,
-0.0747600793838501,
-0.8022575378417969,
0.21648716926574707,
-0.15661832690238953,
-0.1142064705491066,
-0.18073897063732147,
0.6188739538192749,
0.986038088798523,
-0.11932037025690079,
0.3232633173465729,
-0.36786967515945435,
0.3681645095348358,
-0.1838969588279724,
0.0697987750172615,
-0.19296565651893616,
-0.6711813807487488,
0.27178874611854553,
-0.5072674751281738,
0.049134984612464905,
-0.5063437223434448,
-0.11865231394767761,
-0.33991560339927673,
0.030142569914460182,
-0.31954893469810486,
-0.47610732913017273,
0.34019479155540466,
-0.8360657095909119,
-0.5037256479263306,
0.009389739483594894,
-0.01992204412817955,
0.015519186854362488,
0.29063791036605835,
-0.04278818890452385,
-0.4372061789035797,
-0.5219125151634216,
0.10046405345201492,
0.595838725566864,
-0.6118931770324707,
0.28488215804100037,
0.15118087828159332,
-0.09414473921060562,
-0.061781615018844604,
-0.1861637383699417,
-0.3143618404865265,
0.052988629788160324,
0.025881947949528694,
0.37913909554481506,
-0.15487119555473328,
-0.2952154874801636,
0.22380639612674713,
-0.20622022449970245,
-0.027665624395012856,
0.22837527096271515,
0.3654869794845581,
0.22198700904846191,
0.5611468553543091,
0.5873649716377258,
0.12612523138523102,
-0.24653196334838867,
0.23138128221035004,
0.22159186005592346,
-0.11161524057388306,
-0.0022681676782667637,
0.413106769323349,
0.20245608687400818,
0.27599596977233887,
-0.27844130992889404,
0.5206676125526428,
0.31006017327308655,
0.05701787769794464,
0.03828875720500946,
-0.24312962591648102,
-0.34978848695755005,
-0.20915083587169647,
0.314032644033432,
0.146260067820549,
-0.21595484018325806,
-0.050312936305999756,
0.392046719789505,
-0.24936062097549438,
0.3895559310913086,
0.12219073623418808,
-0.37848690152168274,
0.7090237736701965,
0.05449632927775383,
-0.14041928946971893,
-0.5754743218421936,
-0.14966443181037903,
-0.5708677172660828,
0.12247920781373978,
0.5375975370407104,
-0.44024670124053955,
-0.3488490879535675,
0.12560105323791504,
0.11548838019371033,
-0.09903783351182938,
-0.4938998222351074,
0.12426837533712387,
-0.26694256067276,
-0.10823506116867065,
0.47077077627182007,
0.30182453989982605,
0.1621737778186798,
0.06350303441286087,
-0.1739250272512436,
0.11230101436376572,
-0.012829922139644623,
0.7509915828704834,
0.13992609083652496,
-0.1745218187570572,
0.23897860944271088,
0.16547907888889313,
-0.29616719484329224,
0.21745848655700684,
-0.22571951150894165,
0.07026214152574539,
-0.10045003145933151,
-0.23541498184204102,
-0.5096604824066162,
-0.5564495325088501,
-0.2912467122077942,
-0.7369441986083984,
-0.06788375973701477,
-0.05572044849395752,
0.3935116231441498,
-0.7775881290435791,
0.05806005001068115,
0.007606280967593193,
0.0937110185623169,
0.08048120141029358,
-0.18355914950370789,
0.5099217891693115,
0.3533211648464203,
0.5802826285362244,
0.09949098527431488,
0.1998489499092102,
0.1322271227836609,
0.4239565432071686,
-0.34447094798088074,
0.4288337528705597,
-0.44647520780563354,
-0.39105138182640076,
-0.42942753434181213,
-0.08785489946603775,
0.8937700986862183,
0.47393500804901123,
-0.15744765102863312,
-0.03382048010826111,
0.12672077119350433,
0.30942973494529724,
0.1693221926689148,
-0.6187987327575684,
-0.13094870746135712,
-0.570276141166687,
-0.07866474241018295,
-0.3226075768470764,
0.806195855140686,
-0.0035586159210652113,
-0.2746005058288574,
-0.25217747688293457,
0.33064913749694824,
0.295777827501297,
-0.260392963886261,
0.1963348388671875,
-0.4284697473049164,
-0.31323540210723877,
-0.41608238220214844,
0.492305725812912,
-0.5984776020050049,
0.3874247968196869,
-0.12951892614364624,
0.29929497838020325,
0.011745087802410126,
-0.1542726457118988,
-0.1826530396938324,
-0.1882467418909073,
0.19090531766414642,
0.1981096714735031,
0.036626093089580536,
0.25538328289985657,
0.16015057265758514,
-0.4541884660720825,
-0.4073505997657776,
0.2567317485809326,
0.32870832085609436,
-0.39825719594955444,
-0.2955317199230194,
0.2046314924955368,
0.13928937911987305,
0.2872094511985779,
-0.12600067257881165,
-0.49897798895835876,
-0.06844184547662735,
0.3120281994342804
] |
In July 1962, the author joined the Food Research Institute (FRI), then at the University of Chicago, to become its food virologist. There was a limited record of waterborne viral disease outbreaks at the time; recorded data on foodborne outbreaks were fewer still. Laboratory environmental (water and wastewater) virology was in its infancy, and food virology was in gestation. Detection of viruses was most often attempted by inoculation of primary primate cell cultures, with observation for plaque formation or cytopathic effects. Focus was initially on enteroviruses and reoviruses. Environmental and food samples had to be liquefied if not already in liquid form; clarified to remove solids, bacteria, and fungi; and concentrated to a volume that could be tested in cell culture. Cytotoxicity was also a concern. Studies at the FRI and some other laboratories addressed all of these challenges. The FRI group was the World Health Organization’s Collaborating Center for Food Virology for many years. Other topics studied were virus inactivation as functions of temperature, time, matrix, disinfectants, and microbial action; peroral and ex-vivo infectivity; and the suitability of various virus surrogates for environmental monitoring and inactivation experiments. Detection of noroviruses and hepatitis A virus required molecular methods, most often RT-PCR. When it was found that inactivated virus often gave the same RT-PCR signal as that of infectious virus, sample treatments were sought, which would prevent false-positive test results. Many laboratories around the world have taken up food and environmental virology since 1962, with the result that a dedicated journal has been launched. | [
0.007092026993632317,
0.013505700044333935,
-0.003089345060288906,
0.011432903818786144,
-0.017789430916309357,
0.013215404935181141,
0.010364868678152561,
0.014177151955664158,
-0.017519645392894745,
0.004602270666509867,
0.007195979822427034,
0.025331757962703705,
-0.006184605415910482,
-0.0016896160086616874,
0.0016864081844687462,
-0.00868486799299717,
-0.0025771167129278183,
-0.007138204760849476,
0.015530465170741081,
0.022134767845273018,
0.019298113882541656,
-0.012255281209945679,
0.010648400522768497,
-0.00561259500682354,
-0.004116327501833439,
-0.0022916519083082676,
0.004569778218865395,
-0.02378789335489273,
-0.0065226429142057896,
-0.006650364026427269,
0.03149019554257393,
-0.008569852448999882,
0.0016984522808343172,
0.01585623063147068,
0.0025714244693517685,
0.0031862561590969563,
0.0016626697033643723,
0.017542749643325806,
-0.0327589176595211,
-0.0035387033130973577,
0.001121132168918848,
-0.008732123300433159,
0.007478022016584873,
-0.009319968521595001,
-0.008662440814077854,
-0.03097488544881344,
-0.010903706774115562,
-0.01242767833173275,
0.0024406590964645147,
0.006245507393032312,
-0.022725768387317657,
-0.006565914023667574,
-0.005475311540067196,
0.014598679728806019,
-0.007113308645784855,
-0.014345042407512665,
0.020370300859212875,
0.018456529825925827,
-0.016918014734983444,
0.03350095450878143,
-0.015058806166052818,
0.0057321335189044476,
-0.02494167350232601,
-0.012042969465255737,
0.018781492486596107,
-0.06655840575695038,
-0.0009407401084899902,
0.008755156770348549,
0.017570126801729202,
-0.011251451447606087,
0.0008310460252687335,
0.01364273764193058,
-0.019599689170718193,
-0.020613431930541992,
0.004006474278867245,
0.01630467176437378,
0.0016271015629172325,
0.005502823740243912,
0.001992977224290371,
-0.008215273730456829,
0.012795766815543175,
-0.004165372811257839,
-0.019021790474653244,
0.014966296032071114,
-0.014987929724156857,
0.015340529382228851,
-0.012096373364329338,
0.024680692702531815,
-0.03017573431134224,
0.010312539525330067,
0.01935657672584057,
-0.034257419407367706,
-0.05451067164540291,
-0.030681155622005463,
-0.003521856851875782,
-0.003564523532986641,
0.013078278861939907,
0.015108002349734306,
-0.009523497894406319,
-0.05208548158407211,
0.0024643889628350735,
0.015195770189166069,
0.025911375880241394,
0.030919106677174568,
-0.008223599754273891,
0.0059402077458798885,
-0.008640017360448837,
0.02135399356484413,
0.010821009054780006,
0.005678882356733084,
0.0010740538127720356,
0.006925654597580433,
0.016715725883841515,
0.008191101253032684,
0.0024577730800956488,
-0.012516666203737259,
0.03521904721856117,
0.004977380391210318,
0.007560017053037882,
-0.009765980765223503,
0.008995733223855495,
-0.0037932279519736767,
-0.0026660372968763113,
0.0029163025319576263,
-0.0006221211515367031,
-0.01276808138936758,
0.002258396241813898,
-0.0344143882393837,
0.029120292514562607,
0.002768691862002015,
-0.00754933338612318,
-0.013113213703036308,
-0.015682004392147064,
-0.028475627303123474,
0.02067890390753746,
-0.0069736214354634285,
0.0031144379172474146,
0.016203047707676888,
-0.013866106048226357,
-0.01413816399872303,
-0.011043943464756012,
0.007858043536543846,
0.00829454604536295,
0.01458986010402441,
-0.012394633144140244,
0.00026591960340738297,
-0.014352098107337952,
0.008559491485357285,
0.040188804268836975,
-0.0017648539505898952,
0.010382995009422302,
-0.0035710735246539116,
0.009721078909933567,
-0.001123880734667182,
-0.027491290122270584,
-0.01562824472784996,
0.008676949888467789,
-0.010405096225440502,
0.0042810989543795586,
0.012277210131287575,
0.026774946600198746,
0.003117583692073822,
0.015560053288936615,
0.010699311271309853,
-0.0012757705990225077,
0.019515719264745712,
0.01927919127047062,
-0.0050009568221867085,
-0.010152535513043404,
0.0015157271409407258,
0.0022900132462382317,
-0.0023872549645602703,
-0.0028496209997683764,
0.013463770039379597,
0.01008985098451376,
0.0028233921620994806,
0.027401434257626534,
0.009500458836555481,
-0.003144236747175455,
0.06645594537258148,
0.022626187652349472,
-0.009849738329648972,
-0.03754529729485512,
0.0025370579678565264,
0.01729409396648407,
0.0005699326284229755,
0.035045772790908813,
0.001223250525072217,
-0.013149060308933258,
0.0022554537281394005,
-0.010393963195383549,
-0.0032572164200246334,
0.03405635058879852,
-0.014921395108103752,
0.0019365667831152678,
0.0034656720235943794,
0.008083577267825603,
-0.005249562673270702,
-0.0032172389328479767,
0.010548852384090424,
0.003849525237455964,
-0.009225020185112953,
0.005299180746078491,
0.011224012821912766,
-0.04015792906284332,
0.009953154250979424,
-0.0037364372983574867,
0.0015548990340903401,
-0.01569681242108345,
-0.002405501902103424,
0.01660853996872902,
-0.03318985179066658,
0.002146777929738164,
-0.01453222706913948,
-0.0008373183663934469,
0.0020051077008247375,
0.005696696694940329,
-0.0049293069168925285,
-0.020292043685913086,
-0.017613055184483528,
-0.002851590747013688,
0.015208367258310318,
-0.027013208717107773,
0.00868580024689436,
0.00742246862500906,
-0.01703537628054619,
0.0009368392638862133,
0.013934634625911713,
-0.007368304766714573,
-0.01394452340900898,
-0.0034519373439252377,
0.0010728116612881422,
-0.01220627874135971,
-0.014576379209756851,
0.008926855400204659,
0.017303815111517906,
0.0184133630245924,
0.001139933243393898,
0.004574441816657782,
-0.008813295513391495,
-0.011486413888633251,
-0.002649687696248293,
-0.0008370529394596815,
0.013706985861063004,
0.01867075264453888,
0.01951303333044052,
-0.005728309508413076,
0.018236564472317696,
0.00852628331631422,
-0.0011693029664456844,
0.006493409164249897,
0.002953177783638239,
0.019060319289565086,
-0.01814361661672592,
0.0347067266702652,
0.017465289682149887,
0.03376518189907074,
0.0014915051870048046,
0.026139527559280396,
-0.008099362254142761,
0.018813185393810272,
0.00611148402094841,
0.018700141459703445,
0.02447834238409996,
0.04627535492181778,
0.014501171186566353,
-0.003353009931743145,
0.001827852101996541,
0.016391078010201454,
0.021221686154603958,
0.008556414395570755,
-0.013539673760533333,
-0.0021378505043685436,
-0.08152194321155548,
-0.01599380001425743,
0.0037379830610007048,
0.01372813805937767,
0.009110670536756516,
-0.006007886957377195,
0.020742014050483704,
-0.0017019601073116064,
0.002788417972624302,
0.027967456728219986,
-0.0022706068120896816,
0.024179678410291672,
-0.009795868769288063,
0.0204169824719429,
-0.0002466244623064995,
-0.011809472925961018,
0.017181944102048874,
-0.006487761624157429,
-0.005649958737194538,
-0.01376039907336235,
-0.02066148817539215,
-0.0008853087201714516,
0.005110044032335281,
-0.010105229914188385,
-0.010701239109039307,
0.01261159311980009,
-0.0035835052840411663,
0.003179111983627081,
0.02821071818470955,
0.006657566875219345,
0.007478051353245974,
-0.01757602021098137,
0.016560332849621773,
-0.000854983925819397,
-0.005719894543290138,
0.0012142402119934559,
0.006571119651198387,
-0.017011871561408043,
0.003383482340723276,
0.03635469451546669,
-0.004476937465369701,
0.020468760281801224,
-0.00738831702619791,
-0.02149522677063942,
0.014718935824930668,
-0.006359423510730267,
-0.007776916958391666,
0.023271340876817703,
0.022506024688482285,
0.015314407646656036,
0.004688354209065437,
-0.011726128868758678,
0.003129202639684081,
0.014879323542118073,
-0.018766352906823158,
-0.023892242461442947,
-0.0036294437013566494,
0.03224627673625946,
-0.006039721425622702,
-0.005829131230711937,
-0.025387976318597794,
0.0020783990621566772,
-0.0068014622665941715,
0.005468824878334999,
-0.03666722774505615,
0.03201515972614288,
0.00975677091628313,
0.02453356608748436,
-0.0006083722691982985,
0.01968234032392502,
-0.007616225630044937,
-0.0031744090374559164,
0.012489615008234978,
-0.005303952842950821,
-0.0073345196433365345,
0.001534259645268321,
-0.017893455922603607,
-0.01062828116118908,
0.01908469758927822,
-0.029405925422906876,
-0.017836980521678925,
-0.0016468275571241975,
-0.015687990933656693,
-0.005109765566885471,
-0.01006483007222414,
0.026995087042450905,
0.016227222979068756,
0.01688362844288349,
0.01007959246635437,
-0.02538922242820263,
0.04121006280183792,
0.00036026560701429844,
-0.0476420596241951,
0.01342608593404293,
-0.022179365158081055,
0.010370748117566109,
-0.019360605627298355,
-0.014171799644827843,
0.005200989544391632,
0.009797477163374424,
-0.019677096977829933,
-0.016449466347694397,
-0.027391094714403152,
-0.009313905611634254,
-0.0242619626224041,
0.012551105581223965,
0.0018232185393571854,
0.01830160804092884,
-0.011850417591631413,
-0.011614145711064339,
0.011076521128416061,
-0.01629554107785225,
-0.002667963271960616,
-0.02739802561700344,
0.01642104610800743,
0.009595362469553947,
0.01044037751853466,
-0.030217180028557777,
0.07183118164539337,
-0.012294068932533264,
0.005306038074195385,
-0.014891632832586765,
-0.014244470745325089,
-0.034302037209272385,
-0.0013668006286025047,
-0.006663445383310318,
0.013317272067070007,
-0.010830379091203213,
0.013836979866027832,
0.008768013678491116,
-0.014564817771315575,
-0.02610468864440918,
0.017651543021202087,
0.0012422277359291911,
0.01233066525310278,
0.002588298637419939,
-0.02494572103023529,
-0.023776758462190628,
-0.01243402436375618,
0.010935721918940544,
-0.013721341267228127,
0.0040356433019042015,
0.04426296055316925,
-0.008521972224116325,
-0.01205714512616396,
-0.014283989556133747,
0.0032925987616181374,
-0.002363773062825203,
0.005735238082706928,
-0.0009422525763511658,
-0.007466619368642569,
-0.01283760741353035,
0.0012629511766135693,
0.019438814371824265,
0.014347750693559647,
0.007947804406285286,
-0.005022926721721888,
0.0037212457973510027,
-0.001265387050807476,
-0.009548327885568142,
-0.002418537624180317,
0.014380786567926407,
-0.0015627541579306126,
-0.004876222927123308,
0.011268875561654568,
-0.003092869184911251,
-0.024355631321668625,
0.00961814820766449,
-0.006969781592488289,
0.01655421406030655,
0.005710069555789232,
-0.019489850848913193,
-0.017913363873958588,
-0.021356362849473953,
0.0009953430853784084,
-0.00021500885486602783,
-0.00011966004967689514,
-0.02286047488451004,
-0.013369150459766388,
-0.024884693324565887,
-0.02448427677154541,
-0.016742471605539322,
-0.012031733989715576,
-0.012000169605016708,
0.004256686195731163,
0.0049588740803301334,
0.025231938809156418,
-0.03307333588600159,
-0.026788579300045967,
-0.028576668351888657,
-0.012985259294509888,
-0.009770962409675121,
-0.01873243972659111,
-0.0054371170699596405,
-0.027682051062583923,
-0.013303344137966633,
-0.02800562046468258,
0.013058053329586983,
-0.007513567339628935,
0.006444830447435379,
0.02109985239803791,
-0.011325739324092865,
-0.000270983437076211,
-0.0028648620937019587,
-0.03647424280643463,
-0.07451014220714569,
0.011119849048554897,
-0.021153761073946953,
-0.0036097054835408926,
0.019892286509275436,
0.011972589418292046,
-0.023074615746736526,
0.03076910600066185,
-0.01662740856409073,
0.002606573048979044,
-0.018450859934091568,
0.0009710846934467554,
0.04039581120014191,
0.008889146149158478,
0.019928891211748123,
-0.01116655208170414,
-0.00587029242888093,
0.012051243335008621,
-0.0027710292488336563,
0.015145870856940746,
0.03928326070308685,
-0.011040174402296543,
-0.03426167368888855,
-0.008823651820421219,
0.0025329128839075565,
-0.08088456094264984,
0.008543441072106361,
0.002147456631064415,
-0.047362104058265686,
0.005902651697397232,
-0.006793339736759663,
-0.014198935590684414,
-0.012747014872729778,
-0.003943508490920067,
-0.016208531334996223,
0.01824098266661167,
-0.0032560420222580433,
-0.0037736771628260612,
-0.0025898264721035957,
0.024085093289613724,
0.0012603201903402805,
0.0044511654414236546,
-0.028595414012670517,
0.002435983158648014,
0.010199550539255142,
0.019300751388072968,
0.016934834420681,
-0.006687338463962078,
-0.00648467568680644,
-0.0014387640403583646,
-0.014401889406144619,
-0.03548327460885048,
0.0054585253819823265,
0.00269964337348938,
-0.00647920835763216,
0.002549461554735899,
0.024502292275428772,
-0.015997160226106644,
-0.0001941472291946411,
0.03276935964822769,
-0.017134450376033783,
0.04077158495783806,
0.009174627251923084,
0.025373224169015884,
-0.0009982483461499214,
-0.007918605580925941,
0.013906454667448997,
0.015471644699573517,
0.0027751291636377573,
0.007608775980770588,
-0.008306534960865974,
0.011561945080757141,
-0.007146539632230997,
0.018152210861444473,
-0.02301112562417984,
0.007662084884941578,
-0.01873360574245453,
0.020689167082309723,
0.01650787889957428,
-0.0027423480059951544,
0.004853063728660345,
0.0018499463330954313,
0.002541373483836651,
-0.004058113321661949,
0.006551194936037064,
-0.003902916330844164,
0.012955335900187492,
-0.006481669843196869,
0.07142700999975204,
-0.016188137233257294,
0.0015343952691182494,
-0.0038076709024608135,
-0.008957580663263798,
0.00021095466217957437,
-0.019885212182998657,
-0.016422860324382782,
0.0012400669511407614,
-0.02576177939772606,
-0.0008646994829177856,
-0.016094094142317772,
-0.01638016477227211,
0.003213190473616123,
-0.024219008162617683,
0.007342849392443895,
0.0054839979857206345,
0.011458402499556541,
0.0004399707540869713,
-0.0011017471551895142,
-0.020111052319407463,
-0.0030588144436478615,
-0.02173224277794361,
-0.01437673531472683,
0.02547740563750267,
0.009822705760598183,
-0.04602246731519699,
0.013311218470335007,
0.00022204173728823662,
0.01325503084808588,
-0.013351472094655037,
0.0147744445130229,
0.003175637684762478,
0.0051856511272490025,
0.009800971485674381,
-0.0022392706014215946,
0.015314786694943905,
0.012078363448381424,
-0.0034532244317233562,
0.029674222692847252,
-0.014024611562490463,
0.014508550986647606,
0.003960523288697004,
-0.02996295690536499,
0.0356467142701149,
-0.020467674359679222,
0.0059054214507341385,
0.010267166420817375,
0.004070146940648556,
0.016527747735381126,
-0.009408245794475079,
0.0096510611474514,
0.02497689798474312,
0.022927796468138695,
-0.006787275895476341,
0.009722154587507248,
-0.032099053263664246,
0.023983372375369072,
0.007326057180762291,
0.009756892919540405,
-0.006181105971336365,
-0.020726418122649193,
-0.01694287732243538,
-0.024666838347911835,
0.009014185518026352,
-0.015396260656416416,
0.0016966769471764565,
-0.01734316535294056,
-0.03640972077846527,
0.007514535449445248,
0.0037517633754760027,
0.02804204635322094,
0.001959489192813635,
0.017800670117139816,
0.010429763235151768,
0.002441719640046358,
0.03295281529426575,
0.018540512770414352,
0.0074045369401574135,
0.024972766637802124,
-0.019204407930374146,
-0.01577015407383442,
0.026776205748319626,
0.011165911331772804,
-0.0206898283213377,
0.01873256266117096,
-0.02185710519552231,
0.0010122759267687798,
-0.008187107741832733,
0.0020851579029113054,
-0.011574694886803627,
-0.003294057212769985,
0.0061514731496572495,
-0.0017153793014585972,
0.014490153640508652,
0.03577271103858948,
0.033939070999622345,
0.0038793478161096573,
0.022846415638923645,
0.006194464396685362,
0.0040459586307406425,
0.008152061142027378,
-0.005229042377322912,
-0.004015919752418995,
-0.0033962347079068422,
-0.004413093440234661,
0.007241831161081791,
0.030619218945503235,
0.004059760831296444,
0.03495737537741661,
-0.040582604706287384,
-0.020268816500902176,
-0.001692033838480711,
-0.005977488122880459,
-0.0016626175493001938,
-0.00007508881390094757,
-0.0018015073146671057,
-0.005183953791856766,
-0.006173789966851473,
-0.015467343851923943,
-0.018075911328196526,
-0.019579418003559113,
0.0033624093048274517,
0.03282240778207779,
0.005680921487510204,
-0.004758574068546295,
-0.00664041843265295,
-0.014886273071169853,
-0.0009379051625728607,
0.0004705730825662613,
0.011035212315618992,
0.024367380887269974,
-0.023619215935468674,
0.011726360768079758,
-0.006827208679169416,
-0.017961131408810616,
0.00907805934548378,
-0.016001025214791298,
-0.024335050955414772,
-0.02171739935874939,
-0.02032417617738247,
-0.0027766134589910507,
0.004488663747906685,
-0.009871037676930428,
0.011846603825688362,
0.007006289903074503,
0.012608565390110016,
-0.014305466786026955,
0.0121536236256361,
0.014295998960733414,
0.005564849823713303,
0.01560160145163536,
0.0020688683725893497,
-0.002405405044555664,
-0.009226653724908829,
0.00005027139559388161,
0.01777956262230873,
0.009033727459609509,
-0.0159612949937582,
0.00020221422892063856,
-0.00640315655618906,
-0.006309887859970331,
0.022822847589850426,
0.007246525026857853,
0.0036536245606839657,
0.010913592763245106,
0.018087338656187057,
-0.014191310852766037,
-0.002724217250943184,
0.025747280567884445,
0.005380725488066673,
-0.023575298488140106,
-0.0015993230044841766,
0.0006306993309408426,
-0.012991775758564472,
-0.01630987972021103,
-0.002056884579360485,
0.009944132529199123,
-0.03230307251214981,
0.0227633286267519,
-0.0038341840263456106,
0.02557852305471897,
0.007013692986220121,
-0.013224218040704727,
-0.0004284332972019911,
0.005293293856084347,
-0.008110670372843742,
0.021655317395925522,
-0.003586997278034687,
0.01448347419500351,
-0.004413454793393612,
-0.012783809565007687,
0.005479019600898027,
-0.014115873724222183,
0.018375523388385773,
0.00044283270835876465,
-0.017025694251060486,
-0.0031449422240257263,
0.006879151798784733,
0.0013556035701185465,
0.010242222808301449,
-0.0024882247671484947
] | [
0.1600257307291031,
0.44691362977027893,
-0.5281851291656494,
-0.06013678386807442,
0.10539943724870682,
0.16655530035495758,
0.592266321182251,
-0.21649019420146942,
-0.21160219609737396,
-0.3251314163208008,
0.2279871702194214,
0.28269240260124207,
-0.32944872975349426,
0.46053260564804077,
0.04754827916622162,
0.035669922828674316,
0.3099577724933624,
-0.21979239583015442,
-0.1694074124097824,
0.0312834158539772,
-0.5824403762817383,
-0.28783339262008667,
-0.10564989596605301,
0.3067500591278076,
0.06338293850421906,
-0.25475242733955383,
0.4265373647212982,
-0.08770106732845306,
0.4603936970233917,
-0.21950100362300873,
0.2589549422264099,
0.1303291916847229,
0.037494778633117676,
-0.5510140657424927,
-0.3687831461429596,
-0.10318516194820404,
-0.5032748579978943,
0.3028217852115631,
0.15282395482063293,
-0.42206060886383057,
0.07063350081443787,
0.30366578698158264,
-0.4706762731075287,
-0.004092834424227476,
0.12504397332668304,
-0.5335298776626587,
-1.2992005348205566,
0.5173889994621277,
-0.2038649320602417,
0.4112967848777771,
0.0634051039814949,
-0.004560752771794796,
-0.004004155285656452,
-0.16214029490947723,
-0.06589628010988235,
0.42765921354293823,
-0.40768513083457947,
0.17034250497817993,
0.22050142288208008,
-0.19244974851608276,
0.12027788907289505,
-0.3259948492050171,
0.09834129363298416,
0.46266376972198486,
-0.28682371973991394,
0.7170637845993042,
0.34536853432655334,
0.37727054953575134,
0.2907622754573822,
-0.2821299433708191,
0.026913508772850037,
-0.5589187145233154,
-0.1534859985113144,
0.0868719220161438,
0.3093881607055664,
-0.3381406366825104,
0.5006698369979858,
-0.44710567593574524,
0.003974814433604479,
0.5261820554733276,
-0.4793170988559723,
0.06812499463558197,
-0.37597689032554626,
-0.48319923877716064,
0.5393158197402954,
0.29287511110305786,
-0.2779148519039154,
0.6220666766166687,
-0.2902281582355499,
0.04465172439813614,
0.13536036014556885,
-0.05926559865474701,
0.49066483974456787,
-0.10510557144880295,
0.31458520889282227,
-0.07265283167362213,
-0.2727646827697754,
0.3791015148162842,
0.33425745368003845,
-0.026242123916745186,
-0.6716502904891968,
0.07058708369731903,
0.15141206979751587,
0.14880181849002838,
-0.2985897362232208,
0.18110473453998566,
-0.007912623696029186,
-0.6193845272064209,
-0.5237340927124023,
0.00819172989577055,
0.23618242144584656,
0.1244538277387619,
-0.01995723694562912,
0.21873337030410767,
-0.3015071451663971,
0.23048272728919983,
0.34497368335723877,
-0.6279019117355347,
-0.36655011773109436,
-0.134634867310524,
-0.7020562887191772,
0.5272624492645264,
0.10194997489452362,
0.6290503740310669,
-0.32360202074050903,
-0.24963490664958954,
0.3315618336200714,
0.5342632532119751,
-0.40964779257774353,
0.6402731537818909,
-0.04397305101156235,
0.7956729531288147,
0.188768669962883,
-0.06294940412044525,
-0.14577192068099976,
0.27655699849128723,
-0.31468021869659424,
0.30077269673347473,
-0.18892358243465424,
-0.05400524660944939,
-0.18675297498703003,
-0.7885777354240417,
-0.17443519830703735,
0.18900232017040253,
0.007089018356055021,
-0.2356805056333542,
0.14440053701400757,
0.06614674627780914,
-0.3963923454284668,
-0.11353596299886703,
0.20565636456012726,
-0.23504354059696198,
-0.46407485008239746,
0.057142578065395355,
0.36707133054733276,
0.8548317551612854,
-0.1781621277332306,
0.47635674476623535,
0.16638225317001343,
0.012281007133424282,
0.479590505361557,
0.29156380891799927,
-0.30475515127182007,
-0.1569826304912567,
0.19473141431808472,
-0.222206249833107,
-0.027528520673513412,
0.1620413064956665,
0.28779932856559753,
0.39664819836616516,
-0.06838034093379974,
-0.5081376433372498,
-0.16189920902252197,
-0.2852921187877655,
-0.011134380474686623,
0.06585625559091568,
0.4244805574417114,
-0.08421804010868073,
0.18437199294567108,
0.4495556652545929,
-0.36790984869003296,
-0.1117989644408226,
-0.23809348046779633,
-0.46767929196357727,
0.2314569503068924,
-0.03805539757013321,
0.3319578766822815,
-0.09057541191577911,
-0.11521275341510773,
0.03528033569455147,
-0.5793889164924622,
-0.3873751759529114,
0.6042667627334595,
-0.6407997012138367,
1.1890580654144287,
0.045043688267469406,
-0.3317009210586548,
1.312825322151184,
-0.0639149397611618,
0.0273198951035738,
0.18079042434692383,
0.44855326414108276,
0.3841666877269745,
-0.5795500874519348,
-1.0335947275161743,
-0.07268677651882172,
0.212619811296463,
-0.5384920835494995,
-0.15669304132461548,
0.37918853759765625,
0.3488323986530304,
0.08917782455682755,
0.005249821115285158,
-0.5424267053604126,
0.39248138666152954,
0.5477108359336853,
-0.060611553490161896,
0.28818368911743164,
0.14194248616695404,
-0.3844310939311981,
0.24492013454437256,
-0.81511390209198,
0.3885769844055176,
0.4286913573741913,
0.18694591522216797,
0.5885202288627625,
0.7494013905525208,
0.05099976807832718,
0.7921833395957947,
-0.6871529221534729,
0.22508305311203003,
-0.5416732430458069,
0.7769238352775574,
-0.6038411855697632,
-0.22919180989265442,
0.06660288572311401,
-0.08732934296131134,
0.023112192749977112,
-0.15580998361110687,
0.3148731589317322,
0.9625734686851501,
0.17566658556461334,
-0.6107298731803894,
0.17056035995483398,
-0.009756701067090034,
-0.25878921151161194,
0.0813714787364006,
-0.382073312997818,
-0.3488047420978546,
0.4357137978076935,
-0.016149291768670082,
0.7744134664535522,
0.4241469204425812,
-0.1499222368001938,
0.20320895314216614,
0.017867177724838257,
-0.28933557868003845,
-0.20553414523601532,
0.7954418063163757,
0.1337943822145462,
-0.18034356832504272,
-0.12340952455997467,
-0.10416518896818161,
0.18556071817874908,
0.2873138189315796,
-0.2926996946334839,
-0.278585821390152,
-0.8250436186790466,
0.3785904347896576,
0.49615296721458435,
0.6948782801628113,
0.2006720006465912,
-0.4027103781700134,
0.19015850126743317,
0.26855379343032837,
-0.8758834004402161,
0.5349230766296387,
0.7999614477157593,
-0.03620050847530365,
-0.6213895678520203,
-0.3380544185638428,
0.31247591972351074,
0.23014017939567566,
-0.6103891134262085,
0.10492781549692154,
-0.5737134218215942,
-0.09877229481935501,
-0.32312241196632385,
-0.4970906674861908,
0.07387556880712509,
-0.3086561858654022,
0.346759557723999,
-0.37994202971458435,
-0.24434959888458252,
-0.304438978433609,
0.3796025812625885,
-0.2380628138780594,
0.046032242476940155,
0.27992552518844604,
-0.08702272176742554,
-0.1729377806186676,
0.022961031645536423,
-0.22949253022670746,
0.1829816848039627,
-0.0301384087651968,
0.25270581245422363,
0.17239511013031006,
-0.047248367220163345,
-6.090544700622559,
-0.07455022633075714,
-0.058857742697000504,
-0.2852407395839691,
-0.25613120198249817,
0.2480900138616562,
0.9773423075675964,
-0.12701930105686188,
0.7081130743026733,
-0.1710909605026245,
0.34693899750709534,
0.27258381247520447,
0.33081164956092834,
0.06077498942613602,
0.16452525556087494,
0.1764507293701172,
-0.0034896177239716053,
-0.3480636775493622,
-0.20261895656585693,
0.19309565424919128,
0.39274582266807556,
-0.17308703064918518,
-0.13991673290729523,
0.43218326568603516,
-0.20301543176174164,
0.3009960949420929,
-0.7981048226356506,
0.8666017055511475,
-0.2153273969888687,
0.32337671518325806,
0.39231228828430176,
-0.7728147506713867,
0.061703383922576904,
-0.23842401802539825,
-0.7093594074249268,
0.19222381711006165,
0.25786158442497253,
-0.010486694052815437,
-0.09123079478740692,
0.2263844758272171,
-0.025451000779867172,
-0.0014330631820484996,
-0.3294881582260132,
-0.5691539645195007,
-0.009953641332685947,
-0.2631690204143524,
0.11668455600738525,
-0.058536164462566376,
-0.03742026537656784,
0.6244478225708008,
-0.129009410738945,
0.3067794144153595,
0.22672684490680695,
0.5011538863182068,
0.146476149559021,
-0.27817732095718384,
0.26231634616851807,
-0.08955293148756027,
-0.3775181770324707,
-0.04998893290758133,
0.10304250568151474,
-0.13424542546272278,
0.32907071709632874,
-0.578463613986969,
0.3485952317714691,
0.02904757484793663,
-0.4514767825603485,
-0.06601636111736298,
-0.16083742678165436,
0.017979471012949944,
-0.2884443700313568,
0.21162883937358856,
0.017074836418032646,
-1.0271378755569458,
-0.3197389841079712,
-0.5517446398735046,
0.29613614082336426,
-0.5059658885002136,
0.07631031423807144,
-0.448619544506073,
-0.555496096611023,
-0.3567751944065094,
-0.31785961985588074,
0.17022158205509186,
-0.08012036979198456,
-0.3593045473098755,
-0.06811245530843735,
-0.1766146719455719,
-0.682201623916626,
-0.16432064771652222,
0.4223190248012543,
-0.06567509472370148,
-0.07366461306810379,
0.5189887881278992,
0.09177855402231216,
0.5388896465301514,
0.12855471670627594,
0.2583678662776947,
0.5512319803237915,
-0.0344264954328537,
0.3747471272945404,
-0.27280959486961365,
-0.35732927918434143,
-0.8367217183113098,
0.006310928612947464,
-0.18419097363948822,
-0.5174164175987244,
-0.28370335698127747,
0.5543605089187622,
-0.3335556089878082,
-0.22360143065452576,
0.2969755530357361,
-0.2812904119491577,
-0.3266679346561432,
0.44265785813331604,
0.08554528653621674,
0.5998712182044983,
0.08611946552991867,
0.6292421221733093,
0.06982313841581345,
0.20567269623279572,
0.1648777276277542,
0.03965435177087784,
0.28169846534729004,
0.6056853532791138,
-0.6632071137428284,
0.402477502822876,
0.07212479412555695,
-0.37235227227211,
-0.2254926711320877,
0.0071514868177473545,
0.49508988857269287,
0.1705595999956131,
-0.12378715723752975,
0.5642632246017456,
0.04700794816017151,
-0.8684984445571899,
-0.4847830533981323,
0.009173269383609295,
0.14273521304130554,
-0.5031478404998779,
-0.03225501626729965,
-0.08548030257225037,
0.0774674043059349,
-0.3108712434768677,
0.10653182864189148,
0.19173578917980194,
0.2588135302066803,
0.09720391035079956,
0.021193349733948708,
-0.03115563653409481,
0.05497419089078903,
0.15499350428581238,
0.27817997336387634,
-0.7470125555992126,
-0.0874728187918663,
0.5444421172142029,
0.03683754801750183,
-0.11415399610996246,
-0.3588898479938507,
0.05765371397137642,
-0.22227029502391815,
-0.8096730709075928,
-0.010559063404798508,
0.05255028232932091,
-0.07147641479969025,
0.17186439037322998,
-0.2404724359512329,
0.17573702335357666,
-0.1275792270898819,
-0.1399841010570526,
-0.42846474051475525,
-0.20687516033649445,
0.33424827456474304,
-0.20777660608291626,
0.34692147374153137,
-0.24089840054512024,
-0.1694062203168869,
-0.4533706307411194,
0.2022639364004135,
0.31738948822021484,
-0.38155248761177063,
-0.5062889456748962,
0.6468042135238647,
0.7888748049736023,
0.29774680733680725,
-0.39065834879875183,
-0.7142452001571655,
-0.6553503274917603,
0.17053627967834473,
-0.04691987484693527,
0.24496571719646454,
0.6254143714904785,
0.5192002654075623,
-0.38833579421043396,
-0.09928032755851746,
-0.582848846912384,
0.1873806267976761,
-0.19821102917194366,
-0.09615525603294373,
-0.2416449934244156,
0.18022724986076355,
-0.23175615072250366,
0.014561246149241924,
0.035172153264284134,
-0.7286349534988403,
-0.29505595564842224,
-0.06560920178890228,
0.23817704617977142,
-0.08715269714593887,
0.008490798063576221,
0.13575194776058197,
0.10763370990753174,
0.7887026071548462,
-0.053538985550403595,
0.19618940353393555,
0.1179790124297142,
-0.1511286050081253,
0.03137631714344025,
0.2620193064212799,
-0.1604849249124527,
0.16581112146377563,
-0.35627683997154236,
-0.5049914717674255,
-0.10073774307966232,
0.8230403065681458,
0.5440905690193176,
-0.6677038073539734,
-0.0330866314470768,
0.23620235919952393,
-0.19450034201145172,
-0.34879788756370544,
0.37286725640296936,
0.2405748963356018,
-0.7247084379196167,
0.15229390561580658,
0.5903270244598389,
-0.12027949839830399,
0.09947894513607025,
0.4714950621128082,
0.36464208364486694,
0.436909556388855,
-0.2278043031692505,
0.03734675049781799,
0.19623340666294098,
-0.04396535083651543,
0.2219976782798767,
-0.4652152955532074,
-0.16146071255207062,
0.020673412829637527,
-0.33181315660476685,
-0.012511659413576126,
0.08491235226392746,
0.019839847460389137,
0.7113008499145508,
0.21492744982242584,
-0.30251339077949524,
-0.3674003779888153,
0.2228204607963562,
-0.1620849370956421,
0.12873879075050354,
0.16695867478847504,
-0.5101962685585022,
-0.021336296573281288,
0.006220200099050999,
-0.03856787830591202,
-0.326828271150589,
-0.3174375891685486,
0.19501279294490814,
-0.26272472739219666,
-0.230325847864151,
-0.2845839262008667,
-0.05625161528587341,
0.703065037727356,
-0.12375510483980179,
0.38277068734169006,
-0.49643048644065857,
-0.032382797449827194,
-0.1513461023569107,
0.17541058361530304,
-0.6121601462364197,
-0.18604327738285065,
-0.17352992296218872,
-0.23030643165111542,
-0.17062197625637054,
-0.08639200031757355,
0.30632874369621277,
-0.2616479694843292,
0.18960271775722504,
-0.360627144575119,
-0.168228417634964,
0.20293621718883514,
-0.8332489132881165,
-0.13159072399139404,
0.2689489424228668,
0.09446603059768677,
0.0662427619099617,
0.4996546506881714,
-0.37834468483924866,
-0.16035382449626923,
-0.5563800930976868,
0.390485554933548,
0.3973159193992615,
-0.8179970383644104,
0.22623805701732635,
0.07721982896327972,
0.4009724259376526,
0.7794406414031982,
-0.3969397246837616,
0.1718665063381195,
0.020552050322294235,
-0.09792160242795944,
-0.2105240821838379,
0.38219141960144043,
-1.08518648147583,
0.4209331274032593,
-0.09655161947011948,
-0.5291130542755127,
0.253375768661499,
-0.30520865321159363,
0.4860248863697052,
0.2992918789386749,
-0.014784461818635464,
-0.16627058386802673,
-0.5641263723373413,
0.6885450482368469,
-0.26645225286483765,
0.4745396673679352,
-0.3319779932498932,
0.22609767317771912,
0.6877802610397339,
0.34203699231147766,
-0.20868687331676483,
0.18571946024894714,
-0.4573611617088318,
0.4051041901111603,
0.19765032827854156,
-0.6083567142486572,
-0.1049070954322815,
0.17217344045639038,
0.532444417476654,
0.24446366727352142,
-0.2757120132446289,
-0.019525041803717613,
-0.3509886860847473,
-0.10403189808130264,
0.13219955563545227,
0.025934090837836266,
0.004902200773358345,
0.4092589020729065,
0.22837767004966736,
0.09942314028739929,
0.14880089461803436,
0.3890359103679657,
-0.1585545837879181,
-0.42277300357818604,
0.32745352387428284,
-0.3513784110546112,
-0.3659365177154541,
-0.08406179398298264,
0.060693494975566864,
0.22506941854953766,
0.39825934171676636,
0.5518098473548889,
0.09931116551160812,
0.520904541015625,
0.4376260042190552,
-0.32093390822410583,
0.0781092420220375,
-0.14863193035125732,
0.287105530500412,
-0.30990657210350037,
-0.6466041207313538,
0.6570982933044434,
0.0349251851439476,
-0.03153446689248085,
0.11159685254096985,
0.16602852940559387,
0.0786648765206337,
-0.08721626549959183,
-0.3206917941570282,
-0.5182712078094482,
-0.1653081327676773,
-0.5430470108985901,
0.03918541967868805,
0.07726229727268219,
-0.20761850476264954,
0.48851868510246277,
-0.1255572885274887,
-0.20291879773139954,
0.317767471075058,
-0.9910339713096619,
0.04861697182059288,
0.5370574593544006,
-0.3734521269798279,
0.3564048409461975,
0.3152225911617279,
0.45045509934425354,
-0.021187977865338326,
0.12057526409626007,
-0.3140049874782562,
-0.16751673817634583,
-0.1556077003479004,
0.3746868371963501,
-0.47717297077178955,
1.013961911201477,
-0.4522959291934967,
-0.20067282021045685,
-0.3081343173980713,
0.13647036254405975,
0.6556602716445923,
0.315310537815094,
-0.0613301582634449,
-0.3439655005931854,
-0.10513104498386383,
-0.24130350351333618,
0.21583770215511322,
-0.6397714614868164,
0.2362758070230484,
-0.3216390609741211,
-0.2090260237455368,
-0.3383651077747345,
-0.14453808963298798,
0.14791372418403625,
-0.29953455924987793,
0.05273060500621796,
-0.07315627485513687,
0.4439834654331207,
-0.24466228485107422,
0.2681962251663208,
0.27260008454322815,
0.08773327618837357,
-0.5008497834205627,
0.33934012055397034,
-0.28534695506095886,
-0.22478525340557098,
0.5352884531021118,
0.5711450576782227,
0.005219611804932356,
-0.06299537420272827,
0.21261154115200043,
-0.09073927998542786,
0.27446600794792175,
0.2773929536342621,
-0.27719584107398987,
0.3026520609855652,
0.07557463645935059,
-0.14898118376731873,
-0.2441793978214264,
0.2773296535015106,
-0.2730485200881958,
0.17290475964546204,
-0.6632607579231262,
0.05173919349908829,
-0.2672576606273651,
0.2881178855895996,
0.08583434671163559,
-0.32410556077957153,
-0.03159918636083603,
0.04535339027643204
] |
Management of flu pandemic is a perpetual challenge for the medical fraternity since time immemorial. Animal to human transmission has been observed thrice in the last century within an average range of 11-39 years of antigenic recycling. The recent outbreak of influenza A (H1N1, also termed as swine flu), first reported in Mexico on April 26, 2009, occurred in the forty first year since last reported flu pandemic (July 1968). Within less than 50 days, it has assumed pandemic proportions (phase VI) affecting over 76 countries with 163 deaths/35,928 cases (as on 15(th) June 2009). It indicated the re-emergence of genetically reassorted virus having strains endemic to humans, swine and avian (H5N1). The World Health Organisation (WHO) member states have already pulled up their socks and geared up to combat such criticalities. Earlier outbreaks of avian flu (H5N1) in different countries led WHO to develop pandemic preparedness strategies with national/regional plans on pandemic preparedness. Numerous factors related to climatic conditions, socio-economic strata, governance and sharing of information/logistics at all levels have been considered critical indicators in monitoring the dynamics of escalation towards a pandemic situation. The National Disaster Management Authority (NDMA), Government of India, with the active cooperation of UN agencies and other stakeholders/experts has formulated a concept paper on role of nonhealth service providers during pandemics in April 2008 and released national guidelines - management of biological disasters in July 2008. These guidelines enumerate that the success of medical management endeavors like pharmaceutical (anti-viral Oseltamivir and Zanamivir therapies), nonpharmaceutical interventions and vaccination development etc., largely depends on level of resistance offered by mutagenic viral strain and rationale use of pharmaco therapeutic interventions. This article describes the mitigation approach to combat flu pandemic with its effective implementation at national, state and local levels. | [
-0.02451825514435768,
0.017193786799907684,
-0.012532606720924377,
-0.0007598419906571507,
0.008597803302109241,
0.006759603042155504,
0.006938929669559002,
0.01303412951529026,
-0.013382552191615105,
-0.03819366171956062,
-0.0004299101419746876,
0.016518589109182358,
0.013449062593281269,
-0.007838429883122444,
0.02406194806098938,
-0.015424286015331745,
-0.0158906951546669,
0.007089221850037575,
0.014048529788851738,
-0.011028651148080826,
-0.0061987233348190784,
-0.003239281475543976,
0.008861437439918518,
0.02849000133574009,
0.027112392708659172,
-0.016096200793981552,
0.0016687940806150436,
0.00048457318916916847,
0.0016489583067595959,
-0.024512287229299545,
0.0025007417425513268,
0.02102423459291458,
-0.006590048782527447,
-0.008266594260931015,
0.00816408358514309,
0.010304613970220089,
-0.0017262895125895739,
0.011888587847352028,
-0.007131214253604412,
-0.002641664119437337,
0.01996821165084839,
-0.019387993961572647,
0.0008585654431954026,
-0.0018472515512257814,
-0.00858224742114544,
0.043427251279354095,
-0.01089375838637352,
-0.001436534570530057,
-0.012672986835241318,
0.007484577130526304,
-0.0018036079127341509,
-0.014820508658885956,
-0.009911846369504929,
0.012966487556695938,
-0.005347047932446003,
-0.0035428060218691826,
0.017086809501051903,
0.024991163983941078,
-0.01908942125737667,
0.02571309730410576,
-0.010121401399374008,
-0.0029343776404857635,
0.00918181799352169,
-0.013808328658342361,
0.008662808686494827,
-0.0673353374004364,
0.0035670672077685595,
0.0157394390553236,
-0.0004629627801477909,
0.008155899122357368,
0.003906652797013521,
0.0007945543620735407,
-0.0014495630748569965,
-0.014487680047750473,
-0.01147652417421341,
0.014619407244026661,
0.014814005233347416,
0.021961037069559097,
-0.01125575415790081,
-0.019278783351182938,
0.011935971677303314,
-0.0037516248412430286,
0.0071641807444393635,
0.018387312069535255,
-0.003382590599358082,
-0.005225294269621372,
-0.005341893993318081,
-0.0028355976101011038,
-0.016518976539373398,
0.02165837027132511,
0.0011787116527557373,
-0.01155192032456398,
-0.03370648995041847,
-0.012705177068710327,
0.00780827272683382,
-0.03359827399253845,
-0.020620033144950867,
-0.0018937778659164906,
-0.03870754688978195,
-0.011569763533771038,
0.007836929522454739,
0.018212314695119858,
0.005232288036495447,
0.0442904457449913,
0.011411622166633606,
0.003355262568220496,
-0.0009435255778953433,
0.008943982422351837,
0.002319249790161848,
-0.0059468671679496765,
-0.021222233772277832,
-0.0017736887093633413,
0.0019236914813518524,
-0.010814126580953598,
-0.02650413289666176,
0.023785661906003952,
0.005335299763828516,
0.017591092735528946,
-0.010035805404186249,
-0.006031037773936987,
0.014984008856117725,
-0.010496162809431553,
0.0019919495098292828,
0.0032069189473986626,
0.0000028936774469912052,
0.0015023984014987946,
-0.014348287135362625,
-0.0073251547291874886,
-0.004400293342769146,
0.0002880580723285675,
-0.003316683229058981,
0.006533961743116379,
-0.02975372038781643,
-0.022395234555006027,
-0.008753111585974693,
0.0036193926353007555,
-0.01669623889029026,
0.009678835980594158,
-0.0058376360684633255,
-0.0003568020183593035,
-0.027318231761455536,
0.009450098499655724,
-0.0025169046130031347,
0.01567435823380947,
0.012318831868469715,
-0.001387189025990665,
-0.025256218388676643,
0.016487298533320427,
0.02572789043188095,
0.012241458520293236,
-0.0021515474654734135,
0.004440048709511757,
-0.013534314930438995,
-0.0011341150384396315,
-0.015563548542559147,
0.008559387177228928,
-0.0052244700491428375,
-0.027103979140520096,
-0.0027089689392596483,
0.03245564550161362,
0.013024529442191124,
-0.004585118964314461,
-0.02645815908908844,
0.006346380338072777,
0.009530576877295971,
-0.012617748230695724,
0.008103602565824986,
-0.007100972346961498,
-0.012334630824625492,
0.0075847129337489605,
-0.001700778491795063,
0.014826943166553974,
-0.020136453211307526,
0.017036592587828636,
0.030114954337477684,
-0.01718311756849289,
-0.00193848367780447,
0.0036809295415878296,
0.0193950142711401,
0.06676752865314484,
-0.02754785493016243,
-0.009871769696474075,
0.005605859216302633,
0.003187148831784725,
0.007160679437220097,
-0.005195635370910168,
0.026902586221694946,
-0.00457334890961647,
0.004309513606131077,
-0.004350236151367426,
0.0038729028310626745,
0.0014800970675423741,
0.006278000306338072,
-0.031363651156425476,
-0.006815436761826277,
0.004340518265962601,
0.003976238425821066,
-0.00043858797289431095,
0.012050448916852474,
0.007980205118656158,
0.0056384047493338585,
-0.006842648144811392,
0.04934347793459892,
0.001670940313488245,
-0.005291533190757036,
0.0045553697273135185,
0.018580153584480286,
-0.001353203784674406,
0.003125194227322936,
-0.011297497898340225,
0.00787876546382904,
-0.006494077388197184,
-0.007678741589188576,
-0.006515125744044781,
0.0009528137743473053,
0.0075566875748336315,
0.021531619131565094,
0.004021278582513332,
-0.010742214508354664,
-0.015463074669241905,
0.00006868969649076462,
-0.004627457354217768,
-0.03230753540992737,
0.027740780264139175,
0.0018522951286286116,
-0.00237076822668314,
0.010740552097558975,
0.0075877076014876366,
0.0058412086218595505,
0.009713825769722462,
-0.002518880181014538,
0.015040476806461811,
-0.0054872771725058556,
-0.028152577579021454,
0.002678148914128542,
-0.011666128411889076,
0.009068487212061882,
-0.0022259498946368694,
0.006961413659155369,
-0.013153612613677979,
-0.014994913712143898,
-0.016697045415639877,
0.015828870236873627,
-0.024866197258234024,
0.019363444298505783,
-0.005799154285341501,
0.01841871440410614,
0.0008945930749177933,
-0.029204167425632477,
0.008089326322078705,
0.010153720155358315,
-0.005824870429933071,
0.014417888596653938,
0.007338147610425949,
0.01755986362695694,
-0.0008223447948694229,
0.013811375945806503,
0.0007394722197204828,
0.02503451518714428,
0.01889457367360592,
0.018924245610833168,
0.009698577225208282,
-0.015946686267852783,
0.00838865339756012,
-0.004209304694086313,
0.02402045950293541,
0.006051390897482634,
-0.02321617677807808,
0.008076965808868408,
0.012403146363794804,
0.0023935476783663034,
-0.011684313416481018,
-0.0015677721239626408,
-0.0821915715932846,
-0.00358030223287642,
0.0031111545395106077,
-0.0017645959742367268,
0.00922695267945528,
0.003490339033305645,
0.019447676837444305,
-0.007956912741065025,
-0.007601425051689148,
0.026000846177339554,
-0.009059051983058453,
0.007030867971479893,
0.011029730550944805,
-0.022276323288679123,
-0.003189653158187866,
0.0028962832875549793,
0.003962863236665726,
0.012739120982587337,
-0.0052385288290679455,
-0.029775915667414665,
0.0035847255494445562,
0.012692472897469997,
0.010062276385724545,
-0.01798509806394577,
-0.015399731695652008,
-0.012166783213615417,
0.01688971370458603,
0.012804914265871048,
-0.003855733433738351,
0.007477683015167713,
0.00300307828001678,
-0.01701599918305874,
-0.008524531498551369,
-0.00848744809627533,
0.02410590648651123,
0.0029590248595923185,
0.0024923565797507763,
-0.0005346827674657106,
0.007626537699252367,
-0.005798645317554474,
0.015251414850354195,
0.005469543393701315,
0.010915165767073631,
-0.010704733431339264,
-0.007342078723013401,
-0.0029267945792526007,
0.01174141839146614,
0.006394319701939821,
0.027668947353959084,
0.02039160579442978,
-0.0013288699556142092,
-0.01949300616979599,
0.019954252988100052,
0.008748214691877365,
-0.002008316107094288,
-0.00426232535392046,
0.007227370049804449,
0.0032000821083784103,
-0.009271841496229172,
0.0027027041651308537,
-0.03672460466623306,
0.03063543513417244,
-0.005522208753973246,
-0.003056592307984829,
-0.031861111521720886,
-0.015187486074864864,
0.012380341067910194,
-0.031923286616802216,
-0.003524300642311573,
0.011361619457602501,
0.0005289078690111637,
-0.007488030008971691,
0.011120172217488289,
-0.012164660729467869,
0.013369007036089897,
-0.005824855994433165,
-0.014589030295610428,
-0.007238063495606184,
0.00020970264449715614,
-0.011017048731446266,
-0.024386253207921982,
-0.006907628383487463,
-0.0014904569834470749,
0.0038262316957116127,
-0.01992420107126236,
0.00003554113209247589,
0.013096299022436142,
0.00016797264106571674,
0.015775948762893677,
-0.019844772294163704,
0.009958814829587936,
0.01743292063474655,
-0.023217888548970222,
0.009201299399137497,
-0.007755969185382128,
-0.014703068882226944,
0.00442378968000412,
0.005159024614840746,
-0.006501542869955301,
0.006499333307147026,
-0.00770240742713213,
-0.01950039714574814,
-0.0007476286264136434,
-0.009750831872224808,
0.011368864215910435,
0.009763294830918312,
0.014098377898335457,
-0.03543233126401901,
-0.01658807322382927,
-0.0058815861120820045,
0.01981472596526146,
0.004919445142149925,
0.0004884667578153312,
-0.008607009425759315,
0.01352652721107006,
-0.00394861213862896,
0.004688713699579239,
-0.02424456737935543,
0.0720551460981369,
-0.00703609362244606,
0.0033330386504530907,
-0.020581858232617378,
0.03810206055641174,
-0.03007802739739418,
0.01450883038341999,
-0.009646808728575706,
0.005633438937366009,
-0.015048006549477577,
0.013192390091717243,
-0.021602094173431396,
0.0041769081726670265,
-0.024870101362466812,
-0.0009136215085163713,
-0.008980784565210342,
0.0019834842532873154,
0.006810770835727453,
0.027305547147989273,
-0.02338561788201332,
0.017630087211728096,
0.01042542140930891,
-0.00949842669069767,
-0.015359788201749325,
0.024730971083045006,
0.00702150072902441,
0.014015264809131622,
-0.015135489404201508,
0.010661238804459572,
0.0027176348958164454,
-0.0006659528007730842,
-0.010435874573886395,
-0.0044869850389659405,
0.001532481168396771,
0.00052312680054456,
0.012778585776686668,
-0.003746927483007312,
0.012297283858060837,
0.007522229105234146,
-0.005919148679822683,
0.0015317276120185852,
-0.011273582465946674,
-0.01184090506285429,
0.007657552137970924,
-0.010175976902246475,
0.0007448778487741947,
-0.0038643721491098404,
-0.007740188390016556,
-0.01679590716958046,
0.02780478447675705,
0.0059944698587059975,
0.015634499490261078,
0.003938313573598862,
0.019754495471715927,
-0.02284792624413967,
0.013973702676594257,
0.00284742028452456,
-0.007943126372992992,
0.014959635213017464,
-0.005440808832645416,
-0.00004813913255929947,
-0.015651443973183632,
-0.01692364737391472,
-0.01704944297671318,
-0.018029026687145233,
0.0003931920509785414,
-0.017517760396003723,
0.014698752202093601,
-0.011454140767455101,
0.005343925207853317,
-0.005536491516977549,
-0.006623199209570885,
-0.0015452932566404343,
-0.018465297296643257,
-0.03672259300947189,
0.015065222978591919,
-0.013249823823571205,
0.026629267260432243,
-0.0273432694375515,
0.02619299851357937,
-0.001112128607928753,
-0.013321984559297562,
-0.005631518550217152,
-0.004919922910630703,
-0.004206674173474312,
-0.02044115960597992,
-0.011719189584255219,
-0.07505503296852112,
-0.02281240001320839,
-0.0033586611971259117,
-0.008270460180938244,
0.01051542442291975,
-0.015069069340825081,
-0.029325079172849655,
-0.016098396852612495,
-0.002228370402008295,
-0.010045952163636684,
0.0025210040621459484,
0.010137178003787994,
0.05097305774688721,
0.006955120246857405,
0.017751142382621765,
-0.01528397761285305,
-0.015290172770619392,
0.017177633941173553,
-0.008657095953822136,
0.000033060554414987564,
0.010284577496349812,
0.007355911657214165,
-0.03374791145324707,
0.007104577496647835,
-0.008356453850865364,
-0.08105970919132233,
-0.009842710569500923,
0.019846921786665916,
-0.029683489352464676,
-0.00464158970862627,
-0.008205611258745193,
0.01613137498497963,
-0.03691265732049942,
-0.006584337912499905,
-0.011864404194056988,
0.018020346760749817,
-0.004888521041721106,
-0.0028637887444347143,
0.014153522439301014,
0.02015857771039009,
-0.005042523145675659,
0.013845999725162983,
0.005095912143588066,
0.018652522936463356,
0.007961772382259369,
0.03547094762325287,
0.02941793203353882,
-0.005027060396969318,
-0.016332212835550308,
-0.005784980021417141,
0.0019358282443135977,
-0.010174909606575966,
0.003116017673164606,
0.0073347087018191814,
0.01855022832751274,
-0.02000243216753006,
-0.015402842313051224,
0.003020323347300291,
0.009739172644913197,
0.04394371062517166,
-0.0014628442004323006,
0.012980339117348194,
-0.01817483827471733,
0.02359333261847496,
-0.011294761672616005,
-0.0035761697217822075,
0.02388760633766651,
-0.015397987328469753,
-0.023768937215209007,
0.028481123968958855,
0.021055229008197784,
0.01082459557801485,
-0.009802622720599174,
0.016630491241812706,
-0.00712038716301322,
0.0013961289077997208,
-0.03473909944295883,
0.0011947937309741974,
0.0020433133468031883,
-0.028965942561626434,
-0.011130934581160545,
-0.007029383908957243,
0.0023023015819489956,
0.006875974126160145,
0.020603086799383163,
-0.0066171749494969845,
0.0022409544326364994,
0.0015941548626869917,
0.0716695636510849,
-0.011585270054638386,
0.023569311946630478,
-0.0051331548020243645,
-0.007472628727555275,
0.0014588080812245607,
-0.0015828311443328857,
-0.0018566548824310303,
-0.014669336378574371,
-0.01523360051214695,
0.03191976249217987,
-0.006590255536139011,
0.0016821366734802723,
0.0038061721716076136,
-0.0074285282753407955,
0.0262482650578022,
0.02284853905439377,
-0.008032029494643211,
-0.03074171021580696,
-0.015498016029596329,
-0.006461316253989935,
0.008328638970851898,
-0.00022135907784104347,
-0.016725122928619385,
0.014086468145251274,
0.019444402307271957,
-0.021335791796445847,
0.014261818490922451,
0.009287427179515362,
0.00129731185734272,
-0.001331421546638012,
0.0017166109755635262,
0.00673409178853035,
-0.00938424188643694,
-0.006268313620239496,
-0.0187978558242321,
0.010076072067022324,
0.017317943274974823,
0.016082532703876495,
0.012913282960653305,
0.021688707172870636,
-0.008372518233954906,
0.012291677296161652,
0.010297257453203201,
0.023042339831590652,
-0.005272937007248402,
-0.004374952986836433,
0.019994240254163742,
0.007995544001460075,
0.017078323289752007,
-0.0013213763013482094,
0.014083301648497581,
-0.009176431223750114,
-0.01045822724699974,
0.009980864822864532,
0.02127784863114357,
-0.013156980276107788,
0.014541903510689735,
-0.007248328533023596,
-0.015625089406967163,
0.014256658032536507,
-0.009884531609714031,
-0.01184457540512085,
-0.006572612561285496,
0.00038216356188058853,
-0.007102291565388441,
0.03348071873188019,
-0.0032272047828882933,
0.02546856738626957,
0.0005479345563799143,
-0.01254564244300127,
0.005761808715760708,
0.005396092776209116,
0.0016294736415147781,
0.014394938014447689,
0.03096948005259037,
0.043186284601688385,
0.004926279187202454,
0.008001153357326984,
0.02136559784412384,
-0.01796860247850418,
-0.022587571293115616,
0.002881808439269662,
0.009935285896062851,
-0.005207175854593515,
-0.013689910061657429,
0.01571359671652317,
-0.022121982648968697,
-0.0173131562769413,
0.004296841099858284,
0.004039539489895105,
0.004426183179020882,
0.002096246462315321,
-0.02243046835064888,
0.012567928992211819,
0.035355545580387115,
0.026572335511446,
0.0009884939063340425,
0.02828880399465561,
-0.002718416042625904,
-0.014695893041789532,
0.006020605098456144,
0.0139954574406147,
-0.0064127687364816666,
0.006121678277850151,
-0.015749074518680573,
-0.0003081904724240303,
0.01310803648084402,
0.019813990220427513,
0.015776459127664566,
-0.00796855241060257,
0.014208728447556496,
0.005689259618520737,
0.0030914624221622944,
0.00949538592249155,
0.008236692287027836,
0.001953081227838993,
0.024609766900539398,
-0.004460778087377548,
-0.008052529767155647,
-0.004860328510403633,
-0.012998544611036777,
0.003338605398312211,
0.024315301328897476,
0.010012008249759674,
0.005599836353212595,
-0.004113445989787579,
-0.006978049874305725,
-0.01363694854080677,
0.002102861413732171,
0.008590880781412125,
0.005930488929152489,
0.007123156450688839,
0.002119357232004404,
-0.012273725122213364,
-0.018487179651856422,
0.030303344130516052,
0.005644162651151419,
-0.007593604736030102,
-0.008495548740029335,
0.01409435085952282,
0.003079772926867008,
0.014864599332213402,
0.004093720577657223,
0.010395659133791924,
0.0009800281841307878,
-0.0016264813020825386,
0.0008941744454205036,
0.009723503142595291,
-0.002435545437037945,
0.00011256476864218712,
0.007926064543426037,
0.006550279445946217,
0.0012481341836974025,
0.009990032762289047,
-0.012537620961666107,
0.01043936051428318,
-0.02587999403476715,
-0.0029446682892739773,
0.01794876903295517,
0.006777414120733738,
0.019762545824050903,
0.010786022990942001,
-0.01461037527769804,
-0.010689102113246918,
0.007755506783723831,
0.0005161878652870655,
0.00007136678323149681,
0.007124047726392746,
0.007319370284676552,
-0.0011513547506183386,
-0.012860502116382122,
-0.015300150029361248,
0.020840592682361603,
0.002946942113339901,
-0.012846620753407478,
-0.005796821787953377,
0.03783554956316948,
-0.025843655690550804,
0.0042184628546237946,
0.017053719609975815,
-0.012867303565144539,
0.018980130553245544,
-0.007513977121561766,
-0.0071181245148181915,
0.013947926461696625,
-0.013504688628017902,
0.001968137454241514,
0.02630631998181343,
0.005367171950638294,
-0.01466451771557331,
-0.025281107053160667,
0.01020164042711258,
0.013209199532866478,
0.012508693151175976,
-0.011402156203985214,
-0.011775670573115349,
-0.017677951604127884,
0.010315299034118652,
0.009631314314901829,
0.014845352619886398,
0.01776479370892048
] | [
0.03581679239869118,
-0.2128576636314392,
0.06227332353591919,
-0.10452073067426682,
-0.20609453320503235,
0.08290529251098633,
0.6029645800590515,
0.5097591876983643,
-0.585129976272583,
-0.3604808747768402,
0.22515499591827393,
0.07133128494024277,
-0.6772470474243164,
0.6176859140396118,
-0.012411280535161495,
0.15398885309696198,
0.5566920638084412,
0.2978772521018982,
-0.2527247369289398,
-0.32675379514694214,
-0.47297561168670654,
-0.7460841536521912,
0.39768263697624207,
0.2996790409088135,
-0.22595180571079254,
-0.4234427213668823,
0.03290116414427757,
-0.3006725013256073,
0.3009425699710846,
0.09131421148777008,
0.28578945994377136,
0.3682354688644409,
0.16206049919128418,
-0.34489041566848755,
-0.5328518152236938,
0.2452240288257599,
-0.4628910720348358,
-0.035332128405570984,
-0.19692400097846985,
-0.39171770215034485,
-0.2023611217737198,
-0.04404424875974655,
-0.38538992404937744,
-0.0061168186366558075,
-0.11964508146047592,
-0.5716956853866577,
-0.8718734979629517,
0.6667895913124084,
-0.15659935772418976,
0.09623326361179352,
-0.6241951584815979,
-0.15816767513751984,
0.2690466046333313,
-0.013181419111788273,
-0.19892437756061554,
0.3919070363044739,
-0.7629892826080322,
0.16623064875602722,
-0.4699566960334778,
-0.14984241127967834,
0.1325133740901947,
-0.4754074215888977,
0.31183427572250366,
0.26169154047966003,
-0.48316991329193115,
-0.05325031280517578,
0.4106610119342804,
0.6722255945205688,
0.32640939950942993,
-0.6394511461257935,
-0.3751021921634674,
-0.3905749022960663,
-0.30492305755615234,
-0.31295087933540344,
-0.09365211427211761,
-0.9463616013526917,
-0.0724337100982666,
-0.4504750370979309,
-0.0365004725754261,
0.670721173286438,
-0.04034925997257233,
0.296186625957489,
0.2445690631866455,
-0.9583808779716492,
0.8301427960395813,
-0.10290873795747757,
0.28169092535972595,
0.7484562397003174,
0.0003278657968621701,
-0.042136091738939285,
0.5099589228630066,
-0.03222266212105751,
0.7597510814666748,
-0.3853018879890442,
-0.11409171670675278,
0.1522352546453476,
0.29372215270996094,
-0.20409023761749268,
0.25423744320869446,
-0.441636860370636,
-0.3166707158088684,
-0.007726246025413275,
0.12497691065073013,
-0.2540542185306549,
-0.20536038279533386,
-0.3826560080051422,
0.22011597454547882,
-0.38823121786117554,
-0.1059570387005806,
-0.17602795362472534,
0.026154911145567894,
-0.1195359006524086,
-0.04586667940020561,
-0.17591756582260132,
-0.46870654821395874,
0.5139386057853699,
0.4754544198513031,
-0.4871663749217987,
0.4769359827041626,
-0.12331923842430115,
-0.0004256850515957922,
0.444759339094162,
-0.00005577046613325365,
0.2660195827484131,
-0.3319070339202881,
-0.11051656305789948,
0.5392383337020874,
-0.16398897767066956,
-0.02701852284371853,
0.10124678909778595,
0.04159656539559364,
0.6266961097717285,
0.06428438425064087,
-0.050846491008996964,
0.20582084357738495,
-0.06746642291545868,
-0.09408420324325562,
0.24452297389507294,
0.2796827554702759,
-0.44947320222854614,
-0.26008400321006775,
-0.5693938732147217,
-0.6215100288391113,
0.08234853297472,
0.13341639935970306,
-0.007616542745381594,
-0.023477943614125252,
-0.2744242548942566,
-0.37307506799697876,
-0.2779344618320465,
-0.13773518800735474,
-0.08336000889539719,
-0.33762603998184204,
0.30086150765419006,
0.18221701681613922,
0.3744906783103943,
-0.34141820669174194,
-0.6333005428314209,
0.11325264722108841,
0.037780847400426865,
0.6791115403175354,
-0.1636187583208084,
-0.0531686469912529,
-0.13113617897033691,
0.12985005974769592,
-0.26071059703826904,
-0.14522601664066315,
0.869762122631073,
-0.22851406037807465,
-0.3771924376487732,
-0.20988477766513824,
-0.16778509318828583,
0.17484211921691895,
-0.6143103837966919,
0.10554633289575577,
-0.21950462460517883,
0.2769281566143036,
0.32766517996788025,
0.400937557220459,
0.7593253254890442,
-0.4191533625125885,
0.15751779079437256,
0.15385927259922028,
-0.24008238315582275,
0.22439637780189514,
-0.18868669867515564,
0.24713197350502014,
0.12283462285995483,
0.29077136516571045,
0.5017733573913574,
-0.49612781405448914,
-0.06816336512565613,
0.4229067265987396,
-0.18747477233409882,
0.833579421043396,
0.12282976508140564,
-0.23634684085845947,
1.3423750400543213,
0.007592720445245504,
-0.1570485234260559,
-0.036363616585731506,
0.1869373470544815,
0.6554661393165588,
-0.518225908279419,
-1.1801294088363647,
0.0459221713244915,
0.2341916412115097,
-0.2077367603778839,
-0.3598227798938751,
0.43530839681625366,
-0.074744313955307,
-0.339624285697937,
-0.059209905564785004,
-0.24830785393714905,
0.26620352268218994,
0.3271467387676239,
-0.2711668014526367,
-0.1606413573026657,
0.359188437461853,
-0.5062564611434937,
0.302956223487854,
-0.3923413157463074,
-0.06012427434325218,
0.742960512638092,
0.0494687482714653,
0.12695248425006866,
0.3583635687828064,
-0.0735287144780159,
1.1194181442260742,
-0.9184888005256653,
0.41120946407318115,
-0.4363807737827301,
0.7263644933700562,
-0.23970180749893188,
-0.07090844959020615,
0.3003945052623749,
-0.15186160802841187,
-0.04300427436828613,
-0.11427329480648041,
0.08417835831642151,
0.6309023499488831,
0.15487360954284668,
-0.2611391842365265,
0.8344547748565674,
0.1988256275653839,
0.020243773236870766,
0.23755423724651337,
-0.31216275691986084,
-0.6076470613479614,
0.07121867686510086,
0.23710587620735168,
0.8320416212081909,
0.3271312415599823,
-0.5275588035583496,
0.09808406233787537,
0.02435741201043129,
0.3952086567878723,
-0.08254574984312057,
0.3706761300563812,
-0.002651562448590994,
-0.021216580644249916,
0.05321771278977394,
-0.10247592628002167,
0.4873800277709961,
0.3349413275718689,
-0.8410440683364868,
-0.6543452739715576,
-0.3810446560382843,
-0.15214803814888,
-0.2323760986328125,
0.8426012992858887,
-0.06098479777574539,
-0.24831999838352203,
0.13441048562526703,
0.27235159277915955,
-0.47753509879112244,
0.15318723022937775,
0.7145341038703918,
-0.5341846942901611,
0.06968996673822403,
-0.18122532963752747,
0.3394617438316345,
0.4977038502693176,
-0.7241852879524231,
-0.22508743405342102,
-0.46514394879341125,
-0.04721910133957863,
-0.6762461066246033,
-0.24266688525676727,
-0.09556461870670319,
-0.0959244817495346,
0.18526136875152588,
0.1306769847869873,
0.24691958725452423,
-0.39380431175231934,
-0.4680662453174591,
-0.12903308868408203,
0.8011462092399597,
0.8872390389442444,
-0.11348764598369598,
-0.34699466824531555,
0.06523231416940689,
-0.22445054352283478,
-0.18213680386543274,
-0.4393603801727295,
0.12070426344871521,
-0.08633635193109512,
-0.19293789565563202,
-6.115387439727783,
-0.23896051943302155,
-0.2356867790222168,
-0.3516539931297302,
-0.2697919011116028,
0.019748395308852196,
0.8534416556358337,
0.280785471200943,
0.31427714228630066,
0.31365934014320374,
0.9652652144432068,
0.5467803478240967,
0.17474506795406342,
-0.24463783204555511,
-0.30327194929122925,
0.43591395020484924,
-0.10694731026887894,
-0.37635931372642517,
-0.3753896951675415,
-0.012701197527348995,
0.04747115820646286,
-0.11918886750936508,
0.1930256187915802,
0.7121926546096802,
0.25474098324775696,
0.34811121225357056,
-0.4663398265838623,
0.27014097571372986,
-0.5697453618049622,
0.5016579031944275,
0.1845390498638153,
-0.6280012726783752,
-0.14436794817447662,
0.03179589658975601,
-0.41323304176330566,
0.20128118991851807,
0.19363349676132202,
-0.040765758603811264,
-0.22156555950641632,
-0.3927607536315918,
-0.11214302480220795,
-0.2383742332458496,
-0.01514500193297863,
-0.37599149346351624,
0.11455532163381577,
-0.02963401935994625,
0.1267973631620407,
-0.20009459555149078,
0.06912001222372055,
0.5721179246902466,
0.34191077947616577,
-0.26902732253074646,
-0.10825762152671814,
0.28008395433425903,
0.4241568148136139,
0.15035779774188995,
0.1277245283126831,
0.43552228808403015,
-0.18669858574867249,
0.07824604213237762,
0.10102707892656326,
-0.18425093591213226,
0.20989617705345154,
-0.2426052689552307,
0.45637109875679016,
0.4140040874481201,
-0.29734885692596436,
-0.7306569218635559,
0.6461262106895447,
-0.00566305173560977,
0.051539137959480286,
0.2686217725276947,
0.2063630372285843,
-0.613036572933197,
-0.2128576785326004,
-0.671833872795105,
0.06672074645757675,
-0.12871763110160828,
-0.049702469259500504,
-0.5003625154495239,
-0.5539780259132385,
-0.18964114785194397,
0.11460773646831512,
-0.7043741345405579,
0.19998691976070404,
0.061441898345947266,
0.40720710158348083,
-0.4724689722061157,
0.010010980069637299,
0.38561779260635376,
0.6194683909416199,
-0.3067452907562256,
-0.006280601490288973,
0.15552975237369537,
0.02677871286869049,
0.9653776288032532,
0.06325405836105347,
0.6161690950393677,
-0.026942050084471703,
-0.1633107215166092,
0.9269638061523438,
-0.476225346326828,
-0.27406612038612366,
-0.8507106304168701,
-0.0021958218421787024,
0.0252237468957901,
-0.09948378056287766,
0.2150917798280716,
1.0087380409240723,
-0.3485719561576843,
0.03130965679883957,
0.17968696355819702,
-0.2482045739889145,
-0.46510884165763855,
0.3341529071331024,
0.032215479761362076,
0.06690815091133118,
0.4493594169616699,
0.8259437680244446,
-0.11142844706773758,
0.3212100863456726,
0.3158360719680786,
-0.3848697543144226,
0.7627003192901611,
0.27955469489097595,
-0.20668768882751465,
0.11524564027786255,
0.5701571702957153,
0.10228234529495239,
-0.4413357079029083,
0.05609391629695892,
0.26656243205070496,
0.16984964907169342,
-0.13045457005500793,
0.3893700838088989,
0.1532045602798462,
-0.14087511599063873,
0.054326411336660385,
0.022634044289588928,
-0.06800952553749084,
-0.26662886142730713,
0.22005778551101685,
-0.5141571760177612,
-0.2230345606803894,
-0.46263548731803894,
0.037146542221307755,
-0.3642529249191284,
-0.27413251996040344,
0.09091794490814209,
0.22086387872695923,
0.2338918149471283,
0.015203308314085007,
-0.24732854962348938,
0.40423375368118286,
-0.7469046711921692,
0.10309085994958878,
0.6724153161048889,
0.16030745208263397,
-0.10494176298379898,
-0.38615408539772034,
0.14836789667606354,
-0.07177828252315521,
-0.7563031315803528,
-0.20556223392486572,
0.1473151594400406,
-0.09816185384988785,
0.4029204845428467,
-0.7341548204421997,
-0.14129005372524261,
0.435801237821579,
-0.045886192470788956,
-0.4615112543106079,
-0.1245739683508873,
0.2983541190624237,
0.12150034308433533,
0.25268080830574036,
-0.3135753273963928,
-0.02750915288925171,
0.034856293350458145,
0.6458614468574524,
0.12631891667842865,
-0.5354931950569153,
-0.3726770877838135,
0.4606284201145172,
-0.18246039748191833,
-0.07730266451835632,
0.22686614096164703,
-0.39317867159843445,
0.024153172969818115,
0.18702933192253113,
0.5526190996170044,
0.33826637268066406,
-0.003554866649210453,
0.2528013288974762,
0.06278505176305771,
-0.45429331064224243,
-0.5461480021476746,
0.03288484364748001,
-0.21676133573055267,
0.23311641812324524,
0.12185459583997726,
0.4952836334705353,
-0.11094076186418533,
-0.31877434253692627,
0.2610669434070587,
-0.17630332708358765,
-0.32008084654808044,
0.012775895185768604,
-0.054250989109277725,
-0.41418975591659546,
-0.06114650517702103,
0.02477136440575123,
-0.23604777455329895,
0.7755778431892395,
0.10645662248134613,
-0.10734932124614716,
-0.18105366826057434,
-0.6908561587333679,
-0.07964441180229187,
0.34049850702285767,
-0.013132807798683643,
0.19205833971500397,
-0.388675332069397,
-0.26710182428359985,
-0.28545746207237244,
0.6980403661727905,
0.1383676677942276,
-1.148513913154602,
0.06834843754768372,
0.09202723950147629,
-0.1553066521883011,
-0.28054895997047424,
0.08692547678947449,
0.6536847352981567,
-0.43073171377182007,
0.04759543761610985,
0.20121578872203827,
-0.10165093839168549,
0.07883608341217041,
0.19734564423561096,
-0.07884299755096436,
0.38883528113365173,
-0.14519375562667847,
-0.4435761570930481,
-0.03662542626261711,
-0.3725844621658325,
0.019885951653122902,
-0.5945833921432495,
0.24667111039161682,
0.20163774490356445,
-0.46241244673728943,
-0.39795079827308655,
0.3037719428539276,
-0.1130678802728653,
0.507500171661377,
-0.005447259172797203,
0.19520989060401917,
-0.2686532735824585,
-0.09984375536441803,
-0.377704381942749,
-0.25090986490249634,
0.1321042776107788,
-0.5717574954032898,
0.059037063270807266,
0.19262821972370148,
-0.23919129371643066,
-0.5242615342140198,
-0.42021188139915466,
0.012832531705498695,
-0.2823208272457123,
0.022170426324009895,
-0.1551235318183899,
0.3813897967338562,
0.31726938486099243,
0.43632110953330994,
0.11381494253873825,
-0.35707512497901917,
0.07270748168230057,
-0.22557643055915833,
0.4694547951221466,
-0.2412937432527542,
-0.3980976939201355,
0.24851958453655243,
-0.13719047605991364,
0.4119551479816437,
-0.6471361517906189,
-0.2521892189979553,
-0.3608681559562683,
-0.15091769397258759,
-0.40374937653541565,
0.14776454865932465,
0.3232381343841553,
-0.24568870663642883,
-0.27882301807403564,
0.14520232379436493,
0.10711411386728287,
-0.041595686227083206,
0.5612018704414368,
-0.3875199854373932,
-0.1567317694425583,
-0.6641497611999512,
0.18082375824451447,
0.10621914267539978,
-0.4076245129108429,
-0.0625082328915596,
0.0483015812933445,
0.3201581835746765,
0.49967536330223083,
-0.6068301200866699,
0.07806510478258133,
0.44524678587913513,
-0.21807068586349487,
0.05786993354558945,
0.4015733003616333,
-0.7460001111030579,
0.4608982503414154,
-0.15103496611118317,
-0.20424044132232666,
0.08844079822301865,
-0.1890610307455063,
0.36162835359573364,
0.3937965929508209,
-0.0964566096663475,
-0.12711158394813538,
-0.1314786821603775,
0.3108508586883545,
-0.1324564516544342,
0.4875527024269104,
0.0914047360420227,
0.3350583612918854,
0.5630000829696655,
0.3504756987094879,
-0.20845642685890198,
0.10020021349191666,
-0.045435547828674316,
0.13184504210948944,
0.019699931144714355,
-0.5312791466712952,
-0.4127955734729767,
0.27606216073036194,
0.9595515727996826,
0.18400394916534424,
-0.019180044531822205,
0.1454639583826065,
0.18021437525749207,
0.09264820069074631,
0.3031052350997925,
0.1467558890581131,
0.20678633451461792,
-0.010310904122889042,
0.5905810594558716,
-0.04469182342290878,
0.416103720664978,
0.5161142349243164,
-0.12527205049991608,
-0.18960581719875336,
-0.07414442300796509,
0.10146918892860413,
-0.4457552134990692,
-0.24861669540405273,
0.31604987382888794,
0.02818943001329899,
0.11124971508979797,
0.07189050316810608,
0.37616991996765137,
-0.07865630090236664,
0.2944251596927643,
-0.11355920881032944,
-0.2549266815185547,
-0.28732985258102417,
-0.03596433252096176,
-0.31892749667167664,
-0.6470993161201477,
0.24317649006843567,
0.4182325303554535,
0.004742597229778767,
0.2520262897014618,
0.26621168851852417,
0.29845237731933594,
0.42582374811172485,
-0.46977362036705017,
0.050531093031167984,
-0.05770239979028702,
-0.5041041374206543,
-0.3855816423892975,
0.07071808725595474,
-0.44436994194984436,
0.19353142380714417,
0.08560831844806671,
-0.22872035205364227,
-0.052252013236284256,
-0.2604627013206482,
-0.31270909309387207,
0.2721472978591919,
0.317696750164032,
-0.40302401781082153,
0.20450253784656525,
0.4879714846611023,
0.0483265183866024,
0.07270503789186478,
-0.10541804134845734,
-0.1898127943277359,
-0.3105942904949188,
0.2990749180316925,
-0.10161711275577545,
0.27010980248451233,
-0.3138822019100189,
0.14785057306289673,
-0.5147003531455994,
0.20981168746948242,
0.48297107219696045,
0.27352115511894226,
-0.3393420875072479,
0.049045123159885406,
-0.4937267005443573,
-0.11753339320421219,
0.6694630980491638,
-0.5142533779144287,
-0.0665692389011383,
-0.8166590929031372,
-0.28106704354286194,
-0.40556800365448,
0.06762825697660446,
0.1847664713859558,
-0.029613865539431572,
0.029262427240610123,
0.4997698962688446,
0.39852553606033325,
-0.17070144414901733,
0.9634807109832764,
-0.13432306051254272,
0.16356933116912842,
-0.5046507716178894,
0.019088491797447205,
-0.4188443422317505,
-0.12399429827928543,
0.48859772086143494,
0.008820844814181328,
0.32709378004074097,
0.05832650884985924,
0.1991966962814331,
-0.1118319183588028,
0.42871594429016113,
0.059935685247182846,
0.3114893436431885,
-0.24468857049942017,
-0.05018872022628784,
-0.03753955289721489,
-0.45807531476020813,
0.31628158688545227,
0.11820349097251892,
0.5347294807434082,
-0.15782222151756287,
-0.12390213459730148,
0.20053519308567047,
0.22879377007484436,
0.27589476108551025,
-0.4363496005535126,
0.02902253344655037,
0.024457553401589394
] |
Groundnut bud necrosis virus (GBNV), a member of genus Tospovirus in the family Bunyaviridae, infects a large number of leguminosae and solanaceae plants in India. With a view to elucidate the function of nonstructural protein, NSs encoded by the small RNA genome (S RNA), the NSs protein of GBNV- tomato (Karnataka) [1] was over-expressed in E. coli and purified by Ni-NTA chromatography. The purified rNSs protein exhibited an RNA stimulated NTPase activity. Further, this activity was metal ion dependent and was inhibited by adenosine 5′ (β, γ imido) triphosphate, an ATP analog. The rNSs could also hydrolyze dATP. Interestingly, in addition to the NTPase and dATPase activities, the rNSs exhibited ATP independent 5′ RNA/DNA phosphatase activity that was completely inhibited by AMP. The 5′ α phosphate could be removed from ssDNA, ssRNA, dsDNA and dsRNA thus confirming that rNSs has a novel 5′ α phosphatase activity. K189A mutation in the Walker motif A (GxxxxGKT) resulted in complete loss of ATPase activity, but the 5′ phosphatase activity was unaffected. On the other hand, D159A mutation in the Walker motif B (DExx) resulted in partial loss of both the activities. These results demonstrate for the first time that NSs is a bifunctional enzyme, which could participate in viral movement, replication or in suppression of the host defense mechanism. | [
-0.0069559477269649506,
-0.0051087262108922005,
0.009378323331475258,
0.021192457526922226,
-0.0220709927380085,
0.005141330882906914,
0.008062999695539474,
0.007369192782789469,
-0.01187002845108509,
0.0177103690803051,
-0.013164169155061245,
0.01284204050898552,
-0.002925500739365816,
0.013382229954004288,
-0.009554056450724602,
0.02151198871433735,
-0.0018155437428504229,
0.008246440440416336,
0.011607500724494457,
0.004710729233920574,
-0.012095912359654903,
-0.006069478113204241,
0.008095158264040947,
-0.009494117461144924,
0.012923058122396469,
0.030292462557554245,
0.0006550825200974941,
0.0056187803857028484,
-0.010519285686314106,
0.01376090757548809,
0.0044083986431360245,
0.018604271113872528,
0.02883472479879856,
0.0041168504394590855,
0.0006485285703092813,
-0.011609764769673347,
-0.007681484334170818,
0.021386640146374702,
0.011011328548192978,
-0.00564691424369812,
0.019988279789686203,
-0.009112787432968616,
0.0023951372131705284,
-0.027075450867414474,
-0.00721790362149477,
-0.03592807799577713,
0.0007484090165235102,
0.00759311905130744,
0.005086436867713928,
0.0036107853520661592,
-0.00983339548110962,
-0.008250166662037373,
-0.012374196201562881,
0.0074040391482412815,
-0.005040481686592102,
0.003282673191279173,
0.013393758796155453,
0.029920343309640884,
-0.013231156393885612,
-0.01127071026712656,
0.02305622771382332,
0.019535865634679794,
-0.019959330558776855,
0.013726826757192612,
0.02148730307817459,
-0.06683333963155746,
0.02414090186357498,
-0.0009458418935537338,
-0.01121697947382927,
0.007428311742842197,
0.004488863982260227,
0.0075425757095217705,
-0.006119749508798122,
-0.016699323430657387,
-0.0052600945346057415,
-0.00839240476489067,
-0.02673027291893959,
0.004807925783097744,
-0.004375840071588755,
0.02347913198173046,
0.013720421120524406,
0.0015558423474431038,
-0.0026755421422421932,
0.014456937089562416,
0.013494638726115227,
-0.0007637564558535814,
-0.027993451803922653,
-0.04214773699641228,
0.00495466124266386,
0.011900327168405056,
0.04289638251066208,
-0.023204347118735313,
-0.0024288929998874664,
0.0033256285823881626,
0.00919259525835514,
-0.0030563510954380035,
-0.010299455374479294,
-0.019921574741601944,
-0.005896998569369316,
-0.017845846712589264,
-0.00591658428311348,
0.019250843673944473,
0.008622808381915092,
0.01604604721069336,
0.00048004090785980225,
0.00003311230830149725,
0.029096532613039017,
0.0016595814377069473,
0.028439857065677643,
0.010457979515194893,
0.010969409719109535,
-0.010206014849245548,
-0.011787324212491512,
0.03384833782911301,
0.012413355521857738,
0.03867204487323761,
-0.007950186729431152,
-0.016581658273935318,
0.004351941868662834,
0.0019768867641687393,
0.0019167745485901833,
0.0006353124044835567,
-0.017739063128829002,
-0.005116642452776432,
0.007307570427656174,
0.008566584438085556,
-0.006394820287823677,
-0.010127723217010498,
0.017450015991926193,
-0.008955472148954868,
-0.004337417893111706,
-0.00814526341855526,
-0.027603253722190857,
-0.017186569049954414,
-0.00928098801523447,
-0.011588620021939278,
-0.0011038859374821186,
0.013348042033612728,
0.0006170952692627907,
-0.003079756163060665,
0.012900954112410545,
0.005346900783479214,
0.01082587894052267,
0.0015256718033924699,
0.010062762536108494,
0.0027717342600226402,
0.011044934391975403,
0.0025136976037174463,
-0.005630937870591879,
-0.016772132366895676,
-0.00007401045877486467,
-0.00368660781532526,
0.0002371587324887514,
-0.002372968476265669,
0.020669549703598022,
0.009051352739334106,
-0.01985660009086132,
-0.03983699902892113,
-0.003952409140765667,
0.02076910436153412,
0.018981847912073135,
-0.03561887890100479,
0.022779593244194984,
0.007224338129162788,
0.0018622661009430885,
-0.011874598450958729,
0.004578705877065659,
-0.006105008535087109,
-0.012627754360437393,
0.00875903107225895,
0.0028057750314474106,
0.00025087175890803337,
0.007444523274898529,
0.012622980400919914,
-0.010989399626851082,
-0.005013428628444672,
0.029466595500707626,
0.0044723814353346825,
-0.01910054311156273,
0.06627686321735382,
0.0014089124742895365,
0.021477757021784782,
0.0004743549507111311,
0.013423159718513489,
0.010527551174163818,
-0.006863418035209179,
0.016353566199541092,
-0.004949489608407021,
-0.02503376640379429,
0.0015825508162379265,
0.002440823707729578,
0.020805438980460167,
-0.01425890438258648,
0.024840230122208595,
0.005987419281154871,
0.0022314738016575575,
0.02805342525243759,
-0.0036378500517457724,
0.016351528465747833,
0.03345585614442825,
-0.0033288937993347645,
-0.007662005256861448,
-0.012127312831580639,
-0.015187209472060204,
-0.02500915341079235,
0.016802579164505005,
0.0034104688093066216,
0.009970132261514664,
-0.009192290715873241,
-0.009977594017982483,
0.006541647017002106,
-0.03454788774251938,
-0.01580214872956276,
-0.014678020030260086,
-0.02110544592142105,
0.003999277018010616,
0.0012643705122172832,
0.044883668422698975,
-0.007053627632558346,
-0.0057984902523458,
-0.008707950823009014,
-0.002397262491285801,
0.0022256155498325825,
-0.010693920776247978,
0.024019312113523483,
0.0013352520763874054,
0.022233713418245316,
0.0076982625760138035,
-0.0006679586367681623,
0.010695090517401695,
0.004698658362030983,
-0.029868295416235924,
-0.012087063863873482,
0.0033515654504299164,
0.023675434291362762,
0.011667399667203426,
0.012065505608916283,
-0.015403008088469505,
-0.004676610231399536,
-0.012382788583636284,
0.009709603153169155,
0.009977811947464943,
0.02137162908911705,
0.014135254546999931,
0.01420991588383913,
-0.0041207205504179,
0.0020227208733558655,
0.009141676127910614,
-0.004959399811923504,
-0.014150233939290047,
0.01011964213103056,
0.02248399332165718,
0.018511418253183365,
-0.019497420638799667,
-0.005396037828177214,
-0.005348940379917622,
0.022040393203496933,
-0.0027268659323453903,
0.022462520748376846,
-0.008701561018824577,
0.004653602372854948,
0.006692591588944197,
0.028680745512247086,
0.01586647517979145,
-0.02711256593465805,
0.02071000263094902,
0.008761957287788391,
-0.011935092508792877,
-0.005301160737872124,
0.00998665951192379,
0.011645367369055748,
-0.011254606768488884,
0.004850037861615419,
-0.08156653493642807,
-0.0026118350215256214,
0.008533043786883354,
-0.006114175543189049,
0.005882691126316786,
0.016222946345806122,
0.026797322556376457,
-0.008754504844546318,
-0.013251197524368763,
0.0016754334792494774,
-0.004589080344885588,
-0.017454901710152626,
-0.006548768375068903,
0.013389413245022297,
0.027284370735287666,
-0.009923083707690239,
0.013031904585659504,
-0.02905057743191719,
-0.02949255146086216,
-0.006875487044453621,
0.030661504715681076,
-0.0344497412443161,
0.030434884130954742,
-0.009821910411119461,
-0.005959887057542801,
0.04483263939619064,
-0.002527065807953477,
-0.003331055399030447,
-0.009449154138565063,
0.00011151086073368788,
-0.009963632561266422,
0.009995348751544952,
0.014157203957438469,
-0.010847989469766617,
0.051000338047742844,
0.007643684279173613,
-0.024441545829176903,
-0.008295619860291481,
-0.0003870854852721095,
0.024470306932926178,
-0.01731959357857704,
0.007638086564838886,
-0.004654145799577236,
-0.002182670636102557,
0.009902345016598701,
0.004180124029517174,
0.02912347950041294,
0.00611767265945673,
0.019379429519176483,
0.0019437443697825074,
-0.010538691654801369,
0.006614340469241142,
0.024503175169229507,
0.013363898731768131,
-0.009323839098215103,
0.014994189143180847,
0.017958931624889374,
0.003962044138461351,
-0.001324560958892107,
0.005087070632725954,
-0.01760673336684704,
0.011314718052744865,
-0.003936744295060635,
-0.029559563845396042,
0.012487288564443588,
0.013092901557683945,
0.019864022731781006,
0.007518423721194267,
-0.032075896859169006,
0.014072354882955551,
-0.00041589909233152866,
0.020644284784793854,
-0.0013730782084167004,
-0.005947026424109936,
-0.020650945603847504,
-0.005805802531540394,
-0.010262488387525082,
-0.013631043024361134,
0.0026889145374298096,
-0.011587921530008316,
-0.01660342887043953,
0.021902965381741524,
-0.006969250738620758,
-0.012866783887147903,
0.004812810570001602,
-0.013536570593714714,
0.012062334455549717,
0.017162244766950607,
0.014410821720957756,
-0.01592707633972168,
0.012191549874842167,
0.014339614659547806,
-0.01818789169192314,
0.01221071183681488,
-0.03156343102455139,
-0.022478986531496048,
0.002089729532599449,
0.023176399990916252,
-0.0035715089179575443,
0.004941166378557682,
-0.0072756605222821236,
-0.008222789503633976,
0.024736803025007248,
-0.006346909329295158,
-0.03278272598981857,
0.009874907322227955,
0.005204887129366398,
0.012924907729029655,
-0.002883280161768198,
0.005345035344362259,
0.00824553333222866,
0.00875537283718586,
-0.006231040693819523,
-0.00552085367962718,
0.010923036374151707,
-0.031927917152643204,
-0.002150813117623329,
-0.014255719259381294,
0.07244119048118591,
-0.008052628487348557,
0.017735343426465988,
-0.012218768708407879,
-0.020025642588734627,
-0.00644421624019742,
0.0018131481483578682,
0.002143385587260127,
-0.03073113039135933,
-0.02375531569123268,
0.010075735859572887,
0.00708812614902854,
-0.004034463316202164,
0.007240882143378258,
0.010302670300006866,
0.017662281170487404,
0.021970953792333603,
0.004109792411327362,
-0.006877002771943808,
0.014767128974199295,
0.014507352374494076,
-0.02980809286236763,
-0.024142371490597725,
-0.0027440490666776896,
-0.003743085078895092,
-0.006266755051910877,
0.023614399135112762,
-0.009715551510453224,
-0.00996778067201376,
0.014566870406270027,
0.0001143747940659523,
-0.010442040860652924,
-0.011236261576414108,
-0.0029142554849386215,
0.03274837136268616,
-0.007698702625930309,
0.004362644627690315,
-0.0009591756388545036,
0.012521347030997276,
-0.009720548056066036,
-0.011145239695906639,
-0.015906916931271553,
0.023493366315960884,
0.006963540334254503,
-0.02294953353703022,
0.0069146170280873775,
0.009236382320523262,
-0.0030348680447787046,
0.0000154874287545681,
-0.004374101758003235,
0.012662336230278015,
0.000009200535714626312,
0.00687875971198082,
-0.0018085769843310118,
0.002831469289958477,
-0.03353036940097809,
-0.004804319702088833,
-0.0019999754149466753,
0.018474042415618896,
0.02155882865190506,
0.009255023673176765,
-0.031921178102493286,
-0.013555929064750671,
-0.005265484098345041,
0.01534181833267212,
-0.018660960718989372,
-0.0021100416779518127,
0.0018768555019050837,
-0.0024902326986193657,
-0.01588575169444084,
-0.0050203618593513966,
0.008496495895087719,
-0.020191706717014313,
0.0038926107808947563,
0.0007270453497767448,
0.005352144129574299,
0.0017944846767932177,
0.0296250618994236,
0.012086894363164902,
-0.019998542964458466,
0.020044591277837753,
0.02810961753129959,
-0.009636910632252693,
-0.0016149135772138834,
0.030871666967868805,
0.030354678630828857,
0.005428331438452005,
-0.074898362159729,
-0.009123261086642742,
0.007260533049702644,
0.0017994376830756664,
0.010749882087111473,
-0.01625407487154007,
-0.014126133173704147,
0.0009210552088916302,
-0.026156354695558548,
-0.006952340714633465,
0.03688180446624756,
-0.007872452959418297,
0.04005832225084305,
-0.005997589323669672,
0.011536972597241402,
0.010228851810097694,
-0.010110360570251942,
-0.0037750545889139175,
-0.004993883892893791,
-0.004187008365988731,
-0.013230999000370502,
0.04131956771016121,
-0.023719293996691704,
-0.005919856019318104,
-0.006540138274431229,
-0.08150270581245422,
-0.02166479080915451,
0.020953932777047157,
-0.0038780567701905966,
-0.013328224420547485,
-0.012789980508387089,
0.0015114489942789078,
-0.015813710168004036,
0.009846268221735954,
-0.011332565918564796,
0.016525542363524437,
0.017735768109560013,
-0.0021599563769996166,
-0.011164558120071888,
-0.013645615428686142,
-0.01133008860051632,
0.01750389114022255,
-0.0058708409778773785,
0.002350237686187029,
0.012001610361039639,
-0.010956736281514168,
-0.0004557317588478327,
-0.006045978516340256,
-0.01318372879177332,
-0.010334376245737076,
-0.004977574571967125,
-0.0031145827379077673,
0.014091473072767258,
0.009937969036400318,
-0.009852278977632523,
-0.009421407245099545,
0.0005516252713277936,
-0.014142169617116451,
-0.04243345931172371,
0.00019872654229402542,
-0.008993868716061115,
0.03750220313668251,
-0.008517465554177761,
0.03136854246258736,
-0.012554616667330265,
-0.003040880896151066,
0.005251008085906506,
0.020406976342201233,
0.030178438872098923,
0.0007140408270061016,
0.010676666162908077,
0.006728099659085274,
-0.013163385912775993,
0.004799462854862213,
-0.00334534770809114,
-0.0011649655643850565,
-0.0062032425776124,
-0.00048793014138936996,
0.00998133234679699,
0.004880585242062807,
0.00416967086493969,
-0.0020799292251467705,
0.006855007726699114,
0.007321207318454981,
0.013889104127883911,
-0.006226920522749424,
-0.000298389233648777,
0.01450739149004221,
0.07144598662853241,
0.0026759030297398567,
0.007250055205076933,
0.009591816924512386,
0.009549733251333237,
0.007727522403001785,
-0.011287873610854149,
0.016131583601236343,
0.00801268219947815,
0.008961450308561325,
0.013284779153764248,
-0.0008945446461439133,
0.000283936969935894,
0.011073498986661434,
-0.000024574575945734978,
-0.005356666631996632,
-0.02138977125287056,
-0.010839330032467842,
-0.00287266680970788,
-0.011706136167049408,
0.006553834304213524,
0.01346351858228445,
0.012269045226275921,
-0.020591728389263153,
0.001901415642350912,
-0.019986089318990707,
0.010720367543399334,
-0.0050729247741401196,
-0.04772493988275528,
0.0011757296742871404,
0.010251646861433983,
-0.0030193431302905083,
0.006176727823913097,
0.0025022272020578384,
0.012677740305662155,
0.004096366465091705,
-0.009193205274641514,
0.012954351492226124,
-0.009123354218900204,
-0.018010828644037247,
0.014546068385243416,
-0.010885391384363174,
-0.005619768053293228,
-0.00799616239964962,
0.007902143523097038,
-0.013164438307285309,
0.011046381667256355,
0.03090476617217064,
-0.008572560735046864,
0.019859207794070244,
0.027459068223834038,
0.012646296061575413,
0.008689447306096554,
0.03607496619224548,
0.008135633543133736,
-0.020889615640044212,
-0.01590321771800518,
-0.001025539357215166,
0.022709069773554802,
0.014784341678023338,
0.01247391477227211,
-0.00943714939057827,
-0.013941937126219273,
-0.016706466674804688,
0.014652879908680916,
-0.013974381610751152,
-0.011183392256498337,
-0.020459474995732307,
-0.006486815400421619,
0.009722253307700157,
0.020937446504831314,
-0.029942940920591354,
0.011635471135377884,
-0.0005633500404655933,
0.016714872792363167,
0.013173433020710945,
-0.002067709807306528,
-0.011382916942238808,
0.013375005684792995,
0.003961856476962566,
-0.009808117523789406,
-0.033106040209531784,
0.0007168455049395561,
0.005524985026568174,
0.004271848127245903,
-0.005679796915501356,
-0.02454189769923687,
0.021260254085063934,
0.002219216199591756,
0.004533576313406229,
0.011146977543830872,
-0.0018729866715148091,
0.012795697897672653,
0.006123685277998447,
0.011142210103571415,
0.03295118361711502,
0.004495738074183464,
0.0013009761460125446,
0.00548793189227581,
0.012231565080583096,
0.03136856108903885,
-0.012051135301589966,
0.005028354004025459,
0.013848873786628246,
0.006601807661354542,
-0.0002510122722014785,
0.010257875546813011,
0.004776052664965391,
0.007934027351439,
0.029265297576785088,
0.00824660062789917,
-0.010585682466626167,
0.0014502985868602991,
0.01341226976364851,
0.0035397778265178204,
0.009898870252072811,
-0.022515492513775826,
0.008885296992957592,
-0.02176067605614662,
-0.014866679906845093,
-0.011286921799182892,
-0.016645647585392,
0.022423062473535538,
0.02675984799861908,
-0.015466567128896713,
-0.010328510776162148,
-0.01016543060541153,
0.004127946216613054,
-0.0022621892858296633,
0.000780999194830656,
0.025576278567314148,
-0.026301492005586624,
0.00927688553929329,
0.0036677513271570206,
0.0005469537572935224,
0.029371611773967743,
0.031939104199409485,
-0.01956009864807129,
0.0002840133383870125,
0.004611298441886902,
-0.004585016518831253,
-0.011782912537455559,
0.003701184643432498,
-0.00007354328408837318,
0.006572552025318146,
-0.024743899703025818,
0.03928110748529434,
0.02460717037320137,
0.0071948738768696785,
0.002896388992667198,
0.01568525843322277,
-0.0005575795657932758,
0.0008331798017024994,
-0.00838976539671421,
0.00884467363357544,
-0.002569466130807996,
-0.002751775551587343,
-0.00907458271831274,
0.0054817209020257,
0.02660365030169487,
0.008432433009147644,
0.005763184744864702,
0.03185618296265602,
-0.0077179549261927605,
0.007424833253026009,
0.02574929967522621,
0.008137228898704052,
0.004561888985335827,
-0.004193627275526524,
0.033817362040281296,
0.010677918791770935,
-0.004970864858478308,
0.023962605744600296,
0.011328980326652527,
-0.007561374455690384,
-0.0034657425712794065,
-0.007150277961045504,
-0.027571599930524826,
0.006955617107450962,
0.01542939618229866,
-0.011559590697288513,
0.006684739608317614,
-0.003685013623908162,
-0.007802976761013269,
-0.010877794586122036,
-0.00612877681851387,
-0.005253717303276062,
-0.0005647740326821804,
-0.013125359080731869,
0.01720663160085678,
-0.021738488227128983,
0.012528497725725174,
0.005600200034677982,
-0.00030341302044689655,
0.029504021629691124,
0.0044140806421637535,
-0.0034357821568846703,
0.0037411346565932035,
0.02211686782538891,
0.012468688189983368,
0.024968992918729782,
-0.007840115576982498
] | [
-0.06891044974327087,
-0.10258311778306961,
-0.24960853159427643,
0.05976458638906479,
0.07974540442228317,
-0.22132807970046997,
0.14897799491882324,
0.7595018744468689,
0.10840731114149094,
-0.2825566232204437,
0.0352608859539032,
-0.1210484653711319,
-0.5766496658325195,
0.43720895051956177,
0.026522595435380936,
0.8808491826057434,
0.501716673374176,
0.04294823482632637,
-0.1855044662952423,
-0.24819307029247284,
-0.0304213035851717,
-0.6813825368881226,
0.5000893473625183,
0.27852439880371094,
-0.12582038342952728,
0.293044775724411,
0.5634730458259583,
0.6020117998123169,
0.4667048454284668,
-0.6629003286361694,
0.13759203255176544,
0.8507592082023621,
0.6868865489959717,
-0.1271209418773651,
-0.17181415855884552,
-0.05440383031964302,
-0.40716812014579773,
0.08869452029466629,
0.2771921157836914,
-0.44623124599456787,
-0.370814710855484,
-0.4617800712585449,
-0.11459669470787048,
0.22629524767398834,
0.10042500495910645,
-0.49615049362182617,
-0.9650344848632812,
1.4333248138427734,
-0.5231157541275024,
0.065189890563488,
-0.10821257531642914,
0.5755971670150757,
0.2888071537017822,
-0.45291662216186523,
0.6457541584968567,
0.4426615536212921,
-0.512721836566925,
0.09223569184541702,
0.20688079297542572,
-0.7174798846244812,
0.07254188507795334,
-0.08811453729867935,
-0.17144235968589783,
0.33052825927734375,
-0.4586239159107208,
0.8702608346939087,
-0.21835044026374817,
0.24109254777431488,
-0.193414106965065,
0.012304837815463543,
-0.2387998104095459,
-0.36400750279426575,
0.011185679584741592,
0.4748392701148987,
0.23987527191638947,
-0.16135729849338531,
-0.6129360198974609,
-0.38644203543663025,
0.14574123919010162,
-0.08472823351621628,
-0.43078476190567017,
-0.3689083755016327,
0.19086816906929016,
-0.2880413234233856,
0.2831035554409027,
-0.0367560051381588,
0.002218842739239335,
0.62431401014328,
-0.5494577884674072,
0.3438272774219513,
-0.2838577628135681,
0.5282770991325378,
0.7162618041038513,
0.21000540256500244,
-0.0956183448433876,
0.07811910659074783,
-0.18726566433906555,
0.14007507264614105,
0.8997572064399719,
0.15282535552978516,
-0.24288111925125122,
-0.06211651861667633,
-0.1600293219089508,
0.17263786494731903,
-0.48829415440559387,
0.6852508187294006,
-0.015307189896702766,
-0.47256022691726685,
-0.7595304846763611,
0.15893536806106567,
-0.3128015995025635,
0.16950881481170654,
-0.44482988119125366,
-0.24431933462619781,
-0.18896634876728058,
-0.099162258207798,
-0.23066402971744537,
-0.6639084219932556,
-0.2653820216655731,
-0.0626758560538292,
-0.7683317065238953,
0.8109615445137024,
-0.2953021228313446,
0.6141507625579834,
0.18527449667453766,
0.024344705045223236,
-0.29305654764175415,
-0.015626709908246994,
-0.13880053162574768,
0.9405554533004761,
0.726729691028595,
0.5681131482124329,
-0.40252789855003357,
-0.37829965353012085,
-0.03376545011997223,
-0.17645713686943054,
-0.23405632376670837,
-0.27153050899505615,
0.5733985304832458,
0.055052559822797775,
-1.0054397583007812,
-0.20632438361644745,
-0.23481041193008423,
0.2636137306690216,
0.04481909051537514,
-0.02242422103881836,
-0.2487776279449463,
0.12991751730442047,
-0.25945621728897095,
-0.46853843331336975,
0.6210312247276306,
-0.1325293928384781,
-1.0021125078201294,
0.002196486108005047,
-0.09019196778535843,
0.46651574969291687,
-0.586211621761322,
-0.16243018209934235,
-0.3071354925632477,
0.8161076903343201,
0.21220996975898743,
-0.07993951439857483,
-0.08892138302326202,
0.20317743718624115,
0.09648918360471725,
-0.10878700762987137,
0.30355116724967957,
0.12074798345565796,
0.11606303602457047,
-0.1796717345714569,
-0.4207057058811188,
-0.5047901272773743,
-0.027601221576333046,
-0.7140827775001526,
0.22559037804603577,
0.11215641349554062,
-0.08897676318883896,
-0.7377637028694153,
0.46701180934906006,
0.28221550583839417,
-0.7260438203811646,
0.31401944160461426,
-0.05467905104160309,
0.12104640156030655,
-0.22440528869628906,
0.12316782027482986,
0.14053891599178314,
0.2394261658191681,
0.4813055396080017,
0.3637676537036896,
-0.8756406903266907,
-0.15241384506225586,
0.8179097175598145,
-0.516852080821991,
1.7051208019256592,
0.21317440271377563,
-0.1745445877313614,
1.1127651929855347,
0.47717776894569397,
-0.1914239525794983,
-0.36671897768974304,
0.3814839720726013,
0.7315923571586609,
-0.6976574063301086,
-0.6583811044692993,
0.12847071886062622,
-0.15297672152519226,
-0.21102812886238098,
0.6789409518241882,
-0.111597441136837,
0.007388733327388763,
-0.5885792970657349,
0.06238710507750511,
-0.45933961868286133,
0.7123422026634216,
-0.09050791710615158,
-0.2677074372768402,
0.0746641680598259,
0.47768285870552063,
-0.37449735403060913,
0.03766871988773346,
-0.34184402227401733,
0.4029713273048401,
0.6976788640022278,
0.018607793375849724,
0.943021297454834,
0.43593141436576843,
0.16226689517498016,
0.7606028914451599,
-0.22665166854858398,
0.5342401266098022,
-0.15315952897071838,
0.5233175158500671,
-0.5100165009498596,
0.004254752770066261,
0.34651291370391846,
0.09992388635873795,
-0.05297777056694031,
0.2737213671207428,
0.3849250078201294,
-0.2229556441307068,
0.9095576405525208,
-0.7159340381622314,
-0.5958133339881897,
-0.2809814214706421,
-0.3561174273490906,
-0.48352229595184326,
-0.3474714159965515,
-0.4713705778121948,
-0.15405619144439697,
0.5311257839202881,
0.693875789642334,
0.44160011410713196,
-0.002098262310028076,
0.0836460143327713,
0.5372995138168335,
-0.21088333427906036,
0.01072766911238432,
0.454818993806839,
-0.16880573332309723,
-0.7523283958435059,
-0.2907538115978241,
-0.16244305670261383,
0.7648956179618835,
-0.2516152560710907,
-0.09432138502597809,
-0.21229182183742523,
-0.13609571754932404,
0.6345682144165039,
0.39684218168258667,
0.5557773113250732,
-0.19191499054431915,
-0.29278701543807983,
0.10067137330770493,
-0.06488050520420074,
-0.40363824367523193,
0.2047313004732132,
0.9770726561546326,
-0.5771061778068542,
-0.3997301757335663,
-0.5934908390045166,
-0.3301953673362732,
0.6091046333312988,
-0.590064525604248,
0.1849048137664795,
0.1001412644982338,
-0.25001367926597595,
-0.06212684512138367,
-0.9676250219345093,
-0.3762577772140503,
-0.43334051966667175,
0.6641882061958313,
-0.10822049528360367,
0.880794107913971,
0.18937718868255615,
-0.22687269747257233,
0.03509881719946861,
-0.11189831048250198,
0.6564264297485352,
-0.5680012106895447,
0.246046245098114,
0.2688635587692261,
-0.6784411668777466,
-0.1914578080177307,
-0.34387800097465515,
0.17274560034275055,
-0.21316295862197876,
-0.14348448812961578,
-5.546529293060303,
0.19533900916576385,
-0.26705536246299744,
-0.45788344740867615,
0.2138856202363968,
-0.5025162100791931,
0.5868232250213623,
-0.08639436960220337,
0.5157155990600586,
0.056120213121175766,
0.3363826274871826,
0.07856389880180359,
0.22203429043293,
-0.6604971289634705,
-0.30226007103919983,
0.2701859474182129,
0.2680746018886566,
-0.7146010994911194,
0.4424861669540405,
0.33404260873794556,
0.45386162400245667,
-0.1396399289369583,
-0.09268074482679367,
0.4729161560535431,
-0.3873422145843506,
0.5509346723556519,
-0.48078787326812744,
-0.050198618322610855,
-0.3395368158817291,
-0.18758822977542877,
0.5707839727401733,
-1.003312110900879,
0.3415925204753876,
0.02779838815331459,
-0.5973836183547974,
-0.4230501055717468,
-0.11609432846307755,
-0.4539679288864136,
-0.21137845516204834,
0.25347965955734253,
0.029659664258360863,
-0.25946271419525146,
0.025586601346731186,
0.16312575340270996,
0.3989205062389374,
-0.35559728741645813,
-0.10640517622232437,
-0.05224991217255592,
-0.6602689027786255,
1.2474913597106934,
0.575583815574646,
-0.34971949458122253,
0.002685306826606393,
0.5720057487487793,
0.18322938680648804,
0.10471165925264359,
0.008688525296747684,
0.17895972728729248,
-0.504968523979187,
0.031916409730911255,
-0.6661703586578369,
0.26792338490486145,
-0.4543464183807373,
-0.5915825963020325,
0.588346540927887,
0.4497291147708893,
-0.49092400074005127,
0.10816016793251038,
0.2061445116996765,
-0.30476000905036926,
-0.28718656301498413,
0.17887763679027557,
0.1838928461074829,
-0.5654935240745544,
0.46760016679763794,
-0.6507884860038757,
-0.16828949749469757,
-0.24546456336975098,
-0.2524758279323578,
-0.1836770921945572,
0.03132076561450958,
-0.3869432806968689,
-0.07834232598543167,
-0.4015355110168457,
0.15159282088279724,
-0.40875136852264404,
-0.10586604475975037,
-0.22136779129505157,
-0.033297669142484665,
-0.21864034235477448,
1.108010172843933,
-0.4011693000793457,
0.4169827401638031,
0.49646255373954773,
0.4421928822994232,
0.6997911930084229,
0.10294913500547409,
0.8275439739227295,
0.15607577562332153,
-0.2754577100276947,
1.2273058891296387,
-0.8047569990158081,
-0.09166689217090607,
-0.5954135656356812,
-0.2711546719074249,
0.0029743046034127474,
0.06749241799116135,
-0.06623724848031998,
0.7142025828361511,
-0.5835528373718262,
0.5910048484802246,
-0.3031906187534332,
-0.61699378490448,
-0.0022664994467049837,
0.510429859161377,
-0.19666126370429993,
0.2905410826206207,
0.39856719970703125,
0.28989166021347046,
-0.15233291685581207,
0.5744408965110779,
0.25037139654159546,
-0.36479753255844116,
-0.12959592044353485,
-0.31839683651924133,
0.08293916285037994,
0.01462729461491108,
0.3101230263710022,
-0.07804861664772034,
-0.4465923011302948,
-0.14998690783977509,
-0.12719108164310455,
-0.30283883213996887,
-0.11380793154239655,
0.23568595945835114,
0.16787202656269073,
-0.6245532035827637,
-0.036053407937288284,
-0.03750605881214142,
0.10014309734106064,
0.09827149659395218,
-0.06636201590299606,
-0.059389397501945496,
0.1388954222202301,
0.3564494252204895,
0.13847024738788605,
-0.18375937640666962,
0.03978864476084709,
-0.3715117871761322,
-0.17577943205833435,
-0.05570264533162117,
0.19370725750923157,
-0.05041885003447533,
0.22364944219589233,
-1.0350896120071411,
0.5934346914291382,
0.3559403121471405,
0.28728246688842773,
0.43051522970199585,
-0.4176097810268402,
0.4025270640850067,
-0.220396488904953,
-0.5007924437522888,
0.2757895886898041,
-0.02934950217604637,
0.4587227404117584,
0.6782766580581665,
-0.7974653244018555,
0.059096768498420715,
0.42558473348617554,
-0.07840325683355331,
0.18456441164016724,
-0.17617468535900116,
0.011761127971112728,
0.09527817368507385,
-0.21374565362930298,
-0.29416775703430176,
-0.31200411915779114,
0.6108046174049377,
0.8301476240158081,
-0.3883852958679199,
-0.5398048758506775,
-0.2688247859477997,
0.7064244151115417,
0.7893635034561157,
-0.25929296016693115,
-0.7163683772087097,
-0.2946102023124695,
0.022442003712058067,
-0.045962702482938766,
0.11107758432626724,
-0.2901308536529541,
0.43129047751426697,
0.08144804835319519,
0.0743841677904129,
-0.20108801126480103,
-0.11378926038742065,
0.3154642581939697,
-0.3413502871990204,
-0.8456059694290161,
-0.41301560401916504,
0.0462779626250267,
-0.30891817808151245,
0.6632347106933594,
0.19351552426815033,
-0.08017503470182419,
-0.0381660982966423,
-0.20679809153079987,
0.05196825787425041,
-0.5568180084228516,
0.007605410646647215,
-0.3708336055278778,
0.6089888215065002,
0.15672741830348969,
0.2755133807659149,
-0.18767109513282776,
-0.2771015465259552,
-0.186101496219635,
-0.14403286576271057,
0.11216332763433456,
-0.32315966486930847,
0.07546527683734894,
0.26645126938819885,
-0.2642085552215576,
-0.3045026957988739,
0.300863653421402,
0.5276374816894531,
-1.2853273153305054,
-0.18755701184272766,
0.3888564705848694,
0.18738624453544617,
-0.1408873200416565,
0.5939938426017761,
0.1545541137456894,
-0.5761117935180664,
0.0874018520116806,
-0.2747448682785034,
0.019468802958726883,
0.08632127195596695,
0.8840279579162598,
0.08395247161388397,
0.2574802339076996,
-0.33069562911987305,
0.00749238021671772,
0.19390968978405,
0.233030766248703,
0.7420229315757751,
0.09081541001796722,
-0.39582371711730957,
0.21197578310966492,
0.06967758387327194,
0.26349273324012756,
-0.2934480309486389,
0.4633040726184845,
1.0279678106307983,
-0.8615356087684631,
-0.300241619348526,
-0.43726620078086853,
-0.17442502081394196,
0.10559691488742828,
-0.23052315413951874,
0.41562750935554504,
0.39717236161231995,
0.09719458967447281,
-0.16443243622779846,
-0.4995557367801666,
-0.3904358148574829,
-0.7520429491996765,
0.5719223618507385,
-0.0458911657333374,
0.25078457593917847,
0.09156981855630875,
0.7549178600311279,
0.4790624678134918,
-0.2912759482860565,
0.2247326821088791,
-0.4710370898246765,
-0.025363866239786148,
0.06601697951555252,
0.36744770407676697,
-0.3627467155456543,
-0.5345038175582886,
-0.2709185481071472,
-0.21952077746391296,
0.19994790852069855,
-0.20287251472473145,
0.22448505461215973,
-0.3096931278705597,
0.28287702798843384,
-0.4095304608345032,
-0.5108973979949951,
0.1932765394449234,
-0.375652551651001,
-0.7071293592453003,
-0.18701273202896118,
-0.29124099016189575,
0.24627932906150818,
0.134797602891922,
-0.3038111627101898,
-0.01979796215891838,
-0.8466936945915222,
0.5532692670822144,
0.5018520951271057,
-0.39346516132354736,
0.013170662336051464,
0.214821457862854,
0.18069757521152496,
0.6715743541717529,
-0.33560264110565186,
-0.4803276062011719,
0.3050205111503601,
-0.2931777834892273,
0.07110036164522171,
-0.3705670237541199,
-0.29746073484420776,
0.4451294541358948,
-0.3966967463493347,
-0.35267549753189087,
-0.01868666522204876,
0.3393767774105072,
0.4709230661392212,
1.0631417036056519,
0.22713284194469452,
0.02484726719558239,
0.2512178122997284,
0.5976750254631042,
-0.08122174441814423,
-0.5737953186035156,
0.156624436378479,
0.46565672755241394,
0.09797867387533188,
-0.7841476202011108,
-0.4661787748336792,
0.5856946706771851,
0.36549079418182373,
0.40568262338638306,
0.1210986003279686,
-0.5600086450576782,
-0.3681185245513916,
0.018464641645550728,
0.7107467651367188,
0.35790660977363586,
-0.08160397410392761,
-0.37684836983680725,
0.08130576461553574,
0.08795149624347687,
0.3514181673526764,
0.3247055411338806,
-0.004211656749248505,
0.18404188752174377,
0.2920798063278198,
-0.14683152735233307,
0.11838191002607346,
-0.06338617950677872,
-0.26657959818840027,
0.3240138590335846,
-0.06172926351428032,
-0.17933723330497742,
-0.619042694568634,
0.23986558616161346,
-0.34152472019195557,
0.040984779596328735,
0.3040027320384979,
0.6984111070632935,
-0.08734476566314697,
-0.09473811835050583,
-0.2111847698688507,
0.06088068708777428,
0.06390690058469772,
0.31423553824424744,
0.10619053989648819,
-0.5127999186515808,
-0.12240633368492126,
0.23287010192871094,
0.14622683823108673,
-0.2731882333755493,
-0.3132716417312622,
0.5969103574752808,
0.260686993598938,
0.6027488708496094,
-0.6835668087005615,
-0.5055163502693176,
-0.3362061381340027,
-0.1438724547624588,
-0.006957346573472023,
-0.5385420918464661,
-0.31907975673675537,
-0.071604423224926,
-0.3524147570133209,
-0.1310712695121765,
-0.05858083441853523,
-0.802932620048523,
-0.44217804074287415,
0.4183327555656433,
0.14600707590579987,
0.2360696941614151,
0.004787292331457138,
0.25809386372566223,
0.034624967724084854,
0.8807746171951294,
0.05301371216773987,
-0.13100294768810272,
-0.014830999076366425,
0.5559648871421814,
-0.8560217618942261,
0.46918419003486633,
-0.027816176414489746,
0.30529308319091797,
-0.9642494320869446,
-0.2590833306312561,
0.6657917499542236,
1.1556944847106934,
-0.29093360900878906,
-0.05904876068234444,
-0.06961411982774734,
0.22871097922325134,
0.3824816048145294,
-0.40101760625839233,
-0.02535758912563324,
-0.660818338394165,
-0.3668780028820038,
-0.7533875107765198,
0.2239222228527069,
0.07693470269441605,
0.11884669959545135,
-0.026701301336288452,
0.025465577840805054,
0.5931057929992676,
-0.6861656308174133,
0.27678003907203674,
0.38275036215782166,
-0.010193710215389729,
-0.20800991356372833,
0.41764307022094727,
-0.7566736340522766,
0.29053807258605957,
0.29364120960235596,
0.7330601811408997,
-0.4906269311904907,
-0.1589515209197998,
0.5137823224067688,
-0.3601807653903961,
-0.0735630914568901,
-0.47626373171806335,
-0.04310055077075958,
-0.046768732368946075,
0.30455282330513,
-0.24586333334445953,
-0.9000347256660461,
0.4651387631893158,
0.0025096775498241186,
-0.7811020016670227,
-0.07174792140722275,
-0.058361928910017014,
0.08591623604297638,
-0.4005283713340759,
-0.27009549736976624,
0.002166269812732935,
-0.11982391774654388,
-0.3591351807117462
] |
BACKGROUND: To describe the characteristics of patients with tuberculosis (TB) requiring intensive care and to identify the factors that predicts in-hospital mortality in a city of a developing country with intermediate-to-high TB endemicity. METHODS: We conducted a retrospective, cohort study, between November 2005 and November 2007. The patients with TB requiring intensive care were included. Predictors of mortality were assessed. The primary outcome was the in-hospital mortality. RESULTS: During the study period, 67 patients with TB required intensive care. Of them, 62 (92.5%) had acute respiratory failure and required mechanical ventilation. Forty-four (65.7%) patients died. Coinfection with human immunodeficiency virus was present in 46 (68.7%) patients. Early intensive care unit admission and ventilator-associated pneumonia were independently associated with the in-hospital mortality. CONCLUSIONS: In this study we found a high mortality rate in TB patients requiring intensive care, especially in those with an early ICU admission. | [
0.00598153006285429,
0.015518112108111382,
-0.014343606308102608,
0.026502929627895355,
0.00801500678062439,
0.007938144728541374,
0.007883251644670963,
0.011787425726652145,
-0.016447972506284714,
-0.02340780943632126,
0.0008672953117638826,
0.01429749559611082,
0.00043304753489792347,
0.023278389126062393,
-0.04605536162853241,
0.009215069934725761,
-0.012261336669325829,
0.04708515852689743,
0.006275750696659088,
-0.02026352286338806,
-0.019461780786514282,
-0.01303761638700962,
0.009553862735629082,
0.011697188019752502,
-0.008821848779916763,
0.0017233500257134438,
0.0016877350863069296,
0.00011199899017810822,
-0.0008609170326963067,
-0.0005874293856322765,
-0.01884104125201702,
0.027102099731564522,
0.014518721960484982,
0.02273758128285408,
0.01874566078186035,
-0.020528338849544525,
0.006487560458481312,
0.013539673760533333,
-0.04405350238084793,
-0.0036500864662230015,
0.014283432625234127,
-0.009684545919299126,
0.00205366313457489,
0.002500360133126378,
-0.005796067416667938,
0.020896675065159798,
-0.006928230635821819,
-0.005360885057598352,
0.002703464822843671,
0.0050487397238612175,
-0.002515392145141959,
0.0037613017484545708,
-0.00933448038995266,
0.010253239423036575,
-0.005774639546871185,
-0.007248915731906891,
0.020820073783397675,
0.008297856897115707,
-0.046103544533252716,
0.00927747692912817,
-0.012258676812052727,
-0.004792011808604002,
-0.008197193965315819,
-0.016098525375127792,
-0.012607429176568985,
-0.0671861469745636,
0.014609714038670063,
0.016899708658456802,
-0.007265558000653982,
0.0034253839403390884,
-0.016907406970858574,
0.009760353714227676,
0.007469248492270708,
0.004341808147728443,
-0.02264043316245079,
-0.004321286454796791,
-0.01792043074965477,
0.026374656707048416,
0.012330286204814911,
-0.006665278226137161,
0.005694213788956404,
0.011155128479003906,
-0.010386432521045208,
0.023917410522699356,
0.006211012601852417,
0.005968731828033924,
-0.0055039143189787865,
-0.011586550623178482,
0.010963719338178635,
0.008291485719382763,
0.01573646441102028,
-0.028259649872779846,
-0.025307144969701767,
-0.022572752088308334,
-0.025351349264383316,
-0.001847446896135807,
-0.0066813090816140175,
0.025088556110858917,
-0.01103983074426651,
-0.01686713472008705,
-0.01490863785147667,
-0.017696009948849678,
0.02212212234735489,
0.015862882137298584,
-0.011295398697257042,
0.009549340233206749,
0.004016031511127949,
0.02349034883081913,
0.026711085811257362,
0.004954156931489706,
0.000922807608731091,
0.014438155107200146,
0.002923430874943733,
-0.01214681752026081,
0.006846695207059383,
-0.03295990452170372,
0.017328258603811264,
-0.015638984739780426,
0.005172700621187687,
-0.010449775494635105,
0.0223197303712368,
0.004067530855536461,
-0.016399912536144257,
-0.006110597401857376,
0.0009189926786348224,
0.01859624683856964,
0.0006716130301356316,
-0.003414233447983861,
0.006854210514575243,
0.0036351869348436594,
-0.006207096390426159,
-0.012245568446815014,
0.011045673862099648,
0.01014618668705225,
-0.0020943849813193083,
-0.0005381254013627768,
-0.02439512312412262,
0.004117431119084358,
0.011329066008329391,
0.01982954889535904,
0.0007748727221041918,
0.015073582530021667,
-0.008974798955023289,
0.010897013358771801,
-0.013587932102382183,
0.007098987698554993,
-0.00019219005480408669,
0.003818769473582506,
0.002852658275514841,
-0.0042549846693873405,
0.005651985295116901,
-0.019052112475037575,
-0.007767878472805023,
-0.017232317477464676,
0.015672609210014343,
-0.011226397007703781,
0.002071373164653778,
-0.020623834803700447,
-0.00714385649189353,
-0.01879035495221615,
0.02213919162750244,
-0.012593499384820461,
-0.006880452390760183,
0.00808180496096611,
0.012836277484893799,
0.03454846888780594,
-0.0032033189199864864,
0.0010770686203613877,
0.021595746278762817,
-0.00015093706315383315,
-0.008640468120574951,
-0.004190734587609768,
-0.018732760101556778,
0.011873111128807068,
0.021072782576084137,
0.006672621704638004,
-0.000930112786591053,
0.008443580009043217,
-0.0012804584112018347,
0.06700444221496582,
0.02689518593251705,
-0.012770245783030987,
-0.00786663219332695,
-0.004690114874392748,
0.006477036979049444,
0.002967161126434803,
-0.0058425795286893845,
-0.00843162089586258,
0.003333640517666936,
0.012282855808734894,
0.017161600291728973,
-0.011629365384578705,
-0.015318091958761215,
-0.0161545742303133,
0.014242246747016907,
0.0030892910435795784,
0.001349790720269084,
-0.00505378982052207,
0.010401077568531036,
0.006225782446563244,
-0.010898075066506863,
0.0068467459641397,
0.02328936569392681,
0.02558078244328499,
-0.02308603748679161,
0.016610518097877502,
0.016550490632653236,
-0.018014542758464813,
0.002910180948674679,
0.007151119876652956,
0.017641939222812653,
-0.036576006561517715,
0.019670475274324417,
-0.006651953794062138,
-0.008281974121928215,
0.0020659861620515585,
0.009022640995681286,
0.016423678025603294,
-0.03907684609293938,
-0.01719759590923786,
-0.0008824878605082631,
0.010191046632826328,
-0.021590404212474823,
0.01284145750105381,
-0.008106203749775887,
-0.01834913343191147,
0.010232496075332165,
0.01011470053344965,
0.0018714680336415768,
-0.0035871979780495167,
-0.020231332629919052,
-0.0307515487074852,
-0.007352566812187433,
-0.015347456559538841,
0.009533821605145931,
0.022383015602827072,
0.012269452214241028,
0.006536081433296204,
0.006587429437786341,
-0.018192196264863014,
-0.00156305986456573,
-0.007196344435214996,
0.02909133955836296,
0.027542440220713615,
0.0016194272320717573,
-0.015342311933636665,
0.027562662959098816,
0.012825369834899902,
-0.0017254031263291836,
0.002667417284101248,
0.004543308634310961,
-0.021145548671483994,
0.014466347172856331,
0.01987433433532715,
0.006044508423656225,
-0.0025786161422729492,
0.009145159274339676,
0.008750655688345432,
0.023295721039175987,
-0.005635173991322517,
0.021303795278072357,
0.003914218861609697,
0.008004187606275082,
0.0010992633178830147,
0.004473425447940826,
-0.014572152867913246,
0.004966199863702059,
0.002566214185208082,
0.0392601378262043,
0.006937216967344284,
0.007383414544165134,
-0.00937841460108757,
0.00022489053662866354,
-0.08121398091316223,
-0.007227771915495396,
-0.014551350846886635,
-0.00896533951163292,
0.012924093753099442,
0.005006828811019659,
0.024269189685583115,
0.00334920734167099,
-0.0024273814633488655,
0.01892201229929924,
-0.003719338681548834,
0.012673763558268547,
-0.006834434345364571,
-0.000054067932069301605,
-0.012515108101069927,
0.0016270490596070886,
0.001899374183267355,
-0.004934896714985371,
-0.010793941095471382,
-0.007662571035325527,
0.01793098635971546,
-0.008624913170933723,
0.04147325083613396,
-0.024078067392110825,
0.021299684420228004,
0.024288326501846313,
0.02548099495470524,
-0.0022936826571822166,
0.010336840525269508,
0.0030631893314421177,
0.02847306989133358,
0.015371579676866531,
0.004275399725884199,
-0.017361143603920937,
-0.008467374369502068,
-0.0045262547209858894,
0.012018388137221336,
-0.0130392387509346,
-0.020462146028876305,
0.010749002918601036,
0.009528007358312607,
0.008953917771577835,
-0.011969493702054024,
-0.003500730264931917,
0.0050915745086967945,
0.0026599185075610876,
-0.006678044330328703,
0.003718624822795391,
0.011132340878248215,
0.0062143574468791485,
-0.03140696510672569,
-0.009903528727591038,
0.026806550100445747,
0.014347504824399948,
-0.005795500241219997,
-0.018054062500596046,
-0.018137890845537186,
-0.028273914009332657,
-0.005371947772800922,
-0.015776703134179115,
-0.00823686458170414,
0.005184948910027742,
0.007557612378150225,
-0.01896192505955696,
0.0015178229659795761,
-0.001287894556298852,
0.013307888060808182,
-0.007269104477018118,
-0.007067948114126921,
-0.014774185605347157,
0.015064973384141922,
0.011546364054083824,
-0.007383869495242834,
-0.013332447968423367,
0.020320963114500046,
-0.0014836093178018928,
-0.01592567004263401,
-0.013232473284006119,
0.010969450697302818,
-0.0023590330965816975,
0.0011781002394855022,
0.002316136844456196,
0.003375607542693615,
0.011763383634388447,
-0.0007913017179816961,
-0.04016382619738579,
0.01717887446284294,
0.04399680346250534,
0.012731192633509636,
-0.015201080590486526,
0.007119627669453621,
0.0243295319378376,
-0.028103241696953773,
0.011216606944799423,
0.011368127539753914,
-0.021974600851535797,
-0.006044205278158188,
-0.0051897382363677025,
0.008877381682395935,
0.008756596595048904,
-0.018854279071092606,
-0.004862985573709011,
0.0013021507766097784,
-0.011205901391804218,
-0.008751243352890015,
0.012528626248240471,
0.013818666338920593,
-0.012159795500338078,
-0.008108053356409073,
-0.013648947700858116,
-0.01012298185378313,
0.006362296640872955,
-0.004095151089131832,
0.03325759246945381,
0.014360126107931137,
0.024004090577363968,
-0.0012217331677675247,
-0.021975582465529442,
0.07244668900966644,
-0.006751349661499262,
0.017483528703451157,
-0.008209412917494774,
-0.007798751816153526,
-0.018301963806152344,
0.004079691134393215,
-0.004936096258461475,
0.03792354464530945,
-0.020564038306474686,
0.01110062189400196,
0.019089065492153168,
-0.008718065917491913,
-0.018231209367513657,
-0.005160468630492687,
0.001336394459940493,
-0.007418298628181219,
0.006613744888454676,
-0.008316715247929096,
-0.009523658081889153,
0.007608029060065746,
-0.022567857056856155,
-0.017067603766918182,
-0.0023317309096455574,
0.002074341755360365,
-0.015032364055514336,
-0.023173384368419647,
-0.014254782348871231,
-0.01693057268857956,
0.0037639555521309376,
0.007330846972763538,
0.024714866653084755,
-0.005342348478734493,
-0.013077862560749054,
0.015553846955299377,
0.01398794911801815,
0.004351169802248478,
0.010001140646636486,
0.0021304988767951727,
-0.01722203940153122,
0.017362236976623535,
-0.004863203037530184,
-0.006754244212061167,
0.012243438512086868,
0.013515057042241096,
0.006794405169785023,
-0.006617425940930843,
-0.0031347160693258047,
-0.015364626422524452,
0.033200670033693314,
-0.004529625177383423,
0.005755415186285973,
0.012843511067330837,
0.019156374037265778,
-0.001348182326182723,
-0.014490215107798576,
-0.006199472583830357,
-0.008739093318581581,
-0.0036395255010575056,
0.0026653953827917576,
0.0067806001752614975,
-0.04758623614907265,
-0.006912184413522482,
-0.006955204531550407,
0.00375147326849401,
-0.0183124877512455,
0.0011609348002821207,
-0.0003709332086145878,
-0.004257973283529282,
0.0010236876551061869,
0.004581552930176258,
-0.012587141245603561,
-0.00821431539952755,
-0.006193396169692278,
-0.011231416836380959,
0.022066272795200348,
-0.008945666253566742,
-0.01032864861190319,
-0.0017217155545949936,
-0.017897916957736015,
-0.01863895170390606,
0.03146081417798996,
0.03803759440779686,
-0.01875299960374832,
0.024333925917744637,
0.006431886926293373,
-0.032557692378759384,
-0.07445290684700012,
-0.01731318235397339,
0.0004869669210165739,
-0.011235583573579788,
-0.017494816333055496,
0.018678788095712662,
-0.008747829124331474,
0.014338582754135132,
-0.016614079475402832,
-0.012392446398735046,
0.013482258655130863,
-0.004469428211450577,
-0.023761406540870667,
-0.007146860472857952,
0.014655537903308868,
0.02094442769885063,
-0.017040517181158066,
-0.011420255526900291,
-0.009094953536987305,
0.011260592378675938,
0.007029284723103046,
0.04354241490364075,
-0.03623422235250473,
-0.01813558116555214,
0.01046931091696024,
-0.08133219927549362,
0.006585986819118261,
-0.0099383145570755,
-0.005116784013807774,
0.0019214858766645193,
-0.019534150138497353,
0.005808682180941105,
-0.0013987328857183456,
-0.018666181713342667,
-0.01845487765967846,
-0.014050847850739956,
0.00018538301810622215,
0.016259171068668365,
-0.007118674460798502,
0.01677466370165348,
-0.0024104476906359196,
0.015597982332110405,
-0.002458927221596241,
-0.022811535745859146,
-0.0033467747271060944,
0.004150527063757181,
0.022304914891719818,
-0.0044583831913769245,
-0.005521861836314201,
-0.009264349937438965,
-0.01865818351507187,
-0.012735152617096901,
0.010428526438772678,
0.01970759965479374,
-0.01572870835661888,
0.0016758034471422434,
-0.000547570176422596,
-0.0016712641809135675,
0.00611930713057518,
0.029183808714151382,
0.0006405229214578867,
0.013236412778496742,
-0.01012469083070755,
0.03862098231911659,
0.0024572217371314764,
0.00018000323325395584,
0.0005681696347892284,
0.014742478728294373,
0.006513303145766258,
0.0033217305317521095,
-0.006031622178852558,
0.007240953389555216,
-0.004848603159189224,
0.008800230920314789,
0.011711467988789082,
0.001997374463826418,
-0.00986383855342865,
-0.003727968316525221,
0.006292769219726324,
-0.030025413259863853,
-0.00929851084947586,
-0.010473647154867649,
-0.015811162069439888,
0.0008342615328729153,
0.017997324466705322,
0.0006294562481343746,
-0.00944035779684782,
-0.021853601559996605,
0.07220131158828735,
-0.011410713195800781,
0.012690868228673935,
-0.026290200650691986,
-0.014809589833021164,
-0.0009691426530480385,
-0.033665191382169724,
-0.0004833308048546314,
-0.0032014488242566586,
-0.014651288278400898,
0.02905082516372204,
-0.006455317139625549,
0.013468950055539608,
0.004864121787250042,
0.01874428242444992,
-0.006701923441141844,
-0.003877287730574608,
-0.005413280799984932,
-0.032197777181863785,
-0.012908032163977623,
-0.003009724896401167,
0.02861502207815647,
-0.03683283179998398,
0.004164515528827906,
0.00656441505998373,
-0.007455134764313698,
0.025245822966098785,
0.009036052040755749,
0.00573838921263814,
0.0004207976162433624,
-0.0083523103967309,
0.03508097305893898,
0.006502997595816851,
-0.005195572040975094,
0.013060224242508411,
-0.00836285948753357,
-0.019208211451768875,
0.003532781731337309,
-0.009270147420465946,
0.021142609417438507,
-0.005594212096184492,
0.0011486546136438847,
0.0078811664134264,
-0.017106574028730392,
0.022404775023460388,
-0.0005084974691271782,
0.0028986409306526184,
-0.021472761407494545,
-0.019305456429719925,
0.020925015211105347,
0.0030010449700057507,
0.012674454599618912,
-0.0011778648477047682,
-0.008383617736399174,
-0.009313471615314484,
-0.015082377009093761,
-0.0029234245885163546,
0.022293049842119217,
0.023169871419668198,
-0.009550817310810089,
-0.009933112189173698,
-0.004076865501701832,
0.008203632198274136,
-0.0217999666929245,
0.011677836067974567,
-0.012276852503418922,
0.01500670611858368,
-0.01468239352107048,
0.00012704310938715935,
0.013075549155473709,
0.017256027087569237,
0.005877109244465828,
0.004140770994126797,
-0.011030500754714012,
0.015778202563524246,
0.001832838635891676,
0.0030584295745939016,
0.02779582142829895,
0.010368980467319489,
0.004470571875572205,
-0.015303857624530792,
-0.014229300431907177,
-0.007263094652444124,
-0.0030321641825139523,
-0.03200671821832657,
-0.015034981071949005,
0.021925125271081924,
0.0037840595468878746,
-0.014431517571210861,
0.0021452312357723713,
-0.00932363048195839,
0.011048611253499985,
-0.007289199158549309,
-0.002030147472396493,
0.008097088895738125,
0.033990561962127686,
0.01644022949039936,
-0.0006908004870638251,
0.020224805921316147,
-0.0139570077881217,
0.001359762391075492,
0.01173577830195427,
-0.004431967623531818,
-0.03156868368387222,
-0.013283271342515945,
-0.0037904155906289816,
-0.013731861487030983,
0.023579280823469162,
0.013327380642294884,
0.017337949946522713,
-0.014288542792201042,
-0.019381698220968246,
0.0032281498424708843,
-0.003850035835057497,
-0.00530792772769928,
-0.007938306778669357,
0.0015024226158857346,
-0.00852431170642376,
0.012525132857263088,
-0.010759925469756126,
-0.014371257275342941,
0.0016491215210407972,
-0.02435876429080963,
0.02464883215725422,
0.015543918125331402,
0.005367721430957317,
-0.0037548637483268976,
0.0005947789177298546,
0.006301699206233025,
0.029337096959352493,
0.004378506913781166,
-0.007808104623109102,
0.0003447373164817691,
0.007726144976913929,
-0.0042297448962926865,
0.029349345713853836,
0.007657219655811787,
0.02041628770530224,
0.0022055278532207012,
-0.005531792528927326,
-0.012936937622725964,
-0.014787491410970688,
-0.0007635387592017651,
-0.005535959731787443,
0.011913591995835304,
0.006681178696453571,
-0.00031663815025240183,
0.015496911481022835,
0.0175798200070858,
-0.0002935450756922364,
-0.00962788239121437,
0.0020562498830258846,
-0.011008648201823235,
-0.004070591181516647,
0.0008168030763044953,
0.004773425403982401,
0.010485832579433918,
0.012163238599896431,
-0.023588739335536957,
0.006156920455396175,
-0.010003176517784595,
-0.017585186287760735,
-0.008739269338548183,
0.005487739574164152,
-0.006724497769027948,
0.004054861608892679,
-0.00018310453742742538,
-0.00623565586283803,
-0.012040567584335804,
0.006240252871066332,
-0.0264205913990736,
0.006143791135400534,
0.012872983701527119,
0.0166175439953804,
-0.02877742052078247,
-0.0031149513088166714,
-0.00013422511983662844,
-0.004015039652585983,
0.0067460797727108,
0.021673837676644325,
0.003514315700158477,
0.004172785207629204,
-0.007593364454805851,
-0.013367725536227226,
-0.004166239872574806,
0.004279973916709423,
-0.014681708067655563,
-0.005163419060409069,
0.007184671238064766,
-0.012871937826275826,
-0.031241945922374725,
-0.009621096774935722,
-0.022051233798265457,
-0.006540295667946339,
0.018132075667381287,
0.020034028217196465,
-0.010311661288142204,
-0.01434926688671112,
-0.0024018764961510897,
-0.011944524012506008,
-0.006227449979633093,
-0.022231264039874077
] | [
0.5101259350776672,
-0.09760326147079468,
-0.4774119555950165,
0.042808499187231064,
0.16222254931926727,
1.0045268535614014,
0.5046346783638,
-0.01211793813854456,
-0.14167582988739014,
-0.37715598940849304,
0.09031254053115845,
0.6310970783233643,
-0.060977015644311905,
0.03242730721831322,
-0.15270505845546722,
0.7844863533973694,
0.7679383754730225,
0.11259859055280685,
-0.09024359285831451,
-0.2910766899585724,
-0.17441131174564362,
-0.3597530126571655,
0.4173668920993805,
0.3636758625507355,
-0.2527170777320862,
0.011811347678303719,
0.5154234170913696,
0.361614853143692,
0.0504257008433342,
-0.07923651486635208,
0.038777999579906464,
0.39971503615379333,
0.08746492862701416,
-0.17426460981369019,
0.26740768551826477,
-0.030122041702270508,
0.36981725692749023,
0.04506949335336685,
0.1252901405096054,
-0.6528090834617615,
-0.09153177589178085,
0.10404690355062485,
0.11560787260532379,
0.4750058650970459,
-0.042261525988578796,
-0.4885779321193695,
-1.0867558717727661,
0.5191927552223206,
-0.2602391541004181,
0.03346409276127815,
0.5653653740882874,
0.46196380257606506,
0.5077335238456726,
0.38824179768562317,
-0.19844070076942444,
0.118250772356987,
-0.209263876080513,
0.0024187800008803606,
0.08173275738954544,
-0.3503439426422119,
0.1876557171344757,
-0.06296400725841522,
0.28810781240463257,
0.32329297065734863,
-0.14566272497177124,
0.4951540231704712,
-0.03298013657331467,
0.14622633159160614,
0.2930051386356354,
-0.13216501474380493,
-0.04524797201156616,
-0.30447447299957275,
-0.13604196906089783,
-0.030162973329424858,
-0.3707890808582306,
0.07848913222551346,
-0.1571768969297409,
-0.4001385569572449,
0.36285606026649475,
-0.08910869061946869,
0.139058917760849,
-0.45957696437835693,
0.1189129501581192,
-0.44585174322128296,
0.5209844708442688,
0.24607975780963898,
0.0276152566075325,
0.30268242955207825,
-0.07404783368110657,
-0.16712670028209686,
-0.31562042236328125,
-0.3060764670372009,
0.3396373987197876,
0.8036720752716064,
-0.24798521399497986,
0.4298558235168457,
0.13704447448253632,
-0.07096660137176514,
0.30247852206230164,
-0.23318231105804443,
-0.31970512866973877,
-0.14603348076343536,
0.159346342086792,
0.17991018295288086,
-0.6882304549217224,
-0.26693910360336304,
0.09986326098442078,
-0.19832873344421387,
-0.8222071528434753,
0.4199450612068176,
-0.4153479337692261,
-0.14341962337493896,
-0.1255791038274765,
-0.3328912556171417,
-0.21755270659923553,
0.1715763956308365,
0.09784705191850662,
-0.4005303382873535,
-0.15475301444530487,
0.10005154460668564,
-0.3919525742530823,
0.18694984912872314,
-0.3925107419490814,
0.18713268637657166,
-0.3238344192504883,
0.15945479273796082,
0.7479902505874634,
0.14995324611663818,
0.07187666743993759,
0.4129257798194885,
0.13383248448371887,
0.6639650464057922,
-0.3283318281173706,
0.09383518248796463,
-0.03952345997095108,
-0.5148953199386597,
0.21469201147556305,
0.30827271938323975,
-0.1006205826997757,
-0.03453248739242554,
-0.34246399998664856,
-0.24170053005218506,
-0.4445480704307556,
0.09850088506937027,
0.176930233836174,
-0.8132911324501038,
0.23941899836063385,
0.1006852388381958,
-0.04519076645374298,
-0.30982229113578796,
0.045009300112724304,
0.053426481783390045,
-0.4277139902114868,
-0.5309360027313232,
-0.08356000483036041,
0.3346322178840637,
-0.22973380982875824,
-0.27268165349960327,
-0.2702436149120331,
-0.13910850882530212,
0.4450434148311615,
0.5637350082397461,
0.031365592032670975,
0.04499155282974243,
0.5722681879997253,
-0.148077130317688,
-0.28533533215522766,
0.0764160305261612,
0.10010163486003876,
0.6278731226921082,
-0.287614643573761,
-0.30395856499671936,
-0.5116559863090515,
-0.44794586300849915,
-0.5049248933792114,
0.14569024741649628,
0.7765284776687622,
0.19415415823459625,
0.1213156059384346,
-0.28728264570236206,
-0.4504125714302063,
0.020282158628106117,
0.22828185558319092,
-0.4567215144634247,
0.4839068055152893,
-0.2826482355594635,
0.43741193413734436,
0.25723206996917725,
0.11195054650306702,
-0.13626261055469513,
-0.18128973245620728,
-0.5508469343185425,
0.6087166666984558,
-0.8423535823822021,
1.165520191192627,
-0.4748716950416565,
0.06500092148780823,
0.8107358813285828,
-0.015305689536035061,
-0.22212950885295868,
0.253301739692688,
0.23066473007202148,
0.6424513459205627,
-0.1920686662197113,
-0.5642885565757751,
-0.006025416310876608,
0.20973347127437592,
-0.31455567479133606,
-0.4148482084274292,
-0.08886843919754028,
0.4375484883785248,
-0.4495016634464264,
-0.4557836055755615,
-0.1577405482530594,
0.1754915416240692,
-0.1461305171251297,
-0.05841389298439026,
0.27851229906082153,
0.417561799287796,
-0.19589018821716309,
0.6222654581069946,
-0.7903124690055847,
0.271293580532074,
0.23498080670833588,
0.17360559105873108,
0.4229780435562134,
0.5010809302330017,
-0.04411358758807182,
0.7687057852745056,
-0.3770247995853424,
0.2000928670167923,
0.25156018137931824,
0.2230188250541687,
-0.6810293197631836,
-0.39395156502723694,
0.3627423346042633,
-0.24692313373088837,
-0.1267656534910202,
0.1436479240655899,
0.10123886913061142,
0.1233171820640564,
0.23889684677124023,
-0.641371488571167,
-0.04275796562433243,
0.07669877260923386,
-0.45263412594795227,
-0.5844424962997437,
0.10051674395799637,
-0.7017087340354919,
0.03437971696257591,
0.20040175318717957,
-0.07251330465078354,
0.18054655194282532,
-0.3145734667778015,
0.20238324999809265,
0.11363097280263901,
0.00772290350869298,
-0.6884433627128601,
0.16401639580726624,
-0.5098341107368469,
0.11316985636949539,
0.2795109748840332,
0.3797264099121094,
-0.04209216684103012,
0.3945331275463104,
-0.19537492096424103,
-0.6174235939979553,
-0.8111897110939026,
0.6691471934318542,
0.3208489716053009,
0.35786575078964233,
0.35800832509994507,
-0.42920151352882385,
0.24683159589767456,
0.05808485299348831,
-0.36010289192199707,
0.010751339606940746,
1.0110868215560913,
-0.6952005624771118,
-0.3365277945995331,
-0.04427025094628334,
0.11523853987455368,
0.6215694546699524,
-0.2237398773431778,
0.0217809546738863,
-0.09670037031173706,
-0.052165962755680084,
-0.03948846086859703,
-0.30267199873924255,
0.05354415625333786,
-0.1653878092765808,
0.4771108329296112,
-0.3927614986896515,
-0.44591736793518066,
0.15185709297657013,
0.33804428577423096,
-0.32648926973342896,
0.510737419128418,
0.6622897386550903,
-0.27396291494369507,
0.1616079956293106,
0.1828129142522812,
0.0023476555943489075,
-0.12292692065238953,
-0.16934165358543396,
-0.08135013282299042,
-0.447610467672348,
-0.031148582696914673,
-6.073204040527344,
0.35947245359420776,
-0.19937829673290253,
-0.23479565978050232,
-0.30110934376716614,
0.1070316806435585,
0.7069877982139587,
0.12955473363399506,
0.3609694242477417,
-0.16378231346607208,
0.20351888239383698,
0.456878125667572,
0.07610973715782166,
0.2794124484062195,
0.15945439040660858,
0.2236999124288559,
0.11687321960926056,
-0.2569490373134613,
0.175740048289299,
0.08543891459703445,
0.36206161975860596,
-0.3999093174934387,
-0.07481912523508072,
0.006267670076340437,
0.5110321044921875,
0.6030978560447693,
-1.0437920093536377,
0.507274329662323,
-0.07846072316169739,
-0.028987955302000046,
0.25722894072532654,
-0.7031583786010742,
-0.2137596756219864,
-0.06073957309126854,
0.32073983550071716,
0.08793182671070099,
0.2356758713722229,
0.011218243278563023,
0.11486687511205673,
-0.4624616503715515,
-0.061916373670101166,
0.5738556385040283,
-0.37710896134376526,
-0.3098406195640564,
0.03448169678449631,
-0.22378601133823395,
0.21196196973323822,
0.20821240544319153,
0.01606464758515358,
0.8012637495994568,
0.04274941608309746,
0.05010823905467987,
-0.19332614541053772,
0.6952425837516785,
0.05092264339327812,
-0.23097901046276093,
-0.3569290041923523,
0.4516249895095825,
-0.04141159728169441,
0.4220377206802368,
-0.26149046421051025,
-0.016054322943091393,
0.07497826963663101,
-0.8336014151573181,
0.10360610485076904,
0.1733209788799286,
-0.774219274520874,
-0.2845194935798645,
-0.2687154710292816,
0.3619251251220703,
-0.14615370333194733,
-0.04053356498479843,
0.3015613555908203,
-0.5489187836647034,
0.04519244283437729,
-0.4507141709327698,
0.06350168585777283,
0.037682149559259415,
0.04905744269490242,
-0.5143857598304749,
0.041077785193920135,
-0.2683783173561096,
0.6647295355796814,
0.1158001720905304,
0.10941405594348907,
0.18921521306037903,
-0.22159412503242493,
0.08250457048416138,
-0.3617081046104431,
-0.12634983658790588,
0.6172564029693604,
-0.5517013072967529,
0.06065892055630684,
0.15885405242443085,
0.1575159728527069,
0.7022587060928345,
0.37877267599105835,
-0.26489001512527466,
0.32718032598495483,
-0.19524893164634705,
0.8153102993965149,
-0.11628033965826035,
-0.3829522132873535,
-0.5855567455291748,
-0.13259904086589813,
-0.313814252614975,
-0.9937283992767334,
0.06352896988391876,
0.8247676491737366,
-0.6265677213668823,
0.06060605123639107,
0.15155433118343353,
-0.28133273124694824,
-0.340360552072525,
0.694965124130249,
-0.25880977511405945,
-0.071181520819664,
-0.342695415019989,
0.517539918422699,
0.12068521976470947,
0.3962058424949646,
0.10768049955368042,
0.03423355147242546,
0.62418133020401,
0.11561034619808197,
-0.130778968334198,
0.2909034490585327,
0.5294030904769897,
-0.7378836274147034,
-0.11875848472118378,
-0.21493294835090637,
0.3368731439113617,
-0.3688529431819916,
-0.11965436488389969,
0.17891108989715576,
-0.10621216893196106,
-0.5539327263832092,
0.010465477593243122,
0.3018798828125,
0.29854559898376465,
-0.13262483477592468,
0.05917859077453613,
-0.4703224301338196,
0.08799891918897629,
0.3967415690422058,
-0.27153337001800537,
-0.09816453605890274,
-0.3027619421482086,
-0.09178727865219116,
-0.06086776778101921,
0.25334078073501587,
0.038613203912973404,
0.3025769889354706,
0.043767910450696945,
-0.5223982930183411,
-0.058297473937273026,
0.3698600232601166,
0.012503666803240776,
-0.0728570744395256,
-0.5364721417427063,
0.6587755084037781,
0.1473478525876999,
-1.277038335800171,
-0.011214827187359333,
0.24972596764564514,
-0.6349583864212036,
0.16880744695663452,
-0.42922598123550415,
0.2382756471633911,
0.151213601231575,
0.30401188135147095,
-0.6855427622795105,
0.2753582298755646,
-0.08671057969331741,
0.18060405552387238,
-0.2780817151069641,
-0.5245596170425415,
0.14845499396324158,
-0.061594050377607346,
0.3517925441265106,
0.5147373080253601,
-0.3347441554069519,
-0.506745457649231,
0.24683915078639984,
1.0749824047088623,
0.8636137247085571,
-0.15133504569530487,
-0.5047364234924316,
-0.028682468459010124,
-0.1453881710767746,
0.3093923032283783,
-0.3669075667858124,
0.7928564548492432,
-0.025428788736462593,
-0.011012266390025616,
-0.5219776034355164,
-0.05194083973765373,
0.09374029189348221,
-0.08979504555463791,
-0.11867430806159973,
-0.1386687308549881,
0.44360819458961487,
-0.4146694242954254,
0.36583182215690613,
0.43704932928085327,
-0.1829153597354889,
0.031468603760004044,
-0.24584025144577026,
-0.047945428639650345,
-0.39323902130126953,
-0.3186073899269104,
-0.19567987322807312,
-0.29651498794555664,
0.4869348406791687,
-0.8389527797698975,
0.3453148603439331,
0.06758973002433777,
-0.5793147087097168,
-0.12784749269485474,
0.1844453066587448,
0.160650372505188,
-0.08105599135160446,
-0.358585923910141,
-0.2641390562057495,
-0.10428039729595184,
0.19915832579135895,
0.7723874449729919,
-0.8323526978492737,
-0.5687188506126404,
0.11328618973493576,
-0.929241418838501,
0.007113480009138584,
0.10276608169078827,
-0.4317849278450012,
-0.7594221234321594,
0.09235374629497528,
0.17571625113487244,
-0.22344282269477844,
0.04221672937273979,
0.13252951204776764,
-0.05554131790995598,
0.7772440314292908,
0.18360619246959686,
-0.3777840733528137,
0.1261889934539795,
-0.020647767931222916,
0.1430361121892929,
-0.5393610596656799,
-0.21318309009075165,
0.02692694030702114,
-0.02769654616713524,
-0.42400333285331726,
-0.11805575340986252,
-0.6093230843544006,
0.0069335163570940495,
0.08711617439985275,
-0.03749682754278183,
-0.1702028512954712,
0.138076052069664,
0.3363938331604004,
-0.11209804564714432,
-0.6515727043151855,
0.0594031997025013,
-0.3260802626609802,
0.0034793936647474766,
-0.06409446895122528,
-0.04016432911157608,
-0.09592772275209427,
0.08350130915641785,
-0.6789705753326416,
0.4042799174785614,
0.031982529908418655,
0.6142251491546631,
0.1715644747018814,
0.13119524717330933,
0.1791708767414093,
-0.5365921854972839,
0.29517653584480286,
-0.23804917931556702,
0.27899476885795593,
-0.5592545866966248,
-0.7016285061836243,
0.04577827453613281,
-0.001993205165490508,
0.07113128155469894,
-0.5664765238761902,
0.07481750100851059,
-0.008985670283436775,
-0.3895873725414276,
-0.5211942791938782,
0.08150462806224823,
-0.3892219066619873,
-0.5082764029502869,
-0.10274703800678253,
0.037781622260808945,
-0.00023732571571599692,
0.22085823118686676,
0.8619660139083862,
0.3845437169075012,
-0.3411881923675537,
-0.232495978474617,
0.93137127161026,
0.5099202394485474,
-0.5645387768745422,
0.506222665309906,
0.07381116598844528,
0.45203661918640137,
0.03653785586357117,
-0.04442374035716057,
-0.055793892592191696,
0.5855178236961365,
0.13026507198810577,
0.3188941180706024,
0.6029347777366638,
-0.68144690990448,
-0.2979606091976166,
-0.6463185548782349,
-0.5024160146713257,
0.4539150595664978,
0.07806921750307083,
0.04987027868628502,
0.8080617785453796,
0.6002090573310852,
0.11670790612697601,
-0.3438340425491333,
0.7865012884140015,
-0.36205190420150757,
0.2908500134944916,
0.13087083399295807,
0.1298062801361084,
0.5009371042251587,
0.9138860702514648,
-0.22109182178974152,
0.042455073446035385,
-0.19677311182022095,
0.6803185939788818,
0.36778026819229126,
-0.6088560223579407,
-0.28775283694267273,
-0.14116428792476654,
0.613168478012085,
0.07913282513618469,
0.17016008496284485,
-0.21238647401332855,
0.015403533354401588,
0.5464762449264526,
-0.05118293687701225,
0.025408782064914703,
0.1835818737745285,
0.2702503204345703,
0.21254044771194458,
-0.1718815714120865,
-0.2661861479282379,
0.4666828513145447,
-0.28909143805503845,
0.28417515754699707,
0.09770633280277252,
-0.04181892052292824,
-0.5692331194877625,
0.36856111884117126,
0.32058951258659363,
0.21878135204315186,
0.003796759992837906,
0.02635212242603302,
-0.28485777974128723,
0.11814983934164047,
0.5650599002838135,
-0.026896977797150612,
0.08055667579174042,
-0.24565055966377258,
-0.05436265841126442,
0.01686100661754608,
-0.36876022815704346,
0.31157055497169495,
0.34687045216560364,
-0.33405405282974243,
0.038896605372428894,
0.23417189717292786,
0.03807104378938675,
0.46188685297966003,
-0.29929623007774353,
0.011182621121406555,
-0.14409121870994568,
-0.13380728662014008,
-0.3499751091003418,
-0.14200401306152344,
-0.35298991203308105,
0.08610685914754868,
0.38679423928260803,
-0.027710488066077232,
-0.004509521648287773,
-0.3950883448123932,
0.36525559425354004,
0.01684611849486828,
0.03848562389612198,
-0.4183776080608368,
-0.251161128282547,
0.5117592215538025,
0.21345308423042297,
0.36726129055023193,
-0.0933714434504509,
-0.0051038917154073715,
-0.22461676597595215,
0.6610708236694336,
0.04206390678882599,
0.3444335460662842,
-0.20742899179458618,
0.11634693294763565,
-0.7326608896255493,
-0.12761276960372925,
0.2927549481391907,
0.15584233403205872,
-0.22892816364765167,
-0.021589741110801697,
-0.12392596155405045,
0.47203487157821655,
0.3655222952365875,
-0.21351012587547302,
-0.4844095706939697,
-0.4179198443889618,
-0.37810906767845154,
-0.9348544478416443,
0.2954126298427582,
-0.1587497442960739,
-0.19900277256965637,
-0.3912351131439209,
0.24042272567749023,
0.5458127856254578,
-0.027247726917266846,
0.6376035213470459,
-0.28906893730163574,
-0.15445543825626373,
-0.4725760221481323,
0.19587692618370056,
-0.6928538680076599,
0.2966197431087494,
0.4406885802745819,
0.03916490450501442,
0.16860461235046387,
-0.12355035543441772,
-0.042059026658535004,
-0.5411078929901123,
0.12545813620090485,
0.3274737298488617,
-0.08221563696861267,
0.31272998452186584,
0.1554022580385208,
-0.031476303935050964,
-0.610326886177063,
0.4096769690513611,
-0.3198125660419464,
-0.4275668263435364,
0.018312351778149605,
-0.06779634952545166,
-0.3676797151565552,
-0.2308027595281601,
0.07193166017532349,
-0.7761310935020447,
-0.1549336463212967,
-0.22223657369613647
] |
Efforts to develop a broadly protective vaccine against the highly pathogenic avian influenza A (HPAI) H5N1 virus have focused on highly conserved influenza gene products. The viral nucleoprotein (NP) and ion channel matrix protein (M2) are highly conserved among different strains and various influenza A subtypes. Here, we investigate the relative efficacy of NP and M2 compared to HA in protecting against HPAI H5N1 virus. In mice, previous studies have shown that vaccination with NP and M2 in recombinant DNA and/or adenovirus vectors or with adjuvants confers protection against lethal challenge in the absence of HA. However, we find that the protective efficacy of NP and M2 diminishes as the virulence and dose of the challenge virus are increased. To explore this question in a model relevant to human disease, ferrets were immunized with DNA/rAd5 vaccines encoding NP, M2, HA, NP+M2 or HA+NP+M2. Only HA or HA+NP+M2 vaccination conferred protection against a stringent virus challenge. Therefore, while gene-based vaccination with NP and M2 may provide moderate levels of protection against low challenge doses, it is insufficient to confer protective immunity against high challenge doses of H5N1 in ferrets. These immunogens may require combinatorial vaccination with HA, which confers protection even against very high doses of lethal viral challenge. | [
-0.0025823190808296204,
0.02029847353696823,
-0.012180997058749199,
0.02719048596918583,
0.0074505191296339035,
-0.0123079102486372,
0.012293117120862007,
-0.0034273099154233932,
-0.015534168109297752,
-0.02686772495508194,
-0.008641840890049934,
0.014951199293136597,
-0.023430217057466507,
0.0062494175508618355,
0.00669691851362586,
-0.0022532548755407333,
-0.013864628970623016,
0.012564435601234436,
0.008220208808779716,
0.015196899883449078,
-0.005444285459816456,
0.03121011145412922,
0.012221476063132286,
-0.02804647572338581,
0.0002629542723298073,
0.029298443347215652,
0.0022730545606464148,
-0.010479546152055264,
0.009874298237264156,
0.0014365999959409237,
0.053897708654403687,
-0.025449629873037338,
0.03480106592178345,
0.0014854222536087036,
-0.006239447742700577,
0.0318327359855175,
-0.0019706604070961475,
0.036414168775081635,
0.010483115911483765,
-0.005065761506557465,
0.009113188832998276,
-0.014724494889378548,
0.004405567888170481,
-0.03682684898376465,
-0.006058867089450359,
0.03310350328683853,
-0.0031404600013047457,
0.007517052814364433,
0.009725060313940048,
0.008747443556785583,
0.0015250511933118105,
-0.00002313358709216118,
-0.021840021014213562,
0.004914752673357725,
-0.007816893048584461,
0.0008795117028057575,
0.020112598314881325,
-0.013238862156867981,
-0.01813580095767975,
-0.011756141670048237,
0.026397794485092163,
-0.041843920946121216,
0.004622017964720726,
-0.023217011243104935,
-0.02206498011946678,
-0.06621350347995758,
0.0395343042910099,
-0.011343330144882202,
-0.00010666847811080515,
0.01509883813560009,
0.0301706213504076,
0.017046388238668442,
-0.012888357974588871,
0.02313161827623844,
-0.013528545387089252,
-0.010343341156840324,
-0.00788811407983303,
0.01282268576323986,
-0.01511272694915533,
-0.0053652198985219,
-0.019419461488723755,
-0.010370948351919651,
0.003671197220683098,
0.008446071296930313,
-0.010380430147051811,
0.021729400381445885,
-0.04521501809358597,
0.009399067610502243,
-0.010686460882425308,
0.012651966884732246,
0.036796923726797104,
0.006543637719005346,
-0.03907965123653412,
-0.019318105652928352,
0.011332018300890923,
0.01124920416623354,
-0.02407430112361908,
-0.00230331439524889,
-0.014996332116425037,
-0.03992956131696701,
-0.011222109198570251,
0.01377424318343401,
0.01771942898631096,
-0.0041816094890236855,
-0.00035441620275378227,
0.0076685091480612755,
-0.004045757465064526,
0.008552738465368748,
0.05663372576236725,
0.003745308145880699,
-0.0021401895210146904,
0.01349116675555706,
0.00835755281150341,
0.012513605877757072,
0.0036494117230176926,
0.012495327740907669,
0.008757434785366058,
0.019498534500598907,
0.01054920069873333,
0.018344782292842865,
0.006339461542665958,
-0.012296140193939209,
0.006108674220740795,
-0.020576614886522293,
0.003182707354426384,
-0.012042520567774773,
-0.0003477940335869789,
-0.0015654746675863862,
0.01155993714928627,
0.0024583032354712486,
-0.00927681289613247,
0.019133463501930237,
-0.03615240752696991,
0.015235691331326962,
0.010667085647583008,
-0.0019238771637901664,
0.02327512949705124,
-0.014497954398393631,
-0.02752348780632019,
-0.006399782374501228,
0.008360358886420727,
0.0072135706432163715,
0.0001264771563000977,
0.01981862261891365,
0.009541202336549759,
0.008858435787260532,
0.026252049952745438,
0.007814438082277775,
0.0078043946996331215,
-0.010747128166258335,
0.022998325526714325,
0.012189578264951706,
-0.014812585897743702,
-0.021381359547376633,
0.004326188005506992,
0.01293656975030899,
-0.0024258883204311132,
-0.018124083057045937,
-0.024738464504480362,
0.022067682817578316,
-0.005725504830479622,
-0.04351430386304855,
0.010411741212010384,
0.010540220886468887,
0.03280094265937805,
-0.012226849794387817,
0.02042170614004135,
-0.015501977875828743,
0.0025440622121095657,
0.005689030047506094,
-0.006968269124627113,
0.024132680147886276,
0.031656041741371155,
0.009050922468304634,
0.004834956955164671,
-0.01441413164138794,
0.0014374034944921732,
0.00638661440461874,
-0.008979993872344494,
0.06596352159976959,
-0.004505608230829239,
0.00891861505806446,
-0.010595133528113365,
0.048268020153045654,
0.011580230668187141,
-0.03800050541758537,
0.01653173938393593,
-0.006030152551829815,
0.0181654691696167,
0.015864070504903793,
-0.018900569528341293,
-0.0037183850072324276,
-0.027102826163172722,
0.011401716619729996,
-0.0009257220663130283,
0.0029337983578443527,
-0.012595558539032936,
0.013144295662641525,
-0.00804890412837267,
0.0006675907643511891,
0.04350212588906288,
0.00022242905106395483,
0.0384989008307457,
-0.027439799159765244,
-0.010779552161693573,
0.013461442664265633,
0.006415355019271374,
-0.012563618831336498,
-0.02799930050969124,
-0.004664199892431498,
0.008928162977099419,
-0.04399153217673302,
-0.03569864481687546,
-0.001308070495724678,
0.006094422657042742,
0.00024146120995283127,
0.026013758033514023,
-0.010999098420143127,
-0.00905662402510643,
-0.01384340226650238,
0.0015013795346021652,
0.03158967196941376,
-0.02513352781534195,
-0.008982843719422817,
0.012373780831694603,
0.02768629975616932,
-0.001570618711411953,
0.0130523182451725,
0.012219260446727276,
0.01608889549970627,
-0.004791945219039917,
-0.026944851502776146,
-0.017801126465201378,
-0.002482949523255229,
0.012810627929866314,
0.01207653060555458,
0.014154832810163498,
-0.02922283671796322,
0.012126755900681019,
-0.016154229640960693,
0.00714536290615797,
-0.012660263106226921,
0.034662097692489624,
-0.011219141073524952,
0.04143301770091057,
-0.015958040952682495,
0.0038051395677030087,
0.02125578559935093,
-0.019555699080228806,
-0.015202781185507774,
0.010204953141510487,
-0.006917927879840136,
0.02249840274453163,
-0.04625743627548218,
0.012655518017709255,
-0.011997891589999199,
0.00915331207215786,
0.021131757646799088,
0.026947475969791412,
0.01587672159075737,
-0.0034105731174349785,
0.006488245911896229,
-0.009846735745668411,
-0.006618333514779806,
-0.024175230413675308,
0.05284818261861801,
0.0048438250087201595,
0.002582993358373642,
-0.01971854642033577,
0.019349131733179092,
0.012456546537578106,
-0.010727005079388618,
-0.006326623260974884,
-0.08162197470664978,
-0.014534560963511467,
0.004680751822888851,
-0.05073288828134537,
0.004706675186753273,
0.009548157453536987,
0.019098281860351562,
-0.007440788671374321,
-0.028582783415913582,
-0.004206592217087746,
0.014733342453837395,
-0.00885881669819355,
-0.006988684181123972,
0.00612871628254652,
0.006793919950723648,
-0.003318249946460128,
0.007647463120520115,
0.015529710799455643,
-0.020416419953107834,
-0.013980899006128311,
-0.00042279367335140705,
0.0060999225825071335,
0.021385950967669487,
0.009511306881904602,
-0.02124917134642601,
-0.006056952755898237,
-0.00713763665407896,
0.015230740420520306,
0.01618022471666336,
0.009508981369435787,
0.0015769265592098236,
-0.021908150985836983,
0.00017036870121955872,
0.004871862009167671,
0.03857298567891121,
0.007733456790447235,
-0.005082113668322563,
-0.0016701724380254745,
-0.02025906927883625,
0.022130001336336136,
-0.028033526614308357,
0.0037059138994663954,
0.013663497753441334,
0.009893074631690979,
0.01684650592505932,
0.003537819255143404,
0.007856233045458794,
-0.008076381869614124,
0.021178200840950012,
-0.004334206692874432,
-0.017893563956022263,
-0.005714071914553642,
0.03217681124806404,
0.027082255110144615,
-0.013565367087721825,
0.02435934729874134,
0.016805682331323624,
-0.006177080329507589,
-0.013794325292110443,
-0.005591179709881544,
-0.008186987601220608,
0.014521591365337372,
0.017207518219947815,
0.011776389554142952,
-0.027361348271369934,
0.0007483810186386108,
0.011089174076914787,
-0.01752961426973343,
-0.018477018922567368,
0.02756422571837902,
0.002720475196838379,
-0.012393355369567871,
-0.0022454517893493176,
-0.006940875202417374,
-0.0006589931435883045,
-0.013955247588455677,
-0.015727607533335686,
-0.026259537786245346,
0.0008533780928701162,
0.018334925174713135,
-0.037974558770656586,
-0.0025520254857838154,
0.004602840635925531,
-0.013866063207387924,
-0.01487031951546669,
-0.012657573446631432,
0.008577052503824234,
-0.013496960513293743,
0.012337025254964828,
-0.018439631909132004,
-0.01575261913239956,
0.02065957896411419,
-0.013290470466017723,
0.01169635821133852,
-0.013042843900620937,
-0.04093604534864426,
-0.01115717925131321,
0.024463556706905365,
0.023302093148231506,
0.010116411373019218,
-0.01239088922739029,
-0.0052361683920025826,
0.017973942682147026,
-0.004092889837920666,
-0.03232540190219879,
0.01987435482442379,
0.0007786571513861418,
-0.026941047981381416,
-0.03193247318267822,
-0.006484916899353266,
-0.025090046226978302,
-0.027242975309491158,
-0.006733505986630917,
-0.002188588958233595,
0.01636441797018051,
-0.023096682503819466,
-0.0010802142787724733,
0.0008319049375131726,
0.07125446200370789,
-0.00006116623990237713,
0.005647961515933275,
-0.01384689100086689,
0.010516982525587082,
-0.03313069045543671,
0.02433905564248562,
0.020759962499141693,
-0.00521595124155283,
0.005524010397493839,
0.014989368617534637,
-0.02973145619034767,
-0.01878153160214424,
-0.006962975487112999,
0.007446529343724251,
-0.005586969666182995,
0.028754934668540955,
-0.019481120631098747,
0.022238513454794884,
0.020782053470611572,
0.012476984411478043,
-0.009372355416417122,
-0.003465913934633136,
-0.01850081980228424,
0.008263736963272095,
-0.03255832940340042,
0.04149477928876877,
-0.011813630349934101,
-0.013769421726465225,
0.008747370913624763,
0.0007208641618490219,
0.0006072288379073143,
-0.00963398814201355,
-0.0005744718946516514,
0.05086122080683708,
-0.01110211294144392,
0.04433128982782364,
-0.004220935516059399,
-0.01443813182413578,
-0.0074615031480789185,
-0.02814910188317299,
-0.01862426847219467,
0.016612447798252106,
-0.0007121996022760868,
-0.03211032971739769,
0.008093565702438354,
0.010140848346054554,
-0.00860726647078991,
-0.000524490256793797,
0.0013218201929703355,
-0.00440997676923871,
-0.005410165525972843,
0.0071189082227647305,
0.019546154886484146,
0.008327890187501907,
0.0007880288176238537,
0.04079188406467438,
-0.009966784156858921,
0.0018105915514752269,
-0.022824976593255997,
-0.023359285667538643,
-0.06212005764245987,
0.02277689054608345,
-0.02585739456117153,
0.008109642192721367,
-0.028244683519005775,
-0.008119086734950542,
-0.005914805456995964,
-0.00925354566425085,
-0.012378104031085968,
-0.0026809305418282747,
0.003480461658909917,
0.007231047842651606,
-0.003076729830354452,
-0.03220671787858009,
0.0008623872417956591,
0.006996018812060356,
-0.017670121043920517,
0.005658561363816261,
-0.005936001427471638,
0.02020040899515152,
-0.00901106558740139,
0.01715090312063694,
-0.010895339772105217,
-0.012344054877758026,
-0.015310379676520824,
-0.03803291916847229,
-0.07408970594406128,
-0.011555826291441917,
-0.00563482940196991,
-0.008813099935650826,
0.014468161389231682,
0.01594429835677147,
-0.025046925991773605,
-0.01747359149158001,
-0.028549393638968468,
0.002245137933641672,
0.01405179500579834,
-0.002420776290819049,
0.02640441246330738,
-0.003960086032748222,
0.01360994204878807,
0.036766957491636276,
-0.019398072734475136,
-0.0027760681696236134,
0.005064626690000296,
-0.009547565132379532,
-0.007635537534952164,
-0.01782195083796978,
-0.04187730327248573,
-0.004837235901504755,
-0.0006858926499262452,
-0.08021876215934753,
-0.0082478616386652,
0.010924169793725014,
-0.007063964381814003,
-0.009161974303424358,
-0.02910798043012619,
0.0034828714560717344,
-0.005054673179984093,
-0.010344484820961952,
-0.017619438469409943,
0.013286923989653587,
0.003175865625962615,
0.0013179122470319271,
0.0091005340218544,
0.026472868397831917,
-0.011450134217739105,
0.010969886556267738,
-0.005619039759039879,
-0.00048316316679120064,
0.010182773694396019,
-0.016593415290117264,
-0.012892339378595352,
-0.010811259970068932,
0.005267542786896229,
-0.012944312766194344,
-0.014709824696183205,
-0.01629018597304821,
0.018245644867420197,
0.006166460923850536,
-0.040797073394060135,
-0.007372099906206131,
-0.021956048905849457,
0.001477590762078762,
-0.007922515273094177,
0.009597459807991982,
-0.021230854094028473,
0.037449195981025696,
-0.013906649313867092,
0.027413684874773026,
-0.017572974786162376,
0.0036360900849103928,
0.007072211243212223,
0.025873742997646332,
0.010366848669946194,
-0.009017568081617355,
-0.01672448217868805,
0.008836893364787102,
-0.005300060845911503,
0.019006192684173584,
-0.00598504114896059,
0.00555505882948637,
-0.02463524416089058,
0.0009830491617321968,
-0.01845371350646019,
0.0008742115460336208,
0.014478378929197788,
-0.0015832289354875684,
-0.006086235865950584,
0.0008741035126149654,
-0.0004488027188926935,
0.0002957229153253138,
-0.005510732065886259,
0.006434251554310322,
0.07100749760866165,
-0.020904213190078735,
0.022872189059853554,
-0.018534597009420395,
-0.002536460757255554,
0.0022525331005454063,
0.032986246049404144,
-0.018914910033345222,
-0.006240443792194128,
-0.030575577169656754,
0.02975352667272091,
-0.008104689419269562,
-0.021376345306634903,
0.015474127605557442,
0.0033990417141467333,
-0.01645931415259838,
-0.0034509864635765553,
0.01635994389653206,
-0.007917343638837337,
0.012144944630563259,
0.005987972021102905,
-0.0005321877542883158,
-0.049269892275333405,
-0.017751947045326233,
0.01742292195558548,
-0.014913440681993961,
0.006631329655647278,
-0.008288801647722721,
-0.02014254778623581,
0.001593019929714501,
0.01034406665712595,
-0.0076644280925393105,
-0.00024201296037063003,
0.03450348973274231,
0.023034729063510895,
0.004331590607762337,
-0.00865255482494831,
0.017590448260307312,
0.013382595032453537,
0.017387809231877327,
0.017940178513526917,
-0.002293490106239915,
-0.006924008019268513,
-0.030317602679133415,
0.028658438473939896,
-0.02795095555484295,
0.031077979132533073,
0.024883268401026726,
0.009018270298838615,
0.004171234089881182,
0.02601892128586769,
-0.0023826691322028637,
0.005090306047350168,
-0.022064801305532455,
0.0016926625976338983,
0.006215031258761883,
-0.024215327575802803,
0.01767447590827942,
0.010538384318351746,
0.040965333580970764,
0.022273197770118713,
-0.009209596551954746,
-0.0067660012282431126,
-0.011934982612729073,
0.03442872315645218,
0.0006386023014783859,
0.0027112653478980064,
-0.02388303354382515,
-0.0005514142103493214,
0.017281103879213333,
-0.019222818315029144,
0.020941268652677536,
0.006359387189149857,
-0.0047347028739750385,
0.032893307507038116,
0.025621309876441956,
0.01688249595463276,
0.017676517367362976,
0.0033548125065863132,
-0.015586637891829014,
-0.012213325127959251,
-0.018888624384999275,
0.0053621502593159676,
0.03558768332004547,
-0.007101360708475113,
0.01827314682304859,
0.018862409517169,
0.009903036057949066,
0.003924342803657055,
0.008385750465095043,
0.00045622000470757484,
0.009104003198444843,
0.005174105521291494,
0.005329093895852566,
0.004898075945675373,
0.03588397428393364,
0.011116964742541313,
0.010775335133075714,
0.020099636167287827,
-0.001092475838959217,
0.0002538771368563175,
-0.020775120705366135,
-0.02736159786581993,
-0.0007249703630805016,
0.0130287054926157,
0.005169892683625221,
0.045164335519075394,
-0.02949617989361286,
-0.0017416826449334621,
-0.003865413833409548,
0.017324194312095642,
-0.012466050684452057,
0.009878503158688545,
-0.0047212811186909676,
0.02913832664489746,
0.020257946103811264,
-0.022621240466833115,
0.0013807890936732292,
-0.002383145038038492,
-0.01563728228211403,
-0.024007393047213554,
0.0029086903668940067,
0.010565795935690403,
0.014298799447715282,
-0.014455091208219528,
-0.03446752950549126,
-0.014486093074083328,
0.006896951701492071,
-0.011966077610850334,
0.0014533286448568106,
0.027635322883725166,
-0.03906014934182167,
0.01359382551163435,
-0.022724324837327003,
0.012016631662845612,
0.005745533853769302,
-0.014649957418441772,
-0.024610649794340134,
-0.00916203297674656,
0.015145756304264069,
-0.012765064835548401,
-0.008181056007742882,
-0.005438963416963816,
-0.013618570752441883,
0.006941742263734341,
-0.02336081489920616,
0.006313515827059746,
0.015670303255319595,
0.0028597109485417604,
-0.004580389708280563,
0.01665109395980835,
0.002100997604429722,
0.011753372848033905,
-0.011650782078504562,
0.009138591587543488,
0.014058255590498447,
-0.007533765397965908,
-0.03517203778028488,
0.012125259265303612,
0.010247686877846718,
0.010234367102384567,
0.007346076890826225,
0.035483770072460175,
0.014584163203835487,
-0.02361467480659485,
0.010483816266059875,
0.004176881164312363,
-0.003936450928449631,
0.01706811785697937,
-0.00440215552225709,
0.014254828914999962,
-0.007023494690656662,
0.027179887518286705,
0.025897860527038574,
-0.0304025299847126,
-0.009126571007072926,
-0.01796763390302658,
0.01204724982380867,
0.00663526076823473,
0.0030649721156805754,
0.027067674323916435,
-0.0012402561260387301,
-0.006081070750951767,
-0.008324958384037018,
-0.010427555069327354,
-0.0020761778578162193,
-0.017896264791488647,
0.014313303865492344,
0.017568496987223625,
0.013557318598031998,
-0.026689987629652023,
0.02995682694017887,
-0.014134193770587444,
0.00208468921482563,
0.0048979176208376884,
-0.02468554675579071,
-0.009395577944815159,
-0.018708476796746254,
0.01547650620341301,
0.013124095275998116,
0.02294202707707882,
-0.022347742691636086
] | [
0.07155923545360565,
-0.03925846517086029,
-0.3861449956893921,
0.07823245227336884,
-0.25787070393562317,
0.2697359025478363,
0.19256502389907837,
-0.3058527708053589,
-0.3703819513320923,
-0.8238359093666077,
0.22149480879306793,
0.10291106253862381,
-0.2429545521736145,
0.41501346230506897,
0.10851637274026871,
0.9000001549720764,
0.0795542523264885,
0.3162233829498291,
-0.22292043268680573,
-0.32909032702445984,
-0.19801373779773712,
-0.32684651017189026,
0.13716618716716766,
0.0003832811489701271,
-0.1815146803855896,
-0.06173764914274216,
0.8160650730133057,
-0.13747897744178772,
0.5482822060585022,
-0.19073408842086792,
-0.02797188237309456,
0.4765028655529022,
-0.3122157156467438,
-0.018573690205812454,
-0.08451905846595764,
-0.2667018473148346,
-0.06111523509025574,
0.20313581824302673,
0.1317666918039322,
-0.14443740248680115,
-0.0775018259882927,
-0.4104638397693634,
-0.25709450244903564,
0.31768301129341125,
-0.09716874361038208,
-0.8122692108154297,
-1.2320818901062012,
0.7272106409072876,
0.00935879535973072,
0.17284005880355835,
0.1781359612941742,
-0.027855752035975456,
-0.24104999005794525,
0.5113642811775208,
-0.08783745765686035,
0.5139915943145752,
-0.21413731575012207,
-0.08382592350244522,
0.3898378312587738,
-0.28495556116104126,
-0.17285412549972534,
-0.166831374168396,
-0.10328466445207596,
0.3361286520957947,
-0.3096013069152832,
0.827466607093811,
0.22971397638320923,
0.3364619314670563,
-0.4244224727153778,
-0.5537984371185303,
-0.17932046949863434,
-0.7004222273826599,
0.019618971273303032,
0.32717326283454895,
0.12318184971809387,
-0.12173141539096832,
-0.18715663254261017,
-0.595382571220398,
0.15801790356636047,
0.4241512715816498,
-0.22682829201221466,
0.17588995397090912,
-0.10392057150602341,
-0.022176122292876244,
0.659845232963562,
0.29577121138572693,
0.044893089681863785,
0.815284252166748,
-0.4874338209629059,
0.06517517566680908,
0.3493053913116455,
0.12108733505010605,
0.5925666093826294,
0.037219028919935226,
0.43481093645095825,
0.5538020730018616,
-0.03337965905666351,
0.03424663096666336,
0.31238728761672974,
-0.07741394639015198,
-0.459090918302536,
-0.3040863275527954,
-0.33211398124694824,
-0.3232898414134979,
-0.8728464841842651,
-0.44415590167045593,
-0.34510502219200134,
-0.9152588248252869,
-0.6528586745262146,
0.07355672121047974,
-0.5120317339897156,
0.2747439444065094,
0.06712376326322556,
-0.18839886784553528,
-0.5653302073478699,
0.2633153796195984,
0.14539305865764618,
-0.6108391284942627,
0.10967785865068436,
0.4896460175514221,
-0.08732308447360992,
1.4630389213562012,
-0.4063499867916107,
0.7412681579589844,
0.10148409754037857,
-0.06063273549079895,
0.6134300231933594,
0.12194386124610901,
-0.30288517475128174,
0.5273603796958923,
0.1935156136751175,
0.6143088340759277,
-0.26472726464271545,
0.015232301317155361,
0.2222442626953125,
-0.12230635434389114,
-0.37614092230796814,
0.35825708508491516,
0.24214105308055878,
-0.48594212532043457,
-0.7102903723716736,
-0.5879472494125366,
0.08028141409158707,
0.18612949550151825,
0.06024228408932686,
-0.08902999758720398,
-0.31535571813583374,
-0.11377473920583725,
0.028672073036432266,
-0.37750643491744995,
0.09986966848373413,
-0.51221764087677,
-0.19862623512744904,
0.4262371063232422,
-0.15774324536323547,
0.7446017861366272,
0.12871454656124115,
-0.05669359862804413,
0.3419681787490845,
0.24295282363891602,
0.5680522918701172,
-0.011993221007287502,
-0.5941213369369507,
-0.1501474678516388,
0.12161289155483246,
0.13940155506134033,
0.22256068885326385,
0.8038564920425415,
-0.007453851867467165,
-0.5386125445365906,
-0.6140826344490051,
-0.2651764750480652,
-0.11377232521772385,
-0.46342822909355164,
0.006653284654021263,
-0.07836729288101196,
0.19459056854248047,
-0.14151997864246368,
0.42221617698669434,
0.5326042175292969,
-0.4464692175388336,
-0.37328577041625977,
-0.1629268378019333,
-0.3349996507167816,
0.4093325734138489,
0.22790344059467316,
0.37947797775268555,
-0.25567978620529175,
0.1493837684392929,
0.4369501769542694,
-0.5234333276748657,
0.19363699853420258,
0.2674655318260193,
-0.6830468773841858,
1.377138376235962,
-0.15093925595283508,
-0.4202500283718109,
1.6303867101669312,
0.43953898549079895,
-0.02680136449635029,
-0.11429008841514587,
-0.06697653234004974,
0.42264923453330994,
0.018344923853874207,
-0.956479012966156,
-0.031144971027970314,
0.05090627819299698,
-0.2243286520242691,
-0.5936087965965271,
0.19478489458560944,
0.7036260962486267,
-0.09089347720146179,
0.025905882939696312,
-0.38309916853904724,
0.2146529257297516,
0.29234498739242554,
-0.05868693068623543,
0.14248496294021606,
-0.37656334042549133,
0.12533411383628845,
0.4175153076648712,
-0.9646077752113342,
0.4853633940219879,
0.8641061186790466,
-0.025243915617465973,
0.7651421427726746,
0.5507916808128357,
-0.007761899847537279,
0.6613420844078064,
-0.44595101475715637,
0.17605647444725037,
-0.46734967827796936,
0.6763344407081604,
-0.4094952642917633,
-0.2776387929916382,
0.15355904400348663,
0.15745025873184204,
-0.26563337445259094,
-0.3746350407600403,
0.15753096342086792,
0.12531036138534546,
0.8574367761611938,
-0.22827377915382385,
0.17504362761974335,
-0.07274424284696579,
-0.32956498861312866,
-0.22049754858016968,
-0.1800696849822998,
-0.4800605773925781,
-0.13628607988357544,
0.21968983113765717,
0.33095818758010864,
0.5428457260131836,
-0.1815260797739029,
0.06055832654237747,
-0.1644851267337799,
0.15786391496658325,
-0.13194997608661652,
0.0038773042615503073,
-0.40446868538856506,
-0.1222207248210907,
0.07102461159229279,
0.24251613020896912,
0.25077933073043823,
-0.19777238368988037,
-0.5028811097145081,
-0.688001275062561,
-0.19853368401527405,
0.019457831978797913,
0.9168662428855896,
0.8444274663925171,
-0.05269942432641983,
-0.5884681940078735,
-0.3209376633167267,
0.299155592918396,
-0.8022205829620361,
-0.06393379718065262,
0.9291097521781921,
-0.728005588054657,
-0.5623580813407898,
-0.11622975021600723,
0.1683489978313446,
0.8523982763290405,
-0.2662716209888458,
-0.5905526876449585,
-0.07306972146034241,
0.14328905940055847,
-0.48143118619918823,
-1.0122177600860596,
0.1728712022304535,
0.10611605644226074,
0.3033452332019806,
-0.2593512535095215,
-0.027608634904026985,
0.3050141930580139,
0.3830665647983551,
-0.14800170063972473,
0.47510826587677,
0.9278795123100281,
0.01823274791240692,
-0.4664861857891083,
-0.09089481830596924,
-0.12782664597034454,
-0.1997632384300232,
-0.015810487791895866,
-0.12806600332260132,
-0.16173677146434784,
0.22310350835323334,
-5.909023761749268,
-0.3499400317668915,
-0.018546611070632935,
0.06689014285802841,
-0.31148460507392883,
0.23696759343147278,
0.860568106174469,
-0.39563584327697754,
0.3179768919944763,
0.03387417271733284,
0.6531321406364441,
0.6385468244552612,
0.1296829879283905,
-0.26338648796081543,
-0.11385758966207504,
0.280830979347229,
0.43989598751068115,
0.2783188223838806,
0.4407308101654053,
-0.22507759928703308,
0.3819897472858429,
0.10254533588886261,
-0.2040119469165802,
0.4948737323284149,
0.19552282989025116,
-0.017231091856956482,
-0.9377346634864807,
-0.0807008370757103,
0.004390962887555361,
0.14192169904708862,
0.2098277062177658,
-0.1956488937139511,
0.07076233625411987,
-0.16187229752540588,
-0.11411770433187485,
-0.03674313426017761,
0.13657139241695404,
-0.26751628518104553,
0.13081781566143036,
-0.2687588036060333,
0.488023966550827,
0.28858646750450134,
-0.03806864470243454,
-0.1625082939863205,
-0.2158387303352356,
-0.4310839772224426,
-0.11373811215162277,
0.5697789788246155,
-0.05119601637125015,
0.6372144818305969,
-0.176364928483963,
-0.06990227848291397,
0.3344757556915283,
0.5842574238777161,
-0.04054753854870796,
0.14001858234405518,
-0.1244957223534584,
0.22277748584747314,
-0.5268805623054504,
0.2095835953950882,
-0.12428245693445206,
-0.36114558577537537,
-0.10600077360868454,
-0.5382382273674011,
0.018135491758584976,
-0.06622826308012009,
-0.39882132411003113,
-0.9710003137588501,
0.3406016230583191,
0.19805382192134857,
-0.7496980428695679,
0.10060059279203415,
0.40599846839904785,
-0.6898511648178101,
0.43724480271339417,
-0.5453681349754333,
-0.18383197486400604,
0.021013755351305008,
-0.4077945649623871,
-0.21439601480960846,
-0.5559048056602478,
-0.6092403531074524,
0.1776876449584961,
-0.07183051854372025,
0.20919843018054962,
0.08611999452114105,
-0.14684396982192993,
-0.12305156141519547,
-0.12152577191591263,
0.4134235680103302,
0.48795294761657715,
-0.1637231707572937,
0.42111143469810486,
0.615458071231842,
0.2389412224292755,
0.7709142565727234,
0.4221511483192444,
0.2459893822669983,
0.4088098108768463,
0.06536489725112915,
0.6893359422683716,
0.0868620052933693,
-0.34792855381965637,
-0.7776076197624207,
-0.23480959236621857,
0.499585896730423,
-0.07567723840475082,
-0.20969049632549286,
0.8886395692825317,
-0.6975650787353516,
-0.06478957831859589,
-0.1709071546792984,
0.0018879249691963196,
-0.015373767353594303,
0.4674573540687561,
-0.3298892378807068,
0.06694848835468292,
0.10640668869018555,
0.5039594769477844,
-0.21137697994709015,
0.6242425441741943,
0.48189228773117065,
-0.5992793440818787,
0.07558870315551758,
0.28682780265808105,
-0.23741811513900757,
0.247554212808609,
0.19590847194194794,
-0.6609681248664856,
-0.36520588397979736,
-0.0000836313483887352,
0.39027610421180725,
-0.508716881275177,
-0.2998824119567871,
0.10661614686250687,
-0.07358800619840622,
-0.16925890743732452,
0.1814371794462204,
0.30265527963638306,
-0.16442939639091492,
0.04239295795559883,
-0.2708629071712494,
-0.4153122305870056,
0.15603186190128326,
-0.23883017897605896,
0.09730032831430435,
0.07988797873258591,
-0.18541494011878967,
-0.34393247961997986,
-0.2725054919719696,
-0.2530469298362732,
-0.5312299728393555,
0.14899609982967377,
0.1860600858926773,
-0.5081912279129028,
0.17101338505744934,
0.5900325775146484,
0.32162243127822876,
0.16734927892684937,
-0.5654948949813843,
0.1552528589963913,
0.01798749901354313,
-1.0630714893341064,
-0.11504104733467102,
0.09808160364627838,
-0.11953716725111008,
0.04849161580204964,
-0.3318510353565216,
-0.296558141708374,
0.4495795667171478,
-0.35078510642051697,
-0.23505403101444244,
-0.10234374552965164,
0.009323102422058582,
-0.22681400179862976,
0.05843476951122284,
-0.06578914076089859,
0.07486746460199356,
-0.5102507472038269,
0.1942571997642517,
0.19086585938930511,
-0.49822139739990234,
-0.12010738253593445,
0.3389979600906372,
0.1930854618549347,
-0.21450810134410858,
-0.03521636500954628,
-0.23555617034435272,
-0.3432314693927765,
-0.2780414819717407,
0.10862846672534943,
0.25543540716171265,
0.2366822063922882,
-0.26970165967941284,
0.05521470308303833,
-0.12961409986019135,
-0.39594724774360657,
-0.22187384963035583,
0.11039172112941742,
-0.77913898229599,
0.2592564821243286,
0.5776265859603882,
-0.680906355381012,
0.3279871642589569,
-0.06375958025455475,
-0.09638318419456482,
-0.13656741380691528,
0.016213156282901764,
0.30049824714660645,
-0.24946042895317078,
-0.21369874477386475,
-0.5730410218238831,
0.3246895968914032,
0.6651350855827332,
-0.08891128748655319,
0.3371291160583496,
0.00648566335439682,
-0.2740887701511383,
-0.08523708581924438,
0.2891916334629059,
0.014111241325736046,
-0.3565811216831207,
-0.09410693496465683,
-0.11285866796970367,
-0.43800121545791626,
0.7202250957489014,
0.33539697527885437,
-1.0383124351501465,
0.16510848701000214,
0.100715272128582,
-0.010961061343550682,
-0.5750848650932312,
0.16975104808807373,
0.2926914691925049,
-0.606712818145752,
-0.6524253487586975,
-0.12065828591585159,
0.07775097340345383,
0.09939190745353699,
0.06809636950492859,
0.14713943004608154,
0.2650546729564667,
-0.40713217854499817,
-0.15024615824222565,
-0.36059314012527466,
-0.1676863580942154,
0.5401003360748291,
-0.5705410838127136,
-0.6760308146476746,
-0.009340795688331127,
-0.30402302742004395,
-0.6352110505104065,
0.16052792966365814,
0.17253153026103973,
0.8536786437034607,
0.33313047885894775,
-0.33852046728134155,
0.054899461567401886,
-0.31385689973831177,
-0.005128103774040937,
-0.06368371099233627,
-0.07308953255414963,
-0.6013516187667847,
-0.24961364269256592,
-0.12100667506456375,
-0.20582635700702667,
-0.04010211303830147,
-0.7634924650192261,
0.14534416794776917,
-0.0017856094054877758,
-0.3020859360694885,
-0.028348561376333237,
0.733960747718811,
0.45010074973106384,
0.2859535813331604,
0.10832575708627701,
-0.2213536500930786,
0.4508121907711029,
0.2629600465297699,
0.24870510399341583,
-0.39548569917678833,
-0.7278956770896912,
0.49556782841682434,
-0.3911282420158386,
0.272365927696228,
-0.3913506269454956,
0.24898985028266907,
-0.38834449648857117,
0.2974627912044525,
-0.2880971431732178,
-0.33874884247779846,
0.1276283860206604,
-0.7105686664581299,
-0.5754207968711853,
0.10935287177562714,
0.1106833890080452,
0.12437266111373901,
0.13435222208499908,
-0.12157750129699707,
-0.33586159348487854,
-0.6933800578117371,
0.7491828799247742,
0.5524094104766846,
-0.43551406264305115,
0.00018053919484373182,
0.23690108954906464,
0.36194899678230286,
0.22896161675453186,
-0.25307101011276245,
0.22365254163742065,
-0.072953961789608,
0.047184064984321594,
0.5936062932014465,
0.15915781259536743,
-0.24842782318592072,
0.4896370470523834,
-0.0013921094359830022,
-0.09920382499694824,
0.36399370431900024,
-0.01301288791000843,
0.4594499170780182,
0.47600167989730835,
0.3837796151638031,
-0.24886979162693024,
-0.5738697648048401,
0.7420664429664612,
-0.23365271091461182,
0.10191141813993454,
0.26067405939102173,
0.7184589505195618,
0.42700061202049255,
0.2420819103717804,
-0.17459236085414886,
0.19807446002960205,
0.48969462513923645,
0.17742814123630524,
0.01347156148403883,
-0.26199811697006226,
-0.46180686354637146,
0.23155175149440765,
0.9600187540054321,
0.28550970554351807,
-0.37756800651550293,
-0.2488338053226471,
-0.09279022365808487,
0.16538885235786438,
0.11837881803512573,
0.10313417762517929,
-0.3032676875591278,
0.07119446992874146,
0.339140385389328,
0.025438878685235977,
-0.43826794624328613,
0.7459703683853149,
-0.581030011177063,
0.05492562800645828,
0.3598199486732483,
-0.4513718783855438,
-0.10301163792610168,
0.16970308125019073,
0.25336796045303345,
0.2337186485528946,
0.07714574784040451,
0.41901257634162903,
-0.20021219551563263,
0.07432856410741806,
0.576958954334259,
0.19489619135856628,
-0.10111475735902786,
-0.24133627116680145,
0.02324531227350235,
-0.2157454937696457,
0.05019629746675491,
0.45128437876701355,
-0.018694482743740082,
-0.17282414436340332,
0.006369092036038637,
-0.011683964170515537,
-0.39499446749687195,
0.27512452006340027,
-0.07037155330181122,
0.03718454763293266,
-0.2749285399913788,
-0.614229679107666,
-0.14803087711334229,
-0.3716142475605011,
-0.48562538623809814,
0.17100077867507935,
0.2500566840171814,
0.21221649646759033,
0.3770051598548889,
-0.32067257165908813,
-0.022019479423761368,
0.4508490562438965,
0.08356146514415741,
0.07807840406894684,
-0.0324307419359684,
0.5607785582542419,
0.08698908984661102,
0.6750626564025879,
0.19362163543701172,
0.19922038912773132,
-0.272213339805603,
0.449592262506485,
-0.6622004508972168,
0.15103788673877716,
-0.3356209695339203,
0.28140926361083984,
-0.6830388307571411,
-0.1592094749212265,
0.701578676700592,
0.35052958130836487,
-0.38945290446281433,
-0.18772117793560028,
-0.45826947689056396,
-0.0030933809466660023,
0.5560997724533081,
-0.8191443085670471,
0.010807220824062824,
-0.4831995368003845,
-0.0013929159613326192,
-0.8351457118988037,
0.7156223654747009,
0.06125551834702492,
-0.4488735496997833,
-0.2806510329246521,
0.5702792406082153,
0.37107160687446594,
-0.023050298914313316,
0.6045093536376953,
-0.03519867733120918,
0.3782433271408081,
-0.6265305280685425,
0.17418386042118073,
-0.715361475944519,
-0.04293157160282135,
-0.27952247858047485,
0.38075828552246094,
0.2611517012119293,
-0.020816750824451447,
0.04041668027639389,
-0.47441595792770386,
0.04112914204597473,
0.3914302885532379,
0.21744662523269653,
-0.013659454882144928,
-0.0783487930893898,
-0.4276067614555359,
-0.21608373522758484,
0.45300623774528503,
0.018910422921180725,
0.07179425656795502,
0.011224156245589256,
0.15439929068088531,
-0.062193091958761215,
0.3202064633369446,
0.1221485584974289,
-0.3673483431339264,
0.22222644090652466,
0.2241808921098709
] |
The tracing of potentially infectious contacts has become an important part of the control strategy for many infectious diseases, from early cases of novel infections to endemic sexually transmitted infections. Here, we make use of mathematical models to consider the case of partner notification for sexually transmitted infection, however these models are sufficiently simple to allow more general conclusions to be drawn. We show that, when contact network structure is considered in addition to contact tracing, standard “mass action” models are generally inadequate. To consider the impact of mutual contacts (specifically clustering) we develop an improvement to existing pairwise network models, which we use to demonstrate that ceteris paribus, clustering improves the efficacy of contact tracing for a large region of parameter space. This result is sometimes reversed, however, for the case of highly effective contact tracing. We also develop stochastic simulations for comparison, using simple re-wiring methods that allow the generation of appropriate comparator networks. In this way we contribute to the general theory of network-based interventions against infectious disease. | [
-0.004165880382061005,
0.019123930484056473,
-0.008753550238907337,
0.011090032756328583,
0.03273685649037361,
0.0012296121567487717,
0.009172878228127956,
-0.023686544969677925,
-0.013116578571498394,
-0.03629794716835022,
0.0035774745047092438,
0.01552011538296938,
-0.011099572293460369,
0.007735442370176315,
0.006666549947112799,
-0.011085724458098412,
-0.009994306601583958,
0.005029313266277313,
0.0050607705488801,
-0.04433024674654007,
-0.008218072354793549,
0.0136545579880476,
0.01050155982375145,
0.006384191103279591,
0.023654049262404442,
-0.007322159595787525,
-0.0030378568917512894,
-0.01080838218331337,
-0.021279681473970413,
-0.013664315454661846,
-0.00828525610268116,
0.0016920631751418114,
0.012155327945947647,
0.055691108107566833,
-0.0006140624172985554,
-0.016322264447808266,
-0.0008299621986225247,
0.031211722642183304,
-0.011877957731485367,
-0.0034532391000539064,
0.005186568945646286,
-0.0037547689862549305,
0.002876774873584509,
0.000478571280837059,
-0.007426037918776274,
0.026575002819299698,
-0.0019226772710680962,
-0.016605153679847717,
-0.0029713776893913746,
0.01205387618392706,
-0.006880464963614941,
0.010237513110041618,
-0.0030423100106418133,
0.029268179088830948,
-0.0060374122112989426,
-0.004056657664477825,
0.019156038761138916,
0.025650352239608765,
0.00017831637524068356,
0.00466947304084897,
-0.002630960661917925,
0.02326177805662155,
0.016378238797187805,
0.0008238637819886208,
-0.004585183225572109,
-0.0673062652349472,
0.015703372657299042,
0.0233982615172863,
0.01175423339009285,
0.014822406694293022,
-0.003193298354744911,
0.006192173808813095,
0.0009735794737935066,
0.020271673798561096,
-0.015683146193623543,
-0.01290513202548027,
-0.008545493707060814,
0.026290517300367355,
-0.006319358479231596,
0.014861850067973137,
-0.00349025777541101,
0.005718600004911423,
0.008022338151931763,
0.016921482980251312,
-0.003185092471539974,
-0.007424626499414444,
-0.012280218303203583,
0.0140990586951375,
0.0049796937964856625,
0.018199795857071877,
0.026435401290655136,
-0.03935100883245468,
-0.004889771807938814,
0.0007491260766983032,
-0.01913452334702015,
-0.02583017759025097,
-0.024410845711827278,
0.012620980851352215,
0.0084565170109272,
0.007961566559970379,
-0.0029322674963623285,
0.013005353510379791,
0.02351381629705429,
0.007146824151277542,
0.012348202988505363,
0.013943139463663101,
-0.026585429906845093,
0.019160613417625427,
0.012173096649348736,
0.00867120735347271,
0.007058726157993078,
0.02314106374979019,
-0.006861242465674877,
0.014032136648893356,
0.0004067172994837165,
0.01574324630200863,
0.004276282154023647,
-0.026485783979296684,
0.00949537381529808,
0.006073891185224056,
-0.01656869612634182,
-0.010766413062810898,
0.005338093265891075,
0.022361012175679207,
0.0069440556690096855,
0.003934779204428196,
-0.03268225118517876,
0.009763128124177456,
0.01596900448203087,
0.01646183803677559,
-0.008996955119073391,
0.009724760428071022,
0.019689951092004776,
-0.005335723981261253,
-0.000969388522207737,
-0.001855926588177681,
0.006921141874045134,
0.033348578959703445,
0.007397392299026251,
-0.02448248490691185,
-0.005823791958391666,
0.010519023984670639,
-0.0001464423257857561,
0.012524377554655075,
0.025599375367164612,
-0.0031921849586069584,
-0.00852072425186634,
0.020624462515115738,
0.0021550243254750967,
0.008171875029802322,
0.018116530030965805,
0.00399768864735961,
0.001907299505546689,
-0.01986163854598999,
-0.013310719281435013,
0.009822255000472069,
-0.008166208863258362,
-0.024322738870978355,
-0.00130899203941226,
-0.0016174083575606346,
0.020589444786310196,
0.0012041741283610463,
0.01749376580119133,
0.009820978157222271,
0.005519301630556583,
0.022975049912929535,
-0.007710718549787998,
0.0008770247222855687,
0.0031993575394153595,
0.0030816488433629274,
-0.005962919443845749,
0.017526451498270035,
-0.003912921994924545,
0.013431093655526638,
-0.0121973417699337,
0.016146013513207436,
0.0026360019110143185,
0.007172272074967623,
-0.010207701474428177,
0.06723219901323318,
0.022235345095396042,
-0.000021843123249709606,
-0.014005999080836773,
0.0000703493133187294,
-0.016299592331051826,
-0.008195998147130013,
0.030896151438355446,
-0.011690298095345497,
0.0036688270047307014,
-0.004431716166436672,
-0.003931641578674316,
-0.012193741276860237,
0.0028331377543509007,
0.0013992366148158908,
-0.016504723578691483,
0.0034111645072698593,
0.0060690948739647865,
-0.002997082192450762,
0.015576589852571487,
0.0017055023927241564,
-0.017639964818954468,
0.002090617548674345,
0.014870223589241505,
0.014045639894902706,
-0.0012119434541091323,
0.007280722260475159,
0.005135885439813137,
-0.007963716052472591,
0.008515052497386932,
-0.0021390565671026707,
0.025205885991454124,
0.0016138432547450066,
0.007034459616988897,
-0.006808395963162184,
-0.012184420600533485,
-0.004621901549398899,
0.010565600357949734,
0.01636606454849243,
0.0134364552795887,
-0.013799075037240982,
0.0042238435707986355,
0.0108198132365942,
0.0048859440721571445,
-0.0016949886921793222,
0.011116748675704002,
0.023464180529117584,
0.0022493256255984306,
0.010538659058511257,
0.012899518013000488,
-0.006065020337700844,
-0.0023673332761973143,
-0.023481296375393867,
-0.0076775941997766495,
0.017322750762104988,
0.00029127998277544975,
0.00703376205638051,
0.01077425479888916,
-0.011133022606372833,
0.01453193835914135,
-0.008740546181797981,
-0.015672165900468826,
0.0011373760644346476,
0.010929808020591736,
-0.0033546723425388336,
-0.00532276788726449,
-0.010935582220554352,
0.0020028434228152037,
0.011198042891919613,
0.003612972330302,
-0.009651480242609978,
0.0027803094126284122,
0.0009110311511904001,
-0.009706061333417892,
0.014135248959064484,
0.029519595205783844,
-0.011848147958517075,
0.017014527693390846,
0.011643756181001663,
0.02268822491168976,
-0.00734966155141592,
0.005408656317740679,
0.004784537013620138,
-0.026500238105654716,
0.009403184056282043,
0.00913929007947445,
0.01129128411412239,
0.01552865095436573,
0.05220033973455429,
0.014094572514295578,
0.0179999228566885,
0.003163703018799424,
-0.0029530024621635675,
0.0016307313926517963,
-0.08142751455307007,
-0.019038036465644836,
0.0022865221835672855,
-0.004252278245985508,
0.011256868951022625,
-0.003633511019870639,
-0.0016278550028800964,
-0.0010822266340255737,
-0.009824191220104694,
0.02266247570514679,
0.011840973049402237,
0.020665697753429413,
-0.013407736085355282,
-0.0006981517653912306,
0.010644237510859966,
-0.004959407728165388,
0.0029774666763842106,
0.012901597656309605,
0.0001780753955245018,
-0.006263253279030323,
-0.0033453800715506077,
-0.0147043876349926,
-0.03215058892965317,
0.0021845062728971243,
0.0022422997280955315,
0.008697973564267159,
0.02405468001961708,
-0.010454334318637848,
0.0028024055063724518,
0.010692982003092766,
0.019335582852363586,
-0.009727245196700096,
-0.0020684751216322184,
-0.025675557553768158,
0.023890458047389984,
-0.018629983067512512,
-0.0020530899055302143,
-0.011001496575772762,
-0.006269384641200304,
0.0005798935890197754,
0.001379869063384831,
0.01591254025697708,
0.008158912882208824,
0.02084932290017605,
0.011016933247447014,
0.0026642377488315105,
0.035752445459365845,
0.009432045742869377,
0.007850585505366325,
0.0063673448748886585,
0.025824062526226044,
0.0015442735748365521,
-0.008435381576418877,
0.009112490341067314,
-0.00615874957293272,
-0.0028728318866342306,
-0.00372304767370224,
0.00675750058144331,
-0.013139639049768448,
-0.013181018643081188,
-0.009921645745635033,
-0.024996008723974228,
-0.019519833847880363,
0.006565094459801912,
-0.017219990491867065,
-0.015628548339009285,
0.011463993228971958,
-0.009800871834158897,
-0.010235515423119068,
-0.0029875393956899643,
-0.00023712054826319218,
-0.004177424591034651,
-0.009526817128062248,
0.0009370498592033982,
-0.011207643896341324,
-0.007876302115619183,
-0.018045056611299515,
-0.0058256108313798904,
-0.014572996646165848,
0.016789590939879417,
0.006780184805393219,
0.01724187098443508,
-0.01894330233335495,
-0.009455502033233643,
-0.018630702048540115,
-0.0031220533419400454,
0.008913586847484112,
-0.00026495568454265594,
0.008877577260136604,
-0.01092855166643858,
0.030685417354106903,
-0.01352410577237606,
-0.029049102216959,
0.0069223325699567795,
0.0039048579055815935,
-0.015363297425210476,
0.015105189755558968,
0.013214212842285633,
0.004014262929558754,
0.010673942044377327,
0.011657814495265484,
-0.00022737192921340466,
0.011322394013404846,
-0.014364298433065414,
-0.02643251046538353,
0.015011635608971119,
-0.002931980649009347,
-0.0028097322210669518,
-0.00665775453671813,
-0.002927213441580534,
-0.005707218777388334,
0.006578621454536915,
-0.005749772302806377,
0.023610539734363556,
0.008902795612812042,
0.025836775079369545,
0.014684230089187622,
0.0033190539106726646,
0.0726437121629715,
-0.01961512863636017,
0.013007430359721184,
-0.0068459040485322475,
-0.04137872904539108,
-0.028773227706551552,
-0.0016690280754119158,
0.016345182433724403,
-0.00291269738227129,
-0.0068255397491157055,
0.010800309479236603,
-0.018206655979156494,
0.0069991210475564,
0.011827375739812851,
0.0052561997435987,
-0.024609392508864403,
0.010822085663676262,
0.014050151221454144,
0.002280512824654579,
-0.007810708601027727,
-0.000563744455575943,
-0.01411113329231739,
0.0003191349096596241,
0.01292075589299202,
-0.011479874141514301,
-0.01774890348315239,
0.018848497420549393,
-0.015102905221283436,
-0.00344478408806026,
0.002494923770427704,
0.018467433750629425,
0.004848729353398085,
-0.001513806520961225,
-0.0192502923309803,
0.011023740284144878,
-0.016908112913370132,
0.013624509796500206,
0.014628896489739418,
0.003760274965316057,
0.007893851958215237,
0.010403500869870186,
-0.015709225088357925,
0.008037094958126545,
0.021919701248407364,
-0.029259543865919113,
0.001352805644273758,
-0.01122127566486597,
-0.0036260895431041718,
-0.007039218209683895,
0.007225587964057922,
-0.00582851329818368,
0.01597665436565876,
0.016480881720781326,
0.027436334639787674,
0.012653117999434471,
0.001090401317924261,
-0.008904362097382545,
0.0060293241403996944,
0.014765763655304909,
0.0023625229950994253,
-0.008400654420256615,
-0.005788981448858976,
0.004208019468933344,
-0.039598360657691956,
0.010213449597358704,
-0.003246448002755642,
-0.013945802114903927,
-0.0015322627732530236,
-0.014772962778806686,
0.012561708688735962,
0.01526387594640255,
-0.03483617305755615,
-0.0037447656504809856,
-0.005591873079538345,
-0.021381422877311707,
-0.00837178248912096,
-0.010819284245371819,
-0.012023389339447021,
0.0076233153231441975,
-0.010795244947075844,
0.015422535128891468,
-0.009974666871130466,
-0.014184100553393364,
0.0012464519822970033,
-0.016581375151872635,
-0.0017076022922992706,
-0.020319385454058647,
-0.07467620074748993,
0.01361982524394989,
0.00003332173218950629,
-0.009912371635437012,
0.006785050965845585,
-0.013020509853959084,
-0.0009304839186370373,
0.0008953274227678776,
-0.005234979558736086,
-0.006710214540362358,
-0.02023041620850563,
0.005499064922332764,
0.003458689898252487,
-0.0026114440988749266,
0.012361107394099236,
0.011992862448096275,
-0.01669873110949993,
-0.012100085616111755,
-0.016018575057387352,
0.021725401282310486,
-0.0065605551935732365,
0.023454710841178894,
-0.004453735426068306,
-0.004588843323290348,
0.0018597174203023314,
-0.08157073706388474,
-0.009404949843883514,
0.008071686141192913,
-0.007430716883391142,
-0.008862769231200218,
0.0024973454419523478,
0.0023669025395065546,
-0.028442028909921646,
0.0027818619273602962,
-0.01357509009540081,
-0.016114190220832825,
-0.0030267061665654182,
-0.03258132562041283,
0.0006605812814086676,
-0.005527785047888756,
-0.0022337189875543118,
0.022788582369685173,
-0.01359175331890583,
0.005555108189582825,
-0.006005423609167337,
0.0010675324592739344,
0.03306213393807411,
-0.007344036363065243,
0.012514475733041763,
-0.010585698299109936,
0.0022588633000850677,
-0.014329187572002411,
0.010701810009777546,
0.0128713920712471,
0.010043222457170486,
0.013921668753027916,
0.018608935177326202,
0.016645628958940506,
-0.01252856757491827,
0.003015304682776332,
-0.016514722257852554,
-0.000986327650025487,
0.013984644785523415,
0.01205036323517561,
-0.005079795140773058,
-0.004893582779914141,
0.017635103315114975,
-0.02965248003602028,
-0.026137880980968475,
0.0121652502566576,
0.0029695574194192886,
0.004024668596684933,
-0.003420902183279395,
0.0047586774453520775,
0.013625990599393845,
0.009943166747689247,
-0.017308348789811134,
0.017472755163908005,
-0.011468588374555111,
0.02958124503493309,
0.02137860283255577,
-0.007070006337016821,
0.02323395013809204,
-0.005223897285759449,
0.026794129982590675,
0.0074515510350465775,
0.010231970809400082,
-0.0029156007803976536,
0.07215747237205505,
-0.034655600786209106,
-0.002176772803068161,
0.014482448808848858,
0.0000744764693081379,
-0.0010192000772804022,
-0.026646235957741737,
-0.00653630867600441,
0.008956901729106903,
-0.02732863277196884,
-0.0036805584095418453,
-0.004861917346715927,
-0.013108759187161922,
0.008760232478380203,
0.023212052881717682,
-0.01182897575199604,
0.0032912292517721653,
0.005704536102712154,
-0.0011868402361869812,
0.007034771144390106,
-0.011551400646567345,
0.00612923176959157,
-0.017867235466837883,
0.019127855077385902,
0.0002127746120095253,
0.004176713526248932,
-0.010818575508892536,
-0.015598814934492111,
-0.013193177059292793,
-0.00679190456867218,
-0.004985621199011803,
0.005811146926134825,
0.004079312086105347,
0.01614987850189209,
0.030140958726406097,
-0.01244642399251461,
0.012601567432284355,
-0.008350921794772148,
-0.011350695043802261,
0.003645697608590126,
-0.019573736935853958,
-0.020148374140262604,
0.0013675759546458721,
0.010430974885821342,
0.002864660695195198,
0.009905807673931122,
0.009869894944131374,
0.017089245840907097,
0.01318662241101265,
0.016407417133450508,
-0.006709116976708174,
0.0030472311191260815,
0.006770038977265358,
-0.0002567656338214874,
-0.0071154311299324036,
0.0075600845739245415,
0.010800350457429886,
0.019034110009670258,
-0.01167011633515358,
-0.02069782093167305,
0.0017461847746744752,
-0.011737197637557983,
-0.015551567077636719,
-0.0023874081671237946,
-0.004233069252222776,
-0.005066389683634043,
0.007152876816689968,
-0.01021295040845871,
-0.01840272545814514,
0.015809858217835426,
-0.004322965629398823,
0.018537752330303192,
0.0046540237963199615,
0.0000975998118519783,
0.01254331972450018,
0.008184281177818775,
-0.0035233779344707727,
-0.008794989436864853,
0.0002520086709409952,
0.008468931540846825,
-0.007440890185534954,
0.011557694524526596,
0.003170376643538475,
-0.005992181599140167,
0.007107855752110481,
0.00506633659824729,
-0.005868933163583279,
0.020887453109025955,
-0.014522094279527664,
0.004166868980973959,
0.017202237620949745,
0.013066492043435574,
-0.0008056845981627703,
0.011993179097771645,
0.007041916251182556,
0.033463068306446075,
-0.022356342524290085,
0.0012185057858005166,
0.019871044903993607,
0.004157799296081066,
0.017201567068696022,
0.0013569474685937166,
0.008234244771301746,
-0.010331429541110992,
-0.025495130568742752,
0.008226699195802212,
0.009732053615152836,
-0.004097973927855492,
-0.009357798844575882,
0.0015730811282992363,
-0.010829281993210316,
-0.00613015703856945,
0.003453140379860997,
0.006598827429115772,
-0.017942197620868683,
0.002101641148328781,
-0.00179972592741251,
0.01775404065847397,
-0.0053850458934903145,
-0.0035270466469228268,
-0.025085415691137314,
0.005586234852671623,
-0.030659545212984085,
0.019426478073000908,
0.008348897099494934,
-0.018888328224420547,
-0.004192916210740805,
-0.016964880749583244,
0.002910736482590437,
0.020947188138961792,
0.006655625533312559,
-0.005057837348431349,
-0.008794165216386318,
0.0011599669232964516,
-0.001513404306024313,
-0.01152761373668909,
-0.0029771588742733,
0.0004253205843269825,
0.023287825286388397,
-0.02197623997926712,
0.013282228261232376,
-0.020050909370183945,
0.00176004390232265,
-0.009868677705526352,
0.007319021038711071,
0.007835960946977139,
0.008530579507350922,
0.01578526943922043,
0.008984368294477463,
0.006688039284199476,
-0.008590765297412872,
0.012722412124276161,
-0.0003149835392832756,
-0.004063758533447981,
-0.022087348625063896,
0.017568230628967285,
0.015783842653036118,
-0.01781546324491501,
-0.02060350775718689,
0.0004909580457024276,
-0.022024989128112793,
-0.013735797256231308,
-0.008340497501194477,
0.013692663982510567,
0.007974110543727875,
0.011631099507212639,
0.007690738886594772,
0.02293514460325241,
-0.006315076723694801,
0.010989811271429062,
0.00497319595888257,
-0.005349139682948589,
-0.02644418179988861,
0.013643236830830574,
-0.02330300584435463,
-0.022664885967969894,
0.00469272630289197,
0.010432662442326546,
-0.0165506973862648,
-0.0005369868595153093,
0.015458689071238041,
-0.02328312397003174,
0.0175818782299757,
-0.010632111690938473,
-0.0069961706176400185,
-0.009712901897728443,
0.0003515948774293065,
-0.0052962335757911205,
0.010118473321199417,
0.00814901851117611,
-0.00788167119026184,
-0.008018994703888893,
-0.010231181979179382,
0.009235279634594917,
0.0001421780325472355,
0.016548294574022293,
0.008721898309886456,
0.00522645702585578,
0.005795501172542572,
-0.010062022134661674,
0.0031695226207375526,
-0.008159652352333069
] | [
0.1595020294189453,
-0.47867870330810547,
0.0687926635146141,
0.14319990575313568,
0.1776721477508545,
-0.1441970020532608,
0.13011722266674042,
-0.15851788222789764,
-0.16300997138023376,
-0.8618022799491882,
0.04947822913527489,
0.39998921751976013,
-0.39251840114593506,
0.13251261413097382,
-0.19816617667675018,
0.3803265392780304,
0.27712875604629517,
0.274393230676651,
-0.5005558729171753,
-0.449680894613266,
-0.6755147576332092,
-0.04472658038139343,
-0.07435808330774307,
-0.04546282812952995,
-0.072098009288311,
0.4075027406215668,
0.40745455026626587,
0.4227815866470337,
0.10286065936088562,
-0.34229207038879395,
0.5058847665786743,
0.284859299659729,
-0.23425187170505524,
-0.3142282962799072,
-0.41002997756004333,
-0.5104491114616394,
-0.017129328101873398,
-0.6441013216972351,
-0.364368736743927,
-0.442190021276474,
-0.005302807781845331,
0.17428411543369293,
-0.680887758731842,
0.41153889894485474,
0.2173420786857605,
-0.5707930326461792,
-1.5290371179580688,
0.3134683072566986,
0.04984692856669426,
-0.1347382813692093,
-0.19459079205989838,
0.2616228461265564,
0.3101085126399994,
0.4126892685890198,
0.010276654735207558,
0.20700603723526,
-0.48054590821266174,
-0.3470478653907776,
0.22127710282802582,
-0.05249151587486267,
-0.07664406299591064,
-0.24951934814453125,
0.11908608675003052,
0.5097370743751526,
-0.08916280418634415,
0.2674143314361572,
0.28879690170288086,
-0.04269003868103027,
-0.27898648381233215,
-0.4950072467327118,
0.19364026188850403,
-0.39284881949424744,
-0.09973440319299698,
0.302051842212677,
-0.3934836685657501,
-0.03666805848479271,
0.02213946357369423,
-0.42658060789108276,
0.2649805545806885,
-0.0485328808426857,
-0.26102861762046814,
0.02235535904765129,
0.22012506425380707,
-0.5707562565803528,
1.0222728252410889,
0.0645027607679367,
-0.12903577089309692,
0.37570369243621826,
-0.3099346160888672,
0.2531526982784271,
0.1227383092045784,
-0.5262307524681091,
-0.0038428304251283407,
0.04783425107598305,
0.5826066732406616,
0.39049509167671204,
0.006521302741020918,
0.08536757528781891,
0.5685921311378479,
0.36747944355010986,
0.11696964502334595,
-0.23513349890708923,
0.1523013412952423,
-0.424574613571167,
-0.2118535190820694,
-0.7006757259368896,
-0.26230761408805847,
-0.3069394528865814,
-0.42677682638168335,
0.02311667427420616,
-0.4528792202472687,
0.2666584551334381,
0.3256206512451172,
0.073512963950634,
-0.4246980845928192,
0.1211484894156456,
0.16616226732730865,
0.0035963160917162895,
-0.2839691638946533,
0.10534757375717163,
-0.2692832350730896,
1.0023022890090942,
0.2228754758834839,
0.7663591504096985,
0.18535257875919342,
0.2681891620159149,
0.6415677070617676,
0.5150525569915771,
-0.8073520064353943,
0.18381604552268982,
0.01606329157948494,
0.7665878534317017,
-0.23341865837574005,
0.055411919951438904,
-0.14591994881629944,
-0.49771907925605774,
-0.024334797635674477,
0.4523298144340515,
0.30181750655174255,
-0.0805826261639595,
-0.6295560002326965,
-0.5693650841712952,
0.06910116225481033,
0.18517041206359863,
0.2506412863731384,
-0.15175005793571472,
-0.029951700940728188,
-0.35826995968818665,
-0.08526633679866791,
-0.04380093142390251,
-0.2599810063838959,
0.15601342916488647,
-0.6568750143051147,
-0.09605944901704788,
-0.35454168915748596,
0.7481241822242737,
0.27462974190711975,
0.027205562219023705,
-0.062687948346138,
0.10433779656887054,
0.2780848443508148,
0.12586285173892975,
-0.6061226725578308,
0.05716479569673538,
0.5241672396659851,
-0.456391304731369,
-0.11240341514348984,
0.22648128867149353,
0.5138798952102661,
0.27512916922569275,
-0.07609980553388596,
0.04555092379450798,
-0.4309835135936737,
-0.7771009206771851,
0.20283782482147217,
0.024063443765044212,
-0.1511472910642624,
-0.0711924359202385,
0.27655577659606934,
-0.1473550945520401,
-0.7383188605308533,
0.2074504941701889,
0.12347035109996796,
-0.7876614332199097,
-0.19367656111717224,
0.17483051121234894,
0.05721797049045563,
-0.07160835713148117,
-0.6173305511474609,
-0.15864594280719757,
-0.07873497158288956,
-0.42286914587020874,
0.3061871826648712,
-0.9149255752563477,
1.375508427619934,
-0.15195170044898987,
0.05466119199991226,
1.3318262100219727,
0.14801305532455444,
-0.3051988482475281,
-0.00008204780169762671,
0.13618691265583038,
0.31114664673805237,
0.23525291681289673,
-0.9223918914794922,
0.08194535225629807,
-0.03372606635093689,
-0.21209600567817688,
-0.36512792110443115,
0.00526630412787199,
0.4205968677997589,
-0.19992217421531677,
-0.12321209162473679,
-0.3777305781841278,
0.16449671983718872,
0.27299413084983826,
-0.2892901599407196,
0.35880178213119507,
0.08458571135997772,
0.16845712065696716,
0.4188160002231598,
-0.7036423087120056,
0.3442804515361786,
0.9109737277030945,
0.06063222140073776,
0.7490091323852539,
0.5417685508728027,
0.4233872592449188,
0.876358687877655,
-0.6151255369186401,
-0.13049086928367615,
-0.04878964275121689,
0.5784640312194824,
-0.6374639868736267,
-0.3447588086128235,
-0.15512977540493011,
0.1791471540927887,
-0.5727282762527466,
-0.31991046667099,
0.1322261542081833,
0.03893173858523369,
0.3760358989238739,
-0.33417487144470215,
0.396034300327301,
0.021335318684577942,
-0.22856780886650085,
-0.3950585722923279,
-0.15839709341526031,
0.17371322214603424,
0.13835160434246063,
0.22086836397647858,
0.5092446208000183,
0.18510758876800537,
-0.9677783250808716,
0.2903066575527191,
0.07121431827545166,
-0.3844866156578064,
-0.5152140855789185,
0.22787711024284363,
-0.2786596119403839,
0.24720142781734467,
0.1225401982665062,
-0.17382484674453735,
0.456485390663147,
0.0034640918020159006,
-0.5428882241249084,
-0.7478433847427368,
-0.3155665695667267,
0.5970949530601501,
0.6668319702148438,
0.5303536057472229,
-0.10151584446430206,
-0.47099924087524414,
-0.15864276885986328,
-0.29035434126853943,
-0.5115653276443481,
0.06605635583400726,
0.7318629622459412,
-0.5855965614318848,
-0.36003410816192627,
-0.25859251618385315,
0.3309503495693207,
0.4238587021827698,
-0.3639334738254547,
-0.5257225632667542,
-0.40333467721939087,
0.24021871387958527,
-0.12476778775453568,
-0.5519023537635803,
0.08853517472743988,
-0.014065749011933804,
0.5068064332008362,
-0.1463744193315506,
0.03555138781666756,
0.38087427616119385,
0.4342670142650604,
-0.17642748355865479,
0.2428775578737259,
0.41658103466033936,
-0.29967233538627625,
-0.0012563324999064207,
0.4466674327850342,
-0.26754361391067505,
-0.18276900053024292,
0.00698809465393424,
-0.1860933005809784,
-0.4022936224937439,
0.36932098865509033,
-6.011841773986816,
-0.15391066670417786,
-0.4246573746204376,
0.10675127059221268,
-0.5240848064422607,
0.13818742334842682,
1.3034948110580444,
-0.17883701622486115,
0.4365379512310028,
0.028345033526420593,
0.1928478330373764,
0.5609419345855713,
0.27577269077301025,
0.06929979473352432,
0.06950964778661728,
0.23549848794937134,
0.03123452141880989,
-0.18316975235939026,
0.35571467876434326,
0.16603530943393707,
-0.002991176676005125,
-0.04421411454677582,
0.015355630777776241,
0.7722600698471069,
-0.31336265802383423,
0.06416738033294678,
-0.6917527914047241,
0.2544831335544586,
-0.025927351787686348,
0.08126157522201538,
0.2748231589794159,
-0.2823822498321533,
-0.23417572677135468,
-0.10208311676979065,
0.010881512425839901,
0.1859990954399109,
0.6267226338386536,
-0.06993972510099411,
-0.3664800822734833,
-0.17124541103839874,
0.2589331567287445,
0.6892172694206238,
0.02055339328944683,
0.18708953261375427,
0.13858634233474731,
-0.18257930874824524,
-0.01919839158654213,
0.07552201300859451,
-0.11330268532037735,
1.0118589401245117,
-0.4021967649459839,
-0.020327841863036156,
0.18639792501926422,
0.25739574432373047,
0.09221072494983673,
-0.3061586022377014,
0.07109614461660385,
-0.3342975080013275,
-0.5279479026794434,
0.5177667737007141,
0.12835955619812012,
-0.5202546715736389,
0.5332661271095276,
-0.6698144674301147,
0.013664612546563148,
0.4142323434352875,
-1.0310273170471191,
-0.9518126249313354,
0.058073967695236206,
-0.25766506791114807,
-0.5474229454994202,
0.34198763966560364,
0.13655081391334534,
-0.4777388572692871,
0.3846863806247711,
-0.26361915469169617,
0.15458086133003235,
0.1035669818520546,
0.364886075258255,
-0.12476453930139542,
-0.11571720242500305,
-0.20384913682937622,
0.17246323823928833,
0.1711045503616333,
0.26959991455078125,
-0.21709834039211273,
-0.0435003824532032,
-0.1588105857372284,
-0.3098214566707611,
-0.1610681116580963,
0.41604894399642944,
-0.056545332074165344,
0.326876699924469,
0.33153602480888367,
0.5395665168762207,
1.1160523891448975,
0.10533284395933151,
0.12536537647247314,
0.3332327604293823,
-0.4242216944694519,
0.7189871072769165,
0.1146877184510231,
-0.44382762908935547,
-0.7455407977104187,
0.14229342341423035,
0.04412480443716049,
0.28310585021972656,
0.153749480843544,
0.23053430020809174,
-0.4784587621688843,
-0.025899292901158333,
-0.18171697854995728,
-0.5991191267967224,
-0.27807343006134033,
0.06632570177316666,
-0.1695980727672577,
-0.053711630403995514,
-0.19824936985969543,
0.4675956666469574,
-0.1327238380908966,
-0.15137310326099396,
0.32088902592658997,
-0.05390751734375954,
0.504541277885437,
0.49927598237991333,
-0.7463111281394958,
-0.14890635013580322,
0.4738909900188446,
0.13770568370819092,
0.04525424912571907,
0.27454832196235657,
0.4973677098751068,
-0.25060755014419556,
-0.30284640192985535,
0.2756801247596741,
-0.5511172413825989,
-0.14485284686088562,
0.055105675011873245,
0.024618815630674362,
-0.3686203062534332,
-0.12334643304347992,
-0.23073893785476685,
-0.41225895285606384,
0.26488056778907776,
0.38186952471733093,
-0.19787372648715973,
-0.49382254481315613,
-0.1664249449968338,
-0.01582699455320835,
0.15699660778045654,
-0.39897677302360535,
-0.4505108892917633,
0.3307870626449585,
-0.29118582606315613,
0.04242468625307083,
0.19094091653823853,
0.7067094445228577,
0.08498050272464752,
0.1921737641096115,
-0.4163234233856201,
0.09838040173053741,
0.0442546047270298,
-0.49432843923568726,
0.3874424993991852,
0.06636376678943634,
0.32178589701652527,
-0.7121591567993164,
-0.5750517249107361,
-0.15838423371315002,
0.1276034712791443,
-0.3669033944606781,
-0.5866853594779968,
-0.3855324983596802,
-0.2770408093929291,
-0.030080009251832962,
-0.05940546095371246,
-0.1359023153781891,
0.7117730975151062,
-0.3760983943939209,
-0.07145873457193375,
-0.2249552309513092,
-0.3369823694229126,
-0.4372851252555847,
0.420936644077301,
0.5670742988586426,
0.2994794547557831,
0.25352591276168823,
0.008635458536446095,
-0.4305769205093384,
-0.08070969581604004,
0.42900350689888,
0.5742951035499573,
0.06109798327088356,
0.038730256259441376,
0.033351048827171326,
-0.4853908121585846,
0.15381202101707458,
-0.03741613030433655,
-0.17005452513694763,
-0.3421702980995178,
0.2737419605255127,
0.5772713422775269,
-0.4187512695789337,
0.3478604555130005,
-0.05941430479288101,
-0.15392549335956573,
0.3235715627670288,
0.0937565416097641,
-0.0466776117682457,
-0.3045974671840668,
-0.3325721025466919,
-0.39973294734954834,
0.05691492184996605,
0.4477992057800293,
-0.4369395673274994,
0.049427106976509094,
0.3591332733631134,
-0.28006377816200256,
-0.19949980080127716,
0.5469537377357483,
0.4240643084049225,
-0.2095491588115692,
-0.499961793422699,
-0.14603592455387115,
-0.23086708784103394,
0.33042430877685547,
0.5757725834846497,
-0.7939871549606323,
-0.12645764648914337,
0.757752537727356,
-0.3066570460796356,
-0.1695900410413742,
0.24648569524288177,
0.19958889484405518,
-0.43421313166618347,
-0.11108327656984329,
-0.29661476612091064,
0.2739693522453308,
0.38021373748779297,
0.20044881105422974,
0.43653401732444763,
0.7316057682037354,
-0.01264253444969654,
-0.6134018301963806,
-0.05034288391470909,
0.29172953963279724,
0.4108511507511139,
-0.7418112754821777,
-0.9846724271774292,
0.1976572573184967,
0.2869013249874115,
-0.06871506571769714,
0.062345463782548904,
-0.1347229927778244,
0.3376997411251068,
0.05377678945660591,
-0.45684024691581726,
-0.18293675780296326,
0.2082654982805252,
0.4201456904411316,
-0.25375571846961975,
-0.2677479088306427,
-0.6258441805839539,
-0.8229087591171265,
0.5230873823165894,
-0.017409585416316986,
-0.28231170773506165,
-0.4696619212627411,
-0.283051073551178,
-0.4750162363052368,
-0.023668929934501648,
-0.4584085941314697,
0.6777859330177307,
0.35136812925338745,
0.1109371930360794,
-0.24091355502605438,
0.01572786644101143,
0.38918668031692505,
-0.1968076378107071,
0.23973847925662994,
-0.18934494256973267,
-0.6468433737754822,
0.10885988175868988,
-0.3764354884624481,
0.3827148377895355,
0.07624055445194244,
0.20964974164962769,
-0.09723890572786331,
0.13356103003025055,
-0.33817553520202637,
-0.2814071774482727,
0.05333855003118515,
-0.7431250810623169,
0.36694544553756714,
0.1306913197040558,
0.13613595068454742,
0.395435631275177,
0.4549129009246826,
-0.02557775378227234,
-0.14557257294654846,
-0.0551738440990448,
0.6412085294723511,
0.1748936027288437,
-0.7157511115074158,
0.07216586172580719,
0.36108726263046265,
0.37335601449012756,
0.018397292122244835,
0.3072848618030548,
0.35562074184417725,
0.3684542179107666,
-0.08476047962903976,
0.2634972035884857,
0.733932614326477,
-0.3230826258659363,
0.35996225476264954,
0.16369277238845825,
-0.2741972506046295,
0.6438866853713989,
-0.1038186252117157,
-0.026406163349747658,
0.489034503698349,
0.5051944851875305,
-0.12415789812803268,
-0.16307313740253448,
0.31139010190963745,
-0.13628055155277252,
0.5949280261993408,
0.16317619383335114,
0.21383865177631378,
0.7168675661087036,
0.9362491965293884,
0.0066824317909777164,
0.12022634595632553,
0.19008664786815643,
0.20982111990451813,
0.29286709427833557,
-0.4449496269226074,
-0.1441892385482788,
0.25891372561454773,
0.6284852623939514,
0.2680697739124298,
-0.14453235268592834,
-0.06404662132263184,
-0.33438944816589355,
0.2741526961326599,
0.58399897813797,
0.39673325419425964,
-0.19553330540657043,
0.3599913716316223,
0.20668546855449677,
-0.052955545485019684,
-0.4731194078922272,
0.1299433410167694,
-0.3177246153354645,
-0.3960839509963989,
0.13148616254329681,
-0.3553657829761505,
-0.20349113643169403,
0.023816687986254692,
0.23859940469264984,
0.49633118510246277,
-0.3130268454551697,
0.07180848717689514,
-0.22569340467453003,
-0.007621713448315859,
0.9843162298202515,
-0.03602243959903717,
0.1940978318452835,
0.022905539721250534,
0.09311989694833755,
0.0671846866607666,
-0.2527625858783722,
0.48172953724861145,
-0.1406252533197403,
-0.7851483225822449,
0.2587544918060303,
0.12671791017055511,
-0.13556097447872162,
0.06901877373456955,
-0.18359625339508057,
0.18353435397148132,
-0.08056463301181793,
-0.4759775996208191,
-0.07107528299093246,
-0.4371523857116699,
-0.4278593957424164,
0.330820769071579,
0.07254910469055176,
-0.05016576126217842,
0.01812729984521866,
-0.7052510976791382,
-0.3951493799686432,
0.10539648681879044,
-0.03944722190499306,
0.19809548556804657,
-0.03665395453572273,
0.9310212731361389,
0.24573354423046112,
0.21362635493278503,
-0.4006105661392212,
0.14304226636886597,
0.1820438653230667,
0.00543411448597908,
0.00004448353502084501,
0.17758041620254517,
-0.5332332253456116,
0.10168824344873428,
-0.6039279103279114,
-0.04207348823547363,
0.9101009964942932,
0.15868334472179413,
-0.37234845757484436,
-0.17745713889598846,
0.22704555094242096,
0.2841741442680359,
0.11821461468935013,
-0.222584068775177,
-0.19597087800502777,
-0.46839815378189087,
-0.10619259625673294,
-0.33148178458213806,
0.5104103684425354,
-0.037907641381025314,
-0.15988831222057343,
-0.35103076696395874,
0.2971617579460144,
0.5804950594902039,
-0.4011423885822296,
0.798170804977417,
0.07368506491184235,
-0.1678258776664734,
-0.3961721956729889,
0.178167462348938,
-0.16279742121696472,
-0.1766856610774994,
-0.09049464762210846,
0.4737529158592224,
0.9692805409431458,
-0.06182384863495827,
0.022481342777609825,
-0.36044418811798096,
0.05553313344717026,
0.37239450216293335,
-0.1537291407585144,
0.008918846026062965,
-0.18011172115802765,
-0.23971182107925415,
-0.9414939880371094,
0.35349154472351074,
0.0004890917334705591,
-0.04163409024477005,
-0.22086124122142792,
-0.0708204060792923,
-0.5044238567352295,
-0.08101743459701538,
-0.15242336690425873,
-0.869687020778656,
-0.42631012201309204,
-0.11635731160640717
] |
Candida albicans in the immunocompetent host is a benign member of the human microbiota. Though, when host physiology is disrupted, this commensal-host interaction can degenerate and lead to an opportunistic infection. Relatively little is known regarding the dynamics of C. albicans colonization and pathogenesis. We developed a C. albicans cell surface protein microarray to profile the immunoglobulin G response during commensal colonization and candidemia. The antibody response from the sera of patients with candidemia and our negative control groups indicate that the immunocompetent host exists in permanent host-pathogen interplay with commensal C. albicans. This report also identifies cell surface antigens that are specific to different phases (i.e. acute, early and mid convalescence) of candidemia. We identified a set of thirteen cell surface antigens capable of distinguishing acute candidemia from healthy individuals and uninfected hospital patients with commensal colonization. Interestingly, a large proportion of these cell surface antigens are involved in either oxidative stress or drug resistance. In addition, we identified 33 antigenic proteins that are enriched in convalescent sera of the candidemia patients. Intriguingly, we found within this subset an increase in antigens associated with heme-associated iron acquisition. These findings have important implications for the mechanisms of C. albicans colonization as well as the development of systemic infection. | [
-0.023542866110801697,
0.022520432248711586,
-0.010921881534159184,
0.014400100335478783,
-0.0032002634834498167,
-0.005027960520237684,
0.01039181463420391,
-0.004218074027448893,
-0.014597240835428238,
0.0061535220593214035,
-0.00707310950383544,
0.020576074719429016,
-0.0011224618647247553,
0.033160459250211716,
-0.006606912240386009,
0.00126559566706419,
-0.009778046980500221,
-0.004866437520831823,
0.006553905550390482,
-0.000838826410472393,
0.016716089099645615,
0.0025593263562768698,
0.009830881841480732,
0.022559303790330887,
-0.0044982279650866985,
-0.0051858434453606606,
-0.005894802510738373,
-0.0025393336545675993,
-0.032403022050857544,
-0.009498078376054764,
0.0038211485370993614,
-0.005711512640118599,
0.025820743292570114,
-0.021210316568613052,
-0.00494004599750042,
-0.0003843418089672923,
-0.00003184870001859963,
0.0285214614123106,
0.018868757411837578,
-0.003819168545305729,
0.022266721352934837,
-0.004892115481197834,
0.0023485803976655006,
0.015344792045652866,
-0.00432810140773654,
0.003944842144846916,
0.0010047736577689648,
0.03176078200340271,
-0.00922582857310772,
0.003286597318947315,
-0.005694007501006126,
-0.014389093965291977,
-0.009288686327636242,
-0.01819254644215107,
-0.00613362155854702,
0.002255474217236042,
0.017830995842814445,
-0.022465666756033897,
0.011818986386060715,
0.025105223059654236,
-0.005345501471310854,
-0.02412310615181923,
0.014947467483580112,
-0.038239870220422745,
-0.0037002116441726685,
-0.06738067418336868,
0.016984574496746063,
-0.011891951784491539,
-0.0016589078586548567,
-0.0027157803997397423,
-0.0036833102349191904,
0.006676094606518745,
-0.010391592048108578,
0.00672698300331831,
-0.005877116695046425,
-0.024503543972969055,
-0.011925553902983665,
0.011915910057723522,
0.01467741746455431,
0.028514131903648376,
-0.01949382945895195,
0.006247411482036114,
0.01604737713932991,
0.01416695024818182,
0.0009554915595799685,
-0.0056884996592998505,
-0.015573784708976746,
-0.002973811700940132,
0.001267588697373867,
-0.01994216814637184,
0.016453072428703308,
-0.01674429327249527,
-0.023843688890337944,
-0.011914180591702461,
0.0025966009125113487,
-0.01987530291080475,
-0.011424342170357704,
-0.004590224474668503,
0.003587794955819845,
-0.03878673166036606,
-0.012730131857097149,
-0.013403741642832756,
0.020289989188313484,
0.00246813939884305,
-0.007237582001835108,
0.003826475702226162,
0.00760385999456048,
0.0032858240883797407,
0.023008979856967926,
0.01589503139257431,
0.0007831489201635122,
-0.018675237894058228,
0.02237936109304428,
0.03874713554978371,
0.016206789761781693,
0.022684244439005852,
0.007281789090484381,
-0.018989233300089836,
0.01749696582555771,
-0.015683574602007866,
-0.005870445631444454,
0.003221719991415739,
-0.00310977129265666,
-0.023274026811122894,
0.004702066071331501,
0.009778909385204315,
-0.0004131533205509186,
0.001136947888880968,
0.04238518327474594,
0.006032133009284735,
-0.004780058283358812,
-0.002286802977323532,
-0.01468681637197733,
0.010631266050040722,
0.008618880063295364,
-0.004898785147815943,
-0.02782646380364895,
0.016912885010242462,
-0.011146990582346916,
-0.02012612856924534,
-0.02529234252870083,
0.005174873396754265,
-0.005941298790276051,
0.010527883656322956,
0.004881995730102062,
0.0070001184940338135,
-0.012179795652627945,
0.007484898902475834,
0.0019137617200613022,
-0.0196718517690897,
0.014379183761775494,
-0.016421828418970108,
0.008548172190785408,
-0.0020818598568439484,
0.029316496104002,
0.009349222294986248,
0.00044662458822131157,
-0.02173173986375332,
-0.009228933602571487,
0.00459660729393363,
0.002466881647706032,
-0.019651956856250763,
0.01658111810684204,
0.010008365847170353,
0.02493353560566902,
0.013821715489029884,
0.01457764208316803,
0.00281336042098701,
-0.011566979810595512,
0.004685056395828724,
-0.006692216731607914,
0.016697991639375687,
-0.011571227572858334,
0.0071245827712118626,
0.007290062494575977,
-0.0005877860821783543,
0.018473893404006958,
0.006920741870999336,
-0.009952803142368793,
0.06718108057975769,
-0.025335945188999176,
-0.01009407825767994,
-0.0016741459257900715,
0.0031357593834400177,
0.012688787654042244,
0.008548803627490997,
0.01007731631398201,
0.006847582757472992,
-0.013057856820523739,
-0.016725849360227585,
-0.013861140236258507,
-0.024788275361061096,
-0.02242930606007576,
-0.0016971053555607796,
0.012259422801434994,
0.0031621046364307404,
0.0087441960349679,
0.009126253426074982,
0.01896088570356369,
-0.02131796069443226,
-0.006411667447537184,
0.007001467514783144,
0.026426877826452255,
-0.012411913834512234,
-0.01385422982275486,
-0.001569500658661127,
-0.004974729847162962,
0.015644751489162445,
-0.017954453825950623,
-0.019412968307733536,
0.018081024289131165,
0.015552578493952751,
-0.017748413607478142,
-0.021897373721003532,
-0.00942603312432766,
0.00016476213932037354,
0.01078970730304718,
-0.01134810782968998,
-0.007024894002825022,
-0.010528402402997017,
-0.006640822626650333,
0.011539272964000702,
-0.008347610011696815,
-0.0015087826177477837,
-0.002287242328748107,
-0.006654726807028055,
0.004850182682275772,
0.011308358982205391,
-0.0069862250238657,
0.008895492181181908,
-0.007980420254170895,
-0.009457390755414963,
-0.00956485141068697,
-0.021059256047010422,
-0.008366106078028679,
0.024114491418004036,
0.013696236535906792,
-0.019912701100111008,
0.004686184227466583,
-0.00974228698760271,
0.0014278329908847809,
0.013909032568335533,
0.027423884719610214,
-0.0034617430064827204,
-0.01502332091331482,
0.013280227780342102,
0.011137737892568111,
0.003007717663422227,
0.011966457590460777,
-0.01101619191467762,
0.0077801113948225975,
-0.010546019300818443,
-0.017951518297195435,
-0.02545350417494774,
0.003145163645967841,
-0.007576623931527138,
-0.0012684513349086046,
-0.010221301577985287,
0.024880750104784966,
-0.007551484741270542,
0.0018822465790435672,
0.003022903110831976,
-0.005999321583658457,
0.0028320197016000748,
0.01687725819647312,
0.013297390192747116,
0.0007441586349159479,
0.01918015442788601,
0.0037128771655261517,
-0.023510020226240158,
0.008315224200487137,
-0.005803321488201618,
0.0016697795363143086,
-0.08180388808250427,
-0.01969844102859497,
-0.0072535318322479725,
-0.009435751475393772,
0.0030319488141685724,
0.023043014109134674,
-0.01748204231262207,
0.001078855013474822,
-0.003644688753411174,
0.05037113279104233,
0.026680834591388702,
0.015825180336833,
-0.007450875826179981,
-0.004514971747994423,
0.019154734909534454,
-0.003981406334787607,
0.00012572589912451804,
-0.01187435444444418,
-0.018987923860549927,
-0.020565424114465714,
0.03217592090368271,
0.002276357728987932,
0.0017925312276929617,
-0.011744721792638302,
0.0005251015536487103,
0.00951564870774746,
-0.020153449848294258,
0.003494219621643424,
0.02940584160387516,
0.008718833327293396,
-0.006686462089419365,
-0.013433201238512993,
0.024189699441194534,
0.02631298452615738,
0.01041826419532299,
-0.019632047042250633,
0.007760952226817608,
-0.02757119946181774,
-0.02632908709347248,
0.022606872022151947,
-0.015753712505102158,
0.02094779722392559,
0.03241530805826187,
-0.007714880630373955,
0.03262967988848686,
-0.0009603834478184581,
0.03202975541353226,
0.006350890267640352,
0.014680499210953712,
0.0002150316722691059,
0.012973173521459103,
-0.0003005261532962322,
0.025545533746480942,
0.015100845135748386,
-0.011033672839403152,
0.009904317557811737,
-0.01932857558131218,
0.03229185938835144,
-0.0097799738869071,
-0.005420864559710026,
0.011404372751712799,
-0.0018629166297614574,
0.0162983238697052,
0.009135912172496319,
-0.0010102465748786926,
0.01570795848965645,
0.014687111601233482,
-0.011273033916950226,
0.005504387430846691,
0.0207301564514637,
-0.01798360049724579,
-0.018558893352746964,
0.031009458005428314,
-0.006814754568040371,
0.010024982504546642,
-0.0020306033547967672,
-0.010616632178425789,
-0.01111680082976818,
0.0016974490135908127,
-0.0057564303278923035,
0.0012319190427660942,
0.0018759826198220253,
0.020303845405578613,
-0.006467031314969063,
-0.008177777752280235,
0.007003540173172951,
0.0026442173402756453,
0.03571638464927673,
0.004392406903207302,
-0.013970037922263145,
-0.010130018927156925,
-0.0042618149891495705,
-0.03479400649666786,
0.0071502914652228355,
0.02733573690056801,
0.0026369334664195776,
-0.005521181970834732,
0.006490933708846569,
-0.01671867072582245,
0.007536897901445627,
-0.0050492556765675545,
-0.018448233604431152,
-0.022065144032239914,
-0.005783426109701395,
-0.0026914163026958704,
0.010557496920228004,
0.004904141183942556,
0.00005457224324345589,
-0.017705388367176056,
-0.00871173944324255,
0.017458271235227585,
0.019909078255295753,
-0.006981848739087582,
-0.018185840919613838,
0.015254486352205276,
0.03707301616668701,
-0.00371278147213161,
-0.004892605822533369,
0.07207813858985901,
0.011361662298440933,
-0.009321944788098335,
0.002907529706135392,
0.008551986888051033,
-0.01900351420044899,
0.01895798370242119,
-0.008247178979218006,
-0.00926705077290535,
0.012394262477755547,
0.012668158859014511,
-0.013721974566578865,
-0.00625818595290184,
0.027277451008558273,
-0.01920469105243683,
-0.014240549877285957,
-0.025999976322054863,
-0.03987852483987808,
0.011192325502634048,
-0.002710275584831834,
-0.01005901861935854,
-0.008325643837451935,
0.008153175935149193,
0.010308006778359413,
-0.007887054234743118,
-0.03566431999206543,
0.030470198020339012,
-0.015756040811538696,
-0.02959001064300537,
0.0020464248955249786,
0.008329751901328564,
-0.016818854957818985,
-0.00905490294098854,
0.0073753222823143005,
0.00445130467414856,
0.007538212463259697,
0.020160984247922897,
0.024411529302597046,
0.016434703022241592,
-0.011671394109725952,
0.006749971769750118,
-0.00978991761803627,
0.015290536917746067,
0.010515304282307625,
-0.007851466536521912,
-0.007512512616813183,
-0.0038036126643419266,
-0.0008683924097567797,
-0.00797299388796091,
-0.01660113036632538,
-0.00573723716661334,
-0.006292951758950949,
0.005537644028663635,
0.019466284662485123,
0.0012678549392148852,
0.0012643482768908143,
0.010937412269413471,
-0.01092471368610859,
0.007177210878580809,
0.004001806024461985,
-0.03894612193107605,
-0.005373003892600536,
0.028729133307933807,
-0.0044677481055259705,
-0.0046598538756370544,
0.0039372676983475685,
-0.0024096211418509483,
0.009755710139870644,
-0.012571332044899464,
0.014388978481292725,
-0.009114362299442291,
-0.021628323942422867,
-0.009347831830382347,
0.0003900867886841297,
-0.01240657176822424,
-0.00592912919819355,
0.0023104045540094376,
-0.011946507729589939,
-0.0014567277394235134,
0.003966592717915773,
0.009076803922653198,
0.003759875427931547,
0.017665673047304153,
0.013050734996795654,
-0.01303837075829506,
0.01877228170633316,
-0.012961719185113907,
-0.07464410364627838,
0.013273393735289574,
-0.014134138822555542,
-0.00332050584256649,
-0.00978940911591053,
-0.005958219058811665,
-0.02282819151878357,
0.006281151436269283,
-0.010973144322633743,
-0.008663528598845005,
-0.043072208762168884,
-0.014009149745106697,
0.013669190928339958,
0.013852618634700775,
0.010082163847982883,
0.022081535309553146,
-0.018495548516511917,
-0.010821787640452385,
-0.022909777238965034,
0.02542809769511223,
0.0109394621104002,
-0.005686861928552389,
-0.03007931262254715,
0.015968767926096916,
0.005907644983381033,
-0.08091390132904053,
-0.019305288791656494,
-0.004037967883050442,
0.008786365389823914,
-0.002798807341605425,
-0.013657018542289734,
-0.01754213497042656,
-0.0013607072178274393,
0.0000975137809291482,
-0.016465963795781136,
-0.005361123941838741,
0.009728421457111835,
-0.018223315477371216,
-0.016232682392001152,
0.0005960920825600624,
-0.0036777914501726627,
0.017944013699889183,
0.0001354762353003025,
0.01452045701444149,
0.0002620355226099491,
-0.031385064125061035,
0.024957139045000076,
-0.010900082066655159,
0.005794440861791372,
-0.0019134166650474072,
-0.010993601754307747,
0.003931446932256222,
0.012975262477993965,
-0.01573493890464306,
-0.004085843451321125,
0.00005627621430903673,
0.0052376254461705685,
-0.03266693651676178,
-0.005296672694385052,
-0.023866139352321625,
-0.016171302646398544,
0.01037562359124422,
-0.010388237424194813,
0.0305112786591053,
0.007730134297162294,
-0.003001665696501732,
0.00488667469471693,
0.010158678516745567,
0.015227159485220909,
-0.011220480315387249,
0.0003398092230781913,
0.004726820159703493,
-0.005376768298447132,
0.018913131207227707,
0.014979923143982887,
0.0062871696427464485,
0.005498944781720638,
0.014754456467926502,
0.013369809836149216,
0.00889441929757595,
0.004492463078349829,
-0.0004824679344892502,
0.007684584241360426,
0.01539340615272522,
0.013106631115078926,
-0.00007325084879994392,
0.016901949420571327,
0.006590609904378653,
0.07247176766395569,
-0.0012077100109308958,
0.005457224324345589,
-0.005014874041080475,
0.011099639348685741,
0.0041890935972332954,
-0.026030408218503,
0.020902320742607117,
-0.01092512160539627,
-0.013051246292889118,
0.007173506543040276,
-0.005094623193144798,
0.013775627128779888,
0.009671883657574654,
0.011738639324903488,
-0.009709076955914497,
-0.012058833613991737,
-0.012011462822556496,
0.013943374156951904,
-0.01105570700019598,
-0.0004902962245978415,
-0.024724189192056656,
-0.02377953752875328,
-0.006980956066399813,
0.03541705384850502,
-0.000963983591645956,
0.0002662247861735523,
0.004727979190647602,
-0.023040838539600372,
0.01826459914445877,
-0.012084458954632282,
0.012760263867676258,
0.002298966748639941,
-0.018598655238747597,
-0.008652426302433014,
-0.005094682332128286,
0.010837231762707233,
0.006480871699750423,
-0.009603630751371384,
-0.03372415527701378,
0.029318878427147865,
-0.010826494544744492,
-0.002414170652627945,
-0.019785625860095024,
-0.003732110373675823,
-0.036017026752233505,
0.010041870176792145,
0.012167667970061302,
0.008768448606133461,
0.028703924268484116,
-0.008829379454255104,
0.002827547024935484,
-0.012336105108261108,
0.015878789126873016,
0.004625909961760044,
-0.020178545266389847,
-0.014971837401390076,
0.012106314301490784,
-0.0033580102026462555,
-0.008093589916825294,
0.0031316522508859634,
-0.010708835907280445,
0.009414336644113064,
-0.013134842738509178,
0.004880085121840239,
0.007358028553426266,
0.002908549504354596,
-0.015025520697236061,
-0.009465856477618217,
0.01239101029932499,
-0.0007982936222106218,
-0.0030528255738317966,
0.004665054380893707,
-0.005238687619566917,
0.021038658916950226,
-0.02025097981095314,
0.007459255401045084,
0.007515006698668003,
0.016141779720783234,
0.01297268457710743,
-0.0029690435621887445,
0.0017857104539871216,
0.0005950345657765865,
-0.005407753400504589,
-0.0024139261804521084,
0.0003440403379499912,
-0.013073055073618889,
0.019274281337857246,
-0.005448733456432819,
0.0025129267014563084,
0.02545379474759102,
0.01053486205637455,
0.002258031163364649,
0.00016904855147004128,
0.004401820711791515,
0.03447723761200905,
-0.012347615323960781,
0.004861076828092337,
-0.006573967635631561,
-0.00808764062821865,
-0.0010101692751049995,
0.007042297627776861,
0.0049748048186302185,
-0.02288312278687954,
0.0027481778524816036,
-0.003497685771435499,
0.0006186575628817081,
-0.00732826255261898,
0.021978076547384262,
0.023037122562527657,
0.0051318989135324955,
-0.028236761689186096,
-0.0061842151917517185,
-0.003755369922146201,
-0.005309213884174824,
0.003383803181350231,
-0.0012130164541304111,
-0.0020565595477819443,
-0.02360454946756363,
-0.009424435906112194,
-0.013388977386057377,
0.005914583336561918,
-0.001675270963460207,
0.014559634029865265,
0.03977223485708237,
-0.017349228262901306,
-0.008479153737425804,
0.013725969940423965,
0.0031731820199638605,
-0.002464761259034276,
0.010059373453259468,
-0.004141910467296839,
0.023446496576070786,
-0.003434170037508011,
0.001943835522979498,
-0.0322146974503994,
0.014783427119255066,
0.036782845854759216,
-0.0017589223571121693,
0.01926877349615097,
0.015784423798322678,
-0.00011298543540760875,
0.005277110263705254,
0.00947179738432169,
0.007609860505908728,
-0.004084062296897173,
0.001451445510610938,
0.008894833736121655,
0.012183609418570995,
0.012853404507040977,
-0.0009264149703085423,
0.01275305263698101,
-0.02251889742910862,
-0.0076905894093215466,
-0.014076829887926579,
0.006378741469234228,
0.0026206672191619873,
-0.006904091686010361,
-0.0008071701158769429,
-0.00671033188700676,
0.029720108956098557,
-0.025869250297546387,
-0.0207434743642807,
0.01163566391915083,
-0.003115786472335458,
0.036631472408771515,
-0.012319349683821201,
0.02495443820953369,
0.0005073156207799911,
0.002110712695866823,
0.01030676532536745,
-0.0015293261967599392,
-0.020728491246700287,
0.0007126479176804423,
-0.026046868413686752,
-0.004676295910030603,
-0.009859256446361542,
0.010579944588243961,
-0.03285345807671547,
-0.0012157181045040488,
-0.00418079225346446,
-0.016132593154907227,
0.013729286380112171,
-0.00426725298166275,
0.01744018867611885,
-0.0025790666695684195,
-0.0056007420644164085,
0.005773942917585373,
0.005370405502617359,
-0.010670132003724575,
0.008799280039966106,
-0.013462642207741737,
-0.011506542563438416,
0.008712253533303738,
0.0037098918110132217,
-0.02299538068473339,
-0.011026062071323395,
0.019175592809915543,
-0.005032217595726252,
0.005879218690097332,
0.02107846736907959,
0.004682718776166439
] | [
-0.16980613768100739,
0.09334564208984375,
0.10109075158834457,
-0.14841599762439728,
0.24070999026298523,
-0.1397097408771515,
0.4480089247226715,
0.4702770411968231,
-0.06559944152832031,
-0.4113669991493225,
0.08679406344890594,
-0.2832277715206146,
-1.0447567701339722,
0.6042355895042419,
-0.0970856249332428,
0.7141628265380859,
0.30676135420799255,
0.6895014643669128,
-0.30566099286079407,
0.03857024013996124,
-0.35267043113708496,
-0.42982780933380127,
0.6005532145500183,
-0.570676326751709,
0.027006329968571663,
-0.5461934804916382,
0.6475709676742554,
0.7208343148231506,
0.15457355976104736,
-0.4927949607372284,
-0.04602670297026634,
0.5436891913414001,
0.33344173431396484,
0.23672565817832947,
-0.11038193851709366,
-0.016788534820079803,
-0.07898421585559845,
-0.05150631070137024,
0.16073700785636902,
-0.2977167069911957,
-0.2741682827472687,
0.10391020029783249,
-0.1820652037858963,
0.5820028185844421,
-0.28258511424064636,
-0.09402655810117722,
-1.3799970149993896,
0.919026792049408,
-0.5999133586883545,
-0.09343042224645615,
0.09902603179216385,
-0.2073356807231903,
0.45495763421058655,
0.327475905418396,
-0.101429782807827,
0.18950095772743225,
-0.7280806303024292,
-0.22801588475704193,
0.13708527386188507,
-0.4772268235683441,
-0.06599997729063034,
-0.2715727984905243,
-0.10380187630653381,
-0.0338427871465683,
0.24458692967891693,
0.5178491473197937,
-0.06227261573076248,
-0.2764059603214264,
-0.2582334578037262,
-0.1016290932893753,
-0.27315855026245117,
-0.7698149085044861,
-0.36186498403549194,
0.47243210673332214,
-0.21737252175807953,
-0.14168816804885864,
-0.02560768462717533,
-0.3318672776222229,
0.0895664170384407,
0.12317325919866562,
0.02191797085106373,
-0.21801143884658813,
0.14809449017047882,
0.023984747007489204,
0.4235997796058655,
0.008640365675091743,
-0.2506459057331085,
0.7246702909469604,
-0.43382787704467773,
0.1061401218175888,
0.09368015825748444,
0.06811375916004181,
0.5226854085922241,
0.12135205417871475,
0.22173230350017548,
0.13464254140853882,
0.2356446087360382,
-0.11281222850084305,
0.35519492626190186,
0.2902151346206665,
-0.7761591672897339,
0.34934306144714355,
-0.36386993527412415,
-0.02542348951101303,
-0.6741226315498352,
0.19567641615867615,
-0.18011000752449036,
-0.4771762192249298,
-0.3823366165161133,
0.4145774245262146,
-0.34968671202659607,
0.4254501760005951,
0.012785384431481361,
-0.2632497549057007,
-0.36533451080322266,
0.3302539587020874,
0.11241418868303299,
-0.6198587417602539,
-0.27529099583625793,
0.22176925837993622,
-0.10607805848121643,
0.8673714399337769,
-0.2311379313468933,
-0.14925462007522583,
0.04748329520225525,
-0.08353035151958466,
-0.15118145942687988,
-0.35208550095558167,
-0.2076912373304367,
0.7734315395355225,
0.6413682699203491,
0.4553760886192322,
-0.24208609759807587,
-0.14434956014156342,
0.008226077072322369,
-0.35528433322906494,
-0.1735151708126068,
0.362175315618515,
0.8581867814064026,
0.005758924409747124,
-0.52811199426651,
-0.39507749676704407,
-0.626790463924408,
0.5059253573417664,
0.16771367192268372,
-0.4864106774330139,
-0.22630028426647186,
0.03694291412830353,
-0.36973991990089417,
-0.4030528962612152,
0.0519123300909996,
-0.21104112267494202,
-0.43157491087913513,
-0.008580480702221394,
-0.4512676000595093,
0.19850049912929535,
-0.21978530287742615,
-0.12076297402381897,
-0.020933212712407112,
0.48808109760284424,
-0.07793676853179932,
-0.22032062709331512,
-0.34212711453437805,
-0.005536437500268221,
0.747796356678009,
0.15631063282489777,
0.05377912148833275,
0.7517261505126953,
0.3486270308494568,
-0.08332868665456772,
-0.08405977487564087,
-0.5697970986366272,
0.20087365806102753,
-0.6245706677436829,
-0.08414126932621002,
0.14450626075267792,
0.2993831932544708,
-0.21060070395469666,
0.5195816159248352,
-0.013431907631456852,
-0.7224226593971252,
0.1851079910993576,
-0.024276450276374817,
0.18066337704658508,
-0.3698565661907196,
0.21056988835334778,
-0.0026517075020819902,
0.05023585259914398,
0.14914573729038239,
-0.09814680367708206,
-0.47955915331840515,
-0.32480746507644653,
0.40867510437965393,
-0.9102576971054077,
1.1677875518798828,
-0.027407938614487648,
-0.6387198567390442,
0.8013851642608643,
0.19897644221782684,
-0.43383845686912537,
-0.3486963212490082,
0.03498664125800133,
0.3626162111759186,
-0.19561536610126495,
-0.9162911772727966,
0.23159100115299225,
0.04887526482343674,
-0.04832858219742775,
0.6662068367004395,
0.41031110286712646,
0.335847944021225,
-0.19785237312316895,
0.1972513049840927,
-0.2609570622444153,
0.2540914714336395,
-0.6329116225242615,
-0.3290019929409027,
0.09995909035205841,
-0.20409436523914337,
0.1548348367214203,
0.5711835622787476,
-0.7343918085098267,
0.3807911276817322,
0.7326899170875549,
-0.14403897523880005,
0.4716660976409912,
0.5136765241622925,
0.23683509230613708,
1.204643964767456,
-0.4380529224872589,
0.7526917457580566,
0.00040252000326290727,
0.8699967861175537,
-0.7230179905891418,
-0.5330115556716919,
0.45060300827026367,
0.38795599341392517,
-0.04134705290198326,
0.27050071954727173,
-0.04152338206768036,
-0.16727517545223236,
0.21248281002044678,
-0.7387049794197083,
0.2425045520067215,
-0.45161351561546326,
-0.35217568278312683,
-0.05424908548593521,
0.06914070248603821,
-0.8599156141281128,
-0.18851447105407715,
0.6215300559997559,
0.5255175232887268,
0.5032680034637451,
-0.5101203322410583,
0.4855245351791382,
0.022623639553785324,
-0.3300442099571228,
0.016421690583229065,
0.6675706505775452,
-0.03142030909657478,
-0.763349175453186,
0.29050830006599426,
0.3725024163722992,
0.8912152051925659,
-0.3232690393924713,
0.0332866869866848,
0.14342574775218964,
-0.2332833707332611,
-0.0441301204264164,
0.8315656781196594,
0.770228922367096,
-0.003346559125930071,
-0.9299555420875549,
0.012461388483643532,
0.32782602310180664,
-0.10599477589130402,
-0.3645465672016144,
0.6350123286247253,
-0.2376215010881424,
-0.10570523142814636,
-0.37068575620651245,
0.9482273459434509,
0.05409770458936691,
-0.3183589577674866,
-0.24797943234443665,
-0.7693440318107605,
0.08128724992275238,
-0.4571131765842438,
-0.6887590289115906,
-0.1487918198108673,
-0.6231215596199036,
0.43108466267585754,
-0.7366511821746826,
0.12201523780822754,
-0.3062746822834015,
0.015309961512684822,
-0.3887900412082672,
0.013451867736876011,
0.7371450066566467,
-0.24205343425273895,
-0.0901070311665535,
0.13337011635303497,
-0.11269568651914597,
0.0965670645236969,
-0.017718400806188583,
0.16062752902507782,
-0.15764650702476501,
0.17068815231323242,
-5.642061233520508,
0.20569710433483124,
0.07955024391412735,
0.3910057246685028,
0.10231925547122955,
-0.3133465051651001,
0.6955761909484863,
-0.2428414672613144,
0.09429451823234558,
0.13399508595466614,
0.5458709597587585,
0.2230079472064972,
-0.09747862070798874,
0.3237915635108948,
0.07439689338207245,
-0.10781648010015488,
0.0914086103439331,
-0.2880691587924957,
-0.13453340530395508,
0.05801869183778763,
-0.022607235237956047,
0.24376484751701355,
0.235907644033432,
0.7953095436096191,
0.12367063760757446,
0.21173492074012756,
-0.7874507308006287,
0.5908566117286682,
0.013522137887775898,
0.043580640107393265,
-0.11533194780349731,
-0.9494698643684387,
0.03627645596861839,
-0.5822638273239136,
0.4666024148464203,
0.20649929344654083,
-0.3538751006126404,
-0.2032613307237625,
-0.28454047441482544,
-0.02394593320786953,
0.1856248527765274,
0.2560257315635681,
-0.5935559868812561,
0.11661357432603836,
0.15063457190990448,
0.1651153415441513,
-0.08686899393796921,
0.2542271614074707,
-0.2359268218278885,
0.9462165236473083,
0.44356122612953186,
-0.004898557905107737,
0.33585646748542786,
0.5561097860336304,
0.5126239061355591,
0.058335497975349426,
0.4350890815258026,
-0.07364997267723083,
-0.2691086530685425,
-0.2483471930027008,
-0.16838063299655914,
-0.10917683690786362,
-0.5638949871063232,
0.01314545888453722,
0.1786896288394928,
0.23232193291187286,
-0.7406050562858582,
0.35193386673927307,
0.713424563407898,
-0.6751601696014404,
-0.6639602184295654,
0.11824262142181396,
0.3521747291088104,
-0.9904229640960693,
0.5868134498596191,
-0.10902450233697891,
-0.21284307539463043,
-0.041595906019210815,
0.39981234073638916,
-0.062042366713285446,
-0.10780486464500427,
0.050320304930210114,
-0.054878320544958115,
-0.5742409229278564,
0.009843581356108189,
-1.081221342086792,
0.054469168186187744,
-0.006534455809742212,
-0.6218393445014954,
0.021808737888932228,
0.36060163378715515,
-0.2619224786758423,
0.4486657679080963,
0.38432472944259644,
0.31530970335006714,
0.7886629104614258,
0.27776122093200684,
0.4908682107925415,
0.40737539529800415,
-0.11816930025815964,
1.3059617280960083,
-0.033702339977025986,
-0.3479432463645935,
-0.5943986773490906,
0.5201262831687927,
0.1783195585012436,
-0.7643800377845764,
0.2659440338611603,
0.3734712302684784,
-0.7715323567390442,
0.4175824522972107,
0.2578698396682739,
-0.3057447075843811,
-0.4000589847564697,
0.7616381049156189,
-0.189109206199646,
-0.03577275201678276,
0.34007954597473145,
1.0287367105484009,
-0.5505401492118835,
0.38997095823287964,
0.6086523532867432,
-0.4680587947368622,
0.2431327998638153,
-0.2753855288028717,
0.4830988347530365,
0.13218052685260773,
0.5585156083106995,
-0.6720918416976929,
-0.24227073788642883,
0.16893112659454346,
0.09553998708724976,
-0.7099502086639404,
-0.2834343910217285,
0.5427458882331848,
0.031912900507450104,
-0.23366740345954895,
0.05466422811150551,
-0.3303678333759308,
-0.3999949097633362,
-0.08770472556352615,
-0.38399726152420044,
-0.09789915382862091,
0.07395389676094055,
-0.17236892879009247,
-0.09295772761106491,
0.44883161783218384,
-0.18847806751728058,
0.013870665803551674,
-0.3026387393474579,
0.4070237874984741,
0.19664020836353302,
0.02427736483514309,
0.26088857650756836,
-0.41731128096580505,
-0.10408756136894226,
0.6291245222091675,
0.2370266318321228,
0.0922742411494255,
-0.669672966003418,
0.3172552287578583,
-0.2686670422554016,
-1.006116509437561,
0.019187701866030693,
-0.1456337720155716,
-0.1294892579317093,
0.521528959274292,
-0.2409348338842392,
0.18087229132652283,
0.3193400800228119,
-0.10786004364490509,
0.07848450541496277,
-0.5884089469909668,
-0.2284293919801712,
-0.04058392718434334,
-0.6187544465065002,
-0.6332690119743347,
0.2516538202762604,
-0.0964423194527626,
0.2752222716808319,
-0.09562360495328903,
-0.7160255312919617,
-0.21343182027339935,
-0.3355398178100586,
0.4968373775482178,
-0.5008267760276794,
0.43418562412261963,
-0.5410759449005127,
-0.46006324887275696,
-0.9804846048355103,
0.43621280789375305,
0.32963651418685913,
0.4977259933948517,
-0.024064412340521812,
0.09657049924135208,
-0.3037926256656647,
-0.1638209968805313,
0.7802024483680725,
-0.2420218288898468,
-0.6406735777854919,
0.12630227208137512,
0.45349597930908203,
-0.9479718208312988,
0.7090502977371216,
0.3750666379928589,
-0.17941488325595856,
0.22314979135990143,
-0.40476012229919434,
0.38637492060661316,
0.08832588791847229,
-0.4166409373283386,
0.031069930642843246,
-0.14238597452640533,
0.5274735689163208,
-0.14682543277740479,
-0.01260474231094122,
-0.33851489424705505,
-0.25671178102493286,
0.09431326389312744,
0.8548636436462402,
0.26495715975761414,
0.3484621047973633,
0.07039406150579453,
0.017768526449799538,
-0.0017143752193078399,
0.6378453969955444,
0.7191859483718872,
-0.6134836077690125,
-0.05320562794804573,
-0.04661533609032631,
0.3622719943523407,
-0.36605703830718994,
0.7541947364807129,
0.04842004552483559,
-0.5783455967903137,
-0.222462460398674,
0.2590988576412201,
-0.01923738233745098,
-0.19982409477233887,
0.7341949343681335,
0.2883182466030121,
-0.025552576407790184,
-0.8421019315719604,
-0.31659847497940063,
0.30714452266693115,
0.6826968193054199,
0.19073359668254852,
-0.24711914360523224,
-0.7554242610931396,
-0.20475588738918304,
0.23097075521945953,
0.025505458936095238,
0.22719557583332062,
0.4799642860889435,
0.6491965651512146,
-0.672648549079895,
-0.31206390261650085,
-0.23153774440288544,
-0.14079321920871735,
-0.2601756155490875,
0.16811306774616241,
0.06251963973045349,
-0.02296721190214157,
0.36258363723754883,
-0.3711163103580475,
-0.6337069272994995,
-0.31587281823158264,
-0.44435617327690125,
0.38458889722824097,
-0.2272990196943283,
-0.00008246752986451611,
-0.17366982996463776,
1.1595031023025513,
0.32510772347450256,
-0.015219027176499367,
0.35246479511260986,
-0.5535896420478821,
-0.30107417702674866,
-0.23112022876739502,
0.22853009402751923,
-0.5438226461410522,
-0.4307863116264343,
-0.12306447327136993,
-0.24785487353801727,
0.08503042161464691,
-0.7951388955116272,
0.07418404519557953,
-0.12249600887298584,
-0.12237795442342758,
-0.4685341417789459,
-0.4148692488670349,
0.09784850478172302,
-0.13931059837341309,
-0.7299633026123047,
0.1146191656589508,
-0.008597665466368198,
-0.32258009910583496,
-0.17965994775295258,
-0.15174080431461334,
-0.35233065485954285,
-0.8202337622642517,
0.2647102177143097,
0.9017807841300964,
-0.21474367380142212,
0.4647657871246338,
0.30111587047576904,
0.021600613370537758,
-0.20238639414310455,
-0.3731206953525543,
-0.3965704143047333,
-0.14816135168075562,
0.13881200551986694,
0.23993651568889618,
0.11605226248502731,
-0.3758983910083771,
0.38752591609954834,
-0.3869204819202423,
-0.7092081904411316,
0.2628728151321411,
0.5307053923606873,
0.3501395881175995,
0.43991273641586304,
0.31420478224754333,
0.019184913486242294,
-0.13838346302509308,
0.018309535458683968,
0.1841064840555191,
0.2791988253593445,
-0.07886114716529846,
0.4421606659889221,
0.6190981268882751,
-0.08378555625677109,
-0.2860952317714691,
0.41544651985168457,
0.3432331383228302,
0.26054590940475464,
-0.030145352706313133,
-0.5707231760025024,
-0.31388184428215027,
0.5226945877075195,
0.735702633857727,
0.030458753928542137,
-0.16982392966747284,
-0.22943115234375,
0.09227050840854645,
0.35408255457878113,
0.07525069266557693,
0.10886113345623016,
0.1855047643184662,
0.19921433925628662,
0.7282236814498901,
0.04540538415312767,
-0.33702710270881653,
0.14983615279197693,
-0.8298896551132202,
0.13349471986293793,
0.6741176843643188,
-0.7229772210121155,
-1.081695795059204,
0.11056292057037354,
-0.1623132824897766,
-0.15964479744434357,
-0.45638537406921387,
0.5022515058517456,
-0.10560552030801773,
-0.013776537962257862,
0.06240910664200783,
-0.1803952008485794,
0.30069729685783386,
0.3509995937347412,
0.05582495033740997,
-0.3401167690753937,
-0.3792950510978699,
0.22021612524986267,
0.545146644115448,
0.010785683058202267,
0.36040106415748596,
0.27894628047943115,
0.43086326122283936,
0.2048620730638504,
-0.7388461828231812,
0.34199872612953186,
-0.0037952957209199667,
-0.28758320212364197,
-0.32204678654670715,
-0.31757622957229614,
-0.31733304262161255,
0.022671185433864594,
-0.17731614410877228,
-0.01951139234006405,
-0.31941989064216614,
-0.27330657839775085,
0.09721306711435318,
0.10723334550857544,
-0.014799640513956547,
0.06926610320806503,
0.29274502396583557,
0.24140578508377075,
0.5092766284942627,
-0.05446122959256172,
-0.1581524759531021,
0.2806176543235779,
-0.6798286437988281,
0.6994819045066833,
-0.8666419982910156,
0.6440802216529846,
-0.3406538963317871,
0.0349973663687706,
-0.7164085507392883,
0.08522984385490417,
0.5131290555000305,
0.6442881226539612,
-0.28267911076545715,
-0.2589389979839325,
0.11084430664777756,
0.569953978061676,
-0.11014268547296524,
-0.36910194158554077,
-0.1506182700395584,
-0.5288935899734497,
0.03065352700650692,
-0.5929456949234009,
0.5097132921218872,
-0.15218913555145264,
-0.16910530626773834,
-0.24495737254619598,
0.12280939519405365,
0.5446256995201111,
-0.4235541820526123,
0.08443105220794678,
-0.17250634729862213,
0.46409666538238525,
-0.7534909248352051,
0.10729249566793442,
-0.6673452258110046,
-0.020039048045873642,
0.12901009619235992,
0.13636630773544312,
-0.23211292922496796,
-0.1047719419002533,
0.05332663282752037,
0.03791540861129761,
0.4634426236152649,
-0.44593387842178345,
0.18255488574504852,
0.44104862213134766,
0.5790901780128479,
0.23700445890426636,
-0.6912190914154053,
0.03258684277534485,
0.12076501548290253,
-0.33176401257514954,
-0.024467280134558678,
0.3157062530517578,
-0.09335371851921082,
-0.0817432701587677,
-0.04541994631290436,
-0.27800822257995605,
-0.11620408296585083,
0.7035787105560303
] |
Due to their rapid and widespread development, DNA vaccines have entered into a variety of human clinical trials for vaccines against various diseases including cancer. Evidence that DNA vaccines are well tolerated and have an excellent safety profile proved to be of advantage as many clinical trials combines the first phase with the second, saving both time and money. It is clear from the results obtained in clinical trials that such DNA vaccines require much improvement in antigen expression and delivery methods to make them sufficiently effective in the clinic. Similarly, it is clear that additional strategies are required to activate effective immunity against poorly immunogenic tumor antigens. Engineering vaccine design for manipulating antigen presentation and processing pathways is one of the most important aspects that can be easily handled in the DNA vaccine technology. Several approaches have been investigated including DNA vaccine engineering, co-delivery of immunomodulatory molecules, safe routes of administration, prime-boost regimen and strategies to break the immunosuppressive networks mechanisms adopted by malignant cells to prevent immune cell function. Combined or single strategies to enhance the efficacy and immunogenicity of DNA vaccines are applied in completed and ongoing clinical trials, where the safety and tolerability of the DNA platform are substantiated. In this review on DNA vaccines, salient aspects on this topic going from basic research to the clinic are evaluated. Some representative DNA cancer vaccine studies are also discussed. | [
-0.004104644060134888,
0.0001880275085568428,
-0.025974882766604424,
0.004278314765542746,
0.0030618789605796337,
0.00031449925154447556,
0.009075241163372993,
0.01480171363800764,
-0.01668526604771614,
-0.03561178222298622,
0.005333519075065851,
0.014051106758415699,
-0.008748258464038372,
0.014499090611934662,
-0.024460241198539734,
-0.009420890361070633,
-0.019871624186635017,
-0.024257181212306023,
0.006656627636402845,
0.009601143188774586,
0.035196200013160706,
-0.0014008707366883755,
0.01005222275853157,
-0.01798172853887081,
-0.030687199905514717,
0.03891019523143768,
-0.005214427597820759,
-0.02070356160402298,
-0.024492844939231873,
0.008296852000057697,
-0.012120689265429974,
0.0038507645949721336,
0.035291966050863266,
-0.0033197146840393543,
-0.01212385855615139,
0.002464127726852894,
0.001069024670869112,
0.025230150669813156,
0.0053581115789711475,
-0.002280954271554947,
0.01174955628812313,
-0.011284025385975838,
0.0032370202243328094,
0.0028396344278007746,
-0.004658367484807968,
0.005049673840403557,
-0.0006024662870913744,
0.00696451123803854,
0.022302430123090744,
0.008965684100985527,
0.00039514689706265926,
0.006275506690144539,
-0.010824483819305897,
0.014045256190001965,
-0.006835266947746277,
-0.01191889587789774,
0.019392965361475945,
-0.019481342285871506,
-0.011875666677951813,
-0.004931045696139336,
0.03855151683092117,
-0.052279066294431686,
0.010309126228094101,
-0.0188976489007473,
0.014330841600894928,
-0.06668446213006973,
0.029104173183441162,
0.014488426968455315,
0.02837756648659706,
0.00029493181500583887,
0.035642340779304504,
0.018732950091362,
-0.008714417926967144,
0.022045515477657318,
-0.0007798196747899055,
0.004700245801359415,
0.0029202974401414394,
0.030184844508767128,
0.029953278601169586,
0.0028005572967231274,
-0.03085344471037388,
-0.009626194834709167,
0.012066610157489777,
0.012930241413414478,
0.014564020559191704,
0.018143577501177788,
-0.0023629809729754925,
0.00025614770129323006,
0.008782071061432362,
-0.01112562045454979,
-0.006953801028430462,
-0.023896999657154083,
-0.009631972759962082,
-0.012989400885999203,
-0.01283983699977398,
0.005097086075693369,
0.022652335464954376,
-0.011664334684610367,
0.028424391523003578,
-0.02000228688120842,
-0.008506447076797485,
0.0010594525374472141,
0.012110034003853798,
0.03201987221837044,
0.011725046671926975,
0.009581174701452255,
-0.01909152790904045,
0.03036753088235855,
0.001313564833253622,
0.002741181757301092,
-0.0013618327211588621,
-0.011183206923305988,
-0.006354455836117268,
0.02183794043958187,
0.0048377299681305885,
-0.0017937717493623495,
-0.006853478029370308,
0.001771590206772089,
0.015242388471961021,
0.006116596981883049,
-0.007907221093773842,
-0.03034164570271969,
0.009094692766666412,
-0.008451581932604313,
0.0007043043151497841,
-0.005091815255582333,
-0.017032373696565628,
0.0004907296970486641,
0.027397433295845985,
0.013606068678200245,
-0.009545840322971344,
0.003037143498659134,
-0.01715175062417984,
-0.027980230748653412,
0.00397874228656292,
0.0006874507525935769,
-0.009703239426016808,
-0.009383587166666985,
0.004759751260280609,
-0.024275928735733032,
-0.0072960639372467995,
0.008476153016090393,
-0.0022615911439061165,
0.014875160530209541,
0.0039027866441756487,
0.004996761679649353,
-0.0020728763192892075,
-0.008909481577575207,
-0.033916182816028595,
-0.00620621582493186,
-0.02097127214074135,
-0.0071915253065526485,
-0.008471927605569363,
-0.01809639111161232,
-0.007398666813969612,
-0.004339996725320816,
-0.008580482564866543,
-0.025853898376226425,
-0.026288945227861404,
-0.0017299818573519588,
0.019266024231910706,
-0.030731135979294777,
-0.0034936817828565836,
0.008071845397353172,
0.01617507077753544,
0.005978433880954981,
0.014144567772746086,
-0.0031068683601915836,
0.00830514170229435,
0.002487484598532319,
-0.012422557920217514,
0.026330502703785896,
0.010527051985263824,
0.010815547779202461,
-0.010981887578964233,
-0.0036493483930826187,
0.03880314528942108,
0.006777635775506496,
-0.002401478821411729,
0.0664462000131607,
-0.022647744044661522,
0.0020986786112189293,
-0.03129320591688156,
0.035607874393463135,
0.024419479072093964,
0.0010245925514027476,
0.02140304073691368,
-0.014886254444718361,
0.0045898412354290485,
0.038987770676612854,
-0.0063531287014484406,
0.00491173192858696,
-0.022007718682289124,
0.007252195850014687,
-0.04462672024965286,
0.003324377816170454,
-0.010417474433779716,
-0.000922231818549335,
0.0025473488494753838,
0.014089596457779408,
0.05046643316745758,
0.01681397669017315,
0.02786402776837349,
-0.017180433496832848,
-0.0325641855597496,
0.0069242496974766254,
-0.018516235053539276,
-0.025415752083063126,
-0.009253468364477158,
-0.00041417451575398445,
0.006261794362217188,
0.008007550612092018,
-0.00909610465168953,
0.0022917790338397026,
-0.006931614130735397,
0.009988134726881981,
0.010063228197395802,
-0.021886691451072693,
-0.02142976224422455,
-0.014745648950338364,
0.000742618169169873,
0.041057564318180084,
-0.007205077912658453,
0.013146759942173958,
0.01962408237159252,
0.03097606636583805,
-0.005381154362112284,
0.012621389701962471,
-0.00891614519059658,
0.0022078403271734715,
-0.011683901771903038,
-0.031554050743579865,
-0.008796053007245064,
0.017341112717986107,
0.00448128255084157,
0.014752083458006382,
0.008765926584601402,
-0.015142502263188362,
0.0067624314688146114,
-0.013708719052374363,
-0.013049853965640068,
-0.019588008522987366,
-0.000944922212511301,
0.01239058282226324,
0.017740167677402496,
-0.000804003793746233,
-0.01614009030163288,
0.0036443439312279224,
-0.015393907204270363,
0.0022846588399261236,
0.008662919513881207,
-0.04544588923454285,
0.03597734868526459,
-0.0308920219540596,
0.002346967812627554,
0.006756513379514217,
0.014137038961052895,
-0.012374133802950382,
0.025376614183187485,
-0.011544857174158096,
0.004701044410467148,
0.006893462501466274,
-0.04383155703544617,
-0.02785138413310051,
0.017411373555660248,
0.0340554416179657,
0.006830780766904354,
0.030479947105050087,
0.004910959396511316,
-0.046716704964637756,
0.005905997008085251,
-0.0036832960322499275,
-0.0022460028994828463,
-0.08180242776870728,
-0.010220702737569809,
-0.001477762358263135,
-0.016641128808259964,
0.014357182197272778,
-0.001506185857579112,
0.008892511017620564,
0.01268252544105053,
-0.018117371946573257,
-0.0058948444202542305,
0.029559209942817688,
0.0069846510887146,
-0.00473832618445158,
-0.0020325370132923126,
0.004873440135270357,
-0.010763095691800117,
0.0012009106576442719,
-0.009992225095629692,
-0.03242846205830574,
-0.0320211686193943,
-0.00021797348745167255,
0.02228538505733013,
0.02153893932700157,
-0.01248004101216793,
0.005640694405883551,
-0.002716916147619486,
0.00885324738919735,
0.005392218939960003,
0.0030039814300835133,
0.012062188237905502,
0.030564624816179276,
-0.027393963187932968,
-0.009226303547620773,
0.025433504953980446,
0.0003537635784596205,
0.019982967525720596,
0.0023088250309228897,
-0.004775180481374264,
-0.0002447054721415043,
0.037637725472450256,
0.007479300256818533,
0.017032429575920105,
0.007169387303292751,
0.009643184021115303,
0.020477818325161934,
0.002996413968503475,
0.005765634588897228,
0.05167844146490097,
0.009795166552066803,
-0.0264560729265213,
-0.01015479676425457,
-0.0073962705209851265,
0.0505916029214859,
0.010913778096437454,
-0.009857125580310822,
-0.011191476136446,
-0.002931482158601284,
0.022342612966895103,
-0.020856032148003578,
-0.006511688698083162,
-0.0007234211079776287,
0.014471156522631645,
-0.020850535482168198,
0.017822127789258957,
-0.008835195563733578,
-0.013035979121923447,
0.02248786762356758,
-0.023894809186458588,
-0.012340271845459938,
0.012126635760068893,
-0.0045097689144313335,
-0.032493796199560165,
-0.0032730363309383392,
-0.0035202456638216972,
0.010717933066189289,
-0.008533126674592495,
-0.009985660202801228,
-0.002755131106823683,
0.03135928511619568,
0.009439474903047085,
0.0035034650936722755,
0.001457194797694683,
-0.024168867617845535,
0.00045128725469112396,
-0.012846516445279121,
-0.011195451021194458,
0.0008626790950074792,
0.011388694867491722,
0.0028948457911610603,
-0.018021047115325928,
0.017625214532017708,
-0.00939074158668518,
0.02716747671365738,
0.003954223357141018,
-0.02572062239050865,
-0.01076492853462696,
-0.016254272311925888,
0.006753647234290838,
-0.009700924158096313,
0.010873011313378811,
-0.00015687895938754082,
-0.002474051434546709,
0.01999230682849884,
-0.006661423482000828,
-0.02365770749747753,
0.014703603461384773,
0.009678282774984837,
-0.014078544452786446,
0.011011095717549324,
-0.02121688425540924,
-0.013631532900035381,
-0.007928753271698952,
-0.008732888847589493,
-0.021230380982160568,
0.01212896965444088,
-0.010041352361440659,
-0.007315763272345066,
0.007975229993462563,
0.07191766798496246,
0.014990538358688354,
0.021948833018541336,
-0.01393108069896698,
-0.01794591173529625,
-0.009396504610776901,
0.014007622376084328,
0.015098425559699535,
-0.004816784523427486,
-0.0007811230607330799,
0.013601192273199558,
-0.006294343154877424,
-0.024948589503765106,
-0.0022717369720339775,
-0.014065733179450035,
-0.011541980318725109,
0.028316332027316093,
0.011339046061038971,
-0.0011901950929313898,
-0.012588335201144218,
-0.008635652251541615,
-0.02252127230167389,
-0.014285888522863388,
0.034423135221004486,
-0.005244336556643248,
0.005314211826771498,
0.05287904292345047,
-0.009361767210066319,
-0.0018881196156144142,
-0.0009296352509409189,
0.01621289923787117,
0.002611253410577774,
0.0032600965350866318,
0.02460290677845478,
0.021732039749622345,
0.008952286094427109,
0.022900279611349106,
-0.011800320819020271,
-0.002153349108994007,
0.0018018162809312344,
-0.022306395694613457,
-0.01562063954770565,
-0.010547530837357044,
0.007710765115916729,
0.004844122566282749,
0.014968045987188816,
0.015977414324879646,
-0.005675983615219593,
0.006962371524423361,
0.018689226359128952,
-0.012869948521256447,
0.0019638524390757084,
0.011305329389870167,
0.003007833380252123,
-0.016128232702612877,
0.008200005628168583,
0.007470650598406792,
-0.0055868662893772125,
0.012712018564343452,
-0.018522102385759354,
0.022479474544525146,
-0.011522139422595501,
0.045587167143821716,
-0.016783256083726883,
0.017493166029453278,
-0.0025370800867676735,
0.003943565301597118,
-0.012654556892812252,
-0.04248417168855667,
-0.007653156295418739,
-0.0007295585237443447,
-0.009218689985573292,
0.0074511426500976086,
-0.014388205483555794,
-0.033561304211616516,
0.004384002648293972,
0.0019989381544291973,
-0.025516033172607422,
-0.006568455137312412,
0.009241936728358269,
-0.00782177783548832,
-0.013614501804113388,
0.052135102450847626,
-0.020288968458771706,
-0.008603792637586594,
0.014875208027660847,
0.004265295807272196,
-0.07496890425682068,
-0.01712581142783165,
0.007691602222621441,
-0.010815754532814026,
-0.018541358411312103,
0.0013806261122226715,
-0.017132189124822617,
0.005244389642030001,
0.009222209453582764,
-0.00014161242870613933,
-0.0012379596009850502,
-0.01629013568162918,
0.006047277245670557,
-0.015296725556254387,
0.013370112515985966,
0.027056211605668068,
-0.04007605463266373,
-0.009597263298928738,
-0.018199371173977852,
-0.017151644453406334,
-0.005039476789534092,
0.0034668254666030407,
-0.022511683404445648,
0.0005505410954356194,
-0.006389263551682234,
-0.0810701996088028,
0.013007987290620804,
0.003280888544395566,
-0.02819686010479927,
-0.030855756253004074,
-0.02292625606060028,
0.0015540560707449913,
-0.00836444366723299,
-0.012003200128674507,
-0.018109627068042755,
0.013358067721128464,
-0.005960555747151375,
-0.007250119000673294,
0.007770047057420015,
0.0026002489030361176,
-0.0072547513991594315,
-0.0198872871696949,
-0.008040517568588257,
0.01608811691403389,
0.005542796570807695,
-0.0012314156629145145,
-0.0050505418330430984,
-0.008527671918272972,
-0.01588243991136551,
-0.013305721804499626,
-0.027120858430862427,
-0.009474419057369232,
0.016060691326856613,
0.000981190474703908,
-0.0218430757522583,
0.024264171719551086,
-0.04176929220557213,
-0.020170237869024277,
-0.01463409885764122,
0.03742094337940216,
-0.00989651121199131,
-0.02386413887143135,
0.0021168007515370846,
0.019845739006996155,
-0.0014636088162660599,
-0.0039560217410326,
0.023160267621278763,
0.002727956511080265,
0.026575695723295212,
0.007505334448069334,
-0.0350201353430748,
0.009147433564066887,
0.0017688077641651034,
0.010775892063975334,
-0.010783418081700802,
0.0010038117179647088,
-0.011922433041036129,
-0.0028966539539396763,
-0.007768802344799042,
0.0031498163007199764,
-0.009918446652591228,
-0.0044388845562934875,
0.0021912534721195698,
-0.010159950703382492,
0.016848735511302948,
-0.011694516986608505,
0.007691207341849804,
-0.0074471039697527885,
0.07100318372249603,
-0.0008946657180786133,
0.014698194339871407,
-0.025974638760089874,
-0.009646597318351269,
-0.004398623015731573,
-0.0041359285824000835,
-0.008638819679617882,
-0.00890478678047657,
-0.007588464301079512,
0.01846829056739807,
0.006235762499272823,
0.007309326436370611,
0.0034023101907223463,
-0.027616746723651886,
0.009495191276073456,
0.0013595873024314642,
0.005148770287632942,
0.006277954671531916,
-0.020068690180778503,
0.0007253200747072697,
0.011115975677967072,
-0.04064500331878662,
0.010358131490647793,
-0.013361004181206226,
-0.008541790768504143,
-0.031357329338788986,
-0.05325756594538689,
-0.0006783920107409358,
-0.0027929029893130064,
0.021591272205114365,
0.018249401822686195,
-0.0007405016804113984,
0.011895546689629555,
0.0092189721763134,
0.0021071587689220905,
0.013427354395389557,
-0.005881153978407383,
-0.008063968271017075,
0.015855489298701286,
-0.011659722775220871,
-0.002234285231679678,
0.0035574063658714294,
0.00566630344837904,
0.01394454762339592,
-0.028344128280878067,
-0.014735225588083267,
0.007473706733435392,
0.0127837173640728,
0.01819157786667347,
0.02081257849931717,
-0.0021524964831769466,
-0.015926219522953033,
0.0061031063087284565,
0.008075898513197899,
0.008865498006343842,
-0.012805075384676456,
0.025579407811164856,
0.0029823067598044872,
0.008861150592565536,
0.027323490008711815,
-0.021335747092962265,
-0.013044712133705616,
-0.011935198679566383,
0.014874350279569626,
-0.035892732441425323,
0.008367905393242836,
-0.022874388843774796,
0.006166878156363964,
0.013008186593651772,
0.0016344590112566948,
0.0011508949100971222,
0.0016365296905860305,
-0.01557399332523346,
0.015967857092618942,
-0.003032045904546976,
0.016726765781641006,
0.00690258527174592,
0.017304297536611557,
0.0009025846375152469,
-0.00327736116014421,
0.039054542779922485,
0.025398526340723038,
0.012932682409882545,
-0.020676029846072197,
0.02210868149995804,
0.021579541265964508,
0.023064110428094864,
-0.00848877802491188,
0.009460721164941788,
0.024469392374157906,
0.009450417943298817,
0.0029840385541319847,
0.017681892961263657,
0.005278689321130514,
0.03585204482078552,
0.0033433656208217144,
0.014394029043614864,
0.03128239884972572,
0.0005598998395726085,
0.037407148629426956,
-0.008287793025374413,
-0.044890403747558594,
-0.010748135857284069,
0.0015635730233043432,
-0.002007292117923498,
0.04557399824261665,
-0.03323905169963837,
-0.004896160215139389,
-0.00489434041082859,
0.003795711323618889,
-0.0048951394855976105,
0.007293607108294964,
0.0061467494815588,
0.00686714518815279,
-0.0062713478691875935,
-0.010706146247684956,
0.004353344906121492,
0.0011896337382495403,
-0.007726335898041725,
-0.020926065742969513,
0.012657423503696918,
0.009244590997695923,
0.03148631751537323,
-0.024850718677043915,
-0.013059386983513832,
-0.017199892550706863,
0.004060909617692232,
-0.01681455597281456,
0.004642406944185495,
0.002990039996802807,
-0.0027770930901169777,
0.0005006985738873482,
0.015212472528219223,
0.031587544828653336,
-0.013345473445951939,
-0.02073664963245392,
-0.013817000202834606,
-0.013580035418272018,
0.0188757237046957,
0.003431143006309867,
-0.0003457881975919008,
-0.010699506849050522,
0.0018547362415120006,
0.009080304764211178,
0.004622024018317461,
-0.015340391546487808,
0.012673955410718918,
0.004182352684438229,
0.008957701735198498,
0.005643286742269993,
0.02112095057964325,
-0.02145656943321228,
-0.004469473380595446,
-0.008712735958397388,
0.020057056099176407,
0.011301983147859573,
0.029180249199271202,
-0.018973130732774734,
0.006372432224452496,
0.019548211246728897,
0.014920475892722607,
0.04269629344344139,
0.006582359783351421,
-0.011285610496997833,
0.014382919296622276,
0.00813604611903429,
-0.005086967721581459,
0.017170457169413567,
-0.011033575050532818,
0.018650049343705177,
-0.0017446993151679635,
-0.004975753836333752,
0.01688443496823311,
-0.031742602586746216,
-0.0002850801683962345,
-0.03166963905096054,
-0.0015106056816875935,
-0.03412790969014168,
0.006852354854345322,
0.032036248594522476,
-0.008955873548984528,
-0.0013601871905848384,
-0.005828459747135639,
-0.018804678693413734,
-0.0011261031031608582,
-0.00909324549138546,
0.004747435450553894,
0.014524615369737148,
-0.002037664642557502,
-0.001708810217678547,
-0.024752043187618256,
-0.012907621450722218,
-0.009437117725610733,
0.0012157263699918985,
-0.03178723156452179,
0.009421532042324543,
0.005471719428896904,
0.0035608878824859858,
0.015323873609304428,
0.011822009459137917,
-0.015846196562051773
] | [
0.5570069551467896,
0.1705910861492157,
-0.26493820548057556,
-0.10676845163106918,
-0.026188084855675697,
-0.16852536797523499,
0.46054935455322266,
-0.38867729902267456,
0.16292397677898407,
-0.7497906684875488,
0.2763981819152832,
0.3195672631263733,
-0.36944010853767395,
0.44827160239219666,
-0.398699551820755,
0.6085300445556641,
0.2237665206193924,
0.4081086814403534,
0.020254556089639664,
-0.07104115188121796,
-0.4884326756000519,
-0.16431115567684174,
0.21971498429775238,
-0.06644640862941742,
-0.20454588532447815,
0.0992920771241188,
0.6324924230575562,
-0.042792029678821564,
-0.06375272572040558,
-0.1204804852604866,
-0.01929265446960926,
0.2840566337108612,
-0.5742590427398682,
0.06389757990837097,
0.0074669476598501205,
-0.19091276824474335,
-0.28623589873313904,
0.04807355999946594,
-0.13858652114868164,
-0.5287312269210815,
-0.1806066930294037,
-0.41719600558280945,
-0.022845245897769928,
0.45636025071144104,
-0.31869181990623474,
-0.647087574005127,
-1.4629535675048828,
0.6599520444869995,
-0.3322473168373108,
0.12446338683366776,
0.10981692373752594,
-0.21205703914165497,
-0.20195072889328003,
0.27135616540908813,
0.3505309820175171,
0.5917540788650513,
-0.35653039813041687,
0.036147162318229675,
0.38679713010787964,
-0.31850531697273254,
0.08839865773916245,
-0.12225489318370819,
-0.27596578001976013,
0.3978051543235779,
0.10825008153915405,
0.23802627623081207,
0.2927002012729645,
0.24077579379081726,
-0.39777401089668274,
-0.714157223701477,
-0.05648203566670418,
-0.6870061159133911,
0.041719138622283936,
0.6643096208572388,
-0.022694440558552742,
-0.13918249309062958,
-0.18680982291698456,
-0.4841727018356323,
0.3337932527065277,
-0.0340769924223423,
0.033362679183483124,
0.2559954524040222,
-0.1568370759487152,
-0.02037659101188183,
0.5508354902267456,
0.004446667153388262,
0.16164758801460266,
1.0062379837036133,
-0.6207658648490906,
-0.03899810463190079,
0.23761650919914246,
-0.0791059359908104,
0.2759205102920532,
0.21581721305847168,
0.2236049473285675,
0.25042739510536194,
-0.32284584641456604,
0.023340020328760147,
0.2583012580871582,
0.1856497824192047,
-0.22449688613414764,
-0.32282575964927673,
0.04769570380449295,
-0.489904522895813,
-0.5639532208442688,
-0.34050270915031433,
-0.5234513878822327,
-0.5083574056625366,
-0.6166188716888428,
0.08120919018983841,
-0.17140664160251617,
0.3781493008136749,
-0.24053560197353363,
-0.09984809905290604,
-0.6715671420097351,
0.23956507444381714,
0.3722822368144989,
-0.09874115139245987,
-0.3686109781265259,
0.06701110303401947,
-0.11935120075941086,
1.590932011604309,
-0.3724750578403473,
0.33149057626724243,
0.029550688341259956,
0.0355072058737278,
0.6033101677894592,
0.5362008213996887,
-0.2072979211807251,
0.31496065855026245,
0.06565652787685394,
0.7451340556144714,
-0.3062087893486023,
-0.004199934657663107,
0.06821757555007935,
-0.348320871591568,
-0.19415710866451263,
-0.12453358620405197,
0.08061441779136658,
-0.5351601243019104,
-0.662765383720398,
-0.6668585538864136,
0.23366336524486542,
0.10182568430900574,
0.17571870982646942,
0.035543929785490036,
-0.16129876673221588,
-0.05032624304294586,
-0.4606006145477295,
0.05848000571131706,
0.057464297860860825,
-0.10524660348892212,
-0.5930041670799255,
0.4621034860610962,
0.1301758736371994,
0.6388474106788635,
0.19366192817687988,
-0.2124495506286621,
0.07950258255004883,
0.1801900714635849,
0.28237631916999817,
0.08926744759082794,
-0.5292536616325378,
-0.27577468752861023,
0.15106365084648132,
-0.30756017565727234,
0.5331832766532898,
0.7897815704345703,
0.07546254247426987,
-0.4497215151786804,
-0.48587101697921753,
-0.01699952408671379,
-0.11260466277599335,
-0.20656855404376984,
0.05785900354385376,
-0.2614879012107849,
0.1835671365261078,
-0.1064239963889122,
0.20674842596054077,
0.5417572855949402,
-0.5755454301834106,
-0.006546752527356148,
0.1573573648929596,
-0.24186845123767853,
0.5353694558143616,
-0.0808047279715538,
0.4512656331062317,
-0.04753696918487549,
-0.23373286426067352,
0.03574664890766144,
-0.5624116659164429,
-0.0632157251238823,
0.288828581571579,
-0.5926403403282166,
1.2047374248504639,
0.009582243859767914,
-0.2260577231645584,
1.688583493232727,
0.04727688059210777,
-0.23720848560333252,
-0.13914410769939423,
0.4796535074710846,
0.19561725854873657,
-0.30335456132888794,
-0.8819532990455627,
-0.37474533915519714,
0.5546162724494934,
-0.36424025893211365,
-0.46518126130104065,
0.1528216451406479,
1.2097399234771729,
-0.06684394925832748,
-0.031096287071704865,
-0.3342503309249878,
-0.012368789874017239,
0.30913791060447693,
0.07927365601062775,
0.5726330876350403,
-0.2966736853122711,
0.19333568215370178,
0.32967767119407654,
-0.5401580333709717,
0.3739895820617676,
0.7234807014465332,
0.4320584833621979,
0.8988646268844604,
0.3119945824146271,
-0.15112784504890442,
0.5236616134643555,
-0.2156437486410141,
0.2083197832107544,
-0.5625324845314026,
0.5551757216453552,
-0.6248036026954651,
-0.30917564034461975,
0.12269701808691025,
0.05239081382751465,
-0.12194004654884338,
0.03158358857035637,
0.24931396543979645,
0.24418126046657562,
0.5142768025398254,
-0.515657901763916,
0.02164173126220703,
0.20154157280921936,
-0.2636955976486206,
-0.21782687306404114,
-0.2642061710357666,
-0.4394560754299164,
-0.2849695086479187,
-0.031009096652269363,
-0.030973827466368675,
0.479017972946167,
-0.49053332209587097,
0.5221840739250183,
-0.015395726077258587,
-0.2745454013347626,
-0.45034700632095337,
0.016676371917128563,
-0.3346377909183502,
-0.18413306772708893,
0.03271527588367462,
0.035967614501714706,
-0.227963387966156,
-0.30042392015457153,
-0.390147864818573,
-0.4898086190223694,
-0.7497383952140808,
0.3155481517314911,
0.8636942505836487,
0.7381525039672852,
0.3068583309650421,
-0.5977481603622437,
-0.09720373898744583,
-0.15267202258110046,
-0.790026068687439,
0.04388655722141266,
0.4871690273284912,
-0.5704050660133362,
-0.23851227760314941,
0.04772603139281273,
0.6463545560836792,
0.7985643148422241,
-0.8336992859840393,
-0.8341712951660156,
-0.34160980582237244,
0.3619018495082855,
-0.6062895059585571,
-0.9959750175476074,
0.28055906295776367,
-0.28186947107315063,
0.2663322687149048,
-0.40441232919692993,
0.0382096990942955,
0.3329940438270569,
-0.036618929356336594,
-0.08018956333398819,
0.2036181092262268,
0.6649366617202759,
-0.07078332453966141,
-0.15379053354263306,
0.29245567321777344,
-0.19334658980369568,
-0.2655448019504547,
-0.03392748162150383,
-0.1400631219148636,
0.016785062849521637,
0.11883749067783356,
-5.869289398193359,
-0.42358890175819397,
-0.1255641132593155,
0.06883671134710312,
-0.17867940664291382,
-0.03553192317485809,
1.0363082885742188,
-0.33782482147216797,
0.5084133148193359,
-0.06992447376251221,
0.42560797929763794,
0.7185845971107483,
0.24222728610038757,
-0.1476067751646042,
-0.030185380950570107,
0.055462345480918884,
0.6946819424629211,
0.1881745159626007,
0.7080999612808228,
0.12568381428718567,
0.6941948533058167,
-0.0169074647128582,
-0.3703126013278961,
0.8178809285163879,
-0.1113070473074913,
-0.3411794602870941,
-0.7973804473876953,
0.31891974806785583,
-0.20229335129261017,
-0.06305055320262909,
0.2432117611169815,
-0.0668368935585022,
0.2164592146873474,
-0.28814613819122314,
0.1369219869375229,
0.4463758170604706,
-0.07343433797359467,
-0.2751091420650482,
0.10437312722206116,
-0.461546391248703,
0.6459247469902039,
0.20128880441188812,
0.09681987762451172,
-0.19811338186264038,
0.11327560245990753,
-0.6368528604507446,
0.056457504630088806,
0.48751702904701233,
0.1611688882112503,
0.6544170379638672,
0.07507255673408508,
-0.03853670135140419,
0.7738635540008545,
0.3062776029109955,
-0.1727365106344223,
-0.1874568611383438,
-0.004797877743840218,
0.1256907433271408,
-0.382500559091568,
0.281145304441452,
-0.4291113317012787,
-0.3442745804786682,
-0.1252449005842209,
-0.25218114256858826,
-0.06437057256698608,
0.29729798436164856,
0.00162815663497895,
-0.9212496876716614,
0.042694807052612305,
0.1990717500448227,
-0.7475042343139648,
0.5641223788261414,
0.4861682057380676,
-0.44962096214294434,
0.6157683730125427,
-0.5668413043022156,
0.003810980124399066,
0.22700263559818268,
-0.31942546367645264,
0.30158793926239014,
-0.9342715740203857,
-0.4933684766292572,
-0.09415896236896515,
-0.11487936228513718,
0.4039559066295624,
-0.4625002145767212,
-0.2011183351278305,
0.07019668817520142,
-0.10483098030090332,
0.026709023863077164,
0.7953355312347412,
-0.3608536720275879,
0.30081620812416077,
0.4857291579246521,
0.4209209382534027,
0.5636618137359619,
0.22063584625720978,
0.2893221974372864,
0.49761253595352173,
-0.10282006114721298,
0.5447145700454712,
0.4062459170818329,
-0.2854622006416321,
-0.9548766613006592,
-0.09019934386014938,
0.001490169670432806,
-0.29172512888908386,
-0.1808960735797882,
0.4138796925544739,
-0.7413102984428406,
-0.2745131552219391,
-0.024761224165558815,
-0.2067795842885971,
0.19417762756347656,
0.5775397419929504,
-0.33773118257522583,
0.22425706684589386,
0.2626912295818329,
0.6880060434341431,
-0.1776554137468338,
0.43507295846939087,
0.43971720337867737,
-0.6517374515533447,
0.27011555433273315,
0.5494147539138794,
-0.34368768334388733,
0.28023234009742737,
0.5923572778701782,
-0.4360430836677551,
-0.2889188826084137,
0.40240925550460815,
0.49285635352134705,
-0.5772676467895508,
-0.029076505452394485,
-0.13773827254772186,
0.15307831764221191,
-0.4675373136997223,
-0.009951970539987087,
-0.25486454367637634,
-0.48879122734069824,
0.17364925146102905,
-0.3123089671134949,
0.06259845942258835,
0.07697837054729462,
0.2242099940776825,
-0.060910727828741074,
0.05920061096549034,
0.1369793713092804,
-0.2902391850948334,
-0.0819273442029953,
-0.1758243590593338,
-0.013198213651776314,
-0.05080943554639816,
-0.4074989855289459,
-0.1129046380519867,
0.44787120819091797,
0.9335853457450867,
0.001315510249696672,
0.3703712224960327,
-0.5432382225990295,
0.13518832623958588,
0.3927450478076935,
-1.1863502264022827,
0.23315641283988953,
-0.03526391088962555,
-0.018212586641311646,
-0.350922167301178,
-0.04339560493826866,
-0.008228224702179432,
0.36150288581848145,
-0.5527409911155701,
-0.3970123529434204,
-0.2900601923465729,
-0.048637352883815765,
0.2025013267993927,
-0.08726602047681808,
-0.21260227262973785,
-0.049179330468177795,
-0.5252771973609924,
-0.1871776282787323,
0.4331592917442322,
-0.799590528011322,
-0.2284713089466095,
0.45256197452545166,
0.4674686789512634,
0.026174819096922874,
-0.31553134322166443,
-0.15075300633907318,
-0.6038883328437805,
-0.28803905844688416,
0.16180860996246338,
0.22842690348625183,
0.4122987687587738,
-0.33298829197883606,
-0.20800088346004486,
-0.09648478776216507,
-0.35878947377204895,
0.12909801304340363,
0.12033475190401077,
-0.7436240315437317,
0.041849926114082336,
0.39956536889076233,
-0.6659776568412781,
0.02312716282904148,
-0.09322769194841385,
-0.12114473432302475,
-0.30634555220603943,
0.3601667582988739,
0.28616565465927124,
0.03335198387503624,
-0.3493747115135193,
-0.5736654996871948,
0.46737924218177795,
0.4185427129268646,
-0.22210247814655304,
0.3341089189052582,
-0.052967678755521774,
-0.038722455501556396,
-0.05870416760444641,
0.22122716903686523,
0.3028075098991394,
-0.6177687644958496,
-0.2916358709335327,
0.04708491638302803,
-0.40639355778694153,
-0.014287729747593403,
0.20825695991516113,
-0.9756856560707092,
0.021407729014754295,
0.10610222071409225,
-0.1665232628583908,
-0.2409510463476181,
0.08373644202947617,
0.26543503999710083,
-0.2032042294740677,
-0.320907324552536,
-0.07188650965690613,
0.573122501373291,
0.0666525587439537,
-0.15917083621025085,
0.38151711225509644,
0.23193825781345367,
-0.6188052296638489,
0.03300022706389427,
-0.3047623932361603,
0.07072780281305313,
0.48976391553878784,
-0.42769843339920044,
-0.7539278268814087,
0.4107542932033539,
-0.07915099710226059,
-0.08617206662893295,
-0.09553725272417068,
0.127618670463562,
0.5302450656890869,
0.2777794301509857,
0.14599505066871643,
-0.1736326366662979,
-0.15336117148399353,
0.20214124023914337,
-0.09326698631048203,
0.13327720761299133,
-0.7542253732681274,
-0.42476439476013184,
0.3720841705799103,
-0.06685270369052887,
-0.2187075912952423,
-0.7965764999389648,
0.5235785841941833,
0.1421925276517868,
-0.21650633215904236,
0.02877069264650345,
0.5852819085121155,
0.5221074819564819,
-0.07862826436758041,
0.22378726303577423,
-0.3618106245994568,
0.07977797091007233,
0.0365355908870697,
0.6165209412574768,
-0.06558472663164139,
-0.31161215901374817,
0.6475319862365723,
-0.7407341003417969,
-0.1537197232246399,
-0.32808831334114075,
0.16479013860225677,
-0.37938016653060913,
0.35208022594451904,
-0.29253384470939636,
0.013575591146945953,
-0.10630489885807037,
-0.6632219552993774,
-0.5345335006713867,
0.11325651407241821,
0.23449087142944336,
0.3252582848072052,
0.2733851373195648,
-0.28393474221229553,
-0.5059754848480225,
-0.3771055042743683,
0.7968547940254211,
0.6041512489318848,
-0.6554213166236877,
0.25240930914878845,
0.41040027141571045,
0.6397859454154968,
0.2731113135814667,
-0.2004396915435791,
0.048244621604681015,
-0.18957406282424927,
-0.042616404592990875,
0.6862898468971252,
0.6530107855796814,
-0.5818326473236084,
0.4374086260795593,
0.013545341789722443,
-0.24505500495433807,
0.3825818598270416,
-0.2595177888870239,
0.12082502245903015,
0.14289942383766174,
0.309455931186676,
-0.5921920537948608,
-0.5722374320030212,
0.6881647706031799,
-0.16075940430164337,
-0.2453175038099289,
-0.170643612742424,
0.4465393126010895,
0.3944263160228729,
0.4997765123844147,
-0.18112242221832275,
0.04899575933814049,
0.20352305471897125,
0.16051417589187622,
0.016182200983166695,
-0.1879306435585022,
-0.1636725664138794,
0.17389114201068878,
0.13478021323680878,
-0.06761330366134644,
-0.38982996344566345,
0.18617233633995056,
-0.18071113526821136,
0.5080142617225647,
-0.03802090883255005,
0.3440437912940979,
-0.1377979815006256,
0.5866765379905701,
0.16140009462833405,
-0.18524768948554993,
-0.29324018955230713,
0.582858681678772,
-0.29165297746658325,
-0.4767077565193176,
0.5347703099250793,
-0.36202722787857056,
0.02718120999634266,
0.10716434568166733,
0.24903325736522675,
0.39977508783340454,
-0.02352250926196575,
0.5002583861351013,
-0.20733708143234253,
0.16383206844329834,
0.9806721210479736,
-0.03439013659954071,
0.10639326274394989,
-0.22081924974918365,
-0.16766847670078278,
-0.044035401195287704,
-0.2495996505022049,
0.3748573958873749,
0.17350813746452332,
-0.612001359462738,
0.19698598980903625,
-0.2364068627357483,
-0.23566608130931854,
0.23009738326072693,
-0.12122427672147751,
-0.2808028757572174,
-0.2889370620250702,
-0.7779667973518372,
-0.33586251735687256,
0.07108653336763382,
-0.7261227369308472,
0.020887328311800957,
0.07492153346538544,
0.05923180282115936,
0.63508540391922,
-0.41101354360580444,
-0.13283692300319672,
0.4952530860900879,
-0.05704153701663017,
-0.4595412611961365,
0.0997854471206665,
0.5329093933105469,
-0.06751368939876556,
0.45793846249580383,
0.18575243651866913,
0.5915690064430237,
-0.05171164870262146,
0.3723394572734833,
-0.7197101712226868,
0.3355414569377899,
-0.47575125098228455,
0.04988903924822807,
-0.6980942487716675,
-0.015284985303878784,
0.9523373246192932,
0.12783899903297424,
-0.11994961649179459,
-0.2168298363685608,
-0.3758068382740021,
0.2157071977853775,
0.27085942029953003,
-0.4777628183364868,
0.38638606667518616,
-0.18066775798797607,
0.16579504311084747,
-0.5931540727615356,
0.5457698702812195,
0.04391024261713028,
-0.3283560872077942,
-0.2876015603542328,
0.4691925048828125,
0.4520311653614044,
-0.48233652114868164,
0.5791887044906616,
0.03230958431959152,
0.36618345975875854,
-0.21505023539066315,
0.361453652381897,
-0.5379632115364075,
-0.4697923958301544,
-0.08694189041852951,
0.294418603181839,
0.2126816213130951,
-0.011442000977694988,
-0.12852859497070312,
-0.16855692863464355,
0.257649689912796,
0.2235763669013977,
0.09953702986240387,
-0.02540777437388897,
-0.0019047181122004986,
-0.3817926049232483,
-0.3643040657043457,
0.4009304642677307,
-0.2874149978160858,
0.06259143352508545,
-0.10378804802894592,
0.3755922019481659,
-0.22386644780635834,
0.2904806435108185,
-0.08229892700910568,
-0.473419725894928,
-0.22956126928329468,
-0.16965986788272858
] |
Efficient delivery of siRNA to specific cell populations in vivo remains a formidable challenge to its successful therapeutic application. We describe a novel siRNA-based approach – synthetically linking siRNA to an oligonucleotide TLR9 agonist – that targets and silences genes in TLR9(+) myeloid cells and B cells, both of which are key components of the tumor microenvironment. Because Stat3 in tumor-associated immune cells suppresses antitumor immune responses and hinders TLR9-induced immune stimulation, we tested CpG-Stat3siRNA conjugates for anti-tumor effects. When injected locally at the tumor site or systemically through an intravenous route, the CpG-Stat3siRNA conjugates access tumor-associated dendritic cells, macrophages and B cells, inhibit Stat3 expression, leading to activation of tumor-associated immune cells, and ultimately potent anti-tumor immune responses. Our findings demonstrate the potential of TLR agonist-siRNA conjugates for targeted gene silencing coupled with TLR stimulation and immune activation in the tumor microenvironment. | [
-0.003061785129830241,
0.004034227225929499,
-0.006251050624996424,
0.014414929784834385,
-0.0020199199207127094,
-0.003262660466134548,
0.01095500960946083,
0.010212576948106289,
-0.011692000553011894,
-0.02221926674246788,
-0.015770718455314636,
0.0035077016800642014,
-0.01610233448445797,
0.026548806577920914,
0.01578802429139614,
0.007102747447788715,
-0.019728349521756172,
-0.007287083193659782,
0.008983214385807514,
0.015274671837687492,
0.04312543943524361,
-0.008686807006597519,
0.010413034819066525,
0.0027310058940201998,
-0.006054588593542576,
0.014568614773452282,
-0.024808108806610107,
-0.007376444526016712,
-0.012374061159789562,
-0.018487930297851562,
0.007080333307385445,
0.011383524164557457,
0.03255914896726608,
0.004689278081059456,
-0.002203430514782667,
0.0071386792697012424,
-0.0019146292470395565,
0.02267463319003582,
0.028582096099853516,
-0.005452149081975222,
0.009159136563539505,
-0.009814297780394554,
0.0032769101671874523,
-0.013996387831866741,
-0.00872114673256874,
-0.0023670359514653683,
-0.005078003741800785,
0.028925206512212753,
0.006590895354747772,
0.0057012843899428844,
0.0015137959271669388,
-0.02784210443496704,
-0.01405087485909462,
0.022846799343824387,
-0.006155472714453936,
-0.0033501996658742428,
0.018579445779323578,
-0.0207385066896677,
-0.01705389842391014,
0.016213081777095795,
0.014682273380458355,
-0.016864171251654625,
0.02556191384792328,
-0.02951621450483799,
-0.0025385739281773567,
-0.0668489933013916,
0.014688918367028236,
-0.004280413500964642,
0.002900929655879736,
0.009969252161681652,
-0.0036167376674711704,
0.008704068139195442,
-0.028328638523817062,
-0.0121624656021595,
-0.03454532474279404,
0.010217076167464256,
-0.006702025420963764,
-0.002383763901889324,
0.011046169325709343,
0.009886645711958408,
0.022693607956171036,
0.007589974440634251,
0.009169699624180794,
-0.0014562566066160798,
0.0014645745977759361,
0.019706379622220993,
-0.019575584679841995,
-0.0002248077653348446,
0.0021553239785134792,
-0.016173409298062325,
0.0000634538009762764,
0.021461157128214836,
-0.01602947898209095,
0.01913875713944435,
-0.011407079175114632,
0.0014135772362351418,
-0.006536091212183237,
-0.0025206508580595255,
-0.0030222670175135136,
-0.0033369113225489855,
-0.012058956548571587,
0.007169852964580059,
0.01570524461567402,
0.02520911395549774,
-0.00822596624493599,
0.00970076397061348,
0.003146965755149722,
0.02356666885316372,
0.014643030241131783,
0.010211658664047718,
0.0014743647770956159,
-0.022495554760098457,
-0.0067916326224803925,
0.004530556499958038,
-0.008132535964250565,
-0.004880731459707022,
-0.012919044122099876,
0.010378488339483738,
0.007648971863090992,
0.00035493308678269386,
-0.00010402360931038857,
-0.01095310878008604,
-0.0016421996988356113,
-0.004718419164419174,
0.004554505459964275,
0.0011815587058663368,
-0.0018923915922641754,
0.004159253090620041,
0.007844965904951096,
0.00021394668146967888,
-0.008169760927557945,
-0.0069417767226696014,
0.0093078026548028,
-0.03331432864069939,
-0.021430186927318573,
0.0014949280302971601,
0.004675040487200022,
0.006415903568267822,
-0.0043159169144928455,
-0.011743646115064621,
-0.014697333797812462,
0.007120594382286072,
-0.005700308829545975,
0.013176800683140755,
0.0036303135566413403,
-0.00597920548170805,
-0.0006870082579553127,
-0.007615226320922375,
-0.0019315360113978386,
-0.008579244837164879,
-0.017299367114901543,
0.0160368625074625,
-0.010793435387313366,
-0.015978243201971054,
0.017024874687194824,
0.021393802016973495,
-0.02284962125122547,
-0.030712779611349106,
0.0004997603828087449,
-0.0065186950378119946,
0.012559689581394196,
-0.016859807074069977,
0.010935354977846146,
0.009730224497616291,
0.033269595354795456,
-0.0038533061742782593,
-0.002908003516495228,
-0.00042371032759547234,
0.022284436970949173,
0.003481498220935464,
-0.00948636420071125,
0.00225183367729187,
0.020355867221951485,
0.004318311344832182,
0.004957354627549648,
-0.0010343736503273249,
0.01233695074915886,
0.006372082978487015,
-0.011770861223340034,
0.06644132733345032,
0.005099604371935129,
0.0031395559199154377,
0.027726951986551285,
-0.017202533781528473,
0.0036744014360010624,
-0.03194320946931839,
-0.003980850800871849,
-0.0012885632459074259,
-0.01936909556388855,
0.019460460171103477,
0.01998765766620636,
-0.01525295339524746,
-0.028207145631313324,
0.005895587150007486,
-0.02479274943470955,
0.0019917720928788185,
0.0076528326608240604,
0.006111390423029661,
-0.008993936702609062,
0.01932191289961338,
0.010021798312664032,
-0.002366526983678341,
0.0371868871152401,
0.007407856173813343,
-0.014254704117774963,
0.0017818990163505077,
-0.005742394365370274,
-0.030397281050682068,
0.008800290524959564,
-0.017539571970701218,
0.02929595485329628,
-0.021042965352535248,
-0.004222503863275051,
-0.016244925558567047,
0.01754026487469673,
0.008553075604140759,
0.005656542256474495,
0.012907909229397774,
-0.0010199439711868763,
-0.011634319089353085,
-0.0017195799155160785,
0.02474970929324627,
0.003901122137904167,
0.003989510703831911,
0.02696855552494526,
0.006044598761945963,
-0.0037258192896842957,
0.009522579610347748,
-0.0011752232676371932,
-0.0012781030964106321,
-0.0003447975032031536,
-0.024119460955262184,
-0.012234690599143505,
0.021887004375457764,
-0.008505403064191341,
0.013700061477720737,
0.013855722732841969,
-0.010587175376713276,
0.013348719105124474,
-0.012527486309409142,
0.005724762566387653,
-0.022960083559155464,
0.022098150104284286,
-0.03205164894461632,
-0.011765283532440662,
-0.0009415149688720703,
0.02573552541434765,
0.014795500785112381,
0.01594976894557476,
-0.014116289094090462,
0.0056355115957558155,
-0.012174584902822971,
0.010115637443959713,
-0.01567070186138153,
0.0058952998369932175,
0.008348180912435055,
0.00929970107972622,
0.0009237839840352535,
0.02605554275214672,
-0.00263214111328125,
-0.004977175034582615,
0.005533724091947079,
-0.007237099576741457,
0.0030286209657788277,
-0.00895579345524311,
0.022944150492548943,
-0.009134052321314812,
0.004109418485313654,
0.017176635563373566,
0.005903060548007488,
0.006991424597799778,
-0.0034758341498672962,
0.00982631929218769,
-0.08178731799125671,
-0.005416959058493376,
0.010135015472769737,
-0.004687957465648651,
0.005068470723927021,
0.002659775782376528,
0.004513596184551716,
0.026777446269989014,
-0.0023189871571958065,
0.016155216842889786,
-0.007137528620660305,
0.015474030748009682,
-0.009674809873104095,
-0.01364976353943348,
-0.00029226765036582947,
-0.008873817510902882,
0.009147554636001587,
0.01840735226869583,
-0.002756158821284771,
-0.04558362811803818,
-0.013611586764454842,
-0.013780487701296806,
0.032169125974178314,
0.001020893920212984,
-0.032119568437337875,
0.023632239550352097,
-0.0015558409504592419,
-0.0011064223945140839,
0.006523930002003908,
-0.0020519099198281765,
-0.015604832209646702,
-0.0018866616301238537,
0.0035607239697128534,
0.0198516808450222,
0.01089298166334629,
0.022931907325983047,
-0.01188196986913681,
-0.007582189980894327,
-0.00995598640292883,
0.03068295493721962,
-0.012457325123250484,
0.00862941425293684,
-0.0055548036471009254,
-0.008242955431342125,
0.031153110787272453,
0.0042866989970207214,
-0.016823528334498405,
0.043490052223205566,
0.015642736107110977,
0.004850320052355528,
0.017066869884729385,
0.004077363293617964,
-0.012703819200396538,
0.022317206487059593,
-0.0028663468547165394,
-0.004279776476323605,
-0.02029510587453842,
0.004715528804808855,
-0.012183902785182,
-0.00659865140914917,
0.025189407169818878,
-0.012002497911453247,
0.02380879782140255,
0.0288398340344429,
0.020022857934236526,
-0.013159230351448059,
0.0075035844929516315,
0.008550994098186493,
-0.003537331707775593,
0.009286800399422646,
-0.021565061062574387,
0.0027041584253311157,
-0.0031456872820854187,
-0.0014969182666391134,
-0.020540688186883926,
-0.01289144903421402,
-0.015337498858571053,
-0.014972101897001266,
-0.007961634546518326,
-0.01411572564393282,
0.027532918378710747,
-0.0014394265599548817,
-0.012126950547099113,
-0.004583423957228661,
-0.020625147968530655,
-0.014322987757623196,
0.005313301924616098,
0.021341245621442795,
0.0075456248596310616,
-0.014252249151468277,
0.052249059081077576,
0.012911032885313034,
0.0063645439222455025,
0.00887464452534914,
0.0009381892159581184,
-0.02185763418674469,
-0.0263582244515419,
0.016619084402918816,
0.009881628677248955,
0.008075980469584465,
-0.03606747090816498,
-0.0039997403509914875,
-0.006867788732051849,
-0.007093111984431744,
-0.013361222110688686,
0.009593809023499489,
0.003643981646746397,
-0.024758702144026756,
-0.00995568372309208,
-0.0001337213907390833,
0.003214187454432249,
0.0015755489002913237,
-0.008967513218522072,
0.025672581046819687,
0.005507130641490221,
-0.010958978906273842,
-0.00956177432090044,
-0.016013124957680702,
0.07216015458106995,
0.014540651813149452,
-0.0038007141556590796,
-0.02336285635828972,
0.006970328278839588,
0.0024859141558408737,
-0.013649364933371544,
0.02303549274802208,
-0.022548643872141838,
-0.0014064488932490349,
0.013459257781505585,
-0.02278113178908825,
0.01377651747316122,
0.003113969461992383,
-0.003859779331833124,
-0.001869457890279591,
-0.0006997575983405113,
0.010153724811971188,
0.038760483264923096,
0.004611000884324312,
0.009687613695859909,
-0.008029023185372353,
0.008890559896826744,
0.013745562173426151,
-0.037060320377349854,
-0.01912796124815941,
-0.0015439875423908234,
-0.01183377020061016,
-0.008720330893993378,
0.003261709585785866,
0.0006229383870959282,
0.0037077646702528,
-0.005864768289029598,
-0.0000999129842966795,
0.02380533516407013,
0.009065176360309124,
0.03315935283899307,
-0.004943660460412502,
-0.012080634012818336,
-0.010622808709740639,
-0.002495604334399104,
-0.013043342158198357,
0.03207828104496002,
0.016313767060637474,
-0.018828153610229492,
-0.00036639394238591194,
-0.003304912708699703,
-0.008710711263120174,
0.005355203524231911,
0.007453270256519318,
-0.011707467027008533,
0.008862366899847984,
0.01526892650872469,
0.01350968424230814,
-0.009402690455317497,
-0.015265783295035362,
0.015858707949519157,
0.0006272732280194759,
0.01741516962647438,
-0.023314282298088074,
-0.010799212381243706,
0.00842998269945383,
0.013023894280195236,
-0.0000333727803081274,
0.02718750759959221,
-0.02383357472717762,
-0.013317421078681946,
0.002733400324359536,
0.015151008032262325,
-0.024966469034552574,
0.0006221556104719639,
0.0064616394229233265,
-0.004390571732074022,
0.013830350711941719,
-0.016017543151974678,
0.017489656805992126,
-0.012936167418956757,
-0.010829395614564419,
0.019708584994077682,
0.00785358902066946,
-0.012715550139546394,
-0.014131520874798298,
0.020911458879709244,
0.000024782551918178797,
0.005331381224095821,
-0.014141210354864597,
-0.038387954235076904,
-0.07518139481544495,
-0.01318396907299757,
-0.01298510655760765,
-0.005672474391758442,
0.019236048683524132,
0.03499871492385864,
-0.010439824312925339,
-0.0005049891769886017,
-0.008416658267378807,
-0.011635985225439072,
0.014401011168956757,
0.004361334722489119,
0.015056067146360874,
0.013469129800796509,
0.00871999654918909,
0.005677495151758194,
-0.026139792054891586,
-0.025485718622803688,
-0.018172066658735275,
-0.002557876519858837,
0.0020395703613758087,
0.015096992254257202,
-0.02808382734656334,
0.01039034128189087,
0.0036105215549468994,
-0.08103527128696442,
0.020671255886554718,
0.01623823679983616,
-0.0015871694777160883,
0.015991196036338806,
-0.03420453518629074,
0.016209131106734276,
0.002604700392112136,
-0.0070009995251894,
-0.015269806608557701,
-0.01744558848440647,
-0.014793280512094498,
-0.01492423377931118,
-0.011905660852789879,
-0.009493579156696796,
-0.005184398498386145,
0.013219105079770088,
0.009681865572929382,
0.013292966410517693,
0.00006488757207989693,
0.00691612996160984,
0.033184267580509186,
-0.008446495048701763,
-0.004601997788995504,
-0.008552821353077888,
-0.0206528902053833,
0.007509224116802216,
0.013263986445963383,
-0.024523189291357994,
0.009183518588542938,
0.008679520338773727,
-0.002034677192568779,
-0.004239451605826616,
-0.02100806124508381,
-0.004527266137301922,
-0.008684427477419376,
-0.014412861317396164,
-0.008165345527231693,
-0.021480873227119446,
0.0012014354579150677,
-0.0062862783670425415,
-0.01312168873846531,
0.0059439316391944885,
0.0184966791421175,
0.02151319570839405,
-0.02337670512497425,
0.008180632255971432,
-0.005155422259122133,
0.0122241685166955,
0.01001526229083538,
0.009981648996472359,
-0.02595713548362255,
-0.005607405677437782,
-0.007489681243896484,
-0.03720630705356598,
0.01393448282033205,
0.0011710760882124305,
-0.002368914894759655,
-0.014142611995339394,
0.0142397815361619,
-0.00306619331240654,
0.009136946871876717,
-0.01378369890153408,
0.07156261801719666,
-0.004913057200610638,
0.008049801923334599,
-0.039063408970832825,
0.0018774920608848333,
0.005320293828845024,
-0.044735997915267944,
-0.02205122448503971,
-0.02696182206273079,
-0.019900519400835037,
-0.002435785485431552,
0.0030727400444447994,
0.021967269480228424,
0.01334499754011631,
-0.020845431834459305,
-0.012403253465890884,
-0.006053027231246233,
-0.006395093630999327,
0.001032597734592855,
0.009434913285076618,
-0.0050279549323022366,
0.0027307653799653053,
-0.016211306676268578,
-0.023751426488161087,
0.01912236027419567,
-0.008170802146196365,
-0.02243606001138687,
0.0061686718836426735,
-0.03491926193237305,
0.011236237362027168,
-0.021170122548937798,
-0.0073356907814741135,
-0.0002850900636985898,
-0.019757069647312164,
0.015855470672249794,
0.0173018891364336,
-0.006533508189022541,
0.007047850638628006,
0.006377801764756441,
-0.021255288273096085,
0.013314943760633469,
-0.0012865766184404492,
-0.0039750332944095135,
-0.01692093536257744,
0.012290846556425095,
-0.023019272834062576,
0.004871551878750324,
0.005013605579733849,
-0.00583287887275219,
0.007969840429723263,
0.01077527180314064,
0.0030599019955843687,
-0.002626803470775485,
-0.008213125169277191,
0.00458015501499176,
0.048164065927267075,
0.002293539233505726,
0.014229720458388329,
0.008405606262385845,
0.015018564648926258,
-0.012470504269003868,
-0.004858384840190411,
0.0047556571662425995,
-0.019577298313379288,
0.014895985834300518,
-0.01895628683269024,
0.007357870694249868,
-0.023209402337670326,
-0.005080954171717167,
0.014224939048290253,
-0.02355733886361122,
0.015083343721926212,
0.005150645971298218,
0.011100335977971554,
0.011854170821607113,
0.006113845854997635,
0.03544630482792854,
-0.010149123147130013,
0.02022390253841877,
-0.0017033335752785206,
-0.0064102765172719955,
0.01749134249985218,
-0.007406044751405716,
-0.0198630690574646,
-0.018182383850216866,
-0.004493895452469587,
-0.0018547906074672937,
0.0050448160618543625,
0.004315625876188278,
0.011710058897733688,
-0.000528436154127121,
0.0028129443526268005,
0.0034362198784947395,
0.00956764630973339,
-0.00046953436685726047,
0.03504249081015587,
-0.011929539032280445,
0.011542869731783867,
-0.01677836664021015,
0.02262473665177822,
0.015844570472836494,
0.01687025837600231,
-0.008501207455992699,
0.006606561131775379,
-0.026166364550590515,
-0.0022138049826025963,
-0.0008597350097261369,
0.008260464295744896,
-0.008771565742790699,
-0.009686306118965149,
0.026495255529880524,
-0.005470640957355499,
0.00958497915416956,
0.0038698483258485794,
-0.00242965342476964,
0.02650037780404091,
0.0015908116474747658,
-0.010067911818623543,
0.010221562348306179,
-0.01314400602132082,
0.011039422824978828,
0.014467858709394932,
-0.00604036170989275,
0.03005562536418438,
-0.008299602195620537,
-0.005997090600430965,
-0.014516484923660755,
0.024312175810337067,
0.0044419411569833755,
-0.0225190669298172,
0.016756244003772736,
0.008578803390264511,
-0.0302377101033926,
0.004654310178011656,
-0.005493860226124525,
0.014607662335038185,
0.011356310918927193,
-0.010693912394344807,
0.001216912642121315,
-0.007299905177205801,
0.009680567309260368,
-0.012871073558926582,
0.00033567543141543865,
-0.006539498455822468,
0.007887543179094791,
-0.0014509666943922639,
0.01631133072078228,
-0.0021608059760183096,
0.013179993256926537,
-0.005676230415701866,
0.018573572859168053,
0.01923014596104622,
0.01372875552624464,
-0.007802109234035015,
-0.014889332465827465,
0.016644101589918137,
0.0038586300797760487,
0.029808295890688896,
-0.005227833054959774,
-0.015587691217660904,
0.00681510753929615,
-0.0218755342066288,
0.0029806476086378098,
-0.009440472349524498,
0.007354021072387695,
-0.00224179751239717,
-0.00425427732989192,
0.00003442075103521347,
-0.007707982324063778,
-0.007059788331389427,
0.03534960374236107,
-0.0323273204267025,
0.029700808227062225,
0.004453524947166443,
-0.011414499022066593,
-0.004827613942325115,
-0.02066921815276146,
-0.0024351165629923344,
0.002383848186582327,
-0.017706431448459625,
0.008167305029928684,
-0.009631780907511711,
0.011887701228260994,
-0.007582918740808964,
-0.002216086722910404,
-0.004460148513317108,
-0.0069469669833779335,
0.008050072938203812,
0.005765649490058422,
-0.00969383493065834,
-0.02556920424103737,
-0.018787648528814316,
0.0006527283112518489,
0.01653742603957653,
0.00009320024400949478,
0.001403912901878357,
0.015918411314487457,
0.0040398575365543365,
-0.007294573821127415,
0.0031747212633490562,
-0.021625781431794167,
0.0009577367454767227
] | [
-0.29203134775161743,
-0.3460482656955719,
0.26002204418182373,
-0.1091373935341835,
0.07041863352060318,
-0.02431470714509487,
0.19303537905216217,
-0.4028751850128174,
0.012568915262818336,
-0.4650823473930359,
0.10642722249031067,
0.3672294318675995,
-0.37752681970596313,
0.27727219462394714,
-0.12462121248245239,
0.7107126116752625,
0.21308791637420654,
0.0455000214278698,
0.10043668001890182,
-0.37237071990966797,
-0.44852322340011597,
-0.12909404933452606,
0.6485679745674133,
-0.3177720904350281,
0.32839247584342957,
0.08333656191825867,
0.6063014268875122,
0.09105180203914642,
0.2474084347486496,
-0.27491676807403564,
0.25988975167274475,
0.3782150149345398,
-0.3219214975833893,
-0.5273215174674988,
-0.5170989632606506,
-0.016768991947174072,
-0.4441264867782593,
0.10104542225599289,
-0.08664560317993164,
-0.03954587131738663,
-0.7362459301948547,
-0.036262720823287964,
-0.028077514842152596,
0.2964596748352051,
-0.06892114877700806,
-0.3946800231933594,
-1.4036970138549805,
0.2664814293384552,
-0.4660806953907013,
-0.17315605282783508,
-0.31999194622039795,
0.13881129026412964,
0.26990577578544617,
0.02569109946489334,
0.19447053968906403,
0.17303015291690826,
-0.8471097946166992,
-0.4042668044567108,
0.3441537916660309,
-0.48614993691444397,
-0.4046115577220917,
-0.12751078605651855,
-0.2572566866874695,
0.18980488181114197,
0.13408535718917847,
0.5276554822921753,
0.2631693184375763,
-0.5549091696739197,
-0.5437943339347839,
-0.1903173327445984,
0.11424466967582703,
-0.33204385638237,
-0.2512210011482239,
0.48608893156051636,
-0.019586604088544846,
-0.42739662528038025,
-0.4252382814884186,
-0.21582116186618805,
0.09237637370824814,
0.09361603856086731,
0.057066842913627625,
0.19949261844158173,
0.017447154968976974,
-0.12523983418941498,
0.5171021223068237,
0.36188164353370667,
-0.05339759588241577,
0.9214401841163635,
-0.5183886885643005,
0.16371317207813263,
0.027194147929549217,
-0.10902950167655945,
0.19928717613220215,
0.24430693686008453,
0.43172428011894226,
0.34285369515419006,
-0.32311728596687317,
-0.04250171780586243,
-0.4039476215839386,
0.748489260673523,
-0.34874629974365234,
0.17411527037620544,
0.0949653759598732,
-0.7250131964683533,
-0.17014123499393463,
-0.0768827572464943,
-0.3075485825538635,
-0.31072917580604553,
-0.8420007824897766,
0.24481353163719177,
-0.16071638464927673,
0.2425214946269989,
-0.32705777883529663,
-0.20747873187065125,
-0.06296480447053909,
0.12415636330842972,
0.532433807849884,
-0.12844175100326538,
-0.046903762966394424,
-0.01839524693787098,
0.06330638378858566,
1.9925469160079956,
-0.04336417466402054,
0.35041725635528564,
0.04073736071586609,
-0.27632060647010803,
0.30253201723098755,
0.03690295293927193,
-0.0463850274682045,
1.0346235036849976,
0.061035558581352234,
0.7257450222969055,
-0.18599793314933777,
0.09641407430171967,
-0.20932292938232422,
-0.27094754576683044,
-0.07327450066804886,
0.18722772598266602,
0.11150534451007843,
-0.10588528960943222,
-0.5595384836196899,
-0.14656546711921692,
0.08457492291927338,
-0.016819646582007408,
0.36473602056503296,
-0.11293290555477142,
-0.14565743505954742,
-0.034734636545181274,
0.03128502145409584,
-0.006589146330952644,
0.05078914761543274,
-0.28748926520347595,
-1.0488667488098145,
0.06834924221038818,
-0.18053016066551208,
0.34436240792274475,
0.05942245572805405,
-0.3685052692890167,
-0.038607459515333176,
0.3705512583255768,
0.44462940096855164,
0.051599740982055664,
-0.40005195140838623,
-0.16309872269630432,
0.1840258687734604,
-0.2938298285007477,
0.40625864267349243,
0.6793304681777954,
0.3141060173511505,
-0.6276576519012451,
-0.38806432485580444,
-0.417420357465744,
-0.09730613231658936,
-0.8032144904136658,
0.07542209327220917,
-0.09219616651535034,
0.2526889145374298,
-0.2406100481748581,
0.03389325365424156,
0.18877971172332764,
-0.7709903717041016,
-0.07996905595064163,
-0.1713244765996933,
-0.5606347322463989,
0.4542029798030853,
0.0664171576499939,
0.8503226041793823,
0.34990614652633667,
-0.07166260480880737,
0.24135087430477142,
-0.5740952491760254,
0.02076534554362297,
0.8833312392234802,
-0.3986866772174835,
1.3923311233520508,
0.17931737005710602,
0.06097641587257385,
1.6792526245117188,
0.3009966313838959,
0.04732414707541466,
-0.17001670598983765,
0.1525084227323532,
-0.01786375232040882,
-0.6017137169837952,
-0.7153761982917786,
-0.2687845528125763,
-0.10709870606660843,
-0.005167314317077398,
-0.028170552104711533,
0.09915979206562042,
0.4427501857280731,
-0.4580264687538147,
0.11841274797916412,
-0.39483919739723206,
0.3714751601219177,
-0.39354264736175537,
0.2962535321712494,
0.2912670075893402,
-0.38034766912460327,
-0.002157130278646946,
0.6539904475212097,
-0.6254315376281738,
0.9025518894195557,
0.9583727717399597,
-0.15706121921539307,
0.6032598614692688,
0.1817501336336136,
0.14614957571029663,
0.42352160811424255,
0.09744837880134583,
0.3779718279838562,
-0.7748393416404724,
0.3260461091995239,
-0.24645662307739258,
0.023963773623108864,
0.1000572219491005,
-0.20407094061374664,
0.04105508327484131,
-0.10299521684646606,
0.10864197462797165,
0.028152983635663986,
0.6321479678153992,
-0.5720764398574829,
-0.07972460240125656,
0.1085721105337143,
-0.49329689145088196,
-0.19521743059158325,
0.06079452112317085,
-0.49620798230171204,
-0.4416860044002533,
0.038032591342926025,
0.010773841291666031,
0.4230569899082184,
-0.2950221598148346,
0.09698206186294556,
-0.08892003446817398,
-0.2867034673690796,
-0.23748144507408142,
0.02564048022031784,
-0.44484513998031616,
-0.17114409804344177,
-0.020224962383508682,
0.021184494718909264,
0.17468000948429108,
0.1589692085981369,
-0.31141993403434753,
-0.5860925316810608,
-0.5661851167678833,
1.0868778228759766,
0.649086058139801,
1.223082184791565,
-0.003211646806448698,
-0.8402462005615234,
-0.24388718605041504,
0.36454445123672485,
-0.4341549873352051,
0.1212695986032486,
0.5173054933547974,
-0.38584065437316895,
-0.2678868770599365,
-0.018067603930830956,
0.41243690252304077,
0.8248661756515503,
-0.34783074259757996,
-0.7390075922012329,
-0.076256163418293,
-0.037656672298908234,
-0.2814258933067322,
-0.3478586673736572,
-0.2115863561630249,
-0.21704807877540588,
0.14188911020755768,
-0.5216707587242126,
-0.004289304371923208,
0.2575727105140686,
0.06590937823057175,
-0.21236799657344818,
0.25614485144615173,
0.6216737031936646,
-0.2272292673587799,
-0.41504019498825073,
0.226388618350029,
-0.19778449833393097,
-0.22597694396972656,
-0.2813877463340759,
-0.0999879464507103,
-0.04458247870206833,
0.112730473279953,
-5.869692325592041,
0.051509641110897064,
-0.022958334535360336,
0.029545819386839867,
0.13051557540893555,
-0.28469008207321167,
1.0183523893356323,
-0.29392868280410767,
0.6045165061950684,
0.16645348072052002,
0.20571696758270264,
0.557526707649231,
0.1247597187757492,
-0.46296799182891846,
-0.14676429331302643,
0.08417925238609314,
-0.2245120108127594,
-0.13265997171401978,
0.8869682550430298,
0.003253682516515255,
0.6026819944381714,
-0.47903934121131897,
0.04070137441158295,
0.453557550907135,
-0.05620997026562691,
-0.17230907082557678,
-0.9724579453468323,
0.2790084779262543,
-0.16220369935035706,
-0.22891299426555634,
0.21222767233848572,
-0.49265098571777344,
0.016613565385341644,
-0.3416299819946289,
0.16422070562839508,
-0.09928012639284134,
0.2861337661743164,
0.17446668446063995,
-0.06236429512500763,
-0.5766101479530334,
0.6689337491989136,
0.27300065755844116,
-0.11078069359064102,
-0.15105950832366943,
0.030429568141698837,
-0.24039797484874725,
0.05791657045483589,
0.22193080186843872,
0.07811389863491058,
0.7036422491073608,
-0.03209724649786949,
-0.24000020325183868,
0.45385685563087463,
0.4249943494796753,
0.1266060173511505,
-0.20659436285495758,
0.026683229953050613,
0.21201756596565247,
-0.07106228917837143,
0.3539377748966217,
-0.3153931200504303,
-0.17040687799453735,
-0.35960763692855835,
-0.5511494874954224,
-0.008271411992609501,
0.5004414916038513,
-0.26848968863487244,
-0.2799415588378906,
0.016553187742829323,
0.029710810631513596,
-0.3565819263458252,
0.33716148138046265,
0.1393231898546219,
-0.36803457140922546,
0.668624222278595,
-0.1534336358308792,
0.13236424326896667,
-0.018910622224211693,
-0.05733123794198036,
0.0923558920621872,
-0.653252899646759,
-0.44691675901412964,
0.019197873771190643,
-0.17313608527183533,
0.775367796421051,
-0.32141050696372986,
-0.28568196296691895,
-0.04662669450044632,
-0.2763995826244354,
0.2734372913837433,
0.4214743375778198,
-0.22549781203269958,
0.290606826543808,
0.6562870144844055,
0.35687652230262756,
0.26667311787605286,
0.36715513467788696,
0.7064319849014282,
0.5233880281448364,
0.12074483186006546,
0.5953372716903687,
0.14352074265480042,
-0.2224445343017578,
-1.0169316530227661,
0.35113075375556946,
0.22952039539813995,
-0.6017619967460632,
0.19913043081760406,
0.5235271453857422,
-0.6404834389686584,
0.000055992091802181676,
0.13250146806240082,
-0.4787253141403198,
0.12530013918876648,
0.5569322109222412,
-0.03615893796086311,
-0.18832078576087952,
0.010149023495614529,
0.6219280958175659,
-0.32753923535346985,
-0.03091222234070301,
0.4537855386734009,
-0.3713885545730591,
0.5912582278251648,
0.0886622816324234,
-0.6315452456474304,
0.4287053048610687,
0.9873576164245605,
-0.46951183676719666,
-0.39800354838371277,
0.32961931824684143,
0.40246036648750305,
-0.6430293321609497,
-0.6647207140922546,
0.3720063865184784,
-0.5029979348182678,
-0.3528977632522583,
0.3556915521621704,
-0.025066211819648743,
-0.20104752480983734,
0.13146214187145233,
-0.38613465428352356,
-0.031906962394714355,
0.0356304831802845,
0.19069591164588928,
0.160784512758255,
0.37520289421081543,
0.3481367230415344,
-0.44766077399253845,
-0.3194243609905243,
-0.21848508715629578,
-0.23181061446666718,
-0.01663881167769432,
-0.31926199793815613,
0.1764908730983734,
0.16966448724269867,
0.5787460207939148,
0.17516987025737762,
0.2187805026769638,
-0.40016698837280273,
0.06851187348365784,
0.3531959652900696,
-0.7882943153381348,
0.1578606516122818,
-0.5342406034469604,
-0.30590134859085083,
-0.21244050562381744,
-0.024685049429535866,
-0.026415236294269562,
0.3994859755039215,
-0.4811183214187622,
-0.36949726939201355,
0.1637316197156906,
-0.25199094414711,
0.05714425817131996,
-0.5027153491973877,
-0.2511741816997528,
-0.016719376668334007,
-0.3954804241657257,
-0.039855118840932846,
0.33544793725013733,
-0.8825951814651489,
-0.04270564392209053,
0.39044228196144104,
0.5882981419563293,
0.0007627260638400912,
-0.1311236172914505,
-0.12019677460193634,
-0.3474641740322113,
-0.6371548771858215,
-0.33368614315986633,
0.2910926342010498,
0.2704685926437378,
-0.39127299189567566,
0.10725576430559158,
-0.06949160248041153,
0.1740349680185318,
0.20030541718006134,
0.03933112323284149,
-0.5605270266532898,
-0.024940738454461098,
0.3723840117454529,
-0.2349347025156021,
0.1809314340353012,
0.34506338834762573,
-0.029960669577121735,
-0.2088691145181656,
0.43987908959388733,
-0.1358213722705841,
-0.24938635528087616,
-0.20685262978076935,
-0.6157124638557434,
0.606661856174469,
0.5391507744789124,
-0.18668879568576813,
-0.07430309802293777,
0.11197160929441452,
-0.028241533786058426,
-0.01472854521125555,
0.18967513740062714,
0.3960708677768707,
-0.6302499771118164,
0.20826491713523865,
0.1227082684636116,
-0.8200022578239441,
0.17799125611782074,
0.5538397431373596,
-1.120358943939209,
0.34472447633743286,
0.15415681898593903,
-0.07714768499135971,
-0.2914432883262634,
0.09175346791744232,
0.19963152706623077,
-0.21897514164447784,
-0.40037694573402405,
-0.5146825909614563,
0.4300486743450165,
-0.12635792791843414,
0.42822811007499695,
0.1421072781085968,
0.47525808215141296,
-0.5372755527496338,
0.0419892854988575,
-0.1880078911781311,
0.4294321835041046,
0.21305042505264282,
-0.08704018592834473,
-0.24751237034797668,
0.20124781131744385,
0.19821716845035553,
-0.029454560950398445,
0.053602978587150574,
0.48415064811706543,
1.1056338548660278,
0.11846950650215149,
-0.021727057173848152,
-0.4098808765411377,
-0.5438826680183411,
0.3504505455493927,
-0.4252389967441559,
0.484135240316391,
-0.13910797238349915,
0.050042156130075455,
0.4175514280796051,
0.1683284044265747,
0.09324724972248077,
-0.9649099111557007,
0.42280325293540955,
0.21619081497192383,
-0.3535783886909485,
-0.34567520022392273,
0.21881338953971863,
0.43732360005378723,
-0.3647015690803528,
0.08099458366632462,
0.009310788474977016,
0.38888823986053467,
0.0176446083933115,
0.5520655512809753,
-0.34390750527381897,
-0.711588978767395,
0.4251950681209564,
-0.5592827796936035,
0.03010728396475315,
-0.3838817775249481,
0.2798759937286377,
-0.47174587845802307,
0.5109676122665405,
-0.03396281227469444,
-0.15821759402751923,
-0.10690660774707794,
-0.8449856638908386,
-0.4123757779598236,
-0.3858034312725067,
0.4882968068122864,
0.04549669846892357,
0.03163323551416397,
-0.18576613068580627,
-0.11352940648794174,
-0.5371173024177551,
0.4261048138141632,
0.7657008767127991,
-0.4902779161930084,
-0.21580640971660614,
0.4528094530105591,
0.25701776146888733,
0.3728126585483551,
-0.29682108759880066,
-0.1787337064743042,
-0.488523006439209,
-0.03676754608750343,
0.4959164559841156,
0.24122999608516693,
-0.6315619349479675,
0.03780285269021988,
-0.27431657910346985,
0.09972978383302689,
0.056156471371650696,
0.2002289891242981,
-0.0344640351831913,
-0.056901492178440094,
0.39163124561309814,
-0.03291742503643036,
-0.6121290326118469,
0.47216883301734924,
0.2280750274658203,
-0.16803349554538727,
-0.2761278748512268,
0.5707488656044006,
0.39191174507141113,
0.4127655029296875,
-0.3229324519634247,
0.6613652110099792,
0.3677619993686676,
0.16084596514701843,
0.2988618314266205,
-0.31834763288497925,
-0.1425849348306656,
-0.03935595974326134,
0.6790854334831238,
0.08752184361219406,
-0.40357705950737,
0.08828035742044449,
0.5156914591789246,
0.02770107239484787,
0.49119675159454346,
0.40742626786231995,
-0.30355751514434814,
0.3827686905860901,
-0.03457866981625557,
-0.029681935906410217,
-0.4590556025505066,
0.3667815327644348,
-0.3295366168022156,
-0.1668066829442978,
0.8265526294708252,
-0.40824660658836365,
-0.33346065878868103,
0.04134153202176094,
-0.1092483401298523,
0.21151705086231232,
0.008642196655273438,
0.8516055345535278,
-0.16653776168823242,
-0.28211709856987,
0.5224125385284424,
0.14998890459537506,
0.4530010521411896,
0.052322518080472946,
-0.024905797094106674,
-0.06062166392803192,
-0.4163125157356262,
0.22653351724147797,
0.26610496640205383,
-0.17387615144252777,
-0.2897326350212097,
-0.26212623715400696,
0.13944599032402039,
0.39560166001319885,
-0.22625550627708435,
0.19031402468681335,
-0.016705689951777458,
-0.6572686433792114,
-0.5095292329788208,
-0.16348402202129364,
-0.47427406907081604,
-0.3216424584388733,
0.16309410333633423,
0.05795179307460785,
0.4393131136894226,
-0.6748958826065063,
-0.050426848232746124,
0.13876397907733917,
0.1172652617096901,
-0.1657695174217224,
0.010348931886255741,
0.32638096809387207,
0.10577148199081421,
0.6614661812782288,
0.07960724085569382,
0.595862090587616,
-0.031886812299489975,
0.6185960173606873,
-0.47263821959495544,
0.3747559189796448,
-0.3216935396194458,
-0.19729802012443542,
-0.449969083070755,
-0.3769820034503937,
1.1529422998428345,
0.5396687984466553,
-0.1710646152496338,
-0.17957168817520142,
0.11022073030471802,
0.2986699044704437,
-0.2711013853549957,
-0.4271973967552185,
0.4183502197265625,
-0.5482990145683289,
-0.08293239027261734,
-0.3801412582397461,
0.5591254830360413,
-0.003790750401094556,
-0.35787737369537354,
0.0738358348608017,
0.2847623825073242,
0.27699190378189087,
-0.46352240443229675,
0.010287669487297535,
0.1570603996515274,
0.299614816904068,
-0.4616755247116089,
-0.1052185595035553,
-0.3392631709575653,
0.21323752403259277,
-0.33489423990249634,
-0.09607847034931183,
0.09302918612957001,
-0.16823548078536987,
0.057703036814928055,
0.06115942820906639,
0.07740763574838638,
0.017405249178409576,
0.18061722815036774,
-0.05765257775783539,
-0.1353793442249298,
-0.7155693769454956,
-0.7299707531929016,
0.3376893103122711,
0.09471698105335236,
-0.44957858324050903,
0.029815200716257095,
0.18491774797439575,
0.10818701237440109,
-0.0227272380143404,
0.17352893948554993,
-0.5259930491447449,
-0.38230761885643005,
-0.2405598759651184
] |
BACKGROUND: Rift Valley fever virus (RVFV), a member of the genus Phlebovirus within the family Bunyaviridae, is a negative-stranded RNA virus with a tripartite genome. RVFV is transmitted by mosquitoes and causes fever and severe hemorrhagic illness among humans, while in livestock it causes fever and high abortion rates. METHODOLOGY/PRINCIPAL FINDINGS: Sequence analysis showed that a wild-type RVFV ZH501 preparation consisted of two major viral subpopulations, with a single nucleotide heterogeneity at nucleotide 847 of M segment (M847); one had a G residue at M847 encoding glycine in a major viral envelope Gn protein, while the other carried A residue encoding glutamic acid at the corresponding site. Two ZH501-derived viruses, rZH501-M847-G and rZH501-M847-A, carried identical genomic sequences, except that the former and the latter had G and A, respectively, at M847 were recovered by using a reverse genetics system. Intraperitoneal inoculation of rZH501-M847-A into mice caused a rapid and efficient viral accumulation in the sera, livers, spleens, kidneys and brains, and killed most of the mice within 8 days, whereas rZH501-M847-G caused low viremia titers, did not replicate as efficiently as did rZH501-M847-A in these organs, and had attenuated virulence to mice. Remarkably, as early as 2 days postinfection with rZH501-M847-G, the viruses carrying A at M847 emerged and became the major virus population thereafter, while replicating viruses retained the input A residue at M847 in rZH501-M847-A-infected mice. CONCLUSIONS/SIGNIFICANCE: These data demonstrated that the single nucleotide substitution in the Gn protein substantially affected the RVFV mouse virulence and that a virus population carrying the virulent viral genotype quickly emerged and became the major viral population within a few days in mice that were inoculated with the attenuated virus. | [
-0.02777370996773243,
0.01748392917215824,
0.006792791187763214,
0.019895868375897408,
-0.023593610152602196,
-0.008687259629368782,
0.009873433038592339,
0.047965891659259796,
-0.012965155765414238,
-0.001019492745399475,
-0.01201282162219286,
0.020971106365323067,
-0.023294150829315186,
0.021570658311247826,
0.004411966074258089,
-0.0008610258810222149,
-0.005387604236602783,
0.018745560199022293,
0.008919047191739082,
0.007496345322579145,
0.02373727597296238,
-0.006381917279213667,
0.009403843432664871,
0.002140593249350786,
-0.013031122274696827,
-0.0011924456339329481,
-0.003380243666470051,
-0.013566387817263603,
0.022450298070907593,
0.005695222411304712,
0.04442761093378067,
0.01811300963163376,
-0.013599324971437454,
-0.012951944954693317,
0.008438125252723694,
0.013972584158182144,
-0.005835060961544514,
0.009867704473435879,
0.011565789580345154,
-0.004151551052927971,
0.011602653190493584,
-0.007334298919886351,
0.008023134432733059,
-0.03288676217198372,
-0.0078123463317751884,
-0.024350605905056,
-0.0018150784308090806,
0.0011366577818989754,
-0.02614547498524189,
0.002610950730741024,
-0.017972949892282486,
0.006991885136812925,
-0.006093808449804783,
0.030705377459526062,
-0.005937118083238602,
-0.015090785920619965,
0.018234506249427795,
0.02467339113354683,
-0.0018749265000224113,
0.017965352162718773,
0.024732250720262527,
-0.012550756335258484,
-0.027653805911540985,
-0.006483403965830803,
0.008467055857181549,
-0.06731018424034119,
0.009567649103701115,
0.008014301769435406,
0.012983402237296104,
-0.012165114283561707,
0.0075441948138177395,
0.005005331709980965,
0.03198109194636345,
-0.016814151778817177,
-0.03035130351781845,
0.0010920949280261993,
-0.008044282905757427,
0.022806838154792786,
-0.02234761416912079,
0.011626046150922775,
0.04530823603272438,
0.0065717073157429695,
0.009304074570536613,
0.019259829074144363,
-0.014354546554386616,
0.022965677082538605,
-0.021704914048314095,
-0.03251620754599571,
-0.024651508778333664,
-0.006311454344540834,
-0.0018498154822736979,
-0.021746337413787842,
-0.02496572956442833,
0.007849592715501785,
-0.0313546396791935,
0.015124551951885223,
-0.011551166884601116,
-0.04662211984395981,
0.03063134476542473,
-0.00852019339799881,
-0.0050620827823877335,
0.010641125030815601,
0.010129589587450027,
0.0004651423078030348,
-0.0070931920781731606,
0.0041221375577151775,
-0.0005351901054382324,
-0.007976202294230461,
0.02680356800556183,
0.01604948565363884,
-0.023155048489570618,
-0.01741119660437107,
0.03755267709493637,
0.03366159275174141,
-0.0006436523981392384,
-0.0057348934933543205,
-0.0015208751428872347,
0.023520270362496376,
0.001942315837368369,
0.01457250490784645,
-0.0025556101463735104,
-0.0022248185705393553,
0.003750802017748356,
-0.0017887796275317669,
0.010846849530935287,
-0.027933068573474884,
0.017396535724401474,
-0.007352607324719429,
0.020249739289283752,
-0.0015082560712471604,
-0.007292835973203182,
0.017011500895023346,
-0.04247108846902847,
-0.025552745908498764,
0.01076370757073164,
-0.00396086648106575,
0.02153346687555313,
-0.0065242392010986805,
-0.011629578657448292,
-0.00878906063735485,
-0.025994395837187767,
0.005262176040560007,
0.008670594543218613,
0.018436353653669357,
-0.00006308313459157944,
0.010570209473371506,
-0.005063808988779783,
0.0155235156416893,
0.04823046922683716,
-0.007414037361741066,
0.0016718371771275997,
-0.01091352105140686,
-0.012245206162333488,
0.001185462810099125,
-0.0074877431616187096,
0.008340864442288876,
-0.019955873489379883,
-0.008514104411005974,
0.0071771168150007725,
0.024555541574954987,
0.0008696039440110326,
0.017984379082918167,
0.007718980312347412,
0.00839756615459919,
-0.01778680458664894,
0.001100153662264347,
0.004989827983081341,
-0.016924679279327393,
-0.001918655470944941,
0.009645868092775345,
0.0010324721224606037,
0.0063803717494010925,
0.012064933776855469,
0.012034827843308449,
-0.009178167209029198,
-0.0013440651819109917,
-0.00706925755366683,
0.006563484203070402,
-0.015156373381614685,
0.06653216481208801,
0.02038929983973503,
0.002409420907497406,
-0.03169636428356171,
-0.01460106298327446,
0.03307526558637619,
-0.01736304722726345,
0.008931191638112068,
-0.01852620393037796,
0.008342279121279716,
-0.00821777991950512,
0.0037655222695320845,
0.02557547762989998,
-0.01177101582288742,
0.00492874113842845,
0.02073122188448906,
0.00399641040712595,
0.023830190300941467,
0.0152279669418931,
0.017827384173870087,
0.0010504373349249363,
0.00663596298545599,
-0.00982335302978754,
0.016931043937802315,
0.000790654681622982,
-0.02936561033129692,
-0.0025396307464689016,
0.005014713387936354,
0.015345683321356773,
-0.025750262662768364,
-0.0432482473552227,
0.007734701503068209,
0.006370353978127241,
0.01243999321013689,
0.0003096773289144039,
0.02051209658384323,
0.002198929665610194,
-0.0061338976956903934,
0.0015812218189239502,
0.014319876208901405,
-0.009946055710315704,
-0.01628495752811432,
-0.005241435952484608,
-0.031225314363837242,
-0.01164532545953989,
-0.004733478184789419,
0.02377723902463913,
0.00984857976436615,
0.012277575209736824,
-0.005886906757950783,
0.005205243825912476,
0.0012790248729288578,
-0.036701127886772156,
-0.009657553397119045,
0.017217308282852173,
0.02200663648545742,
-0.018679924309253693,
0.015290318056941032,
-0.003275766735896468,
0.009211561642587185,
-0.010762471705675125,
0.001331033417955041,
0.025421898812055588,
-0.007434610277414322,
-0.0012677435297518969,
-0.001657458022236824,
0.00942272786051035,
0.0028427797369658947,
0.014890806749463081,
-0.04610167443752289,
-0.04189376160502434,
0.007795130833983421,
0.036359742283821106,
0.021610021591186523,
-0.029868202283978462,
0.03026602603495121,
0.011396266520023346,
0.03833944723010063,
0.0012800160329788923,
0.023478832095861435,
0.0178268663585186,
0.015019426122307777,
0.00538327032700181,
-0.012935491278767586,
-0.040582075715065,
-0.018928760662674904,
0.030913716182112694,
-0.01361742801964283,
0.0019244770519435406,
-0.0027640757616609335,
-0.027056438848376274,
0.010484419763088226,
-0.008084474131464958,
-0.002516372362151742,
-0.08207974582910538,
-0.00799928791821003,
-0.00593325961381197,
-0.04278621822595596,
0.007574434392154217,
0.0047370754182338715,
-0.0024770875461399555,
0.011517895385622978,
-0.004488273989409208,
-0.000575970858335495,
0.013294396921992302,
0.027670182287693024,
-0.008846578188240528,
-0.0066230883821845055,
-0.004822077229619026,
-0.01552409678697586,
0.013442146591842175,
0.008281676098704338,
-0.041619788855314255,
-0.030404001474380493,
0.013005122542381287,
0.01827917993068695,
0.056627221405506134,
0.0006098651792854071,
-0.0063993195071816444,
0.0237477608025074,
0.01541822962462902,
0.019607750698924065,
-0.03453359007835388,
-0.009573234245181084,
0.02011280693113804,
0.0005220347084105015,
0.026537299156188965,
0.027556132525205612,
0.032855283468961716,
0.009251427836716175,
0.008528647944331169,
-0.021094076335430145,
-0.011999005451798439,
0.020832544192671776,
-0.011694036424160004,
0.01650787517428398,
0.01022074744105339,
-0.005803863983601332,
0.0022625052370131016,
0.025059740990400314,
-0.004090888425707817,
0.05161062628030777,
0.014351150020956993,
-0.012506352737545967,
-0.02152230590581894,
-0.009652817621827126,
0.04006268084049225,
0.005875790491700172,
-0.0056083304807543755,
0.0022756559774279594,
-0.03757452592253685,
-0.00263823545537889,
-0.011982286348938942,
-0.01949196308851242,
-0.022194907069206238,
0.013750840909779072,
0.014255577698349953,
-0.0019680019468069077,
-0.03318726643919945,
0.020315302535891533,
0.02023475244641304,
0.005616412963718176,
-0.010346543043851852,
0.02216080203652382,
0.013918992131948471,
0.014270221814513206,
-0.0194234699010849,
-0.011348445899784565,
0.006134367547929287,
0.008608990348875523,
-0.01005821954458952,
-0.005269533488899469,
-0.0017991454806178808,
0.002253670711070299,
-0.030384648591279984,
0.004116489551961422,
-0.012795452028512955,
0.01907159574329853,
-0.025148721411824226,
0.001325354678556323,
0.006330380216240883,
0.014480150304734707,
0.009446478448808193,
-0.008813699707388878,
0.014808396808803082,
-0.007384524680674076,
-0.03502129018306732,
0.016591493040323257,
-0.03829338774085045,
-0.0010063544614240527,
0.014071568846702576,
0.029880842193961143,
-0.0006567783420905471,
0.00861116498708725,
-0.01331699825823307,
-0.0144076282158494,
-0.009250473231077194,
-0.007221481762826443,
-0.006905798334628344,
0.017896555364131927,
-0.005387400276958942,
0.011684691533446312,
0.0030339080840349197,
0.0009453966049477458,
0.02026377245783806,
-0.025715386494994164,
-0.011989571154117584,
-0.01045262161642313,
0.010559458285570145,
-0.00757334940135479,
0.007985939271748066,
-0.025334078818559647,
0.07214304804801941,
-0.016253162175416946,
0.019895393401384354,
0.001881529577076435,
0.002227135468274355,
-0.003900866722688079,
-0.0027817010413855314,
-0.00672440230846405,
-0.006881224922835827,
0.004799430258572102,
0.01098596304655075,
-0.023307159543037415,
-0.0036952546797692776,
0.0072430893778800964,
0.019487502053380013,
0.0041152616031467915,
0.026587653905153275,
-0.04900037497282028,
0.005065825302153826,
0.018513178452849388,
0.011468786746263504,
0.0052607255056500435,
-0.0046879299916327,
-0.0065053533762693405,
0.014408539980649948,
0.03526175394654274,
-0.0006293510086834431,
-0.014290355145931244,
-0.004654242657124996,
0.00812453217804432,
0.0015634391456842422,
-0.02923910692334175,
-0.007291086483746767,
-0.01575695537030697,
0.022966301068663597,
-0.019596004858613014,
-0.03316979855298996,
0.011174982413649559,
0.014201723039150238,
-0.010853559710085392,
-0.020497236400842667,
-0.013923721387982368,
0.019504975527524948,
0.00761386938393116,
0.02313697338104248,
-0.019834641367197037,
-0.010255618952214718,
-0.013440658338367939,
-0.02091880887746811,
-0.01725526712834835,
0.02052343636751175,
-0.005131730809807777,
0.010252397507429123,
-0.005036945454776287,
-0.003393695689737797,
0.009287876076996326,
0.02001645788550377,
-0.0025544287636876106,
0.0020388304255902767,
-0.02610405534505844,
0.031643204391002655,
0.001732801552861929,
-0.0027234498411417007,
0.005568985361605883,
0.027126949280500412,
-0.01988227479159832,
-0.009319807402789593,
0.00011039100354537368,
0.007261972874403,
-0.014490079134702682,
0.009008953347802162,
-0.01958434469997883,
-0.02323256991803646,
-0.015273242257535458,
-0.010436267592012882,
-0.015403952449560165,
-0.025810888037085533,
0.013014871627092361,
0.007312189321964979,
0.0007302373414859176,
0.020596902817487717,
0.007139340974390507,
0.010281947441399097,
-0.015239737927913666,
0.01069108210504055,
-0.0160677433013916,
-0.019119249656796455,
-0.07446704059839249,
-0.01960160955786705,
0.01321147009730339,
-0.004572062287479639,
0.025208400562405586,
0.02228829264640808,
-0.007929148152470589,
-0.037246547639369965,
-0.027000026777386665,
-0.00950064230710268,
0.01780761405825615,
0.0036343149840831757,
0.0017446011770516634,
-0.003973389510065317,
0.012843425385653973,
0.02437470480799675,
-0.005095792934298515,
-0.005481093656271696,
-0.01666605845093727,
0.01700773276388645,
0.023416191339492798,
0.01002003625035286,
-0.027302607893943787,
-0.010321659967303276,
0.004022299312055111,
-0.08124157041311264,
0.006302255671471357,
0.017482904717326164,
-0.027947859838604927,
0.007025373168289661,
-0.01883678138256073,
0.027811653912067413,
-0.018745094537734985,
0.01184972282499075,
-0.013478219509124756,
0.00010648928582668304,
-0.028286544606089592,
0.014685273170471191,
-0.018642092123627663,
0.021415965631604195,
-0.015531016513705254,
0.010442271828651428,
0.011532052420079708,
0.020150862634181976,
0.010470099747180939,
-0.012038816697895527,
0.023513097316026688,
-0.008533083833754063,
-0.027265515178442,
-0.008623207919299603,
-0.019788384437561035,
-0.05215800553560257,
0.010870729573071003,
-0.024107638746500015,
-0.012650152668356895,
-0.0006469665095210075,
0.008244908414781094,
-0.0025304837618023157,
-0.044313885271549225,
0.02908296324312687,
-0.01877715438604355,
0.03379809111356735,
0.003557194024324417,
-0.010736415162682533,
0.00426388718187809,
-0.0027985768392682076,
-0.027938243001699448,
0.008164872415363789,
0.024123236536979675,
-0.008694709278643131,
-0.03508887067437172,
0.008807945996522903,
-0.011460456065833569,
0.014766988344490528,
-0.033058471977710724,
-0.0007999008521437645,
-0.053266193717718124,
-0.005867193453013897,
-0.014286897145211697,
0.011212164536118507,
-0.0199933722615242,
-0.003724215319380164,
0.006138935685157776,
0.00006576976738870144,
0.004887997172772884,
-0.005876939278095961,
0.016475046053528786,
0.02417365089058876,
0.07200775295495987,
-0.021534673869609833,
-0.0011162224691361189,
-0.01093209907412529,
-0.001648327219299972,
0.01004001870751381,
-0.035486213862895966,
0.016762660816311836,
-0.0034658079966902733,
-0.03337540477514267,
0.00018231943249702454,
-0.009404413402080536,
-0.03710750490427017,
0.00772899342700839,
0.013004735112190247,
-0.0026780429761856794,
-0.005105213727802038,
-0.006852034945040941,
-0.009459881111979485,
-0.020435811951756477,
-0.024851664900779724,
-0.026539746671915054,
-0.020092347636818886,
-0.02340349182486534,
0.007620468270033598,
0.003639581147581339,
-0.02879628911614418,
0.002942408435046673,
-0.0061880722641944885,
0.014804423786699772,
-0.0059137893840670586,
0.015222661197185516,
0.0036204932257533073,
-0.017284780740737915,
0.0007519354112446308,
0.0034734271466732025,
-0.027694132179021835,
0.01313109789043665,
-0.007116696331650019,
-0.003355950117111206,
-0.013321003876626492,
0.012994157150387764,
-0.0075942836701869965,
-0.016837798058986664,
0.010588492266833782,
-0.007587490603327751,
0.0037447852082550526,
0.016025876626372337,
0.017394565045833588,
0.021064503118395805,
-0.008702866733074188,
0.005423073656857014,
0.03192166984081268,
-0.0019167209975421429,
0.01627064310014248,
-0.016189932823181152,
-0.023930612951517105,
0.005803755484521389,
0.0006048646755516529,
-0.01615896075963974,
-0.006185321137309074,
-0.015906333923339844,
0.021688353270292282,
-0.02024868130683899,
-0.010837257839739323,
-0.013095065020024776,
0.007406299933791161,
-0.02032308652997017,
-0.04985632747411728,
0.013403047807514668,
-0.0028439280577003956,
-0.0007653555367141962,
0.009578565135598183,
0.006780220661312342,
0.010448429733514786,
0.013421658426523209,
0.03312874957919121,
-0.01475180871784687,
0.021750397980213165,
0.011075658723711967,
-0.008333642035722733,
-0.045488305389881134,
0.010436373762786388,
-0.002793015679344535,
-0.013311787508428097,
0.007521485909819603,
0.012705348432064056,
-0.015584247186779976,
-0.00535567058250308,
0.0014102836139500141,
0.000395764596760273,
0.015882257372140884,
0.01105036772787571,
-0.017742309719324112,
0.01097249798476696,
0.03395117446780205,
-0.0010410802206024528,
0.007944458164274693,
0.005709443707019091,
-0.006340986583381891,
0.016947481781244278,
-0.021370233967900276,
-0.008471054024994373,
0.009340943768620491,
0.002833899576216936,
-0.003473411314189434,
-0.004990953952074051,
0.028469916433095932,
-0.005598067305982113,
-0.0061525944620370865,
0.03344842791557312,
0.014034661464393139,
0.03138016536831856,
-0.003361174138262868,
0.00885266624391079,
0.011960690841078758,
-0.017111659049987793,
0.022587327286601067,
0.01916048675775528,
-0.014932043850421906,
0.02019812911748886,
-0.014368552714586258,
0.029112745076417923,
0.044434837996959686,
-0.03411519154906273,
-0.0014828458661213517,
-0.01078043319284916,
-0.012988054193556309,
-0.01648896560072899,
-0.016774790361523628,
0.016894260421395302,
-0.009428326971828938,
-0.01095554605126381,
0.02087114378809929,
-0.013119898736476898,
0.006832343526184559,
-0.00048160459846258163,
-0.01865551434457302,
-0.01224653422832489,
-0.02481134980916977,
-0.00741000659763813,
-0.02255837805569172,
0.006894610356539488,
-0.014229025691747665,
0.008495446294546127,
-0.007610759697854519,
0.03073243424296379,
0.013471479527652264,
0.012868687510490417,
0.006700621917843819,
0.003129387041553855,
-0.00511202123016119,
-0.026720445603132248,
-0.005992846563458443,
0.01648925431072712,
-0.0038323344197124243,
0.010191953741014004,
-0.002272594254463911,
-0.001315005123615265,
0.014765352942049503,
0.006990582216531038,
0.018606072291731834,
0.016550716012716293,
0.00673216488212347,
0.006878514774143696,
0.02582438848912716,
0.02439596876502037,
0.012296408414840698,
-0.015098925679922104,
-0.0071275727823376656,
-0.014894181862473488,
-0.02038992941379547,
0.008383339270949364,
-0.013011055067181587,
-0.010920793749392033,
-0.00495016947388649,
0.003158471779897809,
-0.010657115839421749,
-0.02293788455426693,
0.008671588264405727,
0.006840689107775688,
-0.02647463232278824,
-0.009255555458366871,
-0.010570928454399109,
0.0017818365013226867,
0.015725020319223404,
-0.00022421660833060741,
0.02572472393512726,
-0.013400116004049778,
0.0023004983086138964,
-0.025795742869377136,
0.003584788180887699,
0.0024145636707544327,
0.018453704193234444,
0.02256547287106514,
0.00464026490226388,
-0.017597604542970657,
0.009491957724094391,
0.004017113707959652,
0.01001670490950346,
0.007121889386326075,
-0.004084850661456585
] | [
0.24158009886741638,
0.142564594745636,
-0.02944076806306839,
-0.023952029645442963,
0.028898052871227264,
0.22527658939361572,
0.40964475274086,
0.10051125288009644,
-0.18128016591072083,
-0.5035718083381653,
0.04632716625928879,
-0.24928277730941772,
-0.43700236082077026,
0.4629018306732178,
-0.08422902971506119,
0.6679953932762146,
0.15181909501552582,
0.3739466965198517,
-0.6658220887184143,
-0.1896255910396576,
-0.12284041196107864,
-0.38339969515800476,
0.043105438351631165,
0.4073229730129242,
-0.1426459401845932,
0.01808452047407627,
0.8012819290161133,
-0.027778655290603638,
0.7773478627204895,
-0.534817636013031,
0.3185493052005768,
0.4257347285747528,
0.4255498945713043,
-0.3747659921646118,
-0.008153846487402916,
-0.3355579078197479,
-0.5993769764900208,
0.25079596042633057,
0.29650378227233887,
-0.05878286436200142,
-0.04114104062318802,
-0.6696423888206482,
-0.3765198588371277,
0.02287694811820984,
0.15530061721801758,
-1.0014183521270752,
-0.7887229919433594,
1.2265689373016357,
-0.5179510712623596,
-0.04916081577539444,
-0.24261367321014404,
0.34007754921913147,
0.05263301357626915,
-0.027535438537597656,
0.39545270800590515,
0.2833184599876404,
-0.5285806655883789,
-0.2851063907146454,
0.35332241654396057,
-0.6676800847053528,
0.07413727045059204,
-0.43243205547332764,
-0.2656581699848175,
0.44928184151649475,
-0.5653306841850281,
0.8668001294136047,
-0.08890816569328308,
0.2922721207141876,
0.09233661741018295,
-0.4882355034351349,
-0.1513461172580719,
-0.31698334217071533,
-0.11201739311218262,
0.1786644160747528,
0.2904830574989319,
-0.5293527245521545,
-0.20172838866710663,
-0.2791549265384674,
0.22460904717445374,
0.36803147196769714,
-0.5529807806015015,
0.12535813450813293,
-0.29279962182044983,
-0.45027539134025574,
0.3587653338909149,
0.1969805657863617,
0.22344009578227997,
0.4121765196323395,
-0.2714478671550751,
0.33322757482528687,
-0.04903537407517433,
-0.08317311853170395,
0.6422032117843628,
0.1369241625070572,
0.14081086218357086,
0.23702237010002136,
-0.552887499332428,
0.26336735486984253,
0.7056581974029541,
0.32069188356399536,
-0.6593910455703735,
-0.05663808807730675,
-0.04344215989112854,
-0.08528368175029755,
-0.252948522567749,
0.26485663652420044,
-0.06172232702374458,
-0.7160239815711975,
-0.8947309255599976,
-0.20321930944919586,
-0.3990945518016815,
-0.3558046519756317,
-0.2732199430465698,
-0.4548020660877228,
-0.23730172216892242,
-0.02796645276248455,
-0.026857078075408936,
-1.2312426567077637,
-0.166404590010643,
0.010131913237273693,
-0.46847885847091675,
0.8888545036315918,
-0.10704375058412552,
0.511876106262207,
0.1835084855556488,
-0.06046435981988907,
-0.07538808882236481,
-0.14877933263778687,
-0.6461517214775085,
0.714151918888092,
0.4206151068210602,
0.6329997181892395,
0.028599083423614502,
0.5264793634414673,
-0.039509594440460205,
0.20934320986270905,
-0.5014294385910034,
0.6459185481071472,
0.03768833726644516,
-0.4485294222831726,
-0.9576144218444824,
-0.2087726593017578,
-0.13214239478111267,
0.33895304799079895,
-0.057071488350629807,
0.14889313280582428,
-0.471024751663208,
-0.28199902176856995,
-0.2396964132785797,
-0.6706560850143433,
-0.034591998904943466,
-0.403148353099823,
-0.3296332061290741,
-0.204678475856781,
0.029805773869156837,
0.42184045910835266,
0.26462769508361816,
0.18040376901626587,
0.1766502559185028,
0.3151637017726898,
0.42077574133872986,
0.5507192015647888,
-0.4153490662574768,
-0.04266728088259697,
0.42442622780799866,
0.14776800572872162,
0.4413391351699829,
0.5309045314788818,
-0.02060781605541706,
-0.1780318319797516,
-0.5258298516273499,
-0.6962215304374695,
0.31094181537628174,
-0.6249155402183533,
-0.03183133527636528,
-0.057786975055933,
0.29530417919158936,
-0.3138289153575897,
0.3888426721096039,
0.32361215353012085,
-0.3556857705116272,
-0.12882351875305176,
-0.22864161431789398,
-0.2022656947374344,
-0.1085004061460495,
-0.2920563817024231,
0.0232547577470541,
0.14292778074741364,
0.09992588311433792,
0.37325334548950195,
-0.6146408319473267,
-0.08177176862955093,
0.6492974758148193,
-0.24977785348892212,
1.2851054668426514,
-0.4217453896999359,
-0.31376466155052185,
1.6247203350067139,
0.5579333305358887,
-0.12185569852590561,
-0.250296950340271,
0.008053270168602467,
0.5224176645278931,
-0.4653889834880829,
-1.0275012254714966,
0.2741750180721283,
-0.023234717547893524,
-0.15245158970355988,
-0.10504905134439468,
-0.34970587491989136,
0.2885434627532959,
-0.011359268799424171,
-0.10843964666128159,
-0.476919561624527,
0.3684278726577759,
0.346268892288208,
-0.17038901150226593,
-0.31541818380355835,
0.16716250777244568,
-0.017106058076024055,
0.4783917963504791,
-0.8479784727096558,
0.3448886275291443,
0.8905630111694336,
-0.2834213376045227,
0.5406157374382019,
0.8079450726509094,
0.4578422009944916,
1.0538573265075684,
-0.2745433449745178,
0.36643579602241516,
-0.3395443558692932,
0.5930736064910889,
-0.43718892335891724,
-0.26093336939811707,
0.03015001490712166,
-0.008007999509572983,
0.10705570876598358,
0.20615525543689728,
0.3055811822414398,
0.3863009214401245,
1.0327274799346924,
-0.5875902771949768,
-0.4598175883293152,
-0.03956008329987526,
-0.5330608487129211,
-0.25363948941230774,
-0.36203619837760925,
-0.5028253793716431,
0.2774622440338135,
0.30055737495422363,
0.5602757930755615,
0.49592068791389465,
-0.2095823734998703,
0.39278867840766907,
0.28427812457084656,
-0.09877442568540573,
-0.3651942014694214,
0.7109835743904114,
-0.003620182629674673,
-0.19011971354484558,
0.10992716252803802,
-0.26988935470581055,
0.344766765832901,
0.16112923622131348,
-0.5069760680198669,
-0.1894749253988266,
-0.6286895871162415,
0.6138186454772949,
0.5195587873458862,
0.6736363768577576,
0.04132666811347008,
-0.5713046193122864,
0.09548907727003098,
0.5212153792381287,
-0.7530618906021118,
0.7851144075393677,
0.6183698773384094,
-0.38290345668792725,
-0.15365691483020782,
-0.3219003677368164,
-0.24901944398880005,
0.7288656234741211,
-0.2193513810634613,
0.056442394852638245,
-0.4444354474544525,
-0.02929612621665001,
0.14990895986557007,
-0.9566910862922668,
-0.14925989508628845,
-0.5276743769645691,
0.49657493829727173,
0.2950044274330139,
0.3993581533432007,
0.13572309911251068,
0.49995726346969604,
0.10353738814592361,
-0.13116754591464996,
0.7045522332191467,
-0.24199336767196655,
-0.02235090546309948,
0.18017402291297913,
-0.15636081993579865,
0.1164812296628952,
-0.47459444403648376,
0.13062304258346558,
-0.031303521245718,
0.07700180262327194,
-5.729463577270508,
-0.17483873665332794,
-0.38332849740982056,
-0.33055180311203003,
-0.04810512438416481,
0.09640449285507202,
0.9499003291130066,
0.004159176256507635,
0.5965356230735779,
-0.3799455761909485,
0.7928048372268677,
0.21304599940776825,
0.4059610366821289,
-0.4876841902732849,
-0.3000129163265228,
0.17458020150661469,
-0.18152272701263428,
0.006164410151541233,
0.38767850399017334,
-0.03630182147026062,
0.3217935860157013,
-0.09974832087755203,
-0.4087395668029785,
0.023207232356071472,
-0.12893587350845337,
0.22006075084209442,
-0.5187006592750549,
0.25306764245033264,
-0.44652223587036133,
-0.04689896106719971,
0.40430015325546265,
-1.1216998100280762,
-0.027729008346796036,
-0.19770635664463043,
-0.5571435689926147,
-0.361650288105011,
0.35254383087158203,
-0.16128937900066376,
-0.05467282235622406,
0.1856747567653656,
0.09381068497896194,
-0.23126287758350372,
0.06528540700674057,
-0.34818071126937866,
-0.04642336070537567,
-0.08967765420675278,
-0.2686184048652649,
0.3092007339000702,
-0.046465251594781876,
1.0390021800994873,
0.008133583702147007,
-0.19297964870929718,
0.367244154214859,
0.969559907913208,
0.26813653111457825,
0.3339734971523285,
-0.12627851963043213,
0.5410851240158081,
-0.42715978622436523,
0.18915626406669617,
-0.12567606568336487,
-0.3322588801383972,
-0.10078246891498566,
-0.5466988682746887,
0.32651975750923157,
0.2602883577346802,
-0.5777962803840637,
-0.030028650537133217,
0.40346598625183105,
-0.3120356798171997,
-0.42360639572143555,
-0.10825757682323456,
0.2757127285003662,
-0.8481585383415222,
0.3221100866794586,
-0.953127920627594,
0.07682816684246063,
-0.32608652114868164,
-0.20981018245220184,
-0.22889554500579834,
-0.09633836150169373,
-0.257233589887619,
-0.12430212646722794,
-0.45120492577552795,
0.19960454106330872,
-0.14658057689666748,
0.10339972376823425,
-0.344078928232193,
0.14704245328903198,
0.2537687122821808,
0.477944940328598,
-0.5206660628318787,
0.24048486351966858,
0.15950745344161987,
0.4194069802761078,
0.5164350271224976,
0.24943727254867554,
0.34075888991355896,
0.5960575342178345,
-0.1330672651529312,
0.941564679145813,
-0.8054046630859375,
-0.2545749545097351,
-1.3138936758041382,
-0.30707815289497375,
0.12414275109767914,
-0.29449155926704407,
0.04423917457461357,
0.6130532622337341,
-0.20688554644584656,
0.38885805010795593,
-0.017004793509840965,
-0.3040033280849457,
-0.040972914546728134,
0.5697106719017029,
-0.1833070069551468,
0.2503252923488617,
0.37108173966407776,
0.5701949596405029,
0.18471579253673553,
0.387442022562027,
0.476202130317688,
-0.32894542813301086,
0.015791600570082664,
0.40617823600769043,
-0.01585199311375618,
0.40575599670410156,
-0.0927206352353096,
-0.435259073972702,
-0.4194788932800293,
0.016795005649328232,
0.1576164811849594,
-0.23810014128684998,
-0.11301076412200928,
0.31207627058029175,
0.24097247421741486,
-0.3794308006763458,
-0.012616446241736412,
0.3282201290130615,
-0.09837432950735092,
-0.16338330507278442,
-0.005106855183839798,
-0.2559261918067932,
0.4048432409763336,
-0.18391823768615723,
0.10346142202615738,
-0.21534253656864166,
0.16351716220378876,
-0.17611275613307953,
-0.44551777839660645,
0.1964663863182068,
0.4024154245853424,
0.12776179611682892,
0.21284939348697662,
-1.0648729801177979,
0.39785873889923096,
0.3934500217437744,
0.22040122747421265,
0.19190151989459991,
-0.30208975076675415,
0.0859769806265831,
-0.3769376277923584,
-0.7596607208251953,
0.2387397289276123,
-0.257149338722229,
0.15170465409755707,
0.4743322730064392,
-0.8807203769683838,
0.05785160884261131,
0.18679068982601166,
-0.4281288683414459,
0.10928782820701599,
-0.06068109720945358,
-0.05950396880507469,
0.1663070023059845,
0.4142323434352875,
-0.3154134154319763,
-0.049795880913734436,
0.08835708349943161,
0.7238209843635559,
-0.429821252822876,
-0.17649640142917633,
-0.20222453773021698,
0.8460860252380371,
0.437370240688324,
0.27316901087760925,
-0.30305778980255127,
-0.2577955424785614,
-0.28950053453445435,
-0.08574292063713074,
0.3040655553340912,
0.38936999440193176,
0.34859442710876465,
0.008969813585281372,
0.33409127593040466,
0.1351311206817627,
-0.14459747076034546,
0.4269844591617584,
-0.09601682424545288,
-0.5637566447257996,
-0.46191367506980896,
0.628580629825592,
-0.36730021238327026,
0.4187663793563843,
0.03192863613367081,
-0.18616925179958344,
-0.2925165891647339,
-0.7716261148452759,
0.14843782782554626,
-0.35038506984710693,
-0.2801700830459595,
-0.2979274094104767,
-0.10907196253538132,
0.7502925395965576,
-0.16959069669246674,
0.06893771141767502,
-0.20343400537967682,
-0.4384559690952301,
0.1841789186000824,
0.3869110941886902,
-0.2072475701570511,
-0.027244487777352333,
0.27915018796920776,
-0.12880674004554749,
-0.1141696646809578,
0.8585198521614075,
0.21000750362873077,
-1.2632815837860107,
-0.26160451769828796,
0.32630741596221924,
0.08577391505241394,
-0.41223785281181335,
0.40675100684165955,
0.18586985766887665,
-0.9812183976173401,
-0.14888916909694672,
0.1393173336982727,
-0.23854002356529236,
-0.005734656937420368,
0.5605267286300659,
0.511461079120636,
0.31066954135894775,
-0.21672089397907257,
-0.5320191383361816,
0.10668681561946869,
0.0643216073513031,
0.524379551410675,
-0.38142526149749756,
-0.3499620258808136,
0.4659457802772522,
0.11972245573997498,
-0.40460005402565,
-0.14156675338745117,
0.24698272347450256,
0.7504153251647949,
-0.3997786343097687,
-0.0698389783501625,
-0.5112533569335938,
0.11619862914085388,
-0.32448071241378784,
0.1353691816329956,
-0.15007321536540985,
0.014329928904771805,
-0.028479158878326416,
-0.2629289925098419,
-0.4676855504512787,
-0.03082999773323536,
-0.44508376717567444,
0.22467787563800812,
0.2136784791946411,
-0.03228146210312843,
-0.33790352940559387,
0.4322476387023926,
0.796448826789856,
-0.6734285950660706,
0.6602901816368103,
-0.583059549331665,
0.018530860543251038,
-0.19535492360591888,
0.4305756092071533,
-0.45109298825263977,
-0.3943832814693451,
0.073884516954422,
0.010924916714429855,
0.14782461524009705,
-0.27677562832832336,
-0.013699366711080074,
-0.03209269791841507,
-0.048403892666101456,
-0.24320420622825623,
-0.4294867217540741,
-0.06522263586521149,
-0.7573355436325073,
-0.29404404759407043,
-0.17348353564739227,
-0.05202290788292885,
-0.05325955152511597,
0.3174443244934082,
-0.5576063990592957,
-0.2499275654554367,
-0.722674548625946,
0.8531326055526733,
0.3789450526237488,
-0.40199074149131775,
0.2484169900417328,
-0.3012808561325073,
0.033918485045433044,
0.438564658164978,
0.014539075084030628,
-0.1642252504825592,
0.25061336159706116,
-0.0963367447257042,
0.45311617851257324,
-0.38248831033706665,
-0.17476044595241547,
0.35739442706108093,
-0.3267718553543091,
-0.37373870611190796,
0.28448668122291565,
0.09766212105751038,
0.6022404432296753,
1.055808186531067,
0.22187793254852295,
-0.20591028034687042,
-0.036604881286621094,
1.0436898469924927,
-0.2375735491514206,
-0.3449046313762665,
-0.13054253160953522,
0.45834797620773315,
0.5308749079704285,
-0.42550328373908997,
-0.5885810852050781,
0.34317195415496826,
0.12740063667297363,
0.4229497015476227,
0.2556762099266052,
-0.20577487349510193,
-0.06486939638853073,
0.0964243933558464,
0.38773858547210693,
0.404178261756897,
-0.03644693270325661,
0.06216895207762718,
0.03768434748053551,
0.026936007663607597,
-0.052712783217430115,
0.31966379284858704,
0.4127567708492279,
0.24495311081409454,
0.2898372709751129,
-0.5165348052978516,
0.03864547237753868,
0.057359810918569565,
-0.3609110414981842,
0.20615935325622559,
-0.020642438903450966,
-0.16481484472751617,
-0.5039047002792358,
0.09066234529018402,
0.3137105107307434,
-0.007551149465143681,
-0.10041218996047974,
0.46526652574539185,
0.08413602411746979,
-0.2612128257751465,
-0.06625615060329437,
-0.1772398054599762,
-0.3348124623298645,
-0.07433010637760162,
0.109070785343647,
-0.044643353670835495,
-0.1008407399058342,
0.45653167366981506,
0.18809354305267334,
-0.06207100301980972,
-0.012820394709706306,
0.4337473213672638,
-0.367629736661911,
0.6815013289451599,
-0.3904651403427124,
-0.5755494236946106,
-0.0872519239783287,
-0.4430767297744751,
-0.24823777377605438,
-0.4139496386051178,
-0.11275159567594528,
-0.019842468202114105,
-0.18717500567436218,
-0.41366150975227356,
0.14101560413837433,
-0.9933278560638428,
-0.2086677849292755,
0.21570844948291779,
0.1368241012096405,
-0.0514429435133934,
0.1844598650932312,
0.33383625745773315,
0.2373475432395935,
0.5398852825164795,
0.056346677243709564,
-0.04806841164827347,
0.044021282345056534,
0.3967258036136627,
-0.6302019953727722,
0.12124471366405487,
0.05331879481673241,
0.03216160088777542,
-0.9085603952407837,
-0.2574034035205841,
1.0068764686584473,
0.4402151107788086,
-0.2157042920589447,
0.31762030720710754,
-0.11490604281425476,
0.47991031408309937,
0.541216254234314,
-0.8226091861724854,
0.06036948785185814,
-0.5989582538604736,
-0.19302453100681305,
-0.7991822361946106,
0.32126128673553467,
0.44674915075302124,
0.07447971403598785,
0.07032570987939835,
0.5474885702133179,
0.39786291122436523,
-0.6796614527702332,
0.5748358368873596,
-0.1827012151479721,
-0.2504061162471771,
-0.4813232719898224,
0.6306734085083008,
-0.6408126950263977,
0.22254741191864014,
0.13553892076015472,
0.6088237166404724,
-0.05714277923107147,
0.103052519261837,
0.4274024963378906,
-0.7244990468025208,
-0.05495308339595795,
-0.2364664077758789,
-0.3960040807723999,
0.612296998500824,
-0.09974557906389236,
-0.03618142008781433,
-0.86521315574646,
0.513272225856781,
0.022090645506978035,
-0.24183709919452667,
-0.0518895760178566,
-0.18869102001190186,
-0.08432479202747345,
0.27591726183891296,
0.00940829049795866,
0.06900150328874588,
-0.23840630054473877,
-0.0031898661982268095
] |
Influenza A (H5N1) viruses are strong candidates for causing the next influenza pandemic if they acquire the ability for efficient human-to-human transmission. A major public health goal is to make efficacious vaccines against these viruses by using novel approaches, including cell-culture system, reverse genetics, and adjuvant development. Important consideration for the strategy includes preparation of vaccines from a currently circulating strain to induce broad-spectrum immunity toward newly emerged human H5 strains. This strategy would be a good solution early in a pandemic until an antigenically matched and approved vaccine is produced. The concept of therapeutic vaccines (e.g., antidisease vaccine) directed at diminishing the cytokine storm frequently seen in subtype H5N1–infected persons is underscored. Better understanding of host–virus interaction is essential to identify tools to produce effective vaccines against influenza (H5N1). | [
-0.01133066974580288,
0.02416887879371643,
-0.010034172795712948,
0.009918197989463806,
0.025556273758411407,
-0.01170438528060913,
0.008654871955513954,
0.019039571285247803,
-0.014935070648789406,
-0.06470291316509247,
-0.0014646465424448252,
0.018163083121180534,
-0.011531834490597248,
0.010229350998997688,
0.005981318652629852,
0.008060448803007603,
-0.0030803997069597244,
0.00047440966591238976,
0.005909987725317478,
-0.01930055394768715,
0.008905477821826935,
0.006237664259970188,
0.012515995651483536,
-0.0037804096937179565,
-0.011222517117857933,
-0.0067352354526519775,
-0.018546998500823975,
-0.009365610778331757,
-0.010258721187710762,
-0.012881938368082047,
0.032761529088020325,
0.006970454007387161,
0.032499492168426514,
0.0019517671316862106,
-0.0013553211465477943,
0.010153569281101227,
-0.006536567583680153,
0.028346169739961624,
0.02703823894262314,
-0.003038653638213873,
0.00681679230183363,
-0.01376772578805685,
0.002821453148499131,
-0.013003847561776638,
-0.009056071750819683,
0.05169183015823364,
-0.002936264267191291,
0.01957719773054123,
0.022053346037864685,
0.010737848468124866,
-0.00034276762744411826,
-0.01157737523317337,
-0.019282516092061996,
-0.013329755514860153,
-0.007482156157493591,
0.014666172675788403,
0.022489335387945175,
0.011352633126080036,
-0.03424292057752609,
0.007175548933446407,
0.001513118389993906,
-0.01315802801400423,
-0.0007307645864784718,
-0.00957723893225193,
-0.004792007617652416,
-0.06669357419013977,
0.003521982580423355,
0.017054200172424316,
0.008335625752806664,
0.012484066188335419,
0.01414678804576397,
0.009387079626321793,
-0.002481377450749278,
0.014179451391100883,
-0.05930096656084061,
-0.01760832592844963,
-0.00625967513769865,
0.028027592226862907,
0.011358781717717648,
0.011940766125917435,
-0.017931856215000153,
-0.010539019480347633,
0.031011249870061874,
0.00639164075255394,
-0.01624229922890663,
0.0057027870789170265,
-0.0058100479654967785,
-0.000007217051461338997,
-0.005065882578492165,
-0.009756366722285748,
0.008810561150312424,
-0.004057100508362055,
-0.07047969102859497,
-0.019364988431334496,
0.0035831891000270844,
-0.012443026527762413,
0.004977366887032986,
0.005042736418545246,
-0.015324229374527931,
-0.018609408289194107,
0.0033228187821805477,
0.008507962338626385,
0.009570563212037086,
-0.0025150226429104805,
-0.005861167795956135,
0.007880503311753273,
-0.013644964434206486,
-0.0026211729273200035,
0.0036568238865584135,
0.0033060971181839705,
0.004035492427647114,
-0.030724648386240005,
0.017619973048567772,
0.030594410374760628,
-0.016189033165574074,
0.025372765958309174,
-0.010701224207878113,
0.04104672372341156,
0.018596835434436798,
0.006198987830430269,
-0.008615955710411072,
-0.0018468759953975677,
0.006729890592396259,
-0.012631425634026527,
0.0005008656880818307,
-0.0021392996422946453,
-0.0004168744198977947,
-0.014789164066314697,
0.015980733558535576,
0.005345502402633429,
-0.012256225571036339,
-0.001384402858093381,
-0.014574247412383556,
-0.008180040866136551,
-0.004527069162577391,
0.005148895084857941,
-0.02131005749106407,
-0.006794837769120932,
-0.0020387026015669107,
-0.005805312190204859,
-0.03207948058843613,
0.011759599670767784,
-0.000023059546947479248,
0.022447925060987473,
0.0051544662564992905,
0.005592032801359892,
-0.015988655388355255,
0.009997558780014515,
0.02863646298646927,
-0.0019198594382032752,
0.025188855826854706,
0.0016609113663434982,
-0.026878714561462402,
-0.017184749245643616,
0.003999313339591026,
0.012444397434592247,
-0.009496969170868397,
-0.030560269951820374,
-0.04424945265054703,
0.01687607727944851,
0.04141015186905861,
-0.033361632376909256,
-0.009429862722754478,
0.008558783680200577,
0.03288321942090988,
0.009277941659092903,
0.01584549993276596,
-0.013715986162424088,
-0.012876800261437893,
0.013622532598674297,
-0.022577054798603058,
0.012984119355678558,
-0.011794930323958397,
0.011381198652088642,
0.024227876216173172,
-0.006673442665487528,
0.0044481572695076466,
0.00898054987192154,
0.00008269632235169411,
0.06591401994228363,
-0.023038137704133987,
0.01708172634243965,
-0.020738258957862854,
0.0343397781252861,
0.012144056148827076,
-0.030825287103652954,
0.05051968991756439,
-0.00854388065636158,
-0.0030973157845437527,
0.004129575565457344,
0.011550987139344215,
-0.011354725807905197,
-0.01601063832640648,
-0.0040329257026314735,
-0.030795510858297348,
0.0047968048602342606,
0.009874110110104084,
0.0138311218470335,
-0.005512742325663567,
-0.01334107294678688,
0.03625388443470001,
0.007891549728810787,
0.05852685868740082,
0.0071436380967497826,
-0.016810446977615356,
0.003959194757044315,
-0.003023624885827303,
0.0056913625448942184,
-0.011014029383659363,
-0.036906689405441284,
0.03197620064020157,
-0.020709559321403503,
0.005649610422551632,
-0.008897554129362106,
0.002500839065760374,
-0.01306917890906334,
0.008660920895636082,
-0.007453213445842266,
-0.0004305093316361308,
-0.009009025990962982,
-0.0011229022638872266,
0.028983894735574722,
-0.02871052548289299,
-0.004712068475782871,
-0.0027945460751652718,
0.001343817450106144,
0.01098663080483675,
0.015748124569654465,
-0.0046668583527207375,
0.010619754903018475,
-0.006636199075728655,
-0.02456044778227806,
-0.011572670191526413,
-0.01689467579126358,
0.005566404201090336,
-0.0001726113259792328,
0.009980076923966408,
-0.04635895788669586,
0.01499413512647152,
-0.0154926348477602,
-0.007319146301597357,
0.010899577289819717,
0.03112770989537239,
0.004180473741143942,
-0.006238532718271017,
0.004086748696863651,
0.026262523606419563,
0.011242966167628765,
-0.018864359706640244,
-0.013040135614573956,
0.011481771245598793,
0.0007665641605854034,
0.00549915200099349,
-0.016662102192640305,
0.027188336476683617,
-0.004111455753445625,
0.023305542767047882,
0.029015790671110153,
0.027113500982522964,
0.019300954416394234,
0.004823882598429918,
0.010158812627196312,
-0.03019430860877037,
-0.0037441030144691467,
-0.005111874081194401,
0.05140987038612366,
0.0032171662896871567,
0.0007173987105488777,
0.007891256362199783,
-0.010487326420843601,
0.00613777618855238,
-0.005337120499461889,
-0.00728886341676116,
-0.08137452602386475,
-0.017029084265232086,
0.00956637691706419,
-0.03964577987790108,
0.013663221150636673,
0.01231144368648529,
0.00016040587797760963,
0.0058516557328403,
-0.026332352310419083,
0.014439557678997517,
0.010274797677993774,
0.015836672857403755,
0.0007371712708845735,
-0.02267533168196678,
-0.005799614358693361,
-0.010888790711760521,
0.0013733537634834647,
0.019827507436275482,
-0.04422054439783096,
-0.019953276962041855,
0.001953352242708206,
0.006213569547981024,
0.017654994502663612,
-0.027799762785434723,
-0.008174602873623371,
-0.005094336811453104,
0.0038371344562619925,
0.010784856975078583,
0.017954066395759583,
0.014585724100470543,
0.02214495837688446,
-0.04139822721481323,
0.024734534323215485,
-0.024995461106300354,
0.024150097742676735,
0.019027572125196457,
0.018333222717046738,
-0.02167584002017975,
-0.001925162156112492,
0.012197095900774002,
-0.00602873507887125,
0.016121432185173035,
-0.010075554251670837,
0.004772514570504427,
0.02125685103237629,
0.011202975176274776,
-0.014056301675736904,
0.007234666496515274,
0.02170364186167717,
0.005867761559784412,
-0.013925619423389435,
-0.002290877513587475,
0.021960416808724403,
0.016339490190148354,
-0.010044851340353489,
-0.010061001405119896,
-0.005701897665858269,
0.015307592228055,
-0.02176487073302269,
-0.00611634086817503,
-0.014587543904781342,
0.029497839510440826,
0.013746120035648346,
0.005846003070473671,
-0.03621084988117218,
-0.01032968144863844,
0.023214269429445267,
-0.003591896966099739,
-0.013173721730709076,
0.01718045212328434,
-0.006884866394102573,
0.007802493404597044,
0.028489992022514343,
-0.003984815441071987,
0.043630607426166534,
-0.004626747220754623,
-0.018009250983595848,
-0.031012332066893578,
-0.015880268067121506,
0.00458801444619894,
-0.023116998374462128,
0.012554396875202656,
-0.006582155823707581,
0.0034376434050500393,
-0.021718008443713188,
-0.008510525338351727,
0.009936682879924774,
-0.013877391815185547,
0.0014343082439154387,
-0.01922421343624592,
-0.022573601454496384,
-0.00006262259557843208,
-0.049521319568157196,
0.004372617695480585,
-0.026511918753385544,
-0.027972839772701263,
-0.007483003195375204,
-0.006363335065543652,
0.015481814742088318,
0.010089229792356491,
-0.017563318833708763,
-0.015389958396553993,
0.015868335962295532,
-0.009565502405166626,
-0.027186820283532143,
0.026865899562835693,
0.004578170832246542,
-0.04429367929697037,
-0.029696425423026085,
-0.022722745314240456,
0.014102793298661709,
0.014117815531790257,
-0.0034765731543302536,
-0.001293229404836893,
0.013116895221173763,
0.012857924215495586,
-0.0007419483736157417,
0.0005032396875321865,
0.07137273252010345,
-0.01598060503602028,
0.006383631844073534,
-0.020777083933353424,
0.00817682035267353,
-0.01343974657356739,
0.0019394652917981148,
-0.012429982423782349,
-0.01192769780755043,
-0.014322897419333458,
0.014797546900808811,
-0.053777895867824554,
-0.007330247201025486,
-0.018434248864650726,
-0.011181287467479706,
-0.035775598138570786,
0.00597298052161932,
-0.01944350078701973,
0.00283302110619843,
0.00941785704344511,
0.0024930154904723167,
-0.0032416495960205793,
-0.019589737057685852,
0.001408503856509924,
0.012837188318371773,
-0.0021613813005387783,
0.01343468576669693,
-0.009373541921377182,
0.004706493578851223,
0.009915407747030258,
0.017172880470752716,
0.023198891431093216,
0.0003502521722111851,
-0.005707279313355684,
0.010165305808186531,
-0.005354420747607946,
0.015625346451997757,
0.028960205614566803,
0.009739424102008343,
-0.011828141286969185,
-0.02529299445450306,
-0.02153557911515236,
0.005837556906044483,
0.018222255632281303,
-0.021179430186748505,
0.006767354905605316,
-0.017408639192581177,
-0.012707047164440155,
-0.006196154747158289,
0.008286216296255589,
-0.014126770198345184,
0.0030686056707054377,
0.004618032835423946,
0.03552137315273285,
-0.017543425783514977,
0.010901756584644318,
0.030421584844589233,
-0.023702841252088547,
0.01676618494093418,
-0.008664954453706741,
0.006782513111829758,
-0.01825449801981449,
0.027940453961491585,
-0.026983531191945076,
0.015800992026925087,
-0.01413570437580347,
-0.020328085869550705,
-0.0023700003512203693,
-0.004450024571269751,
-0.005020887590944767,
0.004095621407032013,
-0.007373013999313116,
0.014391048811376095,
0.011802420020103455,
-0.04197382181882858,
0.025256521999835968,
-0.03629736602306366,
0.014693615958094597,
-0.002809266559779644,
0.020848847925662994,
-0.009516298770904541,
-0.009423474781215191,
0.01588313654065132,
0.004228602163493633,
-0.002260351786389947,
-0.0024024304002523422,
-0.031054610386490822,
-0.07408727705478668,
-0.023388821631669998,
-0.0026200581341981888,
-0.010689932852983475,
0.0014002141542732716,
0.00641227001324296,
-0.01234738714993,
-0.007952194660902023,
-0.01616041734814644,
-0.01190221682190895,
-0.02349575236439705,
-0.012891249731183052,
0.043237779289484024,
0.017820600420236588,
0.014090998098254204,
0.019064350053668022,
-0.035090044140815735,
0.007602179888635874,
-0.020268868654966354,
0.0021264529787003994,
0.003966810181736946,
0.002544302958995104,
-0.025149427354335785,
-0.003220845479518175,
0.00983354076743126,
-0.08022862672805786,
-0.030679095536470413,
0.016398366540670395,
-0.02604714035987854,
0.010502511635422707,
-0.018705196678638458,
0.012547221034765244,
-0.0261878352612257,
0.0149453803896904,
-0.01593337394297123,
-0.003655553562566638,
-0.013688766397535801,
-0.011347861029207706,
-0.00046160537749528885,
0.02469070628285408,
-0.015890266746282578,
0.0012581371702253819,
0.0025706281885504723,
0.03141641989350319,
-0.009946735575795174,
0.019069954752922058,
0.023968400433659554,
-0.01766335964202881,
-0.009168660268187523,
-0.020653311163187027,
-0.019375085830688477,
-0.0016815871931612492,
0.014593390747904778,
0.0008689544629305601,
-0.010574184358119965,
0.002586836228147149,
0.0018876716494560242,
-0.0029980442486703396,
0.00732422573491931,
0.01982264593243599,
-0.006077887490391731,
0.0314752422273159,
-0.022234661504626274,
0.020068876445293427,
0.0021237782202661037,
-0.0025547705590724945,
0.02891566790640354,
-0.00045052915811538696,
0.009849396534264088,
-0.004907764028757811,
-0.013885416090488434,
0.010124105960130692,
0.0023012321908026934,
0.03611690551042557,
0.013072371482849121,
0.005890291649848223,
-0.016358904540538788,
0.0031523718498647213,
-0.017107727006077766,
0.005648544058203697,
0.0010279035195708275,
-0.005218932870775461,
-0.001495939097367227,
-0.0011872095055878162,
0.009998606517910957,
-0.0008745410013943911,
0.010444758459925652,
-0.003536190604791045,
0.07044586539268494,
-0.014100337401032448,
0.027112135663628578,
-0.0003954806597903371,
-0.01975438743829727,
0.0011794730089604855,
0.00347745418548584,
-0.011436502449214458,
-0.04711507633328438,
-0.024848349392414093,
0.04028350114822388,
-0.002713044174015522,
-0.011633671820163727,
0.014701051637530327,
-0.0036622779443860054,
0.01617111638188362,
0.015351798385381699,
-0.01775706186890602,
-0.026793943718075752,
-0.011296922340989113,
-0.011013906449079514,
-0.010579893365502357,
-0.029231633991003036,
-0.02451580949127674,
0.031654875725507736,
-0.005591311492025852,
-0.04234125465154648,
-0.010735055431723595,
-0.03559790551662445,
-0.005596693605184555,
-0.015563043765723705,
0.003962597344070673,
-0.00249375868588686,
-0.006790981628000736,
0.015479231253266335,
-0.01771056465804577,
0.007206340320408344,
-0.0007524595712311566,
0.013696298003196716,
0.03847222030162811,
-0.014506762847304344,
-0.012721738778054714,
-0.007765303831547499,
-0.019209928810596466,
0.013056688010692596,
-0.03709813207387924,
0.0062892502173781395,
0.019669583067297935,
0.018699051812291145,
0.0178053118288517,
0.012083809822797775,
-0.005685549229383469,
0.018277883529663086,
-0.0024723191745579243,
0.013056998141109943,
-0.00866695586591959,
-0.01577850803732872,
0.022435829043388367,
-0.018451819196343422,
0.0047617824748158455,
-0.01545900758355856,
-0.017167111858725548,
0.004587092902511358,
-0.008746214210987091,
0.0002877223305404186,
-0.015250058844685555,
0.02217177115380764,
-0.015201550908386707,
-0.01267529372125864,
0.014568304643034935,
0.0026040393859148026,
0.032437216490507126,
0.008329108357429504,
-0.01531247515231371,
0.021168407052755356,
0.005416629835963249,
0.04553242772817612,
-0.002935296855866909,
0.019868753850460052,
-0.004852245096117258,
-0.00016724492888897657,
-0.013833201490342617,
0.023702967911958694,
0.021663932129740715,
0.010823570191860199,
-0.0006437725387513638,
0.004712398629635572,
0.021638963371515274,
-0.0072212317027151585,
0.010906987823545933,
0.018907973542809486,
0.012290459126234055,
0.0013760847505182028,
-0.011980583891272545,
0.0043758824467659,
0.035995956510305405,
0.013482669368386269,
0.008684806525707245,
0.028624434024095535,
0.014177542179822922,
-0.002061686711385846,
0.000024302396923303604,
-0.012985773384571075,
-0.014782357960939407,
0.027106095105409622,
-0.01010743249207735,
0.038078367710113525,
-0.004853871650993824,
-0.005134650506079197,
0.01559312455356121,
0.012450143694877625,
0.033746663480997086,
0.005083892028778791,
-0.0007936791516840458,
0.015255294740200043,
0.019904540851712227,
-0.014253836125135422,
0.034008387476205826,
-0.010372495278716087,
-0.006938718259334564,
-0.024408943951129913,
0.020971162244677544,
-0.00016172253526747227,
0.03241248056292534,
0.0005569895729422569,
-0.0136216776445508,
-0.0076269907876849174,
-0.018607795238494873,
-0.02448081411421299,
0.012887660413980484,
0.012540698982775211,
-0.03770572692155838,
0.009915385395288467,
0.02153986319899559,
0.005618210416287184,
0.01650281995534897,
0.0011836537159979343,
-0.00559151079505682,
-0.018755968660116196,
0.004348176531493664,
-0.02602589875459671,
0.0024650548584759235,
0.00841466337442398,
-0.0023798421025276184,
0.008976900950074196,
0.00022354465909302235,
0.012746766209602356,
0.02129402570426464,
0.02046125754714012,
-0.0063622258603572845,
0.009944413788616657,
0.016512900590896606,
-0.008301112800836563,
-0.00819975696504116,
0.005171080119907856,
0.020513512194156647,
0.007544008083641529,
-0.02400435321033001,
-0.0025179763324558735,
0.018761005252599716,
0.021338557824492455,
0.01867431215941906,
0.008490528911352158,
0.01563766784965992,
-0.006170266307890415,
0.001816758420318365,
0.03735003620386124,
-0.0014934963546693325,
0.0027579092420637608,
0.014588331803679466,
0.003328255843371153,
-0.01219425443559885,
-0.007033070083707571,
0.006979337427765131,
-0.01724128983914852,
-0.019484378397464752,
-0.025706637650728226,
0.0187730360776186,
-0.05516521632671356,
0.0040615759789943695,
0.011800544336438179,
-0.01852312684059143,
0.013594997115433216,
-0.0057076094672083855,
0.00031301984563469887,
0.001649805810302496,
-0.010516580194234848,
0.0303057674318552,
0.030390460044145584,
0.006787559017539024,
-0.013032116927206516,
-0.01307469792664051,
-0.011102879419922829,
0.00398715864866972,
-0.009204825386404991,
-0.0462021566927433,
-0.0070369653403759,
-0.041549116373062134,
0.01144133135676384,
0.02904863841831684,
0.0025976886972784996,
-0.015720650553703308
] | [
0.08222053945064545,
-0.05279982462525368,
-0.12334985285997391,
-0.17338240146636963,
-0.03181589022278786,
-0.3000258207321167,
0.4654318690299988,
0.09835337102413177,
-0.2424933761358261,
-0.8609541058540344,
0.19315819442272186,
-0.045448433607816696,
-0.6911274194717407,
0.41180720925331116,
0.03606618940830231,
0.2741166055202484,
0.29907676577568054,
0.40877780318260193,
-0.18282495439052582,
-0.2031318098306656,
-0.51780766248703,
-0.3203222155570984,
-0.2424761950969696,
0.09955759346485138,
0.1941385567188263,
-0.3616405427455902,
0.6064106225967407,
-0.021256547421216965,
0.45604678988456726,
-0.3884780704975128,
0.3874061405658722,
0.3970959186553955,
-0.05981697514653206,
-0.3606361746788025,
-0.48837336897850037,
-0.258789986371994,
-0.3279855251312256,
0.03178808465600014,
-0.26212769746780396,
-0.32844337821006775,
-0.3770151138305664,
-0.21912331879138947,
-0.4993719160556793,
0.6027317047119141,
0.06232505664229393,
-0.8010610938072205,
-1.127210259437561,
0.35924720764160156,
-0.08342008292675018,
0.06731836497783661,
0.46713340282440186,
-0.0872940868139267,
-0.2010076493024826,
0.43327420949935913,
-0.023121166974306107,
0.459406316280365,
-0.4280415177345276,
-0.17812250554561615,
0.13960765302181244,
-0.19599634408950806,
0.19243130087852478,
-0.5089887380599976,
-0.07167919725179672,
0.45875173807144165,
-0.025093136355280876,
0.6943753957748413,
0.5248112678527832,
0.061665840446949005,
-0.16182446479797363,
-0.4574313163757324,
-0.23379750549793243,
-0.6476075053215027,
-0.2610216438770294,
0.24237486720085144,
-0.005154239013791084,
-0.4350166320800781,
-0.09995871037244797,
-0.8071857690811157,
0.27051082253456116,
0.36671510338783264,
-0.03911386430263519,
0.33293625712394714,
-0.10512134432792664,
-0.5038815140724182,
0.48021039366722107,
0.20855940878391266,
0.23846933245658875,
0.7808504700660706,
-0.4727969169616699,
0.3013499677181244,
0.3597698509693146,
0.07520993798971176,
0.46124422550201416,
-0.10401377081871033,
0.4163520932197571,
0.4864828586578369,
-0.004406149499118328,
0.24454668164253235,
0.13695970177650452,
-0.06748661398887634,
-0.47616860270500183,
-0.2588806748390198,
-0.3105461001396179,
-0.4874520003795624,
-0.3185988962650299,
-0.49724075198173523,
-0.24655649065971375,
-0.6989074945449829,
-0.4029306173324585,
-0.060513656586408615,
-0.1633254438638687,
0.13217762112617493,
-0.03485400229692459,
-0.321661114692688,
-0.6166233420372009,
0.24989034235477448,
0.33452969789505005,
-0.354063481092453,
0.071426160633564,
-0.07887548208236694,
-0.00038674139068461955,
1.2581346035003662,
-0.23641853034496307,
0.4286765456199646,
-0.0936080813407898,
-0.15056435763835907,
0.460391640663147,
0.1761624664068222,
-0.23449306190013885,
0.26244527101516724,
-0.002986720995977521,
0.6407408714294434,
-0.4283994734287262,
-0.15705786645412445,
0.25936388969421387,
0.06304805725812912,
-0.5579965710639954,
0.5888018608093262,
0.3699398636817932,
-0.5644121170043945,
-0.46402207016944885,
-0.7138880491256714,
0.09189176559448242,
0.28460603952407837,
-0.06668966263532639,
0.25975242257118225,
-0.5256019830703735,
-0.061406273394823074,
-0.004701703786849976,
-0.2699008584022522,
0.12682297825813293,
-0.3356063663959503,
-0.6390930414199829,
0.5018598437309265,
-0.028004469349980354,
0.3952338397502899,
0.21013857424259186,
-0.08115413039922714,
0.059080496430397034,
0.45636680722236633,
0.6017485857009888,
0.14851261675357819,
-0.42162826657295227,
-0.2868134081363678,
0.3539784550666809,
-0.027667390182614326,
-0.08425910025835037,
0.4780917763710022,
-0.19433000683784485,
-0.6624658703804016,
-0.33621305227279663,
-0.09628719836473465,
-0.027565574273467064,
-0.8144717216491699,
0.24618719518184662,
-0.36685216426849365,
0.4410073459148407,
-0.09763085842132568,
0.3235337734222412,
0.39152902364730835,
-0.4762004315853119,
0.261653333902359,
0.1339457929134369,
-0.6385740637779236,
0.4537390172481537,
0.2571578025817871,
-0.1440296620130539,
0.03084023855626583,
0.1726013869047165,
0.15563589334487915,
-0.31577280163764954,
-0.05581820383667946,
0.04413227364420891,
-0.37085869908332825,
0.7986140251159668,
-0.036825891584157944,
-0.06497818976640701,
1.8430591821670532,
0.2826477587223053,
-0.17219115793704987,
0.15563248097896576,
0.10676249861717224,
0.48719874024391174,
-0.37042850255966187,
-0.9421166777610779,
-0.10132037103176117,
0.15042805671691895,
-0.17313186824321747,
-0.2992097735404968,
0.33604615926742554,
0.8607171177864075,
0.10966731607913971,
0.08559199422597885,
-0.748164176940918,
0.1651078462600708,
0.26929771900177,
-0.17435990273952484,
0.006405399646610022,
-0.3901096284389496,
0.05202566832304001,
0.6487835645675659,
-0.8303152322769165,
0.3292384147644043,
0.9395660758018494,
0.0817686915397644,
0.536623477935791,
0.42072421312332153,
-0.1454887092113495,
0.8287623524665833,
-0.5447418689727783,
0.21093332767486572,
-0.35942789912223816,
0.500469446182251,
-0.48282861709594727,
-0.08158591389656067,
0.22989286482334137,
-0.07399357110261917,
-0.056742310523986816,
0.01336477417498827,
0.14176122844219208,
0.4118558466434479,
0.5061911344528198,
-0.4907482862472534,
0.3632981777191162,
-0.022915659472346306,
-0.28986331820487976,
0.08106572180986404,
-0.08346067368984222,
-0.6273866891860962,
-0.17673058807849884,
0.31045830249786377,
0.6474819779396057,
0.6177681684494019,
-0.5877493023872375,
0.2218519151210785,
-0.1519029140472412,
-0.15800586342811584,
-0.08327680826187134,
0.18145421147346497,
-0.21325361728668213,
-0.30316832661628723,
0.2329951822757721,
0.18775741755962372,
0.44356101751327515,
0.05181395635008812,
-0.4787740111351013,
-0.5242663025856018,
-0.5326993465423584,
0.28707173466682434,
0.824277400970459,
0.952817976474762,
0.24019595980644226,
-0.4686366617679596,
-0.15669561922550201,
0.259016752243042,
-0.5355857014656067,
0.3747933506965637,
1.1027277708053589,
-0.7466011047363281,
0.013635685667395592,
-0.053051263093948364,
0.26204735040664673,
0.6894893050193787,
-0.7481808662414551,
-0.4340136647224426,
-0.44798311591148376,
-0.03249558061361313,
-0.43199843168258667,
-1.0341726541519165,
0.10607694834470749,
-0.1692158579826355,
0.36791831254959106,
-0.21863268315792084,
-0.20311369001865387,
0.1958366483449936,
-0.24476291239261627,
-0.07678016275167465,
0.6638913154602051,
0.4347240626811981,
-0.1167886033654213,
-0.22506754100322723,
0.32945385575294495,
-0.2413169890642166,
-0.2901900112628937,
-0.22640402615070343,
0.2963423430919647,
0.023510945960879326,
-0.045828770846128464,
-5.983882427215576,
-0.4195958971977234,
-0.030659133568406105,
0.2231431007385254,
-0.6927272081375122,
0.026452455669641495,
1.070898413658142,
-0.18601194024085999,
0.23988516628742218,
0.17732802033424377,
0.7588144540786743,
0.5228991508483887,
0.3498890995979309,
-0.34098371863365173,
-0.405636727809906,
-0.17512200772762299,
0.1873302012681961,
0.11830875277519226,
0.35236233472824097,
0.049406249076128006,
-0.06092486158013344,
0.339484840631485,
-0.11039960384368896,
0.4525199234485626,
0.02902091294527054,
-0.29443901777267456,
-0.847315788269043,
0.49554309248924255,
-0.038300059735774994,
0.45694807171821594,
0.2596041262149811,
-0.2564420700073242,
0.16861574351787567,
-0.2476430982351303,
-0.3799538016319275,
0.10444208234548569,
-0.12180528789758682,
-0.2964828908443451,
-0.32307136058807373,
-0.29102858901023865,
0.047070249915122986,
-0.22010040283203125,
-0.05909173935651779,
-0.14151215553283691,
-0.31696954369544983,
-0.1809927225112915,
0.33920127153396606,
0.36917686462402344,
0.08430256694555283,
0.681996762752533,
-0.007091643288731575,
-0.06738288700580597,
0.5283098220825195,
0.4224553406238556,
0.2992786467075348,
0.11177479475736618,
0.0955173447728157,
0.15562991797924042,
-0.35162124037742615,
-0.005467175971716642,
-0.1474599391222,
-0.10915189236402512,
-0.05540907755494118,
-0.228734090924263,
0.2725163698196411,
-0.04759771376848221,
-0.20426079630851746,
-0.9828977584838867,
0.4818338453769684,
0.11372347921133041,
-0.3480539917945862,
0.295887291431427,
0.45524266362190247,
-0.7258602380752563,
0.28053775429725647,
-0.5372822880744934,
-0.05219755321741104,
0.37364476919174194,
0.13247089087963104,
-0.3448165953159332,
-0.47260338068008423,
-0.5523179769515991,
-0.15124961733818054,
-0.3927241563796997,
0.43832579255104065,
-0.4608006179332733,
0.09282679855823517,
0.17134124040603638,
-0.06449733674526215,
0.3167237639427185,
0.3184454143047333,
-0.12116042524576187,
0.15717825293540955,
0.32964006066322327,
0.17439965903759003,
0.8381075263023376,
0.1351994276046753,
0.349036306142807,
0.5315445065498352,
-0.15143370628356934,
0.8014782071113586,
-0.31274527311325073,
-0.2992551028728485,
-1.0112112760543823,
-0.07387705892324448,
-0.05117747560143471,
-0.03811795264482498,
0.017670001834630966,
1.178063988685608,
-0.7437264323234558,
0.2655861973762512,
-0.07726641744375229,
-0.08992421627044678,
-0.17515157163143158,
0.34112584590911865,
-0.3307954967021942,
0.27304163575172424,
0.5385715365409851,
0.5186718702316284,
-0.24655242264270782,
0.7161462903022766,
0.6449928879737854,
-0.6759499907493591,
0.3016217350959778,
0.5014032125473022,
-0.12013238668441772,
0.08440214395523071,
0.503189742565155,
-0.41394689679145813,
-0.42977672815322876,
0.27426889538764954,
0.24855245649814606,
-0.34052547812461853,
-0.2652667462825775,
0.5429741144180298,
-0.005300103221088648,
-0.2615536153316498,
-0.31325051188468933,
0.16047872602939606,
-0.3764224350452423,
-0.18285149335861206,
-0.18750450015068054,
-0.24900418519973755,
0.07673215866088867,
-0.09567930549383163,
0.08573828637599945,
-0.09316190332174301,
-0.1406012624502182,
-0.16027656197547913,
-0.2632159888744354,
-0.09626562893390656,
0.09453091770410538,
-0.022912636399269104,
0.1398632526397705,
-0.6917479038238525,
0.33680200576782227,
0.9846690893173218,
-0.13251632452011108,
-0.06941866129636765,
-0.4779888391494751,
0.4418971836566925,
-0.2711597681045532,
-0.617699921131134,
-0.2509470582008362,
0.3081896901130676,
0.060505617409944534,
0.13945895433425903,
-0.23581017553806305,
-0.2105550915002823,
0.4063682556152344,
-0.3457764685153961,
-0.38879093527793884,
-0.3589704632759094,
-0.306805819272995,
0.19582995772361755,
0.18998833000659943,
-0.3278862535953522,
0.3433104455471039,
-0.12699779868125916,
0.2166062891483307,
0.329555869102478,
-0.6705336570739746,
-0.4115837514400482,
0.32348400354385376,
0.08158622682094574,
0.17144523561000824,
0.0030784630216658115,
-0.21087224781513214,
-0.7071520686149597,
-0.30946025252342224,
0.02916407771408558,
0.35526612401008606,
0.2926466166973114,
-0.36427992582321167,
0.13097018003463745,
-0.23709732294082642,
-0.47129935026168823,
-0.14448727667331696,
0.21523050963878632,
-0.4059625566005707,
0.3415270745754242,
0.48186561465263367,
-0.4670409858226776,
0.33571022748947144,
-0.06566625088453293,
-0.30882248282432556,
-0.2585243582725525,
-0.15667766332626343,
0.23522265255451202,
0.0013676625676453114,
0.1365881860256195,
-0.7077366709709167,
-0.02582055889070034,
0.7990161776542664,
-0.01983797736465931,
0.20404084026813507,
-0.36874330043792725,
-0.353833943605423,
0.21785390377044678,
0.34503865242004395,
0.03022005595266819,
-0.199144184589386,
-0.24338550865650177,
-0.2730754017829895,
-0.35089462995529175,
0.7351349592208862,
0.2665462791919708,
-0.8599392175674438,
0.0478353425860405,
0.2180163562297821,
0.03775997459888458,
-0.37630313634872437,
0.29515039920806885,
0.27014341950416565,
-0.36378803849220276,
-0.6548203825950623,
0.31003516912460327,
0.013931158930063248,
0.06101158633828163,
0.29745328426361084,
-0.0027374885976314545,
0.37676534056663513,
-0.3784884214401245,
-0.535817563533783,
-0.15406133234500885,
-0.0049308957532048225,
0.3812132477760315,
-0.44890096783638,
-0.4904860258102417,
0.20936882495880127,
-0.42617225646972656,
-0.264415442943573,
-0.23297880589962006,
0.12000872939825058,
0.5202345252037048,
0.04594040289521217,
-0.10625719279050827,
-0.11044245213270187,
-0.28529250621795654,
-0.4180854856967926,
-0.03244446590542793,
0.09644167125225067,
-0.5548251271247864,
-0.06486199051141739,
0.08184139430522919,
-0.12623213231563568,
-0.6937591433525085,
-0.3653883635997772,
-0.13594591617584229,
-0.3776673376560211,
-0.05643590912222862,
-0.2935411036014557,
0.7679236531257629,
0.7014668583869934,
0.5033270120620728,
0.4254845678806305,
-0.3327562212944031,
-0.01508629322052002,
-0.30672144889831543,
0.4686664044857025,
0.07403832674026489,
-0.31259050965309143,
0.1488512009382248,
-0.35176417231559753,
0.31164035201072693,
-0.4168105721473694,
0.051057346165180206,
-0.4675486981868744,
0.20425432920455933,
-0.36916470527648926,
-0.188001349568367,
0.1725156158208847,
-0.6084327697753906,
-0.30997756123542786,
-0.12027617543935776,
0.3294125199317932,
0.16109389066696167,
0.251965194940567,
0.1615591049194336,
-0.5491536855697632,
-0.517376720905304,
0.8355868458747864,
0.40460652112960815,
-0.4000909626483917,
0.059909697622060776,
0.29133927822113037,
0.19906897842884064,
0.5563652515411377,
-0.15955451130867004,
0.16298802196979523,
0.1883012056350708,
-0.07815893739461899,
0.3621082007884979,
0.4768114387989044,
-0.3842814564704895,
0.5795807838439941,
-0.10904952138662338,
-0.246863454580307,
0.2809735834598541,
-0.23046673834323883,
0.2521609663963318,
0.24443286657333374,
0.2241995483636856,
-0.0612981840968132,
-0.8249420523643494,
0.4636530578136444,
-0.595051646232605,
0.19828389585018158,
-0.1829003244638443,
0.947316586971283,
0.8037214279174805,
0.42114561796188354,
-0.38897159695625305,
0.11620272696018219,
0.08652564883232117,
0.1268138885498047,
0.21242377161979675,
-0.3425895571708679,
-0.2714390754699707,
0.022827018052339554,
0.9827478528022766,
-0.026402801275253296,
-0.025296535342931747,
0.18734845519065857,
-0.1521025151014328,
0.19150327146053314,
0.18668879568576813,
0.36579039692878723,
0.03447216749191284,
0.06561679393053055,
0.30412572622299194,
-0.08788234740495682,
-0.07781043648719788,
0.2161962389945984,
-0.22921952605247498,
0.03866814449429512,
0.40258222818374634,
-0.3570435047149658,
-0.22935639321804047,
0.012690134346485138,
0.26257166266441345,
0.022254692390561104,
0.06284511834383011,
0.499760240316391,
0.11377980560064316,
-0.03297044336795807,
0.5926690101623535,
0.1785573959350586,
-0.11654779314994812,
-0.2759619951248169,
-0.10893873870372772,
-0.5565631985664368,
-0.07951392233371735,
0.5046031475067139,
0.4775291979312897,
0.007771430537104607,
-0.26427769660949707,
0.01702742464840412,
-0.15604522824287415,
0.3873232901096344,
-0.5157874226570129,
-0.14290818572044373,
-0.1912960559129715,
-0.30981168150901794,
-0.3260504901409149,
-0.1441614031791687,
-0.685293436050415,
0.06466254591941833,
0.13508036732673645,
0.03868485987186432,
0.11429870873689651,
-0.3810868263244629,
-0.19036318361759186,
0.33703839778900146,
0.1628742665052414,
-0.31012141704559326,
0.359589159488678,
0.6306279301643372,
-0.019750522449612617,
0.2986832559108734,
-0.2580835521221161,
0.2980494201183319,
-0.6478938460350037,
0.3125193119049072,
-0.5132312774658203,
0.45598670840263367,
-0.2918606698513031,
0.19923603534698486,
-0.6202296018600464,
0.23605869710445404,
0.6242322325706482,
0.49062174558639526,
-0.19935984909534454,
0.22935430705547333,
-0.20860542356967926,
0.1390506625175476,
0.20904549956321716,
-0.5685976147651672,
0.0285488311201334,
-0.695147693157196,
-0.0028872950933873653,
-0.42937493324279785,
0.4315568506717682,
-0.044577013701200485,
-0.2831961512565613,
0.04910670220851898,
0.347776859998703,
0.5860186219215393,
-0.11370497941970825,
0.5277217030525208,
-0.33682531118392944,
0.28994718194007874,
-0.4931178689002991,
0.32596829533576965,
-0.7656474113464355,
-0.07636436074972153,
0.16936412453651428,
0.38411185145378113,
0.5192101001739502,
0.3325546383857727,
0.17322532832622528,
-0.41555899381637573,
0.3571760356426239,
0.4091470539569855,
-0.013811085373163223,
-0.12684202194213867,
-0.056638143956661224,
-0.3460941016674042,
-0.4960947632789612,
0.4167918264865875,
-0.12924133241176605,
-0.029061002656817436,
-0.030393606051802635,
0.25254061818122864,
-0.16929517686367035,
0.27641281485557556,
0.09712371230125427,
-0.3327610194683075,
-0.11692135035991669,
-0.11301358789205551
] |
National public health institutes will play a key role in implementation of the revised International Health Regulations. | [
-0.009508662857115269,
0.037863411009311676,
0.005843104794621468,
0.06561906635761261,
0.08100113272666931,
0.05890512838959694,
0.021856488659977913,
0.005926394835114479,
-0.03770327940583229,
-0.01636115461587906,
0.007342627737671137,
0.043017398566007614,
0.03348226845264435,
-0.025945015251636505,
-0.06582058221101761,
-0.025334475561976433,
0.05020194873213768,
0.023779062554240227,
0.017955727875232697,
0.05609070137143135,
-0.11098828166723251,
0.07095690071582794,
0.02246832102537155,
0.05366118997335434,
0.03727434203028679,
-0.030217431485652924,
-0.03777782991528511,
0.020002083852887154,
-0.059138428419828415,
0.017138836905360222,
0.0608619786798954,
-0.0036483719013631344,
0.09402017295360565,
-0.04077703878283501,
-0.034041620790958405,
-0.04626082256436348,
-0.00864527840167284,
0.020423591136932373,
-0.045561645179986954,
-0.014413099735975266,
0.044266000390052795,
-0.0202031247317791,
0.01060872245579958,
-0.0122141782194376,
-0.003534757997840643,
-0.025411300361156464,
-0.015322893857955933,
-0.0307859405875206,
0.032774899154901505,
0.03264562785625458,
0.005285752937197685,
-0.06660711020231247,
-0.02069036476314068,
0.11858968436717987,
-0.01975656859576702,
0.045437708497047424,
0.033382318913936615,
0.050742052495479584,
-0.03408857807517052,
-0.03393654525279999,
0.040441080927848816,
-0.08367833495140076,
0.014946567825973034,
0.06201331317424774,
0.05329867824912071,
-0.06133391708135605,
-0.03801318630576134,
-0.02713429182767868,
-0.03833236172795296,
0.04601540416479111,
0.03501880541443825,
0.045723263174295425,
-0.0035534242633730173,
-0.10861122608184814,
0.015307668596506119,
0.02025585249066353,
0.014182236976921558,
0.03197557479143143,
-0.009676900692284107,
-0.01989767700433731,
-0.05059942230582237,
0.009048930369317532,
-0.07552068680524826,
-0.014098846353590488,
0.09772256016731262,
0.046129290014505386,
0.004874959122389555,
-0.02863239124417305,
0.0195689145475626,
0.01314553339034319,
0.031219763681292534,
0.06914324313402176,
-0.07599317282438278,
-0.04929283633828163,
-0.06990864127874374,
-0.0026980177499353886,
0.00799631979316473,
-0.03641853481531143,
0.055290982127189636,
0.0028313561342656612,
-0.034497298300266266,
0.04243359714746475,
0.03049418516457081,
-0.029010595753788948,
-0.008685004897415638,
0.004261336755007505,
0.0016546520637348294,
0.05547752231359482,
-0.09964728355407715,
0.0028553991578519344,
-0.018448101356625557,
0.012573870830237865,
-0.046582404524087906,
0.05180824175477028,
-0.052295126020908356,
-0.011586878448724747,
0.007245240733027458,
0.08633267134428024,
0.06086054816842079,
-0.04326430708169937,
0.02436581440269947,
-0.026808016002178192,
0.018137197941541672,
0.016227571293711662,
-0.004616099875420332,
0.03837322071194649,
-0.032610420137643814,
0.06620483845472336,
-0.11821556091308594,
0.04516361281275749,
-0.009970836341381073,
0.003859011922031641,
0.0027454441878944635,
-0.01779542677104473,
0.03886333853006363,
0.011968604288995266,
-0.029015205800533295,
0.011245625093579292,
0.002544874558225274,
0.022455431520938873,
0.01898297667503357,
0.029776068404316902,
-0.028190840035676956,
0.016247473657131195,
0.05289439111948013,
0.00739034079015255,
0.013236623257398605,
-0.022744806483387947,
-0.05088941752910614,
-0.019329719245433807,
0.041918203234672546,
-0.045415960252285004,
0.02173616737127304,
-0.06512422114610672,
0.046118270605802536,
0.11009950935840607,
-0.035281844437122345,
-0.06549752503633499,
-0.05648120865225792,
0.05001002922654152,
0.03378039970993996,
-0.07448241114616394,
0.03507500886917114,
0.019481098279356956,
0.05562547594308853,
0.003145851893350482,
0.020704491063952446,
-0.02673405408859253,
0.017439085990190506,
0.009276563301682472,
-0.053540781140327454,
0.013250401243567467,
0.004156155977398157,
0.018437616527080536,
0.04481125995516777,
-0.05994318425655365,
-0.008337331004440784,
0.016466578468680382,
-0.012995579279959202,
0.06400850415229797,
0.08336134999990463,
0.04802979156374931,
0.017513029277324677,
0.04586730897426605,
0.0002305399248143658,
-0.00811217725276947,
0.06822534650564194,
-0.018856525421142578,
-0.01115455012768507,
0.020479878410696983,
-0.05590897426009178,
-0.04462113603949547,
-0.0754680410027504,
-0.025689227506518364,
-0.005183284170925617,
0.014183714054524899,
0.09952755272388458,
0.033922288566827774,
0.05940524488687515,
0.00022160803200677037,
-0.021676845848560333,
0.014124182052910328,
0.1164637878537178,
-0.05521015077829361,
-0.07882659882307053,
0.07146147638559341,
-0.043154750019311905,
-0.036020975559949875,
0.027904711663722992,
0.020359529182314873,
0.000773018051404506,
-0.12984484434127808,
-0.03433770313858986,
-0.04545445367693901,
-0.001549441716633737,
0.08335668593645096,
-0.06963703036308289,
-0.025658993050456047,
0.04930877313017845,
-0.04329730197787285,
-0.038847897201776505,
0.10648252815008163,
-0.0040382519364356995,
-0.03692951425909996,
0.06353013962507248,
-0.05210067331790924,
0.02600463666021824,
0.040459875017404556,
0.02355869859457016,
-0.006952265277504921,
-0.05343359336256981,
-0.014120250940322876,
-0.02794164977967739,
-0.04944658279418945,
0.13158029317855835,
0.07950977236032486,
0.02699444256722927,
-0.020072251558303833,
0.04803844913840294,
-0.04379378631711006,
0.054518185555934906,
-0.039310406893491745,
0.12503381073474884,
0.06741327792406082,
0.018550937995314598,
-0.03545684367418289,
-0.013409513980150223,
0.02313021384179592,
0.04119503125548363,
0.06093360483646393,
0.021110298112034798,
0.02661166340112686,
0.00911780446767807,
-0.061401497572660446,
0.07231538742780685,
0.032585639506578445,
-0.019770996645092964,
-0.004465499427169561,
0.038825396448373795,
0.019869394600391388,
0.007657477166503668,
-0.0011047690641134977,
0.013777167536318302,
-0.048849962651729584,
0.0235211793333292,
0.0035600720439106226,
-0.001335327629931271,
-0.002689154352992773,
-0.00041655180393718183,
-0.00882424134761095,
0.02871757000684738,
-0.004232213366776705,
-0.005233995616436005,
-0.07963592559099197,
-0.025359483435750008,
0.022449715062975883,
0.07752710580825806,
0.0442701056599617,
-0.14553509652614594,
0.019656313583254814,
0.06003601849079132,
-0.0739457830786705,
0.0030236663296818733,
-0.06044050306081772,
0.013723566196858883,
-0.028583316132426262,
-0.10274405777454376,
0.06288254261016846,
-0.0002845972776412964,
-0.01720781810581684,
-0.027592862024903297,
-0.0645637959241867,
-0.049779295921325684,
0.009352033957839012,
-0.03142502158880234,
0.04187166318297386,
-0.01047996524721384,
0.061193715780973434,
0.04891010373830795,
-0.05498694255948067,
-0.06451738625764847,
-0.07869202643632889,
0.033434852957725525,
-0.03734196722507477,
-0.004860421642661095,
0.04285715892910957,
-0.02847191132605076,
-0.048524510115385056,
0.0163012333214283,
0.02263762801885605,
-0.020472081378102303,
-0.049893759191036224,
0.05774402245879173,
0.04527783766388893,
0.050022855401039124,
0.04130885750055313,
0.02106962352991104,
0.0029460780788213015,
0.009355905465781689,
0.028809433802962303,
0.06895733624696732,
0.0019326447509229183,
0.0413595587015152,
-0.005580258090049028,
-0.004620794206857681,
-0.037317320704460144,
0.0512508787214756,
-0.024220526218414307,
-0.059978559613227844,
-0.07665689289569855,
-0.022045422345399857,
-0.030563533306121826,
-0.004931041970849037,
0.017024867236614227,
0.06334824115037918,
0.027714891359210014,
-0.02779456228017807,
-0.005789515562355518,
-0.0256753321737051,
0.03892849385738373,
0.005311486776918173,
-0.05090805143117905,
0.0433645024895668,
0.061308134347200394,
-0.03460827097296715,
-0.012870057485997677,
-0.00791954156011343,
0.024208908900618553,
-0.00589614175260067,
-0.03947574272751808,
0.015569635666906834,
-0.02545260637998581,
0.02552390843629837,
-0.04819836467504501,
-0.003512443508952856,
0.010564581491053104,
-0.06015903130173683,
0.05757540836930275,
0.03640051186084747,
0.03281646594405174,
-0.029290568083524704,
0.025586159899830818,
-0.027460122480988503,
0.01664971560239792,
-0.004764835815876722,
0.0108180558308959,
-0.00022936341702006757,
0.01231361273676157,
-0.04382747784256935,
-0.026427127420902252,
-0.03528749942779541,
0.03433893620967865,
0.025155961513519287,
-0.08051324635744095,
0.026662182062864304,
-0.015058967284858227,
-0.02133774943649769,
-0.05852198600769043,
0.01656150445342064,
0.03491375222802162,
-0.039506133645772934,
-0.0326148122549057,
-0.02005886286497116,
-0.012475726194679737,
0.0689845010638237,
0.008470842614769936,
0.05097705498337746,
0.01877986080944538,
0.06152699887752533,
0.050203725695610046,
0.027785981073975563,
0.06355727463960648,
0.02609136886894703,
0.009521433152258396,
-0.01794375851750374,
0.06289846450090408,
-0.03179414942860603,
0.04138033092021942,
-0.03797042742371559,
0.03493736684322357,
0.014982510358095169,
0.033879347145557404,
0.01741967350244522,
0.009763691574335098,
0.01671300269663334,
-0.005755895283073187,
0.011644084006547928,
0.06724988669157028,
0.025364911183714867,
0.081417016685009,
0.04907267168164253,
-0.05647702515125275,
-0.07202325016260147,
-0.013323549181222916,
0.02755719982087612,
0.14408783614635468,
-0.026029687374830246,
-0.022942589595913887,
-0.00007790166273480281,
0.022725971415638924,
0.022565383464097977,
-0.0701199471950531,
0.011705317534506321,
-0.02016959711909294,
-0.0766371414065361,
0.1109536811709404,
-0.045492079108953476,
0.01788935624063015,
-0.0191037580370903,
-0.03487326204776764,
-0.0186087004840374,
-0.025756506249308586,
-0.017380405217409134,
0.007301590871065855,
0.019218647852540016,
-0.0655045360326767,
0.08689916878938675,
0.0031927444506436586,
-0.0074774459935724735,
-0.0025639599189162254,
0.005562964361160994,
-0.044003795832395554,
0.06988105177879333,
0.04521286115050316,
-0.011342223733663559,
-0.040434446185827255,
-0.022444136440753937,
-0.009922357276082039,
-0.012572028674185276,
0.043375298380851746,
0.046416714787483215,
0.03219718113541603,
0.03156986087560654,
0.040829457342624664,
-0.037295643240213394,
0.06626126170158386,
-0.017667539417743683,
0.053671348839998245,
-0.04968215152621269,
-0.007552809547632933,
-0.011761624366044998,
-0.06504612416028976,
0.05721709877252579,
-0.07411419600248337,
-0.029480379074811935,
-0.0495588555932045,
0.007734191603958607,
-0.016941718757152557,
0.020699163898825645,
0.04024386778473854,
-0.06861801445484161,
-0.09860320389270782,
0.0850854218006134,
0.05384989082813263,
-0.0014420863008126616,
0.013409465551376343,
-0.04946965351700783,
-0.02539793960750103,
-0.0639290064573288,
-0.06720253825187683,
0.058341242372989655,
-0.024926036596298218,
-0.06720352917909622,
-0.004411032423377037,
-0.07111755013465881,
0.051050011068582535,
-0.009589949622750282,
-0.03163844719529152,
-0.12012393027544022,
0.06525571644306183,
0.06842470169067383,
-0.013587677851319313,
0.024708904325962067,
0.02691572904586792,
0.013434088788926601,
0.033128771930933,
-0.022806178778409958,
-0.07341396063566208,
-0.06232614815235138,
-0.03385286405682564,
-0.09787923842668533,
-0.022347256541252136,
0.04497267305850983,
-0.07231415063142776,
0.005506415851414204,
0.019708732143044472,
-0.024469906464219093,
-0.02843376249074936,
-0.009018367156386375,
0.05184352025389671,
-0.01640632562339306,
-0.10377916693687439,
-0.03571321815252304,
-0.016904382035136223,
0.03775221109390259,
-0.052287209779024124,
0.020810306072235107,
0.02526988461613655,
-0.04059433564543724,
0.021023182198405266,
0.06765884160995483,
0.051648687571287155,
-0.08310511708259583,
-0.007322391960769892,
0.031223231926560402,
-0.01856572926044464,
-0.05278109014034271,
-0.03215223550796509,
0.006376304198056459,
0.0111306793987751,
0.019198782742023468,
-0.03649318590760231,
-0.011796373873949051,
-0.04332588613033295,
0.004145890008658171,
-0.018191883340477943,
-0.024981169030070305,
0.046198561787605286,
-0.018799077719449997,
0.07326013594865799,
-0.022558383643627167,
0.03118114545941353,
-0.032888904213905334,
-0.0031222107354551554,
0.07583453506231308,
-0.03734530135989189,
0.06878042221069336,
-0.017521558329463005,
-0.050922930240631104,
0.03199237212538719,
-0.005584869533777237,
0.03164811432361603,
-0.0432048961520195,
0.009617418982088566,
-0.03805903345346451,
-0.07792112976312637,
-0.05400540679693222,
0.059900280088186264,
0.09437239915132523,
-0.015835022553801537,
0.03246865049004555,
-0.022228047251701355,
0.005299984011799097,
0.019938809797167778,
0.008577030152082443,
-0.006182655226439238,
0.06834933161735535,
-0.017959637567400932,
0.0529152974486351,
-0.07294123619794846,
0.010235946625471115,
0.0016486021922901273,
0.028447043150663376,
0.011118120513856411,
-0.029537832364439964,
-0.016756001859903336,
-0.03399762138724327,
-0.058120544999837875,
-0.06353189796209335,
0.04098644480109215,
0.04319765418767929,
0.062903992831707,
0.023428810760378838,
-0.00451565720140934,
-0.021956203505396843,
-0.016600821167230606,
0.005658444948494434,
-0.05718976631760597,
-0.03300091624259949,
0.010796325281262398,
0.04651167243719101,
-0.024711020290851593,
-0.026933491230010986,
-0.0615304596722126,
-0.061438582837581635,
0.021212654188275337,
-0.014447049237787724,
-0.056304432451725006,
0.0032977962400764227,
0.01488527562469244,
0.05221196264028549,
-0.08377759158611298,
0.0071175615303218365,
0.020805882290005684,
-0.043471504002809525,
0.06056906282901764,
0.08781475573778152,
-0.010203170590102673,
0.018153777346014977,
0.033500004559755325,
0.10360024124383926,
-0.008307665586471558,
0.03085956536233425,
-0.04125509038567543,
-0.05757193639874458,
-0.011373341083526611,
0.07659618556499481,
-0.026717446744441986,
0.03700421750545502,
-0.012668118812143803,
-0.06118815764784813,
-0.028248947113752365,
0.010568269528448582,
0.025307102128863335,
0.04547756537795067,
-0.030808059498667717,
0.004842706490308046,
-0.03839868679642677,
0.04438728094100952,
-0.005095386877655983,
0.10776558518409729,
-0.004817229695618153,
0.03209790214896202,
-0.07062909752130508,
0.019171176478266716,
0.033858928829431534,
-0.0018363513518124819,
-0.04918690770864487,
0.010543964803218842,
0.0356789231300354,
0.09261319786310196,
0.03476625308394432,
0.05920128524303436,
0.010920660570263863,
0.07342708110809326,
0.029591906815767288,
-0.02176821418106556,
0.0008085099398158491,
-0.02149648219347,
-0.004967421293258667,
-0.03395145758986473,
-0.02372589521110058,
0.09739778190851212,
0.02852536365389824,
-0.006424590479582548,
0.032501570880413055,
-0.06983727961778641,
0.059818290174007416,
-0.030195612460374832,
0.019661081954836845,
0.014676946215331554,
0.04454599693417549,
0.060535356402397156,
0.001071840524673462,
0.02623877488076687,
0.037624385207891464,
0.05081282928586006,
0.011484288610517979,
0.0271792933344841,
0.005171666853129864,
0.04167366400361061,
-0.053011778742074966,
0.007930443622171879,
-0.030352305620908737,
-0.04206062853336334,
-0.028938762843608856,
-0.018853606656193733,
-0.0020966718439012766,
-0.08020801842212677,
0.031172366812825203,
-0.0027033218648284674,
0.011259272694587708,
-0.05026073381304741,
0.0051474180072546005,
-0.014600416645407677,
-0.028550835326313972,
-0.013699447736144066,
-0.00765893654897809,
0.12992720305919647,
-0.00367462239228189,
-0.04540465027093887,
0.012959792278707027,
-0.02064230479300022,
0.04095060005784035,
0.031915172934532166,
0.08658187091350555,
0.02291594259440899,
0.017719866707921028,
0.014134472236037254,
-0.003910533618181944,
0.022660961374640465,
0.03358454629778862,
0.016849908977746964,
0.034427378326654434,
0.019564451649785042,
0.16432219743728638,
-0.07398894429206848,
0.008309654891490936,
0.016970409080386162,
-0.0348283089697361,
0.021521568298339844,
-0.03521192446351051,
0.05800800025463104,
-0.006296219304203987,
0.02964647486805916,
-0.031676746904850006,
0.01718680001795292,
-0.04133101925253868,
0.012246539816260338,
-0.017214220017194748,
0.01033218763768673,
0.013519834727048874,
-0.01767875626683235,
-0.05667872726917267,
-0.0639423206448555,
-0.018332529813051224,
-0.05797433480620384,
-0.02068861573934555,
0.04297671094536781,
0.03457199037075043,
-0.017733590677380562,
-0.07146134227514267,
0.07023153454065323,
-0.007110103964805603,
-0.011066113598644733,
-0.06195170059800148,
0.07049988955259323,
-0.0193235594779253,
-0.06416025012731552,
0.09277205914258957,
-0.06320147961378098,
-0.003104886505752802,
-0.02470008097589016,
0.022922569885849953,
-0.06669288128614426,
0.01688835211098194,
0.06637478619813919,
0.031812962144613266,
0.01087950263172388,
-0.02038721553981304,
0.020997952669858932,
0.014018649235367775,
-0.008528278209269047,
0.06720976531505585,
0.009643841534852982,
-0.06888440251350403,
0.033158909529447556,
0.035568300634622574,
-0.07476134598255157,
-0.01940385065972805,
-0.060188233852386475,
-0.03806367889046669,
-0.07370207458734512,
0.002594094490632415,
-0.012487412430346012,
0.011309320107102394,
-0.04576082527637482,
-0.03408188000321388
] | [
0.8060250282287598,
-0.15089435875415802,
0.10159897059202194,
0.12511496245861053,
-0.04983430728316307,
0.06998089700937271,
0.04518124461174011,
0.11068950593471527,
-0.24292738735675812,
-0.5721675157546997,
-0.20940177142620087,
0.481878399848938,
0.1980637162923813,
0.015406584367156029,
0.18232806026935577,
0.09256789088249207,
0.2804255485534668,
0.34504297375679016,
0.5239547491073608,
-0.26602447032928467,
-0.648494303226471,
-0.2156042754650116,
0.16915997862815857,
0.0660904049873352,
0.2895805239677429,
0.12744536995887756,
0.5282368659973145,
0.03266804665327072,
-0.14437875151634216,
0.015397069975733757,
0.39026495814323425,
-0.2627333402633667,
0.15554118156433105,
0.4035719037055969,
0.048767559230327606,
-0.17999549210071564,
-0.07072528451681137,
-0.1832728236913681,
0.13088519871234894,
-0.5476460456848145,
-0.4835224747657776,
-0.3578919768333435,
-0.21691663563251495,
0.37972012162208557,
-0.2786714434623718,
-0.781201958656311,
-0.9459657669067383,
0.4374532699584961,
0.0025743062142282724,
0.46424561738967896,
-0.5440801382064819,
-0.049623407423496246,
0.10599437355995178,
0.0759032592177391,
-0.13967834413051605,
0.296369343996048,
-0.1619337797164917,
0.26771509647369385,
-0.414357453584671,
-0.3567351996898651,
-0.002134748036041856,
-0.28247886896133423,
0.09537329524755478,
0.25839948654174805,
0.0673385038971901,
0.20523275434970856,
0.20099106431007385,
-0.013356653973460197,
-0.17425288259983063,
-0.1227143332362175,
-0.4342634677886963,
-0.426624596118927,
-0.39960598945617676,
-0.02750272862613201,
-0.39127129316329956,
-0.3989892899990082,
0.058701615780591965,
-0.23960834741592407,
0.23813976347446442,
-0.035528820008039474,
0.033568125218153,
0.04284185171127319,
0.1699417382478714,
-0.6946902871131897,
0.5116149187088013,
0.35402387380599976,
0.13335487246513367,
0.02987709641456604,
-0.14530161023139954,
0.4457555115222931,
-0.11578629165887833,
-0.1391063928604126,
0.10018971562385559,
0.10648999363183975,
-0.028052909299731255,
0.1793375164270401,
0.4716239273548126,
-0.5911666750907898,
0.10638780146837234,
-0.30186882615089417,
0.2857811152935028,
-0.08265761286020279,
-0.39661258459091187,
-0.3240543603897095,
-0.6563769578933716,
-0.3627346158027649,
0.10229844599962234,
-0.7178227305412292,
-0.5197128057479858,
-0.05867677181959152,
-0.20810897648334503,
-0.023663632571697235,
-0.26970744132995605,
-0.18646465241909027,
-0.2877892553806305,
0.49229636788368225,
0.45440348982810974,
-0.1584382951259613,
-0.34212666749954224,
0.07198946177959442,
0.24594545364379883,
0.1844639778137207,
0.25143855810165405,
0.15399496257305145,
-0.05620310828089714,
0.400371253490448,
0.7081718444824219,
-0.08309495449066162,
0.02894534543156624,
0.2185502052307129,
0.10362133383750916,
0.33903104066848755,
-0.5409460067749023,
-0.47884994745254517,
0.4079890251159668,
-0.7503625750541687,
-0.16562967002391815,
-0.07132302224636078,
0.47422024607658386,
0.0941905826330185,
-0.45990094542503357,
-0.22072620689868927,
-0.13581465184688568,
-0.31712836027145386,
0.1245306208729744,
-0.5367563366889954,
-0.10859004408121109,
-0.42262300848960876,
-0.09305839985609055,
0.04942174628376961,
-0.15200120210647583,
0.17535896599292755,
-0.2792772054672241,
0.44980335235595703,
0.026150664314627647,
0.4139770567417145,
0.4525600075721741,
-0.08590435981750488,
0.3992772400379181,
0.12623915076255798,
0.41441890597343445,
0.10299962013959885,
-0.35323193669319153,
-0.4185342788696289,
-0.31492412090301514,
-0.09700639545917511,
-0.23951953649520874,
0.041676927357912064,
0.5229067802429199,
-0.022655466571450233,
-0.5666646957397461,
-0.22047773003578186,
-0.24635733664035797,
-0.36008480191230774,
0.05861898139119148,
-0.4677172303199768,
-0.018296370282769203,
-0.11370522528886795,
0.02483312599360943,
0.12670907378196716,
-0.43031975626945496,
-0.11069049686193466,
0.21674534678459167,
0.13401740789413452,
0.16065402328968048,
-0.3250460624694824,
0.10206331312656403,
-0.013954086229205132,
0.21594832837581635,
0.0767727792263031,
-0.11608653515577316,
-0.3855842351913452,
0.2662070691585541,
-0.2962970435619354,
1.1473941802978516,
-0.45036056637763977,
0.2537749707698822,
1.2338069677352905,
-0.5807086825370789,
-0.7441257834434509,
-0.04656602442264557,
-0.034493338316679,
0.5603599548339844,
-0.10850890725851059,
-0.901107668876648,
0.1651884764432907,
0.2081109881401062,
-0.12782882153987885,
0.02985478565096855,
-0.2340264469385147,
0.6043137907981873,
-0.28718072175979614,
0.02869732491672039,
-0.4196353256702423,
0.120969757437706,
-0.04823684319853783,
-0.229558527469635,
0.18210993707180023,
0.053697772324085236,
-0.208622008562088,
0.933803141117096,
-0.42260122299194336,
0.4459601938724518,
0.9197969436645508,
0.18318967521190643,
0.007984352298080921,
0.17430110275745392,
0.18425457179546356,
0.27697819471359253,
-0.44799256324768066,
0.4737546145915985,
-0.6459115147590637,
0.3880827724933624,
-0.10021095722913742,
-0.250177264213562,
0.3285464346408844,
-0.5808418393135071,
0.09355966001749039,
0.1915290355682373,
-0.4565977454185486,
-0.15185946226119995,
0.15049216151237488,
-0.3703222870826721,
0.12428649514913559,
0.13235585391521454,
-0.24257270991802216,
-0.5468294024467468,
0.052872028201818466,
-0.24046413600444794,
0.018891295418143272,
0.10520797967910767,
0.11942112445831299,
-0.02275693044066429,
-0.44478270411491394,
0.39923974871635437,
-0.013442677445709705,
0.020711664110422134,
0.1491554230451584,
0.3965078592300415,
-0.3184896409511566,
-0.14284245669841766,
0.15257616341114044,
-0.17898952960968018,
0.41399094462394714,
0.15433312952518463,
-0.6946314573287964,
-0.7212794423103333,
-0.5320137739181519,
-0.10607621818780899,
0.18033818900585175,
0.38947194814682007,
0.38412535190582275,
-0.150382861495018,
-0.2484614998102188,
0.35124677419662476,
-0.5284454822540283,
0.4263475239276886,
1.2205798625946045,
-0.3744391202926636,
0.05549929663538933,
0.2917085289955139,
0.09226430952548981,
0.3573828637599945,
-0.6144421696662903,
-0.2925746440887451,
-0.22386561334133148,
0.0907122790813446,
-0.636399507522583,
-0.4602962136268616,
0.5134740471839905,
-0.5346865057945251,
0.5845814943313599,
-0.05604065582156181,
-0.3594422936439514,
0.0893314927816391,
-0.545894205570221,
-0.37424105405807495,
0.4444330036640167,
0.20034770667552948,
-0.20591427385807037,
-0.3961796462535858,
0.3964153826236725,
0.0901806429028511,
-0.2907406985759735,
-0.0806535854935646,
-0.0028046995867043734,
-0.0015153425047174096,
-0.09068645536899567,
-6.16380500793457,
0.03195374459028244,
-0.2759852707386017,
0.04572122544050217,
0.24223165214061737,
0.03126698359847069,
0.5699896812438965,
-0.11099577695131302,
0.27335986495018005,
-0.12640999257564545,
0.11992693692445755,
0.33990275859832764,
0.6848679184913635,
0.25314944982528687,
-0.5071281790733337,
0.4839569628238678,
0.37312978506088257,
-0.1700962334871292,
0.07953586429357529,
0.5036793351173401,
0.3993566334247589,
-0.3375367224216461,
0.3064904808998108,
0.2217666655778885,
0.46709781885147095,
-0.23127050697803497,
-1.2346982955932617,
0.24380391836166382,
-0.06890706717967987,
-0.6213123798370361,
0.49338847398757935,
-0.09057052433490753,
0.32167914509773254,
-0.21342360973358154,
0.12406548857688904,
-0.16408805549144745,
-0.0963420420885086,
0.3058145344257355,
-0.06970613449811935,
-0.5077261328697205,
-0.3081890642642975,
0.17621852457523346,
-0.23488938808441162,
0.06634781509637833,
0.05264004319906235,
-0.10218888521194458,
0.21501311659812927,
0.20192235708236694,
-0.32643193006515503,
0.7004241347312927,
0.0019196028588339686,
0.19482304155826569,
0.28559502959251404,
0.14394035935401917,
-0.2941249907016754,
-0.08718997240066528,
-0.1960153430700302,
0.6930468678474426,
-0.34891679883003235,
-0.11020146310329437,
-0.04681998863816261,
-0.4607233703136444,
-0.09401493519544601,
-0.4916498064994812,
0.1045510545372963,
0.26675543189048767,
-0.686968982219696,
-0.643886923789978,
0.42782413959503174,
0.1287115514278412,
-0.14621055126190186,
0.28807252645492554,
-0.005098246969282627,
-0.6494691371917725,
-0.2608756422996521,
-0.9888365268707275,
0.2653106451034546,
-0.03930794075131416,
0.14860767126083374,
-0.44001439213752747,
-0.5556061267852783,
-0.07896848767995834,
0.010767047293484211,
0.30387961864471436,
0.36949464678764343,
-0.1527523547410965,
0.29703670740127563,
-0.26262760162353516,
0.2158667892217636,
-0.11369407922029495,
0.6794791221618652,
-0.4569867253303528,
0.8093807697296143,
0.09928370267152786,
0.22319835424423218,
0.5689598917961121,
0.2948210835456848,
0.43290984630584717,
-0.41031622886657715,
-0.5613129138946533,
0.19567109644412994,
0.3261890709400177,
-0.2142513543367386,
-0.6425127387046814,
-0.028824856504797935,
0.10924961417913437,
0.09794364124536514,
0.4168795645236969,
0.45475903153419495,
-1.0100826025009155,
-0.21427632868289948,
-0.2625347971916199,
-0.4204409718513489,
-0.36690253019332886,
0.08625899255275726,
-0.3612864017486572,
-0.16009652614593506,
0.22226141393184662,
0.6093238592147827,
0.4300522804260254,
0.10711846500635147,
0.5998619794845581,
0.47045502066612244,
0.0387527197599411,
0.34265631437301636,
-0.12569254636764526,
-0.03130350261926651,
-0.3138406574726105,
0.08055771142244339,
0.005084283649921417,
0.4622545540332794,
0.48751312494277954,
0.08801919221878052,
-0.5719411373138428,
0.4737921953201294,
0.027505606412887573,
-0.1791861206293106,
0.6237618327140808,
0.09239228069782257,
0.08881868422031403,
0.1270950436592102,
0.6565542221069336,
-0.02663593366742134,
0.41630819439888,
0.6048413515090942,
-0.18687888979911804,
-0.372439980506897,
0.3909169137477875,
-0.22007575631141663,
0.1164340227842331,
0.18074946105480194,
-0.05585821717977524,
0.12125072628259659,
-0.17685620486736298,
-0.18416090309619904,
-0.02934984117746353,
0.8141571283340454,
-0.21408171951770782,
-0.02775570936501026,
-0.4244338274002075,
-0.07685309648513794,
-0.45847541093826294,
-0.9260175228118896,
0.3774338960647583,
0.6187646389007568,
0.20040564239025116,
-0.39627113938331604,
-0.2011648267507553,
-0.09616640955209732,
0.46518343687057495,
0.18706725537776947,
0.13808417320251465,
-0.2675081491470337,
0.06052345782518387,
-0.5408007502555847,
-0.07340585440397263,
-0.06701221317052841,
0.9507098197937012,
-0.03617068752646446,
0.20157717168331146,
0.1074102371931076,
-0.5883820652961731,
-0.257213294506073,
0.12177111953496933,
0.18536998331546783,
0.04676871746778488,
-0.2593569755554199,
0.043908651918172836,
0.00537436967715621,
0.16019919514656067,
0.8400143980979919,
-0.23285377025604248,
0.5129889249801636,
0.13025183975696564,
-0.13071663677692413,
-0.30768558382987976,
-0.6700572967529297,
0.293753981590271,
-0.08007469773292542,
-0.1625872701406479,
0.1977417916059494,
0.4599801301956177,
-0.854775607585907,
0.15320631861686707,
-0.03336875140666962,
-0.1841573864221573,
-0.10615525394678116,
0.1955191045999527,
0.19710911810398102,
0.05335002392530441,
-0.28202977776527405,
-0.06510628759860992,
0.05009524151682854,
0.33709630370140076,
-0.2163756638765335,
-0.2682616412639618,
-0.33131149411201477,
-0.6028202176094055,
-0.11077242344617844,
-0.1963040977716446,
0.4872635006904602,
-0.19702039659023285,
0.08742848038673401,
-0.11699092388153076,
0.05294030159711838,
0.050547100603580475,
0.35724371671676636,
-0.634705662727356,
0.0676683560013771,
0.1623755544424057,
-0.17347198724746704,
0.2611469030380249,
0.42171284556388855,
-0.05235850811004639,
-0.15896308422088623,
-0.2145417332649231,
-0.16298606991767883,
0.17126905918121338,
0.17403139173984528,
0.15250377357006073,
-0.3089781105518341,
0.5143116116523743,
-0.27403587102890015,
-0.9721276164054871,
-0.42599764466285706,
0.09161929786205292,
0.40076544880867004,
-0.35560479760169983,
-0.09820418059825897,
0.16926419734954834,
0.28854548931121826,
-0.5756509900093079,
-0.03774318844079971,
-0.5565055012702942,
0.04100189357995987,
0.6818978190422058,
-0.293556272983551,
0.04521440714597702,
-0.1316225528717041,
-0.1789204478263855,
-0.1166606992483139,
-0.43775203824043274,
-0.09218264371156693,
-0.05805312097072601,
0.43449658155441284,
-0.584915280342102,
-0.46667903661727905,
-0.47343313694000244,
0.05287846550345421,
-0.7809983491897583,
-0.13586002588272095,
-0.29182112216949463,
0.48830121755599976,
0.14599952101707458,
0.828872799873352,
-0.27602386474609375,
-0.3803146481513977,
0.1016518697142601,
0.13063685595989227,
-0.1078471913933754,
0.1725815087556839,
0.012092594988644123,
0.08103866875171661,
-0.19936230778694153,
0.5005768537521362,
-0.7944968342781067,
-0.21696487069129944,
-0.01055883802473545,
-0.3111509680747986,
-0.3870469629764557,
-0.17785978317260742,
-0.25089579820632935,
-0.3405807912349701,
-0.11262734234333038,
-0.3173946738243103,
0.4873986840248108,
0.5357205271720886,
0.4210645854473114,
-0.08179197460412979,
-0.06231604889035225,
-0.008766904473304749,
0.6372279524803162,
0.14556659758090973,
0.069970041513443,
0.08851286768913269,
0.13304001092910767,
0.19652675092220306,
0.19608426094055176,
-0.4431127905845642,
0.012755134142935276,
-0.041138242930173874,
-0.41418567299842834,
0.978975772857666,
0.8417636752128601,
-0.5004234910011292,
0.1084662452340126,
-0.4225061535835266,
-0.522996723651886,
0.3257888853549957,
0.23844704031944275,
0.10995073616504669,
0.3483240604400635,
0.18394681811332703,
0.2217305451631546,
-0.0330728217959404,
0.41411373019218445,
0.1266813427209854,
0.09604474157094955,
0.30933842062950134,
0.2975281774997711,
0.3095638155937195,
0.49943509697914124,
0.09854461252689362,
-0.15519526600837708,
-0.0933881476521492,
-0.1497073918581009,
0.21696539223194122,
-0.24912430346012115,
-0.3202607035636902,
0.0560624860227108,
0.8462456464767456,
0.2182377129793167,
0.017784973606467247,
0.00989033468067646,
-0.15316003561019897,
0.6287168264389038,
0.021404128521680832,
0.2916242182254791,
-0.006955393124371767,
0.3885027766227722,
0.2620091140270233,
-0.15624095499515533,
-0.04767148941755295,
0.6041786074638367,
-0.3267621695995331,
-0.018337516114115715,
-0.14780253171920776,
-0.18570265173912048,
0.3063754737377167,
-0.2832619845867157,
-0.35872822999954224,
0.3084518611431122,
-0.06076207384467125,
0.1867932379245758,
0.24026049673557281,
0.341782808303833,
0.7149670720100403,
0.1267262101173401,
0.12917694449424744,
-0.16445313394069672,
-0.25763261318206787,
-0.09125296771526337,
-0.39482471346855164,
0.20485447347164154,
0.10129237920045853,
-0.7129354476928711,
-0.16905677318572998,
-0.39072921872138977,
0.14122343063354492,
0.2168341428041458,
0.021282849833369255,
0.13952118158340454,
-0.11050362139940262,
-0.89235919713974,
-0.2911168038845062,
0.6374507546424866,
-0.6905843615531921,
0.23870092630386353,
0.11581902951002121,
0.21836097538471222,
-0.21141497790813446,
0.03556070849299431,
0.3484176993370056,
0.4679746627807617,
0.0743386298418045,
-0.020350217819213867,
0.5256929993629456,
0.6372246146202087,
0.1305667906999588,
0.06529593467712402,
-0.11138208210468292,
0.29818591475486755,
0.12067246437072754,
0.33811742067337036,
0.3744033873081207,
0.24773062765598297,
0.09610044211149216,
0.04488201066851616,
-0.06524857878684998,
0.0839829072356224,
0.5107718110084534,
0.328444242477417,
-0.1521826982498169,
0.039469026029109955,
-0.2476545125246048,
0.7239852547645569,
0.43752148747444153,
-0.19593435525894165,
0.034652531147003174,
-0.3873578608036041,
-0.1120382696390152,
-0.418854683637619,
-0.03612196445465088,
0.10730127990245819,
0.15793870389461517,
-0.3549747169017792,
0.5051418542861938,
0.4722442626953125,
-0.21728958189487457,
0.8977136015892029,
-0.5077090859413147,
-0.40107235312461853,
-0.2975124716758728,
-0.1946600079536438,
-0.7265864610671997,
0.14875908195972443,
0.24192200601100922,
0.00039110370562411845,
0.0039626979269087315,
-0.380583792924881,
-0.468753844499588,
-0.08342702686786652,
0.39315977692604065,
0.4128395617008209,
0.17146681249141693,
-0.1830262988805771,
0.24610552191734314,
-0.1424759477376938,
-0.8037635684013367,
0.5960273146629333,
-0.2363336682319641,
-0.2702209949493408,
0.32141801714897156,
-0.39192312955856323,
-0.4593204855918884,
-0.3638078272342682,
0.7761244177818298,
-0.24883441627025604,
0.3347760736942291,
0.41003814339637756
] |
The dynamics of infectious diseases spread via direct person-to-person transmission (such as influenza, smallpox, HIV/AIDS, etc.) depends on the underlying host contact network. Human contact networks exhibit strong community structure. Understanding how such community structure affects epidemics may provide insights for preventing the spread of disease between communities by changing the structure of the contact network through pharmaceutical or non-pharmaceutical interventions. We use empirical and simulated networks to investigate the spread of disease in networks with community structure. We find that community structure has a major impact on disease dynamics, and we show that in networks with strong community structure, immunization interventions targeted at individuals bridging communities are more effective than those simply targeting highly connected individuals. Because the structure of relevant contact networks is generally not known, and vaccine supply is often limited, there is great need for efficient vaccination algorithms that do not require full knowledge of the network. We developed an algorithm that acts only on locally available network information and is able to quickly identify targets for successful immunization intervention. The algorithm generally outperforms existing algorithms when vaccine supply is limited, particularly in networks with strong community structure. Understanding the spread of infectious diseases and designing optimal control strategies is a major goal of public health. Social networks show marked patterns of community structure, and our results, based on empirical and simulated data, demonstrate that community structure strongly affects disease dynamics. These results have implications for the design of control strategies. | [
0.0011233845725655556,
0.011159168556332588,
-0.010648228228092194,
0.01082731131464243,
0.014862172305583954,
-0.03401653468608856,
0.011234542354941368,
-0.0025257510133087635,
-0.01323515921831131,
-0.029297294095158577,
-0.012192066758871078,
0.020608939230442047,
0.002557065337896347,
0.029947619885206223,
0.028986835852265358,
-0.007115568965673447,
0.007498213090002537,
0.001009737141430378,
0.011136374436318874,
-0.026237986981868744,
0.01070647407323122,
0.018111199140548706,
0.01108909398317337,
0.0021538338623940945,
0.001300764735788107,
0.015305244363844395,
0.01090654730796814,
-0.03603599965572357,
-0.025374414399266243,
0.010421219281852245,
-0.013468827120959759,
0.006553144659847021,
-0.0052849305793643,
0.02819656766951084,
0.001283775083720684,
-0.013119050301611423,
0.001026491285301745,
0.03747523948550224,
0.011903014034032822,
-0.0036351161543279886,
0.012263338081538677,
-0.006799936760216951,
0.009892203845083714,
-0.010541070252656937,
-0.007675897795706987,
0.010530663654208183,
-0.0025593831669539213,
0.017158647999167442,
-0.0052392068319022655,
0.01167358085513115,
-0.0018957171123474836,
0.0018317801877856255,
-0.004355572629719973,
-0.01004074327647686,
-0.007420234382152557,
0.03119323030114174,
0.024023430421948433,
-0.014313260093331337,
-0.02464677393436432,
-0.003953580278903246,
0.0074625881388783455,
0.007251140661537647,
-0.0015555417630821466,
-0.01596863567829132,
0.01990523561835289,
-0.06677339971065521,
-0.010502963326871395,
0.04118308424949646,
0.00715281767770648,
0.016482271254062653,
0.004233984742313623,
0.012771598063409328,
-0.0076619358733296394,
0.033661890774965286,
-0.012529117055237293,
-0.01185342762619257,
-0.0023588931653648615,
0.03877008333802223,
-0.01045433059334755,
0.02494793012738228,
0.006676983088254929,
0.019017944112420082,
0.02446434274315834,
0.026738308370113373,
-0.0034111510030925274,
0.010124044492840767,
-0.01692514680325985,
0.009484045207500458,
0.018090249970555305,
0.025958284735679626,
0.015517028048634529,
-0.053137071430683136,
-0.02425890974700451,
0.0004509913851507008,
-0.0038909236900508404,
-0.023505672812461853,
-0.02986043319106102,
0.03523389995098114,
0.0015359515091404319,
0.014495700597763062,
-0.01510300301015377,
0.00447720754891634,
0.0265166237950325,
0.009020684286952019,
0.01629781164228916,
0.013180075213313103,
-0.034293461591005325,
0.02223038300871849,
0.0025632819160819054,
0.011623460799455643,
0.014532209374010563,
0.0004813848063349724,
0.02130187302827835,
0.012607812881469727,
0.004714390728622675,
0.005557430908083916,
0.0069333952851593494,
0.017434652894735336,
0.012627230025827885,
-0.017741015180945396,
-0.01461867243051529,
-0.03243011236190796,
0.0026102119591087103,
0.020503023639321327,
0.005528673529624939,
0.01702345907688141,
-0.04446883872151375,
0.008686371147632599,
0.014896349050104618,
0.0006836273241788149,
-0.0116391871124506,
-0.0030104429461061954,
0.003879560623317957,
-0.009131062775850296,
-0.007321572862565517,
-0.004009091295301914,
-0.02315002679824829,
0.035101160407066345,
0.010403529740869999,
-0.03311923146247864,
-0.011370554566383362,
0.01190880686044693,
0.00319562666118145,
0.0070242201909422874,
0.00982668437063694,
-0.008512086234986782,
-0.0413779653608799,
0.016189761459827423,
0.028788972645998,
0.024349519982933998,
0.021663207560777664,
0.009152192622423172,
0.01569974422454834,
-0.021074581891298294,
-0.013770162127912045,
0.014712733216583729,
-0.010078459978103638,
-0.012385374866425991,
-0.019777173176407814,
0.009550917893648148,
-0.016565022990107536,
0.002403134945780039,
-0.004015135578811169,
0.007911442779004574,
0.028482040390372276,
0.013522638007998466,
0.01763218268752098,
-0.008914554491639137,
-0.008524554781615734,
0.0063037690706551075,
-0.014406698755919933,
0.013605942949652672,
-0.013533949851989746,
0.015423782169818878,
-0.020878635346889496,
0.00678959209471941,
0.023110434412956238,
0.009930986911058426,
0.005555520299822092,
0.06701616942882538,
-0.01307310163974762,
-0.011472441256046295,
-0.02117326483130455,
-0.006860665511339903,
-0.01840091310441494,
0.006560411769896746,
0.051842618733644485,
-0.02219696342945099,
0.014098986983299255,
-0.016258370131254196,
-0.010839775204658508,
-0.03958331048488617,
-0.020678691565990448,
-0.0139531334862113,
-0.03516506403684616,
0.0049286107532680035,
0.008158023469150066,
0.004326908849179745,
-0.017205283045768738,
0.020548803731799126,
-0.008480620570480824,
-0.00868675671517849,
0.045770905911922455,
0.0011961907148361206,
0.002090168185532093,
0.007193109020590782,
-0.006555730011314154,
-0.001545949256978929,
0.02245435304939747,
-0.002473060507327318,
0.020014656707644463,
0.0009892716770991683,
0.0080695366486907,
-0.007007233798503876,
-0.013036581687629223,
-0.006359125021845102,
0.006044274661689997,
0.019667204469442368,
0.00003856141120195389,
-0.01343489158898592,
-0.008420041762292385,
0.021954091265797615,
-0.010703478008508682,
0.005675278604030609,
0.016584860160946846,
0.03099806047976017,
-0.0026322132907807827,
0.013150724582374096,
0.012324865907430649,
-0.0016982799861580133,
-0.001136216102167964,
-0.013498113490641117,
-0.007368304301053286,
0.00676207197830081,
0.012403007596731186,
0.009269237518310547,
0.011995583772659302,
-0.022075142711400986,
0.010111631825566292,
-0.0123557448387146,
-0.020172683522105217,
-0.0006735525093972683,
0.0027655884623527527,
-0.015316587872803211,
-0.006867470685392618,
-0.0001097444910556078,
-0.013226455077528954,
-0.019998013973236084,
-0.007805125787854195,
-0.006848514545708895,
0.006681243889033794,
0.009391071274876595,
0.02024485357105732,
-0.006601778790354729,
-0.012260734103620052,
-0.01685463637113571,
0.013638121075928211,
-0.007986962795257568,
0.02658763900399208,
0.0015851694624871016,
-0.004969942383468151,
0.004173006862401962,
-0.01053587906062603,
-0.02517663687467575,
0.007970573380589485,
0.022245511412620544,
0.00401662103831768,
0.03896600008010864,
-0.007905078120529652,
0.01063564233481884,
0.004547263495624065,
-0.00626442302018404,
0.0018894677050411701,
-0.08147253841161728,
-0.018928494304418564,
-0.028988607227802277,
-0.006060905288904905,
0.018525108695030212,
-0.031763575971126556,
-0.0060513680800795555,
0.019175900146365166,
-0.010125953704118729,
0.010874265804886818,
0.012650987133383751,
0.03066227398812771,
-0.011861083097755909,
0.007292174268513918,
-0.0150877945125103,
-0.008849192410707474,
0.0070162368938326836,
0.018227268010377884,
-0.012879818677902222,
0.016785548999905586,
-0.006419885437935591,
-0.004082369618117809,
0.009758289903402328,
-0.008563472889363766,
0.003858489915728569,
0.024134241044521332,
0.035218510776758194,
0.0004919301718473434,
-0.023853562772274017,
0.013016055338084698,
0.027116045355796814,
-0.01957351714372635,
0.004642196465283632,
-0.04286039620637894,
-0.007665557321161032,
-0.030224788933992386,
-0.013161713257431984,
0.02001948282122612,
-0.0153255145996809,
-0.009173507802188396,
0.020157387480139732,
0.02501598373055458,
0.022134732455015182,
0.020575467497110367,
0.01370958797633648,
-0.01666642725467682,
0.03500796854496002,
0.01429287251085043,
0.005101151764392853,
0.0013398313894867897,
0.010782837867736816,
-0.0033008947502821684,
0.025587119162082672,
0.00867023691534996,
0.0019220835529267788,
0.002190815284848213,
0.003280394244939089,
-0.0010692626237869263,
-0.0206926167011261,
-0.00786053016781807,
-0.0009600846096873283,
0.0014520238619297743,
0.0022950395941734314,
-0.008411574177443981,
-0.03225632756948471,
-0.009259166195988655,
0.011272409930825233,
0.0005992725491523743,
-0.016199419274926186,
0.008938314393162727,
-0.003996219485998154,
-0.004881361033767462,
0.007568626198917627,
-0.008388304151594639,
-0.009226541966199875,
-0.010789964348077774,
-0.017805609852075577,
-0.0025058239698410034,
-0.01194263156503439,
0.00754211749881506,
-0.015235261991620064,
0.011896790005266666,
-0.021415650844573975,
-0.003316303016617894,
-0.008840944617986679,
-0.015061925165355206,
0.010943908244371414,
-0.011100118979811668,
0.0032775222789496183,
-0.016304578632116318,
0.016672465950250626,
-0.008343922905623913,
-0.027453361079096794,
0.0036308809649199247,
-0.011915107257664204,
-0.005813630297780037,
0.0058853416703641415,
0.021710440516471863,
-0.006484236568212509,
0.012643740512430668,
0.0050004939548671246,
-0.0013699679402634501,
0.02366628125309944,
-0.018158379942178726,
-0.02458776719868183,
0.017450420185923576,
-0.012707207351922989,
-0.023597300052642822,
-0.01111634261906147,
-0.01247179415076971,
-0.012956060469150543,
0.02504124864935875,
-0.007442336529493332,
0.0020663514733314514,
0.008188189938664436,
0.03595750778913498,
0.02016008086502552,
-0.008683083578944206,
0.07146244496107101,
-0.009327135980129242,
0.011014473624527454,
0.00251420633867383,
-0.007723510731011629,
-0.02036714181303978,
0.003044059267267585,
0.005359411705285311,
-0.011275791563093662,
-0.04104158282279968,
0.014573893509805202,
-0.04151390492916107,
-0.01253987941890955,
-0.007262827828526497,
0.0037933234125375748,
-0.024086453020572662,
-0.017559675499796867,
0.01490853913128376,
-0.013422803953289986,
0.007049385458230972,
0.01189340464770794,
0.021172139793634415,
-0.006457319483160973,
0.02563522942364216,
-0.004625908099114895,
-0.012007111683487892,
0.0271038468927145,
-0.010686684399843216,
0.008352763950824738,
0.005839555989950895,
0.01727316528558731,
0.005492290481925011,
-0.0011820411309599876,
-0.029835809022188187,
0.023587696254253387,
-0.031536757946014404,
0.019242577254772186,
0.0063783349469304085,
0.002651318209245801,
0.00033051404170691967,
-0.036830104887485504,
-0.010595123283565044,
0.007079597562551498,
0.02645249292254448,
-0.04021754860877991,
0.018675755709409714,
0.005512756295502186,
-0.005168774165213108,
0.004936814308166504,
0.005045201629400253,
-0.016581572592258453,
0.015601382590830326,
0.01386513002216816,
0.019913243129849434,
-0.0061002084985375404,
0.012576790526509285,
-0.017252519726753235,
0.005961772985756397,
0.005200148560106754,
0.006347996648401022,
-0.044686563313007355,
0.014717631042003632,
0.018357427790760994,
-0.03202361613512039,
0.016056228429079056,
-0.005043520126491785,
0.02267158031463623,
0.00821603648364544,
-0.03368561714887619,
0.029782621189951897,
0.0003471742384135723,
-0.022657565772533417,
0.004654860123991966,
0.0028588888235390186,
-0.013930948451161385,
-0.01450885459780693,
0.00408402644097805,
0.011026585474610329,
0.008801620453596115,
-0.008354210294783115,
-0.009633868932723999,
0.017443064600229263,
-0.0038411044515669346,
-0.007054164540022612,
0.009366746060550213,
0.018808115273714066,
-0.04120619222521782,
-0.07401876151561737,
-0.02094423584640026,
0.007459385320544243,
-0.008860934525728226,
0.002073531039059162,
-0.01433173380792141,
-0.005441585555672646,
-0.004054545424878597,
-0.02985374443233013,
-0.017295148223638535,
-0.04168808460235596,
0.0009412352228537202,
-0.029114609584212303,
0.0017060823738574982,
0.012928327545523643,
0.01733970455825329,
-0.023697176948189735,
-0.012424014508724213,
-0.026483021676540375,
0.007541493978351355,
0.01821092516183853,
0.029895035549998283,
-0.03189497068524361,
-0.002475682646036148,
0.02917143702507019,
-0.08023479580879211,
-0.010700543411076069,
0.02085808478295803,
-0.047989681363105774,
0.014389530755579472,
0.008995008654892445,
-0.0045374128967523575,
-0.033090271055698395,
-0.024885021150112152,
-0.018029477447271347,
-0.04421164095401764,
-0.003522280603647232,
-0.010842110961675644,
-0.0017730515683069825,
-0.02633705362677574,
-0.0047634742222726345,
0.008888772688806057,
0.0036739944480359554,
-0.007938357070088387,
-0.0027584251947700977,
0.014184982515871525,
0.023329302668571472,
-0.011616352014243603,
0.03054499439895153,
-0.014021755196154118,
-0.02184169366955757,
-0.0066998740658164024,
0.004731649532914162,
0.0032038812059909105,
-0.011129328981041908,
0.018111128360033035,
0.028716495260596275,
-0.0017120778793469071,
-0.02199195884168148,
0.021327663213014603,
-0.009230229072272778,
0.002616897923871875,
0.02053152024745941,
0.019096119329333305,
-0.008377746678888798,
-0.009544327855110168,
0.04309879243373871,
-0.019442275166511536,
0.008150856010615826,
-0.00137270987033844,
-0.004432796034961939,
0.0075667849741876125,
0.0009316281648352742,
0.025711368769407272,
-0.002414074493572116,
0.0055267224088311195,
-0.03888359293341637,
0.006104934960603714,
-0.0178083386272192,
0.031587280333042145,
0.004767590202391148,
-0.0083206407725811,
0.01812014728784561,
0.012942522764205933,
0.016930248588323593,
-0.00669405423104763,
-0.009004391729831696,
0.015195423737168312,
0.07157795131206512,
-0.051748935133218765,
0.018495742231607437,
0.015194988809525967,
0.008600442670285702,
-0.005810094065964222,
-0.015365385450422764,
0.0068303439766168594,
-0.019164420664310455,
-0.029021356254816055,
0.00574549799785018,
0.0015059536090120673,
-0.031779345124959946,
0.01652294397354126,
0.026956703513860703,
-0.02933019958436489,
0.012674159370362759,
-0.015311522409319878,
-0.018944624811410904,
-0.004908931907266378,
-0.03168196976184845,
-0.018310019746422768,
-0.019443675875663757,
0.006259399466216564,
0.024628397077322006,
0.0005312053253874183,
-0.0026607865002006292,
-0.004549942445009947,
-0.014234760776162148,
0.0022706342861056328,
-0.00714519526809454,
0.017296910285949707,
0.0013292775256559253,
-0.025914113968610764,
0.03788318485021591,
-0.005415293388068676,
0.031303033232688904,
-0.005048002116382122,
-0.009310249239206314,
0.0032921559177339077,
0.021400751546025276,
-0.007967009209096432,
0.007151136174798012,
-0.021934648975729942,
-0.019716603681445122,
-0.008728886023163795,
-0.0015646398533135653,
0.004283026792109013,
0.016787350177764893,
0.025617901235818863,
0.011360002681612968,
0.0036199442110955715,
-0.006521872244775295,
-0.010394318029284477,
-0.015898017212748528,
-0.020898912101984024,
0.007397050503641367,
0.02182343602180481,
-0.008196387439966202,
-0.044727154076099396,
-0.01737600937485695,
-0.018253415822982788,
-0.021687418222427368,
-0.012142815627157688,
-0.0051050130277872086,
-0.020003527402877808,
0.015775298699736595,
-0.0030010587070137262,
-0.021639686077833176,
0.015417174436151981,
-0.0019365702755749226,
0.0037514991126954556,
0.008030056953430176,
-0.01273537240922451,
0.01251477375626564,
0.0016340991714969277,
0.0330527238547802,
0.018114108592271805,
0.016949091106653214,
0.006874663755297661,
-0.014319952577352524,
-0.02642088197171688,
0.005097119137644768,
0.008610246703028679,
-0.03169842064380646,
0.0114175695925951,
0.0016938373446464539,
-0.019704904407262802,
-0.012896228581666946,
0.00425247848033905,
0.021516481414437294,
-0.004806898068636656,
0.004591705743223429,
0.013588784262537956,
0.005595095921307802,
0.036048464477062225,
-0.012444418855011463,
0.003906023222953081,
0.03540157526731491,
0.008753654547035694,
0.020332371816039085,
-0.024987678974866867,
0.029165156185626984,
0.003944337833672762,
-0.005195777863264084,
-0.00023512262850999832,
0.037501394748687744,
-0.016055434942245483,
-0.000002378597855567932,
-0.0060311066918075085,
-0.0080030532553792,
0.027578862383961678,
-0.007406194694340229,
0.03246191143989563,
-0.0011694207787513733,
0.010288928635418415,
-0.01500729750841856,
-0.003977315034717321,
0.007638703100383282,
-0.008453451097011566,
-0.0020718127489089966,
-0.00915275514125824,
0.008091751486063004,
0.013829891569912434,
-0.00020692404359579086,
0.004617679864168167,
-0.002879259642213583,
-0.023978017270565033,
0.0046606771647930145,
0.00915848184376955,
0.0027416928205639124,
-0.045591168105602264,
-0.011025759391486645,
0.01167930755764246,
-0.01648581027984619,
0.009528450667858124,
0.012912481091916561,
0.003395133651793003,
0.02161456272006035,
-0.05165588855743408,
0.005741371773183346,
-0.008961888961493969,
0.00009462182060815394,
-0.002711685374379158,
0.009089013561606407,
0.026133321225643158,
-0.002550290897488594,
-0.001558714546263218,
0.017864752560853958,
0.01872849464416504,
-0.008381313644349575,
0.002473435364663601,
0.0013739312998950481,
-0.003476921934634447,
-0.009773598052561283,
0.017399106174707413,
0.0009073109831660986,
-0.03148774802684784,
-0.016880150884389877,
0.001054692780598998,
-0.02480497770011425,
0.01219463162124157,
-0.011050829663872719,
0.010245881974697113,
-0.013401907868683338,
-0.014975499361753464,
-0.03731037676334381,
0.03312303125858307,
-0.0032324190251529217,
-0.004061419516801834,
-0.0027375025674700737,
-0.015193456783890724,
0.0013069277629256248,
-0.004128319676965475,
-0.010905520059168339,
-0.020632008090615273,
0.015336946584284306,
0.02826157957315445,
-0.01971890963613987,
0.0022779852151870728,
0.029084578156471252,
-0.02054385095834732,
0.02413932979106903,
-0.009134210646152496,
-0.01828046329319477,
0.0001492598094046116,
-0.006816507782787085,
0.025993939489126205,
0.021647755056619644,
-0.0010020047193393111,
-0.0027989372611045837,
0.006595809943974018,
-0.011191269382834435,
0.002612922340631485,
-0.013398210518062115,
-0.006117084063589573,
-0.015802185982465744,
-0.03582856059074402,
-0.006803455296903849,
0.0018929026555269957,
-0.00026292912662029266,
0.005774366669356823
] | [
0.3282414376735687,
0.10218042135238647,
0.0898246243596077,
0.11113256216049194,
-0.062370751053094864,
0.09275742620229721,
0.25725212693214417,
0.22324924170970917,
-0.3792463541030884,
-1.1462820768356323,
0.22689437866210938,
0.25566521286964417,
-0.6480846405029297,
0.5834136605262756,
0.06185155734419823,
0.2268795222043991,
0.38903334736824036,
0.30388379096984863,
-0.43335190415382385,
0.13499940931797028,
-0.8711044192314148,
-0.04237300157546997,
0.1435628980398178,
0.17210130393505096,
0.19216683506965637,
-0.08661804348230362,
0.29597365856170654,
0.1859259307384491,
0.3576985001564026,
-0.3225588798522949,
0.4604136645793915,
0.45200711488723755,
-0.1287575662136078,
0.0398237369954586,
-0.2074689418077469,
-0.5792233943939209,
-0.3885040581226349,
0.11147774010896683,
-0.288595974445343,
-0.31447654962539673,
-0.37583452463150024,
-0.0017209764337167144,
-0.5142642259597778,
0.04004735127091408,
-0.07880482077598572,
-0.9296370148658752,
-1.3530759811401367,
0.5602889657020569,
-0.16365933418273926,
0.08385445177555084,
-0.08378677070140839,
0.010926634073257446,
0.35009336471557617,
0.37117087841033936,
0.09268820285797119,
0.06812889128923416,
-0.2904229462146759,
0.06530056148767471,
0.11754143238067627,
-0.28006401658058167,
0.13791783154010773,
-0.22662556171417236,
-0.09631236642599106,
-0.035649899393320084,
-0.4034883975982666,
0.4173225164413452,
0.3980545997619629,
-0.05156353861093521,
-0.317163348197937,
-0.4976927638053894,
-0.21218371391296387,
-0.6214029788970947,
0.04446880519390106,
0.17948909103870392,
-0.3938968777656555,
-0.22313617169857025,
-0.023957155644893646,
-0.32340165972709656,
-0.20758329331874847,
0.21762265264987946,
-0.6235591173171997,
0.2491493821144104,
0.12415730953216553,
-0.6855735182762146,
1.0786820650100708,
0.053163010627031326,
0.10627496987581253,
0.8195289969444275,
-0.458475798368454,
0.3457692861557007,
0.16834278404712677,
-0.05970701202750206,
0.5386359691619873,
-0.15544238686561584,
0.5194672346115112,
0.7471650242805481,
0.7979104518890381,
0.1833304613828659,
0.37274205684661865,
0.46052566170692444,
-0.09704070538282394,
-0.10413973033428192,
0.06394006311893463,
-0.3127206861972809,
-0.1445970982313156,
-0.1114257350564003,
-0.20351684093475342,
-0.7356541156768799,
-0.42332735657691956,
0.17308451235294342,
-0.38547787070274353,
-0.06549990177154541,
-0.4667627811431885,
-0.21815700829029083,
-0.3051844537258148,
0.14997752010822296,
0.057696424424648285,
-0.15136773884296417,
0.14079512655735016,
0.024022996425628662,
-0.2938198149204254,
0.8176687359809875,
-0.04172660410404205,
0.5410541892051697,
-0.2344968467950821,
0.21997873485088348,
0.21999762952327728,
-0.15031538903713226,
-0.4054560959339142,
0.1263401061296463,
0.12755733728408813,
0.9459501504898071,
-0.09294754266738892,
-0.23298633098602295,
0.19896827638149261,
-0.3062717914581299,
0.2670970559120178,
0.585962176322937,
0.014332222752273083,
-0.5521347522735596,
-0.2838088274002075,
-0.9862104654312134,
-0.1672685444355011,
0.27817025780677795,
0.12663894891738892,
-0.4309551417827606,
-0.204605370759964,
-0.7602612376213074,
-0.020008636638522148,
-0.4167013168334961,
-0.3409058153629303,
0.211992546916008,
-0.5116026997566223,
0.06186818331480026,
0.09036125242710114,
0.7100347876548767,
0.008152788504958153,
0.06997539848089218,
0.3412606418132782,
0.23386923968791962,
0.11326669901609421,
0.22937259078025818,
-0.36016756296157837,
-0.42833107709884644,
0.16056716442108154,
-0.34590956568717957,
0.16682633757591248,
0.6460179686546326,
0.263473778963089,
0.03545412793755531,
-0.4601418375968933,
-0.10023555159568787,
-0.12985095381736755,
-0.5905762314796448,
0.16124489903450012,
-0.10759370028972626,
0.11491169035434723,
0.10124963521957397,
0.2562843859195709,
0.12177971005439758,
-0.5154849290847778,
-0.14720137417316437,
-0.22423486411571503,
-0.8004077672958374,
0.2116774320602417,
-0.31998372077941895,
0.13538721203804016,
-0.16099858283996582,
-0.13140632212162018,
-0.08546803891658783,
-0.43742236495018005,
-0.03352930769324303,
0.25766482949256897,
-0.7200328707695007,
1.2635018825531006,
-0.4940440356731415,
0.0031059510074555874,
1.482395887374878,
0.33808234333992004,
-0.5188889503479004,
0.052805379033088684,
0.15654556453227997,
0.4113639295101166,
-0.44084474444389343,
-0.8974766731262207,
-0.2997451722621918,
0.15691956877708435,
-0.516511082649231,
-0.13678427040576935,
-0.051396068185567856,
0.5112957954406738,
-0.2268030047416687,
-0.15995876491069794,
-0.7147861123085022,
0.2830105423927307,
0.29678481817245483,
-0.4127788841724396,
0.3545989394187927,
-0.2263173758983612,
0.3815641403198242,
0.5827969908714294,
-0.8756421208381653,
0.5658796429634094,
1.2055609226226807,
0.1319590061903,
0.2288326770067215,
0.8459196090698242,
0.3275206685066223,
1.0853008031845093,
-0.6567797660827637,
0.4091377854347229,
-0.08206091076135635,
0.7002474069595337,
-0.7142348289489746,
-0.34613534808158875,
0.32956060767173767,
0.037462715059518814,
0.047414228320121765,
-0.508705735206604,
-0.22040268778800964,
0.22234930098056793,
0.3327009677886963,
-0.5891242623329163,
0.402264267206192,
0.156779482960701,
-0.39045435190200806,
-0.24228249490261078,
-0.3557792007923126,
-0.39467138051986694,
0.2394997775554657,
0.22313694655895233,
0.7420521378517151,
0.5275994539260864,
-0.8705903887748718,
0.2996446192264557,
-0.12894253432750702,
-0.1078411415219307,
-0.05452478677034378,
0.16192913055419922,
-0.4087839126586914,
-0.06874429434537888,
-0.047748271375894547,
-0.24128271639347076,
0.36735406517982483,
-0.36142992973327637,
-0.6263042092323303,
-0.3933184742927551,
-0.5879972577095032,
0.06354830414056778,
0.6743817329406738,
1.0391250848770142,
-0.19594307243824005,
-0.09495704621076584,
0.08143508434295654,
0.25756511092185974,
-0.6752535104751587,
0.5728504657745361,
0.5898928046226501,
-0.24636004865169525,
-0.21063785254955292,
-0.2569672763347626,
0.016642875969409943,
0.5852352380752563,
-0.7623960971832275,
-0.1629977822303772,
-0.6131801605224609,
0.05058631673455238,
-0.08402252197265625,
-0.5433809161186218,
0.21320129930973053,
-0.6831209659576416,
0.19550009071826935,
-0.04271596670150757,
-0.09216909855604172,
0.3718813359737396,
0.3996741771697998,
-0.26189282536506653,
0.3909345269203186,
0.4927903711795807,
-0.32527902722358704,
-0.06637297570705414,
0.5392451286315918,
-0.07014502584934235,
-0.07651149481534958,
-0.23953869938850403,
-0.18555720150470734,
-0.4994679391384125,
0.5151431560516357,
-5.79520320892334,
-0.35010984539985657,
0.031062865629792213,
-0.1767810434103012,
-0.3416830003261566,
0.03446381911635399,
1.232848882675171,
-0.08378823101520538,
0.3444042503833771,
0.060995038598775864,
0.6485879421234131,
0.5534971356391907,
0.04068347066640854,
-0.003931934013962746,
0.113667793571949,
0.4172466993331909,
0.25895264744758606,
-0.09122651815414429,
0.08825130015611649,
0.05085964500904083,
0.11079580336809158,
0.09319886565208435,
-0.13761109113693237,
0.48986512422561646,
-0.11602818965911865,
-0.5004249811172485,
-0.7535744905471802,
-0.03789369761943817,
-0.1296241283416748,
0.1852540224790573,
-0.19401897490024567,
-0.3276379704475403,
-0.09710507839918137,
-0.07402966916561127,
0.234091117978096,
0.28742605447769165,
-0.130661740899086,
0.09461818635463715,
-0.20596425235271454,
-0.6274245977401733,
0.0691099762916565,
0.45405814051628113,
-0.23208892345428467,
-0.010806294158101082,
0.3038807511329651,
0.06712013483047485,
-0.047447238117456436,
0.22092576324939728,
-0.49195677042007446,
0.9069132208824158,
-0.17617639899253845,
-0.200221985578537,
0.6920965313911438,
0.24162350594997406,
0.27818337082862854,
-0.1907772272825241,
0.10921257734298706,
-0.09766647219657898,
-0.5621641874313354,
0.10265126079320908,
-0.2167791724205017,
-0.27538618445396423,
0.20475329458713531,
-0.32857179641723633,
0.21209882199764252,
0.13821417093276978,
-1.207473874092102,
-0.8602724671363831,
0.24501362442970276,
-0.28436654806137085,
-0.5016242861747742,
0.3953198492527008,
0.1329576075077057,
-0.38185152411460876,
0.1712948977947235,
-0.4231995940208435,
0.3176627457141876,
-0.23831073939800262,
0.5134065747261047,
-0.3338437080383301,
-0.3107477128505707,
0.07075225561857224,
-0.14217376708984375,
-0.17947489023208618,
0.1283198893070221,
-0.09214189648628235,
0.0791841447353363,
-0.3809971213340759,
-0.5667782425880432,
0.1984862983226776,
0.5649474263191223,
-0.1201401799917221,
0.3510131239891052,
0.6910458207130432,
0.4823864698410034,
0.5360785722732544,
0.15994299948215485,
0.3515893816947937,
0.05207686126232147,
-0.7117393612861633,
1.228997826576233,
-0.37661856412887573,
-0.7707861661911011,
-0.9153124094009399,
0.15649592876434326,
0.3526647090911865,
-0.33834823966026306,
0.29258882999420166,
0.575711190700531,
-0.6695523262023926,
0.06299477815628052,
0.25269949436187744,
-0.373050332069397,
-0.3861267566680908,
0.46910330653190613,
-0.2314440906047821,
-0.1374874711036682,
0.42897123098373413,
0.4347721040248871,
0.1191757544875145,
0.24181754887104034,
0.6974030137062073,
-0.09440848231315613,
0.6795176863670349,
0.3921576738357544,
-0.30968108773231506,
-0.05985383316874504,
0.3171516954898834,
-0.1003388836979866,
-0.1810881495475769,
0.5229246020317078,
0.5594756603240967,
-0.1356709897518158,
-0.06683217734098434,
0.3383472263813019,
-0.28008177876472473,
-0.06497927010059357,
-0.1760696917772293,
0.12324102967977524,
-0.31353500485420227,
0.2559777498245239,
-0.023324595764279366,
-0.17732718586921692,
0.031874243170022964,
0.09549562633037567,
0.14870330691337585,
-0.6642157435417175,
0.17765192687511444,
-0.12228463590145111,
-0.17380289733409882,
-0.49146175384521484,
0.03199419006705284,
-0.1340649574995041,
-0.07786783576011658,
-0.4357525706291199,
0.04280173406004906,
0.5747244358062744,
0.022130046039819717,
0.10182910412549973,
-0.35071659088134766,
0.20103423297405243,
0.10291381925344467,
-0.9272470474243164,
0.3153940439224243,
-0.3187350928783417,
0.4326540529727936,
-0.485809862613678,
-0.010937787592411041,
-0.039333440363407135,
0.33509546518325806,
-0.022559622302651405,
-0.4244326651096344,
-0.802422285079956,
-0.2519383132457733,
0.13592936098575592,
-0.13570038974285126,
-0.332265168428421,
0.4709087312221527,
-0.12642024457454681,
0.051206450909376144,
0.1525404006242752,
-0.7971808314323425,
-0.8511793613433838,
0.24078333377838135,
0.32731959223747253,
0.4300939738750458,
0.40977683663368225,
-0.2534784972667694,
-0.1636662781238556,
0.06099650636315346,
0.44465839862823486,
0.36742377281188965,
-0.12433338910341263,
-0.11188093572854996,
0.6542030572891235,
-0.41730615496635437,
0.019694533199071884,
-0.19353149831295013,
-0.03412294760346413,
-0.4613730311393738,
0.5261962413787842,
0.8001517057418823,
-0.9817991852760315,
0.4390518367290497,
0.026559893041849136,
-0.09815096110105515,
-0.12356646358966827,
0.052058544009923935,
0.07776421308517456,
-0.11116936057806015,
-0.5938007235527039,
-0.06481943279504776,
-0.1898009479045868,
0.6829073429107666,
-0.16709382832050323,
0.03560401126742363,
0.030530529096722603,
-0.4642079472541809,
-0.042983103543519974,
0.6194854974746704,
0.17361903190612793,
-0.2610660493373871,
-0.3381544053554535,
-0.11694122850894928,
-0.2468063235282898,
0.608741819858551,
0.43931666016578674,
-0.8243075013160706,
-0.19759711623191833,
0.4359937310218811,
-0.4559573233127594,
-0.0015700932126492262,
0.47119060158729553,
0.04712437838315964,
-0.5946211218833923,
-0.4798943102359772,
-0.058542635291814804,
0.02391873113811016,
0.2519705593585968,
0.060594093054533005,
-0.02091728150844574,
0.6237120032310486,
-0.37250345945358276,
-0.7449446320533752,
0.2778368294239044,
0.34641847014427185,
0.7494957447052002,
-0.4754003882408142,
-0.682116687297821,
-0.17425234615802765,
0.08027531951665878,
-0.5528852939605713,
-0.10973908007144928,
0.0742185190320015,
0.46229317784309387,
0.04381024092435837,
-0.6139676570892334,
-0.10159718990325928,
0.07665799558162689,
-0.051904626190662384,
-0.3773575723171234,
-0.3765294551849365,
-0.4758801758289337,
-0.5126608610153198,
0.6383989453315735,
0.10019701719284058,
-0.16831715404987335,
-0.40928715467453003,
0.044846270233392715,
-0.489154189825058,
0.24120981991291046,
-0.1782122552394867,
0.7459787130355835,
0.5478010773658752,
0.4408499002456665,
0.3173368275165558,
-0.3620198369026184,
0.45620018243789673,
-0.31231847405433655,
-0.1802346110343933,
-0.10851267725229263,
-0.6295955777168274,
0.2701621651649475,
-0.20169436931610107,
0.9179657697677612,
-0.24977697432041168,
0.12428690493106842,
-0.34750309586524963,
0.1326880007982254,
-0.4913371205329895,
-0.18967720866203308,
-0.22014932334423065,
-0.5413331985473633,
0.34429073333740234,
-0.08939561247825623,
0.24451707303524017,
0.2829480469226837,
0.2535010576248169,
0.05213626101613045,
-0.033691078424453735,
-0.21237531304359436,
0.6612033843994141,
0.19491896033287048,
-0.5490434169769287,
0.5507529973983765,
0.07869875431060791,
0.08142577856779099,
0.13961809873580933,
-0.19453227519989014,
0.07619012147188187,
0.2895362675189972,
-0.06884044408798218,
0.2997529208660126,
0.437516450881958,
-0.6423683762550354,
0.020805377513170242,
0.030391816049814224,
-0.40765616297721863,
0.929183304309845,
0.051756586879491806,
-0.06940457224845886,
0.38007161021232605,
0.41343003511428833,
-0.11853764206171036,
0.12714670598506927,
0.8839506506919861,
-0.2005433589220047,
0.06564705818891525,
-0.1541181057691574,
0.14808623492717743,
0.8203548789024353,
0.7880808711051941,
-0.23573951423168182,
-0.07228635996580124,
0.21682724356651306,
0.36869120597839355,
0.1958683878183365,
-0.3048602342605591,
-0.4793189764022827,
0.32588991522789,
0.43632325530052185,
0.050826914608478546,
-0.22739599645137787,
0.20185524225234985,
-0.3284324109554291,
0.6140928864479065,
0.15908436477184296,
0.3764788806438446,
-0.28630200028419495,
0.09061382710933685,
0.39144983887672424,
-0.27273041009902954,
0.06680779159069061,
0.6018476486206055,
-0.24098102748394012,
-0.3374554514884949,
0.5976414680480957,
-0.5442203879356384,
0.12145848572254181,
0.20135338604450226,
0.1908683478832245,
0.3056383430957794,
0.040729690343141556,
0.050644706934690475,
0.10552515834569931,
0.26321789622306824,
0.6308875679969788,
-0.4358786642551422,
0.0017630623187869787,
-0.25646090507507324,
-0.14430296421051025,
0.07015327364206314,
-0.27855634689331055,
0.3962629437446594,
0.1791093945503235,
-0.6243146061897278,
-0.05027803033590317,
0.13287389278411865,
-0.2509347200393677,
0.4168281853199005,
-0.16520927846431732,
0.2998673915863037,
0.2816075384616852,
-0.6018723845481873,
-0.15588755905628204,
0.19448526203632355,
-0.5734941363334656,
0.21799388527870178,
0.10039971768856049,
0.21324987709522247,
0.35318708419799805,
-0.7885838150978088,
-0.10358096659183502,
-0.004253642167896032,
-0.03428441286087036,
0.33994537591934204,
0.18610620498657227,
0.6107185482978821,
0.05776679888367653,
0.19283843040466309,
-0.2601782977581024,
0.3286029100418091,
-0.27702242136001587,
0.443311482667923,
-0.43757933378219604,
0.31099551916122437,
-0.7235947251319885,
-0.37708190083503723,
-0.5475854873657227,
0.3862869441509247,
0.6533600687980652,
0.016875872388482094,
-0.44648101925849915,
-0.09438518434762955,
-0.19965165853500366,
0.6007782816886902,
0.28012776374816895,
-0.3723229467868805,
-0.30626800656318665,
-0.509138822555542,
0.009891904890537262,
-0.5992383360862732,
0.5145273208618164,
-0.11573740839958191,
-0.07344810664653778,
-0.23408356308937073,
0.053000207990407944,
0.6305439472198486,
-0.15116055309772491,
0.6562454700469971,
-0.1914951503276825,
0.1829109489917755,
-0.5757669806480408,
0.2881595492362976,
-0.49402838945388794,
-0.19337749481201172,
-0.16011476516723633,
0.7210952043533325,
0.9039587378501892,
-0.13343383371829987,
0.30014297366142273,
-0.5903663039207458,
0.10949567705392838,
0.33197155594825745,
-0.0032825174275785685,
0.21510283648967743,
0.020746001973748207,
-0.2235635221004486,
-0.5692856907844543,
0.5276074409484863,
0.231634259223938,
-0.4981704652309418,
-0.27564916014671326,
0.033342402428388596,
-0.38338977098464966,
0.3320953845977783,
-0.0003528081870172173,
-0.741252601146698,
0.034534797072410583,
-0.08402115106582642
] |
BACKGROUND: Human CEACAM1 is a cell-cell adhesion molecule with multiple functions including insulin clearance in the liver, vasculogenesis in endothelial cells, lumen formation in the mammary gland, and binding of certain human pathogens. PRINCIPAL FINDINGS: Three genomic BAC clones containing the human CEACAM1 gene were microinjected into pronuclei of fertilized FVB mouse oocytes. The embryos were implanted in the oviducts of pseudopregnant females and allowed to develop to term. DNA from newborn mice was evaluated by PCR for the presence of the human CEACAM1 gene. Feces of the PCR positive offspring screened for expression of human CEACAM1. Using this assay, one out of five PCR positive lines was positive for human CEACAM1 expression and showed stable transmission to the F1 generation with the expected transmission frequency (0.5) for heterozygotes. Liver, lung, intestine, kidney, mammary gland, and prostate were strongly positive for the dual expression of both murine and human CEACAM1 and mimic that seen in human tissue. Peripheral blood and bone marrow granulocytes stained strongly for human CEACAM1 and bound Neisseria Opa proteins similar to that in human neutrophils. CONCLUSION: These transgenic animals may serve as a model for the binding of human pathogens to human CEACAM1. | [
-0.015852611511945724,
0.017796717584133148,
-0.0027940147556364536,
0.01371749211102724,
-0.0018129204399883747,
-0.010892132297158241,
0.007648521102964878,
0.0004261923022568226,
-0.010586243122816086,
0.0068201832473278046,
0.0016920455964282155,
0.0037471591494977474,
0.005601859651505947,
0.01583772525191307,
-0.009222626686096191,
0.02155674621462822,
-0.021500201895833015,
-0.004215172491967678,
0.014151498675346375,
-0.006518272683024406,
0.03033243864774704,
-0.028453899547457695,
0.007222029380500317,
-0.007616464979946613,
0.023565908893942833,
0.011176402680575848,
0.01236893329769373,
-0.0002130032517015934,
0.007550821173936129,
-0.012819265946745872,
0.005903673358261585,
-0.016641130670905113,
-0.0013618648517876863,
0.0038795587606728077,
-0.006629932206124067,
-0.01255169790238142,
-0.004259710665792227,
0.014363782480359077,
0.02148478478193283,
-0.004734154790639877,
0.015412148088216782,
-0.010451452806591988,
0.015127734281122684,
0.0023149659391492605,
-0.008618848398327827,
-0.01907302811741829,
0.00010121549712494016,
0.0036418484523892403,
0.01649797521531582,
0.0028662506956607103,
-0.007470935583114624,
-0.0011993162333965302,
-0.004826217889785767,
0.0096856988966465,
-0.0041189612820744514,
-0.029487207531929016,
0.013663559220731258,
-0.00996167492121458,
-0.0048951017670333385,
-0.003400432411581278,
0.02106255292892456,
-0.0051732370629906654,
0.02008095756173134,
0.001211928203701973,
-0.008575940504670143,
-0.06756015121936798,
-0.00025300681591033936,
0.008196554146707058,
-0.0034153626766055822,
0.003256046213209629,
0.01976233907043934,
0.004701253958046436,
-0.003474891884252429,
0.014421570114791393,
0.014513631351292133,
-0.03366123139858246,
0.008893433026969433,
-0.004367724526673555,
0.014045201241970062,
0.023970041424036026,
0.015822049230337143,
-0.021613772958517075,
0.014974348247051239,
0.006540591828525066,
0.009940591640770435,
0.004423860460519791,
-0.018678389489650726,
0.006593635305762291,
0.018520724028348923,
-0.010496548376977444,
0.007503769360482693,
-0.004778084345161915,
0.0063168383203446865,
-0.0024644462391734123,
-0.011426092125475407,
0.011176198720932007,
0.0027751242741942406,
-0.014112917706370354,
-0.0059789312072098255,
0.012734368443489075,
-0.020927289500832558,
-0.013386096805334091,
0.011387687176465988,
-0.00310336472466588,
-0.018439937382936478,
0.008345641195774078,
-0.002372883027419448,
-0.012555332854390144,
0.009855000302195549,
0.009731221944093704,
-0.009502233006060123,
-0.012524737976491451,
-0.005826323758810759,
0.008573539555072784,
0.0055634379386901855,
-0.02126380056142807,
0.013742358423769474,
-0.022794706746935844,
0.015199877321720123,
-0.0064595420844852924,
-0.002823839895427227,
0.011099614202976227,
0.010087124072015285,
0.0055555016733706,
0.0007683438016101718,
-0.0006345668807625771,
0.006789731793105602,
0.004994948394596577,
0.001157777151092887,
-0.0032756184227764606,
-0.0066546788439154625,
0.012910464778542519,
-0.021222487092018127,
0.007115695625543594,
-0.023564636707305908,
0.001638262066990137,
-0.0028860922902822495,
-0.0035760109312832355,
-0.006284718401730061,
-0.016013458371162415,
0.0031334171071648598,
0.005884058773517609,
0.009255724027752876,
0.010194036178290844,
0.006322591565549374,
0.0024493555538356304,
-0.006738472729921341,
0.002278353087604046,
0.01721901074051857,
-0.0006534542189911008,
-0.0025962982326745987,
-0.012865830212831497,
-0.015872381627559662,
-0.00949875358492136,
-0.018608035519719124,
-0.000688476487994194,
-0.002393303904682398,
-0.009320943616330624,
0.009132856503129005,
0.015984680503606796,
0.000025875051505863667,
-0.0072545441798865795,
0.006087831687182188,
0.007137537933886051,
0.030804192647337914,
0.013079062104225159,
-0.01776288077235222,
-0.0029543652199208736,
-0.002070871414616704,
0.006266598589718342,
-0.002963717095553875,
-0.0010489586275070906,
-0.019623950123786926,
0.00423029949888587,
-0.011236123740673065,
0.0038929360453039408,
0.012921304441988468,
0.0060235606506466866,
-0.01924419403076172,
0.0669289231300354,
-0.015613273717463017,
0.011828205548226833,
-0.012106058187782764,
0.03379999101161957,
0.012207141146063805,
-0.027085931971669197,
0.009378721937537193,
-0.013200638815760612,
-0.011274266056716442,
-0.023613348603248596,
-0.013467051088809967,
-0.016983216628432274,
-0.015081143006682396,
0.02045876532793045,
-0.00788109377026558,
0.0024527686182409525,
-0.00007446459494531155,
0.020221957936882973,
0.0025818843860179186,
0.013116146437823772,
-0.013017995283007622,
0.00036164652556180954,
-0.013255561701953411,
0.0027724478859454393,
0.003644179552793503,
0.004290674813091755,
-0.0034688394516706467,
0.019991425797343254,
-0.007007915992289782,
-0.010944511741399765,
-0.004300141241401434,
-0.007460199762135744,
-0.0024647796526551247,
-0.005055953748524189,
0.010858307592570782,
0.003976103849709034,
0.00037935248110443354,
0.012909743934869766,
0.0014806757681071758,
-0.00788232870399952,
-0.008438892662525177,
-0.0040627457201480865,
0.00979685876518488,
0.04128561541438103,
0.012120136991143227,
-0.00928301177918911,
0.009114152751863003,
0.010779442265629768,
0.016285959631204605,
0.01552953477948904,
-0.03316611051559448,
-0.013010513968765736,
-0.011644517071545124,
-0.03284147381782532,
-0.007562451064586639,
-0.010268612764775753,
0.012401266023516655,
-0.01758342981338501,
0.0033995320554822683,
-0.004511130973696709,
-0.0110273826867342,
0.0002595039550215006,
-0.006799129769206047,
0.0002016681246459484,
0.0014866776764392853,
0.0040340605191886425,
-0.005936588626354933,
-0.005964252632111311,
-0.008404532447457314,
-0.010913627222180367,
0.007850205525755882,
-0.018332744017243385,
0.03001714125275612,
-0.011512232013046741,
0.016732443124055862,
-0.002928201574832201,
-0.0006342466222122312,
-0.007355983834713697,
0.021325167268514633,
0.0005730146076530218,
-0.005831071175634861,
0.008053562603890896,
0.0039499010890722275,
0.010563299059867859,
0.022992480546236038,
0.017884811386466026,
0.01063801720738411,
0.05259859934449196,
0.035179782658815384,
-0.015263556502759457,
0.009528503753244877,
-0.00806351751089096,
0.001134101185016334,
-0.08196650445461273,
-0.006018000654876232,
-0.015701325610280037,
0.0056334687396883965,
0.003508114255964756,
0.0462341234087944,
0.011906658299267292,
-0.0145725067704916,
0.004312445409595966,
-0.010298311710357666,
0.01754053309559822,
0.004178052302449942,
-0.012371320277452469,
-0.01808956451714039,
-0.002173381857573986,
-0.0006713243201375008,
0.007902471348643303,
-0.02882111817598343,
-0.002395184710621834,
-0.0013512317091226578,
0.009036624804139137,
0.0107565987855196,
-0.004674264695495367,
-0.017087996006011963,
-0.011369623243808746,
0.0069941384717822075,
-0.016601592302322388,
-0.0003440800355747342,
0.02044399082660675,
0.0021152449771761894,
-0.004299800377339125,
-0.011806721799075603,
0.006318084429949522,
0.025196120142936707,
-0.0021337512880563736,
0.0008707661181688309,
-0.016165833920240402,
0.006954018492251635,
-0.01020144671201706,
0.006278013810515404,
-0.03236671909689903,
0.01614171639084816,
0.0064376648515462875,
0.016139661893248558,
0.0031423717737197876,
-0.013659399002790451,
-0.003683933289721608,
-0.003247051266953349,
0.023346908390522003,
-0.012475169263780117,
0.000711509957909584,
0.001165671506896615,
0.03978298604488373,
0.021363552659749985,
-0.010361941531300545,
-0.018196066841483116,
0.0050435722805559635,
0.006921068765223026,
-0.006006530020385981,
0.0010620426619425416,
0.007256315089762211,
0.0026975232176482677,
-0.011878828518092632,
0.0077529060654342175,
-0.0012154905125498772,
0.023638995364308357,
0.01326054334640503,
-0.012232343666255474,
0.0014361562207341194,
0.01743553765118122,
0.0033197300508618355,
-0.0033221114426851273,
0.020043333992362022,
-0.007060539443045855,
0.011433240957558155,
-0.007896455004811287,
-0.008878957480192184,
-0.003201043698936701,
0.0062300413846969604,
-0.02518681436777115,
-0.006385113578289747,
-0.005415227729827166,
-0.006659570150077343,
-0.011186795309185982,
-0.01082332618534565,
-0.026593558490276337,
0.005981199909001589,
0.023135699331760406,
0.004504590295255184,
-0.007159866858273745,
0.015136204659938812,
0.013863286934792995,
0.005079004913568497,
0.009098207578063011,
-0.01816219463944435,
0.011416156776249409,
0.00003247632412239909,
0.017994895577430725,
0.02618132159113884,
0.004955772776156664,
-0.0011373227462172508,
-0.004231875296682119,
0.011323638260364532,
-0.011011475697159767,
-0.03360123187303543,
0.012184647843241692,
0.007621515076607466,
0.007160430774092674,
-0.01906151883304119,
-0.0027926648035645485,
-0.0065665775910019875,
-0.028281420469284058,
-0.008836290799081326,
-0.026608850806951523,
0.006821407936513424,
0.03847390413284302,
-0.014245511963963509,
-0.0008308151736855507,
0.07295185327529907,
-0.012332143262028694,
-0.011574165895581245,
-0.01647987589240074,
0.022695954889059067,
-0.011945024132728577,
0.010786682367324829,
0.00009587593376636505,
0.0003586364910006523,
0.020404746755957603,
0.009110815823078156,
-0.036657147109508514,
-0.0029145225416868925,
0.004362740553915501,
-0.014657304622232914,
0.01795300841331482,
-0.011835871264338493,
-0.02605978585779667,
0.013628534972667694,
-0.00503905164077878,
0.005563823506236076,
0.00687405513599515,
0.006118916906416416,
0.0034256784711033106,
-0.011306609958410263,
-0.029187435284256935,
0.009861760772764683,
-0.012918266467750072,
-0.0220648106187582,
0.006618567742407322,
0.0384712740778923,
0.006329795345664024,
-0.007508678827434778,
0.013218794018030167,
0.019908154383301735,
-0.028970027342438698,
0.025988800451159477,
-0.004894028417766094,
-0.0020027479622513056,
-0.005322090815752745,
0.0025057632010430098,
-0.011935979127883911,
-0.001954751554876566,
0.006670111790299416,
0.002263127826154232,
-0.011984073556959629,
0.01916632428765297,
-0.009724312461912632,
0.009862422943115234,
-0.02291001006960869,
-0.004884303081780672,
-0.007730056066066027,
0.014057740569114685,
0.005556422285735607,
0.006873587612062693,
0.019393904134631157,
0.01726527325809002,
0.001985633745789528,
0.0000015823752619326115,
-0.010975394397974014,
-0.030413253232836723,
0.002663704100996256,
0.036733243614435196,
-0.01244066096842289,
0.006232905201613903,
-0.0043862867169082165,
0.0018978193402290344,
0.007238768041133881,
-0.0029908812139183283,
-0.01687142625451088,
0.00675631919875741,
-0.0007630521431565285,
-0.005541346967220306,
-0.018395496532320976,
-0.02536473423242569,
-0.007510199211537838,
0.028102900832891464,
-0.009186438284814358,
-0.015117867849767208,
0.0317220501601696,
0.003508304711431265,
-0.018683236092329025,
0.0004802430048584938,
-0.019796131178736687,
-0.00235436437651515,
0.003061540424823761,
0.0041425516828894615,
-0.07511065900325775,
-0.0005519450642168522,
0.004808520898222923,
-0.0004691368667408824,
0.02636144310235977,
-0.01912125200033188,
-0.013803518377244473,
0.008855361491441727,
-0.016398495063185692,
0.0020308149978518486,
0.0007573980838060379,
-0.011292072013020515,
0.01733734831213951,
0.002307616174221039,
0.012349499389529228,
0.004666783846914768,
-0.00525555107742548,
0.0009662174852564931,
-0.0023202048614621162,
-0.021241242066025734,
-0.008333360776305199,
-0.014180597849190235,
-0.013556553050875664,
0.0068730819039046764,
-0.015008874237537384,
-0.08176177740097046,
0.015456034801900387,
0.011195280589163303,
-0.006742357276380062,
-0.005104543641209602,
-0.0008201871532946825,
0.001887794118374586,
-0.009920553304255009,
-0.0056200893595814705,
-0.010754216462373734,
-0.0006056713173165917,
0.007285383529961109,
-0.003626981284469366,
-0.0037468834780156612,
0.00012809177860617638,
-0.00571089144796133,
0.007608314510434866,
0.021057628095149994,
-0.002523824106901884,
0.034965936094522476,
0.0008115191012620926,
0.00696894945576787,
-0.008054429665207863,
-0.001987569034099579,
-0.00998988188803196,
-0.015097511932253838,
-0.025912996381521225,
0.014813560992479324,
-0.01021604798734188,
0.010742833837866783,
-0.01835078001022339,
-0.014628566801548004,
-0.01735461875796318,
-0.014840979129076004,
-0.008844045922160149,
-0.01674240082502365,
-0.006104078609496355,
-0.0073530361987650394,
0.010546967387199402,
0.00015476159751415253,
-0.0006029876531101763,
-0.029101967811584473,
0.01159592904150486,
0.018237384036183357,
0.024683386087417603,
-0.006636297795921564,
0.0055854348465800285,
-0.003185942070558667,
0.007887610234320164,
0.03992903232574463,
0.010763028636574745,
0.01437867246568203,
-0.003669554367661476,
-0.0032119527459144592,
0.009605682455003262,
-0.005211802665144205,
0.004830308258533478,
0.0012782770209014416,
0.01172932330518961,
0.0004567960277199745,
-0.004633021075278521,
0.011406917124986649,
-0.004126320593059063,
0.07221201807260513,
-0.010826418176293373,
0.013286124914884567,
0.018199779093265533,
-0.0076619768515229225,
0.007044085301458836,
0.005651435349136591,
0.02542206645011902,
0.002076687291264534,
-0.015461284667253494,
0.01723017916083336,
0.003527852240949869,
0.0036550061777234077,
0.008875115774571896,
0.0010051552671939135,
0.0009869958739727736,
0.018550172448158264,
-0.031106697395443916,
-0.007750493474304676,
0.0032223996240645647,
-0.018649881705641747,
0.0027261669747531414,
-0.009916333481669426,
0.01607850193977356,
0.01062487717717886,
-0.0013520935317501426,
-0.01812952384352684,
0.006854811683297157,
0.009709328413009644,
-0.004837710410356522,
-0.00041462667286396027,
0.010344164445996284,
-0.0018237100448459387,
-0.01849355548620224,
0.008637409657239914,
0.010632498189806938,
-0.007000689394772053,
0.011339914053678513,
-0.02488476224243641,
-0.026924364268779755,
0.019533582031726837,
-0.011512809433043003,
-0.005307401530444622,
-0.0011675831628963351,
0.007815242744982243,
0.00012197531759738922,
0.011473676189780235,
0.01765967346727848,
0.008443712256848812,
0.00866696797311306,
0.017515107989311218,
0.004423628561198711,
-0.015547441318631172,
0.007983259856700897,
0.019450895488262177,
0.017710484564304352,
-0.01602068729698658,
0.012309292331337929,
-0.004038531333208084,
-0.029157111421227455,
0.019205233082175255,
-0.015561113134026527,
-0.022937890142202377,
-0.012880517169833183,
0.03178896754980087,
0.0022131167352199554,
0.03167130798101425,
-0.009217295795679092,
-0.005516058765351772,
0.012664109468460083,
-0.02046937867999077,
0.00420353002846241,
0.0068670231848955154,
0.016070302575826645,
0.012108981609344482,
0.008493027649819851,
-0.0039029940962791443,
-0.0007706279866397381,
0.012181496247649193,
0.011708520352840424,
-0.00787840411067009,
0.030808858573436737,
0.006456377450376749,
0.015634989365935326,
-0.03284256160259247,
0.003299931064248085,
0.004297052044421434,
0.00820714421570301,
0.006088906433433294,
0.005408902652561665,
0.016821905970573425,
-0.012784980237483978,
0.012294820509850979,
0.016574330627918243,
0.010148871690034866,
0.0322858989238739,
0.004061264451593161,
-0.0004798769950866699,
0.013143947347998619,
0.016292134299874306,
0.009427735581994057,
0.00852307491004467,
-0.028663765639066696,
-0.0341171957552433,
-0.01789170876145363,
-0.0076255216263234615,
-0.01141190342605114,
-0.010708948597311974,
0.01477418839931488,
0.04111017286777496,
-0.019235733896493912,
0.01790323108434677,
0.027825089171528816,
0.003004108788445592,
-0.0020800726488232613,
0.011278157122433186,
-0.019858498126268387,
0.010026149451732635,
0.002277959603816271,
-0.013213630765676498,
-0.012479840777814388,
-0.01229308731853962,
-0.020685769617557526,
-0.0011168851051479578,
-0.03720003366470337,
-0.035560570657253265,
-0.005696131847798824,
0.018680542707443237,
-0.015981361269950867,
-0.02298641949892044,
0.013054408133029938,
0.002795351203531027,
0.0053306035697460175,
0.014498447999358177,
0.010474858805537224,
0.005715506616979837,
-0.019017159938812256,
-0.009230868890881538,
-0.015503439120948315,
0.007713341619819403,
-0.009279272519052029,
-0.021387264132499695,
-0.001232856884598732,
0.015018448233604431,
0.006369673181325197,
0.007780282758176327,
-0.008613855578005314,
-0.022628070786595345,
0.005010654218494892,
0.01363039668649435,
0.006832382641732693,
0.013646446168422699,
-0.002265424933284521,
-0.0067966775968670845,
-0.0011583870509639382,
0.01785346493124962,
0.010081259533762932,
-0.017526114359498024,
-0.007117845118045807,
-0.004892812110483646,
-0.0007573829498142004,
0.015926383435726166,
-0.0037298579700291157,
-0.00855775736272335,
0.04169253259897232,
0.003870912129059434,
-0.01715359464287758,
-0.005765632726252079,
0.016807686537504196,
-0.0004254719242453575,
0.022622333839535713,
0.01845364272594452,
-0.019159389659762383,
0.004914388991892338,
-0.0241183340549469,
-0.015413635410368443,
-0.00003061193274334073,
0.003645403543487191,
0.004563905298709869,
-0.00025681755505502224,
-0.010046776384115219,
-0.007735484279692173,
0.012096494436264038,
-0.005125091411173344,
-0.00872121099382639,
0.017926696687936783,
-0.011148754507303238,
-0.015158784575760365,
0.005730635020881891,
-0.01230064406991005,
-0.0054063037969172,
-0.026952195912599564,
-0.004796627443283796,
-0.0002188635990023613,
-0.018788551911711693,
-0.00031276140362024307,
0.011292715556919575,
0.005441530607640743,
0.00566317280754447,
-0.007435240782797337,
0.020448578521609306,
0.0025634029880166054
] | [
0.34390631318092346,
0.2031451314687729,
0.0010491552529856563,
-0.028148118406534195,
0.43285247683525085,
0.20275132358074188,
-0.007161746267229319,
0.04120585322380066,
0.1985650509595871,
-0.4449975788593292,
0.30888664722442627,
0.07066117227077484,
-0.1499435305595398,
-0.029928768053650856,
-0.41516029834747314,
0.32416048645973206,
0.36430424451828003,
0.7120863199234009,
0.03463710471987724,
-0.4480760991573334,
-0.12246803194284439,
-0.3678056299686432,
0.1336802840232849,
-0.012395362369716167,
0.23090973496437073,
0.1824406534433365,
0.355279803276062,
0.10759960860013962,
0.675022304058075,
-0.2090565711259842,
-0.2135867327451706,
0.31985893845558167,
0.16273142397403717,
-0.45246073603630066,
-0.11433860659599304,
-0.04358180984854698,
-0.3524555563926697,
0.1502859741449356,
0.0942382887005806,
-0.21994549036026,
-0.6373596787452698,
-0.10344341397285461,
-0.10316160321235657,
0.3289000391960144,
-0.29895955324172974,
-0.27854910492897034,
-1.4139410257339478,
0.5031761527061462,
-0.3675483167171478,
0.04310363903641701,
0.18552495539188385,
0.055534977465867996,
0.30161574482917786,
-0.1561950147151947,
0.3644961714744568,
-0.009263511747121811,
-0.7657610177993774,
-0.39342182874679565,
0.17946495115756989,
-0.5510863065719604,
-0.04261022433638573,
0.020696304738521576,
0.11586898565292358,
0.10184495151042938,
-0.4006882309913635,
0.589286208152771,
0.21134726703166962,
-0.4282085597515106,
0.10349145531654358,
-0.2705343961715698,
-0.055738020688295364,
-0.28417834639549255,
-0.3152843713760376,
0.3018907308578491,
0.005186461843550205,
-0.25766170024871826,
-0.3186229169368744,
-0.1886487901210785,
0.396603524684906,
0.1282966434955597,
0.07911470532417297,
0.040724556893110275,
0.43957632780075073,
-0.010677306912839413,
0.3311645984649658,
0.3522460460662842,
0.04622535780072212,
0.4262514114379883,
-0.8496350049972534,
0.25630220770835876,
-0.5981844067573547,
-0.1953197419643402,
0.35302063822746277,
0.5069541335105896,
-0.035595670342445374,
0.2878527343273163,
-0.23315808176994324,
0.036192893981933594,
0.16917648911476135,
0.30509132146835327,
-0.43809571862220764,
0.2743935286998749,
-0.3715301752090454,
-0.2878223955631256,
-0.4966766834259033,
-0.005490974523127079,
-0.2803769111633301,
-0.5341566205024719,
-0.7590054869651794,
-0.1570824533700943,
-0.38941308856010437,
-0.25344690680503845,
-0.6221973896026611,
0.05110679194331169,
0.09594634175300598,
0.4543198049068451,
-0.0006039828876964748,
-0.16274121403694153,
-0.10230027139186859,
-0.03505735099315643,
-0.3721036911010742,
1.1849474906921387,
-0.25893816351890564,
0.04308249056339264,
0.1167430579662323,
0.03082945942878723,
-0.02905609831213951,
-0.12690278887748718,
0.04972245171666145,
0.7435629963874817,
0.099546879529953,
0.4031048119068146,
-0.23678655922412872,
0.27588948607444763,
-0.0016713845543563366,
0.21123218536376953,
0.407173216342926,
0.3360663950443268,
0.13737770915031433,
0.3781903088092804,
-0.35134509205818176,
-0.0893394872546196,
-0.16507910192012787,
0.09722861647605896,
-0.0849648267030716,
-0.4952036142349243,
-0.09414537250995636,
0.3668286204338074,
-0.3623235821723938,
0.30254408717155457,
0.1093406155705452,
-0.37040290236473083,
-0.4182218909263611,
-0.2052990198135376,
-0.035579126328229904,
0.36853456497192383,
-0.21680030226707458,
0.0008177119889296591,
-0.2678799033164978,
0.47039031982421875,
0.37529420852661133,
0.42311328649520874,
-0.40209728479385376,
0.04594152048230171,
0.2857655882835388,
0.285127192735672,
0.5442025661468506,
0.3361865282058716,
-0.07504118978977203,
0.29320666193962097,
0.053872138261795044,
-0.5047284960746765,
-0.035400163382291794,
-0.6606811285018921,
-0.4419792592525482,
0.15941596031188965,
0.49772414565086365,
-0.35126855969429016,
-0.1309647560119629,
0.23658594489097595,
-0.5943560004234314,
0.06412860006093979,
-0.5196741223335266,
-0.20239192247390747,
0.16902349889278412,
-0.17991703748703003,
0.3218323588371277,
0.04553050920367241,
-0.19411799311637878,
-0.18065650761127472,
-0.0903647169470787,
-0.20777614414691925,
0.9236971139907837,
-0.4616624116897583,
1.4412564039230347,
-0.4626099765300751,
-0.3257533013820648,
0.9919517040252686,
0.0043850368820130825,
0.01769866794347763,
-0.08928215503692627,
0.030019180849194527,
0.614457368850708,
-0.5879442095756531,
-0.2531295716762543,
-0.10307321697473526,
-0.3016469180583954,
-0.28337034583091736,
0.2913489043712616,
0.291543573141098,
0.22990575432777405,
0.21359854936599731,
0.12090934067964554,
-0.07267263531684875,
0.4074229598045349,
-0.3323149085044861,
0.30715125799179077,
-0.09465231001377106,
-0.214039146900177,
0.00003613394437707029,
0.39097005128860474,
-0.37798982858657837,
0.41416484117507935,
0.6465696096420288,
-0.1259220838546753,
0.5032397508621216,
0.669294536113739,
0.045291319489479065,
0.8006817102432251,
-0.3067759573459625,
0.3313813805580139,
-0.03535675257444382,
0.21501244604587555,
-0.48975375294685364,
-0.15606997907161713,
0.14604552090168,
-0.038306478410959244,
-0.020728999748826027,
0.08287988603115082,
0.2798858880996704,
-0.06228006258606911,
0.7108376026153564,
-0.5473199486732483,
-0.3460588753223419,
0.02475110813975334,
-0.7741444706916809,
-0.03547123074531555,
0.4236253798007965,
-1.1549233198165894,
-0.28130704164505005,
-0.5333387851715088,
0.11119772493839264,
0.038954149931669235,
-0.20709887146949768,
0.08170090615749359,
-0.1298767328262329,
-0.471561461687088,
-0.6021203994750977,
0.11146865040063858,
-0.18684586882591248,
0.23727981746196747,
-0.10625310987234116,
0.6185367703437805,
0.5018345713615417,
0.4354541599750519,
-0.15557585656642914,
-0.48876410722732544,
-0.4684077203273773,
0.8474992513656616,
0.6066760420799255,
1.0480828285217285,
-0.28613534569740295,
-0.4262722134590149,
-0.17277225852012634,
0.37950342893600464,
-0.2316892445087433,
-0.19489926099777222,
0.5839748382568359,
-0.05944615975022316,
-0.3233029544353485,
0.0005766726681031287,
0.0013632932677865028,
0.3810226619243622,
-0.026826895773410797,
-0.135698601603508,
-0.13799062371253967,
-0.42166486382484436,
-0.4595552384853363,
-0.49912625551223755,
-0.11387114971876144,
-0.034786026924848557,
0.3187420070171356,
-0.35267019271850586,
-0.10316534340381622,
0.45278236269950867,
0.1827138364315033,
0.16582730412483215,
0.3133338689804077,
0.6059326529502869,
0.069046251475811,
-0.02420995570719242,
0.5924462676048279,
-0.3039206266403198,
0.022284546867012978,
0.10864638537168503,
0.23701971769332886,
0.0900905430316925,
-0.1833837777376175,
-6.032746315002441,
0.3682112395763397,
0.09952376037836075,
-0.33815136551856995,
0.1729978322982788,
-0.17410241067409515,
0.9928567409515381,
0.03770965337753296,
0.17091098427772522,
0.1324654519557953,
0.42391276359558105,
0.3390484154224396,
-0.28094834089279175,
-0.07408783584833145,
-0.1496182680130005,
-0.15765561163425446,
-0.4673052430152893,
-0.2818230092525482,
0.6507445573806763,
0.19581280648708344,
-0.13016818463802338,
-0.5549229979515076,
0.011035049334168434,
0.3934263586997986,
-0.029412878677248955,
-0.41094261407852173,
-1.1897543668746948,
0.27940553426742554,
-0.46245864033699036,
-0.05746942386031151,
0.3147871196269989,
-0.4410439431667328,
-0.15739180147647858,
-0.4982132911682129,
0.1434503048658371,
0.20221902430057526,
-0.012485750019550323,
-0.0682523250579834,
-0.03624805808067322,
-0.2410799264907837,
0.5023849606513977,
0.15876400470733643,
-0.09267707914113998,
-0.012926745228469372,
0.11211081594228745,
0.00586985656991601,
-0.13085900247097015,
0.16963313519954681,
-0.4218418598175049,
0.6754555106163025,
-0.14258833229541779,
0.010217125527560711,
-0.11633288860321045,
0.4790308177471161,
0.6053513884544373,
0.156675323843956,
-0.1652500182390213,
0.044415432959795,
-0.7332490682601929,
0.19072389602661133,
-0.4047701060771942,
-0.32532867789268494,
-0.09784039109945297,
-0.9164901375770569,
0.400748074054718,
0.08776991069316864,
-0.6326083540916443,
0.23053087294101715,
0.46680596470832825,
-0.3544783890247345,
0.2649937868118286,
-0.10036272555589676,
-0.22458256781101227,
-0.945138692855835,
0.3341260254383087,
-0.5024996995925903,
0.12496921420097351,
0.16212138533592224,
-0.26530325412750244,
0.16456259787082672,
0.07556303590536118,
0.16325071454048157,
0.12407577782869339,
-0.03864865005016327,
0.2368174046278,
-0.11569934338331223,
-0.14564768970012665,
-0.1268501728773117,
-0.2556883990764618,
0.5386897325515747,
0.4523530900478363,
-0.11489748954772949,
-0.3402702510356903,
0.4126773774623871,
-0.10237177461385727,
-0.04770444706082344,
-0.15781792998313904,
0.6072162389755249,
0.33428657054901123,
-0.25962498784065247,
0.7184008359909058,
0.009429940953850746,
-0.5160883069038391,
-0.7055757641792297,
-0.07770572602748871,
-0.04676956310868263,
-0.85466468334198,
0.0374828577041626,
0.4679722189903259,
-0.9590657949447632,
0.011147873476147652,
-0.1643369346857071,
-0.27971842885017395,
-0.12486346065998077,
0.5859270095825195,
-0.14462879300117493,
-0.0723007470369339,
0.2899635136127472,
0.8845415711402893,
-0.32445064187049866,
0.13421224057674408,
0.32462647557258606,
-0.5984676480293274,
0.20964118838310242,
0.1949118822813034,
-0.4125138819217682,
0.48286232352256775,
0.6195877194404602,
-0.6731026768684387,
-0.1591462343931198,
-0.006093809846788645,
0.22685162723064423,
-0.6913141012191772,
-0.12180223315954208,
0.3874882459640503,
-0.11583128571510315,
-0.8001554012298584,
0.20825718343257904,
0.4122890532016754,
0.1840371936559677,
0.3239709436893463,
-0.19047127664089203,
0.42136287689208984,
0.1864054948091507,
0.3964512348175049,
0.08919352293014526,
-0.08375124633312225,
0.22654911875724792,
-0.4708326458930969,
-0.24474415183067322,
0.6235076785087585,
0.10745461285114288,
0.13603468239307404,
0.03497606888413429,
-0.4619992971420288,
0.3662741184234619,
0.5461716651916504,
0.200576514005661,
0.05892690271139145,
-0.3082851469516754,
0.547810435295105,
0.23162990808486938,
-0.6526899337768555,
0.20387820899486542,
-0.047539979219436646,
-0.7743536233901978,
0.05357159674167633,
-0.4661351442337036,
-0.15441979467868805,
0.031694445759058,
-0.1282210350036621,
-0.5363002419471741,
0.15916746854782104,
-0.039578668773174286,
-0.04022768512368202,
-0.04691239446401596,
-0.35766884684562683,
0.06856777518987656,
-0.10804809629917145,
0.08496543020009995,
0.1656302809715271,
-0.4222949147224426,
-0.1924360692501068,
0.12886637449264526,
0.868465781211853,
0.4253336191177368,
-0.08414923399686813,
-0.3486328125,
-0.1199718490242958,
-0.5419376492500305,
0.17811846733093262,
0.1101619303226471,
0.6637772917747498,
-0.20966987311840057,
0.0006764623103663325,
0.23803934454917908,
0.032787445932626724,
0.6269911527633667,
0.039588697254657745,
-0.40438494086265564,
-0.16197428107261658,
0.14504434168338776,
-0.4865097105503082,
0.6188406944274902,
0.40176573395729065,
-0.12982992827892303,
-0.16624173521995544,
0.12335196882486343,
-0.1601240485906601,
-0.2746981978416443,
-0.2668202221393585,
-0.9619119763374329,
-0.09454658627510071,
0.39021626114845276,
-0.16812948882579803,
0.10446181148290634,
0.09264563769102097,
-0.19460663199424744,
-0.10532845556735992,
0.22349674999713898,
0.4744921326637268,
0.0508020855486393,
-0.1674288809299469,
-0.15176509320735931,
-0.41361406445503235,
0.14323025941848755,
0.2973909080028534,
-0.711807370185852,
0.3263064920902252,
0.10308867692947388,
-0.10309106856584549,
-0.06202302873134613,
0.02680969052016735,
-0.08376701921224594,
-0.7123241424560547,
-0.3875059485435486,
-0.18340003490447998,
-0.14369358122348785,
0.007211548741906881,
0.5793127417564392,
0.2445695996284485,
0.2303941547870636,
-0.3464551866054535,
-0.1508074700832367,
0.03308979421854019,
0.8324215412139893,
-0.13419859111309052,
-0.36019760370254517,
-0.05637796223163605,
0.44983816146850586,
-0.017413051798939705,
-0.15091510117053986,
0.41836243867874146,
0.5420567393302917,
0.782910168170929,
0.04371955618262291,
-0.12916548550128937,
-0.1910398155450821,
-0.3445700407028198,
-0.10357457399368286,
-0.3013474941253662,
-0.1322789490222931,
-0.07211818546056747,
0.028520887717604637,
0.03313734754920006,
-0.18041013181209564,
-0.18753837049007416,
-0.19705861806869507,
0.516241192817688,
0.10067463666200638,
-0.00796916987746954,
-0.2838418483734131,
0.660658597946167,
0.5581203699111938,
-0.3526277244091034,
0.20572252571582794,
-0.22978100180625916,
0.12064556032419205,
-0.21671262383460999,
0.31040555238723755,
-0.14502756297588348,
-0.4452311098575592,
0.48234379291534424,
-0.10895982384681702,
0.32119637727737427,
-0.6732214689254761,
-0.3209805488586426,
-0.43300941586494446,
0.3865315318107605,
-0.234894797205925,
-0.30594828724861145,
0.3615882098674774,
-0.4923933744430542,
-0.7063183188438416,
0.02613714337348938,
0.4613451659679413,
0.3018755316734314,
0.13789451122283936,
0.11780621856451035,
-0.007693851366639137,
-0.35962674021720886,
0.6362985968589783,
0.8241997361183167,
-0.23379747569561005,
-0.27379971742630005,
0.27039727568626404,
-0.08399365842342377,
0.06612980365753174,
-0.6074311137199402,
-0.15495339035987854,
-0.026382729411125183,
-0.16361238062381744,
0.29846101999282837,
-0.5089777112007141,
-0.6351690888404846,
-0.09061094373464584,
-0.4810199439525604,
-0.40842124819755554,
-0.043099623173475266,
0.18714798986911774,
0.25764501094818115,
0.712329626083374,
0.47557711601257324,
-0.44974392652511597,
0.11500340700149536,
0.4153817892074585,
0.4983457624912262,
0.3985244929790497,
-0.47124120593070984,
0.4187503159046173,
0.5565384030342102,
0.17640134692192078,
0.11348672211170197,
0.6579546332359314,
0.6889952421188354,
0.4106253683567047,
0.23009014129638672,
-0.41734060645103455,
-0.14990143477916718,
-0.1507551372051239,
0.3455730378627777,
0.482549786567688,
-0.18659257888793945,
-0.19298292696475983,
0.36024126410484314,
-0.06898065656423569,
0.030059894546866417,
0.3627149164676666,
0.2140955924987793,
0.7010093927383423,
0.009583340026438236,
-0.6727406978607178,
-0.4695795476436615,
0.3410221338272095,
-0.49015676975250244,
0.2599365711212158,
0.2751825153827667,
-0.29026317596435547,
-1.1444854736328125,
0.2604615390300751,
-0.7525270581245422,
-0.049364734441041946,
0.35331496596336365,
0.8042975068092346,
0.08578116446733475,
0.003709920682013035,
0.26695194840431213,
0.4548148810863495,
0.5694565773010254,
0.013220868073403835,
0.026924360543489456,
-0.05733618885278702,
-0.23567378520965576,
0.23472629487514496,
0.4390261471271515,
-0.40066981315612793,
-0.02150207944214344,
-0.44330301880836487,
-0.2107420265674591,
0.25679337978363037,
-0.5349009037017822,
0.03959110006690025,
-0.17622849345207214,
-0.28268882632255554,
-0.5702428817749023,
0.06367316097021103,
-0.18807274103164673,
-0.007827331312000751,
-0.056896429508924484,
-0.0902937650680542,
0.09804479032754898,
-0.6269947290420532,
0.7746761441230774,
-0.13521315157413483,
0.18579809367656708,
0.3694456219673157,
0.1119714006781578,
-0.0957767441868782,
0.5556399822235107,
0.21282647550106049,
-0.1892290860414505,
0.29515179991722107,
-0.20345912873744965,
0.06762895733118057,
-0.29655027389526367,
0.777870237827301,
-0.5336209535598755,
-0.3081008195877075,
-0.42381051182746887,
-0.2969987094402313,
0.9606910943984985,
0.536237895488739,
-0.2049088180065155,
0.13912835717201233,
0.28158387541770935,
0.4807766377925873,
0.32278966903686523,
-0.3310536742210388,
-0.3372078835964203,
-0.4934602677822113,
-0.17669996619224548,
-0.5851821899414062,
0.5530667304992676,
0.08441359549760818,
-0.14488624036312103,
-0.009158489294350147,
0.6424033641815186,
0.3787270486354828,
-0.25886914134025574,
0.33265572786331177,
-0.33263713121414185,
0.031191540881991386,
-0.2738611400127411,
0.3077240586280823,
-0.5954927802085876,
-0.14671893417835236,
-0.20140579342842102,
0.6370859146118164,
0.11404735594987869,
0.019799580797553062,
0.14723806083202362,
-0.10120318084955215,
0.10517188906669617,
-0.004603442270308733,
0.11627845466136932,
-0.09480823576450348,
-0.09168974310159683,
-0.7099848985671997,
-0.8417275547981262,
-0.3831896483898163,
-0.11789865046739578,
-0.7168638110160828,
-0.14252358675003052,
-0.11330348253250122,
-0.18109723925590515,
0.060700125992298126,
-0.002114870585501194,
-0.1883038431406021,
-0.2523132264614105,
-0.10434358566999435
] |
[
0.030699975788593292,
0.10140369832515717,
-0.04192632809281349,
0.06293141841888428,
-0.03267847001552582,
-0.12038351595401764,
0.035765983164310455,
-0.05915536358952522,
-0.008488839492201805,
-0.05911063775420189,
-0.05657084658741951,
-0.005575065966695547,
-0.05070307105779648,
0.06654473394155502,
-0.05232572928071022,
-0.10524960607290268,
-0.11025319993495941,
0.10980250686407089,
0.11460278183221817,
-0.11366231739521027,
-0.0736834928393364,
-0.014200853183865547,
0.03315950185060501,
-0.042415086179971695,
-0.18886972963809967,
0.04834016412496567,
-0.010257190093398094,
-0.013155662454664707,
-0.11621294915676117,
0.22128282487392426,
0.026432644575834274,
-0.0035340951289981604,
0.09944672882556915,
0.0506606251001358,
0.07618589699268341,
-0.1337132453918457,
-0.07806193083524704,
0.018981769680976868,
-0.056862808763980865,
-0.14643901586532593,
-0.16388945281505585,
-0.057634275406599045,
0.07937344908714294,
-0.0544847771525383,
-0.024052107706665993,
-0.07310523092746735,
-0.07155387103557587,
-0.10090649873018265,
-0.028452187776565552,
0.14460046589374542,
-0.05908972769975662,
-0.0028850892558693886,
-0.030829090625047684,
-0.06325825303792953,
-0.02312028780579567,
-0.15990810096263885,
-0.09092682600021362,
-0.016466086730360985,
0.06645786762237549,
0.04531364515423775,
-0.11512433737516403,
0.10278821736574173,
-0.23874814808368683,
-0.08993463963270187,
0.04214683547616005,
-0.06208702549338341,
0.19159553945064545,
0.06058281660079956,
0.04147198423743248,
0.04145164415240288,
0.08241380751132965,
0.07910601049661636,
-0.21460114419460297,
-0.04764945060014725,
-0.06004532054066658,
-0.05771621689200401,
0.04311008378863335,
0.029352186247706413,
-0.007787349633872509,
0.0667465552687645,
0.11730451881885529,
-0.036040034145116806,
0.0379948653280735,
0.08618149906396866,
0.09119251370429993,
-0.12663358449935913,
-0.027850864455103874,
-0.026794370263814926,
0.10444615036249161,
-0.19966867566108704,
-0.06711355596780777,
0.020024478435516357,
0.02054487355053425,
-0.07212473452091217,
-0.12159039080142975,
-0.23648804426193237,
-0.04011392965912819,
0.10453135520219803,
-0.08162038028240204,
-0.047898195683956146,
-0.14109919965267181,
-0.09871640801429749,
0.006453124340623617,
0.08454540371894836,
-0.20008768141269684,
0.031001994386315346,
0.3166082501411438,
-0.08357764780521393,
-0.06154737249016762,
0.05468873679637909,
-0.10438451170921326,
-0.043026577681303024,
0.039880186319351196,
-0.002967559266835451,
0.04125188663601875,
0.10730873048305511,
-0.031131744384765625,
0.07599066942930222,
0.11015765368938446,
0.2026078850030899,
0.0340835340321064,
-0.11498764902353287,
0.00341621832922101,
0.1823115050792694,
0.08721653372049332,
0.08886470645666122,
0.038886621594429016,
-0.14626866579055786,
-0.10826382040977478,
-0.10755138099193573,
-0.043079130351543427,
0.06791600584983826,
-0.08626728504896164,
-0.13008858263492584,
-0.06684456765651703,
-0.0757908821105957,
-0.12930254638195038,
0.10704216361045837,
-0.16803321242332458,
0.12600107491016388,
-0.04051733389496803,
0.056915540248155594,
0.09876076132059097,
0.05756385996937752,
0.12005363404750824,
-0.09532523900270462,
-0.0735682025551796,
0.04351639747619629,
0.12305520474910736,
-0.12239664793014526,
-0.03981996327638626,
-0.02161284163594246,
-0.10828825831413269,
-0.0646689310669899,
-0.03846750035881996,
0.19904725253582,
-0.03407208248972893,
-0.10436071455478668,
0.018596051260828972,
0.10414863377809525,
0.09536723792552948,
-0.014020226895809174,
0.04361536353826523,
0.028888408094644547,
-0.06593406200408936,
0.008343683555722237,
0.04160940647125244,
-0.011753213591873646,
-0.11578797549009323,
0.05167029798030853,
-0.06676144897937775,
0.1441592276096344,
-0.22843779623508453,
0.12496988475322723,
0.028016896918416023,
-0.05906530097126961,
0.17457708716392517,
0.05070481076836586,
-0.11385047435760498,
0.060045935213565826,
-0.09621882438659668,
0.05438654124736786,
0.03432608023285866,
0.15427951514720917,
0.11706224828958511,
-0.002386678010225296,
0.00803310889750719,
-0.07359828799962997,
0.15835100412368774,
0.017626335844397545,
-0.007624693680554628,
-0.04966338351368904,
-0.04089459404349327,
0.07255762070417404,
0.21151596307754517,
0.06603258103132248,
0.09396278113126755,
-0.018833069130778313,
0.02596215531229973,
0.07787297666072845,
0.0033172147814184427,
-0.03406890109181404,
-0.0378173291683197,
0.0016285512829199433,
0.17468418180942535,
0.14436595141887665,
0.07670074701309204,
-0.018170222640037537,
-0.12715241312980652,
0.011177051812410355,
0.04855913668870926,
0.05172306299209595,
-0.04483100771903992,
-0.031188545748591423,
0.21232262253761292,
-0.12014889717102051,
0.04454215243458748,
-0.006694146431982517,
-0.008590037934482098,
0.010534912347793579,
-0.005982778966426849,
-0.049038566648960114,
-0.03788432478904724,
-0.148992121219635,
-0.15680280327796936,
0.11952607333660126,
-0.03443474322557449,
-0.009466748684644699,
-0.17385894060134888,
0.06695250421762466,
-0.08063670247793198,
0.1111515536904335,
-0.05964672192931175,
-0.08919277042150497,
0.07400178909301758,
-0.08179539442062378,
0.010917145758867264,
-0.10002771019935608,
0.030084840953350067,
-0.05879339575767517,
0.15256229043006897,
-0.0588756687939167,
0.058464743196964264,
-0.06250129640102386,
-0.1272299885749817,
0.14816193282604218,
0.11261296272277832,
-0.20878300070762634,
0.07267408818006516,
-0.19025585055351257,
0.04558248072862625,
-0.06399069726467133,
0.09287825971841812,
-0.14967121183872223,
0.0832153856754303,
0.0884755551815033,
-0.07130222767591476,
-0.08636317402124405,
-0.062446922063827515,
-0.0917036235332489,
0.04213356599211693,
0.02685438096523285,
-0.07510712742805481,
0.14564858376979828,
-0.1311965137720108,
0.06008942797780037,
0.10980391502380371,
0.23106127977371216,
0.06301818042993546,
-0.11306808888912201,
0.4958252012729645,
-0.08599810302257538,
-0.10827255249023438,
-0.07431084662675858,
0.00557404151186347,
-0.010929758660495281,
0.19725823402404785,
0.07282532006502151,
0.12956568598747253,
0.12012496590614319,
-0.32143303751945496,
-0.003951505292207003,
0.031411223113536835,
0.2858768403530121,
0.007240592502057552,
-0.04573579132556915,
-0.15110504627227783,
-0.06919705122709274,
-0.05780123919248581,
0.045537661761045456,
0.08062059432268143,
0.05595998466014862,
-0.19111478328704834,
0.20023339986801147,
0.030304836109280586,
0.16707292199134827,
-0.019236214458942413,
0.14964352548122406,
-0.0109718581661582,
0.08966008573770523,
-0.1306983232498169,
-0.10273553431034088,
0.05057602375745773,
-0.10228367894887924,
-0.014037727378308773,
0.01175781711935997,
-0.19365377724170685,
0.07810384780168533,
-0.09055490046739578,
-0.024642886593937874,
-0.007601541467010975,
0.024362703785300255,
0.1254616379737854,
-0.048288214951753616,
0.038688793778419495,
-0.023422805592417717,
-0.039048850536346436,
0.09871713072061539,
-0.12935157120227814,
-0.08097562938928604,
-0.08026036620140076,
0.09477176517248154,
-0.016387617215514183,
0.016990656033158302,
-0.08228129148483276,
-0.013419480063021183,
0.09099746495485306,
-0.12665517628192902,
-0.11556627601385117,
-0.06357208639383316,
0.13796506822109222,
-0.03748014569282532,
-0.06792362779378891,
-0.11707259714603424,
-0.03880562260746956,
0.021529851481318474,
0.1335168182849884,
-0.20159269869327545,
-0.020768262445926666,
0.03235907480120659,
0.17776764929294586,
-0.13711069524288177,
0.054383035749197006,
0.1364498734474182,
-0.0664997398853302,
-0.13668900728225708,
-0.05714643374085426,
0.06318619847297668,
-0.04915833845734596,
-0.037615757435560226,
-0.030773334205150604,
0.16446112096309662,
-0.04886315017938614,
-0.18910305202007294,
0.07617077976465225,
-0.016795340925455093,
0.09917127341032028,
-0.018028702586889267,
0.17936013638973236,
0.1950056403875351,
-0.07366102188825607,
0.06003068387508392,
-0.06908491253852844,
0.010838094167411327,
-0.01070399209856987,
-0.02660319395363331,
0.013416670262813568,
-0.06685419380664825,
-0.02624829299747944,
-0.03683823347091675,
-0.09697310626506805,
-0.18608561158180237,
0.0381377749145031,
0.14146940410137177,
-0.1311713010072708,
0.07777606695890427,
-0.01577705889940262,
-0.17565688490867615,
0.03242841362953186,
0.033038247376680374,
-0.10881786793470383,
-0.11456996947526932,
-0.020494369789958,
0.029386846348643303,
0.09281162917613983,
0.1401824951171875,
0.15178707242012024,
0.040599074214696884,
0.09011775255203247,
-0.24185405671596527,
-0.048800211399793625,
0.0538560152053833,
0.024362187832593918,
0.08835064619779587,
-0.12078657001256943,
-0.029829923063516617,
-0.050800859928131104,
-0.027568737044930458,
0.11569537967443466,
-0.08833982795476913,
-0.07752125710248947,
0.04416066035628319,
0.10488185286521912,
-0.03403449431061745,
-0.036388035863637924,
-0.028469476848840714,
0.00013972366286907345,
-0.02620040997862816,
0.019505295902490616,
0.03172631934285164,
-0.009704504162073135,
-0.008721652440726757,
0.02358195185661316,
-0.02107628993690014,
0.10953398793935776,
-0.12684720754623413,
-0.011352095752954483,
0.20320820808410645,
0.11569026112556458,
0.06384299695491791,
0.07973365485668182,
0.07756686955690384,
-0.014700566418468952,
-0.07601739466190338,
-0.15688274800777435,
0.043123140931129456,
-0.07327551394701004,
0.11937576532363892,
-0.16742980480194092,
-0.06767740845680237,
-0.032997481524944305,
0.03229013830423355,
-0.07201521098613739,
0.020497772842645645,
0.1007266715168953,
0.10656307637691498,
-0.006670929957181215,
0.045204728841781616,
-0.11228744685649872,
0.03726661205291748,
-0.09642747044563293,
-0.021383125334978104,
0.09304244816303253,
0.16754911839962006,
0.046043168753385544,
-0.06674063950777054,
0.05671413242816925,
-0.1691814512014389,
-0.09079419821500778,
0.02362711913883686,
-0.03823481500148773,
0.032727308571338654,
0.027651354670524597,
-0.06272287666797638,
0.25346511602401733,
-0.0711563304066658,
-0.09735190868377686,
0.09871630370616913,
-0.09277880936861038,
0.17078223824501038,
-0.04301628842949867,
-0.12943820655345917,
0.09328215569257736,
-0.03212863951921463,
0.07257618755102158,
-0.0919959545135498,
-0.09690722078084946,
-0.014983730390667915,
-0.02383156679570675,
0.1599690020084381,
0.2708745300769806,
0.004232767503708601,
0.06919010728597641,
-0.18598918616771698,
-0.18889376521110535,
0.12317569553852081,
0.20423759520053864,
-0.018112223595380783,
0.05860372632741928,
0.04035134240984917,
0.23361057043075562,
-0.036147184669971466,
0.09624502807855606,
0.15925373136997223,
-0.05318930000066757,
0.0999671220779419,
-0.1810319870710373,
-0.05631474032998085,
0.24686497449874878,
-0.29344862699508667,
-0.08175241202116013,
-0.1502540409564972,
0.03189156949520111,
-0.21783162653446198,
-0.0316685251891613,
0.0770697370171547,
0.011430091224610806,
-0.20418010652065277,
0.12323997914791107,
-0.05420595780014992,
-0.06644335389137268,
0.017708318307995796,
-0.031245650723576546,
-0.069255530834198,
0.029646968469023705,
-0.010673110373318195,
-0.043574053794145584,
0.04528564214706421,
-0.010181069374084473,
0.17210781574249268,
-0.11144612729549408,
-0.03275112062692642,
-0.01416890136897564,
-0.11918938905000687,
0.16780740022659302,
-0.04347151517868042,
-0.07990653067827225,
-0.1383093297481537,
-0.07701651751995087,
0.13612787425518036,
0.06718118488788605,
-0.03026001900434494,
-0.10584010183811188,
0.1504666954278946,
0.04537953436374664,
-0.04277321323752403,
-0.07999415695667267,
-0.05302651226520538,
0.06232829764485359,
-0.06967832148075104,
0.006939463783055544,
0.03764990344643593,
-0.16889509558677673,
-0.0128104779869318,
-0.12893931567668915,
0.004090023227035999,
-0.10927903652191162,
0.02363210916519165,
-0.0021094942931085825,
0.09061166644096375,
-0.15584534406661987,
0.10387682914733887,
-0.05615909397602081,
-0.08126594126224518,
-0.12864066660404205,
-0.10040390491485596,
0.049997348338365555,
-0.06948837637901306,
-0.2262738049030304,
0.07372745871543884,
-0.0751219317317009,
-0.023589715361595154,
0.0006566792726516724,
0.015917714685201645,
0.015185697935521603,
0.1439286172389984,
-0.048737782984972,
0.04775804653763771,
-0.03251831233501434,
-0.08096536993980408,
0.11022157967090607,
0.08137879520654678,
0.06090184673666954,
-0.00013641569239553064,
-0.08019585907459259,
0.029292188584804535,
0.0633009821176529,
-0.12884356081485748,
0.08761142194271088,
0.026820791885256767,
-0.08458266407251358,
0.07295160740613937,
0.15415427088737488,
-0.0795522928237915,
0.11442394554615021,
0.02001115493476391,
0.09106463938951492,
-0.016615290194749832,
-0.21292705833911896,
0.10298934578895569,
0.05502275377511978,
0.0073677487671375275,
-0.2833021283149719,
0.02874218113720417,
-0.11885728687047958,
0.14102113246917725,
0.07653405517339706,
0.09427811205387115,
-0.18969523906707764,
0.029876410961151123,
0.09227520227432251,
-0.013809707947075367,
-0.19043710827827454,
0.2721906006336212,
-0.09463087469339371,
0.16874489188194275,
-0.0929885283112526,
-0.20977464318275452,
0.11410222947597504,
-0.24532605707645416,
0.1033991351723671,
-0.10767566412687302,
0.1346479207277298,
0.04692460969090462,
-0.06546223908662796,
-0.06456930190324783,
-0.016968602314591408,
-0.17973142862319946,
0.006486006546765566,
0.12100864946842194,
0.16770276427268982,
0.09269894659519196,
-0.02782367542386055,
0.08303628861904144,
-0.01005392987281084,
0.12554210424423218,
-0.0039508226327598095,
0.06577645242214203,
-0.16509583592414856,
0.04058369994163513,
-0.1464710533618927,
0.06944134086370468,
0.004074519500136375,
0.030400428920984268,
-0.23784418404102325,
-0.16445674002170563,
0.17691773176193237,
-0.04592552036046982,
-0.12712617218494415,
-0.0823761522769928,
0.09494348615407944,
0.1738746613264084,
0.09308170527219772,
-0.06952536106109619,
-0.018745578825473785,
0.057547252625226974,
0.07872483134269714,
0.09157146513462067,
0.04403744265437126,
0.016956856474280357,
-0.09269630163908005,
-0.029361916705965996,
-0.06743098795413971,
-0.28720706701278687,
0.07613074034452438,
0.005947081837803125,
-0.04800977557897568,
0.05805841088294983,
-0.22678130865097046,
0.00736323744058609,
-0.036018453538417816,
-0.09721697121858597,
0.21445755660533905,
0.14375033974647522,
-0.037552669644355774,
0.07481253147125244,
0.047465730458498,
0.12795665860176086,
0.0499894879758358,
0.3371717631816864,
0.1206621453166008,
0.04664211347699165,
0.07534867525100708,
0.11638755351305008,
-0.1137082502245903,
-0.01809467002749443,
0.027630813419818878,
-0.07026474177837372,
0.10068340599536896,
-0.033441174775362015,
-0.02745586819946766,
-0.09059090167284012,
-0.016674429178237915,
-0.09251946210861206,
-0.1066908910870552,
-0.14217059314250946,
-0.0029501612298190594,
-0.10616209357976913,
-0.12213589251041412,
0.23970355093479156,
-0.06059916317462921,
0.09325772523880005,
-0.027130169793963432,
0.08298519998788834,
-0.11706145107746124,
-0.025369465351104736,
0.02586756832897663,
-0.10644304752349854,
0.07422038167715073,
0.011267676949501038,
0.040812499821186066,
0.11823710054159164,
-0.12311052531003952,
0.036918528378009796,
-0.09282504767179489,
-0.07867162674665451,
0.09925122559070587,
0.00831183698028326,
0.07572954893112183,
0.18012267351150513,
-0.11015387624502182,
0.25394564867019653,
0.0647750273346901,
-0.010540131479501724,
-0.14140892028808594,
0.09216330945491791,
0.14021435379981995,
-0.07399103045463562,
0.030010830610990524,
-0.0632258877158165,
0.026569640263915062,
-0.31273141503334045,
0.09507186710834503,
0.048706747591495514,
0.03564697876572609,
0.0877167135477066,
0.044927213340997696,
0.0967792421579361,
-0.12211425602436066,
-0.1670200675725937,
0.09019871801137924,
0.036771178245544434,
-0.01080002449452877,
0.07695483416318893,
0.17063258588314056,
0.04803616926074028,
-0.10535462200641632,
0.06133848801255226,
0.10331029444932938,
-0.0652971938252449,
0.12990865111351013,
0.06802456825971603,
0.031069843098521233,
-0.06295310705900192,
-0.0010956355836242437,
-0.042811691761016846,
0.05890437588095665,
-0.03734767809510231,
-0.0005172397359274328,
0.023220261558890343,
-0.13965068757534027,
-0.07897917926311493,
-0.0788731500506401,
0.023132644593715668,
0.04229813814163208,
0.0890314057469368,
-0.07917604595422745,
-0.03219835087656975,
0.1405557245016098,
-0.03651417791843414,
-0.04889789968729019,
0.03253275156021118,
-0.08247864246368408,
-0.03458242863416672,
-0.04264979436993599,
-0.04301273822784424,
-0.09590031951665878,
0.13572357594966888,
0.0012255808105692267,
0.16827429831027985,
0.0843420997262001,
-0.09352738410234451,
0.03125839680433273,
-0.28809845447540283,
0.08971253037452698,
-0.049394357949495316,
0.11219234764575958,
-0.16251173615455627
] | [
-0.6405137181282043,
-0.40237531065940857,
-0.4379032552242279,
0.4858168959617615,
0.026843443512916565,
0.8250871896743774,
0.591051459312439,
0.49869590997695923,
-0.05352409556508064,
-0.5380819439888,
-0.030063176527619362,
0.1934276521205902,
-0.17665459215641022,
-0.2884982228279114,
0.21587994694709778,
0.6314683556556702,
0.07805005460977554,
0.01826055534183979,
0.7228599190711975,
-0.17166107892990112,
0.09680569171905518,
-0.02651747688651085,
0.3800112009048462,
0.005414656829088926,
-0.27775484323501587,
-0.3200223743915558,
-0.5080534815788269,
-0.2075829803943634,
-0.3583580255508423,
0.2830114960670471,
-0.5827750563621521,
0.12257585674524307,
0.436928391456604,
0.3532000184059143,
0.564717710018158,
0.048827674239873886,
-0.07594364136457443,
-0.12622830271720886,
0.053892455995082855,
0.07402795553207397,
-0.5602610111236572,
0.11546620726585388,
0.21992602944374084,
0.2670930027961731,
0.18983040750026703,
-0.04674329236149788,
-1.2200636863708496,
0.3175443112850189,
-0.17276346683502197,
-0.8183501362800598,
-0.5250676274299622,
-0.19748036563396454,
0.3238544166088104,
0.5963900089263916,
0.11509183794260025,
-0.107943594455719,
0.35183751583099365,
0.2924298644065857,
-0.15422554314136505,
0.19241882860660553,
0.8530176877975464,
0.5063220262527466,
0.34927883744239807,
0.2658578157424927,
-0.23652294278144836,
0.05941621586680412,
0.42366692423820496,
0.050829172134399414,
-0.19484123587608337,
-0.711532711982727,
0.17822271585464478,
0.7535077333450317,
0.14014923572540283,
0.10093405097723007,
-0.3228948712348938,
0.20055116713047028,
-0.19007807970046997,
0.28901323676109314,
0.10063039511442184,
-0.03848069906234741,
-0.1955675482749939,
-0.8078544735908508,
0.04586132615804672,
-0.11808034032583237,
-0.24477964639663696,
-0.40330132842063904,
0.8196008801460266,
-0.13639597594738007,
-0.9123497605323792,
0.4288228750228882,
-0.7800590991973877,
0.031614482402801514,
0.29552367329597473,
0.5088914632797241,
0.5439472794532776,
-0.18054720759391785,
-0.21971161663532257,
-0.05083504319190979,
0.6170822978019714,
-0.712860107421875,
-0.5503864288330078,
-0.9498862028121948,
-0.5838750004768372,
-0.03559653460979462,
-0.6456656455993652,
0.021811138838529587,
-1.0994744300842285,
0.11977823823690414,
-0.3225787580013275,
0.3308296799659729,
-0.7427442669868469,
-0.19227683544158936,
0.3549487292766571,
0.19111023843288422,
-0.39548635482788086,
-0.023019053041934967,
-0.0343155562877655,
-0.17994794249534607,
-0.1811835765838623,
-0.1845594048500061,
-0.005594165064394474,
0.1260816603899002,
-0.17074158787727356,
0.2197311520576477,
-0.20783691108226776,
0.035901594907045364,
-0.366798460483551,
0.30805057287216187,
-0.12659867107868195,
0.17417366802692413,
-0.03723131865262985,
-0.23911958932876587,
-0.2008027583360672,
0.026582183316349983,
-0.21551357209682465,
-0.5486097931861877,
-0.21325384080410004,
0.052347972989082336,
-0.03783343732357025,
0.07125475257635117,
-0.13377344608306885,
0.008458757773041725,
0.27349352836608887,
-0.34788942337036133,
0.39084601402282715,
-0.6821686029434204,
-0.6143672466278076,
0.24633195996284485,
-0.7538977265357971,
0.05913751944899559,
0.25489965081214905,
0.35555312037467957,
-0.1638355553150177,
0.3167976140975952,
0.3675808012485504,
0.3050578832626343,
0.007362578995525837,
-0.15388232469558716,
-0.3047502338886261,
-0.0821155235171318,
0.35859501361846924,
0.6810493469238281,
0.2259669452905655,
-0.08428235352039337,
0.7316536903381348,
-0.22368060052394867,
-0.6080368161201477,
0.48941099643707275,
-0.19647999107837677,
0.2771236002445221,
-0.5139791965484619,
-0.662840723991394,
0.27492234110832214,
-0.1847514808177948,
-0.250088095664978,
0.48996007442474365,
0.2121702879667282,
0.3231496810913086,
0.4580309987068176,
-0.3447554409503937,
-0.23925529420375824,
0.034911416471004486,
-0.20812639594078064,
0.06909839808940887,
0.10304594039916992,
-0.3709271252155304,
0.7266157865524292,
-0.01675555296242237,
0.24747776985168457,
-0.05028047785162926,
-0.44722867012023926,
0.11035291850566864,
0.42860254645347595,
0.007925187237560749,
0.03177899494767189,
-0.14207139611244202,
0.025058120489120483,
-0.006179651711136103,
-0.5869449973106384,
-0.5620450377464294,
-0.08105451613664627,
-0.01896088942885399,
0.08508529514074326,
-0.06164143607020378,
-0.6453149318695068,
0.2898566424846649,
-0.19194786250591278,
-0.8347829580307007,
-0.17305921018123627,
0.16413678228855133,
-0.01736634038388729,
0.29173094034194946,
-0.31920695304870605,
0.2484014332294464,
0.03193426504731178,
-0.05750153586268425,
-0.5523152947425842,
-0.37817129492759705,
-0.031182529404759407,
0.010498217307031155,
0.6141337156295776,
0.005562508013099432,
0.5754885673522949,
0.09742695093154907,
0.24905730783939362,
0.595888614654541,
0.3569446802139282,
-0.04178495332598686,
0.2616642415523529,
-0.33417198061943054,
-0.44338324666023254,
-0.18796509504318237,
-0.07724089920520782,
0.09030621498823166,
-0.18053226172924042,
-0.038269173353910446,
0.2791324555873871,
-0.3814674913883209,
0.440965473651886,
-0.4539218246936798,
-0.437311589717865,
0.27674201130867004,
-0.39244967699050903,
0.32035577297210693,
-0.34466156363487244,
0.2573222815990448,
0.030993448570370674,
0.2983739972114563,
-0.009839211590588093,
-0.38673514127731323,
0.11693607270717621,
-0.066309355199337,
-0.4121782183647156,
-0.1592489331960678,
0.7279937863349915,
-0.3668922781944275,
-0.6626343131065369,
-0.6304081082344055,
0.43349120020866394,
0.1777256727218628,
-0.11462395638227463,
0.4747953712940216,
0.04924236983060837,
-0.6568655371665955,
0.10712870955467224,
-0.2694474160671234,
-1.0508304834365845,
-1.1156034469604492,
0.39187684655189514,
-0.21080021560192108,
0.3013175129890442,
-0.02215932123363018,
-0.2811366319656372,
-0.37139707803726196,
-0.48152124881744385,
0.3146005868911743,
-0.023905877023935318,
0.2040567845106125,
-0.2825774848461151,
-0.6946139335632324,
0.10420634597539902,
0.7348901629447937,
-0.4308755397796631,
-0.3500937521457672,
-0.7078908085823059,
0.032581526786088943,
-0.06528077274560928,
-0.14389154314994812,
0.4443519115447998,
-0.3639358878135681,
-0.5161067247390747,
0.380062073469162,
0.3595781922340393,
0.2841747999191284,
-0.1788645088672638,
-0.1404784470796585,
-0.35559791326522827,
0.7628968358039856,
0.7743830680847168,
-0.26581716537475586,
0.2301884889602661,
0.248964324593544,
0.04240370914340019,
0.33601459860801697,
0.686220645904541,
-0.11663446575403214,
0.05191066861152649,
0.05023445561528206,
-5.926717758178711,
0.15985824167728424,
0.41227540373802185,
0.03696600720286369,
-0.06717564165592194,
-0.685660183429718,
-0.4523402154445648,
-0.00650072330608964,
0.6943573951721191,
-0.029640253633260727,
-0.2096613347530365,
-0.25302255153656006,
-0.2442178875207901,
0.3812408447265625,
0.215958833694458,
0.19777575135231018,
0.4026188850402832,
-0.5023983120918274,
0.30367109179496765,
0.43691158294677734,
0.02853456512093544,
0.1861387938261032,
-0.08519032597541809,
0.40896081924438477,
-0.1732265204191208,
0.446936696767807,
-0.3138706386089325,
0.4826297461986542,
-0.7074016332626343,
-0.14766176044940948,
-0.5846761465072632,
-0.09030564874410629,
-0.591183602809906,
-0.501499593257904,
-0.005868382286280394,
0.3856718838214874,
-0.028344735503196716,
-0.19734036922454834,
0.5262187719345093,
0.26671701669692993,
-0.3591674566268921,
0.4326573610305786,
-0.2670843005180359,
0.5088358521461487,
0.3468944728374481,
0.278751939535141,
0.9903849363327026,
0.050294771790504456,
-0.24699676036834717,
0.21231505274772644,
0.2671973407268524,
0.200454980134964,
0.8399147987365723,
-0.1555546373128891,
0.14770430326461792,
0.22617369890213013,
-0.34804847836494446,
-0.7687944769859314,
0.28784874081611633,
-0.1287899911403656,
-0.20163242518901825,
-0.1705934703350067,
0.31160253286361694,
0.3891797363758087,
-0.6762845516204834,
-0.03927423804998398,
-0.24367013573646545,
0.7660377025604248,
0.6083751916885376,
-0.11142442375421524,
0.4186219871044159,
0.13385175168514252,
-0.10049636662006378,
-0.7557066679000854,
-0.07680846005678177,
-0.09487045556306839,
-0.030416471883654594,
-0.056824762374162674,
-0.49155884981155396,
-0.19291633367538452,
-0.1154153123497963,
-0.0441974475979805,
0.0636155754327774,
0.12494843453168869,
0.5879583358764648,
-0.5662126541137695,
0.04872671514749527,
0.01690656691789627,
-0.14738738536834717,
0.15299998223781586,
-0.4060676395893097,
-1.2508771419525146,
0.4381316006183624,
-0.48191437125205994,
0.8022720813751221,
0.5865172743797302,
-0.029726622626185417,
0.0035025940742343664,
0.30741146206855774,
-0.19067350029945374,
0.10247617214918137,
0.15762104094028473,
-0.29479309916496277,
0.2469588965177536,
-0.14295031130313873,
0.6153372526168823,
-0.2612922787666321,
0.410405695438385,
0.3434380888938904,
-0.9637153744697571,
0.37005409598350525,
0.8671360015869141,
-0.07724590599536896,
0.5419739484786987,
-0.22870415449142456,
-0.195687398314476,
-0.13765989243984222,
-0.11901091784238815,
-0.3170420229434967,
-0.813113808631897,
-0.09001196175813675,
0.2522040605545044,
-0.1321377009153366,
-0.44381189346313477,
-0.1272321492433548,
0.337159663438797,
-0.034877993166446686,
-0.18754339218139648,
0.10602138191461563,
0.9518159627914429,
0.4172194004058838,
0.08056331425905228,
0.23670290410518646,
-0.26023632287979126,
0.598850429058075,
0.0900973454117775,
0.13066397607326508,
-0.677077054977417,
-0.3661991357803345,
0.04574254900217056,
0.3012562394142151,
0.02984621934592724,
-0.04079459235072136,
-0.1463468372821808,
0.3255300521850586,
-0.3803701400756836,
0.16178934276103973,
-0.2730391025543213,
-0.1169378012418747,
-0.32213449478149414,
-0.026793222874403,
-0.11395637691020966,
0.5738397836685181,
-0.14538982510566711,
-0.12061220407485962,
-0.4149736762046814,
-0.04234865680336952,
-0.3475729525089264,
-0.343759149312973,
-0.43574774265289307,
0.4395364224910736,
-0.5820834040641785,
-0.03472289443016052,
0.03676805645227432,
0.13348166644573212,
-0.3336793780326843,
-0.10264715552330017,
0.0874810665845871,
0.27708879113197327,
-0.2545282542705536,
-0.018138179555535316,
-0.6050015687942505,
0.09920167922973633,
0.16164147853851318,
0.14675846695899963,
0.012121990323066711,
-0.3198172152042389,
0.01902514323592186,
-0.26108139753341675,
0.07013783603906631,
-0.22209352254867554,
-0.2217928171157837,
-0.3744063675403595,
0.4201135039329529,
-0.04484299197793007,
0.3405519723892212,
-0.7450613975524902,
0.024716639891266823,
0.45330923795700073,
0.6937953233718872,
0.0752611756324768,
-0.832017183303833,
-0.045036546885967255,
0.5537779331207275,
-0.18164633214473724,
-0.35486695170402527,
0.25607869029045105,
-0.2295973151922226,
-0.02589963562786579,
-0.12025386095046997,
0.1403854638338089,
-0.2387540489435196,
-0.2451774626970291,
0.13782870769500732,
-0.5679054260253906,
-0.41225868463516235,
0.4581570625305176,
-0.20775218307971954,
-0.23662292957305908,
0.04961321875452995,
-0.18901465833187103,
-0.6870233416557312,
-0.5773178935050964,
0.18307825922966003,
-0.2945728302001953,
-0.38617920875549316,
-0.22496278584003448,
0.015849879011511803,
-0.268669992685318,
-0.2749374806880951,
0.03696984052658081,
-0.8148856163024902,
-0.38810479640960693,
-0.025172395631670952,
-0.1502196341753006,
0.04896705970168114,
0.22394172847270966,
-0.05397177115082741,
0.2469419240951538,
-0.03264225274324417,
-0.42337819933891296,
1.041951298713684,
-0.23077920079231262,
0.5565585494041443,
-0.31003889441490173,
0.608592689037323,
-0.7702485918998718,
0.08621510863304138,
-0.6096031665802002,
-0.02853826992213726,
0.29969823360443115,
0.2085707187652588,
-0.4000083804130554,
0.6077346205711365,
-0.518153965473175,
0.34654539823532104,
0.28409817814826965,
-0.6033403873443604,
-0.05450035631656647,
0.4529287815093994,
-0.6848151683807373,
0.0723842903971672,
0.20467908680438995,
-0.10367891937494278,
0.44089752435684204,
-0.36706554889678955,
0.18545079231262207,
-0.10165735334157944,
0.12503987550735474,
-0.046692509204149246,
-0.07009854167699814,
0.18909285962581635,
0.35962802171707153,
0.08282849192619324,
0.04460080713033676,
0.0568276047706604,
0.6421523094177246,
0.2641369700431824,
0.06410586833953857,
0.27596914768218994,
0.29972729086875916,
-0.7036498188972473,
-0.16414666175842285,
0.033663712441921234,
0.07351209223270416,
0.20434892177581787,
-0.46359142661094666,
-0.5439566373825073,
-0.9238333106040955,
0.7518335580825806,
-0.23520536720752716,
0.1129995658993721,
-0.23092907667160034,
0.11087613552808762,
-0.09935221821069717,
-0.9354085326194763,
0.16645683348178864,
0.17975454032421112,
-0.5378636717796326,
-0.5492104291915894,
0.41337937116622925,
0.5800880789756775,
0.10638631135225296,
-0.33817175030708313,
0.5746670961380005,
-0.022355975583195686,
-0.2026936411857605,
0.31927573680877686,
0.40780094265937805,
-0.05101113021373749,
-0.13658465445041656,
-0.8546320796012878,
-0.2016657441854477,
0.03351324796676636,
-0.1771748811006546,
-0.37395960092544556,
-0.03345078229904175,
-0.6526021361351013,
0.12836319208145142,
0.1983776092529297,
0.6344493627548218,
-0.4830472469329834,
0.00027233120636083186,
0.5377674102783203,
0.24042531847953796,
-0.018643002957105637,
0.20486709475517273,
-0.12828630208969116,
0.4258779287338257,
0.036379870027303696,
-0.12309711426496506,
0.968438446521759,
0.34873682260513306,
-0.10962457954883575,
-0.2355499267578125,
0.5139114856719971,
0.04202704504132271,
0.39189770817756653,
-0.1655423492193222,
0.05406373739242554,
0.7246348261833191,
0.09051239490509033,
0.22606003284454346,
0.4750409722328186,
-0.2502919137477875,
-0.41616392135620117,
0.3024485409259796,
-0.09973996132612228,
0.31970423460006714,
0.7033059597015381,
-0.14586137235164642,
-0.6549742221832275,
0.41837021708488464,
0.5309693217277527,
-0.09886568039655685,
0.3642052412033081,
0.17431573569774628,
0.18348105251789093,
-0.7551875710487366,
0.7793015241622925,
0.3865963816642761,
0.42172300815582275,
0.010295970365405083,
0.6963356733322144,
-0.21687792241573334,
-0.13037286698818207,
0.6820765137672424,
-0.027327176183462143,
-0.17987865209579468,
-0.07623502612113953,
0.5820028185844421,
0.35144758224487305,
0.09853458404541016,
-0.41020703315734863,
-1.1194757223129272,
0.6177181005477905,
0.2997124493122101,
-0.031544096767902374,
-0.06057187542319298,
-0.3863482177257538,
-0.5932437181472778,
-0.016541818156838417,
-0.17606118321418762,
0.8261231780052185,
0.457338809967041,
0.6508395075798035,
-0.0012006243923678994,
0.5394740104675293,
0.15253518521785736,
0.1912892609834671,
-0.43653446435928345,
0.17960892617702484,
-0.6596009135246277,
-0.2381877303123474,
0.01935752108693123,
-0.3261159658432007,
-0.1887521892786026,
0.29278498888015747,
0.3507181704044342,
0.19733290374279022,
-0.1805429607629776,
0.6191128492355347,
0.22348980605602264,
0.17281083762645721,
-0.2651877999305725,
-0.0181918703019619,
0.0824960470199585,
0.4466002881526947,
-0.030238976702094078,
0.28071486949920654,
0.23278141021728516,
0.2960681915283203,
0.18854571878910065,
0.32386285066604614,
-0.22935795783996582,
0.16373533010482788,
-0.31030547618865967,
0.3944079577922821,
-0.10205652564764023,
-0.27200567722320557,
0.2351718693971634,
0.1578563153743744,
-0.4197356700897217,
0.30079665780067444,
0.5369536876678467,
-0.018321508541703224,
-0.19461378455162048,
-0.057749275118112564,
0.5191723704338074,
-0.5366772413253784,
-0.2823029160499573,
-0.30010727047920227,
0.48116350173950195,
0.5730797052383423,
0.4100930392742157,
0.7864708304405212,
-0.25818997621536255,
0.06303063780069351,
-0.14138896763324738,
0.10440759360790253,
-0.022119775414466858,
-0.05415227636694908,
-0.4690716862678528,
-0.0709342360496521,
-0.22036102414131165,
-0.42220842838287354,
0.48474106192588806,
-0.46471768617630005,
0.4343828856945038,
-0.17350706458091736,
-0.04658008739352226,
0.04700089618563652,
0.530000627040863,
-0.028570136055350304,
0.434516042470932,
-0.6207054853439331,
0.6326807737350464,
0.35986989736557007,
-0.19263778626918793,
0.8151133060455322,
-0.0821625366806984,
-0.09531925618648529,
0.04366768151521683,
-0.11371362954378128,
0.5795555710792542,
-0.13917334377765656,
-0.04046087712049484,
-0.2095411717891693,
0.17678895592689514,
0.14281535148620605
] |
|
RNA pseudoknots are functional structure elements with key roles in viral and cellular processes. Prediction of a pseudoknotted minimum free energy structure is an NP-complete problem. Practical algorithms for RNA structure prediction including restricted classes of pseudoknots suffer from high runtime and poor accuracy for longer sequences. A heuristic approach is to search for promising pseudoknot candidates in a sequence and verify those. Afterwards, the detected pseudoknots can be further analysed using bioinformatics or laboratory techniques. We present a novel pseudoknot detection method called DotKnot that extracts stem regions from the secondary structure probability dot plot and assembles pseudoknot candidates in a constructive fashion. We evaluate pseudoknot free energies using novel parameters, which have recently become available. We show that the conventional probability dot plot makes a wide class of pseudoknots including those with bulged stems manageable in an explicit fashion. The energy parameters now become the limiting factor in pseudoknot prediction. DotKnot is an efficient method for long sequences, which finds pseudoknots with higher accuracy compared to other known prediction algorithms. DotKnot is accessible as a web server at http://dotknot.csse.uwa.edu.au. | [
0.00998467206954956,
0.023992465808987617,
0.007910153828561306,
0.034604769200086594,
-0.015557613223791122,
-0.021240761503577232,
0.010863151401281357,
-0.009854846633970737,
-0.01828659698367119,
0.0304952971637249,
-0.012983918190002441,
0.01074744388461113,
-0.00992107018828392,
0.005351367872208357,
-0.015312730334699154,
0.04242081195116043,
-0.01922345906496048,
0.0008572556544095278,
0.007236003410071135,
0.010843065567314625,
-0.0008882959373295307,
0.01053287461400032,
0.009308869019150734,
0.009948192164301872,
0.005499077029526234,
0.01615902967751026,
-0.0428612194955349,
-0.02517898567020893,
0.0015468799974769354,
0.0017713443376123905,
0.004139536526054144,
-0.008104258216917515,
0.012240205891430378,
0.0006473157554864883,
0.01097947545349598,
-0.00031104404479265213,
-0.00031291041523218155,
0.00994645431637764,
0.06808847934007645,
-0.003890193300321698,
0.006775516550987959,
-0.0011739721521735191,
0.003991752862930298,
0.005300250370055437,
-0.009059780277311802,
-0.02761896699666977,
0.003343496471643448,
0.017429891973733902,
-0.01969507709145546,
0.005429509095847607,
-0.019587429240345955,
0.023609675467014313,
-0.010164916515350342,
0.005998045206069946,
-0.006184568628668785,
-0.015015436336398125,
0.019515151157975197,
-0.00033479463309049606,
-0.03229658305644989,
-0.016844680532813072,
-0.0003349962644279003,
0.033001337200403214,
-0.024215389043092728,
-0.024201422929763794,
0.011545184999704361,
-0.06716229766607285,
0.0312681719660759,
0.03644266724586487,
-0.003276753704994917,
0.013884011656045914,
0.01536649465560913,
0.014641820453107357,
-0.0523565337061882,
0.0061730691231787205,
0.010843245312571526,
0.00786399282515049,
-0.02103256806731224,
-0.008054121397435665,
-0.009149126708507538,
0.020089872181415558,
-0.00676931906491518,
0.001143934205174446,
-0.0032101203687489033,
0.013382667675614357,
0.02045624516904354,
-0.007000179495662451,
-0.012044787406921387,
0.008211874403059483,
0.013858042657375336,
0.025038987398147583,
0.016532381996512413,
0.008071503601968288,
-0.00398032832890749,
0.03222225233912468,
0.006623266264796257,
-0.006047599948942661,
0.03188373148441315,
0.03466770052909851,
0.02439190074801445,
0.003265871200710535,
-0.01399722509086132,
0.03658265992999077,
0.022131413221359253,
-0.013406459242105484,
-0.009154625236988068,
0.012308051809668541,
0.033335696905851364,
0.00361336930654943,
0.019762255251407623,
0.00594920851290226,
0.006382733583450317,
-0.036894459277391434,
-0.024830050766468048,
-0.0017772831488400698,
-0.0002887314185500145,
0.010884249582886696,
-0.0000020330771803855896,
-0.009899459779262543,
0.010606590658426285,
-0.028764929622411728,
-0.022891199216246605,
0.0010155662894248962,
0.0013889861293137074,
0.012213509529829025,
0.011956284753978252,
-0.012208342552185059,
0.001991516910493374,
-0.008714135736227036,
0.015681013464927673,
-0.0016747245099395514,
-0.012973334640264511,
-0.0013817115686833858,
-0.015371277928352356,
-0.02148856222629547,
0.006265399977564812,
-0.006539384368807077,
0.020407890900969505,
0.009073478169739246,
0.0036149362567812204,
-0.024764399975538254,
0.005978642497211695,
0.00787198357284069,
0.0037446310743689537,
0.016438495367765427,
-0.024571489542722702,
0.006445176899433136,
0.022259248420596123,
0.009390311315655708,
-0.004261668771505356,
-0.03499627485871315,
0.008164986036717892,
-0.005986992735415697,
-0.021879173815250397,
-0.002468638587743044,
0.028452903032302856,
0.006009130273014307,
-0.026453152298927307,
-0.016023406758904457,
-0.012959243729710579,
-0.025753099471330643,
0.004966938868165016,
0.0036226105876266956,
0.002510705031454563,
0.008004205301404,
0.04718531295657158,
-0.01644868217408657,
0.023571554571390152,
0.005189802031964064,
-0.02652762085199356,
-0.0018811216577887535,
-0.0067148650996387005,
-0.004136940930038691,
-0.004110443405807018,
0.009252043440937996,
0.002264366950839758,
0.001847399165853858,
-0.022602172568440437,
0.0050439536571502686,
-0.008313674479722977,
0.06720930337905884,
0.03276001289486885,
0.042348455637693405,
-0.004390593618154526,
0.020314346998929977,
0.030895521864295006,
-0.038747113198041916,
-0.005945450626313686,
-0.0113034937530756,
0.016724832355976105,
0.003880697302520275,
-0.01589159108698368,
-0.008991353213787079,
-0.004018875304609537,
-0.0029430401045829058,
-0.020100712776184082,
0.0022540665231645107,
-0.0022425102069973946,
0.008175907656550407,
0.0002772182924672961,
-0.003741986583918333,
0.006586278323084116,
0.04407341033220291,
0.013466790318489075,
0.029840966686606407,
0.0016160402446985245,
-0.0019881166517734528,
-0.007389359176158905,
-0.0172143392264843,
0.0032075652852654457,
0.006280830129981041,
0.021267423406243324,
-0.031062865629792213,
-0.007891679182648659,
-0.016535436734557152,
0.03675980493426323,
0.007383422460407019,
0.007247604429721832,
0.022562019526958466,
-0.012361432425677776,
-0.013357083313167095,
-0.0023745479993522167,
0.004874588456004858,
0.020213810727000237,
-0.024362854659557343,
0.01905032806098461,
0.0007889820262789726,
0.01236714981496334,
0.015535717830061913,
-0.011245980858802795,
0.0027196111623197794,
0.007547379471361637,
-0.018034296110272408,
-0.010691696777939796,
-0.01901560090482235,
0.012085741385817528,
0.01007075048983097,
0.011503663845360279,
-0.021192949265241623,
0.01677214913070202,
-0.012631137855350971,
-0.02481609210371971,
0.0019906945526599884,
0.0182481836527586,
-0.012980862520635128,
0.009316163137555122,
-0.017173923552036285,
0.022263582795858383,
0.01373676210641861,
0.005008685402572155,
-0.005777895450592041,
0.006346520967781544,
-0.0025503886863589287,
0.024707479402422905,
-0.022350680083036423,
-0.013402552343904972,
0.007746807299554348,
0.03476177528500557,
0.007490427698940039,
0.0234675332903862,
-0.013321391306817532,
0.006852058693766594,
0.00302117015235126,
0.010901914909482002,
-0.023851942270994186,
-0.002833243226632476,
0.007996492087841034,
-0.004549849778413773,
0.001803235150873661,
-0.002491552382707596,
0.008089657872915268,
0.006459016352891922,
-0.015947962179780006,
-0.006596800405532122,
-0.08095640689134598,
-0.0043118540197610855,
0.009291145950555801,
-0.003707841271534562,
0.014863688498735428,
-0.014661071822047234,
-0.009032923728227615,
0.027595344930887222,
-0.021536994725465775,
-0.008688817732036114,
-0.0005837804637849331,
0.012757634744048119,
-0.01595293916761875,
0.0192795991897583,
0.00806230679154396,
-0.007554176263511181,
0.013815575279295444,
-0.0040887026116251945,
-0.030719315633177757,
-0.0155418049544096,
0.005387136712670326,
-0.012575243599712849,
-0.018604617565870285,
0.017350152134895325,
-0.034762877970933914,
0.022781066596508026,
0.021149717271327972,
0.005096019245684147,
-0.01581008918583393,
0.002649300266057253,
0.0005532568320631981,
-0.04127879440784454,
0.0014615552499890327,
0.004005207680165768,
0.03764871135354042,
-0.017649447545409203,
-0.032076396048069,
0.005391573533415794,
-0.019092200323939323,
0.028938820585608482,
-0.010320032015442848,
0.020341258496046066,
-0.010258818045258522,
0.012517125345766544,
-0.0032863153610378504,
0.033519234508275986,
-0.010758508928120136,
0.05459039658308029,
0.01427854597568512,
-0.024015579372644424,
0.022339338436722755,
0.00034791778307408094,
0.006546396762132645,
0.014993197284638882,
0.005039472132921219,
0.024962248280644417,
0.014787938445806503,
-0.001180553575977683,
-0.010002011433243752,
-0.0020833269227296114,
-0.024281810969114304,
0.006444726139307022,
0.02304031327366829,
-0.010224362835288048,
-0.010157601907849312,
-0.010109037160873413,
0.025709249079227448,
0.0038752397522330284,
-0.014121015556156635,
0.004758934024721384,
-0.005271873436868191,
0.009795784950256348,
-0.01958390511572361,
-0.010799340903759003,
-0.02334952913224697,
-0.013841480016708374,
-0.011906414292752743,
-0.01272112037986517,
-0.03312823921442032,
-0.00628361850976944,
0.010577663779258728,
0.0012684233952313662,
-0.011557475663721561,
-0.013763202354311943,
-0.017280766740441322,
0.014453887939453125,
0.00614437460899353,
-0.006702561862766743,
0.0062707108445465565,
-0.013395380228757858,
0.0006554671563208103,
-0.027046475559473038,
-0.010684123262763023,
0.006394123658537865,
-0.005656394176185131,
-0.0484769307076931,
-0.0004136417992413044,
-0.001020610798150301,
0.012056738138198853,
0.00963737815618515,
-0.027297992259263992,
-0.010572739876806736,
0.014694765210151672,
-0.01854388788342476,
-0.02204090729355812,
0.011950064450502396,
0.000637509161606431,
-0.023917749524116516,
-0.0008374790195375681,
-0.004156440030783415,
-0.009833011776208878,
-0.004359296523034573,
-0.013416631147265434,
0.024927180260419846,
0.006270052865147591,
-0.01836722530424595,
0.0011115267407149076,
0.010277335532009602,
0.07208912074565887,
0.019457653164863586,
0.006730398163199425,
-0.005170934367924929,
-0.021330714225769043,
-0.016017070040106773,
0.0128735126927495,
0.016959242522716522,
-0.0049259779043495655,
-0.022427167743444443,
0.01169679407030344,
-0.004618986509740353,
-0.007433049380779266,
-0.017628591507673264,
-0.012973381206393242,
-0.010332928970456123,
-0.003496930468827486,
0.008297713473439217,
-0.011322293430566788,
0.0039874473586678505,
-0.010016757994890213,
0.0002848152071237564,
0.003508332185447216,
-0.013511487282812595,
-0.03081359714269638,
-0.017501341179013252,
-0.010974578559398651,
-0.017815716564655304,
-0.0045781610533595085,
0.00926729291677475,
0.007283445447683334,
0.004069126211106777,
-0.00603511231020093,
-0.0201374813914299,
0.014781706966459751,
0.00046685035340487957,
0.023296674713492393,
-0.00004864879883825779,
-0.0006489926017820835,
0.013317182660102844,
0.016051258891820908,
-0.010528681799769402,
0.03369038552045822,
0.018796347081661224,
0.02612539380788803,
-0.0015303632244467735,
-0.014441832900047302,
-0.009108077734708786,
-0.010466569103300571,
-0.005122052039951086,
-0.003646648023277521,
0.0018282586243003607,
0.009860862046480179,
-0.010877533815801144,
-0.0006014071404933929,
-0.026515014469623566,
0.012240849435329437,
-0.013654736801981926,
-0.0021226583048701286,
-0.014012929052114487,
-0.02500639110803604,
-0.005230986513197422,
0.02907003089785576,
-0.011578762903809547,
0.02240562066435814,
-0.00034921756014227867,
0.012482013553380966,
-0.009473397396504879,
-0.007673300337046385,
-0.03132732957601547,
-0.007047551684081554,
0.020717507228255272,
-0.004116238094866276,
-0.011678198352456093,
-0.0074022202752530575,
-0.03709065169095993,
0.01136209536343813,
-0.010218778625130653,
0.007295314222574234,
0.0035297879949212074,
0.03198350965976715,
0.029816962778568268,
-0.050537463277578354,
-0.00630568154156208,
0.010270850732922554,
-0.0042978618294000626,
-0.03722655028104782,
-0.07433858513832092,
-0.04148184508085251,
-0.006814213469624519,
-0.003639834001660347,
-0.02864486165344715,
0.04010751098394394,
-0.005246256943792105,
-0.013801584020256996,
-0.027975406497716904,
-0.010289736092090607,
-0.002236342988908291,
-0.0006024542381055653,
0.0008446164429187775,
-0.0027181259356439114,
0.007873423397541046,
-0.004878308158367872,
-0.0029998221434652805,
0.010483878664672375,
0.004360029008239508,
0.013996952213346958,
0.016086235642433167,
0.005918111652135849,
-0.03979469835758209,
0.0005210177041590214,
-0.006646997295320034,
-0.08109347522258759,
-0.027420584112405777,
0.015419954434037209,
-0.02257585898041725,
-0.02083946391940117,
-0.006303932052105665,
0.01248228270560503,
-0.006279929541051388,
0.009541657753288746,
-0.01730220392346382,
-0.009838122874498367,
0.012504644691944122,
0.03752775862812996,
0.006124823819845915,
0.01462666504085064,
-0.008577046915888786,
0.00809051375836134,
0.022865671664476395,
-0.008384233340620995,
0.0019442038610577583,
-0.02483794465661049,
-0.00021187635138630867,
-0.008818063884973526,
-0.02282136119902134,
-0.018437135964632034,
-0.000017298385500907898,
-0.011226842179894447,
0.022772662341594696,
-0.014496632851660252,
-0.006868286523967981,
0.00625944510102272,
-0.0020784009248018265,
0.008602337911725044,
-0.02236120030283928,
0.0013100486248731613,
-0.011943625286221504,
0.014380895532667637,
-0.0009934138506650925,
0.005767056718468666,
-0.022744067013263702,
-0.00029709970112890005,
-0.01575293019413948,
0.017130721360445023,
0.01159835048019886,
-0.002795938402414322,
-0.012213123962283134,
0.004823558963835239,
-0.0045976717956364155,
0.013985436409711838,
-0.013760946691036224,
0.01041668001562357,
0.003964521922171116,
-0.003304451471194625,
-0.012960609048604965,
0.013260501436889172,
0.022356217727065086,
0.0008467619773000479,
0.007296374998986721,
0.021101832389831543,
0.014086827635765076,
0.01297937985509634,
0.03695787116885185,
-0.005786816589534283,
0.07197976112365723,
-0.032411836087703705,
-0.0008349437266588211,
-0.03379873186349869,
-0.010336208157241344,
0.0011297417804598808,
-0.02260397933423519,
-0.007213917560875416,
0.007311813533306122,
-0.019827555865049362,
0.002221437869593501,
-0.011065279133617878,
-0.02346755564212799,
0.004923298954963684,
0.013704783283174038,
0.0067278859205543995,
-0.009538537822663784,
0.001099277287721634,
-0.007291868794709444,
-0.017387520521879196,
0.007807911839336157,
0.030624888837337494,
-0.00499060470610857,
-0.010432368144392967,
-0.005326219834387302,
-0.007168838754296303,
0.009154416620731354,
0.011372122913599014,
-0.005702715367078781,
-0.0015289697330445051,
-0.014558462426066399,
-0.0014067506417632103,
0.0035233607050031424,
0.029842766001820564,
0.021546505391597748,
-0.023971254006028175,
0.020346399396657944,
0.0007645845762453973,
0.0012133009731769562,
-0.01347330491989851,
0.01233680546283722,
-0.002938678953796625,
-0.003090495243668556,
-0.017316196113824844,
-0.013577844947576523,
0.025860942900180817,
0.02140570431947708,
0.008696463890373707,
0.020774928852915764,
0.026316117495298386,
-0.019429337233304977,
0.003294136840850115,
0.012581483460962772,
0.01632104627788067,
0.0006876608240418136,
-0.03187306970357895,
-0.013992460444569588,
0.0038393016438931227,
-0.005099851172417402,
0.009009494446218014,
0.0024317477364093065,
-0.010900983586907387,
-0.004875109996646643,
-0.00788852572441101,
0.02777998335659504,
0.008837527595460415,
-0.027306709438562393,
-0.01088388729840517,
0.007808969356119633,
0.0168682262301445,
-0.02293490245938301,
0.007327662780880928,
0.0030998894944787025,
0.011404372751712799,
0.003444502828642726,
-0.018035560846328735,
0.008476867340505123,
0.0013172817416489124,
0.024983026087284088,
0.014063619077205658,
0.0034700334072113037,
0.001976560102775693,
0.011776464059948921,
-0.020200442522764206,
-0.02590133249759674,
0.002656431868672371,
-0.021603550761938095,
0.0020522386766970158,
0.0006379443220794201,
0.007204239256680012,
0.006781822070479393,
-0.00009552726987749338,
0.009643208235502243,
-0.0065831951797008514,
0.0034364163875579834,
0.03418400138616562,
0.02334916777908802,
0.011384591460227966,
-0.021507948637008667,
0.025630757212638855,
0.03699652850627899,
-0.016251660883426666,
-0.00514291413128376,
-0.006242722272872925,
-0.0002845395356416702,
0.0020267823711037636,
-0.014177851378917694,
0.03133070468902588,
0.018457312136888504,
-0.03498326241970062,
0.021632889285683632,
0.005525719374418259,
-0.004268786404281855,
0.018731629475951195,
-0.0013169366866350174,
0.014739453792572021,
-0.004878236912190914,
-0.004867475014179945,
0.024506110697984695,
-0.008478760719299316,
-0.02269841358065605,
-0.004581094719469547,
-0.006750704720616341,
0.018664488568902016,
0.009807225316762924,
-0.018985427916049957,
-0.002029536757618189,
-0.01798248663544655,
0.0028340136632323265,
-0.0031646634452044964,
0.01706570014357567,
0.011285360902547836,
0.0034898552112281322,
0.021220657974481583,
0.00004629092290997505,
0.007568479515612125,
0.010210514068603516,
-0.000843072310090065,
0.015545926056802273,
-0.0076279910281300545,
-0.015384365804493427,
-0.02330486848950386,
0.01266611646860838,
-0.020281637087464333,
0.007881298661231995,
-0.0003735987702384591,
0.024657610803842545,
0.027956949546933174,
0.004054117016494274,
-0.0037280372343957424,
0.011202224530279636,
0.024953175336122513,
-0.01796145550906658,
-0.004906895104795694,
0.002547123469412327,
0.009582404047250748,
0.008455870673060417,
0.019158408045768738,
-0.0035412441939115524,
0.02209445834159851,
0.010283183306455612,
0.018339231610298157,
-0.006723334081470966,
-0.008637758903205395,
0.014181642793118954,
0.0326913483440876,
-0.006406730972230434,
0.0239078551530838,
-0.025276754051446915,
-0.019126493483781815,
-0.004465420264750719,
-0.019536111503839493,
0.002277728635817766,
-0.004906085319817066,
-0.00966284703463316,
-0.02773994766175747,
-0.02447858639061451,
-0.024490302428603172,
-0.01976373977959156,
-0.004525868687778711,
0.009657778777182102,
-0.006175508722662926,
0.002546642441302538,
-0.013002719730138779,
-0.008341057226061821,
0.008385545574128628,
-0.0017690560780465603,
0.025359924882650375,
-0.004389879759401083,
0.009180158376693726,
-0.007591584697365761,
-0.014703113585710526,
-0.020735766738653183,
0.03003760054707527,
-0.00784694217145443,
0.010073579847812653,
-0.018073927611112595,
-0.0391228124499321,
0.014654748141765594,
0.012326051481068134,
-0.0002532191574573517,
-0.0071067409589886665
] | [
0.44483211636543274,
0.2734299600124359,
-0.29324111342430115,
-0.06215035542845726,
-0.04568001627922058,
-0.33275967836380005,
0.32481101155281067,
-0.38335761427879333,
-0.01133250817656517,
-0.4363219141960144,
0.14912207424640656,
0.02924691140651703,
-0.9479333162307739,
0.5226201415061951,
-0.28091663122177124,
0.29357343912124634,
0.438565194606781,
0.5061044096946716,
0.03483395650982857,
-0.41151222586631775,
-0.47720688581466675,
0.26426082849502563,
0.25924938917160034,
-0.04701833799481392,
0.2943134605884552,
0.17382527887821198,
0.5355788469314575,
-0.06018228828907013,
-0.19674043357372284,
-0.22617124021053314,
-0.010995304211974144,
0.7444279789924622,
0.2272801250219345,
-0.07090051472187042,
0.013515928760170937,
-0.18202969431877136,
-0.41420191526412964,
0.09831015020608902,
-0.05318760871887207,
-0.3511665463447571,
0.001455311430618167,
-0.209855318069458,
-0.2849544286727905,
0.5499556064605713,
-0.5151928067207336,
-0.7327662706375122,
-1.170189619064331,
0.8459242582321167,
-0.6994921565055847,
-0.10825350880622864,
-0.16750620305538177,
0.10170940309762955,
0.7987701296806335,
0.032998405396938324,
0.17214787006378174,
0.015170141123235226,
-0.35291817784309387,
-0.32429978251457214,
0.6494312286376953,
-0.35282689332962036,
0.22462168335914612,
-0.10034852474927902,
-0.6018378138542175,
0.2707071006298065,
0.19138218462467194,
0.6603416204452515,
0.37859442830085754,
-0.5827115178108215,
-0.9417169094085693,
0.0317830964922905,
0.48059606552124023,
-0.25396808981895447,
-0.14712966978549957,
0.17635364830493927,
-0.14377781748771667,
0.009144189767539501,
-0.07232163101434708,
0.37702950835227966,
0.07754959911108017,
-0.26687347888946533,
-0.1260884702205658,
0.20021496713161469,
-0.17352336645126343,
-0.30571335554122925,
0.2894897758960724,
0.06424219161272049,
-0.6857573390007019,
0.7106926441192627,
-0.6336793303489685,
-0.06443903595209122,
0.003592334222048521,
-0.14033649861812592,
-0.05125974491238594,
0.3652316927909851,
0.2725011706352234,
0.2268676906824112,
-0.24218863248825073,
0.1506337970495224,
0.32216009497642517,
0.5396686792373657,
-0.37892428040504456,
-0.3016371428966522,
0.2705053985118866,
-0.6862995028495789,
-0.2229289412498474,
0.03232299163937569,
-0.4676356613636017,
-0.5008848309516907,
-0.516663670539856,
0.18925456702709198,
-0.37611904740333557,
0.4914182722568512,
-0.14588646590709686,
-0.11577184498310089,
-0.2728065252304077,
-0.10824334621429443,
0.379814088344574,
-0.14845170080661774,
-0.35977134108543396,
0.03180030360817909,
-0.43828076124191284,
1.6966850757598877,
0.02949281595647335,
0.2572394013404846,
0.09372185170650482,
0.32806023955345154,
0.21128897368907928,
0.35839512944221497,
-0.7244325280189514,
0.3652467131614685,
0.3670625686645508,
1.5454118251800537,
-0.5133500099182129,
0.11281248182058334,
-0.2860276997089386,
-0.28936171531677246,
-0.11349007487297058,
0.142342671751976,
0.5939415097236633,
-0.3745361566543579,
-0.7015588283538818,
-0.5141170620918274,
-0.04271036386489868,
0.3488646149635315,
-0.22626841068267822,
-0.25441890954971313,
-0.23798462748527527,
-0.4089955985546112,
-0.16492384672164917,
0.11143394559621811,
-0.48947572708129883,
-0.5010632276535034,
-1.0825743675231934,
-0.043572571128606796,
0.09525062888860703,
0.09337625652551651,
0.21754375100135803,
-0.11320128291845322,
-0.02883429452776909,
0.593788743019104,
0.38027921319007874,
-0.05099952965974808,
-0.6552301049232483,
-0.32901790738105774,
0.6016741991043091,
-0.5441288948059082,
0.40026676654815674,
0.5032076835632324,
0.08148203045129776,
0.07513381540775299,
-0.22864599525928497,
-0.2708016335964203,
0.18930812180042267,
-0.5028939247131348,
-0.0891038104891777,
-0.2802867591381073,
0.01958402805030346,
-0.6377148032188416,
0.06237896531820297,
0.1873280107975006,
-0.9713801145553589,
-0.016843248158693314,
-0.04044478014111519,
-0.591809868812561,
0.40223607420921326,
0.7880418300628662,
0.3683728873729706,
0.2745641767978668,
0.015176478773355484,
-0.1201590895652771,
-0.5557962656021118,
-0.12620554864406586,
0.17274649441242218,
-1.0027731657028198,
1.1083437204360962,
0.24133948981761932,
0.00683814799413085,
1.8221036195755005,
0.051759567111730576,
-0.36930111050605774,
-0.3721642792224884,
0.22858627140522003,
0.46350640058517456,
-0.7328778505325317,
-0.29471567273139954,
0.074765644967556,
0.40084224939346313,
0.021790847182273865,
-0.19153927266597748,
-0.23300977051258087,
0.9861508011817932,
-0.3534224331378937,
-0.019081924110651016,
-0.5343988537788391,
0.02944214642047882,
-0.15585623681545258,
-0.03513810783624649,
0.04708563908934593,
-0.5042257308959961,
0.2929767370223999,
0.7153792381286621,
-0.8423998951911926,
0.4142448902130127,
0.8041956424713135,
-0.1079568862915039,
1.0206900835037231,
0.3485272526741028,
0.21675503253936768,
0.7607182264328003,
-0.19278979301452637,
0.3895324170589447,
-0.7692945003509521,
0.4461019039154053,
-0.32597440481185913,
-0.005268673412501812,
-0.060883522033691406,
0.18082770705223083,
0.10505834221839905,
0.1921897679567337,
0.027987832203507423,
0.1067047268152237,
0.3876589238643646,
-1.1086796522140503,
-0.1843663901090622,
0.19260592758655548,
-0.7134249210357666,
-0.20175206661224365,
-0.13858994841575623,
-0.3968164324760437,
0.05352868139743805,
0.15229029953479767,
0.3682999610900879,
0.6596865057945251,
-0.8528417348861694,
0.5884684324264526,
0.26449528336524963,
-0.2974475920200348,
-0.36635884642601013,
0.25248223543167114,
-0.15395605564117432,
-0.41938361525535583,
0.05002744495868683,
-0.1075739711523056,
0.03933039680123329,
-0.1644711047410965,
0.026997113600373268,
-0.1725194901227951,
-0.7355740666389465,
1.3045361042022705,
0.7128953337669373,
0.5370448231697083,
0.16062362492084503,
-0.7756755352020264,
-0.015300845727324486,
-0.21511393785476685,
-0.8868966698646545,
0.24778470396995544,
0.4039817452430725,
-0.5022168755531311,
-0.6966135501861572,
-0.19736507534980774,
0.3613232672214508,
0.4487208425998688,
-0.7926737070083618,
-0.7704877853393555,
-0.1188724935054779,
0.11741852015256882,
0.246805801987648,
-0.6378800868988037,
-0.05250346288084984,
-0.9105467200279236,
0.25856491923332214,
-0.5434908866882324,
-0.04392247274518013,
0.17111729085445404,
0.40473246574401855,
0.18589159846305847,
0.14586351811885834,
0.457359254360199,
-0.2707362473011017,
-0.014873815700411797,
0.45834067463874817,
-0.5293517708778381,
-0.27742648124694824,
-0.03183155506849289,
0.41760924458503723,
-0.021193793043494225,
0.576406717300415,
-5.566824913024902,
0.07985150814056396,
-0.1982196718454361,
-0.1933422088623047,
-0.2941860258579254,
0.022916311398148537,
0.7658042907714844,
-0.08289282023906708,
0.5651013851165771,
-0.32216209173202515,
0.14774715900421143,
-0.18162404000759125,
0.14551915228366852,
0.16556985676288605,
0.36990171670913696,
-0.10853561013936996,
0.6048310399055481,
0.3026334047317505,
0.5710058212280273,
0.3774647116661072,
0.36655130982398987,
0.3840891122817993,
0.0847414880990982,
0.14101538062095642,
-0.17735055088996887,
-0.6507269144058228,
-0.89329594373703,
0.11265243589878082,
-0.2307618409395218,
-0.7738701701164246,
0.10499344021081924,
-0.1811189204454422,
0.06853786110877991,
-0.3825570046901703,
0.11297664791345596,
0.0414232537150383,
-0.09322546422481537,
0.003406775649636984,
0.10785945504903793,
0.007037653122097254,
0.40094271302223206,
0.3052844703197479,
0.11073974519968033,
0.11227364093065262,
0.2959941029548645,
-0.037453193217515945,
-0.049728475511074066,
-0.1009935513138771,
-0.32578733563423157,
0.8985458016395569,
-0.2800924479961395,
-0.346566766500473,
0.8792540431022644,
0.5132935643196106,
0.35361748933792114,
-0.24157172441482544,
-0.08217575401067734,
0.19192595779895782,
-0.6077620983123779,
-0.035972706973552704,
-0.06844222545623779,
0.041650548577308655,
0.3313350975513458,
-0.8322581052780151,
-0.21930436789989471,
0.3014422357082367,
-0.8181944489479065,
-0.4612240195274353,
0.3471590280532837,
-0.013705003075301647,
-0.4948452413082123,
0.32221248745918274,
-0.0652511790394783,
-0.34976401925086975,
0.9097747206687927,
-0.17511332035064697,
0.5019566416740417,
0.03052760288119316,
0.029690884053707123,
0.0003557202871888876,
-0.5306921005249023,
-0.06304267048835754,
-0.3733128309249878,
-0.16338737308979034,
0.5820905566215515,
-0.6956838965415955,
-0.31046777963638306,
-0.2578461468219757,
-0.5593380928039551,
0.4730710983276367,
0.8690827488899231,
-0.20206744968891144,
0.15542444586753845,
0.5717633366584778,
0.7770594954490662,
-0.007364360615611076,
0.5059821009635925,
0.44017645716667175,
0.9060726165771484,
0.25821632146835327,
0.7998318672180176,
-0.041276223957538605,
-0.5600268840789795,
-0.9477918744087219,
0.08703626692295074,
0.040230732411146164,
-0.5280566811561584,
0.2604420483112335,
0.5211805701255798,
-0.3988339304924011,
0.15261925756931305,
0.17235742509365082,
-0.3316614627838135,
0.13701581954956055,
0.5121234655380249,
-0.12698373198509216,
0.19821257889270782,
-0.15823890268802643,
0.20249344408512115,
-0.4416576623916626,
0.24343973398208618,
0.4396991729736328,
-0.28699660301208496,
0.5959402322769165,
0.2981604337692261,
-0.5138846039772034,
0.24642299115657806,
0.310626357793808,
-0.22997954487800598,
-0.45046207308769226,
0.6197571158409119,
0.2551337778568268,
-0.6465086936950684,
-0.5512605309486389,
0.4743925631046295,
-0.23170205950737,
-0.6392724514007568,
-0.12270278483629227,
0.1469597965478897,
-0.6359026432037354,
0.43612977862358093,
-0.497221976518631,
0.04283588379621506,
0.496622234582901,
0.2660755515098572,
0.16416160762310028,
0.1662323772907257,
0.3660641014575958,
-0.0728100910782814,
-0.06309247761964798,
-0.528195858001709,
0.04036174342036247,
0.43650761246681213,
-0.5505971908569336,
-0.04295753315091133,
0.33265307545661926,
0.7313458919525146,
-0.022242235019803047,
0.49157413840293884,
-0.6905133128166199,
0.5002459287643433,
0.3660856783390045,
-0.27922168374061584,
0.48912909626960754,
-0.5917789340019226,
0.19876648485660553,
-0.42725104093551636,
0.2225169539451599,
-0.38180872797966003,
0.06550488620996475,
-0.4648462235927582,
0.01354188658297062,
-0.05982287973165512,
-0.3931925296783447,
0.2753576338291168,
0.18146610260009766,
0.06021422520279884,
0.5506315231323242,
-0.0222883652895689,
0.01861320063471794,
-0.2102687656879425,
-0.19239461421966553,
-0.012388506904244423,
0.695648729801178,
0.49456706643104553,
0.5085899829864502,
0.040282659232616425,
0.27927935123443604,
-0.7249302864074707,
-0.3730832040309906,
-0.048646558076143265,
0.4023715853691101,
0.6558331847190857,
-0.2599634826183319,
0.08562440425157547,
-0.1515401154756546,
0.0393485426902771,
0.44460585713386536,
0.06905762851238251,
-0.6411763429641724,
0.1467989981174469,
0.2930700480937958,
-0.3824467360973358,
0.2818742096424103,
0.027548473328351974,
0.08783350139856339,
-0.5327233076095581,
-0.11126144230365753,
0.3155967891216278,
-0.32005682587623596,
-0.46276775002479553,
-0.6681290864944458,
0.029278257861733437,
0.17763276398181915,
-0.247157022356987,
0.051695507019758224,
0.22018873691558838,
0.07997927069664001,
-0.20520994067192078,
0.13035115599632263,
0.14949151873588562,
-0.3044154942035675,
0.37278175354003906,
-0.0021135604474693537,
-0.15680530667304993,
0.5549079179763794,
-0.3435283899307251,
-0.8135294318199158,
0.12187297642230988,
0.15863408148288727,
-0.048317454755306244,
-0.1541087031364441,
0.09840293228626251,
-0.15406160056591034,
-0.4370608627796173,
-0.7928751111030579,
-0.2620764374732971,
0.2746521830558777,
0.047233231365680695,
0.42032262682914734,
0.1631065309047699,
0.6212543249130249,
-0.3361968994140625,
-0.5255126953125,
-0.2454557716846466,
0.4472603499889374,
0.43131840229034424,
-0.2712036669254303,
-1.0034059286117554,
0.07702111452817917,
0.44323113560676575,
0.2252684086561203,
-0.23078756034374237,
0.23391084372997284,
0.9889301061630249,
0.41692739725112915,
-0.2945132255554199,
-0.38117071986198425,
-0.022134331986308098,
0.305014967918396,
0.11487986892461777,
-0.09219278395175934,
-0.4521566331386566,
-0.3544831871986389,
0.6034857034683228,
-0.02684452012181282,
-0.5144506692886353,
-0.7285858392715454,
0.39948874711990356,
-0.2889368236064911,
-0.3125254511833191,
-0.05726546049118042,
0.5358853340148926,
0.7423836588859558,
-0.2855871319770813,
0.7788882255554199,
-0.1863863468170166,
0.3400552570819855,
-0.36289697885513306,
0.23024052381515503,
-0.4673350155353546,
-0.1462063193321228,
0.2315755933523178,
-0.5697505474090576,
-0.006251864600926638,
-0.15557707846164703,
-0.18837228417396545,
-0.11409268528223038,
0.26396432518959045,
-0.4779996871948242,
-0.37416183948516846,
-0.2684515118598938,
-1.097255825996399,
-0.03437412530183792,
0.15010623633861542,
0.21576276421546936,
0.2562582790851593,
0.1963004767894745,
-0.018194859847426414,
-0.4379115700721741,
-0.24757014214992523,
0.19548046588897705,
0.8342062830924988,
-1.0692154169082642,
0.3729105591773987,
-0.02055382914841175,
0.07645444571971893,
0.3788110911846161,
0.16718006134033203,
-0.1133425161242485,
0.18711702525615692,
0.16652795672416687,
0.29536494612693787,
0.17878474295139313,
-0.5905998945236206,
0.24211379885673523,
-0.20441186428070068,
0.05824001133441925,
0.7930496335029602,
0.011844790540635586,
0.2401498258113861,
0.25872164964675903,
0.15935267508029938,
0.005098212044686079,
-0.7497994899749756,
0.4386346936225891,
0.056519705802202225,
-0.3457821309566498,
-0.2875567376613617,
0.4125818610191345,
0.2139822542667389,
0.15979668498039246,
-0.2504688501358032,
0.18841975927352905,
-0.32912278175354004,
-0.04728198051452637,
-0.0757836401462555,
-0.38639703392982483,
-0.22317691147327423,
0.2554100751876831,
0.40867650508880615,
0.16059811413288116,
-0.6703027486801147,
0.26778852939605713,
0.18837910890579224,
0.3693602979183197,
0.48211780190467834,
0.10376764833927155,
-0.21370726823806763,
0.3996873199939728,
0.43879735469818115,
-0.009937220253050327,
-0.09987356513738632,
0.0037408077623695135,
-0.17676013708114624,
-0.23269107937812805,
0.6227644085884094,
-0.5783029198646545,
0.04090919718146324,
0.5138213634490967,
-0.16237543523311615,
0.4723109304904938,
-0.5087108612060547,
0.7384800910949707,
-0.24516935646533966,
-0.04771982133388519,
0.4168776571750641,
0.2257327288389206,
0.22718127071857452,
-0.4342593848705292,
0.3704630434513092,
-0.05870383605360985,
-0.5958573818206787,
0.8034983277320862,
-0.39291638135910034,
-0.5146222114562988,
-0.08191648125648499,
0.20193210244178772,
-0.10511212050914764,
-0.20303525030612946,
-0.17153654992580414,
0.5303215980529785,
0.016787320375442505,
-0.5342531800270081,
-0.30046775937080383,
-0.4426170885562897,
-0.34309354424476624,
-0.12267395108938217,
0.5155701041221619,
0.048334941267967224,
0.43798285722732544,
-1.0154438018798828,
-0.29980677366256714,
0.020919881761074066,
-0.050249289721250534,
-0.06931131333112717,
0.06545736640691757,
0.8828927874565125,
0.44324007630348206,
0.45042684674263,
-0.2883276045322418,
0.407444566488266,
0.2447293996810913,
0.6061028838157654,
-0.6629441976547241,
0.5753899216651917,
-0.2319193333387375,
-0.27281126379966736,
-0.5971118211746216,
0.04876870661973953,
0.6955136060714722,
0.5067083835601807,
0.06700493395328522,
0.17683576047420502,
0.5479798913002014,
-0.07561387121677399,
0.0749596655368805,
-0.7452821731567383,
0.09431646764278412,
-0.2334383875131607,
-0.22908279299736023,
-0.4564392566680908,
0.3867325782775879,
-0.17364290356636047,
-0.3079882860183716,
-0.13195593655109406,
-0.23076274991035461,
0.41881805658340454,
-0.7937102913856506,
0.19580307602882385,
0.06220860406756401,
-0.33884966373443604,
-0.5360109210014343,
0.6487395763397217,
-0.3807723820209503,
-0.06048833206295967,
-0.13056601583957672,
0.5063155889511108,
0.4135251045227051,
0.06898050755262375,
-0.10796593874692917,
0.024347620084881783,
-0.27680718898773193,
0.10568985342979431,
0.050629496574401855,
0.4682231545448303,
0.05787884071469307,
-0.32298052310943604,
-0.8242101669311523,
0.036348164081573486,
0.12190372496843338,
-0.08590996265411377,
-0.47976747155189514,
0.26361826062202454,
-0.6091148853302002,
-0.2983815371990204,
0.02066686935722828,
-0.5079768896102905,
-0.036439161747694016,
0.02626725845038891
] |
The United States is the world’s largest wildlife importer, and imported wild animals represent a potential source of zoonotic pathogens. Using data on mammals imported during 2000–2005, we assessed their potential to host 27 selected risk zoonoses and created a risk assessment that could inform policy making for wildlife importation and zoonotic disease surveillance. A total of 246,772 mammals in 190 genera (68 families) were imported. The most widespread agents of risk zoonoses were rabies virus (in 78 genera of mammals), Bacillus anthracis (57), Mycobacterium tuberculosis complex (48), Echinococcus spp. (41), and Leptospira spp. (35). Genera capable of harboring the greatest number of risk zoonoses were Canis and Felis (14 each), Rattus (13), Equus (11), and Macaca and Lepus (10 each). These findings demonstrate the myriad opportunities for zoonotic pathogens to be imported and suggest that, to ensure public safety, immediate proactive changes are needed at multiple levels. | [
0.0021586513612419367,
0.00428288197144866,
-0.01411209162324667,
0.011553080752491951,
0.03637027367949486,
0.027506375685334206,
0.008430159650743008,
-0.0004515990149229765,
-0.016033437103033066,
-0.018855702131986618,
0.013469969853758812,
0.009017210453748703,
0.008450960740447044,
0.014891156926751137,
0.013112476095557213,
0.007571914698928595,
-0.0152105912566185,
-0.01913360506296158,
0.013927227817475796,
-0.004639150574803352,
-0.0048113493248820305,
0.006100875325500965,
0.008544555865228176,
0.0043617901392281055,
0.00023815722670406103,
-0.0015214313752949238,
0.023699931800365448,
0.01234471146017313,
-0.014826865866780281,
0.004205969162285328,
0.025245776399970055,
0.010011928156018257,
-0.006114008836448193,
-0.0329454280436039,
0.01580740138888359,
-0.018524641171097755,
0.001878982875496149,
0.010212598368525505,
-0.021145369857549667,
-0.0029508310835808516,
0.0161893367767334,
-0.008655876852571964,
-0.004526921547949314,
-0.0013216654770076275,
-0.0055484529584646225,
-0.011111796833574772,
-0.010791197419166565,
-0.004400248173624277,
-0.0018349820747971535,
0.017672590911388397,
-0.005232426803559065,
-0.028797807171940804,
-0.018352527171373367,
0.008815567009150982,
-0.006672637537121773,
-0.010526127181947231,
0.018800698220729828,
0.005650459788739681,
0.007420272100716829,
-0.01311795599758625,
-0.015288814902305603,
0.028889581561088562,
0.009313862770795822,
0.00845094583928585,
-0.0021528727374970913,
-0.06709695607423782,
0.012916505336761475,
0.00905279628932476,
0.0018135756254196167,
0.02424444630742073,
0.0030732150189578533,
0.00573794124647975,
-0.011409135535359383,
-0.014267944730818272,
-0.005458168685436249,
0.025822866708040237,
-0.0037655914202332497,
0.005725841503590345,
0.021392587572336197,
-0.0064963772892951965,
-0.000037139980122447014,
-0.022300736978650093,
0.007625048514455557,
0.021563757210969925,
-0.010044008493423462,
0.015072030015289783,
-0.035580940544605255,
-0.008857590146362782,
-0.008567143231630325,
0.005779026076197624,
0.029379364103078842,
0.027908721938729286,
-0.009608488529920578,
-0.012609336525201797,
-0.013221644796431065,
-0.02991928532719612,
-0.006248504854738712,
-0.025577697902917862,
0.010391950607299805,
-0.0021808543242514133,
0.00888086762279272,
-0.001482315012253821,
0.012462334707379341,
0.04279208928346634,
-0.0014198817079886794,
0.011323846876621246,
0.012769429013133049,
-0.0007515253964811563,
0.01022341288626194,
0.0014959840336814523,
0.011060144752264023,
0.02953728660941124,
-0.015386531129479408,
0.01699773222208023,
-0.009182208217680454,
-0.02547163888812065,
0.02535085380077362,
0.017443016171455383,
0.0011441402602940798,
0.01341186836361885,
-0.011853020638227463,
0.01864542067050934,
-0.023807954043149948,
0.0378110408782959,
0.002130393171682954,
0.04573069512844086,
0.026997070759534836,
0.0285164937376976,
0.012610445730388165,
0.010699017904698849,
-0.004354925360530615,
-0.0049929749220609665,
-0.020688865333795547,
-0.013789231888949871,
0.01834893226623535,
-0.0006269593723118305,
0.036857232451438904,
-0.007032196037471294,
-0.00615424569696188,
0.018599368631839752,
-0.007347878068685532,
0.009495502337813377,
0.005878926254808903,
0.009669948369264603,
0.014655018225312233,
0.0032213430386036634,
-0.009670304134488106,
0.02504837140440941,
0.02107902616262436,
0.004929607268422842,
-0.031158605590462685,
-0.004970586858689785,
0.0014434333425015211,
-0.026069212704896927,
-0.009106067009270191,
-0.014193510636687279,
0.006435105577111244,
-0.02444414235651493,
0.015791885554790497,
-0.001288662664592266,
0.023199565708637238,
0.03898466378450394,
0.015986301004886627,
0.007632758002728224,
-0.00891832821071148,
-0.017722729593515396,
0.02165326476097107,
0.014731815084815025,
-0.012990592047572136,
0.0049433400854468346,
-0.0011799007188528776,
-0.011746819131076336,
0.01983061246573925,
0.009061567485332489,
0.00008300598710775375,
-0.01144181564450264,
0.017107607796788216,
0.00851794146001339,
0.002280919346958399,
0.06700174510478973,
0.04206745699048042,
0.027487080544233322,
-0.02235141023993492,
0.001625938806682825,
0.008340793661773205,
-0.011651609092950821,
0.015474142506718636,
-0.011278796941041946,
-0.030129754915833473,
-0.024016590788960457,
0.002957418328151107,
0.011520345695316792,
0.018734723329544067,
-0.011495589278638363,
-0.0005371416918933392,
0.004632811527699232,
0.020156029611825943,
0.005885530263185501,
-0.007291971705853939,
0.004718750715255737,
0.03350742533802986,
0.012784923426806927,
0.018547004088759422,
-0.043495699763298035,
-0.02353733591735363,
0.00900951586663723,
0.013509392738342285,
0.024759525433182716,
-0.003123563714325428,
-0.018684381619095802,
0.013616153039038181,
-0.020099429413676262,
-0.004268018063157797,
-0.025053950026631355,
-0.004984882194548845,
0.007925257086753845,
0.001833129208534956,
-0.004233000800013542,
0.001285226084291935,
-0.015111506916582584,
-0.009045585058629513,
-0.00551264826208353,
-0.0020487960427999496,
-0.002072380855679512,
0.009510274976491928,
-0.0005835514748468995,
0.023396417498588562,
0.0049629537388682365,
-0.0035073633771389723,
-0.0012280376395210624,
0.002450636588037014,
-0.014756828546524048,
-0.008342931978404522,
0.0070121875032782555,
0.010174108669161797,
0.009330209344625473,
0.008759083226323128,
0.012995456345379353,
0.010981207713484764,
-0.00802040845155716,
0.0028251686599105597,
-0.010796872898936272,
-0.009296895936131477,
-0.007193971890956163,
0.03936970233917236,
-0.029216978698968887,
0.043566714972257614,
0.007316542323678732,
0.005910074338316917,
-0.006799838040024042,
0.006516387686133385,
-0.0014268453232944012,
0.026599273085594177,
-0.00535173574462533,
-0.005597210489213467,
-0.00508241169154644,
-0.016843140125274658,
0.0036795749329030514,
0.025417547672986984,
0.02557004615664482,
0.015218599699437618,
0.0046940757893025875,
-0.016470253467559814,
-0.003754447679966688,
0.025687824934720993,
-0.004068560898303986,
0.03447357565164566,
0.002783298958092928,
0.0038325279019773006,
0.01743018627166748,
0.005097122397273779,
-0.005003969185054302,
0.001828481676056981,
-0.08184456825256348,
0.0027645532973110676,
0.013532042503356934,
-0.016134018078446388,
0.010024573653936386,
0.019802886992692947,
0.014031186699867249,
0.004974559415131807,
0.008234485983848572,
0.017161458730697632,
-0.003903967095538974,
0.003957749344408512,
-0.0014425397384911776,
-0.020211461931467056,
-0.006299962289631367,
-0.00876476801931858,
0.002534924540668726,
-0.01618700474500656,
-0.01188678853213787,
-0.051662858575582504,
0.005342305637896061,
0.004716326482594013,
-0.0027252580039203167,
-0.0213030856102705,
0.00477477815002203,
-0.009665664285421371,
0.0036331333685666323,
0.0048165591433644295,
0.018522201105952263,
0.00040866294875741005,
0.0056369490921497345,
0.007632791996002197,
0.0006271163001656532,
-0.004264598712325096,
-0.00648113526403904,
0.0007602802943438292,
-0.0030457063112407923,
0.007118398789316416,
-0.005793937481939793,
0.006311613135039806,
0.0005236124852672219,
0.00876675546169281,
0.0183637086302042,
-0.01664920151233673,
0.0046120984479784966,
0.016518328338861465,
-0.030450979247689247,
-0.003935860004276037,
0.013072413392364979,
-0.0004880799097009003,
0.03044946864247322,
-0.011870017275214195,
0.017934229224920273,
0.005256460048258305,
-0.01592269167304039,
0.003968303557485342,
0.005254215560853481,
-0.018940456211566925,
-0.011365690268576145,
-0.00716073764488101,
-0.05239617079496384,
0.002696588635444641,
0.031247541308403015,
-0.008259247988462448,
-0.02284131571650505,
0.020370246842503548,
0.016506467014551163,
-0.0006936746649444103,
-0.01504305750131607,
-0.0028490829281508923,
0.024258539080619812,
-0.010053691454231739,
-0.012796195223927498,
-0.014553060755133629,
0.015239817090332508,
-0.007516356185078621,
-0.013885358348488808,
0.003468976588919759,
-0.003130395198240876,
-0.008647443726658821,
0.008455276489257812,
-0.0007157830987125635,
-0.030324416235089302,
0.011501566506922245,
-0.014328979887068272,
0.013590139336884022,
0.011310056783258915,
0.023464463651180267,
0.011602995917201042,
-0.009958093985915184,
0.02016262710094452,
0.0014173518866300583,
0.0061150602996349335,
0.006150839384645224,
-0.01287599466741085,
0.0033884630538523197,
0.02399267628788948,
-0.00016178912483155727,
0.015439040958881378,
0.00820695236325264,
0.0023468071594834328,
-0.010788822546601295,
0.0007760534062981606,
-0.011765030212700367,
0.006700417026877403,
0.01609015464782715,
0.005808033049106598,
-0.0030930566135793924,
0.009731348603963852,
-0.01264926791191101,
-0.002351700095459819,
-0.014686173759400845,
-0.0005356802721507847,
0.021645747125148773,
0.01859014853835106,
0.015230311080813408,
-0.006250488571822643,
-0.0037049425300210714,
0.07188186049461365,
0.010491432622075081,
0.0003317577065899968,
-0.013102514669299126,
0.011743969283998013,
-0.016148708760738373,
-0.009760267101228237,
0.00992315448820591,
0.025086618959903717,
-0.016589615494012833,
0.013338854536414146,
-0.014171099290251732,
0.0019186966819688678,
-0.056557923555374146,
0.0008921322878450155,
0.033627789467573166,
0.008188249543309212,
-0.003145255148410797,
-0.0022442545741796494,
0.018031198531389236,
0.002649127971380949,
0.015182927250862122,
0.004365282133221626,
0.008701931685209274,
-0.0009838875848799944,
-0.02603672817349434,
0.03304911404848099,
-0.008915374055504799,
0.002607882022857666,
0.0055438750423491,
0.023460935801267624,
0.003905062796548009,
-0.0045076338574290276,
0.011359691619873047,
-0.03030809387564659,
0.006520874332636595,
0.0022399993613362312,
0.005307158455252647,
-0.010995686985552311,
-0.0019730948843061924,
0.0070593953132629395,
-0.010595843195915222,
-0.017969097942113876,
0.00843794271349907,
-0.028470918536186218,
0.0031988518312573433,
-0.0026966817677021027,
-0.001426903996616602,
0.0008214687695726752,
0.0013853092677891254,
0.012195523828268051,
0.011205934919416904,
0.0026392305735498667,
0.011596585623919964,
0.008193762972950935,
-0.009321983903646469,
0.016124919056892395,
-0.005816781893372536,
-0.0008054831996560097,
-0.03181086480617523,
-0.0008329430711455643,
0.010085604153573513,
0.013519134372472763,
0.00035322667099535465,
-0.02738318219780922,
-0.022013336420059204,
-0.0038594594225287437,
0.004601230379194021,
0.007409116718918085,
-0.02308003231883049,
0.026780318468809128,
0.018592078238725662,
-0.005943860858678818,
-0.008566861040890217,
-0.03278869017958641,
0.028370589017868042,
-0.04408915340900421,
0.005720416083931923,
-0.005927490536123514,
0.0125240134075284,
-0.007834617979824543,
-0.004950095899403095,
0.03411681950092316,
-0.012170324102044106,
0.015570063143968582,
0.011967712081968784,
-0.026093021035194397,
-0.07491247355937958,
-0.0173506923019886,
0.011287174187600613,
-0.004786141216754913,
0.020917825400829315,
-0.014253263361752033,
-0.0180780291557312,
-0.015179648995399475,
-0.003394769039005041,
-0.021519336849451065,
0.015775352716445923,
0.0015944635961204767,
0.005138013511896133,
0.0027161044999957085,
0.016316290944814682,
0.021038159728050232,
-0.011577176861464977,
0.013448964804410934,
-0.03661707788705826,
-0.007646569050848484,
0.00047943927347660065,
0.017551466822624207,
-0.007842633873224258,
0.006426089443266392,
-0.019240690395236015,
-0.08084927499294281,
0.02142764814198017,
0.020827647298574448,
-0.004172941669821739,
-0.00038768118247389793,
0.014552529901266098,
0.004224687814712524,
-0.0059530772268772125,
-0.02366303652524948,
-0.013712329789996147,
0.0060645886696875095,
-0.01756272278726101,
0.0127924969419837,
-0.02219066396355629,
0.01977960392832756,
-0.005563235841691494,
0.014461595565080643,
0.017811767756938934,
0.02105044573545456,
-0.005344480276107788,
-0.010576169937849045,
-0.008114878088235855,
-0.006410944275557995,
-0.02243804931640625,
-0.0028609291184693575,
-0.0054214950650930405,
-0.012501958757638931,
0.00025328114861622453,
-0.006283042952418327,
0.004642193205654621,
0.003601323813199997,
0.017828427255153656,
-0.007600713055580854,
-0.02340865693986416,
0.015383104793727398,
-0.019558504223823547,
0.01198204793035984,
-0.004680634941905737,
0.01647036150097847,
-0.02193780429661274,
-0.011070642620325089,
-0.013784781098365784,
-0.021861881017684937,
-0.00013414397835731506,
0.02024490386247635,
-0.008494551293551922,
0.011534157209098339,
-0.01086565013974905,
0.02133835293352604,
0.009374113753437996,
0.01600937731564045,
0.03482611104846001,
0.023876462131738663,
0.004686050117015839,
0.019207341596484184,
-0.006112116388976574,
-0.004324352368712425,
-0.005798623897135258,
0.012907827273011208,
0.023710492998361588,
0.0107912328094244,
-0.00505842175334692,
-0.014631116762757301,
0.07203563302755356,
-0.009695563465356827,
0.0038037486374378204,
0.01719030737876892,
0.006498188246041536,
0.000037406571209430695,
0.023562416434288025,
0.02049298770725727,
0.018316855654120445,
-0.02708076499402523,
-0.014007266610860825,
0.00037616491317749023,
-0.0006993343122303486,
0.0072007691487669945,
0.015448691323399544,
0.0021384060382843018,
-0.03137894719839096,
0.014256052672863007,
-0.011645538732409477,
0.0225452221930027,
-0.04261007532477379,
-0.02100101113319397,
-0.019926004111766815,
0.0039373887702822685,
-0.014051789417862892,
-0.006429946981370449,
-0.004619623068720102,
0.029117707163095474,
-0.007112514227628708,
0.014378744177520275,
0.0021180668845772743,
0.006108170375227928,
0.011233163997530937,
0.003688355442136526,
0.038968153297901154,
0.018320079892873764,
0.018427575007081032,
0.008004987612366676,
-0.00971284881234169,
0.03584359586238861,
-0.011191526427865028,
0.0008121323771774769,
0.014394009485840797,
0.03168322145938873,
0.025893835350871086,
-0.012431181035935879,
0.017197944223880768,
-0.002319968305528164,
-0.003538736142218113,
0.001184461172670126,
-0.027543935924768448,
0.010329047217965126,
-0.000932860653847456,
0.007683228235691786,
-0.004476894624531269,
0.01155797578394413,
-0.010339613072574139,
0.009824048727750778,
-0.010750207118690014,
-0.022804858162999153,
-0.001554987276904285,
0.007875126786530018,
-0.02713055908679962,
-0.005569865927100182,
0.014344766736030579,
-0.026000944897532463,
0.005106568802148104,
-0.009875467047095299,
0.014704105444252491,
0.007644877303391695,
-0.010624123737215996,
0.00390560831874609,
0.005526220425963402,
0.012870172038674355,
0.018648643046617508,
0.015894416719675064,
-0.0078076813369989395,
-0.0022021562326699495,
0.003512565977871418,
0.010448029264807701,
-0.018873073160648346,
-0.005388156045228243,
0.021805739030241966,
-0.032372329384088516,
0.005058129318058491,
0.003984608221799135,
0.011962279677391052,
0.01660601794719696,
-0.008220260962843895,
-0.001751365838572383,
-0.013344384729862213,
0.0027950573712587357,
0.004497749265283346,
0.011509738862514496,
0.008799875155091286,
0.03597360849380493,
-0.00843008141964674,
-0.00006908806972205639,
0.002776630688458681,
-0.00265651592053473,
0.013243896886706352,
-0.014436854980885983,
0.02707630768418312,
-0.007710610516369343,
-0.0029183444567024708,
0.013952994719147682,
-0.009108785539865494,
0.018063005059957504,
0.0330948606133461,
0.0008042214903980494,
0.029362371191382408,
0.0035083305556327105,
0.007762894034385681,
-0.015106488950550556,
-0.010101726278662682,
0.0035738246515393257,
0.005739796441048384,
0.03222319483757019,
-0.009057113900780678,
-0.011728554964065552,
-0.013499269261956215,
-0.01878627948462963,
0.018009068444371223,
0.023244207724928856,
0.027118653059005737,
0.013029424473643303,
-0.006822108291089535,
-0.014730258844792843,
-0.0010584197007119656,
-0.002854504156857729,
0.016055438667535782,
-0.06014825403690338,
0.012320040725171566,
-0.011218003928661346,
-0.013436267152428627,
0.027920370921492577,
0.0046919360756874084,
-0.023579977452754974,
0.007347141858190298,
-0.016940578818321228,
-0.004196982830762863,
-0.005558236036449671,
0.01987791433930397,
-0.0035200435668230057,
0.008534951135516167,
-0.008937004022300243,
0.019507626071572304,
0.027163147926330566,
0.009705922566354275,
-0.008439198136329651,
-0.0005521639250218868,
-0.0011118585243821144,
0.007812111172825098,
-0.00362016842700541,
0.012179149314761162,
-0.0007411236874759197,
0.010404305532574654,
-0.008787767961621284,
0.009912152774631977,
0.0090573038905859,
0.009886523708701134,
-0.0029538217931985855,
-0.013546416535973549,
-0.0001764153130352497,
-0.006982029881328344,
0.005110060330480337,
-0.004219858907163143,
-0.010438269004225731,
-0.0064794206991791725,
0.03900512307882309,
-0.013069678097963333,
0.0003126785159111023,
-0.025645913556218147,
0.017015254124999046,
-0.013098600320518017,
-0.006286200135946274,
-0.01675589382648468,
0.016210656613111496,
-0.02616836130619049,
0.01741677150130272,
0.026035385206341743,
0.018943624570965767,
0.004858366213738918,
-0.012834652327001095,
-0.0046526407822966576,
-0.01108998991549015,
-0.008871762081980705,
-0.01504602376371622,
0.012176763266324997,
-0.007374427281320095,
-0.021649183705449104,
-0.024808790534734726,
-0.0020517040975391865,
-0.012234856374561787,
-0.030416343361139297,
-0.012365671806037426,
-0.02000148594379425,
-0.045386042445898056,
0.01602545566856861,
0.0014636956620961428,
-0.004493187181651592,
0.002271529519930482
] | [
0.3680752217769623,
-0.20663782954216003,
-0.252319872379303,
-0.032444633543491364,
0.21849054098129272,
0.09948050230741501,
0.4034614562988281,
0.7747272849082947,
-0.6087353229522705,
-0.16428254544734955,
0.21709302067756653,
0.18135914206504822,
-1.1108617782592773,
0.8851190805435181,
-0.1572059690952301,
0.4876211881637573,
0.4750426113605499,
0.7004880905151367,
-0.05099794268608093,
-0.4075278341770172,
-0.39373159408569336,
-0.41840964555740356,
0.13336043059825897,
-0.048260852694511414,
0.25353097915649414,
-0.2048494964838028,
0.07680846005678177,
-0.30269289016723633,
-0.23163382709026337,
-0.019663088023662567,
0.4035209119319916,
0.2275129109621048,
-0.18186691403388977,
0.08178378641605377,
-0.16391979157924652,
0.18038271367549896,
-0.5096086263656616,
-0.1695745438337326,
0.06241759657859802,
-0.2739028334617615,
-0.35022616386413574,
0.02374584972858429,
-0.23880742490291595,
0.33476772904396057,
-0.1247251108288765,
-0.5443705916404724,
-0.7682313323020935,
1.0839941501617432,
0.038744792342185974,
0.6226450800895691,
-0.2530747652053833,
0.10564939677715302,
-0.3677707314491272,
0.3386760950088501,
0.06876659393310547,
0.5298050045967102,
-0.8000714182853699,
-0.09530633687973022,
-0.36302006244659424,
-0.4830794036388397,
0.11019249260425568,
-0.14198032021522522,
0.5168379545211792,
0.46145161986351013,
-0.2302623689174652,
0.687667191028595,
0.1857302188873291,
0.29965126514434814,
0.07897815108299255,
-0.5759665966033936,
-0.3127365708351135,
-0.7542179822921753,
-0.48462241888046265,
-0.10350888967514038,
0.13312427699565887,
-0.3709961473941803,
-0.2953064739704132,
-0.34036949276924133,
0.21900659799575806,
0.3686012029647827,
0.2485460340976715,
0.24090547859668732,
0.269263356924057,
-0.4649163484573364,
0.3934456408023834,
0.08248873800039291,
-0.04480556771159172,
0.5560682415962219,
0.3449941873550415,
0.11672891676425934,
0.37930551171302795,
0.5494775176048279,
0.31039905548095703,
-0.14368613064289093,
0.10315319150686264,
-0.31818515062332153,
0.08429458737373352,
-0.4707871377468109,
-0.031687669456005096,
0.05034227296710014,
-0.2627825140953064,
0.09375536441802979,
0.6383100152015686,
-0.05665907636284828,
-0.13526616990566254,
0.06567367166280746,
0.02010134607553482,
-0.4631974399089813,
0.20755022764205933,
0.16987061500549316,
0.15965501964092255,
-0.2658115327358246,
0.01600600779056549,
-0.35483697056770325,
-0.5015646815299988,
0.44717109203338623,
0.5949048399925232,
-0.44913896918296814,
0.31607380509376526,
-0.1986793577671051,
-0.24212101101875305,
0.08436824381351471,
-0.28245463967323303,
-0.043287891894578934,
-0.2819420099258423,
-0.4017426371574402,
0.3062972128391266,
-0.19647099077701569,
-0.13290709257125854,
-0.16140863299369812,
0.17843647301197052,
0.601669192314148,
-0.0887623205780983,
0.37492626905441284,
-0.21724146604537964,
0.007174966391175985,
0.14365079998970032,
0.3471628427505493,
0.4804638624191284,
-0.367178738117218,
-0.45436257123947144,
-0.8550354242324829,
-0.4253218173980713,
-0.36358508467674255,
-0.1981285959482193,
-0.4190083146095276,
-0.17546838521957397,
-0.2759712338447571,
-0.7525753378868103,
-0.008437687531113625,
0.045161981135606766,
-0.011865735985338688,
-0.13717788457870483,
0.01782447285950184,
0.1434255689382553,
0.014590226113796234,
0.32263195514678955,
-0.3440259099006653,
0.03110567294061184,
-0.10299152880907059,
0.5871093273162842,
0.282710999250412,
0.07530030608177185,
-0.25371429324150085,
-0.36032646894454956,
0.08362867683172226,
-0.02266141213476658,
0.4828483462333679,
-0.40606582164764404,
-0.04973997548222542,
-0.18865478038787842,
-0.16075026988983154,
0.7658986449241638,
-0.3091450333595276,
0.19211243093013763,
-0.07898707687854767,
0.3420913815498352,
0.18502457439899445,
0.4342323839664459,
0.4807641804218292,
-0.4850093424320221,
0.24877263605594635,
0.2912558913230896,
-0.2954336702823639,
0.1294742077589035,
-0.13663335144519806,
0.4241434931755066,
-0.15904617309570312,
-0.1528310626745224,
0.23684507608413696,
0.07769724726676941,
-0.44267234206199646,
-0.20500199496746063,
0.10090891271829605,
1.2624893188476562,
-0.2239835262298584,
-0.5264332890510559,
0.8673520684242249,
0.00870446115732193,
-0.15223412215709686,
-0.5840233564376831,
0.1564776450395584,
0.8405625224113464,
-0.3551594614982605,
-1.250719428062439,
0.007945096120238304,
-0.07993245124816895,
-0.15260516107082367,
0.31565842032432556,
0.4057638645172119,
0.34185436367988586,
-0.16743578016757965,
-0.05348268151283264,
-0.21846941113471985,
0.298511266708374,
0.47734400629997253,
-0.35728222131729126,
0.11866707354784012,
0.057249974459409714,
-0.38555628061294556,
0.40269333124160767,
-0.04539518430829048,
0.4280697703361511,
0.2773416042327881,
-0.296366810798645,
0.353023499250412,
0.13194169104099274,
0.16624248027801514,
0.3801289498806,
-0.5610726475715637,
0.4680834710597992,
-0.2859281003475189,
0.3331732749938965,
-0.8395636677742004,
-0.39619091153144836,
0.02935817278921604,
0.1350538730621338,
0.08736749738454819,
-0.06804392486810684,
0.12358372658491135,
0.2773492634296417,
0.24478383362293243,
-0.5673885345458984,
0.062184277921915054,
-0.21839618682861328,
-0.3260142207145691,
0.04051012545824051,
-0.08795326203107834,
-0.3405884802341461,
-0.13359852135181427,
0.1756199300289154,
0.6744889616966248,
0.5409066081047058,
-0.01177544891834259,
0.5088958144187927,
-0.006722109857946634,
0.018046297132968903,
0.13239583373069763,
0.6433557868003845,
-0.07220648229122162,
-0.17101618647575378,
0.10985387116670609,
-0.13569976389408112,
0.30354607105255127,
-0.2102244794368744,
-0.7631757259368896,
-0.6306059956550598,
-0.45843130350112915,
-0.020865119993686676,
0.30873534083366394,
0.760216474533081,
0.5041926503181458,
-0.19919751584529877,
0.17117902636528015,
0.6805330514907837,
0.06770514696836472,
0.8094663619995117,
0.8071386218070984,
-0.27348119020462036,
-0.07223254442214966,
-0.2581486403942108,
0.02285913936793804,
0.4926190972328186,
-1.1163623332977295,
-0.01840398646891117,
-1.013603925704956,
-0.10085929185152054,
-0.8024477362632751,
0.06612762063741684,
0.3378356099128723,
0.26119568943977356,
0.03747425600886345,
0.31114864349365234,
0.1274736076593399,
-0.4479161500930786,
-0.12467684596776962,
-0.09044583886861801,
0.6241431832313538,
0.490196168422699,
-0.22153373062610626,
-0.20885668694972992,
-0.014186042360961437,
-0.38008707761764526,
0.03897228464484215,
0.10391294956207275,
-0.22231391072273254,
0.16405203938484192,
-0.024747563526034355,
-6.03202486038208,
0.2511853575706482,
-0.4502982497215271,
0.23299722373485565,
0.008128291927278042,
0.1521800011396408,
0.8637798428535461,
-0.1192551851272583,
0.08180521428585052,
0.18371285498142242,
0.8499356508255005,
0.5023497939109802,
0.31379520893096924,
-0.33466532826423645,
0.05356031656265259,
0.3164813220500946,
0.200291708111763,
-0.08938542008399963,
0.02880510874092579,
0.6480048894882202,
-0.1843097060918808,
-0.428778737783432,
0.4729672968387604,
0.23564670979976654,
0.4036670923233032,
0.6496979594230652,
-0.3704974353313446,
-0.4528525769710541,
0.09282614290714264,
0.2694152295589447,
-0.37835875153541565,
-0.5185697674751282,
0.02845236286520958,
-0.5394975543022156,
-0.09011873602867126,
-0.14195789396762848,
0.10378674417734146,
-0.409729927778244,
-0.2461041808128357,
-0.20306292176246643,
-0.058645233511924744,
0.04764547199010849,
0.4553714990615845,
-0.45459413528442383,
0.1794976443052292,
0.11233571916818619,
-0.09210539609193802,
-0.4684500992298126,
-0.10427766293287277,
0.45843443274497986,
0.28343501687049866,
0.5075265169143677,
0.11626636981964111,
0.3743625581264496,
0.32530930638313293,
-0.4229477345943451,
0.09319702535867691,
0.37492188811302185,
-0.037242159247398376,
-0.3618146777153015,
0.323382169008255,
-0.18004348874092102,
-0.2035702019929886,
0.2827318012714386,
-0.010012290440499783,
-0.07950764894485474,
-0.5285415649414062,
-0.32972362637519836,
0.27828675508499146,
0.1438768208026886,
-0.35224583745002747,
0.10847553610801697,
-0.030920717865228653,
-0.7330494523048401,
0.04708464816212654,
-0.45448559522628784,
-0.16795693337917328,
-0.2966266870498657,
-0.25783273577690125,
-0.3859778940677643,
-0.39977726340293884,
0.2514694631099701,
-0.3607870936393738,
0.0008678510785102844,
-0.20677879452705383,
-0.7709953784942627,
-0.1326759308576584,
0.35471826791763306,
-0.46395617723464966,
-0.3731507360935211,
0.3299983739852905,
-0.4700016677379608,
0.31283092498779297,
0.0314335934817791,
0.21213360130786896,
0.40715548396110535,
0.21391791105270386,
0.31557586789131165,
0.16584686934947968,
0.08135472238063812,
1.357708215713501,
0.07893160730600357,
-0.5761765837669373,
-1.1678860187530518,
-0.4112093448638916,
-0.4506869316101074,
0.08065761625766754,
0.5984469056129456,
0.8468292355537415,
-0.29022327065467834,
-0.3051111102104187,
-0.216487318277359,
-0.11477412283420563,
-0.17885629832744598,
0.4100382328033447,
0.3192107379436493,
0.15047587454319,
0.3135873079299927,
0.41424959897994995,
-0.11726932972669601,
0.3111358880996704,
0.8470503687858582,
-0.539475679397583,
0.36677879095077515,
0.47204992175102234,
-0.2378210425376892,
-0.01766529679298401,
-0.020541148260235786,
-0.32527828216552734,
-0.4432535767555237,
-0.048967018723487854,
0.16295477747917175,
0.3511286675930023,
0.07249735295772552,
0.6972902417182922,
-0.024666206911206245,
-0.11908161640167236,
-0.03819767013192177,
-0.12253712862730026,
-0.3566916882991791,
-0.35736095905303955,
-0.037554819136857986,
-0.12178941071033478,
0.1996871531009674,
-0.13275614380836487,
0.15219837427139282,
0.19969609379768372,
-0.14307169616222382,
-0.11909230798482895,
-0.10807682573795319,
-0.05800015851855278,
-0.036626044660806656,
0.029757998883724213,
0.5523940324783325,
-0.3575490713119507,
-0.4367252290248871,
0.808663010597229,
0.04767380282282829,
0.0012764137936756015,
-0.6254453659057617,
0.17448963224887848,
0.022020095959305763,
-0.4563664197921753,
0.07599438726902008,
0.3128489851951599,
-0.03154630959033966,
-0.18676623702049255,
-0.3482092320919037,
0.1278960257768631,
0.5775389671325684,
0.28350207209587097,
-0.3849281966686249,
0.1761568784713745,
0.2920733094215393,
-0.26467931270599365,
-0.029114406555891037,
-0.14461825788021088,
-0.5995723009109497,
-0.21137458086013794,
0.6094167232513428,
0.38601720333099365,
-0.4958425760269165,
-0.8295886516571045,
0.17838500440120697,
0.19764700531959534,
0.2025805115699768,
0.3967937231063843,
-0.30611652135849,
0.1822834461927414,
-0.04582306742668152,
0.1758642941713333,
-0.12635056674480438,
-0.4329298436641693,
0.2901562750339508,
-0.42362159490585327,
-0.18641911447048187,
-0.5164117813110352,
0.17202869057655334,
-0.4448179006576538,
0.269787460565567,
0.417575865983963,
0.4886988699436188,
-0.7090215682983398,
-0.1512405276298523,
-0.30157986283302307,
0.06870593875646591,
0.12459065765142441,
0.19533710181713104,
0.20223087072372437,
0.1917039453983307,
-0.047902997583150864,
0.38796231150627136,
-0.2077682763338089,
0.3676806390285492,
0.02953091263771057,
0.27379804849624634,
-0.003587737213820219,
-0.5050434470176697,
0.04273393750190735,
0.22705282270908356,
-0.4648863673210144,
-0.14451314508914948,
0.06906484067440033,
-0.4860858619213104,
-0.1511145532131195,
0.8259032964706421,
0.1094130128622055,
-0.8014586567878723,
-0.3418727517127991,
-0.2501644194126129,
-0.3926562964916229,
-0.31087106466293335,
0.25728681683540344,
0.06006699055433273,
-0.10347823053598404,
0.19805583357810974,
0.21054615080356598,
-0.04569956287741661,
0.1859096884727478,
0.38617274165153503,
0.14403574168682098,
0.5638702511787415,
-0.33706408739089966,
-0.12870892882347107,
-0.06412936002016068,
0.019116127863526344,
-0.06488341838121414,
-0.6425132751464844,
-0.011918948963284492,
-0.22569023072719574,
-0.4416217505931854,
-0.25406551361083984,
0.07384646683931351,
0.2822556495666504,
0.24980930984020233,
0.28162458539009094,
-0.1846594214439392,
0.1352664679288864,
-0.4231165647506714,
-0.07143324613571167,
-0.1798546463251114,
0.4406631886959076,
-0.7992916703224182,
0.29559385776519775,
0.34914281964302063,
-0.5092306733131409,
-0.45413947105407715,
0.18363651633262634,
-0.24261081218719482,
-0.17812469601631165,
-0.03173059970140457,
0.6209204196929932,
0.7807047963142395,
0.4067155420780182,
-0.04279758781194687,
0.17050021886825562,
-0.003220688086003065,
-0.06694529950618744,
-0.2641955614089966,
0.2558010518550873,
-0.5360666513442993,
-0.28864842653274536,
-0.14174684882164001,
-0.12184354662895203,
0.31311148405075073,
-0.366703063249588,
-0.14202678203582764,
-0.3456347584724426,
-0.025015952065587044,
-0.7366381287574768,
0.31862449645996094,
-0.10567716509103775,
0.034194234758615494,
-0.2633189857006073,
-0.10342949628829956,
0.004917144309729338,
0.687956690788269,
0.14233849942684174,
-0.06852781772613525,
0.14758151769638062,
-0.9781959652900696,
0.685876190662384,
0.11260908097028732,
-0.6852439045906067,
0.2964417040348053,
-0.051272518932819366,
0.3816370964050293,
0.30712199211120605,
-0.5158953666687012,
-0.17938785254955292,
0.32659846544265747,
-0.6806118488311768,
-0.0005714849103242159,
0.3591538965702057,
-0.38532039523124695,
0.283596009016037,
0.4103159010410309,
-0.42052319645881653,
-0.14847174286842346,
-0.15888752043247223,
0.04884706810116768,
0.3915562331676483,
-0.5828983783721924,
0.14751926064491272,
0.006250059697777033,
-0.009144498035311699,
-0.27438390254974365,
0.1717662811279297,
0.08475764095783234,
0.3946702778339386,
0.13351301848888397,
0.25984737277030945,
-0.4056941270828247,
0.2129542976617813,
-0.21008649468421936,
0.2211856245994568,
0.1394239068031311,
-0.5319984555244446,
-0.2838112711906433,
0.6371423602104187,
0.9256104230880737,
0.11511329561471939,
0.007157486863434315,
-0.16702888906002045,
-0.4793238341808319,
0.16499295830726624,
0.0696847066283226,
-0.30999666452407837,
0.5483670830726624,
0.12339470535516739,
0.8048445582389832,
-0.11452373117208481,
-0.07091428339481354,
0.5806087255477905,
-0.0546492300927639,
-0.4967195391654968,
0.2732899487018585,
-0.39644238352775574,
-0.7327123880386353,
-0.6923609972000122,
0.07449837028980255,
0.36353757977485657,
0.37903138995170593,
0.23279821872711182,
0.29072314500808716,
-0.05975694581866264,
0.335653156042099,
-0.0069699534215033054,
-0.31964653730392456,
-0.24044065177440643,
0.07145444303750992,
-0.24992386996746063,
0.000010879585715883877,
0.009282744489610195,
0.406783789396286,
0.28992775082588196,
0.6079267263412476,
-0.029848618432879448,
0.08347725123167038,
0.3235734701156616,
-0.5505715012550354,
-0.03890691697597504,
-0.16743077337741852,
-0.380710631608963,
-0.11149043589830399,
0.5720876455307007,
-0.5928103923797607,
0.08153774589300156,
-0.2275172919034958,
0.2557919919490814,
0.09775339066982269,
-0.7450013756752014,
-0.1512308418750763,
0.4196554720401764,
0.40418344736099243,
-0.41802161931991577,
0.27238377928733826,
0.6353046298027039,
-0.30741971731185913,
-0.19962859153747559,
0.21439968049526215,
-0.024697085842490196,
-0.5191394686698914,
0.26635298132896423,
-0.20021377503871918,
0.543493390083313,
-0.792714536190033,
-0.144224613904953,
0.032535161823034286,
0.14196094870567322,
0.29574957489967346,
0.0044234092347323895,
-0.3819211721420288,
-0.04193798080086708,
0.16802047193050385,
0.33777952194213867,
0.551544725894928,
-0.5910502076148987,
0.165108323097229,
-0.740568220615387,
0.38791829347610474,
-0.18375644087791443,
-0.2725529074668884,
0.19563211500644684,
0.13982394337654114,
-0.05747997760772705,
0.1673707664012909,
0.3489969074726105,
-0.5635910630226135,
0.9486709833145142,
-0.34363019466400146,
0.16800540685653687,
0.047072455286979675,
-0.14181019365787506,
0.16406390070915222,
-0.7064961194992065,
0.5420593023300171,
0.3833516836166382,
0.05226534977555275,
-0.3355294167995453,
0.33975934982299805,
0.03651310130953789,
-0.2413649708032608,
-0.2089984267950058,
0.44444820284843445,
-0.08339890837669373,
-0.1304854303598404,
-0.47461608052253723,
-0.27928903698921204,
0.1443880945444107,
-0.2749486267566681,
-0.0703861266374588,
-0.37832748889923096,
0.1868869960308075,
-0.2492208033800125,
-0.09398294985294342,
0.20703397691249847,
0.23580236732959747,
0.6175172924995422,
-0.1473166048526764
] |
Enveloped viruses use specialized protein machinery to fuse the viral membrane with that of the host cell during cell invasion. In influenza virus, hundreds of copies of the haemagglutinin (HA) fusion glycoprotein project from the virus surface. Despite intensive study of HA and its fusion activity, the protein's modus operandi in manipulating viral and target membranes to catalyse their fusion is poorly understood. Here, the three-dimensional architecture of influenza virus–liposome complexes at pH 5.5 was investigated by electron cryo-tomography. Tomographic reconstructions show that early stages of membrane remodeling take place in a target membrane-centric manner, progressing from punctate dimples, to the formation of a pinched liposomal funnel that may impinge on the apparently unperturbed viral envelope. The results suggest that the M1 matrix layer serves as an endoskeleton for the virus and a foundation for HA during membrane fusion. Fluorescence spectroscopy monitoring fusion between liposomes and virions shows that leakage of liposome contents takes place more rapidly than lipid mixing at pH 5.5. The relation of ‘leaky' fusion to the observed prefusion structures is discussed. | [
-0.017417604103684425,
0.00951431505382061,
0.007619165815412998,
0.01687479205429554,
-0.008359601721167564,
-0.01588091067969799,
0.010665930807590485,
-0.010923397727310658,
-0.014940513297915459,
-0.011660132557153702,
-0.010051533579826355,
0.008109115064144135,
-0.01017317920923233,
0.010232237167656422,
0.015151132829487324,
-0.026297347620129585,
-0.013994533568620682,
-0.008190065622329712,
0.006310385651886463,
-0.0035545947030186653,
0.0059176660142838955,
0.006847552955150604,
0.010858261026442051,
0.01083914004266262,
0.0044654374942183495,
-0.0002388223074376583,
0.00520246010273695,
-0.02374402806162834,
-0.011814041063189507,
-0.019808882847428322,
0.017185084521770477,
-0.009167889133095741,
0.01608964055776596,
0.011397759430110455,
0.006548292934894562,
0.009629163891077042,
-0.0030435705557465553,
0.03174431994557381,
0.008932691067457199,
-0.002843625843524933,
0.0042888568714261055,
-0.010026644915342331,
-0.003186369314789772,
0.012594032101333141,
-0.004956568591296673,
0.0323420912027359,
-0.0006246653501875699,
0.000974329886958003,
0.0006515388377010822,
0.0030503664165735245,
-0.011256460100412369,
-0.014665362425148487,
0.0005832929164171219,
0.0029869787395000458,
-0.0063482653349637985,
0.004888834897428751,
0.018448520451784134,
-0.018879404291510582,
-0.040236130356788635,
0.03069387376308441,
-0.016725126653909683,
-0.00982893817126751,
0.007360457442700863,
-0.01594213768839836,
-0.0017330781556665897,
-0.06679517030715942,
-0.0023758315946906805,
0.004497217945754528,
0.015179619193077087,
0.0058798398822546005,
0.022457551211118698,
0.010432234965264797,
-0.014931470155715942,
0.02920519933104515,
-0.04099005460739136,
-0.008420402184128761,
-0.020268026739358902,
-0.0019286422757431865,
-0.008194172754883766,
0.01449876744300127,
-0.03276461735367775,
0.013869511894881725,
-0.003112881211563945,
0.0007835942087695003,
0.017508070915937424,
0.025299210101366043,
-0.019906852394342422,
-0.005807038862258196,
0.012514134868979454,
-0.020680749788880348,
0.026992347091436386,
0.00600372813642025,
-0.02710043080151081,
0.012696045450866222,
-0.006586756557226181,
0.01565096713602543,
-0.028948402032256126,
-0.018783722072839737,
-0.013755067251622677,
-0.038138747215270996,
-0.008632894605398178,
0.01762573979794979,
0.011551488190889359,
-0.006055890582501888,
0.008723503910005093,
0.008018691092729568,
0.012601559981703758,
0.00984007865190506,
0.03995504602789879,
0.00839688628911972,
0.007211873773485422,
0.01252739131450653,
0.019745875149965286,
0.02668154053390026,
0.005693311803042889,
0.019956909120082855,
-0.0037269259337335825,
0.018838420510292053,
0.011664601042866707,
0.004822924733161926,
0.02317868173122406,
0.008263792842626572,
0.009856000542640686,
-0.0037951283156871796,
0.00735115772113204,
-0.03407784551382065,
-0.009947547689080238,
-0.027892502024769783,
0.021384935826063156,
-0.002390312496572733,
-0.00919839832931757,
-0.0012505454942584038,
-0.009475157596170902,
-0.0237031988799572,
-0.01854252628982067,
-0.0014218497090041637,
-0.004655914381146431,
-0.010151468217372894,
-0.002558039501309395,
-0.009269611909985542,
-0.0059717996045947075,
0.006322707049548626,
0.00481134420260787,
0.02279484272003174,
0.026080166921019554,
0.006120506674051285,
-0.001132556120865047,
0.0177871435880661,
0.043145470321178436,
-0.005420237313956022,
0.009278682060539722,
-0.007506243884563446,
-0.015669729560613632,
-0.013038545846939087,
-0.009060535579919815,
0.0029471484012901783,
0.005082691088318825,
-0.015640733763575554,
-0.013729439117014408,
-0.015848997980356216,
-0.00453899335116148,
-0.0433468371629715,
0.008260603994131088,
0.007554648444056511,
-0.027893366292119026,
-0.004483405500650406,
0.03350416570901871,
-0.031058605760335922,
-0.010184455662965775,
0.0062706368044018745,
-0.005346675869077444,
0.01377061102539301,
0.023832259699702263,
0.012245358899235725,
-0.011483164504170418,
0.01455568615347147,
-0.0027888014446944,
0.009083062410354614,
-0.022836102172732353,
0.06671144813299179,
-0.0010916911996901035,
-0.0011158431880176067,
-0.002783409086987376,
0.011471547186374664,
-0.0038513988256454468,
-0.010402848944067955,
0.00006346125155687332,
-0.017411891371011734,
0.006546773947775364,
-0.035202011466026306,
-0.019429925829172134,
-0.010934412479400635,
-0.007701430935412645,
-0.024094069376587868,
-0.004829182289540768,
0.0038339735474437475,
0.004322820343077183,
0.009084023535251617,
0.006444619037210941,
-0.022832263261079788,
0.01095916610211134,
0.00032653985545039177,
0.029430445283651352,
0.02462976984679699,
-0.024283263832330704,
0.000023656990379095078,
0.0049873157404363155,
0.010360847227275372,
-0.007771875709295273,
0.0021984963677823544,
0.02376161329448223,
0.001412686426192522,
-0.01192993950098753,
-0.014411736279726028,
0.006311213597655296,
-0.001439027488231659,
0.019258122891187668,
0.016032643616199493,
0.012070972472429276,
-0.011461958289146423,
0.0007638823008164763,
-0.00957814697176218,
-0.013030759058892727,
-0.013069415464997292,
0.03242044895887375,
-0.005787027534097433,
-0.008017824031412601,
0.015006041154265404,
-0.03309087082743645,
0.015077771618962288,
-0.00571412593126297,
-0.036718063056468964,
-0.011840508319437504,
0.007289527449756861,
0.01661364734172821,
-0.023000629618763924,
0.014491396024823189,
-0.03151978552341461,
0.004467406310141087,
-0.01176590844988823,
-0.001022118958644569,
0.022396640852093697,
0.029649531468749046,
-0.021246572956442833,
-0.004581807646900415,
0.0007476704195141792,
-0.014326190575957298,
0.010263292118906975,
-0.006588820833712816,
-0.04590896889567375,
0.00981823354959488,
0.026327766478061676,
-0.0008924282155930996,
-0.04904070869088173,
0.023218080401420593,
0.010899871587753296,
0.033381976187229156,
0.01386948861181736,
0.023346031084656715,
-0.0073280055075883865,
-0.002139415591955185,
0.00168586743529886,
-0.008135298267006874,
0.004719486925750971,
-0.014506909996271133,
0.0343814343214035,
-0.008066312409937382,
-0.004393788054585457,
-0.021644987165927887,
0.019738873466849327,
0.0068621258251369,
-0.004984334111213684,
-0.003824664745479822,
-0.08136015385389328,
-0.018170848488807678,
0.021799037232995033,
0.004552249796688557,
0.0069069224409759045,
-0.0005404020193964243,
-0.0031477389857172966,
-0.012054349295794964,
-0.005353634245693684,
0.012231236323714256,
0.009417710825800896,
0.012010142207145691,
-0.009136817418038845,
0.000740882009267807,
-0.011150519363582134,
-0.00997249037027359,
0.010731921531260014,
0.008800613693892956,
-0.01572604849934578,
-0.010677970945835114,
-0.013254616409540176,
-0.0014641089364886284,
0.01522710733115673,
0.0025528427213430405,
-0.02195218950510025,
-0.006943281274288893,
0.020657695829868317,
0.0010145986452698708,
-0.0074741290882229805,
0.010531106032431126,
-0.004943937994539738,
-0.008826068602502346,
0.04497341811656952,
-0.027868516743183136,
0.04614945128560066,
0.02305460348725319,
0.011903122067451477,
0.005940479226410389,
-0.01018861960619688,
-0.018143268302083015,
-0.016039228066802025,
0.008257253095507622,
0.00547184981405735,
0.01348842028528452,
0.024996209889650345,
-0.00048753037117421627,
0.002903602784499526,
-0.0017701606266200542,
0.025289759039878845,
0.003817101242020726,
-0.010362407192587852,
0.0036291966680437326,
0.010214866138994694,
0.020620625466108322,
-0.01800723746418953,
0.022108983248472214,
-0.010227935388684273,
0.022014228627085686,
-0.01592831127345562,
-0.004634549375623465,
-0.019358130171895027,
0.031402479857206345,
-0.007333075162023306,
-0.0014416291378438473,
-0.020989082753658295,
0.008322549052536488,
0.014803529717028141,
0.009970499202609062,
-0.014815466478466988,
0.01250246912240982,
0.008173867128789425,
0.0035379971377551556,
0.004946198780089617,
-0.0020071123726665974,
-0.007144272793084383,
-0.0059548416174948215,
-0.012590128928422928,
-0.015893634408712387,
-0.007551747374236584,
-0.04160134866833687,
-0.03499232232570648,
0.014161160215735435,
-0.02325734868645668,
-0.014881789684295654,
-0.020374394953250885,
-0.04169762507081032,
0.008191360160708427,
-0.006533836014568806,
0.01021257322281599,
-0.019423846155405045,
-0.0009731599129736423,
-0.003101679030805826,
-0.04980476573109627,
0.010466046631336212,
-0.024499040096998215,
-0.01635441556572914,
0.007012041285634041,
0.023130623623728752,
0.006546998396515846,
0.009884748607873917,
-0.028157144784927368,
-0.0025101331993937492,
0.015120727941393852,
-0.006967219524085522,
-0.028300262987613678,
0.020218532532453537,
-0.00009787461021915078,
-0.024914128705859184,
-0.003186347894370556,
-0.005868064239621162,
-0.0007161973044276237,
0.027003582566976547,
-0.014742602594196796,
-0.028027813881635666,
0.011595498770475388,
0.009497841820120811,
-0.013393912464380264,
-0.026386531069874763,
0.07187537848949432,
-0.00888110976666212,
0.007210469804704189,
-0.013829313218593597,
0.03902840614318848,
-0.022733360528945923,
0.02515534497797489,
0.005713155493140221,
0.0010979888029396534,
0.0010581932729110122,
0.01158600952476263,
-0.03042663261294365,
0.005830679554492235,
-0.027752624824643135,
0.008639383129775524,
-0.01023816131055355,
-0.003919701091945171,
-0.05296923220157623,
0.009128288365900517,
0.026301251724362373,
0.003654919099062681,
-0.010556773282587528,
-0.0000208364799618721,
-0.01748083345592022,
0.0066905333660542965,
0.00714160967618227,
0.021337317302823067,
-0.013536064885556698,
-0.008708944544196129,
0.016078656539320946,
0.010048512369394302,
-0.018419288098812103,
-0.003920732531696558,
0.016034509986639023,
0.03344522416591644,
-0.005760827101767063,
0.005590634420514107,
0.0028925458900630474,
-0.010137754492461681,
-0.005717812571674585,
-0.010099099949002266,
-0.014671205542981625,
-0.011072789318859577,
0.020882729440927505,
-0.01408843882381916,
-0.015649165958166122,
-0.011563391424715519,
-0.008908875286579132,
-0.014663743786513805,
-0.014670578762888908,
-0.008054973557591438,
-0.0013558012433350086,
0.007995232939720154,
0.0166923888027668,
0.02208888903260231,
0.00008544186130166054,
0.010444769635796547,
-0.006413093768060207,
0.007750228047370911,
-0.00787721574306488,
-0.035836201161146164,
-0.002162972465157509,
0.016105003654956818,
-0.02150285243988037,
0.02273290418088436,
-0.015641260892152786,
0.004355150740593672,
0.013358044438064098,
-0.009530833922326565,
0.0073775555938482285,
0.021789342164993286,
-0.016428062692284584,
-0.013104471378028393,
-0.016871245577931404,
-0.01076521072536707,
-0.023877067491412163,
-0.008769920095801353,
-0.014251158572733402,
0.013078185729682446,
0.012847122736275196,
0.023568861186504364,
-0.009265861473977566,
0.029521772637963295,
-0.00929422676563263,
-0.027608267962932587,
0.0065833805128932,
-0.024103010073304176,
-0.07402047514915466,
-0.015623422339558601,
-0.011828010901808739,
-0.004150593653321266,
0.028016190975904465,
0.0042634992860257626,
-0.011781584471464157,
-0.028641145676374435,
-0.02159305289387703,
-0.006336614489555359,
0.037154003977775574,
0.023676101118326187,
0.0325990691781044,
0.014097684994339943,
0.012048562988638878,
-0.016467981040477753,
-0.02757851406931877,
-0.0002674137940630317,
-0.023088067770004272,
-0.004933138377964497,
-0.01619967631995678,
0.022021614015102386,
-0.03712885081768036,
-0.001780614722520113,
0.002421434037387371,
-0.08075031638145447,
-0.01727989874780178,
-0.009802429936826229,
-0.03567470237612724,
0.011294757016003132,
-0.030787106603384018,
-0.0344671905040741,
-0.004920759703963995,
-0.038047440350055695,
-0.01633075252175331,
0.003270748071372509,
-0.006106343120336533,
0.009497791528701782,
-0.01015017181634903,
0.0063134911470115185,
-0.00815269909799099,
-0.005332419648766518,
0.022209255024790764,
-0.00200265203602612,
0.010544946417212486,
0.018968699499964714,
0.0112905353307724,
-0.015237491577863693,
0.006528803147375584,
-0.009943678975105286,
-0.000038321129977703094,
-0.00589686818420887,
0.01056358590722084,
0.0048133609816432,
-0.0019291357602924109,
-0.025488853454589844,
0.02660759538412094,
-0.009366086684167385,
-0.03111759014427662,
0.021413292735815048,
-0.010875912383198738,
0.016654934734106064,
0.0020633358508348465,
0.008301857858896255,
-0.006075258366763592,
-0.010877983644604683,
0.006652442272752523,
0.01600155606865883,
0.011241722851991653,
0.008980711922049522,
-0.003431891091167927,
0.006865121424198151,
-0.0051401713863015175,
0.023139839991927147,
-0.007749718148261309,
0.010564886964857578,
-0.05794009938836098,
-0.01778258942067623,
0.0013424737844616175,
-0.02522476390004158,
-0.0016934380400925875,
0.002437783405184746,
0.016836434602737427,
0.007875392213463783,
0.005708635784685612,
-0.008013223297894001,
-0.009862135164439678,
0.014766557142138481,
0.07166628539562225,
-0.00302197877317667,
0.009096374735236168,
-0.013823595829308033,
-0.006393652409315109,
0.0003596798051148653,
0.01961340568959713,
0.0007455877494066954,
-0.00023437105119228363,
-0.01874670758843422,
0.021579749882221222,
-0.009416204877197742,
-0.015095122158527374,
0.0101042240858078,
-0.010619903914630413,
-0.009146444499492645,
-0.014643097296357155,
-0.004183799494057894,
-0.05517539009451866,
0.039454296231269836,
-0.014624329283833504,
-0.025428470224142075,
-0.018972432240843773,
0.005119792185723782,
0.035884078592061996,
0.00878343265503645,
-0.03330262005329132,
0.013133593834936619,
-0.030775904655456543,
-0.00777804758399725,
-0.014332903549075127,
-0.007523389533162117,
-0.003327556885778904,
-0.0033663082867860794,
0.017610643059015274,
-0.012830236926674843,
-0.0012693661265075207,
0.005339841358363628,
-0.013781054876744747,
0.022364377975463867,
0.004779195412993431,
-0.0035129308234900236,
-0.00984229240566492,
-0.005499580409377813,
0.009667365811765194,
-0.022688735276460648,
0.01182577759027481,
0.004701642785221338,
0.013631624169647694,
0.016063455492258072,
0.015408201143145561,
-0.002148666186258197,
0.0339222177863121,
-0.004842513240873814,
0.018468094989657402,
0.009191315621137619,
-0.020032178610563278,
0.014289387501776218,
-0.010658087208867073,
0.011506006121635437,
-0.00016072543803602457,
-0.01650822162628174,
-0.0031072748824954033,
-0.01953185349702835,
0.016826720908284187,
-0.011579765006899834,
0.02935410663485527,
-0.012634800747036934,
-0.009709388017654419,
0.01793459802865982,
0.003595982911065221,
0.02431153878569603,
0.007356241345405579,
-0.001027425518259406,
0.01557621918618679,
0.014130106195807457,
0.00693324813619256,
-0.003956901840865612,
0.024995945394039154,
0.015082660131156445,
-0.010014193132519722,
-0.044582806527614594,
0.0001440737396478653,
0.03645773604512215,
-0.0016558676725253463,
0.00637736264616251,
-0.005396321881562471,
-0.001744043081998825,
-0.0017842177767306566,
0.012135879136621952,
0.0028524294029921293,
-0.010136342607438564,
0.0024243956431746483,
0.011266768909990788,
0.00738264387473464,
0.033789072185754776,
0.006994651164859533,
-0.0010630020406097174,
0.028028259053826332,
0.0062387436628341675,
0.0023610186763107777,
-0.036937613040208817,
0.0005122577422298491,
0.004639883991330862,
-0.010113786906003952,
-0.005319700576364994,
0.024737954139709473,
-0.00982687994837761,
0.005628310143947601,
-0.005681582726538181,
0.021239593625068665,
0.026214897632598877,
0.03285137563943863,
0.011344216763973236,
-0.016799937933683395,
0.03620177134871483,
-0.01230243407189846,
0.03173021972179413,
-0.017180411145091057,
-0.007148461416363716,
-0.011640813201665878,
0.006514986976981163,
-0.011714288964867592,
0.0073273819871246815,
0.008428726345300674,
-0.01548315491527319,
-0.010542384348809719,
0.006579423323273659,
-0.003286495339125395,
0.01286633312702179,
0.015647554770112038,
-0.02507619373500347,
0.0018165681976824999,
0.017991412431001663,
0.020575499162077904,
0.004858714062720537,
0.013381325639784336,
0.00342511641792953,
-0.003913612104952335,
-0.02393566444516182,
-0.017892638221383095,
-0.02039809338748455,
0.0008070005569607019,
-0.023778732866048813,
0.0063802096992731094,
-0.0012764136772602797,
0.012545961886644363,
0.002623580861836672,
0.006710782181471586,
0.010724017396569252,
0.019172850996255875,
0.01215371023863554,
0.0023520789109170437,
-0.009788787923753262,
0.005526779219508171,
0.01912079006433487,
0.001817494397982955,
-0.05359442159533501,
-0.0009800144471228123,
0.011504372581839561,
0.018488695845007896,
-0.0028412528336048126,
0.03612864390015602,
0.008209073916077614,
0.005093694664537907,
0.031150583177804947,
0.004583221860229969,
0.004227199126034975,
0.0010484429076313972,
0.02435660921037197,
0.019825557246804237,
-0.02410981059074402,
0.029473017901182175,
0.009655339643359184,
-0.024116255342960358,
-0.016934499144554138,
-0.029114384204149246,
0.0045236703008413315,
0.0015851120697334409,
0.003641633316874504,
0.010538841597735882,
-0.019204672425985336,
0.00844532623887062,
-0.0011057427618652582,
0.0031701058614999056,
-0.014520025812089443,
-0.020204000174999237,
0.028459884226322174,
0.021857447922229767,
-0.003417434636503458,
-0.02283141203224659,
0.0027090138755738735,
-0.0029670475050807,
0.0215957909822464,
-0.009370081126689911,
-0.0007812073454260826,
0.002491207327693701,
-0.02063087932765484,
0.005403743125498295,
0.02688901126384735,
-0.0009957368019968271,
-0.01166914775967598
] | [
-0.09238599985837936,
0.24625778198242188,
0.2226674109697342,
-0.2540019452571869,
-0.04212873801589012,
-0.1881929636001587,
0.051225703209638596,
-0.01854299008846283,
-0.34062522649765015,
-0.790905773639679,
0.30757907032966614,
-0.3254680633544922,
-0.8004836440086365,
0.5088984370231628,
0.17363794147968292,
0.4963550567626953,
0.1916622519493103,
0.4373103976249695,
-0.5307777523994446,
-0.19286209344863892,
-0.341024786233902,
-0.06428764015436172,
0.3723944127559662,
0.24252818524837494,
0.2028086632490158,
-0.5061646699905396,
0.4124849736690521,
-0.27161452174186707,
0.8629125356674194,
-0.3103969097137451,
-0.09383256733417511,
0.5324620008468628,
0.0617552176117897,
-0.12755633890628815,
0.013640660792589188,
-0.4592665135860443,
-0.6032695770263672,
0.5697863101959229,
0.061930328607559204,
-0.28037482500076294,
-0.3562079668045044,
-0.3750171959400177,
-0.1004640981554985,
0.13126356899738312,
0.021316787227988243,
-0.7631338238716125,
-1.0042688846588135,
0.9758476614952087,
-0.5367528200149536,
0.2266491800546646,
0.13770712912082672,
-0.018506791442632675,
0.2703128457069397,
0.08964718133211136,
0.16965195536613464,
0.16422636806964874,
-0.733467698097229,
0.2929794192314148,
0.7130967378616333,
-0.3640168011188507,
0.19234514236450195,
-0.24115268886089325,
-0.1911914050579071,
0.2339431345462799,
-0.1407873034477234,
0.8159750699996948,
0.14378467202186584,
-0.19466911256313324,
-0.5388888716697693,
-0.4491261839866638,
0.1973203867673874,
-0.7167770862579346,
-0.034596625715494156,
0.22762943804264069,
0.24080240726470947,
-0.3081495463848114,
-0.7311936616897583,
-0.2911568582057953,
0.149110808968544,
0.20157672464847565,
-0.563977062702179,
0.25448310375213623,
-0.19433385133743286,
-0.19623461365699768,
0.6106458306312561,
0.14745961129665375,
-0.42160671949386597,
0.7803255915641785,
-0.2875288128852844,
0.003792970208451152,
0.11342018097639084,
0.17177163064479828,
0.6289212107658386,
0.4489721357822418,
0.09479338675737381,
0.18398000299930573,
-0.08535559475421906,
0.26093682646751404,
0.09517605602741241,
0.23608236014842987,
-0.17944307625293732,
0.17898878455162048,
0.087111696600914,
-0.6153321266174316,
-0.41926413774490356,
0.18400682508945465,
-0.36180591583251953,
-0.6790590882301331,
-0.4720372259616852,
0.0125191118568182,
-0.46567302942276,
-0.5536278486251831,
-0.7027045488357544,
-0.4059154987335205,
-0.5058775544166565,
-0.07912544906139374,
0.4620630741119385,
-0.5085393190383911,
-0.028974095359444618,
-0.1372275948524475,
-0.4099176228046417,
1.452304482460022,
0.0060742516070604324,
0.6294106245040894,
0.08724062144756317,
-0.4196421205997467,
0.0510425940155983,
0.0700819343328476,
-0.3845198154449463,
0.8942642211914062,
0.10248196870088577,
0.9263843297958374,
-0.30078208446502686,
0.3446660041809082,
0.24488992989063263,
-0.10094952583312988,
-0.2800308167934418,
0.7495334148406982,
0.4151807427406311,
-0.2941461205482483,
-0.755231499671936,
-0.4485078454017639,
-0.027272675186395645,
0.15060876309871674,
-0.4671228528022766,
-0.47319042682647705,
-0.5548811554908752,
-0.39100614190101624,
-0.26904404163360596,
-0.5868638753890991,
-0.252138614654541,
-0.5987241864204407,
-0.52015620470047,
0.14533062279224396,
0.18311919271945953,
0.2518828511238098,
0.24455982446670532,
0.4269653558731079,
0.2674890458583832,
0.24274563789367676,
0.3949463367462158,
-0.1312030702829361,
-0.48167452216148376,
-0.32830125093460083,
0.12916480004787445,
0.22346438467502594,
0.6772038340568542,
0.5034199357032776,
0.061872854828834534,
-0.18607838451862335,
-0.05715078115463257,
-0.48076704144477844,
0.09902071207761765,
-0.2017398327589035,
-0.12001604586839676,
-0.40758180618286133,
0.4113968312740326,
-0.17868420481681824,
0.08617760241031647,
0.09890788048505783,
-0.7108174562454224,
-0.10871190577745438,
-0.1807403862476349,
-0.32096391916275024,
0.6047762632369995,
0.22177202999591827,
-0.12492457032203674,
-0.07314759492874146,
-0.32912155985832214,
-0.08666631579399109,
-0.08219482749700546,
-0.06335627287626266,
0.12084632366895676,
-0.3987694978713989,
1.2531211376190186,
-0.2621673345565796,
-0.3269784152507782,
1.4652155637741089,
0.3443215787410736,
-0.24190302193164825,
-0.3521813750267029,
0.20010164380073547,
0.5172030329704285,
-0.6112434267997742,
-0.26625877618789673,
0.03089560754597187,
0.2147439420223236,
-0.09434596449136734,
-0.0910327136516571,
-0.16266033053398132,
0.6550723314285278,
-0.5398359894752502,
-0.07590872794389725,
-0.5147387385368347,
0.5143876671791077,
-0.06210843846201897,
-0.47444847226142883,
0.07359445840120316,
-0.2931194603443146,
0.2649562656879425,
0.9296735525131226,
-0.8936744332313538,
0.3560415804386139,
0.7649139165878296,
-0.3117687404155731,
0.828363835811615,
0.686527669429779,
-0.054563701152801514,
0.7490842342376709,
-0.15576712787151337,
0.4924672842025757,
-0.8750596642494202,
0.5440367460250854,
-0.33625438809394836,
-0.5176920890808105,
-0.0959417074918747,
0.34728264808654785,
0.20105807483196259,
0.32120534777641296,
-0.17420706152915955,
0.354945570230484,
0.6844605803489685,
-0.6478606462478638,
-0.14712542295455933,
0.2766907513141632,
-0.6973150372505188,
-0.08848019689321518,
-0.35342147946357727,
-0.5428447723388672,
0.32862231135368347,
-0.16153325140476227,
0.3161827325820923,
0.31563445925712585,
-0.6045193672180176,
0.6213688254356384,
0.047569889575242996,
-0.09429667145013809,
-0.10499029606580734,
0.41099417209625244,
-0.09502829611301422,
-0.2380300909280777,
-0.21655374765396118,
-0.14908379316329956,
0.29602017998695374,
-0.09220319241285324,
-0.14933039247989655,
-0.285501092672348,
-0.3744816780090332,
0.9601104259490967,
0.8158278465270996,
0.9429798126220703,
0.08993024379014969,
-0.649478554725647,
-0.24180933833122253,
0.2807433605194092,
-0.8497177362442017,
0.25217723846435547,
0.38385504484176636,
-0.37323519587516785,
-0.3956749141216278,
-0.15991932153701782,
0.030034739524126053,
0.6893302202224731,
-0.4488082528114319,
0.08622429519891739,
-0.11976070702075958,
0.13384976983070374,
-0.2526018023490906,
-0.39494043588638306,
-0.1620802879333496,
-0.3504413068294525,
0.41122153401374817,
-0.6739814281463623,
0.06466943770647049,
0.24396802484989166,
0.5893399715423584,
0.04623459279537201,
0.5372154712677002,
0.9817003011703491,
-0.33152180910110474,
-0.23472924530506134,
-0.08245522528886795,
-0.5899651646614075,
0.11660337448120117,
-0.2572421133518219,
0.12154420465230942,
-0.04712281376123428,
0.31178510189056396,
-5.7371649742126465,
-0.04606715217232704,
-0.19747294485569,
-0.12582643330097198,
-0.34567996859550476,
0.05398993939161301,
0.6488581299781799,
0.1301950216293335,
0.710261881351471,
-0.25049349665641785,
0.2826019823551178,
0.24732892215251923,
0.010488294064998627,
-0.15287867188453674,
-0.10633806884288788,
0.2324320375919342,
0.05108298733830452,
0.12102728337049484,
0.5594253540039062,
-0.1826111376285553,
0.07192601263523102,
-0.07779840379953384,
-0.19633974134922028,
0.22391697764396667,
-0.2280396968126297,
-0.3692243695259094,
-0.7068017721176147,
-0.005532834678888321,
-0.04748593643307686,
0.24404750764369965,
-0.4359534680843353,
-0.8397563099861145,
-0.1906222254037857,
-0.25751200318336487,
0.19512923061847687,
-0.006480358075350523,
-0.04130208119750023,
-0.5333539247512817,
-0.09464462846517563,
-0.12364853918552399,
0.6328074932098389,
0.4139989912509918,
-0.1353745311498642,
-0.15977421402931213,
0.16478100419044495,
-0.5664849281311035,
-0.050146881490945816,
0.06517809629440308,
-0.20012807846069336,
0.9448964595794678,
0.0004046158283017576,
-0.25477874279022217,
0.38919341564178467,
0.40813499689102173,
0.6883842349052429,
0.33213645219802856,
-0.10728370398283005,
0.21654431521892548,
-0.2851375937461853,
-0.12003394216299057,
-0.27828067541122437,
-0.2769317328929901,
-0.24885179102420807,
-0.36825722455978394,
0.378133624792099,
0.28877899050712585,
-0.8594354391098022,
-0.4470236003398895,
0.7453150153160095,
-0.11497007310390472,
-0.5605750679969788,
0.08763747662305832,
-0.01317606307566166,
-0.6206216216087341,
0.4948663115501404,
-0.6680580377578735,
0.06952628493309021,
-0.2754404842853546,
0.0009259446524083614,
-0.3304358124732971,
-0.7791861295700073,
-0.13103269040584564,
-0.4200621545314789,
-0.493647962808609,
0.19235274195671082,
-0.5325819849967957,
0.005436487030237913,
-0.2165459841489792,
-0.21943050622940063,
0.38934797048568726,
0.3848263621330261,
-0.3132644295692444,
0.06461089849472046,
0.2935278117656708,
0.7198379635810852,
0.327358603477478,
0.0764305591583252,
0.5362942814826965,
0.6414521336555481,
-0.09500043839216232,
0.9327942132949829,
-0.11590470373630524,
-0.6729901432991028,
-0.6901103258132935,
-0.06624948233366013,
0.3450286090373993,
-0.4483495056629181,
0.10510195791721344,
0.5610786080360413,
-0.30999499559402466,
-0.1928216964006424,
0.06905467808246613,
-0.36745667457580566,
-0.10671650618314743,
0.6348892450332642,
-0.35038259625434875,
0.0605669841170311,
0.6046756505966187,
0.6153858304023743,
-0.432888001203537,
0.27911385893821716,
0.500803530216217,
-0.3906414210796356,
0.5078674554824829,
0.08508400619029999,
-0.17849650979042053,
0.45297330617904663,
0.3075828552246094,
-0.3211227059364319,
-0.4614108204841614,
0.1010083556175232,
0.035027287900447845,
-0.045237958431243896,
-0.2751857340335846,
0.38544121384620667,
-0.16302216053009033,
-0.32906341552734375,
-0.24001026153564453,
0.10589580982923508,
-0.3108513057231903,
0.23630177974700928,
-0.18189330399036407,
-0.08694516867399216,
0.20309099555015564,
-0.18623220920562744,
0.3174423277378082,
-0.13720877468585968,
0.18407925963401794,
-0.28066596388816833,
0.037585776299238205,
-0.024815574288368225,
0.032609306275844574,
0.01508792582899332,
0.2506532073020935,
-0.7359103560447693,
0.3032759726047516,
0.6964027881622314,
-0.05922424793243408,
0.5903040766716003,
-0.42413434386253357,
0.3058062493801117,
0.6537930369377136,
-0.7614786028862,
0.3357066810131073,
-0.24277858436107635,
-0.15504090487957,
-0.010165784507989883,
-0.04894019290804863,
-0.02543722838163376,
0.05120065063238144,
-0.6273280382156372,
-0.2446417510509491,
0.25233206152915955,
-0.22265155613422394,
-0.1327928751707077,
0.03820380941033363,
-0.11464305222034454,
0.1551038771867752,
-0.262973815202713,
0.011690144427120686,
0.20191249251365662,
-0.5514229536056519,
-0.39060714840888977,
0.6672001481056213,
0.3322250247001648,
0.5570539832115173,
0.007623623125255108,
-0.24311034381389618,
-0.4539167881011963,
-0.21489445865154266,
0.19394122064113617,
0.16932553052902222,
0.08243345469236374,
-0.43989768624305725,
0.1165744811296463,
0.09144844859838486,
-0.2778911292552948,
0.40330636501312256,
-0.13956817984580994,
-0.4966924786567688,
0.036806292831897736,
0.35751357674598694,
-0.6135062575340271,
0.46892738342285156,
0.09329050034284592,
0.24925220012664795,
-0.03719083592295647,
-0.1650998294353485,
0.483174592256546,
-0.3606390655040741,
-0.1652049720287323,
-0.22518470883369446,
0.21889372169971466,
0.5814816951751709,
-0.12607724964618683,
0.7004191279411316,
-0.10324420779943466,
-0.2804044485092163,
0.30948203802108765,
0.28897616267204285,
0.06966772675514221,
0.00921179074794054,
-0.005881138611584902,
-0.36059367656707764,
-0.20870737731456757,
0.9684813022613525,
0.2263791263103485,
-0.8933104276657104,
-0.0651123970746994,
0.15691858530044556,
0.051926612854003906,
-0.3963976204395294,
0.015766773372888565,
0.08241687715053558,
-0.6221379637718201,
-0.5322935581207275,
0.006605897098779678,
-0.28908154368400574,
0.11791714280843735,
0.5818430185317993,
0.6835295557975769,
0.12294504046440125,
-0.8127806186676025,
0.09519828855991364,
-0.020401164889335632,
0.5536631345748901,
0.8381489515304565,
-0.7717364430427551,
-0.9120758175849915,
-0.18924486637115479,
0.33136504888534546,
-0.33355891704559326,
-0.1803330034017563,
0.15760961174964905,
0.990118682384491,
0.3714773654937744,
0.10042968392372131,
-0.21581654250621796,
-0.20190666615962982,
-0.3813537359237671,
-0.185869500041008,
-0.256255567073822,
-0.4909186065196991,
-0.13787858188152313,
-0.034285057336091995,
-0.010112548246979713,
-0.3918299674987793,
-0.5897787809371948,
0.3584164083003998,
0.029395190998911858,
-0.4363769590854645,
-0.023403644561767578,
0.835289478302002,
0.19599810242652893,
-0.20604173839092255,
0.6229100823402405,
-0.07103043794631958,
0.4820064604282379,
-0.1737053394317627,
0.5892685651779175,
-0.6573981046676636,
-0.5484115481376648,
0.4509468078613281,
-0.04433891177177429,
0.5342622995376587,
-0.23032167553901672,
-0.012334305793046951,
-0.5573223829269409,
0.025714881718158722,
-0.21041353046894073,
-0.22440789639949799,
-0.22888009250164032,
-0.4568805992603302,
-0.6029584407806396,
0.3577091097831726,
0.4635712206363678,
0.28339478373527527,
0.06819110363721848,
-0.2542283833026886,
-0.14526508748531342,
-0.699403703212738,
0.9024524092674255,
0.5014061331748962,
-1.0133116245269775,
0.268433153629303,
-0.043317198753356934,
0.200932115316391,
0.3257068991661072,
-0.33298954367637634,
-0.11626537144184113,
-0.1683834046125412,
0.06986157596111298,
0.21400025486946106,
-0.17036038637161255,
-0.3884637951850891,
0.45190802216529846,
0.2687593102455139,
-0.4708808660507202,
0.32059451937675476,
-0.0978359580039978,
0.035867106169462204,
0.6956992149353027,
-0.10094526410102844,
-0.07946790009737015,
-0.5511699318885803,
0.2998288571834564,
0.07867549359798431,
-0.2618846297264099,
-0.3575728237628937,
0.5433237552642822,
0.9835397005081177,
0.03808597847819328,
-0.34435033798217773,
0.26513874530792236,
0.07694128900766373,
0.25656184554100037,
-0.015465294010937214,
-0.4585534334182739,
-0.1848495900630951,
0.12176980078220367,
0.787222146987915,
0.70775306224823,
-0.4703409671783447,
0.20065897703170776,
-0.2298721820116043,
0.44650235772132874,
-0.09331977367401123,
0.23794837296009064,
-0.05927663296461105,
0.09744645655155182,
0.39093801379203796,
-0.2802141308784485,
-0.024946505203843117,
0.27998653054237366,
-0.2665746808052063,
-0.2082994282245636,
0.5704062581062317,
-0.1855745017528534,
-0.10356311500072479,
0.3132798373699188,
-0.1623222976922989,
0.5775222182273865,
0.35617032647132874,
0.7203976511955261,
-0.11483657360076904,
0.16048714518547058,
0.24917130172252655,
-0.07050817459821701,
0.042075324803590775,
-0.43839994072914124,
0.13159894943237305,
-0.07607346028089523,
-0.3771499991416931,
0.25780540704727173,
-0.20746180415153503,
-0.15376275777816772,
-0.21939240396022797,
0.15766090154647827,
0.050858426839113235,
0.3520779013633728,
-0.3860414922237396,
-0.2640649080276489,
0.054149847477674484,
-0.48110541701316833,
-0.2314719408750534,
0.16334529221057892,
-0.1722382754087448,
-0.12289922684431076,
0.22626979649066925,
0.18013982474803925,
0.25182923674583435,
-0.6766144633293152,
0.3463544249534607,
0.09579606354236603,
0.43543460965156555,
0.20198771357536316,
-0.2203432321548462,
0.4336721897125244,
0.14984099566936493,
0.5661142468452454,
0.0268530435860157,
0.5098268389701843,
-0.1756357103586197,
0.23760418593883514,
-0.6510927081108093,
0.5977559089660645,
-0.04861592501401901,
0.007367037236690521,
-0.9245234727859497,
0.07771115750074387,
1.101159930229187,
0.47343331575393677,
-0.20146937668323517,
0.18388931453227997,
0.10633265227079391,
0.3354727029800415,
0.08901041001081467,
-0.4778824746608734,
0.20404905080795288,
-0.6380149722099304,
-0.3444910943508148,
-0.7965545058250427,
0.6069633364677429,
0.028781671077013016,
-0.034215573221445084,
-0.05715968459844589,
0.5442093014717102,
0.6196191906929016,
-0.3765396177768707,
0.34368249773979187,
0.28204330801963806,
0.1976528912782669,
-0.5122271180152893,
0.30764535069465637,
-0.46745961904525757,
0.06500345468521118,
-0.3513859212398529,
0.3281678855419159,
0.26719680428504944,
-0.13001063466072083,
0.6487225890159607,
0.06445727497339249,
-0.413582980632782,
0.10197903960943222,
0.11502669006586075,
-0.09975183010101318,
-0.20363187789916992,
-0.36993303894996643,
-0.7094973921775818,
0.4518674314022064,
-0.03976265713572502,
-0.2956324815750122,
0.05416756868362427,
0.3395596444606781,
-0.23522613942623138,
0.08749810606241226,
0.04199324548244476,
-0.13956816494464874,
-0.1832444667816162,
0.2337287813425064
] |
Newcastle Disease Virus (NDV) is a pathogenic strain of avian paramyxovirus (aPMV-1) that is among the most serious of disease threats to the poultry industry worldwide. Viral diversity is high in aPMV-1; eight genotypes are recognized based on phylogenetic reconstruction of gene sequences. Modified live vaccines have been developed to decrease the economic losses caused by this virus. Vaccines derived from avirulent genotype II strains were developed in the 1950s and are in use globally, whereas Australian strains belonging to genotype I were developed as vaccines in the 1970s and are used mainly in Asia. In this study, we evaluated the consequences of attenuated live virus vaccination on the evolution of aPMV-1 genotypes. There was phylogenetic incongruence among trees based on individual genes and complete coding region of 54 full length aPMV-1 genomes, suggesting that recombinant sequences were present in the data set. Subsequently, five recombinant genomes were identified, four of which contained sequences from either genotype I or II. The population history of vaccine-related genotype II strains was distinct from other aPMV-1 genotypes; genotype II emerged in the late 19(th) century and is evolving more slowly than other genotypes, which emerged in the 1960s. Despite vaccination efforts, genotype II viruses have experienced constant population growth to the present. In contrast, other contemporary genotypes showed population declines in the late 1990s. Additionally, genotype I and II viruses, which are circulating in the presence of homotypic vaccine pressure, have unique selection profiles compared to nonvaccine-related strains. Collectively, these data show that vaccination with live attenuated viruses has changed the evolution of aPMV-1 by maintaining a large effective population size of a vaccine-related genotype, allowing for coinfection and recombination of vaccine and wild type strains, and by applying unique selective pressures on viral glycoproteins. | [
-0.013048973865807056,
0.014981036074459553,
-0.004260217770934105,
0.007100478745996952,
-0.024743124842643738,
-0.022026101127266884,
0.0070549845695495605,
0.035750363022089005,
-0.008951103314757347,
-0.012533312663435936,
-0.013083999045193195,
0.011370886117219925,
-0.00022040389012545347,
0.005516781471669674,
0.0020628422498703003,
0.02040335349738598,
-0.006395702715963125,
0.0011049855966120958,
0.006670822389423847,
-0.03094540908932686,
-0.0021138382144272327,
0.00037953513674438,
0.007972979918122292,
-0.005778846796602011,
-0.0020847413688898087,
0.03395771235227585,
0.007419908419251442,
0.003007248044013977,
0.011038171127438545,
0.027513477951288223,
-0.003556232899427414,
-0.008620223961770535,
0.0023607767652720213,
-0.01753106713294983,
-0.017978578805923462,
-0.001909894635900855,
-0.00231927284039557,
0.017369642853736877,
0.0017152875661849976,
-0.005243102088570595,
0.006318648345768452,
-0.009941605851054192,
0.006580304354429245,
-0.018468156456947327,
-0.008311369456350803,
-0.02835642173886299,
-0.003407700452953577,
0.004596126731485128,
-0.026005305349826813,
0.0030294032767415047,
-0.011824741028249264,
0.009302549064159393,
-0.005770975723862648,
-0.0028980292845517397,
-0.004941993393003941,
-0.02782883681356907,
0.014347697608172894,
0.011881604790687561,
0.002955865114927292,
0.010426705703139305,
0.009475772269070148,
-0.002568143652752042,
-0.017277713865041733,
-0.019973592832684517,
-0.000778567511588335,
-0.06762450933456421,
0.012213831767439842,
0.01105484738945961,
0.0014462305698543787,
0.01018434576690197,
0.011698493734002113,
0.007596413139253855,
-0.008254890330135822,
0.013517007231712341,
0.0013541923835873604,
0.006541775073856115,
-0.003437112318351865,
0.011395828798413277,
0.0067330836318433285,
0.004540423862636089,
-0.012316370382905006,
0.0076932143419981,
0.0007800698513165116,
0.012611674144864082,
-0.0043169232085347176,
0.015559589490294456,
-0.01875065267086029,
0.006059939041733742,
0.01304226741194725,
-0.006918426603078842,
0.021944349631667137,
-0.02277465909719467,
-0.027919430285692215,
-0.028404541313648224,
0.0009191781282424927,
-0.0027265511453151703,
0.005175176076591015,
0.012678287923336029,
0.015859704464673996,
-0.010104455053806305,
-0.0007504647364839911,
0.0034948824904859066,
0.0060278745368123055,
-0.011327856220304966,
-0.005578002892434597,
0.00376902986317873,
-0.008525128476321697,
-0.008803939446806908,
0.025459997355937958,
0.005842715501785278,
0.00009262003004550934,
-0.006497794762253761,
0.003217346267774701,
0.04332952946424484,
-0.02093835175037384,
-0.003794793039560318,
0.025982871651649475,
0.006020927801728249,
0.002501546870917082,
0.011125009506940842,
0.006718870252370834,
-0.007958473637700081,
-0.006526326760649681,
0.019758932292461395,
0.0069458093494176865,
0.0020285695791244507,
0.0015949462540447712,
-0.016749944537878036,
0.032621998339891434,
-0.0007656088564544916,
-0.007111080922186375,
0.0014467353466898203,
-0.007381239905953407,
-0.005481810308992863,
0.017264433205127716,
0.0043537369929254055,
0.010259853675961494,
-0.02361084148287773,
-0.015142873860895634,
-0.01169552467763424,
0.01347796618938446,
0.0035289886873215437,
0.002499809954315424,
0.0025752962101250887,
-0.002039744984358549,
0.007238209247589111,
-0.014852290973067284,
0.0035503196995705366,
0.012574398890137672,
0.008574256673455238,
-0.0031981496140360832,
-0.02253022976219654,
-0.0038250857032835484,
-0.0007312972447834909,
0.003203151747584343,
-0.017135784029960632,
-0.012038791552186012,
0.00556896673515439,
-0.016030196100473404,
0.027891090139746666,
-0.003985337447375059,
-0.01139218918979168,
-0.011534465476870537,
0.006103657651692629,
0.00968597736209631,
0.0035652793012559414,
0.012309718877077103,
-0.004811802878975868,
-0.008120312355458736,
0.007084457669407129,
0.0012679367791861296,
0.0075542256236076355,
0.009267833083868027,
0.008423163555562496,
0.010647909715771675,
-0.0001826620427891612,
0.015656249597668648,
0.005186622031033039,
-0.01850561797618866,
0.06708985567092896,
0.017125528305768967,
0.01572302170097828,
-0.00013117073103785515,
-0.0037455344572663307,
0.01617882028222084,
-0.022496892139315605,
0.003416205756366253,
-0.013313607312738895,
-0.0065102344378829,
-0.007896391674876213,
-0.018982350826263428,
0.028767477720975876,
-0.00376756489276886,
0.015804007649421692,
0.01186763122677803,
0.002625207882374525,
-0.02280079945921898,
-0.004993469920009375,
0.013129823841154575,
0.00573472585529089,
0.02361462265253067,
-0.003388001350685954,
0.0021016260143369436,
-0.01938439905643463,
-0.04506929591298103,
0.005850143730640411,
0.004229592625051737,
0.004899180959910154,
-0.00773349916562438,
-0.008602002635598183,
-0.003900245763361454,
-0.008415523916482925,
0.00284438394010067,
-0.005267980508506298,
-0.00794035755097866,
-0.010660044848918915,
-0.00809796154499054,
0.002483935095369816,
0.007985126227140427,
-0.008127969689667225,
-0.014660144224762917,
0.01503379363566637,
-0.017198879271745682,
0.011047624051570892,
0.012283578515052795,
0.02659929171204567,
0.01762760803103447,
0.01027263980358839,
-0.00510919326916337,
0.0034166895784437656,
-0.0026360698975622654,
-0.018099870532751083,
-0.010096052661538124,
-0.005469146650284529,
0.007965615019202232,
-0.00890430063009262,
0.012893409468233585,
-0.00003857957199215889,
-0.0011296013835817575,
-0.013883348554372787,
0.0008374960743822157,
-0.00014635780826210976,
-0.003511110320687294,
0.007107268553227186,
0.010352112352848053,
-0.007757858373224735,
-0.013269174844026566,
-0.006030710879713297,
-0.010683171451091766,
0.0011028447188436985,
0.008074999786913395,
0.013725649565458298,
0.01364701334387064,
-0.03664214909076691,
-0.0070867822505533695,
-0.0008245615754276514,
0.02959105558693409,
-0.01315009780228138,
0.020612280815839767,
-0.0008925474248826504,
0.012988513335585594,
0.006058705970644951,
-0.007225183770060539,
-0.0273151695728302,
-0.0031955260783433914,
0.03490880876779556,
0.001137251267209649,
0.012304634787142277,
-0.017649905756115913,
-0.007822859100997448,
0.007709691766649485,
-0.006930676754564047,
0.0003097209264524281,
-0.08146082609891891,
-0.006967430002987385,
0.013795869424939156,
-0.0328633077442646,
0.002482827752828598,
0.00882936455309391,
0.010066979564726353,
0.0038363768253475428,
-0.01565593294799328,
-0.0030874069780111313,
0.02141420543193817,
-0.0011710107792168856,
-0.01377160008996725,
-0.008332985453307629,
0.024232126772403717,
-0.014705771580338478,
0.012587735429406166,
0.028140172362327576,
-0.02261088788509369,
-0.033366575837135315,
0.009659558534622192,
0.02454078197479248,
0.039606817066669464,
-0.01755697838962078,
-0.016661567613482475,
-0.001170299481600523,
0.01106703095138073,
0.021511629223823547,
-0.014734305441379547,
0.005054201930761337,
0.01936379075050354,
-0.005887533538043499,
0.024411972612142563,
-0.01075882650911808,
0.0006607077084481716,
0.011951752007007599,
-0.008213624358177185,
-0.005421548616141081,
0.0009106453508138657,
0.008419395424425602,
-0.006627894937992096,
0.013679124414920807,
0.014370312914252281,
-0.0024173434358090162,
0.0082709901034832,
-0.005574618000537157,
0.004143713042140007,
-0.01355893537402153,
0.016355520114302635,
-0.00004491955041885376,
0.014038294553756714,
-0.006907806731760502,
0.045193180441856384,
0.012477099895477295,
-0.007022629491984844,
0.0007157954387366772,
-0.005560413468629122,
0.012812424451112747,
-0.003102022223174572,
0.00021212553838267922,
-0.014934337697923183,
0.004404313862323761,
-0.014247192069888115,
0.016937391832470894,
0.0012560426257550716,
0.019661804661154747,
0.016228115186095238,
-0.006129075773060322,
0.0030855126678943634,
-0.0014458457008004189,
0.008622915484011173,
-0.000650996807962656,
-0.0013327080523595214,
-0.005186556372791529,
0.010569272562861443,
-0.003124506212770939,
-0.009046752005815506,
-0.01114374678581953,
-0.009564955718815327,
-0.008488121442496777,
-0.01647765375673771,
0.017507188022136688,
-0.0021318153012543917,
0.016802717000246048,
-0.01023370586335659,
-0.004254024475812912,
0.008945845067501068,
0.018552221357822418,
0.008725959807634354,
-0.009580068290233612,
0.017330560833215714,
0.0058511425741016865,
-0.006459358148276806,
0.010677292011678219,
-0.022527925670146942,
-0.015390627086162567,
0.016557011753320694,
0.00843135453760624,
0.00608441885560751,
0.007231460884213448,
0.008610480464994907,
-0.0024096453562378883,
0.008420257829129696,
-0.008203007280826569,
-0.019046101719141006,
0.0145029341802001,
0.012243972159922123,
0.023378975689411163,
-0.014579663053154945,
0.0024852908682078123,
0.01548346783965826,
0.003973821643739939,
-0.0044735814444720745,
-0.025045575574040413,
0.0126557108014822,
-0.013686448335647583,
0.0001343477051705122,
-0.014218375086784363,
0.07318350672721863,
0.02584034763276577,
0.01399361900985241,
-0.0006180445197969675,
0.0066777924075722694,
-0.010829450562596321,
0.0027241602074354887,
-0.0007453099824488163,
-0.019820190966129303,
0.0053465841338038445,
0.008559824898838997,
-0.009665209800004959,
-0.013958282768726349,
-0.02811739593744278,
0.005274016875773668,
-0.005213432013988495,
0.03199583292007446,
-0.01874050870537758,
-0.004645426757633686,
0.018220681697130203,
0.00999361090362072,
-0.01059875637292862,
-0.005796695128083229,
0.0033765563275665045,
-0.014406600967049599,
0.02447039820253849,
0.008559530600905418,
-0.009114577434957027,
0.0072767483070492744,
0.005659108050167561,
-0.007447316776961088,
-0.015129436738789082,
-0.009505201131105423,
-0.0018864665180444717,
0.01681576669216156,
-0.006587734445929527,
-0.026145806536078453,
0.0036184010095894337,
0.007570741698145866,
-0.018451863899827003,
-0.034522347152233124,
-0.01382427103817463,
0.0010782275348901749,
0.0011387210106477141,
-0.010894211940467358,
0.013756302185356617,
-0.0017817122861742973,
-0.006965345703065395,
-0.004674198105931282,
-0.010918224230408669,
-0.0027761172968894243,
0.0008568471530452371,
0.011277919635176659,
0.02904907613992691,
0.000022176187485456467,
-0.0018115239217877388,
-0.004172858782112598,
-0.0011202958412468433,
-0.013088176026940346,
-0.0029198750853538513,
0.02456917241215706,
-0.03643481433391571,
-0.01297406293451786,
0.0010955433826893568,
0.01069331169128418,
-0.01468635629862547,
0.0029406051617115736,
-0.0014227922074496746,
-0.028321176767349243,
-0.0029048696160316467,
-0.017655711621046066,
0.014198292046785355,
-0.02046595886349678,
-0.015395941212773323,
-0.023335855454206467,
-0.008744226768612862,
-0.002708645537495613,
0.002163135912269354,
0.0028726141899824142,
-0.008131123147904873,
0.007644249126315117,
-0.004580767825245857,
0.008844638243317604,
-0.002007518894970417,
-0.006695720367133617,
0.010235818102955818,
0.008301003836095333,
-0.07479441165924072,
0.006035781931132078,
-0.009468598291277885,
-0.0024688774719834328,
0.002115967683494091,
0.001751266187056899,
-0.007368818391114473,
-0.017549606040120125,
-0.0012331048492342234,
-0.00024178053718060255,
0.0031514307484030724,
-0.009125723503530025,
0.010774446651339531,
0.0013958970084786415,
0.012838663533329964,
0.02357170730829239,
-0.020415958017110825,
0.018682677298784256,
-0.006920569576323032,
0.002028032671660185,
0.0136023610830307,
0.009287109598517418,
-0.019940465688705444,
0.002027846174314618,
-0.011593409813940525,
-0.08217745274305344,
-0.011449947953224182,
0.005504777189344168,
-0.004085307940840721,
-0.01873493194580078,
0.0004858989268541336,
0.018111418932676315,
-0.011798492632806301,
0.008292200043797493,
-0.009700339287519455,
0.010386841371655464,
0.0072386800311505795,
0.007377758156508207,
0.003626140533015132,
-0.002907572779804468,
-0.008761078119277954,
0.005797591991722584,
-0.00028381613083183765,
0.0018572364933788776,
-0.0075560202822089195,
0.00516165466979146,
0.019720662385225296,
-0.004867297597229481,
-0.018079470843076706,
-0.007335069123655558,
0.006255418062210083,
-0.020097360014915466,
0.010971005074679852,
-0.008150184527039528,
-0.038529057055711746,
0.016161160543560982,
-0.010321510955691338,
-0.004847021773457527,
-0.01907704770565033,
0.005508070811629295,
-0.012586739845573902,
0.020115289837121964,
0.0021768659353256226,
0.011813979595899582,
-0.015578102320432663,
-0.006186272948980331,
0.0034801578149199486,
-0.004440557211637497,
0.016686279326677322,
-0.008280808106064796,
0.0012893863022327423,
0.007369824685156345,
-0.012605641037225723,
0.013470394536852837,
-0.024528807029128075,
0.003753236262127757,
-0.017295777797698975,
0.011376575566828251,
-0.012014450505375862,
-0.007682676427066326,
-0.018096087500452995,
-0.004184868652373552,
0.011963372118771076,
0.000176203902810812,
0.011685088276863098,
-0.00589488772675395,
-0.014620991423726082,
0.01771407574415207,
0.07241463661193848,
-0.004563089460134506,
0.0047811707481741905,
-0.015214717015624046,
-0.0013851136900484562,
0.007854492403566837,
-0.004580433014780283,
0.012803643941879272,
0.0004615213256329298,
-0.010418900288641453,
0.008431382477283478,
0.0009865458123385906,
-0.006672323681414127,
0.007783239707350731,
-0.0246445219963789,
-0.004877978004515171,
0.0324048288166523,
0.010318895801901817,
0.020157791674137115,
0.0031497213058173656,
-0.0023960894905030727,
-0.0029132571071386337,
-0.01814083196222782,
-0.0059753647074103355,
0.017833054065704346,
-0.00045222637709230185,
0.0015075418632477522,
-0.03024008497595787,
-0.001850111410021782,
0.005066987592726946,
0.019850576296448708,
-0.005449380725622177,
0.0021941864397376776,
-0.02071847766637802,
0.01259090006351471,
0.011745217256247997,
0.0035753468982875347,
0.010128526017069817,
0.0024326015263795853,
0.017312228679656982,
0.008133303374052048,
0.015326390042901039,
-0.0012119612656533718,
0.00026923592668026686,
0.03522339090704918,
-0.020134657621383667,
0.013581683859229088,
-0.0012167347595095634,
0.022074516862630844,
0.0017630538204684854,
0.03240180015563965,
0.003980988636612892,
0.03220803663134575,
0.011790910735726357,
-0.007310314103960991,
-0.014753330498933792,
-0.02400425635278225,
0.005117082502692938,
-0.0018332444597035646,
-0.0038586047012358904,
0.018273402005434036,
-0.015792079269886017,
-0.0036429408937692642,
-0.010545013472437859,
0.0073450286872684956,
-0.025109846144914627,
0.0006269350415095687,
-0.021185705438256264,
-0.02073514647781849,
0.01049734465777874,
0.020517908036708832,
0.0020414432510733604,
0.006829423364251852,
0.00453523825854063,
0.02717091701924801,
0.009203802794218063,
0.0019932184368371964,
0.0016096922336146235,
0.020296934992074966,
-0.006828594952821732,
-0.00870980229228735,
-0.019350679591298103,
-0.005941730458289385,
0.012426778674125671,
0.010939192958176136,
0.002899312414228916,
0.012432068586349487,
-0.006013965234160423,
-0.0023534432984888554,
0.0040906332433223724,
0.020941780880093575,
0.0019438733579590917,
0.0088893948122859,
-0.008975647389888763,
0.010705161839723587,
0.03212851658463478,
-0.02156088314950466,
0.0050811367109417915,
0.01859421655535698,
-0.015697190538048744,
0.025349078699946404,
-0.0219859778881073,
-0.019682947546243668,
-0.003411127021536231,
0.003598134033381939,
0.015693217515945435,
0.020781204104423523,
-0.025177624076604843,
-0.008203648030757904,
0.013126486912369728,
0.005717413499951363,
0.004635882098227739,
-0.010762244462966919,
0.00975850224494934,
-0.01150346826761961,
-0.00322335003875196,
-0.012689324095845222,
0.010623055510222912,
0.011680511757731438,
-0.014598216861486435,
-0.027535786852240562,
-0.010108573362231255,
0.02920287847518921,
0.013000322505831718,
-0.03272192180156708,
-0.02374528907239437,
-0.0125195924192667,
-0.0013741804286837578,
-0.016982533037662506,
-0.007983120158314705,
0.01059190183877945,
-0.026252344250679016,
-0.003620557487010956,
-0.008863139897584915,
0.001965857110917568,
-0.021683139726519585,
0.009405361488461494,
-0.018003996461629868,
-0.010145292617380619,
-0.029394641518592834,
0.0011730547994375229,
0.0019598191138356924,
-0.002827171701937914,
-0.027964066714048386,
0.007760051637887955,
-0.013873858377337456,
-0.005175946280360222,
-0.014504383318126202,
0.007720268331468105,
-0.00112386594992131,
-0.00003224634565412998,
-0.00391256483271718,
-0.01248633861541748,
-0.006953310687094927,
0.02103540115058422,
-0.002035049721598625,
0.00875003170222044,
0.001946810050867498,
0.001560396165587008,
0.016302652657032013,
0.011323527432978153,
0.009694719687104225,
0.03772590309381485,
0.02764202281832695,
-0.006622807122766972,
0.0038377977907657623,
-0.008279846981167793,
0.02200232818722725,
-0.02133282832801342,
0.024266226217150688,
0.0021175951696932316,
0.004064984619617462,
0.010405389592051506,
0.01610598899424076,
-0.017176106572151184,
-0.002579205669462681,
0.003206635592505336,
-0.011690429411828518,
0.0005176682025194168,
0.016841156408190727,
0.012783341109752655,
-0.02655147761106491,
-0.00042066466994583607,
-0.007891136221587658,
-0.018659455701708794,
0.0018889806233346462,
-0.007553800009191036,
0.020741237327456474,
-0.0042609828524291515,
-0.002175999339669943,
-0.022641293704509735,
-0.007786721456795931,
0.010416047647595406,
0.0011344985105097294,
0.002537910360842943,
-0.008909797295928001,
-0.03286159038543701,
0.007232839707285166,
0.011253844946622849,
0.004945879802107811,
0.004526414908468723,
-0.00761193735525012
] | [
0.022404542192816734,
-0.04637434333562851,
-0.4282180964946747,
-0.62294602394104,
-0.021065955981612206,
0.6676705479621887,
0.3405624032020569,
0.6436437964439392,
-0.47143036127090454,
-0.3946742117404938,
-0.15289586782455444,
0.06802564859390259,
-0.8364366292953491,
0.45316576957702637,
0.40428078174591064,
0.7005785703659058,
0.4183681011199951,
0.16442164778709412,
-0.6974472403526306,
-0.0006690164445899427,
-0.2293296605348587,
-0.9866136908531189,
0.6199418902397156,
0.33588215708732605,
0.549227237701416,
-0.6782201528549194,
0.38917064666748047,
0.15479591488838196,
0.32605305314064026,
-0.000294633413432166,
0.5638343095779419,
0.6200520396232605,
0.1665646880865097,
-0.08287031948566437,
-0.32354068756103516,
0.13691915571689606,
-0.4701794385910034,
-0.0038127272855490446,
-0.10741372406482697,
-0.15727251768112183,
-0.12163793295621872,
-0.7557222247123718,
-0.10165610909461975,
0.28575995564460754,
-0.18534688651561737,
-0.3943084180355072,
-0.8602521419525146,
0.5929118394851685,
0.1623837649822235,
-0.02664116583764553,
0.04931460693478584,
0.3208444118499756,
-0.21870382130146027,
-0.17432278394699097,
0.6133486032485962,
0.08846413344144821,
-0.4423503577709198,
-0.3383464813232422,
-0.10971291363239288,
-0.5895599126815796,
0.14318905770778656,
0.11892996728420258,
0.07314673811197281,
0.48004865646362305,
-0.0740056037902832,
1.0283881425857544,
-0.006030253134667873,
0.8768269419670105,
-0.1976211965084076,
-0.07071957737207413,
-0.6801388263702393,
-0.18021260201931,
-0.1255597621202469,
-0.08265943825244904,
-0.021831830963492393,
-0.19212691485881805,
-0.32114648818969727,
-0.29907912015914917,
0.3056579828262329,
0.18474045395851135,
-0.006089681293815374,
0.4449250400066376,
0.10848914086818695,
-0.37423351407051086,
0.9284961223602295,
0.1276164948940277,
-0.16588859260082245,
0.7502316236495972,
-0.2083716243505478,
-0.14147481322288513,
0.32279831171035767,
0.39947280287742615,
0.5031792521476746,
0.181010901927948,
-0.2538735568523407,
0.4823716878890991,
-0.3097139596939087,
0.07311557978391647,
0.3065563142299652,
-0.3003520369529724,
-0.1338287591934204,
-0.17513464391231537,
-0.3616209328174591,
-0.21954363584518433,
-0.16107924282550812,
0.232681006193161,
0.2198675274848938,
-0.6744271516799927,
-0.04439440369606018,
0.147226482629776,
-0.8119488954544067,
-0.19756770133972168,
-0.054773785173892975,
-0.4353572726249695,
-0.11910056322813034,
0.23606440424919128,
-0.22217829525470734,
-0.3905116021633148,
0.40611210465431213,
-0.36600783467292786,
-0.29346609115600586,
0.541102409362793,
-0.7906606793403625,
0.9404091835021973,
-0.19089514017105103,
-0.008656133897602558,
-0.09254775196313858,
0.36052826046943665,
-0.3488405644893646,
0.2859591245651245,
-0.06807003915309906,
0.8471871018409729,
-0.17457075417041779,
-0.007913846522569656,
0.22751858830451965,
0.6000227928161621,
-0.6475672721862793,
0.4223235249519348,
0.24668444693088531,
-0.07293342053890228,
-0.8779290914535522,
-0.43299400806427,
0.09149506688117981,
-0.018677422776818275,
-0.2684434950351715,
-0.2616308629512787,
-0.05279726907610893,
-0.2795678377151489,
0.40034064650535583,
-0.3982318937778473,
0.054324112832546234,
-0.6478440165519714,
-0.6302276253700256,
0.12343621999025345,
-0.3287932574748993,
-0.2889731526374817,
-0.06999050080776215,
-0.3150312304496765,
0.06294017285108566,
0.265322208404541,
0.4334184229373932,
0.4450102150440216,
-0.4586147665977478,
-0.021073564887046814,
0.2910321354866028,
-0.2506535053253174,
-0.2792584300041199,
-0.005332030355930328,
0.32121679186820984,
-0.3299770951271057,
-0.42537230253219604,
-0.2813470959663391,
0.43371954560279846,
-0.2769801914691925,
-0.25762611627578735,
0.06327251344919205,
0.2910477817058563,
-0.12317320704460144,
0.49417728185653687,
0.24161189794540405,
-0.5120732188224792,
-0.1448739618062973,
0.24651145935058594,
0.4277111887931824,
0.20274730026721954,
-0.030607813969254494,
-0.09959183633327484,
-0.3330404758453369,
0.10645866394042969,
0.3975732922554016,
-0.2521460950374603,
-0.1052822545170784,
0.5901914238929749,
-0.564869225025177,
1.0536412000656128,
-0.013475480489432812,
-0.33325910568237305,
1.2356805801391602,
0.016543518751859665,
0.036777034401893616,
0.306691437959671,
-0.06919188797473907,
0.48408043384552,
-0.40796107053756714,
-0.9755876660346985,
0.10867077857255936,
-0.017454789951443672,
-0.26165860891342163,
-0.0273833516985178,
-0.2676091492176056,
0.10423646867275238,
-0.5277723073959351,
0.24238087236881256,
-0.6108680367469788,
0.38691872358322144,
0.17020843923091888,
-0.32553234696388245,
0.2192544937133789,
0.1497707962989807,
-0.6571834683418274,
0.20358797907829285,
-0.3177923560142517,
0.32865411043167114,
0.24742978811264038,
0.22064942121505737,
0.5829566717147827,
0.5024691820144653,
-0.48096293210983276,
0.8881665468215942,
-0.533491313457489,
0.47545915842056274,
0.0033230516128242016,
0.11557384580373764,
-0.2778171896934509,
-0.18560925126075745,
-0.17834791541099548,
0.016900407150387764,
-0.010103739798069,
-0.1532621681690216,
0.28185340762138367,
0.18846675753593445,
0.826694130897522,
-1.2415828704833984,
0.35698622465133667,
-0.02540545165538788,
-0.27834033966064453,
-0.04350600019097328,
-0.2281981259584427,
-0.4813106060028076,
0.5723100304603577,
0.3961561620235443,
0.43280044198036194,
0.4488263428211212,
-0.11506502330303192,
-0.2836620509624481,
0.21866042912006378,
-0.30439993739128113,
-0.20992010831832886,
0.19373877346515656,
-0.27135321497917175,
-0.8166791200637817,
-0.4787384867668152,
-0.30836060643196106,
0.32903000712394714,
-0.05041934549808502,
-0.5289967656135559,
0.05807969719171524,
-0.26629820466041565,
0.3327854871749878,
-0.1169743463397026,
0.795694887638092,
0.3471192419528961,
-0.8919820189476013,
-0.11790306866168976,
0.1457989662885666,
-0.4644305109977722,
0.2844781279563904,
0.8260694742202759,
-0.5921958088874817,
-0.3312680125236511,
-0.3798469007015228,
0.6327691674232483,
0.2191673070192337,
-0.9441168308258057,
0.38334330916404724,
-0.07291541993618011,
-0.15730176866054535,
-0.4855459928512573,
-0.6033639311790466,
-0.1801854819059372,
-0.4630962610244751,
0.11768703162670135,
-0.22968260943889618,
0.33442553877830505,
0.0018779226811602712,
-0.19902095198631287,
0.10216788947582245,
0.5489190220832825,
0.8052794337272644,
-0.03642375394701958,
0.06485141813755035,
0.3397890031337738,
-0.3277748227119446,
0.12299921363592148,
0.016132377088069916,
0.057897381484508514,
-0.01514639612287283,
-0.5210107564926147,
-5.747707366943359,
0.37852033972740173,
0.3172251582145691,
-0.36926397681236267,
0.21391072869300842,
0.5203408002853394,
0.5010691285133362,
0.3393758535385132,
0.35278573632240295,
0.12314989417791367,
0.2787887454032898,
0.0977102741599083,
0.15204139053821564,
-0.3033865988254547,
-0.23077473044395447,
0.04351748898625374,
-0.03437204658985138,
-0.36097586154937744,
0.34510329365730286,
-0.18030543625354767,
0.4382956922054291,
-0.08420007675886154,
-0.17206422984600067,
0.2114950269460678,
0.2427464723587036,
0.6123268008232117,
-0.8419708013534546,
0.17213468253612518,
-0.40076372027397156,
-0.09570061415433884,
0.17420707643032074,
-1.0299768447875977,
0.005680060014128685,
-0.3037765920162201,
-0.690833568572998,
-0.3573443293571472,
0.22339703142642975,
-0.266994446516037,
-0.5017774105072021,
-0.10749278962612152,
-0.09510423243045807,
0.18631252646446228,
0.08432073891162872,
-0.44516322016716003,
0.2313457429409027,
-0.1541784256696701,
-0.177181676030159,
-0.5374470949172974,
-0.318185955286026,
0.6590405702590942,
-0.04466017335653305,
0.13514594733715057,
0.36510100960731506,
0.7625690698623657,
0.31248703598976135,
0.278324693441391,
-0.200926274061203,
0.18610362708568573,
-0.2157057523727417,
0.28566670417785645,
-0.3478269875049591,
0.1874369978904724,
-0.28332632780075073,
-0.41747573018074036,
0.06015486270189285,
-0.029844749718904495,
-0.2673271596431732,
0.06615844368934631,
0.8385632634162903,
-0.3883671760559082,
-0.20886726677417755,
0.27026084065437317,
0.5084622502326965,
-0.7485402822494507,
0.3248230516910553,
-0.4530119001865387,
0.07163732498884201,
-0.05280294641852379,
0.04771575704216957,
-0.7149794101715088,
-0.09741583466529846,
-0.6242086291313171,
-0.09653154760599136,
-0.6180427074432373,
-0.10039040446281433,
-0.5001205205917358,
-0.10574142634868622,
0.28181013464927673,
0.35312095284461975,
-0.1487862467765808,
0.7734206914901733,
-0.19395679235458374,
0.4322284162044525,
0.018427077680826187,
0.5840808153152466,
0.9523134827613831,
0.06617294996976852,
0.6615262031555176,
0.3222551643848419,
0.5104741454124451,
1.0336174964904785,
-0.6966943144798279,
-0.6568061113357544,
-0.8967037796974182,
-0.24502597749233246,
-0.029445143416523933,
0.5766887068748474,
-0.48656919598579407,
0.8728537559509277,
-0.3700895309448242,
0.38075128197669983,
-0.10341228544712067,
-0.3524438142776489,
0.06257878243923187,
0.11632660031318665,
-0.06485026329755783,
-0.11934971064329147,
0.34584733843803406,
0.7510552406311035,
-0.12562106549739838,
0.36442676186561584,
0.2934173047542572,
-0.6703065037727356,
-0.007439788430929184,
0.11183764785528183,
-0.036498118191957474,
0.22137610614299774,
0.5925672054290771,
-0.5648762583732605,
-0.6794844269752502,
0.0386265367269516,
0.11155062913894653,
-0.26296207308769226,
-0.18570218980312347,
0.0719604343175888,
0.19509048759937286,
0.13095590472221375,
0.03208165243268013,
-0.007625640835613012,
0.3285458981990814,
-0.12894494831562042,
0.013259783387184143,
-0.313443124294281,
0.11215659976005554,
-0.307808518409729,
0.018633287400007248,
-0.17000292241573334,
0.35007986426353455,
0.10136571526527405,
0.03295157104730606,
-0.06935249269008636,
-0.21709434688091278,
0.20535986125469208,
0.12325150519609451,
-0.7921603918075562,
0.46604248881340027,
0.7476485967636108,
0.275410920381546,
-0.06635167449712753,
-0.462655633687973,
0.33205801248550415,
-0.20933906733989716,
-0.48811498284339905,
-0.23495766520500183,
0.08191795647144318,
0.24025002121925354,
0.24318626523017883,
-0.7956170439720154,
0.04136985167860985,
0.6617156267166138,
-0.10008765012025833,
-0.014070387929677963,
-0.17956043779850006,
-0.0561179555952549,
0.2450447827577591,
0.209448903799057,
-0.5254350900650024,
-0.7653979063034058,
0.17189684510231018,
0.5862232446670532,
-0.017349207773804665,
-0.01736374758183956,
-0.17753882706165314,
0.7029778957366943,
0.4627607762813568,
0.05892731621861458,
-0.6502419710159302,
0.0005810114671476185,
0.06038208305835724,
-0.1517975777387619,
-0.10890205204486847,
0.0004876135499216616,
0.20609882473945618,
-0.014120753854513168,
0.07660302519798279,
0.41319066286087036,
-0.4006415009498596,
-0.07895059883594513,
-0.3792681097984314,
-0.42718759179115295,
0.025275791063904762,
0.24379459023475647,
-0.24706672132015228,
0.204470694065094,
0.057588256895542145,
-0.31971344351768494,
0.14864350855350494,
-0.7349827289581299,
0.09978674352169037,
-0.3664108216762543,
0.039550524204969406,
-0.40214529633522034,
-0.18693336844444275,
0.6583095192909241,
-0.17972779273986816,
0.22470121085643768,
-0.45205166935920715,
-0.2562614381313324,
-0.23807956278324127,
0.2950165569782257,
-0.6854990720748901,
-0.269299179315567,
0.3583659529685974,
-0.06040268391370773,
-0.4597546458244324,
0.4934766888618469,
0.45039868354797363,
-0.7010709047317505,
0.30823129415512085,
-0.3503648042678833,
0.22188220918178558,
0.06110747903585434,
0.18990030884742737,
0.5160406231880188,
-0.07695507258176804,
-0.10824592411518097,
0.13328683376312256,
-0.4781242311000824,
-0.23827598989009857,
0.6978054046630859,
0.1250961273908615,
0.6549453139305115,
-0.41590362787246704,
-0.31441736221313477,
-0.14989665150642395,
-0.5036889910697937,
0.6163195371627808,
-0.2673923075199127,
-0.3346078097820282,
-0.26360851526260376,
-0.10438522696495056,
-0.21958352625370026,
0.007446414325386286,
0.333431601524353,
0.39855825901031494,
-0.7586678862571716,
-0.01108279824256897,
-0.2739235460758209,
-0.09054847061634064,
-0.363328218460083,
-0.18297161161899567,
0.3810593783855438,
-0.17721980810165405,
0.23052939772605896,
0.09346333146095276,
-0.013745438307523727,
-0.8160464763641357,
-0.4883561134338379,
0.17951039969921112,
-0.34069690108299255,
-0.1951935738325119,
0.22147314250469208,
1.154344916343689,
0.5394824147224426,
0.2456655651330948,
0.2381649911403656,
0.18801750242710114,
-0.08407923579216003,
0.21244125068187714,
0.6172209978103638,
0.030361337587237358,
-0.20092755556106567,
0.08290001004934311,
-0.8551542162895203,
0.17886264622211456,
-0.6840977668762207,
0.4279075264930725,
-0.6376424431800842,
-0.10938107222318649,
-0.37539660930633545,
0.2540549039840698,
0.5874338746070862,
-0.45322468876838684,
-0.5716732740402222,
-0.342399537563324,
-0.2850651144981384,
-0.10699627548456192,
-0.0932399109005928,
0.19360145926475525,
-0.08854447305202484,
-1.2012264728546143,
0.36063042283058167,
0.21130825579166412,
-0.13975034654140472,
0.12586812674999237,
-0.07238694280385971,
0.29248422384262085,
0.46672260761260986,
-0.4682080149650574,
0.07151173800230026,
0.14109063148498535,
-0.11464300751686096,
0.1367664933204651,
-0.02826053276658058,
-0.7924517393112183,
0.2868322432041168,
0.1396922916173935,
-0.785318911075592,
0.4318316578865051,
0.08290445804595947,
0.14562970399856567,
0.8397449851036072,
0.13034991919994354,
0.314100980758667,
-0.27722612023353577,
0.42254263162612915,
-0.1832156777381897,
0.34671151638031006,
-0.06432706117630005,
0.7528626918792725,
-0.03852524235844612,
-0.31453827023506165,
-0.21772073209285736,
0.44002318382263184,
0.16289472579956055,
0.0017686702776700258,
0.4498317837715149,
-0.03747157007455826,
-0.42273303866386414,
0.7761392593383789,
0.9248211979866028,
0.14968405663967133,
0.11156833171844482,
-0.034055229276418686,
0.07693152129650116,
0.1718580424785614,
0.0728411003947258,
0.011633398942649364,
0.06742552667856216,
0.41543540358543396,
0.2717864513397217,
-0.1317438781261444,
-0.049314238131046295,
-0.2555743157863617,
-0.3407137095928192,
0.19058312475681305,
-0.20891553163528442,
-0.0720900222659111,
-0.6288254857063293,
-0.07208792120218277,
-0.12002909183502197,
0.3729514479637146,
0.409010648727417,
0.16925373673439026,
-0.6927420496940613,
0.2990819811820984,
0.36313101649284363,
-0.05034831911325455,
-0.21059325337409973,
0.1775233894586563,
0.30133768916130066,
-0.6403626203536987,
-0.2618313729763031,
0.14593905210494995,
-0.28754130005836487,
0.15209631621837616,
0.4069938659667969,
0.8896065950393677,
-0.1630554050207138,
0.5824803709983826,
-0.3954154849052429,
0.14109490811824799,
-0.352914959192276,
-0.5343357920646667,
0.4653210937976837,
-0.28170427680015564,
-0.5309306383132935,
0.27801281213760376,
-0.4500559866428375,
0.18533927202224731,
0.25804147124290466,
-0.440717488527298,
-0.1945825219154358,
0.9751543998718262,
-0.15548981726169586,
-0.3318861722946167,
0.05060397461056709,
0.5215901732444763,
-0.3423941135406494,
0.3035832643508911,
0.7084736227989197,
-0.04263032227754593,
-0.3033550977706909,
0.5600101351737976,
-0.32693180441856384,
0.5465503334999084,
-0.24927495419979095,
0.20518463850021362,
-0.24123582243919373,
-0.13203532993793488,
0.6065438985824585,
1.2329431772232056,
-0.13104502856731415,
0.17652583122253418,
-0.11487408727407455,
-0.03335316851735115,
0.7147878408432007,
-0.4197806417942047,
-0.6019560694694519,
-0.7044605016708374,
0.08572982996702194,
-0.5663597583770752,
0.32658669352531433,
0.09322771430015564,
-0.2463870644569397,
0.3818674087524414,
0.6711221933364868,
0.3366830348968506,
-0.049164388328790665,
0.8482913970947266,
-0.4624844193458557,
-0.04223646968603134,
-0.778750479221344,
0.14612995088100433,
-0.6926933526992798,
0.14568401873111725,
0.6121605634689331,
0.4027107059955597,
-0.10497180372476578,
0.2904943823814392,
0.3704242408275604,
-0.24962039291858673,
0.6514984369277954,
-0.6562056541442871,
0.11657828837633133,
-0.03142791986465454,
0.05096762254834175,
-0.08928631246089935,
-0.63090980052948,
0.5030664801597595,
-0.32226353883743286,
-0.19352062046527863,
-0.04781756550073624,
-0.15946491062641144,
0.19676832854747772,
-0.04990240931510925,
0.10843002051115036,
-0.07867134362459183,
-0.29371127486228943,
-0.08009359985589981
] |
As part of the PLoS Medicine series on Global Health Diplomacy, Lai-Han Chan and colleagues provide a case study of China's growing engagement in global health diplomacy following the SARS epidemic. | [
-0.057243842631578445,
0.024490639567375183,
0.005729573778808117,
0.0362282320857048,
0.013386478647589684,
-0.004653277341276407,
0.01894225738942623,
0.013854632154107094,
-0.02909857966005802,
-0.05863448977470398,
-0.0016139994841068983,
0.023143267259001732,
-0.008808299899101257,
0.00425689946860075,
0.07086780667304993,
-0.020955564454197884,
-0.009287780150771141,
0.03522368520498276,
0.023477183654904366,
-0.024366432800889015,
0.06398599594831467,
0.025803225114941597,
0.014043421484529972,
-0.06607281416654587,
-0.04472433403134346,
0.0029447516426444054,
0.006749396212399006,
0.0053901695646345615,
-0.030797312036156654,
0.040825363248586655,
0.022219078615307808,
0.05297021567821503,
0.01683858036994934,
0.015249591320753098,
-0.019121810793876648,
-0.0021010886412113905,
-0.0018966459902003407,
0.020012663677334785,
0.026679811999201775,
-0.005345779471099377,
0.023306773975491524,
-0.003628957085311413,
-0.0007682652212679386,
0.006974351592361927,
-0.010013166815042496,
0.05047605559229851,
-0.023048147559165955,
0.013274895958602428,
0.016862239688634872,
0.01900695450603962,
0.02436649054288864,
-0.023075291886925697,
-0.015552104450762272,
-0.06589046120643616,
-0.011488553136587143,
-0.02429320104420185,
0.02474142052233219,
-0.0037013699766248465,
0.0013867823872715235,
0.028781000524759293,
-0.021262509748339653,
0.01334065105766058,
-0.028898730874061584,
0.02540990337729454,
0.002605075715109706,
-0.06443783640861511,
-0.012801860459148884,
-0.0008315225131809711,
-0.005145929753780365,
0.02710423618555069,
0.04743298143148422,
0.025242630392313004,
0.0022080657072365284,
0.05363324657082558,
-0.02875412069261074,
0.00908939354121685,
0.0000674803668516688,
0.014250354841351509,
0.036599330604076385,
-0.009602412581443787,
-0.0007740575238130987,
0.0003630774444900453,
-0.05802487954497337,
0.035864491015672684,
0.006942326202988625,
-0.00028048729291185737,
0.0005038052331656218,
-0.005191459786146879,
0.0033821675460785627,
-0.0021625293884426355,
0.041623588651418686,
-0.00007199511310318485,
0.018374834209680557,
-0.012119882740080357,
-0.017441825941205025,
-0.05650116503238678,
0.010742256417870522,
-0.012082181870937347,
0.03950733691453934,
-0.041362617164850235,
0.0020033777691423893,
0.00263175368309021,
0.049469850957393646,
0.03313789144158363,
-0.017403148114681244,
0.004136635456234217,
-0.03339015319943428,
0.01788909174501896,
0.003993354272097349,
0.0059715802781283855,
-0.036013804376125336,
0.03116430714726448,
-0.0010747471824288368,
0.03269648179411888,
0.036271218210458755,
0.0013682577991858125,
-0.0039561414159834385,
0.025620652362704277,
0.037820033729076385,
0.03198031336069107,
0.04989391565322876,
0.0025013915728777647,
0.00008344650268554688,
0.014945239759981632,
-0.006096041761338711,
0.047758329659700394,
0.004762439057230949,
-0.026839500293135643,
-0.06696724146604538,
0.019832391291856766,
-0.010200106538832188,
0.008368792943656445,
0.012389731593430042,
0.044878456741571426,
0.024273263290524483,
-0.013145535252988338,
-0.05820269137620926,
0.032199252396821976,
-0.017788967117667198,
-0.03485701605677605,
-0.04043099656701088,
0.011069263331592083,
-0.0044176471419632435,
0.021850522607564926,
0.0189573522657156,
-0.009051596745848656,
-0.0025582551024854183,
0.017511164769530296,
0.024285055696964264,
0.017720893025398254,
-0.04616742208600044,
-0.004181471187621355,
0.04515297710895538,
-0.03266344964504242,
0.014169354923069477,
0.006290276534855366,
-0.017216578125953674,
-0.015114390291273594,
-0.053840745240449905,
0.025856034830212593,
-0.04857989400625229,
-0.026224670931696892,
-0.021227767691016197,
0.013776754029095173,
0.03861178830265999,
-0.020280083641409874,
-0.0009418312110938132,
-0.03941309079527855,
-0.021748021245002747,
0.007478696759790182,
-0.025086108595132828,
-0.008892524987459183,
-0.0018437540857121348,
0.014961541630327702,
-0.024073051288723946,
-0.015213822945952415,
0.06731799989938736,
0.010979294776916504,
-0.031417977064847946,
0.06511592119932175,
-0.019685562700033188,
-0.024630848318338394,
0.012028122320771217,
-0.026161279529333115,
0.021890362724661827,
0.007051094435155392,
0.0696658045053482,
-0.008106025867164135,
-0.003518052864819765,
0.005615269765257835,
0.0218534916639328,
0.011849239468574524,
-0.004754441790282726,
-0.006726081948727369,
0.007737704087048769,
0.006163379177451134,
0.018464285880327225,
0.02100125327706337,
-0.0034695786889642477,
0.04419177398085594,
-0.062181297689676285,
0.005250492133200169,
0.024291856214404106,
-0.06629082560539246,
0.03123844414949417,
0.04543772339820862,
-0.03455113619565964,
-0.02177450619637966,
-0.004085601773113012,
-0.0027233033906668425,
0.031606461852788925,
0.0022619750816375017,
0.03857498988509178,
-0.01064329594373703,
0.015955161303281784,
0.026313941925764084,
-0.029394282028079033,
0.03719362989068031,
0.01124047115445137,
-0.0271654911339283,
-0.035503510385751724,
-0.014223268255591393,
-0.044311001896858215,
0.040786173194646835,
0.06082532927393913,
0.009163386188447475,
-0.0028987049590796232,
0.019788013771176338,
0.044827233999967575,
0.01827971823513508,
-0.017846932634711266,
0.02732129767537117,
-0.019692974165081978,
-0.025474511086940765,
0.049622904509305954,
-0.01772085763514042,
0.025179196149110794,
-0.040928956121206284,
0.03071102872490883,
-0.019030721858143806,
0.01619531773030758,
-0.032533224672079086,
0.08808952569961548,
0.05520310625433922,
0.04608927294611931,
-0.016493497416377068,
-0.0132406922057271,
0.009551254101097584,
0.036297835409641266,
-0.004511373583227396,
0.01353695522993803,
-0.01749282144010067,
0.022465983405709267,
0.017299681901931763,
0.019675837829709053,
-0.041781872510910034,
-0.04115554317831993,
-0.03804147616028786,
0.031642138957977295,
-0.02630307525396347,
0.0041336314752697945,
0.009124995209276676,
-0.04285162687301636,
-0.0309359859675169,
0.0406528003513813,
0.063117116689682,
-0.010420901700854301,
0.04213264212012291,
-0.022892814129590988,
0.04146965220570564,
0.016640562564134598,
-0.0038524807896465063,
-0.005460912361741066,
-0.08108966052532196,
-0.002424335340037942,
-0.0005748211406171322,
0.03241772949695587,
0.019434690475463867,
-0.04047689214348793,
-0.011442244984209538,
0.006077338941395283,
-0.01531950756907463,
-0.014339271001517773,
0.02417152188718319,
0.013509634882211685,
-0.020640498027205467,
-0.017891546711325645,
0.06663718819618225,
-0.012357301078736782,
0.005448705051094294,
0.0010860064066946507,
-0.044735394418239594,
0.007307920139282942,
-0.03462432697415352,
0.00040573306614533067,
0.009430374950170517,
0.027117855846881866,
0.01178690604865551,
-0.03391673043370247,
-0.01626700349152088,
0.005626919213682413,
-0.0051233707927167416,
0.01938655599951744,
-0.022135505452752113,
-0.015718668699264526,
0.025123294442892075,
-0.024540232494473457,
0.02749788574874401,
-0.025418614968657494,
0.04505928233265877,
0.03895218297839165,
-0.05263176187872887,
-0.03546997159719467,
-0.000033906526368809864,
0.02199559099972248,
0.026083659380674362,
-0.024333909153938293,
-0.010404502041637897,
0.027164699509739876,
-0.004641203675419092,
0.004786156117916107,
0.01523195207118988,
0.011984063312411308,
-0.07539966702461243,
-0.0007967103738337755,
0.0463135726749897,
0.021615976467728615,
-0.007148193661123514,
-0.033626988530159,
-0.0054132672958076,
0.02294989675283432,
-0.016937268897891045,
-0.005286834202706814,
0.013874947093427181,
-0.04935406520962715,
0.03054298460483551,
0.027691515162587166,
-0.014684879221022129,
-0.026394056156277657,
0.00801066029816866,
-0.017086002975702286,
-0.013041667640209198,
0.006794863846153021,
0.014669601805508137,
-0.0041708387434482574,
-0.0022554316092282534,
0.012132449075579643,
0.011221345514059067,
-0.012968108057975769,
-0.037530072033405304,
0.007453519850969315,
0.035701509565114975,
-0.01148347370326519,
-0.04692387580871582,
0.010610722936689854,
0.035903315991163254,
-0.016517965123057365,
0.024410773068666458,
-0.05551561713218689,
0.026801100000739098,
-0.06380697339773178,
0.02985978126525879,
-0.03018070198595524,
0.010860449634492397,
-0.008291427046060562,
0.005068835336714983,
0.012280532158911228,
-0.01542910747230053,
0.008335249498486519,
0.05488636717200279,
-0.030926614999771118,
-0.005336884409189224,
0.015099958516657352,
-0.012309353798627853,
-0.019986893981695175,
-0.016967911273241043,
-0.009393532760441303,
-0.05959923937916756,
0.018423030152916908,
0.0054215495474636555,
-0.05130353197455406,
-0.03518325462937355,
-0.011688211932778358,
-0.03072535991668701,
0.043940719217061996,
0.007083090487867594,
0.024877117946743965,
0.015229368582367897,
0.029301360249519348,
-0.03528331592679024,
-0.01878788322210312,
0.06765180081129074,
0.0010732338996604085,
0.024377871304750443,
-0.0231839120388031,
0.013305160216987133,
-0.023460643365979195,
-0.06338673830032349,
0.0038970422465354204,
-0.021687064319849014,
-0.0009662703378126025,
0.02171340584754944,
0.004237073473632336,
-0.03763426095247269,
0.024255353957414627,
0.0030695286113768816,
-0.027689354494214058,
-0.05144787207245827,
0.028324373066425323,
-0.04234807938337326,
-0.002661649137735367,
0.04044080898165703,
0.020463990047574043,
0.03638799116015434,
0.019252175465226173,
-0.0375572070479393,
0.05410447344183922,
0.016336362808942795,
-0.014796074479818344,
-0.008873873390257359,
0.01165802963078022,
0.0013893508585169911,
0.07278835773468018,
-0.0234324112534523,
-0.038781434297561646,
-0.007269832771271467,
-0.01944229006767273,
0.031615033745765686,
-0.010542161762714386,
0.003714486723765731,
-0.006512979045510292,
-0.03596166521310806,
-0.02776782214641571,
-0.009850443340837955,
0.02057153917849064,
-0.04955306649208069,
0.021712252870202065,
-0.05661448836326599,
-0.001124947564676404,
-0.04373375326395035,
-0.0012425238965079188,
-0.007818003185093403,
0.00667240796610713,
0.005522980820387602,
0.037601202726364136,
0.007684820797294378,
-0.01539942529052496,
-0.02697139047086239,
0.014696364291012287,
0.005161207634955645,
0.03853189945220947,
0.0021782121621072292,
-0.016962416470050812,
-0.02608972229063511,
-0.04677040874958038,
0.011144446209073067,
0.00644207326695323,
-0.006361544597893953,
-0.01563018374145031,
0.022614315152168274,
0.04562987759709358,
-0.021558938547968864,
-0.014389116317033768,
-0.01852346397936344,
0.013808531686663628,
-0.044625505805015564,
-0.0016042444622144103,
-0.013615555129945278,
0.04234384000301361,
0.015000779181718826,
-0.03212279826402664,
-0.04283628612756729,
0.006341258063912392,
-0.020329060032963753,
0.003335261717438698,
-0.046943049877882004,
0.010142172686755657,
-0.01786697842180729,
-0.07070516794919968,
-0.06643203645944595,
0.013730314560234547,
-0.0066091264598071575,
-0.005303742364048958,
-0.0005624038749374449,
-0.03884749114513397,
0.025016414001584053,
-0.08088584989309311,
-0.019103191792964935,
-0.04231814295053482,
0.0307941772043705,
0.024993915110826492,
0.0024269153364002705,
0.018899917602539062,
-0.013270149007439613,
0.053195465356111526,
-0.01671251282095909,
-0.00376576348207891,
-0.03947450593113899,
-0.009602253325283527,
-0.002709059976041317,
-0.034987013787031174,
0.0063004991970956326,
-0.005831191781908274,
-0.07647206634283066,
-0.08073949813842773,
0.012146745808422565,
-0.09048757702112198,
0.01282542198896408,
-0.0033104359172284603,
0.019195832312107086,
-0.02733193151652813,
-0.042325910180807114,
-0.025209859013557434,
0.014629499986767769,
0.008664780296385288,
0.0028716884553432465,
0.028746111318469048,
-0.016448481008410454,
-0.015567929483950138,
0.042694296687841415,
-0.05919938534498215,
0.01345838326960802,
-0.03283664956688881,
0.003727222327142954,
-0.04371087998151779,
-0.021942639723420143,
0.0008325783419422805,
-0.004521011374890804,
-0.03378850594162941,
0.03639563173055649,
0.016465455293655396,
-0.0013233645586296916,
0.014087590388953686,
-0.030050378292798996,
-0.041008394211530685,
-0.01514881756156683,
-0.013751402497291565,
0.02745893970131874,
-0.029861902818083763,
0.048278700560331345,
-0.010654350742697716,
0.024886785075068474,
-0.0024335167836397886,
0.011051797308027744,
0.06673112511634827,
-0.04447983577847481,
0.004302589222788811,
0.036651045083999634,
-0.03694947808980942,
0.01922660507261753,
-0.0008786661201156676,
0.026528095826506615,
0.02754557877779007,
0.010685049928724766,
-0.032381247729063034,
-0.0029030314180999994,
0.022455930709838867,
-0.03661108389496803,
0.029057659208774567,
0.00599504541605711,
-0.005540340673178434,
-0.031199686229228973,
0.018202878534793854,
-0.004174425732344389,
0.01838522031903267,
0.02905280701816082,
0.06974463909864426,
-0.022092821076512337,
0.008698581717908382,
-0.04980281740427017,
0.013229651376605034,
0.002317040227353573,
-0.033943332731723785,
-0.01649314910173416,
-0.004538617562502623,
0.024070149287581444,
-0.03995571658015251,
-0.04021415486931801,
0.06663690507411957,
0.016339609399437904,
-0.009356031194329262,
0.050065264105796814,
0.06809046119451523,
0.013516256585717201,
0.03158652037382126,
0.0010394253768026829,
-0.008396697230637074,
-0.02170063555240631,
-0.053196847438812256,
0.047694187611341476,
0.023507937788963318,
-0.021562965586781502,
-0.016046706587076187,
0.002180104609578848,
0.0001284394966205582,
-0.00739744957536459,
-0.046008266508579254,
-0.06636430323123932,
-0.012918759137392044,
0.018212854862213135,
-0.0022206157445907593,
-0.04721556976437569,
-0.023035632446408272,
0.026786644011735916,
0.017587492242455482,
0.004781289491802454,
0.00564985629171133,
-0.029555432498455048,
0.02891043946146965,
0.01858256570994854,
0.03810647130012512,
0.0020920815877616405,
0.04951735958456993,
-0.023912254720926285,
-0.0116331921890378,
0.047331731766462326,
0.06861283630132675,
-0.00981922261416912,
-0.004543720278888941,
-0.03448575362563133,
-0.00987179670482874,
0.01476692408323288,
0.03459019213914871,
0.02748773992061615,
0.019906211644411087,
0.021951887756586075,
0.020004846155643463,
-0.020652707666158676,
0.007467764429748058,
-0.024820031598210335,
0.002578532323241234,
-0.050808221101760864,
0.04684619605541229,
-0.02936173975467682,
-0.01610107719898224,
0.023111730813980103,
0.012389927171170712,
0.017779827117919922,
0.01415007933974266,
-0.00908538606017828,
0.020862672477960587,
-0.010728143155574799,
0.024253707379102707,
-0.02547021582722664,
0.02274293825030327,
0.019097335636615753,
-0.036550506949424744,
0.0042319162748754025,
0.03914026543498039,
-0.004407981410622597,
0.007395634893327951,
-0.03172273933887482,
0.03969869762659073,
0.02161453664302826,
-0.0015134166460484266,
0.017757631838321686,
0.01372958067804575,
0.004439252894371748,
0.007159652188420296,
0.034966934472322464,
0.010636570863425732,
0.039264973253011703,
0.03176889196038246,
0.014876210130751133,
0.0007962742820382118,
-0.0065056937746703625,
0.008404434658586979,
-0.006916099227964878,
0.028516151010990143,
-0.006594937760382891,
-0.007264700252562761,
-0.003629436017945409,
0.040163204073905945,
-0.04446082189679146,
0.031771011650562286,
-0.02661341056227684,
-0.05668807402253151,
-0.010004670359194279,
-0.02770955301821232,
-0.026474544778466225,
0.05881940945982933,
0.04397653415799141,
-0.014216872863471508,
-0.026576008647680283,
0.0028940499760210514,
-0.028632942587137222,
0.018873175606131554,
-0.00016573861648794264,
-0.027982093393802643,
0.048561662435531616,
-0.05521831288933754,
-0.008294940926134586,
0.008656574413180351,
0.007440970279276371,
0.03931131958961487,
0.013793622143566608,
0.014350853860378265,
0.037076301872730255,
-0.005729789845645428,
-0.003733179997652769,
0.013856062665581703,
0.029938053339719772,
0.03221525251865387,
0.04127133637666702,
-0.01639390178024769,
0.01006638165563345,
-0.026833444833755493,
0.02183593064546585,
0.006237775087356567,
-0.026464048773050308,
0.011659972369670868,
0.005868321750313044,
0.0028901416808366776,
0.01604132540524006,
0.021875828504562378,
-0.0033198168966919184,
0.018143370747566223,
0.017114607617259026,
-0.03235456719994545,
-0.007775084115564823,
-0.01908990740776062,
0.019321627914905548,
0.011804520152509212,
-0.053454045206308365,
0.00898063089698553,
0.02453760802745819,
-0.022632285952568054,
-0.029732799157500267,
-0.031478505581617355,
-0.007259121164679527,
0.045662593096494675,
-0.028352759778499603,
-0.04211102053523064,
-0.033432453870773315,
0.025332989171147346,
-0.021835850551724434,
0.02114449255168438,
-0.008090703748166561,
-0.052607711404561996,
0.030313894152641296,
-0.03153642639517784,
-0.005976198706775904,
0.00693011749535799,
0.015656977891921997,
-0.021067429333925247,
0.016308695077896118,
0.0034823210444301367,
-0.049942001700401306,
-0.001547688734717667,
-0.006220183800905943,
-0.0036005438305437565,
-0.038292597979307175,
-0.01951621286571026,
0.030964381992816925,
0.0161846075206995,
-0.037728436291217804,
0.016965461894869804,
0.01690196990966797,
-0.0224088616669178,
0.011973690241575241,
-0.011707152239978313,
-0.017110805958509445,
0.004782566800713539,
-0.00041200799751095474,
0.007601428776979446,
0.022147594019770622,
-0.021239660680294037,
-0.002184621524065733
] | [
0.1636441946029663,
0.282061368227005,
-0.4529654085636139,
-0.17084726691246033,
-0.26129162311553955,
0.24845203757286072,
-0.1419031023979187,
-0.018346067517995834,
-0.07890158146619797,
-0.2215658724308014,
-0.20055314898490906,
-0.21597206592559814,
0.5842627286911011,
0.10251174122095108,
-0.20938852429389954,
0.41575202345848083,
0.3548930883407593,
0.1529148370027542,
-0.03406136855483055,
-0.25682705640792847,
-0.31606802344322205,
-0.7780800461769104,
0.4073740243911743,
0.36925965547561646,
-0.1497229039669037,
-0.23660704493522644,
0.11691317707300186,
0.08293181657791138,
0.19453677535057068,
-0.19162677228450775,
0.14418058097362518,
0.3117040693759918,
0.010991868562996387,
0.05696277692914009,
-0.4294983446598053,
0.10184790939092636,
-0.12579041719436646,
0.13561904430389404,
0.08009601384401321,
-0.1739305853843689,
-0.2604813873767853,
0.2042437344789505,
-0.01883576065301895,
0.5857786536216736,
0.3732914924621582,
-0.6342167854309082,
-1.7173668146133423,
0.49630388617515564,
-0.646099865436554,
0.16574391722679138,
-0.2927279472351074,
0.3531306982040405,
0.6930884122848511,
-0.04809224605560303,
-0.49194642901420593,
0.48052558302879333,
-0.6186304092407227,
-0.26623594760894775,
0.08547240495681763,
-0.6738120913505554,
0.17107412219047546,
0.07636125385761261,
0.4662339985370636,
-0.2622583508491516,
-0.03299332782626152,
0.26431527733802795,
0.16347791254520416,
0.15668675303459167,
0.16102288663387299,
-0.4595585763454437,
0.26224246621131897,
-0.02936737611889839,
-0.38629674911499023,
0.45002180337905884,
-0.124371737241745,
-0.24679920077323914,
-0.06988589465618134,
-0.20844334363937378,
0.2026483565568924,
0.07981619983911514,
-0.178237184882164,
-0.4372254014015198,
0.05360335856676102,
-0.020847300067543983,
0.03541504591703415,
0.20292064547538757,
0.209397554397583,
0.3037414848804474,
-0.5484830737113953,
0.22181227803230286,
-0.3060666024684906,
-0.039246633648872375,
0.5933525562286377,
0.2952776849269867,
-0.033071111887693405,
0.5585368871688843,
0.7707990407943726,
0.08060814440250397,
0.18718178570270538,
0.028020495548844337,
-0.18227221071720123,
0.014878876507282257,
0.06716470420360565,
-0.27562278509140015,
-0.48526158928871155,
-0.4781285524368286,
-0.5520832538604736,
-0.2807249426841736,
-0.709935188293457,
-0.06387607753276825,
-0.46861931681632996,
0.10393765568733215,
-0.3557736575603485,
0.20247577130794525,
-0.17460016906261444,
0.08320101350545883,
0.15143252909183502,
-0.773944616317749,
-0.3360292613506317,
-0.15718701481819153,
0.06677836924791336,
1.2384932041168213,
-0.38910120725631714,
-0.09282218664884567,
0.08311343193054199,
-0.1892649233341217,
0.0963454619050026,
0.09335459768772125,
0.04910809174180031,
0.7244268655776978,
0.34079232811927795,
0.34467294812202454,
-0.6431671977043152,
-0.15021993219852448,
0.10587206482887268,
-0.2876993715763092,
0.2501222789287567,
0.15372160077095032,
-0.2629612386226654,
0.4541380703449249,
-0.5758876800537109,
-0.409928560256958,
-0.09728984534740448,
-0.13423672318458557,
0.5603047013282776,
0.2749069631099701,
-0.767846405506134,
-0.3770131468772888,
-0.561211109161377,
-0.19936011731624603,
-0.3897077143192291,
-0.1707344502210617,
-0.30067211389541626,
0.08670736104249954,
0.19954879581928253,
1.281949758529663,
0.3299334943294525,
-0.25202396512031555,
0.3589487671852112,
0.21635305881500244,
0.324616938829422,
0.02210639789700508,
-0.33115139603614807,
-0.3279094398021698,
0.2163323163986206,
0.0018511535599827766,
0.21114152669906616,
0.44701331853866577,
-0.33272284269332886,
-0.09505826979875565,
-0.3835125267505646,
-0.16942836344242096,
-0.22133275866508484,
-0.5543743371963501,
0.3207199275493622,
0.35270678997039795,
-0.025422679260373116,
-0.09792351722717285,
-0.12236195057630539,
0.6578997373580933,
-0.6909820437431335,
0.22712109982967377,
0.03299335390329361,
-0.5694958567619324,
0.529434323310852,
-0.050464604049921036,
0.007281421683728695,
0.13367074728012085,
-0.03150082379579544,
0.6440962553024292,
-0.8384113311767578,
-0.7193816900253296,
0.7940354943275452,
-0.07885582745075226,
0.5285718441009521,
-0.22206330299377441,
0.23984599113464355,
1.3416471481323242,
0.12576493620872498,
-0.3807713985443115,
-0.28593751788139343,
-0.04905935749411583,
-0.2606620788574219,
0.3485029339790344,
-0.6153587102890015,
0.5563298463821411,
0.6405370831489563,
-0.008339283987879753,
-0.23495224118232727,
0.17577862739562988,
0.15519781410694122,
0.11916196346282959,
-0.24603386223316193,
-0.1280582696199417,
0.11946834623813629,
-0.16912943124771118,
-0.19177010655403137,
-0.26863884925842285,
-0.37201565504074097,
-0.03886982426047325,
1.0338691473007202,
0.0012441067956387997,
0.7086936235427856,
0.8792108297348022,
0.20285673439502716,
0.5873052477836609,
0.3288077414035797,
0.7228556275367737,
-0.0045838430523872375,
-0.045747917145490646,
0.15784424543380737,
-0.19273099303245544,
0.44934511184692383,
-0.7456708550453186,
-0.11906824260950089,
0.0217178575694561,
-0.05389823764562607,
0.3286360800266266,
0.09684855490922928,
-0.354248970746994,
0.24763643741607666,
0.306780070066452,
-0.3190102279186249,
0.6217387318611145,
-0.14122098684310913,
-0.4022863805294037,
-0.606112003326416,
-0.1388796865940094,
-0.7511261105537415,
-0.3844355344772339,
0.41216686367988586,
0.5249884724617004,
-0.0643986165523529,
0.1862802654504776,
-0.016914449632167816,
-0.2653737962245941,
0.25262245535850525,
-0.16639095544815063,
0.36074402928352356,
-0.2976146340370178,
0.5027683973312378,
0.22732549905776978,
0.156372532248497,
0.14372234046459198,
0.28774532675743103,
-0.38256123661994934,
-0.03926163539290428,
-0.7586566805839539,
0.9155346155166626,
0.09404461830854416,
0.00008571527723688632,
-0.17179720103740692,
-0.5629010200500488,
-0.4365251362323761,
-0.14640210568904877,
-0.5247175097465515,
-0.6106670498847961,
0.5395722389221191,
-0.5643025040626526,
-0.4261131286621094,
0.09033963829278946,
0.5906022787094116,
0.603757381439209,
-0.48468470573425293,
-0.20975865423679352,
-0.2634456157684326,
-0.4133305847644806,
-0.20900596678256989,
-0.07450912892818451,
0.042906105518341064,
0.11829932779073715,
0.20435956120491028,
0.37437430024147034,
-0.16424092650413513,
0.08259785175323486,
0.31698551774024963,
-0.2464599907398224,
0.47215205430984497,
0.3195933699607849,
0.1607828289270401,
-0.2261790782213211,
0.26253634691238403,
0.1144050657749176,
-0.3106594383716583,
0.036006320267915726,
-0.21757203340530396,
-0.34804582595825195,
0.36005470156669617,
-6.113811492919922,
-0.2673206627368927,
0.11856549978256226,
-0.11726692318916321,
-0.14980119466781616,
0.05911438167095184,
1.0738435983657837,
-0.5548557639122009,
0.33774545788764954,
0.04108954593539238,
0.541438102722168,
0.49695369601249695,
0.0915815681219101,
0.040382616221904755,
-0.07158078998327255,
0.676917552947998,
0.10274959355592728,
-0.4212276339530945,
0.6673176288604736,
0.056811053305864334,
-0.07803373038768768,
0.028792520985007286,
-0.2622610330581665,
0.6127609014511108,
0.28455907106399536,
0.14003749191761017,
-0.6831395030021667,
0.5990942716598511,
-0.24180662631988525,
0.17014533281326294,
0.229255810379982,
-0.2840143144130707,
-0.10766855627298355,
0.16698628664016724,
-0.006933778990060091,
-0.02606646530330181,
0.093715600669384,
-0.029737671837210655,
0.22882607579231262,
0.010253089480102062,
-0.20274950563907623,
0.3850230276584625,
-0.580003023147583,
0.07943585515022278,
0.0903659462928772,
-0.28403449058532715,
0.05838346853852272,
0.2050243616104126,
-0.17878937721252441,
0.3564118444919586,
0.19028961658477783,
-0.13233454525470734,
0.5913946032524109,
0.13133805990219116,
-0.17145617306232452,
0.012438612058758736,
-0.14509622752666473,
0.3157714903354645,
-0.42885345220565796,
-0.24673625826835632,
-0.20300686359405518,
-0.49817347526550293,
-0.22386781871318817,
-0.22909417748451233,
0.08172014355659485,
-0.008836600929498672,
-0.14764033257961273,
-0.2625065743923187,
-0.39669883251190186,
-0.5544468760490417,
-0.6237680912017822,
0.5841513276100159,
0.11737291514873505,
-0.9235439300537109,
0.25575491786003113,
-0.8855882287025452,
0.006575028412044048,
0.036817263811826706,
0.053102344274520874,
-0.317131370306015,
-0.3141385018825531,
-0.1345161646604538,
0.24641647934913635,
0.48993179202079773,
0.15773043036460876,
-0.29051172733306885,
0.5497210025787354,
-0.3328821361064911,
-0.18437643349170685,
0.3855512738227844,
-0.18005551397800446,
-0.8371881246566772,
0.1350039392709732,
0.4494788646697998,
0.056275926530361176,
0.6611242890357971,
0.24578692018985748,
0.3138846457004547,
0.128967747092247,
-0.5351020097732544,
0.43846964836120605,
-0.05356297269463539,
-0.6778913736343384,
-0.5622705817222595,
-0.06442026793956757,
-0.04361278936266899,
0.2098318487405777,
0.46930527687072754,
0.5213353633880615,
-0.20315806567668915,
0.14324691891670227,
0.40446144342422485,
-0.21004752814769745,
0.04692584648728371,
0.8662149310112,
-0.1773553490638733,
0.15278120338916779,
0.05056440830230713,
0.6495860815048218,
0.06875719875097275,
0.23526640236377716,
0.15075290203094482,
0.25099503993988037,
0.8309698104858398,
0.3813207745552063,
0.16500630974769592,
-0.2198013812303543,
0.24590899050235748,
-0.8030695915222168,
0.057201530784368515,
0.31009456515312195,
0.25467321276664734,
-0.1021042987704277,
0.12542065978050232,
0.41763460636138916,
-0.4040188789367676,
-0.5152577757835388,
-0.2910667955875397,
-0.17572718858718872,
0.1812775880098343,
-0.05632695183157921,
0.31628698110580444,
-0.25429826974868774,
0.09033253788948059,
-0.13200321793556213,
-0.2122843712568283,
-0.21691328287124634,
0.22435545921325684,
-0.32488492131233215,
0.40455228090286255,
-0.23011021316051483,
-0.25552529096603394,
0.33695849776268005,
-0.12654247879981995,
-0.0636836513876915,
0.07862354069948196,
0.42208045721054077,
0.008020304143428802,
0.05791337415575981,
0.25203800201416016,
0.29204434156417847,
-0.07117075473070145,
-1.1442192792892456,
-0.18499262630939484,
0.10567889362573624,
0.013778597116470337,
0.2664111852645874,
-0.04612177982926369,
-0.3052040636539459,
0.031509075313806534,
0.25012701749801636,
-0.1182117909193039,
-0.32347068190574646,
-0.05995674803853035,
-0.06240781769156456,
-0.2429661601781845,
-0.22655847668647766,
0.3322181701660156,
0.14563427865505219,
0.28532102704048157,
-0.006178255192935467,
-0.23763731122016907,
-0.21679452061653137,
0.07676371186971664,
0.6893984079360962,
0.5229877829551697,
-0.08957303315401077,
-0.7967106103897095,
-0.3911186754703522,
0.3571709990501404,
0.4546101689338684,
0.08275216072797775,
-0.11986856162548065,
0.6446733474731445,
-0.3903719186782837,
-0.3507026433944702,
0.05536746606230736,
-0.8163549304008484,
-0.3156530261039734,
-0.14167720079421997,
-0.15934710204601288,
0.23053796589374542,
-0.3859674334526062,
0.5322297215461731,
0.2541823089122772,
-0.11846515536308289,
-0.10068876296281815,
-0.1015750914812088,
0.18332478404045105,
-0.06485488265752792,
-0.5624579191207886,
-0.481638640165329,
0.35119280219078064,
0.3428392708301544,
-0.0020542042329907417,
-0.16502860188484192,
0.09217723459005356,
-0.47510236501693726,
-0.259325236082077,
0.24272160232067108,
-0.37807366251945496,
-0.288779616355896,
-0.5903248190879822,
-0.774245023727417,
-0.2699662744998932,
0.23816969990730286,
0.26167210936546326,
-0.5669424533843994,
-0.07096712291240692,
-0.1730196326971054,
-0.54188472032547,
-0.17506985366344452,
0.7893039584159851,
0.6037930846214294,
-0.237650066614151,
-0.20256641507148743,
-0.10241052508354187,
-0.016640139743685722,
0.07747852057218552,
-0.05216415598988533,
-0.1152280941605568,
-0.10887037217617035,
-0.23025821149349213,
-0.2474794238805771,
-0.1771688461303711,
0.2855856418609619,
0.11333048343658447,
-0.2650069296360016,
-0.07147388905286789,
-0.3901093602180481,
0.0555524080991745,
-0.28470003604888916,
-0.001031682826578617,
-0.43027883768081665,
0.015778537839651108,
0.06632734835147858,
0.03983309492468834,
-0.24794919788837433,
-0.34600111842155457,
-0.5737397074699402,
-0.262490451335907,
-0.7112210392951965,
0.02558191493153572,
-0.4398806393146515,
-0.19523487985134125,
0.22012893855571747,
0.20126773416996002,
-0.43391016125679016,
-0.5404912233352661,
0.12006403505802155,
-0.42491596937179565,
-0.31531885266304016,
0.2578289210796356,
0.3787287473678589,
0.018403127789497375,
0.34431686997413635,
-0.2278967797756195,
0.006102379411458969,
-0.28649669885635376,
0.4623262286186218,
0.03252803161740303,
-0.30966582894325256,
-0.1956450641155243,
0.10798986256122589,
0.4982370138168335,
-0.19326525926589966,
0.44631925225257874,
0.06720900535583496,
0.44238463044166565,
-0.15966446697711945,
-0.36002111434936523,
-0.004060305189341307,
-0.4101887345314026,
-0.11020797491073608,
0.28101682662963867,
0.4652619957923889,
0.6675951480865479,
-0.0529121533036232,
-0.3032066226005554,
-0.39086318016052246,
-0.5243734121322632,
0.8273945450782776,
0.35881754755973816,
0.057056669145822525,
-0.10192148387432098,
-0.07695598900318146,
-0.0489359088242054,
0.09950646013021469,
-0.20638087391853333,
0.7136414647102356,
0.216456800699234,
0.08552940934896469,
0.34567853808403015,
0.36749067902565,
-0.4473764896392822,
0.17559455335140228,
-0.3760601878166199,
-0.2960152328014374,
0.08572985976934433,
0.05732053518295288,
-0.2583673894405365,
-0.061727214604616165,
0.30781304836273193,
0.18462318181991577,
0.09363892674446106,
0.331462562084198,
0.26803791522979736,
0.1462453007698059,
-0.20027251541614532,
0.9458327293395996,
0.0817694142460823,
1.1746406555175781,
0.016825439408421516,
-0.3032170534133911,
0.2121204137802124,
0.15448692440986633,
0.07958579063415527,
-0.46510520577430725,
0.30738669633865356,
0.2611861228942871,
0.21350468695163727,
0.3196521997451782,
-0.0067811887711286545,
0.014388044364750385,
-0.07542473077774048,
0.15333224833011627,
-0.5360841155052185,
0.8166729807853699,
-0.25612393021583557,
-0.10745320469141006,
0.5336222052574158,
0.7449151873588562,
-0.024382270872592926,
-0.12348926812410355,
0.005783190485090017,
0.23547925055027008,
-0.3630731999874115,
0.021091746166348457,
-0.19409134984016418,
0.26607343554496765,
0.18584030866622925,
-0.08037242293357849,
0.04020536318421364,
0.16511186957359314,
0.3753475546836853,
0.03171674534678459,
0.18880900740623474,
-0.18285444378852844,
-0.08950112015008926,
0.149427592754364,
-0.31542256474494934,
-0.36580318212509155,
0.0655239075422287,
0.37069234251976013,
0.2060956209897995,
-0.7575784921646118,
-0.007430655881762505,
-0.2254672348499298,
-0.0578506775200367,
0.7503385543823242,
-0.060480497777462006,
-0.14517690241336823,
-0.10459192842245102,
-0.24677304923534393,
-0.2945270538330078,
0.6138297915458679,
-0.47865161299705505,
0.43031045794487,
-0.06974375993013382,
-0.09437153488397598,
0.42232954502105713,
-0.1960909366607666,
0.14740905165672302,
0.48760172724723816,
-0.2331492006778717,
0.21351467072963715,
0.2636435925960541,
0.5034868717193604,
0.40291649103164673,
0.41010668873786926,
0.08024124056100845,
-0.02490284852683544,
-0.19026784598827362,
0.6046126484870911,
-0.4316263198852539,
0.3173867166042328,
-0.7875521779060364,
-0.030154423788189888,
-0.8544149398803711,
-0.21589048206806183,
0.23901182413101196,
0.30117267370224,
-0.3645187318325043,
0.04684430733323097,
-0.19405467808246613,
0.7099242210388184,
0.2766296863555908,
-0.0346834734082222,
-0.07314183562994003,
-0.45352494716644287,
-0.5654585361480713,
-0.4218078553676605,
0.4245395362377167,
-0.21250855922698975,
0.1345735341310501,
0.2984662353992462,
-0.14890550076961517,
0.1700829267501831,
0.11473269760608673,
0.5742219686508179,
-0.18473011255264282,
0.005478860344737768,
-0.47711119055747986,
-0.449768990278244,
-0.11537016928195953,
-0.11494646966457367,
0.19748902320861816,
0.16673538088798523,
0.22388972342014313,
-0.18767757713794708,
0.1422855108976364,
0.06285049021244049,
-0.2565497159957886,
0.34560853242874146,
-0.2974024713039398,
0.29661309719085693,
-0.013624661602079868,
-0.2930266261100769,
-0.3603309392929077,
0.4473568797111511,
-0.1294056624174118,
-0.02710404433310032,
0.002310212003067136,
-0.8507660031318665,
0.1581951379776001,
-0.20346757769584656,
0.17909230291843414,
0.008455025032162666,
0.5251908302307129,
-0.5821810960769653
] |
The filoviruses, Marburg and Ebola, are non-segmented negative-strand RNA viruses causing severe hemorrhagic fever with high mortality rates in humans and nonhuman primates. The sequence of events that leads to release of filovirus particles from cells is poorly understood. Two contrasting mechanisms have been proposed, one proceeding via a “submarine-like” budding with the helical nucleocapsid emerging parallel to the plasma membrane, and the other via perpendicular “rocket-like” protrusion. Here we have infected cells with Marburg virus under BSL-4 containment conditions, and reconstructed the sequence of steps in the budding process in three dimensions using electron tomography of plastic-embedded cells. We find that highly infectious filamentous particles are released at early stages in infection. Budding proceeds via lateral association of intracellular nucleocapsid along its whole length with the plasma membrane, followed by rapid envelopment initiated at one end of the nucleocapsid, leading to a protruding intermediate. Scission results in local membrane instability at the rear of the virus. After prolonged infection, increased vesiculation of the plasma membrane correlates with changes in shape and infectivity of released viruses. Our observations demonstrate a cellular determinant of virus shape. They reconcile the contrasting models of filovirus budding and allow us to describe the sequence of events taking place during budding and release of Marburg virus. We propose that this represents a general sequence of events also followed by other filamentous and rod-shaped viruses. | [
-0.007963537238538265,
0.022384051233530045,
0.005250079557299614,
0.008669625967741013,
-0.014149008318781853,
-0.01653921976685524,
0.007144682575017214,
0.030576545745134354,
-0.012406268157064915,
-0.0029247947968542576,
-0.013075822032988071,
0.015350950881838799,
-0.0012524455087259412,
0.008340753614902496,
0.00939076580107212,
-0.013259419240057468,
0.0016114499885588884,
0.0005956252571195364,
0.006956668570637703,
0.015217243693768978,
0.020784862339496613,
-0.018112337216734886,
0.008823412470519543,
-0.0026281641330569983,
-0.027935348451137543,
0.010628028772771358,
-0.013789743185043335,
-0.010523059405386448,
0.005121390800923109,
0.02615855447947979,
0.015660082921385765,
-0.008150564506649971,
0.0012386699672788382,
-0.0015031248331069946,
0.012739998288452625,
0.018057983368635178,
-0.001436494174413383,
0.02576405182480812,
-0.005731636192649603,
-0.0038034708704799414,
0.010027014650404453,
-0.0032995797228068113,
0.005685041658580303,
-0.002952913288027048,
-0.008331384509801865,
-0.0015974338166415691,
0.00022154947509989142,
0.009920628741383553,
-0.017751161009073257,
0.001695986371487379,
-0.006032225675880909,
0.006025784183293581,
-0.0037772338837385178,
0.013120097108185291,
-0.005214752163738012,
0.007250956725329161,
0.01726919412612915,
0.0028814533725380898,
-0.011982422322034836,
0.005932420492172241,
0.00772627629339695,
0.010057481937110424,
-0.0142432302236557,
0.013994503766298294,
0.010703293606638908,
-0.06721793860197067,
0.008867161348462105,
0.0176442451775074,
0.009260548278689384,
0.003489087335765362,
0.0016272584907710552,
-0.0015618526376783848,
0.010462374426424503,
0.006682206876575947,
-0.004134564660489559,
-0.0004171188920736313,
-0.013735931366682053,
0.01524631679058075,
-0.020966947078704834,
0.005860915407538414,
0.01585138402879238,
-0.01227790117263794,
0.013656852766871452,
0.00738701643422246,
-0.016534432768821716,
0.01384657807648182,
-0.012877210974693298,
0.0127480523660779,
0.0032329943496733904,
0.008527141995728016,
0.004652186296880245,
0.007951676845550537,
-0.022707542404532433,
0.027843909338116646,
-0.0012536942958831787,
-0.00799595844000578,
-0.009621093049645424,
-0.00587322236970067,
-0.005591042339801788,
0.0016779867000877857,
-0.013811582699418068,
0.014240124262869358,
0.011456044390797615,
0.004771038889884949,
0.0012696050107479095,
0.008550604805350304,
0.00479694502428174,
0.009103010408580303,
0.008979997597634792,
0.008693039417266846,
0.002475423039868474,
-0.01240595243871212,
0.0007059727795422077,
0.0058306255377829075,
-0.029187511652708054,
-0.013345472514629364,
-0.0028380551375448704,
0.01585545390844345,
-0.0020916007924824953,
0.004498815163969994,
0.03373205289244652,
0.000018680468201637268,
0.004317892715334892,
0.0008055579382926226,
0.006708569824695587,
-0.03123725950717926,
0.015008498914539814,
-0.02184060588479042,
0.028866982087492943,
0.002387873362749815,
-0.0067403074353933334,
0.005791487172245979,
-0.01287984661757946,
-0.017108773812651634,
0.0013864007778465748,
0.004570392891764641,
0.003983278293162584,
-0.012267494574189186,
0.01715889945626259,
-0.027445100247859955,
-0.013755704276263714,
0.005074735730886459,
0.002559659769758582,
0.00982522964477539,
0.02118018828332424,
0.003789320355281234,
-0.014320965856313705,
0.018469590693712234,
0.00084865209646523,
0.007311354391276836,
0.022100791335105896,
0.007995001040399075,
-0.0028016373980790377,
0.00017638131976127625,
0.021508092060685158,
0.004959925543516874,
-0.012682052329182625,
-0.012772979214787483,
-0.0017510069301351905,
0.013161747716367245,
-0.009472185745835304,
-0.006587624549865723,
0.0012626808602362871,
0.008376887999475002,
0.010707741603255272,
0.005007463973015547,
0.021684084087610245,
-0.018826492130756378,
0.012129763141274452,
0.005408995319157839,
-0.0004777825088240206,
0.005996151827275753,
-0.0033742450177669525,
0.00891018845140934,
0.015992403030395508,
0.0031475620344281197,
0.008746333420276642,
0.004998394753783941,
-0.007924063131213188,
0.06652398407459259,
0.002694223076105118,
0.03760823979973793,
0.00987384282052517,
-0.020232034847140312,
0.014431210234761238,
-0.011456730775535107,
-0.018190287053585052,
-0.00997968576848507,
0.0006354821380227804,
0.006797458976507187,
0.00935925543308258,
-0.009116258472204208,
-0.011555593460798264,
-0.01719629392027855,
0.0043791718780994415,
0.002454690635204315,
0.0040803574956953526,
0.006421140395104885,
0.01213446632027626,
0.001865697093307972,
0.00621376559138298,
0.013465026393532753,
0.023117762058973312,
0.020470324903726578,
-0.029210584238171577,
0.002830452984198928,
-0.005840310361236334,
-0.02032827027142048,
0.01351957581937313,
-0.016674185171723366,
-0.0057743689976632595,
0.015860874205827713,
0.0013608543667942286,
-0.013672200962901115,
0.018202098086476326,
-0.010357733815908432,
-0.010429929941892624,
0.005168660543859005,
0.0018807784654200077,
-0.01302754133939743,
-0.005547534208744764,
0.005657956935465336,
-0.026763632893562317,
0.009429707191884518,
-0.00324612925760448,
-0.021877191960811615,
-0.001327477628365159,
0.007176622282713652,
0.0016511714784428477,
0.0002768265549093485,
-0.012566512450575829,
-0.014339263550937176,
-0.008538922294974327,
0.014991684816777706,
0.006390854716300964,
-0.015130652114748955,
0.011343147605657578,
-0.026222756132483482,
0.017259564250707626,
-0.013313280418515205,
0.0012355258222669363,
-0.003123512491583824,
0.00857690442353487,
-0.011163700371980667,
-0.02356044389307499,
-0.009916448965668678,
0.024387642741203308,
0.010325348936021328,
0.008050491102039814,
-0.0068795764818787575,
0.005629383027553558,
-0.006448717322200537,
0.019613731652498245,
-0.031262315809726715,
0.025272494181990623,
-0.005621898919343948,
0.018250636756420135,
-0.0023111836053431034,
0.023415107280015945,
0.01806839555501938,
0.007544703781604767,
0.004557596519589424,
0.006172926165163517,
0.0033592304680496454,
0.01092837005853653,
-0.001677490770816803,
-0.015634648501873016,
-0.00505767110735178,
0.0025245007127523422,
0.006076225079596043,
0.005998706445097923,
-0.008662156760692596,
0.001607342273928225,
-0.08178146183490753,
-0.01079535111784935,
0.014395641162991524,
-0.0009745454881340265,
0.004623278975486755,
-0.0024433298967778683,
-0.004154096823185682,
-0.0094624487683177,
-0.00975341722369194,
-0.012827228754758835,
-0.005847344174981117,
0.010989786125719547,
0.000956153788138181,
-0.039463866502046585,
0.018142201006412506,
-0.0018311003223061562,
0.0117304977029562,
-0.0030609399545937777,
-0.01932133175432682,
-0.022427525371313095,
-0.01908930204808712,
0.010913831181824207,
0.01690308377146721,
-0.001366149983368814,
-0.005447723902761936,
0.0089170653373003,
0.024162277579307556,
0.020436739549040794,
0.009965835139155388,
0.01690581813454628,
-0.002847769297659397,
-0.017279746010899544,
0.020157694816589355,
0.00037865759804844856,
0.01874890737235546,
0.004303915426135063,
0.006383839994668961,
-0.016433704644441605,
-0.005091900005936623,
-0.005277750547975302,
-0.016239088028669357,
0.02016269415616989,
0.008787930943071842,
0.0066215479746460915,
0.004266571253538132,
0.008144735358655453,
-0.006455039605498314,
-0.000025055604055523872,
0.012966275215148926,
-0.010720846243202686,
-0.0007245359010994434,
-0.006819140166044235,
0.019962437450885773,
0.016037721186876297,
-0.0064175985753536224,
0.0206136517226696,
-0.012563171796500683,
0.012247445061802864,
-0.00766426557675004,
-0.005344211123883724,
0.01592974178493023,
-0.0007146131247282028,
-0.0026342286728322506,
0.007445291616022587,
-0.03600187227129936,
0.021367326378822327,
0.025969721376895905,
0.01931459829211235,
-0.007887513376772404,
0.012763469479978085,
-0.010038471780717373,
-0.00044697237899526954,
0.018087994307279587,
-0.0040465001948177814,
-0.0050057778134942055,
-0.003429541364312172,
-0.009247815236449242,
-0.01511595118790865,
-0.008273588493466377,
-0.021884381771087646,
-0.03235075995326042,
0.0030567266512662172,
-0.02825133502483368,
0.016226250678300858,
-0.01469501480460167,
0.011688154190778732,
0.003953900188207626,
0.015154033899307251,
0.0037337096873670816,
-0.023078598082065582,
0.03327468782663345,
-0.025928178802132607,
-0.02524566650390625,
0.01056471187621355,
-0.01344482321292162,
-0.01853885129094124,
-0.005533124785870314,
-0.003459556959569454,
0.005946682766079903,
0.007198205683380365,
-0.01735713705420494,
0.0049612075090408325,
-0.02281828597187996,
-0.005225099623203278,
-0.014754515141248703,
0.015280937775969505,
0.013362163677811623,
-0.00972793623805046,
0.0008772590663284063,
-0.004868515767157078,
-0.0022015287540853024,
0.023816896602511406,
-0.0029737940058112144,
0.012883422896265984,
0.012033224105834961,
-0.00035594869405031204,
-0.010403992608189583,
-0.0006993822753429413,
0.07275903970003128,
0.012677403166890144,
0.0020000364165753126,
-0.0028296816162765026,
0.01795670948922634,
-0.01758493110537529,
0.001597969327121973,
0.006016666069626808,
-0.022228244692087173,
-0.016542896628379822,
0.011056136339902878,
-0.011230369098484516,
0.008444299921393394,
0.012236569076776505,
-0.004161857068538666,
-0.015291653573513031,
0.012503325939178467,
-0.030167747288942337,
0.0358876995742321,
0.009584483690559864,
0.010967914015054703,
-0.0032345233485102654,
0.00004624819848686457,
0.010980755090713501,
0.020763535052537918,
-0.0014916094951331615,
0.009968118742108345,
-0.012337244115769863,
-0.012108909897506237,
0.004946553148329258,
-0.009435731917619705,
0.007702996022999287,
-0.00709816487506032,
0.0030048873741179705,
0.02407994121313095,
0.0030607557855546474,
-0.011766149662435055,
0.013503888621926308,
0.003711097175255418,
-0.004094115924090147,
-0.012150001712143421,
-0.009311111643910408,
-0.0026257908903062344,
0.011984400451183319,
-0.009208975359797478,
-0.014671005308628082,
-0.0003049238584935665,
-0.005850187502801418,
-0.0077524688094854355,
-0.0027487429324537516,
0.004085148684680462,
-0.004429062828421593,
0.010005218908190727,
0.007472728379070759,
0.001203758642077446,
-0.008646050468087196,
0.011544471606612206,
-0.000044015818275511265,
0.010780097916722298,
-0.0037412347737699747,
-0.005609593819826841,
0.014612874947488308,
0.005811343900859356,
-0.015040118247270584,
0.005898052826523781,
-0.01188279315829277,
-0.005215231794863939,
0.005569850094616413,
-0.015787754207849503,
-0.015040555037558079,
0.017436854541301727,
-0.005901356693357229,
0.0059677851386368275,
0.0071753161028027534,
-0.014642952010035515,
-0.031707655638456345,
-0.001270147506147623,
-0.026211947202682495,
0.012833567336201668,
0.0009907539933919907,
0.030231036245822906,
-0.022205276414752007,
-0.0015546418726444244,
-0.011667589657008648,
-0.030333414673805237,
-0.02995019033551216,
-0.007425633259117603,
-0.07483265548944473,
-0.006347328424453735,
-0.011889908462762833,
-0.0006216865149326622,
-0.00892600603401661,
0.018380997702479362,
-0.012062320485711098,
0.019736398011446,
-0.00829404965043068,
-0.0020769466646015644,
-0.0199336726218462,
0.007950816303491592,
0.0021321866661310196,
0.008562685921788216,
0.011491196230053902,
-0.009568450041115284,
-0.00045262405183166265,
0.005751586053520441,
-0.008475114591419697,
-0.006032295059412718,
0.028420165181159973,
-0.01597673073410988,
-0.020377719774842262,
0.003635549684986472,
-0.004941823426634073,
-0.0816822201013565,
-0.018151365220546722,
0.0012285482371225953,
-0.0022869277745485306,
0.001793696079403162,
-0.00866550114005804,
-0.011678071692585945,
-0.01564769819378853,
0.009258798323571682,
-0.015750214457511902,
-0.02831585519015789,
-0.0009090700186789036,
0.015251021832227707,
-0.005020447075366974,
0.011843913234770298,
-0.009990911930799484,
-0.01014665700495243,
0.01574755646288395,
0.00853799469769001,
0.0005598886637017131,
-0.0024188875686377287,
0.007617626339197159,
-0.007123682647943497,
-0.013550054281949997,
-0.009497815743088722,
-0.006613998208194971,
-0.01498270221054554,
0.00606171227991581,
0.018793858587741852,
0.02281622588634491,
-0.027095165103673935,
-0.003237418830394745,
0.016956916078925133,
-0.009868395514786243,
0.01441730186343193,
-0.0027597774751484394,
0.012244011275470257,
0.0011991956271231174,
-0.005303179379552603,
-0.004041527863591909,
-0.005879594013094902,
-0.006209792569279671,
0.031056977808475494,
0.015430103056132793,
0.009820787236094475,
-0.011422869749367237,
0.004682502709329128,
-0.008599177934229374,
0.029213327914476395,
-0.02632822096347809,
0.009612781926989555,
0.006952677853405476,
-0.0037750492338091135,
0.0038399100303649902,
-0.010321972891688347,
-0.008684679865837097,
-0.004529024474322796,
0.011370067484676838,
0.02104089967906475,
0.016265619546175003,
0.008155426010489464,
0.00502416118979454,
0.0015771943144500256,
0.07176239788532257,
-0.009909320622682571,
0.01308555155992508,
0.009215856902301311,
-0.0015173594001680613,
0.00522247888147831,
-0.020497392863035202,
-0.008776198141276836,
-0.0034217373467981815,
-0.021983880549669266,
-0.006576180458068848,
0.00004713021917268634,
-0.005987537559121847,
0.00885110255330801,
0.012962540611624718,
-0.012114143930375576,
-0.008211120031774044,
0.006473962217569351,
-0.008900737389922142,
0.009664851240813732,
-0.0022781938314437866,
-0.011691335588693619,
-0.030032102018594742,
-0.027507977560162544,
0.0009410205530002713,
0.004914569668471813,
-0.026527658104896545,
0.03761113062500954,
-0.00035592028871178627,
-0.006393207237124443,
-0.014435727149248123,
-0.009294644929468632,
0.00016785762272775173,
-0.008092326112091541,
0.008668145164847374,
-0.004235247150063515,
-0.021370310336351395,
0.008227999322116375,
-0.012900843285024166,
0.0039399839006364346,
-0.009957442060112953,
0.012976903468370438,
-0.00662601413205266,
-0.023000720888376236,
-0.014461301267147064,
-0.017737867310643196,
0.006817921996116638,
0.013518664985895157,
0.002464023884385824,
0.012712910771369934,
-0.008764313533902168,
0.004018832463771105,
0.021782543510198593,
0.023067740723490715,
-0.0005132067017257214,
0.015295300632715225,
-0.020545918494462967,
0.017182521522045135,
-0.013311441987752914,
-0.00532655231654644,
-0.004719164222478867,
-0.010851042345166206,
-0.00121205672621727,
-0.017903689295053482,
0.01098231878131628,
0.0001279423013329506,
-0.006186739541590214,
-0.01749027706682682,
-0.010072322562336922,
0.012804729864001274,
-0.010054752230644226,
0.0008437600918114185,
0.004970140289515257,
-0.007710455916821957,
0.0056373318657279015,
0.008470093831419945,
0.05452664569020271,
0.001187794143334031,
0.02304505929350853,
0.009361304342746735,
-0.00007933255983516574,
-0.0017237223219126463,
0.035888757556676865,
0.004356957972049713,
-0.016083572059869766,
0.0029571910854429007,
0.002791220787912607,
0.009384212084114552,
-0.005240471102297306,
0.00016046140808612108,
0.014747237786650658,
-0.008565837517380714,
-0.00014807377010583878,
-0.0036988959182053804,
0.009321032091975212,
0.03371093422174454,
-0.003856776049360633,
0.005273986607789993,
0.020965468138456345,
-0.0015397160314023495,
-0.015634236857295036,
-0.0170632041990757,
-0.011079778894782066,
0.007977202534675598,
-0.0029076477512717247,
-0.0036225351504981518,
0.00764726847410202,
0.0199658814817667,
-0.007231779396533966,
0.005494660697877407,
0.01270357333123684,
0.006793651729822159,
0.027385514229536057,
0.0004065241664648056,
0.010698894038796425,
-0.012017223984003067,
-0.012933002784848213,
-0.00852270983159542,
0.01604137383401394,
-0.00940349604934454,
0.006127357482910156,
0.010840045288205147,
-0.0032683038152754307,
0.004548949189484119,
-0.02115519903600216,
0.002868768759071827,
-0.004467715043574572,
0.002499643247574568,
-0.004820909816771746,
0.007142947055399418,
-0.0002507626486476511,
0.00876983068883419,
-0.0018783328123390675,
-0.0007048561237752438,
-0.015459776856005192,
0.0030677965842187405,
0.018223144114017487,
0.021769803017377853,
0.0037084193900227547,
-0.01804395392537117,
0.014668329618871212,
-0.018634583801031113,
-0.0024022841826081276,
-0.016113992780447006,
0.007262811996042728,
-0.001089467667043209,
0.0012765279971063137,
-0.010092945769429207,
0.01778360828757286,
0.0036977240815758705,
-0.0004884791560471058,
0.014507722109556198,
0.005785196088254452,
-0.01004431676119566,
0.00284768408164382,
-0.005812818184494972,
0.0067674946039915085,
0.006828955374658108,
0.02162855677306652,
-0.0012682259548455477,
0.008560980670154095,
0.029886968433856964,
-0.00018769013695418835,
0.0019417887087911367,
-0.007964287884533405,
0.016867641359567642,
0.014895845204591751,
0.025924161076545715,
-0.013037808239459991,
0.011960508301854134,
-0.004495707340538502,
-0.023903504014015198,
0.014727776870131493,
-0.011683601886034012,
0.0034666028805077076,
-0.014671331271529198,
0.0014562427531927824,
-0.008492392487823963,
-0.015970271080732346,
0.010556255467236042,
0.008847002871334553,
-0.013426130637526512,
0.011545917019248009,
-0.006323949433863163,
-0.015759602189064026,
0.006510947365313768,
-0.0036712060682475567,
0.017331887036561966,
0.001098777400329709,
-0.005870093125849962,
-0.0022009725216776133,
-0.0015579527243971825,
-0.003924742341041565,
0.01839628629386425,
0.005445287562906742,
-0.016282174736261368,
-0.01820450648665428,
-0.03340885043144226,
0.00532344076782465,
0.013811971992254257,
-0.0050407820381224155,
0.002821501577273011
] | [
-0.022243952378630638,
-0.09694978594779968,
0.4393095076084137,
-0.0015927207423374057,
0.276218980550766,
-0.18805642426013947,
0.3071724474430084,
0.41634371876716614,
-0.1785307079553604,
-0.2992497384548187,
-0.007815871387720108,
-0.21409490704536438,
-0.8336175680160522,
0.5334545969963074,
0.2308129370212555,
0.3467867374420166,
0.28663820028305054,
0.359614759683609,
-0.6306999921798706,
-0.13674981892108917,
-0.3765079081058502,
-0.3902025818824768,
0.17708159983158112,
0.27638569474220276,
0.0034601488150656223,
-0.4211123585700989,
0.4537751078605652,
0.13078129291534424,
0.6377924084663391,
-0.4456655979156494,
0.3608722388744354,
0.5125722885131836,
0.11306344717741013,
-0.04053381085395813,
-0.004366706591099501,
-0.22981739044189453,
-0.600917398929596,
-0.02867657132446766,
0.02773764543235302,
-0.5504683256149292,
-0.23641632497310638,
0.0019848812371492386,
-0.425974577665329,
0.17189209163188934,
0.018423505127429962,
-0.5814430117607117,
-1.1189303398132324,
0.7729750871658325,
-0.31992843747138977,
0.39425089955329895,
-0.09362352639436722,
0.07849197834730148,
-0.061973392963409424,
0.072555772960186,
0.19271211326122284,
-0.009895170107483864,
-0.4317207336425781,
-0.26067450642585754,
0.40631499886512756,
-0.5077129006385803,
0.43210798501968384,
-0.3247933089733124,
-0.0024184698704630136,
0.47048839926719666,
-0.23835083842277527,
0.6621837615966797,
0.05995936691761017,
0.023894604295492172,
-0.34505903720855713,
-0.4223683774471283,
-0.14776374399662018,
-0.5302790999412537,
-0.2906234562397003,
0.001001440454274416,
0.13844797015190125,
-0.2204112857580185,
-0.4086493253707886,
-0.4266606271266937,
0.25974082946777344,
0.36547788977622986,
-0.3853945732116699,
0.022532347589731216,
0.13757610321044922,
-0.2287348508834839,
0.3092927932739258,
0.15791055560112,
-0.015384167432785034,
0.5289391279220581,
-0.11492043733596802,
0.20578789710998535,
-0.11032585799694061,
-0.003237833036109805,
0.5334698557853699,
0.1775766909122467,
0.1847674399614334,
-0.010095145553350449,
0.09457466006278992,
0.06855893135070801,
0.19576427340507507,
0.3258669674396515,
-0.43828991055488586,
-0.1877882182598114,
-0.3832661509513855,
-0.3667292296886444,
-0.2139550894498825,
-0.0038174560759216547,
-0.24263201653957367,
-0.613969624042511,
-0.30437159538269043,
-0.03134864568710327,
-0.6225722432136536,
-0.4205830991268158,
-0.10469967126846313,
-0.327011376619339,
-0.44086530804634094,
-0.11225128918886185,
0.26866576075553894,
-0.9639079570770264,
-0.0974518433213234,
-0.1930411159992218,
-0.48289960622787476,
0.7998312711715698,
-0.17098502814769745,
0.09780841320753098,
0.350542813539505,
-0.29698407649993896,
-0.2816760241985321,
-0.14824260771274567,
-0.5694178342819214,
0.9137563109397888,
0.28716763854026794,
0.809255063533783,
-0.23790685832500458,
0.02301032654941082,
-0.06331686675548553,
0.03661150485277176,
-0.5727217197418213,
0.46589136123657227,
0.1583636850118637,
-0.3469107747077942,
-0.6263359785079956,
-0.4342987537384033,
-0.5767776966094971,
0.38153064250946045,
0.09710682928562164,
-0.15892012417316437,
-0.782041072845459,
-0.08812088519334793,
-0.28544479608535767,
-0.6559087634086609,
-0.16744913160800934,
-0.4040980339050293,
-0.19597624242305756,
-0.04292004927992821,
0.10747608542442322,
0.19753003120422363,
0.19000884890556335,
-0.13120006024837494,
0.04909321665763855,
0.21238955855369568,
0.2223358154296875,
0.10722167044878006,
-0.11249066144227982,
-0.11907567083835602,
0.07441557943820953,
0.25107938051223755,
0.42118561267852783,
0.6077220439910889,
-0.021110573783516884,
-0.023972174152731895,
-0.17062506079673767,
-0.21848799288272858,
0.4183812439441681,
-0.44003841280937195,
0.13831232488155365,
-0.025457294657826424,
0.30879276990890503,
-0.13787327706813812,
0.28824925422668457,
-0.05303520709276199,
-0.3973701298236847,
0.2588297426700592,
-0.23439909517765045,
-0.12280736863613129,
-0.2723398506641388,
0.1999131441116333,
-0.27506786584854126,
-0.066505566239357,
0.022213825955986977,
-0.016887325793504715,
-0.16005197167396545,
-0.26161468029022217,
0.5145474076271057,
-0.13629046082496643,
1.1999211311340332,
-0.3162742853164673,
-0.1518288254737854,
0.9999779462814331,
0.18274269998073578,
-0.18737617135047913,
-0.34586355090141296,
0.21175359189510345,
0.2599799931049347,
-0.1336652785539627,
-0.7505901455879211,
0.4068922996520996,
-0.02233108878135681,
-0.17877911031246185,
0.2979724407196045,
0.231689915060997,
0.7304951548576355,
-0.13368579745292664,
-0.08430276811122894,
-0.42202460765838623,
0.688815712928772,
-0.07138116657733917,
-0.22801357507705688,
-0.3491332232952118,
-0.2030884176492691,
-0.2653968334197998,
0.2914050817489624,
-0.9038950800895691,
0.3423219919204712,
0.6234265565872192,
0.09271052479743958,
0.5300970077514648,
0.4139358401298523,
0.11487021297216415,
0.9904569983482361,
-0.5494899749755859,
0.48339733481407166,
-0.2890982925891876,
0.7830672860145569,
-0.35989826917648315,
-0.3038405776023865,
0.009681040421128273,
0.18248291313648224,
-0.06263205409049988,
0.2452622354030609,
-0.16186785697937012,
0.455177903175354,
0.6892603039741516,
-0.6255789995193481,
0.07284422963857651,
0.13106371462345123,
-0.5924312472343445,
-0.27896758913993835,
-0.30886149406433105,
-0.7112243175506592,
-0.17703844606876373,
0.31818369030952454,
0.5697796940803528,
0.2595515847206116,
-0.2507205009460449,
0.7522777915000916,
0.09359046816825867,
0.04047491401433945,
0.25593698024749756,
0.594273567199707,
-0.1283097267150879,
-0.4107170104980469,
0.03309681639075279,
-0.1696755588054657,
0.4323410391807556,
-0.18346665799617767,
0.09219454228878021,
-0.4021982252597809,
-0.4139813482761383,
0.44094929099082947,
0.912287712097168,
0.6803798079490662,
0.29061952233314514,
-0.7828245759010315,
-0.05893794819712639,
0.34597036242485046,
-0.7138100266456604,
0.6355254054069519,
0.6119943857192993,
-0.09643193334341049,
-0.1332709789276123,
-0.5660742521286011,
0.052847523242235184,
0.819948136806488,
-0.7037432789802551,
0.022110063582658768,
-0.43421241641044617,
-0.1134691834449768,
-0.04211029037833214,
-0.3159846067428589,
-0.1806783676147461,
-0.5575498938560486,
0.2216293215751648,
-0.2029978334903717,
0.4491490423679352,
-0.4034994840621948,
0.3150861859321594,
-0.011965333484113216,
0.4325839877128601,
0.4831155836582184,
-0.2855965793132782,
-0.20392853021621704,
0.08922049403190613,
-0.24851377308368683,
0.040829405188560486,
-0.17495311796665192,
0.22785811126232147,
-0.3026721775531769,
0.33102115988731384,
-5.958855152130127,
0.19870200753211975,
-0.2941727936267853,
-0.12634751200675964,
0.017026767134666443,
0.10625974833965302,
1.1362966299057007,
-0.024127617478370667,
0.3185593783855438,
0.04817553982138634,
0.8140615820884705,
0.442704439163208,
0.0035328336525708437,
-0.4599752724170685,
-0.36290958523750305,
0.14089348912239075,
-0.5543401837348938,
-0.3398602604866028,
0.3579608201980591,
-0.00203274586237967,
-0.012990192510187626,
-0.018259214237332344,
-0.03051270917057991,
0.46126919984817505,
-0.1837480217218399,
0.2666332423686981,
-0.6039084792137146,
0.19036920368671417,
-0.20440369844436646,
0.5376455783843994,
-0.2632027864456177,
-1.0135856866836548,
-0.00657260324805975,
-0.32183077931404114,
0.02936701476573944,
-0.24615831673145294,
0.19960257411003113,
-0.27803361415863037,
-0.17692357301712036,
-0.05069540813565254,
0.012423938140273094,
0.3161650002002716,
-0.13170014321804047,
-0.16561977565288544,
-0.05268378555774689,
-0.38273724913597107,
0.06939784437417984,
0.37555214762687683,
-0.30919790267944336,
0.8543499112129211,
0.12400716543197632,
-0.03402562066912651,
0.08845078200101852,
0.7705827951431274,
0.6229074001312256,
0.2173510640859604,
0.2152489274740219,
-0.04667935147881508,
0.06221892684698105,
-0.405097097158432,
-0.17220918834209442,
-0.0157488826662302,
-0.464232861995697,
-0.21594847738742828,
0.5197728276252747,
-0.08089151978492737,
-0.4616451859474182,
0.062045060098171234,
0.5810126066207886,
-0.41100919246673584,
-0.39787542819976807,
-0.42291006445884705,
0.04634226858615875,
-0.8936349749565125,
0.4303606450557709,
-0.5968305468559265,
-0.03331228345632553,
-0.20599764585494995,
0.10347548127174377,
-0.46157732605934143,
-0.4915611445903778,
-0.17047090828418732,
-0.32029440999031067,
-0.27223074436187744,
0.3436075448989868,
-0.8862366676330566,
-0.27173763513565063,
-0.30578550696372986,
-0.03709910064935684,
-0.12379180639982224,
0.4148479104042053,
-0.15680459141731262,
0.10403917729854584,
0.32687363028526306,
0.24344509840011597,
0.6835247874259949,
-0.08266361057758331,
0.8514369130134583,
0.5582045912742615,
0.15721195936203003,
1.0867383480072021,
-0.31888526678085327,
-0.7205812335014343,
-0.9405004382133484,
0.010995149612426758,
0.4516614079475403,
-0.35758358240127563,
0.12716269493103027,
0.49579092860221863,
-0.6316424012184143,
0.10737115144729614,
0.31039008498191833,
-0.13989616930484772,
-0.5861539840698242,
0.44521814584732056,
-0.21332859992980957,
0.26940542459487915,
0.8698611855506897,
0.6700600981712341,
-0.13215647637844086,
0.2657619118690491,
0.6405684351921082,
-0.6353084444999695,
0.3376758396625519,
0.3005325496196747,
0.30105680227279663,
-0.08596217632293701,
0.22612978518009186,
-0.20198287069797516,
-0.2861076295375824,
-0.03424752503633499,
0.08591927587985992,
0.09662410616874695,
-0.34265971183776855,
0.4042194187641144,
-0.19966468214988708,
-0.5296714901924133,
-0.3469468057155609,
0.080622598528862,
-0.31443312764167786,
-0.33185169100761414,
-0.029737578704953194,
0.009686287492513657,
0.04964620620012283,
-0.2783127725124359,
-0.09863869845867157,
0.2152533084154129,
0.17606106400489807,
-0.27200764417648315,
-0.06402286887168884,
0.15900716185569763,
0.2513732314109802,
0.33631521463394165,
0.0892106220126152,
-0.9132408499717712,
0.24233151972293854,
0.9032140374183655,
0.06709235161542892,
0.3714461624622345,
-0.3186229169368744,
0.08040641993284225,
0.061388712376356125,
-0.7538976669311523,
0.08378326147794724,
-0.24632863700389862,
-0.16326110064983368,
0.11258788406848907,
-0.4282737672328949,
-0.11385326832532883,
0.03295225277543068,
-0.3267587125301361,
-0.1878393292427063,
-0.46185895800590515,
0.22595486044883728,
-0.07260555773973465,
0.12472721189260483,
-0.771509051322937,
-0.2850559949874878,
0.10401985794305801,
0.3287544846534729,
-0.06527169793844223,
-0.18285739421844482,
-0.32577240467071533,
0.49237626791000366,
0.5144788026809692,
0.09984754025936127,
0.15777568519115448,
-0.45651909708976746,
-0.7237062454223633,
-0.3093143701553345,
0.25935599207878113,
0.6654881834983826,
0.2395084947347641,
-0.028470994904637337,
-0.09710773825645447,
0.020437773317098618,
-0.6158506870269775,
0.20381926000118256,
0.03584781661629677,
-0.1297455132007599,
0.024819759652018547,
0.1673346757888794,
-0.45984914898872375,
0.3539385497570038,
0.07157523185014725,
0.0007680270355194807,
0.15804287791252136,
-0.4044143259525299,
0.3097800016403198,
0.09015277773141861,
0.01582130417227745,
-0.6545389294624329,
0.055568572133779526,
0.8907729983329773,
-0.17953121662139893,
0.08649536967277527,
-0.17953883111476898,
-0.6173044443130493,
-0.02518412657082081,
0.5865553617477417,
-0.04366185516119003,
0.2774007320404053,
0.0025393860414624214,
-0.39650586247444153,
-0.2227405309677124,
0.8514624238014221,
0.348592072725296,
-0.8350913524627686,
0.21361380815505981,
0.3804263174533844,
0.2645949125289917,
-0.6177135109901428,
0.10870639979839325,
0.07295709103345871,
-0.5400702357292175,
0.10756077617406845,
0.1805589497089386,
-0.3442419767379761,
0.0489250123500824,
0.36452239751815796,
0.6284340023994446,
0.20815213024616241,
-0.6189197301864624,
-0.25733482837677,
0.08386539667844772,
0.4373296797275543,
0.5009868741035461,
-0.7067797183990479,
-0.5194279551506042,
0.1829593926668167,
0.23202279210090637,
0.06231533735990524,
-0.11619406938552856,
0.5556979179382324,
0.8790413737297058,
-0.10244888067245483,
0.0869535505771637,
-0.30526003241539,
-0.16052541136741638,
0.009410593658685684,
0.026560265570878983,
0.2444576919078827,
-0.2315095067024231,
0.039902396500110626,
-0.2222922295331955,
-0.12916715443134308,
-0.3627319931983948,
-0.14540238678455353,
-0.050319306552410126,
0.44898322224617004,
-0.012053115293383598,
0.30239179730415344,
1.0601563453674316,
0.266101211309433,
-0.5413750410079956,
0.7597085237503052,
-0.5002431273460388,
-0.0427771657705307,
-0.5739410519599915,
0.23274867236614227,
-0.35635194182395935,
-0.2829821705818176,
-0.10252940654754639,
-0.10233563184738159,
0.21275806427001953,
-0.3700975477695465,
0.09411439299583435,
-0.3965330719947815,
0.3773624300956726,
-0.21995307505130768,
-0.2999727129936218,
-0.042067356407642365,
-0.69375079870224,
-0.1566314995288849,
0.26808422803878784,
0.00551610765978694,
-0.33464109897613525,
0.19480298459529877,
-0.22853805124759674,
-0.1904914528131485,
-0.6392863988876343,
0.8386327028274536,
0.4357891082763672,
-0.3825882375240326,
0.08264388144016266,
0.04460335522890091,
-0.05428599193692207,
0.42332082986831665,
-0.22193150222301483,
-0.1095668151974678,
0.522199809551239,
-0.10531364381313324,
-0.12487446516752243,
0.24608565866947174,
-0.07262689620256424,
0.24444490671157837,
0.10468025505542755,
-0.23740580677986145,
-0.023930620402097702,
-0.17584557831287384,
0.43758705258369446,
0.7745598554611206,
0.09340109676122665,
-0.3449694812297821,
-0.37675192952156067,
0.32201534509658813,
0.16482073068618774,
-0.06319456547498703,
-0.013209577649831772,
0.7609441876411438,
0.9696148633956909,
-0.13967512547969818,
-0.2584392726421356,
0.4274553060531616,
-0.1441531479358673,
0.3602147102355957,
0.20555639266967773,
-0.4496840238571167,
-0.012822895310819149,
0.42125752568244934,
0.6444020867347717,
0.3510082960128784,
-0.3173675239086151,
0.012088585644960403,
-0.28923144936561584,
0.4566037654876709,
0.26420047879219055,
0.26277467608451843,
0.3572092652320862,
0.034020595252513885,
0.43120864033699036,
-0.7069629430770874,
-0.1456422507762909,
-0.020823132246732712,
-0.09831678867340088,
0.043857213109731674,
0.7473385334014893,
-0.35224267840385437,
-0.4027400016784668,
-0.0208329688757658,
-0.0841095969080925,
0.20466791093349457,
-0.025985900312662125,
0.5626203417778015,
0.6921473741531372,
-0.10460811108350754,
0.2053956836462021,
-0.3581490218639374,
0.06235644221305847,
-0.10428827255964279,
0.24806320667266846,
-0.23308321833610535,
-0.053522903472185135,
0.13925063610076904,
0.1816757619380951,
0.23151487112045288,
0.050551678985357285,
0.3290109932422638,
0.3448043763637543,
0.6813325881958008,
-0.658674418926239,
-0.3454253673553467,
0.08876816183328629,
-0.11057589948177338,
0.07028081268072128,
-0.38778334856033325,
0.179543599486351,
-0.21178247034549713,
-0.21856757998466492,
-0.3655994236469269,
0.04184972122311592,
-1.0214544534683228,
-0.1413194239139557,
0.283572256565094,
0.20585039258003235,
-0.00005787876943941228,
0.29639890789985657,
0.47112786769866943,
-0.22516733407974243,
0.565523624420166,
-0.23140022158622742,
0.02426198311150074,
-0.36685144901275635,
-0.008289447985589504,
-0.7172691822052002,
0.4837174117565155,
-0.1518680304288864,
0.34948426485061646,
-0.9028764963150024,
0.1521390974521637,
0.9143484830856323,
0.37368375062942505,
-0.08034217357635498,
0.2569005787372589,
-0.010641629807651043,
0.3049842119216919,
-0.008836350403726101,
-0.6239312291145325,
-0.10156972706317902,
-0.8584994077682495,
-0.258804053068161,
-0.7313833832740784,
0.10093600302934647,
0.19102723896503448,
-0.07731741666793823,
0.3193562924861908,
0.25836825370788574,
0.47923681139945984,
-0.5491319298744202,
0.25326913595199585,
-0.13297882676124573,
0.18342210352420807,
-0.09301720559597015,
-0.008154893293976784,
-0.5486006736755371,
-0.12390993535518646,
0.15806593000888824,
0.41690340638160706,
0.10078148543834686,
0.07305547595024109,
0.6594505310058594,
-0.06361658871173859,
-0.0034720790572464466,
0.09838218986988068,
0.018864572048187256,
-0.05018434301018715,
-0.09001259505748749,
0.23795104026794434,
-0.7266570329666138,
0.2571259140968323,
0.2162272036075592,
-0.4823199510574341,
0.11630214750766754,
-0.04819262772798538,
0.26684412360191345,
-0.02001054584980011,
-0.1977481245994568,
0.0935031846165657,
0.013747169636189938,
0.29043278098106384
] |
Solid tumors are known to recruit new blood vessels to support their growth. Therefore, unique molecules expressed on tumor endothelial cells can function as targets for the antiangiogenic therapy of cancer. Current efforts are focusing on developing therapeutic agents capable of specifically targeting cancer cells and tumor-associated microenvironments including tumor blood vessels. These therapies hold the promise of high efficacy and low toxicity. One recognized strategy for improving the therapeutic effectiveness of conventional chemotherapeutics is to encapsulate anticancer drugs into targeting liposomes that bind to the cell surface receptors expressed on tumor-associated endothelial cells. These anti-angiogenic drug delivery systems could be used to target both tumor blood vessels as well as the tumor cells, themselves. This article reviews the mechanisms and advantages of various present and potential methods using peptide-conjugated liposomes to specifically destroy tumor blood vessels in anticancer therapy. | [
-0.0015169251710176468,
0.004122241400182247,
-0.012042047455906868,
0.013322792947292328,
0.03327053040266037,
-0.008042518980801105,
0.00965117197483778,
0.007162786088883877,
-0.010585841722786427,
-0.007313194684684277,
-0.006763873156160116,
0.012898420915007591,
-0.013372067362070084,
0.020299173891544342,
-0.007560042664408684,
0.0030404517892748117,
-0.021524228155612946,
-0.007435947190970182,
0.009880183264613152,
0.0047213369980454445,
-0.007603884674608707,
-0.023238059133291245,
0.01022353582084179,
-0.03284392133355141,
-0.007199693471193314,
0.0035068178549408913,
-0.012674630619585514,
-0.011194423772394657,
-0.005215035285800695,
-0.004924125503748655,
-0.0012580547481775284,
-0.0065759336575865746,
0.03924301266670227,
-0.027350902557373047,
-0.001981046050786972,
-0.03390413150191307,
-0.0006874619866721332,
0.022044092416763306,
0.006013941019773483,
-0.004001532681286335,
0.004478932823985815,
-0.008048482239246368,
-0.0036300034262239933,
0.0014458466321229935,
-0.007567344233393669,
-0.004562003538012505,
-0.003064404707401991,
0.01778438687324524,
0.004446931648999453,
0.009339923039078712,
0.0006948681548237801,
-0.004051355179399252,
-0.005353275220841169,
0.0031613819301128387,
-0.006387817673385143,
-0.007793893571943045,
0.01798698492348194,
-0.019693642854690552,
0.007542317733168602,
-0.00203234376385808,
0.002329410519450903,
0.012879526242613792,
0.004183526150882244,
-0.004993815906345844,
0.023100003600120544,
-0.06743298470973969,
0.005656201392412186,
-0.00546079920604825,
-0.0012114515993744135,
-0.020126309245824814,
0.019560836255550385,
0.01022395770996809,
0.004160727374255657,
-0.005650779698044062,
-0.013369843363761902,
0.00939963385462761,
-0.011267700232565403,
-0.022298861294984818,
0.020103946328163147,
0.007122135255485773,
-0.0037183118984103203,
0.007631081156432629,
-0.012707158923149109,
0.018132032826542854,
0.019040850922465324,
0.0029777800664305687,
-0.016517365351319313,
-0.010644364170730114,
0.020307734608650208,
-0.009744985029101372,
-0.010281077586114407,
-0.0026608379557728767,
-0.02996162697672844,
0.012738026678562164,
0.021611295640468597,
-0.0012086797505617142,
0.00008142180740833282,
0.0009313076734542847,
0.013854198157787323,
-0.008923460729420185,
-0.009107990190386772,
-0.014032905921339989,
0.013903849758207798,
0.019785894080996513,
-0.02375904470682144,
0.01114733051508665,
-0.00007514655590057373,
0.01946430280804634,
0.023681845515966415,
0.010221447795629501,
0.004202204290777445,
0.007575162686407566,
0.0024664723314344883,
0.0003286626888439059,
0.0063161700963974,
-0.028473123908042908,
-0.006845013238489628,
-0.014174403622746468,
0.01445910707116127,
0.023547451943159103,
0.0010763001628220081,
-0.005663702264428139,
-0.0012038338463753462,
-0.0008937856182456017,
0.005980057176202536,
-0.017663583159446716,
-0.003474991302937269,
-0.005562400445342064,
0.004401287063956261,
-0.0031154989264905453,
-0.010074727237224579,
0.009720178321003914,
0.025015542283654213,
-0.0062713343650102615,
-0.013878583908081055,
0.006714073941111565,
-0.021084532141685486,
-0.008119680918753147,
0.004663691855967045,
-0.02267325110733509,
0.026136595755815506,
0.006424952298402786,
-0.0012523781042546034,
0.00643537612631917,
-0.021832657977938652,
-0.006437528878450394,
0.007593505550175905,
0.001614257926121354,
-0.005108170211315155,
0.005147142335772514,
-0.013254315592348576,
0.009083290584385395,
-0.012058326974511147,
-0.014644784852862358,
0.009729604236781597,
-0.011801748536527157,
-0.00668636430054903,
0.0007158010266721249,
-0.004861439578235149,
-0.02030613087117672,
-0.013921932317316532,
-0.032300375401973724,
0.004523539915680885,
0.009298238903284073,
-0.0021177087910473347,
-0.005881999619305134,
0.0054923128336668015,
-0.0006279988447204232,
0.011179888620972633,
0.007059406489133835,
-0.010362230241298676,
-0.0035648918710649014,
-0.019678883254528046,
0.011456497013568878,
-0.015143648721277714,
0.015981240198016167,
0.013074822723865509,
0.007330599706619978,
-0.007082946598529816,
0.0669865757226944,
0.017865385860204697,
0.0017576355021446943,
0.01081493403762579,
-0.018407056108117104,
0.010129334405064583,
-0.004365873988717794,
0.02029126137495041,
-0.005274482071399689,
-0.01822047121822834,
-0.002569899195805192,
0.004499628208577633,
0.00652973772957921,
0.0011979350820183754,
-0.006281559355556965,
-0.013862029649317265,
0.003279180498793721,
0.008013731800019741,
0.006709654815495014,
-0.028469134122133255,
-0.011472124606370926,
-0.004851953592151403,
-0.008420232683420181,
-0.012806233949959278,
-0.030913032591342926,
-0.008566422387957573,
0.01770584098994732,
-0.01173705980181694,
-0.026875358074903488,
0.001319290604442358,
0.0016224910505115986,
0.02862267941236496,
-0.010611940175294876,
-0.01901102252304554,
0.0008603991009294987,
0.017806414514780045,
0.012188754975795746,
-0.024048637598752975,
0.016488926485180855,
-0.04394850134849548,
-0.011170925572514534,
-0.00029855920001864433,
0.022994279861450195,
0.00468842126429081,
0.014532534405589104,
0.010272097773849964,
0.0156662929803133,
0.005370252765715122,
0.009901249781250954,
0.017988480627536774,
0.009714698418974876,
0.0009086271747946739,
-0.0033361869864165783,
-0.012804413214325905,
0.01195079181343317,
-0.002177615649998188,
-0.004726807586848736,
0.012938925065100193,
-0.0010497737675905228,
0.023557662963867188,
-0.011888494715094566,
0.013309603556990623,
0.004004312679171562,
0.028809305280447006,
-0.01669672131538391,
0.008091820403933525,
0.007758449763059616,
0.0029542536940425634,
-0.010353382676839828,
0.0052162958309054375,
-0.0009005505125969648,
0.006392998155206442,
-0.003999289125204086,
0.009432334452867508,
0.006133103743195534,
0.0026272106915712357,
0.004553346894681454,
-0.00369180366396904,
-0.004598434083163738,
0.02424410730600357,
-0.01898459531366825,
-0.0053452118299901485,
0.00893144216388464,
0.02473561465740204,
-0.007049231790006161,
0.015030707232654095,
-0.004733261186629534,
-0.0021419108379632235,
-0.0028001307509839535,
0.0012973942793905735,
0.01702526956796646,
0.006282649002969265,
0.0010529879946261644,
0.0047808680683374405,
-0.08139421790838242,
-0.010169219225645065,
0.007526739034801722,
0.025005053728818893,
0.013552902266383171,
-0.005892062559723854,
0.022376658394932747,
0.012416853569447994,
-0.005374944768846035,
-0.01758366823196411,
-0.012789799831807613,
0.017779774963855743,
-0.0020860163494944572,
0.01482522301375866,
0.004008895251899958,
0.0022464077919721603,
0.01074322871863842,
-0.010023968294262886,
0.010532926768064499,
-0.039792004972696304,
0.026084601879119873,
0.004642882384359837,
-0.01975192129611969,
0.007618539035320282,
-0.024399179965257645,
0.052557479590177536,
0.003357497975230217,
0.019181014969944954,
-0.009927954524755478,
0.006888220552355051,
0.021738063544034958,
-0.00012118229642510414,
-0.011867733672261238,
-0.003417510073632002,
0.008594625629484653,
-0.014762280508875847,
-0.01531771570444107,
-0.02554137259721756,
-0.0186668299138546,
0.02090805023908615,
-0.008321018889546394,
0.008146485313773155,
0.00314438808709383,
0.012571313418447971,
0.021988337859511375,
0.017180193215608597,
0.00016539264470338821,
0.029737021774053574,
0.014281554147601128,
-0.02293344959616661,
0.015900611877441406,
0.01869896426796913,
0.014930072240531445,
0.017735807225108147,
-0.01238331664353609,
-0.014395575039088726,
-0.019496485590934753,
-0.010461078025400639,
-0.01384554523974657,
-0.008663656190037727,
0.010814007371664047,
-0.028374018147587776,
0.014126282185316086,
0.023900916799902916,
-0.000414692098274827,
-0.008373808115720749,
-0.0000027475180104374886,
0.020713940262794495,
-0.012344546616077423,
0.0046862890012562275,
0.021386973559856415,
0.01727522350847721,
-0.015148838981986046,
-0.007923049852252007,
-0.03188110142946243,
-0.006819017697125673,
-0.014636958949267864,
-0.0016895312583073974,
-0.010545274242758751,
-0.010928192175924778,
0.000625088345259428,
0.004377899691462517,
-0.028224527835845947,
-0.009867481887340546,
-0.0028688458260148764,
-0.030834414064884186,
0.010765100829303265,
0.039457015693187714,
-0.0036539845168590546,
-0.013850163668394089,
-0.026521358639001846,
-0.007517949678003788,
-0.019996503368020058,
0.0034741228446364403,
0.01988374814391136,
-0.034477658569812775,
0.0023302887566387653,
0.027468301355838776,
0.025326907634735107,
0.009448112919926643,
-0.030186928808689117,
-0.0027663561049848795,
-0.009602129459381104,
-0.013259484432637691,
-0.03192935883998871,
0.01093321479856968,
0.025341570377349854,
-0.0352875292301178,
0.00011359294876456261,
-0.0002936196397058666,
-0.032892219722270966,
-0.0007155789062380791,
-0.008305570110678673,
0.01863282546401024,
0.009138216264545918,
0.024718593806028366,
0.002885785885155201,
-0.018491331487894058,
0.0725211650133133,
-0.010570553131401539,
-0.00010517367627471685,
-0.007741759531199932,
0.013507705181837082,
-0.016587987542152405,
-0.019930757582187653,
0.004065633285790682,
-0.015564057976007462,
-0.018289342522621155,
0.012102426961064339,
0.0017991766799241304,
0.05581306293606758,
0.0010178706143051386,
-0.007167520001530647,
0.00003623473457992077,
-0.00890275277197361,
0.006514655891805887,
-0.017124967649579048,
-0.02882658690214157,
-0.0010262507712468505,
0.0038712541572749615,
-0.0022138485219329596,
0.010210822336375713,
0.005208303220570087,
-0.036192841827869415,
0.0067983996123075485,
-0.008539168164134026,
-0.0193265900015831,
0.005730627570301294,
0.0053710839711129665,
-0.017376529052853584,
-0.0021203961223363876,
-0.011778527870774269,
0.0074876765720546246,
0.0046541728079319,
0.008151630870997906,
-0.00400370080024004,
-0.00180580944288522,
-0.0006594657897949219,
0.012106293812394142,
-0.01113792322576046,
0.008120832033455372,
0.023194625973701477,
0.0038492195308208466,
-0.013624940998852253,
-0.01722308062016964,
-0.006442465353757143,
0.006010056007653475,
0.00015218020416796207,
-0.01711450144648552,
0.004458659328520298,
0.008351522497832775,
-0.010527996346354485,
-0.007032760418951511,
0.0060771144926548,
0.001752201933413744,
-0.000768434489145875,
-0.007281391881406307,
0.0028551737777888775,
-0.026027772575616837,
0.030521754175424576,
0.022163303568959236,
-0.0033053464721888304,
0.010510367341339588,
-0.001546297688037157,
-0.009027802385389805,
0.005245198495686054,
0.012161226011812687,
-0.03258761763572693,
-0.013294642791152,
0.011035099625587463,
-0.0025538261979818344,
-0.004070749506354332,
-0.021876579150557518,
0.015809599310159683,
0.009906462393701077,
0.00821119174361229,
0.027822116389870644,
0.006164287216961384,
-0.0012585865333676338,
0.005661377217620611,
0.03316473215818405,
-0.008410812355577946,
0.00025457353331148624,
-0.0017903158441185951,
-0.0021953796967864037,
-0.07523993402719498,
0.00449754111468792,
0.012348471209406853,
-0.00438994774594903,
-0.004273783881217241,
0.02916835993528366,
-0.009738285094499588,
0.003742293454706669,
0.027134260162711143,
-0.007585747167468071,
0.007872236892580986,
0.022915568202733994,
0.0018706601113080978,
0.007762756198644638,
0.01371675543487072,
0.007064120378345251,
-0.0019690338522195816,
-0.01650811731815338,
-0.011272255331277847,
-0.007864602841436863,
0.02076740190386772,
0.03545403853058815,
-0.009145479649305344,
0.011193095706403255,
0.00570629583671689,
-0.08146417140960693,
-0.008770106360316277,
-0.015678485855460167,
-0.036843493580818176,
0.006358556915074587,
-0.0022602840326726437,
-0.007356164511293173,
-0.003592421067878604,
-0.009623581543564796,
-0.014204831793904305,
-0.0009559975005686283,
0.0009016366675496101,
-0.0014089930336922407,
-0.0004677248653024435,
-0.011050079017877579,
-0.008120291866362095,
0.0006672218441963196,
0.00019550789147615433,
0.0006094102282077074,
-0.00101828807964921,
0.020417459309101105,
0.0027733868919312954,
-0.00745485769584775,
0.005712958984076977,
-0.011235222220420837,
0.003851299174129963,
0.0001705186441540718,
0.011601288802921772,
-0.005165893118828535,
0.012218087911605835,
-0.002821010537445545,
-0.0049818409606814384,
-0.010701166465878487,
-0.020513363182544708,
-0.022999625653028488,
-0.017376184463500977,
0.0066273147240281105,
0.008204171434044838,
-0.013183092698454857,
-0.012747746892273426,
-0.013917345553636551,
0.015176995657384396,
-0.033393483608961105,
-0.009219015017151833,
0.011677882634103298,
-0.01523502729833126,
0.00836116075515747,
-0.0005353577435016632,
0.007151896134018898,
0.0493323914706707,
0.003818232100456953,
-0.026397328823804855,
-0.010370677337050438,
-0.0008334408048540354,
-0.009051928296685219,
0.021600615233182907,
0.0020747031085193157,
-0.012442703358829021,
-0.01771191693842411,
0.009058935567736626,
-0.00018400338012725115,
0.007393303327262402,
-0.009496728889644146,
0.07193762809038162,
0.0034596268087625504,
0.009326678700745106,
-0.01726686768233776,
0.0006062074098736048,
0.00841117836534977,
-0.014145978726446629,
0.0044877296313643456,
-0.0249515138566494,
-0.0075272973626852036,
0.02552202343940735,
-0.010829197242856026,
-0.00022185826674103737,
0.007473134435713291,
-0.014600761234760284,
-0.004495938308537006,
-0.007399590685963631,
-0.003169600386172533,
0.026974283158779144,
-0.009281340055167675,
-0.01341572031378746,
-0.01839923858642578,
-0.05603162571787834,
0.001066057477146387,
0.012405280023813248,
-0.008519016206264496,
-0.03671906888484955,
-0.016053928062319756,
-0.019169621169567108,
-0.013197874650359154,
-0.004274999722838402,
0.02700076438486576,
-0.003143802983686328,
0.020403791218996048,
0.024252621456980705,
0.028444455936551094,
-0.024252038449048996,
-0.003042946569621563,
-0.004113375209271908,
-0.02447683736681938,
-0.03183969482779503,
0.005572853609919548,
-0.0008092642528936267,
-0.006918869446963072,
0.008242595940828323,
0.00029887864366173744,
0.0005627968348562717,
0.007496044971048832,
-0.005086453631520271,
0.017389923334121704,
-0.00832294300198555,
0.003055070759728551,
0.0044498927891254425,
-0.01909993216395378,
0.007698076777160168,
0.016059115529060364,
0.017167959362268448,
0.012224260717630386,
-0.006484734360128641,
-0.015240592882037163,
0.011306957341730595,
-0.008061468601226807,
0.005341910757124424,
-0.009269713424146175,
0.008327077142894268,
-0.005713373888283968,
0.01294027641415596,
-0.006748735439032316,
0.007333280052989721,
0.011672631837427616,
0.0036326481495052576,
0.005873754620552063,
0.007808033376932144,
-0.022533204406499863,
0.0016617346554994583,
-0.007956936955451965,
0.005551771726459265,
-0.008738257922232151,
-0.0022579366341233253,
0.011757388710975647,
-0.003185567446053028,
0.009635064750909805,
0.02511281706392765,
-0.0065223826095461845,
-0.04920760542154312,
-0.002909870818257332,
0.005299987271428108,
0.012684904970228672,
-0.0072606815956532955,
0.013903049752116203,
0.015066229738295078,
-0.010689830407500267,
-0.002997717587277293,
0.0022876609582453966,
0.0066460175439715385,
0.03432459011673927,
-0.010282255709171295,
-0.007075769826769829,
0.006063499487936497,
0.01824994385242462,
-0.003213803982362151,
0.0101801548153162,
-0.010383489541709423,
-0.022837728261947632,
-0.02003305032849312,
-0.005523619242012501,
0.00918226595968008,
0.009311584755778313,
0.008113976567983627,
-0.003253730945289135,
-0.01845075562596321,
-0.0018777450313791633,
0.0049673146568238735,
0.007353906985372305,
-0.010713509283959866,
0.0429590605199337,
-0.00832686759531498,
0.021582752466201782,
-0.007811505813151598,
-0.012744288891553879,
-0.010198256932199001,
0.013115251436829567,
0.003592028748244047,
0.008713403716683388,
-0.015000171959400177,
0.005651398561894894,
-0.004929624497890472,
0.015300844796001911,
-0.02873861975967884,
0.000688416650518775,
0.008989326655864716,
-0.023179616779088974,
-0.010120939463376999,
0.0050395457074046135,
-0.0014040693640708923,
0.02268321067094803,
-0.004251318052411079,
0.005156503990292549,
-0.012651322409510612,
0.007715757004916668,
0.015683485195040703,
-0.019078020006418228,
-0.002649090252816677,
-0.0004716990515589714,
0.006267615593969822,
-0.0034854609984904528,
0.016972754150629044,
-0.01015422586351633,
0.014845781028270721,
-0.008219609037041664,
0.010074194520711899,
0.009355300106108189,
-0.011504145339131355,
-0.005661311559379101,
0.012338067404925823,
0.014118260703980923,
0.0015744955744594336,
-0.006593526341021061,
-0.005055461078882217,
-0.016675064340233803,
-0.006985649932175875,
-0.023040737956762314,
-0.008262984454631805,
-0.01829937845468521,
0.009706111624836922,
0.013936631381511688,
0.00798212829977274,
0.00968865305185318,
0.017552731558680534,
0.01498239953070879,
0.02479209564626217,
0.010884675197303295,
-0.003965510055422783,
0.009567072615027428,
-0.05036000907421112,
-0.00650893384590745,
-0.023322809487581253,
-0.012124938890337944,
0.0013021605554968119,
0.0007416890002787113,
0.00983661413192749,
-0.007672310806810856,
0.011303581297397614,
-0.006369756069034338,
-0.011597118340432644,
-0.017867911607027054,
0.0029851230792701244,
-0.005081776529550552,
0.0021493923850357533,
0.024931330233812332,
0.008276233449578285,
-0.014146964997053146,
-0.014322983101010323,
-0.0027329856529831886,
-0.007169632241129875,
0.00285832560621202,
0.02066889777779579,
-0.011402513831853867,
-0.002508715260773897,
-0.003331161104142666,
-0.012779968790709972,
-0.02115485444664955
] | [
0.06335170567035675,
0.499756783246994,
0.2725682258605957,
0.046292744576931,
0.5318167209625244,
0.09348808228969574,
0.11390698701143265,
-0.19639793038368225,
-0.25037625432014465,
-0.391537070274353,
0.07531670480966568,
0.7000969648361206,
-0.3941592574119568,
0.554105281829834,
-0.14239957928657532,
0.7130545973777771,
0.6446065902709961,
0.47638994455337524,
0.45954281091690063,
0.14528881013393402,
-0.6872427463531494,
-0.14793527126312256,
0.9697321653366089,
-0.30724138021469116,
0.32550525665283203,
-0.2561055123806,
0.2692430019378662,
0.1819651871919632,
-0.04865124821662903,
0.12969732284545898,
-0.3409552574157715,
0.2696581482887268,
-0.315836101770401,
0.04585131257772446,
0.5245776772499084,
0.3081001341342926,
-0.2054879367351532,
0.31832700967788696,
-0.15592226386070251,
-0.475688099861145,
-0.2224377691745758,
0.029494846239686012,
-0.24989204108715057,
0.3347755968570709,
-0.4437906742095947,
-0.3982308804988861,
-1.5830581188201904,
0.4220990538597107,
-0.19008289277553558,
-0.16361050307750702,
0.5019094347953796,
0.18546459078788757,
-0.24366137385368347,
0.09140613675117493,
0.34618425369262695,
0.11886799335479736,
-0.5716297626495361,
0.12099742889404297,
0.18932223320007324,
0.04600394517183304,
-0.3636612296104431,
-0.0843767523765564,
-0.7909138202667236,
0.00005824095569550991,
0.22640180587768555,
0.586740255355835,
0.17659099400043488,
-0.513857901096344,
-0.829515278339386,
-0.2980663478374481,
-0.17947427928447723,
-0.9485601782798767,
0.1465483009815216,
0.37887120246887207,
-0.12520276010036469,
0.07931119948625565,
0.14448139071464539,
-0.30815228819847107,
0.3414454162120819,
0.09992694109678268,
0.16300451755523682,
0.020664788782596588,
0.4276798963546753,
0.27032557129859924,
0.21725670993328094,
-0.07948071509599686,
-0.3313960134983063,
0.9533002972602844,
-0.2396351546049118,
-0.24749131500720978,
-0.39311161637306213,
0.07162676751613617,
0.29200518131256104,
0.12354125082492828,
0.46836772561073303,
-0.07224434614181519,
-0.130445197224617,
0.2655841112136841,
0.23060643672943115,
0.43069037795066833,
-0.3055873215198517,
-0.05985735356807709,
0.4973129332065582,
-0.06582941114902496,
-0.4288269877433777,
-0.34399694204330444,
-0.047597043216228485,
-0.23429304361343384,
-1.0574978590011597,
0.22528985142707825,
-0.5550441741943359,
0.04220544546842575,
-0.2009941041469574,
-0.22466735541820526,
-0.3228454291820526,
0.6618253588676453,
-0.07389600574970245,
-0.181418314576149,
-0.23732559382915497,
0.15854676067829132,
0.34870728850364685,
1.3333667516708374,
-0.2844608426094055,
0.12695424258708954,
0.3040311932563782,
0.39996036887168884,
1.037437081336975,
0.33322572708129883,
0.008098404854536057,
0.4305537939071655,
-0.27411583065986633,
1.044768214225769,
-0.43044036626815796,
-0.07912041991949081,
0.5125885009765625,
-0.9505220055580139,
0.2803584635257721,
-0.3092980980873108,
0.6016239523887634,
-0.20979474484920502,
-0.16599982976913452,
-0.31154337525367737,
-0.18765683472156525,
-0.18613862991333008,
0.23693974316120148,
-0.6922187805175781,
0.1339881420135498,
-0.5133705735206604,
-0.5090930461883545,
-0.35348981618881226,
-0.04933146759867668,
0.027301941066980362,
-0.4509527087211609,
0.24024908244609833,
-0.10096282511949539,
0.8865455389022827,
0.1434507817029953,
-0.14791451394557953,
-0.19051571190357208,
0.20257017016410828,
-0.14502333104610443,
0.06965256482362747,
-0.2837613523006439,
-0.37562283873558044,
-0.033354032784700394,
-0.4120413661003113,
0.11682786792516708,
-0.1775476634502411,
0.3556143641471863,
0.13111013174057007,
-0.4024929404258728,
0.1274958997964859,
-0.016353601589798927,
0.0693197101354599,
0.45933231711387634,
-0.3372145891189575,
0.7181446552276611,
0.37450477480888367,
0.052875369787216187,
-0.5840508341789246,
-0.7228326201438904,
0.4489772319793701,
0.04852047190070152,
-0.2736039161682129,
-0.09313049167394638,
-0.07161057740449905,
0.7073092460632324,
0.15138374269008636,
0.5419583320617676,
0.07582329213619232,
0.16119630634784698,
0.14123490452766418,
0.3643520176410675,
-0.7162060141563416,
1.3248249292373657,
0.07248536497354507,
-0.2923562824726105,
0.922893226146698,
-0.5332059264183044,
-0.16246841847896576,
-0.08681147545576096,
0.4553098678588867,
0.45219501852989197,
-0.6035178303718567,
-0.6397109627723694,
-0.705310583114624,
0.17785392701625824,
-0.4489867687225342,
0.2611537277698517,
0.10452321171760559,
0.9908574819564819,
-0.5307199358940125,
-0.40151461958885193,
-0.7295444011688232,
0.5243206024169922,
-0.2741383910179138,
-0.16674305498600006,
0.7876984477043152,
-0.5439497232437134,
0.1335020810365677,
0.4755682945251465,
-0.9982619881629944,
0.6001489758491516,
0.6623225212097168,
0.2775607705116272,
1.0548049211502075,
0.04637354612350464,
-0.629923939704895,
0.4937155246734619,
0.06480535864830017,
0.2783292233943939,
-0.26607033610343933,
0.25871577858924866,
-0.545477569103241,
-0.2389122098684311,
-0.008376074023544788,
0.14031991362571716,
-0.24515250325202942,
-0.1224806010723114,
-0.12397047877311707,
0.03730291128158569,
0.07987353950738907,
-0.7947176098823547,
0.16160482168197632,
0.06392402946949005,
-0.4682670533657074,
-0.4200802445411682,
-0.22156314551830292,
-0.6831007599830627,
-0.025834660977125168,
-0.7053053379058838,
-0.068210668861866,
-0.05181436240673065,
-0.7430780529975891,
0.2794751226902008,
0.04907390475273132,
-0.3352891504764557,
-0.17676879465579987,
-0.16613984107971191,
-0.6311436295509338,
-0.5552968978881836,
0.15090495347976685,
-0.007858332246541977,
0.4436667561531067,
-0.5142423510551453,
-0.08356275409460068,
-0.06496326625347137,
-0.1546960324048996,
0.5829746723175049,
0.7097426056861877,
0.3673608899116516,
0.22170747816562653,
-0.448894739151001,
0.04672064632177353,
-0.044018033891916275,
-0.761945366859436,
-0.17037536203861237,
0.8928767442703247,
-0.49752315878868103,
-0.39976346492767334,
0.3912339508533478,
1.2574771642684937,
0.8494104146957397,
0.10547337681055069,
-1.2085626125335693,
0.07722141593694687,
0.04044591262936592,
-0.26385948061943054,
-0.5149742364883423,
0.10290943831205368,
-0.9856547117233276,
0.08752117305994034,
-0.7722115516662598,
-0.008219177834689617,
-0.03410220518708229,
0.274061381816864,
-0.3114786744117737,
0.045563966035842896,
0.6153557300567627,
-0.07450269162654877,
-0.31923094391822815,
0.294130802154541,
-0.5602619051933289,
-0.21583211421966553,
-0.07633209228515625,
-0.02008417807519436,
-0.40417689085006714,
0.35561656951904297,
-5.473216533660889,
-0.1946878433227539,
0.13640591502189636,
-0.2574861943721771,
0.35940200090408325,
-0.2546618580818176,
0.299938827753067,
-0.13850745558738708,
0.500041663646698,
0.06369352340698242,
0.23500202596187592,
1.1436412334442139,
-0.05852625146508217,
-0.035741809755563736,
0.3302936851978302,
-0.2496734857559204,
0.3925161063671112,
-0.017406420782208443,
0.6724779009819031,
0.1077670156955719,
0.7454316020011902,
-0.2194046527147293,
0.25338268280029297,
0.8695218563079834,
-0.03986884653568268,
0.6907265186309814,
-0.5538173317909241,
0.29786983132362366,
-0.2254650890827179,
-0.674240231513977,
0.07474642246961594,
-0.35553887486457825,
-0.07529711723327637,
-0.07893159985542297,
0.587587833404541,
0.5130717158317566,
-0.16615839302539825,
-0.47193294763565063,
0.16683410108089447,
-0.15128596127033234,
0.7243040204048157,
0.26948660612106323,
-0.5603001713752747,
0.17486044764518738,
0.40036389231681824,
-0.45512038469314575,
-0.056316740810871124,
0.38228726387023926,
-0.5244051218032837,
1.044689655303955,
0.3594805598258972,
-0.39321959018707275,
0.24117708206176758,
0.7104038000106812,
0.3340294063091278,
0.31839942932128906,
-0.32700666785240173,
0.22845350205898285,
-0.5145711302757263,
0.2715705931186676,
-0.3397999703884125,
0.18858195841312408,
-0.5866777300834656,
-0.4309732913970947,
-0.18025845289230347,
-0.11652076244354248,
-0.6445682644844055,
-0.6738223433494568,
0.3812074363231659,
-0.18464091420173645,
-0.5773671865463257,
0.27059710025787354,
0.24778544902801514,
-0.38610371947288513,
0.6288432478904724,
0.02872292697429657,
0.17031815648078918,
-0.08460777997970581,
-0.20042674243450165,
0.23310799896717072,
-0.5477397441864014,
0.09038536250591278,
0.3465813100337982,
-0.4040968120098114,
0.12507398426532745,
-0.20997366309165955,
-0.39545774459838867,
0.017870772629976273,
-0.025478079915046692,
0.023747416213154793,
0.8479043841362,
-0.5688143372535706,
0.33711934089660645,
0.6328676342964172,
0.31181225180625916,
0.2222970426082611,
0.46391648054122925,
-0.05087260901927948,
0.7368515133857727,
-0.12699082493782043,
0.700107753276825,
0.4912278354167938,
-0.47873154282569885,
-1.0913203954696655,
-0.24351713061332703,
-0.2078392058610916,
-0.6803795099258423,
-0.2497497797012329,
0.2634742856025696,
-0.9316406846046448,
0.2845247983932495,
0.2511039972305298,
-0.006723239552229643,
-0.2739366590976715,
0.7895572781562805,
-0.37795302271842957,
-0.16449297964572906,
0.20400215685367584,
0.47155654430389404,
0.10129468142986298,
0.2651103734970093,
0.2666211426258087,
0.10853320360183716,
-0.032243285328149796,
0.4797316789627075,
-0.3676334023475647,
0.2607053518295288,
0.6742721796035767,
-0.8290681838989258,
-0.028644807636737823,
0.8775191903114319,
0.17921186983585358,
-0.270468145608902,
-0.08774932473897934,
0.21426016092300415,
-0.0712738111615181,
-0.6212773323059082,
0.00035607084282673895,
0.2994837462902069,
0.06436751782894135,
0.5583827495574951,
-0.21167457103729248,
-0.15956991910934448,
0.34339672327041626,
0.24859213829040527,
-0.2999861538410187,
-0.33694958686828613,
0.10257487744092941,
0.12901638448238373,
-0.05873676761984825,
-0.1943313479423523,
0.4325640797615051,
0.23090814054012299,
-0.5579046607017517,
0.07227224856615067,
0.07409479469060898,
0.44111883640289307,
-0.07275886088609695,
0.2424323856830597,
-0.374164879322052,
0.2583428621292114,
0.6266749501228333,
-0.7346910238265991,
0.14102718234062195,
-0.32810530066490173,
-0.39369457960128784,
-0.37743061780929565,
-0.10422679781913757,
0.31490132212638855,
0.6148343682289124,
-0.21715126931667328,
-0.35906216502189636,
-0.5392100214958191,
-0.24791882932186127,
0.13341064751148224,
-0.3381945490837097,
-0.10825750231742859,
0.3395393192768097,
-0.18326449394226074,
-0.4803071916103363,
0.2844359576702118,
-1.110724925994873,
-0.2033759504556656,
-0.07612195611000061,
0.5663055181503296,
0.33209145069122314,
-0.29936712980270386,
-0.37733036279678345,
-0.5174917578697205,
-0.55732262134552,
-0.19694381952285767,
-0.0587572418153286,
0.4448848366737366,
0.07749815285205841,
-0.011166938580572605,
-0.394104927778244,
-0.10053672641515732,
0.5429744720458984,
0.007391118444502354,
-0.5217434763908386,
0.3354095220565796,
0.32213032245635986,
-1.0474923849105835,
0.3282104432582855,
0.6165798306465149,
-0.5519205927848816,
0.1603451669216156,
0.3210678696632385,
0.4655350148677826,
-0.05841277167201042,
-0.15269015729427338,
-0.20228253304958344,
0.16642718017101288,
0.3653951585292816,
-0.33217763900756836,
0.1578589826822281,
0.30801334977149963,
0.05314674600958824,
0.037099529057741165,
0.21131297945976257,
0.27425333857536316,
-0.6874855756759644,
-0.25125616788864136,
-0.02075166255235672,
-0.6645106673240662,
0.3303588628768921,
0.6578619480133057,
-0.9492188096046448,
0.1284850835800171,
-0.1836545616388321,
0.05602990835905075,
-0.0654117688536644,
-0.4038486182689667,
-0.26290038228034973,
0.3495340645313263,
-0.14777901768684387,
-0.04555247351527214,
0.21219390630722046,
-0.1817183941602707,
0.24913515150547028,
-0.1805412769317627,
0.8282865881919861,
-0.4778173565864563,
-0.012428042478859425,
-0.016457516700029373,
0.3591305613517761,
0.843325138092041,
-0.7202844023704529,
-1.0614007711410522,
0.22879646718502045,
0.8868144750595093,
-0.5301446914672852,
0.016203127801418304,
-0.08600074797868729,
0.6789478659629822,
0.1539076566696167,
-0.4527439475059509,
-0.28189608454704285,
-0.4245036840438843,
0.4271647036075592,
-0.590971827507019,
-0.9648177027702332,
-0.24062316119670868,
-0.4506777226924896,
0.6231882572174072,
-0.4260714650154114,
-0.34918099641799927,
-0.556993305683136,
0.23378655314445496,
-0.7962172031402588,
-0.474865198135376,
0.19136202335357666,
0.5828417539596558,
0.05181710049510002,
-0.15538758039474487,
0.492501437664032,
-0.27890893816947937,
-0.17354132235050201,
-0.310419499874115,
0.38579127192497253,
-0.29874497652053833,
-0.04854963719844818,
0.33954334259033203,
-0.6272097229957581,
0.21671025454998016,
-0.5277438759803772,
0.20406022667884827,
-0.09884003549814224,
-0.15377596020698547,
-0.11322025954723358,
-0.08162026852369308,
0.14377820491790771,
-0.6388229131698608,
-0.33603689074516296,
-0.1580009162425995,
0.11448738723993301,
0.25300541520118713,
0.395158976316452,
0.016213873401284218,
-0.2134096622467041,
-0.12505653500556946,
0.5324144959449768,
0.5016893148422241,
-0.5595965385437012,
0.27285468578338623,
0.5046284198760986,
0.13761349022388458,
-0.37562185525894165,
0.05836300179362297,
-0.3903433680534363,
-0.33273038268089294,
0.03303498402237892,
0.22183583676815033,
0.42016342282295227,
-0.4753626585006714,
0.2927902638912201,
0.13898736238479614,
-0.51160728931427,
0.597117006778717,
0.15583638846874237,
0.1485997438430786,
0.23337146639823914,
0.16987824440002441,
-0.28702589869499207,
-0.5465066432952881,
0.5435442924499512,
-0.035645171999931335,
0.29891237616539,
0.13985136151313782,
-0.2081747055053711,
0.6867156028747559,
0.4841292202472687,
-0.2447446584701538,
0.1703610122203827,
0.36491894721984863,
0.03217368945479393,
0.46332237124443054,
-0.6631743907928467,
-0.9028692245483398,
0.21326547861099243,
0.5754415988922119,
0.13824522495269775,
-0.5074364542961121,
-0.018330736085772514,
-0.03633137047290802,
0.6824739575386047,
0.4157857596874237,
0.1350615918636322,
-0.6194188594818115,
0.4238850176334381,
-0.049993835389614105,
-0.08676188439130783,
-0.7725948095321655,
0.4917314648628235,
-0.21107089519500732,
-0.5316979289054871,
0.6350522041320801,
-0.48706045746803284,
-0.3222719728946686,
0.13086119294166565,
-0.251693457365036,
0.1710633933544159,
-0.08997785300016403,
0.5462988615036011,
-0.4419921934604645,
0.335435688495636,
0.8183907270431519,
-0.1472940444946289,
0.09149296581745148,
-0.35051530599594116,
-0.006092087831348181,
0.45859575271606445,
-0.1891046017408371,
0.729611873626709,
-0.19187533855438232,
-0.6747207045555115,
0.22604279220104218,
-0.17776288092136383,
0.18696101009845734,
0.28751713037490845,
0.03311500325798988,
0.2550402283668518,
-0.04046125337481499,
-0.42622503638267517,
0.085806705057621,
0.08915523439645767,
-0.199460968375206,
0.06836151331663132,
0.44586220383644104,
0.17294131219387054,
0.4622783362865448,
0.02290615253150463,
0.5322812795639038,
0.5013530850410461,
0.0203376654535532,
0.12823840975761414,
-0.20923198759555817,
0.7166739106178284,
-0.24017563462257385,
0.08555210381746292,
-0.07479269057512283,
0.6651387810707092,
-0.008148741908371449,
1.1949514150619507,
-0.9365928769111633,
0.17775273323059082,
-0.6599557995796204,
-0.5726807117462158,
-1.135656476020813,
0.0704130306839943,
0.7794502973556519,
0.5888850092887878,
-0.14005576074123383,
-0.32330629229545593,
-0.3104344606399536,
-0.011091483756899834,
0.3200255036354065,
-0.14692266285419464,
0.025660976767539978,
-0.37198227643966675,
0.009340167045593262,
-0.609367847442627,
0.5246642827987671,
0.0625547245144844,
-0.007938266731798649,
-0.700481116771698,
0.559542179107666,
0.3221178352832794,
-0.36519598960876465,
0.05447631701827049,
-0.218145951628685,
0.036562174558639526,
-0.5996059775352478,
0.7032797336578369,
-0.43027427792549133,
-0.3895920515060425,
0.018594317138195038,
0.26222535967826843,
0.058472178876399994,
-0.475159615278244,
-0.20311039686203003,
-0.07604807615280151,
0.2716628313064575,
0.033148571848869324,
0.34428179264068604,
0.15430417656898499,
-0.12742215394973755,
-0.600153923034668,
-0.7430932521820068,
0.6024875640869141,
-0.5253671407699585,
-0.6784743666648865,
0.25942233204841614,
0.10249175876379013,
-0.13969355821609497,
0.495683878660202,
-0.2152545154094696,
-0.4375747740268707,
-0.30828407406806946,
0.12284988164901733
] |
The earliest immune responses activated in acute human immunodeficiency virus type 1 infection (AHI) exert a critical influence on subsequent virus spread or containment. During this time frame, components of the innate immune system such as macrophages and DCs, NK cells, β-defensins, complement and other anti-microbial factors, which have all been implicated in modulating HIV infection, may play particularly important roles. A proteomics-based screen was performed on a cohort from whom samples were available at time points prior to the earliest positive HIV detection. The ability of selected factors found to be elevated in the plasma during AHI to inhibit HIV-1 replication was analyzed using in vitro PBMC and DC infection models. Analysis of unique plasma donor panels spanning the eclipse and viral expansion phases revealed very early alterations in plasma proteins in AHI. Induction of acute phase protein serum amyloid A (A-SAA) occurred as early as 5–7 days prior to the first detection of plasma viral RNA, considerably prior to any elevation in systemic cytokine levels. Furthermore, a proteolytic fragment of alpha–1-antitrypsin (AAT), termed virus inhibitory peptide (VIRIP), was observed in plasma coincident with viremia. Both A-SAA and VIRIP have anti-viral activity in vitro and quantitation of their plasma levels indicated that circulating concentrations are likely to be within the range of their inhibitory activity. Our results provide evidence for a first wave of host anti-viral defense occurring in the eclipse phase of AHI prior to systemic activation of other immune responses. Insights gained into the mechanism of action of acute-phase reactants and other innate molecules against HIV and how they are induced could be exploited for the future development of more efficient prophylactic vaccine strategies. | [
-0.017470011487603188,
0.010264798998832703,
-0.010077330283820629,
0.004829964600503445,
0.031219344586133957,
0.014950791373848915,
0.009115331806242466,
-0.0035280194133520126,
-0.013017096556723118,
-0.003989130258560181,
0.006668156944215298,
0.012296264991164207,
-0.01035061851143837,
0.014030683785676956,
-0.01514474581927061,
-0.008704999461770058,
0.006267068907618523,
0.026192087680101395,
0.008236464112997055,
0.004747261293232441,
-0.02578781172633171,
0.008461818099021912,
0.010878115892410278,
-0.03124047815799713,
0.01542646810412407,
0.017809007316827774,
0.006628085393458605,
-0.006198876071721315,
-0.016417568549513817,
0.008601628243923187,
-0.02677210420370102,
0.011634022928774357,
-0.008448807522654533,
-0.017163723707199097,
0.0066993506625294685,
-0.015834372490644455,
-0.005077933426946402,
0.020652826875448227,
0.010294193401932716,
-0.0017704297788441181,
0.03302153944969177,
-0.011315529234707355,
0.0010199202224612236,
-0.018935244530439377,
-0.00855841301381588,
-0.034213993698358536,
-0.0006291470490396023,
-0.016825532540678978,
-0.009189702570438385,
0.009336481802165508,
-0.009743006899952888,
-0.020343482494354248,
-0.006468735635280609,
-0.01255585066974163,
-0.006943546235561371,
0.02188754454255104,
0.018574059009552002,
-0.008446915075182915,
-0.018104035407304764,
0.028970882296562195,
0.00019725097808986902,
-0.012103992514312267,
0.025815702974796295,
-0.012674156576395035,
-0.015503013506531715,
-0.06686710566282272,
-0.00874311476945877,
0.02408302016556263,
-0.00009156856685876846,
-0.0011819805949926376,
0.004671817645430565,
0.007108232006430626,
-0.020529599860310555,
-0.0009391186758875847,
-0.03593062981963158,
-0.01987599954009056,
-0.013327588327229023,
0.04443948715925217,
-0.014069528318941593,
0.01630895957350731,
0.022565171122550964,
0.01683957688510418,
0.02592211216688156,
0.016576888039708138,
0.00030112324748188257,
0.00961381010711193,
-0.03364954888820648,
0.010088952258229256,
-0.005492848809808493,
0.002551511861383915,
0.0036790575832128525,
-0.017122291028499603,
-0.04044708237051964,
0.008890628814697266,
0.02311895228922367,
-0.026428990066051483,
-0.025016948580741882,
-0.009635268710553646,
0.019773175939917564,
-0.012297217734158039,
-0.02439817041158676,
-0.006380201783031225,
0.01365736685693264,
0.015381956472992897,
0.02333952859044075,
0.009882660582661629,
-0.003932810388505459,
0.004721158184111118,
0.017093895003199577,
0.007110065780580044,
-0.012963018380105495,
0.011976129375398159,
0.015386401675641537,
0.004496120382100344,
0.007236710749566555,
-0.01680673658847809,
-0.006816450506448746,
0.004320185165852308,
0.011785398237407207,
0.0017102742567658424,
0.027601519599556923,
-0.017258618026971817,
-0.004486460704356432,
0.010571926832199097,
-0.00044428615365177393,
-0.02603164315223694,
-0.032742977142333984,
0.0038207564502954483,
-0.009494280442595482,
-0.0012653464218601584,
-0.008104514330625534,
0.002603645669296384,
0.026768939569592476,
-0.010386859066784382,
-0.02454623207449913,
0.005742370150983334,
-0.0028175171464681625,
-0.001517687225714326,
-0.008044017478823662,
-0.020748693495988846,
-0.016907203942537308,
0.008347246795892715,
-0.0050001442432403564,
0.014735221862792969,
0.011657798662781715,
0.005619171541184187,
-0.039621785283088684,
0.004325099289417267,
0.01884789951145649,
0.00039902119897305965,
0.0012609672266989946,
-0.010179863311350346,
0.011667349375784397,
-0.022624243050813675,
-0.010364934802055359,
0.030409807339310646,
-0.01611815020442009,
-0.017841938883066177,
-0.017572389915585518,
0.012492017820477486,
-0.020494289696216583,
-0.01683998852968216,
0.004088058136403561,
0.010434663854539394,
0.02213841862976551,
-0.007611516863107681,
0.008655278012156487,
-0.015567544847726822,
0.015911296010017395,
0.013412516564130783,
0.0004156026989221573,
0.01484375074505806,
-0.012327827513217926,
0.014993886463344097,
-0.006300224922597408,
-0.0016409613890573382,
-0.008449627086520195,
0.010069729760289192,
-0.005599435418844223,
0.06643913686275482,
0.030923401936888695,
-0.015866883099079132,
0.000992757035419345,
0.01609700918197632,
0.01132396049797535,
-0.01251970324665308,
0.02000836841762066,
-0.01653890870511532,
-0.007592206820845604,
0.002860844135284424,
-0.022339796647429466,
-0.027354709804058075,
-0.007878700271248817,
-0.009978432208299637,
-0.037946321070194244,
0.0029801581986248493,
0.01984923705458641,
0.007008128799498081,
-0.014217138290405273,
0.0035413866862654686,
0.006659552920609713,
0.0051161847077310085,
0.03666126728057861,
0.02062314935028553,
-0.0539078488945961,
0.007293662987649441,
-0.0017693005502223969,
-0.004692013841122389,
-0.013953877612948418,
-0.012301064096391201,
0.013250863179564476,
-0.006428570486605167,
-0.011300676502287388,
-0.011678068898618221,
-0.012549849227070808,
-0.015589199028909206,
0.006059031002223492,
0.01970943808555603,
-0.012252253480255604,
-0.014933439902961254,
0.006123405881226063,
0.04279037564992905,
-0.016681665554642677,
0.03498411923646927,
0.009674906730651855,
-0.009884137660264969,
-0.008833274245262146,
0.007513262331485748,
-0.015167033299803734,
0.0019267166499048471,
-0.029751747846603394,
-0.004942673724144697,
-0.012245811522006989,
0.0012530116364359856,
0.0063003008253872395,
-0.0018359390087425709,
0.011921094730496407,
-0.008584127761423588,
0.023916034027934074,
-0.007945606485009193,
-0.025320524349808693,
-0.018343213945627213,
0.026792408898472786,
-0.017643563449382782,
0.015975117683410645,
0.021371424198150635,
-0.010309675708413124,
0.010928253643214703,
-0.012145927175879478,
-0.016932079568505287,
0.00848889909684658,
-0.019470561295747757,
-0.009764069691300392,
-0.03340158239006996,
0.0025942320935428143,
-0.016034692525863647,
0.029083073139190674,
-0.013347048312425613,
0.023624632507562637,
-0.02626011148095131,
-0.0040980312041938305,
0.003973968792706728,
-0.01413379330188036,
0.005874627269804478,
0.007815112359821796,
-0.013542832806706429,
-0.025903310626745224,
0.020382428541779518,
-0.0011272523552179337,
-0.01011594943702221,
0.008674010634422302,
-0.0026155617088079453,
0.015363024547696114,
-0.0811493992805481,
-0.013466216623783112,
-0.009084273129701614,
-0.01550332922488451,
0.00451368885114789,
-0.016244715079665184,
0.010267132893204689,
0.008820710703730583,
-0.002841077744960785,
-0.002601986052468419,
-0.006651891861110926,
0.023720307275652885,
-0.008631391450762749,
-0.013015049509704113,
-0.013276604935526848,
0.008441509678959846,
0.009661609306931496,
-0.02094634249806404,
-0.026709631085395813,
-0.01354246586561203,
-0.011234577745199203,
-0.0112482700496912,
0.034851640462875366,
-0.0012797183590009809,
0.005823763553053141,
0.012304755859076977,
0.024100948125123978,
-0.0014626509509980679,
-0.02052907645702362,
-0.0024084525648504496,
0.0230221189558506,
-0.00931788794696331,
0.022947879508137703,
0.017060093581676483,
0.040514327585697174,
0.001760766375809908,
-0.0054679145105183125,
-0.04313389211893082,
-0.022420139983296394,
-0.008450347930192947,
-0.016391843557357788,
0.01276353932917118,
0.023533053696155548,
0.021283194422721863,
0.01754741743206978,
-0.014430996030569077,
0.016909698024392128,
0.03587795048952103,
0.01345454528927803,
0.011111517436802387,
-0.006690277252346277,
-0.009296159259974957,
0.010219461284577847,
0.020176716148853302,
-0.006249972619116306,
-0.03257616609334946,
-0.007113704923540354,
0.026003453880548477,
-0.01038571447134018,
-0.003173558274284005,
-0.004066945984959602,
-0.009955596178770065,
0.008932428434491158,
0.0009997966699302197,
-0.03106125444173813,
0.02689136192202568,
0.009452196769416332,
0.03579738736152649,
-0.011635941453278065,
0.022040879353880882,
-0.03952731937170029,
0.008244477212429047,
-0.0009091338142752647,
-0.012723573483526707,
0.010812685824930668,
-0.00341937062330544,
-0.013833193108439445,
-0.013585496693849564,
-0.0009575866861268878,
-0.010644622147083282,
-0.025339847430586815,
0.001255309209227562,
-0.0011169197969138622,
-0.012088410556316376,
-0.011177051812410355,
-0.008369175717234612,
0.003866960294544697,
0.03754456341266632,
0.01718354970216751,
-0.015454839915037155,
0.00831233523786068,
0.051391683518886566,
-0.014193536713719368,
0.014273073524236679,
-0.00039567146450281143,
-0.0018807393498718739,
-0.024468185380101204,
0.0013762470334768295,
0.0006343722343444824,
0.008540669456124306,
-0.032474249601364136,
-0.015831701457500458,
-0.05165044963359833,
-0.008991512469947338,
0.021850116550922394,
0.013176283799111843,
0.0048753609880805016,
0.00883865263313055,
-0.02108774334192276,
0.00016859069000929594,
0.03818155825138092,
0.009091075509786606,
-0.005058995448052883,
-0.007064844947308302,
0.009257744997739792,
0.026289666071534157,
0.0007982680108398199,
-0.01163727231323719,
0.07203736901283264,
-0.01925053820014,
0.0038499694783240557,
-0.01181933842599392,
0.01181826088577509,
-0.019607994705438614,
-0.012126702815294266,
-0.00839268695563078,
0.0045526353642344475,
-0.0003151900600641966,
0.012087151408195496,
-0.028413940221071243,
-0.024397391825914383,
0.008301740512251854,
-0.015963250771164894,
-0.004821199923753738,
-0.004174486268311739,
-0.054494477808475494,
0.036475833505392075,
-0.004302440211176872,
-0.0038900631479918957,
-0.007567377295345068,
0.0023408103734254837,
-0.0020907907746732235,
0.02308070659637451,
-0.036754295229911804,
0.008148272521793842,
-0.009881357662379742,
-0.002687916625291109,
0.014242448844015598,
-0.018125483766198158,
-0.0030189407989382744,
-0.0060945493169128895,
0.0019478354370221496,
0.015349406749010086,
0.00612817844375968,
0.005876732990145683,
-0.006107020191848278,
-0.0012731414753943682,
-0.006321118213236332,
0.0008345143869519234,
-0.012356339022517204,
-0.014421900734305382,
0.010660030879080296,
-0.004518098197877407,
0.013607127591967583,
0.019669245928525925,
-0.007796854246407747,
-0.01321061048656702,
0.004155286587774754,
-0.009082427248358727,
-0.0011426126584410667,
0.009611532092094421,
0.011705951765179634,
-0.012288667261600494,
0.022918596863746643,
0.025745317339897156,
-0.0003128303214907646,
-0.0047663915902376175,
-0.015535722486674786,
-0.011062503792345524,
-0.01094927079975605,
0.02164119854569435,
-0.016645072028040886,
-0.007272003684192896,
0.001765351160429418,
0.0007315775146707892,
0.01227494701743126,
0.009367184713482857,
-0.023514412343502045,
0.03176173195242882,
-0.004546239972114563,
-0.024995232000947,
0.0081745944917202,
-0.03330112248659134,
-0.004986865445971489,
0.02638755366206169,
-0.006122002378106117,
0.030204160138964653,
0.020476579666137695,
-0.0024042262230068445,
-0.007243936415761709,
0.016387253999710083,
-0.005701943300664425,
-0.0018157397862523794,
-0.002706532832235098,
-0.02431657165288925,
-0.07453690469264984,
0.0056384545750916,
0.0022599464282393456,
-0.006938692647963762,
0.011004654690623283,
0.010504430159926414,
-0.020183458924293518,
0.0034265886060893536,
-0.030496172606945038,
0.00008844205876812339,
-0.002733037807047367,
-0.022584903985261917,
0.00574134849011898,
-0.0017473525367677212,
0.016547828912734985,
0.014367427676916122,
-0.004279239568859339,
-0.0029644761234521866,
-0.010018231347203255,
-0.014619069173932076,
0.024115653708577156,
-0.009915946051478386,
-0.03568354249000549,
0.007819358259439468,
0.0076757618226110935,
-0.08084146678447723,
0.007057234179228544,
0.012014990672469139,
-0.03486441820859909,
-0.003831450827419758,
-0.03127869591116905,
0.01223374716937542,
-0.015786930918693542,
-0.00572191271930933,
-0.016467221081256866,
-0.004095037002116442,
-0.0009558405727148056,
-0.0048668961971998215,
-0.0007646112353540957,
0.023185744881629944,
-0.008580529130995274,
0.006912510842084885,
0.0011899746023118496,
0.02052989974617958,
-0.005181767046451569,
0.0042083049193024635,
0.02700085937976837,
-0.010113280266523361,
0.01460357941687107,
-0.007804286666214466,
-0.03912600129842758,
-0.024816228076815605,
0.00889220368117094,
0.00003641471266746521,
0.0014111995697021484,
-0.0037475950084626675,
0.005857143551111221,
-0.01865249127149582,
-0.00827496126294136,
-0.012906556017696857,
-0.02101903036236763,
0.0017391778528690338,
0.00922261830419302,
0.021138738840818405,
0.008766680024564266,
-0.00956988800317049,
-0.0024890690110623837,
-0.02315196953713894,
0.013635033741593361,
0.0019623441621661186,
0.006874836981296539,
0.009080762043595314,
-0.007279594428837299,
0.013568617403507233,
0.008178028278052807,
0.003144938498735428,
-0.0011377953924238682,
0.014620119705796242,
0.007028418593108654,
0.018289420753717422,
0.021505990996956825,
-0.0019510395359247923,
0.017457695677876472,
-0.0015047667548060417,
0.013388442806899548,
-0.004658602178096771,
0.0026817796751856804,
0.02127857506275177,
0.07136908173561096,
-0.02150902710855007,
0.016933273524045944,
-0.0030238376930356026,
0.0010544820688664913,
0.001033431151881814,
-0.010345255956053734,
0.004562747199088335,
0.011473653838038445,
-0.01402157824486494,
-0.022506287321448326,
-0.015950439497828484,
0.012378943152725697,
0.013312535360455513,
0.0009678932838141918,
0.010331343859434128,
-0.018471544608473778,
-0.023823261260986328,
0.0020309900864958763,
0.048603497445583344,
0.03232590854167938,
0.008108236826956272,
-0.03263912722468376,
-0.022814849391579628,
0.03345819190144539,
-0.007928015664219856,
-0.019697094336152077,
0.004471858497709036,
-0.025571580976247787,
0.01597060076892376,
-0.015777871012687683,
-0.0067635891027748585,
-0.003646587487310171,
-0.014011972583830357,
0.026260890066623688,
0.007573241833597422,
-0.00006580771878361702,
0.013374203816056252,
-0.0007118262001313269,
0.03720996901392937,
0.004318493418395519,
-0.019059443846344948,
-0.0034673905465751886,
-0.015367075800895691,
0.030342649668455124,
-0.016333267092704773,
0.011076251044869423,
0.02422029711306095,
-0.008498714305460453,
0.020528731867671013,
0.006812067236751318,
0.003448028350248933,
0.02394615299999714,
0.011013137176632881,
-0.02914443612098694,
0.025133663788437843,
-0.02597874402999878,
0.016960786655545235,
-0.03035993129014969,
0.00299354107119143,
0.005236747208982706,
-0.026859015226364136,
0.01191085483878851,
-0.017816608771681786,
-0.007378401700407267,
-0.011957334354519844,
0.03644618019461632,
-0.007334889378398657,
-0.015581508167088032,
0.015623344108462334,
-0.01597161777317524,
0.016204833984375,
0.007860141806304455,
-0.007557796314358711,
0.023615781217813492,
0.007333782501518726,
0.03871496021747589,
0.0002974485978484154,
0.01731565222144127,
0.010651533491909504,
-0.010029613971710205,
-0.013539253734052181,
0.017799343913793564,
-0.004597647115588188,
0.007278552278876305,
0.007822727784514427,
0.0037829745560884476,
-0.029645610600709915,
-0.0008193916874006391,
0.0077583021484315395,
-0.0009492523968219757,
-0.004099720157682896,
0.0015387448947876692,
0.022779498249292374,
0.01052557397633791,
0.033767953515052795,
-0.011114918626844883,
0.005141361616551876,
0.021321972832083702,
-0.005423045251518488,
-0.03564333915710449,
-0.0022576795890927315,
-0.006489443592727184,
0.04177442938089371,
-0.021163292229175568,
0.003797742538154125,
0.024918152019381523,
0.0006237160414457321,
0.022082246840000153,
0.008984439074993134,
0.015655796974897385,
-0.00978319812566042,
0.008264634758234024,
0.02853124774992466,
-0.004719681106507778,
0.019525527954101562,
-0.006478357128798962,
-0.032465994358062744,
-0.016435062512755394,
-0.014088805764913559,
-0.04691152274608612,
-0.013617456890642643,
0.012906940653920174,
0.007200300227850676,
0.011309836991131306,
-0.011536790058016777,
-0.008233597502112389,
-0.008420350030064583,
0.005875219125300646,
0.017659597098827362,
0.018221765756607056,
-0.03704115003347397,
0.007411888800561428,
0.020844701677560806,
0.010763845406472683,
-0.003119424916803837,
0.0274118110537529,
0.02174142375588417,
0.015158705413341522,
0.0019158371724188328,
0.006524148862808943,
-0.016255676746368408,
-0.0008971497882157564,
0.006504145450890064,
0.008913682773709297,
0.005813797004520893,
0.026069574058055878,
0.0002939430996775627,
0.01347020547837019,
0.009670445695519447,
-0.00699811102822423,
-0.010404384694993496,
0.008271891623735428,
-0.008072268217802048,
0.02546597085893154,
0.02313881553709507,
-0.001344374381005764,
-0.027832087129354477,
-0.01620659977197647,
0.009522683918476105,
-0.0061018988490104675,
0.0006800182163715363,
-0.019590701907873154,
-0.003031093394383788,
-0.0033224569633603096,
0.024899326264858246,
-0.009383061900734901,
0.018056821078062057,
-0.007666826248168945,
-0.006116392556577921,
0.023810172453522682,
-0.02333476021885872,
0.005840662866830826,
0.01667073555290699,
-0.03347371518611908,
-0.01203523762524128,
-0.002625460270792246,
0.01865261420607567,
0.013999832794070244,
0.007882027886807919,
0.00639466755092144,
-0.022274266928434372,
0.012085063382983208,
-0.008238060399889946,
0.004163593053817749,
-0.021189723163843155,
-0.010690378025174141,
0.039518050849437714,
0.011311860755085945,
0.010519232600927353,
-0.010350826196372509,
-0.011259324848651886,
0.0048297857865691185,
0.014414451085031033,
-0.014577732421457767,
0.005282195750623941,
-0.020164113491773605,
-0.034766461700201035,
-0.009821397252380848,
0.0014574993401765823,
0.014098146930336952,
0.000026806723326444626
] | [
0.1921997219324112,
0.13122263550758362,
-0.2528294622898102,
-0.2729112505912781,
-0.07792884856462479,
0.26250341534614563,
0.5071315765380859,
-0.2897343635559082,
-0.05488859862089157,
-0.8790050745010376,
0.4118649363517761,
0.4180649518966675,
-0.5376824736595154,
-0.2564902901649475,
-0.07315941154956818,
0.10117186605930328,
0.49321600794792175,
0.24152739346027374,
-0.48457658290863037,
-0.11804219335317612,
-0.4718306362628937,
-0.14104199409484863,
-0.11402352899312973,
0.21907876431941986,
0.5712928771972656,
-0.49688786268234253,
0.3974754512310028,
-0.5512230396270752,
0.6574783325195312,
-0.3881356716156006,
0.030694685876369476,
0.2605826258659363,
-0.19197814166545868,
-0.3822440803050995,
-0.7662492990493774,
0.08744759857654572,
-0.5309939980506897,
0.406046986579895,
-0.19176697731018066,
-0.08823754638433456,
-0.49169427156448364,
-0.2450292706489563,
0.006729158107191324,
0.330363392829895,
-0.3478408455848694,
-0.21208007633686066,
-1.5674680471420288,
0.7140184044837952,
-0.3387744128704071,
0.24161431193351746,
0.19869397580623627,
-0.1138586476445198,
0.005606311839073896,
-0.03516729921102524,
-0.08499637246131897,
0.14486588537693024,
-0.46737444400787354,
-0.022896522656083107,
0.2236367166042328,
-0.29628998041152954,
0.4291854798793793,
0.18265511095523834,
0.21286271512508392,
0.12922760844230652,
-0.4244811236858368,
0.7525411248207092,
0.08845140784978867,
0.42233380675315857,
0.30892717838287354,
-0.3569539487361908,
0.2029772698879242,
-0.22922275960445404,
-0.12097493559122086,
-0.2242482602596283,
-0.16540542244911194,
0.14007844030857086,
0.04163272678852081,
-0.26407334208488464,
-0.3133763372898102,
0.06142442673444748,
-0.45034152269363403,
0.12304684519767761,
0.15362073481082916,
-0.3986319303512573,
0.7364518046379089,
0.08828654140233994,
0.1020183265209198,
0.6309324502944946,
-0.1796145737171173,
-0.02130734547972679,
0.19904755055904388,
-0.09794412553310394,
0.4948524832725525,
-0.03222345933318138,
0.31614023447036743,
0.12630455195903778,
-0.1109471470117569,
0.24356690049171448,
0.21954983472824097,
0.13563194870948792,
-0.18068799376487732,
0.08501653373241425,
-0.27895188331604004,
-0.4211748540401459,
-0.1201314702630043,
0.16288018226623535,
0.0334099680185318,
-0.4338655471801758,
-0.7839761972427368,
-0.04578561708331108,
-0.37109532952308655,
0.11983580142259598,
-0.21866683661937714,
-0.014069114811718464,
0.05360027775168419,
-0.2640901505947113,
0.3132948875427246,
-0.5201439261436462,
-0.03719690814614296,
-0.07031065225601196,
-0.3083447217941284,
0.8511363863945007,
-0.36965179443359375,
0.2858057916164398,
-0.5023303627967834,
-0.10579731315374374,
0.5451720356941223,
0.49585258960723877,
-0.21419988572597504,
0.25674256682395935,
-0.2583414614200592,
0.4151645004749298,
0.025336099788546562,
-0.003805336309596896,
0.04296444356441498,
0.2148522138595581,
-0.22833995521068573,
0.5548903942108154,
-0.1457168459892273,
-0.04867145046591759,
-0.23818738758563995,
-0.4777986407279968,
-0.06415151804685593,
-0.09653031080961227,
0.02209082990884781,
-0.6249729990959167,
0.1731627732515335,
0.09793224930763245,
-0.32444310188293457,
-0.07924754172563553,
-0.044904161244630814,
-0.30611342191696167,
-0.6586417555809021,
0.1623287796974182,
0.015425682999193668,
0.3253432512283325,
-0.08740010857582092,
0.012837340123951435,
0.07133287936449051,
0.393475204706192,
0.13802197575569153,
0.23723161220550537,
-0.2014780342578888,
-0.3014072775840759,
0.16277799010276794,
0.09987742453813553,
0.3898937702178955,
0.3185616135597229,
0.4401925206184387,
0.25097817182540894,
-0.2623995840549469,
-0.26081106066703796,
-0.2256639003753662,
-0.15141916275024414,
-0.31138771772384644,
-0.0038094320334494114,
0.44279780983924866,
0.16699154675006866,
-0.019602658227086067,
0.1432560235261917,
-0.5375977754592896,
-0.3912679851055145,
-0.1820465624332428,
-0.6537519693374634,
1.0104491710662842,
-0.043307479470968246,
0.09079517424106598,
0.03710583969950676,
0.05601530522108078,
0.14195075631141663,
0.10492713749408722,
-0.2934870719909668,
0.06188399717211723,
-0.41234520077705383,
1.485237956047058,
-0.4130612015724182,
-0.26817095279693604,
1.3680468797683716,
0.447508841753006,
0.2180827409029007,
0.4729364812374115,
0.16902239620685577,
0.4409218430519104,
0.034854162484407425,
-0.41952115297317505,
-0.1094934493303299,
-0.17839322984218597,
0.07395149767398834,
0.08332393318414688,
-0.07173903286457062,
0.23506183922290802,
0.23893292248249054,
-0.23153728246688843,
-0.25707167387008667,
0.32613927125930786,
0.4574377238750458,
-0.15292206406593323,
0.17500805854797363,
-0.28993791341781616,
-0.15610499680042267,
0.4109985828399658,
-0.5627269148826599,
0.30549412965774536,
0.5619116425514221,
0.09743823856115341,
0.42152082920074463,
0.5476387739181519,
-0.1782871037721634,
1.1260238885879517,
-0.6181831955909729,
0.37531715631484985,
-0.6341875791549683,
0.463242769241333,
-0.5555856823921204,
-0.2216028869152069,
0.09801767021417618,
0.23048226535320282,
-0.21507889032363892,
-0.6155520081520081,
0.3470109701156616,
0.46486806869506836,
0.7191801071166992,
-0.8529070615768433,
0.19703105092048645,
0.014927322044968605,
-0.5708147287368774,
-0.023091837763786316,
-0.03319312259554863,
-0.5833084583282471,
0.11993976682424545,
-0.45088011026382446,
0.33180978894233704,
0.5202233791351318,
-0.376909077167511,
0.6002518534660339,
-0.3540479838848114,
-0.29624125361442566,
-0.25251856446266174,
0.3948507308959961,
-0.3217928111553192,
-0.05091940611600876,
0.2095268964767456,
0.16321898996829987,
0.5699066519737244,
0.1212037056684494,
-0.7081359028816223,
-0.7983754277229309,
-0.24534204602241516,
0.7048805952072144,
0.7769928574562073,
1.21714186668396,
0.22497211396694183,
-0.2389095425605774,
-0.02470574714243412,
0.2103879600763321,
-0.6574286222457886,
0.33947938680648804,
0.7981229424476624,
-0.16020840406417847,
-0.20600324869155884,
-0.23667019605636597,
0.3932654559612274,
0.37964025139808655,
-0.5868287682533264,
-0.11306774616241455,
-0.2268550544977188,
-0.37042760848999023,
-0.3939148783683777,
-0.7538206577301025,
-0.06572410464286804,
-0.12937156856060028,
0.2263135015964508,
-0.4329740107059479,
-0.343755304813385,
0.4474285840988159,
0.4291134476661682,
-0.014443043619394302,
0.4791046679019928,
0.3395737409591675,
-0.05135102942585945,
-0.3988626301288605,
0.07304203510284424,
-0.5309320092201233,
0.055356286466121674,
-0.255156546831131,
-0.0007134074112400413,
-0.21872951090335846,
-0.0060708834789693356,
-5.954007625579834,
-0.18307484686374664,
0.2231277972459793,
-0.28822600841522217,
0.03383568301796913,
0.09950195997953415,
1.2188204526901245,
0.11070206016302109,
0.5891677141189575,
0.3427949845790863,
0.03153657168149948,
0.36883705854415894,
-0.27683618664741516,
-0.029032260179519653,
-0.38580822944641113,
0.3199901580810547,
-0.5456360578536987,
0.16345033049583435,
0.0783357247710228,
-0.01820305548608303,
0.04669533297419548,
-0.16130372881889343,
-0.16474558413028717,
0.6729748249053955,
0.010807584971189499,
-0.3335575759410858,
-0.8454456329345703,
0.08470179885625839,
0.08480202406644821,
0.1440858542919159,
0.3433564305305481,
-0.835297703742981,
-0.08625315874814987,
0.07052167505025864,
-0.060230545699596405,
0.32253456115722656,
0.468902587890625,
-0.10119938850402832,
-0.052675142884254456,
-0.6843817830085754,
-0.10297377407550812,
-0.05822186917066574,
-0.5778022408485413,
0.0029342195484787226,
-0.1745993047952652,
0.03581394627690315,
0.07950963079929352,
0.2797536253929138,
-0.02144872583448887,
0.6227339506149292,
-0.33896997570991516,
0.022015372291207314,
0.3491419553756714,
0.33353960514068604,
0.3023796081542969,
-0.08943735808134079,
-0.29120904207229614,
0.005492100957781076,
-0.15347138047218323,
-0.14192864298820496,
-0.3894822895526886,
-0.030767293646931648,
-0.22202669084072113,
-0.7763148546218872,
0.7286345362663269,
-0.05431581661105156,
-0.6681182980537415,
-0.32548099756240845,
0.2704984247684479,
0.2805022597312927,
0.02420445717871189,
0.3783857822418213,
-0.14166006445884705,
-0.9056630730628967,
0.07994727045297623,
-0.5258101224899292,
0.3366663157939911,
-0.0647512748837471,
0.2904477119445801,
-0.4667501747608185,
-0.33907803893089294,
0.20939859747886658,
-0.17359469830989838,
0.127267986536026,
0.05375194549560547,
0.2927665114402771,
-0.32585206627845764,
-0.15285003185272217,
-0.3823361396789551,
0.09691621363162994,
0.9003811478614807,
-0.14396989345550537,
-0.10621362179517746,
0.4919477701187134,
0.2550027072429657,
0.6296582818031311,
0.12433020770549774,
0.3344108760356903,
0.6502478122711182,
-0.29599183797836304,
0.7476799488067627,
0.09000590443611145,
-0.3363129496574402,
-0.5503748059272766,
-0.2056673914194107,
0.33788764476776123,
-0.7599624991416931,
0.012569977901875973,
0.9873376488685608,
-0.7182577848434448,
0.018352875486016273,
-0.052177246659994125,
-0.3984408974647522,
-0.1755790263414383,
0.27052539587020874,
0.13928447663784027,
0.37312671542167664,
0.01726178452372551,
0.9810921549797058,
-0.07696138322353363,
0.5408510565757751,
0.16985340416431427,
-0.5764191150665283,
0.4904075860977173,
0.41318807005882263,
-0.3276747465133667,
0.3124515116214752,
0.5707980394363403,
-0.7146894335746765,
-0.42041853070259094,
0.5375060439109802,
0.2359003871679306,
-0.44298940896987915,
0.34383225440979004,
0.21320022642612457,
-0.11797817051410675,
-0.026561398059129715,
-0.38440150022506714,
0.1053822934627533,
0.04011581465601921,
-0.23976212739944458,
-0.28714385628700256,
-0.2297876477241516,
0.13460539281368256,
0.13777081668376923,
-0.22596310079097748,
-0.09745664149522781,
-0.11864528805017471,
-0.23072855174541473,
-0.4213925302028656,
0.47995439171791077,
-0.2893814444541931,
0.004912277217954397,
0.04527408629655838,
-0.8672007322311401,
0.38460174202919006,
0.7512001991271973,
-0.4146629869937897,
-0.20778699219226837,
-0.3169112801551819,
0.2884089946746826,
0.1962134838104248,
-0.9066726565361023,
-0.00603607390075922,
-0.25577253103256226,
-0.29667404294013977,
-0.4085162878036499,
-0.43523508310317993,
0.19462870061397552,
0.24682578444480896,
-0.0503111407160759,
-0.45852720737457275,
-0.34552639722824097,
-0.40706363320350647,
0.22824324667453766,
-0.17748062312602997,
-0.28689825534820557,
0.39551717042922974,
-0.412885457277298,
-0.2402793914079666,
0.09907183051109314,
-0.36769241094589233,
-0.7735852599143982,
0.2278134971857071,
0.7419289946556091,
-0.06089101731777191,
-0.09907006472349167,
-0.19553469121456146,
-0.7851551175117493,
-0.06989452987909317,
0.05561757832765579,
0.42916443943977356,
0.46976885199546814,
-0.1005302369594574,
-0.15703821182250977,
0.14610172808170319,
-0.2023874670267105,
0.31609994173049927,
0.21017248928546906,
-0.17070160806179047,
-0.012223630212247372,
0.2603585422039032,
-0.4613266885280609,
0.23896723985671997,
0.0433957464993,
0.09298790991306305,
-0.382648229598999,
-0.028875667601823807,
-0.19733202457427979,
-0.08372487127780914,
0.16517885029315948,
-0.3377031087875366,
0.09869757294654846,
0.47453561425209045,
0.18556074798107147,
0.19621920585632324,
-0.3737369477748871,
-0.03376392275094986,
0.1476103812456131,
0.39529916644096375,
0.07010460644960403,
0.01437425147742033,
-0.3329588770866394,
0.013765500858426094,
0.0412917360663414,
-0.09512407332658768,
0.3058241605758667,
-0.7511336803436279,
-0.10156445950269699,
0.2753661870956421,
0.13671784102916718,
0.09661045670509338,
0.1549096554517746,
-0.01639009267091751,
-0.810231626033783,
-0.38593438267707825,
0.020283924415707588,
0.3091857433319092,
-0.15377794206142426,
0.8266385793685913,
0.21885326504707336,
0.3590676486492157,
0.21379433572292328,
0.19578218460083008,
0.10620872676372528,
0.2252391278743744,
0.2638171911239624,
-0.3029980957508087,
-0.24353986978530884,
0.2380954772233963,
0.07900118827819824,
-0.024366695433855057,
-0.1906910389661789,
0.4538848400115967,
0.4211258888244629,
0.20205256342887878,
-0.33932361006736755,
-0.1804659217596054,
-0.27674564719200134,
-0.24933737516403198,
0.10523978620767593,
-0.1726028174161911,
-0.6646115183830261,
0.0057902103289961815,
-0.1311097890138626,
-0.06909503042697906,
-0.4243616759777069,
-0.5362540483474731,
0.5369346141815186,
-0.3171823024749756,
-0.02429116517305374,
-0.34251704812049866,
0.77484530210495,
0.5769637227058411,
0.046287473291158676,
0.19728265702724457,
-0.002627501729875803,
0.35587748885154724,
0.1203121617436409,
0.20283156633377075,
0.00205755652859807,
-0.576203465461731,
0.563674807548523,
-0.40362077951431274,
0.3341332674026489,
-0.9292303323745728,
-0.12567675113677979,
-0.8703286051750183,
0.060493797063827515,
-0.29104530811309814,
-0.2982444763183594,
0.11140379309654236,
-0.6739834547042847,
-0.3257732689380646,
-0.11035823822021484,
0.45833200216293335,
0.06375829875469208,
0.20602957904338837,
-0.16704018414020538,
-0.3161972165107727,
-0.41714367270469666,
0.7135451436042786,
0.40019774436950684,
-0.15109257400035858,
-0.1702001988887787,
0.12592144310474396,
0.25508829951286316,
0.25580519437789917,
-0.6538758873939514,
0.07444926351308823,
-0.21380974352359772,
-0.31923237442970276,
0.40290507674217224,
0.06825371086597443,
-0.850161075592041,
0.2554275095462799,
0.20796974003314972,
-0.5588749647140503,
0.311892032623291,
0.023427743464708328,
0.16864092648029327,
0.6123579740524292,
0.14260023832321167,
-0.2427457720041275,
0.25447529554367065,
0.5552136898040771,
-0.1007528007030487,
0.1840210258960724,
-0.17957502603530884,
0.4852156639099121,
0.8225674629211426,
0.2526600658893585,
-0.05440370738506317,
0.19776345789432526,
0.5041851997375488,
0.4431547224521637,
0.2533003091812134,
-0.4783356785774231,
-0.36142173409461975,
0.294120728969574,
0.7063186168670654,
0.5434278845787048,
0.17966575920581818,
-0.4912465512752533,
-0.5520063042640686,
0.2899530827999115,
-0.18324877321720123,
0.812637448310852,
-0.046947456896305084,
-0.10233056545257568,
0.5936387777328491,
-0.55446857213974,
0.12629738450050354,
0.4958975315093994,
-0.3377988040447235,
0.23692533373832703,
0.8121531009674072,
-0.37270304560661316,
-0.5083735585212708,
-0.1037239134311676,
0.011868433095514774,
0.15036128461360931,
0.6732960343360901,
0.35298600792884827,
0.12019740790128708,
0.40135228633880615,
0.29662710428237915,
0.0472230426967144,
0.1584557145833969,
-0.11730318516492844,
0.01204813551157713,
0.07635899633169174,
-0.13070087134838104,
0.22776184976100922,
0.4271337687969208,
-0.08075779676437378,
0.009910640306770802,
0.06236898526549339,
-0.38180387020111084,
0.1343173086643219,
-0.037764158099889755,
-0.18481230735778809,
-0.35108962655067444,
-0.9113145470619202,
-0.15063923597335815,
-0.021923920139670372,
-0.43921834230422974,
0.13097792863845825,
-0.18872717022895813,
0.2597929537296295,
-0.40709179639816284,
-0.858331024646759,
0.8243643641471863,
0.28726625442504883,
-0.06847433000802994,
0.3387051224708557,
-0.10794805735349655,
0.3943726122379303,
0.1811170130968094,
0.0782289132475853,
-0.1994912177324295,
0.6011331677436829,
-0.3099340498447418,
-0.05485527589917183,
-0.3783226013183594,
0.8961737155914307,
-0.3397587537765503,
-0.27752700448036194,
-0.1100023090839386,
0.08092759549617767,
1.2927098274230957,
0.42832982540130615,
-0.24189570546150208,
-0.3646753132343292,
0.13216975331306458,
0.30684134364128113,
0.4373498857021332,
-0.37430939078330994,
-0.21101100742816925,
-0.24595008790493011,
-0.4439461827278137,
-0.5157416462898254,
0.13591890037059784,
0.2562964856624603,
-0.5351003408432007,
-0.13835594058036804,
0.3616897463798523,
0.3600028455257416,
-0.27105581760406494,
0.4271871745586395,
0.013424068689346313,
-0.07921864837408066,
-0.6327934265136719,
0.3086739480495453,
-0.3827155828475952,
-0.316310852766037,
-0.09929472953081131,
0.02356431819498539,
0.4747547209262848,
0.19793349504470825,
0.49921107292175293,
-0.4916665852069855,
0.2491127848625183,
0.23788611590862274,
0.000213834093301557,
-0.08849304914474487,
-0.17831890285015106,
-0.4709223806858063,
-0.4779082238674164,
0.24592727422714233,
0.0071327886544167995,
-0.6147792935371399,
-0.40741831064224243,
0.5380582213401794,
-0.5090349316596985,
0.08743193745613098,
-0.04016668722033501,
-0.4162198305130005,
-0.28413522243499756,
-0.17392142117023468
] |
In the present study, a novel series of 4-(2-aminophenyl)morpholines were synthesized and characterized by IR, (1)H-NMR, (13)C NMR and mass spectral analysis. The synthesized compounds were screened for analgesic (100 and 200 mg/kg), antiinflammatory (200 and 400 mg/kg), antibacterial (Bacillus subtilis, Bacillus cereus, Staphylococcus epidermidis, Staphylococcus aureus, Klebsiella pneumoniae, Pseudomonas aeruginosa and Escherichia coli) and antifungal (Candida albicans and Aspergillus niger) activities. The minimum inhibitory concentrations of the compounds were also ascertained by agar streak dilution method. N-benzylidine-2-morpholoino benzenamine (1) and N-(3-nitro benzylidine)-2-morpholino benzenamine (3) exhibited significant analgesic, antiinflammatory and antimicrobial activities. | [
0.0178383756428957,
0.013209854252636433,
-0.012975966557860374,
0.02232942171394825,
-0.020346542820334435,
0.01906808838248253,
0.007922478020191193,
-0.0021355915814638138,
-0.00844272319227457,
-0.005764254368841648,
-0.006120897829532623,
0.007049978245049715,
-0.02294876053929329,
-0.00225328397937119,
0.0030552237294614315,
-0.008362025022506714,
-0.01945488527417183,
0.035106707364320755,
0.0057297516614198685,
0.0046830070205032825,
-0.003746753092855215,
-0.017312807962298393,
0.00816346611827612,
0.011151690036058426,
0.011064505204558372,
-0.007372171618044376,
0.01911942847073078,
-0.018897883594036102,
-0.010755867697298527,
0.017490863800048828,
-0.005438422318547964,
0.007641670294106007,
0.01669199764728546,
0.004006489180028439,
0.0021002613939344883,
0.019971199333667755,
-0.0033952004741877317,
0.018870802596211433,
0.004618817009031773,
-0.004537391010671854,
-0.01812746375799179,
-0.01127277035266161,
0.00237270537763834,
-0.014513248577713966,
-0.008377653546631336,
-0.01115110982209444,
-0.007014338858425617,
-0.008889012038707733,
0.005287589505314827,
0.006056439131498337,
-0.010798892006278038,
0.001122867688536644,
-0.01832202821969986,
-0.0015158455353230238,
-0.004938327707350254,
0.015355147421360016,
0.015031043440103531,
-0.0028258536476641893,
-0.016290264204144478,
0.0012628263793885708,
0.026103675365447998,
0.02425239607691765,
-0.005381159950047731,
-0.004909496288746595,
0.012522971257567406,
-0.06707696616649628,
0.026437874883413315,
0.0036104279570281506,
-0.01141466572880745,
-0.001569022424519062,
-0.029288606718182564,
0.011261669918894768,
-0.037693366408348083,
-0.006894107908010483,
-0.012374634854495525,
0.003185718320310116,
-0.011070945300161839,
0.01586299017071724,
-0.0017796787433326244,
-0.009869704954326153,
0.004352370277047157,
0.00941690243780613,
0.006764252204447985,
-0.003359816735610366,
-0.01591719500720501,
0.010994541458785534,
-0.02873440459370613,
0.009083526208996773,
0.013799289241433144,
-0.0016599055379629135,
0.0059432536363601685,
0.013103129342198372,
-0.0314481295645237,
-0.00047140149399638176,
0.01154567115008831,
0.03117818385362625,
0.009066667407751083,
0.014608718454837799,
0.012063365429639816,
0.0035483096726238728,
-0.027331151068210602,
0.017429079860448837,
0.014056130312383175,
-0.025462372228503227,
-0.0041379802860319614,
0.0035786768421530724,
-0.006101508624851704,
0.017901116982102394,
0.013517294079065323,
0.0038593702483922243,
0.0006367038004100323,
0.01007617823779583,
-0.028763068839907646,
0.0131867416203022,
-0.0014242184115573764,
-0.01627286523580551,
-0.02182714454829693,
0.023746920749545097,
0.010251285508275032,
-0.014421881176531315,
-0.008312642574310303,
-0.010200556367635727,
-0.006484631914645433,
0.0017217285931110382,
0.0033432813361287117,
0.0033388587180525064,
-0.013055403716862202,
-0.0036178920418024063,
0.014771795831620693,
0.0021567975636571646,
-0.006403816398233175,
0.0028939349576830864,
-0.0013035074807703495,
-0.0026638307608664036,
0.002428054343909025,
-0.0011359838536009192,
0.0019028149545192719,
-0.014264141209423542,
-0.01261400617659092,
0.0029398808255791664,
0.003575267270207405,
0.005937485024333,
-0.00013063638471066952,
0.010416638106107712,
0.004573360085487366,
-0.0030022249557077885,
-0.0006717117503285408,
-0.008412564173340797,
0.02342393808066845,
-0.005068437661975622,
-0.0004830013494938612,
-0.02337707206606865,
-0.000380147248506546,
-0.014255192130804062,
-0.0029930733144283295,
0.021709877997636795,
-0.01117341686040163,
-0.013572651892900467,
-0.01057252287864685,
-0.003649260615929961,
0.002268596552312374,
-0.0011587482877075672,
0.011089731007814407,
0.008765150792896748,
-0.0021195949520915747,
0.005353422835469246,
-0.007877010852098465,
-0.0038607832975685596,
0.0006075066048651934,
0.0027288533747196198,
0.008051595650613308,
0.0073299407958984375,
0.0057743992656469345,
0.006027457304298878,
0.03019355982542038,
-0.00435301847755909,
0.0019881189800798893,
0.003481754334643483,
-0.021204188466072083,
0.06668827682733536,
0.03187538683414459,
0.018609944730997086,
0.025057179853320122,
0.015328575856983662,
0.011657223105430603,
-0.00951472856104374,
0.002135884016752243,
0.003990968223661184,
-0.004200031515210867,
0.009921264834702015,
0.04393419623374939,
0.007047598250210285,
0.018130987882614136,
-0.014087658375501633,
-0.0036795218475162983,
0.00161645223852247,
0.011143827810883522,
0.007596720941364765,
-0.008406313136219978,
-0.01710250787436962,
0.019750649109482765,
-0.005364868324249983,
0.032144635915756226,
-0.0011917706578969955,
0.012376508675515652,
0.006252148188650608,
0.01762438379228115,
0.007856488227844238,
-0.015719301998615265,
0.024054352194070816,
0.017819955945014954,
-0.032884251326322556,
0.007541850209236145,
-0.007432373706251383,
-0.009731553494930267,
0.000529794255271554,
-0.010871275328099728,
0.005789500195533037,
-0.0071489764377474785,
-0.010962973348796368,
-0.0009636464528739452,
-0.0027294231113046408,
-0.02244061604142189,
0.0021063750609755516,
-0.0010682009160518646,
-0.01820286735892296,
0.017690401524305344,
0.004217600449919701,
-0.001471028313972056,
-0.008174561895430088,
-0.011487077921628952,
-0.0019368482753634453,
-0.012249484658241272,
-0.011256570927798748,
0.034410081803798676,
0.01640431582927704,
0.012613602913916111,
0.0034823159221559763,
0.0035137166269123554,
-0.011784187518060207,
0.001997911836951971,
0.018643267452716827,
-0.01236875168979168,
-0.01143655739724636,
-0.010188693180680275,
0.002062225015833974,
0.012628309428691864,
-0.014062272384762764,
0.013090208172798157,
0.00202021561563015,
0.00673567783087492,
0.00298183411359787,
-0.008534746244549751,
-0.011843713000416756,
0.0008235317654907703,
-0.004672727547585964,
-0.010044005699455738,
-0.004179789684712887,
0.023905396461486816,
0.001446332549676299,
0.005778513383120298,
0.0031334715895354748,
0.01618996448814869,
-0.0070450277999043465,
-0.006621861830353737,
0.004698257893323898,
-0.0054169707000255585,
0.005253197625279427,
0.011384621262550354,
-0.01726917363703251,
0.009558466263115406,
-0.007177660241723061,
-0.0007862746715545654,
-0.08210483938455582,
-0.0018891633953899145,
0.0014925473369657993,
-0.007750600576400757,
0.002985208062455058,
-0.005880110897123814,
-0.0016072818543761969,
0.0026869107969105244,
-0.008586621843278408,
0.029072660952806473,
-0.004934570752084255,
0.006915257312357426,
-0.008858989924192429,
0.0073720673099160194,
0.010848017409443855,
-0.0035656169056892395,
0.006459671072661877,
0.010426679626107216,
-0.0039295051246881485,
-0.017170768231153488,
-0.008725706487894058,
-0.003966213669627905,
0.005924534052610397,
0.010099951177835464,
0.010151474736630917,
0.017332781106233597,
0.00270317355170846,
-0.001422938541509211,
-0.011930529028177261,
0.021789629012346268,
-0.006025784648954868,
-0.0010511733125895262,
0.01084018126130104,
-0.002984718419611454,
0.010717218741774559,
0.015578827820718288,
-0.017483357340097427,
-0.016614381223917007,
-0.00860459916293621,
0.008838801644742489,
-0.022212911397218704,
0.0019802951719611883,
0.011053874157369137,
-0.017543550580739975,
0.004545559640973806,
0.02233121171593666,
-0.009224796667695045,
0.005935600958764553,
0.015296372584998608,
0.013379909098148346,
-0.0012376834638416767,
-0.001588393934071064,
0.0017959289252758026,
0.016463810577988625,
-0.011620225384831429,
0.029614189639687538,
-0.005573282949626446,
0.015066764317452908,
-0.0035674828104674816,
0.00827124621719122,
0.004538633394986391,
0.017032362520694733,
0.004351986572146416,
0.006674167700111866,
-0.015275505371391773,
0.0095856674015522,
0.006578429602086544,
-0.018869468942284584,
-0.011030338704586029,
0.02302306890487671,
0.0009397878311574459,
0.0049750483594834805,
-0.01088738813996315,
-0.007033181376755238,
0.0035893013700842857,
-0.015404894948005676,
-0.012650500982999802,
-0.0034938096068799496,
-0.0416201651096344,
-0.010868821293115616,
0.002041538944467902,
-0.0013411827385425568,
0.026915617287158966,
0.008783388882875443,
-0.0264141745865345,
-0.009859554469585419,
0.00845453143119812,
-0.00781390443444252,
0.013913663104176521,
-0.008439477533102036,
-0.0004753465764224529,
0.01377648115158081,
0.008477284573018551,
0.013171538710594177,
0.005956428591161966,
-0.01941056177020073,
-0.018695203587412834,
0.005695851985365152,
0.011757542379200459,
0.007656806148588657,
-0.003404357936233282,
-0.004624537657946348,
-0.012097486294806004,
-0.0004627198213711381,
-0.018398500978946686,
0.00319055188447237,
-0.008235577493906021,
-0.00436604768037796,
-0.010670360177755356,
-0.0005688217934221029,
0.0021905554458498955,
0.0043258341029286385,
0.0013901758939027786,
0.02833462506532669,
0.006623112130910158,
0.01110463123768568,
-0.021311499178409576,
0.0032188226468861103,
0.07317125052213669,
0.0016225960571318865,
-0.004043744411319494,
-0.017095793038606644,
0.000027955742552876472,
-0.007946135476231575,
-0.018750764429569244,
0.024345535784959793,
-0.0015909140929579735,
0.010440286248922348,
0.010891422629356384,
0.011639585718512535,
0.004238491877913475,
0.009453782811760902,
-0.014585085213184357,
-0.0009266658453270793,
-0.004384580999612808,
-0.012691281735897064,
0.011961044743657112,
0.03500335291028023,
0.003741317894309759,
-0.01813420280814171,
-0.00916980765759945,
-0.001094816718250513,
0.012264102697372437,
0.00365048972889781,
0.0035498798824846745,
-0.010701758787035942,
-0.010125046595931053,
0.00820139143615961,
0.016036393120884895,
0.005432984791696072,
-0.010188484564423561,
-0.009299181401729584,
0.015414098277688026,
0.020981037989258766,
-0.009707494638860226,
0.011906247586011887,
-0.007277379278093576,
-0.022713489830493927,
0.027126632630825043,
-0.007134694140404463,
0.0076562874019145966,
0.009000848047435284,
-0.02139681950211525,
0.00851355865597725,
-0.002385298488661647,
-0.005139842629432678,
0.003758863778784871,
-0.016245847567915916,
0.005671094171702862,
0.0020346969831734896,
0.015837591141462326,
0.014618911780416965,
-0.011425100266933441,
0.009999261237680912,
0.027604803442955017,
-0.008101360872387886,
-0.007745413575321436,
-0.021829184144735336,
-0.018160995095968246,
0.0232020765542984,
-0.008191011846065521,
0.011286627501249313,
0.006557633634656668,
-0.012660717591643333,
-0.01690409705042839,
-0.0030410178005695343,
0.004519918002188206,
-0.005074187181890011,
0.005693348124623299,
0.002431934466585517,
-0.019971124827861786,
-0.002057823818176985,
-0.017369110137224197,
-0.014999251812696457,
-0.01520212646573782,
0.006570472382009029,
0.02299177460372448,
-0.008252579718828201,
0.0023489794693887234,
0.031519338488578796,
-0.0012853285297751427,
-0.022797144949436188,
0.018090441823005676,
-0.03309829533100128,
-0.03708042576909065,
-0.07571226358413696,
-0.003038502996787429,
0.011185652576386929,
-0.0016116967890411615,
-0.0052506220526993275,
0.02666405960917473,
-0.006835956126451492,
-0.0025202655233442783,
0.009100736118853092,
-0.0008763505611568689,
0.017706969752907753,
-0.009385724551975727,
0.005350892432034016,
-0.00716647831723094,
0.010492546483874321,
0.006491093896329403,
0.0023567923344671726,
0.008459960110485554,
-0.01549034658819437,
-0.016241274774074554,
-0.00874907337129116,
0.020262762904167175,
-0.004077205900102854,
0.003655949141830206,
-0.011002479121088982,
-0.08201272785663605,
-0.011766663752496243,
-0.008587472140789032,
0.004148577339947224,
-0.010666662827134132,
-0.005193640477955341,
0.01817982643842697,
-0.009046959690749645,
-0.023747321218252182,
-0.012321359477937222,
-0.010005069896578789,
-0.0009386646561324596,
0.0077638644725084305,
-0.00431867316365242,
-0.008733473718166351,
-0.004248911049216986,
0.0136346984654665,
-0.010117137804627419,
-0.013274776749312878,
-0.005155491642653942,
-0.019045064225792885,
0.028493773192167282,
-0.006190313026309013,
0.0036169078666716814,
-0.0015345789724960923,
-0.00000820215791463852,
-0.008874530903995037,
0.009902402758598328,
0.004445366561412811,
-0.02195083722472191,
-0.025914393365383148,
-0.00944528914988041,
-0.017659001052379608,
0.016900891438126564,
-0.0010884907096624374,
-0.023418329656124115,
0.005614706315100193,
-0.018463153392076492,
-0.01234830915927887,
-0.0005125817842781544,
-0.003090938786044717,
0.012630041688680649,
0.002387193962931633,
0.005816280376166105,
-0.003871805965900421,
-0.016344446688890457,
0.0060979644767940044,
-0.01284499280154705,
0.002961961552500725,
0.03175204247236252,
0.009587584063410759,
-0.006282046437263489,
0.015782205387949944,
0.012053048238158226,
-0.0070567987859249115,
0.02300289459526539,
-0.003095593536272645,
0.005252002738416195,
0.0033979404252022505,
0.00752737233415246,
-0.012288078665733337,
-0.008490358479321003,
0.0078058987855911255,
0.0718679130077362,
-0.022763535380363464,
-0.00835280679166317,
-0.006290079560130835,
-0.0038867276161909103,
0.0050140139646828175,
-0.011322274804115295,
0.0013668118044734001,
-0.02486550807952881,
-0.006781392730772495,
0.017258163541555405,
-0.0029152450151741505,
0.012773655354976654,
0.009249383583664894,
-0.002080830279737711,
0.003930556587874889,
-0.018400806933641434,
0.006439813878387213,
-0.00275158672593534,
-0.005590682849287987,
-0.021156061440706253,
0.021131739020347595,
-0.003279539756476879,
0.00437742518261075,
0.01139788143336773,
-0.023571811616420746,
0.0030808807350695133,
0.006740759592503309,
-0.010376261547207832,
0.029432859271764755,
-0.016139168292284012,
-0.01298744697123766,
0.005623448174446821,
-0.009187443181872368,
0.009271674789488316,
0.013819899410009384,
-0.007477856241166592,
0.012762720696628094,
-0.009666798636317253,
-0.015182998031377792,
0.0008353292942047119,
0.007814045995473862,
0.009051717817783356,
-0.020508091896772385,
-0.010014781728386879,
-0.003388183657079935,
-0.002205559052526951,
0.0008724738145247102,
-0.016225291416049004,
-0.010322131216526031,
0.0067299734801054,
0.008037757128477097,
0.014528390020132065,
-0.012269679456949234,
-0.008388685062527657,
0.012099919840693474,
-0.013426574878394604,
0.012058469466865063,
-0.007339137140661478,
-0.022936277091503143,
0.00015066610649228096,
-0.00757230818271637,
0.015594551339745522,
-0.019723784178495407,
0.009250972419977188,
0.010338937863707542,
-0.0038770351093262434,
-0.017939837649464607,
-0.015272971242666245,
0.011913519352674484,
-0.0182830560952425,
0.0006918753497302532,
0.0029505244456231594,
0.018068784847855568,
0.027323121204972267,
0.010675780475139618,
0.029267536476254463,
0.0031907139346003532,
0.02574954926967621,
0.0098345298320055,
-0.005688626319169998,
0.02132071740925312,
0.009371019899845123,
-0.0006470661610364914,
-0.0028680756222456694,
0.0031791948713362217,
0.02262427844107151,
0.011926284059882164,
0.005401247180998325,
0.0018160847248509526,
0.002875083591789007,
0.006022966466844082,
0.0017923252889886498,
0.03298461437225342,
0.0018181202467530966,
0.033518657088279724,
-0.005250510759651661,
0.007838201709091663,
-0.0015742587856948376,
0.0036727366968989372,
-0.006815391127020121,
0.01835082471370697,
0.0015508721116930246,
-0.0023706364445388317,
-0.004882568493485451,
0.013400848954916,
-0.010415098629891872,
0.029034271836280823,
-0.016006801277399063,
-0.0064974380657076836,
0.00035783834755420685,
-0.005012317560613155,
-0.006117756478488445,
0.009936261922121048,
0.0032420121133327484,
-0.017220962792634964,
0.007360880263149738,
-0.01608653925359249,
0.0006735837087035179,
-0.01508584339171648,
-0.011477191932499409,
0.004008364863693714,
-0.008964421227574348,
-0.002305380068719387,
0.006063097156584263,
-0.012009937316179276,
-0.006671299692243338,
0.021128809079527855,
0.004967816174030304,
0.005711288657039404,
0.025205591693520546,
-0.0018184604123234749,
0.004117036238312721,
-0.01465667225420475,
-0.013697803020477295,
-0.0020256477873772383,
0.007898367010056973,
0.017475508153438568,
0.017138049006462097,
-0.028620757162570953,
0.007498973049223423,
-0.008699319325387478,
0.0021442470606416464,
-0.018933715298771858,
0.00588498217985034,
-0.004966442473232746,
0.012079478241503239,
0.015428588725626469,
0.011586477980017662,
0.004039997700601816,
0.00005366327241063118,
-0.00028030527755618095,
0.007584192790091038,
-0.006232123821973801,
-0.009091373533010483,
0.006432808004319668,
0.002147066406905651,
-0.00024547730572521687,
-0.01603081077337265,
-0.0019849329255521297,
0.005134716629981995,
0.0049828458577394485,
-0.000021433690562844276,
-0.005406276788562536,
-0.0037190252915024757,
-0.020049912855029106,
0.011869730427861214,
0.03572960942983627,
-0.011108958162367344,
-0.000425602775067091,
0.005840787664055824,
0.01337708905339241,
0.0035579197574406862,
0.009857473894953728,
-0.0003032957320101559,
-0.00809583067893982,
-0.014323249459266663,
-0.006775976158678532,
0.010433611460030079,
0.004303001333028078,
0.01817410998046398,
-0.009321453049778938,
0.025812434032559395,
-0.012270652689039707,
0.015563180670142174,
0.005375622306019068,
-0.01086864247918129,
0.0018070018850266933,
-0.0035282704047858715,
0.009251528419554234,
-0.0068702418357133865,
-0.017605161294341087,
-0.012433596886694431,
0.004587575327605009,
-0.0027053505182266235,
0.0010742835002020001,
0.0027463191654533148,
-0.0218576118350029,
0.0010484890080988407,
-0.0024109201040118933,
0.00008262787014245987,
-0.011104585602879524
] | [
0.2884444296360016,
0.31167712807655334,
0.03404153510928154,
-0.10842957347631454,
-0.1209644302725792,
0.22437159717082977,
0.34539690613746643,
-0.5293789505958557,
-0.22784602642059326,
-0.2589211165904999,
-0.008688189089298248,
0.19271209836006165,
-0.41631126403808594,
0.44460412859916687,
0.4219502806663513,
1.2161215543746948,
0.24375751614570618,
0.6246301531791687,
-0.3018399775028229,
-0.6059375405311584,
-0.1071401834487915,
-0.6466441750526428,
0.3058398962020874,
-0.17871598899364471,
0.19529804587364197,
0.23902392387390137,
0.34693625569343567,
0.1994401216506958,
0.2990800440311432,
-0.25802314281463623,
0.10078795254230499,
0.8613309264183044,
0.020684020593762398,
0.02370285429060459,
0.08087050914764404,
0.06942800432443619,
0.18638882040977478,
0.10091471672058105,
0.27445587515830994,
-0.7298851013183594,
-0.42000195384025574,
-0.12097305804491043,
-0.05722080171108246,
0.4094191789627075,
-0.4717867970466614,
0.1078629270195961,
-0.9950992465019226,
0.5730920433998108,
-0.13301995396614075,
0.11278700083494186,
0.5746644735336304,
-0.07882395386695862,
0.6407155394554138,
-0.054232753813266754,
-0.16786734759807587,
0.4225679039955139,
-0.733450174331665,
-0.09275881201028824,
0.3716549873352051,
-0.39215779304504395,
0.20151478052139282,
0.047008804976940155,
-0.004269468132406473,
0.39402085542678833,
0.21125160157680511,
0.8051425814628601,
0.0321245901286602,
0.04988956078886986,
-0.20926302671432495,
0.23427526652812958,
0.2547476887702942,
-0.1513955444097519,
-0.41850531101226807,
0.35146018862724304,
-0.004317816346883774,
-0.02116689272224903,
-0.24518360197544098,
-0.20469172298908234,
0.06622713804244995,
0.2883828282356262,
0.2124442756175995,
-0.03962625190615654,
0.3162950873374939,
-0.24571844935417175,
0.24394704401493073,
0.3934978246688843,
-0.01635405421257019,
0.6269670724868774,
-0.6074121594429016,
0.014282128773629665,
0.06745979189872742,
0.3937137722969055,
0.4811592400074005,
0.34842658042907715,
-0.02187288925051689,
0.020672818645834923,
-0.13189803063869476,
-0.23379375040531158,
0.28149276971817017,
0.03126392886042595,
-0.34829020500183105,
-0.21767005324363708,
-0.2731301784515381,
0.0486244335770607,
-0.450065940618515,
-0.2783065438270569,
-0.32800787687301636,
-0.8381109237670898,
-0.6243461966514587,
0.21276646852493286,
-0.7458285093307495,
0.15394730865955353,
-0.11809790134429932,
-0.24437710642814636,
-0.3906841576099396,
-0.17563118040561676,
0.10204127430915833,
-0.14437733590602875,
0.10892388224601746,
0.32886263728141785,
-0.19615259766578674,
0.9404881596565247,
-0.18532299995422363,
0.19687975943088531,
-0.06551139056682587,
-0.10702073574066162,
0.14191731810569763,
-0.2513429522514343,
-0.18355457484722137,
0.47684234380722046,
0.42336347699165344,
0.6917991042137146,
-0.15239909291267395,
0.15285585820674896,
-0.004852070938795805,
-0.5182076096534729,
-0.20768775045871735,
0.07434848695993423,
0.21153037250041962,
0.1160535141825676,
-0.40266063809394836,
-0.43863391876220703,
-0.4791446030139923,
-0.07771826535463333,
-0.26423752307891846,
-0.7016051411628723,
-0.18833869695663452,
0.39953482151031494,
0.15100523829460144,
0.29860028624534607,
-0.10317853093147278,
-0.31347909569740295,
-0.5690975189208984,
-0.07969322800636292,
-0.2695675194263458,
0.1806650459766388,
-0.6428775787353516,
-0.34107956290245056,
0.17055681347846985,
-0.14399506151676178,
0.19656024873256683,
0.1419656127691269,
-0.2774176001548767,
-0.012203365564346313,
0.3494594693183899,
-0.12960997223854065,
0.06315760314464569,
0.5218316912651062,
-0.21056333184242249,
0.3564237654209137,
-0.14231976866722107,
-0.4432903528213501,
-0.11138418316841125,
-0.35196453332901,
-0.2974119782447815,
0.0787106454372406,
-0.2937743067741394,
-0.03971744701266289,
-0.04023740813136101,
0.20144477486610413,
-0.4169081151485443,
0.1165824607014656,
-0.2092365175485611,
-0.23020359873771667,
0.2586861252784729,
0.49309173226356506,
0.6554807424545288,
0.20614227652549744,
0.43608054518699646,
0.5094649195671082,
-0.07885617762804031,
-0.1334833949804306,
0.41179290413856506,
-0.3938334584236145,
1.6246775388717651,
-0.28725600242614746,
-0.3877432942390442,
0.6565096974372864,
-0.01903401128947735,
-0.4321957230567932,
-0.5439143180847168,
0.1254419982433319,
0.5481953620910645,
-0.24185949563980103,
-0.6700617671012878,
0.21476449072360992,
0.15993976593017578,
-0.3826233744621277,
-0.043203216046094894,
0.23270605504512787,
0.19591844081878662,
-0.24756605923175812,
0.08168790489435196,
-0.16510719060897827,
0.4883922040462494,
-0.3925783932209015,
0.2178063541650772,
0.05564757063984871,
-0.15185768902301788,
0.16008800268173218,
0.5249240398406982,
-0.7270655035972595,
0.2166603058576584,
0.912223219871521,
-0.3891574442386627,
0.345115065574646,
0.4346145987510681,
0.09930470585823059,
0.30993080139160156,
-0.16183161735534668,
0.5334106087684631,
-0.39521855115890503,
0.4220142066478729,
-0.13976028561592102,
-0.1643722653388977,
0.1278146654367447,
0.037227924913167953,
0.018408184871077538,
-0.05735959857702255,
-0.38833510875701904,
0.26395437121391296,
0.34728190302848816,
-0.2265588492155075,
0.15993842482566833,
0.05913007631897926,
-0.5136226415634155,
0.006062078755348921,
0.5927714109420776,
-0.8193506002426147,
-0.25975489616394043,
0.2046455591917038,
0.22891589999198914,
0.2113824337720871,
-0.1886845827102661,
0.29616180062294006,
-0.10621683299541473,
-0.1010746955871582,
-0.4957614243030548,
-0.007982582785189152,
-0.1634259670972824,
-0.21856820583343506,
-0.08566213399171829,
0.19639809429645538,
-0.09740350395441055,
-0.10241535305976868,
-0.21965405344963074,
-0.8613430261611938,
-0.35642334818840027,
0.929297924041748,
0.45120769739151,
0.937362551689148,
0.31886836886405945,
-0.43153098225593567,
-0.13444842398166656,
0.024474360048770905,
-0.5599523186683655,
0.21263399720191956,
0.7487099766731262,
-0.6230701804161072,
-0.2942798137664795,
-0.1607023924589157,
0.13492752611637115,
0.5719654560089111,
-0.25588667392730713,
-0.3127480745315552,
-0.1576770842075348,
-0.30133360624313354,
-0.5674018263816833,
-0.35537654161453247,
-0.2915782332420349,
-0.12234342098236084,
0.5153407454490662,
-0.4681016802787781,
-0.4262174665927887,
-0.14121097326278687,
0.21209827065467834,
-0.17984728515148163,
0.7377541065216064,
0.630369246006012,
-0.0455351322889328,
-0.26897555589675903,
0.10566067695617676,
-0.30984997749328613,
-0.03272077068686485,
-0.06158947944641113,
-0.1175924614071846,
-0.19058141112327576,
0.3871084153652191,
-6.188693046569824,
-0.11750846356153488,
-0.1407891809940338,
0.5172380208969116,
0.11048240214586258,
0.040812861174345016,
0.9778918623924255,
-0.23507483303546906,
0.14897166192531586,
0.5860826373100281,
0.0024471315555274487,
0.5190672874450684,
0.06125896796584129,
-0.2768333852291107,
-0.05835482105612755,
0.37416237592697144,
0.07614036649465561,
-0.4114571809768677,
0.5779954791069031,
0.10112743079662323,
0.2759897708892822,
0.17954882979393005,
-0.10898647457361221,
0.5365491509437561,
0.09735303372144699,
0.25950926542282104,
-1.0894367694854736,
0.7877724170684814,
-0.34105491638183594,
-0.056108590215444565,
-0.28127676248550415,
-0.49842238426208496,
-0.4557535648345947,
-0.15782861411571503,
0.46596550941467285,
-0.09463819116353989,
-0.20215894281864166,
-0.37524503469467163,
-0.426856130361557,
-0.16071859002113342,
0.04972165450453758,
0.045458413660526276,
-0.26596999168395996,
-0.10350243002176285,
0.13065846264362335,
-0.14358603954315186,
0.01895708031952381,
-0.18674319982528687,
-0.2590266168117523,
0.5122268199920654,
-0.20451365411281586,
0.019914908334612846,
0.12057354301214218,
0.5221086144447327,
0.3638722896575928,
0.1933971345424652,
-0.24840432405471802,
0.1545068621635437,
-0.09572448581457138,
0.20919069647789001,
-0.02996998466551304,
0.06444252282381058,
-0.223117396235466,
-0.24252788722515106,
-0.03763420879840851,
-0.11697299033403397,
-0.37132924795150757,
-0.2215946763753891,
0.16294339299201965,
-0.25962352752685547,
-0.23929736018180847,
0.07517275959253311,
0.1683414876461029,
-0.7003685235977173,
0.5013853311538696,
-0.3676248788833618,
0.20761160552501678,
0.0729793906211853,
-0.017312394455075264,
0.28631719946861267,
-0.5130354166030884,
-0.2397998869419098,
0.2689143121242523,
0.3743075728416443,
0.1261225938796997,
-0.3152313530445099,
-0.22936592996120453,
-0.25267350673675537,
-0.16039203107357025,
0.18626463413238525,
0.42029958963394165,
-0.044884487986564636,
0.2301320731639862,
0.36522650718688965,
0.035301052033901215,
0.15645800530910492,
0.1754971146583557,
0.14351072907447815,
0.4750189483165741,
0.1794978380203247,
0.9991796612739563,
-0.13001492619514465,
-0.18119581043720245,
-0.6055392026901245,
-0.00016377419524360448,
-0.07638966292142868,
0.036490049213171005,
0.03594287857413292,
0.48921191692352295,
-0.4665279984474182,
-0.07028311491012573,
0.26234281063079834,
-0.18161775171756744,
0.08615344017744064,
0.8607262372970581,
-0.2307458519935608,
-0.0492040179669857,
0.09231765568256378,
0.6270010471343994,
0.1388111710548401,
0.2120022177696228,
0.3604271113872528,
-0.7563167214393616,
0.09706059843301773,
-0.19315515458583832,
-0.21886757016181946,
0.19381384551525116,
0.19478702545166016,
-0.3468065857887268,
0.01705021969974041,
0.06106904149055481,
0.07905833423137665,
-0.34659504890441895,
-0.4310462474822998,
0.4177798628807068,
-0.1069817841053009,
-0.6422966718673706,
0.19483603537082672,
0.16705010831356049,
-0.2688332200050354,
-0.03098965808749199,
-0.27044108510017395,
-0.13618475198745728,
0.4059178829193115,
-0.04988076165318489,
-0.00012130514369346201,
0.3287160396575928,
-0.16518115997314453,
-0.20162487030029297,
0.04395528510212898,
0.42695361375808716,
-0.15098437666893005,
0.24698488414287567,
0.22767476737499237,
-0.34347599744796753,
-0.017594190314412117,
0.507015585899353,
0.6692796349525452,
0.22149775922298431,
-0.4985717236995697,
0.33829039335250854,
0.27591389417648315,
-0.846784234046936,
0.0753856971859932,
0.009763971902430058,
-0.7917034029960632,
-0.19378820061683655,
-0.14292460680007935,
0.1632312834262848,
0.3699926733970642,
-0.1885857880115509,
-0.4606095552444458,
0.0016417679144069552,
0.007412705570459366,
-0.19097654521465302,
0.1444174349308014,
-0.2910698354244232,
-0.328961044549942,
-0.19626867771148682,
-0.07961729913949966,
0.09921073913574219,
-0.3149785101413727,
-0.38477417826652527,
0.32398173213005066,
0.3442718982696533,
0.24109786748886108,
-0.030432218685746193,
-0.4896925985813141,
0.005872537847608328,
-0.09561432898044586,
0.3581221401691437,
-0.004475788678973913,
0.3913956582546234,
0.06598296016454697,
-0.23686394095420837,
-0.013570554554462433,
-0.04435143247246742,
0.34948933124542236,
0.014148448593914509,
-0.4047607183456421,
0.04430728778243065,
0.4830680191516876,
-0.3347991406917572,
0.03499078005552292,
0.3618227243423462,
-0.1867765635251999,
-0.33899614214897156,
0.22954832017421722,
0.14689777791500092,
-0.17218908667564392,
-0.0912291407585144,
-0.5066802501678467,
0.16201770305633545,
0.01835949905216694,
-0.29718297719955444,
0.414943128824234,
0.23957596719264984,
-0.49344146251678467,
-0.15521784126758575,
-0.15498480200767517,
0.13627201318740845,
-0.15149927139282227,
0.16427777707576752,
-0.2604171335697174,
-0.41879233717918396,
-0.09157165139913559,
0.5314178466796875,
-0.3957306146621704,
0.13931627571582794,
0.3942227363586426,
0.03588268905878067,
-0.05676470696926117,
0.20062558352947235,
0.2642202377319336,
-0.696627676486969,
-0.02243826724588871,
-0.3551096022129059,
-0.022730359807610512,
0.10993222892284393,
0.13403375446796417,
-0.08573983609676361,
0.07710760086774826,
-0.14052481949329376,
0.21461062133312225,
0.008764039725065231,
0.1834479421377182,
0.46090057492256165,
-0.3888143301010132,
-0.05485455319285393,
-0.012198989279568195,
0.44581273198127747,
-0.19762390851974487,
0.10523384064435959,
-0.027310799807310104,
0.8001561164855957,
0.21917732059955597,
0.12467940896749496,
0.0672316923737526,
-0.18963846564292908,
0.2689708173274994,
-0.26436886191368103,
0.4224466383457184,
-0.5120559334754944,
0.004120060242712498,
-0.3882434666156769,
-0.11581647396087646,
-0.5142470002174377,
-0.5312331318855286,
0.3413093388080597,
-0.004830928053706884,
-0.30328476428985596,
0.09590620547533035,
0.538906455039978,
1.1016489267349243,
0.31611233949661255,
0.6822491884231567,
-0.26091623306274414,
-0.0019002854824066162,
-0.362537145614624,
0.13639414310455322,
-0.6989976763725281,
-0.3033605217933655,
0.4546036124229431,
-0.16489726305007935,
0.19378559291362762,
-0.507235050201416,
-0.18915201723575592,
-0.31544893980026245,
-0.26904892921447754,
-0.2734382450580597,
0.23272749781608582,
-0.07719720900058746,
-0.6171656847000122,
-0.7483227849006653,
-0.018187139183282852,
0.18091154098510742,
-0.21312259137630463,
0.36069589853286743,
0.08320559561252594,
-0.1511862576007843,
-0.8752074241638184,
0.6321256160736084,
0.9411853551864624,
-0.543222188949585,
-0.2083982527256012,
0.20958834886550903,
0.5639737844467163,
-0.0033681655768305063,
-0.38236749172210693,
-0.15595608949661255,
0.29898151755332947,
0.046080332249403,
-0.4003596305847168,
0.1450924426317215,
-0.27711179852485657,
0.1590491533279419,
-0.11527473479509354,
-0.13658200204372406,
0.2379521131515503,
0.44488462805747986,
0.8157830238342285,
0.691663920879364,
0.3016984462738037,
-0.23841209709644318,
-0.6240141987800598,
0.638893187046051,
0.253835529088974,
0.33805933594703674,
-0.0904344767332077,
0.6292041540145874,
0.29988372325897217,
0.2711428701877594,
-0.3825782239437103,
0.23093539476394653,
0.314802348613739,
0.23019501566886902,
0.1332193911075592,
-0.04748066887259483,
-0.17570747435092926,
0.2559877038002014,
0.9468050003051758,
-0.08228003978729248,
-0.3906887173652649,
-0.41868969798088074,
-0.11726506054401398,
0.25378623604774475,
-0.1199680045247078,
-0.4140198230743408,
-0.35758283734321594,
0.24282976984977722,
0.1368778496980667,
-0.05658066272735596,
-0.34085509181022644,
0.1490839123725891,
-0.8654532432556152,
0.4062528610229492,
0.2696114182472229,
-0.5683783292770386,
-0.5851729512214661,
0.22514575719833374,
-0.3926085829734802,
0.03037160448729992,
-0.2848489582538605,
0.8132926225662231,
-0.22418443858623505,
0.5705050230026245,
0.19109565019607544,
-0.03235720470547676,
-0.32022973895072937,
-0.2144961655139923,
0.08004064112901688,
-0.45621323585510254,
-0.23957784473896027,
0.004317705053836107,
0.2974942922592163,
-0.2532827854156494,
-0.062176864594221115,
0.04947593808174133,
0.00914707686752081,
0.15400443971157074,
-0.32085952162742615,
-0.05849436670541763,
-0.5423310399055481,
-0.529830276966095,
-0.2649792730808258,
0.02462904341518879,
-0.4339783191680908,
0.0737013965845108,
0.1194920465350151,
0.21916772425174713,
0.22922438383102417,
-0.2037002146244049,
0.06496123224496841,
0.1620771586894989,
0.02387775294482708,
-0.0698823630809784,
-0.05550570785999298,
0.4650973081588745,
-0.16719941794872284,
0.06857860833406448,
-0.051277872174978256,
0.2947049140930176,
-0.1285201460123062,
0.43793559074401855,
-0.437205046415329,
0.05311523750424385,
-0.7606985569000244,
0.4266822338104248,
-0.6102389097213745,
0.036555755883455276,
0.4895375967025757,
-0.005539921578019857,
-0.4225596785545349,
0.006259214133024216,
0.21179921925067902,
0.09896798431873322,
0.3637349307537079,
-0.8620611429214478,
-0.15544629096984863,
-0.05393673852086067,
-0.06221584975719452,
-0.5282739400863647,
0.2129012644290924,
0.2061973363161087,
-0.6912201642990112,
-0.14470545947551727,
0.17708663642406464,
0.11563055962324142,
-0.17865541577339172,
0.6202570199966431,
-0.20451757311820984,
0.1696358025074005,
-0.40199318528175354,
-0.029474245384335518,
-0.4709479808807373,
-0.04512643441557884,
0.13250966370105743,
0.5232963562011719,
-0.1941414177417755,
0.2600427269935608,
0.15036442875862122,
-0.22465069591999054,
0.22111117839813232,
-0.21589873731136322,
0.21367545425891876,
-0.043850891292095184,
0.11497031152248383,
-0.5886946320533752,
-0.4338202476501465,
0.16161301732063293,
0.1150769367814064,
-0.41415607929229736,
-0.3762732148170471,
0.3545590043067932,
-0.011462817899882793,
-0.22558404505252838,
0.0395553894340992,
-0.35282671451568604,
0.4301793873310089,
-0.026535136625170708
] |
A shortcoming of most correlation distance methods based on the composition vectors without alignment developed for phylogenetic analysis using complete genomes is that the “distances” are not proper distance metrics in the strict mathematical sense. In this paper we propose two new correlation-related distance metrics to replace the old one in our dynamical language approach. Four genome datasets are employed to evaluate the effects of this replacement from a biological point of view. We find that the two proper distance metrics yield trees with the same or similar topologies as/to those using the old “distance” and agree with the tree of life based on 16S rRNA in a majority of the basic branches. Hence the two proper correlation-related distance metrics proposed here improve our dynamical language approach for phylogenetic analysis. | [
0.0010677615646272898,
0.012233308516442776,
-0.020445428788661957,
0.014676341786980629,
-0.0027911991346627474,
-0.00779272336512804,
0.009731767699122429,
-0.010853694751858711,
-0.012042626738548279,
-0.026411063969135284,
0.003127502044662833,
0.010604322887957096,
-0.0013413215056061745,
0.008331111632287502,
-0.0011635026894509792,
0.02024652063846588,
0.0014430375304073095,
0.004385014995932579,
0.003646576777100563,
-0.025022048503160477,
0.00794246420264244,
0.007866330444812775,
0.010289506055414677,
0.012343637645244598,
-0.02945386990904808,
0.013171810656785965,
0.002097337506711483,
0.0004921371582895517,
-0.0033504192251712084,
0.02194144017994404,
-0.012888521887362003,
-0.018840892240405083,
0.019758714362978935,
0.013187294825911522,
0.0026276884600520134,
0.008320122957229614,
-0.0022566094994544983,
0.016261272132396698,
-0.021395716816186905,
-0.004419069737195969,
-0.0031696760561317205,
-0.0016500686760991812,
-0.0022711504716426134,
-0.012817170470952988,
-0.010468641296029091,
0.019222339615225792,
-0.0021523279137909412,
0.0028088411781936884,
-0.0071761771105229855,
0.00958302803337574,
-0.01408430002629757,
0.012468017637729645,
-0.009015219286084175,
0.011083952151238918,
-0.006269702687859535,
-0.0057973298244178295,
0.02071269042789936,
0.01908116787672043,
-0.01867794245481491,
0.016529789194464684,
-0.0033888958860188723,
-0.001694565056823194,
0.021679526194930077,
-0.019989218562841415,
0.0006005770992487669,
-0.06711894273757935,
-0.007807132788002491,
0.0055161151103675365,
0.00879647396504879,
-0.02135644666850567,
-0.011823240667581558,
0.014243250712752342,
-0.020715035498142242,
-0.010336846113204956,
0.012867152690887451,
0.021913286298513412,
-0.008130202069878578,
-0.0031736597884446383,
0.024759134277701378,
0.005210439674556255,
-0.013988561928272247,
-0.008805425837635994,
-0.012560516595840454,
0.024671265855431557,
0.009786269627511501,
0.0005940722767263651,
-0.002593420445919037,
0.011280749924480915,
-0.009981118142604828,
0.021500512957572937,
0.016892198473215103,
-0.03652951866388321,
0.016070552170276642,
-0.0007577324286103249,
-0.0008081845007836819,
0.02838285081088543,
-0.01993795670568943,
0.02284133993089199,
0.013783713802695274,
-0.0018844855949282646,
-0.018529899418354034,
0.00022966484539210796,
0.020783236250281334,
-0.01027527917176485,
-0.02818075753748417,
0.012895605526864529,
-0.002700053621083498,
-0.0012759354431182146,
0.004393443465232849,
0.0035690627992153168,
0.010140234604477882,
0.00934712216258049,
-0.002594579244032502,
0.001724079716950655,
0.01671052910387516,
0.0064549678936600685,
0.007413282059133053,
-0.032997213304042816,
0.0031305551528930664,
-0.023949455469846725,
0.02780872955918312,
0.0029895445331931114,
0.0018997914157807827,
-0.013235598802566528,
0.0034307700116187334,
0.0191352516412735,
-0.018541496247053146,
-0.0042216419242322445,
0.0070814997889101505,
0.007779371924698353,
-0.011167972348630428,
0.009644836187362671,
0.0020760176703333855,
0.005013392772525549,
0.01207113265991211,
-0.002558768028393388,
-0.006952257826924324,
0.017987048253417015,
0.004037031903862953,
-0.01006549783051014,
-0.008018291555345058,
0.012310763821005821,
-0.0016212210757657886,
0.005439187400043011,
-0.010664686560630798,
0.005511044058948755,
0.0177500881254673,
0.002615259727463126,
-0.01596180349588394,
-0.00285544921644032,
-0.0052134376019239426,
-0.014671163633465767,
-0.01696821302175522,
-0.010779649950563908,
0.024524450302124023,
-0.01094844937324524,
-0.007165069691836834,
-0.002478310838341713,
-0.005882120691239834,
0.015047499909996986,
-0.003245372325181961,
-0.009234944358468056,
0.004229923710227013,
0.009067492559552193,
0.024745415896177292,
0.02293465845286846,
-0.0033454489894211292,
0.012457611039280891,
-0.010429415851831436,
0.002205871045589447,
-0.012128092348575592,
-0.011482106521725655,
-0.00649347435683012,
0.007852625101804733,
0.006665331311523914,
0.0023970017209649086,
0.004848939832299948,
0.005514574237167835,
-0.012410393916070461,
0.06697604060173035,
0.004882532637566328,
-0.006090062204748392,
0.002845748793333769,
0.015441573224961758,
-0.007934685796499252,
-0.008230287581682205,
-0.003051806939765811,
0.0010515961330384016,
0.004842306021600962,
-0.0031778409611433744,
-0.03027886338531971,
0.0007063729572109878,
0.021384544670581818,
0.016634443774819374,
-0.009588783606886864,
0.00271997950039804,
-0.0035079428926110268,
-0.0029252097010612488,
-0.0019620349630713463,
0.0016312194056808949,
-0.015509714372456074,
0.002011357108131051,
0.00311587518081069,
0.020544741302728653,
0.006384612061083317,
0.015040738508105278,
0.003934558946639299,
0.01726268045604229,
0.01064014807343483,
0.008687980473041534,
0.0078038438223302364,
-0.011613672599196434,
-0.010477907955646515,
-0.015003151260316372,
0.00255434587597847,
0.007291343528777361,
-0.008734000846743584,
-0.01852111704647541,
0.0013569565489888191,
-0.01608041487634182,
0.00761617673560977,
0.00101831229403615,
0.00671722274273634,
0.004381746053695679,
0.020353270694613457,
-0.01771857589483261,
-0.008033308200538158,
0.011253155767917633,
0.010623747482895851,
0.0010542983654886484,
0.009253275580704212,
-0.013186104595661163,
-0.011661716736853123,
0.0029550744220614433,
-0.0023392161820083857,
0.01506635919213295,
0.01138330064713955,
-0.009425902739167213,
-0.00314239040017128,
-0.008558986708521843,
-0.01411793939769268,
0.007395569700747728,
0.011324780061841011,
-0.006295203231275082,
0.0007076007314026356,
-0.009381881915032864,
-0.020173272117972374,
0.00469445763155818,
0.01964578405022621,
-0.013319048099219799,
0.0005175264668650925,
-0.0026593797374516726,
0.024903925135731697,
-0.0010783271864056587,
0.0007386939832940698,
-0.004087531007826328,
-0.01103946939110756,
0.012467864900827408,
0.024609971791505814,
-0.011493552476167679,
-0.00818482507020235,
0.0020444730762392282,
-0.00880155898630619,
0.016295624896883965,
-0.01748812198638916,
0.008270063437521458,
0.006309740711003542,
0.02660217322409153,
0.018546568229794502,
0.005984508898109198,
0.00218394142575562,
-0.012601489201188087,
-0.0020151659846305847,
-0.08145557343959808,
-0.008388344198465347,
0.008611858822405338,
-0.008812122978270054,
0.008228113874793053,
0.00114075792953372,
0.008292660117149353,
0.0020152574870735407,
-0.018841072916984558,
-0.017683176323771477,
0.02034861035645008,
0.0037020777817815542,
-0.012195371091365814,
-0.009391676634550095,
0.0019432834815233946,
-0.012088455259799957,
0.007341763935983181,
-0.0008100692648440599,
0.0014441402163356543,
-0.024637771770358086,
-0.029249142855405807,
-0.023166058585047722,
0.0011162180453538895,
-0.000683668302372098,
0.02492641843855381,
-0.004871675744652748,
0.025144143030047417,
-0.0046434300020337105,
-0.010910709388554096,
-0.0011467277072370052,
0.0034205943811684847,
-0.01622260920703411,
0.033688828349113464,
-0.015935620293021202,
0.020462732762098312,
-0.003092119935899973,
0.009424805641174316,
0.01997534930706024,
-0.0013342174934223294,
0.01913825049996376,
0.016784897074103355,
0.004636174999177456,
-0.0002473865752108395,
0.007167183794081211,
0.0030799503438174725,
0.008403954096138477,
0.010778623633086681,
0.018500111997127533,
0.014083083719015121,
0.007530679926276207,
0.031603891402482986,
-0.0041303569450974464,
0.015472606755793095,
0.012035907246172428,
-0.0093604177236557,
0.007107594981789589,
0.004942417144775391,
0.012333095073699951,
-0.008010181598365307,
-0.004985584877431393,
-0.007426705211400986,
-0.023784149438142776,
-0.012548747472465038,
-0.003652864834293723,
0.0026507051661610603,
-0.03582408279180527,
0.010714447125792503,
-0.008671047165989876,
0.003028961131349206,
-0.018790658563375473,
0.005403556860983372,
-0.025243496522307396,
-0.002660513622686267,
0.0007931919535622001,
-0.004915587138384581,
-0.014721803367137909,
-0.011912507936358452,
-0.011166632175445557,
0.009153241291642189,
0.007282913662493229,
-0.01889946684241295,
0.01464618369936943,
-0.007331665605306625,
-0.010099412873387337,
-0.03201824426651001,
0.004217642825096846,
-0.0005275857402011752,
-0.019103314727544785,
0.011894432827830315,
-0.012429920956492424,
0.024403054267168045,
0.0025503868237137794,
-0.010610184632241726,
0.007953736931085587,
-0.005597294773906469,
-0.005351599771529436,
0.01470150239765644,
0.010073760524392128,
0.012498372234404087,
0.010456549003720284,
-0.011168006807565689,
0.00758757209405303,
-0.0018611731939017773,
-0.014459703117609024,
-0.0013616601936519146,
0.008767240680754185,
-0.0018607997335493565,
-0.005287857260555029,
0.0182250514626503,
-0.007394318003207445,
-0.021332738921046257,
-0.03469841182231903,
-0.007649247534573078,
0.01377587765455246,
0.01419608574360609,
0.011812815442681313,
-0.012064198032021523,
0.019873568788170815,
0.07243591547012329,
0.02186889387667179,
0.013221461325883865,
0.0063052307814359665,
-0.02060120180249214,
-0.01440622378140688,
-0.021298643201589584,
-0.0011112161446362734,
-0.020043689757585526,
-0.003140079788863659,
0.012141222134232521,
0.022037411108613014,
-0.012920686975121498,
0.026933645829558372,
-0.019823607057332993,
-0.0011192812817171216,
0.023037321865558624,
0.016345594078302383,
-0.00390802975744009,
-0.009266743436455727,
0.007496628910303116,
-0.024528492242097855,
-0.01986881159245968,
-0.008690228685736656,
-0.011819956824183464,
-0.03795873373746872,
0.022564787417650223,
-0.017481589689850807,
-0.0001876968890428543,
-0.00013266521273180842,
0.014528109692037106,
0.02027840167284012,
-0.0021519679576158524,
-0.002861368702724576,
0.014926999807357788,
0.044252559542655945,
0.03512843698263168,
-0.008242686279118061,
-0.0035129436291754246,
0.010935920290648937,
0.017744462937116623,
-0.011232025921344757,
0.020416080951690674,
0.015176264569163322,
0.034465763717889786,
0.0031813648529350758,
0.010405387729406357,
-0.0059520043432712555,
0.0018349702004343271,
0.015360028482973576,
-0.0021208026446402073,
0.01221952773630619,
0.010751578956842422,
0.016430161893367767,
-0.0002949843183159828,
-0.01561728771775961,
0.008431865833699703,
-0.011076832190155983,
0.003491087118163705,
-0.008011755533516407,
-0.019789962098002434,
-0.01644274778664112,
0.020492548123002052,
-0.005993613973259926,
0.004275417421013117,
-0.0059093087911605835,
0.006577900145202875,
-0.012292704544961452,
0.007151963654905558,
0.010717922821640968,
-0.003027167869731784,
-0.004499625414609909,
0.007169123273342848,
-0.005609588697552681,
-0.0020829096902161837,
-0.013045843690633774,
0.008133318275213242,
0.014997913502156734,
-0.03691033273935318,
-0.024526894092559814,
-0.014525866135954857,
0.013495002873241901,
-0.011493038386106491,
0.011855591088533401,
0.00793558917939663,
-0.01735675521194935,
0.005800326820462942,
-0.07533703744411469,
-0.004132534377276897,
0.01403280720114708,
-0.005515477620065212,
0.0032472205348312855,
0.02449467033147812,
-0.009806089103221893,
-0.013857914134860039,
0.02264084294438362,
-0.0021704176906496286,
-0.004273565486073494,
-0.011278458870947361,
-0.018223240971565247,
-0.010626202449202538,
0.011995388194918633,
0.03315567225217819,
-0.019530080258846283,
0.005889657884836197,
0.014476493000984192,
0.012211933732032776,
-0.002215885091573,
0.01552334800362587,
0.011076693423092365,
-0.011558238416910172,
-0.016874438151717186,
-0.08156883716583252,
-0.027736695483326912,
0.004793387837707996,
0.004579475149512291,
-0.016687018796801567,
-0.01313168928027153,
0.026476310566067696,
-0.016777794808149338,
0.005093153566122055,
-0.014258496463298798,
-0.019543573260307312,
-0.008153981529176235,
-0.01978442072868347,
0.006886709481477737,
0.00009892880916595459,
0.004082634579390287,
0.015609851107001305,
-0.02082742564380169,
-0.004978992976248264,
-0.013865881599485874,
-0.001392734469845891,
-0.0018948116339743137,
-0.00817939080297947,
-0.006992778740823269,
-0.00797764677554369,
-0.020409181714057922,
-0.0048445723950862885,
0.015181779861450195,
-0.002468931023031473,
0.014391609467566013,
0.02535611018538475,
-0.013517475686967373,
0.004439651500433683,
-0.01979687809944153,
0.0034951725974678993,
-0.010317971929907799,
-0.019735265523195267,
-0.022242428734898567,
-0.011184051632881165,
0.0006264876574277878,
0.0006629219278693199,
0.02439514920115471,
-0.007632103748619556,
0.01248821523040533,
-0.005272886715829372,
-0.013450650498270988,
0.002662675455212593,
-0.011062175035476685,
0.001875055953860283,
0.011864752508699894,
0.006401098798960447,
-0.013081167824566364,
0.015419208444654942,
0.003132252022624016,
0.01399447862058878,
0.011667427606880665,
-0.005245057400316,
0.002942575141787529,
0.014696948230266571,
0.01214221678674221,
0.007132310885936022,
0.01859535276889801,
0.008400296792387962,
0.07188498973846436,
-0.025913897901773453,
0.0009306076681241393,
-0.005977152846753597,
-0.019206171855330467,
-0.004158463794738054,
-0.025413697585463524,
0.0007144906558096409,
-0.0013692674692720175,
-0.01047663576900959,
-0.006433530710637569,
0.011358989402651787,
-0.008874358609318733,
0.008071357384324074,
-0.006331784650683403,
0.010635172948241234,
0.00028398726135492325,
0.026354413479566574,
0.02156640961766243,
-0.028031563386321068,
0.017408156767487526,
0.023701969534158707,
-0.02246595174074173,
0.0138784758746624,
0.012776662595570087,
-0.011042403988540173,
-0.004412510897964239,
-0.012816308066248894,
0.013298231177031994,
0.008883800357580185,
-0.012378654442727566,
0.003205647226423025,
0.004819320514798164,
-0.0048223636113107204,
0.02161438763141632,
0.0015779284294694662,
0.01699869893491268,
0.0006639109342359006,
-0.001411880599334836,
-0.0007061618380248547,
-0.009111519902944565,
-0.009780926629900932,
0.0003837008262053132,
-0.010119006037712097,
0.006406865082681179,
0.01367630809545517,
-0.001590934582054615,
0.03117237612605095,
-0.00037214788608253,
0.004092208109796047,
0.010420416481792927,
0.00044154352508485317,
0.0004756352864205837,
0.005804507993161678,
0.015227947384119034,
0.024684550240635872,
-0.025896446779370308,
0.02451585792005062,
0.0066525572910904884,
0.009912076406180859,
-0.012747639790177345,
-0.010490711778402328,
-0.016535405069589615,
-0.003599718678742647,
0.007114918902516365,
-0.0014743930660188198,
-0.0075947437435388565,
-0.017637761309742928,
0.0036898464895784855,
0.01726198010146618,
-0.012904727831482887,
0.004202408250421286,
0.0010176802752539515,
0.001122860237956047,
0.0196516215801239,
-0.025786587968468666,
-0.02588426135480404,
0.009617934003472328,
0.014442985877394676,
-0.00350576383061707,
-0.007687276229262352,
0.02391577884554863,
0.023388294503092766,
-0.015244056470692158,
-0.0002976565156131983,
0.022693004459142685,
0.015231781639158726,
0.004969756118953228,
-0.003991648089140654,
0.009153125807642937,
-0.0013227020390331745,
0.001538397977128625,
-0.004151682369410992,
0.008305145427584648,
0.0022600770462304354,
0.034485943615436554,
-0.0071007017977535725,
0.0017495264764875174,
-0.00029174843803048134,
0.004301508888602257,
0.031064391136169434,
0.008734140545129776,
-0.015443667769432068,
0.022255972027778625,
-0.032071955502033234,
-0.011492418125271797,
0.01117493025958538,
-0.011614959686994553,
0.009683837182819843,
0.0020411675795912743,
-0.016858261078596115,
-0.009182657115161419,
-0.008876784704625607,
-0.02866271324455738,
0.008150266483426094,
-0.019818522036075592,
-0.020371127873659134,
-0.012870440259575844,
-0.00859740562736988,
-0.007094425614923239,
-0.0014104531146585941,
0.011013006791472435,
0.0038011602591723204,
0.029399331659078598,
0.02608700841665268,
-0.02324657142162323,
-0.011358837597072124,
0.02531515806913376,
-0.0028844638727605343,
-0.020130353048443794,
-0.0014761507045477629,
-0.0012457191478461027,
0.004448124673217535,
0.015572626143693924,
0.01324128732085228,
-0.04668545350432396,
0.0011055886279791594,
0.008490476757287979,
0.0033982994500547647,
0.002724121557548642,
0.018536822870373726,
-0.008464399725198746,
-0.0040281349793076515,
-0.007722476497292519,
0.00861103180795908,
0.008487006649374962,
0.004014137201011181,
0.025091202929615974,
0.004108255263417959,
0.011117209680378437,
-0.0012713706819340587,
0.017749829217791557,
-0.0007612905465066433,
0.000912075920496136,
-0.005470981355756521,
0.01301468163728714,
0.0028047729283571243,
-0.002752613741904497,
0.002711703535169363,
0.0025736899115145206,
-0.0006471900269389153,
0.028049033135175705,
-0.0276093240827322,
0.008447060361504555,
-0.013210911303758621,
-0.007151843048632145,
-0.009173222817480564,
0.011028614826500416,
-0.019777771085500717,
-0.011552263051271439,
0.007690095342695713,
-0.017080603167414665,
-0.0094206053763628,
0.007775240112096071,
-0.0386732779443264,
-0.005434527061879635,
-0.006487143691629171,
0.006940873339772224,
-0.013114730827510357,
0.000625986373052001,
0.010451377369463444,
-0.011783737689256668,
0.00041696999687701464,
-0.010802485048770905,
-0.005112128332257271,
-0.009968292899429798,
-0.00288939755409956,
0.019376134499907494,
0.014570520259439945,
-0.006145154125988483,
0.009425031952559948,
-0.01533154584467411,
-0.020757831633090973,
0.006269735749810934,
-0.006788497790694237,
-0.00781652145087719,
-0.009076395072042942,
-0.01840197667479515,
0.01877199485898018,
0.012185783125460148,
-0.013387848623096943,
0.003023675177246332
] | [
0.18175865709781647,
0.0010390026727691293,
0.05352221429347992,
0.325364887714386,
-0.14547215402126312,
-0.015786541625857353,
0.20670801401138306,
-0.3119029998779297,
-0.17080596089363098,
-0.6269524693489075,
0.548285722732544,
0.21074886620044708,
-0.5589116215705872,
0.39490997791290283,
-0.22181487083435059,
0.4048275351524353,
0.2532234787940979,
0.5915716886520386,
-0.37488898634910583,
-0.6827511191368103,
-0.2177584171295166,
-0.011675196699798107,
0.4487459659576416,
-0.055713966488838196,
-0.18918615579605103,
-0.01591438800096512,
0.4352002441883087,
0.4857478439807892,
0.02307846024632454,
-0.32701703906059265,
0.06507580727338791,
0.6475837230682373,
-0.06654071062803268,
-0.291474848985672,
0.15990404784679413,
-0.4411592483520508,
0.016918467357754707,
0.14426679909229279,
0.5598168969154358,
-0.2931717336177826,
0.11700426042079926,
0.0568479523062706,
-0.38359084725379944,
0.7119315266609192,
-0.37507569789886475,
-0.5041162967681885,
-1.6074861288070679,
0.31283411383628845,
-0.2395118772983551,
-0.1925048679113388,
-0.3539363443851471,
0.07275993376970291,
0.3743487596511841,
0.25175997614860535,
-0.31989189982414246,
0.4042404890060425,
-0.191648930311203,
-0.23074795305728912,
0.45249781012535095,
-0.10673652589321136,
0.05574174225330353,
-0.5621597766876221,
-0.37676283717155457,
0.3143117427825928,
-0.18506668508052826,
0.34129759669303894,
0.330017626285553,
-0.38611480593681335,
-0.7221171259880066,
0.022947166115045547,
0.2776866555213928,
-0.27338892221450806,
-0.18511317670345306,
0.5744286775588989,
-0.14052923023700714,
0.160159170627594,
-0.18770496547222137,
-0.2240688055753708,
0.7904833555221558,
-0.3285812437534332,
-0.0599619597196579,
-0.2668718695640564,
-0.20753850042819977,
-0.3172878921031952,
0.35151243209838867,
0.6374639272689819,
0.005791477393358946,
0.25251951813697815,
-0.7231479287147522,
0.1285247504711151,
-0.35961252450942993,
-0.2521286606788635,
0.10887579619884491,
0.6496894359588623,
0.5887115001678467,
0.40681907534599304,
0.22972197830677032,
-0.04644082486629486,
0.26816028356552124,
0.6294776201248169,
-0.14192639291286469,
-0.21984386444091797,
0.2333756387233734,
-0.4257744550704956,
-0.4131089150905609,
-0.6881678700447083,
-0.5966923832893372,
-0.445277601480484,
-0.30307117104530334,
-0.029480407014489174,
-0.6255942583084106,
0.7173606157302856,
0.044209208339452744,
0.0506909042596817,
-0.18900027871131897,
-0.05707261338829994,
0.10694211721420288,
-0.3316114544868469,
-0.04218732938170433,
0.5038625597953796,
-0.7978646755218506,
1.5451257228851318,
0.06284282356500626,
0.08836773037910461,
0.059539709240198135,
0.40374577045440674,
0.13210387527942657,
0.30606091022491455,
-0.47123026847839355,
0.11967113614082336,
0.1580270677804947,
0.9492571949958801,
-0.05156045779585838,
-0.27102145552635193,
-0.039147473871707916,
-0.8616935610771179,
0.1032542809844017,
0.3757103681564331,
0.015513493679463863,
-0.332913875579834,
-0.2729186713695526,
-0.8747102618217468,
0.20250318944454193,
0.09733877331018448,
0.4926387667655945,
-0.05016172304749489,
-0.3877429962158203,
-0.326261967420578,
-0.018848411738872528,
0.16539369523525238,
0.24787050485610962,
0.24794644117355347,
-1.0094088315963745,
-0.2648915946483612,
-0.21382902562618256,
0.9097214341163635,
-0.15460948646068573,
-0.3350607752799988,
-0.10126141458749771,
0.5095711350440979,
0.15882162749767303,
0.04885938763618469,
-0.629901111125946,
-0.4700934886932373,
0.013065973296761513,
-0.7049134373664856,
0.42821425199508667,
0.7170141935348511,
0.05905682593584061,
-0.15825730562210083,
-0.10372459888458252,
-0.41235488653182983,
-0.40066224336624146,
-0.7905510067939758,
-0.1779523640871048,
0.030586322769522667,
0.04140537604689598,
-0.06843134015798569,
0.008799608796834946,
-0.007050266023725271,
-0.49858683347702026,
0.44497182965278625,
0.2828080952167511,
-0.3154647946357727,
0.13705691695213318,
0.14543642103672028,
0.600727915763855,
-0.10219322890043259,
0.11128557473421097,
-0.20563459396362305,
-0.27993157505989075,
-0.4786863625049591,
0.01651078462600708,
-0.9282616376876831,
1.4750622510910034,
-0.03970300033688545,
-0.21837826073169708,
1.2520198822021484,
-0.12008848041296005,
-0.08511589467525482,
-0.2828146517276764,
0.2307703047990799,
0.14652472734451294,
-0.06385345757007599,
-0.4856562614440918,
0.4406106770038605,
0.19146248698234558,
-0.3130932152271271,
-0.397286057472229,
0.0968661904335022,
0.5547449588775635,
0.04789866879582405,
-0.07760126888751984,
-0.18645180761814117,
0.07713952660560608,
-0.02283291146159172,
-0.09876507520675659,
0.0234009250998497,
-0.03805958852171898,
0.06534401327371597,
0.6228895783424377,
-0.44383490085601807,
0.5817940831184387,
0.482608824968338,
0.09821264445781708,
0.47228410840034485,
0.6954416632652283,
0.388144850730896,
0.740755021572113,
-0.5283432006835938,
0.18168243765830994,
-0.008543015457689762,
0.5302529335021973,
-0.2693946957588196,
-0.21302145719528198,
-0.19368214905261993,
0.2796657085418701,
-0.07172717154026031,
0.07588077336549759,
0.17441171407699585,
-0.08076625317335129,
0.3799408972263336,
-0.3032975196838379,
-0.060995496809482574,
-0.16827841103076935,
-0.628048837184906,
-0.5294300317764282,
-0.029697585850954056,
-0.7168416380882263,
-0.12823009490966797,
0.21194016933441162,
0.4412896931171417,
0.7026691436767578,
-0.6768925189971924,
0.18287809193134308,
0.18008586764335632,
-0.06943917274475098,
-0.6684944033622742,
-0.19569608569145203,
0.12033433467149734,
0.06392420083284378,
0.1515526920557022,
-0.08817553520202637,
-0.20412270724773407,
-0.11199741810560226,
-0.36831483244895935,
-0.9916104674339294,
-1.0617520809173584,
0.733267068862915,
0.5247715711593628,
0.4508322775363922,
-0.09899938106536865,
-0.5471827387809753,
-0.0632362887263298,
-0.20402783155441284,
-0.6989291906356812,
0.31459563970565796,
0.31521090865135193,
-0.9941785931587219,
-0.49160951375961304,
0.03449093550443649,
0.47614338994026184,
0.2891513407230377,
-0.15791597962379456,
-0.706536054611206,
-0.10239145159721375,
0.31950289011001587,
-0.08471385389566422,
-0.10135619342327118,
-0.2593165934085846,
-0.01674618385732174,
0.49113941192626953,
0.07647141814231873,
-0.6599317789077759,
0.3160184919834137,
0.7323645353317261,
0.18867728114128113,
-0.2738441228866577,
0.43891000747680664,
-0.23787765204906464,
-0.48591145873069763,
0.1804967075586319,
0.14625754952430725,
-0.3436449468135834,
-0.38336148858070374,
0.20923662185668945,
-0.3397584855556488,
0.5611591339111328,
-5.954392910003662,
0.03785102814435959,
-0.6896934509277344,
0.04500740393996239,
-0.39501380920410156,
-0.34922486543655396,
0.8797075152397156,
-0.4936300814151764,
0.1741342842578888,
-0.20249119400978088,
0.36294230818748474,
0.1937502771615982,
0.1660987287759781,
0.27902281284332275,
0.3960203230381012,
-0.2710765302181244,
0.5946622490882874,
-0.06335125863552094,
0.7820683717727661,
0.44254299998283386,
-0.10719413310289383,
0.059926316142082214,
0.04996052384376526,
0.05222156643867493,
0.38320863246917725,
-0.15501578152179718,
-0.5527005195617676,
0.07149038463830948,
-0.13495875895023346,
-0.062326349318027496,
-0.025298265740275383,
-0.14719630777835846,
-0.22870014607906342,
-0.25432369112968445,
0.11517836898565292,
0.2545924186706543,
-0.20064973831176758,
0.3826010525226593,
0.3223753869533539,
0.2303670048713684,
0.5994576215744019,
0.2295421063899994,
0.14226874709129333,
-0.0727388858795166,
-0.030871126800775528,
0.06845627725124359,
-0.05678156763315201,
0.10196248441934586,
-0.001819997327402234,
1.1321600675582886,
-0.24199362099170685,
-0.06872940808534622,
0.9330136179924011,
0.09105060994625092,
-0.10162695497274399,
-0.5119854807853699,
0.6578946113586426,
0.023481635376811028,
-0.35551729798316956,
-0.12567000091075897,
0.5230545997619629,
-0.4142449200153351,
0.3958410322666168,
-0.808660089969635,
-0.5488977432250977,
0.13192638754844666,
-0.4550924301147461,
-0.565049409866333,
0.04572468623518944,
-0.07502469420433044,
-0.6101676225662231,
-0.17574161291122437,
0.10871875286102295,
-0.3363606929779053,
0.13737642765045166,
-0.5071680545806885,
-0.23559154570102692,
0.09060743451118469,
-0.24201630055904388,
0.14996767044067383,
-0.20272967219352722,
-0.5400562286376953,
-0.2570236325263977,
0.3038434386253357,
0.4215681552886963,
-0.4501940906047821,
-0.5963223576545715,
-0.07130301743745804,
-0.056341562420129776,
0.24830518662929535,
0.100337915122509,
-0.5379528999328613,
0.5389826893806458,
0.46739286184310913,
1.0028976202011108,
0.5699200630187988,
0.654733419418335,
0.0263065155595541,
0.393518328666687,
-0.04874015972018242,
0.7682772874832153,
0.3085455298423767,
-0.20663581788539886,
-0.6967887878417969,
0.16005495190620422,
-0.18806470930576324,
-0.3209827244281769,
0.3861613869667053,
0.07191359251737595,
-0.498989075422287,
0.010772457346320152,
-0.17046763002872467,
0.034265924245119095,
-0.08824463188648224,
0.1093069538474083,
-0.13639101386070251,
0.08093990385532379,
-0.0018049038480967283,
0.04993493854999542,
-0.2171727418899536,
-0.140456885099411,
0.30181440711021423,
-0.2788172960281372,
-0.03641296923160553,
0.2372756153345108,
-0.6013255715370178,
0.1754966378211975,
0.6250468492507935,
-0.4783070683479309,
-0.3582039773464203,
0.11244872957468033,
0.4667750298976898,
-0.056792519986629486,
-0.149222731590271,
0.20751629769802094,
-0.4733406901359558,
0.06568419933319092,
0.12497816234827042,
0.1782670021057129,
-0.7393489480018616,
0.41404348611831665,
-0.11298646777868271,
-0.35253217816352844,
0.2535082697868347,
0.12435799837112427,
0.23560594022274017,
-0.23883557319641113,
-0.2604958415031433,
-0.32768329977989197,
0.034218188375234604,
-0.44660454988479614,
-0.39346587657928467,
0.3987163305282593,
-0.1283925324678421,
-0.02683951146900654,
-0.2488681823015213,
0.2841600775718689,
0.2591502070426941,
0.12346502393484116,
-0.7100419402122498,
0.4139673113822937,
-0.1869923174381256,
-0.6883173584938049,
0.1322164684534073,
0.1215844377875328,
-0.03135082498192787,
-0.015443679876625538,
0.14207246899604797,
-0.5111134648323059,
0.42453721165657043,
-0.22563861310482025,
-0.30501383543014526,
-0.21922288835048676,
-0.2257726490497589,
-0.006129885092377663,
0.2724986672401428,
0.2357417345046997,
0.14936375617980957,
0.1954917460680008,
-0.16835808753967285,
-0.02277563512325287,
-0.3946540951728821,
-0.14010761678218842,
0.3833272457122803,
0.6276190280914307,
0.48625656962394714,
-0.09906219691038132,
0.07566831260919571,
-0.7035945057868958,
-0.2373412549495697,
0.2840234637260437,
0.09070447087287903,
0.7618435025215149,
-0.25323787331581116,
0.11099198460578918,
-0.08346240222454071,
0.3330530524253845,
-0.16791585087776184,
0.1286880075931549,
-0.46586382389068604,
0.09801555424928665,
0.5357779264450073,
-0.3413671851158142,
0.43399137258529663,
0.3571970462799072,
-0.2665437161922455,
-0.3692755103111267,
0.3191373944282532,
-0.26854607462882996,
-0.3699699938297272,
-0.35817891359329224,
-0.6709129810333252,
-0.22368140518665314,
-0.04974925518035889,
0.20984472334384918,
-0.17562367022037506,
0.5891819596290588,
0.2555052936077118,
-0.15020950138568878,
0.0819721594452858,
0.26496171951293945,
-0.3967157304286957,
-0.293326199054718,
-0.16362856328487396,
-0.17143146693706512,
-0.0802149847149849,
0.4166963994503021,
-0.401012122631073,
-0.09920693933963776,
0.018900802358984947,
0.11563346534967422,
-0.39126697182655334,
0.14905494451522827,
-0.03883272036910057,
-0.4301377832889557,
-0.30478107929229736,
-0.5783774852752686,
0.5928428173065186,
-0.3634231388568878,
-0.2719133794307709,
-0.03918412700295448,
1.1032414436340332,
-0.17360658943653107,
-0.21971194446086884,
-0.324891597032547,
0.2395716905593872,
0.08641843497753143,
-0.5286838412284851,
-0.6189075112342834,
-0.20080271363258362,
0.0366046205163002,
0.035109225660562515,
0.12279649078845978,
0.5110889673233032,
0.5758918523788452,
0.5135210156440735,
-0.3328678607940674,
-0.5491110682487488,
0.2799045741558075,
0.33165207505226135,
-0.1608678698539734,
-0.47861069440841675,
-0.3203478753566742,
-0.26056042313575745,
0.1006716638803482,
0.18903085589408875,
-0.08673146367073059,
-0.6836420893669128,
0.3475579619407654,
-0.0038821669295430183,
-0.08138196170330048,
0.1286134123802185,
-0.006563110277056694,
0.599449634552002,
-0.09891251474618912,
0.16166755557060242,
-0.4025084972381592,
0.6133400797843933,
-0.06757792830467224,
-0.1739133596420288,
-0.021694207563996315,
-0.48825007677078247,
-0.07241349667310715,
-0.16790837049484253,
-0.18753713369369507,
0.26063424348831177,
0.3956754505634308,
0.1047637090086937,
0.48636600375175476,
-0.3518272042274475,
-0.6412637829780579,
0.2582622170448303,
-0.5200046896934509,
-0.535300612449646,
0.07860687375068665,
0.17073954641819,
0.4373743534088135,
0.5240264534950256,
0.03090997412800789,
-0.41727548837661743,
-0.07032284140586853,
0.7480998635292053,
0.8898127675056458,
-0.7276449799537659,
0.36891138553619385,
0.34857499599456787,
0.1670810431241989,
0.5136902332305908,
0.2177746444940567,
0.21920724213123322,
0.6833533644676208,
0.46162673830986023,
0.34008219838142395,
0.5364739298820496,
-0.22238264977931976,
0.07941104471683502,
0.4642914831638336,
0.34813937544822693,
0.9092092514038086,
-0.042019590735435486,
0.2588370740413666,
0.2719588577747345,
0.47358188033103943,
-0.3586658239364624,
-0.5925675630569458,
0.587225079536438,
-0.15457607805728912,
0.13531088829040527,
-0.26222333312034607,
0.327300488948822,
0.33588162064552307,
0.4222114086151123,
-0.6335863471031189,
0.28712522983551025,
-0.024212846532464027,
0.12013176828622818,
0.032712746411561966,
-0.2952469289302826,
0.03443553298711777,
0.17422489821910858,
0.7958093881607056,
0.16516095399856567,
-0.28315797448158264,
0.172604039311409,
-0.13891059160232544,
0.23933495581150055,
-0.19166892766952515,
-0.09244756400585175,
-0.15698035061359406,
0.444720596075058,
0.4435250461101532,
0.15856796503067017,
-0.3032495677471161,
-0.12145767360925674,
-0.10134296864271164,
-0.17894338071346283,
0.44281846284866333,
-0.2031005322933197,
-0.07605729252099991,
0.21149148046970367,
-0.16418835520744324,
0.690965473651886,
-0.6914742588996887,
0.021435074508190155,
-0.5059062838554382,
-0.19558775424957275,
0.7323890328407288,
0.6444750428199768,
-0.18098917603492737,
-0.2195562720298767,
-0.297354131937027,
-0.15858928859233856,
-0.4175845682621002,
0.13037608563899994,
-0.03775694593787193,
-0.7445472478866577,
-0.1955178678035736,
0.009519166313111782,
-0.07322472333908081,
0.12368151545524597,
0.0537608377635479,
0.12531037628650665,
-0.12990429997444153,
-0.2219439595937729,
-0.13625481724739075,
-0.11755497753620148,
0.26573944091796875,
0.24527060985565186,
0.36595991253852844,
0.15994684398174286,
0.6528182029724121,
-0.6430843472480774,
-0.20684914290905,
0.08262460678815842,
-0.013919568620622158,
0.22061654925346375,
-0.5117340683937073,
1.0075812339782715,
0.23113738000392914,
-0.0034325653687119484,
0.0037205186672508717,
0.14650049805641174,
0.06051625311374664,
0.7858420610427856,
-0.37845680117607117,
0.44089800119400024,
-0.29063743352890015,
0.016618050634860992,
-0.485014945268631,
0.04217086359858513,
0.702852725982666,
-0.11588292568922043,
-0.4341759979724884,
-0.3176271319389343,
-0.02504069358110428,
0.2542462646961212,
0.04071659967303276,
-0.2757776081562042,
-0.2550787031650543,
-0.11346487700939178,
-0.0679987370967865,
-0.41752833127975464,
0.6167840957641602,
-0.1588468998670578,
0.08476867526769638,
-0.2487281709909439,
-0.0600966140627861,
0.3547380864620209,
-0.3348809480667114,
0.2490462362766266,
0.2263108342885971,
0.04274820163846016,
-0.15905649960041046,
0.3964400291442871,
-0.30316656827926636,
-0.11334189772605896,
-0.031548500061035156,
0.09671971201896667,
0.4502408802509308,
-0.4524981677532196,
-0.5919200778007507,
-0.2561304271221161,
0.025821592658758163,
0.2002744972705841,
-0.21343748271465302,
0.3024276793003082,
0.09858348220586777,
-0.5407148599624634,
-0.4897483289241791,
0.3000637888908386,
0.06432206183671951,
0.06077050417661667,
-0.37539544701576233,
-0.06426554173231125,
-0.36619532108306885,
-0.16682744026184082,
-0.3664042055606842,
-0.5180212259292603,
0.39831191301345825,
0.056078240275382996
] |
BACKGROUND: The highly pathogenic avian influenza (HPAI) virus H5N1 causes multi-organ disease and death in poultry, resulting in significant economic losses in the poultry industry. In addition, it poses a major public health threat as it can be transmitted directly from infected poultry to humans with very high (60%) mortality rate. Effective vaccination against HPAI H5N1 would protect commercial poultry and would thus provide an important control measure by reducing the likelihood of bird-to-bird and bird-to-human transmission. METHODOLOGY/PRINCIPAL FINDINGS: In the present study we evaluated the vaccine potential of recombinant soluble trimeric subtype 5 hemagglutinin (sH5(3)) produced in mammalian cells. The secreted, purified sH5(3) was biologically active as demonstrated by its binding to ligands in a sialic acid-dependent manner. It was shown to protect chickens, in a dose-dependent manner, against a lethal challenge with H5N1 after a single vaccination. Protected animals did not shed challenge virus as determined by a quantitative RT-PCR on RNA isolated from trachea and cloaca swabs. Also in mice, vaccination with sH5(3) provided complete protection against challenge with HPAI H5N1. CONCLUSIONS/SIGNIFICANCE: Our results demonstrate that sH5(3) constitutes an attractive vaccine antigen for protection of chickens and mammals against HPAI H5N1. As these recombinant soluble hemagglutinin preparations can be produced with high yields and with relatively short lead time, they enable a rapid response to circulating and potentially pandemic influenza viruses. | [
-0.017433717846870422,
0.013565551489591599,
-0.004610836505889893,
0.024835677817463875,
0.027175426483154297,
-0.023187626153230667,
0.009244692511856556,
0.007890909910202026,
-0.01303786225616932,
-0.030382327735424042,
-0.017453555017709732,
0.01818428933620453,
-0.013232817873358727,
0.01762130856513977,
-0.004404555540531874,
-0.006068510003387928,
-0.010355512611567974,
0.014763891696929932,
0.013350842520594597,
-0.018046433106064796,
0.007468702271580696,
0.01156589575111866,
0.010124719701707363,
-0.025465626269578934,
-0.024762731045484543,
0.0025199726223945618,
-0.006618852727115154,
-0.01652296632528305,
0.015328183770179749,
0.012417757883667946,
0.02198777161538601,
0.0040392144583165646,
0.02319403365254402,
-0.00928751565515995,
0.012331940233707428,
0.03504267334938049,
-0.003931672312319279,
0.0272938571870327,
0.030809231102466583,
-0.004727788269519806,
0.009545672684907913,
-0.012398160994052887,
0.009057843126356602,
-0.0025349678471684456,
-0.00611494854092598,
0.024197455495595932,
0.00009478512220084667,
0.008547923527657986,
0.0193826574832201,
0.004196027759462595,
0.0038541604299098253,
0.012238821014761925,
-0.007768724113702774,
-0.008761541917920113,
-0.006305688060820103,
0.011897924356162548,
0.01802092418074608,
-0.004328441806137562,
-0.02677667699754238,
-0.009836484678089619,
-0.004631193820387125,
-0.043035708367824554,
0.007285465020686388,
-0.01937781274318695,
-0.009943988174200058,
-0.06667199730873108,
0.008173106238245964,
-0.011469085700809956,
0.0073242830112576485,
0.00969315692782402,
0.021627729758620262,
0.007622710429131985,
-0.009493006393313408,
0.021275319159030914,
-0.020010439679026604,
-0.006540610454976559,
0.01699378341436386,
0.030051227658987045,
-0.0013299472630023956,
0.020931866019964218,
-0.014633296057581902,
-0.005190885625779629,
0.018061529844999313,
0.013975497335195541,
0.003751383163034916,
0.030207809060811996,
-0.02901684120297432,
0.0008716126903891563,
-0.008288604207336903,
0.012426557950675488,
0.01289428025484085,
0.015148920007050037,
-0.005637490190565586,
-0.031016800552606583,
-0.0005415771156549454,
0.010545557364821434,
-0.015425504185259342,
-0.0028345154132694006,
-0.003747333772480488,
-0.009218715131282806,
-0.005506583489477634,
0.006956272758543491,
0.011416381224989891,
-0.021566346287727356,
0.001365930074825883,
0.009962582029402256,
-0.023222489282488823,
-0.001010348554700613,
0.0365045964717865,
0.005590477492660284,
-0.01095398049801588,
0.015151461586356163,
0.025671817362308502,
0.031078357249498367,
0.0009874533861875534,
-0.00402284599840641,
0.025925230234861374,
0.058781370520591736,
0.019110029563307762,
-0.007533978670835495,
0.005946044344455004,
-0.008782980032265186,
0.007671497296541929,
0.0017865821719169617,
-0.0017398465424776077,
0.00718397693708539,
0.0038664762396365404,
-0.014531235210597515,
-0.006177020724862814,
-0.007522288244217634,
-0.009821109473705292,
-0.0002495450899004936,
-0.03632022440433502,
-0.007047688588500023,
0.01733337715268135,
0.00563156558200717,
0.0037336323875933886,
0.017899230122566223,
-0.027005381882190704,
-0.01804272085428238,
-0.002012135460972786,
0.011039787903428078,
-0.001800823025405407,
0.014086728915572166,
0.019726913422346115,
0.0053105661645531654,
0.0082757119089365,
0.015332846902310848,
0.028431721031665802,
0.007711339276283979,
0.011902553960680962,
0.006659542676061392,
-0.00862662959843874,
-0.0179376769810915,
-0.023984171450138092,
0.0010411720722913742,
0.001079288311302662,
-0.012373203411698341,
-0.02679987996816635,
0.005892337765544653,
0.022079916670918465,
-0.03143259137868881,
0.013788358308374882,
0.0076127746142446995,
0.029508575797080994,
-0.012135693803429604,
0.02312241680920124,
-0.014975480735301971,
-0.005921356379985809,
0.008034450933337212,
-0.011143730953335762,
0.010254165157675743,
0.008551985025405884,
0.011102790012955666,
-0.010545664466917515,
-0.0058018360286951065,
0.013817152939736843,
0.007912875153124332,
-0.008243325166404247,
0.06599242240190506,
-0.0005547353066504002,
0.01015158649533987,
0.0050995973870158195,
0.012893772684037685,
0.017590241506695747,
-0.01378567609935999,
0.032467760145664215,
-0.00578325567767024,
0.01546657644212246,
0.002223631367087364,
-0.013016865588724613,
-0.016590721905231476,
-0.02538677491247654,
0.011530695483088493,
-0.006650378927588463,
0.0033117744605988264,
0.0014651985839009285,
0.024593200534582138,
-0.00113679189234972,
0.026579193770885468,
0.0319303460419178,
0.005626733414828777,
0.03432784229516983,
-0.012783806771039963,
0.006848384626209736,
0.011045653373003006,
-0.0019282037392258644,
-0.000665467232465744,
-0.02483810856938362,
-0.02060028351843357,
-0.006311206147074699,
-0.011392059735953808,
-0.011145887896418571,
-0.010524436831474304,
-0.010763531550765038,
-0.0029410982970148325,
0.01837119646370411,
0.011248037219047546,
-0.023827025666832924,
-0.007861288264393806,
-0.0006180882919579744,
0.03628447279334068,
-0.000605282373726368,
0.012442801147699356,
0.014873547479510307,
0.01094660721719265,
0.012624246999621391,
0.012920624576508999,
0.0015360652469098568,
0.001466481015086174,
-0.01905559003353119,
-0.03242085129022598,
-0.013208535499870777,
-0.007612608373165131,
0.0030101195443421602,
0.018373075872659683,
0.01419717725366354,
-0.021393176168203354,
0.01443456206470728,
-0.01784648559987545,
0.000635246280580759,
0.004177493043243885,
0.0042413673363626,
-0.004876323975622654,
0.0016804863698780537,
-0.03551454842090607,
-0.0193772092461586,
-0.001575352856889367,
-0.018429281190037727,
-0.02697550132870674,
0.008287397213280201,
0.001499368343502283,
-0.003752104938030243,
-0.029013127088546753,
0.011723658069968224,
-0.003716385690495372,
0.0014482634142041206,
0.00034760020207613707,
0.023562047630548477,
0.021078113466501236,
0.003406379371881485,
0.006851267069578171,
-0.02723515033721924,
-0.010179365053772926,
0.011933963745832443,
0.05055404081940651,
-0.004663991276174784,
0.022111983969807625,
-0.025483105331659317,
0.021249249577522278,
0.009954911656677723,
-0.00665124598890543,
-0.016413614153862,
-0.08107864111661911,
-0.01326742209494114,
0.0060585299506783485,
-0.0374511256814003,
0.01343982107937336,
0.017671680077910423,
0.011045144870877266,
0.009389834478497505,
-0.019576845690608025,
0.0019377979915589094,
0.022590573877096176,
0.013796666637063026,
-0.0041239201091229916,
-0.025793708860874176,
-0.03484655171632767,
-0.0030953139066696167,
0.0016810002271085978,
-0.0052016545087099075,
-0.019252410158514977,
0.004651156719774008,
0.01810159720480442,
-0.010146426036953926,
0.004248326178640127,
-0.015977203845977783,
-0.025684181600809097,
0.00023987144231796265,
-0.006898021325469017,
0.0018927757628262043,
0.03885291516780853,
0.002433938207104802,
0.01569574698805809,
-0.02167380601167679,
0.015575573779642582,
-0.006330715958029032,
0.008648214861750603,
-0.019574251025915146,
0.0009393251966685057,
0.004335740581154823,
-0.0052140383049845695,
-0.017870651558041573,
-0.02278805524110794,
0.0045952582731842995,
0.017393263056874275,
0.00022889033425599337,
0.003550382098183036,
-0.0006720507517457008,
-0.0004929846618324518,
0.008357742801308632,
0.012106342241168022,
-0.006804120726883411,
-0.04483429342508316,
-0.003326795995235443,
0.020857475697994232,
0.023146990686655045,
-0.007888184860348701,
-0.006780783645808697,
0.001281351549550891,
0.0188188087195158,
-0.011539267376065254,
-0.010424086824059486,
-0.021970290690660477,
0.007968881167471409,
0.0002791844308376312,
0.004478403367102146,
-0.002471241634339094,
-0.00522332638502121,
0.021209562197327614,
-0.005986629985272884,
-0.026450112462043762,
0.011938780546188354,
0.007956570014357567,
-0.0012232952285557985,
0.00473798718303442,
-0.003004318568855524,
0.007138296961784363,
-0.0052790408954024315,
-0.014033287763595581,
-0.018640566617250443,
0.0029619440902024508,
0.017899632453918457,
-0.010957869701087475,
0.01563454605638981,
0.01086384616792202,
0.01479826308786869,
0.011698290705680847,
0.014649979770183563,
0.011534512974321842,
-0.018622126430273056,
0.0061912331730127335,
-0.01412430964410305,
0.01967247761785984,
0.014752614311873913,
-0.013977503404021263,
0.008888171054422855,
-0.02783508040010929,
-0.041813455522060394,
-0.005762074608355761,
0.0018703184323385358,
0.006715094670653343,
0.008174934424459934,
-0.020538480952382088,
-0.00235614157281816,
0.018726708367466927,
-0.007638241164386272,
-0.035037267953157425,
0.01958182081580162,
0.005369350779801607,
-0.016582265496253967,
-0.01724306493997574,
-0.010257873684167862,
0.014991670846939087,
-0.014982557855546474,
-0.004136337898671627,
0.0006184084340929985,
0.011890476569533348,
-0.014474974945187569,
-0.0014738829340785742,
0.008167794905602932,
0.07175293564796448,
0.008404669351875782,
-0.0029746191576123238,
-0.01899954117834568,
0.008935539983212948,
-0.01021405030041933,
-0.00212837103754282,
-0.008052628487348557,
0.0038393717259168625,
0.008797027170658112,
0.011735813692212105,
-0.0421365350484848,
-0.026185523718595505,
-0.02539845183491707,
0.012748319655656815,
-0.001278062118217349,
0.014475690200924873,
-0.029291074723005295,
0.013425026088953018,
0.018742993474006653,
-0.0072604273445904255,
0.03370632976293564,
-0.01763000339269638,
0.0005403263494372368,
0.011971871368587017,
-0.02316221036016941,
0.0024901041761040688,
-0.011995114386081696,
-0.006476000417023897,
0.010766690596938133,
-0.003123227972537279,
0.008755126968026161,
-0.003552423557266593,
0.0051191882230341434,
0.02506149187684059,
-0.036385778337717056,
0.04118853434920311,
-0.020034227520227432,
0.002510417951270938,
-0.010655781254172325,
-0.027476510033011436,
-0.01599017158150673,
0.009121555835008621,
0.002743181074038148,
-0.029631048440933228,
0.0059855543076992035,
-0.021985940635204315,
-0.009061777964234352,
0.01622336357831955,
0.012211335822939873,
0.0003857775591313839,
-0.0114775151014328,
0.007457575760781765,
-0.0008711630944162607,
0.01975664123892784,
0.03308403864502907,
0.0073598879389464855,
0.0009061271557584405,
-0.005973287858068943,
-0.00045507587492465973,
-0.01730620115995407,
-0.0445915088057518,
0.03441886603832245,
-0.00910719484090805,
0.019151613116264343,
-0.007878607138991356,
0.007874748669564724,
0.0006598676554858685,
-0.026892513036727905,
0.006821285933256149,
-0.017939701676368713,
0.015762992203235626,
0.006370807997882366,
-0.0034492509439587593,
-0.04417416825890541,
-0.003914757631719112,
0.011483234353363514,
-0.00991901196539402,
0.0023607336916029453,
-0.009582152590155602,
0.01877875253558159,
-0.0002498100511729717,
0.02124740369617939,
0.010847129859030247,
-0.012379110790789127,
-0.012094817124307156,
0.0026523976121097803,
-0.07413146644830704,
-0.02564217895269394,
0.003160131862387061,
-0.006406016182154417,
-0.007046818733215332,
-0.005479470826685429,
-0.018279053270816803,
0.00825454667210579,
-0.007159094326198101,
-0.009886619634926319,
0.000020597828552126884,
0.0009909137152135372,
0.0064034415408968925,
0.0002603221219033003,
0.014107583090662956,
0.01118793897330761,
-0.01638922281563282,
-0.005001750309020281,
-0.004831986501812935,
-0.0037753479555249214,
-0.010418335907161236,
-0.01614445075392723,
-0.06407232582569122,
0.005611722357571125,
0.010283629409968853,
-0.08039289712905884,
-0.022705847397446632,
0.029277164489030838,
-0.03479954972863197,
-0.0011680051684379578,
-0.005427361465990543,
-0.0027155838906764984,
-0.025252584367990494,
0.0007734799874015152,
-0.014495849609375,
-0.011472489684820175,
-0.03299204260110855,
0.020317504182457924,
0.007487498223781586,
0.019796181470155716,
-0.013353465124964714,
0.026050526648759842,
0.010448274202644825,
0.020284181460738182,
-0.025776855647563934,
0.006997375283390284,
-0.001715267775580287,
-0.007868403568863869,
-0.004477316979318857,
-0.01577667146921158,
-0.020065687596797943,
-0.013989942148327827,
0.016220737248659134,
-0.013182107359170914,
-0.0164392851293087,
0.0038237711414694786,
0.0012169843539595604,
0.015957988798618317,
0.0016878516180440784,
0.013124115765094757,
-0.01080341823399067,
0.0340183824300766,
-0.008571874350309372,
-0.0023437151685357094,
-0.006728817708790302,
-0.005097608547657728,
0.0028323503211140633,
0.02559269592165947,
0.005888361483812332,
0.0194975845515728,
-0.03417733311653137,
0.008142356760799885,
-0.0076081408187747,
0.034253060817718506,
-0.014936349354684353,
0.006594914477318525,
-0.02201349288225174,
0.012578672729432583,
-0.04009583964943886,
-0.008591845631599426,
0.0019109556451439857,
-0.013407131657004356,
0.005370021797716618,
-0.019603539258241653,
0.009268878027796745,
0.00023672310635447502,
-0.007453699596226215,
0.011290675029158592,
0.07127334177494049,
-0.016036411747336388,
0.021662652492523193,
-0.028786547482013702,
-0.003165600821375847,
0.0022961683571338654,
0.029447568580508232,
-0.022306255996227264,
-0.0142540093511343,
-0.01899959333240986,
-0.02905682846903801,
-0.009432632476091385,
-0.023553501814603806,
0.015141013078391552,
0.0068139573559165,
-0.02006022445857525,
-0.010263468138873577,
0.003064898308366537,
-0.023062990978360176,
0.02130657434463501,
-0.03424089401960373,
-0.021143533289432526,
-0.03769218176603317,
0.0027400972321629524,
0.028266847133636475,
-0.01720847189426422,
-0.027707181870937347,
-0.025964047759771347,
-0.01716439425945282,
-0.01944594457745552,
0.005285296589136124,
-0.012529166415333748,
0.005352271720767021,
-0.0056135393679142,
0.001468819915316999,
-0.021165957674384117,
0.02291066013276577,
0.00811958871781826,
0.003657946363091469,
0.030718287453055382,
0.03172191232442856,
0.001634044572710991,
-0.002174483146518469,
-0.01968713477253914,
0.017185702919960022,
-0.015841837972402573,
0.030001960694789886,
0.02749604918062687,
0.027724802494049072,
0.008035596460103989,
0.02484094351530075,
0.010193769820034504,
0.0033627627417445183,
-0.026797885075211525,
-0.00010929442942142487,
0.00428485032171011,
-0.010386676527559757,
0.006839651148766279,
0.008923864923417568,
0.01657598838210106,
-0.003112289821729064,
-0.001635202905163169,
-0.015204397961497307,
-0.016174279153347015,
0.02410827949643135,
0.006007034331560135,
0.0205844696611166,
-0.016813091933727264,
-0.018449682742357254,
0.014519215561449528,
-0.018075929954648018,
0.031782299280166626,
0.011789323762059212,
-0.03478757292032242,
0.018040047958493233,
0.02491457387804985,
0.04485424980521202,
0.003067865502089262,
-0.007487589959055185,
-0.010408058762550354,
-0.009419907815754414,
-0.006361340172588825,
0.014559014700353146,
0.020817499607801437,
-0.006096449214965105,
0.00034152029547840357,
0.034514375030994415,
-0.0041517154313623905,
-0.005116527900099754,
0.0031128013506531715,
0.0068229688331484795,
0.014852257445454597,
0.003176850499585271,
-0.014561982825398445,
0.008582299575209618,
0.033803634345531464,
0.011079341173171997,
0.0037772608920931816,
0.049362219870090485,
0.008430659770965576,
-0.017409153282642365,
-0.015555188059806824,
-0.007063138298690319,
-0.009030576795339584,
-0.011412939056754112,
-0.017672289162874222,
0.028154555708169937,
-0.013448601588606834,
-0.02021808549761772,
-0.007460503373295069,
0.03320875018835068,
0.04813683032989502,
0.018144778907299042,
0.007824227213859558,
0.02705506980419159,
0.03893091902136803,
-0.021588655188679695,
0.00016065966337919235,
-0.0009809723123908043,
-0.010294228792190552,
-0.01106390729546547,
0.00439350213855505,
-0.010353965684771538,
0.02663961425423622,
-0.04345830902457237,
-0.04412490501999855,
-0.00008524765144102275,
0.0019135575275868177,
0.0008052275516092777,
0.01806085929274559,
0.0184959527105093,
-0.015196744352579117,
-0.0039060302078723907,
-0.0041206092573702335,
0.002761279931291938,
0.024670904502272606,
-0.024163657799363136,
-0.018547531217336655,
-0.0022376433480530977,
-0.01156822219491005,
-0.016500605270266533,
-0.0012962871696799994,
-0.002181109506636858,
-0.029096515849232674,
0.007036525756120682,
-0.007251752074807882,
-0.009005308151245117,
-0.002875344827771187,
0.007169671822339296,
-0.008304629474878311,
0.00997280515730381,
0.015641409903764725,
0.00463459175080061,
-0.010078610852360725,
-0.004463285207748413,
0.020894300192594528,
0.011097446084022522,
-0.032921403646469116,
0.004423176404088736,
0.024012718349695206,
0.000059742480516433716,
-0.01693200320005417,
0.010424642823636532,
0.011908095329999924,
-0.003934066742658615,
0.0016054227016866207,
-0.013725319877266884,
0.001300070434808731,
0.007138599641621113,
-0.006178656127303839,
-0.006287247873842716,
-0.0016448176465928555,
0.019687257707118988,
-0.010865380987524986,
-0.04726557433605194,
-0.0022593908943235874,
-0.0069006094709038734,
0.013810062780976295,
-0.020772848278284073,
-0.005340011790394783,
0.00941767543554306,
0.006828707177191973,
-0.012752510607242584,
-0.0068755135871469975,
0.0012137634912505746,
-0.0037658093497157097,
-0.02446560375392437,
0.016317371279001236,
0.026085514575242996,
-0.008696254342794418,
-0.03333557769656181,
0.0164326224476099,
0.013413485139608383,
-0.0027861082926392555,
-0.02313590794801712,
-0.015092942863702774,
-0.021921515464782715,
-0.015331737697124481,
0.00039856575313024223,
0.015242839232087135,
-0.016526564955711365,
-0.0065755778923630714
] | [
0.6505045294761658,
0.08853582292795181,
-0.4336700141429901,
-0.010566533543169498,
0.19917631149291992,
0.35209906101226807,
-0.005313070025295019,
0.12482897937297821,
-0.5536947250366211,
-0.42244261503219604,
-0.06695225834846497,
-0.05820788815617561,
-0.02420540526509285,
0.30267685651779175,
-0.4249165654182434,
0.7771794199943542,
0.2748751938343048,
0.4258393943309784,
-0.07028740644454956,
-0.49991804361343384,
-0.6011724472045898,
-0.4740781784057617,
-0.022031227126717567,
0.2456306666135788,
0.02701793611049652,
-0.3285868763923645,
0.26229041814804077,
0.23295840620994568,
0.33288291096687317,
-0.10965944826602936,
0.11940962821245193,
0.26061075925827026,
0.2513849139213562,
-0.4775884449481964,
-0.1934467852115631,
-0.36289963126182556,
-0.01662994734942913,
0.1495082676410675,
0.017186341807246208,
-0.14863194525241852,
-0.10253536701202393,
-0.11537353694438934,
0.041386619210243225,
0.4614681303501129,
0.03393678739666939,
-0.9327142238616943,
-1.1843043565750122,
0.4335683286190033,
-0.06900660693645477,
0.2447197288274765,
0.49664273858070374,
0.11563404649496078,
-0.5973854064941406,
0.192885622382164,
0.09962061792612076,
0.5185896754264832,
-0.35756930708885193,
-0.1458764672279358,
0.10436434298753738,
-0.5013876557350159,
0.039553042501211166,
-0.2727007567882538,
-0.30426910519599915,
0.22526130080223083,
-0.2471977025270462,
0.5085007548332214,
0.5310301184654236,
0.45572996139526367,
-0.1585455685853958,
-0.23778995871543884,
-0.1481563001871109,
-0.24962066113948822,
-0.3425069749355316,
0.10497794300317764,
0.02109166420996189,
-0.33204832673072815,
0.09367106109857559,
-0.17657367885112762,
0.24157020449638367,
0.2248760461807251,
0.3715684711933136,
0.1651415377855301,
0.13991191983222961,
-0.2834238111972809,
0.6614284515380859,
0.2584075629711151,
0.2100834995508194,
0.576087236404419,
-0.48499685525894165,
0.12270115315914154,
0.41815778613090515,
-0.07395149022340775,
0.08139872550964355,
0.5512185096740723,
-0.16510452330112457,
0.23897390067577362,
0.3071378171443939,
-0.23869995772838593,
0.28538721799850464,
-0.005516797304153442,
-0.6398253440856934,
0.2420266717672348,
0.15375544130802155,
-0.055778633803129196,
-0.23814448714256287,
-0.15159618854522705,
-0.21985459327697754,
-0.38407817482948303,
-0.5740727782249451,
0.22030113637447357,
-0.4311486780643463,
0.06344947963953018,
-0.1919274926185608,
-0.23196209967136383,
-0.42683541774749756,
0.3246777355670929,
0.02506566420197487,
-0.8561640381813049,
0.22405023872852325,
0.2538761794567108,
0.021889325231313705,
1.193508505821228,
-0.40619680285453796,
0.481785386800766,
0.18699216842651367,
-0.005286837927997112,
0.54109126329422,
0.17207705974578857,
-0.0930088460445404,
0.4248361885547638,
0.42793911695480347,
0.49453988671302795,
-0.7157190442085266,
0.20586304366588593,
0.1632634550333023,
0.31804609298706055,
-0.08038858324289322,
0.6796438097953796,
0.27419742941856384,
-0.2614852488040924,
-0.9370068311691284,
-0.7424808144569397,
0.22954796254634857,
0.39355167746543884,
-0.030087711289525032,
0.0017760804621502757,
-0.2935117781162262,
-0.2847723960876465,
-0.1809944361448288,
-0.34732764959335327,
0.014475444331765175,
-0.22195656597614288,
-0.37172943353652954,
0.16266033053398132,
-0.1756686121225357,
0.5801271200180054,
0.5978282690048218,
-0.3005496561527252,
-0.034162260591983795,
0.41584309935569763,
0.7048861384391785,
0.3131381869316101,
-0.2542800009250641,
-0.2871197760105133,
0.25988632440567017,
0.09586720168590546,
0.10400047898292542,
0.5326120853424072,
-0.24124033749103546,
-0.3132929503917694,
-0.7728955149650574,
-0.12131103873252869,
-0.19197717308998108,
-0.9237544536590576,
0.4417089819908142,
0.23267319798469543,
0.12688396871089935,
0.17181037366390228,
0.3670646846294403,
0.5433057546615601,
-0.4768941104412079,
0.15354028344154358,
-0.3209940195083618,
-0.647955596446991,
0.02667371556162834,
-0.10764170438051224,
0.10242544114589691,
-0.1393498182296753,
0.031668003648519516,
-0.2516056299209595,
-0.6293951272964478,
-0.23978331685066223,
0.5596258044242859,
-0.5863181948661804,
0.997463583946228,
-0.5977340340614319,
-0.28306716680526733,
1.557127833366394,
0.4151608645915985,
0.23254331946372986,
-0.17358700931072235,
0.3111410439014435,
0.45805492997169495,
-0.2436039000749588,
-1.0195839405059814,
0.2318754494190216,
0.20153728127479553,
-0.03578649088740349,
-0.29297399520874023,
0.139273002743721,
0.5772585272789001,
0.16269896924495697,
-0.03842947259545326,
-0.4494565725326538,
0.2418247014284134,
0.35709095001220703,
-0.26878541707992554,
-0.19248946011066437,
-0.2088686227798462,
0.008858395740389824,
0.1815120130777359,
-0.5802129507064819,
0.4036382734775543,
0.6127336025238037,
0.23482604324817657,
0.46390095353126526,
0.7473467588424683,
-0.2204618602991104,
0.7705835103988647,
-0.571111261844635,
-0.04461021348834038,
0.030006909742951393,
0.11858092248439789,
-0.9423031806945801,
-0.20427821576595306,
-0.09625420719385147,
-0.33568820357322693,
0.18518036603927612,
-0.07797611504793167,
0.2289946973323822,
0.0932777151465416,
0.32681721448898315,
-0.7224589586257935,
0.23256444931030273,
-0.412259966135025,
-0.39432165026664734,
-0.4107860326766968,
-0.12412355840206146,
-0.8809012174606323,
-0.14041410386562347,
0.11114896088838577,
0.6297833919525146,
0.34847232699394226,
-0.5247803330421448,
-0.3034505844116211,
-0.05406011641025543,
-0.1003759354352951,
-0.3421365022659302,
0.46367719769477844,
-0.3817000687122345,
-0.1137881800532341,
0.3283121585845947,
0.3201275169849396,
0.1860465705394745,
0.13895992934703827,
-0.458811491727829,
-0.5987293720245361,
-0.6528316736221313,
0.47912725806236267,
0.5377637147903442,
0.8304575085639954,
-0.1446361243724823,
-0.5625094175338745,
0.0009644592646509409,
0.1099267452955246,
-0.742596447467804,
-0.013082695193588734,
0.7870230674743652,
-0.5716955065727234,
-0.264416366815567,
-0.013123580254614353,
0.10075899213552475,
0.6359099745750427,
-0.44723936915397644,
-0.3534453809261322,
-0.02079770341515541,
0.19457747042179108,
-0.2215327024459839,
-0.7504813075065613,
0.017995677888393402,
0.1578660011291504,
0.15493957698345184,
-0.05723227933049202,
-0.016517670825123787,
0.7146982550621033,
0.1659007966518402,
-0.1776047646999359,
0.42152372002601624,
0.42472901940345764,
-0.34099018573760986,
0.2311401516199112,
0.562175989151001,
0.11336249858140945,
-0.2825353443622589,
0.023570600897073746,
0.19212232530117035,
0.01389322429895401,
-0.21549752354621887,
-6.058960437774658,
-0.1475524753332138,
-0.07350018620491028,
-0.2380490005016327,
-0.32223308086395264,
0.0553135983645916,
0.9536052942276001,
-0.1522824764251709,
0.3253813087940216,
-0.2798842787742615,
0.8686310648918152,
0.4908379316329956,
0.23875053226947784,
-0.1263759285211563,
-0.1379750818014145,
0.002937432611361146,
0.20246976613998413,
-0.13527587056159973,
0.5708111524581909,
0.536555826663971,
-0.35593321919441223,
-0.11712469160556793,
0.004525662399828434,
0.327958881855011,
0.4472227990627289,
0.15602044761180878,
-0.9077457189559937,
0.10629364848136902,
-0.08141032606363297,
0.22172586619853973,
0.33327218890190125,
-0.5074790716171265,
0.05629948526620865,
-0.252962589263916,
-0.3157225549221039,
-0.1311711072921753,
0.15603519976139069,
-0.09147165715694427,
0.019059546291828156,
0.39040595293045044,
0.02152305655181408,
0.07338918745517731,
-0.04400591552257538,
-0.294678658246994,
-0.10221919417381287,
-0.04800590127706528,
0.07322750240564346,
0.24846303462982178,
0.12875549495220184,
0.8796133399009705,
0.029277212917804718,
0.10854900628328323,
0.3181551694869995,
0.3714970648288727,
0.1799774467945099,
-0.047606900334358215,
-0.10389627516269684,
0.26966506242752075,
-0.39385342597961426,
0.03718612715601921,
0.16618449985980988,
-0.5401502847671509,
0.27333498001098633,
-0.31368863582611084,
0.18910455703735352,
0.0415385439991951,
-0.34738123416900635,
-0.6292307376861572,
0.4862693250179291,
-0.32842886447906494,
-0.37933585047721863,
-0.019407378509640694,
0.32812681794166565,
-0.8103958964347839,
0.11442586779594421,
-0.7936514616012573,
-0.17172391712665558,
-0.006360780447721481,
0.020882677286863327,
-0.2675197720527649,
-0.1239495724439621,
-0.5282531380653381,
0.2352333962917328,
-0.44969442486763,
0.2094445526599884,
-0.094638392329216,
0.14594221115112305,
0.08348166942596436,
-0.04137154668569565,
0.596979022026062,
0.8141875267028809,
-0.4910913407802582,
0.27291664481163025,
0.369995653629303,
0.3955744802951813,
1.0087110996246338,
0.5805402398109436,
-0.14935027062892914,
0.3538229167461395,
0.2681148052215576,
0.35291600227355957,
-0.3699135184288025,
-0.2794089913368225,
-0.819492518901825,
-0.11202625930309296,
-0.21735481917858124,
0.18949395418167114,
-0.04476818069815636,
0.7606091499328613,
-0.7566777467727661,
0.5426040291786194,
-0.3055651783943176,
-0.18638281524181366,
-0.01560711394995451,
0.4936191439628601,
-0.3245561420917511,
0.15487173199653625,
0.4137631058692932,
0.4949948787689209,
-0.15183112025260925,
0.5724104046821594,
0.27671512961387634,
-0.5533238649368286,
0.4838657081127167,
0.19463589787483215,
-0.48074379563331604,
0.22799332439899445,
0.5455690622329712,
-0.42913293838500977,
-0.25411105155944824,
0.10672982782125473,
0.38472580909729004,
-0.13064412772655487,
0.0023467845749109983,
0.1004844605922699,
0.14490379393100739,
-0.04943520575761795,
-0.19400979578495026,
0.5080240964889526,
-0.07643484324216843,
0.028096061199903488,
-0.03869595751166344,
-0.37427446246147156,
0.15284036099910736,
0.26196184754371643,
0.3447590172290802,
-0.4067450761795044,
0.22916796803474426,
0.22920887172222137,
-0.37627047300338745,
-0.05771980434656143,
0.3755108416080475,
0.32234153151512146,
0.21550895273685455,
-0.8221589922904968,
-0.15118592977523804,
0.4330821931362152,
-0.08515160530805588,
-0.12418632209300995,
-0.26804304122924805,
0.4654453694820404,
-0.17795181274414062,
-1.1455799341201782,
-0.39479097723960876,
0.32583296298980713,
-0.15129676461219788,
0.3444879353046417,
-0.5788776278495789,
-0.1871568113565445,
0.3234049379825592,
-0.21159641444683075,
-0.02969689853489399,
0.07672037929296494,
0.23760713636875153,
-0.01854146085679531,
-0.1084715947508812,
-0.34479063749313354,
-0.03391468897461891,
-0.04651327803730965,
0.3153991401195526,
0.027578743174672127,
-0.015091034583747387,
-0.20932291448116302,
0.5208070874214172,
0.3052079379558563,
0.16101378202438354,
0.19686898589134216,
-0.3496249318122864,
-0.5574580430984497,
-0.22010357677936554,
0.15481781959533691,
0.12809519469738007,
0.6506909132003784,
0.17735211551189423,
0.11853370815515518,
0.03980255872011185,
0.016012858599424362,
-0.013969439081847668,
0.03013334795832634,
-0.252615749835968,
-0.04729766026139259,
0.49132513999938965,
-0.3380047678947449,
0.33496609330177307,
0.1261816769838333,
-0.2996518909931183,
0.09900061041116714,
-0.04986413195729256,
-0.26204514503479004,
-0.2620210349559784,
0.07103016972541809,
-0.45558255910873413,
-0.16135604679584503,
0.7037374377250671,
-0.41398972272872925,
-0.18164506554603577,
0.1290748566389084,
-0.004316517151892185,
-0.02641000598669052,
0.3339093327522278,
0.40182459354400635,
-0.2504061758518219,
-0.26493820548057556,
-0.16459758579730988,
-0.5412909388542175,
0.8102855682373047,
0.5787583589553833,
-0.9843382239341736,
0.08229361474514008,
-0.07343056797981262,
-0.5246427059173584,
0.02569546550512314,
0.25407418608665466,
0.1155429556965828,
-0.8768614530563354,
-0.2147890329360962,
0.29635608196258545,
-0.13999676704406738,
0.21113720536231995,
0.3189004361629486,
-0.03563101962208748,
0.6491290330886841,
-0.12129656225442886,
-0.6121916174888611,
-0.39366859197616577,
-0.041468556970357895,
0.40265893936157227,
-0.6572283506393433,
-0.17032980918884277,
0.06561639159917831,
-0.20877832174301147,
-0.17837783694267273,
0.22058139741420746,
0.2517390251159668,
0.16079877316951752,
-0.07769590616226196,
-0.28879478573799133,
-0.14412282407283783,
-0.30208858847618103,
-0.15850980579853058,
-0.13813640177249908,
-0.47941717505455017,
-0.39855319261550903,
-0.2920518219470978,
0.3413197696208954,
-0.2165147364139557,
-0.38929370045661926,
-0.2405325472354889,
-0.043712615966796875,
-0.1064639687538147,
0.02430693618953228,
-0.21317045390605927,
0.43227460980415344,
0.5416470766067505,
0.45211899280548096,
0.22341595590114594,
-0.3476043939590454,
-0.16356568038463593,
-0.5331068634986877,
0.29166650772094727,
-0.10985865443944931,
-0.8178070783615112,
-0.17064189910888672,
-0.4746977388858795,
0.33130496740341187,
-0.4876556098461151,
0.22370049357414246,
-0.10843009501695633,
0.04448840767145157,
-0.6182346343994141,
-0.24565111100673676,
0.30952081084251404,
-0.34041541814804077,
-0.45900607109069824,
0.087506502866745,
-0.016733156517148018,
0.06880976259708405,
0.15732881426811218,
0.24861940741539001,
-0.5045918226242065,
-0.783566951751709,
0.37342503666877747,
0.14089998602867126,
-0.29621416330337524,
0.2811622619628906,
-0.10643356293439865,
-0.11703207343816757,
0.3431891202926636,
-0.22640283405780792,
0.47683629393577576,
0.23474663496017456,
-0.09559956938028336,
0.19656811654567719,
0.1761918067932129,
-0.2463250309228897,
0.18661007285118103,
-0.21523185074329376,
-0.6431213021278381,
0.7320777177810669,
-0.07575608789920807,
0.355407178401947,
0.2966598868370056,
0.49897268414497375,
-0.2621310353279114,
-0.46596601605415344,
0.5126863121986389,
-0.3258752226829529,
0.47733452916145325,
-0.04809816554188728,
-0.07311057299375534,
0.2734035849571228,
0.6064904928207397,
-0.4937973618507385,
0.08222801983356476,
0.19514358043670654,
0.2148461788892746,
0.11459319293498993,
-0.564948558807373,
-0.026122374460101128,
-0.3236059248447418,
0.9021499752998352,
0.2643364369869232,
0.2773127555847168,
-0.2544717490673065,
-0.10061775892972946,
-0.18094424903392792,
-0.033395878970623016,
0.04791136458516121,
-0.22535045444965363,
0.3929503262042999,
0.11868792027235031,
-0.21331599354743958,
-0.013271825388073921,
-0.3321879208087921,
0.044311679899692535,
0.22796368598937988,
-0.33530712127685547,
-0.09374251961708069,
-0.487171471118927,
0.24025990068912506,
0.1174611821770668,
-0.06756803393363953,
-0.14676959812641144,
0.5106658339500427,
-0.05413902923464775,
-0.14719340205192566,
0.42478734254837036,
0.31770139932632446,
-0.06748095154762268,
-0.28268158435821533,
-0.3410094380378723,
-0.5262435674667358,
-0.17461639642715454,
0.5193811058998108,
0.25096720457077026,
-0.27184954285621643,
0.08984854817390442,
-0.0021406635642051697,
-0.1221017837524414,
0.4567532539367676,
-0.5026299357414246,
-0.2110038548707962,
-0.3744596838951111,
-0.1446862667798996,
0.2576054632663727,
-0.06830207258462906,
-0.44078126549720764,
0.14867538213729858,
0.22602607309818268,
-0.16436544060707092,
-0.07174889743328094,
-0.3617078959941864,
-0.01698344387114048,
0.8938174247741699,
0.024943148717284203,
-0.13166087865829468,
-0.022471891716122627,
0.5871691107749939,
0.14493106305599213,
0.2135618031024933,
0.005511249881237745,
0.01980045810341835,
-0.4027950167655945,
0.5557546615600586,
-0.3947736918926239,
0.2512310743331909,
-0.636009156703949,
-0.31681331992149353,
-0.8039817214012146,
0.20478573441505432,
0.3506896197795868,
0.32999974489212036,
-0.2192595899105072,
0.15940198302268982,
-0.29070845246315,
-0.03483167290687561,
0.7047820091247559,
-0.4107995927333832,
0.023004276677966118,
-0.5337839722633362,
-0.23084348440170288,
-0.6547935009002686,
0.4984760284423828,
0.01615011878311634,
0.19138748943805695,
-0.4898848533630371,
0.19089773297309875,
0.7227156162261963,
-0.33552154898643494,
0.4448424279689789,
-0.58426833152771,
0.11318638175725937,
-0.398031622171402,
0.3579602837562561,
-0.46398547291755676,
0.17517291009426117,
0.4781395196914673,
0.34370431303977966,
0.28270190954208374,
-0.29577070474624634,
0.2035505473613739,
-0.24748918414115906,
0.3665156066417694,
-0.23793095350265503,
0.16586215794086456,
0.056631043553352356,
0.10259513556957245,
-0.34644943475723267,
-0.3951149582862854,
0.6703954935073853,
0.011773480102419853,
-0.37676531076431274,
0.05126671865582466,
-0.12386029213666916,
-0.2261274755001068,
0.1871412694454193,
0.2736164927482605,
0.0988532155752182,
-0.032103296369314194,
-0.5088590979576111
] |
BACKGROUND: Pandemic influenza A (H1N1) virus emerged during 2009. To help clinicians triage adults with acute respiratory illness, a scoring system for influenza-like illness (ILI) was implemented at Hospital Civil de Guadalajara, Mexico. METHODS: A medical history, laboratory and radiology results were collected on emergency room (ER) patients with acute respiratory illness to calculate an ILI-score. Patients were evaluated for admission by their ILI-score and clinicians' assessment of risk for developing complications. Nasal and throat swabs were collected from intermediate and high-risk patients for influenza testing by RT-PCR. The disposition and ILI-score of those oseltamivir-treated versus untreated, clinical characteristics of 2009 pandemic influenza A (H1N1) patients versus test-negative patients were compared by Pearson's Χ(2), Fisher's Exact, and Wilcoxon rank-sum tests. RESULTS: Of 1840 ER patients, 230 were initially hospitalized (mean ILI-score = 15), and the rest were discharged, including 286 ambulatory patients given oseltamivir (median ILI-score = 11), and 1324 untreated (median ILI-score = 5). Fourteen (1%) untreated patients returned, and 3 were hospitalized on oseltamivir (median ILI-score = 19). Of 371 patients tested by RT-PCR, 104 (28%) had pandemic influenza and 42 (11%) had seasonal influenza A detected. Twenty (91%) of 22 imaged hospitalized pandemic influenza patients had bilateral infiltrates compared to 23 (38%) of 61 imaged hospital test-negative patients (p<0.001). One patient with confirmed pandemic influenza presented 6 days after symptom onset, required mechanical ventilation, and died. CONCLUSIONS: The triaging system that used an ILI-score complimented clinicians' judgment of who needed oseltamivir and inpatient care and helped hospital staff manage a surge in demand for services. | [
-0.025277061387896538,
0.017426922917366028,
-0.007102081552147865,
0.00118365662638098,
-0.005966280587017536,
0.01586258038878441,
0.008401095867156982,
0.01601545326411724,
-0.01626945100724697,
-0.028755303472280502,
-0.008999750949442387,
0.014450548216700554,
0.0011238537263125181,
0.002959365025162697,
0.019784538075327873,
-0.007012263871729374,
0.007678413763642311,
0.030970416963100433,
0.02345556765794754,
-0.004267060197889805,
-0.026206649839878082,
-0.005272118374705315,
0.010021394118666649,
0.036719679832458496,
0.0258842334151268,
0.0015055412659421563,
0.012877218425273895,
-0.006657664198428392,
-0.032979466021060944,
0.013692895881831646,
0.0033379169180989265,
0.015200233086943626,
0.005373836494982243,
0.011980859562754631,
0.006020111031830311,
-0.004190661013126373,
-0.0024900375865399837,
0.010428751818835735,
-0.021112533286213875,
-0.004194721579551697,
0.01796775311231613,
-0.016218170523643494,
0.0013519064523279667,
-0.0032049380242824554,
-0.008645884692668915,
0.04553620517253876,
-0.008965016342699528,
-0.009935983456671238,
-0.020040564239025116,
0.005963464267551899,
-0.009184977039694786,
-0.02745671384036541,
-0.005990302190184593,
0.011592467315495014,
-0.005819607060402632,
0.029531877487897873,
0.018021652474999428,
0.020288677886128426,
-0.00558685464784503,
0.01315363496541977,
0.0257833581417799,
0.0035004427190870047,
0.01455654762685299,
-0.011211875826120377,
-0.0007588817970827222,
-0.0666513442993164,
-0.013186149299144745,
0.003177145030349493,
0.010344072245061398,
-0.0008530361810699105,
-0.011197065934538841,
0.004348382819443941,
-0.0241701677441597,
-0.019152935594320297,
-0.013210250064730644,
0.025757580995559692,
0.0007454329170286655,
0.014758896082639694,
-0.01888262666761875,
-0.014252274297177792,
0.026418473571538925,
-0.0027356878854334354,
0.0055555314756929874,
0.03177788481116295,
-0.02417956292629242,
0.0027572663966566324,
-0.005061144009232521,
0.0017210548976436257,
0.009703541174530983,
-0.00691270362585783,
-0.0016032163985073566,
-0.017788749188184738,
-0.02797304280102253,
0.0009638043120503426,
-0.002605702495202422,
-0.022090252488851547,
-0.014995500445365906,
0.04355217516422272,
-0.003932533320039511,
-0.008741609752178192,
0.01249319314956665,
0.0160061027854681,
0.015052713453769684,
0.031638532876968384,
-0.014291400089859962,
0.008504469878971577,
-0.023314379155635834,
-0.012473756447434425,
0.0003623669035732746,
-0.0026006519328802824,
0.000002369750291109085,
0.00594544131308794,
0.048672888427972794,
0.01972561702132225,
-0.009502644650638103,
-0.019752822816371918,
0.008485676720738411,
0.010813813656568527,
0.0014009373262524605,
-0.006636478938162327,
0.02396274358034134,
-0.010835215449333191,
-0.005181712098419666,
0.010635673999786377,
-0.0009846927132457495,
-0.004001351073384285,
-0.004434928297996521,
-0.026552565395832062,
-0.016392197459936142,
0.0009572205599397421,
-0.0058487942442297935,
-0.008526649326086044,
-0.04166295379400253,
-0.024091292172670364,
-0.012289931997656822,
-0.00011106324382126331,
-0.01171440351754427,
0.002875528298318386,
-0.004165793769061565,
-0.011863816529512405,
-0.025457080453634262,
0.009313315153121948,
-0.0018668783595785499,
0.020286925137043,
0.014469495043158531,
0.020573493093252182,
-0.003290807828307152,
0.008306596428155899,
0.03763791173696518,
0.021436642855405807,
0.00316798547282815,
0.019527481868863106,
-0.0011343937367200851,
-0.012515083886682987,
0.00532953068614006,
0.0026503801345825195,
-0.004492759704589844,
-0.02871129661798477,
-0.012209383770823479,
0.02843744121491909,
0.013537469319999218,
-0.002303183078765869,
-0.005300598219037056,
0.007807819172739983,
0.018124757334589958,
0.00805931631475687,
0.007226178422570229,
-0.011115647852420807,
-0.01692955195903778,
0.005597099661827087,
-0.0028405352495610714,
0.012967666611075401,
-0.006873592268675566,
0.019680149853229523,
0.017011990770697594,
-0.006951163988560438,
-0.02107216790318489,
0.009558425284922123,
0.004385017789900303,
0.06594809889793396,
0.005852080415934324,
0.0027419524267315865,
0.0009910601656883955,
0.01376323401927948,
0.013481354340910912,
0.0020171510986983776,
0.025984905660152435,
-0.0038716434501111507,
-0.018040040507912636,
-0.01507155504077673,
-0.007510875817388296,
0.004438106436282396,
-0.011820968240499496,
-0.028829868882894516,
-0.0146601852029562,
0.003818285884335637,
0.011653125286102295,
0.00023259525187313557,
0.010176308453083038,
-0.011699270457029343,
0.010206908918917179,
0.014005986973643303,
0.056057874113321304,
0.021225327625870705,
-0.022184185683727264,
0.008482279255986214,
0.026960108429193497,
-0.015935949981212616,
0.009766516275703907,
0.000945746898651123,
0.003397948108613491,
-0.045981645584106445,
0.008111493661999702,
-0.009511861950159073,
-0.025099419057369232,
-0.003089634468778968,
-0.002705142367631197,
-0.0005815760232508183,
0.005339594092220068,
-0.01860194467008114,
0.000793864019215107,
0.008775619789958,
-0.050353918224573135,
0.010534947738051414,
-0.008946576155722141,
-0.005922346375882626,
0.0014042309485375881,
0.009179181419312954,
-0.000013262033462524414,
0.00601300410926342,
-0.03202083334326744,
-0.014925630763173103,
-0.01044553890824318,
-0.014388488605618477,
0.007188458926975727,
-0.03125372901558876,
0.013817977160215378,
-0.011248640716075897,
0.004910464398562908,
-0.014581732451915741,
0.006207714322954416,
-0.014805492013692856,
0.023508133366703987,
-0.007109090220183134,
0.026820067316293716,
-0.0024896138347685337,
0.030253155156970024,
-0.004160773009061813,
-0.011425435543060303,
0.013938482850790024,
0.006858309730887413,
-0.019259601831436157,
-0.004562659189105034,
-0.003249627538025379,
0.03526654094457626,
-0.01496460847556591,
-0.000565151683986187,
-0.005046606995165348,
0.025845281779766083,
-0.003286410588771105,
0.009381597861647606,
0.006583050824701786,
0.004410161636769772,
0.011111343279480934,
-0.0013161073438823223,
0.03169321268796921,
-0.015416090376675129,
-0.0002776507753878832,
0.021706944331526756,
-0.008463387377560139,
0.005791348405182362,
-0.006129218731075525,
-0.006797578185796738,
-0.08116811513900757,
-0.008244521915912628,
0.00989476591348648,
0.004990914836525917,
0.00858218502253294,
-0.021603437140583992,
0.007877063006162643,
-0.0007930160500109196,
-0.006367185618728399,
0.04549023509025574,
-0.004144251812249422,
0.0028132260777056217,
-0.00269729970023036,
-0.0031358525156974792,
-0.009632078930735588,
-0.006045670248568058,
0.009289744310081005,
-0.012140520848333836,
-0.023217106238007545,
-0.009152519516646862,
-0.014950542710721493,
-0.011306246742606163,
0.030853508040308952,
-0.0114321643486619,
-0.025162506848573685,
-0.012022835202515125,
0.01885981671512127,
0.00553480489179492,
-0.008424827829003334,
0.006499039940536022,
0.0035663070157170296,
-0.047949086874723434,
0.018981656059622765,
-0.005167786497622728,
0.003226710483431816,
0.028085367754101753,
0.025204256176948547,
-0.004216275177896023,
-0.0007226035231724381,
-0.019132550805807114,
-0.004323715344071388,
0.012670580297708511,
-0.015122247859835625,
-0.00472294120118022,
-0.006536932196468115,
0.002485847333446145,
0.0031603332608938217,
0.011908674612641335,
0.02938871458172798,
0.018101584166288376,
-0.0036753457970917225,
-0.00910758413374424,
-0.000666698906570673,
0.018660664558410645,
-0.010987368412315845,
-0.014165913686156273,
-0.018376624211668968,
0.001147791976109147,
-0.006862948648631573,
-0.0017584564629942179,
-0.028489064425230026,
0.027840506285429,
0.005750697106122971,
-0.02049887739121914,
-0.0366639718413353,
0.0016750923823565245,
0.0027552791871130466,
-0.005846234038472176,
-0.01761132851243019,
0.01629527471959591,
-0.001997401937842369,
0.004535764455795288,
0.00707748718559742,
-0.010495780035853386,
0.011789565905928612,
-0.004809767939150333,
-0.010423094034194946,
-0.007998643442988396,
-0.01585099846124649,
-0.013097323477268219,
-0.003346615005284548,
0.011320129968225956,
-0.010585639625787735,
0.021787917241454124,
-0.005205093417316675,
-0.004871211014688015,
0.016376549378037453,
0.004062896128743887,
0.01330589223653078,
-0.02068943716585636,
0.011669514700770378,
0.0077118417248129845,
-0.006541368085891008,
0.01209249533712864,
-0.026438940316438675,
-0.0020245807245373726,
0.007289617322385311,
0.006969501730054617,
0.01118086650967598,
0.007948122918605804,
-0.019697153940796852,
-0.02438870444893837,
-0.010357270017266273,
-0.011838017031550407,
-0.0048211077228188515,
0.013298719190061092,
0.004941539838910103,
-0.023210935294628143,
-0.0014110328629612923,
-0.004353677853941917,
0.02389637567102909,
0.01895591989159584,
-0.0002607923233881593,
0.0006989091634750366,
0.012376440688967705,
0.03792867809534073,
0.006705010309815407,
-0.011319618672132492,
0.07158838957548141,
-0.013421713374555111,
0.0015705148689448833,
-0.017145168036222458,
0.06645359098911285,
-0.0078123388811945915,
-0.0004933469463139772,
-0.013751695863902569,
0.009213130921125412,
-0.0014302502386271954,
0.013384541496634483,
-0.025631239637732506,
-0.0296645350754261,
-0.006833062507212162,
-0.004011906683444977,
-0.012069549411535263,
0.01510425005108118,
-0.028532810509204865,
0.014994959346950054,
-0.010731003247201443,
-0.0008458143565803766,
-0.0003508345689624548,
-0.007749069016426802,
0.0015386426821351051,
0.019251137971878052,
0.021766357123851776,
0.008674979209899902,
-0.012698118574917316,
0.0015391675988212228,
0.0005079011316411197,
0.009570034220814705,
0.030844975262880325,
-0.004971679300069809,
-0.01577984355390072,
-0.013268034905195236,
0.013882341794669628,
-0.004323256202042103,
-0.02601037360727787,
-0.0005541326245293021,
-0.006054257042706013,
-0.004776079207658768,
-0.012514336034655571,
-0.0044691916555166245,
0.007857452146708965,
0.013208543881773949,
0.0065691061317920685,
-0.005624372512102127,
-0.011361898854374886,
-0.014273555018007755,
0.005547382403165102,
-0.0016521300422027707,
0.016715630888938904,
0.007059991359710693,
0.034172870218753815,
-0.026889657601714134,
0.02974061109125614,
0.010431228205561638,
0.005190624389797449,
0.03294464945793152,
-0.02502480335533619,
-0.027223916724324226,
-0.01985161006450653,
-0.0005889972671866417,
-0.00804939679801464,
-0.01128460094332695,
-0.006436046678572893,
-0.01970500871539116,
0.01176420971751213,
-0.008552005514502525,
0.00880170613527298,
-0.002223469316959381,
-0.009582952596247196,
-0.006994093768298626,
-0.011175481602549553,
-0.01017003320157528,
-0.00954870693385601,
-0.018779434263706207,
-0.0017439578659832478,
-0.027654064819216728,
0.002944375853985548,
-0.022110437974333763,
0.002546761417761445,
-0.00869918055832386,
0.006622993852943182,
0.002113805618137121,
-0.017025073990225792,
-0.023388531059026718,
-0.07475366443395615,
-0.0327434279024601,
0.008066615089774132,
-0.007654343731701374,
0.00977492704987526,
-0.0053572445176541805,
-0.019834034144878387,
0.006878731772303581,
-0.026314331218600273,
-0.009390231221914291,
0.006502434145659208,
0.02001226507127285,
0.01213737390935421,
0.01161422859877348,
0.01927129551768303,
0.008391514420509338,
-0.007522651460021734,
0.010882549919188023,
-0.015047638677060604,
-0.00607658177614212,
0.00919337384402752,
0.005057136528193951,
-0.025059126317501068,
-0.004968579392880201,
0.005243927240371704,
-0.08041132986545563,
-0.013384631834924221,
0.015986116603016853,
-0.01605588011443615,
0.021103303879499435,
0.007686149328947067,
0.01725657656788826,
-0.0035523949190974236,
-0.007643008138984442,
-0.014341308735311031,
0.019046399742364883,
0.0024869581684470177,
0.0038998371455818415,
-0.017121579498052597,
0.02165832184255123,
-0.001995017286390066,
0.02669929713010788,
-0.007974401116371155,
0.020070703700184822,
-0.004716759081929922,
0.020564045757055283,
0.01726052165031433,
-0.006397794932126999,
0.015320719219744205,
-0.007260642945766449,
-0.005096181761473417,
-0.001969092758372426,
0.013788282871246338,
0.013939355500042439,
-0.006388836074620485,
-0.039018794894218445,
-0.012467329390347004,
0.0006998465396463871,
0.010184988379478455,
0.018929433077573776,
-0.00852159596979618,
0.038749899715185165,
-0.019543424248695374,
0.019626054912805557,
0.008694367483258247,
-0.007333447691053152,
0.021297261118888855,
-0.01443721167743206,
0.010310453362762928,
0.020923851057887077,
0.02338089793920517,
0.010265793651342392,
-0.00842270813882351,
0.01067716907709837,
-0.0022312812507152557,
0.0044703674502670765,
-0.016031451523303986,
0.004447223152965307,
0.012082114815711975,
0.005562732927501202,
-0.0006562524940818548,
0.00020960287656635046,
0.025201864540576935,
-0.000003177439793944359,
0.02166963368654251,
-0.015550404787063599,
0.03539595007896423,
0.0034520518966019154,
0.0710696429014206,
-0.038659512996673584,
0.035414326936006546,
0.0051942006684839725,
-0.024329774081707,
0.0038369079120457172,
0.014969941228628159,
0.007356239482760429,
-0.024474414065480232,
-0.016203273087739944,
0.013197764754295349,
-0.008200358599424362,
0.013405896723270416,
0.009051868692040443,
-0.005863688420504332,
0.008963129483163357,
0.008869107812643051,
-0.022114526480436325,
-0.040125563740730286,
-0.0009618690237402916,
0.007433236110955477,
-0.013837326318025589,
-0.015237612649798393,
-0.0035202179569751024,
0.038330599665641785,
0.012234495021402836,
-0.014552455395460129,
0.015625502914190292,
-0.00980501901358366,
0.0062191844917833805,
-0.014405561611056328,
-0.003172507043927908,
0.009374226443469524,
-0.003496337914839387,
0.017880994826555252,
-0.015876729041337967,
0.017876841127872467,
0.01648775115609169,
0.009877701289951801,
0.01097789965569973,
0.034192197024822235,
-0.016702543944120407,
0.0005821228260174394,
0.012302075512707233,
0.025587048381567,
-0.032996900379657745,
0.010219544172286987,
0.02949908748269081,
0.004894697107374668,
0.018542630597949028,
-0.04094164818525314,
0.0009292443282902241,
-0.005120663903653622,
0.0025460529141128063,
-0.001734190620481968,
0.0132666677236557,
0.011105673387646675,
0.01921343058347702,
-0.015575489029288292,
-0.027432721108198166,
-0.008715720847249031,
-0.010882629081606865,
0.017432481050491333,
-0.015305890701711178,
0.004463255871087313,
-0.0021241153590381145,
0.015460453927516937,
-0.01818813756108284,
-0.02627890184521675,
0.0043495455756783485,
-0.01663922518491745,
0.02636091224849224,
0.004666532389819622,
0.001727771945297718,
0.030355770140886307,
0.037806011736392975,
0.040704526007175446,
0.0010266681201756,
0.002179039642214775,
0.018346253782510757,
-0.013181972317397594,
-0.011025890707969666,
0.02165844850242138,
-0.007854592055082321,
-0.024785224348306656,
-0.0016424631467089057,
0.004801834002137184,
-0.01449209451675415,
-0.005564824212342501,
0.008722847327589989,
0.0013805595226585865,
0.009572375565767288,
-0.0003040676238015294,
0.007767202332615852,
0.018173083662986755,
0.0350576713681221,
0.0058605726808309555,
0.005524143110960722,
0.013871433213353157,
-0.0017466888530179858,
0.001429884578101337,
0.012920499779284,
-0.0006843240698799491,
0.003664714749902487,
0.017740463837981224,
0.002528528915718198,
-0.005799618549644947,
-0.004715543705970049,
-0.005207385402172804,
0.025196921080350876,
-0.029465794563293457,
0.0006314055062830448,
0.04295501485466957,
0.01156650297343731,
-0.0030095605179667473,
0.0001608673483133316,
-0.00017570285126566887,
0.022670093923807144,
-0.0008331821300089359,
-0.011309338733553886,
-0.008105184882879257,
-0.019902732223272324,
0.023876000195741653,
0.047492071986198425,
-0.00860633235424757,
0.0017270934768021107,
-0.004720625001937151,
-0.028774600476026535,
-0.007191088050603867,
-0.024682756513357162,
0.019675521180033684,
-0.007704295217990875,
-0.018091902136802673,
0.0011078176321461797,
-0.009159017354249954,
0.0023640100844204426,
0.007894494570791721,
0.021030709147453308,
-0.021769532933831215,
0.008357536047697067,
-0.022426817566156387,
-0.008310618810355663,
0.003921263851225376,
-0.03397783637046814,
0.010778195224702358,
-0.005222117528319359,
0.00004805810749530792,
0.007820159196853638,
0.007935864850878716,
0.02368299849331379,
0.0035250517539680004,
0.012697145342826843,
0.006969966925680637,
-0.006618708837777376,
0.02208035998046398,
-0.006223807577043772,
0.008548039011657238,
-0.01354697160422802,
-0.021103639155626297,
0.010567867197096348,
-0.010313304141163826,
-0.0015252328012138605,
0.022013453766703606,
-0.0016561290249228477,
-0.014967117458581924,
-0.013145273551344872,
0.015047523193061352,
0.011154968291521072,
0.010080374777317047,
-0.008099239319562912,
-0.015845471993088722,
-0.019613705575466156,
-0.0015045213513076305,
0.018735263496637344,
0.006852800492197275,
-0.017206532880663872,
0.011190319433808327,
0.009181603789329529,
-0.026621777564287186,
0.01775931753218174,
-0.004408086650073528,
-0.009888870641589165,
0.01366297248750925,
-0.009503168985247612,
-0.006072948221117258,
-0.008820788934826851,
-0.01457980927079916,
0.02200791984796524,
0.003522745566442609,
0.0012701191008090973,
-0.009124575182795525,
-0.007776682730764151,
-0.016745878383517265,
0.017458830028772354,
-0.0015329568414017558,
-0.013282370753586292,
-0.039839841425418854,
-0.024899814277887344,
0.00723572401329875,
0.01412560697644949,
0.004891802091151476,
0.0057295262813568115
] | [
0.2729889452457428,
0.11406316608190536,
-0.2736007571220398,
0.1686813235282898,
-0.013480542227625847,
0.27419084310531616,
0.16056175529956818,
0.15380653738975525,
-0.09499156475067139,
-0.5053436756134033,
0.42251279950141907,
-0.05710082873702049,
-0.04288579151034355,
0.18527793884277344,
0.07263567298650742,
0.2889586389064789,
0.29467031359672546,
0.24015215039253235,
-0.4720611572265625,
-0.15724563598632812,
-0.19439062476158142,
-0.5089578032493591,
-0.10751446336507797,
0.27385878562927246,
-0.01131676509976387,
0.05038123577833176,
0.12352101504802704,
0.012027877382934093,
0.42387405037879944,
-0.24769675731658936,
0.09996344894170761,
0.4032611846923828,
0.18096260726451874,
-0.22431668639183044,
-0.17032159864902496,
0.02142772451043129,
-0.3547115921974182,
0.15252827107906342,
-0.011963395401835442,
-0.523220419883728,
-0.02301144041121006,
-0.24007193744182587,
-0.21610301733016968,
0.4322967827320099,
-0.14710117876529694,
-0.7749816179275513,
-1.4794857501983643,
0.45094534754753113,
-0.29168885946273804,
0.07847119122743607,
0.25740763545036316,
-0.02341494709253311,
0.08009398728609085,
0.24552668631076813,
-0.03125502169132233,
0.3784315586090088,
-0.3148789703845978,
0.013366498984396458,
0.2671583890914917,
-0.027332346886396408,
0.3401246964931488,
-0.17141158878803253,
0.32656458020210266,
0.1959371268749237,
-0.43138590455055237,
0.48978865146636963,
0.33574438095092773,
0.005310676526278257,
0.020277556031942368,
-0.4120752215385437,
-0.04281662777066231,
-0.28171733021736145,
-0.33319368958473206,
-0.09207968413829803,
-0.04762369021773338,
-0.2826855778694153,
0.17177976667881012,
-0.38340404629707336,
0.16910578310489655,
0.5393502712249756,
-0.3024809658527374,
0.05173569917678833,
0.1823953092098236,
-0.6044878363609314,
0.7396567463874817,
0.09583712369203568,
-0.29784947633743286,
0.43542054295539856,
-0.2904263436794281,
-0.1640276461839676,
0.16454391181468964,
-0.26441651582717896,
0.733421266078949,
0.479099839925766,
-0.10510449856519699,
0.5263885259628296,
0.16019392013549805,
-0.04879148304462433,
0.23299534618854523,
-0.22715260088443756,
-0.2489190250635147,
0.17858104407787323,
-0.14693602919578552,
0.011440848931670189,
-0.29119178652763367,
-0.14514099061489105,
-0.08805497735738754,
-0.23104654252529144,
-0.610409140586853,
-0.013274922966957092,
-0.23663710057735443,
-0.0668855831027031,
-0.052585773169994354,
-0.11632020026445389,
-0.060524407774209976,
0.21770216524600983,
0.3728608787059784,
-0.27200260758399963,
0.21297910809516907,
0.23311609029769897,
-0.4706699848175049,
0.7560000419616699,
-0.20143009722232819,
0.6424182653427124,
-0.07687968760728836,
0.32286620140075684,
0.4935268759727478,
0.20802780985832214,
-0.2679339349269867,
0.4312189817428589,
-0.09098473936319351,
0.43106168508529663,
-0.17815758287906647,
-0.09358598291873932,
0.12863171100616455,
-0.21154363453388214,
-0.06967835873365402,
0.5177938342094421,
-0.01944955252110958,
-0.18517838418483734,
-0.4912775158882141,
-0.6978449821472168,
-0.4014551043510437,
0.15292218327522278,
-0.1643257886171341,
-0.6480643153190613,
-0.3086562156677246,
-0.07804121822118759,
0.1834271103143692,
-0.32745420932769775,
-0.024231452494859695,
-0.3669748306274414,
-0.3917209208011627,
0.03509737551212311,
-0.04364903271198273,
0.4335964620113373,
-0.3173769414424896,
-0.21220819652080536,
0.2650005519390106,
0.17950473725795746,
0.5668047070503235,
0.38337060809135437,
-0.46369224786758423,
-0.3264624774456024,
0.10678578913211823,
-0.021664166823029518,
-0.003921376075595617,
0.5673544406890869,
-0.019114572554826736,
-0.1655433624982834,
-0.2957710325717926,
-0.30978283286094666,
-0.05827643349766731,
-0.4563847780227661,
-0.21444858610630035,
0.09976840764284134,
0.40350013971328735,
0.035474639385938644,
-0.05137690156698227,
0.5857727527618408,
-0.6118069887161255,
-0.15270128846168518,
-0.10543011128902435,
-0.5128839015960693,
0.15829961001873016,
0.037095148116350174,
0.07417093962430954,
0.11394103616476059,
-0.15300515294075012,
-0.17791494727134705,
-0.1591290533542633,
-0.06182195246219635,
0.35366007685661316,
-0.746619701385498,
1.12174391746521,
-0.27700725197792053,
-0.10989262163639069,
1.3828260898590088,
0.16581784188747406,
0.17512571811676025,
0.16710206866264343,
0.24718248844146729,
0.8477724194526672,
-0.18445074558258057,
-0.42818009853363037,
0.09719108045101166,
0.2607312500476837,
-0.09226967394351959,
-0.46732547879219055,
0.19148974120616913,
0.44376322627067566,
0.013046875596046448,
-0.10358992964029312,
-0.054508887231349945,
0.15440119802951813,
0.29362764954566956,
-0.311866819858551,
0.13414287567138672,
0.416996031999588,
-0.02668207883834839,
0.39248424768447876,
-0.642039954662323,
0.048721231520175934,
0.4326549768447876,
-0.04090740159153938,
0.4420405924320221,
0.5250987410545349,
0.12294352054595947,
1.1224160194396973,
-0.9400579333305359,
0.2714875042438507,
-0.3397102355957031,
0.44381383061408997,
-0.7019014358520508,
-0.3855290114879608,
-0.05630366876721382,
-0.16603206098079681,
-0.18923133611679077,
0.15440654754638672,
0.48977184295654297,
0.3235340416431427,
0.3738250136375427,
-0.3536614179611206,
-0.007267782464623451,
0.33814719319343567,
-0.4093764126300812,
-0.17682206630706787,
-0.3248674273490906,
-0.4450880289077759,
0.18163178861141205,
0.016709042713046074,
0.48290249705314636,
0.07233171164989471,
-0.5189827680587769,
0.0035166528541594744,
0.07274740189313889,
0.11485578119754791,
-0.3947223424911499,
0.1682870090007782,
-0.2862493693828583,
0.27983084321022034,
0.264043927192688,
0.48543792963027954,
0.17170706391334534,
0.3829381465911865,
-0.5526447892189026,
-0.5451525449752808,
-0.6790741086006165,
0.3516918122768402,
0.2069104164838791,
1.1595379114151,
0.19458678364753723,
-0.14113429188728333,
0.02307455614209175,
-0.033058833330869675,
-0.8443639874458313,
0.3462235927581787,
1.0115739107131958,
-0.7727648615837097,
-0.355187326669693,
-0.24440689384937286,
-0.09358271956443787,
0.5448350310325623,
-0.3802223801612854,
-0.18786995112895966,
-0.44068676233291626,
-0.14153815805912018,
-0.4350540041923523,
-0.4959068298339844,
-0.009761257097125053,
-0.042786773294210434,
0.700907289981842,
0.004408723674714565,
0.0015851600328460336,
0.47396624088287354,
-0.017049044370651245,
0.011725714430212975,
0.44383174180984497,
0.5567788481712341,
-0.26624131202697754,
-0.2746751606464386,
0.5154772400856018,
-0.17179423570632935,
-0.20887154340744019,
-0.0032842562068253756,
0.36573535203933716,
-0.3924500346183777,
-0.1362951397895813,
-6.21745491027832,
0.20372143387794495,
-0.17359967529773712,
-0.23795096576213837,
-0.3582301735877991,
0.09005376696586609,
0.9623236656188965,
0.2908570468425751,
0.2763947546482086,
0.04179156571626663,
0.6599253416061401,
0.34029972553253174,
0.010542385280132294,
-0.040998972952365875,
-0.11044736951589584,
0.21880538761615753,
0.0130624920129776,
0.10799463838338852,
-0.051709096878767014,
-0.09739509224891663,
-0.20084142684936523,
-0.19972103834152222,
-0.0391695611178875,
0.7191822528839111,
0.3997560441493988,
0.10919133573770523,
-0.8358116745948792,
0.4017695188522339,
-0.4284982681274414,
0.32166850566864014,
0.4764378070831299,
-0.538901150226593,
-0.12758202850818634,
0.10883356630802155,
-0.2881464660167694,
0.006468446459621191,
0.2913634777069092,
-0.11519849300384521,
-0.036527976393699646,
-0.17437495291233063,
-0.012141370214521885,
0.29022088646888733,
-0.3261326253414154,
-0.5291082262992859,
-0.05945228785276413,
-0.18336357176303864,
0.13140493631362915,
0.2901916801929474,
-0.026066552847623825,
0.7195378541946411,
0.03394920751452446,
0.059850916266441345,
-0.3533481955528259,
0.6647536158561707,
0.0782913938164711,
-0.07123953104019165,
0.15326572954654694,
0.24671636521816254,
-0.3627740740776062,
0.2030065506696701,
0.12378880381584167,
0.0573134683072567,
0.4753403663635254,
-0.6503457427024841,
0.23733897507190704,
0.1609635055065155,
-0.6236441135406494,
-0.6524097919464111,
0.01912974752485752,
0.23985400795936584,
-0.2314525842666626,
0.1111966073513031,
0.26067617535591125,
-0.7231253981590271,
0.0023500702809542418,
-0.3812865614891052,
0.2807771861553192,
0.01652115397155285,
-0.14037775993347168,
-0.32367363572120667,
-0.03718274459242821,
-0.2711479663848877,
0.4365767538547516,
-0.25362256169319153,
-0.1402963399887085,
0.26749593019485474,
0.29175490140914917,
-0.3838736414909363,
-0.10409336537122726,
0.4029615521430969,
0.6320574879646301,
-0.29014304280281067,
-0.0438508503139019,
0.27719905972480774,
0.10100658237934113,
0.6606706976890564,
0.25878265500068665,
0.05912904068827629,
0.30026280879974365,
-0.0133972754701972,
0.8931964635848999,
-0.3323139250278473,
-0.4755571484565735,
-1.049121379852295,
0.06744476407766342,
-0.0518486350774765,
-0.481200248003006,
-0.17151814699172974,
0.9364058971405029,
-0.8459724187850952,
-0.29005011916160583,
-0.055352531373500824,
-0.2384682595729828,
-0.2395087331533432,
0.35511672496795654,
-0.46288031339645386,
0.31819015741348267,
0.33488762378692627,
0.4803856909275055,
-0.14757734537124634,
0.3174596428871155,
0.2522847354412079,
-0.0896889865398407,
0.277305543422699,
0.6544504761695862,
-0.2707102596759796,
0.1852472424507141,
0.41127273440361023,
-0.46248769760131836,
-0.25257599353790283,
-0.06679615378379822,
0.34089818596839905,
-0.32042843103408813,
0.017891518771648407,
0.32424411177635193,
-0.018601056188344955,
-0.8601589798927307,
-0.22479496896266937,
0.7280541062355042,
0.208133727312088,
-0.039844054728746414,
-0.21217775344848633,
-0.1612098217010498,
-0.2371654212474823,
0.43452349305152893,
0.004505496937781572,
-0.20098380744457245,
-0.2961604595184326,
-0.16362228989601135,
-0.2092810869216919,
0.16996778547763824,
0.05526256561279297,
0.25986248254776,
0.1652524620294571,
-0.9622589349746704,
0.3265465199947357,
0.8583996891975403,
0.08982782065868378,
-0.2737634778022766,
-0.3658636808395386,
0.5368264317512512,
0.1206095889210701,
-0.9145399332046509,
-0.07850587368011475,
0.3406928777694702,
-0.5831719040870667,
0.20544594526290894,
-0.3109467327594757,
-0.06648653000593185,
0.03940437361598015,
-0.022893432527780533,
-0.5065203905105591,
0.02942461147904396,
0.23292230069637299,
-0.04713337495923042,
0.11888663470745087,
-0.40765056014060974,
0.06729673594236374,
-0.1970672458410263,
0.5078306198120117,
0.2453191876411438,
-0.4263390898704529,
-0.4934179186820984,
0.4631260335445404,
0.48757973313331604,
0.502084493637085,
0.21960587799549103,
-0.44759654998779297,
-0.3852881193161011,
-0.045712102204561234,
0.3682381808757782,
0.09436054527759552,
0.4063962996006012,
-0.14017358422279358,
-0.014329244382679462,
-0.17606566846370697,
-0.15124033391475677,
0.08398139476776123,
-0.127607524394989,
-0.21814168989658356,
0.00021556562569458038,
0.17332462966442108,
-0.3032202124595642,
0.05984111502766609,
0.11128049343824387,
-0.29147085547447205,
-0.3399232029914856,
0.013196919113397598,
0.12174248695373535,
-0.4591924548149109,
-0.016104334965348244,
-0.47496187686920166,
-0.31812915205955505,
0.47870954871177673,
-0.01824766770005226,
0.20999214053153992,
0.1486896127462387,
-0.37309229373931885,
-0.19418412446975708,
0.2665849030017853,
0.05813764035701752,
0.16516070067882538,
-0.12876324355602264,
-0.04572838544845581,
-0.36217114329338074,
0.8685879707336426,
0.6424717307090759,
-0.86305832862854,
-0.17777271568775177,
0.13078361749649048,
-0.2766740620136261,
0.025849701836705208,
0.20593397319316864,
0.39188823103904724,
-0.8793803453445435,
-0.21193614602088928,
-0.12167824059724808,
-0.3399217426776886,
0.045570049434900284,
0.5988113284111023,
0.0030216160230338573,
0.14077910780906677,
-0.06663674116134644,
-0.5313868522644043,
0.06269106268882751,
0.12368754297494888,
0.09232357144355774,
-0.5564252734184265,
-0.046847473829984665,
0.07095970213413239,
-0.2473306655883789,
-0.40112853050231934,
0.10936235636472702,
-0.182847261428833,
0.3711865544319153,
0.04885830730199814,
-0.07531442493200302,
-0.18832246959209442,
-0.23282261192798615,
-0.14840443432331085,
-0.2780816853046417,
-0.4047701060771942,
-0.3477402329444885,
-0.22429750859737396,
0.008011840283870697,
-0.20854651927947998,
-0.3497779965400696,
-0.10190877318382263,
0.023147080093622208,
-0.35978811979293823,
-0.04875022917985916,
-0.2758226990699768,
0.8221282362937927,
0.662854790687561,
0.026732999831438065,
0.13811355829238892,
-0.4312134087085724,
0.1919453889131546,
-0.13441677391529083,
0.5643566250801086,
-0.6226335763931274,
-0.6662253141403198,
0.22227157652378082,
-0.020435815677046776,
0.30029988288879395,
-0.23455879092216492,
0.011234250850975513,
-0.13645626604557037,
-0.02357541397213936,
-0.3539557456970215,
0.008572420105338097,
0.24514415860176086,
-0.43245720863342285,
-0.17339302599430084,
-0.03509898856282234,
0.05100589990615845,
0.06854205578565598,
0.6078715920448303,
0.07983993738889694,
-0.2644045650959015,
-0.2210698127746582,
0.6935344338417053,
0.2438717782497406,
-0.4735333323478699,
0.1626470983028412,
-0.11137586086988449,
0.43520885705947876,
0.4999987781047821,
-0.237846240401268,
0.014082535170018673,
0.33126509189605713,
-0.024404294788837433,
0.18563035130500793,
0.19735372066497803,
-0.5198196768760681,
0.22751212120056152,
-0.16227656602859497,
-0.432691752910614,
0.508345365524292,
-0.16797661781311035,
0.1518988013267517,
0.6535133719444275,
0.2671455144882202,
-0.10635156184434891,
-0.39626196026802063,
0.6784927248954773,
-0.09290270507335663,
0.5157961249351501,
-0.21357537806034088,
0.20792749524116516,
0.8194190859794617,
0.4588274359703064,
-0.15444059669971466,
-0.043847180902957916,
-0.06908688694238663,
0.3128695487976074,
0.07685162127017975,
-0.9042152166366577,
-0.33958399295806885,
0.09613481163978577,
0.9091470837593079,
0.33120855689048767,
-0.24678708612918854,
-0.15293999016284943,
-0.11032091826200485,
0.22217987477779388,
-0.10194385796785355,
0.19889536499977112,
0.21568375825881958,
0.18391741812229156,
-0.09781745076179504,
0.09062738716602325,
0.12521997094154358,
0.1972121000289917,
-0.06956379115581512,
-0.09804937243461609,
-0.06054692342877388,
-0.12876610457897186,
-0.5652260780334473,
-0.11266445368528366,
0.1394919902086258,
0.17720842361450195,
0.16528764367103577,
0.40324530005455017,
-0.25014176964759827,
0.13259853422641754,
0.23667410016059875,
0.14504681527614594,
-0.10065080225467682,
-0.30537834763526917,
0.056495554745197296,
-0.43915054202079773,
-0.48277419805526733,
0.5525760650634766,
0.38107582926750183,
-0.1755332052707672,
0.18405786156654358,
-0.014828002080321312,
-0.08684232085943222,
0.46387484669685364,
-0.16194701194763184,
-0.34339842200279236,
-0.242671936750412,
-0.23041141033172607,
-0.09708470106124878,
-0.15287967026233673,
-0.2688122093677521,
0.2686968147754669,
0.3701157569885254,
0.26253265142440796,
-0.03409119322896004,
-0.5604934692382812,
0.24149000644683838,
0.28182488679885864,
-0.18609938025474548,
-0.06044106185436249,
-0.056468237191438675,
0.36218464374542236,
0.16706639528274536,
0.08486881107091904,
-0.12998194992542267,
-0.10626254230737686,
-0.14366832375526428,
0.029604412615299225,
-0.4540029466152191,
0.6262690424919128,
-0.46470656991004944,
0.11673914641141891,
-0.7665219306945801,
-0.053585782647132874,
0.7502430081367493,
0.12212307006120682,
-0.19495166838169098,
-0.12697447836399078,
-0.20353133976459503,
-0.28137072920799255,
0.4747580587863922,
-0.22547312080860138,
-0.1881255805492401,
-0.39581820368766785,
-0.33251869678497314,
-0.7293837666511536,
-0.04302850365638733,
-0.1492646485567093,
0.044719770550727844,
-0.11697050929069519,
0.29377615451812744,
0.5460588335990906,
-0.0406637005507946,
0.6963996291160583,
-0.0554933026432991,
-0.27755287289619446,
-0.565475583076477,
0.17354851961135864,
-0.3264752924442291,
0.2953868806362152,
0.05388646200299263,
0.6620423197746277,
0.2860071659088135,
-0.18272440135478973,
0.381736159324646,
-0.2581978738307953,
-0.04708519205451012,
0.12259802222251892,
-0.08886480331420898,
0.23607660830020905,
0.06897516548633575,
-0.1828289031982422,
-0.27768051624298096,
0.42570894956588745,
0.05779685825109482,
-0.10530799627304077,
-0.183602973818779,
0.09681855142116547,
-0.2434675097465515,
0.14513705670833588,
0.17359080910682678,
-0.6692925095558167,
0.03636852651834488,
-0.3809419870376587
] |
We report acute encephalopathy associated with influenza A infection in 3 adults. We detected high cerebrospinal fluid (CSF) and plasma concentrations of CXCL8/IL-8 and CCL2/MCP-1 (CSF/plasma ratios >3), and interleukin-6, CXCL10/IP-10, but no evidence of viral neuroinvasion. Patients recovered without sequelae. Hyperactivated cytokine response may play a role in pathogenesis. | [
-0.02584248036146164,
0.01681980863213539,
-0.004754616878926754,
0.026323575526475906,
0.006924166344106197,
-0.0075210221111774445,
0.008901216089725494,
-0.013009659014642239,
-0.02040652371942997,
-0.000013625622159452178,
0.007422236260026693,
0.0167249646037817,
-0.000477105233585462,
0.026146581396460533,
-0.016852887347340584,
-0.02720174752175808,
-0.019321057945489883,
0.04245396703481674,
0.009931582026183605,
0.02747434191405773,
-0.009745308198034763,
-0.026866063475608826,
0.012377253733575344,
0.004973218310624361,
0.006476834882050753,
-0.0013205527793616056,
0.022581269964575768,
-0.026363911107182503,
0.02296181209385395,
-0.0032786161173135042,
0.027710970491170883,
0.01140789408236742,
-0.0036311859730631113,
0.022485995665192604,
-0.002032887190580368,
-0.006285665091127157,
-0.012974916957318783,
0.03425724804401398,
0.00327478745020926,
-0.001920850481837988,
-0.006191738415509462,
-0.015177165158092976,
0.00335118779912591,
0.0007464936934411526,
-0.012596734799444675,
0.030602112412452698,
-0.015545422211289406,
-0.008085676468908787,
0.016057834029197693,
0.009138410910964012,
-0.00537475012242794,
-0.039663929492235184,
-0.018916193395853043,
0.001315596979111433,
-0.007697962690144777,
0.0015904821921139956,
0.0224603358656168,
0.020124327391386032,
-0.024314584210515022,
-0.004815460182726383,
-0.008029756136238575,
0.0032530357129871845,
0.011722637340426445,
-0.0010174780618399382,
0.017589356750249863,
-0.06562093645334244,
0.022716008126735687,
0.00945610087364912,
0.01445950660854578,
0.002731206826865673,
-0.0010632568737491965,
0.015618575736880302,
-0.001266836072318256,
0.009355505928397179,
-0.014218763448297977,
-0.019934799522161484,
-0.011689678765833378,
0.012034633196890354,
-0.030327940359711647,
-0.002757770475000143,
-0.003252523485571146,
-0.009200045838952065,
0.0011722594499588013,
0.019326774403452873,
0.007284415885806084,
-0.010831463150680065,
-0.03476792201399803,
0.009363752789795399,
0.020175877958536148,
-0.012108707800507545,
-0.00949232280254364,
-0.002681730082258582,
-0.03462298959493637,
0.007822874933481216,
0.019369445741176605,
-0.012737584300339222,
-0.037096887826919556,
-0.009526598267257214,
-0.012960871681571007,
-0.025094101205468178,
-0.02467838115990162,
0.019296204671263695,
0.018967771902680397,
-0.01011546328663826,
-0.002667408436536789,
0.0060700043104588985,
-0.017965279519557953,
-0.005587927997112274,
0.03504006937146187,
0.011583390645682812,
-0.006010629702359438,
-0.03731899335980415,
0.001852822257205844,
0.00895268376916647,
0.023036735132336617,
0.010170772671699524,
0.004125797655433416,
0.025852074846625328,
0.00428776815533638,
-0.04855189844965935,
0.0035404108930379152,
-0.014330408535897732,
0.0007177382940426469,
-0.047701895236968994,
0.003122093388810754,
-0.040806692093610764,
-0.0012600250774994493,
-0.007725851610302925,
0.012112163007259369,
-0.009307914413511753,
-0.0036304560489952564,
0.024220511317253113,
-0.021895408630371094,
0.0002660816244315356,
-0.017141953110694885,
0.008434176445007324,
-0.017518572509288788,
-0.00006107064837124199,
-0.014332704246044159,
-0.029069939628243446,
-0.039379216730594635,
0.012569477781653404,
-0.0005000561359338462,
0.02008170634508133,
-0.007202609907835722,
0.004506542347371578,
-0.014836842194199562,
-0.0017819184577092528,
-0.00880349799990654,
-0.016487546265125275,
0.033357199281454086,
-0.003543704282492399,
0.0003785355656873435,
-0.01770416833460331,
0.012418126687407494,
-0.0010799795854836702,
-0.0018718193750828505,
-0.04051684960722923,
-0.0032326558139175177,
0.03206963464617729,
0.006518966052681208,
-0.013189727440476418,
0.02282501384615898,
0.014739107340574265,
0.01085110753774643,
0.02628176286816597,
-0.006025708746165037,
-0.007035129703581333,
0.00518734659999609,
0.00488891638815403,
-0.0035864419769495726,
0.028206754475831985,
-0.04217902943491936,
0.006773717701435089,
-0.013110807165503502,
-0.008247671648859978,
0.02103053219616413,
0.004635298158973455,
0.006411566399037838,
0.06547317653894424,
-0.02071256935596466,
0.029510045424103737,
-0.008146986365318298,
0.008041921071708202,
0.014402846805751324,
-0.03901419788599014,
0.03037249855697155,
-0.007447286043316126,
0.013179284520447254,
-0.016336265951395035,
0.0101224509999156,
-0.0052835773676633835,
0.0043232981115579605,
-0.029597323387861252,
-0.010819834657013416,
0.001600874587893486,
-0.0009719742811284959,
0.010047247633337975,
0.0011555138044059277,
-0.006129462271928787,
0.015571201220154762,
-0.024318447336554527,
0.0368797667324543,
-0.0288002397865057,
0.016213735565543175,
0.00477984081953764,
0.03654948249459267,
0.0042497809045016766,
-0.05442936718463898,
-0.025851840153336525,
0.018481818959116936,
-0.013407154940068722,
-0.004732928704470396,
-0.01175838615745306,
-0.007513586897403002,
0.007200371474027634,
-0.010862716473639011,
0.01884765923023224,
-0.009786448441445827,
-0.018694769591093063,
0.011497311294078827,
0.002190204570069909,
-0.002042467938736081,
0.018175827339291573,
0.01702396385371685,
-0.02254600077867508,
0.01691761612892151,
0.013621675781905651,
0.0169798843562603,
-0.001348635065369308,
-0.01954946294426918,
-0.02997252531349659,
-0.017576683312654495,
0.004143312573432922,
0.001942644827067852,
-0.013210500590503216,
0.021835993975400925,
-0.02705932781100273,
0.001606728765182197,
-0.023846998810768127,
0.00018482371524441987,
-0.007424250710755587,
-0.008398262783885002,
0.004627157002687454,
0.019272465258836746,
0.017378374934196472,
0.027031421661376953,
0.003865818027406931,
-0.0014850591542199254,
-0.001583256758749485,
0.013166661374270916,
0.005197001621127129,
-0.015478567220270634,
-0.04416630417108536,
-0.0027743298560380936,
-0.022925840690732002,
0.020617609843611717,
0.016943421214818954,
0.028829826042056084,
0.02916751801967621,
0.01463211141526699,
0.0027553862892091274,
-0.0008599235443398356,
0.030885549262166023,
-0.025172900408506393,
-0.004935581237077713,
0.00763430492952466,
0.003871857887133956,
0.008615019731223583,
0.0330766960978508,
0.009760436601936817,
-0.0026289583183825016,
-0.01578149013221264,
-0.08128225058317184,
-0.015314087271690369,
-0.030990678817033768,
0.005931523162871599,
0.009956748224794865,
0.003653588006272912,
0.013963495381176472,
-0.023246411234140396,
-0.0025591873563826084,
0.039335500448942184,
0.00394024234265089,
0.003193734912201762,
0.0025175607297569513,
0.042323000729084015,
-0.02874726429581642,
-0.0013857026351615787,
0.0072305225767195225,
0.009176074527204037,
-0.0368964783847332,
-0.021710703149437904,
0.0014438661746680737,
0.00793522410094738,
-0.0018987267976626754,
-0.0189751535654068,
0.014828677289187908,
0.010832630097866058,
0.018328344449400902,
-0.009753277525305748,
-0.01435296144336462,
0.022218821570277214,
-0.01755046658217907,
0.007218980696052313,
0.03310895711183548,
0.018443992361426353,
0.030388126149773598,
0.030858932062983513,
0.02231873758137226,
0.013453502207994461,
-0.012723044492304325,
0.018657619133591652,
-0.017635628581047058,
0.020830418914556503,
0.025625349953770638,
-0.00165359431412071,
0.015023836866021156,
-0.014187964610755444,
0.013692568987607956,
-0.02049819566309452,
0.03357652202248573,
-0.022374790161848068,
-0.02169736474752426,
0.006819171831011772,
-0.005168302450329065,
0.025468874722719193,
-0.023438291624188423,
-0.01915263757109642,
-0.03773907572031021,
0.05829472839832306,
-0.004052416421473026,
-0.001814784831367433,
-0.03321421518921852,
0.016621103510260582,
-0.010669189505279064,
-0.005087961908429861,
-0.01699976623058319,
0.02792583778500557,
0.031193524599075317,
-0.010566815733909607,
-0.0192628912627697,
0.035652391612529755,
-0.031583987176418304,
-0.0026016279589384794,
-0.017804551869630814,
-0.010335749946534634,
-0.008211988024413586,
0.00504472479224205,
-0.012496178038418293,
-0.011015458963811398,
-0.0035170945338904858,
-0.014278811402618885,
0.010887977667152882,
-0.0005933322827331722,
-0.04440402239561081,
-0.025766046717762947,
-0.027571769431233406,
-0.018700800836086273,
0.002403644612058997,
0.032757341861724854,
0.016691308468580246,
-0.019187048077583313,
-0.004537359345704317,
-0.013844568282365799,
0.00853723380714655,
0.01279466599225998,
-0.021507060155272484,
0.0023050159215927124,
-0.025801848620176315,
-0.025124628096818924,
0.012306280434131622,
0.008544948883354664,
-0.02308627963066101,
-0.019323254004120827,
0.00892307423055172,
-0.00761374831199646,
-0.039204444736242294,
0.022383134812116623,
-0.0028779113199561834,
-0.01991131529211998,
-0.031335700303316116,
-0.001439309911802411,
0.004642048384994268,
-0.012036950327455997,
-0.005981213878840208,
0.022049596533179283,
-0.00330811133608222,
0.011913657188415527,
0.02260560542345047,
0.0015742962714284658,
0.07099835574626923,
-0.021494748070836067,
0.008586659096181393,
-0.025462398305535316,
0.0017375412862747908,
-0.01816869154572487,
0.014915412291884422,
-0.012807318940758705,
0.005977940745651722,
-0.01466290932148695,
0.015415304340422153,
-0.020154785364866257,
-0.012203783728182316,
0.006966419517993927,
-0.012051752768456936,
0.016540508717298508,
-0.005606263410300016,
-0.02136365883052349,
-0.01869993843138218,
0.0166420117020607,
-0.002468850463628769,
0.00717733521014452,
0.029128767549991608,
-0.05294791981577873,
0.032092493027448654,
-0.03707867115736008,
0.04807790741324425,
-0.011157161556184292,
-0.009321855381131172,
0.013350343331694603,
-0.01942283846437931,
0.013873026706278324,
-0.008785842917859554,
-0.002403780585154891,
0.03783575817942619,
0.0004280372231733054,
0.008769075386226177,
0.004460868425667286,
0.007739324122667313,
-0.018285034224390984,
-0.01991851069033146,
-0.0071875061839818954,
0.010416421107947826,
0.006844188552349806,
-0.03509403020143509,
-0.02472815290093422,
-0.0009774761274456978,
-0.010556585155427456,
-0.0019472766434773803,
-0.012039288878440857,
-0.008207525126636028,
-0.010821337811648846,
0.017713867127895355,
0.018250443041324615,
0.011632272973656654,
0.013303604908287525,
0.018050389364361763,
-0.012735414318740368,
-0.013768980279564857,
-0.023914575576782227,
-0.009914576075971127,
-0.009654275141656399,
-0.020693214610219002,
-0.015521848574280739,
0.011539322324097157,
-0.008303388953208923,
0.006327548995614052,
0.037935394793748856,
-0.014144175685942173,
0.0027265348471701145,
-0.02145085483789444,
-0.0058171688579022884,
0.04604525491595268,
-0.009468279778957367,
-0.03461320698261261,
0.001713701756671071,
-0.03663722798228264,
-0.006376202218234539,
-0.011545938439667225,
-0.01984935812652111,
0.00020258156291674823,
0.003946783021092415,
-0.02141439914703369,
-0.053959332406520844,
-0.0031326061580330133,
-0.04110235720872879,
-0.05202391371130943,
-0.07419002801179886,
-0.017874617129564285,
-0.0025619312655180693,
-0.01045894157141447,
0.011808285489678383,
-0.015443092212080956,
-0.0257961917668581,
-0.015673570334911346,
-0.04824225977063179,
-0.007048624102026224,
-0.0310620479285717,
0.029403764754533768,
0.03347233310341835,
-0.0012503147590905428,
0.013086956925690174,
0.03233062103390694,
-0.023184657096862793,
0.002372301183640957,
-0.03697817027568817,
0.019581874832510948,
0.007552087772637606,
0.008665998466312885,
-0.019286323338747025,
-0.0024049284402281046,
-0.010636013001203537,
-0.07993805408477783,
-0.0009488517534919083,
0.028325475752353668,
-0.013933670707046986,
-0.009867507964372635,
-0.05031388998031616,
-0.004785110242664814,
-0.019398385658860207,
-0.013697154819965363,
-0.016998806968331337,
-0.003354544984176755,
-0.010793915018439293,
-0.028819140046834946,
-0.008469434455037117,
-0.027821900323033333,
-0.0007731445948593318,
0.02441234141588211,
0.023802660405635834,
0.01706969551742077,
0.03745429217815399,
-0.010996575467288494,
0.02454773709177971,
-0.004699214827269316,
0.023605700582265854,
-0.006255429238080978,
-0.029997793957591057,
-0.03286515548825264,
0.011847819201648235,
0.012782301753759384,
-0.01701897755265236,
-0.010201663710176945,
-0.008035737089812756,
-0.01783270388841629,
0.029059097170829773,
-0.016232136636972427,
-0.020648982375860214,
0.024222223088145256,
-0.02443794161081314,
0.018277928233146667,
0.0028762698639184237,
0.008396748453378677,
0.011412045918405056,
0.02843204140663147,
-0.01795387454330921,
0.0042898752726614475,
0.01371107529848814,
0.0033065166790038347,
-0.013787509873509407,
0.035481423139572144,
-0.01974467560648918,
0.00975039042532444,
-0.02711469866335392,
0.011997697874903679,
0.01181866880506277,
-0.010586179792881012,
0.004123130347579718,
-0.02097715064883232,
-0.010124685242772102,
0.01854536682367325,
0.014760177582502365,
0.0031473261769860983,
-0.006307803560048342,
0.03939352184534073,
0.07070815563201904,
0.00014953721256460994,
0.00026468580472283065,
-0.004534908104687929,
-0.009793604724109173,
0.0029556327499449253,
0.008040118962526321,
-0.007891001179814339,
-0.04852638766169548,
-0.012836976908147335,
0.011783504858613014,
-0.0031005279161036015,
-0.018420414999127388,
0.008770939894020557,
-0.009894528426229954,
-0.05108271539211273,
0.0046149264089763165,
0.004877183586359024,
-0.03863738104701042,
0.01679687760770321,
-0.0029339701868593693,
0.0026782816275954247,
-0.025769095867872238,
0.0010397892910987139,
-0.010569844394922256,
-0.013084285892546177,
-0.019030436873435974,
0.019630074501037598,
-0.0007423869683407247,
-0.004898574203252792,
-0.01476694643497467,
0.014945168979465961,
-0.006039262283593416,
-0.02789751999080181,
-0.0003081809263676405,
0.008531295694410801,
0.004261457361280918,
0.028275571763515472,
-0.034876491874456406,
0.010007216595113277,
-0.004414710216224194,
-0.015400680713355541,
-0.00657234713435173,
0.0016288183396682143,
-0.003309683408588171,
-0.0032870210707187653,
0.014170628972351551,
0.03158781677484512,
-0.03764817491173744,
0.016925456002354622,
-0.0021711376029998064,
-0.003182072890922427,
0.02623758092522621,
-0.010084856301546097,
0.007627073209732771,
-0.008192023262381554,
-0.02787713147699833,
0.01612834632396698,
-0.014782469719648361,
-0.011368101462721825,
-0.015087487176060677,
-0.019884629175066948,
-0.0030323006212711334,
-0.02417615056037903,
0.019408542662858963,
-0.028781244531273842,
0.032833632081747055,
-0.020913179963827133,
-0.045014139264822006,
0.00692311255261302,
-0.01456498447805643,
0.016852986067533493,
0.008575295098125935,
-0.014771871268749237,
0.020465509966015816,
0.030707387253642082,
0.015589438378810883,
-0.0042434087954461575,
0.025563152506947517,
0.009837271645665169,
-0.010328398086130619,
-0.004470963962376118,
-0.032941896468400955,
0.04740235581994057,
0.013995431363582611,
-0.017963528633117676,
-0.010326768271625042,
-0.01420964952558279,
-0.0016828076913952827,
0.0006475008558481932,
-0.02537987381219864,
0.00039048222242854536,
-0.00007448183168889955,
0.021366214379668236,
0.0002709869004320353,
0.03563547506928444,
0.019088832661509514,
0.0008647848735563457,
0.011339088901877403,
-0.0029161882121115923,
-0.012239193543791771,
-0.020669961348176003,
-0.00037565772072412074,
-0.011625382117927074,
0.0180988609790802,
0.0012306232238188386,
0.012726863846182823,
0.0049611362628638744,
-0.001358606037683785,
0.028153765946626663,
0.02444530837237835,
-0.05348961427807808,
0.032810017466545105,
-0.027278903871774673,
0.016775717958807945,
0.005970665719360113,
0.0008583686430938542,
0.028616029769182205,
-0.006989393383264542,
-0.017838329076766968,
-0.008538743481040001,
-0.012756375595927238,
0.013612779788672924,
0.011215155012905598,
-0.017723534256219864,
-0.017220616340637207,
-0.009879319928586483,
-0.016253413632512093,
0.006585915572941303,
0.007484107278287411,
0.019104788079857826,
-0.015879763290286064,
-0.01341695711016655,
0.0076807281002402306,
-0.04796455428004265,
-0.018220048397779465,
0.004524536430835724,
0.003152735298499465,
-0.01750551536679268,
-0.0013040531193837523,
-0.0016531413421034813,
-0.026383712887763977,
0.009795276448130608,
0.02702069655060768,
0.010277212597429752,
-0.03281247243285179,
-0.023562686517834663,
0.030123278498649597,
0.013437020592391491,
0.023385807871818542,
-0.01660834439098835,
-0.016547486186027527,
0.002474961569532752,
-0.008425258100032806,
0.010320442728698254,
0.012224945239722729,
0.003532659960910678,
-0.033105574548244476,
-0.006181271281093359,
-0.01962030492722988,
0.019739199429750443,
-0.006752675399184227,
0.006820935755968094,
-0.0033121926244348288,
-0.011083436198532581,
0.03980438411235809,
0.008891453966498375,
0.033364515751600266,
0.003175920806825161,
-0.010188348591327667,
0.0013667963212355971,
-0.013240396045148373,
0.03352481499314308,
0.03447866067290306,
-0.014497758820652962,
-0.0007905935635790229,
0.016068825498223305,
0.01365851704031229,
0.048212241381406784,
0.01633196696639061,
0.03616199642419815,
-0.005512915086001158,
0.005974436178803444,
-0.012549127452075481,
0.0033621734473854303,
0.007257699500769377,
-0.018379267305135727,
0.013337591663002968,
0.00756984855979681,
0.007743573281913996,
-0.04036088287830353,
0.0199629757553339,
-0.014278894290328026,
0.00309290224686265,
-0.011116006411612034,
0.004639954771846533,
0.00543818948790431,
-0.015768125653266907,
-0.0038921767845749855,
0.017296552658081055,
-0.006082393694669008,
-0.005282746162265539
] | [
0.10604677349328995,
0.08721661567687988,
0.15145792067050934,
-0.13322781026363373,
-0.05152101814746857,
0.3978945314884186,
0.3832045793533325,
-0.16029809415340424,
-0.5197251439094543,
-0.494030624628067,
0.0963156521320343,
-0.30407291650772095,
-0.5045408010482788,
0.228328138589859,
0.6060470342636108,
0.7082735300064087,
0.0005222430336289108,
0.44848859310150146,
-0.3215125501155853,
-0.6133387088775635,
-0.35036930441856384,
-0.7955441474914551,
0.44694826006889343,
0.3160732388496399,
-0.012889813631772995,
-0.27113309502601624,
0.2849954664707184,
-0.284569650888443,
0.288984477519989,
-0.33703309297561646,
0.08806687593460083,
0.7107545733451843,
0.3356291651725769,
-0.34254246950149536,
-0.1747540831565857,
0.10727519541978836,
-0.21543817222118378,
0.09327247738838196,
-0.08594164252281189,
-0.20312771201133728,
-0.13238926231861115,
-0.24761486053466797,
-0.11231715232133865,
0.11961580067873001,
0.23090116679668427,
-0.8275577425956726,
-1.093987226486206,
0.6347428560256958,
0.05963831767439842,
0.15641970932483673,
0.36047959327697754,
-0.13158361613750458,
0.5382834672927856,
0.0073523083701729774,
-0.16454839706420898,
0.22880548238754272,
-0.9490558505058289,
-0.205299973487854,
0.2230960577726364,
-0.2004084587097168,
0.39293408393859863,
-0.25044381618499756,
-0.07827737927436829,
0.16790369153022766,
-0.4176453649997711,
0.4225640296936035,
0.055326394736766815,
0.42909136414527893,
0.09348146617412567,
-0.07493314892053604,
0.44962799549102783,
-0.2138325721025467,
0.02795265056192875,
-0.24141886830329895,
0.10422386974096298,
-0.1254301369190216,
-0.24256151914596558,
-0.49116018414497375,
0.17241916060447693,
0.3643171787261963,
0.0318792462348938,
-0.2501474618911743,
0.3056337237358093,
0.029645822942256927,
0.4486522674560547,
0.24700385332107544,
0.010471013374626637,
0.5662126541137695,
-0.12439035624265671,
0.23629549145698547,
-0.02850860357284546,
0.2555948793888092,
0.7537587881088257,
0.19877958297729492,
0.08697305619716644,
0.5699618458747864,
-0.23340600728988647,
-0.039172664284706116,
0.31359562277793884,
-0.13124734163284302,
-0.28586673736572266,
0.008032920770347118,
-0.2925011217594147,
-0.22264981269836426,
-0.19068267941474915,
-0.06960491836071014,
-0.23489901423454285,
-0.7382802367210388,
-0.33674222230911255,
-0.10632164776325226,
-0.5526754260063171,
-0.18837696313858032,
-0.2483866810798645,
-0.36245131492614746,
-0.4723835587501526,
0.1677689105272293,
0.2815383970737457,
-0.4609217047691345,
0.3045888841152191,
0.0717935562133789,
-0.36925414204597473,
0.8978888988494873,
-0.38224855065345764,
0.42371150851249695,
-0.26822495460510254,
0.06993008404970169,
0.25270283222198486,
-0.2806529700756073,
0.1577993482351303,
0.188861683011055,
-0.12916363775730133,
0.7018761038780212,
-0.45889365673065186,
0.06535247713327408,
0.2949044704437256,
-0.07072919607162476,
-0.3006603717803955,
0.32859566807746887,
0.08368333429098129,
-0.10998830199241638,
-0.48455676436424255,
-0.9540176391601562,
-0.1462886482477188,
0.32904374599456787,
-0.03020070493221283,
0.15710298717021942,
-0.7135381698608398,
0.24881108105182648,
-0.31081563234329224,
-0.13937382400035858,
-0.2076495736837387,
-0.1868368536233902,
-0.4646020829677582,
-0.022622549906373024,
-0.04555663838982582,
0.40498262643814087,
-0.21151132881641388,
-0.2514336407184601,
0.14095842838287354,
-0.07916900515556335,
0.8640910387039185,
0.33733469247817993,
-0.26782429218292236,
-0.01490540336817503,
0.4891935884952545,
0.04826836287975311,
-0.34311068058013916,
0.15053929388523102,
-0.31339728832244873,
-0.121869295835495,
-0.24687208235263824,
-0.12037649750709534,
0.051124561578035355,
-0.5923388004302979,
0.11828571557998657,
-0.02789483219385147,
0.19431336224079132,
0.3016246557235718,
0.25668078660964966,
0.13189175724983215,
-0.6323409676551819,
-0.046393174678087234,
-0.2170237898826599,
-0.4790959358215332,
0.7100402116775513,
0.28683215379714966,
0.19019316136837006,
-0.031219689175486565,
0.3096621036529541,
0.37619897723197937,
0.07755345106124878,
-0.2618563175201416,
0.460591197013855,
-0.42970994114875793,
1.308937668800354,
-0.3604668080806732,
-0.005125491879880428,
1.2520232200622559,
0.6521488428115845,
0.012923256494104862,
-0.011456127278506756,
0.16606847941875458,
0.9122214913368225,
-0.05806860327720642,
-0.6486333012580872,
0.3033114969730377,
-0.24153275787830353,
-0.2115979641675949,
-0.18821731209754944,
0.35058897733688354,
0.3871344327926636,
-0.23456060886383057,
0.02652335911989212,
-0.21870344877243042,
0.34360355138778687,
0.10333583503961563,
-0.1377316266298294,
-0.34129786491394043,
0.022027280181646347,
-0.16901572048664093,
0.6711608171463013,
-0.8345216512680054,
0.5806061625480652,
0.7345404028892517,
-0.2922302782535553,
0.6560143232345581,
0.440390408039093,
-0.08335525542497635,
0.8120566606521606,
-1.0597831010818481,
0.2352997362613678,
-0.6151239275932312,
0.3554006814956665,
-0.31297606229782104,
-0.3635365962982178,
0.27162203192710876,
0.017496367916464806,
-0.186044842004776,
-0.053412437438964844,
0.1875377595424652,
0.30483683943748474,
0.742917537689209,
-0.36111733317375183,
0.4254501461982727,
0.13753430545330048,
-0.2904139757156372,
0.09943641722202301,
0.3055075407028198,
-0.707476794719696,
-0.054224807769060135,
0.4950140714645386,
0.6238287091255188,
0.2134009152650833,
-0.44254568219184875,
0.22448177635669708,
-0.2019481211900711,
0.28859540820121765,
-0.5058017373085022,
0.04531221091747284,
-0.35473909974098206,
0.05920514836907387,
0.19699639081954956,
0.27111271023750305,
0.44247743487358093,
0.33676454424858093,
-0.6570026874542236,
-0.971005380153656,
-0.5687690377235413,
0.5519475340843201,
0.31203120946884155,
1.1571420431137085,
0.20014794170856476,
-0.34777316451072693,
-0.0642971470952034,
0.32933175563812256,
-0.45992228388786316,
0.05214281380176544,
0.8202042579650879,
-0.7436626553535461,
-0.14944860339164734,
-0.22631479799747467,
0.20198144018650055,
0.654570996761322,
-0.21153254806995392,
-0.2677547037601471,
-0.034584444016218185,
-0.315889447927475,
-0.21383394300937653,
-0.8327932357788086,
-0.4088588058948517,
0.17621943354606628,
0.19625486433506012,
0.029679032042622566,
0.03855409100651741,
0.08350715786218643,
0.037207990884780884,
-0.15634389221668243,
1.0143471956253052,
0.8123194575309753,
0.059594228863716125,
-0.14219342172145844,
0.23244276642799377,
-0.1576690822839737,
-0.13072165846824646,
-0.10821995139122009,
-0.05562543869018555,
-0.3384360373020172,
0.25363460183143616,
-6.005180835723877,
-0.16127833724021912,
-0.46136996150016785,
-0.10453427582979202,
-0.3538062274456024,
-0.02441995032131672,
1.0986545085906982,
-0.19403085112571716,
0.0891294777393341,
0.49199968576431274,
0.6958988904953003,
0.7260530591011047,
0.24831029772758484,
-0.24944515526294708,
-0.36410072445869446,
0.19048887491226196,
-0.175550639629364,
-0.23547188937664032,
0.33631807565689087,
0.14374196529388428,
0.04786042496562004,
0.1935611516237259,
-0.3415784239768982,
0.3178735673427582,
0.1677633374929428,
-0.15182359516620636,
-0.7835350632667542,
0.22103507816791534,
-0.23442423343658447,
-0.12916922569274902,
0.12712816894054413,
-0.571651041507721,
-0.0655297040939331,
0.11818612366914749,
-0.16288241744041443,
-0.0784490704536438,
0.11615906655788422,
-0.09175363928079605,
-0.4593713879585266,
-0.4565291404724121,
-0.1421550065279007,
-0.28302353620529175,
-0.2895580530166626,
-0.3904625475406647,
-0.29414063692092896,
-0.20995350182056427,
0.1615801304578781,
0.17735032737255096,
0.23522786796092987,
0.6238203048706055,
0.06012381240725517,
-0.07519028335809708,
0.2590443789958954,
0.8707784414291382,
0.466098427772522,
-0.029431477189064026,
-0.2461061030626297,
0.5774879455566406,
-0.5319674611091614,
0.08506616204977036,
-0.16403187811374664,
0.03229909390211105,
0.05595432594418526,
-0.4472905993461609,
0.3933820426464081,
0.1836448311805725,
-0.2779276371002197,
-0.3709503710269928,
0.27979588508605957,
0.010837903246283531,
-0.21576987206935883,
0.19215121865272522,
0.3960825204849243,
-0.70528644323349,
0.2061125636100769,
-0.6690844893455505,
0.3746882975101471,
0.15175418555736542,
-0.2283245325088501,
-0.563274621963501,
-0.4485171437263489,
-0.3089199662208557,
-0.00847096461802721,
0.041771575808525085,
0.42490217089653015,
-0.18954797089099884,
0.15748350322246552,
-0.22816772758960724,
0.11642768234014511,
0.36766982078552246,
-0.01383216492831707,
-0.16785570979118347,
-0.05375949293375015,
0.5265361666679382,
0.17096292972564697,
0.6435571312904358,
0.38453295826911926,
0.46455273032188416,
0.47325780987739563,
-0.04430308938026428,
0.9058517217636108,
-0.21645015478134155,
-0.5373223423957825,
-0.9058305025100708,
-0.1621728092432022,
0.2952896058559418,
0.11188657581806183,
-0.06861726194620132,
0.9382650852203369,
-0.663732647895813,
0.40242263674736023,
-0.3959308862686157,
-0.016216373071074486,
-0.24995338916778564,
0.7040844559669495,
-0.19275331497192383,
0.23158979415893555,
0.07664009928703308,
0.4576178193092346,
-0.1416568011045456,
0.34025251865386963,
0.4098619520664215,
-0.7242659330368042,
0.6807798147201538,
0.012671182863414288,
0.10807668417692184,
-0.008203422650694847,
0.4000749886035919,
-0.8039379119873047,
-0.24227745831012726,
-0.14092954993247986,
0.14243438839912415,
0.09833987802267075,
0.05133197456598282,
0.414906769990921,
-0.41596779227256775,
-0.1848812848329544,
0.23561939597129822,
0.41323333978652954,
-0.1704668551683426,
0.1957864612340927,
-0.1113034337759018,
-0.33959025144577026,
0.38374555110931396,
-0.5875146985054016,
-0.05152767151594162,
-0.24800735712051392,
-0.13990181684494019,
-0.5271602869033813,
-0.30813732743263245,
0.2341149002313614,
-0.474381685256958,
0.2614996135234833,
0.35297125577926636,
-0.8915682435035706,
0.2919880747795105,
0.42169317603111267,
0.17386211454868317,
0.056418146938085556,
-0.5702269077301025,
0.4460318684577942,
0.04177579656243324,
-1.2449913024902344,
-0.22439372539520264,
0.09007908403873444,
-0.2843471169471741,
0.08888036757707596,
-0.5031488537788391,
0.11722219735383987,
0.43248385190963745,
-0.20705032348632812,
-0.44754764437675476,
0.09648127108812332,
-0.0733981654047966,
0.3709867596626282,
0.16971854865550995,
-0.4689420163631439,
-0.21625816822052002,
0.20887166261672974,
0.3513142466545105,
0.2623579502105713,
-0.26421236991882324,
-0.320236474275589,
0.4750458598136902,
0.248539537191391,
0.7384465932846069,
0.06081562116742134,
-0.3282065689563751,
-0.2514321804046631,
0.11137742549180984,
0.17511659860610962,
0.2186562865972519,
0.026189163327217102,
-0.01166282407939434,
-0.16482408344745636,
0.027849603444337845,
-0.1734115034341812,
0.034619953483343124,
-0.006914418190717697,
0.022595273330807686,
0.10691385716199875,
0.500187337398529,
-0.17818938195705414,
0.193159282207489,
0.248452827334404,
0.07183913141489029,
-0.3876226842403412,
0.039652734994888306,
-0.14209426939487457,
-0.5483956336975098,
-0.034339237958192825,
-0.5949320793151855,
-0.17372502386569977,
0.5612422823905945,
0.07710929214954376,
0.560330331325531,
0.019941678270697594,
-0.4161834418773651,
0.08276030421257019,
0.30581238865852356,
-0.18596681952476501,
0.24599507451057434,
-0.09614527225494385,
-0.3803735077381134,
-0.3386627733707428,
0.5913763642311096,
0.37781527638435364,
-0.8692513704299927,
0.2068047672510147,
0.3032674193382263,
-0.2655618488788605,
-0.127767413854599,
0.2400924265384674,
0.3190314769744873,
-0.40793612599372864,
-0.31467685103416443,
-0.09824150800704956,
-0.12365157902240753,
-0.0010364301269873977,
0.08581539243459702,
0.02966253086924553,
0.48973575234413147,
-0.4100239872932434,
-0.4790838956832886,
-0.03067840076982975,
0.147124245762825,
0.25010815262794495,
-0.6087266802787781,
-0.32199808955192566,
0.11205841600894928,
0.13294820487499237,
-0.3182549476623535,
0.23142226040363312,
-0.012520900927484035,
0.7213461399078369,
0.25296223163604736,
0.26291152834892273,
-0.4164714515209198,
-0.028169304132461548,
-0.029898568987846375,
-0.12454736977815628,
0.041163939982652664,
-0.2329685389995575,
-0.09233538806438446,
-0.2905932068824768,
0.1167059987783432,
-0.14482517540454865,
-0.52367103099823,
0.01587148755788803,
0.0999385342001915,
-0.05149771645665169,
-0.16325785219669342,
0.6249520182609558,
0.48909229040145874,
0.1554017812013626,
0.40485796332359314,
-0.38734155893325806,
0.04464629292488098,
-0.538582980632782,
0.3882063329219818,
-0.29364722967147827,
-0.596792995929718,
0.059780094772577286,
0.027491768822073936,
0.068534255027771,
-0.36569178104400635,
-0.13692131638526917,
-0.2800562083721161,
-0.2563348114490509,
-0.2603833079338074,
-0.021132946014404297,
0.227082297205925,
-0.7723310589790344,
-0.32960042357444763,
0.20778943598270416,
0.31243982911109924,
0.07224424928426743,
0.5159795880317688,
-0.3100912570953369,
-0.3279269337654114,
-0.6707665920257568,
0.7106634378433228,
0.22415199875831604,
-0.24482014775276184,
-0.09845132380723953,
0.01618846505880356,
0.1281256079673767,
0.019911089912056923,
-0.021248871460556984,
0.24238352477550507,
0.5375630855560303,
-0.1052306517958641,
0.3127864599227905,
0.19361178576946259,
-0.23178982734680176,
0.3488166630268097,
-0.4425962269306183,
-0.22916680574417114,
0.25193721055984497,
-0.17740999162197113,
0.47700774669647217,
0.7379696369171143,
0.5140084028244019,
0.18292665481567383,
-0.6161205172538757,
0.6760435104370117,
-0.207257479429245,
0.21621578931808472,
0.04491593688726425,
0.8873288631439209,
0.49336883425712585,
-0.00801665335893631,
-0.553799033164978,
0.5368285775184631,
0.35098907351493835,
0.3690768778324127,
-0.013971621170639992,
-0.778691828250885,
-0.3340734541416168,
-0.34484991431236267,
0.9930127263069153,
0.37291401624679565,
0.16769398748874664,
-0.006016298197209835,
-0.1461208462715149,
0.3609875440597534,
-0.12889787554740906,
0.05571312829852104,
-0.15227724611759186,
-0.3241833448410034,
0.4691605269908905,
-0.25746607780456543,
-0.4001331627368927,
-0.010768132284283638,
-0.48761019110679626,
0.31279486417770386,
0.11185388267040253,
-0.4429183006286621,
-0.46207085251808167,
0.2054465115070343,
-0.06390684098005295,
-0.18927839398384094,
0.25764909386634827,
0.44898685812950134,
0.08487306535243988,
-0.5988147258758545,
0.3282763361930847,
0.1417647749185562,
-0.207355797290802,
-0.4054114818572998,
0.05882453918457031,
-0.5381706357002258,
-0.38523542881011963,
0.22630350291728973,
0.4468090236186981,
-0.05151456221938133,
-0.3826369643211365,
-0.010911411605775356,
-0.20995312929153442,
0.3381323516368866,
-0.6303374767303467,
0.060693591833114624,
-0.4920431077480316,
-0.5020527243614197,
0.032627612352371216,
-0.006882868241518736,
-0.3416028320789337,
0.21677449345588684,
0.3709893524646759,
0.2498253732919693,
0.012342788279056549,
-0.20888714492321014,
0.04987998306751251,
0.06771707534790039,
0.3334091305732727,
-0.4015452563762665,
-0.08534219115972519,
0.38209912180900574,
-0.062338344752788544,
0.3985239565372467,
-0.10657300055027008,
-0.09170577675104141,
-0.47062811255455017,
0.16933369636535645,
-0.3909773528575897,
0.4018925726413727,
-0.5120480060577393,
0.07373188436031342,
-0.6409677863121033,
-0.04611094668507576,
0.5484442710876465,
0.4391816258430481,
-0.5502579212188721,
0.2742830216884613,
0.1461564004421234,
0.14299985766410828,
0.6105319857597351,
-0.7993295192718506,
-0.5088510513305664,
-0.6749995946884155,
-0.4744972586631775,
-0.4810104966163635,
0.976386547088623,
-0.09640467911958694,
-0.2715272903442383,
0.31932762265205383,
0.2752116918563843,
0.45523467659950256,
0.2272242307662964,
0.5769252777099609,
-0.5752328634262085,
0.10942751914262772,
-0.5339351296424866,
0.1677345186471939,
-0.6231010556221008,
0.029668642207980156,
-0.03874269872903824,
0.015659533441066742,
0.21395407617092133,
0.10319101065397263,
0.24012722074985504,
-0.8530789017677307,
0.06236262246966362,
-0.17585952579975128,
0.190163716673851,
0.36948561668395996,
-0.06085988134145737,
-0.41087496280670166,
-0.4947952628135681,
0.11869248002767563,
-0.19173972308635712,
-0.16980625689029694,
-0.35651689767837524,
0.1515331119298935,
-0.16728593409061432,
0.11287117004394531,
0.015225696377456188,
-0.39140987396240234,
0.07917129248380661,
-0.036727212369441986
] |
In April 2009, a new influenza A (H1N1 2009) virus emerged that rapidly spread around the world. While current variants of this virus have caused widespread disease, particularly in vulnerable groups, there remains the possibility that future variants may cause increased virulence, drug resistance or vaccine escape. Early detection of these virus variants may offer the chance for increased containment and potentially prevention of the virus spread. We have developed and field-tested a resequencing kit that is capable of interrogating all eight segments of the 2009 influenza A(H1N1) virus genome and its variants, with added focus on critical regions such as drug-binding sites, structural components and mutation hotspots. The accompanying base-calling software (EvolSTAR) introduces novel methods that utilize neighbourhood hybridization intensity profiles and substitution bias of probes on the microarray for mutation confirmation and recovery of ambiguous base queries. Our results demonstrate that EvolSTAR is highly accurate and has a much improved call rate. The high throughput and short turn-around time from sample to sequence and analysis results (30 h for 24 samples) makes this kit an efficient large-scale evolutionary biosurveillance tool. | [
-0.030680611729621887,
0.02184212952852249,
-0.0033268711995333433,
0.012088671326637268,
0.008417901583015919,
0.0018586516380310059,
0.008091872557997704,
0.011959142982959747,
-0.020358065143227577,
-0.026786258444190025,
0.0208062082529068,
0.020686594769358635,
-0.001321056392043829,
-0.012787622399628162,
0.01664888486266136,
-0.004266103729605675,
0.002128402004018426,
0.03548336401581764,
0.02015005424618721,
-0.004794752690941095,
-0.02832220122218132,
-0.001492256298661232,
0.011980172246694565,
0.0038435542955994606,
0.019975770264863968,
0.020105168223381042,
-0.025709321722388268,
0.0014277547597885132,
-0.05265969783067703,
-0.036039307713508606,
0.015176206827163696,
0.008587270975112915,
0.006177895702421665,
0.018130868673324585,
-0.002526538446545601,
0.01404392346739769,
-0.0021637440659105778,
0.02281685546040535,
-0.006835240870714188,
-0.001425202121026814,
0.043971382081508636,
-0.02246553637087345,
0.009028652682900429,
-0.0039710067212581635,
-0.011447181925177574,
0.03116602636873722,
-0.005449545569717884,
-0.005996977910399437,
-0.012851353734731674,
0.007420765236020088,
-0.005214642733335495,
-0.00845410954207182,
-0.008816035464406013,
0.05405016615986824,
-0.008158251643180847,
-0.004526371136307716,
0.023105869069695473,
0.01662190817296505,
-0.015588777139782906,
0.028287842869758606,
0.004576502367854118,
-0.019735192880034447,
0.015650136396288872,
0.009437834843993187,
-0.0219747144728899,
-0.06643862277269363,
-0.006501713767647743,
-0.005905152298510075,
0.021268168464303017,
0.0009178800974041224,
0.010052752681076527,
0.007346182130277157,
-0.017454097047448158,
-0.011724963784217834,
-0.033203721046447754,
0.004269733093678951,
-0.0021724861580878496,
0.03323440998792648,
0.00042999954894185066,
0.024054214358329773,
0.001537838950753212,
-0.012599032372236252,
0.022314198315143585,
0.0400080606341362,
-0.008147546090185642,
0.011436139233410358,
-0.028551042079925537,
-0.01338074542582035,
-0.0122873205691576,
-0.002067850437015295,
0.01539686881005764,
-0.03229838237166405,
-0.08065861463546753,
-0.027450665831565857,
-0.005089507903903723,
-0.051066603511571884,
0.005791804753243923,
-0.012958455830812454,
-0.005374903790652752,
-0.05606738477945328,
0.012581268325448036,
0.00848502665758133,
0.009257299825549126,
-0.003855654038488865,
0.007232613395899534,
0.009823540225625038,
0.014582589268684387,
-0.00226694718003273,
-0.005937312263995409,
0.00018100527813658118,
-0.004839968867599964,
-0.0063956682570278645,
0.02925105392932892,
0.02195674367249012,
-0.011953962966799736,
0.0006913787219673395,
0.002797398716211319,
0.027079150080680847,
0.007512710988521576,
0.0007645376026630402,
-0.011414676904678345,
-0.012826470658183098,
0.02093958668410778,
0.01134321466088295,
-0.0021630229894071817,
-0.019103828817605972,
-0.0070429579354822636,
-0.026812341064214706,
0.01062321849167347,
0.0009002862498164177,
-0.009688189253211021,
-0.012530755251646042,
-0.03756602853536606,
-0.005661592818796635,
-0.020598631352186203,
0.007372426800429821,
-0.020855121314525604,
-0.007907973602414131,
-0.026930440217256546,
-0.01046193391084671,
-0.018501633778214455,
0.0106285959482193,
-0.0031515280716121197,
0.035567816346883774,
0.028471559286117554,
0.0022567526903003454,
-0.0013593615731224418,
0.016075285151600838,
0.036615148186683655,
0.007087142672389746,
-0.011607334017753601,
-0.011097155511379242,
-0.028086530044674873,
-0.0028087268583476543,
-0.007783065550029278,
0.025718264281749725,
0.0005476251826621592,
-0.031623996794223785,
-0.026833102107048035,
0.026343779638409615,
0.019366351887583733,
-0.006169924512505531,
-0.025958139449357986,
0.009350670501589775,
0.022196587175130844,
-0.003056917805224657,
0.0488562174141407,
-0.01195579580962658,
-0.0023738062009215355,
0.006204082630574703,
-0.009965742938220501,
0.015524733811616898,
-0.0074529340490698814,
0.020484209060668945,
0.001338684931397438,
-0.0071679772809147835,
0.007331707514822483,
0.008138910867273808,
0.009075390174984932,
0.06627319008111954,
0.0017687473446130753,
0.009993357583880424,
0.008496950380504131,
0.03549759462475777,
0.013410682789981365,
-0.007404732052236795,
0.021322090178728104,
-0.021700510755181313,
-0.02638290263712406,
-0.012845818884670734,
-0.03944212570786476,
0.0068792924284935,
-0.016295839101076126,
-0.035796888172626495,
-0.003910779021680355,
0.0036199840251356363,
0.04022081196308136,
-0.0005234342534095049,
0.015466248616576195,
0.008171407505869865,
-0.0062372153624892235,
0.027606625109910965,
0.0487992987036705,
0.0017776081804186106,
-0.058847904205322266,
0.004692452494055033,
-0.01387768890708685,
0.01366371475160122,
-0.006567693315446377,
-0.03443289175629616,
0.02379833534359932,
-0.01246095634996891,
0.00409696577116847,
-0.02249271795153618,
-0.021115925163030624,
-0.0054932753555476665,
0.01053547952324152,
0.021278250962495804,
-0.006043615750968456,
-0.018977517262101173,
0.004397585056722164,
0.006177043076604605,
-0.034458234906196594,
0.012780874967575073,
0.013702401891350746,
0.013499759137630463,
0.02308553457260132,
0.0171709805727005,
-0.014740388840436935,
0.008194422349333763,
-0.028353463858366013,
-0.0038530193269252777,
-0.00992295891046524,
-0.006658116355538368,
0.023130811750888824,
0.010673577897250652,
0.013554612174630165,
-0.037061359733343124,
0.0010528538841754198,
-0.02143329568207264,
-0.00026255950797349215,
-0.015927186235785484,
0.004643572028726339,
-0.0007937245536595583,
0.015313979238271713,
0.002671333495527506,
0.024679850786924362,
0.010160316713154316,
-0.005128019489347935,
-0.028951292857527733,
0.012832194566726685,
-0.007323769852519035,
0.02436152845621109,
-0.014272421598434448,
0.022696129977703094,
0.011086651124060154,
0.02404240146279335,
0.027920592576265335,
0.025819703936576843,
-0.0005991705693304539,
0.008224503137171268,
0.006149165332317352,
0.01616084948182106,
-0.02172861248254776,
0.0017514154314994812,
0.0459112748503685,
0.01199452392756939,
0.01788691058754921,
0.04486628621816635,
-0.003791383933275938,
0.009062745608389378,
-0.010188396088778973,
0.006207597907632589,
-0.08139974623918533,
-0.016892194747924805,
-0.0032210610806941986,
-0.037154823541641235,
0.019348803907632828,
-0.013288013637065887,
0.00010031182318925858,
0.0025874399580061436,
-0.016491077840328217,
0.061381787061691284,
0.02019663155078888,
0.0030716820620000362,
-0.0013614422641694546,
-0.0018064631149172783,
0.013435864821076393,
0.0011759032495319843,
0.01024416834115982,
0.013768814504146576,
-0.012267394922673702,
-0.008757906965911388,
-0.024535084143280983,
-0.017734253779053688,
0.035064697265625,
-0.011283069849014282,
-0.012463768012821674,
-0.01674313098192215,
0.007295688614249229,
0.013003828004002571,
0.02031540870666504,
0.007514549419283867,
0.014646733179688454,
-0.027657076716423035,
0.01844235509634018,
-0.004247501492500305,
0.025048058480024338,
-0.009617496281862259,
0.003499632468447089,
-0.021324560046195984,
-0.003503474872559309,
-0.005421824753284454,
-0.00932745449244976,
0.008950228802859783,
0.012379326857626438,
0.021016379818320274,
0.013855380937457085,
-0.014185161329805851,
0.013556057587265968,
0.04168017953634262,
0.025012072175741196,
0.007485632784664631,
-0.012448755092918873,
-0.011004777625203133,
0.021040480583906174,
0.019601615145802498,
-0.0053364066407084465,
-0.014534518122673035,
-0.023503046482801437,
0.012390517629683018,
-0.0036701764911413193,
0.0037856230046600103,
-0.029567565768957138,
0.032165803015232086,
0.0031327283941209316,
-0.020890042185783386,
-0.03567562997341156,
0.009711497463285923,
0.001758108614012599,
0.00754587072879076,
-0.001411042409017682,
0.030561156570911407,
-0.026105646044015884,
-0.0003663483075797558,
0.00343906506896019,
-0.021157827228307724,
-0.009973324835300446,
0.00023363321088254452,
-0.01760777086019516,
-0.018883459270000458,
0.005344646517187357,
-0.0033613054547458887,
-0.009139575995504856,
0.013102836906909943,
-0.013898716308176517,
0.0003961566835641861,
-0.001817065174691379,
0.03794163838028908,
0.012468012049794197,
-0.0076207322999835014,
0.019024182111024857,
-0.021590182557702065,
0.010132637806236744,
0.013413514010608196,
-0.009550780989229679,
0.011614874005317688,
-0.021106930449604988,
-0.013022150844335556,
-0.024061519652605057,
-0.004280246794223785,
0.004484236240386963,
0.010121087543666363,
0.009565792046487331,
-0.02069173939526081,
0.006520564667880535,
-0.00814006943255663,
-0.004424569196999073,
0.0171003770083189,
-0.0003850790672004223,
-0.02626810222864151,
-0.021621743217110634,
-0.014166856184601784,
0.009753754362463951,
0.02127229981124401,
-0.001090817037038505,
-0.027413852512836456,
0.015462061390280724,
0.004757814109325409,
0.026495691388845444,
-0.033082522451877594,
0.07107459008693695,
-0.0076231868006289005,
0.019683001562952995,
-0.011853779666125774,
0.04879829287528992,
-0.01683780364692211,
0.010712549090385437,
-0.011300955899059772,
0.01079835556447506,
-0.00046712998300790787,
0.0149112269282341,
-0.050124794244766235,
-0.01705617643892765,
-0.025939563289284706,
0.034194160252809525,
-0.0021021352149546146,
0.013486117124557495,
-0.03773260861635208,
0.02705908939242363,
-0.014481788501143456,
-0.013084827922284603,
-0.0322929210960865,
0.0011153609957545996,
0.00919237919151783,
0.022648368030786514,
-0.012551628053188324,
0.033439505845308304,
-0.014246968552470207,
0.012128655798733234,
0.006247124634683132,
0.004302958957850933,
-0.0015236835461109877,
-0.005181857384741306,
0.004360168240964413,
0.014491874724626541,
-0.0006194720044732094,
0.0010837223380804062,
-0.018645018339157104,
-0.007274649105966091,
-0.026972031220793724,
0.011940451338887215,
-0.017029497772455215,
0.005881520453840494,
0.019953183829784393,
-0.006434244103729725,
0.035707153379917145,
0.005021229386329651,
-0.008895572274923325,
-0.014080182649195194,
0.0039402153342962265,
-0.0035217173863202333,
-0.002754815388470888,
0.008848238736391068,
-0.0018534152768552303,
0.021339155733585358,
0.020737048238515854,
-0.0021653331350535154,
0.002023350913077593,
0.021496282890439034,
-0.01110975444316864,
-0.03644758462905884,
-0.033794552087783813,
-0.0023055989295244217,
-0.016156118363142014,
-0.0012738872319459915,
0.0003042651806026697,
-0.0034068413078784943,
0.01260463334619999,
-0.046201691031455994,
-0.005931082647293806,
0.006257114466279745,
0.005224387627094984,
0.004444729071110487,
-0.01906670071184635,
-0.06202821433544159,
-0.021642114967107773,
-0.02197534590959549,
0.00016247620806097984,
-0.02219058945775032,
0.016886763274669647,
0.01594286412000656,
-0.024914449080824852,
0.004282996524125338,
-0.0087311752140522,
-0.006014897022396326,
-0.0014601163566112518,
-0.03212215378880501,
-0.07383694499731064,
-0.02119174599647522,
0.006039634812623262,
-0.00818144902586937,
0.034126635640859604,
-0.004014104604721069,
-0.027973230928182602,
0.009935440495610237,
-0.023652570322155952,
0.0058793313801288605,
-0.01028461940586567,
-0.014533384703099728,
0.035819727927446365,
0.0177302248775959,
0.020281098783016205,
0.0301080159842968,
-0.032691240310668945,
-0.0021293489262461662,
0.0022784320171922445,
0.0007154392078518867,
0.015092818066477776,
0.005068770609796047,
-0.04007934033870697,
-0.010676676407456398,
-0.0015596081502735615,
-0.07983599603176117,
-0.01830417290329933,
0.019197607412934303,
-0.005698399152606726,
0.0014457735233008862,
-0.03204188868403435,
0.016460027545690536,
-0.028146035969257355,
-0.008176479488611221,
-0.017137575894594193,
-0.0023993453942239285,
0.010937711223959923,
-0.008541809394955635,
-0.004519650712609291,
0.026110485196113586,
-0.01033798698335886,
0.012213064357638359,
0.014505406841635704,
0.016383150592446327,
0.02755538374185562,
0.03601490706205368,
0.031651683151721954,
-0.007887749001383781,
-0.001418327447026968,
-0.021342124789953232,
-0.03391582518815994,
-0.0028245854191482067,
0.010470632463693619,
0.02314111962914467,
0.01355573907494545,
-0.015231075696647167,
-0.00344280619174242,
0.0018342938274145126,
0.0026309362147003412,
0.05033784732222557,
-0.0018451260402798653,
0.021161604672670364,
-0.012363115325570107,
0.054434165358543396,
0.018077079206705093,
-0.007621889468282461,
0.008853249251842499,
0.0018335338681936264,
0.01832692325115204,
-0.005135043524205685,
0.009136950597167015,
0.013969546183943748,
-0.0064554885029792786,
0.019302848726511,
0.004109303932636976,
0.000861957436427474,
-0.03604587912559509,
-0.005486038513481617,
-0.002784362528473139,
-0.0005888901650905609,
-0.016469493508338928,
0.0010962262749671936,
0.02108744904398918,
0.01161323394626379,
0.011753171682357788,
0.009713024832308292,
0.0032912446185946465,
0.008929458446800709,
0.07081606984138489,
-0.01889505423605442,
0.021326661109924316,
-0.020336363464593887,
-0.004115077666938305,
-0.0027118385769426823,
-0.009583967737853527,
0.037077657878398895,
-0.033160723745822906,
-0.024287261068820953,
0.024106744676828384,
-0.007134193554520607,
-0.016454583033919334,
0.0026148846372962,
0.013167678378522396,
0.011365181766450405,
0.011031758040189743,
-0.03990262746810913,
-0.046400830149650574,
-0.010505546815693378,
0.0015815566293895245,
-0.004132894799113274,
0.011465541087090969,
-0.024666091427206993,
0.01954576000571251,
-0.0010386743815615773,
-0.05741516500711441,
-0.012069124728441238,
-0.03403039649128914,
0.004149685148149729,
-0.003497630823403597,
0.020916607230901718,
-0.0013290983624756336,
-0.021911367774009705,
0.03502539545297623,
-0.008068898692727089,
0.023279283195734024,
0.016439950093626976,
0.015810344368219376,
0.04147697612643242,
-0.01289121713489294,
0.00446708407253027,
-0.0067953988909721375,
0.020788785070180893,
0.021904554218053818,
-0.03862224519252777,
0.007307255640625954,
0.03700084984302521,
-0.00745238596573472,
0.023458758369088173,
0.005446131341159344,
0.012281430885195732,
0.012538076378405094,
-0.010748347267508507,
0.004021929111331701,
0.033478379249572754,
-0.0004929793067276478,
0.0220341756939888,
0.01224250067025423,
0.004193090833723545,
-0.00015237834304571152,
-0.02172836661338806,
-0.0027725892141461372,
-0.023175738751888275,
0.0006482433527708054,
0.014632300473749638,
0.0066934870555996895,
-0.023775380104780197,
-0.016394082456827164,
0.0032076744828373194,
-0.005515594035387039,
0.020407341420650482,
0.010422611609101295,
0.011206451803445816,
0.04412807524204254,
0.021624233573675156,
0.03484901785850525,
-0.006009109318256378,
0.013868235051631927,
0.01076875813305378,
-0.011776384897530079,
-0.01771390251815319,
0.013200744986534119,
0.016374830156564713,
-0.013820668682456017,
-0.005962604656815529,
0.009315816685557365,
-0.027107566595077515,
-0.0036446196027100086,
0.006720658391714096,
-0.007280727848410606,
-0.0026642947923392057,
0.0070031192153692245,
0.009625541046261787,
0.018397130072116852,
0.03599349781870842,
0.006591285578906536,
0.01060083694756031,
0.03134148567914963,
0.000060970429331064224,
-0.019040895625948906,
-0.012034007348120213,
-0.0009614699520170689,
-0.025587718933820724,
0.02209467440843582,
0.0024264734238386154,
0.040382660925388336,
0.007405651733279228,
0.00427097687497735,
0.013566207140684128,
-0.004345831926912069,
0.021267039701342583,
0.004075623583048582,
0.005154839716851711,
-0.017358694225549698,
0.005614235065877438,
-0.010336708277463913,
0.017991799861192703,
-0.012970534153282642,
-0.012237051501870155,
-0.031733281910419464,
-0.017404917627573013,
-0.008451951667666435,
0.018714571371674538,
-0.017226925119757652,
0.01256624050438404,
-0.007801972329616547,
-0.02666613459587097,
-0.02656468003988266,
0.019998865202069283,
0.0003027034690603614,
-0.006732258480042219,
-0.015333641320466995,
0.02163710817694664,
0.02495839074254036,
-0.014939523302018642,
0.016545742750167847,
-0.006153799593448639,
0.00023341237101703882,
-0.017862875014543533,
-0.0007883859798312187,
0.011119893752038479,
0.009041305631399155,
-0.024079572409391403,
0.013109888881444931,
0.021369781345129013,
-0.01027301698923111,
-0.01614871621131897,
0.007408211939036846,
-0.011079013347625732,
0.02430311217904091,
-0.0032852867152541876,
0.004101750906556845,
-0.0076645370572805405,
0.012591767124831676,
0.006072563584893942,
0.014122105203568935,
-0.056259479373693466,
-0.003475592937320471,
0.011772497557103634,
0.00016427412629127502,
0.009331277571618557,
0.013773662969470024,
0.010136803612112999,
-0.00015545682981610298,
0.016744334250688553,
0.05978716164827347,
0.019641922786831856,
-0.004533042199909687,
-0.0026403251104056835,
-0.0248846635222435,
-0.028826314955949783,
-0.010308659635484219,
0.005572206806391478,
0.012229704298079014,
-0.02638798952102661,
-0.011349909007549286,
0.01103595644235611,
-0.015356142073869705,
0.003809744492173195,
0.007017705589532852,
0.002541934372857213,
0.023856723681092262,
-0.013471283949911594,
-0.009986136108636856,
0.0036547090858221054,
-0.028317373245954514,
0.03337768837809563,
0.035495173186063766,
0.0006211046129465103,
-0.009106181561946869,
-0.005163433030247688,
-0.0009543946944177151,
0.013549008406698704,
-0.00039918581023812294,
-0.015703517943620682,
-0.025405585765838623,
-0.010378513485193253,
0.006510146893560886,
0.033322773873806,
0.022014934569597244,
0.020527027547359467
] | [
0.1768535077571869,
-0.014425590634346008,
0.13340167701244354,
-0.27982887625694275,
-0.42978399991989136,
-0.27634280920028687,
0.564746081829071,
0.2698598802089691,
-0.4835754334926605,
-0.4556727707386017,
0.06414985656738281,
-0.15827172994613647,
-0.8763366341590881,
0.6994417309761047,
0.17768487334251404,
0.18057599663734436,
0.4151763916015625,
0.18582893908023834,
-0.3081889748573303,
-0.060468051582574844,
-0.3742324113845825,
-0.5594261884689331,
-0.03688099980354309,
-0.11742676049470901,
-0.19169394671916962,
-0.2785906493663788,
0.3822280764579773,
0.12859533727169037,
0.6675819158554077,
-0.2733007073402405,
0.22899752855300903,
0.505643904209137,
0.1507369726896286,
-0.2505386173725128,
-0.5440002083778381,
-0.0780632495880127,
-0.4698130190372467,
0.21109305322170258,
-0.17453353106975555,
-0.5365674495697021,
-0.3195701837539673,
-0.028031596913933754,
-0.3449099659919739,
0.553204357624054,
0.03831662982702255,
-0.4621265232563019,
-1.5223891735076904,
0.2741554081439972,
-0.1382835954427719,
0.23507723212242126,
0.14244168996810913,
-0.05414107069373131,
-0.20027197897434235,
0.16333073377609253,
-0.2927038073539734,
0.4104782044887543,
-0.5662176609039307,
-0.12054392695426941,
-0.06608324497938156,
-0.03703739866614342,
0.11549079418182373,
-0.7402032017707825,
0.021244967356324196,
0.4083610475063324,
-0.4387120008468628,
0.7901700139045715,
0.51287841796875,
0.4423745572566986,
0.12452949583530426,
-0.5543144941329956,
-0.1315256506204605,
-0.6331897974014282,
-0.32851192355155945,
-0.21633148193359375,
0.15777170658111572,
-0.39193177223205566,
0.015067069791257381,
-0.6334991455078125,
0.39616450667381287,
0.531050443649292,
-0.028270341455936432,
0.2308163344860077,
0.28849324584007263,
-0.43913164734840393,
0.381192147731781,
0.25365352630615234,
0.1049533411860466,
0.7346464991569519,
-0.2828677296638489,
0.1137511357665062,
0.08401063829660416,
-0.2631511390209198,
0.7339891195297241,
0.1655030995607376,
0.14635701477527618,
0.328957200050354,
-0.13348864018917084,
0.0317407064139843,
0.2849210500717163,
-0.46515896916389465,
-0.17933616042137146,
0.05035838857293129,
-0.1606852412223816,
-0.37644895911216736,
-0.3766215741634369,
-0.19732481241226196,
-0.08589901030063629,
-1.0435954332351685,
0.10174140334129333,
-0.18049266934394836,
-0.09243763238191605,
0.20595981180667877,
-0.23809954524040222,
-0.19900596141815186,
-0.34866756200790405,
0.726568877696991,
0.6804689168930054,
-0.6555542945861816,
0.2729562520980835,
-0.08288862556219101,
-0.30206137895584106,
0.8928701281547546,
-0.08543985337018967,
0.4159370958805084,
-0.07285767048597336,
0.04926847666501999,
0.21638932824134827,
0.019501101225614548,
-0.3373425304889679,
0.432718962430954,
-0.21027715504169464,
0.936829149723053,
-0.05402412638068199,
-0.1911744922399521,
0.5234894752502441,
-0.009966389276087284,
-0.22081834077835083,
0.3531988263130188,
-0.08981651067733765,
-0.28933724761009216,
-0.22725249826908112,
-0.50937420129776,
-0.41317611932754517,
0.18464083969593048,
0.1751520335674286,
0.3826780617237091,
-0.3269016146659851,
-0.1837739199399948,
-0.3216491937637329,
-0.6370255947113037,
-0.108241967856884,
-0.669448733329773,
-0.22460365295410156,
0.2598053216934204,
0.2404063642024994,
0.5475898385047913,
-0.5599386096000671,
0.022113805636763573,
0.42497047781944275,
0.17501886188983917,
0.4870593845844269,
0.33148473501205444,
-0.22910724580287933,
-0.08858606964349747,
0.07993465662002563,
-0.01778857223689556,
0.08767851442098618,
0.772870659828186,
0.014967255294322968,
-0.46125176548957825,
-0.3472183048725128,
-0.26015040278434753,
0.03105938620865345,
-0.3129488229751587,
-0.10738663375377655,
-0.11550432443618774,
0.8802675604820251,
-0.15504132211208344,
0.3559815287590027,
0.4587950110435486,
-0.5683824419975281,
-0.12707142531871796,
0.33969688415527344,
-0.31435513496398926,
0.39659613370895386,
0.587352991104126,
0.2819516360759735,
0.29626360535621643,
0.36521846055984497,
0.47436249256134033,
-0.4159749448299408,
-0.1610308140516281,
0.0826299712061882,
-0.47155892848968506,
1.0647915601730347,
0.04853465408086777,
0.034714147448539734,
1.7763220071792603,
0.023275453597307205,
0.6697251200675964,
0.13955296576023102,
0.20203933119773865,
0.6419558525085449,
-0.27106842398643494,
-0.49415653944015503,
-0.32802650332450867,
-0.028440462425351143,
-0.3142269551753998,
-0.16402100026607513,
0.3028969466686249,
0.4063122570514679,
0.13316509127616882,
-0.036373354494571686,
-0.131172776222229,
0.07504597306251526,
0.6459973454475403,
0.10703086107969284,
-0.24378417432308197,
-0.3699946403503418,
-0.38031429052352905,
0.4401600658893585,
-0.5365617275238037,
-0.053639691323041916,
0.3386848568916321,
0.29461780190467834,
0.8153587579727173,
0.4382226765155792,
-0.2699567675590515,
0.7366918325424194,
-0.721930980682373,
-0.07436544448137283,
0.00350388465449214,
0.45093482732772827,
-0.6753188967704773,
-0.061976682394742966,
0.1856619119644165,
0.24482184648513794,
-0.21311123669147491,
-0.17701636254787445,
0.031243830919265747,
0.9751417636871338,
0.08384767919778824,
-0.3860774040222168,
0.3130960464477539,
0.27369147539138794,
-0.05612899363040924,
0.25080883502960205,
0.08114389330148697,
-0.5527961254119873,
-0.23709337413311005,
0.32084712386131287,
0.583537220954895,
0.4901279807090759,
-0.11320198327302933,
0.15505781769752502,
0.044798023998737335,
-0.09897217154502869,
-0.26291927695274353,
0.49112948775291443,
0.32091549038887024,
0.08984727412462234,
-0.2198312133550644,
0.23054848611354828,
0.40426284074783325,
0.18271872401237488,
-0.7803021669387817,
-0.4808379113674164,
-0.6119850873947144,
0.37300315499305725,
0.27606943249702454,
0.9787822961807251,
0.053147945553064346,
-0.34098541736602783,
0.028358325362205505,
0.48994943499565125,
-0.7973468899726868,
0.0260818712413311,
0.8149722814559937,
-0.6031906008720398,
-0.29298368096351624,
-0.21105554699897766,
0.577321469783783,
0.6829288005828857,
-0.645901620388031,
-0.31369927525520325,
-0.5110720992088318,
-0.21138855814933777,
-0.5223032236099243,
-0.7834975123405457,
0.361882746219635,
0.2702321708202362,
-0.013189218007028103,
-0.5486868619918823,
0.01766291819512844,
-0.2573847472667694,
-0.18424944579601288,
-0.06294029206037521,
0.33996352553367615,
0.42975324392318726,
0.4557502269744873,
-0.39596229791641235,
0.3005047142505646,
-0.2574024200439453,
-0.48365625739097595,
-0.06685946881771088,
-0.01452635321766138,
-0.12323123216629028,
-0.37949711084365845,
-5.937678813934326,
-0.04773475602269173,
0.18665359914302826,
-0.4601200520992279,
-0.633866012096405,
0.49872109293937683,
0.7704671025276184,
0.28258877992630005,
0.2191363126039505,
0.06633968651294708,
0.73275226354599,
0.34465381503105164,
0.1031583771109581,
-0.18510960042476654,
-0.3516068458557129,
0.051772866398096085,
0.13772401213645935,
0.1845516711473465,
0.2922877073287964,
0.05879587680101395,
0.0020485203713178635,
-0.2758462727069855,
-0.010527454316616058,
0.04255915805697441,
0.1446743607521057,
-0.012389670126140118,
-0.8969739079475403,
0.36262136697769165,
-0.22928228974342346,
0.3332275152206421,
0.2228090614080429,
-0.3766302764415741,
-0.07017078250646591,
-0.19717957079410553,
-0.5817208290100098,
0.01248480100184679,
0.0074157207272946835,
-0.509716808795929,
-0.3054300844669342,
-0.5404969453811646,
0.3151988089084625,
-0.05518113821744919,
-0.05712838098406792,
-0.5892840027809143,
0.09927237778902054,
-0.18244877457618713,
0.20082660019397736,
0.33081796765327454,
-0.19919969141483307,
0.4765722155570984,
0.07931225001811981,
-0.06817071884870529,
0.25606009364128113,
0.3149663209915161,
0.30283525586128235,
-0.08550549298524857,
0.02739507146179676,
0.08547709137201309,
-0.22908829152584076,
-0.09151085466146469,
0.08095879852771759,
-0.22531026601791382,
0.09740661829710007,
-0.6076689958572388,
0.32320064306259155,
0.07495682686567307,
-0.6587013006210327,
-0.41996198892593384,
0.5304204225540161,
0.2383570373058319,
-0.4798032343387604,
0.370726615190506,
0.2998671233654022,
-0.6996343731880188,
0.07110706716775894,
-0.6742241382598877,
-0.11307952553033829,
0.032378122210502625,
-0.184185191988945,
-0.4325920641422272,
-0.32131427526474,
-0.7272494435310364,
-0.31674787402153015,
-0.47173821926116943,
0.4390954077243805,
-0.598827600479126,
0.0387384407222271,
-0.1726345270872116,
-0.19422392547130585,
-0.018371259793639183,
0.6161812543869019,
-0.4484628438949585,
0.05564766004681587,
0.36146852374076843,
0.2663015127182007,
0.556904673576355,
0.18133512139320374,
0.4016408622264862,
0.2907189726829529,
0.1375458538532257,
0.3835274577140808,
-0.38277849555015564,
-0.2861432135105133,
-0.5634464025497437,
0.09986048936843872,
-0.03181272745132446,
-0.4417976438999176,
-0.07663335651159286,
1.0486644506454468,
-0.22011509537696838,
-0.21526798605918884,
-0.36039215326309204,
-0.34133318066596985,
0.07980351895093918,
0.31493330001831055,
-0.2533257007598877,
0.3075920641422272,
0.22385047376155853,
0.5471549034118652,
-0.427276074886322,
0.5075302124023438,
0.649272084236145,
-0.38173404335975647,
0.4968665838241577,
0.4028235971927643,
0.004434812813997269,
-0.11522161960601807,
0.4162544310092926,
-0.44842374324798584,
-0.5544781684875488,
0.4529809355735779,
0.13529890775680542,
-0.22592277824878693,
-0.4008617103099823,
0.739485502243042,
0.1346484273672104,
-0.5764232873916626,
-0.4648352861404419,
0.0027113149408251047,
-0.11012105643749237,
-0.4936895966529846,
-0.038493894040584564,
-0.044924795627593994,
0.1029694601893425,
-0.12364190071821213,
0.06379812955856323,
0.4142862558364868,
-0.28921574354171753,
-0.3101899027824402,
-0.10197500884532928,
0.01101192831993103,
-0.23841701447963715,
0.06024997681379318,
0.3448835015296936,
-1.030298113822937,
0.5275058150291443,
1.2784955501556396,
0.3135441839694977,
-0.28331536054611206,
-0.45795029401779175,
0.1575859785079956,
0.03689318150281906,
-0.43942365050315857,
0.06951673328876495,
0.22312964498996735,
-0.030503401532769203,
0.6048500537872314,
0.030274393036961555,
0.03457481414079666,
0.20932725071907043,
-0.1430562436580658,
-0.29613664746284485,
-0.413954496383667,
0.04395171254873276,
0.07541001588106155,
0.40577664971351624,
-0.1748710423707962,
0.0632442906498909,
0.17556031048297882,
0.47931110858917236,
0.17849919199943542,
-0.3910227417945862,
-0.4724336266517639,
0.26343750953674316,
0.2487092763185501,
-0.10332046449184418,
-0.05139303579926491,
-0.3191010057926178,
-0.3374737799167633,
-0.1810859590768814,
0.3857792019844055,
0.4445340633392334,
-0.23461925983428955,
0.08032424747943878,
-0.2274160087108612,
-0.4975200295448303,
-0.42556941509246826,
-0.2519250214099884,
0.10786954313516617,
-0.39980843663215637,
0.2575114965438843,
0.40709590911865234,
-0.12542209029197693,
-0.014871322549879551,
0.40769267082214355,
-0.5162580609321594,
-0.254524827003479,
-0.410885214805603,
0.2779931426048279,
-0.18003502488136292,
0.31272590160369873,
-0.3702250123023987,
-0.10358879715204239,
0.7742460370063782,
0.09642527252435684,
0.2964823544025421,
-0.12701331079006195,
-0.3037661015987396,
-0.019047824665904045,
0.2931813895702362,
-0.2875663638114929,
-0.01244637742638588,
-0.16121594607830048,
-0.257781058549881,
-0.5730828642845154,
0.7038290500640869,
0.5455609560012817,
-0.5765116810798645,
-0.16261602938175201,
-0.429188996553421,
0.11353033035993576,
-0.1339360624551773,
0.371913343667984,
0.5792264342308044,
-0.39683663845062256,
-0.2706747055053711,
0.2733127474784851,
-0.37289950251579285,
0.2578147053718567,
0.7053778171539307,
0.2987396717071533,
0.1764880269765854,
-0.3193444609642029,
-0.4457114636898041,
-0.4140182137489319,
-0.24004842340946198,
0.011329953558743,
-0.4133598804473877,
-0.027531679719686508,
-0.0938640758395195,
-0.5260379314422607,
-0.2801084518432617,
0.13770878314971924,
0.05069044977426529,
0.6723370552062988,
-0.024407699704170227,
-0.18374167382717133,
-0.5002297759056091,
-0.17810039222240448,
-0.7732018828392029,
-0.07041481882333755,
0.07283595204353333,
-0.5635071396827698,
0.05698570981621742,
0.37415626645088196,
0.10545815527439117,
-0.7241742610931396,
-0.3996203541755676,
-0.2695894241333008,
-0.17647616565227509,
-0.23945553600788116,
0.09012071043252945,
0.2569112777709961,
0.600490927696228,
0.2737840712070465,
0.27658572793006897,
-0.24115756154060364,
-0.0283400509506464,
-0.2746600806713104,
0.4326961934566498,
-0.1660207360982895,
-0.24797052145004272,
0.46235063672065735,
-0.08204422891139984,
0.1105632334947586,
-0.23575423657894135,
0.06310011446475983,
-0.648054838180542,
0.28225815296173096,
-0.6808421015739441,
-0.19197024405002594,
0.5053136348724365,
-0.46678876876831055,
-0.2980714440345764,
0.04929757118225098,
0.15773291885852814,
-0.05491582304239273,
0.4650677442550659,
-0.2887147068977356,
-0.3286393880844116,
-0.2959155738353729,
0.7242332100868225,
0.6514004468917847,
-0.18867968022823334,
0.02507169544696808,
0.1781986653804779,
0.24078810214996338,
0.7611379027366638,
0.08220545202493668,
0.33006665110588074,
0.36588922142982483,
0.47869884967803955,
0.22759567201137543,
0.3335167169570923,
-0.734192430973053,
0.2916571795940399,
-0.29497870802879333,
-0.4572075605392456,
0.16267767548561096,
-0.4407951235771179,
0.36693546175956726,
0.7968840003013611,
0.14215360581874847,
-0.29324615001678467,
-1.0530489683151245,
0.7004216909408569,
-0.3743518590927124,
0.31714868545532227,
-0.19395609200000763,
0.5149424076080322,
0.5886740684509277,
0.26934656500816345,
-0.4416607618331909,
0.10585419088602066,
0.1613115668296814,
-0.09627967327833176,
0.07425057888031006,
-0.0029268781654536724,
-0.19210252165794373,
0.39741358160972595,
1.0243161916732788,
-0.03976006060838699,
-0.12573696672916412,
0.15082138776779175,
0.02535555697977543,
0.14002154767513275,
0.004935421049594879,
0.17812740802764893,
0.6894042491912842,
0.0410115122795105,
0.3311910629272461,
0.2381005883216858,
0.2357623428106308,
0.25519540905952454,
-0.26938295364379883,
-0.49811533093452454,
0.21438325941562653,
-0.3733844757080078,
-0.3059912919998169,
-0.16457808017730713,
0.2449650913476944,
0.19355055689811707,
0.28839564323425293,
0.5629170536994934,
0.09282876551151276,
0.15622864663600922,
0.42829155921936035,
0.1894899308681488,
0.02285214513540268,
-0.2409127652645111,
0.08380433917045593,
-0.5360395908355713,
-0.1892627626657486,
0.34479156136512756,
0.08652549237012863,
0.046736862510442734,
0.032400500029325485,
-0.05913427099585533,
-0.09192202240228653,
0.3618534505367279,
-0.46424153447151184,
-0.3581424057483673,
-0.14396068453788757,
-0.42559686303138733,
-0.016234535723924637,
-0.19066095352172852,
-0.23924759030342102,
0.19090627133846283,
0.0179560799151659,
-0.24005988240242004,
0.07541078329086304,
-0.8170719146728516,
0.028881248086690903,
0.19128373265266418,
0.003260689554736018,
-0.11015725135803223,
0.19801722466945648,
0.7182274460792542,
-0.1323845535516739,
0.5470490455627441,
-0.11766946315765381,
-0.09785598516464233,
-0.442291796207428,
0.6193337440490723,
-0.5322369337081909,
0.6516718864440918,
-0.3794613778591156,
-0.04680999368429184,
-0.45744064450263977,
0.2767222225666046,
0.5589398145675659,
0.5286401510238647,
-0.018490055575966835,
0.14504554867744446,
-0.4201417565345764,
-0.10773859173059464,
0.2785859704017639,
-0.39965391159057617,
-0.39258506894111633,
-0.7374398112297058,
-0.3781059980392456,
-0.41740936040878296,
0.009057496674358845,
-0.1497531533241272,
-0.12424922734498978,
-0.1077844500541687,
0.3902880549430847,
0.3423440158367157,
-0.3504190444946289,
0.5656870007514954,
-0.007203354500234127,
0.36624133586883545,
-0.2350071668624878,
-0.18179674446582794,
-1.0236316919326782,
-0.2772678732872009,
0.4202069938182831,
0.3001694977283478,
0.11257021874189377,
0.28775155544281006,
-0.04526256024837494,
-0.3607918620109558,
0.29914188385009766,
0.18801172077655792,
-0.0376233346760273,
0.10075031220912933,
0.02102859877049923,
-0.07853161543607712,
-0.7001034021377563,
0.1794288158416748,
0.2888941466808319,
0.4870605766773224,
-0.3891715407371521,
-0.21906812489032745,
0.04686746746301651,
0.3818923830986023,
0.24309737980365753,
-0.3819020092487335,
0.19549398124217987,
-0.09923412650823593
] |
In the wake of the SARS epidemic and the H1N1 pandemic, the PLoS Medicine editors ask whether journal publishing is an efficient enough mechanism for information sharing. | [
-0.00986999087035656,
0.013644316233694553,
0.005751878954470158,
0.06157219782471657,
-0.010016226209700108,
0.009277477860450745,
0.02021893486380577,
0.03781187906861305,
-0.035368721932172775,
-0.11079753935337067,
-0.011671396903693676,
0.033076412975788116,
-0.013507329858839512,
-0.008589006960391998,
0.07443837821483612,
-0.07782381027936935,
0.012690539471805096,
-0.0028895323630422354,
0.0407455749809742,
-0.024871090427041054,
0.009353344328701496,
0.02500452846288681,
0.018818648532032967,
0.058216020464897156,
-0.025205550715327263,
-0.00821506604552269,
0.022985199466347694,
-0.07084894925355911,
-0.03682650625705719,
0.033147163689136505,
0.07195188850164413,
0.03594651445746422,
0.03781392052769661,
0.032035164535045624,
0.0006435003597289324,
0.006499770563095808,
-0.0021430121269077063,
0.026217021048069,
0.015525240451097488,
-0.005379975773394108,
-0.03549746796488762,
-0.019684338942170143,
0.010525669902563095,
-0.01454858761280775,
-0.01645064912736416,
0.045418642461299896,
-0.01256756391376257,
0.05577651038765907,
-0.012820141389966011,
0.021212410181760788,
-0.006276385858654976,
0.022850951179862022,
0.0004282532609067857,
0.00943700224161148,
-0.013840625062584877,
-0.003988232929259539,
0.031247453764081,
0.060322895646095276,
-0.04201028123497963,
0.05897526070475578,
-0.0022260225377976894,
0.07474319636821747,
-0.006728086620569229,
0.10788961499929428,
-0.005391268525272608,
-0.06309761106967926,
0.02815704420208931,
0.0045449198223650455,
-0.025067506358027458,
0.03187384456396103,
0.0070627606473863125,
0.020838052034378052,
0.033744633197784424,
0.014801373705267906,
-0.016866689547896385,
-0.008165495470166206,
0.03487974405288696,
-0.0019358808640390635,
-0.04818486049771309,
0.014731498435139656,
0.005077327601611614,
0.0031026203650981188,
-0.05967170000076294,
0.06718293577432632,
0.0025690151378512383,
0.03919225558638573,
-0.07026275247335434,
0.04491880163550377,
-0.03469774127006531,
0.009746262803673744,
0.041167356073856354,
-0.05730803683400154,
-0.023627618327736855,
-0.011612179689109325,
-0.08955013006925583,
-0.042112357914447784,
-0.043532393872737885,
0.03181568533182144,
0.03681522235274315,
-0.048043329268693924,
-0.003264931496232748,
0.018134208396077156,
0.05094140022993088,
0.03100324235856533,
0.011165633797645569,
0.002815431449562311,
-0.03835183382034302,
0.08182836323976517,
0.02296108566224575,
0.006175080314278603,
-0.010600588284432888,
0.042966328561306,
-0.003975803032517433,
0.02749130129814148,
-0.021400030702352524,
0.08340416103601456,
-0.002999251475557685,
0.04206959530711174,
0.022141268476843834,
-0.029064079746603966,
0.007274474948644638,
-0.05993291735649109,
0.004804338328540325,
0.07282500714063644,
-0.004211998078972101,
-0.004846051800996065,
0.012788076885044575,
-0.057480793446302414,
-0.03338664770126343,
0.0073915040120482445,
-0.011204972863197327,
-0.02044423669576645,
0.007719611283391714,
0.037879642099142075,
0.038661327213048935,
-0.006890529301017523,
-0.07142408192157745,
0.025233877822756767,
0.0023611667566001415,
-0.02605140581727028,
-0.03592675179243088,
0.01823882944881916,
-0.015565268695354462,
0.04536445811390877,
-0.009963969700038433,
0.022541910409927368,
0.013718798756599426,
0.009355873800814152,
0.014420022256672382,
0.027215776965022087,
0.010111184790730476,
-0.016706222668290138,
-0.0007721919100731611,
-0.015006366185843945,
-0.04669348895549774,
0.06819406151771545,
-0.0008338658954016864,
-0.08549337089061737,
-0.026972850784659386,
0.045131467282772064,
-0.002712271874770522,
-0.01662478968501091,
-0.05102658271789551,
0.018821021541953087,
0.04401872307062149,
-0.03532389923930168,
0.003808162175118923,
-0.021416548639535904,
-0.02424287423491478,
0.003932734951376915,
-0.018611308187246323,
-0.03657323494553566,
0.040589187294244766,
0.019447332248091698,
0.02608056552708149,
-0.03072238527238369,
-0.020281434059143066,
0.007841401733458042,
-0.018760450184345245,
0.06487012654542923,
-0.022358784452080727,
-0.031606730073690414,
0.035575952380895615,
0.0052291215397417545,
0.04957035928964615,
-0.014545008540153503,
-0.006989631801843643,
-0.0011635631090030074,
-0.046911824494600296,
-0.030795861035585403,
-0.017499541863799095,
-0.07948508858680725,
-0.07460489869117737,
-0.015531561337411404,
0.007514334749430418,
0.005819736514240503,
-0.016044681891798973,
-0.01639452949166298,
-0.0022029865067452192,
0.04110774025321007,
0.02035290002822876,
0.06682634353637695,
0.08746867626905441,
0.0015874141827225685,
0.021794119849801064,
0.032013457268476486,
-0.01802423968911171,
-0.05133591592311859,
0.04398967698216438,
0.012825045734643936,
0.024911824613809586,
0.0003137321036774665,
0.004280910361558199,
-0.06212374567985535,
-0.055271636694669724,
-0.017956754192709923,
-0.05362597480416298,
0.011833283118903637,
0.025119151920080185,
-0.038089536130428314,
-0.01750115118920803,
0.004815408494323492,
-0.05488825589418411,
-0.011695416644215584,
0.022097822278738022,
0.0876450315117836,
-0.006944570690393448,
0.0281318761408329,
0.020206063985824585,
-0.00962729100137949,
-0.010589240118861198,
-0.010520891286432743,
-0.018530922010540962,
0.001553666079416871,
0.0501357726752758,
-0.018406463786959648,
0.03488340228796005,
-0.07887888699769974,
0.0044638169929385185,
-0.05022875964641571,
-0.01221409346908331,
-0.060285236686468124,
0.058462951332330704,
0.003813938470557332,
0.044304259121418,
-0.11188066750764847,
0.0604095458984375,
0.022158078849315643,
0.0394538938999176,
0.021550463512539864,
0.008311600424349308,
0.05743756145238876,
0.050343047827482224,
-0.0031418900471180677,
0.0019207206787541509,
-0.03594047576189041,
-0.010547365061938763,
-0.012189104221761227,
0.0379314050078392,
-0.004549757111817598,
0.016837429255247116,
0.0014228002401068807,
-0.040628381073474884,
-0.08643156290054321,
0.017581697553396225,
0.06236797571182251,
-0.00047240921412594616,
-0.016246959567070007,
0.06630045920610428,
0.01888912171125412,
0.007989352568984032,
-0.005381818860769272,
-0.009275664575397968,
-0.0803089439868927,
-0.011047418229281902,
-0.018061278387904167,
0.04861673340201378,
0.03391612321138382,
-0.04821379482746124,
-0.056952331215143204,
-0.002511790255084634,
-0.040871866047382355,
0.03509585186839104,
0.012763208709657192,
0.006556324660778046,
-0.02154630608856678,
-0.01345741469413042,
0.024255994707345963,
-0.022452615201473236,
0.0020339558832347393,
0.0026836928445845842,
-0.04906145855784416,
0.09460771828889847,
-0.010501191020011902,
-0.023137720301747322,
-0.001488153007812798,
-0.024240203201770782,
-0.06704255938529968,
-0.06274816393852234,
0.023036524653434753,
0.00567645812407136,
0.0730392336845398,
0.04062790051102638,
-0.014990459196269512,
-0.08168847858905792,
-0.03342780843377113,
-0.024886423721909523,
0.013430943712592125,
0.03360866755247116,
0.0013434734428301454,
-0.024509979411959648,
-0.004073996562510729,
0.0720507800579071,
0.003805624321103096,
0.0434379018843174,
0.01004986185580492,
-0.0040979827754199505,
0.0048094275407493114,
0.03629409894347191,
0.049428265541791916,
0.023765405640006065,
0.019836854189634323,
0.0271727554500103,
0.02955973707139492,
-0.024088043719530106,
0.014593066647648811,
0.025665558874607086,
-0.0018948436481878161,
-0.014217911288142204,
0.004428609739989042,
-0.0011546006426215172,
-0.018272889778017998,
-0.012581689283251762,
-0.05845634266734123,
0.08195514231920242,
0.03047603741288185,
0.04871755465865135,
-0.04183946177363396,
-0.0017343389336019754,
0.047868289053440094,
-0.02585151232779026,
-0.014683828689157963,
0.021130913868546486,
0.01806320622563362,
0.0019267973257228732,
0.0040960065089166164,
-0.016161305829882622,
-0.034128446131944656,
-0.030720246955752373,
-0.05067725107073784,
-0.0024749916046857834,
0.08640941977500916,
0.03198031708598137,
-0.025422371923923492,
0.02238618955016136,
0.014834590256214142,
-0.00873512215912342,
-0.0294837336987257,
0.011586046777665615,
0.026073146611452103,
-0.03530721738934517,
0.017201771959662437,
-0.034670669585466385,
-0.0061842044815421104,
0.016077548265457153,
-0.0398358516395092,
0.01767072081565857,
0.0008219617884606123,
0.010305077768862247,
0.015716923400759697,
-0.012312712147831917,
0.009757325053215027,
0.01864117570221424,
0.03193609043955803,
0.00008377280028071254,
-0.0348355732858181,
-0.018642835319042206,
-0.005040778778493404,
0.002986003877595067,
-0.012490600347518921,
0.010300874710083008,
-0.03900054097175598,
-0.025806888937950134,
-0.007773886900395155,
0.015800388529896736,
0.01953531801700592,
-0.003225575666874647,
0.03007577359676361,
-0.020572738721966743,
-0.014380482956767082,
0.009913940913975239,
0.06635638326406479,
0.050036244094371796,
0.008943960070610046,
-0.03803110495209694,
0.05036194622516632,
-0.07380398362874985,
-0.010560144670307636,
0.0330248661339283,
0.020774750038981438,
-0.002817881526425481,
0.028514018282294273,
-0.013748894445598125,
0.006489035207778215,
-0.04086355119943619,
-0.00756616797298193,
-0.07057902961969376,
-0.0495796799659729,
-0.005004551261663437,
0.031326811760663986,
-0.018531624227762222,
-0.015405254438519478,
-0.004475196357816458,
0.013966810889542103,
0.01820158213376999,
0.016100309789180756,
0.022213591262698174,
0.05464480444788933,
-0.015629686415195465,
-0.005431529600173235,
-0.00024215609300881624,
0.022649461403489113,
0.01378601510077715,
-0.016760334372520447,
-0.017082910984754562,
0.051875751465559006,
0.0374956913292408,
0.020567525178194046,
0.0023851795122027397,
-0.016053877770900726,
-0.046147558838129044,
-0.009262271225452423,
-0.024879278615117073,
-0.016931656748056412,
0.030462607741355896,
-0.024262454360723495,
0.038180168718099594,
0.04363486170768738,
-0.009890743531286716,
-0.03875907137989998,
0.02203177474439144,
-0.026157408952713013,
0.029619749635457993,
0.029469609260559082,
0.02304612472653389,
0.029125208035111427,
0.008104603737592697,
-0.0729563906788826,
0.01995747908949852,
0.044985827058553696,
-0.01234421320259571,
-0.052475232630968094,
0.014062685891985893,
0.028585268184542656,
0.02540489099919796,
0.0060804602690041065,
-0.0022534430027008057,
-0.021831292659044266,
-0.008031763136386871,
-0.04313090071082115,
0.035029087215662,
0.05479958653450012,
0.035524360835552216,
0.03587464615702629,
0.03855716437101364,
-0.07038262486457825,
-0.05549119785428047,
-0.07223467528820038,
-0.008729344233870506,
0.03744276240468025,
0.01603061705827713,
0.008212042041122913,
0.025673046708106995,
-0.06588171422481537,
-0.06235738471150398,
-0.049564216285943985,
0.008108841255307198,
-0.0437452606856823,
-0.06957148015499115,
-0.08400624990463257,
0.018750101327896118,
-0.0026612163055688143,
-0.012616472318768501,
0.008189582265913486,
-0.02109232358634472,
0.013364589773118496,
-0.04612259566783905,
-0.01892857998609543,
-0.016209231689572334,
0.009762768633663654,
0.040178343653678894,
0.013389544561505318,
0.018521541729569435,
0.013946239836513996,
-0.02043939381837845,
-0.01851055584847927,
-0.00326168374158442,
0.007184888236224651,
-0.03135454282164574,
-0.003920532297343016,
-0.08284380286931992,
-0.02974536083638668,
0.012304496020078659,
-0.0755130797624588,
-0.06263536214828491,
-0.003072253428399563,
-0.052912112325429916,
-0.007134018931537867,
0.017438730224967003,
-0.02358340658247471,
-0.05202915892004967,
-0.036617737263441086,
-0.02678898721933365,
-0.0508214607834816,
-0.0019914384465664625,
0.008066623471677303,
-0.04435955733060837,
0.030584143474698067,
-0.020052488893270493,
0.02552451565861702,
0.0014731448609381914,
0.06148618459701538,
-0.01067089382559061,
0.052786342799663544,
0.08833275735378265,
-0.009113280102610588,
-0.010605856776237488,
-0.03306036815047264,
-0.015541269443929195,
-0.027994569391012192,
0.010004369542002678,
0.04874902591109276,
0.029141269624233246,
-0.03333612158894539,
-0.01890178583562374,
-0.013684635050594807,
-0.029392486438155174,
0.07717468589544296,
-0.005006482824683189,
0.07898122817277908,
0.004549442324787378,
-0.007257107179611921,
-0.01738758571445942,
-0.013452544808387756,
0.034363262355327606,
0.024360094219446182,
-0.0041926028206944466,
0.02353915385901928,
-0.018889909610152245,
0.020467204973101616,
-0.00936680007725954,
0.03330541402101517,
-0.05474212393164635,
0.009492573328316212,
-0.056759025901556015,
-0.02765306457877159,
0.024077624082565308,
-0.05385475978255272,
0.04278140515089035,
-0.012735803611576557,
-0.012655188329517841,
-0.00030532098026014864,
0.033878717571496964,
0.013340403325855732,
0.02164909429848194,
-0.030502619221806526,
0.0687030553817749,
-0.02859606221318245,
0.01516893319785595,
-0.042676083743572235,
-0.023552602156996727,
-0.009673171676695347,
-0.008390255272388458,
0.02332758530974388,
-0.06143707036972046,
0.005971366073936224,
-0.01236976869404316,
-0.04167446866631508,
-0.007245145738124847,
0.008982188999652863,
-0.04324491694569588,
0.05958700180053711,
0.057696402072906494,
-0.006464919075369835,
-0.013953933492302895,
-0.020681265741586685,
-0.01537326630204916,
-0.03987998142838478,
-0.015826484188437462,
-0.004208163358271122,
0.058255989104509354,
-0.014211981557309628,
-0.03953045606613159,
0.09333092719316483,
-0.004666278138756752,
-0.005840729922056198,
-0.0092690484598279,
-0.050469331443309784,
0.0043524038046598434,
0.018413584679365158,
0.024589238688349724,
-0.05813530832529068,
-0.008653535507619381,
0.022678149864077568,
0.009213748387992382,
0.008795562200248241,
0.04661145433783531,
0.0023578954860568047,
0.03404015302658081,
-0.06480463594198227,
0.04723770171403885,
0.04347855597734451,
0.028353452682495117,
0.006135726813226938,
-0.017370758578181267,
-0.014297896064817905,
0.0018475567921996117,
0.012637983076274395,
-0.04774976894259453,
-0.05519789457321167,
-0.03802492842078209,
0.005686549004167318,
-0.05404078587889671,
0.043413106352090836,
0.041695427149534225,
0.01331252045929432,
0.0126163549721241,
-0.037145037204027176,
-0.020691653713583946,
-0.0242955032736063,
-0.004129644483327866,
-0.0014819991774857044,
-0.03778303414583206,
-0.03642434626817703,
-0.026189779862761497,
0.016342924907803535,
-0.007446834817528725,
0.08218807727098465,
0.005243070889264345,
0.01612027734518051,
0.03339258208870888,
0.060195811092853546,
0.04141712933778763,
-0.02264861762523651,
0.0537341870367527,
0.001263172016479075,
-0.03659726306796074,
-0.029470132663846016,
0.05435682460665703,
-0.019309040158987045,
-0.048858948051929474,
0.00009236045298166573,
0.058272507041692734,
-0.017513690516352654,
-0.01909569650888443,
0.017840567976236343,
0.006324936170130968,
0.045575130730867386,
0.006008589174598455,
0.03657058626413345,
0.0176414642482996,
0.04183352366089821,
0.03302498161792755,
0.02236572839319706,
0.03040221333503723,
0.04350748658180237,
-0.005073724314570427,
0.01632804237306118,
-0.011067436076700687,
0.04696297273039818,
-0.016632145270705223,
-0.02676740661263466,
0.01962968334555626,
0.03883097693324089,
0.020435847342014313,
0.000054759093472966924,
-0.017080463469028473,
-0.01192330103367567,
0.048433396965265274,
-0.047833435237407684,
0.0473988875746727,
0.0074220942333340645,
-0.04168083146214485,
-0.00513812992721796,
-0.04331419989466667,
-0.032679472118616104,
-0.01847987063229084,
-0.03501329571008682,
0.06401300430297852,
0.015508798882365227,
-0.021573854610323906,
-0.01492770854383707,
0.0036314381286501884,
0.012621529400348663,
0.005008973181247711,
-0.0013877772726118565,
0.00362565740942955,
-0.054266855120658875,
-0.06890712678432465,
0.043131276965141296,
0.0019384362967684865,
0.006345690693706274,
0.04626726359128952,
-0.011344723403453827,
-0.019631659612059593,
-0.002284961985424161,
0.011092476546764374,
0.002596247708424926,
0.00617308309301734,
0.035249967128038406,
0.014934413135051727,
0.03321294113993645,
-0.0040818252600729465,
-0.014058654196560383,
0.0225474052131176,
0.01790006086230278,
0.029831718653440475,
0.026093224063515663,
0.03229633346199989,
-0.008853803388774395,
-0.007397877983748913,
0.009264381602406502,
-0.0015931418165564537,
0.020923256874084473,
-0.035217199474573135,
0.002811515936627984,
-0.0021173618733882904,
0.047924067825078964,
0.03671871870756149,
-0.028638649731874466,
-0.021746287122368813,
-0.06114663928747177,
-0.06860537081956863,
-0.033272307366132736,
0.01222364604473114,
0.035135965794324875,
-0.011744233779609203,
-0.0503821037709713,
0.007540777791291475,
0.0326683446764946,
0.019401023164391518,
-0.0315462201833725,
-0.010990739800035954,
0.041352976113557816,
-0.007593736983835697,
0.05848461389541626,
0.028293266892433167,
0.027873674407601357,
-0.011001360602676868,
-0.023655591532588005,
-0.013829683884978294,
0.02107246033847332,
-0.02318875677883625,
0.035517096519470215,
0.022971507161855698,
-0.061299826949834824,
-0.0009751472971402109,
0.03435853123664856,
-0.034471094608306885,
-0.023931166157126427,
-0.01016273908317089,
-0.04588887840509415,
0.006637969054281712,
-0.07310789078474045,
0.01957528665661812,
0.0013633737107738853,
0.018892403692007065,
0.017089754343032837
] | [
0.2873508930206299,
0.05613689869642258,
-0.047048766165971756,
0.10890509188175201,
0.003392750397324562,
-0.35867851972579956,
-0.21865133941173553,
-0.03534916788339615,
-0.19629864394664764,
-0.29548460245132446,
-0.14589914679527283,
-0.0504458025097847,
0.09644784778356552,
0.6371724009513855,
-0.16804714500904083,
0.21080048382282257,
0.3010839819908142,
0.11166983097791672,
-0.16031813621520996,
-0.23271067440509796,
-0.5724174380302429,
-0.16214387118816376,
0.21233145892620087,
-0.23801814019680023,
0.1975659728050232,
-0.25670158863067627,
-0.08996043354272842,
-0.17625249922275543,
-0.28323617577552795,
-0.19341349601745605,
-0.31915128231048584,
0.41768819093704224,
-0.06066001579165459,
0.1436949074268341,
-0.2690425515174866,
-0.31462252140045166,
0.023782068863511086,
-0.07162132114171982,
0.04624796658754349,
-0.49535828828811646,
-0.26023462414741516,
0.078434519469738,
-0.11950106918811798,
0.5929621458053589,
-0.051711078733205795,
-0.46594688296318054,
-1.6399520635604858,
0.4240144193172455,
-0.6219173073768616,
0.5576764345169067,
-0.5266641974449158,
0.2464120239019394,
0.2735496163368225,
0.41734862327575684,
-0.5176863670349121,
0.4356857240200043,
0.19901613891124725,
0.1625777781009674,
-0.3254834711551666,
-0.03228263184428215,
0.14249473810195923,
-0.015918433666229248,
0.07408736646175385,
0.13809746503829956,
0.2524905502796173,
-0.03334544599056244,
0.021543003618717194,
-0.2104940116405487,
-0.33377501368522644,
-0.17698070406913757,
-0.1029084101319313,
-0.5898140072822571,
-0.4498915672302246,
-0.0008416177006438375,
0.007637374568730593,
0.24598900973796844,
0.06781750172376633,
-0.030131837353110313,
0.6796122193336487,
-0.2471819370985031,
-0.27726081013679504,
0.19152626395225525,
-0.13934803009033203,
0.04380617290735245,
0.5374981760978699,
0.0583857037127018,
-0.2482283115386963,
0.1799512356519699,
-0.15476979315280914,
-0.09202399849891663,
0.08451496064662933,
-0.5260801911354065,
0.8970885276794434,
0.13944797217845917,
0.36375555396080017,
0.11889605224132538,
0.771500825881958,
-0.11209434270858765,
0.23010075092315674,
0.04712517932057381,
0.19955164194107056,
0.08719971776008606,
-0.037701565772295,
-0.26880156993865967,
-0.28796297311782837,
-0.32008540630340576,
-0.27084362506866455,
-0.43701887130737305,
0.2971002757549286,
-0.28629204630851746,
-0.008250802755355835,
0.13951051235198975,
-0.1956435739994049,
0.17426195740699768,
-0.24651671946048737,
0.2226337194442749,
0.5160028338432312,
-0.28860747814178467,
-0.2727147936820984,
-0.15094208717346191,
-0.0752473995089531,
1.0107676982879639,
0.11916365474462509,
0.27316591143608093,
-0.09768480062484741,
0.05278021842241287,
0.556559145450592,
0.08336473256349564,
-0.3695988953113556,
0.46876010298728943,
0.20990200340747833,
0.5193297266960144,
-0.4602304995059967,
-0.22364602982997894,
0.16408057510852814,
0.006667213514447212,
-0.10657001286745071,
0.23304161429405212,
0.3699896037578583,
0.11847086995840073,
-0.2960588037967682,
-0.6969156265258789,
-0.6123335957527161,
-0.16373084485530853,
0.18122795224189758,
-0.22952912747859955,
-0.3281426429748535,
-0.22432826459407806,
-0.2957175374031067,
-0.18759550154209137,
-0.026029814034700394,
-0.21111616492271423,
-0.4895182251930237,
0.11566166579723358,
0.4183609187602997,
0.6803170442581177,
-0.06561040878295898,
-0.360353022813797,
0.546751081943512,
-0.05023064464330673,
0.23412363231182098,
0.0763750895857811,
-0.12809808552265167,
-0.480426549911499,
0.013034597039222717,
-0.36108916997909546,
0.09445537626743317,
0.5890910029411316,
0.30528539419174194,
-0.12361279129981995,
-0.3479752838611603,
-0.31688886880874634,
0.02859746292233467,
-0.25595414638519287,
0.25185003876686096,
0.4040675163269043,
0.4733993411064148,
0.1070169135928154,
0.15057680010795593,
0.49971726536750793,
-0.6315411329269409,
0.20782235264778137,
-0.1171322613954544,
-0.558602511882782,
0.6165632009506226,
-0.14957255125045776,
0.39759907126426697,
0.18521805107593536,
-0.09269105643033981,
0.09044817835092545,
-0.21225567162036896,
-0.32828953862190247,
0.3770328760147095,
-0.30684348940849304,
1.4060721397399902,
-0.6151989698410034,
0.3089916408061981,
1.3585220575332642,
0.22540466487407684,
-0.4211428165435791,
-0.31021541357040405,
0.31826961040496826,
0.10567061603069305,
-0.22495988011360168,
-0.7087630033493042,
0.20622169971466064,
0.2354329377412796,
-0.18744374811649323,
-0.5405343770980835,
-0.1619061678647995,
0.26912155747413635,
-0.26617512106895447,
0.14968955516815186,
-0.4355688989162445,
0.12828317284584045,
-0.03615839034318924,
-0.065778948366642,
0.43607473373413086,
-0.4302433133125305,
-0.008483696728944778,
0.8987815380096436,
-0.446533739566803,
0.44504281878471375,
0.8319784998893738,
0.04032285884022713,
0.5591362118721008,
0.673324465751648,
0.6386162638664246,
0.40498086810112,
-0.6434770226478577,
0.2357301563024521,
-0.2851271629333496,
0.26726898550987244,
-0.5894460678100586,
-0.34578627347946167,
0.08456272631883621,
-0.319026917219162,
-0.014071553945541382,
0.005267246160656214,
-0.030725684016942978,
0.15563485026359558,
0.18764667212963104,
-0.16038808226585388,
0.4458855092525482,
0.37237364053726196,
-0.2425137460231781,
-0.23799476027488708,
-0.1715046912431717,
-0.42626091837882996,
0.09082328528165817,
-0.16419050097465515,
0.4435127377510071,
-0.08544403314590454,
-0.11522515118122101,
-0.016979467123746872,
0.15385398268699646,
0.11278098821640015,
0.14542441070079803,
0.43216437101364136,
0.20436227321624756,
0.09408450871706009,
-0.0819711908698082,
-0.28930866718292236,
0.29829123616218567,
-0.022776680067181587,
-0.42617008090019226,
-0.5966809988021851,
-0.8041478991508484,
0.7559745907783508,
0.17938537895679474,
0.759004533290863,
-0.0788467526435852,
-0.21690116822719574,
-0.10669761896133423,
-0.013647717423737049,
-0.8534117937088013,
0.22077441215515137,
0.44152453541755676,
-0.14272966980934143,
-0.2998353838920593,
-0.22534887492656708,
0.3229718506336212,
1.1326934099197388,
-0.2957663834095001,
0.04322626441717148,
-0.14906443655490875,
0.015312072820961475,
-0.364253968000412,
-0.024776238948106766,
-0.11799284815788269,
-0.10337790101766586,
0.18900126218795776,
0.06649897247552872,
-0.32521140575408936,
0.6064712405204773,
0.3280612528324127,
-0.2560878396034241,
0.12056326121091843,
-0.009781085886061192,
-0.1436055302619934,
-0.6043605804443359,
0.02115979604423046,
0.3486138582229614,
-0.372982919216156,
0.05054740607738495,
-0.2687685787677765,
-0.06917885690927505,
0.09014422446489334,
-6.233913421630859,
-0.3881056606769562,
-0.31715941429138184,
-0.4133063852787018,
-0.2762480080127716,
0.14431743323802948,
0.9125500321388245,
-0.4616582989692688,
-0.06688543409109116,
-0.19007465243339539,
0.08843693137168884,
0.7534444332122803,
0.321571946144104,
0.4245434105396271,
-0.037349507212638855,
0.8232636451721191,
-0.018666792660951614,
0.3157564699649811,
0.18454726040363312,
-0.034389689564704895,
0.04913691058754921,
-0.04483019933104515,
-0.15581290423870087,
0.58003169298172,
0.1149788424372673,
0.3138175904750824,
-0.7334548234939575,
0.4852428734302521,
0.13854210078716278,
-0.03530449420213699,
0.4590732157230377,
-0.4081854820251465,
-0.07668071240186691,
0.06498699635267258,
0.5003306269645691,
0.07294394075870514,
0.01933734118938446,
0.3867577016353607,
0.09633004665374756,
0.16392944753170013,
0.10730502009391785,
0.5384114980697632,
0.025583414360880852,
-0.2813190519809723,
0.2967982888221741,
-0.2557457387447357,
-0.16837061941623688,
0.4057140052318573,
-0.24277472496032715,
0.44631674885749817,
-0.0279927309602499,
-0.40825355052948,
0.07969655096530914,
-0.11801055073738098,
-0.1776130050420761,
-0.046157579869031906,
0.3502608835697174,
-0.017436636611819267,
-0.34491080045700073,
-0.5524513125419617,
0.31163015961647034,
-0.3014949858188629,
0.19441041350364685,
-0.7648565769195557,
-0.2542373836040497,
-0.3669270873069763,
-0.5932186245918274,
-0.5800090432167053,
0.051523130387067795,
-0.27389684319496155,
-0.26908889412879944,
0.5815987586975098,
0.15878790616989136,
-0.7542903423309326,
-0.03097677044570446,
-0.7517127394676208,
0.434391587972641,
0.23466618359088898,
0.06559236347675323,
0.06039901077747345,
-0.47643810510635376,
0.16946619749069214,
-0.3160642981529236,
-0.14724628627300262,
-0.35728198289871216,
-0.5032030940055847,
-0.04702380299568176,
-0.09487438946962357,
-0.3167785108089447,
0.011091107502579689,
0.25044968724250793,
-0.2539233863353729,
0.4116051495075226,
0.5397440195083618,
0.25684186816215515,
0.48763367533683777,
0.28218260407447815,
0.1881505399942398,
0.2522287964820862,
-0.11426737904548645,
0.3730640709400177,
-0.1960747241973877,
-0.5818986892700195,
-1.143465518951416,
-0.3919095993041992,
0.02586906962096691,
-0.34376922249794006,
0.027536828070878983,
0.38507765531539917,
-0.7872844934463501,
-0.35408300161361694,
0.28358811140060425,
-0.023669136688113213,
-0.5774880647659302,
0.268788605928421,
-0.22519683837890625,
0.04979140684008598,
0.13790656626224518,
0.1679157167673111,
-0.32974758744239807,
0.16742520034313202,
0.27022674679756165,
0.21785883605480194,
0.15743106603622437,
0.5660025477409363,
0.1357795149087906,
0.1317080408334732,
0.1537313163280487,
-0.21222291886806488,
-0.07826977968215942,
0.5811944007873535,
0.3539717495441437,
0.011577952653169632,
-0.13816241919994354,
0.34656909108161926,
-0.41074684262275696,
-0.5989896059036255,
0.4988447427749634,
-0.04033118486404419,
0.07717975974082947,
0.11925330758094788,
0.2246006429195404,
0.12179380655288696,
-0.10940577834844589,
0.3080417513847351,
-0.06884294003248215,
-0.06286712735891342,
0.6401861310005188,
0.19263601303100586,
0.44213762879371643,
-0.3149242401123047,
-0.3084236681461334,
0.04166591167449951,
0.31452226638793945,
0.14353354275226593,
-0.059158746153116226,
0.36174118518829346,
0.3390917479991913,
-0.5700162649154663,
-0.41470083594322205,
-0.39891037344932556,
-0.13151246309280396,
-1.3494809865951538,
-0.16334281861782074,
0.47544172406196594,
-0.11516640335321426,
-0.38809627294540405,
0.15164607763290405,
-0.12286598235368729,
-0.1128774955868721,
-0.08151524513959885,
-0.1551569551229477,
-0.20832042396068573,
-0.3127634525299072,
-0.3032713532447815,
0.1421540230512619,
0.4096321761608124,
0.33072325587272644,
-0.2741287052631378,
-0.20244012773036957,
0.2303214818239212,
-0.35724106431007385,
-0.5655306577682495,
0.4032164514064789,
0.35142508149147034,
0.1707763522863388,
0.5553964376449585,
-0.330310583114624,
-0.19364280998706818,
0.46053972840309143,
0.3199622929096222,
0.23022334277629852,
0.43072420358657837,
0.3193368911743164,
-0.2744942903518677,
-0.2939663529396057,
0.38186371326446533,
-0.4835643172264099,
-0.2776017189025879,
-0.19342857599258423,
0.223103865981102,
0.4790598452091217,
-0.41727858781814575,
0.20873776078224182,
0.19217433035373688,
-0.3984108567237854,
0.07729696482419968,
-0.12791641056537628,
-0.46532759070396423,
0.27937331795692444,
-0.15992018580436707,
0.16945597529411316,
0.09151998162269592,
0.36583441495895386,
-0.13986030220985413,
0.2217736542224884,
-0.009677902795374393,
-0.24355672299861908,
-0.6055132150650024,
0.3648225963115692,
0.3744271397590637,
0.1499560922384262,
-0.3861829340457916,
-0.12733706831932068,
-0.17641402781009674,
0.22558875381946564,
0.39857447147369385,
-0.2852330803871155,
-0.0037954668514430523,
-0.06912367790937424,
-0.24808570742607117,
-0.13943107426166534,
-0.26894375681877136,
0.480501651763916,
-0.3283787667751312,
0.08332645148038864,
-0.22258441150188446,
0.15764716267585754,
-0.10050813853740692,
0.3401189148426056,
0.05338127538561821,
0.19082774221897125,
-0.5264648199081421,
-0.6771060824394226,
-0.5634743571281433,
0.3098958134651184,
0.2766543924808502,
-0.2585882544517517,
-0.28149062395095825,
-0.2078923135995865,
0.5627183318138123,
-0.36112767457962036,
-0.2800670266151428,
0.15144415199756622,
0.3917081356048584,
0.42662614583969116,
-0.47969043254852295,
-0.24418924748897552,
-0.3190392553806305,
-0.08419740945100784,
0.27934661507606506,
-0.385386198759079,
-0.588125467300415,
-0.015733448788523674,
0.378694623708725,
0.060708288103342056,
-0.12888015806674957,
-0.508632242679596,
-0.05004648491740227,
-0.11848501116037369,
-0.4378517270088196,
-0.31640493869781494,
0.2608434557914734,
0.24298059940338135,
0.1854509860277176,
0.17201809585094452,
-0.4605906009674072,
-0.2645114064216614,
-0.15674734115600586,
-0.0660165548324585,
-0.0351608470082283,
-0.19577032327651978,
-0.0806095227599144,
0.06399394571781158,
0.40748944878578186,
-0.22368530929088593,
0.42137181758880615,
0.11659454554319382,
0.2646665871143341,
-0.42285802960395813,
-0.40915700793266296,
-0.07126306742429733,
-0.42677170038223267,
0.0720076709985733,
0.061550069600343704,
-0.07176987081766129,
0.9323276281356812,
0.2217720001935959,
-0.1977822333574295,
0.007296687923371792,
-0.3738080561161041,
0.5728312730789185,
0.8773515224456787,
-0.5997875332832336,
0.3458021283149719,
0.38268619775772095,
-0.4222584366798401,
0.8403995037078857,
-0.1526128649711609,
0.16911286115646362,
0.16647204756736755,
-0.12898017466068268,
-0.09395861625671387,
0.5520673990249634,
-0.5813807249069214,
-0.20045752823352814,
-0.044249989092350006,
-0.4747987389564514,
0.6447718739509583,
-0.07754473388195038,
-0.20250965654850006,
0.19697166979312897,
0.17646493017673492,
-0.18357400596141815,
-0.43042346835136414,
0.248319610953331,
0.3534490764141083,
0.5504689812660217,
-0.1088196262717247,
0.11651156842708588,
0.5663474202156067,
0.9640011787414551,
0.014686358161270618,
0.09834037721157074,
-0.09141860157251358,
-0.033574897795915604,
-0.08070292323827744,
-0.37264207005500793,
-0.284309983253479,
0.41639772057533264,
0.9958469271659851,
-0.16086435317993164,
-0.13437581062316895,
-0.0965539813041687,
-0.4034557044506073,
0.4171193242073059,
-0.16808336973190308,
0.11866962164640427,
-0.30286261439323425,
0.13766556978225708,
0.03633308783173561,
0.45515966415405273,
-0.17457297444343567,
0.0010766430059447885,
-0.18788497149944305,
-0.31144410371780396,
0.16682544350624084,
-0.1426272988319397,
-0.1902466118335724,
-0.14505106210708618,
-0.10579940676689148,
0.6537221670150757,
-0.09022606164216995,
0.2713333070278168,
0.2582816779613495,
0.4404161870479584,
0.830531656742096,
-0.07967767119407654,
0.42719566822052,
0.042781442403793335,
-0.12563692033290863,
0.1137268915772438,
-0.5115547776222229,
-0.046251751482486725,
-0.13516980409622192,
-0.3408648371696472,
0.3264835476875305,
-0.05005544424057007,
0.23337675631046295,
0.6298486590385437,
-0.21064746379852295,
-0.2446298599243164,
-0.26956379413604736,
-0.2050662487745285,
-0.05700785666704178,
0.014652678743004799,
-0.23795463144779205,
0.34181690216064453,
-0.06275898218154907,
-0.01473938673734665,
-0.394300639629364,
-0.4051732122898102,
0.0656825602054596,
0.42219772934913635,
-0.5287988781929016,
0.13765519857406616,
0.2604024410247803,
0.4012451469898224,
-0.11202317476272583,
0.5922490954399109,
-0.27729731798171997,
-0.2807776629924774,
0.08918895572423935,
0.21373522281646729,
-0.38337957859039307,
0.3555620312690735,
-0.3129972219467163,
-0.4085193872451782,
-0.7206729054450989,
0.09854891896247864,
0.5366480946540833,
0.06280319392681122,
-0.42451754212379456,
0.05638395994901657,
-0.0817468911409378,
0.2102738916873932,
0.3265399634838104,
-0.09853806346654892,
0.11354311555624008,
-0.17181003093719482,
-0.21857503056526184,
0.04909108951687813,
0.16028468310832977,
-0.010099963285028934,
0.1476036012172699,
0.14846161007881165,
0.11965813487768173,
0.2722283601760864,
-0.03633887320756912,
0.30447855591773987,
-0.2458830624818802,
-0.003361616749316454,
-0.42566004395484924,
0.057983770966529846,
-0.3544987440109253,
0.1023036539554596,
-0.017506439238786697,
0.04806296527385712,
0.18760369718074799,
-0.3998643457889557,
-0.15681159496307373,
0.2607852518558502,
0.057939767837524414,
0.1792793720960617,
-0.1934981793165207,
0.5569068789482117,
-0.30476778745651245,
-0.24080446362495422,
-0.6843827962875366,
0.2727266848087311,
0.16046138107776642,
0.09091352671384811,
-0.08571380376815796,
-0.5479187965393066,
0.16026060283184052,
-0.07033517211675644,
-0.07833480834960938,
-0.33785727620124817,
0.7079133987426758,
-0.04575302079319954
] |
BACKGROUND: The unpredictable nature of the potentially devastating impact of 2009 pH1N1 influenza pandemic highlights the need for pandemic preparedness planning, where modeling studies could be most useful for simulations of possible future scenarios. METHODS: A compartmental model with pre-symptomatic and asymptomatic influenza infections is proposed which incorporates age groups as well as intervention measures such as age-specific vaccination, in order to study spread of influenza in a community. RESULTS: We derive the basic reproduction number and other effective reproduction numbers under various intervention measures. For illustration, we make use of the Pneumonia and Influenza (P&I) mortality data and vaccination data of the very young (age 0-2) and the very old (age >64) during 2004-2005 Taiwan winter influenza season to fit our model and to compute the relevant reproduction numbers. The reproduction number for this winter flu season is estimated to be slightly above one (~1.0001). CONCLUSIONS: Comparatively large errors in fitting the P&I mortality data of the elderly (>64) were observed shortly after winter school closings in January, which may indicate the impact of younger, more active age groups transmitting influenza to other age groups outside of the school settings; in particular, to the elderly in the households. Pre-symptomatic infections seemed to have little effect on the model fit, while asymptomatic infection by asymptomatic infectives has a more pronounced impact on the model fit for the elderly mortality, perhaps indicating a larger role in disease transmission by asymptomatic infection. Simulations indicate that the impact of vaccination on the disease incidence might not be fully revealed in the change (or the lack thereof) in the effective reproduction number with interventions, but could still be substantial. The estimated per contact transmission probability for susceptible elderly is significantly higher than that of any other age group, perhaps highlighting the vulnerability of the elderly due to close contacts with their caretakers from other age groups. The relative impact of targeting the very young and the very old for vaccination was weakened by their relative inactivity, thus giving evidence of the lack of impact of vaccinating these two groups on the overall transmissibility of the disease in the community. This further underscores the need for morbidity-based strategy to prevent elderly mortality. | [
-0.01845363900065422,
0.023378171026706696,
0.0032460526563227177,
0.03325515240430832,
0.039903804659843445,
-0.016317298635840416,
0.011346239596605301,
0.011888631619513035,
-0.018052855506539345,
-0.02850833535194397,
-0.0030922414734959602,
0.016010485589504242,
-0.004543935880064964,
-0.0024575279094278812,
-0.012585143558681011,
-0.01551678217947483,
-0.005398990120738745,
0.01064140722155571,
0.013139627873897552,
-0.01605510711669922,
-0.028956271708011627,
0.020233886316418648,
0.012677432037889957,
0.02555079385638237,
0.022683916613459587,
0.004832747392356396,
0.012706920504570007,
-0.027905941009521484,
-0.003318668343126774,
-0.017236359417438507,
0.007445519790053368,
0.03151634335517883,
0.007775843143463135,
0.009151482954621315,
0.011125097051262856,
-0.024059927091002464,
-0.0048673744313418865,
0.02755412459373474,
-0.01720588281750679,
-0.004404391627758741,
0.012680181302130222,
-0.017986275255680084,
0.004031814634799957,
-0.011195393279194832,
-0.00812673382461071,
0.009803002700209618,
-0.003892952809110284,
-0.01412077248096466,
-0.023352686315774918,
0.00907706469297409,
-0.01161138340830803,
0.0016076022293418646,
-0.011794289574027061,
-0.022417224943637848,
-0.007254059426486492,
-0.012972891330718994,
0.022328464314341545,
-0.016020968556404114,
-0.03540394827723503,
0.012686898931860924,
-0.005472069140523672,
0.006487762089818716,
0.004923076834529638,
-0.037669260054826736,
-0.007837925106287003,
-0.06643986701965332,
-0.005555191542953253,
0.014737885445356369,
0.002848244272172451,
-0.0017006732523441315,
-0.01137513853609562,
0.008001523092389107,
-0.010947286151349545,
-0.007834945805370808,
-0.02203533425927162,
0.0007279720157384872,
-0.001716572791337967,
0.021106760948896408,
0.019938867539167404,
0.0005594659596681595,
-0.013633709400892258,
0.002056051976978779,
0.026869941502809525,
0.02575874514877796,
-0.015066917054355145,
0.020540373399853706,
-0.026129435747861862,
0.02874881960451603,
-0.009076680056750774,
0.011041229590773582,
0.025688305497169495,
0.006380593404173851,
-0.03879357874393463,
-0.005085304379463196,
-0.017133161425590515,
-0.012932070530951023,
-0.008845379576086998,
0.01631277985870838,
-0.00644035916775465,
-0.001127209048718214,
-0.012142112478613853,
0.009369291365146637,
0.016018172726035118,
0.0028437385335564613,
-0.0042032888159155846,
0.012222422286868095,
-0.03333139047026634,
-0.012727277353405952,
0.017961272969841957,
0.0036586392670869827,
0.013217081315815449,
-0.010935707949101925,
0.0005517001263797283,
0.014655868522822857,
-0.002164012286812067,
-0.023526538163423538,
0.025506047531962395,
0.03644981235265732,
0.015622777864336967,
0.010542783886194229,
0.00268773315474391,
0.012600407004356384,
0.0046117473393678665,
0.018821850419044495,
0.006102195009589195,
0.010662702843546867,
0.018062926828861237,
-0.011674763634800911,
0.006985815707594156,
0.0035843222867697477,
-0.01069556549191475,
-0.009674130007624626,
-0.003375413827598095,
0.00205634324811399,
0.0013060090132057667,
0.008603359572589397,
0.004433469846844673,
0.006099410355091095,
-0.005769180133938789,
-0.023542502894997597,
-0.026610247790813446,
0.012203244492411613,
-0.001632952131330967,
0.01495666429400444,
0.012468588538467884,
0.0157693549990654,
-0.014215105213224888,
0.016298441216349602,
0.025235209614038467,
0.025314930826425552,
0.004817304201424122,
-0.01117916963994503,
-0.02168196439743042,
-0.015740063041448593,
0.005777750164270401,
-0.009589163586497307,
-0.0014697543811053038,
-0.005971161182969809,
-0.009285899810492992,
0.012764930725097656,
-0.018009351566433907,
0.008052383549511433,
0.008056223392486572,
0.009976421482861042,
0.02467874437570572,
0.014580217190086842,
0.040980175137519836,
-0.0016069428529590368,
-0.01750115677714348,
0.00815529003739357,
-0.014228181913495064,
0.008835983462631702,
-0.010455704294145107,
0.014739135280251503,
0.04091498628258705,
-0.003136334242299199,
-0.012427153065800667,
0.011149594560265541,
-0.010939285159111023,
0.06648194789886475,
0.001707869116216898,
-0.013797919265925884,
-0.02316615916788578,
0.021466102451086044,
0.0005924247670918703,
-0.018121160566806793,
0.04080985486507416,
-0.014993631280958652,
0.006728379055857658,
-0.03001493029296398,
-0.0136997876688838,
-0.03999453783035278,
0.006125577259808779,
-0.01745978742837906,
-0.04250815510749817,
0.003146977396681905,
-0.02421480044722557,
0.013612555339932442,
-0.00591160636395216,
0.00597759522497654,
0.01673368737101555,
0.004228612408041954,
0.027708280831575394,
0.023540230467915535,
0.02121228165924549,
0.001588356215506792,
0.018559632822871208,
-0.00833310466259718,
-0.01790020987391472,
-0.019982201978564262,
0.04243100434541702,
-0.04342149570584297,
0.019442547112703323,
-0.011416006833314896,
-0.010756237432360649,
-0.008353834971785545,
0.006818252615630627,
0.03134822100400925,
0.006536179222166538,
-0.014464320614933968,
0.0015661946963518858,
0.02090991660952568,
-0.013480943627655506,
-0.01238339114934206,
0.014687464572489262,
-0.01087962556630373,
-0.011610826477408409,
0.014672819525003433,
0.0026185037568211555,
0.018177054822444916,
-0.02241731807589531,
-0.023435741662979126,
-0.01370466873049736,
0.007671608589589596,
-0.01627262495458126,
0.0037928582169115543,
0.014889337122440338,
-0.018490217626094818,
0.006444515660405159,
-0.012842213734984398,
-0.026320742443203926,
-0.011200488545000553,
0.0014185754116624594,
-0.008665959350764751,
0.015709135681390762,
-0.004845552612096071,
0.023040054365992546,
0.0015837992541491985,
-0.02495553344488144,
-0.010922165587544441,
0.008014347404241562,
-0.0018484857864677906,
-0.0014411816373467445,
-0.015178079716861248,
0.031182682141661644,
-0.022055014967918396,
0.02713901549577713,
-0.001221447717398405,
0.02408958598971367,
0.015410419553518295,
0.0056247347965836525,
0.005691473837941885,
-0.024076608940958977,
-0.02142391912639141,
0.013007808476686478,
0.019735023379325867,
0.022343507036566734,
0.02274826169013977,
0.017695214599370956,
-0.008562018163502216,
0.008535056374967098,
-0.01213087048381567,
-0.009693932719528675,
-0.08050940185785294,
-0.012315915897488594,
-0.017185384407639503,
-0.01722918264567852,
0.010693522170186043,
-0.021195674315094948,
-0.0002276781015098095,
0.0082808593288064,
-0.013809433206915855,
0.013433177024126053,
0.01593424752354622,
0.012938445433974266,
-0.009238991886377335,
0.04133622720837593,
-0.012573200277984142,
-0.002629113383591175,
0.00605173921212554,
0.03996722400188446,
-0.021215736865997314,
0.005855957977473736,
-0.0037915832363069057,
0.0036479802802205086,
0.019774356856942177,
-0.02657531574368477,
0.009716877713799477,
0.0026347569655627012,
0.011959429830312729,
0.0028993072919547558,
0.00545818917453289,
0.009600442834198475,
0.015818726271390915,
-0.050221022218465805,
-0.004609168507158756,
-0.019253838807344437,
0.010700368322432041,
-0.01416157465428114,
-0.0023243390023708344,
-0.023292526602745056,
-0.0006696004420518875,
-0.014008831232786179,
-0.0009276559576392174,
0.014203488826751709,
-0.02150910720229149,
-0.006779870949685574,
0.0082755908370018,
0.009068211540579796,
0.025269584730267525,
0.004244222771376371,
0.017535706982016563,
0.0044189151376485825,
-0.009349865838885307,
-0.010554788634181023,
0.025215962901711464,
0.015586312860250473,
-0.016791855916380882,
0.008229413069784641,
-0.013270322233438492,
0.014742698520421982,
-0.018434179946780205,
-0.012066072784364223,
-0.02511008456349373,
0.03572598099708557,
0.0027399305254220963,
0.011236407794058323,
-0.05058034509420395,
0.005573701579123735,
0.011895919218659401,
0.005787110887467861,
-0.008734568953514099,
0.007603977806866169,
-0.00823991373181343,
0.0038288612850010395,
-0.004707259591668844,
-0.005061892792582512,
0.03163159638643265,
-0.010748976841568947,
-0.017570393159985542,
-0.015400467440485954,
-0.03239705041050911,
-0.011362892575562,
-0.01759393885731697,
0.0062613715417683125,
-0.00824932660907507,
0.008657597936689854,
-0.02287035435438156,
0.003206993453204632,
0.019427746534347534,
0.0017076025251299143,
0.00640469416975975,
-0.012655386701226234,
-0.005636150948703289,
0.03352316841483116,
-0.03654016554355621,
0.006587018724530935,
-0.0036603594198822975,
-0.022932682186365128,
-0.0069715301506221294,
-0.013426010496914387,
0.01398705318570137,
0.01103023812174797,
0.011345863342285156,
-0.014353558421134949,
-0.010203813202679157,
-0.018581345677375793,
-0.04100313037633896,
0.019238334149122238,
0.006567968521267176,
-0.023798983544111252,
-0.026776030659675598,
-0.010852761566638947,
-0.025262542068958282,
0.013053025119006634,
-0.0024745501577854156,
0.0039277952164411545,
0.009366771206259727,
0.020778220146894455,
0.012218136340379715,
0.013142779469490051,
0.07152332365512848,
-0.023098010569810867,
0.006613476201891899,
-0.010906052775681019,
-0.0036969874054193497,
-0.017315097153186798,
0.00582951121032238,
-0.018285086378455162,
-0.008382401429116726,
-0.024341193959116936,
0.012695956975221634,
-0.01476207934319973,
0.02252747304737568,
-0.012679032981395721,
-0.02757463976740837,
-0.02444581687450409,
0.009790435433387756,
-0.0018446985632181168,
0.011091846972703934,
-0.00268362695351243,
-0.002962963655591011,
-0.013125569559633732,
-0.0120765445753932,
0.0027793662156909704,
0.0017824750393629074,
0.018893105909228325,
-0.009915776550769806,
-0.013636226765811443,
-0.0008447454310953617,
0.00834839791059494,
0.011629991233348846,
0.014652593992650509,
-0.006338215433061123,
-0.019878355786204338,
0.011525161564350128,
-0.006371324881911278,
0.02401033602654934,
-0.00671685254201293,
0.015057425014674664,
0.011087574996054173,
0.001502980594523251,
-0.016715217381715775,
-0.010149821639060974,
0.014549707993865013,
-0.03519738093018532,
0.02352423220872879,
-0.016146941110491753,
-0.010228686034679413,
-0.013242076151072979,
0.00238067377358675,
-0.016426775604486465,
0.0025513656437397003,
0.017185410484671593,
0.019496068358421326,
-0.012572376057505608,
0.004040689207613468,
0.007682121358811855,
-0.005683965981006622,
-0.0032633906230330467,
-0.021780770272016525,
-0.00985407643020153,
-0.06006680056452751,
0.018568415194749832,
-0.01894947700202465,
0.011247599497437477,
-0.010656582191586494,
-0.0047393497079610825,
-0.005215808749198914,
-0.008447831496596336,
-0.018552135676145554,
0.0340435616672039,
-0.007220247760415077,
0.0017813616432249546,
-0.019788313657045364,
-0.031155861914157867,
-0.002643296727910638,
-0.03143618255853653,
-0.04029286652803421,
-0.01420857198536396,
0.0038568200543522835,
-0.024089539423584938,
0.020810069516301155,
-0.005595538765192032,
-0.010656044818460941,
0.015040704980492592,
-0.005435788072645664,
-0.02085259184241295,
-0.07360155880451202,
-0.009815841913223267,
0.01175273023545742,
-0.01084879320114851,
-0.012059997767210007,
0.03107086755335331,
0.00014995294623076916,
-0.0007840909529477358,
-0.014254540205001831,
-0.011483781039714813,
0.003857470117509365,
-0.02192653715610504,
0.016009539365768433,
-0.00765160471200943,
0.014576159417629242,
0.015635734423995018,
-0.012945445254445076,
-0.00009146810043603182,
-0.0041876500472426414,
0.007529186084866524,
0.007647331804037094,
0.03239674121141434,
-0.03222813084721565,
-0.0137907974421978,
0.00786607712507248,
-0.08004630357027054,
-0.019110096618533134,
0.011118129827082157,
-0.011676293797791004,
-0.013560377061367035,
-0.012618793174624443,
0.01825677789747715,
-0.02183065563440323,
-0.00040987227112054825,
-0.015839792788028717,
0.014801854267716408,
-0.018327660858631134,
-0.009088024497032166,
-0.021927043795585632,
0.028679274022579193,
-0.007647422142326832,
0.028779692947864532,
-0.002922317013144493,
0.03504778817296028,
-0.018348056823015213,
0.01765473186969757,
0.02985445037484169,
-0.010549549013376236,
-0.012973226606845856,
-0.014574287459254265,
-0.017901083454489708,
-0.03392978012561798,
0.015357616357505322,
0.008765971288084984,
-0.014169417321681976,
-0.0066045974381268024,
-0.006557933054864407,
-0.0034712599590420723,
-0.0035639291163533926,
0.007819531485438347,
-0.010907506570219994,
0.03415883705019951,
-0.009421451948583126,
0.0220990888774395,
0.004865232855081558,
-0.0029009231366217136,
0.023803435266017914,
-0.015594827942550182,
0.012188015505671501,
0.007132134400308132,
0.04214644432067871,
0.00939142145216465,
-0.005006264429539442,
0.023631803691387177,
0.0053556859493255615,
0.011175546795129776,
-0.030782978981733322,
0.011081419885158539,
-0.005187843460589647,
0.0034870055969804525,
-0.010759850963950157,
-0.00384457316249609,
0.014991038478910923,
-0.007316695060580969,
0.010023219510912895,
-0.007782727479934692,
-0.00834483653306961,
-0.02345915324985981,
0.0714518129825592,
-0.022360805422067642,
0.01998114213347435,
-0.018623419106006622,
-0.005606494843959808,
0.00043689439189620316,
0.002213960513472557,
-0.017577646300196648,
-0.010875086300075054,
-0.016402054578065872,
0.005417847074568272,
-0.009361736476421356,
-0.012335797771811485,
0.013814781792461872,
0.006382856518030167,
0.02535058557987213,
0.009252700954675674,
-0.011224218644201756,
-0.010202692821621895,
0.004246576689183712,
-0.04510362446308136,
0.013201134279370308,
-0.03288178890943527,
-0.010379345156252384,
0.023429539054632187,
-0.005616961978375912,
0.002359437756240368,
0.007878227159380913,
-0.02877866104245186,
0.03203967958688736,
-0.005147245712578297,
-0.013505791313946247,
0.0016595028573647141,
-0.005976049695163965,
0.01866643875837326,
-0.0011913217604160309,
0.005364083684980869,
-0.00015770638128742576,
0.00675155408680439,
0.026323385536670685,
0.009721161797642708,
-0.0007838928140699863,
-0.006128481589257717,
0.003459703177213669,
0.012956044636666775,
-0.020905468612909317,
0.008469294756650925,
0.0036706330720335245,
0.011208850890398026,
0.02174246311187744,
-0.0033730489667505026,
-0.001368785509839654,
0.018907971680164337,
-0.005853691138327122,
-0.018723120912909508,
-0.029494550079107285,
-0.010102828964591026,
0.014613724313676357,
-0.0205085389316082,
-0.03443314880132675,
0.015330035239458084,
-0.0176639873534441,
0.01296340674161911,
-0.017795294523239136,
-0.0033345913980156183,
0.0074273222126066685,
-0.0012183396611362696,
-0.01703513041138649,
0.0022525452077388763,
0.017096174880862236,
-0.01853487454354763,
0.03049962967634201,
0.008317004889249802,
-0.006468767765909433,
0.014749930240213871,
0.013222767971456051,
0.03173178434371948,
0.009695447981357574,
0.0084372628480196,
0.004490824416279793,
-0.01861172541975975,
-0.039766501635313034,
0.007501645945012569,
-0.02422267012298107,
0.008039815351366997,
-0.014084248803555965,
0.013231223449110985,
-0.004200679250061512,
-0.007746832445263863,
0.003783837892115116,
0.010335166938602924,
0.0357586033642292,
0.005921737756580114,
-0.003256493015214801,
0.009762628003954887,
0.03400745987892151,
0.022487230598926544,
0.005240073427557945,
0.0058495583944022655,
-0.0023141077253967524,
0.007798852398991585,
-0.017821524292230606,
-0.00008695898577570915,
0.014371969737112522,
0.0097512137144804,
0.014180836267769337,
0.007042483892291784,
-0.009631253778934479,
0.004271097481250763,
0.024333681911230087,
-0.007365737110376358,
0.008033622056245804,
0.02076789364218712,
-0.000777889508754015,
-0.0107377078384161,
0.01530400849878788,
-0.013852611184120178,
0.01347033865749836,
0.005747818388044834,
-0.007901780307292938,
-0.02966790832579136,
0.009817621670663357,
-0.0005526500754058361,
0.031140390783548355,
-0.016985870897769928,
-0.015841862186789513,
-0.00919821672141552,
-0.005085953511297703,
-0.012226739898324013,
-0.0051774014718830585,
0.025081755593419075,
-0.010096235200762749,
0.003733459860086441,
0.011013489216566086,
-0.014769680798053741,
0.015436289831995964,
-0.005746375769376755,
0.0015879919519647956,
-0.007778641302138567,
-0.014944469556212425,
0.024098947644233704,
-0.00555057730525732,
0.003581325290724635,
-0.009887076914310455,
0.00836728885769844,
0.007857011631131172,
-0.0078964252024889,
0.02645283192396164,
0.013740697875618935,
-0.008319299668073654,
-0.021708788350224495,
0.005899506621062756,
0.011167359538376331,
-0.0037529519759118557,
-0.011463252827525139,
0.0099986232817173,
0.004361197352409363,
-0.02313850447535515,
-0.02975805103778839,
0.011347955092787743,
-0.0032215015962719917,
-0.01250927709043026,
0.02505573257803917,
0.002452233573421836,
-0.00843989010900259,
0.010196642950177193,
0.0448899082839489,
0.022282078862190247,
-0.01706012710928917,
0.006475766655057669,
-0.013755613937973976,
0.0019501500064507127,
-0.011280510574579239,
0.024531159549951553,
-0.012817813083529472,
-0.027989372611045837,
0.007824068889021873,
0.007090078666806221,
-0.024677403271198273,
0.008266760967671871,
0.017457693815231323,
-0.005641600117087364,
0.011710604652762413,
-0.015376116149127483,
0.00998014584183693,
0.004753291606903076,
-0.010411933064460754,
0.02747470512986183,
0.007632155902683735,
0.0031300645787268877,
-0.01292601227760315,
0.002549936529248953,
-0.01575671136379242,
0.01612875983119011,
-0.021274607628583908,
-0.024550680071115494,
-0.005729957949370146,
-0.02685730718076229,
0.0028664066921919584,
-0.0035173925571143627,
0.030019614845514297,
0.00009337929077446461
] | [
0.3571193218231201,
-0.18128855526447296,
-0.3583814203739166,
0.1578153669834137,
0.2802160382270813,
0.5510111451148987,
0.019800599664449692,
-0.11145684868097305,
-0.4831295907497406,
-0.5996518135070801,
0.22067095339298248,
0.04828653857111931,
0.12269756942987442,
0.3134773075580597,
-0.3394964635372162,
0.676071286201477,
0.09449262171983719,
0.47424888610839844,
-0.29935717582702637,
-0.28067660331726074,
-0.4527280628681183,
-0.3148145079612732,
-0.0315093919634819,
0.0827188640832901,
0.04965439438819885,
-0.13223420083522797,
0.18642102181911469,
-0.13410213589668274,
0.162468820810318,
-0.06070433929562569,
-0.33528003096580505,
0.48265865445137024,
0.09061407297849655,
0.09550453722476959,
0.007274520583450794,
-0.7432625889778137,
-0.10504286736249924,
0.0569092221558094,
0.21286676824092865,
-0.2737721800804138,
-0.006644468288868666,
-0.34995967149734497,
0.07041186839342117,
0.20962223410606384,
-0.24399705231189728,
-0.49176526069641113,
-1.2369862794876099,
0.10337301343679428,
-0.03707022964954376,
-0.13945208489894867,
0.3894962668418884,
-0.17654642462730408,
0.354926198720932,
0.39922380447387695,
-0.2632524073123932,
0.3607073426246643,
-0.18678078055381775,
0.07830161601305008,
0.0029999688267707825,
-0.25847724080085754,
0.2146155834197998,
-0.20642952620983124,
0.08859548717737198,
0.1028023287653923,
-0.01958988793194294,
0.1835218369960785,
0.5673167109489441,
0.08841755241155624,
0.026993311941623688,
-0.27714425325393677,
-0.2035140097141266,
-0.4968439042568207,
-0.15778663754463196,
0.07491122931241989,
-0.3439576029777527,
-0.10494006425142288,
-0.16143923997879028,
-0.2518121600151062,
0.5308594703674316,
-0.16199909150600433,
-0.24475622177124023,
-0.20731064677238464,
0.19540558755397797,
-0.5862528085708618,
0.7591544985771179,
0.39733701944351196,
0.14201800525188446,
0.36586394906044006,
-0.5307853817939758,
0.06167035177350044,
-0.0018289374420419335,
-0.3191480040550232,
0.48189985752105713,
0.46498382091522217,
0.0049707284197211266,
0.7135699391365051,
0.20882783830165863,
-0.013574461452662945,
0.15999890863895416,
-0.1184755340218544,
-0.369461327791214,
0.04342702776193619,
-0.12997934222221375,
-0.3175458014011383,
-0.6327311992645264,
-0.5640417337417603,
0.019245993345975876,
-0.30526766180992126,
-0.1417623907327652,
-0.05953318625688553,
-0.1671648472547531,
0.10554950684309006,
-0.23173053562641144,
-0.05688777565956116,
-0.14770841598510742,
0.26966559886932373,
0.12182720005512238,
-0.5417842864990234,
-0.011682379059493542,
0.1986202448606491,
-0.4164479672908783,
0.777529239654541,
-0.09728840738534927,
0.1851579248905182,
0.019820036366581917,
0.30888989567756653,
0.7383314967155457,
0.2329600751399994,
0.08112183958292007,
0.20113742351531982,
0.14510764181613922,
0.5188373923301697,
-0.6280753016471863,
-0.05064636096358299,
0.458162397146225,
-0.2955617606639862,
-0.3277486562728882,
0.32533785700798035,
0.21197041869163513,
-0.14677412807941437,
-0.5142701268196106,
-0.5008962750434875,
0.07077540457248688,
0.17626437544822693,
0.1590638905763626,
-0.18774108588695526,
-0.36168134212493896,
-0.33326154947280884,
-0.001438633189536631,
-0.1847846806049347,
0.23064807057380676,
-0.2335919439792633,
-0.5615085959434509,
-0.3655669093132019,
-0.02956448867917061,
0.04671485722064972,
-0.11893779039382935,
-0.14790579676628113,
-0.05982157588005066,
0.25651970505714417,
0.4294508397579193,
0.5303909778594971,
-0.48560088872909546,
-0.14430361986160278,
0.16230203211307526,
-0.17713876068592072,
0.4990609884262085,
0.5647225975990295,
-0.25309962034225464,
-0.03262903913855553,
-0.5428908467292786,
-0.045787643641233444,
-0.3123975098133087,
-0.3847655653953552,
-0.190638467669487,
0.36694321036338806,
0.5256947875022888,
0.09016837924718857,
0.45071518421173096,
0.006285561714321375,
-0.4136471748352051,
-0.2822364568710327,
-0.22429180145263672,
-0.5105584263801575,
0.27911677956581116,
-0.3770362138748169,
0.040305245667696,
0.023749420419335365,
-0.02841881290078163,
-0.03611484542489052,
-0.20347543060779572,
-0.1504494547843933,
0.662377119064331,
-1.082189679145813,
1.01286780834198,
-0.4532747268676758,
0.06801280379295349,
1.1577353477478027,
0.19611874222755432,
-0.08965036273002625,
-0.13604135811328888,
0.23790095746517181,
0.2545802593231201,
-0.1951121687889099,
-0.5740913152694702,
-0.03754936531186104,
-0.03426448255777359,
-0.19245152175426483,
-0.23248380422592163,
0.04682973399758339,
0.4371058940887451,
0.1502959430217743,
0.1853669136762619,
-0.477931946516037,
-0.17610228061676025,
0.028336312621831894,
-0.23821935057640076,
0.2782363295555115,
-0.07306403666734695,
0.026440279558300972,
0.3902231752872467,
-0.49627071619033813,
0.37967240810394287,
0.36595064401626587,
0.30408984422683716,
0.5893491506576538,
0.7474164962768555,
-0.10575034469366074,
0.9316109418869019,
-0.4499574899673462,
0.3078097999095917,
0.08884883671998978,
0.19343046844005585,
-0.3030606210231781,
-0.3283829092979431,
0.12507516145706177,
-0.20483016967773438,
-0.1785474717617035,
-0.006157542113214731,
0.22710281610488892,
0.39211171865463257,
0.13421796262264252,
-0.4111015200614929,
-0.016245923936367035,
0.05375811457633972,
-0.23819005489349365,
-0.5133433938026428,
0.047445084899663925,
-0.6073436141014099,
-0.0959932953119278,
-0.10221268981695175,
0.41764652729034424,
0.18361718952655792,
-0.2688179612159729,
0.08385501801967621,
0.0675317645072937,
-0.013900499790906906,
-0.3399187922477722,
0.18206964433193207,
-0.29542362689971924,
0.11307327449321747,
-0.030754879117012024,
0.24591442942619324,
0.09772707521915436,
0.2121783047914505,
-0.469760924577713,
-0.7908059358596802,
-0.8474842309951782,
0.3379528224468231,
0.5791156888008118,
0.5729200839996338,
0.18632744252681732,
-0.4431893229484558,
0.0705409124493599,
0.29391708970069885,
-0.7078304886817932,
0.3288266360759735,
0.6431180238723755,
-0.5424290895462036,
-0.40112024545669556,
-0.09031888842582703,
0.13801687955856323,
0.5909335017204285,
-0.293821781873703,
-0.24542111158370972,
-0.24406051635742188,
0.2989417314529419,
-0.027961384505033493,
-0.3159925639629364,
-0.06705940514802933,
-0.16814184188842773,
0.4855022430419922,
-0.11019966006278992,
-0.44206470251083374,
0.6183760166168213,
0.5650059580802917,
-0.16117215156555176,
0.22588126361370087,
0.2835509181022644,
-0.1439480036497116,
-0.24592941999435425,
0.1741015464067459,
0.12705953419208527,
-0.40958261489868164,
-0.18920089304447174,
0.09093856066465378,
-0.1156110018491745,
0.09746812283992767,
-6.265981197357178,
0.08855943381786346,
-0.4272095561027527,
-0.14535194635391235,
-0.5650259852409363,
0.23915261030197144,
1.0908100605010986,
0.17809852957725525,
0.08075683563947678,
-0.12878437340259552,
0.6081007719039917,
0.2152498960494995,
0.14901429414749146,
0.44419488310813904,
0.2859252393245697,
0.31493812799453735,
0.2894294261932373,
0.29289600253105164,
0.250969797372818,
0.04594720900058746,
-0.08041618019342422,
-0.23684711754322052,
-0.24590903520584106,
0.4893806278705597,
0.43945083022117615,
0.2176685482263565,
-0.7966476082801819,
-0.07867599278688431,
-0.32040494680404663,
0.2442425787448883,
0.30365538597106934,
-0.47009947896003723,
0.08017943054437637,
-0.15752513706684113,
0.17359673976898193,
0.18321089446544647,
0.1345297396183014,
0.16209039092063904,
0.23355670273303986,
-0.36326950788497925,
0.10152619332075119,
0.6046744585037231,
-0.30241814255714417,
-0.05816381424665451,
-0.08242816478013992,
0.21571913361549377,
0.05859909951686859,
0.10287754982709885,
-0.2275463044643402,
0.7946598529815674,
-0.11434470117092133,
0.00004514881220529787,
0.05878005549311638,
0.42181336879730225,
0.10088194161653519,
-0.07298140227794647,
-0.14669069647789001,
0.4875047206878662,
-0.16798438131809235,
0.16930189728736877,
0.4829902648925781,
-0.06673724204301834,
0.5554909706115723,
-0.4251879155635834,
-0.22363178431987762,
0.2643950283527374,
-0.8764413595199585,
-0.5593987107276917,
-0.11517644673585892,
0.20823140442371368,
-0.275005042552948,
-0.20383843779563904,
0.22176730632781982,
-0.7229411602020264,
-0.15307386219501495,
-0.5121928453445435,
-0.009209442883729935,
0.30028578639030457,
0.05445854738354683,
-0.3757898509502411,
-0.0712888166308403,
-0.7058184146881104,
0.14334061741828918,
0.1813051551580429,
0.2805425822734833,
0.08950449526309967,
-0.2063581347465515,
-0.21842654049396515,
-0.3772369623184204,
0.29902383685112,
0.5066413879394531,
-0.3291746973991394,
0.15415117144584656,
0.22086195647716522,
0.7353364825248718,
0.7697946429252625,
0.4880421757698059,
-0.06345421820878983,
0.21000078320503235,
-0.10441727936267853,
0.7296717166900635,
-0.29357442259788513,
-0.49768322706222534,
-0.6840347051620483,
0.06688375025987625,
0.08206981420516968,
-0.38419976830482483,
-0.06958647072315216,
0.8237491846084595,
-0.7578994035720825,
0.18216809630393982,
-0.09783821552991867,
-0.1940889060497284,
-0.6736614108085632,
0.5638908743858337,
-0.39304327964782715,
0.060483939945697784,
0.28464841842651367,
0.7420293688774109,
0.08935844153165817,
0.5477198362350464,
0.17637969553470612,
-0.40178218483924866,
0.2765890657901764,
0.05814797431230545,
-0.38206082582473755,
0.31256580352783203,
0.3349750339984894,
-0.4737945795059204,
-0.4049965441226959,
0.23908765614032745,
0.5918086767196655,
-0.40738242864608765,
-0.30383384227752686,
0.25939685106277466,
-0.053424298763275146,
-0.07731974869966507,
-0.1533765345811844,
0.1945505142211914,
-0.14635223150253296,
0.09241639822721481,
-0.10157284885644913,
-0.553798496723175,
0.047286659479141235,
0.010363356210291386,
0.25319069623947144,
-0.19439935684204102,
-0.25165536999702454,
0.1015079915523529,
-0.039640162140131,
-0.016576193273067474,
-0.07501407712697983,
0.4910385310649872,
-0.055843040347099304,
-0.6991320252418518,
-0.13739299774169922,
0.4283631443977356,
-0.06310827285051346,
-0.4897145926952362,
-0.2672104239463806,
0.4609670639038086,
-0.2814231812953949,
-1.1067134141921997,
-0.26801612973213196,
0.22246816754341125,
-0.07332892715930939,
-0.03828979283571243,
-0.29915064573287964,
0.0019253005739301443,
0.4301130175590515,
-0.03307100385427475,
-0.39737656712532043,
0.02891857549548149,
0.10640832781791687,
0.07319089770317078,
-0.23346874117851257,
-0.1650983691215515,
0.2887440025806427,
-0.287007600069046,
0.20726288855075836,
0.09508461505174637,
-0.3012504279613495,
-0.24840359389781952,
0.3316120505332947,
0.5529565215110779,
0.6295121908187866,
0.21740013360977173,
0.03608722612261772,
-0.6504778861999512,
-0.05567695572972298,
-0.15184636414051056,
-0.07514379918575287,
0.5918553471565247,
-0.1834784895181656,
-0.14517368376255035,
-0.17116960883140564,
-0.01775236800312996,
0.39464959502220154,
0.14863218367099762,
-0.13665620982646942,
0.015917496755719185,
0.242312952876091,
-0.5206671357154846,
0.18984150886535645,
0.1877516359090805,
-0.42663314938545227,
-0.00895651988685131,
-0.4866497814655304,
-0.10170391201972961,
-0.41444429755210876,
-0.2944668233394623,
-0.27572736144065857,
-0.4027184545993805,
0.41674110293388367,
-0.08451257646083832,
0.2643495798110962,
0.06345286220312119,
-0.39515912532806396,
-0.0008831129525788128,
0.38990479707717896,
0.3622190058231354,
0.17218796908855438,
-0.0964273139834404,
0.002604564419016242,
-0.002953968243673444,
0.2332017868757248,
0.44867774844169617,
-0.9528358578681946,
-0.24368375539779663,
0.23074182868003845,
-0.44178542494773865,
0.015828410163521767,
0.23098339140415192,
-0.29031214118003845,
-0.8813993334770203,
-0.4294462502002716,
0.0019060398917645216,
-0.22901825606822968,
0.06802276521921158,
0.3897484242916107,
-0.14567868411540985,
0.4289235770702362,
-0.12515662610530853,
-0.9034829139709473,
-0.10177771002054214,
-0.03322172537446022,
0.4616636037826538,
-0.6010392308235168,
-0.25494226813316345,
0.05829424783587456,
-0.00011736835585907102,
-0.440811425447464,
-0.04451705887913704,
-0.22766385972499847,
0.22661012411117554,
0.29287222027778625,
-0.23830591142177582,
-0.192956805229187,
-0.04699419066309929,
0.13577766716480255,
-0.09617099165916443,
-0.24548189342021942,
-0.4143223762512207,
-0.3189241290092468,
0.35994043946266174,
0.3092714548110962,
-0.2305159568786621,
0.07321067899465561,
0.14753180742263794,
-0.1485380381345749,
0.32270416617393494,
0.2314455658197403,
0.4056187570095062,
0.32964956760406494,
0.2732926309108734,
0.06074269488453865,
-0.03618250787258148,
0.5096592307090759,
-0.2065591961145401,
-0.17037443816661835,
-0.443676233291626,
-0.3421070873737335,
0.3582189977169037,
-0.018533192574977875,
0.3084877133369446,
-0.23740540444850922,
0.11779145151376724,
-0.32190924882888794,
0.004688846878707409,
-0.18865619599819183,
-0.15144824981689453,
-0.17510421574115753,
-0.49449431896209717,
-0.13517825305461884,
0.27173757553100586,
0.3142578601837158,
0.30769336223602295,
0.3107886016368866,
0.37887123227119446,
-0.29356807470321655,
-0.12693524360656738,
0.6766323447227478,
0.16962336003780365,
-0.46301066875457764,
0.4565492570400238,
-0.09582477807998657,
0.23878201842308044,
0.5060648322105408,
-0.48116087913513184,
0.1762794852256775,
0.49597442150115967,
0.16940782964229584,
0.43555402755737305,
0.5724746584892273,
-0.36850351095199585,
0.06737928092479706,
-0.23607751727104187,
-0.4622451663017273,
0.8999950885772705,
0.09295029938220978,
0.22299546003341675,
0.4437335729598999,
0.7096170783042908,
-0.17873765528202057,
-0.4758395254611969,
0.4760285019874573,
-0.29231444001197815,
0.4890250265598297,
-0.0018497152486816049,
0.232260063290596,
0.7062196135520935,
0.9000182151794434,
-0.3809829354286194,
0.20023421943187714,
0.1292235106229782,
0.1598762422800064,
0.22241811454296112,
-0.38709554076194763,
-0.21283893287181854,
0.08977794647216797,
1.3082886934280396,
0.17775090038776398,
-0.18488788604736328,
-0.19692298769950867,
-0.011212854646146297,
0.24479131400585175,
-0.21665842831134796,
0.018428537994623184,
0.040416449308395386,
0.20428864657878876,
-0.011816810816526413,
-0.2971023917198181,
-0.013843633234500885,
0.10878781974315643,
0.0709858313202858,
0.02667035162448883,
-0.06269653141498566,
-0.445088267326355,
-0.04188072308897972,
0.07651989907026291,
0.16208265721797943,
0.4238477349281311,
-0.3352169692516327,
0.16715241968631744,
-0.09875132143497467,
-0.07843486219644547,
0.3847741186618805,
0.49946755170822144,
0.010572085157036781,
-0.616642951965332,
0.03024452179670334,
-0.3480907678604126,
-0.16190603375434875,
0.02046898938715458,
0.05739705637097359,
-0.17629770934581757,
-0.03971968963742256,
0.03730210289359093,
-0.21138329803943634,
0.2512509822845459,
-0.3788577616214752,
-0.13032351434230804,
0.24089035391807556,
-0.28434935212135315,
0.1851753145456314,
-0.09548647701740265,
0.04508831351995468,
0.09420757740736008,
0.3608655333518982,
0.338367760181427,
0.51594477891922,
-0.6510906219482422,
0.2216302752494812,
0.31588149070739746,
-0.453279584646225,
0.031771402806043625,
-0.21839579939842224,
0.5652539730072021,
0.25576356053352356,
0.262497216463089,
-0.3476150929927826,
-0.19326627254486084,
-0.3283028304576874,
0.3087259829044342,
0.06185464933514595,
0.26445141434669495,
-0.6266041398048401,
-0.2768860459327698,
-0.5322585105895996,
0.05889524146914482,
0.4211634397506714,
-0.1256740391254425,
-0.3387756049633026,
0.10371110588312149,
-0.3424970805644989,
0.20115014910697937,
0.41613438725471497,
-0.004946419503539801,
-0.06218176707625389,
-0.45709046721458435,
-0.18416264653205872,
-0.632026731967926,
0.5190578699111938,
-0.09844619035720825,
-0.18913330137729645,
-0.1551467776298523,
0.03343789279460907,
0.34569844603538513,
-0.21556945145130157,
0.5889331102371216,
-0.49329671263694763,
0.21105101704597473,
-0.46040576696395874,
0.4670930802822113,
-0.5805739760398865,
0.299080491065979,
0.39640986919403076,
0.09009692817926407,
0.258475661277771,
-0.05988683924078941,
-0.2709358036518097,
-0.33621230721473694,
0.46626582741737366,
0.5151033997535706,
-0.013718402944505215,
0.18457724153995514,
0.2090531587600708,
-0.11419820040464401,
-0.7865638732910156,
0.18281042575836182,
-0.2434195876121521,
0.017853805795311928,
-0.15610553324222565,
-0.016199612990021706,
-0.5460905432701111,
0.03848014399409294,
0.03393739461898804,
-0.7689801454544067,
-0.03422623872756958,
0.010837211273610592
] |
We investigated the capacity of internal border control to limit influenza spread in an emergent pandemic in the context of Australia, a country with a low-population density and geopolitical boundaries that may facilitate restrictions. Mathematical models were used to study the time delay between epidemics in 2 population centers when travel restrictions were imposed. The models demonstrated that population size, travel rates, and places where travelers reside can strongly influence delay. The model simulations suggested that moderate delays in geographic spread may be possible with stringent restrictions and a low reproduction number, but results will be sensitive to the reproduction number and timing of restrictions. Model limitations include the absence of further importations and additional control measures. Internal border control may have a role in protecting domestic centers early in a pandemic, when importations are sparse. Our results may be useful for policymakers. | [
-0.00902794860303402,
0.021175876259803772,
-0.004141343291848898,
0.01811269298195839,
0.0328856036067009,
-0.02828350104391575,
0.009888224303722382,
-0.002304808469489217,
-0.012873897328972816,
-0.04031020402908325,
-0.005865502171218395,
0.01735772378742695,
0.003018247429281473,
0.013153396546840668,
-0.0038655963726341724,
0.018100768327713013,
0.0010546003468334675,
-0.003116556443274021,
0.008949613198637962,
-0.00347884907387197,
-0.015573020093142986,
0.0211468692868948,
0.011230278760194778,
0.00809241458773613,
-0.0013997810892760754,
0.01310877874493599,
0.0012648492120206356,
-0.03613042086362839,
0.023857679218053818,
-0.01717425137758255,
-0.017444685101509094,
0.027612846344709396,
0.016716770827770233,
0.006088935770094395,
0.006330873351544142,
-0.012085601687431335,
-0.003509256523102522,
0.027777932584285736,
-0.03611189126968384,
-0.004149893298745155,
0.022367993369698524,
-0.01046702079474926,
0.0022652731277048588,
-0.02495947852730751,
-0.007412496488541365,
-0.00731156300753355,
-0.006491959095001221,
-0.007764516863971949,
-0.03579241782426834,
0.008324271067976952,
-0.011961524374783039,
-0.02305624634027481,
-0.0068384879268705845,
-0.006387778557837009,
-0.006554346531629562,
-0.021445389837026596,
0.018950676545500755,
0.003388749435544014,
-0.03126511722803116,
0.03913762420415878,
0.006163519341498613,
0.006780295167118311,
0.00031114136800169945,
-0.027739739045500755,
0.005888053681701422,
-0.06706348806619644,
-0.027874287217855453,
0.013876695185899734,
0.014114206656813622,
-0.004127345513552427,
-0.006145039107650518,
0.006698910612612963,
-0.03759998083114624,
0.012713862583041191,
-0.015203996561467648,
0.000054257456213235855,
-0.019074352458119392,
0.025252293795347214,
0.0012141484767198563,
0.01332599762827158,
-0.017348142340779305,
0.0025274332147091627,
0.0038944967091083527,
0.02548312395811081,
-0.007157341111451387,
0.01573130115866661,
-0.0018798185046762228,
0.02333560585975647,
-0.0024806209839880466,
0.02897665835916996,
0.013304227963089943,
-0.009609262458980083,
-0.00570704834535718,
0.00957523100078106,
-0.030265895649790764,
-0.004313923884183168,
-0.02401195839047432,
-0.02009952813386917,
-0.0037274444475769997,
-0.018264194950461388,
0.003044393379241228,
0.010530048049986362,
0.017288148403167725,
0.016499919816851616,
-0.020326245576143265,
0.011842171661555767,
-0.02625693380832672,
0.028323568403720856,
-0.013016719371080399,
0.003215903416275978,
-0.006235897541046143,
-0.021085981279611588,
-0.011507492512464523,
0.0178883858025074,
0.010875267907977104,
-0.021671704947948456,
0.007499460130929947,
0.04091903194785118,
0.007719429209828377,
0.03253636509180069,
-0.002684873528778553,
0.006007953081279993,
-0.0020274256821721792,
-0.004283545538783073,
0.0020538612734526396,
0.01889645680785179,
0.012458635494112968,
-0.00404111435636878,
0.0008117468096315861,
-0.005692603997886181,
-0.008921612985432148,
-0.0018400636035948992,
0.012276198714971542,
0.001308269565925002,
-0.003564298152923584,
0.003741117659956217,
0.012120126746594906,
0.014574890956282616,
0.005709174554795027,
-0.010558009147644043,
-0.01595330610871315,
0.013823610730469227,
-0.006581099703907967,
0.012838633731007576,
0.027030758559703827,
-0.004339457023888826,
-0.013074008747935295,
0.014852259308099747,
0.021649863570928574,
0.014188254252076149,
0.011060060933232307,
-0.006692475639283657,
0.006360375788062811,
-0.015265624970197678,
-0.003298165975138545,
0.009667220525443554,
-0.009710460901260376,
-0.02937936782836914,
0.004487232770770788,
0.018005305901169777,
-0.016338255256414413,
0.006371804513037205,
-0.001842727418988943,
0.008603572845458984,
0.016626380383968353,
0.018719123676419258,
0.005076517350971699,
-0.008008221164345741,
-0.0017588824266567826,
0.006354819517582655,
-0.007549230940639973,
-0.0011181824374943972,
-0.01260400377213955,
0.011923935264348984,
0.0037120277993381023,
-0.0081257289275527,
0.003141497727483511,
0.008792076259851456,
-0.00017127650789916515,
0.06679637730121613,
-0.005953441374003887,
-0.014786779880523682,
-0.01021624356508255,
-0.01158780138939619,
0.002629182767122984,
-0.009294169023633003,
0.034133993089199066,
-0.012143727391958237,
-0.007595705799758434,
-0.0033487817272543907,
-0.013989092782139778,
0.0029277349822223186,
-0.0027307001873850822,
-0.010044296272099018,
-0.013217017985880375,
0.00339761795476079,
-0.0028644800186157227,
0.001333237742073834,
0.0007605768041685224,
0.003577224910259247,
0.007492825388908386,
0.0007996545173227787,
0.04655388742685318,
0.012213647365570068,
0.00599896814674139,
0.01548745483160019,
0.013033276423811913,
-0.02015063911676407,
0.02019112929701805,
-0.012748997658491135,
0.006462639197707176,
-0.008356006816029549,
0.0017450519371777773,
-0.0060244533233344555,
-0.041312675923109055,
-0.0006428718334063888,
0.010192529298365116,
-0.002449603984132409,
0.02442489191889763,
-0.012407153844833374,
-0.0022292339708656073,
0.01238353829830885,
-0.013194840401411057,
-0.006655810866504908,
0.02029905654489994,
-0.007591109722852707,
-0.009215492755174637,
0.011042645201086998,
-0.0008797862101346254,
0.006559725850820541,
-0.00619661808013916,
-0.0353473424911499,
-0.010434133931994438,
0.006332396529614925,
0.0034552766010165215,
-0.013332072645425797,
0.01320381835103035,
-0.0197908915579319,
0.014095740392804146,
-0.008900988847017288,
-0.008321935310959816,
-0.01132851094007492,
0.00424420740455389,
0.0004194425418972969,
0.029582524672150612,
-0.01296449825167656,
0.03506385162472725,
-0.004890138749033213,
-0.02071417309343815,
-0.0026246397756040096,
0.007211888208985329,
0.010052600875496864,
-0.006842400878667831,
0.000541539047844708,
0.03869616612792015,
-0.022186368703842163,
-0.0069547388702631,
-0.003128343028947711,
0.023006008937954903,
-0.015413676388561726,
0.008184119127690792,
0.008438300341367722,
-0.025139229372143745,
-0.012071041390299797,
0.0027207029052078724,
0.027711793780326843,
0.0009898090502247214,
0.018175050616264343,
0.007042593322694302,
0.018667787313461304,
0.0002025446156039834,
-0.012865724042057991,
0.0003607305698096752,
-0.08123978227376938,
-0.018280405551195145,
0.008050259202718735,
-0.005613313987851143,
0.010064378380775452,
-0.01302915159612894,
0.007134545594453812,
0.013921406120061874,
-0.005722134839743376,
0.00565785076469183,
0.009202846325933933,
0.002154106739908457,
-0.00985383614897728,
0.00015707616694271564,
0.007394278421998024,
-0.012831613421440125,
0.007793038617819548,
0.04217395558953285,
-0.0010985718108713627,
-0.010905236937105656,
-0.0005274759605526924,
-0.013684066943824291,
0.02942270040512085,
-0.009224766865372658,
0.005714466795325279,
0.0016265353187918663,
0.035683728754520416,
0.00497673824429512,
-0.008305388502776623,
0.010444199666380882,
0.0023350361734628677,
-0.024591080844402313,
-0.008328255265951157,
-0.024744637310504913,
0.016241230070590973,
-0.00375754595734179,
0.004625663626939058,
-0.018873121589422226,
-0.004101093392819166,
0.010655872523784637,
0.021848704665899277,
0.019627423956990242,
0.0004440648481249809,
0.02091386169195175,
0.005553028546273708,
0.004200478084385395,
0.0206772293895483,
-0.030288182199001312,
0.02015923708677292,
0.016837870702147484,
-0.004129950422793627,
-0.011340797878801823,
0.019818522036075592,
0.01617751270532608,
-0.006813704036176205,
-0.010368600487709045,
-0.02414146065711975,
-0.01743902824819088,
-0.011656124144792557,
-0.009829355403780937,
-0.01597818359732628,
0.002340741455554962,
0.006293315440416336,
0.006959239020943642,
-0.03032444417476654,
-0.03216096758842468,
0.01642642728984356,
0.00896461308002472,
-0.013730084523558617,
0.00868177693337202,
0.022746745496988297,
-0.01223741751164198,
0.02145043946802616,
-0.010309882462024689,
-0.007456242106854916,
-0.013899262994527817,
-0.014919338747859001,
-0.012142892926931381,
0.04849734157323837,
-0.0007804501801729202,
-0.023334795609116554,
0.011798429302871227,
-0.018705053254961967,
-0.005024932324886322,
-0.02678404375910759,
-0.01516440138220787,
0.009315643459558487,
-0.015028957277536392,
0.014788228087127209,
-0.011282360181212425,
0.05505409836769104,
0.016440778970718384,
-0.004566444084048271,
0.004785423632711172,
-0.007895802147686481,
0.004358960315585136,
0.007911363616585732,
0.0021540799643844366,
0.005401378497481346,
0.011058902367949486,
0.029261000454425812,
-0.0030961516313254833,
-0.0010567461140453815,
-0.014033917337656021,
-0.028964050114154816,
0.01689099334180355,
0.009246814996004105,
0.005771677941083908,
-0.013410896994173527,
-0.007289730943739414,
-0.030967317521572113,
0.0026061534881591797,
-0.005345472600311041,
0.013635439798235893,
0.013507308438420296,
0.016153525561094284,
0.02746105194091797,
0.010714050382375717,
0.07224409282207489,
-0.01744725927710533,
0.012796927243471146,
-0.012094222009181976,
0.012647086754441261,
-0.013742020353674889,
-0.02005951851606369,
-0.01147603988647461,
0.01864546537399292,
-0.025520101189613342,
0.01142535824328661,
0.0037778294645249844,
0.03742660582065582,
-0.016733461990952492,
-0.022187035530805588,
-0.002377710770815611,
0.0077232676558196545,
-0.007203546818345785,
0.013588729314506054,
-0.0041701821610331535,
0.00452428450807929,
-0.003297155722975731,
0.005494251847267151,
-0.003200659528374672,
0.011543629691004753,
-0.008361201733350754,
0.019459445029497147,
-0.015433579683303833,
0.0032440111972391605,
0.00009356637019664049,
0.031176459044218063,
-0.00038646673783659935,
-0.003184274770319462,
0.000009322306141257286,
0.02513105794787407,
-0.004147413186728954,
-0.023079343140125275,
0.012205099686980247,
0.006940780207514763,
0.0032002143561840057,
0.0226743146777153,
-0.012343296781182289,
0.015714190900325775,
0.019198134541511536,
-0.031799621880054474,
0.019741801545023918,
-0.0042846594005823135,
-0.008560096845030785,
-0.013220824301242828,
0.011085430160164833,
-0.005659183487296104,
0.029089845716953278,
0.016870420426130295,
0.028224952518939972,
0.01092064380645752,
0.0017906306311488152,
-0.015211379155516624,
0.006282291375100613,
0.0030787079595029354,
0.03192086145281792,
-0.0026935781352221966,
-0.013616186566650867,
0.027820372954010963,
-0.01612924039363861,
0.010920751839876175,
-0.017877060920000076,
-0.007893924601376057,
0.002301013795658946,
-0.016369441524147987,
0.011240432038903236,
0.023729294538497925,
-0.015534366481006145,
-0.002810970414429903,
0.0015959152951836586,
-0.028976822271943092,
-0.0024541588500142097,
-0.04708101972937584,
0.0005724122747778893,
-0.008482692763209343,
-0.00883133988827467,
0.011093263514339924,
-0.00018972065299749374,
0.01654820144176483,
-0.003241451922804117,
-0.003946290351450443,
-0.020927654579281807,
-0.0006649827118963003,
-0.07422400265932083,
-0.006308397278189659,
0.021530956029891968,
-0.009782195091247559,
0.03199822083115578,
-0.00024845957523211837,
-0.008435571566224098,
0.010039318352937698,
0.004679146222770214,
-0.011148544028401375,
-0.004441673401743174,
0.002481034491211176,
0.003623710013926029,
-0.006314517930150032,
0.014677634462714195,
0.012223929166793823,
-0.024136357009410858,
0.00718149496242404,
-0.005902310833334923,
0.01156670693308115,
0.011506494134664536,
0.02490963786840439,
-0.02506817691028118,
-0.014919618144631386,
0.016011733561754227,
-0.0809999480843544,
-0.01361772045493126,
0.011289549991488457,
-0.005287971347570419,
0.00400831364095211,
0.006999732460826635,
0.006504693999886513,
-0.0175384059548378,
-0.02460065297782421,
-0.014175504446029663,
0.006719750352203846,
-0.00767657533288002,
-0.000023343367502093315,
-0.012687573209404945,
0.014481285586953163,
-0.0028036762960255146,
0.013760088942945004,
-0.02084478735923767,
-0.005812081973999739,
-0.013021030463278294,
0.020908478647470474,
0.003533846465870738,
-0.007330002263188362,
-0.001021057367324829,
-0.009125590324401855,
-0.015921786427497864,
-0.004284096881747246,
0.005748956464231014,
0.025512754917144775,
-0.00013517856132239103,
-0.006602821871638298,
0.003914023749530315,
0.011121101677417755,
-0.014538288116455078,
0.00101697095669806,
-0.019674059003591537,
0.03144000470638275,
-0.0040608737617731094,
0.01131225936114788,
-0.003231119131669402,
-0.007718643173575401,
0.01740766502916813,
0.0034310342743992805,
-0.0013093599118292332,
0.0013790382072329521,
0.014012041501700878,
0.008623247034847736,
-0.006666990928351879,
0.025118635967373848,
0.004088541492819786,
0.011899217031896114,
-0.02962387725710869,
0.02167976275086403,
-0.004180447664111853,
0.013840756379067898,
0.0011266100918874145,
-0.010330881923437119,
0.003595144720748067,
0.02960982546210289,
0.017737343907356262,
0.0006453517125919461,
0.010403076186776161,
-0.0021969634108245373,
0.0718006044626236,
-0.023541219532489777,
0.02532556839287281,
0.00241951085627079,
-0.007970841601490974,
-0.0012964969500899315,
-0.018001660704612732,
-0.005741886328905821,
-0.018516499549150467,
-0.02110045775771141,
0.03519602119922638,
0.0022314030211418867,
-0.0061288634315133095,
0.011775914579629898,
-0.004832675214856863,
0.008886120282113552,
0.015678979456424713,
-0.0037108645774424076,
0.012470304034650326,
0.008952144533395767,
-0.0221692007035017,
-0.01507064700126648,
-0.019762631505727768,
0.011195605620741844,
0.010180100798606873,
0.011819470673799515,
-0.01811748370528221,
0.013169271871447563,
-0.024505291134119034,
0.013719277456402779,
-0.014269826002418995,
-0.0009856721153482795,
0.0052618347108364105,
-0.015855412930250168,
0.02796839363873005,
-0.0019161852542310953,
0.01367199793457985,
0.0002764610107988119,
-0.0012027020566165447,
0.0012519017327576876,
-0.018163755536079407,
-0.021937794983386993,
0.009878383949398994,
-0.011454571969807148,
-0.011231476441025734,
0.015413941815495491,
0.0066693611443042755,
0.0027850887272506952,
0.011564533226191998,
0.0102042555809021,
-0.01937282644212246,
-0.004317475948482752,
0.017597783356904984,
0.007653913460671902,
-0.017120106145739555,
-0.013061518780887127,
-0.013873761519789696,
0.015919093042612076,
0.008772406727075577,
0.01160648837685585,
-0.01917910948395729,
-0.00944134034216404,
0.004425651393830776,
-0.006766538135707378,
-0.006849480327218771,
0.0030429873149842024,
-0.004355737008154392,
-0.0070088645443320274,
0.007164677605032921,
0.010311201214790344,
-0.010868173092603683,
0.017142459750175476,
0.006593711674213409,
-0.007863583043217659,
0.015020058490335941,
0.004098528530448675,
0.018534310162067413,
0.012787269428372383,
0.006310251075774431,
0.02644810639321804,
-0.019092418253421783,
-0.02780875749886036,
0.0029298760928213596,
-0.028120871633291245,
-0.0031557204201817513,
-0.001976578962057829,
0.0009495317935943604,
0.008548351936042309,
-0.00912263710051775,
0.006509639322757721,
0.00025733280926942825,
-0.001414744183421135,
0.0017803778173401952,
0.01969698816537857,
0.009843306615948677,
0.033763300627470016,
0.0061431583017110825,
0.005040675867348909,
0.03819175437092781,
0.009917126968502998,
0.011591129004955292,
0.03038613311946392,
0.010920950211584568,
-0.020216986536979675,
-0.02155623584985733,
-0.005169237032532692,
0.004843255039304495,
0.005079751368612051,
-0.002512813312932849,
-0.002739730291068554,
0.017562400549650192,
0.0008521538693457842,
0.01822505332529545,
0.0026101190596818924,
0.001192334108054638,
-0.0022864588536322117,
-0.014386778697371483,
0.009820675477385521,
0.03442111238837242,
-0.005007457919418812,
0.01999102532863617,
0.002132166177034378,
-0.00501633808016777,
-0.006291812751442194,
-0.0017514690989628434,
-0.021098334342241287,
-0.012686265632510185,
0.009626934304833412,
-0.003670509671792388,
0.004588346928358078,
0.0030027509201318026,
-0.003703438676893711,
-0.0032914052717387676,
0.013543347828090191,
-0.00003092130646109581,
0.014494838193058968,
0.011891795322299004,
0.0053220586851239204,
0.007171990349888802,
0.0060519203543663025,
0.016138114035129547,
-0.011359027586877346,
0.007886184379458427,
0.007120140362530947,
0.007435666397213936,
0.0006921486929059029,
0.01734653301537037,
0.0012609055265784264,
0.01723271980881691,
0.0036711874417960644,
-0.004521362483501434,
0.008495555259287357,
0.02338113635778427,
-0.006290934979915619,
0.013767238706350327,
0.004600301384925842,
0.0052270847372710705,
-0.018663816154003143,
-0.010551853105425835,
-0.00552706653252244,
0.005004500970244408,
0.00011248118244111538,
-0.003506115637719631,
0.014434163458645344,
0.007897371426224709,
-0.00853012129664421,
0.021478980779647827,
0.02682766318321228,
-0.005551949609071016,
0.010138462297618389,
-0.01970883645117283,
-0.018848305568099022,
-0.010058971121907234,
0.017000781372189522,
-0.011812928132712841,
-0.013924145139753819,
0.012568417936563492,
0.015910930931568146,
-0.022538691759109497,
0.011312389746308327,
0.029271762818098068,
-0.025186430662870407,
0.011679433286190033,
-0.00764091033488512,
-0.006318445783108473,
0.008790647611021996,
-0.01023908331990242,
-0.003858954180032015,
0.01745954528450966,
-0.007032434921711683,
0.0010892683640122414,
-0.005437925923615694,
-0.018620898947119713,
0.00495267054066062,
-0.009655077010393143,
-0.0009101978503167629,
-0.009545101784169674,
-0.024739068001508713,
0.012060627341270447,
0.028299672529101372,
0.010164383798837662,
0.0043151541613042355
] | [
0.47980862855911255,
-0.2562198042869568,
-0.18666912615299225,
0.2540559470653534,
0.3265560567378998,
0.3688727021217346,
0.34936973452568054,
-0.269629567861557,
-0.4260929226875305,
-0.5164299011230469,
0.1665782779455185,
-0.2952249348163605,
-0.15313281118869781,
0.312368243932724,
0.2504626214504242,
0.3827458322048187,
0.2448744773864746,
0.29530155658721924,
-0.18408474326133728,
-0.5542945861816406,
-0.28856414556503296,
-0.4002431035041809,
0.319021999835968,
0.015282575972378254,
0.2878796458244324,
-0.4935416877269745,
0.46524667739868164,
0.0619877390563488,
-0.03222568333148956,
-0.011888480745255947,
0.129136323928833,
0.5651729702949524,
-0.5843311548233032,
-0.13371072709560394,
-0.11310043185949326,
-0.08445415645837784,
0.0901729017496109,
-0.00511756120249629,
-0.3048606514930725,
-0.44038844108581543,
-0.1345798373222351,
0.11065948754549026,
-0.44924837350845337,
0.30537086725234985,
0.1291533261537552,
-0.80037921667099,
-1.2540448904037476,
-0.010882880538702011,
0.20555028319358826,
-0.4021124541759491,
-0.2097369283437729,
0.2870478332042694,
0.48527467250823975,
0.07725642621517181,
0.2033807933330536,
0.19629357755184174,
-0.4335564970970154,
-0.25754863023757935,
0.15074944496154785,
-0.4905603229999542,
0.2556616961956024,
-0.009404333308339119,
-0.2327796220779419,
0.15323859453201294,
-0.17880642414093018,
0.415912926197052,
0.3969631493091583,
-0.01666916161775589,
0.3633880615234375,
-0.18177373707294464,
-0.15850746631622314,
-0.2947334349155426,
-0.2342662662267685,
0.0749102532863617,
-0.23384259641170502,
0.10485973209142685,
0.10215359926223755,
-0.3506765365600586,
0.037785809487104416,
0.33362728357315063,
-0.16953600943088531,
0.09252532571554184,
0.41816362738609314,
-0.9439061880111694,
1.0311434268951416,
-0.10663869231939316,
-0.15612222254276276,
0.2412865161895752,
-0.3436393439769745,
-0.07343760877847672,
-0.1610373705625534,
-0.060493919998407364,
0.08256113529205322,
0.435939222574234,
0.26721033453941345,
0.07375755161046982,
0.2635117769241333,
0.07187270373106003,
-0.0359487421810627,
0.6172833442687988,
-0.1837005615234375,
-0.11499351263046265,
0.06646383553743362,
-0.11017138510942459,
-0.11109404265880585,
-0.9141701459884644,
-0.2997296154499054,
0.033626072108745575,
-0.42659464478492737,
0.04031679779291153,
-0.06284025311470032,
0.017683502286672592,
0.016728593036532402,
-0.48975732922554016,
-0.04798012599349022,
-0.010823815129697323,
0.42349088191986084,
-0.3209494948387146,
0.336093008518219,
0.25366881489753723,
-0.05892574042081833,
1.1691699028015137,
-0.286856085062027,
0.23726168274879456,
-0.12018191814422607,
-0.18573050200939178,
0.7346438765525818,
-0.3459426760673523,
-0.618529736995697,
0.4672132134437561,
-0.09332167357206345,
0.6944524049758911,
-0.4227718114852905,
-0.11479395627975464,
-0.3180837333202362,
-0.16496235132217407,
-0.4315655827522278,
0.7344598174095154,
0.19265158474445343,
-0.1820618063211441,
-0.20706294476985931,
-0.7318985462188721,
-0.33311381936073303,
0.12078282237052917,
0.11434280872344971,
-0.0470455177128315,
-0.16036736965179443,
-0.2510557770729065,
-0.06404805183410645,
-0.19223040342330933,
-0.08679301291704178,
0.25571388006210327,
-0.6978644132614136,
0.3274906277656555,
-0.31278449296951294,
0.2729743719100952,
-0.21874043345451355,
-0.03136638551950455,
-0.04338257759809494,
-0.08719348162412643,
0.30388572812080383,
0.28273481130599976,
-0.31663158535957336,
-0.12283314764499664,
0.25071293115615845,
-0.034791890531778336,
-0.15933957695960999,
0.4055522680282593,
-0.013138663955032825,
-0.29240038990974426,
-0.4259643852710724,
0.13657857477664948,
0.09086279571056366,
-0.637010931968689,
-0.29365402460098267,
-0.03295144438743591,
0.4113813042640686,
0.3768535554409027,
0.20896534621715546,
0.2582305669784546,
-0.5823825001716614,
-0.20044583082199097,
-0.17814797163009644,
-0.23304781317710876,
0.32383862137794495,
0.054198008030653,
0.37399423122406006,
-0.09390480071306229,
-0.5024735331535339,
-0.3990802466869354,
-0.0325949527323246,
-0.4638380706310272,
0.6352496147155762,
-0.7433873414993286,
0.8001019358634949,
-0.3088575303554535,
0.14498816430568695,
1.729364037513733,
-0.019708188250660896,
0.19116151332855225,
0.2537519931793213,
0.08872213959693909,
0.5912519097328186,
0.013300646096467972,
-0.5943064093589783,
0.29684755206108093,
0.03760434687137604,
0.05971386283636093,
-0.5412383675575256,
0.36243942379951477,
0.6905929446220398,
-0.4403061270713806,
-0.26330989599227905,
-0.4016430974006653,
0.025826798751950264,
0.2286364734172821,
-0.011551525443792343,
-0.07442986965179443,
-0.15885090827941895,
0.014674332924187183,
0.6222974061965942,
-0.18777351081371307,
0.5102599263191223,
0.5394604206085205,
0.03681101277470589,
0.01450399775058031,
0.34523260593414307,
0.3929358720779419,
0.6997849941253662,
-1.1189643144607544,
-0.10711076110601425,
-0.4672459661960602,
0.3785560131072998,
-0.7553282380104065,
-0.01969072036445141,
0.27845096588134766,
0.04592875763773918,
-0.10070164501667023,
-0.2013717144727707,
0.2705622911453247,
-0.1843557357788086,
0.37214064598083496,
-0.20306724309921265,
0.8016767501831055,
-0.35906314849853516,
-0.3122527301311493,
0.07066958397626877,
0.08491064608097076,
-0.5146664977073669,
0.008585222996771336,
0.6740880012512207,
0.41436105966567993,
0.17172464728355408,
-0.41100984811782837,
0.0815439447760582,
0.15021096169948578,
-0.16039837896823883,
-0.6217944025993347,
0.510153591632843,
-0.46578535437583923,
0.13189508020877838,
0.3354990482330322,
0.10155940800905228,
0.09743767976760864,
0.26005813479423523,
-0.6551508903503418,
-0.7304680943489075,
-0.5703544020652771,
0.20807743072509766,
0.7244597673416138,
0.6792740821838379,
-0.10299686342477798,
-0.5515857338905334,
0.012439649552106857,
0.34482935070991516,
-0.052973996847867966,
0.15724508464336395,
0.5355308651924133,
-0.28594645857810974,
0.20564348995685577,
0.09066257625818253,
0.40739569067955017,
0.5213523507118225,
-0.410722553730011,
-0.2637386918067932,
-0.276824414730072,
0.2423449009656906,
-0.24267388880252838,
-0.5435425043106079,
-0.2330881506204605,
-0.02850579097867012,
0.18268610537052155,
0.02211700938642025,
0.062257178127765656,
0.4006052613258362,
0.18465924263000488,
-0.4391579329967499,
0.32448992133140564,
0.9234581589698792,
-0.06657613068819046,
-0.3141322135925293,
0.27054500579833984,
-0.24199119210243225,
-0.042014870792627335,
-0.1726548820734024,
0.1558060497045517,
-0.717643141746521,
-0.17297230660915375,
-6.178356647491455,
-0.04749797657132149,
-0.22907540202140808,
-0.40232059359550476,
-0.7748998999595642,
0.13257808983325958,
0.9568026661872864,
-0.25164321064949036,
0.2571825683116913,
-0.2221430391073227,
0.7046726942062378,
0.44294416904449463,
0.08161237835884094,
0.11894091963768005,
0.35481253266334534,
0.3781491219997406,
0.14587187767028809,
-0.01764250546693802,
0.16802619397640228,
0.19803255796432495,
-0.24754126369953156,
-0.1724368929862976,
0.27901366353034973,
0.07369808107614517,
0.6968138813972473,
-0.16122303903102875,
-0.7721840143203735,
0.1540650576353073,
-0.10963792353868484,
-0.02754642441868782,
-0.0703379288315773,
-0.5674302577972412,
-0.1980307251214981,
-0.32120025157928467,
0.1274082064628601,
0.36420702934265137,
0.3290350139141083,
0.14557208120822906,
0.14281249046325684,
-0.09787020087242126,
-0.27468276023864746,
0.3324891924858093,
-0.01058324333280325,
0.06383635103702545,
-0.2956114709377289,
-0.2125214785337448,
0.08190292119979858,
-0.04182574152946472,
-0.13139478862285614,
0.783574640750885,
0.026954449713230133,
0.04388929903507233,
0.12355554103851318,
0.35646504163742065,
-0.31794050335884094,
0.013038954697549343,
0.04207778349518776,
-0.1215265691280365,
-0.7256431579589844,
0.283547967672348,
0.025736987590789795,
-0.5238511562347412,
0.24778208136558533,
-0.33500441908836365,
0.06241869553923607,
0.1658381223678589,
-0.44327428936958313,
-0.29619207978248596,
-0.12700976431369781,
-0.023828892037272453,
-0.2371976673603058,
-0.13467617332935333,
0.3700791597366333,
-0.7699739336967468,
0.04353608191013336,
-0.4189217984676361,
-0.05644618719816208,
0.22103415429592133,
0.2069767415523529,
-0.5815466046333313,
-0.3041529059410095,
0.30411699414253235,
0.2383926659822464,
-0.09579596668481827,
0.4143402576446533,
-0.1386374831199646,
0.07608085125684738,
-0.13536690175533295,
-0.23420913517475128,
-0.11658216267824173,
0.02873995527625084,
-0.6159263849258423,
0.24886280298233032,
-0.13161003589630127,
0.23170582950115204,
0.75859135389328,
0.2225436121225357,
0.05488179624080658,
0.212886244058609,
-0.438457727432251,
0.5350140929222107,
-0.003429547417908907,
-0.4627244472503662,
-0.9242278933525085,
0.02515813708305359,
0.350279301404953,
0.05645487457513809,
0.3743005692958832,
0.6087448596954346,
-0.4972800016403198,
0.050022490322589874,
0.23114179074764252,
0.0020857045892626047,
-0.06800549477338791,
0.028802700340747833,
-0.14112725853919983,
0.1849500983953476,
-0.06110968813300133,
0.5675302743911743,
-0.3640024960041046,
0.08183087408542633,
0.2143402248620987,
0.108005590736866,
0.8819961547851562,
0.26214221119880676,
-0.06016959995031357,
0.014699237421154976,
0.5622999668121338,
-0.3321387767791748,
0.019635509699583054,
0.21314986050128937,
0.46152979135513306,
-0.04766591638326645,
-0.10750532895326614,
-0.11696875840425491,
-0.5649672746658325,
-0.228239968419075,
0.09372766315937042,
0.5689020156860352,
-0.07524458318948746,
0.23255367577075958,
-0.1398148089647293,
-0.22718097269535065,
0.008823874406516552,
0.23086130619049072,
0.08445867151021957,
0.07593667507171631,
-0.10990405827760696,
-0.4511253535747528,
-0.35396313667297363,
-0.4614700973033905,
-0.2771741449832916,
0.15744565427303314,
-0.22614817321300507,
-0.3991697430610657,
-0.10185591876506805,
0.9700669050216675,
0.10798439383506775,
0.14164794981479645,
-0.5246650576591492,
0.6859422326087952,
-0.03965356573462486,
-0.9225530028343201,
0.085777148604393,
0.10931137949228287,
0.04766644537448883,
0.10092492401599884,
-0.2507283389568329,
-0.14740461111068726,
0.49798858165740967,
0.21082612872123718,
-0.4553649127483368,
-0.31627359986305237,
0.24510714411735535,
-0.016823820769786835,
-0.03561805933713913,
-0.6038146018981934,
-0.0956786498427391,
-0.19475264847278595,
0.3377436101436615,
-0.13419482111930847,
-0.22629614174365997,
-0.4026940166950226,
0.3020760416984558,
0.1546005755662918,
0.3392886519432068,
-0.19932325184345245,
-0.12439984083175659,
-0.330601304769516,
-0.3221510350704193,
0.01481652446091175,
0.4889094829559326,
0.06501449644565582,
-0.15375538170337677,
0.04748423397541046,
-0.38738805055618286,
0.05351574718952179,
0.026941394433379173,
-0.2891145348548889,
-0.14393512904644012,
0.43623924255371094,
0.4458320736885071,
-0.26626065373420715,
0.39485904574394226,
0.10708186030387878,
0.08856524527072906,
0.01481181476265192,
-0.2331705093383789,
0.20664116740226746,
-0.3732026219367981,
-0.32132139801979065,
-0.2661876082420349,
-0.24736441671848297,
0.7548158764839172,
-0.05896375700831413,
-0.08220375329256058,
0.08811632543802261,
-0.13244926929473877,
-0.13004447519779205,
0.3020493686199188,
0.13434885442256927,
-0.2644939720630646,
-0.333103209733963,
-0.34752771258354187,
-0.5277661085128784,
0.44101738929748535,
0.48445889353752136,
-1.1393070220947266,
-0.0867532417178154,
0.507451057434082,
-0.31864532828330994,
-0.268405556678772,
0.5442883968353271,
0.5942863821983337,
-0.5380957722663879,
-0.21790777146816254,
-0.1475822925567627,
-0.25216996669769287,
0.12737174332141876,
0.397895872592926,
0.06022350862622261,
0.716438889503479,
0.1304532289505005,
-0.4589158892631531,
-0.5548759698867798,
0.13925465941429138,
-0.10399826616048813,
-0.5922443866729736,
-0.6442807912826538,
-0.173824742436409,
-0.22569602727890015,
-0.39307278394699097,
0.2652365267276764,
0.08749419450759888,
0.3906145393848419,
0.42886117100715637,
0.010912721045315266,
0.10945986211299896,
0.07971343398094177,
0.09091697633266449,
0.12155400216579437,
-0.5257384181022644,
-0.1819285750389099,
-0.1807829886674881,
0.28998950123786926,
-0.19688519835472107,
0.008348452858626842,
-0.6901143193244934,
-0.07335851341485977,
-0.6361714601516724,
-0.00890035554766655,
0.037120237946510315,
0.6366215348243713,
0.014510400593280792,
0.49509042501449585,
-0.2204819619655609,
0.024349456652998924,
0.20155641436576843,
0.2260894626379013,
0.004844572860747576,
0.038306716829538345,
-0.5003452897071838,
0.13466735184192657,
-0.5745537281036377,
0.7161513566970825,
-0.3890027105808258,
0.026072027161717415,
-0.022920293733477592,
0.2403840571641922,
-0.5463259220123291,
0.09440989792346954,
0.032168515026569366,
-0.7588733434677124,
-0.11597099900245667,
-0.11053261905908585,
-0.04327508807182312,
0.3479737639427185,
0.1157267615199089,
-0.1590644121170044,
-0.4637649655342102,
-0.5429403185844421,
0.6641181707382202,
-0.17976625263690948,
-0.3860527575016022,
0.10527211427688599,
-0.1866782158613205,
0.3775785267353058,
0.20774148404598236,
0.007101905066519976,
0.2145739644765854,
0.4067438840866089,
0.09987134486436844,
0.4686432480812073,
0.5070511698722839,
-0.20289935171604156,
0.17419414222240448,
0.0991947278380394,
-0.32183700799942017,
0.4725108742713928,
-0.09318990260362625,
-0.09123040735721588,
0.6378853917121887,
0.2377401888370514,
-0.07160273939371109,
-0.33828917145729065,
0.5437300801277161,
-0.1025635302066803,
0.45015931129455566,
-0.12272918969392776,
0.4516226351261139,
0.20753999054431915,
0.6114388108253479,
-0.25315985083580017,
-0.03184425085783005,
0.3523085117340088,
0.3790656626224518,
0.2866761386394501,
-0.2587036192417145,
-0.490120530128479,
-0.08052482455968857,
0.6567937135696411,
0.2874169945716858,
-0.024815041571855545,
0.08818551898002625,
-0.02408754825592041,
0.3265821635723114,
0.1475944072008133,
0.4319436252117157,
-0.10109419375658035,
0.4611153304576874,
0.4684006869792938,
0.20747825503349304,
-0.13815847039222717,
0.4883319139480591,
-0.15659649670124054,
0.1014506071805954,
0.33663421869277954,
-0.18420007824897766,
-0.6947653293609619,
0.04295002296566963,
0.07926557958126068,
0.211523175239563,
-0.2012825757265091,
0.13263185322284698,
0.27641257643699646,
-0.0638267919421196,
0.7944532632827759,
0.06838878244161606,
0.032676246017217636,
-0.33529430627822876,
0.046718403697013855,
-0.19773730635643005,
-0.3788684606552124,
0.19821299612522125,
0.14773745834827423,
-0.7167282104492188,
-0.11854494363069534,
-0.2552052438259125,
0.10431134700775146,
0.34946972131729126,
0.18750448524951935,
-0.15564458072185516,
0.44811391830444336,
-0.6649381518363953,
0.03002120740711689,
-0.2281126230955124,
-0.33090147376060486,
0.310166597366333,
0.059022970497608185,
-0.03341808542609215,
0.030499659478664398,
-0.44697144627571106,
-0.5278757214546204,
0.28898894786834717,
-0.13208842277526855,
-0.46218299865722656,
-0.1659955531358719,
0.6486728191375732,
0.17990684509277344,
-0.13899238407611847,
0.3238823115825653,
-0.33667245507240295,
-0.5007622838020325,
0.4333372712135315,
-0.10606010258197784,
0.49490663409233093,
-0.3122098743915558,
-0.06181289628148079,
-0.435413658618927,
0.15378136932849884,
0.7504133582115173,
0.131890669465065,
-0.5696814656257629,
0.04939207434654236,
-0.059448592364788055,
0.4712035357952118,
0.3131750524044037,
-0.33070358633995056,
-0.11961088329553604,
-0.7855689525604248,
-0.10908710956573486,
-0.6270084381103516,
0.4181998074054718,
-0.23014067113399506,
0.36953699588775635,
-0.10261513292789459,
0.3784796893596649,
0.410290002822876,
0.04848024621605873,
0.7281781435012817,
0.09092380851507187,
-0.44604551792144775,
-0.5860536098480225,
0.34519433975219727,
-0.43241986632347107,
0.23263002932071686,
0.05109968036413193,
0.3361032009124756,
0.5960595011711121,
0.1907985806465149,
0.1856600046157837,
-0.18618854880332947,
0.3088367283344269,
0.3009478449821472,
0.3477689027786255,
0.124379962682724,
-0.11098168045282364,
-0.32843175530433655,
-0.5605360865592957,
0.485074907541275,
-0.08109898120164871,
-0.06529264897108078,
-0.22822155058383942,
-0.05438465252518654,
-0.01069293450564146,
0.1307111531496048,
-0.01483692042529583,
-0.4185178577899933,
-0.307152658700943,
-0.4336561858654022
] |
INTRODUCTION: Extracorporeal Life Support (ECLS) and extracorporeal membrane oxygenation (ECMO) have been indicated as treatment for acute respiratory and/or cardiac failure. Here we describe our first year experience of in-hospital ECLS activity, the operative algorithm and the protocol for centralization of adult patients from district hospitals. METHODS: At a tertiary referral trauma center (Careggi Teaching Hospital, Florence, Italy), an ECLS program was developed from 2008 by the Emergency Department and Heart and Vessel Department ICUs. The ECLS team consists of an intensivist, a cardiac surgeon, a cardiologist and a perfusionist, all trained in ECLS technique. ECMO support was applied in case of severe acute respiratory distress syndrome (ARDS) not responsive to conventional treatments. The use of veno-arterial (V-A) ECLS for cardiac support was reserved for cases of cardiac shock refractory to standard treatment and cardiac arrests not responding to conventional resuscitation. RESULTS: A total of 21 patients were treated with ECLS during the first year of activity. Among them, 13 received ECMO for ARDS (5 H1N1-virus related), with a 62% survival. In one case of post-traumatic ARDS, V-A ECLS support permitted multiple organ donation after cerebral death was confirmed. Patients treated with V-A ECLS due to cardiogenic shock (N = 4) had a survival rate of 50%. No patients on V-A ECLS support after cardiac arrest survived (N = 4). CONCLUSIONS: In our centre, an ECLS Service was instituted over a relatively limited period of time. A strict collaboration between different specialists can be regarded as a key feature to efficiently implement the process. | [
0.010152195580303669,
0.004731625318527222,
-0.017431341111660004,
0.007727138698101044,
-0.021969422698020935,
-0.007867877371609211,
0.008303139358758926,
0.013625724241137505,
-0.009834221564233303,
-0.009180014953017235,
-0.02186112478375435,
0.015782136470079422,
0.029842831194400787,
0.027162156999111176,
0.026749789714813232,
0.010249684564769268,
-0.0014807109255343676,
0.04319518059492111,
0.018403444439172745,
0.011782891117036343,
0.006008341908454895,
0.005931353196501732,
0.007418444845825434,
0.005002089310437441,
0.03096006065607071,
0.009776045568287373,
0.025066670030355453,
-0.0006133030401542783,
-0.0014855593908578157,
0.009690511971712112,
-0.008642754517495632,
0.035843733698129654,
0.0009292077738791704,
0.013647902756929398,
0.008773496374487877,
-0.05373910814523697,
-0.0021887393668293953,
0.009645435959100723,
0.015436278656125069,
-0.0050554536283016205,
0.007038181181997061,
-0.007101749069988728,
0.0042930785566568375,
-0.019554341211915016,
-0.006201455369591713,
-0.011870518326759338,
-0.005727242678403854,
0.014393304474651814,
-0.012718325480818748,
0.010924838483333588,
-0.012121014297008514,
0.004465716890990734,
-0.0010268643964082003,
0.024234330281615257,
-0.005162414629012346,
-0.010768324136734009,
0.01537223532795906,
0.009475402534008026,
-0.01011448074132204,
0.003407570533454418,
0.027615414932370186,
0.038801409304142,
-0.010378668084740639,
0.011296479031443596,
0.017805330455303192,
-0.06692291796207428,
0.006017150357365608,
0.02199375256896019,
0.00611543282866478,
-0.004961270838975906,
-0.002307991264387965,
0.0063192350789904594,
-0.0021690113935619593,
-0.024412043392658234,
0.018339456990361214,
-0.012580564245581627,
0.0010920499917119741,
0.017867952585220337,
0.0004849343094974756,
0.019258826971054077,
0.009336601942777634,
-0.00434955395758152,
-0.03793574124574661,
0.02041494846343994,
-0.0020593965891748667,
0.011202562600374222,
-0.008660354651510715,
-0.0031077545136213303,
0.007844565436244011,
-0.010424860753118992,
0.004481053911149502,
0.009997688233852386,
-0.012940442189574242,
0.03230708837509155,
0.004312667530030012,
-0.02387111261487007,
-0.012500129640102386,
0.013171904720366001,
-0.025209292769432068,
0.004887845367193222,
-0.00694699352607131,
0.01571502722799778,
0.018165137618780136,
0.016964180395007133,
0.006257098168134689,
0.007789363153278828,
0.009503955021500587,
0.010758454911410809,
-0.00802581012248993,
0.002082396764308214,
-0.010264813899993896,
-0.0027047316543757915,
-0.015215693041682243,
-0.009139303117990494,
0.025036845356225967,
-0.0008484614081680775,
0.022370098158717155,
0.004674126394093037,
0.015245972201228142,
-0.002190332394093275,
0.014650270342826843,
0.022083310410380363,
0.0015245514223352075,
0.0066049229353666306,
0.0016311128856614232,
-0.007567396387457848,
-0.010792991146445274,
0.001884356141090393,
-0.016174552962183952,
-0.010075726546347141,
-0.008462650701403618,
-0.012425504624843597,
0.001487992936745286,
-0.02347501926124096,
0.0021607414819300175,
-0.0006535133579745889,
-0.014195945113897324,
0.008058048784732819,
0.001600598101504147,
-0.02466883882880211,
-0.0009263564134016633,
0.006583223585039377,
0.0036525349132716656,
0.016233034431934357,
0.013050821609795094,
-0.005844337400048971,
-0.006850871257483959,
-0.00348940072581172,
-0.00756051205098629,
-0.0023764835204929113,
0.0024490756914019585,
0.004812168423086405,
0.0037804136518388987,
-0.014498014003038406,
0.0156511589884758,
0.019785288721323013,
-0.015164101496338844,
-0.022886496037244797,
-0.007650977000594139,
0.01796790212392807,
-0.023910056799650192,
0.013625869527459145,
0.022387824952602386,
0.007124771364033222,
0.017125088721513748,
0.01133706234395504,
0.010100206360220909,
0.0025622572284191847,
-0.021150093525648117,
0.0034322324208915234,
-0.0015784617280587554,
-0.006616374012082815,
-0.004740208387374878,
0.005104805342853069,
0.006958958227187395,
-0.003835926065221429,
0.023013371974229813,
0.0067291418090462685,
-0.02073507010936737,
0.06675006449222565,
-0.0021559689193964005,
0.03687934949994087,
0.0063512613996863365,
-0.001684029819443822,
-0.0015140143223106861,
0.007272009737789631,
-0.003038430353626609,
-0.003490129718557,
0.01281895861029625,
-0.023869872093200684,
-0.00031585991382598877,
-0.0217441376298666,
-0.0025229817256331444,
0.0033077169209718704,
0.010645953007042408,
0.00429996894672513,
-0.014866321347653866,
0.005638543516397476,
-0.015405162237584591,
-0.012414560653269291,
0.011601930484175682,
-0.021245744079351425,
0.05031305551528931,
0.010863170959055424,
-0.01399075798690319,
0.008276527747511864,
-0.0034294212237000465,
-0.021467672660946846,
0.006223476491868496,
0.03643760830163956,
0.003881648648530245,
0.004024967085570097,
0.002785156015306711,
-0.004614090546965599,
0.010443153791129589,
-0.008432632312178612,
0.0007032239809632301,
0.012015663087368011,
0.020489774644374847,
-0.014663754031062126,
-0.008198484778404236,
0.0010997273493558168,
0.0017200163565576077,
0.0008598740678280592,
0.0263429656624794,
0.007097391411662102,
0.0028676572255790234,
0.00930473580956459,
0.018526459112763405,
0.00954500399529934,
-0.0147416852414608,
-0.005668025929480791,
-0.009517226368188858,
0.002343731001019478,
0.007940265350043774,
-0.014269065111875534,
0.009944701567292213,
-0.018795134499669075,
0.01653537154197693,
-0.016201894730329514,
-0.0034454839769750834,
-0.009607336483895779,
-0.028303474187850952,
0.0014383913949131966,
-0.01396489329636097,
0.0053168172016739845,
0.029100708663463593,
-0.03729145973920822,
0.007585933897644281,
0.009105079807341099,
0.006687099114060402,
0.013857480138540268,
0.02228315733373165,
0.019543476402759552,
0.031281478703022,
0.0022710165940225124,
-0.010672755539417267,
0.013276987709105015,
0.0235372893512249,
-0.008457046002149582,
0.000031997798942029476,
0.007031485438346863,
0.0017752517014741898,
0.010043089278042316,
0.007529879454523325,
-0.0051208725199103355,
-0.008244095370173454,
-0.002772310748696327,
0.019208205863833427,
0.00008890312165021896,
0.004985092207789421,
-0.0029001624789088964,
-0.00024348183069378138,
-0.08183976262807846,
-0.00835365615785122,
-0.00925980880856514,
0.015128420665860176,
0.007452939171344042,
-0.009227337315678596,
-0.0002922816202044487,
0.01825849525630474,
-0.013910133391618729,
0.025696996599435806,
-0.0048721060156822205,
-0.015997454524040222,
-0.015193508937954903,
-0.006512723863124847,
-0.014761237427592278,
-0.008823777548968792,
0.009370976127684116,
0.012531174346804619,
-0.00654757022857666,
-0.0015605734661221504,
0.00048730894923210144,
-0.033836375921964645,
-0.0013397340662777424,
0.01116511132568121,
-0.02608976885676384,
0.018636025488376617,
-0.005957703106105328,
-0.0034469515085220337,
-0.024665111675858498,
0.01233509462326765,
-0.0041568465530872345,
-0.005976628977805376,
-0.0001347772777080536,
-0.020882636308670044,
0.009486704133450985,
0.021007727831602097,
0.003093745093792677,
0.033271294087171555,
0.0015665970277041197,
0.017385367304086685,
0.007976951077580452,
0.023965923115611076,
-0.005563594866544008,
0.0051306975074112415,
-0.009737895801663399,
-0.0028612876776605844,
0.020361104980111122,
0.002311456948518753,
0.02242751233279705,
-0.00003594596637412906,
-0.014237888157367706,
-0.01766248233616352,
-0.007067583501338959,
0.01776989921927452,
-0.025262944400310516,
-0.020299091935157776,
-0.05705537647008896,
0.010477917268872261,
-0.008928495459258556,
-0.011636155657470226,
-0.014592941850423813,
-0.006924011278897524,
0.013821762055158615,
0.040551040321588516,
0.013405556790530682,
-0.0016330946236848831,
0.0022726841270923615,
0.009456956759095192,
-0.00870007835328579,
0.026850301772356033,
0.003385944990441203,
0.011419284157454967,
0.005766413174569607,
-0.0010207247687503695,
-0.0390227735042572,
-0.014176657423377037,
-0.011702836491167545,
0.017360374331474304,
0.004565533250570297,
-0.027657795697450638,
-0.02309424802660942,
0.006315323058515787,
-0.014456544071435928,
0.014895271509885788,
0.0023076189681887627,
-0.015226070769131184,
0.012647423893213272,
0.0043199993669986725,
0.0038117272779345512,
-0.022913096472620964,
0.024510351940989494,
0.019087281078100204,
0.02629910595715046,
0.007068365812301636,
-0.006469854153692722,
-0.02065783552825451,
0.01324419490993023,
0.009038879536092281,
0.03659772127866745,
0.007348504848778248,
-0.011832429096102715,
-0.013093916699290276,
0.0023999453987926245,
-0.017466694116592407,
0.00912979245185852,
0.008240018039941788,
0.013017496094107628,
0.0019876956939697266,
0.02130354940891266,
-0.0026867291890084743,
-0.008767000399529934,
-0.016200155019760132,
-0.007427884265780449,
0.006364232860505581,
0.01289457082748413,
0.012903367169201374,
0.01530243270099163,
-0.01927655190229416,
0.07264262437820435,
-0.019405324012041092,
-0.0056103491224348545,
-0.013899828307330608,
0.018434282392263412,
-0.01873764768242836,
-0.0414910688996315,
-0.004207794088870287,
0.021159056574106216,
-0.017220299690961838,
0.011042682453989983,
-0.0188760869204998,
-0.005954630672931671,
-0.01546978484839201,
-0.03460652381181717,
0.006803200580179691,
-0.021487712860107422,
-0.019152216613292694,
-0.019926752895116806,
-0.010023495182394981,
0.011917749419808388,
0.009994011372327805,
-0.0012207626132294536,
-0.00828325655311346,
0.003241761587560177,
-0.01255278941243887,
-0.013811422511935234,
-0.010793561115860939,
0.0005988248158246279,
0.008782900869846344,
0.00714537501335144,
0.021371856331825256,
-0.00886780396103859,
-0.011134352535009384,
0.0066226776689291,
-0.02127164602279663,
-0.0035683659370988607,
-0.0034249788150191307,
-0.009339035488665104,
0.0075795031152665615,
-0.010328629054129124,
-0.014093666337430477,
-0.003935887012630701,
0.006583098322153091,
0.05797797441482544,
-0.029174579307436943,
0.025270072743296623,
-0.007991474121809006,
-0.0004052723525092006,
0.019012387841939926,
-0.009031218476593494,
0.00976799987256527,
0.006867324002087116,
0.009437084197998047,
-0.021576043218374252,
0.013578404672443867,
-0.030306201428174973,
0.004371192771941423,
0.0027304249815642834,
0.017081880941987038,
-0.03505656495690346,
0.029235323891043663,
-0.01919490285217762,
0.0023240679875016212,
-0.017802178859710693,
0.007473404984921217,
0.025881804525852203,
0.02045355550944805,
0.008451603353023529,
-0.008245481178164482,
0.0016658976674079895,
-0.012159883975982666,
-0.00836734939366579,
-0.007890378125011921,
-0.015454747714102268,
-0.0320819653570652,
-0.00956733338534832,
0.013774879276752472,
0.0038269520737230778,
0.0022013909183442593,
-0.015041831880807877,
0.025989331305027008,
-0.018651334568858147,
-0.00627058045938611,
0.01414552889764309,
0.020901210606098175,
-0.008575220592319965,
-0.07519467920064926,
-0.02460164576768875,
0.0007435223087668419,
-0.004765958525240421,
-0.009382800199091434,
-0.03314100578427315,
-0.011238185688853264,
0.02582445926964283,
-0.031115012243390083,
-0.0004612942284438759,
0.0016142564127221704,
0.03706815093755722,
-0.0076329512521624565,
0.003441935870796442,
0.012033442035317421,
-0.00022640498355031013,
0.022951655089855194,
-0.003083864226937294,
-0.006511528976261616,
-0.012096581980586052,
0.005429512821137905,
0.008236024528741837,
0.009246944449841976,
0.0011370503343641758,
-0.004582607187330723,
-0.08139471709728241,
0.011257613077759743,
0.006621037144213915,
-0.03100615181028843,
0.01528474222868681,
0.01145132165402174,
0.0011930775362998247,
-0.014266462065279484,
0.01070726104080677,
-0.012375419959425926,
-0.022610515356063843,
0.0044920663349330425,
-0.0003562172641977668,
-0.012615710496902466,
-0.001363829942420125,
-0.004293177276849747,
0.03328336775302887,
-0.010141123086214066,
0.012526503764092922,
0.0034734185319393873,
0.00013698264956474304,
0.013465207070112228,
-0.004234470427036285,
0.016593225300312042,
-0.012740407139062881,
0.00004433724097907543,
0.012282575480639935,
0.016552234068512917,
-0.0010572411119937897,
0.008396817371249199,
0.011269628070294857,
-0.0036285943351686,
-0.006752295419573784,
-0.0006140284240245819,
-0.0024456693790853024,
-0.009198291227221489,
-0.013548667542636395,
-0.006326874252408743,
-0.02398896962404251,
-0.005582486279308796,
-0.006497002672404051,
-0.0069494303315877914,
0.024374814704060555,
-0.017781240865588188,
-0.009569616056978703,
0.013510866090655327,
0.008607335388660431,
-0.006177118048071861,
0.004705461673438549,
-0.01029539480805397,
-0.0006032985402271152,
-0.00028689438477158546,
0.014696286991238594,
0.02759445458650589,
-0.008345450274646282,
-0.0016364753246307373,
-0.003712562145665288,
-0.008815883658826351,
0.024181347340345383,
0.004415965173393488,
-0.0019272975623607635,
0.03500647097826004,
0.00794270820915699,
0.07192998379468918,
-0.0016554348403587937,
0.025888539850711823,
0.01898413710296154,
-0.004755331669002771,
0.004094772040843964,
-0.001201439881697297,
-0.01587636210024357,
-0.027116863057017326,
0.01137855090200901,
0.036426134407520294,
0.0020555034279823303,
-0.0017999995034188032,
0.015153387561440468,
0.019207650795578957,
-0.01989019475877285,
0.005768713541328907,
0.016810160130262375,
-0.0019198309164494276,
0.01445095706731081,
0.012817944400012493,
-0.005380491726100445,
0.011393563821911812,
0.01326736994087696,
-0.006097965408116579,
0.016455959528684616,
-0.006092811468988657,
-0.0028943042270839214,
-0.00686521315947175,
-0.025239482522010803,
-0.0062147267162799835,
-0.004393996205180883,
0.007919026538729668,
0.00285895261913538,
0.016025863587856293,
0.001625353586860001,
0.012373855337500572,
0.008831934072077274,
-0.0008731090347282588,
-0.0022665653377771378,
0.008355596102774143,
0.004860941786319017,
0.008103488944470882,
0.009360823780298233,
0.023226529359817505,
0.008630616590380669,
0.007646454498171806,
-0.03240638226270676,
0.016675442457199097,
-0.0024375859647989273,
-0.00957081001251936,
0.004829108715057373,
-0.022023364901542664,
-0.02032550796866417,
0.024170909076929092,
0.038217104971408844,
0.010552659630775452,
0.0025131525471806526,
0.03454706445336342,
-0.017505045980215073,
-0.004827194847166538,
-0.007728606928139925,
0.012576498091220856,
-0.001372368773445487,
0.018574098125100136,
-0.013768579810857773,
0.007720189169049263,
-0.016257163137197495,
-0.01682605966925621,
0.009137180633842945,
-0.02151624858379364,
-0.010261068120598793,
0.004636608064174652,
-0.006147840991616249,
0.012826602905988693,
0.013622814789414406,
-0.00004010472912341356,
-0.019961964339017868,
0.013829091563820839,
0.010259094648063183,
-0.01588786207139492,
0.052812911570072174,
-0.014815352857112885,
0.019920386373996735,
-0.021810386329889297,
-0.011507022194564342,
-0.0013254197547212243,
0.00021473783999681473,
-0.003938827197998762,
0.015302235260605812,
0.01872325874865055,
-0.007256597746163607,
0.01231722254306078,
0.013872519135475159,
0.009452663362026215,
0.03362748771905899,
0.039014119654893875,
0.004918835125863552,
0.028511328622698784,
0.006148976273834705,
0.012241425924003124,
0.014065450057387352,
-0.008275147527456284,
-0.016621269285678864,
0.005218395031988621,
-0.01118207722902298,
-0.022645892575383186,
0.011629542335867882,
-0.009232847020030022,
0.0030873522628098726,
-0.008029289543628693,
-0.003684550290927291,
0.029988398775458336,
0.019557306542992592,
0.01360047236084938,
0.011124880984425545,
-0.0010002056369557977,
0.004168626852333546,
-0.009368534199893475,
-0.010486241430044174,
0.005923167802393436,
-0.0051537444815039635,
0.004374977201223373,
0.03320413827896118,
-0.005656654480844736,
-0.00993279181420803,
-0.004840421490371227,
0.014038181863725185,
0.023114535957574844,
-0.019783180207014084,
0.006921466439962387,
0.002614016178995371,
-0.00657108286395669,
0.006157405208796263,
-0.01885807141661644,
-0.01549858320504427,
-0.0091949962079525,
0.018949009478092194,
-0.0059210979379713535,
0.0038067325949668884,
0.013073788955807686,
-0.0025307247415184975,
-0.0006585317896679044,
-0.02043205127120018,
0.0074081625789403915,
-0.02018596976995468,
-0.029241589829325676,
-0.007374321110546589,
0.006882526446133852,
0.04720716178417206,
-0.0012194415321573615,
0.0029851424042135477,
0.005497945472598076,
-0.003109409473836422,
0.021291278302669525,
0.023588653653860092,
0.0015625935047864914,
0.018084688112139702,
-0.019461633637547493,
-0.01410692185163498,
-0.017783600836992264,
-0.00774824945256114,
-0.00032992917113006115,
0.0016148859867826104,
0.004186942242085934,
0.003846072591841221,
-0.03488674759864807,
0.002737802919000387,
-0.0136734489351511,
-0.016832031309604645,
0.004691780544817448,
-0.006897396873682737,
-0.014520438387989998,
0.004561459645628929,
-0.0031415747944265604,
-0.009198026731610298,
0.013863570988178253,
0.017753344029188156,
0.003330381354317069,
0.010237708687782288,
0.010745305567979813,
0.026565469801425934,
-0.008196268230676651,
-0.010497262701392174,
0.003897068090736866,
0.0048156301490962505,
-0.012548894621431828,
-0.011275481432676315,
0.0044344100169837475,
0.022199999541044235,
0.007862474769353867,
-0.024628059938549995,
-0.01626952365040779,
0.009938002564013004,
-0.011732803657650948,
-0.012653632089495659,
0.004576277919113636,
-0.02350619062781334,
0.003709948854520917,
-0.01062801107764244,
-0.013730697333812714,
-0.00923016108572483
] | [
-0.06568481773138046,
-0.22270411252975464,
0.37886565923690796,
0.07135458290576935,
0.45060932636260986,
0.16192978620529175,
0.006643296685069799,
0.02419637143611908,
-0.04346725344657898,
-0.403653621673584,
-0.21810775995254517,
0.5276691317558289,
0.28866517543792725,
-0.40890932083129883,
0.31197285652160645,
-0.06735838204622269,
0.7511114478111267,
0.13555970788002014,
-0.34850504994392395,
-0.5418474674224854,
-0.40201547741889954,
-0.17043140530586243,
0.20074164867401123,
0.17883707582950592,
-0.018152548000216484,
0.30635470151901245,
0.12870632112026215,
-0.23660965263843536,
0.3368379473686218,
-0.2728131413459778,
0.35843631625175476,
0.36871498823165894,
-0.17666120827198029,
-0.6800763607025146,
0.0158653873950243,
-0.02266264148056507,
-0.3069744408130646,
-0.13854020833969116,
-0.27735385298728943,
-0.5987462401390076,
-0.07737082988023758,
0.011923465877771378,
-0.08066841959953308,
0.2665479779243469,
-0.0020211953669786453,
-0.18024775385856628,
-1.422662615776062,
-0.13459526002407074,
-0.804357647895813,
0.38712000846862793,
0.004171876702457666,
0.1763230562210083,
0.16350741684436798,
-0.09003084152936935,
-0.1944269835948944,
0.14103373885154724,
-0.5217164158821106,
-0.30852124094963074,
0.3404671251773834,
-0.24665716290473938,
0.022600896656513214,
0.1596863567829132,
-0.11605417728424072,
0.3044780194759369,
-0.10270997136831284,
0.04866223782300949,
0.23650668561458588,
0.17451412975788116,
0.13758867979049683,
-0.2596328854560852,
0.44045373797416687,
-0.15290303528308868,
-0.2490234225988388,
0.030162623152136803,
0.0885055661201477,
-0.563579261302948,
0.39057692885398865,
-0.4300544857978821,
0.2379739135503769,
-0.020040644332766533,
0.34015071392059326,
0.5568048357963562,
0.2435246706008911,
-0.30464914441108704,
0.7244727611541748,
0.16850414872169495,
-0.5056529641151428,
0.3956131339073181,
-0.24513016641139984,
0.17279960215091705,
-0.11472409963607788,
-0.5567384362220764,
0.4883463680744171,
0.2097300887107849,
0.6229296326637268,
0.4126611351966858,
-0.07579158246517181,
-0.21554964780807495,
0.19615676999092102,
-0.09453008323907852,
-0.37153005599975586,
0.27068236470222473,
-0.44598841667175293,
-0.19673526287078857,
0.19842472672462463,
0.03583730384707451,
-0.24864812195301056,
-0.39170175790786743,
-0.586890697479248,
0.04271113499999046,
-0.39194560050964355,
-0.1467636227607727,
-0.06426960974931717,
-0.10234817862510681,
-0.04251531511545181,
-0.09763364493846893,
0.6098412871360779,
-0.0440046451985836,
-0.6000797748565674,
0.38796183466911316,
0.05549461394548416,
0.8660283088684082,
-0.08581934124231339,
0.24172259867191315,
0.1931508630514145,
0.011548361741006374,
0.2302180677652359,
0.32650741934776306,
-0.5457044243812561,
0.37684670090675354,
-0.17444652318954468,
0.6653907895088196,
0.03282446786761284,
-0.14331774413585663,
0.10926360636949539,
-0.07069206982851028,
0.05186576396226883,
0.16919133067131042,
0.08956444263458252,
0.5374977588653564,
-0.13772927224636078,
-0.20230115950107574,
-0.25997525453567505,
-0.055530305951833725,
-0.08295071125030518,
-0.2551868259906769,
0.003863320918753743,
0.07528528571128845,
0.028501590713858604,
-0.02800561487674713,
-0.22778017818927765,
-0.07371395826339722,
-0.7288183569908142,
-0.1755143105983734,
0.020549476146697998,
1.0992738008499146,
-0.021913116797804832,
0.052863337099552155,
-0.027182944118976593,
-0.09848807007074356,
0.5710698962211609,
0.158567875623703,
-0.5566160678863525,
-0.07128322869539261,
0.342195987701416,
-0.21590380370616913,
-0.16019512712955475,
0.20964616537094116,
0.48770469427108765,
0.008322592824697495,
0.013864208944141865,
-0.07180643081665039,
-0.4318292737007141,
-0.46365588903427124,
0.05338134989142418,
0.15551525354385376,
0.5832439661026001,
0.5474368929862976,
0.0643855482339859,
0.3386838138103485,
-0.650542676448822,
0.1656249612569809,
-0.2007838934659958,
-1.210398554801941,
0.2008875608444214,
0.1584061086177826,
0.5493378043174744,
0.2140577733516693,
-0.07491043955087662,
0.2287745624780655,
0.08745983242988586,
-0.2549227178096771,
0.39701154828071594,
-0.5817496180534363,
1.2681150436401367,
-0.22789058089256287,
-0.04412841796875,
1.1535377502441406,
-0.19137290120124817,
0.03892349451780319,
0.19667652249336243,
0.5045506358146667,
0.6860875487327576,
-0.05722765251994133,
-0.46603870391845703,
0.1866309493780136,
0.3297485113143921,
-0.5755091309547424,
-0.22493329644203186,
-0.09482525289058685,
0.5707046389579773,
0.11674252152442932,
0.2213078886270523,
-0.3659273386001587,
0.3609849512577057,
-0.3248704969882965,
-0.08676488697528839,
0.37053605914115906,
0.013153606094419956,
0.1101086437702179,
1.0018792152404785,
-0.6574830412864685,
0.3494728207588196,
0.6984358429908752,
-0.34935078024864197,
0.5066379308700562,
0.4560583531856537,
0.0353936068713665,
0.8831230998039246,
-0.5353862643241882,
-0.0020497480873018503,
-0.5911712646484375,
0.055761415511369705,
-0.17919188737869263,
-0.0909615308046341,
0.11305689066648483,
-0.25334975123405457,
-0.4490402340888977,
0.05928998813033104,
0.31959861516952515,
0.0886508896946907,
0.21221208572387695,
-0.7207967638969421,
0.45256438851356506,
0.4878668189048767,
-0.24945345520973206,
-0.39685800671577454,
0.07419466227293015,
-0.3562964200973511,
0.166965514421463,
-0.17957447469234467,
0.30657461285591125,
0.007291688583791256,
-0.34708860516548157,
0.5051277875900269,
-0.027122925966978073,
0.04986979439854622,
0.09774841368198395,
0.39420124888420105,
0.15780143439769745,
-0.07054433226585388,
-0.010429583489894867,
0.3548058271408081,
0.3091888427734375,
0.030832327902317047,
-0.6323035955429077,
-0.7111803293228149,
-0.5545735359191895,
0.5456228852272034,
0.32291847467422485,
0.7136103510856628,
0.1037619486451149,
-0.26912638545036316,
0.021956654265522957,
-0.3738504946231842,
-0.8016472458839417,
0.191436767578125,
0.7373132705688477,
-0.46179741621017456,
-0.7213742136955261,
0.028445648029446602,
0.37963369488716125,
0.4292559027671814,
-0.12416968494653702,
-0.013883398845791817,
-0.05886051058769226,
-0.0943569540977478,
-0.38835179805755615,
-0.5409184694290161,
-0.3115297555923462,
0.2702217102050781,
0.19150207936763763,
0.05541551113128662,
-0.2587588131427765,
0.462205171585083,
0.6311321258544922,
0.02849465049803257,
0.621736466884613,
-0.0270950049161911,
0.12778252363204956,
-0.24625901877880096,
0.3093622326850891,
0.001162778353318572,
0.2853391468524933,
0.03126806765794754,
-0.2559424042701721,
-0.21466462314128876,
-0.132613867521286,
-6.138882160186768,
0.019404731690883636,
-0.5281489491462708,
0.2582033574581146,
-0.1192869022488594,
0.19153964519500732,
0.8681877255439758,
-0.0694132000207901,
0.24356043338775635,
-0.020623283460736275,
-0.22861690819263458,
0.5909410715103149,
0.053462203592061996,
0.2959766387939453,
-0.05240285024046898,
0.2656014561653137,
-0.3985999822616577,
0.19697557389736176,
0.1727832704782486,
0.17098309099674225,
-0.14347133040428162,
-0.7009909749031067,
0.22603362798690796,
0.44348055124282837,
0.194601908326149,
-0.1997734159231186,
-1.098973274230957,
0.8723964691162109,
-0.07152040302753448,
0.00939022097736597,
0.2832239866256714,
-0.7497329115867615,
-0.09904217720031738,
-0.527071475982666,
0.07368314266204834,
0.00014768514665775,
0.646296501159668,
0.19454093277454376,
0.3767809569835663,
-0.6560378670692444,
0.0291508249938488,
0.01621873304247856,
-0.12950877845287323,
-0.2618183195590973,
-0.12936250865459442,
-0.3108725845813751,
0.45192545652389526,
0.4263826608657837,
-0.36971497535705566,
1.241415023803711,
-0.23451821506023407,
0.07720578461885452,
0.22524404525756836,
0.22609348595142365,
0.22086185216903687,
-0.5074353814125061,
-0.026250595226883888,
0.4455850124359131,
0.16419275104999542,
0.4262435734272003,
0.06932852417230606,
-0.06454590708017349,
0.014541768468916416,
-0.9631210565567017,
0.02384174056351185,
0.44689449667930603,
-0.9317010641098022,
-0.3857104182243347,
0.1542252153158188,
0.29892778396606445,
-0.17835745215415955,
0.5214463472366333,
-0.08128223568201065,
-0.7302387356758118,
0.011507214978337288,
-0.6228552460670471,
0.5128191709518433,
-0.3227853775024414,
-0.012057146057486534,
0.2005913406610489,
-0.0021355885546654463,
-0.061642393469810486,
0.11685382574796677,
0.26144835352897644,
0.3090493381023407,
0.29069942235946655,
0.002533413702622056,
-0.42150548100471497,
-0.3806445002555847,
0.15909665822982788,
0.4304986000061035,
0.11444827914237976,
-0.2823776304721832,
0.6506445407867432,
0.08507275581359863,
0.28938376903533936,
-0.048558350652456284,
0.14802312850952148,
0.16896730661392212,
-0.4728127717971802,
0.7875276207923889,
0.13972781598567963,
-0.1526753306388855,
-0.5752363204956055,
-0.012503624893724918,
-0.21594274044036865,
-0.6678601503372192,
-0.14836280047893524,
0.48664459586143494,
-0.38290661573410034,
-0.37781962752342224,
-0.17239148914813995,
-0.09775031358003616,
-0.3780665993690491,
0.22457356750965118,
0.42093148827552795,
-0.2007683962583542,
-0.32515379786491394,
0.3551662564277649,
-0.24146942794322968,
0.4215473532676697,
0.16915416717529297,
0.38371366262435913,
0.18340134620666504,
0.17401087284088135,
-0.1565348207950592,
0.21808850765228271,
0.5695186257362366,
-0.3543418347835541,
0.0002746048558037728,
0.13429243862628937,
0.4410945177078247,
-0.3193521499633789,
0.11222318559885025,
0.24051588773727417,
-0.39867737889289856,
-0.8637235164642334,
0.07820505648851395,
0.3059368431568146,
0.15265905857086182,
0.21701887249946594,
-0.3570448160171509,
-0.2137422114610672,
-0.08334390074014664,
0.25446680188179016,
-0.02033095248043537,
-0.27040427923202515,
-0.1091364175081253,
-0.46048611402511597,
0.1671280413866043,
0.3353799283504486,
-0.4200492799282074,
0.10399045050144196,
-0.020366784185171127,
-0.30716416239738464,
-0.09727585315704346,
0.4952629506587982,
-0.1527058333158493,
0.16546964645385742,
-0.22869977355003357,
0.3519846498966217,
0.12205111235380173,
-0.9336481690406799,
-0.2262715846300125,
0.3795197308063507,
-0.11058294773101807,
-0.4323974847793579,
-0.7077319622039795,
-0.19958743453025818,
-0.03313938528299332,
-0.1132141649723053,
-0.5210093855857849,
-0.3235783576965332,
-0.3962986469268799,
0.30694472789764404,
0.23674294352531433,
-0.16051164269447327,
0.04923493042588234,
-0.029585041105747223,
-0.18357646465301514,
0.3973003327846527,
-0.7514981627464294,
-0.29772257804870605,
0.0700087770819664,
0.9125869870185852,
-0.03651691600680351,
0.15878504514694214,
-0.28053972125053406,
-0.40730002522468567,
-0.0999903753399849,
0.32919076085090637,
0.5119235515594482,
0.4664000868797302,
0.2851239740848541,
-0.054720427840948105,
-0.3092510402202606,
-0.3514738082885742,
0.29178106784820557,
-0.09939146786928177,
-0.27440837025642395,
-0.056864283978939056,
0.06509015709161758,
-0.027308231219649315,
0.47580814361572266,
-0.09235013276338577,
-0.26904839277267456,
-0.05870651453733444,
0.19309456646442413,
-0.06965470314025879,
0.04264720529317856,
-0.09053588658571243,
-0.4121779501438141,
0.21926644444465637,
0.272565633058548,
-0.6933720707893372,
0.2656804919242859,
0.06600949168205261,
-0.6960132122039795,
-0.7880544066429138,
0.22735370695590973,
-0.09439776837825775,
0.09741690009832382,
-0.26646319031715393,
-0.22077350318431854,
-0.44250068068504333,
0.015381218865513802,
0.5626975297927856,
-0.5020809173583984,
-0.17026259005069733,
0.366367369890213,
-0.7902836799621582,
-0.004255495499819517,
-0.01892564818263054,
-0.29703062772750854,
-0.3479471206665039,
0.09062167257070541,
-0.20868852734565735,
0.09557195752859116,
-0.30778902769088745,
0.18517489731311798,
-0.33568671345710754,
0.2577804923057556,
-0.16356420516967773,
-0.508286714553833,
-0.1272936463356018,
0.4853573143482208,
0.4175279140472412,
-0.48563241958618164,
-0.24887733161449432,
0.08958705514669418,
0.3336915373802185,
-0.37409332394599915,
0.18452170491218567,
-0.4788687229156494,
0.5155551433563232,
-0.007520128972828388,
-0.35707956552505493,
-0.3291959762573242,
-0.07566993683576584,
-0.22526581585407257,
0.16097885370254517,
-0.32021498680114746,
-0.5230769515037537,
-0.029264898970723152,
0.19849956035614014,
0.07909766584634781,
-0.14847171306610107,
-0.6906165480613708,
0.12706904113292694,
-0.3338058590888977,
0.48644787073135376,
-0.21513256430625916,
0.39300796389579773,
0.23642776906490326,
0.19010122120380402,
0.06780082732439041,
-0.14683140814304352,
-0.3284164369106293,
0.15464432537555695,
0.25658494234085083,
-0.39412644505500793,
-0.09549245238304138,
-0.022353313863277435,
0.19954675436019897,
0.20611457526683807,
-0.2328086942434311,
-0.17706692218780518,
0.12744387984275818,
0.010003294795751572,
0.5133458375930786,
-0.03330039232969284,
0.2566514313220978,
-0.7528399229049683,
-0.09250533580780029,
0.21569490432739258,
0.13806383311748505,
0.018886331468820572,
0.12389804422855377,
-0.11875541508197784,
-0.2522295415401459,
-0.24418193101882935,
0.48377981781959534,
0.4682735502719879,
-0.5210678577423096,
-0.15019948780536652,
0.5972212553024292,
0.08599041402339935,
0.003860712982714176,
-0.265336275100708,
0.10772048681974411,
0.31766965985298157,
-0.40178000926971436,
-0.12169502675533295,
0.8294076323509216,
-0.585220456123352,
-0.21299223601818085,
-0.14184728264808655,
-0.5151082873344421,
0.36540487408638,
0.3489282429218292,
-0.008551533333957195,
0.9465917944908142,
0.3025774359703064,
-0.48723703622817993,
-0.500194787979126,
0.3892512917518616,
0.11332825571298599,
0.23534025251865387,
-0.27440980076789856,
0.4817313849925995,
0.940412700176239,
0.9372237324714661,
-0.13438446819782257,
0.314574271440506,
0.05560876056551933,
0.0739412009716034,
0.23865580558776855,
-0.5435195565223694,
-0.1788121908903122,
0.09831630438566208,
0.2918514311313629,
0.6946796774864197,
-0.27142134308815,
0.21594908833503723,
-0.2195606678724289,
0.6809505820274353,
0.22115576267242432,
0.28643715381622314,
-0.14899954199790955,
0.11172216385602951,
0.17843537032604218,
-0.033258404582738876,
0.16641555726528168,
-0.2924010753631592,
-0.4198334217071533,
0.19053484499454498,
0.23209917545318604,
0.021661996841430664,
0.14153319597244263,
0.05140811204910278,
0.13387472927570343,
0.5689717531204224,
0.15553666651248932,
0.08736985176801682,
-0.2988775968551636,
-0.11612286418676376,
0.5999791026115417,
0.005506759509444237,
0.052589889615774155,
-0.20075763761997223,
-0.28667670488357544,
0.3357943892478943,
-0.8040030598640442,
0.48478665947914124,
-0.14517410099506378,
-0.500003457069397,
0.16485151648521423,
0.3411492705345154,
-0.0852813869714737,
0.2990317940711975,
-0.03907467797398567,
-0.1066579520702362,
-0.32995572686195374,
-0.5740835666656494,
-0.006396224722266197,
0.017441337928175926,
0.14508689939975739,
0.20158931612968445,
0.2839182913303375,
0.33321863412857056,
-0.6431730389595032,
-0.8226468563079834,
0.012355487793684006,
0.03909093886613846,
0.32756540179252625,
0.01594538986682892,
-0.07584388554096222,
0.5499200224876404,
0.24035269021987915,
0.043072409927845,
-0.19155818223953247,
0.3966841697692871,
-0.13960838317871094,
-0.3220526874065399,
-0.14848880469799042,
0.650812029838562,
-0.49192166328430176,
0.1369772106409073,
-0.34986743330955505,
-0.15543794631958008,
0.6731436252593994,
0.6857317686080933,
-0.2625596225261688,
-0.04853396862745285,
0.29982253909111023,
0.2653113901615143,
0.33938002586364746,
-0.37573152780532837,
-0.09377779811620712,
-0.11945954710245132,
-0.799307644367218,
-0.20401982963085175,
0.02465718425810337,
-0.06971745193004608,
-0.3735051155090332,
-0.0026768743991851807,
0.1211709976196289,
0.2466115802526474,
-0.4008810222148895,
0.48304489254951477,
-0.06823966652154922,
-0.5051994919776917,
-0.8041794896125793,
0.4079044759273529,
-0.31430578231811523,
0.3359643220901489,
-0.421320378780365,
-0.22954759001731873,
0.26909810304641724,
-0.22809991240501404,
0.05235517770051956,
0.020745806396007538,
-0.18823379278182983,
0.41343921422958374,
-0.2251977026462555,
0.015812605619430542,
-0.2908293306827545,
-0.18690800666809082,
-0.5126959085464478,
-0.16965995728969574,
0.14339640736579895,
-0.5976816415786743,
-0.011862611398100853,
-0.08834396302700043,
-0.3938959538936615,
0.24347399175167084,
-0.17262840270996094,
-0.4304596483707428,
-0.19683663547039032,
-0.03661477938294411
] |
It is widely feared that a novel, highly pathogenic, human transmissible influenza virus may evolve that could cause the next global pandemic. Mitigating the spread of such an influenza pandemic would require not only the timely administration of antiviral drugs to those infected, but also the implementation of suitable intervention policies for stunting the spread of the virus. Towards this end, mathematical modelling and simulation studies are crucial as they allow us to evaluate the predicted effectiveness of the various intervention policies before enforcing them. Diagnosis plays a vital role in the overall pandemic management framework by detecting and distinguishing the pathogenic strain from the less threatening seasonal strains and other influenza-like illnesses. This allows treatment and intervention to be deployed effectively, given limited antiviral supplies and other resources. However, the time required to design a fast and accurate testkit for novel strains may limit the role of diagnosis. Herein, we aim to investigate the cost and effectiveness of different diagnostic methods using a stochastic agent-based city-scale model, and then address the issue of whether conventional testing approaches, when used with appropriate intervention policies, can be as effective as fast testkits in containing a pandemic outbreak. We found that for mitigation purposes, fast and accurate testkits are not necessary as long as sufficient medication is given, and are generally recommended only when used with extensive contact tracing and prophylaxis. Additionally, in the event of insufficient medication and fast testkits, the use of slower, conventional testkits together with proper isolation policies while waiting for the diagnostic results can be an equally effective substitute. | [
-0.007137722801417112,
0.020222902297973633,
-0.002828841097652912,
0.010095879435539246,
0.01912376657128334,
-0.009727440774440765,
0.008093912154436111,
0.023252524435520172,
-0.016128472983837128,
-0.03527665138244629,
-0.0043077836744487286,
0.01452062651515007,
-0.003973837476223707,
0.011872265487909317,
0.026595458388328552,
-0.011533549055457115,
0.0024848133325576782,
0.015694959089159966,
0.003335717599838972,
-0.02030859887599945,
-0.023726753890514374,
0.028331488370895386,
0.011243253946304321,
0.02443147823214531,
0.02616504766047001,
0.005109995603561401,
-0.008688084781169891,
-0.03092227689921856,
0.00924302265048027,
-0.02286216802895069,
-0.019182849675416946,
0.02569500356912613,
0.02848857268691063,
0.017812171950936317,
0.0034717125818133354,
0.0007329366635531187,
0.0002848449512384832,
0.029109647497534752,
-0.016810942441225052,
-0.0032526724971830845,
0.01310940645635128,
-0.009163729846477509,
0.00250080949626863,
-0.021567847579717636,
-0.00717814639210701,
0.04417651146650314,
0.004441521130502224,
0.009013811126351357,
-0.020697886124253273,
0.00978025235235691,
-0.0027734951581805944,
-0.004064931999891996,
-0.013398817740380764,
0.01100075151771307,
-0.0066031841561198235,
-0.008516363799571991,
0.021105198189616203,
-0.01208418421447277,
-0.04268771409988403,
0.03562306985259056,
-0.011044040322303772,
0.010528236627578735,
0.02219417691230774,
-0.028324685990810394,
-0.00423030648380518,
-0.06737153232097626,
-0.005745021626353264,
0.027500145137310028,
0.026905950158834457,
0.029835548251867294,
0.0031756008975207806,
0.009711319580674171,
-0.02381664142012596,
-0.010365583933889866,
-0.014096271246671677,
0.008955284021794796,
-0.0028677622321993113,
0.024480439722537994,
0.02938961051404476,
0.0026202136650681496,
-0.02553262561559677,
-0.005993477068841457,
0.022953618317842484,
0.02635287120938301,
-0.013582413084805012,
0.01246594823896885,
-0.013545440509915352,
-0.0020981498528271914,
-0.001528142485767603,
0.009298047050833702,
0.004280108027160168,
-0.025605352595448494,
-0.01886811852455139,
0.012147147208452225,
0.005825440399348736,
-0.02497485652565956,
-0.01551107782870531,
0.009911006316542625,
-0.0023965328000485897,
-0.009123953059315681,
0.003704652190208435,
-0.003313844557851553,
0.020319420844316483,
-0.004445966333150864,
-0.011793511919677258,
0.009823615662753582,
-0.023290347307920456,
0.0033724275417625904,
-0.005230929236859083,
0.00351076596416533,
0.009015638381242752,
-0.0030554940458387136,
0.005793293472379446,
0.018330473452806473,
0.019248129799962044,
0.0006408495828509331,
-0.0076096090488135815,
0.029689554125070572,
0.01647321507334709,
0.02716568484902382,
0.021240796893835068,
0.004513812251389027,
0.00645515788346529,
0.004698730073869228,
0.0036607980728149414,
0.0011704121716320515,
0.02233561873435974,
0.005952573847025633,
0.003986332565546036,
0.026757104322314262,
-0.007183966226875782,
0.00529400072991848,
0.011444923467934132,
0.011744337156414986,
0.010464614257216454,
0.007188950665295124,
-0.0009922313038259745,
-0.007875924929976463,
-0.004357622005045414,
-0.0165877565741539,
-0.015332628972828388,
0.006695929449051619,
-0.009035652503371239,
0.019831396639347076,
0.02610579878091812,
0.0016837961738929152,
-0.01826939731836319,
0.016699332743883133,
0.018040094524621964,
0.035635560750961304,
0.008186965249478817,
0.01738199219107628,
-0.0009243921376764774,
-0.017896760255098343,
-0.004986393265426159,
-0.004799371585249901,
0.002918480895459652,
-0.03350358456373215,
-0.02392258495092392,
0.013095850124955177,
-0.008084116503596306,
-0.009333984926342964,
-0.020388014614582062,
0.006801755167543888,
0.0075559355318546295,
0.004412270151078701,
-0.004110523499548435,
-0.0074388254433870316,
-0.009770479053258896,
0.0046300096437335014,
-0.019113019108772278,
-0.0020851134322583675,
-0.0060311732813715935,
0.010059362277388573,
-0.00629775645211339,
0.00581579003483057,
0.017405377700924873,
0.007824547588825226,
-0.009354574605822563,
0.0671028271317482,
-0.016742374747991562,
0.012166239321231842,
-0.0150412293151021,
0.0032497034408152103,
-0.011231239885091782,
-0.003096912521868944,
0.04200233146548271,
-0.010746721178293228,
-0.0039372434839606285,
0.0032422016374766827,
-0.02118486911058426,
-0.011609668843448162,
-0.01204021368175745,
-0.005652518942952156,
-0.01062244176864624,
0.003197630401700735,
0.012130232527852058,
-0.005529385060071945,
-0.01256081834435463,
-0.007959459908306599,
0.016401827335357666,
-0.0005725668743252754,
0.04572475701570511,
0.011022156104445457,
0.009242340922355652,
0.010527725331485271,
0.022694168612360954,
-0.0015907943015918136,
0.02843143418431282,
-0.0024472514633089304,
0.02010016143321991,
-0.022135987877845764,
0.006343454122543335,
-0.011291217058897018,
-0.01990397647023201,
-0.00011022319085896015,
-0.004629515111446381,
0.003323886077851057,
0.016091544181108475,
-0.012626126408576965,
-0.0003479036968201399,
0.0020733901765197515,
-0.04345124959945679,
0.0004656256642192602,
0.04404040426015854,
-0.0036074116360396147,
0.0035199690610170364,
0.012364947237074375,
0.014933787286281586,
-0.010565085336565971,
-0.009427785873413086,
-0.011020958423614502,
-0.008643059059977531,
-0.012393724173307419,
0.0009335605427622795,
-0.021617338061332703,
0.009259963408112526,
-0.027891959995031357,
0.01796596124768257,
-0.01478967722505331,
-0.0071959542110562325,
-0.0021270106080919504,
0.007167956791818142,
0.0029857915360480547,
-0.00009411387145519257,
0.0037501954939216375,
0.01070623192936182,
-0.01622515171766281,
0.003813102375715971,
-0.011263571679592133,
0.005565768573433161,
0.0032855160534381866,
0.009679392911493778,
-0.005570791661739349,
0.006108507048338652,
-0.005218925420194864,
0.012769881635904312,
0.010002832859754562,
0.022689998149871826,
-0.009879441931843758,
0.006994510535150766,
0.004637710750102997,
-0.017330676317214966,
-0.017637114971876144,
0.0037375669926404953,
0.044072166085243225,
0.03561366721987724,
0.012274790555238724,
0.013850884512066841,
0.022323353216052055,
0.00022724876180291176,
0.0013851848198100924,
-0.016687747091054916,
-0.08173063397407532,
-0.01674596220254898,
-0.01569456234574318,
0.00544333178550005,
0.013537095859646797,
-0.006762330885976553,
-0.009601298719644547,
0.0002265129005536437,
-0.018656590953469276,
0.04573320224881172,
0.0011951772030442953,
0.004769255872815847,
-0.008691253140568733,
0.00856107845902443,
-0.0008584208553656936,
-0.003748941468074918,
-0.0023259203881025314,
0.0328645259141922,
-0.01562199555337429,
0.009015153162181377,
-0.015504174865782261,
-0.02089809812605381,
0.025979982689023018,
-0.013945727609097958,
0.015132412314414978,
0.009954254142940044,
0.006647526752203703,
-0.004139869473874569,
-0.01137749943882227,
0.011253059841692448,
0.01018050778657198,
-0.04422614723443985,
0.0037891604006290436,
-0.022900931537151337,
0.017919981852173805,
0.013559186831116676,
0.0062677389942109585,
-0.0018844257574528456,
0.002881180727854371,
-0.021185236051678658,
0.014919472858309746,
0.007176519371569157,
0.008289063349366188,
0.003477358492091298,
0.015788067132234573,
0.0034426692873239517,
0.014975711703300476,
-0.0012709582224488258,
0.014872965402901173,
0.02444009855389595,
-0.012663803994655609,
-0.0018446579342707992,
0.015372935682535172,
0.014756930060684681,
-0.010158649645745754,
-0.013209768570959568,
-0.008572434075176716,
0.006512302439659834,
-0.020427359268069267,
-0.004884827416390181,
-0.015824759379029274,
0.008998226374387741,
0.014948740601539612,
0.002345101907849312,
-0.04375157505273819,
-0.012252537533640862,
0.01352662593126297,
0.015733741223812103,
-0.01089285034686327,
0.010662190616130829,
0.019666066393256187,
-0.00659533916041255,
0.01569238305091858,
0.0020868536084890366,
0.024629712104797363,
-0.0111235985532403,
-0.016193049028515816,
-0.018382690846920013,
-0.005812469869852066,
0.018647996708750725,
-0.01667533814907074,
0.019467424601316452,
0.0042145443148911,
0.005701929330825806,
-0.01139623112976551,
-0.003365540411323309,
0.009289387613534927,
-0.03159106522798538,
0.011884002014994621,
-0.01903442293405533,
0.020098350942134857,
0.01853584311902523,
-0.027018144726753235,
0.002387832850217819,
-0.02452906221151352,
-0.02758532389998436,
0.005646976176649332,
-0.008378973230719566,
0.012261049821972847,
0.011310005560517311,
-0.012018511071801186,
-0.0039099110290408134,
0.013341239653527737,
-0.010227221995592117,
-0.03602977097034454,
0.020661797374486923,
0.007015962153673172,
-0.02941136620938778,
-0.019715458154678345,
-0.017010051757097244,
-0.0049962387420237064,
0.02017907239496708,
-0.0010400216560810804,
0.033636674284935,
0.009731029160320759,
0.022348802536725998,
0.009964225813746452,
0.009050783701241016,
0.07230961322784424,
0.0005051319021731615,
0.005264032632112503,
-0.015734553337097168,
0.009442377835512161,
-0.017703570425510406,
0.0027060601860284805,
0.001848622690886259,
0.029111605137586594,
-0.024404242634773254,
0.010813616216182709,
-0.02065952494740486,
0.007020778954029083,
-0.013592958450317383,
-0.025650832802057266,
-0.00656021386384964,
0.0016010673716664314,
-0.024578966200351715,
0.003841755446046591,
-0.000730894214939326,
-0.005236506462097168,
-0.011310169473290443,
-0.009640753269195557,
0.008467750623822212,
0.011839245446026325,
-0.002590558957308531,
0.008215862326323986,
-0.012039353139698505,
-0.006772710010409355,
0.004648181609809399,
0.004092112649232149,
-0.003078005975112319,
0.0008144685998558998,
-0.012456723488867283,
-0.010618082247674465,
-0.005595165304839611,
-0.008524179458618164,
-0.007906490936875343,
-0.00972314365208149,
-0.00360945425927639,
0.003157134633511305,
-0.0161112193018198,
-0.01388753205537796,
0.03192397579550743,
-0.02243221178650856,
0.012523138895630836,
-0.025309590622782707,
-0.003155331825837493,
-0.014378521591424942,
0.022961150854825974,
-0.009850112721323967,
0.0009283347753807902,
0.006867253687232733,
0.026773788034915924,
-0.010425148531794548,
0.006277512293308973,
0.006124414969235659,
-0.008084655739367008,
0.005270069465041161,
0.019817914813756943,
-0.00005556084215641022,
-0.014814881607890129,
0.02516857162117958,
-0.030192047357559204,
0.0007905536331236362,
-0.024837931618094444,
-0.0032837549224495888,
0.008922982029616833,
-0.014931180514395237,
-0.000884960638359189,
0.012539725750684738,
-0.007711244281381369,
0.006079487502574921,
-0.0016732646618038416,
-0.05031219497323036,
-0.008575942367315292,
-0.04398704320192337,
-0.0016295132227241993,
-0.024942602962255478,
-0.0012766839936375618,
0.008528987877070904,
-0.014725212007761002,
0.021046888083219528,
0.00443156948313117,
-0.010381575673818588,
0.006220492534339428,
-0.010633263736963272,
-0.07421576976776123,
-0.008702350780367851,
0.0016378178261220455,
-0.010144174098968506,
-0.008382242172956467,
0.003352642059326172,
-0.003358252113685012,
0.005477270111441612,
0.0010308576747775078,
-0.006130896974354982,
-0.007338670082390308,
0.0014118407852947712,
0.022303245961666107,
0.009814666584134102,
0.01272428035736084,
0.020086631178855896,
-0.029037978500127792,
0.01612534187734127,
-0.008481952361762524,
-0.0016439645551145077,
0.006512009538710117,
0.0007932556327432394,
-0.006324502639472485,
-0.010022031143307686,
0.01272173784673214,
-0.08098062872886658,
-0.02920028753578663,
0.02373427338898182,
-0.02242421917617321,
0.00574036268517375,
-0.016242951154708862,
0.025733159855008125,
-0.02083556540310383,
-0.027886686846613884,
-0.01838235929608345,
-0.014191254042088985,
0.015145022422075272,
-0.021184150129556656,
0.0118867177516222,
0.027607763186097145,
-0.006408521439880133,
0.009393850341439247,
0.020999528467655182,
0.028111346065998077,
-0.019810084253549576,
0.02921328693628311,
0.00473933108150959,
-0.009132481180131435,
-0.0021613305434584618,
-0.016097091138362885,
-0.009032152593135834,
0.009480305947363377,
0.006161924917250872,
-0.002790275029838085,
-0.004165692254900932,
-0.012035906314849854,
-0.003688471857458353,
0.01686697080731392,
-0.010013928636908531,
0.00981686357408762,
-0.00027286040131002665,
0.010078661143779755,
0.004935529548674822,
0.02036239579319954,
-0.002121325582265854,
-0.009816449135541916,
0.023115085437893867,
-0.026365935802459717,
-0.01067737489938736,
-0.022678473964333534,
-0.002681880258023739,
0.005654946435242891,
-0.0018738614162430167,
0.030743710696697235,
0.0025504357181489468,
0.0019035134464502335,
-0.013441499322652817,
0.032724715769290924,
-0.0002415529452264309,
-0.001512864138931036,
-0.007383943535387516,
-0.008671998977661133,
0.006586753763258457,
0.0019085193052887917,
0.009598160162568092,
-0.002708754036575556,
0.004720714874565601,
-0.004127148073166609,
0.07176733016967773,
-0.019047986716032028,
0.021567290648818016,
-0.0020998723339289427,
-0.0058122966438531876,
-0.005505689419806004,
0.004229781683534384,
-0.023678690195083618,
-0.006951599847525358,
-0.034055598080158234,
0.01619703881442547,
-0.014653347432613373,
-0.0006816633976995945,
0.009302005171775818,
0.01001265924423933,
0.006458099000155926,
-0.007008124142885208,
-0.011253336444497108,
0.0020983200520277023,
0.0030291303992271423,
-0.03377365320920944,
-0.01881229877471924,
-0.004452654626220465,
0.005437859334051609,
0.02557440474629402,
0.004034915007650852,
-0.043246783316135406,
-0.00405583530664444,
-0.017695710062980652,
0.012786515057086945,
-0.011178290471434593,
0.01900746300816536,
-0.0029843661468476057,
-0.0004320596344769001,
0.024979088455438614,
0.008071858435869217,
0.023204496130347252,
-0.002700406825169921,
0.007204016670584679,
0.009744565933942795,
-0.015155939385294914,
-0.00981724914163351,
0.0064195310696959496,
0.01145519595593214,
0.008756999857723713,
-0.0009650303982198238,
0.003813726594671607,
0.025638841092586517,
0.01239787694066763,
0.013788886368274689,
-0.007308592554181814,
-0.002250166842713952,
0.014695688150823116,
0.0015337998047471046,
-0.0038343651685863733,
-0.014815332368016243,
0.00170116126537323,
0.019737178459763527,
-0.0058484748005867004,
-0.028273897245526314,
0.0036442140117287636,
-0.017437290400266647,
0.017774639651179314,
-0.0075693633407354355,
0.013637462630867958,
-0.03509598597884178,
0.013087404891848564,
-0.012528751976788044,
-0.008030249737203121,
0.012924613431096077,
0.006443577818572521,
0.032218560576438904,
0.0018320102244615555,
0.0035473546013236046,
0.012190859764814377,
0.020420337095856667,
0.013233100064098835,
0.006291333585977554,
0.021005652844905853,
-0.0061029489152133465,
-0.01977936178445816,
-0.023210600018501282,
0.014064691960811615,
-0.001323365606367588,
0.02097932994365692,
-0.001225583953782916,
0.01306080725044012,
0.00425095297396183,
-0.011674432083964348,
0.004675653763115406,
0.00057071796618402,
0.00915550347417593,
-0.0023664154578000307,
0.007116332184523344,
0.00901765190064907,
0.03358885645866394,
0.014857916161417961,
-0.0003005804028362036,
0.0011787079274654388,
0.005693075712770224,
-0.00012289348524063826,
-0.004216261673718691,
0.019410595297813416,
0.0072753047570586205,
-0.009582459926605225,
0.0041684238240122795,
0.010366028174757957,
-0.008429041132330894,
-0.00554078072309494,
-0.0021803881973028183,
0.005934575106948614,
0.018064912408590317,
-0.008538061752915382,
-0.0029283135663717985,
0.007790401112288237,
0.005061272531747818,
-0.017961008474230766,
0.01267000287771225,
0.00019060075283050537,
-0.0028540240600705147,
-0.02009240910410881,
0.007844855077564716,
-0.022283870726823807,
0.026435382664203644,
-0.018024399876594543,
-0.014427472837269306,
-0.005467510316520929,
-0.013532922603189945,
-0.0038571609184145927,
-0.0152418352663517,
0.0018352868501096964,
-0.018549161031842232,
-0.018658829852938652,
0.0025078270118683577,
-0.000300705898553133,
0.0028004408814013004,
0.006113904528319836,
-0.012822974473237991,
0.005982006434351206,
0.012550403364002705,
-0.004928756505250931,
-0.017614921554923058,
0.004818994551897049,
-0.033609259873628616,
0.008311761543154716,
-0.010007013566792011,
0.02028898522257805,
0.006610570475459099,
0.01268464233726263,
0.010171993635594845,
-0.010485401377081871,
0.019532717764377594,
0.008925946429371834,
-0.0035008848644793034,
0.0010136698838323355,
0.012977740727365017,
0.0018198987236246467,
-0.01797313615679741,
-0.019346730783581734,
-0.0038697533309459686,
0.003737824037671089,
0.021741662174463272,
0.003770396113395691,
0.016120679676532745,
-0.007142080459743738,
0.009709351696074009,
0.024251988157629967,
0.03539459407329559,
-0.004940775688737631,
0.010186907835304737,
0.0009901283774524927,
-0.01429544948041439,
-0.01641204208135605,
0.01393851451575756,
-0.01983669400215149,
-0.02421691082417965,
-0.0038740718737244606,
0.005662417504936457,
-0.024190936237573624,
0.03356518968939781,
0.019501402974128723,
0.0025820257142186165,
0.022337868809700012,
-0.005161273293197155,
0.0011696608271449804,
0.007359826937317848,
-0.007349487394094467,
0.024359719827771187,
0.017110498622059822,
-0.003957950510084629,
-0.020731471478939056,
-0.0027018380351364613,
-0.018472470343112946,
0.004776854068040848,
-0.030875133350491524,
-0.04095778614282608,
0.005784036125987768,
-0.01169337797909975,
0.010282650589942932,
0.019719038158655167,
0.014934864826500416,
-0.005271164234727621
] | [
0.3274828791618347,
0.08022761344909668,
-0.2156577855348587,
0.04049152508378029,
0.14331255853176117,
-0.08943619579076767,
0.5657071471214294,
-0.09451279044151306,
-0.12177354097366333,
-0.8057131767272949,
0.0688185840845108,
0.3192984461784363,
-0.46177011728286743,
0.6107892990112305,
0.2331072837114334,
0.511097252368927,
0.3924700915813446,
0.42499780654907227,
-0.14272525906562805,
-0.17499740421772003,
-0.6316356062889099,
-0.2550298869609833,
-0.137264221906662,
0.12319109588861465,
0.24836944043636322,
-0.36834925413131714,
0.5169442892074585,
0.19095025956630707,
0.06392401456832886,
-0.16695605218410492,
0.23356813192367554,
0.3758099675178528,
-0.28763553500175476,
-0.27436038851737976,
-0.20531409978866577,
-0.05118817463517189,
-0.21006980538368225,
0.09451000392436981,
-0.3843783438205719,
-0.12881189584732056,
-0.42966973781585693,
0.09454572945833206,
-0.22971408069133759,
0.35141751170158386,
-0.28285539150238037,
-0.8948589563369751,
-1.2569799423217773,
0.3750806748867035,
0.0941748395562172,
-0.07462663948535919,
0.3372651934623718,
-0.008935609832406044,
-0.15903815627098083,
0.25599709153175354,
0.22151610255241394,
0.17055274546146393,
-0.44167399406433105,
-0.10631393641233444,
0.1103266030550003,
-0.3088795244693756,
-0.11690084636211395,
-0.40119633078575134,
-0.24800477921962738,
0.35016244649887085,
-0.16917288303375244,
0.4067886173725128,
0.428168922662735,
0.029551271349191666,
-0.5738231539726257,
-0.6415721774101257,
-0.25270184874534607,
-0.3919314444065094,
-0.005972139537334442,
0.04861029237508774,
-0.24059417843818665,
-0.39546507596969604,
0.09230440109968185,
-0.6700363159179688,
0.06312619894742966,
0.14926716685295105,
0.01879580318927765,
0.17386920750141144,
0.07179146260023117,
-0.726499617099762,
0.7971199154853821,
0.08654802292585373,
0.17471428215503693,
1.0293521881103516,
-0.24941618740558624,
0.24203048646450043,
0.5994096398353577,
0.020456673577427864,
0.4202069640159607,
-0.045427557080984116,
0.3453289866447449,
0.5562961101531982,
0.490357905626297,
0.11789570748806,
-0.2765105068683624,
0.1871701180934906,
0.0819813534617424,
-0.3395604193210602,
0.023987293243408203,
-0.40549570322036743,
-0.21642522513866425,
-0.6559869050979614,
-0.21849662065505981,
-0.5468804240226746,
-0.34184718132019043,
0.307612806558609,
-0.26329514384269714,
0.4710908830165863,
0.053506359457969666,
-0.11784965544939041,
-0.5767641663551331,
0.3362398147583008,
0.18328674137592316,
-0.397887259721756,
0.0787711814045906,
-0.16304628551006317,
0.34370726346969604,
0.9732767343521118,
-0.19123093783855438,
0.21608677506446838,
-0.08148612082004547,
0.023728296160697937,
0.7704852819442749,
-0.006856005173176527,
-0.25321611762046814,
0.33101314306259155,
-0.012535268440842628,
0.7505970597267151,
-0.5093990564346313,
-0.3755583167076111,
-0.1689484715461731,
0.002406677696853876,
-0.35383254289627075,
0.5830720663070679,
0.18895597755908966,
-0.14335106313228607,
-0.351159006357193,
-0.887779176235199,
-0.05660751461982727,
0.10016729682683945,
0.024426789954304695,
0.059829361736774445,
-0.25133806467056274,
-0.1370236724615097,
0.00861651822924614,
-0.2012932002544403,
0.10615168511867523,
0.03226732090115547,
-0.8622652292251587,
0.4793147146701813,
0.003862139070406556,
0.3937416076660156,
0.21616359055042267,
-0.28473034501075745,
-0.04749862104654312,
0.2145271748304367,
0.6546081304550171,
-0.00173470180016011,
-0.29101642966270447,
-0.16587597131729126,
0.3352404236793518,
-0.15305407345294952,
-0.17283467948436737,
0.5634486079216003,
0.09696745127439499,
-0.4254889488220215,
-0.5479059219360352,
-0.0211435966193676,
-0.049570705741643906,
-0.7829914093017578,
0.2950747013092041,
-0.22271887958049774,
0.23690661787986755,
0.012635643593966961,
0.15831561386585236,
0.1419234424829483,
-0.48004892468452454,
-0.12488066405057907,
-0.06687244772911072,
-0.550662636756897,
0.29444828629493713,
-0.1398136019706726,
0.08826477080583572,
-0.06405626237392426,
-0.030702894553542137,
-0.1851673275232315,
-0.545417308807373,
-0.2924979031085968,
0.4623945951461792,
-0.573427677154541,
0.9792916178703308,
-0.34983810782432556,
-0.04843929409980774,
1.7341148853302002,
0.07398277521133423,
-0.2752101421356201,
-0.02175847813487053,
0.10861243307590485,
0.24979692697525024,
0.056249022483825684,
-1.0649199485778809,
-0.014815213158726692,
0.22888042032718658,
-0.2301296442747116,
-0.45375916361808777,
0.20179906487464905,
0.9533836245536804,
-0.6143001317977905,
-0.2551615238189697,
-0.6265395879745483,
0.08285654336214066,
0.10814356803894043,
-0.34878283739089966,
0.09214440733194351,
-0.3934992551803589,
0.12476112693548203,
0.42975151538848877,
-0.7106359601020813,
0.353498250246048,
0.793601393699646,
0.4052550494670868,
0.347896546125412,
0.3536142408847809,
0.08149019628763199,
0.8491839170455933,
-0.7656465768814087,
0.3501104414463043,
-0.36605823040008545,
0.6383598446846008,
-0.49296241998672485,
-0.509766697883606,
0.27817022800445557,
-0.2284681648015976,
-0.049021486192941666,
-0.24220483005046844,
-0.033958032727241516,
0.1374332755804062,
0.27286496758461,
-0.6076343655586243,
0.739855170249939,
-0.13067181408405304,
-0.21300415694713593,
-0.11242036521434784,
-0.02049335092306137,
-0.5519333481788635,
0.12294617295265198,
0.3534930944442749,
0.5087846517562866,
0.3897378742694855,
-0.5448658466339111,
0.3676815330982208,
0.0454164519906044,
-0.0009560513426549733,
-0.1906457394361496,
0.1636645793914795,
-0.5177920460700989,
-0.19546906650066376,
0.2442779541015625,
0.15657015144824982,
0.1552884876728058,
0.024367762729525566,
-0.38794654607772827,
-0.43969008326530457,
-0.5747208595275879,
0.21127283573150635,
0.8808718919754028,
0.9065686464309692,
-0.19403286278247833,
-0.6394719481468201,
-0.11455769091844559,
0.15185502171516418,
-0.7287645936012268,
0.38684743642807007,
0.9929068088531494,
-0.5585964322090149,
0.24969841539859772,
-0.02536029741168022,
0.3689213991165161,
0.5137072205543518,
-0.5281125903129578,
-0.4211462438106537,
-0.2852461040019989,
0.41897594928741455,
-0.37544888257980347,
-0.6472075581550598,
0.2453039288520813,
-0.46692267060279846,
-0.05242012441158295,
-0.28325119614601135,
-0.18655869364738464,
0.22190967202186584,
-0.11739427596330643,
-0.19174261391162872,
0.4043428599834442,
0.49252164363861084,
-0.2743515074253082,
-0.24887113273143768,
0.5203052163124084,
0.002176741138100624,
-0.17205344140529633,
-0.28710633516311646,
0.2292391061782837,
-0.3383948802947998,
0.2527211606502533,
-5.977758884429932,
-0.6459272503852844,
-0.018604742363095284,
-0.22028140723705292,
-0.527891993522644,
0.09343378990888596,
1.2031244039535522,
-0.14081524312496185,
0.19656771421432495,
-0.04305506497621536,
0.7632733583450317,
0.5547980666160583,
0.32858806848526,
-0.15422023832798004,
0.0447569377720356,
0.06669308245182037,
0.2544761300086975,
-0.08702358603477478,
0.12856924533843994,
0.2861658036708832,
0.296083003282547,
0.16557802259922028,
-0.048342760652303696,
0.6732490658760071,
0.2653661370277405,
-0.11644548177719116,
-0.8287174105644226,
0.24558484554290771,
-0.126456618309021,
-0.0010481139179319143,
0.44644695520401,
-0.30319008231163025,
-0.21828943490982056,
-0.4239889681339264,
0.012440133839845657,
0.12906745076179504,
-0.138544499874115,
-0.015393110923469067,
-0.2275296151638031,
-0.40061166882514954,
-0.04437960684299469,
0.1335313320159912,
-0.16851113736629486,
0.07478415966033936,
-0.0412234403192997,
-0.12945465743541718,
0.11343139410018921,
0.3117837607860565,
-0.3831873834133148,
0.8103650212287903,
-0.05142746493220329,
-0.004257673397660255,
0.4391818344593048,
0.37547215819358826,
-0.053865525871515274,
-0.08427245914936066,
0.14212562143802643,
0.1360257863998413,
-0.6845239996910095,
0.04944022372364998,
-0.1837872415781021,
-0.40704214572906494,
0.2045014351606369,
-0.18806077539920807,
0.20860517024993896,
0.1804240643978119,
-0.38269829750061035,
-1.1153292655944824,
0.24261364340782166,
-0.006574858445674181,
-0.3574199378490448,
0.2122759222984314,
0.43741491436958313,
-0.6447063088417053,
-0.07427936047315598,
-0.30277541279792786,
0.16399632394313812,
0.22453081607818604,
0.22153891623020172,
-0.6524807214736938,
-0.9211804270744324,
-0.11860307306051254,
0.11143806576728821,
-0.19094671308994293,
0.6424888968467712,
-0.3353084623813629,
-0.17241360247135162,
0.04900655522942543,
-0.17392155528068542,
0.24956417083740234,
0.37633585929870605,
-0.34198784828186035,
0.46648114919662476,
0.16534334421157837,
0.2485835999250412,
1.1931278705596924,
0.31994158029556274,
0.15428490936756134,
0.32326874136924744,
-0.1913251131772995,
0.5499699115753174,
-0.18732044100761414,
-0.015002510510385036,
-0.9428726434707642,
-0.14312639832496643,
-0.06550164520740509,
-0.06449104845523834,
0.4136505722999573,
0.7834942936897278,
-1.0331900119781494,
0.26132938265800476,
0.22773289680480957,
-0.04154403135180473,
-0.39655667543411255,
0.3045450448989868,
-0.40408116579055786,
0.12705548107624054,
0.5649264454841614,
0.3313330411911011,
0.014131233096122742,
0.43723800778388977,
0.2887713313102722,
-0.4157648980617523,
0.46844610571861267,
0.31361061334609985,
-0.2888173460960388,
0.0932324081659317,
0.7385597229003906,
-0.21805642545223236,
-0.3845917582511902,
0.22878995537757874,
0.5789355039596558,
-0.23545169830322266,
-0.016649004071950912,
0.32972434163093567,
-0.22183483839035034,
0.03186136484146118,
0.054299868643283844,
0.09083245694637299,
-0.4020717442035675,
0.14706182479858398,
0.045187532901763916,
-0.41717618703842163,
0.17349465191364288,
-0.22736293077468872,
0.014445182867348194,
-0.07395874708890915,
0.1955002397298813,
0.09452158957719803,
0.03470857813954353,
-0.24501332640647888,
0.28719788789749146,
-0.07120311260223389,
-0.2780320346355438,
-0.476194828748703,
0.4257444739341736,
0.6837046146392822,
-0.09241403639316559,
0.15521608293056488,
-0.5529119372367859,
0.25932246446609497,
-0.008706615306437016,
-1.0140948295593262,
-0.26697927713394165,
0.3440600335597992,
0.1358962208032608,
-0.06849449127912521,
-0.201957106590271,
0.0040289657190442085,
0.7059214115142822,
-0.25540927052497864,
-0.2914314270019531,
-0.5429469347000122,
0.026099806651473045,
0.04351047798991203,
-0.14752863347530365,
-0.4758355915546417,
0.16734610497951508,
-0.2282589226961136,
0.1594327837228775,
0.2547447383403778,
-0.7590123414993286,
-0.4738084673881531,
0.3378020226955414,
0.07528283447027206,
0.3574983775615692,
-0.02536780759692192,
-0.37372732162475586,
-0.5406792759895325,
-0.4493136703968048,
-0.13259731233119965,
0.4620487689971924,
0.2327081561088562,
-0.16202598810195923,
0.17174920439720154,
-0.1824669986963272,
-0.26366108655929565,
0.09214115142822266,
0.23811618983745575,
-0.12130269408226013,
0.253529816865921,
0.4110577702522278,
-0.6574022769927979,
0.2745833694934845,
0.1915237307548523,
-0.36344507336616516,
0.07476027309894562,
0.05489463731646538,
0.09445478022098541,
0.06014963984489441,
-0.3862628936767578,
-0.262647807598114,
0.20013074576854706,
0.6276576519012451,
-0.30369025468826294,
0.06226915493607521,
-0.01891370117664337,
-0.40344756841659546,
-0.12748417258262634,
0.46058574318885803,
0.21711789071559906,
-0.11196766793727875,
-0.12410836666822433,
-0.15854832530021667,
-0.3812996447086334,
0.29002952575683594,
0.46966785192489624,
-0.6933004856109619,
0.11888416856527328,
0.32863956689834595,
-0.419700026512146,
-0.19092823565006256,
0.30819785594940186,
0.06221332773566246,
-0.44345560669898987,
-0.448066383600235,
0.12582722306251526,
0.1791243553161621,
0.0950305163860321,
0.15187950432300568,
0.060390252619981766,
0.28251293301582336,
-0.2328978180885315,
-0.7860937118530273,
-0.014761731028556824,
0.09661153703927994,
0.45542359352111816,
-0.5544202923774719,
-0.5931820273399353,
0.13483552634716034,
-0.03685678541660309,
-0.06062505021691322,
-0.22498860955238342,
0.05099485069513321,
0.6239005923271179,
0.39597374200820923,
-0.09058849513530731,
0.025898750871419907,
-0.1173219233751297,
-0.0723223015666008,
0.1196659505367279,
-0.14031170308589935,
-0.309558629989624,
-0.3275025188922882,
0.8120084404945374,
-0.18601462244987488,
-0.6424935460090637,
-0.6259688138961792,
0.2813090682029724,
-0.6175333857536316,
-0.012067372910678387,
-0.09297079592943192,
0.8316559791564941,
0.401027113199234,
0.3738299012184143,
0.03738027438521385,
-0.07337221503257751,
-0.061472661793231964,
-0.23111839592456818,
0.47549939155578613,
0.05567852035164833,
-0.38463935256004333,
0.32547518610954285,
-0.46836334466934204,
0.3881336748600006,
-0.6544521450996399,
0.24407733976840973,
-0.14894871413707733,
0.22194203734397888,
-0.5617521405220032,
-0.4925527572631836,
0.11040163785219193,
-0.933096706867218,
-0.14915823936462402,
-0.21674679219722748,
0.22078771889209747,
0.34700170159339905,
0.2631036639213562,
0.26670876145362854,
-0.47118452191352844,
-0.5293769240379333,
0.6257911920547485,
0.3077712655067444,
-0.3997170925140381,
0.2577893137931824,
0.3779636323451996,
0.16141851246356964,
0.6302422285079956,
-0.06598853319883347,
0.3310616910457611,
0.2631809711456299,
0.06642995774745941,
0.36676713824272156,
0.885659396648407,
-0.07552240788936615,
0.463533878326416,
-0.1329493224620819,
-0.025722693651914597,
0.5867820382118225,
0.007141740992665291,
0.21025323867797852,
0.14871662855148315,
0.3859492242336273,
0.042356446385383606,
-0.5648077726364136,
0.7151412963867188,
-0.26651766896247864,
0.25657397508621216,
0.073096863925457,
0.4130306839942932,
0.36079075932502747,
0.5565162301063538,
-0.29485371708869934,
0.3196370601654053,
-0.03699313476681709,
0.2640937566757202,
0.3709149956703186,
-0.7650463581085205,
-0.48896151781082153,
-0.07732279598712921,
0.926529049873352,
-0.026185499504208565,
0.029878564178943634,
0.08941347897052765,
-0.4326496124267578,
0.5012537240982056,
0.16671110689640045,
0.3462747037410736,
-0.5086961388587952,
0.16603051126003265,
0.3632463812828064,
-0.0027371367905288935,
-0.34644368290901184,
0.327203631401062,
-0.12611691653728485,
-0.018742715939879417,
0.5549868941307068,
-0.6514430642127991,
-0.14916472136974335,
0.230972558259964,
0.024858830496668816,
0.10584653168916702,
-0.09010525792837143,
0.39328256249427795,
0.10261214524507523,
0.1785210222005844,
0.8280935287475586,
0.09306943416595459,
0.14360548555850983,
-0.17715923488140106,
-0.19762900471687317,
-0.3320171535015106,
-0.16591060161590576,
0.5694211721420288,
0.35209015011787415,
-0.5367994904518127,
-0.059552744030952454,
-0.26896610856056213,
-0.07930654287338257,
0.21389468014240265,
-0.37948065996170044,
0.06052406504750252,
-0.11012718826532364,
-0.2945912778377533,
-0.23093929886817932,
-0.22454003989696503,
-0.7918041944503784,
-0.07563208043575287,
0.3073796033859253,
0.2667742073535919,
0.07483434677124023,
-0.4185645580291748,
-0.21194303035736084,
0.242080956697464,
0.10163412988185883,
-0.3891209363937378,
0.16404731571674347,
0.6648456454277039,
-0.19628116488456726,
0.16751791536808014,
-0.1325562298297882,
0.031088797375559807,
-0.4908837676048279,
0.5545365810394287,
-0.6418604254722595,
0.38106223940849304,
-0.37428736686706543,
0.33241817355155945,
-0.7177143692970276,
0.04770243167877197,
0.49444228410720825,
0.33946749567985535,
-0.34677571058273315,
0.09581105411052704,
-0.24131332337856293,
0.012355037033557892,
0.012467161752283573,
-0.400974303483963,
0.009493988938629627,
-0.53520667552948,
0.12083395570516586,
-0.4484498202800751,
0.3456569314002991,
-0.038602955639362335,
-0.2230575531721115,
-0.3158198893070221,
0.21554508805274963,
0.5356797575950623,
-0.35324859619140625,
0.46321049332618713,
-0.3352143168449402,
0.024639002978801727,
-0.5440099239349365,
0.17976146936416626,
-0.5988320112228394,
0.11387880146503448,
0.2832496166229248,
0.26619142293930054,
0.4683779180049896,
-0.10969515144824982,
-0.030272698029875755,
-0.4598671495914459,
0.45213180780410767,
0.4377943277359009,
0.1830010563135147,
-0.10006705671548843,
-0.1477130651473999,
-0.26232561469078064,
-0.09315390139818192,
0.8230991363525391,
-0.12384337931871414,
0.13457199931144714,
-0.1784801334142685,
0.12237140536308289,
-0.2588542103767395,
0.1657676100730896,
0.1702844351530075,
-0.5176997780799866,
-0.19303090870380402,
-0.20067785680294037
] |
Rotaviruses are the leading cause of severe dehydrating diarrhea in children worldwide. Rotavirus-induced immune responses, especially the T and B cell responses, have been extensively characterized; however, little is known about innate immune mechanisms involved in the control of rotavirus infection. Although increased levels of systemic type I interferon (IFNα and β) correlate with accelerated resolution of rotavirus disease, multiple rotavirus strains, including rhesus rotavirus (RRV), have been demonstrated to antagonize type I IFN production in a variety of epithelial and fibroblast cell types through several mechanisms, including degradation of multiple interferon regulatory factors by a viral nonstructural protein. This report demonstrates that stimulation of highly purified primary human peripheral plasmacytoid dendritic cells (pDCs) with either live or inactivated RRV induces substantial IFNα production by a subset of pDCs in which RRV does not replicate. Characterization of pDC responses to viral stimulus by flow cytometry and Luminex revealed that RRV replicates in a small subset of human primary pDCs and, in this RRV-permissive small subset, IFNα production is diminished. pDC activation and maturation were observed independently of viral replication and were enhanced in cells in which virus replicates. Production of IFNα by pDCs following RRV exposure required viral dsRNA and surface proteins, but neither viral replication nor activation by trypsin cleavage of VP4. These results demonstrate that a minor subset of purified primary human peripheral pDCs are permissive to RRV infection, and that pDCs retain functionality following RRV stimulus. Additionally, this study demonstrates trypsin-independent infection of primary peripheral cells by rotavirus, which may allow for the establishment of extraintestinal viremia and antigenemia. Importantly, these data provide the first evidence of IFNα induction in primary human pDCs by a dsRNA virus, while simultaneously demonstrating impaired IFNα production in primary human cells in which RRV replicates. Rotavirus infection of primary human pDCs provides a powerful experimental system for the study of mechanisms underlying pDC-mediated innate immunity to viral infection and reveals a potentially novel dsRNA-dependent pathway of IFNα induction. | [
-0.0005761687061749399,
0.00658357422798872,
-0.020736366510391235,
0.01603836379945278,
0.004033494740724564,
0.002566672395914793,
0.008678268641233444,
0.04400474950671196,
-0.012417446821928024,
-0.006100518628954887,
-0.005839580204337835,
0.012582283467054367,
-0.023947611451148987,
0.016906367614865303,
-0.014304034411907196,
-0.0017874469049274921,
0.0193877425044775,
0.017715223133563995,
0.007353323511779308,
0.001764968503266573,
-0.002960961079224944,
0.0020746313966810703,
0.010140432976186275,
-0.005408706143498421,
-0.0012915183324366808,
0.004894278012216091,
-0.006480220705270767,
-0.024215111508965492,
0.010952835902571678,
0.013122223317623138,
-0.0015044072642922401,
0.011853571981191635,
0.00441526947543025,
0.027618933469057083,
0.0018455120734870434,
-0.004530241712927818,
-0.003984568174928427,
0.02252872660756111,
0.027079056948423386,
-0.004217139445245266,
0.0059838066808879375,
-0.005129321478307247,
0.006834426894783974,
-0.01224684901535511,
-0.0034137291368097067,
-0.04555294290184975,
-0.000439831695985049,
-0.000024951761588454247,
-0.0008182814344763756,
0.004265197552740574,
-0.02175242081284523,
0.020783208310604095,
-0.005981183610856533,
0.005401815753430128,
-0.006313723511993885,
0.027287758886814117,
0.01707129366695881,
-0.008187186904251575,
-0.0207328163087368,
0.014677435159683228,
0.006518181413412094,
-0.0076946234330534935,
-0.018470928072929382,
-0.01775284856557846,
0.0193819310516119,
-0.06702356040477753,
-0.0016101065557450056,
-0.008614174090325832,
0.006362193264067173,
-0.0047416966408491135,
0.00989447720348835,
0.004680876154452562,
-0.01279254537075758,
0.021467534825205803,
-0.03691156208515167,
-0.0009627642575651407,
-0.0036018702667206526,
-0.0005946899764239788,
0.04368046671152115,
-0.0045042699202895164,
0.008039100095629692,
0.0053696343675255775,
0.024932527914643288,
0.01885506883263588,
0.018704555928707123,
0.011533524841070175,
-0.02400892600417137,
-0.019292641431093216,
-0.016305601224303246,
-0.006285001523792744,
-0.003142561763525009,
-0.006612291559576988,
-0.035844843834638596,
0.019176525995135307,
-0.021524924784898758,
-0.012542502954602242,
-0.010767318308353424,
-0.008447656407952309,
0.0004248404875397682,
-0.01592789590358734,
-0.01670101284980774,
-0.00243556359782815,
0.013253100216388702,
-0.005757382605224848,
0.01334438007324934,
0.004183371551334858,
-0.0010764847975224257,
0.01795879565179348,
0.011291923001408577,
0.011967811733484268,
-0.00005702150519937277,
-0.017832092940807343,
0.009171847254037857,
0.019835498183965683,
-0.007922821678221226,
-0.018991224467754364,
-0.005077746696770191,
0.01771324872970581,
0.006753052584826946,
0.015380801633000374,
0.025121860206127167,
-0.023011010140180588,
-0.005813589319586754,
-0.0016093195881694555,
0.0005405034171417356,
0.0036035566590726376,
-0.01200083177536726,
0.010530558414757252,
0.01603947952389717,
0.019543375819921494,
-0.006263336166739464,
0.00984656997025013,
-0.004012139514088631,
-0.0336199514567852,
-0.0007393374107778072,
-0.002635139273479581,
0.012979425489902496,
-0.018281947821378708,
-0.002258912194520235,
-0.028965679928660393,
-0.01872050017118454,
0.006270761601626873,
0.0047322530299425125,
0.012208479456603527,
-0.01383383758366108,
0.0120657067745924,
0.016059955582022667,
0.0019783368334174156,
0.02691064588725567,
-0.004879782907664776,
-0.0035764281637966633,
0.0021982446778565645,
-0.001668125274591148,
-0.0014462696854025126,
-0.0008416674099862576,
0.018712859600782394,
-0.015274048782885075,
-0.03546658158302307,
-0.0016036212909966707,
0.013326328247785568,
0.011146683245897293,
0.004072790965437889,
0.021076489239931107,
0.008324186317622662,
-0.0006975824944674969,
0.007810263428837061,
0.028527455404400826,
-0.024567626416683197,
-0.009695304557681084,
0.007213706150650978,
0.0023434306494891644,
-0.024043094366788864,
0.012358986772596836,
0.01078554056584835,
0.015424158424139023,
0.004379519261419773,
-0.019311362877488136,
0.007039200980216265,
-0.005105707794427872,
0.06637387722730637,
0.024440081790089607,
-0.0026649830397218466,
0.0070748403668403625,
-0.00018289592117071152,
0.013401184231042862,
-0.017162660136818886,
0.03354854881763458,
-0.014064684510231018,
-0.0050069293938577175,
-0.032188232988119125,
-0.006784465629607439,
-0.014466419816017151,
-0.01727651059627533,
-0.037340786308050156,
0.0022719837725162506,
0.003798332531005144,
0.024506453424692154,
0.0050826966762542725,
0.009397185407578945,
0.01709403656423092,
0.007471862714737654,
0.000483890064060688,
0.03706580400466919,
0.005066245328634977,
-0.027950052171945572,
-0.0011749420082196593,
-0.004249650053679943,
-0.011027542874217033,
0.0003016623668372631,
-0.01844727247953415,
0.012097625061869621,
0.015023882500827312,
0.003953357692807913,
-0.016021857038140297,
0.019290704280138016,
-0.009486498311161995,
0.005141120404005051,
0.0028534983284771442,
-0.0022454301360994577,
-0.016119496896862984,
-0.0008184512844309211,
0.021273065358400345,
-0.022493071854114532,
-0.017184551805257797,
0.0045454241335392,
0.017343878746032715,
0.0025718947872519493,
0.0114924106746912,
-0.018459441140294075,
-0.0025955215096473694,
-0.004789097234606743,
-0.02206169068813324,
-0.007506377063691616,
0.010284053161740303,
-0.009584068320691586,
-0.013926743529736996,
0.013865332119166851,
-0.021269703283905983,
0.020990554243326187,
-0.018084146082401276,
-0.02230563759803772,
0.001555269816890359,
0.020710797980427742,
0.00029174238443374634,
-0.009764168411493301,
0.020872555673122406,
-0.0021559610031545162,
0.010277186520397663,
0.0023503685370087624,
-0.02215464599430561,
0.010919691994786263,
-0.0004066965775564313,
-0.004408429376780987,
-0.004703414626419544,
0.005413268692791462,
0.017569443210959435,
0.044178206473588943,
-0.025017596781253815,
0.025264957919716835,
-0.0023018072824925184,
0.020423486828804016,
0.003950549755245447,
0.010699406266212463,
-0.0058410754427313805,
-0.012861165218055248,
0.01821299083530903,
0.00036785833071917295,
0.004418700002133846,
0.013745976611971855,
0.0089070163667202,
0.005685477517545223,
-0.0067827822640538216,
-0.010321453213691711,
-0.08195257931947708,
-0.004040044732391834,
0.009505921974778175,
-0.026865260675549507,
0.0015864737797528505,
-0.016800757497549057,
-0.008056030608713627,
0.019293032586574554,
-0.005999072454869747,
0.02941161021590233,
0.009458890184760094,
0.023650003597140312,
0.000703805242665112,
0.004248105455189943,
-0.02303013950586319,
-0.0037540963385254145,
0.009121142327785492,
-0.007389779668301344,
-0.02679622545838356,
-0.02070392668247223,
-0.012830263003706932,
-0.0047748032957315445,
0.007213677745312452,
-0.004152841400355101,
-0.006306310184299946,
0.009181360714137554,
0.004716572817414999,
0.01138993352651596,
-0.01576864905655384,
0.007280526217073202,
0.005890303291380405,
-0.0003345230361446738,
0.032837625592947006,
0.024477198719978333,
0.054186172783374786,
0.006634012330323458,
0.0036332353483885527,
-0.029817285016179085,
-0.01291330624371767,
-0.006525917910039425,
-0.009465842507779598,
0.017406266182661057,
0.0044042933732271194,
0.007370276376605034,
0.018126502633094788,
0.007945351302623749,
-0.005980662535876036,
0.02547055296599865,
0.016355056315660477,
-0.017433475703001022,
-0.011297868564724922,
-0.005342166405171156,
0.01258138194680214,
0.014189418405294418,
0.004723307676613331,
-0.01685844361782074,
-0.02048427239060402,
-0.0039893342182040215,
-0.007568417116999626,
-0.01104743592441082,
-0.014853991568088531,
-0.006574502680450678,
0.0028007840737700462,
0.023948414251208305,
-0.025175897404551506,
0.02127787284553051,
0.016411220654845238,
0.022437041625380516,
-0.010690431110560894,
0.014443370513617992,
-0.009428529068827629,
0.009254466742277145,
-0.026555117219686508,
-0.009539235383272171,
-0.006523705553263426,
-0.0004083262465428561,
-0.007440002169460058,
-0.005620917771011591,
0.009039762429893017,
-0.0013861358165740967,
-0.023785140365362167,
0.009325709193944931,
0.014154328033328056,
0.007634381763637066,
-0.028225112706422806,
-0.004122855141758919,
0.0031608683057129383,
0.020093826577067375,
0.01876106485724449,
-0.017992321401834488,
0.039233043789863586,
0.00328050903044641,
-0.017558125779032707,
0.014437452889978886,
-0.0065731448121368885,
-0.006550987716764212,
-0.007625605445355177,
0.000025264453142881393,
0.002391437068581581,
0.009141531772911549,
-0.036880578845739365,
-0.007238880265504122,
-0.0161319300532341,
-0.0007017322350293398,
-0.030853230506181717,
0.01823199912905693,
0.009925704449415207,
0.0018163489876314998,
0.004845202900469303,
-0.0018172594718635082,
0.021124575287103653,
-0.0023329737596213818,
-0.00963047705590725,
0.026135127991437912,
0.007186997681856155,
-0.016985226422548294,
0.0026798013132065535,
-0.031774017959833145,
0.07243245840072632,
-0.013186097145080566,
0.0006339040701277554,
-0.0003917430294677615,
0.010257028043270111,
-0.0035961647517979145,
-0.013921236619353294,
0.0007317940471693873,
-0.008447264321148396,
0.018136272206902504,
0.012639290653169155,
-0.02494579739868641,
-0.0239048283547163,
0.010591594502329826,
0.006360319443047047,
-0.026209160685539246,
0.016790185123682022,
-0.017999662086367607,
0.043022267520427704,
0.009491531178355217,
0.020191043615341187,
-0.03940913826227188,
-0.017558369785547256,
-0.013153664767742157,
0.02025359869003296,
0.012330295518040657,
-0.012512808665633202,
-0.013207857497036457,
-0.0013123768148943782,
0.004813287872821093,
-0.012965512461960316,
0.008905461989343166,
-0.0044129397720098495,
-0.008394880220293999,
0.006329820957034826,
-0.018975574523210526,
0.019876521080732346,
-0.02216525375843048,
0.01789470948278904,
-0.020328637212514877,
-0.03899334371089935,
-0.016549181193113327,
0.00035437196493148804,
0.006137328688055277,
-0.015156779438257217,
0.023066446185112,
0.0185613464564085,
-0.006570653058588505,
-0.015268536284565926,
-0.020116033032536507,
-0.010153058916330338,
0.0089363232254982,
0.005447680130600929,
0.01008231658488512,
-0.007810714654624462,
-0.017953097820281982,
0.01380867324769497,
-0.002113721799105406,
0.014235669746994972,
-0.01689457707107067,
0.015260344371199608,
0.0007480914937332273,
0.013000301085412502,
-0.0195118710398674,
0.007621707394719124,
-0.012274420820176601,
-0.01848767325282097,
0.0020171967335045338,
0.007290259003639221,
-0.024072103202342987,
-0.011758568696677685,
-0.02915848232805729,
0.004617706406861544,
0.020756125450134277,
-0.021578822284936905,
-0.0018103353213518858,
-0.038838066160678864,
-0.02131553739309311,
0.01183551736176014,
-0.01774819940328598,
-0.020183015614748,
-0.0006456440314650536,
-0.0009918003343045712,
-0.00863442663103342,
0.018493518233299255,
0.0017897184006869793,
-0.021653153002262115,
-0.07520981132984161,
0.0017847437411546707,
0.001392508391290903,
-0.007168773096054792,
0.0037551792338490486,
0.023346764966845512,
-0.010767408646643162,
-0.0028171446174383163,
-0.01867884024977684,
-0.01732170768082142,
-0.0072810035198926926,
-0.0019535340834409,
-0.015079272910952568,
-0.009857147000730038,
0.013225558213889599,
-0.00016317376866936684,
-0.00734103424474597,
0.007813502103090286,
-0.015768148005008698,
-0.009216327220201492,
0.019210221245884895,
-0.003842652076855302,
-0.026563387364149094,
0.004523342475295067,
0.00033691455610096455,
-0.08132743090391159,
-0.004251214675605297,
0.012624446302652359,
-0.007001523394137621,
-0.006234049331396818,
-0.008068479597568512,
0.010932756587862968,
-0.01934429258108139,
0.026592917740345,
-0.01778649352490902,
-0.0036441790871322155,
-0.020253853872418404,
0.013694430701434612,
-0.021435778588056564,
0.02112954668700695,
-0.0131898308172822,
0.00755053898319602,
-0.0003448436036705971,
0.02337382733821869,
-0.012231322005391121,
-0.012434586882591248,
-0.001486080582253635,
-0.0070768543519079685,
-0.010275855660438538,
-0.0048639061860740185,
-0.031689293682575226,
-0.005743850953876972,
0.007764363661408424,
-0.00890333205461502,
-0.01455079298466444,
-0.007041210308670998,
-0.010967238806188107,
-0.009956171736121178,
-0.021438924595713615,
0.02383599989116192,
-0.011058197356760502,
0.006427604705095291,
0.010249979794025421,
0.024075264111161232,
-0.002835846273228526,
-0.00892055593430996,
-0.0106987114995718,
-0.011574959382414818,
0.007860167883336544,
-0.000607107300311327,
-0.025449788197875023,
0.00968913547694683,
-0.009022137150168419,
0.007083491422235966,
-0.03356892615556717,
0.013144467957317829,
-0.04022222384810448,
-0.008004305884242058,
-0.014756307937204838,
0.017854824662208557,
0.005043915472924709,
-0.006840151734650135,
0.01139901764690876,
-0.009447791613638401,
0.013535279780626297,
-0.006106184329837561,
0.015354076400399208,
0.019687563180923462,
0.0715617686510086,
-0.015053706243634224,
0.014570173807442188,
-0.029456453397870064,
0.015433171764016151,
0.005417549051344395,
-0.004371988121420145,
0.005808007903397083,
0.006785595789551735,
-0.030997226014733315,
-0.011657929047942162,
-0.016309021040797234,
-0.0027918799314647913,
0.011610254645347595,
-0.009996398352086544,
0.018039098009467125,
0.00022037513554096222,
0.013506582006812096,
-0.0008163508027791977,
0.016882669180631638,
0.0022743886802345514,
0.002800017362460494,
0.004041741602122784,
-0.0016496963798999786,
0.003628284903243184,
0.002150454092770815,
-0.013859937898814678,
-0.011745122261345387,
-0.027339037507772446,
0.028156688436865807,
0.011483327485620975,
-0.014846145175397396,
0.004259997978806496,
-0.009037718176841736,
0.0013552133459597826,
-0.0037012724205851555,
-0.014830514788627625,
0.005850448273122311,
-0.021364834159612656,
0.005201251246035099,
0.01345845963805914,
0.01574920490384102,
0.0021377569064497948,
0.0009891162626445293,
0.007318618707358837,
-0.011729098856449127,
0.00967540591955185,
0.010635034181177616,
0.03624817728996277,
0.008847497403621674,
0.0027834069915115833,
-0.0009234645403921604,
0.02410721220076084,
-0.005119672045111656,
0.002374115400016308,
0.024086523801088333,
-0.024501442909240723,
0.017795903608202934,
-0.011364806443452835,
-0.004511816427111626,
-0.010984948836266994,
-0.013962674885988235,
0.015709705650806427,
-0.02362236939370632,
-0.0015534715494140983,
-0.025728821754455566,
-0.010797372087836266,
-0.016586728394031525,
-0.03343422710895538,
0.009945444762706757,
-0.017997123301029205,
0.010727813467383385,
0.0070771751925349236,
0.013143906369805336,
0.03722379729151726,
0.019777320325374603,
0.031627148389816284,
-0.013345327228307724,
0.014781426638364792,
0.0018177090678364038,
-0.009922444820404053,
-0.0031824836041778326,
-0.005106532946228981,
0.004830094985663891,
0.007714960724115372,
-0.018817545846104622,
0.007126651704311371,
-0.023708190768957138,
-0.0044712889939546585,
0.0067385355941951275,
0.009354689158499241,
0.006297142244875431,
0.011115316301584244,
-0.012484419159591198,
0.006701068952679634,
0.03495156764984131,
0.017259521409869194,
0.004153790883719921,
-0.008638300001621246,
-0.011454425752162933,
-0.007132254540920258,
-0.010744620114564896,
-0.002721992088481784,
0.0027611670084297657,
0.016800373792648315,
-0.0004197441739961505,
0.0018827853491529822,
-0.003759977873414755,
-0.009831840172410011,
0.015414731577038765,
0.026141496375203133,
0.012708470225334167,
0.010066271759569645,
-0.00008654792327433825,
0.0009515663841739297,
0.0029998638201504946,
-0.006115095689892769,
-0.03336242958903313,
0.022480178624391556,
-0.008044155314564705,
0.030528299510478973,
-0.0004702929873019457,
0.017849557101726532,
0.019932903349399567,
-0.007230333983898163,
-0.015715979039669037,
-0.012647602707147598,
-0.04721834510564804,
0.0015695466427132487,
0.005631767213344574,
0.01239423081278801,
-0.012913967482745647,
-0.014291147701442242,
0.002522667171433568,
-0.01426155585795641,
-0.0003070943057537079,
0.006734371650964022,
-0.02916073054075241,
-0.0033152552787214518,
0.016381632536649704,
-0.005746488459408283,
-0.0036741483490914106,
-0.00476033054292202,
-0.018330935388803482,
0.008072113618254662,
-0.014525756239891052,
0.016406724229454994,
-0.015802321955561638,
0.015135672874748707,
0.013524522073566914,
0.008230721578001976,
-0.00265943119302392,
-0.008465657941997051,
-0.006042574532330036,
0.0003380030393600464,
0.011161765083670616,
0.010563588701188564,
-0.0012906738556921482,
-0.011477422900497913,
-0.0027896424289792776,
0.018079690635204315,
-0.015919730067253113,
0.03727961331605911,
0.01770789921283722,
0.005086109973490238,
-0.014507674612104893,
0.024758920073509216,
0.03757081180810928,
0.013964981772005558,
-0.018294770270586014,
0.005563319660723209,
-0.0240817591547966,
-0.014890540391206741,
-0.003906218335032463,
-0.020593222230672836,
-0.005918371491134167,
0.005388263612985611,
-0.010480411350727081,
-0.019015757367014885,
0.02591446042060852,
0.02017613872885704,
-0.031198494136333466,
-0.01631915755569935,
-0.007603154517710209,
-0.0049077835865318775,
-0.00022085534874349833,
-0.0007627438753843307,
0.018264755606651306,
-0.0038482779636979103,
-0.00019030552357435226,
-0.029642567038536072,
-0.006075688637793064,
0.006319413892924786,
0.0067507605999708176,
0.011878724209964275,
-0.0008461670950055122,
-0.015312484465539455,
-0.014474758878350258,
0.003288678824901581,
-0.0015767912846058607,
-0.011031745001673698,
0.010176231153309345
] | [
-0.17926844954490662,
0.28399351239204407,
-0.3445329964160919,
-0.3327580392360687,
-0.24411872029304504,
0.3890501856803894,
0.633490800857544,
0.35643747448921204,
-0.155351459980011,
-0.7199073433876038,
-0.18009430170059204,
0.20539748668670654,
-0.5176666378974915,
0.31999528408050537,
-0.1407473236322403,
0.8004797101020813,
0.20326901972293854,
0.6560491323471069,
-0.5698471069335938,
-0.0299194548279047,
-0.3475014269351959,
-0.5647336840629578,
0.5516887903213501,
0.04436453804373741,
0.20685529708862305,
-0.26668551564216614,
0.5382174253463745,
0.4647218585014343,
-0.03968587890267372,
-0.2525027096271515,
0.16184455156326294,
0.7326720952987671,
0.17709492146968842,
-0.4296129047870636,
-0.38023141026496887,
-0.04690519720315933,
-0.5284425616264343,
-0.4376561641693115,
0.29547953605651855,
0.06740672141313553,
-0.1873978227376938,
-0.09916070103645325,
0.13119007647037506,
0.6665993928909302,
-0.022477304562926292,
0.20709462463855743,
-1.2449498176574707,
0.9136489629745483,
0.19796554744243622,
0.2622588872909546,
0.2520366311073303,
0.41427838802337646,
0.04401630908250809,
0.07490066438913345,
-0.13947530090808868,
0.42808976769447327,
-0.8509503602981567,
-0.01976895146071911,
0.2852769196033478,
-0.6005253195762634,
-0.016723662614822388,
0.38060706853866577,
-0.2953488826751709,
-0.04112755134701729,
-0.277386337518692,
0.63612961769104,
-0.10125512629747391,
0.09123505651950836,
-0.7583354115486145,
-0.22759385406970978,
-0.09025105088949203,
-0.29740551114082336,
-0.3307938873767853,
0.2894480526447296,
0.04361242428421974,
-0.4440371096134186,
-0.49181926250457764,
-0.4233875274658203,
-0.01671580597758293,
0.14616523683071136,
0.12664800882339478,
0.08370149880647659,
0.23449823260307312,
0.0025881354231387377,
0.37210583686828613,
0.058699581772089005,
0.2525395154953003,
0.7677898406982422,
-0.39264750480651855,
-0.31767165660858154,
0.25863778591156006,
0.2743730843067169,
0.766934871673584,
-0.10172691196203232,
-0.035560183227062225,
0.32626786828041077,
0.15201988816261292,
0.07745363563299179,
0.12354224175214767,
0.040775347501039505,
-0.43006739020347595,
-0.2295609414577484,
-0.03688320145010948,
-0.013052686117589474,
-0.16356642544269562,
0.04101214557886124,
-0.2821674048900604,
-0.3668135106563568,
-0.10716190189123154,
0.05597533658146858,
-0.4795946478843689,
0.032962020486593246,
-0.07707183808088303,
-0.3938664495944977,
-0.27210989594459534,
-0.1724683791399002,
-0.1513899713754654,
-0.5607655644416809,
-0.14456352591514587,
-0.2730545103549957,
0.025847921147942543,
0.634967029094696,
-0.2608596086502075,
0.4760216772556305,
-0.29315185546875,
-0.25751495361328125,
0.09897302091121674,
-0.23491095006465912,
-0.2316255122423172,
0.2916361093521118,
0.6266236901283264,
0.8607334494590759,
-0.4630129635334015,
0.26620161533355713,
-0.023239783942699432,
0.05868753790855408,
-0.13001836836338043,
0.1859760731458664,
0.50641268491745,
-0.1657368689775467,
-0.846000611782074,
-0.5441240072250366,
-0.23787090182304382,
0.11811098456382751,
-0.18637895584106445,
-0.49600496888160706,
-0.2789324223995209,
0.24190080165863037,
-0.14793403446674347,
-0.5919709205627441,
0.20455698668956757,
-0.3790631890296936,
-0.9252002239227295,
0.06687945872545242,
0.06821327656507492,
0.10330911725759506,
-0.019556526094675064,
-0.7374948263168335,
-0.030764909461140633,
-0.0022185167763382196,
-0.03623226657509804,
0.07438256591558456,
-0.6179459095001221,
-0.07079191505908966,
0.2734827399253845,
0.032716814428567886,
-0.07497460395097733,
0.7179771661758423,
-0.2016669362783432,
0.06063707545399666,
-0.2635638415813446,
0.1343853771686554,
0.5216036438941956,
-0.49008888006210327,
0.25278210639953613,
0.17883974313735962,
0.05058511346578598,
-0.008836682885885239,
0.40802571177482605,
0.07631442695856094,
-0.6986287236213684,
0.23237325251102448,
-0.1188628077507019,
-0.04822210222482681,
0.08950075507164001,
0.15472419559955597,
0.22384761273860931,
-0.24661046266555786,
0.12382063269615173,
-0.024662405252456665,
-0.6239898204803467,
-0.3444027900695801,
0.5852370262145996,
-0.1335042268037796,
1.376633644104004,
-0.20057570934295654,
-0.7887702584266663,
0.9616909623146057,
0.41200920939445496,
0.08657104521989822,
-0.5278335213661194,
0.048418402671813965,
0.6559700965881348,
-0.2827880084514618,
-0.489095538854599,
0.11191499978303909,
-0.00021492499217856675,
-0.2285720556974411,
0.2204483598470688,
0.08825716376304626,
0.22977109253406525,
-0.6795005798339844,
-0.06485441327095032,
-0.2778405249118805,
0.21242396533489227,
-0.16748787462711334,
-0.4785889685153961,
-0.17448632419109344,
-0.23982340097427368,
-0.12348322570323944,
0.5174291729927063,
-0.5686190128326416,
0.18766622245311737,
0.5427823066711426,
-0.436417818069458,
0.4172912538051605,
0.3602665960788727,
-0.036586105823516846,
1.0225653648376465,
-0.2924593389034271,
0.5776230096817017,
-0.14018256962299347,
0.36499592661857605,
-0.4964711666107178,
-0.731318473815918,
0.17241832613945007,
0.29410824179649353,
-0.1556614339351654,
-0.039621807634830475,
-0.1822182834148407,
-0.21003806591033936,
0.8487383723258972,
-0.5262132287025452,
0.16695767641067505,
-0.1623590588569641,
-0.48497313261032104,
-0.3575879633426666,
0.6050485372543335,
-0.7080866694450378,
-0.022506186738610268,
0.31821778416633606,
0.5079318284988403,
-0.014061303809285164,
-0.3231641948223114,
0.26685407757759094,
0.0002887063892558217,
0.1273789256811142,
-0.10930709540843964,
0.10405886918306351,
-0.12915322184562683,
-0.23085655272006989,
0.11841409653425217,
-0.030044307932257652,
0.351688951253891,
0.36564287543296814,
-0.2609688937664032,
-0.6803991198539734,
-0.34928765892982483,
0.8147274255752563,
0.6666640639305115,
0.7113081216812134,
-0.1693892478942871,
-0.7047622203826904,
0.17971517145633698,
0.006260767579078674,
-0.2059413343667984,
-0.09802690148353577,
0.5623852014541626,
-0.8687976598739624,
-0.2581459581851959,
-0.3499450981616974,
0.11706747859716415,
0.4343850910663605,
-0.4349198043346405,
-0.2935560643672943,
0.04695354774594307,
-0.07402611523866653,
-0.5749749541282654,
-0.5270549654960632,
-0.33124589920043945,
-0.3233911097049713,
0.5520912408828735,
0.10459765791893005,
0.20639856159687042,
-0.09867747128009796,
0.052899956703186035,
0.03299103304743767,
0.27373647689819336,
0.9707655310630798,
-0.2426326870918274,
-0.08979377895593643,
-0.0513923242688179,
-0.36495503783226013,
0.03163617104291916,
-0.18303282558918,
0.2108655422925949,
-0.33791714906692505,
0.24498894810676575,
-5.963051795959473,
-0.24093657732009888,
-0.03779570385813713,
0.12627875804901123,
0.43965357542037964,
-0.15389995276927948,
0.9662690162658691,
-0.15345914661884308,
0.26728641986846924,
0.35109707713127136,
0.7711124420166016,
0.6672348976135254,
0.14705485105514526,
-0.2385898381471634,
-0.6304330825805664,
0.010585390962660313,
-0.05174590274691582,
-0.3792482912540436,
0.27713608741760254,
0.0021828091703355312,
0.45309749245643616,
-0.02953789196908474,
-0.3865034580230713,
0.49725791811943054,
0.024473877623677254,
0.3116660714149475,
-0.5223099589347839,
0.3670189678668976,
-0.40062233805656433,
0.02834944613277912,
-0.1672072410583496,
-0.8396574854850769,
0.08576393127441406,
-0.23176908493041992,
0.36868366599082947,
-0.30170193314552307,
-0.20372624695301056,
-0.2177330106496811,
-0.21141798794269562,
0.13312876224517822,
-0.023101605474948883,
-0.12552794814109802,
0.06033296510577202,
-0.2601962387561798,
0.4867517650127411,
-0.08843295276165009,
0.11279555410146713,
-0.32765936851501465,
0.08899559825658798,
0.921389639377594,
0.29810965061187744,
-0.22765646874904633,
0.5854352116584778,
0.8584745526313782,
0.8173251748085022,
0.17267128825187683,
0.20213831961154938,
0.028329355642199516,
0.20538799464702606,
-0.012127292342483997,
-0.1354323774576187,
0.07952739298343658,
-0.5753629803657532,
-0.17559202015399933,
-0.022329170256853104,
0.19373083114624023,
-0.26608598232269287,
-0.47585421800613403,
0.3833900988101959,
-0.41320326924324036,
0.006934529636055231,
-0.004781490191817284,
0.36580461263656616,
-0.8934897780418396,
0.600075900554657,
-0.34725409746170044,
-0.3391720950603485,
-0.1916549801826477,
0.040678080171346664,
-0.29371821880340576,
-0.7521154284477234,
-0.29614439606666565,
-0.4100115895271301,
-0.49679678678512573,
0.14338380098342896,
-0.3269501030445099,
0.15082713961601257,
-0.2106926590204239,
-0.10079672932624817,
-0.020855778828263283,
0.7029743194580078,
-0.8238349556922913,
0.24615706503391266,
0.09310303628444672,
0.4910140633583069,
1.0402082204818726,
0.26652848720550537,
0.8483957052230835,
0.592098593711853,
0.4828295409679413,
0.565665602684021,
-0.45799922943115234,
0.1388569474220276,
-0.22175908088684082,
0.06391631811857224,
0.12756790220737457,
0.015712985768914223,
0.3675955533981323,
0.8340148329734802,
-0.6678279042243958,
0.2479477822780609,
0.10002963989973068,
-0.5556370615959167,
-0.2923067808151245,
0.4522283971309662,
0.05125841125845909,
0.32908573746681213,
0.33684396743774414,
0.5947678089141846,
0.02983863651752472,
0.39556872844696045,
0.3097105920314789,
-0.9320196509361267,
0.5013872981071472,
-0.036249201744794846,
0.1683039516210556,
0.2129933387041092,
0.2070315182209015,
-0.2789510488510132,
-0.43962743878364563,
-0.01638646237552166,
0.10457464307546616,
-0.09912917762994766,
0.38269296288490295,
0.555993914604187,
-0.056695714592933655,
-0.19389300048351288,
-0.05740458518266678,
-0.20777566730976105,
-0.5662036538124084,
-0.35626041889190674,
0.011923376470804214,
-0.46726539731025696,
-0.20994028449058533,
-0.07216549664735794,
0.38990822434425354,
-0.28114163875579834,
-0.24010542035102844,
-0.10506542026996613,
0.0008454379858449101,
0.3232085406780243,
0.06456448137760162,
-0.13444344699382782,
0.3187468349933624,
-0.5485789179801941,
0.29021361470222473,
0.19129925966262817,
0.5086956024169922,
0.14451345801353455,
-0.667664110660553,
0.2043098509311676,
-0.2329784482717514,
-1.0079611539840698,
-0.1549149602651596,
-0.08649784326553345,
-0.40388956665992737,
0.4224836230278015,
-1.0170927047729492,
-0.04320146143436432,
0.43860846757888794,
-0.5369008183479309,
0.3245418071746826,
-0.12786057591438293,
-0.07961991429328918,
0.17143230140209198,
-0.403661847114563,
-0.4171047806739807,
0.05227602645754814,
-0.03502485528588295,
0.3220512270927429,
-0.05874781310558319,
0.2114279866218567,
-0.25473716855049133,
0.28973039984703064,
0.24015432596206665,
0.06971051543951035,
0.1254402995109558,
0.06293343752622604,
0.13125808537006378,
-0.46584245562553406,
0.22475692629814148,
0.0014173232484608889,
0.22282199561595917,
-0.32166019082069397,
-0.17079517245292664,
0.30593013763427734,
0.08283433318138123,
0.6235912442207336,
0.11344970017671585,
0.08224619179964066,
0.03832515329122543,
0.6056622862815857,
-0.4088679552078247,
0.11908872425556183,
0.415571004152298,
0.09578157216310501,
-0.053511690348386765,
-0.2462957501411438,
-0.1646016538143158,
-0.6065786480903625,
-0.11804338544607162,
-0.36515551805496216,
-0.02574114128947258,
0.5789300203323364,
-0.2692001163959503,
-0.15326231718063354,
0.0824706181883812,
-0.4178943336009979,
0.04685423895716667,
0.3858371078968048,
-0.34088215231895447,
0.13472309708595276,
0.166518434882164,
-0.0004146953870076686,
-0.18542832136154175,
0.1264786422252655,
0.2722764313220978,
-0.7241882681846619,
0.29358407855033875,
0.035941217094659805,
0.5986946821212769,
0.01786368526518345,
0.39841997623443604,
0.12396537512540817,
-0.19756852090358734,
-0.20378439128398895,
0.22788643836975098,
0.008194140158593655,
-0.3301968276500702,
0.396226167678833,
0.37986427545547485,
-0.01638919860124588,
-0.20510250329971313,
-0.09828754514455795,
0.1375012844800949,
0.27612724900245667,
0.31434300541877747,
-0.3980208933353424,
-0.390622615814209,
0.12277062237262726,
0.5994670391082764,
0.10031543672084808,
-0.1378730833530426,
0.6082969307899475,
0.47203508019447327,
-0.31146860122680664,
0.2106834501028061,
-0.37523263692855835,
-0.03155314549803734,
0.23793122172355652,
-0.19390392303466797,
0.38655707240104675,
0.37440982460975647,
0.2537918984889984,
-0.20753152668476105,
-0.23000285029411316,
-0.266432523727417,
-0.7133915424346924,
0.2919211983680725,
0.31926730275154114,
0.11489973962306976,
0.2957647144794464,
0.8726069927215576,
0.3488752543926239,
-0.14290039241313934,
0.3774887025356293,
-0.5562060475349426,
-0.13488970696926117,
-0.2667669653892517,
0.5148191452026367,
-0.3743733763694763,
-0.6817458868026733,
-0.2898009121417999,
-0.23407940566539764,
0.19343873858451843,
-0.3118119239807129,
0.19876135885715485,
-0.4114222824573517,
-0.3203538954257965,
-0.3214004933834076,
-0.580998420715332,
0.09125778824090958,
-0.348465234041214,
-0.31447285413742065,
0.04165927693247795,
-0.1782880574464798,
-0.1532617062330246,
0.26711219549179077,
-0.38867253065109253,
0.054835524410009384,
-0.8344947695732117,
0.4724515378475189,
0.5696332454681396,
-0.23158295452594757,
0.07815885543823242,
0.11403137445449829,
0.06601379811763763,
-0.04849781468510628,
-0.39226940274238586,
-0.05580442398786545,
0.26749294996261597,
-0.33977973461151123,
0.2471386343240738,
0.13043412566184998,
0.08094281703233719,
0.678324282169342,
0.05003388226032257,
-0.3333938419818878,
-0.08059608936309814,
0.478621244430542,
0.44197091460227966,
0.35898375511169434,
0.06119070202112198,
-0.14206980168819427,
0.1477084755897522,
0.5580691695213318,
0.05648849532008171,
0.17577515542507172,
0.3000554144382477,
0.8156038522720337,
0.3468843102455139,
-0.008592497557401657,
-0.6490289568901062,
0.24100132286548615,
0.41403597593307495,
-0.13329224288463593,
0.2988050580024719,
-0.6125678420066833,
-0.33127909898757935,
0.023287510499358177,
0.7682198286056519,
0.14514513313770294,
-0.41550353169441223,
-0.3659958839416504,
0.3211565911769867,
0.5093019604682922,
-0.28190910816192627,
-0.18915186822414398,
-0.2462245523929596,
0.1368420273065567,
0.37125715613365173,
-0.5993813872337341,
-0.48799458146095276,
0.2735182046890259,
-0.22168631851673126,
0.38137537240982056,
0.48714393377304077,
-0.6496055722236633,
-0.7636693120002747,
0.1752546727657318,
0.06968218088150024,
0.20231667160987854,
-0.055756255984306335,
0.1298639327287674,
0.0016751098446547985,
0.0042311688885092735,
0.21294648945331573,
-0.24592190980911255,
-0.12326636165380478,
-0.10358013957738876,
-0.1485857218503952,
-0.33640268445014954,
-0.34639739990234375,
0.23079420626163483,
0.7377533912658691,
-0.2805243730545044,
0.3557923436164856,
0.4518453776836395,
0.08406823128461838,
0.5277194976806641,
-0.771053671836853,
0.0660625770688057,
-0.21732887625694275,
-0.4932086169719696,
-0.190491184592247,
0.07446131110191345,
-0.08901078999042511,
-0.3540581464767456,
0.10242760926485062,
-0.12846603989601135,
-0.036960043013095856,
-0.21305882930755615,
-0.4565829336643219,
0.5285547375679016,
0.019779453054070473,
-0.4166645407676697,
0.2507425546646118,
0.39852067828178406,
0.10900210589170456,
0.4519656002521515,
0.31428053975105286,
0.015126054175198078,
-0.218992218375206,
0.15051671862602234,
-0.9018935561180115,
0.28180599212646484,
-0.41933783888816833,
0.017768513411283493,
-0.5860191583633423,
-0.15400554239749908,
0.7157148718833923,
0.6131238341331482,
-0.128057599067688,
0.03149239346385002,
-0.07272457331418991,
0.07986278831958771,
0.3180130422115326,
-0.6787952184677124,
-0.11354343593120575,
-0.3312879800796509,
0.44765329360961914,
-0.3930692970752716,
0.7150657176971436,
0.08990901708602905,
-0.32801660895347595,
-0.055449798703193665,
0.40355047583580017,
0.13071706891059875,
-0.55195152759552,
0.23682357370853424,
-0.4321357309818268,
0.4545947313308716,
-0.3134746253490448,
0.42280203104019165,
-0.26040157675743103,
-0.03474930301308632,
0.22832156717777252,
-0.2636815905570984,
0.29871323704719543,
-0.23889155685901642,
0.5002930760383606,
-0.3651248812675476,
0.05460342764854431,
-0.1492144912481308,
0.09435445070266724,
0.17368392646312714,
-0.08407240360975266,
-0.3086211681365967,
-0.17849916219711304,
0.2168169766664505,
0.06832154840230942,
-0.4241217076778412,
-0.21320225298404694,
0.37769246101379395,
-0.0197847131639719,
-0.6478772163391113,
-0.09002961218357086,
-0.10222584009170532,
0.03661361709237099,
-0.10532782226800919
] |
This article is one of ten reviews selected from the Yearbook of Intensive Care and Emergency Medicine 2010 (Springer Verlag) and co-published as a series in Critical Care. Other articles in the series can be found online at http://ccforum.com/series/yearbook. Further information about the Yearbook of Intensive Care and Emergency Medicine is available from http://www.springer.com/series/2855. | [
-0.007347647100687027,
0.0006036144914105535,
-0.004885809496045113,
0.028483016416430473,
-0.018169820308685303,
0.021487213671207428,
0.011042098514735699,
0.011195546947419643,
-0.01837104558944702,
-0.0016916620079427958,
-0.004501131363213062,
0.022034596651792526,
0.017974775284528732,
-0.0005218334845267236,
0.0021881351713091135,
0.0028061610646545887,
-0.017861565575003624,
0.03823552280664444,
0.015054953284561634,
0.0044144196435809135,
-0.010905307717621326,
-0.011774704791605473,
0.008969482034444809,
-0.022972330451011658,
-0.010284679010510445,
0.015288087539374828,
0.03913922607898712,
-0.01834684982895851,
0.013287554495036602,
-0.001817010692320764,
0.01497957669198513,
0.029998812824487686,
0.01750374771654606,
0.030784213915467262,
0.015272567979991436,
-0.016628697514533997,
-0.014299515634775162,
-0.003979135304689407,
-0.07372219115495682,
-0.004124233964830637,
-0.008894816972315311,
-0.0023147445172071457,
0.012143503874540329,
0.0020484935957938433,
-0.008274090476334095,
0.0113700395449996,
-0.013138201087713242,
0.014133637771010399,
0.004806985147297382,
0.007818329147994518,
-0.01132558099925518,
0.005378312896937132,
-0.0024898587726056576,
-0.01526578702032566,
-0.006510803941637278,
-0.004242876078933477,
0.022114723920822144,
-0.0038136765360832214,
-0.011785858310759068,
0.0317065492272377,
0.0008961662533693016,
0.006423153914511204,
0.006365892011672258,
0.025595994666218758,
0.0016105580143630505,
-0.06650721281766891,
0.021612830460071564,
0.017522064968943596,
0.009169901721179485,
0.00515073724091053,
-0.01478020939975977,
0.016537072136998177,
-0.012636702507734299,
0.01721903681755066,
0.0246055219322443,
-0.008137473836541176,
-0.008070718497037888,
0.028098950162529945,
-0.00994270108640194,
-0.01919926330447197,
0.007611083798110485,
-0.010244220495223999,
-0.015132943168282509,
0.03898623213171959,
0.0056385318748652935,
0.0015800042310729623,
-0.0005041233380325139,
0.004828629549592733,
0.006534424144774675,
0.020897027105093002,
0.007486299145966768,
0.006567389238625765,
-0.00808768067508936,
-0.01643330790102482,
-0.0038390601985156536,
0.008587309159338474,
-0.021293645724654198,
-0.007327043917030096,
-0.00451890891417861,
-0.007118189241737127,
-0.011071289889514446,
0.022297007963061333,
0.02433125674724579,
0.0032876208424568176,
-0.015287905931472778,
0.004806067328900099,
0.009604927152395248,
0.013562601059675217,
-0.005614160094410181,
0.003903261385858059,
-0.0042296890169382095,
-0.020670846104621887,
-0.008175515569746494,
-0.0024112509563565254,
-0.01895781420171261,
-0.01152288168668747,
0.006734959781169891,
0.020205702632665634,
0.006769990082830191,
-0.02082744985818863,
0.019137443974614143,
-0.03830400109291077,
-0.0024065503384917974,
-0.006498175673186779,
0.003181654494255781,
0.03979930281639099,
-0.018374919891357422,
-0.038072619587183,
-0.014399058185517788,
-0.004231455270200968,
-0.008548487909138203,
-0.016350382938981056,
0.029024099931120872,
0.051052309572696686,
-0.0027102595195174217,
-0.0173490010201931,
-0.030868778005242348,
-0.008364757522940636,
-0.002759229391813278,
0.007638432085514069,
-0.004167682956904173,
0.006525931879878044,
-0.0006608592811971903,
0.01386117935180664,
-0.006374859716743231,
-0.00006866839248687029,
0.009936807677149773,
0.00171059335116297,
-0.008858607150614262,
-0.01005718857049942,
-0.0018832199275493622,
-0.013973070308566093,
-0.0161624476313591,
-0.0056655085645616055,
0.004714298993349075,
-0.0014254591660574079,
-0.0005730519769713283,
-0.005537603981792927,
-0.00031625706469640136,
0.0034404457546770573,
0.00742502324283123,
0.019873104989528656,
0.008734273724257946,
0.008846641518175602,
-0.02036738581955433,
0.045546483248472214,
-0.030431976541876793,
-0.0038379670586436987,
0.007265978027135134,
0.0003274116024840623,
-0.0025297473184764385,
-0.0017413882305845618,
-0.008339340798556805,
0.006834808271378279,
-0.001075156731531024,
-0.008193143643438816,
0.002278745174407959,
0.005258583929389715,
-0.019904782995581627,
0.06694958359003067,
0.007759832311421633,
0.00009875813702819869,
0.020510299131274223,
0.015718746930360794,
0.005295056849718094,
-0.012713884934782982,
0.05312485620379448,
-0.002508931327611208,
-0.012589169666171074,
0.022361725568771362,
0.016506824642419815,
-0.018680185079574585,
-0.011103562079370022,
-0.0020566238090395927,
-0.016015635803341866,
0.0024707645643502474,
0.04055662825703621,
0.0018176035955548286,
-0.002306528389453888,
0.014886264689266682,
-0.009198714978992939,
0.014981001615524292,
0.040795374661684036,
0.00828300416469574,
0.01705419458448887,
0.017535606399178505,
-0.0009495714330114424,
-0.0065739038400352,
0.01787940040230751,
0.0161025058478117,
-0.00046460560406558216,
-0.011392930522561073,
0.01359076239168644,
-0.009749075397849083,
-0.034579794853925705,
0.004732721019536257,
0.007126465439796448,
-0.004258275963366032,
0.0030973537359386683,
-0.019540799781680107,
-0.017064161598682404,
-0.002809882164001465,
-0.039580993354320526,
-0.030998917296528816,
0.02962922863662243,
0.031103655695915222,
0.03669150918722153,
0.015173726715147495,
-0.008144666440784931,
0.000616677338257432,
-0.025869153439998627,
-0.012229179963469505,
-0.01101523358374834,
0.018935495987534523,
-0.0013326382031664252,
-0.025622008368372917,
0.015073630027472973,
-0.006848401855677366,
0.007302701938897371,
-0.013063319027423859,
0.0005227572983130813,
0.015122193843126297,
-0.004190581385046244,
0.03412654623389244,
0.022748654708266258,
0.003137839725241065,
-0.005346252582967281,
-0.009389559738337994,
0.02563636563718319,
0.011990806087851524,
0.001390953315421939,
-0.014615539461374283,
-0.02387889102101326,
0.0030824372079223394,
0.007856380194425583,
-0.016499536111950874,
-0.004871021490544081,
0.031588099896907806,
0.02548810839653015,
0.015102186240255833,
0.007835710421204567,
0.0031277970410883427,
-0.018928829580545425,
-0.019192436710000038,
0.006045718677341938,
0.0234114658087492,
0.018354713916778564,
0.022357532754540443,
0.03359090909361839,
0.014788100495934486,
0.0020451529417186975,
-0.01097231823951006,
-0.005160714033991098,
-0.08148500323295593,
-0.008375672623515129,
0.0005434404592961073,
-0.02460077404975891,
0.012456836178898811,
-0.010852404870092869,
0.0067999050952494144,
0.005681933835148811,
-0.015020373277366161,
0.04622790217399597,
-0.02783859334886074,
0.02925504371523857,
-0.015317870303988457,
0.0016816873103380203,
0.017008766531944275,
-0.009599164128303528,
0.01593621075153351,
0.02358088456094265,
-0.035377852618694305,
0.027915501967072487,
0.01793489046394825,
-0.028317280113697052,
0.03308343514800072,
0.013212410733103752,
0.030863113701343536,
0.021743426099419594,
0.04009683057665825,
0.0010468557011336088,
-0.022686714306473732,
0.020713089033961296,
0.010321984998881817,
-0.0012818912509828806,
-0.02210191823542118,
0.02072855457663536,
-0.005359536502510309,
0.02049105241894722,
0.013609462417662144,
-0.0040290383622050285,
-0.005002587102353573,
0.007790856529027224,
0.004146950785070658,
0.01873921789228916,
-0.018778014928102493,
-0.033616453409194946,
-0.013743538409471512,
0.00851436797529459,
0.0014801034703850746,
-0.00364134949631989,
0.01280470471829176,
-0.00582424271851778,
0.01625063084065914,
-0.013671113178133965,
0.005438539199531078,
0.013394766487181187,
-0.010960813611745834,
0.01029081828892231,
-0.009215333499014378,
0.01935080625116825,
-0.0008138862322084606,
-0.0016925892559811473,
-0.021693769842386246,
0.02594565413892269,
0.005574207287281752,
0.014299722388386726,
-0.0009413373772986233,
0.03049728460609913,
-0.0028036152943968773,
0.007755423430353403,
-0.020535118877887726,
-0.013212577439844608,
0.03240956738591194,
0.007980930618941784,
0.0157321784645319,
-0.010237524285912514,
-0.00983087345957756,
-0.01232138741761446,
-0.02568204700946808,
-0.012262798845767975,
-0.005808508954942226,
0.0032606772147119045,
0.0015995465219020844,
0.005718284752219915,
0.02098885178565979,
0.011711194179952145,
-0.013685938902199268,
-0.05222603678703308,
0.021696673706173897,
0.020688463002443314,
0.010929993353784084,
-0.009209176525473595,
0.024169189855456352,
0.017489107325673103,
-0.006503758952021599,
0.009949336759746075,
0.003954034298658371,
-0.019953519105911255,
0.02478640340268612,
0.006310789845883846,
0.02994181029498577,
0.010794054716825485,
-0.009149142540991306,
-0.01639385335147381,
0.003745440626516938,
-0.009254668839275837,
-0.003409413853660226,
0.005557511933147907,
-0.03300771489739418,
0.009803184308111668,
-0.010411984287202358,
-0.011168956756591797,
-0.00021932665549684316,
0.017405277118086815,
-0.007633809465914965,
0.03065468557178974,
0.006610296666622162,
-0.010583262890577316,
-0.00910970102995634,
-0.012833086773753166,
0.07151289284229279,
-0.026230955496430397,
0.01857314072549343,
0.011071370914578438,
-0.009032958187162876,
-0.02185913175344467,
0.014835087582468987,
-0.0011555731762200594,
0.03317601978778839,
0.00034944681101478636,
0.013273030519485474,
0.012263537384569645,
0.009715770371258259,
0.022454172372817993,
0.009514229372143745,
-0.0010435577714815736,
-0.02824251353740692,
0.0015618805773556232,
-0.03723093867301941,
0.00005002273610443808,
-0.0011595942778512836,
0.0030992894899100065,
-0.021169587969779968,
-0.01897435076534748,
0.02091478370130062,
-0.0029232508968561888,
-0.0089045949280262,
-0.02107364311814308,
-0.004338518250733614,
0.0027179333847016096,
-0.0038659004494547844,
0.004710368812084198,
-0.015324539504945278,
-0.013745099306106567,
0.0348471999168396,
-0.015713362023234367,
-0.008114253170788288,
-0.013208700343966484,
-0.006042733788490295,
-0.010314442217350006,
-0.009493391029536724,
-0.006863378919661045,
-0.02340567484498024,
0.005790360271930695,
0.030712537467479706,
0.011733357794582844,
0.0023599681444466114,
-0.004976110998541117,
-0.02013220451772213,
0.004123431630432606,
-0.0023392566945403814,
0.013654787093400955,
0.011980187147855759,
-0.007715835236012936,
0.016814617440104485,
0.012187534011900425,
0.002255061874166131,
0.005098645109683275,
-0.01053294725716114,
0.01716483198106289,
-0.01649460382759571,
-0.03656283766031265,
-0.03180363401770592,
-0.011143481358885765,
0.010900077410042286,
0.000537122949026525,
0.024873288348317146,
-0.006571263540536165,
0.0076954178512096405,
0.006210346706211567,
-0.005887337028980255,
-0.006832932122051716,
-0.03376443684101105,
0.010712223127484322,
-0.0006059162551537156,
-0.016354434192180634,
0.009975772351026535,
-0.0364246591925621,
0.030796142295002937,
-0.003651169128715992,
-0.010829119011759758,
0.003638907102867961,
0.032903559505939484,
-0.00006370031042024493,
0.015061077661812305,
0.008892593905329704,
-0.02645672671496868,
-0.07342777401208878,
-0.0015403099823743105,
0.04353109747171402,
-0.006313258782029152,
-0.02616526000201702,
0.007433281280100346,
-0.015980444848537445,
0.020184407010674477,
-0.010053749196231365,
-0.0053818547166883945,
0.02573496475815773,
0.017498642206192017,
-0.021503988653421402,
-0.01299448125064373,
0.011593017727136612,
-0.0021314085461199284,
0.02458326332271099,
-0.013269279152154922,
-0.021402304992079735,
-0.009604684077203274,
-0.005000009201467037,
-0.005730546545237303,
0.009361178614199162,
-0.010682644322514534,
0.003581314580515027,
-0.0804215744137764,
-0.00266966107301414,
0.016420142725110054,
0.010670283809304237,
0.004416873678565025,
-0.021656934171915054,
-0.01370114367455244,
-0.034760814160108566,
-0.00919274054467678,
-0.011825996451079845,
-0.03648282214999199,
0.01375723909586668,
0.04770926758646965,
0.01251834537833929,
0.011930152773857117,
-0.008097448386251926,
0.024144921451807022,
-0.045144740492105484,
-0.011111941188573837,
0.019700944423675537,
-0.012691273353993893,
0.0349360853433609,
-0.003473457647487521,
0.002257302636280656,
-0.004419564735144377,
0.0016490297857671976,
-0.031016601249575615,
0.021702541038393974,
0.039731815457344055,
-0.02628786861896515,
-0.005359848961234093,
0.0015013482188805938,
-0.014846589416265488,
-0.004221880342811346,
0.02484394609928131,
0.0027987263165414333,
0.019995784386992455,
0.009245668537914753,
-0.011438689194619656,
-0.010389497503638268,
0.009947356767952442,
0.04277759790420532,
0.0016891697887331247,
-0.009698636829853058,
-0.000191503728274256,
-0.005042713601142168,
0.01079749595373869,
-0.010146855376660824,
-0.014099755324423313,
0.019352421164512634,
0.0012843621661886573,
0.014613009057939053,
0.0034024082124233246,
-0.017087681218981743,
-0.011450709775090218,
-0.011212303303182125,
-0.004105331841856241,
-0.01924203895032406,
0.00699259527027607,
0.004925485700368881,
0.0017602742882445455,
0.015239718370139599,
-0.009302075952291489,
0.07185947149991989,
0.008967473171651363,
0.008351050317287445,
-0.0020115836523473263,
-0.007583374157547951,
0.003652347018942237,
-0.010988309979438782,
-0.010644682683050632,
0.016463711857795715,
0.008308728225529194,
0.0209819208830595,
-0.008554971776902676,
-0.0023950424510985613,
-0.0015537857543677092,
0.0027174323331564665,
-0.01704038493335247,
0.0026460972148925066,
-0.0017821668880060315,
-0.022380126640200615,
-0.013867855072021484,
0.03288424760103226,
0.03502778336405754,
0.010113738477230072,
0.005228825379163027,
-0.005459409207105637,
-0.007232117932289839,
-0.009809802286326885,
0.0013304352760314941,
-0.0012325398856773973,
-0.004855552688241005,
-0.015187285840511322,
-0.008961752988398075,
0.001886410522274673,
0.015230468474328518,
0.02800910547375679,
-0.017060302197933197,
-0.020124098286032677,
0.009573136456310749,
-0.009757050313055515,
0.0070212967693805695,
0.01116891484707594,
-0.018375679850578308,
0.010483765043318272,
-0.0032595528755337,
0.024189412593841553,
0.02879250980913639,
-0.0020328997634351254,
0.003060158109292388,
-0.002394198440015316,
-0.0022557249758392572,
-0.019935166463255882,
0.013876826502382755,
-0.008979246951639652,
-0.009117841720581055,
-0.0289215836673975,
-0.0008101632120087743,
-0.03665924444794655,
0.02634243108332157,
0.010104314424097538,
-0.006438690237700939,
0.020837100222706795,
-0.008684084750711918,
0.023228084668517113,
-0.024863149970769882,
-0.006810772232711315,
-0.02539551444351673,
0.007472108118236065,
-0.011806144379079342,
-0.024075375869870186,
0.010336357168853283,
-0.016763372346758842,
-0.025716643780469894,
0.0025426179636269808,
0.030840279534459114,
-0.025099363178014755,
0.0021877873223274946,
0.015494212508201599,
0.018093761056661606,
0.02179100550711155,
0.001360266818664968,
-0.014650053344666958,
-0.03579701855778694,
-0.014960946515202522,
-0.010765155777335167,
-0.03105797804892063,
-0.009731192141771317,
-0.0008806088590063155,
-0.011129617691040039,
-0.0049733747728168964,
0.014688165858387947,
0.008502155542373657,
0.008459358476102352,
0.0063843014650046825,
0.0005775453755632043,
-0.001211789553053677,
0.03508633375167847,
0.012130694463849068,
-0.0014381924411281943,
0.00007857581658754498,
-0.022455889731645584,
0.01651136949658394,
-0.0093728331848979,
-0.003517287550494075,
0.0016658309614285827,
0.014120158739387989,
0.00002676770782272797,
0.023854445666074753,
0.02511722967028618,
-0.017031054943799973,
0.03139536827802658,
-0.011334806680679321,
-0.025366228073835373,
0.006656017620116472,
0.00003333988934173249,
-0.010325898416340351,
-0.012469264678657055,
-0.008350069634616375,
0.03551683574914932,
-0.01929335482418537,
-0.012208223342895508,
0.01068731676787138,
-0.012770093977451324,
-0.009425817988812923,
0.023899555206298828,
0.013179037719964981,
-0.027879489585757256,
-0.0010964043904095888,
-0.0063406191766262054,
-0.024256877601146698,
0.004954783711582422,
0.016181308776140213,
-0.004140213597565889,
0.0016005263896659017,
-0.02847771719098091,
0.007197764702141285,
-0.031738460063934326,
-0.002601858926936984,
-0.03005233220756054,
-0.01506101619452238,
0.008604604750871658,
0.004288851283490658,
0.010733191855251789,
0.0045854197815060616,
0.0027521417941898108,
0.010501670651137829,
-0.009502875618636608,
0.0018670144490897655,
0.006354509387165308,
0.0068744877353310585,
0.030113166198134422,
0.003154118312522769,
0.00911375880241394,
-0.012215464375913143,
-0.0008935312507674098,
-0.000015272615200956352,
0.019596213474869728,
0.0029239507857710123,
0.004660219419747591,
0.007757511455565691,
-0.01613646373152733,
-0.02359497733414173,
-0.030719241127371788,
-0.013430735096335411,
0.014138889499008656,
-0.005500153638422489,
-0.011638624593615532,
0.013642205856740475,
-0.020067978650331497,
-0.027870748192071915,
0.010873937979340553,
-0.01827201619744301,
-0.007175570819526911,
-0.01319484505802393,
0.03806089237332344,
0.013681369833648205,
-0.004713009111583233,
0.013924878090620041,
0.009247119538486004,
0.011936900205910206,
0.015345116145908833,
-0.011708208359777927,
-0.015039468184113503,
0.011811109259724617,
-0.020061049610376358,
0.00026405317476019263,
-0.00423892866820097,
-0.02837006002664566,
0.016259118914604187,
-0.00009860605496214703,
-0.006669859401881695,
-0.005847959779202938,
0.03838055953383446,
-0.019874239340424538,
-0.0011112104402855039,
-0.002305051311850548,
0.007049518171697855,
-0.023754356428980827,
-0.009786901995539665,
0.00279413303360343,
0.011221352033317089,
-0.007447679061442614,
-0.013109021820127964
] | [
0.15632688999176025,
0.08367343246936798,
-0.16722287237644196,
-0.1195012778043747,
-0.3415829837322235,
0.08967508375644684,
0.1676718294620514,
0.019686618819832802,
-0.2502860128879547,
-0.5424987077713013,
-0.06753616034984589,
0.28407996892929077,
0.2866021394729614,
0.4230915307998657,
-0.3999379277229309,
0.861114501953125,
0.4595797061920166,
0.2548728883266449,
-0.204738587141037,
-0.6008036136627197,
-0.1865529865026474,
-0.050366055220365524,
0.5715946555137634,
-0.0957367867231369,
-0.24748174846172333,
0.21269962191581726,
0.253314733505249,
0.3554432690143585,
-0.2972652316093445,
-0.34308233857154846,
-0.12216859310865402,
0.49736592173576355,
0.20293833315372467,
-0.032919470220804214,
0.20145727694034576,
0.16870684921741486,
-0.016611939296126366,
-0.27151161432266235,
0.1520877331495285,
-0.4376598596572876,
-0.033657051622867584,
0.106996551156044,
-0.4618605375289917,
0.7269021272659302,
0.37736445665359497,
-0.3716582953929901,
-1.4666309356689453,
0.015930062159895897,
-0.43884193897247314,
0.4150334894657135,
0.03240972384810448,
0.36850273609161377,
1.0140299797058105,
0.2805376648902893,
-0.3241647183895111,
0.27464401721954346,
-0.5559269189834595,
-0.2737260162830353,
0.03101685456931591,
-0.28443989157676697,
0.06080830097198486,
-0.15786412358283997,
0.569792628288269,
0.5212403535842896,
0.4299643933773041,
0.5592373609542847,
0.21439021825790405,
0.1819099485874176,
0.10963959991931915,
-0.2988249659538269,
-0.004309881944209337,
-0.7743905782699585,
0.12856420874595642,
0.05908684432506561,
0.023838018998503685,
-0.1444622427225113,
-0.17660778760910034,
-0.2678992748260498,
0.28965529799461365,
0.06261319667100906,
0.3798983097076416,
-0.13773442804813385,
0.45119455456733704,
-0.4265275299549103,
0.5196112990379333,
0.17608749866485596,
-0.307865172624588,
0.12400991469621658,
-0.6180378794670105,
0.05925220623612404,
-0.26360368728637695,
-0.11075256019830704,
0.47388985753059387,
0.5069125294685364,
0.6860906481742859,
0.2659160792827606,
0.3510574996471405,
0.29074952006340027,
-0.027803797274827957,
0.1606437712907791,
-0.10521972179412842,
0.41330257058143616,
0.2929874062538147,
-0.11192496865987778,
-0.8758442401885986,
-0.4641973376274109,
-0.12436311691999435,
-0.5528609156608582,
0.11846166104078293,
0.5453121066093445,
-0.46751415729522705,
0.57841557264328,
-0.1162160262465477,
-0.4476255774497986,
-0.3414416015148163,
0.5963810086250305,
0.16476693749427795,
-0.23665332794189453,
-0.34610670804977417,
0.8378586769104004,
-0.48759567737579346,
0.740675687789917,
0.3542722165584564,
0.04267462342977524,
0.025937985628843307,
0.5807573795318604,
0.6225932836532593,
0.3637731671333313,
-0.009128565900027752,
0.7284497022628784,
0.011043837293982506,
1.1047455072402954,
-0.3477213680744171,
0.019382517784833908,
0.058950286358594894,
-0.1892184168100357,
-0.040423762053251266,
0.30401527881622314,
-0.14724919199943542,
0.4508117437362671,
-0.2965727746486664,
-0.5554025173187256,
-0.418985515832901,
-0.4007875323295593,
-0.22907233238220215,
-0.5390027761459351,
-0.2872869372367859,
0.02725078910589218,
-0.4704076945781708,
-0.3551565110683441,
0.29459908604621887,
-0.2181834876537323,
-0.31657442450523376,
0.16713857650756836,
-0.010857069864869118,
0.8572140336036682,
0.2849256992340088,
-0.12944453954696655,
0.534122884273529,
-0.053584933280944824,
0.40239861607551575,
0.18543516099452972,
0.0682051032781601,
0.10046849399805069,
-0.14077073335647583,
-0.23334048688411713,
-0.061291687190532684,
-0.014552143402397633,
0.46389076113700867,
-0.19778096675872803,
-0.6624864339828491,
0.010199087671935558,
-0.36388373374938965,
-0.3299277424812317,
0.36000123620033264,
0.06214480847120285,
0.7242418527603149,
0.7682719826698303,
0.161298468708992,
-0.0029251007363200188,
-0.5870011448860168,
0.035936448723077774,
-0.37293460965156555,
-0.8743492364883423,
0.3695768117904663,
0.30758947134017944,
0.3217128813266754,
0.32359421253204346,
0.16722238063812256,
0.644131064414978,
-0.40480223298072815,
-0.18786302208900452,
0.1571573168039322,
-0.592250645160675,
1.349256992340088,
-0.32418093085289,
-0.18967679142951965,
0.8365520238876343,
-0.4319269061088562,
0.17381195724010468,
-0.012660767883062363,
0.1615956425666809,
0.26622214913368225,
0.2914251387119293,
-0.22841429710388184,
-0.20423969626426697,
-0.13769395649433136,
-0.1701900064945221,
-0.2367108166217804,
0.27987319231033325,
0.5286679863929749,
0.010010200552642345,
-0.4628934860229492,
0.03255867958068848,
-0.016448942944407463,
-0.06098375841975212,
0.2149687111377716,
0.5546295046806335,
-0.002335193334147334,
-0.08357540518045425,
1.5619312524795532,
-0.06506329774856567,
0.7363580465316772,
0.39174598455429077,
0.06439613550901413,
0.6129812598228455,
0.6279177665710449,
0.7630730867385864,
0.5560005307197571,
-0.6774057745933533,
0.31397804617881775,
0.15541282296180725,
0.3941003382205963,
-0.6865881085395813,
-0.22006161510944366,
0.16086509823799133,
-0.26692119240760803,
0.11360344290733337,
-0.18098491430282593,
-0.07010126113891602,
0.23916006088256836,
-0.15898621082305908,
-0.2948688268661499,
0.4621904194355011,
0.617029070854187,
-0.4071972072124481,
-0.271791011095047,
-0.03798150271177292,
-0.41230303049087524,
-0.2972249984741211,
0.5679786205291748,
0.5665819644927979,
0.2526104152202606,
-0.45714718103408813,
-0.08517331629991531,
0.29796817898750305,
-0.4335641860961914,
-0.5061963796615601,
0.1880231350660324,
0.3045782148838043,
-0.05412929505109787,
-0.030757596716284752,
0.06294850260019302,
0.1630697101354599,
-0.09824831038713455,
-0.3445909917354584,
-0.35280841588974,
-0.8744819164276123,
0.10920456796884537,
0.23756657540798187,
-0.19533561170101166,
0.27602341771125793,
-0.5366744995117188,
0.08249792456626892,
0.12740285694599152,
-0.7840492129325867,
-0.2456650286912918,
0.41181790828704834,
-0.6174765229225159,
-0.20534490048885345,
0.14125743508338928,
0.7558616399765015,
0.6159296631813049,
-0.05721256509423256,
-0.2660246193408966,
-0.3956073820590973,
0.04953232780098915,
-0.013911640271544456,
-0.24726496636867523,
-0.24727481603622437,
-0.24295668303966522,
0.10281109064817429,
-0.3117351830005646,
-0.5348011255264282,
0.4563629627227783,
0.42623841762542725,
0.03373374044895172,
0.3449346125125885,
0.09859167039394379,
-0.05169612541794777,
-0.04343625530600548,
0.5463319420814514,
-0.05682365596294403,
-0.07000119984149933,
0.029877588152885437,
-0.14163394272327423,
-0.6255994439125061,
0.3225993514060974,
-5.820389747619629,
-0.152179554104805,
-0.5226963758468628,
-0.0866611897945404,
-0.1320362091064453,
0.13237646222114563,
0.6762881278991699,
-0.28824949264526367,
-0.15511813759803772,
-0.23418086767196655,
0.25623801350593567,
0.29918786883354187,
0.5274595618247986,
0.6612387299537659,
0.18854445219039917,
0.5013329982757568,
0.25634366273880005,
0.32608380913734436,
0.15701332688331604,
0.009398585185408592,
-0.039046600461006165,
0.07990878820419312,
-0.2676428556442261,
0.4209156632423401,
0.576797366142273,
0.498062402009964,
-0.3559761643409729,
0.49450668692588806,
-0.319759726524353,
0.22247382998466492,
0.0877118855714798,
-0.25526079535484314,
-0.3969592750072479,
0.10040247440338135,
0.11294058710336685,
0.30504754185676575,
0.010516546666622162,
0.4440251886844635,
0.1333051174879074,
0.023241903632879257,
-0.11835228651762009,
0.4733852446079254,
-0.41180166602134705,
-0.5162448883056641,
0.15540631115436554,
-0.34449848532676697,
-0.2175314575433731,
0.2926161289215088,
-0.27847740054130554,
1.266546607017517,
0.03816624730825424,
-0.31622081995010376,
0.7630501985549927,
0.6631240844726562,
-0.3147723078727722,
-0.5083084106445312,
0.1332213282585144,
0.35695675015449524,
-0.1385136991739273,
0.10675254464149475,
0.05313199386000633,
-0.3782336115837097,
0.23111537098884583,
-1.0813438892364502,
-0.5958086252212524,
0.0507437139749527,
-0.7443553805351257,
-0.6775944828987122,
-0.0875261202454567,
-0.32368260622024536,
-0.49075695872306824,
0.037571243941783905,
0.13847064971923828,
-0.6921350955963135,
-0.06090506166219711,
-0.6582492589950562,
-0.34793025255203247,
0.14044484496116638,
-0.3681507706642151,
0.05013691261410713,
0.09229087084531784,
-0.2161792367696762,
-0.18615709245204926,
0.3038015365600586,
0.11877811700105667,
-0.7782580852508545,
-0.14096368849277496,
-0.18558254837989807,
-0.5165501236915588,
-0.06272202730178833,
0.6078683733940125,
-0.26138749718666077,
-0.06053006276488304,
0.7579631209373474,
-0.041603635996580124,
0.64945387840271,
0.8445408344268799,
-0.1947832703590393,
0.40427932143211365,
-0.6828519701957703,
0.5674863457679749,
-0.28628355264663696,
0.18519696593284607,
-0.6862499713897705,
-0.08636339753866196,
-0.15647722780704498,
-0.6899834871292114,
-0.03401685133576393,
0.5699234008789062,
-0.832101583480835,
0.08197685331106186,
-0.8578785061836243,
-0.21887564659118652,
-0.7099624872207642,
0.5275797247886658,
-0.3003700375556946,
-0.005953075829893351,
-0.04254830256104469,
0.2219225913286209,
0.06206405907869339,
-0.17987500131130219,
-0.42279332876205444,
-0.392744779586792,
0.12981493771076202,
0.3172667920589447,
0.1323346495628357,
0.024313338100910187,
0.3360553979873657,
-0.5176373720169067,
0.5937008261680603,
0.13600091636180878,
0.6543251872062683,
-0.1549462378025055,
0.40084362030029297,
0.09757021814584732,
-0.4279153645038605,
-0.5175688862800598,
0.07706071436405182,
0.21168558299541473,
-0.30814477801322937,
0.33400842547416687,
0.2072097510099411,
-0.6663174629211426,
-0.19705606997013092,
0.16160611808300018,
0.3605416417121887,
-0.010532556101679802,
-0.10586134344339371,
-0.14682550728321075,
0.6259793043136597,
-0.18415935337543488,
-0.24972516298294067,
-0.2277212291955948,
0.23996835947036743,
-0.27821084856987,
0.27513617277145386,
0.4517141878604889,
0.6916579604148865,
-0.36324241757392883,
-0.48021796345710754,
0.13810323178768158,
-0.2651512324810028,
-0.8330567479133606,
0.1207202821969986,
0.5163344740867615,
-0.13855721056461334,
-0.25690093636512756,
-0.4947679340839386,
-0.31127357482910156,
0.5967780351638794,
-0.03360562026500702,
0.1320066899061203,
-0.6439206600189209,
-0.3404019773006439,
0.2949554920196533,
0.09632918238639832,
0.11731573194265366,
0.39219900965690613,
0.17550720274448395,
-0.1231939047574997,
0.3386962413787842,
-0.9074007868766785,
0.1843232810497284,
0.31696927547454834,
0.5066512823104858,
0.45965903997421265,
-0.22459496557712555,
-0.5953114628791809,
-0.33229801058769226,
0.2077542096376419,
0.5120395421981812,
0.3381050229072571,
0.3835374712944031,
0.26297011971473694,
-0.3795790374279022,
-0.770899772644043,
0.1440892070531845,
-0.4323574900627136,
-0.19878317415714264,
-0.36271175742149353,
0.4104762375354767,
0.8887588381767273,
-0.5060886144638062,
0.7241360545158386,
-0.043226197361946106,
-0.6066689491271973,
0.32462581992149353,
0.25178661942481995,
-0.3852681517601013,
0.19816221296787262,
-0.3201564848423004,
-0.1942126303911209,
0.1016639694571495,
0.5805439352989197,
-0.4836466312408447,
0.4156308174133301,
0.4062291383743286,
-0.4660594165325165,
-0.5762108564376831,
0.20396974682807922,
0.06539708375930786,
0.07843249291181564,
-0.5960409641265869,
-0.3487814664840698,
-0.586688220500946,
0.134278804063797,
0.5576974749565125,
-0.4855334162712097,
0.018739767372608185,
-0.15484420955181122,
-0.32260027527809143,
0.021825550124049187,
0.15137550234794617,
-0.5956168174743652,
-0.11728166043758392,
-0.21271328628063202,
-0.535922646522522,
0.22781015932559967,
-0.043284352868795395,
-0.0679752454161644,
-0.3112330436706543,
0.12286163866519928,
-0.05856718495488167,
-0.6559905409812927,
-0.21529333293437958,
-0.41427743434906006,
0.38024699687957764,
-0.38620105385780334,
-0.7128241062164307,
-0.1506597399711609,
0.0889035165309906,
-0.45076435804367065,
-0.22565950453281403,
-0.8225731253623962,
0.7511177659034729,
0.0570349283516407,
-0.4655231833457947,
-0.0770970955491066,
-0.00041139760287478566,
0.31155967712402344,
-0.16904331743717194,
-0.10383079946041107,
-0.7069501876831055,
-0.18159161508083344,
0.43605127930641174,
0.3174354135990143,
0.1564694344997406,
-0.48882901668548584,
-0.11546143144369125,
-0.3118061423301697,
-0.10762592405080795,
0.15833225846290588,
0.06743548065423965,
0.18866890668869019,
0.35684165358543396,
0.4630781412124634,
-0.35073381662368774,
-0.48514631390571594,
-0.28755736351013184,
0.09726867824792862,
-0.2828518748283386,
-0.3010624051094055,
-0.11606833338737488,
0.10360457748174667,
0.2905348837375641,
-0.5318558812141418,
-0.323248952627182,
0.6020743250846863,
0.25467199087142944,
-0.1862868219614029,
-0.013409851118922234,
0.014887395314872265,
-0.9163677096366882,
0.033797670155763626,
0.36956706643104553,
0.5842777490615845,
0.30028730630874634,
0.38443368673324585,
0.2494945079088211,
-0.081380195915699,
-0.04094424471259117,
0.7247347831726074,
0.4191449284553528,
-0.00022465000802185386,
0.5453110337257385,
0.22725044190883636,
0.12235046923160553,
0.651421070098877,
-0.25212353467941284,
0.605116069316864,
0.6600338816642761,
-0.11570686846971512,
0.11636389791965485,
0.808781087398529,
-0.6319267153739929,
-0.22786784172058105,
-0.19541773200035095,
-0.6217157244682312,
0.3793482184410095,
-0.23867712914943695,
0.31279152631759644,
0.26236653327941895,
0.6995912790298462,
0.17487452924251556,
-1.1523526906967163,
0.3388725221157074,
-0.3482920527458191,
0.3852742910385132,
0.17588631808757782,
-0.35751596093177795,
0.6774189472198486,
0.7626274228096008,
-0.1480451226234436,
-0.01931406557559967,
-0.0979950875043869,
0.2352026253938675,
0.23625651001930237,
-0.6084033846855164,
-0.27813541889190674,
0.19214770197868347,
-0.05435815081000328,
0.4486820101737976,
0.24257470667362213,
0.18904602527618408,
-0.16166317462921143,
0.3042167127132416,
-0.7086513042449951,
-0.4075705409049988,
0.1938868910074234,
-0.4784925878047943,
-0.3106509745121002,
0.6817609071731567,
-0.07926272600889206,
-0.18494229018688202,
-0.2852398157119751,
0.032741960138082504,
0.022936614230275154,
-0.5424237251281738,
-0.2782348692417145,
0.3432677984237671,
0.2573705315589905,
0.184674933552742,
-0.6512870192527771,
0.4120326638221741,
-0.137124702334404,
0.038436464965343475,
0.5547850728034973,
-0.18386581540107727,
-0.005093475338071585,
-0.06831946969032288,
-0.45933210849761963,
-0.16376645863056183,
-0.2277490794658661,
0.15166179835796356,
-0.02127315290272236,
-0.36741337180137634,
0.46423691511154175,
-0.2863709628582001,
-0.16974104940891266,
0.6000490188598633,
-0.327153742313385,
0.37574848532676697,
-0.8161567449569702,
-0.318205863237381,
0.06001240387558937,
-0.1770893931388855,
-0.14050936698913574,
0.46709224581718445,
0.5123075842857361,
-0.35592398047447205,
0.23872631788253784,
-0.714904248714447,
-0.16728608310222626,
0.15094812214374542,
-0.48937639594078064,
-0.20695310831069946,
-0.31913885474205017,
0.6958420872688293,
0.6846483945846558,
-0.13562186062335968,
-0.4562378227710724,
-0.33920803666114807,
-0.1716803014278412,
0.2859218418598175,
-0.380746066570282,
0.22967025637626648,
-0.4771140515804291,
0.39368367195129395,
-0.7820587158203125,
0.13429750502109528,
0.1915159970521927,
0.658117413520813,
-0.06838395446538925,
-0.04025242105126381,
-0.040933869779109955,
0.2215494066476822,
0.34444528818130493,
-0.350318968296051,
0.018438655883073807,
-0.18630509078502655,
-0.43329089879989624,
-0.5548030138015747,
0.28650912642478943,
-0.048084814101457596,
-0.006818823982030153,
-0.27721869945526123,
-0.35963594913482666,
0.34011927247047424,
-0.13110576570034027,
-0.13156737387180328,
0.17987121641635895,
-0.43965399265289307,
-0.47523894906044006,
0.1102372258901596,
-0.6353461742401123,
0.17081288993358612,
0.3666698634624481,
0.13982567191123962,
0.6092585921287537,
-0.273516446352005,
-0.5102171301841736,
-0.38088563084602356,
0.02847161516547203,
0.3109770119190216,
-0.34277644753456116,
0.23905766010284424,
-0.2664591372013092,
-0.41817888617515564,
-0.32221320271492004,
0.8104400634765625,
-0.0551786907017231,
0.08369773626327515,
-0.032638296484947205,
-0.5741531252861023,
-0.10919429361820221,
0.04683583602309227,
-0.4399259686470032,
-0.6791350841522217,
0.25651973485946655,
-0.2073974609375
] |
[
0.030699975788593292,
0.10140369832515717,
-0.04192632809281349,
0.06293141841888428,
-0.03267847001552582,
-0.12038351595401764,
0.035765983164310455,
-0.05915536358952522,
-0.008488839492201805,
-0.05911063775420189,
-0.05657084658741951,
-0.005575065966695547,
-0.05070307105779648,
0.06654473394155502,
-0.05232572928071022,
-0.10524960607290268,
-0.11025319993495941,
0.10980250686407089,
0.11460278183221817,
-0.11366231739521027,
-0.0736834928393364,
-0.014200853183865547,
0.03315950185060501,
-0.042415086179971695,
-0.18886972963809967,
0.04834016412496567,
-0.010257190093398094,
-0.013155662454664707,
-0.11621294915676117,
0.22128282487392426,
0.026432644575834274,
-0.0035340951289981604,
0.09944672882556915,
0.0506606251001358,
0.07618589699268341,
-0.1337132453918457,
-0.07806193083524704,
0.018981769680976868,
-0.056862808763980865,
-0.14643901586532593,
-0.16388945281505585,
-0.057634275406599045,
0.07937344908714294,
-0.0544847771525383,
-0.024052107706665993,
-0.07310523092746735,
-0.07155387103557587,
-0.10090649873018265,
-0.028452187776565552,
0.14460046589374542,
-0.05908972769975662,
-0.0028850892558693886,
-0.030829090625047684,
-0.06325825303792953,
-0.02312028780579567,
-0.15990810096263885,
-0.09092682600021362,
-0.016466086730360985,
0.06645786762237549,
0.04531364515423775,
-0.11512433737516403,
0.10278821736574173,
-0.23874814808368683,
-0.08993463963270187,
0.04214683547616005,
-0.06208702549338341,
0.19159553945064545,
0.06058281660079956,
0.04147198423743248,
0.04145164415240288,
0.08241380751132965,
0.07910601049661636,
-0.21460114419460297,
-0.04764945060014725,
-0.06004532054066658,
-0.05771621689200401,
0.04311008378863335,
0.029352186247706413,
-0.007787349633872509,
0.0667465552687645,
0.11730451881885529,
-0.036040034145116806,
0.0379948653280735,
0.08618149906396866,
0.09119251370429993,
-0.12663358449935913,
-0.027850864455103874,
-0.026794370263814926,
0.10444615036249161,
-0.19966867566108704,
-0.06711355596780777,
0.020024478435516357,
0.02054487355053425,
-0.07212473452091217,
-0.12159039080142975,
-0.23648804426193237,
-0.04011392965912819,
0.10453135520219803,
-0.08162038028240204,
-0.047898195683956146,
-0.14109919965267181,
-0.09871640801429749,
0.006453124340623617,
0.08454540371894836,
-0.20008768141269684,
0.031001994386315346,
0.3166082501411438,
-0.08357764780521393,
-0.06154737249016762,
0.05468873679637909,
-0.10438451170921326,
-0.043026577681303024,
0.039880186319351196,
-0.002967559266835451,
0.04125188663601875,
0.10730873048305511,
-0.031131744384765625,
0.07599066942930222,
0.11015765368938446,
0.2026078850030899,
0.0340835340321064,
-0.11498764902353287,
0.00341621832922101,
0.1823115050792694,
0.08721653372049332,
0.08886470645666122,
0.038886621594429016,
-0.14626866579055786,
-0.10826382040977478,
-0.10755138099193573,
-0.043079130351543427,
0.06791600584983826,
-0.08626728504896164,
-0.13008858263492584,
-0.06684456765651703,
-0.0757908821105957,
-0.12930254638195038,
0.10704216361045837,
-0.16803321242332458,
0.12600107491016388,
-0.04051733389496803,
0.056915540248155594,
0.09876076132059097,
0.05756385996937752,
0.12005363404750824,
-0.09532523900270462,
-0.0735682025551796,
0.04351639747619629,
0.12305520474910736,
-0.12239664793014526,
-0.03981996327638626,
-0.02161284163594246,
-0.10828825831413269,
-0.0646689310669899,
-0.03846750035881996,
0.19904725253582,
-0.03407208248972893,
-0.10436071455478668,
0.018596051260828972,
0.10414863377809525,
0.09536723792552948,
-0.014020226895809174,
0.04361536353826523,
0.028888408094644547,
-0.06593406200408936,
0.008343683555722237,
0.04160940647125244,
-0.011753213591873646,
-0.11578797549009323,
0.05167029798030853,
-0.06676144897937775,
0.1441592276096344,
-0.22843779623508453,
0.12496988475322723,
0.028016896918416023,
-0.05906530097126961,
0.17457708716392517,
0.05070481076836586,
-0.11385047435760498,
0.060045935213565826,
-0.09621882438659668,
0.05438654124736786,
0.03432608023285866,
0.15427951514720917,
0.11706224828958511,
-0.002386678010225296,
0.00803310889750719,
-0.07359828799962997,
0.15835100412368774,
0.017626335844397545,
-0.007624693680554628,
-0.04966338351368904,
-0.04089459404349327,
0.07255762070417404,
0.21151596307754517,
0.06603258103132248,
0.09396278113126755,
-0.018833069130778313,
0.02596215531229973,
0.07787297666072845,
0.0033172147814184427,
-0.03406890109181404,
-0.0378173291683197,
0.0016285512829199433,
0.17468418180942535,
0.14436595141887665,
0.07670074701309204,
-0.018170222640037537,
-0.12715241312980652,
0.011177051812410355,
0.04855913668870926,
0.05172306299209595,
-0.04483100771903992,
-0.031188545748591423,
0.21232262253761292,
-0.12014889717102051,
0.04454215243458748,
-0.006694146431982517,
-0.008590037934482098,
0.010534912347793579,
-0.005982778966426849,
-0.049038566648960114,
-0.03788432478904724,
-0.148992121219635,
-0.15680280327796936,
0.11952607333660126,
-0.03443474322557449,
-0.009466748684644699,
-0.17385894060134888,
0.06695250421762466,
-0.08063670247793198,
0.1111515536904335,
-0.05964672192931175,
-0.08919277042150497,
0.07400178909301758,
-0.08179539442062378,
0.010917145758867264,
-0.10002771019935608,
0.030084840953350067,
-0.05879339575767517,
0.15256229043006897,
-0.0588756687939167,
0.058464743196964264,
-0.06250129640102386,
-0.1272299885749817,
0.14816193282604218,
0.11261296272277832,
-0.20878300070762634,
0.07267408818006516,
-0.19025585055351257,
0.04558248072862625,
-0.06399069726467133,
0.09287825971841812,
-0.14967121183872223,
0.0832153856754303,
0.0884755551815033,
-0.07130222767591476,
-0.08636317402124405,
-0.062446922063827515,
-0.0917036235332489,
0.04213356599211693,
0.02685438096523285,
-0.07510712742805481,
0.14564858376979828,
-0.1311965137720108,
0.06008942797780037,
0.10980391502380371,
0.23106127977371216,
0.06301818042993546,
-0.11306808888912201,
0.4958252012729645,
-0.08599810302257538,
-0.10827255249023438,
-0.07431084662675858,
0.00557404151186347,
-0.010929758660495281,
0.19725823402404785,
0.07282532006502151,
0.12956568598747253,
0.12012496590614319,
-0.32143303751945496,
-0.003951505292207003,
0.031411223113536835,
0.2858768403530121,
0.007240592502057552,
-0.04573579132556915,
-0.15110504627227783,
-0.06919705122709274,
-0.05780123919248581,
0.045537661761045456,
0.08062059432268143,
0.05595998466014862,
-0.19111478328704834,
0.20023339986801147,
0.030304836109280586,
0.16707292199134827,
-0.019236214458942413,
0.14964352548122406,
-0.0109718581661582,
0.08966008573770523,
-0.1306983232498169,
-0.10273553431034088,
0.05057602375745773,
-0.10228367894887924,
-0.014037727378308773,
0.01175781711935997,
-0.19365377724170685,
0.07810384780168533,
-0.09055490046739578,
-0.024642886593937874,
-0.007601541467010975,
0.024362703785300255,
0.1254616379737854,
-0.048288214951753616,
0.038688793778419495,
-0.023422805592417717,
-0.039048850536346436,
0.09871713072061539,
-0.12935157120227814,
-0.08097562938928604,
-0.08026036620140076,
0.09477176517248154,
-0.016387617215514183,
0.016990656033158302,
-0.08228129148483276,
-0.013419480063021183,
0.09099746495485306,
-0.12665517628192902,
-0.11556627601385117,
-0.06357208639383316,
0.13796506822109222,
-0.03748014569282532,
-0.06792362779378891,
-0.11707259714603424,
-0.03880562260746956,
0.021529851481318474,
0.1335168182849884,
-0.20159269869327545,
-0.020768262445926666,
0.03235907480120659,
0.17776764929294586,
-0.13711069524288177,
0.054383035749197006,
0.1364498734474182,
-0.0664997398853302,
-0.13668900728225708,
-0.05714643374085426,
0.06318619847297668,
-0.04915833845734596,
-0.037615757435560226,
-0.030773334205150604,
0.16446112096309662,
-0.04886315017938614,
-0.18910305202007294,
0.07617077976465225,
-0.016795340925455093,
0.09917127341032028,
-0.018028702586889267,
0.17936013638973236,
0.1950056403875351,
-0.07366102188825607,
0.06003068387508392,
-0.06908491253852844,
0.010838094167411327,
-0.01070399209856987,
-0.02660319395363331,
0.013416670262813568,
-0.06685419380664825,
-0.02624829299747944,
-0.03683823347091675,
-0.09697310626506805,
-0.18608561158180237,
0.0381377749145031,
0.14146940410137177,
-0.1311713010072708,
0.07777606695890427,
-0.01577705889940262,
-0.17565688490867615,
0.03242841362953186,
0.033038247376680374,
-0.10881786793470383,
-0.11456996947526932,
-0.020494369789958,
0.029386846348643303,
0.09281162917613983,
0.1401824951171875,
0.15178707242012024,
0.040599074214696884,
0.09011775255203247,
-0.24185405671596527,
-0.048800211399793625,
0.0538560152053833,
0.024362187832593918,
0.08835064619779587,
-0.12078657001256943,
-0.029829923063516617,
-0.050800859928131104,
-0.027568737044930458,
0.11569537967443466,
-0.08833982795476913,
-0.07752125710248947,
0.04416066035628319,
0.10488185286521912,
-0.03403449431061745,
-0.036388035863637924,
-0.028469476848840714,
0.00013972366286907345,
-0.02620040997862816,
0.019505295902490616,
0.03172631934285164,
-0.009704504162073135,
-0.008721652440726757,
0.02358195185661316,
-0.02107628993690014,
0.10953398793935776,
-0.12684720754623413,
-0.011352095752954483,
0.20320820808410645,
0.11569026112556458,
0.06384299695491791,
0.07973365485668182,
0.07756686955690384,
-0.014700566418468952,
-0.07601739466190338,
-0.15688274800777435,
0.043123140931129456,
-0.07327551394701004,
0.11937576532363892,
-0.16742980480194092,
-0.06767740845680237,
-0.032997481524944305,
0.03229013830423355,
-0.07201521098613739,
0.020497772842645645,
0.1007266715168953,
0.10656307637691498,
-0.006670929957181215,
0.045204728841781616,
-0.11228744685649872,
0.03726661205291748,
-0.09642747044563293,
-0.021383125334978104,
0.09304244816303253,
0.16754911839962006,
0.046043168753385544,
-0.06674063950777054,
0.05671413242816925,
-0.1691814512014389,
-0.09079419821500778,
0.02362711913883686,
-0.03823481500148773,
0.032727308571338654,
0.027651354670524597,
-0.06272287666797638,
0.25346511602401733,
-0.0711563304066658,
-0.09735190868377686,
0.09871630370616913,
-0.09277880936861038,
0.17078223824501038,
-0.04301628842949867,
-0.12943820655345917,
0.09328215569257736,
-0.03212863951921463,
0.07257618755102158,
-0.0919959545135498,
-0.09690722078084946,
-0.014983730390667915,
-0.02383156679570675,
0.1599690020084381,
0.2708745300769806,
0.004232767503708601,
0.06919010728597641,
-0.18598918616771698,
-0.18889376521110535,
0.12317569553852081,
0.20423759520053864,
-0.018112223595380783,
0.05860372632741928,
0.04035134240984917,
0.23361057043075562,
-0.036147184669971466,
0.09624502807855606,
0.15925373136997223,
-0.05318930000066757,
0.0999671220779419,
-0.1810319870710373,
-0.05631474032998085,
0.24686497449874878,
-0.29344862699508667,
-0.08175241202116013,
-0.1502540409564972,
0.03189156949520111,
-0.21783162653446198,
-0.0316685251891613,
0.0770697370171547,
0.011430091224610806,
-0.20418010652065277,
0.12323997914791107,
-0.05420595780014992,
-0.06644335389137268,
0.017708318307995796,
-0.031245650723576546,
-0.069255530834198,
0.029646968469023705,
-0.010673110373318195,
-0.043574053794145584,
0.04528564214706421,
-0.010181069374084473,
0.17210781574249268,
-0.11144612729549408,
-0.03275112062692642,
-0.01416890136897564,
-0.11918938905000687,
0.16780740022659302,
-0.04347151517868042,
-0.07990653067827225,
-0.1383093297481537,
-0.07701651751995087,
0.13612787425518036,
0.06718118488788605,
-0.03026001900434494,
-0.10584010183811188,
0.1504666954278946,
0.04537953436374664,
-0.04277321323752403,
-0.07999415695667267,
-0.05302651226520538,
0.06232829764485359,
-0.06967832148075104,
0.006939463783055544,
0.03764990344643593,
-0.16889509558677673,
-0.0128104779869318,
-0.12893931567668915,
0.004090023227035999,
-0.10927903652191162,
0.02363210916519165,
-0.0021094942931085825,
0.09061166644096375,
-0.15584534406661987,
0.10387682914733887,
-0.05615909397602081,
-0.08126594126224518,
-0.12864066660404205,
-0.10040390491485596,
0.049997348338365555,
-0.06948837637901306,
-0.2262738049030304,
0.07372745871543884,
-0.0751219317317009,
-0.023589715361595154,
0.0006566792726516724,
0.015917714685201645,
0.015185697935521603,
0.1439286172389984,
-0.048737782984972,
0.04775804653763771,
-0.03251831233501434,
-0.08096536993980408,
0.11022157967090607,
0.08137879520654678,
0.06090184673666954,
-0.00013641569239553064,
-0.08019585907459259,
0.029292188584804535,
0.0633009821176529,
-0.12884356081485748,
0.08761142194271088,
0.026820791885256767,
-0.08458266407251358,
0.07295160740613937,
0.15415427088737488,
-0.0795522928237915,
0.11442394554615021,
0.02001115493476391,
0.09106463938951492,
-0.016615290194749832,
-0.21292705833911896,
0.10298934578895569,
0.05502275377511978,
0.0073677487671375275,
-0.2833021283149719,
0.02874218113720417,
-0.11885728687047958,
0.14102113246917725,
0.07653405517339706,
0.09427811205387115,
-0.18969523906707764,
0.029876410961151123,
0.09227520227432251,
-0.013809707947075367,
-0.19043710827827454,
0.2721906006336212,
-0.09463087469339371,
0.16874489188194275,
-0.0929885283112526,
-0.20977464318275452,
0.11410222947597504,
-0.24532605707645416,
0.1033991351723671,
-0.10767566412687302,
0.1346479207277298,
0.04692460969090462,
-0.06546223908662796,
-0.06456930190324783,
-0.016968602314591408,
-0.17973142862319946,
0.006486006546765566,
0.12100864946842194,
0.16770276427268982,
0.09269894659519196,
-0.02782367542386055,
0.08303628861904144,
-0.01005392987281084,
0.12554210424423218,
-0.0039508226327598095,
0.06577645242214203,
-0.16509583592414856,
0.04058369994163513,
-0.1464710533618927,
0.06944134086370468,
0.004074519500136375,
0.030400428920984268,
-0.23784418404102325,
-0.16445674002170563,
0.17691773176193237,
-0.04592552036046982,
-0.12712617218494415,
-0.0823761522769928,
0.09494348615407944,
0.1738746613264084,
0.09308170527219772,
-0.06952536106109619,
-0.018745578825473785,
0.057547252625226974,
0.07872483134269714,
0.09157146513462067,
0.04403744265437126,
0.016956856474280357,
-0.09269630163908005,
-0.029361916705965996,
-0.06743098795413971,
-0.28720706701278687,
0.07613074034452438,
0.005947081837803125,
-0.04800977557897568,
0.05805841088294983,
-0.22678130865097046,
0.00736323744058609,
-0.036018453538417816,
-0.09721697121858597,
0.21445755660533905,
0.14375033974647522,
-0.037552669644355774,
0.07481253147125244,
0.047465730458498,
0.12795665860176086,
0.0499894879758358,
0.3371717631816864,
0.1206621453166008,
0.04664211347699165,
0.07534867525100708,
0.11638755351305008,
-0.1137082502245903,
-0.01809467002749443,
0.027630813419818878,
-0.07026474177837372,
0.10068340599536896,
-0.033441174775362015,
-0.02745586819946766,
-0.09059090167284012,
-0.016674429178237915,
-0.09251946210861206,
-0.1066908910870552,
-0.14217059314250946,
-0.0029501612298190594,
-0.10616209357976913,
-0.12213589251041412,
0.23970355093479156,
-0.06059916317462921,
0.09325772523880005,
-0.027130169793963432,
0.08298519998788834,
-0.11706145107746124,
-0.025369465351104736,
0.02586756832897663,
-0.10644304752349854,
0.07422038167715073,
0.011267676949501038,
0.040812499821186066,
0.11823710054159164,
-0.12311052531003952,
0.036918528378009796,
-0.09282504767179489,
-0.07867162674665451,
0.09925122559070587,
0.00831183698028326,
0.07572954893112183,
0.18012267351150513,
-0.11015387624502182,
0.25394564867019653,
0.0647750273346901,
-0.010540131479501724,
-0.14140892028808594,
0.09216330945491791,
0.14021435379981995,
-0.07399103045463562,
0.030010830610990524,
-0.0632258877158165,
0.026569640263915062,
-0.31273141503334045,
0.09507186710834503,
0.048706747591495514,
0.03564697876572609,
0.0877167135477066,
0.044927213340997696,
0.0967792421579361,
-0.12211425602436066,
-0.1670200675725937,
0.09019871801137924,
0.036771178245544434,
-0.01080002449452877,
0.07695483416318893,
0.17063258588314056,
0.04803616926074028,
-0.10535462200641632,
0.06133848801255226,
0.10331029444932938,
-0.0652971938252449,
0.12990865111351013,
0.06802456825971603,
0.031069843098521233,
-0.06295310705900192,
-0.0010956355836242437,
-0.042811691761016846,
0.05890437588095665,
-0.03734767809510231,
-0.0005172397359274328,
0.023220261558890343,
-0.13965068757534027,
-0.07897917926311493,
-0.0788731500506401,
0.023132644593715668,
0.04229813814163208,
0.0890314057469368,
-0.07917604595422745,
-0.03219835087656975,
0.1405557245016098,
-0.03651417791843414,
-0.04889789968729019,
0.03253275156021118,
-0.08247864246368408,
-0.03458242863416672,
-0.04264979436993599,
-0.04301273822784424,
-0.09590031951665878,
0.13572357594966888,
0.0012255808105692267,
0.16827429831027985,
0.0843420997262001,
-0.09352738410234451,
0.03125839680433273,
-0.28809845447540283,
0.08971253037452698,
-0.049394357949495316,
0.11219234764575958,
-0.16251173615455627
] | [
-0.6405137181282043,
-0.40237531065940857,
-0.4379032552242279,
0.4858168959617615,
0.026843443512916565,
0.8250871896743774,
0.591051459312439,
0.49869590997695923,
-0.05352409556508064,
-0.5380819439888,
-0.030063176527619362,
0.1934276521205902,
-0.17665459215641022,
-0.2884982228279114,
0.21587994694709778,
0.6314683556556702,
0.07805005460977554,
0.01826055534183979,
0.7228599190711975,
-0.17166107892990112,
0.09680569171905518,
-0.02651747688651085,
0.3800112009048462,
0.005414656829088926,
-0.27775484323501587,
-0.3200223743915558,
-0.5080534815788269,
-0.2075829803943634,
-0.3583580255508423,
0.2830114960670471,
-0.5827750563621521,
0.12257585674524307,
0.436928391456604,
0.3532000184059143,
0.564717710018158,
0.048827674239873886,
-0.07594364136457443,
-0.12622830271720886,
0.053892455995082855,
0.07402795553207397,
-0.5602610111236572,
0.11546620726585388,
0.21992602944374084,
0.2670930027961731,
0.18983040750026703,
-0.04674329236149788,
-1.2200636863708496,
0.3175443112850189,
-0.17276346683502197,
-0.8183501362800598,
-0.5250676274299622,
-0.19748036563396454,
0.3238544166088104,
0.5963900089263916,
0.11509183794260025,
-0.107943594455719,
0.35183751583099365,
0.2924298644065857,
-0.15422554314136505,
0.19241882860660553,
0.8530176877975464,
0.5063220262527466,
0.34927883744239807,
0.2658578157424927,
-0.23652294278144836,
0.05941621586680412,
0.42366692423820496,
0.050829172134399414,
-0.19484123587608337,
-0.711532711982727,
0.17822271585464478,
0.7535077333450317,
0.14014923572540283,
0.10093405097723007,
-0.3228948712348938,
0.20055116713047028,
-0.19007807970046997,
0.28901323676109314,
0.10063039511442184,
-0.03848069906234741,
-0.1955675482749939,
-0.8078544735908508,
0.04586132615804672,
-0.11808034032583237,
-0.24477964639663696,
-0.40330132842063904,
0.8196008801460266,
-0.13639597594738007,
-0.9123497605323792,
0.4288228750228882,
-0.7800590991973877,
0.031614482402801514,
0.29552367329597473,
0.5088914632797241,
0.5439472794532776,
-0.18054720759391785,
-0.21971161663532257,
-0.05083504319190979,
0.6170822978019714,
-0.712860107421875,
-0.5503864288330078,
-0.9498862028121948,
-0.5838750004768372,
-0.03559653460979462,
-0.6456656455993652,
0.021811138838529587,
-1.0994744300842285,
0.11977823823690414,
-0.3225787580013275,
0.3308296799659729,
-0.7427442669868469,
-0.19227683544158936,
0.3549487292766571,
0.19111023843288422,
-0.39548635482788086,
-0.023019053041934967,
-0.0343155562877655,
-0.17994794249534607,
-0.1811835765838623,
-0.1845594048500061,
-0.005594165064394474,
0.1260816603899002,
-0.17074158787727356,
0.2197311520576477,
-0.20783691108226776,
0.035901594907045364,
-0.366798460483551,
0.30805057287216187,
-0.12659867107868195,
0.17417366802692413,
-0.03723131865262985,
-0.23911958932876587,
-0.2008027583360672,
0.026582183316349983,
-0.21551357209682465,
-0.5486097931861877,
-0.21325384080410004,
0.052347972989082336,
-0.03783343732357025,
0.07125475257635117,
-0.13377344608306885,
0.008458757773041725,
0.27349352836608887,
-0.34788942337036133,
0.39084601402282715,
-0.6821686029434204,
-0.6143672466278076,
0.24633195996284485,
-0.7538977265357971,
0.05913751944899559,
0.25489965081214905,
0.35555312037467957,
-0.1638355553150177,
0.3167976140975952,
0.3675808012485504,
0.3050578832626343,
0.007362578995525837,
-0.15388232469558716,
-0.3047502338886261,
-0.0821155235171318,
0.35859501361846924,
0.6810493469238281,
0.2259669452905655,
-0.08428235352039337,
0.7316536903381348,
-0.22368060052394867,
-0.6080368161201477,
0.48941099643707275,
-0.19647999107837677,
0.2771236002445221,
-0.5139791965484619,
-0.662840723991394,
0.27492234110832214,
-0.1847514808177948,
-0.250088095664978,
0.48996007442474365,
0.2121702879667282,
0.3231496810913086,
0.4580309987068176,
-0.3447554409503937,
-0.23925529420375824,
0.034911416471004486,
-0.20812639594078064,
0.06909839808940887,
0.10304594039916992,
-0.3709271252155304,
0.7266157865524292,
-0.01675555296242237,
0.24747776985168457,
-0.05028047785162926,
-0.44722867012023926,
0.11035291850566864,
0.42860254645347595,
0.007925187237560749,
0.03177899494767189,
-0.14207139611244202,
0.025058120489120483,
-0.006179651711136103,
-0.5869449973106384,
-0.5620450377464294,
-0.08105451613664627,
-0.01896088942885399,
0.08508529514074326,
-0.06164143607020378,
-0.6453149318695068,
0.2898566424846649,
-0.19194786250591278,
-0.8347829580307007,
-0.17305921018123627,
0.16413678228855133,
-0.01736634038388729,
0.29173094034194946,
-0.31920695304870605,
0.2484014332294464,
0.03193426504731178,
-0.05750153586268425,
-0.5523152947425842,
-0.37817129492759705,
-0.031182529404759407,
0.010498217307031155,
0.6141337156295776,
0.005562508013099432,
0.5754885673522949,
0.09742695093154907,
0.24905730783939362,
0.595888614654541,
0.3569446802139282,
-0.04178495332598686,
0.2616642415523529,
-0.33417198061943054,
-0.44338324666023254,
-0.18796509504318237,
-0.07724089920520782,
0.09030621498823166,
-0.18053226172924042,
-0.038269173353910446,
0.2791324555873871,
-0.3814674913883209,
0.440965473651886,
-0.4539218246936798,
-0.437311589717865,
0.27674201130867004,
-0.39244967699050903,
0.32035577297210693,
-0.34466156363487244,
0.2573222815990448,
0.030993448570370674,
0.2983739972114563,
-0.009839211590588093,
-0.38673514127731323,
0.11693607270717621,
-0.066309355199337,
-0.4121782183647156,
-0.1592489331960678,
0.7279937863349915,
-0.3668922781944275,
-0.6626343131065369,
-0.6304081082344055,
0.43349120020866394,
0.1777256727218628,
-0.11462395638227463,
0.4747953712940216,
0.04924236983060837,
-0.6568655371665955,
0.10712870955467224,
-0.2694474160671234,
-1.0508304834365845,
-1.1156034469604492,
0.39187684655189514,
-0.21080021560192108,
0.3013175129890442,
-0.02215932123363018,
-0.2811366319656372,
-0.37139707803726196,
-0.48152124881744385,
0.3146005868911743,
-0.023905877023935318,
0.2040567845106125,
-0.2825774848461151,
-0.6946139335632324,
0.10420634597539902,
0.7348901629447937,
-0.4308755397796631,
-0.3500937521457672,
-0.7078908085823059,
0.032581526786088943,
-0.06528077274560928,
-0.14389154314994812,
0.4443519115447998,
-0.3639358878135681,
-0.5161067247390747,
0.380062073469162,
0.3595781922340393,
0.2841747999191284,
-0.1788645088672638,
-0.1404784470796585,
-0.35559791326522827,
0.7628968358039856,
0.7743830680847168,
-0.26581716537475586,
0.2301884889602661,
0.248964324593544,
0.04240370914340019,
0.33601459860801697,
0.686220645904541,
-0.11663446575403214,
0.05191066861152649,
0.05023445561528206,
-5.926717758178711,
0.15985824167728424,
0.41227540373802185,
0.03696600720286369,
-0.06717564165592194,
-0.685660183429718,
-0.4523402154445648,
-0.00650072330608964,
0.6943573951721191,
-0.029640253633260727,
-0.2096613347530365,
-0.25302255153656006,
-0.2442178875207901,
0.3812408447265625,
0.215958833694458,
0.19777575135231018,
0.4026188850402832,
-0.5023983120918274,
0.30367109179496765,
0.43691158294677734,
0.02853456512093544,
0.1861387938261032,
-0.08519032597541809,
0.40896081924438477,
-0.1732265204191208,
0.446936696767807,
-0.3138706386089325,
0.4826297461986542,
-0.7074016332626343,
-0.14766176044940948,
-0.5846761465072632,
-0.09030564874410629,
-0.591183602809906,
-0.501499593257904,
-0.005868382286280394,
0.3856718838214874,
-0.028344735503196716,
-0.19734036922454834,
0.5262187719345093,
0.26671701669692993,
-0.3591674566268921,
0.4326573610305786,
-0.2670843005180359,
0.5088358521461487,
0.3468944728374481,
0.278751939535141,
0.9903849363327026,
0.050294771790504456,
-0.24699676036834717,
0.21231505274772644,
0.2671973407268524,
0.200454980134964,
0.8399147987365723,
-0.1555546373128891,
0.14770430326461792,
0.22617369890213013,
-0.34804847836494446,
-0.7687944769859314,
0.28784874081611633,
-0.1287899911403656,
-0.20163242518901825,
-0.1705934703350067,
0.31160253286361694,
0.3891797363758087,
-0.6762845516204834,
-0.03927423804998398,
-0.24367013573646545,
0.7660377025604248,
0.6083751916885376,
-0.11142442375421524,
0.4186219871044159,
0.13385175168514252,
-0.10049636662006378,
-0.7557066679000854,
-0.07680846005678177,
-0.09487045556306839,
-0.030416471883654594,
-0.056824762374162674,
-0.49155884981155396,
-0.19291633367538452,
-0.1154153123497963,
-0.0441974475979805,
0.0636155754327774,
0.12494843453168869,
0.5879583358764648,
-0.5662126541137695,
0.04872671514749527,
0.01690656691789627,
-0.14738738536834717,
0.15299998223781586,
-0.4060676395893097,
-1.2508771419525146,
0.4381316006183624,
-0.48191437125205994,
0.8022720813751221,
0.5865172743797302,
-0.029726622626185417,
0.0035025940742343664,
0.30741146206855774,
-0.19067350029945374,
0.10247617214918137,
0.15762104094028473,
-0.29479309916496277,
0.2469588965177536,
-0.14295031130313873,
0.6153372526168823,
-0.2612922787666321,
0.410405695438385,
0.3434380888938904,
-0.9637153744697571,
0.37005409598350525,
0.8671360015869141,
-0.07724590599536896,
0.5419739484786987,
-0.22870415449142456,
-0.195687398314476,
-0.13765989243984222,
-0.11901091784238815,
-0.3170420229434967,
-0.813113808631897,
-0.09001196175813675,
0.2522040605545044,
-0.1321377009153366,
-0.44381189346313477,
-0.1272321492433548,
0.337159663438797,
-0.034877993166446686,
-0.18754339218139648,
0.10602138191461563,
0.9518159627914429,
0.4172194004058838,
0.08056331425905228,
0.23670290410518646,
-0.26023632287979126,
0.598850429058075,
0.0900973454117775,
0.13066397607326508,
-0.677077054977417,
-0.3661991357803345,
0.04574254900217056,
0.3012562394142151,
0.02984621934592724,
-0.04079459235072136,
-0.1463468372821808,
0.3255300521850586,
-0.3803701400756836,
0.16178934276103973,
-0.2730391025543213,
-0.1169378012418747,
-0.32213449478149414,
-0.026793222874403,
-0.11395637691020966,
0.5738397836685181,
-0.14538982510566711,
-0.12061220407485962,
-0.4149736762046814,
-0.04234865680336952,
-0.3475729525089264,
-0.343759149312973,
-0.43574774265289307,
0.4395364224910736,
-0.5820834040641785,
-0.03472289443016052,
0.03676805645227432,
0.13348166644573212,
-0.3336793780326843,
-0.10264715552330017,
0.0874810665845871,
0.27708879113197327,
-0.2545282542705536,
-0.018138179555535316,
-0.6050015687942505,
0.09920167922973633,
0.16164147853851318,
0.14675846695899963,
0.012121990323066711,
-0.3198172152042389,
0.01902514323592186,
-0.26108139753341675,
0.07013783603906631,
-0.22209352254867554,
-0.2217928171157837,
-0.3744063675403595,
0.4201135039329529,
-0.04484299197793007,
0.3405519723892212,
-0.7450613975524902,
0.024716639891266823,
0.45330923795700073,
0.6937953233718872,
0.0752611756324768,
-0.832017183303833,
-0.045036546885967255,
0.5537779331207275,
-0.18164633214473724,
-0.35486695170402527,
0.25607869029045105,
-0.2295973151922226,
-0.02589963562786579,
-0.12025386095046997,
0.1403854638338089,
-0.2387540489435196,
-0.2451774626970291,
0.13782870769500732,
-0.5679054260253906,
-0.41225868463516235,
0.4581570625305176,
-0.20775218307971954,
-0.23662292957305908,
0.04961321875452995,
-0.18901465833187103,
-0.6870233416557312,
-0.5773178935050964,
0.18307825922966003,
-0.2945728302001953,
-0.38617920875549316,
-0.22496278584003448,
0.015849879011511803,
-0.268669992685318,
-0.2749374806880951,
0.03696984052658081,
-0.8148856163024902,
-0.38810479640960693,
-0.025172395631670952,
-0.1502196341753006,
0.04896705970168114,
0.22394172847270966,
-0.05397177115082741,
0.2469419240951538,
-0.03264225274324417,
-0.42337819933891296,
1.041951298713684,
-0.23077920079231262,
0.5565585494041443,
-0.31003889441490173,
0.608592689037323,
-0.7702485918998718,
0.08621510863304138,
-0.6096031665802002,
-0.02853826992213726,
0.29969823360443115,
0.2085707187652588,
-0.4000083804130554,
0.6077346205711365,
-0.518153965473175,
0.34654539823532104,
0.28409817814826965,
-0.6033403873443604,
-0.05450035631656647,
0.4529287815093994,
-0.6848151683807373,
0.0723842903971672,
0.20467908680438995,
-0.10367891937494278,
0.44089752435684204,
-0.36706554889678955,
0.18545079231262207,
-0.10165735334157944,
0.12503987550735474,
-0.046692509204149246,
-0.07009854167699814,
0.18909285962581635,
0.35962802171707153,
0.08282849192619324,
0.04460080713033676,
0.0568276047706604,
0.6421523094177246,
0.2641369700431824,
0.06410586833953857,
0.27596914768218994,
0.29972729086875916,
-0.7036498188972473,
-0.16414666175842285,
0.033663712441921234,
0.07351209223270416,
0.20434892177581787,
-0.46359142661094666,
-0.5439566373825073,
-0.9238333106040955,
0.7518335580825806,
-0.23520536720752716,
0.1129995658993721,
-0.23092907667160034,
0.11087613552808762,
-0.09935221821069717,
-0.9354085326194763,
0.16645683348178864,
0.17975454032421112,
-0.5378636717796326,
-0.5492104291915894,
0.41337937116622925,
0.5800880789756775,
0.10638631135225296,
-0.33817175030708313,
0.5746670961380005,
-0.022355975583195686,
-0.2026936411857605,
0.31927573680877686,
0.40780094265937805,
-0.05101113021373749,
-0.13658465445041656,
-0.8546320796012878,
-0.2016657441854477,
0.03351324796676636,
-0.1771748811006546,
-0.37395960092544556,
-0.03345078229904175,
-0.6526021361351013,
0.12836319208145142,
0.1983776092529297,
0.6344493627548218,
-0.4830472469329834,
0.00027233120636083186,
0.5377674102783203,
0.24042531847953796,
-0.018643002957105637,
0.20486709475517273,
-0.12828630208969116,
0.4258779287338257,
0.036379870027303696,
-0.12309711426496506,
0.968438446521759,
0.34873682260513306,
-0.10962457954883575,
-0.2355499267578125,
0.5139114856719971,
0.04202704504132271,
0.39189770817756653,
-0.1655423492193222,
0.05406373739242554,
0.7246348261833191,
0.09051239490509033,
0.22606003284454346,
0.4750409722328186,
-0.2502919137477875,
-0.41616392135620117,
0.3024485409259796,
-0.09973996132612228,
0.31970423460006714,
0.7033059597015381,
-0.14586137235164642,
-0.6549742221832275,
0.41837021708488464,
0.5309693217277527,
-0.09886568039655685,
0.3642052412033081,
0.17431573569774628,
0.18348105251789093,
-0.7551875710487366,
0.7793015241622925,
0.3865963816642761,
0.42172300815582275,
0.010295970365405083,
0.6963356733322144,
-0.21687792241573334,
-0.13037286698818207,
0.6820765137672424,
-0.027327176183462143,
-0.17987865209579468,
-0.07623502612113953,
0.5820028185844421,
0.35144758224487305,
0.09853458404541016,
-0.41020703315734863,
-1.1194757223129272,
0.6177181005477905,
0.2997124493122101,
-0.031544096767902374,
-0.06057187542319298,
-0.3863482177257538,
-0.5932437181472778,
-0.016541818156838417,
-0.17606118321418762,
0.8261231780052185,
0.457338809967041,
0.6508395075798035,
-0.0012006243923678994,
0.5394740104675293,
0.15253518521785736,
0.1912892609834671,
-0.43653446435928345,
0.17960892617702484,
-0.6596009135246277,
-0.2381877303123474,
0.01935752108693123,
-0.3261159658432007,
-0.1887521892786026,
0.29278498888015747,
0.3507181704044342,
0.19733290374279022,
-0.1805429607629776,
0.6191128492355347,
0.22348980605602264,
0.17281083762645721,
-0.2651877999305725,
-0.0181918703019619,
0.0824960470199585,
0.4466002881526947,
-0.030238976702094078,
0.28071486949920654,
0.23278141021728516,
0.2960681915283203,
0.18854571878910065,
0.32386285066604614,
-0.22935795783996582,
0.16373533010482788,
-0.31030547618865967,
0.3944079577922821,
-0.10205652564764023,
-0.27200567722320557,
0.2351718693971634,
0.1578563153743744,
-0.4197356700897217,
0.30079665780067444,
0.5369536876678467,
-0.018321508541703224,
-0.19461378455162048,
-0.057749275118112564,
0.5191723704338074,
-0.5366772413253784,
-0.2823029160499573,
-0.30010727047920227,
0.48116350173950195,
0.5730797052383423,
0.4100930392742157,
0.7864708304405212,
-0.25818997621536255,
0.06303063780069351,
-0.14138896763324738,
0.10440759360790253,
-0.022119775414466858,
-0.05415227636694908,
-0.4690716862678528,
-0.0709342360496521,
-0.22036102414131165,
-0.42220842838287354,
0.48474106192588806,
-0.46471768617630005,
0.4343828856945038,
-0.17350706458091736,
-0.04658008739352226,
0.04700089618563652,
0.530000627040863,
-0.028570136055350304,
0.434516042470932,
-0.6207054853439331,
0.6326807737350464,
0.35986989736557007,
-0.19263778626918793,
0.8151133060455322,
-0.0821625366806984,
-0.09531925618648529,
0.04366768151521683,
-0.11371362954378128,
0.5795555710792542,
-0.13917334377765656,
-0.04046087712049484,
-0.2095411717891693,
0.17678895592689514,
0.14281535148620605
] |
|
BACKGROUND: Over the past decade there has been increasing interest in the use of lactic acid bacteria as mucosal delivery vehicles for vaccine antigens, microbicides and therapeutics. We investigated the mechanism by which a mucosal vaccine based in recombinant lactic acid bacteria breaks the immunological tolerance of the gut in order to elicit a protective immune response. METHODOLOGY/PRINCIPAL FINDINGS: We analyzed how the lipid modification of OspA affects the localization of the antigen in our delivery vehicle using a number of biochemistry techniques. Furthermore, we examined how OspA-expressing L. plantarum breaks the oral tolerance of the gut by stimulating human intestinal epithelial cells, peripheral blood mononuclear cells and monocyte derived dendritic cells and measuring cytokine production. We show that the leader peptide of OspA targets the protein to the cell envelope of L. plantarum, and it is responsible for protein export across the membrane. Mutation of the lipidation site in OspA redirects protein localization within the cell envelope. Further, we show that lipidated-OspA-expressing L. plantarum does not induce secretion of the pro-inflammatory cytokine IL-8 by intestinal epithelial cells. In addition, it breaks oral tolerance of the gut via Th1/Th2 cell mediated immunity, as shown by the production of pro- and anti-inflammatory cytokines by human dendritic cells, and by the production of IgG2a and IgG1 antibodies, respectively. CONCLUSIONS/SIGNIFICANCE: Lipid modification of OspA expressed in L. plantarum modulates the immune response to this antigen through a Th1/Th2 immune response. | [
0.016429344192147255,
0.011980971321463585,
0.0008472877671010792,
0.01202764268964529,
0.024632958695292473,
-0.01804118975996971,
0.009497663006186485,
0.005944851785898209,
-0.014942722395062447,
-0.019605880603194237,
0.005919181741774082,
0.021900763735175133,
0.004303828813135624,
0.01831791177392006,
0.02446070685982704,
-0.011556090787053108,
-0.014685157686471939,
0.00624773558229208,
0.015983527526259422,
0.02221057005226612,
0.019188417121767998,
-0.0006403601728379726,
0.010715309530496597,
0.01034422405064106,
0.010441632941365242,
0.024563686922192574,
-0.018442006781697273,
0.01755480468273163,
-0.010476116091012955,
0.020979175344109535,
0.011126220226287842,
0.0043335044756531715,
-0.003980760462582111,
-0.014516380615532398,
-0.00537207443267107,
0.006265856325626373,
-0.0026824618689715862,
0.025424908846616745,
0.02142362669110298,
-0.0030264011584222317,
-0.0010712796356528997,
-0.013888444751501083,
0.0005546648753806949,
-0.016540132462978363,
-0.007897117175161839,
-0.020284462720155716,
0.0002667974913492799,
-0.008037693798542023,
0.01887332834303379,
0.0004022949724458158,
-0.0018694016616791487,
-0.028182419016957283,
-0.011761835776269436,
-0.001039295457303524,
-0.0064858328551054,
-0.011792412027716637,
0.020355839282274246,
-0.030959557741880417,
0.023938264697790146,
-0.0003132836427539587,
0.019965292885899544,
-0.017732784152030945,
-0.01997542753815651,
-0.02290424332022667,
0.007557438686490059,
-0.06648136675357819,
0.02124343253672123,
0.021979989483952522,
0.0200349073857069,
0.013016799464821815,
-0.01665217988193035,
0.014517532661557198,
-0.01280256174504757,
0.001987999305129051,
-0.0017208936624228954,
-0.013504978269338608,
-0.008468144573271275,
0.02016441524028778,
0.01256484817713499,
0.016736725345253944,
-0.02061302214860916,
-0.0036367119755595922,
0.008232174441218376,
0.01869296096265316,
0.010642625391483307,
0.004317072685807943,
-0.019156064838171005,
-0.003801190759986639,
0.01391464564949274,
-0.012525687925517559,
0.0030238411854952574,
-0.0014938097447156906,
-0.021092144772410393,
-0.004859133157879114,
-0.02422722429037094,
0.005935091525316238,
-0.009091436862945557,
-0.023226898163557053,
-0.0029243165627121925,
-0.012855970300734043,
-0.008061256259679794,
0.01351204700767994,
0.012722715735435486,
0.0022769758943468332,
-0.00860548671334982,
0.008537420071661472,
-0.003469557035714388,
0.01927102915942669,
0.007513787131756544,
0.010323400609195232,
-0.006553721614181995,
-0.032908495515584946,
-0.008470752276480198,
0.006179471500217915,
-0.006193944253027439,
0.021433372050523758,
0.01030937023460865,
0.020546618849039078,
0.021402638405561447,
-0.03014213591814041,
0.01360675971955061,
-0.012654084712266922,
0.004933484829962254,
-0.01173722930252552,
0.004584844224154949,
0.00943206436932087,
-0.011426215060055256,
0.0083751380443573,
0.014169869013130665,
0.013104110956192017,
-0.008034545928239822,
0.004900035448372364,
-0.0042687528766691685,
0.0004801072645932436,
0.00420042360201478,
0.013610133901238441,
0.0018703879322856665,
-0.03903263807296753,
0.010599661618471146,
-0.023128345608711243,
-0.017039820551872253,
0.010916756466031075,
-0.00085126340854913,
0.007389610167592764,
0.011988451704382896,
-0.001307957572862506,
0.008251597173511982,
0.00032946281135082245,
0.029251977801322937,
-0.01125715859234333,
0.008510898798704147,
-0.004396856762468815,
-0.03770646080374718,
-0.01360239926725626,
0.009770319797098637,
0.0504436194896698,
-0.0077364481985569,
-0.04394402727484703,
-0.006206392776221037,
0.03651785850524902,
0.032654229551553726,
-0.05317239463329315,
0.025188898667693138,
0.011068349704146385,
0.016467249020934105,
0.015383285470306873,
0.01951846480369568,
-0.014214792288839817,
0.007048312574625015,
0.004082057625055313,
-0.0037338752299547195,
-0.003321782685816288,
-0.002609346993267536,
0.010676387697458267,
-0.0015622209757566452,
-0.00695699080824852,
0.01789727993309498,
0.008074717596173286,
-0.012643750756978989,
0.06596669554710388,
0.006515403278172016,
-0.007561196573078632,
0.01078062690794468,
0.0037697877269238234,
0.02716551534831524,
-0.014648188836872578,
0.033726610243320465,
-0.0016432458069175482,
-0.01322096586227417,
0.00015530851669609547,
0.004295895341783762,
-0.010649682022631168,
-0.01892952062189579,
0.007189874537289143,
-0.00861804187297821,
0.00221965997479856,
-0.0010295147076249123,
0.0017841756343841553,
-0.014518409967422485,
-0.020085349678993225,
0.05476552993059158,
-0.0040143998339772224,
0.03785024210810661,
-0.015082381665706635,
-0.009329965338110924,
0.019777270033955574,
-0.033245645463466644,
-0.013308173045516014,
-0.009328646585345268,
0.004058242775499821,
0.030187856405973434,
-0.02835812419652939,
-0.00830224808305502,
-0.002509691519662738,
-0.01183630432933569,
0.0018136270809918642,
0.010727363638579845,
-0.03253190964460373,
0.014888042584061623,
-0.01509180013090372,
-0.0015964240301400423,
0.0026400727219879627,
-0.027413224801421165,
-0.0007683392614126205,
0.01209656149148941,
0.027187980711460114,
0.011788462288677692,
0.013800891116261482,
-0.01133355125784874,
-0.010315649211406708,
-0.0008359188213944435,
-0.03261912986636162,
-0.017013052478432655,
0.008026514202356339,
-0.02345031499862671,
-0.01046428270637989,
0.014892691746354103,
0.00699979905039072,
0.015095293521881104,
-0.016022158786654472,
0.010915548540651798,
0.013973109424114227,
0.03488105162978172,
0.021401235833764076,
-0.021425779908895493,
-0.011972898617386818,
0.004906842485070229,
0.008511511608958244,
0.018255582079291344,
-0.020719652995467186,
0.007173597812652588,
0.0107180867344141,
0.0010332968086004257,
-0.04196508228778839,
0.019675644114613533,
-0.016068384051322937,
-0.023214083164930344,
0.027307141572237015,
0.02341386303305626,
0.00960504449903965,
0.00007592560723423958,
0.00787523202598095,
-0.04366151615977287,
-0.0058649443089962006,
-0.0009119831956923008,
0.03094921074807644,
-0.0011537563987076283,
0.027726367115974426,
-0.008318427950143814,
0.006807477213442326,
0.01109461858868599,
-0.004168554674834013,
-0.003829683642834425,
-0.08163370192050934,
-0.013380642049014568,
-0.01563051901757717,
-0.025920996442437172,
0.013648983091115952,
-0.010703125968575478,
0.004641365259885788,
-0.000022055115550756454,
-0.004983963444828987,
0.034640632569789886,
0.003530769143253565,
0.00498376926407218,
-0.009965209290385246,
0.0003808046458289027,
-0.010634776204824448,
-0.017750797793269157,
0.014061273075640202,
-0.01499263197183609,
0.002380717545747757,
-0.020110897719860077,
0.02208641543984413,
0.0011086978483945131,
0.03413493186235428,
0.002370747271925211,
-0.04408630356192589,
0.005963082890957594,
-0.0014133119257166982,
0.001490265829488635,
0.009209856390953064,
0.009207576513290405,
-0.016094597056508064,
0.01946115866303444,
0.014330408535897732,
0.0038658962585031986,
0.018522247672080994,
-0.0008751138811931014,
-0.008993162773549557,
-0.014286702498793602,
-0.013128615915775299,
0.029951021075248718,
-0.016978731378912926,
0.014572858810424805,
0.021845854818820953,
-0.006016712635755539,
0.022157792001962662,
0.015019720420241356,
0.014764975756406784,
0.008376866579055786,
0.015293441712856293,
-0.022287851199507713,
-0.01555919274687767,
-0.0025467276573181152,
0.007217829581350088,
0.01923009753227234,
-0.012334028258919716,
-0.029623351991176605,
-0.04544341191649437,
0.030716607347130775,
-0.009985363110899925,
0.0008767930557951331,
-0.025136621668934822,
-0.038948334753513336,
0.011668464168906212,
0.030571317300200462,
0.0064474171958863735,
0.0025601694360375404,
0.015706676989793777,
-0.017000341787934303,
0.013265551067888737,
0.01842556521296501,
-0.0017205961048603058,
0.0023237571585923433,
-0.017141079530119896,
-0.0038672657683491707,
-0.0008060140535235405,
-0.007384687662124634,
-0.01072799414396286,
-0.005250613205134869,
0.010972745716571808,
-0.008134884759783745,
0.012488082982599735,
-0.005095337051898241,
-0.010266992263495922,
0.0030316291376948357,
-0.004552967846393585,
-0.007068744394928217,
0.002023733453825116,
0.01645737886428833,
-0.004739235620945692,
-0.015432236716151237,
-0.008924560621380806,
0.014852739870548248,
-0.03742082417011261,
0.0076536452397704124,
0.01353827677667141,
-0.00027410220354795456,
-0.019589297473430634,
0.010081816464662552,
-0.008151121437549591,
0.008513811975717545,
-0.006214553024619818,
-0.006024415139108896,
-0.01928505301475525,
-0.004504411015659571,
-0.017122255638241768,
0.01499154232442379,
0.004716853145509958,
-0.011050721630454063,
-0.00835488736629486,
-0.014627501368522644,
0.018199676647782326,
-0.013345920480787754,
-0.0054852524772286415,
-0.010394499637186527,
0.015279974788427353,
-0.02024199441075325,
0.003437102772295475,
-0.0005644024349749088,
0.072062648832798,
-0.01540369912981987,
-0.0016483301296830177,
-0.02217499166727066,
-0.021823231130838394,
-0.02400144375860691,
0.003700227476656437,
-0.0009660902433097363,
0.016558069735765457,
0.02917681820690632,
0.012184572406113148,
-0.029272783547639847,
-0.020814312621951103,
-0.009539876133203506,
-0.027323629707098007,
0.0017253663390874863,
0.012790142558515072,
-0.0044890814460814,
0.021230168640613556,
0.009599775075912476,
-0.007589465938508511,
-0.04065462201833725,
0.002537498250603676,
0.0012571127153933048,
0.019399110227823257,
-0.01233318354934454,
0.03785856068134308,
-0.010013740509748459,
-0.011829758994281292,
0.007321812212467194,
0.006053335033357143,
0.0046664015389978886,
-0.004341054242104292,
-0.013933525420725346,
0.02426041103899479,
0.018685385584831238,
0.0378163680434227,
0.017991729080677032,
0.0009653508896008134,
0.005653479136526585,
-0.010883910581469536,
-0.017180366441607475,
-0.008058878593146801,
0.010499969124794006,
-0.011174147017300129,
-0.025760985910892487,
0.02104037255048752,
-0.005214250180870295,
0.0018225056119263172,
-0.0045506712049245834,
-0.005350641906261444,
-0.0029122603591531515,
0.013160068541765213,
0.005025269463658333,
-0.002966596744954586,
0.016398068517446518,
0.011015566065907478,
-0.005932308733463287,
0.022001465782523155,
-0.03297121822834015,
-0.013148668222129345,
-0.006096950266510248,
0.010278509929776192,
-0.007629352621734142,
0.008041555061936378,
-0.009795693680644035,
-0.013193828985095024,
-0.003708428703248501,
0.015874113887548447,
-0.011543133296072483,
0.028172113001346588,
-0.010678745806217194,
0.004908537492156029,
-0.0021048877388238907,
-0.0165084395557642,
0.00352181913331151,
0.02875821478664875,
0.030232643708586693,
0.02670571580529213,
0.01342394482344389,
-0.0032141213305294514,
-0.004284518770873547,
0.014826170168817043,
-0.005047795828431845,
-0.009690459817647934,
0.01771213486790657,
-0.0032935747876763344,
-0.07437178492546082,
-0.0022045420482754707,
-0.006616286467760801,
-0.004573247395455837,
0.017648272216320038,
0.01448790356516838,
-0.019485853612422943,
-0.02830136939883232,
0.02687191404402256,
0.001723176334053278,
0.00824424996972084,
0.003592020832002163,
-0.016574064269661903,
-0.010216524824500084,
0.011871537193655968,
0.0180850550532341,
-0.02462189644575119,
-0.007398512680083513,
-0.02453489601612091,
-0.004140795674175024,
-0.003915616776794195,
0.004994913004338741,
-0.016619496047496796,
0.0012860139831900597,
0.0015227784169837832,
-0.08085225522518158,
0.002060435013845563,
-0.007101794704794884,
-0.0035530822351574898,
0.004490987863391638,
0.016878489404916763,
0.007689949125051498,
-0.016906552016735077,
-0.0026630577631294727,
-0.015732208266854286,
0.0006533227860927582,
-0.010262485593557358,
-0.005278795957565308,
-0.011958054266870022,
0.03432959318161011,
-0.005818788893520832,
0.015784308314323425,
0.017930801957845688,
-0.0037752194330096245,
0.03406684845685959,
0.0024139394517987967,
0.0021154002752155066,
-0.01122223399579525,
-0.004200765863060951,
-0.003999261185526848,
-0.02439621463418007,
0.002121151424944401,
0.017604701220989227,
-0.004721746779978275,
-0.004091693554073572,
0.007040997035801411,
-0.013062866404652596,
-0.023165103048086166,
0.003537578508257866,
0.0018220143392682076,
-0.01209200918674469,
0.01437124889343977,
-0.00014152529183775187,
0.01553517859429121,
-0.011929779313504696,
-0.006978007964789867,
0.014078600332140923,
0.005265246145427227,
0.013850368559360504,
-0.013272596523165703,
-0.02227305993437767,
0.006068102084100246,
-0.00414385786280036,
0.01912803016602993,
0.005417940206825733,
0.0014099238906055689,
0.0042985049076378345,
0.007275944575667381,
0.0038283932954072952,
-0.0050374181009829044,
0.01141631230711937,
-0.0025841626338660717,
-0.017411889508366585,
0.012964705936610699,
0.006065837107598782,
-0.005400164984166622,
0.002500450238585472,
-0.0005123995360918343,
0.07104003429412842,
0.016948578879237175,
0.03131018206477165,
-0.021571338176727295,
0.003451752010732889,
0.004270806908607483,
-0.013236967846751213,
-0.009485740214586258,
-0.015309590846300125,
-0.026187468320131302,
0.018993739038705826,
-0.004033696837723255,
0.006262939888983965,
0.006247729528695345,
0.0062805162742733955,
0.01676396280527115,
0.021997077390551567,
-0.0024179585743695498,
-0.015451441518962383,
-0.004714570939540863,
0.0011644558981060982,
-0.014424243941903114,
-0.019120655953884125,
0.01129846926778555,
0.017138807103037834,
-0.011033754795789719,
-0.050809700042009354,
-0.020428776741027832,
-0.021278850734233856,
0.011957397684454918,
-0.01867099665105343,
0.023292575031518936,
-0.004788121674209833,
-0.023813700303435326,
0.021043946966528893,
0.006658108439296484,
-0.005120187997817993,
0.010375280864536762,
-0.006859758868813515,
0.012335752137005329,
-0.044079024344682693,
0.008781026117503643,
-0.008890094235539436,
0.013169369660317898,
0.008967509493231773,
-0.015517749823629856,
-0.010695476084947586,
0.01750403270125389,
0.015230557881295681,
0.00609511137008667,
-0.0005756095051765442,
0.000834569800645113,
-0.005240275990217924,
-0.0007109418511390686,
0.024566322565078735,
-0.012950917705893517,
-0.01882580853998661,
0.013196462765336037,
-0.03997096046805382,
-0.010681325569748878,
0.00523384939879179,
-0.014746055006980896,
0.020638136193156242,
-0.022140610963106155,
0.022069213911890984,
-0.02280299738049507,
0.0009760884568095207,
-0.009847266599535942,
-0.006612352095544338,
0.011868856847286224,
-0.010594407096505165,
-0.009454998187720776,
0.002821944421157241,
-0.009013731963932514,
0.026975557208061218,
0.015595585107803345,
0.023653054609894753,
0.01633884198963642,
0.01336837187409401,
-0.005890598054975271,
-0.001740200212225318,
0.034050144255161285,
0.023394949734210968,
0.04565984755754471,
-0.003591143526136875,
0.029838114976882935,
0.026106026023626328,
0.005356329493224621,
0.0004530935548245907,
0.006161364261060953,
-0.00405429070815444,
0.008356384001672268,
0.002758371876552701,
0.022125057876110077,
0.00926659069955349,
0.03366335481405258,
0.0374998115003109,
0.008724192157387733,
0.00641252938657999,
-0.0033331061713397503,
-0.0011604644823819399,
0.004953899420797825,
-0.0193523820489645,
-0.04083897918462753,
-0.0033290735445916653,
-0.00919752474874258,
0.024714138358831406,
-0.012146983295679092,
0.013952686451375484,
-0.012576572597026825,
0.006000209599733353,
0.0011730159167200327,
0.010711226612329483,
0.0030193484853953123,
0.0009288786677643657,
0.020494740456342697,
0.010597540996968746,
-0.0022804709151387215,
0.013271801173686981,
-0.011190745048224926,
-0.010304082185029984,
0.0017735265428200364,
0.02090303972363472,
0.026813291013240814,
0.005762171000242233,
0.007236064411699772,
-0.013985028490424156,
-0.004406849853694439,
-0.005141580011695623,
0.01668626070022583,
0.011696914210915565,
-0.006806090474128723,
-0.01642102189362049,
0.005189686082303524,
-0.027049625292420387,
-0.01874014176428318,
-0.017657000571489334,
-0.00856194831430912,
0.0012320817913860083,
-0.0008631148375570774,
0.01988009735941887,
0.003841421566903591,
0.003556742100045085,
0.019636180251836777,
0.008565666154026985,
-0.0059440224431455135,
-0.009122813120484352,
0.0019908789545297623,
0.010429066605865955,
0.018778886646032333,
0.00009038811549544334,
0.0038978352677077055,
0.015483035705983639,
-0.004555051214993,
-0.008782852441072464,
0.021816272288560867,
0.0033466932363808155,
-0.011788778007030487,
0.012958534061908722,
-0.01785741187632084,
0.012629221193492413,
0.011037437245249748,
-0.007499781437218189,
0.0075276317074894905,
-0.007259588688611984,
0.0046585919335484505,
-0.007964594289660454,
-0.010945519432425499,
0.01811021938920021,
-0.01985490880906582,
0.0038670613430440426,
0.002736134687438607,
-0.0013368511572480202,
-0.00921551138162613,
-0.02818678319454193,
-0.015368258580565453,
-0.028113996610045433,
0.0007077872287482023,
-0.006905154325067997,
-0.012472993694245815,
0.016555296257138252,
0.001462295651435852,
-0.016590585932135582,
-0.008672690950334072,
-0.01344296894967556,
-0.0021579440217465162,
-0.003055757377296686,
-0.02275240793824196,
0.028798453509807587,
-0.019150111824274063,
0.01086624525487423,
0.005571430549025536,
-0.0009787051239982247,
0.0020152023062109947,
-0.025251498445868492,
-0.013697298243641853,
0.0010860632173717022,
0.021914590150117874,
-0.0007292586378753185,
0.019451037049293518,
0.009430507197976112,
-0.014023980125784874
] | [
0.6942548155784607,
0.21421335637569427,
-0.2027854472398758,
0.23492111265659332,
0.12041745334863663,
0.16167505085468292,
-0.10021679103374481,
-0.10848891735076904,
0.010766339488327503,
-0.6374056935310364,
0.44514140486717224,
0.3067798912525177,
0.005127362906932831,
0.4202437102794647,
0.029403669759631157,
0.8133487105369568,
0.17874884605407715,
0.40046048164367676,
-0.03967941924929619,
-0.10963891446590424,
-0.3852151930332184,
-0.17053017020225525,
0.3678891360759735,
-0.008214674890041351,
-0.06793529540300369,
0.0481819286942482,
0.47966909408569336,
0.28821298480033875,
0.1622827798128128,
-0.22625206410884857,
-0.09080227464437485,
0.45851555466651917,
-0.3203847110271454,
-0.14652831852436066,
-0.25888004899024963,
-0.2542532682418823,
-0.10051406174898148,
0.002999894553795457,
0.2821148931980133,
-0.30188247561454773,
-0.4911171793937683,
0.4209049642086029,
-0.21963877975940704,
0.36468201875686646,
0.07606284320354462,
-0.42063817381858826,
-1.599616289138794,
0.431322306394577,
-0.3480227291584015,
-0.11933980137109756,
0.5185051560401917,
0.10036633908748627,
-0.075388602912426,
0.48608070611953735,
-0.1522110551595688,
0.34826773405075073,
-0.49654796719551086,
-0.27417007088661194,
0.30517810583114624,
-0.8239922523498535,
0.024840272963047028,
0.1893893927335739,
-0.07514481991529465,
0.026466015726327896,
0.0161692276597023,
0.3794092833995819,
0.007197954226285219,
-0.1015419289469719,
-0.2735815644264221,
-0.34724804759025574,
-0.017566727474331856,
-0.5540714263916016,
-0.2769162654876709,
0.4130551517009735,
0.41478976607322693,
-0.07562518864870071,
-0.01495799794793129,
-0.4701104462146759,
0.09768389165401459,
0.10448683053255081,
-0.2634446322917938,
-0.2829129099845886,
0.11194860190153122,
0.06492236256599426,
0.7467305660247803,
0.3692604899406433,
-0.273299902677536,
0.4291856586933136,
-0.3785293698310852,
0.08116913586854935,
-0.3921658992767334,
-0.1596096158027649,
0.338255912065506,
0.3798410892486572,
0.29745545983314514,
0.2965954542160034,
0.44537439942359924,
-0.02494952827692032,
0.13016903400421143,
0.23108580708503723,
-0.6743471622467041,
0.03844550997018814,
-0.018889574334025383,
0.002795834792777896,
-0.48369231820106506,
-0.12691007554531097,
-0.22889815270900726,
-0.3498217761516571,
-0.5251415967941284,
0.2449989765882492,
0.07181446254253387,
0.15995004773139954,
-0.21996837854385376,
-0.20216572284698486,
-0.04217147454619408,
-0.07401558756828308,
-0.031826917082071304,
-0.6338357925415039,
-0.2437666952610016,
0.528100848197937,
-0.34710606932640076,
1.0866379737854004,
-0.27401208877563477,
0.04079511761665344,
0.051230307668447495,
0.007875596173107624,
0.28182849287986755,
0.2918151021003723,
-0.11637192219495773,
0.7353427410125732,
0.3363427519798279,
0.5503314137458801,
-0.48199865221977234,
0.4321967363357544,
-0.26684656739234924,
0.004035737831145525,
0.11807426810264587,
0.5991970300674438,
0.19604040682315826,
-0.4185773432254791,
-0.7302031517028809,
-0.5644549131393433,
-0.23755137622356415,
-0.007346099242568016,
0.04485830292105675,
-0.5005425214767456,
-0.22108760476112366,
0.06903530657291412,
-0.18531383574008942,
-0.3641199469566345,
0.3166450262069702,
-0.28072360157966614,
-0.46866685152053833,
0.14842703938484192,
0.09481734782457352,
0.7488335371017456,
0.04443446546792984,
-0.05469151586294174,
-0.35245612263679504,
0.5536632537841797,
0.12407974153757095,
0.06180701032280922,
-0.44138893485069275,
-0.3200823664665222,
0.26236724853515625,
-0.08539195358753204,
0.026886645704507828,
0.4462282657623291,
-0.05627099424600601,
-0.17324605584144592,
-0.3794349431991577,
-0.4577023386955261,
-0.026400208473205566,
-0.7608337998390198,
0.0010673548094928265,
0.2351796180009842,
0.4908609092235565,
0.16035009920597076,
0.16342921555042267,
0.14584983885288239,
-0.4378634989261627,
-0.16292527318000793,
-0.2535146176815033,
-0.6395142674446106,
0.06846606731414795,
-0.21670375764369965,
0.43367037177085876,
-0.19571299850940704,
-0.17237865924835205,
-0.13467548787593842,
-0.5244227051734924,
-0.45799916982650757,
0.6722869277000427,
-0.6946559548377991,
1.608260989189148,
-0.5620886087417603,
-0.2604468762874603,
1.2192310094833374,
0.19635899364948273,
-0.186280757188797,
-0.10038840770721436,
0.3062615394592285,
0.17020712792873383,
-0.6757148504257202,
-0.7098277807235718,
0.0837058275938034,
0.4039667844772339,
-0.4002275764942169,
-0.019646748900413513,
0.36100882291793823,
0.6783672571182251,
-0.19807124137878418,
-0.15802903473377228,
-0.3362348675727844,
0.1463916003704071,
-0.18186995387077332,
-0.018991321325302124,
0.2597678303718567,
-0.040993377566337585,
-0.1518552005290985,
0.4323686957359314,
-0.5531485080718994,
0.6367648243904114,
0.5623354315757751,
-0.10510136932134628,
0.5713952779769897,
0.47922563552856445,
0.2676157057285309,
1.034332036972046,
-0.43890631198883057,
0.49795690178871155,
-0.37661367654800415,
0.1854993849992752,
-0.9523023366928101,
-0.4174802601337433,
0.15079602599143982,
0.11486009508371353,
0.1471254676580429,
-0.04541464522480965,
0.3547568917274475,
0.17957061529159546,
0.6643916368484497,
-0.9941761493682861,
-0.046036116778850555,
-0.3712168335914612,
-0.7154393196105957,
-0.6334267854690552,
0.06504320353269577,
-0.7296850085258484,
-0.4332428276538849,
0.20560131967067719,
0.3478755056858063,
0.3621519207954407,
-0.5822479128837585,
0.12412979453802109,
0.010654345154762268,
-0.2588377296924591,
-0.2558884024620056,
0.6238011717796326,
-0.18074332177639008,
0.045127060264348984,
0.4189060628414154,
0.11469260603189468,
0.1614750325679779,
0.23124660551548004,
-0.3122977614402771,
-0.5869027376174927,
-0.6763119697570801,
0.4945342540740967,
0.7865346670150757,
0.8388708233833313,
-0.02354290522634983,
-0.4692050814628601,
0.10214236378669739,
0.15371641516685486,
-0.4045117199420929,
-0.021281223744153976,
0.7433957457542419,
-0.32458561658859253,
-0.37009090185165405,
-0.32770833373069763,
-0.12115777283906937,
0.8423073887825012,
-0.1975816935300827,
-0.6003599166870117,
-0.3842536211013794,
0.1266128122806549,
-0.009463980793952942,
-0.49671483039855957,
0.174220472574234,
0.06001267582178116,
0.33560580015182495,
-0.2883005738258362,
-0.035449761897325516,
0.40145736932754517,
0.38211217522621155,
-0.21255294978618622,
0.02234746888279915,
0.6762650609016418,
-0.2901827096939087,
-0.315316379070282,
0.43052199482917786,
-0.06817835569381714,
-0.10377026349306107,
0.15040524303913116,
-0.0315868966281414,
-0.40662604570388794,
0.057022593915462494,
-6.026051044464111,
-0.2062796801328659,
-0.15435774624347687,
0.3350925147533417,
0.0889349952340126,
-0.030657615512609482,
0.9573150277137756,
-0.44308146834373474,
0.24935515224933624,
-0.24502621591091156,
0.4882182776927948,
0.8790305256843567,
-0.1719217598438263,
-0.315276175737381,
-0.004946115892380476,
0.10514150559902191,
0.5013354420661926,
-0.17672841250896454,
0.3256402611732483,
0.10921511799097061,
0.10096995532512665,
-0.0630674660205841,
-0.0995512455701828,
0.7438510060310364,
0.1121402457356453,
0.22660388052463531,
-1.181430459022522,
0.5382802486419678,
-0.12270385771989822,
0.24114438891410828,
0.21353451907634735,
-0.45953190326690674,
0.030793288722634315,
-0.5007575750350952,
0.22414708137512207,
-0.02846360392868519,
-0.30840444564819336,
-0.2706155776977539,
-0.10724843293428421,
-0.13740850985050201,
0.3525497019290924,
0.5574633479118347,
-0.17058096826076508,
-0.3623867630958557,
-0.05719152092933655,
-0.3783310651779175,
-0.17357361316680908,
0.3128166198730469,
0.040732402354478836,
0.9933139085769653,
0.07566100358963013,
-0.2263752967119217,
0.4123336672782898,
0.5997375249862671,
0.38982468843460083,
-0.25702473521232605,
0.23227298259735107,
0.18437296152114868,
-0.14872877299785614,
0.0765138566493988,
0.02425014041364193,
-0.4194698631763458,
-0.009074512869119644,
-0.3111729919910431,
-0.044881824404001236,
0.4382912516593933,
-0.5937939286231995,
-0.31990471482276917,
-0.38705530762672424,
0.0036071715876460075,
-0.6102348566055298,
0.4700087904930115,
0.10054807364940643,
-0.7509796023368835,
0.1753523200750351,
-0.23875509202480316,
-0.42264440655708313,
-0.011404589749872684,
-0.04261646047234535,
-0.021871499717235565,
0.07204196602106094,
-0.14455997943878174,
0.3585575819015503,
-0.21537943184375763,
0.24342095851898193,
-0.24497783184051514,
-0.049310360103845596,
-0.17200715839862823,
-0.5094274878501892,
0.14426927268505096,
0.48459938168525696,
-0.21880210936069489,
0.2928347587585449,
0.37618154287338257,
0.1390683799982071,
0.5181992053985596,
0.151502788066864,
0.3115832507610321,
0.12686197459697723,
-0.2538347542285919,
0.8260737061500549,
-0.12364468723535538,
-0.4452233910560608,
-0.6816328763961792,
0.22847887873649597,
0.04494651034474373,
-0.4123780131340027,
0.08805142343044281,
0.5474417209625244,
-0.7876630425453186,
0.03717651218175888,
0.2258397787809372,
-0.35386645793914795,
-0.16416053473949432,
0.5515003800392151,
-0.1016276553273201,
0.16968373954296112,
0.09639768302440643,
0.8585866093635559,
-0.34238460659980774,
0.7491538524627686,
0.4614356756210327,
-0.19044241309165955,
0.2649923861026764,
0.4894527494907379,
-0.3590637445449829,
0.5960529446601868,
0.30729642510414124,
-0.32117578387260437,
-0.14664363861083984,
0.1311255842447281,
0.3821071684360504,
-0.41473156213760376,
-0.001698267413303256,
0.2287118285894394,
0.03547414392232895,
-0.678674042224884,
0.08235723525285721,
0.24836619198322296,
-0.007326300721615553,
0.039095718413591385,
-0.20225957036018372,
-0.1055704727768898,
-0.04202025383710861,
0.3280133008956909,
0.3050593435764313,
-0.12301930040121078,
0.22546692192554474,
-0.2288532555103302,
-0.1233287900686264,
-0.002798641799017787,
0.044464632868766785,
-0.006975048221647739,
-0.11391502618789673,
-0.18286116421222687,
-0.0724620670080185,
0.6719892621040344,
0.09754770994186401,
0.3732570707798004,
-0.5512312054634094,
0.4130764603614807,
0.04300841689109802,
-1.1456739902496338,
0.20833954215049744,
-0.09477762877941132,
-0.4246838688850403,
0.29203805327415466,
-0.80085688829422,
-0.01302379835397005,
0.23011887073516846,
-0.46341758966445923,
-0.36069798469543457,
-0.24728326499462128,
-0.16047728061676025,
0.129084974527359,
-0.24730534851551056,
-0.4339354336261749,
0.1140543594956398,
-0.1658824235200882,
-0.11050201207399368,
0.2885207235813141,
-0.3442237675189972,
-0.15222306549549103,
0.10487867891788483,
0.8152787089347839,
0.05404001101851463,
-0.15227636694908142,
-0.26170989871025085,
-0.3674435615539551,
-0.2958502173423767,
0.018130863085389137,
0.2741473913192749,
0.6061177849769592,
0.27378585934638977,
-0.16049422323703766,
-0.184775248169899,
0.04140160232782364,
-0.14220106601715088,
0.012196505442261696,
-0.6702365875244141,
0.23744329810142517,
0.607166588306427,
-0.48265889286994934,
0.6302647590637207,
0.016554778441786766,
0.053864799439907074,
-0.09100063145160675,
0.052162282168865204,
0.05831648036837578,
-0.21370232105255127,
-0.35761797428131104,
-0.3902116119861603,
0.3120260238647461,
0.6830568313598633,
-0.3028677999973297,
-0.11883894354104996,
0.35016098618507385,
0.03963242843747139,
-0.08387840539216995,
0.5873310565948486,
0.20667549967765808,
-0.13302280008792877,
-0.3039092421531677,
-0.03235287591814995,
-0.35218197107315063,
0.43362051248550415,
0.5669717788696289,
-0.8347720503807068,
-0.45700523257255554,
0.19210705161094666,
-0.3526432514190674,
-0.4817642569541931,
0.2942568063735962,
0.020666932687163353,
-0.39841383695602417,
-0.013907349668443203,
-0.10860040038824081,
0.2175007313489914,
0.06703834980726242,
0.37222185730934143,
0.37866687774658203,
0.39201727509498596,
-0.3676805794239044,
-0.4017201364040375,
-0.021376105025410652,
0.46797090768814087,
0.4525406062602997,
-0.3440282940864563,
-0.2928052544593811,
0.2670854330062866,
0.21851152181625366,
-0.07464025169610977,
-0.029923133552074432,
0.13815800845623016,
0.5359285473823547,
-0.2290194034576416,
-0.38783329725265503,
-0.006915093865245581,
-0.027929529547691345,
0.1732245832681656,
-0.01556534506380558,
-0.07281814515590668,
-0.25953271985054016,
-0.19453805685043335,
-0.10963211208581924,
-0.16146749258041382,
-0.11551132798194885,
-0.4198383688926697,
0.24964705109596252,
-0.05321026220917702,
-0.13046029210090637,
0.211334228515625,
0.7371875047683716,
0.6531623005867004,
0.00856066308915615,
0.29939621686935425,
-0.5593569278717041,
-0.30640625953674316,
-0.2003975510597229,
0.32589802145957947,
-0.5032137036323547,
-0.8226547241210938,
0.21660658717155457,
-0.3774888515472412,
0.4230315685272217,
-0.41796010732650757,
0.13397927582263947,
-0.10829854011535645,
0.31736835837364197,
-0.19715061783790588,
-0.2874922752380371,
-0.20669454336166382,
-0.46203669905662537,
-0.5603204369544983,
-0.0007798123406246305,
0.14139842987060547,
0.2178976982831955,
0.11970998346805573,
0.02825033850967884,
-0.1838272660970688,
-0.4669913351535797,
0.6190295219421387,
0.5888772010803223,
-0.37668392062187195,
0.28730401396751404,
0.17665837705135345,
0.08722218871116638,
0.16516046226024628,
-0.13879519701004028,
0.08568882942199707,
0.5265014171600342,
-0.29206523299217224,
0.3702583312988281,
0.45145535469055176,
-0.20517069101333618,
0.16052575409412384,
-0.2945728302001953,
-0.6073518395423889,
0.23016870021820068,
0.2663702070713043,
0.3708939552307129,
0.48695191740989685,
0.2919258773326874,
-0.29876458644866943,
-0.372210830450058,
0.6880571246147156,
-0.3110332787036896,
-0.14773260056972504,
-0.3117855191230774,
0.253125935792923,
0.3439222276210785,
0.7863373756408691,
-0.23545239865779877,
0.08447099477052689,
0.2663436532020569,
0.6124969720840454,
0.4600209593772888,
-0.6511178016662598,
-0.23674839735031128,
-0.331590473651886,
0.19519728422164917,
-0.012746752239763737,
-0.19452117383480072,
-0.49623119831085205,
0.09411630779504776,
0.29614681005477905,
-0.24534335732460022,
0.034162651747465134,
0.14554643630981445,
0.40116003155708313,
0.2540624737739563,
-0.21365682780742645,
-0.3386104702949524,
0.21863864362239838,
-0.3618833124637604,
0.2177768498659134,
0.3912199139595032,
-0.6351128816604614,
-0.9231627583503723,
0.3294486403465271,
0.017177686095237732,
0.3148554861545563,
0.09726390242576599,
0.3796684741973877,
-0.11712287366390228,
0.2048170417547226,
0.5428302884101868,
-0.3861244320869446,
0.03931356221437454,
0.027873754501342773,
-0.35188135504722595,
-0.45118358731269836,
-0.10644304007291794,
0.19791491329669952,
0.6973828077316284,
-0.5009906888008118,
0.24791522324085236,
-0.16982288658618927,
-0.2011151760816574,
0.7842611074447632,
-0.5020915865898132,
-0.20312237739562988,
-0.23044928908348083,
-0.2790636122226715,
0.022221431136131287,
-0.1717287302017212,
-0.3075821101665497,
-0.029148181900382042,
0.09176211059093475,
-0.05262061208486557,
0.060309041291475296,
-0.7715179324150085,
0.08038140833377838,
0.3964713215827942,
-0.28250741958618164,
-0.05337406322360039,
-0.03278403356671333,
0.4049692153930664,
0.1181153729557991,
0.12031304091215134,
-0.09402889013290405,
0.2091764211654663,
-0.2798024117946625,
0.6919534802436829,
-0.5401287078857422,
0.400301992893219,
-0.6793086528778076,
-0.047979675233364105,
-0.43004631996154785,
0.13484954833984375,
0.8096137642860413,
0.1772020012140274,
-0.43972069025039673,
-0.1296810805797577,
-0.1892017275094986,
0.1384773701429367,
0.16670265793800354,
-0.32314807176589966,
0.04334435984492302,
-0.2963606119155884,
-0.05011158436536789,
-0.594204843044281,
0.6454474925994873,
-0.24447794258594513,
-0.08959817886352539,
-0.19412562251091003,
0.11597111821174622,
0.7992619276046753,
-0.5087142586708069,
0.3330278694629669,
-0.1552482396364212,
0.4020313620567322,
-0.7209664583206177,
0.3504577875137329,
-0.3694373369216919,
0.12271548807621002,
0.005393841303884983,
0.39629870653152466,
0.1359676569700241,
-0.18604154884815216,
0.2770040035247803,
-0.20090779662132263,
0.20078511536121368,
0.06361261010169983,
-0.04474366456270218,
0.30296072363853455,
0.07299336791038513,
-0.07754781097173691,
-0.6025522947311401,
0.4305855631828308,
-0.33315712213516235,
-0.4806700050830841,
-0.1505337506532669,
0.00948142260313034,
-0.19467677175998688,
0.08434022963047028,
-0.2204178273677826,
-0.33637383580207825,
0.12984013557434082,
-0.31165847182273865
] |
BACKGROUND: Myeloperoxidase (MPO), an important element of the microbicidal activity of neutrophils, generates hypochlorous acid (HOCl) from H(2)O(2 )and chloride, which is released into body fluids. Besides its direct microbicidal activity, HOCl can react with amino acid residues and HOCl-modified proteins can be detected in vivo. FINDINGS: This report is based on binding studies of HOCl-modified serum albumins to HIV-1 gp120 and three different neutralization assays using infectious virus. The binding studies were carried out by surface plasmon resonance spectroscopy and by standard ELISA techniques. Virus neutralization assays were carried out using HIV-1 NL4-3 virus and recombinant strains with CXCR4 and CCR5 coreceptor usage. Viral infection was monitored by a standard p24 or X-gal staining assay. Our data demonstrate that HOCl-modified mouse-, bovine- and human serum albumins all bind to the HIV-1 NL4-3 gp120 (LAV) glycoprotein in contrast to non-modified albumin. Binding of HOCl-modified albumin to gp120 correlated to the blockade of CD4 as well as that of V3 loop specific monoclonal antibody binding. In neutralization experiments, HOCl-modified serum albumins inhibited replication and syncytium formation of the X4- and R5-tropic NL4-3 isolates in a dose dependent manner. CONCLUSIONS: Our data indicate that HOCl-modified serum albumin veils the binding site for CD4 and the V3 loop on gp120. Such masking of the viral gp120/gp41 envelope complex might be a simple but promising strategy to inactivate HIV-1 and therefore prevent infection when HOCl-modified serum albumin is applied, for example, as a topical microbicide. | [
-0.001933727297000587,
0.00019305461319163442,
-0.016503268852829933,
0.009831885807216167,
0.003288682084530592,
-0.011437991634011269,
0.009285719133913517,
0.006681002676486969,
-0.014137172140181065,
-0.026007112115621567,
-0.0023391535505652428,
0.007977182045578957,
0.003880834672600031,
0.034252800047397614,
-0.020474236458539963,
-0.01826491579413414,
-0.02031128853559494,
0.0081096813082695,
0.012775305658578873,
0.018825765699148178,
-0.009155417792499065,
-0.0071386476047337055,
0.009915469214320183,
-0.027382757514715195,
0.004231145605444908,
0.0014236876741051674,
-0.021813612431287766,
0.0025542089715600014,
-0.004911349155008793,
-0.011002915911376476,
0.019475802779197693,
-0.0035414232406765223,
0.009322326630353928,
-0.015004009939730167,
0.011122760362923145,
-0.010727095417678356,
-0.003011892316862941,
0.015821337699890137,
0.008898898959159851,
-0.006453478708863258,
-0.00573258101940155,
-0.010149030946195126,
0.008101803250610828,
-0.007336823269724846,
-0.007273505441844463,
-0.0160664189606905,
0.0014430615119636059,
0.01738426461815834,
0.02036207728087902,
0.004773818887770176,
-0.00747010437771678,
-0.0025942036882042885,
-0.009351391345262527,
0.01860450580716133,
-0.00586615689098835,
0.022920288145542145,
0.017056385055184364,
-0.013581493869423866,
0.005594081711024046,
-0.00043921731412410736,
-0.004953428171575069,
0.015330549329519272,
-0.025228960439562798,
-0.010260704904794693,
0.0020480691455304623,
-0.06687384843826294,
-0.02266465686261654,
0.0028300622943788767,
-0.005765000358223915,
0.015531087294220924,
-0.00793857779353857,
0.007889153435826302,
0.04254237562417984,
-0.02231724187731743,
0.02633933164179325,
-0.01095566526055336,
0.008252091705799103,
-0.008846670389175415,
-0.01762387901544571,
0.031954631209373474,
0.012267607264220715,
0.005087513010948896,
-0.004698408301919699,
0.002704811515286565,
-0.00881890021264553,
-0.0024086972698569298,
-0.0395113006234169,
0.0011750799603760242,
0.006749576888978481,
-0.0035830731503665447,
0.011129677295684814,
0.014349645003676414,
0.00805794820189476,
-0.0027987491339445114,
-0.03411773592233658,
0.0015850621275603771,
0.0032014024909585714,
0.015194033272564411,
-0.020120883360505104,
-0.0255514457821846,
-0.028897304087877274,
-0.007018176838755608,
0.018373284488916397,
0.011714487336575985,
-0.004767543636262417,
0.007897055707871914,
-0.0026047206483781338,
0.008314589038491249,
0.02564297243952751,
0.01048487052321434,
-0.008596142753958702,
-0.01844210736453533,
-0.016560979187488556,
0.017966143786907196,
0.0268472358584404,
0.01382416021078825,
-0.010700179263949394,
0.03215513378381729,
0.014792440459132195,
0.04562040790915489,
0.04380062222480774,
0.03148765116930008,
0.007997638545930386,
0.014035016298294067,
0.0035524913109838963,
0.008863462135195732,
0.011657758615911007,
0.0115215377882123,
0.0028399303555488586,
-0.01572459563612938,
-0.007842506282031536,
0.0007632641354575753,
-0.011462599970400333,
0.006647730246186256,
0.00021562352776527405,
0.0022948039695620537,
-0.011310058645904064,
-0.010790688917040825,
0.009098544716835022,
-0.014927524141967297,
0.013936711475253105,
0.007566961459815502,
0.0006422549486160278,
0.0055801523849368095,
0.0022323504090309143,
0.003355782711878419,
-0.010135717689990997,
-0.0075217606499791145,
0.02237851358950138,
-0.011902878060936928,
0.017395369708538055,
-0.010346954688429832,
0.010632992722094059,
-0.017373550683259964,
0.04010452330112457,
0.0037853335961699486,
-0.009322058409452438,
0.013425523415207863,
-0.014310014434158802,
0.026195412501692772,
-0.005271484609693289,
-0.01711718551814556,
0.02374826744198799,
0.009002892300486565,
-0.023041632026433945,
0.030013777315616608,
0.02231922559440136,
-0.009486529976129532,
0.013520647771656513,
0.012176764197647572,
-0.009614937007427216,
-0.025813229382038116,
0.0005729689728468657,
0.004557366017252207,
-0.002490145619958639,
0.008855294436216354,
0.010601038113236427,
0.00908825732767582,
-0.0037836884148418903,
0.0659385621547699,
0.03389231115579605,
0.012381578795611858,
0.0016726236790418625,
0.013186994008719921,
0.012724845670163631,
-0.00553120905533433,
-0.012205125764012337,
-0.014836855232715607,
-0.004030508920550346,
-0.01579807698726654,
0.024709397926926613,
-0.020616384223103523,
-0.017595823854207993,
0.012622689828276634,
0.03987279161810875,
0.002521914429962635,
0.0163271501660347,
0.0232926607131958,
0.0033733434975147247,
-0.014296021312475204,
-0.018389051780104637,
-0.024729862809181213,
0.029071513563394547,
-0.002538016065955162,
-0.015523665584623814,
0.014420599676668644,
-0.017917189747095108,
-0.033987246453762054,
-0.02019611746072769,
0.027902396395802498,
0.014481151476502419,
0.0008984741289168596,
0.007075445726513863,
0.0010087968548759818,
-0.015412102453410625,
-0.0032320935279130936,
0.004380835220217705,
0.012323224917054176,
-0.026496626436710358,
-0.014713006094098091,
-0.0028167199343442917,
0.00860021822154522,
-0.007487048394978046,
-0.00951171014457941,
-0.0025627859868109226,
0.013990652747452259,
0.006819059140980244,
0.010762657970190048,
0.012235086411237717,
0.016520436853170395,
-0.00490594282746315,
0.00013624667190015316,
-0.015257621183991432,
0.027546653524041176,
-0.013097621500492096,
-0.0376959964632988,
0.012247205711901188,
-0.013391708955168724,
0.026930952444672585,
-0.017670702189207077,
0.02183333970606327,
-0.01917584054172039,
0.022287793457508087,
0.0025452873669564724,
0.009844573214650154,
-0.013617709279060364,
0.019046079367399216,
0.028458261862397194,
0.01275089755654335,
0.00564662367105484,
0.011506330221891403,
-0.017257772386074066,
0.007879024371504784,
-0.02895342744886875,
0.00760518666356802,
-0.023551689460873604,
-0.054692670702934265,
-0.004079869017004967,
0.02402801439166069,
-0.015180633403360844,
-0.006337660364806652,
0.00599090289324522,
0.00818982906639576,
-0.0024674562737345695,
0.021291028708219528,
0.011246507987380028,
0.023395376279950142,
0.004531075246632099,
-0.005572157446295023,
-0.0083308145403862,
0.012365002185106277,
-0.00751514034345746,
-0.01580580323934555,
-0.08124357461929321,
-0.013102970086038113,
-0.03174054995179176,
0.002351730363443494,
0.010277524590492249,
0.012182369828224182,
0.01447263266891241,
-0.000930920010432601,
-0.005225684959441423,
-0.014196297153830528,
0.030401377007365227,
0.012631523422896862,
-0.0024372455663979053,
-0.012232540175318718,
-0.005166216753423214,
-0.008524155244231224,
0.011866073124110699,
0.001223912462592125,
0.008002040907740593,
0.013425773940980434,
0.008899169974029064,
-0.00425875186920166,
-0.02391216531395912,
0.034462820738554,
0.01271442137658596,
-0.03889337182044983,
0.0039239502511918545,
-0.011045393534004688,
0.005017797462642193,
0.00696155522018671,
-0.018359120935201645,
0.02501385658979416,
0.023352468386292458,
-0.03409268707036972,
-0.010632113553583622,
-0.012477423995733261,
-0.017217569053173065,
0.01607232727110386,
-0.022237716242671013,
0.046060219407081604,
-0.0324559286236763,
0.002574170008301735,
0.005588688887655735,
-0.009752773679792881,
0.012406036257743835,
0.009602443315088749,
0.015850169584155083,
0.024530254304409027,
0.010745241306722164,
-0.008370727300643921,
-0.007537664845585823,
-0.0005601559532806277,
-0.009594634175300598,
0.017921753227710724,
-0.022502951323986053,
0.01978537254035473,
-0.02380777895450592,
-0.007666164077818394,
-0.01643470674753189,
-0.004152505658566952,
0.010597598738968372,
-0.024539362639188766,
-0.0048307087272405624,
0.022707875818014145,
-0.02766606956720352,
0.01135370135307312,
0.015113962814211845,
-0.011099254712462425,
-0.014467463828623295,
0.025536807253956795,
-0.009322252124547958,
-0.010679548606276512,
0.008624635636806488,
-0.007974227890372276,
-0.0005043584387749434,
-0.004533827304840088,
-0.0059636738151311874,
0.010753192007541656,
-0.020931635051965714,
-0.035208187997341156,
-0.027568479999899864,
0.00998981948941946,
-0.015445301309227943,
-0.02233991026878357,
-0.016569502651691437,
-0.009554537013173103,
0.008306147530674934,
-0.0013798796571791172,
0.01253538392484188,
-0.013943496160209179,
-0.001752363285049796,
0.030623814091086388,
0.0023031081072986126,
0.01261800155043602,
0.020970433950424194,
-0.015293298289179802,
-0.009990742430090904,
-0.011743440292775631,
0.00008534127846360207,
0.0069015780463814735,
0.0017176270484924316,
-0.005821963772177696,
-0.017199160531163216,
-0.015714026987552643,
0.00971224531531334,
0.013323763385415077,
0.004227995406836271,
0.020241539925336838,
0.0003792685456573963,
-0.0016858933959156275,
0.020242417231202126,
-0.02494477480649948,
-0.007282789796590805,
0.017139209434390068,
0.004313783720135689,
-0.004551947116851807,
0.0012708655558526516,
0.012084461748600006,
0.0722685381770134,
0.021018337458372116,
0.008981253951787949,
-0.02013254165649414,
0.008187464438378811,
-0.04239453375339508,
-0.04027417674660683,
0.007316893897950649,
0.017434844747185707,
-0.0029296227730810642,
0.011980896815657616,
0.00626169191673398,
-0.018495511263608932,
0.008016564883291721,
0.004898665472865105,
-0.006526382174342871,
-0.03481078892946243,
-0.007345260586589575,
0.005984831601381302,
0.0365324541926384,
-0.0366135835647583,
0.014328223653137684,
-0.019690729677677155,
-0.008934707380831242,
-0.010031534358859062,
-0.009644247591495514,
-0.03374231606721878,
-0.012397299520671368,
-0.03420247137546539,
0.01560400053858757,
0.006290454417467117,
0.029082927852869034,
-0.010338349267840385,
-0.0177568681538105,
0.014947330579161644,
-0.0039607626385986805,
0.052779361605644226,
-0.002620350569486618,
0.009444449096918106,
-0.004611107986420393,
-0.03758104890584946,
-0.017560845240950584,
0.003292486537247896,
0.015485282056033611,
0.008867472410202026,
-0.026941489428281784,
-0.0104383435100317,
-0.008607704192399979,
-0.0007772913668304682,
0.0065551577135920525,
0.01641031727194786,
0.0020855898037552834,
0.0012684115208685398,
-0.0025568201672285795,
-0.011188389733433723,
-0.002116231946274638,
-0.014690816402435303,
0.001094997744075954,
0.000721557647921145,
0.001868878724053502,
-0.03653880953788757,
0.00047823903150856495,
0.020131265744566917,
0.017577912658452988,
0.001962503418326378,
-0.004711062181740999,
-0.01664535328745842,
0.023916054517030716,
0.00876772589981556,
0.010424965992569923,
-0.004425046965479851,
-0.015805674716830254,
-0.015687033534049988,
-0.012273916974663734,
-0.02736935392022133,
-0.011751209385693073,
0.00904690008610487,
0.009771562181413174,
0.03285262733697891,
-0.005691270809620619,
-0.02021569013595581,
0.03591278940439224,
-0.03124035894870758,
-0.005392161197960377,
-0.0005545991007238626,
0.016375603154301643,
-0.004956151824444532,
-0.07499423623085022,
-0.007611358072608709,
-0.027066990733146667,
-0.0028012916445732117,
0.010046000592410564,
-0.012079766020178795,
-0.02181486040353775,
0.008522996678948402,
-0.002870160387828946,
-0.0028707263991236687,
-0.018207337707281113,
-0.005160080268979073,
-0.0024786123540252447,
-0.0019243592396378517,
0.013577543199062347,
-0.009306460618972778,
0.008979392237961292,
-0.011103082448244095,
-0.0242823027074337,
-0.019599702209234238,
-0.01653726026415825,
0.018807295709848404,
-0.019095588475465775,
0.005870247725397348,
-0.006725110113620758,
-0.08114129304885864,
0.009659629315137863,
0.017143569886684418,
-0.01333038229495287,
-0.020256265997886658,
0.03025190159678459,
0.002961262594908476,
0.0018490827642381191,
-0.009301341138780117,
-0.01875937357544899,
0.023631887510418892,
-0.015109051018953323,
0.004833370912820101,
-0.016302751377224922,
0.0023909439332783222,
-0.01637888140976429,
0.015355924144387245,
0.03798212856054306,
0.013272110372781754,
0.02726113051176071,
-0.017256498336791992,
0.049311116337776184,
-0.012766867876052856,
0.006666409783065319,
-0.006170105189085007,
-0.014848923310637474,
0.020266717299818993,
0.009366846643388271,
-0.00968031957745552,
-0.025606781244277954,
-0.022449981421232224,
-0.007597984746098518,
-0.012438218109309673,
-0.0035936266649514437,
-0.007882241159677505,
-0.02539992146193981,
-0.018216537311673164,
-0.008500268682837486,
-0.004091227892786264,
-0.010535802692174911,
-0.007871028035879135,
0.00024131801910698414,
0.008138203993439674,
-0.0016731091309338808,
0.004239777103066444,
-0.009076804853975773,
0.00417826185002923,
-0.0083747748285532,
0.008062537759542465,
0.005636218935251236,
0.0027843103744089603,
0.010871762409806252,
0.01046464592218399,
-0.005565608851611614,
0.01336146891117096,
0.01646297611296177,
-0.001349331927485764,
0.029552336782217026,
-0.03165997192263603,
0.006713265553116798,
-0.002848916221410036,
0.0025526881217956543,
0.0032924506813287735,
0.07117408514022827,
0.0050609176978468895,
-0.005139938555657864,
-0.021302927285432816,
-0.006302915513515472,
0.011069577187299728,
0.009382935240864754,
0.012953587807714939,
0.009288945235311985,
0.003783265594393015,
-0.014091207645833492,
-0.02514384314417839,
0.0025280178524553776,
0.0165141299366951,
-0.008148454129695892,
-0.011090712621808052,
0.0008826146367937326,
0.006124893669039011,
-0.01374812051653862,
-0.006567165721207857,
0.006420760415494442,
-0.03017447702586651,
0.00234783161431551,
0.020773882046341896,
0.001918950816616416,
-0.008788928389549255,
-0.009572792798280716,
0.01610279083251953,
0.007018386851996183,
0.026990555226802826,
-0.01005888357758522,
0.005493510980159044,
-0.0035723894834518433,
-0.0170187558978796,
-0.0037899096496403217,
0.0318274088203907,
-0.017430292442440987,
0.0059609124436974525,
-0.007351636420935392,
-0.007107796147465706,
-0.005789096467196941,
0.023088587448000908,
0.002810534555464983,
0.005858565680682659,
0.00796564295887947,
0.0004834928549826145,
-0.016881681978702545,
0.0021493902895599604,
0.024375518783926964,
-0.004811973311007023,
0.0014505828730762005,
-0.00469675287604332,
0.013502117246389389,
-0.028953801840543747,
-0.0008394499309360981,
-0.019253190606832504,
-0.029744386672973633,
0.01510827336460352,
-0.00913221389055252,
-0.029822930693626404,
0.05303660407662392,
-0.024140875786542892,
0.016604041680693626,
-0.021701985970139503,
0.04663215950131416,
0.013358267955482006,
0.017613906413316727,
-0.01840253919363022,
0.01629832200706005,
0.01411096379160881,
-0.013487468473613262,
0.001245562918484211,
0.015551802702248096,
-0.010090284049510956,
0.012560496106743813,
0.007642204407602549,
0.05782240629196167,
-0.02801055833697319,
0.021322010084986687,
0.010183379054069519,
-0.00911156740039587,
-0.0008437070064246655,
0.008258861489593983,
0.007234012708067894,
-0.011446977034211159,
0.005128589458763599,
0.01570025086402893,
-0.0012585367076098919,
-0.011308189481496811,
0.007029415108263493,
-0.0001885443925857544,
-0.00587228499352932,
0.00445214519277215,
0.01235000230371952,
0.010464057326316833,
0.03342502936720848,
0.03067660704255104,
0.010862821713089943,
0.01287491898983717,
0.004974100738763809,
-0.01775212772190571,
-0.019640736281871796,
-0.011122391559183598,
-0.01740654557943344,
-0.020020250231027603,
0.006779150106012821,
0.009383377619087696,
0.022801773622632027,
0.01888183131814003,
0.015473899431526661,
-0.016340047121047974,
0.011420398950576782,
-0.007237492129206657,
0.0007155416533350945,
-0.006359525956213474,
0.005329181905835867,
-0.010411782190203667,
0.01502392627298832,
0.007265766151249409,
-0.01133170910179615,
-0.018076684325933456,
-0.008578849956393242,
-0.015553651377558708,
-0.01859172247350216,
0.007199913263320923,
-0.01391573902219534,
-0.008558038622140884,
0.01988743245601654,
-0.009864652529358864,
0.027577083557844162,
0.022142963483929634,
-0.01404497865587473,
-0.01467612199485302,
-0.006421462632715702,
-0.0034495980944484472,
0.012821048498153687,
0.0008675029966980219,
0.019569305703043938,
0.015467006713151932,
-0.0034940610639750957,
0.011063974350690842,
-0.0036158401053398848,
-0.0035753168631345034,
-0.01723131351172924,
0.007404985837638378,
0.003285512328147888,
-0.004966527223587036,
-0.008521957322955132,
0.011997503228485584,
0.006997577380388975,
0.008511180058121681,
-0.00433625653386116,
-0.004107610322535038,
-0.008581304922699928,
-0.022496454417705536,
0.010814599692821503,
0.0037724196445196867,
-0.0031735363882035017,
-0.004523174837231636,
-0.004164217039942741,
-0.00848931260406971,
0.01192507240921259,
-0.015981025993824005,
-0.005238819867372513,
0.005748906638473272,
0.024652838706970215,
-0.029219292104244232,
0.002677279757335782,
0.021302195265889168,
0.00973846297711134,
-0.001636001281440258,
-0.009050954133272171,
0.005162875168025494,
0.01544258650392294,
-0.026281174272298813,
-0.00952435377985239,
-0.009855061769485474,
-0.011172856204211712,
0.04864761605858803,
-0.01355395931750536,
-0.022426273673772812,
0.012636851519346237,
0.01313495822250843,
-0.007812806405127048,
0.004327637609094381,
-0.01970055140554905,
-0.008393955416977406,
-0.003347967518493533,
-0.0026392987929284573,
0.021890901029109955,
-0.0023275273852050304,
0.005117965862154961,
-0.0006841536378487945,
0.008813755586743355,
-0.012400522828102112,
-0.023853164166212082,
0.006931632291525602,
-0.00710669532418251,
0.00417533703148365,
-0.0030797820072621107,
0.007462405599653721,
-0.024723101407289505
] | [
0.4110536575317383,
0.5521838665008545,
0.1617014855146408,
0.13275288045406342,
0.39295169711112976,
-0.025169365108013153,
-0.20674309134483337,
-0.29344767332077026,
-0.3118513524532318,
0.12327265739440918,
-0.024210140109062195,
0.057123661041259766,
-0.1260233074426651,
-0.25863879919052124,
0.11882071197032928,
0.7099271416664124,
0.6720187664031982,
0.799774706363678,
-0.1537843942642212,
-0.4995792508125305,
-0.023415343835949898,
-0.3144201636314392,
0.3791177272796631,
0.13083617389202118,
0.15264324843883514,
0.21741344034671783,
-0.06715758889913559,
0.36399900913238525,
0.12023530900478363,
-0.23151664435863495,
-0.2937357425689697,
0.3128077983856201,
0.3431074321269989,
-0.3843936622142792,
0.2600157856941223,
0.23473651707172394,
-0.3763120174407959,
0.03657662868499756,
-0.04538171365857124,
-0.5025576949119568,
-0.06352885812520981,
0.01973108947277069,
-0.08067254722118378,
0.4943726360797882,
-0.5013702511787415,
-0.3256208896636963,
-1.090511679649353,
0.5687450170516968,
-0.6541860699653625,
0.16682736575603485,
0.2574863135814667,
0.25606536865234375,
-0.05761877819895744,
0.11052639037370682,
0.2803005278110504,
-0.08645384758710861,
-0.8225845694541931,
-0.14352984726428986,
0.24000728130340576,
-0.6132634878158569,
0.0810956284403801,
-0.08807116746902466,
-0.2736709415912628,
-0.27464431524276733,
0.06845524907112122,
0.41257986426353455,
-0.15572139620780945,
-0.41114914417266846,
-0.5225691199302673,
0.015313854441046715,
0.6369420886039734,
-0.3596819341182709,
-0.34119662642478943,
0.06389684230089188,
-0.08995933830738068,
-0.13713201880455017,
-0.21409709751605988,
0.1571732610464096,
-0.017686937004327774,
0.29755792021751404,
0.23576273024082184,
-0.043004360049963,
0.10405147820711136,
0.2530434727668762,
0.06453590840101242,
0.5037496089935303,
-0.026895711198449135,
0.6573983430862427,
-0.25263985991477966,
-0.4526269733905792,
-0.252515971660614,
0.18494491279125214,
0.2713336646556854,
0.798495352268219,
0.25813087821006775,
0.12245152145624161,
0.0970798209309578,
-0.3662474453449249,
-0.00046191480942070484,
-0.06889750063419342,
-0.27935439348220825,
-0.3627474308013916,
-0.04643887281417847,
0.05925361439585686,
0.011658801697194576,
-0.2810623049736023,
-0.525088906288147,
-0.10879607498645782,
-0.44707855582237244,
-0.03926721587777138,
-0.25399985909461975,
0.053315937519073486,
-0.38401058316230774,
-0.5069124102592468,
0.27523165941238403,
-0.28887051343917847,
0.0032090251334011555,
0.048843927681446075,
0.19267413020133972,
0.5075879096984863,
-0.5267521739006042,
1.3100364208221436,
-0.28046542406082153,
0.18361061811447144,
0.1197415441274643,
-0.10809958726167679,
0.0064354087226092815,
0.3107960522174835,
-0.12277019023895264,
0.8355206251144409,
0.06920267641544342,
0.5546224117279053,
0.1884765475988388,
0.30919042229652405,
-0.03919575735926628,
-0.15243704617023468,
-0.161112979054451,
0.594984769821167,
0.05815494433045387,
0.10600243508815765,
-0.537326991558075,
-0.5353643298149109,
0.0016245061997324228,
0.19707231223583221,
0.043630920350551605,
-0.42553257942199707,
-0.43520548939704895,
-0.14702612161636353,
0.232655867934227,
-0.01805960014462471,
0.05124897509813309,
-0.24558763206005096,
-0.2951876223087311,
-0.22451451420783997,
0.27303072810173035,
0.7693765163421631,
0.0698651447892189,
-0.3533424437046051,
-0.2322779893875122,
0.10545152425765991,
0.35670483112335205,
0.14409895241260529,
-0.28369322419166565,
-0.42130911350250244,
0.5693101286888123,
0.09018123149871826,
0.29044753313064575,
0.4009173810482025,
0.10917840152978897,
0.2368401288986206,
-0.22193805873394012,
-0.6414645910263062,
0.04103842377662659,
-0.48569533228874207,
0.583789050579071,
-0.0452975332736969,
0.28014862537384033,
0.05256941169500351,
0.1560942381620407,
0.44750165939331055,
-0.7561718821525574,
0.3508434593677521,
-0.8028882145881653,
-0.9479495882987976,
0.2963145971298218,
0.25266191363334656,
0.8028252124786377,
0.26688072085380554,
-0.05079801380634308,
0.10567248612642288,
0.15094877779483795,
-0.26407095789909363,
0.7471681237220764,
-0.633342444896698,
1.5546479225158691,
-0.5844312310218811,
-0.4147365391254425,
0.44348350167274475,
0.35873541235923767,
-0.17506088316440582,
-0.450844943523407,
0.5106651186943054,
0.47976458072662354,
-0.9904151558876038,
-0.7350647449493408,
-0.001960585592314601,
0.6776628494262695,
-0.1977122575044632,
-0.18275229632854462,
-0.04175526648759842,
0.5740967392921448,
-0.26494717597961426,
0.1351252645254135,
-0.1557169109582901,
0.5582147240638733,
-0.3756064176559448,
-0.17244385182857513,
0.008186432532966137,
-0.227594792842865,
0.15222109854221344,
0.444545179605484,
-0.4277004897594452,
0.351309597492218,
0.8218808770179749,
-0.3707520365715027,
0.41020989418029785,
0.6971128582954407,
0.06599244475364685,
1.0327776670455933,
-0.4075707495212555,
0.668605625629425,
-0.07760033011436462,
-0.18159954249858856,
-0.41078925132751465,
-0.7210313677787781,
-0.2718328535556793,
0.032174982130527496,
0.24624985456466675,
0.4159824848175049,
0.20471100509166718,
-0.14680755138397217,
0.38148605823516846,
-0.9327396750450134,
-0.30535072088241577,
-0.024620981886982918,
-0.8091947436332703,
-0.23327915370464325,
0.1401999592781067,
-0.883148729801178,
-0.14885622262954712,
0.0372353233397007,
0.6344915628433228,
-0.0019967458210885525,
-0.5846759676933289,
0.4274645149707794,
-0.21986250579357147,
-0.20574936270713806,
-0.027943715453147888,
0.10996551066637039,
-0.2285430133342743,
-0.38649678230285645,
0.3979416787624359,
0.22294208407402039,
0.21943750977516174,
0.21957609057426453,
-0.11611412465572357,
-0.6889817714691162,
-0.3757033348083496,
0.6914965510368347,
0.6441630125045776,
0.6918838620185852,
-0.10170986503362656,
-0.6166335344314575,
0.011643558740615845,
0.4215300977230072,
-0.3615972101688385,
0.15281222760677338,
0.5685747265815735,
-0.5217483043670654,
-0.7968063354492188,
-0.05457340553402901,
0.8285394906997681,
0.5779902935028076,
-0.10885931551456451,
0.06413283199071884,
-0.14968645572662354,
-0.4302261173725128,
0.11480692028999329,
-0.2848292887210846,
-0.5730276107788086,
-0.20711873471736908,
0.07026221603155136,
0.11705850064754486,
-0.5863807797431946,
0.49145498871803284,
0.3110705316066742,
0.25494056940078735,
0.3017463982105255,
0.19675764441490173,
0.20534689724445343,
-0.16649466753005981,
0.20252110064029694,
-0.4454958438873291,
-0.16786311566829681,
0.4237801432609558,
0.18752603232860565,
-0.24751321971416473,
0.3221762478351593,
-6.053956985473633,
0.13893049955368042,
-0.10178911685943604,
0.1852661520242691,
0.0749916061758995,
-0.03913392499089241,
0.6787868142127991,
-0.018520068377256393,
0.1365342140197754,
0.14133362472057343,
-0.064549021422863,
0.21788311004638672,
0.10099781304597855,
-0.20406389236450195,
-0.13256016373634338,
0.04763813689351082,
-0.061150312423706055,
-0.20082581043243408,
0.1403956413269043,
0.14215192198753357,
-0.11234110593795776,
-0.06858263909816742,
0.028765760362148285,
0.3567667007446289,
0.2109890729188919,
0.09322603791952133,
-0.5971791744232178,
0.9579792022705078,
-0.18597552180290222,
-0.29022249579429626,
0.07280365377664566,
-0.34737715125083923,
0.11156601458787918,
-0.6686530709266663,
0.27326294779777527,
0.07292871177196503,
0.07995482534170151,
-0.08197546005249023,
-0.10747595876455307,
-0.358603835105896,
0.1477852761745453,
-0.24569572508335114,
-0.3640763759613037,
-0.22446443140506744,
0.09950577467679977,
0.060648418962955475,
-0.14604543149471283,
-0.001042851828970015,
-0.060089755803346634,
0.8239244818687439,
0.02771698124706745,
-0.14060889184474945,
0.4816632866859436,
0.47909918427467346,
0.43500685691833496,
0.24982917308807373,
0.050145216286182404,
0.44826433062553406,
-0.19561895728111267,
0.27413487434387207,
-0.2233617901802063,
-0.1834103763103485,
-0.1306188702583313,
-0.22148263454437256,
0.2198222577571869,
0.3125896751880646,
-0.5381729602813721,
0.0401044599711895,
0.42160242795944214,
-0.2013036161661148,
-0.21561288833618164,
0.3312872648239136,
-0.05266682058572769,
-0.8247438669204712,
0.026439355686306953,
-0.415880024433136,
0.4392196834087372,
-0.02390681393444538,
-0.17997540533542633,
0.04486086964607239,
-0.33637624979019165,
0.05218416079878807,
0.33299726247787476,
-0.0016047685639932752,
0.2025023251771927,
-0.095997653901577,
-0.20585298538208008,
0.04980230703949928,
-0.05099811404943466,
0.7019134163856506,
0.38338974118232727,
-0.042865436524152756,
-0.11312554776668549,
0.48074454069137573,
0.041110262274742126,
0.21420599520206451,
0.41476336121559143,
0.059695493429899216,
0.4446946978569031,
-0.02369554527103901,
0.6542924642562866,
0.0503738671541214,
-0.43770506978034973,
-1.0059950351715088,
0.20619982481002808,
-0.5060040354728699,
-0.6554920673370361,
0.122252456843853,
0.2896440029144287,
-0.7161480188369751,
0.020383303984999657,
-0.10649701207876205,
-0.05459514260292053,
-0.15726010501384735,
0.936592698097229,
0.12049204856157303,
0.04512129724025726,
-0.03318171575665474,
0.8192933797836304,
-0.2802642285823822,
0.37243586778640747,
0.7310935854911804,
-0.37030699849128723,
0.10566408932209015,
0.2637642025947571,
-0.0508236438035965,
0.44112834334373474,
0.5584330558776855,
-0.8232041001319885,
-0.020513512194156647,
-0.12295522540807724,
0.29746004939079285,
-0.3126625716686249,
0.10417871177196503,
0.5953020453453064,
-0.07030218094587326,
-0.5113547444343567,
0.1305810660123825,
0.721020519733429,
-0.3532245457172394,
0.5365460515022278,
-0.595295786857605,
-0.13280165195465088,
0.11030751466751099,
-0.025636250153183937,
0.3053221106529236,
-0.2201380580663681,
0.3523111045360565,
-0.15944185853004456,
-0.03524628281593323,
0.3435113728046417,
0.05642123147845268,
0.12573614716529846,
0.03355622664093971,
-0.054292529821395874,
-0.0988103523850441,
0.356113076210022,
0.1559581458568573,
0.41125810146331787,
-0.4805358946323395,
0.4210943579673767,
0.21824701130390167,
-1.1156213283538818,
-0.17882652580738068,
-0.23675258457660675,
-0.6122795343399048,
0.04852209612727165,
-0.40260687470436096,
-0.19741976261138916,
0.0692155584692955,
-0.2545306384563446,
-0.3838151693344116,
-0.5886950492858887,
-0.20903100073337555,
0.25570806860923767,
-0.2751897871494293,
-0.17291101813316345,
0.037648096680641174,
0.1595686376094818,
-0.048302002251148224,
0.03016291745007038,
-0.5081071257591248,
0.1927805244922638,
0.2120770364999771,
0.8762742280960083,
0.34372222423553467,
0.10639011114835739,
-0.14416496455669403,
-0.33716219663619995,
-0.5548370480537415,
0.4436284005641937,
0.32965633273124695,
0.30645668506622314,
0.15535949170589447,
0.32695305347442627,
0.3078979551792145,
0.22304782271385193,
0.37318480014801025,
-0.15730533003807068,
-0.16403783857822418,
-0.020176848396658897,
0.08215927332639694,
0.1365484595298767,
0.11868861317634583,
0.20609186589717865,
-0.21423405408859253,
-0.4505569338798523,
0.11120093613862991,
-0.44878917932510376,
-0.08647119998931885,
0.08833921700716019,
-0.5393990278244019,
-0.14857907593250275,
0.20371481776237488,
-0.4656214416027069,
0.10723401606082916,
0.6720237135887146,
-0.4744240343570709,
-0.5625073313713074,
0.338331401348114,
0.3029164671897888,
0.09655629098415375,
0.10496098548173904,
-0.20252178609371185,
-0.07993040233850479,
0.2033771127462387,
0.36036217212677,
-0.5126262307167053,
-0.24560508131980896,
0.13911868631839752,
-0.5281801223754883,
-0.26802730560302734,
-0.07498709857463837,
-0.07374075055122375,
-0.42151013016700745,
-0.02861960604786873,
-0.21989096701145172,
0.08709894865751266,
-0.295850545167923,
0.252642422914505,
0.1538005769252777,
0.39458054304122925,
-0.06754656881093979,
-0.25083163380622864,
-0.06767747551202774,
0.708396852016449,
0.15643972158432007,
-0.20553401112556458,
-0.2263832539319992,
0.011975958943367004,
0.8018965721130371,
-0.08324108272790909,
0.45073750615119934,
-0.09489750862121582,
0.6505982875823975,
-0.2240128517150879,
-0.05119208246469498,
-0.5932083129882812,
0.10241193324327469,
0.4414089322090149,
-0.1739025115966797,
0.04678909108042717,
-0.2911483347415924,
-0.22661082446575165,
0.11662223190069199,
0.19679491221904755,
-0.04535144567489624,
-0.3278129994869232,
0.7789761424064636,
-0.35184141993522644,
0.16952171921730042,
-0.1718609482049942,
0.17390353977680206,
0.8311106562614441,
-0.32473844289779663,
0.42582425475120544,
-0.5150890350341797,
-0.6444905996322632,
0.11080916225910187,
0.24070781469345093,
-0.5665169954299927,
-0.23674990236759186,
-0.26052597165107727,
-0.28847044706344604,
0.5163059830665588,
-0.3144513666629791,
-0.20804913341999054,
-0.10195279121398926,
-0.035406459122896194,
-0.010342709720134735,
-0.366754412651062,
0.1124388724565506,
-0.9874213337898254,
-0.7263393402099609,
0.40486589074134827,
0.4152350127696991,
-0.021974487230181694,
0.11625077575445175,
-0.2520926594734192,
-0.145243301987648,
-0.5271929502487183,
0.5073949694633484,
0.33421647548675537,
-0.34062516689300537,
0.03239854797720909,
0.17981642484664917,
0.11792916059494019,
-0.162641704082489,
-0.26970374584198,
-0.1155354306101799,
0.3727126121520996,
-0.17202892899513245,
-0.2851564884185791,
0.060516707599163055,
-0.33685874938964844,
-0.052526943385601044,
-0.23096314072608948,
-0.19480377435684204,
0.5092284679412842,
0.5529083013534546,
0.6028063893318176,
0.3685035705566406,
0.33509331941604614,
-0.21280837059020996,
-0.21568095684051514,
0.42074620723724365,
0.2709285616874695,
0.1312447041273117,
-0.13906477391719818,
0.32782626152038574,
0.6027072668075562,
0.5838820338249207,
-0.010567307472229004,
0.009795056656002998,
-0.26723673939704895,
0.3708871901035309,
-0.035057999193668365,
-0.41660940647125244,
-0.15985973179340363,
-0.20762145519256592,
0.2489880472421646,
0.44763046503067017,
-0.40691471099853516,
-0.40671154856681824,
0.3549951910972595,
0.20546892285346985,
-0.4918251931667328,
-0.304749071598053,
-0.11062850058078766,
0.6259735822677612,
0.04392005130648613,
-0.14327315986156464,
-0.34155184030532837,
-0.5880666971206665,
-0.6657399535179138,
0.1700703650712967,
-0.013087796978652477,
-0.24828119575977325,
-0.5563710331916809,
0.3985598087310791,
-0.26233646273612976,
0.44192302227020264,
-0.041961487382650375,
0.6764221787452698,
-0.1492885947227478,
-0.10134650766849518,
-0.315060555934906,
0.22555828094482422,
-0.1258835345506668,
-0.11087699979543686,
-0.47033143043518066,
-0.07703077048063278,
-0.2985658347606659,
0.11495796591043472,
0.16102904081344604,
-0.45807209610939026,
0.18043763935565948,
-0.0587749257683754,
-0.11740367859601974,
0.594964861869812,
0.035331834107637405,
0.0764373242855072,
-0.6320001482963562,
-0.5261993408203125,
-0.10587476938962936,
-0.15283650159835815,
0.04085863381624222,
0.26315656304359436,
0.14956969022750854,
-0.18004916608333588,
0.04548651725053787,
-0.9654427766799927,
0.08799342066049576,
0.4584668278694153,
0.11551936715841293,
-0.3548591434955597,
0.031242918223142624,
0.19878433644771576,
0.2811052203178406,
-0.3772847652435303,
-0.06368996202945709,
0.13209083676338196,
0.08794722706079483,
0.2642057538032532,
-0.3963567614555359,
0.5459426045417786,
-0.8769966959953308,
0.04368654638528824,
-0.7551367878913879,
0.22092463076114655,
0.5181301236152649,
0.5850220918655396,
-0.31515568494796753,
0.40755340456962585,
0.3843711018562317,
0.03692682832479477,
-0.022045990452170372,
-0.5132157206535339,
-0.02436586655676365,
-0.1453123688697815,
-0.15338626503944397,
-0.2587144672870636,
0.6486825346946716,
0.13063804805278778,
-0.1316184401512146,
-0.07146290689706802,
0.21793241798877716,
0.02141330949962139,
-0.3267004191875458,
0.019956067204475403,
-0.4500969648361206,
-0.03802523761987686,
-0.5567463636398315,
0.27978143095970154,
-0.2759822905063629,
0.44252142310142517,
-0.1716279238462448,
0.38268935680389404,
-0.3842184841632843,
-0.44042184948921204,
0.2988080382347107,
-0.18976545333862305,
0.07088617980480194,
-0.19460219144821167,
-0.302078515291214,
0.19838519394397736,
-0.15399381518363953,
-0.3028351068496704,
-0.472260981798172,
0.013773034326732159,
-0.0223583672195673,
-0.5394496917724609,
0.05576758086681366,
-0.2967311441898346,
-0.17778809368610382,
-0.023143650963902473,
-0.19961179792881012,
-0.24061834812164307,
-0.22756798565387726,
-0.21857383847236633
] |