text
stringlengths 174
10k
| embeddings_A
sequence | embeddings_B
sequence |
---|---|---|
Lung cancer is the leading cause of cancer related deaths accounting for more deaths than breast, colon and prostate cancers combined. The Rb-p16 regulatory pathway plays an essential role in tumor suppression in the lung epithelium. This is evidenced by the nearly universal alterations in Rb-p16 pathway components in lung cancer, and the increased incidence of pulmonary carcinomas in persons with germline Rb mutations. Interestingly, p16 loss and Rb mutations preferentially occur in phenotypically distinct lung cancer subtypes. Analysis of human tumors has identified progressive preneoplastic lesions that accumulate molecular alterations in an orderly sequence. Epigenetic p16 gene modifications represent an early event in lung cancer progression. This review summarizes the human studies that demonstrate a critical role for the Rb-p16 tumor suppressor pathway in lung carcinogenesis, and discusses how these findings in combination with genetically engineered mouse models have significantly contributed to our understanding of lung cancer pathogenesis. | [
-0.0019465119112282991,
0.013383716344833374,
-0.015049888752400875,
0.013190269470214844,
0.01699703559279442,
-0.03935408592224121,
0.011427320539951324,
0.028713339939713478,
-0.010180550627410412,
-0.030398910865187645,
-0.01414229441434145,
0.009815167635679245,
-0.005845515988767147,
0.031127002090215683,
-0.04993703216314316,
0.011079194024205208,
-0.03278128057718277,
0.015016190707683563,
0.011582840234041214,
-0.001648172503337264,
-0.0013206573203206062,
-0.016922079026699066,
0.010371124371886253,
-0.0034399377182126045,
-0.0022950146812945604,
0.005131614860147238,
-0.010820483788847923,
0.004037488717585802,
-0.00934949703514576,
0.00909070111811161,
0.01724281720817089,
-7.033813744783401e-7,
0.03380437195301056,
0.01320782769471407,
0.017473770305514336,
-0.00685278233140707,
-0.002124652499333024,
0.017174066975712776,
0.05351218953728676,
-0.005341512616723776,
0.004261432681232691,
-0.01204697322100401,
-0.002574673155322671,
0.009773354977369308,
-0.009654764086008072,
-0.02983064204454422,
-0.002026064321398735,
0.03774285316467285,
0.0120779350399971,
0.00927156675606966,
-0.011527793481945992,
0.00312045612372458,
-0.01791323348879814,
-0.020158790051937103,
-0.00743850227445364,
-0.010861034505069256,
0.01918535865843296,
-0.0013873693533241749,
-0.005884823389351368,
-0.022266067564487457,
0.023416869342327118,
-0.024615565314888954,
0.011027189902961254,
-0.007650818210095167,
-0.004513581749051809,
-0.06668420881032944,
0.026440022513270378,
-0.00017814827151596546,
-0.023258402943611145,
-0.024449646472930908,
-0.0033329904545098543,
0.010675066150724888,
-0.0017745414515957236,
-0.02186061069369316,
0.01648866757750511,
-0.0007783886976540089,
-0.006889136973768473,
0.008870539255440235,
0.0034463098272681236,
0.015594318509101868,
-0.010987082496285439,
-0.021657250821590424,
-0.007746722549200058,
0.02570391446352005,
-0.029403839260339737,
0.01689300127327442,
-0.004150413908064365,
-0.017212219536304474,
-0.011664233170449734,
-0.023576345294713974,
-0.006793512497097254,
0.023049544543027878,
-0.026970524340867996,
-0.040267884731292725,
-0.025485845282673836,
-0.026074841618537903,
-0.023541603237390518,
0.028043964877724648,
0.011015234515070915,
-0.0011385232210159302,
-0.004020906053483486,
0.00903799943625927,
0.01377872470766306,
-0.015527800656855106,
0.0018370808102190495,
0.009413514286279678,
0.0018044859170913696,
0.017275333404541016,
0.017124032601714134,
0.012538761831820011,
-0.038521572947502136,
0.027247590944170952,
0.002622406929731369,
-0.01886255294084549,
0.0030753202736377716,
0.008304757997393608,
0.010622365400195122,
0.022481592372059822,
0.019004197791218758,
0.007028094958513975,
-0.010714728385210037,
0.003327462123706937,
-0.006532106548547745,
0.03987422585487366,
0.0035355680156499147,
0.03238309547305107,
-0.01991071179509163,
0.03688913583755493,
-0.012727832421660423,
0.01659156009554863,
-0.011930599808692932,
-0.011934191919863224,
-0.033740416169166565,
0.01163414865732193,
0.004150134511291981,
-0.0014478261582553387,
-0.015108256600797176,
0.0025930788833647966,
-0.009672300890088081,
-0.011879470199346542,
0.012173180468380451,
0.012637410312891006,
0.0015696994960308075,
0.012891453690826893,
-0.012353431433439255,
0.01711288094520569,
0.019017986953258514,
0.002592605073004961,
-0.02138477936387062,
0.0065726120956242085,
0.004274738021194935,
0.03127112239599228,
-0.019193071871995926,
-0.012044498696923256,
0.025566283613443375,
-0.0025170943699777126,
-0.01416495069861412,
0.017161421477794647,
-0.006555386818945408,
-0.024814998731017113,
-0.02429354377090931,
-0.004201588220894337,
0.0049980925396084785,
0.010191982612013817,
0.04128635302186012,
-0.03670734167098999,
-0.007273751311004162,
-0.012113450095057487,
0.026253100484609604,
0.007618539966642857,
-0.007504626177251339,
0.004499439150094986,
-0.033894944936037064,
0.014804947189986706,
-0.0033963792957365513,
-0.00500960648059845,
0.0004517982015386224,
0.010705390013754368,
-0.01683301106095314,
0.06660102307796478,
-0.017570825293660164,
0.0499056912958622,
0.00810297392308712,
-0.017879724502563477,
-0.010109588503837585,
0.010701321065425873,
-0.009509681724011898,
-0.0028070579282939434,
-0.023551393300294876,
-0.0006283082766458392,
0.005888030864298344,
0.01893804967403412,
-0.04573266953229904,
0.012097172439098358,
-0.010295785963535309,
0.0027326978743076324,
0.007588545326143503,
0.008664070628583431,
-0.02025478146970272,
0.00907720997929573,
-0.004721728153526783,
-0.011150723323225975,
0.013566246256232262,
-0.03534403443336487,
-0.00282489275559783,
0.01903211884200573,
-0.007484062574803829,
-0.014556989073753357,
-0.0097251757979393,
0.025965528562664986,
0.004027604591101408,
-0.01249987818300724,
-0.015508239157497883,
0.015320034697651863,
0.023075468838214874,
0.038186926394701004,
-0.03523215278983116,
0.002565930597484112,
-0.009341041557490826,
-0.013690374791622162,
0.0004069689312018454,
0.02267434075474739,
0.03139301389455795,
-0.0035907793790102005,
0.04773491621017456,
-0.008988488465547562,
-0.0026523321866989136,
0.01223209872841835,
0.02953299880027771,
0.01423890795558691,
-0.0018918998539447784,
-0.055676914751529694,
-0.012688655406236649,
-0.021925248205661774,
0.040280140936374664,
0.013297450728714466,
0.015369461849331856,
-0.012706667184829712,
0.00247618043795228,
-0.010761325247585773,
-0.013140728697180748,
-0.004595907870680094,
-0.0025795900728553534,
0.0018493200186640024,
0.0007536187767982483,
-0.002966663334518671,
0.03961798548698425,
-0.014556664042174816,
0.020160363987088203,
-0.029647916555404663,
0.007689913269132376,
0.008759359829127789,
-0.007561760488897562,
0.019970402121543884,
0.035321012139320374,
0.008296338841319084,
-0.02606447972357273,
-0.009241917170584202,
0.023019324988126755,
-0.021643174812197685,
0.003658900037407875,
0.01003177184611559,
-0.012324265204370022,
-0.0306182112544775,
0.011107051745057106,
0.004273716360330582,
-0.0025371862575411797,
0.009173369966447353,
0.0055470275692641735,
-0.011188177391886711,
0.016457149758934975,
-0.011311154812574387,
-0.003598758950829506,
-0.08055095374584198,
-0.018986618146300316,
-0.01244205143302679,
-0.010969158262014389,
0.017690487205982208,
0.0037294267676770687,
-0.009424161165952682,
0.00003354984801262617,
-0.018380867317318916,
0.01473106350749731,
-0.030000539496541023,
0.002135570626705885,
-0.0018164871726185083,
-0.0074705686420202255,
-0.010292278602719307,
-0.019443679600954056,
0.013933101668953896,
-0.02851000800728798,
0.010691042058169842,
-0.022233787924051285,
0.031676966696977615,
0.037919409573078156,
0.010351322591304779,
0.012059919536113739,
-0.037926651537418365,
-0.01232084445655346,
-0.008653625845909119,
0.0003443458117544651,
-0.0016827760264277458,
0.003686951706185937,
-0.017001301050186157,
-0.00038578687235713005,
-0.017837760969996452,
-0.021300747990608215,
-0.009897900745272636,
-0.016046905890107155,
-0.001341451657935977,
-0.019550733268260956,
-0.015630308538675308,
0.04618775472044945,
0.0015966593055054545,
0.014570582658052444,
0.03057444468140602,
0.01840505376458168,
0.010952474549412727,
0.02437806874513626,
0.007515661418437958,
0.012170461937785149,
0.018786698579788208,
-0.018466532230377197,
-0.009861724451184273,
0.0034673067275434732,
-0.020358404144644737,
0.012604037299752235,
-0.006447251886129379,
-0.0033302558586001396,
-0.010917199775576591,
-0.018682483583688736,
-0.018244480714201927,
-0.01584153063595295,
-0.0035146926529705524,
0.00533568300306797,
0.029269659891724586,
0.025386907160282135,
0.026395419612526894,
0.013462016358971596,
0.022191381081938744,
-0.007462276611477137,
-0.011094532907009125,
0.013500595465302467,
0.001518578501418233,
-0.013194972649216652,
-0.004718892276287079,
-0.006274658255279064,
-0.011207451112568378,
-0.014013953506946564,
-0.010186695493757725,
-0.010306229814887047,
0.017010509967803955,
-0.012141339480876923,
-0.007727291435003281,
-0.022375375032424927,
0.00024837651289999485,
0.03254999965429306,
-0.021388014778494835,
-0.008311688899993896,
0.012774769216775894,
0.025524767115712166,
0.015442932024598122,
-0.02381713129580021,
0.03654344007372856,
0.017158247530460358,
-0.009864337742328644,
0.009310318157076836,
-0.0065097627229988575,
-0.04819978401064873,
-0.0016413659323006868,
0.01152126956731081,
0.03620225191116333,
0.010426240041851997,
-0.05161641538143158,
0.007067638449370861,
0.015472603030502796,
-0.005582128185778856,
-0.03391594812273979,
0.013286406174302101,
0.007360759191215038,
-0.01368783600628376,
-0.015871146693825722,
-0.0026500895619392395,
-0.02644772082567215,
0.005470747128129005,
-0.0038469855207949877,
0.03947465121746063,
0.014840368181467056,
0.02609149180352688,
0.002366722794249654,
-0.004203619435429573,
0.07145460695028305,
-0.014673531986773014,
0.005274470895528793,
-0.0061109233647584915,
0.0022231782786548138,
-0.010008781217038631,
-0.02665373496711254,
-0.0029114612843841314,
0.005502210929989815,
-0.006591895129531622,
0.011739138513803482,
-0.003960561007261276,
0.020570332184433937,
0.009690575301647186,
0.003727677743881941,
0.023691263049840927,
-0.01260497234761715,
0.02755102515220642,
-0.004435280337929726,
0.0006242385134100914,
-0.04617444425821304,
-0.04197724908590317,
-0.01638842560350895,
0.009762825444340706,
0.008794228546321392,
0.02221939153969288,
0.02296680025756359,
-0.01422747503966093,
-0.01551702618598938,
0.007616935297846794,
-0.036821912974119186,
-0.0063663930632174015,
-0.004749031737446785,
0.00549343740567565,
-0.007161042187362909,
-0.012407848611474037,
0.017431391403079033,
-0.03920353949069977,
-0.005735957995057106,
0.0026493624318391085,
-0.012058233842253685,
-0.014967876486480236,
0.012008454650640488,
0.005879126954823732,
-0.008707422763109207,
0.0024074192624539137,
-0.003647692035883665,
-0.010453754104673862,
0.015880048274993896,
0.0033987760543823242,
-0.016403114423155785,
-0.00804496742784977,
0.010149412788450718,
-0.004390186630189419,
-0.03988366201519966,
-0.013937669806182384,
0.014492648653686047,
-0.007454432547092438,
-0.011564437299966812,
-0.010685794055461884,
-0.00922851450741291,
-0.006012803874909878,
-0.010743232443928719,
-0.037508513778448105,
-0.0019502295181155205,
0.008284279145300388,
-0.02294432558119297,
-0.02434455417096615,
-0.004376058932393789,
-0.01128875371068716,
0.008789473213255405,
0.01912718079984188,
0.000040836865082383156,
-0.00062594935297966,
-0.031998053193092346,
0.03615618869662285,
-0.012303806841373444,
0.009533688426017761,
-0.0004889646079391241,
-0.030102122575044632,
-0.01476394571363926,
0.023461032658815384,
0.013381777331233025,
0.012927837669849396,
0.05536111444234848,
-0.00474039139226079,
0.008905360475182533,
-0.07377459108829498,
-0.021216213703155518,
-0.009946547448635101,
-0.004575347527861595,
-0.00955949630588293,
0.018504418432712555,
-0.015397803857922554,
-0.050746336579322815,
-0.00269716908223927,
-0.008975807577371597,
-0.036999329924583435,
0.016523342579603195,
-0.021382611244916916,
0.015925941988825798,
0.015941152349114418,
0.02198958396911621,
0.036437422037124634,
0.005312459543347359,
-0.017465271055698395,
0.026196733117103577,
0.04745492711663246,
-0.006455086637288332,
-0.012624256312847137,
-0.0008305053925141692,
0.0014121788553893566,
-0.08039511740207672,
-0.010128581896424294,
0.0014984190929681063,
-0.0018100864253938198,
0.006330712232738733,
-0.024939632043242455,
0.027667198330163956,
-0.016402896493673325,
-0.04269753396511078,
-0.01858295314013958,
-0.051506951451301575,
0.0027612773701548576,
-0.006710236892104149,
-0.00880802609026432,
-0.003281573997810483,
-0.01373303309082985,
0.02781590446829796,
-0.03680022060871124,
-0.025433890521526337,
0.008044816553592682,
0.02613300085067749,
0.0027008934412151575,
-0.010018527507781982,
-0.04031893238425255,
-0.010394180193543434,
0.029410135000944138,
-0.005395391955971718,
0.009484801441431046,
0.003897302784025669,
-0.03769933432340622,
-0.012633562088012695,
-0.026629973202943802,
-0.006771163083612919,
-0.02881203219294548,
0.007236462086439133,
-0.015149878337979317,
0.020401088520884514,
0.01219829823821783,
-0.006281848065555096,
-0.013701457530260086,
-0.007299025543034077,
0.022168809548020363,
-0.023811709135770798,
0.013477382250130177,
-0.00268434826284647,
-0.03301434963941574,
0.009733656421303749,
-0.006136714015156031,
0.017285402864217758,
-0.012948699295520782,
0.005123378708958626,
0.004860360641032457,
-0.009820417501032352,
-0.00886039063334465,
0.020263561978936195,
-0.019064467400312424,
-0.0068258801475167274,
-0.013064514845609665,
0.008600990287959576,
0.006001985166221857,
0.003199776168912649,
0.004277191124856472,
-0.023256825283169746,
0.07150328159332275,
0.007220522500574589,
0.019812997430562973,
-0.027457091957330704,
-0.007187339477241039,
0.01057380624115467,
-0.022038813680410385,
-0.010647243820130825,
-0.020534394308924675,
-0.026688113808631897,
-0.0034723221324384212,
-0.016498181968927383,
0.003982889000326395,
0.009122855961322784,
0.03326265513896942,
0.012823088094592094,
0.015590949915349483,
-0.011380832642316818,
-0.022401610389351845,
-0.01376824826002121,
0.0049300771206617355,
0.009465811774134636,
0.0001345132477581501,
0.021940134465694427,
-0.022177789360284805,
-0.013385886326432228,
-0.028981678187847137,
-0.01781366765499115,
-0.01210356317460537,
-0.010404666885733604,
0.002983695827424526,
-0.005299393553286791,
0.005414273589849472,
-0.006039733067154884,
0.021627485752105713,
0.01927557960152626,
-0.010510014370083809,
0.009349770843982697,
0.00024609710089862347,
-0.009737168438732624,
0.007294506765902042,
0.008451194502413273,
0.00011467980220913887,
-0.02518324740231037,
0.02347686141729355,
-0.011352797970175743,
0.000715174712240696,
0.002167239785194397,
-0.017406009137630463,
0.016443010419607162,
-0.007411257829517126,
0.005330735817551613,
-0.006951694376766682,
-0.005731511395424604,
0.0142380241304636,
-0.03405480086803436,
0.012917198240756989,
0.012381341308355331,
-0.008560152724385262,
-0.0048156967386603355,
0.01828927733004093,
0.0008386632543988526,
0.01127299852669239,
-0.012055517174303532,
0.011982152238488197,
0.005363342817872763,
0.023833725601434708,
-0.02030993066728115,
0.001358887180685997,
0.016156254336237907,
0.0065872445702552795,
-0.014429759234189987,
0.009301701560616493,
-0.02833382971584797,
0.02498766779899597,
-0.004291456658393145,
0.04522205889225006,
0.0005474386271089315,
0.03347501903772354,
0.015958819538354874,
-0.012308638542890549,
-0.0051217335276305676,
0.0342223197221756,
-0.026018386706709862,
-0.047798871994018555,
0.029741382226347923,
0.02257518097758293,
-0.0009441259317100048,
-0.004681261721998453,
0.010549567639827728,
0.026720978319644928,
0.006920400075614452,
0.009269122034311295,
0.01086755096912384,
0.009037851355969906,
0.033876992762088776,
0.04147596284747124,
0.005150790326297283,
0.01603398099541664,
-0.0006560520268976688,
0.028062041848897934,
-0.008498001843690872,
-0.012317202985286713,
0.009556964971125126,
-0.002433359855785966,
-0.015522056259214878,
-0.008762713521718979,
-0.037018030881881714,
-0.0030961164738982916,
0.020923767238855362,
0.007075516972690821,
0.006011159159243107,
0.00019104592502117157,
0.002484348136931658,
0.01137564703822136,
0.03966376557946205,
-0.027426227927207947,
-0.004467205610126257,
-0.006225675344467163,
-0.018709536641836166,
0.020305456593632698,
0.0057155657559633255,
-0.02763219177722931,
0.047765232622623444,
-0.032759279012680054,
0.0002702130004763603,
-0.005057568661868572,
0.019126469269394875,
-0.014497604221105576,
0.001220339210703969,
0.00501174246892333,
-0.01704820990562439,
-0.046346865594387054,
0.0033191819675266743,
0.004378562327474356,
0.023899180814623833,
-0.004616056568920612,
0.03284921497106552,
0.009147221222519875,
0.028018444776535034,
-0.006317833438515663,
-0.0267384871840477,
-0.002250700257718563,
0.014483562670648098,
0.00958232395350933,
-0.005867377854883671,
-0.006929096300154924,
0.00375298410654068,
0.005246246699243784,
-0.016332242637872696,
0.01527309324592352,
0.024335436522960663,
0.010585665702819824,
-0.009486048482358456,
-0.021094711497426033,
0.013347260653972626,
0.012503363192081451,
-0.019876880571246147,
0.009505262598395348,
-0.02011924982070923,
-0.012715938501060009,
-0.02677420899271965,
-0.01665496453642845,
-0.01597580872476101,
0.02657577209174633,
0.007666530087590218,
0.019399218261241913,
0.034111153334379196,
-0.016237135976552963,
-0.003122798865661025,
0.03674187511205673,
0.020182602107524872,
-0.006506496574729681,
0.012793073430657387,
-0.026051629334688187,
-0.003224402666091919,
-0.01340358704328537,
-0.015308801084756851,
-0.01629502698779106,
0.0071760560385882854,
-0.014327590353786945,
0.00361427990719676,
0.032454561442136765,
-0.014787937514483929,
-0.00888934824615717,
-0.02591228112578392,
-0.009423928335309029,
0.0006943074986338615,
-0.00433869706466794,
-0.03485814854502678,
-0.002542989794164896,
-0.0008380808867514133,
-0.015060964971780777,
-0.009865375235676765,
-0.013806726783514023,
-0.004752335604280233,
-0.006588186603039503,
-0.029843073338270187,
0.00622445298358798,
-0.02184445410966873,
0.038501519709825516,
-0.015307295136153698
] | [
0.3191371560096741,
0.26392146944999695,
-0.10539619624614716,
0.06411589682102203,
0.43851572275161743,
0.05506759509444237,
-0.03740766644477844,
0.003946311306208372,
-0.2726368308067322,
-0.8156331181526184,
-0.02831456996500492,
0.2105954885482788,
-0.601536750793457,
0.3484587073326111,
0.009562388062477112,
0.8111034035682678,
0.2654096186161041,
0.5408178567886353,
-0.16191358864307404,
-0.6543809175491333,
-0.30031806230545044,
-0.18083970248699188,
0.9381003379821777,
0.3445563018321991,
0.07744047045707703,
-0.40710723400115967,
0.3305630385875702,
-0.08295836299657822,
0.004514794796705246,
0.1988331377506256,
-0.20080488920211792,
0.5751143097877502,
0.3490871489048004,
0.05580201372504234,
0.03896474838256836,
-0.05616769194602966,
-0.08136463910341263,
-0.21217072010040283,
-0.03769475221633911,
0.2311071753501892,
-0.2931758463382721,
0.09419944137334824,
-0.026491055265069008,
0.5187199711799622,
0.14405839145183563,
-0.34400466084480286,
-1.2692426443099976,
0.9401682615280151,
0.4943428933620453,
0.19223903119564056,
0.3221566379070282,
0.046597931534051895,
0.1050892248749733,
0.5076262950897217,
0.3276616334915161,
0.1956392377614975,
-0.36560705304145813,
0.057057395577430725,
0.06763873249292374,
-0.2865775227546692,
0.24934343993663788,
-0.16309726238250732,
-0.6043381094932556,
0.025998320430517197,
0.36897894740104675,
0.23176749050617218,
0.13712207973003387,
-0.40274205803871155,
-0.8402276039123535,
-0.36731866002082825,
-0.06855972856283188,
-0.6341450810432434,
0.036052484065294266,
0.3560538589954376,
-0.3064984083175659,
0.24109326303005219,
-0.13612598180770874,
-0.20149824023246765,
0.20034447312355042,
0.06273780763149261,
0.41347917914390564,
-0.06363753229379654,
0.059282924979925156,
0.5606051087379456,
0.294836163520813,
-0.0773819163441658,
-0.2451123297214508,
0.6887392997741699,
-0.03438195586204529,
-0.19582891464233398,
0.4609012007713318,
-0.3232131004333496,
0.4742000997066498,
0.316690593957901,
0.2421324998140335,
0.5105265378952026,
0.6119150519371033,
0.23096679151058197,
-0.29538410902023315,
-0.45844796299934387,
-0.4285847544670105,
-0.11946380883455276,
0.38128364086151123,
-0.3956570327281952,
-0.36748790740966797,
-0.5611156821250916,
0.0270968247205019,
-0.2702854871749878,
-0.057671256363391876,
0.1088397204875946,
-0.5441898107528687,
-0.05148201808333397,
-0.3388155400753021,
-0.4947630763053894,
-0.16733990609645844,
0.5363584160804749,
0.19696226716041565,
-0.7719279527664185,
0.40136727690696716,
-0.1502094864845276,
0.0696105808019638,
0.9895503520965576,
-0.47825977206230164,
0.26603397727012634,
-0.4641452431678772,
-0.09108541160821915,
0.7079177498817444,
0.22255674004554749,
-0.10425448417663574,
0.1694546788930893,
0.08691456913948059,
0.9097525477409363,
-0.3092370629310608,
0.004663938656449318,
0.19333988428115845,
-0.14325684309005737,
0.05081143230199814,
-0.11692007631063461,
0.6874257922172546,
-0.33364760875701904,
-0.5671340227127075,
-1.085375189781189,
-0.2603415548801422,
0.06310880929231644,
-0.3817543685436249,
-0.2738102674484253,
-0.13061611354351044,
-0.25673526525497437,
-0.06788868457078934,
-0.7111151218414307,
0.26055076718330383,
-0.08256730437278748,
-0.7807652950286865,
0.08177737891674042,
-0.1323712319135666,
-0.012473280541598797,
0.6922693848609924,
-0.784882664680481,
0.10474099218845367,
0.08369145542383194,
0.2916417717933655,
-0.5914819836616516,
0.022841518744826317,
0.037314917892217636,
0.37063905596733093,
-0.019576771184802055,
0.2798607349395752,
0.348081111907959,
-0.3228796422481537,
-0.22772064805030823,
-0.50627601146698,
-0.18429085612297058,
0.32078391313552856,
-0.8253107666969299,
0.24497206509113312,
-0.09831342101097107,
0.3995159864425659,
0.2331739366054535,
0.23991140723228455,
0.23543278872966766,
-0.5681065320968628,
0.1468069702386856,
0.07380816340446472,
0.050248876214027405,
0.7100002765655518,
-0.018540158867836,
0.5746145844459534,
0.4183904826641083,
0.44125691056251526,
0.08182940632104874,
-0.39935535192489624,
-0.7916045784950256,
0.7414238452911377,
-0.16104547679424286,
1.156569004058838,
-0.2490667998790741,
0.028088053688406944,
0.5942419767379761,
0.302127867937088,
-0.3138180077075958,
-0.4082864820957184,
0.21791236102581024,
0.8433388471603394,
-0.41545310616493225,
-0.8122239112854004,
-0.14387501776218414,
0.016496751457452774,
-0.3087705075740814,
-0.07946007698774338,
-0.2315749078989029,
0.8114345073699951,
-0.604695737361908,
-0.11708034574985504,
-0.07774973660707474,
0.42600202560424805,
-0.28791648149490356,
-0.5535126328468323,
0.10206735879182816,
-0.4346820116043091,
-0.19286134839057922,
0.13070207834243774,
-0.6622610688209534,
0.5779771208763123,
0.5723584890365601,
0.3677799701690674,
0.83152174949646,
0.03576698526740074,
-0.2190542221069336,
0.6250235438346863,
-0.10730152577161789,
0.3043902516365051,
-0.45966488122940063,
-0.10172733664512634,
-0.2983495593070984,
-0.23267722129821777,
0.33780980110168457,
-0.09244411438703537,
-0.22758886218070984,
0.24659126996994019,
-0.15849488973617554,
0.09857439994812012,
0.42855146527290344,
-1.0208972692489624,
-0.03091306984424591,
-0.0039810799062252045,
-0.25868678092956543,
-0.6850261688232422,
-0.004338935948908329,
-0.6334071159362793,
-0.18105939030647278,
0.2463686168193817,
0.48791566491127014,
-0.029516559094190598,
-0.7009133100509644,
0.027965081855654716,
0.1560676544904709,
0.033857379108667374,
-0.10580287128686905,
0.2521461844444275,
-0.918268620967865,
-0.21942155063152313,
0.03934812545776367,
0.2835540771484375,
0.05916647985577583,
-0.20963303744792938,
-0.22609582543373108,
-0.8842705488204956,
-0.45141345262527466,
0.7435629367828369,
0.41624125838279724,
0.7856136560440063,
0.23856061697006226,
-0.669771134853363,
0.057034559547901154,
0.016581255942583084,
-0.4020828902721405,
-0.2558029592037201,
0.5963290333747864,
-0.6678639650344849,
-0.17898428440093994,
0.04327129200100899,
0.37198302149772644,
0.8022962212562561,
-0.5056813359260559,
-0.6592015027999878,
0.7312935590744019,
0.4606323838233948,
-0.13452483713626862,
-0.19999493658542633,
0.03766752406954765,
-0.5553158521652222,
0.20110023021697998,
-0.09606847912073135,
0.1423981487751007,
0.4553765058517456,
0.22187094390392303,
-0.04960983619093895,
0.45714470744132996,
0.5617735385894775,
-0.3895511329174042,
-0.03794267401099205,
0.19564327597618103,
-0.4886535406112671,
-0.5360215902328491,
-0.2332201451063156,
0.09126085788011551,
-0.6868679523468018,
0.4809826612472534,
-5.721470832824707,
-0.021676786243915558,
0.07744546234607697,
-0.231230691075325,
-0.2866998314857483,
-0.1748705953359604,
0.3106822073459625,
-0.06303003430366516,
0.1698155254125595,
-0.0030001653358340263,
0.5362673997879028,
0.5833340287208557,
0.4728547930717468,
-0.11541900783777237,
-0.5825718641281128,
0.08832215517759323,
0.13189829885959625,
-0.45363351702690125,
0.28754961490631104,
-0.2099476307630539,
0.5580982565879822,
-0.294348806142807,
-0.22212174534797668,
0.33810803294181824,
0.2657322287559509,
0.47648385167121887,
-0.7361371517181396,
0.20787037909030914,
-0.4059474766254425,
-0.6610035300254822,
0.16021451354026794,
-0.44166088104248047,
0.020116690546274185,
0.2102886289358139,
0.3712694048881531,
-0.2253178060054779,
-0.25819578766822815,
-0.22179894149303436,
0.15131472051143646,
-0.07971376925706863,
0.4997311532497406,
-0.26885539293289185,
-0.7335156202316284,
-0.08491237461566925,
0.2129945158958435,
-0.2783336937427521,
-0.12229713052511215,
0.1796804964542389,
-0.33695000410079956,
0.6408143639564514,
0.422795832157135,
-0.2680715322494507,
0.12613502144813538,
0.287469744682312,
0.7138398885726929,
0.48335036635398865,
-0.4078410565853119,
-0.020999277010560036,
-0.5406680703163147,
-0.08755820244550705,
-0.6031334400177002,
-0.04623763635754585,
-0.12324213981628418,
-0.5344189405441284,
-0.3230537474155426,
0.44698071479797363,
-0.5505380630493164,
-0.8138938546180725,
0.355401873588562,
-0.1808851659297943,
0.13473409414291382,
0.857379674911499,
0.5608692169189453,
-0.49090367555618286,
-0.1275755912065506,
-0.373242050409317,
0.3705531358718872,
0.29913628101348877,
-0.3013594448566437,
-0.6298582553863525,
-0.5646021962165833,
0.050724416971206665,
0.09086865186691284,
-0.32180941104888916,
0.13809986412525177,
-0.4258172810077667,
-0.3567184507846832,
0.09976445883512497,
0.008600054308772087,
0.4328120946884155,
0.692743182182312,
-0.7254284620285034,
0.12389819324016571,
0.38180482387542725,
0.35401949286460876,
0.5196688175201416,
0.3944084644317627,
0.39785391092300415,
0.6475738883018494,
0.3183886706829071,
1.00826895236969,
0.13018770515918732,
-0.8993398547172546,
-0.9099628925323486,
-0.3784225583076477,
0.22424949705600739,
-0.3076184093952179,
0.24530182778835297,
0.8729028701782227,
-0.7774814963340759,
0.5998104810714722,
0.083198182284832,
-0.20632748305797577,
-0.719509482383728,
0.6881706118583679,
-0.6426277160644531,
-0.5277398824691772,
0.27765029668807983,
0.7457360625267029,
-0.39081647992134094,
0.5773812532424927,
0.22588704526424408,
-0.4734092950820923,
0.2682689130306244,
0.48074811697006226,
0.2907527983188629,
0.26554301381111145,
0.7146754860877991,
-1.0601565837860107,
0.0861099511384964,
0.3158321976661682,
0.32913416624069214,
-0.1523570716381073,
0.10236597061157227,
0.1752893477678299,
-0.05009940266609192,
-0.4331233501434326,
0.4236362874507904,
0.28431829810142517,
-0.14953479170799255,
0.15743616223335266,
0.1889560967683792,
-0.167082741856575,
-0.2591313123703003,
0.43870779871940613,
0.07873737066984177,
-0.6329344511032104,
-0.12502866983413696,
0.03886043280363083,
-0.2346007525920868,
0.3419897258281708,
-0.004375055432319641,
0.12981127202510834,
-0.2600305676460266,
-0.34616246819496155,
0.1835615336894989,
0.39365166425704956,
0.010160078294575214,
0.23568612337112427,
-0.5696190595626831,
0.342695415019989,
-0.00909467414021492,
-0.7114852070808411,
-0.03182336315512657,
-0.4520200192928314,
-0.30214738845825195,
-0.11667833477258682,
-0.3775924742221832,
-0.26115360856056213,
0.44139641523361206,
-0.2814047932624817,
-0.32411399483680725,
0.03237563744187355,
-0.0003747938899323344,
0.3173842132091522,
-0.42796531319618225,
-0.46105054020881653,
0.0648932009935379,
-0.0029196643736213446,
0.14383094012737274,
0.09152185171842575,
-0.5213543772697449,
-0.41223347187042236,
0.7283486723899841,
0.18140651285648346,
0.5827817916870117,
0.07776807248592377,
-0.05389316752552986,
-0.5019575953483582,
-0.2540760636329651,
-0.24669422209262848,
-0.08060713112354279,
0.14208869636058807,
-0.2015615850687027,
0.03613114356994629,
-0.24111808836460114,
-0.25968989729881287,
0.12112601101398468,
-0.1212954968214035,
-0.49157848954200745,
0.1868777871131897,
0.721861720085144,
-0.3400847613811493,
0.03711828589439392,
0.366398423910141,
-0.1036875918507576,
-0.12039007246494293,
0.07091181725263596,
-0.10288642346858978,
0.08020946383476257,
-0.23062294721603394,
-0.4925979971885681,
0.39568859338760376,
0.46708956360816956,
-0.5759843587875366,
0.04378843680024147,
0.43982452154159546,
-0.20611560344696045,
-0.04280751943588257,
0.2581801116466522,
0.5278865694999695,
0.010224414058029652,
-0.22403307259082794,
-0.08467786014080048,
-0.38418909907341003,
0.33800458908081055,
0.05517109856009483,
-1.0232977867126465,
0.25759246945381165,
-0.29813873767852783,
-0.5456362366676331,
-0.1606520116329193,
-0.03488759323954582,
-0.5122614502906799,
0.3035445213317871,
-0.7221171259880066,
0.0533592589199543,
0.24362100660800934,
-0.19102616608142853,
0.30860063433647156,
0.49426698684692383,
0.5692054629325867,
-0.37550508975982666,
-0.4766516387462616,
-0.13438989222049713,
0.21749848127365112,
0.4182298481464386,
-0.7060236930847168,
-0.7956883907318115,
0.02162788435816765,
0.7093244791030884,
-0.21063733100891113,
-0.16692283749580383,
0.18136654794216156,
0.8999971151351929,
0.05333263427019119,
0.14951954782009125,
-0.2836425006389618,
-0.39702752232551575,
0.45674043893814087,
-0.049002569168806076,
-0.03264448419213295,
-0.025098757818341255,
0.1599927842617035,
0.7693570852279663,
0.1459382176399231,
-0.1529531329870224,
-0.38124021887779236,
0.2616114616394043,
-0.3246508240699768,
0.4197830855846405,
0.40105679631233215,
0.6050640344619751,
-0.016958611086010933,
0.1398012787103653,
0.5651788115501404,
-0.2886032462120056,
0.3105146884918213,
-0.05949006229639053,
0.4315330684185028,
-0.34388428926467896,
-0.6884501576423645,
0.5652384161949158,
-0.5346930027008057,
0.36289897561073303,
-0.6945441365242004,
0.336034893989563,
-0.12738902866840363,
0.01612665504217148,
-0.3698846995830536,
-0.06689628213644028,
-0.5772278904914856,
-0.9313331246376038,
-0.441788911819458,
0.15301181375980377,
-0.0142601877450943,
0.15282514691352844,
0.4244385361671448,
0.24899734556674957,
-0.14889098703861237,
-0.7342841029167175,
0.37206029891967773,
0.3382236957550049,
-0.39539965987205505,
0.5784737467765808,
0.15360933542251587,
0.32767799496650696,
0.11700299382209778,
-0.3708445727825165,
-0.15029042959213257,
0.4775473177433014,
-0.2456427812576294,
0.20482398569583893,
0.6145150065422058,
-0.23297157883644104,
0.2772293984889984,
-0.629237174987793,
0.18672895431518555,
0.6132884621620178,
-0.003276857314631343,
0.08343286067247391,
0.4044519364833832,
0.6185086965560913,
0.14005151391029358,
-0.4055912494659424,
0.23059064149856567,
0.0498976930975914,
0.41122204065322876,
0.35169491171836853,
0.15181012451648712,
0.4708862602710724,
0.47610145807266235,
-0.1335083246231079,
0.8394020199775696,
0.3366582989692688,
0.13442054390907288,
-0.017676103860139847,
-1.0907708406448364,
-0.5367828607559204,
-0.2035285085439682,
0.7986531853675842,
0.19776707887649536,
0.2110118716955185,
0.10504110157489777,
0.25304484367370605,
0.5112437009811401,
-0.42003411054611206,
0.0951809212565422,
-0.07914837449789047,
-0.2994912564754486,
0.24280324578285217,
-0.5334423184394836,
-0.8562726974487305,
0.19712163507938385,
-0.5685307383537292,
0.19300910830497742,
0.5448946952819824,
-0.6227028965950012,
-0.10196919739246368,
0.32896193861961365,
-0.304520845413208,
-0.08016639202833176,
-0.3238809108734131,
0.5634218454360962,
0.13522958755493164,
0.12381626665592194,
0.21192488074302673,
-0.1780666559934616,
0.22196009755134583,
-0.4208430051803589,
0.11040277779102325,
0.058232638984918594,
-0.0787409171462059,
-0.06283967941999435,
0.25600460171699524,
-0.2604827284812927,
0.12173540145158768,
-0.167924702167511,
0.12664714455604553,
0.03965580090880394,
-0.3910422921180725,
0.11141097545623779,
-0.14452992379665375,
-0.4564550220966339,
-0.32939308881759644,
-0.44342130422592163,
-0.30660280585289,
-0.3144301772117615,
0.8066751956939697,
-0.15348674356937408,
0.16315442323684692,
-0.41429403424263,
0.06946997344493866,
0.19553150236606598,
0.29059362411499023,
-0.734451413154602,
0.020742448046803474,
0.18456152081489563,
0.03907979652285576,
0.5884080529212952,
0.3861018717288971,
0.11438746750354767,
-0.07980096340179443,
0.6229698061943054,
-1.0040311813354492,
0.3849146366119385,
-0.2176133394241333,
-0.07973071932792664,
-0.5946600437164307,
0.33595404028892517,
0.7861768007278442,
0.4770488440990448,
-0.2658439874649048,
0.5252333879470825,
0.22065122425556183,
0.2084181308746338,
0.4425164759159088,
-0.5259705185890198,
-0.3432404100894928,
-0.5757431983947754,
-0.16538573801517487,
-0.3182368278503418,
0.4899686574935913,
-0.4398804008960724,
-0.09138862043619156,
-0.12345720827579498,
0.1865721493959427,
0.3638589084148407,
-0.03272966668009758,
0.5040854215621948,
-0.6500962972640991,
0.5145019292831421,
-0.9047843813896179,
0.17552100121974945,
-0.4648606479167938,
0.16400791704654694,
0.17016340792179108,
-0.3138153553009033,
-0.31365975737571716,
-0.5077207684516907,
0.12691223621368408,
-0.45305079221725464,
-0.1362592875957489,
0.12311318516731262,
0.3908742666244507,
-0.008736026473343372,
0.23348462581634521,
-0.4549514949321747,
-0.458900511264801,
0.6908711194992065,
0.11110581457614899,
-0.1291249841451645,
0.2636469900608063,
0.3503521978855133,
0.11635797470808029,
-0.10342440009117126,
-0.11892948299646378,
-0.31396642327308655,
0.024066658690571785,
0.2703583538532257
] |
BACKGROUND Screening for cervical cancer based on testing for human papillomavirus (HPV) increases the sensitivity of detection of high-grade (grade 2 or 3) cervical intraepithelial neoplasia, but whether this gain represents overdiagnosis or protection against future high-grade cervical epithelial neoplasia or cervical cancer is unknown. METHODS In a population-based screening program in Sweden, 12,527 women 32 to 38 years of age were randomly assigned at a 1:1 ratio to have an HPV test plus a Papanicolaou (Pap) test (intervention group) or a Pap test alone (control group). Women with a positive HPV test and a normal Pap test result were offered a second HPV test at least 1 year later, and those who were found to be persistently infected with the same high-risk type of HPV were then offered colposcopy with cervical biopsy. A similar number of double-blinded Pap smears and colposcopies with biopsy were performed in randomly selected women in the control group. Comprehensive registry data were used to follow the women for a mean of 4.1 years. The relative rates of grade 2 or 3 cervical intraepithelial neoplasia or cancer detected at enrollment and at subsequent screening examinations were calculated. RESULTS At enrollment, the proportion of women in the intervention group who were found to have lesions of grade 2 or 3 cervical intraepithelial neoplasia or cancer was 51% greater (95% confidence interval [CI], 13 to 102) than the proportion of women in the control group who were found to have such lesions. At subsequent screening examinations, the proportion of women in the intervention group who were found to have grade 2 or 3 lesions or cancer was 42% less (95% CI, 4 to 64) and the proportion with grade 3 lesions or cancer was 47% less (95% CI, 2 to 71) than the proportions of control women who were found to have such lesions. Women with persistent HPV infection remained at high risk for grade 2 or 3 lesions or cancer after referral for colposcopy. CONCLUSIONS The addition of an HPV test to the Pap test to screen women in their mid-30s for cervical cancer reduces the incidence of grade 2 or 3 cervical intraepithelial neoplasia or cancer detected by subsequent screening examinations. (ClinicalTrials.gov number, NCT00479375 [ClinicalTrials.gov].). | [
-0.023559339344501495,
0.013204950839281082,
-0.013296261429786682,
0.024341899901628494,
0.006649435963481665,
0.022020339965820312,
0.00960616860538721,
-0.021641425788402557,
-0.009738972410559654,
-0.014136211946606636,
-0.0001781410537660122,
0.009063596837222576,
-0.007020335644483566,
0.014710059389472008,
0.020882651209831238,
-0.01115250214934349,
-0.01877017691731453,
0.01795942522585392,
0.0035662748850882053,
0.003315899521112442,
0.026001282036304474,
-0.027565723285079002,
0.009295687079429626,
-0.019490152597427368,
0.00774341868236661,
0.014667815528810024,
0.007133074104785919,
-0.033254753798246384,
0.022826220840215683,
-0.021987084299325943,
-0.019011996686458588,
-0.008820475079119205,
0.009816541336476803,
-0.015756022185087204,
0.0003303935518488288,
0.0026683565229177475,
0.000981205957941711,
0.028345242142677307,
-0.0035703210160136223,
-0.003267883090302348,
-0.01673228293657303,
-0.01209854893386364,
0.007032301742583513,
-0.013339439406991005,
-0.008894799277186394,
0.002135124523192644,
-0.013558854348957539,
0.003586926031857729,
0.004388759844005108,
0.00949156191200018,
-0.0034956284798681736,
0.013368316926062107,
-0.016243353486061096,
-0.002479853108525276,
-0.006963458843529224,
0.022886697202920914,
0.017491688951849937,
0.02814869023859501,
-0.02313421107828617,
-0.03101988136768341,
-0.009580417536199093,
-0.03699283301830292,
0.026580048725008965,
0.011693907901644707,
-0.024555563926696777,
-0.06676201522350311,
0.028256025165319443,
-0.028622031211853027,
0.001838567666709423,
0.001463583204895258,
0.0022328216582536697,
0.004667418077588081,
0.01758158765733242,
0.021021757274866104,
0.004892162047326565,
0.012498859316110611,
0.0013516326434910297,
0.00808410532772541,
-0.007790748029947281,
-0.0189046747982502,
0.03553188219666481,
0.021231461316347122,
0.03405066207051277,
0.012849352322518826,
-0.01605808362364769,
0.004529022611677647,
-0.01718239113688469,
0.005362764932215214,
0.007351926527917385,
0.010855326429009438,
0.009071744978427887,
0.015571089461445808,
-0.04987247288227081,
-0.022106701508164406,
-0.04410621523857117,
-0.01949157938361168,
-0.00522236805409193,
-0.027768202126026154,
-0.00849198829382658,
-0.012698996812105179,
-0.00019225303549319506,
0.021320264786481857,
0.011538231745362282,
0.0010907291434705257,
-0.012114131823182106,
0.013009471818804741,
-0.0024263758677989244,
0.0007760385051369667,
0.013939879834651947,
0.005924150347709656,
-0.0015847180038690567,
0.0179028008133173,
-0.01079520396888256,
-0.0029647850897163153,
0.015425487421452999,
-0.014310183003544807,
0.015479286201298237,
0.02025969699025154,
-0.0034606787376105785,
0.028637316077947617,
-0.04445571452379227,
-0.00856652483344078,
0.006226882804185152,
-0.008208826184272766,
0.0026835936587303877,
0.005888325162231922,
0.013818156905472279,
-0.003617025213316083,
0.029063589870929718,
-0.021514590829610825,
-0.007410903926938772,
0.00463117565959692,
0.004502925556153059,
-0.020423104986548424,
-0.007099609822034836,
-0.0013584051048383117,
0.0016631202306598425,
-0.003102554939687252,
-0.010509325191378593,
-0.016144201159477234,
0.012482702732086182,
0.010063569992780685,
-0.0010590176098048687,
0.010137642733752728,
-0.016255423426628113,
-0.00980423390865326,
-0.014832220040261745,
-0.006690943613648415,
-0.017123451456427574,
-0.004067109897732735,
-0.021164122968912125,
0.008113499730825424,
-0.01201435923576355,
-0.02418264001607895,
0.02794599160552025,
-0.012612440623342991,
-0.0347864031791687,
0.011752025224268436,
0.003949217963963747,
-0.012003995478153229,
-0.003352415282279253,
-0.004017771687358618,
0.027189437299966812,
0.010817928239703178,
-0.010860126465559006,
0.010589534416794777,
-0.007627767510712147,
0.00012300966773182154,
-0.0018859049305319786,
0.00482564140111208,
0.0021635955199599266,
0.002976229414343834,
-0.006537366192787886,
0.011119766160845757,
0.024508049711585045,
-0.010220633819699287,
0.04439449682831764,
0.005921029951423407,
-0.007544403430074453,
0.06599286198616028,
0.0004627050366252661,
-0.004819437861442566,
-0.026567503809928894,
0.01284041628241539,
0.01810067892074585,
-0.026407111436128616,
-0.010363440960645676,
-0.0014338656328618526,
0.015840400010347366,
-0.0019297539256513119,
-0.005224128253757954,
-0.007294929586350918,
-0.02050173282623291,
0.02401881292462349,
-0.029945967718958855,
0.003443606896325946,
0.005017164163291454,
0.01569920778274536,
0.010253539308905602,
0.016471054404973984,
0.010233812034130096,
-0.010820449329912663,
0.015856698155403137,
0.01470201276242733,
-0.04398780316114426,
0.011232580989599228,
0.012001057155430317,
0.013599813915789127,
0.013571837916970253,
-0.0016078318003565073,
0.01472061313688755,
-0.026284003630280495,
0.006986317224800587,
-0.000992089044302702,
0.0035293083637952805,
0.010975688695907593,
0.0067092422395944595,
0.007648879662156105,
-0.020272698253393173,
-0.01745501533150673,
0.00017679331358522177,
0.01844431459903717,
0.0217940341681242,
0.018318966031074524,
0.001956245396286249,
-0.04325361177325249,
0.02279578521847725,
0.0044436827301979065,
0.0038698455318808556,
0.014126017689704895,
-0.0175166092813015,
-0.016718078404664993,
-0.01041469257324934,
0.03360109031200409,
0.016120579093694687,
-0.0004250833299010992,
0.012078594416379929,
-0.003042665310204029,
0.009626025334000587,
-0.01805282011628151,
-0.008159596472978592,
-0.0028895940631628036,
0.013506215997040272,
-0.022938575595617294,
-0.015471060760319233,
0.03357117995619774,
0.028468016535043716,
-0.0057980092242360115,
-0.007882637903094292,
0.003436153056100011,
0.007429672870784998,
0.012327654287219048,
0.014458118006587029,
-0.011928023770451546,
-0.0011923722922801971,
-0.02045501209795475,
-0.018764272332191467,
0.0219055637717247,
0.025752052664756775,
-0.017520463094115257,
0.01850314438343048,
0.008624959737062454,
0.003760579274967313,
-0.01897037774324417,
-0.024248871952295303,
0.007817288860678673,
-0.0016876475419849157,
-0.00980297289788723,
0.004275055602192879,
0.011442456394433975,
0.008845023810863495,
-0.011815112084150314,
-0.0063994755037128925,
-0.08119787275791168,
-0.00486365333199501,
0.015328376553952694,
-0.032964520156383514,
0.006833079736679792,
-0.01393297128379345,
0.008629808202385902,
0.025387108325958252,
-0.0031988988630473614,
0.002293991856276989,
0.029213685542345047,
0.020533639937639236,
-0.008127572946250439,
0.004520446062088013,
-0.012924838811159134,
0.002314621349796653,
0.005767337046563625,
0.004328622482717037,
-0.05588999763131142,
-0.02664564922451973,
0.007569412235170603,
0.0001134965568780899,
0.016058534383773804,
0.0038019856438040733,
0.016208600252866745,
0.021649010479450226,
-0.003907660488039255,
0.011875798925757408,
-0.015512713231146336,
0.005749034695327282,
-0.0002432558685541153,
-0.019270027056336403,
0.01810581423342228,
0.012739754281938076,
-0.01563715562224388,
-0.018495110794901848,
-0.016919247806072235,
0.01435243058949709,
-0.007927757687866688,
0.013973968103528023,
-0.014315234497189522,
0.002308949828147888,
0.017452307045459747,
-0.0004944151150994003,
0.006328048184514046,
0.006443273276090622,
0.016153031960129738,
0.0527728796005249,
0.022732004523277283,
-0.008181784301996231,
0.024157410487532616,
-0.011060715653002262,
-0.019634639844298363,
0.011432575061917305,
-0.010514099150896072,
0.007394334767013788,
-0.036218542605638504,
0.004751306492835283,
-0.011525092646479607,
-0.00546770915389061,
0.03229120001196861,
-0.019912779331207275,
0.02733500674366951,
0.028344759717583656,
-0.009379612281918526,
0.01311067771166563,
-0.0020320084877312183,
0.014619939029216766,
-0.013565593399107456,
0.027664516121149063,
0.014242986217141151,
-0.018055442720651627,
-0.02505190297961235,
-0.00016163429245352745,
0.009187358431518078,
-0.005994877777993679,
-0.017195969820022583,
-0.0070358021184802055,
-0.02070625312626362,
0.025146450847387314,
-0.01253595482558012,
0.0017667601350694895,
-0.002441074699163437,
0.006273174192756414,
0.0028722528368234634,
0.06453801691532135,
0.010428947396576405,
0.006305674556642771,
0.014914479106664658,
-0.007926937192678452,
0.01403983123600483,
-0.0002042548730969429,
0.021022312343120575,
0.008365641348063946,
0.03306231647729874,
-0.020224863663315773,
0.012051813304424286,
0.04040989279747009,
0.028816431760787964,
0.007383805233985186,
0.0208054818212986,
-0.013058258220553398,
0.0017362444195896387,
-0.012690644711256027,
-0.02722480520606041,
0.008901161141693592,
-0.0027596005238592625,
-0.01793091371655464,
-0.023563120514154434,
-0.004473634529858828,
0.003401363268494606,
-0.005268539302051067,
-0.008551642298698425,
-0.0010186494328081608,
0.0024207185488194227,
0.026374051347374916,
0.009492864832282066,
-0.01003846526145935,
0.07209348678588867,
-0.010656366124749184,
0.008550886064767838,
-0.022979125380516052,
-0.0021994253620505333,
-0.007535361684858799,
0.020414361730217934,
0.006392850540578365,
-0.012895522639155388,
0.008206051774322987,
0.012694602832198143,
0.005189206916838884,
-0.0017307177186012268,
-0.006142917089164257,
0.010313594713807106,
0.015588970854878426,
0.021294549107551575,
0.011572236195206642,
0.01560322754085064,
-0.0037356375250965357,
-0.017452776432037354,
0.015629194676876068,
-0.016750238835811615,
-0.03547557070851326,
0.02253001369535923,
-0.03551521897315979,
0.009286807850003242,
-0.013131072744727135,
-0.02220837026834488,
0.004645657259970903,
-0.028021864593029022,
0.0044694337993860245,
-0.004379181191325188,
-0.006880630739033222,
0.00563848577439785,
0.014079080894589424,
0.004716867581009865,
0.005842833314090967,
0.0015581492334604263,
-0.019757186993956566,
0.0019146264530718327,
-0.010766573250293732,
0.012911655008792877,
0.011144815944135189,
-0.019877959042787552,
0.01734141632914543,
-0.03385550156235695,
-0.010801928117871284,
0.007047224789857864,
-0.008934498764574528,
-0.0031363926827907562,
-0.002227871445938945,
0.019015023484826088,
-0.0020188107155263424,
-0.02968934178352356,
0.030643761157989502,
0.0016664369031786919,
-0.017264211550354958,
-0.011307311244308949,
0.015279026702046394,
0.0038131580222398043,
-0.030565135180950165,
-0.006360831670463085,
-0.006555953063070774,
-0.003163604298606515,
-0.015509014949202538,
-0.0071744597516953945,
-0.00032468303106725216,
0.020721834152936935,
-0.03673079237341881,
-0.014457357116043568,
0.012222555465996265,
-0.01659977436065674,
-0.026814743876457214,
-0.03552445396780968,
0.012896100990474224,
-0.01955249533057213,
-0.0007699788548052311,
-0.018063984811306,
-0.022943992167711258,
-0.007115394342690706,
-0.014681585133075714,
-0.009376373142004013,
-0.01668163575232029,
0.018193800002336502,
-0.006500133778899908,
-0.025429729372262955,
-0.0752200335264206,
-0.016621645539999008,
0.00382135808467865,
-0.012812321074306965,
-0.0026153321377933025,
0.027209296822547913,
-0.015554401092231274,
0.00350333284586668,
-0.030015382915735245,
-0.006319714244455099,
0.017362236976623535,
0.0017888410948216915,
0.017312821000814438,
-0.0195561945438385,
0.016124125570058823,
0.0007730179931968451,
-0.01569245755672455,
-0.000278945779427886,
0.00611047213897109,
-0.01977735199034214,
0.04427909851074219,
-0.005280171521008015,
-0.0026958202943205833,
-0.016590364277362823,
-0.010767016559839249,
-0.08107990771532059,
0.010815917514264584,
-0.020669903606176376,
-0.00664164125919342,
-0.014129485934972763,
-0.015052511356770992,
0.027664951980113983,
0.0010947630507871509,
-0.03454884886741638,
-0.015234897844493389,
-0.009102459996938705,
-0.015429527498781681,
0.013601775281131268,
0.00689229741692543,
-0.0010671811178326607,
-0.008784548379480839,
0.015187766402959824,
-0.011358565650880337,
-0.00006530899554491043,
0.0038232007063925266,
-0.031639691442251205,
0.030931759625673294,
-0.00393332215026021,
0.0015203151851892471,
-0.01015552505850792,
-0.0078049395233392715,
-0.02912614494562149,
0.016036733984947205,
0.004717049188911915,
-0.02458387240767479,
0.0024598659947514534,
-0.025561120361089706,
-0.014419221319258213,
-0.02545599825680256,
-0.014319971203804016,
-0.005854644812643528,
0.02988722175359726,
-0.013479124754667282,
-0.00845385156571865,
0.0014686838258057833,
-0.0014548241160809994,
0.02886008471250534,
-0.001260257326066494,
-0.019597060978412628,
0.01579834148287773,
-0.010872838087379932,
0.010671019554138184,
-0.008838394656777382,
0.00871786568313837,
-0.0025702249258756638,
0.0015008954796940088,
-0.0028153699822723866,
-0.0003813400398939848,
-0.004345576744526625,
0.010074586607515812,
0.0053407615050673485,
-0.01064299512654543,
0.021607056260108948,
-0.014525854960083961,
0.005384327843785286,
-0.005006955936551094,
-0.00021579302847385406,
-0.013415345922112465,
0.07109931111335754,
-0.004484452307224274,
0.02187628298997879,
-0.005804985761642456,
-0.0055194152519106865,
0.004382077604532242,
-0.006402300670742989,
-0.026599181815981865,
-0.016424061730504036,
-0.00029516546055674553,
-0.006304210051894188,
0.009957592934370041,
0.010820833966135979,
0.009890174493193626,
-0.02402113378047943,
0.0008685276843607426,
0.0050282240845263,
0.03038310445845127,
0.011814020574092865,
-0.026816977187991142,
0.026515278965234756,
0.02208564430475235,
-0.016451630741357803,
-0.029325226321816444,
0.0016408935189247131,
-0.0085170678794384,
-0.0099839698523283,
-0.01641393080353737,
-0.037602510303258896,
0.002916131168603897,
0.014456585049629211,
0.00342057878151536,
0.009226227179169655,
0.0029036442283540964,
0.013516220264136791,
-0.008575130254030228,
0.004227683413773775,
0.009683134965598583,
0.019603583961725235,
-0.008703716099262238,
0.04153591766953468,
-0.010114572942256927,
-0.004407559055835009,
-0.03878345340490341,
0.030468257144093513,
-0.035485830157995224,
0.009601469151675701,
-0.005239157937467098,
0.0014670428354293108,
0.02070416510105133,
0.006974808871746063,
0.01490904949605465,
0.004156449344009161,
-0.004495664965361357,
0.0005357419140636921,
-0.007800807245075703,
-0.007561585865914822,
0.017017800360918045,
0.03275315463542938,
0.0055694580078125,
0.02188715524971485,
-0.011624516919255257,
-0.006787318270653486,
-0.0129633080214262,
0.0047871726565063,
-0.0009264163672924042,
0.00729336915537715,
-0.013829863630235195,
-0.02469458244740963,
0.010249430313706398,
-0.03224785998463631,
0.0010122070088982582,
0.007928223349153996,
-0.004846148658543825,
-0.00006598187610507011,
0.028878800570964813,
0.018834207206964493,
0.01155068725347519,
-0.008540838956832886,
0.006304265931248665,
-0.011966779828071594,
0.011313477531075478,
-0.016591552644968033,
0.01764068379998207,
-0.005396070424467325,
-0.005802605766803026,
0.006538937799632549,
0.013586585409939289,
-0.008077617734670639,
-0.0002858416992239654,
-0.016768157482147217,
0.014268586412072182,
-0.005177608225494623,
0.011314419098198414,
0.005371874198317528,
0.03530663996934891,
-0.013067591935396194,
0.008311133831739426,
0.004080190323293209,
-0.016526665538549423,
0.020648561418056488,
-0.0018596594454720616,
-0.03619611635804176,
0.02454833872616291,
0.0018086610361933708,
-0.007320343982428312,
0.026874493807554245,
-0.032379329204559326,
-0.010984653607010841,
0.051137566566467285,
-0.006075187120586634,
-0.018591465428471565,
0.05125438794493675,
0.009584907442331314,
0.009062458761036396,
-0.016022559255361557,
0.0007496536709368229,
0.019079234451055527,
0.022540997713804245,
-0.01181490533053875,
0.0078017739579081535,
-0.009650507010519505,
-0.000019022496417164803,
0.00519467331469059,
-0.0004317587590776384,
-0.002850760705769062,
-0.010985620319843292,
-0.0005823420360684395,
-0.008414242416620255,
-0.002965365769341588,
0.007576745003461838,
-0.022563576698303223,
0.004624237306416035,
0.02055990695953369,
-0.016018368303775787,
-0.03197193145751953,
0.004255135077983141,
-0.009266795590519905,
0.0005196472629904747,
-0.009261265397071838,
-0.022720661014318466,
-0.017860155552625656,
0.009329631924629211,
-0.01205894723534584,
0.011243602260947227,
-0.01924910955131054,
-0.032866138964891434,
0.007433964405208826,
0.006558046210557222,
0.024301744997501373,
0.016583111137151718,
0.02138226479291916,
-0.0016228542663156986,
-0.006678023375570774,
-0.0012426176108419895,
0.004915936850011349,
0.008888661861419678,
-0.01554633118212223,
0.009981362149119377,
0.00549242552369833,
0.0012952378019690514,
0.004054377321153879,
0.003928735852241516,
0.014335956424474716,
-0.0014472372131422162,
0.023661969229578972,
-0.019260970875620842,
0.011250970885157585,
-0.04161885380744934,
0.0022578490898013115,
0.018337050452828407,
-0.005772650241851807,
-0.00871400348842144,
0.022224489599466324,
-0.008253417909145355,
0.004251027479767799,
-0.011579508893191814,
-0.0008593845413997769,
-0.006367352791130543,
0.010637638159096241,
0.029475845396518707,
0.0050956555642187595,
0.01067165844142437,
-0.013097217306494713,
-0.019155442714691162,
0.007889841683208942,
-0.013137773610651493,
-0.005625090096145868,
0.004700314253568649,
0.026699084788560867,
-0.03540379926562309,
0.017459699884057045,
0.000299062579870224,
-0.0034870649687945843,
0.0007007010281085968,
0.028051117435097694,
0.006442292593419552,
-0.027834206819534302,
-0.01043473556637764,
0.01120501197874546,
0.026961589232087135,
-0.024314412847161293
] | [
0.6315858364105225,
-0.09005390107631683,
-0.12095271795988083,
0.09348784387111664,
0.2827213704586029,
0.5745362043380737,
0.05313408374786377,
-0.324847936630249,
-0.5608157515525818,
-0.17521601915359497,
0.2979047894477844,
0.1534455120563507,
0.09527646750211716,
-0.05498313158750534,
-0.3589082658290863,
0.43712660670280457,
0.7317898273468018,
0.6063106656074524,
-0.15370222926139832,
-0.6327495574951172,
-0.5483816862106323,
-0.45140424370765686,
0.49314212799072266,
0.27723076939582825,
-0.07652241736650467,
0.19219322502613068,
0.5596774220466614,
0.11530453711748123,
0.173270121216774,
-0.269008070230484,
-0.10028091073036194,
0.4768669009208679,
0.26568523049354553,
-0.1720406711101532,
0.27394405007362366,
0.03469279408454895,
0.20445238053798676,
-0.09050936996936798,
-0.022228587418794632,
-0.15511448681354523,
-0.4869445860385895,
-0.37442782521247864,
-0.2998877763748169,
0.3070223033428192,
0.03621949627995491,
-0.33616164326667786,
-0.915422797203064,
0.6360592246055603,
-0.04752679169178009,
0.09456305205821991,
0.294364333152771,
0.09106997400522232,
0.1338382065296173,
0.27296948432922363,
0.06343734264373779,
0.13510985672473907,
-0.27266204357147217,
0.09017275273799896,
0.03903141990303993,
-0.22903797030448914,
0.22102318704128265,
0.17360518872737885,
0.2182464748620987,
0.38020947575569153,
0.3647341728210449,
0.17960259318351746,
0.08328165113925934,
0.2885942757129669,
-0.2537508010864258,
-0.3226574659347534,
-0.17079590260982513,
-0.35698044300079346,
-0.08571749180555344,
-0.19446323812007904,
-0.12375438213348389,
0.36149919033050537,
-0.2271920144557953,
-0.18291537463665009,
0.6277352571487427,
-0.149607852101326,
0.06562495976686478,
-0.0853400006890297,
0.07028684765100479,
-0.08096327632665634,
0.6406955718994141,
0.3805373013019562,
0.029823385179042816,
0.26674705743789673,
0.6228460073471069,
-0.2612000107765198,
-0.14340555667877197,
-0.10395403206348419,
0.6386258602142334,
0.5821169018745422,
0.11047607660293579,
0.3914657533168793,
-0.38291463255882263,
0.15080514550209045,
0.34156450629234314,
-0.1082136258482933,
-0.3851839303970337,
0.07157602161169052,
-0.08899608999490738,
0.03347332775592804,
-0.8611993789672852,
-0.42384102940559387,
0.1984177678823471,
0.045492276549339294,
-0.7067436575889587,
0.1364918202161789,
-0.6217277646064758,
0.001514750998467207,
-0.23544186353683472,
-0.23745836317539215,
-0.6553574800491333,
0.16663073003292084,
0.18000508844852448,
-0.3546111583709717,
0.028310436755418777,
-0.13272413611412048,
-0.8680026531219482,
0.5745908617973328,
-0.3643525242805481,
0.45634904503822327,
0.09296441078186035,
0.5346032381057739,
0.8532657623291016,
0.783941388130188,
-0.2250106781721115,
0.17494867742061615,
0.12297648191452026,
0.5503212809562683,
-0.015162208117544651,
0.2216397374868393,
-0.08820749074220657,
-0.5850827693939209,
-0.24959927797317505,
0.3299556374549866,
0.5570266246795654,
0.0380498431622982,
-0.6108673214912415,
-0.5305477976799011,
-0.10343588143587112,
-0.10170300304889679,
-0.029718203470110893,
-0.626041829586029,
0.162873774766922,
0.04659801721572876,
-0.22488076984882355,
-0.18216148018836975,
0.22102782130241394,
0.1648595631122589,
-0.22921337187290192,
-0.6077926754951477,
-0.0016901250928640366,
0.012761780060827732,
0.13492263853549957,
-0.27383437752723694,
-0.059350479394197464,
-0.30036333203315735,
0.36340421438217163,
0.40055227279663086,
-0.48115965723991394,
0.35188403725624084,
0.6901175379753113,
0.016008449718356133,
0.1481085568666458,
-0.0044798823073506355,
0.08445800840854645,
0.5310690999031067,
-0.44343268871307373,
0.08940201252698898,
-0.4607095718383789,
-0.32239994406700134,
-0.17202791571617126,
0.298005074262619,
0.2613045275211334,
0.03195188194513321,
0.22543781995773315,
-0.19154271483421326,
-0.5218304991722107,
0.32397106289863586,
-0.07987421751022339,
-0.5767863988876343,
0.07086797803640366,
0.062266793102025986,
0.16276143491268158,
0.2178758680820465,
0.014079309068620205,
0.043948136270046234,
-0.05927678197622299,
-0.6345134973526001,
0.6200507283210754,
-0.23809675872325897,
1.1473411321640015,
-0.5880366563796997,
0.07886607944965363,
1.501402497291565,
0.09353514760732651,
-0.2186364382505417,
-0.14653818309307098,
0.22165288031101227,
0.7481126189231873,
0.07891075313091278,
-1.1770062446594238,
-0.07312676310539246,
-0.04260396212339401,
-0.2776486277580261,
-0.2731552720069885,
-0.1619609147310257,
0.02376864291727543,
0.15122756361961365,
-0.4553526043891907,
-0.2797553241252899,
-0.0918525755405426,
0.48312142491340637,
-0.38023844361305237,
0.25379660725593567,
0.5560422539710999,
-0.15189602971076965,
0.2745245099067688,
-0.8380041122436523,
0.39997991919517517,
0.00843014195561409,
-0.05368969216942787,
0.4913327097892761,
0.30560988187789917,
-0.14501699805259705,
0.3308817446231842,
-0.5632295608520508,
0.2912798821926117,
0.0959082692861557,
0.2898341715335846,
-0.15665476024150848,
-0.24519264698028564,
0.15676316618919373,
-0.42014190554618835,
-0.5288432836532593,
-0.10435202717781067,
0.18400295078754425,
-0.07200531661510468,
0.4451630711555481,
-0.3644171357154846,
-0.08796598017215729,
0.17223449051380157,
-0.1328520029783249,
-0.677888035774231,
0.18773145973682404,
-0.12598927319049835,
0.3221643567085266,
-0.21006010472774506,
0.003700161585584283,
-0.1718057096004486,
-0.4642210602760315,
-0.27823567390441895,
-0.09759119898080826,
0.0015276680933311582,
-0.5132080316543579,
0.20348751544952393,
-0.9413105249404907,
0.2712329924106598,
0.291975200176239,
0.292580246925354,
0.36518871784210205,
0.4222319424152374,
-0.4052002429962158,
-0.7364335060119629,
-0.5904460549354553,
0.8649073243141174,
0.6719886660575867,
0.6672505736351013,
0.23895376920700073,
-0.5954678058624268,
-0.08385974168777466,
-0.194710373878479,
-0.6770841479301453,
0.009523077867925167,
0.8273696303367615,
-0.3803820312023163,
-0.4808078110218048,
0.025840282440185547,
0.052077293395996094,
0.6000035405158997,
-0.2210036814212799,
-0.05979610234498978,
-0.0898352786898613,
-0.041113708168268204,
-0.16314469277858734,
-0.13293921947479248,
-0.2704281210899353,
-0.1900220513343811,
0.6146106719970703,
-0.0770178809762001,
-0.1757737547159195,
0.6361414194107056,
0.25644510984420776,
-0.5043532848358154,
0.7537723779678345,
0.8622028231620789,
-0.14752912521362305,
0.1727987378835678,
-0.10860305279493332,
0.05771902576088905,
-0.09078745543956757,
-0.15921983122825623,
-0.04660849645733833,
-0.13514521718025208,
-0.16519761085510254,
-6.026543140411377,
0.25098085403442383,
-0.6165797710418701,
-0.2751542031764984,
-0.49796050786972046,
0.21706409752368927,
0.9500797390937805,
-0.06801694631576538,
0.5031552314758301,
0.353106290102005,
-0.16272422671318054,
0.8325648903846741,
0.2805238664150238,
0.3229691684246063,
0.009580671787261963,
0.6298421025276184,
0.15947850048542023,
-0.3413827121257782,
0.42147111892700195,
-0.0550861731171608,
0.14590102434158325,
-0.23993819952011108,
-0.24005982279777527,
0.2989271879196167,
0.41477763652801514,
0.6900338530540466,
-0.6047156453132629,
0.24201498925685883,
-0.38746124505996704,
-0.3180675208568573,
0.18954941630363464,
-0.6737907528877258,
-0.14024598896503448,
0.24412110447883606,
-0.17553044855594635,
0.09120471775531769,
0.3417605459690094,
-0.10621226578950882,
-0.14246056973934174,
0.033020373433828354,
-0.22246477007865906,
0.06404591351747513,
-0.2126491218805313,
-0.10289112478494644,
0.1907181590795517,
0.03068728558719158,
0.1498708873987198,
-0.39354977011680603,
-0.12425018101930618,
0.6992021799087524,
0.02937152422964573,
0.09348590672016144,
-0.14638707041740417,
0.8310163021087646,
-0.21336697041988373,
0.4292061924934387,
-0.14052872359752655,
0.2845368981361389,
-0.6354938745498657,
0.2115413397550583,
-0.07262518256902695,
0.09178519994020462,
0.1951318085193634,
-0.9267330765724182,
-0.2253745049238205,
-0.018103543668985367,
-0.511240541934967,
-0.5914760231971741,
-0.10878802090883255,
0.3090951442718506,
-0.16930367052555084,
0.09845094382762909,
0.2090325653553009,
-0.6744900345802307,
0.1673128604888916,
-0.6912151575088501,
-0.29112109541893005,
0.2703639268875122,
-0.22211936116218567,
-0.45786401629447937,
0.01966371014714241,
-0.16583563387393951,
0.22712065279483795,
0.03400776907801628,
-0.03445964306592941,
-0.10704824328422546,
-0.23624590039253235,
0.09108453243970871,
0.2551451027393341,
0.018806712701916695,
0.7778488993644714,
-0.037231262773275375,
-0.057881128042936325,
0.44368675351142883,
0.17170049250125885,
1.0376648902893066,
0.28758692741394043,
0.22668907046318054,
0.5410918593406677,
-0.17726777493953705,
0.5577602386474609,
0.012849289923906326,
-0.7245569825172424,
-1.0907485485076904,
-0.3588641285896301,
-0.4469073712825775,
-0.47269871830940247,
0.006486422382295132,
0.4370975196361542,
-0.6733795404434204,
0.3162156343460083,
-0.21709084510803223,
-0.44881120324134827,
-0.2630021870136261,
0.5633046627044678,
-0.1418287605047226,
0.0014658048748970032,
0.32496243715286255,
0.6615827083587646,
-0.06002584472298622,
0.28543415665626526,
0.12748567759990692,
-0.3281700015068054,
0.20063214004039764,
0.1671973615884781,
-0.7399722933769226,
0.28437525033950806,
0.4216579794883728,
-0.9623731374740601,
0.5470153093338013,
0.10171017795801163,
0.5241991281509399,
-0.18609757721424103,
-0.40108737349510193,
0.019610000774264336,
0.10875852406024933,
-0.3368237614631653,
0.18600979447364807,
0.4878970980644226,
0.5161569118499756,
-0.19412030279636383,
0.13878612220287323,
-0.24411912262439728,
0.44638726115226746,
0.3267207443714142,
-0.12234137952327728,
-0.0761173740029335,
0.0022231752518564463,
-0.2873675525188446,
-0.12605145573616028,
-0.06640990078449249,
-0.2857632339000702,
0.5632191896438599,
0.015240078791975975,
-0.3311026692390442,
0.16846702992916107,
0.5906761288642883,
0.4906312823295593,
-0.3743157982826233,
-0.6050969362258911,
0.08259958028793335,
-0.2343306541442871,
-1.368914246559143,
-0.09883276373147964,
-0.04582589864730835,
-0.5793797969818115,
-0.34406396746635437,
-0.32421040534973145,
-0.18178114295005798,
0.46802592277526855,
0.01930161938071251,
-0.5807499289512634,
0.06541876494884491,
0.06403320282697678,
0.1649473011493683,
-0.16958317160606384,
-0.297597199678421,
0.14077229797840118,
-0.5863891839981079,
0.16167929768562317,
0.06380458921194077,
-0.45693933963775635,
-0.2857968509197235,
0.17600014805793762,
0.6728950142860413,
1.1026434898376465,
-0.29320448637008667,
-0.08623333275318146,
-0.39708608388900757,
0.05602528154850006,
0.03086046315729618,
-0.324951708316803,
0.32488980889320374,
0.06331618875265121,
-0.2312486320734024,
-0.14442147314548492,
-0.2324555665254593,
0.4074356257915497,
-0.22909264266490936,
0.04339967295527458,
-0.16446080803871155,
0.27223116159439087,
-0.2269836813211441,
0.41996023058891296,
0.23658525943756104,
0.05604593828320503,
0.11375048011541367,
-0.15473300218582153,
-0.7791757583618164,
-0.2913309931755066,
-0.10450369864702225,
-0.3911442160606384,
-0.23222610354423523,
0.4299992024898529,
-0.5625954866409302,
0.48021358251571655,
-0.11611255258321762,
-0.34360387921333313,
-0.05092620104551315,
0.3630160093307495,
0.1579190045595169,
0.0353551059961319,
-0.3686164617538452,
-0.14450982213020325,
-0.11826607584953308,
0.4629616141319275,
0.5453099608421326,
-1.3227039575576782,
0.14689110219478607,
0.4030180275440216,
-0.04388604685664177,
-0.2872469425201416,
-0.10255058109760284,
-0.09741909056901932,
-0.576503336429596,
0.0645926371216774,
-0.15807566046714783,
0.16396433115005493,
0.3928660750389099,
0.3882896900177002,
0.06929293274879456,
0.373018741607666,
-0.15381485223770142,
-0.398884654045105,
-0.05263584479689598,
-0.0750759094953537,
0.5653394460678101,
-0.3689683973789215,
-0.4102254807949066,
0.2670026123523712,
0.5295256972312927,
-0.4528205394744873,
0.14753781259059906,
-0.45889705419540405,
0.3675635755062103,
0.5000806450843811,
-0.46582403779029846,
-0.42062175273895264,
0.10350655764341354,
0.49190622568130493,
-0.18629176914691925,
-0.5599090456962585,
-0.42816445231437683,
-0.1864011287689209,
0.2405186891555786,
0.06109130382537842,
-0.07115960121154785,
-0.10464750975370407,
-0.39683908224105835,
-0.43483975529670715,
0.14944374561309814,
0.11637452244758606,
0.7140492796897888,
0.4093133509159088,
0.09584596008062363,
0.009516521356999874,
-0.3249114751815796,
0.40925902128219604,
0.18195150792598724,
0.38347893953323364,
-0.5011191964149475,
-0.4351029098033905,
0.2697288990020752,
-0.06539816409349442,
-0.010316169820725918,
-0.2853336036205292,
0.19540078938007355,
0.26489636301994324,
-0.2914365530014038,
-0.1973896622657776,
0.4208438992500305,
0.041458405554294586,
-0.7159864902496338,
0.013048326596617699,
0.08442399650812149,
0.0951697826385498,
0.12101016193628311,
0.4440769851207733,
0.2878456115722656,
-0.29699698090553284,
-0.3045007884502411,
0.591978132724762,
0.06951002031564713,
-0.2794535756111145,
0.028013592585921288,
0.3163753151893616,
0.4250882565975189,
-0.16159269213676453,
-0.06960872560739517,
0.37068185210227966,
0.020182903856039047,
-0.264634907245636,
0.5169132351875305,
0.3965196907520294,
-0.5821446180343628,
0.0956752747297287,
-0.02327074110507965,
-0.19643549621105194,
0.25588497519493103,
-0.17689862847328186,
0.2599875032901764,
0.5890182256698608,
0.684489369392395,
0.08533132821321487,
-0.18063069880008698,
0.17610657215118408,
-0.24807512760162354,
0.4488765597343445,
0.45096880197525024,
0.12428418546915054,
0.37232232093811035,
0.7807605266571045,
0.014516702853143215,
0.5670384764671326,
0.0009359194664284587,
0.29813989996910095,
-0.30885908007621765,
-0.6071160435676575,
-0.14064978063106537,
0.5199629664421082,
1.010143756866455,
0.3034157454967499,
0.03173986077308655,
-0.15061186254024506,
0.20036135613918304,
0.8139432072639465,
0.02935028076171875,
-0.037938088178634644,
0.33615556359291077,
0.26242539286613464,
-0.16408030688762665,
-0.5127285718917847,
-0.4810977280139923,
0.020892277359962463,
-0.3885090947151184,
0.21171092987060547,
0.1007622554898262,
-0.2076096385717392,
-0.5068269968032837,
-0.10879698395729065,
-0.1655302494764328,
-0.13719655573368073,
-0.33968162536621094,
0.2304374873638153,
-0.2009279876947403,
-0.07919371873140335,
0.5979247093200684,
0.34876832365989685,
0.09663209319114685,
-0.34756597876548767,
0.17992936074733734,
-0.2907373905181885,
-0.38259783387184143,
0.10907108336687088,
0.018773138523101807,
-0.6080436110496521,
-0.12444868683815002,
0.23264580965042114,
-0.25041770935058594,
0.3333476185798645,
-0.49024295806884766,
-0.29543930292129517,
-0.08849048614501953,
-0.278397798538208,
-0.2549331486225128,
-0.27070194482803345,
-0.23636627197265625,
0.03704005107283592,
0.14216874539852142,
0.14457634091377258,
0.03756922483444214,
-0.32170525193214417,
0.12363093346357346,
0.39147916436195374,
-0.43083950877189636,
-0.2673100233078003,
0.09619732201099396,
0.08656512945890427,
0.5309775471687317,
0.19877400994300842,
-0.5161848068237305,
-0.140843465924263,
-0.07034458220005035,
0.2947123348712921,
-0.34862220287323,
0.2336815446615219,
-0.40083378553390503,
-0.1710900217294693,
-0.4966075122356415,
-0.24654467403888702,
0.5204734802246094,
0.3800744414329529,
-0.110495425760746,
0.3704849183559418,
0.1672321856021881,
0.4220159649848938,
0.5254107713699341,
-0.2917061448097229,
-0.21850599348545074,
-0.4186583161354065,
-0.6268833875656128,
-0.9690290093421936,
0.19030612707138062,
-0.002977292286232114,
-0.17341452836990356,
0.22587215900421143,
0.4458184540271759,
0.20059196650981903,
0.029993686825037003,
0.5161710381507874,
-0.41326168179512024,
-0.1616896688938141,
-0.6379080414772034,
0.18610550463199615,
-0.42172297835350037,
0.12731628119945526,
0.38837552070617676,
0.11281894147396088,
0.603679895401001,
-0.22036112844944,
-0.1269325613975525,
-0.5573902130126953,
0.24985644221305847,
0.021209802478551865,
0.34780606627464294,
0.5842666029930115,
-0.23864856362342834,
-0.1603356897830963,
-0.6473403573036194,
0.15159690380096436,
-0.7590805888175964,
-0.14312946796417236,
0.15484033524990082,
-0.1052202358841896,
-0.2513464689254761,
-0.5038015246391296,
-0.08804945647716522,
-0.5057865977287292,
-0.23950989544391632,
0.20148944854736328
] |
Chronic exercise upregulates endothelial nitric oxide synthase (eNOS) gene expression. Whether the expression of inducible nitric oxide synthase (iNOS) is affected by exercise is unknown. We therefore investigated the effects of chronic exercise on iNOS and eNOS expression in isolated rat aortic endothelial and smooth muscle cells separately. Five-week-old male Wistar rats were randomly divided into control and exercise groups. After 10 weeks of running training, animals were sacrificed under ether anesthesia. The standard curve quantitative competitive reverse transcriptase-polymerase chain reaction method was used to quantify NOS mRNA expression in isolated endothelial/smooth muscle cells. To evaluate the functional role of iNOS, we examined phenylephrine-induced vascular responses with or without pretreatment with aminoguanidine. We found that (1) expression of iNOS and eNOS mRNA in endothelial cells was increased by chronic exercise and (2) chronic exercise blunted phenylephrine-induced vascular responses, probably by increasing NO release via iNOS. Our results show that chronic exercise increases both iNOS and eNOS gene expression in endothelium. These alterations may be partially responsible for the change in vascular response after exercise. | [
0.01430271752178669,
-0.005203896202147007,
-0.03527464717626572,
0.047224897891283035,
-0.0035261735320091248,
-0.028944749385118484,
0.012603497132658958,
0.008444787934422493,
-0.015010165981948376,
0.01400048565119505,
-0.015822574496269226,
0.028714986518025398,
-0.026019547134637833,
0.0198813583701849,
0.051941122859716415,
-0.008949900045990944,
-0.02361559495329857,
0.008396798744797707,
0.012643517926335335,
-0.004642142448574305,
0.013189336284995079,
-0.017967622727155685,
0.010382416658103466,
-0.0244559608399868,
0.02562866359949112,
0.010729838162660599,
0.008871129713952541,
-0.0019399560987949371,
-0.020511439070105553,
0.030809596180915833,
-0.0203486829996109,
-0.006042287684977055,
0.007162346970289946,
-0.0002981061115860939,
0.0010295422980561852,
0.01899680867791176,
-0.015061793848872185,
0.030767245218157768,
0.02382832206785679,
-0.007049660198390484,
-0.008089069277048111,
-0.009261365979909897,
0.009488333016633987,
-0.016812438145279884,
-0.011154946871101856,
-0.018006525933742523,
-0.0004760670126415789,
0.03758009895682335,
-0.016491366550326347,
0.009732546284794807,
-0.007173995021730661,
-0.00708008324727416,
-0.023294424638152122,
-0.000736570917069912,
-0.007477154023945332,
0.04485638067126274,
0.019961411133408546,
0.021935107186436653,
-0.03607247397303581,
-0.03383678197860718,
0.03120768815279007,
0.048341184854507446,
-0.004900217987596989,
-0.00210316339507699,
0.0005846410058438778,
-0.06557787954807281,
0.01501714438199997,
0.018683405593037605,
-0.005021537654101849,
-0.010060412809252739,
-0.00021557044237852097,
0.010150587186217308,
0.026691794395446777,
-0.008118382655084133,
0.00576419522985816,
0.017607972025871277,
-0.011358026415109634,
-0.0241027120500803,
0.040270399302244186,
0.014803477562963963,
-0.01106254756450653,
-0.01522248238325119,
-0.004087388515472412,
0.011663386598229408,
-0.001649403478950262,
0.020227856934070587,
-0.032173410058021545,
-0.010631630197167397,
0.045289404690265656,
0.02955767698585987,
-0.005664092488586903,
0.00739238690584898,
-0.013102288357913494,
0.030713260173797607,
-0.011901218444108963,
0.021842235699295998,
0.01553640142083168,
-0.027937468141317368,
0.018090669065713882,
-0.030646387487649918,
-0.02113957330584526,
-0.011112409643828869,
0.02399807795882225,
0.033019132912158966,
0.022842295467853546,
0.01012288499623537,
0.02300427481532097,
0.05656784027814865,
-0.018156124278903008,
0.018199827522039413,
0.027015656232833862,
0.027456296607851982,
0.03269478306174278,
0.042889997363090515,
0.021058566868305206,
0.053883567452430725,
-0.0004525771364569664,
-0.004550330340862274,
0.006891780532896519,
0.0057811252772808075,
0.024128027260303497,
0.016513623297214508,
-0.00473957322537899,
0.026493601500988007,
0.001614479930140078,
0.02765931747853756,
0.0188731849193573,
0.0001060214126482606,
-0.033817846328020096,
-0.0028521716594696045,
-0.009522471576929092,
-0.005987390875816345,
0.019405405968427658,
-0.01778276450932026,
-0.04389089718461037,
-0.01722276769578457,
-0.00575025100260973,
-0.0018861806020140648,
-0.012739798054099083,
-0.022053737193346024,
0.008859549649059772,
0.007789468392729759,
0.006168025080114603,
0.022258371114730835,
0.006669824011623859,
0.00009867176413536072,
0.034475117921829224,
0.0016408339142799377,
-0.009224875830113888,
-0.02949265018105507,
0.029014907777309418,
0.013775549829006195,
0.008095820434391499,
-0.03392857313156128,
0.012885961681604385,
0.04243038594722748,
-0.03286860138177872,
-0.014203488826751709,
-0.012745444662868977,
0.005585370119661093,
-0.08249621093273163,
0.005774824880063534,
0.023370876908302307,
0.010349408723413944,
-0.007672563660889864,
-0.0036371732130646706,
-0.00602180790156126,
-0.0016634276835247874,
0.022196592763066292,
0.008721986785531044,
0.009310047142207623,
-0.053938206285238266,
0.022932937368750572,
0.015597769059240818,
-0.0009068259969353676,
-0.00867894571274519,
0.021516943350434303,
0.008006283082067966,
-0.006555696949362755,
0.06568820774555206,
0.016114136204123497,
0.015075268223881721,
-0.002995702438056469,
0.06524652987718582,
-0.01534283347427845,
-0.015650060027837753,
-0.0039830394089221954,
-0.0013848289381712675,
0.007018260192126036,
-0.018590407446026802,
0.018131813034415245,
0.004062646068632603,
0.00894077867269516,
-0.023274943232536316,
-0.03796743229031563,
0.0030765305273234844,
0.026895031332969666,
-0.0038322866894304752,
-0.026966528967022896,
-0.008225337602198124,
-0.011699452996253967,
-0.009295778349041939,
0.06405555456876755,
0.01784992218017578,
-0.0013342108577489853,
0.03111981227993965,
-0.00234708609059453,
-0.050479307770729065,
-0.010470351204276085,
0.009081650525331497,
0.02186206355690956,
-0.004117995500564575,
-0.007095749489963055,
-0.033414971083402634,
0.02883230149745941,
0.008000216446816921,
-0.005538155324757099,
0.013416697271168232,
-0.023519109934568405,
-0.015734774991869926,
-0.0038601341657340527,
0.048939552158117294,
-0.03127665817737579,
-0.03314796835184097,
0.0015662630321457982,
-0.011483360081911087,
0.010964352637529373,
0.017123878002166748,
-0.011066947132349014,
0.003703838912770152,
-0.014785507693886757,
0.005863952450454235,
-0.014961546286940575,
0.020672081038355827,
0.01792716607451439,
-0.004711339715868235,
0.017105625942349434,
-0.01734672114253044,
0.018409309908747673,
-0.012119919061660767,
0.0002582462038844824,
-0.03284742310643196,
0.015542580746114254,
-0.005212979856878519,
-0.00525294803082943,
0.028036270290613174,
0.008748767897486687,
-0.012646380811929703,
0.021046936511993408,
0.007892818190157413,
0.011926984414458275,
-0.02556512877345085,
-0.03494291380047798,
-0.029158763587474823,
-0.00900962669402361,
-0.038079045712947845,
-0.00454997643828392,
-0.02625182829797268,
0.027358604595065117,
-0.022882012650370598,
-0.004021866712719202,
0.008563723415136337,
0.017735593020915985,
0.031121857464313507,
-0.035755403339862823,
0.015832122415304184,
0.002474079839885235,
-0.016149938106536865,
0.030139191076159477,
-0.004406794905662537,
0.013432287611067295,
-0.005700256675481796,
-0.01119091734290123,
-0.08063875883817673,
0.002503350842744112,
0.007756803184747696,
-0.02116169035434723,
0.005413825623691082,
-0.00835062563419342,
0.010240370407700539,
0.03215599060058594,
-0.009740911424160004,
0.01682478003203869,
-0.0004892735742032528,
-0.03252474218606949,
-0.002057899022474885,
0.01275908574461937,
-0.010165237821638584,
0.00706365704536438,
0.015516366809606552,
0.02385813742876053,
-0.0058631617575883865,
-0.0055277529172599316,
-0.004574034828692675,
0.008033948950469494,
-0.022029180079698563,
0.02349032275378704,
-0.020919937640428543,
0.01241131778806448,
-0.0063079041428864,
-0.024372480809688568,
0.01833677664399147,
0.01365140825510025,
-0.01160936988890171,
0.0007868953980505466,
0.0011689607053995132,
-0.001068645273335278,
0.03184603154659271,
0.03556313365697861,
-0.038922641426324844,
-0.012894242070615292,
0.014758488163352013,
0.023932594805955887,
0.004040582105517387,
0.00445931451395154,
0.01669299229979515,
0.003564246464520693,
0.011487046256661415,
0.009149376302957535,
0.019312430173158646,
0.0237400121986866,
0.010182349942624569,
0.009131480008363724,
0.019680455327033997,
-0.017478708177804947,
0.011192325502634048,
0.01822517067193985,
-0.019306551665067673,
0.005886422004550695,
-0.0010902658104896545,
-0.029283229261636734,
-0.0018032821826636791,
-0.02038496360182762,
0.03667400777339935,
0.023047126829624176,
0.018768757581710815,
0.019266335293650627,
0.038233671337366104,
-0.02197244018316269,
0.0054005589336156845,
0.018015803769230843,
-0.02072228118777275,
0.0278762336820364,
-0.02282344549894333,
0.005651997402310371,
-0.019436687231063843,
-0.0022160387597978115,
-0.04374963417649269,
-0.014841682277619839,
-0.0207199789583683,
-0.00625669676810503,
0.03412782400846481,
0.010043006390333176,
-0.0033710640855133533,
-0.0006855070241726935,
-0.022282633930444717,
-0.0146043561398983,
-0.03206020966172218,
-0.014482789672911167,
0.008466275408864021,
-0.0036661666817963123,
0.021819032728672028,
-0.02338314801454544,
0.008283626288175583,
0.03129218891263008,
0.004514968954026699,
0.012123599648475647,
-0.0026008703280240297,
-0.004059932194650173,
0.003493746742606163,
0.0028583956882357597,
0.01968328282237053,
0.00819422397762537,
-0.03985132277011871,
-0.01229516789317131,
0.041257862001657486,
-0.01295658852905035,
-0.009452464058995247,
0.008897392079234123,
0.02546929195523262,
-0.032380566000938416,
0.004568025469779968,
-0.005510562565177679,
-0.023755058646202087,
-0.03668571263551712,
-0.009156507439911366,
0.001877475529909134,
0.014965551905333996,
0.009221218526363373,
-0.00043400004506111145,
0.001944842515513301,
0.0711524710059166,
0.015279149636626244,
-0.00023249792866408825,
-0.026741046458482742,
0.023594576865434647,
-0.017968202009797096,
0.003725315211340785,
-0.0002505166921764612,
-0.018248792737722397,
-0.016172010451555252,
0.014375880360603333,
-0.004480572417378426,
-0.0014578187838196754,
0.03895463049411774,
-0.013129308819770813,
-0.01704910770058632,
-0.0012504541082307696,
-0.0295028667896986,
-0.024122821167111397,
0.010411204770207405,
0.001938321627676487,
-0.01573178730905056,
-0.03386545553803444,
-0.016934745013713837,
0.008906329050660133,
-0.03784964606165886,
0.004165079444646835,
-0.013812743127346039,
-0.012458933517336845,
0.008915459737181664,
-0.03772880136966705,
-0.02767273038625717,
-0.009787486866116524,
-0.01435878872871399,
-0.004974169656634331,
-0.00006378907710313797,
0.007889716885983944,
-0.005430151242762804,
-0.003903851145878434,
-0.02566288784146309,
-0.011405201628804207,
-0.022845428436994553,
0.014515846036374569,
0.015008628368377686,
0.018724650144577026,
0.003395499661564827,
-0.006389147602021694,
-0.003370516700670123,
0.0024609190877527,
0.021863196045160294,
-0.01302980724722147,
0.02223578840494156,
0.003980990964919329,
-0.0056999120861291885,
-0.01969161629676819,
0.01969113014638424,
-0.002808425109833479,
-0.008220690302550793,
0.03944854438304901,
0.023232975974678993,
0.01803884282708168,
-0.025010129436850548,
0.008669046685099602,
0.006706412881612778,
0.005557658150792122,
-0.01567293144762516,
-0.013093505054712296,
0.024473465979099274,
-0.012534437701106071,
0.013498480431735516,
-0.01594429835677147,
0.01949244737625122,
0.002780753653496504,
0.019345596432685852,
-0.01526610180735588,
-0.008597247302532196,
-0.011929191648960114,
-0.0033247987739741802,
0.03669185936450958,
-0.0075187417678534985,
-0.03044046089053154,
0.009431863203644753,
0.003470225492492318,
0.0012675635516643524,
0.04391101002693176,
0.01992417685687542,
-0.047880299389362335,
-0.07429416477680206,
-0.011501235887408257,
0.02616332843899727,
-0.008798387832939625,
0.02202736586332321,
0.011298118159174919,
-0.03631114587187767,
0.01697690412402153,
-0.003892968874424696,
-0.008365749381482601,
-0.03872447460889816,
0.029962388798594475,
-0.007650978863239288,
-0.012677837163209915,
0.01278920378535986,
-0.011517099104821682,
-0.007811401970684528,
-0.010463384911417961,
-0.0035869525745511055,
-0.026404380798339844,
-0.036821503192186356,
0.0816536471247673,
-0.01721213385462761,
0.0058044372126460075,
-0.0030544803012162447,
-0.0799054205417633,
-0.0007882150821387768,
0.018632562831044197,
-0.021505601704120636,
0.016715558245778084,
0.037479184567928314,
-0.007105165161192417,
-0.014943676069378853,
0.06364476680755615,
-0.021152788773179054,
0.007671696599572897,
0.005140866152942181,
0.023648571223020554,
-0.03942295163869858,
0.024914536625146866,
-0.013012846000492573,
0.019403673708438873,
0.014346117153763771,
-0.009081872180104256,
-0.0057456474751234055,
-0.013314345851540565,
0.009286295622587204,
-0.006756609305739403,
0.0009177455212920904,
-0.008999173529446125,
-0.009245460852980614,
0.0001964205875992775,
0.016870075836777687,
0.027587922289967537,
0.00043243076652288437,
-0.00035105703864246607,
-0.002622390864416957,
-0.012169351801276207,
0.005986708216369152,
-0.02047080174088478,
-0.015974245965480804,
-0.019765334203839302,
-0.0027414439246058464,
-0.021570030599832535,
-0.001702380133792758,
-0.006824853830039501,
-0.024336054921150208,
0.04736551642417908,
0.009451420046389103,
-0.04557529091835022,
-0.04422246664762497,
0.010703792795538902,
-0.020322665572166443,
0.004625954665243626,
-0.015285572037100792,
-0.0002055229269899428,
0.0251519363373518,
0.03438996896147728,
0.009099353104829788,
0.009882742539048195,
0.039395950734615326,
-0.008320610970258713,
0.016435744240880013,
-0.012731191702187061,
0.005453034304082394,
-0.011886768974363804,
0.016756383702158928,
-0.0058197686448693275,
0.07071667909622192,
0.019063420593738556,
-0.00989818200469017,
0.013205323368310928,
0.006696544121950865,
0.003306692698970437,
0.034091029316186905,
-0.028615467250347137,
-0.02724120020866394,
-0.004849937744438648,
-0.008754241280257702,
-0.01164967566728592,
-0.0030215182341635227,
0.01707369089126587,
0.018518012017011642,
-0.015685414895415306,
0.03116394579410553,
0.04118196666240692,
-0.0027102893218398094,
-0.0017600527498871088,
-0.004275367129594088,
-0.0020356914028525352,
-0.003181450068950653,
0.0026392946019768715,
0.0042768544517457485,
-0.022420411929488182,
0.01020018756389618,
0.011975400149822235,
-0.020357824862003326,
-0.0004572229227051139,
0.007965590804815292,
-0.012108800932765007,
0.0033607936929911375,
0.009572731330990791,
0.018388863652944565,
0.012532699853181839,
-0.007599908858537674,
0.017032543197274208,
-0.024582285434007645,
0.010200911201536655,
0.02561946213245392,
0.0182059183716774,
0.009071405045688152,
0.002287101000547409,
-0.00737012131139636,
0.03087111935019493,
0.006159867625683546,
-0.02587408944964409,
0.008637731894850731,
-0.004733608104288578,
0.0012443000450730324,
0.01076426450163126,
-0.029938098043203354,
-0.021347051486372948,
0.0201256200671196,
0.0380324125289917,
0.01570458710193634,
0.030483396723866463,
-0.01588606834411621,
0.006637744605541229,
0.018151557072997093,
-0.006930257193744183,
-0.010253563523292542,
-0.029818858951330185,
0.00922376662492752,
-0.0038653286173939705,
0.02335008606314659,
-0.008562508970499039,
-0.02442958950996399,
0.01620516926050186,
0.0039766281843185425,
0.02544509992003441,
0.009855115786194801,
0.021316945552825928,
0.041581891477108,
-0.00021046120673418045,
0.013075513765215874,
-0.019003061577677727,
-0.000002314336597919464,
0.005078761838376522,
-0.01902921497821808,
0.04126257821917534,
-0.020029539242386818,
-0.01889851689338684,
-0.003909035120159388,
-0.01268627867102623,
-0.005184208042919636,
0.012678967788815498,
-0.0012806258164346218,
0.019515488296747208,
0.00033961981534957886,
0.009930737316608429,
0.01025170274078846,
0.020442863926291466,
0.012765144929289818,
0.03533457964658737,
0.05808049440383911,
0.005597498267889023,
-0.021561425179243088,
-0.017322974279522896,
-0.002545533701777458,
-0.015276139602065086,
-0.0005887479055672884,
-0.016655225306749344,
-0.015325941145420074,
-0.006730479653924704,
0.020154966041445732,
-0.019592847675085068,
-0.01571102999150753,
0.00765463849529624,
0.013447027653455734,
0.008546759374439716,
0.018019720911979675,
0.010076906532049179,
0.04758838191628456,
0.024688735604286194,
-0.00984302256256342,
-0.0436013862490654,
-0.02146388404071331,
-0.01573372446000576,
-0.006826622411608696,
-0.007561960257589817,
0.015006408095359802,
-0.010101668536663055,
-0.004833959974348545,
-0.028928695246577263,
-0.016325296834111214,
-0.0048792678862810135,
0.029911816120147705,
-0.017744850367307663,
0.02228035032749176,
0.021609749644994736,
-0.030046746134757996,
0.013485594652593136,
-0.004581430461257696,
0.004429054446518421,
0.02316700853407383,
0.01322746742516756,
-0.02869896963238716,
-0.002472453285008669,
0.0010593542829155922,
-0.0016474962467327714,
-0.004718632437288761,
-0.011683546006679535,
0.00690064812079072,
-0.01495327427983284,
0.031493429094552994,
0.03326690196990967,
0.013448835350573063,
0.025971699506044388,
0.004727161023765802,
0.004332843702286482,
0.0071909609250724316,
-0.005950912833213806,
-0.026382390409708023,
0.01933411881327629,
0.010364232584834099,
-0.008028507232666016,
0.006660133600234985,
-0.0238981731235981,
0.01702229119837284,
0.00751072634011507,
0.03778320923447609,
-0.0032950236927717924,
0.014837156049907207,
-0.03188114985823631,
-0.01706782355904579,
0.0033272244036197662,
-0.03252524510025978,
0.018061866983771324,
0.02076655626296997,
-0.003710015444085002,
-0.011130128987133503,
0.036942001432180405,
-0.02238774672150612,
-0.013388490304350853,
-0.0011854073964059353,
0.010552757419645786,
0.017829440534114838,
0.03755766898393631,
0.023031122982501984,
-0.017443552613258362,
-0.025512181222438812,
-0.018964413553476334,
0.016878584399819374,
-0.0014210205990821123,
-0.006652276962995529,
-0.010076415725052357,
-0.0024540466256439686,
0.04308595880866051,
-0.006311619654297829,
-0.01923391781747341,
-0.005013441666960716,
0.012039072811603546,
-0.023120414465665817,
-0.0017454428598284721,
0.0017854210454970598,
-0.021005500108003616,
0.019736599177122116,
-0.005765726324170828,
-0.015089836902916431,
-0.002829901408404112
] | [
-0.04804877191781998,
-0.11036212742328644,
-0.23886552453041077,
-0.02404371090233326,
0.2167472541332245,
0.1483842432498932,
0.3745766878128052,
-0.17034325003623962,
0.0973273366689682,
-0.3431375026702881,
0.2870473563671112,
0.618353009223938,
-0.2124776393175125,
-0.6386756300926208,
-0.15955694019794464,
0.4684944450855255,
0.6850846409797668,
0.24606108665466309,
-0.0589999221265316,
-0.5876758098602295,
-0.23099270462989807,
-0.36174750328063965,
0.5621969699859619,
-0.007781716994941235,
-0.231675386428833,
-0.041025418788194656,
0.2004144936800003,
0.0954943373799324,
-0.028836827725172043,
-0.2081490457057953,
-0.29232701659202576,
0.6530422568321228,
-0.07724130898714066,
-0.3912711441516876,
-0.14872844517230988,
0.34868869185447693,
-0.04856960475444794,
0.046746667474508286,
0.0026592565700411797,
-0.4223296344280243,
-0.045114293694496155,
-0.1007191613316536,
0.061494406312704086,
0.11375727504491806,
-0.21494083106517792,
0.1417703926563263,
-1.1385254859924316,
0.3669034242630005,
0.02323947846889496,
0.014812021516263485,
-0.08331634849309921,
0.2904488444328308,
0.44385141134262085,
-0.006971314549446106,
0.13475769758224487,
0.06832650303840637,
-0.5221121907234192,
-0.027900470420718193,
-0.023901797831058502,
-0.596245288848877,
0.5562230348587036,
0.12571834027767181,
-0.6141077876091003,
0.15759478509426117,
-0.5789002180099487,
0.5442603826522827,
-0.014926902949810028,
-0.2911471426486969,
-0.12008912861347198,
0.3147974908351898,
0.42851147055625916,
-0.04149845987558365,
-0.2730536460876465,
0.4326820373535156,
0.061878010630607605,
0.08930162340402603,
-0.34033501148223877,
-0.095741406083107,
-0.2007676512002945,
0.02949538826942444,
0.20716039836406708,
0.1299819052219391,
0.827018678188324,
-0.27676498889923096,
0.41289377212524414,
-0.14033310115337372,
0.19195042550563812,
0.7205668687820435,
-0.4798659682273865,
-0.40479621291160583,
-0.18145661056041718,
0.19849996268749237,
0.4875727593898773,
0.4592622220516205,
-0.0192987360060215,
0.3745346963405609,
0.003723511006683111,
-0.14549195766448975,
0.054355114698410034,
0.013372051529586315,
-0.0192162673920393,
-0.003041344229131937,
-0.33508893847465515,
-0.20315206050872803,
-0.5949187278747559,
-0.12332631647586823,
0.10086186975240707,
-0.41569697856903076,
-0.17805184423923492,
0.41860657930374146,
-1.1338474750518799,
-0.2217198610305786,
-0.3928375244140625,
-0.7143650650978088,
-0.35673514008522034,
-0.03705339878797531,
-0.21262016892433167,
0.07405964285135269,
0.02709578536450863,
0.10258350521326065,
-0.2889987528324127,
0.7476755976676941,
-0.16571691632270813,
0.5391299724578857,
-0.47961556911468506,
0.036198653280735016,
0.4158306121826172,
-0.022311817854642868,
0.4847118556499481,
0.3952164053916931,
0.2935796082019806,
0.6198030710220337,
-0.1796262264251709,
0.012537697330117226,
0.22883152961730957,
-0.05727717652916908,
0.5428375005722046,
0.34686219692230225,
0.43196433782577515,
0.4192289412021637,
-0.39691030979156494,
-0.5210995674133301,
-0.3186434805393219,
0.14511962234973907,
-0.34662774205207825,
-0.5608127117156982,
-0.08858746290206909,
-0.1045944020152092,
0.37607231736183167,
-0.14056485891342163,
0.07636930793523788,
-0.3948829472064972,
-0.5527439713478088,
-0.11224409192800522,
0.17543263733386993,
0.19921374320983887,
-0.638043224811554,
-0.37341055274009705,
0.06436100602149963,
0.20203448832035065,
0.3484092950820923,
-0.2694604992866516,
-0.15635620057582855,
0.08069181442260742,
0.6534423828125,
0.04761960357427597,
-0.2725367248058319,
0.2637786567211151,
-0.09401611238718033,
0.1804078370332718,
-0.23452678322792053,
-0.432813435792923,
0.20328456163406372,
-0.4020695090293884,
-0.24708285927772522,
0.27002397179603577,
0.042276035994291306,
0.3465750813484192,
0.026133188977837563,
0.03861115872859955,
-0.7730876207351685,
-0.14152903854846954,
0.07709134370088577,
-0.28127917647361755,
1.0177233219146729,
-0.04455604776740074,
0.09766361862421036,
0.17169645428657532,
0.07328584790229797,
0.10342615097761154,
-0.6551994681358337,
-0.3993161618709564,
1.1390652656555176,
-0.8155652284622192,
1.3672072887420654,
-0.24582359194755554,
-0.20938390493392944,
0.7563377022743225,
0.1389905959367752,
-0.020002931356430054,
0.18287231028079987,
-0.35050955414772034,
0.9906082153320312,
-0.31588053703308105,
-0.4948422908782959,
0.09093356877565384,
-0.26656877994537354,
-0.46190345287323,
-0.04128536209464073,
0.017647292464971542,
-0.11420995742082596,
-0.09421643614768982,
-0.38517171144485474,
-0.10015881061553955,
0.07326710969209671,
-0.3571239113807678,
0.0802895575761795,
-0.027397971600294113,
-0.3692379295825958,
-0.14200730621814728,
0.5263561010360718,
-0.36779993772506714,
0.5921592712402344,
0.6620370745658875,
-0.07238193601369858,
0.5724946856498718,
0.4300875663757324,
0.12402255833148956,
0.81449294090271,
-0.6388924717903137,
0.12726551294326782,
-0.4647904634475708,
-0.02924656867980957,
-0.2478746473789215,
0.3805721700191498,
0.22038710117340088,
0.28882458806037903,
-0.2662235498428345,
0.2623235881328583,
-0.25836142897605896,
0.09325046837329865,
0.4696351885795593,
-0.6963261961936951,
0.20712237060070038,
-0.05612226203083992,
-0.01899925246834755,
-0.16356118023395538,
0.6671292185783386,
-1.5322916507720947,
-0.17770229279994965,
0.4490964710712433,
0.34355735778808594,
0.17086662352085114,
-0.4746714234352112,
-0.21790437400341034,
-0.07878635823726654,
-0.17322616279125214,
-0.241627499461174,
0.03443678468465805,
-0.6963435411453247,
-0.38344812393188477,
0.11495181918144226,
0.3199390470981598,
0.3798569142818451,
0.2972705364227295,
-0.33621668815612793,
-0.9552374482154846,
-0.6100884675979614,
0.7783915996551514,
0.3056904673576355,
1.0608205795288086,
0.16533946990966797,
-0.650898277759552,
-0.08259735256433487,
-0.3428950607776642,
-0.20006714761257172,
-0.2818617522716522,
0.41560566425323486,
-0.40512990951538086,
-0.14320029318332672,
0.059875305742025375,
0.6647582650184631,
0.6242052316665649,
-0.0103022251278162,
-0.04343956708908081,
0.21259132027626038,
-0.4518846273422241,
-0.10577616095542908,
-0.5073888301849365,
-0.5278785228729248,
0.1432827264070511,
0.48231473565101624,
-0.29440629482269287,
0.009742631576955318,
0.4507544934749603,
0.07784262299537659,
0.09993144869804382,
0.6926198601722717,
0.8439345359802246,
-0.07760211080312729,
0.22698751091957092,
0.12388797104358673,
-0.37997496128082275,
0.243509441614151,
-0.20297515392303467,
-0.31535571813583374,
-0.5330708622932434,
0.20432649552822113,
-5.9069929122924805,
0.5947706699371338,
-0.3227299749851227,
-0.3255631923675537,
-0.10295260697603226,
-0.10217940807342529,
0.4547991454601288,
0.0637083426117897,
-0.22192524373531342,
0.32059967517852783,
0.04003247991204262,
0.3683764338493347,
0.3779800236225128,
0.1467084139585495,
-0.24032601714134216,
-0.09749556332826614,
0.08117364346981049,
-0.3919007182121277,
0.33174964785575867,
0.1395784616470337,
0.4599759578704834,
-0.1731456220149994,
-0.1894172579050064,
0.7031874656677246,
0.08884671330451965,
0.300692081451416,
-0.6036624908447266,
-0.028075717389583588,
-0.2821987271308899,
-0.684321939945221,
-0.015865908935666084,
-0.6036633253097534,
0.04425963759422302,
-0.023753346875309944,
0.5143393278121948,
0.18555636703968048,
0.3183540999889374,
-0.14061498641967773,
0.22797997295856476,
-0.6389407515525818,
-0.2738274931907654,
-0.4154126048088074,
-0.3727341294288635,
0.17901135981082916,
0.1440928429365158,
0.5650009512901306,
0.257037490606308,
-0.1641332060098648,
-0.1141747459769249,
0.676287055015564,
-0.09693072736263275,
-0.09583359211683273,
0.38275837898254395,
0.6986279487609863,
0.11172230541706085,
0.0226497333496809,
-0.5366045236587524,
0.05100814998149872,
-0.2508344054222107,
0.2530612051486969,
-0.5891656279563904,
-0.14738456904888153,
-0.6756353378295898,
-0.8207288980484009,
0.08499690890312195,
0.6476738452911377,
-0.2469482421875,
-0.44603195786476135,
0.4389785826206207,
0.30281415581703186,
0.08821237832307816,
0.1390736699104309,
0.4284311532974243,
-0.7240005731582642,
0.7076648473739624,
-0.4247515797615051,
0.2473922073841095,
0.19530682265758514,
-0.11928649246692657,
-0.24327948689460754,
-0.04883093386888504,
-0.48887747526168823,
-0.10706299543380737,
-0.22087255120277405,
0.05254173278808594,
-0.5522100925445557,
-0.007608630228787661,
-0.2538816034793854,
0.19984892010688782,
0.36519962549209595,
0.8311809301376343,
-0.21796327829360962,
-0.16363437473773956,
0.5126769542694092,
0.21335932612419128,
0.5267921686172485,
0.421471506357193,
0.6377822160720825,
0.6079848408699036,
0.008124195970594883,
0.5322216749191284,
-0.12923315167427063,
0.15562868118286133,
-0.7386521100997925,
-0.39174190163612366,
0.12778429687023163,
-0.7501070499420166,
0.09854251891374588,
0.7482015490531921,
-0.7772403359413147,
0.13943414390087128,
-0.2529161274433136,
-0.6506805419921875,
-0.17603528499603271,
0.427786260843277,
-0.06491293758153915,
-0.14824557304382324,
0.09429681301116943,
0.832013726234436,
-0.27280813455581665,
0.38203534483909607,
0.031971972435712814,
-0.23247936367988586,
-0.23205475509166718,
-0.17777952551841736,
0.10613907873630524,
0.3501414358615875,
0.6902434229850769,
-0.9788107872009277,
-0.18746714293956757,
-0.012114576064050198,
0.4683351218700409,
-0.23855702579021454,
0.11617380380630493,
-0.22092601656913757,
-0.5249300003051758,
-0.4614953100681305,
0.24167267978191376,
0.15936900675296783,
0.09016662836074829,
0.36343589425086975,
-0.07691314071416855,
-0.06803282350301743,
0.04555720090866089,
-0.006988321430981159,
0.19334547221660614,
-0.08263355493545532,
-0.6724841594696045,
-0.1212841272354126,
0.10890395939350128,
0.37534356117248535,
-0.4046088755130768,
-0.04850543662905693,
0.3187488615512848,
-0.6486174464225769,
0.2278222292661667,
0.08173593133687973,
-0.0818461999297142,
0.35612908005714417,
-0.5495358109474182,
0.21980136632919312,
0.1797534078359604,
-1.3419520854949951,
-0.11234229058027267,
-0.3508831262588501,
-0.4225273132324219,
-0.08700740337371826,
-0.6358866691589355,
-0.1834222972393036,
0.13738283514976501,
-0.1797776073217392,
-0.025450268760323524,
0.3149589002132416,
0.11261259764432907,
-0.011946721002459526,
-0.5515918135643005,
-0.3988071382045746,
0.07030662894248962,
0.14893664419651031,
0.20071253180503845,
0.26731592416763306,
-0.05937857925891876,
-0.3672669231891632,
0.241120845079422,
0.748062252998352,
-0.08931425213813782,
-0.052304405719041824,
0.12343676388263702,
-0.20089247822761536,
-0.00563028734177351,
0.6675589680671692,
-0.01203242689371109,
0.4956132173538208,
-0.16067354381084442,
0.029199862852692604,
0.34046295285224915,
0.22361774742603302,
1.017939567565918,
-0.1752750724554062,
0.09582233428955078,
-0.021441608667373657,
0.050806403160095215,
-0.23894177377223969,
0.2758946120738983,
0.10509797930717468,
0.03751933202147484,
-0.625489354133606,
-0.08838469535112381,
-0.3115469515323639,
-0.36900943517684937,
-0.35721781849861145,
-0.6828351616859436,
0.05544019117951393,
0.019834281876683235,
-0.23034192621707916,
0.37689271569252014,
-0.032994214445352554,
-0.7630800008773804,
-0.5479795932769775,
0.26616814732551575,
0.2349955141544342,
0.14709532260894775,
-0.7002047896385193,
-0.03076951950788498,
-0.29669708013534546,
-0.2573014795780182,
0.28486889600753784,
-1.0525139570236206,
0.11526759713888168,
-0.0388544425368309,
-0.41942334175109863,
0.19663572311401367,
0.31527402997016907,
0.005362857133150101,
-0.2194661647081375,
-0.17830610275268555,
0.13658680021762848,
0.1871073842048645,
-0.184754878282547,
0.40168294310569763,
-0.018670478835701942,
0.43406710028648376,
-0.17009200155735016,
-0.07551947981119156,
0.18820543587207794,
0.31566721200942993,
-0.13773737847805023,
-0.5478352308273315,
-0.2006903439760208,
-0.01475704275071621,
0.7950528860092163,
0.21788987517356873,
0.033562514930963516,
0.3486359119415283,
0.9741876125335693,
0.02787514589726925,
0.13321970403194427,
-0.6166314482688904,
-0.2174345701932907,
0.01707821898162365,
0.13916131854057312,
0.4211598038673401,
-0.19169259071350098,
0.3070647418498993,
0.2637031674385071,
0.07865247130393982,
0.23659653961658478,
-0.6513603925704956,
0.8434855937957764,
-0.5047769546508789,
0.3239322304725647,
-0.03492071479558945,
0.3738088011741638,
0.571670651435852,
0.2761489748954773,
0.17336219549179077,
-0.3614979088306427,
-0.17870105803012848,
-0.008566133677959442,
0.24608342349529266,
-0.09217175841331482,
-0.5848411321640015,
-0.050783541053533554,
-0.09212107956409454,
0.2829388678073883,
-0.5844379663467407,
0.06822656095027924,
-0.4448096454143524,
-0.29952678084373474,
0.11689645797014236,
-0.09215286374092102,
-0.05254238471388817,
-0.4125749170780182,
-0.5999600291252136,
-0.048916906118392944,
0.3634406626224518,
0.04402141645550728,
-0.2790501117706299,
-0.2366064041852951,
-0.3912937343120575,
-0.9556540250778198,
0.5635086297988892,
0.8930477499961853,
-0.2478499859571457,
-0.22619670629501343,
0.42114317417144775,
0.4252851605415344,
-0.06679043918848038,
-0.6226944327354431,
-0.08163557201623917,
0.5141894221305847,
-0.22263717651367188,
0.08224140852689743,
0.15300352871418,
-0.3807743191719055,
-0.06315040588378906,
-0.5579470992088318,
0.19680655002593994,
0.4115951955318451,
0.3291545808315277,
0.4263051152229309,
0.5339189767837524,
0.7485177516937256,
0.11946077644824982,
-0.25200507044792175,
0.6053847074508667,
0.035123758018016815,
0.06020953506231308,
0.5227833986282349,
0.5026074051856995,
0.544235348701477,
0.1865309774875641,
0.10609403997659683,
0.5143840909004211,
0.38771045207977295,
0.05492561683058739,
0.17060896754264832,
-0.47789227962493896,
-0.47021734714508057,
-0.07938173413276672,
1.1068201065063477,
0.17489245533943176,
0.019903359934687614,
0.2031681388616562,
0.15184776484966278,
0.213025763630867,
0.02507227100431919,
0.05286715179681778,
-0.043294355273246765,
-0.43349024653434753,
0.24926933646202087,
-0.16266779601573944,
-0.30328890681266785,
0.22321061789989471,
-0.4444634020328522,
0.2421211153268814,
0.13559353351593018,
-0.0974060669541359,
-0.5473938584327698,
0.6129465103149414,
-0.23534710705280304,
0.19320574402809143,
-0.024724081158638,
0.1267741322517395,
0.1077953428030014,
-0.16109952330589294,
0.1957615315914154,
0.2579409182071686,
0.33279988169670105,
0.012206965126097202,
0.10887914896011353,
-0.03919458016753197,
-0.5400132536888123,
-0.19599270820617676,
0.1451069861650467,
-0.6159936189651489,
-0.06142470985651016,
-0.03272901847958565,
-0.08414057642221451,
0.567153811454773,
-0.5028320550918579,
0.5641542673110962,
-0.2206660956144333,
-0.3184014558792114,
0.14585626125335693,
-0.20499353110790253,
-0.4336619973182678,
-0.1669577956199646,
-0.008737873286008835,
0.11903244256973267,
0.26698336005210876,
-0.24554914236068726,
0.11286251991987228,
0.07843783497810364,
0.27353525161743164,
-0.12772361934185028,
-0.1286139339208603,
0.33118778467178345,
0.3807017207145691,
0.06342608481645584,
0.3434160649776459,
0.1420639306306839,
-0.31909894943237305,
-0.06542253494262695,
-0.5373615026473999,
0.8194935321807861,
-0.6514495611190796,
-0.22858178615570068,
-0.4983486533164978,
0.12149108201265335,
0.8164102435112,
0.9561436176300049,
-0.07572431862354279,
0.5285325646400452,
0.4414505362510681,
0.12084615975618362,
0.511860191822052,
-1.138413906097412,
-0.584343433380127,
-0.42255762219429016,
-0.344633013010025,
-0.3815532624721527,
0.557830810546875,
-0.3093525469303131,
-0.4108727276325226,
-0.07844781130552292,
0.5975446105003357,
0.08237793296575546,
-0.102887824177742,
0.2057615965604782,
-0.31476110219955444,
-0.0005029794992879033,
-0.5285276174545288,
0.20652297139167786,
-0.6940690279006958,
0.22061002254486084,
-0.11048946529626846,
-0.0651932805776596,
0.0750579908490181,
0.04754938185214996,
0.24683262407779694,
-0.3528909385204315,
-0.1589660346508026,
-0.02094261348247528,
0.36300063133239746,
0.1275467723608017,
-0.17724019289016724,
-0.7807295322418213,
-0.3712064325809479,
0.15625067055225372,
-0.008437534794211388,
-0.2611200213432312,
-0.3292388916015625,
-0.21560387313365936,
0.00444438774138689,
0.01897372491657734,
0.23352956771850586,
-0.3081475794315338,
-0.3803112208843231,
-0.10799065232276917
] |
The frontal lobe is the largest lobe of the brain, and it is thus commonly involved in stroke. Moreover, almost one in five strokes is limited to the prerolandic areas. This high frequency of anatomical involvement is in sharp contrast with the apparent rarity of clinical frontal dysfunction in stroke. It is remarkable that frontal behavioral syndromes have been rather uncommonly reported in patients with stroke as compared to patients with other diseases, such as brain tumor. This fact is paradoxical, because an acute process (stroke) is expected to yield more clinical dysfunction than a more chronic disease (tumor). A volume effect may be the main factor leading to this phenomenon. Another interesting aspect of frontal strokes is the contribution of so-called 'silent' strokes, the recurrence of which may nevertheless lead to intellectual decline and compromise recovery from another stroke with more specific neurologic dysfunction. The contribution of stroke to understanding of frontal lobe dysfunction is important, because of the focal nature of this disease, and great opportunity for clinical-topographic classification correlations. One of the first modern attempts to develop a clinical-topographic classification of frontal lobe lesions came from the school of Luria, who tried to delineate three main types of frontal lobe syndromes (premotor syndrome, prefrontal syndrome, medial-frontal syndrome). Recent anatomic correlates using MRI make it possible to improve this classification. We suggest considering six main clinical-anatomic frontal stroke syndromes: (1) prefrontal; (2) premotor; (3) superior medial; (4) orbital-medial; (5) basal forebrain; (6) white matter. Finally, another fascinating topic relates to frontal lobe symptomatology due to stroke sparing the frontal cortex or white matter. This occurs mainly in three instances: lenticulo-capsular stroke, caudate stroke, and thalamic stroke. Studies using blood flow or metabolism measurements suggest that diaschisis (frontal lobe dysfunction from a remote lesion) may play a role. We believe that this is more likely to be related to dynamic interruption of complex circuitry than to static frontal lobe deactivation. | [
-0.016561191529035568,
-0.003147206036373973,
-0.012495763599872589,
0.011747083626687527,
0.036040402948856354,
-0.006697171367704868,
0.009581447578966618,
0.024400876834988594,
-0.013493250124156475,
0.015176510438323021,
-0.006343601271510124,
0.018044933676719666,
-0.007722756825387478,
0.032940737903118134,
-0.02468547597527504,
0.03478080406785011,
-0.04209238663315773,
0.03823785483837128,
0.003884053323417902,
0.006638844031840563,
0.0365014411509037,
-0.009047793224453926,
0.010493781417608261,
0.0007061418145895004,
-0.016034554690122604,
-0.018515370786190033,
-0.006399134173989296,
-0.005542044062167406,
0.012332169339060783,
0.01829519495368004,
0.005991300567984581,
0.010636623948812485,
-0.004463791381567717,
0.008934875950217247,
0.011738874018192291,
-0.013058869168162346,
0.0024458998814225197,
0.011217829771339893,
-0.026476025581359863,
-0.003357449546456337,
-0.0030039637349545956,
-0.0056429049000144005,
0.004616469144821167,
-0.005966113414615393,
-0.008295328356325626,
0.011419672518968582,
0.000902076717466116,
0.02731160819530487,
0.02532215043902397,
0.0036534189712256193,
-0.006789444014430046,
-0.010350758209824562,
-0.0119605278596282,
-0.019540246576070786,
-0.006306133233010769,
0.006119906902313232,
0.018565548583865166,
-0.025856755673885345,
-0.03442104160785675,
0.016791287809610367,
0.0038876112084835768,
0.041864633560180664,
0.003817768068984151,
-0.012719348073005676,
0.003178881946951151,
-0.0670412927865982,
0.01827887073159218,
-0.004571290221065283,
0.008593129925429821,
-0.0268489308655262,
0.0046848114579916,
0.005935510154813528,
0.033352747559547424,
0.03784346580505371,
0.020098615437746048,
-0.017392216250300407,
-0.0071856058202683926,
0.017384793609380722,
0.012201179750263691,
-0.0023924773558974266,
0.003939185291528702,
0.0013875662116333842,
-0.011881218291819096,
0.010267818346619606,
-0.020527061074972153,
-0.014042951166629791,
0.002720208838582039,
-0.012550562620162964,
0.00029512587934732437,
0.0016699465923011303,
-0.010418002493679523,
0.007983465678989887,
-0.00942571833729744,
-0.0019872463308274746,
-0.00768494326621294,
-0.01711273565888405,
-0.01479659229516983,
0.014076166786253452,
0.028895197436213493,
0.01468333788216114,
-0.015798665583133698,
0.02597850188612938,
0.019702907651662827,
-0.003268676809966564,
-0.02015865221619606,
0.01327353622764349,
-0.008330920711159706,
0.017117448151111603,
0.03471188619732857,
0.013123155571520329,
-0.007336833979934454,
0.01554526574909687,
-0.01293223537504673,
-0.009759226813912392,
0.009788701310753822,
0.008633553050458431,
0.005188248120248318,
0.03725714236497879,
0.00008154893293976784,
0.01685023494064808,
0.036990001797676086,
0.0018875161185860634,
-0.00584992952644825,
0.02714727818965912,
0.004927567671984434,
-0.019813012331724167,
0.007082279771566391,
0.013809585943818092,
-0.0025296718813478947,
0.00338956993073225,
-0.007453232072293758,
0.01324869878590107,
0.0239216648042202,
0.008853879757225513,
0.015509112738072872,
-0.003458871738985181,
-0.013551360927522182,
-0.009688194841146469,
0.0046811792999506,
-0.0182403065264225,
-0.00829142052680254,
0.006769619882106781,
0.0070512546226382256,
0.006381855811923742,
-0.008911242708563805,
-0.0017531642224639654,
0.015193086117506027,
0.0037083385977894068,
0.005587711930274963,
-0.00045534828677773476,
-0.002710999920964241,
0.01000386942178011,
-0.005235956981778145,
-0.02513779327273369,
0.01292055007070303,
-0.017516009509563446,
-0.012510512955486774,
0.0038871229626238346,
-0.002161170355975628,
0.0025700884871184826,
-0.020817868411540985,
-0.01646898314356804,
0.028285181149840355,
0.008457588031888008,
0.013646716251969337,
0.02095687761902809,
0.00023738853633403778,
-0.02048768848180771,
-0.0020363847725093365,
0.0022729430347681046,
-0.0010084710083901882,
0.0012146211229264736,
0.005634257569909096,
0.016533464193344116,
0.001998158637434244,
-0.0025121020153164864,
0.041716091334819794,
0.012064480222761631,
-0.006500598043203354,
0.0667208880186081,
-0.016077054664492607,
0.006191642489284277,
0.011405795812606812,
-0.013103684410452843,
0.008373269811272621,
-0.00396660016849637,
0.0028396896086633205,
0.002571968361735344,
-0.0029791402630507946,
-0.017798740416765213,
0.0356353297829628,
-0.021517805755138397,
0.013414887711405754,
0.0028171753510832787,
-0.004996698349714279,
0.0036990465596318245,
0.039367787539958954,
0.005770177114754915,
-0.004273947328329086,
0.0009802891872823238,
0.01457800343632698,
-0.006735072936862707,
-0.013672810047864914,
-0.02319083921611309,
-0.006402196362614632,
0.01667988859117031,
0.010434429161250591,
-0.030001968145370483,
-0.026592275127768517,
0.0011092375498265028,
0.02175908163189888,
-0.01647384651005268,
0.006252889521420002,
0.010039281100034714,
0.009323368780314922,
-0.002572320867329836,
0.011835591867566109,
0.010695594362914562,
-0.038594819605350494,
-0.01935962215065956,
0.002589685842394829,
-0.018113473430275917,
0.016553394496440887,
0.006695683114230633,
0.0038474686443805695,
-0.0026394487358629704,
-0.008910754695534706,
0.010116253048181534,
0.006457561161369085,
-0.004719073884189129,
-0.004403349943459034,
-0.022049400955438614,
-0.00960895698517561,
0.02147340588271618,
0.01123160868883133,
0.009358275681734085,
0.013167764991521835,
-0.0054288399405777454,
0.019620230421423912,
-0.012616253457963467,
-0.00038029206916689873,
-0.028273558244109154,
-0.021184049546718597,
0.0011468552984297276,
-0.00003147916868329048,
0.009905300103127956,
0.015203582122921944,
0.00012492015957832336,
0.02131858468055725,
-0.023852329701185226,
0.007010148372501135,
-0.003310281317681074,
-0.00019048317335546017,
0.027214938774704933,
0.024810124188661575,
0.032691482454538345,
-0.001315693836659193,
-0.030156977474689484,
0.023168504238128662,
0.026956915855407715,
0.010105498135089874,
0.005322564858943224,
-0.015953276306390762,
-0.008875811472535133,
-0.006589495576918125,
0.005297612398862839,
0.009125816635787487,
0.022966060787439346,
-0.015412626788020134,
0.009259391576051712,
0.008053647354245186,
-0.01162765733897686,
-0.0036826625000685453,
-0.08094687759876251,
-0.01043697539716959,
-0.02325120009481907,
0.02092173509299755,
0.005884315352886915,
0.02102276310324669,
0.0073788161389529705,
0.0015743928961455822,
0.0005358477355912328,
-0.017086420208215714,
0.0014779102057218552,
-0.008661128580570221,
-0.005333516281098127,
-0.011660192161798477,
-0.011349314823746681,
-0.013632146641612053,
0.00903476495295763,
0.000088896369561553,
0.002574448473751545,
-0.020294703543186188,
0.005893510766327381,
-0.010231776162981987,
-0.013258952647447586,
0.01520601287484169,
-0.013597061857581139,
-0.0038007088005542755,
-0.006501160562038422,
-0.002536097075790167,
-0.004809485748410225,
0.0019722869619727135,
0.010966961272060871,
0.01944798044860363,
0.015352379530668259,
-0.008083395659923553,
-0.010085245594382286,
-0.012374433688819408,
-0.014544633217155933,
-0.005038143135607243,
-0.006796893663704395,
-0.004272173158824444,
0.00782780721783638,
0.028745025396347046,
0.006621028296649456,
-0.007148743607103825,
-0.004289625212550163,
-0.009576703421771526,
-0.007630977779626846,
-0.020890899002552032,
0.02136024832725525,
-0.019035229459404945,
0.014015503227710724,
-0.0012429507914930582,
-0.011350243352353573,
0.008956322446465492,
-0.0167030468583107,
-0.010954405181109905,
-0.003568591782823205,
-0.003798740915954113,
-0.01570221781730652,
-0.009658217430114746,
-0.026209216564893723,
0.004679425619542599,
0.011610274203121662,
-0.0028136465698480606,
0.004207773134112358,
0.026307502761483192,
0.006715494208037853,
-0.029651867225766182,
-0.010392338037490845,
0.009418005123734474,
0.027571428567171097,
-0.015125188045203686,
0.004837460815906525,
-0.009707706980407238,
-0.008470149710774422,
0.007809320464730263,
-0.010590807534754276,
0.0056015863083302975,
-0.012449205853044987,
-0.007302979007363319,
0.0076724207028746605,
-0.003034159541130066,
-0.015376325696706772,
0.019033001735806465,
-0.03223193436861038,
-0.023383352905511856,
0.004142273683100939,
0.012272567488253117,
0.02285178005695343,
-0.019774816930294037,
0.005325343459844589,
0.016618283465504646,
-0.0017397865885868669,
0.009704860858619213,
0.007129949983209372,
0.002216629683971405,
-0.00894868467003107,
0.025128792971372604,
-0.007724751718342304,
0.011642360128462315,
-0.013766679912805557,
0.006016025319695473,
0.009210718795657158,
-0.0049391211941838264,
-0.0056120725348591805,
0.017282892018556595,
0.02479810267686844,
0.00366005627438426,
0.0034197447821497917,
-0.011737266555428505,
0.0027862563729286194,
-0.005579247605055571,
0.0002636415301822126,
0.015426087193191051,
0.01589365303516388,
0.018512990325689316,
0.013467417098581791,
-0.009567910805344582,
0.07233838737010956,
0.009234825149178505,
0.001821022480726242,
0.002220751252025366,
0.011230054311454296,
-0.015295776538550854,
-0.043901655822992325,
-0.00575981056317687,
0.015599409118294716,
-0.0017432686872780323,
0.011819406412541866,
-0.004429791122674942,
0.02381204441189766,
0.00268498994410038,
0.032466620206832886,
-0.02711247280240059,
-0.002111627021804452,
0.03338775783777237,
-0.03988178074359894,
-3.3061951398849487e-7,
0.0031443070620298386,
0.0054280515760183334,
-0.005135164596140385,
-0.010590318590402603,
-0.0074508413672447205,
-0.039043936878442764,
-0.009390469640493393,
-0.014550784602761269,
-0.03461272269487381,
0.0025717499665915966,
0.014338836073875427,
-0.018033944070339203,
-0.0025610465090721846,
0.014205912128090858,
-0.00014268513768911362,
-0.010855568572878838,
-0.029686877503991127,
-0.019510559737682343,
0.010432985611259937,
-0.010907724499702454,
-0.00531808752566576,
-0.010198965668678284,
-0.007603656500577927,
0.015921659767627716,
0.015362467616796494,
-0.00592158455401659,
0.020484885200858116,
-0.001070651924237609,
-0.01569388620555401,
-0.00040200247894972563,
-0.023719994351267815,
0.007472119759768248,
0.008264477364718914,
0.018572019413113594,
-0.011906137689948082,
-0.004783775191754103,
0.0016224011778831482,
-0.02450978383421898,
-0.015452573075890541,
0.0008364825043827295,
-0.0014525812584906816,
-0.02126842737197876,
0.005190912634134293,
-0.006418177392333746,
0.004956543445587158,
-0.013293756172060966,
-0.013232206925749779,
-0.007820719853043556,
-0.03275991976261139,
0.005090936552733183,
0.016793973743915558,
0.018602803349494934,
-0.006916480138897896,
-0.010723843239247799,
-0.041300639510154724,
0.012497944757342339,
0.02521486207842827,
-0.018966324627399445,
-0.001228246372193098,
-0.003888577688485384,
0.026021365076303482,
0.005526552442461252,
-0.004364411346614361,
-0.030653879046440125,
-0.0026626409962773323,
-0.017740003764629364,
-0.0160248763859272,
-0.07423277199268341,
-0.017645977437496185,
0.014751752838492393,
-0.009887033142149448,
-0.019317690283060074,
0.027316544204950333,
-0.008299161680042744,
-0.017075814306735992,
0.011142589151859283,
-0.010003210976719856,
-0.02310299687087536,
0.004580098204314709,
-0.0003167940303683281,
-0.010703019797801971,
0.015984080731868744,
-0.012967788614332676,
-0.005494019016623497,
0.00019864726345986128,
-0.0038711614906787872,
0.01649029180407524,
0.01359420083463192,
0.005794167518615723,
0.0006952520925551653,
0.0022433935664594173,
-0.003397588850930333,
-0.08135449886322021,
0.00028457818552851677,
0.007538261823356152,
-0.014696565456688404,
-0.00503414636477828,
-0.01889125257730484,
0.004793614149093628,
0.0031872515100985765,
-0.014680549502372742,
-0.021072331815958023,
0.006857436150312424,
-0.00960242748260498,
0.029951542615890503,
0.004849227145314217,
0.0063088503666222095,
-0.005389089230448008,
0.015690026804804802,
0.0008445628918707371,
0.008610294200479984,
-0.02722633257508278,
-0.007894344627857208,
-0.00599724892526865,
-0.011236926540732384,
0.0071320319548249245,
-0.0017729485407471657,
-0.004701768979430199,
-0.026965919882059097,
0.008075661957263947,
0.02183178998529911,
-0.023962033912539482,
0.0013007874367758632,
0.007266131695359945,
-0.009667808189988136,
0.008882736787199974,
-0.020754855126142502,
-0.009642470628023148,
-0.020604321733117104,
0.0002940259873867035,
0.004887267481535673,
0.011363551951944828,
-0.0002707767707761377,
0.07222777605056763,
-0.009435135871171951,
0.0042787399142980576,
-0.019845614209771156,
-0.032351795583963394,
0.006914705038070679,
-0.014258019626140594,
0.0028749776538461447,
0.020257841795682907,
0.0026668310165405273,
-0.009402279742062092,
0.022036410868167877,
-0.0017731585539877415,
0.025140680372714996,
0.00689849816262722,
-0.002577850129455328,
-0.0034050894901156425,
0.01845681667327881,
0.00846464466303587,
-0.00919392704963684,
0.010019004344940186,
0.011578155681490898,
0.07180324196815491,
-0.033248309046030045,
-0.0013584110420197248,
-0.01754879206418991,
-0.0022396801505237818,
0.004105082713067532,
0.004951295908540487,
-0.017366083338856697,
-0.003271315945312381,
-0.014718892052769661,
0.024820566177368164,
-0.011148205026984215,
0.014337575063109398,
0.006478723604232073,
-0.027916595339775085,
-0.006595713552087545,
-0.01778026856482029,
0.013997921720147133,
-0.03384636715054512,
-0.0006927484646439552,
0.023078501224517822,
0.019072523340582848,
-0.020623432472348213,
0.016802679747343063,
-0.0008027493022382259,
0.0045685297809541225,
0.013505018316209316,
0.020378971472382545,
-0.003044913988560438,
-0.0010844178032130003,
-0.01242045871913433,
-0.010371288284659386,
0.008459007367491722,
0.007868839427828789,
0.017715230584144592,
0.019466858357191086,
-0.014867560938000679,
-0.0008705099462531507,
-0.0007005925290286541,
-0.006057692691683769,
-0.032109759747982025,
0.0034132632426917553,
0.004104787949472666,
0.023355470970273018,
0.02818700671195984,
-0.005274109076708555,
0.02039632946252823,
-0.03563995286822319,
-0.020588688552379608,
0.013341055251657963,
-0.03575845807790756,
0.007101648952811956,
0.017739132046699524,
-0.014363673515617847,
0.031221389770507812,
0.01899545080959797,
-0.014261534437537193,
0.020063135772943497,
-0.03300163522362709,
-0.04168548062443733,
0.0011765153612941504,
-0.019607188180088997,
0.006026026792824268,
-0.0093112513422966,
-0.025606807321310043,
-0.01883538067340851,
0.021953638643026352,
-0.01402086392045021,
-0.01066674292087555,
0.015839779749512672,
0.006129731424152851,
-0.0015975073911249638,
0.0066575356759130955,
-0.0057562910951673985,
-0.02646612748503685,
0.011987888254225254,
-0.002056400291621685,
-0.006733817979693413,
0.012579729780554771,
0.01602860912680626,
-0.004508981015533209,
0.0005391370505094528,
0.013245281763374805,
-0.018443483859300613,
0.008460447192192078,
0.008646322414278984,
-0.02800656110048294,
-0.008944433182477951,
-0.01679815724492073,
0.008791469037532806,
0.013667440041899681,
0.006176243536174297,
-0.0005526760360226035,
0.01914665475487709,
0.012306046672165394,
0.033951133489608765,
0.014791262336075306,
0.008450538851320744,
-0.03431481495499611,
-0.0014079257380217314,
0.021456550806760788,
0.025347251445055008,
-0.0154409259557724,
-0.001082791481167078,
0.0017515788786113262,
-0.006037469021975994,
-0.025213871151208878,
0.0362074188888073,
0.005701531656086445,
0.033700741827487946,
-0.028162021189928055,
-0.006764254532754421,
0.017349157482385635,
0.0007677762769162655,
-0.0064927684143185616,
0.007093541324138641,
-0.011552784591913223,
0.031721435487270355,
0.006499437149614096,
-0.010768469423055649,
0.011650042608380318,
-0.0025315626990050077,
0.029600873589515686,
0.0014176320983096957,
-0.013031840324401855,
-0.03008401021361351,
-0.0019511239370331168,
-0.00091969920322299,
-0.007798478007316589,
-0.013940864242613316,
0.0057072993367910385,
-0.03411165252327919,
0.022388216108083725,
-0.0025720710400491953,
0.012675965204834938,
0.006015656515955925,
0.020967423915863037,
-0.01632174663245678,
-0.014781405217945576,
0.030213896185159683,
-0.015274692326784134,
-0.017260000109672546,
0.006029936484992504,
0.004431046545505524,
0.01146537996828556,
-0.002756380243226886,
0.01733178086578846,
-0.025515221059322357,
0.010318181477487087,
-0.010961170308291912,
-0.005710897967219353,
-0.0016137408092617989,
0.0012386939488351345,
-0.007673592306673527,
-0.01756928861141205,
0.022210001945495605,
0.0012474278919398785,
-0.0017221495509147644,
-0.034564726054668427,
-0.012542483396828175,
-0.017662063241004944,
-0.0006770631298422813,
-0.015125948004424572,
-0.00798823032528162,
-0.006601753644645214,
0.024357885122299194,
0.020421063527464867,
0.01969638466835022,
0.004133929032832384,
-0.007035309914499521,
0.03386007249355316,
0.0027850891929119825,
-0.020793568342924118,
0.02583307772874832,
0.0019188569858670235,
-0.014586064033210278,
0.014748785644769669,
-0.00930735096335411,
-0.024305399507284164,
-0.0034099360927939415,
0.004287733696401119,
-0.013328221626579762,
-0.009850140661001205,
-0.011121928691864014,
-0.0015593725256621838,
-0.007407264318317175,
0.004294863902032375,
-0.03164616599678993,
0.00309902336448431,
0.034762755036354065,
-0.006706641986966133,
-0.010089745745062828,
-0.004766340833157301,
-0.011901688762009144,
-0.0006625745445489883,
0.010356713086366653,
0.010374152101576328,
-0.00215329322963953,
-0.0006028381176292896,
-0.024220967665314674,
-0.011844025924801826,
-0.01915903203189373
] | [
-0.183820441365242,
0.11728543043136597,
0.5386495590209961,
0.3443223536014557,
-0.36460933089256287,
0.6826221942901611,
0.26431798934936523,
0.5645283460617065,
-0.6933240294456482,
-0.9683285355567932,
-0.11496447026729584,
0.7206059694290161,
0.1471196711063385,
0.09745947271585464,
-0.32240527868270874,
0.6401999592781067,
0.8399018049240112,
0.0460265651345253,
-0.7622108459472656,
-0.116417795419693,
0.1294490396976471,
-0.41799303889274597,
0.6757839322090149,
-0.07365799695253372,
0.21905511617660522,
-0.2441476434469223,
0.04855143651366234,
0.2799064815044403,
0.31193244457244873,
0.06333920359611511,
-0.4273330867290497,
0.40485259890556335,
0.04813181608915329,
-0.05336616188287735,
-0.07614003866910934,
0.19078631699085236,
-0.5495527982711792,
-0.5637729167938232,
0.1216706782579422,
-0.06175679713487625,
0.12376688420772552,
0.11282261461019516,
-0.6804023385047913,
0.17456892132759094,
-0.5121983289718628,
-0.39232754707336426,
-1.152382254600525,
0.7732433080673218,
-0.029771625995635986,
0.3703307807445526,
-0.6792765259742737,
0.22174353897571564,
0.3030112087726593,
0.31830793619155884,
0.03698635846376419,
-0.04212036728858948,
-0.3841516971588135,
0.09207507222890854,
-0.11018921434879303,
-0.5472413897514343,
0.3299390375614166,
0.2179981768131256,
-0.14499042928218842,
-0.012559586204588413,
-0.46365150809288025,
-0.22106505930423737,
0.068427175283432,
0.0019318890990689397,
-1.0025267601013184,
-0.03946170583367348,
-0.2684169411659241,
-0.4322282373905182,
0.08921322226524353,
0.4081883728504181,
-0.6961631178855896,
-0.017373213544487953,
0.29616817831993103,
-0.3660069406032562,
0.15011678636074066,
0.0005261240294203162,
0.2533557713031769,
0.1364637315273285,
0.6391941905021667,
0.18689200282096863,
-0.17775316536426544,
0.07602780312299728,
-0.523622453212738,
0.10113053023815155,
-0.22285906970500946,
-0.522747814655304,
-0.061514437198638916,
-0.28345853090286255,
0.16308079659938812,
0.3520170748233795,
0.30825111269950867,
0.4856165945529938,
1.0443131923675537,
-0.38967281579971313,
-0.043373383581638336,
-0.015039925463497639,
0.30012762546539307,
0.02281615510582924,
0.6690891981124878,
0.2259923666715622,
-0.18814200162887573,
-0.8394935727119446,
0.3971821665763855,
-0.59124356508255,
-0.33947882056236267,
0.03171295300126076,
-0.9729084968566895,
-0.13911715149879456,
-0.15371984243392944,
-0.4294011890888214,
-0.09181979298591614,
0.20736101269721985,
0.047046661376953125,
-0.09308107942342758,
-0.08243275433778763,
-0.39069196581840515,
-0.14184677600860596,
0.3203188478946686,
-0.18300338089466095,
-0.18218113481998444,
-0.04682251438498497,
-0.2720774710178375,
0.19183097779750824,
-0.10265728086233139,
-0.25168171525001526,
-0.3891664743423462,
0.05315954610705376,
0.4256073534488678,
0.17641571164131165,
-0.2811639904975891,
0.2676769495010376,
0.0042180754244327545,
0.41239097714424133,
0.183250293135643,
0.1947825700044632,
-0.25597646832466125,
-0.1553410440683365,
-1.0590837001800537,
-0.9155681729316711,
-0.5797012448310852,
0.21452943980693817,
-0.9188352227210999,
-0.09921245276927948,
0.03203408047556877,
-0.3488197922706604,
-0.5561966896057129,
-0.27136707305908203,
0.2231535166501999,
-0.15380270779132843,
-0.3225771486759186,
0.40514084696769714,
0.4909038543701172,
0.03868371620774269,
-0.46002817153930664,
0.4834384620189667,
0.1260499805212021,
0.42672646045684814,
-0.41406428813934326,
-0.10831104964017868,
-0.5782366991043091,
-0.251335084438324,
-0.12550070881843567,
0.688530445098877,
-0.03551803529262543,
-0.13848073780536652,
0.03492649272084236,
-0.4141540825366974,
-0.2190820425748825,
0.5907813310623169,
0.010647737421095371,
-0.0017248596996068954,
-0.18745772540569305,
0.49385344982147217,
0.516634464263916,
0.6977496147155762,
0.06603218615055084,
-0.6731314063072205,
-0.04333721473813057,
0.19611236453056335,
-0.13703149557113647,
-0.04953274875879288,
-0.22504958510398865,
0.5142949223518372,
-0.3886919319629669,
-0.518243134021759,
-0.18107594549655914,
0.4290625751018524,
-0.6893675327301025,
0.18720091879367828,
-0.014980052597820759,
1.2642412185668945,
0.05070066824555397,
-0.3428013026714325,
0.33482205867767334,
-0.10311361402273178,
0.7853454947471619,
-0.2987412214279175,
-0.4480690658092499,
0.4560771882534027,
-0.1751788854598999,
-0.6868323087692261,
-0.0723433643579483,
-0.08755198866128922,
-0.1778113842010498,
-0.34955814480781555,
0.03305951505899429,
0.4046868681907654,
-0.9922158718109131,
-0.5651851892471313,
-0.05721047893166542,
0.6798973679542542,
0.021392539143562317,
-0.20569226145744324,
-0.23187397420406342,
-0.5415278077125549,
-0.39571332931518555,
0.39857375621795654,
-0.5641654133796692,
0.48503562808036804,
0.26123082637786865,
-0.0697987973690033,
0.7786151170730591,
0.500811755657196,
0.4672544002532959,
0.8522499203681946,
-0.7815754413604736,
0.10869894921779633,
-0.20670439302921295,
0.21101409196853638,
-0.1909855455160141,
-0.45205557346343994,
0.031586986035108566,
0.17340537905693054,
-0.2929524779319763,
0.4900363087654114,
-0.3533070385456085,
-0.20606568455696106,
-0.27915889024734497,
-0.6749082207679749,
-0.021524464711546898,
0.25674307346343994,
-0.5570369362831116,
-0.3012065291404724,
0.4133661985397339,
-0.6045806407928467,
0.048139773309230804,
-0.2610534131526947,
0.9737963676452637,
0.1586596518754959,
-0.6209812760353088,
0.2500218451023102,
0.055455680936574936,
0.8680922389030457,
-0.013464439660310745,
0.13140825927257538,
-0.2671421468257904,
-0.5222086906433105,
0.45114845037460327,
-0.1034194678068161,
-0.5156614184379578,
-0.6086055636405945,
-0.5057814717292786,
-0.23032402992248535,
-0.24010267853736877,
0.013549180701375008,
0.2990196645259857,
0.27202415466308594,
0.01190253533422947,
-0.07045033574104309,
0.0698990598320961,
-0.0965045616030693,
-0.23385335505008698,
0.19551371037960052,
-0.05895627662539482,
-0.5592832565307617,
-0.5655461549758911,
-0.04663176089525223,
0.8398211002349854,
0.9013445377349854,
0.003962333779782057,
-0.5775225758552551,
-0.005106394644826651,
-0.05020719766616821,
-0.4640405774116516,
-0.3147364854812622,
-0.15612497925758362,
-0.24937833845615387,
0.3254234194755554,
0.4056817591190338,
-0.06663207709789276,
0.00009696446068119258,
0.40248262882232666,
0.14648915827274323,
0.10530257225036621,
0.19648556411266327,
-0.35891440510749817,
-0.6102136969566345,
0.370572954416275,
0.10489365458488464,
-0.3930094540119171,
-0.1066100001335144,
0.011473803780972958,
-0.3094264566898346,
0.9936636686325073,
-5.729783535003662,
-0.4961507320404053,
-0.3138558268547058,
-0.40625879168510437,
0.09050171822309494,
0.2643784284591675,
0.28453928232192993,
-0.07376479357481003,
0.12305043637752533,
-0.012471094727516174,
0.5943944454193115,
0.2012035846710205,
0.044013217091560364,
0.2627016603946686,
-0.19064085185527802,
-0.23224204778671265,
-0.11374297738075256,
-0.015497208572924137,
-0.1537323147058487,
0.2646733522415161,
0.6083728671073914,
-0.37383535504341125,
-0.3851235806941986,
0.5266177654266357,
0.14531740546226501,
0.506826639175415,
-0.21926404535770416,
-0.20423322916030884,
-0.4759674072265625,
-0.31081098318099976,
-0.0004646242887247354,
-0.09095308184623718,
-0.2702086567878723,
0.08984220027923584,
1.0002084970474243,
0.1690274327993393,
0.16659507155418396,
0.18161222338676453,
0.22896930575370789,
-0.1557183712720871,
0.18808327615261078,
-0.29727795720100403,
0.41050976514816284,
-0.5226537585258484,
0.7278760075569153,
-0.13210664689540863,
-0.4592793583869934,
-0.0827523022890091,
-0.32126933336257935,
0.4320996403694153,
0.23503008484840393,
-0.10369156301021576,
-0.3085009753704071,
0.6145566701889038,
0.7016947865486145,
0.13122962415218353,
0.5145524740219116,
0.3271027207374573,
-0.13564646244049072,
-0.20041482150554657,
0.22617529332637787,
-0.10565652698278427,
-0.5197166800498962,
-0.8673568964004517,
-0.26726600527763367,
0.14297877252101898,
-0.6003842353820801,
-0.17245075106620789,
0.540842592716217,
0.27191194891929626,
-0.11373855918645859,
0.2868148684501648,
0.01682555489242077,
-0.6321600079536438,
-0.14994291961193085,
-0.1421874612569809,
-0.06709647178649902,
0.16926030814647675,
-0.45965275168418884,
0.045567434281110764,
-0.30195993185043335,
-0.05927208065986633,
0.042038772255182266,
-0.27094945311546326,
-0.2561083137989044,
-0.301971971988678,
-0.3265356719493866,
0.34714341163635254,
0.19305042922496796,
0.6926611065864563,
0.27132466435432434,
-0.3926357924938202,
0.10226401686668396,
0.44727858901023865,
0.20997264981269836,
0.13527312874794006,
0.5706535577774048,
0.6613709330558777,
0.527853786945343,
-0.28490063548088074,
1.0024341344833374,
-0.17981447279453278,
-0.40134134888648987,
-0.1923111379146576,
-0.4149870276451111,
0.3362206816673279,
-0.2620311975479126,
0.1969253122806549,
1.1359256505966187,
-0.4713444411754608,
0.0035991882905364037,
-0.15715862810611725,
0.15363448858261108,
-0.663286030292511,
0.6039900779724121,
-0.6030753254890442,
-0.3764915466308594,
0.357572466135025,
0.5804142355918884,
-0.42989832162857056,
-0.05568511784076691,
0.457141637802124,
-0.9118515849113464,
0.41856956481933594,
0.2225998491048813,
0.24728794395923615,
-0.129876971244812,
0.4551704227924347,
-0.5106483697891235,
0.36560097336769104,
0.6326489448547363,
0.21633999049663544,
0.24488194286823273,
0.777878999710083,
0.03771261125802994,
-0.7686623334884644,
0.6376858353614807,
0.49978873133659363,
0.09443242102861404,
-0.6414498090744019,
0.9180205464363098,
0.2330016791820526,
-0.23581954836845398,
-0.5076927542686462,
-0.0954841673374176,
0.23449155688285828,
-1.0055207014083862,
0.13570278882980347,
-0.35503238439559937,
0.13250772655010223,
-0.11628369987010956,
0.10933659970760345,
-0.4685807526111603,
0.602995753288269,
0.2040204405784607,
0.029475901275873184,
-0.009210203774273396,
0.2697790861129761,
-0.08649782836437225,
-0.2103896290063858,
0.03882550820708275,
-0.41161486506462097,
-0.5483195781707764,
-0.369606077671051,
-0.2078515589237213,
0.4762047231197357,
-0.48031988739967346,
-0.6385434865951538,
0.3942282497882843,
0.6214969158172607,
0.14072847366333008,
-0.10119305551052094,
-0.15899786353111267,
-0.28357258439064026,
0.4257086515426636,
-0.4845377802848816,
0.17873406410217285,
0.04805774614214897,
0.1744840145111084,
0.5949180722236633,
0.22013932466506958,
-0.3485621511936188,
0.37699469923973083,
0.07840295881032944,
0.2851330041885376,
0.27056652307510376,
-0.1112491562962532,
-0.015873467549681664,
-0.28811371326446533,
-0.5326829552650452,
-0.024602243676781654,
0.10457765311002731,
-0.4115639925003052,
-0.00039327333797700703,
0.6679513454437256,
0.29021814465522766,
-0.16509248316287994,
-0.010658436454832554,
-0.3469233512878418,
-0.2682833969593048,
0.2807517349720001,
0.5959653854370117,
-0.36706167459487915,
0.3762083053588867,
1.0140049457550049,
-0.4305996894836426,
0.4098215699195862,
-0.14526799321174622,
-0.5765983462333679,
0.3105989694595337,
-0.7285240292549133,
-0.10003094375133514,
-0.5043455362319946,
0.15558047592639923,
-0.33958157896995544,
0.0811641663312912,
0.28932687640190125,
-0.5860569477081299,
-0.08937090635299683,
0.5990203022956848,
0.0947037935256958,
-0.016928495839238167,
-0.07777776569128036,
-0.1190493106842041,
-0.07018756866455078,
0.08844566345214844,
0.09659045189619064,
-0.7105218768119812,
0.4878550171852112,
-0.19132906198501587,
0.09743262082338333,
0.019866373389959335,
-0.09661409258842468,
0.33244073390960693,
0.1257658451795578,
-0.9957842230796814,
0.13187925517559052,
0.36172518134117126,
-0.1845466047525406,
0.47354423999786377,
0.8804033398628235,
0.9956794381141663,
-0.491994172334671,
0.27146613597869873,
0.07005162537097931,
0.09090251475572586,
0.4467145502567291,
-0.6011126041412354,
-0.4416377544403076,
0.24355515837669373,
0.43097981810569763,
-0.5211576223373413,
0.16925133764743805,
0.23371005058288574,
0.534669816493988,
-0.3905068635940552,
-0.046223368495702744,
-0.8318782448768616,
-0.15740202367305756,
0.46645379066467285,
0.038781505078077316,
-0.4447077214717865,
0.11516033113002777,
-0.1890830099582672,
0.4423757791519165,
0.13015523552894592,
-0.6845411658287048,
-0.08236180245876312,
0.8248705863952637,
-0.2216516137123108,
0.6843149065971375,
0.23059052228927612,
0.06337355077266693,
-0.1843389868736267,
-0.10695182532072067,
-0.03990987315773964,
-0.2623022794723511,
0.16961538791656494,
0.48878487944602966,
-0.07814349234104156,
0.33929741382598877,
-0.049456097185611725,
0.31716418266296387,
-0.6436637043952942,
0.3618607223033905,
-0.5765584707260132,
0.19766567647457123,
-0.08290092647075653,
-0.13038107752799988,
-0.04405052959918976,
-0.2204774022102356,
-0.08080336451530457,
-0.03713570907711983,
0.07270977646112442,
0.33381521701812744,
-0.0030941192526370287,
0.4743867814540863,
0.6868013143539429,
-0.08305160701274872,
0.23206938803195953,
-0.5120487213134766,
0.4163840413093567,
-0.38394883275032043,
-0.43983060121536255,
0.5616204738616943,
-0.06151280179619789,
0.1860363632440567,
-0.24612145125865936,
-0.36846214532852173,
-0.3534858524799347,
0.3073157072067261,
-0.10346006602048874,
0.5798119306564331,
0.7910294532775879,
-0.1542993187904358,
0.1244368776679039,
0.5196343660354614,
0.06916503608226776,
0.18292266130447388,
0.2937334179878235,
-0.20760992169380188,
0.7472217082977295,
0.22508662939071655,
-0.12026361376047134,
-0.1344849020242691,
0.3972080647945404,
-0.04921061918139458,
0.10804883390665054,
0.42946872115135193,
0.6485638618469238,
0.3184314966201782,
0.27368277311325073,
-0.1655047982931137,
1.0342750549316406,
0.2823849320411682,
-0.44222691655158997,
0.44147124886512756,
-0.5014874339103699,
-0.27700570225715637,
0.14296743273735046,
0.9998887181282043,
-0.05302583798766136,
-0.36060887575149536,
0.38740405440330505,
-0.16790226101875305,
0.5652886629104614,
0.08506909012794495,
0.16630084812641144,
-0.09361633658409119,
0.21675942838191986,
0.3438703119754791,
-0.733221173286438,
0.010390889830887318,
0.3838821053504944,
0.10684749484062195,
0.13719257712364197,
0.17445777356624603,
-0.6673181653022766,
-0.6229868531227112,
0.21377472579479218,
-0.3437129259109497,
0.6384163498878479,
0.055010177195072174,
0.03222716227173805,
-0.04622035101056099,
0.11946018040180206,
0.3691021502017975,
0.0004741739248856902,
0.09901335835456848,
-0.40273934602737427,
-0.5227647423744202,
0.5063730478286743,
-0.1522483080625534,
-0.22131440043449402,
0.3599819839000702,
-0.18474873900413513,
0.6614657044410706,
-0.11091092228889465,
-0.0827631801366806,
-0.43918275833129883,
-0.0609959177672863,
-0.6008327007293701,
-0.35152459144592285,
-0.8879110813140869,
-0.0035060830414295197,
0.14246273040771484,
0.29374170303344727,
0.06662650406360626,
0.23968075215816498,
-0.04357259348034859,
-0.0391046479344368,
-0.5462876558303833,
0.1798298954963684,
-0.20885007083415985,
0.023350585252046585,
-0.5818004012107849,
-0.3576904535293579,
0.2373117357492447,
0.3540307283401489,
0.19343307614326477,
0.3208305835723877,
0.007780971005558968,
-0.3635946810245514,
0.27954307198524475,
-0.6316279768943787,
0.016573591157794,
0.08679115027189255,
-0.6171292066574097,
-0.9692389965057373,
0.05012206733226776,
0.2192767858505249,
0.14740914106369019,
-0.330645889043808,
0.40424221754074097,
0.07762294262647629,
0.1465902477502823,
0.4679598808288574,
-0.46122118830680847,
0.03806927055120468,
-0.8824130892753601,
0.15456610918045044,
0.06914134323596954,
1.1377921104431152,
0.120090052485466,
0.20418594777584076,
-0.11382895708084106,
0.5077105164527893,
0.15147051215171814,
-0.36474189162254333,
0.22496774792671204,
-0.8200370669364929,
0.3174198865890503,
-0.5447234511375427,
0.15128450095653534,
-0.42275315523147583,
0.05204574018716812,
0.5400935411453247,
-0.147421732544899,
-0.061835091561079025,
-0.3793065547943115,
0.06897515058517456,
-0.5729497075080872,
0.08906155079603195,
0.35070812702178955,
-0.3188944160938263,
-0.13414013385772705,
-0.275687038898468,
-0.620970606803894,
-0.0585356242954731,
0.4572734236717224,
0.06093417480587959,
-0.16508688032627106,
0.3919408917427063,
-0.30508437752723694,
-0.316258043050766,
0.15441082417964935,
0.24265402555465698,
-0.3704324960708618,
-0.18210744857788086,
0.29826614260673523
] |
Cytosine arabinoside (ara-C) is widely used for the treatment of leukemias and displays significant toxicities. Lovastatin, an HMG-CoA reductase inhibitor, is extensively used to treat hypercholesterolemia. To determine whether lovastatin could augment ara-C's activity we have examined their effects in the human erythroleukemia K562 cell line and the ara-C resistant ARAC8D cell line. A synergistic interaction between the two drugs was found. We have demonstrated that the interaction does not occur at the level of RAS but may involve lovastatin's effect of downregulating MAPK activity and preventing ara-C-induced MAPK activation. These studies represent the first description of a potentially beneficial interaction between lovastatin and ara-C that could be applied to the treatment of human leukemia. | [
0.0064743575640022755,
0.0017372752772644162,
-0.022762712091207504,
0.004834206774830818,
0.01649477332830429,
0.01467040739953518,
0.009948693215847015,
-0.013743214309215546,
-0.012116131372749805,
0.0047149257734417915,
-0.004559190943837166,
0.0006897538551129401,
-0.005514691583812237,
0.028992172330617905,
-0.017135143280029297,
0.002256997860968113,
-0.012918484397232533,
0.02442147396504879,
0.012253012508153915,
0.023975268006324768,
-0.006007349118590355,
-0.017732474952936172,
0.009367396123707294,
0.0029561840929090977,
0.015331398695707321,
0.03236803784966469,
-0.012015411630272865,
-0.008764627389609814,
-0.0052223773673176765,
-0.03722871467471123,
0.004704474471509457,
-0.017675917595624924,
-0.0038906631525605917,
0.006799251772463322,
-0.022168884053826332,
-0.004185814410448074,
-0.006469522602856159,
0.02541946992278099,
0.009627326391637325,
-0.003905222285538912,
-0.005505017936229706,
-0.004181147087365389,
0.002298656851053238,
-0.002249857410788536,
-0.004741106182336807,
-0.00404699519276619,
-0.005260178353637457,
0.00995493121445179,
0.02493199147284031,
0.008620169945061207,
-0.0037974449805915356,
-0.01919606514275074,
-0.014460011385381222,
0.002981389407068491,
-0.005779174156486988,
-0.0008950168266892433,
0.01572592929005623,
-0.01083553396165371,
-0.017717838287353516,
0.025783345103263855,
0.0060007162392139435,
-0.01554809045046568,
-0.01765318587422371,
0.0018997836159542203,
-0.005475766956806183,
-0.06696239113807678,
-0.008840884082019329,
-0.010230368934571743,
0.014353455975651741,
0.0051498920656740665,
-0.03141070157289505,
0.017077140510082245,
0.013174702413380146,
0.016155622899532318,
-0.01733524724841118,
-0.006791218183934689,
0.008028066717088223,
-0.008292315527796745,
0.00724015710875392,
-0.0063045211136341095,
-0.003197457641363144,
0.0044841342605650425,
-0.01205483265221119,
0.006483036559075117,
0.007905339822173119,
-0.025269396603107452,
-0.014540084637701511,
-0.01526902336627245,
0.01853228360414505,
-0.03217267245054245,
0.0011133169755339622,
0.005155281163752079,
-0.0292012020945549,
-0.01487058773636818,
-0.03567691892385483,
-0.00667954795062542,
-0.005327831953763962,
-0.015241607092320919,
-0.009297851473093033,
-0.014903118833899498,
-0.014741044491529465,
-0.005997163243591785,
0.008970413357019424,
-0.018839819356799126,
-0.01590062491595745,
0.012207085266709328,
0.0095934197306633,
-0.020499475300312042,
0.011965752579271793,
0.013912318274378777,
-0.013032909482717514,
0.020809663459658623,
0.009472806937992573,
-0.0007036421447992325,
-0.002281688619405031,
0.019802726805210114,
-0.0067290496081113815,
-0.015122788026928902,
0.01007632166147232,
-0.024193497374653816,
-0.015158195048570633,
-0.010537205263972282,
0.00788844283670187,
-0.02736189216375351,
0.0023606016766279936,
-0.00582006573677063,
0.010660691186785698,
0.009973552078008652,
-0.0017465273849666119,
-0.0003003739984706044,
-0.006016026251018047,
0.01073494739830494,
-0.020685477182269096,
-0.023621950298547745,
-0.005880772136151791,
0.0028548906557261944,
0.01182432658970356,
-0.012898066081106663,
-0.010079440660774708,
-0.0022077481262385845,
-0.020829182118177414,
0.00597925903275609,
0.0017214546678587794,
0.009157711640000343,
0.01872032880783081,
-0.02120441012084484,
0.01307598315179348,
0.013854455202817917,
0.034147344529628754,
0.002636959310621023,
0.0033196231815963984,
-0.008123277686536312,
-0.019005287438631058,
-0.0027088825590908527,
-0.0026779575273394585,
0.005108834709972143,
-0.00828937254846096,
0.006956364493817091,
-0.005955255590379238,
0.02068212814629078,
-0.0034478025045245886,
-0.041515953838825226,
0.009620401076972485,
0.010033787228167057,
0.035149089992046356,
0.016422392800450325,
-0.0034005315974354744,
-0.007814750075340271,
-0.01595153659582138,
0.007504582405090332,
-0.015467489138245583,
0.023846320807933807,
0.006030455231666565,
0.006368638947606087,
-0.016672346740961075,
-0.0004021379863843322,
-0.00962142925709486,
0.0065180049277842045,
-0.010084215551614761,
0.06609885394573212,
-0.016224749386310577,
0.010192645713686943,
0.004917055368423462,
-0.005228147841989994,
0.007554853335022926,
-0.024104252457618713,
0.01695212908089161,
0.0003619900671765208,
-0.007145981770008802,
-0.022628970444202423,
0.009546499699354172,
-0.004317827522754669,
-0.021288616582751274,
-0.006767337676137686,
-0.01896301656961441,
0.0023255902342498302,
0.0034242926631122828,
0.019236505031585693,
0.011593620292842388,
0.011974839493632317,
-0.004724808037281036,
0.01033899374306202,
0.019377879798412323,
-0.01616547256708145,
-0.011734932661056519,
-0.0024258459452539682,
-0.0033402612898498774,
-0.014172481372952461,
-0.022173769772052765,
-0.0027197811286896467,
0.026115931570529938,
0.029357004910707474,
-0.008018145337700844,
0.0052872016094625,
0.010837476700544357,
0.01114443689584732,
-0.009080826304852962,
0.007485231384634972,
0.005066944286227226,
-0.00993216224014759,
-0.0018293437315151095,
-0.0028207367286086082,
-0.015158112160861492,
0.009249595925211906,
0.008162451907992363,
-0.0070068626664578915,
0.013519362546503544,
0.010104629211127758,
0.018389105796813965,
0.007262581028044224,
-0.012194297276437283,
-0.01860775426030159,
-0.013713542371988297,
0.015106070786714554,
-0.010565363802015781,
-0.0074846684001386166,
0.01249554380774498,
-0.017860587686300278,
0.014339195564389229,
-0.012603182345628738,
0.006537093780934811,
0.0017585547175258398,
0.005711488891392946,
0.020542290061712265,
-0.00539027526974678,
-0.015424486249685287,
0.027261883020401,
-0.0004510744474828243,
-0.019094549119472504,
-0.0279618538916111,
0.007062569726258516,
0.0032375557348132133,
-0.012135231867432594,
0.02301904931664467,
-0.010479763150215149,
-0.0008221794851124287,
-0.005991925019770861,
0.0040687453001737595,
0.024516897276043892,
0.00919155403971672,
-0.00027633714489638805,
0.001590124098584056,
-0.0073287710547447205,
-0.026650287210941315,
-0.0053145550191402435,
0.039333269000053406,
0.02118692733347416,
0.01963729038834572,
0.018425799906253815,
-0.004629871807992458,
0.009397036395967007,
0.005832665599882603,
-0.009807253256440163,
-0.08203154057264328,
-0.012661236338317394,
0.0015674051828682423,
0.004925251938402653,
0.005460226442664862,
0.02780330367386341,
-0.018355827778577805,
0.0073624784126877785,
0.0012614455772563815,
0.0049506365321576595,
0.0235421285033226,
-0.003188297851011157,
0.0027044937014579773,
-0.007754496298730373,
-0.0003517457516863942,
-0.004586647264659405,
0.005735529586672783,
-0.019152740016579628,
-0.022749457508325577,
-0.005834369454532862,
-0.0025440100580453873,
-0.02638987824320793,
0.008014554157853127,
-0.008161218836903572,
0.009636091068387032,
0.022199328988790512,
-0.010698460973799229,
-0.006909572519361973,
-0.008898934349417686,
0.007145551033318043,
-0.016649451106786728,
-0.018886737525463104,
0.015094857662916183,
-0.004387340508401394,
0.001055864617228508,
-0.018679482862353325,
-0.00013882224448025227,
0.012440500780940056,
-0.015797261148691177,
-0.008135905489325523,
-0.040474310517311096,
0.00574950035661459,
0.038685835897922516,
-0.01237097755074501,
0.013716785237193108,
0.0002926529850810766,
0.008273445069789886,
0.02751263789832592,
0.013446329161524773,
-0.025213295593857765,
-0.0009742453694343567,
0.019614623859524727,
-0.001807978842407465,
0.020748654380440712,
-0.006648689974099398,
-0.02476523071527481,
0.010766561143100262,
0.008352932520210743,
-0.008178293704986572,
-0.011880948208272457,
0.0009845704771578312,
-0.03227023035287857,
0.004441144876182079,
0.022965680807828903,
0.013229618780314922,
0.009303158149123192,
0.005070004146546125,
-0.007271891459822655,
-0.009107103571295738,
0.010551944375038147,
0.022154398262500763,
-0.009177051484584808,
-0.017449628561735153,
-0.014018433168530464,
-0.0008977826219052076,
0.0016685414593666792,
-0.00950718205422163,
-0.0012566165532916784,
-0.002253057900816202,
-0.005149181466549635,
0.009577857330441475,
0.0149124376475811,
-0.022121436893939972,
-0.0069198524579405785,
-0.007364057470113039,
0.024383053183555603,
0.0073712910525500774,
0.01836226135492325,
-0.005528111942112446,
-0.01686379685997963,
0.016811413690447807,
-0.002901155734434724,
0.01094786450266838,
0.011265101842582226,
0.021245649084448814,
-0.0184515081346035,
0.03185177594423294,
0.006865628995001316,
0.015619343146681786,
0.006258890964090824,
-0.012596506625413895,
0.008332283236086369,
-0.014054198749363422,
-0.006261754781007767,
-0.024557743221521378,
0.017063692212104797,
0.0014281667536124587,
0.023686496540904045,
0.004061565734446049,
-0.005871759727597237,
-0.0009654946625232697,
-0.02490917034447193,
-0.011613447219133377,
0.03329043090343475,
0.00995531678199768,
0.002931578317657113,
0.01125408336520195,
-0.0010800217278301716,
0.07294932007789612,
-0.007249040529131889,
-0.0017930675530806184,
-0.00932516809552908,
0.016341419890522957,
0.0009748580632731318,
-0.028888514265418053,
-0.0007733539678156376,
-0.016304239630699158,
0.01668402925133705,
0.012502940371632576,
-0.011668079532682896,
-0.016253765672445297,
-0.02540808543562889,
-0.014588638208806515,
0.010426302440464497,
-0.007287540473043919,
-0.02728484570980072,
0.02585364133119583,
-0.0009008296765387058,
-0.014868954196572304,
-0.01691141165792942,
0.012337923049926758,
-0.05512167885899544,
-0.009362556971609592,
0.009893616661429405,
0.01538187637925148,
-0.00800413079559803,
-0.03233803063631058,
0.007931455038487911,
0.00031548901461064816,
0.015368827618658543,
-0.01003637257963419,
0.008900342509150505,
0.018855664879083633,
-0.007273513823747635,
0.019725698977708817,
-0.012484364211559296,
0.024416374042630196,
0.0032156705856323242,
0.014022939838469028,
-0.02124866284430027,
0.008772077038884163,
0.004705628380179405,
-0.006041913293302059,
-0.008024339564144611,
0.030312690883874893,
-0.005661931820213795,
-0.0009073112159967422,
-0.023928720504045486,
-0.005442695692181587,
-0.004992918111383915,
0.011563345789909363,
-0.0018268134444952011,
-0.011576248332858086,
-0.02152612991631031,
-0.02091875486075878,
-0.0034551972057670355,
-0.014957518316805363,
-0.01378323882818222,
0.0018292791210114956,
0.0035851430147886276,
-0.01656498573720455,
0.00422891927883029,
0.0126616470515728,
-0.002422444988042116,
0.0036747255362570286,
0.0058430638164281845,
-0.024493051692843437,
0.0021135900169610977,
-0.02516756020486355,
-0.02939806506037712,
-0.00757692102342844,
0.002813698025420308,
-0.020471643656492233,
-0.01254210527986288,
0.007638467475771904,
0.01763724721968174,
-0.016864150762557983,
-0.0014134389348328114,
-0.013861267827451229,
0.018587231636047363,
-0.005479215644299984,
-0.009113980457186699,
-0.007379467133432627,
0.01083652675151825,
-0.011643561534583569,
-0.07530869543552399,
-0.005730399861931801,
-0.01144361961632967,
-0.0032602939754724503,
-0.00777974259108305,
0.023393787443637848,
-0.021671444177627563,
0.003281611017882824,
-0.008745957165956497,
-0.001721775159239769,
-0.011618789285421371,
-0.014808133244514465,
0.004295432940125465,
0.01522939931601286,
0.010998345911502838,
0.00969300139695406,
0.005421961657702923,
-0.007003088481724262,
-0.015106075443327427,
0.014590964652597904,
-0.015071386471390724,
0.0044562313705682755,
-0.019921615719795227,
-0.004633817356079817,
-0.014910195022821426,
-0.08189067244529724,
0.0000363299623131752,
-0.014994917437434196,
-0.01927364617586136,
0.0036313263699412346,
-0.022199291735887527,
0.010417978279292583,
-0.01685112714767456,
-0.014803358353674412,
-0.01768536865711212,
0.0003533859271556139,
-0.004217653069645166,
0.008466843515634537,
-0.033621110022068024,
-0.026667935773730278,
-0.008276248350739479,
0.019546005874872208,
0.034523699432611465,
-0.0006477688439190388,
-0.0017989304615184665,
0.012697041034698486,
0.015738578513264656,
-0.006883941125124693,
0.012741629034280777,
-0.0022622288670390844,
-0.00683602737262845,
0.004323979374021292,
0.014798260293900967,
-0.020456012338399887,
-0.014982437714934349,
-0.01904478296637535,
-0.010889464989304543,
-0.018121346831321716,
-0.005402097944170237,
-0.015914516523480415,
-0.011607306078076363,
-0.02491185814142227,
0.003913411870598793,
-0.0069726016372442245,
-0.027889354154467583,
0.0006613887962885201,
-0.0030571133829653263,
-0.008380669169127941,
0.006127088330686092,
-0.009027646854519844,
0.01895880699157715,
0.006013250444084406,
-0.00251664686948061,
-0.003877639304846525,
-0.008474161848425865,
0.005550169385969639,
0.007305339444428682,
-0.013278430327773094,
-0.019360318779945374,
-0.007178405299782753,
0.015459856949746609,
-0.0049269432201981544,
0.002581366803497076,
0.012952884659171104,
0.00648973835632205,
-0.00005399552173912525,
0.02761269360780716,
0.016245512291789055,
0.07164299488067627,
-0.003237916389480233,
0.0008904633577913046,
-0.008364560082554817,
0.0019018212333321571,
0.008665842935442924,
0.025695037096738815,
-0.010532217100262642,
-0.013517100363969803,
-0.009871377609670162,
0.003954203799366951,
-0.0032122223637998104,
0.0034319148398935795,
0.01039230264723301,
0.00524538941681385,
-0.0024604378268122673,
-0.001190174836665392,
-0.008231999352574348,
-0.013985510915517807,
0.00442645326256752,
0.004785876255482435,
0.0008822446689009666,
-0.012699851766228676,
-0.013879537582397461,
0.0004002081695944071,
-0.010957877151668072,
-0.014530885964632034,
-0.01696636900305748,
-0.02226690575480461,
-0.025317586958408356,
0.012316280975937843,
-0.025966688990592957,
0.002759780501946807,
0.0072003924287855625,
-0.00798624474555254,
-0.0075850277207791805,
0.009408182464540005,
0.010606968775391579,
-0.007981953211128712,
-0.04216063395142555,
-0.004610290285199881,
-0.01915169693529606,
-0.011069661937654018,
0.019616374745965004,
0.025336921215057373,
0.006731881760060787,
-0.0101289302110672,
0.00145313935354352,
0.00970240868628025,
0.005153615027666092,
0.008625159040093422,
-0.004905163310468197,
-0.01237764023244381,
-0.023182030767202377,
0.01651918701827526,
0.034044623374938965,
-0.00867089256644249,
0.006672794930636883,
-0.014739153906702995,
0.0001381775364279747,
0.0028397529385983944,
-0.00604996457695961,
0.014242580160498619,
-0.02001243084669113,
0.031117316335439682,
0.01830179989337921,
0.0040737297385931015,
-0.01551106758415699,
0.005440117791295052,
0.01285089273005724,
0.016129298135638237,
-0.0128939775750041,
0.006451125256717205,
-0.011299360543489456,
0.02339044213294983,
0.01583746448159218,
0.015392158180475235,
-0.00939648412168026,
-0.0004922981606796384,
-0.004518992267549038,
0.001852276036515832,
0.001707191113382578,
0.025576122105121613,
0.01867535337805748,
0.006971357390284538,
-0.03477015346288681,
0.021476034075021744,
0.039373401552438736,
0.0037587329279631376,
0.0021858811378479004,
0.0035934275947511196,
0.0027866356540471315,
0.002824663184583187,
0.011356368660926819,
0.005810455419123173,
0.03420639783143997,
-0.007842017337679863,
0.0028543833177536726,
-0.01010175608098507,
0.007063285913318396,
0.002463578712195158,
0.0306443739682436,
0.0035371417179703712,
0.034459710121154785,
0.0201701857149601,
-0.017344696447253227,
-0.02430228516459465,
0.0014535924419760704,
0.02882777899503708,
0.02623128890991211,
-0.005007217638194561,
-0.01303642988204956,
0.0302366204559803,
-0.001270101871341467,
0.011898703873157501,
0.007878094911575317,
-0.004392207134515047,
0.01706991344690323,
0.00737522728741169,
-0.018848005682229996,
-0.010311895981431007,
-0.005878837779164314,
-0.013373911380767822,
0.0023644857574254274,
-0.0016962382942438126,
-0.017782963812351227,
-0.007027995306998491,
0.005899188108742237,
0.02415517345070839,
-0.007208120543509722,
0.014594640582799911,
0.03242942690849304,
-0.006231534294784069,
0.0018815213115885854,
-0.001490181777626276,
-0.006800528150051832,
-0.008249882608652115,
-0.0016053400468081236,
-0.012238402850925922,
0.016404572874307632,
0.0022317550610750914,
-0.013764575123786926,
-0.008271475322544575,
-0.013914118520915508,
0.008108070120215416,
0.0012464646715670824,
-0.026008285582065582,
-0.008666017092764378,
0.006184141151607037,
0.010392347350716591,
0.008173229172825813,
0.018947884440422058,
-0.00029873428866267204,
-0.010516192764043808,
0.019070740789175034,
0.024454232305288315,
0.0088931480422616,
0.011372641660273075,
-0.018761256709694862,
-0.03298294544219971,
-0.006217021960765123,
-0.015403274446725845,
-0.011569533497095108,
-0.0051288241520524025,
0.0026030857115983963,
0.02239636890590191,
-0.029062863439321518,
-0.004320039879530668,
0.004594271071255207,
-0.008519843220710754,
0.00032216269755735993,
-0.015407625585794449,
-0.017334528267383575,
-0.014777359552681446,
-0.02242889069020748,
0.005068967118859291,
-0.010049925185739994,
0.009078845381736755,
-0.0039642807096242905,
-0.0091036856174469,
0.003356931498274207,
-0.018948283046483994,
-0.011055374518036842,
-0.0024018283002078533,
0.007529260125011206,
0.01941475085914135,
-0.009176714345812798,
-0.0027577700093388557,
0.017956094816327095,
0.016932453960180283,
0.003808329813182354,
0.004798938520252705,
-0.005308233201503754,
0.012120362371206284,
-0.004716574680060148,
-0.0035453876480460167,
0.020362509414553642,
0.025251273065805435,
-0.0030604766216129065,
0.0027189492247998714,
0.0048205959610641,
-0.009763718582689762
] | [
0.12235984951257706,
-0.05797307938337326,
0.07343336194753647,
-0.11265365779399872,
-0.12179985642433167,
-0.16469237208366394,
-0.012865589000284672,
0.09701485186815262,
0.1704641878604889,
-0.02469887211918831,
-0.3140847682952881,
0.27875128388404846,
-0.46186530590057373,
0.15974393486976624,
0.1290503889322281,
0.7429463863372803,
0.3684120774269104,
0.9241167306900024,
-0.25933054089546204,
-0.6537046432495117,
-0.27866652607917786,
-0.0860825851559639,
0.6185981035232544,
-0.11204332858324051,
0.7263678908348083,
-0.16305924952030182,
-0.05684063583612442,
0.1724405139684677,
0.3233177959918976,
-0.16937516629695892,
0.3480561077594757,
0.8217666745185852,
0.15086856484413147,
-0.5245858430862427,
0.08544193208217621,
0.3132459223270416,
-0.5395222306251526,
-0.20503664016723633,
-0.5609506368637085,
-0.3993830382823944,
-0.6230672001838684,
-0.007855204865336418,
0.2404657006263733,
0.4592772126197815,
-0.26011693477630615,
0.19604802131652832,
-1.3501864671707153,
0.7403749227523804,
-0.35655102133750916,
0.3445722460746765,
0.1389811635017395,
0.023203715682029724,
0.07736214250326157,
-0.4589061737060547,
0.6244076490402222,
0.3032430112361908,
-1.1385090351104736,
0.022963406518101692,
0.25307759642601013,
-0.22066931426525116,
-0.030652500689029694,
0.14088022708892822,
-0.20151320099830627,
0.009327637031674385,
0.018005741760134697,
0.2735198438167572,
-0.19878454506397247,
-0.29889145493507385,
-0.7978284955024719,
-0.05227343738079071,
0.392642080783844,
-0.37729161977767944,
-0.5154808759689331,
0.34705066680908203,
-0.12105148285627365,
-0.4487616717815399,
-0.7308713793754578,
0.003971712198108435,
0.09920260310173035,
0.47490450739860535,
0.19076889753341675,
0.25915712118148804,
0.25345578789711,
0.05907478556036949,
0.2623956501483917,
-0.04559492692351341,
-0.18477632105350494,
1.0038111209869385,
-0.3740500807762146,
-0.13352571427822113,
0.025172462686896324,
0.22306624054908752,
0.6651439666748047,
0.30829426646232605,
0.03793269023299217,
0.0205807127058506,
0.22669175267219543,
-0.05746376886963844,
-0.45545509457588196,
-0.0768076702952385,
-0.5652527809143066,
0.4850108027458191,
-0.24015457928180695,
-0.4792996644973755,
-0.26859524846076965,
0.3951433598995209,
-0.363209068775177,
-0.25087037682533264,
-0.37345507740974426,
0.32376962900161743,
-0.7841911911964417,
0.14830994606018066,
-0.11671662330627441,
-0.2400837242603302,
-0.20589013397693634,
-0.4597197473049164,
0.28206300735473633,
0.33079367876052856,
-0.14972636103630066,
-0.20148998498916626,
0.08048628270626068,
0.9205966591835022,
-0.11688317358493805,
0.6263687014579773,
0.21472735702991486,
-0.2436855137348175,
0.2126573771238327,
-0.26566314697265625,
0.16479717195034027,
0.5829587578773499,
0.4813338816165924,
0.5472087264060974,
-0.17900040745735168,
-0.03077886439859867,
-0.27872028946876526,
0.10697583854198456,
0.05421885475516319,
0.16577908396720886,
0.7457172274589539,
0.010510523803532124,
-0.7305238246917725,
-0.3063678741455078,
-0.3519861698150635,
0.02364981546998024,
-0.2644023001194,
-0.39509135484695435,
-0.191839799284935,
0.39653024077415466,
0.26498621702194214,
-0.30160143971443176,
0.34695735573768616,
-0.3183775246143341,
-0.9423204660415649,
-0.16933871805667877,
0.06823061406612396,
0.2500372529029846,
0.1563948094844818,
-0.4247612953186035,
-0.02654779516160488,
0.02471265196800232,
0.10765130072832108,
-0.005883220583200455,
0.24383433163166046,
-0.4273693561553955,
0.7454829216003418,
-0.03644830361008644,
-0.4184027910232544,
0.22778454422950745,
0.023941459134221077,
0.13093161582946777,
-0.6857016086578369,
-0.20756779611110687,
0.3800766170024872,
-0.5725604295730591,
0.26035985350608826,
-0.3329646587371826,
0.20906369388103485,
-0.0033260430209338665,
0.264130562543869,
0.0556640662252903,
-0.6454015970230103,
0.3107030987739563,
-0.12298435717821121,
-0.38042306900024414,
0.21315230429172516,
0.31505346298217773,
0.7598183751106262,
-0.32072246074676514,
0.3316761553287506,
0.20967429876327515,
-0.4387785494327545,
-0.6457842588424683,
0.49810969829559326,
-0.2921771705150604,
0.7411898374557495,
-0.3233073651790619,
-0.07956931740045547,
0.31857573986053467,
0.0931517630815506,
-0.22887705266475677,
-0.15444178879261017,
0.14638282358646393,
0.8648817539215088,
-0.6051781177520752,
-1.0580731630325317,
0.15413983166217804,
0.15367485582828522,
-0.4505734443664551,
0.1777484118938446,
0.5316178202629089,
0.665074348449707,
-0.27164962887763977,
0.1438150256872177,
-0.40239962935447693,
0.3421999514102936,
-0.5383939743041992,
0.014312725514173508,
0.13892386853694916,
-0.011855103075504303,
0.09385336190462112,
0.28881341218948364,
-0.1788543164730072,
0.333824098110199,
0.7317126989364624,
-0.18698424100875854,
0.701508641242981,
0.19827035069465637,
0.26707127690315247,
0.4293311834335327,
0.1922367364168167,
0.18610718846321106,
-0.31853917241096497,
-0.12818342447280884,
-0.16833218932151794,
-0.08676777780056,
-0.17858275771141052,
-0.1663510650396347,
0.04140620306134224,
0.23691660165786743,
-0.3975828289985657,
0.19781158864498138,
0.1496208757162094,
-0.7088962197303772,
-0.2667928636074066,
0.16750888526439667,
-0.4174347221851349,
-0.38275229930877686,
0.23483823239803314,
-0.6549356579780579,
0.08782842010259628,
0.14217647910118103,
0.31539490818977356,
0.20836606621742249,
-0.1869039535522461,
-0.1351008415222168,
0.054599568247795105,
-0.051149651408195496,
0.018536940217018127,
0.041838809847831726,
-0.22967039048671722,
-0.5386989712715149,
0.3705010712146759,
0.09982983767986298,
0.1678248792886734,
0.5204414129257202,
-0.3371097445487976,
-0.7535962462425232,
-0.37511563301086426,
1.1732038259506226,
-0.11464395374059677,
1.1778690814971924,
-0.19885200262069702,
-0.8164246678352356,
-0.32770347595214844,
-0.5546867251396179,
-0.2668289840221405,
0.34671127796173096,
0.3234463930130005,
-0.3754256069660187,
-0.5117262005805969,
-0.25059518218040466,
0.3937849700450897,
0.6910775303840637,
0.06311138719320297,
-0.40877604484558105,
0.13692893087863922,
-0.21241338551044464,
-0.7336089015007019,
-0.28492242097854614,
-0.681452214717865,
-0.12796589732170105,
0.2088160216808319,
-0.4349048137664795,
0.07186024636030197,
0.4017353057861328,
-0.3913467824459076,
0.15172773599624634,
0.8615458011627197,
0.5308512449264526,
-0.4864790439605713,
-0.10945242643356323,
0.3554966151714325,
-0.30148109793663025,
-0.12129274010658264,
0.17051509022712708,
0.035137806087732315,
0.09349749237298965,
0.1229202076792717,
-5.868948936462402,
0.2770002484321594,
-0.4481584131717682,
0.15368150174617767,
0.41394808888435364,
-0.292625367641449,
0.6237037777900696,
-0.46420738101005554,
0.007727217394858599,
0.07391190528869629,
0.15311235189437866,
0.14269864559173584,
0.267757773399353,
-0.35745489597320557,
-0.2745165526866913,
-0.21388427913188934,
-0.5063683390617371,
-0.42462536692619324,
0.6840287446975708,
0.17832893133163452,
0.26319098472595215,
-0.09734852612018585,
0.055569838732481,
0.9644214510917664,
-0.052696093916893005,
-0.04530821368098259,
-0.19635529816150665,
0.43233975768089294,
-0.4176763892173767,
-0.6574805974960327,
-0.018633490428328514,
-0.296999454498291,
0.21912841498851776,
-0.15967334806919098,
0.26817232370376587,
-0.3719920516014099,
-0.015678081661462784,
-0.2663814127445221,
-0.19154450297355652,
-0.22867301106452942,
0.02940630167722702,
0.047913797199726105,
0.12450813502073288,
-0.44803062081336975,
0.5951780080795288,
-0.1883549690246582,
0.0756179615855217,
-0.2847125232219696,
-0.10783356428146362,
1.033311367034912,
0.26041141152381897,
0.16546307504177094,
-0.30604273080825806,
0.42476168274879456,
0.2976323962211609,
0.10331032425165176,
-0.0036119516007602215,
0.0016216083895415068,
0.32267019152641296,
0.2917150855064392,
0.08738187700510025,
0.2682362198829651,
0.1096324771642685,
-0.18676148355007172,
0.22718720138072968,
0.2254095822572708,
-0.2721196711063385,
-0.22999554872512817,
0.2223028689622879,
-0.4648812711238861,
-0.15027111768722534,
0.2094762772321701,
0.2213146686553955,
-0.7835214138031006,
0.18367142975330353,
-0.2467651069164276,
-0.034026507288217545,
0.19690190255641937,
0.1360168308019638,
0.5799928903579712,
-0.4665107727050781,
-0.28030115365982056,
-0.014674804173409939,
-0.13430294394493103,
-0.1716235727071762,
-0.413376122713089,
-0.26856622099876404,
0.14323483407497406,
0.04180828109383583,
0.40335044264793396,
0.2756641209125519,
-0.8029984831809998,
0.19100403785705566,
0.35030561685562134,
0.006021372973918915,
0.20482385158538818,
0.24737095832824707,
0.8263155817985535,
0.6633098721504211,
0.36840829253196716,
0.5367245674133301,
-0.2208181768655777,
-0.2574647068977356,
-0.5495830178260803,
0.2504594326019287,
-0.23153313994407654,
-0.08357033133506775,
-0.14771094918251038,
0.9889948964118958,
-0.9601628184318542,
0.5357911586761475,
0.24921198189258575,
-0.5740842223167419,
-0.11603324115276337,
0.9805538058280945,
-0.3693171441555023,
0.07971759885549545,
0.0485287606716156,
0.5624450445175171,
-0.44520583748817444,
0.17015038430690765,
0.2497205287218094,
-0.5411162376403809,
0.41160285472869873,
0.26096588373184204,
-0.17831841111183167,
0.2502579391002655,
0.7079706192016602,
-0.4548782706260681,
0.30822309851646423,
0.03128860145807266,
0.19943279027938843,
0.023886673152446747,
-0.4256667196750641,
0.1840842217206955,
-0.11583219468593597,
-0.4628780484199524,
0.5885976552963257,
0.12994438409805298,
-0.1030692383646965,
-0.027433687821030617,
-0.41728171706199646,
-0.14723651111125946,
-0.12360087782144547,
0.6307927370071411,
0.21616347134113312,
-0.1094730868935585,
-0.10154226422309875,
-0.2515977621078491,
-0.2689867615699768,
0.2552000880241394,
0.5826529264450073,
0.30931761860847473,
0.2250949889421463,
-0.01684139296412468,
0.02223198115825653,
0.49584200978279114,
0.43718260526657104,
-0.07719766348600388,
-0.857633113861084,
0.5371099710464478,
0.02939312718808651,
-1.0151879787445068,
0.012768679298460484,
-0.014348209835588932,
-0.5468990802764893,
0.18318773806095123,
-0.5635427236557007,
-0.0527196042239666,
0.14327797293663025,
-0.2994757294654846,
-0.2457946389913559,
0.1113574206829071,
0.14142708480358124,
-0.07964930683374405,
-0.056644462049007416,
-0.4568547010421753,
-0.25841033458709717,
-0.2692885994911194,
-0.038439128547906876,
0.21292337775230408,
-0.47154828906059265,
-0.21839109063148499,
0.19026468694210052,
0.18218320608139038,
-0.00795393344014883,
-0.42189857363700867,
-0.22736142575740814,
-0.07157964259386063,
-0.1278553009033203,
0.032757509499788284,
0.04876456782221794,
-0.38754162192344666,
-0.11288506537675858,
0.2366066873073578,
0.3335302770137787,
0.05491826683282852,
-0.023020919412374496,
0.1498735398054123,
-0.5322567224502563,
0.19328023493289948,
0.23395876586437225,
0.1967255175113678,
-0.04617055132985115,
0.1287185102701187,
-0.15788306295871735,
0.11770107597112656,
0.5947161316871643,
-0.48236677050590515,
-0.03846500441431999,
0.05744364112615585,
-0.796485424041748,
0.3626081347465515,
0.300493448972702,
-0.24533383548259735,
0.2977786362171173,
0.11520064622163773,
-0.17678621411323547,
-0.2919549345970154,
-0.26685279607772827,
0.3933645486831665,
-0.4834330081939697,
0.24901874363422394,
0.09303021430969238,
-0.8531750440597534,
0.22978496551513672,
0.4023049771785736,
-0.7813521027565002,
0.6950129270553589,
0.1049758568406105,
-0.03647790104150772,
0.4366558790206909,
0.17471370100975037,
0.7502073049545288,
0.02804979681968689,
0.006208834238350391,
-0.5019977688789368,
0.10826670378446579,
-0.6482001543045044,
0.16110661625862122,
-0.0904180258512497,
0.36659568548202515,
-0.3649061918258667,
0.20536857843399048,
0.1156795471906662,
0.882804274559021,
0.010533946566283703,
-0.21264296770095825,
-0.21557316184043884,
-0.09589957445859909,
0.6361219882965088,
-0.17133298516273499,
0.34860479831695557,
-0.05876093730330467,
0.6362380981445312,
-0.6039435267448425,
0.3386734426021576,
-0.41654688119888306,
-0.5917089581489563,
0.3721187114715576,
-0.3165442943572998,
0.3347899913787842,
-0.12200038135051727,
1.129467487335205,
0.5014187097549438,
-0.10807634145021439,
-0.11902961134910583,
-0.6096045970916748,
0.34233540296554565,
-0.2597142159938812,
-0.15090669691562653,
-0.06370878964662552,
0.6493251323699951,
0.632166862487793,
-0.021848104894161224,
0.3927389085292816,
-0.20999592542648315,
-1.00774347782135,
-0.16526053845882416,
0.10041923820972443,
-0.564454972743988,
-0.5029428005218506,
0.18032808601856232,
-0.5582186579704285,
0.14985232055187225,
-0.5731527209281921,
-0.07387328147888184,
-0.4593510031700134,
-0.31227096915245056,
0.025980139151215553,
0.08339133113622665,
0.2993427813053131,
-0.4842000901699066,
-0.40837758779525757,
-0.19705842435359955,
-0.1983575075864792,
-0.0880521908402443,
-0.004136469680815935,
0.45343101024627686,
-0.24886392056941986,
-0.5751737952232361,
0.37093448638916016,
0.6140248775482178,
-0.06064579263329506,
-0.13041536509990692,
0.441083163022995,
0.07059342414140701,
-0.09253077954053879,
-0.3324223458766937,
-0.24963919818401337,
0.17493900656700134,
0.0341169647872448,
0.11494063585996628,
0.15189753472805023,
-0.36546576023101807,
0.4200969636440277,
0.25089406967163086,
-0.03600430488586426,
0.19293171167373657,
0.5036006569862366,
0.4329899549484253,
0.5325626730918884,
0.20961369574069977,
0.21734654903411865,
-0.28120318055152893,
0.04354342073202133,
0.09750901162624359,
0.1146748960018158,
0.05699525028467178,
0.6631721258163452,
0.3038081228733063,
0.6270284652709961,
-0.1729070395231247,
0.9832932353019714,
0.23151348531246185,
-0.41828250885009766,
-0.29448965191841125,
-0.5258886814117432,
-0.10821458697319031,
0.08644665032625198,
1.0314363241195679,
-0.2574774920940399,
-0.0011722225463017821,
0.027397211641073227,
0.17593877017498016,
0.3574911952018738,
0.10383216291666031,
-0.3325156271457672,
-0.33125433325767517,
0.5594374537467957,
-0.04872389882802963,
-0.015943190082907677,
-0.3174198865890503,
-0.3642273247241974,
-0.6413219571113586,
0.692985475063324,
0.3481104373931885,
-0.09843506664037704,
-0.9190212488174438,
0.058747097849845886,
-0.7401593923568726,
0.3461933732032776,
0.2693771421909332,
0.5471816062927246,
-0.19198395311832428,
0.1542084515094757,
-0.042312100529670715,
-0.46156182885169983,
0.07293982803821564,
0.08009569346904755,
-0.11342372000217438,
-0.4326394498348236,
-0.6639692187309265,
0.11178530752658844,
0.5120314955711365,
0.3277118504047394,
0.13631005585193634,
0.05100717023015022,
-0.05012454837560654,
0.3831881284713745,
-0.8002098798751831,
-0.015237070620059967,
-0.4230138957500458,
-0.5704088807106018,
-0.4882694482803345,
0.08148118853569031,
-0.4770221710205078,
-0.2689239978790283,
-0.5026723742485046,
0.1101183369755745,
-0.018440334126353264,
-0.20131376385688782,
0.7091896533966064,
-0.010297534987330437,
0.3748674690723419,
-0.15678241848945618,
0.19386176764965057,
-0.12155918031930923,
-0.022438660264015198,
0.24848976731300354,
0.1856623888015747,
0.5254963636398315,
0.02735443226993084,
0.05701137334108353,
-0.6552377939224243,
0.4256187677383423,
-0.4797128438949585,
-0.2672644555568695,
-0.3834066689014435,
-0.14047609269618988,
0.6832276582717896,
0.6856961846351624,
-0.16269904375076294,
0.16277208924293518,
0.2920375466346741,
0.05278833210468292,
0.3537343740463257,
-0.6079973578453064,
-0.10736432671546936,
-0.3697381019592285,
-0.18154439330101013,
-0.13513804972171783,
0.09254363179206848,
-0.23903422057628632,
-0.07172857969999313,
0.4509223997592926,
0.222062349319458,
0.7824140191078186,
-0.6332913041114807,
0.4185391366481781,
-0.18221226334571838,
0.3157365918159485,
-0.902341902256012,
0.099214106798172,
-0.5112672448158264,
0.2897219955921173,
0.15690307319164276,
0.2094155251979828,
-0.352109432220459,
-0.07339484989643097,
-0.15612949430942535,
-0.10440894216299057,
0.04056701809167862,
-0.6335275769233704,
-0.14881625771522522,
-0.12753576040267944,
0.0914822369813919,
-0.8346084952354431,
-0.5981469750404358,
0.3630535900592804,
0.12870261073112488,
-0.5106850862503052,
-0.07235604524612427,
0.6978424787521362,
0.21094265580177307,
-0.032022714614868164,
0.2526434659957886,
-0.27177760004997253,
0.05340351164340973,
-0.15877437591552734
] |
DNA recognition by TAL effectors is mediated by tandem repeats, each 33 to 35 residues in length, that specify nucleotides via unique repeat-variable diresidues (RVDs). The crystal structure of PthXo1 bound to its DNA target was determined by high-throughput computational structure prediction and validated by heavy-atom derivatization. Each repeat forms a left-handed, two-helix bundle that presents an RVD-containing loop to the DNA. The repeats self-associate to form a right-handed superhelix wrapped around the DNA major groove. The first RVD residue forms a stabilizing contact with the protein backbone, while the second makes a base-specific contact to the DNA sense strand. Two degenerate amino-terminal repeats also interact with the DNA. Containing several RVDs and noncanonical associations, the structure illustrates the basis of TAL effector-DNA recognition. | [
-0.00013525644317269325,
0.011311359703540802,
-0.019596032798290253,
0.010493366047739983,
-0.0052566127851605415,
-0.009235831908881664,
0.009170552715659142,
0.022296197712421417,
-0.007754659280180931,
-0.012132823467254639,
-0.009265769273042679,
0.002933718729764223,
-0.01676367223262787,
0.012043420225381851,
-0.00793930608779192,
0.016130264848470688,
-0.00883532129228115,
-0.009840698912739754,
0.012924782000482082,
0.005462490953505039,
0.004784490913152695,
0.020895052701234818,
0.009886928834021091,
0.0030591986142098904,
-0.003082951530814171,
-0.0045319730415940285,
0.009805167093873024,
0.006276689004153013,
0.01419941708445549,
0.013825440779328346,
-0.001592176966369152,
0.0033849957399070263,
0.003832824993878603,
0.0232667438685894,
-0.006248789373785257,
-0.01059343945235014,
-0.008970106020569801,
0.020001757889986038,
0.04200978949666023,
-0.005363065749406815,
-0.002792889717966318,
-0.014039774425327778,
0.004007790237665176,
-0.009184313006699085,
-0.009797342121601105,
0.0038955463096499443,
-0.0009621421922929585,
-0.005186581984162331,
-0.0076366933062672615,
0.006530340760946274,
-0.01499675028026104,
0.026195552200078964,
-0.010163099505007267,
0.0386003702878952,
-0.005457224324345589,
-0.02095242775976658,
0.01865454390645027,
-0.003168816212564707,
-0.002720704535022378,
0.024255111813545227,
0.01638437621295452,
0.005418300628662109,
-0.01683741994202137,
-0.027334483340382576,
-0.02473071590065956,
-0.06735767424106598,
0.008360031060874462,
0.03641696274280548,
-0.009413057938218117,
0.025885267183184624,
-0.0054892608895897865,
0.009433288127183914,
-0.01421914342790842,
0.026962099596858025,
-0.003032844513654709,
0.010452027432620525,
-0.0014768338296562433,
-0.0011381180956959724,
0.010445544496178627,
0.023635270074009895,
-0.034453924745321274,
-0.010778680443763733,
0.01783991977572441,
0.003159974468871951,
-0.00028817111160606146,
0.02099752053618431,
0.0035627090837806463,
-0.0008162232115864754,
0.011377409100532532,
0.0028305724263191223,
-0.009515850804746151,
-0.027190985158085823,
-0.007566412910819054,
-0.003969031386077404,
-0.044245585799217224,
-0.002670097630470991,
-0.006212493404746056,
0.0148039311170578,
0.0035666795447468758,
0.013538302853703499,
-0.02034607157111168,
-0.005997501779347658,
0.022861819714307785,
-0.017678774893283844,
-0.0025518389884382486,
0.005465524736791849,
-0.00862470455467701,
0.00900581106543541,
0.008471393957734108,
0.004100143909454346,
0.013581064529716969,
-0.01388034038245678,
-0.012611807323992252,
0.00937495008111,
-0.003244282677769661,
-0.003609794657677412,
0.005795988254249096,
0.019831618294119835,
0.007801871746778488,
0.014978036284446716,
-0.022610820829868317,
-0.01136953104287386,
-0.010434156283736229,
-0.0040311310440301895,
0.007661482784897089,
-0.01334192231297493,
0.009448385797441006,
0.008346391841769218,
0.008841147646307945,
0.014716741628944874,
-0.011165520176291466,
0.0016627993900328875,
0.0020517325028777122,
-0.018092041835188866,
-0.002367889741435647,
0.0018829188775271177,
-0.009885980747640133,
-0.026858903467655182,
0.002151886932551861,
-0.006285734474658966,
0.012676412239670753,
0.005049743689596653,
0.0014355587773025036,
0.01667078770697117,
0.0036251514684408903,
0.009572699666023254,
0.006080309394747019,
-0.0020458484068512917,
0.013133026659488678,
-0.0366484671831131,
0.0009211946744471788,
-0.008167030289769173,
-0.01640252396464348,
-0.009879577904939651,
0.0021150773391127586,
-0.0006940639577805996,
-0.016343720257282257,
-0.015339342877268791,
-0.007540576625615358,
0.025543859228491783,
0.0038552042096853256,
-0.009287599474191666,
-0.006899791769683361,
0.009088277816772461,
0.01193792000412941,
0.007415509782731533,
0.0012072846293449402,
-0.0006150606204755604,
0.000180091243237257,
0.00563314463943243,
0.0023818458430469036,
0.019343296065926552,
-0.0012937108986079693,
0.007644050754606724,
-0.02210516855120659,
-0.0005200575105845928,
-0.013371876440942287,
0.00539583433419466,
-0.024182328954339027,
0.06684327125549316,
0.013208149001002312,
-0.02047639712691307,
-0.010018986649811268,
0.005278843455016613,
0.03986179828643799,
-0.015876615419983864,
0.010735218413174152,
-0.008939280174672604,
-0.0030148292426019907,
-0.02212313562631607,
0.009217808023095131,
0.018706226721405983,
0.011603503488004208,
-0.0026475368067622185,
-0.008550954051315784,
0.0012150637339800596,
-0.004552504979074001,
0.0013884303625673056,
0.010934150777757168,
0.004703762475401163,
0.007510432042181492,
-0.005866545252501965,
-0.0034033863339573145,
-0.01914258860051632,
-0.005185190588235855,
0.0037904379423707724,
0.002921053674072027,
-0.01503404788672924,
0.0028378935530781746,
0.028441213071346283,
0.023393336683511734,
-0.006330553442239761,
-0.007940307259559631,
-0.0026066158898174763,
0.007119436748325825,
0.009378915652632713,
0.008865924552083015,
0.0038626035675406456,
0.005389240104705095,
-0.011461690999567509,
-0.0019315250683575869,
0.009356679394841194,
0.016376547515392303,
-0.0070494068786501884,
0.031100163236260414,
0.01085252221673727,
-0.006085271947085857,
0.012111194431781769,
-0.0034869324881583452,
-0.0033633147832006216,
0.008820051327347755,
-0.023745112121105194,
-0.013260051608085632,
0.00361854350194335,
0.0017367475666105747,
-0.0015903820749372244,
0.011762609705328941,
-0.015962976962327957,
0.015061631798744202,
-0.00538061885163188,
-0.02475329115986824,
-0.025960564613342285,
0.01665792241692543,
-0.00953763909637928,
-0.014055849984288216,
0.0015952030662447214,
-0.015928704291582108,
-0.0025215735659003258,
0.003489261493086815,
-0.014730215072631836,
0.007429201155900955,
-0.0030023399740457535,
0.023413321003317833,
-0.034255754202604294,
0.015694884583353996,
-0.005103467497974634,
0.03539571911096573,
-0.008128258399665356,
0.02356024459004402,
-0.022174419835209846,
0.00561697781085968,
0.0076977889984846115,
-0.015839457511901855,
-0.03005816787481308,
-0.03684517741203308,
0.0062238737009465694,
0.004981504287570715,
-0.0015471852384507656,
-0.0026224274188280106,
-0.009721081703901291,
0.012737683020532131,
-0.012120790779590607,
-0.0012801706325262785,
-0.0814337283372879,
-0.006048852577805519,
0.005582308396697044,
-0.0031114055309444666,
0.007995867170393467,
-0.0068898070603609085,
-0.0062444475479424,
0.014287177473306656,
-0.010249386541545391,
0.005021328572183847,
0.02283022180199623,
0.004972085822373629,
-0.016819920390844345,
0.003261356148868799,
0.0023620277643203735,
-0.007155156694352627,
0.015526920557022095,
-0.012140125967562199,
0.005678026005625725,
-0.009203722700476646,
0.019550595432519913,
0.02523801475763321,
-0.016964789479970932,
-0.0020885877311229706,
-0.03146811202168465,
0.014892995357513428,
0.010867464356124401,
0.011245641857385635,
-0.04213513433933258,
0.0014947183663025498,
-0.009157928638160229,
-0.036627963185310364,
0.0017451327294111252,
-0.0032377629540860653,
0.0043981075286865234,
-0.0117832375690341,
-0.005678705871105194,
-0.02986665442585945,
-0.010081754066050053,
0.021530987694859505,
0.005133712198585272,
0.012485334649682045,
-0.009657811373472214,
0.010338987223803997,
-0.004253938794136047,
0.019661875441670418,
-0.009087126702070236,
0.008053293451666832,
0.021741772070527077,
0.0011129346676170826,
-0.011193836107850075,
0.007524830289185047,
0.016458094120025635,
0.01343678217381239,
0.00007965436088852584,
-0.020316706970334053,
-0.01707066223025322,
-0.0033329729922115803,
-0.009729892015457153,
-0.012415762059390545,
-0.012668929994106293,
-0.028081603348255157,
0.013111123815178871,
-0.011552447453141212,
0.02258363738656044,
-0.02028847299516201,
0.01580117829144001,
-0.007098594680428505,
-0.013482732698321342,
-0.002818928100168705,
0.01741241291165352,
-0.0026838553603738546,
-0.02608931064605713,
-0.0012824572622776031,
-0.007172760087996721,
-0.020232336595654488,
-0.01360931247472763,
0.0015716712223365903,
0.023585811257362366,
-0.01066394243389368,
-0.022104116156697273,
0.008463697507977486,
-0.008848598226904869,
-0.0071960994973778725,
-0.02129632979631424,
-0.019183702766895294,
0.01002440880984068,
0.03340567648410797,
0.013453079387545586,
-0.005954280495643616,
0.013965671882033348,
0.014828546904027462,
-0.006913433782756329,
0.010078152641654015,
-0.011608246713876724,
0.003467992413789034,
-0.012149198912084103,
0.007760064210742712,
-0.00039137457497417927,
0.009188327938318253,
-0.0032408395782113075,
-0.002950971480458975,
0.0016663058195263147,
-0.010014418512582779,
-0.039494432508945465,
0.011109109967947006,
-0.004547355230897665,
-0.013492530211806297,
0.0029852071311324835,
-0.00456616235896945,
0.0002748358529061079,
-0.011399222537875175,
-0.00734330341219902,
0.007777840364724398,
0.00636350829154253,
-0.00837717205286026,
-0.011061681434512138,
0.015841903164982796,
0.07301519811153412,
0.005789126269519329,
0.010190345346927643,
-0.013817884027957916,
-0.010270186699926853,
-0.032516270875930786,
-0.021269574761390686,
0.018876299262046814,
0.020127294585108757,
0.001216656994074583,
0.010756065137684345,
0.005249583162367344,
0.0030082520097494125,
-0.016394760459661484,
-0.017580004408955574,
-0.016850177198648453,
0.003525051288306713,
0.026054978370666504,
-0.010640188120305538,
-0.0047945668920874596,
0.01610642671585083,
-0.031651757657527924,
-0.015791667625308037,
0.00763089582324028,
-0.00003648828715085983,
-0.010585159063339233,
0.010603443719446659,
-0.017241256311535835,
0.002720612334087491,
0.014122026972472668,
0.035580530762672424,
-0.0012721437960863113,
-0.0072885537520051,
0.0009930082596838474,
0.006526567041873932,
-0.011256259866058826,
0.01154262013733387,
0.02047770842909813,
0.004095373209565878,
0.003971113357692957,
-0.026398003101348877,
-0.013974511995911598,
0.01939011737704277,
0.009598225355148315,
-0.006220761686563492,
0.013827691785991192,
0.020246848464012146,
-0.007226467598229647,
-0.006641520652920008,
0.0001425938680768013,
-0.013033820316195488,
-0.007096757646650076,
0.014940491877496243,
0.00485121738165617,
0.01635850965976715,
-0.02551010623574257,
0.008893100544810295,
-0.014294784516096115,
0.004717846401035786,
-0.023448720574378967,
0.0007035238668322563,
-0.027875356376171112,
0.0032812077552080154,
-0.018648525699973106,
0.0076235318556427956,
-0.036419980227947235,
0.01695936545729637,
-0.00749548664316535,
-0.013150705024600029,
-0.027367975562810898,
0.02303987368941307,
-0.025890931487083435,
-0.033222049474716187,
-0.004107378423213959,
-0.009114570915699005,
0.0042179725132882595,
0.017912667244672775,
-0.014167256653308868,
0.0010393690317869186,
-0.01760067790746689,
-0.024556733667850494,
0.01472147461026907,
-0.00894403550773859,
0.006679100915789604,
-0.0069634392857551575,
0.007825106382369995,
-0.018474845215678215,
-0.07526970654726028,
-0.008251531980931759,
0.01595851220190525,
-0.005379419308155775,
-0.020703788846731186,
0.021823972463607788,
0.004546932876110077,
-0.011886958964169025,
0.024598881602287292,
-0.009823654778301716,
0.012820336036384106,
0.0022934903390705585,
0.007292895577847958,
-0.026370428502559662,
0.009494151920080185,
0.01255391351878643,
-0.02137800119817257,
0.012162849307060242,
-0.016208646818995476,
0.01007135957479477,
0.0024594771675765514,
0.006039985455572605,
-0.033701226115226746,
-0.012962181121110916,
-0.00012015504762530327,
-0.08185049891471863,
-0.00677645206451416,
0.010758618824183941,
-0.014985773712396622,
-0.022205941379070282,
-0.004686114378273487,
0.015048795379698277,
0.005320417694747448,
0.01900520548224449,
-0.010934634134173393,
0.020202267915010452,
0.0048964056186378,
0.012152839452028275,
0.002414724789559841,
0.000870885793119669,
-0.011446593329310417,
0.00559978885576129,
0.004385797772556543,
-0.00041390443220734596,
-0.011926358565688133,
-0.012155427597463131,
-0.001691792393103242,
-0.009887101128697395,
0.004967380315065384,
-0.010390333831310272,
-0.014450686983764172,
-0.029352804645895958,
0.014699994586408138,
-0.0035705403424799442,
-0.021776068955659866,
0.011743690818548203,
0.0008596135303378105,
-0.012348048388957977,
-0.02111562341451645,
0.0034167293924838305,
-0.022022774443030357,
0.009371872060000896,
0.0034222789108753204,
0.005962722934782505,
-0.01991203799843788,
-0.004611680284142494,
0.00451113935559988,
-0.006054387893527746,
0.0002810796722769737,
-0.009301786310970783,
-0.04075747728347778,
0.005313180387020111,
-0.010195093229413033,
0.002753573004156351,
-0.015961455181241035,
0.004678737372159958,
-0.03284067660570145,
-0.003120782319456339,
0.01228129118680954,
0.018928833305835724,
0.02030172571539879,
0.0013570616720244288,
0.008504177443683147,
-0.0038879509083926678,
-0.0034458180889487267,
-0.00799531489610672,
0.009509370662271976,
-0.013114435598254204,
0.07214599847793579,
-0.018055137246847153,
0.011284906417131424,
-0.024727918207645416,
-0.00935707613825798,
0.0058077555149793625,
-0.0049922168254852295,
-0.013034815900027752,
0.010700106620788574,
-0.029836978763341904,
0.014890912920236588,
-0.013786683790385723,
0.01025339774787426,
0.005926874931901693,
0.027646346017718315,
0.02003544196486473,
0.0081821009516716,
-0.008869411423802376,
-0.0033246641978621483,
-0.00019298167899250984,
-0.018888479098677635,
0.020778249949216843,
-0.033145975321531296,
-0.0012788036838173866,
0.008533900603652,
0.0076460884883999825,
-0.012727380730211735,
-0.029159393161535263,
0.001520628109574318,
0.015752945095300674,
0.016150405630469322,
0.0012248321436345577,
0.003286105813458562,
-0.005167410708963871,
0.012248623184859753,
-0.012979278340935707,
0.008957549929618835,
0.014423917979001999,
-0.025970717892050743,
0.006906003225594759,
-0.015766886994242668,
-0.001045534387230873,
-0.002935773925855756,
-0.006045118439942598,
0.016632672399282455,
0.006273022387176752,
0.028121916577219963,
-0.015299826860427856,
0.022266142070293427,
-0.004465044010430574,
0.028279663994908333,
-0.004036891274154186,
0.037001632153987885,
-0.011996590532362461,
0.011173853650689125,
-0.010835043154656887,
-0.007013276219367981,
0.0157953891903162,
-0.021186023950576782,
-0.0037621241062879562,
0.003939663525670767,
-0.012349387630820274,
-0.004781190771609545,
-0.012547140941023827,
0.005494657903909683,
-0.031831830739974976,
-0.005573439411818981,
-0.02281564101576805,
0.008716561831533909,
0.01117461733520031,
0.017791805788874626,
0.010006713680922985,
0.008180001750588417,
0.039630189538002014,
0.022419899702072144,
-0.008464895188808441,
-0.00915391743183136,
-0.007490813732147217,
0.023746432736516,
-0.0029688766226172447,
-0.008180422708392143,
0.0009169420227408409,
-0.003251604037359357,
0.0036625107750296593,
-0.005571911111474037,
0.004890581592917442,
-0.00154934823513031,
-0.01962117850780487,
0.0019787978380918503,
0.009956480003893375,
0.0264749713242054,
0.0024773147888481617,
0.006813498213887215,
-0.002018466591835022,
0.0034325667656958103,
0.033048488199710846,
0.022212687879800797,
0.004286934621632099,
0.02392505295574665,
-0.005708801094442606,
0.03990247845649719,
-0.006120303645730019,
-0.02020539715886116,
0.00535404309630394,
0.012774359434843063,
0.008338474668562412,
-0.0022056428715586662,
-0.014705872163176537,
-0.011781703680753708,
-0.003921616822481155,
0.020429950207471848,
0.013781432993710041,
-0.005078606307506561,
0.015216815285384655,
0.005011091940104961,
0.0269936416298151,
-0.011459164321422577,
-0.00842086598277092,
0.014885785058140755,
-0.011952782981097698,
-0.0037147647235542536,
0.008961090818047523,
-0.008749786764383316,
0.04309949651360512,
-0.011428384110331535,
0.006056731566786766,
-0.004838969092816114,
-0.013990341685712337,
0.004253122489899397,
-0.007417215034365654,
0.021998578682541847,
0.005429551936686039,
-0.007267890963703394,
0.0000611280556768179,
0.015588668175041676,
-0.006949967704713345,
0.0017099790275096893,
-0.024522610008716583,
0.009151868522167206,
-0.0007839368190616369,
0.002749077510088682,
-0.015784792602062225,
0.002632543444633484,
-0.004611385054886341,
0.006966422777622938,
-0.033887870609760284,
0.01779002696275711,
-0.0012618268374353647,
0.007818317040801048,
-0.0014744605869054794,
0.01349647156894207,
-0.0021940069273114204,
-0.003843179438263178,
-0.004731163382530212,
0.03685149550437927,
0.006957517005503178,
0.015364441089332104,
0.012728367000818253,
-0.00694645568728447,
0.004616802092641592,
0.00665703509002924,
0.02036415785551071,
0.013885711319744587,
0.009133673273026943,
0.007557961158454418,
-0.0007030689157545567,
0.009592816233634949,
0.03471037745475769,
-0.008380348794162273,
-0.04904870688915253,
0.028558654710650444,
0.011737531051039696,
-0.016397353261709213,
0.012416839599609375,
-0.013004586100578308,
-0.011055294424295425,
-0.0028889793902635574,
-0.003685164265334606,
-0.015432337298989296,
0.015021244063973427,
0.015930280089378357,
-0.015228834934532642,
-0.010188889689743519,
-0.01116140466183424,
-0.01930263824760914,
-0.01318345032632351,
0.00019049469847232103,
-0.005575251299887896,
-0.006647906266152859,
-0.009531939402222633,
-0.04696325212717056,
0.0048599764704704285,
-0.0075692068785429,
0.007104710675776005,
-0.005450892262160778,
-0.004726283252239227,
-0.0016060338821262121,
-0.014181884005665779,
0.009945257566869259,
0.00539602804929018,
0.01504955068230629,
-0.028601955622434616
] | [
0.2801503837108612,
-0.14847713708877563,
0.6944615244865417,
-0.03401603549718857,
-0.4054577946662903,
0.010793207213282585,
0.2946726679801941,
-0.3871861398220062,
0.41149938106536865,
-0.5133304595947266,
0.13245077431201935,
0.38699036836624146,
-0.23821750283241272,
0.13520042598247528,
-0.42335063219070435,
0.9678280353546143,
-0.01462065614759922,
0.07075932621955872,
-0.2467130869626999,
-0.5899178385734558,
0.010432100854814053,
-0.3063119947910309,
0.2602556347846985,
-0.3332294821739197,
0.5029473900794983,
0.6750866770744324,
0.4273170828819275,
0.092689149081707,
0.02417699433863163,
0.32840481400489807,
0.20114338397979736,
0.16113470494747162,
-0.2740929424762726,
-0.19657395780086517,
-0.474183589220047,
0.04546811804175377,
-0.2722260057926178,
-0.12619663774967194,
0.2073971927165985,
-0.30222874879837036,
-0.1643984019756317,
-0.4987597167491913,
-0.4335843026638031,
0.6207268834114075,
-0.2979535460472107,
-0.33548569679260254,
-1.6662695407867432,
0.9480028748512268,
-0.4917442202568054,
0.18666225671768188,
-0.5601562857627869,
-0.05233302712440491,
0.33660832047462463,
-0.32383453845977783,
0.29329922795295715,
0.19148364663124084,
-0.5875435471534729,
-0.29469913244247437,
0.43078893423080444,
-0.3464108109474182,
-0.035640086978673935,
0.1409754455089569,
0.06146986410021782,
0.4950891435146332,
-0.22656549513339996,
0.6722049117088318,
-0.04487459734082222,
-0.46667057275772095,
-0.6680284738540649,
-0.2613924443721771,
0.6144883632659912,
0.19982260465621948,
-0.501190185546875,
0.49262481927871704,
-0.06784742325544357,
0.23701947927474976,
-0.6531384587287903,
-0.1952817142009735,
0.1935601830482483,
0.19565413892269135,
0.03934280946850777,
0.22593986988067627,
0.45254507660865784,
-0.02217552810907364,
0.34788164496421814,
-0.06869807839393616,
-0.29896554350852966,
0.9398754835128784,
-0.7411768436431885,
0.12123923003673553,
-0.30988961458206177,
-0.41013026237487793,
0.29940053820610046,
0.5701865553855896,
0.04056202247738838,
0.10557850450277328,
-0.3303419053554535,
0.05150715261697769,
-0.44270092248916626,
0.3530065715312958,
0.43475303053855896,
0.19871453940868378,
-0.18236364424228668,
-0.8302505016326904,
-0.44545698165893555,
-0.21222421526908875,
-0.6874862313270569,
-0.5052627921104431,
-0.5993543267250061,
-0.20407506823539734,
-0.754655122756958,
-0.22786100208759308,
-0.33081215620040894,
-0.01054700929671526,
0.40582039952278137,
0.14035910367965698,
0.7088079452514648,
-0.2217249870300293,
-0.22262974083423615,
0.32870572805404663,
-0.6564221978187561,
0.7369430661201477,
-0.0351884700357914,
0.3593614995479584,
0.14924609661102295,
0.2334846407175064,
-0.34962108731269836,
-0.1350916177034378,
-0.5125088691711426,
0.7996982932090759,
0.40204212069511414,
0.5164667963981628,
0.08340826630592346,
-0.03495626896619797,
0.004889372736215591,
-0.6239852905273438,
0.27818065881729126,
-0.21544873714447021,
0.22391964495182037,
-0.0032798582687973976,
-0.5415339469909668,
-0.06191633269190788,
-0.6521735191345215,
-0.6695111393928528,
-0.03310029208660126,
-0.37767335772514343,
-0.3304831087589264,
0.07126975804567337,
0.036477379500865936,
0.29496657848358154,
0.12338878214359283,
-0.5352961421012878,
-0.7075309753417969,
-0.3893498480319977,
0.13443750143051147,
-0.054934851825237274,
0.29115191102027893,
0.21951934695243835,
0.008948786184191704,
0.24250036478042603,
0.03649095445871353,
-0.03350638598203659,
-0.6188693046569824,
0.02087489329278469,
0.38767462968826294,
-0.37607061862945557,
0.5625427961349487,
0.32895615696907043,
0.1467200219631195,
-0.1483088731765747,
-0.16905266046524048,
-0.3179822564125061,
0.08898986876010895,
-0.34097766876220703,
-0.39586490392684937,
-0.08477991819381714,
-0.16842222213745117,
-0.4889133870601654,
-0.06415705382823944,
-0.15166562795639038,
-0.8287288546562195,
-0.21300944685935974,
0.11066272854804993,
0.14283376932144165,
0.529198408126831,
0.27420109510421753,
0.7216166257858276,
0.17866769433021545,
-0.26567840576171875,
0.03764334321022034,
-0.2773939073085785,
-0.21256142854690552,
0.9757973551750183,
-0.3867975175380707,
1.1668782234191895,
0.08441431820392609,
-0.3383013606071472,
1.468300700187683,
-0.007782612927258015,
0.37794750928878784,
-0.23740898072719574,
0.08590025454759598,
0.5932740569114685,
-0.5571247935295105,
-0.3637940585613251,
-0.17977555096149445,
-0.15524668991565704,
-0.03361465036869049,
-0.18560923635959625,
-0.06673265248537064,
0.4384101927280426,
-0.5853533744812012,
-0.6587619781494141,
0.2329195886850357,
0.1287730634212494,
-0.377237468957901,
0.32402876019477844,
-0.06199387088418007,
-0.05032333731651306,
-0.01655268296599388,
0.5766986608505249,
-0.5263970494270325,
0.23202857375144958,
0.426410436630249,
-0.43215492367744446,
0.6824901103973389,
0.06273490190505981,
0.6245049834251404,
0.5069447159767151,
-0.036341648548841476,
0.04423052817583084,
-0.8903353214263916,
0.25899049639701843,
-0.311826229095459,
0.020907502621412277,
0.08946322649717331,
0.02005622908473015,
0.048917561769485474,
0.46794605255126953,
-0.0074785263277590275,
0.038194701075553894,
0.6939010620117188,
-0.7726812362670898,
-0.354589581489563,
0.2860211431980133,
-0.17897842824459076,
-0.14166449010372162,
0.1316421627998352,
-0.410544753074646,
-0.1850806474685669,
-0.09262201189994812,
0.03445799648761749,
-0.2076043039560318,
-0.4294552803039551,
0.13316939771175385,
0.007088121958076954,
0.08932342380285263,
-0.353298544883728,
-0.22659575939178467,
-0.3758436441421509,
-0.26505550742149353,
-0.2590029835700989,
-0.13384515047073364,
-0.08234651386737823,
-0.06303700059652328,
-0.4973561763763428,
-0.25842374563217163,
-0.28702569007873535,
1.3670814037322998,
0.44441935420036316,
0.7638298869132996,
0.04414432495832443,
-0.5689193606376648,
-0.28590959310531616,
-0.188577339053154,
-0.7546167969703674,
0.3638140559196472,
0.3078543543815613,
-0.1959504634141922,
-0.4167207181453705,
0.2300904095172882,
0.015723250806331635,
1.1638153791427612,
-0.37015870213508606,
-0.7974115014076233,
-0.19613319635391235,
-0.14625822007656097,
-0.6155343055725098,
-0.7826732993125916,
-0.5547641515731812,
-0.10575023293495178,
0.4427083134651184,
-0.29681482911109924,
0.2175537347793579,
-0.3051256835460663,
0.25837188959121704,
0.1713392287492752,
0.18031038343906403,
0.8064465522766113,
-0.28851330280303955,
-0.3547670543193817,
0.20208758115768433,
-0.6079399585723877,
-0.1070714145898819,
-0.10690712183713913,
0.26166749000549316,
-0.23883844912052155,
0.04990118369460106,
-5.663782119750977,
0.1953311264514923,
-0.013281763531267643,
-0.366100013256073,
0.29553693532943726,
0.03899076208472252,
1.0877728462219238,
0.11946270614862442,
0.4315201938152313,
-0.1675560623407364,
0.22895114123821259,
0.15224048495292664,
0.15650616586208344,
-0.3788835406303406,
-0.13996587693691254,
0.0032088630832731724,
-0.15619850158691406,
0.04612718150019646,
0.6015886664390564,
-0.016184160485863686,
0.32080015540122986,
-0.5407070517539978,
0.041525062173604965,
0.6503494381904602,
-0.14178389310836792,
-0.048012521117925644,
-1.04013192653656,
-0.0408499650657177,
-0.16915453970432281,
-0.30252528190612793,
0.11724448949098587,
-0.48334336280822754,
-0.22855423390865326,
-0.005863215308636427,
0.0027904713060706854,
-0.16059455275535583,
0.4277958869934082,
-0.3748305141925812,
0.17984141409397125,
-0.39946243166923523,
0.5999626517295837,
-0.040169909596443176,
0.24989357590675354,
-0.44281846284866333,
0.3384445607662201,
-0.27716535329818726,
-0.35060977935791016,
-0.07890360057353973,
-0.3275153934955597,
0.47425732016563416,
-0.36922720074653625,
-0.3089194595813751,
0.23240940272808075,
0.3834260404109955,
0.2954498827457428,
-0.020380685105919838,
-0.18443544209003448,
-0.10959391295909882,
-0.7257505059242249,
0.2563800513744354,
-0.3115149736404419,
-0.35648995637893677,
-0.1792575567960739,
-1.221306562423706,
0.014330395497381687,
0.8235633373260498,
-0.2661123275756836,
-0.18768873810768127,
0.36227643489837646,
-0.05745682120323181,
-0.16496746242046356,
0.5069023370742798,
-0.6668334007263184,
-0.5791109204292297,
0.7316209077835083,
-0.36452972888946533,
0.47557878494262695,
0.3502444624900818,
-0.4911442697048187,
-0.21063201129436493,
-0.24687077105045319,
-0.3886256515979767,
-0.2316543012857437,
0.3270054757595062,
0.3326863646507263,
-0.4099714457988739,
-0.04491829499602318,
-0.40672802925109863,
0.03266353905200958,
0.08409634977579117,
0.6067644357681274,
-0.18153172731399536,
-0.1498483121395111,
0.35249823331832886,
-0.03770538046956062,
-0.634990930557251,
0.25981494784355164,
0.6545589566230774,
0.8160408735275269,
0.04927801340818405,
0.740456759929657,
-0.0714203342795372,
-0.007581235840916634,
-0.45097556710243225,
0.05445166304707527,
0.07587487995624542,
-0.5355066061019897,
0.21215809881687164,
0.6885339021682739,
-0.6391048431396484,
-0.3207431137561798,
-0.0652504414319992,
-0.6086496114730835,
0.4952624440193176,
0.5997200012207031,
-0.3839690387248993,
-0.005617517977952957,
0.22703640162944794,
0.674679160118103,
-0.25849372148513794,
-0.33239489793777466,
0.06465456634759903,
-0.06630954146385193,
0.24003353714942932,
0.4211321771144867,
-0.6994857788085938,
0.29571303725242615,
0.6517953872680664,
-0.5225226283073425,
-0.15555162727832794,
0.331537663936615,
0.4549713432788849,
-0.059888407588005066,
-0.34821489453315735,
-0.146145761013031,
-0.4154856204986572,
-0.5901482105255127,
-0.035276371985673904,
0.2794382870197296,
-0.06339792907238007,
0.5000653862953186,
-0.3256298005580902,
0.10386627167463303,
0.1841084510087967,
0.8931581974029541,
0.12971898913383484,
0.46747300028800964,
0.05180150642991066,
-0.5004626512527466,
-0.139548197388649,
0.4078200161457062,
-0.04663297161459923,
0.27533936500549316,
-0.26394009590148926,
0.6460615992546082,
0.7518936991691589,
0.5142518281936646,
0.2869531214237213,
0.10544416308403015,
-0.4921225607395172,
-0.09748529642820358,
0.7483455538749695,
-0.5362966656684875,
0.5623327493667603,
-0.600532591342926,
-0.5061644911766052,
-0.46145954728126526,
-0.07114636898040771,
-0.16387587785720825,
-0.09380293637514114,
-0.34014302492141724,
-0.04030808433890343,
0.18060673773288727,
0.0984749048948288,
-0.3857746422290802,
-0.23944596946239471,
-0.5663964152336121,
0.16083714365959167,
-0.2836449444293976,
0.2734290361404419,
-0.00985283125191927,
-0.1594119817018509,
0.02817484922707081,
0.6054030060768127,
0.4583575129508972,
0.15661361813545227,
-0.3824698328971863,
0.02430497668683529,
-0.21094341576099396,
-0.03831828758120537,
0.4523395597934723,
-0.05151006951928139,
-0.10351423174142838,
-0.2683113217353821,
-0.02726474031805992,
0.09581108391284943,
0.7573789954185486,
0.39098605513572693,
-0.042207732796669006,
-0.5883238911628723,
-0.03493352234363556,
0.5667116045951843,
-0.3167668282985687,
0.35688483715057373,
0.2727597653865814,
0.13987791538238525,
-0.09978033602237701,
0.3711055815219879,
-0.23585106432437897,
-0.3356296122074127,
-0.2538108825683594,
-0.7373062968254089,
0.7583725452423096,
0.24478712677955627,
-0.03727777302265167,
-0.13659974932670593,
0.05332162231206894,
-0.1638229638338089,
0.02835584245622158,
-0.050992392003536224,
0.523284912109375,
-0.2575492858886719,
0.526221752166748,
0.05222924053668976,
-0.6233200430870056,
-0.007580102887004614,
0.21365365386009216,
-0.4698154330253601,
0.06127234548330307,
0.22500644624233246,
0.536738395690918,
-0.30481764674186707,
0.06239268556237221,
0.4263715147972107,
-0.4295932650566101,
-0.35199329257011414,
-1.0990630388259888,
0.13270051777362823,
0.2072674185037613,
0.3430401384830475,
0.4515473246574402,
0.5375210642814636,
-0.33273953199386597,
0.24763000011444092,
0.21817290782928467,
0.4341597557067871,
-0.13861845433712006,
-0.46451979875564575,
-0.2130529284477234,
0.6152120232582092,
0.32534536719322205,
0.04615405574440956,
0.027496138587594032,
0.45808008313179016,
1.2142441272735596,
0.533238410949707,
-0.20657627284526825,
-0.367031991481781,
-0.3626396358013153,
0.47086232900619507,
-0.20531108975410461,
0.426658570766449,
-0.20387686789035797,
-0.09841589629650116,
-0.09388953447341919,
0.3124626576900482,
-0.2895715534687042,
-0.8484280705451965,
1.035114049911499,
0.024640709161758423,
-0.6040116548538208,
-0.219528928399086,
0.8681729435920715,
0.31015488505363464,
-0.6760749220848083,
0.2090734839439392,
0.10180197656154633,
0.41034552454948425,
-0.10514099895954132,
0.4218210279941559,
-0.28840431571006775,
-0.2615557312965393,
0.7491638660430908,
-0.19481679797172546,
0.06676691025495529,
-0.38597995042800903,
-0.21428900957107544,
-0.20738549530506134,
0.33094072341918945,
-0.24457699060440063,
-0.36127331852912903,
0.3105356693267822,
-0.5264148116111755,
-0.1551964432001114,
-0.0016182069666683674,
0.5388450026512146,
0.5124008059501648,
0.4727006256580353,
-0.27112874388694763,
0.3625149428844452,
-0.44298920035362244,
0.502886950969696,
0.7063936591148376,
-0.8244884610176086,
-0.34624654054641724,
0.13198687136173248,
0.4375062584877014,
0.35513773560523987,
-0.24732469022274017,
-0.3163648545742035,
-0.09820054471492767,
0.13915665447711945,
0.3845973610877991,
0.2657454311847687,
-0.268759161233902,
-0.16071690618991852,
-0.12127824127674103,
0.11888374388217926,
0.15894906222820282,
0.09566780924797058,
0.04043338820338249,
0.7994983792304993,
0.7371090650558472,
-0.023313812911510468,
-0.23603148758411407,
0.6771078705787659,
0.2937728762626648,
0.05448084697127342,
-0.14481864869594574,
0.9388361573219299,
0.23698395490646362,
-0.10585146397352219,
0.26191648840904236,
0.559293806552887,
0.49577194452285767,
-0.05386543646454811,
-0.01055934652686119,
0.038130443543195724,
-0.10737945884466171,
0.13271620869636536,
0.6096178293228149,
0.32743972539901733,
-0.32996833324432373,
-0.04311850294470787,
0.41962239146232605,
0.037029966711997986,
0.25572773814201355,
0.3093014359474182,
0.6771758198738098,
0.4116557538509369,
0.11173591017723083,
-0.41938820481300354,
-0.32033440470695496,
-0.10329460352659225,
-0.571357011795044,
0.06655067205429077,
0.48551174998283386,
0.012529740110039711,
-0.5675166249275208,
0.02989158034324646,
-0.7858428359031677,
0.1681188941001892,
0.2453702986240387,
0.5261477828025818,
-0.8007553219795227,
-0.07963355630636215,
0.8009169101715088,
0.38899335265159607,
0.398510605096817,
0.35043004155158997,
-0.03422417491674423,
0.13477927446365356,
-0.32008013129234314,
0.4651203453540802,
0.35138964653015137,
-0.4007006287574768,
0.45963147282600403,
-0.17493511736392975,
-0.300710529088974,
0.08033809065818787,
-0.1066989004611969,
0.15186965465545654,
0.14735925197601318,
-0.9922574162483215,
-0.4003393054008484,
-0.128301203250885,
-0.29486674070358276,
-0.16713283956050873,
0.12072942405939102,
-0.12280026823282242,
0.4676549434661865,
-0.45416802167892456,
0.4881453216075897,
-0.12928688526153564,
-0.1908639669418335,
-0.057428691536188126,
-0.44362080097198486,
0.21275506913661957,
0.1717805117368698,
0.5094043612480164,
-0.4047524034976959,
0.33351579308509827,
0.44203996658325195,
0.01804998703300953,
-0.2681921720504761,
0.5593048334121704,
-0.32356488704681396,
-0.10082189738750458,
-0.31975844502449036,
-0.5124961733818054,
1.2087759971618652,
0.7468643188476562,
-0.19572745263576508,
-0.057320475578308105,
-0.3617617189884186,
-0.3824886679649353,
0.14524228870868683,
-0.5523726940155029,
0.08708573877811432,
-0.35812461376190186,
-0.08304162323474884,
-0.3743589222431183,
0.37835636734962463,
0.457237184047699,
-0.15099558234214783,
0.008247041143476963,
0.5766369700431824,
0.48457932472229004,
-0.6142899394035339,
0.5323165655136108,
0.09662572294473648,
0.17011085152626038,
-0.08182375878095627,
-0.3106520473957062,
-0.4616551101207733,
0.1012563556432724,
-0.8969246745109558,
0.5162914991378784,
0.015262264758348465,
-0.12388879805803299,
0.3068624436855316,
-0.3874451816082001,
-0.6922906041145325,
-0.16884255409240723,
0.3749872148036957,
0.07574621587991714,
-0.37479138374328613,
-0.6018292903900146,
-0.7721697092056274,
-0.35405173897743225,
0.2095533162355423,
-0.4364713132381439,
0.14418934285640717,
0.03874347731471062,
-0.36775851249694824,
-0.16421490907669067,
0.07448972761631012,
-0.5679083466529846,
-0.2153627872467041,
0.14799247682094574
] |
A formula has been developed to predict creatinine clearance (Ccr) from serum creatinine (Scr) in adult males: (see article)(15% less in females). Derivation included the relationship found between age and 24-hour creatinine excretion/kg in 249 patients aged 18-92. Values for Ccr were predicted by this formula and four other methods and the results compared with the means of two 24-hour Ccr's measured in 236 patients. The above formula gave a correlation coefficient between predicted and mean measured Ccr's of 0.83; on average, the difference predicted and mean measured values was no greater than that between paired clearances. Factors for age and body weight must be included for reasonable prediction. | [
0.011171726509928703,
0.007976673543453217,
-0.042989809066057205,
0.02054877206683159,
-0.00042645458597689867,
0.0023638932034373283,
0.009319049306213856,
-0.03240841254591942,
-0.016240404918789864,
-0.037374429404735565,
0.012367566116154194,
0.005681589245796204,
0.01303919404745102,
0.006545583251863718,
-0.023128652945160866,
0.002834875602275133,
-0.016912197694182396,
0.011136908084154129,
0.015353197231888771,
0.003829758847132325,
0.023332828655838966,
-0.016215741634368896,
0.008997727185487747,
-0.027297060936689377,
-0.023166216909885406,
-0.0025687147863209248,
0.010277291759848595,
-0.009977530688047409,
0.00956643745303154,
-0.02778041735291481,
-0.010067364200949669,
-0.0311873871833086,
0.004622059874236584,
0.016175849363207817,
0.0240493081510067,
-0.005443510599434376,
-0.0023386904504150152,
0.018910706043243408,
0.002735045040026307,
-0.0035153180360794067,
-0.0007795644924044609,
-0.018587937578558922,
0.0113530857488513,
0.03552607074379921,
-0.008227390237152576,
0.00003453006502240896,
-0.014728263020515442,
0.01295115053653717,
-0.0008759959600865841,
0.010025648400187492,
-0.01466392632573843,
0.0008562665898352861,
-0.023549668490886688,
-0.011554224416613579,
-0.005517273209989071,
-0.0020120858680456877,
0.01835007593035698,
0.046007316559553146,
-0.005453940946608782,
-0.029191860929131508,
-0.0020947069860994816,
-0.030127257108688354,
0.010514402762055397,
-0.03396604210138321,
0.004087410867214203,
-0.06657770276069641,
-0.0020344213116914034,
0.03588356822729111,
-0.003654367756098509,
0.01978864148259163,
0.005283977836370468,
0.013602135702967644,
0.017403149977326393,
-0.03796564042568207,
0.005652741063386202,
0.008402669802308083,
-0.004619847051799297,
0.006060537416487932,
0.005929181352257729,
-0.033874981105327606,
-0.0025847293436527252,
-0.0015479461289942265,
-0.0001019197516143322,
0.014044101350009441,
0.0017834417521953583,
0.0035235723480582237,
0.005496414843946695,
-0.0005016443319618702,
0.03441285714507103,
0.009385126642882824,
-0.014875546097755432,
0.01810253970324993,
0.0006803146097809076,
0.010319449938833714,
-0.04189697280526161,
0.03596394509077072,
0.009728661738336086,
0.017671285197138786,
-0.020594995468854904,
-0.016095170751214027,
-0.012079637497663498,
-0.025289813056588173,
0.012138066813349724,
0.0017682095058262348,
-0.05558714270591736,
0.010201292112469673,
-0.001779492711648345,
0.01729222945868969,
-0.004804918076843023,
0.0013725587632507086,
-0.001150315161794424,
0.008639563806355,
-0.001726184505969286,
-0.031494636088609695,
0.017508435994386673,
0.03723491355776787,
-0.010256234556436539,
-0.0007390917744487524,
0.010561101138591766,
-0.01060713641345501,
-0.025729140266776085,
0.013358216732740402,
0.0052220141515135765,
-0.02194495126605034,
-0.004630934912711382,
0.002872058190405369,
-0.013626299798488617,
-0.0019252869533374906,
-0.0021372968330979347,
-0.004893495235592127,
-0.005469645839184523,
0.004614179953932762,
-0.017278626561164856,
-0.003239405108615756,
-0.01145884394645691,
-0.000005055044312030077,
0.024200890213251114,
-0.013736585155129433,
-0.02203083410859108,
-0.007044907659292221,
-0.019950957968831062,
0.003538611577823758,
0.003075418993830681,
0.01722591370344162,
0.016249770298600197,
-0.02018626220524311,
-0.009881413541734219,
0.00853952020406723,
0.013526229187846184,
-0.03940020129084587,
-0.023102328181266785,
-0.01007716916501522,
-0.02143225260078907,
-0.007586711086332798,
-0.0025893496349453926,
0.01178494468331337,
-0.008624804206192493,
0.00024934904649853706,
0.011767185293138027,
-0.01421385258436203,
-0.0010558178182691336,
0.02798302099108696,
0.025589561089873314,
0.008641891181468964,
0.001209435984492302,
-0.005617779679596424,
-0.002728806808590889,
0.008583633229136467,
-0.026706412434577942,
0.004498401656746864,
0.005503648892045021,
0.004328220151364803,
0.0026126056909561157,
0.006177103146910667,
0.008873510174453259,
-0.0026823419611901045,
-0.001094592036679387,
0.004126652143895626,
-0.004208417609333992,
0.06649976968765259,
0.003217887133359909,
0.03597039356827736,
-0.003090897109359503,
0.04600232094526291,
0.007944704964756966,
-0.01888497918844223,
0.007377097848802805,
-0.00851207971572876,
0.031162116676568985,
0.003336475230753422,
-0.0018619524780660868,
-0.023897483944892883,
0.008126886561512947,
-0.02267981693148613,
-0.01620067097246647,
0.004002912435680628,
0.008631153032183647,
0.012686299160122871,
0.0013643157435581088,
-0.013397326692938805,
0.018032195046544075,
0.013189882040023804,
0.042639028280973434,
0.021964598447084427,
-0.0022746119648218155,
-0.0017928450834006071,
0.026018980890512466,
-0.01573990471661091,
0.0016414416022598743,
-0.009355289861559868,
0.011048070155084133,
-0.018221179023385048,
0.024942271411418915,
-0.021324818953871727,
0.0073738400824368,
0.010312729515135288,
0.03161183372139931,
-0.0052499352023005486,
0.007071555592119694,
-0.019847244024276733,
0.015749679878354073,
-0.019916560500860214,
-0.020451726391911507,
-0.0007741886656731367,
0.01709930971264839,
-0.03831490874290466,
0.004210872109979391,
0.008342207409441471,
0.0037518045864999294,
0.005518559832125902,
-0.000798588152974844,
-0.0032818487379699945,
-0.008050035685300827,
0.003088599070906639,
0.008022156544029713,
-0.024165337905287743,
0.012148845940828323,
0.0042460085824131966,
0.007578098215162754,
-0.01627514138817787,
-0.015201371163129807,
0.0033645150251686573,
0.0056947385892271996,
-0.0019155375193804502,
0.0420336090028286,
0.014923391863703728,
0.008540729992091656,
-0.012877488508820534,
-0.0024230023846030235,
0.002131243236362934,
0.010015862993896008,
-0.007847676053643227,
0.0006706379354000092,
0.024374740198254585,
0.0032613377552479506,
-0.021048273891210556,
0.0046042753383517265,
0.0171081330627203,
0.025857120752334595,
0.013807524926960468,
0.019284145906567574,
0.005831860937178135,
0.02368062362074852,
0.010516306385397911,
-0.015850156545639038,
0.02743656374514103,
-0.0035473366733640432,
0.027972470968961716,
0.02830914407968521,
-0.0009853364899754524,
0.005238755140453577,
-0.01392056979238987,
-0.012346764095127583,
-0.08161558955907822,
-0.0015020505525171757,
-0.006230524275451899,
0.0024903910234570503,
0.004480699542909861,
0.028326882049441338,
0.010762256570160389,
0.0071144853718578815,
-0.002173013985157013,
0.021947991102933884,
0.007754588034003973,
-0.004549307748675346,
-0.004580948036164045,
0.03152009844779968,
0.019266510382294655,
-0.0035026692785322666,
0.002862496767193079,
-0.0066149430349469185,
-0.00941391196101904,
-0.010979019105434418,
-0.0034851767122745514,
-0.0004713861271739006,
0.0034948838874697685,
-0.003913064952939749,
0.03189318999648094,
-0.010852751322090626,
-0.0062013124115765095,
-0.002491191029548645,
-0.05255546793341637,
0.013182169757783413,
-0.011333923786878586,
-0.01868606172502041,
0.02690231427550316,
0.02499430626630783,
0.00021651433780789375,
0.001797296805307269,
-0.026821432635188103,
0.007214270532131195,
-0.014964061789214611,
0.027747169137001038,
-0.023560168221592903,
0.003858900861814618,
-0.003163149580359459,
0.002401500940322876,
-0.002965026069432497,
-0.0018246984109282494,
-0.007935808040201664,
0.04425269365310669,
0.018315432593226433,
-0.01541127823293209,
-0.0028236787766218185,
-0.0029387467075139284,
-0.006614865735173225,
0.012301989831030369,
-0.011682056821882725,
0.003952953033149242,
0.012702926993370056,
0.01452674251049757,
-0.012696124613285065,
-0.008145256899297237,
0.01219774130731821,
-0.00016211066395044327,
-0.011289656162261963,
0.013390985317528248,
0.01259315200150013,
0.010503875091671944,
-0.0005792952142655849,
0.00034946901723742485,
-0.02091122418642044,
0.001506394357420504,
-0.01707027666270733,
-0.01644391007721424,
-0.018708253279328346,
-0.009073697030544281,
-0.02118643745779991,
-0.01772041991353035,
-0.01863895170390606,
0.004142253194004297,
-0.012013089843094349,
-0.028242940083146095,
0.02039967104792595,
-0.0008408664725720882,
0.003962256014347076,
-0.0058045824989676476,
-0.01687971130013466,
0.0010564438998699188,
0.009786627255380154,
-0.011232811957597733,
0.02257152833044529,
-0.01636996679008007,
0.019596759229898453,
0.010446850210428238,
0.02668234333395958,
0.008533388376235962,
-0.014342076145112514,
-0.010157406330108643,
-0.01548630092293024,
-0.01424921303987503,
-0.0015576307196170092,
0.0075562456622719765,
-0.014177316799759865,
-0.014716209843754768,
-0.017368502914905548,
-0.007280437275767326,
-0.03425011783838272,
0.01131894625723362,
-0.0015547428047284484,
0.002875317819416523,
-0.010310576297342777,
-0.005037914961576462,
-0.020014841109514236,
-0.003914136905223131,
-0.013638487085700035,
0.024362601339817047,
0.0032674958929419518,
0.028589613735675812,
-0.015600405633449554,
0.006066525354981422,
0.07238997519016266,
0.004689219407737255,
0.015519204549491405,
-0.02125868946313858,
-0.0026212669909000397,
-0.020254403352737427,
0.015306614339351654,
-0.010036894120275974,
-0.009689683094620705,
0.010996033437550068,
0.012906084768474102,
0.041912391781806946,
-0.013358250260353088,
0.00672961724922061,
-0.038112662732601166,
0.009999740868806839,
0.0019513712031766772,
0.012812948785722256,
-0.007051666267216206,
0.001651622704230249,
-0.022231880575418472,
-0.009324891492724419,
-0.01505317259579897,
-0.018529046326875687,
0.010799005627632141,
-0.018219508230686188,
-0.010118337348103523,
-0.013076137751340866,
-0.012614335864782333,
0.012390234507620335,
0.015142328105866909,
0.01761636696755886,
-0.003848907072097063,
0.014155367389321327,
0.00036135350819677114,
-0.00787072628736496,
0.016022969037294388,
0.016188932582736015,
0.01303880475461483,
0.032252829521894455,
-0.015121668577194214,
-0.014001438394188881,
0.005011953413486481,
0.002522200345993042,
0.00040406803600490093,
0.00737304612994194,
0.018972767516970634,
-0.005272827111184597,
-0.012844105251133442,
-0.0008821559604257345,
-0.009166649542748928,
0.010474947281181812,
0.019145894795656204,
0.007293377537280321,
-0.01510489173233509,
0.0028141476213932037,
-0.0049622380174696445,
-0.001944705843925476,
-0.021065544337034225,
-0.03575851023197174,
-0.011861538514494896,
-0.016243483871221542,
-0.01552349142730236,
-0.02635708823800087,
-0.021063953638076782,
-0.014312447980046272,
0.010198834352195263,
-0.008920574560761452,
-0.0017292352858930826,
0.011898200958967209,
-0.010515734553337097,
-0.009251478128135204,
-0.013804960995912552,
-0.023455578833818436,
0.01844709739089012,
-0.039199285209178925,
0.0004672959912568331,
-0.01550155971199274,
-0.018818950280547142,
-0.009894930757582188,
0.012482739984989166,
0.026426831260323524,
0.003545832820236683,
-0.010957218706607819,
0.028346657752990723,
-0.0078115640208125114,
-0.014583253301680088,
-0.07526914775371552,
-0.03765014186501503,
0.021392449736595154,
-0.015163296833634377,
0.009113614447414875,
0.023880206048488617,
-0.019649120047688484,
0.007154908496886492,
-0.026824526488780975,
-0.007507619448006153,
0.007912742905318737,
0.0017418715870007873,
-0.0013327359920367599,
-0.010265741497278214,
0.012583749368786812,
-0.025586526840925217,
-0.03257704898715019,
0.01810232549905777,
0.010942094027996063,
0.007767540868371725,
-0.006317791063338518,
0.01737946644425392,
-0.0011794460006058216,
-0.011056859977543354,
0.0029086892027407885,
-0.08123257756233215,
-0.0010090675204992294,
0.001122412271797657,
0.012453291565179825,
-0.011384960263967514,
-0.0077367257326841354,
0.05793806537985802,
-0.006234678439795971,
0.00358842546120286,
-0.018620368093252182,
0.011316604912281036,
-0.01534147560596466,
-0.016471289098262787,
-0.018043512478470802,
-0.0026986217126250267,
-0.004950542002916336,
0.016515551134943962,
-0.011560977436602116,
-0.0024435739032924175,
0.018583837896585464,
0.008364265784621239,
0.024244364351034164,
-0.00467265211045742,
0.008724421262741089,
-0.008894536644220352,
-0.024514060467481613,
0.004207327030599117,
0.014385067857801914,
-0.008953702636063099,
-0.025486411526799202,
0.003786548739299178,
0.005098369903862476,
-0.016499318182468414,
0.0025323592126369476,
0.021530017256736755,
-0.006377998273819685,
-0.020764414221048355,
-0.03423493355512619,
0.007538190111517906,
0.008919699117541313,
-0.00237811217084527,
-0.02587716653943062,
0.036150697618722916,
-0.004459073767066002,
0.002873244695365429,
-0.005496911704540253,
0.005688074044883251,
-0.01466788537800312,
0.007932065986096859,
-0.02815379947423935,
0.02002429962158203,
-0.005930599756538868,
-0.0030276370234787464,
0.01411264669150114,
0.013708728365600109,
0.012129904702305794,
-0.008983829990029335,
-0.014816338196396828,
-0.00996022392064333,
-0.003469318151473999,
-0.01218598335981369,
0.00544432457536459,
-0.011648020707070827,
0.0714959129691124,
-0.022016584873199463,
0.00484060775488615,
0.003978795371949673,
-0.023972291499376297,
-0.0015362587291747332,
0.005395198240876198,
-0.02118753269314766,
-0.02628290094435215,
-0.007629361469298601,
-0.012083406560122967,
-0.00853577721863985,
0.01371405553072691,
0.010412356816232204,
-0.009213700890541077,
0.010171724483370781,
-0.003878324292600155,
0.016572557389736176,
-0.03720040246844292,
0.03215912729501724,
0.002610399154946208,
0.022461501881480217,
0.0013474985025823116,
0.011061912402510643,
0.006535131484270096,
0.0017286993097513914,
0.026177680119872093,
0.016670847311615944,
0.0019681467674672604,
0.046401169151067734,
-0.005180777981877327,
-0.022854037582874298,
0.013754255138337612,
-0.009131224825978279,
0.010401997715234756,
-0.016421975567936897,
-0.004717896692454815,
0.008233906701207161,
-0.019787956029176712,
-0.010813887231051922,
0.021845554932951927,
-0.0275129321962595,
-0.0009403896983712912,
-0.04125247150659561,
0.012030834332108498,
-0.019830118864774704,
0.007117784582078457,
0.03242512047290802,
-0.015805397182703018,
0.02144709974527359,
0.020180877298116684,
0.003052016254514456,
-0.014668093994259834,
0.00434489082545042,
-0.005108392331749201,
-0.04385692626237869,
-0.0005630068480968475,
0.018886391073465347,
0.035378459841012955,
0.009693368338048458,
-0.009394235908985138,
-0.010581721551716328,
0.005379997193813324,
-0.017183547839522362,
0.021336063742637634,
-0.016369309276342392,
-0.013885053806006908,
-0.0031783366575837135,
0.014386634342372417,
0.012367300689220428,
-0.0243076104670763,
0.04764702916145325,
0.006508778315037489,
0.009583016857504845,
0.012377668172121048,
0.030283452942967415,
0.02208498865365982,
0.00539049319922924,
0.02229553647339344,
0.020067116245627403,
-0.01907600462436676,
0.03976834565401077,
-0.006310774013400078,
-0.03040989860892296,
-0.006988878827542067,
0.003209263551980257,
-0.002914643846452236,
0.012270735576748848,
-0.011189939454197884,
-0.002559653017669916,
0.02660040743649006,
0.013885939493775368,
0.003283802419900894,
0.002996064256876707,
0.006072427146136761,
0.03524797409772873,
0.004088161513209343,
0.004326965194195509,
0.01205659843981266,
-0.008272061124444008,
-0.00602373480796814,
0.014175424352288246,
-0.0006071189418435097,
0.006323218811303377,
0.020958300679922104,
-0.004606957081705332,
-0.024109531193971634,
0.029141344130039215,
0.020207565277814865,
0.024949414655566216,
0.00914335809648037,
-0.034589625895023346,
0.031247282400727272,
-0.0038631041534245014,
-0.006240484304726124,
0.00967043824493885,
0.010997428558766842,
-0.005990469828248024,
-0.006494168192148209,
-0.008356756530702114,
0.0006693918257951736,
-0.021770168095827103,
-0.031663667410612106,
0.01133720763027668,
-0.006654676515609026,
-0.019840821623802185,
-0.0027949316427111626,
0.002459915354847908,
0.025697117671370506,
-0.030564719811081886,
0.028243770822882652,
0.028779251500964165,
-0.012314043939113617,
-0.016568325459957123,
-0.010853299871087074,
-0.02363770455121994,
-0.009419105015695095,
-0.024466823786497116,
-0.0038366196677088737,
-0.008230950683355331,
0.03402649611234665,
-0.0060448599979281425,
-0.0010666989255696535,
-0.014971313998103142,
0.0075979083776474,
0.007235732860863209,
-0.02687513828277588,
0.02079794369637966,
-0.0007200752734206617,
-0.021676894277334213,
0.011160986497998238,
0.020030682906508446,
0.0067778080701828,
-0.0028292301576584578,
-0.00859437882900238,
0.00007840641774237156,
0.02411668375134468,
0.007132047787308693,
0.004075510427355766,
-0.0015754189807921648,
-0.007295605726540089,
-0.023911479860544205,
0.007343578152358532,
0.025836773216724396,
-0.0014915927313268185,
0.023737911134958267,
0.002960149897262454,
-0.00860836636275053,
-0.0002863416448235512,
-0.03541884198784828,
0.004911588504910469,
0.015268105082213879,
-0.0032926856074482203,
0.026626314967870712,
0.007092465180903673,
-0.0040459539741277695,
-0.01931026205420494,
0.01495441049337387,
-0.02330927923321724,
0.013591340743005276,
-0.0022486764937639236,
-0.031579792499542236,
0.009326966479420662,
-0.01047060638666153,
0.011593748815357685,
0.010211465880274773,
-0.010261119343340397,
0.005882461555302143,
-0.00458140391856432,
0.005297972820699215,
-0.01033702865242958,
0.006258539855480194,
-0.015992479398846626,
0.025053251534700394,
-0.012418859638273716,
0.03272029757499695,
0.024526353925466537,
0.018601499497890472,
-0.00356584251858294,
-0.002563046757131815,
0.004880158230662346,
-0.01494504977017641
] | [
0.6288415789604187,
0.17973507940769196,
0.46913740038871765,
0.14562062919139862,
-0.15466274321079254,
0.2103738933801651,
0.35066407918930054,
-0.5407522916793823,
-0.4685610234737396,
-0.04840775579214096,
0.12107177078723907,
0.43009835481643677,
0.13206250965595245,
0.44691672921180725,
0.35880985856056213,
1.011810302734375,
0.483816534280777,
0.5947052836418152,
-0.09548556804656982,
-0.8173574209213257,
-0.25775521993637085,
-0.49859845638275146,
0.4575662314891815,
-0.20300249755382538,
-0.1953783482313156,
0.1353255808353424,
0.32256069779396057,
-0.164821594953537,
-0.06692441552877426,
-0.17368818819522858,
0.14469464123249054,
0.7168766260147095,
0.391905277967453,
-0.27655094861984253,
0.2988806962966919,
-0.11336931586265564,
-0.09502343833446503,
-0.20095133781433105,
-0.06560337543487549,
-0.7335138320922852,
-0.027808891609311104,
-0.1621808409690857,
-0.06209224462509155,
0.22885750234127045,
-0.5478698015213013,
-0.14580953121185303,
-0.8245806694030762,
0.1454915851354599,
-0.12098809331655502,
0.22912922501564026,
-0.07275841385126114,
0.48107171058654785,
0.28422752022743225,
-0.06605394184589386,
-0.08397824317216873,
0.18040187656879425,
-0.6923041343688965,
0.08118343353271484,
0.027735279873013496,
-0.33082666993141174,
0.382165789604187,
-0.20023880898952484,
0.26562774181365967,
0.37285730242729187,
-0.26557406783103943,
0.09226898849010468,
0.020495155826210976,
0.015900637954473495,
-0.2295401394367218,
0.20876847207546234,
0.11382613331079483,
-0.14942485094070435,
-0.17372192442417145,
0.07789479196071625,
-0.45650798082351685,
0.7318577170372009,
-0.24656815826892853,
-0.3504479229450226,
0.44174742698669434,
-0.24753330647945404,
0.0174571480602026,
-0.2267107516527176,
0.22669947147369385,
-0.28171414136886597,
0.3734360635280609,
0.33217355608940125,
0.2848281264305115,
0.5813602805137634,
-0.00839304644614458,
0.48218169808387756,
-0.39386504888534546,
0.19560900330543518,
0.3653605580329895,
0.2336033433675766,
0.0160907581448555,
0.08979710936546326,
0.03346027433872223,
-0.20363849401474,
-0.024440346285700798,
-0.35060060024261475,
0.4235380291938782,
0.08955202996730804,
-0.15052248537540436,
-0.016570527106523514,
-0.4625140428543091,
-0.17486241459846497,
-0.40943804383277893,
-0.5742725133895874,
-0.11198366433382034,
0.044780340045690536,
-0.6032924652099609,
0.07157894968986511,
0.06240322068333626,
-0.07318229228258133,
-0.10289871692657471,
-0.11896975338459015,
0.20047087967395782,
0.1711716502904892,
0.46493709087371826,
0.35917672514915466,
-0.8348513841629028,
0.48216864466667175,
0.13873136043548584,
-0.05875561758875847,
0.29795199632644653,
0.05738837644457817,
0.344957560300827,
0.037552155554294586,
-0.21592894196510315,
0.26616743206977844,
0.1856430321931839,
0.48074907064437866,
0.12089495360851288,
-0.18444576859474182,
-0.35065653920173645,
-0.48835188150405884,
-0.12136321514844894,
0.17284581065177917,
0.43685734272003174,
0.30850109457969666,
-0.03759143874049187,
-0.8238615989685059,
-0.3082650303840637,
-0.06158768758177757,
0.04541860148310661,
-0.4481305181980133,
0.040145669132471085,
0.06164474040269852,
-0.37423262000083923,
0.24478048086166382,
0.20911775529384613,
0.18679234385490417,
-0.14664967358112335,
-0.8919652700424194,
0.3045065402984619,
0.26055604219436646,
-0.4699499011039734,
0.11533133685588837,
-0.13541020452976227,
-0.35369983315467834,
0.4439341723918915,
0.4098756015300751,
-0.5022929906845093,
-0.25085267424583435,
0.7301157712936401,
-0.2594539523124695,
-0.18486100435256958,
0.16051965951919556,
-0.416202574968338,
0.13834957778453827,
-0.10829146206378937,
-0.09091220796108246,
-0.12946689128875732,
-0.6732407808303833,
-0.3082904815673828,
0.2554204761981964,
0.07228661328554153,
0.5647087097167969,
0.38155919313430786,
-0.02722398191690445,
-0.49222254753112793,
0.21170876920223236,
-0.21560566127300262,
-0.27203190326690674,
0.37515342235565186,
0.2743532955646515,
0.41771823167800903,
-0.2543450891971588,
-0.16570697724819183,
0.10737001150846481,
-0.17302095890045166,
-0.17538325488567352,
0.6803895235061646,
-0.6313555240631104,
1.1806350946426392,
-0.24023334681987762,
0.1470225602388382,
0.8576244115829468,
-0.3326698839664459,
-0.19833306968212128,
-0.35959818959236145,
0.29494547843933105,
0.6113581657409668,
-0.3795124292373657,
-1.1191978454589844,
0.01296511385589838,
-0.02072850801050663,
-0.11405301839113235,
-0.5200709700584412,
0.21691782772541046,
0.17697860300540924,
-0.41380900144577026,
-0.21200081706047058,
-0.41259679198265076,
0.04474852234125137,
0.030992645770311356,
0.05307828634977341,
0.023740852251648903,
0.11130065470933914,
0.06821390241384506,
0.315721720457077,
-0.498168021440506,
0.12707076966762543,
0.8632045388221741,
-0.36168986558914185,
0.44533661007881165,
0.5775889158248901,
0.46099165081977844,
0.5914498567581177,
-0.9475935101509094,
0.20606422424316406,
0.01835370995104313,
0.3791271448135376,
0.056079864501953125,
0.04678066447377205,
0.08625315874814987,
-0.06313955783843994,
-0.3119527995586395,
-0.017471525818109512,
0.17452207207679749,
-0.17960591614246368,
-0.06368598341941833,
-0.2042628973722458,
0.566221296787262,
0.14231428503990173,
-0.08406247943639755,
-0.31156137585639954,
0.6034743785858154,
-0.5819188356399536,
0.4074995517730713,
0.22820629179477692,
0.7415485978126526,
0.0851307362318039,
-0.061116866767406464,
0.005391676910221577,
-0.17477834224700928,
0.18264606595039368,
-0.6493046879768372,
-0.07257239520549774,
-0.24415893852710724,
-0.18488354980945587,
0.3072546720504761,
0.2047053724527359,
0.07376718521118164,
-0.07172844558954239,
-0.4812679886817932,
-1.404758095741272,
-0.5422033071517944,
0.26284512877464294,
0.45241713523864746,
0.3211216628551483,
0.0814802497625351,
-0.5792874693870544,
0.22250568866729736,
0.3400530219078064,
-0.24633149802684784,
0.4286653697490692,
0.223184734582901,
-0.6218001246452332,
-0.3399975597858429,
0.24973954260349274,
0.053476732224226,
0.7748745679855347,
0.06029769405722618,
-0.03301076963543892,
-0.3094223737716675,
-0.36580759286880493,
-0.2973639667034149,
0.17099310457706451,
-0.7145760655403137,
-0.15769685804843903,
0.6914769411087036,
0.2352934032678604,
-0.04795921593904495,
0.3007781505584717,
0.09901023656129837,
-0.45555293560028076,
0.5914435386657715,
0.7247667908668518,
-0.19490475952625275,
0.14972034096717834,
0.22781412303447723,
0.00444286921992898,
-0.13028846681118011,
0.04194136708974838,
-0.13824881613254547,
-0.2688194513320923,
0.03287964314222336,
-6.11562442779541,
0.3102709650993347,
-0.6382737159729004,
0.10054957866668701,
-0.3638584017753601,
0.06736665964126587,
1.0711342096328735,
-0.6344605088233948,
-0.5439923405647278,
0.19817587733268738,
0.12929490208625793,
0.2643909454345703,
0.1372811645269394,
0.4065549373626709,
0.2685283124446869,
0.4342379868030548,
0.416382372379303,
-0.3512822091579437,
0.09240303188562393,
0.0598880797624588,
0.45764702558517456,
-0.13615861535072327,
-0.15653830766677856,
0.14214813709259033,
0.3774382472038269,
0.2021988183259964,
-0.6320348978042603,
-0.2532596290111542,
-0.7420012950897217,
-0.07705573737621307,
-0.3762994110584259,
0.04164501279592514,
-0.35211414098739624,
0.09071896970272064,
0.47079724073410034,
-0.1292579174041748,
0.24608668684959412,
-0.04240800440311432,
0.020860133692622185,
-0.1864739954471588,
-0.17542563378810883,
0.24683044850826263,
0.36535972356796265,
0.04843444749712944,
0.12805646657943726,
0.2647153437137604,
0.017258627340197563,
-0.26246216893196106,
-0.21950918436050415,
0.6046336889266968,
-0.053501732647418976,
-0.4574294686317444,
0.12826691567897797,
0.03836400434374809,
-0.13820002973079681,
-0.04083390533924103,
0.140221506357193,
0.31751805543899536,
-0.4274100959300995,
0.27364879846572876,
-0.421705037355423,
-0.03243357688188553,
0.391719788312912,
-0.5982436537742615,
-0.2777029275894165,
0.1297093629837036,
-0.9839081764221191,
-0.6306902766227722,
0.35816118121147156,
0.505426824092865,
-0.42810001969337463,
0.3547917604446411,
0.01563815027475357,
-0.6737531423568726,
0.057336658239364624,
-0.5608581304550171,
0.11510308086872101,
0.6620370745658875,
-0.08885969966650009,
0.03643038868904114,
-0.0880078598856926,
-0.16990946233272552,
0.10805892199277878,
0.35677528381347656,
-0.10957660526037216,
-0.21695928275585175,
0.028102213516831398,
-0.07792200893163681,
0.023869620636105537,
0.25390616059303284,
0.08578518778085709,
-0.29945293068885803,
0.242365300655365,
0.35630926489830017,
-0.04171526059508324,
-0.019747598096728325,
0.5120213627815247,
0.4335513412952423,
0.25427740812301636,
-0.2194167673587799,
0.6670591235160828,
-0.16256442666053772,
-0.27817559242248535,
-0.8246914744377136,
-0.577979564666748,
0.2838532626628876,
-0.3325837552547455,
0.08700034767389297,
0.4136406183242798,
-0.7373754382133484,
0.13309134542942047,
-0.34395870566368103,
0.008134088478982449,
-0.0244151558727026,
0.6941527128219604,
-0.3314087986946106,
-0.22879280149936676,
0.04712597653269768,
0.3270639479160309,
-0.2208583652973175,
0.503825843334198,
0.4363824427127838,
-0.7680013179779053,
0.012986920773983002,
-0.3058532476425171,
-0.4729999899864197,
0.3412560820579529,
0.4387594163417816,
-0.7343645691871643,
0.1098627820611,
-0.35008230805397034,
0.3810427486896515,
-0.07165765017271042,
-0.2130889892578125,
0.17542296648025513,
-0.5439183115959167,
-0.44031456112861633,
0.48864829540252686,
0.18733559548854828,
0.1515660583972931,
0.5372594594955444,
0.18967731297016144,
-0.11975037306547165,
-0.07069068402051926,
-0.030492044985294342,
-0.018294455483555794,
0.05314213037490845,
-0.13098782300949097,
-0.23272569477558136,
-0.13242457807064056,
0.24087072908878326,
-0.5031236410140991,
0.4258545935153961,
0.23252397775650024,
-0.2583349943161011,
-0.3803142011165619,
0.33994704484939575,
0.542488694190979,
-0.017883069813251495,
-0.6737679243087769,
0.3176381587982178,
-0.018694868311285973,
-1.3349343538284302,
-0.29415783286094666,
0.28144997358322144,
-0.042959630489349365,
-0.21746376156806946,
-0.05614336207509041,
0.012108181603252888,
0.6757831573486328,
-0.23541928827762604,
-0.3011319041252136,
-0.5497124791145325,
-0.015994850546121597,
0.02715088054537773,
0.4234214425086975,
-0.011575917713344097,
-0.22138597071170807,
0.1303538978099823,
0.06605058163404465,
0.018209053203463554,
-0.44033029675483704,
-0.13841040432453156,
0.11267049610614777,
0.3608386516571045,
0.35084280371665955,
-0.42132672667503357,
0.09792866557836533,
-0.042369741946458817,
0.23765631020069122,
0.7989548444747925,
-0.0020727738738059998,
0.1277778595685959,
-0.1652814894914627,
-0.2465791404247284,
-0.10669155418872833,
0.06873845309019089,
0.810547947883606,
-0.20430752635002136,
0.3525194227695465,
0.08317209035158157,
0.451041579246521,
-0.023873986676335335,
0.357219398021698,
0.5545210838317871,
0.035510577261447906,
-0.24703353643417358,
0.12947507202625275,
-0.8436960577964783,
-0.3232887387275696,
-0.38518229126930237,
-0.21104760468006134,
-0.3622656464576721,
-0.1798437237739563,
-0.22543209791183472,
0.15173207223415375,
0.1203908771276474,
-0.37756577134132385,
-0.08868497610092163,
0.07188189029693604,
0.23517994582653046,
0.020000634714961052,
-0.32793962955474854,
-0.1509227603673935,
-0.38884639739990234,
0.2663711905479431,
0.21729953587055206,
-0.5299517512321472,
-0.09484437108039856,
0.42419934272766113,
-0.5907461047172546,
-0.05209366977214813,
0.35676446557044983,
-0.04294363781809807,
-0.2121281921863556,
-0.5777077674865723,
-0.25595325231552124,
0.3587646484375,
-0.2598848044872284,
-0.022378798574209213,
-0.3194897472858429,
0.502063512802124,
-0.05361980199813843,
-0.24522332847118378,
-0.01744062267243862,
0.31796330213546753,
0.4646531045436859,
-0.8144013285636902,
-0.3546975255012512,
0.2284594476222992,
0.4140898585319519,
-0.5062902569770813,
0.10987295210361481,
0.03811293840408325,
0.4053853154182434,
0.6041322350502014,
0.05036958307027817,
-0.3547302186489105,
0.18223443627357483,
0.43829864263534546,
-0.27761656045913696,
0.40704309940338135,
-0.3527168035507202,
0.06647508591413498,
0.09498324245214462,
0.5058873295783997,
-0.14987507462501526,
-0.3873690962791443,
0.18044669926166534,
-0.22934652864933014,
0.5046759247779846,
-0.11751672625541687,
0.5683448314666748,
0.8248800039291382,
0.41392406821250916,
0.1294867843389511,
-0.5822383165359497,
0.2172396332025528,
0.1926572024822235,
-0.11819460242986679,
-0.13951317965984344,
-0.4194684326648712,
0.3664148449897766,
0.2311602234840393,
0.30833834409713745,
0.02593788504600525,
-0.32078486680984497,
0.020384911447763443,
-0.2643589377403259,
0.07152742892503738,
-0.22453130781650543,
0.1139695793390274,
-0.5653721690177917,
-0.2617799639701843,
-0.007471541874110699,
0.06021236255764961,
0.19567246735095978,
0.554366946220398,
0.04719021916389465,
-0.039237525314092636,
-0.018434371799230576,
0.349637508392334,
0.9142367243766785,
-0.20988880097866058,
0.29351213574409485,
0.006435736548155546,
0.20041510462760925,
-0.19755138456821442,
-0.2835657596588135,
-0.1724380999803543,
0.5535797476768494,
-0.13576821982860565,
0.25681689381599426,
0.1642037034034729,
-0.6550012230873108,
-0.4031563401222229,
-0.10931072384119034,
0.10806727409362793,
0.3110724091529846,
0.46545612812042236,
0.2842749357223511,
0.6988353729248047,
0.7695925235748291,
-0.023465951904654503,
-0.28407853841781616,
0.35244059562683105,
0.0172465480864048,
-0.07615917921066284,
0.21109136939048767,
0.6164280772209167,
0.3146419823169708,
0.3230974078178406,
-0.41081440448760986,
0.6439396142959595,
0.3695443570613861,
-0.08721427619457245,
-0.2211558073759079,
-0.462543785572052,
-0.18270812928676605,
0.011004872620105743,
0.9055442810058594,
0.18787972629070282,
-0.284890741109848,
0.17960123717784882,
0.2029544711112976,
0.4771064519882202,
0.02842564880847931,
-0.46137693524360657,
0.35121384263038635,
0.20246611535549164,
0.46739572286605835,
-0.21705295145511627,
-0.15213873982429504,
0.07232607156038284,
-0.33524468541145325,
0.5609452128410339,
0.1604115068912506,
-0.239874929189682,
-0.8260313272476196,
0.2911953032016754,
-0.60585618019104,
0.059905171394348145,
-0.1610134243965149,
0.03681930899620056,
-0.08547184616327286,
-0.3430989384651184,
0.33385971188545227,
0.6992225050926208,
-0.4901069104671478,
0.030836710706353188,
-0.41182616353034973,
-0.17688550055027008,
-0.6064122915267944,
0.05431423336267471,
0.34116870164871216,
-0.7316045761108398,
-0.18841859698295593,
0.13939382135868073,
-0.16000056266784668,
0.02715045027434826,
-0.44423097372055054,
0.3965129554271698,
-0.090256467461586,
-0.3195917308330536,
-0.28314825892448425,
0.3777102530002594,
-0.17001120746135712,
0.029097435995936394,
0.15268075466156006,
0.027622709050774574,
0.24316568672657013,
-0.381819486618042,
-0.3327561020851135,
0.1661514937877655,
-0.0922030583024025,
-0.25281789898872375,
-0.4113021492958069,
0.3592810034751892,
0.5154950618743896,
-0.13748224079608917,
-0.423150897026062,
-0.30549848079681396,
-0.8326970934867859,
0.35003891587257385,
-0.22411583364009857,
0.4145560562610626,
-0.565840482711792,
0.1600000560283661,
-0.22689124941825867,
0.20999182760715485,
0.3194097876548767,
0.15120522677898407,
-0.523820698261261,
0.5739913582801819,
-0.309760719537735,
0.049824345856904984,
0.7153058052062988,
-0.488003134727478,
-0.31059470772743225,
-0.7122097611427307,
-0.4683409631252289,
0.0545775480568409,
0.6382097601890564,
-0.17270219326019287,
0.24728083610534668,
0.15869289636611938,
0.20000173151493073,
0.015399070456624031,
-0.21723736822605133,
0.2007075399160385,
-0.4192626178264618,
-0.08178596943616867,
-0.5619076490402222,
0.5897664427757263,
-0.6059049367904663,
0.0995476096868515,
0.33508074283599854,
0.09243931621313095,
-0.02764775976538658,
0.24105633795261383,
-0.1289108395576477,
-1.0134639739990234,
0.05910472571849823,
-0.34743285179138184,
0.22766630351543427,
-0.05775557458400726,
-0.038615886121988297,
-0.27068591117858887,
-0.33648720383644104,
0.18415014445781708,
0.050223786383867264,
-0.16102416813373566,
-0.3625718057155609,
-0.19012850522994995,
0.11806263029575348,
-0.48116734623908997,
-0.6215363144874573,
-0.1481378972530365,
0.2646302878856659,
0.06761541217565536
] |
Immune cells continuously recirculate through lymph vessels en route from peripheral tissues to the blood. Leuyte trafficking into and within lymph vessels is mediated by an interply with lymphatic endothelial cells (LECs). However, lymphatic vessels are much more than mere conduits for fluid and immune cell transport. Data accumulating during past several years indicate that LECs support T cell survival, induce tolerance to self-antigens, inhibit exaggerated T cell proliferation during immune response and maintain T cell memory. Reciprocally, leukocytes impact LEC biology: lymphatic vessel permeability depends on DCs while lymphocytes regulate LEC proliferation during inflammation. Altogether, these novel results provide important insights on intimate connections between LECs and leukocytes that contribute to the understanding of immune responses. | [
0.0001238510012626648,
-0.004182140342891216,
-0.017670482397079468,
0.006550134625285864,
0.009057153947651386,
0.004409193992614746,
0.011961010284721851,
0.006080488208681345,
-0.012580547481775284,
-0.007982952520251274,
-0.004304129164665937,
0.010677925311028957,
-0.014872068539261818,
0.012895877473056316,
-0.007636860944330692,
0.05240761488676071,
-0.026040900498628616,
-0.001621702336706221,
0.009531134739518166,
-0.00795610249042511,
-0.017464477568864822,
0.012741390615701675,
0.010200542397797108,
-0.024942461401224136,
-0.013426965102553368,
-0.0067934151738882065,
-0.012116096913814545,
-0.012902404181659222,
-0.001075154636055231,
-0.030551651492714882,
0.023367274552583694,
0.004841221030801535,
0.013567446731030941,
-0.010929722338914871,
-0.011148198507726192,
0.00022716959938406944,
-0.009521044790744781,
0.021819401532411575,
0.029745163396000862,
-0.0030796118080615997,
0.021201806142926216,
-0.005111285485327244,
0.003393515944480896,
0.00805724784731865,
-0.007155002560466528,
0.0015950861852616072,
-0.0011813145829364657,
-0.0015351376496255398,
-0.01669369824230671,
0.0042914096266031265,
-0.004529999569058418,
-0.02294512465596199,
-0.000015257333870977163,
-0.014581946656107903,
-0.007091845851391554,
-0.009982102550566196,
0.019055210053920746,
-0.013764627277851105,
0.010520294308662415,
0.005113741848617792,
-0.000132458982989192,
-0.027527328580617905,
-0.01128946803510189,
0.004831128753721714,
0.006712784990668297,
-0.06700251251459122,
-0.0031064082868397236,
0.0027800374664366245,
-0.0014165532775223255,
-0.01110636442899704,
-0.014200825244188309,
0.006814565509557724,
-0.014897922053933144,
-0.0007082183146849275,
-0.005868939682841301,
-0.017704740166664124,
-0.010615609586238861,
0.025903256610035896,
-0.005603194236755371,
0.026779714971780777,
0.01413632370531559,
-0.0013535611797124147,
0.01331155002117157,
0.027146974578499794,
0.019674312323331833,
-0.005124751478433609,
-0.0026899471413344145,
0.004781450144946575,
0.005519547034054995,
-0.02489474229514599,
-0.032442450523376465,
0.00421648845076561,
-0.04692820832133293,
0.008233582600951195,
0.005450855474919081,
-0.011236673220992088,
-0.01811446249485016,
-0.012857851572334766,
-0.015100056305527687,
-0.003284736070781946,
-0.011156229302287102,
0.009860542602837086,
0.015525875613093376,
0.026349641382694244,
0.010842617601156235,
0.009206967428326607,
-0.020978732034564018,
-0.02219133824110031,
0.008151452988386154,
0.013645187951624393,
-0.006746264174580574,
-0.0006320239044725895,
0.0000742906704545021,
0.03221471607685089,
-0.006848291493952274,
0.003753376193344593,
-0.012554692104458809,
0.003789410926401615,
0.014356201514601707,
-0.021134305745363235,
-0.027125274762511253,
-0.0017984779551625252,
0.0033659168984740973,
0.005372519604861736,
0.005952227395027876,
-0.0012279399670660496,
-0.006135161034762859,
0.022956524044275284,
0.0043905447237193584,
-0.009814471006393433,
-0.006726031191647053,
0.007524837739765644,
0.047094617038965225,
-0.0013897011522203684,
-0.005333990789949894,
0.0037933802232146263,
-0.0039341263473033905,
-0.008877190761268139,
-0.01030932366847992,
-0.02851749211549759,
-0.012644011527299881,
0.00843612290918827,
0.006118355318903923,
0.016801457852125168,
0.006109821144491434,
0.0030622147023677826,
-0.02063979208469391,
-0.0011407668935135007,
-0.024727066978812218,
0.0010286248289048672,
-0.0000321180559694767,
0.012670500203967094,
0.005287883337587118,
-0.02066429704427719,
-0.012913227081298828,
0.03515657037496567,
-0.020450744777917862,
-0.01072012446820736,
0.003772243857383728,
-0.007611960172653198,
-0.041055869311094284,
-0.016628172248601913,
0.03027689829468727,
0.011467136442661285,
0.03290195390582085,
-0.0071797058917582035,
0.006119200494140387,
-0.006902271881699562,
0.024925269186496735,
0.0067206257954239845,
-0.011913886293768883,
0.030361566692590714,
-0.015750885009765625,
0.010578682646155357,
-0.012744947336614132,
-0.004257231019437313,
0.0007699527777731419,
0.00793210044503212,
-0.002477498259395361,
0.06664527952671051,
0.014035895466804504,
0.012884114868938923,
0.00205403589643538,
-0.01803065650165081,
0.0011523040011525154,
-0.000005953479558229446,
0.0319366529583931,
-0.006979409139603376,
0.013591310940682888,
-0.021553516387939453,
-0.015021906234323978,
-0.004876055754721165,
0.005001464392989874,
-0.018389087170362473,
-0.03902026638388634,
0.0030788290314376354,
-0.0058698286302387714,
0.006585209630429745,
-0.029319869354367256,
-0.016831282526254654,
-0.007432836107909679,
-0.01831265538930893,
-0.015408294275403023,
-0.028082838281989098,
0.00558789586648345,
0.004473230801522732,
-0.00010534003376960754,
-0.011681318283081055,
-0.008244475349783897,
0.007187936455011368,
0.022386744618415833,
0.020688625052571297,
-0.019520893692970276,
-0.001902048708871007,
0.010391653515398502,
0.0008843513205647469,
-0.021709391847252846,
-0.006795711349695921,
-0.0018029941711574793,
-0.012617465108633041,
-0.005037704017013311,
0.008098240941762924,
0.005261262878775597,
-0.002294879872351885,
0.0006524847121909261,
-0.012436753138899803,
-0.01023018080741167,
0.013217946514487267,
-0.008133220486342907,
0.007025498431175947,
0.0002914255019277334,
-0.018459375947713852,
-0.01348869502544403,
0.01277507096529007,
0.017676863819360733,
0.006506771314889193,
0.013390205800533295,
-0.0096014104783535,
0.012893511913716793,
-0.005975321866571903,
-0.00785745121538639,
-0.007796289399266243,
0.03611624985933304,
-0.02653580904006958,
0.02416035160422325,
0.004489244893193245,
0.019829342141747475,
-0.0032548648305237293,
0.006609584204852581,
-0.010068114846944809,
0.010451432317495346,
0.0035706129856407642,
-0.00868901051580906,
-0.0015563881024718285,
-0.016410991549491882,
-0.023369580507278442,
0.0171644426882267,
-0.011923796497285366,
0.027149349451065063,
-0.0025302646681666374,
-0.002088573994114995,
0.005407867953181267,
-0.00576805230230093,
0.0012837368994951248,
0.003199542872607708,
-0.014291821978986263,
-0.008933989331126213,
0.03157408535480499,
-0.004197513684630394,
0.013286584988236427,
0.005828362423926592,
0.00025024876231327653,
0.01223965547978878,
-0.08122484385967255,
-0.022704346105456352,
-0.00797591544687748,
0.002311131451278925,
0.007717914413660765,
-0.028169890865683556,
-0.018111232668161392,
-0.005605360027402639,
0.0060897027142345905,
-0.008204727433621883,
-0.02631775476038456,
0.013669919222593307,
-0.011998183093965054,
-0.01222275197505951,
0.0033514834940433502,
-0.008610108867287636,
0.014327839016914368,
-0.03968517854809761,
0.01652667298913002,
-0.0067749954760074615,
0.022045772522687912,
-0.016735533252358437,
-0.0035217744298279285,
0.011325865052640438,
-0.020789258182048798,
0.020061712712049484,
0.03232385963201523,
-0.001855385722592473,
-0.0006263458635658026,
0.00966902170330286,
-0.029868725687265396,
-0.019661499187350273,
0.013850340619683266,
0.006145467981696129,
0.027291934937238693,
-0.0066428701393306255,
0.013154166750609875,
0.010392449796199799,
-0.019714737311005592,
0.04741331562399864,
0.0027865052688866854,
0.023658107966184616,
0.0028929905965924263,
0.015217328444123268,
0.02895473688840866,
0.0013529974967241287,
0.024530278518795967,
-0.006155397742986679,
0.013088623061776161,
-0.007556214928627014,
-0.03786108270287514,
0.002482641488313675,
-0.019346455112099648,
0.021522726863622665,
-0.00035112572368234396,
-0.03197624906897545,
-0.021686209365725517,
0.017159175127744675,
-0.015953432768583298,
-0.016825713217258453,
0.019065089523792267,
-0.0433223620057106,
0.021444100886583328,
0.06266651302576065,
0.027184683829545975,
0.017914967611432076,
0.012798341922461987,
0.005846137180924416,
-0.0086584547534585,
0.0111274104565382,
-0.016860945150256157,
-0.021324731409549713,
-0.012713195756077766,
-0.011728215962648392,
-0.036792512983083725,
-0.014278482645750046,
-0.007557759992778301,
0.00888401921838522,
-0.006623406894505024,
-0.02564985677599907,
-0.012962219305336475,
0.013965638354420662,
-0.02759683132171631,
-0.018642183393239975,
-0.013213164173066616,
-0.013071142137050629,
0.00938507728278637,
0.05196372792124748,
0.010209071449935436,
-0.015527076087892056,
0.008895965293049812,
-0.014731647446751595,
-0.032289281487464905,
0.004742802586406469,
-0.02538212016224861,
-0.013894684612751007,
0.0009777350351214409,
-0.0036120712757110596,
0.003974354825913906,
0.008362051099538803,
-0.023807484656572342,
0.00033314432948827744,
0.0067465826869010925,
-0.011060679331421852,
-0.003025602549314499,
0.01406797394156456,
0.013669559732079506,
0.002979697659611702,
0.00508536072447896,
0.00348892854526639,
-0.005799526814371347,
-0.009345603175461292,
-0.008190426975488663,
0.010852770879864693,
0.007064261473715305,
0.012882675975561142,
0.0011845140252262354,
-0.012690313160419464,
0.0716196596622467,
-0.021605338901281357,
-0.01091730035841465,
-0.00872020423412323,
0.010274934582412243,
-0.019879557192325592,
-0.029901282861828804,
0.004606102127581835,
-0.05007445812225342,
-0.003894902765750885,
0.014907068572938442,
-0.01313997432589531,
-0.01699736714363098,
-0.020833127200603485,
-0.00006694160401821136,
-0.013108987361192703,
0.001691116951406002,
0.018008599057793617,
0.023695454001426697,
-0.01161915436387062,
0.022258039563894272,
0.006415202282369137,
-0.015068808570504189,
-0.020144537091255188,
0.008064834401011467,
-0.02689453959465027,
0.018293019384145737,
-0.010771838016808033,
-0.02122342959046364,
0.01301867701113224,
-0.027052000164985657,
-0.020595740526914597,
-0.007842330262064934,
-0.014330803416669369,
0.013614075258374214,
0.026530403643846512,
0.010479140095412731,
-0.01839248463511467,
0.006894088815897703,
0.0012468849308788776,
-0.02124876156449318,
-0.008105505257844925,
-0.015146525576710701,
0.01060631312429905,
-0.013756864704191685,
0.004376033321022987,
0.0150812529027462,
-0.007019895128905773,
0.0020684446208178997,
-0.02782253362238407,
-0.016699019819498062,
0.02215006947517395,
0.014183368533849716,
-0.003452472621574998,
-0.01253750640898943,
0.01911254972219467,
-0.002243603114038706,
-0.013560519553720951,
-0.0131487175822258,
0.009845918975770473,
-0.010944396257400513,
0.024270307272672653,
-0.007650291081517935,
-0.01591147854924202,
0.00904887355864048,
-0.010511047206819057,
-0.0009965281933546066,
0.007558672223240137,
-0.017032114788889885,
-0.026334555819630623,
0.014606541022658348,
-0.010042923502624035,
0.00011016428470611572,
0.020965851843357086,
-0.013392013497650623,
0.024791855365037918,
-0.0008590277284383774,
0.0060805873945355415,
0.025749271735548973,
0.020117709413170815,
-0.039776042103767395,
0.0006828350014984608,
0.007547276094555855,
-0.011162483133375645,
0.00487483898177743,
0.022834407165646553,
0.008449518121778965,
-0.0745784267783165,
-0.015038065612316132,
-0.021917786449193954,
-0.003546658670529723,
0.0029739183373749256,
-0.014513086527585983,
-0.016317881643772125,
0.021452421322464943,
0.022946057841181755,
-0.009450814686715603,
-0.025321897119283676,
0.00017966562882065773,
-0.008448857814073563,
0.009756147861480713,
0.012417111545801163,
0.011547635309398174,
-0.004720074124634266,
-0.007296983618289232,
-0.025285795331001282,
-0.013822123408317566,
0.012482586316764355,
-0.013696491718292236,
-0.0447729155421257,
0.02241295948624611,
0.016187014058232307,
-0.08052274584770203,
-0.018651317805051804,
-0.016100212931632996,
-0.030236493796110153,
0.02248486876487732,
0.0007045797538012266,
-0.0245707668364048,
-0.019364923238754272,
0.0033030258491635323,
-0.014479195699095726,
0.023452110588550568,
0.006500317715108395,
-0.0486803837120533,
-0.03198094293475151,
0.007247202564030886,
-0.010020848363637924,
0.00048765866085886955,
-0.025873759761452675,
0.005942628253251314,
-0.02278916910290718,
0.006665785331279039,
0.009711045771837234,
-0.011274965479969978,
0.021405253559350967,
-0.0006220374489203095,
0.011182775720953941,
0.007439418695867062,
0.01141248270869255,
-0.00023802765645086765,
0.004550897516310215,
-0.0032487744465470314,
-0.005025127902626991,
-0.008597910404205322,
-0.044512685388326645,
-0.009778869338333607,
-0.020791810005903244,
0.02745380997657776,
0.00646875100210309,
0.010725041851401329,
-0.012217780575156212,
-0.009625878185033798,
-0.010268696583807468,
-0.030818866565823555,
-0.010138468816876411,
0.0307928454130888,
-0.003430366050451994,
0.006344154942780733,
-0.0034729205071926117,
0.013189907185733318,
0.006369617767632008,
0.0029450873844325542,
-0.012748641893267632,
0.007437302730977535,
-0.004144532606005669,
-0.0018871859647333622,
0.023188132792711258,
0.003641065675765276,
0.00008396652992814779,
-0.014073236845433712,
0.0048158783465623856,
-0.005883336067199707,
0.009382829070091248,
0.007017982192337513,
0.07150231301784515,
-0.024019848555326462,
0.026671530678868294,
-0.0287904255092144,
0.010263597592711449,
0.0061401501297950745,
-0.00465429900214076,
-0.018504086881875992,
-0.030830170959234238,
-0.03490034118294716,
0.01814090833067894,
-0.00966675579547882,
-0.020859763026237488,
0.01280936598777771,
-0.0027463743463158607,
-0.006142527796328068,
0.021916188299655914,
0.013116300106048584,
-0.025513246655464172,
0.036297716200351715,
0.017059016972780228,
-0.00827346183359623,
-0.039677731692790985,
0.006775165908038616,
0.004795830696821213,
-0.006678321864455938,
-0.008704161271452904,
-0.005795211531221867,
-0.029902100563049316,
-0.016085714101791382,
-0.005146881565451622,
0.0017454582266509533,
0.00014957378152757883,
-0.005461111199110746,
0.0182228684425354,
0.02292167767882347,
-0.007065198849886656,
0.0067874593660235405,
-0.011218625120818615,
0.008344114758074284,
-0.0012725985143333673,
-0.0022261966951191425,
-0.008218364790081978,
0.003841504454612732,
-0.005550559144467115,
0.04736541211605072,
0.010455909185111523,
-0.0305585078895092,
-0.003748578717932105,
-0.004902055952697992,
-0.0194326750934124,
0.004643640015274286,
0.02156168594956398,
-0.02624889463186264,
0.004668567329645157,
0.01513561699539423,
0.02645193040370941,
0.01531272567808628,
-0.008927542716264725,
-0.005258880089968443,
-0.005119239911437035,
-0.012376416474580765,
0.0016346732154488564,
-0.009766471572220325,
0.018149644136428833,
0.025303691625595093,
0.028012163937091827,
-0.017033150419592857,
-0.02296852320432663,
0.013436706736683846,
-0.01818433217704296,
-0.024591702967882156,
0.00709559815004468,
0.013271786272525787,
0.008849307894706726,
0.002184310695156455,
-0.0013641263358294964,
-0.00964457169175148,
-0.00442580645903945,
0.01954672858119011,
-0.0063268644735217094,
0.01266380213201046,
0.02698562480509281,
0.015037616714835167,
-0.011608571745455265,
-0.01936301589012146,
-0.022687027230858803,
0.005719807464629412,
0.0015474077081307769,
0.018329735845327377,
0.014457490295171738,
-0.006163152866065502,
0.0029137292876839638,
0.01411404088139534,
0.008846264332532883,
0.03556480631232262,
0.01908610202372074,
0.0010247031459584832,
0.006737095769494772,
0.014677257277071476,
0.016101427376270294,
-0.0028792722150683403,
0.007210710551589727,
0.012661322951316833,
0.01710464060306549,
-0.0024004080332815647,
-0.009280607104301453,
0.021716486662626266,
0.01804228127002716,
0.014799199067056179,
0.008092292584478855,
0.00235738605260849,
-0.008427267894148827,
0.009550705552101135,
0.0017188368365168571,
0.021408211439847946,
-0.020756348967552185,
-0.006139949429780245,
-0.044042766094207764,
-0.013901851139962673,
0.008829384110867977,
-0.0025789602659642696,
-0.009206061251461506,
0.01950887218117714,
-0.010794052854180336,
-0.004614356439560652,
-0.006928745191544294,
-0.006274214014410973,
0.010948154143989086,
0.0051697660237550735,
0.002447130624204874,
-0.005980893969535828,
0.01870143413543701,
0.006642127875238657,
0.003190605202689767,
0.018844813108444214,
-0.016363009810447693,
0.015151672065258026,
0.007233697921037674,
0.01720546744763851,
0.015963267534971237,
-0.02278740331530571,
-0.004659237340092659,
0.0029544727876782417,
0.007809119764715433,
-0.025271974503993988,
0.01320604793727398,
-0.008280415087938309,
0.015422940254211426,
0.009188894182443619,
0.010448519140481949,
0.0009019483113661408,
-0.00022819009609520435,
-0.01206299103796482,
0.005428411066532135,
0.029752645641565323,
0.03284967690706253,
-0.011135212145745754,
-0.028705894947052002,
-0.011411134153604507,
-0.006948321126401424,
-0.03137960284948349,
-0.03035975992679596,
-0.012692729011178017,
0.019477441906929016,
0.010809740982949734,
-0.021738912910223007,
0.004878922365605831,
0.02580694854259491,
0.013904161751270294,
0.019974062219262123,
-0.0003442009910941124,
-0.007848452776670456,
0.026022514328360558,
-0.012224053964018822,
-0.001662243390455842,
0.010772231966257095,
0.004613632336258888,
0.003909526392817497,
-0.0005866130813956261,
0.003729697549715638,
-0.007764399982988834,
0.002617967315018177,
-0.002123575657606125,
0.0034559110645204782,
-0.015375765040516853,
0.0008056891383603215,
-0.01172941830009222,
-0.008306724950671196,
-0.007026641629636288,
0.0015716757625341415,
-0.011096448637545109,
-0.011968527920544147,
0.0167744942009449,
-0.0035862564109265804,
0.0011411430314183235,
0.04278019815683365,
-0.043363407254219055,
0.01398099772632122,
-0.0031242005061358213,
-0.019489802420139313,
-0.02000056952238083
] | [
0.4019050598144531,
-0.11717986315488815,
0.5297544598579407,
0.11833324283361435,
0.07924593240022659,
0.2254798859357834,
0.25730690360069275,
0.020247580483555794,
-0.3604048788547516,
-0.7066942453384399,
0.2361743152141571,
0.2632441520690918,
-0.3363211750984192,
-0.16389606893062592,
0.4143003225326538,
0.2875578701496124,
0.42555147409439087,
0.6874061226844788,
-0.08923500031232834,
-0.47054973244667053,
-0.17631663382053375,
0.1414678990840912,
0.36269086599349976,
0.13002747297286987,
0.18661381304264069,
-0.05061350762844086,
0.06141487509012222,
-0.1658352166414261,
0.209876149892807,
-0.11585007607936859,
0.2302524596452713,
0.6060692071914673,
-0.15485472977161407,
-0.12614940106868744,
-0.14745409786701202,
-0.1728636771440506,
-0.3139474391937256,
-0.1211218535900116,
0.12064334750175476,
-0.11799214780330658,
-0.30013737082481384,
-0.13025298714637756,
-0.2249097377061844,
0.3494671881198883,
-0.19129732251167297,
-0.2177778035402298,
-1.5553288459777832,
0.47157755494117737,
0.1598677635192871,
0.126234769821167,
-0.2630044221878052,
0.06273409724235535,
-0.2171071618795395,
0.40626105666160583,
0.1943647712469101,
0.1672326773405075,
-0.8966873288154602,
0.10408987104892731,
0.5030080676078796,
-0.5197263956069946,
0.36706557869911194,
-0.26304885745048523,
-0.3947412669658661,
0.2321595847606659,
-0.10989053547382355,
0.5915606617927551,
0.0945444330573082,
-0.38771048188209534,
-0.5024544596672058,
-0.22334891557693481,
0.32385846972465515,
-0.5824914574623108,
-0.057013608515262604,
0.0021143623162060976,
-0.02453707903623581,
-0.23894858360290527,
-0.4534648358821869,
-0.1635018140077591,
0.2164832353591919,
0.4286910891532898,
-0.26510730385780334,
0.18164972960948944,
0.4021241068840027,
0.12407699972391129,
0.5301185846328735,
0.3468906581401825,
-0.08152060955762863,
0.5147483944892883,
-0.38345903158187866,
-0.21762356162071228,
-0.0717063695192337,
-0.16666172444820404,
0.6411341428756714,
-0.1510467827320099,
0.1730053424835205,
0.5096879005432129,
0.3859037160873413,
-0.028734317049384117,
0.053930219262838364,
0.11362110823392868,
-0.4442020654678345,
0.10686700791120529,
-0.31772851943969727,
-0.10956238955259323,
-0.9102768301963806,
-0.0341133289039135,
-0.1734311878681183,
-0.32711538672447205,
-0.1798969954252243,
0.2800890803337097,
-0.5235320329666138,
-0.5963869094848633,
-0.527887761592865,
-0.19678238034248352,
-0.039133016020059586,
-0.2041759490966797,
0.08039786666631699,
-0.44524964690208435,
-0.07882462441921234,
0.4075736403465271,
0.13937018811702728,
1.0261504650115967,
0.09131389111280441,
0.36645621061325073,
-0.1400860697031021,
-0.26043733954429626,
0.3553672730922699,
-0.11010223627090454,
0.06950696557760239,
0.4882599711418152,
0.21124690771102905,
0.8984633088111877,
-0.36498165130615234,
0.1979644000530243,
0.16016921401023865,
-0.14163488149642944,
0.12614044547080994,
0.491024911403656,
0.20886915922164917,
0.0790136530995369,
-0.6731563806533813,
-0.4954001307487488,
0.028157534077763557,
-0.07438704371452332,
-0.20937411487102509,
-0.5534932613372803,
-0.6351020336151123,
0.008734229952096939,
0.3650142550468445,
-0.5980917811393738,
-0.16323640942573547,
-0.27082914113998413,
-0.19690333306789398,
-0.14208807051181793,
-0.005466572009027004,
0.22824726998806,
0.15015453100204468,
0.23284710943698883,
0.32354384660720825,
0.2086281180381775,
-0.1717446893453598,
0.22172528505325317,
0.10655272006988525,
-0.046722277998924255,
0.1986294984817505,
0.211762472987175,
0.4599703550338745,
0.5810038447380066,
0.28828948736190796,
-0.08304256945848465,
-0.33502259850502014,
-0.2069060206413269,
0.1338636875152588,
-0.47763505578041077,
-0.029879510402679443,
-0.02563917264342308,
0.5399618744850159,
0.14045396447181702,
-0.13001076877117157,
-0.31871551275253296,
-0.7183323502540588,
0.2760580778121948,
-0.4899294674396515,
-0.6366695165634155,
0.3316490948200226,
-0.029421541839838028,
0.14756037294864655,
-0.20223262906074524,
-0.06575588136911392,
0.1664564311504364,
0.23749816417694092,
-0.031418509781360626,
0.7046149969100952,
-0.6773380041122437,
1.1895250082015991,
-0.4371984004974365,
-0.2493620663881302,
0.9534921646118164,
0.06849315017461777,
-0.3029678761959076,
-0.23306365311145782,
-0.3274558186531067,
0.5383190512657166,
-0.5081611275672913,
-0.5671943426132202,
0.39656952023506165,
0.07455900311470032,
-0.25581902265548706,
0.2786242365837097,
-0.22483649849891663,
0.2083452194929123,
-0.13536295294761658,
-0.04164687916636467,
-0.33964794874191284,
0.26177871227264404,
-0.43272870779037476,
-0.5827540755271912,
-0.1494663804769516,
-0.4812367558479309,
-0.039392370730638504,
0.4104546308517456,
-0.503970742225647,
0.4710841774940491,
1.1169737577438354,
-0.0699593722820282,
0.342094749212265,
0.5773724913597107,
-0.00888670701533556,
1.021369218826294,
-0.06242448091506958,
0.14623504877090454,
-0.7731536030769348,
-0.0740630030632019,
-0.5526241064071655,
-0.5471431612968445,
0.3754391670227051,
0.2962827980518341,
-0.27451881766319275,
0.02978062815964222,
-0.007971376180648804,
-0.04762417450547218,
0.46864989399909973,
-0.7956527471542358,
-0.0739326998591423,
-0.004368164110928774,
-0.17821809649467468,
-0.42768600583076477,
0.017795683816075325,
-0.7905237674713135,
-0.01601225696504116,
-0.1524440199136734,
0.35364294052124023,
-0.12893804907798767,
-0.4368448257446289,
0.7484322190284729,
-0.2194175124168396,
-0.07134183496236801,
0.30521199107170105,
0.2748490273952484,
-0.40673232078552246,
-0.14114829897880554,
-0.20249056816101074,
-0.049758296459913254,
0.6446557641029358,
0.010737447999417782,
-0.46658819913864136,
-0.7444541454315186,
-0.2415865957736969,
1.1465108394622803,
0.8494841456413269,
0.9400851130485535,
-0.009191647171974182,
-0.3883204460144043,
-0.05552605539560318,
0.034858256578445435,
-0.28643304109573364,
0.08355746418237686,
0.7465457916259766,
-0.10122112184762955,
-0.21080894768238068,
-0.1797928363084793,
0.008559098467230797,
0.6714946627616882,
-0.20637428760528564,
-0.0762336403131485,
-0.19816599786281586,
-0.1877865195274353,
-0.13648861646652222,
-0.24665285646915436,
-0.4010992646217346,
-0.1793728470802307,
-0.03699088841676712,
-0.06292877346277237,
-0.10572576522827148,
0.22034113109111786,
0.16258582472801208,
-0.19038377702236176,
0.43462657928466797,
0.4279061257839203,
-0.34601274132728577,
-0.1227983683347702,
0.11593092232942581,
0.03370887413620949,
0.08322722464799881,
-0.04304026812314987,
-0.1198650524020195,
-0.44096827507019043,
0.5168780088424683,
-5.994558334350586,
0.2751735746860504,
-0.012721960432827473,
0.01886804588139057,
0.1538160741329193,
-0.27170127630233765,
0.8708555102348328,
0.19822140038013458,
0.43770113587379456,
0.038680706173181534,
0.5060138702392578,
0.6232850551605225,
-0.1784650832414627,
0.11801214516162872,
-0.41481995582580566,
-0.020452391356229782,
0.020746268332004547,
-0.07511033862829208,
0.5152697563171387,
-0.16556251049041748,
-0.11803331226110458,
-0.2736479640007019,
0.0912047028541565,
0.6786890625953674,
-0.06262301653623581,
0.0021308008581399918,
-0.6384665966033936,
-0.04881332069635391,
0.04383375495672226,
0.11921483278274536,
-0.5845702886581421,
-0.5807031393051147,
0.17977634072303772,
-0.2505137622356415,
0.44737228751182556,
-0.2126045525074005,
0.0000835480386740528,
0.012197103351354599,
-0.2016194462776184,
-0.5166850090026855,
0.2421419322490692,
0.45285460352897644,
-0.4586541950702667,
-0.5229138135910034,
0.01637941040098667,
-0.09592240303754807,
-0.409408837556839,
0.4107116162776947,
-0.21663083136081696,
0.7075143456459045,
-0.11558322608470917,
-0.37182724475860596,
0.3035261332988739,
0.5357027649879456,
0.7819132208824158,
-0.1467914581298828,
-0.07666081190109253,
-0.3667251467704773,
-0.4358237087726593,
0.30906930565834045,
-0.5818191170692444,
-0.06305941194295883,
-0.3803514242172241,
-0.14866198599338531,
0.31572017073631287,
0.3568255305290222,
-0.9154853224754333,
-0.5314662456512451,
0.24959434568881989,
-0.33913150429725647,
-0.41535040736198425,
0.10235609114170074,
0.11630941927433014,
-0.6808184385299683,
0.5452637076377869,
-0.326135516166687,
0.14956770837306976,
0.04608061537146568,
0.29200759530067444,
-0.1326756477355957,
-0.30211952328681946,
-0.0015313662588596344,
-0.1404908001422882,
-0.27053990960121155,
-0.1171262115240097,
-0.29437223076820374,
-0.10260695219039917,
0.011043809354305267,
-0.26371660828590393,
0.1297435313463211,
0.4321112632751465,
-0.19068436324596405,
0.2745693325996399,
0.6589605808258057,
-0.03366611897945404,
0.37510839104652405,
0.4135623574256897,
0.3427972197532654,
0.12574094533920288,
-0.4428750276565552,
1.2915352582931519,
-0.009028300642967224,
-0.5015811920166016,
-0.8305534720420837,
-0.04849648475646973,
0.3256200850009918,
-0.6799581050872803,
0.41550809144973755,
0.557890772819519,
-0.6293066143989563,
-0.3938690423965454,
-0.02479022927582264,
-0.6116295456886292,
-0.39684489369392395,
0.8581042289733887,
-0.3887180685997009,
-0.3454819321632385,
0.33110150694847107,
0.946236789226532,
-0.4485131502151489,
0.40998515486717224,
0.5938962697982788,
-0.3700409233570099,
0.07445108145475388,
0.10007774829864502,
0.35433200001716614,
0.08723682910203934,
0.5603999495506287,
-0.7458193898200989,
-0.15868857502937317,
0.2072252631187439,
0.1665174812078476,
-0.14939777553081512,
0.5413293838500977,
0.3011208772659302,
-0.4843381345272064,
-0.3193165361881256,
0.2848780155181885,
0.10668965429067612,
-0.3272448778152466,
0.4257239103317261,
-0.15266311168670654,
-0.22872768342494965,
0.2944200336933136,
0.17007333040237427,
0.35976430773735046,
-0.3383713364601135,
-0.028047557920217514,
-0.26251861453056335,
0.043698955327272415,
0.44091132283210754,
-0.1762704998254776,
0.15165415406227112,
0.09955189377069473,
0.004788752645254135,
0.3260796070098877,
0.5261130928993225,
0.12693889439105988,
0.39406391978263855,
-0.5796207785606384,
0.1906006634235382,
0.4240547716617584,
-0.8344471454620361,
0.272042840719223,
-0.2757994830608368,
-0.3446016311645508,
-0.13150252401828766,
-0.5551154017448425,
-0.21443603932857513,
0.10767956078052521,
-0.2606313228607178,
0.029071496799588203,
-0.3525189757347107,
0.08096009492874146,
0.026120319962501526,
-0.4550124406814575,
-0.35731959342956543,
0.5325294733047485,
-0.30742356181144714,
-0.21714997291564941,
0.29107213020324707,
-0.3343789875507355,
-0.24314191937446594,
0.13789772987365723,
0.5009226202964783,
-0.1555519551038742,
0.3812321126461029,
-0.32009002566337585,
-0.168132945895195,
-0.19447043538093567,
0.744415819644928,
0.47363319993019104,
-0.38389676809310913,
-0.3015107810497284,
0.34060999751091003,
0.11884847283363342,
-0.06766799837350845,
0.7477337121963501,
-0.19486936926841736,
-0.18721580505371094,
0.5293601751327515,
0.21056008338928223,
-0.5425753593444824,
0.5328143239021301,
0.09359655529260635,
0.21531495451927185,
0.03127950429916382,
0.28687891364097595,
-0.15994085371494293,
0.0011725742369890213,
-0.3498983085155487,
-0.11778905242681503,
0.44147560000419617,
0.6460868120193481,
-0.07041407376527786,
-0.22591255605220795,
-0.15440404415130615,
-0.30793243646621704,
-0.036513276398181915,
0.4016496241092682,
0.12118933349847794,
0.04796040058135986,
-0.24264460802078247,
-0.14340601861476898,
0.0007075810572132468,
0.34716343879699707,
0.5415229797363281,
-0.6568398475646973,
-0.06692606955766678,
0.4892561435699463,
-0.03851665183901787,
-0.2741427421569824,
0.03220001980662346,
-0.10423990339040756,
-0.1476704627275467,
-0.4376649558544159,
-0.12126202881336212,
0.06475826352834702,
-0.1735435128211975,
0.11643907427787781,
0.140112966299057,
0.18801534175872803,
-0.6664302349090576,
-0.31624001264572144,
0.36130818724632263,
0.8074302077293396,
0.16234464943408966,
-0.6668018698692322,
-0.4591933488845825,
-0.16013744473457336,
0.3722867965698242,
0.006021834909915924,
0.4735981523990631,
0.3016374409198761,
0.7673221230506897,
-0.03353344276547432,
-0.04174652695655823,
0.000708885258063674,
0.28842705488204956,
0.05952154099941254,
-0.12338289618492126,
-0.3547056317329407,
-0.0978303849697113,
0.10431870818138123,
0.15310759842395782,
-0.11598869413137436,
-0.17533962428569794,
-0.51798015832901,
0.3066709637641907,
-0.0022771330550312996,
0.10117406398057938,
-0.21754741668701172,
0.7388052940368652,
0.3785881996154785,
-0.1316937953233719,
0.226749449968338,
-0.4613790512084961,
0.09062887728214264,
-0.47363755106925964,
0.2094864547252655,
-0.35484787821769714,
-0.9452749490737915,
-0.01690669171512127,
-0.055201705545186996,
0.6692076325416565,
-0.6599556803703308,
0.07551944255828857,
-0.2776871621608734,
0.23221012949943542,
-0.0672522783279419,
-0.4579469561576843,
-0.231768399477005,
-0.5102609992027283,
-0.3723847568035126,
0.30258607864379883,
0.5965423583984375,
-0.03240739181637764,
0.3616427779197693,
-0.19775575399398804,
0.15554408729076385,
-0.6197305917739868,
0.40989938378334045,
0.24204495549201965,
-0.32232293486595154,
-0.04611904174089432,
0.5206790566444397,
0.22560608386993408,
-0.12269098311662674,
-0.8091216087341309,
0.06252331286668777,
-0.03566440939903259,
-0.20357203483581543,
0.27441835403442383,
0.026717988774180412,
-0.31694820523262024,
-0.06009313091635704,
0.08409536629915237,
-0.32812291383743286,
0.055835794657468796,
0.24039587378501892,
0.4326501488685608,
0.650201678276062,
0.35483428835868835,
0.013925883919000626,
-0.31704482436180115,
0.584604799747467,
0.19781340658664703,
0.19367024302482605,
0.05644616112112999,
0.3595542311668396,
1.1533488035202026,
0.37925538420677185,
-0.4399872422218323,
0.27226385474205017,
0.5154324173927307,
0.27011924982070923,
-0.0694834515452385,
-0.42079609632492065,
-0.4386717975139618,
0.2051665484905243,
0.7064043879508972,
0.2833254635334015,
-0.04881228879094124,
-0.2415604442358017,
-0.012779719196259975,
0.3161581754684448,
-0.016557637602090836,
0.18616832792758942,
-0.2650637626647949,
0.07929237931966782,
0.231772780418396,
-0.6008682250976562,
-0.429685115814209,
0.20822761952877045,
-0.655574381351471,
0.09343045204877853,
0.33043262362480164,
-0.29476818442344666,
-0.2683175206184387,
-0.10033431649208069,
-0.4556930363178253,
-0.02067415602505207,
0.08486811816692352,
0.2476438283920288,
-0.000032525113056181,
-0.016111835837364197,
0.6574093699455261,
-0.573409378528595,
0.32305455207824707,
-0.12763527035713196,
-0.19200581312179565,
0.005566352512687445,
0.023706357926130295,
0.06252247095108032,
0.1927385926246643,
-0.5565535426139832,
-0.27201592922210693,
-0.009461191482841969,
-0.20318439602851868,
0.5340898036956787,
-0.05366213247179985,
0.25225597620010376,
-0.12576235830783844,
-0.7546266913414001,
-0.300682932138443,
0.10311061888933182,
-0.4616954028606415,
-0.5762373805046082,
-0.18699835240840912,
0.09074229747056961,
-0.05607467517256737,
-0.5575857162475586,
0.26899445056915283,
0.01877327635884285,
0.4455852806568146,
0.3145264685153961,
0.05384129658341408,
0.288393497467041,
0.481521874666214,
0.17047001421451569,
0.07584378123283386,
0.6763748526573181,
-0.04661369323730469,
0.08947134763002396,
-0.7470771670341492,
0.3538146913051605,
-0.4624923765659332,
-0.5156426429748535,
-0.6128209829330444,
-0.23015257716178894,
1.1109281778335571,
0.4434092938899994,
-0.398194819688797,
0.032842542976140976,
0.5695679187774658,
0.5083681344985962,
0.40733572840690613,
-0.420852392911911,
-0.2607744634151459,
-0.594828724861145,
-0.2088397890329361,
-0.5246689319610596,
0.6246430277824402,
0.1206107810139656,
-0.05553974211215973,
-0.20636707544326782,
0.19025486707687378,
-0.03352376073598862,
-0.3548416197299957,
0.27061527967453003,
-0.3633381128311157,
0.006718997843563557,
-0.7217777371406555,
0.08722888678312302,
-0.40650269389152527,
-0.0644511729478836,
-0.4482293426990509,
-0.3166170120239258,
0.6093820929527283,
-0.3236315846443176,
0.5948792099952698,
0.0068130032159388065,
0.18484605848789215,
0.15373431146144867,
0.04517153650522232,
-0.07917113602161407,
-0.1727752387523651,
-0.735429048538208,
-0.3171880841255188,
0.188210591673851,
0.2898993492126465,
-0.5351366996765137,
0.14689797163009644,
0.05712831765413284,
0.18066680431365967,
0.3052257001399994,
0.25622254610061646,
-0.24337221682071686,
-0.4201287627220154,
0.3276224136352539
] |
Here, we report that genome editing by CRISPR–Cas9 induces a p53-mediated DNA damage response and cell cycle arrest in immortalized human retinal pigment epithelial cells, leading to a selection against cells with a functional p53 pathway. Inhibition of p53 prevents the damage response and increases the rate of homologous recombination from a donor template. These results suggest that p53 inhibition may improve the efficiency of genome editing of untransformed cells and that p53 function should be monitored when developing cell-based therapies utilizing CRISPR–Cas9. CRISPR–Cas9-induced DNA damage triggers p53 to limit the efficiency of gene editing in immortalized human retinal pigment epithelial cells. | [
0.001685373019427061,
0.0012551727704703808,
-0.009915880858898163,
0.02301972731947899,
0.020176324993371964,
-0.02083730325102806,
0.011556018143892288,
0.00451473705470562,
-0.01203251164406538,
-0.0016790442168712616,
-0.010837487876415253,
0.007503952831029892,
-0.01490105502307415,
0.018784435465931892,
-0.013624985702335835,
0.019260765984654427,
-0.010994071140885353,
0.016625534743070602,
0.014022430405020714,
-0.01662854105234146,
0.017438095062971115,
-0.01612181030213833,
0.011657482013106346,
-0.023137781769037247,
0.0005372259765863419,
0.02217109501361847,
0.026444923132658005,
-0.020985197275877,
-0.00939268060028553,
-0.04012449085712433,
0.04620477557182312,
-0.009132275357842445,
0.01324393879622221,
0.003522333921864629,
0.0010542443487793207,
-0.00005507888272404671,
-0.00299334479495883,
0.020106427371501923,
0.05538145452737808,
-0.005240264814347029,
-0.0059674521908164024,
-0.012320354580879211,
0.006425270810723305,
-0.0012307416182011366,
-0.009422450326383114,
-0.015821548178792,
-0.0014955252408981323,
0.006216689478605986,
0.016416333615779877,
0.007020674180239439,
-0.010669082403182983,
-0.044107191264629364,
-0.007288035936653614,
-0.008365651592612267,
-0.007304634898900986,
0.0006676246412098408,
0.02086435630917549,
0.004451077897101641,
-0.0035739955492317677,
-0.018425939604640007,
-0.0011680983006954193,
-0.037757668644189835,
0.02219947800040245,
-0.004752923734486103,
-0.022260883823037148,
-0.06662505865097046,
0.004666584078222513,
-0.004412862937897444,
0.01855887845158577,
-0.009387522004544735,
0.0009313679183833301,
0.010878784582018852,
-0.013811800628900528,
0.024229606613516808,
-0.00388671038672328,
-0.02763178199529648,
-0.009473244659602642,
0.008157839998602867,
0.021164868026971817,
-0.0002741655334830284,
-0.024227002635598183,
-0.014455268159508705,
0.03166578710079193,
0.03512834385037422,
-0.013000188395380974,
0.016101447865366936,
-0.017937496304512024,
-0.014473849907517433,
-0.0009529000381007791,
-0.017292674630880356,
0.008524559438228607,
0.0009488370269536972,
-0.0024698697961866856,
-0.010730934329330921,
-0.03701455146074295,
0.03628009557723999,
-0.01763327792286873,
0.011755948886275291,
0.01849117875099182,
-0.016155818477272987,
-0.014526770450174809,
0.016241393983364105,
0.015413185581564903,
0.004568504169583321,
-0.003617092501372099,
0.005579247139394283,
0.019062280654907227,
0.014654245227575302,
0.03407762944698334,
0.009417304769158363,
0.00981734786182642,
0.005489202681928873,
-0.004954342730343342,
0.03396705165505409,
0.00098140025511384,
0.0011180266737937927,
-0.014566861093044281,
0.01825883239507675,
0.01161415595561266,
0.026557154953479767,
0.009718738496303558,
0.006177026778459549,
0.000601890089455992,
0.010703116655349731,
0.00261059682816267,
0.006844814401119947,
0.02144136279821396,
-0.005201549734920263,
-0.006253782659769058,
0.009598945267498493,
-0.011386234313249588,
0.012466274201869965,
-0.0072441622614860535,
-0.004460887052118778,
0.007698005996644497,
0.006397516932338476,
-0.022501502186059952,
-0.018646089360117912,
-0.0037809221539646387,
0.008202181197702885,
0.0008331192657351494,
0.012597091495990753,
-0.0033756957855075598,
0.02137909084558487,
-0.002244234085083008,
0.02329370379447937,
-0.006957011763006449,
-0.010505435056984425,
-0.008862761780619621,
-0.03701099008321762,
-0.002448658924549818,
0.016430586576461792,
-0.03130347281694412,
-0.01063711941242218,
-0.00723356194794178,
0.0006426903419196606,
-0.034787848591804504,
-0.012288728728890419,
-0.006021223962306976,
0.01175581943243742,
-0.011415880173444748,
-0.015442531555891037,
0.007672691717743874,
0.009173821657896042,
0.021010881289839745,
-0.03633376955986023,
-0.017678620293736458,
-0.01675940491259098,
-0.0036546962801367044,
0.0077667259611189365,
-0.010973838157951832,
0.046567387878894806,
0.015234659425914288,
0.005969585385173559,
0.007066968362778425,
-0.014876480214297771,
0.02362271398305893,
0.0075121414847671986,
-0.0017248078947886825,
0.06644365191459656,
-0.01659204438328743,
-0.008893106132745743,
0.025081688538193703,
-0.006724142003804445,
-0.00498593645170331,
0.005211757495999336,
-0.015615707263350487,
-0.006901656277477741,
-0.008148115128278732,
0.01657658815383911,
-0.029779210686683655,
0.010656209662556648,
-0.043060362339019775,
-0.002256370149552822,
-0.024117600172758102,
0.0026994599029421806,
0.014856992289423943,
0.007808740250766277,
0.005663793068379164,
0.01386113092303276,
0.041328348219394684,
-0.01134753879159689,
0.025277964770793915,
-0.002225537784397602,
0.0028571123257279396,
0.004695534706115723,
-0.024512162432074547,
0.010310088284313679,
-0.0003464238252490759,
-0.0202249214053154,
0.022816848009824753,
-0.007478062063455582,
-0.01933952234685421,
-0.0039363643154501915,
-0.008430907502770424,
0.0018421392887830734,
-0.019825324416160583,
-0.008899682201445103,
-0.012510390020906925,
-0.009080205112695694,
0.008662616834044456,
0.04456275701522827,
0.005530457943677902,
0.021280011162161827,
0.02725628949701786,
-0.013805054128170013,
-0.010125305503606796,
0.010243069380521774,
0.002834492363035679,
0.01572982780635357,
0.010790924541652203,
-0.024955186992883682,
-0.016080647706985474,
0.004841404967010021,
0.024805869907140732,
0.02546006441116333,
0.01680745556950569,
-0.012679776176810265,
0.024092040956020355,
-0.02171028032898903,
-0.0024049226194620132,
-0.013461042195558548,
0.026038091629743576,
-0.0005137361586093903,
0.007496466860175133,
-0.009353098459541798,
0.0024537271820008755,
0.04460277408361435,
0.008185641840100288,
-0.039450354874134064,
0.010821279138326645,
0.012430916540324688,
0.011905854567885399,
-0.03149247169494629,
-0.001813497394323349,
-0.02337067201733589,
-0.01076197437942028,
-0.0012610971461981535,
0.024551747366786003,
-0.018231384456157684,
0.006173298694193363,
0.011826355010271072,
0.004205175209790468,
-0.011939655989408493,
-0.03586176782846451,
0.008484985679388046,
0.02531685307621956,
0.009634772315621376,
-0.014838861301541328,
0.005853466689586639,
0.007804594933986664,
-0.00831347331404686,
-0.011704923585057259,
-0.08082892745733261,
-0.007504778914153576,
-0.0163891538977623,
-0.013015790842473507,
0.009794186800718307,
-0.0064564174972474575,
-0.00597701221704483,
0.006810852792114019,
-0.014780769124627113,
-0.016841523349285126,
0.020258817821741104,
-0.0012768534943461418,
-0.009180312044918537,
-0.0018146676011383533,
-0.027574945241212845,
-0.009747427888214588,
0.011781426146626472,
-0.01923033595085144,
-0.023357240483164787,
-0.03091306984424591,
-0.0035836617462337017,
0.0023361649364233017,
0.011186165735125542,
0.007980295456945896,
-0.0010811008978635073,
-0.026695916429162025,
0.004325335845351219,
0.0008265860378742218,
-0.006933788303285837,
0.002452349290251732,
-0.024036511778831482,
-0.02770412713289261,
0.006696227006614208,
-0.02426661178469658,
-0.026511263102293015,
0.0033378247171640396,
-0.004809268284589052,
0.006027834489941597,
-0.027132149785757065,
0.050059206783771515,
0.006363189313560724,
0.00004275480750948191,
0.024978473782539368,
-0.003127642208710313,
0.018616408109664917,
0.013730917125940323,
0.0034133237786591053,
0.021006068214774132,
0.014357560314238071,
-0.006306263618171215,
-0.014851465821266174,
0.017493491992354393,
-0.03299010172486305,
0.025496982038021088,
-0.00417269067838788,
0.004340922459959984,
0.010603860951960087,
0.00034432392567396164,
-0.008862888440489769,
-0.023577824234962463,
-0.006958325393497944,
0.014076529070734978,
-0.01489156112074852,
0.019528482109308243,
-0.013772627338767052,
0.005413906183093786,
0.024954671040177345,
0.006654717028141022,
-0.01186307892203331,
0.01655505783855915,
0.0063313692808151245,
-0.02145654708147049,
-0.014628486707806587,
-0.005242852959781885,
0.008681269362568855,
-0.015394264832139015,
-0.017861131578683853,
-0.010766629129648209,
0.00883475225418806,
-0.006205699872225523,
0.00318730715662241,
0.012280290946364403,
0.0015772648621350527,
0.0014905366115272045,
-0.013678560964763165,
-0.013875186443328857,
0.0048564705066382885,
0.027791161090135574,
0.023658007383346558,
-0.0097793098539114,
-0.02244499884545803,
0.03301269933581352,
-0.022787708789110184,
0.011046048253774643,
-0.015263541601598263,
-0.04190773516893387,
-0.02800566703081131,
0.0052546486258506775,
0.02381099946796894,
0.011674266308546066,
-0.006427454762160778,
0.0057566212490201,
0.002687131054699421,
-0.0064118048176169395,
-0.016121357679367065,
0.014762992039322853,
-0.01932971365749836,
0.0075776949524879456,
0.0041517275385558605,
-0.005910058505833149,
0.013153024017810822,
0.015848275274038315,
-0.006527721881866455,
0.03201419115066528,
0.007370154373347759,
0.004968387074768543,
0.00035537569783627987,
0.01418706402182579,
0.0716140940785408,
0.012282121926546097,
0.004583442583680153,
-0.028723973780870438,
0.012409834191203117,
-0.010375595651566982,
0.0020381335634738207,
-0.002877306193113327,
-0.007521548308432102,
0.014704752713441849,
0.01265212893486023,
-0.04060085490345955,
0.031375449150800705,
0.0023667169734835625,
-0.018209584057331085,
-0.0018259672215208411,
-0.012514330446720123,
-0.005768093280494213,
0.003072921186685562,
-0.008542707189917564,
-0.00025679823011159897,
-0.05931016802787781,
0.015375989489257336,
-0.027520420029759407,
0.004359902814030647,
0.01043223962187767,
0.030448932200670242,
-0.013607853092253208,
-0.004136236384510994,
0.014761758036911488,
-0.011066107079386711,
-0.007556104566901922,
-0.0050967056304216385,
0.04573892056941986,
0.012957904487848282,
-0.009959537535905838,
0.025646358728408813,
0.010108914226293564,
-0.013459082692861557,
0.005558024160563946,
0.002373974770307541,
-0.017068704590201378,
0.006566321011632681,
0.007790121249854565,
-0.010495912283658981,
0.012995904311537743,
0.040837567299604416,
-0.00949525274336338,
0.014643128030002117,
0.013198516331613064,
-0.02616191655397415,
-0.015445012599229813,
0.017732473090291023,
0.02037046104669571,
-0.008520464412868023,
-0.014384428039193153,
0.025092341005802155,
-0.008405730128288269,
0.02959788218140602,
0.0030431943014264107,
-0.03300923854112625,
-0.025299709290266037,
0.043792806565761566,
-0.018988728523254395,
0.004651025868952274,
-0.014900078997015953,
-0.016586128622293472,
-0.022119814530014992,
-0.016019731760025024,
0.014168215915560722,
0.024433396756649017,
0.008443823084235191,
0.0217773225158453,
0.010777893476188183,
-0.02455522119998932,
0.036547690629959106,
-0.016889888793230057,
-0.013341063633561134,
0.026570230722427368,
-0.02093450352549553,
-0.01755417510867119,
0.012553125619888306,
0.01866479218006134,
0.011766696348786354,
0.025450415909290314,
-0.010700673796236515,
-0.012960241176187992,
-0.07419891655445099,
-0.027125978842377663,
0.004786299541592598,
-0.010952051728963852,
-0.001145453890785575,
-0.009958929382264614,
-0.021217171102762222,
-0.006545515730977058,
0.009674661792814732,
-0.0015224646776914597,
-0.010552458465099335,
0.010673780925571918,
0.01337864063680172,
-0.010518068447709084,
0.012655679136514664,
-0.006553780287504196,
-0.0034708494786173105,
0.004770803730934858,
-0.006350873503834009,
-0.016936231404542923,
0.014221390709280968,
-0.00908804964274168,
-0.0310463085770607,
0.007283252198249102,
-0.014017092064023018,
-0.08038671314716339,
-0.002699654782190919,
0.004589051939547062,
-0.00948050245642662,
-0.018100444227457047,
0.018385931849479675,
0.0000943327322602272,
-0.012547709047794342,
-0.027247723191976547,
-0.016883937641978264,
0.007242090534418821,
0.03006657585501671,
0.0024727799464017153,
-0.020465591922402382,
0.017275074496865273,
-0.011689660139381886,
0.0001822258927859366,
0.01640486903488636,
0.008489236235618591,
-0.02909991331398487,
-0.023320499807596207,
0.028279662132263184,
-0.010818831622600555,
-0.02889382466673851,
-0.011750023812055588,
0.004251610487699509,
-0.0018466900801286101,
0.01616804301738739,
-0.013536844402551651,
-0.022794857621192932,
0.002441157354041934,
-0.004187908489257097,
-0.01731516607105732,
-0.019006602466106415,
-0.00008784700185060501,
-0.02561156451702118,
-0.007567618973553181,
0.01024927943944931,
-0.02794385328888893,
-0.012866529636085033,
-0.0042315516620874405,
0.042830802500247955,
-0.004632823169231415,
0.02036251686513424,
0.0002951878122985363,
-0.008909876458346844,
0.0035935970954596996,
-0.01406472735106945,
0.020359080284833908,
0.024513404816389084,
0.005419397726655006,
-0.0037320745177567005,
0.01560845598578453,
0.0030805692076683044,
0.028745554387569427,
0.027786947786808014,
-0.019422341138124466,
0.032634638249874115,
0.02625366859138012,
-0.0027954643592238426,
-0.004252579063177109,
-0.00047490024007856846,
-0.01994144544005394,
0.07164035737514496,
0.005384661722928286,
0.00956012587994337,
-0.036905527114868164,
-0.0036897354293614626,
0.001990837976336479,
0.01273538637906313,
0.0010673189535737038,
0.0004205619916319847,
-0.011922961100935936,
-0.008577777072787285,
-0.016588276252150536,
-0.0001854095607995987,
0.015201748348772526,
0.012020738795399666,
-0.0068369535729289055,
0.00947643257677555,
-0.0012309635058045387,
-0.023272467777132988,
0.035060446709394455,
-0.019382424652576447,
0.017391903325915337,
-0.0026598358526825905,
0.0009163902141153812,
0.025340722873806953,
-0.00894121266901493,
0.001189438160508871,
-0.0038722502067685127,
-0.018906863406300545,
0.00508075812831521,
-0.0032451890874654055,
-0.00720859132707119,
-0.00554685527458787,
-0.008979516103863716,
0.02878815308213234,
0.012195320799946785,
0.0035314434207975864,
0.009521123953163624,
-0.013530302792787552,
-0.009603743441402912,
-0.014870493672788143,
-0.0035000471398234367,
0.005425833631306887,
-0.0017350856214761734,
0.012705177068710327,
0.002313263714313507,
0.015480712056159973,
0.01193046011030674,
0.016742270439863205,
-0.006097939796745777,
-0.002620202722027898,
-0.00812686886638403,
-0.0012998217716813087,
0.02152542769908905,
0.02300053834915161,
0.0301082544028759,
-0.02829691767692566,
0.014326663687825203,
-0.014341125264763832,
-0.0006659065838903189,
0.016397226601839066,
-0.021972954273223877,
0.001169686671346426,
-0.02745683677494526,
0.009082413278520107,
0.0069103483110666275,
0.003667159005999565,
-0.018301408737897873,
-0.007432777434587479,
0.019061949104070663,
-0.025959188118577003,
0.003022504970431328,
0.012785980477929115,
0.023992067202925682,
0.027403127402067184,
0.021599026396870613,
-0.0007325855549424887,
0.006399897392839193,
0.010690290480852127,
0.010876817628741264,
-0.014467725530266762,
0.017477594316005707,
0.008075343444943428,
0.012887170538306236,
-0.015826327726244926,
0.029458846896886826,
0.00132473255507648,
0.03727707266807556,
0.006224782206118107,
0.0071190111339092255,
0.024924959987401962,
0.009132563136518002,
0.004393802955746651,
-0.01395018957555294,
0.00602326076477766,
0.034030184149742126,
0.02143779769539833,
0.0017557854298502207,
-0.008597156964242458,
0.008740992285311222,
-0.012153493240475655,
-0.030345089733600616,
-0.03445391356945038,
0.02475585602223873,
-0.010097838938236237,
-0.0020622338633984327,
0.002476687543094158,
-0.017154313623905182,
0.004782131873071194,
0.007565383333712816,
0.03543561324477196,
0.02344970405101776,
0.045319002121686935,
-0.007046311162412167,
-0.008362230844795704,
0.019468635320663452,
-0.0274222232401371,
-0.014633558690547943,
-0.013953433372080326,
-0.014710536226630211,
-0.0290728360414505,
-0.0094191525131464,
0.0006491579115390778,
0.0025518073234707117,
0.004761793185025454,
-0.01567710191011429,
-0.015159672126173973,
0.016856886446475983,
-0.0024398593232035637,
0.00950593501329422,
0.015524364076554775,
0.010228995233774185,
-0.04152127355337143,
0.034348923712968826,
0.007338493596762419,
0.011938822455704212,
-0.016080526635050774,
0.010011177510023117,
-0.015777770429849625,
0.020619211718440056,
0.035545140504837036,
-0.008442063815891743,
0.006650787778198719,
-0.008466517552733421,
0.0077395010739564896,
-0.0012026522308588028,
0.033081963658332825,
0.020304635167121887,
0.01094816904515028,
-0.017529645934700966,
0.0015108578372746706,
0.02092258632183075,
0.0014685620553791523,
-0.005357229150831699,
0.021890152245759964,
0.01759708859026432,
-0.0007563772378489375,
-0.02866729348897934,
-0.018840041011571884,
0.010837798938155174,
0.022699033841490746,
0.0037028836086392403,
0.003523724153637886,
-0.011524348519742489,
0.02906261570751667,
0.012963797897100449,
-0.007786269299685955,
0.01908954419195652,
-0.013031733222305775,
-0.0009754926431924105,
0.024230249226093292,
0.016156572848558426,
-0.01804237999022007,
-0.011857371777296066,
-0.02646007016301155,
-0.004336894489824772,
-0.021906647831201553,
0.019941138103604317,
0.009574780240654945,
0.012202268466353416,
0.033694587647914886,
-0.019215110689401627,
-0.01499059610068798,
-0.00932115688920021,
-0.015739651396870613,
-0.010449908673763275,
-0.006670008413493633,
0.001235701609402895,
0.003520616563037038,
0.012500405311584473,
-0.025301598012447357,
0.024502694606781006,
-0.0027173953130841255,
-0.00023218011483550072,
-0.008697548881173134,
-0.019715433940291405,
0.0033520152792334557,
0.0074684470891952515,
0.0040741912089288235,
0.016467036679387093,
0.031224660575389862,
-0.0011580288410186768
] | [
-0.0712476596236229,
0.0984126627445221,
0.27141740918159485,
0.007167074829339981,
0.0798916295170784,
0.028126006945967674,
0.22706244885921478,
-0.24904169142246246,
-0.09390509873628616,
-0.5734783411026001,
0.028032759204506874,
0.08435595035552979,
-0.4285764992237091,
0.46201515197753906,
0.1406562626361847,
0.9266113638877869,
0.2014908343553543,
0.5357820987701416,
-0.35610413551330566,
-0.6411067247390747,
0.13009682297706604,
-0.2952940762042999,
0.2865588665008545,
-0.2876170873641968,
0.2513648569583893,
-0.11569640785455704,
0.6463758945465088,
-0.12680748105049133,
0.28890106081962585,
-0.22625163197517395,
-0.08138224482536316,
0.5215306878089905,
-0.010880704037845135,
-0.40733087062835693,
-0.19331763684749603,
-0.10634344816207886,
-0.31816378235816956,
0.0697852149605751,
0.08433739095926285,
0.18457362055778503,
-0.5403535962104797,
-0.24779057502746582,
-0.03706590458750725,
0.5640879273414612,
0.11687661707401276,
-0.4207197427749634,
-1.466660976409912,
0.6321918368339539,
-0.28043362498283386,
-0.1424843668937683,
-0.09041757881641388,
0.18114659190177917,
0.23097079992294312,
0.03513839468359947,
0.36437904834747314,
0.47120434045791626,
-0.5967934727668762,
-0.15999318659305573,
0.18846416473388672,
-0.41285040974617004,
-0.17197886109352112,
0.019868342205882072,
-0.5825898051261902,
0.17773672938346863,
-0.009528717026114464,
0.7379072308540344,
0.08973503112792969,
-0.413184255361557,
-0.8982131481170654,
-0.4400388300418854,
0.4249325096607208,
-0.3123413324356079,
-0.1283428817987442,
0.3675963878631592,
0.2600657641887665,
-0.03396938741207123,
-0.3526304364204407,
-0.3158666789531708,
0.3268715739250183,
-0.2185325175523758,
0.48381558060646057,
-0.27421706914901733,
0.21071067452430725,
0.24029813706874847,
0.34810733795166016,
0.21515685319900513,
-0.08153899013996124,
0.393356591463089,
-0.6283277869224548,
-0.46503427624702454,
-0.2590981423854828,
-0.054708268493413925,
0.46166735887527466,
0.723588764667511,
0.5570738911628723,
0.28958186507225037,
-0.3738798201084137,
0.1838618665933609,
-0.32747000455856323,
0.652490496635437,
-0.5209115743637085,
0.12427962571382523,
-0.02925039641559124,
-0.12108784168958664,
-0.5158050656318665,
-0.4320211708545685,
-0.31896957755088806,
-0.6705068945884705,
-0.595976710319519,
0.41071805357933044,
-0.669510543346405,
0.27991783618927,
-0.3307795822620392,
-0.1941232830286026,
-0.16935241222381592,
-0.20904460549354553,
0.15436066687107086,
-0.20509886741638184,
0.15753944218158722,
0.15359696745872498,
-0.006857967935502529,
1.6430933475494385,
-0.22542604804039001,
0.48286956548690796,
0.14912447333335876,
-0.044963814318180084,
0.32866379618644714,
0.13213028013706207,
-0.2462902069091797,
0.510024905204773,
0.22068478167057037,
0.7973049879074097,
-0.6483107805252075,
-0.1393255740404129,
-0.008682288229465485,
-0.12121529132127762,
0.44663622975349426,
-0.04809300974011421,
0.08681438118219376,
0.11726167798042297,
-0.3569660782814026,
-0.5847285389900208,
-0.30866941809654236,
0.10749568045139313,
0.1174294576048851,
-0.3809046149253845,
-0.2078726440668106,
-0.01602362096309662,
-0.14835494756698608,
-0.06472789496183395,
-0.022441968321800232,
-0.42109400033950806,
-0.6233111619949341,
0.041668910533189774,
-0.12814852595329285,
0.779011070728302,
-0.043171342462301254,
-0.3696252703666687,
0.058410126715898514,
0.5218578577041626,
0.21885840594768524,
-0.12838521599769592,
-0.4606925845146179,
-0.22756491601467133,
0.527711033821106,
0.010099811479449272,
0.41435009241104126,
0.48373275995254517,
0.08232787251472473,
-0.15912698209285736,
-0.3363422453403473,
-0.2506183981895447,
0.16067692637443542,
-0.7296350002288818,
0.289084792137146,
-0.08929497003555298,
0.14222988486289978,
-0.09708139300346375,
-0.08993949741125107,
0.2115938812494278,
-0.8992986679077148,
-0.37089550495147705,
-0.609917938709259,
-0.23145395517349243,
0.06704584509134293,
0.24733732640743256,
0.8334243297576904,
-0.044496241956949234,
-0.2109806388616562,
0.078577421605587,
-0.3480388820171356,
-0.056973766535520554,
0.6226567625999451,
-0.5820225477218628,
1.3838953971862793,
0.0853336825966835,
-0.2580403983592987,
1.4823800325393677,
0.0158215444535017,
0.5656571984291077,
-0.5433581471443176,
-0.14904767274856567,
0.4651661515235901,
-0.0988926962018013,
-0.34026092290878296,
-0.010307380929589272,
-0.022580461576581,
-0.05556747689843178,
-0.1655704826116562,
0.410658597946167,
0.21550510823726654,
-0.31742072105407715,
-0.22079825401306152,
0.19472292065620422,
0.250261515378952,
-0.35326141119003296,
0.3210414946079254,
-0.29371628165245056,
-0.44512608647346497,
0.028271999210119247,
0.002484691794961691,
-0.7035582065582275,
0.7244464159011841,
0.8853152394294739,
-0.07465533167123795,
1.009827971458435,
0.5396218299865723,
0.3487623333930969,
0.5073155164718628,
-0.3707960247993469,
0.34941378235816956,
-0.41208118200302124,
0.5770414471626282,
-0.287081778049469,
-0.1901736855506897,
-0.12276298552751541,
0.15885351598262787,
0.2062869817018509,
0.15908995270729065,
-0.18007270991802216,
-0.08096197992563248,
0.30961740016937256,
-0.08586545288562775,
-0.17869915068149567,
0.052897777408361435,
-0.48656725883483887,
-0.2746032476425171,
0.4694242477416992,
-0.4930990934371948,
-0.22561269998550415,
0.4308692216873169,
0.1483122855424881,
-0.1246950700879097,
-0.9180301427841187,
-0.24957069754600525,
0.4080279767513275,
-0.29103991389274597,
-0.5693918466567993,
0.07475365698337555,
-0.4636188745498657,
-0.21083948016166687,
0.049123186618089676,
0.1596202850341797,
0.12353471666574478,
0.18384858965873718,
-0.25572577118873596,
-0.8109055757522583,
-0.32862821221351624,
1.0841690301895142,
0.5630825757980347,
0.4920448064804077,
0.013320794329047203,
-0.9881436228752136,
-0.2586476504802704,
-0.3584567904472351,
-0.3510104715824127,
-0.2335924655199051,
0.5393290519714355,
-0.49182215332984924,
-0.054528769105672836,
-0.07137401401996613,
0.11912155151367188,
0.9547890424728394,
-0.0002752613218035549,
-1.0082064867019653,
0.04851215332746506,
-0.07638939470052719,
-0.6763321161270142,
-0.8799166679382324,
-0.256791889667511,
-0.01733284816145897,
0.4527609944343567,
-0.5120510458946228,
-0.0344030037522316,
0.2103549987077713,
0.10667785257101059,
-0.380391925573349,
0.1195456013083458,
0.5964728593826294,
-0.17668364942073822,
-0.191224604845047,
0.14646629989147186,
-0.24352425336837769,
-0.28797584772109985,
-0.15607850253582,
0.009757181629538536,
-0.6221148371696472,
0.3165532052516937,
-5.822772979736328,
0.054562367498874664,
-0.2633969485759735,
0.2167208045721054,
-0.43591248989105225,
-0.4764966070652008,
1.177282691001892,
-0.13641105592250824,
0.6584281921386719,
0.14657406508922577,
0.3140262961387634,
0.44805026054382324,
-0.006361242383718491,
0.18662899732589722,
0.0031316939275711775,
0.1751794070005417,
-0.08471891283988953,
-0.4743509292602539,
1.01136314868927,
0.05841941758990288,
0.3614514470100403,
-0.20075297355651855,
-0.14574863016605377,
0.5132320523262024,
0.10747209936380386,
0.056137047708034515,
-1.0983927249908447,
0.009303868748247623,
-0.06699887663125992,
-0.2685900330543518,
0.027248047292232513,
-0.2791793644428253,
-0.3148557245731354,
-0.010885195806622505,
0.44526275992393494,
0.1719997078180313,
0.24540390074253082,
0.0871577039361,
-0.6366134881973267,
-0.26667413115501404,
0.803947925567627,
0.26505082845687866,
-0.3766847550868988,
0.17233842611312866,
0.38338395953178406,
-0.029390938580036163,
-0.24414832890033722,
0.4009381830692291,
-0.2638128101825714,
0.7071478366851807,
-0.22486330568790436,
-0.3641798496246338,
0.3261638283729553,
1.050542950630188,
0.20080780982971191,
0.2915099263191223,
-0.11770612746477127,
-0.22653591632843018,
-0.3486853241920471,
-0.01497568842023611,
-0.43930989503860474,
-0.2331267148256302,
-0.13940860331058502,
-0.37309274077415466,
0.4160197079181671,
0.2601350247859955,
-0.5496760010719299,
-0.6013979911804199,
0.13778714835643768,
-0.152611643075943,
-0.2558782696723938,
0.11947059631347656,
0.3018776476383209,
-0.7515987157821655,
0.6860114336013794,
-0.16833467781543732,
-0.0852910578250885,
0.13381311297416687,
-0.46001845598220825,
0.21036264300346375,
-0.3173382580280304,
-0.2802146375179291,
-0.13399499654769897,
0.18142655491828918,
0.29729095101356506,
-0.4782855808734894,
-0.023870913311839104,
0.05451513081789017,
0.06127353385090828,
0.5847470760345459,
0.30527034401893616,
-0.2635485827922821,
-0.035047758370637894,
0.34283268451690674,
0.2497754842042923,
0.20024780929088593,
0.5967912077903748,
0.21373437345027924,
0.45584914088249207,
0.25371837615966797,
0.46463990211486816,
0.11619681864976883,
-0.40212589502334595,
-1.0069540739059448,
0.2155950367450714,
0.4878106415271759,
-0.3194217383861542,
0.022889424115419388,
0.41608768701553345,
-0.748996913433075,
0.05416678264737129,
-0.06036077067255974,
-0.40846362709999084,
0.3480443060398102,
0.691401481628418,
-0.5937678813934326,
-0.06141107156872749,
-0.16054004430770874,
0.424048513174057,
-0.36402127146720886,
-0.2262181043624878,
0.22215025126934052,
-1.0509839057922363,
0.6531790494918823,
-0.2012675404548645,
-0.47361910343170166,
-0.10489393770694733,
0.7165389657020569,
-0.4281204044818878,
0.1725967675447464,
0.14653196930885315,
0.47869375348091125,
-0.5180352926254272,
-0.21601243317127228,
0.43656980991363525,
-0.45151206851005554,
-0.3271702527999878,
0.5813496112823486,
0.14812344312667847,
-0.33426806330680847,
0.28699401021003723,
-0.2666807174682617,
0.20665064454078674,
-0.1684173345565796,
0.2249029576778412,
0.24015900492668152,
0.37890344858169556,
0.018892396241426468,
-0.3371519446372986,
0.009253286756575108,
-0.3144114911556244,
-0.09609215706586838,
-0.0262089055031538,
0.0671079084277153,
0.0647360309958458,
0.2961808741092682,
0.44056203961372375,
0.5470215082168579,
0.3277575373649597,
-0.4600497782230377,
0.06615668535232544,
0.4383328855037689,
-0.886486828327179,
0.038015685975551605,
-0.01073930598795414,
-0.5827187299728394,
-0.26075589656829834,
-0.14100003242492676,
-0.14650113880634308,
0.11919291317462921,
-0.5180736780166626,
-0.08120119571685791,
0.004512878600507975,
0.13319113850593567,
0.22253689169883728,
-0.451590895652771,
-0.08937080949544907,
0.08917970955371857,
-0.22517624497413635,
-0.061313048005104065,
0.0008581900037825108,
-0.6378986835479736,
-0.2776148319244385,
0.22978903353214264,
0.3222333490848541,
0.2738291025161743,
-0.12283442169427872,
-0.44680553674697876,
-0.11989995837211609,
-0.5181477665901184,
0.09048248827457428,
0.2555338442325592,
0.5317632555961609,
-0.2267613261938095,
-0.007608627434819937,
0.05326446518301964,
0.17741921544075012,
0.34267595410346985,
0.30831122398376465,
-1.0010589361190796,
0.27096185088157654,
0.49251410365104675,
-0.24480707943439484,
0.518755316734314,
0.14429913461208344,
0.10303281247615814,
-0.10132778435945511,
0.18779858946800232,
-0.21371345221996307,
-0.2449672520160675,
-0.07336041331291199,
-0.7115549445152283,
0.12046574056148529,
0.4292927384376526,
0.04040631651878357,
0.00586816668510437,
0.39664167165756226,
0.20674872398376465,
0.023023949936032295,
0.3922750651836395,
0.43133488297462463,
-0.5009312033653259,
-0.01492984313517809,
0.055494144558906555,
-0.6350471377372742,
0.05729274824261665,
0.3468519151210785,
-0.6500890851020813,
0.21641941368579865,
0.258462131023407,
0.4868553876876831,
-0.20824910700321198,
-0.030645044520497322,
0.5435544848442078,
-0.18413950502872467,
-0.5241296291351318,
-0.8593615889549255,
0.3382660448551178,
-0.1369839757680893,
0.40976226329803467,
0.5005382895469666,
0.0895819365978241,
-0.43039336800575256,
0.013563917949795723,
-0.13940398395061493,
0.2999395728111267,
0.07337264716625214,
-0.36236003041267395,
-0.5118920803070068,
0.16604149341583252,
0.32799023389816284,
-0.027975479140877724,
0.32674744725227356,
0.3892729878425598,
1.1246787309646606,
0.22817794978618622,
0.08463311940431595,
-0.07589692622423172,
-0.4670039117336273,
0.6593080163002014,
-0.45238593220710754,
0.05209299549460411,
-0.2597678005695343,
-0.2365259826183319,
0.07551508396863937,
0.13985364139080048,
0.12383677810430527,
-0.9799106121063232,
0.4590584337711334,
0.19839459657669067,
-0.20302794873714447,
-0.03050258196890354,
0.6618347764015198,
0.36654868721961975,
-0.22071437537670135,
0.17152510583400726,
-0.39858880639076233,
0.5419076085090637,
-0.22303982079029083,
0.15160365402698517,
-0.026977432891726494,
-0.7247290015220642,
0.3344780206680298,
-0.9045282602310181,
0.013839781284332275,
-0.3357240855693817,
0.40674760937690735,
-0.25561803579330444,
0.23214058578014374,
-0.17840048670768738,
-0.25873956084251404,
0.3843918740749359,
-0.5653649568557739,
-0.5132806897163391,
0.02476280927658081,
0.07114698737859726,
-0.08003969490528107,
0.010887185111641884,
0.05354481190443039,
-0.24981802701950073,
-0.234035924077034,
0.34429842233657837,
0.5188853740692139,
-0.1645086109638214,
-0.3256702721118927,
0.07511107623577118,
0.37210336327552795,
0.42436012625694275,
-0.3700083792209625,
-0.05780826508998871,
0.05492793023586273,
0.07131630927324295,
0.6516483426094055,
-0.1022871732711792,
-0.09742200374603271,
0.4572583734989166,
0.10719168186187744,
-0.033463481813669205,
0.2860587239265442,
0.03484875336289406,
0.2862960994243622,
0.48393112421035767,
0.32698550820350647,
-0.08549699187278748,
-0.5519058108329773,
0.22721286118030548,
0.20227552950382233,
0.38615256547927856,
0.15206125378608704,
0.3393632769584656,
0.2630683481693268,
0.2973993718624115,
-0.18120679259300232,
0.8432414531707764,
0.4535055160522461,
0.17422018945217133,
0.10230430960655212,
-0.5869641900062561,
-0.13165991008281708,
-0.38563209772109985,
0.8925327658653259,
0.6912035942077637,
-0.40320390462875366,
-0.33624106645584106,
0.4787684977054596,
0.07584074139595032,
-0.10613840818405151,
0.08766243606805801,
-0.38502180576324463,
0.41219475865364075,
-0.05555938556790352,
-0.4079740047454834,
-0.7333695292472839,
0.28871646523475647,
-0.41774287819862366,
0.15128028392791748,
0.5525388717651367,
-0.4429056942462921,
-0.30689093470573425,
-0.0002715947921387851,
-0.37649035453796387,
0.16450519859790802,
-0.24365347623825073,
0.6680184602737427,
-0.49405917525291443,
0.007476194761693478,
0.6565110087394714,
0.35539770126342773,
0.26206931471824646,
-0.07372651994228363,
0.032325997948646545,
-0.19784323871135712,
0.3513867259025574,
0.32984164357185364,
0.2120169699192047,
-0.3554514944553375,
0.357911616563797,
-0.5910001993179321,
0.04719027131795883,
0.38749969005584717,
-0.2656451165676117,
0.18097469210624695,
-0.22964301705360413,
-0.530482828617096,
-0.2005474716424942,
-0.3909684419631958,
-0.36231568455696106,
-0.10807078331708908,
-0.05517646297812462,
-0.08349242806434631,
0.0643739253282547,
-0.6406968832015991,
0.20034795999526978,
0.0514976866543293,
-0.11280632019042969,
-0.18220917880535126,
-0.10129669308662415,
0.21908538043498993,
0.2768131196498871,
0.41063153743743896,
0.11829422414302826,
0.0670149102807045,
0.1061529889702797,
0.6223776936531067,
-0.5686610341072083,
0.447361022233963,
-0.4737088978290558,
-0.1137119010090828,
-0.6407580375671387,
-0.34755921363830566,
0.9004095196723938,
0.6449280381202698,
-0.21606431901454926,
-0.16878551244735718,
0.0993974432349205,
-0.01135905459523201,
0.32167643308639526,
-0.6103637218475342,
0.2958313226699829,
-0.6163522005081177,
-0.0030973481480032206,
-0.6484339237213135,
0.6507537961006165,
-0.06118432432413101,
-0.45706048607826233,
-0.0014428829308599234,
0.44199317693710327,
0.46098220348358154,
0.33194324374198914,
0.23321297764778137,
0.09949196130037308,
-0.04189591109752655,
-0.3714860677719116,
0.547523021697998,
-0.26029303669929504,
0.13783003389835358,
-0.7017804980278015,
0.40024691820144653,
-0.030873430892825127,
-0.2599834203720093,
-0.16191315650939941,
-0.17418470978736877,
-0.17184075713157654,
-0.14614365994930267,
0.255921334028244,
0.051777880638837814,
-0.3577699363231659,
-1.031165361404419,
-0.20812630653381348,
0.35008108615875244,
0.2083510458469391,
0.018662137910723686,
-0.34440866112709045,
0.3455118238925934,
0.133250430226326,
0.045118238776922226,
-0.15943534672260284,
-0.6419816613197327,
-0.1514647752046585,
-0.1854480504989624
] |
BACKGROUND Steroidogenic acute regulatory (StAR) protein related lipid transfer (START) domains are small globular modules that form a cavity where lipids and lipid hormones bind. These domains can transport ligands to facilitate lipid exchange between biological membranes, and they have been postulated to modulate the activity of other domains of the protein in response to ligand binding. More than a dozen human genes encode START domains, and several of them are implicated in a disease. PRINCIPAL FINDINGS We report crystal structures of the human STARD1, STARD5, STARD13 and STARD14 lipid transfer domains. These represent four of the six functional classes of START domains. SIGNIFICANCE Sequence alignments based on these and previously reported crystal structures define the structural determinants of human START domains, both those related to structural framework and those involved in ligand specificity. ENHANCED VERSION This article can also be viewed as an enhanced version in which the text of the article is integrated with interactive 3D representations and animated transitions. Please note that a web plugin is required to access this enhanced functionality. Instructions for the installation and use of the web plugin are available in Text S1. | [
-0.008618632331490517,
0.010371512733399868,
0.004823129624128342,
0.01263162586838007,
0.046525225043296814,
-0.008190557360649109,
0.009166644886136055,
0.038328807801008224,
-0.011737767606973648,
0.008592908270657063,
-0.004642237909138203,
0.004436085931956768,
0.0031425384804606438,
0.02451103925704956,
0.032839927822351456,
0.023860089480876923,
-0.01165978517383337,
-0.002837591338902712,
0.009343375451862812,
0.018827002495527267,
0.015408305451273918,
-0.011635182425379753,
0.009517360478639603,
0.012184502556920052,
0.0010029866825789213,
-0.019888481125235558,
-0.0096672922372818,
-0.005879133474081755,
-0.0366097018122673,
0.005076165311038494,
-0.011234953999519348,
0.022990062832832336,
-0.0034233885817229748,
-0.008099760860204697,
0.002641565864905715,
-0.008337864652276039,
-0.009454069659113884,
0.01598050631582737,
-0.0020400818902999163,
-0.004186949692666531,
0.028969615697860718,
-0.009459706954658031,
-0.0020369403064250946,
0.00894559733569622,
-0.009774920530617237,
-0.014785975217819214,
-0.002993545029312372,
0.01141781359910965,
-0.01838402822613716,
0.0022252665366977453,
-0.007935130037367344,
0.013522198423743248,
-0.0046553704887628555,
0.008387507870793343,
-0.005498695187270641,
0.0005290261469781399,
0.01799212396144867,
-0.019823042675852776,
-0.006389658898115158,
0.027924856171011925,
0.001823879312723875,
0.021750781685113907,
0.02913482114672661,
0.0030546952039003372,
0.007166288793087006,
-0.06691840291023254,
0.025247137993574142,
0.005606471560895443,
-0.018697727471590042,
0.0018379357643425465,
-0.0022501724306493998,
0.00142083247192204,
0.012886567041277885,
-0.016806401312351227,
-0.015879539772868156,
-0.007444496266543865,
-0.019985370337963104,
0.024378623813390732,
0.03761927783489227,
0.0034118094481527805,
0.006905282381922007,
0.02359052374958992,
-0.012929815798997879,
0.002212566090747714,
0.0025281901471316814,
-0.004133976064622402,
-0.01026533916592598,
-0.007082595955580473,
0.000616277102380991,
-0.033964790403842926,
0.01402302272617817,
-0.019765648990869522,
-0.04039010405540466,
-0.008454663679003716,
-0.014956350438296795,
-0.01329980231821537,
-0.011159604415297508,
-0.016234170645475388,
0.027983171865344048,
-0.00739697739481926,
-0.022243373095989227,
-0.01022409088909626,
0.012160032987594604,
-0.005780353210866451,
0.0028875679709017277,
0.014186928980052471,
0.02120683155953884,
-0.009781385771930218,
-0.005895268637686968,
0.011341238394379616,
-0.015998845919966698,
-0.0001916857436299324,
-0.01487660687416792,
0.02170369029045105,
-0.010976113379001617,
0.015367726795375347,
0.0024048462510108948,
0.013205376453697681,
0.016112070530653,
0.017631778493523598,
0.011489353142678738,
0.00741981016471982,
-0.0002840929082594812,
-0.0021888408809900284,
0.012807593680918217,
0.002463008975610137,
-0.030207641422748566,
0.011419418267905712,
0.0025873277336359024,
0.017631016671657562,
-0.006691014394164085,
0.001426970586180687,
-0.0059079816564917564,
-0.01002089586108923,
-0.026022113859653473,
0.007435937412083149,
-0.006262645591050386,
0.004852942191064358,
0.00437925523146987,
-0.014883396215736866,
0.018541600555181503,
0.008671664632856846,
0.006484176032245159,
0.014121120795607567,
0.0387551411986351,
-0.0033668940886855125,
0.008763049729168415,
-0.01958419382572174,
0.002619364997372031,
-0.00015243736561387777,
-0.010633614845573902,
-0.01457778736948967,
0.016254600137472153,
-0.026983318850398064,
0.017843369394540787,
0.014531904831528664,
0.004019733052700758,
-0.002630230039358139,
0.0027561255265027285,
0.03784012049436569,
-0.02967369742691517,
0.01137290894985199,
0.004892531782388687,
0.008245117962360382,
-0.016489528119564056,
0.012185255065560341,
0.04518689215183258,
-0.007366219535470009,
0.020086342468857765,
0.006327817216515541,
-0.008756219409406185,
-0.02670217864215374,
-0.009394333697855473,
0.007860833778977394,
-0.010949799790978432,
-0.00550272548571229,
-0.003937682136893272,
0.008693039417266846,
-0.024855051189661026,
0.06631302833557129,
-0.005237485282123089,
-0.007123685907572508,
0.017531948164105415,
-0.008958806283771992,
0.0014413800090551376,
0.016649294644594193,
-0.0005306676030158997,
-0.015227455645799637,
-0.011720535345375538,
-0.026630710810422897,
0.03320804983377457,
-0.05011865496635437,
-0.015736950561404228,
0.012814199551939964,
0.01111646182835102,
0.0021966437343508005,
0.021467424929142,
-0.007986065000295639,
-0.015220257453620434,
-0.012620436027646065,
0.027200404554605484,
-0.010019326582551003,
0.03480351343750954,
-0.0013195916544646025,
0.010259746573865414,
-0.001525221741758287,
-0.014550531283020973,
-0.007001104764640331,
-0.014286046847701073,
-0.0025168429128825665,
0.020563092082738876,
0.005477460101246834,
-0.0150663573294878,
-0.016292905434966087,
-0.018466774374246597,
0.007001149468123913,
-0.007300513330847025,
0.0028804524336010218,
0.01781458780169487,
-0.010002183727920055,
-0.005484020337462425,
0.0003030756488442421,
-0.010543562471866608,
0.0035974455531686544,
0.025522559881210327,
-0.0017553677316755056,
-0.006480286829173565,
0.016042405739426613,
-0.012511610984802246,
0.011315685696899891,
0.006605855654925108,
-0.019009612500667572,
-0.011454792693257332,
0.01973854936659336,
0.009814025834202766,
-0.016636917367577553,
0.01154218427836895,
0.0019372589886188507,
0.007617308292537928,
-0.004912524484097958,
-0.013539178296923637,
-0.028574924916028976,
-0.011234642937779427,
-0.013173617422580719,
-0.021076884120702744,
0.0017469724407419562,
-0.00823664478957653,
0.014585297554731369,
-0.020885054022073746,
-0.026022175326943398,
0.009682608768343925,
0.009352147579193115,
-0.0074800122529268265,
0.014313221909105778,
-0.0008034594357013702,
0.022434573620557785,
0.022216979414224625,
-0.010487711057066917,
0.020771432667970657,
-0.027056658640503883,
0.0047215973027050495,
0.005893967114388943,
-0.008949513547122478,
-0.016528822481632233,
-0.009198136627674103,
0.00014632334932684898,
-0.014691432937979698,
0.03853665292263031,
-0.03058282472193241,
0.012293621897697449,
0.010995455086231232,
-0.002635825192555785,
-0.001687327167019248,
-0.08048023283481598,
-0.010565771721303463,
0.00000869017094373703,
0.004749922081828117,
0.011173888109624386,
0.019626032561063766,
-0.022203810513019562,
-0.020969752222299576,
-0.012472054921090603,
0.009656420908868313,
0.01616191305220127,
0.04252348467707634,
-0.018740840256214142,
-0.020599577575922012,
0.020387208089232445,
-0.008816288784146309,
0.009215226396918297,
-0.017779923975467682,
0.006006559357047081,
-0.02673797309398651,
-0.019969448447227478,
-0.016834761947393417,
-0.018780900165438652,
0.0063736531883478165,
-0.01214222889393568,
0.0024412088096141815,
-0.007211215794086456,
-0.018227901309728622,
-0.012830818071961403,
0.0022983483504503965,
-0.014518609270453453,
-0.016978152096271515,
0.058139901608228683,
-0.038974612951278687,
0.036809079349040985,
-0.016130387783050537,
0.009162131696939468,
-0.01310837920755148,
-0.007825825363397598,
-0.0009017738047987223,
0.0023947469890117645,
0.030488967895507812,
-0.008235061541199684,
0.011156877502799034,
0.0007075108587741852,
-0.004312889184802771,
0.0038065447006374598,
-0.0033437293022871017,
0.013782160356640816,
-0.008147450163960457,
0.01998729072511196,
0.0014948531752452254,
0.011745104566216469,
0.017729299142956734,
-0.0034529929980635643,
-0.008184482343494892,
-0.0200900100171566,
0.04442153871059418,
-0.012814663350582123,
-0.011152181774377823,
-0.017091957852244377,
-0.022858861833810806,
0.018895132467150688,
0.03323189169168472,
0.03109157457947731,
0.008992772549390793,
0.0029305675998330116,
-0.0025922181084752083,
0.001289373729377985,
0.006890123710036278,
0.023744236677885056,
0.005647958256304264,
0.018274258822202682,
-0.0011902389815077186,
0.002003298606723547,
-0.012281790375709534,
-0.014425316825509071,
0.0018833753420040011,
0.003998164553195238,
-0.03602273389697075,
-0.0143834687769413,
0.009839009493589401,
-0.022325633093714714,
0.00175953540019691,
-0.02921936847269535,
-0.02244989201426506,
0.00631177332252264,
0.005522953346371651,
0.00021029968047514558,
-0.012541906908154488,
0.047647058963775635,
-0.01597381755709648,
0.021074511110782623,
0.007295805960893631,
-0.0025878148153424263,
-0.021052848547697067,
-0.0028182307723909616,
0.00789626408368349,
-0.017473183572292328,
0.007954593747854233,
-0.03860275447368622,
0.010002529248595238,
-0.031805168837308884,
-0.017515644431114197,
-0.01637927256524563,
0.017380576580762863,
-0.003995552659034729,
0.01247516181319952,
0.0013459648471325636,
-0.0011727570090442896,
-0.026342373341321945,
0.012544829398393631,
-0.007729202508926392,
0.018706731498241425,
0.005445144604891539,
0.016413073986768723,
-0.03400257229804993,
-0.010815604589879513,
0.07238081097602844,
0.0039050662890076637,
-0.00799734890460968,
-0.016928335651755333,
0.016475465148687363,
-0.041432224214076996,
0.0009100772440433502,
-0.01768774352967739,
-0.03531823307275772,
0.027199706062674522,
0.009302599355578423,
0.018587660044431686,
0.022981610149145126,
-0.01826169528067112,
-0.02427731081843376,
-0.014968548901379108,
-0.04908248782157898,
0.0019071695860475302,
0.00036551477387547493,
0.004616345278918743,
-0.01776215061545372,
-0.023150306195020676,
0.0020069542806595564,
0.008692052215337753,
0.006539440713822842,
-0.027467302978038788,
-0.004274615552276373,
-0.011989705264568329,
-0.01898968033492565,
0.01040640939027071,
0.03217463940382004,
-0.03264344111084938,
-0.0067896973341703415,
0.0019230719190090895,
0.004324434790760279,
0.006664391607046127,
0.02264297567307949,
-0.007957478985190392,
0.003383887931704521,
0.0052052768878638744,
0.013329537585377693,
-0.014453785493969917,
0.01446630246937275,
0.016297485679388046,
-0.006271874066442251,
0.014767404645681381,
-0.0063392240554094315,
-0.006547918543219566,
-0.0004346633795648813,
-0.011966370046138763,
-0.01412174105644226,
0.013913800939917564,
0.012676786631345749,
0.028298135846853256,
0.004341334104537964,
-0.03559812903404236,
-0.0226295106112957,
0.0006800745613873005,
0.0027795115020126104,
0.011892994865775108,
-0.028215419501066208,
0.024435605853796005,
0.02382691204547882,
-0.014666947536170483,
0.009280413389205933,
-0.012958584353327751,
-0.010341037064790726,
-0.004018227104097605,
-0.02419389970600605,
0.012561568059027195,
0.013288203626871109,
-0.008005553856492043,
-0.012788206338882446,
-0.01827958971261978,
-0.02457481250166893,
-0.020632373169064522,
0.026058200746774673,
0.007190569769591093,
-0.0029121313709765673,
-0.02660966105759144,
0.011199097149074078,
0.02496098354458809,
0.012587681412696838,
0.009793149307370186,
-0.002711075358092785,
0.018696460872888565,
-0.039478402584791183,
-0.07407566905021667,
0.015503672882914543,
-0.005235256161540747,
-0.004147646948695183,
-0.004138416610658169,
0.019436635076999664,
-0.004331888165324926,
0.014224027283489704,
-0.008745111525058746,
-0.009984616190195084,
-0.00935983657836914,
-0.03834877163171768,
0.033012520521879196,
0.0004898528568446636,
0.013399682939052582,
0.0015051572117954493,
0.006202911492437124,
-0.006422250531613827,
-0.010663212276995182,
0.004033301025629044,
-0.010354815050959587,
-0.006946853827685118,
-0.025156565010547638,
-0.0017784193623811007,
-0.005216267891228199,
-0.0810997486114502,
-0.010562904179096222,
-0.011691689491271973,
-0.013061592355370522,
0.013224538415670395,
-0.03031410649418831,
0.028565458953380585,
-0.012036929838359356,
-0.006728538312017918,
-0.015866238623857498,
-0.005338510498404503,
0.0028031852561980486,
-0.015099164098501205,
-0.02065815031528473,
0.005168597213923931,
-0.007872447371482849,
0.01746843010187149,
0.00892687775194645,
0.004263836424797773,
0.0072326879017055035,
-0.00838437955826521,
0.011581896804273129,
-0.01473065372556448,
0.006539603229612112,
-0.005289268214255571,
-0.019960809499025345,
-0.01593557372689247,
0.009784508496522903,
0.012128740549087524,
0.012629451230168343,
-0.01962883397936821,
0.0006312550976872444,
-0.019528890028595924,
0.004788307007402182,
-0.02552562579512596,
-0.01940935291349888,
-0.00035136984661221504,
-0.008172513917088509,
0.020257171243429184,
0.00785554014146328,
-0.011337706819176674,
0.01944020949304104,
-0.05313313007354736,
0.013439174741506577,
0.026263292878866196,
-0.005915772635489702,
0.009268611669540405,
-0.00608200766146183,
0.004973549395799637,
-0.02600356750190258,
0.016770148649811745,
-0.01683962345123291,
0.011367295868694782,
-0.0023273583501577377,
0.0013603721745312214,
-0.006187306251376867,
-0.005233976058661938,
0.011974960565567017,
0.029442813247442245,
0.012820983305573463,
-0.012483399361371994,
-0.005266004242002964,
0.01499742642045021,
0.07153074443340302,
-0.02565860189497471,
0.014420873485505581,
0.005314718931913376,
0.014515125192701817,
0.006774271372705698,
-0.01598714292049408,
-0.03637396916747093,
-0.00029589422047138214,
-0.010831939056515694,
-0.015296809375286102,
-0.013523247092962265,
0.01460548397153616,
0.012644262053072453,
-0.027133014053106308,
0.010655037127435207,
0.009478136897087097,
0.005303781945258379,
0.00926260743290186,
0.03954601287841797,
-0.007072605192661285,
-0.014999253675341606,
-0.039097074419260025,
0.037676773965358734,
0.014995215460658073,
-0.0019188581500202417,
-0.04138494282960892,
0.0006639352068305016,
-0.007144137751311064,
0.013994788751006126,
0.015667159110307693,
-0.011273732408881187,
0.006340639665722847,
0.02395579218864441,
0.020728059113025665,
0.02360854111611843,
0.006312182638794184,
-0.0033267377875745296,
-0.008675560355186462,
-0.012713943608105183,
-0.014203829690814018,
0.0036931431386619806,
-0.00607223529368639,
0.04227197542786598,
0.008565302938222885,
-0.03209158778190613,
0.001884668366983533,
-0.0180997122079134,
0.013785320334136486,
0.015970440581440926,
0.023955170065164566,
0.0008124102605506778,
0.02908090502023697,
-0.022348618134856224,
-0.0007313077803701162,
0.026085596531629562,
-0.005866172723472118,
0.00666473712772131,
-0.01023467630147934,
0.0005343484226614237,
0.00846774410456419,
-0.0148152532055974,
0.016087111085653305,
-0.0013362111058086157,
0.004920055624097586,
-0.04980989545583725,
0.003481715451925993,
-0.013386345468461514,
-0.017490899190306664,
0.015743402764201164,
0.01538000162690878,
-0.012536079622805119,
0.007959718815982342,
0.01822398230433464,
0.01369866356253624,
0.014210693538188934,
0.019098758697509766,
-0.020067213103175163,
0.023257574066519737,
-0.00202116253785789,
-0.01907718926668167,
0.01705162785947323,
-0.0037531289272010326,
0.014048388227820396,
-0.01688564009964466,
-0.001650218153372407,
0.0058934371918439865,
-0.008857406675815582,
-0.011422593146562576,
0.011253956705331802,
-0.003473687916994095,
-0.011697862297296524,
0.008312848396599293,
0.00005701510235667229,
0.010423826053738594,
0.03163129836320877,
0.019461240619421005,
-0.0024764726404100657,
0.00945213995873928,
0.021946029737591743,
0.007128612138330936,
0.0266417283564806,
0.03804303705692291,
-0.025065742433071136,
-0.027127336710691452,
-0.011213894933462143,
-0.0114311333745718,
-0.01969597116112709,
0.002374147530645132,
0.015431340783834457,
0.0027100646402686834,
0.0067433202639222145,
0.004402804654091597,
-0.0009811678901314735,
0.00957268662750721,
0.012075706385076046,
-0.02031989023089409,
0.01566946506500244,
-0.01272832415997982,
-0.011508472263813019,
0.009616818279027939,
-0.0030378205701708794,
-0.019654085859656334,
-0.0009544491767883301,
-0.000913465628400445,
-0.013471382670104504,
-0.006041840650141239,
0.013873022049665451,
0.022456899285316467,
0.0022885382641106844,
0.008340999484062195,
-0.024746766313910484,
-0.006954933051019907,
0.01832941547036171,
0.020026355981826782,
0.018545715138316154,
-0.014109877869486809,
-0.02442610077559948,
0.014533588662743568,
-0.002206231467425823,
0.0069298166781663895,
-0.00023480132222175598,
0.003918414004147053,
0.030679477378726006,
0.008050772361457348,
0.005379896145313978,
0.015404470264911652,
0.023860197514295578,
0.008269507437944412,
0.01859116367995739,
0.013310506008565426,
0.01583131030201912,
-0.026578444987535477,
-0.006615797057747841,
-0.03766384348273277,
0.02373061329126358,
0.01705678179860115,
0.006922057829797268,
-0.020760925486683846,
-0.016564469784498215,
-0.006980682257562876,
0.018105627968907356,
-0.013039888814091682,
-0.008527997881174088,
0.0009337626397609711,
-0.005851935129612684,
-0.008289136923849583,
-0.023820752277970314,
0.027020258828997612,
0.00488895270973444,
-0.012433246709406376,
-0.03638504818081856,
0.011236250400543213,
0.025688184425234795,
-0.009319275617599487,
-0.011948984116315842,
-0.023320935666561127,
-0.012945489957928658,
-0.015178157016634941,
0.007272876799106598,
-0.016158457845449448,
-0.0001442695502191782,
0.003963771276175976,
-0.008351519703865051,
0.008255865424871445,
-0.033873382955789566,
0.00027821247931569815,
-0.009364331141114235,
0.008776569738984108,
-0.02101954258978367,
0.014651205390691757,
-0.0038117836229503155,
-0.00544164702296257,
0.02026580460369587,
-0.004453578032553196,
-0.016508029773831367,
-0.0037455379497259855,
-0.004666666500270367,
0.0016464421059936285,
-0.017118122428655624,
-0.008203230798244476,
0.0014055791543796659
] | [
0.15721511840820312,
0.028104163706302643,
0.36280542612075806,
0.09116806834936142,
-0.13514459133148193,
0.04913482442498207,
-0.27595439553260803,
0.09871132671833038,
0.001911632250994444,
-0.4086536765098572,
-0.27007827162742615,
0.15782465040683746,
-0.25453391671180725,
0.2009485363960266,
0.10785379260778427,
0.709119975566864,
-0.016318460926413536,
0.4327446520328522,
0.06820578128099442,
-0.6094022393226624,
-0.1307293027639389,
-0.2587951123714447,
0.42818281054496765,
0.10197490453720093,
0.6708745360374451,
0.27501338720321655,
-0.09256187826395035,
0.11671501398086548,
0.7756158113479614,
0.09272028505802155,
-0.10551060736179352,
0.5839139819145203,
-0.13025562465190887,
0.08243980258703232,
-0.08632469922304153,
-0.023971358314156532,
-0.5820239186286926,
-0.09339652955532074,
0.042649850249290466,
-0.07555130869150162,
-0.40122127532958984,
-0.38241705298423767,
-0.30977189540863037,
0.5603218674659729,
-0.41517239809036255,
-0.14557962119579315,
-1.6536824703216553,
0.5709196329116821,
-0.20427508652210236,
-0.11267512291669846,
0.06338717043399811,
0.7446328997612,
0.4619376063346863,
-0.2597506642341614,
0.3418678045272827,
-0.34088385105133057,
-0.6842123866081238,
0.034196995198726654,
0.5162448287010193,
-0.8517044186592102,
0.11167674511671066,
0.25441527366638184,
-0.1155015230178833,
0.14852996170520782,
0.00860241986811161,
0.7569351196289062,
-0.21115432679653168,
-0.43527936935424805,
-0.6125628352165222,
-0.11571547389030457,
0.21050962805747986,
-0.1146942600607872,
-0.14284908771514893,
0.010747668333351612,
0.009636200964450836,
0.4753324091434479,
-0.7557969093322754,
-0.04099442809820175,
0.293048620223999,
0.01228329073637724,
0.0042177364230155945,
0.06880232691764832,
0.4211556017398834,
-0.08542263507843018,
0.5257132649421692,
0.17678514122962952,
-0.426107257604599,
0.39738115668296814,
-0.47453251481056213,
0.2757408022880554,
-0.5252870321273804,
-0.2365458607673645,
0.5526484251022339,
0.33460816740989685,
0.011756346561014652,
0.13647155463695526,
0.01534693967550993,
-0.1475498527288437,
0.19795683026313782,
0.4365404546260834,
-0.5301043391227722,
0.11997944116592407,
-0.06061196327209473,
-0.5001224279403687,
-0.4326635003089905,
0.14752326905727386,
-0.4098305404186249,
-0.21617481112480164,
-0.8616249561309814,
0.30272507667541504,
-0.7408641576766968,
-0.40682485699653625,
-0.5077914595603943,
0.03354840353131294,
0.20611819624900818,
0.08978718519210815,
0.07533514499664307,
-0.11898942291736603,
0.04110400751233101,
0.2854500412940979,
-0.20008647441864014,
0.5747159719467163,
-0.1647840291261673,
0.364050954580307,
0.37763354182243347,
0.39492613077163696,
-0.057893164455890656,
-0.15079346299171448,
-0.23063604533672333,
0.7815433740615845,
0.15621958673000336,
0.6966848969459534,
-0.2761908173561096,
0.3512030243873596,
-0.1608477085828781,
-0.05251258611679077,
0.4084811210632324,
0.11043562740087509,
0.41626882553100586,
0.23226015269756317,
-0.40863102674484253,
0.032225966453552246,
-0.5596310496330261,
-0.46723559498786926,
0.16634254157543182,
-0.613849937915802,
-0.6583620309829712,
-0.0956253707408905,
-0.2957773208618164,
-0.3128369450569153,
-0.09047897160053253,
-0.5328079462051392,
-0.24706842005252838,
-0.12073454260826111,
-0.2808370292186737,
0.42129626870155334,
-0.13772012293338776,
-0.1295677125453949,
0.09065770357847214,
0.15988552570343018,
-0.12107480317354202,
0.40235772728919983,
-0.30448034405708313,
0.2636975646018982,
0.3211883008480072,
-0.0018069194629788399,
0.1175035834312439,
-0.10518965870141983,
-0.06345131993293762,
0.3629937767982483,
-0.2705857455730438,
-0.07706783711910248,
0.11181387305259705,
-0.49562445282936096,
-0.12394440919160843,
-0.3062894642353058,
0.3083046078681946,
-0.2283705770969391,
0.22930246591567993,
-0.46433842182159424,
-0.6923897862434387,
-0.23754560947418213,
-0.16394227743148804,
-0.3761131763458252,
-0.17867690324783325,
0.2555970549583435,
0.3532010018825531,
0.048809394240379333,
0.18906424939632416,
-0.1632654219865799,
-0.24363155663013458,
-0.048794254660606384,
0.5551151037216187,
-0.2911362648010254,
1.4332998991012573,
-0.5514577627182007,
-0.028866609558463097,
1.0402631759643555,
0.15364836156368256,
0.13999657332897186,
-0.23517857491970062,
-0.0320504792034626,
0.16653849184513092,
-0.44553351402282715,
-0.2181698977947235,
0.14442741870880127,
-0.11038491129875183,
-0.1802908480167389,
0.07696002721786499,
-0.5173614025115967,
0.42951422929763794,
-0.42350900173187256,
-0.0763881653547287,
-0.37055397033691406,
0.5374851226806641,
-0.5884284377098083,
0.068914994597435,
-0.03396626189351082,
-0.15952999889850616,
-0.1749507337808609,
0.777285635471344,
-0.4576829969882965,
0.36072856187820435,
0.732461154460907,
-0.4298214912414551,
0.4905321002006531,
0.49349331855773926,
0.1975095421075821,
0.953775942325592,
-0.11091108620166779,
0.33474138379096985,
-0.976831316947937,
0.2753610610961914,
-0.5288037061691284,
-0.14102952182292938,
-0.013664412312209606,
-0.027615582570433617,
0.09978216141462326,
-0.27150964736938477,
-0.11447086930274963,
-0.2541019022464752,
0.5123114585876465,
-1.0252015590667725,
-0.6662104725837708,
0.40270641446113586,
-0.7126469612121582,
-0.322694331407547,
0.3362746238708496,
-0.943662703037262,
-0.06435547769069672,
-0.15425238013267517,
0.2707410156726837,
-0.5187349915504456,
-0.4580303132534027,
0.2994028329849243,
0.41344600915908813,
-0.1949218511581421,
-0.026136724278330803,
-0.07581589370965958,
-0.3133885860443115,
-0.12561893463134766,
0.11182159185409546,
-0.14260569214820862,
0.45422038435935974,
-0.02760409563779831,
-0.273589164018631,
0.05717085674405098,
-0.09127786010503769,
1.1391756534576416,
0.4974670708179474,
0.6469264626502991,
-0.01243724673986435,
-0.7244285345077515,
0.07685975730419159,
-0.14043469727039337,
-0.8132975697517395,
0.13110096752643585,
0.6845740079879761,
0.018301082774996758,
-0.21345312893390656,
0.07314793765544891,
-0.008124368265271187,
0.8883809447288513,
0.20679223537445068,
-0.3907519280910492,
-0.247060626745224,
-0.23341074585914612,
0.052301280200481415,
-0.5059192776679993,
-0.39031240344047546,
-0.19500742852687836,
0.46384331583976746,
-0.41908690333366394,
0.02936520241200924,
-0.0872298926115036,
0.3330284357070923,
0.12521417438983917,
0.5693596601486206,
0.749117374420166,
0.2462855726480484,
-0.1857839673757553,
0.659504771232605,
-0.3162655532360077,
-0.04772627353668213,
0.22833247482776642,
-0.08036527037620544,
-0.39338764548301697,
0.12625037133693695,
-5.826387405395508,
0.5245712995529175,
-0.06067730858922005,
-0.5100544691085815,
0.5228620767593384,
-0.040551137179136276,
1.1611454486846924,
0.12645719945430756,
0.6411390900611877,
-0.016489936038851738,
0.05946020409464836,
0.28630930185317993,
-0.23295468091964722,
0.043373044580221176,
0.05003457888960838,
0.49692198634147644,
0.40706393122673035,
0.34515807032585144,
0.7293922305107117,
0.20961430668830872,
-0.2085217833518982,
-0.43484264612197876,
0.13954895734786987,
0.7080706357955933,
-0.25864312052726746,
0.07994405925273895,
-0.9151411056518555,
0.0019472894491627812,
-0.30320245027542114,
-0.47853848338127136,
0.2791149616241455,
-0.6283957958221436,
-0.3563562333583832,
-0.5057094693183899,
0.3573094606399536,
-0.10690563917160034,
0.1167171448469162,
-0.2239856719970703,
-0.019476138055324554,
-0.7607844471931458,
0.5660333037376404,
0.5803541541099548,
-0.09071607142686844,
-0.18630672991275787,
0.09798658639192581,
-0.2764233350753784,
-0.35722532868385315,
0.13130836188793182,
-0.42632201313972473,
1.1427193880081177,
-0.1867733746767044,
-0.11174369603395462,
0.008788478560745716,
0.46219953894615173,
0.6392841339111328,
0.36108386516571045,
-0.21760712563991547,
0.446667343378067,
-0.35099613666534424,
0.31157827377319336,
-0.10289356857538223,
-0.031082404777407646,
-0.7482343316078186,
-1.0203685760498047,
0.3037319481372833,
-0.05570586770772934,
-0.9599191546440125,
-0.14259600639343262,
0.2985246479511261,
0.0022262767888605595,
-0.3453107476234436,
0.012815355323255062,
-0.10659158229827881,
-0.652873158454895,
0.5561622381210327,
-0.5032685399055481,
0.3322891592979431,
-0.0612996481359005,
0.09655309468507767,
0.025489531457424164,
-0.1904282569885254,
0.48573246598243713,
0.05875370651483536,
0.18149268627166748,
0.34752157330513,
-0.3145204782485962,
-0.20336619019508362,
-0.35426971316337585,
0.0362192839384079,
-0.04903222620487213,
0.3919653594493866,
-0.034460119903087616,
-0.24911503493785858,
0.49777355790138245,
0.1938847154378891,
-0.07344291359186172,
0.104390949010849,
0.8003565669059753,
0.3312086760997772,
-0.31993943452835083,
1.3004447221755981,
-0.25350186228752136,
-0.4031743109226227,
-0.7777810096740723,
-0.17881332337856293,
0.16792744398117065,
-0.4678869843482971,
0.011674933135509491,
0.6151642799377441,
-0.539208710193634,
0.1426156461238861,
-0.05746397003531456,
-0.52208012342453,
0.022450324147939682,
0.871791660785675,
-0.038852203637361526,
-0.2931024730205536,
0.15433301031589508,
0.37944236397743225,
-0.15492196381092072,
0.21462641656398773,
0.328327476978302,
-0.09971052408218384,
0.3990407884120941,
0.15213459730148315,
-0.0670342966914177,
0.4591771364212036,
0.3079199194908142,
-0.5576385259628296,
-0.26401013135910034,
0.672296404838562,
-0.2598344385623932,
-0.4215066730976105,
-0.15277692675590515,
0.17964868247509003,
-0.4654237627983093,
-0.695024311542511,
0.20958352088928223,
0.5725910663604736,
0.11826412379741669,
0.14314375817775726,
-0.2705603241920471,
-0.07132192701101303,
0.2703503370285034,
0.7635502219200134,
-0.05466336011886597,
-0.16295887529850006,
0.4114077389240265,
-0.187528595328331,
0.07028163224458694,
0.1514403223991394,
-0.046604741364717484,
-0.08402622491121292,
-0.3637971878051758,
0.12262240052223206,
0.18694175779819489,
0.5512822270393372,
0.1290539801120758,
0.33130019903182983,
-0.5905090570449829,
0.403841108083725,
0.2994328439235687,
-0.8839519619941711,
0.3463112413883209,
-0.4269477427005768,
-0.506907045841217,
-0.2515001893043518,
-0.5552630424499512,
-0.12671999633312225,
0.1236344426870346,
-0.3136187195777893,
-0.07901604473590851,
0.17693178355693817,
-0.11779024451971054,
-0.30321112275123596,
-0.0886603593826294,
-0.456307053565979,
0.038005176931619644,
0.37256962060928345,
-0.013826465234160423,
-0.009329578839242458,
-0.17582765221595764,
-0.02662486396729946,
0.20517301559448242,
0.447767972946167,
0.5067006349563599,
-0.25436264276504517,
0.19430138170719147,
-0.010350442491471767,
-0.353944331407547,
0.11300455033779144,
-0.11931657791137695,
0.17465408146381378,
0.053160544484853745,
0.12456081062555313,
0.1970447599887848,
0.20556271076202393,
0.45072728395462036,
-0.12982410192489624,
-0.5041496753692627,
0.021993190050125122,
0.15710987150669098,
-0.44181832671165466,
0.6495558619499207,
0.33303478360176086,
0.152226984500885,
0.28796595335006714,
0.24350707232952118,
-0.0009751830948516726,
-0.0761803686618805,
-0.24624671041965485,
-0.6794768571853638,
0.11481835693120956,
0.41136354207992554,
-0.09921370446681976,
-0.156442791223526,
-0.14160728454589844,
-0.7868599891662598,
-0.5339270234107971,
0.3749449849128723,
0.07400081306695938,
-0.2332671880722046,
0.43418368697166443,
0.0035680721048265696,
-0.5628728866577148,
0.053193312138319016,
0.5988773703575134,
-0.46133071184158325,
0.21767865121364594,
0.04160355404019356,
-0.2983691990375519,
0.1358647346496582,
0.23515069484710693,
-0.012781728990375996,
-0.47877538204193115,
0.10424942523241043,
-0.42836424708366394,
0.01833580620586872,
0.337157666683197,
0.5257233381271362,
-0.02687077969312668,
0.4177851378917694,
-0.41586440801620483,
-0.6529534459114075,
0.3397526443004608,
0.5831166505813599,
0.47148415446281433,
-0.32588526606559753,
-0.2678430378437042,
0.1168828159570694,
0.8547506332397461,
-0.3600924015045166,
0.16854411363601685,
0.05427674949169159,
0.8484211564064026,
0.024887925013899803,
-0.20047257840633392,
-0.19043585658073425,
-0.26175954937934875,
0.4474858045578003,
-0.14203926920890808,
-0.21400116384029388,
0.12143179029226303,
-0.09441480040550232,
0.3062533438205719,
-0.25086772441864014,
-0.35411760210990906,
-0.9128573536872864,
0.3266046345233917,
-0.2766009569168091,
0.18937437236309052,
0.20133112370967865,
0.8216613531112671,
0.2069491744041443,
-0.43102678656578064,
0.09215783327817917,
-0.18889470398426056,
-0.06644867360591888,
-0.11386141180992126,
0.26994091272354126,
-0.6549197435379028,
-0.5650806427001953,
0.2732336223125458,
-0.13531439006328583,
0.7620087265968323,
-0.7990622520446777,
-0.47865644097328186,
-0.491538941860199,
0.19378456473350525,
-0.25048109889030457,
-0.39741629362106323,
0.16913551092147827,
-0.6641127467155457,
-0.46743544936180115,
-0.13139159977436066,
0.5252313017845154,
0.4976770579814911,
-0.07570242881774902,
0.1840425431728363,
0.4055681824684143,
-0.3922967314720154,
0.5466023087501526,
0.20690280199050903,
-0.3573916554450989,
0.19712534546852112,
0.29344868659973145,
0.13821172714233398,
-0.17658483982086182,
-0.3040866553783417,
-0.3441162705421448,
0.09071808308362961,
-0.2537190914154053,
0.44268548488616943,
-0.19534514844417572,
-0.46343836188316345,
-0.08433768153190613,
0.07227469235658646,
-0.44343364238739014,
0.3573935627937317,
0.5009437203407288,
0.2339688390493393,
0.7869703769683838,
0.541484534740448,
-0.011781750246882439,
-0.237032949924469,
0.5376911759376526,
0.3243691325187683,
-0.09573090821504593,
0.10794312506914139,
0.6450340747833252,
0.35584181547164917,
-0.08735652267932892,
0.42344924807548523,
0.2950313985347748,
0.17766796052455902,
0.31324082612991333,
0.25929540395736694,
-0.35560542345046997,
-0.03806744143366814,
0.06264310330152512,
0.12818893790245056,
0.5047948360443115,
0.1392994076013565,
-0.37817516922950745,
0.044246606528759,
0.49519288539886475,
0.1432829648256302,
0.27272361516952515,
-0.07103077322244644,
0.42437317967414856,
0.1403753161430359,
-0.46945416927337646,
-0.5136042237281799,
0.10174925625324249,
-0.5847705006599426,
0.5517129302024841,
0.28317227959632874,
-0.2750900387763977,
-0.5077598690986633,
0.14227929711341858,
-0.7601820230484009,
0.012833632528781891,
0.11252587288618088,
0.6622160077095032,
-0.5885387659072876,
-0.011607307940721512,
0.14326176047325134,
-0.08675263822078705,
0.3789514899253845,
-0.33849722146987915,
-0.31099697947502136,
0.056563399732112885,
-0.13065838813781738,
0.09692393243312836,
-0.11832094937562943,
-0.7203928828239441,
0.2680302858352661,
0.14835217595100403,
-0.03731483221054077,
0.6084237694740295,
-0.1517588347196579,
0.28031718730926514,
-0.19966742396354675,
-0.7631545066833496,
-0.13530954718589783,
-0.23292164504528046,
-0.4917756915092468,
-0.07710081338882446,
0.19785171747207642,
0.15945014357566833,
0.02136029489338398,
-0.5274954438209534,
0.7536801099777222,
-0.11675256490707397,
0.049660149961709976,
-0.009959503076970577,
-0.046980418264865875,
0.42718639969825745,
0.3141058385372162,
0.25244081020355225,
-0.3165731132030487,
0.41798481345176697,
0.008131217211484909,
0.33088400959968567,
-0.16910278797149658,
0.40281590819358826,
-0.4469757378101349,
0.03416307270526886,
-0.03315771371126175,
-0.30147719383239746,
0.9137595295906067,
0.6214631199836731,
-0.3660002648830414,
0.3476792871952057,
0.10089379549026489,
0.2248860001564026,
0.6419381499290466,
0.01970580220222473,
-0.20594879984855652,
-0.3926048278808594,
-0.21440833806991577,
-0.5234819650650024,
0.47921720147132874,
0.04771200194954872,
0.23113316297531128,
-0.021677933633327484,
0.36901459097862244,
0.6347851753234863,
-0.5710249543190002,
0.5342556238174438,
-0.10763978958129883,
-0.8172321915626526,
-0.6059162020683289,
0.4555719494819641,
-0.5920894742012024,
0.4705412685871124,
-0.670853316783905,
0.39695486426353455,
0.4487621486186981,
-0.23534837365150452,
0.13171258568763733,
-0.13923318684101105,
0.047723401337862015,
-0.27422019839286804,
0.13552314043045044,
0.2833499312400818,
-0.19442735612392426,
-0.7196506857872009,
-0.9535905718803406,
0.11192586272954941,
-0.10147653520107269,
-1.2110865116119385,
-0.12647497653961182,
0.27316632866859436,
-0.21722038090229034,
-0.14091920852661133,
0.02446393482387066,
-0.14921435713768005,
-0.5886437296867371,
-0.17833936214447021
] |
Staphylococcus aureus is a human commensal that can also cause systemic infections. This transition requires evasion of the immune response and the ability to exploit different niches within the host. However, the disease mechanisms and the dominant immune mediators against infection are poorly understood. Previously it has been shown that the infecting S. aureus population goes through a population bottleneck, from which very few bacteria escape to establish the abscesses that are characteristic of many infections. Here we examine the host factors underlying the population bottleneck and subsequent clonal expansion in S. aureus infection models, to identify underpinning principles of infection. The bottleneck is a common feature between models and is independent of S. aureus strain. Interestingly, the high doses of S. aureus required for the widely used "survival" model results in a reduced population bottleneck, suggesting that host defences have been simply overloaded. This brings into question the applicability of the survival model. Depletion of immune mediators revealed key breakpoints and the dynamics of systemic infection. Loss of macrophages, including the liver Kupffer cells, led to increased sensitivity to infection as expected but also loss of the population bottleneck and the spread to other organs still occurred. Conversely, neutrophil depletion led to greater susceptibility to disease but with a concomitant maintenance of the bottleneck and lack of systemic spread. We also used a novel microscopy approach to examine abscess architecture and distribution within organs. From these observations we developed a conceptual model for S. aureus disease from initial infection to mature abscess. This work highlights the need to understand the complexities of the infectious process to be able to assign functions for host and bacterial components, and why S. aureus disease requires a seemingly high infectious dose and how interventions such as a vaccine may be more rationally developed. | [
-0.013987069949507713,
0.011201889254152775,
-0.012109831906855106,
0.012205405160784721,
0.02245742455124855,
0.0007304648170247674,
0.0100795803591609,
-0.0029612563084810972,
-0.014234096743166447,
0.0015785892028361559,
-0.002497186418622732,
0.005712980404496193,
-0.012630835175514221,
0.02204529568552971,
0.004485496785491705,
0.014685165137052536,
-0.020523682236671448,
0.005164268892258406,
0.00450334046036005,
-0.0030658345203846693,
0.020886586979031563,
0.0041885823011398315,
0.010100649669766426,
-0.008309680968523026,
-0.014618615619838238,
-0.004932583309710026,
-0.012964501045644283,
-0.000511769438162446,
-0.012068270705640316,
0.010098244994878769,
-0.002784651704132557,
0.036217641085386276,
0.0009747149888426065,
0.0042353468015789986,
0.012743310071527958,
0.0017821895889937878,
-0.0039364793337881565,
0.023292455822229385,
0.01112065464258194,
-0.003860886674374342,
0.0015991099644452333,
-0.009229778312146664,
0.003116853069514036,
-0.014443371444940567,
-0.007292961701750755,
0.0028651689644902945,
0.001282492303289473,
-0.023280596360564232,
-0.009992293082177639,
0.0020559807308018208,
0.004497521091252565,
-0.008999167010188103,
-0.011086879298090935,
-0.015286536887288094,
-0.00652312720194459,
0.010894893668591976,
0.019976917654275894,
0.01728506200015545,
-0.02087607979774475,
-0.010290888138115406,
-0.002028822433203459,
0.0042199124582111835,
-0.018796265125274658,
-0.01797299087047577,
0.04252912849187851,
-0.06676790118217468,
0.019694779068231583,
0.0012883845483884215,
-0.013323177583515644,
0.012700160965323448,
-0.017369361594319344,
0.0023375735618174076,
-0.007028611376881599,
0.009435340762138367,
-0.02375207096338272,
-0.010252882726490498,
-0.0035021041985601187,
0.009074116125702858,
0.0015421868301928043,
0.028150159865617752,
0.00509149394929409,
-0.004262271802872419,
0.014303847216069698,
0.020520012825727463,
-0.002408972242847085,
0.012189315631985664,
-0.004370592534542084,
-0.0086127370595932,
0.0012223310768604279,
-0.0017951303161680698,
0.007462070323526859,
-0.023228302597999573,
-0.022782951593399048,
0.015576671808958054,
0.008499737828969955,
-0.03146672248840332,
-0.031631000339984894,
-0.02112557366490364,
0.00842764787375927,
-0.00872507132589817,
-0.01756276562809944,
-0.0010496925096958876,
0.016702305525541306,
0.00239559356123209,
0.01570824161171913,
0.005005064886063337,
0.0024698302149772644,
0.017660247161984444,
0.022923918440937996,
0.015817249193787575,
-0.014751803129911423,
0.004838551394641399,
-0.019585801288485527,
0.03265220671892166,
0.03228462487459183,
0.0007110860897228122,
-0.00028375908732414246,
0.01891523413360119,
0.010588250122964382,
0.010737940669059753,
0.009498914703726768,
-0.024197982624173164,
-0.005281674209982157,
0.02002001367509365,
0.005480028223246336,
0.03699386864900589,
-0.010464044287800789,
-0.014787965454161167,
0.016621854156255722,
0.002331297844648361,
-0.005078170448541641,
-0.016104403883218765,
0.022102804854512215,
0.014736155048012733,
-0.0038508872967213392,
-0.005269201006740332,
-0.01680813729763031,
-0.005816303193569183,
0.00002114078961312771,
-0.019610099494457245,
-0.005657186731696129,
0.011158929206430912,
0.002537719439715147,
0.014102836139500141,
0.030715499073266983,
-0.006378565914928913,
0.022054065018892288,
0.009173541329801083,
0.0096353180706501,
0.009561782702803612,
0.015681162476539612,
-0.020002026110887527,
-0.026774317026138306,
-0.004028691444545984,
0.005299950949847698,
0.0016284040175378323,
-0.0005040185060352087,
-0.02622312866151333,
0.012512161396443844,
0.01060434989631176,
-0.011894007213413715,
0.0030156283173710108,
0.009713597595691681,
0.00773647241294384,
0.014640050008893013,
-0.011768008582293987,
0.009286327287554741,
-0.0040809777565300465,
0.003459090366959572,
0.007240440230816603,
-0.001118273357860744,
-0.006143767852336168,
-0.007648030761629343,
0.014827298000454903,
0.010876118205487728,
0.001363315968774259,
0.013131668791174889,
0.009178959764540195,
-0.00793888233602047,
0.06657907366752625,
0.0012726455461233854,
-0.0037074533756822348,
-0.01334872655570507,
-0.005840391851961613,
0.011343743652105331,
0.009565388783812523,
0.04476412385702133,
-0.006708288565278053,
-0.019035357981920242,
-0.020072169601917267,
0.011927985586225986,
-0.03438493609428406,
0.013687588274478912,
-0.013976688496768475,
-0.008624819107353687,
0.003944630268961191,
0.007533814292401075,
-0.007726726122200489,
0.00449921190738678,
0.010845604352653027,
-0.00007969001308083534,
0.0003405660390853882,
0.03448869287967682,
0.03511394187808037,
-0.01700446754693985,
0.006432532798498869,
0.009770499542355537,
0.008196340873837471,
-0.007213340140879154,
-0.015088113024830818,
0.01579592190682888,
-0.008877813816070557,
0.010084755718708038,
-0.010707041248679161,
0.004866231232881546,
0.010675881057977676,
0.01075828354805708,
-0.028826352208852768,
-0.02248385176062584,
-0.013137307949364185,
-0.004754952155053616,
-0.006569579243659973,
-0.005711003672331572,
0.0203065387904644,
0.019739992916584015,
0.005704578943550587,
-0.001808884902857244,
0.010774163529276848,
-0.019463691860437393,
-0.0030461526475846767,
-0.006339724175632,
-0.03303028643131256,
-0.00891156867146492,
0.0012337572406977415,
0.02768545225262642,
0.0162470992654562,
0.008017167448997498,
-0.0036409671884030104,
0.011794017627835274,
-0.0008378574275411665,
0.00016010552644729614,
0.0013199446257203817,
-0.00004564458504319191,
0.02012680098414421,
-0.014250434935092926,
-0.007114015053957701,
0.012812864035367966,
0.0006559295579791069,
0.02889373153448105,
-0.02032071352005005,
0.008064981549978256,
0.023566294461488724,
0.01732553355395794,
0.010654796846210957,
-0.0013234822545200586,
0.002085617510601878,
-0.009063482284545898,
-0.01717333495616913,
0.026094675064086914,
-0.012451750226318836,
0.007690627593547106,
0.002513854531571269,
0.002483844757080078,
-0.008965037763118744,
0.01839221641421318,
0.03739459812641144,
-0.02583923749625683,
0.00756108621135354,
0.015308061614632607,
-0.00008413835894316435,
0.006620058789849281,
-0.0037578113842755556,
0.009295116178691387,
-0.08180985599756241,
-0.021283796057105064,
0.007505094166845083,
0.0007811230607330799,
0.01345090102404356,
0.022277459502220154,
-0.013973992317914963,
0.003014319809153676,
0.000751130748540163,
0.03589571267366409,
0.01804526522755623,
0.01779678463935852,
-0.005133781582117081,
-0.01212460920214653,
-0.017413044348359108,
-0.008452434092760086,
0.0039886413142085075,
0.006738606840372086,
-0.010656684637069702,
-0.004827815108001232,
-0.01703207567334175,
-0.0023874519392848015,
-0.014030445367097855,
-0.003238232107833028,
0.018948610872030258,
-0.012133372947573662,
0.025210481137037277,
-0.0006516212597489357,
0.02258283644914627,
0.019426897168159485,
-0.002212118823081255,
-0.01734599843621254,
-0.006075634621083736,
0.0005151750519871712,
0.005579064600169659,
-0.006853063590824604,
-0.010869032703340054,
-0.010122131556272507,
-0.009027465246617794,
0.002181488089263439,
-0.005480664316564798,
0.021301710978150368,
-0.00943989772349596,
0.015174111351370811,
0.018769223242998123,
0.025961682200431824,
0.014767569489777088,
-0.005132589489221573,
0.008455103263258934,
-0.007945368997752666,
0.008941370993852615,
-0.003996022045612335,
0.017484217882156372,
0.008046463131904602,
-0.004660505801439285,
-0.011115227825939655,
-0.03420992195606232,
0.02642742730677128,
-0.013742011040449142,
-0.008963745087385178,
0.012806215323507786,
0.0010611566249281168,
0.0029532844200730324,
0.01983712986111641,
0.012398703023791313,
0.02483522519469261,
0.01931299827992916,
0.010114902630448341,
-0.010755615308880806,
0.003903025295585394,
-0.003968864679336548,
-0.008629435673356056,
0.018953822553157806,
-0.015711002051830292,
0.014793426729738712,
-0.006314537487924099,
-0.009321004152297974,
-0.00391866359859705,
-0.022869907319545746,
-0.020261196419596672,
-0.020952165126800537,
-0.007125735282897949,
-0.007173390127718449,
0.001957360189408064,
-0.02313145250082016,
-0.03727886080741882,
0.007207286078482866,
0.010129876434803009,
0.0067131975665688515,
-0.014661568216979504,
0.042206041514873505,
-0.02040761709213257,
0.0031424309127032757,
0.013759777881205082,
-0.016972018405795097,
0.01174179371446371,
-0.009477837011218071,
-0.02698146365582943,
0.0006918376311659813,
0.007755124941468239,
0.0020559988915920258,
0.010294873267412186,
0.003056344809010625,
-0.0026931024622172117,
0.00594492070376873,
0.016514580696821213,
0.016736682504415512,
0.045120783150196075,
0.0003812409704551101,
-0.0008502842974849045,
0.00035908143036067486,
-0.0006108824163675308,
-0.0018545823404565454,
0.024875003844499588,
0.014563498087227345,
0.009858532808721066,
0.006824677810072899,
0.003303337609395385,
0.07213000953197479,
-0.029215866699814796,
-0.0016301459399983287,
0.00039818347431719303,
0.00024117855355143547,
-0.014771683141589165,
-0.03991200774908066,
0.010326765477657318,
-0.0010413345880806446,
-0.001885170117020607,
0.013461184687912464,
-0.0026461188681423664,
0.011126413941383362,
-0.019184894859790802,
-0.023205924779176712,
-0.010579986497759819,
-0.02708088420331478,
-0.02341447025537491,
-0.003988986369222403,
0.0071130190044641495,
-0.002761149313300848,
0.0019381650490686297,
-0.02551949769258499,
0.035310059785842896,
-0.015349894762039185,
-0.023881729692220688,
-0.004606223665177822,
-0.013426953926682472,
-0.01787414960563183,
0.007576540112495422,
0.0012605406809598207,
0.03301513195037842,
-0.00959828682243824,
0.002695194911211729,
0.03049934282898903,
-0.02362491562962532,
0.0075550018809735775,
0.01823069155216217,
0.0225029569119215,
-0.006838120520114899,
-0.006485845893621445,
-0.01637854427099228,
-0.00048457877710461617,
0.026433583348989487,
-0.03847838565707207,
0.025093840435147285,
0.012006044387817383,
-0.006264829076826572,
-0.0019457433372735977,
-0.009233181364834309,
-0.009724387899041176,
0.008262007497251034,
0.01193214487284422,
-0.0008854387560859323,
0.039725400507450104,
0.028447266668081284,
0.027877118438482285,
-0.0015347579028457403,
-0.009467396885156631,
-0.012778835371136665,
-0.0026799067854881287,
0.0011625844053924084,
-0.0013727605110034347,
-0.004956853576004505,
0.011672284454107285,
-0.0058900280855596066,
-0.002236003987491131,
0.008046846836805344,
-0.018399298191070557,
0.013404352590441704,
0.02112480252981186,
-0.024389158934354782,
-0.025424297899007797,
-0.006864611059427261,
-0.015825418755412102,
0.006994298659265041,
-0.006268535275012255,
0.0154339000582695,
0.00811090786010027,
0.020172834396362305,
0.01843295618891716,
0.0004572714096866548,
-0.008506123907864094,
0.007937062531709671,
0.009181485511362553,
0.00013024150393903255,
-0.02136865258216858,
-0.07457228004932404,
0.011488432995975018,
-0.01479305513203144,
-0.004399411380290985,
0.016378622502088547,
0.01581903174519539,
0.007192547898739576,
-0.017935818061232567,
0.01743229851126671,
-0.008196844719350338,
-0.056911371648311615,
0.002633820055052638,
-0.005721265450119972,
0.010582253336906433,
0.011998597532510757,
0.00664079375565052,
0.003826088272035122,
-0.004930530674755573,
-0.03376588970422745,
0.025602078065276146,
0.01431303657591343,
0.006758622359484434,
-0.03403491526842117,
0.010292518883943558,
0.0012455955147743225,
-0.08095166087150574,
-0.00992001686245203,
-0.003322679316624999,
-0.022266630083322525,
0.008201425895094872,
0.01124495081603527,
-0.012384121306240559,
-0.0016348430654034019,
-0.007232059724628925,
-0.01655901037156582,
0.001475994591601193,
-0.010463845916092396,
-0.025149114429950714,
-0.007737237960100174,
0.009581119753420353,
-0.008418206125497818,
0.024286050349473953,
-0.0063090152107179165,
-0.03465381637215614,
0.028480159118771553,
0.00404726155102253,
0.010433148592710495,
-0.00857334490865469,
-0.0010733235394582152,
-0.01707804948091507,
-0.01454041339457035,
-0.014780138619244099,
0.008882507681846619,
-0.007722238544374704,
0.012615498155355453,
-0.010484865866601467,
0.009165092371404171,
-0.005000940524041653,
-0.02398686856031418,
-0.008160433731973171,
-0.0019194770138710737,
0.03135304152965546,
0.013199223205447197,
-0.008273354731500149,
-0.007092158310115337,
-0.005481559317559004,
0.00006966013461351395,
0.021326078101992607,
0.005145518109202385,
-0.010150399059057236,
-0.012103012762963772,
0.00680107856169343,
-0.005834471434354782,
0.009248554706573486,
0.000476200133562088,
0.009846478700637817,
0.013743018731474876,
0.008439719676971436,
-0.005004533566534519,
0.0033988829236477613,
0.0038854447193443775,
-0.00785356480628252,
0.003565459046512842,
-0.0010154624469578266,
0.004322777967900038,
-0.007917817682027817,
-0.023338917642831802,
0.017421718686819077,
0.07152582705020905,
-0.020356055349111557,
-0.0006809881888329983,
0.026454664766788483,
0.011804557405412197,
0.0009850943461060524,
0.0003476790152490139,
0.007236646022647619,
-0.010080386884510517,
-0.00670948252081871,
0.0067628053948283195,
0.001139434170909226,
0.004388133995234966,
0.00868632085621357,
0.029667887836694717,
-0.0053613390773534775,
-0.023584220558404922,
-0.04194663465023041,
-0.015211327001452446,
-0.014551936648786068,
-0.011821054853498936,
-0.008356504142284393,
-0.051163967698812485,
0.013994177803397179,
0.010400660336017609,
0.013178407214581966,
-0.010160420089960098,
0.03702231124043465,
-0.01610695943236351,
0.01923174411058426,
-0.020876551046967506,
-0.00232236017473042,
0.005840302910655737,
-0.012289351783692837,
0.018138371407985687,
-0.022210586816072464,
0.00881243497133255,
-0.001723351189866662,
-0.011244110763072968,
0.020764149725437164,
0.01985795795917511,
0.007274305447936058,
0.004797224886715412,
-0.009109500795602798,
0.028528325259685516,
-0.008302951231598854,
0.008129939436912537,
-0.00611400231719017,
0.021791715174913406,
0.027877669781446457,
-0.011971518397331238,
0.012927352450788021,
0.02645081654191017,
0.007006165571510792,
-0.003671166719868779,
0.002625578548759222,
-0.011137568391859531,
0.009810693562030792,
0.004533430561423302,
-0.009487093426287174,
-0.01530371978878975,
-0.0017989421030506492,
-0.01585204526782036,
-0.022501319646835327,
-0.009731266647577286,
-0.0013326219050213695,
-0.0007925115060061216,
-0.019229907542467117,
-0.007105857599526644,
0.01615271344780922,
0.0013007406378164887,
0.012992947362363338,
0.004900191444903612,
-0.010346833616495132,
0.003732031676918268,
0.005777061451226473,
0.0017058816738426685,
0.010828988626599312,
0.010054990649223328,
0.005437271669507027,
0.006138522177934647,
-0.025790169835090637,
0.0033320561051368713,
-0.018325623124837875,
-0.010411370545625687,
0.009010699577629566,
-0.012839050963521004,
-0.007226146757602692,
-0.007772755343466997,
0.005334319081157446,
0.009164457209408283,
0.01055075228214264,
0.0047218771651387215,
0.03710200637578964,
0.009096333757042885,
0.034996502101421356,
-0.023701857775449753,
0.009755948558449745,
0.007794871460646391,
0.012600496411323547,
0.02347305417060852,
0.01996368169784546,
-0.014268556609749794,
-0.0027840682305395603,
-0.014981163665652275,
-0.004404187668114901,
-0.024218544363975525,
0.02200954407453537,
-0.00909118540585041,
-0.005662446841597557,
0.010501467622816563,
0.006574550643563271,
-0.02243966981768608,
-0.004257825203239918,
-0.018574435263872147,
0.003297284943982959,
-0.011287553235888481,
0.009823223575949669,
0.005505220498889685,
-0.012829750776290894,
-0.00978945754468441,
0.007035841234028339,
-0.04129089415073395,
0.004739340394735336,
0.005479041021317244,
-0.01416431088000536,
-0.004458251409232616,
-0.02178305946290493,
0.010008749552071095,
0.008542625233530998,
0.006597182247787714,
0.016807373613119125,
0.01077094953507185,
-0.025059286504983902,
-0.00046854629181325436,
-0.009344929829239845,
0.011369607411324978,
0.01636642962694168,
0.004447479732334614,
-0.0009052217938005924,
0.016114436089992523,
-0.03219860792160034,
0.0004884299705736339,
0.0037924768403172493,
0.008641312830150127,
-0.0006588771939277649,
-0.011155997402966022,
0.016017939895391464,
0.01997155323624611,
0.000059983693063259125,
0.004511811770498753,
0.006127119064331055,
0.013663481920957565,
-0.00885172002017498,
-0.009774553589522839,
0.01820952445268631,
0.011001499369740486,
0.0023904372937977314,
0.0003150440752506256,
-0.014657088555395603,
0.002862566849216819,
-0.012315118685364723,
0.007889531552791595,
-0.011277805082499981,
0.03810996934771538,
0.0030087162740528584,
-0.0036563039757311344,
0.014340152963995934,
-0.009635544382035732,
-0.006480842363089323,
0.020249102264642715,
-0.008746703155338764,
0.020450398325920105,
-0.012677382677793503,
-0.007380458526313305,
-0.014109190553426743,
-0.00889594666659832,
0.004391930066049099,
-0.012835007160902023,
0.0036265987437218428,
-0.018209118396043777,
-0.011125733144581318,
0.010546939447522163,
-0.004836137406527996,
0.009840032085776329,
0.010481289587914944,
-0.022880794480443,
0.0003927452489733696,
0.005826802924275398,
-0.026647046208381653,
-0.008073936216533184,
-0.0029820683412253857,
0.01200345903635025,
0.002935898257419467,
0.017140164971351624,
-0.004330063238739967,
-0.011854894459247589,
-0.005018186289817095,
-0.004806919023394585,
-0.0072178915143013,
-0.010023098438978195,
-0.013672138564288616
] | [
0.5492995381355286,
0.3545963168144226,
-0.20243313908576965,
-0.18344725668430328,
-0.3210870623588562,
0.1959742158651352,
0.7740871906280518,
0.07384377717971802,
0.1473158746957779,
-0.7196425199508667,
-0.08577101677656174,
0.18846248090267181,
-0.7365138530731201,
0.48368409276008606,
-0.1318887323141098,
0.19811901450157166,
0.6015496850013733,
0.36565205454826355,
-0.2448846995830536,
-0.031090566888451576,
-0.7570731043815613,
-0.19434337317943573,
0.3282006084918976,
-0.20231761038303375,
0.24661190807819366,
-0.30197304487228394,
0.21028923988342285,
0.1550712287425995,
0.12921501696109772,
-0.34365949034690857,
0.4843041002750397,
0.3609241843223572,
-0.1238834336400032,
-0.13741150498390198,
-0.4192434251308441,
-0.3005169928073883,
0.11785827577114105,
-0.4032086133956909,
0.05301128700375557,
-0.46634796261787415,
-0.3233301639556885,
0.08896195888519287,
0.19876430928707123,
0.20677492022514343,
-0.18664970993995667,
-0.012411783449351788,
-0.7632685303688049,
0.36314791440963745,
-0.30079859495162964,
0.08351904898881912,
0.06289534270763397,
-0.20527853071689606,
-0.14986881613731384,
0.3175833821296692,
-0.244320809841156,
0.1404731273651123,
-1.0352476835250854,
0.07401368021965027,
0.17160266637802124,
-0.8027999997138977,
0.08133148401975632,
-0.18060815334320068,
-0.3556438982486725,
0.3437863290309906,
-0.11286967247724533,
0.53254634141922,
0.15036462247371674,
0.06424681842327118,
-0.17519201338291168,
-0.041307661682367325,
-0.26189762353897095,
-0.8883318901062012,
-0.042793143540620804,
0.29906895756721497,
-0.08066726475954056,
-0.1392718106508255,
-0.47327905893325806,
-0.547688901424408,
0.2020660787820816,
-0.4813236594200134,
0.15274807810783386,
0.250346839427948,
0.26917633414268494,
0.06962400674819946,
0.6857402920722961,
0.1075734943151474,
-0.18449775874614716,
0.5265769362449646,
-0.5001872777938843,
0.6225630044937134,
-0.025091607123613358,
0.2798469364643097,
0.6088017225265503,
-0.2473720908164978,
0.08078853040933609,
0.27496132254600525,
0.34234434366226196,
0.12161726504564285,
0.3727805018424988,
-0.09060095250606537,
-0.8438414931297302,
-0.26075756549835205,
-0.3793898820877075,
-0.4350852370262146,
0.01605091616511345,
0.22448286414146423,
-0.045007530599832535,
0.10828973352909088,
0.2034306526184082,
0.370366632938385,
-0.41736510396003723,
0.2987576127052307,
-0.1044466570019722,
0.08908268064260483,
-0.12930111587047577,
-0.24451002478599548,
0.14553898572921753,
-0.5608421564102173,
-0.16127271950244904,
-0.37580645084381104,
0.06682179868221283,
0.376247376203537,
-0.21539835631847382,
0.11464443802833557,
-0.25270235538482666,
-0.20723484456539154,
0.16210982203483582,
0.35992419719696045,
-0.2744709849357605,
0.5919386148452759,
0.5596022605895996,
0.8408224582672119,
-0.29801297187805176,
0.0405220203101635,
0.13815061748027802,
-0.3197411298751831,
-0.023511597886681557,
0.20770704746246338,
0.03715137764811516,
0.16217532753944397,
-0.4571627378463745,
-0.18042971193790436,
-0.6001434922218323,
0.38655298948287964,
-0.5928575992584229,
-0.43327343463897705,
0.33532997965812683,
0.2619229555130005,
-0.11819605529308319,
-0.019145110622048378,
0.3793322443962097,
0.3424489498138428,
-0.8927343487739563,
0.05759081244468689,
0.005115581210702658,
0.36213234066963196,
0.1834767460823059,
-0.347614586353302,
-0.01892639882862568,
0.31870678067207336,
0.10527937114238739,
0.018149951472878456,
-0.3111664652824402,
0.07699459791183472,
0.41502413153648376,
-0.3488081991672516,
-0.22366277873516083,
0.19575715065002441,
-0.07534699141979218,
0.13150466978549957,
-0.4305742681026459,
0.1217590868473053,
-0.28517240285873413,
-0.4894813299179077,
0.08368942141532898,
0.541998565196991,
0.39326682686805725,
0.01583436317741871,
0.2774448096752167,
0.2193611115217209,
-0.46749258041381836,
0.39176592230796814,
-0.3882816731929779,
0.13246287405490875,
0.509178102016449,
0.10733754187822342,
0.5799345970153809,
-0.06533610820770264,
0.02277514897286892,
-0.25906839966773987,
-0.8094517588615417,
-0.7256380319595337,
-0.01180481631308794,
-0.3353145122528076,
1.2084388732910156,
-0.43491342663764954,
-0.5880391001701355,
0.8496072888374329,
0.0017753897700458765,
-0.06705926358699799,
-0.041550107300281525,
0.058905161917209625,
0.0849141851067543,
-0.27793875336647034,
-1.121414065361023,
0.22227005660533905,
-0.004059677943587303,
-0.2936682403087616,
0.817103922367096,
0.014039101079106331,
0.7657459378242493,
-0.5937934517860413,
-0.12887310981750488,
-0.550794243812561,
0.29330864548683167,
0.06985893845558167,
-0.12937164306640625,
-0.18162301182746887,
-0.058288536965847015,
-0.35857680439949036,
0.6687753796577454,
-0.6922777891159058,
0.501123309135437,
0.5012423992156982,
-0.3586084544658661,
0.28874829411506653,
0.44822144508361816,
-0.014104276895523071,
0.8594518899917603,
-0.5336670875549316,
0.23353087902069092,
0.1138543114066124,
0.4588659107685089,
-0.5790101289749146,
-0.031561948359012604,
0.7462968826293945,
0.4179518520832062,
-0.4930460751056671,
-0.23547275364398956,
0.04907988756895065,
0.31179314851760864,
0.6074537038803101,
-0.28466281294822693,
0.3828918933868408,
-0.0804382935166359,
-0.3449379503726959,
-0.19021615386009216,
0.4240197241306305,
-1.2891842126846313,
-0.08917491137981415,
-0.046612825244665146,
0.6518357396125793,
0.21418464183807373,
-0.35990822315216064,
0.0869775041937828,
-0.022556273266673088,
-0.30624112486839294,
-0.3024066686630249,
-0.005506988149136305,
-0.274156391620636,
-0.7794477939605713,
0.1495944857597351,
-0.2931070625782013,
0.49952641129493713,
-0.11040852218866348,
-0.3675231337547302,
-0.861574113368988,
-0.4163838326931,
0.5031517744064331,
0.4643060564994812,
0.5752364993095398,
0.09429670870304108,
-0.9491215944290161,
-0.12590348720550537,
-0.20824070274829865,
0.20157647132873535,
0.2983611524105072,
0.5417861938476562,
-0.10845596343278885,
-0.27916085720062256,
-0.5793699026107788,
0.4199444055557251,
0.3856244385242462,
-0.36216098070144653,
-0.38377881050109863,
-0.5795333981513977,
0.15116004645824432,
-0.3191309869289398,
-1.0513345003128052,
-0.06687698513269424,
-0.05676226317882538,
0.5066828727722168,
-0.22138018906116486,
0.05934523046016693,
0.0058188000693917274,
0.25428417325019836,
-0.29128536581993103,
0.02985234186053276,
0.5731309056282043,
-0.5741741061210632,
-0.3299447298049927,
0.001128649222664535,
-0.13895758986473083,
0.18236376345157623,
0.08715597540140152,
-0.31631529331207275,
-0.2419436275959015,
0.0012653791345655918,
-5.979823589324951,
0.10591817647218704,
-0.005324863828718662,
0.21312148869037628,
-0.06063476577401161,
-0.11378531157970428,
0.9704688787460327,
-0.012558654882013798,
-0.047993361949920654,
0.19837026298046112,
0.46434250473976135,
0.7363181710243225,
0.46838507056236267,
0.4357490539550781,
0.10640061646699905,
0.21296578645706177,
-0.013093320652842522,
-0.44090473651885986,
-0.031902801245450974,
-0.04355769231915474,
-0.21227304637432098,
-0.03821522369980812,
0.17681768536567688,
0.6025401949882507,
0.25675949454307556,
0.22393465042114258,
-1.074601173400879,
0.4319765269756317,
0.11328671127557755,
-0.04956964775919914,
-0.06754298508167267,
-0.3869849443435669,
0.5514213442802429,
-0.16189730167388916,
0.08761579543352127,
-0.13343559205532074,
-0.1713593304157257,
-0.24846315383911133,
-0.5970807075500488,
-0.3861906826496124,
0.14969483017921448,
-0.1242632120847702,
-0.21389733254909515,
0.16960902512073517,
0.06575021147727966,
-0.2806544303894043,
-0.18062126636505127,
-0.06879936903715134,
-0.12860450148582458,
1.0064218044281006,
-0.22198592126369476,
-0.10474983602762222,
0.016089173033833504,
0.47632548213005066,
0.2651808559894562,
-0.26865285634994507,
0.100029356777668,
0.13381879031658173,
-0.1817914992570877,
0.4329834282398224,
-0.4324386417865753,
-0.24102142453193665,
0.05600349232554436,
-0.367724746465683,
0.1936229169368744,
0.43715396523475647,
-0.9846550226211548,
-0.13762369751930237,
0.4350413382053375,
-0.11313030123710632,
-0.3790745437145233,
0.7206180691719055,
0.019697709009051323,
-0.9174550771713257,
0.1872740238904953,
-0.5225602388381958,
-0.36323311924934387,
-0.35972535610198975,
0.6091431379318237,
-0.048789385706186295,
0.1551617980003357,
-0.013835221529006958,
-0.2364804893732071,
0.13585256040096283,
0.18438629806041718,
-0.6579199433326721,
-0.027413884177803993,
-0.12497280538082123,
-0.42983952164649963,
-0.07281951606273651,
0.2682354152202606,
-0.046458903700113297,
0.3556349277496338,
0.2567368745803833,
0.23199975490570068,
0.9039437770843506,
-0.05273560434579849,
0.4177979528903961,
0.45886099338531494,
-0.24039724469184875,
1.017091155052185,
-0.12541088461875916,
-0.2687404453754425,
-0.6642669439315796,
0.4969770908355713,
0.07542848587036133,
-0.15421010553836823,
0.22578513622283936,
0.7502546310424805,
-0.5500926971435547,
0.29855144023895264,
0.34927332401275635,
-0.5798122882843018,
-0.5096226930618286,
0.41172176599502563,
-0.0366482138633728,
0.07216185331344604,
-0.11095428466796875,
0.8095056414604187,
-0.13597744703292847,
0.41352394223213196,
0.6774927377700806,
-0.06688397377729416,
-0.051328033208847046,
-0.31810468435287476,
-0.0032897628843784332,
0.39988160133361816,
0.6399208307266235,
-0.2613179683685303,
-0.22600696980953217,
0.2552363872528076,
0.4837689697742462,
-0.004533903207629919,
-0.39974045753479004,
0.2951960563659668,
-0.034398797899484634,
-0.2824654281139374,
0.0821366161108017,
-0.059651538729667664,
-0.3943603038787842,
-0.10543202608823776,
-0.09909337759017944,
-0.2883051037788391,
0.38038694858551025,
-0.03501961752772331,
-0.12716440856456757,
-0.1020231693983078,
-0.16448047757148743,
0.23350071907043457,
-0.31363019347190857,
0.16957280039787292,
-0.11476599425077438,
0.09395845234394073,
0.08892649412155151,
0.19572840631008148,
-0.13484348356723785,
0.5198282599449158,
0.07798004895448685,
0.22841261327266693,
-0.7127613425254822,
0.38276901841163635,
-0.3745362162590027,
-1.0161972045898438,
0.081210196018219,
0.07125870138406754,
-0.26247280836105347,
-0.039919521659612656,
-0.8445429801940918,
-0.017232976853847504,
0.5969681739807129,
-0.5072236657142639,
-0.12002260237932205,
-0.32395628094673157,
-0.031867850571870804,
-0.03836171701550484,
-0.3005478084087372,
-0.7997110486030579,
0.23704853653907776,
-0.05773249268531799,
-0.29471462965011597,
0.5257270336151123,
0.004792049061506987,
-0.4002813398838043,
-0.2651248276233673,
0.4089035391807556,
-0.0891842395067215,
-0.340742290019989,
-0.06255140155553818,
-0.18475943803787231,
-0.007189157884567976,
0.13881230354309082,
0.19207799434661865,
0.11710287630558014,
0.28752371668815613,
0.030074046924710274,
-0.016913097351789474,
-0.23675742745399475,
0.09269781410694122,
0.06836099177598953,
-0.4503917396068573,
0.2053157091140747,
0.85040682554245,
-0.20250074565410614,
-0.11898048222064972,
0.16004198789596558,
-0.10701391100883484,
0.89798903465271,
0.03408260643482208,
0.05092625692486763,
-0.29051512479782104,
-0.1725119650363922,
-0.24756065011024475,
0.1746009886264801,
0.8346501588821411,
-0.4620596468448639,
0.1651831567287445,
0.03754863888025284,
-0.1376735121011734,
0.01805582083761692,
0.03644610941410065,
0.8060684204101562,
0.18415264785289764,
0.017571961507201195,
0.0983106791973114,
-0.26607421040534973,
-0.02129092812538147,
0.8549280166625977,
-0.8561632037162781,
0.29863783717155457,
0.34644415974617004,
-0.06482112407684326,
-0.01675436645746231,
0.3432695269584656,
0.06942785531282425,
-0.5845478177070618,
-0.1574321687221527,
0.3200398087501526,
0.0768381655216217,
-0.20793414115905762,
0.09413333237171173,
0.13729950785636902,
0.5240110158920288,
-0.5970216393470764,
-0.1813361942768097,
0.2125953733921051,
0.7132468819618225,
-0.007623824756592512,
-0.11573359370231628,
-0.6171466708183289,
-0.04258006811141968,
0.3051230013370514,
0.1618901938199997,
0.07933023571968079,
0.42845460772514343,
0.5116899013519287,
-0.19788599014282227,
-0.2526923418045044,
0.02127240039408207,
-0.219085231423378,
0.16311240196228027,
-0.21908922493457794,
-0.14350895583629608,
0.26118549704551697,
0.16316922008991241,
-0.007852897047996521,
-0.33498576283454895,
-0.14373834431171417,
-0.39359229803085327,
0.23026232421398163,
-0.1028633564710617,
-0.10117215663194656,
0.19414126873016357,
0.9428750872612,
0.6576410531997681,
0.4455752968788147,
0.22787104547023773,
-0.6220473051071167,
-0.5026471614837646,
-0.42952391505241394,
0.38780999183654785,
-0.19714407622814178,
-0.6830872297286987,
0.07847054302692413,
-0.17774997651576996,
-0.272105872631073,
-0.30533307790756226,
0.5655237436294556,
-0.4479633867740631,
0.09848631918430328,
-0.5881088376045227,
-0.08621073514223099,
-0.2637570798397064,
-0.1366388201713562,
-0.5457301735877991,
-0.07905485481023788,
-0.12096195667982101,
0.05334119871258736,
0.04789815843105316,
0.07543625682592392,
-0.3951777517795563,
-0.8191801309585571,
0.32631751894950867,
0.6900678277015686,
-0.1850316822528839,
0.2796129286289215,
0.3058808445930481,
-0.2227197140455246,
0.004927873145788908,
-0.3557666838169098,
0.3996104896068573,
0.5497664213180542,
-0.2496742606163025,
0.16488823294639587,
0.4395603835582733,
-0.25934678316116333,
0.4592289626598358,
-0.03971678763628006,
-0.3161082863807678,
0.23020483553409576,
0.31452757120132446,
0.06799923628568649,
0.39609745144844055,
0.7106742262840271,
-0.0731411799788475,
0.011343393474817276,
0.2651301622390747,
-0.4793458580970764,
0.2711884379386902,
0.14335104823112488,
0.6375657916069031,
0.4461250603199005,
0.4758073389530182,
-0.23542796075344086,
0.463289350271225,
0.3598283529281616,
0.20675164461135864,
0.49146854877471924,
0.05373883619904518,
-0.1704503744840622,
0.08651694655418396,
0.8491125702857971,
-0.18421213328838348,
-0.04238119348883629,
-0.0798879936337471,
-0.3392660617828369,
0.2363230288028717,
-0.05737081170082092,
-0.2763139009475708,
-0.3227421045303345,
0.3030385971069336,
0.43250781297683716,
-0.3687806725502014,
-0.37994590401649475,
0.5915197134017944,
-0.39605918526649475,
0.21118375658988953,
0.3048584461212158,
-0.5764060616493225,
-0.7355599999427795,
-0.27052342891693115,
0.09738422930240631,
-0.007534060627222061,
-0.5661559700965881,
0.07037353515625,
-0.2034035474061966,
0.17359139025211334,
0.4488537907600403,
-0.6838982701301575,
0.13238051533699036,
0.2985508143901825,
-0.20431271195411682,
-0.2133195400238037,
-0.27724671363830566,
0.35119643807411194,
0.8776636123657227,
-0.17409823834896088,
0.5222153067588806,
0.5760863423347473,
0.3100954294204712,
-0.2651146650314331,
-0.9453341960906982,
0.18108397722244263,
-0.27421873807907104,
-0.577393651008606,
-0.13145284354686737,
0.10717262327671051,
-0.2076723575592041,
-0.4365512728691101,
-0.4383997321128845,
-0.17247463762760162,
-0.39990633726119995,
-0.2594282329082489,
0.39732158184051514,
0.21647542715072632,
0.1446952521800995,
-0.14798133075237274,
0.4543396830558777,
0.3600620925426483,
-0.21120613813400269,
0.2145957499742508,
-0.07009629905223846,
-0.13108500838279724,
-0.357523113489151,
-0.14986100792884827,
-0.42208975553512573,
0.6227370500564575,
-0.2553144693374634,
-0.2931564152240753,
-0.20571570098400116,
0.25217336416244507,
0.6380760669708252,
0.3479876220226288,
-0.20353816449642181,
-0.44037845730781555,
0.001628461992368102,
0.5338512659072876,
-0.18085035681724548,
-0.545823872089386,
-0.10325412452220917,
-0.37803924083709717,
-0.3045637905597687,
-0.33440709114074707,
0.6098438501358032,
-0.06397540867328644,
0.03827034682035446,
-0.17108450829982758,
0.3043460547924042,
0.6049140691757202,
-0.40042275190353394,
0.5347034335136414,
-0.030083658173680305,
0.3188638985157013,
-0.5129933953285217,
0.46116551756858826,
-0.6212921738624573,
-0.06330128759145737,
0.21158061921596527,
-0.08584048599004745,
-0.17248128354549408,
-0.04233134537935257,
0.13298168778419495,
-0.42531996965408325,
0.2841210663318634,
0.21791207790374756,
0.2648739516735077,
0.35186755657196045,
-0.2688193619251251,
-0.10031136125326157,
-0.7495177984237671,
0.289358526468277,
0.10885514318943024,
-0.3288085460662842,
-0.14592169225215912,
0.471819132566452,
-0.0027321737725287676,
0.37216219305992126,
0.13744695484638214,
-0.26349741220474243,
0.12051314860582352,
0.29541015625
] |
BACKGROUND The growing appreciation of the multi-faceted importance of optimal maternal nutrition to the health and development of the infant and young child is tempered by incompletely resolved strategies for combatting challenges. OBJECTIVE To review the importance of maternal nutrition and strategies being employed to optimize outcomes. METHODS Selected data from recent literature with special focus on rationale for and currently published results of maternal nutrition supplements, including lipid based nutrition supplements. RESULTS 1) An impelling rationale for improving the maternal and in utero environment of low resource populations has emerged to achieve improved fetal and post-natal growth and development. 2) Based partly on population increases in adult height over one-two generations, much can be achieved by reducing poverty. 3) Maternal, newborn and infant characteristics associated with low resource environments include evidence of undernutrition, manifested by underweight and impaired linear growth. 4) Apart from broad public health and educational initiatives, to date, most specific efforts to improve fetal growth and development have included maternal nutrition interventions during gestation. 5) The relatively limited but real benefits of both iron/folic acid (IFA) and multiple micronutrient (MMN) maternal supplements during gestation have now been reasonably defined. 6) Recent investigations of a maternal lipid-based primarily micronutrient supplement (LNS) have not demonstrated a consistent benefit beyond MMN alone. 7) However, effects of both MMN and LNS appear to be enhanced by commencing early in gestation. CONCLUSIONS Poor maternal nutritional status is one of a very few specific factors in the human that not only contributes to impaired fetal and early post-natal growth but for which maternal interventions have demonstrated improved in utero development, documented primarily by both improvements in low birth weights and by partial corrections of impaired birth length. A clearer definition of the benefits achievable by interventions specifically focused on correcting maternal nutrition deficits should not be limited to improvements in the quality of maternal nutrition supplements, but on the cumulative quantity and timing of interventions (also recognizing the heterogeneity between populations). Finally, in an ideal world these steps are only a prelude to improvements in the total environment in which optimal nutrition and other health determinants can be achieved. | [
0.022895678877830505,
0.015226082876324654,
-0.0032473085448145866,
0.020764946937561035,
0.014031627215445042,
-0.013101443648338318,
0.008302614092826843,
0.0006007947959005833,
-0.014067225158214569,
-0.04896693676710129,
-0.018032681196928024,
0.009175948798656464,
-0.002599532250314951,
0.008126851171255112,
-0.025663938373327255,
0.01722310483455658,
-0.0051966141909360886,
0.03421651944518089,
-0.00016181814135052264,
0.0029424044769257307,
-0.03199084475636482,
0.011730292811989784,
0.009245190769433975,
0.005726184695959091,
-0.00022830720990896225,
0.025019414722919464,
0.011027785949409008,
-0.016924533993005753,
0.0011883365223184228,
-0.0049265166744589806,
0.004493015818297863,
-0.01904665119946003,
0.03638434410095215,
0.008173742331564426,
0.0024326713755726814,
0.023254716768860817,
0.00043366989120841026,
0.01563439890742302,
0.0014846138656139374,
-0.002473921049386263,
0.02465062588453293,
-0.003528239671140909,
0.004746487829834223,
-0.004021272528916597,
-0.008208978921175003,
-0.015496036037802696,
0.0008292958373203874,
0.0028457704465836287,
-0.010413115844130516,
0.013308166526257992,
-0.0084498580545187,
-0.020617656409740448,
0.003006461076438427,
0.012092206627130508,
-0.005722999572753906,
0.009697780013084412,
0.019803548231720924,
-0.019187822937965393,
-0.04137174040079117,
0.02422212064266205,
0.01814451813697815,
-0.017469622194767,
0.0037935487926006317,
0.0256904698908329,
-0.005877985619008541,
-0.06733022630214691,
-0.011469013057649136,
-0.017696382477879524,
0.006427367217838764,
0.01949242316186428,
0.011901174671947956,
0.005197097081691027,
-0.015962814912199974,
-0.008016960695385933,
-0.0006066611967980862,
-0.004436152521520853,
0.003976268693804741,
0.004725317470729351,
0.03126293048262596,
0.027492595836520195,
0.010517075657844543,
0.0012815482914447784,
-0.03300889953970909,
0.014445329084992409,
0.017910830676555634,
0.0094577856361866,
-0.007259806618094444,
0.008554821833968163,
0.00981735996901989,
-0.006234769709408283,
0.010357835330069065,
0.0029720361344516277,
0.0043454477563500404,
-0.0006008935160934925,
0.0015402380377054214,
-0.002206308301538229,
-0.020364604890346527,
0.034100763499736786,
0.0377364456653595,
-0.006823757663369179,
-0.020637519657611847,
0.025357957929372787,
0.01642707549035549,
-0.011768581345677376,
-0.02111135981976986,
0.009204449132084846,
0.0032547321170568466,
0.021303774788975716,
-0.015453187748789787,
0.00530838780105114,
0.014737255871295929,
-0.0007148601580411196,
-0.01652693562209606,
-0.02027014084160328,
0.004614634905010462,
-0.014831040054559708,
0.016649728640913963,
-0.0011442848481237888,
0.010023701004683971,
0.002963809296488762,
0.0359712690114975,
-0.014329507015645504,
-0.002471423940733075,
0.012631948105990887,
0.0034599334467202425,
-0.007069072686135769,
-0.003014483954757452,
0.013066811487078667,
-0.03501050919294357,
0.0016180758830159903,
-0.008605831302702427,
0.011591775342822075,
0.0336972177028656,
-0.0070600626058876514,
0.013229122385382652,
0.0002038450911641121,
0.0021197907626628876,
-0.02345474809408188,
-0.0011964377481490374,
-0.010575074702501297,
0.011382673867046833,
0.008550915867090225,
-0.0036641061305999756,
0.0027117221616208553,
0.004949646536260843,
0.0008322963258251548,
0.004389983601868153,
0.010559285059571266,
-0.009530001319944859,
-0.009680901654064655,
0.00421641580760479,
-0.01726134866476059,
0.0006514335982501507,
-0.01199405174702406,
-0.006800594739615917,
-0.019977455958724022,
-0.00438793795183301,
-0.008117718622088432,
-0.01257401518523693,
0.0022698608227074146,
-0.005009289365261793,
-0.0038970238529145718,
0.0179116390645504,
0.009375534020364285,
0.022221140563488007,
0.010513353161513805,
-0.0032942662946879864,
0.00012736348435282707,
0.02342807687819004,
0.0002945066662505269,
-0.023031581193208694,
0.024623531848192215,
0.00349658215418458,
0.005336387548595667,
0.005668330937623978,
0.0024875840172171593,
-0.01961711049079895,
0.007765714079141617,
0.002587015274912119,
0.06720234453678131,
0.004213748034089804,
0.02784501574933529,
-0.028795242309570312,
-0.0044127777218818665,
-0.006292193662375212,
-0.002701203105971217,
0.04755112901329994,
-0.0030242376960814,
-0.013017641380429268,
-0.017170526087284088,
0.000619448721408844,
-0.008456365205347538,
0.025749649852514267,
0.016831010580062866,
-0.0067619383335113525,
0.0024863993749022484,
0.010371697135269642,
-0.004660978447645903,
-0.014739532954990864,
-0.03671238571405411,
-0.002540129702538252,
-0.001980839530006051,
0.025896232575178146,
0.0013860422186553478,
-0.019270462915301323,
-0.0005828692228533328,
0.009296297095716,
-0.010602675378322601,
0.0041429391130805016,
0.003983782604336739,
0.013891201466321945,
0.006854239385575056,
-0.008836310356855392,
-0.014347922056913376,
0.007846890017390251,
-0.022863592952489853,
-0.01721467263996601,
0.0016392134130001068,
0.006242488976567984,
-0.01634172722697258,
0.0020532000344246626,
0.001282403478398919,
0.011790324933826923,
-0.018151871860027313,
-0.004490369465202093,
0.00973578728735447,
0.0024489467032253742,
0.010946076363325119,
0.0022819694131612778,
-0.005382835399359465,
-0.008740793913602829,
-0.003567666746675968,
-0.007277880795300007,
0.01666220650076866,
0.004627624060958624,
0.017907286062836647,
0.010660314001142979,
-0.006670382805168629,
0.017925892025232315,
-0.004881156608462334,
0.0038661144208163023,
-0.02450546622276306,
0.014809755608439445,
-0.017716601490974426,
0.015386704355478287,
-0.029136614874005318,
-0.022395920008420944,
0.011778296902775764,
0.008038189262151718,
-0.01922721229493618,
-0.0011307729873806238,
-0.0062967147678136826,
-0.021830745041370392,
-0.014700586907565594,
-0.014361652545630932,
0.013382292352616787,
0.0032556462101638317,
0.005523533560335636,
0.02221880480647087,
-0.025357184931635857,
0.01556325051933527,
0.009487717412412167,
-0.04057735204696655,
-0.009787780232727528,
0.02150396816432476,
-0.001523380633443594,
0.007599388249218464,
0.024122091010212898,
-0.0178988017141819,
0.034343596547842026,
0.006660487502813339,
-0.008619057945907116,
0.0011085757287219167,
-0.0815424844622612,
-0.011007033288478851,
0.014155718497931957,
-0.01901891455054283,
0.010208101943135262,
-0.008119658567011356,
-0.00588292395696044,
0.01594841480255127,
-0.013105208054184914,
-0.004668186418712139,
-0.013558298349380493,
0.02983516827225685,
-0.003517237026244402,
-0.018102945759892464,
0.01525669451802969,
-0.0009112485568039119,
0.0007265283493325114,
-0.03348797187209129,
0.006712884176522493,
0.0066976179368793964,
0.010830381885170937,
-0.009673139080405235,
-0.0015351970214396715,
-0.01161749754101038,
-0.0076277973130345345,
0.038926027715206146,
0.03193109855055809,
-0.007288916502147913,
0.008680496364831924,
0.01557423360645771,
-0.00818113423883915,
-0.030239982530474663,
-0.007205525413155556,
0.00039374129846692085,
-0.003395246108993888,
0.025205425918102264,
-0.006389674264937639,
-0.004791273269802332,
-0.012172436341643333,
0.009265482425689697,
-0.006175752729177475,
0.01821368746459484,
-0.004878220614045858,
-0.018768606707453728,
0.00020442577078938484,
0.007901210337877274,
0.011683991178870201,
-0.028412507846951485,
0.0014576667454093695,
-0.009426180273294449,
0.005367929115891457,
0.0001903419615700841,
0.0018205788219347596,
0.010314811952412128,
-0.008350241929292679,
-0.0235094353556633,
-0.0013113163877278566,
0.009978988207876682,
-0.010384051129221916,
-0.013279648497700691,
-0.005177561193704605,
-0.0035406770184636116,
0.0070051951333880424,
0.02949628233909607,
-0.006432883441448212,
-0.015355544164776802,
0.005658320616930723,
-0.002906255191192031,
-0.01077533233910799,
0.005950375460088253,
0.020186327397823334,
0.012879829853773117,
0.015408486127853394,
0.002181581687182188,
0.007332491222769022,
-0.019461937248706818,
-0.016596175730228424,
0.008117269724607468,
0.013216312974691391,
0.002278225729241967,
0.0033429190516471863,
-0.0015082759782671928,
0.013238191604614258,
-0.00568745331838727,
0.0015645918902009726,
0.005779606755822897,
0.0016505748499184847,
0.015962224453687668,
-0.00405000988394022,
-0.013069127686321735,
0.0015070601366460323,
0.004865890368819237,
0.010392802767455578,
0.002112229820340872,
0.005067856982350349,
-0.004230037331581116,
0.01606973633170128,
-0.022219177335500717,
0.013350792229175568,
0.00857341755181551,
-0.011627299711108208,
0.010099666193127632,
-0.01995587907731533,
-0.01629524491727352,
-0.008554849773645401,
0.008415374904870987,
0.00015281885862350464,
0.001616134773939848,
0.004294270183891058,
-0.010560219176113605,
-0.003710450604557991,
-0.006823369301855564,
-0.005607889965176582,
0.017813876271247864,
0.010458726435899734,
0.019690558314323425,
-0.0076726577244699,
-0.00937998853623867,
0.07279392331838608,
0.0015694079920649529,
-0.013223424553871155,
-0.0030930684879422188,
-0.017332136631011963,
-0.026995521038770676,
-0.023034095764160156,
0.0062034642323851585,
0.0056606801226735115,
-0.01507040485739708,
0.010905134491622448,
0.022165805101394653,
0.005861232988536358,
0.0004959944635629654,
-0.01339156273752451,
-0.01696213334798813,
0.005124267190694809,
-0.01623040996491909,
0.004188451915979385,
0.006428319960832596,
-0.013015635311603546,
-0.006554984487593174,
-0.0033420096151530743,
-0.015447063371539116,
0.007747113239020109,
-0.009562680497765541,
-0.0023592025972902775,
-0.011263811960816383,
0.002616965677589178,
-0.004884281195700169,
-0.0016511736903339624,
0.010569194331765175,
0.000160481984494254,
-0.017491836100816727,
0.010509110987186432,
-0.0021189898252487183,
0.010037441737949848,
-0.029162615537643433,
0.0014832132728770375,
-0.002183622680604458,
-0.02049831859767437,
-0.010494282469153404,
0.01992432400584221,
0.006613416597247124,
-0.006978044752031565,
-0.010146590881049633,
0.00789058767259121,
-0.006818919908255339,
-0.013962341472506523,
0.007456357590854168,
0.006168121472001076,
0.005110942292958498,
0.00590435741469264,
0.021144893020391464,
-0.008595054037868977,
0.01582402177155018,
-0.00977935828268528,
-0.0006800697883591056,
0.0037763072177767754,
-0.007865328341722488,
-0.028594378381967545,
-0.009587615728378296,
0.01967724785208702,
-0.02504771016538143,
-0.010574273765087128,
-0.012503553181886673,
-0.0012680733343586326,
-0.010898919776082039,
0.033327728509902954,
-0.021350281313061714,
-0.008434167131781578,
-0.00986742414534092,
-0.00015060941223055124,
0.025207186117768288,
-0.0035042641684412956,
-0.0199718177318573,
-0.0034348643384873867,
-0.026103174313902855,
-0.005334837362170219,
-0.0018864304292947054,
-0.020613200962543488,
0.011675852350890636,
-0.00708116265013814,
-0.0014633317478001118,
-0.0013614916242659092,
-0.013699036091566086,
0.0017918834928423166,
-0.07499851286411285,
-0.003644146490842104,
0.002930103335529566,
-0.007505651097744703,
-0.030262529850006104,
0.00540431821718812,
-0.013525297865271568,
0.00696929544210434,
-0.027587302029132843,
0.0032548157032579184,
-0.0347273088991642,
-0.006617874372750521,
-0.001622201525606215,
0.012742194347083569,
0.011700275354087353,
0.004413198679685593,
-0.01770138368010521,
0.007476632948964834,
-0.0010239025577902794,
-0.023816976696252823,
0.013115089386701584,
-0.011353783309459686,
-0.015290872193872929,
0.007112893275916576,
0.006063946057111025,
-0.08152392506599426,
0.0093535166233778,
0.006125250365585089,
0.02101634256541729,
-0.009698117151856422,
-0.022450361400842667,
0.015429211780428886,
-0.009139474481344223,
0.01577088050544262,
-0.016630878672003746,
0.0016629804158583283,
0.0022654966451227665,
-0.0021872036159038544,
-0.002173155313357711,
0.020681383088231087,
-0.003858794691041112,
0.005911470390856266,
-0.03224701061844826,
-0.002680729841813445,
-0.03651268035173416,
0.009327555075287819,
-0.00232717115432024,
-0.00909506157040596,
0.00019612477626651525,
-0.005987869575619698,
-0.009204353205859661,
-0.006344524212181568,
0.013700257055461407,
-0.0025281663984060287,
0.008103062398731709,
0.006544949486851692,
0.0029409751296043396,
-0.00504075875505805,
-0.0031223418191075325,
-0.0011673239059746265,
-0.007325062062591314,
0.011637603864073753,
-0.012969505973160267,
0.00018470606300979853,
-0.01840035431087017,
-0.00603535957634449,
-0.008346250280737877,
0.0009756339713931084,
0.002514015883207321,
-0.009523455053567886,
-0.004701722413301468,
0.002692962996661663,
-0.0023103507701307535,
-0.004370087757706642,
-0.032194584608078,
0.009846305474638939,
-0.009232052601873875,
0.025457795709371567,
-0.003913273103535175,
-0.022332021966576576,
0.03125555440783501,
-0.0035382432397454977,
0.0034229604061692953,
0.02203989028930664,
0.0064963726326823235,
-0.00029764685314148664,
0.03234149515628815,
0.016364218667149544,
0.07245315611362457,
-0.026088837534189224,
0.01007450744509697,
0.011758117936551571,
0.002062150277197361,
-0.003587555605918169,
-0.007687093690037727,
-0.004422160796821117,
0.038781438022851944,
-0.02418576553463936,
-0.003292033914476633,
-0.017316777259111404,
-0.012233125977218151,
0.00533615006133914,
0.004645003005862236,
0.0019362077582627535,
0.0070067644119262695,
0.015751728788018227,
0.005313912406563759,
0.023694932460784912,
0.03146839514374733,
-0.013793472200632095,
-0.019375842064619064,
0.005539738107472658,
0.008777222596108913,
-0.020753461867570877,
-0.008258364163339138,
0.019833922386169434,
-0.01692582666873932,
-0.00034341728314757347,
-0.00590102095156908,
-0.005568378139287233,
-0.0004686929751187563,
0.0024908394552767277,
0.019203733652830124,
0.026855532079935074,
0.004787814803421497,
-0.009173252619802952,
-0.020487846806645393,
0.006806459277868271,
0.03223128989338875,
-0.01939789019525051,
-0.004549714736640453,
0.01604890264570713,
0.02009991742670536,
-0.006270013749599457,
-0.006286749616265297,
0.002397507429122925,
-0.015792116522789,
-0.0030696599278599024,
-0.03366846963763237,
-0.0030430853366851807,
0.012221528217196465,
0.011954763904213905,
-0.002704826183617115,
0.00712684728205204,
-0.024295734241604805,
0.012738166376948357,
0.027755580842494965,
-0.0245668962597847,
-0.0058200778439641,
-0.017395908012986183,
0.055027276277542114,
-0.0015576679725199938,
0.02021942287683487,
0.00913233496248722,
0.0015362848062068224,
-0.007916133850812912,
-0.008347501046955585,
0.012722933664917946,
-0.005011472385376692,
-0.013509383425116539,
-0.003061375580728054,
-0.011121593415737152,
0.02039894461631775,
-0.001754377968609333,
0.0036706747487187386,
-0.022938858717679977,
0.024577969685196877,
-0.011173653416335583,
-0.004756345879286528,
0.017540138214826584,
0.01908450573682785,
-0.03407709300518036,
0.017869651317596436,
0.022274009883403778,
0.03465616703033447,
0.020049646496772766,
-0.0033621513284742832,
0.008393429219722748,
-0.0036572981625795364,
-0.004949708469212055,
-0.0008486839360557497,
0.013933259062469006,
0.003009003819897771,
0.03339017182588577,
-0.0021694698370993137,
0.007181234657764435,
0.0050843702629208565,
0.02374621108174324,
0.01672656275331974,
0.020891880616545677,
0.00712965615093708,
-0.007496568374335766,
0.004319840110838413,
-0.006295265629887581,
0.006178810261189938,
-0.01855423115193844,
0.035775326192379,
0.01623787358403206,
-0.01724984124302864,
-0.04780576750636101,
0.006670301780104637,
0.012751606293022633,
-0.0060774702578783035,
0.009921673685312271,
0.01107417605817318,
0.002644076943397522,
-0.02786606177687645,
-0.006999550852924585,
-0.02376309409737587,
-0.0008584028109908104,
0.03187033534049988,
0.014958279207348824,
-0.006781801115721464,
-0.005085648037493229,
-0.007664530538022518,
0.013458572328090668,
0.028212416917085648,
-0.0016118637286126614,
0.007745628245174885,
-0.03146342188119888,
0.01565593108534813,
0.02764611318707466,
-0.0040987636893987656,
0.01175348274409771,
-0.0035909367725253105,
0.006189321167767048,
-0.0001789899542927742,
0.024325724691152573,
0.018888235092163086,
0.005026524420827627,
-0.008988551795482635,
0.020333200693130493,
0.007682377472519875,
0.013778779655694962,
0.01716449297964573,
0.02813556231558323,
0.01627662032842636,
0.010430477559566498,
0.002288278192281723,
0.0134218018501997,
0.000778506975620985,
0.0007065866375342011,
-0.017759446054697037,
0.030230771750211716,
-0.0015003189910203218,
0.056451812386512756,
-0.0077679050154984,
-0.008996544405817986,
0.026807721704244614,
-0.005465114489197731,
0.006901230663061142,
0.007191970944404602,
-0.021129177883267403,
0.0014216029085218906,
-0.013070530258119106,
-0.004481553100049496,
-0.013517066836357117,
0.004707843530923128,
-0.004558122251182795,
-0.015638429671525955,
-0.011908350512385368,
0.019504765048623085,
-0.022992920130491257,
-0.001909930957481265,
0.0016087223775684834,
0.017963960766792297,
-0.02104061469435692,
-0.008081777021288872,
-0.0075653716921806335,
0.0020246230997145176,
-0.005803657695651054,
-0.008830398321151733,
0.007093057036399841,
0.010022982023656368,
0.0014877866487950087,
0.0049612452276051044,
0.00836915522813797,
-0.02935832366347313,
-0.0070418184623122215,
-0.010464978404343128,
-0.015225142240524292,
-0.01571597158908844,
-0.003764952765777707,
-0.02717360109090805,
0.001118464395403862,
-0.02406173013150692,
-0.009326133877038956,
-0.0009422721341252327,
-0.01686488837003708,
-0.006928517483174801
] | [
0.463075190782547,
0.03735993057489395,
-0.32891717553138733,
0.3464856445789337,
0.38944050669670105,
0.6962693929672241,
-0.0666557177901268,
-0.02743142656981945,
-0.007983924821019173,
-0.6912002563476562,
0.21218492090702057,
0.6900750398635864,
0.2853882312774658,
-0.0683562159538269,
-0.46700966358184814,
0.6863575577735901,
0.49701109528541565,
0.4771201014518738,
-0.021084554493427277,
-0.4501703381538391,
-0.5159118175506592,
-0.23246099054813385,
0.3221835792064667,
-0.024926239624619484,
0.2896421551704407,
0.3227733075618744,
0.3183852732181549,
0.24713942408561707,
-0.20224529504776,
0.10187903791666031,
-0.5058884620666504,
0.40929481387138367,
-0.002715703332796693,
0.18352605402469635,
0.2617470324039459,
-0.3715904653072357,
0.2076922357082367,
0.11238905042409897,
0.1753474771976471,
-0.3056468367576599,
-0.11261089891195297,
0.046490564942359924,
0.020655348896980286,
0.4235454797744751,
-0.0418732725083828,
-0.38974419236183167,
-1.307496190071106,
-0.12475103884935379,
-0.4616294801235199,
-0.13873173296451569,
0.51206374168396,
0.30889594554901123,
0.002435149857774377,
0.16974462568759918,
0.13583438098430634,
0.24385111033916473,
0.04370734468102455,
-0.017807990312576294,
0.266732782125473,
-0.34232041239738464,
-0.2030458003282547,
0.13268375396728516,
-0.07401219755411148,
0.0067864106968045235,
-0.017988115549087524,
0.3612583577632904,
0.16010864078998566,
-0.14976873993873596,
-0.03185664489865303,
-0.06895750015974045,
-0.6585478782653809,
-0.08235576748847961,
-0.3614750802516937,
0.295127272605896,
-0.4053821861743927,
0.32977890968322754,
0.20545701682567596,
0.24315279722213745,
0.21369969844818115,
-0.5240778923034668,
0.35883796215057373,
-0.4412682354450226,
-0.11368052661418915,
-0.3247142434120178,
0.4072459936141968,
0.22739970684051514,
0.4806850552558899,
0.24153289198875427,
-0.4953555166721344,
-0.0565451979637146,
0.11527156829833984,
-0.4054969549179077,
-0.11126840114593506,
0.7797164916992188,
-0.051787640899419785,
0.15591083467006683,
0.3954111337661743,
-0.25936993956565857,
0.4345959722995758,
0.16730816662311554,
-0.029965968802571297,
0.029883606359362602,
0.07496451586484909,
0.10408653318881989,
-0.4451141655445099,
-0.42041271924972534,
-0.06242407485842705,
-0.1412930190563202,
-0.8492419123649597,
0.5111051201820374,
-0.5876545310020447,
0.5536960363388062,
0.14279253780841827,
-0.017331775277853012,
-0.17943744361400604,
0.36998894810676575,
-0.14342547953128815,
-0.20488780736923218,
-0.48049965500831604,
0.22374427318572998,
-0.01667097397148609,
0.8421605229377747,
-0.4362025260925293,
0.4140213131904602,
0.27724504470825195,
0.1232517808675766,
0.561862587928772,
0.4492158591747284,
-0.0515916682779789,
0.6657403111457825,
-0.011816488578915596,
0.11518544703722,
-0.5222076177597046,
0.0666126236319542,
-0.2829720973968506,
-0.17370304465293884,
0.5189231634140015,
0.17344430088996887,
0.4263509213924408,
0.23295480012893677,
-0.5730322599411011,
-0.5935330986976624,
0.30295422673225403,
-0.2095707654953003,
0.5927152633666992,
-0.6865978240966797,
0.058059804141521454,
-0.12301525473594666,
-0.4091578722000122,
-0.1168687641620636,
0.5082123279571533,
0.09063412994146347,
-0.5271461606025696,
-0.2378474920988083,
-0.19297999143600464,
0.3715771734714508,
0.3175950348377228,
-0.40941449999809265,
-0.29836753010749817,
0.3987928330898285,
0.1908619999885559,
0.5633643269538879,
-0.3668603003025055,
-0.42987295985221863,
0.3955869972705841,
-0.3092263340950012,
0.30960777401924133,
-0.1925920993089676,
-0.06271510571241379,
0.7319177985191345,
-0.44401609897613525,
0.10264140367507935,
-0.5075257420539856,
-0.5719369053840637,
0.13520538806915283,
0.23487353324890137,
0.4447675943374634,
0.01268253568559885,
0.25584933161735535,
-0.06292148679494858,
-0.5571252703666687,
0.2118503451347351,
-0.09656833857297897,
-0.8185603618621826,
-0.2046770304441452,
-0.22256262600421906,
0.39107608795166016,
-0.20049721002578735,
0.22377488017082214,
-0.3526974022388458,
-0.49702170491218567,
-0.3158477544784546,
0.9052172303199768,
-0.7378571629524231,
1.3117756843566895,
-0.5273680686950684,
0.013034990057349205,
0.9844183921813965,
-0.03268667310476303,
0.13868828117847443,
0.23279809951782227,
-0.02147316373884678,
0.04631729796528816,
0.053398311138153076,
-0.8030046224594116,
0.37564408779144287,
0.5561336278915405,
-0.5457888841629028,
-0.06752687692642212,
-0.03283459320664406,
0.6431615948677063,
0.28954342007637024,
-0.40875375270843506,
-0.3825889825820923,
0.0857376903295517,
-0.13146665692329407,
-0.018506981432437897,
0.3201395273208618,
-0.14035862684249878,
0.09315887093544006,
0.20843754708766937,
-0.5534188747406006,
0.41562288999557495,
0.34115612506866455,
0.21353480219841003,
0.11964179575443268,
0.4505043625831604,
-0.2560266852378845,
0.3263264000415802,
-0.3974991738796234,
0.06109558045864105,
0.40812423825263977,
0.2891991138458252,
-0.5668811798095703,
-0.5295578837394714,
-0.12652038037776947,
-0.04057842120528221,
0.285993754863739,
-0.007630629930645227,
0.2092086225748062,
-0.2041022628545761,
0.5210208296775818,
-0.9371358752250671,
0.06664369255304337,
-0.22641006112098694,
-0.3658643364906311,
-0.7151614427566528,
0.5006272792816162,
-0.9234622716903687,
-0.09520795196294785,
0.03372160717844963,
0.07737962901592255,
0.13754025101661682,
-0.5199264883995056,
-0.2739250361919403,
0.03798060119152069,
-0.45309045910835266,
-0.7155831456184387,
0.5621929168701172,
-0.4767916202545166,
0.03746846318244934,
0.5686489343643188,
0.421671599149704,
-0.13983504474163055,
0.32835930585861206,
-0.3653973639011383,
-0.4396094083786011,
-0.7510272860527039,
0.7151931524276733,
0.5211942195892334,
0.6144157648086548,
0.0073516895063221455,
-0.680110514163971,
-0.05086991563439369,
-0.05101307854056358,
-0.860571026802063,
0.5203093886375427,
0.6959764361381531,
-0.6304440498352051,
-0.6550453305244446,
0.30495136976242065,
0.43268251419067383,
0.751116931438446,
-0.005892537999898195,
-0.46657997369766235,
-0.25386396050453186,
0.30348584055900574,
-0.23581428825855255,
-0.48515069484710693,
0.24943362176418304,
-0.292833536863327,
0.5203705430030823,
-0.20728671550750732,
-0.5578975081443787,
0.8598106503486633,
0.7111314535140991,
-0.3762136697769165,
0.027874641120433807,
0.3252156972885132,
-0.04130395129323006,
0.3359358310699463,
0.37574079632759094,
0.27265509963035583,
-0.1679151952266693,
-0.18043987452983856,
0.08942416310310364,
-0.7013161778450012,
-0.1588478535413742,
-5.857632160186768,
-0.03614430129528046,
-0.07747799903154373,
-0.3225859999656677,
-0.105583555996418,
-0.1067848727107048,
0.9259829521179199,
-0.16342730820178986,
0.43209001421928406,
-0.3978653848171234,
0.3071049749851227,
0.4875606894493103,
0.07240711152553558,
0.35912641882896423,
0.4022260010242462,
0.09056209027767181,
0.707483172416687,
-0.25324922800064087,
0.5685786604881287,
0.5357071757316589,
0.1490001529455185,
-0.3054817020893097,
-0.07309788465499878,
0.3633604943752289,
0.2943441867828369,
0.4494713544845581,
-1.138198971748352,
0.3578713834285736,
-0.04818045347929001,
-0.2784861922264099,
0.38734427094459534,
-0.9438154101371765,
-0.3036525249481201,
-0.40251749753952026,
0.45365628600120544,
0.3723141849040985,
0.07085955142974854,
0.13958172500133514,
0.3428490459918976,
0.05715026706457138,
0.2463134229183197,
0.5390637516975403,
-0.03524450957775116,
0.19047676026821136,
0.25605031847953796,
0.34014561772346497,
0.27307817339897156,
0.16224654018878937,
-0.4137656092643738,
0.9640482068061829,
-0.08165952563285828,
-0.022132132202386856,
-0.03207400068640709,
0.14014163613319397,
0.218633234500885,
0.07489729672670364,
0.3954468369483948,
0.13341489434242249,
-0.284826397895813,
0.40729811787605286,
0.10788936167955399,
-0.5932638049125671,
0.43126651644706726,
-0.5506002306938171,
-0.162273108959198,
0.06158626079559326,
-0.7983452677726746,
-0.5947921872138977,
-0.35066941380500793,
-0.009789446368813515,
-0.2458140105009079,
-0.13020473718643188,
0.40473249554634094,
-0.607763946056366,
0.03441719710826874,
-0.5590952634811401,
-0.01044031698256731,
0.043354958295822144,
-0.022087322548031807,
-0.44062402844429016,
-0.16439583897590637,
-0.05680801346898079,
0.5555034875869751,
0.37862628698349,
0.19769951701164246,
0.4596409499645233,
-0.2093231976032257,
-0.23008455336093903,
-0.4816080927848816,
0.23127910494804382,
0.5878357887268066,
-0.6448248028755188,
0.013455360196530819,
0.41516733169555664,
0.8560620546340942,
0.9537307620048523,
0.48176077008247375,
-0.239436075091362,
0.2389305979013443,
-0.2572794556617737,
0.44859740138053894,
-0.09916029870510101,
-0.21842147409915924,
-0.7460373044013977,
-0.20687928795814514,
-0.10793966054916382,
-0.5454040169715881,
-0.17838174104690552,
0.4816357493400574,
-1.1833312511444092,
0.00040417793206870556,
0.06114106997847557,
-0.3815024793148041,
-0.240310400724411,
0.45731550455093384,
-0.12575691938400269,
-0.4155561923980713,
-0.01391836628317833,
0.4140465557575226,
0.17562457919120789,
0.42143070697784424,
0.0832379013299942,
-0.01000022143125534,
0.4270189106464386,
-0.2240055948495865,
-0.7581668496131897,
0.47459912300109863,
0.2251700907945633,
-0.6954297423362732,
0.13742277026176453,
0.39747732877731323,
0.3362869918346405,
-0.5200859308242798,
-0.09760028123855591,
-0.13261990249156952,
-0.31193646788597107,
-0.02878391742706299,
0.030156051740050316,
0.3192994296550751,
0.22338740527629852,
-0.20319923758506775,
-0.011930433101952076,
-0.240010604262352,
0.10128341615200043,
0.8764747381210327,
-0.032607175409793854,
-0.37941092252731323,
0.1015048697590828,
-0.06274750083684921,
0.030240608379244804,
0.01199314370751381,
0.30201926827430725,
0.4861701726913452,
-0.4794093370437622,
-0.4336881637573242,
-0.06667036563158035,
0.36477598547935486,
0.13554567098617554,
-0.21922431886196136,
-0.44209352135658264,
0.613738477230072,
-0.012168915942311287,
-1.0040013790130615,
0.004319723695516586,
-0.030827591195702553,
-0.3424302339553833,
0.11911394447088242,
-0.5572348237037659,
0.17164862155914307,
0.20058363676071167,
0.3204967975616455,
-0.4426601529121399,
0.121347576379776,
-0.16318467259407043,
0.10409548878669739,
-0.32946670055389404,
-0.1008002832531929,
0.5166234374046326,
-0.029202599078416824,
-0.36791932582855225,
0.0383329764008522,
-0.5935317873954773,
-0.1290680468082428,
0.08776721358299255,
1.0063836574554443,
0.5656709671020508,
0.056142620742321014,
-0.12450046837329865,
-0.3975507616996765,
-0.18331359326839447,
0.0342910960316658,
-0.012872107326984406,
0.8512364625930786,
0.04584633186459541,
-0.1486985981464386,
-0.07911861687898636,
0.21285292506217957,
0.2826334834098816,
-0.25012001395225525,
-0.23195840418338776,
-0.19472751021385193,
0.23756465315818787,
-0.40228164196014404,
0.5667895674705505,
0.3089485466480255,
-0.3482190668582916,
-0.09558939188718796,
-0.12427275627851486,
-0.33548980951309204,
-0.11437921226024628,
-0.16682517528533936,
-0.24782684445381165,
-0.3494388461112976,
0.2640873193740845,
-0.6067127585411072,
-0.11506049335002899,
0.20428018271923065,
0.12698541581630707,
-0.49359211325645447,
0.40900129079818726,
0.8819819092750549,
-0.4728555977344513,
-0.41525909304618835,
0.37592026591300964,
-0.19318555295467377,
-0.08377037197351456,
1.0325719118118286,
-0.8155179619789124,
-0.16747227311134338,
-0.10457460582256317,
-0.963533341884613,
0.059196837246418,
0.28712669014930725,
-0.02109052613377571,
-0.9240004420280457,
0.08513006567955017,
-0.13987815380096436,
0.2915045917034149,
0.13303174078464508,
0.2557869851589203,
0.030100341886281967,
0.5270401239395142,
0.10641691833734512,
-1.0949459075927734,
-0.16502735018730164,
0.6405462622642517,
0.19594071805477142,
-0.40594232082366943,
-0.5014223456382751,
0.4419800937175751,
0.3735109567642212,
-0.40372025966644287,
-0.15178819000720978,
-0.2670780420303345,
0.10843610763549805,
-0.07661109417676926,
-0.39312607049942017,
-0.34834691882133484,
-0.04153166338801384,
0.40539389848709106,
-0.04644997417926788,
-0.9767717719078064,
-0.07760344445705414,
-0.30184057354927063,
0.11896240711212158,
-0.4267725348472595,
-0.1254897117614746,
-0.3329576253890991,
0.21230940520763397,
-0.32058027386665344,
-0.07297198474407196,
0.06203729659318924,
0.501919686794281,
-0.04510745406150818,
0.40365785360336304,
-0.15407001972198486,
-0.2639632821083069,
0.10422578454017639,
-0.0011851051822304726,
0.2343437671661377,
-0.3699342608451843,
-0.6565647125244141,
0.1945393681526184,
-0.4970827102661133,
0.12375345826148987,
-0.4600032567977905,
0.3669036030769348,
-0.028676781803369522,
-0.06324717402458191,
-0.5506199598312378,
-0.3680441081523895,
0.025928176939487457,
-0.4626390337944031,
-0.6570149064064026,
-0.016650928184390068,
0.23407600820064545,
0.27529430389404297,
0.03561897948384285,
0.5863155722618103,
-0.5645046830177307,
-0.06947808712720871,
0.8411468863487244,
0.04102153703570366,
-0.521043598651886,
0.6160178780555725,
0.47142186760902405,
-0.06861645728349686,
-0.3542294204235077,
-0.011888500303030014,
0.0864991843700409,
0.4366625249385834,
0.1930418759584427,
0.4865773618221283,
0.4721248745918274,
0.005895416252315044,
0.06080583110451698,
-0.19777150452136993,
-0.6252294778823853,
0.9332359433174133,
0.5995498299598694,
-0.052035294473171234,
0.27600616216659546,
0.7559705376625061,
-0.24857068061828613,
-0.17052201926708221,
0.2415379136800766,
-0.2195204347372055,
0.1423252373933792,
0.06458976864814758,
-0.09353719651699066,
0.08409000933170319,
0.832195520401001,
0.0028158938512206078,
0.012094320729374886,
0.14807219803333282,
0.7112318873405457,
0.27334028482437134,
-0.7358846664428711,
-0.26889532804489136,
0.08700409531593323,
0.9108991026878357,
0.17352716624736786,
0.12145613878965378,
-0.26411500573158264,
-0.22643697261810303,
0.1684960126876831,
0.18345992267131805,
0.12725135684013367,
-0.5625675320625305,
0.4917896091938019,
-0.1569463163614273,
-0.3337668180465698,
-0.3626648187637329,
-0.17355167865753174,
0.04415339231491089,
0.18964582681655884,
0.2526155114173889,
-0.24806345999240875,
-0.7807489633560181,
0.17331768572330475,
0.049689311534166336,
0.3084873855113983,
-0.20564110577106476,
0.08434723317623138,
-0.31276339292526245,
0.04641769081354141,
0.6037708520889282,
0.2432490736246109,
0.22815290093421936,
-0.21338903903961182,
-0.16837741434574127,
-0.1552024930715561,
-0.12808047235012054,
0.01689250022172928,
0.13767866790294647,
-0.7948275208473206,
0.13411766290664673,
-0.025160368531942368,
0.09419243037700653,
0.3755844235420227,
0.22551248967647552,
-0.09259343892335892,
-0.2830936014652252,
-0.14484429359436035,
0.12443499267101288,
0.0010058707557618618,
-0.32845208048820496,
0.1271294504404068,
0.005007828585803509,
-0.024581946432590485,
-0.22612862288951874,
-0.4866246283054352,
0.3486041724681854,
0.5280457139015198,
-0.37651288509368896,
0.13008785247802734,
-0.08807705342769623,
0.9451178312301636,
0.3598843216896057,
-0.25522708892822266,
-0.3893507122993469,
0.10066891461610794,
-0.37412405014038086,
0.8771300315856934,
-0.017538834363222122,
0.26411569118499756,
-0.7450360655784607,
-0.1455228477716446,
-0.7834938764572144,
-0.08026023209095001,
0.48283201456069946,
0.0835285633802414,
-0.20512987673282623,
0.12831005454063416,
0.00025938652106560767,
0.32117363810539246,
0.45666614174842834,
-0.002833646023645997,
-0.13227945566177368,
-0.5035809874534607,
0.09839847683906555,
-0.6703647375106812,
0.22953221201896667,
-0.026871245354413986,
-0.25533953309059143,
-0.5571446418762207,
-0.012454118579626083,
0.8580850958824158,
-0.3444810211658478,
0.3782855272293091,
-0.49280229210853577,
-0.5976014733314514,
-0.4063131809234619,
0.6419268250465393,
-0.36752286553382874,
0.5982849597930908,
0.28558096289634705,
0.05326459929347038,
0.5526650547981262,
-0.46585795283317566,
-0.41868990659713745,
-0.3544073700904846,
0.5639036893844604,
0.30463865399360657,
-0.17610926926136017,
0.1717110425233841,
-0.17209705710411072,
-0.1895391196012497,
-0.47429096698760986,
0.4278245270252228,
-0.3661998212337494,
-0.22748467326164246,
-0.15535514056682587,
-0.0849740281701088,
-0.4083559513092041,
-0.375480592250824,
-0.04394268989562988,
-0.3600084185600281,
-0.4338628649711609,
-0.6851878762245178
] |
The introduction of immune-checkpoint blockade in the cancer therapy led to a paradigm change of the management of late stage cancers. There are already multiple FDA approved checkpoint inhibitors and many other agents are undergoing phase 2 and early phase 3 clinical trials. The therapeutic indication of immune checkpoint inhibitors expanded in the last years, but still remains unclear who can benefit. MicroRNAs are small RNAs with no coding potential. By complementary pairing to the 3' untranslated region of messenger RNA, microRNAs exert posttranscriptional control of protein expression. A network of microRNAs directly and indirectly controls the expression of checkpoint receptors and several microRNAs can target multiple checkpoint molecules, mimicking the therapeutic effect of a combined immune checkpoint blockade. In this review, we will describe the microRNAs that control the expression of immune checkpoints and we will present four specific issues of the immune checkpoint therapy in cancer: (1) imprecise therapeutic indication, (2) difficult response evaluation, (3) numerous immunologic adverse-events, and (4) the absence of response to immune therapy. Finally, we propose microRNAs as possible solutions for these pitfalls. We consider that in the near future microRNAs could become important therapeutic partners of the immune checkpoint therapy. | [
0.016832798719406128,
0.004339500330388546,
0.00014753651339560747,
0.009563377127051353,
0.0324535071849823,
0.006368697155267,
0.009493071585893631,
0.002785029588267207,
-0.018440740182995796,
0.02277037501335144,
-0.017019713297486305,
0.004429939202964306,
-0.009256499819457531,
0.00887045543640852,
-0.014354710467159748,
-0.02948768436908722,
-0.01528416108340025,
-0.011913285590708256,
0.011381463147699833,
0.04632033407688141,
-0.046820610761642456,
0.0006040963344275951,
0.009370315819978714,
0.018915116786956787,
0.004442035220563412,
0.0006806164747104049,
-0.015453738160431385,
-0.010251494124531746,
-0.01922573521733284,
0.011250772513449192,
-0.025242505595088005,
0.021576274186372757,
0.03290274366736412,
-0.03597698360681534,
-0.008736500516533852,
-0.023363517597317696,
-0.003986775875091553,
0.018455849960446358,
0.054508596658706665,
-0.003896944923326373,
0.013528265058994293,
-0.005723918322473764,
0.00582975335419178,
-0.0019484286895021796,
-0.008710735477507114,
-0.018945422023534775,
-0.006071516778320074,
0.01283830963075161,
-0.014605140313506126,
0.007425817660987377,
0.003287391969934106,
0.015465911477804184,
-0.010187397710978985,
0.004171630833297968,
-0.0061577423475682735,
-0.011061051860451698,
0.017798030748963356,
-0.010138371959328651,
0.004342968575656414,
-0.005167413502931595,
0.007125896867364645,
-0.032470397651195526,
-0.0026191608048975468,
-0.02353842370212078,
-0.004967008717358112,
-0.06639914959669113,
0.008729618042707443,
-0.01753656566143036,
-0.004698891192674637,
0.0015470439102500677,
0.028440074995160103,
0.01933668926358223,
0.003536311909556389,
-0.002714637666940689,
-0.022653618827462196,
-0.03105911985039711,
-0.006375127471983433,
0.011662869714200497,
-0.005346866324543953,
0.025742409750819206,
0.012647436000406742,
0.004133792128413916,
0.009229518473148346,
0.0029229652136564255,
0.0038954864721745253,
0.011295164003968239,
-0.02501744218170643,
0.0035836994647979736,
-0.005616447888314724,
0.014171235263347626,
0.015484057366847992,
-0.006656262092292309,
-0.026722829788923264,
-0.002043588785454631,
0.007310404907912016,
-0.02518288977444172,
0.00023459689691662788,
-0.02895180508494377,
-0.0009425189346075058,
-0.0201692096889019,
-0.024434328079223633,
-0.010641838423907757,
0.010037490166723728,
0.011432821862399578,
0.0019216816872358322,
0.010848462581634521,
0.023980244994163513,
-0.0025468310341238976,
0.010353244841098785,
0.00872904434800148,
-0.030128441751003265,
-0.028104986995458603,
-0.004060509614646435,
0.009313415735960007,
0.0082547627389431,
0.01549256406724453,
0.008172934874892235,
0.00012503564357757568,
0.0064673046581447124,
-0.00606937799602747,
-0.014514820650219917,
0.01635386236011982,
0.006876424886286259,
-0.022613856941461563,
0.01261272095143795,
-0.02669277787208557,
0.015888584777712822,
-0.0012777710799127817,
-0.01713954657316208,
0.0076111964881420135,
-0.0102531211450696,
0.02174650877714157,
-0.025012003257870674,
-0.04680256173014641,
-0.016741611063480377,
-0.004826260264962912,
-0.006462565623223782,
0.0000619976781308651,
0.013550003990530968,
-0.021766413003206253,
-0.007088332436978817,
0.008997537195682526,
0.0026574134826660156,
0.019506270065903664,
0.01473921723663807,
0.013626428321003914,
-0.027221471071243286,
0.00762238958850503,
0.01473818439990282,
0.0023447275161743164,
0.021606044843792915,
0.012383192777633667,
-0.0035781431943178177,
-0.012784264981746674,
0.03732897341251373,
0.029639072716236115,
-0.027851128950715065,
-0.05002204328775406,
-0.014764726161956787,
-0.004919177852571011,
-0.005594267509877682,
0.01041635125875473,
0.0043963040225207806,
0.009589245542883873,
-0.0003354540094733238,
-0.007231700234115124,
-0.008561589755117893,
-0.0049360524863004684,
0.006035767495632172,
0.0045104315504431725,
-0.0040756165981292725,
-0.010369103401899338,
-0.014670119620859623,
0.002527970587834716,
-0.004811270162463188,
-0.008231811225414276,
0.002646437846124172,
0.008069716393947601,
-0.008592385798692703,
0.06634700298309326,
-0.00410561915487051,
0.0240291990339756,
0.044005364179611206,
-0.001253894530236721,
0.00949926022440195,
-0.028289945796132088,
0.010906292125582695,
-0.010972108691930771,
-0.02685905247926712,
-0.019351698458194733,
-0.009147697128355503,
0.03146860748529434,
-0.022421449422836304,
-0.0024023824371397495,
-0.002484165132045746,
0.002417930867522955,
0.001732613891363144,
0.015645481646060944,
0.018527183681726456,
-0.005485714878886938,
0.019074341282248497,
0.030249102041125298,
0.01134592853486538,
-0.010633546859025955,
0.004721709527075291,
-0.004689798224717379,
-0.0030097588896751404,
-0.02758689597249031,
-0.021905671805143356,
0.0024261474609375,
0.010756467469036579,
-0.001585274119861424,
-0.0001728278584778309,
-0.016115380451083183,
0.00920395739376545,
0.004752779379487038,
-0.003971753641963005,
0.01396491564810276,
-0.015981201082468033,
-0.015225604176521301,
0.001544675324112177,
0.010516541078686714,
0.01716356724500656,
0.010645953007042408,
0.008397328667342663,
0.016589181497693062,
0.014250808395445347,
0.015368404798209667,
-0.014995701611042023,
0.006453583482652903,
0.007289070636034012,
-0.01854344829916954,
-0.012645280919969082,
0.03376668691635132,
0.004972710274159908,
-0.03456661477684975,
0.012306857854127884,
-0.017269279807806015,
0.014026233926415443,
-0.013896623626351357,
0.016667794436216354,
-0.004385240375995636,
0.013533373363316059,
-0.013525160029530525,
0.008423300459980965,
-0.01819281280040741,
-0.009825506247580051,
0.014663036912679672,
0.006664113141596317,
-0.0030401856638491154,
0.0075456262566149235,
-0.03500000014901161,
0.0005762912333011627,
-0.018422573804855347,
0.016176283359527588,
0.010102281346917152,
-0.0007868492975831032,
0.00472395122051239,
0.022877248004078865,
-0.022698428481817245,
-0.0011786690447479486,
0.00473563838750124,
-0.026306213811039925,
-0.012361112982034683,
0.009766229428350925,
0.006885727867484093,
0.004158824682235718,
0.012629391625523567,
0.009365725331008434,
-0.006577368825674057,
0.00741545669734478,
-0.008070684969425201,
-0.0012364655267447233,
-0.08105619996786118,
0.003717915853485465,
0.019848523661494255,
-0.02599426358938217,
0.014831116423010826,
-0.024140629917383194,
0.0012656031176447868,
0.016241755336523056,
-0.00713158817961812,
0.004726842977106571,
-0.013638925738632679,
0.020855441689491272,
-0.011669913306832314,
0.009574810042977333,
0.016971927136182785,
-0.01330843847244978,
0.013102753087878227,
-0.01647397130727768,
-0.030236810445785522,
-0.06450791656970978,
-0.0057345242239534855,
-0.010900593362748623,
-0.02393941394984722,
-0.003580027725547552,
-0.020443020388484,
0.002687249332666397,
-0.0042266761884093285,
0.007276683114469051,
-0.019172756001353264,
-0.010354230180382729,
-0.010301274247467518,
-0.024728432297706604,
0.008463623002171516,
0.01493588276207447,
0.04130466654896736,
0.00884369295090437,
-0.006906615104526281,
0.001377392909489572,
-0.00117946183308959,
0.013767989352345467,
-0.001506921835243702,
0.01875755563378334,
0.02450617402791977,
0.02175040915608406,
0.01474079955369234,
0.01660083420574665,
0.015410595573484898,
0.06422440707683563,
0.006677343975752592,
-0.03113039955496788,
-0.0024304548278450966,
-0.01234368234872818,
-0.009130745194852352,
0.018403727561235428,
-0.0066111646592617035,
0.007172476500272751,
-0.037522368133068085,
-0.0036034462973475456,
-0.01541418582201004,
0.0002555760438553989,
0.008029880933463573,
0.008257192559540272,
0.04331145063042641,
0.025116346776485443,
-0.004575840197503567,
-0.021886397153139114,
0.007585683837532997,
-0.02459186129271984,
-0.01578921638429165,
0.019419420510530472,
-0.00016970280557870865,
-0.013578111305832863,
0.002826614771038294,
-0.00945843756198883,
-0.0016630389727652073,
-0.009437434375286102,
-0.008906042203307152,
-0.014854560606181622,
0.014503613114356995,
0.008643675595521927,
0.01564122550189495,
0.004425354767590761,
-0.01999594084918499,
-0.011718766763806343,
-0.026833832263946533,
0.007420481648296118,
0.004991346504539251,
0.012757513672113419,
0.001941625727340579,
-0.015276051126420498,
0.013055871240794659,
-0.0011989434715360403,
-0.0011584581807255745,
0.0062203602865338326,
0.010412517935037613,
-0.036287955939769745,
-0.008553916588425636,
0.007326352875679731,
0.0021457290276885033,
0.009388143196702003,
-0.025546707212924957,
0.009532107040286064,
0.0032075890339910984,
-0.011313769966363907,
-0.01722509041428566,
0.011696833185851574,
-0.006922262720763683,
-0.0033416305668652058,
-0.008359966799616814,
0.0004720297874882817,
0.019969375804066658,
0.0020790291018784046,
-0.01191768329590559,
0.02464757300913334,
-0.00008745369268581271,
-0.016333675011992455,
-0.012143425643444061,
0.0006788722239434719,
0.07187317311763763,
-0.012880966067314148,
0.006040736101567745,
-0.00789483729749918,
-0.003919478505849838,
-0.012585748918354511,
0.005106027238070965,
-0.0019203578121960163,
-0.028652774170041084,
0.006117632612586021,
0.01101718656718731,
-0.02282458171248436,
0.01749320514500141,
0.036274947226047516,
-0.0018470187205821276,
-0.009202014654874802,
0.004365640692412853,
-0.013882901519536972,
0.02198765240609646,
0.005793285556137562,
-0.008342198096215725,
0.007916748523712158,
-0.007857931777834892,
0.0036950353533029556,
-0.00005402415990829468,
-0.001319295377470553,
0.004946241155266762,
-0.014051243662834167,
-0.002105292398482561,
0.004605237394571304,
0.012479523196816444,
0.009901527315378189,
-0.006415967363864183,
0.011824648827314377,
0.00013498170301318169,
-0.010447464883327484,
0.018031595274806023,
-0.008663827553391457,
-0.0016948576085269451,
0.009716115891933441,
0.005096236243844032,
-0.012880057096481323,
0.029529212042689323,
0.012590158730745316,
0.00520309479907155,
0.0001013358123600483,
0.017010483890771866,
-0.009734580293297768,
0.004100508522242308,
-0.002151715802028775,
0.0008309358963742852,
0.003884588135406375,
0.009724677540361881,
-0.02469850331544876,
-0.01745499111711979,
-0.00590975908562541,
0.02722809836268425,
-0.0022868437226861715,
-0.002450827043503523,
-0.001977394102141261,
0.006834515370428562,
0.01800164207816124,
0.02719707414507866,
-0.0019214742351323366,
0.008594006299972534,
-0.00026499805971980095,
-0.011702976189553738,
-0.010840456932783127,
-0.0011661211028695107,
-0.013159163296222687,
-0.03691238537430763,
-0.01129392720758915,
0.004859907552599907,
-0.017663083970546722,
-0.029344433918595314,
-0.01996995508670807,
-0.0188986137509346,
0.025934699922800064,
0.015172802843153477,
0.018505416810512543,
-0.008812671527266502,
-0.0009381258860230446,
-0.015482872724533081,
-0.0038264342583715916,
0.00352175859734416,
-0.020094260573387146,
-0.007447755895555019,
-0.07403059303760529,
-0.04320480674505234,
-0.0012126830406486988,
-0.0049918033182621,
-0.011306481435894966,
0.033881161361932755,
-0.01921805553138256,
0.01743629015982151,
-0.005212872289121151,
-0.006779549643397331,
-0.018564697355031967,
0.0293441005051136,
0.030082987621426582,
-0.007425354328006506,
0.010302339680492878,
0.007485290989279747,
0.012839386239647865,
-0.0022989849094301462,
-0.017113015055656433,
-0.0018722228705883026,
-0.029806647449731827,
0.0029632323421537876,
-0.03289599344134331,
0.008156471885740757,
-0.0004201123956590891,
-0.08096792548894882,
-0.0247485488653183,
0.02638009935617447,
-0.04692643880844116,
-0.028492432087659836,
0.014559924602508545,
0.026674481108784676,
-0.015843497589230537,
-0.02904963679611683,
-0.01789669319987297,
-0.01773686520755291,
0.02317485213279724,
-0.003909034188836813,
0.00504636624827981,
0.008028415031731129,
-0.005974016152322292,
0.016456210985779762,
0.003058763686567545,
0.0116750318557024,
0.020781569182872772,
-0.016274264082312584,
0.01667838729918003,
-0.010905370116233826,
0.00027484074234962463,
-0.00835567805916071,
-0.031046545132994652,
-0.011988071724772453,
0.01994125172495842,
-0.009098483249545097,
0.0039042276330292225,
-0.017512310296297073,
-0.013814790174365044,
-0.000009233597666025162,
-0.02269335836172104,
-0.0030606472864747047,
-0.016300980001688004,
-0.0026566502638161182,
0.0004728905623778701,
-0.017726562917232513,
-0.019193030893802643,
-0.010424786247313023,
0.011070665903389454,
-0.02208857052028179,
0.020045410841703415,
0.01099909096956253,
0.015028578229248524,
0.00920846313238144,
-0.002503008581697941,
0.012109555304050446,
-0.02428598701953888,
0.006714562885463238,
0.022079404443502426,
-0.01781141757965088,
-0.01400362141430378,
0.020338188856840134,
0.0031064602080732584,
-0.00805635191500187,
0.007803156040608883,
0.010830397717654705,
0.024065177887678146,
0.001107414485886693,
0.000015072524547576904,
0.0020035183988511562,
0.07154287397861481,
-0.004789730068296194,
0.028172515332698822,
-0.035833440721035004,
0.0037498038727790117,
0.0047102198004722595,
-0.0067550186067819595,
0.0019082091748714447,
-0.004630252718925476,
-0.001387361204251647,
0.01406647078692913,
-0.01029666606336832,
-0.001911600586026907,
0.01261200848966837,
-0.044192761182785034,
0.018217697739601135,
-0.011527106165885925,
-0.006376427598297596,
0.030430343002080917,
0.0069320835173130035,
-0.006837855093181133,
-0.01626087725162506,
-0.00858251377940178,
-0.06417179852724075,
-0.01334362756460905,
0.002884957008063793,
-0.032608382403850555,
-0.006806729361414909,
-0.03408290445804596,
0.026733195409178734,
0.0082825543358922,
0.014841353520751,
0.0020619553979486227,
0.01980174332857132,
0.003503230167552829,
-0.004230521619319916,
-0.027976367622613907,
0.007121131289750338,
-0.027658872306346893,
-0.019378697499632835,
0.029020875692367554,
-0.015525685623288155,
0.004080194979906082,
-0.0014539218973368406,
0.003966578748077154,
0.03168998658657074,
-0.0016902150819078088,
-0.0029752678237855434,
0.02162836492061615,
0.00819894578307867,
-0.00572927575558424,
-0.0072348094545304775,
0.01635897345840931,
-0.019264616072177887,
-0.0026550088077783585,
-0.027735112234950066,
-0.014293225482106209,
0.012959299609065056,
-0.006806942168623209,
-0.011161231435835361,
0.012217540293931961,
-0.015383240766823292,
-0.010743079707026482,
-0.013766005635261536,
0.032218169420957565,
-0.00812320876866579,
-0.0014499577227979898,
-0.015063038095831871,
0.0024235453456640244,
0.01764984242618084,
-0.02036506123840809,
0.0001726299524307251,
0.00587514229118824,
0.0038335034623742104,
0.04303371161222458,
0.011662926524877548,
0.008412551134824753,
-0.024866096675395966,
0.01156580913811922,
0.012661278247833252,
-0.014784923754632473,
0.028067434206604958,
-0.0036619415041059256,
-0.03580688312649727,
-0.025529127568006516,
0.006502809468656778,
0.009077519178390503,
0.005941301118582487,
-0.0025762913282960653,
0.011450376361608505,
-0.0033232374116778374,
0.019910946488380432,
0.006228117272257805,
-0.009251824580132961,
0.003590142587199807,
0.033515337854623795,
0.004131889436393976,
0.009787345305085182,
-0.013148179277777672,
0.03779313340783119,
0.008084588684141636,
0.014508090913295746,
-0.022070514038205147,
0.020856481045484543,
-0.0013190689496695995,
-0.00002934969961643219,
0.0232856422662735,
0.010363738983869553,
0.0022976743057370186,
0.0041427332907915115,
0.024189405143260956,
0.005374077241867781,
0.004923900123685598,
0.026938971132040024,
0.00010842597112059593,
0.024354081600904465,
-0.007156191393733025,
0.013427630066871643,
0.010171541944146156,
-0.014418460428714752,
0.01418446283787489,
-0.00473879836499691,
0.0023778919130563736,
-0.015222989022731781,
-0.0003611977444961667,
-0.006898126099258661,
-0.013800662010908127,
0.0007837205193936825,
-0.004939048085361719,
0.004120310768485069,
0.012812714092433453,
0.03546629101037979,
0.002380009973421693,
-0.01388406753540039,
0.006953468546271324,
0.0056201983243227005,
0.0026954335626214743,
0.0070549314841628075,
0.01412927359342575,
0.016093268990516663,
-0.025529511272907257,
-0.02476530149579048,
0.0022825945634394884,
-0.005911198910325766,
0.00936749018728733,
0.007302707992494106,
0.013043494895100594,
0.00903637707233429,
-0.0012296568602323532,
0.02979763224720955,
-0.0002207999350503087,
0.004921841900795698,
0.004283531568944454,
-0.0060442364774644375,
-0.009856467135250568,
0.012260371819138527,
0.003708193078637123,
0.017400601878762245,
-0.010145436972379684,
-0.0034844442270696163,
0.011088652536273003,
0.04183372110128403,
0.026358118280768394,
-0.006768468767404556,
-0.005987218581140041,
0.011288282461464405,
0.010512446984648705,
0.002389803994446993,
0.0010801225434988737,
-0.022570226341485977,
0.0213239137083292,
-0.02138538844883442,
0.00790245272219181,
0.02200842648744583,
0.0024674716405570507,
-0.003653621533885598,
-0.02549343928694725,
-0.014031445607542992,
0.01083550974726677,
0.0067497664131224155,
0.006965469568967819,
-0.044135428965091705,
0.005391367711126804,
-0.010907653719186783,
-0.0009456342086195946,
0.006253408268094063,
-0.0050369384698569775,
0.0134725421667099,
0.0031205574050545692,
0.008214019238948822,
0.0022733178921043873,
0.0030045541934669018,
-0.01961475983262062,
0.010687833651900291,
0.01138659380376339,
-0.014634594321250916,
-0.026537729427218437,
-0.025978419929742813,
0.02371721900999546,
0.006243509240448475,
-0.009005414322018623,
-0.018738433718681335
] | [
0.23646901547908783,
-0.25603193044662476,
0.19956840574741364,
-0.18448926508426666,
0.021341558545827866,
-0.5160588026046753,
0.4172815978527069,
-0.3142956793308258,
-0.010661628097295761,
-0.5730187296867371,
0.42157185077667236,
0.17103278636932373,
-0.8584652543067932,
0.27894923090934753,
-0.02300150692462921,
0.5063247084617615,
0.5082076191902161,
0.3475731611251831,
-0.3421790301799774,
-0.4376712143421173,
-0.3241690993309021,
0.06698659807443619,
0.6782931685447693,
-0.1380358636379242,
0.30362677574157715,
0.13063162565231323,
0.5906031727790833,
-0.273965448141098,
0.27837616205215454,
-0.17678311467170715,
0.14687849581241608,
0.4095025062561035,
-0.36926060914993286,
0.0431889183819294,
-0.011431513354182243,
0.19974161684513092,
-0.4040023684501648,
0.27991601824760437,
-0.2423095703125,
-0.32154184579849243,
-0.4332742989063263,
-0.3681255877017975,
-0.6444140076637268,
0.5253340005874634,
0.053408894687891006,
-0.27422595024108887,
-1.2252825498580933,
0.8140844702720642,
-0.3052070140838623,
-0.2737785577774048,
0.043494679033756256,
0.0684112012386322,
0.34528493881225586,
0.1598920226097107,
0.5583477020263672,
-0.013078263029456139,
-0.6189660429954529,
-0.3664545714855194,
0.3656880259513855,
-0.13525445759296417,
0.22966662049293518,
0.1237802729010582,
-0.5744651556015015,
0.24831946194171906,
-0.034958723932504654,
0.6124841570854187,
0.12379211187362671,
-0.3941100835800171,
-0.22182190418243408,
-0.3799035847187042,
0.05726437270641327,
-0.4415898323059082,
-0.194453626871109,
0.10403585433959961,
0.10338979959487915,
-0.49581897258758545,
0.11388150602579117,
-0.44370290637016296,
-0.1487654447555542,
-0.10089810937643051,
-0.030410386621952057,
0.10720808058977127,
-0.19330984354019165,
-0.2027156949043274,
0.5275427103042603,
0.049550432711839676,
-0.4166705310344696,
0.8729102611541748,
-0.6427919268608093,
-0.28718918561935425,
0.08824224770069122,
0.017097141593694687,
0.35441499948501587,
0.31226351857185364,
0.33870506286621094,
-0.024871278554201126,
-0.24996361136436462,
-0.034536413848400116,
0.022050542756915092,
0.3867819011211395,
-0.18099789321422577,
0.11662355065345764,
-0.012362467125058174,
-0.5898391008377075,
-0.31825777888298035,
-0.3726259469985962,
-0.13641124963760376,
-0.7104355096817017,
-0.7323604226112366,
0.16478870809078217,
-0.2686707377433777,
0.16016516089439392,
-0.13604196906089783,
-0.27799367904663086,
-0.285031795501709,
0.3884669840335846,
0.10631299763917923,
-0.2120247632265091,
-0.03194326534867287,
0.3798285722732544,
0.013030328787863255,
1.8112071752548218,
-0.2262764275074005,
0.5873970985412598,
-0.04437216743826866,
-0.20386499166488647,
0.2960446774959564,
-0.12958168983459473,
-0.3327018618583679,
0.6583368182182312,
0.05332883074879646,
0.9746848344802856,
-0.7265937924385071,
0.15378761291503906,
0.017258599400520325,
-0.028576143085956573,
0.009565130807459354,
0.005791177973151207,
0.4284287393093109,
-0.04241558909416199,
-0.35455045104026794,
-0.541214644908905,
0.03269276022911072,
-0.1294151246547699,
-0.008849512785673141,
-0.33783984184265137,
0.04861888661980629,
-0.2085275501012802,
0.06316877901554108,
0.06946148723363876,
-0.17972432076931,
-0.24586579203605652,
-0.729371964931488,
0.33921390771865845,
-0.24279630184173584,
0.20371508598327637,
0.20322808623313904,
0.06076313555240631,
-0.00558951823040843,
0.36588308215141296,
0.0002222122420789674,
-0.4458475708961487,
-0.4262194037437439,
-0.011552629061043262,
0.6475668549537659,
-0.4672418534755707,
0.34290647506713867,
0.5902032852172852,
0.33594101667404175,
-0.3730296194553375,
-0.5250648260116577,
-0.49329546093940735,
-0.15508884191513062,
-0.8120158314704895,
-0.023718060925602913,
-0.3996724486351013,
0.482289582490921,
-0.22070495784282684,
-0.00023151305504143238,
0.2087392508983612,
-0.8305701613426208,
-0.389758825302124,
-0.244897723197937,
-0.47366267442703247,
0.6602692604064941,
0.4248509407043457,
0.46102502942085266,
0.13079974055290222,
-0.0678284540772438,
0.06931180506944656,
0.01648939773440361,
0.1307324469089508,
0.4791780710220337,
-0.8486669063568115,
1.410040020942688,
-0.03696830943226814,
-0.1514768898487091,
1.9755319356918335,
-0.07266946882009506,
-0.1605023443698883,
-0.4005030691623688,
0.11003986746072769,
0.6405695676803589,
-0.5022194981575012,
-0.45633646845817566,
-0.0371074303984642,
0.1475733071565628,
-0.15855054557323456,
0.044570356607437134,
0.1868121474981308,
0.6336072087287903,
-0.4075588583946228,
-0.0989265963435173,
-0.22842584550380707,
0.22790849208831787,
-0.44269371032714844,
-0.14306220412254333,
0.23043103516101837,
-0.59926837682724,
0.41248947381973267,
0.3111213743686676,
-0.836007297039032,
0.435735285282135,
1.5875173807144165,
-0.003252674825489521,
0.6388405561447144,
0.3001549541950226,
-0.02529788389801979,
0.6373071074485779,
-0.08349611610174179,
0.5732740163803101,
-0.8793250322341919,
0.4642278850078583,
-0.40548357367515564,
0.08617807179689407,
0.30715298652648926,
0.14766839146614075,
-0.11893843859434128,
-0.14868220686912537,
-0.08792482316493988,
0.016369765624403954,
0.5295445919036865,
-0.6982136368751526,
0.014340070076286793,
0.1787448674440384,
-0.4186522662639618,
-0.10867404192686081,
-0.17572832107543945,
-0.7467807531356812,
-0.13684654235839844,
0.2717450261116028,
0.013207306154072285,
0.4538922905921936,
-1.13760244846344,
0.2892399728298187,
0.39718708395957947,
-0.2734738886356354,
-0.2833707332611084,
0.15297168493270874,
-0.384436696767807,
-0.43954429030418396,
0.008246209472417831,
0.0866415798664093,
0.17284710705280304,
-0.2453661859035492,
-0.19086822867393494,
-0.19813953340053558,
-0.22714659571647644,
0.960865318775177,
0.6440741419792175,
0.8833739757537842,
0.28909429907798767,
-0.62270188331604,
-0.05874526500701904,
-0.15038858354091644,
-0.7342599630355835,
0.23793454468250275,
1.1987696886062622,
-0.35261911153793335,
0.011707344092428684,
-0.00582980178296566,
0.47618862986564636,
0.7822214365005493,
-0.5135720372200012,
-0.549508273601532,
-0.2733808159828186,
0.009432279504835606,
-0.5985448360443115,
-0.7773328423500061,
0.2947467863559723,
-0.13001090288162231,
0.3549529016017914,
-0.8530365824699402,
0.21621009707450867,
0.10059182345867157,
0.2945380210876465,
-0.22071120142936707,
0.43045568466186523,
0.6946967244148254,
-0.13419200479984283,
0.046062715351581573,
-0.013384910300374031,
-0.3387289047241211,
0.13885171711444855,
-0.28658783435821533,
-0.1695805937051773,
-0.45708760619163513,
0.3788934350013733,
-5.516873836517334,
-0.1468771994113922,
-0.03334615379571915,
0.13180142641067505,
-0.34299466013908386,
-0.06448476761579514,
1.0680742263793945,
0.024043167009949684,
0.6742063164710999,
0.3305920660495758,
0.5028485655784607,
0.41463449597358704,
0.1265200972557068,
-0.030008843168616295,
-0.14597298204898834,
0.1437910944223404,
0.043779727071523666,
-0.30288535356521606,
0.7288303971290588,
0.058560941368341446,
0.6027131080627441,
-0.12598291039466858,
0.056176137179136276,
0.6646190285682678,
-0.2218266874551773,
-0.1726960986852646,
-1.0763591527938843,
0.35819190740585327,
0.1301536113023758,
-0.3288883864879608,
0.1437819004058838,
-0.5812702775001526,
0.13670562207698822,
-0.5551839470863342,
0.38744425773620605,
-0.09137628227472305,
-0.018950456753373146,
0.14602288603782654,
-0.06233767792582512,
-0.37784793972969055,
0.5698950886726379,
0.25594788789749146,
-0.12713371217250824,
-0.06429264694452286,
0.17622606456279755,
-0.11531058698892593,
0.029246767982840538,
0.45298007130622864,
-0.3284457325935364,
0.7980231046676636,
-0.18591539561748505,
-0.2750839293003082,
0.5240483283996582,
0.5594459772109985,
0.3922385275363922,
-0.44729048013687134,
-0.355812132358551,
-0.1976541131734848,
-0.5706446766853333,
0.34263429045677185,
-0.7840220928192139,
-0.09483446925878525,
-0.1772918552160263,
-0.4792003631591797,
0.3694838285446167,
0.3862072229385376,
-0.6587409973144531,
-0.8903325200080872,
0.47060176730155945,
0.0008734525763429701,
-0.37146803736686707,
0.3791947364807129,
0.28342828154563904,
-0.5435327291488647,
0.5774770975112915,
0.13301703333854675,
0.5990138649940491,
0.017293933779001236,
-0.03871830552816391,
0.08832084387540817,
-0.4695979058742523,
0.13260720670223236,
-0.22473929822444916,
-0.15170374512672424,
0.7497431039810181,
-0.754267156124115,
-0.07347243279218674,
-0.10856061428785324,
-0.6785325407981873,
0.26186051964759827,
0.6176749467849731,
-0.17658746242523193,
0.3269753158092499,
0.29303961992263794,
0.4469040036201477,
0.1353881061077118,
-0.09993322938680649,
0.5027953386306763,
0.6388725638389587,
0.1299281120300293,
1.093066930770874,
0.23220303654670715,
-0.22543488442897797,
-1.2576055526733398,
-0.08762452006340027,
0.1344786286354065,
-0.5879123210906982,
0.004556456580758095,
0.44934770464897156,
-0.7608494162559509,
-0.26395899057388306,
0.09248746186494827,
-0.48151788115501404,
0.16712477803230286,
0.4468251168727875,
-0.5619859099388123,
-0.22375702857971191,
-0.09140771627426147,
0.4003308117389679,
-0.34765419363975525,
0.19037339091300964,
0.5531905889511108,
-0.3091476261615753,
0.46608686447143555,
0.050055041909217834,
-0.4676705002784729,
0.03774713724851608,
0.5912108421325684,
-0.40835097432136536,
-0.035648588091135025,
0.6231443285942078,
0.7158253192901611,
-0.9422205686569214,
-0.3459664285182953,
0.1353568583726883,
-0.383231520652771,
-0.6335743069648743,
0.3318338692188263,
0.10135676711797714,
-0.10296788811683655,
0.16264289617538452,
-0.4235211908817291,
0.15630002319812775,
0.01474554929882288,
0.06548194587230682,
0.06050259247422218,
0.24668748676776886,
0.021883336827158928,
-0.16711343824863434,
-0.15001218020915985,
-0.10417260974645615,
0.3538082242012024,
-0.0426165945827961,
-0.22500598430633545,
-0.07250918447971344,
0.505858838558197,
1.057438850402832,
-0.16491466760635376,
0.4720573425292969,
-0.6192951202392578,
0.09025907516479492,
0.4839470386505127,
-0.8296465873718262,
0.4746640920639038,
-0.4184480309486389,
-0.1333741396665573,
-0.5177870392799377,
-0.10937561094760895,
-0.003580349264666438,
0.0964650809764862,
-0.45086076855659485,
-0.19686664640903473,
-0.18372035026550293,
-0.4200214147567749,
0.10131024569272995,
0.14647726714611053,
-0.32612624764442444,
0.19473965466022491,
-0.37228524684906006,
-0.12355035543441772,
0.38553640246391296,
-0.8998246788978577,
-0.38759517669677734,
0.4809541404247284,
0.38802143931388855,
-0.3168517053127289,
0.11594319343566895,
-0.22206063568592072,
-0.2649632692337036,
-0.5169399380683899,
0.5016754269599915,
0.1636686474084854,
0.2180703580379486,
-0.6053380370140076,
0.1615302711725235,
-0.36185508966445923,
-0.03063737042248249,
0.7088013887405396,
-0.2914663255214691,
-0.9703571200370789,
0.24289721250534058,
0.7462549209594727,
-0.3363479971885681,
0.5598278045654297,
0.05740265175700188,
0.266164094209671,
-0.585254430770874,
0.21141460537910461,
0.14747931063175201,
-0.15045581758022308,
-0.6036377549171448,
-0.5676376819610596,
0.5775540471076965,
0.4203447997570038,
-0.28070560097694397,
0.16668382287025452,
-0.2453407347202301,
-0.07480691373348236,
-0.031850311905145645,
0.2750815451145172,
0.20915864408016205,
-0.31171005964279175,
0.1649465262889862,
0.06319770216941833,
-0.5892996788024902,
0.19978174567222595,
0.3809798061847687,
-0.7791992425918579,
-0.14878134429454803,
0.17193228006362915,
0.21439112722873688,
-0.34380942583084106,
-0.22378893196582794,
-0.1786193698644638,
-0.28028538823127747,
-0.47489842772483826,
-0.3001558482646942,
0.3531210720539093,
0.1551087349653244,
0.7464844584465027,
0.14184942841529846,
0.323690265417099,
-0.43006065487861633,
-0.16796931624412537,
-0.019473707303404808,
0.38524454832077026,
0.42755457758903503,
-0.5201042890548706,
-0.7138410806655884,
0.10835784673690796,
0.06393221765756607,
-0.053988732397556305,
0.09372571855783463,
0.41050484776496887,
1.4028232097625732,
0.21929612755775452,
0.020469091832637787,
-0.1196112260222435,
-0.25790825486183167,
0.02002863585948944,
-0.41576287150382996,
0.10436785221099854,
-0.5872142314910889,
-0.30439329147338867,
0.13829836249351501,
-0.19716832041740417,
-0.08972830325365067,
-0.98116534948349,
0.3796153962612152,
-0.11007623374462128,
-0.22275374829769135,
-0.5194618701934814,
0.810188353061676,
0.6590647101402283,
-0.28716525435447693,
0.5669289827346802,
-0.21343722939491272,
0.21185649931430817,
-0.2134091705083847,
0.28445255756378174,
-0.33268219232559204,
-0.6025625467300415,
0.2068072110414505,
-0.6451225876808167,
0.4868561625480652,
-1.0972647666931152,
0.09811758249998093,
-0.40416452288627625,
0.20426838099956512,
-0.48817217350006104,
-0.12767226994037628,
-0.10792163014411926,
-0.6517463326454163,
-0.1661738157272339,
-0.040566008538007736,
0.2410777509212494,
-0.1399773359298706,
0.13291297852993011,
-0.1546122133731842,
-0.34319424629211426,
-0.5768028497695923,
0.32851627469062805,
0.3545573949813843,
-0.2911601662635803,
-0.2091025859117508,
0.38718271255493164,
0.5402581691741943,
0.3878268897533417,
-0.5999659895896912,
0.06538461893796921,
-0.346381276845932,
-0.226651132106781,
0.7667115926742554,
0.41716280579566956,
-0.6938298344612122,
0.46334853768348694,
-0.2242400050163269,
-0.0679459348320961,
0.5137096047401428,
-0.2660355865955353,
0.16415473818778992,
0.5342061519622803,
0.5455160140991211,
0.018423568457365036,
-0.55665123462677,
0.5537541508674622,
0.11571785062551498,
0.017093833535909653,
-0.5665380954742432,
0.6257815957069397,
0.5888176560401917,
0.4218713641166687,
-0.3143466114997864,
0.4565504789352417,
0.2803862988948822,
0.1640641689300537,
0.2016894519329071,
-0.25780588388442993,
-0.4098148047924042,
-0.05090386047959328,
0.4508388936519623,
0.22171445190906525,
-0.579298734664917,
0.18622538447380066,
0.5075071454048157,
0.5318675637245178,
0.49533015489578247,
0.28866979479789734,
-0.23345720767974854,
0.14015017449855804,
0.2698349952697754,
-0.24259038269519806,
-0.2851542532444,
0.2435021698474884,
-0.5043792128562927,
0.06920823454856873,
0.8756746053695679,
-0.5662965774536133,
-0.046636611223220825,
0.16726550459861755,
0.06263259053230286,
-0.209360733628273,
-0.214199036359787,
0.8724147081375122,
-0.3863202631473541,
0.1834098845720291,
0.563476026058197,
-0.10864315927028656,
0.26947617530822754,
-0.17944137752056122,
0.21286369860172272,
-0.15130075812339783,
0.03584698587656021,
0.5917076468467712,
0.10616427659988403,
-0.5700957179069519,
-0.09782519936561584,
-0.0020494807977229357,
-0.03416876494884491,
0.3610190749168396,
0.02789068967103958,
0.43913164734840393,
-0.08639398217201233,
-1.0621734857559204,
-0.49812281131744385,
-0.27707794308662415,
-0.4940545856952667,
-0.032748736441135406,
0.1611601859331131,
-0.02498829923570156,
0.47263002395629883,
-0.29174351692199707,
-0.1708008348941803,
0.23566599190235138,
-0.021125290542840958,
-0.04550137743353844,
0.15398438274860382,
0.5779929757118225,
0.013950883410871029,
0.4518725574016571,
0.19199542701244354,
0.5401437282562256,
0.010987409390509129,
0.6789933443069458,
-0.7957135438919067,
0.7023599147796631,
-0.6013230085372925,
-0.2998962998390198,
-0.4528581202030182,
-0.03887977451086044,
1.0210959911346436,
0.4394243657588959,
-0.04484418407082558,
0.08950699120759964,
0.3344706594944,
0.16981221735477448,
0.1928161382675171,
-0.6552976369857788,
0.055020201951265335,
-0.5616229772567749,
-0.017087571322917938,
-0.32613620162010193,
0.48641619086265564,
-0.04042309150099754,
-0.6976024508476257,
-0.05612621456384659,
0.7703295350074768,
0.26048585772514343,
0.03491997346282005,
0.3929987847805023,
-0.150441974401474,
-0.3292771279811859,
-0.6706802845001221,
0.44138652086257935,
-0.2484472244977951,
-0.13560238480567932,
-0.4133818745613098,
0.2187773585319519,
0.32426169514656067,
0.11834929883480072,
0.1656356006860733,
0.08219194412231445,
0.2052738219499588,
0.1991501748561859,
-0.0006572272395715117,
-0.1262579709291458,
-0.3249727785587311,
-0.815200924873352,
-0.702608048915863,
0.4862992465496063,
0.24155758321285248,
-0.40923431515693665,
-0.4394776225090027,
0.541612982749939,
0.02520284429192543,
0.15955369174480438,
-0.17924365401268005,
-0.6111406683921814,
-0.38460713624954224,
0.11789419502019882
] |
Fibrosis is a pathological result of a dysfunctional repair response to tissue injury and occurs in a number of organs, including the lungs1. Cellular metabolism regulates tissue repair and remodelling responses to injury2-4. AMPK is a critical sensor of cellular bioenergetics and controls the switch from anabolic to catabolic metabolism5. However, the role of AMPK in fibrosis is not well understood. Here, we demonstrate that in humans with idiopathic pulmonary fibrosis (IPF) and in an experimental mouse model of lung fibrosis, AMPK activity is lower in fibrotic regions associated with metabolically active and apoptosis-resistant myofibroblasts. Pharmacological activation of AMPK in myofibroblasts from lungs of humans with IPF display lower fibrotic activity, along with enhanced mitochondrial biogenesis and normalization of sensitivity to apoptosis. In a bleomycin model of lung fibrosis in mice, metformin therapeutically accelerates the resolution of well-established fibrosis in an AMPK-dependent manner. These studies implicate deficient AMPK activation in non-resolving, pathologic fibrotic processes, and support a role for metformin (or other AMPK activators) to reverse established fibrosis by facilitating deactivation and apoptosis of myofibroblasts. | [
-0.012178533710539341,
0.00936385802924633,
-0.006103802938014269,
0.012880690395832062,
-0.014696571044623852,
-0.020217202603816986,
0.01063479296863079,
0.02171364426612854,
-0.007012919057160616,
0.0008397302590310574,
-0.03136323392391205,
0.009023742750287056,
-0.017716728150844574,
0.02654024213552475,
-0.018263069912791252,
0.030174732208251953,
-0.005464722402393818,
0.009250396862626076,
0.004804825410246849,
-0.020447513088583946,
-0.006263193674385548,
0.0020237164571881294,
0.009596487507224083,
0.008439474739134312,
0.018236201256513596,
0.0065267495810985565,
0.013992241583764553,
-0.009575406089425087,
-0.0032147374004125595,
0.02622697502374649,
-0.017315097153186798,
0.00016090768622234464,
0.022525329142808914,
-0.005702855996787548,
0.0015076546696946025,
0.011000491678714752,
-0.0032834913581609726,
0.008527744561433792,
-0.010041831061244011,
-0.003374934196472168,
-0.002679510973393917,
-0.001292567583732307,
0.0061413561925292015,
0.008151426911354065,
-0.00776437483727932,
0.018063783645629883,
0.00661122240126133,
-0.008969040587544441,
-0.03393809124827385,
0.011027466505765915,
-0.023306161165237427,
-0.02521265111863613,
-0.008975987322628498,
0.00999412126839161,
-0.006056272424757481,
-0.0013595116324722767,
0.016772687435150146,
-0.0430581234395504,
0.010542386211454868,
-0.0164811871945858,
0.0156995952129364,
-0.0050384243950247765,
-0.010200840421020985,
-0.04013834148645401,
0.010651953518390656,
-0.06738850474357605,
0.015835942700505257,
0.01711912825703621,
0.00625162199139595,
-0.02703295834362507,
-0.004376665689051151,
0.006427036132663488,
0.007315920665860176,
-0.03495068848133087,
0.011176161468029022,
-0.05925726890563965,
0.0036080959253013134,
0.02908140793442726,
0.022318650037050247,
0.031381119042634964,
-0.01554221659898758,
-0.018812423571944237,
0.030128974467515945,
0.019165873527526855,
-0.011770209297537804,
0.003003882011398673,
-0.014649322256445885,
-0.005744529888033867,
-0.010595064610242844,
-0.003840409917756915,
-0.005734642036259174,
-0.019844206050038338,
0.012301761656999588,
-0.008224784396588802,
0.021549126133322716,
0.02649487368762493,
-0.025576326996088028,
0.0034003471955657005,
0.017997533082962036,
0.0304412879049778,
-0.014635063707828522,
0.02081421948969364,
0.00922881718724966,
-0.018428947776556015,
0.025265425443649292,
0.006961984094232321,
0.012761596590280533,
-0.018180547282099724,
0.016535915434360504,
0.016768110916018486,
-0.0319010429084301,
0.015640661120414734,
-0.007246674038469791,
0.012473853304982185,
0.0015377132222056389,
-0.01605815626680851,
-0.013151587918400764,
0.006433412432670593,
0.019682791084051132,
0.011763251386582851,
0.014452243223786354,
0.02026815339922905,
0.008336558938026428,
0.019214291125535965,
0.005050229374319315,
-0.010523006319999695,
-0.001022540032863617,
0.02839669957756996,
-0.013186098076403141,
-0.004080740734934807,
-0.006964067928493023,
0.015944261103868484,
0.018198056146502495,
-0.0003112785052508116,
0.025712937116622925,
0.003446798538789153,
-0.010084780864417553,
-0.01238336507230997,
-0.007500556763261557,
-0.022500408813357353,
0.004100339487195015,
0.0021645063534379005,
0.006602824665606022,
0.014737952500581741,
0.01507532224059105,
0.004542392212897539,
0.019413042813539505,
0.010033559054136276,
-0.002541197929531336,
0.007780620828270912,
-0.0034635011106729507,
-0.0005314033478498459,
-0.013962149620056152,
-0.019464701414108276,
-0.0065422686748206615,
0.009637380950152874,
-0.013730349019169807,
-0.022924207150936127,
0.007860999554395676,
0.00538092665374279,
-0.031505610793828964,
-0.007390551269054413,
0.004862978123128414,
0.007851612754166126,
0.03741781786084175,
-0.0245074350386858,
0.01579861529171467,
-0.019457336515188217,
-0.017004195600748062,
0.008520379662513733,
-0.010344813577830791,
-0.019400404766201973,
-0.005826934240758419,
0.006054186262190342,
0.021656662225723267,
-0.006581161171197891,
-0.00860966183245182,
0.010558638721704483,
-0.011429734528064728,
0.06699278950691223,
0.03336448222398758,
0.008381998166441917,
0.0032925549894571304,
0.006509149447083473,
0.0036621761973947287,
-0.016064122319221497,
-0.011819257400929928,
-0.01025210041552782,
0.010024584829807281,
0.013306332752108574,
0.0022965804673731327,
-0.034317366778850555,
-0.02062232792377472,
0.03576385974884033,
0.0029262444004416466,
0.00451809074729681,
0.012504889629781246,
0.006163128186017275,
-0.0032326385844498873,
-0.0068160006776452065,
0.018337728455662727,
-0.011755397543311119,
0.02193829044699669,
-0.006641211453825235,
0.003224794752895832,
0.014279212802648544,
0.012071099132299423,
-0.015584948472678661,
0.0008106986060738564,
0.013531235978007317,
0.010612158104777336,
-0.002886157715693116,
-0.007375871296972036,
-0.00015068077482283115,
0.008527949452400208,
0.0079151326790452,
-0.02588503621518612,
0.01721991039812565,
0.0013265545712783933,
-0.013346110470592976,
0.001401066081598401,
0.013032360933721066,
-0.005980867426842451,
0.00193642673548311,
-0.00036331312730908394,
0.007415289990603924,
-0.008649526163935661,
0.014254683628678322,
-0.030238213017582893,
0.022358408197760582,
-0.0015559005551040173,
-0.015994686633348465,
-0.010426492430269718,
-0.030451571568846703,
0.024446003139019012,
-0.022076860070228577,
0.010790843516588211,
-0.028350425884127617,
0.016640493646264076,
-0.01257931999862194,
0.01118452474474907,
0.0010266238823533058,
0.00712536321952939,
-0.01492750272154808,
-0.0070762718096375465,
0.002021013991907239,
0.007741778623312712,
-0.01303494069725275,
-0.003523118095472455,
-0.021250002086162567,
0.005883407313376665,
0.0003300850512459874,
0.008766120299696922,
-0.019584864377975464,
0.010145312175154686,
-0.03309790790081024,
-0.007222631946206093,
-0.00750343594700098,
0.024232149124145508,
0.0005978055996820331,
-0.0022384440526366234,
0.008578325621783733,
-0.0031114094890654087,
0.00964344758540392,
-0.014911985024809837,
-0.010142717510461807,
0.008975891396403313,
0.013656535185873508,
-0.008204327896237373,
0.0011024679988622665,
0.005328045692294836,
-0.005836696829646826,
-0.004050015471875668,
-0.08169400691986084,
-0.01728590577840805,
-0.02186756581068039,
0.010880737565457821,
0.004281823523342609,
0.032094504684209824,
0.00033974903635680676,
-0.021293088793754578,
-0.0127619169652462,
0.004131144378334284,
-0.004821701440960169,
-0.03461194038391113,
-0.006542846094816923,
0.0037175577599555254,
-0.031148597598075867,
-0.010410793125629425,
0.016112904995679855,
-0.0019506476819515228,
0.007807486690580845,
-0.016592005267739296,
0.006572720594704151,
0.007480076048523188,
-0.008373886346817017,
-0.003451358526945114,
-0.0022035965230315924,
-0.022238846868276596,
0.015314599499106407,
-0.021914873272180557,
-0.005439568776637316,
0.020683884620666504,
-0.030672457069158554,
0.009069221094250679,
-0.006929820403456688,
0.0025076461024582386,
-0.011373949237167835,
-0.004136739298701286,
-0.00204719346947968,
0.007207482121884823,
-0.02992945909500122,
0.00043330201879143715,
-0.01922217383980751,
0.017073560506105423,
0.0012561442563310266,
-0.0013577204663306475,
0.0015432970831170678,
0.004271983169019222,
0.0029735800344496965,
-0.00913776084780693,
0.013619799166917801,
-0.0032790224067866802,
0.0023867979180067778,
-0.0031411941163241863,
-0.004186679609119892,
0.015211932361125946,
-0.014217546209692955,
-0.004065573215484619,
0.005444086156785488,
0.03042832762002945,
-0.012432416900992393,
-0.0077133201994001865,
0.0012905234470963478,
-0.015524409711360931,
-0.018465321511030197,
0.030015978962183,
0.016087625175714493,
-0.005089142359793186,
0.01709023118019104,
-0.005719747394323349,
0.003862227313220501,
0.011919098906219006,
-0.001249214168637991,
0.02561138942837715,
-0.014951823279261589,
-0.0040547507815063,
-0.014962056651711464,
-0.013731198385357857,
-0.009680485352873802,
-0.003613455221056938,
0.006400640122592449,
-0.008794764056801796,
-0.02433568239212036,
0.010563796386122704,
-0.007639412302523851,
-0.001723972149193287,
-0.018968593329191208,
-0.012818938121199608,
0.0045203580521047115,
0.040525078773498535,
0.016023507341742516,
-0.011777816340327263,
-0.0010566397104412317,
0.02512967586517334,
-0.010723643004894257,
0.008440441451966763,
0.018579751253128052,
-0.008893758989870548,
-0.007156989071518183,
-0.010641226544976234,
0.012632232159376144,
0.007988213561475277,
-0.02237822487950325,
0.015235433354973793,
0.009393119253218174,
-0.010621638968586922,
0.020478764548897743,
0.011020868085324764,
0.0121803293004632,
0.04934989660978317,
-0.0037584539968520403,
-0.0007417137967422605,
-0.0026156590320169926,
0.01589685119688511,
-0.007014857605099678,
0.02187805250287056,
0.0141248544678092,
-0.017000779509544373,
-0.011531355790793896,
0.009285010397434235,
0.0720294788479805,
-0.027765139937400818,
0.008678440004587173,
-0.015350757166743279,
0.027290144935250282,
-0.03454166278243065,
0.028345132246613503,
0.01824348047375679,
0.02405165135860443,
-0.008789274841547012,
0.012373166158795357,
-0.012081813998520374,
0.023900087922811508,
0.025617757812142372,
-0.011223199777305126,
0.02345449849963188,
-0.030942505225539207,
-0.020266717299818993,
-0.028793932870030403,
-0.015469733625650406,
0.009141250513494015,
-0.02952355146408081,
0.007594483904540539,
-0.002228032797574997,
0.015225043520331383,
-0.023966822773218155,
0.02642058953642845,
-0.01330505684018135,
0.007718588225543499,
0.00881749577820301,
-0.021778646856546402,
-0.00048020470421761274,
-0.0066552371717989445,
0.01458067074418068,
0.013279618695378304,
-0.004385187290608883,
0.018020357936620712,
-0.01777968928217888,
0.018839985132217407,
0.009757621213793755,
-0.025476684793829918,
-0.011364786885678768,
0.022911546751856804,
0.0058881198056042194,
0.01883789710700512,
-0.012178324162960052,
0.015535995364189148,
-0.011954295448958874,
-0.01137513667345047,
-0.01514018140733242,
-0.01170123741030693,
0.004510157275944948,
0.006842165254056454,
0.029190925881266594,
-0.004751081112772226,
0.0018141823820769787,
0.030953653156757355,
-0.0003762231208384037,
0.007161899469792843,
-0.014661546796560287,
-0.021158013492822647,
0.012198167853057384,
0.013125350698828697,
-0.012037936598062515,
0.014424831606447697,
0.006498868577182293,
0.005923586897552013,
-0.004636810161173344,
0.002919911639764905,
0.0010652905330061913,
0.022966330870985985,
0.013816535472869873,
-0.015312956646084785,
-0.0028826138004660606,
0.007454981096088886,
-0.02662196010351181,
0.006411506794393063,
0.00438475189730525,
0.04070397466421127,
0.0028163527604192495,
-0.0027774532791227102,
0.003427213290706277,
-0.009486395865678787,
-0.011592943221330643,
0.04903331771492958,
0.02489382214844227,
0.008220050483942032,
-0.07447123527526855,
0.012805687263607979,
-0.018531160429120064,
-0.004827030934393406,
-0.012486368417739868,
-0.011805703863501549,
-0.016303904354572296,
-0.0036590632516890764,
0.004917536862194538,
0.0019417509902268648,
-0.010541178286075592,
0.0274549201130867,
0.00034054694697260857,
0.013048157095909119,
0.013980541378259659,
0.002721893135458231,
0.03470830246806145,
0.013914652168750763,
-0.020380664616823196,
0.010339346714317799,
0.014890947379171848,
-0.007661532610654831,
0.015117129310965538,
0.017280232161283493,
-0.002411197405308485,
-0.08070141077041626,
-0.009107595309615135,
-0.006848964374512434,
-0.030001051723957062,
-0.01070203073322773,
-0.014742822386324406,
0.022191138938069344,
-0.010952796787023544,
-0.01855718344449997,
-0.015995454043149948,
-0.034552451223134995,
0.011467700824141502,
-0.01700672321021557,
0.013490565121173859,
0.02063407003879547,
-0.005719725042581558,
0.016211003065109253,
0.027328606694936752,
0.006295160856097937,
-0.004411471076309681,
-0.0019316934049129486,
0.012332050129771233,
-0.007948578335344791,
-0.005779041443020105,
-0.013154208660125732,
0.010271702893078327,
0.0004426046507433057,
0.017669599503278732,
0.0126988235861063,
-0.0038554577622562647,
-0.005119668319821358,
-0.030994348227977753,
-0.014074355363845825,
-0.005615247413516045,
-0.006376598961651325,
-0.014344708062708378,
-0.021125953644514084,
0.0009975703433156013,
-0.017593294382095337,
-0.009543167427182198,
-0.001871034735813737,
0.023366408422589302,
0.006014298647642136,
0.0023113347124308348,
-0.013792735524475574,
-0.006384070962667465,
0.007184567395597696,
-0.004990087356418371,
0.008596387691795826,
-0.004620241932570934,
0.0018521175952628255,
-0.0043380060233175755,
-0.004738551564514637,
0.01121317595243454,
0.027916986495256424,
-0.017100892961025238,
-0.010170307010412216,
0.012355662882328033,
-0.0023553892970085144,
0.009682894684374332,
-0.016742950305342674,
0.00530199334025383,
0.004728972911834717,
0.07198359817266464,
-0.017219794914126396,
0.006290961056947708,
-0.035365134477615356,
-0.010366814211010933,
0.006549275480210781,
0.009081844240427017,
0.007670744322240353,
0.016159765422344208,
-0.02757992222905159,
0.013404715806245804,
-0.020800786092877388,
-0.01666470430791378,
0.010946802794933319,
0.013921409845352173,
-0.013720599934458733,
0.036944493651390076,
0.003038831055164337,
-0.005641896277666092,
-0.010436823591589928,
0.019778039306402206,
0.0009550671093165874,
0.004196366295218468,
-0.025762014091014862,
0.02254871279001236,
0.003902146592736244,
-0.0033862083218991756,
0.003893071785569191,
0.004029558971524239,
0.00025604129768908024,
-0.008460335433483124,
0.008141268976032734,
0.0008961089188233018,
-0.017999211326241493,
0.012753216549754143,
-0.007218764163553715,
0.007642582058906555,
-0.0011288045207038522,
-0.006570723373442888,
0.005542814265936613,
0.01085042767226696,
0.004464559722691774,
0.007097859866917133,
-0.0019721430726349354,
-0.02424909546971321,
0.0065288301557302475,
0.0009773013880476356,
-0.002765644807368517,
0.007430681958794594,
-0.0035144579596817493,
-0.024304229766130447,
0.006775389425456524,
0.001707147341221571,
0.007805586326867342,
0.003421067725867033,
0.006057059857994318,
-0.000048840418457984924,
0.0001143916742876172,
-0.021333470940589905,
-0.018983855843544006,
0.006527550984174013,
-0.008223406970500946,
0.02397756278514862,
-0.00915389135479927,
0.01023933943361044,
0.005393097177147865,
0.012780183926224709,
-0.012620797380805016,
-0.0008970159105956554,
0.014921477064490318,
0.010603776201605797,
-0.002036279533058405,
0.00637416634708643,
-0.004694140050560236,
0.01413796842098236,
-0.004025228321552277,
0.018924660980701447,
-0.013837875798344612,
0.010452233254909515,
0.004038339015096426,
-0.015541436150670052,
0.03165609389543533,
0.0074417609721422195,
0.015440956689417362,
-0.015870321542024612,
0.004060355946421623,
-0.008603185415267944,
-0.03880089521408081,
-0.005101523362100124,
0.011017424054443836,
0.005597401410341263,
-0.0144193135201931,
0.00886881910264492,
-0.013151019811630249,
0.009031759575009346,
0.03401174396276474,
0.020061183720827103,
0.012854850850999355,
0.017535511404275894,
0.015285750851035118,
0.005715829785913229,
-0.013678804971277714,
-0.00590162817388773,
-0.022912852466106415,
-0.0028457259759306908,
0.00016693351790308952,
-0.00032646465115249157,
-0.011534832417964935,
0.02114574983716011,
0.031039362773299217,
-0.01822579838335514,
0.02440182864665985,
0.047410085797309875,
0.0021558867301791906,
-0.011781308799982071,
0.012805460020899773,
-0.011494787409901619,
0.0224238783121109,
-0.017101548612117767,
-0.009254351258277893,
0.012195870280265808,
-0.011358551681041718,
0.01503828726708889,
-0.01627246104180813,
0.00903315469622612,
-0.0058969296514987946,
-0.01743629202246666,
0.00760460551828146,
-0.001964217983186245,
0.025122439488768578,
0.016842536628246307,
-0.014742124825716019,
0.008451081812381744,
0.0006041754968464375,
-0.010372166521847248,
-0.005796757526695728,
-0.03704099357128143,
0.02872106432914734,
0.0073000588454306126,
-0.00696377782151103,
0.005677299574017525,
-0.019825458526611328,
0.009229345247149467,
0.010878507047891617,
0.008894773200154305,
-0.014133507385849953,
-0.009129994548857212,
0.006638000253587961,
0.0077446275390684605,
0.000735139474272728,
0.006113792769610882,
0.006925104185938835,
0.00045409228187054396,
-0.00868208147585392,
0.005183949135243893,
0.01582324132323265,
-0.0016227085143327713,
-0.00810678955167532,
-0.02269124612212181,
0.0030876975506544113,
-0.023458613082766533,
0.007672423031181097,
-0.0210525281727314,
-0.009525353088974953,
0.016263198107481003,
-0.011208330281078815,
0.015162229537963867,
-0.0029546041041612625,
-0.02890600636601448,
0.015909893438220024,
0.0242959912866354,
-0.016425684094429016,
-0.05239880830049515,
0.015560941770672798,
-0.006933887489140034,
-0.017858847975730896,
-0.014982749707996845,
-0.006371014751493931,
0.02800612896680832,
0.0072125098668038845,
0.01585799641907215,
-0.02707282453775406,
-0.0035178055986762047,
-0.007196427322924137,
-0.016062423586845398,
-0.011989855207502842,
-0.017635313794016838,
-0.004291500896215439,
-0.013197160325944424,
-0.015656977891921997,
-0.012767408043146133,
-0.0141191016882658,
0.0041621383279562,
-0.011678662151098251,
-0.022973086684942245,
-0.019049206748604774,
-0.028519194573163986,
-0.006651818286627531,
0.0067091695964336395,
0.009480650536715984,
0.010020910762250423,
-0.01874573528766632
] | [
0.09960339963436127,
0.17937897145748138,
0.28162050247192383,
-0.2618977725505829,
0.1264885514974594,
-0.04056709632277489,
0.47229287028312683,
-0.45195868611335754,
0.06912916153669357,
-0.6516850590705872,
0.06735634803771973,
0.5782566070556641,
-0.5084297060966492,
-0.18507707118988037,
0.15838214755058289,
0.6077550649642944,
1.030788779258728,
0.4767252802848816,
-0.766415536403656,
-0.4152486324310303,
-0.25860029458999634,
-0.10493237525224686,
0.9588120579719543,
0.36554038524627686,
0.16063539683818817,
-0.3992934823036194,
0.22371512651443481,
0.1793191134929657,
0.20104002952575684,
0.0055034528486430645,
-0.11238717287778854,
0.5014001727104187,
0.0006990376859903336,
-0.40672895312309265,
-0.14610655605793,
0.23599685728549957,
-0.22053296864032745,
-0.5033988356590271,
0.27580028772354126,
-0.07262428104877472,
-0.02861124277114868,
0.09179001301527023,
0.3316875696182251,
0.75394207239151,
-0.05549834668636322,
0.16388332843780518,
-1.6309819221496582,
0.6470675468444824,
-0.020467806607484818,
0.48330309987068176,
0.29700344800949097,
0.031240975484251976,
0.3500085771083832,
0.36448433995246887,
0.5878704190254211,
0.23380233347415924,
-0.9231216907501221,
-0.04454199969768524,
0.4723316431045532,
-0.4668407738208771,
0.3469802141189575,
0.1115226000547409,
-0.5543906092643738,
0.1355605274438858,
-0.07420965284109116,
0.5772307515144348,
0.005480578634887934,
-0.05404186621308327,
-0.5999987721443176,
0.08320087194442749,
0.2651346027851105,
-0.39342787861824036,
-0.21087095141410828,
-0.1624152660369873,
-0.012394544668495655,
-0.2933759093284607,
-0.6427937150001526,
-0.34451615810394287,
-0.013795287348330021,
0.2886809706687927,
-0.01909894123673439,
0.44620242714881897,
0.36384525895118713,
0.054741621017456055,
0.21416182816028595,
-0.40851515531539917,
-0.018378177657723427,
1.221247673034668,
-0.38100266456604004,
-0.13007745146751404,
0.435918927192688,
-0.26237982511520386,
0.5909852385520935,
0.2378789186477661,
0.18265841901302338,
0.27014121413230896,
0.3678652346134186,
-0.20072735846042633,
-0.1270342767238617,
0.11504120379686356,
0.05499495565891266,
0.01532538142055273,
-0.294441819190979,
-0.39844372868537903,
0.051243335008621216,
-0.24848295748233795,
-0.32564711570739746,
-0.36186113953590393,
-0.22374482452869415,
0.20214813947677612,
-1.016780138015747,
-0.17649833858013153,
-0.4840641915798187,
-0.8431393504142761,
-0.19598650932312012,
-0.09626853466033936,
0.3929053544998169,
-0.0064703659154474735,
0.23408062756061554,
0.0021677676122635603,
0.07784923911094666,
0.8415728807449341,
-0.2123151272535324,
0.4092938303947449,
-0.5799815058708191,
-0.3254165053367615,
0.3559127748012543,
0.1326112300157547,
-0.10623756051063538,
0.4550808370113373,
0.09882161021232605,
0.9430382251739502,
-0.262776255607605,
-0.2798580825328827,
0.4437941014766693,
-0.24526835978031158,
-0.06704597920179367,
0.022443290799856186,
0.25604376196861267,
0.06407338380813599,
-0.1588446944952011,
-0.8380568027496338,
-0.4278976321220398,
0.1145746186375618,
-0.3425617814064026,
-0.23281225562095642,
-0.5198719501495361,
0.2218986302614212,
0.3852333426475525,
-0.40925827622413635,
0.3976956009864807,
-0.1823488473892212,
-0.47271984815597534,
0.2873276472091675,
-0.359190434217453,
0.07403671741485596,
0.27782487869262695,
-0.7782718539237976,
-0.1378782093524933,
0.020805617794394493,
0.05931422859430313,
-0.6612349152565002,
0.041839178651571274,
-0.3109651207923889,
0.29806408286094666,
0.10785894840955734,
0.07753898948431015,
0.5555334091186523,
0.29797661304473877,
-0.3004557490348816,
-0.6238325834274292,
-0.278739333152771,
0.45193105936050415,
-0.6097301244735718,
0.530001163482666,
-0.010785602033138275,
0.666054904460907,
-0.02815452218055725,
0.0292165856808424,
0.4579416811466217,
-0.8484752178192139,
-0.20791684091091156,
-0.12731531262397766,
-0.38434740900993347,
0.7871180772781372,
0.128090500831604,
0.4539583623409271,
-0.0168253555893898,
0.23440468311309814,
0.18409597873687744,
0.15197871625423431,
-0.6348637342453003,
0.834071159362793,
-0.48428982496261597,
1.581665277481079,
-0.2843119204044342,
-0.1273060292005539,
0.2171497792005539,
0.4890955686569214,
-0.4937000274658203,
0.021566445007920265,
0.15389384329319,
0.5147594213485718,
-0.38182106614112854,
-0.6629499197006226,
0.14443954825401306,
0.21275265514850616,
-0.28649353981018066,
-0.10699853301048279,
-0.010006344877183437,
0.6496950387954712,
-0.47712698578834534,
0.13925042748451233,
-0.1887657195329666,
0.3962666094303131,
-0.5504998564720154,
-0.44842877984046936,
-0.08248738199472427,
-0.5616820454597473,
-0.11062218993902206,
0.277007520198822,
-0.16458424925804138,
0.5155092477798462,
0.7574408054351807,
0.0013366633793339133,
0.39768239855766296,
0.5881838798522949,
0.0979938805103302,
0.9121336340904236,
-0.29254305362701416,
0.30491122603416443,
-0.2058226615190506,
-0.010861714370548725,
-0.49910467863082886,
-0.17430923879146576,
0.1841450035572052,
0.026654107496142387,
-0.10134954005479813,
0.2603806257247925,
-0.4251369535923004,
-0.17041167616844177,
0.5203179121017456,
-0.9032264351844788,
-0.11716797202825546,
0.31952670216560364,
-0.3828997015953064,
-0.26397186517715454,
-0.07002246379852295,
-0.7928129434585571,
0.09055240452289581,
0.23426266014575958,
0.3910070061683655,
0.2486935555934906,
-0.7280439734458923,
0.02451486885547638,
-0.30176493525505066,
0.15127155184745789,
0.1670578271150589,
-0.0861923024058342,
-0.6850631237030029,
-0.41869646310806274,
-0.37852025032043457,
0.17230083048343658,
0.10760556161403656,
-0.0709642693400383,
-0.2980470061302185,
-0.913621187210083,
-0.4422231912612915,
1.0302786827087402,
0.31872960925102234,
0.9232813119888306,
0.09342587739229202,
-0.746910035610199,
0.16991224884986877,
-0.3293304145336151,
-0.2170071303844452,
-0.0016142083331942558,
0.6794814467430115,
-0.4833572804927826,
-0.1685914546251297,
-0.06833397597074509,
0.8859235644340515,
0.9293409585952759,
-0.42018964886665344,
-0.5383778214454651,
0.5012725591659546,
-0.015534386970102787,
-0.44856858253479004,
-0.12936876714229584,
-0.40099775791168213,
-0.5971559882164001,
0.02131463773548603,
-0.11380255222320557,
0.13713178038597107,
0.5026025772094727,
-0.1334306299686432,
-0.029333651065826416,
0.5398097038269043,
0.3057394027709961,
-0.36042580008506775,
0.09036732465028763,
0.007565965875983238,
-0.5156930088996887,
-0.2299046367406845,
-0.18642935156822205,
0.07405449450016022,
-0.49284443259239197,
0.1822999119758606,
-5.7034912109375,
0.1689467430114746,
0.15663626790046692,
-0.14457327127456665,
0.30756476521492004,
0.15493632853031158,
0.46346768736839294,
-0.008072863332927227,
0.1932404637336731,
0.2325020581483841,
0.1623312532901764,
0.41752591729164124,
0.5709981322288513,
0.11788260191679001,
-0.585375189781189,
-0.17367298901081085,
-0.3630527853965759,
-0.3006809949874878,
0.1594046652317047,
-0.18035686016082764,
0.42560461163520813,
-0.3028889000415802,
-0.09893614053726196,
0.7991049289703369,
0.06407494843006134,
-0.5694494247436523,
-0.5563223958015442,
0.48299935460090637,
0.018354682251811028,
-0.45884013175964355,
-0.21825480461120605,
-0.4590211510658264,
0.30286771059036255,
-0.06879305094480515,
0.5782012343406677,
0.13671478629112244,
-0.2092994898557663,
-0.18845894932746887,
-0.4697043299674988,
-0.38815852999687195,
0.05810418725013733,
-0.31138262152671814,
-0.3354681432247162,
-0.10925576090812683,
0.27026644349098206,
0.012856834568083286,
0.03671944513916969,
0.023999711498618126,
-0.1829405277967453,
0.8589245676994324,
0.33227866888046265,
-0.11531777679920197,
0.4227950870990753,
0.2908289432525635,
0.9834523797035217,
0.1777830570936203,
0.2650364637374878,
0.1553332656621933,
0.15882688760757446,
-0.002665250562131405,
-0.7255092859268188,
0.1372743844985962,
-0.5744547843933105,
-0.057150810956954956,
-0.1487717628479004,
0.5298254489898682,
-0.31082606315612793,
-0.33364516496658325,
0.6765537261962891,
-0.45377033948898315,
-0.39894527196884155,
0.5604354739189148,
0.3076692521572113,
-0.8755362629890442,
0.7555995583534241,
-0.05703732371330261,
0.4815075099468231,
0.2708895802497864,
-0.05904432386159897,
-0.2502683699131012,
-0.4365251660346985,
-0.10104925185441971,
-0.44864964485168457,
-0.42648327350616455,
-0.028732718899846077,
-0.4389271140098572,
-0.40201473236083984,
-0.21896834671497345,
0.1500415802001953,
0.39146777987480164,
0.4420124292373657,
-0.33314862847328186,
0.006891752127557993,
0.2947748303413391,
0.141263946890831,
0.49975764751434326,
0.35916244983673096,
0.5261813998222351,
0.8183230757713318,
0.3554617464542389,
1.0331165790557861,
-0.07621879130601883,
-0.38159775733947754,
-0.5671183466911316,
-0.23655349016189575,
-0.04639414697885513,
-0.4944250285625458,
-0.1421349048614502,
0.8301824927330017,
-0.922519862651825,
0.30670809745788574,
-0.21367545425891876,
-0.7088460326194763,
-0.480807363986969,
0.5996046662330627,
-0.4279986023902893,
-0.45346492528915405,
0.2830740511417389,
0.9702149033546448,
-0.39334288239479065,
0.46357518434524536,
0.4603145718574524,
-0.4143292307853699,
-0.07842700183391571,
-0.13655634224414825,
0.6303026080131531,
0.19308620691299438,
0.6540868878364563,
-0.9917090535163879,
-0.20807327330112457,
0.37162867188453674,
0.49770522117614746,
-0.17030568420886993,
0.42265477776527405,
0.1935509890317917,
-0.3614247441291809,
-0.15444470942020416,
0.5400118827819824,
0.7883669137954712,
-0.3893468976020813,
0.4942161440849304,
-0.6106938123703003,
-0.1788146197795868,
-0.5541126132011414,
0.27419576048851013,
0.4340827465057373,
-0.26466473937034607,
-0.17991474270820618,
-0.339685320854187,
-0.05393125116825104,
0.20791088044643402,
0.1904831826686859,
-0.0695815458893776,
0.05597512051463127,
-0.5159284472465515,
0.27133771777153015,
0.14555728435516357,
-0.13201099634170532,
0.15760739147663116,
-0.6257447004318237,
0.2256024330854416,
0.44992196559906006,
-0.9931538701057434,
-0.3160709738731384,
-0.3800136148929596,
-0.21879100799560547,
-0.22893820703029633,
-0.6350529789924622,
-0.060699015855789185,
0.3476051092147827,
-0.6219425797462463,
-0.2648102939128876,
-0.19524389505386353,
-0.17839044332504272,
0.373694509267807,
-0.5795815587043762,
-0.5254436731338501,
0.047788020223379135,
0.1850164830684662,
-0.09943565726280212,
0.28435018658638,
-0.31244611740112305,
0.13565392792224884,
0.1926800012588501,
0.3810468316078186,
-0.3380487263202667,
0.2955746054649353,
-0.2880267798900604,
-0.42229390144348145,
-0.47567272186279297,
0.5839376449584961,
0.2689460515975952,
-0.011146371252834797,
-0.1381518393754959,
0.3704187870025635,
0.22246268391609192,
0.16235314309597015,
0.1487516611814499,
-0.2528335154056549,
-0.4382810890674591,
0.11048334091901779,
0.25342026352882385,
-0.369486004114151,
0.360194593667984,
0.36742010712623596,
0.11904667317867279,
-0.21630972623825073,
0.3594505786895752,
-0.3076933026313782,
-0.08731357008218765,
-0.15457387268543243,
-0.6093738675117493,
-0.10693223774433136,
0.3736054599285126,
-0.2966654598712921,
-0.07845349609851837,
0.3998202979564667,
-0.34297457337379456,
-0.48296594619750977,
0.024816935881972313,
0.23191392421722412,
0.0509052574634552,
0.2225126475095749,
0.06434635818004608,
-0.6426185965538025,
0.14252932369709015,
0.19912530481815338,
-0.7595967650413513,
0.10335303097963333,
-0.1426399052143097,
-0.26713818311691284,
-0.029788052663207054,
0.009194045327603817,
-0.14408840239048004,
0.049245964735746384,
-0.5551848411560059,
-0.3928329050540924,
0.10730636119842529,
-0.6376379132270813,
0.2843204438686371,
0.23474818468093872,
0.5414929986000061,
-0.334958016872406,
0.04713063687086105,
-0.1356198787689209,
0.23922374844551086,
0.3070332109928131,
-0.8907521367073059,
-0.425536572933197,
-0.009134840220212936,
0.36402150988578796,
-0.07911460101604462,
0.029121501371264458,
0.25179052352905273,
0.8000509738922119,
-0.34997713565826416,
0.05300140380859375,
-0.4976791739463806,
-0.09626739472150803,
0.30785754323005676,
-0.35455796122550964,
-0.20561683177947998,
-0.21948039531707764,
0.2796773910522461,
0.650618314743042,
0.05725504085421562,
-0.1656499207019806,
-0.8240793347358704,
0.4008939862251282,
-0.2716919481754303,
0.29783156514167786,
0.09508159756660461,
0.6262039542198181,
0.08464796841144562,
-0.22957278788089752,
0.37915414571762085,
-0.4728580713272095,
-0.3731510043144226,
-0.048244573175907135,
0.2712480127811432,
-0.13258998095989227,
-0.5553194880485535,
0.10116726160049438,
-0.5375847220420837,
0.529296338558197,
-0.6303321123123169,
0.14636334776878357,
-0.5141032338142395,
-0.37651312351226807,
-0.28818100690841675,
0.09857729822397232,
-0.1459164023399353,
-0.5114652514457703,
-0.488654762506485,
0.3853833079338074,
0.3509412705898285,
-0.18712355196475983,
0.2437211126089096,
-0.03693102300167084,
-0.10808221250772476,
-0.5820383429527283,
0.38625016808509827,
0.21198630332946777,
-0.2637947201728821,
0.030200570821762085,
0.16044247150421143,
-0.011505844071507454,
-0.02373487688601017,
-0.7086543440818787,
-0.15781132876873016,
0.2532189190387726,
-0.005327066872268915,
0.05075232684612274,
0.3498295843601227,
-0.23193871974945068,
0.2703911364078522,
-0.31213730573654175,
0.06526969373226166,
0.2842552959918976,
0.28773975372314453,
0.4018043875694275,
0.30157867074012756,
0.6218233108520508,
0.18506568670272827,
-0.5412328243255615,
0.29141995310783386,
0.12671902775764465,
0.23467332124710083,
0.15167441964149475,
0.8568727374076843,
1.0068641901016235,
0.3052788972854614,
-0.06658795475959778,
0.9014289975166321,
0.36723482608795166,
-0.21315120160579681,
-0.21370290219783783,
-0.3783974349498749,
-0.3888216018676758,
0.2774769067764282,
0.44784411787986755,
0.3657706379890442,
0.11728228628635406,
0.24544964730739594,
0.28930360078811646,
0.5445285439491272,
-0.03140728175640106,
-0.18274448812007904,
-0.09304879605770111,
-0.10300753265619278,
0.24088700115680695,
-0.4689033031463623,
0.008438927121460438,
-0.3284631669521332,
-0.7735981941223145,
0.5433264374732971,
0.462700754404068,
-0.4158496856689453,
-0.15441074967384338,
0.24891376495361328,
-0.30143094062805176,
-0.11924399435520172,
-0.020578332245349884,
0.706624448299408,
0.05987834557890892,
-0.07923022657632828,
0.09150363504886627,
-0.331310898065567,
0.3861740529537201,
-0.10716812312602997,
-0.1622471660375595,
0.22593235969543457,
-0.4229141175746918,
0.08982822299003601,
0.12101410329341888,
-0.16011321544647217,
0.23095495998859406,
-0.13336428999900818,
0.23799969255924225,
0.5535465478897095,
-0.35453975200653076,
0.473066508769989,
-0.6475455164909363,
-0.7612332701683044,
-0.08627206832170486,
-0.016851842403411865,
0.21658438444137573,
-0.06053585186600685,
0.21216514706611633,
-0.031176066026091576,
0.08956053853034973,
-0.640593945980072,
-0.0021223549265414476,
0.4425335228443146,
0.15386569499969482,
-0.5549085140228271,
0.25396132469177246,
-0.25203737616539,
0.3798283636569977,
0.38191846013069153,
0.03719750791788101,
0.4091283977031708,
-0.19093096256256104,
0.18566696345806122,
-1.23281991481781,
0.5487083792686462,
-0.11518117785453796,
-0.1322777271270752,
-0.3450019955635071,
0.014234097674489021,
1.0991733074188232,
1.085085391998291,
-0.02934691123664379,
0.09977132081985474,
0.4008899927139282,
0.1343875527381897,
0.15498396754264832,
-0.561413049697876,
-0.20441292226314545,
-0.36380094289779663,
0.05595173314213753,
-0.8598247170448303,
0.5075511336326599,
-0.1445312798023224,
-0.12944923341274261,
-0.05109341815114021,
0.3548581898212433,
0.08441609889268875,
-0.06451358646154404,
0.34682145714759827,
-0.48057687282562256,
0.39854657649993896,
-0.9211747050285339,
-0.00923839770257473,
-0.3428327739238739,
0.24413135647773743,
-0.350385844707489,
-0.08595027029514313,
-0.17775899171829224,
-0.27344396710395813,
0.3607347905635834,
-0.22028715908527374,
-0.3202512860298157,
0.033297475427389145,
0.06406905502080917,
-0.01535146962851286,
0.060914866626262665,
-0.5100196003913879,
-0.2281166911125183,
0.5180569887161255,
0.6401877403259277,
-0.7188838720321655,
0.10670443624258041,
0.04275510087609291,
0.1961814910173416,
-0.16460451483726501,
-0.03484709933400154,
0.03948895260691643,
-0.036014124751091,
0.022991761565208435
] |
SUMMARY Recent literature has demonstrated the usefulness of fitness and computer-based cognitive training as a means to enhance cognition and brain function. However, it is unclear whether the combination of fitness and cognitive training that results from years of extensive sport training also results in superior performance on tests of cognitive processes. In this study we examine, in a quantitative meta-analysis (k ¼20), the relationship between expertise in sports and laboratory-based measures of cognition. We found that athletes performed better on measures of processing speed and a category of varied attentionalparadigms, andathletesfrominterceptive sporttypesandmalesshowedthelargesteffects. Based on our results, more research should be done with higher-level cognitive tasks, such as tasks of executive function and more varied sub-domains of visual attention. Furthermore, future studies should incorporate more female athletes and use a diverse range of sport types and levelsof expertise. | [
0.00004877382889389992,
0.005044504068791866,
-0.006100979167968035,
0.001178729347884655,
0.0031509019900113344,
-0.007975994609296322,
0.009697312489151955,
-0.014228761196136475,
-0.006235127337276936,
0.010657340288162231,
0.00048528227489441633,
0.01722397468984127,
-0.00041638873517513275,
0.01365822646766901,
-0.009613619185984135,
0.0117890490218997,
-0.0058832429349422455,
0.020982500165700912,
0.002470337087288499,
0.03275124728679657,
-0.0136664854362607,
0.007954683154821396,
0.009969204664230347,
-0.013976691290736198,
-0.0058944812044501305,
0.027465391904115677,
-0.01156570389866829,
0.009558986872434616,
0.02057170495390892,
-0.03905085101723671,
-0.008067140355706215,
-0.0005740540800616145,
0.01246880367398262,
0.01942291297018528,
0.01377461850643158,
-0.00377696193754673,
-0.0012992250267416239,
0.01808161288499832,
-0.029905129224061966,
-0.002999990712851286,
0.009295257739722729,
-0.0028905305080115795,
0.005640309303998947,
-0.003877602517604828,
-0.01072738878428936,
-0.003550957655534148,
-0.0038312640972435474,
-0.016356660053133965,
-0.008185217157006264,
0.018023736774921417,
-0.008161300793290138,
-0.01978573389351368,
0.0005043132114224136,
-0.012705664150416851,
-0.006570269353687763,
-0.006758242845535278,
0.018543437123298645,
0.008617227897047997,
-0.0067096492275595665,
0.015271591022610664,
-0.003304998157545924,
-0.0006771649932488799,
0.0013233101926743984,
-0.01064852811396122,
-0.0077393813990056515,
-0.06704066693782806,
-0.017601704224944115,
0.007065107114613056,
0.018147004768252373,
-0.007314352784305811,
0.0013820198364555836,
0.015410897321999073,
-0.012143130414187908,
0.037066198885440826,
0.02236180752515793,
0.0007990328595042229,
-0.005417786538600922,
0.0011469046585261822,
0.0235905721783638,
-0.01305648684501648,
-0.02249995619058609,
0.004177386872470379,
0.019384000450372696,
0.03203209489583969,
0.006600487045943737,
-0.00019354361575096846,
0.00003383785951882601,
-0.019333234056830406,
0.00860641524195671,
0.01274239830672741,
0.00747326435521245,
0.006810350343585014,
0.002982138656079769,
0.011769590899348259,
-0.0340847373008728,
0.0076634325087070465,
0.004327165894210339,
0.010329599492251873,
0.02155885100364685,
-0.024648528546094894,
-0.008218850940465927,
0.0037918572779744864,
0.027335550636053085,
-0.004719782620668411,
0.003066801931709051,
0.0071746576577425,
0.006391544826328754,
0.007636046037077904,
0.00823271181434393,
0.003927348181605339,
0.012464884668588638,
0.007176321931183338,
-0.025073256343603134,
0.01195981353521347,
0.021967904642224312,
-0.007240745238959789,
0.019626688212156296,
-0.010894832201302052,
0.009732228703796864,
-0.002432621782645583,
0.028063423931598663,
0.049804866313934326,
0.0012765119317919016,
-0.025608131662011147,
-0.002853670623153448,
-0.005059710703790188,
0.027238572016358376,
0.00369249377399683,
-0.0004711890360340476,
-0.002530793659389019,
-0.010443557053804398,
0.0001612494233995676,
0.010853230953216553,
-0.001241218065842986,
-0.00596586661413312,
-0.02207452431321144,
0.005326686892658472,
-0.005612092092633247,
-0.0011720991460606456,
-0.020374368876218796,
-0.00291302427649498,
0.005153181962668896,
-0.006160566583275795,
0.02071862295269966,
0.014062481001019478,
-0.0158547256141901,
-0.009249293245375156,
0.01157723180949688,
0.012153818272054195,
-0.029971525073051453,
0.009422190487384796,
-0.01609107293188572,
-0.011117661371827126,
-0.02815690077841282,
-0.005878383293747902,
-0.004395666066557169,
-0.0080879433080554,
0.01740911230444908,
-0.004691987298429012,
-0.03443343937397003,
0.008388965390622616,
0.010526236146688461,
0.024259023368358612,
0.007972593419253826,
0.004845122806727886,
0.017720989882946014,
-0.013791436329483986,
-0.01009624544531107,
-0.004287899471819401,
0.001229952904395759,
-0.01229090429842472,
0.01540039200335741,
-0.004012753255665302,
0.01053338497877121,
-0.005347062833607197,
-0.007622798439115286,
0.04213503375649452,
0.009693003259599209,
-0.0020096010994166136,
0.06743431091308594,
0.019593099132180214,
0.030073082074522972,
-0.013704553246498108,
0.027659766376018524,
-0.001259156852029264,
-0.021500851958990097,
0.025677526369690895,
-0.01110258512198925,
0.005461986642330885,
-0.027899034321308136,
-0.015373233705759048,
-0.01361118908971548,
0.007091898005455732,
0.02500205673277378,
0.0006759669631719589,
0.0036231232807040215,
0.024804290384054184,
0.007580051198601723,
-0.008201572112739086,
-0.02017669752240181,
-0.0012333118356764317,
0.016306644305586815,
0.013620231300592422,
0.028180086985230446,
-0.03989876061677933,
0.002941381186246872,
0.025388773530721664,
-0.00836239568889141,
-0.00669014360755682,
-0.01527569629251957,
0.01675858348608017,
-0.021271152421832085,
-0.0012787656160071492,
-0.015018140897154808,
0.005980878137052059,
0.010502963326871395,
0.008009746670722961,
0.007756828796118498,
-0.015207522548735142,
-0.00848544854670763,
0.008898921310901642,
-0.004613711033016443,
0.002954055555164814,
-0.02795388549566269,
0.00013143941760063171,
0.013207155279815197,
-0.021099664270877838,
0.009466907009482384,
-0.004956395365297794,
-0.004397987388074398,
0.006393916439265013,
0.01752486824989319,
-0.010969750583171844,
-0.04718784987926483,
-0.004762543365359306,
0.0043557132594287395,
0.011592661030590534,
-0.009678179398179054,
0.009471394121646881,
-0.0023345237132161856,
-0.020155157893896103,
-0.02989824488759041,
0.03722120821475983,
-0.037282951176166534,
0.01137477345764637,
0.008856769651174545,
0.009084904566407204,
-0.016122855246067047,
0.017279691994190216,
-0.006891078315675259,
0.004052322823554277,
-0.021283667534589767,
-0.005354955792427063,
-0.004322575870901346,
-0.012433573603630066,
0.0008421721868216991,
0.009306774474680424,
-0.005040186922997236,
0.022420339286327362,
-0.012532517313957214,
0.005764990113675594,
0.008152751252055168,
-0.013438371010124683,
0.024153433740139008,
0.007115596439689398,
0.023670073598623276,
0.00952034629881382,
-0.006994061637669802,
0.0015131104737520218,
0.007030871231108904,
0.0031567425467073917,
-0.01061917096376419,
-0.014359311200678349,
-0.08155132830142975,
-0.003945596516132355,
-0.021502234041690826,
0.00007675203960388899,
0.011826789006590843,
0.021617569029331207,
-0.024785520508885384,
0.014811177738010883,
-0.012856762856245041,
0.009079720824956894,
0.011749718338251114,
-0.00712026609107852,
-0.015011335723102093,
0.029080890119075775,
-0.012257333844900131,
-0.014337616972625256,
0.009522386826574802,
-0.002274915110319853,
-0.011347653344273567,
-0.010891852900385857,
-0.01100968662649393,
-0.020558105781674385,
-0.007512354291975498,
0.0035518407821655273,
-0.015956535935401917,
-0.03793852776288986,
0.006903978064656258,
-0.013953125104308128,
0.04942375421524048,
0.017478007823228836,
0.0038788774982094765,
0.007600174285471439,
-0.013697982765734196,
0.015813730657100677,
-0.009508167393505573,
-0.006358325015753508,
-0.012717112898826599,
0.02172495797276497,
-0.004780156537890434,
0.022368576377630234,
0.019622087478637695,
0.010786890983581543,
-0.012629036791622639,
-0.0040737600065767765,
0.005642022471874952,
0.0037268551532179117,
0.015881024301052094,
0.025721963495016098,
0.01593368873000145,
-0.006746903993189335,
0.00453659612685442,
-0.014545021578669548,
0.008270034566521645,
0.005980223882943392,
-0.008588721044361591,
-0.016482537612318993,
0.01574762538075447,
0.057276591658592224,
-0.012937999330461025,
-0.0064256018958985806,
-0.03257641941308975,
-0.014953725971281528,
0.002912915777415037,
0.023696184158325195,
0.048106350004673004,
-0.007977379485964775,
0.008664580062031746,
0.0119794812053442,
0.009855094365775585,
0.02813451737165451,
-0.010589650832116604,
-0.01118163950741291,
-0.026217684149742126,
0.002980828285217285,
0.0036560785956680775,
-0.022472605109214783,
-0.016521543264389038,
0.0017659392906352878,
0.040344566106796265,
-0.012608545832335949,
0.008209509775042534,
0.008900555782020092,
0.009929900988936424,
-0.014250856824219227,
-0.024536343291401863,
-0.007011465262621641,
-0.0024030511267483234,
-0.01304592378437519,
0.01465316116809845,
-0.011731168255209923,
0.004064525943249464,
0.009547635912895203,
0.011741825379431248,
-0.0005235629505477846,
-0.0014935489743947983,
-0.016195379197597504,
-0.01135635282844305,
0.00032632402144372463,
-0.007203185465186834,
0.0107275964692235,
0.006595639977604151,
0.009085568599402905,
-0.015834396705031395,
-0.01115538738667965,
0.02129494771361351,
0.014204151928424835,
0.007874807342886925,
-0.016079409047961235,
-0.009913500398397446,
-0.014409517869353294,
-0.036743007600307465,
-0.02440468594431877,
-0.009364845231175423,
0.018062511458992958,
0.010774371214210987,
0.013901873491704464,
-0.02514713630080223,
0.007755809463560581,
0.0726161003112793,
-0.0005551871145144105,
0.00195797230117023,
-0.006088987458497286,
0.016081728041172028,
-0.03311656042933464,
0.008391027338802814,
-0.006361929699778557,
0.034273214638233185,
-0.011003579013049603,
0.011123213917016983,
0.013450909405946732,
-0.01684071682393551,
0.036968279629945755,
-0.00960649736225605,
-0.003565700026229024,
0.036626510322093964,
-0.017908398061990738,
-0.027705570682883263,
-0.02993685007095337,
0.0076022399589419365,
-0.005530515685677528,
-0.004249718971550465,
-0.015944985672831535,
0.011582263745367527,
-0.058642011135816574,
0.013613810762763023,
-0.011067491956055164,
-0.0036820105742663145,
0.001741433865390718,
-0.011839058250188828,
0.002492561936378479,
-0.0028904112987220287,
0.02179883047938347,
-0.007512748707085848,
0.013828528113663197,
0.041919175535440445,
-0.01122058555483818,
-0.001490968745201826,
0.027885019779205322,
-0.00458737974986434,
-0.017974741756916046,
0.00007786694914102554,
0.02178673818707466,
0.009493791498243809,
-0.02257760800421238,
-0.012519296258687973,
-0.0005027981242164969,
-0.018835099413990974,
0.011282787658274174,
-0.017553633078932762,
0.013252069242298603,
0.004815961699932814,
0.01873098872601986,
-0.02102995477616787,
0.00404848949983716,
-0.01775762066245079,
0.00349206174723804,
-0.03203956037759781,
-0.004780287388712168,
-0.002778727561235428,
-0.020315520465373993,
-0.01808539405465126,
-0.03745493292808533,
-0.023049678653478622,
-0.020216846838593483,
0.00924068782478571,
-0.000716840848326683,
-0.002774823922663927,
-0.00729211512953043,
-0.0188211128115654,
-0.02636878378689289,
0.01742122694849968,
-0.0017704488709568977,
0.009700319729745388,
-0.026277834549546242,
-0.009973486885428429,
0.010303166694939137,
-0.027138875797390938,
-0.01449788548052311,
-0.015976522117853165,
-0.024507345631718636,
0.018931174650788307,
-0.010832564905285835,
0.010362938046455383,
0.02901408076286316,
0.0005841599777340889,
-0.07422290742397308,
-0.007648319937288761,
0.005731743294745684,
-0.01219951268285513,
-0.0016537150368094444,
0.043901391327381134,
-0.02113758772611618,
-0.004744057077914476,
-0.006331352051347494,
0.0037381555885076523,
-0.02529843896627426,
0.010629678145051003,
-0.006958889774978161,
-0.020546969026327133,
0.012243527919054031,
-0.005725070834159851,
-0.020113419741392136,
0.019062913954257965,
0.026512620970606804,
0.009561637416481972,
-0.014724703505635262,
0.020368343219161034,
-0.01589740812778473,
0.008994407951831818,
-0.00849926471710205,
-0.0813484936952591,
0.006613406352698803,
0.005738725885748863,
-0.02094309963285923,
-0.029116004705429077,
-0.02098117023706436,
0.029148273169994354,
-0.006154565140604973,
0.006556167267262936,
-0.0169047974050045,
-0.033076245337724686,
0.00885759200900793,
-0.008714275434613228,
0.007981284521520138,
0.024347679689526558,
0.0003953204140998423,
0.009095368906855583,
-0.014744259417057037,
0.000956828473135829,
-0.04199853539466858,
-0.004667332395911217,
-0.00815886352211237,
-0.009680213406682014,
0.008527543395757675,
-0.009744454175233841,
-0.015859350562095642,
-0.00007903343066573143,
0.010474009439349174,
0.03208330273628235,
-0.0032670730724930763,
0.0208737775683403,
-0.0006639591883867979,
-0.01630554161965847,
0.0055780112743377686,
-0.011496154591441154,
-0.009197261184453964,
-0.030832208693027496,
-0.01197889819741249,
0.011416209861636162,
-0.007972251623868942,
-0.006262772250920534,
-0.005644748453050852,
0.01517726480960846,
0.0034743028227239847,
0.017193883657455444,
-0.017096973955631256,
0.003670420963317156,
-0.0038107221480458975,
0.018694765865802765,
-0.01914692297577858,
0.012664485722780228,
-0.0008907420560717583,
0.026264645159244537,
0.0026111090555787086,
0.015219993889331818,
0.010521812364459038,
-0.00999775342643261,
0.009538345970213413,
-0.002325682435184717,
0.005525656975805759,
-0.00788088608533144,
0.042684756219387054,
-0.006994203198701143,
0.07243280112743378,
-0.016987575218081474,
0.0017085950821638107,
-0.024505693465471268,
-0.000976216048002243,
-0.005782163701951504,
0.0006557917222380638,
-0.03042326122522354,
0.00028335803654044867,
-0.016646813601255417,
0.006896390113979578,
-0.007645559497177601,
-0.0073920912109315395,
0.0024117466527968645,
0.006696129683405161,
-0.003382243914529681,
0.0072485958226025105,
0.00890270434319973,
0.0034701372496783733,
0.019800927489995956,
0.02259867824614048,
0.01434636116027832,
0.005037565715610981,
0.02693832665681839,
0.010659553110599518,
-0.007651480846107006,
0.007485425099730492,
0.007249059621244669,
0.012904183007776737,
-0.012160444632172585,
-0.02010447159409523,
0.0054720742627978325,
0.0026072205509990454,
0.0038125761784613132,
0.015215430408716202,
-0.02370464988052845,
0.002235789317637682,
0.0014201675076037645,
-0.03442870080471039,
-0.0032287053763866425,
-0.021221302449703217,
0.011172457598149776,
0.004235614091157913,
0.02141355723142624,
0.003769943490624428,
0.019660232588648796,
0.016919545829296112,
-0.006862333510071039,
0.03767657279968262,
0.01699698343873024,
-0.01949779875576496,
-0.006009810138493776,
0.014272956177592278,
0.0222884900867939,
-0.0022605471312999725,
0.006639851722866297,
0.0015314801130443811,
0.0197138674557209,
0.018146853893995285,
-0.010158210061490536,
-0.007153380662202835,
-0.022171292454004288,
0.005608118139207363,
-0.0036281696520745754,
0.00582573376595974,
0.011739104986190796,
0.01904875412583351,
-0.007042640820145607,
-0.04699794948101044,
0.012609865516424179,
0.008571341633796692,
0.026464156806468964,
0.004899649880826473,
-0.01151866652071476,
0.008233750239014626,
-0.006956978235393763,
-0.002727002836763859,
0.013273540884256363,
0.030714819207787514,
0.01359800435602665,
-0.012937245890498161,
0.0075026610866189,
-0.018296925351023674,
0.0018193195573985577,
0.026362575590610504,
0.018762748688459396,
-0.00840255431830883,
0.029089409857988358,
-0.004336546175181866,
0.007947898469865322,
0.004834551829844713,
0.0010761574376374483,
0.000640948535874486,
0.008970582857728004,
0.0078048561699688435,
0.03381555527448654,
0.006507204379886389,
-0.0009523096960037947,
0.0160423144698143,
0.004197981674224138,
-0.00044706743210554123,
0.03693002089858055,
0.0007865740917623043,
0.01412107888609171,
-0.0007927082479000092,
-0.01610775850713253,
0.013740072958171368,
-0.02293909713625908,
0.019872386008501053,
0.012405592948198318,
0.005209820810705423,
-0.033369116485118866,
0.02859809435904026,
0.01870276778936386,
0.0041637602262198925,
0.006530075799673796,
-0.014482678845524788,
-0.019778352230787277,
-0.002015695907175541,
-0.007091511972248554,
-0.0005949949845671654,
-0.010810472071170807,
-0.017580123618245125,
-0.01408255472779274,
0.017900066450238228,
-0.03478449583053589,
-0.013832733035087585,
0.012657521292567253,
0.022346608340740204,
0.009669945575296879,
-0.008613146841526031,
0.0064989845268428326,
0.014836013317108154,
0.01753995195031166,
0.016828786581754684,
0.012295889668166637,
0.00292383786290884,
0.02966700680553913,
-0.012570278719067574,
0.002614719793200493,
0.03039572574198246,
-0.012344199232757092,
-0.008040912449359894,
0.00033137318678200245,
0.006662210449576378,
-0.01167294755578041,
0.011507879011332989,
-0.00561923161149025,
0.009358908981084824,
0.021950814872980118,
0.010359758511185646,
0.02311898022890091,
-0.02881578542292118,
-0.0010965501423925161,
-0.011191187426447868,
0.022312819957733154,
0.0059908656403422356,
0.011809716001152992,
-0.015663092955946922,
-0.021963883191347122,
0.008676457218825817,
-0.03608833625912666,
-0.018150661140680313,
0.01331912912428379,
0.02277480810880661,
0.025012513622641563,
-0.01777498796582222,
0.010098127648234367,
-0.00411167461425066,
-0.01523645780980587,
0.0300991702824831,
-0.025193234905600548,
0.004238317720592022,
0.011802980676293373,
-0.021471112966537476,
-0.01651204377412796,
0.0038654361851513386,
0.023786135017871857,
-0.009105110540986061,
0.03509613871574402,
0.00745990127325058,
-0.012684520334005356,
-0.003009074367582798,
-0.00965188816189766,
-0.0021564678754657507,
0.01969219744205475,
0.0005209851660765707,
-0.0029000891372561455,
-0.005138554610311985,
0.01971983164548874,
0.012042698450386524,
-0.02056410349905491,
-0.019360292702913284,
0.004367525689303875,
-0.014701133593916893,
-0.016596976667642593,
0.008429402485489845,
0.011108247563242912,
-0.014868559315800667,
0.011738765984773636,
0.006274539045989513,
-0.014229963533580303
] | [
0.33921292424201965,
0.09137111157178879,
-0.27994829416275024,
0.3235701322555542,
-0.18160325288772583,
0.24182581901550293,
0.5122941136360168,
-0.12577153742313385,
-0.49300435185432434,
-0.5313697457313538,
0.06965506821870804,
0.4738050699234009,
0.3702801764011383,
-0.15738756954669952,
-0.22979983687400818,
0.40603893995285034,
0.3453212380409241,
0.3951157331466675,
0.06872258335351944,
-0.3579529821872711,
-0.3536822199821472,
-0.11253277957439423,
0.09801863878965378,
-0.08418518304824829,
0.01653294637799263,
0.21138940751552582,
0.1476403921842575,
0.45930325984954834,
-0.4980275332927704,
-0.30911728739738464,
-0.38996660709381104,
0.5348998308181763,
-0.2671724259853363,
0.00653619971126318,
-0.19395381212234497,
-0.04503333568572998,
0.25684064626693726,
-0.05385187268257141,
-0.0974363312125206,
-0.6166989207267761,
0.027490893378853798,
0.17702685296535492,
-0.4449169635772705,
0.4962567985057831,
-0.41887393593788147,
-0.3031362295150757,
-1.4491169452667236,
-0.10016924142837524,
-0.6546696424484253,
0.261148601770401,
-0.15012425184249878,
0.5211928486824036,
0.13634583353996277,
0.3923373222351074,
-0.15530754625797272,
0.5613654255867004,
-0.021027296781539917,
-0.004617882426828146,
0.04173670709133148,
-0.5489113330841064,
0.05838146060705185,
-0.09390534460544586,
0.044311780482530594,
0.16245102882385254,
-0.2650544047355652,
-0.013381247408688068,
0.22986455261707306,
-0.1434967964887619,
-0.29867732524871826,
-0.16225318610668182,
0.3139588236808777,
-0.3515762388706207,
-0.1208941638469696,
0.23856210708618164,
-0.2252712994813919,
-0.2111404687166214,
0.01226732600480318,
0.0010392260737717152,
0.3775147795677185,
-0.571426510810852,
0.34024351835250854,
-0.19729886949062347,
0.6641682982444763,
0.08017867058515549,
0.34360581636428833,
0.4496704638004303,
-0.009932405315339565,
0.40287673473358154,
-0.4216116964817047,
0.4549427032470703,
0.027502043172717094,
-0.3080684244632721,
0.4821156859397888,
0.3412022590637207,
0.49935588240623474,
0.3918374180793762,
0.02815260924398899,
-0.11807873845100403,
0.10359840095043182,
-0.1667657047510147,
-0.0754408910870552,
-0.2710941731929779,
0.11337751895189285,
0.16884157061576843,
-0.174814835190773,
-0.49284642934799194,
-0.09008888155221939,
-0.6685290336608887,
-0.19904404878616333,
0.10668987780809402,
-0.8004887700080872,
0.2845642864704132,
0.01554842758923769,
0.14791308343410492,
0.04821474477648735,
0.04980708658695221,
0.07441389560699463,
0.1406518816947937,
-0.37402793765068054,
0.4485975503921509,
-0.029570961371064186,
0.872410237789154,
0.32677552103996277,
0.10331348329782486,
0.19158492982387543,
0.2276986539363861,
0.3751790225505829,
0.4933364987373352,
-0.06678411364555359,
0.006112408824265003,
0.21893149614334106,
0.27966251969337463,
-0.34701207280158997,
0.05869189277291298,
-0.1036512553691864,
-0.07576508074998856,
-0.08828817307949066,
-0.12188690900802612,
-0.11719073355197906,
0.4761338233947754,
-0.42300206422805786,
-0.6453847885131836,
-0.24698081612586975,
-0.10815702378749847,
0.3567081689834595,
-0.595159113407135,
0.04987957701086998,
0.14163871109485626,
-0.12419989705085754,
0.24225234985351562,
-0.12248330563306808,
0.0029180855490267277,
-0.4751432240009308,
0.058148834854364395,
0.29889950156211853,
1.0110543966293335,
-0.035618312656879425,
-0.21195274591445923,
-0.036559756845235825,
0.24604955315589905,
0.42505335807800293,
0.2406701147556305,
-0.5769285559654236,
-0.4650280475616455,
0.06884188205003738,
-0.26843002438545227,
0.3179599940776825,
0.23978501558303833,
-0.043126508593559265,
0.035684734582901,
-0.27285924553871155,
-0.08286424726247787,
0.03415142372250557,
-0.11789834499359131,
-0.5538007616996765,
0.07227781414985657,
0.08317916095256805,
0.27720871567726135,
0.09745702147483826,
0.40188848972320557,
-0.5951700210571289,
-0.38550296425819397,
-0.024721957743167877,
-0.47077125310897827,
0.44290390610694885,
-0.041883472353219986,
0.8236256837844849,
-0.22111660242080688,
-0.29364606738090515,
-0.23904737830162048,
-0.11648234724998474,
-0.3724736273288727,
0.307993620634079,
-0.8736504316329956,
1.51065993309021,
-0.15529626607894897,
-0.21147051453590393,
0.7076488733291626,
-0.046409524977207184,
0.1930992305278778,
0.30072590708732605,
-0.1487511545419693,
0.027329005300998688,
-0.031062381342053413,
-0.4315260052680969,
0.3074245750904083,
0.1517503261566162,
-0.10125197470188141,
-0.7262217998504639,
-0.06705167889595032,
0.25776177644729614,
-0.30665794014930725,
-0.4534730017185211,
-0.11925975978374481,
-0.31055203080177307,
0.24483977258205414,
-0.01791369915008545,
0.5210580825805664,
-0.34457555413246155,
-0.22239772975444794,
0.9718719124794006,
-0.1714625060558319,
0.7009971141815186,
0.45745888352394104,
0.24225039780139923,
0.49631041288375854,
0.45518171787261963,
0.42728757858276367,
0.40244555473327637,
-0.740358829498291,
0.25098806619644165,
0.3066926598548889,
0.3149126172065735,
-0.11372523009777069,
-0.2804572880268097,
-0.24380427598953247,
0.092806875705719,
-0.3379053473472595,
0.00000871798511070665,
-0.2800481915473938,
-0.23246896266937256,
0.45351502299308777,
-0.05838685855269432,
0.4923779368400574,
0.1659667044878006,
-0.2142924666404724,
-0.17271944880485535,
0.5435451865196228,
-0.8162095546722412,
-0.6600732207298279,
0.24385228753089905,
0.2110002189874649,
0.24903884530067444,
-0.03963160887360573,
-0.16359083354473114,
-0.13310396671295166,
-0.2169514298439026,
-0.6898439526557922,
0.354009747505188,
-0.18106070160865784,
0.36308321356773376,
-0.03268695995211601,
0.1411467045545578,
0.17520073056221008,
0.016321374103426933,
-0.6331883072853088,
-0.8752923607826233,
-0.8756493330001831,
0.5522782802581787,
0.5267884135246277,
0.49376198649406433,
0.09112932533025742,
-0.36700189113616943,
-0.15797288715839386,
0.11089958995580673,
-0.42797085642814636,
0.3781886398792267,
-0.1089678555727005,
-0.7089690566062927,
-0.43192681670188904,
-0.24071432650089264,
0.7882322072982788,
0.8958627581596375,
0.4242892265319824,
-0.21736028790473938,
-0.7016037106513977,
0.07921554148197174,
-0.14230580627918243,
-0.42581626772880554,
-0.17107141017913818,
0.12336783856153488,
0.1986173838376999,
-0.2607606053352356,
-0.48467567563056946,
0.6976492404937744,
0.7305766344070435,
-0.0405116081237793,
0.15029972791671753,
0.021575424820184708,
-0.041210100054740906,
-0.098833367228508,
0.4012177288532257,
0.08147651702165604,
-0.3149319291114807,
0.09367679059505463,
-0.45745986700057983,
-0.6870033740997314,
0.1264132261276245,
-6.1842780113220215,
-0.05017940327525139,
-0.6170152425765991,
-0.34283268451690674,
-0.3835030198097229,
-0.0800616666674614,
0.5914032459259033,
-0.09273691475391388,
-0.1519968956708908,
-0.17953217029571533,
0.23619863390922546,
0.18491967022418976,
0.12171980738639832,
0.6519455313682556,
0.37870365381240845,
0.35406771302223206,
0.3974812924861908,
-0.03250773623585701,
0.017082076519727707,
0.31693100929260254,
0.28561708331108093,
-0.2695416212081909,
-0.3146068751811981,
0.7199627757072449,
0.08002642542123795,
-0.0765652060508728,
-0.837510883808136,
0.18844252824783325,
-0.02992226742208004,
-0.14474764466285706,
0.31358081102371216,
0.030084023252129555,
-0.43740350008010864,
-0.1939069926738739,
0.7678876519203186,
0.40952956676483154,
0.5032441020011902,
0.18774081766605377,
0.34967851638793945,
-0.570360004901886,
0.32436496019363403,
0.6087068319320679,
-0.16089706122875214,
-0.13314411044120789,
0.4712197780609131,
0.16487477719783783,
-0.2199394255876541,
0.41975852847099304,
-0.44536152482032776,
0.3099997937679291,
-0.23990881443023682,
-0.038742344826459885,
-0.16733187437057495,
0.5638323426246643,
-0.016202861443161964,
-0.5222848653793335,
0.24461306631565094,
0.1414487361907959,
-0.3432137966156006,
0.2451578676700592,
-0.15630075335502625,
-0.43120595812797546,
0.06745857745409012,
-0.881205677986145,
-0.32919076085090637,
0.4487343430519104,
-0.6029849052429199,
-0.37805357575416565,
-0.242527037858963,
-0.01708039455115795,
-0.5140119791030884,
0.2149728238582611,
0.1496066451072693,
-0.4839600622653961,
0.41985490918159485,
-0.20950669050216675,
0.21482060849666595,
0.30933651328086853,
0.018233170732855797,
0.24397319555282593,
-0.3165730834007263,
-0.7218667268753052,
-0.00378340482711792,
0.02586173079907894,
0.24525317549705505,
-0.25808921456336975,
-0.056453775614500046,
-0.15018774569034576,
-0.0657406896352768,
0.22587279975414276,
0.7174807786941528,
-0.32606908679008484,
0.17999333143234253,
0.6740292906761169,
0.4583320617675781,
0.5385739803314209,
0.30779942870140076,
0.009912439621984959,
0.2514245808124542,
-0.47443750500679016,
0.19212225079536438,
-0.10097488015890121,
0.1113351434469223,
-0.6368417143821716,
0.04479989409446716,
0.2596145272254944,
-0.23912480473518372,
-0.16407902538776398,
0.6267665028572083,
-0.7855527400970459,
0.24764810502529144,
-0.5703728199005127,
-0.4513036608695984,
0.2875450551509857,
0.578542947769165,
0.006735145580023527,
-0.2836988568305969,
0.006150177679955959,
0.22651681303977966,
-0.1471838802099228,
0.1703416258096695,
-0.05508154630661011,
-0.42841818928718567,
0.04727115482091904,
-0.35685819387435913,
-0.42383113503456116,
0.14481757581233978,
0.3409566283226013,
-0.6271029710769653,
-0.15102316439151764,
0.40523239970207214,
0.5039198994636536,
-0.10187117010354996,
0.38919442892074585,
0.09081145375967026,
-0.41137564182281494,
-0.13277104496955872,
0.34778082370758057,
0.05178520083427429,
-0.7165956497192383,
0.5632463097572327,
0.21208274364471436,
-0.0759713277220726,
0.10988477617502213,
0.20347385108470917,
0.06502583622932434,
-0.18930388987064362,
0.018044473603367805,
-0.5147606730461121,
0.13576559722423553,
0.11043114215135574,
-0.24227182567119598,
-0.136485755443573,
-0.10254877060651779,
0.12949633598327637,
0.19280625879764557,
0.5689518451690674,
0.36590519547462463,
0.15292078256607056,
-0.24832460284233093,
0.10119858384132385,
0.1281031370162964,
-1.2002156972885132,
0.13492000102996826,
0.3236772418022156,
-0.15667691826820374,
-0.37525850534439087,
-0.32231712341308594,
0.2673948407173157,
0.19822177290916443,
0.31179752945899963,
-0.8593956828117371,
-0.5351568460464478,
-0.4198071360588074,
-0.17017535865306854,
-0.283698707818985,
0.01753622479736805,
0.11244074255228043,
-0.23238475620746613,
-0.01063920371234417,
-0.003481729654595256,
-0.5945585370063782,
-0.017345638945698738,
0.07377699017524719,
0.6446187496185303,
0.38205018639564514,
0.154639333486557,
0.005471991375088692,
-0.13797910511493683,
-0.24585185945034027,
0.2288437783718109,
0.48297959566116333,
0.2565561830997467,
0.24464625120162964,
-0.05918029695749283,
0.1640913337469101,
0.2875622510910034,
0.19810637831687927,
-0.1447761356830597,
-0.16956496238708496,
-0.1367097645998001,
0.1335381716489792,
-0.46714791655540466,
0.06734912842512131,
0.5256941318511963,
-0.45470529794692993,
-0.1364665925502777,
0.20194469392299652,
-0.13472789525985718,
-0.32511141896247864,
-0.6577125191688538,
-0.4115849733352661,
0.1604846864938736,
0.1212429404258728,
0.0617767870426178,
-0.1480768322944641,
0.27855294942855835,
0.0938427671790123,
-0.8520427942276001,
0.6014752388000488,
0.5206313133239746,
-0.17838934063911438,
-0.8476264476776123,
-0.4151836633682251,
-0.30593141913414,
-0.3522450923919678,
0.6095137596130371,
-0.46704238653182983,
0.07708927989006042,
0.15439334511756897,
-0.32355043292045593,
-0.008139071986079216,
0.15356957912445068,
0.5096429586410522,
0.21100343763828278,
-0.2660437822341919,
-0.6128180623054504,
0.5091419219970703,
0.14291732013225555,
-0.4167644679546356,
0.12187373638153076,
0.37776800990104675,
-0.08140618354082108,
-0.14372949302196503,
-0.05649368837475777,
0.42164933681488037,
0.017029939219355583,
-0.3398723900318146,
-0.4153469502925873,
0.048666294664144516,
0.3730817139148712,
0.0278917383402586,
-0.24012935161590576,
0.11868895590305328,
0.7040606141090393,
-0.062092412263154984,
-0.24508097767829895,
-0.4153168499469757,
0.017923587933182716,
0.42209917306900024,
0.1991768628358841,
-0.1283285766839981,
-0.29309985041618347,
-0.44408735632896423,
-0.06779367476701736,
-0.04303845763206482,
-0.2770073711872101,
-0.44157201051712036,
0.27389204502105713,
-0.35864970088005066,
0.19088053703308105,
0.1957053542137146,
-0.15034809708595276,
0.5540497303009033,
0.18343490362167358,
-0.24124856293201447,
0.01581805758178234,
0.15657447278499603,
-0.0674186423420906,
0.21418635547161102,
0.10519689321517944,
-0.23122245073318481,
0.22803831100463867,
-0.5302309393882751,
0.10794668644666672,
-0.25160396099090576,
0.3143826425075531,
-0.35423600673675537,
0.20337830483913422,
-0.09107928723096848,
-0.34797975420951843,
-0.1320318579673767,
-0.8350887298583984,
-0.4166404902935028,
-0.0818694531917572,
0.197810560464859,
0.492499440908432,
0.16973719000816345,
0.053352098912000656,
-0.1506383866071701,
-0.11866065859794617,
0.7071240544319153,
0.3394148349761963,
-0.6895299553871155,
-0.2736797034740448,
0.2588243782520294,
0.15959487855434418,
-0.08930324018001556,
-0.1620168685913086,
0.18344737589359283,
0.2838694155216217,
0.06187724322080612,
0.3758273422718048,
0.6287757158279419,
-0.13847041130065918,
0.11249670386314392,
0.14915241301059723,
-0.08926458656787872,
0.44819697737693787,
0.49597516655921936,
0.09717459231615067,
0.0724736824631691,
0.6707555651664734,
-0.3124121427536011,
-0.255321741104126,
0.4083729684352875,
0.023213986307382584,
0.12535354495048523,
0.2879501283168793,
0.5820564031600952,
0.25616520643234253,
0.4086347818374634,
-0.0767923891544342,
0.5772974491119385,
0.3546697199344635,
-0.04833914712071419,
0.3655960261821747,
-0.006788529921323061,
-0.20926198363304138,
0.3003689646720886,
0.7798556685447693,
-0.11567456275224686,
0.05823202803730965,
0.04089691862463951,
-0.25595948100090027,
-0.024314401671290398,
-0.2878687083721161,
0.22911059856414795,
-0.8076234459877014,
-0.12623324990272522,
0.16745224595069885,
0.27751678228378296,
0.03615779057145119,
0.02227623574435711,
0.11194238066673279,
-0.4315603971481323,
0.2856304347515106,
-0.3369339108467102,
-0.6808949708938599,
0.24304671585559845,
0.17015016078948975,
0.41273683309555054,
0.14105992019176483,
-0.09798406064510345,
-0.2566533386707306,
-0.15697890520095825,
0.554407000541687,
0.5233747959136963,
-0.13393187522888184,
-0.06505938619375229,
-0.4709722697734833,
0.2422522008419037,
-0.18843653798103333,
0.12816889584064484,
-0.4240354299545288,
-0.46171945333480835,
0.2997737526893616,
-0.35443007946014404,
0.1555638164281845,
0.09048613160848618,
0.2075376808643341,
0.32828086614608765,
-0.42990830540657043,
-0.34826043248176575,
0.21943549811840057,
-0.29208704829216003,
0.18713492155075073,
0.5530802607536316,
0.20118911564350128,
0.07088521867990494,
0.13345959782600403,
-0.6354539394378662,
-0.0796138197183609,
0.3617688715457916,
-0.30688148736953735,
-0.21318042278289795,
-0.5028483271598816,
0.8925501108169556,
0.5915619730949402,
0.02044784463942051,
-0.00915105827152729,
-0.11348406970500946,
-0.16550205647945404,
0.5065709948539734,
-0.5338446497917175,
0.009333173744380474,
-0.6077659130096436,
-0.37345415353775024,
-0.5698325634002686,
-0.37972474098205566,
0.44262000918388367,
-0.027459602802991867,
-0.27660372853279114,
-0.33995378017425537,
0.4657353460788727,
0.3606206178665161,
0.11687091737985611,
-0.5354536771774292,
-0.11023902893066406,
-0.24007578194141388,
-0.1775394231081009,
-0.2855495810508728,
0.7169184684753418,
0.028711944818496704,
0.3843013644218445,
0.23478001356124878,
-0.19436967372894287,
-0.09318278729915619,
-0.3605397641658783,
0.14371928572654724,
-0.15166880190372467,
-0.11897240579128265,
-0.3446783125400543,
0.5254191160202026,
-0.612978458404541,
-0.5534489750862122,
0.060952845960855484,
0.1920308768749237,
0.27128830552101135,
-0.43623340129852295,
-0.40233612060546875,
-0.2015666514635086,
0.446911096572876,
0.47718557715415955,
-0.16065841913223267,
0.14537732303142548,
-0.3327900767326355,
-0.33013004064559937,
-0.3383479416370392,
0.16743548214435577,
0.030491121113300323,
0.11762932687997818,
-0.26380595564842224,
0.03887386620044708,
0.040411487221717834,
0.06861750036478043,
-0.0034305693116039038,
-0.5107288956642151,
-0.06002860516309738,
-0.22717387974262238
] |
Objective. —To examine more closely the association between apolipoprotein E (APOE) genotype and Alzheimer disease (AD) by age and sex in populations of various ethnic and racial denominations. Data Sources. —Forty research teams contributed data onAPOEgenotype, sex, age at disease onset, and ethnic background for 5930 patients who met criteria for probable or definite AD and 8607 controls without dementia who were recruited from clinical, community, and brain bank sources. Main Outcome Measures. —Odds ratios (ORs) and 95% confidence intervals (Cls) for AD, adjusted for age and study and stratified by major ethnic group (Caucasian, African American, Hispanic, and Japanese) and source, were computed forAPOEgenotypes ∈2/∈2,∈2/∈3,∈2/∈4,∈3/∈4 and ∈4/∈4 relative to the ∈3/∈3 group. The influence of age and sex on the OR for each genotype was assessed using logistic regression procedures. Results. —Among Caucasian subjects from clinic- or autopsy-based studies, the risk of AD was significantly increased for people with genotypes ∈2/∈4 (OR=2.6, 95% Cl=1.6-4.0), ∈3/∈4 (OR=3.2, 95% Cl=2.8-3.8), and ∈4/∈4 (OR=14.9, 95% CI=10.8-20.6); whereas, the ORs were decreased for people with genotypes ∈2/∈2 (OR=0.6, 95% Cl=0.2-2.0) and ∈2/∈3 (OR=0.6, 95% Cl=0.5-0.8). TheAPOE∈4-AD association was weaker among African Americans and Hispanics, but there was significant heterogeneity in ORs among studies of African Americans (P Conclusions. —TheAPOE∈4 allele represents a major risk factor for AD in all ethnic groups studied, across all ages between 40 and 90 years, and in both men and women. The association betweenAPOE∈4 and AD in African Americans requires clarification, and the attenuated effect ofAPOE∈4 in Hispanics should be investigated further. | [
-0.011770961806178093,
0.017466994002461433,
-0.01629817485809326,
0.013067446649074554,
0.003687626216560602,
0.01643524318933487,
0.008621019311249256,
0.005354182794690132,
-0.009542837738990784,
0.02130156382918358,
0.004858558066189289,
0.0057142991572618484,
-0.009027248248457909,
0.021830879151821136,
0.017454389482736588,
0.0016154299955815077,
-0.024025648832321167,
0.0016968919662758708,
0.009957325644791126,
0.010802499949932098,
0.026238352060317993,
0.009121391922235489,
0.008458205498754978,
0.0006683103274554014,
-0.019410595297813416,
-0.012980561703443527,
0.016130242496728897,
-0.029912389814853668,
0.017104309052228928,
-0.023973174393177032,
0.018069494515657425,
0.008900947868824005,
-0.029384471476078033,
0.024665161967277527,
0.0018563041230663657,
-0.013536827638745308,
0.003110718447715044,
0.011207847855985165,
0.019098933786153793,
-0.005550537258386612,
-0.009720003232359886,
-0.008257378824055195,
0.005896547343581915,
-0.0005874643102288246,
-0.00567783135920763,
0.00901990756392479,
-0.00798417441546917,
0.007462653331458569,
-0.002032284624874592,
0.007030019070953131,
-0.012987341731786728,
0.008997409604489803,
-0.016198022291064262,
-0.0038982215337455273,
-0.0049145701341331005,
-0.005341680720448494,
0.01573614962399006,
0.00036798231303691864,
-0.0139714190736413,
0.019542308524250984,
-0.01735895685851574,
-0.02578657865524292,
-0.00495885917916894,
-0.020894262939691544,
-0.027896925806999207,
-0.0675189271569252,
0.009496885351836681,
0.004570435732603073,
0.006844853516668081,
-0.0228900033980608,
-0.0038032173179090023,
0.014073885045945644,
0.011312018148601055,
-0.0072538163512945175,
-0.0007426510564982891,
-0.008028519339859486,
0.006078554317355156,
-0.012072143144905567,
0.0269569531083107,
0.016378803178668022,
0.0037414112593978643,
0.002816336927935481,
0.033336520195007324,
0.012139696627855301,
-0.026699213311076164,
-0.004063433036208153,
-0.022670619189739227,
0.005156590603291988,
0.006057416088879108,
-0.007070955354720354,
-0.0017307964153587818,
-0.022356197237968445,
-0.011955234222114086,
0.0026644954923540354,
-0.018371369689702988,
-0.005275610834360123,
-0.0011483270209282637,
0.013317915610969067,
-0.030340030789375305,
-0.031541693955659866,
-0.015555700287222862,
-0.008036525920033455,
0.025470156222581863,
0.035858333110809326,
0.00875780452042818,
0.01227665413171053,
-0.028317958116531372,
0.0196987334638834,
0.05107937380671501,
0.006256693974137306,
-0.01573251746594906,
-0.006288489792495966,
-0.01758776791393757,
0.006352526135742664,
-0.0037980652414262295,
0.03403422608971596,
-0.0027835897635668516,
0.009304095059633255,
0.004406025633215904,
0.00408993661403656,
0.007357369177043438,
-0.008086091838777065,
-0.006182531826198101,
-0.0026351872365921736,
-0.0026141852140426636,
-0.006969911511987448,
0.024503029882907867,
-0.0000357374083250761,
0.014314481988549232,
-0.010863066650927067,
-0.0033065006136894226,
-0.014528083615005016,
-0.017964065074920654,
0.01896507479250431,
0.0013783578760921955,
-0.0016457526944577694,
-0.011100959032773972,
0.01866505853831768,
-0.01376473717391491,
-0.00798720121383667,
-0.006373574957251549,
0.00974374357610941,
0.008786777965724468,
0.004318081308156252,
0.008748097345232964,
0.001447073183953762,
0.012788696214556694,
-0.0037886560894548893,
0.0086177047342062,
-0.010535253211855888,
0.004070206545293331,
-0.00788651593029499,
-0.0013558840146288276,
-0.01619592495262623,
0.04049510508775711,
0.00951296091079712,
-0.0038417053874582052,
0.0057310382835567,
0.003294155467301607,
0.02594868838787079,
-0.009151136502623558,
0.022830449044704437,
0.009533102624118328,
0.008556263521313667,
0.011849547736346722,
0.005045442841947079,
0.017359133809804916,
-0.012367326766252518,
-0.020851457491517067,
0.0032620374113321304,
-0.0010405165376141667,
0.015156096778810024,
0.01472838781774044,
0.006351168733090162,
0.0006658853963017464,
-0.00922037847340107,
-0.008975699543952942,
0.005482614506036043,
-0.010646633803844452,
0.06702502071857452,
-0.024409882724285126,
-0.016979942098259926,
-0.026436656713485718,
0.03771936893463135,
-0.0014722137711942196,
-0.01142224483191967,
-0.00769585557281971,
-0.005228875204920769,
0.02051180601119995,
-0.027586009353399277,
-0.0006817136891186237,
0.007472184952348471,
0.006161489058285952,
-0.008349144831299782,
-0.019881252199411392,
0.0022095926105976105,
-0.004451246932148933,
0.0073083508759737015,
-0.00425990205258131,
-0.014161002822220325,
-0.022522367537021637,
-0.013916973024606705,
0.01224111020565033,
0.01080980896949768,
-0.003197416430339217,
0.010307534597814083,
0.030711939558386803,
-0.012063770554959774,
-0.007543197367340326,
0.002861449494957924,
0.014539815485477448,
-0.005135063081979752,
-0.0026154492516070604,
-0.014317788183689117,
-0.00860714539885521,
-0.0216512568295002,
0.013723512180149555,
0.01354460883885622,
-0.004205223638564348,
-0.013588421046733856,
-0.0007515732431784272,
-0.0062118712812662125,
-0.0026880321092903614,
0.0024384623393416405,
0.011555975303053856,
-0.026892460882663727,
0.005335037596523762,
0.007483874447643757,
0.004825731739401817,
-0.019720181822776794,
0.006299293600022793,
-0.02248377352952957,
-0.009152872487902641,
0.016993209719657898,
-0.0036092926748096943,
0.015176992863416672,
0.010745524428784847,
0.004397728480398655,
0.009207644499838352,
-0.003411052515730262,
-0.01898322068154812,
-0.027140581980347633,
0.008645717054605484,
-0.011544209904968739,
0.010113127529621124,
0.0006480356678366661,
0.009716172702610493,
0.005765935406088829,
-0.011922755278646946,
-0.007360059302300215,
0.0038389749825000763,
-0.005167786497622728,
0.024059373885393143,
-0.0012275222688913345,
0.002290746197104454,
-0.008617658168077469,
-0.026296649128198624,
-0.04839213937520981,
0.022213974967598915,
-0.032268330454826355,
0.0034611565060913563,
0.0060150823555886745,
-0.01792033389210701,
0.007320814300328493,
-0.03717925399541855,
-0.0036803330294787884,
-0.0023227997589856386,
0.018351508304476738,
0.0008231841493397951,
-0.03256827965378761,
0.007234491407871246,
-0.007089550606906414,
-0.00012743512343149632,
-0.08173485845327377,
-0.006710343062877655,
-0.006734284106642008,
-0.018010951578617096,
0.002218620153144002,
0.02064432203769684,
0.007641545496881008,
0.006535618100315332,
0.0016899170586839318,
-0.028066210448741913,
0.025368068367242813,
-0.019862106069922447,
-0.009179865941405296,
0.0008450141176581383,
-0.024465391412377357,
0.010959943756461143,
0.0038568510208278894,
0.011814616620540619,
-0.026936888694763184,
-0.02169996313750744,
0.017729120329022408,
0.0032468808349221945,
0.009814986027777195,
-0.005994775332510471,
-0.005990086123347282,
-0.0038153883069753647,
-0.004618094768375158,
0.003045969409868121,
-0.016944553703069687,
-0.0032350285910069942,
-0.03366173803806305,
-0.02038862742483616,
0.010044570080935955,
-0.005501581821590662,
-0.012086072936654091,
0.004853096790611744,
-0.006557118147611618,
-0.017564279958605766,
-0.0010425514774397016,
0.013322211802005768,
-0.007898127660155296,
0.012684984132647514,
0.009019088000059128,
-0.007991866208612919,
0.016869358718395233,
-0.01178664155304432,
0.011626334860920906,
0.008209357038140297,
0.02134713903069496,
-0.012776961550116539,
0.0036691492423415184,
-0.0064418925903737545,
0.011278850957751274,
0.009814806282520294,
-0.004807152319699526,
0.0023745878133922815,
-0.010189141146838665,
0.017561644315719604,
-0.00949539802968502,
-0.004093038849532604,
-0.026978593319654465,
-0.016628041863441467,
0.0010886103846132755,
-0.005062876734882593,
0.009899656288325787,
0.010137990117073059,
0.011505262926220894,
-0.008412349037826061,
0.0002961063291877508,
0.01838848926126957,
0.027056343853473663,
-0.008185421116650105,
-0.0018771797185763717,
-0.00771293556317687,
0.0007158038788475096,
-0.010876577347517014,
-0.012403707951307297,
0.0035214023664593697,
0.017115913331508636,
0.005092780105769634,
-0.009499752894043922,
-0.005874030292034149,
-0.022464796900749207,
-0.015630118548870087,
-0.013731718063354492,
-0.013029530644416809,
0.010741738602519035,
0.017429601401090622,
0.012048917822539806,
-0.0057705724611878395,
0.01642415300011635,
0.034378886222839355,
-0.00002079363912343979,
0.011682828888297081,
0.0052328333258628845,
0.02704775519669056,
0.005467384122312069,
0.018275253474712372,
-0.015584392473101616,
0.006356111727654934,
0.02392938919365406,
-0.0013062756042927504,
-0.021829258650541306,
-0.007903851568698883,
-0.0224820114672184,
0.014224616810679436,
-0.005068427883088589,
0.011650195345282555,
-0.001101087313145399,
0.0014793367590755224,
-0.007348944433033466,
-0.020704399794340134,
-0.005495578981935978,
0.017772385850548744,
0.004889529198408127,
-0.016581978648900986,
-0.013034781441092491,
-0.008694485761225224,
0.07298319041728973,
-0.004963749088346958,
-0.0008629679214209318,
-0.0228592362254858,
0.0023249266669154167,
-0.016415387392044067,
-0.015713540837168694,
-0.02099744603037834,
-0.0206211619079113,
-0.01924370601773262,
0.010016795247793198,
-0.0012045688927173615,
0.03549935668706894,
-0.020328745245933533,
-0.03155186399817467,
-0.004243244417011738,
-0.00859010498970747,
-0.0025219679810106754,
0.009231950156390667,
-0.008759275078773499,
-0.03814518451690674,
-0.001763831009157002,
-0.03281856328248978,
-0.020264841616153717,
0.0003327857702970505,
0.0003511052345857024,
-0.02840147539973259,
-0.014376741833984852,
-0.011718256399035454,
0.011030290275812149,
0.021795686334371567,
-0.006737495772540569,
-0.007036760915070772,
0.0025037683080881834,
-0.004522508010268211,
0.003808930516242981,
0.02372497320175171,
0.01570281758904457,
0.015515965409576893,
-0.020021334290504456,
-0.03434979170560837,
-0.007981271483004093,
0.0011344749946147203,
0.0032323580235242844,
-0.032716646790504456,
0.000684086699038744,
0.013754344545304775,
-0.0035913512110710144,
-0.008497004397213459,
-0.0044675227254629135,
0.006173121742904186,
-0.000958046643063426,
0.014693303033709526,
-0.0007103611715137959,
0.018689734861254692,
-0.008505703881382942,
-0.0038407505489885807,
-0.012035897932946682,
-0.004035272169858217,
-0.0006329932948574424,
-0.04109698161482811,
-0.0017242729663848877,
0.012111546471714973,
-0.017296232283115387,
-0.020441297441720963,
-0.003500872291624546,
0.00018317252397537231,
-0.014660974964499474,
-0.0005973749794065952,
0.024597449228167534,
0.023871833458542824,
0.002928338944911957,
-0.007895582355558872,
-0.025322604924440384,
-0.018593575805425644,
-0.02460063062608242,
-0.008402323350310326,
-0.026398316025733948,
-0.009150620549917221,
-0.01641925796866417,
0.020262081176042557,
0.017885390669107437,
-0.01790975034236908,
0.015561170876026154,
0.0022630980238318443,
-0.01752554252743721,
-0.0266877468675375,
-0.07512946426868439,
-0.01031813770532608,
0.009535596705973148,
-0.006991728208959103,
-0.013894736766815186,
0.027465425431728363,
-0.012702442705631256,
-0.0013062519719824195,
0.002559238811954856,
-0.0047316113486886024,
-0.0034132597502321005,
-0.022982273250818253,
-0.009198116138577461,
-0.0027694301679730415,
0.008871611207723618,
0.017345096915960312,
-0.018552342429757118,
-0.003907575272023678,
0.007982723414897919,
0.024975556880235672,
0.03764854744076729,
0.018473684787750244,
-0.020800404250621796,
0.0008448995649814606,
-0.016044795513153076,
-0.08179526031017303,
-0.007881824858486652,
-0.010635343380272388,
0.017661700025200844,
0.009660860523581505,
-0.011598309502005577,
0.01635526679456234,
0.0035847676917910576,
0.023388762027025223,
-0.016007181257009506,
0.01385444588959217,
-0.00198105676099658,
0.004725123755633831,
-0.032673221081495285,
-0.029505137354135513,
-0.0013341557933017612,
0.016602851450443268,
0.003208242589607835,
-0.018035471439361572,
0.027259204536676407,
-0.0153605742380023,
0.021890124306082726,
-0.0006959591992199421,
0.0071070222184062,
-0.004864176269620657,
-0.011181479319930077,
-0.01102188415825367,
0.01483965665102005,
0.012512743473052979,
-0.016364580020308495,
0.013847192749381065,
-0.017770107835531235,
-0.015825098380446434,
-0.02018965594470501,
-0.02366809919476509,
-0.023890124633908272,
-0.0037112256977707148,
-0.017626989632844925,
0.03232936933636665,
-0.004822060000151396,
-0.002263689413666725,
-0.014943926595151424,
-0.0014162107836455107,
0.007340132258832455,
-0.017123408615589142,
0.005424495320767164,
0.00798865221440792,
-0.007134940475225449,
-0.004263963550329208,
-0.004133005626499653,
0.01040707714855671,
-0.01151149533689022,
0.005973123013973236,
0.016932372003793716,
0.017223209142684937,
0.010598343797028065,
-0.0031712804920971394,
0.008988883346319199,
0.008501442149281502,
0.0022938961628824472,
0.00267590070143342,
0.007283659651875496,
0.011479916051030159,
0.07258866727352142,
-0.01766686514019966,
0.00584240909665823,
-0.019945824518799782,
-0.00044333934783935547,
0.0012256773188710213,
0.002370055764913559,
-0.00810864008963108,
-0.0016898945905268192,
-0.016828108578920364,
-0.01275989692658186,
-0.0021082470193505287,
-0.01148531399667263,
0.008567717857658863,
0.012039382942020893,
0.0045928386971354485,
0.005574353970587254,
-0.010318798944354057,
-0.0026493286713957787,
-0.016980662941932678,
-0.011128973215818405,
0.039808422327041626,
-0.002800229238346219,
0.0112814512103796,
-0.005112334154546261,
0.0034915327560156584,
0.006284055300056934,
-0.011985881254076958,
-0.034946758300065994,
0.009153110906481743,
0.0011158259585499763,
-0.026598142459988594,
0.007001239340752363,
-0.015526535920798779,
0.017533326521515846,
0.01311846449971199,
0.0044785612262785435,
0.012882143259048462,
0.0002645370550453663,
-0.015207048505544662,
-0.007280916906893253,
-0.016624007374048233,
0.002391338348388672,
-0.016845766454935074,
0.016868993639945984,
-0.02582661248743534,
0.012242255732417107,
0.015196302905678749,
0.0030980221927165985,
0.0107691939920187,
0.006662576459348202,
0.005314243026077747,
-0.00038797222077846527,
-0.001478991936892271,
-0.007767111994326115,
-0.008490929380059242,
-0.014133989810943604,
0.01456962525844574,
0.004466386511921883,
0.003039201255887747,
0.00361841544508934,
-0.006544389761984348,
-0.006431328132748604,
-0.02094373106956482,
-0.008188372477889061,
0.00010640372056514025,
0.005670380778610706,
-0.010893715545535088,
0.009040983393788338,
0.011052193120121956,
-0.028179343789815903,
0.00036607752554118633,
0.0031213131733238697,
0.00441017746925354,
0.007968071848154068,
-0.002469811588525772,
-0.010777631774544716,
0.006586846895515919,
0.006709970533847809,
0.007848777808248997,
-0.0018613660940900445,
0.015151379629969597,
0.00006643356755375862,
0.0051208846271038055,
-0.0004276377148926258,
0.009103696793317795,
-0.01744181476533413,
0.00808195024728775,
0.0027721766382455826,
0.0037062731571495533,
0.007260450627654791,
0.011708397418260574,
0.002861529588699341,
0.03066161274909973,
0.0057243602350354195,
0.032665520906448364,
0.015634333714842796,
-0.002270954428240657,
-0.009736749343574047,
-0.012991044670343399,
0.0028953496366739273,
0.001167472219094634,
-0.020388174802064896,
0.0005071018822491169,
-0.007717203814536333,
0.0016229052562266588,
-0.0038618517573922873,
-0.00818189699202776,
-0.007873977534472942,
-0.0038550379686057568,
-0.005115852691233158,
-0.002902868902310729,
0.02565915137529373,
0.0074559953063726425,
0.014792649075388908,
0.002553842030465603,
0.005212295334786177,
-0.017010066658258438,
0.003948980011045933,
-0.01591920480132103,
-0.027619685977697372,
-0.02611079439520836,
0.005062825977802277,
0.014733838848769665,
-0.014611836522817612,
-0.0038285749033093452,
-0.008270161226391792,
0.027996357530355453,
0.009687945246696472,
-0.002464374527335167,
0.029543235898017883,
-0.022527329623699188,
0.00023388199042528868,
0.017803296446800232,
0.008337954059243202,
0.006940601859241724,
0.006672166753560305,
-0.0032992330379784107,
0.010910570621490479,
-0.004486745223402977,
0.0008763237856328487,
-0.009226230904459953,
0.0029453870374709368,
0.005486318841576576,
0.00764178391546011,
-0.01495666615664959,
0.013166376389563084,
0.03069772943854332,
0.006088761612772942,
0.016992885619401932,
0.002442691707983613,
0.00517674395814538,
-0.0041905418038368225,
-0.0031825038604438305,
0.008764739148318768,
-0.002997132483869791,
0.006101776380091906,
0.0012046884512528777,
0.0014065324794501066,
-0.02366022765636444,
0.00016329926438629627,
-0.017543980851769447,
-0.00005010340828448534,
0.004270074889063835,
-0.0007825787179172039,
-0.0024716677144169807,
-0.014237986877560616,
0.016995199024677277,
-0.011043423786759377,
0.010036639869213104,
0.01288648322224617,
0.00667085824534297,
-0.0007065092213451862,
0.01623903587460518,
-0.02093842253088951,
0.0011451997561380267,
0.00014649191871285439,
0.006056235171854496,
-0.010152055881917477,
0.01708250865340233,
0.010576948523521423,
0.0031643814872950315,
0.0025951596908271313,
-0.007085525896400213,
-0.0010321340523660183,
-0.011463039554655552,
-0.00015962019097059965,
0.014791720546782017,
0.005009773653000593,
0.03190407529473305,
-0.007476803380995989,
0.006551958620548248,
-0.019803470000624657,
-0.006869746837764978,
-0.018115723505616188,
-0.0007403241470456123,
0.0111156664788723,
-0.000429798848927021,
-0.003791871014982462,
0.015498334541916847,
0.022166959941387177,
0.014085594564676285
] | [
0.31899183988571167,
0.1943778246641159,
0.2733822464942932,
0.126759335398674,
0.0038275369442999363,
0.7021290063858032,
0.34896060824394226,
-0.02146948128938675,
0.11370347440242767,
-0.32643675804138184,
0.2560522258281708,
0.4924054443836212,
-0.1720249503850937,
0.0386049784719944,
0.13292640447616577,
1.00917387008667,
0.38453245162963867,
0.03610130026936531,
-0.05352368205785751,
-0.5480539798736572,
-0.3160386085510254,
-0.5464138388633728,
-0.006720425095409155,
-0.07414015382528305,
0.1384267956018448,
0.3927497863769531,
0.3207812011241913,
-0.32964959740638733,
-0.33774062991142273,
-0.2957429885864258,
-0.013308320194482803,
0.6890498995780945,
-0.16319037973880768,
-0.1375192552804947,
-0.2368619590997696,
0.32545846700668335,
0.2431783676147461,
0.23917832970619202,
0.16731081902980804,
-0.49676597118377686,
-0.13822436332702637,
-0.29690733551979065,
-0.015160656534135342,
0.37195050716400146,
-0.6851441264152527,
-0.6481564044952393,
-1.5277602672576904,
0.07471279799938202,
-0.6225763559341431,
0.41296347975730896,
0.3160265386104584,
0.43942341208457947,
0.04379671439528465,
0.49075838923454285,
-0.16361010074615479,
0.650325357913971,
0.10312701016664505,
-0.17929896712303162,
0.20274998247623444,
-0.23356811702251434,
0.3693125545978546,
-0.14543816447257996,
0.39076006412506104,
0.11045905202627182,
-0.17949780821800232,
-0.06276021152734756,
-0.058673400431871414,
0.2028963714838028,
-0.33886265754699707,
-0.2518985867500305,
-0.19120751321315765,
-0.37614989280700684,
-0.49971383810043335,
0.24935244023799896,
-0.36417528986930847,
-0.27981653809547424,
-0.34248510003089905,
-0.08567916601896286,
0.41693592071533203,
-0.13219405710697174,
0.5960994958877563,
-0.012179545126855373,
0.07123047858476639,
-0.5078882575035095,
0.22894321382045746,
0.43684065341949463,
0.26488617062568665,
0.271725594997406,
-0.44300323724746704,
0.29825225472450256,
0.02544858120381832,
-0.4043218791484833,
0.3756289482116699,
0.6640602350234985,
0.07187638431787491,
0.3154539465904236,
0.4692681133747101,
-0.4713347554206848,
0.06383576989173889,
-0.005770963151007891,
-0.10944349318742752,
0.11694690585136414,
-0.0764763206243515,
0.03703594207763672,
-0.7485136389732361,
0.3710344135761261,
0.01239775586873293,
-0.7451103925704956,
-0.8680397272109985,
-0.020120570436120033,
-0.8854214549064636,
0.5981908440589905,
-0.25245893001556396,
-0.27602165937423706,
-0.3476976156234741,
-0.11007556319236755,
0.2894521653652191,
-0.3323165774345398,
0.14702549576759338,
0.2154851108789444,
-0.149568572640419,
0.6970469951629639,
-0.42630642652511597,
-0.19761186838150024,
0.101605623960495,
0.15335260331630707,
0.1947719305753708,
0.3141127824783325,
0.21091237664222717,
0.4799538552761078,
-0.24807097017765045,
-0.12582625448703766,
-0.18357235193252563,
0.12465404719114304,
-0.013548605144023895,
-0.5539942383766174,
0.008678464218974113,
0.17447207868099213,
0.1982143074274063,
-0.2236560881137848,
-0.5258039236068726,
-1.1723705530166626,
-0.16098856925964355,
-0.38500699400901794,
0.4690868556499481,
-0.3842315077781677,
0.1961958110332489,
0.06447869539260864,
-0.20424863696098328,
0.18207888305187225,
0.0976889431476593,
0.14257436990737915,
-0.4791741371154785,
-0.536675214767456,
0.15974974632263184,
0.5612199902534485,
-0.16968941688537598,
-0.5253090858459473,
-0.1236642524600029,
0.1584390103816986,
0.6798019409179688,
0.4228785037994385,
-0.4092932343482971,
-0.2932451367378235,
0.5422607660293579,
-0.03438182920217514,
-0.037044599652290344,
0.5158736109733582,
-0.18910816311836243,
-0.29102009534835815,
-0.2309044450521469,
-0.4897593855857849,
0.29469195008277893,
-0.20658554136753082,
-0.6612116098403931,
0.26432061195373535,
0.43290919065475464,
0.3367229998111725,
0.23071220517158508,
0.12786366045475006,
-0.43365544080734253,
0.18890106678009033,
0.1493508666753769,
-0.6764352917671204,
-0.3390408158302307,
-0.3044240474700928,
0.4505036771297455,
-0.1902366578578949,
0.587319016456604,
0.3528789281845093,
0.1715441793203354,
-0.40324488282203674,
0.4239939749240875,
-0.8275510668754578,
0.9197815656661987,
-0.9330605864524841,
-0.6983379125595093,
0.8785422444343567,
0.37118443846702576,
-0.40972810983657837,
0.4029998779296875,
-0.08901370316743851,
0.3347285985946655,
-0.34380394220352173,
-0.2971850335597992,
0.08095967024564743,
0.08548742532730103,
-0.2540166676044464,
-0.6448202133178711,
0.4552188217639923,
0.18719148635864258,
-0.08255443722009659,
-0.33245646953582764,
-0.09818124771118164,
0.254951149225235,
-0.13347500562667847,
0.10445066541433334,
0.18546125292778015,
-0.14593957364559174,
-0.1363562047481537,
0.6421694755554199,
-0.38195812702178955,
0.20945169031620026,
0.2041831910610199,
-0.19009274244308472,
0.2792080342769623,
0.44623807072639465,
-0.14116217195987701,
0.7408408522605896,
-0.7702836394309998,
0.5572138428688049,
0.10398536175489426,
0.3449666202068329,
-0.25416427850723267,
-0.06276678293943405,
0.16953711211681366,
-0.1911783069372177,
0.04712999239563942,
0.6284825205802917,
0.001146500464528799,
-0.21055904030799866,
-0.03256150335073471,
-0.286590576171875,
-0.02419428899884224,
-0.12317246198654175,
-0.34985998272895813,
-0.2902587950229645,
0.23578879237174988,
-0.9599436521530151,
0.22430971264839172,
0.02908608503639698,
-0.31605204939842224,
0.04721188545227051,
0.09930849075317383,
0.5805603265762329,
-0.06465144455432892,
0.24249131977558136,
-0.5115607380867004,
-0.08285456150770187,
-0.07174934446811676,
-0.33894672989845276,
-0.019168436527252197,
0.4041886627674103,
-0.22731411457061768,
0.7555474042892456,
-0.792965829372406,
-0.6093583703041077,
-0.4856393039226532,
0.22753441333770752,
0.6852352619171143,
0.8135408163070679,
0.3422553837299347,
-0.17450767755508423,
0.4097702205181122,
0.21025565266609192,
-0.2510407865047455,
0.3969929814338684,
0.7349734902381897,
-0.8967971801757812,
-0.06054540351033211,
0.10488367825746536,
-0.10464338213205338,
0.6070473790168762,
-0.036785393953323364,
0.184999480843544,
-0.3647318184375763,
0.053764935582876205,
-0.6739912033081055,
-0.4340243935585022,
-0.0654882937669754,
-0.23233287036418915,
0.6506801247596741,
0.037772662937641144,
-0.8186854720115662,
0.6027061939239502,
0.3137241005897522,
0.0362095944583416,
0.44692155718803406,
0.2758413255214691,
-0.1076759621500969,
-0.04016416519880295,
0.35206836462020874,
0.17985738813877106,
-0.20183220505714417,
0.3578304946422577,
0.06112128868699074,
-0.11687663197517395,
0.25683534145355225,
-6.071974754333496,
0.054098181426525116,
-0.951807975769043,
-0.07178143411874771,
-0.251931369304657,
-0.040966350585222244,
0.9256932139396667,
-0.03125076740980148,
0.0632636621594429,
-0.21925558149814606,
0.6083804965019226,
0.07397132366895676,
0.14734575152397156,
0.4855462908744812,
0.266488254070282,
0.42787620425224304,
0.14630791544914246,
0.1397836059331894,
-0.009120950475335121,
0.38615694642066956,
-0.19800332188606262,
-0.6517720222473145,
0.022581588476896286,
0.36038705706596375,
0.3320561647415161,
0.23278501629829407,
-0.9368734359741211,
0.4787524342536926,
0.33860039710998535,
-0.1712997853755951,
0.6217705011367798,
-0.49669748544692993,
-0.3559008538722992,
-0.4164741337299347,
0.5385518074035645,
0.3197699189186096,
0.4145708382129669,
0.21941016614437103,
0.4365667998790741,
-0.5631634593009949,
0.20777031779289246,
0.08830533921718597,
-0.24569931626319885,
-0.6171489953994751,
0.06580749154090881,
-0.1399639993906021,
0.24267953634262085,
0.5517266392707825,
-0.44301989674568176,
0.043978072702884674,
0.02905726060271263,
0.20853760838508606,
0.04999876394867897,
0.5609360337257385,
0.2011907547712326,
-0.41543149948120117,
0.03639431670308113,
0.5098556280136108,
-0.460697203874588,
0.5160164833068848,
0.3823358714580536,
0.00976286455988884,
-0.07960540056228638,
-0.3346983790397644,
-0.5053446292877197,
0.25934237241744995,
-0.22428885102272034,
-0.18671807646751404,
0.25645649433135986,
-0.0987638309597969,
-0.031069232150912285,
-0.1691526621580124,
0.2294669896364212,
-0.5172457098960876,
-0.21011875569820404,
-0.26590731739997864,
0.6128841042518616,
0.29736530780792236,
-0.0528867207467556,
-0.09818493574857712,
-0.4837993085384369,
-0.5440170168876648,
0.15962345898151398,
-0.05784009024500847,
0.39680299162864685,
0.2693314254283905,
0.008713037706911564,
0.3929792642593384,
-0.4812321364879608,
0.07764535397291183,
-0.20952996611595154,
-0.2005239576101303,
0.21071182191371918,
0.6786593198776245,
0.15119461715221405,
0.3427387475967407,
0.7107143402099609,
0.32749906182289124,
0.5053176283836365,
-0.12495697289705276,
0.8821221590042114,
0.028675725683569908,
-0.247670978307724,
-0.9194015860557556,
-0.3006684482097626,
0.029398955404758453,
-0.6130180954933167,
-0.3471139967441559,
1.06253182888031,
-1.0889707803726196,
0.12322079390287399,
0.15817320346832275,
0.21598194539546967,
-0.11935721337795258,
0.69888836145401,
-0.08129744231700897,
-0.1994807869195938,
-0.14202150702476501,
0.37762150168418884,
-0.05220678448677063,
0.05227723345160484,
0.2587905824184418,
-0.3225477933883667,
0.16942952573299408,
-0.4780406951904297,
-0.13685674965381622,
0.2588336169719696,
0.40865471959114075,
-0.9837336540222168,
0.017836766317486763,
0.29818829894065857,
0.5063285231590271,
-0.3219446539878845,
0.16707390546798706,
0.04762577265501022,
-0.3212588131427765,
-0.07783757150173187,
0.4573158323764801,
0.3138602375984192,
-0.1711406409740448,
0.9330893158912659,
-0.07363489270210266,
-0.15691961348056793,
0.27398183941841125,
-0.11063184589147568,
0.07619152218103409,
-0.28161635994911194,
-0.14835798740386963,
-0.19907011091709137,
-0.15805143117904663,
0.2941432297229767,
0.2130676507949829,
0.3572256863117218,
-0.0015884290914982557,
-0.450066477060318,
0.10227377712726593,
0.353575199842453,
-0.3298174738883972,
-0.359571635723114,
-0.7165685892105103,
0.423944890499115,
0.027869047597050667,
-1.0411577224731445,
-0.3939039409160614,
-0.0021368814632296562,
-0.029509497806429863,
-0.11327949911355972,
0.15005214512348175,
-0.07295647263526917,
0.1732180118560791,
0.2482946813106537,
-0.5528327226638794,
-0.1603882908821106,
-0.07163438200950623,
0.0424966998398304,
0.08373747766017914,
-0.7807343006134033,
-0.07628292590379715,
-0.031359635293483734,
-0.05833074450492859,
0.08367323130369186,
-0.5552738308906555,
-0.31220850348472595,
0.10818777233362198,
0.8256322741508484,
0.23618896305561066,
0.04692670330405235,
0.09899715334177017,
-0.0877443328499794,
0.08696558326482773,
-0.14786426723003387,
-0.3001002371311188,
0.4584188461303711,
0.0667373314499855,
-0.2437584400177002,
-0.2220248132944107,
0.21309638023376465,
0.04636608809232712,
-0.03374902158975601,
-0.008752282708883286,
0.1145917996764183,
0.20833539962768555,
-0.28828689455986023,
0.10656970739364624,
0.228603795170784,
-0.27985167503356934,
-0.07948001474142075,
-0.11034373193979263,
-0.20381705462932587,
0.06913979351520538,
-0.27731209993362427,
-0.5115188956260681,
-0.39106935262680054,
0.19504334032535553,
-0.3859546184539795,
0.26022928953170776,
-0.220222607254982,
-0.3089730739593506,
-0.10961851477622986,
0.3363051116466522,
0.7996008396148682,
-0.04386734962463379,
-0.19197872281074524,
0.16880859434604645,
-0.22825691103935242,
-0.01778050884604454,
0.65074622631073,
-0.8880040645599365,
-0.0986637994647026,
0.2893507182598114,
-0.6488974094390869,
0.0868702307343483,
0.012173284776508808,
0.5191888213157654,
-0.1457362025976181,
-0.21412846446037292,
-0.6619117259979248,
0.2017304003238678,
0.22901636362075806,
-0.25144827365875244,
-0.3974084258079529,
0.5298515558242798,
-0.4113710820674896,
-0.15108147263526917,
0.172993466258049,
0.34943535923957825,
-0.040157515555620193,
-0.15065811574459076,
-0.29191288352012634,
0.10125468671321869,
-0.30636170506477356,
-0.7352755665779114,
0.14494174718856812,
0.06272200495004654,
0.3898307979106903,
-0.08852267265319824,
0.2629505693912506,
-0.09303443133831024,
-0.0948808416724205,
0.025801748037338257,
-0.31294742226600647,
-0.5233563780784607,
0.03401532024145126,
-0.07561852037906647,
-0.04904424026608467,
0.05203130096197128,
-0.1542891263961792,
-0.26275867223739624,
0.25753286480903625,
-0.026544036343693733,
0.29131725430488586,
0.1493602991104126,
0.4052278995513916,
0.6745251417160034,
-0.06325635313987732,
-0.11209088563919067,
0.09563147276639938,
0.2654394805431366,
-0.1663931906223297,
-0.03169994428753853,
-0.31565505266189575,
-0.19972260296344757,
0.47555145621299744,
-0.059177398681640625,
0.13675366342067719,
-0.6451613903045654,
0.3043328523635864,
0.12832093238830566,
-0.17682617902755737,
-0.3499188721179962,
0.03171510994434357,
0.26272711157798767,
-0.509210467338562,
-0.4793224036693573,
-0.3009597063064575,
0.48114776611328125,
0.1350562870502472,
0.613064706325531,
0.23510555922985077,
-0.13410526514053345,
-0.18935105204582214,
0.7332137823104858,
0.26751983165740967,
-0.3764050602912903,
-0.05149494484066963,
0.21889467537403107,
0.2648938298225403,
-0.2602289021015167,
-0.014615452848374844,
-0.03546474128961563,
0.4371904134750366,
-0.014078399166464806,
0.49694138765335083,
0.796730637550354,
-0.3293578326702118,
0.04654458165168762,
-0.4983602464199066,
-0.410867840051651,
0.8929884433746338,
0.6291512846946716,
-0.3955518305301666,
0.5775060057640076,
0.8851123452186584,
-0.07429447025060654,
-0.10563332587480545,
0.20542800426483154,
0.0961986854672432,
0.507834255695343,
0.008107991889119148,
0.6292415261268616,
0.6252826452255249,
0.30799898505210876,
-0.1372997909784317,
0.49515125155448914,
-0.13524550199508667,
-0.026371367275714874,
-0.08102039992809296,
-0.4317935109138489,
-0.2858690619468689,
0.018816854804754257,
0.8620164394378662,
0.1930817812681198,
-0.13243980705738068,
-0.362359881401062,
-0.09455184638500214,
0.4707925021648407,
-0.4120279848575592,
0.30600228905677795,
-0.6401050686836243,
0.3741958439350128,
0.14260561764240265,
-0.29943612217903137,
-0.033640582114458084,
-0.21214519441127777,
-0.4134121835231781,
-0.21445941925048828,
-0.011023652739822865,
-0.07268653064966202,
-0.683776319026947,
0.10656934231519699,
0.04458979517221451,
0.23866158723831177,
0.09189335256814957,
-0.10110696405172348,
-0.3189932107925415,
-0.6695488691329956,
0.4633071720600128,
0.24841709434986115,
0.02613532356917858,
0.17823675274848938,
-0.5320011973381042,
0.0905345156788826,
-0.4068175256252289,
0.3060337007045746,
-0.15154467523097992,
-0.476058691740036,
0.04208467900753021,
-0.11044884473085403,
0.09236349910497665,
0.2174244225025177,
-0.34556490182876587,
-0.551734209060669,
-0.026874607428908348,
-0.4752519130706787,
-0.04667377099394798,
-0.34755513072013855,
-0.3158183991909027,
0.2131507694721222,
0.12279164791107178,
0.1961209923028946,
0.21203449368476868,
-0.32700467109680176,
0.20573095977306366,
0.030130382627248764,
-0.43743765354156494,
-0.23711153864860535,
-0.28878089785575867,
0.08071710914373398,
0.19818855822086334,
-0.010701065883040428,
-0.36454275250434875,
0.4389009475708008,
0.14190082252025604,
0.10646848380565643,
0.021437078714370728,
0.36149391531944275,
-0.29991593956947327,
-0.16895584762096405,
-0.38797271251678467,
-0.07389448583126068,
0.19894853234291077,
-0.09302053600549698,
-0.5203579664230347,
0.2964458167552948,
-0.2320251166820526,
0.310737282037735,
0.19198395311832428,
-0.1497146040201187,
-0.09921462088823318,
0.13578946888446808,
-0.07003884762525558,
-0.11991120129823685,
0.2660377025604248,
0.04178352653980255,
-0.5189234018325806,
0.31870830059051514,
0.051250554621219635,
0.08553903549909592,
-0.06824168562889099,
0.4196804463863373,
-0.39204007387161255,
-0.2330315262079239,
-0.3736551105976105,
0.25571179389953613,
-0.7032015919685364,
-0.11164570599794388,
0.39806222915649414,
0.16398392617702484,
0.046264223754405975,
-0.26585665345191956,
-0.709014356136322,
-0.30203816294670105,
0.502773642539978,
0.19236156344413757,
0.33868709206581116,
0.3797887861728668,
0.3378497064113617,
-0.4169068932533264,
-0.4320093095302582,
0.3829157054424286,
-0.2965143024921417,
-0.24769018590450287,
-0.05038416013121605,
0.0321684256196022,
-0.510248064994812,
0.09238769859075546,
0.19767901301383972,
-0.29094675183296204,
0.057975299656391144,
-0.1543111652135849
] |
Glioblastoma (GBM) is the most aggressive and common form of brain cancer in adults. GBM is characterized by poor survival and remarkably high tumors heterogeneity (both intertumoral and intratumoral), and lack of effective therapies. Recent high-throughput data revealed heterogeneous genetic/genomic/epigenetic features and led to multiple methods aiming to classify tumors according to the key molecular events that drive the most aggressive cellular components so that targeted therapies can be developed for individual subtypes. However, GBM molecular subtypes have not led to improvement of patients outcomes. Targeted or tailored therapies for specific mutations or subtypes largely failed due to the complexities arising from intratumoral molecular heterogeneity. Most tumors develop resistance to treatment and soon recur. GBM stem cells (GSCs) have been identified. Recent single cell sequencing studies of GBM suggest that intratumoral cellular heterogeneity can be partially explained by tumor cell hierarchy arising from GBM stem cells. Therefore, the molecular subtypes based on patient derived GSCs may potentially lead to more effective subtype-specific treatments. In this paper, we review the molecular alterations of GBM and molecular subtyping methods as well as subtype plasticity in primary and recurrent tumors emphasizing the clinical relevance of potential targets for further drug development. | [
-0.017776967957615852,
-0.00392370717599988,
-0.013192860409617424,
0.017409946769475937,
0.010227171704173088,
-0.014570327475667,
0.010304508730769157,
0.018801184371113777,
-0.01116087008267641,
0.0023629621136933565,
-0.014943896792829037,
0.017828484997153282,
0.009937535971403122,
0.017563512548804283,
-0.02047344297170639,
0.01006278395652771,
-0.019991736859083176,
0.030195536091923714,
0.009801095351576805,
0.011656798422336578,
0.005652138963341713,
-0.017080718651413918,
0.009535223245620728,
-0.005687925964593887,
0.001488594338297844,
0.0033063809387385845,
-0.036987852305173874,
0.009856817312538624,
-0.028837043792009354,
0.004506269469857216,
-0.00009081698954105377,
0.011008194647729397,
0.031911447644233704,
-0.0020457380451261997,
0.002886232454329729,
-0.014907626435160637,
-0.0017707465449348092,
0.01987745426595211,
-0.009223919361829758,
-0.0035718996077775955,
0.019607631489634514,
-0.01077074185013771,
-0.00021229818230494857,
-0.03187565878033638,
-0.01151779294013977,
0.01461847499012947,
-0.0010672751814126968,
0.005814533680677414,
0.007538298144936562,
0.016529325395822525,
-0.01765810325741768,
-0.020634431391954422,
-0.01161867193877697,
0.002621226478368044,
-0.006116820033639669,
0.005365283228456974,
0.01864810660481453,
-0.00893229991197586,
0.01437455415725708,
0.0038112932816147804,
0.015065370127558708,
-0.0021699825301766396,
-0.009804883040487766,
-0.02253616601228714,
-0.031289875507354736,
-0.06702988594770432,
0.03553513064980507,
-0.010961941443383694,
-0.009720923379063606,
-0.005863204598426819,
-0.004115869291126728,
0.004496056120842695,
0.026252832263708115,
-0.013137328438460827,
-0.022870521992444992,
0.0027366401627659798,
-0.026855124160647392,
-0.006235672626644373,
-0.007789934054017067,
0.021577155217528343,
-0.005601482931524515,
-0.0016633110353723168,
-0.010993584990501404,
0.030103623867034912,
-0.010137422010302544,
0.014307713136076927,
-0.035963162779808044,
-0.036216866225004196,
0.029336458072066307,
-0.007728409022092819,
0.019906755536794662,
-0.02498144842684269,
-0.026289544999599457,
-0.00415720185264945,
-0.0325285866856575,
-0.014436713419854641,
-0.018320361152291298,
-0.003191241528838873,
-0.01293436624109745,
-0.020398970693349838,
-0.0228206105530262,
0.020670484751462936,
0.011602137237787247,
-0.014143376611173153,
-0.0027721207588911057,
0.005462563596665859,
0.004739479627460241,
0.008617289364337921,
0.011468233540654182,
0.013297921977937222,
-0.0009439494460821152,
-0.003096858272328973,
0.000048609450459480286,
-0.012448787689208984,
-0.002502312185242772,
0.012501793913543224,
0.009228112176060677,
0.008866634219884872,
0.0032903607934713364,
0.010951343923807144,
0.026173129677772522,
0.0024782917462289333,
-0.008579094894230366,
-0.007451482117176056,
0.001692541758529842,
-0.022780928760766983,
0.010375872254371643,
-0.0015448019839823246,
0.02205534838140011,
-0.007729023694992065,
-0.008848605677485466,
0.021737711504101753,
-0.0131670031696558,
-0.004415553994476795,
-0.01970522105693817,
-0.01001714263111353,
-0.055797770619392395,
-0.003631027415394783,
0.0029442673549056053,
-0.0025746915489435196,
-0.0062821414321660995,
0.009254511445760727,
0.008518174290657043,
0.010505760088562965,
0.021959930658340454,
0.005535200238227844,
-0.009571408852934837,
0.006591871380805969,
0.0031266044825315475,
-0.03686044365167618,
-0.006119990721344948,
0.0051947664469480515,
-0.01890019327402115,
0.001504375133663416,
0.015657052397727966,
-0.013531215488910675,
-0.016506925225257874,
-0.01555711217224598,
-0.0034829778596758842,
0.00393788143992424,
0.01778196543455124,
-0.021505923941731453,
0.019961288198828697,
0.007944628596305847,
0.008265433833003044,
-0.0282436590641737,
0.0035942145623266697,
-0.015634139999747276,
-0.00616390909999609,
0.012156078591942787,
-0.013197469525039196,
-0.014436532743275166,
0.0301644466817379,
0.018068477511405945,
0.00791812315583229,
-0.0026371621061116457,
0.021899733692407608,
0.007885084487497807,
-0.00377338333055377,
0.06678636372089386,
-0.031252555549144745,
0.021590957418084145,
-0.022068198770284653,
-0.01057109422981739,
0.008965741842985153,
0.0145416846498847,
-0.012791766785085201,
-0.005312521010637283,
-0.025365324690937996,
0.012005896307528019,
0.024404969066381454,
0.03679222613573074,
0.009248577989637852,
0.008119178004562855,
-0.004422459285706282,
0.0032880210783332586,
0.009761341847479343,
-0.006584626622498035,
-0.007484192959964275,
0.00924875121563673,
0.03849584981799126,
-0.013952162116765976,
0.02169029787182808,
-0.0063643548637628555,
-0.010696779005229473,
0.014638258144259453,
0.01385233923792839,
-0.008105544373393059,
-0.014846283942461014,
-0.006731431931257248,
0.01744592748582363,
-0.019625931978225708,
-0.024936968460679054,
-0.0037864563055336475,
0.014978569000959396,
-0.01731126382946968,
-0.0037671681493520737,
0.014348672702908516,
-0.012465961277484894,
-0.011799551546573639,
0.002011615317314863,
-0.014686700887978077,
-0.023965612053871155,
0.0015602112980559468,
0.011180015280842781,
-0.014802852645516396,
0.008634960278868675,
0.007712705992162228,
0.0026875464245676994,
0.0003741231048479676,
-0.005825442727655172,
-0.01489681750535965,
-0.012662545777857304,
0.003022379707545042,
0.028324780985713005,
0.056187622249126434,
0.01199319027364254,
-0.022002488374710083,
0.00918147899210453,
-0.01745142973959446,
0.01829804666340351,
0.005624464713037014,
0.014550397172570229,
-0.010340371169149876,
0.01650250516831875,
-0.0038272333331406116,
0.0037377383559942245,
0.012185750529170036,
-0.005469011142849922,
-0.016024384647607803,
0.0077789556235075,
0.006562207825481892,
0.007922508753836155,
-0.002933880314230919,
0.004050606396049261,
0.014243558049201965,
-0.009275661781430244,
-0.0008745458908379078,
0.022536393254995346,
0.0024117478169500828,
0.011710386723279953,
0.008694235235452652,
0.000995604321360588,
0.036035388708114624,
-0.036651406437158585,
0.000994658563286066,
0.020631680265069008,
0.02183505706489086,
-0.015397652983665466,
0.011129255406558514,
0.004768194630742073,
-0.014735741540789604,
0.007279908284544945,
-0.08110150694847107,
-0.01371353305876255,
0.0064605847001075745,
-0.007358470931649208,
0.008192405104637146,
0.007350155618041754,
0.02146109752357006,
-0.006296961568295956,
-0.014109238050878048,
-0.01912335306406021,
-0.00253937765955925,
-0.003853841917589307,
-0.0036211952101439238,
0.017831414937973022,
0.023025549948215485,
-0.014806700870394707,
0.011242855340242386,
-0.04346925765275955,
-0.00229214527644217,
-0.031725089997053146,
0.022029917687177658,
0.0011827033013105392,
0.03051832504570484,
0.003164580324664712,
-0.01566256396472454,
0.01562199555337429,
0.007637965027242899,
0.009114441461861134,
-0.0029035615734755993,
0.012276733294129372,
-0.004540775436908007,
0.0019544840324670076,
0.0037651406601071358,
-0.0009900059085339308,
0.0032594408839941025,
-0.02927362732589245,
0.009579099714756012,
0.0017444088589400053,
-0.010466229170560837,
-0.0023824952077120543,
-0.02212970145046711,
0.008936221711337566,
0.003974934108555317,
-0.020190970972180367,
0.006104362662881613,
0.026565568521618843,
-0.03951052576303482,
-0.029625680297613144,
0.015217390842735767,
0.0054821474477648735,
-0.011843902990221977,
0.01185531448572874,
0.038078732788562775,
0.005908999126404524,
-0.018258605152368546,
0.00755326496437192,
-0.008256778120994568,
-0.010109726339578629,
-0.013406727463006973,
-0.019874760881066322,
0.0154107129201293,
0.0013293717056512833,
-0.013871951960027218,
0.01736731454730034,
0.005508830770850182,
0.011791320517659187,
0.017998645082116127,
-0.0034992913715541363,
-0.01450195349752903,
-0.004549106582999229,
0.000010111136361956596,
-0.014543326571583748,
0.010254837572574615,
-0.012636496685445309,
-0.0008098985999822617,
0.0008802732336334884,
-0.016949467360973358,
-0.0023155473172664642,
-0.012516297399997711,
0.0015775910578668118,
0.01294619869440794,
0.010746742598712444,
-0.004015820100903511,
0.00455639511346817,
-0.015129235573112965,
-0.015435966663062572,
0.0020376346074044704,
0.036498889327049255,
0.013453980907797813,
-0.02109639346599579,
-0.002902634907513857,
0.04434001445770264,
-0.027996443212032318,
0.014611499384045601,
-0.0015439337585121393,
-0.022024761885404587,
0.00453545805066824,
0.016050295904278755,
0.028763148933649063,
0.008627282455563545,
-0.010072087869048119,
-0.0005624920595437288,
0.02641327865421772,
-0.01573864370584488,
-0.012358332052826881,
0.019405249506235123,
0.018716394901275635,
-0.008145350031554699,
0.005755577236413956,
-0.006658010184764862,
0.008371630683541298,
0.02789333462715149,
-0.0021608113311231136,
0.013761937618255615,
0.020891457796096802,
0.019983023405075073,
-0.010481132194399834,
-0.012964730150997639,
0.07225093990564346,
0.008679616264998913,
0.01009044423699379,
-0.025540143251419067,
0.01740303263068199,
-0.029914015904068947,
-0.026096593588590622,
0.029186299070715904,
-0.032487984746694565,
-0.031026165932416916,
0.010486376471817493,
0.0008517405949532986,
0.04711221531033516,
-0.008967659436166286,
-0.010621386580169201,
0.02826758287847042,
0.008928756229579449,
0.021658016368746758,
-0.002598618157207966,
-0.01814660243690014,
-0.010078462772071362,
-0.007791371084749699,
-0.0392058789730072,
0.01376232411712408,
0.002069141250103712,
-0.02174580842256546,
-0.006795487366616726,
-0.012684311717748642,
0.0025886946823447943,
0.010979295708239079,
0.02160097099840641,
-0.00002363068051636219,
-0.008986873552203178,
0.024933507665991783,
0.012058587744832039,
0.008532537147402763,
0.005883493460714817,
-0.006160474382340908,
0.016454394906759262,
-0.011604862287640572,
-0.023941224440932274,
-0.01591632328927517,
0.0234089195728302,
0.01877673715353012,
-0.049625612795352936,
-0.0012337267398834229,
0.010403968393802643,
-0.0030587315559387207,
-0.015072471462190151,
0.0056664529256522655,
0.0019690231420099735,
-0.014878659509122372,
0.0038982476107776165,
0.039849814027547836,
0.0017483956180512905,
-0.01328418031334877,
0.018016228452324867,
-0.02034365013241768,
0.0081618782132864,
-0.015023795887827873,
-0.0328734889626503,
-0.003010498359799385,
0.003463340923190117,
0.013995815068483353,
0.012920686975121498,
-0.014769334346055984,
0.009770197793841362,
-0.006372719071805477,
0.03329046443104744,
-0.0007244711741805077,
0.021327003836631775,
-0.017943337559700012,
-0.02306945249438286,
0.03269851207733154,
0.005310374312102795,
0.02874317392706871,
-0.00942337978631258,
-0.008260361850261688,
0.008661720901727676,
-0.009569919668138027,
0.0010569607838988304,
-0.0006312429904937744,
0.013814290054142475,
-0.014662399888038635,
0.015043825842440128,
0.007845170795917511,
-0.010871199890971184,
-0.0738404393196106,
-0.009321268647909164,
-0.01598372682929039,
-0.0011059686075896025,
0.012049920856952667,
-0.012649617157876492,
-0.0059869131073355675,
-0.0063270749524235725,
-0.019908661022782326,
-0.008119778707623482,
0.0025360677391290665,
-0.0006361124105751514,
-0.0038891760632395744,
0.023300180211663246,
0.013107135891914368,
0.021281521767377853,
-0.007862480357289314,
-0.019892297685146332,
-0.006439307238906622,
0.0236089825630188,
-0.013633696362376213,
0.06709284335374832,
0.005996314808726311,
0.007535618729889393,
-0.020136121660470963,
-0.08125202357769012,
0.02054264023900032,
-0.02308029681444168,
-0.006707129068672657,
-0.012271092273294926,
-0.01256696879863739,
-0.01767002046108246,
0.00301057705655694,
-0.020640458911657333,
-0.017136437818408012,
0.01816709339618683,
0.005229882895946503,
0.012508734129369259,
0.008203480392694473,
-0.021348992362618446,
-0.013265024870634079,
0.0336979404091835,
-0.03367257118225098,
-0.021912887692451477,
-0.008296497166156769,
-0.015948228538036346,
0.006956304423511028,
-0.007576625328511,
-0.009284554980695248,
-0.012181158177554607,
-0.004113932605832815,
0.009655727073550224,
0.016715671867132187,
0.02131662890315056,
0.004652025178074837,
0.007684862241148949,
-0.00029595824889838696,
0.005442840047180653,
-0.005070353392511606,
-0.02817995473742485,
-0.018988274037837982,
0.009116511791944504,
-0.019239338114857674,
0.013134142383933067,
0.0014129243791103363,
-0.0074572754092514515,
0.02504226379096508,
0.028204085305333138,
0.007036774419248104,
-0.018353445455431938,
0.008641576394438744,
0.00603673979640007,
-0.008558996953070164,
-0.01023903489112854,
0.022148456424474716,
0.007971624843776226,
-0.019237160682678223,
0.014799131080508232,
-0.014078767970204353,
0.015883905813097954,
-0.006460961885750294,
-0.004682246595621109,
0.0042578899301588535,
0.02092621475458145,
0.0201368797570467,
-0.00508303614333272,
0.03199286013841629,
0.0010185381397604942,
0.071910560131073,
0.007399121765047312,
0.01824331283569336,
0.006886870600283146,
-0.011752486228942871,
0.006969028618186712,
-0.03261256963014603,
0.0042193857952952385,
-0.01334800012409687,
0.0031153587624430656,
0.02379174716770649,
-0.009174471721053123,
0.003803817555308342,
0.01674708165228367,
-0.027263831347227097,
-0.018468260765075684,
-0.004968670196831226,
0.0027190018445253372,
-0.016855794936418533,
0.00014949124306440353,
0.033638909459114075,
0.019164059311151505,
-0.011496307328343391,
0.00013321754522621632,
-0.005747949704527855,
-0.0068816374987363815,
-0.025435615330934525,
0.02725346013903618,
-0.006640681065618992,
0.004377646371722221,
-0.004325540736317635,
0.020406577736139297,
0.007181722670793533,
0.005595175549387932,
0.00012285710545256734,
0.003977631218731403,
-0.026638269424438477,
0.0027614268474280834,
-0.001626837532967329,
-0.00581010989844799,
-0.0036382442340254784,
0.0005002333782613277,
0.0013711618958041072,
-0.03201743960380554,
0.0163407139480114,
-0.01752987690269947,
-0.012065790593624115,
0.028151826933026314,
-0.009014366194605827,
0.01092131994664669,
-0.00033906614407896996,
0.0015508080832660198,
0.016652554273605347,
0.01651645638048649,
0.009141327813267708,
0.031964726746082306,
-0.022487811744213104,
0.009430630132555962,
-0.02337765134871006,
0.017122309654951096,
0.01776837930083275,
-0.01691712811589241,
-0.002458618488162756,
-0.010222690179944038,
-0.0023811617866158485,
-0.00021012220531702042,
0.0015840823762118816,
-0.012034544721245766,
-0.00004906742833554745,
0.01575923152267933,
0.029609989374876022,
-0.0020567048341035843,
0.00958872027695179,
-0.015844611451029778,
-0.014661344699561596,
0.0016164565458893776,
0.01023870799690485,
-0.002655107993632555,
0.01595683954656124,
0.004738957621157169,
-0.004922260995954275,
-0.029629558324813843,
-0.013634474016726017,
-0.00021304981783032417,
0.016407398506999016,
0.023281773552298546,
0.010646691545844078,
-0.01712838001549244,
-0.010904675349593163,
0.0037062158808112144,
0.0458730086684227,
-0.008178803138434887,
0.009106582030653954,
0.010248272679746151,
0.013048611581325531,
0.033202432096004486,
0.021110882982611656,
0.003526119515299797,
-0.006317444145679474,
0.018472392112016678,
0.014191263355314732,
-0.00854402594268322,
-0.018510326743125916,
-0.04046999663114548,
-0.0063437968492507935,
-0.009109335951507092,
0.01291772723197937,
-0.015273360535502434,
0.014108303003013134,
0.0025343596935272217,
-0.0047356435097754,
0.0028291787020862103,
0.009937240742146969,
-0.006471994332969189,
-0.006297080311924219,
0.014583691954612732,
-0.006317309103906155,
0.0038571078330278397,
0.006395828444510698,
-0.018152568489313126,
-0.008835739456117153,
-0.021185459569096565,
-0.0030186004005372524,
0.05238514766097069,
0.01334415189921856,
-0.004219552502036095,
-0.015368446707725525,
0.006042789202183485,
-0.0431273989379406,
-0.010035179555416107,
0.017853859812021255,
-0.06851436197757721,
0.02544546127319336,
0.034537173807621,
-0.014758843928575516,
0.009290698915719986,
-0.014659633859992027,
0.0045951129868626595,
-0.02066734991967678,
0.006051772274076939,
0.01017110887914896,
-0.001340831397101283,
-0.0008501836564391851,
-0.009772527031600475,
0.009357430040836334,
-0.011713100597262383,
0.01123987976461649,
0.03759673982858658,
0.013407218270003796,
-0.010326692834496498,
-0.0013839140301570296,
-0.00021124770864844322,
-0.02502785064280033,
-0.01192933227866888,
-0.021053075790405273,
0.023107394576072693,
-0.005081230774521828,
0.024387724697589874,
0.034518130123615265,
0.035560257732868195,
-0.01100399810820818,
-0.020310167223215103,
-0.008607659488916397,
-0.008907957002520561,
0.00245068222284317,
0.015584154054522514,
-0.01754269003868103,
-0.03018992580473423,
-0.009439237415790558,
0.000018792226910591125,
0.02196204662322998,
0.021516554057598114,
-0.019965127110481262,
0.008172264322638512,
-0.03927749767899513,
0.006548609118908644,
-0.018757948651909828,
-0.007276113145053387,
-0.005128942895680666,
-0.014178531244397163,
-0.01286720484495163,
0.018617285415530205,
0.0005549674388021231,
-0.008110003545880318,
-0.017020437866449356,
0.005548185668885708,
-0.003754071891307831,
0.004339437000453472,
0.007096141576766968,
-0.01278778538107872,
0.005798435304313898,
-0.00335985841229558,
-0.00724397785961628,
0.014600684866309166,
0.009805687703192234,
-0.003882207442075014,
0.024297453463077545,
0.018467973917722702,
0.0014626274351030588,
-0.01597292721271515,
0.015776870772242546,
-0.007676267065107822
] | [
-0.18663236498832703,
0.28848958015441895,
0.3415268659591675,
0.012277636677026749,
0.3306271433830261,
-0.04496445134282112,
0.19438329339027405,
0.523856520652771,
-0.24782365560531616,
-0.2840653955936432,
-0.37886232137680054,
0.06501743942499161,
-0.8084319233894348,
0.3241744935512543,
-0.24737754464149475,
0.7063537836074829,
0.856593906879425,
0.1286010593175888,
-0.34530678391456604,
-0.3682098686695099,
-0.3256136178970337,
-0.7812622785568237,
0.6251673102378845,
0.15211188793182373,
0.43735942244529724,
-0.23852859437465668,
0.20423699915409088,
0.48239606618881226,
-0.19929395616054535,
0.17258766293525696,
-0.020792005583643913,
0.5151882171630859,
0.3580898940563202,
0.3314646780490875,
0.254451721906662,
0.36335939168930054,
-0.30317121744155884,
-0.16167737543582916,
0.03096221573650837,
-0.19419679045677185,
0.13840822875499725,
0.2211320400238037,
-0.5027258992195129,
0.4612622559070587,
-0.35524481534957886,
0.11647669970989227,
-1.3675117492675781,
0.8421455025672913,
-0.3783796429634094,
-0.17186640202999115,
0.19465333223342896,
0.376468688249588,
0.32347920536994934,
0.21027608215808868,
0.2648085057735443,
-0.10465020686388016,
-0.1931201070547104,
0.1206413134932518,
-0.057890668511390686,
-0.5232914090156555,
0.265931099653244,
-0.17706625163555145,
-0.46981102228164673,
0.04641356319189072,
-0.0784459114074707,
-0.016841711476445198,
-0.02654803730547428,
-0.13896264135837555,
-0.7376103401184082,
-0.07394662499427795,
-0.10169503092765808,
-0.29281195998191833,
0.34322884678840637,
0.60855633020401,
-0.6035611629486084,
0.27985092997550964,
0.04804152622818947,
-0.5625588297843933,
0.4532260298728943,
-0.41102397441864014,
-0.036981213837862015,
-0.0899689570069313,
0.39202913641929626,
0.4490342438220978,
-0.2473784238100052,
0.2268354892730713,
-0.16229213774204254,
1.0171515941619873,
-0.11901857703924179,
0.10998228192329407,
-0.037289418280124664,
-0.1669549196958542,
0.3697776794433594,
0.4228006601333618,
0.4689287543296814,
0.2403174638748169,
0.43103528022766113,
-0.18047651648521423,
0.00806350912898779,
-0.17003455758094788,
-0.014357584528625011,
0.020817618817090988,
0.2190687358379364,
0.034517161548137665,
-0.4164092540740967,
-0.29885202646255493,
-0.22088077664375305,
-0.2229064553976059,
-0.2987324893474579,
-0.011363942176103592,
-1.079796552658081,
-0.008247174322605133,
-0.27705490589141846,
-0.23377464711666107,
-0.2534897029399872,
0.25547394156455994,
-0.26440364122390747,
-0.1724749654531479,
0.04387008771300316,
-0.10347889363765717,
0.009253269992768764,
0.5161504149436951,
-0.9225338697433472,
-0.16923747956752777,
0.026029346510767937,
-0.048690587282180786,
0.16135817766189575,
0.2531183362007141,
-0.2087128758430481,
0.32000643014907837,
0.16218629479408264,
0.23034527897834778,
-0.1468035876750946,
-0.5018435716629028,
0.40305018424987793,
-0.3163509964942932,
0.26982033252716064,
0.017106249928474426,
0.4972684681415558,
0.058794211596250534,
-0.14916707575321198,
-1.1001945734024048,
-0.6530281901359558,
-0.09069125354290009,
0.4105112552642822,
-0.7514109015464783,
-0.008451924659311771,
-0.04857706278562546,
-0.0663503110408783,
-0.35058069229125977,
-0.07782968878746033,
0.3111230432987213,
-0.9988040924072266,
-0.19696563482284546,
0.2298728972673416,
0.28129756450653076,
-0.10767029970884323,
-0.736312747001648,
0.19867582619190216,
-0.05908292904496193,
0.11908728629350662,
-0.31249895691871643,
-0.5312181711196899,
-0.40012019872665405,
0.2259039431810379,
-0.3618885278701782,
0.5728039145469666,
0.026775900274515152,
-0.5305414795875549,
-0.156400665640831,
-0.4958755373954773,
-0.43243882060050964,
0.20110207796096802,
-0.24148090183734894,
-0.026369977742433548,
0.15533187985420227,
0.4821341633796692,
0.10649527609348297,
0.7840691208839417,
-0.13141407072544098,
-0.7143374085426331,
-0.07085320353507996,
0.3958631455898285,
0.1385561227798462,
0.41222208738327026,
-0.11009551584720612,
0.41235703229904175,
0.018279964104294777,
0.2522238492965698,
-0.18349775671958923,
-0.1055556982755661,
-0.42651817202568054,
0.7249877452850342,
-0.2748717665672302,
1.2035821676254272,
-0.23509067296981812,
-0.014498685486614704,
0.5571774244308472,
-0.3136897683143616,
-0.1406882405281067,
0.013541986234486103,
0.3760073482990265,
0.49505284428596497,
-0.4238799512386322,
-0.6700025200843811,
-0.21514272689819336,
-0.07248255610466003,
-0.4111064374446869,
0.028611544519662857,
0.08600640296936035,
0.6794286966323853,
-0.7782482504844666,
-0.24964496493339539,
0.006494814995676279,
0.592399537563324,
-0.37492066621780396,
-0.24133361876010895,
0.028570013120770454,
-0.4607779085636139,
-0.39865171909332275,
0.26906096935272217,
-0.719543993473053,
-0.07909040153026581,
0.5280433893203735,
0.14594633877277374,
1.1187820434570312,
0.21115349233150482,
-0.07159259915351868,
0.7312754988670349,
-0.3314100503921509,
0.5554853081703186,
0.2647034823894501,
0.305682510137558,
-0.1195109412074089,
-0.3424359858036041,
0.42778387665748596,
0.051909323781728745,
-0.383597195148468,
0.03315531834959984,
-0.19968995451927185,
-0.051524240523576736,
-0.0760192945599556,
-0.774183988571167,
-0.07770761102437973,
0.09228403121232986,
-0.7329522967338562,
-0.7100379467010498,
0.03203112259507179,
-0.7432390451431274,
0.013228780589997768,
0.14867088198661804,
0.35123392939567566,
0.17943963408470154,
-0.16713938117027283,
0.3408649265766144,
0.24225851893424988,
0.15827204287052155,
-0.15843519568443298,
-0.30287423729896545,
-0.46405571699142456,
-0.571398138999939,
0.0893482193350792,
-0.18662793934345245,
-0.014847254380583763,
-0.9310706853866577,
-0.1285582035779953,
-0.13461008667945862,
-0.0537409670650959,
0.30030959844589233,
0.5037741661071777,
0.28564387559890747,
0.24124814569950104,
-0.45652690529823303,
0.15730918943881989,
-0.22714465856552124,
-0.6054640412330627,
0.4284982979297638,
0.38205647468566895,
-0.6375191807746887,
0.012955721467733383,
-0.016438154503703117,
0.7802674770355225,
0.6699485778808594,
-0.12926797568798065,
-0.585431694984436,
-0.03129803016781807,
0.07223057001829147,
-0.7895735502243042,
-0.3701021671295166,
0.2908093333244324,
-0.7992483377456665,
0.5210459232330322,
-0.2804492115974426,
-0.09526348114013672,
0.03682084381580353,
-0.09348920732736588,
0.20867568254470825,
-0.12167833000421524,
0.10384923964738846,
0.14298588037490845,
-0.28640982508659363,
0.2812356650829315,
-0.06155245751142502,
-0.11499635875225067,
-0.13181360065937042,
0.003088802332058549,
-0.5595767498016357,
0.5812799334526062,
-5.714665412902832,
0.041118115186691284,
-0.14652788639068604,
-0.5807923078536987,
-0.12211322784423828,
-0.12437572330236435,
0.16776703298091888,
0.11216895282268524,
0.0036996458657085896,
0.10412457585334778,
0.4037013351917267,
0.4549284279346466,
0.018945321440696716,
0.020052490755915642,
0.011159121990203857,
0.15664416551589966,
-0.38501763343811035,
-0.2619672417640686,
-0.07113637775182724,
0.03009934350848198,
0.9862356185913086,
-0.1397296041250229,
-0.03474026173353195,
0.8134932518005371,
0.09922579675912857,
0.9237463474273682,
-0.4009057283401489,
0.3443423807621002,
-0.7162505388259888,
-0.6910768747329712,
0.34066241979599,
-0.23348340392112732,
-0.09610150754451752,
-0.2702057361602783,
0.37197819352149963,
0.06650432199239731,
-0.07987440377473831,
0.3550545275211334,
-0.1202925592660904,
-0.20492826402187347,
0.4169536232948303,
-0.2614196836948395,
-0.43386363983154297,
0.10781238973140717,
0.7923651933670044,
-0.17404745519161224,
-0.1837855577468872,
0.28820767998695374,
-0.6490216255187988,
0.45485159754753113,
0.3020099401473999,
-0.08328431844711304,
-0.23780131340026855,
0.764180600643158,
0.625816285610199,
0.12376327067613602,
-0.09911424666643143,
0.2635776698589325,
-0.19638243317604065,
0.0921529158949852,
-0.3017505705356598,
0.2715355455875397,
-0.40252143144607544,
-0.31628337502479553,
-0.5115464925765991,
0.09213171899318695,
-0.4277217984199524,
-0.026211341843008995,
0.6350840330123901,
0.04940171539783478,
-0.009464873932301998,
0.4088945686817169,
0.6754980683326721,
-0.519392728805542,
0.38165244460105896,
0.033210523426532745,
0.23002243041992188,
0.1850724220275879,
0.34042641520500183,
-0.2076857089996338,
-0.5328856706619263,
-0.05531134828925133,
0.04101480543613434,
-0.6655428409576416,
-0.15458092093467712,
-0.9815623760223389,
-0.7398327589035034,
0.5507513880729675,
0.16334307193756104,
0.3780525326728821,
0.6402321457862854,
-0.2199683040380478,
0.4900212585926056,
0.23604761064052582,
0.6607100367546082,
0.23026823997497559,
0.3050314486026764,
0.6501096487045288,
0.8263810873031616,
-0.11072719097137451,
0.9993454217910767,
-0.16723939776420593,
-0.3489026129245758,
-0.8839625120162964,
0.003967731259763241,
0.004103709943592548,
-0.47815579175949097,
0.28779247403144836,
0.660622775554657,
-0.6141923666000366,
0.46769943833351135,
0.14321379363536835,
0.2536492347717285,
-0.6234786510467529,
0.5268386006355286,
-0.7299965620040894,
-0.11406886577606201,
0.5177392363548279,
0.46850287914276123,
-0.4733409285545349,
-0.20623649656772614,
0.48445168137550354,
-0.3514043092727661,
0.29752352833747864,
-0.09189893305301666,
0.5313178896903992,
0.16733692586421967,
1.112451195716858,
-0.8586797714233398,
-0.26692742109298706,
0.2983912229537964,
0.46976613998413086,
0.1369648426771164,
-0.1531112939119339,
-0.22346757352352142,
-0.4151994585990906,
-0.45481032133102417,
0.35178786516189575,
0.07293742150068283,
-0.4842761754989624,
0.6271300315856934,
0.11389686912298203,
0.05836871638894081,
-0.35033583641052246,
-0.2473662793636322,
-0.04891394078731537,
-0.12721607089042664,
0.3352908194065094,
0.25359007716178894,
-0.14354440569877625,
0.40682554244995117,
0.2217690497636795,
0.06754934042692184,
-0.0995507463812828,
-0.40077853202819824,
0.4523131549358368,
0.5106530785560608,
0.27130427956581116,
-0.10843448340892792,
-0.4967603087425232,
0.1357540339231491,
-0.1801494061946869,
-1.0830777883529663,
-0.25897476077079773,
-0.39974653720855713,
0.11996672302484512,
0.1276911199092865,
-0.4671676456928253,
0.2536783814430237,
0.5344230532646179,
0.09316849708557129,
-0.3991239070892334,
-0.5066300630569458,
-0.030928079038858414,
0.3840770721435547,
-0.22940252721309662,
-0.6575450897216797,
-0.21988137066364288,
0.2503884732723236,
0.7988467216491699,
-0.0505438968539238,
-0.9831623435020447,
0.0018976033898070455,
0.4782336354255676,
0.7230547070503235,
0.4005036950111389,
0.14866288006305695,
-0.07561314105987549,
0.0007382254698313773,
-0.5144572257995605,
0.13806946575641632,
-0.3291948437690735,
0.2858477234840393,
-0.2841321527957916,
0.13817085325717926,
-0.1659729778766632,
-0.10274015367031097,
0.539412796497345,
0.12792199850082397,
-0.5271949172019958,
-0.3207530975341797,
0.8327455520629883,
-0.5005303025245667,
0.14521463215351105,
1.0572718381881714,
-0.6176943182945251,
0.22581051290035248,
-0.41206154227256775,
-0.07061229646205902,
-0.005825098603963852,
-0.5630979537963867,
-0.06653979420661926,
0.3356820344924927,
0.25351613759994507,
-0.4245743751525879,
0.2472509741783142,
-0.20729582011699677,
-0.45871177315711975,
-0.46469980478286743,
0.22923773527145386,
0.012122598476707935,
-0.0073757413774728775,
-0.18863391876220703,
0.1628069430589676,
-0.3638661503791809,
0.31878048181533813,
0.2700762450695038,
-0.6420924663543701,
0.4003188908100128,
-0.2090483009815216,
-0.0895768254995346,
0.03906816616654396,
-0.39217838644981384,
-0.044429756700992584,
0.09168949723243713,
-0.47699081897735596,
0.5305085778236389,
0.3927278220653534,
0.4587712585926056,
0.3242794871330261,
0.5348946452140808,
0.6326282620429993,
-0.5570806860923767,
0.4134677052497864,
0.3012062907218933,
0.4118958115577698,
0.2976337969303131,
-0.8168045878410339,
-0.6738423705101013,
0.12515316903591156,
0.28618332743644714,
-0.06807848066091537,
0.21937650442123413,
0.39831411838531494,
0.5094539523124695,
-0.34124138951301575,
-0.10672290623188019,
-0.5873808860778809,
-0.31257307529449463,
0.14713941514492035,
-0.18240807950496674,
0.05636240914463997,
0.34815388917922974,
0.060781288892030716,
0.34223586320877075,
0.06224026530981064,
-0.35949090123176575,
-0.12688422203063965,
0.516422688961029,
-0.23996460437774658,
0.766333281993866,
0.5048292875289917,
0.6678213477134705,
0.294831246137619,
-0.30668482184410095,
0.5152302384376526,
-0.3002608120441437,
-0.16941316425800323,
0.036700375378131866,
0.7769746780395508,
-0.22249014675617218,
-0.20785090327262878,
0.33503100275993347,
-0.7961448431015015,
0.41443923115730286,
-0.7301732301712036,
0.6589340567588806,
-0.03633053973317146,
-0.12018939107656479,
-0.4846210479736328,
-0.0779932290315628,
0.012324334122240543,
-0.24450193345546722,
-0.39385753870010376,
-0.24867495894432068,
-0.18591929972171783,
0.18232068419456482,
0.15029892325401306,
0.13073855638504028,
-0.22436019778251648,
-0.5343884229660034,
0.4447334110736847,
-0.03967442736029625,
-0.977354884147644,
0.5311492681503296,
0.06209957227110863,
0.20956434309482574,
-0.3560526967048645,
-0.5022921562194824,
-0.38648295402526855,
0.10466185212135315,
-0.204018235206604,
0.2181437909603119,
0.8064234852790833,
-0.2825552821159363,
0.10476072132587433,
-0.4797321557998657,
-0.09532350301742554,
0.732883095741272,
0.17548640072345734,
0.005186100956052542,
1.2205216884613037,
0.378074586391449,
-0.15454550087451935,
0.13220088183879852,
0.1181415542960167,
0.06332974880933762,
0.20818299055099487,
0.4097970426082611,
0.6516161561012268,
0.35915765166282654,
0.07165492326021194,
-0.22553829848766327,
1.067280888557434,
0.327360600233078,
-0.09608778357505798,
0.45695897936820984,
-0.4414636194705963,
-0.6511262059211731,
-0.07990795373916626,
0.7170811295509338,
-0.2952640652656555,
-0.21242479979991913,
0.352742999792099,
-0.3065289258956909,
0.591965913772583,
0.11975402384996414,
0.2180866003036499,
-0.24604612588882446,
-0.07743970304727554,
0.3875181972980499,
-0.35560908913612366,
-0.3528848886489868,
-0.0814615860581398,
-0.3459908664226532,
-0.010170535184442997,
0.33939194679260254,
-0.5666971206665039,
-0.7441384792327881,
0.09005410224199295,
-0.5702893137931824,
0.11836310476064682,
-0.34770190715789795,
0.6677087545394897,
0.1615256518125534,
0.055440597236156464,
0.2288035750389099,
-0.007995332591235638,
0.250014066696167,
0.06259093433618546,
-0.5997270941734314,
0.07344170659780502,
-0.3120918571949005,
0.10177605599164963,
-0.10953124612569809,
-0.7516019940376282,
-0.05660845711827278,
0.49159517884254456,
0.19217847287654877,
-0.2727247476577759,
-0.5704361796379089,
-0.036261800676584244,
-0.09943342208862305,
-0.6423272490501404,
0.10048042237758636,
-0.6351380944252014,
-0.13201919198036194,
0.015483404509723186,
0.15228331089019775,
0.2865685224533081,
0.36999252438545227,
-0.433031290769577,
-0.3228543996810913,
0.12704496085643768,
0.5241957306861877,
-0.6507624387741089,
0.2334572672843933,
0.2490541934967041,
-0.46759817004203796,
0.6369994282722473,
0.17677421867847443,
-0.1299806535243988,
0.07323558628559113,
0.47669580578804016,
-1.2320091724395752,
0.06738851219415665,
-0.12499307096004486,
-0.31919002532958984,
-0.5959575176239014,
-0.080413319170475,
0.2933470606803894,
0.24815420806407928,
-0.463514119386673,
0.33456161618232727,
0.24580712616443634,
0.5222591757774353,
0.14802809059619904,
-0.3701905906200409,
-0.3035978674888611,
-0.36359453201293945,
-0.05076945945620537,
-0.35592180490493774,
0.7681242823600769,
0.23643583059310913,
0.26948270201683044,
-0.03520932421088219,
0.7589698433876038,
0.012058058753609657,
-0.2376205325126648,
0.5329279899597168,
-0.6158430576324463,
0.6836695671081543,
-0.5197134017944336,
0.008535906672477722,
-0.4712989628314972,
-0.4485962390899658,
0.5093171000480652,
-0.34061455726623535,
-0.496709406375885,
-0.07744017988443375,
-0.1648230254650116,
-0.5052977204322815,
0.16233956813812256,
0.04097060486674309,
0.24255074560642242,
-0.038224879652261734,
0.5135449171066284,
-0.4676876366138458,
-0.281436026096344,
0.22907654941082,
-0.00048453014460392296,
-0.35054847598075867,
0.10660263895988464,
0.2302023321390152,
0.2699235677719116,
0.41418248414993286,
-0.2969881594181061,
-0.3464283347129822,
-0.24115221202373505,
0.2553808093070984
] |
Over the last decades, mesenchymal stromal cells (MSC) have been the focus of intense research by academia and industry due to their unique features. MSC can be easily isolated and expanded through in vitro culture by taking full advantage of their self-renewing capacity. In addition, MSC exert immunomodulatory effects and can be differentiated into various lineages, which makes them highly attractive for clinical applications in cell-based therapies. In this review, we attempt to provide a brief historical overview of MSC discovery, characterization, and the first clinical studies conducted. The current MSC manufacturing platforms are reviewed with special attention regarding the use of bioreactors for the production of GMP-compliant clinically relevant cell numbers. The first commercial MSC-based products are also addressed, as well as the remaining challenges to the widespread use of MSC-derived products. | [
0.013156600296497345,
0.002907165791839361,
-0.007840072736144066,
0.01918044500052929,
-0.007319054566323757,
0.002674170769751072,
0.009771971963346004,
-0.029135458171367645,
-0.014936346560716629,
-0.008035891689360142,
-0.004801299888640642,
0.020323000848293304,
-0.0020277081057429314,
0.007008851505815983,
-0.002161187818273902,
-0.016736306250095367,
-0.014217207208275795,
0.021577101200819016,
0.009631166234612465,
-0.005069834180176258,
0.005415548104792833,
0.0035872540902346373,
0.01045147329568863,
0.0005926929879933596,
0.02320932038128376,
0.009303641505539417,
-0.005151789635419846,
-0.031195467337965965,
-0.001985708484426141,
-0.008436097763478756,
-0.018546082079410553,
-0.008116009645164013,
0.0035764635540544987,
-0.026496458798646927,
0.0023895897902548313,
0.00451866677030921,
-0.0026719835586845875,
0.03221171349287033,
0.01277855783700943,
-0.0027185948565602303,
0.029112081974744797,
-0.007896818220615387,
0.00902607012540102,
-0.0003982123453170061,
-0.006332261022180319,
-0.005285938270390034,
0.0006153928115963936,
0.0030325250700116158,
-0.002995463088154793,
0.01091722585260868,
-0.011802179738879204,
-0.013380365446209908,
-0.0030000514816492796,
0.0019972992595285177,
-0.006446122191846371,
0.00364780705422163,
0.019659092649817467,
0.005030142143368721,
0.013356619514524937,
-0.009767867624759674,
0.010757907293736935,
-0.016124079003930092,
0.01879388652741909,
-0.01695166900753975,
-0.018759168684482574,
-0.06687217950820923,
0.020091135054826736,
0.030794672667980194,
0.0062829479575157166,
0.003147741314023733,
-0.004253983031958342,
0.012410740368068218,
0.011852586641907692,
-0.0026586714666336775,
0.01085625495761633,
-0.010639918968081474,
-0.01781843788921833,
0.014270637184381485,
-0.01483728177845478,
0.001400304026901722,
0.007932685315608978,
-0.008452601730823517,
0.015357730910182,
0.0037392745725810528,
0.006127787288278341,
-0.0029574097134172916,
-0.036371685564517975,
0.004829913377761841,
0.008290505968034267,
0.005311977583914995,
0.0005242009647190571,
0.017626386135816574,
-0.01377975195646286,
0.014167135581374168,
-0.017354287207126617,
0.0017799409106373787,
-0.0219863448292017,
-0.0016196686774492264,
-0.00041986070573329926,
0.0005963509902358055,
-0.019078468903899193,
0.0030100042931735516,
0.01823035627603531,
0.0259605310857296,
-0.004144242033362389,
0.007613836321979761,
0.008045557886362076,
0.0009080064482986927,
-0.0006622890941798687,
0.008642524480819702,
-0.0016115554608404636,
-0.021926911547780037,
-0.021864088252186775,
0.02795518934726715,
-0.013627054169774055,
0.0036123855970799923,
-0.030501697212457657,
0.020270537585020065,
0.014760445803403854,
0.0020385843235999346,
-0.01314264815300703,
0.0037272474728524685,
0.008267314173281193,
-0.016005966812372208,
0.007920758798718452,
0.009731899946928024,
-0.06037408113479614,
0.007380688562989235,
-0.016948800534009933,
0.0023554502986371517,
-0.006237081717699766,
0.011034652590751648,
0.05160883069038391,
-0.005954579450190067,
0.005325894337147474,
-0.010332145728170872,
-0.027294855564832687,
-0.01499776542186737,
0.013059167191386223,
-0.02437220886349678,
-0.016762297600507736,
0.011006154119968414,
-0.001992156496271491,
0.004244932904839516,
0.013204300776124,
-0.01192091777920723,
-0.007616910617798567,
0.002892792224884033,
-0.0038552372716367245,
0.013444362208247185,
0.01228160411119461,
-0.01417318731546402,
0.0034493496641516685,
-0.010087819769978523,
-0.006565399002283812,
0.02559550292789936,
-0.003082635346800089,
-0.007008622400462627,
-0.005977371707558632,
0.0019332547672092915,
-0.03491419181227684,
-0.02176319994032383,
0.028519822284579277,
0.008632760494947433,
0.01783749833703041,
0.00207719998434186,
0.004816234111785889,
-0.008161250501871109,
-0.0022543042432516813,
0.004183607641607523,
-0.00969347357749939,
0.022477339953184128,
-0.0013450258411467075,
0.012044131755828857,
0.011813992634415627,
0.011981679126620293,
-0.005356191657483578,
0.007613355293869972,
-0.012179907411336899,
0.06702575832605362,
0.01535023469477892,
0.020971672609448433,
0.019405897706747055,
-0.010476170107722282,
0.0017997855320572853,
-0.02152262255549431,
0.0035641430877149105,
-0.00958468858152628,
-0.020314879715442657,
0.008696313947439194,
0.01238199695944786,
-0.014793877489864826,
-0.018938610330224037,
0.008494033478200436,
0.003991585690528154,
0.0028672069311141968,
0.02863236330449581,
-0.00701963622123003,
0.008705849759280682,
-0.0429907850921154,
0.017830228433012962,
0.006909356452524662,
0.048978742212057114,
0.0003111218102276325,
0.006601028144359589,
0.014983030036091805,
0.029643112793564796,
-0.015665315091609955,
-0.005578815005719662,
0.013024027459323406,
0.017426924780011177,
0.006002839654684067,
0.006811985746026039,
-0.024397071450948715,
0.009653224609792233,
0.01634119264781475,
-0.0038731638342142105,
0.010502596385776997,
-0.014512797817587852,
-0.016933990642428398,
-0.005071346648037434,
0.014743709936738014,
0.003935182932764292,
0.005758916959166527,
0.023610113188624382,
-0.02443641424179077,
0.008425135165452957,
0.012448047287762165,
-0.0064646522514522076,
-0.004117227625101805,
-0.022984573617577553,
-0.019547075033187866,
-0.010889741592109203,
-0.006914180237799883,
-0.009567221626639366,
0.007093990221619606,
0.012398234568536282,
0.014612529426813126,
0.018270596861839294,
-0.015477621927857399,
0.002997735980898142,
-0.002100130310282111,
0.02176446095108986,
0.004254558589309454,
-0.00722765177488327,
0.02105487510561943,
0.007659003138542175,
0.018438495695590973,
0.02419712394475937,
0.0018264353275299072,
0.004710828885436058,
0.018664201721549034,
0.0014126838650554419,
0.008901169523596764,
0.01027960330247879,
-0.004821065813302994,
-0.012236278504133224,
0.040257468819618225,
0.02509191446006298,
-0.02730463817715645,
0.00004857662133872509,
0.004828480072319508,
-0.04445866495370865,
0.015430932864546776,
0.008847888559103012,
-0.011810289695858955,
0.016849525272846222,
0.0190182626247406,
0.011962264776229858,
0.01882859691977501,
0.005727560259401798,
0.0015985232312232256,
0.005019943695515394,
-0.08167339861392975,
-0.014604575000703335,
0.02191724255681038,
0.0015642731450498104,
0.015749119222164154,
-0.03447187691926956,
-0.009199744090437889,
-0.002362215192988515,
-0.014112918637692928,
0.004417820833623409,
-0.005340096075087786,
0.008800621144473553,
-0.0036846743896603584,
-0.01258876733481884,
-0.013347379863262177,
-0.001597725204192102,
0.0111238993704319,
0.009945165365934372,
0.0020895914640277624,
-0.005683759227395058,
-0.0064737857319414616,
-0.025169573724269867,
-0.0015388969331979752,
0.014028564095497131,
0.015481382608413696,
-0.007489542011171579,
0.004731718450784683,
0.005701905116438866,
-0.030831851065158844,
0.007179819047451019,
-0.009571022354066372,
-0.001123374910093844,
0.02004343643784523,
0.012620815075933933,
-0.008186686784029007,
0.005767317488789558,
0.009927771985530853,
-0.01727217622101307,
-0.019842805340886116,
0.025700189173221588,
0.01208472065627575,
0.012782132253050804,
0.02534499391913414,
-0.004535730928182602,
0.013129917904734612,
0.004870699718594551,
0.026499807834625244,
0.033402711153030396,
0.010121558792889118,
-0.002545868046581745,
0.009269220754504204,
-0.0014162288280203938,
0.002863699570298195,
0.013654484413564205,
-0.018088646233081818,
-0.02972043678164482,
-0.04257477819919586,
0.020949693396687508,
-0.021305548027157784,
0.0008916981751099229,
0.0537082701921463,
-0.02233562245965004,
0.01029747724533081,
0.024708900600671768,
-0.01673014461994171,
0.008953938260674477,
0.0034203703980892897,
0.005753472447395325,
-0.00917837955057621,
0.0012686816044151783,
-0.023422453552484512,
-0.008168410509824753,
0.009248754009604454,
0.005439835134893656,
-0.004386294167488813,
-0.010025491937994957,
-0.017150960862636566,
0.004237670451402664,
0.019073486328125,
-0.02378840744495392,
0.0025067399255931377,
0.0024496708065271378,
-0.0004443889483809471,
-0.01886846125125885,
-0.022685401141643524,
-0.024801049381494522,
0.011262049898505211,
0.018282076343894005,
-0.0019745505414903164,
-0.016361571848392487,
0.004924597684293985,
-0.017498424276709557,
-0.0072876811027526855,
0.0017520070541650057,
-0.002789865480735898,
0.014175400137901306,
0.0022645099088549614,
-0.0031102197244763374,
0.012469703331589699,
0.009871994145214558,
-0.019095992669463158,
0.0020931409671902657,
-0.010639634914696217,
-0.012870009057223797,
-0.007000145502388477,
0.015594772063195705,
0.006501579191535711,
-0.006245436146855354,
0.008126668632030487,
-0.006922422908246517,
-0.0028047591913491488,
0.010374646633863449,
-0.008828269317746162,
0.04457469284534454,
0.008892838843166828,
0.017348583787679672,
-0.004947454668581486,
-0.058846354484558105,
0.07212114334106445,
0.002306129317730665,
-0.00879042036831379,
-0.027551928535103798,
0.0027294852770864964,
-0.04045683145523071,
-0.009033344686031342,
0.01645832136273384,
-0.02300587110221386,
0.003016169648617506,
0.013277431018650532,
0.006442981772124767,
-0.014485565945506096,
0.008329181000590324,
-0.0028548333793878555,
0.009217177517712116,
-0.01729610748589039,
-0.0007315957918763161,
-0.00939421821385622,
0.010915525257587433,
0.012653595767915249,
-0.026520198211073875,
-0.01177717000246048,
0.0300002284348011,
-0.0030269126873463392,
-0.014644949696958065,
0.016811294481158257,
-0.010730274952948093,
-0.00044698966667056084,
0.0061910729855299,
0.014197379350662231,
0.01770516112446785,
-0.004439653363078833,
-0.0033511300571262836,
0.02922084555029869,
0.012059847824275494,
0.00455001275986433,
0.011892469599843025,
-0.02134357951581478,
0.009384145960211754,
-0.008334744721651077,
-0.014498686417937279,
-0.009126948192715645,
0.01962178386747837,
-0.013258187100291252,
0.007806007284671068,
0.0162552148103714,
-0.0046156784519553185,
0.00857628881931305,
-0.018372410908341408,
-0.012381901033222675,
0.00808606669306755,
0.014815816655755043,
0.022556353360414505,
-0.008065576665103436,
0.007586101535707712,
0.006367937661707401,
-0.004751121625304222,
0.019731080159544945,
-0.024526333436369896,
0.0015523461624979973,
0.004152184352278709,
-0.0016312950756400824,
-0.0072455392219126225,
-0.004999183584004641,
-0.016140667721629143,
-0.02587825246155262,
0.002923190826550126,
0.001987953670322895,
0.010625462047755718,
-0.007036709226667881,
-0.019604744389653206,
-0.028821593150496483,
-0.016138652339577675,
-0.008816216140985489,
0.006482190452516079,
-0.003485525958240032,
-0.009546969085931778,
-0.01426607370376587,
0.020236048847436905,
-0.016143150627613068,
-0.01595010608434677,
0.001963847316801548,
0.0023911800235509872,
-0.01899018883705139,
-0.020978299900889397,
-0.04959525167942047,
-0.07460483908653259,
0.014886260032653809,
-0.021563371643424034,
-0.004655573982745409,
-0.0030755293555557728,
0.004035599064081907,
-0.019546587020158768,
0.02124674618244171,
0.024168314412236214,
0.00597735308110714,
0.023144418373703957,
0.014489660039544106,
-0.00698805321007967,
-0.004639867693185806,
0.010681860148906708,
-0.006169606931507587,
0.019902756437659264,
-0.001608351245522499,
-0.022326771169900894,
-0.010701704770326614,
0.013866670429706573,
-0.0045670694671571255,
-0.009197910316288471,
0.004017803817987442,
-0.0016906771343201399,
-0.08080476522445679,
0.0229929368942976,
-0.013535106554627419,
-0.02894013002514839,
0.00020615762332454324,
-0.003522370243445039,
0.001615108223631978,
-0.010165711864829063,
-0.028668537735939026,
-0.018621321767568588,
0.02329438365995884,
0.018819531425833702,
-0.013851268216967583,
-0.004081028513610363,
0.012374402023851871,
-0.011735223233699799,
0.003310953499749303,
-0.01440383680164814,
-0.010043153539299965,
-0.007913229987025261,
-0.007056587375700474,
0.002643883228302002,
-0.013195952400565147,
-0.030882496386766434,
-0.015818625688552856,
-0.006139440927654505,
0.016689226031303406,
0.012669013813138008,
0.0002620536834001541,
0.028990233317017555,
-0.015014112927019596,
-0.00012402585707604885,
-0.012473523616790771,
0.010670973919332027,
-0.0005742774810642004,
-0.016098489984869957,
-0.0191899836063385,
-0.0037817484699189663,
-0.028715286403894424,
-0.0009330743923783302,
-0.00919727236032486,
0.01940489187836647,
-0.002226695418357849,
-0.011364007368683815,
0.023960866034030914,
-0.009561332874000072,
0.0036791996099054813,
-0.00000497954897582531,
0.013307305052876472,
0.004079204984009266,
0.0004039574705529958,
-0.007136214524507523,
-0.002200691495090723,
0.020597387105226517,
0.003220165614038706,
0.02076597884297371,
0.001710798591375351,
0.01855377107858658,
0.00017261551693081856,
0.0036226415541023016,
0.009202801622450352,
-0.024418480694293976,
-0.01269170455634594,
0.07218506932258606,
0.0052741700783371925,
0.02745630592107773,
-0.031694620847702026,
0.003497860860079527,
0.00047454459127038717,
-0.02758919820189476,
-0.022147202864289284,
0.017521414905786514,
-0.01172666996717453,
0.012435298413038254,
-0.0028310436755418777,
0.005212786607444286,
0.01232050359249115,
0.014236844144761562,
-0.01576753705739975,
0.004494622349739075,
0.008290253579616547,
-0.0183654073625803,
0.02428722009062767,
-0.008107703179121017,
-0.004648360423743725,
-0.00978760700672865,
-0.005249996669590473,
-0.0033416771329939365,
-0.00968291237950325,
-0.04078761488199234,
0.02299758419394493,
-0.014882258139550686,
0.009619018994271755,
-0.005197436083108187,
0.009173678234219551,
0.0013768562348559499,
0.023153938353061676,
0.027775418013334274,
0.031024392694234848,
-0.01361459493637085,
-0.003988840617239475,
-0.0005634590052068233,
0.013282880187034607,
-0.02673385664820671,
0.01581725664436817,
0.0036140093579888344,
-0.00290983566083014,
0.0013009333051741123,
-0.005954607389867306,
-0.005818246863782406,
-0.057296041399240494,
-0.014757785946130753,
-0.013547091744840145,
0.02554333209991455,
0.007631383836269379,
0.0053695631213486195,
-0.0019095154711976647,
0.01905263587832451,
-0.0021325903944671154,
-0.017862049862742424,
0.01864311285316944,
-0.004775132983922958,
-0.061828650534152985,
0.028766704723238945,
-0.0017923738341778517,
-0.024214763194322586,
-0.013978147879242897,
0.00373472785577178,
0.0070720030926167965,
0.018609143793582916,
-0.0041701579466462135,
-0.00540369376540184,
0.014735878445208073,
-0.019362132996320724,
-0.015796098858118057,
0.004275104030966759,
0.002001502551138401,
0.020685799419879913,
0.00048682873602956533,
0.01032375730574131,
-0.017413172870874405,
0.013912332244217396,
0.0020055097993463278,
-0.013913460075855255,
0.03014317899942398,
-0.012545175850391388,
0.030132554471492767,
0.018921002745628357,
0.013038380071520805,
0.020057592540979385,
0.001769144320860505,
-0.00761382794007659,
0.009718872606754303,
0.0352676585316658,
0.0053492579609155655,
-0.006179085001349449,
0.030788665637373924,
0.007608708925545216,
0.03450508415699005,
0.028195613995194435,
0.012872515246272087,
0.0048020039685070515,
0.005360713228583336,
0.007698278874158859,
0.004783716518431902,
-0.020065657794475555,
-0.023444416001439095,
-0.0194484144449234,
-0.012215755879878998,
0.03553131967782974,
0.049938417971134186,
-0.001413579797372222,
-0.014611097052693367,
-0.010974202305078506,
-0.01225128024816513,
-0.008498712442815304,
0.0011261564213782549,
-0.028818972408771515,
-0.0062169479206204414,
-0.02303135022521019,
-0.0015985225327312946,
-0.0037278495728969574,
-0.01341027207672596,
-0.01628212258219719,
-0.003094607498496771,
-0.03101777285337448,
0.010117758996784687,
-0.003968230448663235,
-0.004791606683284044,
-0.016441183164715767,
0.030464865267276764,
-0.01358918659389019,
0.01284666359424591,
0.00526135228574276,
-0.0016833257395774126,
0.01583137735724449,
0.023727532476186752,
0.0002371007576584816,
-0.025650417432188988,
-0.01779213547706604,
0.002848522737622261,
-0.004826484248042107,
0.00046076811850070953,
0.0417318120598793,
-0.016991175711154938,
0.003486739005893469,
-0.01226038858294487,
0.009138280525803566,
-0.02019726112484932,
-0.0013926122337579727,
0.023342765867710114,
0.010313143953680992,
0.014943359419703484,
-0.003767412854358554,
0.008392348885536194,
0.00040327105671167374,
-0.0020245355553925037,
-0.03017084300518036,
0.03544017672538757,
0.003226240398362279,
-0.0126759372651577,
-0.015905020758509636,
0.006322011351585388,
-0.009776260703802109,
0.0033010777551680803,
0.011510686948895454,
0.004932179115712643,
-0.003998253960162401,
0.01968095451593399,
0.007643773220479488,
0.004500237293541431,
-0.007351086474955082,
-0.005402003414928913,
0.02392343431711197,
0.005254288204014301,
-0.010975047945976257,
0.017148736864328384,
-0.010150711983442307,
-0.007482277695089579,
-0.006942726206034422,
-0.003959984984248877,
0.00116737128701061,
0.007833082228899002,
-0.0022363055031746626,
-0.036999400705099106,
0.02351130172610283,
-0.004498278722167015,
-0.0021597356535494328,
-0.008133361116051674,
-0.018871068954467773,
-0.02317245677113533,
0.018138747662305832,
-0.015634261071681976,
-0.006407714448869228,
-0.010150616988539696,
-0.014380245469510555,
-0.008415497839450836,
-0.00034143077209591866,
-0.02005917578935623,
0.007878590375185013,
0.0036776550114154816,
0.022774308919906616,
-0.005526131484657526,
0.0012663807719945908,
-0.008144508115947247
] | [
0.13809369504451752,
-0.09063906222581863,
0.41864851117134094,
0.11097966879606247,
0.43640971183776855,
0.27924346923828125,
-0.20250555872917175,
0.18553251028060913,
-0.5214410424232483,
-0.3299718499183655,
-0.25179171562194824,
0.15750078856945038,
0.00736093707382679,
0.7641595005989075,
0.042453255504369736,
0.512521505355835,
0.5354281663894653,
0.28483134508132935,
0.1919681280851364,
0.05684598535299301,
-0.42022645473480225,
-0.4549556374549866,
0.6107750535011292,
0.07618764042854309,
-0.08343172818422318,
-0.2994322180747986,
0.22190184891223907,
0.05052902549505234,
0.21386733651161194,
-0.2554330825805664,
-0.27382543683052063,
-0.041070833802223206,
-0.2893748879432678,
-0.16517561674118042,
0.30909013748168945,
-0.383932888507843,
-0.6221776604652405,
0.0724758505821228,
-0.3711870610713959,
-0.7518848776817322,
-0.5919747948646545,
0.023336797952651978,
0.3303911089897156,
0.4350181818008423,
-0.6445090770721436,
0.08567201346158981,
-1.048781394958496,
0.4607500433921814,
-0.32412421703338623,
0.3228239417076111,
-0.28600481152534485,
-0.08521971106529236,
0.2308672070503235,
-0.20289376378059387,
0.22823090851306915,
0.3359522223472595,
-0.4808535575866699,
-0.11506707221269608,
0.2619856894016266,
-0.5895602703094482,
-0.14019575715065002,
-0.14122818410396576,
-0.271716445684433,
-0.015628701075911522,
0.07140236347913742,
0.3021795451641083,
0.24335205554962158,
-0.7754759788513184,
-0.8131646513938904,
-0.22394506633281708,
0.4123716950416565,
-0.5234686732292175,
0.34501633048057556,
0.44937577843666077,
-0.04218767210841179,
-0.12968698143959045,
-0.07788506895303726,
-0.10310586541891098,
0.4140525758266449,
-0.012965024448931217,
-0.032594241201877594,
0.04759946092963219,
0.18095926940441132,
0.195950448513031,
0.4963702857494354,
0.6325551867485046,
-0.2912675738334656,
0.7354146838188171,
-0.45767974853515625,
0.0591852180659771,
-0.09885714948177338,
-0.017561545595526695,
0.6694004535675049,
0.5069766044616699,
0.43448227643966675,
-0.1821158528327942,
0.0409807451069355,
-0.165401890873909,
-0.004012365825474262,
0.4767901599407196,
-0.42949503660202026,
0.16794507205486298,
-0.30249133706092834,
-0.2748207449913025,
-0.4603366255760193,
-0.012362252920866013,
-0.6598054766654968,
-0.08938125520944595,
-0.4488277733325958,
0.31008654832839966,
-0.22295574843883514,
-0.2689209580421448,
-0.24267807602882385,
0.00404798798263073,
-0.28696906566619873,
0.2985406517982483,
0.3211631774902344,
-0.3009573221206665,
-0.3266197741031647,
0.4874081313610077,
-0.016373690217733383,
0.9219650030136108,
-0.3396192789077759,
-0.14775656163692474,
-0.11105922609567642,
-0.14392831921577454,
0.41694051027297974,
0.42132630944252014,
-0.34492388367652893,
0.16265274584293365,
0.043545737862586975,
0.8054907321929932,
-0.17273171246051788,
0.21822260320186615,
0.4873787760734558,
-0.39659595489501953,
0.2019987851381302,
-0.1430947482585907,
0.3553924262523651,
0.2877761125564575,
-0.7192966938018799,
-0.5188361406326294,
-0.2565411627292633,
-0.047075264155864716,
-0.04334799572825432,
-0.6197690367698669,
-0.2324247658252716,
-0.2548745572566986,
-0.45767149329185486,
-0.3240317702293396,
-0.45714253187179565,
-0.19316111505031586,
-0.602327823638916,
-0.14637725055217743,
-0.03966411203145981,
0.8862029910087585,
-0.27023619413375854,
0.000017472837498644367,
0.08400334417819977,
-0.026673365384340286,
-0.25139734148979187,
0.17949840426445007,
-0.41715747117996216,
0.016405247151851654,
0.05958649516105652,
-0.20469489693641663,
0.7131409645080566,
0.47975537180900574,
-0.09284595400094986,
0.3118799030780792,
0.12060073018074036,
-0.23812706768512726,
0.14353342354297638,
-0.18875667452812195,
-0.40232110023498535,
0.05592988431453705,
0.21633021533489227,
0.053103622049093246,
0.231215238571167,
0.3354490101337433,
-0.6164956092834473,
0.2945868968963623,
0.020696211606264114,
-0.3406033515930176,
0.044420864433050156,
0.2523903548717499,
0.7229036688804626,
0.14395900070667267,
-0.4501424729824066,
-0.062017787247896194,
-0.23032405972480774,
-0.006059191655367613,
0.6408769488334656,
-0.7697854042053223,
1.0322692394256592,
0.27115514874458313,
-0.16291025280952454,
1.1089917421340942,
-0.6842296719551086,
0.2930050492286682,
0.07254211604595184,
0.5082749724388123,
0.0777726024389267,
-0.6464120745658875,
-0.4783371686935425,
-0.5063914656639099,
0.33954739570617676,
-0.28133630752563477,
0.2372450828552246,
-0.2549329698085785,
0.5456505417823792,
-0.6674502491950989,
0.4121774435043335,
-0.4982795715332031,
0.3211980164051056,
-0.3338497579097748,
-0.09727802127599716,
0.21995145082473755,
-0.3490869700908661,
-0.1531180739402771,
1.4056950807571411,
-0.38167285919189453,
0.3512920141220093,
0.8379731774330139,
-0.1027408093214035,
0.7105779647827148,
0.4099777340888977,
-0.44130197167396545,
0.9390230178833008,
0.3002766966819763,
0.37415871024131775,
-0.572007417678833,
-0.050564736127853394,
-0.557887613773346,
-0.2949425280094147,
0.26346495747566223,
0.37419068813323975,
-0.11421103030443192,
0.3198716640472412,
0.0910741537809372,
0.15498711168766022,
0.1153557300567627,
-0.6135078072547913,
0.04375424236059189,
0.3958216607570648,
-0.34858083724975586,
-0.2096315175294876,
0.10954111069440842,
-0.7013351917266846,
-0.5428673028945923,
-0.09119092673063278,
0.3257942795753479,
0.043002720922231674,
-0.2053212821483612,
0.49013930559158325,
-0.07715029269456863,
-0.331957072019577,
0.0721338763833046,
-0.031866367906332016,
0.16103534400463104,
-0.22729749977588654,
0.04368295148015022,
0.06943070888519287,
0.19504687190055847,
-0.27049490809440613,
-0.08546160161495209,
-0.07763238996267319,
-0.8024114966392517,
0.9405936598777771,
0.520636796951294,
0.639563798904419,
-0.153826043009758,
-0.3057233393192291,
-0.05845300108194351,
0.04633210971951485,
-0.5162326693534851,
-0.07845623046159744,
0.020207911729812622,
-0.2386908233165741,
-0.5626114010810852,
-0.004951333627104759,
0.4130244553089142,
0.4455549418926239,
-0.15869487822055817,
-0.22109036147594452,
-0.3612155020236969,
-0.3948018252849579,
-0.2916352152824402,
-0.46112170815467834,
0.05678956210613251,
-0.30945858359336853,
-0.06662717461585999,
-0.6266986131668091,
-0.27549049258232117,
-0.026345519348978996,
0.2868730425834656,
-0.039122357964515686,
0.1696545034646988,
0.3632679283618927,
0.1030389815568924,
-0.4072573184967041,
0.5666744112968445,
-0.36581185460090637,
-0.264188289642334,
-0.1744832843542099,
-0.26460084319114685,
-0.060282088816165924,
0.3653891384601593,
-5.849017143249512,
-0.20603784918785095,
-0.02160470187664032,
0.3429076075553894,
0.3615700602531433,
-0.20460043847560883,
0.6644024848937988,
-0.0949619710445404,
0.2097792774438858,
-0.23951123654842377,
-0.03970467671751976,
0.6380623579025269,
-0.11371391266584396,
0.5172291994094849,
-0.26249024271965027,
0.4601390063762665,
-0.05668375641107559,
-0.0252938661724329,
0.3642132878303528,
-0.13729284703731537,
0.1570420265197754,
-0.5676970481872559,
0.16397103667259216,
0.38104310631752014,
-0.16869817674160004,
0.3249567151069641,
-1.5921857357025146,
0.07726217061281204,
-0.33562999963760376,
0.09338237345218658,
-0.6487007141113281,
-0.5109034776687622,
-0.002768030157312751,
-0.9635361433029175,
0.3910733461380005,
0.1452714055776596,
0.10626550763845444,
-0.028318550437688828,
0.3909553587436676,
-0.8475935459136963,
0.7320318222045898,
0.21872976422309875,
-0.22456178069114685,
0.19519776105880737,
0.3815453052520752,
-0.4193045496940613,
-0.10022925585508347,
0.37711191177368164,
-0.29849526286125183,
0.8971943259239197,
0.09067855030298233,
-0.038380879908800125,
0.9353004693984985,
0.1078438013792038,
0.12867103517055511,
-0.08042928576469421,
0.23579831421375275,
0.42301324009895325,
-0.3048274517059326,
0.2134236991405487,
-0.5206299424171448,
-0.21784748136997223,
0.058647677302360535,
-0.6132403016090393,
-0.3998021185398102,
0.30054137110710144,
-0.7128276228904724,
-0.052933741360902786,
0.21703022718429565,
0.005819578189402819,
-0.34192830324172974,
0.8160445690155029,
-0.16091200709342957,
-0.6302397847175598,
0.7523782849311829,
-0.46521100401878357,
0.166972354054451,
-0.2735688388347626,
0.02423640340566635,
0.6343117356300354,
-0.19065165519714355,
-0.20361796021461487,
-0.3125433325767517,
0.09256275743246078,
-0.2931787669658661,
-0.8815067410469055,
-0.06736577302217484,
-0.058245521038770676,
-0.09436942636966705,
0.4086771309375763,
0.3798305094242096,
0.04761400446295738,
0.2466568797826767,
0.33598068356513977,
0.7302892208099365,
-0.3379519581794739,
0.3970605731010437,
0.44680461287498474,
0.3531549572944641,
-0.39460527896881104,
0.42636072635650635,
0.05842238664627075,
-0.3638099133968353,
-0.8741579055786133,
-0.2505646347999573,
0.03316611796617508,
-0.9793718457221985,
-0.1245732381939888,
0.4931108057498932,
-0.2026028037071228,
-0.031864751130342484,
0.02804512344300747,
-0.4706065356731415,
-0.36481887102127075,
0.6424558758735657,
-0.16842669248580933,
-0.19291573762893677,
0.5688610076904297,
0.7176817655563354,
-0.38726598024368286,
0.29924556612968445,
0.34856876730918884,
0.160379558801651,
0.27760446071624756,
0.0804533064365387,
-0.06971929222345352,
0.7153850197792053,
0.801789402961731,
-0.6220040917396545,
-0.3843168318271637,
0.16520854830741882,
0.48091816902160645,
-0.6298385858535767,
-0.1874736100435257,
0.23303639888763428,
0.5195549726486206,
-0.425717830657959,
-0.37299033999443054,
-0.06068764626979828,
-0.3517608940601349,
0.6923076510429382,
0.07440344244241714,
0.5340925455093384,
0.12970224022865295,
0.17846840620040894,
0.44323524832725525,
-0.16326124966144562,
0.47756844758987427,
0.16135485470294952,
0.16716423630714417,
0.11522705107927322,
-0.36627665162086487,
-0.03695734590291977,
-0.0992804542183876,
-0.07494472712278366,
-0.004360851366072893,
0.308673620223999,
0.1945985108613968,
0.35618269443511963,
-0.2272440642118454,
0.31298625469207764,
0.6080792546272278,
-1.1302683353424072,
0.0455019511282444,
-0.3221639394760132,
-0.1526689976453781,
-0.4075350761413574,
0.3295202851295471,
-0.011169307865202427,
0.37920355796813965,
-0.21091079711914062,
-0.22737722098827362,
-0.6435868144035339,
-0.6210029125213623,
0.12099442631006241,
-0.041151270270347595,
-0.009329302236437798,
0.1947661191225052,
0.03305349871516228,
0.001917626359499991,
0.2576436996459961,
-0.6944829225540161,
0.061449598520994186,
0.10486318916082382,
1.0066694021224976,
0.018739810213446617,
-0.169078066945076,
-0.19119243323802948,
-0.2142236977815628,
0.06069837138056755,
0.2356938272714615,
0.46012255549430847,
0.12208963930606842,
0.30668818950653076,
-0.3401038944721222,
0.008761405013501644,
-0.16610103845596313,
0.3532574474811554,
-0.023927675560116768,
-0.5809311866760254,
0.11606001853942871,
0.21984826028347015,
-0.4910646975040436,
0.29167041182518005,
0.5453057885169983,
0.06924977153539658,
0.017955061048269272,
-0.13434910774230957,
0.3669169247150421,
-0.22578388452529907,
-0.10369618982076645,
-0.42142054438591003,
0.7859631776809692,
0.5524393916130066,
-0.7460503578186035,
0.29371893405914307,
-0.27138933539390564,
-0.15157027542591095,
-0.2936135530471802,
0.5199671983718872,
-0.04246877506375313,
-0.30655384063720703,
-0.19533966481685638,
-0.27887532114982605,
-0.5520617961883545,
0.2421867549419403,
0.027034610509872437,
-0.3661322593688965,
-0.2227562665939331,
-0.12208105623722076,
-0.38574501872062683,
-0.2788280248641968,
0.06796222180128098,
-0.23130249977111816,
0.08946733176708221,
-0.11982928961515427,
-0.015077745541930199,
0.2871803939342499,
-0.36199694871902466,
0.44937559962272644,
0.2567126750946045,
0.21582676470279694,
-0.794493556022644,
-0.27719348669052124,
-0.3541026711463928,
0.667878270149231,
0.4450787901878357,
-0.3529360294342041,
-0.4762071371078491,
-0.16235461831092834,
0.34780576825141907,
-0.4145871102809906,
0.25965383648872375,
0.042483989149332047,
0.811576247215271,
0.41577935218811035,
0.32677650451660156,
-0.05456206575036049,
-0.18439021706581116,
-0.3612525761127472,
-0.27446338534355164,
-0.030986513942480087,
-0.28055474162101746,
-0.3041619062423706,
0.32526248693466187,
-0.09173886477947235,
-0.16485019028186798,
-0.5750470161437988,
0.44642403721809387,
0.1180577278137207,
0.1365327686071396,
0.0438370555639267,
0.831583559513092,
0.677460789680481,
0.015735454857349396,
0.5451796650886536,
-0.2642578184604645,
-0.0992322713136673,
0.09665791690349579,
0.09579942375421524,
-0.5221850275993347,
-0.2792445719242096,
0.06011604517698288,
-0.0531519390642643,
0.5515208840370178,
-0.003603167599067092,
0.31773433089256287,
-0.4192792475223541,
0.04585810750722885,
0.10274661332368851,
0.008955228142440319,
-0.20814776420593262,
-0.4902901351451874,
-0.2396397888660431,
-0.08719374239444733,
0.09963198006153107,
0.2674761712551117,
0.21346087753772736,
-0.15752144157886505,
0.1078893169760704,
-0.5966978073120117,
0.8119223713874817,
0.8725000023841858,
-0.8838034868240356,
0.48978108167648315,
0.5088814496994019,
0.3677063286304474,
0.01981823332607746,
-0.32378754019737244,
-0.287765771150589,
-0.03404461219906807,
-0.07541562616825104,
-0.014920546673238277,
0.012182154692709446,
-0.3816603124141693,
-0.26664283871650696,
0.01769649051129818,
-0.46523597836494446,
0.32966378331184387,
0.47149500250816345,
0.440260112285614,
0.6454931497573853,
-0.030648786574602127,
-0.5487644672393799,
-0.531826376914978,
0.619609534740448,
-0.11790335923433304,
-0.4049348533153534,
-0.14929074048995972,
0.12271973490715027,
0.5175756216049194,
0.560522735118866,
-0.4621613025665283,
0.6115528345108032,
0.17324960231781006,
0.09665592759847641,
0.22021354734897614,
-0.31704211235046387,
-0.30478954315185547,
0.7791585922241211,
0.35370853543281555,
0.513141930103302,
-0.3786376416683197,
-0.3971727192401886,
-0.1687210351228714,
0.6253336668014526,
-0.10074809193611145,
0.3334043622016907,
-0.059729378670454025,
0.4164307713508606,
0.26373741030693054,
-0.22201968729496002,
0.289819598197937,
0.45002424716949463,
-0.5413088798522949,
-0.2921142876148224,
0.3170697093009949,
-0.8208420872688293,
-0.3273698687553406,
0.29810577630996704,
-0.5197329521179199,
0.7420881390571594,
-0.06827180832624435,
0.5183095932006836,
-0.3749501705169678,
0.47842809557914734,
0.46393582224845886,
-0.040217626839876175,
0.266002357006073,
-0.07035500556230545,
-0.046122752130031586,
0.36734887957572937,
-0.5204797387123108,
0.1671278178691864,
-0.19585569202899933,
-0.28148114681243896,
-0.1426733136177063,
0.3894835412502289,
-0.12221144139766693,
0.2642589807510376,
-0.3986503779888153,
0.08926931023597717,
0.0911659300327301,
-0.41984331607818604,
-0.14311103522777557,
0.19498656690120697,
-0.2601896822452545,
-0.02034119702875614,
0.22604559361934662,
0.3749164938926697,
-0.13834641873836517,
-0.6179196238517761,
0.3807314932346344,
0.383577436208725,
0.023599451407790184,
0.21236158907413483,
-0.22192326188087463,
0.2124851793050766,
0.20835871994495392,
0.40102508664131165,
-0.14187848567962646,
0.5589141845703125,
0.05261263996362686,
0.292807936668396,
-1.0679813623428345,
0.47643986344337463,
-0.6132124662399292,
-0.2639896273612976,
-0.6002296805381775,
-0.05573470517992973,
0.38454669713974,
0.3822195529937744,
-0.4165908992290497,
-0.058031924068927765,
-0.400494784116745,
0.7698540091514587,
-0.020345065742731094,
-0.1939713954925537,
0.1899079978466034,
-0.39280474185943604,
-0.33116984367370605,
-0.5641656517982483,
0.40915945172309875,
0.11381147056818008,
0.17670004069805145,
-0.5997581481933594,
0.4485529959201813,
0.40852081775665283,
-0.6471377611160278,
0.208953857421875,
-0.01832100749015808,
0.45021936297416687,
-0.2861137092113495,
0.6895918250083923,
-0.5376144051551819,
0.062381766736507416,
-0.27984419465065,
0.12905414402484894,
-0.19999733567237854,
-0.3508739471435547,
0.24887272715568542,
-0.08119115978479385,
-0.06362749636173248,
-0.0840582624077797,
0.06550892442464828,
0.07644369453191757,
-0.056983787566423416,
-0.48927345871925354,
-0.7042998671531677,
-0.1910140961408615,
-0.12081983685493469,
-0.8539491295814514,
0.3571147918701172,
-0.528743326663971,
-0.19574694335460663,
0.13164521753787994,
0.14598366618156433,
-0.4923590123653412,
-0.28048181533813477,
0.26194795966148376
] |
Hes and Hey genes are the mammalian counterparts of the Hairy and Enhancer-of-split type of genes in Drosophila and they represent the primary targets of the Delta-Notch signaling pathway. Hairy-related factors control multiple steps of embryonic development and misregulation is associated with various defects. Hes and Hey genes (also called Hesr, Chf, Hrt, Herp or gridlock) encode transcriptional regulators of the basic helix-loop-helix class that mainly act as repressors. The molecular details of how Hes and Hey proteins control transcription are still poorly understood, however. Proposed modes of action include direct binding to N- or E-box DNA sequences of target promoters as well as indirect binding through other sequence-specific transcription factors or sequestration of transcriptional activators. Repression may rely on recruitment of corepressors and induction of histone modifications, or even interference with the general transcriptional machinery. All of these models require extensive protein-protein interactions. Here we review data published on protein-protein and protein-DNA interactions of Hairy-related factors and discuss their implications for transcriptional regulation. In addition, we summarize recent progress on the identification of potential target genes and the analysis of mouse models. | [
-0.022050119936466217,
0.002965488936752081,
-0.011596499010920525,
0.022705748677253723,
0.010420616716146469,
-0.0042504603043198586,
0.010100974701344967,
-0.006725871004164219,
-0.01074167899787426,
-0.012599889189004898,
-0.005543656647205353,
-0.006051893346011639,
-0.006989848334342241,
0.011467017233371735,
0.013002326712012291,
-0.0019044103100895882,
0.010729567147791386,
0.022135160863399506,
0.009934981353580952,
-0.02623772993683815,
0.023546326905488968,
0.006143538281321526,
0.008269073441624641,
-0.020464226603507996,
0.009313855320215225,
-0.005024550948292017,
0.030028801411390305,
0.006569183897227049,
-0.008031620644032955,
0.008368421345949173,
0.010175062343478203,
-0.009750647470355034,
0.018490789458155632,
0.011962096206843853,
0.005212841555476189,
0.0063547915779054165,
-0.0037579811178147793,
0.017769748345017433,
0.046944379806518555,
-0.0056223636493086815,
-0.02424120530486107,
-0.00941715482622385,
0.0018832703353837132,
-0.014973297715187073,
-0.004098248668015003,
0.0018150350078940392,
-0.004345722962170839,
0.008648600429296494,
-0.0010207602754235268,
0.0031393144745379686,
-0.020173899829387665,
-0.013795986771583557,
-0.014332348480820656,
0.023597057908773422,
-0.005298534873872995,
0.0027765182312577963,
0.015237314626574516,
0.008975251577794552,
0.010793539695441723,
-0.01097983866930008,
-0.010283432900905609,
-0.006746453233063221,
0.026778563857078552,
0.010592696256935596,
-0.019809288904070854,
-0.06725288927555084,
0.028958549723029137,
0.010746192187070847,
-0.0016936511965468526,
-0.015706339851021767,
-0.006405360996723175,
0.01219777762889862,
0.016143418848514557,
-0.04542367905378342,
-0.002155420370399952,
-0.00010105548426508904,
-0.0030992182437330484,
0.0002515059895813465,
0.011651060543954372,
0.003961755894124508,
-0.0060909828171133995,
-0.006786009296774864,
0.018245700746774673,
-0.004042092245072126,
0.010815611109137535,
0.0027212784625589848,
-0.02102130651473999,
-0.01833527721464634,
0.024769991636276245,
-0.020203549414873123,
-0.013010707683861256,
-0.007868697866797447,
-0.02434808388352394,
-0.013815089128911495,
-0.022154616191983223,
-0.005167914554476738,
-0.0016605396522209048,
-0.00230965088121593,
0.017963558435440063,
-0.0168968066573143,
-0.0018347945297136903,
0.0012401762651279569,
0.008653438650071621,
-0.0005681762704625726,
0.013695413246750832,
0.01149770524352789,
0.0069498480297625065,
-0.004236409906297922,
0.012328622862696648,
0.015263444744050503,
-0.01291162334382534,
0.024214202538132668,
-0.016426805406808853,
-0.02098219469189644,
0.01921572908759117,
0.025562720373272896,
-0.01996990293264389,
0.011901596561074257,
0.011367358267307281,
-0.0021072453819215298,
0.006661061197519302,
0.00034282286651432514,
0.013601161539554596,
-0.006238683592528105,
0.006691498216241598,
-0.026927562430500984,
-0.013486901298165321,
-0.001104113645851612,
-0.012578657828271389,
0.004289897624403238,
-0.00817100889980793,
0.007636653259396553,
-0.010131324641406536,
-0.034277357161045074,
-0.006400538608431816,
-0.016688097268342972,
0.010885372757911682,
0.012706791050732136,
-0.01703948713839054,
-0.006128042936325073,
0.008669303730130196,
0.002024962566792965,
0.011371217668056488,
0.006260896101593971,
0.0060771615244448185,
0.002215304411947727,
0.014415695331990719,
-0.004498166963458061,
0.01758691295981407,
-0.001038234680891037,
-0.0008629611111246049,
0.0009687788551673293,
-0.0033619836904108524,
-0.009107156656682491,
-0.006687027867883444,
0.028851617127656937,
-0.005696585401892662,
-0.021135615184903145,
0.0021662521176040173,
0.0077059101313352585,
0.003910979256033897,
-0.0055267103016376495,
0.01464077178388834,
0.007787497714161873,
-0.021928846836090088,
0.01440784614533186,
-0.00820823386311531,
0.008710608817636967,
0.008998502977192402,
0.0075542256236076355,
-0.0056145587004721165,
0.001133322948589921,
0.020519863814115524,
0.0022763346787542105,
0.0019484730437397957,
-0.011777281761169434,
0.027779053896665573,
0.005732442252337933,
-0.025751743465662003,
0.0669998750090599,
0.004371607210487127,
0.02052154764533043,
-0.01593485102057457,
0.02449830248951912,
-0.002013665623962879,
0.0011102505959570408,
0.012711840681731701,
-0.0022544558160007,
-0.007547343615442514,
-0.00023179507115855813,
-0.013063434511423111,
0.006388956215232611,
-0.002534401137381792,
0.011646137572824955,
-0.005976731423288584,
0.0037369616329669952,
-0.01221285667270422,
0.012635800056159496,
0.00793847069144249,
0.0075272382237017155,
0.024418311193585396,
0.0017969447653740644,
0.01871456578373909,
-0.0044182902202010155,
-0.00960501842200756,
-0.0009178589098155499,
0.004542786628007889,
0.0006181048229336739,
0.01953345164656639,
0.04116440564393997,
-0.009575850330293179,
0.0076996926218271255,
-0.013995983637869358,
-0.010380207560956478,
0.027769312262535095,
0.02032095193862915,
-0.008622397668659687,
0.02014295756816864,
0.029336778447031975,
-0.010130295529961586,
0.002109353430569172,
-0.0015675819013267756,
0.0022975285537540913,
-0.018331721425056458,
-0.010321313515305519,
-0.017672482877969742,
0.006881393492221832,
0.016653869301080704,
-0.04559372365474701,
0.014362095855176449,
-0.01115295197814703,
-0.002627922222018242,
-0.009289816953241825,
0.029665015637874603,
0.02725311741232872,
0.019232939928770065,
0.006618543528020382,
0.01627904176712036,
0.0034772248473018408,
-0.0061799753457307816,
-0.01570923998951912,
0.0024761320091784,
0.0066305166110396385,
-0.033118702471256256,
-0.005958892405033112,
0.01217283308506012,
0.012635120190680027,
0.001516707707196474,
0.001369181089103222,
-0.02334972470998764,
0.006696128286421299,
-0.007491578347980976,
-0.0011567543260753155,
-0.001411919016391039,
0.004419742617756128,
-0.002699221484363079,
0.02696037106215954,
0.018610263243317604,
0.02370953932404518,
0.0006200140342116356,
-0.004338664934039116,
0.008666951209306717,
-0.002602045191451907,
-0.006135950330644846,
-0.02670157514512539,
-0.0037126727402210236,
-0.019938062876462936,
0.014500336721539497,
0.0143408989533782,
-0.013003774918615818,
0.007627023383975029,
-0.00697953999042511,
-0.003506231587380171,
-0.08179406076669693,
-0.007762866094708443,
-0.011235814541578293,
0.031692102551460266,
0.004553573671728373,
0.0005392055027186871,
-0.004964272957295179,
0.011781750246882439,
-0.013695470988750458,
-0.006925668567419052,
0.02192576788365841,
0.00407430250197649,
-0.013494787737727165,
-0.010215498507022858,
0.005696647800505161,
-0.00820309016853571,
0.005081772338598967,
0.00564256077632308,
-0.01613808609545231,
-0.014491066336631775,
-0.017931098118424416,
-0.004507058300077915,
-0.015942713245749474,
0.01584653928875923,
-0.03145484998822212,
-0.007316083647310734,
-0.015395989641547203,
-0.017818745225667953,
-0.005470635369420052,
0.002180628478527069,
-0.02900049276649952,
-0.006310638971626759,
0.023570550605654716,
-0.005766055081039667,
0.00478840246796608,
-0.010882933624088764,
-0.011471559293568134,
-0.003372733946889639,
-0.010773585177958012,
0.01138127502053976,
-0.04130598157644272,
0.0194039735943079,
0.012499496340751648,
-0.0075073763728141785,
0.01204681396484375,
0.008242732845246792,
-0.002644547261297703,
-0.011737670749425888,
0.016269657760858536,
0.008454670198261738,
0.013975992798805237,
-0.008081169798970222,
0.01738208904862404,
0.007872410118579865,
0.005670730024576187,
0.007396110333502293,
-0.013967962004244328,
0.021077174693346024,
-0.012231975793838501,
-0.009440499357879162,
0.03551080822944641,
0.014588898979127407,
-0.009386565536260605,
-0.012876028195023537,
0.03378106281161308,
-0.02127326838672161,
0.010164296254515648,
-0.014315737411379814,
-0.009890291839838028,
0.004686042200773954,
0.03371574357151985,
-0.005980395246297121,
0.009226764552295208,
0.0008631290402263403,
-0.03194328397512436,
-0.012762628495693207,
-0.008591964840888977,
-0.004329354502260685,
0.00692778080701828,
-0.0028066120576113462,
-0.017353452742099762,
0.006533538922667503,
-0.008539248257875443,
-0.001867304788902402,
-0.021024297922849655,
-0.03553348779678345,
-0.0015148019883781672,
0.01136842742562294,
0.013338757678866386,
-0.016170985996723175,
0.0020450963638722897,
-0.01384345255792141,
0.029813090339303017,
0.015349045395851135,
0.013666350394487381,
-0.033435821533203125,
0.027541832998394966,
0.018457897007465363,
-0.01339571550488472,
0.006928104907274246,
-0.028283510357141495,
0.003064066171646118,
0.008572151884436607,
-0.009807665832340717,
0.010457418859004974,
0.014729957096278667,
0.0009313098853453994,
-0.019839143380522728,
0.0037220341619104147,
-0.0032506054267287254,
0.012528277933597565,
-0.03671064227819443,
-0.009677103720605373,
-0.010657088831067085,
0.01386980526149273,
-0.03460758179426193,
-0.0046624247916042805,
0.01109132170677185,
0.07274839282035828,
0.017503608018159866,
-0.013721330091357231,
-0.002618008991703391,
0.007446281611919403,
-0.018884088844060898,
0.004689304158091545,
0.01250031590461731,
-0.00898498110473156,
0.0010098358616232872,
0.011643078178167343,
-0.0020140414126217365,
-0.015114805661141872,
-0.009242425672709942,
0.00005762421642430127,
-0.015702983364462852,
-0.02045113779604435,
-0.014099924825131893,
0.011404216289520264,
0.0073991334065794945,
0.008029189892113209,
-0.015048420056700706,
-0.001577936578541994,
0.00040792464278638363,
0.00444895401597023,
-0.025857696309685707,
-0.020025203004479408,
-0.015117229893803596,
-0.0027793801855295897,
0.00931641273200512,
0.018001960590481758,
-0.026972148567438126,
-0.008793752640485764,
-0.0016154851764440536,
-0.001103653572499752,
0.003402309725061059,
0.0239124558866024,
0.009168779477477074,
-0.01971382275223732,
0.00400990154594183,
0.014273015782237053,
-0.01832621917128563,
0.0021042104344815016,
0.013083262369036674,
-0.011555291712284088,
0.02737184800207615,
0.008855323307216167,
-0.004321352578699589,
0.0028719049878418446,
0.0028904136270284653,
0.0020769350230693817,
0.00250071007758379,
0.007284268736839294,
-0.018281372264027596,
0.03370041400194168,
-0.008044211193919182,
0.012040846981108189,
0.0004671452334150672,
0.0031213341280817986,
0.0027005919255316257,
-0.03338751196861267,
-0.02460518479347229,
-0.004375247750431299,
0.0013462221249938011,
0.005702626891434193,
-0.0029799570329487324,
-0.005329729989171028,
-0.006455003749579191,
0.01186218298971653,
0.0004526462871581316,
0.023673007264733315,
0.0009414867963641882,
-0.018324915319681168,
-0.007077896036207676,
-0.015499301254749298,
0.0010983363026753068,
0.0020220906008034945,
0.0038351905532181263,
0.013295570388436317,
0.005270554218441248,
0.01579943113029003,
0.005358327180147171,
0.01709233596920967,
-0.006234109867364168,
-0.005207885056734085,
0.01073487475514412,
-0.015336137264966965,
-0.07530498504638672,
-0.031756315380334854,
0.009893221780657768,
-0.0060216751880943775,
0.01136245671659708,
-0.015449518337845802,
-0.00254320097155869,
0.016750678420066833,
-0.001137457205913961,
0.00006906536873430014,
0.010431335307657719,
-0.028327908366918564,
-0.005634472705423832,
0.023272205144166946,
0.007403465919196606,
0.01596164144575596,
0.012080585584044456,
-0.004602508153766394,
-0.0161738283932209,
0.004402946215122938,
-0.027579743415117264,
-0.0251229926943779,
0.004493062384426594,
0.00225936365313828,
-0.0053308382630348206,
-0.08160006999969482,
-0.011614151298999786,
-0.007092371582984924,
-0.028586354106664658,
0.0042958492413163185,
-0.002978348173201084,
-0.0005300554912537336,
-0.017918996512889862,
-0.046890757977962494,
-0.01910734921693802,
-0.03152753785252571,
-0.0024043056182563305,
-0.03943389654159546,
0.000621085288003087,
0.018048688769340515,
-0.013236324302852154,
0.0068270801566541195,
-0.0022901329211890697,
-0.01119422260671854,
-0.0045731342397630215,
-0.0284707210958004,
0.007929752580821514,
-0.011759827844798565,
0.0072169979102909565,
-0.007934298366308212,
-0.009710745885968208,
0.003737390972673893,
0.013075768947601318,
-0.0023947134613990784,
0.013247482478618622,
-0.020727258175611496,
-0.011197446845471859,
-0.008034774102270603,
-0.0158800408244133,
-0.0028970090206712484,
-0.023428183048963547,
0.019602913409471512,
-0.025156376883387566,
-0.021489914506673813,
0.008182422257959843,
-0.0048639364540576935,
-0.002022683620452881,
0.008742574602365494,
0.007445734925568104,
-0.009891795925796032,
-0.0370832234621048,
0.0057731554843485355,
-0.004442117176949978,
0.004124457482248545,
0.0038331442046910524,
0.012011304497718811,
-0.004847906529903412,
0.012893355451524258,
-0.0029516336508095264,
-0.0028222003020346165,
0.008041677996516228,
-0.005351948086172342,
0.02941582351922989,
0.012583605945110321,
-0.0011453541228547692,
-0.00047422631178051233,
-0.009636635892093182,
0.014894861727952957,
0.07217587530612946,
-0.003000702243298292,
0.018435269594192505,
-0.022075388580560684,
0.00007787579670548439,
0.0030966750346124172,
-0.012236209586262703,
-0.006264913827180862,
-0.01611814647912979,
0.002427409403026104,
-0.013556862249970436,
-0.007549556903541088,
0.009420515969395638,
0.013803265988826752,
0.01775290071964264,
0.013875400647521019,
0.01260489784181118,
0.01862243562936783,
-0.012888774275779724,
0.00043300166726112366,
-0.0034089297987520695,
-0.01853363774716854,
0.013392407447099686,
-0.000056037213653326035,
0.01596665568649769,
0.00027221208438277245,
-0.026690173894166946,
0.02416914701461792,
-0.02738223411142826,
0.03543376177549362,
-0.0038906794507056475,
-0.02723091095685959,
0.0004892367287538946,
0.004547180607914925,
-0.00022697506938129663,
0.000442389864474535,
0.009709859266877174,
0.006862537935376167,
0.012438304722309113,
-0.004371039103716612,
-0.0028233788907527924,
-0.010283180512487888,
0.001050782622769475,
-0.033001817762851715,
0.022301504388451576,
-0.028084490448236465,
0.003510259324684739,
0.007784738205373287,
0.007279383018612862,
0.012023700401186943,
0.05663406848907471,
-0.0016707316972315311,
0.00009682812378741801,
-0.02978406473994255,
-0.005677131935954094,
0.027710767462849617,
0.008874934166669846,
0.0018311041640117764,
0.004880378022789955,
0.03025616519153118,
0.020711567252874374,
-0.009348967112600803,
-0.004738624207675457,
-0.00825379230082035,
0.007892404682934284,
-0.01062806323170662,
-0.027134360745549202,
-0.007754677906632423,
0.018688416108489037,
0.01743047684431076,
0.011126242578029633,
-0.0032834031153470278,
0.006079281680285931,
-0.014746956527233124,
0.013017350807785988,
0.015385232865810394,
0.011466015130281448,
0.012600766494870186,
0.020007532089948654,
0.0020281062461435795,
-0.0074172550812363625,
0.010676348581910133,
0.010196875780820847,
-0.002275497652590275,
-0.021964091807603836,
0.0271734781563282,
0.03428873047232628,
-0.02862260304391384,
-0.0024057216942310333,
0.00811498798429966,
0.023360006511211395,
-0.00636490760371089,
0.00849842093884945,
0.012550342828035355,
0.011014511808753014,
0.03428670018911362,
-0.0076087662018835545,
0.007240822073072195,
-0.01633143611252308,
0.024425795301795006,
0.009615413844585419,
0.019139286130666733,
-0.000555504928342998,
-0.0031357042025774717,
-0.019588656723499298,
0.005578943528234959,
-0.038028646260499954,
-0.017615918070077896,
0.009560310281813145,
-0.0021960409358143806,
0.02149134688079357,
-0.0014628367498517036,
0.006254823878407478,
-0.01193140633404255,
0.003183517372235656,
0.02587052620947361,
-0.0035369275137782097,
-0.016036411747336388,
-0.0014770177658647299,
-0.013858694583177567,
-0.00028640893287956715,
0.003887330647557974,
-0.005954662337899208,
0.0013663065619766712,
0.028189968317747116,
-0.010473430156707764,
-0.008442699909210205,
0.03434789925813675,
-0.02852744236588478,
-0.002061823382973671,
0.007958241738379002,
-0.0181414857506752,
0.010732188820838928,
0.013111336156725883,
0.005252431146800518,
0.0016499701887369156,
-0.001558096380904317,
0.007029587868601084,
-0.004010653123259544,
0.021338023245334625,
0.0005020152311772108,
0.006481795571744442,
-0.0016810884699225426,
0.017270110547542572,
0.006915900856256485,
-0.015113888308405876,
0.002642367035150528,
0.006014642305672169,
-0.0007906584069132805,
0.011381205171346664,
0.023456014692783356,
0.004013604484498501,
-0.0020775669254362583,
-0.011834715493023396,
-0.004212827421724796,
0.026656407862901688,
0.013259707018733025,
-0.013462355360388756,
-0.022387631237506866,
0.0060148597694933414,
-0.0077588907442986965,
-0.006593327037990093,
0.012414058670401573,
-0.004680918995290995,
0.01335407979786396,
-0.013019836507737637,
-0.025171121582388878,
0.005890998058021069,
0.0021609377581626177,
-0.008904486894607544,
0.03367228806018829,
0.013002295047044754,
0.00970897264778614,
0.01476149633526802,
-0.02096116542816162,
-0.008419794961810112,
-0.016581468284130096,
0.008541646413505077,
0.003867048304527998,
-0.006508916616439819,
0.01917582005262375,
0.004281061701476574,
0.003616920206695795,
-0.007701386697590351,
0.007589168846607208,
-0.02983231469988823,
-0.003048710525035858,
-0.007939491420984268,
-0.011668466031551361,
-0.009892051108181477,
0.012541646137833595,
0.00886370800435543,
-0.012060324661433697,
0.018414117395877838,
0.006046778988093138,
-0.0013598629739135504,
0.009477141313254833,
-0.0076675619930028915,
0.017554890364408493,
0.008350132033228874,
0.0037212336901575327,
-0.013458097353577614
] | [
0.23654556274414062,
0.0447801910340786,
0.1084430143237114,
0.06525072455406189,
-0.04160599783062935,
0.1849163919687271,
-0.21272578835487366,
-0.10925140231847763,
-0.21103516221046448,
-0.3042072355747223,
-0.19421085715293884,
-0.17963650822639465,
-0.7405315637588501,
0.16747626662254333,
-0.3768455982208252,
0.5698993802070618,
0.0996273010969162,
0.5372257828712463,
-0.37932685017585754,
-0.5118176937103271,
0.11638391762971878,
-0.4315407872200012,
0.15716169774532318,
0.07269616425037384,
0.6321009993553162,
0.17772158980369568,
-0.06826291233301163,
-0.6900666356086731,
0.6521232724189758,
0.22523583471775055,
0.1465545892715454,
0.5244587063789368,
0.02199709787964821,
0.084893137216568,
-0.5483470559120178,
0.08142590522766113,
-0.7859819531440735,
0.09697142988443375,
0.3415561616420746,
0.25973743200302124,
-0.4199618399143219,
-0.6198457479476929,
-0.8482658267021179,
0.304178923368454,
-0.32441970705986023,
-0.25433576107025146,
-1.4016435146331787,
0.6783499717712402,
-0.2548704743385315,
0.08918318152427673,
-0.5268253684043884,
0.4932337999343872,
0.029607312753796577,
0.06020989269018173,
0.45288461446762085,
-0.30062395334243774,
-0.09028483927249908,
-0.004427437670528889,
0.07017777860164642,
-1.040209174156189,
-0.08281808346509933,
-0.05809518322348595,
-0.08486869931221008,
0.05326652526855469,
0.16728074848651886,
0.5384540557861328,
-0.08954320847988129,
-0.5930725336074829,
-0.48947644233703613,
-0.06155364587903023,
-0.21124552190303802,
-0.2615198791027069,
-0.1623845398426056,
0.43015849590301514,
0.562246561050415,
0.21649211645126343,
-0.1959991157054901,
-0.15060405433177948,
0.053686149418354034,
0.33022910356521606,
0.024272384122014046,
0.08750113844871521,
0.21762949228286743,
0.28545835614204407,
0.2350713163614273,
0.33598464727401733,
-0.26370057463645935,
0.428292840719223,
-0.35629016160964966,
-0.20540915429592133,
-0.1543608456850052,
-0.26160502433776855,
0.5928414463996887,
-0.06725075095891953,
0.1333329826593399,
0.7884419560432434,
0.5678133964538574,
-0.17869997024536133,
-0.10465735197067261,
0.057233601808547974,
-0.2339663952589035,
0.18802045285701752,
0.5370491147041321,
-0.9433483481407166,
-0.7070044279098511,
-0.2774389386177063,
0.10377376526594162,
-0.8398301005363464,
-0.41558703780174255,
-0.1691364049911499,
-0.7320290207862854,
0.12300083041191101,
-0.0032058977521955967,
-0.02959577739238739,
0.5021488070487976,
0.557675302028656,
0.02036154270172119,
-0.2916841208934784,
0.25918814539909363,
0.5085815191268921,
-0.6900164484977722,
1.0704388618469238,
-0.1555171012878418,
1.0121357440948486,
0.2644641697406769,
0.18572479486465454,
-0.2339736372232437,
-0.24256005883216858,
-0.1719440221786499,
0.4627026915550232,
0.2292693853378296,
0.6921709775924683,
-0.20115742087364197,
0.06424718350172043,
-0.4234568476676941,
0.3623949885368347,
0.46129000186920166,
0.20840755105018616,
0.24585199356079102,
0.08284888416528702,
-0.40725022554397583,
-0.22160059213638306,
0.03950246050953865,
-0.6151857972145081,
-0.011052025482058525,
-0.7039746642112732,
-0.4242761433124542,
-0.19451874494552612,
0.3367656171321869,
-0.18629774451255798,
-0.02415117435157299,
-0.5310791730880737,
-0.31929853558540344,
-0.35770490765571594,
-0.19440649449825287,
0.6068874001502991,
0.449768990278244,
-0.23317471146583557,
0.2753957211971283,
0.08836600929498672,
-0.055313389748334885,
-0.09555958956480026,
-0.5019007325172424,
-0.018124205991625786,
0.19389840960502625,
0.08530674874782562,
0.585089921951294,
0.36925870180130005,
-0.4519144594669342,
-0.20019042491912842,
-0.05990638583898544,
-0.38128581643104553,
0.5316906571388245,
-0.41408103704452515,
-0.1384744644165039,
-0.2261698842048645,
-0.14824897050857544,
-0.006387434434145689,
0.4543513059616089,
0.10760659724473953,
-0.8777962327003479,
-0.26314687728881836,
-0.07189449667930603,
-0.18455156683921814,
0.011551137082278728,
0.24943827092647552,
0.5390805602073669,
-0.28353118896484375,
-0.12625686824321747,
-0.09185392409563065,
0.007588184904307127,
-0.08386152237653732,
0.5072828531265259,
-0.24213823676109314,
1.3599861860275269,
-0.4641037583351135,
0.12325701862573624,
0.8355893492698669,
0.09403897821903229,
0.3366290032863617,
-0.4754880368709564,
-0.6103955507278442,
0.4362971782684326,
-0.17454859614372253,
-0.8172756433486938,
-0.08715397119522095,
-0.46813634037971497,
0.15173779428005219,
0.011808675713837147,
-0.18881875276565552,
0.09375609457492828,
-0.3206859827041626,
0.24013938009738922,
0.03686600551009178,
0.27350810170173645,
-0.580782949924469,
0.2067176252603531,
0.006172836758196354,
-0.567257821559906,
-0.3909737467765808,
0.3010637164115906,
-0.533327579498291,
0.43474072217941284,
1.038122296333313,
0.11327674239873886,
0.5334169864654541,
1.219716191291809,
0.231971874833107,
0.7757391929626465,
-0.29015421867370605,
0.3645828366279602,
-0.6318213939666748,
0.22785553336143494,
-0.1523999571800232,
-0.36585041880607605,
-0.2209504395723343,
0.23600265383720398,
-0.0019334417302161455,
0.10857728123664856,
-0.6932806968688965,
-0.1571212112903595,
0.9886292219161987,
-0.4544981122016907,
-0.7061703205108643,
0.21199658513069153,
-0.7589864730834961,
-0.1356489658355713,
0.32291489839553833,
-1.0783777236938477,
0.1673535704612732,
-0.09756896644830704,
0.6954701542854309,
0.049827832728624344,
-0.7886945009231567,
0.4940483570098877,
0.14547701179981232,
0.14764314889907837,
0.16926178336143494,
0.11438533663749695,
-0.3820013701915741,
0.040017422288656235,
-0.510336697101593,
-0.21418684720993042,
-0.015533056110143661,
0.042753417044878006,
-0.4227961599826813,
-0.4048529863357544,
-0.08094850182533264,
1.0351108312606812,
0.8216774463653564,
1.0385003089904785,
0.1098809614777565,
-0.537691593170166,
-0.33147597312927246,
-0.09664537012577057,
-1.0337343215942383,
0.31560078263282776,
0.14178280532360077,
-0.18944725394248962,
-0.532950222492218,
0.09099308401346207,
0.22091294825077057,
0.7061963081359863,
0.0031378890853375196,
-0.05717402696609497,
-0.32801344990730286,
-0.36301732063293457,
-0.6402608156204224,
-0.17816127836704254,
-0.42085936665534973,
-0.14649105072021484,
0.6710478663444519,
-0.009784900583326817,
0.10151264816522598,
0.09689142554998398,
0.4426632225513458,
0.4601444602012634,
0.667292594909668,
0.6206990480422974,
0.18250305950641632,
-0.21136672794818878,
0.3222630023956299,
-0.20809625089168549,
-0.09042861312627792,
-0.024153582751750946,
0.40465596318244934,
-0.30136924982070923,
0.2493477463722229,
-5.619445323944092,
0.05446048825979233,
-0.04551404342055321,
-0.4722110331058502,
0.23447874188423157,
-0.251573383808136,
1.038969874382019,
0.11045573651790619,
0.3728482723236084,
0.32191821932792664,
0.38479697704315186,
0.1493285745382309,
-0.7497002482414246,
-0.30383238196372986,
0.05391394719481468,
-0.1710326224565506,
-0.16196267306804657,
-0.19983074069023132,
0.990195095539093,
-0.0900927186012268,
-0.03590273857116699,
-0.4118548333644867,
-0.19978132843971252,
0.4780673384666443,
-0.3280911445617676,
0.25308725237846375,
-0.7032950520515442,
-0.4980131983757019,
-0.4356198310852051,
-0.5095483064651489,
0.026023205369710922,
-0.4401732087135315,
-0.36051949858665466,
0.052899111062288284,
0.38227006793022156,
-0.3941643238067627,
0.25692039728164673,
0.18542249500751495,
-0.06857706606388092,
-0.21801957488059998,
0.6484121680259705,
0.42040976881980896,
0.029161807149648666,
-0.3293052017688751,
0.17360873520374298,
-0.15131862461566925,
-0.47316741943359375,
-0.04299480468034744,
-0.6235194206237793,
0.47814375162124634,
-0.280129998922348,
-0.11169496178627014,
0.12146776169538498,
0.6325861811637878,
0.9035128951072693,
0.6222931742668152,
-0.19534078240394592,
0.023531507700681686,
-0.28670960664749146,
-0.27468955516815186,
-0.2966417670249939,
-0.29615214467048645,
-0.8929873704910278,
-0.6939828395843506,
0.2188585251569748,
0.08070392906665802,
-0.5651358366012573,
-0.437408983707428,
0.5769322514533997,
-0.4489467740058899,
0.20301589369773865,
-0.30909037590026855,
0.04982885345816612,
-0.7968578934669495,
0.22523024678230286,
-0.6016786694526672,
0.533198356628418,
0.17330166697502136,
-0.16173262894153595,
0.008114298805594444,
-0.6036032438278198,
-0.07661882042884827,
-0.2386627346277237,
-0.18290385603904724,
0.040031783282756805,
-0.09691091626882553,
-0.5216246247291565,
-0.004752118140459061,
0.21879851818084717,
0.8110461831092834,
0.6953932642936707,
-0.2794313132762909,
-0.01214209757745266,
0.5605606436729431,
0.30811551213264465,
0.0839795172214508,
0.2326859086751938,
0.9287064671516418,
0.29610151052474976,
0.20283199846744537,
0.6182546615600586,
-0.044246383011341095,
-0.6172972321510315,
-0.664137065410614,
-0.14198186993598938,
0.4138837158679962,
-0.43774986267089844,
0.2996427118778229,
0.847411572933197,
-0.5765891075134277,
0.0693255066871643,
-0.07360002398490906,
-0.40944531559944153,
-0.11486271768808365,
0.4323822259902954,
-0.2833913266658783,
-0.12291185557842255,
0.4883440136909485,
0.7379233837127686,
-0.16038817167282104,
0.0036420191172510386,
0.19224430620670319,
-0.8919910788536072,
0.14794978499412537,
0.15011347830295563,
0.3487222194671631,
-0.27873873710632324,
0.2905842363834381,
-0.2830612063407898,
-0.16311538219451904,
0.3310461640357971,
-0.01641918532550335,
-0.3209211230278015,
0.2327663153409958,
0.264894962310791,
-0.1216873899102211,
-0.2811596691608429,
0.609856903553009,
0.34838220477104187,
0.03346998244524002,
0.14486636221408844,
0.0505794994533062,
0.23699374496936798,
0.043253686279058456,
0.4774644076824188,
-0.17349280416965485,
-0.5310683846473694,
0.051624845713377,
-0.32038089632987976,
-0.4220685064792633,
0.24048449099063873,
-0.4513012766838074,
-0.022197086364030838,
-0.06345710903406143,
0.4144299030303955,
0.2271956205368042,
0.32904762029647827,
0.4851682782173157,
0.4038446247577667,
-0.6570445895195007,
-0.025985876098275185,
0.33546724915504456,
-0.6056345701217651,
-0.09249414503574371,
-0.25592970848083496,
-0.35930708050727844,
0.3101331293582916,
-0.33969125151634216,
-0.5989362001419067,
0.10806219279766083,
-0.18553999066352844,
-0.09394824504852295,
-0.17934884130954742,
-0.0754937008023262,
-0.3302308917045593,
-0.4126718044281006,
-0.3567027151584625,
-0.06317595392465591,
-0.18824933469295502,
0.6207970380783081,
-0.43862736225128174,
-0.22649936378002167,
0.0002489479666110128,
0.29435017704963684,
0.1122172623872757,
0.25748544931411743,
0.17088472843170166,
-0.007526105269789696,
0.11457771062850952,
-0.37342727184295654,
0.1292710155248642,
-0.162265807390213,
-0.059390466660261154,
-0.1583515703678131,
-0.002009414602071047,
0.2644263207912445,
0.02758396975696087,
-0.368940532207489,
0.22951960563659668,
-1.0448904037475586,
0.2470867931842804,
0.2095891386270523,
-0.003379574278369546,
0.2706061005592346,
0.49266737699508667,
-0.15342648327350616,
-0.0498461090028286,
0.20314708352088928,
-0.261015385389328,
0.09526654332876205,
-0.12755700945854187,
-0.6657198071479797,
0.13096798956394196,
0.10199583321809769,
0.11847365647554398,
-0.39830997586250305,
0.2572176158428192,
-0.3708302974700928,
-0.1051565632224083,
0.4799869656562805,
0.2998727560043335,
-0.16115935146808624,
0.14134705066680908,
-0.021794507279992104,
-0.38303765654563904,
-0.32125920057296753,
-0.022549016401171684,
-0.7869494557380676,
0.831464409828186,
-0.25607138872146606,
0.0052978419698774815,
-0.011382420547306538,
0.01221509464085102,
0.49637559056282043,
-0.533331036567688,
-0.4330522119998932,
-0.43820181488990784,
0.2803284227848053,
0.30513206124305725,
0.5585811138153076,
0.317955881357193,
0.5885543823242188,
-0.35127589106559753,
-0.02959313988685608,
0.138558492064476,
0.7713522911071777,
0.3369743525981903,
-1.0173178911209106,
-0.32315924763679504,
0.24437633156776428,
0.40958258509635925,
-0.0544845275580883,
0.3808761239051819,
1.0250247716903687,
1.0899068117141724,
0.4334861934185028,
0.2449389398097992,
-0.2351999133825302,
-0.3554344177246094,
0.08311139047145844,
-0.6483398079872131,
0.2812068462371826,
0.02362038381397724,
0.12645915150642395,
-0.22858987748622894,
0.2705858051776886,
-0.41516757011413574,
-0.6505301594734192,
0.6070667505264282,
0.00748509680852294,
-0.227641299366951,
0.15242546796798706,
0.9405749440193176,
-0.1452474147081375,
-0.35119393467903137,
0.3757666051387787,
0.03129568323493004,
0.5436494946479797,
-0.16060420870780945,
0.19101551175117493,
-0.16686126589775085,
-0.5085144639015198,
0.8934151530265808,
-0.40530478954315186,
0.38711223006248474,
-0.7653088569641113,
0.13218551874160767,
-0.6803766489028931,
0.3221684396266937,
-0.18706990778446198,
-0.7764711976051331,
0.5433265566825867,
-0.6189647316932678,
-0.4082777202129364,
-0.24108010530471802,
-0.09279262274503708,
0.28979796171188354,
0.10622058063745499,
-0.04181669279932976,
0.16826093196868896,
-0.5077739953994751,
-0.038793835788965225,
0.45019158720970154,
0.019951079040765762,
-0.39471694827079773,
0.3218459188938141,
0.3717861473560333,
-0.006600695662200451,
-0.6926542520523071,
-0.5419780611991882,
-0.13986410200595856,
-0.35893338918685913,
0.46962663531303406,
-0.1760927140712738,
-0.14634442329406738,
0.40848422050476074,
-0.059901002794504166,
-0.0769132450222969,
0.3811693787574768,
0.28213393688201904,
0.38348010182380676,
0.2742008566856384,
0.6368457674980164,
-0.41092848777770996,
-0.129691019654274,
0.48126527667045593,
0.7415676116943359,
0.20995138585567474,
0.26088201999664307,
1.135317325592041,
0.30606016516685486,
0.17235636711120605,
0.33926793932914734,
0.8005589842796326,
0.28958624601364136,
-0.19956716895103455,
0.10628204047679901,
-0.2816593050956726,
0.11636834591627121,
-0.068153515458107,
0.39423778653144836,
0.5120247602462769,
-0.30103257298469543,
-0.2871819734573364,
0.3404851257801056,
0.24642996490001678,
0.23825599253177643,
0.20084843039512634,
0.22679255902767181,
0.9160224199295044,
0.05002699792385101,
-0.42863479256629944,
-0.7886671423912048,
0.6382080912590027,
-0.4952315092086792,
0.1568370759487152,
0.6637269258499146,
0.070573590695858,
-0.24116526544094086,
0.38267186284065247,
-0.47019603848457336,
-0.15220384299755096,
-0.13487116992473602,
0.7145295143127441,
-0.009604135528206825,
0.29668697714805603,
0.5077646374702454,
-0.005188917275518179,
0.5624836683273315,
0.1444963812828064,
-0.3118286728858948,
-0.11307744681835175,
0.07217627763748169,
0.14009277522563934,
0.026980038732290268,
-0.06943806260824203,
0.6493379473686218,
-0.3039258122444153,
-0.17271146178245544,
0.36345118284225464,
-0.19641366600990295,
0.02503364533185959,
-0.15379765629768372,
-0.7112249135971069,
-0.17283882200717926,
-0.6781367659568787,
-0.5329709053039551,
-0.26370784640312195,
-0.5244134664535522,
-0.05952712520956993,
0.08401759713888168,
-0.7478959560394287,
0.5940553545951843,
-0.17773239314556122,
0.5008822083473206,
0.29969528317451477,
-0.10008317977190018,
0.1262567937374115,
0.3378382623195648,
0.5061014890670776,
0.04158866032958031,
0.09190251678228378,
-0.21080371737480164,
-0.3519412875175476,
-0.2815658748149872,
0.4933461844921112,
-0.5131680965423584,
-0.22010618448257446,
0.016680490225553513,
-0.14631730318069458,
0.8616214394569397,
0.7703012228012085,
-0.21204514801502228,
0.41712960600852966,
-0.20251142978668213,
0.24696679413318634,
0.4079301059246063,
-0.4457029402256012,
0.05535079538822174,
-0.5300350189208984,
-0.02113957330584526,
-0.29586729407310486,
0.3169690668582916,
-0.07639548182487488,
-0.12036143243312836,
0.4278591573238373,
0.6042496562004089,
0.20324799418449402,
-0.6354522109031677,
0.7715145349502563,
-0.2534823715686798,
0.012150092981755733,
-0.21349629759788513,
-0.15384116768836975,
-0.47467753291130066,
-0.10419996082782745,
-0.9962342381477356,
0.019038425758481026,
0.1710270494222641,
-0.6101613640785217,
0.6383789777755737,
0.059222813695669174,
-0.30058202147483826,
-0.2273976057767868,
0.044562745839357376,
0.08600147068500519,
-0.70392245054245,
-1.1222950220108032,
-0.6111688017845154,
0.0822746530175209,
-0.25201737880706787,
-0.5311274528503418,
0.10523524880409241,
-0.06152207404375076,
0.10236302018165588,
0.17071430385112762,
0.04555772244930267,
-0.32331252098083496,
0.06639555841684341,
0.08879406750202179
] |
BACKGROUND Adult mammalian heart loses regeneration ability following ischemic injury due to the loss of cardiomyocyte mitosis. However, the molecular mechanisms underlying the post-mitotic nature of cardiomyocytes remain largely unknown. OBJECTIVES The purpose of this study was to define the essential role of long noncoding ribonucleic acids (lncRNAs) in heart regeneration during postnatal and adult injury. METHODS Myh6-driving cardiomyocyte-specific lncRNA-CAREL transgenic mice and adenovirus-mediated in vivo silencing of endogenous CAREL were used in this study. The effect of CAREL on cardiomyocyte replication and heart regeneration after apical resection or myocardial infarction was assessed by detecting mitosis and cytokinesis. RESULTS An lncRNA CAREL was found significantly up-regulated in cardiomyocytes from neonatal mice (P7) in parallel with loss of regenerative capacity. Cardiac-specific overexpression of CAREL in mice reduced cardiomyocyte division and proliferation and blunted neonatal heart regeneration after injury. Conversely, silencing of CAREL in vivo markedly promoted cardiac regeneration and improved heart functions after myocardial infarction in neonatal and adult mice. CAREL acted as a competing endogenous ribonucleic acid for miR-296 to derepress the expression of Trp53inp1 and Itm2a, the target genes of miR-296. Consistently, overexpression of miR-296 significantly increased cardiomyocyte replication and cardiac regeneration after injury. Decline of cardiac regenerative ability in CAREL transgenic mice was also rescued by miR-296. A short fragment containing the conserved sequence of CAREL reduced the proliferation of human induced pluripotent stem cell-derived cardiomyocytes as the full-length CAREL. CONCLUSIONS LncRNA CAREL regulates cardiomyocyte proliferation and heart regeneration in postnatal and adult heart after injury by acting as a competing endogenous ribonucleic acid on miR-296 that targets Trp53inp1 and Itm2a. | [
0.022276846691966057,
0.023117369040846825,
-0.008491333574056625,
0.011201499029994011,
0.0020391177386045456,
-0.016300879418849945,
0.011121060699224472,
0.012232797220349312,
-0.0169316865503788,
-0.01125128474086523,
-0.014901481568813324,
0.009727118536829948,
0.01885528676211834,
0.019109077751636505,
0.010512001812458038,
0.01800287887454033,
-0.019857682287693024,
0.040186796337366104,
0.015644792467355728,
0.000885797431692481,
-0.03376740962266922,
-0.0007981397211551666,
0.012444032356142998,
0.019373830407857895,
0.047478631138801575,
0.012831078842282295,
0.02599804848432541,
0.00724328588694334,
-0.003665492869913578,
-0.006487294100224972,
-0.0051454282365739346,
0.0345381535589695,
0.006760455667972565,
0.02213893085718155,
0.015472985804080963,
0.00556754507124424,
-0.007103285286575556,
0.03606225550174713,
0.06834439188241959,
-0.004748750478029251,
0.04061444476246834,
-0.014772084541618824,
0.017137445509433746,
0.00206036027520895,
-0.014029432088136673,
-0.006204743403941393,
0.007706005126237869,
0.0075505515560507774,
-0.006184901110827923,
0.009050448425114155,
0.0032710719387978315,
-0.0590115562081337,
-0.01127086952328682,
0.009796518832445145,
-0.007589616347104311,
-0.01530673447996378,
0.02341591753065586,
0.019320156425237656,
0.022555366158485413,
-0.0008089093025773764,
-0.005762611981481314,
0.00783276092261076,
-0.03309080749750137,
-0.02695475146174431,
0.006201774347573519,
-0.06574173271656036,
-0.03306509926915169,
0.020882248878479004,
-0.024653147906064987,
0.01556931622326374,
0.015597650781273842,
0.003067473880946636,
-0.0035630143247544765,
-0.01241188496351242,
0.00907986145466566,
-0.00012907525524497032,
0.005283431150019169,
-0.01740271784365177,
0.006909347604960203,
0.002914106473326683,
-0.05717161297798157,
-0.011745745316147804,
0.02255527302622795,
0.025313198566436768,
0.012008234858512878,
0.028562331572175026,
-0.0350741483271122,
-0.01538148894906044,
0.04961042106151581,
-0.022936899214982986,
0.030033256858587265,
0.04088868200778961,
-0.04324868321418762,
-0.01018652692437172,
-0.02670862153172493,
0.01186958234757185,
0.0013873314019292593,
0.03537041321396828,
0.011414770968258381,
-0.006790310610085726,
-0.03280378505587578,
0.025039639323949814,
0.018004659563302994,
-0.01360330916941166,
-0.03399024158716202,
0.008160008117556572,
0.037691473960876465,
0.03729484975337982,
0.03177019953727722,
0.018202947452664375,
-0.0030543094035238028,
-0.016166167333722115,
0.002065528417006135,
0.011098671704530716,
0.019819119945168495,
-0.0014975036028772593,
0.008568743243813515,
0.0010758629068732262,
0.014924267306923866,
0.014325221069157124,
0.008441193029284477,
0.02104661986231804,
-0.013894238509237766,
0.03454027324914932,
-0.0011670971289277077,
0.03476642072200775,
-0.0025052963756024837,
-0.0027350145392119884,
-0.03175542876124382,
0.013030974194407463,
-0.014308804646134377,
0.00787163432687521,
-0.018395263701677322,
-0.007686397060751915,
-0.017023663967847824,
0.0056555490009486675,
-0.01449419092386961,
-0.032224223017692566,
-0.014560858719050884,
-0.011155815795063972,
0.022421417757868767,
0.009801097214221954,
-0.008076128549873829,
0.007333917543292046,
0.005778464488685131,
-0.012993836775422096,
-0.0002221064642071724,
0.009863130748271942,
0.02202577330172062,
-0.019325561821460724,
-0.011086486279964447,
-0.002560590859502554,
0.018120769411325455,
-0.009933775290846825,
-0.02756790816783905,
0.0085791926831007,
-0.03239965811371803,
-0.035232990980148315,
-0.009154656901955605,
0.04340223968029022,
-0.03050415590405464,
-0.0038762984331697226,
0.004721934907138348,
0.013439418748021126,
0.021820468828082085,
-0.001946471631526947,
0.024227794259786606,
-0.015941303223371506,
0.0015337737277150154,
0.007647673133760691,
-0.005752316676080227,
0.025352133437991142,
0.028272679075598717,
0.010044306516647339,
0.021207932382822037,
-0.009125870652496815,
-0.00869695469737053,
0.01149007584899664,
-0.011430256068706512,
0.0653403252363205,
0.003057184163480997,
0.027391226962208748,
0.010608583688735962,
0.006305832415819168,
0.00945860892534256,
-0.0033022346906363964,
0.024088123813271523,
-0.005515868775546551,
0.0024513741955161095,
-0.01840408705174923,
0.005243674851953983,
-0.03012160398066044,
-0.0063166432082653046,
0.005549055524170399,
0.01380860060453415,
0.0023878617212176323,
0.012499146163463593,
0.011245336383581161,
0.01832958683371544,
-0.005921937525272369,
0.00006744172424077988,
-0.008426261134445667,
0.019366949796676636,
-0.04855623096227646,
-0.017258470878005028,
-0.0005564474849961698,
0.01723160594701767,
0.0006607200484722853,
-0.001726190559566021,
0.01175952423363924,
0.0152312982827425,
-0.019956884905695915,
-0.024633731693029404,
0.00001922203227877617,
0.003136354498565197,
0.016423458233475685,
-0.019617661833763123,
0.023843951523303986,
0.02564757689833641,
-0.011990223079919815,
0.004145377781242132,
0.02307741343975067,
-0.018430054187774658,
-0.02591797523200512,
-0.004453716799616814,
0.008987478911876678,
-0.004133926704525948,
0.020375289022922516,
0.025397546589374542,
0.015957586467266083,
-0.012798434123396873,
-0.05218106508255005,
-0.015160776674747467,
-0.01260301936417818,
0.024710247293114662,
-0.005518751218914986,
0.017535150051116943,
-0.030439455062150955,
0.013467052951455116,
-0.012051373720169067,
-0.023538602516055107,
-0.000574733130633831,
-0.016756262630224228,
-0.032133013010025024,
0.03862304612994194,
-0.011858581565320492,
-0.033397525548934937,
-0.009493272751569748,
0.02364508993923664,
-0.03894701600074768,
0.013592091389000416,
0.018115205690264702,
-0.016054941341280937,
0.018030593171715736,
-0.006972792558372021,
-0.024413028731942177,
0.0019406052306294441,
0.009941334836184978,
0.026231417432427406,
0.0058431546203792095,
0.0037306935992091894,
0.009136324748396873,
-0.014979538507759571,
-0.0038730581291019917,
-0.046499427407979965,
-0.006101267412304878,
0.0016447962261736393,
0.0022668836172670126,
-0.012646718882024288,
0.020396314561367035,
0.016303041949868202,
-0.013375034555792809,
-0.00910255778580904,
-0.07980868220329285,
-0.017101770266890526,
-0.015586706809699535,
0.01297113485634327,
0.0038349449168890715,
-0.011601063422858715,
-0.018854647874832153,
-0.014946097508072853,
0.0009995722211897373,
-0.015807421877980232,
-0.040713101625442505,
0.013601425103843212,
-0.012951692566275597,
0.04006149619817734,
-0.015826767310500145,
-0.019075000658631325,
0.008750729262828827,
-0.0069421082735061646,
-0.02432892471551895,
-0.026696128770709038,
0.019532999023795128,
-0.005449945107102394,
0.0077773816883563995,
0.02263692021369934,
-0.002629394643008709,
0.038507334887981415,
0.0004793764092028141,
-0.03237802907824516,
-0.041707053780555725,
0.014523030258715153,
-0.024826860055327415,
-0.001559399999678135,
0.03298147767782211,
0.003656940069049597,
-0.02422064170241356,
0.010533665306866169,
-0.034046802669763565,
0.02392466366291046,
-0.024256998673081398,
0.038660772144794464,
-0.0030098215211182833,
0.02411549724638462,
0.04311627522110939,
-0.012741371989250183,
0.00764391478151083,
0.007679515518248081,
0.057281915098428726,
0.035639986395835876,
0.01753861829638481,
-0.0007764915935695171,
-0.030263442546129227,
-0.0017292434349656105,
0.015937378630042076,
0.023340551182627678,
-0.007996234111487865,
-0.002708965912461281,
-0.030242949724197388,
-0.0024743452668190002,
-0.00634404644370079,
-0.013195717707276344,
-0.02166176773607731,
-0.019952841103076935,
-0.016165103763341904,
0.0035782596096396446,
0.01951242983341217,
0.011629963293671608,
0.01947001740336418,
0.013360788114368916,
-0.00010518496856093407,
0.028469428420066833,
0.017061593011021614,
-0.0007793065160512924,
0.009278833866119385,
-0.01515892893075943,
-0.01898009143769741,
-0.008043886162340641,
-0.011699922382831573,
0.005776954349130392,
-0.016383636742830276,
0.012748586013913155,
-0.0003019459545612335,
-0.0005381717346608639,
0.0114366440102458,
0.006601752247661352,
-0.013872573152184486,
-0.02899775467813015,
0.009542310610413551,
0.0401671938598156,
0.020069491118192673,
-0.01901179365813732,
0.01284153200685978,
0.0267983078956604,
0.003909491002559662,
0.015547533519566059,
-0.0168084055185318,
-0.009964358061552048,
-0.009944077581167221,
-0.01639813929796219,
0.009929160587489605,
0.007519430015236139,
-0.054741404950618744,
-0.007025000639259815,
0.004757550545036793,
-0.01215972937643528,
-0.0005884815473109484,
0.017999853938817978,
-0.0035247227642685175,
-0.01661156676709652,
0.011843154206871986,
0.0016566405538469553,
0.04777234420180321,
0.016766861081123352,
-0.001907516736537218,
0.04880592226982117,
0.0175478458404541,
0.04032212495803833,
0.0009253781754523516,
-0.014507278800010681,
0.07117109000682831,
0.008417757228016853,
-0.006733479909598827,
-0.015336483716964722,
-0.03046833910048008,
-0.027701880782842636,
0.02192217856645584,
0.0076394351199269295,
-0.02424756810069084,
0.019773975014686584,
0.013753154315054417,
-0.003013026434928179,
0.025248318910598755,
0.002475196495652199,
-0.03345431387424469,
0.013276845216751099,
0.0008987386245280504,
-0.033831048756837845,
-0.005838447250425816,
0.029270630329847336,
0.005990481935441494,
-0.01575213298201561,
0.013604736886918545,
0.000053974566981196404,
0.0037792567163705826,
0.018723776564002037,
0.0338418185710907,
-0.012065339833498001,
-0.01114734262228012,
0.011145832017064095,
-0.01717057265341282,
-0.0036101751029491425,
-0.006473059765994549,
0.0004142685793340206,
0.004129244014620781,
-0.03247609734535217,
0.015355164185166359,
-0.010673618875443935,
0.01212253887206316,
0.01837877184152603,
0.0008908957242965698,
-0.01763066090643406,
0.04814416542649269,
0.015796635299921036,
0.025318365544080734,
-0.012175682932138443,
0.008140888065099716,
-0.009404930286109447,
-0.0036702430807054043,
-0.011469255201518536,
-0.009039893746376038,
-0.014542664401233196,
0.017721138894557953,
0.009783798828721046,
-0.0140765942633152,
-0.001492764800786972,
0.04546668753027916,
-0.023619648069143295,
0.0014847489073872566,
0.004295210354030132,
-0.012914538383483887,
-0.03245507925748825,
-0.025219518691301346,
-0.02945200353860855,
-0.012481318786740303,
-0.024492278695106506,
0.027980949729681015,
-0.005288982298225164,
0.05267256125807762,
-0.019154952839016914,
0.006655748002231121,
0.004587238188832998,
-0.020456712692975998,
0.006298172287642956,
-0.012035250663757324,
0.018884805962443352,
-0.02953392267227173,
0.01966722309589386,
0.02765241451561451,
-0.03325562924146652,
-0.032995209097862244,
0.040448736399412155,
0.01632745750248432,
-0.005490700248628855,
0.045255884528160095,
0.011309224180877209,
0.01110038161277771,
-0.07384997606277466,
-0.0441368892788887,
0.011227859184145927,
-0.018018852919340134,
0.003591657616198063,
0.0019730953499674797,
-0.023788247257471085,
0.01598346419632435,
-0.011027544736862183,
0.0019126745173707604,
0.01853492110967636,
0.04419180005788803,
-0.002367293229326606,
0.009425710886716843,
0.015184949152171612,
-0.030107911676168442,
-0.0005784151144325733,
0.008304805494844913,
-0.030942551791667938,
0.014461370185017586,
0.00550773274153471,
0.007687227800488472,
-0.047405533492565155,
0.004676308482885361,
-0.00411651935428381,
-0.07990296930074692,
-0.015850327908992767,
0.003169034607708454,
-0.026849860325455666,
-0.02924889139831066,
0.022101787850260735,
0.018058447167277336,
-0.02054077945649624,
-0.007797569036483765,
-0.020384667441248894,
0.027661237865686417,
0.05725613608956337,
-0.06344809383153915,
-0.014234647154808044,
0.0040426310151815414,
-0.006393326446413994,
0.01714801788330078,
0.022802365943789482,
-0.016029372811317444,
0.013198248110711575,
0.0028469515964388847,
0.02316085807979107,
-0.009240847080945969,
-0.0009605374652892351,
-0.012215414084494114,
-0.039994485676288605,
0.030606713145971298,
0.023728705942630768,
-0.010867096483707428,
-0.021405741572380066,
0.001579029019922018,
-0.005758736282587051,
-0.023991478607058525,
-0.005548868328332901,
0.005996920168399811,
-0.013732376508414745,
-0.0009509376250207424,
-0.003206399269402027,
-0.02389669418334961,
-0.02030831016600132,
-0.013014616444706917,
-0.010328969918191433,
-0.006213650573045015,
-0.00041279662400484085,
0.0043753148056566715,
0.011385001242160797,
0.009586948901414871,
-0.015542455017566681,
0.002538911998271942,
-0.022458799183368683,
0.00894097238779068,
0.02459544688463211,
-0.014759681187570095,
0.0069142840802669525,
-0.017154227942228317,
0.007710516918450594,
-0.005874838680028915,
-0.005856442265212536,
0.012493513524532318,
-0.0021031033247709274,
-0.016007274389266968,
-0.0018094927072525024,
-0.006374492309987545,
0.07008570432662964,
0.0036659142933785915,
-0.016618961468338966,
0.0010040791239589453,
-0.01772111840546131,
0.007863502949476242,
-0.031227076426148415,
0.01693735271692276,
0.011110607534646988,
-0.0018263367237523198,
0.01642688363790512,
-0.017604125663638115,
-0.027028251439332962,
0.018193699419498444,
0.0025146929547190666,
0.004230985417962074,
0.016613200306892395,
0.006540160160511732,
0.0008284319192171097,
-0.0006793024949729443,
0.031384967267513275,
0.01900465413928032,
-0.004270353354513645,
-0.027140222489833832,
0.0032916353084146976,
0.004222175106406212,
-0.00425147358328104,
-0.010035235434770584,
-0.013376008719205856,
0.025313803926110268,
-0.028366535902023315,
0.030063284561038017,
0.0013349463697522879,
-0.03776707127690315,
0.01754511334002018,
0.03342759609222412,
0.01873049885034561,
0.006053615361452103,
-0.030832983553409576,
0.005610828287899494,
0.010027039796113968,
-0.016958776861429214,
0.0029640276916325092,
0.0038104294799268246,
0.01441679522395134,
-0.0023509711027145386,
0.012617109343409538,
-0.011758076027035713,
-0.008962688967585564,
0.0037883296608924866,
0.02220151200890541,
-0.008421272039413452,
0.003961485810577869,
-0.02546180784702301,
0.007868459448218346,
-0.02300337515771389,
-0.018342189490795135,
0.01968587376177311,
0.016365397721529007,
0.004963284824043512,
-0.0000586601672694087,
-0.024956222623586655,
0.010745737701654434,
-0.039409294724464417,
0.061659689992666245,
-0.021865863353013992,
0.007516250014305115,
-0.025799261406064034,
0.02838175930082798,
0.02062523551285267,
0.019658852368593216,
-0.008815695531666279,
0.008219961076974869,
0.030985312536358833,
0.05276753380894661,
-0.020368214696645737,
-0.019972030073404312,
-0.004691815469413996,
-0.0004661800339818001,
0.01950809545814991,
-0.009685569442808628,
0.018448935821652412,
0.02273828163743019,
-0.012358536943793297,
0.007149482145905495,
0.007165343500673771,
0.036316610872745514,
0.014007268473505974,
-0.00012794393114745617,
0.014130289666354656,
0.04794924333691597,
0.00013167224824428558,
0.006865049246698618,
0.01304539479315281,
0.012419026345014572,
0.03440491110086441,
0.024271996691823006,
0.0035705966874957085,
0.014539789408445358,
0.01569991186261177,
0.013834268786013126,
-0.013007061555981636,
-0.01624837890267372,
0.017827656120061874,
0.003795674303546548,
-0.006511067971587181,
-0.02046169340610504,
-0.035405319184064865,
0.025774048641324043,
-0.0016301246359944344,
0.013832561671733856,
-0.00816349871456623,
0.03871321678161621,
0.006874562241137028,
-0.032612960785627365,
0.03573726862668991,
-0.013878446072340012,
0.020753487944602966,
-0.0072398423217237,
-0.01935075782239437,
-0.007417229935526848,
-0.0033451218623667955,
0.035303354263305664,
0.03339511528611183,
0.012264188379049301,
-0.01852036453783512,
-0.01780577003955841,
0.010706345550715923,
0.004999101627618074,
-0.02308751456439495,
0.033079180866479874,
0.029058335348963737,
-0.02362474426627159,
-0.008441928774118423,
0.014399876818060875,
-0.0004641131963580847,
-0.00736583024263382,
0.018690088763833046,
-0.026620829477906227,
0.03354520723223686,
0.003072981722652912,
-0.015605058521032333,
0.0006453805835917592,
-0.01710089109838009,
0.012271013110876083,
-0.015891186892986298,
-0.021141763776540756,
0.006629751995205879,
0.01630314439535141,
0.011336443945765495,
-0.015274228528141975,
0.009403856471180916,
0.014451511204242706,
-0.011038927361369133,
0.0008744278457015753,
0.006060519255697727,
0.021313080564141273,
0.005596294067800045,
-0.0020481576211750507,
0.007042423356324434,
0.0128835029900074,
-0.0012928394135087729,
0.012663356959819794,
0.00526256812736392,
0.004922379739582539,
-0.00997252855449915,
-0.027285035699605942,
-0.02038443088531494,
0.009223423898220062,
-0.023135393857955933,
0.0025552050210535526,
0.0143072959035635,
0.02167724445462227,
0.010412019677460194,
-0.02508222684264183,
-0.01199348084628582,
-0.017901543527841568,
-0.007163435686379671,
0.03868841007351875,
-0.01491315197199583,
-0.013098571449518204,
-0.015007293783128262,
-0.0020941575057804585,
-0.008191833272576332,
0.02006717026233673,
0.00814303383231163,
-0.007376772351562977,
-0.0066390130668878555,
-0.014451229944825172,
-0.02206069976091385,
-0.001845912542194128,
0.02540786936879158,
-0.016300365328788757,
0.012169629335403442,
-0.003982879221439362,
0.023388274013996124,
-0.001700658816844225,
-0.012617202475667,
0.011043761856853962,
0.03184504061937332,
0.007950539700686932,
-0.016974151134490967
] | [
0.1542304903268814,
0.024146201089024544,
-0.1234927698969841,
0.16565506160259247,
0.1970825046300888,
0.2572636008262634,
0.31228211522102356,
-0.08216268569231033,
-0.24326808750629425,
-0.22893235087394714,
-0.01254202239215374,
0.9068553447723389,
0.21382929384708405,
-0.3010561168193817,
-0.08258207887411118,
0.6514455080032349,
0.47380924224853516,
0.13644826412200928,
-0.4266909062862396,
-0.8546693921089172,
-0.010308507829904556,
-0.157342329621315,
0.7128122448921204,
-0.10241170227527618,
0.23197323083877563,
-0.2610977590084076,
0.28797903656959534,
0.14271442592144012,
0.3208189606666565,
-0.257628858089447,
-0.41395747661590576,
0.22383026778697968,
0.054664939641952515,
-0.12743398547172546,
-0.06842269748449326,
-0.21687830984592438,
0.1071493923664093,
-0.29814988374710083,
0.1372770071029663,
0.011472731828689575,
-0.16353344917297363,
-0.21202848851680756,
0.07489036023616791,
0.6319833397865295,
-0.03221042454242706,
-0.2568858861923218,
-1.3139126300811768,
0.43899425864219666,
0.04909338802099228,
-0.1518339365720749,
0.26259899139404297,
0.40490517020225525,
0.2349652349948883,
0.22445057332515717,
-0.19670730829238892,
0.42322683334350586,
-0.1354474276304245,
-0.3298485279083252,
0.152553990483284,
-0.5632850527763367,
0.044704511761665344,
0.18952149152755737,
-0.5553005337715149,
0.3827555179595947,
-0.23228608071804047,
0.8199741840362549,
0.28178536891937256,
-0.42108750343322754,
-0.09420843422412872,
-0.21332421898841858,
0.13702905178070068,
-0.06368686258792877,
-0.09488850831985474,
0.14571991562843323,
0.03848496451973915,
-0.02080504223704338,
0.16058312356472015,
-0.4211392104625702,
0.3188517987728119,
-0.43752214312553406,
0.18214285373687744,
0.1118582934141159,
0.11429459601640701,
0.1375974416732788,
0.015613149851560593,
0.24434779584407806,
0.05730528384447098,
0.38277727365493774,
-0.37974461913108826,
-0.17814454436302185,
-0.7088546752929688,
-0.5436922907829285,
0.2007226198911667,
0.7896069288253784,
0.06542224436998367,
0.5604509711265564,
0.0177888423204422,
-0.06164703890681267,
0.056370653212070465,
0.031145045533776283,
-0.42802587151527405,
0.23324425518512726,
-0.2580668032169342,
-0.23817528784275055,
-0.5419172048568726,
-0.19071424007415771,
-0.0023667553905397654,
-0.015699613839387894,
-0.9103121757507324,
0.3390478491783142,
-0.6877856254577637,
-0.2181263417005539,
-0.19794200360774994,
-0.08020859211683273,
0.14067299664020538,
-0.1658516377210617,
0.15494272112846375,
-0.38502421975135803,
-0.12838973104953766,
0.340580016374588,
-0.11701977998018265,
0.9987863302230835,
-0.1934402734041214,
0.3816654682159424,
0.012775351293385029,
-0.10401669144630432,
0.4634398818016052,
0.1107882633805275,
0.04939689114689827,
0.6937118172645569,
0.38445255160331726,
0.620354950428009,
-0.6999263167381287,
0.09260354936122894,
0.23767876625061035,
-0.03146907314658165,
0.24868667125701904,
0.4451344311237335,
0.07340837270021439,
0.3824692368507385,
-0.6323976516723633,
-0.3972877562046051,
0.05377422273159027,
0.16022121906280518,
0.27299976348876953,
-0.6773335933685303,
-0.05409536138176918,
-0.004188983701169491,
0.09674099832773209,
-0.22008299827575684,
0.09002923965454102,
-0.5178511738777161,
-0.6602180004119873,
-0.25096938014030457,
-0.269712895154953,
0.7733535766601562,
0.06861592084169388,
-0.48014384508132935,
-0.2864522933959961,
0.2572081983089447,
0.1827208697795868,
0.30571261048316956,
-0.45491355657577515,
-0.29757294058799744,
0.5979195833206177,
0.044143158942461014,
0.2679751515388489,
0.06865434348583221,
-0.002701819408684969,
-0.02800055779516697,
-0.498445063829422,
-0.2930241823196411,
-0.14484700560569763,
-0.7463095188140869,
-0.10647011548280716,
0.23959557712078094,
0.3911450207233429,
0.05963878333568573,
-0.08646547049283981,
-0.09623128175735474,
-0.5522710084915161,
0.21587876975536346,
-0.5290393233299255,
-0.5279249548912048,
0.40728339552879333,
-0.03036339208483696,
0.2309620976448059,
0.08094505220651627,
-0.005366316996514797,
-0.2979722023010254,
-0.1772133857011795,
-0.2736038565635681,
0.9807701706886292,
-0.6073136925697327,
1.637769341468811,
-0.5289584398269653,
0.06435351073741913,
0.9622005224227905,
0.16492290794849396,
0.22071972489356995,
-0.029362553730607033,
0.11022321879863739,
0.2979600727558136,
-0.3603329360485077,
-0.6937686800956726,
0.137566938996315,
0.28937220573425293,
-0.09443720430135727,
0.0012929574586451054,
0.13586750626564026,
0.5357387065887451,
0.3067587614059448,
-0.21341395378112793,
-0.23306593298912048,
0.3194284439086914,
0.023783285170793533,
0.09107399731874466,
-0.023755626752972603,
-0.211393803358078,
-0.06563136726617813,
-0.06404663622379303,
-0.5398555397987366,
0.6403827667236328,
0.4466194212436676,
-0.02761646918952465,
0.8623312711715698,
0.6378333568572998,
-0.01642078161239624,
0.6559581756591797,
-0.34250444173812866,
-0.027267297729849815,
-0.17062778770923615,
-0.03600481525063515,
-0.25023311376571655,
-0.2808700203895569,
-0.016247397288680077,
-0.0068049682304263115,
-0.022338641807436943,
0.046563342213630676,
0.28933751583099365,
0.08815222978591919,
0.19613707065582275,
-0.730974018573761,
-0.025218408554792404,
-0.1260889321565628,
-0.37254491448402405,
-0.2909330129623413,
0.26677316427230835,
-0.8085888624191284,
-0.35982170701026917,
-0.010711920447647572,
0.3910941481590271,
0.18871483206748962,
-0.2724876403808594,
0.2084520161151886,
-0.10629373043775558,
-0.40709272027015686,
-0.6139220595359802,
0.33504271507263184,
-0.37515977025032043,
0.09666924178600311,
0.11922299861907959,
0.19754305481910706,
0.24360503256320953,
0.15885598957538605,
-0.4387897253036499,
-0.6848522424697876,
-0.6021486520767212,
0.8835565447807312,
0.6138391494750977,
0.22692406177520752,
0.3150632083415985,
-0.7416098713874817,
0.1754264533519745,
0.2146937996149063,
-0.4658553898334503,
-0.021767588332295418,
0.5927626490592957,
-0.4375187158584595,
-0.23052559792995453,
0.03536979481577873,
0.37687286734580994,
0.9039532542228699,
0.12024693936109543,
-0.5472149848937988,
0.20783723890781403,
-0.5193836092948914,
0.02201812155544758,
-0.5928871035575867,
-0.2969145178794861,
-0.24467715620994568,
0.13154129683971405,
-0.028151914477348328,
-0.11481574177742004,
0.4265979826450348,
0.4037418067455292,
-0.19866813719272614,
0.09826221317052841,
0.43054819107055664,
-0.041818588972091675,
-0.11558022350072861,
0.4403987526893616,
-0.049673475325107574,
-0.3682019114494324,
-0.12502409517765045,
0.30143341422080994,
-0.3367476463317871,
0.07572419941425323,
-6.125758171081543,
0.1668432503938675,
-0.20095163583755493,
-0.21157018840312958,
-0.19352492690086365,
-0.1349366009235382,
0.6368244886398315,
-0.08626142144203186,
0.32560884952545166,
-0.06502628326416016,
0.12533973157405853,
0.4087088704109192,
0.22631993889808655,
0.3315696120262146,
-0.14579738676548004,
-0.044643234461545944,
0.11379777640104294,
-0.16068865358829498,
0.4292966425418854,
0.23494784533977509,
0.3570899963378906,
-0.22107002139091492,
-0.13789600133895874,
0.47452157735824585,
0.5224376320838928,
0.1356193870306015,
-0.6189271211624146,
0.3231430649757385,
0.03172443434596062,
-0.22943082451820374,
0.3393641710281372,
-0.44910940527915955,
-0.08221685886383057,
0.16541056334972382,
0.4595332145690918,
0.3066551089286804,
0.3912508487701416,
0.16802221536636353,
0.5909634232521057,
-0.18299010396003723,
-0.0105886897072196,
0.11955142766237259,
-0.1957206130027771,
-0.0440436452627182,
-0.01222006045281887,
0.15769325196743011,
-0.08222292363643646,
0.6318848729133606,
-0.08225161582231522,
0.9470887780189514,
-0.18870443105697632,
-0.05904529616236687,
0.16602402925491333,
0.5644474625587463,
0.6913121938705444,
0.11510811001062393,
-0.11610632389783859,
0.17639651894569397,
0.012612156569957733,
0.03631094843149185,
-0.10121502727270126,
-0.0012948202202096581,
-0.19286802411079407,
-0.7762012481689453,
0.07439354807138443,
0.2683669924736023,
-0.5586052536964417,
-0.3305667042732239,
0.04348551481962204,
0.048529502004384995,
-0.2860894799232483,
0.10089758038520813,
0.17413373291492462,
-0.7169213891029358,
0.30788394808769226,
-0.2896063029766083,
-0.1705235242843628,
0.2995522916316986,
-0.0907956212759018,
-0.32768484950065613,
-0.04582701623439789,
-0.2787093222141266,
0.14246554672718048,
-0.16709353029727936,
-0.0584259033203125,
0.19658014178276062,
-0.022077087312936783,
-0.09111279994249344,
-0.15911173820495605,
0.4628799855709076,
0.827914297580719,
-0.5118144154548645,
-0.2020025998353958,
0.36739397048950195,
0.3795248866081238,
0.7875562310218811,
0.6414434909820557,
0.1648389846086502,
0.4318065643310547,
-0.039449241012334824,
0.44724041223526,
-0.14864850044250488,
-0.17235198616981506,
-0.6526077389717102,
-0.2685268819332123,
0.13946428894996643,
-0.7058688402175903,
-0.24155378341674805,
0.8424375653266907,
-0.8367336988449097,
0.10814662277698517,
-0.3417949080467224,
-0.3029392957687378,
0.04584815725684166,
0.6075969934463501,
-0.27312585711479187,
0.13473671674728394,
-0.05028387904167175,
0.7915443778038025,
-0.31016483902931213,
0.3178212642669678,
0.11903980374336243,
-0.5763136148452759,
0.058879703283309937,
0.035296887159347534,
-0.267057329416275,
0.3854609727859497,
0.8149198293685913,
-0.8152721524238586,
-0.14582017064094543,
0.06366678327322006,
0.5328864455223083,
-0.4189324378967285,
0.07110525667667389,
0.11943962424993515,
-0.3227161467075348,
-0.5074246525764465,
0.044587381184101105,
0.40726161003112793,
0.2546244263648987,
-0.0044822534546256065,
-0.2492605298757553,
-0.22134247422218323,
-0.06112602353096008,
0.44031083583831787,
-0.05360298976302147,
-0.14358636736869812,
-0.33566322922706604,
-0.23104168474674225,
-0.014461897313594818,
0.011070705018937588,
0.10624602437019348,
0.4764457643032074,
-0.032531630247831345,
-0.31654590368270874,
-0.15606294572353363,
0.09956982731819153,
-0.13607361912727356,
-0.2983880341053009,
-0.17545859515666962,
0.5148565173149109,
0.23716244101524353,
-0.8291613459587097,
-0.06319030374288559,
0.2699471116065979,
-0.5607001781463623,
0.12762485444545746,
-0.9675934314727783,
0.20580904185771942,
0.31834518909454346,
-0.15943370759487152,
0.0354267954826355,
-0.20682713389396667,
-0.18006214499473572,
0.16420558094978333,
-0.4577931761741638,
-0.34370744228363037,
-0.08749174326658249,
-0.2323242872953415,
-0.1911744773387909,
0.2860499322414398,
-0.4215630292892456,
0.17949561774730682,
0.2224593162536621,
0.8770351409912109,
0.12145048379898071,
0.13062287867069244,
-0.30260321497917175,
-0.4735323488712311,
-0.31132474541664124,
0.15957927703857422,
0.19515492022037506,
0.6200118064880371,
-0.21472425758838654,
0.06284575909376144,
0.3550325334072113,
0.19270798563957214,
0.453888863325119,
0.07365041226148605,
-0.47997692227363586,
0.06595611572265625,
-0.17249764502048492,
-0.23808325827121735,
0.5238869786262512,
0.5213721394538879,
-0.21865859627723694,
-0.15822221338748932,
-0.1894960105419159,
-0.2509349286556244,
-0.16295434534549713,
-0.06287793070077896,
-0.5355531573295593,
0.3268144428730011,
0.41995754837989807,
-0.203817680478096,
0.06112566590309143,
0.2031797617673874,
-0.19316835701465607,
-0.7585499286651611,
0.3483627736568451,
0.4240725636482239,
-0.2947904169559479,
-0.31022587418556213,
0.05728226155042648,
-0.1787015199661255,
-0.27949318289756775,
0.6425506472587585,
-0.6004093885421753,
0.2784380316734314,
0.3359997272491455,
-0.47082316875457764,
-0.15258415043354034,
0.2814160883426666,
-0.14849834144115448,
-0.3155437111854553,
0.0510200634598732,
-0.44244569540023804,
0.02981184609234333,
-0.24143195152282715,
0.10321088880300522,
0.41693782806396484,
0.6705613136291504,
-0.3502405285835266,
-0.17993101477622986,
-0.11020497232675552,
0.4643305838108063,
0.1438620686531067,
-0.517234206199646,
0.008064614608883858,
0.24173951148986816,
0.489785760641098,
-0.27809807658195496,
0.3760588765144348,
0.03508646413683891,
0.28558143973350525,
-0.07408581674098969,
-0.34962159395217896,
-0.22747954726219177,
-0.049098845571279526,
0.6000027656555176,
-0.07080881297588348,
-0.4462374150753021,
-0.02215917594730854,
-0.24719810485839844,
0.1738867312669754,
0.0299895741045475,
-0.15822847187519073,
-0.5388068556785583,
0.3065008819103241,
-0.028326254338026047,
0.3318764567375183,
-0.1758929044008255,
0.4103172719478607,
0.41936278343200684,
-0.2865739166736603,
-0.13878045976161957,
-0.632647693157196,
-0.03983965888619423,
-0.019856898114085197,
0.11883535981178284,
-0.2992675304412842,
-0.37658631801605225,
0.05284508317708969,
-0.4752635955810547,
0.031169423833489418,
-0.5065997242927551,
0.3482144773006439,
-0.37711045145988464,
-0.17511461675167084,
-0.13490022718906403,
-0.14214834570884705,
-0.09116947650909424,
-0.6069644689559937,
-0.5823378562927246,
0.19814598560333252,
0.3094479441642761,
-0.021312188357114792,
0.33591505885124207,
0.12398340553045273,
0.03886192664504051,
-0.28694623708724976,
0.8470495343208313,
0.42569461464881897,
-0.5919306874275208,
0.19508400559425354,
0.30874934792518616,
-0.1140688955783844,
0.09524274617433548,
-0.3449688255786896,
-0.29561635851860046,
-0.04796072095632553,
0.13566376268863678,
0.03862985968589783,
0.11493967473506927,
-0.2076185941696167,
-0.24923278391361237,
-0.4200539290904999,
-0.24943862855434418,
0.30692800879478455,
0.3968659043312073,
0.3007219731807709,
0.77366703748703,
0.4115612804889679,
-0.47159847617149353,
-0.405029833316803,
0.47362852096557617,
-0.19220687448978424,
0.15529394149780273,
0.2559814155101776,
0.4589153528213501,
0.6517135500907898,
0.48084184527397156,
0.1560850590467453,
0.4706592261791229,
0.29300522804260254,
0.31165891885757446,
0.4051390290260315,
-0.759660542011261,
0.08172789961099625,
-0.2175997942686081,
1.1230907440185547,
0.12960420548915863,
0.030831191688776016,
-0.39844977855682373,
0.09085731208324432,
0.3176916837692261,
0.031982555985450745,
0.1481071263551712,
-0.23902364075183868,
0.40932315587997437,
0.17415115237236023,
-0.5651223063468933,
-0.13373936712741852,
-0.1670999974012375,
-0.35624226927757263,
-0.020050711929798126,
-0.19640058279037476,
0.02903272584080696,
-0.977402925491333,
0.10969836264848709,
-0.09020257741212845,
0.038423970341682434,
0.17900699377059937,
0.1301429718732834,
-0.24930569529533386,
-0.12272057682275772,
0.22943781316280365,
0.8068531155586243,
0.181555837392807,
-0.28279542922973633,
-0.2084907591342926,
-0.06944458186626434,
-0.38356372714042664,
-0.24641047418117523,
0.16846998035907745,
-0.7843051552772522,
-0.011850539594888687,
-0.13187716901302338,
0.08420741558074951,
0.5399110317230225,
-0.07914809137582779,
0.2747707664966583,
-0.12840168178081512,
-0.4314098060131073,
-0.19842489063739777,
-0.4315893352031708,
-0.14004066586494446,
-0.03457384184002876,
-0.01020336989313364,
-0.3830569088459015,
0.07154729962348938,
-0.507210373878479,
0.3219456076622009,
0.575674831867218,
-0.23162274062633514,
-0.43928298354148865,
-0.145988330245018,
0.4892767369747162,
0.4250739514827728,
0.28203609585762024,
-0.14885880053043365,
0.2048831433057785,
-0.2746453285217285,
0.4894982874393463,
-0.42674770951271057,
0.2890205383300781,
-0.6950684189796448,
-0.32819393277168274,
-0.5326639413833618,
-0.16646353900432587,
0.7410634160041809,
0.443472295999527,
-0.22795751690864563,
0.27879902720451355,
0.21656487882137299,
0.41149041056632996,
0.4570823311805725,
-0.04970039799809456,
-0.0009200738277286291,
-0.38175714015960693,
-0.2753206193447113,
-0.5200446248054504,
0.5545787215232849,
-0.029384266585111618,
-0.34765568375587463,
-0.1794785112142563,
0.06925264000892639,
0.3689175546169281,
-0.01709788665175438,
0.24531671404838562,
-0.4876534938812256,
-0.42002594470977783,
-0.6618856191635132,
0.6653016805648804,
-0.39703020453453064,
0.24549415707588196,
0.320180743932724,
-0.1565963327884674,
0.16163039207458496,
-0.1842571198940277,
-0.15066802501678467,
-0.4769652187824249,
0.41196906566619873,
0.3904028534889221,
-0.3434379994869232,
0.018225353211164474,
0.09487044811248779,
-0.48645317554473877,
-0.4984673261642456,
-0.03493773192167282,
-0.2183951586484909,
-0.537567138671875,
0.19121460616588593,
0.027785222977399826,
-0.11288009583950043,
-0.1611473560333252,
-0.03372578322887421,
-0.3899056315422058,
-0.37910982966423035,
-0.7215723991394043
] |
The toll-like receptor (TLR) and interleukin (IL)-1 family of receptors share several signaling components, including the most upstream adapter, MyD88. We previously reported the discovery of B cell adapter for phosphoinositide 3-kinase (BCAP) as a novel toll-IL-1 receptor homology domain-containing adapter that regulates inflammatory responses downstream of TLR signaling. Here we find that BCAP plays a critical role downstream of both IL-1 and IL-18 receptors to regulate T helper (Th) 17 and Th1 cell differentiation, respectively. Absence of T cell intrinsic BCAP did not alter development of naturally arising Th1 and Th17 lineages but led to defects in differentiation to pathogenic Th17 lineage cells. Consequently, mice that lack BCAP in T cells had reduced susceptibility to experimental autoimmune encephalomyelitis. More importantly, we found that BCAP is critical for IL-1R-induced phosphoinositide 3-kinase-Akt-mechanistic target of rapamycin (mTOR) activation, and minimal inhibition of mTOR completely abrogated IL-1β-induced differentiation of pathogenic Th17 cells, mimicking BCAP deficiency. This study establishes BCAP as a critical link between IL-1R and the metabolic status of activated T cells that ultimately regulates the differentiation of inflammatory Th17 cells. | [
0.010993864387273788,
-0.0014866798883304,
-0.0216156505048275,
0.007491110824048519,
0.017460897564888,
0.02268168330192566,
0.012888545170426369,
-0.0013173187617212534,
-0.016297832131385803,
0.0042119259014725685,
-0.019181981682777405,
0.009807145223021507,
-0.01038152165710926,
0.01757749170064926,
-0.02635471522808075,
0.030716966837644577,
-0.002138020470738411,
-0.0028449553065001965,
0.012073710560798645,
0.015480885282158852,
-0.0328480526804924,
0.011609446257352829,
0.011530201882123947,
-0.008705408312380314,
0.023581866174936295,
-0.004919541068375111,
0.022864043712615967,
0.012040330097079277,
-0.017761381343007088,
-0.0006187558174133301,
0.023490848019719124,
-0.012122503481805325,
0.02727511152625084,
0.028035631403326988,
-0.0016361076850444078,
0.005071057938039303,
-0.015876874327659607,
0.014024240896105766,
0.023074429482221603,
-0.004614931531250477,
-0.03785069286823273,
-0.011008305475115776,
-0.003457262646406889,
-0.01789775677025318,
-0.008447722531855106,
-0.026172954589128494,
-0.00581227894872427,
0.002187602687627077,
-0.011630453169345856,
0.003407445503398776,
-0.007570096757262945,
-0.010607201606035233,
-0.016585221514105797,
0.039289440959692,
-0.007487555034458637,
0.040583811700344086,
0.02057557925581932,
0.0002908199094235897,
-0.0026981914415955544,
0.011585275642573833,
-0.014731867238879204,
-0.03646855428814888,
-0.0015454739332199097,
-0.030531711876392365,
0.00803076196461916,
-0.06626497209072113,
0.00920924637466669,
-0.011924201622605324,
0.0031763846054673195,
-0.012287130579352379,
-0.03967788815498352,
0.013747255317866802,
-0.024412959814071655,
-0.039864689111709595,
-0.01226549781858921,
-0.003865085542201996,
-0.017829082906246185,
0.02423657849431038,
-0.005968981422483921,
0.028079766780138016,
0.0042685335502028465,
-0.015449494123458862,
0.03266442194581032,
0.01963777095079422,
-0.0004211233463138342,
0.006010827608406544,
-0.015115182846784592,
-0.011496871709823608,
-0.03342420235276222,
-0.029767386615276337,
-0.02910204418003559,
-0.014861613512039185,
0.011851871386170387,
0.004737507551908493,
-0.0008646892383694649,
0.0019127221312373877,
-0.030269749462604523,
0.00788390077650547,
0.011780660599470139,
0.013839801773428917,
-0.017262505367398262,
0.010646791197359562,
0.013712109997868538,
0.005487530492246151,
0.008281094953417778,
0.009403247386217117,
-0.0015381108969449997,
0.006925259716808796,
-0.0006287135183811188,
0.015725286677479744,
0.00564733287319541,
0.02665954828262329,
-0.008418751880526543,
0.004643566906452179,
-0.019942164421081543,
0.007601164747029543,
-0.039034996181726456,
-0.010656293481588364,
0.014811774715781212,
-0.012609390541911125,
-0.02081758715212345,
-0.0010139686055481434,
-0.00006509386003017426,
0.017498701810836792,
0.0039831483736634254,
0.021486150100827217,
0.011079340241849422,
0.0370696559548378,
-0.012720618396997452,
0.015546435490250587,
-0.011291179805994034,
0.02210729941725731,
0.007088889833539724,
-0.007380013354122639,
0.012062475085258484,
0.004821925889700651,
-0.00812294241040945,
0.0032177846878767014,
-0.012058170512318611,
-0.003175391349941492,
-0.004664895590394735,
0.011952677741646767,
0.015313059091567993,
0.019161097705364227,
0.011611160822212696,
0.004057581536471844,
0.02276352047920227,
-0.012497438117861748,
0.02632501721382141,
-0.0011528925970196724,
0.0002699964679777622,
0.009347466751933098,
-0.010876059532165527,
-0.02721034362912178,
0.046725738793611526,
0.04695913940668106,
-0.010955759324133396,
-0.0291526410728693,
0.00008317222818732262,
0.0034355614334344864,
0.034994952380657196,
-0.021204238757491112,
0.041463445872068405,
0.011095130816102028,
0.010468058288097382,
0.018277671188116074,
0.019181590527296066,
-0.02728944644331932,
0.0020786605309695005,
0.005178320221602917,
-0.015607167035341263,
0.039859283715486526,
-0.03805870562791824,
0.007365042343735695,
-0.013963595032691956,
-0.006521644536405802,
-0.003435407765209675,
0.008611801080405712,
-0.006494465284049511,
0.06591925024986267,
0.038878656923770905,
-0.028778448700904846,
0.05649055540561676,
-0.028301989659667015,
-0.00381906284019351,
-0.01227259449660778,
0.030184198170900345,
0.002542150439694524,
-0.010322113521397114,
-0.0030354007612913847,
-0.016366833820939064,
-0.018749168142676353,
-0.04513737931847572,
0.007668775971978903,
0.017867878079414368,
0.001379049033857882,
0.024429110810160637,
0.008284574374556541,
0.006237601395696402,
0.03814450278878212,
-0.0006216829642653465,
-0.03840154409408569,
0.01819295808672905,
-0.030672576278448105,
-0.0231238454580307,
0.004991163499653339,
-0.0011084778234362602,
-0.012447584420442581,
-0.015206786803901196,
0.012639484368264675,
0.023724265396595,
-0.029815878719091415,
-0.0020744050852954388,
-0.004789699800312519,
0.001987377181649208,
0.022637665271759033,
-0.026029132306575775,
0.002511654980480671,
0.02268378809094429,
-0.01902049593627453,
-0.0045636664144694805,
-0.0028977205511182547,
0.003971434198319912,
-0.015100730583071709,
0.02070019021630287,
-0.0051864138804376125,
-0.008699825033545494,
0.01560649462044239,
-0.010439292527735233,
0.003450504969805479,
-0.007309997454285622,
-0.013547668233513832,
-0.01859506033360958,
0.009531490504741669,
0.019078992307186127,
-0.049309417605400085,
0.017780376598238945,
0.004352905787527561,
0.013583654537796974,
-0.01272553950548172,
-0.004258096218109131,
-0.017849229276180267,
0.014259375631809235,
-0.030405603349208832,
-0.040965937077999115,
0.00826592929661274,
0.00863666646182537,
0.020545464009046555,
-0.015283402986824512,
-0.020271988585591316,
0.009245235472917557,
-0.017395850270986557,
-0.008222002536058426,
-0.0317130908370018,
0.010751317255198956,
-0.032284099608659744,
0.00041243486339226365,
-0.021251097321510315,
0.026368463411927223,
0.02105095237493515,
0.0023366068489849567,
0.009918959811329842,
0.010058131068944931,
0.0016483953222632408,
-0.003767247311770916,
-0.007698219735175371,
-0.017139211297035217,
-0.0025475788861513138,
-0.002450235653668642,
0.016284365206956863,
0.013899024575948715,
-0.00605314876884222,
-0.00024396233493462205,
-0.08091563731431961,
-0.01914959028363228,
-0.003288793144747615,
0.007349140010774136,
0.008103669621050358,
-0.02785579115152359,
-0.01714322157204151,
0.01000549178570509,
-0.007459140382707119,
0.018059056252241135,
-0.010888852179050446,
0.014062456786632538,
-0.010832751169800758,
-0.025309378281235695,
0.03240778297185898,
-0.010875050909817219,
0.01845410279929638,
-0.02016587182879448,
-0.01837615668773651,
-0.06421658396720886,
0.01322847604751587,
-0.005609527230262756,
0.007498608436435461,
0.001096774241887033,
0.0004089474678039551,
-0.01750819757580757,
0.012626361101865768,
0.0014026418793946505,
-0.021992553025484085,
-0.0011696370784193277,
-0.022510435432195663,
0.014951581135392189,
0.017381949350237846,
0.024109315127134323,
0.014877412468194962,
0.011639684438705444,
-0.004396569449454546,
-0.024484435096383095,
-0.014633888378739357,
-0.0008730343542993069,
-0.003994429484009743,
0.013767242431640625,
0.0002556317485868931,
0.016566181555390358,
0.0069391862489283085,
0.018995516002178192,
-0.029571354389190674,
-0.013483687303960323,
0.015333916991949081,
-0.016919031739234924,
0.01648334600031376,
0.007232442032545805,
-0.019240688532590866,
0.026350662112236023,
0.00016666390001773834,
-0.017590204253792763,
-0.013819924555718899,
-0.00820728950202465,
-0.005133756436407566,
-0.006987941451370716,
0.006839761044830084,
-0.005363762378692627,
0.034303806722164154,
0.010073008947074413,
0.025209715589880943,
0.002172130160033703,
0.009717384353280067,
-0.01256517693400383,
-0.014703898690640926,
0.003005647799000144,
0.0299393180757761,
-0.012256837449967861,
-0.022580869495868683,
-0.0006177009781822562,
-0.014509396627545357,
-0.013183941133320332,
-0.01549580693244934,
0.00015954533591866493,
0.006467652041465044,
-0.004845402203500271,
0.00205492926761508,
0.005398355424404144,
-0.034289054572582245,
-0.024559563025832176,
-0.015493982471525669,
-0.009982125833630562,
0.004681183025240898,
0.01735263131558895,
0.008732734248042107,
-0.021340150386095047,
0.048874691128730774,
0.011960301548242569,
0.01915951445698738,
0.010441092774271965,
-0.005513583309948444,
-0.013286388479173183,
-0.021390050649642944,
0.015211142599582672,
-0.011140326038002968,
0.009838037192821503,
-0.02099764719605446,
0.019152164459228516,
-0.005742937326431274,
-0.005284071899950504,
-0.016361648216843605,
0.011953658424317837,
0.00819857232272625,
0.007332834415137768,
-0.008832038380205631,
-0.0034089703112840652,
0.0035757648292928934,
-0.00511315930634737,
-0.00648178206756711,
0.04405590146780014,
0.014817604795098305,
0.02051693946123123,
-0.02046668715775013,
-0.037793755531311035,
0.07135561108589172,
-0.009577474556863308,
0.003833430353552103,
-0.019659996032714844,
0.045353081077337265,
-0.019204722717404366,
-0.010100474581122398,
0.020102716982364655,
-0.00562116876244545,
0.00850530993193388,
0.014184389263391495,
0.017102975398302078,
-0.006842314265668392,
0.013539171777665615,
-0.01246695313602686,
0.025662893429398537,
-0.003223065286874771,
0.01542411744594574,
0.05289982259273529,
0.012112721800804138,
0.007770161610096693,
-0.02908303216099739,
0.022486988455057144,
0.00040292716585099697,
-0.005299587268382311,
-0.04043849557638168,
0.01767212152481079,
-0.015731660649180412,
-0.02800087258219719,
0.008845710195600986,
-0.012952112592756748,
-0.009803817607462406,
-0.012446867302060127,
0.011799555271863937,
0.016678735613822937,
0.01494515873491764,
0.04756435751914978,
-0.013781209476292133,
0.015174157917499542,
0.005616558250039816,
-0.01272976491600275,
-0.018245847895741463,
-0.007605860009789467,
-0.0012229961575940251,
-0.006557876244187355,
-0.0018721173983067274,
-0.03648634999990463,
-0.005545491352677345,
-0.00176461529918015,
-0.009924288839101791,
-0.0019780455622822046,
0.02420804277062416,
0.014811614528298378,
-0.021324070170521736,
-0.00469435378909111,
0.0012458013370633125,
0.031146153807640076,
0.0016202207189053297,
-0.0032734517008066177,
-0.018981998786330223,
-0.01908855512738228,
0.023303139954805374,
0.001501955557614565,
-0.01183492224663496,
0.00885505136102438,
-0.022404063493013382,
-0.013437439687550068,
-0.007420589681714773,
-0.006186259910464287,
-0.019416218623518944,
0.005323009565472603,
-0.0045289089903235435,
0.01917431503534317,
0.01751207932829857,
-0.033864397555589676,
0.008245432749390602,
-0.011053408496081829,
-0.01651609316468239,
0.012465248815715313,
0.016327865421772003,
-0.015112025663256645,
0.032578255981206894,
0.00389144872315228,
-0.044768042862415314,
0.009601709432899952,
0.005728230811655521,
0.006508450489491224,
-0.07411284744739532,
-0.018743615597486496,
-0.009263971820473671,
-0.0061127603985369205,
0.0010743504390120506,
0.025641757994890213,
-0.005701667629182339,
-0.02298262156546116,
0.007010303437709808,
-0.016760412603616714,
-0.020965969190001488,
0.014940847642719746,
-0.014013385400176048,
0.023623822256922722,
0.011398875154554844,
0.0013529255520552397,
-0.02014157362282276,
0.0003223177045583725,
-0.02497567981481552,
0.00400267168879509,
0.022536130622029305,
-0.005844199098646641,
-0.004737331531941891,
0.019825618714094162,
-0.00612435769289732,
-0.08021564781665802,
0.00907928217202425,
-0.004887549672275782,
0.0040880851447582245,
0.017319582402706146,
-0.04331927001476288,
0.004722828045487404,
-0.01092613860964775,
-0.05350648984313011,
-0.017825506627559662,
0.009099530056118965,
0.009059883654117584,
-0.03225409984588623,
-0.012442419305443764,
-0.005226829554885626,
-0.010822216048836708,
0.006359809078276157,
-0.02507854625582695,
-0.010750370100140572,
-0.01690586656332016,
0.008191237226128578,
0.009960430674254894,
-0.01151588000357151,
-0.011554298922419548,
-0.005498729646205902,
-0.04440693557262421,
-0.002184751909226179,
0.012639445252716541,
0.009246675297617912,
-0.03147393465042114,
-0.002872913610190153,
-0.020856531336903572,
-0.020635265856981277,
-0.018743351101875305,
-0.009620575234293938,
-0.016801228746771812,
0.0058226147666573524,
-0.01629769429564476,
0.01623087376356125,
0.001675337553024292,
-0.00885075144469738,
0.027921881526708603,
-0.012799725867807865,
0.02751489356160164,
-0.01091759093105793,
-0.031096577644348145,
0.009705040603876114,
-0.00545182591304183,
0.008745033293962479,
0.018342003226280212,
0.012584470212459564,
-0.012991644442081451,
-0.004448790568858385,
-0.0023684685584157705,
0.049334198236465454,
0.004357938189059496,
-0.008380675688385963,
-0.016591064631938934,
-0.04355362057685852,
0.00660266587510705,
0.0008159042336046696,
0.005891581065952778,
0.03127807751297951,
0.07111726701259613,
-0.015113221481442451,
0.02962493523955345,
-0.021775631234049797,
-0.0018340868409723043,
0.0113679189234972,
-0.007862752303481102,
0.004435772076249123,
-0.03535584360361099,
-0.02886176109313965,
-0.011696459725499153,
-0.023273680359125137,
0.036321744322776794,
0.012036914005875587,
-0.0041806939989328384,
0.009240824729204178,
0.0023780399933457375,
-0.01918593980371952,
0.001946647884324193,
0.0029726126231253147,
0.04124079644680023,
0.011564214713871479,
-0.008195311762392521,
0.00048008793964982033,
0.012018507346510887,
0.010262704454362392,
0.018857302144169807,
0.0008448755834251642,
-0.027454396709799767,
0.020815521478652954,
0.002042369684204459,
0.010315029881894588,
0.004979406017810106,
-0.015293462201952934,
0.02506949007511139,
0.013296355493366718,
-0.022072454914450645,
0.018521277233958244,
0.005689768586307764,
-0.0050126020796597,
-0.035080477595329285,
0.018867144361138344,
-0.005590015556663275,
-0.015083333477377892,
0.007326060906052589,
0.0022607664577662945,
0.014572792686522007,
0.01571761444211006,
-0.017740542069077492,
0.016673807054758072,
0.017756907269358635,
-0.009114648215472698,
0.012836741283535957,
-0.01264162641018629,
-0.0082014761865139,
0.02861109748482704,
-0.008615050464868546,
0.00922086089849472,
-0.022320784628391266,
-0.021569574251770973,
0.010545214638113976,
-0.016637075692415237,
0.015143285505473614,
-0.01163085550069809,
0.0015538990264758468,
-0.01843463070690632,
-0.006019222550094128,
-0.03423848748207092,
-0.028098590672016144,
0.018638692796230316,
-0.011100471951067448,
0.004935937933623791,
0.014369416981935501,
-0.0007840951438993216,
0.013915461488068104,
0.024837814271450043,
0.030318239703774452,
0.012035846710205078,
0.012702847830951214,
-0.0032435066532343626,
-0.015781965106725693,
0.03738902509212494,
0.009293711744248867,
0.03331369906663895,
-0.012512766756117344,
0.006869328208267689,
0.005742589943110943,
0.011901956982910633,
-0.000503599876537919,
0.011732997372746468,
-0.0052370610646903515,
0.007701351307332516,
0.0028288993053138256,
-0.007700188085436821,
0.00815615989267826,
0.034508854150772095,
0.039943017065525055,
0.010953201912343502,
-0.012823385186493397,
0.007581216283142567,
0.003143749199807644,
-0.013038160279393196,
0.0014658477157354355,
0.020537517964839935,
0.0021981799509376287,
-0.010379716753959656,
-0.034222736954689026,
0.0065573398023843765,
-0.0013193115592002869,
0.02591611072421074,
-0.015454481355845928,
0.012052379548549652,
0.015141095034778118,
0.0020957267843186855,
-0.0031169583089649677,
0.02104334905743599,
-0.008407537825405598,
0.014211857691407204,
0.0010612113401293755,
-0.015550040639936924,
0.03556273877620697,
0.02288740687072277,
-0.02655334770679474,
0.008557697758078575,
-0.001624669530428946,
0.007681835908442736,
-0.01818731799721718,
0.02757754921913147,
0.012722350656986237,
-0.004031287971884012,
0.016462787985801697,
-0.014780604280531406,
-0.0003411457873880863,
-0.009514525532722473,
-0.019530709832906723,
0.02095283940434456,
-0.007547840941697359,
-0.00018630435806699097,
0.03417643532156944,
0.016562169417738914,
-0.017659762874245644,
-0.02176796831190586,
-0.007130873389542103,
-0.010717425495386124,
0.009226511232554913,
-0.02619127929210663,
-0.019993428140878677,
-0.010205065831542015,
-0.00017650739755481482,
0.011252899654209614,
0.008219124749302864,
-0.0022325182799249887,
-0.012975508347153664,
-0.00791007000952959,
0.00006049778312444687,
0.021969111636281013,
0.015809306874871254,
0.02544543333351612,
-0.01647506281733513,
-0.039542242884635925,
-0.002599333180114627,
0.003935664892196655,
-0.006370277144014835,
-0.02303287759423256,
0.0025598453357815742,
-0.03601595386862755,
0.03847252205014229,
0.014387238770723343,
0.01640447787940502,
-0.028490569442510605,
0.008983851410448551,
-0.04755709320306778,
0.0037439758889377117,
-0.004770122468471527,
0.01479339599609375,
-0.0037613767199218273,
0.0011456392239779234,
-0.001539756078273058,
0.014254715293645859,
-0.004133515991270542,
-0.0011968715116381645,
-0.036874063313007355,
-0.004619808867573738,
-0.016214825212955475,
-0.00616031838580966,
-0.011760166846215725,
-0.006617183797061443,
-0.004280801396816969,
0.007185044232755899,
-0.013965809717774391,
-0.014121629297733307,
-0.03719902038574219,
-0.008368954993784428,
-0.0010104309767484665,
0.008811216801404953,
-0.009541815146803856,
-0.004643626511096954,
0.005888017825782299,
0.00017882324755191803,
-0.0071674371138215065,
-0.00897697638720274,
0.0048588034696877
] | [
-0.12473910301923752,
0.30710935592651367,
0.6576136946678162,
0.07478514313697815,
-0.46938568353652954,
-0.021205579861998558,
0.12059321999549866,
-0.49602460861206055,
-0.14344742894172668,
-0.342764288187027,
0.35637176036834717,
0.33856791257858276,
-0.6264101266860962,
0.17686690390110016,
0.49318647384643555,
0.48413023352622986,
0.2552908957004547,
0.3185649514198303,
-0.4869999587535858,
-0.8637418150901794,
0.16076762974262238,
-0.23140546679496765,
0.6436685919761658,
-0.1651008129119873,
0.36856427788734436,
0.5067638158798218,
0.2782149612903595,
0.12973231077194214,
0.5467971563339233,
-0.2732461094856262,
0.04944435507059097,
0.523043692111969,
-0.575674295425415,
0.1616574078798294,
-0.49176275730133057,
0.0603473000228405,
-0.23629489541053772,
-0.04620477184653282,
0.15272045135498047,
-0.1922188103199005,
0.03171385079622269,
-0.5929499268531799,
-0.575167715549469,
0.6902219653129578,
-0.10929679125547409,
-0.37265658378601074,
-1.1671699285507202,
0.6113057136535645,
-0.11497819423675537,
-0.2530381679534912,
-0.06715797632932663,
0.4834936857223511,
0.32835960388183594,
0.08290337026119232,
0.686339259147644,
0.07383213937282562,
-0.6743786334991455,
-0.26196619868278503,
0.46432292461395264,
-0.6684879660606384,
-0.16470494866371155,
0.3039129972457886,
-0.08747982233762741,
0.03718067333102226,
-0.15083204209804535,
1.0467079877853394,
-0.09642266482114792,
-0.4687075614929199,
-0.3118240237236023,
-0.013788505457341671,
-0.018533235415816307,
-0.541900634765625,
-0.4270448684692383,
0.43877124786376953,
0.08691813051700592,
-0.07824373245239258,
-0.3922664225101471,
-0.34802258014678955,
0.17384560406208038,
0.2531670331954956,
0.32936927676200867,
0.5553617477416992,
0.4985904097557068,
-0.022587338462471962,
0.6888319253921509,
-0.004356335382908583,
-0.037631116807460785,
0.21960154175758362,
-0.5600499510765076,
-0.020233910530805588,
-0.5000811815261841,
-0.14893466234207153,
0.5238995552062988,
0.41306886076927185,
0.29231852293014526,
0.3667556345462799,
0.0615234412252903,
0.05740495026111603,
-0.1544676274061203,
0.27052968740463257,
0.06567094475030899,
-0.06353018432855606,
-0.06846906244754791,
-0.8103837966918945,
-0.3756060302257538,
-0.35038235783576965,
-0.200720876455307,
-0.6956881284713745,
-0.5744138360023499,
0.1300669014453888,
-0.9971896409988403,
-0.04010239988565445,
-0.25382712483406067,
-0.16135308146476746,
0.4632912576198578,
-0.034228596836328506,
0.31934085488319397,
-0.6721640825271606,
0.38645026087760925,
0.07444994151592255,
-0.2830702066421509,
1.251603126525879,
-0.16979680955410004,
0.4996263086795807,
0.053632646799087524,
0.10738296806812286,
-0.03132135048508644,
-0.3833327293395996,
-0.2810477316379547,
0.6249500513076782,
0.2708323895931244,
0.9536010026931763,
-0.319772869348526,
0.000992577406577766,
-0.1411343514919281,
-0.27231308817863464,
0.01251946110278368,
0.18201257288455963,
-0.12476024031639099,
-0.1629471629858017,
-0.5022619366645813,
-0.5967366695404053,
-0.5095677375793457,
-0.29372310638427734,
-0.3623243570327759,
-0.36160117387771606,
-0.45040252804756165,
0.046077679842710495,
0.3359333276748657,
-0.17934688925743103,
-0.150727778673172,
-0.40739694237709045,
-0.4940495491027832,
-0.003896638285368681,
-0.17607055604457855,
0.20355720818042755,
0.3555828630924225,
-0.17145608365535736,
0.62093585729599,
0.048008713871240616,
0.21216242015361786,
-0.3709430694580078,
-0.5273414850234985,
-0.31820276379585266,
0.5690461993217468,
-0.09177494049072266,
0.04203816503286362,
0.22824236750602722,
0.0701393112540245,
-0.05240660533308983,
-0.5466550588607788,
-0.25789281725883484,
-0.02775820530951023,
-0.5212579965591431,
-0.296701043844223,
-0.6652048826217651,
0.3860478103160858,
-0.12489081919193268,
-0.03296659514307976,
-0.0885007306933403,
-0.7398893237113953,
-0.4154118597507477,
-0.7011758089065552,
-0.725078284740448,
0.3358634412288666,
0.5477601289749146,
0.3003491759300232,
-0.06964796036481857,
0.24305474758148193,
-0.22588945925235748,
0.14325179159641266,
-0.0727526992559433,
0.4261375367641449,
-0.28489646315574646,
1.4039655923843384,
-0.5571569204330444,
-0.259329229593277,
1.4344006776809692,
0.6051167845726013,
0.21910184621810913,
-0.03926938399672508,
-0.19811294972896576,
0.49714505672454834,
-0.17326517403125763,
-0.5982407927513123,
0.18885846436023712,
-0.4033766984939575,
0.1049313023686409,
-0.03782343491911888,
-0.014266476966440678,
0.5009183883666992,
-0.0998528003692627,
-0.33208587765693665,
-0.12098988890647888,
0.1298203021287918,
-0.5231835842132568,
0.209469273686409,
0.022025877609848976,
-0.8225994110107422,
0.2136349081993103,
0.3989841043949127,
-0.7744748592376709,
0.5262805819511414,
1.133967399597168,
-0.5414579510688782,
0.733211874961853,
0.3491804897785187,
0.27167242765426636,
0.68895024061203,
-0.2421785593032837,
0.5694077610969543,
-0.5307877659797668,
0.10093715041875839,
-0.4405075013637543,
0.22487221658229828,
-0.0678417831659317,
0.14011816680431366,
-0.1897730529308319,
-0.29485073685646057,
-0.1286727339029312,
-0.16128791868686676,
0.9730236530303955,
-0.5905469655990601,
-0.14411859214305878,
0.159682035446167,
-0.6425477266311646,
-0.35506418347358704,
0.21312111616134644,
-0.996129035949707,
0.15748532116413116,
0.09883791953325272,
0.04960932210087776,
0.2379850596189499,
-0.4616875648498535,
0.20337973535060883,
0.3665234446525574,
-0.23418167233467102,
-0.21727530658245087,
-0.10677521675825119,
-0.49268510937690735,
-0.057636529207229614,
-0.10421747714281082,
0.1667095422744751,
0.08690990507602692,
0.0630268082022667,
-0.5271658301353455,
-0.19485962390899658,
-0.18111740052700043,
0.8446747064590454,
0.7450527548789978,
0.9156575202941895,
-0.22387202084064484,
-0.6570907831192017,
0.034388747066259384,
0.34682217240333557,
-0.37614017724990845,
0.06136046722531319,
0.8122141361236572,
-0.25025734305381775,
-0.5161303281784058,
-0.24741482734680176,
-0.06927452236413956,
0.9589357376098633,
0.022893914952874184,
-0.6048209071159363,
-0.21916478872299194,
-0.2623664438724518,
-0.41274651885032654,
-0.6769537329673767,
-0.3174053728580475,
0.2137044370174408,
0.41603705286979675,
-0.0852038785815239,
0.2841624617576599,
0.17214475572109222,
0.34501221776008606,
0.06264399737119675,
0.6411750316619873,
0.8362483382225037,
-0.21170081198215485,
-0.2708181142807007,
0.2541337311267853,
-0.3225817084312439,
-0.042824387550354004,
0.10444249212741852,
-0.0015006052562966943,
-0.49998795986175537,
0.06076379120349884,
-5.650834083557129,
0.24060893058776855,
-0.10194757580757141,
-0.44945669174194336,
0.03049973025918007,
0.08651255071163177,
1.2125284671783447,
-0.0042089722119271755,
0.16402846574783325,
0.4460488259792328,
0.43190741539001465,
0.4336899220943451,
-0.12476217746734619,
-0.030771486461162567,
-0.10867831110954285,
0.30561208724975586,
-0.25369083881378174,
0.1902560293674469,
0.7037279605865479,
-0.11995915323495865,
0.3327156901359558,
-0.08009658008813858,
-0.25467389822006226,
0.39240899682044983,
0.08159156888723373,
-0.5478870868682861,
-1.3679723739624023,
-0.03915255144238472,
0.14177463948726654,
-0.26266956329345703,
0.25837576389312744,
-0.15617139637470245,
-0.20311091840267181,
-0.1892317682504654,
0.4576970040798187,
0.2182275354862213,
0.3156547248363495,
0.1714974194765091,
-0.20120809972286224,
-0.5997162461280823,
0.2512092888355255,
0.3775414228439331,
0.09945554286241531,
-0.26614293456077576,
0.21662336587905884,
-0.2926514446735382,
-0.31596317887306213,
0.17634588479995728,
-0.5927557945251465,
0.5647952556610107,
-0.3091788589954376,
-0.3042965829372406,
0.013177323155105114,
0.7716164588928223,
0.846079409122467,
-0.04365204647183418,
-0.20721039175987244,
-0.215103879570961,
-0.6033080816268921,
0.399980366230011,
-0.2391279935836792,
-0.12640585005283356,
-0.46625444293022156,
-0.7974304556846619,
0.20121988654136658,
0.29408326745033264,
-0.8114639520645142,
-0.7368532419204712,
0.3967854976654053,
-0.4161061644554138,
-0.6143447160720825,
-0.07360126078128815,
-0.15106764435768127,
-0.6140974164009094,
0.8012406826019287,
-0.2530665099620819,
0.3251458406448364,
0.4990065097808838,
-0.3588624596595764,
-0.33318057656288147,
-0.0845927894115448,
-0.166940376162529,
-0.1404324471950531,
0.2698584794998169,
0.1309354603290558,
0.023194748908281326,
-0.2709313929080963,
-0.28964176774024963,
-0.331824392080307,
0.27110418677330017,
0.053647227585315704,
-0.3695436418056488,
0.09646176546812057,
0.48043155670166016,
-0.36592933535575867,
0.05650811269879341,
0.11636973172426224,
0.7173341512680054,
0.6829974055290222,
-0.06535560637712479,
0.9970945119857788,
-0.09733428061008453,
-0.6648929715156555,
-0.5822286605834961,
-0.05845912918448448,
0.3281874656677246,
0.2958943545818329,
0.18629005551338196,
0.9803882837295532,
-0.5679170489311218,
-0.050862498581409454,
-0.19850334525108337,
-0.5014855861663818,
0.01321225706487894,
0.6785901188850403,
-0.40360212326049805,
-0.4380108416080475,
-0.18635284900665283,
0.3204090893268585,
-0.09231454133987427,
-0.03627544641494751,
0.5005048513412476,
-0.3881763219833374,
0.5069276690483093,
-0.06635896116495132,
-0.14549994468688965,
-0.16315896809101105,
0.31217604875564575,
-0.8033510446548462,
-0.2824357748031616,
0.33363255858421326,
0.2633357644081116,
-0.1434192657470703,
-0.09600227326154709,
0.011330525390803814,
-0.43969962000846863,
-0.25345903635025024,
0.5024346113204956,
0.9629213809967041,
-0.21429312229156494,
0.2149716019630432,
-0.45216888189315796,
-0.42460307478904724,
0.13889263570308685,
0.19640924036502838,
-0.005899430252611637,
0.1768500953912735,
0.5673363208770752,
-0.8411818742752075,
-0.03976628556847572,
-0.010085182264447212,
-0.32835549116134644,
-0.031669627875089645,
0.17804650962352753,
0.044588081538677216,
0.4276367723941803,
0.8649062514305115,
0.44649675488471985,
0.30071574449539185,
-0.6814668774604797,
0.2133469581604004,
0.0872499942779541,
-0.2445349395275116,
0.47022947669029236,
-0.013690253719687462,
-0.41988328099250793,
-0.4766923785209656,
-0.4983535408973694,
-0.1512211263179779,
0.15805858373641968,
-0.12925684452056885,
0.08649824559688568,
-0.09650302678346634,
-0.22046799957752228,
-0.3452475965023041,
-0.34349432587623596,
-0.566188633441925,
0.1787433624267578,
-0.2709280848503113,
0.06729529798030853,
0.14229632914066315,
-0.28820496797561646,
-0.14352382719516754,
-0.04993889108300209,
0.2947234511375427,
0.4051750600337982,
-0.10565472394227982,
-0.46412280201911926,
0.2635369300842285,
-0.4227999746799469,
0.12431786954402924,
-0.0072015817277133465,
0.10287012159824371,
-0.5216354131698608,
0.4891713559627533,
0.05824079364538193,
0.549076497554779,
-0.0996217355132103,
-0.15129420161247253,
-0.9918240308761597,
0.198757603764534,
0.7993103861808777,
-0.055012933909893036,
0.4732285439968109,
0.2095499038696289,
0.3081023693084717,
0.10803427547216415,
-0.04894451051950455,
-0.06509073078632355,
-0.01112346351146698,
-0.08374320715665817,
-0.5309311747550964,
0.4735959470272064,
0.45538052916526794,
-0.061910003423690796,
0.07630524784326553,
0.5185180902481079,
-0.06325748562812805,
-0.4038155972957611,
0.1313641220331192,
0.39898809790611267,
-0.0059457095339894295,
0.1820290982723236,
-0.22099913656711578,
-0.905659556388855,
0.2633800506591797,
0.28124597668647766,
-0.45924070477485657,
0.2623569965362549,
0.2515544891357422,
-0.12427216023206711,
-0.26666194200515747,
0.3060694634914398,
0.12120923399925232,
-0.3677038550376892,
-0.5226491093635559,
-0.981421947479248,
0.10934159904718399,
0.3378217816352844,
0.7178846597671509,
0.0492129847407341,
0.6673893928527832,
-0.23042722046375275,
-0.2909930944442749,
-0.15580548346042633,
0.45267948508262634,
0.3119173049926758,
-0.4894872307777405,
-0.457709938287735,
-0.12096133083105087,
0.37650197744369507,
-0.3904556334018707,
0.04659474268555641,
0.6458317637443542,
1.010566234588623,
-0.025282077491283417,
-0.2065482884645462,
0.11847691237926483,
-0.20598186552524567,
0.1872468739748001,
-0.47099223732948303,
0.1918959617614746,
-0.4123799204826355,
-0.1767735779285431,
-0.023924272507429123,
0.1055544912815094,
0.11677129566669464,
-1.048164963722229,
0.3129864037036896,
-0.1297936886548996,
-0.2503485679626465,
0.025233805179595947,
0.9570906162261963,
0.1849905550479889,
-0.12731920182704926,
0.09506973624229431,
-0.04798546060919762,
0.3601285219192505,
0.22763840854167938,
0.12706619501113892,
0.012276999652385712,
-0.23962529003620148,
0.6251798868179321,
-0.6598671078681946,
0.35114866495132446,
-0.7944364547729492,
-0.1221674308180809,
-0.49944639205932617,
0.3989744186401367,
-0.41450175642967224,
-0.6419632434844971,
0.1640816479921341,
-0.7587770223617554,
-0.05954757705330849,
-0.046711552888154984,
0.19619576632976532,
0.3811696171760559,
0.2307581752538681,
0.1376296877861023,
0.5129882097244263,
-0.4860575199127197,
0.37302854657173157,
0.20533624291419983,
-0.01788277179002762,
-0.3696542978286743,
0.10946192592382431,
0.3150797188282013,
-0.01585850864648819,
-0.44754689931869507,
0.09222845733165741,
0.055517856031656265,
-0.2955811619758606,
0.7955617904663086,
0.1796189248561859,
-0.2058599591255188,
0.06599574536085129,
0.18731196224689484,
-0.19918128848075867,
0.2053038626909256,
0.41269874572753906,
0.014389215037226677,
0.6564006209373474,
0.7790249586105347,
-0.005632395390421152,
-0.19350813329219818,
0.49311158061027527,
-0.021020669490098953,
0.2872633635997772,
0.06037518382072449,
0.9176350235939026,
0.4551592469215393,
-0.025371670722961426,
0.2036714106798172,
0.3100115954875946,
0.42122140526771545,
0.20022204518318176,
0.14654237031936646,
-0.09961342811584473,
-0.33723777532577515,
0.10477971285581589,
0.568697988986969,
0.5406442880630493,
-0.4622035026550293,
-0.3229319155216217,
0.21046987175941467,
0.41038909554481506,
0.13846372067928314,
0.06774158030748367,
-0.04908644035458565,
0.5908840298652649,
0.19878233969211578,
-0.2761452794075012,
-0.6774792671203613,
-0.03477168083190918,
-0.776467502117157,
0.32841184735298157,
0.7002490758895874,
-0.4424380958080292,
-0.23916590213775635,
0.16462409496307373,
-0.14112596213817596,
-0.03292657434940338,
0.09037908166646957,
0.7064351439476013,
-0.4996294677257538,
0.044352252036333084,
0.476223886013031,
-0.0330711230635643,
0.3504162132740021,
0.02652399241924286,
-0.2977294921875,
0.19928835332393646,
0.03738793730735779,
0.6700061559677124,
-0.09034746885299683,
-0.4848068952560425,
0.11666399240493774,
-0.3899327218532562,
0.03828134387731552,
0.5757675766944885,
0.007086330559104681,
-0.029299631714820862,
-0.2040972262620926,
-0.9797742366790771,
-0.32628387212753296,
-0.45868638157844543,
-0.5243921279907227,
-0.0861750990152359,
0.052105482667684555,
-0.006184844765812159,
0.1475570946931839,
-0.684492290019989,
0.2878151834011078,
-0.09335257112979889,
0.0888369083404541,
-0.1692916303873062,
-0.14273597300052643,
0.45963168144226074,
0.07855701446533203,
0.21388737857341766,
-0.1891850084066391,
0.48306483030319214,
-0.14965946972370148,
0.22609059512615204,
0.06746222078800201,
0.3576326072216034,
-0.42488327622413635,
-0.21345622837543488,
0.010440587066113949,
-0.5495755672454834,
1.1907386779785156,
0.6834579706192017,
-0.34860026836395264,
0.1153990775346756,
0.4546625018119812,
0.16366475820541382,
0.26299265027046204,
-0.5714001059532166,
-0.435622900724411,
-0.7154757976531982,
-0.106838658452034,
-0.5488438010215759,
0.6936963200569153,
0.09769897162914276,
-0.19203554093837738,
0.06507249176502228,
0.5393944978713989,
0.033352337777614594,
-0.26828432083129883,
0.6929901838302612,
-0.33843061327934265,
-0.3873857855796814,
-0.748996913433075,
0.1850605010986328,
-0.36174461245536804,
0.1694706380367279,
-0.6908693909645081,
0.47432616353034973,
0.5544964075088501,
0.3799952268600464,
0.01632164791226387,
-0.016820361837744713,
0.5226705074310303,
0.036755938082933426,
0.23729440569877625,
0.024363558739423752,
-0.5785914659500122,
-0.9450142979621887,
-0.8876059055328369,
0.21220023930072784,
0.6459354162216187,
-0.6072435975074768,
-0.23380789160728455,
0.279834508895874,
0.04602068290114403,
0.2648990750312805,
0.013168714009225368,
-0.45039793848991394,
-0.19576813280582428,
-0.015428261831402779
] |
Problem Samoa has been struggling to address the burden of noncommunicable diseases at the health system, community and individual levels. Approach The World Health Organization (WHO) package of essential noncommunicable disease interventions for primary health care in low-resource settings was adopted in seven villages throughout Samoa in 2015. The National Steering Committee Members designed and implemented a screening process, and local facilitators and health-care workers collected health and lifestyle data. The WHO/International Society of Hypertension risk assessment was used on villagers older than 40 years to identify people at high risk of noncommunicable disease. Local setting Samoa is a small island developing state with increasing morbidity and mortality due to noncommunicable diseases. A national representative survey indicated that 50.1% (595/1188) of the Samoan adult population is at high risk of such diseases. High numbers of noncommunicable diseases are undiagnosed or untreated, because of shortage of health-care staff and lack of awareness of risk factors. Relevant changes The teams collected data from 2234 adults. For people older than 40 years, 6.7% (54/804) were identified as being at high-risk and were encouraged to seek treatment or manage risk factors. Community members developed an awareness programme to improve understanding of lifestyle risk factors. Lessons learnt Engaging community members was crucial in conducting a successful screening campaign. By identifying those villagers at high risk of developing noncommunicable diseases, early intervention was possible. Education improved awareness of the symptom-free nature of early-stage noncommunicable diseases. | [
0.010206762701272964,
-0.0016113996971398592,
-0.005477423779666424,
0.01696314476430416,
-0.0037773889489471912,
0.0024261882063001394,
0.010316692292690277,
0.022791454568505287,
-0.017837414517998695,
-0.015687361359596252,
-0.011003989726305008,
0.01039039809256792,
0.0008581224246881902,
0.0185275636613369,
-0.019050506874918938,
-0.015544257126748562,
-0.006448233034461737,
0.028283292427659035,
0.01289660669863224,
0.0165106151252985,
-0.011567370966076851,
-0.001742400461807847,
0.010063796304166317,
0.026471130549907684,
0.03084784746170044,
0.03392758220434189,
0.0001262947916984558,
-0.003674475708976388,
-0.028345005586743355,
0.04352082312107086,
-0.016847923398017883,
0.019219284877181053,
0.011974334716796875,
-0.0052602700889110565,
0.007732221391052008,
-0.03186800330877304,
-0.0002010802272707224,
0.01786157861351967,
-0.0040918500162661076,
-0.005705718882381916,
0.011536994017660618,
-0.007650838233530521,
-0.0032616634853184223,
0.00834096409380436,
-0.008487163111567497,
0.00972935650497675,
-0.0062173279002308846,
-0.016028694808483124,
-0.004430013708770275,
0.013522450812160969,
0.008748766034841537,
0.0006757774390280247,
-0.009750083088874817,
-0.02008661814033985,
-0.006331736221909523,
-0.0045224567875266075,
0.021251847967505455,
-0.0000615434255450964,
-0.012701217085123062,
-0.0200684554874897,
-0.002322224900126457,
0.0001928072888404131,
0.0068566882982850075,
0.004610997624695301,
0.007969789206981659,
-0.06651218235492706,
-0.00942724384367466,
0.0011217910796403885,
-0.026063088327646255,
-0.01646357774734497,
0.0189642533659935,
0.013219844549894333,
0.008224689401686192,
-0.013244248926639557,
-0.03161612153053284,
-0.00043129525147378445,
0.0148269422352314,
0.0009209355339407921,
0.030991917476058006,
0.016843952238559723,
-0.005068577826023102,
-0.009038201533257961,
-0.020191282033920288,
0.006025073584169149,
0.01126231998205185,
-0.011435773223638535,
-0.025073327124118805,
-0.00020205497276037931,
0.00910650473088026,
0.007051898632198572,
0.0320771187543869,
-0.012020247057080269,
-0.018170908093452454,
-0.00469027366489172,
0.01077520102262497,
-0.006026335060596466,
-0.014083628542721272,
0.035659193992614746,
0.009298478253185749,
0.00393384974449873,
-0.012342606671154499,
-0.00421646423637867,
0.02283959463238716,
-0.01240424532443285,
-0.00010579358786344528,
0.005536576267331839,
0.0064049698412418365,
0.0261952206492424,
0.006554413586854935,
0.009354242123663425,
0.010949509218335152,
0.03604899346828461,
0.0050200470723211765,
0.010786255821585655,
0.02891770377755165,
-0.02392924390733242,
0.029236072674393654,
-0.01456931047141552,
0.016647707670927048,
0.011588595807552338,
0.013442701660096645,
-0.042287979274988174,
-0.010032515041530132,
0.009332019835710526,
-0.0013338756980374455,
0.025039099156856537,
-0.009619729593396187,
0.018176816403865814,
-0.034693192690610886,
-0.003512520808726549,
-0.011490439996123314,
0.01257955003529787,
-0.014738565310835838,
-0.0136845288798213,
-0.001907947240397334,
-0.005895370617508888,
-0.03844885155558586,
0.010633260011672974,
0.01081590261310339,
0.00834854505956173,
-0.0194874107837677,
0.012134121730923653,
-0.0032103650737553835,
0.009285205975174904,
0.007344407960772514,
0.0012790176551789045,
-0.012870123609900475,
0.009846008382737637,
0.02876591682434082,
0.004561323206871748,
-0.0059782578609883785,
-0.01062320638448,
0.037542007863521576,
-0.01599637232720852,
-0.002047271002084017,
-0.0002574163954705,
-0.029781026765704155,
-0.0026879566721618176,
-0.023347409442067146,
0.004240297246724367,
0.00539782177656889,
0.02001209557056427,
-0.02180204913020134,
0.007594433147460222,
0.03903580456972122,
0.007080379873514175,
0.04464338347315788,
0.008933283388614655,
-0.010340847074985504,
0.0076710996218025684,
-0.00895192101597786,
-0.018538732081651688,
0.013425418175756931,
0.004057927988469601,
-0.0037864039186388254,
-0.009196548722684383,
0.018953535705804825,
0.007205345202237368,
-0.0016947605181485415,
0.06614765524864197,
-0.0018124659545719624,
-0.018872089684009552,
-0.004862042609602213,
0.002586792688816786,
0.00655784597620368,
-0.009258346632122993,
0.01930258981883526,
0.002055027522146702,
0.006650353781878948,
0.024087484925985336,
0.0028228715527802706,
-0.014836041256785393,
0.006094519980251789,
0.002655909862369299,
0.01242227666079998,
0.0038451903965324163,
0.014915842562913895,
0.01433659065514803,
-0.015728864818811417,
0.0249076709151268,
0.03937506303191185,
0.004066796507686377,
0.006480478215962648,
0.007784160319715738,
-0.023768294602632523,
0.006821982562541962,
-0.00811188854277134,
-0.00041028321720659733,
0.0038229667115956545,
-0.010094258934259415,
0.00975009985268116,
0.003134393598884344,
0.0048535410314798355,
-0.021470405161380768,
-0.019366106018424034,
-0.016437333077192307,
0.005027014762163162,
0.05235535278916359,
-0.017077714204788208,
-0.018839066848158836,
-0.013698795810341835,
0.010087123140692711,
-0.01577521301805973,
0.020755009725689888,
0.015599872916936874,
0.010642258450388908,
0.0075570158660411835,
0.013468710705637932,
0.02347135916352272,
0.0057488540187478065,
-0.01407213881611824,
0.002041742205619812,
-0.011266741901636124,
-0.00005842710379511118,
-0.020326094701886177,
0.02402377501130104,
0.012697865255177021,
-0.02354591153562069,
0.02438732050359249,
-0.02152949571609497,
0.005034161731600761,
-0.02276453748345375,
0.03130684792995453,
-0.010908368974924088,
-0.011298464611172676,
0.019567500799894333,
0.014502832666039467,
-0.01210777461528778,
-0.027480758726596832,
0.014515845105051994,
0.007818499580025673,
0.007101054769009352,
0.0314602330327034,
0.014119465835392475,
0.037610169500112534,
-0.0030097700655460358,
-0.037074439227581024,
-0.012288181111216545,
0.027450907975435257,
0.0003441569861024618,
0.0032141723204404116,
0.004928022623062134,
-0.0076578520238399506,
-0.005982168950140476,
0.008612940087914467,
0.017706098034977913,
0.01605341024696827,
-0.003549029352143407,
-0.015988275408744812,
-0.004107882268726826,
0.0067817410454154015,
-0.010311725549399853,
0.0010626169387251139,
-0.081679567694664,
-0.0034288354218006134,
0.01927591674029827,
-0.003951350226998329,
0.013997065834701061,
-0.0032674986869096756,
0.0267849899828434,
0.03048304095864296,
-0.012441221624612808,
0.03127118945121765,
0.0076136235147714615,
0.007172774523496628,
-0.013903461396694183,
-0.010160992853343487,
0.01746854931116104,
-0.005319777876138687,
0.00047341245226562023,
0.012914912775158882,
-0.02586580440402031,
0.0045227110385894775,
-0.044055599719285965,
-0.016261447221040726,
0.03989928588271141,
-0.017512712627649307,
0.0015182180795818567,
0.02082006260752678,
-0.004554955288767815,
-0.011223231442272663,
-0.0014270073734223843,
0.006390631198883057,
0.0036399485543370247,
0.0009350681211799383,
0.02757609263062477,
-0.052731648087501526,
0.002730611013248563,
-0.0023214323446154594,
0.024947388097643852,
-0.0013347319327294827,
0.0007375534623861313,
0.009999547153711319,
0.01840163581073284,
0.011058168485760689,
0.015785256400704384,
0.002743544289842248,
-0.0028600217774510384,
0.010924337431788445,
0.017822392284870148,
0.03108735755085945,
0.017184283584356308,
0.0024408684112131596,
-0.00401095999404788,
-0.0028892189729958773,
0.004140730015933514,
0.011460614390671253,
-0.02904282696545124,
-0.009786991402506828,
-0.018713729456067085,
-0.006930661387741566,
-0.004091973416507244,
-0.00845404528081417,
0.0035516642965376377,
-0.002989955712109804,
0.015440322458744049,
0.011159702204167843,
-0.010628962889313698,
-0.027096617966890335,
0.0035195774398744106,
-0.01641034334897995,
-0.01991421915590763,
0.003308922052383423,
0.022639945149421692,
-0.0036015585064888,
-0.01907660812139511,
-0.00907774455845356,
-0.005407515447586775,
-0.0031442039180547,
-0.018110429868102074,
0.002270618686452508,
-0.02282465249300003,
0.005138230510056019,
-0.0422210618853569,
0.032834529876708984,
-0.024491457268595695,
-0.000784554984420538,
-0.007567462977021933,
0.01601666584610939,
0.018347768113017082,
-0.0009560270700603724,
0.01203210186213255,
-0.02269764617085457,
0.017315059900283813,
0.022589264437556267,
0.00911439023911953,
0.009662138298153877,
0.022395629435777664,
0.006652150768786669,
-0.007386952172964811,
0.0006394711090251803,
0.005031149368733168,
0.008514495566487312,
-0.020145993679761887,
-0.022746175527572632,
0.008925527334213257,
-0.015952439978718758,
0.022828496992588043,
0.012246177531778812,
0.02681325376033783,
-0.030777376145124435,
-0.004447667393833399,
-0.011840222403407097,
-0.011937076225876808,
0.004586332943290472,
0.004604893736541271,
0.0053169806487858295,
0.008831018581986427,
-0.00201552570797503,
0.007855787873268127,
-0.00240298081189394,
0.07147376984357834,
0.017914433032274246,
-0.009900196455419064,
0.0002979194396175444,
0.020517773926258087,
-0.004720254801213741,
-0.032735101878643036,
0.0021111173555254936,
-0.025090061128139496,
-0.035200249403715134,
0.015012074261903763,
-0.009909162297844887,
-0.0044960519298911095,
-0.011874344199895859,
0.005226132459938526,
-0.00526797492057085,
-0.016116879880428314,
-0.008754322305321693,
0.007185859605669975,
-0.00369370193220675,
0.006529449950903654,
0.0030135896522551775,
-0.012032732367515564,
0.007947541773319244,
0.008230073377490044,
-0.011802087537944317,
0.01586126536130905,
-0.01294406782835722,
-0.007618715520948172,
0.0019112247973680496,
0.0014934635255485773,
0.02334459312260151,
-0.009471096098423004,
-0.014119978062808514,
0.02712767943739891,
-0.02225775644183159,
0.010895440354943275,
0.018759924918413162,
-0.0017584414454177022,
-0.0043122130446136,
-0.0134347565472126,
-0.009574112482368946,
0.011243948712944984,
0.016810450702905655,
0.010140668600797653,
0.013240385800600052,
0.011710027232766151,
-0.005433534272015095,
-0.025481287389993668,
0.026856768876314163,
0.00968905445188284,
0.004663243889808655,
0.006479829084128141,
0.01896090991795063,
-0.023192869499325752,
-0.0058757709339261055,
0.008339913561940193,
0.003844485618174076,
0.0034546435344964266,
-0.008495395071804523,
-0.010547861456871033,
-0.010646481066942215,
0.03835409879684448,
0.014238770119845867,
0.008292391896247864,
-0.012607064098119736,
0.02439461089670658,
0.024220656603574753,
-0.023660533130168915,
-0.008251853287220001,
-0.05953957512974739,
-0.013149206526577473,
-0.0056596556678414345,
-0.007433336228132248,
-0.026361241936683655,
-0.012541687116026878,
-0.01822873391211033,
0.014997519552707672,
0.021764477714896202,
-0.04325710982084274,
-0.00726010836660862,
0.008822918869554996,
-0.004966793581843376,
-0.0008958331309258938,
0.015417712740600109,
-0.011250695213675499,
-0.02626405656337738,
-0.07488298416137695,
-0.009241504594683647,
0.011436691507697105,
-0.008950663730502129,
0.0043550715781748295,
-0.01752445474267006,
-0.019487496465444565,
0.04759794473648071,
-0.029214899986982346,
-0.009721439331769943,
-0.018791429698467255,
0.006167546845972538,
0.03691611438989639,
-0.0056354873813688755,
0.015269311144948006,
0.004315503407269716,
-0.005295814014971256,
-0.019986331462860107,
-0.005079573951661587,
0.00038828974356874824,
-0.015644308179616928,
0.0036131367087364197,
-0.002632089192047715,
0.009846560657024384,
0.00386367947794497,
-0.08041132986545563,
-0.01266685500741005,
0.017397480085492134,
-0.05554613843560219,
-0.024809202179312706,
0.031797949224710464,
0.008832946419715881,
-0.019474010914564133,
-0.013334873132407665,
-0.016758311539888382,
-0.004453947767615318,
0.028603438287973404,
0.03481090068817139,
-0.006171819753944874,
0.0003662952221930027,
-0.0073717148043215275,
0.029306039214134216,
-0.016247518360614777,
0.014917634427547455,
-0.011251125484704971,
-0.014640266075730324,
0.010072220116853714,
-0.006697473116219044,
0.00940718688070774,
-0.012975933030247688,
-0.024998564273118973,
0.009797954931855202,
0.021870046854019165,
-0.004837199579924345,
-0.009188394993543625,
0.0011213896796107292,
0.022813783958554268,
0.010910415090620518,
-0.006581272929906845,
0.018097760155797005,
-0.0032331307884305716,
-0.002938278019428253,
0.0004046936519443989,
0.02193797193467617,
-0.02004830539226532,
-0.0030782693065702915,
0.0075209178030490875,
-0.01722670905292034,
0.010730876587331295,
0.030796440318226814,
0.0031459180172532797,
0.013195138424634933,
-0.001674477942287922,
0.02310371957719326,
0.007455543614923954,
0.003640628419816494,
-0.0017540543340146542,
-0.005831147078424692,
-0.005086889956146479,
0.004428892862051725,
0.009837896563112736,
-0.003077898407354951,
0.004200556315481663,
-0.0159512497484684,
0.014885388314723969,
-0.011401530355215073,
0.008071290329098701,
0.021193962544202805,
0.07121381163597107,
-0.029954731464385986,
-0.003325473517179489,
0.00893666036427021,
0.007979679852724075,
-0.001518762786872685,
-0.01013691071420908,
0.02770755998790264,
-0.02609834633767605,
0.011389421299099922,
0.0042562526650726795,
-0.0014507736777886748,
-0.022007403895258904,
0.015612974762916565,
0.024490945041179657,
-0.007098354399204254,
0.0014017561916261911,
0.008792315609753132,
-0.0033377232030034065,
0.003791852854192257,
0.00033631641417741776,
0.0027834440115839243,
-0.03107491508126259,
0.022553257644176483,
0.024551689624786377,
0.003419790416955948,
-0.008885499089956284,
0.03360702097415924,
-0.011292455717921257,
0.008906558156013489,
-0.006296596024185419,
0.0013974894536659122,
0.008771234191954136,
-0.0017462065443396568,
0.0156614538282156,
0.0007035257294774055,
0.022998400032520294,
0.0072426460683345795,
-0.015154930762946606,
0.00933652650564909,
0.038221023976802826,
-0.0208310354501009,
0.029778121039271355,
-0.04281871020793915,
-0.006702534854412079,
-0.011476238258183002,
0.012555625289678574,
-0.004511228762567043,
0.034239038825035095,
0.01279902271926403,
0.0209527388215065,
0.005351597443223,
-0.020377319306135178,
0.01718010939657688,
-0.003328656777739525,
0.02426091767847538,
0.002386857056990266,
0.016830433160066605,
-0.002277257852256298,
-0.015835333615541458,
-0.006596308201551437,
-0.009962993673980236,
0.025202035903930664,
-0.008958963677287102,
0.02962675876915455,
-0.010298404842615128,
-0.0023546176962554455,
-0.015398973599076271,
-0.01311249565333128,
0.00717705674469471,
0.0015916049014776945,
-0.014821933582425117,
0.004305649548768997,
-0.022704966366291046,
0.03282978758215904,
-0.00428127683699131,
-0.0061953323893249035,
-0.010545140132308006,
0.004123905673623085,
0.007101541385054588,
-0.01881711557507515,
-0.02070801705121994,
-0.007967229001224041,
-0.0009423785377293825,
-0.030523281544446945,
-0.002449232153594494,
0.014012644067406654,
-0.008539130911231041,
-0.013216841965913773,
0.015145804733037949,
0.015029961243271828,
0.014585072174668312,
-0.003123468952253461,
0.003890514839440584,
0.013691479340195656,
0.03645528107881546,
-0.03986898809671402,
0.012611551210284233,
0.00873315054923296,
0.012404615059494972,
0.028232358396053314,
0.0036973124369978905,
-0.00026686873752623796,
-0.00913244765251875,
-0.030980922281742096,
-0.004744604229927063,
0.02496093139052391,
-0.01089577004313469,
0.027049601078033447,
-0.004408484790474176,
-0.03246031329035759,
0.01668374612927437,
0.025094641372561455,
-0.002525359159335494,
0.00519830035045743,
0.0013348688371479511,
-0.0065077487379312515,
0.008839916437864304,
0.007162529043853283,
-0.013107893988490105,
-0.03862421214580536,
-0.01727079600095749,
0.006806040648370981,
0.013315524905920029,
-0.021520931273698807,
-0.01931273564696312,
-0.0008290921105071902,
-0.01336743775755167,
0.0061197164468467236,
0.0013352259993553162,
0.013502055779099464,
-0.02193251997232437,
0.008394655771553516,
-0.01650434546172619,
-0.007099505979567766,
0.0005262871272861958,
0.010023672133684158,
0.0070383851416409016,
-0.013260843232274055,
-0.010659516789019108,
0.026484400033950806,
0.016089074313640594,
0.0030229436233639717,
-0.00844774954020977,
0.009275446645915508,
0.024043656885623932,
-0.003183983964845538,
0.004393148235976696,
0.01125967688858509,
0.012941267341375351,
0.01295725628733635,
0.010084521025419235,
-0.011617729440331459,
-0.0011949663748964667,
-0.012572100386023521,
0.011869783513247967,
-0.010971940122544765,
-0.02192503586411476,
-0.006907586008310318,
-0.029757369309663773,
-0.011895975098013878,
0.006789046805351973,
-0.013774722814559937,
0.00010616611689329147,
-0.005791164468973875,
0.04189249873161316,
-0.02146529220044613,
0.003101264126598835,
0.014290101826190948,
0.015456908382475376,
0.020047806203365326,
-0.020843839272856712,
-0.012017552740871906,
-0.0023788362741470337,
-0.0012815147638320923,
0.004578670486807823,
0.013851766474545002,
-0.014558030292391777,
0.000721699558198452,
0.002069174312055111,
-0.016383366659283638,
0.014331948012113571,
-0.012256057001650333,
-0.011340402066707611,
-0.001434784266166389,
0.01247691735625267,
-0.00511906249448657,
-0.012044768780469894,
0.007281871512532234,
0.006629042327404022,
-0.017139114439487457,
-0.034365057945251465,
-0.01093699224293232,
0.006437742151319981,
0.020413117483258247,
0.009264802560210228,
-0.005902060307562351,
-0.02209678292274475,
-0.0057249516248703,
-0.004091937094926834,
0.0059368303045630455,
-0.006041192449629307
] | [
0.3342747390270233,
-0.05620887503027916,
-0.10950901359319687,
-0.38291507959365845,
-0.2563481330871582,
0.5684524178504944,
0.49875980615615845,
-0.2506074607372284,
-0.6089691519737244,
-0.23384352028369904,
-0.06472127139568329,
0.5035573244094849,
-0.5175920128822327,
0.41254377365112305,
-0.18525488674640656,
0.5627134442329407,
0.6125337481498718,
0.4695468544960022,
-0.25169849395751953,
0.06434860825538635,
-0.72779780626297,
-0.3956204950809479,
0.5154277086257935,
0.20207004249095917,
-0.15172380208969116,
-0.12038837373256683,
0.8524514436721802,
0.4851728081703186,
-0.29406610131263733,
0.12208839505910873,
0.13458023965358734,
0.6413740515708923,
-0.08648692816495895,
-0.27045944333076477,
-0.3483341336250305,
0.279249906539917,
0.4845549762248993,
-0.18856152892112732,
0.0248632300645113,
0.2736770808696747,
0.36523011326789856,
-0.35642263293266296,
-0.30034106969833374,
0.28643643856048584,
0.24795272946357727,
-0.1397087723016739,
-1.3271299600601196,
0.31671321392059326,
-0.4425036907196045,
0.3318682014942169,
-0.8008893132209778,
0.3562554717063904,
0.16716280579566956,
-0.09957054257392883,
0.2083490937948227,
0.6130475401878357,
-0.4311671257019043,
-0.20596295595169067,
0.13194023072719574,
-0.2962062656879425,
0.10699555277824402,
-0.025396332144737244,
0.23918752372264862,
-0.30619630217552185,
-0.45755016803741455,
0.011456822045147419,
0.028902238234877586,
0.2520592510700226,
-0.10293813794851303,
-0.6327511668205261,
-0.0818847194314003,
-0.14069437980651855,
-0.6259549260139465,
-0.248182013630867,
-0.07340157777070999,
0.0023974620271474123,
-0.5291547179222107,
0.19850212335586548,
0.11282846331596375,
0.17328880727291107,
-0.17169232666492462,
0.20967671275138855,
0.2846018671989441,
-0.572463870048523,
0.36688533425331116,
-0.3854837119579315,
0.8002967238426208,
0.5767576694488525,
0.48267433047294617,
0.4154336154460907,
0.31086817383766174,
-0.4199633300304413,
0.30053794384002686,
0.17915824055671692,
0.37706345319747925,
0.25990042090415955,
0.03477512672543526,
0.34675753116607666,
0.6563510298728943,
0.1451175957918167,
0.04563015699386597,
0.2795614004135132,
0.4212796986103058,
0.45834124088287354,
-0.540073812007904,
-0.8658323884010315,
0.06125537306070328,
-0.121597059071064,
-0.6208391785621643,
0.13454288244247437,
-0.7480834722518921,
0.028821485117077827,
-0.23661445081233978,
-0.1576354205608368,
0.04027511179447174,
0.42400240898132324,
0.17443591356277466,
-0.24693331122398376,
-0.7064446806907654,
-0.22617854177951813,
-0.21069929003715515,
0.13348442316055298,
-0.18858899176120758,
0.5315221548080444,
0.07437270134687424,
0.2927095890045166,
0.8160832524299622,
0.5551403760910034,
-0.42894983291625977,
0.36944907903671265,
0.30136433243751526,
0.16882704198360443,
-0.49125009775161743,
-0.10323668271303177,
0.4002462327480316,
-0.6402999758720398,
-0.28238576650619507,
0.01417087484151125,
0.5662721991539001,
-0.1900254637002945,
-0.27333107590675354,
-0.07253873348236084,
-0.37068456411361694,
0.11009995639324188,
0.019365429878234863,
0.20719176530838013,
-0.382798433303833,
-0.5033153891563416,
0.09301590174436569,
-0.3243289291858673,
0.2671334147453308,
-0.24848155677318573,
0.2961425185203552,
0.15836364030838013,
0.0015903986059129238,
0.2907092869281769,
0.24040845036506653,
-0.3741471767425537,
0.06896837055683136,
0.2510903477668762,
0.43334728479385376,
0.06525202840566635,
-0.2332678586244583,
0.02978592924773693,
0.5254365801811218,
0.21253828704357147,
-0.20782257616519928,
0.23160700500011444,
1.124545931816101,
0.2371612936258316,
-0.532647967338562,
-0.04928077384829521,
-0.5435817837715149,
-0.23759225010871887,
-0.5821701288223267,
-0.7581931948661804,
0.35808369517326355,
0.12689493596553802,
-0.18647459149360657,
0.026242418214678764,
-0.7344866394996643,
0.12377356737852097,
0.3275878131389618,
0.08304625749588013,
-0.1571904420852661,
0.3943096399307251,
0.178595170378685,
0.007339904084801674,
0.322843998670578,
0.2839244604110718,
0.19643044471740723,
-0.5379687547683716,
1.0432268381118774,
-0.4467373192310333,
1.0138267278671265,
0.28620806336402893,
-0.5254876017570496,
1.5688652992248535,
0.17559632658958435,
0.1353965699672699,
0.2768753468990326,
0.37252333760261536,
0.8002927303314209,
0.06327717006206512,
-1.3961769342422485,
-0.10936322063207626,
-0.17046798765659332,
0.34381914138793945,
-0.22169865667819977,
-0.21296247839927673,
0.04871899262070656,
-0.0713559091091156,
-0.4392341375350952,
-0.12734171748161316,
-0.090019591152668,
0.196527361869812,
-0.019492819905281067,
-0.028093649074435234,
0.05337030068039894,
-0.19069477915763855,
0.1960105001926422,
-0.03951948136091232,
0.13315452635288239,
0.4401247203350067,
0.26164957880973816,
0.39701661467552185,
0.82039874792099,
-0.33449724316596985,
0.7297494411468506,
-0.09134836494922638,
-0.07227141410112381,
0.39168331027030945,
0.6265385150909424,
-0.4620390236377716,
0.1290658563375473,
0.4420221447944641,
-0.070524200797081,
-0.14372234046459198,
-0.025020325556397438,
0.11666400730609894,
-0.10244327783584595,
0.1684449017047882,
-0.7251736521720886,
-0.0226985365152359,
0.4720240533351898,
0.06944191455841064,
-0.5567572116851807,
0.136703222990036,
-0.3671298623085022,
0.10031460970640182,
0.35655590891838074,
0.12133605033159256,
0.12173671275377274,
-0.13434672355651855,
-0.08858871459960938,
-0.17087742686271667,
-0.14494185149669647,
-0.48111459612846375,
0.1930038332939148,
-0.7108097076416016,
-0.2977486252784729,
0.061457403004169464,
0.04036007449030876,
-0.09153969585895538,
0.7733441591262817,
-0.8196753859519958,
0.08866172283887863,
-0.4856349527835846,
-0.20572642982006073,
0.35384324193000793,
0.40054234862327576,
-0.021262552589178085,
-0.5915089249610901,
-0.23947089910507202,
-0.37493690848350525,
0.09447178244590759,
-0.2854815125465393,
0.6346283555030823,
-0.5824750661849976,
-0.26113709807395935,
-0.0036591908428817987,
0.4363529682159424,
0.1717914193868637,
-0.8004336953163147,
-0.32187125086784363,
0.01416047103703022,
0.0309726744890213,
-0.5683409571647644,
-0.9166187047958374,
0.24055340886116028,
-0.10295747965574265,
-0.5336893200874329,
-0.32322004437446594,
-0.2453712671995163,
0.5228687524795532,
-0.006428135093301535,
-0.39085063338279724,
0.39146557450294495,
0.9492431282997131,
-0.06816669553518295,
0.29764705896377563,
0.04395313933491707,
-0.34999579191207886,
-0.3961224853992462,
-0.15045402944087982,
-0.05426836013793945,
-0.39460691809654236,
-0.592825174331665,
-5.870683670043945,
-0.0275986660271883,
-0.13203547894954681,
0.24835209548473358,
-0.7195677757263184,
0.034690529108047485,
0.557050347328186,
0.020096484571695328,
0.9387951493263245,
-0.15829385817050934,
0.03280572220683098,
0.47227466106414795,
-0.022268738597631454,
0.36086106300354004,
0.16778874397277832,
0.45099741220474243,
0.6511431932449341,
-0.13051261007785797,
0.22699108719825745,
-0.06524799019098282,
-0.06426465511322021,
0.09847743064165115,
0.26741498708724976,
0.0871114507317543,
0.562711238861084,
0.4806818664073944,
-0.458554208278656,
0.17426155507564545,
-0.17821533977985382,
-0.32282257080078125,
-0.2940286099910736,
-0.13449309766292572,
0.3274826407432556,
-0.5398935675621033,
-0.21117989718914032,
0.16655327379703522,
0.22551551461219788,
0.22005896270275116,
-0.37709707021713257,
-0.6783963441848755,
-0.05782682076096535,
-0.4107142984867096,
0.389013409614563,
-0.546553373336792,
0.27326780557632446,
0.16462722420692444,
-0.006229607854038477,
-0.48513275384902954,
-0.5433235764503479,
0.9113529920578003,
0.6468938589096069,
-0.10225436836481094,
0.3076505661010742,
0.3420460522174835,
0.022664876654744148,
0.11155886203050613,
0.5399906635284424,
-0.15126168727874756,
-0.8281741738319397,
0.2919435203075409,
-0.11887292563915253,
-0.5365507006645203,
-0.00505589647218585,
-0.44841888546943665,
-0.5554383993148804,
0.7363309264183044,
-0.6039972305297852,
-0.21014012396335602,
0.36602282524108887,
-0.4803050756454468,
-0.7865223288536072,
0.10328497737646103,
-0.22445543110370636,
-0.5234653949737549,
-0.26692020893096924,
-0.6522387862205505,
-0.5366719961166382,
0.25006523728370667,
-0.06852709501981735,
-0.6462708711624146,
-0.6671788096427917,
-0.4530887305736542,
-0.11553821712732315,
0.1491604745388031,
0.6405119299888611,
-0.22052428126335144,
-0.051141638308763504,
-0.23302040994167328,
-0.08367282897233963,
0.3931671679019928,
0.21278026700019836,
-0.4889101982116699,
0.19305260479450226,
0.06226065382361412,
0.5964153409004211,
1.2381041049957275,
0.3656805157661438,
-0.2654704749584198,
0.5412182211875916,
-0.24330675601959229,
0.5395543575286865,
0.3556573987007141,
-0.27815163135528564,
0.09341464936733246,
0.256691038608551,
-0.023735718801617622,
-0.4425007998943329,
0.06584036350250244,
0.32817941904067993,
-0.6298306584358215,
0.169505313038826,
-0.317790687084198,
-0.8369243144989014,
0.33497482538223267,
0.35162895917892456,
0.04850110784173012,
0.14003616571426392,
0.6657214164733887,
0.7015648484230042,
-0.3472544252872467,
0.28694427013397217,
0.09378432482481003,
0.39612624049186707,
0.21446789801120758,
-0.27029722929000854,
-0.2764945328235626,
-0.24351201951503754,
0.3341762125492096,
-0.008104387670755386,
0.6361302137374878,
0.3682551085948944,
-0.12464842945337296,
0.09789504110813141,
-0.39650148153305054,
0.731903612613678,
0.027780257165431976,
-0.30057501792907715,
-0.5054224729537964,
-0.036965787410736084,
-0.30840006470680237,
0.03980593755841255,
-0.46957194805145264,
0.08276459574699402,
0.13310079276561737,
0.3681775629520416,
-0.14242781698703766,
-0.06500504165887833,
-0.21002909541130066,
-0.3845992982387543,
-0.006252409890294075,
-0.3189885914325714,
0.06703561544418335,
0.2842870056629181,
-0.43490856885910034,
-0.45963847637176514,
0.4208260774612427,
0.40093669295310974,
-0.03313271701335907,
-0.45265862345695496,
-0.3954996168613434,
0.6975719928741455,
-1.1050525903701782,
-0.7881174087524414,
-0.044844821095466614,
-0.0440623015165329,
-0.0013612172333523631,
-0.09393242001533508,
0.14865624904632568,
-0.6202356815338135,
0.31488868594169617,
0.437070369720459,
-0.07886295020580292,
-0.4031946361064911,
0.07003040611743927,
0.32471275329589844,
-0.8264918327331543,
-0.5001367330551147,
0.2763013243675232,
-0.07642804831266403,
0.45532816648483276,
-0.13837376236915588,
-0.45435595512390137,
-0.10356823354959488,
-0.07863462716341019,
0.6377350687980652,
-0.012169219553470612,
0.20178735256195068,
-0.2878982722759247,
-0.2862148582935333,
-0.2129601389169693,
0.2631397843360901,
0.09393647313117981,
0.3938494324684143,
0.3002333641052246,
0.23197133839130402,
-0.7991989850997925,
-0.19846458733081818,
0.6663361191749573,
-0.0658310055732727,
0.2736174166202545,
-0.39136359095573425,
0.278049111366272,
0.030303454026579857,
0.05583978816866875,
0.34131190180778503,
0.5002945065498352,
0.3099368214607239,
-0.39979830384254456,
-0.20068779587745667,
-0.2989233434200287,
-0.12849032878875732,
-0.11624418944120407,
-0.11960013955831528,
0.9282028079032898,
-0.5082155466079712,
0.11179269105195999,
-0.41787829995155334,
-0.07826828956604004,
-0.11851877719163895,
-0.035335347056388855,
0.2186318188905716,
-0.28909844160079956,
-0.44792965054512024,
-0.449655145406723,
-0.13993389904499054,
0.49468374252319336,
0.8740034699440002,
-1.1036226749420166,
-0.27976468205451965,
0.2248673141002655,
0.3506520986557007,
-0.47253844141960144,
0.2583063840866089,
-0.03730994090437889,
-0.2628096044063568,
0.12398183345794678,
-0.38726454973220825,
-0.18365363776683807,
0.11581725627183914,
0.8427122235298157,
-0.5651968121528625,
0.7783641219139099,
0.08804105222225189,
-0.9585534930229187,
-0.5456235408782959,
0.09369409829378128,
0.017683949321508408,
-0.15167072415351868,
-0.46116936206817627,
0.22295700013637543,
-0.36956220865249634,
0.12957142293453217,
-0.098914735019207,
-0.32952260971069336,
0.2340967059135437,
-0.22306498885154724,
-0.12944546341896057,
0.12475687265396118,
-0.2346157431602478,
-0.0960972011089325,
0.3066806197166443,
-0.2241113930940628,
-0.10704208165407181,
-0.10861069709062576,
0.6005829572677612,
0.07194612175226212,
-0.0157633014023304,
-0.7740183472633362,
0.0928998589515686,
-0.3221639096736908,
-0.4357011020183563,
-0.13288521766662598,
0.9186376333236694,
0.17480970919132233,
0.0754626989364624,
-0.5884622931480408,
-0.24609027802944183,
0.49713611602783203,
0.2417675256729126,
0.38582977652549744,
-0.03005862608551979,
0.07097389549016953,
0.17096547782421112,
0.012344283983111382,
0.4228459894657135,
-0.3189806342124939,
-0.2877906262874603,
0.2204006314277649,
0.05938448756933212,
-0.0720064640045166,
0.08305102586746216,
0.11692855507135391,
-0.23231497406959534,
-0.288553386926651,
-0.1259455382823944,
0.20446909964084625,
0.2509600520133972,
-0.09270630031824112,
-0.5342152118682861,
-0.4693261981010437,
-0.36632710695266724,
0.1669917106628418,
0.014168054796755314,
-0.22990797460079193,
0.34666335582733154,
-0.11423435062170029,
-0.039849407970905304,
-0.40552788972854614,
-0.04081835225224495,
0.3412817120552063,
0.44972047209739685,
0.057211317121982574,
0.4911547005176544,
0.7411574125289917,
-0.4423363208770752,
0.7365325093269348,
0.06377804279327393,
-0.42943668365478516,
-0.23998390138149261,
0.2340017855167389,
-0.0505618155002594,
-0.15934355556964874,
0.3255789577960968,
0.6994271278381348,
0.011688970029354095,
0.19142208993434906,
-0.08681195974349976,
0.42810121178627014,
0.4931943714618683,
0.6479289531707764,
0.03382240980863571,
0.21574686467647552,
0.11051146686077118,
-0.1357199251651764,
0.04984300211071968,
-0.0022872297558933496,
-0.05684463679790497,
-0.17713108658790588,
-0.4021230638027191,
0.207880437374115,
1.1917074918746948,
0.17403340339660645,
0.1366538107395172,
0.010567686520516872,
0.48642903566360474,
-0.07517894357442856,
0.17566965520381927,
-0.12669433653354645,
0.7344717979431152,
-0.11210750788450241,
0.6427178382873535,
0.16598378121852875,
-0.16737113893032074,
0.24480482935905457,
-0.5420743823051453,
-0.050627514719963074,
-0.28652825951576233,
-0.9156619906425476,
-0.27194997668266296,
0.031164690852165222,
0.12345205247402191,
-0.26471224427223206,
-0.3846098482608795,
0.2929591238498688,
-0.0984392762184143,
-0.3763221800327301,
0.6528078317642212,
0.3547533452510834,
0.09508644789457321,
-0.2917117476463318,
-0.19770649075508118,
-0.014423035085201263,
-0.1214379221200943,
0.47862526774406433,
-0.1819194108247757,
-0.4393489360809326,
0.21844646334648132,
-0.0479455403983593,
0.14170385897159576,
0.3236278295516968,
-0.10374294966459274,
-0.22135034203529358,
0.09875854104757309,
-0.21151061356067657,
0.09738446027040482,
-0.07644982635974884,
0.11852476000785828,
-0.11553254723548889,
0.3563472628593445,
0.09990626573562622,
-0.0755370631814003,
-0.3433299660682678,
-0.12200519442558289,
0.386251300573349,
-0.22575221955776215,
-0.07995069772005081,
0.19775554537773132,
0.5341971516609192,
0.1249011978507042,
-0.10434456169605255,
0.002821920905262232,
-0.5892055630683899,
0.14187246561050415,
0.31475207209587097,
0.0015625515952706337,
0.22969478368759155,
-0.114250548183918,
-0.08631563931703568,
-0.3703975975513458,
0.31565871834754944,
0.6949189305305481,
1.437514066696167,
-0.35914984345436096,
0.0492909736931324,
-0.011062159202992916,
0.7456081509590149,
0.09903348982334137,
-0.07548610866069794,
0.016901645809412003,
-0.39207273721694946,
-0.26825907826423645,
-1.0674686431884766,
0.4548441171646118,
0.055661506950855255,
-0.09944003820419312,
-0.5963800549507141,
-0.6123425364494324,
0.08462035655975342,
-0.3858964741230011,
0.30811282992362976,
-0.1502511352300644,
-0.16207189857959747,
0.0304555706679821,
-0.1917089819908142,
-0.43608996272087097,
0.17776118218898773,
0.07127711921930313,
0.12019198387861252,
0.21032120287418365,
-0.017677003517746925,
-0.15120695531368256,
-0.42556047439575195,
-0.0025168759748339653,
0.29050344228744507,
0.6677465438842773,
0.1667923629283905,
-0.02441987954080105,
0.22330887615680695,
-0.9059472680091858,
-0.12880539894104004,
-0.16234906017780304,
-0.18983295559883118,
0.18440455198287964,
-0.2731558382511139,
-0.5385758876800537,
-0.5852042436599731,
0.12623929977416992,
-0.3389609456062317,
-0.18367449939250946,
-0.2091003805398941
] |
Summary Background Alcohol use is a leading risk factor for death and disability, but its overall association with health remains complex given the possible protective effects of moderate alcohol consumption on some conditions. With our comprehensive approach to health accounting within the Global Burden of Diseases, Injuries, and Risk Factors Study 2016, we generated improved estimates of alcohol use and alcohol-attributable deaths and disability-adjusted life-years (DALYs) for 195 locations from 1990 to 2016, for both sexes and for 5-year age groups between the ages of 15 years and 95 years and older. Methods Using 694 data sources of individual and population-level alcohol consumption, along with 592 prospective and retrospective studies on the risk of alcohol use, we produced estimates of the prevalence of current drinking, abstention, the distribution of alcohol consumption among current drinkers in standard drinks daily (defined as 10 g of pure ethyl alcohol), and alcohol-attributable deaths and DALYs. We made several methodological improvements compared with previous estimates: first, we adjusted alcohol sales estimates to take into account tourist and unrecorded consumption; second, we did a new meta-analysis of relative risks for 23 health outcomes associated with alcohol use; and third, we developed a new method to quantify the level of alcohol consumption that minimises the overall risk to individual health. Findings Globally, alcohol use was the seventh leading risk factor for both deaths and DALYs in 2016, accounting for 2·2% (95% uncertainty interval [UI] 1·5–3·0) of age-standardised female deaths and 6·8% (5·8–8·0) of age-standardised male deaths. Among the population aged 15–49 years, alcohol use was the leading risk factor globally in 2016, with 3·8% (95% UI 3·2–4·3) of female deaths and 12·2% (10·8–13·6) of male deaths attributable to alcohol use. For the population aged 15–49 years, female attributable DALYs were 2·3% (95% UI 2·0–2·6) and male attributable DALYs were 8·9% (7·8–9·9). The three leading causes of attributable deaths in this age group were tuberculosis (1·4% [95% UI 1·0–1·7] of total deaths), road injuries (1·2% [0·7–1·9]), and self-harm (1·1% [0·6–1·5]). For populations aged 50 years and older, cancers accounted for a large proportion of total alcohol-attributable deaths in 2016, constituting 27·1% (95% UI 21·2–33·3) of total alcohol-attributable female deaths and 18·9% (15·3–22·6) of male deaths. The level of alcohol consumption that minimised harm across health outcomes was zero (95% UI 0·0–0·8) standard drinks per week. Interpretation Alcohol use is a leading risk factor for global disease burden and causes substantial health loss. We found that the risk of all-cause mortality, and of cancers specifically, rises with increasing levels of consumption, and the level of consumption that minimises health loss is zero. These results suggest that alcohol control policies might need to be revised worldwide, refocusing on efforts to lower overall population-level consumption. Funding Bill & Melinda Gates Foundation. | [
-0.004916651640087366,
0.012535033747553825,
-0.023642228916287422,
-0.003505696076899767,
0.02105012908577919,
-0.029990179464221,
0.00772270280867815,
-0.001468693371862173,
-0.007427351549267769,
-0.006633227225393057,
-0.0030577920842915773,
-0.002276661805808544,
0.011123561300337315,
0.022781454026699066,
0.009655557572841644,
-0.005359970033168793,
-0.03595440089702606,
0.011579782702028751,
0.008368550799787045,
-0.002620541490614414,
-0.014366229996085167,
-0.01271018572151661,
0.008036559447646141,
0.008909322321414948,
-0.013825453817844391,
0.018048424273729324,
0.026440497487783432,
0.011889242567121983,
0.008497534319758415,
-0.010401124134659767,
-0.013499520719051361,
0.006198849529027939,
-0.0047975871711969376,
0.012085068970918655,
0.015774331986904144,
-0.0318266898393631,
0.0027204849757254124,
0.006780876778066158,
-0.0009963675402104855,
-0.003640730632469058,
0.017095256596803665,
-0.009658033028244972,
0.0072111268527805805,
0.023811178281903267,
-0.008346118964254856,
-0.01607230305671692,
-0.006381578277796507,
-0.004026309587061405,
0.02007274143397808,
0.010845163837075233,
-0.011538345366716385,
-0.011070621199905872,
-0.014490965753793716,
-0.03458940610289574,
-0.0048880809918046,
-0.014662165194749832,
0.016506481915712357,
0.011834176257252693,
-0.01405382715165615,
0.02682020515203476,
-0.0025835754349827766,
-0.026827681809663773,
0.0040525710210204124,
-0.018378518521785736,
-0.001971328631043434,
-0.06732867658138275,
-0.017749657854437828,
0.008307592011988163,
0.0033650489058345556,
-0.02224152721464634,
-0.016225455328822136,
0.0048255170695483685,
0.02308366447687149,
-0.006850916426628828,
-0.00848067831248045,
0.0193425752222538,
0.01149392407387495,
0.0004953746683895588,
-0.008340577594935894,
-0.016795609146356583,
0.004285585135221481,
-0.006869922857731581,
-0.012092488817870617,
0.01782151870429516,
0.00810245517641306,
0.008840341120958328,
-0.0112460907548666,
-0.026696136221289635,
0.012032306753098965,
0.00414113886654377,
-0.005058945156633854,
-0.014246383681893349,
0.02561993896961212,
-0.005381487309932709,
-0.006937749683856964,
-0.021786924451589584,
0.006167777813971043,
0.02883925288915634,
0.007836490869522095,
-0.013925687409937382,
0.0019140883814543486,
-0.023515155538916588,
0.0065952930599451065,
0.004363423213362694,
-0.007499442435801029,
0.005417783744633198,
-0.02471930719912052,
-0.014629978686571121,
-0.015315541066229343,
0.005659667309373617,
-0.006955747492611408,
0.026620175689458847,
0.022457793354988098,
0.027902917936444283,
0.021914776414632797,
0.011156362481415272,
0.0012935043778270483,
-0.004130410961806774,
0.0020260263700038195,
0.0015631713904440403,
0.029682889580726624,
-0.00616583414375782,
-0.00568030122667551,
0.0409904345870018,
-0.0016642073169350624,
0.030534105375409126,
0.02064831741154194,
0.001197895035147667,
-0.013806983828544617,
-0.003918463829904795,
-0.004600530490279198,
-0.005990470759570599,
-0.01163156796246767,
0.016680771484971046,
-0.004233446903526783,
-0.0029961189720779657,
-0.020987853407859802,
-0.019934015348553658,
-0.01579391583800316,
-0.01309735793620348,
-0.0037324074655771255,
0.010107669979333878,
0.0012680381769314408,
0.009516242891550064,
0.00893455184996128,
-0.008027160540223122,
-0.015038453042507172,
0.016045475378632545,
-0.006432187277823687,
0.012938611209392548,
-0.009470788761973381,
0.0012937081046402454,
0.012523695826530457,
-0.011014833115041256,
-0.006661293562501669,
0.005231022369116545,
0.0006838811095803976,
-0.023622624576091766,
0.00367184542119503,
0.009102344512939453,
-0.01711173728108406,
0.006082302890717983,
0.011477528139948845,
0.006787160411477089,
0.011017419397830963,
0.012728153727948666,
0.0006360250990837812,
-0.010819245129823685,
0.023930121213197708,
0.004694136790931225,
-0.009669063612818718,
0.01732354797422886,
0.007383954711258411,
0.012971822172403336,
-0.019161544740200043,
-0.0063856979832053185,
0.003658306784927845,
0.009715929627418518,
0.005891248118132353,
0.06711673736572266,
0.0058245533145964146,
0.00743476115167141,
-0.01313200406730175,
0.010206910781562328,
0.005597997456789017,
0.008449383080005646,
0.008053069934248924,
-0.011062253266572952,
-0.007019590586423874,
-0.0037520260084420443,
0.01107003539800644,
0.014251494780182838,
0.021127354353666306,
0.001789305591955781,
-0.007239018566906452,
0.0030320044606924057,
-0.01240890845656395,
-0.0057465266436338425,
0.0023688608780503273,
0.01365320011973381,
0.02717220038175583,
-0.01061085145920515,
0.024222437292337418,
-0.019431505352258682,
0.008700625039637089,
0.002424059435725212,
0.007006698753684759,
-0.016894005239009857,
0.02425091527402401,
0.03780720382928848,
-0.002425003331154585,
0.007087383884936571,
0.00544808991253376,
0.00022231542970985174,
0.007822633720934391,
-0.011686592362821102,
-0.000357035081833601,
0.011161012575030327,
0.008284772746264935,
-0.01294754259288311,
0.003571347799152136,
-0.000641966238617897,
-0.009350438602268696,
-0.00321843265555799,
-0.0018079301808029413,
-0.015343191102147102,
-0.01272206287831068,
0.008028574287891388,
0.007828356698155403,
-0.005271920934319496,
-0.0049257888458669186,
-0.0007326554041355848,
-0.0033613271079957485,
0.005902932491153479,
0.011222963221371174,
0.011694253422319889,
0.005695385858416557,
0.020544972270727158,
0.022456109523773193,
-0.0017137168906629086,
-0.003932458348572254,
-0.0400945283472538,
0.001031544990837574,
-0.00868622399866581,
0.021484991535544395,
0.005187928676605225,
0.008725013583898544,
-0.006754780653864145,
-0.0298208799213171,
-0.01740243099629879,
0.0029933503828942776,
-0.02218187041580677,
0.0015607886016368866,
0.005680624395608902,
0.027668196707963943,
0.021526921540498734,
-0.009688878431916237,
-0.0296860933303833,
0.02224811352789402,
-0.019350774586200714,
0.014110855758190155,
0.008308200165629387,
-0.003687131218612194,
0.012353457510471344,
-0.012204738333821297,
-0.008990194648504257,
0.002935451455414295,
-0.007524721324443817,
0.002173890359699726,
-0.0313107930123806,
0.009036299772560596,
-0.008731543086469173,
0.0027931276708841324,
-0.08161748945713043,
-0.009995860047638416,
-0.008219357579946518,
0.0048478394746780396,
0.0052163079380989075,
-0.008328971453011036,
-0.008546442724764347,
-0.012699112296104431,
-0.008282992988824844,
-0.02110210806131363,
0.0033868178725242615,
-0.01324097253382206,
0.0037654389161616564,
-0.009016843512654305,
-0.003375172847881913,
-0.0030944759491831064,
0.007674660533666611,
0.005467409733682871,
0.004328195005655289,
-0.014143932610750198,
0.0004112987080588937,
-0.003064344637095928,
0.032360173761844635,
-0.014194756746292114,
-0.018714280799031258,
-0.01939290761947632,
0.00419241189956665,
-0.008013938553631306,
-0.01768523082137108,
0.014701626263558865,
0.019428187981247902,
-0.014825072139501572,
-0.0034796549007296562,
-0.009034502319991589,
-0.02388768270611763,
0.022230669856071472,
0.0001905299723148346,
-0.019063033163547516,
0.002777476329356432,
0.012659680098295212,
0.013694076798856258,
0.003944297321140766,
0.0067588649690151215,
-0.005639607086777687,
0.01421661488711834,
0.013507036492228508,
-0.021767593920230865,
0.005887553095817566,
0.012546299025416374,
-0.016451101750135422,
0.00410798192024231,
-0.014001800678670406,
-0.0004134131595492363,
0.007941264659166336,
-0.015213070437312126,
-0.020983289927244186,
-0.017822833731770515,
-0.018397238105535507,
-0.010245862416923046,
-0.010574213229119778,
-0.029411165043711662,
-0.010726452805101871,
-0.010065359994769096,
0.027776522561907768,
0.01449088379740715,
-0.021396789699792862,
0.006910313852131367,
0.03428495675325394,
-0.0153213981539011,
0.009873757138848305,
0.033130254596471786,
-0.014981040731072426,
-0.005691211670637131,
-0.005329548381268978,
0.005437302403151989,
-0.010157644748687744,
-0.01303159724920988,
0.014532252214848995,
-0.006567446049302816,
0.020009556785225868,
-0.006253868341445923,
0.005607612896710634,
-0.010992920026183128,
0.016514256596565247,
-0.014736910350620747,
-0.027193717658519745,
0.006315214559435844,
0.013299981132149696,
0.007088041864335537,
-0.0167660191655159,
0.017076805233955383,
0.027587033808231354,
0.02128656581044197,
0.01350170187652111,
0.010756568983197212,
-0.01534496620297432,
0.0009158671018667519,
-0.021968994289636612,
-0.010761791840195656,
0.006463732570409775,
-0.01425359770655632,
-0.004371545277535915,
-0.0069764466024935246,
-0.012141019105911255,
0.016048839315772057,
0.013683073222637177,
0.011717712506651878,
0.012465985491871834,
-0.026909466832876205,
-0.009918127208948135,
0.0004650489427149296,
-0.0027395938523113728,
-0.007925738580524921,
0.004840471316128969,
0.01792021654546261,
0.01811666041612625,
-0.007174700032919645,
0.009076165035367012,
0.07271751016378403,
0.007288480643182993,
0.011940296739339828,
-0.006606473587453365,
0.003889898769557476,
-0.01537802629172802,
-0.005463007837533951,
-0.0043523069471120834,
0.02139449119567871,
0.00003225519321858883,
0.01012231782078743,
0.004669111222028732,
0.00753139890730381,
-0.012782255187630653,
0.01572340726852417,
0.013664561323821545,
-0.00015430105850100517,
-0.013158274814486504,
-0.009537752717733383,
0.011218741536140442,
0.002184792887419462,
0.00556013360619545,
-0.017472857609391212,
-0.01990671083331108,
0.025777127593755722,
-0.006091827526688576,
-0.005522079765796661,
-0.012061331421136856,
-0.014018364250659943,
0.0021546136122196913,
0.0032896301709115505,
0.01765807718038559,
-0.003199973376467824,
0.006842445116490126,
-0.005446846596896648,
0.010169485583901405,
-0.010434100404381752,
0.0006218445487320423,
0.009941737167537212,
0.0025896341539919376,
-0.011427592486143112,
-0.009950997307896614,
0.0029708240181207657,
-0.0025879761669784784,
-0.021965038031339645,
0.026035893708467484,
-0.009713957086205482,
-0.0026746399234980345,
0.0009411668870598078,
0.039873141795396805,
0.008394342847168446,
0.003018910065293312,
0.0024563316255807877,
-0.033402420580387115,
-0.005046646110713482,
0.012072356417775154,
-0.011330349370837212,
-0.0002117134863510728,
-0.013943091034889221,
-0.0075422246009111404,
-0.010426318272948265,
-0.007058743853121996,
0.02019851841032505,
-0.013757379725575447,
-0.01986735500395298,
-0.011600753292441368,
0.004263248294591904,
-0.016545843333005905,
-0.022332720458507538,
0.01644456945359707,
0.004652564413845539,
0.01280880719423294,
-0.005824739579111338,
-0.0054384870454669,
-0.0026611625216901302,
-0.035317353904247284,
-0.004007434938102961,
-0.0193919874727726,
0.0019878046587109566,
-0.032477036118507385,
-0.026818890124559402,
0.005353342276066542,
0.0070100100710988045,
-0.00796460174024105,
0.0038977661170065403,
0.016646359115839005,
-0.012830635532736778,
-0.0746081992983818,
0.010703254491090775,
0.035561252385377884,
-0.01473578903824091,
-0.027897581458091736,
0.01444309763610363,
-0.011012217029929161,
-0.007676195353269577,
0.004325119778513908,
0.0010915230959653854,
0.0057740299962460995,
0.001884054858237505,
-0.01619415357708931,
0.01598701998591423,
0.014787203632295132,
0.004662442021071911,
-0.0032908637076616287,
-0.0003442360321059823,
0.022279242053627968,
0.005675651133060455,
0.025017809122800827,
0.016168324276804924,
-0.005150295794010162,
-0.007270725443959236,
-0.00832143984735012,
-0.08149175345897675,
0.020265672355890274,
-0.0029365424998104572,
-0.02252034842967987,
-0.00063460657838732,
-0.0001120495144277811,
0.020738225430250168,
0.008161603473126888,
-0.011535998433828354,
-0.01295771449804306,
-0.010070530697703362,
-0.010496600531041622,
-0.004951091017574072,
-0.008021902292966843,
-0.012144206091761589,
-0.0015282484237104654,
-0.003913593012839556,
-0.005897758528590202,
-0.009790055453777313,
-0.0005209255032241344,
0.019870255142450333,
0.013161820359528065,
-0.0033168899826705456,
0.017403889447450638,
-0.006658700294792652,
-0.043476056307554245,
-0.022286683320999146,
0.004557155072689056,
0.015237419866025448,
-0.023658204823732376,
0.007398438639938831,
0.022490860894322395,
-0.0011651867534965277,
-0.015811190009117126,
-0.007998611778020859,
-0.004885256290435791,
-0.007824774831533432,
-0.002160810399800539,
0.000401222612708807,
0.0022633164189755917,
-0.008824053220450878,
-0.013911815360188484,
-0.015145075507462025,
-0.001531118992716074,
-0.004463483579456806,
0.004594950471073389,
0.007004224695265293,
-0.008189033716917038,
0.006791115738451481,
0.03185689076781273,
0.007417643908411264,
-0.011144444346427917,
0.020945031195878983,
-0.0008875997737050056,
-0.028138238936662674,
-0.019106805324554443,
-0.017430782318115234,
-0.013168162666261196,
0.012141370214521885,
0.01172601617872715,
-0.010166467167437077,
-0.009939216077327728,
0.009100871160626411,
0.07242675125598907,
-0.02021334506571293,
0.0018180159386247396,
-0.008177592419087887,
-0.01061711274087429,
-0.00011115364031866193,
-0.01761247217655182,
-0.007344843819737434,
0.015845978632569313,
0.00003026425838470459,
-0.02643365040421486,
-0.005237332079559565,
0.006118166260421276,
0.00682222843170166,
0.006243482232093811,
-0.035433679819107056,
0.005491858348250389,
0.012228727340698242,
-0.026173006743192673,
0.0065296366810798645,
0.023564374074339867,
0.016139131039381027,
-0.02618175558745861,
0.011465685442090034,
0.005572095513343811,
-0.007069671526551247,
-0.007142393384128809,
-0.012304507195949554,
0.00009021756704896688,
-0.0013968637213110924,
-0.006079350132495165,
-0.017582710832357407,
0.005429976619780064,
-0.020661264657974243,
0.01582641527056694,
-0.01570703834295273,
0.023217307403683662,
-0.00043468468356877565,
-0.034547414630651474,
-0.007042579352855682,
0.028097480535507202,
-0.025716420263051987,
0.00837279949337244,
-0.026058383285999298,
0.04155394434928894,
-0.03680180385708809,
-0.006902579218149185,
-0.025214888155460358,
0.0020299709867686033,
0.020232688635587692,
0.027881719172000885,
0.0012446832843124866,
0.00814390555024147,
0.009628666564822197,
-0.002728482009842992,
0.046866897493600845,
-0.0038592354394495487,
0.008909123949706554,
0.011552373878657818,
-0.01990155503153801,
0.006306794937700033,
-0.01673869788646698,
0.009805725887417793,
-0.02149844728410244,
-0.004627162590622902,
-0.005479598417878151,
0.02436605840921402,
-0.013681759126484394,
0.009435839019715786,
0.009051219560205936,
0.012347279116511345,
-0.013206026516854763,
0.006712672300636768,
0.009489727206528187,
-0.0026563131250441074,
-0.004100074991583824,
-0.0006221386138349771,
-0.009191229939460754,
0.01442922092974186,
-0.00039378926157951355,
-0.013991894200444221,
-0.02269606851041317,
0.032897546887397766,
-0.02170843817293644,
-0.024600204080343246,
0.009120985865592957,
0.021406512707471848,
-0.00803470890969038,
-0.011125972494482994,
0.00445434870198369,
-0.0036077676340937614,
0.013878315687179565,
-0.0008467935840599239,
0.0018870976055040956,
0.011633140966296196,
0.03336205706000328,
-0.004408381879329681,
0.004642785992473364,
0.02140653133392334,
0.0007178314263001084,
-0.0036682328209280968,
0.015614371746778488,
0.013010956346988678,
0.004248662851750851,
-0.004471274558454752,
0.000016588950529694557,
0.023552291095256805,
-0.009020444005727768,
-0.0004673453513532877,
-0.005116759333759546,
-0.002755560912191868,
0.00861264020204544,
0.006768262945115566,
0.022159863263368607,
-0.0005576235707849264,
0.011050224304199219,
-0.010135641321539879,
-0.02886717952787876,
-0.001419848995283246,
-0.016089238226413727,
0.0003069560043513775,
-0.011078756302595139,
0.0029679657891392708,
0.025450775399804115,
0.006166041828691959,
-0.0044870804995298386,
-0.004574337974190712,
-0.007575042080134153,
0.002230355516076088,
0.006867892108857632,
0.015425493940711021,
-0.0017498459201306105,
-0.012604912742972374,
-0.029950976371765137,
-0.0002442353870719671,
-0.025885291397571564,
-0.009520608000457287,
0.012168217450380325,
-0.002733685076236725,
-0.002759067341685295,
0.017884140834212303,
0.007826006971299648,
-0.004332033451646566,
0.003603951074182987,
0.00812181644141674,
0.004724996164441109,
0.00005842186510562897,
0.022238612174987793,
0.009437362663447857,
0.0029586246237158775,
-0.00001413421705365181,
0.011165564879775047,
0.009430859237909317,
-0.002223238116130233,
-0.017869915813207626,
0.009976129978895187,
0.013704393059015274,
0.0026008784770965576,
-0.011136248707771301,
-0.011153123341500759,
0.015019108541309834,
-0.040729641914367676,
0.020896587520837784,
0.013766516931355,
0.0013890194240957499,
0.015103779733181,
-0.007367154583334923,
-0.0055176252499222755,
-0.0025748014450073242,
0.02158500999212265,
0.014542126096785069,
0.009283835999667645,
-0.00024512119125574827,
0.013684697449207306,
-0.00678686099126935,
-0.004849917255342007,
-0.010718099772930145,
0.0014269916573539376,
-0.018850818276405334,
0.021679624915122986,
0.012136685661971569,
-0.018613599240779877,
-0.001036978093907237,
-0.008013027720153332,
-0.002305145375430584,
0.0078025395050644875,
-0.006935540121048689,
0.011025846004486084,
-0.00666585098952055,
-0.012199873104691505,
-0.012107365764677525,
-0.010078366845846176,
0.001960343448445201,
0.00625904044136405,
-0.008398220874369144,
0.0031774609815329313,
0.020927006378769875,
0.005557278636842966,
-0.0013834054116159678,
0.006278583314269781,
0.020380457863211632,
-0.020455315709114075
] | [
0.16282357275485992,
0.4194943606853485,
0.14327801764011383,
-0.15616552531719208,
-0.055580515414476395,
0.6656957864761353,
0.5370879173278809,
0.4195387065410614,
-0.48846250772476196,
0.33541446924209595,
0.05233636498451233,
-0.029872793704271317,
-0.10066423565149307,
0.15101492404937744,
-0.03295741602778435,
0.6420629620552063,
0.7291695475578308,
0.4496428668498993,
0.188065305352211,
-0.5787023305892944,
-0.22913511097431183,
-0.5090929865837097,
0.5244049429893494,
0.19499148428440094,
0.11172972619533539,
0.3211498260498047,
0.27635928988456726,
-0.14060457050800323,
-0.2811940908432007,
0.0897936299443245,
-0.5339502692222595,
0.9026349186897278,
0.3468732237815857,
-0.009210886433720589,
0.0033666209783405066,
-0.05425545945763588,
0.057023826986551285,
0.10019783675670624,
0.15050055086612701,
-0.01436280831694603,
-0.4987533688545227,
-0.1967519372701645,
-0.016590766608715057,
0.16322869062423706,
-0.17601129412651062,
-0.31108659505844116,
-0.7517586350440979,
0.363054484128952,
-0.21292680501937866,
0.19148969650268555,
-0.32067689299583435,
0.5736671090126038,
0.15635403990745544,
0.017215803265571594,
0.023977968841791153,
-0.07802918553352356,
0.05564761534333229,
0.12957753241062164,
-0.1846097856760025,
-0.050293706357479095,
0.356943279504776,
-0.054262783378362656,
0.3555040955543518,
0.1405658721923828,
-0.1580500304698944,
-0.1557367742061615,
0.01730646938085556,
0.48299992084503174,
0.07354529947042465,
0.05653451010584831,
0.09312010556459427,
0.10037021338939667,
-0.3745754361152649,
-0.12347407639026642,
-0.385982483625412,
0.0995897427201271,
-0.24777787923812866,
-0.15359902381896973,
0.28538456559181213,
-0.4127456545829773,
0.2753323018550873,
-0.11483711749315262,
0.7130826711654663,
-0.39635133743286133,
0.3436376452445984,
0.33870217204093933,
0.12745913863182068,
0.18885794281959534,
0.3263102173805237,
-0.3177991211414337,
-0.46520060300827026,
0.3974691331386566,
0.5256354808807373,
0.635446310043335,
-0.4898945689201355,
0.3362733721733093,
0.17656157910823822,
0.007320884149521589,
0.2673179507255554,
-0.17213529348373413,
0.22764137387275696,
0.4155918061733246,
0.4060900807380676,
-0.06932904571294785,
-0.4080771207809448,
0.036972202360630035,
0.37899643182754517,
0.05440400168299675,
-0.11853396147489548,
0.013198811560869217,
-0.7812921404838562,
0.1711125671863556,
-0.20457589626312256,
0.0025027459487318993,
0.03127431496977806,
0.4531131386756897,
0.10820687562227249,
-0.24132296442985535,
0.08223554491996765,
-0.0851212590932846,
-0.46966809034347534,
0.10078888386487961,
0.01189988199621439,
0.3293270766735077,
0.024281801655888557,
0.6414531469345093,
0.4142094552516937,
-0.004867468494921923,
0.19041652977466583,
0.2259054034948349,
-0.04658576473593712,
0.1269356608390808,
-0.16402104496955872,
0.36283206939697266,
0.10287369042634964,
-0.29376548528671265,
0.36765047907829285,
0.3520926535129547,
0.8369361758232117,
0.029064996168017387,
-0.5029569268226624,
-0.6164439916610718,
-0.4729774296283722,
-0.30086567997932434,
0.16685320436954498,
-0.42698755860328674,
0.012541582807898521,
-0.38331180810928345,
-0.4015052020549774,
-0.17875425517559052,
0.3205966353416443,
0.12717890739440918,
-0.3893681466579437,
-0.5964687466621399,
0.3341980278491974,
0.40481916069984436,
-0.4636324942111969,
-0.02204066328704357,
-0.6032761931419373,
-0.46111437678337097,
0.7507044076919556,
0.7715455293655396,
-0.07908935844898224,
-0.1746794879436493,
0.48225241899490356,
-0.0478782057762146,
-0.3492354154586792,
-0.08378700166940689,
-0.012159904465079308,
0.024807851761579514,
-0.1938633769750595,
0.1999422311782837,
0.03676299378275871,
-0.25906479358673096,
-0.8228539824485779,
0.4786508083343506,
0.3482602834701538,
0.4789053797721863,
0.03849444538354874,
0.045425817370414734,
-0.48489832878112793,
0.06762480735778809,
0.5706565380096436,
-0.495389848947525,
-0.1151585727930069,
-0.217372328042984,
0.4718315005302429,
0.09412169456481934,
-0.0029842909425497055,
-0.07967724651098251,
0.07968993484973907,
-0.5297080874443054,
0.7495331764221191,
-0.5306950807571411,
1.037072777748108,
-0.636838972568512,
-0.1019972413778305,
0.7095695734024048,
0.30623289942741394,
-0.2052040696144104,
-0.014819464646279812,
0.27334704995155334,
0.4968433678150177,
-0.21518874168395996,
-0.8873370289802551,
-0.27401110529899597,
-0.5074736475944519,
0.07955338060855865,
-0.03140351548790932,
-0.23815126717090607,
-0.2686220109462738,
-0.6561151146888733,
-0.4348766803741455,
0.10189783573150635,
-0.059833332896232605,
0.36569833755493164,
-0.14313872158527374,
0.3278075158596039,
0.5195131301879883,
-0.5465342402458191,
0.32980847358703613,
-0.3716297745704651,
0.1841661036014557,
0.014894038438796997,
-0.22226129472255707,
0.5194100737571716,
0.6049820780754089,
0.028613438829779625,
0.39913657307624817,
-0.9372279047966003,
0.5778210163116455,
0.2999671399593353,
0.039637159556150436,
-0.32667648792266846,
0.021425873041152954,
0.22189724445343018,
-0.2137434184551239,
-0.1625497192144394,
-0.4910987317562103,
-0.148897185921669,
0.19641929864883423,
-0.17534849047660828,
-0.25750288367271423,
-0.18310175836086273,
0.26793476939201355,
-0.33926284313201904,
-0.0938630998134613,
0.21042613685131073,
-0.520763635635376,
0.5094683766365051,
0.1448281705379486,
0.16202597320079803,
0.08811400085687637,
0.07230645418167114,
-0.15885350108146667,
0.21896852552890778,
0.11934641748666763,
-0.5779293179512024,
-0.042000893503427505,
-0.1787792146205902,
0.16668254137039185,
-0.11894510686397552,
0.1498393565416336,
0.3047400712966919,
0.40357640385627747,
-0.9607040286064148,
-0.5696337223052979,
-0.48186105489730835,
0.38054752349853516,
0.48257526755332947,
0.633556067943573,
-0.05320913717150688,
-0.36348193883895874,
0.34368571639060974,
0.12814629077911377,
-0.47879713773727417,
0.23010782897472382,
0.10738963633775711,
-0.44894126057624817,
-0.2110474854707718,
0.024240892380475998,
0.36580345034599304,
0.6751111745834351,
-0.06241529807448387,
0.1205187514424324,
-0.6183215975761414,
0.03756900876760483,
0.24419939517974854,
0.038807474076747894,
0.010834462009370327,
-0.0030020158737897873,
0.33893275260925293,
-0.004779013805091381,
-0.6000506281852722,
0.371887743473053,
0.11162088066339493,
-0.10176899284124374,
0.40293756127357483,
0.38352999091148376,
0.023289266973733902,
0.14131048321723938,
0.09749133139848709,
-0.17698293924331665,
0.06784221529960632,
0.07771263271570206,
0.3903605341911316,
-0.2518271207809448,
-0.27064257860183716,
-6.092160224914551,
0.44449320435523987,
-0.9415936470031738,
-1.0223374366760254,
-0.2659580111503601,
0.1431555300951004,
0.8829872012138367,
-0.13956612348556519,
0.07219119369983673,
0.15137997269630432,
0.11457160115242004,
0.22218775749206543,
0.226711243391037,
0.7355687022209167,
0.47789183259010315,
0.3404523432254791,
0.5450141429901123,
-0.43800023198127747,
0.1393754482269287,
0.2771165072917938,
0.109405517578125,
-0.6161685585975647,
-0.07180164754390717,
0.26580679416656494,
-0.07755504548549652,
0.6619681715965271,
-0.5672582387924194,
0.060651544481515884,
-0.20753523707389832,
-0.3319673240184784,
0.37480980157852173,
-0.6873846054077148,
-0.41487687826156616,
-0.14966988563537598,
0.19557668268680573,
-0.176454558968544,
0.14144748449325562,
0.20384946465492249,
-0.22031649947166443,
-0.4971774220466614,
0.009002715349197388,
0.22986648976802826,
-0.22404253482818604,
-0.12034626305103302,
0.6531783938407898,
0.26601842045783997,
-0.2464503049850464,
0.030396291986107826,
-0.749567985534668,
0.3576807677745819,
0.03084912709891796,
0.005125492811203003,
-0.015974627807736397,
0.5781505107879639,
-0.15283320844173431,
-0.10969465970993042,
-0.09809514135122299,
0.5939181447029114,
-0.05223507061600685,
0.26568907499313354,
0.46521100401878357,
-0.021530527621507645,
0.009711997583508492,
-0.5184122920036316,
-0.49601343274116516,
0.33684229850769043,
-0.8285323977470398,
-0.17779508233070374,
0.20016638934612274,
0.06465351581573486,
0.10227084159851074,
-0.5035314559936523,
0.00913205649703741,
-0.38563215732574463,
0.07112026959657669,
-0.4425797462463379,
0.41188809275627136,
0.37977463006973267,
0.09448802471160889,
-0.14644190669059753,
-0.1279514580965042,
-0.07170931249856949,
0.5874815583229065,
-0.4523475766181946,
-0.10165408253669739,
0.15536966919898987,
-0.39200326800346375,
0.0662887766957283,
-0.060664936900138855,
-0.3574211001396179,
0.5876624584197998,
-0.35138121247291565,
0.12848781049251556,
0.35043057799339294,
0.30238795280456543,
0.7272739410400391,
0.5563861131668091,
0.15805096924304962,
0.3316192030906677,
-0.31751635670661926,
0.4305592477321625,
-0.1855262815952301,
-0.16324302554130554,
-1.0256751775741577,
-0.2002590447664261,
-0.21865074336528778,
-0.327914834022522,
-0.10809002071619034,
0.45488297939300537,
-0.7050166130065918,
0.25153085589408875,
0.02745930291712284,
-0.18088562786579132,
-0.35976091027259827,
0.6559972167015076,
-0.24261623620986938,
0.03853743523359299,
0.005671019200235605,
0.33243727684020996,
-0.23591136932373047,
0.00016719983250368387,
-0.1688450574874878,
-0.39045003056526184,
0.46802324056625366,
-0.1901075690984726,
-0.7181866765022278,
0.027515994384884834,
0.3008533716201782,
-0.6110462546348572,
-0.01807292364537716,
0.3249162435531616,
0.6030619740486145,
0.1463678777217865,
0.2764723002910614,
0.16206054389476776,
-0.18185044825077057,
-0.32137545943260193,
0.03212565928697586,
0.4695436656475067,
0.20015409588813782,
0.38666030764579773,
-0.062292154878377914,
-0.4515368640422821,
0.3756392002105713,
0.09391631931066513,
-0.10231737047433853,
-0.45289650559425354,
-0.13766084611415863,
-0.13343651592731476,
-0.12281633913516998,
0.10134474188089371,
-0.14156608283519745,
0.2454371452331543,
0.2211746871471405,
-0.3889467120170593,
-0.003982130438089371,
0.4249328076839447,
0.10848712176084518,
-0.7466728687286377,
-0.4256206452846527,
0.18077689409255981,
-0.2730969488620758,
-1.0074350833892822,
-0.013421105220913887,
-0.35540077090263367,
-0.29749128222465515,
0.36503294110298157,
-0.1839647889137268,
0.3848782479763031,
0.5111825466156006,
-0.05191201716661453,
-0.4895300269126892,
0.23062320053577423,
0.16444900631904602,
0.3525502383708954,
-0.208550363779068,
-0.4057300388813019,
-0.2335125207901001,
-0.4015839695930481,
-0.12337802350521088,
-0.16397404670715332,
-0.17005568742752075,
-0.5413002967834473,
0.041780538856983185,
0.4344565272331238,
0.8225783109664917,
-0.2026129812002182,
-0.0657963752746582,
0.3239075541496277,
-0.1576029509305954,
0.17626315355300903,
-0.5491148829460144,
0.10822323709726334,
0.027019741013646126,
-0.2460109442472458,
-0.6291327476501465,
0.34458473324775696,
0.37783846259117126,
-0.2992117404937744,
0.11783113330602646,
-0.10357250273227692,
0.015689577907323837,
-0.4465935528278351,
0.195839986205101,
0.7707186341285706,
-0.42677006125450134,
-0.22621653974056244,
-0.08529508858919144,
-0.6487435102462769,
-0.5970973372459412,
-0.24801936745643616,
-0.09473828971385956,
-0.6484352946281433,
0.41300126910209656,
-0.20002268254756927,
0.21453829109668732,
0.039433106780052185,
-0.532229483127594,
-0.29202044010162354,
0.26590269804000854,
0.39109817147254944,
0.04916401207447052,
-0.5493445992469788,
0.2537271976470947,
-0.1570274531841278,
0.021987859159708023,
0.7030659914016724,
-0.8495598435401917,
-0.023428162559866905,
0.26005738973617554,
-0.6397287845611572,
0.3610116243362427,
0.16093720495700836,
0.2692369818687439,
-0.2697655260562897,
-0.2924271821975708,
-0.5401164889335632,
-0.07282126694917679,
0.18400512635707855,
0.7945848107337952,
-0.6649690270423889,
0.634749710559845,
0.15292268991470337,
-0.654132068157196,
0.2109844982624054,
-0.29251667857170105,
0.11374958604574203,
-0.5708855390548706,
-0.04441595822572708,
0.13742172718048096,
0.20954950153827667,
-0.7518777251243591,
0.23801402747631073,
-0.10754463076591492,
0.34464412927627563,
0.36979973316192627,
-0.1025352030992508,
-0.3106814920902252,
0.16957105696201324,
0.2718540132045746,
-0.3364197313785553,
-0.16255491971969604,
0.08976861834526062,
0.1691589653491974,
0.41035565733909607,
-0.17259928584098816,
-0.2886512577533722,
-0.3101891577243805,
0.3058478534221649,
-0.39894309639930725,
0.13275422155857086,
0.06709687411785126,
0.27899640798568726,
0.47633764147758484,
0.5861137509346008,
-0.3207421600818634,
-0.05908144265413284,
0.08029128611087799,
0.10897835344076157,
0.3482685387134552,
-0.5809524655342102,
-0.3760747015476227,
0.17837479710578918,
-0.09548605978488922,
0.23477329313755035,
-0.27007871866226196,
0.38947492837905884,
-0.34990841150283813,
-0.7433555722236633,
-0.2644893527030945,
0.1655629277229309,
0.5609490275382996,
-0.35516223311424255,
-0.2026491016149521,
-0.03920743241906166,
0.3058546781539917,
0.8845618367195129,
0.8467892408370972,
0.18401825428009033,
0.02968485653400421,
0.28352707624435425,
0.1447685956954956,
0.1661633402109146,
-0.2852575480937958,
-0.16047199070453644,
-0.09975454211235046,
0.23193322122097015,
-0.2548777461051941,
-0.2781843841075897,
0.013348505832254887,
0.35743460059165955,
0.005436226259917021,
0.7235992550849915,
0.5152314901351929,
-0.7724372744560242,
-0.1183992400765419,
-0.25251713395118713,
-0.4992559254169464,
0.9409814476966858,
0.08684525638818741,
-0.09200167655944824,
0.4430742859840393,
0.40412887930870056,
0.09006692469120026,
0.288232684135437,
0.3265383243560791,
0.23506556451320648,
0.49987971782684326,
-0.006171181332319975,
0.08821247518062592,
0.18242676556110382,
0.3992422819137573,
0.3093798756599426,
0.18457229435443878,
-0.4486386477947235,
0.26017096638679504,
-0.07636571675539017,
-0.7814866900444031,
-0.3710746467113495,
0.06793036311864853,
0.8073710799217224,
0.3432137370109558,
0.027991361916065216,
-0.13871009647846222,
0.5613157749176025,
0.29719555377960205,
-0.2547928988933563,
-0.2945725619792938,
-0.06064702942967415,
0.2013179212808609,
0.0665699765086174,
-0.12447954714298248,
0.2783544063568115,
0.032112810760736465,
0.058870408684015274,
0.12968182563781738,
-0.17338179051876068,
0.11486084014177322,
-0.6852888464927673,
0.125291109085083,
-0.2701221704483032,
0.35601571202278137,
-0.161383718252182,
0.27261751890182495,
-0.37484416365623474,
-0.3283585011959076,
0.34330499172210693,
0.30837056040763855,
-0.33194708824157715,
-0.1222086176276207,
-0.19328515231609344,
0.006107470020651817,
-0.7474324107170105,
-0.02915281243622303,
-0.1130710318684578,
-0.5870220065116882,
0.12223797291517258,
0.16257698833942413,
0.4144333004951477,
0.4140149652957916,
-0.2219027876853943,
-0.12528447806835175,
0.08769840747117996,
-0.6916196346282959,
0.3911439776420593,
0.0038444979581981897,
-0.22241732478141785,
0.2688125967979431,
0.30453574657440186,
0.12195946276187897,
0.3628828823566437,
-0.34673386812210083,
0.3717619776725769,
-0.24320253729820251,
-0.3484477400779724,
-0.18336611986160278,
-0.07375224679708481,
0.3296448290348053,
0.54360431432724,
-0.2303401678800583,
-0.2534642517566681,
-0.16773252189159393,
-0.23338808119297028,
0.19459986686706543,
0.06811510026454926,
0.7296303510665894,
-0.4201640486717224,
-0.5064066052436829,
-0.1460382491350174,
0.23744137585163116,
0.15075618028640747,
0.2350776642560959,
-0.2359638214111328,
0.020097753033041954,
-0.011609858833253384,
0.05647750571370125,
0.4613344669342041,
-0.23498466610908508,
-0.17311464250087738,
-0.2711179852485657,
-0.4125095307826996,
-0.4562219977378845,
0.36682069301605225,
-0.23796483874320984,
-0.25409823656082153,
0.3226524889469147,
0.20968106389045715,
-0.18243728578090668,
0.0607655830681324,
0.6719573736190796,
-0.04454253986477852,
-0.5315934419631958,
-0.37107953429222107,
0.1986502856016159,
-0.5188397169113159,
0.05798768252134323,
0.4756566882133484,
0.16564524173736572,
0.5685856938362122,
-0.4882006049156189,
-0.666659951210022,
-0.2892530560493469,
0.03614666312932968,
-0.36746200919151306,
0.3616700768470764,
0.5354090332984924,
-0.0862201526761055,
-0.357287734746933,
-1.0310652256011963,
0.0023409079294651747,
-0.6510511040687561,
-0.39925965666770935,
-0.5594536662101746,
0.05101242661476135,
-0.12800049781799316,
-0.6504709720611572,
-0.1410386860370636,
-0.5291305184364319,
-0.08407307416200638,
-0.3522992432117462
] |
Although the etiology of multiple sclerosis (MS) remains enigmatic, the role of T cells is unquestionably central in this pathology. Immune cells respond to pathogens and danger signals via pattern-recognition receptors (PRR). Several reports implicate Nlrp12, an intracellular PRR, in the development of a mouse MS-like disease, called Experimental Autoimmune Encephalomyelitis (EAE). In this study, we used induced and spontaneous models of EAE, as well as in vitro T cell assays, to test the hypothesis that Nlrp12 inhibits Th1 response and prevents T-cell mediated autoimmunity. We found that Nlrp12 plays a protective role in induced EAE by reducing IFNγ/IL-4 ratio in lymph nodes, whereas it potentiates the development of spontaneous EAE (spEAE) in 2D2 T cell receptor (TCR) transgenic mice. Looking into the mechanism of Nlrp12 activity in T cell response, we found that it inhibits T cell proliferation and suppresses Th1 response by reducing IFNγ and IL-2 production. Following TCR activation, Nlrp12 inhibits Akt and NF-κB phosphorylation, while it has no effect on S6 phosphorylation in the mTOR pathway. In conclusion, we propose a model that can explain the dual immunoregulatory function of Nlrp12 in EAE. We also propose a model explaining the molecular mechanism of Nlrp12-dependent regulation of T cell response. | [
0.0007631229236721992,
-0.003970275167375803,
-0.013670068234205246,
0.0008573883678764105,
0.0059285471215844154,
0.027628403156995773,
0.009357962757349014,
0.013489422388374805,
-0.010938306339085102,
-0.02201944589614868,
-0.012354361824691296,
0.004867632873356342,
0.0006368664326146245,
0.02201310358941555,
0.006977297365665436,
0.005373694002628326,
-0.009857130236923695,
0.010134687647223473,
0.01654498279094696,
0.015106886625289917,
-0.008632121607661247,
-0.0006324439309537411,
0.011298343539237976,
-0.006201582960784435,
0.01696103811264038,
0.008985215798020363,
0.03344005346298218,
-0.025799915194511414,
-0.029792241752147675,
-0.0017548101022839546,
0.017104528844356537,
0.011712603271007538,
-0.0028546799439936876,
0.011510888114571571,
-0.005865063518285751,
-0.02389281615614891,
-0.0020526587031781673,
0.0225696861743927,
0.01965015009045601,
-0.004318939987570047,
0.019570985808968544,
-0.008043240755796432,
0.003929439932107925,
-0.043325528502464294,
-0.006528743542730808,
0.0038318904116749763,
0.0002849914599210024,
-0.0019483738578855991,
-0.014655489474534988,
0.008144032210111618,
-0.0052805934101343155,
-0.020265638828277588,
-0.01571854203939438,
-0.011768938973546028,
-0.006863963324576616,
0.008518055081367493,
0.018937941640615463,
0.008708784356713295,
0.014087582007050514,
0.01706727407872677,
-0.01212994009256363,
-0.008377907797694206,
0.011494986712932587,
0.0004416313022375107,
-0.019644036889076233,
-0.06667099893093109,
0.026408381760120392,
-0.0012971698306500912,
-0.005888276733458042,
0.01413519773632288,
-0.01057506538927555,
0.009971651248633862,
-0.0012432672083377838,
-0.0002894718199968338,
-0.024494759738445282,
-0.027551796287298203,
-0.01831786334514618,
0.03640769422054291,
-0.0012441002763807774,
0.0013063549995422363,
0.016301486641168594,
-0.00781067181378603,
-0.0013707720208913088,
0.0026674435939639807,
-0.0035567781887948513,
0.019555311650037766,
-0.029415491968393326,
-0.002761390060186386,
-0.010793060064315796,
-0.031242817640304565,
-0.04437196999788284,
0.03047678992152214,
-0.02398538962006569,
-0.00849898997694254,
-0.031448207795619965,
-0.01175844669342041,
-0.03079150803387165,
0.0159527026116848,
-0.007141013164073229,
-0.03504300117492676,
-0.021980464458465576,
-0.013836806640028954,
0.026774343103170395,
0.03790063410997391,
0.011778749525547028,
0.00834912434220314,
0.010446154512465,
0.019753966480493546,
0.04324008524417877,
0.013180133886635303,
-0.004010665230453014,
0.0014215537812560797,
-0.03403965383768082,
0.00854974053800106,
0.025756048038601875,
-0.00018267735140398145,
0.019923491403460503,
-0.002152055501937866,
0.01652030274271965,
-0.005472986027598381,
-0.016174770891666412,
0.003813601564615965,
-0.010568330064415932,
-0.003327838843688369,
0.0011846127454191446,
-0.0370766818523407,
0.009896162897348404,
0.018746603280305862,
-0.01331477053463459,
0.0020283947233110666,
-0.008744364604353905,
0.004984801635146141,
0.013871612027287483,
-0.0026796841993927956,
-0.0019850863609462976,
-0.00503063527867198,
0.00007958803325891495,
-0.015398832969367504,
0.0036460552364587784,
-0.027134327217936516,
-0.0073093692772090435,
0.011325683444738388,
0.0006334965582937002,
0.010141348466277122,
-0.011722343042492867,
-0.00018268986605107784,
-0.005993936210870743,
0.008789179846644402,
0.019868144765496254,
-0.012288989499211311,
0.0204345490783453,
0.0013290930073708296,
0.0005121987778693438,
-0.012957793660461903,
-0.0019519808702170849,
0.0274122916162014,
-0.018724102526903152,
-0.015575301833450794,
-0.0016742153093218803,
0.02558363415300846,
-0.01672726683318615,
-0.009437017142772675,
0.016991790384054184,
0.011248419061303139,
0.01868567243218422,
-0.002448352752253413,
-0.0029540499672293663,
-0.027328576892614365,
0.005697578191757202,
0.009918365627527237,
-0.000037687597796320915,
-0.01849171333014965,
0.014199499040842056,
0.010487262159585953,
-0.002472559455782175,
-0.0086985994130373,
0.0159932691603899,
0.008415350690484047,
-0.02325507625937462,
0.06603207439184189,
-0.0019026382360607386,
-0.015354013070464134,
0.013793171383440495,
0.018374990671873093,
-0.0008844984695315361,
-0.01765340194106102,
0.021769901737570763,
-0.0033499172423034906,
-0.02566494047641754,
-0.004860229790210724,
-0.027228066697716713,
-0.0037232907488942146,
-0.01413063332438469,
-0.035032615065574646,
-0.023976320400834084,
0.002338872756808996,
0.0034322869032621384,
0.005882278550416231,
0.0034522470086812973,
-0.005736947059631348,
0.006356377620249987,
-0.023356955498456955,
0.024799074977636337,
0.0065579162910580635,
0.0018636691384017467,
0.007603614591062069,
-0.007522988133132458,
-0.027366995811462402,
-0.017961004748940468,
0.0035285477060824633,
0.018254276365041733,
-0.03111964464187622,
-0.016441263258457184,
-0.007653546519577503,
-0.0013156193308532238,
-0.002254846040159464,
0.01379118300974369,
-0.0120540801435709,
0.003727738745510578,
-0.016466738656163216,
-0.007008440792560577,
0.007796349935233593,
-0.01855389028787613,
-0.008425921201705933,
0.015345871448516846,
-0.022512532770633698,
-0.010071467608213425,
0.010796517133712769,
-0.0012361087137833238,
-0.0116178710013628,
-0.0319933220744133,
-0.03711315244436264,
-0.012327645905315876,
0.003808992449194193,
0.018206721171736717,
0.0014966423623263836,
0.014338442124426365,
-0.008166098035871983,
0.019230423495173454,
-0.018252121284604073,
-0.001660522073507309,
-0.0018961522728204727,
0.025036659091711044,
-0.011184640228748322,
0.03271915763616562,
0.009272446855902672,
0.0043154023587703705,
-0.00040345429442822933,
0.009793447330594063,
-0.025564908981323242,
0.010165460407733917,
-0.022072523832321167,
0.0009758956730365753,
0.013430817052721977,
0.016780834645032883,
-0.020936859771609306,
0.008861731737852097,
-0.008042939007282257,
0.023986011743545532,
0.00995488092303276,
0.003716397797688842,
0.006527051795274019,
0.00003268592990934849,
0.01405707560479641,
-0.019627947360277176,
0.021737104281783104,
-0.012584855780005455,
0.039995137602090836,
0.013393697328865528,
-0.017748232930898666,
0.013124159537255764,
-0.002471859799697995,
0.0030649122782051563,
-0.08111610263586044,
-0.006826789118349552,
0.004046009853482246,
0.007866823114454746,
0.004290481097996235,
-0.03430800512433052,
0.012586573138833046,
-0.0013429573737084866,
-0.012068694457411766,
0.0208639744669199,
-0.005110134370625019,
-0.00829211063683033,
-0.013069214299321175,
0.02139401249587536,
-0.03199513629078865,
-0.005975144915282726,
0.011360406875610352,
-0.012053195387125015,
0.003313307184726,
-0.052706487476825714,
0.0003641936928033829,
-0.01185867004096508,
0.01707412861287594,
0.024015061557292938,
-0.018223758786916733,
0.011797387152910233,
0.01260723453015089,
0.01404321938753128,
0.022007402032613754,
-0.0027190844994038343,
-0.03272053226828575,
0.005173292476683855,
0.0199916772544384,
0.0013910054694861174,
-0.012170383706688881,
0.004278333391994238,
-0.0011823764070868492,
-0.028679627925157547,
-0.005997108295559883,
0.04391169920563698,
-0.0004521748051047325,
0.012627438642084599,
0.0005583073943853378,
-0.004665045533329248,
0.01812828704714775,
0.013216372579336166,
0.02501603774726391,
-0.002739854156970978,
0.01634996011853218,
-0.008755521848797798,
0.009193784557282925,
0.004407308530062437,
-0.004270539153367281,
0.021996689960360527,
-0.0037900260649621487,
-0.02655610628426075,
-0.04010270535945892,
-0.0033744063694030046,
-0.009927788749337196,
-0.00419933907687664,
-0.00404736865311861,
-0.015512274578213692,
0.021513964980840683,
0.03376168757677078,
-0.005676515866070986,
0.018082883208990097,
0.014136161655187607,
0.002387516899034381,
-0.025440622121095657,
0.011755401268601418,
0.004507264122366905,
0.006089669652283192,
-0.00895334780216217,
-0.011526226997375488,
-0.03412367030978203,
-0.00660640187561512,
-0.01378991361707449,
-0.0012884261086583138,
0.00269519560970366,
-0.012658004648983479,
-0.016243645921349525,
0.0016768514178693295,
-0.026752671226859093,
-0.0031697445083409548,
-0.02564254403114319,
-0.02149057202041149,
0.008362757973372936,
0.038081564009189606,
0.01760290563106537,
-0.015181394293904305,
0.03363068401813507,
0.02250407636165619,
-0.006364515982568264,
0.014937036670744419,
-0.015856614336371422,
-0.002033601514995098,
-0.018540196120738983,
0.000528811477124691,
0.002350766211748123,
0.008926711045205593,
-0.03264027088880539,
-0.002245896263048053,
-0.008631817996501923,
-0.001578188268467784,
-0.018849823623895645,
0.01665744185447693,
-0.007607306353747845,
0.013937924057245255,
-0.0018215500749647617,
-0.003895922563970089,
-0.005577682517468929,
-0.0033669904805719852,
-0.0034447673242539167,
0.013783853501081467,
0.015278510749340057,
-0.004049189854413271,
-0.0067343018017709255,
-0.037886012345552444,
0.0722818598151207,
-0.028502095490694046,
-0.0035693019162863493,
-0.015823835507035255,
0.02458079718053341,
-0.030017374083399773,
-0.03840125352144241,
0.027851207181811333,
-0.005319567397236824,
0.02474294602870941,
0.011766105890274048,
-0.022878900170326233,
0.009363684803247452,
-0.009815848432481289,
-0.0273274015635252,
-0.014217548072338104,
-0.004987660795450211,
-0.01004630234092474,
0.009779459796845913,
0.018117379397153854,
0.032815370708703995,
-0.005038045346736908,
-0.01854844018816948,
0.019959814846515656,
0.016695449128746986,
-0.012729620561003685,
-0.015383001416921616,
-0.010613820515573025,
0.0013162163086235523,
0.011921667493879795,
-0.018934153020381927,
-0.0033230003900825977,
-0.009313886985182762,
0.0036190208047628403,
0.03383517265319824,
0.005331569351255894,
0.006758051458746195,
-0.002096788492053747,
-0.0058194417506456375,
-0.006396787706762552,
-0.030113380402326584,
-0.01654025912284851,
0.023635178804397583,
0.014600807800889015,
-0.016367781907320023,
-0.004089781083166599,
0.033259641379117966,
-0.007614237256348133,
-0.01193123497068882,
-0.02605118602514267,
-0.015030103735625744,
0.02343156188726425,
0.012790078297257423,
0.012648394331336021,
0.0065750060603022575,
-0.008225410245358944,
0.008215867914259434,
0.00478316517546773,
0.007845845073461533,
-0.021274195984005928,
-0.013645808212459087,
0.01842844858765602,
0.021984819322824478,
-0.011146124452352524,
0.013489151373505592,
-0.022423015907406807,
-0.0008233487606048584,
0.007825436070561409,
-0.013486390933394432,
-0.01735955849289894,
0.0234210267663002,
-0.028672408312559128,
-0.01785665936768055,
0.0077015613205730915,
-0.022689051926136017,
-0.006186393555253744,
-0.01710137352347374,
-0.018522130325436592,
0.014506678096950054,
0.02480199933052063,
-0.02131260558962822,
0.00872556958347559,
0.005113408900797367,
-0.001630665734410286,
0.008746721781790257,
0.013314072974026203,
-0.018381372094154358,
-0.07446902990341187,
-0.01647237129509449,
-0.014550641179084778,
-0.010328416712582111,
-0.003122358350083232,
0.015700405463576317,
-0.025563109666109085,
0.004151335917413235,
0.018802650272846222,
-0.0034098741598427296,
0.026013685390353203,
0.011298442259430885,
-0.02212747000157833,
0.004151099361479282,
0.013217776082456112,
-0.001733141951262951,
0.010310790501534939,
-0.01322165597230196,
0.002984224818646908,
0.01050623320043087,
0.024390749633312225,
-0.01694619283080101,
-0.050613656640052795,
0.016624759882688522,
-0.007052823901176453,
-0.08123713731765747,
0.005935216788202524,
-0.01754181459546089,
-0.03635489195585251,
-0.00011902890400961041,
0.0029077883809804916,
0.01631346344947815,
-0.01104733720421791,
-0.026998396962881088,
-0.01885594055056572,
-0.012124339118599892,
0.0010793192777782679,
-0.029426613822579384,
-0.018866315484046936,
0.0033953008241951466,
-0.0067940885201096535,
0.024124914780259132,
-0.01606670580804348,
0.0018087527714669704,
-0.013228120282292366,
-0.0019398527219891548,
-0.005712113343179226,
-0.007470604032278061,
-0.008927160874009132,
-0.012871859595179558,
-0.024806581437587738,
-0.0023656892590224743,
0.012520013377070427,
0.006934401113539934,
0.019942179322242737,
-0.01971031352877617,
0.005307808052748442,
-0.025257544592022896,
-0.01016307808458805,
0.0011951811611652374,
-0.014692718163132668,
-0.008454516530036926,
-0.0057637616991996765,
-0.0016772402450442314,
-0.020704062655568123,
-0.006312474608421326,
0.011962084099650383,
-0.023969311267137527,
0.024877263233065605,
-0.02126242034137249,
-0.021972961723804474,
0.008137363009154797,
-0.0037477605510503054,
0.017474176362156868,
-0.016184745356440544,
0.002390751149505377,
-0.014152675867080688,
0.023394010961055756,
-0.011494841426610947,
0.005369782447814941,
0.03052636608481407,
-0.001741547486744821,
-0.0002443576231598854,
0.001036597415804863,
0.004642665386199951,
-0.0099226338788867,
0.0062403446063399315,
0.009802840650081635,
0.0711747407913208,
-0.03542516380548477,
0.013281765393912792,
-0.009661702439188957,
0.01652887649834156,
0.004176688846200705,
-0.06251004338264465,
-0.015869952738285065,
-0.031061362475156784,
-0.02074071392416954,
0.004777922295033932,
-0.008787855505943298,
0.007399781607091427,
0.014199990779161453,
-0.021264877170324326,
-0.00837450660765171,
0.0022097467444837093,
-0.006858201697468758,
0.010725212283432484,
0.014597664587199688,
-0.004750604275614023,
0.002543678041547537,
-0.04195135086774826,
-0.017453858628869057,
0.05692451819777489,
0.01666160300374031,
-0.01955767348408699,
0.016373105347156525,
-0.04936257004737854,
0.01728290319442749,
0.00028745969757437706,
-0.014026693068444729,
0.002120689721778035,
0.003921312279999256,
0.025454705581068993,
0.016101479530334473,
0.00048676133155822754,
0.009388575330376625,
0.0012148157693445683,
0.041428543627262115,
0.004988947417587042,
0.00957898236811161,
-0.004880359396338463,
-0.006182669661939144,
0.03291759267449379,
-0.003443970810621977,
0.007145634852349758,
-0.012666000984609127,
0.005235591903328896,
0.005341571290045977,
-0.003050378989428282,
0.0030170155223459005,
0.038224056363105774,
-0.017737887799739838,
0.0007376266294158995,
0.038626208901405334,
0.00942043773829937,
0.019195128232240677,
0.0014650942757725716,
-0.003673917381092906,
0.009911195375025272,
-0.010264318436384201,
0.007063527591526508,
-0.026789911091327667,
0.0015198386972770095,
0.00044019101187586784,
0.008037891238927841,
-0.01849464327096939,
-0.036943014711141586,
0.018920820206403732,
-0.002731484128162265,
0.021723289042711258,
0.010512995533645153,
0.011402212083339691,
0.037986040115356445,
0.019757770001888275,
0.01588275097310543,
0.003392485436052084,
0.009378832764923573,
0.026586921885609627,
-0.01736941561102867,
0.006383143365383148,
0.02606787160038948,
0.0067655174061656,
-0.012422079220414162,
0.009383190423250198,
-0.018305055797100067,
-0.011869663372635841,
-0.002215912099927664,
0.010948555544018745,
0.01016276329755783,
0.011469518765807152,
0.011102921329438686,
0.013098081573843956,
0.010603935457766056,
0.033183082938194275,
-0.01302446611225605,
0.00514743197709322,
0.012792330235242844,
0.01598714478313923,
0.006093982141464949,
0.008052081800997257,
-0.00767045421525836,
0.03323954716324806,
-0.0011312607675790787,
0.0125025175511837,
0.01208605244755745,
0.012272380292415619,
-0.008752727881073952,
0.01832585409283638,
-0.003136095590889454,
-0.03154454752802849,
0.021307900547981262,
0.013466058298945427,
-0.009488791227340698,
-0.02045232057571411,
-0.0076079051941633224,
0.014328761026263237,
0.009738026186823845,
-0.014254026114940643,
0.021292798221111298,
0.011256805621087551,
-0.013772401958703995,
0.02615218795835972,
0.009747333824634552,
-0.03217008709907532,
-0.013423234224319458,
0.009602371603250504,
0.00856614951044321,
0.006113640498369932,
0.0318467952311039,
0.01232467032968998,
-0.054596446454524994,
-0.011097125709056854,
0.010798802599310875,
0.01818719133734703,
0.026506206020712852,
-0.020699582993984222,
-0.014433193951845169,
-0.029348626732826233,
0.03410085663199425,
-0.032481249421834946,
-0.005245703738182783,
-0.027489185333251953,
0.008585711941123009,
-0.02137168124318123,
0.015821510925889015,
-0.020258137956261635,
0.00985817238688469,
0.023817747831344604,
0.0032768938690423965,
-0.003481099847704172,
-0.0023434488102793694,
-0.006852871738374233,
0.04521559923887253,
0.031330548226833344,
0.008716682903468609,
-0.0011123490985482931,
-0.033611834049224854,
0.01254015602171421,
-0.016977088525891304,
-0.0003371525090187788,
0.04529770463705063,
-0.006015302613377571,
-0.0032974304631352425,
-0.01348634622991085,
0.001587435370311141,
0.008528998121619225,
0.004473340697586536,
-0.020803622901439667,
0.04235615208745003,
-0.02614220231771469,
0.004180952440947294,
0.008392173796892166,
-0.014475935138761997,
-0.0036629047244787216,
-0.0007262285798788071,
0.0002673789858818054,
0.019851168617606163,
0.013087188825011253,
0.00008542125578969717,
-0.015801483765244484,
0.009720364585518837,
-0.016024580225348473,
0.008281479589641094,
-0.020961061120033264,
-0.00876525603234768,
0.004835723899304867,
-0.002100976649671793,
-0.0037003718316555023,
-0.020480331033468246,
-0.029197078198194504,
-0.006423667073249817,
0.010033722035586834,
-0.015830237418413162,
0.01310775987803936,
0.028321826830506325,
-0.030690710991621017,
-0.005609611514955759,
-0.002612883923575282,
-0.0017583654262125492,
-0.013641316443681717
] | [
0.10640254616737366,
-0.2323000282049179,
-0.1301799863576889,
0.0529034286737442,
-0.12089786678552628,
0.05167622119188309,
0.33809685707092285,
-0.16442571580410004,
-0.5090991258621216,
-0.19031654298305511,
0.3641415238380432,
0.031845252960920334,
-0.3443165123462677,
0.1106041818857193,
-0.06521826982498169,
0.5188783407211304,
0.47916650772094727,
0.21984227001667023,
-0.0657755434513092,
-0.24951212108135223,
-0.4115860164165497,
-0.5004657506942749,
0.27673086524009705,
-0.08674313127994537,
-0.013108370825648308,
-0.003834841540083289,
0.6130349636077881,
-0.03885546326637268,
0.5045000314712524,
-0.06105504930019379,
-0.17984548211097717,
0.537451446056366,
0.014238370582461357,
-0.5038558840751648,
-0.4185531437397003,
0.13140147924423218,
-0.6539574265480042,
-0.18232765793800354,
-0.089168980717659,
0.09301561117172241,
-0.3492276966571808,
-0.37367603182792664,
-0.6811263561248779,
0.42631077766418457,
-0.013529207557439804,
-0.16030530631542206,
-1.53475821018219,
1.1409553289413452,
0.21101266145706177,
0.2975829541683197,
-0.2442932277917862,
0.348519891500473,
-0.12740784883499146,
0.21117188036441803,
0.4450252652168274,
0.31952717900276184,
-0.7070046663284302,
-0.05236417427659035,
0.21594713628292084,
-0.5241154432296753,
-0.01696157455444336,
-0.022334234789013863,
-0.2243451625108719,
0.31427332758903503,
-0.15041550993919373,
0.8986126780509949,
-0.20069673657417297,
-0.11276071518659592,
-0.6359538435935974,
-0.23851275444030762,
0.36869922280311584,
-0.3883656859397888,
-0.2212313860654831,
0.1411391943693161,
-0.07850824296474457,
0.07466781139373779,
-0.3419404923915863,
-0.6182767152786255,
0.19154107570648193,
0.1261598765850067,
-0.11082854866981506,
-0.04509782791137695,
0.4841890037059784,
0.33686551451683044,
0.44856590032577515,
0.16386115550994873,
0.010995842516422272,
0.5082803964614868,
-0.09923075139522552,
-0.4876687228679657,
0.018563218414783478,
-0.10801932960748672,
0.8109506368637085,
0.12716279923915863,
0.08288145810365677,
0.5041535496711731,
0.04070308431982994,
-0.1327982246875763,
-0.3573233485221863,
0.05494174361228943,
-0.2695329487323761,
0.026978787034749985,
-0.13531340658664703,
-0.5303453803062439,
-0.5408827662467957,
-0.07781379669904709,
0.07813063263893127,
-0.6676473021507263,
-0.41325825452804565,
0.016294162720441818,
-0.6326355934143066,
-0.06208605691790581,
-0.41580867767333984,
-0.3878803551197052,
-0.13724678754806519,
-0.12201600521802902,
0.5197766423225403,
-0.2957663834095001,
0.45486369729042053,
0.058144401758909225,
-0.054626233875751495,
1.011970043182373,
-0.24846094846725464,
0.6678948998451233,
-0.1303023099899292,
-0.17269015312194824,
0.2514573633670807,
0.12548556923866272,
0.2871556282043457,
0.4028708040714264,
-0.100316621363163,
0.8335722088813782,
-0.26072800159454346,
-0.1651739925146103,
0.1253282129764557,
0.3137829601764679,
-0.058290909975767136,
0.18778321146965027,
0.1784183233976364,
0.23562459647655487,
-0.4039604067802429,
-0.458151638507843,
-0.05696306377649307,
-0.34801048040390015,
-0.2665383517742157,
-0.14849774539470673,
-0.10077212750911713,
0.2462540715932846,
0.14974525570869446,
-0.44794291257858276,
-0.044442880898714066,
-0.44183313846588135,
-0.2588748633861542,
-0.0051839170046150684,
0.13028039038181305,
0.48770689964294434,
0.055896561592817307,
-0.20218756794929504,
0.045952510088682175,
0.3616876006126404,
0.32190150022506714,
-0.30294787883758545,
-0.32890909910202026,
-0.004354056902229786,
0.43792665004730225,
0.22999422252178192,
0.14612744748592377,
0.5341628789901733,
-0.07043591141700745,
-0.45430833101272583,
-0.4812098741531372,
-0.45620784163475037,
0.28086504340171814,
-0.7992790341377258,
0.21559680998325348,
-0.12675777077674866,
0.13860277831554413,
-0.04543919861316681,
-0.034900497645139694,
-0.18145149946212769,
-0.9486463069915771,
-0.48665452003479004,
-0.5677403807640076,
-0.5158495306968689,
0.6045196652412415,
0.28918635845184326,
0.3491937816143036,
0.06550890952348709,
-0.07114356756210327,
0.22257734835147858,
-0.05142350494861603,
-0.20107142627239227,
0.7900898456573486,
-0.28931447863578796,
1.4968116283416748,
-0.2557011544704437,
-0.35454750061035156,
1.6218124628067017,
0.6598358154296875,
0.2076384425163269,
-0.11166396737098694,
-0.30248361825942993,
0.3570973575115204,
-0.2762742042541504,
-0.3633480370044708,
-0.08844028413295746,
-0.08723343163728714,
-0.03793088719248772,
-0.054157331585884094,
0.06010615453124046,
0.22031055390834808,
-0.6645125150680542,
-0.4060669243335724,
-0.024603459984064102,
0.18332813680171967,
-0.20024961233139038,
0.03938921168446541,
-0.06456167995929718,
-0.4754553735256195,
-0.04099973291158676,
0.307717502117157,
-0.9490906596183777,
0.47685641050338745,
0.7978816628456116,
-0.21287287771701813,
0.710178017616272,
0.412161260843277,
0.28543031215667725,
1.2281873226165771,
-0.8540935516357422,
0.28693002462387085,
-0.6300458312034607,
0.2904095947742462,
-0.7565881609916687,
-0.49206066131591797,
0.2536815404891968,
0.17446637153625488,
-0.1918301284313202,
0.2724199593067169,
-0.2761228680610657,
-0.1859084516763687,
0.9742777347564697,
-0.46890151500701904,
-0.037014417350292206,
-0.004969730973243713,
-0.3464062213897705,
-0.605185329914093,
0.13931693136692047,
-0.6158190369606018,
0.18675972521305084,
-0.21112972497940063,
0.26211825013160706,
-0.10257774591445923,
-0.5570634603500366,
0.0017371708527207375,
0.3025659918785095,
0.024825137108564377,
-0.41779080033302307,
0.2300845831632614,
-0.5955518484115601,
-0.21103422343730927,
0.0028264145366847515,
-0.05879228562116623,
0.4531233012676239,
-0.041280753910541534,
-0.6647899746894836,
-0.7963736057281494,
-0.11942748725414276,
1.3095686435699463,
0.6683014631271362,
1.1387660503387451,
-0.15933509171009064,
-0.4500785768032074,
-0.07799088954925537,
0.34022924304008484,
-0.6627699732780457,
-0.1404632031917572,
0.7716196775436401,
-0.214029923081398,
-0.26897749304771423,
-0.3178675174713135,
0.39528247714042664,
1.0111535787582397,
-0.2166973203420639,
-0.5198630690574646,
0.22852586209774017,
-0.1940947324037552,
-0.09521371871232986,
-0.28499674797058105,
-0.18770451843738556,
-0.004290523007512093,
0.17656725645065308,
-0.10851001739501953,
0.10489965975284576,
0.37762728333473206,
-0.12686505913734436,
-0.03114260360598564,
0.4343419075012207,
0.48266586661338806,
0.09296070784330368,
-0.562061071395874,
0.350082129240036,
-0.5127236247062683,
-0.3491031229496002,
-0.25444674491882324,
0.4017540216445923,
-0.39268386363983154,
0.3932064473628998,
-5.6548027992248535,
-0.1425718069076538,
-0.18399594724178314,
-0.3514649569988251,
-0.11513864248991013,
-0.18433928489685059,
1.137946605682373,
0.07233171164989471,
0.23440319299697876,
0.4265196919441223,
0.6483469605445862,
0.5721625089645386,
0.07125750929117203,
-0.08479169011116028,
-0.47342219948768616,
-0.16293473541736603,
-0.3536936938762665,
-0.5646214485168457,
0.8381134271621704,
0.09547724574804306,
0.03190341591835022,
-0.11473588645458221,
-0.07522346824407578,
0.5390289425849915,
-0.1490054577589035,
0.12473376095294952,
-0.8658177256584167,
-0.19414348900318146,
0.1123286634683609,
-0.26885268092155457,
0.1720981001853943,
-0.568420946598053,
-0.171329528093338,
0.20234546065330505,
0.10142955183982849,
-0.2728981077671051,
0.24226202070713043,
-0.5637736916542053,
-0.28762030601501465,
-0.3502579927444458,
0.24033518135547638,
0.08060348778963089,
-0.08212339133024216,
-0.19092851877212524,
-0.1300218403339386,
-0.26962003111839294,
-0.06418152898550034,
-0.014893505722284317,
-0.5154016017913818,
0.5441252589225769,
0.06364567577838898,
-0.11252347379922867,
0.6047772765159607,
0.4592646360397339,
0.5476204752922058,
-0.034591399133205414,
-0.0509602427482605,
-0.2755078673362732,
-0.6878423094749451,
0.06545837223529816,
-0.36658617854118347,
0.14117386937141418,
-0.37863340973854065,
-0.6680449843406677,
0.3447137773036957,
0.28212133049964905,
-0.5736556649208069,
-0.5696462392807007,
0.536909818649292,
-0.5003897547721863,
-0.045326657593250275,
0.27593377232551575,
-0.05445759743452072,
-0.8499147891998291,
0.6371576189994812,
-0.0976279005408287,
0.24874064326286316,
0.06119391694664955,
0.26465582847595215,
-0.6999065279960632,
-0.6128768920898438,
-0.2553657293319702,
-0.21586444973945618,
-0.16881728172302246,
0.19535696506500244,
-0.3005829155445099,
0.008620775304734707,
0.24017542600631714,
-0.0566718727350235,
0.4533880650997162,
0.6976755857467651,
0.0624132975935936,
0.04648418724536896,
0.8575965762138367,
-0.38233253359794617,
0.3317294120788574,
0.38234177231788635,
0.6538968086242676,
0.6385084390640259,
0.036727044731378555,
0.7028927803039551,
-0.29434826970100403,
-0.3567793369293213,
-0.9580669403076172,
-0.3689820170402527,
0.42011675238609314,
-0.5455321073532104,
-0.25922831892967224,
0.8874292373657227,
-0.9555317163467407,
0.11347071081399918,
-0.15627814829349518,
-0.428779274225235,
0.08516738563776016,
0.9680187702178955,
-0.36581072211265564,
0.06228334829211235,
0.31598344445228577,
0.7124767303466797,
-0.4157985746860504,
0.38498589396476746,
0.85676509141922,
-0.7830484509468079,
0.6587610244750977,
0.22707678377628326,
0.10534506291151047,
0.02082003653049469,
0.6407562494277954,
-0.7064853310585022,
-0.46544307470321655,
0.192610964179039,
0.1875409483909607,
-0.13827335834503174,
0.29904335737228394,
0.3796151280403137,
-0.23836521804332733,
-0.5252861380577087,
0.3994980454444885,
0.47166556119918823,
0.13737645745277405,
0.3410685062408447,
-0.029796095564961433,
0.1387542486190796,
0.30106794834136963,
0.3411320447921753,
-0.2266453504562378,
0.08653634041547775,
0.1724015474319458,
-0.49887171387672424,
-0.2549487054347992,
0.17934097349643707,
-0.4016362726688385,
-0.04017091915011406,
0.001202674931846559,
-0.11977267265319824,
0.6687580347061157,
0.47645604610443115,
0.12189516425132751,
0.2668358087539673,
-0.31775781512260437,
-0.12988634407520294,
0.48371562361717224,
-1.121120572090149,
-0.2262720763683319,
0.05108766630291939,
-0.5948173403739929,
-0.04076210409402847,
-0.5890563726425171,
-0.002247103489935398,
0.2290439009666443,
-0.709916353225708,
-0.22891861200332642,
0.09819214046001434,
0.08224222809076309,
0.2827763855457306,
-0.3237331509590149,
-0.5042133331298828,
-0.038045212626457214,
-0.2910185754299164,
0.6272798776626587,
0.1767849326133728,
-0.21781539916992188,
-0.4516156315803528,
0.18787811696529388,
0.5685128569602966,
0.33442792296409607,
-0.04137677326798439,
-0.1896144598722458,
-0.10658057034015656,
-0.33633172512054443,
0.224846750497818,
0.10859706252813339,
-0.050976596772670746,
-0.03489866480231285,
-0.37085822224617004,
0.24601690471172333,
0.05862954631447792,
0.14381174743175507,
0.14426687359809875,
-0.4963805079460144,
0.17530745267868042,
0.4411059617996216,
-0.23603585362434387,
0.452579528093338,
0.5399685502052307,
-0.26632294058799744,
-0.1352769434452057,
0.3116588294506073,
-0.25201770663261414,
0.029020188376307487,
0.17215342819690704,
-0.40581756830215454,
0.22696952521800995,
0.386756032705307,
0.11517472565174103,
-0.1581222414970398,
0.27417054772377014,
-0.30523043870925903,
-0.1311338096857071,
0.4121302366256714,
0.09404933452606201,
-0.07196125388145447,
0.07294707000255585,
-0.009076355956494808,
-0.4895925521850586,
-0.00770697183907032,
0.5178094506263733,
-0.9846455454826355,
0.6133999824523926,
0.4130145013332367,
0.016711097210645676,
-0.192744180560112,
0.01827329955995083,
0.1315520852804184,
-0.41153207421302795,
-0.801878809928894,
-0.3227124512195587,
0.3559914231300354,
0.32120585441589355,
0.5048918128013611,
0.34070900082588196,
0.07632799446582794,
-0.4797719419002533,
0.15888549387454987,
0.010144665837287903,
-0.08495212346315384,
0.37561914324760437,
-0.5960831046104431,
-0.11242016404867172,
0.1593957543373108,
0.5027913451194763,
-0.06065789610147476,
0.028407372534275055,
0.5659647583961487,
1.2867408990859985,
0.24691352248191833,
0.040963951498270035,
-0.3212187588214874,
-0.3315623998641968,
-0.02760128304362297,
-0.33183547854423523,
-0.011181382462382317,
-0.1247771829366684,
-0.038140539079904556,
-0.13922792673110962,
0.17849890887737274,
-0.02591182477772236,
-0.8161607384681702,
0.5557368397712708,
-0.14506042003631592,
-0.16180144250392914,
0.03273661062121391,
0.9499061703681946,
0.34448158740997314,
-0.3074119985103607,
0.22425994277000427,
-0.4199574291706085,
0.16266633570194244,
-0.14757958054542542,
0.46025457978248596,
0.1620001494884491,
-0.5426988005638123,
0.5393410325050354,
-0.42481470108032227,
0.4294945001602173,
-0.6490507125854492,
0.28984665870666504,
-0.755330502986908,
0.3722112476825714,
-0.5040298104286194,
-0.5787320733070374,
0.22147144377231598,
-0.5068148374557495,
-0.40169408917427063,
-0.06863869726657867,
-0.04560404270887375,
-0.09807723760604858,
0.40247103571891785,
-0.09241767972707748,
0.13819053769111633,
-0.9151692986488342,
0.27911901473999023,
0.5857899188995361,
0.09616025537252426,
-0.5719925165176392,
0.3340907692909241,
0.34518423676490784,
-0.043774571269750595,
-0.5321042537689209,
0.1902529001235962,
-0.1597733348608017,
-0.43523603677749634,
0.7259043455123901,
-0.12405522167682648,
-0.6867097616195679,
0.24266444146633148,
0.14829251170158386,
-0.18642736971378326,
0.09327759593725204,
0.1637536883354187,
0.10231734812259674,
0.7420542240142822,
0.5068007111549377,
-0.09198164939880371,
-0.2504037022590637,
0.7932313084602356,
0.08675117790699005,
0.36850669980049133,
0.23504005372524261,
0.7066991329193115,
0.5826578736305237,
0.07237964123487473,
-0.02721078135073185,
0.8200763463973999,
0.4119415879249573,
0.2827525734901428,
0.42119672894477844,
-0.33767396211624146,
-0.3014823794364929,
-0.22616656124591827,
0.6177978515625,
0.18930071592330933,
-0.10066846758127213,
-0.3740469217300415,
0.25370854139328003,
0.2981504499912262,
0.3453831374645233,
0.32787877321243286,
-0.0016240670811384916,
-0.053320594131946564,
0.37264764308929443,
-0.3846272826194763,
-0.21183039247989655,
0.25282999873161316,
-0.35079655051231384,
0.3046506941318512,
0.5313316583633423,
-0.3362751603126526,
-0.3955661654472351,
0.336076945066452,
-0.6087456941604614,
-0.03305963799357414,
0.2911090552806854,
0.7669206857681274,
-0.2699136435985565,
0.03212451562285423,
0.6395158767700195,
0.2461492419242859,
0.4534549415111542,
-0.043485671281814575,
-0.15190058946609497,
-0.14326754212379456,
-0.26292940974235535,
0.2912655472755432,
0.1504804790019989,
-0.6627567410469055,
0.5107806921005249,
-0.46791142225265503,
-0.1638590544462204,
0.5405426025390625,
-0.2809620499610901,
0.1570550501346588,
-0.31593552231788635,
-0.8981786370277405,
-0.1253049075603485,
-0.5246151089668274,
-0.33512595295906067,
-0.20231197774410248,
-0.19638660550117493,
-0.21580365300178528,
0.2144308239221573,
-0.6132597327232361,
0.3106059432029724,
0.298147588968277,
0.15858560800552368,
0.24983085691928864,
-0.06856078654527664,
0.03772691637277603,
0.17749133706092834,
0.5772643089294434,
0.0031021772883832455,
0.1708306074142456,
0.0468786247074604,
0.36943939328193665,
-1.091395616531372,
0.3416578769683838,
-0.18965676426887512,
-0.35394033789634705,
-0.493321031332016,
-0.25450295209884644,
1.0031743049621582,
0.7744481563568115,
-0.19404442608356476,
-0.07947007566690445,
0.06588826328516006,
0.06485381722450256,
0.37514764070510864,
-0.5978602766990662,
-0.03428724780678749,
-0.36198097467422485,
-0.09528592973947525,
-0.5934002995491028,
0.917365312576294,
-0.10049346089363098,
-0.6171255707740784,
-0.1507922261953354,
0.7132110595703125,
0.05631616711616516,
-0.12545979022979736,
0.21599048376083374,
-0.533262312412262,
-0.02592938393354416,
-0.7173876762390137,
0.21238113939762115,
-0.5644989609718323,
-0.5110660195350647,
-0.307176798582077,
0.05702400207519531,
0.17238257825374603,
-0.30764490365982056,
0.3525734841823578,
-0.1564459651708603,
-0.07108819484710693,
0.02693704515695572,
0.2234184890985489,
0.40124452114105225,
-0.6025092005729675,
-0.6203804016113281,
-0.4420817196369171,
-0.0808672159910202,
-0.09508494287729263,
-0.32897695899009705,
-0.16997650265693665,
-0.13858242332935333,
0.07367710024118423,
0.09575027227401733,
0.1189282089471817,
-0.28875958919525146,
-0.13062512874603271,
0.17698949575424194
] |
KEY POINTS The vascular endothelial growth factor (VEGF) responses to acute submaximal exercise and training effects in patients with heart failure with reduced ejection fraction (HFrEF) were investigated. Six patients and six healthy matched controls performed knee-extensor exercise (KE) at 50% of maximum work rate before and after (only patients) KE training. Muscle biopsies were taken to assess skeletal muscle structure and the angiogenic response. Before training, during this submaximal KE exercise, patients with HFrEF exhibited higher leg vascular resistance and greater noradrenaline spillover. Skeletal muscle structure and VEGF response were generally not different between groups. Following training, resistance was no longer elevated and noradrenaline spillover was curtailed in the patients. Although, in the trained state, VEGF did not respond to acute exercise, capillarity was augmented. Muscle fibre cross-sectional area and percentage area of type I fibres increased and mitochondrial volume density exceeded that of controls. Structural/functional plasticity and appropriate angiogenic signalling were observed in skeletal muscle of patients with HFrEF. ABSTRACT This study examined the response to acute submaximal exercise and the effect of training in patients with heart failure with reduced ejection fraction (HFrEF). The acute angiogenic response to submaximal exercise in HFrEF after small muscle mass training is debated. The direct Fick method, with vascular pressures, was performed across the leg during knee-extensor exercise (KE) at 50% of maximum work rate (WRmax ) in patients (n = 6) and controls (n = 6) and then after KE training in patients. Muscle biopsies facilitated the assessment of skeletal muscle structure and vascular endothelial growth factor (VEGF) mRNA levels. Prior to training, HFrEF exhibited significantly higher leg vascular resistance (LVR) (≈15%) and significantly greater noradrenaline spillover (≈385%). Apart from mitochondrial volume density, which was significantly lower (≈22%) in HFrEF, initial skeletal muscle structure, including capillarity, was not different between groups. Resting VEGF mRNA levels, and the increase with exercise, was not different between patients and controls. Following training, LVR was no longer elevated and noradrenaline spillover was curtailed. Skeletal muscle capillarity increased with training, as assessed by capillary-to-fibre ratio (≈13%) and number of capillaries around a fibre (NCAF ) (≈19%). VEGF mRNA was now not significantly increased by acute exercise. Muscle fibre cross-sectional area and percentage area of type I fibres both increased significantly with training (≈18% and ≈21%, respectively), while the percentage area of type II fibres fell significantly (≈11%), and mitochondrial volume density now exceeded that of controls. These data reveal structural and functional plasticity and appropriate angiogenic signalling in skeletal muscle of HFrEF patients. | [
0.0052810125052928925,
0.01282482873648405,
-0.00958422850817442,
0.015137884765863419,
0.010559022426605225,
0.012009285390377045,
0.011807207018136978,
-0.01087972428649664,
-0.009920753538608551,
-0.0015030577778816223,
-0.010175267234444618,
0.026087632402777672,
-0.020507819950580597,
0.00633933674544096,
-0.024545226246118546,
0.025917649269104004,
0.0021965154446661472,
0.029354864731431007,
0.014124705456197262,
0.012251948937773705,
0.008574527688324451,
0.014920827932655811,
0.010199370793998241,
-0.02888050489127636,
-0.03733094036579132,
-0.005437775515019894,
0.014150990173220634,
-0.0035624601878225803,
0.03448716551065445,
-0.03291665017604828,
0.0023499364033341408,
-0.027918150648474693,
-0.015643738210201263,
0.0007413653656840324,
0.019251223653554916,
0.00003423972520977259,
-0.009337195195257664,
0.015743998810648918,
0.002998142968863249,
-0.005424116738140583,
-0.015106715261936188,
-0.010359726846218109,
0.009305019862949848,
-0.007242093328386545,
-0.008030871860682964,
0.005791335832327604,
-0.0050392914563417435,
-0.004543955437839031,
0.009601477533578873,
0.007450202479958534,
-0.013072515837848186,
-0.04637262970209122,
-0.00999191589653492,
0.00812166091054678,
-0.00651191920042038,
0.003154125064611435,
0.017418693751096725,
-0.008610360324382782,
-0.03771892189979553,
-0.02709108591079712,
-0.015175270847976208,
0.003665860975161195,
0.02298189327120781,
-0.01579601876437664,
-0.023521577939391136,
-0.06656567752361298,
0.02449306845664978,
0.006993849296122789,
0.006401775870472193,
-0.005361124873161316,
-0.02996504120528698,
0.014221428893506527,
0.022882483899593353,
-0.019168654456734657,
0.0066634067334234715,
-0.01687351055443287,
-0.008037962019443512,
0.02083405666053295,
0.020441055297851562,
-0.0010398933663964272,
0.0073754312470555305,
-0.0048918104730546474,
0.013060510158538818,
0.011061900295317173,
-0.0036630015820264816,
0.016241518780589104,
-0.009426858276128769,
-0.012408165261149406,
0.0024014459922909737,
-0.005439978092908859,
-0.007635122165083885,
0.007047033403068781,
0.02365896664559841,
0.013533770106732845,
0.0060410210862755775,
0.039255499839782715,
-0.0068741487339138985,
-0.03437894582748413,
-0.009546629153192043,
-0.02439103089272976,
-0.021627310663461685,
-0.005802920088171959,
0.02046206220984459,
-0.0068331132642924786,
-0.0008634442929178476,
0.0068157631903886795,
0.025380395352840424,
0.02744217962026596,
0.0064217643812298775,
0.008120373822748661,
0.0024454528465867043,
0.012738190591335297,
0.0029742512851953506,
-0.003487874288111925,
0.010990754701197147,
0.024837559089064598,
-0.019754476845264435,
0.019557788968086243,
0.011307974345982075,
-0.01748352125287056,
0.03357532247900963,
0.0019309381023049355,
-0.006202787160873413,
-0.02196650579571724,
0.0010642664274200797,
-0.03211412951350212,
-0.00028503313660621643,
-0.009930511005222797,
-0.05045811086893082,
0.0016277690883725882,
-0.007999913766980171,
0.003468774724751711,
0.03803953155875206,
-0.012483315542340279,
-0.00654861843213439,
-0.014254679903388023,
0.014915567822754383,
-0.010556422173976898,
-0.01794757880270481,
-0.002439540810883045,
0.0045314147137105465,
0.0043177418410778046,
0.005644509568810463,
0.01730608567595482,
0.007670661900192499,
-0.012675984762609005,
0.01679648458957672,
0.008297696709632874,
0.013942484743893147,
-0.014203043654561043,
0.02760864794254303,
-0.006357632577419281,
-0.007775617763400078,
-0.025226514786481857,
-0.01697458326816559,
0.01958658918738365,
-0.026828661561012268,
-0.005121411755681038,
0.011815758422017097,
0.009048844687640667,
-0.07254606485366821,
-0.012048924341797829,
0.018340373411774635,
0.008097527548670769,
-0.013796459883451462,
0.006070375442504883,
-0.005099402740597725,
-0.015960421413183212,
-0.006782375741750002,
0.005695168860256672,
-0.0023192132357507944,
-0.00121902150567621,
-0.009508108720183372,
0.007751633413136005,
0.003703553695231676,
-0.009129518643021584,
0.008978374302387238,
0.010720081627368927,
-0.016458218917250633,
0.0660245418548584,
-0.005934529472142458,
-0.011220540851354599,
-0.012118188664317131,
0.04690151661634445,
-0.019694020971655846,
-0.027424996718764305,
0.027263104915618896,
-0.010771806351840496,
0.01938953995704651,
-0.010128042660653591,
0.011151706799864769,
-0.0010505053214728832,
0.026220858097076416,
-0.004578280728310347,
-0.014801363460719585,
0.0038952280301600695,
0.021550336852669716,
0.005465892609208822,
-0.005364816635847092,
-0.003390355035662651,
0.013296433724462986,
-0.02513662539422512,
0.025477906689047813,
-0.017313353717327118,
-0.006087286397814751,
0.022661959752440453,
0.013331552967429161,
0.004504581913352013,
0.0235280804336071,
0.006003980990499258,
-0.013451529666781425,
-0.00531174149364233,
-0.006619564723223448,
-0.027127468958497047,
0.013699148781597614,
0.003169686533510685,
0.002952484879642725,
0.011505644768476486,
0.0036996412090957165,
-0.011340169236063957,
0.010445162653923035,
-0.0014923717826604843,
-0.036933399736881256,
-0.015311450697481632,
0.0034123286604881287,
0.010656598024070263,
-0.0034323169384151697,
0.011171255260705948,
-0.023481883108615875,
0.009354360401630402,
-0.013563089072704315,
-0.007091875188052654,
-0.012456543743610382,
0.014773123897612095,
0.010789460502564907,
0.00803200900554657,
0.012924101203680038,
-0.015027894638478756,
0.015469037927687168,
-0.01680127903819084,
0.000801311805844307,
0.0122119365260005,
-0.005425327457487583,
-0.008867591619491577,
-0.000590271782130003,
0.011614999733865261,
0.017180059105157852,
-0.011098179034888744,
0.019131483510136604,
-0.00804622657597065,
0.010780176147818565,
0.013802873902022839,
-0.016551362350583076,
0.0016471706330776215,
0.027633393183350563,
-0.037825778126716614,
0.026428593322634697,
0.02454719878733158,
0.026015155017375946,
-0.00681548984721303,
-0.004363628104329109,
0.00913769006729126,
-0.02239801734685898,
0.019856197759509087,
-0.006460162345319986,
0.012211651541292667,
0.0003554094582796097,
0.021014852449297905,
0.015253645367920399,
0.01686522550880909,
0.00853689480572939,
-0.011540910229086876,
-0.018924709409475327,
-0.08161120861768723,
-0.010284049436450005,
-0.01247204840183258,
0.015469471924006939,
0.0020899646915495396,
0.025315362960100174,
0.004162357654422522,
0.0029295114800333977,
-0.024973317980766296,
-0.004372819326817989,
-0.007837135344743729,
-0.02605358511209488,
0.0005911565385758877,
0.010171282105147839,
-0.015210548415780067,
-0.012513522990047932,
0.011382514610886574,
0.023470094427466393,
-0.02198702096939087,
-0.0008083884604275227,
-0.004654389340430498,
-0.002848770935088396,
-0.007271378301084042,
-0.001535644754767418,
-0.017735283821821213,
0.006424522493034601,
-0.013110814616084099,
-0.02643214538693428,
0.012491155415773392,
0.019247110933065414,
-0.02647283487021923,
0.0041280584409832954,
0.025755232200026512,
0.008274847641587257,
0.0006005857139825821,
0.006682452280074358,
-0.011193388141691685,
-0.009873474016785622,
-0.01656545326113701,
0.009272279217839241,
-0.012619545683264732,
0.007178682833909988,
-0.00468813069164753,
-0.0009136581793427467,
-0.008357569575309753,
-0.006610970012843609,
0.022868072614073753,
-0.001382024260237813,
0.02123316191136837,
0.015606705099344254,
-0.007887021638453007,
-0.005721298046410084,
-0.014540869742631912,
0.017999496310949326,
-0.021895790472626686,
-0.012695899233222008,
-0.008405645377933979,
0.006413317751139402,
-0.013930213637650013,
-0.025701291859149933,
-0.015662632882595062,
0.0098934480920434,
0.023760218173265457,
-0.02445957250893116,
0.03184115141630173,
-0.002818387933075428,
0.010118022561073303,
-0.005807355046272278,
-0.028623003512620926,
0.029083868488669395,
0.013724484480917454,
-0.009233992546796799,
-0.02302641049027443,
-0.009078025817871094,
-0.02179379016160965,
-0.022271443158388138,
-0.018211737275123596,
0.001328786602243781,
0.039245232939720154,
0.0025280627887696028,
-0.024294383823871613,
0.00785907357931137,
0.0038230475038290024,
0.005722240544855595,
-0.027316542342305183,
-0.029709262773394585,
0.010862655937671661,
0.030091069638729095,
0.023708220571279526,
-0.01814255304634571,
-0.032759878784418106,
0.025478608906269073,
-0.020307326689362526,
0.01086061354726553,
-0.007662893272936344,
-0.012338273227214813,
0.0064046261832118034,
-0.009341861121356487,
0.0011505591683089733,
0.009421978145837784,
-0.022458413615822792,
0.0027840600814670324,
0.03747014328837395,
-0.008587283082306385,
-0.03358955308794975,
0.015477020293474197,
0.0006643017986789346,
0.010062497109174728,
-0.007811328396201134,
-0.0025533654261380434,
-0.020792577415704727,
-0.02044384926557541,
-0.008617243729531765,
-0.028385687619447708,
0.01437737513333559,
-0.007024104706943035,
0.016934894025325775,
0.02278023585677147,
0.07231427729129791,
-0.006984893232584,
0.01609799638390541,
-0.0010576257482171059,
0.02864118665456772,
-0.028646402060985565,
0.02820146270096302,
0.0021877489052712917,
0.034745071083307266,
0.004325967747718096,
0.013033387251198292,
0.010417671874165535,
0.004365535918623209,
0.008745158091187477,
-0.013913577422499657,
0.01375928707420826,
-0.03116205893456936,
-0.04808172956109047,
-0.026829440146684647,
-0.01633734628558159,
-0.0049008154310286045,
-0.03249933570623398,
-0.034554366022348404,
-0.018077850341796875,
0.019788164645433426,
-0.05560050159692764,
-0.0036018802784383297,
-0.01410397794097662,
-0.026377422735095024,
0.015419390052556992,
-0.003979903180152178,
-0.03547365590929985,
-0.008499300107359886,
-0.011709127575159073,
0.03418489918112755,
-0.012008135206997395,
-0.0012517031282186508,
0.009943068027496338,
0.007977805100381374,
0.015594983473420143,
-0.032125841826200485,
-0.024637017399072647,
0.018377775326371193,
0.002748754806816578,
0.005244998726993799,
0.002876218408346176,
-0.00237074913457036,
-0.01105633843690157,
-0.01640148088335991,
0.0030569161754101515,
-0.017459966242313385,
0.02175619825720787,
0.013708354905247688,
-0.01243117731064558,
0.007049888838082552,
-0.0018750119488686323,
-0.004549860022962093,
-0.006904282607138157,
0.00042492011561989784,
0.05004199594259262,
-0.016024133190512657,
0.010188491083681583,
-0.016196666285395622,
-0.026947233825922012,
-0.00859764963388443,
-0.022292036563158035,
0.016870679333806038,
-0.01909465715289116,
-0.017236126586794853,
0.013670205138623714,
0.02546142414212227,
-0.007755458354949951,
-0.023928947746753693,
-0.02388136088848114,
0.010952134616672993,
-0.028520191088318825,
0.016910867765545845,
-0.0015240749344229698,
0.01019909605383873,
0.002799172652885318,
0.008237412199378014,
0.01528066024184227,
0.03505772352218628,
-0.022801313549280167,
0.031442299485206604,
0.016413934528827667,
0.012590417638421059,
-0.07488207519054413,
-0.004985054023563862,
0.030727889388799667,
-0.01700843870639801,
-0.06358646601438522,
0.028809037059545517,
-0.03515685349702835,
-0.02625613659620285,
-0.01727733016014099,
0.007142681162804365,
-0.02019437961280346,
0.02105051279067993,
-0.022989612072706223,
-0.019089343026280403,
0.013785749673843384,
-0.012139912694692612,
-0.01126812119036913,
-0.002987379441037774,
-0.007922051474452019,
-0.007153545506298542,
0.006927264854311943,
0.030005289241671562,
0.015221824869513512,
-0.0003435695543885231,
0.0008052740013226867,
-0.08119935542345047,
-0.011140234768390656,
0.0016068053664639592,
-0.017127882689237595,
0.014918672852218151,
-0.0613369420170784,
0.008347240276634693,
-0.01083669438958168,
0.030278563499450684,
-0.01817994937300682,
-0.018400870263576508,
-0.007985950447618961,
-0.0021028700284659863,
0.006106752436608076,
0.016997816041111946,
-0.006497998721897602,
0.015956683084368706,
0.021866517141461372,
-0.02915852703154087,
0.009633314795792103,
0.0005863751284778118,
0.00008930964395403862,
-0.009461335837841034,
0.015538685023784637,
-0.00886008981615305,
-0.0170613843947649,
-0.007396267727017403,
0.013746640644967556,
-0.0033478308469057083,
-0.01789560727775097,
-0.010443577542901039,
0.0017482987605035305,
0.0004129956942051649,
0.002336167497560382,
-0.002906106412410736,
-0.012619579210877419,
-0.013270492665469646,
-0.028008978813886642,
-0.021661190316081047,
-0.006800830829888582,
0.003079934511333704,
0.006784358061850071,
0.02500973828136921,
0.015340819954872131,
-0.012198563665151596,
-0.03533381223678589,
0.004756002686917782,
-0.0190694909542799,
0.015000615268945694,
-0.03371374309062958,
0.005643269047141075,
0.017194839194417,
0.005555604584515095,
0.0026367749087512493,
-0.013785933144390583,
-0.0008908654563128948,
-0.012359252199530602,
-0.0009389691986143589,
-0.004635228309780359,
-0.009855782613158226,
-0.009405412711203098,
0.008906940929591656,
0.023353496566414833,
0.07104454934597015,
-0.0005228724330663681,
-0.0013281869469210505,
-0.0031989095732569695,
0.0026433109305799007,
0.0020134830847382545,
-0.011463172733783722,
-0.02790149115025997,
-0.010697674937546253,
-0.01651374064385891,
0.018837880343198776,
0.004423367325216532,
-0.03383468836545944,
0.010811857879161835,
0.01148657314479351,
-0.02973637357354164,
0.03789864480495453,
0.03241317719221115,
-0.04728975519537926,
0.026425397023558617,
0.02545872889459133,
0.023829711601138115,
-0.006753031630069017,
0.013341502286493778,
0.01639196090400219,
-0.0015138342278078198,
-0.01991117373108864,
-0.000021608546376228333,
0.006335006095468998,
-0.00989870261400938,
0.0010569081641733646,
-0.012748144567012787,
0.011670911684632301,
0.03587304428219795,
0.019042573869228363,
-0.0171172134578228,
0.007467620074748993,
0.008254768326878548,
-0.011365160346031189,
0.018289396539330482,
-0.0075559793040156364,
-0.012236680835485458,
-0.007149467244744301,
0.0003650893922895193,
0.005825425498187542,
0.0009145960211753845,
-0.000856948085129261,
-0.005409540608525276,
-0.013175658881664276,
0.009892613627016544,
0.020229198038578033,
0.006046185735613108,
0.036387838423252106,
-0.0005820407532155514,
0.00024803029373288155,
-0.00016788532957434654,
-0.006904758512973785,
0.015979081392288208,
0.01987292617559433,
-0.006970279384404421,
0.003531054826453328,
-0.01430823840200901,
0.024552706629037857,
-0.02278950996696949,
-0.004412510432302952,
-0.02222602441906929,
-0.005399724468588829,
-0.004904864355921745,
-0.04661700502038002,
0.018854066729545593,
0.02152886614203453,
0.00009522493928670883,
0.011644862592220306,
-0.0049688080325722694,
0.009798410348594189,
0.00591147318482399,
-0.003397993743419647,
-0.004293191246688366,
0.016994444653391838,
0.0036952693480998278,
-0.013114582747220993,
0.04178520292043686,
-0.02811407670378685,
0.013114433735609055,
-0.005751388147473335,
-0.011816499754786491,
-0.020154429599642754,
0.008676139637827873,
-0.006988295819610357,
0.006816273555159569,
0.006313652731478214,
0.005418865475803614,
0.0028774505481123924,
0.0031017581932246685,
0.006392802577465773,
0.034981533885002136,
0.019602764397859573,
-0.0030223981011658907,
0.01714782603085041,
-0.004562340676784515,
-0.0008855399210005999,
-0.003601811593398452,
-0.0018469186034053564,
-0.0011957695242017508,
0.023759014904499054,
-0.005951515398919582,
-0.008590565994381905,
-0.025092869997024536,
0.01333936769515276,
0.02468770369887352,
-0.016444221138954163,
0.001772766700014472,
0.03429011255502701,
-0.00936335138976574,
-0.0005817348137497902,
0.027806004509329796,
-0.029172008857131004,
-0.024428145959973335,
-0.01966668665409088,
-0.013148888945579529,
0.006925058551132679,
-0.008460012264549732,
0.018153367564082146,
-0.008141865953803062,
0.0038409808184951544,
-0.00713454419746995,
-0.008611243218183517,
0.024718087166547775,
0.02954661101102829,
0.02550935000181198,
0.013388779014348984,
0.01599399745464325,
-0.03662484139204025,
0.008302144706249237,
0.032211802899837494,
-0.013743732124567032,
-0.007147800177335739,
0.015572944656014442,
-0.01616331934928894,
0.0025345231406390667,
-0.005759485065937042,
0.010619714856147766,
0.006600138731300831,
0.0029945375863462687,
0.0061954958364367485,
-0.008885588496923447,
0.004628658294677734,
-0.015527109615504742,
0.011183149181306362,
-0.0006656453479081392,
-0.0021988502703607082,
0.0014978949911892414,
0.02134963497519493,
-0.004827246535569429,
0.020768700167536736,
0.029905308037996292,
0.017834527418017387,
0.0013381079770624638,
-0.016054844483733177,
-0.013582682237029076,
-0.0022848863154649734,
0.009518323466181755,
0.02311822958290577,
-0.0004329034127295017,
0.02705046907067299,
0.01094578206539154,
0.004888185299932957,
-0.005332619417458773,
-0.04252113774418831,
0.0361628532409668,
0.031423747539520264,
-0.016550246626138687,
-0.017622599378228188,
0.011297334916889668,
0.01547915767878294,
-0.00540576409548521,
0.00012384401634335518,
0.0068781012669205666,
0.013365328311920166,
0.013758844695985317,
0.03350541740655899,
-0.01722947135567665,
0.0010249712504446507,
-0.011692910455167294,
0.020441845059394836,
-0.0313224159181118,
-0.004654050804674625,
0.002294514561071992,
-0.005368035286664963,
0.012791486456990242,
-0.029869668185710907,
0.03371720761060715,
0.00460368487983942,
-0.003947881981730461,
-0.01988498866558075,
0.014114520512521267,
0.026249505579471588,
-0.0028099631890654564,
-0.010534072294831276,
0.01688235066831112,
-0.012040272355079651,
-0.040998946875333786
] | [
0.04424705728888512,
-0.028206396847963333,
0.22938421368598938,
0.13209493458271027,
-0.1391899287700653,
0.4687286615371704,
0.1252373605966568,
-0.836912989616394,
0.011984601616859436,
-0.45837926864624023,
-0.058422159403562546,
0.4005391001701355,
0.4213482737541199,
0.07076022773981094,
0.041263680905103683,
0.8351811170578003,
0.2813231348991394,
0.07908327132463455,
0.12589548528194427,
-0.6866649389266968,
-0.10292258858680725,
-0.16603794693946838,
0.6934293508529663,
0.14107313752174377,
-0.11183395981788635,
0.04305575415492058,
0.045951228588819504,
-0.3065520226955414,
0.10731137543916702,
0.005301518365740776,
-0.06239311024546623,
0.752755343914032,
-0.08698635548353195,
-0.29347139596939087,
-0.1216183602809906,
0.0541616715490818,
0.3956987261772156,
-0.1679658740758896,
0.1460370123386383,
-0.6924277544021606,
-0.29387250542640686,
-0.20167121291160583,
0.2009895294904709,
0.665226936340332,
-0.07082461565732956,
-0.19109128415584564,
-1.4274067878723145,
-0.08485352993011475,
0.06610625982284546,
0.2795748710632324,
0.02695678360760212,
0.5712461471557617,
0.5328707098960876,
-0.18986628949642181,
-0.14768709242343903,
0.36216434836387634,
-0.23834112286567688,
-0.4197940230369568,
0.36783626675605774,
-0.6844102740287781,
0.40165337920188904,
0.09347447752952576,
0.02151600457727909,
0.37631869316101074,
-0.3743792474269867,
-0.20508649945259094,
0.28376761078834534,
0.12626643478870392,
-0.07146885991096497,
0.04792581498622894,
0.23375841975212097,
0.20465898513793945,
-0.36647477746009827,
-0.007645355071872473,
0.08772900700569153,
-0.20843203365802765,
-0.06456606090068817,
-0.008991524577140808,
0.3697967827320099,
-0.14882901310920715,
0.10377761721611023,
-0.22412240505218506,
0.1551496684551239,
-0.1846553236246109,
0.3074776530265808,
0.3063912093639374,
0.30582302808761597,
0.08771799504756927,
-0.5731615424156189,
0.3296207785606384,
-0.45301392674446106,
-0.3721616864204407,
0.3272192180156708,
0.4929436445236206,
-0.0763779953122139,
0.11704779416322708,
0.30583757162094116,
-0.3951241075992584,
0.18820427358150482,
0.061393652111291885,
0.002073995303362608,
-0.2747136354446411,
-0.38907933235168457,
-0.07510240375995636,
-0.6079983115196228,
0.010877948254346848,
-0.16956555843353271,
-0.5639933943748474,
-0.47208064794540405,
-0.2042531818151474,
-0.9669109582901001,
-0.24187056720256805,
-0.39401161670684814,
-0.20560014247894287,
-0.17113205790519714,
0.13051308691501617,
-0.04915263503789902,
-0.18038232624530792,
-0.43871843814849854,
0.43634557723999023,
-0.44618865847587585,
1.032082438468933,
-0.31470465660095215,
0.4137107729911804,
-0.002902566222473979,
0.06152407452464104,
0.6617790460586548,
0.22818922996520996,
-0.11734127998352051,
0.14831285178661346,
-0.06851974874734879,
0.49128445982933044,
-0.2796238362789154,
-0.15122008323669434,
-0.2291181981563568,
-0.16104957461357117,
0.020308533683419228,
0.7352015972137451,
-0.5203213095664978,
0.22962205111980438,
-0.0006665066466666758,
-0.6819407939910889,
-0.18473948538303375,
-0.12004941701889038,
0.5035414695739746,
-0.5003546476364136,
-0.24209275841712952,
0.22750361263751984,
-0.13638553023338318,
-0.006210847292095423,
0.10726999491453171,
0.09572973102331161,
-0.2797018587589264,
0.39070653915405273,
-0.2814755141735077,
0.8944486975669861,
-0.6143476366996765,
-0.5305858254432678,
-0.07566607743501663,
0.06596431881189346,
0.2137506604194641,
0.20862174034118652,
-0.4118157625198364,
-0.049120113253593445,
0.45867305994033813,
0.12458649277687073,
0.7775629758834839,
-0.23690137267112732,
0.0035645326133817434,
0.3816775977611542,
-0.47995811700820923,
-0.32980430126190186,
-0.22782783210277557,
-0.8021088242530823,
-0.3464649021625519,
0.10999436676502228,
0.32929325103759766,
0.3004177510738373,
-0.14056824147701263,
0.46468842029571533,
-0.5407121181488037,
-0.08637384325265884,
-0.07658734172582626,
-0.6382051706314087,
-0.11772765219211578,
-0.05116352066397667,
0.583046555519104,
-0.01717621460556984,
0.2571408152580261,
0.2975224256515503,
0.1672361046075821,
-0.520293116569519,
0.8966013789176941,
-0.5489006042480469,
1.820358157157898,
-0.21455398201942444,
0.2644578814506531,
0.986348032951355,
-0.05700794234871864,
-0.1947626918554306,
0.20583702623844147,
0.033451005816459656,
0.8522118330001831,
-0.23353104293346405,
-0.49870240688323975,
0.13118691742420197,
0.052033182233572006,
-0.14940696954727173,
-0.5561835765838623,
-0.20237046480178833,
0.16884705424308777,
0.046111494302749634,
-0.1823725551366806,
-0.23579172790050507,
0.30231231451034546,
-0.24036277830600739,
0.3682742118835449,
0.212461918592453,
0.1118798553943634,
-0.19715997576713562,
0.38353896141052246,
0.017542798072099686,
0.6823346018791199,
0.6723500490188599,
0.12697988748550415,
0.07791662216186523,
0.49806496500968933,
0.29944345355033875,
0.3652215003967285,
-0.35916614532470703,
-0.26349812746047974,
-0.3510427176952362,
-0.10721631348133087,
-0.013463425450026989,
0.1419854760169983,
-0.21446222066879272,
-0.28710320591926575,
0.1058131605386734,
0.00401926226913929,
-0.37159794569015503,
-0.19051988422870636,
0.7236624360084534,
-0.2869992256164551,
0.29414647817611694,
0.30900582671165466,
-0.5935903787612915,
0.10170144587755203,
0.3690294027328491,
-0.9954726099967957,
-0.1140761524438858,
-0.09677353501319885,
0.3098461925983429,
0.47662174701690674,
-0.2554548680782318,
0.09796997904777527,
-0.05272659659385681,
0.12151439487934113,
-0.7219603657722473,
-0.2569511830806732,
-0.416839063167572,
0.24124674499034882,
0.04128333553671837,
0.12919896841049194,
0.1693650335073471,
0.36414283514022827,
-0.30993354320526123,
-0.8687567710876465,
-0.8224272131919861,
0.7884917259216309,
0.08495008945465088,
0.5986008644104004,
0.020162038505077362,
-0.23780839145183563,
-0.26751676201820374,
-0.13284583389759064,
-0.5307878255844116,
0.31075215339660645,
0.4743275046348572,
-0.5479333400726318,
-0.1404448300600052,
0.020840326324105263,
0.5164433717727661,
0.7433546781539917,
-0.42601728439331055,
0.41738322377204895,
0.21828414499759674,
-0.12500621378421783,
-0.11350271850824356,
-0.3599868416786194,
-0.3310549557209015,
0.046501368284225464,
0.10992033034563065,
-0.18855158984661102,
-0.3164399564266205,
0.46893131732940674,
0.3064270615577698,
-0.430349200963974,
0.8198358416557312,
0.557072639465332,
-0.007257574237883091,
-0.24424253404140472,
0.3766949474811554,
0.18024727702140808,
-0.481181800365448,
-0.2546370029449463,
-0.5758463144302368,
-0.6206616759300232,
0.17819362878799438,
-6.036352634429932,
0.02475443296134472,
-0.48878222703933716,
-0.308212548494339,
0.17196045815944672,
-0.08089794218540192,
0.385876327753067,
-0.15245682001113892,
0.12746645510196686,
-0.20429524779319763,
0.31896311044692993,
0.45733171701431274,
-0.18006369471549988,
0.08248066902160645,
-0.05741821229457855,
0.5249548554420471,
0.526794970035553,
-0.32763540744781494,
0.7381889224052429,
0.1381073147058487,
0.01901107467710972,
-0.4909456968307495,
-0.25136029720306396,
0.38445279002189636,
0.18316911160945892,
-0.27447056770324707,
-1.0819973945617676,
0.3464316725730896,
-0.5860995650291443,
-0.10426046699285507,
0.06446152925491333,
-0.292375773191452,
-0.3940106928348541,
-0.16863705217838287,
0.4281309247016907,
0.13613802194595337,
-0.09403403848409653,
0.3597252666950226,
0.08076812326908112,
-0.381063312292099,
-0.024860583245754242,
0.13226784765720367,
-0.36076459288597107,
-0.3528814911842346,
0.5218760967254639,
0.15655769407749176,
0.12586720287799835,
0.2603488564491272,
-0.11462002247571945,
0.4250388741493225,
0.1271054893732071,
-0.3549428880214691,
0.4610919654369354,
0.7271350026130676,
0.4542810916900635,
-0.28882965445518494,
-0.1969144195318222,
0.028307117521762848,
-0.29682108759880066,
0.4099773168563843,
-0.5160877108573914,
-0.49568504095077515,
-0.06270027905702591,
-0.9608993530273438,
-0.11639969050884247,
0.16846813261508942,
-0.49699488282203674,
-0.2553471028804779,
-0.08038049191236496,
-0.3261546790599823,
-0.07657872885465622,
0.3840056359767914,
0.04517386108636856,
-0.5530646443367004,
0.1391356736421585,
-0.7759807705879211,
0.5475313067436218,
0.457771897315979,
-0.2921953499317169,
0.10247302055358887,
-0.3791947662830353,
-0.09823644161224365,
-0.1768709123134613,
-0.08996117115020752,
0.35571539402008057,
-0.09881588071584702,
0.19937331974506378,
-0.9039244055747986,
0.21913275122642517,
0.5147318243980408,
0.05929792299866676,
-0.19973132014274597,
0.1818496733903885,
0.3310665488243103,
-0.23176832497119904,
0.018438948318362236,
0.3479696810245514,
0.30820003151893616,
0.09382065385580063,
-0.1539701670408249,
0.43762272596359253,
-0.058334365487098694,
-0.1410951018333435,
-0.44955652952194214,
-0.3588939309120178,
0.44005104899406433,
-0.1742144674062729,
0.019966477528214455,
0.7053921222686768,
-0.6869887709617615,
0.3414115309715271,
-0.48706987500190735,
-0.3819221556186676,
0.07549245655536652,
0.46087244153022766,
0.002319314517080784,
-0.11163955181837082,
-0.02512267790734768,
0.8879187107086182,
-0.053401440382003784,
0.5287743210792542,
-0.051924001425504684,
-0.3842857778072357,
-0.03542102128267288,
-0.007507063448429108,
-0.10708676278591156,
-0.202271968126297,
0.5294614434242249,
-0.9229429960250854,
0.2880382537841797,
0.5075911283493042,
0.5642640590667725,
-0.3557831645011902,
0.3919617533683777,
0.2245086282491684,
-0.6251378059387207,
-0.21951143443584442,
0.21940097212791443,
-0.02085196226835251,
-0.06293879449367523,
-0.07319654524326324,
-0.015178089961409569,
-0.1614762544631958,
0.027862926945090294,
0.6295003294944763,
-0.1520530730485916,
-0.3267419934272766,
0.1876855492591858,
-0.620481550693512,
0.30991601943969727,
0.6616466641426086,
-0.08883752673864365,
0.08621169626712799,
-0.03185462951660156,
-0.1699819564819336,
0.3509082496166229,
0.4500202536582947,
-0.09974414110183716,
0.2674371302127838,
-0.2455332726240158,
0.5754901766777039,
0.08947150409221649,
-0.9550649523735046,
-0.23344403505325317,
0.06657303869724274,
-0.6307951211929321,
-0.6484200954437256,
-0.10413065552711487,
0.042556293308734894,
0.08026772737503052,
-0.06921830028295517,
-0.3821691572666168,
-0.44198718667030334,
-0.10304069519042969,
0.33522820472717285,
-0.2534818649291992,
-0.5116048455238342,
-0.032616566866636276,
0.28690865635871887,
-0.06882680952548981,
0.3101814389228821,
-0.14249011874198914,
-0.0359264612197876,
0.2521374225616455,
0.6286203265190125,
0.27095070481300354,
-0.42977651953697205,
-0.07983633130788803,
0.08256154507398605,
0.06762588769197464,
0.46236279606819153,
0.00155333720613271,
0.3304920196533203,
0.26262518763542175,
0.1891738623380661,
0.1365218311548233,
0.5953351855278015,
0.7957959175109863,
-0.0946059376001358,
-0.338928759098053,
-0.17606067657470703,
0.31589192152023315,
0.048366252332925797,
0.5627201199531555,
0.8676631450653076,
-0.0023094681091606617,
-0.03795875236392021,
0.25510627031326294,
-0.4664784073829651,
-0.15647685527801514,
-0.12695345282554626,
-0.9918610453605652,
-0.20613063871860504,
0.13089138269424438,
-0.19221442937850952,
-0.08568547666072845,
0.1309485286474228,
-0.48443788290023804,
-0.3976437449455261,
0.19721834361553192,
0.4269634783267975,
-0.3089550733566284,
-0.6431763172149658,
-0.16271544992923737,
-0.15048685669898987,
-0.3872365653514862,
0.2966998517513275,
-0.6774681806564331,
0.2002420723438263,
-0.13374651968479156,
-0.6364599466323853,
-0.3865624666213989,
0.5913686752319336,
0.16630788147449493,
0.08768434077501297,
0.23963794112205505,
-0.7018742561340332,
-0.06704821437597275,
-0.46174222230911255,
-0.1263069212436676,
-0.2778257131576538,
0.963676393032074,
0.090065598487854,
-0.15328338742256165,
0.22772248089313507,
0.253435343503952,
0.17380288243293762,
-0.3693079352378845,
-0.14513275027275085,
-0.2083461433649063,
0.22023148834705353,
-0.007192450575530529,
-0.2120899111032486,
-0.03597085177898407,
0.6647217869758606,
0.40481436252593994,
-0.1454821676015854,
-0.48467016220092773,
-0.13704903423786163,
0.21912820637226105,
0.19253931939601898,
-0.23314368724822998,
-0.006292855832725763,
0.0967414602637291,
-0.16281038522720337,
0.009996711276471615,
-0.14544668793678284,
-0.8924497961997986,
0.06971137970685959,
-0.18889470398426056,
0.3106522560119629,
0.003808779176324606,
0.024465491995215416,
0.1514924317598343,
-0.25766223669052124,
0.1969737559556961,
-0.1720137745141983,
0.24524956941604614,
-0.03165445476770401,
0.191275492310524,
-0.07610014826059341,
-0.49032095074653625,
0.11730461567640305,
-0.16843383014202118,
0.711203932762146,
-0.24307754635810852,
0.010518580675125122,
0.015252365730702877,
0.041423700749874115,
-0.13899704813957214,
-0.2891461253166199,
0.3050104081630707,
-1.0146201848983765,
-0.37586453557014465,
0.14321549236774445,
0.5488088726997375,
0.15818995237350464,
0.14207489788532257,
-0.04563060402870178,
0.012701915577054024,
-0.6088950037956238,
0.8953626751899719,
0.3905618190765381,
-0.12720005214214325,
-0.049817174673080444,
0.11012909561395645,
0.09950301051139832,
-0.1922389268875122,
-0.09481731802225113,
0.004637208301573992,
0.724816620349884,
0.11094105988740921,
0.2924743592739105,
0.1788727194070816,
-0.2785400450229645,
-0.3351971209049225,
-0.1949339658021927,
0.09866763651371002,
0.4034261107444763,
0.403389573097229,
-0.17119768261909485,
0.4738064706325531,
0.9587796926498413,
-0.27639642357826233,
-0.2445593625307083,
0.5822945833206177,
-0.2050027698278427,
0.024902760982513428,
-0.2515104413032532,
0.9259468913078308,
0.44365090131759644,
0.5333115458488464,
-0.04644910246133804,
0.47856274247169495,
0.4072082042694092,
0.02091927081346512,
0.07282909750938416,
-0.06328225880861282,
0.16244736313819885,
-0.07281306385993958,
0.8888389468193054,
0.15318840742111206,
0.2951652705669403,
0.15676911175251007,
0.10519365221261978,
0.3229961097240448,
0.0401233434677124,
0.3616101145744324,
-0.2886340618133545,
0.2511017620563507,
0.35470497608184814,
-0.31533512473106384,
-0.28342166543006897,
0.02704755961894989,
-0.2263619750738144,
0.3483124077320099,
0.23622828722000122,
0.0034259213134646416,
-0.5399492979049683,
0.36944103240966797,
-0.050650306046009064,
0.2460266649723053,
0.18673399090766907,
0.005030010361224413,
-0.18219256401062012,
-0.09890877455472946,
0.07580987364053726,
0.4713480770587921,
0.06918292492628098,
-0.2005748599767685,
-0.14088819921016693,
0.4509640336036682,
-0.28715911507606506,
0.002690499182790518,
-0.004403476603329182,
-0.6973554491996765,
-0.4628012180328369,
-0.09049327671527863,
0.17846699059009552,
0.7462682723999023,
-0.18695637583732605,
0.13696742057800293,
-0.44384104013442993,
-0.6554404497146606,
-0.23271191120147705,
-0.06487199664115906,
-0.10650623589754105,
0.29148373007774353,
0.23253744840621948,
-0.0548258014023304,
0.1237323209643364,
-0.9349926710128784,
-0.019366374239325523,
0.020330358296632767,
-0.11424943059682846,
0.05416480079293251,
-0.23980122804641724,
0.07826492935419083,
0.7275173664093018,
0.4206864535808563,
-0.10457921028137207,
0.11163665354251862,
-0.4321483075618744,
0.5179715156555176,
-0.300992876291275,
0.6434959173202515,
-0.506050705909729,
-0.33712443709373474,
-0.20101699233055115,
-0.07869134098291397,
0.6173630952835083,
0.5614262819290161,
-0.3802386224269867,
0.29376500844955444,
-0.23228950798511505,
0.0729295164346695,
0.8389697670936584,
-0.4264752268791199,
-0.22219933569431305,
-0.4235248267650604,
-0.7626376152038574,
-0.20805302262306213,
0.5824397206306458,
-0.29965630173683167,
-0.1521691381931305,
-0.08896967023611069,
0.08778856694698334,
0.27341267466545105,
0.067022405564785,
0.39996138215065,
-0.5159260630607605,
-0.3179451525211334,
-0.6817097067832947,
0.1525059938430786,
-0.584830641746521,
0.2746148705482483,
-0.05019252374768257,
0.12602689862251282,
-0.12486421316862106,
-0.2321101576089859,
-0.19450929760932922,
-0.48942747712135315,
0.03995293006300926,
0.2703215777873993,
0.10809594392776489,
0.3392319083213806,
0.004432056099176407,
-0.6606082320213318,
-0.5699204206466675,
0.5342682600021362,
0.1284312605857849,
-0.1221071109175682,
0.13087406754493713,
-0.6523812413215637,
-0.19234776496887207,
-0.11857185512781143,
-0.19247929751873016,
-0.3464207053184509,
-0.20927710831165314,
-0.38808172941207886
] |
To investigate the impact of the 2017 revisions of McDonald criteria on the diagnosis of multiple sclerosis (MS) in a cohort of patients with clinically isolated syndrome (CIS) and dissemination in space (DIS) of demyelinating lesions. We retrospectively analyzed 137 patients with CIS + DIS from two Italian MS centers. Application of the 2017 revisions of McDonald criteria in our cohort led to a diagnosis of MS in 82.5% of the patients who could have not been diagnosed with MS according to the previous criteria at the time of the first demyelinating event. After a follow-up of 3.8 ± 2.9 years, 85.8% of these patients eventually satisfied also the previous (2010) criteria. Application of the 2017 revisions of McDonald criteria results in an earlier diagnosis of MS in a large percentage of CIS patients destined to convert to MS. | [
0.005691714584827423,
0.009459542110562325,
-0.018330171704292297,
0.013162518851459026,
0.018489239737391472,
-0.0022647089790552855,
0.009731857106089592,
-0.008619701489806175,
-0.008242546580731869,
-0.008886994794011116,
-0.009347917512059212,
-0.0021219109185039997,
-0.0019345328910276294,
0.01501409336924553,
0.0013945801183581352,
-0.024895526468753815,
-0.017424780875444412,
0.00933259166777134,
0.011304897256195545,
-0.006952471099793911,
0.027256369590759277,
-0.0005266908556222916,
0.010031698271632195,
0.04071616008877754,
0.0007333406247198582,
0.014161594212055206,
-0.0034276023507118225,
0.00008899951353669167,
0.0017929200548678637,
-0.003312915563583374,
-0.00808236189186573,
0.0042129806242883205,
-0.007544719614088535,
-0.005556588061153889,
0.0009480830049142241,
-0.012075692415237427,
0.0050653740763664246,
0.012986975722014904,
0.014545252546668053,
-0.006063941400498152,
0.0037464634515345097,
-0.012988759204745293,
0.006399637088179588,
0.00502631114795804,
-0.005284449551254511,
0.006673948839306831,
-0.0044240569695830345,
-0.01721825636923313,
-0.0011573496740311384,
0.011281265877187252,
-0.012177197262644768,
-0.025774981826543808,
-0.009154340252280235,
-0.012761075049638748,
-0.005701389163732529,
-0.003965471871197224,
0.018278971314430237,
0.009705569595098495,
-0.006688102148473263,
0.0030057919211685658,
-0.0143617894500494,
-0.01476023718714714,
0.013810547068715096,
-0.010879484936594963,
-0.011615583673119545,
-0.06727553904056549,
0.03542450815439224,
0.018081076443195343,
-0.004429203923791647,
-0.0015406487509608269,
-0.005616425070911646,
0.010985298082232475,
-0.014867173507809639,
0.01203148066997528,
-0.0003839049022644758,
-0.00597920548170805,
-0.00487514678388834,
0.007392229977995157,
0.021169520914554596,
-0.012165372259914875,
-0.00686808954924345,
0.006268486380577087,
-0.0259387344121933,
0.008759593591094017,
0.010958991013467312,
0.00012722192332148552,
-0.023708179593086243,
-0.019417382776737213,
-0.005935083143413067,
0.015072774142026901,
0.008448520675301552,
0.014104075729846954,
-0.005559645593166351,
-0.012612828984856606,
-0.02086169645190239,
-0.015516572631895542,
-0.0026708953082561493,
0.022748272866010666,
0.0046661728993058205,
-0.00644698366522789,
-0.016687452793121338,
0.012986916117370129,
0.02558361366391182,
0.018644412979483604,
-0.02560311183333397,
0.0056906817480921745,
-0.024350963532924652,
0.006856122054159641,
0.0005924822762608528,
0.0011702205520123243,
-0.002099224366247654,
0.020518742501735687,
-0.00228959321975708,
0.013730717822909355,
0.016614699736237526,
0.032192692160606384,
0.0020314669236540794,
0.003052364569157362,
0.0033475286327302456,
-0.021564282476902008,
0.009309643879532814,
0.020437508821487427,
-0.001205062959343195,
-0.011364467442035675,
-0.0026036961935460567,
0.013941270299255848,
0.0032436237670481205,
0.00028670718893408775,
-0.009144283831119537,
0.014974793419241905,
-0.007247756700962782,
-0.003166505368426442,
-0.00376699585467577,
0.0015525200869888067,
0.022415325045585632,
0.002963258419185877,
-0.02925264462828636,
-0.011232193559408188,
-0.0023047865834087133,
-0.0025019929744303226,
-0.019113894551992416,
0.012391671538352966,
-0.006348500959575176,
0.008708673529326916,
0.011564800515770912,
0.007578616496175528,
-0.02702219970524311,
0.014834308065474033,
0.011149195954203606,
0.012180104851722717,
0.01162128895521164,
0.002280737739056349,
-0.019004041329026222,
-0.014471679925918579,
0.005318261682987213,
-0.009324111975729465,
-0.007520836777985096,
-0.0011967122554779053,
-0.0012393816141411662,
0.00583948940038681,
0.006454342044889927,
0.014129150658845901,
0.01772843301296234,
0.007692132145166397,
0.012705766595900059,
-0.0002863863483071327,
-0.009332789108157158,
-0.000050293165259063244,
-0.007816185243427753,
0.004542100243270397,
0.0005635385168716311,
0.008420346304774284,
0.015153700485825539,
0.0065554166212677956,
0.00862623006105423,
-0.0036249717231839895,
0.006936937570571899,
0.008346779271960258,
-0.008547096513211727,
0.0674307569861412,
-0.0227713230997324,
0.004618526436388493,
-0.008073631674051285,
0.01271140482276678,
0.02920999377965927,
-0.004393869079649448,
0.011805728077888489,
-0.005708254873752594,
-0.037692565470933914,
0.0011059409007430077,
-0.00412621907889843,
0.03377220034599304,
-0.002718293806537986,
-0.01226064469665289,
-0.018678931519389153,
0.002568915020674467,
0.004998064134269953,
0.0006503314943984151,
0.032346419990062714,
0.004391584545373917,
0.03604225069284439,
-0.010054226033389568,
0.032163746654987335,
-0.00031111319549381733,
0.031972963362932205,
0.016962610185146332,
0.022198868915438652,
0.01892295479774475,
-0.017147677019238472,
0.0019797724671661854,
0.006010224111378193,
-0.00320224417373538,
0.008676290512084961,
-0.017262831330299377,
-0.01758498325943947,
-0.00619659386575222,
0.01210652943700552,
-0.0004364154301583767,
-0.0036847745068371296,
-0.011678365990519524,
-0.00507524237036705,
-0.010204127058386803,
0.009143345057964325,
-0.004417287185788155,
-0.006956849712878466,
-0.022458046674728394,
0.006081790663301945,
0.006234854459762573,
0.005712119396775961,
-0.01897728256881237,
-0.016295453533530235,
0.0085048982873559,
-0.011868452653288841,
0.0015604328364133835,
0.002619334962219,
0.01867402344942093,
0.011583739891648293,
0.018340539187192917,
0.017122412100434303,
-0.019199518486857414,
-0.00985669158399105,
-0.04241274297237396,
0.03437561169266701,
0.010514061897993088,
0.038579061627388,
-0.012142677791416645,
-0.012054918333888054,
0.009561574086546898,
0.02065226435661316,
0.0010850634425878525,
0.005963604431599379,
-0.005571835674345493,
-0.005519485101103783,
0.016108740121126175,
-0.012135679833590984,
-0.007417845539748669,
-0.010806147009134293,
-0.000261752400547266,
0.023162417113780975,
-0.015904482454061508,
0.014175284653902054,
0.008104515261948109,
-0.020861411467194557,
0.03641129657626152,
-0.01806948147714138,
0.017578482627868652,
-0.001510482281446457,
0.012216426432132721,
0.011028544045984745,
-0.017642278224229813,
0.00743122398853302,
-0.0018594748107716441,
-0.006552283186465502,
-0.08106832206249237,
-0.008625523187220097,
0.02878674492239952,
0.010707004927098751,
0.006901502143591642,
-0.016231708228588104,
-0.010020418092608452,
-0.005007429514080286,
-0.016315756365656853,
-0.01676938310265541,
0.013179185800254345,
0.018599510192871094,
-0.009208044037222862,
0.005632811225950718,
-0.025388292968273163,
0.004679078236222267,
0.0013356488198041916,
-0.0010115229524672031,
-0.0007470985874533653,
0.015316320583224297,
-0.006133622489869595,
-0.015968147665262222,
-0.0036007328890264034,
0.022587820887565613,
-0.006757544353604317,
-0.004261068068444729,
0.012449504807591438,
0.0015232854057103395,
0.0032021773513406515,
-0.004164563491940498,
-0.024053599685430527,
-0.01795979216694832,
0.02633458562195301,
-0.0160167645663023,
-0.022211380302906036,
0.0006647550035268068,
0.009779761545360088,
-0.009675760753452778,
-0.0008598072454333305,
0.005024967715144157,
0.0020800756756216288,
0.0018276635091751814,
0.016117531806230545,
-0.009162015281617641,
-0.0027673779986798763,
0.013513641431927681,
0.018420370295643806,
-0.0005917488597333431,
0.01775166019797325,
-0.02743508294224739,
0.01744772680103779,
-0.0012207168620079756,
-0.005445824936032295,
0.010602151975035667,
-0.015576155856251717,
-0.016281887888908386,
-0.010072080418467522,
-0.00745476083829999,
-0.005315556190907955,
-0.012647727504372597,
0.010707925073802471,
-0.027522103860974312,
0.018743516877293587,
0.002733158878982067,
-0.01330726407468319,
-0.016616515815258026,
0.0014553195796906948,
-0.022007646039128304,
-0.01823544129729271,
-0.002568405121564865,
-0.0068994672037661076,
-0.016244390979409218,
-0.008048291318118572,
-0.0036450140178203583,
-0.0008827904239296913,
-0.011702274903655052,
-0.014072146266698837,
0.009990090504288673,
-0.0015665183309465647,
0.0004321318119764328,
-0.0035084066912531853,
0.005183029919862747,
-0.009076226502656937,
-0.0033766799606382847,
-0.0025445104110985994,
0.0012340839020907879,
0.013547061011195183,
0.013739844784140587,
0.025492049753665924,
-0.006995318923145533,
-0.017219237983226776,
-0.014469610527157784,
-0.004171708598732948,
0.014155360870063305,
0.008094452321529388,
0.013919081538915634,
0.014689205214381218,
-0.019724737852811813,
-0.006095762364566326,
0.00860556773841381,
0.001539429184049368,
-0.0008492607157677412,
-0.018216704949736595,
-0.01092449389398098,
-0.007121383678168058,
0.0070805782452225685,
-0.010745720937848091,
-0.012795504182577133,
0.007084427401423454,
-0.0027791853062808514,
0.006843928713351488,
-0.012830972671508789,
-0.004473510198295116,
0.023402998223900795,
0.016713563352823257,
0.030279507860541344,
0.007936298847198486,
-0.018284354358911514,
0.07236018776893616,
0.013261076994240284,
-0.0045571583323180676,
-0.011047692969441414,
0.03222453221678734,
-0.018559299409389496,
-0.006080307066440582,
0.00752401165664196,
-0.005695002153515816,
0.016600878909230232,
0.010469416156411171,
-0.004422985482960939,
-0.019040726125240326,
0.01742681674659252,
-0.011364025995135307,
0.0038169159088283777,
-0.008356058038771152,
0.016803042963147163,
-0.0016473117284476757,
0.021220605820417404,
0.034007929265499115,
-0.0008392374729737639,
-0.007945505902171135,
0.027399830520153046,
0.020783372223377228,
-0.011875700205564499,
-0.0021297179628163576,
-0.017417721450328827,
-0.00982593558728695,
0.008972646668553352,
0.009713971987366676,
0.022134773433208466,
-0.007486441172659397,
0.015142233110964298,
-0.006705215200781822,
0.0014616259140893817,
-0.012623652815818787,
-0.00015314947813749313,
0.012717017903923988,
-0.0023525203578174114,
0.0101703479886055,
-0.01279973704367876,
-0.019623208791017532,
0.004070770926773548,
-0.016632918268442154,
-0.008384864777326584,
0.007177428808063269,
-0.005356630310416222,
-0.005885930731892586,
-0.0108084287494421,
0.0026015257462859154,
0.007219764869660139,
0.014733130112290382,
0.0242238137871027,
0.005762272980064154,
0.0012174933217465878,
0.007891474291682243,
-0.0022090065758675337,
-0.0009965787176042795,
-0.02408253587782383,
-0.02020072750747204,
0.0014817123301327229,
-0.009147205390036106,
-0.0037376638501882553,
-0.016116224229335785,
-0.017056170850992203,
-0.006211539730429649,
0.008077435195446014,
-0.013798700645565987,
-0.008197159506380558,
-0.0020554710645228624,
0.0009522568434476852,
-0.012423709034919739,
-0.021787239238619804,
-0.03345424681901932,
0.024543892592191696,
-0.018065467476844788,
-0.004638427868485451,
0.016652235761284828,
-0.008095826953649521,
-0.02859903872013092,
-0.013496778905391693,
0.01014654990285635,
0.014538430608808994,
-0.008828793652355671,
0.0015163328498601913,
-0.01938764750957489,
-0.07421502470970154,
-0.0021841535344719887,
0.004806753247976303,
-0.011590797454118729,
0.003069859929382801,
0.016653593629598618,
-0.021778978407382965,
0.007587537635117769,
0.013594232499599457,
-0.015343887731432915,
0.009930942207574844,
-0.005691245198249817,
-0.021281078457832336,
-0.016262724995613098,
0.011866284534335136,
0.006323820445686579,
-0.010399332270026207,
-0.013248562812805176,
-0.03854925185441971,
0.0007424247451126575,
-0.007636457681655884,
0.020815888419747353,
-0.017537008970975876,
0.0027189329266548157,
-0.012391161173582077,
-0.08128207921981812,
0.022736329585313797,
-0.009760763496160507,
0.0005492987111210823,
0.007642008364200592,
-0.016271719709038734,
0.008884072303771973,
-0.0018297710921615362,
-0.0022607403807342052,
-0.013529459945857525,
-0.0018148887902498245,
0.006571379955857992,
0.002627260982990265,
-0.012137746438384056,
0.00044780364260077477,
-0.003486873582005501,
0.004238869529217482,
0.004575265105813742,
-0.013699453324079514,
-0.003067860146984458,
-0.005150183103978634,
-0.0018624849617481232,
-0.002617968712002039,
0.0004943292587995529,
-0.011369284242391586,
-0.016102982684969902,
-0.008113676682114601,
0.01547163538634777,
0.0006190831772983074,
0.026813331991434097,
-0.00734833674505353,
0.004364364314824343,
-0.018731292337179184,
0.002511441009119153,
0.012595972046256065,
-0.015575512312352657,
0.014268080703914165,
0.005168315954506397,
-0.016282077878713608,
-0.0077188205905258656,
-0.008088935166597366,
-0.0034340666607022285,
-0.014796728268265724,
-0.01756894774734974,
-0.014930534176528454,
0.014946825802326202,
0.0059541743248701096,
-0.012815892696380615,
0.0038037095218896866,
-0.007783571258187294,
0.005705003626644611,
0.00947949942201376,
0.0186265017837286,
0.00770143885165453,
0.003342478070408106,
0.030816562473773956,
-0.01761336252093315,
0.04189174249768257,
0.008310261182487011,
0.014274255372583866,
0.0017380836652591825,
0.002141735516488552,
0.01997547224164009,
0.07270396500825882,
-0.031733207404613495,
0.009827865287661552,
-0.0009932098910212517,
0.004080638289451599,
-0.003054392524063587,
-0.019559942185878754,
0.018588272854685783,
-0.018299207091331482,
-0.003992578946053982,
-0.0014548180624842644,
-0.020218748599290848,
0.040303442627191544,
0.011481762863695621,
0.002034274162724614,
-0.013597927987575531,
-0.006821390241384506,
0.014072504825890064,
-0.02004777267575264,
0.010072685778141022,
0.01863400638103485,
0.005241545848548412,
-0.02803046628832817,
0.0034050627145916224,
0.02349804900586605,
-0.011882237158715725,
0.010443429462611675,
0.009589272551238537,
-0.007274667266756296,
0.02233012020587921,
-0.01626797392964363,
0.014357998967170715,
0.005744318477809429,
-0.0029102321714162827,
0.008269666694104671,
-0.01700356975197792,
0.00619371235370636,
0.012676005251705647,
0.007882008329033852,
0.04699208587408066,
0.02341580204665661,
-0.005676228553056717,
0.011288394220173359,
-0.009313831105828285,
0.019938336685299873,
0.02790967747569084,
0.005226773675531149,
-0.015267690643668175,
-0.014783257618546486,
-0.0065249232575297356,
-0.011685481294989586,
0.002107657492160797,
0.016710223630070686,
-0.0017145369201898575,
0.009346853941679,
0.022474966943264008,
-0.016898062080144882,
0.015962760895490646,
0.004050524905323982,
0.0012868340127170086,
0.01230650581419468,
-0.0018863838631659746,
0.0006396966055035591,
-0.017612086609005928,
-0.0016511566936969757,
0.01715172454714775,
0.023497823625802994,
-0.008309545926749706,
0.0012632496654987335,
0.013804612681269646,
-0.009104100987315178,
0.0020019272342324257,
0.009222092106938362,
0.005661638453602791,
0.012166865170001984,
0.03004949353635311,
-0.02614881843328476,
-0.022891264408826828,
0.004992242902517319,
0.017005711793899536,
-0.01352955587208271,
0.009625565260648727,
0.0012920177541673183,
-0.022516753524541855,
-0.006501848343759775,
0.007303794380277395,
-0.0021431907080113888,
0.010459075681865215,
-0.002618814818561077,
0.005649138242006302,
0.01356001291424036,
0.035194262862205505,
-0.00126444932539016,
0.02261955849826336,
0.0071287332102656364,
0.03317316621541977,
-0.004051978699862957,
0.007227011956274509,
-0.007368053309619427,
0.005756756756454706,
0.025505226105451584,
0.017750926315784454,
0.026579003781080246,
0.0040459707379341125,
-0.028662586584687233,
0.006214617285877466,
0.005996669642627239,
0.014468671754002571,
-0.014212368056178093,
-0.011193020269274712,
-0.013892297632992268,
-0.02290256693959236,
-0.00620774831622839,
0.008941717445850372,
-0.00517637562006712,
-0.006385086104273796,
0.014325304888188839,
-0.0073440480045974255,
-0.012352580204606056,
-0.013065477833151817,
-0.010315141640603542,
-0.02225388027727604,
0.008125273510813713,
0.012139799073338509,
0.013229011557996273,
-0.025753673166036606,
-0.0043625901453197,
0.02411491982638836,
0.001069679856300354,
0.00019917357712984085,
0.018503475934267044,
0.04105041176080704,
-0.014769725501537323,
-0.0016216123476624489,
-0.0049994634464383125,
-0.03110381029546261,
0.0019613720942288637,
0.010852474719285965,
-0.0007026731036603451,
-0.021504368633031845,
0.01951947622001171,
-0.007593053393065929,
0.0050374530255794525,
-0.02898131124675274,
0.00939468014985323,
-0.00038443924859166145,
0.006130770780146122,
-0.0013517802581191063,
0.005190420895814896,
-0.00001606589648872614,
-0.0071830060333013535,
0.0039160652086138725,
-0.007723536342382431,
-0.0014832706656306982,
0.0019731754437088966,
0.010163874365389347,
0.011580901220440865,
-0.013490449637174606,
-0.017927328124642372,
0.00794263556599617,
-0.0023387852124869823,
0.01911567896604538,
0.008135674521327019,
-0.004580882843583822,
0.013490832410752773,
0.006056861020624638,
0.005673148203641176,
0.0382431298494339,
-0.014125026762485504,
0.0045867678709328175,
0.005187223665416241,
0.00405849190428853,
-0.003090572077780962,
0.03763677179813385,
-0.014085952192544937,
0.00808057002723217,
0.013354020193219185,
0.004904891364276409,
-0.008495988324284554,
0.029779275879263878,
0.01661384291946888,
-0.0013242638669908047,
-0.004074256867170334,
-0.014213811606168747,
-0.006604296620935202,
0.0006663016974925995,
-0.005404126364737749,
-0.011238224804401398,
0.0036326423287391663,
-0.017639685422182083,
-0.0005927947349846363,
0.006104301195591688,
-0.015774138271808624,
-0.00923584308475256,
0.018041878938674927,
0.02069186046719551,
0.014995965175330639,
-0.013107146136462688,
-0.007049671374261379,
-0.0002572261728346348,
-0.005636249668896198,
-0.014254897832870483
] | [
0.006736605893820524,
-0.1543901264667511,
0.40492111444473267,
-0.008213232271373272,
0.1436033844947815,
0.6376838684082031,
0.406277060508728,
-0.4401122033596039,
-0.4980332553386688,
-0.7317685484886169,
-0.22422656416893005,
-0.13237512111663818,
0.033963341265916824,
0.4994644522666931,
0.2170025259256363,
0.7443225383758545,
0.3646472692489624,
-0.00170193612575531,
-0.2136901319026947,
-0.28375065326690674,
-0.01157240942120552,
-0.5457846522331238,
0.6428200602531433,
0.05665756016969681,
-0.43558382987976074,
-0.027558334171772003,
0.835661768913269,
0.060024194419384,
0.1559087485074997,
0.13084636628627777,
0.14910778403282166,
0.6789855360984802,
-0.019521916285157204,
-0.5851516723632812,
-0.22479520738124847,
0.3387041389942169,
-0.03332194313406944,
-0.08989784121513367,
-0.18700827658176422,
-0.19869370758533478,
-0.14524859189987183,
-0.19869433343410492,
-0.19542481005191803,
0.3558374047279358,
-0.16047213971614838,
-0.10121151804924011,
-1.5420100688934326,
0.3524312376976013,
-0.43743327260017395,
0.07824679464101791,
0.0984085276722908,
-0.12571212649345398,
0.4463376998901367,
0.1380460113286972,
-0.436758816242218,
0.20610976219177246,
-0.8457098007202148,
-0.2499578595161438,
0.10459943115711212,
-0.388895183801651,
0.23575526475906372,
-0.055836740881204605,
0.2767781615257263,
0.08904604613780975,
-0.22706837952136993,
0.2660742700099945,
0.314024418592453,
0.17357580363750458,
-0.3653064966201782,
-0.1418260931968689,
0.6905977129936218,
-0.008993791416287422,
-0.22600649297237396,
0.4059969484806061,
-0.20590738952159882,
-0.048422884196043015,
-0.01609264872968197,
-0.2039058357477188,
0.24171818792819977,
0.07084538787603378,
-0.13819460570812225,
-0.42902761697769165,
0.32196366786956787,
-0.06832187622785568,
0.46842658519744873,
0.006413960829377174,
-0.1561025083065033,
0.5579658150672913,
-0.17462074756622314,
0.1875562071800232,
-0.28998300433158875,
-0.3292343020439148,
0.4677655100822449,
0.643527626991272,
0.8039307594299316,
0.6103636622428894,
-0.10491427779197693,
0.048134807497262955,
0.06972939521074295,
0.00896057952195406,
0.04951571300625801,
-0.035347647964954376,
-0.4112449884414673,
-0.3130207359790802,
-0.024469880387187004,
-0.7212187647819519,
-0.24741846323013306,
-1.0445852279663086,
-0.4108057916164398,
-0.12705890834331512,
-0.7231693863868713,
0.0962667390704155,
-0.1941688060760498,
-0.3102028965950012,
-0.4606984555721283,
0.02934941090643406,
0.362534761428833,
-0.2985813021659851,
0.09785391390323639,
0.21212263405323029,
0.13937276601791382,
0.8042291402816772,
-0.17630718648433685,
0.12553496658802032,
-0.08652326464653015,
0.16011208295822144,
0.6339689493179321,
0.44252699613571167,
-0.5575079917907715,
0.4611470401287079,
0.07573992013931274,
0.3508365750312805,
-0.2718007564544678,
0.00030871087801642716,
0.05388619378209114,
-0.5925725698471069,
0.11973176896572113,
-0.16580499708652496,
0.05114377290010452,
0.02592766471207142,
-0.17825095355510712,
-0.478781133890152,
-0.8420883417129517,
0.12975651025772095,
0.07244956493377686,
-0.2682648301124573,
0.17054349184036255,
0.3388254940509796,
-0.35146966576576233,
-0.3780537545681,
-0.4082375466823578,
-0.14824959635734558,
-0.6773008108139038,
-0.15139171481132507,
0.034652549773454666,
0.6225148439407349,
-0.4191749095916748,
-0.18243516981601715,
-0.037958644330501556,
0.27825114130973816,
0.7431824803352356,
-0.03228433057665825,
-0.2866193950176239,
-0.07711886614561081,
0.5052469372749329,
-0.24899247288703918,
-0.011016248725354671,
0.028567617759108543,
0.06338690221309662,
0.22353975474834442,
-0.0377144031226635,
-0.3593829274177551,
0.0014619661960750818,
-0.6792924404144287,
-0.11864735931158066,
-0.08288908749818802,
0.26088881492614746,
0.07281597703695297,
0.24496901035308838,
0.11524226516485214,
-0.5557020306587219,
-0.5432385206222534,
0.06363696604967117,
-0.24487754702568054,
0.6516515016555786,
0.5022728443145752,
0.6632488965988159,
0.2346220314502716,
0.06311650574207306,
0.35410672426223755,
-0.06536872684955597,
-0.5834763050079346,
0.5858898758888245,
-0.8149297833442688,
1.6157771348953247,
-0.05496465414762497,
0.0454159714281559,
1.4069491624832153,
0.16411533951759338,
0.3721277117729187,
-0.20253410935401917,
0.1125837191939354,
0.45266982913017273,
0.07347612828016281,
-0.16096928715705872,
0.07152990251779556,
-0.1406424343585968,
-0.17456300556659698,
-0.41742146015167236,
0.27283209562301636,
0.32121312618255615,
-1.2454590797424316,
-0.3374372720718384,
0.11251651495695114,
0.06191076338291168,
-0.00711785489693284,
0.09542035311460495,
-0.15402789413928986,
-0.22923116385936737,
0.17677512764930725,
0.9966355562210083,
-0.5890102982521057,
0.5226155519485474,
0.27343645691871643,
0.03579692915081978,
0.6405302882194519,
0.2755751311779022,
0.20714551210403442,
0.6518281698226929,
-0.27658167481422424,
0.11762191355228424,
-0.03568108752369881,
0.5431709289550781,
-0.3926154673099518,
-0.08412504941225052,
-0.07534919679164886,
0.29074254631996155,
-0.18354763090610504,
0.15239174664020538,
0.32354727387428284,
-0.01818319782614708,
0.3495694696903229,
-0.3616909384727478,
0.2608840763568878,
0.055681534111499786,
-0.27238595485687256,
-0.14185066521167755,
0.18329517543315887,
-0.237270787358284,
-0.14374899864196777,
0.31177738308906555,
0.23673339188098907,
0.06797721982002258,
-0.37095317244529724,
-0.05603522062301636,
0.4001070261001587,
0.37552890181541443,
-0.8192893862724304,
-0.08797340840101242,
-0.6148609519004822,
0.04445398226380348,
0.15176072716712952,
0.24277719855308533,
-0.19792170822620392,
0.11579184234142303,
-0.8822783827781677,
-0.9961642622947693,
-0.20251815021038055,
0.8749657869338989,
0.5208367705345154,
0.801815927028656,
-0.39085549116134644,
-0.48400840163230896,
-0.011488834396004677,
-0.1374015063047409,
-0.575314462184906,
-0.1728113740682602,
0.6029084324836731,
-1.0024861097335815,
-0.753323495388031,
-0.02496420405805111,
0.5090653300285339,
0.7655359506607056,
-0.09796470403671265,
-0.3875654935836792,
0.3797738254070282,
0.07329031825065613,
-0.11079191416501999,
-0.5034200549125671,
0.08975932747125626,
0.36562424898147583,
0.31278446316719055,
-0.15399837493896484,
-0.5241291522979736,
0.01582190953195095,
0.20548692345619202,
-0.5009744167327881,
0.4795486629009247,
0.5380945205688477,
0.12022772431373596,
-0.5350489616394043,
0.3105369210243225,
-0.18491564691066742,
-0.2823881208896637,
0.05274360999464989,
-0.30723026394844055,
-0.6654170751571655,
0.6444693803787231,
-6.030087471008301,
-0.43329086899757385,
-0.6581504344940186,
0.3040003776550293,
-0.31829822063446045,
-0.051731448620557785,
1.0360941886901855,
-0.11992566287517548,
0.07473015785217285,
-0.054767414927482605,
0.1869628131389618,
0.32975006103515625,
-0.07301422953605652,
0.04877186566591263,
-0.21310243010520935,
0.13833889365196228,
-0.10248136520385742,
-0.281137615442276,
0.3962114453315735,
0.1510794758796692,
0.393984854221344,
-0.5077267289161682,
-0.28353044390678406,
0.5224573612213135,
-0.009722810238599777,
0.4075888991355896,
-1.0083087682724,
0.4089151620864868,
-0.3250718414783478,
-0.1454901099205017,
0.14725849032402039,
-0.3275814652442932,
-0.7120944261550903,
-0.3178514838218689,
0.1294471025466919,
0.1103336364030838,
0.2667490541934967,
-0.21946170926094055,
-0.1980222463607788,
-0.25881555676460266,
0.36154523491859436,
-0.09633442014455795,
-0.4428100883960724,
-0.3741450309753418,
0.28312358260154724,
-0.1225740909576416,
-0.07336615025997162,
0.28223517537117004,
-0.21175333857536316,
0.8489377498626709,
0.3185250759124756,
-0.2699204683303833,
0.0023664108011871576,
0.5575445890426636,
-0.00449341768398881,
-0.331204354763031,
0.18159572780132294,
0.3123333752155304,
-0.2484627068042755,
0.43962252140045166,
-0.02081076242029667,
0.011246487498283386,
0.13888715207576752,
-1.0273959636688232,
-0.418113648891449,
0.3934984803199768,
-0.7882933616638184,
-0.11339987814426422,
-0.15149429440498352,
-0.01798130013048649,
-0.4757632315158844,
0.5724705457687378,
0.10958368331193924,
-0.8625199198722839,
0.08432331681251526,
-0.26501280069351196,
0.21830597519874573,
-0.05799040570855141,
-0.3821842074394226,
-0.02994290553033352,
-0.0469825305044651,
-0.28298133611679077,
0.19748446345329285,
0.21055424213409424,
0.15553341805934906,
-0.3697311282157898,
-0.4180191159248352,
0.14212939143180847,
-0.1366816908121109,
0.06747302412986755,
0.2990029752254486,
-0.31069138646125793,
0.28134429454803467,
0.34945759177207947,
0.207550048828125,
0.3611753582954407,
0.3512113392353058,
0.363765150308609,
0.1760079264640808,
-0.05754382163286209,
0.17000535130500793,
-0.06051221862435341,
-0.08847159147262573,
-0.646910548210144,
0.03744940832257271,
0.19507652521133423,
-0.501743495464325,
-0.035418491810560226,
0.4076176881790161,
-0.4080880582332611,
0.40790751576423645,
-0.28923627734184265,
-0.32212793827056885,
-0.17668424546718597,
0.4066165089607239,
-0.020965801551938057,
0.006075289100408554,
-0.2680482566356659,
0.2786144018173218,
0.1362660527229309,
0.07374779880046844,
-0.16722902655601501,
-0.44924917817115784,
0.597840428352356,
-0.10965228825807571,
-0.6012041568756104,
0.05424634367227554,
0.7175382971763611,
-0.4771443009376526,
0.33818894624710083,
0.22227391600608826,
0.6173004508018494,
-0.1889117956161499,
0.018472446128726006,
0.3646606206893921,
-0.4869091212749481,
-0.37739595770835876,
0.1148257702589035,
0.28840720653533936,
-0.35861626267433167,
0.5526869893074036,
0.16054467856884003,
-0.14881974458694458,
0.14884386956691742,
-0.03295760229229927,
0.09653644263744354,
0.142978236079216,
-0.03187314048409462,
-0.20948299765586853,
0.18012911081314087,
0.15868504345417023,
-0.7527282238006592,
0.14149323105812073,
0.028684858232736588,
0.04647202789783478,
0.4833848476409912,
0.6293851733207703,
0.36199307441711426,
0.09948159754276276,
-0.461504727602005,
0.15393243730068207,
0.06429591774940491,
-0.9629261493682861,
-0.1369820535182953,
-0.11833493411540985,
-0.2904038429260254,
-0.25954514741897583,
0.08846088498830795,
0.051434002816677094,
0.3138982355594635,
-0.15212289988994598,
-0.6442402601242065,
0.13383151590824127,
-0.23466166853904724,
0.4028415381908417,
0.06135525181889534,
-0.20773957669734955,
0.06441100686788559,
-0.06915290653705597,
0.2373201698064804,
-0.06893542408943176,
-0.5607195496559143,
-0.6229249835014343,
0.5481204986572266,
0.6036679148674011,
0.9161986112594604,
-0.17543208599090576,
-0.5412916541099548,
-0.013444991782307625,
-0.27957215905189514,
0.07825922220945358,
0.3251411020755768,
-0.248154416680336,
0.18928802013397217,
0.05872366949915886,
-0.3818438649177551,
0.3135574460029602,
-0.01893232762813568,
-0.2370227873325348,
-0.22110280394554138,
-0.048660892993211746,
0.6714128255844116,
-0.21448315680027008,
0.330129474401474,
0.48586782813072205,
-0.2762988805770874,
-0.06915295124053955,
0.172118678689003,
-0.384551078081131,
-0.4808068871498108,
-0.02348649688065052,
-0.3718757927417755,
-0.01856842264533043,
0.3279142379760742,
-0.5050368905067444,
0.28321197628974915,
0.4144957959651947,
-0.4615723788738251,
-0.23836572468280792,
0.6390648484230042,
-0.1681702882051468,
-0.2197905331850052,
-0.08591064810752869,
-0.23823986947536469,
-0.39106062054634094,
0.2765580415725708,
0.5600377321243286,
-0.45500198006629944,
-0.17717325687408447,
0.08323365449905396,
-0.09132078289985657,
-0.00611861003562808,
0.2177930772304535,
0.1624293476343155,
0.11316632479429245,
-0.3049079179763794,
-0.4601731300354004,
0.22100627422332764,
-0.18445943295955658,
0.24349549412727356,
0.12868067622184753,
0.1844506412744522,
0.22009173035621643,
-0.35259321331977844,
-0.26242077350616455,
-0.32137632369995117,
0.39252275228500366,
-0.4531235098838806,
-0.2891741394996643,
0.1963387280702591,
0.15902507305145264,
-0.3052373230457306,
0.044617604464292526,
-0.14212541282176971,
0.8073186874389648,
0.7292050719261169,
-0.28886139392852783,
-0.7507984042167664,
-0.2659839391708374,
0.2352159023284912,
-0.2192286252975464,
0.3090516924858093,
0.001609325292520225,
-0.3348546624183655,
0.16099779307842255,
0.39018014073371887,
0.0738837793469429,
-0.5747575163841248,
0.18145084381103516,
-0.2579389214515686,
0.06395825743675232,
0.031985990703105927,
0.2689896821975708,
0.8055421710014343,
-0.10318858921527863,
0.1861822009086609,
-0.279060035943985,
0.33977800607681274,
0.034421488642692566,
-0.07026316970586777,
-0.25369611382484436,
-0.2983754575252533,
0.15595492720603943,
0.057587120682001114,
0.2377447634935379,
-0.3541751801967621,
0.06334767490625381,
0.1265556663274765,
-0.0010542933596298099,
-0.20948441326618195,
-0.1650177538394928,
0.21656149625778198,
-0.7173157334327698,
-0.23678408563137054,
-0.27368298172950745,
0.10118260234594345,
0.23832005262374878,
0.4704013466835022,
-0.2610083818435669,
-0.32813331484794617,
-0.28595367074012756,
0.5603379011154175,
0.45117080211639404,
-0.5674557685852051,
-0.04239592328667641,
0.12796370685100555,
0.29365333914756775,
0.0711091011762619,
0.27423030138015747,
0.12834501266479492,
0.4650803804397583,
-0.23111383616924286,
0.2044638693332672,
0.44428059458732605,
-0.6153133511543274,
0.093399778008461,
-0.31725451350212097,
-0.10623161494731903,
0.28557896614074707,
0.2554151713848114,
0.10535063594579697,
1.0894269943237305,
0.6694213151931763,
-0.03734777867794037,
-0.48436078429222107,
0.6454026103019714,
0.04564766213297844,
0.25007715821266174,
0.23659859597682953,
0.3942480683326721,
0.26734626293182373,
0.6381935477256775,
-0.2184857875108719,
0.6020575761795044,
0.3490658104419708,
0.10936497151851654,
0.053836721926927567,
-0.24073125422000885,
-0.09772659838199615,
-0.12438058853149414,
0.5587080717086792,
0.3646000027656555,
-0.18282434344291687,
-0.08082915842533112,
0.01827066019177437,
0.3454621136188507,
-0.2889782786369324,
0.4092501997947693,
0.34695667028427124,
0.05014848709106445,
0.134897381067276,
0.25638696551322937,
-0.4066767692565918,
0.2600094676017761,
-0.35376352071762085,
0.22204376757144928,
0.20657134056091309,
-0.570412814617157,
-0.49512389302253723,
0.32773590087890625,
0.05279302969574928,
0.47236061096191406,
-0.30754926800727844,
0.4905082881450653,
-0.19679208099842072,
-0.23251718282699585,
0.5572472810745239,
0.2699221968650818,
0.10102030634880066,
-0.29624509811401367,
0.03948702663183212,
0.004521024879068136,
-0.43438413739204407,
0.4580187499523163,
0.2945481836795807,
-0.3583454191684723,
-0.03492289036512375,
0.07566992193460464,
-0.1100134402513504,
0.447978138923645,
-0.3240000307559967,
0.08649957180023193,
-0.30401527881622314,
-0.4622304141521454,
-0.19539836049079895,
-0.08263866603374481,
-0.04208207130432129,
0.457091361284256,
0.635336697101593,
0.08258556574583054,
0.113274946808815,
-0.6644063591957092,
-0.20653662085533142,
-0.0007728006457909942,
-0.11185161769390106,
-0.2808268368244171,
-0.2480546534061432,
0.10821777582168579,
0.3394668698310852,
0.4524683654308319,
0.03372059762477875,
-0.43822771310806274,
0.22471030056476593,
0.7345760464668274,
-0.4242267608642578,
0.44284021854400635,
-0.08587784320116043,
0.018940843641757965,
-0.4504457712173462,
0.0228818878531456,
0.44990813732147217,
0.22246089577674866,
-0.3270680904388428,
0.14114485681056976,
-0.1711432933807373,
-0.10963425040245056,
0.17479003965854645,
-0.3890778422355652,
0.0024078809656202793,
-0.3411846458911896,
-0.20815497636795044,
-0.5467774271965027,
0.4973887503147125,
-0.14439168572425842,
-0.5540643334388733,
-0.26172685623168945,
0.27449288964271545,
0.2584283947944641,
0.2457813024520874,
0.4801599085330963,
0.03948963060975075,
0.49241289496421814,
-0.3657963275909424,
0.15008455514907837,
-0.8859938979148865,
0.06752723455429077,
-0.178827166557312,
-0.14510279893875122,
-0.1039886549115181,
-0.2627611458301544,
-0.1364997774362564,
-0.6262066960334778,
-0.22413405776023865,
0.15861012041568756,
0.3404325842857361,
0.36379945278167725,
-0.043961796909570694,
-0.3773868978023529,
-0.6335689425468445,
0.12444542348384857,
0.020507516339421272,
0.20948633551597595,
-0.39669516682624817,
-0.24392098188400269,
-0.21919889748096466,
-0.2083243578672409,
-0.18916746973991394,
-0.7898585200309753,
0.06435352563858032,
0.23656423389911652
] |
OBJECTIVE To evaluate the relative efficacy of programmed cell death 1 (PD-1) or programmed cell death ligand 1 (PD-L1) inhibitors versus conventional drugs in patients with cancer that were PD-L1 positive and PD-L1 negative. DESIGN Meta-analysis of randomised controlled trials. DATA SOURCES PubMed, Embase, Cochrane database, and conference abstracts presented at the American Society of Clinical Oncology and European Society of Medical Oncology up to March 2018. REVIEW METHODS Studies of PD-1 or PD-L1 inhibitors (avelumab, atezolizumab, durvalumab, nivolumab, and pembrolizumab) that had available hazard ratios for death based on PD-L1 positivity or negativity were included. The threshold for PD-L1 positivity or negativity was that PD-L1 stained cell accounted for 1% of tumour cells, or tumour and immune cells, assayed by immunohistochemistry staining methods. RESULTS 4174 patients with advanced or metastatic cancers from eight randomised controlled trials were included in this study. Compared with conventional agents, PD-1 or PD-L1 inhibitors were associated with significantly prolonged overall survival in both patients that were PD-L1 positive (n=2254, hazard ratio 0.66, 95% confidence interval 0.59 to 0.74) and PD-L1 negative (1920, 0.80, 0.71 to 0.90). However, the efficacies of PD-1 or PD-L1 blockade treatment in patients that were PD-L1 positive and PD-L1 negative were significantly different (P=0.02 for interaction). Additionally, in both patients that were PD-L1 positive and PD-L1 negative, the long term clinical benefits from PD-1 or PD-L1 blockade were observed consistently across interventional agent, cancer histotype, method of randomisation stratification, type of immunohistochemical scoring system, drug target, type of control group, and median follow-up time. CONCLUSIONS PD-1 or PD-L1 blockade therapy is a preferable treatment option over conventional therapy for both patients that are PD-L1 positive and PD-L1 negative. This finding suggests that PD-L1 expression status alone is insufficient in determining which patients should be offered PD-1 or PD-L1 blockade therapy. | [
0.012616729363799095,
0.020222486928105354,
-0.023390287533402443,
0.0016861094627529383,
-0.022721385583281517,
0.004603947047144175,
0.00908435508608818,
0.0007104177493602037,
-0.007853483781218529,
-0.015523349866271019,
-0.015080375596880913,
0.0031969966366887093,
0.008973105810582638,
0.014182545244693756,
0.00799641851335764,
0.006215850356966257,
-0.030834447592496872,
0.002132905414327979,
0.005820813123136759,
-0.0009532924741506577,
0.019482046365737915,
0.01814161241054535,
0.010061556473374367,
0.0028914217837154865,
-0.009193697944283485,
0.025651248171925545,
-0.01738819107413292,
-0.014049386605620384,
0.011055851355195045,
-0.018680132925510406,
-0.006495398469269276,
-0.009296433068811893,
0.017736636102199554,
-0.027606137096881866,
0.004635004326701164,
-0.012907658703625202,
0.0069850143045187,
0.007082771975547075,
-0.007553755771368742,
-0.005201350897550583,
0.008053830824792385,
-0.009749291464686394,
0.006459604948759079,
-0.039880383759737015,
-0.010376829653978348,
-0.007637177128344774,
-0.004860850051045418,
0.016800934448838234,
0.011247183196246624,
0.009299563243985176,
-0.01279949489980936,
0.004103308077901602,
-0.019587799906730652,
-0.029438313096761703,
-0.0059806788340210915,
0.018685324117541313,
0.02009953372180462,
-0.019798893481492996,
-0.014373507350683212,
0.013368183746933937,
0.022176126018166542,
-0.0495062917470932,
0.018876802176237106,
-0.0033692088909447193,
-0.006147307809442282,
-0.0670052245259285,
0.0009634282905608416,
0.019934089854359627,
-0.007262863218784332,
0.010601907968521118,
-0.0021393655333667994,
0.010692551732063293,
-0.006524146534502506,
-0.005759303458034992,
0.008009528741240501,
-0.028388170525431633,
-0.01199458446353674,
0.014872532337903976,
-0.0033561636228114367,
-0.008493083529174328,
0.003939101938158274,
-0.01319504901766777,
-0.006178092677146196,
0.028244368731975555,
-0.025625869631767273,
0.005428336560726166,
-0.01661504991352558,
-0.010581595823168755,
0.009654328227043152,
-0.022911667823791504,
-0.009774265810847282,
-0.03466109186410904,
-0.01954338327050209,
-0.010303674265742302,
-0.01182330958545208,
0.012242223136126995,
-0.027689440175890923,
-0.0014397096820175648,
0.00771654536947608,
-0.006807819940149784,
-0.02866806462407112,
-0.01330065168440342,
0.01704886183142662,
-0.026363898068666458,
-0.010404424741864204,
0.011961348354816437,
-0.02677217125892639,
0.0035413058940321207,
0.005327352322638035,
0.003795072203502059,
-0.013573221862316132,
0.0021441373974084854,
0.020588230341672897,
-0.003749983850866556,
0.0046329014003276825,
-0.01981801725924015,
0.004794425331056118,
-0.014323465526103973,
0.007833524607121944,
0.02051791176199913,
0.008807549253106117,
-0.010713386349380016,
-0.006798649672418833,
0.013190554454922676,
0.0029915759805589914,
-0.00008618435822427273,
0.026055801659822464,
-0.005620694253593683,
0.01957983896136284,
0.007618749048560858,
-0.01083412952721119,
-0.003669197205454111,
-0.028486670926213264,
-0.015474211424589157,
0.019951852038502693,
0.013377700001001358,
-0.0001361370086669922,
-0.0046600764617323875,
0.002843424677848816,
-0.005586131941527128,
-0.02706807851791382,
0.004314390476793051,
-0.0034950929693877697,
0.02254621312022209,
-0.015867818146944046,
0.018816575407981873,
-0.015460571274161339,
-0.012521572411060333,
-0.0021513456013053656,
0.015267560258507729,
0.008135618641972542,
-0.0018465279135853052,
-0.0030319932848215103,
-0.013678434304893017,
0.012366272509098053,
0.0015580665785819292,
-0.01609572023153305,
-0.019451681524515152,
-0.027672428637742996,
0.005241876468062401,
-0.01415854413062334,
-0.009233560413122177,
-0.002773830434307456,
0.009497484192252159,
0.0030350778251886368,
0.010120182298123837,
-0.05488826334476471,
-0.017999431118369102,
-0.01586741767823696,
0.0019826225470751524,
-0.0024235143791884184,
0.017795110121369362,
-0.03221858665347099,
0.00983353704214096,
-0.01063501089811325,
-0.0028253216296434402,
0.0043471138924360275,
0.009179327636957169,
-0.00724645983427763,
0.06623219698667526,
0.005008960608392954,
-0.004806500393897295,
0.009017348289489746,
-0.000060653313994407654,
0.004333552438765764,
-0.01316017471253872,
0.007945175282657146,
-0.007037552073597908,
-0.0037120776250958443,
-0.00014350004494190216,
0.01928568072617054,
-0.007102186791598797,
-0.032034389674663544,
-0.011090867221355438,
-0.026446441188454628,
0.0016991638112813234,
-0.012525899335741997,
0.009403374046087265,
0.001882883720099926,
-0.004148547071963549,
0.022696997970342636,
0.0070030870847404,
0.011388063430786133,
-0.03729342669248581,
-0.01718718558549881,
0.014308858662843704,
-0.015580413863062859,
-0.04225924611091614,
0.02374132163822651,
0.0002924492582678795,
0.02270033210515976,
0.013876164332032204,
-0.0017182152951136231,
0.003050610888749361,
0.010561205446720123,
-0.0007847779197618365,
-0.029932966455817223,
-0.0130251944065094,
-0.025944210588932037,
-0.014521028846502304,
0.002192338230088353,
0.017056599259376526,
0.022482063621282578,
0.013877833262085915,
0.0028569120913743973,
-0.03901277482509613,
-0.009272962808609009,
0.005898871924728155,
0.02165106311440468,
-0.004043084569275379,
-0.01290135644376278,
0.019965313374996185,
-0.014746556989848614,
-0.009773488156497478,
0.018019529059529305,
0.022643521428108215,
0.013847504742443562,
-0.03370717167854309,
0.015290247276425362,
-0.010079186409711838,
-0.02135210670530796,
-0.009270941838622093,
0.027359364554286003,
0.009473484940826893,
0.032046496868133545,
-0.019807683303952217,
0.02427353896200657,
0.027703914791345596,
-0.016794385388493538,
0.00022618123330175877,
0.008641552180051804,
-0.023617414757609367,
0.01203690841794014,
-0.006846158765256405,
0.008181970566511154,
-0.0007320917211472988,
-0.01803622953593731,
-0.010391540825366974,
0.022936727851629257,
-0.02697695419192314,
-0.005627280101180077,
0.004807225428521633,
0.024645667523145676,
-0.024527214467525482,
0.00048780941870063543,
-0.0023998557589948177,
-0.002655311953276396,
0.011622406542301178,
0.007548912428319454,
-0.020110411569476128,
0.012522478587925434,
-0.010150736197829247,
-0.0023866621777415276,
-0.0813978761434555,
-0.01734316535294056,
-0.020731499418616295,
0.0245182104408741,
0.0063136545941233635,
-0.0012101298198103905,
0.017757641151547432,
0.00594079215079546,
-0.015136091969907284,
-0.02677694335579872,
-0.01738741621375084,
0.03876675292849541,
-0.006814757827669382,
-0.02397492155432701,
-0.008147154934704304,
-0.008705012500286102,
0.010684320703148842,
-0.008447862230241299,
-0.0037115898448973894,
-0.03303271904587746,
0.0051834434270858765,
-0.027134213596582413,
0.023558959364891052,
-0.0013002571649849415,
-0.0015557350125163794,
0.030347514897584915,
0.010819603689014912,
0.028970681130886078,
-0.01686011254787445,
0.002666865475475788,
0.0024707128759473562,
-0.04327522590756416,
-0.020517095923423767,
-0.002947237342596054,
-0.006745804101228714,
-0.009995070286095142,
0.001695146318525076,
0.007869405671954155,
-0.02622978761792183,
0.03094153106212616,
-0.004404644947499037,
0.009872747585177422,
-0.009630219079554081,
-0.0020194221287965775,
0.010359518229961395,
0.015568044036626816,
-0.02112080156803131,
0.02338802069425583,
0.01157816406339407,
-0.0038635442033410072,
-0.009470532648265362,
-0.0016957391053438187,
0.006832311395555735,
0.0190705806016922,
0.00011571869254112244,
-0.01063824538141489,
-0.0032718447037041187,
-0.0009858226403594017,
-0.012609461322426796,
-0.01741817221045494,
-0.01199084147810936,
-0.019306965172290802,
0.013707153499126434,
-0.011143376119434834,
-0.019506148993968964,
0.007201546803116798,
0.013285480439662933,
-0.01584765687584877,
-0.008489519357681274,
0.025366879999637604,
0.001817440614104271,
-0.022797517478466034,
-0.011607605032622814,
-0.008562063798308372,
-0.010435478761792183,
-0.014126299880445004,
-0.013442778028547764,
-0.013660606928169727,
0.01903415098786354,
0.01214330829679966,
0.0002629905939102173,
-0.01270873099565506,
-0.011020762845873833,
0.006960669532418251,
-0.009336593560874462,
-0.012519015930593014,
0.004254900850355625,
0.005113490857183933,
0.01699043996632099,
-0.016785111278295517,
0.01776617020368576,
0.011089630424976349,
0.016871348023414612,
0.015211320482194424,
-0.024430222809314728,
-0.03318305313587189,
-0.00429930817335844,
0.01593407429754734,
0.01637541502714157,
0.006879451684653759,
-0.023084159940481186,
-0.00452400790527463,
-0.0387837290763855,
-0.013382162898778915,
-0.03705357760190964,
0.009503040462732315,
0.001349056139588356,
-0.002697231015190482,
-0.020184140652418137,
-0.005393797066062689,
-0.04228721559047699,
-0.0069513944908976555,
-0.007864181883633137,
0.03633328154683113,
0.00808035209774971,
-0.0010461854981258512,
-0.006248760968446732,
0.009572234004735947,
0.07221271097660065,
0.010446418076753616,
0.0069776237942278385,
-0.010547101497650146,
0.014709720388054848,
-0.020480044186115265,
-0.014441389590501785,
0.025358114391565323,
0.01234650332480669,
0.00770121905952692,
0.011047556065022945,
-0.0066484324634075165,
0.022880086675286293,
0.008607273921370506,
-0.0005517648532986641,
-0.006367707625031471,
-0.03685557097196579,
-0.004432849586009979,
0.038031987845897675,
-0.029723279178142548,
-0.003957759588956833,
-0.016120148822665215,
-0.0005092842038720846,
-0.020899510011076927,
-0.0034228931181132793,
-0.010242002084851265,
0.009970257058739662,
-0.01526736281812191,
-0.044010553508996964,
0.007250632159411907,
-0.013710016384720802,
0.0008971957140602171,
-0.006078486796468496,
-0.001131854485720396,
0.017651209607720375,
0.024007638916373253,
0.004407037049531937,
-0.02805585414171219,
0.004129844717681408,
0.00958240032196045,
-0.01676785945892334,
-0.013731250539422035,
-0.015966208651661873,
0.002744517754763365,
-0.00404235627502203,
0.0137013029307127,
0.0047265151515603065,
-0.008778126910328865,
-0.012286864221096039,
0.006873952690511942,
-0.008909119293093681,
-0.012013274244964123,
0.01485615037381649,
-0.0004235291853547096,
-0.012162329629063606,
-0.013744723983108997,
0.0023336955346167088,
0.004549772012978792,
-0.023166056722402573,
-0.010072378441691399,
-0.004280515946447849,
0.005515221040695906,
0.01875333860516548,
-0.015528867021203041,
0.0017623158637434244,
-0.020482856780290604,
-0.008694265969097614,
-0.02511342614889145,
-0.019145488739013672,
-0.030569257214665413,
-0.0014032057952135801,
-0.004277681931853294,
-0.0002820892259478569,
0.017766671255230904,
-0.007109645288437605,
0.022472675889730453,
0.01162607129663229,
-0.00983726978302002,
-0.03071047179400921,
-0.014356879517436028,
-0.010987957939505577,
-0.0008680112659931183,
0.0088270865380764,
-0.03292851895093918,
-0.012718994170427322,
0.020868195220828056,
-0.005882227327674627,
-0.07465699315071106,
-0.04295043647289276,
0.024760577827692032,
-0.009601728990674019,
-0.04088257998228073,
0.051742807030677795,
-0.007658523507416248,
-0.0014330693520605564,
-0.009703584015369415,
0.0007315946859307587,
-0.018749570474028587,
-0.007769353222101927,
-0.0071271806955337524,
-0.0049669332802295685,
0.015113281086087227,
0.018753021955490112,
0.010907093062996864,
-0.003740259911864996,
-0.012962144799530506,
-0.03142709657549858,
0.0047347284853458405,
-0.011245864443480968,
-0.0564548596739769,
-0.014777506701648235,
-0.003935619723051786,
-0.0809488296508789,
0.014191266149282455,
-0.016867969185113907,
-0.020770981907844543,
-0.0008759996853768826,
-0.014963884837925434,
0.034295208752155304,
-0.01294005662202835,
-0.003338488284498453,
-0.015296007506549358,
0.013782118447124958,
-0.003184275468811393,
0.014979555271565914,
0.007761601358652115,
-0.00958927720785141,
0.0005655739223584533,
0.012341950088739395,
-0.027901072055101395,
0.02525193989276886,
0.005551490001380444,
-0.001283364836126566,
0.01806790567934513,
-0.007459728978574276,
0.008705229498445988,
-0.009463341906666756,
-0.03888046741485596,
-0.01081063598394394,
0.01541643775999546,
-0.0028937042225152254,
-0.030401553958654404,
0.006401882506906986,
-0.03854621201753616,
-0.007140582427382469,
-0.003167279064655304,
-0.027393758296966553,
-0.014935404062271118,
-0.0009983298368752003,
0.019420616328716278,
0.004031416028738022,
-0.006189469248056412,
0.0002077691606245935,
0.03326015919446945,
0.011373171582818031,
0.012740769423544407,
0.015363289043307304,
-0.004573937971144915,
0.0054727764800190926,
-0.010922260582447052,
0.011401316151022911,
-0.024296876043081284,
0.0029138985555619,
-0.014612732455134392,
-0.008763482794165611,
0.003056000452488661,
-0.011944732628762722,
-0.022563006728887558,
-0.010447783395648003,
0.0021683964878320694,
0.02400931529700756,
0.008860456757247448,
-0.003127003088593483,
0.02881469391286373,
-0.01437131967395544,
0.0716322734951973,
-0.030833635479211807,
0.013933641836047173,
0.003404616843909025,
-0.01473319437354803,
0.0004391508409753442,
0.002698006108403206,
-0.01479796040803194,
-0.011545724235475063,
-0.017573796212673187,
0.004396610893309116,
-0.011408992111682892,
0.025090720504522324,
0.007383855991065502,
0.004879798740148544,
0.013368107378482819,
0.022638333961367607,
0.01702609658241272,
0.0021024513989686966,
0.009440304711461067,
0.014306344091892242,
0.01819501630961895,
-0.02090420201420784,
-0.016354875639081,
0.012122773565351963,
-0.025515558198094368,
-0.0107096116989851,
0.000021120300516486168,
-0.008218135684728622,
-0.022789113223552704,
0.012095492333173752,
-0.01730411872267723,
0.000449801969807595,
-0.0037526004016399384,
0.015305780805647373,
0.004998244810849428,
-0.012961742468178272,
0.013713781721889973,
-0.023200221359729767,
-0.011172161437571049,
0.03349938988685608,
0.0033915676176548004,
-0.0026863180100917816,
0.0014613056555390358,
0.005054723937064409,
0.00027442805003374815,
-0.012413037940859795,
-0.0046788668259978294,
0.01084958016872406,
0.003220735117793083,
0.019461732357740402,
-0.0013322532176971436,
0.01262716669589281,
-0.005257646553218365,
0.003701165784150362,
0.005502547137439251,
-0.012833686545491219,
0.017327360808849335,
-0.021000666543841362,
-0.03026939183473587,
0.020067889243364334,
-0.021688297390937805,
0.005025223363190889,
-0.015311921015381813,
0.03803534805774689,
0.010331991128623486,
0.03257586807012558,
-0.022915760055184364,
0.0009005493484437466,
0.009085007011890411,
-0.002043019514530897,
0.015429453924298286,
0.006165690254420042,
0.016960009932518005,
0.01044786162674427,
0.011419465765357018,
0.039274781942367554,
0.015541714616119862,
0.006535787135362625,
-0.014296953566372395,
0.0011288027744740248,
0.004607511684298515,
0.024329418316483498,
0.021715844050049782,
-0.04037003964185715,
0.02766290493309498,
0.04573335498571396,
0.02370169386267662,
-0.007161262445151806,
0.0005840720841661096,
0.028783543035387993,
-0.0006448891945183277,
0.0063536809757351875,
-0.011385506018996239,
0.006470239255577326,
0.03309289366006851,
-0.010401385836303234,
0.004193219356238842,
0.037366122007369995,
-0.006966947112232447,
-0.017109867185354233,
0.01752314157783985,
-0.011579975485801697,
0.00036532036028802395,
0.018114885315299034,
0.007301965728402138,
-0.00871685054153204,
-0.018135160207748413,
0.008983534760773182,
0.03459545597434044,
-0.02719154953956604,
-0.003764993278309703,
0.03239132836461067,
-0.0028918907046318054,
0.03210350498557091,
0.0318806916475296,
-0.0066844392567873,
-0.029466411098837852,
-0.001856151269748807,
-0.019520360976457596,
-0.019833488389849663,
0.0011108136968687177,
-0.004965248517692089,
0.013241218402981758,
-0.0012726320419460535,
-0.022187715396285057,
-0.006153973750770092,
0.007085230201482773,
0.004770740866661072,
-0.008914608508348465,
0.008195983245968819,
0.002063810359686613,
-0.025317929685115814,
0.007497106678783894,
0.0061886971816420555,
0.003350000362843275,
-0.0035064052790403366,
-0.00108057027682662,
-0.005239561665803194,
0.009563283994793892,
0.0037721628323197365,
-0.014482161961495876,
-0.003237080527469516,
-0.009506427682936192,
0.0092807337641716,
-0.01579565741121769,
0.009943122044205666,
0.0138558866456151,
0.003845533588901162,
0.00549036031588912,
0.005770327523350716,
0.026395665481686592,
-0.0036234466824680567,
-0.003270728513598442,
0.0023898715153336525,
0.0036278304178267717,
0.016833951696753502,
0.004224545322358608,
0.02026389166712761,
-0.010033690370619297,
0.005518888123333454,
0.0035913726314902306,
-0.0007632500492036343,
-0.0013598091900348663,
-0.0092131607234478,
0.01216983888298273,
0.00005561532452702522,
0.004419645760208368,
0.011820172891020775,
-0.009466612711548805,
0.03728194162249565,
-0.026315266266465187,
-0.0013077463954687119,
-0.00009928038343787193,
-0.024184618145227432,
-0.0022289957851171494,
0.004747180268168449,
-0.0009830668568611145,
0.0076309144496917725,
0.01889968104660511,
0.027784783393144608,
-0.018530461937189102,
-0.011504346504807472,
-0.010544252581894398,
-0.02350238896906376,
0.022846538573503494,
0.004096864257007837,
0.006010239012539387,
0.014354372397065163,
0.0340375155210495,
-0.003640650073066354,
-0.0001022616634145379,
-0.014711876399815083,
0.014138922095298767,
-0.00838370993733406,
-0.0069762710481882095,
0.021810023114085197,
-0.02597084641456604,
0.004621545784175396,
-0.01629297435283661,
0.03671479597687721,
-0.024713566526770592
] | [
0.09758204966783524,
-0.1733042150735855,
0.23957647383213043,
0.03179315850138664,
0.07285786420106888,
0.2595822811126709,
0.12966614961624146,
-0.5407980680465698,
0.0323338657617569,
-0.20807170867919922,
0.19571185111999512,
0.810657799243927,
-0.3204229176044464,
-0.057270508259534836,
0.23107805848121643,
1.1810041666030884,
0.5116859674453735,
0.04998679831624031,
0.1702803671360016,
-0.6011017560958862,
0.0282666627317667,
-0.3057026267051697,
0.109568752348423,
-0.2532144784927368,
-0.05646562576293945,
0.25382354855537415,
0.46668824553489685,
-0.07457586377859116,
-0.09630480408668518,
-0.27428436279296875,
-0.22311681509017944,
0.5219421982765198,
0.02113530784845352,
-0.3568166494369507,
-0.11380849778652191,
0.5024670362472534,
-0.04404772073030472,
0.23382486402988434,
0.09451267123222351,
-0.40270718932151794,
-0.48887330293655396,
-0.15094567835330963,
-0.433483749628067,
0.5842046737670898,
-0.3078204095363617,
-0.23769760131835938,
-1.629555106163025,
-0.09561412036418915,
-0.274509459733963,
0.3220050036907196,
0.31637683510780334,
0.4098195731639862,
-0.04553085193037987,
0.11272996664047241,
0.4639887511730194,
0.6821847558021545,
-0.22256694734096527,
-0.6167094111442566,
-0.013488470576703548,
-0.10878729075193405,
-0.12366963922977448,
-0.16105327010154724,
-0.029914237558841705,
0.42061474919319153,
0.0477580800652504,
0.6182738542556763,
-0.020847875624895096,
-0.2283192276954651,
-0.680576741695404,
-0.22714172303676605,
-0.009122254326939583,
-0.27842968702316284,
-0.3841003179550171,
0.28360527753829956,
-0.2900395691394806,
-0.6090729832649231,
-0.10083266347646713,
0.12253481894731522,
0.3146913945674896,
0.26604729890823364,
0.7363445162773132,
0.011196230538189411,
0.0866798609495163,
-0.33730176091194153,
0.04222334548830986,
0.44731950759887695,
0.008198566734790802,
0.24929675459861755,
-0.4905024766921997,
0.032086342573165894,
-0.06411907076835632,
-0.3571922183036804,
0.28735172748565674,
0.7105053663253784,
0.16692394018173218,
0.08942953497171402,
-0.08001238852739334,
0.032632388174533844,
-0.034412238746881485,
0.25534868240356445,
0.13495849072933197,
0.16558711230754852,
-0.1893322914838791,
-0.21063515543937683,
-0.636323869228363,
-0.13601994514465332,
-0.433808833360672,
-0.9814001321792603,
-1.0331519842147827,
0.28060176968574524,
-0.7497228980064392,
0.804602861404419,
-0.243907168507576,
-0.14778733253479004,
-0.44455957412719727,
0.14591707289218903,
0.2598123550415039,
-0.42540228366851807,
0.018328838050365448,
0.5009235739707947,
0.16325953602790833,
1.1761441230773926,
0.050294362008571625,
0.641349732875824,
-0.0008879780070856214,
0.037625592201948166,
0.4777962267398834,
0.09081962704658508,
0.2844841778278351,
0.7648118734359741,
0.20280371606349945,
0.21794846653938293,
-0.5710635781288147,
-0.07862615585327148,
-0.11537007987499237,
-0.29028016328811646,
0.3172284960746765,
-0.24696096777915955,
0.1680271178483963,
0.0004447059181984514,
-0.6804474592208862,
-0.7929033637046814,
-0.08241235464811325,
-0.2758706510066986,
0.08707114309072495,
-0.39887526631355286,
0.3547247648239136,
0.43182432651519775,
-0.3991142809391022,
-0.0343891978263855,
0.0105936573818326,
0.0032470221631228924,
-0.6052910685539246,
-0.25351816415786743,
0.07693038135766983,
0.6884458065032959,
-0.49844005703926086,
-0.4224705100059509,
-0.01573828235268593,
0.024560099467635155,
0.46574220061302185,
0.4258277714252472,
-0.38688352704048157,
-0.24180695414543152,
0.24132497608661652,
-0.26447436213493347,
0.3583229184150696,
0.08580495417118073,
0.5507295727729797,
-0.07971544563770294,
-0.3048642575740814,
-0.5974434018135071,
0.000854013953357935,
-0.5500480532646179,
-0.04656730592250824,
-0.1646953821182251,
0.5307758450508118,
0.005584270227700472,
0.05201619118452072,
0.12999078631401062,
-0.6432955861091614,
0.0959661453962326,
-0.21137112379074097,
-0.8124589920043945,
-0.062372684478759766,
0.30790141224861145,
0.7084174156188965,
0.19409306347370148,
0.5105334520339966,
0.5699501037597656,
-0.18794208765029907,
0.013604778796434402,
0.20418228209018707,
-0.7752140760421753,
1.3930401802062988,
-0.4576641917228699,
-0.489667683839798,
1.1799001693725586,
-0.07235746830701828,
-0.06410010904073715,
0.1199411153793335,
0.30340301990509033,
0.36835750937461853,
-0.2940387725830078,
-0.5949090123176575,
-0.36788100004196167,
0.12397703528404236,
-0.34148019552230835,
-0.6250367760658264,
0.6369459629058838,
0.639194905757904,
-0.41890737414360046,
-0.42393723130226135,
-0.20293033123016357,
0.3458007574081421,
0.12642386555671692,
0.09695897251367569,
0.37519371509552,
-0.2049103081226349,
-0.12796616554260254,
0.5046988129615784,
-0.6108155846595764,
0.4089527130126953,
0.6598034501075745,
0.09509238600730896,
0.7031981348991394,
0.3670184910297394,
-0.2114853411912918,
0.484571248292923,
-0.7032219171524048,
0.3998399078845978,
-0.04259660840034485,
0.5435431599617004,
-0.5497634410858154,
0.1625029295682907,
0.18357840180397034,
-0.1582963764667511,
-0.30243149399757385,
0.6092614531517029,
0.10671843588352203,
0.073609359562397,
-0.03882875293493271,
0.048449017107486725,
0.09822766482830048,
0.5587955117225647,
-0.39739876985549927,
-0.11170990765094757,
0.33415475487709045,
-0.845515787601471,
-0.18595503270626068,
0.0032523784320801497,
-0.1567612737417221,
0.06665098667144775,
-0.2211417555809021,
0.205743208527565,
0.26586055755615234,
-0.3134191632270813,
-0.5140883922576904,
-0.06439751386642456,
-0.0840461254119873,
-0.391706645488739,
0.14958113431930542,
0.42283281683921814,
-0.05949060991406441,
0.5199852585792542,
-0.5087772607803345,
-0.6825719475746155,
-0.28753307461738586,
0.41906729340553284,
0.7133040428161621,
0.6830559372901917,
0.3664546310901642,
-0.48599445819854736,
-0.04584090784192085,
-0.10272136330604553,
-0.3405044972896576,
0.003332337597385049,
0.7835170030593872,
-0.9952205419540405,
-0.6250371336936951,
0.42743268609046936,
-0.022707676514983177,
0.47031280398368835,
-0.02210763841867447,
-0.3905009329319,
-0.40613237023353577,
-0.1829875409603119,
-0.6216802000999451,
-0.5612645745277405,
-0.25087103247642517,
-0.13480594754219055,
0.7117413282394409,
-0.6798108220100403,
-0.41369369626045227,
0.05760902911424637,
0.08349786698818207,
-0.2208685576915741,
0.48754793405532837,
0.4624205231666565,
-0.41865551471710205,
0.1286858171224594,
-0.07399433851242065,
-0.1259409338235855,
-0.09439269453287125,
0.2519169747829437,
-0.26890018582344055,
-0.05867224186658859,
0.11092396080493927,
-5.87241268157959,
-0.180380180478096,
-0.7756125330924988,
0.37340325117111206,
-0.21956422924995422,
-0.04303815960884094,
1.0000553131103516,
0.08895234018564224,
0.21537072956562042,
-0.15444639325141907,
0.3229488432407379,
0.2659000754356384,
0.3825606107711792,
0.2107151299715042,
-0.09703494608402252,
0.6863409876823425,
0.301676481962204,
0.08337782323360443,
0.6221935749053955,
0.18864762783050537,
0.2496238797903061,
-0.4791790843009949,
-0.2592802941799164,
0.25004029273986816,
0.3039436638355255,
-0.04177812486886978,
-1.072656273841858,
0.6988609433174133,
0.24142177402973175,
-0.1678837388753891,
0.3431338965892792,
-0.244239941239357,
-0.45205506682395935,
-0.43259578943252563,
0.2477092444896698,
0.2050425112247467,
0.17507176101207733,
-0.14083349704742432,
-0.0685572475194931,
-0.2310807853937149,
0.3150034248828888,
0.24380311369895935,
-0.34479424357414246,
-0.1946718841791153,
0.01727689988911152,
0.0508694127202034,
0.24079634249210358,
0.6103147864341736,
-0.0031076513696461916,
0.2817656397819519,
0.20988041162490845,
-0.03944320231676102,
0.1707693338394165,
0.9759340882301331,
0.19712591171264648,
-0.22520571947097778,
-0.10967613011598587,
0.1852305680513382,
-0.5230721235275269,
0.6100521087646484,
0.06712909787893295,
-0.12463758140802383,
-0.2880367636680603,
-0.7886030673980713,
-0.24831520020961761,
0.3282928764820099,
-0.14551307260990143,
-0.6570361852645874,
0.17240819334983826,
-0.056558556854724884,
-0.09307871758937836,
0.2344624400138855,
0.037247318774461746,
-0.6698873043060303,
0.21343868970870972,
-0.21253015100955963,
0.6440744996070862,
0.25885599851608276,
-0.5178037285804749,
0.04951440915465355,
-0.5757763385772705,
-0.5937726497650146,
0.12191344797611237,
0.2264711558818817,
0.29607340693473816,
-0.1123410016298294,
-0.03663451969623566,
0.4463179409503937,
-0.26407384872436523,
0.30299898982048035,
0.21556761860847473,
-0.17198416590690613,
0.3706713020801544,
0.8154661655426025,
-0.08170133829116821,
0.15842632949352264,
0.7081953287124634,
0.39067721366882324,
0.4723738431930542,
-0.048058029264211655,
0.5253247618675232,
0.3424304127693176,
0.06320903450250626,
-1.0542924404144287,
-0.040288783609867096,
-0.04582439735531807,
-0.6208041310310364,
-0.3793098032474518,
0.8784699440002441,
-1.035792589187622,
0.08153554797172546,
-0.03653400391340256,
-0.08287054300308228,
0.27169856429100037,
0.6616894602775574,
-0.027372097596526146,
0.033700425177812576,
0.06371550261974335,
0.18409933149814606,
-0.17922177910804749,
-0.31080949306488037,
0.18004539608955383,
-0.6718810200691223,
0.07043173909187317,
-0.1570841521024704,
-0.4453331530094147,
-0.03353137522935867,
0.6745649576187134,
-0.3886590600013733,
0.22675956785678864,
0.3491884469985962,
0.7837639451026917,
-0.6236787438392639,
-0.16728828847408295,
0.048519957810640335,
-0.6217743158340454,
-0.5869846940040588,
0.276202529668808,
0.5052209496498108,
0.06931306421756744,
0.19886136054992676,
-0.18972337245941162,
0.023269299417734146,
0.0019854020792990923,
0.08070505410432816,
-0.19533394277095795,
0.11235740035772324,
-0.17261764407157898,
-0.4502309262752533,
0.09986934810876846,
0.2945761978626251,
0.05792733281850815,
0.31188440322875977,
-0.057865798473358154,
-0.04081176593899727,
0.18848374485969543,
0.6217994689941406,
0.040299057960510254,
0.11953799426555634,
-0.5053329467773438,
0.47056350111961365,
0.17225240170955658,
-0.5880683064460754,
-0.27212637662887573,
0.2274804264307022,
-0.15219151973724365,
-0.1527746468782425,
0.07174833118915558,
0.17313721776008606,
0.1541542261838913,
0.0961054116487503,
-0.7135582566261292,
-0.09394872188568115,
-0.265845388174057,
0.04235897585749626,
0.19514520466327667,
-0.41557058691978455,
-0.045309096574783325,
-0.20307312905788422,
0.0075606429018080235,
0.13076062500476837,
-1.0243949890136719,
-0.29678115248680115,
0.10205284506082535,
0.7703522443771362,
0.18993405997753143,
-0.0007823049672879279,
-0.4304712414741516,
-0.2103811502456665,
-0.3580888509750366,
-0.21588115394115448,
0.13436827063560486,
0.7350700497627258,
-0.24493402242660522,
-0.3965136706829071,
-0.5036373734474182,
0.185511976480484,
0.21460741758346558,
-0.0288550965487957,
-0.5954151153564453,
0.10693623125553131,
0.5610702633857727,
-0.09717123210430145,
0.3306637704372406,
0.05657200887799263,
-0.509397566318512,
-0.5056228637695312,
0.13930290937423706,
-0.14085248112678528,
0.02547512575984001,
-0.18927595019340515,
-0.9285649657249451,
0.13277322053909302,
0.5003114938735962,
-0.2408701777458191,
0.1565466970205307,
0.0009195122984237969,
-0.06530453264713287,
-0.326200932264328,
0.17527209222316742,
0.5654609799385071,
-0.07159844040870667,
-0.19312314689159393,
0.02997014857828617,
-0.45810890197753906,
0.03563546761870384,
0.8576852083206177,
-1.025070309638977,
0.2678312063217163,
0.08602789044380188,
-0.49992993474006653,
0.04219083487987518,
-0.2461490035057068,
-0.1711624711751938,
-0.3449850082397461,
-0.20039215683937073,
-0.46763038635253906,
0.28606125712394714,
0.24361585080623627,
-0.13117042183876038,
-0.39087599515914917,
0.5915138721466064,
-0.1614774912595749,
-0.16863495111465454,
0.11491706222295761,
0.4045023024082184,
0.06880377978086472,
-0.5252891778945923,
-0.868850588798523,
0.17182886600494385,
-0.03570755571126938,
-0.23207330703735352,
0.24413053691387177,
-0.05637761950492859,
1.2131115198135376,
0.33196723461151123,
-0.19875580072402954,
0.025203941389918327,
-0.5855153799057007,
0.467822790145874,
-0.2652149796485901,
-0.2047426998615265,
-0.4611636996269226,
-0.3344372808933258,
-0.021401425823569298,
-0.011485542170703411,
0.1038203239440918,
-0.5547001957893372,
0.21057818830013275,
-0.25026431679725647,
-0.2114022821187973,
-0.13871903717517853,
0.443871408700943,
0.7811038494110107,
0.13575796782970428,
0.17870229482650757,
-0.07805662602186203,
-0.08734917640686035,
-0.12923605740070343,
0.07683433592319489,
-0.2253911942243576,
-0.30705663561820984,
0.5227863192558289,
-0.38338130712509155,
0.20528168976306915,
-0.5960756540298462,
0.20858070254325867,
0.15276013314723969,
-0.09061823785305023,
-0.47119441628456116,
0.15660294890403748,
0.17012687027454376,
-0.759724497795105,
-0.6258222460746765,
-0.39281165599823,
0.5201399326324463,
0.0256452988833189,
0.16747929155826569,
0.14028790593147278,
-0.40578535199165344,
0.05341028794646263,
0.7766188979148865,
0.66844242811203,
-0.4147353172302246,
-0.2077932357788086,
0.6097951531410217,
0.46743330359458923,
0.15176217257976532,
-0.10687106102705002,
-0.03308382257819176,
0.23400652408599854,
-0.07877112179994583,
0.607799768447876,
0.679099440574646,
-0.41164496541023254,
0.3666091561317444,
-0.31725481152534485,
0.03021407313644886,
0.5939502120018005,
0.28341054916381836,
0.33999037742614746,
0.3395094573497772,
0.7163875102996826,
-0.13651275634765625,
-0.4737294316291809,
0.09925238788127899,
-0.011518512852489948,
0.4305863678455353,
0.10578517615795135,
0.3610289692878723,
0.5699643492698669,
0.23760952055454254,
-0.03942544385790825,
0.44141870737075806,
-0.073759526014328,
0.5308931469917297,
-0.1557987481355667,
-0.32251280546188354,
-0.4472014307975769,
0.02205839566886425,
0.9022340178489685,
0.44652652740478516,
-0.15930713713169098,
-0.08977796882390976,
-0.015520135872066021,
0.5717136859893799,
-0.019410300999879837,
0.09285164624452591,
-0.5036970376968384,
0.2739912271499634,
-0.16792450845241547,
0.13339798152446747,
-0.43289223313331604,
-0.04150110483169556,
-0.7155727744102478,
-0.028977783396840096,
0.3588598668575287,
-0.394980788230896,
-0.12002088129520416,
0.14525893330574036,
-0.0862678661942482,
0.3566460609436035,
-0.22076819837093353,
0.5328323841094971,
-0.9219620227813721,
-0.1769176870584488,
0.4922349750995636,
0.26772820949554443,
0.0456511490046978,
-0.03233902156352997,
-0.05277597904205322,
-0.04124053195118904,
-0.07103341072797775,
0.4122217297554016,
0.17296256124973297,
-0.37896233797073364,
0.06902993470430374,
-0.2814754843711853,
-0.14038635790348053,
0.22162793576717377,
-0.19539517164230347,
-0.31787630915641785,
-0.2574739158153534,
-0.23343266546726227,
-0.30178385972976685,
-0.1134793609380722,
-0.49565547704696655,
0.2682187259197235,
0.3719384968280792,
-0.0536000058054924,
-0.22770392894744873,
-0.24002307653427124,
0.2828280031681061,
0.19927242398262024,
-0.1831752359867096,
-0.23040302097797394,
-0.1366342008113861,
0.29613298177719116,
-0.07185633480548859,
0.40393969416618347,
-0.20733767747879028,
0.10826467722654343,
-0.041489940136671066,
0.5284354090690613,
-0.2467530369758606,
0.6626709699630737,
-0.829618513584137,
0.4659799635410309,
-0.6049513816833496,
0.01162341982126236,
0.5629649758338928,
0.22255326807498932,
-0.27833089232444763,
0.019191844388842583,
-0.07724110782146454,
-0.18893392384052277,
0.2790989577770233,
-0.3410281240940094,
0.17117737233638763,
0.09267602115869522,
0.033538106828927994,
-0.30251291394233704,
0.15199768543243408,
-0.11605792492628098,
-0.9443206787109375,
0.013862773776054382,
0.25550752878189087,
0.2155073583126068,
0.036354243755340576,
0.23316311836242676,
-0.19334396719932556,
-0.25085219740867615,
-0.18673603236675262,
0.17304451763629913,
-0.9569007158279419,
-0.03724798187613487,
-0.0927305519580841,
0.3089039921760559,
0.2428010106086731,
-0.027731861919164658,
-0.2152353674173355,
-0.08992667496204376,
0.4202805757522583,
0.0586308129131794,
0.24647752940654755,
-0.02825184538960457,
-0.06248646229505539,
-0.7501344680786133,
-0.5735906362533569,
0.6412054300308228,
-0.16517342627048492,
0.039248447865247726,
-0.3521510362625122,
0.16957207024097443,
-0.09547469019889832,
0.025874633342027664,
0.12536711990833282,
-0.41621991991996765,
-0.13974498212337494,
-0.28421884775161743
] |
This article provides a status report on the global burden of cancer worldwide using the GLOBOCAN 2018 estimates of cancer incidence and mortality produced by the International Agency for Research on Cancer, with a focus on geographic variability across 20 world regions. There will be an estimated 18.1 million new cancer cases (17.0 million excluding nonmelanoma skin cancer) and 9.6 million cancer deaths (9.5 million excluding nonmelanoma skin cancer) in 2018. In both sexes combined, lung cancer is the most commonly diagnosed cancer (11.6% of the total cases) and the leading cause of cancer death (18.4% of the total cancer deaths), closely followed by female breast cancer (11.6%), prostate cancer (7.1%), and colorectal cancer (6.1%) for incidence and colorectal cancer (9.2%), stomach cancer (8.2%), and liver cancer (8.2%) for mortality. Lung cancer is the most frequent cancer and the leading cause of cancer death among males, followed by prostate and colorectal cancer (for incidence) and liver and stomach cancer (for mortality). Among females, breast cancer is the most commonly diagnosed cancer and the leading cause of cancer death, followed by colorectal and lung cancer (for incidence), and vice versa (for mortality); cervical cancer ranks fourth for both incidence and mortality. The most frequently diagnosed cancer and the leading cause of cancer death, however, substantially vary across countries and within each country depending on the degree of economic development and associated social and life style factors. It is noteworthy that high-quality cancer registry data, the basis for planning and implementing evidence-based cancer control programs, are not available in most low- and middle-income countries. The Global Initiative for Cancer Registry Development is an international partnership that supports better estimation, as well as the collection and use of local data, to prioritize and evaluate national cancer control efforts. CA: A Cancer Journal for Clinicians 2018;0:1-31. © 2018 American Cancer Society. | [
0.0013958429917693138,
0.012787441723048687,
-0.017560387030243874,
0.009349574334919453,
0.011356387287378311,
-0.032443828880786896,
0.0064879003912210464,
0.010672925040125847,
-0.008408090099692345,
-0.03572957217693329,
0.013452932238578796,
0.0083537045866251,
-0.0034630538430064917,
0.014634225517511368,
-0.01462166104465723,
0.0027303663082420826,
-0.04172194376587868,
-0.02352323941886425,
0.007878609001636505,
0.012513465248048306,
0.015126939862966537,
-0.024925721809267998,
0.00848391093313694,
0.012639554217457771,
-0.007426365278661251,
0.019970038905739784,
-0.02900765836238861,
0.0027782870456576347,
-0.007736011873930693,
0.009599670767784119,
-0.010962550528347492,
0.017052652314305305,
0.005995378363877535,
-0.008129941299557686,
0.02096695452928543,
-0.02162354439496994,
-0.0024706516414880753,
0.0061666821129620075,
0.0015318579971790314,
-0.0033426862210035324,
0.008298000320792198,
-0.01201571524143219,
-0.00561165576800704,
0.017541632056236267,
-0.011249272152781487,
0.0008710050024092197,
-0.013604223728179932,
0.016024809330701828,
0.006721400190144777,
0.012345081195235252,
-0.0061659482307732105,
-0.0016765967011451721,
-0.020319506525993347,
-0.020352857187390327,
-0.006278902292251587,
0.021525193005800247,
0.018251558765769005,
0.024791954085230827,
-0.017551792785525322,
-0.00854777917265892,
-0.003400680609047413,
-0.03372557833790779,
0.012348594143986702,
-0.007916002534329891,
-0.007942155934870243,
-0.06714671105146408,
-0.007330846972763538,
-0.01220165565609932,
-0.010126737877726555,
0.0018158543389290571,
0.013318927027285099,
0.00327110243961215,
0.02490299381315708,
-0.012067975476384163,
-0.0226607583463192,
-0.0046308608725667,
-0.00884236954152584,
0.005170821212232113,
0.01682024821639061,
-0.0022201682440936565,
-0.014714179560542107,
-0.0033837889786809683,
-0.024161500856280327,
0.02238238789141178,
-0.012439223006367683,
0.01602196879684925,
-0.013955050148069859,
-0.01839551329612732,
-0.011053110472857952,
0.012247507460415363,
-0.011380903422832489,
-0.007536012679338455,
-0.009225708432495594,
0.0048245820216834545,
-0.03378349542617798,
-0.030096683651208878,
-0.005969532765448093,
0.0060797203332185745,
0.00024662597570568323,
-0.017410192638635635,
0.012038491666316986,
0.0004365545464679599,
0.00007492754957638681,
-0.0009572778362780809,
-0.018714502453804016,
0.0044874995946884155,
-0.0006713843904435635,
-0.022840380668640137,
0.0015616882592439651,
-0.0030151172541081905,
-0.011449353769421577,
0.0024102451279759407,
0.01701381802558899,
0.022322259843349457,
0.02249438874423504,
-0.01020563580095768,
0.01650272123515606,
-0.0039033079519867897,
-0.011104822158813477,
0.042019449174404144,
0.0004749828949570656,
-0.000059091486036777496,
-0.009080073796212673,
0.014289862476289272,
-0.0041060494258999825,
0.04030503332614899,
-0.002629763912409544,
0.006191762164235115,
0.017442911863327026,
-0.002833032514899969,
-0.008829604834318161,
0.008623669855296612,
-0.024650350213050842,
-0.011900694109499454,
-0.011572817340493202,
0.0061543164774775505,
0.003201128914952278,
0.01189984381198883,
-0.014200638979673386,
0.006891390308737755,
-0.015269434079527855,
0.014714817516505718,
0.001887503545731306,
0.012774735689163208,
0.007241939194500446,
-0.0051048086024820805,
-0.008187900297343731,
0.02495904639363289,
-0.04270068183541298,
0.009339571930468082,
-0.021611753851175308,
0.008995472453534603,
0.0024191904813051224,
-0.011798153631389141,
0.02941703423857689,
0.017346469685435295,
0.003659662324935198,
-0.01959027722477913,
0.000685736071318388,
0.000631481409072876,
0.019632266834378242,
0.001584172248840332,
-0.01555672287940979,
0.007235061377286911,
0.03735643997788429,
-0.033806879073381424,
0.006888149306178093,
0.013590328395366669,
0.022016044706106186,
0.006339341402053833,
-0.0010183575795963407,
-0.00831529963761568,
-0.018620964139699936,
0.013578791171312332,
-0.005828714929521084,
-0.002901003696024418,
0.02223419025540352,
0.0050338818691670895,
0.013553980737924576,
0.06656906008720398,
-0.012091616168618202,
-0.006402101833373308,
0.008013545535504818,
0.0004274253733456135,
0.01737113855779171,
-0.0016530394786968827,
-0.007258322089910507,
-0.020377039909362793,
-0.018352443352341652,
0.012327533215284348,
0.006482450757175684,
-0.001582146855071187,
-0.009698673151433468,
0.004982013255357742,
0.028540726751089096,
0.0029124077409505844,
-0.01840488612651825,
-0.007618761155754328,
-0.00019078608602285385,
0.028385033831000328,
0.01302630640566349,
0.000982634723186493,
0.007356798276305199,
-0.02330099046230316,
-0.0125742107629776,
0.019122136756777763,
-0.014179756864905357,
-0.00902412086725235,
0.03814166411757469,
-0.0029210178181529045,
0.0020758984610438347,
0.007874347269535065,
-0.009686941280961037,
0.0021108665969222784,
0.008701257407665253,
-0.0012125466018915176,
-0.0027556573040783405,
0.036932315677404404,
-0.04762905091047287,
-0.010334264487028122,
-0.0006790975457988679,
0.01529022864997387,
0.010397827252745628,
0.03377062827348709,
-0.0018859126139432192,
-0.01944396272301674,
0.003732144134119153,
0.002847739728167653,
0.03451287001371384,
-0.011681558564305305,
0.00591306621208787,
-0.0018762811087071896,
-0.00821137335151434,
-0.014861702919006348,
0.022938651964068413,
0.014270546846091747,
0.009761258959770203,
-0.009623374789953232,
0.02000170573592186,
-0.004198178648948669,
-0.00030953576788306236,
-0.014858678914606571,
-0.013635422103106976,
0.004276578780263662,
-0.0015071071684360504,
-0.004973297007381916,
0.02938605099916458,
-0.01549107301980257,
-0.010575367137789726,
-0.026844073086977005,
0.008975837379693985,
0.02904861979186535,
0.026988931000232697,
0.0341886542737484,
0.023117758333683014,
-0.004205758683383465,
0.000045414548367261887,
-0.0016722098225727677,
0.023528527468442917,
0.002477753907442093,
0.015652915462851524,
0.013933125883340836,
-0.010361824184656143,
-0.02317684516310692,
0.004062029533088207,
-0.007677982561290264,
-0.006784013472497463,
-0.0008504579309374094,
0.01692103035748005,
-0.0010587656870484352,
0.014132704585790634,
-0.007743746042251587,
0.0034479054156690836,
-0.0817817971110344,
0.0005141751607879996,
0.0027954792603850365,
0.029352691024541855,
0.011379138566553593,
0.03733986243605614,
0.0024026986211538315,
0.014720505103468895,
-0.006284954026341438,
0.012722531333565712,
-0.010773283429443836,
0.013553811237215996,
0.004181492608040571,
-0.005890281870961189,
-0.0016199846286326647,
-0.012308270670473576,
0.004322672728449106,
-0.008222742937505245,
0.005107628181576729,
-0.00043712102342396975,
0.009644551202654839,
-0.010033445432782173,
0.019220398738980293,
-0.025476926937699318,
0.010821903124451637,
0.00505444873124361,
-0.007569496985524893,
0.0006538624875247478,
-0.016331665217876434,
0.00848477240651846,
0.01039827149361372,
-0.018035899847745895,
-0.017700063064694405,
-0.028436163440346718,
0.01589168980717659,
-0.010069210082292557,
-0.008221808820962906,
0.030833637341856956,
0.00526620214805007,
0.01451105996966362,
0.023419011384248734,
0.011196520179510117,
-0.011885475367307663,
-0.006187764927744865,
0.02126370742917061,
0.022001568228006363,
-0.03580240160226822,
0.002072717994451523,
0.012614553794264793,
-0.00991628598421812,
-0.021364860236644745,
0.013047885149717331,
0.01694527268409729,
0.0024596925359219313,
-0.0010517655173316598,
0.004789197817444801,
-0.010898374952375889,
-0.03385203331708908,
-0.012650612741708755,
-0.01406787522137165,
-0.011089588515460491,
0.014322670176625252,
-0.0067990184761583805,
0.01832800917327404,
-0.023819580674171448,
-0.021283812820911407,
0.014597270637750626,
-0.011076821014285088,
-0.008052391931414604,
-0.006493583787232637,
-0.001110347919166088,
0.0019676792435348034,
-0.0147299999371171,
-0.011734670028090477,
-0.005460008513182402,
-0.0029175886884331703,
-0.016347762197256088,
-0.009983235038816929,
-0.0010341856395825744,
0.012510601431131363,
-0.012458577752113342,
0.0019793896935880184,
-0.005568893160670996,
0.01835918240249157,
-0.021771902218461037,
0.0029197304975241423,
0.013279526494443417,
0.007278100587427616,
0.014865071512758732,
-0.014901993796229362,
0.02555536851286888,
0.012446384876966476,
-0.007265685126185417,
0.0025858180597424507,
0.007363838143646717,
-0.023507287725806236,
0.012448464520275593,
-0.017071571201086044,
0.005695285275578499,
0.006401100195944309,
0.017395535483956337,
-0.01980147510766983,
0.008559156209230423,
-0.01350643951445818,
-0.01802738383412361,
0.016362136229872704,
0.032470814883708954,
-0.01223193109035492,
-0.000037093646824359894,
-0.004228297621011734,
-0.011776113882660866,
0.00508192228153348,
-0.00027689471608027816,
0.02082333341240883,
0.011376312002539635,
-0.01893090456724167,
-0.0013229753822088242,
-0.013830103911459446,
0.07258567214012146,
0.00045180809684097767,
-0.0031166072003543377,
-0.02241174876689911,
0.011769450269639492,
-0.022887973114848137,
-0.029032515361905098,
0.005484085995703936,
-0.027432123199105263,
-0.010521365329623222,
0.011965680867433548,
-0.009507481008768082,
0.0519552156329155,
-0.011055568233132362,
-0.01083390973508358,
0.026807010173797607,
0.000539206201210618,
0.013000814244151115,
0.005751261953264475,
-0.011177542619407177,
-0.016964728012681007,
0.011570945382118225,
-0.02573705092072487,
0.0011171447113156319,
0.023477908223867416,
-0.010557730682194233,
-0.02055276744067669,
-0.009336370974779129,
0.0005092177307233214,
0.010145049542188644,
-0.007097874768078327,
-0.04214058816432953,
-0.0032123082783073187,
0.014292916283011436,
-0.008122237399220467,
0.004116070456802845,
-0.0054147737100720406,
-0.0010406728833913803,
0.005113495513796806,
-0.014480271376669407,
-0.016278961673378944,
-0.005847222171723843,
-0.010050157085061073,
0.0020746118389070034,
-0.047506485134363174,
0.0020070490427315235,
-0.008705812506377697,
-0.0050499411299824715,
-0.017968464642763138,
0.026037806645035744,
0.02211039327085018,
0.020849548280239105,
0.011562390252947807,
-0.0018319322261959314,
-0.00949196144938469,
-0.016237763687968254,
-0.017865873873233795,
-0.012394503690302372,
-0.010662258602678776,
-0.0018737297505140305,
0.005408373661339283,
0.006323136389255524,
-0.00785893201828003,
0.003472091630101204,
-0.019713688641786575,
-0.0019722941797226667,
-0.01837526634335518,
-0.0028191625606268644,
-0.0034604002721607685,
-0.01936045102775097,
-0.0036793765611946583,
0.046232372522354126,
0.0005050348117947578,
-0.017868679016828537,
-0.036172326654195786,
0.05088692158460617,
-0.019758865237236023,
0.018634725362062454,
-0.046533212065696716,
-0.0258011594414711,
0.014033395797014236,
-0.011003535240888596,
0.02003008872270584,
-0.010707499459385872,
0.0041660526767373085,
-0.004750687628984451,
-0.0018219815101474524,
-0.07479815930128098,
-0.028767835348844528,
0.004765953868627548,
-0.00845280010253191,
-0.00238859374076128,
0.02697986364364624,
-0.005574685987085104,
0.024442801252007484,
-0.01678341068327427,
-0.019296318292617798,
-0.014156237244606018,
-0.0017859104555100203,
0.007727662567049265,
-0.00017913617193698883,
0.01620250754058361,
-0.01709003560245037,
0.004398411139845848,
-0.009720945730805397,
-0.003276767209172249,
0.006561850197613239,
0.03162717446684837,
0.010298690758645535,
-0.002333228010684252,
0.000974701251834631,
-0.018311534076929092,
-0.08144277334213257,
0.03499620407819748,
-0.012746667489409447,
-0.011445071548223495,
-0.001663298811763525,
-0.021059632301330566,
0.030942261219024658,
-0.015911314636468887,
-0.026302261278033257,
-0.011587544344365597,
-0.01493383850902319,
-0.01831529475748539,
0.009887536987662315,
-0.004185138735920191,
-0.008020487613976002,
-0.0034625327680259943,
0.018277306109666824,
-0.015438813716173172,
-0.021488621830940247,
-0.009657786227762699,
0.003789979498833418,
0.02304926887154579,
-0.0002518979599699378,
-0.013996351510286331,
-0.01584172062575817,
0.015349239110946655,
0.0005031304899603128,
0.0002041312982328236,
0.018592676147818565,
0.012856822460889816,
0.024794315919280052,
-0.02290625125169754,
0.01632995717227459,
0.016880663111805916,
-0.004164505284279585,
-0.00961868092417717,
0.009541427716612816,
-0.0018859595293179154,
0.020591730251908302,
0.010719667188823223,
-0.006315276026725769,
0.0382661446928978,
0.002796273212879896,
-0.002172442153096199,
0.007125026546418667,
-0.012169202789664268,
0.013699427247047424,
-0.0052205780521035194,
0.014808663167059422,
0.010795911774039268,
0.0013127895072102547,
-0.016040652990341187,
-0.00015471293590962887,
0.018036779016256332,
-0.009384429082274437,
-0.006204538978636265,
-0.003980264067649841,
-0.005855941213667393,
0.024781066924333572,
0.03425479307770729,
0.008900268003344536,
-0.007586373947560787,
0.00841115415096283,
0.0716053694486618,
0.0032209702767431736,
0.021696146577596664,
0.014476933516561985,
-0.018607115373015404,
0.00012787780724465847,
0.004882562905550003,
0.013716490007936954,
-0.02578837424516678,
-0.0028531812131404877,
0.0014153700321912766,
0.0030174823477864265,
0.03461034223437309,
0.0077880192548036575,
0.029483217746019363,
-0.0034769615158438683,
0.009321708232164383,
0.01842091605067253,
-0.03649251163005829,
-0.024145500734448433,
0.0004922104999423027,
0.023934364318847656,
-0.0026370487175881863,
0.012873919680714607,
0.00233582966029644,
-0.02413734421133995,
-0.03111562877893448,
0.028453566133975983,
-0.007448513526469469,
-0.0016384776681661606,
-0.011774023994803429,
0.020023426041007042,
0.007885212078690529,
0.007883835583925247,
0.03136990964412689,
0.011106020770967007,
-0.0031924357172101736,
0.011449110694229603,
-0.022145599126815796,
0.0179473627358675,
0.01815778762102127,
-0.008329391479492188,
0.010676199570298195,
0.008426012471318245,
0.04311735928058624,
-0.019546017050743103,
0.003939572721719742,
0.01925721764564514,
-0.030379265546798706,
0.0089407404884696,
-0.01358336303383112,
0.016361746937036514,
0.002952615264803171,
-0.004238749388605356,
-0.020140334963798523,
-0.005498303100466728,
0.03511404991149902,
0.01620112732052803,
-0.007765611633658409,
0.004120827652513981,
0.017706770449876785,
-0.0040443893522024155,
-0.03013845905661583,
-0.0026499154046177864,
0.00983432400971651,
-0.022610951215028763,
0.021089915186166763,
-0.0172110628336668,
0.005434383172541857,
0.007949480786919594,
-0.0025289589539170265,
-0.018734939396381378,
0.011178286746144295,
-0.00048528797924518585,
-0.007870558649301529,
0.0025234525091946125,
-0.023180700838565826,
0.007476838305592537,
0.0030119996517896652,
0.011955386959016323,
-0.008596227504312992,
0.023437760770320892,
0.025847818702459335,
-0.02576950564980507,
-0.04334670677781105,
2.9802322387695312e-8,
0.036549799144268036,
-0.009852808900177479,
-0.009629769250750542,
-0.004750560037791729,
0.0042943330481648445,
0.004881591536104679,
-0.0012306312564760447,
-0.0042345523834228516,
0.005395815242081881,
0.035157859325408936,
0.005631533917039633,
0.003045090939849615,
0.030871331691741943,
-0.004034134093672037,
0.004384131636470556,
-0.012083889916539192,
-0.0063124848529696465,
-0.013432973995804787,
0.01027198601514101,
0.0020477157086133957,
-0.020660635083913803,
0.005941512994468212,
0.014951803721487522,
0.020509498193860054,
-0.015297595411539078,
-0.005650043021887541,
0.00272515881806612,
0.01904844306409359,
0.025203103199601173,
0.010148567147552967,
-0.005001687910407782,
0.023593202233314514,
-0.02377632074058056,
-0.01691753789782524,
-0.00022403430193662643,
-0.00021063396707177162,
-0.020976558327674866,
0.006611732766032219,
-0.014840120449662209,
0.0021752521861344576,
0.0003501370665617287,
-0.015690157189965248,
0.00008678622543811798,
0.015909351408481598,
0.017117485404014587,
-0.0014272814150899649,
0.009020177647471428,
0.027893373742699623,
-0.012088212184607983,
0.01069510169327259,
0.025510573759675026,
0.009805094450712204,
-0.012314644642174244,
-0.003961228299885988,
-0.0013220753753557801,
-0.0022774976678192616,
0.01121421530842781,
-0.01288282498717308,
0.007433428429067135,
0.003655634820461273,
0.015813853591680527,
0.011975536122918129,
0.009781155735254288,
-0.01919374242424965,
-0.00646355003118515,
0.007959773764014244,
0.008794649504125118,
0.0021311454474925995,
-0.00372822443023324,
-0.003895557951182127,
0.01950792595744133,
0.03662228584289551,
0.01592979021370411,
0.0037293494679033756,
-0.007662392687052488,
-0.0334397628903389,
-0.0003217090852558613,
-0.008066758513450623,
0.007135809399187565,
0.04529213532805443,
0.01163426786661148,
-0.010454465635120869,
0.011383403092622757,
0.015987709164619446,
0.028857529163360596,
0.0005804533138871193,
0.007248216308653355,
0.02747839130461216,
-0.033467333763837814,
0.0008106337627395988,
0.015087539330124855,
-0.004935814067721367,
-0.019202472642064095,
-0.005493941716849804,
0.02272365801036358,
-0.034197550266981125,
0.008804538287222385,
-0.009720977395772934,
0.0028520014602690935,
0.027673140168190002,
-0.00472872843965888,
-0.0070267291739583015,
0.001452284399420023,
-0.017938781529664993,
-0.0006344750872813165,
-0.028948184102773666,
-0.0011342715006321669,
0.0060585867613554,
-0.015399289317429066,
-0.0037266267463564873,
0.0036843984853476286,
-0.005355358123779297,
0.0026493975892663,
0.0017275989521294832,
0.004890919663012028,
-0.0000849645584821701
] | [
0.23929862678050995,
0.02997521497309208,
0.07327327877283096,
0.15322883427143097,
0.3652859926223755,
0.6642462015151978,
0.3456633687019348,
0.3053574860095978,
-0.5870455503463745,
-0.7200912237167358,
0.20014362037181854,
-0.09905513375997543,
-0.2783101499080658,
0.8137036561965942,
0.23558299243450165,
0.4554368555545807,
0.28576621413230896,
0.5939750075340271,
-0.08953101933002472,
-0.4273452162742615,
-0.5103989839553833,
-0.4049462676048279,
0.9242023825645447,
0.21409793198108673,
-0.31730371713638306,
-0.4855402708053589,
0.32345104217529297,
-0.07557603716850281,
-0.11666189879179001,
0.39806002378463745,
-0.011012180708348751,
0.4990466833114624,
0.6184911131858826,
-0.21888558566570282,
0.2959919273853302,
-0.061691559851169586,
-0.11052241176366806,
-0.08667735755443573,
0.16155178844928741,
-0.0521419532597065,
-0.30704963207244873,
-0.07115170359611511,
0.024539144709706306,
0.5555371046066284,
-0.14547191560268402,
-0.20947617292404175,
-0.7000505924224854,
0.934657096862793,
0.05658642575144768,
0.44396764039993286,
0.4348035752773285,
-0.11957240104675293,
-0.2188105434179306,
0.1789695918560028,
0.041494399309158325,
0.09398249536752701,
-0.24602295458316803,
0.5119349360466003,
-0.6770828366279602,
-0.22452950477600098,
0.3905496895313263,
-0.4275078773498535,
0.004572597332298756,
-0.09708352386951447,
0.48434147238731384,
0.09452864527702332,
0.23807601630687714,
0.22131294012069702,
-0.6770732998847961,
-0.6194348931312561,
0.2724471986293793,
-0.31739094853401184,
0.01727316528558731,
0.5721129179000854,
-0.2875843644142151,
0.08173955231904984,
-0.26184049248695374,
-0.2722766101360321,
0.368071585893631,
-0.15729209780693054,
-0.03871455043554306,
-0.2907770872116089,
0.35927093029022217,
0.04232146218419075,
0.16588012874126434,
-0.2086682766675949,
-0.0006251382292248309,
0.7043816447257996,
0.10774365812540054,
0.04055517166852951,
0.34140801429748535,
0.1488657295703888,
0.9627153873443604,
0.3500194251537323,
0.30262836813926697,
0.34675586223602295,
0.3130517303943634,
-0.14429771900177002,
-0.19962148368358612,
-0.8786601424217224,
-0.35149604082107544,
0.12937785685062408,
0.012080916203558445,
-0.37090450525283813,
-0.6035938858985901,
-0.32563433051109314,
0.20368880033493042,
-0.12685005366802216,
0.2456691712141037,
-0.16311514377593994,
-0.5319002866744995,
-0.16788329184055328,
-0.1351284384727478,
-0.4219872057437897,
-0.6232490539550781,
0.6688300967216492,
0.007159291300922632,
-1.2155150175094604,
0.5025854110717773,
-0.41871121525764465,
-0.18138755857944489,
0.3618300259113312,
-0.17050701379776,
-0.02938634529709816,
-0.1869334578514099,
0.281466007232666,
0.6751039028167725,
-0.13185864686965942,
0.00667355814948678,
0.34904181957244873,
0.132663294672966,
0.5790395736694336,
-0.26153281331062317,
-0.2764154374599457,
0.17986994981765747,
-0.4065665900707245,
-0.35143670439720154,
0.2182662934064865,
0.7211461067199707,
-0.3544904291629791,
-0.4058406949043274,
-0.8478527665138245,
-0.39699283242225647,
0.0766998678445816,
0.46768784523010254,
-0.13027720153331757,
-0.11098770052194595,
-0.5938540101051331,
-0.2591780424118042,
-0.8529130816459656,
-0.11474068462848663,
0.04336422681808472,
-0.32629188895225525,
-0.07514632493257523,
0.37732452154159546,
0.08295326679944992,
0.6378609538078308,
-0.643163800239563,
0.5007057785987854,
-0.31830206513404846,
0.6148878931999207,
-0.3052866458892822,
0.18745186924934387,
-0.20775024592876434,
0.00002299399238836486,
0.16628119349479675,
0.29674607515335083,
0.29580801725387573,
-0.25083184242248535,
0.2920369803905487,
-0.5377270579338074,
-0.15772296488285065,
0.1900326907634735,
-0.33216267824172974,
-0.014339589513838291,
-0.271244615316391,
0.4702516496181488,
0.5097617506980896,
0.2164774388074875,
0.07806428521871567,
-0.4674948751926422,
0.09189317375421524,
0.3136146068572998,
0.33397793769836426,
0.43640992045402527,
-0.5908489227294922,
0.43473824858665466,
0.3429776728153229,
0.44815245270729065,
0.4444211423397064,
-0.15686918795108795,
-0.8266131281852722,
0.6061528325080872,
0.11630944162607193,
0.8772593140602112,
-0.26300233602523804,
0.2723029851913452,
0.6689484715461731,
0.1142827719449997,
-0.45810219645500183,
-0.28290218114852905,
0.09238225221633911,
0.7595434188842773,
0.001343919662758708,
-1.169050931930542,
-0.07106030732393265,
-0.17827746272087097,
-0.3846549987792969,
-0.21183380484580994,
-0.35049235820770264,
0.5708894729614258,
-0.6564080715179443,
-0.28825652599334717,
-0.25389009714126587,
0.019958849996328354,
-0.18531693518161774,
-0.45931047201156616,
-0.07534131407737732,
-0.2558571398258209,
-0.22076596319675446,
0.5556548237800598,
-0.6163756251335144,
0.34654197096824646,
-0.17139852046966553,
0.5479142069816589,
0.6607179045677185,
-0.00773456459864974,
-0.12752291560173035,
0.4766639471054077,
-0.6495811939239502,
0.036343883723020554,
-0.08912437409162521,
0.23447301983833313,
0.035643450915813446,
-0.32803648710250854,
0.3311662971973419,
-0.17228469252586365,
-0.2765706181526184,
0.06937680393457413,
-0.18740013241767883,
0.13474516570568085,
0.27537214756011963,
-0.6400317549705505,
0.1419920027256012,
0.07798655331134796,
-0.20677518844604492,
-0.6322107911109924,
-0.5344864130020142,
-0.10879204422235489,
0.3173449635505676,
0.29065725207328796,
0.49537453055381775,
-0.2349490225315094,
-0.20759430527687073,
-0.04482422396540642,
0.11724822968244553,
0.31762173771858215,
-0.052367471158504486,
0.2616733908653259,
-0.4998509883880615,
-0.49616149067878723,
0.12843433022499084,
-0.0018246510298922658,
0.3413754999637604,
-0.14885330200195312,
-0.6219002604484558,
-1.1061489582061768,
-0.7222511172294617,
0.6084789633750916,
0.44633519649505615,
0.8112499713897705,
0.41633620858192444,
-0.633017361164093,
0.05587458610534668,
0.14142762124538422,
-0.5905467867851257,
0.14371445775032043,
0.7063236236572266,
-0.8018781542778015,
-0.38785597681999207,
-0.014727529138326645,
0.5231561064720154,
0.872272789478302,
-0.24616333842277527,
-0.2747562825679779,
0.16100406646728516,
0.42544108629226685,
-0.24267546832561493,
-0.06875739991664886,
0.006966396234929562,
-0.5802022218704224,
0.2897399961948395,
0.21782286465168,
0.115167535841465,
-0.19192317128181458,
-0.18761546909809113,
-0.019698498770594597,
0.23726266622543335,
0.33775410056114197,
-0.1908756047487259,
-0.5284827947616577,
-0.14376141130924225,
-0.12891064584255219,
-0.2883284091949463,
-0.26467660069465637,
0.005040133837610483,
-0.10730216652154922,
0.5305898189544678,
-5.864566802978516,
0.16482794284820557,
-0.30319854617118835,
-0.3733765184879303,
-0.33808478713035583,
0.23538325726985931,
0.2767839729785919,
-0.08047563582658768,
-0.0011772767174988985,
-0.23220500349998474,
0.2693493962287903,
0.7229921221733093,
0.6402239799499512,
0.22225645184516907,
-0.3426753580570221,
0.26941978931427,
-0.16685189306735992,
-0.27575889229774475,
0.10930971056222916,
-0.30227190256118774,
0.45399752259254456,
-0.15032735466957092,
-0.03498227894306183,
0.42198649048805237,
0.5366624593734741,
1.0122649669647217,
-0.5308433175086975,
-0.04471506550908089,
-0.37347981333732605,
-0.31307849287986755,
-0.005750164855271578,
-0.37663397192955017,
0.1753385365009308,
0.09057119488716125,
0.16778099536895752,
-0.24056728184223175,
-0.07172390073537827,
0.04842539504170418,
0.15252113342285156,
-0.2371959239244461,
-0.12339083850383759,
-0.2536381483078003,
-0.6116034984588623,
-0.578148365020752,
0.23486259579658508,
0.0001517806958872825,
-0.14429305493831635,
0.3088945150375366,
0.07119014859199524,
0.4766698479652405,
0.3336044251918793,
0.06264565885066986,
0.09632185101509094,
0.42742133140563965,
0.0421159565448761,
0.43092894554138184,
-0.42101460695266724,
0.4659288227558136,
-0.4473361670970917,
-0.03430541977286339,
-0.397684782743454,
0.06824016571044922,
0.34412333369255066,
-0.4434153735637665,
-0.11725979298353195,
0.12777072191238403,
-0.6646827459335327,
-0.5333314538002014,
0.41880708932876587,
-0.129640132188797,
-0.08853687345981598,
0.15963497757911682,
0.5615777373313904,
-0.5829443335533142,
-0.04756265878677368,
-0.7689744234085083,
-0.11118490248918533,
0.2338435798883438,
-0.27252674102783203,
-0.6965233683586121,
-0.4463578462600708,
-0.36143261194229126,
0.010780513286590576,
-0.22297129034996033,
0.048106368631124496,
-0.6193144917488098,
-0.4800209403038025,
-0.04266653209924698,
0.2789232134819031,
0.2995324730873108,
0.5714556574821472,
-0.6469998955726624,
0.6035317778587341,
0.17584818601608276,
0.5500037670135498,
0.8215532302856445,
0.41186922788619995,
0.3339966833591461,
0.510911762714386,
0.610406756401062,
0.6416376233100891,
-0.09432826191186905,
-0.8043532371520996,
-1.1096159219741821,
-0.3560100495815277,
-0.0313919335603714,
-0.20292668044567108,
0.34983208775520325,
0.6767144799232483,
-0.7330901622772217,
0.5645631551742554,
-0.14951369166374207,
-0.026955125853419304,
-0.7759281396865845,
0.6079402565956116,
-0.42681246995925903,
-0.47691720724105835,
0.18662886321544647,
0.6974499821662903,
-0.09035883098840714,
0.4275551438331604,
0.08807578682899475,
-0.3651248812675476,
0.3064141571521759,
0.6778445839881897,
0.12876318395137787,
0.23083658516407013,
0.3185313940048218,
-0.8498712182044983,
-0.008679873310029507,
0.027041932567954063,
0.6990655660629272,
-0.031223542988300323,
0.0067399125546216965,
0.01823361963033676,
0.004996417555958033,
-0.38203904032707214,
0.27289947867393494,
0.13987894356250763,
-0.15097969770431519,
0.17510779201984406,
0.2994123101234436,
-0.207319974899292,
0.042738646268844604,
-0.2804778814315796,
0.060540810227394104,
-0.2872190773487091,
0.02686278335750103,
0.2110142558813095,
0.19751906394958496,
0.3416418135166168,
0.14045478403568268,
0.12739159166812897,
-0.24474500119686127,
-0.6405577659606934,
0.19175761938095093,
0.5156459212303162,
0.3002678155899048,
-0.6795440912246704,
-0.5052447319030762,
-0.19055061042308807,
-0.1862155795097351,
-0.8762481212615967,
-0.11520631611347198,
-0.20283348858356476,
-0.25763997435569763,
0.1550939530134201,
-0.49542245268821716,
-0.18037238717079163,
0.5480301976203918,
-0.13559716939926147,
-0.24601222574710846,
0.06087749823927879,
0.3136320114135742,
0.15738089382648468,
0.08418729156255722,
-0.4069783687591553,
0.09628811478614807,
0.050856392830610275,
0.6057919263839722,
-0.1582706868648529,
-0.3190095126628876,
-0.47066012024879456,
0.8995769619941711,
0.2772446274757385,
0.9506470561027527,
-0.18783724308013916,
-0.19088318943977356,
-0.1954244077205658,
0.15295569598674774,
0.08208183199167252,
-0.2450365573167801,
-0.074810691177845,
-0.3690112233161926,
-0.1501811295747757,
-0.09881363809108734,
-0.0013656048104166985,
0.42178794741630554,
-0.0004972090828232467,
0.016549555584788322,
0.027339903637766838,
0.4652653634548187,
-0.6639754176139832,
0.07374926656484604,
0.40207579731941223,
-0.4469982087612152,
0.02351360209286213,
-0.09533660858869553,
-0.3735252320766449,
-0.05907853692770004,
-0.4959573447704315,
-0.19369132816791534,
0.2989160716533661,
0.46355748176574707,
-0.5954160094261169,
0.7191287279129028,
-0.1007629856467247,
-0.6437938809394836,
-0.14943815767765045,
0.2455659955739975,
0.15232110023498535,
0.19626958668231964,
0.016399195417761803,
-0.19856703281402588,
-0.26098376512527466,
0.4652804732322693,
0.08461324870586395,
-0.9193115234375,
-0.05267084389925003,
-0.5406038165092468,
-0.29542192816734314,
-0.1712123155593872,
-0.043981436640024185,
-0.11081071197986603,
0.3530925512313843,
-0.27202579379081726,
0.2090650051832199,
-0.03513311594724655,
0.03416292741894722,
0.07441330701112747,
0.15919004380702972,
0.26373380422592163,
-0.15933440625667572,
-0.6175211071968079,
-0.16956692934036255,
0.3020518124103546,
0.25566229224205017,
-0.9528487324714661,
-0.36629611253738403,
0.029220225289463997,
0.38164034485816956,
-0.9556032419204712,
-0.1517944633960724,
-0.3570479452610016,
0.7166719436645508,
0.19263209402561188,
0.06959643214941025,
-0.4967445135116577,
-0.3305741548538208,
0.1081407368183136,
-0.20195193588733673,
-0.40326088666915894,
0.057875629514455795,
0.2234172821044922,
0.4405010938644409,
0.029163450002670288,
-0.1883733868598938,
-0.06268316507339478,
-0.14130696654319763,
-0.30063366889953613,
0.3601868152618408,
0.731224536895752,
0.1206098347902298,
-0.09257645905017853,
-0.07222386449575424,
0.6082571744918823,
-0.21784944832324982,
0.04644066467881203,
-0.11022534966468811,
0.3371535539627075,
-0.5563548803329468,
-0.3434648811817169,
0.24445272982120514,
-0.11736167967319489,
0.0020298182498663664,
-0.349010705947876,
0.748513400554657,
0.0495900884270668,
0.006445775274187326,
-0.01167659554630518,
0.12481354176998138,
-0.4326770305633545,
-0.3901363015174866,
0.08098382502794266,
0.38044172525405884,
0.03119562938809395,
0.35624128580093384,
0.531014621257782,
0.19966945052146912,
-0.4416087865829468,
-0.608397364616394,
0.6438140869140625,
0.17979149520397186,
-0.32615208625793457,
0.42044609785079956,
0.12372319400310516,
0.4593207836151123,
0.010297277942299843,
-0.36164453625679016,
0.2383774220943451,
0.8410597443580627,
0.12336236238479614,
0.21199016273021698,
1.0343831777572632,
-0.39669355750083923,
-0.012224111706018448,
-0.646066427230835,
0.12933814525604248,
0.5535218715667725,
-0.1004839763045311,
-0.1307656168937683,
0.47928690910339355,
0.5272002816200256,
-0.04245022311806679,
0.031612321734428406,
0.008835588581860065,
-0.26042601466178894,
0.04478377103805542,
0.14698554575443268,
0.38690686225891113,
0.387101948261261,
0.5314772725105286,
-0.177603617310524,
0.8550187945365906,
0.06270544975996017,
-0.4896281659603119,
-0.3711095154285431,
-0.49433550238609314,
-0.380908340215683,
0.4409694969654083,
1.076373815536499,
0.017662953585386276,
-0.17422178387641907,
0.027905380353331566,
0.36609286069869995,
0.4854854345321655,
-0.4540136754512787,
-0.08776917308568954,
0.36976608633995056,
-0.1644972264766693,
0.30996081233024597,
-0.21120373904705048,
-0.7583179473876953,
0.1873762607574463,
-0.20302481949329376,
0.14263683557510376,
0.04085501283407211,
-0.37573930621147156,
0.00832951907068491,
0.26103487610816956,
-0.016165511682629585,
-0.02791888453066349,
-0.08933532983064651,
0.07363297045230865,
0.16413837671279907,
0.037312187254428864,
0.007774170022457838,
-0.17434464395046234,
-0.11831021308898926,
-0.2696436941623688,
0.20985844731330872,
0.11624044179916382,
-0.6007340550422668,
0.06308887153863907,
0.04094371944665909,
0.024892030283808708,
-0.18273337185382843,
0.030302848666906357,
-0.16341963410377502,
0.2847142219543457,
-0.6192094087600708,
0.07204117625951767,
0.044153157621622086,
-0.46369728446006775,
-0.14278537034988403,
-0.09927670657634735,
-0.4853067398071289,
-0.11212453246116638,
0.23988021910190582,
0.0385608933866024,
0.43847060203552246,
-0.3156024217605591,
0.1554623693227768,
0.3425144553184509,
0.09765027463436127,
-0.6589222550392151,
0.14393751323223114,
-0.04040642827749252,
0.008644393645226955,
0.5606594085693359,
0.01762310042977333,
-0.2637203633785248,
0.1181214451789856,
0.6119574308395386,
-0.748598575592041,
0.4168042540550232,
-0.36419209837913513,
-0.2560759484767914,
-0.2734147310256958,
0.22871485352516174,
0.4179122745990753,
0.11852530390024185,
-0.2798631191253662,
0.69273442029953,
-0.13243074715137482,
0.3353715240955353,
0.4434436559677124,
-0.5513963103294373,
-0.09119667112827301,
-0.4743383228778839,
-0.265563428401947,
-0.8145939707756042,
-0.04732270911335945,
-0.043085914105176926,
0.20660175383090973,
0.06078968197107315,
0.2011132836341858,
0.14071109890937805,
-0.044149238616228104,
0.9255021214485168,
-0.7182466983795166,
0.5376165509223938,
-0.7211158275604248,
-0.08317293226718903,
-0.8522034883499146,
0.30369067192077637,
0.4325847327709198,
-0.19194358587265015,
-0.38344883918762207,
-0.3955213129520416,
-0.03369781747460365,
-0.5603060126304626,
-0.11188028752803802,
0.0017971957568079233,
0.466734379529953,
0.022815411910414696,
0.099077507853508,
-0.05487712845206261,
-0.44066545367240906,
0.5907401442527771,
-0.24924390017986298,
0.14616437256336212,
0.7245610356330872,
-0.18233874440193176,
0.287691205739975,
0.12572245299816132,
0.055584441870450974,
-0.25130558013916016,
0.38524866104125977,
0.4553580582141876
] |
Environmental factors and host genetics interact to control the gut microbiota, which may have a role in the development of obesity and insulin resistance. TLR2-deficient mice, under germ-free conditions, are protected from diet-induced insulin resistance. It is possible that the presence of gut microbiota could reverse the phenotype of an animal, inducing insulin resistance in an animal genetically determined to have increased insulin sensitivity, such as the TLR2 KO mice. In the present study, we investigated the influence of gut microbiota on metabolic parameters, glucose tolerance, insulin sensitivity, and signaling of TLR2-deficient mice. We investigated the gut microbiota (by metagenomics), the metabolic characteristics, and insulin signaling in TLR2 knockout (KO) mice in a non-germ free facility. Results showed that the loss of TLR2 in conventionalized mice results in a phenotype reminiscent of metabolic syndrome, characterized by differences in the gut microbiota, with a 3-fold increase in Firmicutes and a slight increase in Bacteroidetes compared with controls. These changes in gut microbiota were accompanied by an increase in LPS absorption, subclinical inflammation, insulin resistance, glucose intolerance, and later, obesity. In addition, this sequence of events was reproduced in WT mice by microbiota transplantation and was also reversed by antibiotics. At the molecular level the mechanism was unique, with activation of TLR4 associated with ER stress and JNK activation, but no activation of the IKKβ-IκB-NFκB pathway. Our data also showed that in TLR2 KO mice there was a reduction in regulatory T cell in visceral fat, suggesting that this modulation may also contribute to the insulin resistance of these animals. Our results emphasize the role of microbiota in the complex network of molecular and cellular interactions that link genotype to phenotype and have potential implications for common human disorders involving obesity, diabetes, and even other immunological disorders. | [
0.0058396682143211365,
0.013541429303586483,
-0.016494445502758026,
0.01113588735461235,
0.022339902818202972,
-0.0009028923232108355,
0.011232731863856316,
0.0018372612539678812,
-0.009288603439927101,
-0.0244937464594841,
-0.01793702319264412,
0.0044243596494197845,
-0.02244480326771736,
0.01717674359679222,
-0.0006349575705826283,
-0.014668935909867287,
-0.015135953202843666,
-0.005136506166309118,
0.01286888588219881,
0.015342894941568375,
0.00939183309674263,
0.003708317643031478,
0.010423244908452034,
0.013925058767199516,
0.005754387471824884,
-0.02548845298588276,
-0.012431236915290356,
-0.014378364197909832,
-0.011517757549881935,
-0.019720494747161865,
0.0060643102042376995,
-0.0025722943246364594,
0.031939081847667694,
0.02514968439936638,
0.004534966312348843,
0.026451807469129562,
0.0010306882904842496,
0.025163136422634125,
0.005706293508410454,
-0.005099849309772253,
-0.006028503179550171,
-0.009205378592014313,
0.004063714295625687,
-0.02411019429564476,
-0.006787894759327173,
-0.006037003360688686,
0.0022640577517449856,
0.019996244460344315,
-0.005539853125810623,
0.007838670164346695,
0.002097400836646557,
-0.012507226318120956,
-0.013488253578543663,
0.04993043094873428,
-0.006707801483571529,
0.037214186042547226,
0.01754492148756981,
-0.016802698373794556,
0.003582045203074813,
0.04808370769023895,
0.0007171726319938898,
-0.0030950268264859915,
0.006205815821886063,
-0.024149544537067413,
0.040987346321344376,
-0.06674323230981827,
0.01796083152294159,
0.00016856379806995392,
0.009348100982606411,
0.0019414830021560192,
-0.01082957349717617,
0.006165565922856331,
0.0353575125336647,
-0.01916920207440853,
-0.017772596329450607,
-0.03035982884466648,
-0.007568977773189545,
0.011442858725786209,
0.03743699565529823,
0.02302687242627144,
0.012912747450172901,
-0.019872525706887245,
-0.0023525808937847614,
0.016682913526892662,
-0.01364933792501688,
0.015297342091798782,
-0.010040409862995148,
-0.012090443633496761,
-0.01657634973526001,
-0.0008774101734161377,
0.009099368005990982,
-0.03251594677567482,
0.008291305974125862,
-0.020292941480875015,
-0.016368500888347626,
0.030461899936199188,
0.001848895102739334,
-0.0068359533324837685,
0.0032175173982977867,
-0.0003089909441769123,
-0.0017132102511823177,
0.008328491821885109,
0.02442607656121254,
0.020382899791002274,
-0.021437430754303932,
0.01709577441215515,
0.03705703467130661,
0.028671059757471085,
-0.0040412042289972305,
0.018443822860717773,
-0.013041127473115921,
0.01094001717865467,
0.014888228848576546,
-0.006252132821828127,
0.003201776184141636,
0.014799659140408039,
-0.009583436883985996,
-0.012110024690628052,
0.009523794054985046,
-0.025806546211242676,
-0.016528993844985962,
0.018953567370772362,
-0.01828443445265293,
-0.018704622983932495,
0.002171874977648258,
-0.009596364572644234,
0.01007213443517685,
0.020702216774225235,
0.005085025914013386,
0.0019780993461608887,
-0.010135834105312824,
-0.0024078846909105778,
0.02594722807407379,
-0.009067695587873459,
-0.00968293845653534,
0.00467128399759531,
-0.030401363968849182,
0.013028368353843689,
0.0007617252413183451,
-0.022337540984153748,
-0.003292615059763193,
0.009805688634514809,
0.0030706203542649746,
0.00556878512725234,
0.010153837502002716,
0.0016127396374940872,
0.012644700706005096,
-0.016385499387979507,
0.04072663187980652,
-0.05314576253294945,
-0.0006120963953435421,
0.007319399155676365,
-0.012773117050528526,
-0.010914228856563568,
0.026270337402820587,
0.0028324206359684467,
-0.025333179160952568,
0.006692633032798767,
0.0001525669649709016,
0.012255243957042694,
0.008761442266404629,
-0.008336218073964119,
0.043931618332862854,
0.009260047227144241,
-0.0015833880752325058,
0.005287556909024715,
-0.02808811143040657,
-0.017133772373199463,
-0.013413133099675179,
0.00607839273288846,
-0.0032662677112966776,
-0.026361355558037758,
0.002877962775528431,
0.009574204683303833,
-0.014249194413423538,
0.003909611143171787,
-0.0005729524418711662,
0.009351357817649841,
-0.007621565833687782,
0.06621402502059937,
0.01919930800795555,
-0.010560967959463596,
0.018626075237989426,
-0.00257266778498888,
-0.016627667471766472,
-0.0020742733031511307,
0.019403815269470215,
-0.005054406821727753,
-0.017667753621935844,
0.0024438928812742233,
0.00326107838191092,
0.011856921017169952,
-0.007697724737226963,
0.0108674056828022,
-0.01298659760504961,
0.003119562054052949,
0.014369569718837738,
-0.008589512668550014,
0.0335877388715744,
0.006793905980885029,
0.015264216810464859,
-0.013526787981390953,
0.04389148950576782,
-0.020960716530680656,
-0.03352612629532814,
0.004413919057697058,
0.01679578423500061,
-0.03472638875246048,
0.0048262751661241055,
-0.0017435192130506039,
0.033831506967544556,
-0.0076598175801336765,
-0.01805729791522026,
-0.011867092922329903,
-0.011829794384539127,
0.022074315696954727,
-0.005455364938825369,
-0.013542521744966507,
0.012611121870577335,
-0.013586032204329967,
0.005285766441375017,
0.000732063315808773,
-0.02556414157152176,
-0.014444191008806229,
0.020704485476017,
-0.0038504889234900475,
-0.007299473974853754,
0.011268701404333115,
-0.038000356405973434,
0.017412250861525536,
0.00838431715965271,
-0.006267963908612728,
-0.013872472569346428,
0.004010980483144522,
-0.012274377048015594,
-0.036204926669597626,
0.015172244049608707,
-0.008651518262922764,
0.0210281815379858,
-0.009750000201165676,
0.0037312789354473352,
-0.013722602277994156,
0.01535370945930481,
-0.014205744490027428,
0.007958704605698586,
0.00746909249573946,
0.01564914546906948,
0.029617948457598686,
0.0021940600126981735,
-0.013918389566242695,
0.013105008751153946,
-0.01105340663343668,
0.003666734090074897,
-0.03704538568854332,
0.01630958542227745,
0.019088251516222954,
0.004260343499481678,
-0.012384958565235138,
0.02514200285077095,
-0.006859588902443647,
0.007842905819416046,
0.011905694380402565,
0.00044256378896534443,
0.014344200491905212,
-0.022930758073925972,
0.027585867792367935,
-0.005605511367321014,
0.021988559514284134,
0.02239469438791275,
0.01732281967997551,
0.0069514065980911255,
-0.006749406456947327,
-0.004627584479749203,
-0.08156144618988037,
-0.013096760958433151,
0.017531998455524445,
-0.03165055438876152,
0.00990317016839981,
0.007059051655232906,
0.006967553403228521,
0.009423645213246346,
-0.004779862239956856,
-0.017316369339823723,
0.003032123204320669,
-0.01712574064731598,
-0.0058660730719566345,
-0.0018142969347536564,
-0.00331393675878644,
-0.016375325620174408,
0.010951618663966656,
-0.01990177109837532,
-0.012574787251651287,
-0.0516008697450161,
-0.0026817694306373596,
-0.028328631073236465,
0.02237742953002453,
-0.006435852497816086,
0.02271955832839012,
-0.028243886306881905,
0.010399636812508106,
-0.0002712458372116089,
-0.004504018928855658,
0.0016357251442968845,
-0.018764322623610497,
-0.01566132716834545,
0.02271684631705284,
0.004047020338475704,
0.019715141505002975,
-0.01415603794157505,
-0.009607778862118721,
-0.016659772023558617,
-0.013693500310182571,
0.0482170432806015,
-0.015739750117063522,
0.0076600476168096066,
-0.002541087567806244,
-0.0006676921620965004,
0.015271971002221107,
0.0012277569621801376,
0.015744727104902267,
0.03294241428375244,
0.02209823578596115,
0.021448219195008278,
0.03139233589172363,
0.008994804695248604,
-0.0056421998888254166,
0.014931196346879005,
-0.016888432204723358,
0.002854245249181986,
-0.022002866491675377,
-0.001135528553277254,
-0.008072152733802795,
-0.009490146301686764,
0.0001309716608375311,
-0.0036413189955055714,
0.003077759174630046,
0.013843853026628494,
-0.0005577658303081989,
-0.015603561885654926,
0.018034491688013077,
-0.0009563621133565903,
-0.014016126282513142,
0.021082988008856773,
-0.01920679584145546,
0.0005143049638718367,
0.003753509372472763,
-0.005760316736996174,
-0.01783941127359867,
-0.0059762150049209595,
-0.01676720567047596,
-0.012584520503878593,
0.041946541517972946,
0.0013224114663898945,
-0.00427717762067914,
0.009352371096611023,
-0.022048525512218475,
-0.015114197507500648,
-0.008999023586511612,
-0.0006250273436307907,
0.004884885624051094,
0.035525426268577576,
0.022451870143413544,
-0.01597205363214016,
0.028404053300619125,
0.02409183606505394,
-0.009519915096461773,
0.013163452968001366,
0.002562069334089756,
-0.02235066518187523,
-0.017285214737057686,
0.007965208031237125,
0.010879438370466232,
0.009310534223914146,
-0.03569227457046509,
0.010639726184308529,
-0.02584436535835266,
-0.001307048136368394,
0.01243007555603981,
0.014146308414638042,
0.00673113577067852,
0.03311605751514435,
-0.014927873387932777,
-0.00004649694892577827,
0.003923468291759491,
-0.011268913745880127,
-0.0046493252739310265,
0.03299277648329735,
0.015423297882080078,
-0.0005177143029868603,
-0.007873833179473877,
-0.015868987888097763,
0.07186438143253326,
0.000974851893261075,
0.012763348408043385,
-0.031745344400405884,
0.0072599439881742,
-0.013008572161197662,
-0.012825108133256435,
0.0003296765498816967,
0.005736298393458128,
0.017873305827379227,
0.013556301593780518,
-0.016444489359855652,
0.005244145169854164,
0.007272606715559959,
-0.024559903889894485,
0.02610408514738083,
-0.0038635763339698315,
0.025922348722815514,
0.020571045577526093,
0.012325027957558632,
0.010405071079730988,
-0.034899815917015076,
-0.01627434603869915,
-0.0019502555951476097,
-0.0028589824214577675,
-0.029353847727179527,
0.0014640185981988907,
-0.014332568272948265,
-0.0393659882247448,
0.0025899061001837254,
0.0067168730311095715,
0.0005345633253455162,
-0.005380669608712196,
0.02616451308131218,
-0.013088495470583439,
0.01165933720767498,
0.07000856846570969,
-0.022783145308494568,
0.011604605242609978,
0.003140299813821912,
-0.004821785259991884,
-0.015884388238191605,
0.030854888260364532,
0.007045218255370855,
-0.004966370761394501,
-0.018118368461728096,
0.016854003071784973,
-0.0065297214314341545,
0.008940174244344234,
0.008976940996944904,
-0.0027319644577801228,
0.017174549400806427,
0.0077976747415959835,
0.009240612387657166,
-0.007283393293619156,
-0.013062834739685059,
0.032970331609249115,
-0.011972031556069851,
-0.0034524407237768173,
-0.022211842238903046,
0.02394871599972248,
-0.010797768831253052,
0.027660975232720375,
-0.02802976407110691,
0.024413131177425385,
-0.02666044421494007,
-0.03165234997868538,
0.004625178873538971,
0.01839633472263813,
-0.021942302584648132,
0.005981016904115677,
-0.01244605053216219,
0.0011864760890603065,
0.018836814910173416,
-0.03802631050348282,
0.031445328146219254,
-0.0027536284178495407,
0.02930488996207714,
0.009549537673592567,
0.023410968482494354,
-0.05640751123428345,
-0.01041020080447197,
0.020939819514751434,
-0.008697711862623692,
0.03236992284655571,
0.01825503632426262,
-0.001055778469890356,
-0.07463379204273224,
-0.018404405564069748,
-0.008567789569497108,
-0.01130131259560585,
0.024845276027917862,
0.016389740630984306,
-0.019541261717677116,
0.0165531225502491,
-0.01254575327038765,
-0.001097087049856782,
-0.007073382381349802,
-0.03455841541290283,
0.035637132823467255,
0.0011493386700749397,
0.013500930741429329,
0.01817443035542965,
-0.017277047038078308,
0.008489668369293213,
-0.012361515313386917,
-0.004932782147079706,
0.026249879971146584,
0.023107653483748436,
-0.04492085427045822,
0.017121827229857445,
0.015025204047560692,
-0.0808565765619278,
-0.002145948354154825,
0.008084738627076149,
0.002690505236387253,
-0.0058641089126467705,
-0.03257288783788681,
0.023421727120876312,
-0.005114704370498657,
-0.009420634247362614,
-0.019841235131025314,
0.0052353511564433575,
0.015140165574848652,
-0.02535472810268402,
-0.009607736021280289,
0.021568022668361664,
-0.013661415316164494,
0.010668681934475899,
0.027330439537763596,
0.022364595904946327,
0.010083302855491638,
-0.00020701810717582703,
0.016074592247605324,
-0.012916927225887775,
-0.018093446269631386,
-0.01160997711122036,
-0.0014535216614603996,
-0.01374792493879795,
0.014863977208733559,
-0.024257050827145576,
0.01431047823280096,
0.004195963032543659,
-0.008530105464160442,
-0.014833951368927956,
-0.02567482553422451,
-0.011240118183195591,
-0.029844336211681366,
-0.02361239865422249,
-0.020376082509756088,
-0.00652653444558382,
-0.005594923160970211,
-0.006162900943309069,
-0.0006735585629940033,
-0.03484427556395531,
0.025563426315784454,
0.0053344047628343105,
-0.02253340184688568,
0.008963638916611671,
-0.013219974935054779,
0.012579395435750484,
0.007655360735952854,
0.008111311122775078,
-0.010068750008940697,
0.005925463512539864,
0.015447334386408329,
-0.021495861932635307,
-0.007168155163526535,
-0.007936544716358185,
0.009801424108445644,
-0.016872789710760117,
0.014592496678233147,
0.007180106360465288,
-0.008277898654341698,
-0.002996272873133421,
0.07131946086883545,
0.008668916299939156,
0.004344097338616848,
-0.018002396449446678,
0.006928810849785805,
0.006367813795804977,
-0.017600376158952713,
0.0010477380128577352,
0.010832453146576881,
-0.02625896781682968,
-0.007292862515896559,
-0.02389412187039852,
0.013002967461943626,
0.013036917895078659,
0.004339694511145353,
-0.010347241535782814,
-0.009542951360344887,
-0.011081060394644737,
-0.01398414745926857,
0.027211841195821762,
0.011256882920861244,
-0.0063318656757473946,
-0.035488735884428024,
-0.005191650707274675,
0.02346533164381981,
0.004153028130531311,
-0.020284365862607956,
-0.006524582859128714,
-0.027381230145692825,
0.04426417872309685,
-0.004696790128946304,
0.0010919943451881409,
0.001440589432604611,
-0.017149576917290688,
0.013310929760336876,
-0.0038552647456526756,
-0.006531085819005966,
0.007482897490262985,
-0.014479003846645355,
-0.016303809359669685,
-0.009700538590550423,
-0.0019865327049046755,
-0.0037420657463371754,
0.00011255708523094654,
0.024243466556072235,
-0.01873338222503662,
-0.008637025952339172,
-0.010516531765460968,
0.013215086422860622,
0.01037682220339775,
0.02213991992175579,
-0.008854595012962818,
0.00925011932849884,
0.0147018413990736,
0.024030879139900208,
0.026123935356736183,
-0.035406697541475296,
0.01790907233953476,
-0.017083734273910522,
0.0007595517672598362,
-0.000241638976149261,
0.002086545107886195,
0.01491378340870142,
-0.026516089215874672,
0.0046023596078157425,
-0.013805580325424671,
0.01049080677330494,
-0.029701707884669304,
0.004050865303725004,
0.016939381137490273,
0.009992704726755619,
0.02899087779223919,
0.009099304676055908,
0.013012202456593513,
0.05796074867248535,
0.027640122920274734,
0.00763318594545126,
-0.009913962334394455,
0.013361142948269844,
0.003568223910406232,
-0.01594870164990425,
0.04630112648010254,
-0.016238410025835037,
-0.02189985290169716,
-0.004812679253518581,
0.002493276260793209,
0.00799267366528511,
-0.018080510199069977,
-0.0012125729117542505,
0.009696576744318008,
-0.006333744619041681,
0.0023160967975854874,
0.0065345196053385735,
0.020470822229981422,
0.006567140109837055,
0.03453580290079117,
0.021154293790459633,
0.005942165851593018,
-0.023463908582925797,
-0.005150884389877319,
-0.02248060330748558,
-0.01261249091476202,
0.0008568316698074341,
0.0010922704823315144,
-0.017098404467105865,
-0.0002995678223669529,
0.014400805346667767,
-0.006367329973727465,
0.013454662635922432,
0.000757792848162353,
0.026711763814091682,
-0.014272536151111126,
-0.00388149032369256,
0.01605050638318062,
0.011170577257871628,
0.0052896225824952126,
-0.0010037784231826663,
-0.028545882552862167,
-0.004541439935564995,
-0.010156691074371338,
0.008459066972136497,
0.005766044836491346,
-0.012357334606349468,
0.024282868951559067,
0.026802657172083855,
-0.012811398133635521,
-0.014927966520190239,
0.011271032504737377,
0.009600980207324028,
0.0018783006817102432,
0.034922756254673004,
-0.025092042982578278,
-0.023761466145515442,
-0.019151069223880768,
0.0018867612816393375,
0.04120863229036331,
0.002975478768348694,
-0.010547496378421783,
-0.008363932371139526,
0.015917113050818443,
-0.014718702994287014,
-0.010736426338553429,
-0.005737880244851112,
0.006686568725854158,
0.007280215620994568,
0.0018719960935413837,
0.02378646656870842,
0.012947791256010532,
0.00873093493282795,
0.004984642378985882,
0.01006045751273632,
0.014614466577768326,
-0.0003401313442736864,
-0.008211573585867882,
-0.006696618162095547,
0.02419101446866989,
0.020984595641493797,
-0.027513816952705383,
-0.005956370383501053,
-0.022470425814390182,
0.021714450791478157,
0.0033881564158946276,
0.018863754346966743,
0.008786329999566078,
-0.009738946333527565,
-0.01075939554721117,
0.006097296252846718,
-0.009758549742400646,
0.0019456560257822275,
-0.014203941449522972,
0.03640924021601677,
-0.01719488389790058,
-0.005028701387345791,
0.005098262801766396,
0.003069754457101226,
-0.007982918992638588,
-0.013998163864016533,
0.02055811509490013,
0.02346852794289589,
0.022682370617985725,
0.005587182007730007,
-0.01594727486371994,
0.005955607630312443,
-0.010918361134827137,
0.016832787543535233,
-0.0004997344221919775,
0.0006289653829298913,
-0.007192268036305904,
0.014957929030060768,
-0.006474874913692474,
0.005388258490711451,
-0.03557739406824112,
-0.004616124555468559,
0.007147065829485655,
0.00041752681136131287,
-0.015305239707231522,
0.002696655225008726,
-0.016666607931256294,
0.022358756512403488,
-0.007197127677500248,
-0.0005451070610433817,
0.0003184862434864044
] | [
0.32737794518470764,
0.36822059750556946,
-0.21456068754196167,
0.2599451541900635,
0.2660709619522095,
0.09368261694908142,
0.020206736400723457,
0.002118094591423869,
0.08909697085618973,
-0.787589967250824,
0.3777112364768982,
0.553447425365448,
-0.6354488730430603,
0.18322283029556274,
-0.16186048090457916,
0.7426183223724365,
-0.015255356207489967,
0.4387143552303314,
-0.04899211227893829,
-0.2236442267894745,
-0.35025203227996826,
-0.274731308221817,
0.45992496609687805,
0.11382914334535599,
0.07117073237895966,
-0.12277635931968689,
0.47552525997161865,
0.4117354154586792,
0.10771165043115616,
0.1815597116947174,
-0.06142903119325638,
1.185505747795105,
-0.3384491205215454,
0.18159031867980957,
-0.5651319622993469,
0.19232764840126038,
-0.41786354780197144,
0.010289113968610764,
0.1106349304318428,
0.20777365565299988,
-0.4230494201183319,
0.3956601321697235,
-0.4477350115776062,
0.8750631809234619,
0.08577346056699753,
-0.15889859199523926,
-1.4011179208755493,
0.689043402671814,
-0.1974020153284073,
0.1492525190114975,
0.16874249279499054,
0.23625510931015015,
0.08583194017410278,
0.2425539791584015,
0.3763534426689148,
0.5067957043647766,
-0.4896882474422455,
0.08670713752508163,
-0.11644871532917023,
-0.5482512712478638,
-0.1897299885749817,
0.18446069955825806,
-0.5730385780334473,
-0.03426778316497803,
-0.13734664022922516,
0.49820974469184875,
-0.28168588876724243,
-0.7584971189498901,
-0.2863941788673401,
0.037554942071437836,
-0.16780556738376617,
-0.17327986657619476,
-0.14848372340202332,
0.5568786263465881,
-0.24164430797100067,
-0.08980131894350052,
-0.022916480898857117,
-0.247986301779747,
-0.19062887132167816,
0.09435584396123886,
0.5657209157943726,
-0.42344042658805847,
0.33980631828308105,
0.10815862566232681,
0.5901430249214172,
-0.078069768846035,
0.16090713441371918,
0.7070071697235107,
-0.3228399157524109,
-0.04077912122011185,
0.23426374793052673,
0.015426438301801682,
0.5571849346160889,
0.4327859580516815,
0.37058526277542114,
0.3368072509765625,
0.8831459283828735,
-0.22902895510196686,
-0.1148110181093216,
0.02552034892141819,
-0.5435195565223694,
-0.40890464186668396,
-0.007831403985619545,
-0.10480087995529175,
-0.6266183853149414,
-0.5725017189979553,
-0.5595242977142334,
-0.6908032894134521,
-0.1816336065530777,
0.19156725704669952,
-0.636985719203949,
0.7569724917411804,
-0.31369447708129883,
-0.15408851206302643,
0.167570561170578,
0.08402879536151886,
0.07217488437891006,
-0.28287366032600403,
0.015129764564335346,
0.17625649273395538,
0.32411879301071167,
1.1398340463638306,
-0.3424585163593292,
0.3410130441188812,
-0.14414650201797485,
-0.03448054566979408,
-0.008798453956842422,
-0.4600245952606201,
0.24114303290843964,
-0.03253007307648659,
0.4359216094017029,
0.6676707863807678,
-0.026743728667497635,
-0.18154583871364594,
-0.031822096556425095,
0.25377729535102844,
0.48571276664733887,
0.1630135476589203,
0.40318816900253296,
-0.13085520267486572,
-0.4708152115345001,
-1.055458426475525,
0.015456100925803185,
-0.13087350130081177,
0.09749428927898407,
-0.34762364625930786,
-0.20828863978385925,
-0.09137290716171265,
0.1695288121700287,
-0.24643246829509735,
0.22507071495056152,
-0.19612433016300201,
-0.702049732208252,
0.04895830526947975,
0.09605754911899567,
0.5787056684494019,
0.2033596932888031,
-0.4314827024936676,
-0.05286229029297829,
0.33755722641944885,
0.3172912895679474,
-0.4215840697288513,
-0.2694433629512787,
-0.1982516199350357,
0.6911557912826538,
-0.05417735129594803,
0.17520473897457123,
0.6426825523376465,
-0.4307432174682617,
-0.20830494165420532,
-0.5397845506668091,
-0.37931159138679504,
0.18397502601146698,
-0.9245507121086121,
0.21235530078411102,
-0.24676766991615295,
0.3106013834476471,
0.06392517685890198,
0.6365132927894592,
0.4645026922225952,
-0.6153256297111511,
-0.10729844123125076,
-0.08189451694488525,
-0.2766631245613098,
0.5781827569007874,
-0.08769886940717697,
0.2820858061313629,
-0.27314990758895874,
0.2622796297073364,
0.005370496306568384,
-0.6882359385490417,
-0.37908825278282166,
0.6532195806503296,
-0.4617387056350708,
1.0535812377929688,
-0.49887922406196594,
-0.09270823746919632,
0.9087399840354919,
0.19469380378723145,
-0.005048212129622698,
-0.2253594845533371,
-0.34653326869010925,
0.336655855178833,
-0.5989459753036499,
-0.5341199636459351,
-0.1526394784450531,
0.025624006986618042,
-0.426825612783432,
0.2710675895214081,
0.26179584860801697,
0.2945851683616638,
0.04416251555085182,
-0.12019616365432739,
-0.048251938074827194,
0.3338928520679474,
-0.0892484188079834,
-0.7386387586593628,
0.06129392981529236,
-0.8869580030441284,
-0.09379919618368149,
0.16428469121456146,
-0.29604223370552063,
0.3757645785808563,
0.8188802599906921,
0.0514599047601223,
0.37653157114982605,
0.45089417695999146,
0.1303384155035019,
0.9505360722541809,
-0.7575410008430481,
0.5880432724952698,
-0.1100219339132309,
0.1213107481598854,
-0.4122631847858429,
-0.11363915354013443,
0.4437974989414215,
-0.16577023267745972,
0.026145823299884796,
-0.0349944569170475,
-0.13022364675998688,
-0.4420831799507141,
0.7227137684822083,
-1.0410404205322266,
0.4138030707836151,
-0.5418999195098877,
-0.45352500677108765,
-0.3717057704925537,
0.5796922445297241,
-1.5333906412124634,
-0.2868726849555969,
0.4964013993740082,
0.11075886338949203,
0.4585513770580292,
-0.35239946842193604,
-0.10483624041080475,
-0.34826982021331787,
-0.2878870964050293,
-0.1674354523420334,
0.2959962487220764,
-0.6472640633583069,
-0.13898029923439026,
0.14574864506721497,
0.20694832503795624,
-0.014624134637415409,
0.061515457928180695,
-0.3425472676753998,
-0.6582103371620178,
-0.4961495101451874,
0.39587488770484924,
0.7157200574874878,
1.1350046396255493,
-0.08028559386730194,
-0.7140326499938965,
0.1278880089521408,
0.15893135964870453,
-0.7256842851638794,
0.2819586992263794,
0.8368632197380066,
-0.47834640741348267,
-0.033577773720026016,
-0.38850831985473633,
0.46516722440719604,
0.6938439607620239,
-0.39151304960250854,
-0.5066267251968384,
-0.3573419749736786,
-0.0937381386756897,
-0.3226766586303711,
-0.543644905090332,
-0.05917726829648018,
-0.40456920862197876,
0.3238861858844757,
-0.4653506577014923,
-0.27659693360328674,
0.35299521684646606,
0.10334303975105286,
-0.20797567069530487,
0.6909619569778442,
0.5244117379188538,
-0.08390682935714722,
0.2231377810239792,
-0.06944754719734192,
0.11449947953224182,
0.07692839205265045,
-0.4315440058708191,
-0.10101403295993805,
-0.45530110597610474,
0.18511326611042023,
-5.664304256439209,
-0.1395973414182663,
0.3384988307952881,
0.06841124594211578,
-0.2363770604133606,
-0.3309823274612427,
1.4542332887649536,
0.15887099504470825,
0.136705681681633,
0.5198140144348145,
0.7514804005622864,
0.16868144273757935,
0.10132677853107452,
-0.1484823077917099,
-0.5332152247428894,
0.18564367294311523,
0.5201537013053894,
-0.20482288300991058,
0.25247615575790405,
0.40660184621810913,
0.07376968860626221,
0.11723414063453674,
-0.3260425925254822,
0.5933936238288879,
0.10727515816688538,
0.1618587076663971,
-0.8111253976821899,
0.07786738872528076,
0.15630623698234558,
-0.47566691040992737,
0.3172464966773987,
-0.4343711733818054,
0.15416312217712402,
-0.5117323398590088,
0.8033583760261536,
0.1175064817070961,
-0.6892026662826538,
0.17471365630626678,
-0.22636198997497559,
-0.08840081095695496,
0.21014563739299774,
0.2777179181575775,
-0.24258695542812347,
-0.20110103487968445,
0.23482847213745117,
-0.1295093148946762,
0.2374415546655655,
0.20587916672229767,
-0.24558508396148682,
0.6290050148963928,
0.20167377591133118,
-0.24729619920253754,
0.6112489700317383,
0.3163428008556366,
0.8248590230941772,
0.2219376266002655,
0.18830323219299316,
-0.141392782330513,
-0.01530111487954855,
-0.006739258766174316,
-0.3430896997451782,
-0.5040798187255859,
-0.27739301323890686,
-0.30270272493362427,
0.15393656492233276,
0.004149883519858122,
-0.5514070987701416,
-0.5462766289710999,
0.2592415511608124,
-0.4217076897621155,
-0.2760922610759735,
0.2940485179424286,
0.25439921021461487,
-0.6530442237854004,
-0.16106973588466644,
-0.38475388288497925,
0.09593623876571655,
0.11102697998285294,
0.2053091824054718,
-0.6283089518547058,
-0.566827654838562,
-0.020408594980835915,
-0.45597168803215027,
-0.0343058742582798,
0.1921098828315735,
-0.48270276188850403,
-0.37815314531326294,
-0.04210851714015007,
-0.715045690536499,
0.2244011014699936,
0.39778152108192444,
-0.3153681457042694,
0.20189347863197327,
0.5048169493675232,
0.3476957380771637,
0.21969038248062134,
0.5421050786972046,
0.14754661917686462,
0.15162384510040283,
0.11485864967107773,
0.614155113697052,
-0.3282216787338257,
-0.30432677268981934,
-0.7126966714859009,
-0.07660266011953354,
0.3077842891216278,
0.06973251700401306,
0.6226924657821655,
0.672110915184021,
-1.1909565925598145,
0.16380949318408966,
0.30142053961753845,
-0.2763690948486328,
-0.6476880311965942,
0.36211538314819336,
-0.2866275906562805,
-0.227812722325325,
0.46119359135627747,
0.9584841132164001,
-0.049594946205616,
0.07228337228298187,
0.5998679995536804,
-0.9189080595970154,
0.13013707101345062,
0.08372818678617477,
-0.39003726840019226,
0.05669184401631355,
0.44073301553726196,
-1.0589909553527832,
-0.24518419802188873,
0.025785228237509727,
0.32418379187583923,
-0.4189593493938446,
0.30850812792778015,
0.07740586996078491,
0.07233463227748871,
-0.04370745271444321,
0.25433704257011414,
0.1193387508392334,
-0.33156928420066833,
-0.13622774183750153,
-0.22809621691703796,
-0.04373170807957649,
-0.5083779692649841,
0.4307508170604706,
0.14873230457305908,
-0.25476759672164917,
0.1042693480849266,
-0.12166836857795715,
-0.24801087379455566,
0.03586415946483612,
0.2152247428894043,
-0.33508211374282837,
0.02582971379160881,
-0.39316144585609436,
0.09286145865917206,
0.4748246371746063,
0.28517773747444153,
0.6684847474098206,
-0.8836726546287537,
0.4389820098876953,
-0.29514187574386597,
-0.8724672198295593,
-0.07428726553916931,
-0.42292946577072144,
-0.09979808330535889,
0.1046445220708847,
-0.2875606417655945,
-0.20719122886657715,
0.4848698079586029,
-0.026889760047197342,
-0.25207459926605225,
-0.6510034799575806,
-0.5894700884819031,
-0.06627896428108215,
-0.9109799861907959,
-0.2961817681789398,
-0.12065640836954117,
-0.07139956951141357,
0.12885738909244537,
0.426140695810318,
-0.595723032951355,
-0.3023539185523987,
-0.026675201952457428,
0.26223012804985046,
0.11544942855834961,
0.42488911747932434,
0.2745315730571747,
-0.12654490768909454,
-0.5130721926689148,
0.09267184883356094,
0.0875181257724762,
0.2163890302181244,
-0.5337862372398376,
0.3369942009449005,
0.0473967008292675,
0.22982735931873322,
0.15665708482265472,
0.03725336864590645,
-0.25804638862609863,
0.08401226997375488,
0.6172628402709961,
-0.5482816696166992,
0.34257158637046814,
0.12250543385744095,
-0.12323609739542007,
-0.421467661857605,
-0.09124750643968582,
-0.42128634452819824,
-0.27078333497047424,
-0.36147961020469666,
-0.33438122272491455,
0.11151301860809326,
0.30311471223831177,
-0.402852326631546,
-0.35429245233535767,
0.3993580937385559,
0.13626356422901154,
-0.06984085589647293,
0.26563042402267456,
0.47885555028915405,
0.18046845495700836,
-0.4533398449420929,
-0.029211267828941345,
-0.270536869764328,
-0.07029291987419128,
0.64473956823349,
-0.32060375809669495,
0.129940465092659,
0.02326820231974125,
-0.1868562400341034,
-0.06570631265640259,
0.08424589782953262,
0.15732881426811218,
-0.1853710561990738,
-0.24591152369976044,
0.08185896277427673,
0.34069526195526123,
0.07467960566282272,
0.5570635199546814,
0.4914768636226654,
0.5086104273796082,
-0.41612061858177185,
-0.398790180683136,
0.09667450189590454,
0.8078606724739075,
-0.06343864649534225,
-0.1607712209224701,
-0.6647872924804688,
-0.44895946979522705,
0.6732766628265381,
-0.18427644670009613,
-0.13742271065711975,
0.8105543255805969,
0.49073970317840576,
-0.26384466886520386,
0.19478276371955872,
-0.2614305317401886,
-0.07040399312973022,
0.34171608090400696,
-0.04555988311767578,
0.31195634603500366,
-0.19219554960727692,
-0.015142953023314476,
0.464073121547699,
0.13175317645072937,
-0.26640191674232483,
-0.24062788486480713,
0.4553932845592499,
-0.25149956345558167,
0.36150893568992615,
0.016779426485300064,
0.6304882168769836,
0.46104204654693604,
0.14823271334171295,
0.08729920536279678,
-0.5385923981666565,
-0.1639414131641388,
0.0970173180103302,
-0.5368887782096863,
0.2117723822593689,
-0.6518505215644836,
0.3681113123893738,
-0.6963781118392944,
0.5381596684455872,
-0.9645327925682068,
0.09131104499101639,
-0.5654287338256836,
-0.1686602681875229,
-0.651186466217041,
-0.44682201743125916,
-0.2844958007335663,
-0.4540861248970032,
-0.618049681186676,
0.1301685869693756,
0.2899510860443115,
0.1707623451948166,
0.13353371620178223,
0.047024358063936234,
-0.2238127589225769,
-0.9014293551445007,
0.4987509846687317,
0.22772207856178284,
0.451598584651947,
0.5436273813247681,
0.38091275095939636,
0.12636001408100128,
0.02639647014439106,
-0.7173200845718384,
-0.062226276844739914,
0.11846727877855301,
-0.36347898840904236,
0.0755157470703125,
0.3863806426525116,
-0.06903564929962158,
0.5476289391517639,
-0.5395414233207703,
-0.3179629147052765,
0.6005200743675232,
0.24491102993488312,
0.255731463432312,
0.0764002799987793,
1.0426987409591675,
0.1668151617050171,
0.33476129174232483,
0.5131997466087341,
0.1645626425743103,
0.24232760071754456,
-0.20475539565086365,
0.6048580408096313,
0.27391278743743896,
0.9755187630653381,
-0.4077054560184479,
-0.03661232814192772,
0.035043586045503616,
0.48958703875541687,
0.3466227352619171,
-0.6176849603652954,
-0.5187554955482483,
0.10362377017736435,
0.6060935258865356,
0.24278375506401062,
-0.003497661557048559,
-0.2089749574661255,
0.21917736530303955,
0.09672686457633972,
-0.25613564252853394,
0.08575311303138733,
-0.08993789553642273,
0.060743823647499084,
-0.0040082382038235664,
-0.8876272439956665,
-0.629459023475647,
-0.08570891618728638,
-0.5245881676673889,
0.8231818079948425,
0.8097801804542542,
-0.5733833312988281,
-0.8167861104011536,
0.606869101524353,
-0.31782135367393494,
0.03583329916000366,
0.0797334536910057,
0.41138893365859985,
0.29297757148742676,
0.05138672888278961,
0.3362165093421936,
-0.2424861341714859,
0.6935688257217407,
-0.02230263687670231,
-0.40462765097618103,
-0.015485826879739761,
0.09074703603982925,
0.0650087371468544,
0.9356926083564758,
-0.24884535372257233,
0.2757212519645691,
-0.18826726078987122,
0.041577160358428955,
0.46166351437568665,
-0.29661086201667786,
0.06556332111358643,
-0.05715792998671532,
-0.5868405699729919,
-0.2247193306684494,
-0.30658549070358276,
-0.8611665368080139,
0.26507848501205444,
0.44082722067832947,
-0.10027876496315002,
0.21120475232601166,
-0.7456369400024414,
0.014961372129619122,
0.4788300395011902,
-0.2356494963169098,
-0.1669093817472458,
0.03933276608586311,
0.2343243807554245,
-0.027449503540992737,
-0.05825956538319588,
0.13538497686386108,
0.07042758911848068,
-0.5558124780654907,
0.6392789483070374,
-0.42189911007881165,
0.6980952024459839,
-0.5985650420188904,
-0.4353814423084259,
-0.31455889344215393,
0.37211427092552185,
0.9845097064971924,
-0.3165704905986786,
-0.18814533948898315,
0.31297606229782104,
0.2645535469055176,
0.31092652678489685,
0.2686593532562256,
-0.43894681334495544,
-0.3646699786186218,
-0.6591025590896606,
-0.00270884414203465,
-0.4009714722633362,
0.7250213027000427,
-0.053540706634521484,
-0.2212652564048767,
0.03236855939030647,
0.21769572794437408,
0.6495993137359619,
0.07236554473638535,
0.6349419355392456,
-0.6439242362976074,
0.5702532529830933,
-0.92298823595047,
0.11677911877632141,
-0.5057584047317505,
-0.07338859140872955,
0.04279950633645058,
0.2067687213420868,
0.2960091233253479,
-0.21875286102294922,
-0.07662610709667206,
-0.08277220278978348,
0.6878474354743958,
0.20981091260910034,
0.037344541400671005,
-0.2099398523569107,
-0.1537264883518219,
-0.2586309611797333,
-0.49695754051208496,
0.38601386547088623,
-0.04618697613477707,
-0.5494746565818787,
-0.06194973364472389,
0.5460458397865295,
-0.07005402445793152,
-0.1604621708393097,
0.19111166894435883,
-0.416730672121048,
-0.20255336165428162,
-0.12153682857751846
] |
Previous studies indicated that transforming growth factor (TGF)-β-mediated exosomal microRNAs (miRNAs) regulate the migration and invasion of lung cancer cells; however, whether and how TGF-β-mediated exosomal long noncoding (lnc) RNAs regulate migration and invasion of lung cancer cells remains unclear. Here, coculture experiments showed that TGF-β pretreatment increased the migration and invasion potential of lung cancer cells and TGF-β pretreated A549 cells increases vascular permeability. Furthermore, we found that TGF-β-mediated exosomes, as carriers of intercellular communication, regulated lung cancer invasion, and vascular permeability. Transcriptional analysis also revealed that lnc-MMP2-2 was highly enriched in TGF-β-mediated exosomes and might function by increasing the expression of matrix metalloproteinase (MMP)2 through its enhancer activity, with ectopic expression and silencing of lnc-MMP2-2 affecting lung cancer invasion and vascular permeability. Additionally, lnc-MMP2-2 and MMP2 expression was assessed semiquantitatively, and tissue-specific correlations between lnc-MMP2-2 and MMP2 expression were evaluated. These results suggested that exosomal lnc-MMP2-2 might regulate the migration and invasion of lung cancer cells into the vasculature by promoting MMP2 expression, suggesting this lncRNA as a novel therapeutic target and predictive marker of tumor metastasis in lung cancer. | [
-0.014012278988957405,
0.017256654798984528,
-0.0024238605983555317,
0.009886281564831734,
0.043050993233919144,
-0.02618478424847126,
0.014192983508110046,
0.010270149447023869,
-0.01704717054963112,
-0.042335107922554016,
-0.01227174699306488,
0.01381487213075161,
-0.004115970805287361,
0.020178761333227158,
-0.03722583130002022,
-0.0003954089479520917,
-0.024544326588511467,
0.01635967753827572,
0.017726756632328033,
0.010539704002439976,
0.0005967156030237675,
-0.02301659807562828,
0.011987850069999695,
0.021568138152360916,
0.03713507950305939,
0.010534700006246567,
-0.015962596982717514,
0.009129737503826618,
-0.014698493294417858,
0.00026901019737124443,
0.019315805286169052,
0.01885809376835823,
0.045113496482372284,
0.0005203054752200842,
-0.001672770595178008,
-0.01652573049068451,
-0.014964580535888672,
0.028891636058688164,
0.015381469391286373,
-0.0070085045881569386,
0.05973300337791443,
-0.01242830790579319,
-0.00031598599161952734,
-0.01041770912706852,
-0.007192135788500309,
-0.003923051059246063,
-0.005336377769708633,
-0.005315042100846767,
-0.03094532899558544,
0.009886807762086391,
0.004128030501306057,
-0.03524164855480194,
-0.016631145030260086,
0.00015080394223332405,
-0.007472974248230457,
-0.033899229019880295,
0.02062484808266163,
-0.011321861296892166,
-0.001965655479580164,
0.012167558073997498,
-0.008130468428134918,
-0.0330934002995491,
-0.011496201157569885,
-0.018432946875691414,
0.0016631430480629206,
-0.06628601998090744,
0.01779242232441902,
-0.005966152064502239,
-0.008539184927940369,
0.012322130613029003,
-0.012561141513288021,
0.012656616047024727,
0.01403849571943283,
-0.044031351804733276,
0.028862239792943,
-0.04456598311662674,
-0.014264075085520744,
-0.011172382161021233,
0.027296964079141617,
0.027153965085744858,
-0.004323158413171768,
-0.0230724960565567,
-0.02864108793437481,
0.025768067687749863,
-0.006492182612419128,
0.025731436908245087,
-0.005063258111476898,
-0.0340946689248085,
-0.0031406893394887447,
0.0074637639336287975,
0.010243970900774002,
0.003755440004169941,
-0.009457983076572418,
0.0003344921278767288,
-0.026084640994668007,
0.006323235109448433,
-0.011060593649744987,
-0.03711138665676117,
0.015620630234479904,
0.001500050537288189,
-0.01483625452965498,
0.02217133529484272,
0.02772916480898857,
-0.010427335277199745,
0.01269855722784996,
0.010150827467441559,
0.01689281314611435,
-0.00038760225288569927,
-0.0018911068327724934,
0.012496069073677063,
-0.035803865641355515,
0.007316946983337402,
0.008128758519887924,
0.005574081093072891,
0.014429514296352863,
0.004453765228390694,
-0.002498671878129244,
0.00014457758516073227,
0.011917862109839916,
-0.003968751057982445,
0.009536600671708584,
0.01585671678185463,
-0.01692722737789154,
0.008332519792020321,
0.005738444626331329,
-0.005057691130787134,
-0.019737064838409424,
0.01900070160627365,
-0.0323905386030674,
0.01115880161523819,
-0.013527072966098785,
0.018205054104328156,
-0.00701303081586957,
-0.04175013303756714,
-0.010450650006532669,
0.007121523842215538,
-0.0035680700093507767,
-0.01361671183258295,
-0.012185106053948402,
-0.004721770063042641,
0.0012544775381684303,
0.011086557060480118,
0.002092784270644188,
0.007672721054404974,
0.011453106068074703,
0.0056240190751850605,
-0.0007578313816338778,
-0.0007522290106862783,
-0.004613704048097134,
-0.03975098580121994,
0.01805424503982067,
0.007403695024549961,
0.009711997583508492,
-0.027745800092816353,
-0.0033119739964604378,
-0.03458525985479355,
-0.009443076327443123,
-0.04046802967786789,
-0.00867539457976818,
-0.020641319453716278,
-0.011638304218649864,
-0.022465486079454422,
0.03644183278083801,
0.01043775212019682,
0.0040175290778279305,
-0.014759743586182594,
-0.015160506591200829,
-0.0054678721353411674,
0.019781038165092468,
0.014047188684344292,
-0.010814491659402847,
-0.04211218282580376,
-0.015237050130963326,
0.012426155619323254,
-0.00423458032310009,
-0.0025321641005575657,
0.0090297507122159,
0.008546021766960621,
-0.015778549015522003,
0.06641800701618195,
-0.014670767821371555,
0.015239865519106388,
0.021512921899557114,
-0.037468284368515015,
0.008343496359884739,
-0.011752714402973652,
0.03317873179912567,
-0.0031981761567294598,
0.002211080165579915,
0.016587546095252037,
0.025775302201509476,
0.020248183980584145,
-0.028410978615283966,
-0.0016729100607335567,
-0.021618716418743134,
0.0028728428296744823,
0.02268901839852333,
0.0008959986735135317,
0.011694232001900673,
0.007291361223906279,
0.04662201553583145,
-0.01419975608587265,
0.02696961909532547,
-0.031514719128608704,
-0.007315360009670258,
0.006237167865037918,
0.004279051907360554,
-0.02907342091202736,
0.016231905668973923,
-0.006110960617661476,
0.01499821338802576,
-0.017550712451338768,
-0.007468667812645435,
-0.02026991732418537,
0.0048410892486572266,
0.009484449401497841,
-0.03547143191099167,
0.031549565494060516,
-0.016567401587963104,
-0.01405597198754549,
0.0006256185588426888,
0.021605636924505234,
-0.011772887781262398,
-0.008406123146414757,
0.02512742206454277,
-0.004120206926018,
0.0008876817300915718,
0.017477359622716904,
0.015747349709272385,
-0.017822621390223503,
0.015861818566918373,
-0.033440593630075455,
-0.017878174781799316,
-0.00712249893695116,
-0.0018270863220095634,
0.0298997201025486,
0.017327379435300827,
-0.027295732870697975,
0.024479873478412628,
-0.014492318034172058,
0.009438471868634224,
-0.011897988617420197,
0.025426557287573814,
-0.031482793390750885,
-0.011479307897388935,
0.0016849450767040253,
0.035926029086112976,
0.016320958733558655,
0.0032928637228906155,
-0.039638664573431015,
0.015175266191363335,
0.007284487597644329,
-0.024802519008517265,
-0.008792300708591938,
0.02497563511133194,
0.01702660508453846,
-0.005251103546470404,
0.007067899685353041,
0.025427184998989105,
-0.0032418861519545317,
0.006257487460970879,
0.01023897249251604,
-0.006453421898186207,
-0.024457590654492378,
-0.003752092830836773,
0.032544974237680435,
-0.0036280215717852116,
-0.012732256203889847,
-0.0094370162114501,
0.0033431253395974636,
0.01159791462123394,
-0.014245256781578064,
-0.003564780345186591,
-0.08077652752399445,
-0.014267560094594955,
0.006511843763291836,
-0.007749779615551233,
0.011634605005383492,
-0.02965548448264599,
-0.0024592652916908264,
-0.0027438346296548843,
-0.004430083092302084,
-0.02618623897433281,
-0.034088268876075745,
0.013105509802699089,
-0.013922793790698051,
0.013007882982492447,
-0.016139905899763107,
-0.021868564188480377,
0.02065742388367653,
-0.011920841410756111,
-0.013125576078891754,
-0.05756759271025658,
-0.029459673911333084,
-0.008471204899251461,
0.01580590195953846,
0.006166447885334492,
-0.027129054069519043,
0.02690785750746727,
0.013840319588780403,
-0.021122358739376068,
0.003845376428216696,
0.0005833114264532924,
-0.02471095696091652,
0.012748426757752895,
0.016859229654073715,
-0.00757517758756876,
0.023096801713109016,
0.019024726003408432,
0.008270341902971268,
-0.010256580077111721,
-0.0136948823928833,
0.01850944757461548,
-0.005728838965296745,
0.00952557846903801,
0.007505317218601704,
0.0046403296291828156,
-0.008246302604675293,
0.027458976954221725,
-0.010634204372763634,
-0.031412892043590546,
0.02869807928800583,
-0.013801395893096924,
0.0076170070096850395,
-0.0010854697320610285,
0.00955941528081894,
0.024512838572263718,
-0.012179223820567131,
-0.03063325025141239,
-0.04268212988972664,
0.006302987225353718,
-0.010380269959568977,
-0.021247630938887596,
0.023151665925979614,
-0.04436887055635452,
0.03256584331393242,
0.008684067055583,
0.016906248405575752,
-0.0009731436148285866,
0.015976116061210632,
0.010374965146183968,
-0.0209866464138031,
0.016738848760724068,
0.02722020633518696,
-0.01182100735604763,
-0.00647380668669939,
-0.01981285586953163,
-0.03774482384324074,
-0.013321978971362114,
-0.023245710879564285,
-0.0031625425908714533,
0.03223719447851181,
-0.029719138517975807,
-0.017709894105792046,
0.003715270897373557,
-0.011945406906306744,
0.022547932341694832,
-0.018105287104845047,
-0.0185125470161438,
0.009106128476560116,
0.06876444071531296,
0.018198760226368904,
-0.021165216341614723,
0.022167768329381943,
0.026860911399126053,
-0.008434351533651352,
0.012319087982177734,
-0.00010776659473776817,
-0.0179922953248024,
-0.008890362456440926,
0.001923315692692995,
0.025023479014635086,
0.012888525612652302,
-0.03872871398925781,
0.004722092300653458,
-0.016042910516262054,
-0.012185810133814812,
-0.013501636683940887,
0.017144368961453438,
-0.00003109755925834179,
-0.03508184850215912,
-0.02411523461341858,
0.0021334041375666857,
-0.037655118852853775,
0.0008072737837210298,
-0.010501770302653313,
0.04668442904949188,
0.010030856356024742,
0.029260464012622833,
-0.0037352743092924356,
-0.017118370160460472,
0.07107620686292648,
-0.008257064037024975,
0.00038993603084236383,
-0.008470254018902779,
-0.007869732566177845,
-0.02508227527141571,
-0.0006028774660080671,
0.022099215537309647,
-0.025321993976831436,
-0.04283112287521362,
0.013775570318102837,
-0.0122770294547081,
0.027047183364629745,
0.006117956712841988,
0.01131500955671072,
0.00705849239602685,
-0.020961884409189224,
-0.00242689810693264,
0.0446740947663784,
0.003357246518135071,
-0.011473305523395538,
-0.026495667174458504,
-0.02585488185286522,
-0.021188465878367424,
0.020737115293741226,
0.009061220102012157,
0.012522001750767231,
-0.015430375002324581,
-0.017734918743371964,
0.017269734293222427,
-0.002807189244776964,
-0.05587387830018997,
-0.010695494711399078,
0.0030799326486885548,
0.017744535580277443,
0.008667941205203533,
-0.009965503588318825,
-0.026290560141205788,
-0.001057047164067626,
-0.008166119456291199,
-0.0074879322201013565,
-0.015054848976433277,
0.02031812071800232,
0.001825660583563149,
-0.013766974210739136,
-0.0015515901613980532,
0.019948160275816917,
-0.01407634187489748,
-0.014074942097067833,
0.011657960712909698,
-0.0028931847773492336,
0.0023591548670083284,
0.009349368512630463,
0.005051428452134132,
-0.012346168980002403,
-0.03414685279130936,
0.007621536962687969,
-0.00007160374661907554,
-0.001653292216360569,
0.022695785388350487,
0.008202889934182167,
0.029398895800113678,
0.04281610623002052,
-0.02317807637155056,
0.000006050802767276764,
-0.03166870400309563,
0.013280969113111496,
0.003976417705416679,
0.024065079167485237,
-0.033146362751722336,
0.039654653519392014,
0.007379582151770592,
-0.04377393424510956,
0.0012561943149194121,
-0.022332504391670227,
0.021288704127073288,
-0.03457164764404297,
-0.045769788324832916,
0.016617752611637115,
0.02063790149986744,
-0.020840581506490707,
0.003935846965759993,
0.002880475949496031,
-0.016907669603824615,
0.02333701401948929,
-0.01736624911427498,
-0.010620455257594585,
-0.07352681457996368,
0.0012371418997645378,
-0.021019380539655685,
-0.014089638367295265,
-0.014804407022893429,
0.01457718200981617,
-0.026381632313132286,
-0.0032659280113875866,
-0.02231040596961975,
0.0007965528639033437,
-0.017365146428346634,
0.017187386751174927,
0.0005103177390992641,
-0.022115448489785194,
0.015841413289308548,
0.025040946900844574,
0.010233313776552677,
-0.01274130865931511,
-0.03213584050536156,
0.012286235578358173,
0.02301403507590294,
0.01950732246041298,
-0.018071332946419716,
-0.0002375618787482381,
-0.0054365163668990135,
-0.08001697063446045,
-0.01867138221859932,
0.02393951825797558,
0.00043195486068725586,
-0.004248008597642183,
-0.05599658936262131,
0.015370871871709824,
-0.01771504431962967,
0.014852285385131836,
-0.019777728244662285,
-0.021621212363243103,
0.0035337856970727444,
-0.03311891853809357,
-0.00572290038689971,
0.011077661998569965,
-0.013529527932405472,
0.010790071450173855,
-0.012757068499922752,
-0.018630271777510643,
-0.03898438811302185,
-0.005778762977570295,
-0.009023203514516354,
-0.009892621077597141,
-0.03315446898341179,
-0.01245986856520176,
-0.03366576135158539,
0.01022624596953392,
0.022332679480314255,
0.028932731598615646,
0.015908008441329002,
-0.012975526042282581,
0.007733133155852556,
0.001979354303330183,
-0.03655162453651428,
-0.04110392555594444,
-0.029194343835115433,
-0.00020213425159454346,
-0.002028890885412693,
-0.0009811525233089924,
-0.00643495749682188,
-0.005219150334596634,
0.026237137615680695,
-0.024753347039222717,
0.021033426746726036,
-0.01456882618367672,
-0.017314914613962173,
0.010876758024096489,
-0.018017619848251343,
0.0076898736879229546,
-0.024418901652097702,
0.009181860834360123,
-0.021021103486418724,
-0.009199303574860096,
0.029658198356628418,
-0.020501896739006042,
-0.010358484461903572,
-0.008933665230870247,
0.0012355827493593097,
0.008205498568713665,
0.014902956783771515,
0.0051138876006007195,
0.03835811838507652,
0.01653597131371498,
0.07143902778625488,
0.001293826848268509,
0.014897420071065426,
0.007534856908023357,
-0.007284514140337706,
0.009595937095582485,
-0.061066046357154846,
-0.018095429986715317,
-0.033936649560928345,
-0.02269752137362957,
0.033898670226335526,
-0.01457825768738985,
0.007700244430452585,
0.020434997975826263,
0.0023961542174220085,
0.023671472445130348,
0.01987937092781067,
0.005761465523391962,
-0.05552179366350174,
-0.006474773865193129,
0.0030474280938506126,
-0.0009528498630970716,
-0.014564601704478264,
-0.004191211424767971,
-0.014338929206132889,
-0.0075553907081484795,
-0.07389748096466064,
0.005304186604917049,
-0.0370866060256958,
0.018690451979637146,
-0.0092455530539155,
0.012194824405014515,
0.0003765632282011211,
0.026964183896780014,
0.02535344287753105,
0.01520588994026184,
-0.011174671351909637,
0.013028104789555073,
0.0007079425267875195,
0.002762823598459363,
0.01726367697119713,
-0.003997240215539932,
-0.0018910754006356,
0.0024498249404132366,
0.022036388516426086,
-0.04280689358711243,
-0.008421599864959717,
-0.002636245684698224,
-0.022851690649986267,
0.015186295844614506,
0.013523636385798454,
0.0007936540059745312,
0.004541974514722824,
0.014427609741687775,
0.023512933403253555,
-0.006689033471047878,
-0.0018548076041042805,
0.00269230455160141,
0.008973050862550735,
0.020997468382120132,
0.018035754561424255,
-0.014873097650706768,
0.00032904045656323433,
-0.0264006108045578,
0.02525952085852623,
0.009273629635572433,
0.017669349908828735,
-0.02311614155769348,
-0.03824175149202347,
0.02209884114563465,
0.00978478230535984,
0.0002071706112474203,
0.019811250269412994,
-0.01868264749646187,
0.03611576929688454,
0.003879312425851822,
0.010501965880393982,
0.0034763605799525976,
0.020560653880238533,
0.027436010539531708,
-0.013128417544066906,
-0.01635369099676609,
-0.009060714393854141,
0.0016643479466438293,
0.0017343172803521156,
0.0009465562179684639,
-0.0049330852925777435,
-0.008382514119148254,
-0.0026188422925770283,
0.01711815409362316,
0.03541810065507889,
-0.0034349225461483,
0.0037303552962839603,
0.0027210696134716272,
0.011288931593298912,
0.034625958651304245,
0.013387104496359825,
0.0006205246318131685,
0.005682470742613077,
0.03194624185562134,
0.003530838992446661,
-0.03143520653247833,
-0.0016126465052366257,
-0.001577827613800764,
-0.0329459011554718,
-0.009771907702088356,
0.0025347922928631306,
-0.006568641867488623,
0.008272171951830387,
0.01110437884926796,
0.013705198653042316,
-0.01660100743174553,
0.04624900966882706,
0.003083408810198307,
0.004388556350022554,
0.04686127230525017,
-0.010203288868069649,
0.02358904480934143,
0.006383310537785292,
-0.01986493170261383,
0.015968728810548782,
-0.006868123542517424,
-0.021405167877674103,
0.04717708379030228,
-0.0032996870577335358,
0.007948629558086395,
-0.01334239449352026,
0.027653178200125694,
0.031475987285375595,
-0.03556334599852562,
0.023581763729453087,
0.01807529851794243,
-0.02000189572572708,
0.024615172296762466,
0.0059637706726789474,
0.02920098789036274,
0.003860678058117628,
0.027861222624778748,
0.004281189758330584,
0.009145908057689667,
0.005899348761886358,
-0.02610430121421814,
0.007419872097671032,
-0.02006620168685913,
0.00797082856297493,
0.01028316468000412,
0.03324854001402855,
0.03900915011763573,
0.0007217732490971684,
-0.01708483323454857,
0.008861852809786797,
0.010206848382949829,
-0.00981447659432888,
-0.011073589324951172,
0.009032726287841797,
0.010642008855938911,
0.004586159251630306,
0.006054137833416462,
0.020823143422603607,
-0.020686857402324677,
-0.0016165440902113914,
-0.0030911709181964397,
-0.009877976030111313,
-0.011376663111150265,
0.03027009218931198,
0.048315249383449554,
-0.006358581595122814,
0.00418780418112874,
-0.011789253912866116,
-0.025364652276039124,
-0.00936951581388712,
-0.006668505724519491,
-0.01010107807815075,
0.0032557558733969927,
-0.03633745014667511,
-0.0004895524471066892,
-0.01602746732532978,
-0.01690831407904625,
-0.012222541496157646,
0.0064847348257899284,
-0.005780783481895924,
-0.048270925879478455,
0.01720616966485977,
-0.015986528247594833,
0.007920682430267334,
0.0031348196789622307,
0.0054128109477460384,
0.005404947325587273,
0.00687186187133193,
-0.016107842326164246,
-0.025734655559062958,
-0.007701734080910683,
-0.003942708484828472,
0.034590914845466614,
-0.013479642570018768,
0.031637609004974365,
0.012696183286607265,
0.03803464025259018,
-0.005777872633188963,
0.01579209417104721,
0.0006359360413625836,
-0.006794836837798357
] | [
0.0716002807021141,
-0.1187957376241684,
0.08395510911941528,
-0.03305325657129288,
0.42543745040893555,
-0.016282876953482628,
0.030334195122122765,
0.09946288168430328,
-0.5915921926498413,
-0.8549422025680542,
0.13291963934898376,
0.2360602617263794,
-0.5205011963844299,
0.2990306615829468,
0.05159759521484375,
0.6679895520210266,
0.13832126557826996,
0.360567182302475,
-0.06882984191179276,
-0.83732670545578,
-0.21976017951965332,
-0.1274430751800537,
0.8608309030532837,
0.040750857442617416,
0.3540511131286621,
-0.440995991230011,
0.3482295274734497,
-0.073941171169281,
0.45148026943206787,
-0.2141008824110031,
-0.3493649959564209,
0.7362675070762634,
0.11942071467638016,
0.09537507593631744,
-0.13905228674411774,
-0.33375412225723267,
-0.31137147545814514,
-0.14265452325344086,
-0.12689410150051117,
0.20996282994747162,
-0.38190290331840515,
-0.049467746168375015,
-0.24512271583080292,
0.6147761344909668,
0.17432236671447754,
-0.6497947573661804,
-1.4929884672164917,
0.8742347955703735,
0.32828453183174133,
-0.0963595062494278,
0.20395873486995697,
0.0686461552977562,
0.4453171491622925,
0.2486843317747116,
0.29211726784706116,
0.36319732666015625,
-0.3374345004558563,
-0.007855256088078022,
0.48306336998939514,
-0.5217775106430054,
0.13871930539608002,
-0.08478445559740067,
-0.5632326006889343,
0.12774668633937836,
0.15872332453727722,
0.4767856001853943,
0.34963542222976685,
-0.7353724837303162,
-0.28701379895210266,
-0.6599727272987366,
0.052437372505664825,
-0.25837230682373047,
-0.15740476548671722,
0.4174072742462158,
-0.05491619184613228,
-0.02596731297671795,
-0.1941107213497162,
-0.32157936692237854,
0.016868622973561287,
-0.15481744706630707,
0.10478650778532028,
-0.1477426290512085,
0.022255918011069298,
0.10275720059871674,
0.3714647889137268,
0.039417628198862076,
-0.6189697980880737,
0.5910571217536926,
-0.5711546540260315,
-0.2890019118785858,
-0.04229268059134483,
-0.2714369297027588,
0.35916170477867126,
0.46120697259902954,
0.45086994767189026,
0.4553276598453522,
-0.15187795460224152,
0.032112542539834976,
-0.0354301743209362,
0.06737767159938812,
-0.5806002020835876,
0.16756939888000488,
0.2519550323486328,
-0.44590556621551514,
-0.3835064470767975,
-0.42501986026763916,
-0.13620708882808685,
-0.6413404941558838,
-0.17572259902954102,
0.11480143666267395,
-0.4493144750595093,
-0.06633296608924866,
-0.2680228054523468,
-0.40648388862609863,
0.30024421215057373,
0.2934495508670807,
0.44635871052742004,
-0.8133092522621155,
0.20147758722305298,
0.292399525642395,
-0.0146709019318223,
1.6655445098876953,
-0.3930974006652832,
0.38415777683258057,
-0.2619561553001404,
-0.17944103479385376,
0.5576895475387573,
-0.23804530501365662,
-0.44331252574920654,
0.5582480430603027,
0.16735419631004333,
1.0465350151062012,
-0.6807679533958435,
0.3096833825111389,
-0.09069129079580307,
-0.08885519206523895,
0.27538004517555237,
0.2224922925233841,
0.5112433433532715,
-0.1898874193429947,
-0.5082940459251404,
-0.6549654603004456,
-0.25783011317253113,
0.02370593696832657,
-0.17113074660301208,
-0.4377882480621338,
-0.20715713500976562,
-0.4551492929458618,
-0.0684436559677124,
-0.39964795112609863,
-0.010280711576342583,
-0.2721753418445587,
-0.865035891532898,
0.0808112770318985,
0.08908815681934357,
0.3173168897628784,
0.021128997206687927,
-0.24374113976955414,
0.08624419569969177,
0.38945433497428894,
0.20989331603050232,
-0.2531672716140747,
-0.24802722036838531,
-0.005346245132386684,
0.4053305387496948,
0.0036239654291421175,
0.26481667160987854,
0.6261962056159973,
-0.19530656933784485,
-0.37935593724250793,
-0.4108600318431854,
-0.3546251058578491,
-0.06290876865386963,
-0.6850789785385132,
-0.017819911241531372,
0.06454156339168549,
0.5169150233268738,
-0.127774178981781,
-0.041680723428726196,
0.2932347357273102,
-0.7129420042037964,
-0.09765435755252838,
-0.31302887201309204,
-0.4758613705635071,
0.5916596055030823,
0.38137248158454895,
0.43057018518447876,
0.25763067603111267,
0.338335245847702,
-0.03550463914871216,
-0.06875389814376831,
-0.22542428970336914,
0.7635902762413025,
-0.5815095901489258,
1.2000335454940796,
-0.1855001300573349,
0.4341495633125305,
1.3479855060577393,
0.25869524478912354,
-0.27074962854385376,
-0.6478564739227295,
0.2589060366153717,
0.8203274607658386,
-0.36201736330986023,
-0.31364673376083374,
-0.11712770164012909,
0.029788022860884666,
-0.38964685797691345,
0.07245854288339615,
0.024519072845578194,
0.42277491092681885,
-0.17532086372375488,
0.19521278142929077,
-0.36413583159446716,
0.30081987380981445,
-0.3589497208595276,
-0.23005078732967377,
0.11658426374197006,
-0.8730956315994263,
0.22203576564788818,
0.3166673481464386,
-0.5847013592720032,
0.5660309791564941,
1.001710057258606,
0.092982217669487,
0.8046874403953552,
0.34082722663879395,
0.20972967147827148,
0.5403450727462769,
-0.016843091696500778,
0.274249792098999,
-0.5856077075004578,
0.0703984871506691,
-0.28280478715896606,
-0.20455807447433472,
0.4205089509487152,
0.30245938897132874,
0.08501295745372772,
-0.28057995438575745,
0.20136959850788116,
-0.1807980239391327,
0.6105214357376099,
-0.7256428003311157,
0.13348887860774994,
-0.2822931110858917,
-0.3636716306209564,
-0.4032117426395416,
-0.10067499428987503,
-0.7089971303939819,
-0.1863170713186264,
0.3687581419944763,
0.2143528312444687,
0.40113237500190735,
-0.4979178011417389,
-0.06078144535422325,
0.34410715103149414,
-0.026423601433634758,
-0.24060983955860138,
0.5056750178337097,
-0.68968665599823,
0.024561434984207153,
-0.15814632177352905,
0.32872867584228516,
0.3186368942260742,
-0.10573668777942657,
-0.23611298203468323,
-0.8627327680587769,
-0.265511691570282,
1.0813369750976562,
0.6211948990821838,
0.9150351881980896,
0.205499529838562,
-0.7096943855285645,
0.04978877678513527,
0.18930548429489136,
-0.41888532042503357,
0.210670605301857,
0.811228334903717,
-0.47463902831077576,
-0.378119558095932,
-0.2721286416053772,
0.3445427715778351,
0.949607789516449,
-0.23472069203853607,
-0.5011778473854065,
0.3459119200706482,
-0.1982663869857788,
0.1337909996509552,
-0.2856212258338928,
-0.24928750097751617,
-0.16535553336143494,
0.2223120629787445,
-0.2493944764137268,
0.2716924846172333,
0.2002546340227127,
0.370429664850235,
-0.17942620813846588,
0.26107704639434814,
0.6540575623512268,
0.010592111386358738,
-0.035148829221725464,
0.17819394171237946,
-0.26897361874580383,
-0.21452699601650238,
-0.12897199392318726,
0.017412979155778885,
-0.6393390893936157,
0.24684616923332214,
-5.814196586608887,
0.15806324779987335,
-0.017736777663230896,
-0.16142690181732178,
-0.33442074060440063,
-0.2596496045589447,
0.9442565441131592,
-0.04404157027602196,
0.2929135262966156,
0.17945775389671326,
0.2773370146751404,
0.23984785377979279,
-0.32920143008232117,
-0.15809854865074158,
-0.47893744707107544,
0.1627332717180252,
0.15043948590755463,
-0.2773834764957428,
0.8781329989433289,
-0.13371901214122772,
0.33426231145858765,
-0.3166256248950958,
-0.22819015383720398,
0.4471670389175415,
0.2196376770734787,
-0.20102529227733612,
-0.8002557754516602,
-0.25312143564224243,
-0.30637386441230774,
-0.3926399350166321,
0.05407778546214104,
-0.3179926574230194,
-0.08536714315414429,
0.11609244346618652,
0.5874432921409607,
-0.2274876981973648,
-0.22012287378311157,
-0.22618268430233002,
0.3414420485496521,
-0.22483183443546295,
0.6465801000595093,
0.5713722705841064,
-0.39506688714027405,
0.026079390197992325,
0.07293429225683212,
-0.32824671268463135,
-0.11845927685499191,
0.43141472339630127,
-0.273257851600647,
0.8764342069625854,
0.09289625287055969,
-0.3486661911010742,
0.46156045794487,
0.48636290431022644,
0.4757625162601471,
-0.0005350358551368117,
-0.27544891834259033,
-0.12348965555429459,
-0.5832800269126892,
0.13414393365383148,
-0.11105335503816605,
-0.04901294782757759,
-0.1228460967540741,
-0.7886497378349304,
-0.1284465193748474,
0.20064520835876465,
-0.9578848481178284,
-0.7350443601608276,
0.3504788875579834,
-0.2471005916595459,
-0.19426825642585754,
0.29137811064720154,
0.42709556221961975,
-0.49873849749565125,
0.41338059306144714,
-0.17815271019935608,
0.014910385943949223,
0.25667494535446167,
-0.11725763231515884,
-0.16802632808685303,
-0.28561514616012573,
-0.14539411664009094,
-0.05547993630170822,
-0.44914335012435913,
0.0772939994931221,
-0.5915157198905945,
-0.372745156288147,
-0.1661570817232132,
-0.7297784090042114,
0.3667457401752472,
0.4744608998298645,
-0.6153516173362732,
0.25223055481910706,
0.644368588924408,
0.3249184191226959,
0.20751860737800598,
0.11878511309623718,
0.24035200476646423,
0.5247433185577393,
0.289936363697052,
1.0854891538619995,
0.04405095428228378,
-0.5773144960403442,
-0.6639872789382935,
-0.017193568870425224,
0.5067043900489807,
-0.2148333340883255,
0.2307370901107788,
0.7675727009773254,
-0.6765082478523254,
0.3203381299972534,
-0.053677335381507874,
-0.2835095524787903,
-0.28602418303489685,
0.38473474979400635,
-0.40229901671409607,
-0.19168324768543243,
-0.07484395802021027,
0.822237491607666,
-0.15553365647792816,
0.4089392125606537,
0.3282068967819214,
-0.839486300945282,
0.48149600625038147,
0.5077083110809326,
-0.022809602320194244,
-0.0023375223390758038,
0.7767406105995178,
-0.8968698978424072,
-0.24360254406929016,
0.4972541928291321,
0.3554917275905609,
-0.28140947222709656,
-0.4989868700504303,
0.24604488909244537,
-0.4222317934036255,
-0.5565599203109741,
0.34808844327926636,
0.15862780809402466,
0.03260188177227974,
-0.03265232592821121,
-0.33104732632637024,
0.15258879959583282,
-0.0012349981116130948,
0.28729209303855896,
0.21673931181430817,
0.09432538598775864,
0.004506605677306652,
-0.48940008878707886,
-0.20846915245056152,
-0.0065868087112903595,
-0.2099442481994629,
0.15449722111225128,
0.07718884199857712,
-0.03222834691405296,
0.2616429328918457,
0.6071061491966248,
0.0863291546702385,
0.32230862975120544,
-0.6184129118919373,
0.4513759911060333,
0.32920119166374207,
-0.4331917464733124,
0.33119988441467285,
-0.5579911470413208,
-0.19362352788448334,
-0.08145973086357117,
-0.3602554500102997,
-0.15180565416812897,
0.5526303052902222,
-0.4653226435184479,
-0.07639062404632568,
-0.4404771029949188,
-0.0884862169623375,
0.03905220702290535,
-0.42214664816856384,
-0.07767701148986816,
0.296335905790329,
0.005419790744781494,
0.06026826798915863,
0.06455574929714203,
-0.4438190460205078,
-0.5263615846633911,
0.3278343677520752,
0.19923020899295807,
0.15702730417251587,
-0.011816373094916344,
-0.02826537936925888,
-0.19862361252307892,
-0.481761634349823,
-0.10581019520759583,
0.19381603598594666,
-0.09017399698495865,
-0.6482453942298889,
0.32599371671676636,
-0.2858259975910187,
0.12235945463180542,
0.2748081088066101,
-0.07926756888628006,
-0.6325921416282654,
0.30920740962028503,
0.412213534116745,
-0.5690457224845886,
0.41303306818008423,
0.14583300054073334,
0.24117770791053772,
-0.34217530488967896,
-0.08278847485780716,
0.19681131839752197,
-0.12834562361240387,
-0.4128964841365814,
-0.6692785620689392,
0.36890825629234314,
0.24920570850372314,
-0.07502007484436035,
0.1750328689813614,
0.34184759855270386,
0.09285829216241837,
-0.41434672474861145,
0.27479106187820435,
0.3159675896167755,
-0.14759084582328796,
-0.21489626169204712,
-0.3491748571395874,
-0.7279456257820129,
0.1922714114189148,
0.29862916469573975,
-0.6837403774261475,
0.22580550611019135,
-0.027627181261777878,
0.1709708273410797,
-0.4380667507648468,
0.029846705496311188,
-0.005531357601284981,
-0.268573135137558,
-0.37220877408981323,
-0.37878966331481934,
0.21191351115703583,
-0.01817193627357483,
0.625660240650177,
0.3601667582988739,
0.4962587356567383,
-0.562041699886322,
-0.18142513930797577,
-0.3807913661003113,
0.6401755213737488,
0.14139598608016968,
-0.5036461353302002,
-0.47333335876464844,
-0.22404730319976807,
0.3829113245010376,
-0.3443654477596283,
0.26636630296707153,
0.525742769241333,
1.1188549995422363,
0.2721116840839386,
-0.27790671586990356,
0.08977916091680527,
-0.3024427890777588,
0.2819554805755615,
-0.2767225205898285,
0.18006901443004608,
-0.32619553804397583,
-0.006410080008208752,
0.350972056388855,
0.12600083649158478,
0.06073696166276932,
-0.4915262758731842,
0.10101202130317688,
0.14495274424552917,
-0.13126757740974426,
-0.041329093277454376,
0.6976648569107056,
0.3849404454231262,
-0.26495257019996643,
0.2620898187160492,
-0.3879781663417816,
0.3392832279205322,
0.12293129414319992,
-0.022616516798734665,
-0.49713680148124695,
-0.8262604475021362,
0.3354998230934143,
-0.3331177830696106,
0.5372853875160217,
-0.44533124566078186,
0.15436221659183502,
-0.2872644364833832,
0.34635698795318604,
-0.26266351342201233,
-0.1445666253566742,
-0.26422473788261414,
-0.983942985534668,
-0.08948294073343277,
0.02713102102279663,
-0.00133617187384516,
0.15019777417182922,
0.17764994502067566,
-0.014167380519211292,
-0.22952541708946228,
-0.7799972891807556,
0.4609241783618927,
0.5264794230461121,
-0.38800448179244995,
0.14852064847946167,
0.2579408884048462,
0.23162448406219482,
0.39066654443740845,
-0.5107121467590332,
-0.20791329443454742,
0.1227499395608902,
-0.0094790980219841,
0.2265615612268448,
0.3802025616168976,
-0.16219352185726166,
0.09504316747188568,
-0.2642143666744232,
-0.019514797255396843,
0.4859325885772705,
0.057618383318185806,
0.15353640913963318,
0.5293524265289307,
0.1920725703239441,
-0.24663062393665314,
-0.19899408519268036,
0.17209668457508087,
0.22430872917175293,
0.04537585377693176,
-0.11944349855184555,
0.5338702201843262,
0.08348317444324493,
0.6099046468734741,
-0.2946464419364929,
0.6447256207466125,
0.5793930292129517,
0.3147139847278595,
0.22781354188919067,
-0.6546212434768677,
-0.2113933563232422,
-0.02779773809015751,
0.924310028553009,
0.4311378300189972,
-0.2206834852695465,
0.059295039623975754,
0.4402128756046295,
0.01284925825893879,
0.021541088819503784,
0.2500079274177551,
-0.1439182311296463,
0.1497170329093933,
0.06172338128089905,
-0.5326809883117676,
-0.6486915349960327,
0.009121508337557316,
-0.7465975880622864,
0.08925409615039825,
0.6632468700408936,
-0.42835548520088196,
-0.5207749605178833,
0.1087733656167984,
-0.2923002243041992,
0.055206771939992905,
-0.36054739356040955,
0.36122748255729675,
0.08857503533363342,
-0.10752406716346741,
0.19055980443954468,
0.19861285388469696,
0.30933865904808044,
-0.3807460367679596,
0.25298479199409485,
0.049723200500011444,
-0.16610966622829437,
-0.06942504644393921,
0.21641002595424652,
-0.2783222496509552,
-0.20897893607616425,
-0.28526416420936584,
-0.38891327381134033,
0.6316619515419006,
-0.33866843581199646,
0.44893336296081543,
0.09472234547138214,
-0.48139098286628723,
-0.46191319823265076,
-0.2684907913208008,
-0.2430681735277176,
-0.03495268523693085,
0.33269837498664856,
-0.007353886496275663,
0.34769207239151,
-0.7547750473022461,
-0.0770483985543251,
0.15588557720184326,
-0.038282785564661026,
-0.0838722363114357,
-0.12387152761220932,
0.5636363625526428,
0.40417423844337463,
0.5857052803039551,
0.18218646943569183,
0.12532486021518707,
-0.20708230137825012,
0.6314918994903564,
-0.536700963973999,
0.3278239369392395,
-0.44317448139190674,
-0.4549970328807831,
-0.27786827087402344,
-0.03204866498708725,
1.2897294759750366,
0.6673233509063721,
-0.48241767287254333,
0.22695113718509674,
0.4826726019382477,
0.6961265802383423,
0.4851055443286896,
-0.4110453426837921,
-0.2658494710922241,
-0.5441545248031616,
-0.27006006240844727,
-0.3384877145290375,
0.4993036985397339,
-0.3111434876918793,
-0.2920452058315277,
0.025139624252915382,
0.26948463916778564,
0.3752998411655426,
0.13083294034004211,
0.30868199467658997,
-0.40770936012268066,
0.1406090259552002,
-0.7806912064552307,
0.4101385474205017,
-0.49037790298461914,
0.3048507571220398,
-0.3450693190097809,
-0.12063299119472504,
0.374250590801239,
0.09650448709726334,
0.16873250901699066,
-0.46229562163352966,
0.19035615026950836,
0.03305297717452049,
0.08731041103601456,
0.015278059989213943,
0.09703684598207474,
-0.7407354116439819,
-0.5417502522468567,
0.1303659826517105,
0.37528279423713684,
-0.5680981874465942,
0.03225933760404587,
0.31509655714035034,
0.05361974239349365,
-0.14112533628940582,
-0.02576625905930996,
-0.5081201195716858,
0.09652931243181229,
-0.05073154717683792
] |
Objective: To provide an update to “Surviving Sepsis Campaign Guidelines for Management of Sepsis and Septic Shock: 2012. ” Design: A consensus committee of 55 international experts representing 25 international organizations was convened. Nominal groups were assembled at key international meetings (for those committee members attending the conference). A formal conflict-of-interest (COI) policy was developed at the onset of the process and enforced throughout. A stand-alone meeting was held for all panel members in December 2015. Teleconferences and electronic-based discussion among subgroups and among the entire committee served as an integral part of the development. Methods: The panel consisted of five sections: hemodynamics, infection, adjunctive therapies, metabolic, and ventilation. Population, intervention, comparison, and outcomes (PICO) questions were reviewed and updated as needed, and evidence profiles were generated. Each subgroup generated a list of questions, searched for best available evidence, and then followed the principles of the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) system to assess the quality of evidence from high to very low, and to formulate recommendations as strong or weak, or best practice statement when applicable. Results: The Surviving Sepsis Guideline panel provided 93 statements on early management and resuscitation of patients with sepsis or septic shock. Overall, 32 were strong recommendations, 39 were weak recommendations, and 18 were best-practice statements. No recommendation was provided for four questions. Conclusions: Substantial agreement exists among a large cohort of international experts regarding many strong recommendations for the best care of patients with sepsis. Although a significant number of aspects of care have relatively weak support, evidence-based recommendations regarding the acute management of sepsis and septic shock are the foundation of improved outcomes for these critically ill patients with high mortality. | [
-0.01555324625223875,
-0.0007939215283840895,
-0.010536923073232174,
0.023895248770713806,
0.015803316608071327,
0.009233801625669003,
0.00854420755058527,
0.0037513254210352898,
-0.012023543007671833,
0.01536060031503439,
0.007555626332759857,
0.01444941759109497,
-0.001483852043747902,
0.00946377869695425,
0.0020073174964636564,
-0.014434429816901684,
0.0025157900527119637,
0.01002954039722681,
0.01533648744225502,
-0.003927895799279213,
-0.008433236740529537,
-0.004896205849945545,
0.009949875064194202,
0.008166490122675896,
-0.029690075665712357,
-0.014293394051492214,
0.007422187831252813,
-0.00009635614696890116,
-0.0021229363046586514,
-0.011790852062404156,
0.029904166236519814,
0.01917533576488495,
0.012700749561190605,
-0.008075688034296036,
0.006768607534468174,
-0.015744898468255997,
-0.006747010163962841,
0.007884492166340351,
-0.01487396564334631,
-0.003953803330659866,
0.015895573422312737,
-0.01027629617601633,
0.001111422898247838,
0.004271000623703003,
-0.009715719148516655,
0.004366076085716486,
-0.011132623068988323,
-0.010578306391835213,
-0.0028623943217098713,
0.008052975870668888,
0.000910629634745419,
-0.006020405329763889,
-0.0016214755596593022,
-0.0012020862195640802,
-0.004937581717967987,
-0.016377896070480347,
0.0180489681661129,
-0.004309438169002533,
-0.02047901228070259,
-0.007739934138953686,
-0.005347819067537785,
-0.008471249602735043,
0.012351986020803452,
-0.0022829147055745125,
0.01876508817076683,
-0.06721082329750061,
0.025707870721817017,
0.00824168510735035,
-0.023909058421850204,
0.0039013936184346676,
0.021883394569158554,
0.014102073386311531,
0.007985902018845081,
-0.015455007553100586,
-0.012788449414074421,
-0.0006054104305803776,
0.007525218650698662,
-0.005077118054032326,
0.003668090095743537,
0.009785378351807594,
-0.01625044271349907,
-0.021711664274334908,
-0.005166268907487392,
0.0017489134334027767,
0.00893209595233202,
0.010385533794760704,
-0.007105871569365263,
0.017865706235170364,
0.00524721946567297,
-0.015167733654379845,
0.015314415097236633,
0.0018907752819359303,
-0.0003043804317712784,
0.01579909771680832,
-0.020525753498077393,
-0.022789835929870605,
-0.016374872997403145,
-0.019429165869951248,
-0.01174591388553381,
0.014844556339085102,
-0.014253376983106136,
0.005272604990750551,
0.018330706283450127,
0.03528429567813873,
-0.001446048030629754,
0.0021197861060500145,
0.008799046277999878,
-0.005885531660169363,
0.0049922652542591095,
0.007065157871693373,
0.002773615764454007,
0.02901398576796055,
0.027257539331912994,
-0.00027636694721877575,
0.0039194379933178425,
0.0026804236695170403,
0.009049627929925919,
0.020484309643507004,
0.013947948813438416,
-0.012724434025585651,
0.0214508306235075,
-0.01866563782095909,
-0.0017622853629291058,
0.010998261161148548,
-0.0014669906813651323,
0.017581408843398094,
0.003987639676779509,
0.0018671676516532898,
-0.016342755407094955,
0.0009321239776909351,
-0.011401891708374023,
0.006179586984217167,
0.0010168829467147589,
-0.0007685888558626175,
-0.006915506906807423,
0.0015118803130462766,
-0.00798621866852045,
0.0000887848436832428,
0.005166823044419289,
0.0009115515276789665,
-0.016095971688628197,
0.010191667824983597,
-0.00937841646373272,
0.008620530366897583,
-0.019682418555021286,
0.0073442296124994755,
-0.011853031814098358,
-0.010454648174345493,
0.003336995840072632,
0.017391391098499298,
0.032832227647304535,
0.008151003159582615,
0.0034257792867720127,
-0.007519816048443317,
0.012588409706950188,
0.0013957826886326075,
-0.01745082437992096,
-0.018194405362010002,
-0.017836052924394608,
-0.014344554394483566,
-0.008034581318497658,
0.007149826735258102,
-0.001039761584252119,
0.007656777277588844,
0.01583722233772278,
0.018071159720420837,
-0.021345214918255806,
0.011351274326443672,
-0.03532629832625389,
0.0051780627109110355,
-0.003293250221759081,
0.007823378778994083,
0.023070059716701508,
0.005417470820248127,
0.02263990417122841,
-0.018002089112997055,
0.01588766649365425,
0.005357198417186737,
-0.013334769755601883,
0.06695736944675446,
0.0011242949403822422,
0.005806232802569866,
-0.0047244359739124775,
0.016505016013979912,
0.006049760151654482,
-0.0028916357550770044,
-0.025152286514639854,
-0.0035891178995370865,
-0.016841337084770203,
0.002783004194498062,
0.007596805226057768,
-0.013392572291195393,
-0.012217925861477852,
-0.016755660995841026,
-0.00219300901517272,
0.0026172823272645473,
0.006693050265312195,
0.01431231014430523,
-0.02114190347492695,
0.024874813854694366,
0.011212482117116451,
-0.010370610281825066,
0.021663136780261993,
-0.0002755201421678066,
-0.020139947533607483,
0.020766649395227432,
0.009488178417086601,
-0.00464058481156826,
-0.017019230872392654,
-0.0017966777086257935,
0.02785160019993782,
-0.026314890012145042,
-0.0033009781036525965,
-0.018744714558124542,
0.008069994859397411,
0.00783363077789545,
0.014082979410886765,
0.015911612659692764,
-0.0020527716260403395,
-0.014897278510034084,
-0.0060646021738648415,
-0.002553163096308708,
-0.0023595078382641077,
0.011115089058876038,
0.014230897650122643,
0.04105401039123535,
-0.007936885580420494,
0.011058286763727665,
-0.007436612155288458,
-0.010692798532545567,
-0.0007552421884611249,
0.00932413712143898,
-0.011806748807430267,
-0.03455785661935806,
0.02065412327647209,
0.028687817975878716,
0.01457083597779274,
-0.007734356913715601,
0.005696221254765987,
-0.015916183590888977,
0.007813766598701477,
-0.0017478144727647305,
0.02396516688168049,
-0.009587984532117844,
0.00509549118578434,
-0.024735312908887863,
0.0068365721963346004,
-0.00942850112915039,
-0.0006279558874666691,
0.0022635089699178934,
0.0048302533105015755,
0.009107867255806923,
0.009892873466014862,
0.0002388239372521639,
0.029587211087346077,
-0.018010497093200684,
-0.018940459936857224,
0.007412506267428398,
0.021916687488555908,
0.00504779489710927,
0.009222510270774364,
0.005287764593958855,
-0.029213013127446175,
0.012022484093904495,
0.02451361157000065,
0.02305247075855732,
0.019262084737420082,
-0.005980809219181538,
0.012142972089350224,
0.008220212534070015,
0.007123260293155909,
-0.009741696529090405,
-0.011038852855563164,
-0.08140639960765839,
-0.002644987776875496,
-0.016708731651306152,
-0.002819126471877098,
0.00929203163832426,
-0.039178650826215744,
-0.007036086171865463,
-0.0069374870508909225,
-0.007968057878315449,
0.028373833745718002,
0.004835101775825024,
0.014576834626495838,
-0.014587793499231339,
-0.003331870539113879,
-0.005503542255610228,
-0.010416083969175816,
0.007338629104197025,
0.00026448722928762436,
-0.01855003833770752,
0.014556651934981346,
-0.025703098624944687,
-0.0035046334378421307,
0.012217968702316284,
-0.010992459952831268,
-0.005953650921583176,
0.011996401473879814,
0.014960354194045067,
-0.01129954494535923,
-0.025734176859259605,
0.006905385293066502,
-0.00966731645166874,
-0.0025476268492639065,
0.0008834910113364458,
-0.005129002500325441,
0.010673836804926395,
0.0025972630828619003,
-0.007277282420545816,
0.01212344504892826,
-0.01695404388010502,
-0.0014973909128457308,
0.017748555168509483,
0.0008653281256556511,
0.007565939798951149,
0.004352430813014507,
-0.01332727912813425,
0.009630447253584862,
0.00715811550617218,
0.006272187456488609,
0.010640936903655529,
0.0021274369210004807,
0.011081531643867493,
-0.014527885243296623,
-0.03898406773805618,
0.007696742191910744,
-0.02118845097720623,
-0.031855300068855286,
-0.021574772894382477,
-0.01102064922451973,
-0.007021595723927021,
-0.005544077139347792,
0.024019919335842133,
0.027675915509462357,
0.008097455836832523,
0.015558658167719841,
0.012077374383807182,
-0.01718500629067421,
0.013493238016963005,
0.017972152680158615,
0.00914602167904377,
0.002274867845699191,
0.0012850943021476269,
-0.007942242547869682,
0.008005749434232712,
-0.0015548886731266975,
0.00196521426551044,
-0.00947508867830038,
-0.014417294412851334,
-0.0030008412431925535,
-0.0021910076029598713,
-0.011177479289472103,
0.001901776995509863,
0.02526019513607025,
0.006236216984689236,
-0.015265034511685371,
-0.016052918508648872,
-0.00766237685456872,
0.01811639592051506,
0.003950165584683418,
0.013159103691577911,
-0.017148688435554504,
0.020062027499079704,
-0.00647306302562356,
-0.004583991132676601,
0.0073752389289438725,
0.00579035934060812,
0.026907674968242645,
-0.0234437957406044,
-0.009822282940149307,
0.012505073100328445,
0.008695323020219803,
-0.008638177067041397,
-0.008969709277153015,
0.008155477233231068,
-0.011120913550257683,
0.029032506048679352,
0.010325590148568153,
0.012568383477628231,
-0.015742354094982147,
-0.002615654841065407,
-0.006846284493803978,
-0.028013162314891815,
0.0023652988020330667,
0.0028666555881500244,
0.02959306165575981,
0.01003953069448471,
0.015083275735378265,
0.006974390707910061,
-0.0004281545989215374,
0.07272912561893463,
-0.005305349826812744,
-0.00037428736686706543,
-0.004776095971465111,
0.020157374441623688,
-0.005924898665398359,
-0.03186079114675522,
-0.008998092263936996,
-0.017297111451625824,
0.000471282284706831,
0.010300491005182266,
-0.014980505220592022,
-0.014317918568849564,
0.012915113009512424,
-0.0010428684763610363,
0.0024704725947231054,
-0.021864518523216248,
-0.0271137822419405,
-0.027469296008348465,
-0.0027584987692534924,
-0.00898985005915165,
-0.006261531729251146,
0.008347868919372559,
0.006280486937612295,
-0.00794166699051857,
-0.0022695441730320454,
-0.022395320236682892,
-0.013136259280145168,
-0.02353639155626297,
0.006193323992192745,
-0.0009018662385642529,
0.002006959170103073,
-0.006538809277117252,
-0.024357490241527557,
0.0000013739336282014847,
-0.013540968298912048,
0.0041213310323655605,
-0.002612895332276821,
-0.0027916457038372755,
0.009175820276141167,
-0.0028474554419517517,
-0.011523226276040077,
-0.02043004333972931,
0.013464991934597492,
0.020871005952358246,
0.03169097751379013,
-0.00514577142894268,
-0.009181511588394642,
-0.020418651401996613,
-0.0005859375232830644,
-0.009348834864795208,
0.0066809626296162605,
0.008563374169170856,
-0.007893278263509274,
-0.00009076995775103569,
-0.036919109523296356,
0.011620976030826569,
0.0010436782613396645,
-0.025751909241080284,
-0.0183513592928648,
-0.03404083102941513,
-0.010882552713155746,
-0.018645266070961952,
0.0021468447521328926,
-0.011074164882302284,
-0.012496989220380783,
0.02718895673751831,
-0.0030300780199468136,
-0.011418066918849945,
0.03955136239528656,
-0.036295391619205475,
0.004848304204642773,
0.004265598952770233,
-0.015259278938174248,
-0.014734705910086632,
-0.004232278559356928,
-0.008422491140663624,
0.011209655553102493,
0.012818994000554085,
-0.010035022161900997,
-0.024655481800436974,
0.013085514307022095,
-0.0016413889825344086,
-0.0038628028705716133,
0.02456611767411232,
0.018431873992085457,
0.0002948618493974209,
-0.07476679980754852,
-0.04213545471429825,
0.0057879905216395855,
-0.007907377555966377,
0.02905605547130108,
0.009453917853534222,
-0.00929439440369606,
0.04133547842502594,
0.013764441013336182,
-0.011199160479009151,
-0.007838691584765911,
0.0031643551774322987,
-0.006645321846008301,
-0.00021435413509607315,
0.010844005271792412,
0.00547053711488843,
-0.00969413947314024,
-0.0028687268495559692,
-0.018786165863275528,
-0.026734869927167892,
-0.01408323459327221,
-0.0022082284558564425,
-0.025855522602796555,
-0.002544639864936471,
0.009271437302231789,
-0.08155545592308044,
-0.004841712769120932,
0.014842444099485874,
-0.023371562361717224,
0.007576940581202507,
-0.015453365631401539,
0.01976241171360016,
-0.01778670959174633,
-0.0387057289481163,
-0.012167258188128471,
-0.010841893032193184,
-0.00866627600044012,
0.006111111957579851,
-0.02209658920764923,
-0.002989216009154916,
-0.006390413269400597,
0.026441019028425217,
-0.0019131805747747421,
-0.00657727662473917,
-0.00814029946923256,
0.010664064437150955,
0.013430147431790829,
-0.00767890177667141,
-0.00612004566937685,
-0.0040771025232970715,
0.01945187896490097,
-0.004998586606234312,
0.010128321126103401,
-0.009816483594477177,
-0.029709290713071823,
0.004217962734401226,
0.018673580139875412,
-0.010899937711656094,
-0.014176626689732075,
0.008866366930305958,
-0.006161287426948547,
-0.014966916292905807,
-0.009909003041684628,
-0.00965927541255951,
0.004691502079367638,
-0.004545530304312706,
0.011293957009911537,
0.009972109459340572,
0.03446436673402786,
0.022155340760946274,
0.0048319753259420395,
0.009707612916827202,
-0.006692839320749044,
0.019843045622110367,
-0.006911397445946932,
0.005619790870696306,
-0.0012881491566076875,
0.005865889601409435,
-0.013038073666393757,
0.004238309804350138,
0.006910260301083326,
-0.004708278924226761,
0.019837722182273865,
-0.0012617753818631172,
0.007607779465615749,
-0.009437588974833488,
-0.015241287648677826,
-0.0009247534908354282,
0.0722329318523407,
-0.009544654749333858,
0.003340872935950756,
0.003860992379486561,
-0.00869784876704216,
-0.0019873380661010742,
0.026022596284747124,
-0.014750034548342228,
-0.021944599226117134,
0.004747172351926565,
0.015249507501721382,
-0.00434242794290185,
0.006832678336650133,
0.014105469919741154,
0.018189705908298492,
-0.024604637175798416,
0.019552990794181824,
0.015697142109274864,
-0.00500963069498539,
0.021994004026055336,
0.027547894045710564,
-0.014034418389201164,
0.006776066962629557,
0.014556678012013435,
0.01094687171280384,
0.007166650611907244,
-0.0034667951986193657,
0.02161959744989872,
-0.009731331840157509,
0.012186042033135891,
-0.026934737339615822,
-0.027493953704833984,
0.0037926745135337114,
-0.003902031807228923,
-0.0012276377528905869,
-0.013160554692149162,
0.019014233723282814,
0.011251823976635933,
-0.007108708377927542,
0.013287348672747612,
-0.007795142941176891,
0.0030079644639045,
0.01023008394986391,
-0.020595071837306023,
0.01874599978327751,
0.022556614130735397,
-0.004910389427095652,
0.009508968330919743,
0.0003608665429055691,
0.006494385190308094,
0.013196732848882675,
0.003404368879273534,
0.0023151878267526627,
0.011073681525886059,
-0.015493901446461678,
-0.0063339886255562305,
-0.005046057980507612,
0.011416198685765266,
0.011280565522611141,
-0.007733573205769062,
0.002893042052164674,
-0.007498419843614101,
0.007340668700635433,
-0.011607363820075989,
0.0037061318289488554,
-0.013181154616177082,
0.023549504578113556,
-0.017611157149076462,
-0.02927706204354763,
0.012408239766955376,
-0.02553677186369896,
-0.012080859392881393,
0.007280844263732433,
-0.0065493411384522915,
0.011957544833421707,
0.004883188288658857,
0.00816689245402813,
-0.0002811248414218426,
0.018893010914325714,
0.006614820100367069,
-0.023444022983312607,
-0.00024373037740588188,
-0.01041147019714117,
-0.01379648968577385,
-0.012254651635885239,
-0.024740342050790787,
0.010755348950624466,
-0.016218069940805435,
-0.011184707283973694,
0.016000568866729736,
0.018971793353557587,
0.012706082314252853,
-0.006049805320799351,
0.015497863292694092,
0.010818766430020332,
0.03295545279979706,
0.017988333478569984,
-0.0009227241389453411,
-0.0034057828597724438,
0.00007139192894101143,
0.018312891945242882,
0.02458169125020504,
0.00141166802495718,
0.012026586569845676,
-0.018509965389966965,
-0.003453225363045931,
0.02077433094382286,
0.019646072760224342,
0.03610904514789581,
0.004278319887816906,
0.005282836966216564,
0.006140295881778002,
0.003661625785753131,
-0.007291001733392477,
-0.001234504859894514,
0.004823319613933563,
-0.016707245260477066,
-0.021627292037010193,
-0.008076717145740986,
-0.008817286230623722,
-0.00461061904206872,
0.006277747452259064,
-0.008542820811271667,
0.017014475539326668,
-0.02983248233795166,
-0.009550719521939754,
-0.0008929411415010691,
-0.003480862360447645,
0.019626088440418243,
-0.017920564860105515,
0.0018262248486280441,
0.005787104368209839,
0.001473922049626708,
-0.019684936851263046,
0.006860037799924612,
-0.00447596050798893,
0.016474679112434387,
0.010502621531486511,
0.014807365834712982,
-0.0008463182603009045,
0.01628211699426174,
0.005825147032737732,
0.009938370436429977,
0.027852226048707962,
0.009104881435632706,
-0.01598542556166649,
0.024629339575767517,
-0.025469187647104263,
0.010116360150277615,
0.0038013262674212456,
-0.005930596496909857,
-0.005838653072714806,
0.011039633303880692,
-0.0019660969264805317,
0.004621126223355532,
0.019476640969514847,
0.004507077392190695,
-0.01681223139166832,
-0.004366208799183369,
-0.017189353704452515,
0.0020331023260951042,
0.003390589728951454,
-0.007153935264796019,
0.0014724335633218288,
0.008464619517326355,
-0.028669103980064392,
-0.029442939907312393,
-0.0034385547041893005,
0.008294975385069847,
0.01686881110072136,
-0.016188088804483414,
-0.016384651884436607,
0.011143634095788002,
0.009949017316102982,
-0.01367909088730812,
-0.007747262716293335,
0.02402731217443943,
0.0033370007295161486,
0.005624725483357906,
0.032283782958984375,
-0.01095969695597887,
0.03194379806518555,
0.015856098383665085,
-0.016001015901565552,
0.0038989270105957985,
-0.006985374726355076,
-0.0079569723457098,
-0.003454693127423525,
-0.01479317992925644,
0.012604208663105965,
0.011510428972542286,
-0.029760178178548813,
-0.02137141302227974,
0.0038194565568119287,
0.0006431570509448647,
0.003292679088190198,
-0.006748500280082226,
-0.0132526196539402,
-0.005030803382396698,
-0.015290309675037861,
-0.0020046792924404144,
-0.010435453616082668
] | [
0.2735428512096405,
-0.116646908223629,
0.14993679523468018,
-0.32312771677970886,
-0.1282944232225418,
0.11539459973573685,
0.10936374217271805,
-0.35396677255630493,
0.18338850140571594,
0.23038533329963684,
-0.25566479563713074,
0.09359689801931381,
-0.13978217542171478,
0.03663027286529541,
0.021703774109482765,
0.5655568838119507,
0.4063301086425781,
0.09987898170948029,
-0.1485714614391327,
0.13098874688148499,
-0.25563928484916687,
-0.37573352456092834,
-0.07300128042697906,
0.17871181666851044,
-0.016980933025479317,
0.4501250088214874,
0.608448326587677,
-0.052887994796037674,
0.3690333664417267,
-0.15521857142448425,
0.4097435772418976,
0.46337154507637024,
0.32592347264289856,
-0.5406454205513,
-0.0552288219332695,
0.45714330673217773,
-0.098942831158638,
0.19130173325538635,
-0.09030595421791077,
-0.48045411705970764,
0.2403569519519806,
-0.06840480118989944,
-0.362596720457077,
0.2029542475938797,
-0.027706436812877655,
-0.4383545219898224,
-1.3883610963821411,
0.23007912933826447,
-0.35699528455734253,
0.4925248622894287,
-0.32753878831863403,
0.3838883936405182,
0.4453960359096527,
-0.09818655252456665,
-0.0740346610546112,
0.2850831151008606,
-0.2810668647289276,
-0.7829031944274902,
-0.19660961627960205,
-0.32491204142570496,
-0.03245507553219795,
-0.27897733449935913,
0.598969042301178,
0.1755448281764984,
-0.27227672934532166,
0.03948444500565529,
0.011708464473485947,
0.4944821298122406,
-0.08662105351686478,
-0.3664947748184204,
0.15281686186790466,
0.1252671182155609,
-0.5558322072029114,
0.3553168475627899,
-0.3430686593055725,
-0.3311106562614441,
0.13091185688972473,
-0.08140512555837631,
0.42905449867248535,
0.45562776923179626,
-0.0026143710128962994,
0.2818700075149536,
0.19873079657554626,
-0.489986777305603,
0.9281801581382751,
0.16627734899520874,
0.17878802120685577,
0.6904151439666748,
0.18251541256904602,
0.08921452611684799,
0.25959324836730957,
-0.5106839537620544,
0.4454466700553894,
0.10248824208974838,
0.6163877844810486,
-0.021341446787118912,
0.531725287437439,
-0.12399598956108093,
0.15087063610553741,
-0.47547098994255066,
0.6931213140487671,
0.3802281320095062,
-0.8307507038116455,
-0.17571918666362762,
-0.3203771412372589,
-0.14052549004554749,
-0.33992263674736023,
-1.1685802936553955,
-0.04743495211005211,
0.021629154682159424,
-0.3295058012008667,
0.004524983000010252,
-0.27331823110580444,
-0.12671762704849243,
-0.3333255648612976,
0.3623073697090149,
0.2757725715637207,
-0.21423710882663727,
0.08023566007614136,
0.4863353371620178,
-0.208665132522583,
0.7179800868034363,
-0.30110472440719604,
0.31025728583335876,
0.4465123414993286,
-0.001950071076862514,
0.3136569857597351,
0.3789645731449127,
-0.8650404214859009,
0.39371204376220703,
-0.24864351749420166,
0.285049170255661,
-0.17722995579242706,
-0.38314390182495117,
-0.13590271770954132,
-0.3239506185054779,
0.06827843934297562,
-0.03633318468928337,
0.4142346978187561,
0.24190451204776764,
-0.2147005945444107,
-0.6966606974601746,
-0.17747513949871063,
-0.13695479929447174,
-0.06584814935922623,
-0.24219027161598206,
-0.3260324001312256,
-0.263408362865448,
-0.5137176513671875,
-0.3116093873977661,
0.11344030499458313,
-0.2513650357723236,
-0.3762981593608856,
-0.42532408237457275,
0.09829970449209213,
0.7252421975135803,
-0.04619789496064186,
-0.2751750648021698,
-0.0771225318312645,
-0.2169848382472992,
0.7534564733505249,
0.276022732257843,
-0.6361708641052246,
-0.23189064860343933,
0.3878932297229767,
0.019726864993572235,
-0.2520976662635803,
0.15891164541244507,
0.48906615376472473,
-0.27019909024238586,
-0.03304148465394974,
-0.23287783563137054,
-0.0012487812200561166,
-0.18862038850784302,
0.14327934384346008,
0.09631845355033875,
0.4678657352924347,
0.5113484263420105,
0.06570202857255936,
0.20075635612010956,
-0.6611371636390686,
-0.11595748364925385,
-0.17802466452121735,
-0.4855450689792633,
0.17646069824695587,
-0.0008796303300186992,
-0.0020296690054237843,
-0.31795015931129456,
-0.254808247089386,
0.5747097134590149,
-0.4951525926589966,
-0.1621341109275818,
0.4731290638446808,
-0.6104996204376221,
1.41352117061615,
-0.7505754828453064,
-0.22524647414684296,
0.8668161034584045,
-0.01596592739224434,
0.09995076805353165,
0.09568865597248077,
0.1575695276260376,
0.6859833598136902,
-0.35129937529563904,
-0.7693563103675842,
0.18285131454467773,
0.04130644351243973,
-0.1763710379600525,
-0.813791036605835,
0.1781548410654068,
0.0794888362288475,
-0.29055914282798767,
0.017088597640395164,
-0.22801710665225983,
0.11415783315896988,
-0.20403148233890533,
-0.34234002232551575,
0.2591082751750946,
0.07126571238040924,
0.0009624304948374629,
0.83640456199646,
-0.3070025146007538,
-0.08917909115552902,
0.7864670157432556,
-0.20371034741401672,
0.07083041220903397,
0.42100363969802856,
0.2669268548488617,
0.7476024627685547,
-0.7538011074066162,
0.2285894900560379,
-0.019335806369781494,
0.17744925618171692,
-0.4118534028530121,
-0.022210683673620224,
0.17135775089263916,
-0.2035539299249649,
-0.10477758198976517,
0.4148249924182892,
-0.0274145919829607,
0.28645583987236023,
-0.0659453272819519,
-0.2292368859052658,
0.3928496241569519,
0.05129941552877426,
0.06323223561048508,
-0.0755685344338417,
0.1523796170949936,
-0.5941148996353149,
0.7880605459213257,
0.059247735887765884,
0.5931361317634583,
0.2574904263019562,
-0.2686211168766022,
0.309221476316452,
-0.067206472158432,
0.5267006158828735,
-0.7026752829551697,
-0.13496077060699463,
-0.037851929664611816,
-0.005092694889754057,
0.002452126005664468,
-0.21574236452579498,
0.21782340109348297,
0.7745432257652283,
-0.4719155430793762,
-0.19621673226356506,
-0.3971220552921295,
0.32458069920539856,
0.37324512004852295,
0.42948466539382935,
-0.028307342901825905,
-0.6050022840499878,
0.22708667814731598,
-0.24487939476966858,
-0.5249335169792175,
0.05765607953071594,
0.4561108350753784,
-0.36562588810920715,
-0.7145006656646729,
-0.13100558519363403,
0.16709661483764648,
0.12549592554569244,
-0.5207558870315552,
0.4355778396129608,
-0.011153718456625938,
-0.12905201315879822,
-0.28678300976753235,
-0.38713517785072327,
-0.12361545860767365,
0.1308097243309021,
0.019898710772395134,
0.10650410503149033,
-0.4470185935497284,
0.5857556462287903,
0.005144006107002497,
-0.5610160827636719,
0.6573007702827454,
0.2991120219230652,
0.46622851490974426,
-0.22635473310947418,
0.5863666534423828,
0.3901994228363037,
-0.3139723539352417,
0.08436613529920578,
-0.1713765561580658,
-0.2460838109254837,
0.09430020302534103,
-6.082020282745361,
-0.441228449344635,
-0.7018961310386658,
0.20629948377609253,
-0.5270794034004211,
0.4658908545970917,
0.9703388214111328,
-0.3199014663696289,
0.0864015445113182,
-0.1769396811723709,
0.20474450290203094,
0.38451337814331055,
0.1758497953414917,
0.11994046717882156,
0.03680988773703575,
0.6504104733467102,
0.25848835706710815,
0.2683068811893463,
0.022155920043587685,
0.1007622554898262,
0.13477376103401184,
-0.34475159645080566,
-0.018780821934342384,
0.16264933347702026,
0.298774391412735,
0.182687908411026,
-0.9599181413650513,
0.709124743938446,
0.2735752463340759,
0.40389829874038696,
0.3809947371482849,
-0.3566562831401825,
-0.3104688823223114,
-0.1485833078622818,
-0.0564802847802639,
0.10050178319215775,
0.22462676465511322,
0.2674211859703064,
-0.12915092706680298,
-0.47319266200065613,
-0.2541744112968445,
0.16619569063186646,
-0.013634251430630684,
-0.5534033179283142,
0.2548234164714813,
-0.22491233050823212,
0.2748219072818756,
0.26260805130004883,
-0.6647313833236694,
0.770844578742981,
0.32512572407722473,
0.09640192240476608,
0.23061221837997437,
-0.0036095764953643084,
0.2804740369319916,
-0.35614073276519775,
0.2289772480726242,
0.14641280472278595,
-0.4360063970088959,
0.2773205041885376,
0.12011616677045822,
-0.31352388858795166,
0.14550040662288666,
-0.5909205079078674,
-0.007996943779289722,
0.37671902775764465,
-0.872837245464325,
-0.5192042589187622,
0.03807055205106735,
-0.19304607808589935,
-0.16086669266223907,
0.37538474798202515,
-0.36770761013031006,
-0.7273644804954529,
-0.42217931151390076,
-0.5303017497062683,
0.9032493829727173,
0.11131133884191513,
0.22331008315086365,
-0.07965783774852753,
-0.3132931590080261,
0.09462171047925949,
0.1516767293214798,
-0.16365452110767365,
0.04313674196600914,
0.1932145059108734,
0.3786863088607788,
-0.2094140201807022,
-0.14915642142295837,
0.19259627163410187,
0.08748455345630646,
-0.4830304980278015,
-0.2682330310344696,
0.3296581208705902,
0.17118903994560242,
0.5620629191398621,
0.3698474168777466,
0.17214927077293396,
-0.07345882058143616,
-0.36736372113227844,
0.40811067819595337,
-0.07216282933950424,
-0.25500839948654175,
-0.5841476917266846,
-0.0007767481147311628,
-0.3479533791542053,
-0.555445671081543,
-0.1632993519306183,
0.8611910939216614,
-0.26302847266197205,
0.007023689802736044,
-0.1938922107219696,
0.01839921995997429,
-0.5721202492713928,
0.3032512366771698,
0.05269468203186989,
-0.1106705367565155,
-0.019717859104275703,
0.4495144486427307,
-0.24694648385047913,
0.08386612683534622,
0.6425771713256836,
0.2413204163312912,
0.8763561844825745,
-0.39976242184638977,
-0.10282967984676361,
-0.14397050440311432,
0.30749478936195374,
-0.012407981790602207,
0.35121139883995056,
0.15006010234355927,
0.5852504968643188,
-0.5573635697364807,
0.05239473283290863,
0.2703389823436737,
-0.4249240756034851,
-0.6028844118118286,
-0.02591041289269924,
0.0066626351326704025,
0.06774213165044785,
0.312960684299469,
0.25225725769996643,
-0.40010735392570496,
0.12323679029941559,
-0.1463305503129959,
0.07202453911304474,
-0.3521243929862976,
0.24169041216373444,
0.06120523437857628,
0.36040377616882324,
0.18025629222393036,
-0.10735489428043365,
0.10540825128555298,
0.14558850228786469,
-0.2566656768321991,
0.4498189389705658,
0.5070298910140991,
0.33577051758766174,
0.11181318014860153,
-0.5211379528045654,
0.21084095537662506,
0.08160293847322464,
-1.034683108329773,
-0.5441370010375977,
0.5066558122634888,
0.1331089287996292,
-0.2581152319908142,
-0.24918007850646973,
-0.32071223855018616,
-0.28688210248947144,
-0.06847810000181198,
-0.18876111507415771,
-0.4101202189922333,
-0.3819727301597595,
-0.08627080172300339,
0.12946033477783203,
-0.11493895202875137,
-0.10772492736577988,
0.03645971044898033,
0.19014698266983032,
0.15330125391483307,
-0.6626796126365662,
-0.2323269098997116,
0.24474234879016876,
0.5164080262184143,
0.0578690767288208,
0.3499946594238281,
-0.42827701568603516,
0.1502636820077896,
0.08159950375556946,
0.35401755571365356,
0.027855444699525833,
0.05595450848340988,
0.087614506483078,
-0.09932548552751541,
-0.2503996789455414,
-0.06279575079679489,
0.06882452219724655,
-0.11189314723014832,
-0.08415281772613525,
0.014295469038188457,
0.4945124089717865,
-0.28694337606430054,
-0.2304748296737671,
0.25646570324897766,
-0.34891462326049805,
-0.10028411448001862,
-0.20710648596286774,
-0.3067678213119507,
0.04431097209453583,
0.12186440825462341,
-0.23054881393909454,
-0.37684038281440735,
0.412348210811615,
-0.3096752166748047,
-0.14358042180538177,
-0.03160194307565689,
-0.6626402735710144,
-0.3289487361907959,
0.2655361592769623,
0.00019408369553275406,
0.019475053995847702,
0.04999600350856781,
-0.21888139843940735,
0.1142527237534523,
0.3551733195781708,
0.36576196551322937,
-0.5864793062210083,
-0.24412669241428375,
0.37060344219207764,
-0.6974525451660156,
0.023711174726486206,
0.32740694284439087,
0.12651327252388,
-0.26205602288246155,
-0.34860119223594666,
-0.5899410843849182,
-0.17755481600761414,
0.06016833335161209,
0.3399539291858673,
-0.5250310301780701,
0.3716893196105957,
0.3811931014060974,
-0.8539372682571411,
-0.29125726222991943,
0.13270947337150574,
-0.056830015033483505,
-0.2936508357524872,
-0.5365681648254395,
0.18155667185783386,
0.0847211480140686,
0.14523334801197052,
-0.02117147296667099,
-0.543194591999054,
0.2587856352329254,
0.3120526969432831,
-0.07724708318710327,
-0.5778060555458069,
-0.03523114696145058,
-0.3657437860965729,
0.11081885546445847,
-0.10905931890010834,
-0.3660075068473816,
-0.4008951783180237,
0.3741731345653534,
0.1608600616455078,
0.11767802387475967,
-0.569979727268219,
-0.3831110894680023,
-0.5698805451393127,
0.16368494927883148,
-0.17628313601016998,
0.7223961353302002,
0.5278342962265015,
-0.041862886399030685,
-0.3516949415206909,
-0.10891897976398468,
-0.14167779684066772,
0.11214754730463028,
0.2688058316707611,
-0.006219162605702877,
0.05802986025810242,
0.15292136371135712,
0.6852714419364929,
0.3964378535747528,
-0.7656442523002625,
-0.06172310933470726,
0.03472033515572548,
-0.5535150170326233,
-0.5462085604667664,
-0.23463788628578186,
0.38129255175590515,
-0.5726079940795898,
0.046483784914016724,
-0.3017987012863159,
0.08731592446565628,
-0.16318733990192413,
0.23479978740215302,
-0.40250667929649353,
0.20182539522647858,
-0.0822286605834961,
0.8386733531951904,
0.6856778860092163,
-0.5885583758354187,
-0.33293119072914124,
0.3467041552066803,
-0.4752790629863739,
-0.06288061290979385,
0.06188542768359184,
0.2574230134487152,
0.5467732548713684,
0.0649397075176239,
0.06060459092259407,
0.44285109639167786,
-0.8963714838027954,
-0.21532289683818817,
-0.43512868881225586,
-0.5437467694282532,
0.6313305497169495,
-0.05771162733435631,
-0.09209491312503815,
0.7581376433372498,
0.6501256823539734,
0.14751827716827393,
-0.33727750182151794,
0.20536234974861145,
0.12001638859510422,
0.8141468167304993,
0.07010631263256073,
1.0080323219299316,
0.26062077283859253,
0.731346070766449,
0.0972793772816658,
0.0901680514216423,
-0.11627569049596786,
-0.18745766580104828,
0.015833178535103798,
-0.16653867065906525,
-0.4777261018753052,
0.3430810570716858,
0.4264388382434845,
0.6983498930931091,
-0.014090967364609241,
0.11685791611671448,
-0.009772749617695808,
0.6270574927330017,
-0.014411360025405884,
0.18363308906555176,
-0.12115192413330078,
0.5608827471733093,
0.6063022613525391,
0.13680057227611542,
0.1920677125453949,
0.040344491600990295,
-0.1467205137014389,
0.18373019993305206,
-0.23157688975334167,
0.10719282925128937,
-0.12053406238555908,
0.256070613861084,
0.14169827103614807,
0.11916270107030869,
-0.2063332349061966,
0.13619200885295868,
-0.2631356418132782,
-0.06489118188619614,
0.5504369735717773,
-0.05046665668487549,
0.2574804723262787,
0.1767442524433136,
0.22895273566246033,
0.2691783607006073,
-0.6947188973426819,
0.3788817524909973,
-0.1397763192653656,
-0.8869300484657288,
0.4873895049095154,
0.2675941586494446,
0.2826536297798157,
0.2517765760421753,
-0.3173034191131592,
-0.12742428481578827,
0.06554823368787766,
-0.5598260164260864,
-0.09020452946424484,
0.10070841759443283,
-0.06146080419421196,
0.4958295524120331,
0.3735993504524231,
-0.14880412817001343,
-0.4305645227432251,
-0.6059352159500122,
-0.3112112581729889,
-0.08428924530744553,
0.07548107206821442,
0.009277625009417534,
0.3810020089149475,
0.21494875848293304,
0.3949304521083832,
0.4015010595321655,
-0.3222504258155823,
-0.2989882230758667,
0.058812450617551804,
0.17543312907218933,
0.20994120836257935,
0.5174724459648132,
-0.4332664906978607,
0.16476072371006012,
-0.7143052220344543,
-0.319853276014328,
0.4292205572128296,
0.03238283097743988,
-0.04718608036637306,
0.384484201669693,
-0.2502893805503845,
0.19982357323169708,
0.1900167167186737,
-0.26020073890686035,
0.015491819940507412,
-0.45297014713287354,
-0.4381878674030304,
-0.11478889733552933,
0.0925016850233078,
-0.01276624109596014,
-0.2238694578409195,
-0.093681201338768,
0.6460266709327698,
0.35997915267944336,
0.0938047468662262,
0.5761579871177673,
-0.5893784761428833,
-0.3276813328266144,
-0.11757706105709076,
0.1518862545490265,
-0.974814236164093,
0.056845784187316895,
0.20086707174777985,
0.04598123952746391,
0.14051198959350586,
-0.1431865692138672,
0.3154582679271698,
-0.15388670563697815,
-0.0009134493302553892,
-0.04607926681637764,
-0.05071151629090309,
0.29216840863227844,
-0.16736410558223724,
0.16340236365795135,
-0.9328972101211548,
0.02010655403137207,
0.5018947124481201,
-0.14218348264694214,
-0.3749512732028961,
-0.7182793617248535,
0.07565683871507645,
-0.163212388753891,
-0.14723703265190125,
-0.48237788677215576,
-0.186992347240448,
-0.16280914843082428
] |
The analysis of mitochondrial DNA (mtDNA) has been a potent tool in our understanding of human evolution, owing to characteristics such as high copy number, apparent lack of recombination, high substitution rate and maternal mode of inheritance. However, almost all studies of human evolution based on mtDNA sequencing have been confined to the control region, which constitutes less than 7% of the mitochondrial genome. These studies are complicated by the extreme variation in substitution rate between sites, and the consequence of parallel mutations causing difficulties in the estimation of genetic distance and making phylogenetic inferences questionable. Most comprehensive studies of the human mitochondrial molecule have been carried out through restriction-fragment length polymorphism analysis, providing data that are ill suited to estimations of mutation rate and therefore the timing of evolutionary events. Here, to improve the information obtained from the mitochondrial molecule for studies of human evolution, we describe the global mtDNA diversity in humans based on analyses of the complete mtDNA sequence of 53 humans of diverse origins. Our mtDNA data, in comparison with those of a parallel study of the Xq13.3 region in the same individuals, provide a concurrent view on human evolution with respect to the age of modern humans. | [
0.004261779598891735,
0.00799799244850874,
-0.02245553396642208,
0.005589199252426624,
0.015432657673954964,
-0.01324279885739088,
0.00883364025503397,
-0.0019441419281065464,
-0.013460829854011536,
-0.02109994739294052,
-0.012213964015245438,
0.01654278300702572,
-0.015462039969861507,
0.01985648274421692,
-0.01721617951989174,
0.03026285395026207,
-0.020457496866583824,
-0.0031635859049856663,
0.010964788496494293,
0.015173308551311493,
0.011110236868262291,
0.001891227439045906,
0.010362601839005947,
0.01452227309346199,
-0.0024165972135961056,
0.021125439554452896,
-0.017668966203927994,
0.009068302810192108,
0.005270778201520443,
-0.016125690191984177,
-0.013234474696218967,
-0.005112914368510246,
0.014892509207129478,
0.028852861374616623,
0.0019718906842172146,
0.013540815562009811,
0.005063561722636223,
0.028642090037465096,
0.04579061269760132,
-0.002810800215229392,
0.013215087354183197,
-0.006187879480421543,
0.008723096922039986,
-0.029142828658223152,
-0.008341347798705101,
-0.02845199964940548,
0.003095332533121109,
0.022056126967072487,
0.000840543769299984,
0.012703878805041313,
-0.018491756170988083,
-0.0023853834718465805,
-0.008934644982218742,
0.018733898177742958,
-0.006415514275431633,
-0.0024384292773902416,
0.01968657597899437,
-0.009651844389736652,
-0.0025869132950901985,
0.0014073331840336323,
0.004070264752954245,
-0.0049994164146482944,
0.023757845163345337,
-0.03571575880050659,
-0.016435198485851288,
-0.0673188716173172,
0.0024698437191545963,
0.014925151132047176,
-0.00013225944712758064,
0.015909967944025993,
-0.006797364912927151,
0.011053759604692459,
-0.029192548245191574,
0.013835139572620392,
0.00875183567404747,
-0.0006869025528430939,
-0.022623585537075996,
-0.004744198173284531,
0.05087133124470711,
0.014271524734795094,
0.00030434969812631607,
-0.02052384242415428,
0.040828026831150055,
0.028804542496800423,
-0.006662282161414623,
0.007236754521727562,
-0.009385091252624989,
0.012226089835166931,
0.02681872248649597,
-0.032680444419384,
0.0043786633759737015,
0.008619052357971668,
0.00475119287148118,
-0.01457936316728592,
-0.023751962929964066,
0.026922553777694702,
-0.01056077890098095,
0.016895882785320282,
0.04016578942537308,
0.026415299624204636,
-0.011163949966430664,
0.037354886531829834,
0.01957106962800026,
0.009150788187980652,
-0.003574647940695286,
0.010354205965995789,
-0.011148277670145035,
0.011350798420608044,
0.002369882073253393,
0.0028869761154055595,
0.011065279133617878,
-0.01929824985563755,
-0.020014621317386627,
0.02752099744975567,
0.01221451722085476,
0.0080341175198555,
-0.009658433496952057,
-0.01904643513262272,
0.008195159025490284,
-0.0002737186150625348,
-0.009377372451126575,
-0.013236609287559986,
-0.003984349779784679,
0.024094324558973312,
0.006276831962168217,
0.005330844782292843,
-0.009975227527320385,
0.00872169528156519,
0.001760017010383308,
0.01631908118724823,
-0.005078165791928768,
0.02607959695160389,
-0.014204109087586403,
-0.016303986310958862,
0.00602557510137558,
0.002500661415979266,
-0.025836985558271408,
-0.017664186656475067,
0.0018035941757261753,
-0.02565579116344452,
0.012702767737209797,
0.009581947699189186,
-0.004170553293079138,
0.007916649803519249,
0.011045960709452629,
-0.0024444980081170797,
-0.009359195828437805,
-0.00368516962043941,
0.016414320096373558,
0.0002739299088716507,
-0.0020774961449205875,
0.0010425117798149586,
-0.02557775005698204,
-0.006388759706169367,
0.0019337583798915148,
-0.013747208751738071,
-0.014673822559416294,
-0.03598957508802414,
-0.0031859627924859524,
0.01652856171131134,
-0.012978779152035713,
-0.0068959081545472145,
0.010858917608857155,
0.00861753337085247,
-0.006843189243227243,
-0.017074041068553925,
-0.030908683314919472,
-0.0028168975841253996,
-0.014211326837539673,
0.001839939970523119,
-0.005846233107149601,
-0.006257661152631044,
0.013188863173127174,
0.013675233349204063,
-0.007302038371562958,
-0.005450788419693708,
0.0053980378434062,
0.008311990648508072,
-0.006546269170939922,
0.06725826859474182,
-0.006191758904606104,
0.0014012516476213932,
0.005857761017978191,
0.009910034015774727,
0.0010298860725015402,
-0.005604872014373541,
0.011307569220662117,
-0.008985213004052639,
-0.002598351100459695,
-0.0022359159775078297,
-0.00582731980830431,
0.02074204385280609,
-0.04626099020242691,
0.021099276840686798,
-0.03528472036123276,
0.0021464419551193714,
0.016840625554323196,
-0.009957872331142426,
-0.0017448966391384602,
-0.016356468200683594,
-0.005421727430075407,
0.0010666809976100922,
0.04158570244908333,
-0.008253996260464191,
-0.01538174320012331,
0.011973386630415916,
0.04143926501274109,
0.0011835636105388403,
0.008006883785128593,
0.0060845911502838135,
0.016440095379948616,
0.010889418423175812,
0.00117508415132761,
0.002501105424016714,
-0.018394749611616135,
0.020591383799910545,
0.010219612158834934,
-0.006637192331254482,
0.019187485799193382,
-0.013280099257826805,
-0.0010222627315670252,
-0.0006940136663615704,
0.005313721485435963,
-0.010562986135482788,
0.012389466166496277,
0.0004100613296031952,
-0.0036323615349829197,
0.009865859523415565,
-0.03089151903986931,
-0.007821299135684967,
-0.0082926070317626,
-0.019552946090698242,
-0.008350086398422718,
0.0380796417593956,
-0.0010330709628760815,
-0.013636532239615917,
0.008429916575551033,
-0.011586877517402172,
0.016016507521271706,
-0.010212540626525879,
-0.02561277709901333,
-0.026979798451066017,
0.006941065192222595,
0.008316599763929844,
0.014760484918951988,
-0.0003517335280776024,
-0.005929326638579369,
0.032015733420848846,
0.009140728041529655,
-0.01834149844944477,
0.003840300254523754,
-0.005107922479510307,
-0.004322420340031385,
-0.017194779589772224,
-0.031332191079854965,
-0.004054673947393894,
0.0033440208062529564,
-0.0047237202525138855,
0.02223256044089794,
-0.007726770360022783,
0.004323883447796106,
0.007150381337851286,
-0.02380969375371933,
-0.020197561010718346,
-0.0010287270415574312,
-0.016940653324127197,
0.02607819065451622,
0.02863292023539543,
-0.016094673424959183,
-0.02137714996933937,
0.0020038674119859934,
-0.010680590756237507,
0.0076302457600831985,
-0.08112843334674835,
-0.00940512865781784,
-0.009476618841290474,
-0.044275879859924316,
0.009409112855792046,
-0.008665548637509346,
-0.0160384438931942,
-0.0089800413697958,
-0.008762681856751442,
0.001518766162917018,
0.026554547250270844,
0.009126313030719757,
-0.013701733201742172,
-0.0132883470505476,
-0.014924895018339157,
-0.007450633216649294,
0.013632262125611305,
-0.012476431205868721,
-0.000056898221373558044,
-0.030448319390416145,
-0.01451015193015337,
0.005856796633452177,
0.009479045867919922,
0.018691688776016235,
0.004505261778831482,
-0.028171878308057785,
0.04625975340604782,
-0.0023453119210898876,
-0.0022894805297255516,
0.008582442998886108,
0.01166617777198553,
-0.0021127343643456697,
0.03998315706849098,
-0.0004358402220532298,
-0.001651539234444499,
0.019606290385127068,
0.0035923763643950224,
-0.006076782010495663,
-0.024766800925135612,
0.031173542141914368,
0.0022037227172404528,
0.011400451883673668,
0.018474608659744263,
-0.009962160140275955,
0.02557346783578396,
0.020684855058789253,
0.00910593755543232,
-0.008323488757014275,
0.008215674199163914,
0.0069317808374762535,
0.022514579817652702,
-0.010330930352210999,
0.028223855420947075,
0.01042473316192627,
-0.01876797340810299,
-0.0031618871726095676,
-0.009929552674293518,
0.009712982922792435,
-0.018072962760925293,
0.0022825049236416817,
-0.017805293202400208,
-0.019250795245170593,
-0.026938609778881073,
-0.012249697931110859,
0.005886956583708525,
0.015395969152450562,
0.012307879514992237,
-0.021716345101594925,
0.018154432997107506,
-0.006832790561020374,
-0.0007207249291241169,
-0.021401463076472282,
0.013372824527323246,
-0.00286701787263155,
0.001319223316386342,
-0.007515983656048775,
-0.013644764199852943,
0.004563942551612854,
0.016165217384696007,
-0.0027964282780885696,
-0.0077344076707959175,
0.0022090356796979904,
0.01435087714344263,
-0.008569572120904922,
-0.019816473126411438,
-0.002900642342865467,
0.0004818085581064224,
0.017205141484737396,
0.016597429290413857,
-0.012185392901301384,
-0.015238629654049873,
-0.008071370422840118,
-0.00999888963997364,
0.010467598214745522,
-0.003877989947795868,
-0.013328652828931808,
-0.0005626324564218521,
-0.007533476687967777,
0.004853644408285618,
0.009511269629001617,
-0.008053912781178951,
0.009070320054888725,
0.015338018536567688,
-0.008341511711478233,
0.010374671779572964,
0.015562785789370537,
0.007279005367308855,
0.005273392889648676,
-0.0069232238456606865,
-0.009209933690726757,
0.0037265485152602196,
0.021800970658659935,
-0.004733990412205458,
0.0347779244184494,
0.020276373252272606,
0.023146353662014008,
-0.035997867584228516,
0.0008570030331611633,
0.07220863550901413,
0.006702243350446224,
0.008295346051454544,
-0.007345816120505333,
0.00420735776424408,
-0.023439859971404076,
0.012772046960890293,
0.012392734177410603,
-0.001636676723137498,
-0.025639304891228676,
0.010862501338124275,
0.022163134068250656,
-0.005104360170662403,
0.01437292154878378,
-0.005616538226604462,
0.008356018923223019,
-0.014141827821731567,
-0.008539179340004921,
-0.011333197355270386,
-0.02268379181623459,
-0.00936785526573658,
-0.023771271109580994,
-0.029317989945411682,
0.006320260465145111,
-0.03160754591226578,
0.0008729917462915182,
0.007930458523333073,
-0.013047386892139912,
-0.009774776175618172,
0.0014938637614250183,
0.005357999820262194,
0.023293109610676765,
-0.0015326759312301874,
0.018151480704545975,
0.0030057088006287813,
0.02829490602016449,
0.026067348197102547,
-0.00990387611091137,
-0.00918806716799736,
-0.006669219583272934,
-0.01986893080174923,
-0.009787701070308685,
0.030166758224368095,
0.010774871334433556,
0.01992744207382202,
0.003561020828783512,
0.0568474717438221,
-0.005596465431153774,
0.00591698894277215,
0.013587711378932,
-0.009577733464539051,
-0.009110278449952602,
0.008594430983066559,
0.013605248183012009,
-0.0008113058283925056,
-0.005873356945812702,
0.007269321940839291,
-0.0082966024056077,
0.0127559844404459,
-0.015701057389378548,
-0.03680265322327614,
-0.016366373747587204,
0.047712963074445724,
-0.011300859041512012,
0.01587975025177002,
-0.02168348804116249,
-0.042668864130973816,
-0.004651266150176525,
-0.022469734773039818,
-0.0017909142188727856,
0.03258957713842392,
-0.019601022824645042,
-0.008574230596423149,
-0.010067451745271683,
-0.012898437678813934,
0.0032258322462439537,
-0.00943651981651783,
-0.016331706196069717,
-0.005606921389698982,
0.031478747725486755,
0.0006292266771197319,
-0.021174278110265732,
-0.004433681722730398,
0.0328262522816658,
0.024434534832835197,
0.014868308790028095,
0.025090333074331284,
-0.07413191348314285,
-0.002172033302485943,
-0.007652975153177977,
-0.00515474658459425,
0.018795255571603775,
0.006861021742224693,
-0.017831312492489815,
0.008873757906258106,
0.021663064137101173,
-0.0029122827108949423,
0.0005829860456287861,
-0.03467395156621933,
-0.00851080846041441,
-0.007595047354698181,
0.012486533261835575,
0.017793094739317894,
-0.0007904362864792347,
0.00877704843878746,
-0.02981862984597683,
0.011157138273119926,
0.006620156113058329,
0.007210389710962772,
-0.032643821090459824,
0.010521288961172104,
-0.011870153248310089,
-0.08109880983829498,
-0.003601283300668001,
-0.01393971499055624,
0.018888387829065323,
-0.014401247724890709,
0.01166633889079094,
0.0201726034283638,
-0.0176699198782444,
0.007505713030695915,
-0.016611656174063683,
-0.01741827465593815,
0.007816556841135025,
0.007946053519845009,
0.003408495569601655,
0.015561926178634167,
-0.014213711023330688,
-0.01305517926812172,
0.01090843416750431,
-0.012378087267279625,
-0.025208113715052605,
-0.01086693350225687,
-0.015391858294606209,
-0.014180980622768402,
-0.025765936821699142,
-0.005210038740187883,
-0.010631359182298183,
0.0036381962709128857,
0.013445946387946606,
-0.006174465175718069,
0.010236767120659351,
0.0014380603097379208,
-0.027342453598976135,
-0.004300875589251518,
-0.03404071927070618,
0.0059578269720077515,
-0.016024300828576088,
-0.013465264812111855,
0.0017507467418909073,
-0.03604862093925476,
-0.006741581484675407,
-0.008697958663105965,
0.02298620156943798,
-0.01853647083044052,
0.01109379157423973,
-0.0023064794950187206,
-0.033134784549474716,
0.005807796958833933,
0.0005565811297856271,
-0.004684902727603912,
-0.015697605907917023,
-0.0006179852643981576,
-0.014038076624274254,
0.02028479240834713,
0.006006812676787376,
0.006882943212985992,
0.002259679138660431,
0.0034868065267801285,
0.017608454450964928,
0.011999865993857384,
0.010538391768932343,
0.0008480723481625319,
0.010885593481361866,
-0.0030053548980504274,
0.07226470857858658,
-0.010446046479046345,
-0.0015089111402630806,
0.0037270099855959415,
-0.00899695884436369,
-0.0011910911416634917,
-0.052179738879203796,
-0.0004695176612585783,
-0.019281145185232162,
-0.022349845618009567,
0.003722000401467085,
0.007345531135797501,
0.000018022023141384125,
0.010854728519916534,
-0.008174493908882141,
-0.0073222508653998375,
-0.008826769888401031,
-0.010593757964670658,
0.0005462912376970053,
-0.029813770204782486,
0.0018125250935554504,
0.02868017554283142,
-0.019411185756325722,
0.012361578643321991,
-0.007330055348575115,
-0.012148361653089523,
0.011715317144989967,
0.007164427544921637,
0.006845348980277777,
0.028845462948083878,
-0.0075165401212871075,
0.017564257606863976,
-0.001291843713261187,
0.0006709727458655834,
0.02205888368189335,
0.02414635196328163,
0.002024430315941572,
0.0011191467056050897,
-0.014851648360490799,
-0.0012773089110851288,
-0.014386964961886406,
0.0062286024913191795,
0.007595112547278404,
0.013503417372703552,
-0.011750264093279839,
0.012825286947190762,
-0.020118936896324158,
0.007805239409208298,
-0.0013534314930438995,
-0.007798526436090469,
0.0032095182687044144,
0.001846617553383112,
0.001378969638608396,
0.0006817311514168978,
0.00854733306914568,
-0.017126547172665596,
-0.034061580896377563,
0.02108381688594818,
-0.001558818155899644,
-0.0115956487134099,
0.016620460897684097,
-0.010385094210505486,
-0.02800825610756874,
-0.021428856998682022,
0.0201170202344656,
-0.02367536723613739,
0.013248040340840816,
-0.012492669746279716,
0.025596361607313156,
0.01638643443584442,
0.0010645543225109577,
0.007949704304337502,
0.004831450060009956,
0.03977668657898903,
0.0022753505036234856,
-0.008958103135228157,
0.006574433296918869,
-0.013437807559967041,
0.024118466302752495,
-0.0019356056582182646,
-0.007941125892102718,
0.019524656236171722,
0.0011882546823471785,
-0.015438330359756947,
-0.01176112424582243,
0.00873646978288889,
0.02492413856089115,
0.007861114107072353,
-0.0060264356434345245,
0.008932895958423615,
-0.0033743176609277725,
-0.003648164216428995,
0.0005323601653799415,
0.006192553788423538,
0.011592489667236805,
0.03335175663232803,
0.010281773284077644,
0.015649445354938507,
0.013476582244038582,
0.006380373612046242,
0.01903502829372883,
-0.00912039540708065,
0.0012888945639133453,
0.0023403228260576725,
-0.021068837493658066,
-0.0013955826871097088,
0.0014822219964116812,
-0.006353631615638733,
0.017834443598985672,
0.013253852725028992,
0.010365935042500496,
-0.02001310884952545,
-0.013930252753198147,
-0.028816215693950653,
0.0001655671512708068,
-0.0065468186512589455,
-0.0064544836059212685,
-0.047576695680618286,
0.01834837906062603,
-0.01228722371160984,
-0.02269771881401539,
-0.008252810686826706,
-0.010982301086187363,
0.019142556935548782,
0.0009134585270658135,
-0.000058552250266075134,
-0.014854317530989647,
0.008326619863510132,
0.008296774700284004,
0.018874190747737885,
-0.0004567215219140053,
-0.00917568989098072,
0.02840496599674225,
0.022725442424416542,
-0.00026824744418263435,
-0.029494553804397583,
-0.009270109236240387,
-0.0007620258256793022,
-0.010558918118476868,
-0.0028751573991030455,
0.030487075448036194,
-0.021449999883770943,
-0.0072358837351202965,
-0.0019410192035138607,
0.011072778142988682,
-0.0015573840355500579,
0.006516727618873119,
0.02923431620001793,
0.008052155375480652,
-0.007773751392960548,
0.0014686619397252798,
0.02403390407562256,
-0.016357358545064926,
-0.007153309881687164,
-0.00644182413816452,
0.010666275396943092,
0.018128085881471634,
0.0021949750371277332,
0.00777958519756794,
-0.001653715269640088,
0.0012284942204132676,
0.026885278522968292,
-0.01814812421798706,
0.01077185571193695,
0.000840027816593647,
0.009136582724750042,
-0.003914908040314913,
0.025717444717884064,
-0.02058032527565956,
0.006190095096826553,
0.0007867887616157532,
-0.00442797876894474,
-0.018586009740829468,
0.01975375972688198,
-0.01905839517712593,
-0.010490022599697113,
-0.0025216718204319477,
0.008215060457587242,
-0.007327667437493801,
0.01080408040434122,
0.008503147400915623,
0.00922661554068327,
-0.014150423929095268,
-0.009070524014532566,
-0.001138783060014248,
-0.0022206727880984545,
-0.0008299336768686771,
0.014671457931399345,
0.017821723595261574,
0.01980680786073208,
0.0024181799963116646,
0.0025677732191979885,
-0.017169438302516937,
-0.007291682064533234,
-0.016336767002940178,
-0.002590848132967949,
0.021278057247400284,
-0.015510942786931992,
0.010288335382938385,
0.003201441839337349,
0.018412258476018906,
-0.007759785745292902
] | [
-0.14140181243419647,
-0.039479173719882965,
-0.7742385864257812,
-0.08981495350599289,
0.12628667056560516,
0.3222052752971649,
0.45210951566696167,
-0.007679044269025326,
0.3672892451286316,
-0.8326374888420105,
0.16666357219219208,
-0.0272502601146698,
-0.10658968240022659,
0.31695792078971863,
-0.618156373500824,
0.7128039002418518,
0.4078236222267151,
0.15987363457679749,
-0.4202978312969208,
-0.2813892960548401,
-0.1102658212184906,
-0.31344181299209595,
0.03070252388715744,
0.2269865870475769,
-0.04878300428390503,
-0.173376202583313,
0.5328800678253174,
0.006520366296172142,
0.17372237145900726,
0.10263475030660629,
-0.4380972981452942,
0.25678056478500366,
-0.31955623626708984,
-0.3653716444969177,
-0.6066320538520813,
-0.45366162061691284,
-0.4765722453594208,
0.1472964882850647,
0.26148858666419983,
0.0906824842095375,
-0.08836901932954788,
-0.14782200753688812,
-0.059748679399490356,
0.8943021893501282,
-0.5495039820671082,
-0.3819403648376465,
-1.396065354347229,
1.0812104940414429,
-0.7611125111579895,
0.2346748411655426,
-0.3729841411113739,
0.05993906408548355,
0.3503763675689697,
0.4203609824180603,
-0.08093508332967758,
0.5735726356506348,
-0.6090039014816284,
-0.03764728084206581,
0.2649265229701996,
-0.24467675387859344,
0.10176707059144974,
0.28928062319755554,
-0.1887858361005783,
0.2781206965446472,
0.3302921950817108,
-0.043306611478328705,
0.19903059303760529,
-0.37401705980300903,
-0.7885861992835999,
-0.3776371479034424,
0.47305360436439514,
0.06326164305210114,
-0.19558899104595184,
0.6085324883460999,
-0.28442108631134033,
-0.15171773731708527,
-0.5057357549667358,
0.15830552577972412,
0.31858211755752563,
0.0006897944258525968,
-0.14184615015983582,
0.08355596661567688,
-0.28973397612571716,
-0.268502801656723,
0.5439372062683105,
0.177621990442276,
-0.24338027834892273,
0.4689127504825592,
-0.4975416958332062,
-0.08396980911493301,
0.31358885765075684,
-0.2478613555431366,
0.028162134811282158,
0.27503424882888794,
0.49830588698387146,
0.4313107132911682,
0.20720930397510529,
0.13921409845352173,
0.2555308938026428,
0.2626708745956421,
-0.502314567565918,
-0.28729090094566345,
0.4460316002368927,
-0.3456494212150574,
-0.4601483643054962,
-0.44769424200057983,
-0.1838051974773407,
-0.03733205795288086,
-0.39472514390945435,
0.08779637515544891,
-0.41107362508773804,
0.11534810066223145,
0.05303649231791496,
-0.2907894551753998,
-0.43275684118270874,
-0.09203460812568665,
0.1730400025844574,
-0.3466985821723938,
-0.07321958243846893,
-0.0627722293138504,
-0.793613076210022,
1.1550922393798828,
-0.1269744634628296,
0.3238827884197235,
-0.2887252867221832,
0.2054450362920761,
0.9679086208343506,
0.3930138349533081,
-0.2840502858161926,
0.12275946885347366,
0.25872552394866943,
0.7869701385498047,
0.26670873165130615,
0.08033036440610886,
-0.05209304392337799,
-0.2509699761867523,
0.3555748462677002,
0.042507272213697433,
0.3763063848018646,
-0.12856385111808777,
-0.658725917339325,
-0.9339621663093567,
0.15499119460582733,
0.1634955257177353,
0.32643356919288635,
-0.40935906767845154,
-0.12169686704874039,
-0.22787649929523468,
0.05792543292045593,
-0.23793825507164001,
0.16580113768577576,
-0.2505384087562561,
-0.9996874928474426,
-0.5067232251167297,
-0.1041906476020813,
0.35157328844070435,
-0.12241383641958237,
-0.1268460899591446,
-0.011434309184551239,
0.26849454641342163,
0.34516918659210205,
-0.12692563235759735,
-0.13299265503883362,
-0.3494890332221985,
0.3302149474620819,
-0.3074280619621277,
1.1139872074127197,
1.0658410787582397,
-0.22945626080036163,
0.029478643089532852,
-0.06134791672229767,
-0.3087279498577118,
0.5112380385398865,
-0.27961888909339905,
-0.6035564541816711,
-0.06645677238702774,
-0.23080366849899292,
-0.053224869072437286,
0.26418590545654297,
0.23443882167339325,
-0.47718146443367004,
0.039537422358989716,
0.19340147078037262,
-0.05136898159980774,
0.47649893164634705,
-0.08302655071020126,
0.5441989898681641,
-0.24263428151607513,
-1.1800645589828491,
-0.04695327207446098,
-0.1595384180545807,
-0.6618661284446716,
0.256334125995636,
-0.8316258192062378,
1.2205344438552856,
-0.14201213419437408,
-0.00650870893150568,
1.4317220449447632,
0.15353940427303314,
0.016871895641088486,
-0.3156384825706482,
0.14463427662849426,
0.46287667751312256,
-0.4037456512451172,
-0.3525656759738922,
-0.21562616527080536,
0.6456564664840698,
-0.3734497129917145,
-0.04447044059634209,
-0.20400002598762512,
-0.045344918966293335,
-0.3705027103424072,
0.03338680416345596,
0.034529685974121094,
-0.10970913618803024,
0.3877478241920471,
-0.2646979093551636,
0.17149843275547028,
-0.04621206223964691,
0.05257687717676163,
0.6602073311805725,
-0.42548635601997375,
0.49815014004707336,
0.006578273605555296,
-0.24426308274269104,
0.43895721435546875,
0.448673278093338,
0.2841532826423645,
1.0736939907073975,
-0.30356812477111816,
0.17648662626743317,
-0.26547935605049133,
0.6761313080787659,
-0.3205345571041107,
-0.3059229850769043,
-0.2086380273103714,
-0.12451102584600449,
-0.06568729132413864,
-0.2008741945028305,
0.4669685661792755,
-0.020983591675758362,
0.5847291350364685,
-0.39645838737487793,
-0.08513648808002472,
-0.2342531681060791,
-0.2943589389324188,
0.012146929278969765,
-0.1067008227109909,
-0.3499961495399475,
-0.12579984962940216,
0.11555258929729462,
0.16781462728977203,
0.0007535364129580557,
-0.22136536240577698,
-0.0012218529591336846,
-0.21086283028125763,
0.37924474477767944,
-0.2664523124694824,
0.30982086062431335,
-0.012411415576934814,
0.3011567294597626,
-0.47407951951026917,
0.11851225048303604,
-0.47260645031929016,
-0.32256022095680237,
-0.8637607097625732,
-0.5930103659629822,
-0.872067391872406,
0.9732951521873474,
0.8552167415618896,
1.037207007408142,
0.15692520141601562,
-0.1449107527732849,
0.22118021547794342,
-0.03337894007563591,
-0.5226815938949585,
-0.13083016872406006,
0.19022701680660248,
-0.21015682816505432,
-0.14189578592777252,
-0.03926428407430649,
0.3074556291103363,
0.18935279548168182,
-0.30766040086746216,
-0.922641932964325,
-0.23780682682991028,
0.524200439453125,
-0.3178595006465912,
0.01026099268347025,
0.1001405119895935,
-0.22259876132011414,
0.42299535870552063,
-0.06553389877080917,
-0.5916006565093994,
0.2608441710472107,
0.21729961037635803,
0.22942093014717102,
-0.14604827761650085,
-0.07062983512878418,
-0.5499124526977539,
-0.4998875856399536,
0.012433366850018501,
-0.11427409946918488,
-0.07786981016397476,
0.17740049958229065,
0.5427573919296265,
0.16000919044017792,
0.0731487050652504,
-5.86736536026001,
-0.12080519646406174,
-0.3353443443775177,
-0.24536025524139404,
0.13070574402809143,
-0.08528348803520203,
0.846641480922699,
0.026164567098021507,
0.44884902238845825,
-0.13778932392597198,
0.273240864276886,
0.2984657287597656,
0.2763807475566864,
0.14968335628509521,
0.013171368278563023,
-0.3362273573875427,
0.12464769184589386,
0.2325926423072815,
0.2896149456501007,
0.3622055649757385,
0.2515653371810913,
-0.31132227182388306,
0.049891337752342224,
0.5044035911560059,
-0.017819764092564583,
0.22980795800685883,
-0.4503571689128876,
-0.23904496431350708,
0.2176506519317627,
-0.2664567530155182,
-0.15159350633621216,
-0.9401047825813293,
-0.21215935051441193,
-0.21841152012348175,
0.03647927567362785,
0.190345898270607,
0.2732337415218353,
0.02604457177221775,
0.3589102029800415,
0.11675043404102325,
0.27797189354896545,
0.375189870595932,
0.1930190622806549,
-0.4387567639350891,
0.22701703011989594,
-0.4171348810195923,
-0.19075746834278107,
0.1376008838415146,
0.07168268412351608,
0.6737805008888245,
-0.47122350335121155,
-0.03778313100337982,
0.25638002157211304,
-0.0007199932588264346,
0.0906892642378807,
-0.2703855037689209,
0.28712329268455505,
-0.13797405362129211,
0.040806740522384644,
0.10351694375276566,
0.03350168839097023,
-0.7040554285049438,
0.17234326899051666,
-0.5477479100227356,
-0.6867696046829224,
0.2996859550476074,
-0.44718530774116516,
-0.38115134835243225,
-0.30732882022857666,
0.3491194546222687,
-0.24585720896720886,
0.15383979678153992,
0.2938867211341858,
-0.13577699661254883,
0.3590649366378784,
-0.45568951964378357,
-0.14835260808467865,
-0.1275584101676941,
-0.4698925316333771,
0.002727775601670146,
-0.7608133554458618,
-0.7196030020713806,
0.04399612173438072,
-0.1804208606481552,
0.13827797770500183,
-0.30176621675491333,
-0.676510751247406,
-0.0005444361595436931,
-0.4512059986591339,
-0.03102150559425354,
0.6657235026359558,
-0.793484091758728,
0.3193944990634918,
0.47107723355293274,
0.599701464176178,
0.3027563691139221,
0.4216691255569458,
0.3487624526023865,
0.6494079828262329,
0.12731455266475677,
0.7803717255592346,
-0.04626389965415001,
-0.16061878204345703,
-0.34637120366096497,
-0.18171770870685577,
-0.24032039940357208,
-0.5548537969589233,
0.7257188558578491,
0.5872476696968079,
-0.45871710777282715,
-0.15229623019695282,
0.10229457914829254,
0.16423000395298004,
0.014324077405035496,
0.3336920738220215,
-0.21920713782310486,
0.2021678388118744,
-0.2651847004890442,
0.7923146486282349,
0.16302889585494995,
-0.2574649155139923,
-0.21371431648731232,
-0.9606553912162781,
0.37204787135124207,
0.223026305437088,
-0.7889547944068909,
0.41210123896598816,
0.6594407558441162,
-0.18689827620983124,
-0.5267903208732605,
0.044209275394678116,
0.7413275241851807,
-0.06450597941875458,
0.2351510226726532,
0.27093827724456787,
-0.15069502592086792,
-0.17224451899528503,
0.20077025890350342,
-0.006598964333534241,
-0.3720596730709076,
0.5716114044189453,
-0.3428557217121124,
-0.20441830158233643,
-0.13291384279727936,
-0.10311082750558853,
0.39694714546203613,
-0.32220810651779175,
-0.08696456998586655,
-0.22083045542240143,
-0.31311318278312683,
-0.1962687373161316,
-0.35020390152931213,
0.05251940339803696,
0.17704297602176666,
-0.04378633201122284,
0.018916169181466103,
0.35329005122184753,
0.4309694468975067,
0.028228534385561943,
-0.6966415047645569,
0.05196789279580116,
-0.25409308075904846,
-0.4764600098133087,
0.26105260848999023,
-0.36664098501205444,
0.2721129059791565,
0.11749861389398575,
0.010143280029296875,
-0.0852346420288086,
0.4402996301651001,
-0.32179582118988037,
-0.1586984395980835,
0.22581681609153748,
-0.4837138056755066,
-0.06460224092006683,
-0.06095348298549652,
-0.030592715367674828,
0.2601855993270874,
-0.5960602760314941,
0.19922880828380585,
0.017668109387159348,
-0.2525947690010071,
-0.1793368011713028,
0.7024307250976562,
0.3289561867713928,
0.30127179622650146,
-0.18330323696136475,
0.1294415295124054,
-0.23286232352256775,
0.03267226368188858,
-0.026394397020339966,
0.09395658224821091,
-0.01929665543138981,
-0.33372393250465393,
-0.1889912635087967,
0.2030690610408783,
0.16916655004024506,
0.044394563883543015,
0.21629421412944794,
-0.09431371092796326,
0.39849016070365906,
0.08273714035749435,
-0.06285736709833145,
0.22129987180233002,
0.6092798113822937,
-0.14673051238059998,
-0.4847596287727356,
-0.01812143623828888,
-0.36765342950820923,
-0.7342361807823181,
-0.378954142332077,
-0.475663423538208,
0.17951998114585876,
0.3246782124042511,
-0.15647906064987183,
-0.01930234581232071,
0.3770489990711212,
0.09693112969398499,
0.21638530492782593,
0.34441983699798584,
0.02180696465075016,
0.6191197037696838,
-0.019790664315223694,
0.22133363783359528,
0.12686939537525177,
0.1373542994260788,
0.40114861726760864,
-0.8291460275650024,
0.0032367785461246967,
0.19667382538318634,
0.17246855795383453,
-0.3550146818161011,
-0.06737718731164932,
0.2811870276927948,
-0.15732312202453613,
-0.6207316517829895,
0.057597629725933075,
0.4880842864513397,
-0.1373942494392395,
-0.06800617277622223,
0.7771939635276794,
0.3105599880218506,
-0.07801445573568344,
0.7029658555984497,
-0.25188949704170227,
0.03175508975982666,
0.13171698153018951,
-0.5924651622772217,
-0.6332529187202454,
0.15074819326400757,
-0.03293195739388466,
-0.3327868580818176,
-0.037944622337818146,
0.47443777322769165,
0.6050431132316589,
0.2683125436306,
-0.03585799038410187,
-0.5508540868759155,
-0.1134522557258606,
0.31997251510620117,
-0.054719697684049606,
-0.40466979146003723,
-0.08447308093309402,
-0.4181351661682129,
0.5812463760375977,
0.009668653830885887,
-0.8224402070045471,
-0.651412308216095,
0.6898078918457031,
0.005322884302586317,
-0.21497172117233276,
-0.23990324139595032,
0.19050635397434235,
0.23740454018115997,
-0.08837531507015228,
0.1318954974412918,
0.036533504724502563,
0.6360883712768555,
-0.2740507125854492,
0.18210698664188385,
-0.14617571234703064,
-0.22164446115493774,
1.0160781145095825,
-0.7504517436027527,
-0.16106870770454407,
-0.22659651935100555,
0.3700023293495178,
-0.32725900411605835,
0.1515381783246994,
-0.3825584948062897,
-0.37579795718193054,
-0.2340543568134308,
-0.4951462745666504,
-0.3643023669719696,
0.33486342430114746,
-0.08350040018558502,
0.22179345786571503,
0.8071500062942505,
0.04814784973859787,
-0.25098294019699097,
-0.495502769947052,
0.3882027268409729,
0.3319089114665985,
-0.6000546216964722,
0.3669118583202362,
0.038481540977954865,
0.3786170780658722,
0.5880047082901001,
-0.25063493847846985,
0.0684218630194664,
0.05665769800543785,
0.18394745886325836,
0.315204381942749,
0.46961548924446106,
-0.435817688703537,
0.30032962560653687,
0.15358883142471313,
-0.072969950735569,
0.6739612817764282,
0.03205840662121773,
0.15942709147930145,
0.5435112714767456,
0.28063467144966125,
-0.2533594071865082,
-0.29666605591773987,
0.8352319002151489,
0.15354624390602112,
0.4240029752254486,
-0.11937679350376129,
0.2231895476579666,
0.3279367685317993,
0.3979056179523468,
-0.0835271030664444,
0.38801535964012146,
-0.07456636428833008,
-0.11989469081163406,
-0.023299291729927063,
-0.25841447710990906,
0.5547966957092285,
0.4870615303516388,
0.29511579871177673,
0.3831641972064972,
-0.7025113105773926,
0.17384073138237,
-0.04120941087603569,
0.20821689069271088,
-0.2686588168144226,
-0.0909004807472229,
-0.33326268196105957,
0.5262529850006104,
0.09902998059988022,
-0.34193477034568787,
0.10452573746442795,
0.5738083720207214,
-0.02916792221367359,
-0.37002402544021606,
0.6701790690422058,
-0.4279543459415436,
-0.5753827095031738,
0.05787357687950134,
0.04167688265442848,
1.1158533096313477,
-0.13115964829921722,
0.3073137402534485,
-0.15980367362499237,
-0.08159224689006805,
0.7500243782997131,
-0.41761112213134766,
0.19782252609729767,
-0.39407017827033997,
-0.005806552246212959,
0.038940150290727615,
-0.33932170271873474,
-0.17730851471424103,
0.4901450276374817,
-0.31353968381881714,
0.1835138350725174,
0.03486965596675873,
-0.3314242362976074,
-0.12527382373809814,
-0.1612706035375595,
-0.7258013486862183,
-0.18777276575565338,
-0.98538738489151,
-0.20118503272533417,
-0.10071074962615967,
-0.0462358221411705,
0.15157660841941833,
0.11605757474899292,
0.3083706796169281,
0.6140493154525757,
-1.0154190063476562,
-0.06168976426124573,
-0.028304168954491615,
-0.3540250062942505,
-0.5737950205802917,
0.009533586911857128,
0.21230873465538025,
0.2918979227542877,
0.26162537932395935,
-0.1152111142873764,
0.5106595754623413,
0.20632930099964142,
0.20875415205955505,
-0.726944088935852,
0.7539107799530029,
-0.19269397854804993,
-0.14551089704036713,
-0.4793442487716675,
0.0401909276843071,
1.0249459743499756,
-0.16840359568595886,
-0.30092760920524597,
-0.038855310529470444,
0.02638842724263668,
0.07815549522638321,
-0.16150128841400146,
-0.4221503734588623,
0.5936320424079895,
0.23686634004116058,
0.39142972230911255,
-0.6439063549041748,
0.3658027946949005,
0.22240065038204193,
-0.4679485857486725,
0.02388184331357479,
0.5477715730667114,
0.2769748270511627,
-0.7631286382675171,
0.6421394348144531,
0.029230929911136627,
0.5297786593437195,
-0.13507945835590363,
0.21657514572143555,
-0.21925395727157593,
-0.14042164385318756,
-0.25606217980384827,
-0.04976422339677811,
0.22482217848300934,
-0.49415624141693115,
-0.2517533600330353,
0.12901745736598969,
-0.21466167271137238,
0.2736186981201172,
-0.0025098160840570927,
0.043813612312078476,
-0.3744408190250397,
-0.4900457561016083,
-0.5087770819664001,
0.32619723677635193,
-0.13913796842098236,
0.5786759853363037,
-0.13509611785411835,
0.20511774718761444,
-0.6783496141433716,
-0.6001190543174744,
0.23165130615234375,
-0.823322594165802,
0.25775018334388733,
0.1912062019109726
] |
OBJECTIVE IL-15 is an inflammatory cytokine secreted by many cell types. IL-15 is also produced during physical exercise by skeletal muscle and has been reported to reduce weight gain in mice. Contrarily, our findings on IL-15 knockout (KO) mice indicate that IL-15 promotes obesity. The aim of this study is to investigate the mechanisms underlying the pro-obesity role of IL-15 in adipose tissues. METHODS Control and IL-15 KO mice were maintained on high fat diet (HFD) or normal control diet. After 16 weeks, body weight, adipose tissue and skeletal mass, serum lipid levels and gene/protein expression in the adipose tissues were evaluated. The effect of IL-15 on thermogenesis and oxygen consumption was also studied in primary cultures of adipocytes differentiated from mouse preadipocyte and human stem cells. RESULTS Our results show that IL-15 deficiency prevents diet-induced weight gain and accumulation of lipids in visceral and subcutaneous white and brown adipose tissues. Gene expression analysis also revealed elevated expression of genes associated with adaptive thermogenesis in the brown and subcutaneous adipose tissues of IL-15 KO mice. Accordingly, oxygen consumption was increased in the brown adipocytes from IL-15 KO mice. In addition, IL-15 KO mice showed decreased expression of pro-inflammatory mediators in their adipose tissues. CONCLUSIONS Absence of IL-15 results in decreased accumulation of fat in the white adipose tissues and increased lipid utilization via adaptive thermogenesis. IL-15 also promotes inflammation in adipose tissues that could sustain chronic inflammation leading to obesity-associated metabolic syndrome. | [
0.00711170444265008,
-0.00017629022477194667,
-0.021491359919309616,
0.017402589321136475,
0.00008233729749917984,
0.015969986096024513,
0.008694705553352833,
0.005158575251698494,
-0.008829088881611824,
-0.01520098652690649,
-0.010365232825279236,
0.008703188970685005,
-0.018293937668204308,
0.01639697514474392,
-0.04381366819143295,
-0.007024084217846394,
-0.014332063496112823,
0.008061351254582405,
0.007824843749403954,
-0.0029109944589436054,
0.0057618338614702225,
-0.023317689076066017,
0.00909717008471489,
0.027429329231381416,
0.03303389996290207,
0.013089808635413647,
-0.00259297713637352,
-0.01763739064335823,
-0.02796226367354393,
-0.005078754387795925,
-0.007692743092775345,
-0.032861653715372086,
-0.005842577666044235,
0.03953029587864876,
0.01525679137557745,
-0.014609909616410732,
-0.007150526158511639,
0.01501409336924553,
0.004893086850643158,
-0.003910398576408625,
-0.017560139298439026,
-0.010915316641330719,
0.014449373818933964,
0.023221425712108612,
-0.007559190504252911,
0.001864931546151638,
-0.0020069736056029797,
0.005968286655843258,
-0.001143894623965025,
0.004341830499470234,
-0.00702869426459074,
-0.014277050271630287,
-0.01652982272207737,
-0.004397509153932333,
-0.005751749500632286,
0.032946404069662094,
0.016332658007740974,
-0.02995801530778408,
-0.026657704263925552,
-0.01332817878574133,
0.0050604878924787045,
-0.014441031031310558,
-0.019514085724949837,
0.013352537527680397,
0.008495687507092953,
-0.06693325936794281,
0.0007112422026693821,
-0.01711202785372734,
0.006190383806824684,
-0.02024998515844345,
0.006753626745194197,
0.008460932411253452,
0.019407961517572403,
-0.018366023898124695,
-0.0010983925312757492,
-0.015173187479376793,
0.002441070508211851,
-0.013814203441143036,
0.02076888643205166,
0.008645713329315186,
0.003718635533004999,
-0.0011194448452442884,
0.020888440310955048,
0.022638749331235886,
0.01666899025440216,
0.014853576198220253,
-0.012968381866812706,
-0.0018219107296317816,
0.0074158902280032635,
0.00661360751837492,
0.0024561872705817223,
0.016741137951612473,
-0.009286545217037201,
0.014675497077405453,
-0.05788063630461693,
0.0026460494846105576,
0.0342569500207901,
0.007827356457710266,
0.003799560945481062,
0.009388657286763191,
-0.020249318331480026,
-0.005710164085030556,
0.012341463938355446,
0.007814930751919746,
-0.009448005817830563,
0.01297522522509098,
-0.01055182982236147,
0.00778881786391139,
-0.016186699271202087,
0.008333606645464897,
-0.0254618339240551,
0.0031903008930385113,
-0.004088061861693859,
0.013533679768443108,
0.0014730296097695827,
0.017912808805704117,
-0.01565638743340969,
-0.006228664889931679,
0.010737838223576546,
-0.0015344565035775304,
0.019451308995485306,
0.015852753072977066,
0.0020211730152368546,
0.017088351771235466,
-0.00032437779009342194,
-0.009523640386760235,
0.02903590351343155,
-0.009694678708910942,
-0.0010562418028712273,
-0.014414362609386444,
-0.008010247722268105,
0.011837422847747803,
0.003929705359041691,
0.009607076644897461,
0.0028011370450258255,
0.0005592453526332974,
-0.025284498929977417,
0.01219308190047741,
-0.019577540457248688,
-0.01027179230004549,
-0.007155826315283775,
0.003388377372175455,
0.009157577529549599,
0.008278857916593552,
0.03173864260315895,
0.018187178298830986,
-0.008616076782345772,
0.005627919919788837,
-0.0018860413692891598,
0.0030315497424453497,
0.009334420785307884,
0.0026657579001039267,
-0.012365870177745819,
-0.022220995277166367,
0.01262397039681673,
0.01941791921854019,
-0.019261421635746956,
0.03171524778008461,
-0.004575501196086407,
-0.011168603785336018,
-0.02885013446211815,
-0.0554548017680645,
0.03749930113554001,
0.008373054675757885,
0.010410891845822334,
-0.008423619903624058,
0.005449146032333374,
-0.02282482571899891,
0.012234453111886978,
0.008598212152719498,
-0.01511529553681612,
-0.00325481197796762,
-0.030982885509729385,
0.00947847031056881,
-0.0009226211113855243,
-0.014721894636750221,
0.004006141796708107,
0.008680377155542374,
-0.006508267018944025,
0.06666561216115952,
0.008321305736899376,
0.006755652837455273,
0.02914978191256523,
-0.013342664577066898,
-0.0146430479362607,
-0.03235074505209923,
0.010085572488605976,
-0.011827163398265839,
0.005640847142785788,
-0.005302822217345238,
-0.011117632500827312,
0.008648576214909554,
-0.03485598415136337,
-0.008728725835680962,
-0.06685982644557953,
0.003327049780637026,
0.010492278262972832,
0.011036592535674572,
0.013282470405101776,
-0.011836937628686428,
-0.0019795293919742107,
-0.018713289871811867,
0.021878782659769058,
0.009025607258081436,
0.01994936540722847,
0.00457752263173461,
0.04602091759443283,
-0.012960540130734444,
-0.017015988007187843,
-0.019120443612337112,
0.011848794296383858,
0.011907331645488739,
0.0002909192116931081,
-0.02346815913915634,
-0.004755243193358183,
-0.0012746753636747599,
-0.027378249913454056,
0.00746542401611805,
-0.0036075683310627937,
-0.013903186656534672,
0.0008278032764792442,
0.01457622554153204,
0.006398869678378105,
-0.003091956488788128,
-0.005322524346411228,
-0.027417048811912537,
0.017798125743865967,
0.009649032726883888,
0.0026852930895984173,
0.00469323992729187,
-0.026783853769302368,
0.0009507129434496164,
-0.01301555521786213,
0.007922874763607979,
0.020732734352350235,
-0.006448893342167139,
0.015814587473869324,
-0.016600970178842545,
0.019463755190372467,
-0.005520464852452278,
0.0031502521596848965,
0.008570777252316475,
0.019984543323516846,
-0.015250807628035545,
-0.005945165641605854,
-0.002830284647643566,
0.013345297425985336,
0.0009874256793409586,
-0.006252162624150515,
-0.0025264148134738207,
0.010921278968453407,
-0.03173524886369705,
-0.034873686730861664,
-0.03966621682047844,
-0.025922000408172607,
-0.023937568068504333,
-0.013315475545823574,
-0.01597512513399124,
0.021623175591230392,
-0.03212878853082657,
0.0025749742053449154,
0.007540460675954819,
-0.0068676951341331005,
0.04501837491989136,
-0.004487650468945503,
0.02135397493839264,
0.006226749625056982,
0.015204260125756264,
0.01933620125055313,
0.017212029546499252,
0.012688647024333477,
-0.0009518458973616362,
-0.012358784675598145,
-0.08058007061481476,
-0.01854996755719185,
-0.0011094536166638136,
-0.011234823614358902,
0.003044604090973735,
0.001305130310356617,
-0.0036849635653197765,
0.0015582935884594917,
-0.0034786227624863386,
-0.009136833250522614,
-0.007357810623943806,
-0.023195307701826096,
-0.00020775786833837628,
-0.0035558908712118864,
-0.01623435690999031,
-0.010282918810844421,
0.009342868812382221,
0.022231023758649826,
-0.004787750542163849,
0.007548375055193901,
0.0031751967035233974,
-0.03664237633347511,
-0.003927006386220455,
0.004956213757395744,
0.029109613969922066,
-0.04013419151306152,
0.0001988518051803112,
-0.00803582463413477,
-0.0017022774554789066,
0.00949106551706791,
-0.006967189256101847,
0.008600314147770405,
0.028091438114643097,
-0.028516478836536407,
-0.013101228512823582,
0.0115245021879673,
-0.00970017071813345,
0.015725260600447655,
-0.0015145489014685154,
-0.027697067707777023,
0.0015751372557133436,
0.006773283705115318,
0.032974086701869965,
-0.0009323873091489077,
0.006469124928116798,
0.009773362427949905,
0.004512161947786808,
0.029289277270436287,
0.013499735854566097,
0.000053693074733018875,
-0.00028856308199465275,
0.00034570274874567986,
-0.026783838868141174,
0.01874331757426262,
-0.007083545438945293,
-0.022969409823417664,
-0.0021723625250160694,
-0.001445455476641655,
-0.007321921177208424,
-0.012261481955647469,
0.001004828605800867,
-0.013970397412776947,
0.013623095117509365,
0.007632819470018148,
-0.0021890399511903524,
0.021059636026620865,
0.010651416145265102,
-0.004490056075155735,
-0.015574018470942974,
0.02078353613615036,
-0.034083783626556396,
0.01673354022204876,
-0.015826143324375153,
-0.022003937512636185,
-0.010552766732871532,
-0.008219395764172077,
-0.012158743105828762,
-0.005028912797570229,
0.023785244673490524,
-0.02277456969022751,
-0.01170460507273674,
0.01938682049512863,
0.005729065276682377,
-0.008525513112545013,
-0.0064444649033248425,
0.03352699056267738,
0.00602722680196166,
0.03360247239470482,
0.016304200515151024,
-0.011336338706314564,
0.01502719521522522,
0.030315861105918884,
0.007741598878055811,
0.015031332150101662,
0.017602067440748215,
0.006137510295957327,
-0.02141418308019638,
-0.019513655453920364,
0.008025062270462513,
0.007951962761580944,
0.010965781286358833,
-0.0007060215575620532,
-0.024415889754891396,
-0.007232558447867632,
-0.023313164710998535,
0.014729292131960392,
0.011317740194499493,
0.012923791073262691,
-0.02228899672627449,
0.0035421475768089294,
-0.013596337288618088,
0.012619610875844955,
-0.006971496623009443,
0.02510244958102703,
0.010092657059431076,
-0.01471797563135624,
-0.0023764509242028,
-0.003222779370844364,
0.07216378301382065,
0.0026086242869496346,
0.01030690036714077,
-0.028045501559972763,
0.05175749957561493,
-0.003746837144717574,
-0.010943497531116009,
-0.009659252129495144,
0.015417173504829407,
-0.003199450671672821,
0.010410943999886513,
-0.012162654660642147,
0.027085578069090843,
0.011032380163669586,
0.0030660480260849,
-0.0026152431964874268,
0.02315245382487774,
-0.03259279578924179,
0.010505640879273415,
-0.022003179416060448,
-0.011202673427760601,
-0.00948246754705906,
-0.007892085239291191,
-0.028404317796230316,
-0.007200052961707115,
-0.03138775750994682,
0.020054347813129425,
-0.015309501439332962,
-0.022209113463759422,
0.014617066830396652,
-0.0038350550457835197,
0.022356778383255005,
-0.007985346019268036,
0.007775688543915749,
-0.010620384477078915,
0.009105658158659935,
0.0249587781727314,
-0.023655742406845093,
0.002740308176726103,
-0.0027495757676661015,
-0.01909378357231617,
-0.0163821242749691,
0.028627529740333557,
0.003919140435755253,
-0.03273622691631317,
-0.03399091958999634,
-0.013292944058775902,
-0.012999460101127625,
-0.01672331430017948,
0.008095793426036835,
-0.0011529629118740559,
0.005407219752669334,
0.01582895591855049,
0.014937887899577618,
-0.0110488161444664,
-0.03417905420064926,
0.00623007956892252,
-0.006923294626176357,
-0.012149364687502384,
-0.015798294916749,
-0.017941348254680634,
-0.010405518114566803,
0.01752365753054619,
-0.016615089029073715,
-0.0007031059358268976,
-0.016646945849061012,
-0.01585957780480385,
0.005717886611819267,
-0.004654767923057079,
-0.014132729731500149,
0.009286503307521343,
0.027819976210594177,
0.0016092442674562335,
0.01964997500181198,
-0.04203658923506737,
0.021967990323901176,
0.005065754055976868,
0.01206223201006651,
0.01954806223511696,
0.0052075618878006935,
-0.03547714650630951,
-0.0030806148424744606,
0.011408239603042603,
-0.00658736377954483,
0.013068927451968193,
-0.00039318623021245003,
0.018128156661987305,
-0.07405801862478256,
-0.025279678404331207,
-0.001069225138053298,
-0.004443197511136532,
-0.01074952632188797,
0.015508638694882393,
-0.028128162026405334,
0.021713385358452797,
-0.013835743069648743,
-0.006393432151526213,
0.006787843536585569,
0.01054641604423523,
0.0007262381259351969,
0.0028550338465720415,
0.011627709493041039,
-0.02347434312105179,
-0.0033613929990679026,
0.005453471094369888,
-0.0042558396235108376,
-0.04041946679353714,
-0.035951629281044006,
0.005802749656140804,
-0.026240047067403793,
-0.0005016950890421867,
-0.0006742441328242421,
-0.08057849854230881,
-0.008417157456278801,
0.012861330062150955,
-0.03551023453474045,
0.028621383011341095,
-0.023584946990013123,
0.014805760234594345,
-0.0056201075203716755,
0.013478905893862247,
-0.015684030950069427,
0.01216053031384945,
0.014575185254216194,
0.016315443441271782,
-0.011561833322048187,
0.013956613838672638,
-0.010441371239721775,
0.00899256207048893,
0.005852248519659042,
0.02057144045829773,
0.003492829855531454,
0.011839781887829304,
0.015428579412400723,
-0.00874270498752594,
-0.009653324261307716,
-0.010821095667779446,
-0.022861557081341743,
-0.0012794630602002144,
0.015272486954927444,
0.0008660466410219669,
-0.009568793699145317,
-0.00910524558275938,
-0.013033335097134113,
-0.025163186714053154,
-0.024622764438390732,
-0.010025560855865479,
-0.012995006516575813,
0.011660434305667877,
-0.0012854044325649738,
0.017715152353048325,
-0.0036509083583950996,
-0.0038631234783679247,
-0.013248639181256294,
0.04109659045934677,
0.010322113521397114,
0.0005037197843194008,
-0.0277716014534235,
0.004708695691078901,
-0.011214305646717548,
0.013771623373031616,
-0.024957483634352684,
0.015993572771549225,
-0.013484087772667408,
-0.012163189239799976,
-0.01273278146982193,
-0.003455451689660549,
0.017167747020721436,
-0.008771716617047787,
0.044076867401599884,
-0.003224802203476429,
0.02473529800772667,
-0.002312558237463236,
0.019963886588811874,
-0.0010446971282362938,
0.07221715152263641,
-0.0019507049582898617,
0.0244523324072361,
-0.014170397073030472,
-0.0004731439985334873,
0.005244221072643995,
0.021566301584243774,
-0.02954675629734993,
-0.018775051459670067,
-0.016383763402700424,
-0.017102593556046486,
-0.020729398354887962,
-0.009913546033203602,
0.012232179753482342,
0.03543945401906967,
-0.004329705145210028,
0.005538455210626125,
-0.033708009868860245,
-0.06465933471918106,
0.034503474831581116,
0.00012010452337563038,
-0.0050882091745734215,
0.026183204725384712,
-0.004971695598214865,
-0.006337842904031277,
-0.013173891231417656,
0.028682904317975044,
0.006407600827515125,
0.007338924333453178,
0.015906432643532753,
0.01801636815071106,
-0.017700444906949997,
0.003726003924384713,
-0.003107777563855052,
0.022807985544204712,
0.014463726431131363,
-0.016179101541638374,
0.00870877131819725,
-0.027636468410491943,
0.04980650544166565,
0.030553335323929787,
0.007918941788375378,
0.004886024631559849,
-0.011602960526943207,
-0.010484328493475914,
0.021468885242938995,
0.023640871047973633,
-0.017575697973370552,
-0.003337092697620392,
-0.003998291213065386,
0.008732020854949951,
0.00013242545537650585,
0.0051934849470853806,
-0.004820019006729126,
-0.0117848115041852,
0.006903056055307388,
0.009813235141336918,
0.011277769692242146,
-0.018706824630498886,
-0.034047506749629974,
0.02693263441324234,
-0.022819029167294502,
0.060670457780361176,
-0.02071821317076683,
0.021387044340372086,
0.028060181066393852,
0.005221531726419926,
-0.015974195674061775,
-0.006560001987963915,
0.01711379550397396,
-0.026712968945503235,
0.00500775221735239,
0.016028286889195442,
0.007825817912817001,
0.021218329668045044,
0.020579788833856583,
0.04547132924199104,
-0.025896241888403893,
-0.011398231610655785,
0.019256573170423508,
-0.0014761536149308085,
0.04422669857740402,
-0.005894188303500414,
-0.007369722239673138,
-0.008568696677684784,
0.013964451849460602,
0.016826491802930832,
0.016868721693754196,
0.0059110140427947044,
0.011896850541234016,
-0.011299130506813526,
0.014378409832715988,
0.013592892326414585,
0.016373515129089355,
0.009564099833369255,
0.03261156007647514,
0.04226522892713547,
0.0002331287250854075,
-0.02790732868015766,
0.012076172977685928,
-0.018596870824694633,
-0.021259484812617302,
-0.002480287104845047,
-0.0035686453338712454,
-0.010955389589071274,
-0.004410572815686464,
-0.01833825558423996,
-0.034313470125198364,
-0.00986227672547102,
0.034919507801532745,
0.010580135509371758,
-0.0022726745810359716,
0.0010318197309970856,
0.030400574207305908,
0.012833567336201668,
0.02302967943251133,
-0.01020302064716816,
-0.03007432073354721,
-0.03308979421854019,
-0.01149800419807434,
0.0005202281754463911,
-0.006736660376191139,
-0.01899430900812149,
-0.013227139599621296,
-0.0215714443475008,
-0.03024628572165966,
-0.004986376501619816,
0.040437787771224976,
0.02189452201128006,
0.0170526672154665,
0.02887711487710476,
0.0032571651972830296,
-0.03110537678003311,
-0.014653090387582779,
0.006530354730784893,
0.003300088457763195,
0.008051322773098946,
-0.006370384246110916,
0.018587835133075714,
0.008926957845687866,
-0.006522001698613167,
0.005515404511243105,
0.002450989093631506,
-0.006677231751382351,
0.008301390334963799,
0.012595077976584435,
0.006499246694147587,
0.01331319846212864,
0.007498117163777351,
-0.003984684590250254,
0.010264413431286812,
0.01866767928004265,
-0.0015860742423683405,
-0.008550061844289303,
-0.012283148244023323,
0.018025383353233337,
0.014210816472768784,
-0.023407310247421265,
0.0098694683983922,
0.006189253646880388,
0.014170760288834572,
-0.04630894213914871,
0.029909228906035423,
-0.000042154453694820404,
0.022297514602541924,
-0.0030249105766415596,
0.0011954221408814192,
0.005693010054528713,
0.014635932631790638,
0.024320337921380997,
0.03663530945777893,
-0.024262510240077972,
-0.031592048704624176,
0.051427923142910004,
-0.007820974104106426,
-0.008142849430441856,
-0.01715182326734066,
0.019937794655561447,
0.02113575115799904,
-0.01388511061668396,
0.014383813366293907,
-0.006458062678575516,
0.03351893648505211,
-0.006901203654706478,
0.01605760119855404,
-0.023390773683786392,
-0.010821133852005005,
0.004389906767755747,
0.011167297139763832,
0.01413818821310997,
-0.011020481586456299,
-0.004934913013130426,
0.01877765916287899,
0.00043406314216554165,
0.014555996283888817,
-0.045139431953430176,
0.01024741493165493,
-0.03971284627914429,
0.010870145633816719,
-0.004561333917081356,
-0.009134897962212563,
0.013448375277221203
] | [
0.15279872715473175,
0.14162462949752808,
0.06273762136697769,
-0.08688271045684814,
-0.32563644647598267,
0.2763899266719818,
0.20276181399822235,
-0.40693920850753784,
-0.026396598666906357,
-0.25386348366737366,
0.09742423892021179,
0.8193861246109009,
-0.47022631764411926,
-0.6282892823219299,
-0.13064202666282654,
0.7761902809143066,
0.5008504390716553,
0.6859244108200073,
-0.42073217034339905,
-0.3130248486995697,
-0.15196004509925842,
-0.4339507520198822,
0.48063361644744873,
0.02839050069451332,
0.13416966795921326,
0.004130936227738857,
0.7075558304786682,
0.23967188596725464,
0.10340926051139832,
-0.25890594720840454,
-0.42409080266952515,
0.49075400829315186,
0.08197654038667679,
0.05988840013742447,
-0.10522031784057617,
0.5905959010124207,
-0.03275066614151001,
-0.0022330963984131813,
0.2118954211473465,
-0.013303466141223907,
-0.035852037370204926,
0.0913490504026413,
-0.7107571959495544,
0.560847818851471,
-0.24594898521900177,
-0.1450415700674057,
-1.4614593982696533,
0.5780553817749023,
-0.3870870769023895,
0.005738571751862764,
-0.2424764186143875,
0.42648980021476746,
0.24816662073135376,
0.2118058204650879,
0.2593529224395752,
0.5168824791908264,
-0.8441481590270996,
0.03415631875395775,
0.0811595767736435,
-0.41144537925720215,
0.20810121297836304,
-0.047536030411720276,
-0.08441051840782166,
0.3902192711830139,
-0.37582334876060486,
0.16234372556209564,
-0.2552286386489868,
-0.19462035596370697,
-0.33234667778015137,
-0.11375665664672852,
0.028552355244755745,
-0.23108282685279846,
-0.6130272746086121,
0.584001898765564,
-0.155460387468338,
-0.2612718939781189,
-0.1342480629682541,
-0.2712275981903076,
0.27470430731773376,
0.0653257966041565,
0.34331047534942627,
-0.15684764087200165,
0.38598302006721497,
0.18515507876873016,
0.015741365030407906,
0.4495067596435547,
0.1170031875371933,
0.6540697813034058,
0.04058089852333069,
-0.11582827568054199,
0.10801509767770767,
-0.08819092065095901,
0.16319599747657776,
0.299431174993515,
0.14091427624225616,
0.1672908216714859,
-0.17298033833503723,
0.02243698760867119,
-0.0970398336648941,
-0.013850514777004719,
0.1718498021364212,
0.03902037814259529,
-0.14867305755615234,
-0.14647622406482697,
-0.6848199367523193,
-0.2808457016944885,
0.06917068362236023,
-0.8789386749267578,
-0.16752506792545319,
0.20856857299804688,
-1.029589295387268,
0.1878013163805008,
-0.4992215931415558,
-0.46303993463516235,
0.004394549410790205,
-0.10038065165281296,
0.10904759913682938,
-0.1747998297214508,
-0.35806575417518616,
0.4476679861545563,
-0.5123865604400635,
1.0354664325714111,
-0.039997268468141556,
0.09905336797237396,
0.0959809198975563,
-0.09318526834249496,
0.15725351870059967,
0.2559278905391693,
0.24427509307861328,
0.5556693077087402,
0.4475429952144623,
0.3632412254810333,
-0.5348084568977356,
0.025693828240036964,
-0.05322886258363724,
-0.2845998704433441,
0.48625481128692627,
-0.14721441268920898,
0.16522645950317383,
0.12032653391361237,
-0.6231769323348999,
-0.7489200234413147,
-0.16661682724952698,
-0.15531133115291595,
-0.06629228591918945,
-0.6320501565933228,
-0.09951452910900116,
0.03885140269994736,
0.15179364383220673,
-0.2146240919828415,
0.23456092178821564,
-0.27926385402679443,
-0.35025307536125183,
-0.3328467309474945,
0.2617301940917969,
0.40696099400520325,
-0.11383047699928284,
-0.32524794340133667,
-0.34162530303001404,
0.17297950387001038,
0.338855117559433,
0.12063585966825485,
-0.6989114880561829,
-0.29077357053756714,
0.7321845293045044,
-0.09596596658229828,
0.24081645905971527,
0.16468633711338043,
0.2949305772781372,
-0.10252314805984497,
-0.43439462780952454,
-0.5958983898162842,
0.19986487925052643,
-0.3229026794433594,
-0.38828492164611816,
0.11574975401163101,
0.18096931278705597,
-0.017998039722442627,
0.12617796659469604,
-0.21068894863128662,
-0.8528477549552917,
-0.3029055595397949,
0.18644922971725464,
-0.1620478332042694,
0.748640775680542,
-0.15410563349723816,
0.6053237318992615,
-0.2555334270000458,
-0.4076968729496002,
0.14314213395118713,
-0.0834387019276619,
-0.28276699781417847,
1.0070077180862427,
-0.5207568407058716,
1.4176499843597412,
-0.4817025363445282,
-0.7067422270774841,
1.0471959114074707,
-0.11291463673114777,
0.0840056762099266,
-0.2831026017665863,
-0.3438968062400818,
0.552920401096344,
-0.3271876275539398,
-0.5057954788208008,
-0.022931749001145363,
-0.26387491822242737,
-0.05304122716188431,
-0.35513991117477417,
0.7334718108177185,
0.285175621509552,
-0.45682352781295776,
-0.1532849371433258,
-0.09053061157464981,
-0.03094404563307762,
-0.14276142418384552,
-0.11001704633235931,
0.19869649410247803,
-0.35331448912620544,
-0.01173053402453661,
0.13321687281131744,
-0.16957248747348785,
0.1660531908273697,
0.6918942928314209,
-0.11835244297981262,
0.5986902117729187,
0.7698275446891785,
0.2915743291378021,
0.5352929830551147,
-0.557213306427002,
0.07099060714244843,
-0.13861331343650818,
0.2966592013835907,
-0.0437006950378418,
-0.0646815374493599,
0.04099547490477562,
0.42565032839775085,
-0.5681337714195251,
0.3929018974304199,
-0.41308704018592834,
-0.11868589371442795,
0.2986811101436615,
-0.3099559545516968,
-0.30072593688964844,
-0.023620175197720528,
-0.12767985463142395,
-0.10720334202051163,
1.0505943298339844,
-1.0986131429672241,
-0.3424358069896698,
0.1731838434934616,
0.25543802976608276,
0.1857476532459259,
-0.26758188009262085,
-0.18889175355434418,
-0.23446804285049438,
0.09207490086555481,
-0.631287157535553,
0.4648340344429016,
-0.19413445889949799,
-0.037835508584976196,
-0.015318606048822403,
0.023327350616455078,
0.06290104985237122,
0.3593190014362335,
-0.5648522973060608,
-0.6703423857688904,
-0.5402809977531433,
0.7072852253913879,
0.6459895968437195,
0.9841939806938171,
0.18363048136234283,
-0.9698752760887146,
0.10953743755817413,
0.04000081494450569,
-0.1866404414176941,
0.11968280375003815,
0.7635219693183899,
-0.766754150390625,
-0.16465730965137482,
0.09287060797214508,
0.4817907512187958,
0.824737012386322,
0.5320389270782471,
-0.35486480593681335,
-0.19145984947681427,
-0.302016019821167,
-0.6863882541656494,
-0.7980753779411316,
-0.2883797883987427,
-0.153935506939888,
0.663623034954071,
-0.133896604180336,
-0.7126255631446838,
0.39886417984962463,
0.4249951243400574,
-0.19057059288024902,
0.3473070561885834,
0.7432194352149963,
-0.2591938078403473,
0.4010631740093231,
0.3274078667163849,
0.3250459134578705,
-0.25557374954223633,
-0.2009282261133194,
-0.054353341460227966,
-0.22604309022426605,
-0.01797952502965927,
-5.8804850578308105,
0.29590675234794617,
-0.30586278438568115,
-0.264864057302475,
-0.5819640159606934,
-0.15611685812473297,
0.6387485861778259,
0.14074642956256866,
0.09413844347000122,
0.1336829513311386,
0.030355049297213554,
0.09510280936956406,
0.0980602577328682,
0.12200400233268738,
0.0193634070456028,
0.27880924940109253,
0.6554815769195557,
-0.5024726986885071,
0.5983901023864746,
0.4142737090587616,
0.2507484257221222,
-0.4185817241668701,
-0.0888419896364212,
0.7843157052993774,
0.0069151162169873714,
0.07773450762033463,
-0.5283418297767639,
0.19503487646579742,
0.12841318547725677,
-0.30768781900405884,
0.20738790929317474,
-0.36486801505088806,
0.17345571517944336,
-0.07084577530622482,
0.8368484377861023,
0.08594826608896255,
0.046376075595617294,
0.10812133550643921,
-0.07982371002435684,
-0.48421958088874817,
0.14323487877845764,
0.12810155749320984,
-0.1509375274181366,
-0.29283812642097473,
0.4991791248321533,
-0.07725311070680618,
-0.3456762135028839,
-0.014577596448361874,
-0.2663179337978363,
0.03620776906609535,
0.2425665706396103,
-0.1823187619447708,
-0.5040977001190186,
0.4450230598449707,
0.4048992991447449,
0.33575618267059326,
0.1529236137866974,
0.26767614483833313,
-0.5464584231376648,
0.2352195382118225,
-0.29639482498168945,
-0.27150097489356995,
-0.5584905743598938,
-0.4337364733219147,
-0.18123672902584076,
0.8278418779373169,
-0.1686091274023056,
-0.6442531943321228,
0.11171618849039078,
0.13062307238578796,
-0.3348235785961151,
0.5636651515960693,
0.22402158379554749,
-0.7418694496154785,
0.19627144932746887,
-0.07994215190410614,
0.1835205852985382,
0.445834755897522,
0.013467040844261646,
-0.0628134161233902,
-0.5754615068435669,
-0.6707175374031067,
-0.01848849654197693,
0.05418410524725914,
-0.044084347784519196,
-0.16022014617919922,
0.1642560362815857,
0.49677592515945435,
0.07892058044672012,
0.442013144493103,
0.8111152052879333,
-0.40259456634521484,
-0.09169682115316391,
0.7774901986122131,
0.09443830698728561,
0.008826974779367447,
0.31605127453804016,
0.22907719016075134,
0.6788423657417297,
-0.013065827079117298,
0.14359448850154877,
0.2948444187641144,
-0.05323350057005882,
-0.9844021201133728,
0.14157019555568695,
0.1585959792137146,
-0.6957661509513855,
0.1640411913394928,
0.8273569345474243,
-0.9291582703590393,
-0.04774339497089386,
0.04897883161902428,
-0.3171018064022064,
-0.16652193665504456,
0.7408517003059387,
-0.4089663624763489,
0.29295608401298523,
-0.11867894232273102,
0.41995149850845337,
-0.36514678597450256,
-0.31820017099380493,
0.22737978398799896,
-0.6579146385192871,
-0.2079673707485199,
-0.4857604503631592,
-0.18007269501686096,
0.21889536082744598,
0.7474659085273743,
-0.7514998912811279,
0.3426433801651001,
0.39557966589927673,
0.6920409202575684,
0.029479263350367546,
0.2554842531681061,
-0.001629152800887823,
-0.2818862199783325,
-0.03697942942380905,
0.18758639693260193,
0.4897083342075348,
-0.27641046047210693,
0.425750195980072,
0.1317070722579956,
-0.06075118109583855,
-0.18482260406017303,
0.3182453215122223,
0.07462509721517563,
-0.20398294925689697,
-0.19826626777648926,
-0.5605599880218506,
-0.17555119097232819,
0.5164627432823181,
0.05351635813713074,
-0.3776063919067383,
0.41048723459243774,
-0.06924004852771759,
0.36623361706733704,
0.3377073407173157,
-0.06644236296415329,
0.050283197313547134,
-0.8418875336647034,
0.34632202982902527,
0.18277093768119812,
-1.0424084663391113,
-0.2952865660190582,
-0.21275447309017181,
-0.39543071389198303,
0.022841865196824074,
-0.6978951692581177,
0.331487238407135,
0.25010278820991516,
0.07715911418199539,
-0.30909112095832825,
0.1295720338821411,
-0.04470670968294144,
-0.10908379405736923,
-0.36048752069473267,
-0.5163027048110962,
-0.021293429657816887,
-0.06867703795433044,
0.3338726758956909,
0.11285741627216339,
-0.6418898701667786,
0.007027710787951946,
-0.24945186078548431,
0.3638492822647095,
0.15342217683792114,
0.08419878780841827,
0.0815691277384758,
-0.11664804816246033,
-0.47193458676338196,
0.2850005626678467,
0.0821981132030487,
0.2466619461774826,
0.0358535535633564,
0.27053743600845337,
0.2101110965013504,
0.5400453209877014,
0.5892966985702515,
0.028848037123680115,
0.12094373255968094,
-0.09151796251535416,
0.45228904485702515,
-0.09770230948925018,
0.15564066171646118,
0.18330997228622437,
0.028708763420581818,
-0.6974498629570007,
0.42486056685447693,
-0.2892177999019623,
-0.30248215794563293,
-0.5019673109054565,
-0.5921316742897034,
-0.21717895567417145,
-0.09245318919420242,
-0.09753693640232086,
0.3997584879398346,
0.06723164021968842,
0.010160358622670174,
-0.2509844899177551,
0.35556307435035706,
0.15678679943084717,
0.2206864058971405,
-0.6627499461174011,
0.08165475726127625,
-0.1386483758687973,
-0.20534831285476685,
0.8603388667106628,
-0.6032484173774719,
0.3422660827636719,
0.29640790820121765,
0.03922267630696297,
0.35806822776794434,
0.2717234790325165,
0.41446614265441895,
-0.0005303857033140957,
-0.45562949776649475,
-0.30388909578323364,
0.48990246653556824,
0.16839513182640076,
0.3100009560585022,
0.10068713873624802,
0.8014944195747375,
-0.28433504700660706,
0.4488697350025177,
0.49728208780288696,
0.7297957539558411,
-0.06831331551074982,
-0.7186525464057922,
-0.5212999582290649,
0.35409727692604065,
0.3110194206237793,
0.10692562162876129,
0.1690887063741684,
0.3513163924217224,
0.11220439523458481,
-0.41546741127967834,
0.2696703374385834,
-0.0406942181289196,
-0.34238165616989136,
0.24594634771347046,
-0.06153864040970802,
0.2933451235294342,
-0.1485954076051712,
0.09334343671798706,
-0.02893931046128273,
0.3825934827327728,
0.1937778741121292,
-0.7366673946380615,
0.5333078503608704,
0.11562581360340118,
0.22490186989307404,
-0.1247713565826416,
0.30362656712532043,
0.7032610177993774,
0.028122015297412872,
0.017676567658782005,
-0.6263546943664551,
0.06256889551877975,
-0.05526890233159065,
-0.008419501595199108,
-0.14251860976219177,
-0.45929035544395447,
0.7240049242973328,
-0.5820205211639404,
0.05476435646414757,
-0.7389827966690063,
0.037938665598630905,
0.14165541529655457,
-0.5682809352874756,
-0.019086021929979324,
-0.13542620837688446,
0.08699320256710052,
-0.6716738343238831,
-1.161977767944336,
-0.36381468176841736,
0.4118369519710541,
0.010542319156229496,
0.26581254601478577,
-0.1620052456855774,
-0.2408769726753235,
-0.4752875566482544,
0.5754314661026001,
0.36307159066200256,
-0.20834164321422577,
-0.6785969138145447,
0.09645453095436096,
0.2403285801410675,
-0.29521942138671875,
-0.4896377921104431,
-0.17270353436470032,
-0.10441354662179947,
-0.16347470879554749,
0.42019122838974,
0.16661518812179565,
-0.3942487835884094,
0.14929711818695068,
-0.3525228798389435,
0.0632372498512268,
0.15466240048408508,
0.4782238304615021,
-0.0973781943321228,
0.4439751207828522,
0.43012136220932007,
0.11795914173126221,
-0.4958423674106598,
0.2674823999404907,
-0.05358234792947769,
0.5460271239280701,
0.12892720103263855,
0.5985499024391174,
0.22652612626552582,
0.21388038992881775,
-0.07550879567861557,
0.8996956944465637,
0.44654136896133423,
0.15720176696777344,
0.39427298307418823,
-0.7090625762939453,
-0.06921335309743881,
-0.18389175832271576,
0.9829332828521729,
0.4917641580104828,
-0.06954137235879898,
-0.18812455236911774,
0.14465326070785522,
0.21029527485370636,
-0.35197052359580994,
0.01800983026623726,
-0.04071228578686714,
0.3329589068889618,
0.2833308279514313,
-0.23866857588291168,
-0.5609439015388489,
0.13119548559188843,
-0.49095532298088074,
0.1629370003938675,
0.3150266110897064,
-0.41338396072387695,
-1.0786888599395752,
0.5315293073654175,
-0.3702680170536041,
0.030355464667081833,
0.03485943377017975,
0.2182873785495758,
-0.22041264176368713,
0.15166224539279938,
0.5540000200271606,
0.021032162010669708,
0.279161661863327,
0.3872091472148895,
-0.5803436636924744,
0.15465208888053894,
0.061294350773096085,
-0.11483606696128845,
0.20872744917869568,
-0.3002817928791046,
0.13700060546398163,
-0.10696466267108917,
0.3244737982749939,
0.38889867067337036,
-0.34811168909072876,
0.20912712812423706,
-0.2670343518257141,
-0.7626848816871643,
-0.5421355962753296,
-0.1303415447473526,
-0.39656659960746765,
-0.30723491311073303,
0.1137392669916153,
-0.43439188599586487,
0.15808016061782837,
-0.2093106210231781,
0.0377073734998703,
0.3942457437515259,
-0.10472487658262253,
-0.237229123711586,
-0.25878089666366577,
0.31821346282958984,
0.31274205446243286,
0.04494289308786392,
-0.12923026084899902,
0.14922872185707092,
-0.1996375173330307,
0.22618438303470612,
-0.30760785937309265,
0.3735729157924652,
-0.42762792110443115,
-0.4265916645526886,
-0.6305682063102722,
-0.23839066922664642,
0.7778679132461548,
0.28909674286842346,
-0.20441757142543793,
0.20293749868869781,
0.5498132705688477,
0.47724467515945435,
0.019652673974633217,
-0.7498893737792969,
-0.4421580135822296,
-0.25344035029411316,
-0.12838955223560333,
-0.20874916017055511,
0.4284078776836395,
0.06232214346528053,
-0.1645999550819397,
0.02866998128592968,
0.2957330048084259,
-0.15558068454265594,
0.11737074702978134,
-0.17602503299713135,
-0.6882257461547852,
-0.004929357673972845,
-0.3465231657028198,
0.06964901089668274,
-0.7975033521652222,
0.28730088472366333,
0.2577466666698456,
0.1845458745956421,
0.13565494120121002,
-0.2605465054512024,
-0.01143625471740961,
-0.23134933412075043,
-0.017034001648426056,
-0.18605968356132507,
0.4412570595741272,
0.08672117441892624,
-0.008457996882498264,
-0.7163477540016174,
-0.39027300477027893,
0.6201764345169067,
-0.10947995632886887,
-0.24933354556560516,
0.0004782592586707324,
-0.0032460226211696863,
0.04002037271857262,
-0.07272227853536606,
0.417007178068161,
-0.6095789670944214,
-0.42016905546188354,
-0.11072773486375809
] |
Epigenetic genome modifications are thought to be important for specifying the lineage and developmental stage of cells within a multicellular organism. Here, we show that the epigenetic profile of pluripotent embryonic stem cells (ES) is distinct from that of embryonic carcinoma cells, haematopoietic stem cells (HSC) and their differentiated progeny. Silent, lineage-specific genes replicated earlier in pluripotent cells than in tissue-specific stem cells or differentiated cells and had unexpectedly high levels of acetylated H3K9 and methylated H3K4. Unusually, in ES cells these markers of open chromatin were also combined with H3K27 trimethylation at some non-expressed genes. Thus, pluripotency of ES cells is characterized by a specific epigenetic profile where lineage-specific genes may be accessible but, if so, carry repressive H3K27 trimethylation modifications. H3K27 methylation is functionally important for preventing expression of these genes in ES cells as premature expression occurs in embryonic ectoderm development (Eed)-deficient ES cells. Our data suggest that lineage-specific genes are primed for expression in ES cells but are held in check by opposing chromatin modifications. | [
0.006478607654571533,
0.01182325929403305,
-0.00603835005313158,
0.020661592483520508,
-0.015189610421657562,
0.012125289067626,
0.012903351336717606,
-0.006561932619661093,
-0.013296188786625862,
-0.022701330482959747,
0.008677400648593903,
0.01226012036204338,
-0.008025011979043484,
-0.004198702983558178,
0.02999892458319664,
0.01174046378582716,
-0.0008704559877514839,
0.007341783959418535,
0.007104850374162197,
-0.022596435621380806,
0.017564166337251663,
0.008671446703374386,
0.010641021654009819,
-0.02113189920783043,
0.006796947680413723,
0.026338709518313408,
0.014665644615888596,
-0.009752482175827026,
-0.011124261654913425,
-0.029390772804617882,
0.03582887724041939,
-0.034969262778759,
0.011857149191200733,
-0.015960000455379486,
-0.004976351745426655,
0.005275328643620014,
-0.000979496631771326,
0.028236210346221924,
0.023771755397319794,
-0.0049228970892727375,
0.011885363608598709,
-0.008263942785561085,
0.0063645862974226475,
0.0070964861661195755,
-0.009231729432940483,
0.020683787763118744,
-0.0032897447235882282,
-0.0024206130765378475,
0.0013384297490119934,
0.005732768215239048,
-0.02260425314307213,
-0.004808501340448856,
-0.01513726357370615,
0.012979989871382713,
-0.007349948398768902,
-0.006627349182963371,
0.019989946857094765,
0.013803765177726746,
0.010678596794605255,
-0.0026505112182348967,
0.022424837574362755,
-0.023249875754117966,
0.006867055781185627,
0.00964393001049757,
-0.036103665828704834,
-0.06637246161699295,
-0.00458441162481904,
0.00036970782093703747,
-0.0057554845698177814,
-0.01582220010459423,
-0.0001393333077430725,
0.0045276302844285965,
0.0036104777827858925,
-0.0000293022021651268,
0.005837847478687763,
-0.0019972219597548246,
-0.03004816547036171,
0.026141706854104996,
0.021374190226197243,
0.0026890027802437544,
0.016308490186929703,
-0.01318289339542389,
0.012387478724122047,
-0.0009615229209885001,
-0.016397742554545403,
0.005339009687304497,
-0.014508502557873726,
0.016384856775403023,
0.023887358605861664,
-0.06295223534107208,
0.0056826649233698845,
0.019672732800245285,
-0.004288093652576208,
-0.01193729043006897,
-0.05043788254261017,
0.010632445104420185,
-0.03157470002770424,
-0.011958979070186615,
-0.035593271255493164,
0.0033108892384916544,
-0.016766633838415146,
0.019586119800806046,
0.017943035811185837,
0.00637858547270298,
0.0003574024885892868,
0.014487920328974724,
-0.016768379136919975,
0.030781308189034462,
0.05126890912652016,
0.010065575130283833,
0.000696968287229538,
-0.021596143022179604,
0.009405207820236683,
0.024053871631622314,
-0.009139375761151314,
-0.003656598972156644,
-0.008076077327132225,
0.02478044107556343,
0.017310205847024918,
-0.0004252549260854721,
0.01065979152917862,
0.011673497036099434,
-0.0023520649410784245,
0.01428358443081379,
0.004853782244026661,
-0.03805748373270035,
-0.05771300941705704,
-0.007740325294435024,
-0.0038667935878038406,
-0.010933052748441696,
-0.009841615334153175,
0.015084024518728256,
0.021303940564393997,
0.0020431820303201675,
0.0037820981815457344,
-0.0002477038651704788,
-0.02667054533958435,
-0.015258842147886753,
-0.007767036557197571,
-0.022904422134160995,
-0.005826685577630997,
0.007219763472676277,
0.003114580875262618,
0.010164876468479633,
0.010025577619671822,
-0.002268003299832344,
0.012289399281144142,
-0.008380700834095478,
0.0037649651058018208,
-0.055864252150058746,
-0.0013827818911522627,
-0.01767602190375328,
-0.003436948172748089,
-0.0034679370000958443,
0.024882370606064796,
0.019362695515155792,
-0.026692770421504974,
0.005158046260476112,
0.00813375785946846,
0.030207378789782524,
-0.007610366214066744,
-0.024521969258785248,
0.013573511503636837,
0.011110631749033928,
0.0393529012799263,
0.0016352217644453049,
-0.018085818737745285,
-0.009136905893683434,
-0.007543608546257019,
0.005891676992177963,
-0.008760365657508373,
0.0006662635132670403,
0.019327599555253983,
0.012059168890118599,
0.023977089673280716,
-0.01320660300552845,
-0.0004726368933916092,
0.008734081871807575,
-0.02099069207906723,
0.0661783367395401,
-0.004593478515744209,
-0.0009016965050250292,
-0.029973238706588745,
0.022552158683538437,
0.011773558333516121,
0.003941861912608147,
-0.004773309454321861,
0.0009398293914273381,
0.011229281313717365,
-0.0012020210269838572,
0.008888843469321728,
0.0034210130106657743,
-0.02780783735215664,
0.018884483724832535,
-0.02725318819284439,
0.0023651684168726206,
-0.012333761900663376,
0.007586868479847908,
-0.039241399616003036,
-0.01385992206633091,
0.027667146176099777,
-0.01791038177907467,
0.010961889289319515,
0.02575119584798813,
0.0020066173747181892,
0.02632811665534973,
-0.024211525917053223,
-0.007784991525113583,
-0.02847076766192913,
0.023249655961990356,
0.019449323415756226,
-0.05357149988412857,
-0.0008799626957625151,
-0.0005738270119763911,
-0.005691349506378174,
0.016986452043056488,
0.023541033267974854,
0.002121160738170147,
0.0026789510156959295,
-0.016281841322779655,
0.0026122296694666147,
-0.00597080122679472,
0.04736483097076416,
0.002264577429741621,
0.013249663636088371,
-0.038920074701309204,
0.008155818097293377,
0.01066657342016697,
-0.006850827019661665,
-0.011813352815806866,
-0.011682641692459583,
-0.0358973853290081,
-0.015362870879471302,
-0.006069340277463198,
-0.005214286502450705,
0.029261313378810883,
0.01160651445388794,
0.0007108962163329124,
0.01190072949975729,
-0.004121705424040556,
-0.022404350340366364,
0.014478538185358047,
0.01000591553747654,
-0.013180013746023178,
0.0028390614315867424,
0.04814613237977028,
0.005479712970554829,
0.017482630908489227,
0.013754639774560928,
-0.017610445618629456,
0.00808768067508936,
0.023574380204081535,
0.00844879075884819,
0.009162774309515953,
0.0053938874043524265,
-0.015476454049348831,
-0.023577988147735596,
0.0226517915725708,
0.026886459439992905,
-0.01599850505590439,
-0.0027632624842226505,
0.010170483961701393,
0.004710248205810785,
-0.008422760292887688,
-0.01765366643667221,
-0.00991898775100708,
0.017015790566802025,
0.030675705522298813,
0.026206303387880325,
-0.013791307806968689,
0.012171168811619282,
-0.00595850870013237,
0.008109549060463905,
-0.08124792575836182,
-0.008289603516459465,
0.012145786546170712,
0.004054342396557331,
0.005145471543073654,
-0.009296047501266003,
0.018346719443798065,
-0.000348818430211395,
-0.005804381798952818,
0.018453970551490784,
0.009030268527567387,
-0.022133124992251396,
-0.017524877563118935,
-0.0029069092124700546,
-0.008653662167489529,
-0.004531990736722946,
0.005800403654575348,
0.0006170832784846425,
-0.013821383006870747,
-0.025949664413928986,
-0.022880645468831062,
-0.025871168822050095,
0.0035038492642343044,
0.020929552614688873,
-0.022902462631464005,
0.016631996259093285,
0.003982676193118095,
0.0108041912317276,
-0.006415042094886303,
0.0013785199262201786,
-0.038613222539424896,
-0.011796446517109871,
0.034131404012441635,
0.01074296422302723,
-0.016381416469812393,
-0.0051405904814600945,
0.019589059054851532,
-0.020378844812512398,
-0.004553251899778843,
0.06551553308963776,
-0.019665643572807312,
0.01976095139980316,
-0.0011395197361707687,
-0.005562793929129839,
0.0042098043486475945,
0.006895049475133419,
0.029305221512913704,
-0.010069786570966244,
0.018045369535684586,
0.0011327937245368958,
0.005313632544130087,
0.005453724414110184,
0.00460448395460844,
0.0212349072098732,
-0.016907669603824615,
0.0032468747813254595,
-0.005153535399585962,
0.019965382292866707,
-0.012594420462846756,
-0.008901156485080719,
0.027098216116428375,
0.021240130066871643,
-0.029025118798017502,
-0.021119482815265656,
0.0036851689219474792,
0.019393987953662872,
0.016226885840296745,
0.0046751415356993675,
-0.009842421859502792,
0.0021312914323061705,
0.02005651220679283,
-0.013978485018014908,
-0.0032098691444844007,
-0.0055116815492510796,
0.0053549231961369514,
-0.002805638127028942,
-0.01019180566072464,
-0.011272420175373554,
0.02491636760532856,
-0.016908034682273865,
-0.027658764272928238,
-0.01724260300397873,
-0.012203813530504704,
-0.013525690883398056,
-0.024340899661183357,
-0.02465883269906044,
-0.0028414626140147448,
0.04172525554895401,
0.010649904608726501,
-0.018724054098129272,
-0.016608932986855507,
0.0013836692087352276,
0.022045910358428955,
0.012059707194566727,
-0.01932498812675476,
-0.024098066613078117,
0.019103921949863434,
-0.008896281011402607,
0.0167700108140707,
0.009320072829723358,
-0.0029603177681565285,
0.0032808242831379175,
0.01797247678041458,
-0.009633727371692657,
-0.03975639492273331,
0.014796677976846695,
-0.009524162858724594,
0.01456732489168644,
0.014249213971197605,
0.0008260151371359825,
0.0067780171521008015,
-0.008727576583623886,
-0.003971552941948175,
0.0037097553722560406,
0.019331704825162888,
0.011878658086061478,
0.0054485187865793705,
-0.0021584422793239355,
0.07162202149629593,
0.005955201108008623,
-0.0009352562483400106,
-0.03318621590733528,
0.009595420211553574,
-0.020157096907496452,
-0.014263926073908806,
0.009834405966103077,
-0.019656602293252945,
0.0063123805448412895,
0.014921797439455986,
0.003962306771427393,
0.012502774596214294,
0.02554360404610634,
-0.03302226960659027,
-0.018048802390694618,
-0.02095644734799862,
0.015364134684205055,
-0.015606442466378212,
-0.00480827409774065,
0.008069050498306751,
-0.034784477204084396,
-0.00790298730134964,
0.00937296450138092,
-0.0002566250041127205,
0.015874965116381645,
0.01232452318072319,
-0.010435258038341999,
-0.017003241926431656,
0.00804732833057642,
0.0038947071880102158,
-0.028339898213744164,
-0.007023881189525127,
-0.001799616846255958,
0.04930170625448227,
0.026554003357887268,
0.031394537538290024,
-0.011262362822890282,
-0.014003617689013481,
0.00166683632414788,
0.004980405792593956,
-0.008123903535306454,
0.029360422864556313,
0.006502964533865452,
0.0010137762874364853,
0.011694196611642838,
0.027949385344982147,
-0.009329033084213734,
0.00037840777076780796,
-0.0240461565554142,
-0.022338194772601128,
0.00328310439363122,
0.018215619027614594,
0.006295503582805395,
0.011857744306325912,
0.0017224382609128952,
0.010063569992780685,
-0.0026077297516167164,
0.004656417760998011,
0.010156235657632351,
-0.03779420256614685,
-0.04016336798667908,
-0.007089061662554741,
-0.0189809650182724,
0.00950799509882927,
-0.019079312682151794,
-0.021022282540798187,
-0.01545869279652834,
-0.0037516397424042225,
0.004283694084733725,
0.004993724636733532,
0.004871479235589504,
-0.0233946293592453,
0.0009986076038330793,
0.012487964704632759,
0.0221303328871727,
0.01656300574541092,
-0.03570394963026047,
0.017615608870983124,
0.010261889547109604,
-0.010114085860550404,
0.03345036879181862,
-0.015080111101269722,
-0.010374045930802822,
0.009133626706898212,
-0.027012508362531662,
0.0015411796048283577,
-0.07463496923446655,
-0.02866370603442192,
0.007814978249371052,
-0.007022101432085037,
-0.008308128453791142,
-0.0026037851348519325,
-0.025889426469802856,
0.03331008180975914,
0.01547044888138771,
0.0005980836576782167,
0.018119290471076965,
-0.01802869513630867,
-0.002903633750975132,
0.0051153493113815784,
0.011717606335878372,
0.022513089701533318,
0.011039775796234608,
-0.002019637729972601,
0.007689976133406162,
-0.012218551710247993,
0.04247727617621422,
-0.024292346090078354,
-0.048549436032772064,
-0.0097303232178092,
-0.006928800605237484,
-0.08069214224815369,
0.027926325798034668,
-0.02293219417333603,
-0.010561585426330566,
-0.02545766904950142,
-0.0007244390435516834,
-0.0030454089865088463,
0.010449891909956932,
-0.021903634071350098,
-0.01636817678809166,
0.013459580950438976,
0.010246746242046356,
0.012569757178425789,
-0.026515081524848938,
-0.008414411917328835,
-0.008036554791033268,
0.02558715082705021,
-0.030179983004927635,
0.003078623441979289,
0.03464658185839653,
-0.02123984694480896,
-0.010139278136193752,
-0.010960480198264122,
-0.023404402658343315,
-0.008209881372749805,
-0.03523338586091995,
-0.021290963515639305,
0.012149190530180931,
0.012056858278810978,
0.01072622649371624,
-0.019900228828191757,
-0.01584334298968315,
-0.003863789141178131,
0.004463596735149622,
0.003080198308452964,
-0.024511685594916344,
0.01437881588935852,
-0.02167530730366707,
0.00048117758706212044,
0.01002526469528675,
-0.004383476451039314,
0.016375267878174782,
0.004453790374100208,
0.024172350764274597,
-0.006999590899795294,
-0.015190713107585907,
0.0058077070862054825,
-0.013012005016207695,
-0.00959327444434166,
0.02515377849340439,
0.005789559334516525,
-0.0012263813987374306,
0.008458221331238747,
0.005559433717280626,
-0.017777876928448677,
0.023594822734594345,
0.006390802562236786,
0.01102820411324501,
0.02607908844947815,
-0.00757970754057169,
-0.004438497591763735,
0.0017721051117405295,
-0.01087171584367752,
0.0709211528301239,
-0.016181662678718567,
0.004873118828982115,
-0.0417795404791832,
-0.009930869564414024,
0.005313313100486994,
-0.03277933597564697,
-0.021990884095430374,
-0.032779909670352936,
-0.006394002586603165,
0.005123899318277836,
0.012823089957237244,
0.0057827928103506565,
0.011653922498226166,
-0.0034643574617803097,
-0.008790800347924232,
0.005006862338632345,
0.007446233183145523,
0.015131290070712566,
0.01733449660241604,
-0.006763890851289034,
-0.0025181893724948168,
-0.01218415703624487,
-0.03564798831939697,
0.007761173881590366,
0.004809139762073755,
-0.020177504047751427,
0.007609709165990353,
-0.0017352012218907475,
-0.0030909916386008263,
0.002210500417277217,
0.0016181860119104385,
-0.0002101255813613534,
-0.025844167917966843,
0.02394034154713154,
0.004042666871100664,
-0.023963626474142075,
0.00770573690533638,
-0.00994768925011158,
-0.01231202483177185,
0.009648334234952927,
0.011452915146946907,
-0.006191113963723183,
-0.035289157181978226,
0.011118298396468163,
0.007159952074289322,
-0.0034565688110888004,
0.0076911780051887035,
-0.02078825980424881,
0.016200833022594452,
0.02505195140838623,
0.004422193858772516,
0.02683068811893463,
0.003196329576894641,
0.0027200812473893166,
0.026108108460903168,
0.007694157771766186,
0.02187403291463852,
0.022565146908164024,
-0.013940452598035336,
0.028702961280941963,
-0.011423112824559212,
0.0077200825326144695,
-0.013635743409395218,
-0.009434526786208153,
-0.010229273699223995,
0.004869738593697548,
-0.012191608548164368,
-0.01891210302710533,
0.01872127130627632,
0.008521282114088535,
-0.0004090538714081049,
0.004923879634588957,
0.012942196801304817,
-0.0011985581368207932,
-0.0035282187163829803,
0.04641878604888916,
0.0173714067786932,
0.025244370102882385,
0.011342419311404228,
-0.014574563130736351,
0.02482997067272663,
-0.0022385697811841965,
0.02465345896780491,
-0.04088229686021805,
0.017112577334046364,
-0.01594671793282032,
0.02473842352628708,
0.0037993178702890873,
0.014979375526309013,
0.021893732249736786,
0.0068427035585045815,
-0.002505666110664606,
0.01666354387998581,
0.005879020318388939,
0.03555840998888016,
0.011108648031949997,
0.011992663145065308,
-0.004401762969791889,
-0.006119186524301767,
0.006932697258889675,
0.009179354645311832,
-0.030984578654170036,
-0.04639606550335884,
0.004046048037707806,
-0.005797619931399822,
-0.0001920219510793686,
-0.007034613750874996,
-0.032318729907274246,
0.013117482885718346,
0.009986159391701221,
-0.0157146155834198,
0.013795311562716961,
-0.021079901605844498,
0.004390301648527384,
-0.02705351449549198,
-0.02833552658557892,
-0.007729422301054001,
-0.018556416034698486,
-0.016564179211854935,
-0.015540624037384987,
0.011786803603172302,
-0.01580025441944599,
-0.002779727801680565,
0.006555506493896246,
-0.005330956075340509,
-0.016380667686462402,
0.0173491258174181,
-0.007394921965897083,
0.0025969035923480988,
0.03288229554891586,
-0.02878110110759735,
-0.024057790637016296,
0.027233796194195747,
0.008443048223853111,
-0.013008000329136848,
-0.022477610036730766,
-0.012762957252562046,
-0.020001180469989777,
0.015553336590528488,
0.04235193133354187,
-0.015962693840265274,
-0.0019450250547379255,
-0.005171127151697874,
0.00867786817252636,
-0.000830525066703558,
0.011194774881005287,
0.01306971162557602,
0.007375162094831467,
0.010386492125689983,
0.012100601568818092,
0.022587258368730545,
0.017900774255394936,
-0.009223241358995438,
0.02301407977938652,
0.03268365561962128,
0.003823652397841215,
-0.037348322570323944,
0.0002791550359688699,
-0.00033857510425150394,
0.002803690731525421,
-0.0011904658749699593,
-0.011740443296730518,
-0.02286551520228386,
0.021136194467544556,
0.011739648878574371,
0.013800352811813354,
-0.015483729541301727,
-0.026057157665491104,
0.0034959567710757256,
0.002515006810426712,
0.027444150298833847,
-0.018804796040058136,
-0.008893606252968311,
-0.011766765266656876,
-0.00021829712204635143,
-0.0027004131115972996,
-0.01836765930056572,
0.012883350253105164,
-0.01525827031582594,
-0.0008841248927637935,
0.00608889851719141,
0.007424748502671719,
-0.007135828025639057,
-0.004902391694486141,
-0.019923094660043716,
-0.009523309767246246,
0.005524998065084219,
-0.003376358887180686,
-0.008490471169352531,
0.0050088949501514435,
0.0012236787006258965,
-0.0142445657402277,
-0.013309950940310955,
-0.02276449464261532,
-0.007709388621151447,
0.04791121184825897,
-0.026896892115473747,
0.024648137390613556,
-0.0020468411967158318,
0.05612444877624512,
-0.005001028534024954
] | [
0.4441014528274536,
-0.04227957874536514,
-0.1392231285572052,
0.4063710570335388,
0.4484708905220032,
0.14497749507427216,
0.28547120094299316,
-0.009842583909630775,
0.11906201392412186,
-0.861304521560669,
0.35191109776496887,
-0.17677117884159088,
-0.1118103638291359,
0.4383490979671478,
-0.652938187122345,
0.18238329887390137,
0.31450921297073364,
0.4553883969783783,
-0.3037574887275696,
-0.5303323864936829,
-0.32159584760665894,
-0.037458308041095734,
0.3222268223762512,
-0.09410744905471802,
-0.4402664601802826,
-0.014951564371585846,
0.2633371651172638,
-0.6620960235595703,
0.23943428695201874,
0.0019154514884576201,
-0.2823154032230377,
0.29731887578964233,
-0.10995250195264816,
-0.09344609081745148,
-0.7756608128547668,
-0.10189136117696762,
-0.5810871124267578,
-0.08534569293260574,
-0.04829704388976097,
-0.3313083052635193,
-0.5339555144309998,
-0.5685811638832092,
-0.034256793558597565,
0.5407373309135437,
-0.5266584157943726,
-0.3249503970146179,
-1.3137495517730713,
0.6854494214057922,
-0.6078542470932007,
0.12019845098257065,
0.2663809359073639,
-0.22707810997962952,
0.14199721813201904,
0.5528963804244995,
0.09313101321458817,
0.33151060342788696,
-0.5274385213851929,
-0.04395443946123123,
0.48192453384399414,
-0.1558857560157776,
0.06284435093402863,
-0.05867651104927063,
-0.3470194637775421,
0.29983022809028625,
0.3200507164001465,
0.29267171025276184,
0.15584217011928558,
-0.3881639242172241,
-0.5454522967338562,
-0.4044962227344513,
0.17034995555877686,
-0.25368520617485046,
0.18261685967445374,
0.6551651954650879,
-0.12805569171905518,
-0.015332112088799477,
-0.2862090766429901,
-0.05542568117380142,
0.5008242726325989,
-0.23872633278369904,
0.06215095520019531,
0.2461729347705841,
-0.13035428524017334,
-0.17147405445575714,
0.4681611955165863,
0.21005547046661377,
-0.32659757137298584,
0.41405078768730164,
-0.666594922542572,
-0.28958043456077576,
0.25246956944465637,
-0.28896740078926086,
0.397098183631897,
0.2933180630207062,
0.29315173625946045,
0.5304768681526184,
-0.09585630893707275,
-0.44719430804252625,
-0.0679437592625618,
0.333418607711792,
-0.2705267369747162,
0.013119532726705074,
-0.12992644309997559,
-0.752507209777832,
-0.6276491284370422,
-0.5589446425437927,
0.2545529901981354,
-0.09464855492115021,
-0.0688711628317833,
-0.13291703164577484,
-1.0131813287734985,
0.3578866124153137,
-0.32809290289878845,
0.33569076657295227,
-0.3800771236419678,
0.1098344549536705,
0.047838110476732254,
-0.36920925974845886,
-0.052008796483278275,
-0.16462141275405884,
-0.3457295000553131,
1.291515588760376,
0.08721043914556503,
-0.08464694023132324,
0.07004106044769287,
0.23867729306221008,
0.15360930562019348,
0.15637624263763428,
-0.39513134956359863,
0.2033136487007141,
0.21617169678211212,
0.7273640632629395,
-0.1151578426361084,
-0.023798594251275063,
0.2702236771583557,
0.004148606210947037,
0.32624316215515137,
0.2923990786075592,
0.3321021795272827,
0.1449183225631714,
-0.2536524534225464,
-0.4693986177444458,
0.1054646447300911,
0.15944914519786835,
0.08721642196178436,
-0.6796985268592834,
-0.12364570796489716,
-0.26952457427978516,
0.10421369969844818,
-0.2169342041015625,
0.21322394907474518,
-0.3969945013523102,
-0.17713750898838043,
-0.36466309428215027,
0.23022815585136414,
0.4169015884399414,
-0.3873731195926666,
-0.05498101934790611,
0.21670474112033844,
0.43923282623291016,
0.019869953393936157,
-0.1674118936061859,
-0.18746960163116455,
-0.16839009523391724,
0.7183842658996582,
-0.032904379069805145,
0.7155393362045288,
0.876330554485321,
-0.04429088532924652,
0.18033356964588165,
-0.21342912316322327,
-0.10171768069267273,
0.152258962392807,
-0.5751213431358337,
-0.13503441214561462,
0.27824556827545166,
0.13719438016414642,
-0.12987461686134338,
-0.08813144266605377,
0.05132133886218071,
-0.6201722025871277,
0.4089391231536865,
-0.029718032106757164,
-0.5064988732337952,
0.0889107882976532,
0.05321495980024338,
0.22633479535579681,
0.1660589873790741,
-0.43335479497909546,
0.11269545555114746,
-0.3535439074039459,
-0.2933359742164612,
0.5787416100502014,
-0.8547946214675903,
0.9340322613716125,
-0.07949423789978027,
0.15310563147068024,
1.2968708276748657,
-0.2601080536842346,
-0.2594330608844757,
-0.23952381312847137,
-0.26355352997779846,
0.6050195097923279,
-0.07688891142606735,
-0.23458990454673767,
-0.04668422415852547,
0.19445475935935974,
-0.41549065709114075,
0.32516956329345703,
0.03276260197162628,
0.3691558539867401,
-0.10526425391435623,
0.0842260867357254,
0.4996204674243927,
-0.09968259930610657,
-0.12465943396091461,
-0.28195127844810486,
-0.39042404294013977,
-0.6207841038703918,
-0.2535144090652466,
0.005409192759543657,
-0.48346468806266785,
0.7501651048660278,
0.6463586688041687,
0.13315661251544952,
0.3787248134613037,
0.39203596115112305,
-0.10904858261346817,
1.0411754846572876,
-0.33548811078071594,
0.3268027901649475,
-0.47298163175582886,
0.5542876720428467,
-0.23462098836898804,
0.16536585986614227,
0.1865505576133728,
0.07420030236244202,
-0.07582113891839981,
0.04316462576389313,
0.06807569414377213,
-0.3934079706668854,
0.3683260679244995,
-0.6424989700317383,
-0.17339269816875458,
0.17381805181503296,
0.022897018119692802,
-0.31871822476387024,
0.523688793182373,
-1.1225751638412476,
-0.15273909270763397,
-0.07400824874639511,
0.46764063835144043,
0.4651001989841461,
-0.6496735215187073,
-0.09269209951162338,
0.08807692676782608,
-0.1455179899930954,
-0.07844077050685883,
0.004304990638047457,
-0.19767503440380096,
-0.0997147485613823,
0.08009820431470871,
0.350265234708786,
0.09156040847301483,
-0.15453499555587769,
-0.5699820518493652,
-0.8543121218681335,
-0.6443559527397156,
0.8773185610771179,
0.7057991027832031,
1.152305245399475,
-0.04751802235841751,
-0.8990613222122192,
-0.05460500717163086,
-0.2942446768283844,
-0.7630324959754944,
-0.1689438372850418,
0.2502334415912628,
-0.1987456977367401,
0.03595470264554024,
-0.23242172598838806,
0.4348687529563904,
0.5624938607215881,
-0.530366837978363,
-0.32219958305358887,
-0.21257583796977997,
-0.0006086208741180599,
-0.4030607044696808,
-0.05284132808446884,
-0.25145068764686584,
0.16947922110557556,
0.5286771059036255,
-0.05198155716061592,
-0.0581892766058445,
0.6915158629417419,
-0.048302702605724335,
0.24692963063716888,
0.09618162363767624,
0.4100211262702942,
-0.06443285942077637,
-0.20389197766780853,
0.0049612270668148994,
0.09267418086528778,
-0.11552473157644272,
0.08139225095510483,
0.3203217089176178,
0.021766861900687218,
0.3233317732810974,
-5.997241020202637,
-0.1431604027748108,
-0.05165576934814453,
-0.26154255867004395,
0.1071278378367424,
-0.2801439166069031,
1.2191953659057617,
0.29932865500450134,
0.2456335872411728,
0.2118062824010849,
0.3028405010700226,
0.028596626594662666,
0.030951187014579773,
0.23107858002185822,
-0.2561804950237274,
-0.3481428921222687,
-0.36809155344963074,
-0.09688936173915863,
0.37436285614967346,
0.059966400265693665,
-0.05108660086989403,
-0.3281262218952179,
0.17591777443885803,
0.6691438555717468,
-0.057510990649461746,
-0.1543339490890503,
-0.9079073667526245,
-0.14212548732757568,
-0.1814485639333725,
-0.4231714606285095,
-0.10188660770654678,
-0.54142826795578,
0.28595393896102905,
-0.09951633214950562,
0.00042996901902370155,
0.22398997843265533,
0.08340112864971161,
0.378828763961792,
-0.2303391546010971,
-0.21046386659145355,
0.17926624417304993,
0.261349618434906,
-0.0643942579627037,
-0.30004990100860596,
-0.27788376808166504,
0.14494222402572632,
0.37603288888931274,
0.2722002863883972,
-0.028602235019207,
0.7844662666320801,
-0.11384811252355576,
0.046672407537698746,
0.3921281099319458,
0.10864456743001938,
0.2500600218772888,
0.04781131073832512,
0.028076155111193657,
-0.4602898955345154,
-0.44268688559532166,
-0.26136720180511475,
-0.05577946826815605,
-0.32050687074661255,
0.016088025644421577,
-0.7969580292701721,
0.5299772024154663,
0.05729319527745247,
-1.0079877376556396,
-0.43128645420074463,
0.5153831839561462,
-0.23680061101913452,
-0.24530860781669617,
-0.1130247414112091,
0.21165594458580017,
-0.6636121273040771,
0.48628944158554077,
-0.38277626037597656,
0.09946902841329575,
0.09684757888317108,
-0.11537299305200577,
0.07837685942649841,
-0.2378162145614624,
-0.013423139229416847,
-0.4087023138999939,
-0.0068259765394032,
0.284830778837204,
-0.17360597848892212,
-0.6688776612281799,
0.15092167258262634,
-0.4040534496307373,
0.6291124224662781,
0.4721197187900543,
0.1816621571779251,
0.18688219785690308,
0.3735784590244293,
0.07913748174905777,
0.1822030395269394,
-0.018851613625884056,
0.6955271363258362,
0.5594195127487183,
-0.06379956007003784,
0.45165202021598816,
0.06534029543399811,
-0.1593492180109024,
-0.5289013385772705,
-0.29313191771507263,
0.014617524109780788,
-0.7423554062843323,
0.3395601212978363,
0.07684162259101868,
-0.8735737800598145,
-0.24304233491420746,
0.1320059448480606,
-0.4384229779243469,
-0.3062022924423218,
0.37691810727119446,
-0.05509800836443901,
0.03596358373761177,
0.1870788186788559,
1.052145004272461,
-0.2805900275707245,
0.326681911945343,
0.45630982518196106,
-0.9106457829475403,
0.2560058832168579,
-0.3303908109664917,
-0.4470268189907074,
0.15602713823318481,
0.8440920114517212,
-0.3025304079055786,
-0.18702781200408936,
0.34742164611816406,
0.3006117641925812,
-0.33936622738838196,
-0.16757480800151825,
0.2220480889081955,
0.1285209059715271,
-0.31885531544685364,
0.3099992573261261,
-0.10029761493206024,
-0.2000117152929306,
0.4389655590057373,
-0.7461881637573242,
0.4846084415912628,
0.2800682485103607,
0.25903868675231934,
0.06903784722089767,
0.12035548686981201,
-0.012287464924156666,
-0.09380471706390381,
-0.03000190481543541,
0.28816163539886475,
-0.18479236960411072,
0.14798994362354279,
-0.12201850116252899,
-0.37959444522857666,
0.30703669786453247,
0.447170615196228,
-0.16874852776527405,
0.27690911293029785,
-0.7133755087852478,
-0.11464448273181915,
-0.029080213978886604,
-0.360842227935791,
-0.07112181186676025,
-0.3034804165363312,
-0.24962395429611206,
-0.2094668596982956,
-0.1678491234779358,
-0.39568769931793213,
0.1651531457901001,
-0.39701342582702637,
-0.04903232306241989,
-0.17778714001178741,
-0.10578320175409317,
0.07822699099779129,
-0.13785317540168762,
0.18338556587696075,
0.07570090889930725,
-0.3695167601108551,
-0.014528434723615646,
0.09800022095441818,
-0.3062295615673065,
-0.10132795572280884,
0.3484237492084503,
0.6721175312995911,
0.29056891798973083,
-0.1923970878124237,
0.02635730244219303,
-0.8630639910697937,
-0.22836098074913025,
0.25224050879478455,
0.19591857492923737,
0.18676553666591644,
-0.3987610936164856,
-0.05961443483829498,
0.31342461705207825,
-0.12243719398975372,
0.2375820428133011,
0.47770950198173523,
-0.16096943616867065,
0.5984620451927185,
0.03036206029355526,
0.15276089310646057,
0.307400643825531,
0.5848789811134338,
0.0038298824802041054,
-0.6717722415924072,
-0.21468695998191833,
-0.35200801491737366,
-0.25258708000183105,
-0.14947007596492767,
-0.7881362438201904,
-0.20437288284301758,
0.31647199392318726,
0.07560860365629196,
-0.31358662247657776,
0.5342392921447754,
-0.3656834661960602,
-0.08895547688007355,
0.5341439247131348,
0.6256080269813538,
0.5400440096855164,
0.000034224805858684704,
0.003452026518061757,
-0.20202551782131195,
-0.09044952690601349,
0.3517627418041229,
-0.5289515256881714,
0.07430735230445862,
0.027923399582505226,
0.1330326497554779,
-0.3913487195968628,
0.015370344743132591,
-0.07195813953876495,
-0.14953556656837463,
-0.8034368753433228,
0.19365429878234863,
0.24334904551506042,
-0.14554063975811005,
0.12722663581371307,
0.24254566431045532,
0.23595505952835083,
-0.1326594054698944,
-0.04845741391181946,
-0.2450627237558365,
0.5214053392410278,
0.3275480568408966,
-0.958478569984436,
-0.38963955640792847,
0.3587297797203064,
0.2689613103866577,
-0.20507757365703583,
-0.0013119756476953626,
0.7356835603713989,
0.9349175095558167,
0.3284684717655182,
-0.06447109580039978,
-0.5535914301872253,
0.04798082262277603,
0.0760413110256195,
-0.16537244617938995,
-0.1349164992570877,
0.12023560702800751,
-0.11586781591176987,
0.28414082527160645,
-0.09791679680347443,
-0.19781726598739624,
-0.011523429304361343,
0.5114947557449341,
-0.0759151354432106,
0.15706749260425568,
-0.03227856010198593,
0.8728049397468567,
0.7110628485679626,
0.21422111988067627,
0.04621756449341774,
-0.2547982335090637,
0.2060781717300415,
-0.24707524478435516,
0.01009850949048996,
-0.052451349794864655,
-0.5883402824401855,
0.2334461361169815,
-0.2921198010444641,
-0.19797833263874054,
-0.5264012217521667,
0.3815600872039795,
-0.7691691517829895,
0.14666105806827545,
-0.2435571700334549,
-0.2274560034275055,
-0.06842044740915298,
-0.32890060544013977,
-0.4097866415977478,
0.2813354432582855,
0.22264501452445984,
-0.2774564325809479,
0.41261282563209534,
0.0909574031829834,
-0.018621006980538368,
-0.494963675737381,
0.12775178253650665,
0.6548762321472168,
-0.28116753697395325,
-0.27436211705207825,
0.6765422224998474,
0.4404623508453369,
-0.06750129163265228,
-0.6360130906105042,
-0.1362946629524231,
0.26010817289352417,
0.0037229740992188454,
0.23323771357536316,
0.016086509451270103,
0.051605869084596634,
0.05131557956337929,
-0.15614396333694458,
-0.39877304434776306,
0.19614703953266144,
0.06198012828826904,
0.4828191101551056,
0.5724820494651794,
0.5851307511329651,
-0.450709730386734,
-0.011023679748177528,
0.27594733238220215,
0.3424229621887207,
0.00800397526472807,
-0.6937506794929504,
0.7357944250106812,
0.7766541838645935,
0.7983661890029907,
-0.017056526616215706,
0.7126756906509399,
0.3685673773288727,
0.1544375866651535,
-0.3986421525478363,
0.0467752143740654,
0.0370909683406353,
0.5644955039024353,
0.6391403079032898,
0.2305513173341751,
-0.2487855702638626,
0.07354766130447388,
0.10311827808618546,
0.30136871337890625,
-0.058562733232975006,
0.004079910926520824,
0.15509217977523804,
0.16426926851272583,
0.09735650569200516,
-0.8361672759056091,
-0.3970944583415985,
0.40263786911964417,
-0.25874754786491394,
-0.08190841972827911,
0.5885958075523376,
-0.35981154441833496,
-0.22784952819347382,
0.04926586523652077,
-0.5121528506278992,
0.51328444480896,
-0.23464035987854004,
0.3004422187805176,
0.12998110055923462,
-0.01298382505774498,
0.4825419783592224,
0.10883497446775436,
0.3959924280643463,
-0.08963286876678467,
0.23797690868377686,
-0.23566046357154846,
-0.35593801736831665,
-0.1951761394739151,
0.34375330805778503,
-0.23657356202602386,
0.41154050827026367,
0.07053516060113907,
-0.23915384709835052,
0.0503646545112133,
-0.31638607382774353,
-0.12153592705726624,
-0.19628489017486572,
-0.7133550047874451,
-0.19022411108016968,
-0.3574475347995758,
-0.21377547085285187,
-0.26641252636909485,
-0.029253460466861725,
0.35951223969459534,
0.3732646405696869,
-1.1245030164718628,
0.39520370960235596,
0.02655440755188465,
-0.008421255275607109,
0.036857713013887405,
-0.06547817587852478,
0.054946839809417725,
0.33873623609542847,
-0.17035406827926636,
-0.21912194788455963,
0.43344825506210327,
-0.15485650300979614,
0.0447663888335228,
-0.7952315211296082,
0.8806694149971008,
-0.17936208844184875,
-0.19755516946315765,
-0.3669064939022064,
-0.031227560713887215,
1.060138463973999,
0.38497766852378845,
-0.2599775493144989,
0.24009840190410614,
0.05841485783457756,
-0.19876430928707123,
0.2118953913450241,
-0.4275805950164795,
-0.37676528096199036,
-0.38541021943092346,
0.2128651887178421,
-0.3869950771331787,
0.487431138753891,
-0.1357685774564743,
-0.7060246467590332,
0.15832719206809998,
0.5037356615066528,
0.42011505365371704,
-0.17897075414657593,
0.37251517176628113,
-0.36627307534217834,
0.4363618791103363,
-0.5237898230552673,
0.28243231773376465,
-0.5186764597892761,
0.3492099940776825,
-0.28757551312446594,
-0.030512576922774315,
0.012176549062132835,
-0.20452527701854706,
0.09097180515527725,
0.015989182516932487,
0.02180919609963894,
0.15696407854557037,
0.12007500976324081,
0.10993865132331848,
0.00442381389439106,
-0.22336000204086304,
-0.7020092010498047,
-0.12110727280378342,
0.17404556274414062,
0.12890610098838806,
-0.14286305010318756,
0.29707959294319153,
-0.05195796489715576,
-0.6180062294006348,
-0.0010496752802282572,
-0.5526824593544006,
-0.016344258561730385,
0.4706425368785858
] |
The Hippo pathway controls organ size and tissue homeostasis, with deregulation leading to cancer. The core Hippo components in mammals are composed of the upstream serine/threonine kinases Mst1/2, MAPK4Ks and Lats1/2. Inactivation of these upstream kinases leads to dephosphorylation, stabilization, nuclear translocation and thus activation of the major functional transducers of the Hippo pathway, YAP and its paralogue TAZ. YAP/TAZ are transcription co-activators that regulate gene expression primarily through interaction with the TEA domain DNA-binding family of transcription factors (TEAD). The current paradigm for regulation of this pathway centres on phosphorylation-dependent nucleocytoplasmic shuttling of YAP/TAZ through a complex network of upstream components. However, unlike other transcription factors, such as SMAD, NF-κB, NFAT and STAT, the regulation of TEAD nucleocytoplasmic shuttling has been largely overlooked. In the present study, we show that environmental stress promotes TEAD cytoplasmic translocation via p38 MAPK in a Hippo-independent manner. Importantly, stress-induced TEAD inhibition predominates YAP-activating signals and selectively suppresses YAP-driven cancer cell growth. Our data reveal a mechanism governing TEAD nucleocytoplasmic shuttling and show that TEAD localization is a critical determinant of Hippo signalling output. | [
-0.021591197699308395,
-0.0003159455955028534,
0.0019268256146460772,
0.02367158606648445,
0.02164807915687561,
0.008076975122094154,
0.01211879588663578,
0.009245287626981735,
-0.015192370861768723,
0.0054667359218001366,
-0.024623624980449677,
-0.0025375678669661283,
-0.012961586937308311,
0.0333804152905941,
-0.02423671819269657,
0.03398684784770012,
0.006497350987046957,
-0.014179909601807594,
0.011237571015954018,
0.003486438188701868,
0.004060407169163227,
-0.012632263824343681,
0.011882282793521881,
-0.014184391126036644,
0.0013450859114527702,
-0.04191878065466881,
0.005235199350863695,
-0.020289570093154907,
-0.0013307204935699701,
-0.0018072822131216526,
0.023219991475343704,
0.0015053306706249714,
-0.005171488970518112,
-0.006594258360564709,
0.004029586911201477,
0.019325299188494682,
-0.008648236282169819,
0.021166345104575157,
0.011916262097656727,
-0.005578592419624329,
-0.016066832467913628,
-0.011189029552042484,
-0.0010639800457283854,
0.009548219852149487,
-0.008952685631811619,
0.006714561954140663,
-0.003528085071593523,
-0.0020977428648620844,
-0.005862165708094835,
0.005672797095030546,
-0.018748851493000984,
-0.01851721853017807,
-0.006534830201417208,
0.030114248394966125,
-0.00760833453387022,
-0.000021893996745347977,
0.0213648471981287,
-0.0020073140040040016,
-0.021142128854990005,
-0.009592365473508835,
-0.034848347306251526,
-0.02746971696615219,
0.013767772354185581,
-0.005469365045428276,
-0.0071210856549441814,
-0.06665463745594025,
0.0022334009408950806,
0.02283264510333538,
-0.02335679903626442,
-0.015219572931528091,
-0.0032054304610937834,
0.007949958555400372,
-0.01235149335116148,
-0.03818260878324509,
0.0012957628350704908,
0.011453753337264061,
-0.004610662814229727,
0.00889365654438734,
0.020456837490200996,
0.04077186435461044,
0.0040731849148869514,
-0.033031776547431946,
0.019147194921970367,
0.015128977596759796,
0.0020749885588884354,
0.017633099108934402,
-0.01550834346562624,
0.01653400808572769,
-0.007446072064340115,
-0.033013589680194855,
0.008004575967788696,
0.035133711993694305,
-0.00513289263471961,
-0.021127751097083092,
0.019682077690958977,
-0.005335484631359577,
-0.007709318306297064,
0.021448224782943726,
0.02355816960334778,
-0.0035781795158982277,
-0.01621415466070175,
0.02744123712182045,
0.016643714159727097,
-0.025273019447922707,
0.013847891241312027,
0.012687800452113152,
0.008108960464596748,
0.017213765531778336,
0.0027486365288496017,
0.012187507934868336,
-0.014089815318584442,
0.028623176738619804,
-0.01921183057129383,
0.000912786927074194,
0.023101426661014557,
-0.02627992071211338,
-0.012723404914140701,
0.007077107205986977,
0.016879981383681297,
0.003968290984630585,
0.02033764310181141,
-0.0033820844255387783,
-0.012319120578467846,
0.026002299040555954,
0.007348249666392803,
0.000010590068995952606,
0.0015856483951210976,
0.02144724875688553,
-0.005480745807290077,
-0.0028237842489033937,
-0.010021579451858997,
0.020857566967606544,
0.024449294432997704,
0.004618669860064983,
0.022779423743486404,
-0.005009583197534084,
-0.0154414726421237,
-0.015563763678073883,
-0.006448613479733467,
0.004450200591236353,
0.022379696369171143,
0.010426809079945087,
0.010595163330435753,
0.010626381263136864,
0.030194835737347603,
0.007956650108098984,
0.01302467379719019,
-0.0021580220200121403,
0.0016838260926306248,
-0.011125793680548668,
-0.01155240461230278,
0.0013012890703976154,
-0.023958591744303703,
-0.021100535988807678,
-0.012879443354904652,
0.02371189370751381,
-0.03203960135579109,
-0.0178922601044178,
-0.001103027956560254,
0.0029618162661790848,
-0.02899010479450226,
0.011556807905435562,
0.019631290808320045,
0.010599074885249138,
0.014724431559443474,
-0.01923402026295662,
0.020661229267716408,
0.007097412832081318,
0.008024582639336586,
0.008469069376587868,
-0.018846694380044937,
-0.00614888733252883,
-0.0004061218351125717,
0.0072212135419249535,
0.005318972747772932,
-0.002026674570515752,
0.01776619255542755,
0.00963696651160717,
-0.007936065085232258,
0.06649187952280045,
-0.007670215331017971,
0.038387347012758255,
-0.00042847683653235435,
0.012920045293867588,
0.009764838963747025,
-0.018809858709573746,
-0.012293631210923195,
-0.0013751727528870106,
-0.01257470902055502,
0.010029904544353485,
-0.024917766451835632,
-0.045038603246212006,
-0.009453915059566498,
0.01611272245645523,
-0.0020862380042672157,
0.0027847769670188427,
0.018737219274044037,
0.014677542261779308,
-0.02402576617896557,
0.014372863806784153,
0.012297909706830978,
-0.006834808271378279,
0.012565331533551216,
-0.026044536381959915,
-0.025853406637907028,
-0.0060610161162912846,
-0.009842333383858204,
-0.007371616084128618,
-0.00984354317188263,
0.02065345272421837,
0.02442735619843006,
-0.007665626704692841,
-0.007812961004674435,
-0.016933869570493698,
-0.017188413068652153,
0.028269406408071518,
0.0078565189614892,
0.03148810565471649,
-0.0005816682241857052,
-0.012291910126805305,
-0.0007458620821125805,
0.008420338854193687,
0.04120561480522156,
0.021198727190494537,
0.01363416388630867,
-0.0364430770277977,
-0.010586092248558998,
0.019323032349348068,
-0.020433645695447922,
0.012700897641479969,
-0.01011564675718546,
-0.023149415850639343,
-0.018873430788517,
-0.009444930590689182,
0.033531591296195984,
0.008074703626334667,
0.016204874962568283,
-0.03727245703339577,
0.019728271290659904,
-0.00405539758503437,
-0.012826347723603249,
-0.011669364757835865,
0.020430246368050575,
-0.033004581928253174,
-0.013630194589495659,
-0.025997890159487724,
-0.007730273529887199,
0.01677856221795082,
0.02548125386238098,
-0.004876118618994951,
0.01029180083423853,
0.007964035496115685,
0.006431275978684425,
-0.03792734816670418,
0.001638829242438078,
-0.010226795449852943,
-0.02699301764369011,
0.007526726461946964,
0.024868633598089218,
-0.026272863149642944,
0.0017711595864966512,
0.0058882650919258595,
-0.0010478515177965164,
-0.0028608404099941254,
0.02460639551281929,
-0.04763394594192505,
-0.001000650692731142,
-0.00517897866666317,
-0.021974392235279083,
-0.004754547029733658,
0.014988476410508156,
-0.006537127308547497,
0.002059892052784562,
-0.08059614896774292,
-0.014260193333029747,
-0.018909942358732224,
0.0036870380863547325,
0.01316780410706997,
0.007486978080123663,
-0.007551166228950024,
0.001347735058516264,
-0.010101006366312504,
0.003863900201395154,
-0.007211355492472649,
0.01778002455830574,
0.0007354492554441094,
-0.019436487928032875,
-0.019251810386776924,
-0.00935555063188076,
0.014443215914070606,
-0.01254336815327406,
0.020230501890182495,
0.011781476438045502,
-0.00858001783490181,
0.010471475310623646,
-0.025160282850265503,
0.009888671338558197,
-0.030688174068927765,
-0.021492935717105865,
0.015823226422071457,
-0.009262213483452797,
-0.008299736306071281,
0.006714577320963144,
-0.011015499010682106,
-0.0007804030319675803,
-0.023207906633615494,
-0.016906561329960823,
0.0019200542010366917,
-0.013064549304544926,
0.010069640353322029,
0.01667608693242073,
-0.021853791549801826,
0.04588236287236214,
-0.026602253317832947,
0.014332946389913559,
0.017468947917222977,
-0.003299260511994362,
-0.0019805333577096462,
0.020419390872120857,
0.00702351750805974,
-0.016294244676828384,
0.014044800773262978,
-0.0027477822732180357,
-0.004051497206091881,
-0.0071360100992023945,
0.0022003676276654005,
0.021926868706941605,
-0.015341687947511673,
0.004942384082823992,
-0.022116288542747498,
0.027777332812547684,
-0.01073048822581768,
-0.002107710111886263,
-0.03774993494153023,
0.014478233642876148,
-0.006425472442060709,
-0.0029557575471699238,
-0.010427035391330719,
0.028425117954611778,
0.02857520803809166,
-0.0030831352341920137,
-0.004224282223731279,
0.011088328436017036,
0.002613518852740526,
-0.005858094897121191,
-0.03454793244600296,
-0.009946640580892563,
-0.01911354623734951,
-0.0163923017680645,
-0.012064890004694462,
0.0006146510713733733,
0.01489321794360876,
-0.025123372673988342,
-0.048022180795669556,
-0.003206020686775446,
-0.04742840677499771,
-0.009605620987713337,
-0.019365286454558372,
-0.005115104839205742,
0.007530973758548498,
0.015018431469798088,
0.01966742053627968,
-0.020557444542646408,
0.0058303470723330975,
0.007660913281142712,
0.0303831584751606,
0.012337244115769863,
0.0062643676064908504,
-0.004118116106837988,
0.01312694326043129,
-0.03308655321598053,
0.023372773081064224,
0.009991221129894257,
-0.02774175815284252,
0.012292175553739071,
0.02292393147945404,
-0.007720859721302986,
-0.005677280016243458,
0.01662340573966503,
-0.00027301523368805647,
0.007243067491799593,
-0.011898954398930073,
0.003505662316456437,
-0.012090696021914482,
0.0138005455955863,
-0.006653563119471073,
0.009937360882759094,
0.010107791982591152,
-0.005922950338572264,
-0.02873115800321102,
0.00413169153034687,
0.07173669338226318,
0.011589821428060532,
-0.005907275248318911,
-0.00891207717359066,
0.03526502102613449,
-0.016042321920394897,
0.008214651606976986,
0.032461173832416534,
-0.007312661036849022,
-0.012157242745161057,
0.013218080624938011,
-0.02585504949092865,
-0.010245803743600845,
-0.004830130375921726,
-0.025711439549922943,
0.01461044605821371,
-0.021023284643888474,
0.0023239655420184135,
0.011483448557555676,
0.010162612423300743,
-0.01604095660150051,
-0.031169895082712173,
0.00501718744635582,
0.00835595652461052,
-0.011616658419370651,
-0.06385774165391922,
0.026324529200792313,
-0.013603736646473408,
-0.01058374997228384,
0.01313050463795662,
-0.005254929419606924,
0.009896895848214626,
-0.010653017088770866,
0.0041907355189323425,
-0.012408027425408363,
0.01790684089064598,
0.02323467843234539,
-0.011759278364479542,
-0.016076091676950455,
-0.01062966138124466,
0.004019244574010372,
-0.012040670029819012,
-0.019615259021520615,
0.00791741069406271,
0.029551912099123,
0.006741609424352646,
-0.01347358338534832,
-0.009664592333137989,
0.003997676074504852,
-0.018115326762199402,
-0.01768438145518303,
-0.005131360609084368,
0.005284279119223356,
-0.0023180851712822914,
-0.005485430359840393,
0.010850373655557632,
0.05460008233785629,
-0.0003587077371776104,
-0.02035469003021717,
-0.005645337980240583,
-0.016339318826794624,
-0.016030941158533096,
0.014312013052403927,
-0.014495055191218853,
0.037450969219207764,
-0.005480033345520496,
-0.00014674384146928787,
0.008956832811236382,
0.008267967961728573,
0.028271980583667755,
0.010899567976593971,
-0.01644466258585453,
-0.004395513795316219,
-0.005719332955777645,
-0.0317382849752903,
0.0059524960815906525,
0.0031874291598796844,
0.004755469970405102,
0.020909370854496956,
-0.0001054638996720314,
0.000024572014808654785,
0.04472528398036957,
0.02533736266195774,
-0.014188997447490692,
0.017845647409558296,
0.008628549054265022,
-0.004028476774692535,
-0.07437743246555328,
-0.01881333813071251,
-0.007577118463814259,
-0.0006604502559639513,
0.0037979900371283293,
0.01362168975174427,
-0.006190530955791473,
-0.023270729929208755,
-0.007335587404668331,
-0.021284129470586777,
0.004241715185344219,
0.009260686114430428,
0.031926918774843216,
0.028447385877370834,
0.011922989971935749,
0.01666197180747986,
0.01334242895245552,
0.014986646361649036,
-0.02622998133301735,
-0.05432484671473503,
-0.010418263264000416,
0.026317648589611053,
-0.009186415933072567,
0.02226206660270691,
0.006848018150776625,
-0.08029322326183319,
-0.012976406142115593,
0.01802331954240799,
-0.00014408444985747337,
0.0013871616683900356,
-0.025914495810866356,
0.005690255202353001,
0.002815426327288151,
-0.017887592315673828,
-0.016660157591104507,
-0.0038977940566837788,
0.004096570424735546,
0.003349702339619398,
0.01303122192621231,
0.006476720329374075,
-0.01715223491191864,
0.01537879928946495,
0.042154282331466675,
-0.007346986327320337,
0.0057938313111662865,
-0.012182110920548439,
0.002142685931175947,
-0.014683621004223824,
0.0021845099981874228,
-0.007377413101494312,
0.020469915121793747,
-0.011490955017507076,
0.015924056991934776,
-0.00669631315395236,
-0.015903810039162636,
-0.016960684210062027,
-0.023767253383994102,
0.008071641437709332,
-0.007170503493398428,
-0.0256357304751873,
-0.03336095064878464,
0.008142855018377304,
-0.008330738171935081,
-0.01763429120182991,
-0.008877702057361603,
-0.006461004726588726,
-0.012074577622115612,
-0.00718766450881958,
-0.015566825866699219,
-0.00891663134098053,
-0.010369149036705494,
0.0039920201525092125,
-0.00457429513335228,
0.01667853072285652,
-0.004819267429411411,
0.010273316875100136,
0.024207741022109985,
-0.006961319595575333,
0.02309628762304783,
0.037375010550022125,
-0.003282824531197548,
-0.0022385581396520138,
0.012618385255336761,
-0.005147180985659361,
0.0012470227666199207,
-0.008879236876964569,
-0.007534010335803032,
0.0094836987555027,
0.0715491771697998,
0.0026909573934972286,
0.0034679139498621225,
-0.02657165378332138,
-0.008428074419498444,
0.005925772711634636,
0.016455207020044327,
-0.023421984165906906,
-0.014587176963686943,
0.004317956976592541,
-0.015811985358595848,
-0.00758927408605814,
-0.023678582161664963,
0.01655523292720318,
0.03537847474217415,
-0.02399863302707672,
-0.00048007257282733917,
0.024013597518205643,
-0.010113788768649101,
0.0026632994413375854,
-0.0007129870355129242,
-0.01964465342462063,
-0.02935555763542652,
0.03586564585566521,
0.01313529908657074,
-0.003591242479160428,
-0.021919257938861847,
0.04138309881091118,
-0.00875470507889986,
-0.009334352798759937,
-0.01840285025537014,
-0.017869604751467705,
0.000258017098531127,
0.0035940627567470074,
0.012097875587642193,
0.02726690284907818,
0.01594478450715542,
0.01006874069571495,
-0.02101280726492405,
-0.007458935026079416,
0.005594110582023859,
0.0031503508798778057,
0.009402923285961151,
-0.015058310702443123,
-0.020389145240187645,
-0.00032657221890985966,
0.02563825622200966,
-0.025678595528006554,
-0.032937247306108475,
0.010428446345031261,
0.005742537323385477,
0.0009425789467059076,
-0.001883131917566061,
-0.013146506622433662,
0.005687020253390074,
0.0018719225190579891,
-0.0369562953710556,
0.010714121162891388,
-0.022042041644454002,
-0.0014396028127521276,
-0.002164865378290415,
-0.000960217323154211,
0.010063212364912033,
-0.018405765295028687,
0.02805803343653679,
0.00784493237733841,
0.019109701737761497,
-0.012648464180529118,
0.009244045242667198,
0.016112077981233597,
-0.010022182948887348,
0.0030082943849265575,
0.011219754815101624,
0.012145809829235077,
0.020248545333743095,
0.00889316201210022,
0.00975748710334301,
0.024729851633310318,
0.04152335226535797,
0.0022831005044281483,
-0.009795991703867912,
0.009623496793210506,
0.014616630971431732,
0.005704788025468588,
-0.003609753679484129,
-0.01866554468870163,
0.034561797976493835,
-0.00454342644661665,
0.007611890789121389,
0.008103576488792896,
-0.022418566048145294,
0.005606553517282009,
0.002251644153147936,
0.003927312791347504,
0.005125006195157766,
0.03381449729204178,
0.04518916830420494,
0.005204182583838701,
-0.014892003498971462,
0.021247439086437225,
0.0005922210402786732,
-0.026452479884028435,
0.016627237200737,
-0.01728765107691288,
-0.012505978345870972,
-0.005079594906419516,
0.011831285431981087,
0.034145623445510864,
0.016438467428088188,
-0.026579832658171654,
0.0026023034006357193,
0.01787296123802662,
-0.016894612461328506,
-0.03266174718737602,
0.0050476049073040485,
0.03831811249256134,
-0.03211767598986626,
-0.009399525821208954,
0.016742348670959473,
-0.01682952791452408,
0.0031340783461928368,
0.006848431192338467,
-0.01567240059375763,
-0.00986999087035656,
-0.0026872018352150917,
-0.016612982377409935,
-0.01148170605301857,
0.0015548367518931627,
0.021859129890799522,
-0.03813896328210831,
0.026767244562506676,
-0.04239330440759659,
-0.010014185681939125,
-0.014822937548160553,
-0.03189960867166519,
0.02769715152680874,
-0.015744395554065704,
0.03185524791479111,
0.019454240798950195,
0.019411781802773476,
-0.021070150658488274,
-0.012578031048178673,
0.003094808431342244,
0.028925662860274315,
0.007069796789437532,
-0.02218828909099102,
-0.0006489627994596958,
-0.015244870446622372,
0.01239481009542942,
-0.008658729493618011,
0.00594655517488718,
0.0009736809879541397,
0.01829374209046364,
-0.009867273271083832,
-0.014788743108510971,
0.013013284653425217,
0.015879731625318527,
-0.028205804526805878,
-0.013612416572868824,
-0.008387517184019089,
-0.009558456018567085,
-0.006294128485023975,
-0.03389411047101021,
-0.005611422471702099,
0.027672044932842255,
-0.014796563424170017,
0.014985430985689163,
-0.0003681667149066925,
-0.011159124784171581,
0.00925455242395401,
-0.01132045779377222,
0.003436984494328499,
-0.013746319338679314,
-0.005990167148411274,
-0.03107169270515442,
-0.02001815289258957,
-0.02742934226989746,
-0.004904631525278091,
0.02983422391116619,
0.009402886033058167,
0.003182342043146491,
-0.009801064617931843,
-0.006579212844371796,
-0.0093828234821558,
-0.003586025442928076,
-0.0025137760676443577,
-0.014190448448061943,
-0.015918664634227753,
0.0060910689644515514,
0.015832658857107162,
-0.038993943482637405,
-0.037167321890592575,
0.004967617802321911,
-0.0011140820570290089,
-0.016968529671430588,
-0.00840634573251009,
0.005549486726522446,
-0.0423511266708374,
0.006208488717675209,
-0.013819913379848003,
-0.008534710854291916,
-0.010658254846930504
] | [
0.027121247723698616,
0.13291780650615692,
0.022326001897454262,
0.17383083701133728,
0.02385232225060463,
0.4517192840576172,
-0.001110365497879684,
-0.03891570121049881,
-0.013771501369774342,
-0.4329630434513092,
0.030266186222434044,
0.30087152123451233,
-0.7589937448501587,
-0.35632890462875366,
-0.17044252157211304,
0.0019682571291923523,
0.5072891712188721,
0.6408467888832092,
-0.08779839426279068,
-0.4089139699935913,
0.077090784907341,
-0.18072551488876343,
0.5044929385185242,
-0.10271723568439484,
0.4966382086277008,
-0.019619453698396683,
-0.12096574902534485,
-0.14387387037277222,
0.6128677129745483,
-0.02735867351293564,
-0.13961900770664215,
0.7383667826652527,
-0.017910873517394066,
-0.06445368379354477,
-0.40518057346343994,
-0.1663787066936493,
-0.45597848296165466,
-0.08273527026176453,
0.07861416041851044,
0.11808382719755173,
-0.43330633640289307,
0.07788467407226562,
-0.2571132183074951,
0.3493799865245819,
-0.23217453062534332,
-0.3395465016365051,
-1.0249335765838623,
1.0316240787506104,
-0.26017093658447266,
0.1452345997095108,
-0.5728206038475037,
0.42150962352752686,
-0.018172550946474075,
0.3979856073856354,
0.28389623761177063,
-0.2606133222579956,
-0.5824134945869446,
-0.034376081079244614,
0.2846885621547699,
-0.8826184272766113,
-0.16075623035430908,
0.2003145068883896,
-0.14997383952140808,
0.04712672159075737,
-0.006354425102472305,
0.3189656138420105,
-0.29058364033699036,
-0.1464463472366333,
-0.7346600294113159,
0.1891775280237198,
-0.11949131637811661,
-0.2750001847743988,
-0.5007327198982239,
0.3179578185081482,
-0.0032108905725181103,
-0.48819857835769653,
-0.262521892786026,
-0.03852411359548569,
0.19231650233268738,
0.48626217246055603,
0.4733796715736389,
-0.0809023529291153,
0.38687044382095337,
0.36634209752082825,
0.3972220718860626,
0.2371187061071396,
0.05024750158190727,
0.24981683492660522,
-0.42177310585975647,
-0.46222591400146484,
0.027235373854637146,
-0.06026732176542282,
0.2107943743467331,
0.03212418407201767,
-0.13253523409366608,
0.45855480432510376,
0.5743486881256104,
-0.3070757985115051,
-0.38882046937942505,
-0.2365807592868805,
-0.45481500029563904,
0.1079888716340065,
0.05787091329693794,
-0.713943362236023,
-0.578923225402832,
-0.3637838661670685,
0.25301629304885864,
-0.5034657716751099,
0.12003117054700851,
-0.08457370102405548,
-0.9284799098968506,
-0.2898801863193512,
-0.3900834918022156,
-0.13974927365779877,
0.2794532775878906,
0.05000988766551018,
-0.020950334146618843,
-0.2610950767993927,
0.20202258229255676,
-0.2260609120130539,
-0.20186103880405426,
1.3192390203475952,
0.06720596551895142,
0.5292934775352478,
-0.07945838570594788,
-0.06348007172346115,
0.19384969770908356,
-0.26539450883865356,
0.3947102725505829,
0.444339394569397,
0.36494776606559753,
0.6328920125961304,
-0.006561224814504385,
-0.29563406109809875,
0.018105441704392433,
0.31124815344810486,
0.7087860703468323,
0.2760489881038666,
0.7628540396690369,
0.44798946380615234,
-0.2857142388820648,
-0.7646546363830566,
-0.1385864019393921,
-0.29067766666412354,
-0.34642505645751953,
-0.7267133593559265,
-0.6165075898170471,
-0.19654910266399384,
0.43088963627815247,
-0.5551658868789673,
0.28046944737434387,
-0.42368772625923157,
-0.28063181042671204,
-0.011040905490517616,
0.037550147622823715,
0.3705711364746094,
0.27039238810539246,
-0.20308320224285126,
0.012434006668627262,
0.04168400168418884,
0.3897215723991394,
-0.5092052817344666,
-0.14058034121990204,
-0.31575748324394226,
0.38367000222206116,
0.15032251179218292,
0.6162601709365845,
0.6399010419845581,
-0.08945459127426147,
-0.1575080156326294,
-0.3099471628665924,
-0.6900660395622253,
0.48800885677337646,
-0.08428073674440384,
-0.14609462022781372,
-0.22065335512161255,
0.26776379346847534,
-0.296673446893692,
0.1167389377951622,
0.07246201485395432,
-0.7119579315185547,
0.050953056663274765,
-0.2769199013710022,
-0.42405930161476135,
0.5590565800666809,
-0.13358239829540253,
0.4880865514278412,
-0.30006107687950134,
-0.08754221349954605,
-0.04090328514575958,
-0.20752763748168945,
-0.5390384197235107,
0.9511755704879761,
-0.05732739344239235,
1.1235102415084839,
-0.631894588470459,
-0.41477876901626587,
0.3292243182659149,
0.43979308009147644,
-0.11013658344745636,
-0.5658704042434692,
-0.43899139761924744,
0.4281047284603119,
-0.39119359850883484,
-0.843441367149353,
-0.1660560667514801,
-0.23884646594524384,
-0.24530884623527527,
0.26172468066215515,
-0.3348192572593689,
-0.14154252409934998,
-0.3385898470878601,
-0.2306874692440033,
-0.006063967011868954,
0.3301929235458374,
-0.826141893863678,
-0.29751771688461304,
0.028352415189146996,
-0.49847131967544556,
-0.11581812053918839,
0.030938029289245605,
-0.41283944249153137,
0.43730804324150085,
0.7388800382614136,
0.1271040290594101,
0.5093602538108826,
0.9804614186286926,
0.5285006165504456,
0.6134033203125,
-0.41967883706092834,
0.6190378069877625,
-0.525611937046051,
-0.2771974503993988,
-0.6690459847450256,
0.18873290717601776,
0.002944755833595991,
-0.06864388287067413,
-0.16702121496200562,
0.004070274531841278,
-0.6875365376472473,
-0.17337505519390106,
0.7284728288650513,
-0.9514006972312927,
-0.395160049200058,
0.22472375631332397,
-0.43434593081474304,
-0.35713791847229004,
0.20513421297073364,
-1.2298647165298462,
0.13669097423553467,
-0.5104937553405762,
0.7060421109199524,
0.27118998765945435,
-0.5261259078979492,
0.22040417790412903,
-0.17203137278556824,
0.4193474054336548,
0.09913267195224762,
0.07901795953512192,
-0.3781774938106537,
-0.03760619834065437,
-0.2913292646408081,
-0.11382463574409485,
0.2838711142539978,
0.070611871778965,
-0.3985881805419922,
-0.22384198009967804,
-0.15553583204746246,
1.1917210817337036,
0.5691946148872375,
1.1204485893249512,
-0.30011725425720215,
-0.2664487361907959,
0.05989229679107666,
0.04079089313745499,
-0.4632800817489624,
0.04992320016026497,
0.2205536663532257,
-0.15707655251026154,
-0.5633549690246582,
-0.008024252951145172,
0.08247529715299606,
0.8091415762901306,
-0.18480408191680908,
-0.3642938733100891,
0.31939461827278137,
0.15561404824256897,
-0.3552982211112976,
0.1339699774980545,
-0.18056175112724304,
0.01795348897576332,
0.1772167682647705,
0.03727676719427109,
-0.18582463264465332,
0.359188437461853,
0.0324191153049469,
-0.013673083856701851,
0.8273727297782898,
0.14061275124549866,
-0.11542626470327377,
-0.2396782636642456,
0.29407021403312683,
0.0942077785730362,
-0.19290252029895782,
0.18843838572502136,
0.5097907185554504,
-0.2732466161251068,
0.23474015295505524,
-5.7533464431762695,
-0.04459317401051521,
0.1320761889219284,
-0.852044403553009,
-0.0047725168988108635,
0.15581637620925903,
0.7660449147224426,
0.11288706958293915,
0.12635572254657745,
0.4238114356994629,
0.3480242192745209,
0.09054609388113022,
-0.3176996111869812,
-0.07285309582948685,
0.02967248670756817,
-0.2681594789028168,
-0.5634167194366455,
-0.4491720199584961,
0.5399236083030701,
-0.18368595838546753,
0.3874324858188629,
-0.8384377956390381,
-0.06309448927640915,
0.5518956184387207,
-0.16300302743911743,
-0.24918703734874725,
-0.2902110517024994,
-0.4765261113643646,
-0.22652775049209595,
-0.40370655059814453,
-0.028321262449026108,
-0.6052979230880737,
0.1384185403585434,
-0.1310485154390335,
0.42837274074554443,
-0.6045591831207275,
0.002953644609078765,
0.308276891708374,
-0.28831613063812256,
-0.16401568055152893,
0.4121610224246979,
0.008630368858575821,
0.029195325449109077,
-0.615914523601532,
0.12136495858430862,
0.23882651329040527,
-0.3156183660030365,
-0.20940828323364258,
-0.822576642036438,
0.7273005247116089,
0.21313081681728363,
-0.30166468024253845,
-0.27781328558921814,
0.21134619414806366,
0.9193760752677917,
0.4596041142940521,
0.27479156851768494,
-0.2785618305206299,
-0.2859816253185272,
-0.016078338027000427,
0.014404529705643654,
-0.28777995705604553,
-0.4039810001850128,
-0.35529664158821106,
0.24570167064666748,
0.5900254249572754,
-0.648578405380249,
-0.5922806262969971,
0.3795088529586792,
-0.03564797341823578,
0.05610805004835129,
-0.10944739729166031,
-0.18273061513900757,
-0.8635762333869934,
-0.036230847239494324,
-0.38826122879981995,
0.3553805649280548,
0.3717210590839386,
-0.10500854253768921,
-0.3059627115726471,
-0.4140702188014984,
-0.09180606156587601,
-0.09146047383546829,
-0.39643552899360657,
-0.07970808446407318,
0.026067636907100677,
-0.9282636642456055,
-0.08306795358657837,
0.12625163793563843,
0.5819673538208008,
0.717591404914856,
-0.44581499695777893,
-0.008148705586791039,
0.6233739852905273,
0.09902672469615936,
0.40010881423950195,
0.3561534583568573,
0.4024890065193176,
0.22386358678340912,
0.2535892426967621,
0.4299373924732208,
0.3336693346500397,
-0.7958348989486694,
-0.12897059321403503,
-0.5405803322792053,
0.5326602458953857,
-0.6405283212661743,
0.3831188678741455,
0.7657409906387329,
-0.8347702026367188,
0.010171549394726753,
0.032916370779275894,
-0.13174587488174438,
-0.6040222644805908,
0.6814340353012085,
-0.39116111397743225,
-0.35326024889945984,
0.2751554548740387,
0.9715397357940674,
-0.6612419486045837,
-0.11111385375261307,
0.5104632377624512,
-0.6362718939781189,
0.4590160846710205,
-0.7676638960838318,
0.11906791478395462,
0.09175916761159897,
0.526888906955719,
-0.8420910239219666,
-0.11251605302095413,
0.1988411396741867,
-0.013595695607364178,
0.13366259634494781,
0.4439726769924164,
0.21957562863826752,
-0.18011868000030518,
-0.021579056978225708,
0.5212728381156921,
0.6818560361862183,
-0.28966987133026123,
0.1121472716331482,
0.1576702892780304,
-0.20514421164989471,
-0.06962838023900986,
0.3204391598701477,
0.16152963042259216,
-0.39631086587905884,
0.04873393848538399,
-0.25976765155792236,
-0.03224977105855942,
0.540617048740387,
-0.18492864072322845,
0.027944518253207207,
0.3361494541168213,
-0.20370863378047943,
0.1861063688993454,
0.06076588109135628,
0.08069013059139252,
0.5991516709327698,
-0.4867170453071594,
0.39427027106285095,
0.05595910921692848,
-0.8032286167144775,
-0.26448488235473633,
-0.37648069858551025,
-0.4326982796192169,
0.18225248157978058,
-0.6222147345542908,
-0.44087111949920654,
-0.3187464773654938,
-0.03591219335794449,
-0.17204128205776215,
0.48955655097961426,
0.09616450220346451,
-0.2613893747329712,
-0.5412029027938843,
-0.27974334359169006,
-0.00710335886105895,
-0.2835462987422943,
0.4145376980304718,
0.05909648537635803,
-0.31138721108436584,
0.19007959961891174,
-0.09425574541091919,
-0.18202514946460724,
-0.007814151234924793,
0.13978131115436554,
-0.04426614195108414,
0.2750934660434723,
-0.19172421097755432,
0.36315250396728516,
0.06475830078125,
-0.021146247163414955,
-0.027119483798742294,
0.49675628542900085,
0.4859597682952881,
-0.01293980237096548,
0.41190826892852783,
-0.12688089907169342,
-0.7055736780166626,
0.245441734790802,
0.08951279520988464,
0.011876555159687996,
0.1713276505470276,
0.6739180684089661,
0.33953699469566345,
-0.0039011696353554726,
0.19511531293392181,
-0.3241729140281677,
0.07012855261564255,
-0.19682829082012177,
-0.6720342636108398,
-0.01279862318187952,
0.08766011148691177,
-0.1262134164571762,
-0.04644772782921791,
0.4286190867424011,
-0.18237392604351044,
-0.4423202872276306,
0.037640996277332306,
0.6197906136512756,
0.20846234261989594,
-0.20987491309642792,
-0.317963182926178,
-0.14401081204414368,
0.3611740469932556,
0.1521633416414261,
-0.6335369348526001,
0.732776939868927,
-0.2932366132736206,
-0.5452170968055725,
0.05064978823065758,
-0.009212130680680275,
0.36253321170806885,
-0.18171744048595428,
-0.7536212205886841,
-0.6279036998748779,
0.08307080715894699,
0.0820983275771141,
0.5713615417480469,
0.3217816650867462,
0.5225365161895752,
-0.5011957883834839,
0.5283393859863281,
-0.1173359826207161,
0.36255761981010437,
0.0778881087899208,
-0.5295044183731079,
-0.22844384610652924,
-0.29146668314933777,
0.6607454419136047,
0.057068902999162674,
0.18470241129398346,
0.6956573128700256,
0.6764851212501526,
0.33792102336883545,
0.05762752890586853,
-0.14757567644119263,
-0.20586517453193665,
0.25047606229782104,
-0.2743610739707947,
-0.11455751210451126,
0.015572006814181805,
0.3803328275680542,
0.5261855721473694,
0.10870654135942459,
-0.15283168852329254,
-0.7065029740333557,
0.6181351542472839,
-0.20529961585998535,
0.34851768612861633,
0.24687081575393677,
0.6862090229988098,
-0.08727924525737762,
0.016094109043478966,
0.09269464015960693,
-0.2808520495891571,
0.38297802209854126,
0.24207593500614166,
0.22864651679992676,
-0.004690621048212051,
-0.327275812625885,
0.9131191968917847,
-0.17792090773582458,
0.5036018490791321,
-0.9718067049980164,
0.38412487506866455,
-0.8415926098823547,
0.02370176836848259,
-0.12045256793498993,
-0.38970956206321716,
0.06875749677419662,
-0.681689977645874,
-0.4824334383010864,
0.27644556760787964,
0.4233243763446808,
0.44547829031944275,
0.14133475720882416,
-0.1272617131471634,
0.31594061851501465,
-0.7969614863395691,
-0.05806930363178253,
0.5429380536079407,
0.08450892567634583,
-0.10341624170541763,
0.13638029992580414,
0.11751653254032135,
-0.2908385992050171,
-0.9622212648391724,
-0.3097686171531677,
-0.13927452266216278,
-0.04487278684973717,
0.5637624263763428,
-0.058946505188941956,
-0.27893704175949097,
0.3485189378261566,
-0.20972104370594025,
0.02963498793542385,
0.32648375630378723,
0.30653247237205505,
0.1943674385547638,
0.4052117168903351,
0.40917712450027466,
-0.206337109208107,
-0.05044275149703026,
0.02911961078643799,
0.35431018471717834,
0.5469992160797119,
0.5216747522354126,
0.8186602592468262,
0.7251108884811401,
0.34189891815185547,
0.415723592042923,
0.747414767742157,
0.447902113199234,
-0.030230959877371788,
-0.14344638586044312,
-0.5326400995254517,
-0.46636855602264404,
-0.08055731654167175,
1.0091243982315063,
0.35937684774398804,
-0.12984973192214966,
-0.028105711564421654,
0.32024651765823364,
0.3091215193271637,
-0.00565564539283514,
0.16771797835826874,
-0.2505229413509369,
0.527687668800354,
0.3476492762565613,
-0.5262016654014587,
-0.7289273142814636,
0.09461834281682968,
-0.3681042492389679,
0.4093354642391205,
0.3550839126110077,
0.26179662346839905,
-0.26951864361763,
0.42039209604263306,
-0.47789835929870605,
0.4810907542705536,
0.16925616562366486,
0.6842992901802063,
-0.24401037395000458,
0.3454098105430603,
0.09269734472036362,
-0.01922975853085518,
0.5317546129226685,
0.07144353538751602,
-0.25466200709342957,
0.3823395371437073,
-0.2500063478946686,
-0.03461109846830368,
0.11406901478767395,
-0.3323803246021271,
-0.12691040337085724,
-0.10575342178344727,
0.27094271779060364,
0.121002197265625,
-0.34458261728286743,
-0.14349819719791412,
-0.25077787041664124,
-0.83207768201828,
-0.06316268444061279,
0.03536992520093918,
-0.40145769715309143,
-0.8217902183532715,
-0.13446873426437378,
-0.044174227863550186,
-0.057210296392440796,
-0.6166833639144897,
0.8633379340171814,
-0.13781672716140747,
0.19884490966796875,
0.038718607276678085,
0.06938081979751587,
-0.167818084359169,
0.36858803033828735,
0.11778564006090164,
0.27750664949417114,
0.27861225605010986,
-0.22791160643100739,
0.05830225348472595,
-0.10897006094455719,
0.554340660572052,
-0.14639943838119507,
-0.5163705348968506,
-0.4999035894870758,
-0.10183314979076385,
0.8966986536979675,
0.5606021881103516,
-0.08545977622270584,
0.5947465896606445,
0.44193235039711,
0.6194526553153992,
0.2503148317337036,
-0.3110705316066742,
-0.07608948647975922,
-0.6291361451148987,
-0.036246106028556824,
-0.6741775274276733,
0.679894745349884,
-0.25919637084007263,
0.053338080644607544,
0.11151634901762009,
0.7399764060974121,
0.10620194673538208,
-0.3042885363101959,
0.25916817784309387,
-0.4190768897533417,
0.12152454257011414,
-0.6313459873199463,
-0.28519317507743835,
-0.5618605017662048,
0.27603960037231445,
-0.29792699217796326,
-0.08055511116981506,
-0.11441479623317719,
-0.32215872406959534,
0.11787541210651398,
0.3439409136772156,
0.08884607255458832,
0.359620064496994,
0.22196999192237854,
-0.07658654451370239,
-0.34547075629234314,
-0.7819434404373169,
-0.9193788170814514,
0.16220176219940186,
-0.021094853058457375,
-0.07362032681703568,
-0.20441946387290955,
-0.004413850139826536,
-0.03623487800359726,
-0.3476579189300537,
0.465873122215271,
0.0764026865363121,
-0.1739114224910736,
0.29180970788002014
] |
CONTEXT Diagnostic lumbar punctures (LPs), commonly used to rule out meningitis, are associated with adverse events. OBJECTIVE To systematically review the evidence about diagnostic LP techniques that may decrease the risk of adverse events and the evidence about test accuracy of cerebrospinal fluid (CSF) analysis in adult patients with suspected bacterial meningitis. DATA SOURCES We searched the Cochrane Library, MEDLINE (using Ovid and PubMed) from 1966 to January 2006 and EMBASE from 1980 to January 2006 without language restrictions to identify relevant studies and identified others from the bibliographies of retrieved articles. STUDY SELECTION We included randomized trials of patients aged 18 years or older undergoing interventions to facilitate a successful diagnostic LP or to potentially reduce adverse events. Studies assessing the accuracy of biochemical analysis of the CSF for possible bacterial meningitis were also identified. DATA EXTRACTION Two investigators independently appraised study quality and extracted relevant data. For studies of the LP technique, data on the intervention and the outcome were extracted. For studies of the laboratory diagnosis of bacterial meningitis, data on the reference standard and test accuracy were extracted. DATA SYNTHESIS We found 15 randomized trials. A random-effects model was used for quantitative synthesis. Five studies of 587 patients compared atraumatic needles with standard needles and found a nonsignificant decrease in the odds of headache with an atraumatic needle (absolute risk reduction [ARR], 12.3%; 95% confidence interval [CI], -1.72% to 26.2%). Reinsertion of the stylet before needle removal decreased the risk of headache (ARR, 11.3%; 95% CI, 6.50%-16.2%). The combined results from 4 studies of 717 patients showed a nonsignificant decrease in headache in patients who were mobilized after LP (ARR, 2.9%; 95% CI, -3.4 to 9.3%). Four studies on the accuracy of biochemical analysis of CSF in patients with suspected meningitis met inclusion criteria. A CSF-blood glucose ratio of 0.4 or less (likelihood ratio [LR], 18; 95% CI, 12-27]), CSF white blood cell count of 500/muL or higher (LR, 15; 95% CI, 10-22), and CSF lactate level of 31.53 mg/dL or more (> or =3.5 mmol/L; LR, 21; 95% CI, 14-32) accurately diagnosed bacterial meningitis. CONCLUSIONS These data suggest that small-gauge, atraumatic needles may decrease the risk of headache after diagnostic LP. Reinsertion of the stylet before needle removal should occur and patients do not require bed rest after the procedure. Future research should focus on evaluating interventions to optimize the success of a diagnostic LP and to enhance training in procedural skills. | [
0.009910235181450844,
-0.003158760955557227,
-0.022100280970335007,
0.012119162827730179,
0.007827584631741047,
0.02973555214703083,
0.008811361156404018,
0.016677197068929672,
-0.009360222145915031,
0.025795022025704384,
0.010115845128893852,
0.01339106634259224,
0.011843198910355568,
0.014133596792817116,
0.022941038012504578,
0.0025135851465165615,
-0.030919738113880157,
0.01008324883878231,
0.011945524252951145,
0.007334102876484394,
0.0167912095785141,
-0.02962622232735157,
0.010132471099495888,
0.02725985273718834,
-0.003954814746975899,
-0.005413726903498173,
-0.0032165711745619774,
0.014614786952733994,
0.020523101091384888,
-0.011764191091060638,
-0.015062409453094006,
0.0002813328756019473,
0.002986000617966056,
0.0028995536267757416,
0.004984939005225897,
-0.0029594716615974903,
-0.0022384433541446924,
0.014031864702701569,
-0.01206845510751009,
-0.005322196986526251,
0.010538130067288876,
-0.006010652519762516,
0.005484378896653652,
-0.015711581334471703,
-0.009921903721988201,
-0.007285602856427431,
-0.002801555674523115,
-0.014497158117592335,
-0.001140969805419445,
0.008512688800692558,
-0.013196386396884918,
-0.0214666947722435,
-0.010715693235397339,
-0.01870081014931202,
-0.005890583619475365,
-0.018482297658920288,
0.018912672996520996,
0.019850779324769974,
0.004286753013730049,
0.006083386484533548,
-0.010688234120607376,
0.028966311365365982,
0.011959055438637733,
-0.019069228321313858,
-0.011394614353775978,
-0.06647348403930664,
0.010811151936650276,
0.0033268299885094166,
0.019379019737243652,
-0.017851637676358223,
-0.000024091918021440506,
0.009273925796151161,
-0.024665500968694687,
-0.003820793703198433,
0.02652829885482788,
0.0015733838081359863,
-0.009304468519985676,
0.01479683443903923,
-0.0002269649412482977,
-0.018942855298519135,
-0.004365046042948961,
-0.0034425370395183563,
-0.01882312074303627,
0.03260500356554985,
-0.0021923487074673176,
-0.0072319768369197845,
-0.020055027678608894,
0.00601580273360014,
0.008949002251029015,
-0.00011783069930970669,
0.017917480319738388,
-0.001670254860073328,
-0.0144150760024786,
0.010905511677265167,
0.0076605454087257385,
-0.023688338696956635,
-0.013850182294845581,
0.006015145219862461,
0.013699578121304512,
-0.011068018153309822,
-0.021015528589487076,
0.019447382539510727,
0.02360062301158905,
-0.01573159545660019,
-0.02205473929643631,
0.010154611431062222,
-0.013433542102575302,
0.021871529519557953,
-0.013988712802529335,
0.013089695945382118,
0.005417848937213421,
-0.024494661018252373,
-0.011674774810671806,
-0.0023637511767446995,
0.006258400157094002,
-0.018783971667289734,
0.009494878351688385,
0.004156134091317654,
0.006445086095482111,
-0.02306799590587616,
0.03650025278329849,
0.0056646112352609634,
0.004588300362229347,
-0.00894924346357584,
-0.0009133279090747237,
0.007470772601664066,
-0.017777055501937866,
-0.011248048394918442,
0.008146043866872787,
-0.0017446130514144897,
-0.009474825114011765,
0.00783329177647829,
-0.012190432287752628,
-0.0038864666130393744,
0.0023186076432466507,
0.006535626947879791,
0.0035783150233328342,
-0.004395463038235903,
0.005011091940104961,
-0.014696190133690834,
-0.008514031767845154,
0.011328374035656452,
0.0017582434229552746,
0.01092219352722168,
-0.01245645247399807,
0.007685007061809301,
0.011181461624801159,
-0.013314650394022465,
-0.007031806744635105,
0.0057760197669267654,
0.011205659247934818,
-0.003995348699390888,
-0.016800004988908768,
-0.015074816532433033,
-0.014764366671442986,
0.005629478953778744,
-0.013911077752709389,
0.019464872777462006,
-0.003604798810556531,
0.006976855918765068,
0.0048398831859230995,
0.002430038060992956,
0.004918641410768032,
0.010507342405617237,
-0.011325989849865437,
0.035964444279670715,
-0.005807217676192522,
-0.026607995852828026,
-0.015657274052500725,
0.0022104294039309025,
-0.011044041253626347,
0.01747688092291355,
-0.03125233203172684,
0.006968323141336441,
-0.016898714005947113,
0.0007929465500637889,
0.01940750516951084,
0.00936089176684618,
-0.013508343137800694,
0.06578665971755981,
0.0107719162479043,
-0.001972272526472807,
-0.0010074770543724298,
-0.011522196233272552,
-0.0014293938875198364,
-0.003111021127551794,
0.008476674556732178,
-0.005138141103088856,
0.014559635892510414,
-0.004654044285416603,
-0.007757461164146662,
-0.030708832666277885,
-0.009540319442749023,
-0.0016531171277165413,
-0.02481035515666008,
0.00307326577603817,
0.0026337243616580963,
-0.00018706684932112694,
0.014761876314878464,
-0.01206204853951931,
0.027603046968579292,
-0.006368822883814573,
-0.017277415841817856,
-0.0009716066997498274,
0.021602459251880646,
0.012385506182909012,
0.014722616411745548,
-0.025042302906513214,
0.013394784182310104,
0.022807752713561058,
-0.0011654850095510483,
0.010203312151134014,
0.005733184050768614,
-0.004633928183466196,
-0.012817221693694592,
-0.010310186073184013,
0.0026881485246121883,
-0.010294444859027863,
-0.006182918790727854,
-0.014258014038205147,
0.0030729984864592552,
-0.010709359310567379,
-0.012708861380815506,
-0.0040297373197972775,
-0.00022352830274030566,
-0.013970611616969109,
-0.001364679541438818,
0.009018509648740292,
0.0018515684641897678,
0.008002746850252151,
-0.0012145740911364555,
0.01112401857972145,
-0.013648387975990772,
0.02141927368938923,
0.012331387028098106,
-0.005351630039513111,
0.01434672623872757,
0.002432713285088539,
0.01476831454783678,
-0.011940785683691502,
0.005905574653297663,
-0.005764132831245661,
-0.010438619181513786,
-0.0027341737877577543,
0.027578797191381454,
-0.0007993667386472225,
-0.016322951763868332,
-0.003665830008685589,
-0.0010829810053110123,
0.0007301150471903384,
0.006798196118324995,
-0.03327064588665962,
-0.009335249662399292,
-0.014894711785018444,
-0.0002544641029089689,
-0.011737814173102379,
-0.0037010046653449535,
-0.011426491662859917,
0.023213354870676994,
-0.04349856078624725,
0.00766782509163022,
0.004249900113791227,
-0.004855824168771505,
0.022266477346420288,
0.008427941240370274,
0.005037511233240366,
-0.01371072418987751,
0.03349936008453369,
0.002111675450578332,
-0.008228856138885021,
0.005884457379579544,
-0.007977072149515152,
-0.011018292047083378,
-0.08043301850557327,
-0.0175358634442091,
-0.006732103414833546,
0.02714168094098568,
0.015123682096600533,
0.007201199885457754,
-0.012007234618067741,
-0.0027442551217973232,
-0.012419385835528374,
-0.02561628445982933,
-0.0023417528718709946,
0.02840418368577957,
-0.003956674598157406,
0.010326755233108997,
-0.010133187286555767,
-0.007672895677387714,
0.011614769697189331,
-0.013744788244366646,
0.006736088544130325,
0.007109466474503279,
0.0022775144316256046,
-0.03507036343216896,
0.022272542119026184,
-0.000490311998873949,
-0.009290844202041626,
0.013153946958482265,
0.02781817317008972,
0.0046602957881987095,
0.006852101534605026,
0.012909796088933945,
-0.009202069602906704,
0.0032049338333308697,
0.00847302470356226,
-0.013740535825490952,
-0.0003061556490138173,
0.003943272866308689,
-0.011822408065199852,
0.014402519911527634,
-0.003880106844007969,
0.038176458328962326,
0.0023406606633216143,
0.017171580344438553,
0.0011681513860821724,
0.0006780140101909637,
-0.0053780293092131615,
0.021903302520513535,
0.006974048912525177,
0.007793286815285683,
0.014598829671740532,
-0.011158203706145287,
-0.012631307356059551,
-0.0026459554210305214,
-0.00612651975825429,
0.013179429806768894,
-0.01873842254281044,
-0.008167644031345844,
-0.02092144265770912,
0.008050823584198952,
-0.008672826923429966,
-0.01438806764781475,
-0.03149337321519852,
-0.007534774951636791,
-0.010668089613318443,
0.023426150903105736,
0.005126812495291233,
-0.006896179169416428,
0.01837681606411934,
-0.02509319968521595,
-0.0033166473731398582,
0.02617330104112625,
0.029770981520414352,
0.002666972577571869,
0.010367143899202347,
-0.008822770789265633,
-0.009136971086263657,
-0.00767775671556592,
-0.010722799226641655,
0.0063440254889428616,
0.0035066199488937855,
0.020761117339134216,
0.0371415838599205,
0.004886784125119448,
0.018295785412192345,
-0.00457319850102067,
-0.02270452119410038,
0.023536143824458122,
0.008552632294595242,
-0.003537742653861642,
0.017657514661550522,
-0.016450071707367897,
0.04764222353696823,
-0.008659329265356064,
-0.01384595688432455,
0.014336196705698967,
-0.01822860911488533,
0.010424950160086155,
0.00028351356741040945,
-0.023915693163871765,
0.0121591966599226,
0.008229994215071201,
-0.004520617891103029,
-0.008656035177409649,
-0.014359213411808014,
-0.013339750468730927,
-0.008251840248703957,
0.007161891087889671,
-0.00013558333739638329,
-0.00817850697785616,
0.0004672873765230179,
-0.0030703896190971136,
-0.0008931877091526985,
-0.0043297987431287766,
-0.001241594087332487,
0.011901509948074818,
0.005185064859688282,
0.024632979184389114,
0.00727600185200572,
-0.002785542281344533,
0.07242570072412491,
0.016719955950975418,
0.006242196075618267,
-0.016856975853443146,
-0.00003651122096925974,
-0.03051835298538208,
0.005914299748837948,
0.012003210373222828,
0.006725191604346037,
0.015260851010680199,
0.011086445301771164,
-0.00764190498739481,
-0.000955244991928339,
0.018657051026821136,
-0.010727104730904102,
-0.01670304499566555,
0.017883896827697754,
0.02173338457942009,
-0.010320259258151054,
-0.0024618315510451794,
0.017747612670063972,
0.00589640811085701,
-0.020938044413924217,
-0.016034698113799095,
-0.009061862714588642,
-0.030542578548192978,
0.02637401595711708,
-0.015076435171067715,
-0.024297943338751793,
0.006563833449035883,
-0.010121962055563927,
0.015790598466992378,
-0.00724448636174202,
-0.011276294477283955,
0.01884555071592331,
0.020731184631586075,
-0.021167408674955368,
0.020319459959864616,
0.013747034594416618,
-0.0047043184749782085,
0.02291230857372284,
-0.013213610276579857,
0.004497201647609472,
0.010769704356789589,
0.009475662373006344,
-0.019348816946148872,
-0.012199722230434418,
-0.009503727778792381,
-0.005588723346590996,
-0.00952350813895464,
-0.015899961814284325,
0.004128986969590187,
0.012342877686023712,
-0.005787139292806387,
-0.014740907587110996,
0.01224608812481165,
-0.005523619242012501,
-0.013102443888783455,
-0.003727746894583106,
0.0017925703432410955,
-0.021434858441352844,
-0.0052805631421506405,
-0.034414008259773254,
-0.00528739346191287,
0.006744778715074062,
-0.02716376818716526,
0.010626453906297684,
-0.01985315978527069,
0.014347349293529987,
0.020606914535164833,
-0.008314632810652256,
0.018635118380188942,
0.00817614421248436,
0.008325815200805664,
-0.027018645778298378,
-0.0012059577275067568,
-0.024683713912963867,
0.023508518934249878,
0.02548527717590332,
-0.04899892956018448,
-0.028044717386364937,
-0.015003617852926254,
-0.007013836409896612,
-0.03570915013551712,
0.0028068246319890022,
0.011107511818408966,
-0.0019433549605309963,
-0.07428738474845886,
0.00048832967877388,
0.000604092376306653,
-0.009331047534942627,
0.009535841643810272,
-0.0007793447002768517,
-0.011538635939359665,
-0.007916091941297054,
-0.01721782237291336,
0.001483439584262669,
-0.027979329228401184,
0.012322956696152687,
-0.0014339957851916552,
0.008351007476449013,
0.012929542921483517,
0.0021162049379199743,
-0.004979425109922886,
0.0003379814443178475,
-0.002221951726824045,
0.00016702222637832165,
-0.014416351914405823,
0.017754703760147095,
-0.020288938656449318,
-0.003147050505504012,
-0.010724634863436222,
-0.08122371137142181,
-0.018351959064602852,
0.000596190569922328,
0.006746822502464056,
-0.013312388211488724,
-0.0019456695299595594,
-0.009301421232521534,
-0.004269076511263847,
-0.01310507208108902,
-0.016685234382748604,
0.027089610695838928,
-0.0037148497067391872,
-0.0413808599114418,
0.001071851933375001,
0.030014771968126297,
-0.002547039184719324,
0.015766501426696777,
-0.02185414358973503,
-0.00879187136888504,
-0.0023377055767923594,
-0.002980451565235853,
-0.003157754661515355,
-0.00497237965464592,
-0.00176171213388443,
-0.012404022738337517,
-0.025852145627141,
-0.012977810576558113,
0.017857346683740616,
0.009598681703209877,
-0.0007698488188907504,
-0.012958342209458351,
-0.014138629660010338,
-0.007710205391049385,
0.009532690048217773,
-0.03455215319991112,
-0.01746748760342598,
0.00004536239430308342,
0.010595301166176796,
0.00457952544093132,
-0.0020677954889833927,
-0.006609586998820305,
0.03181719779968262,
-0.00005376152694225311,
-0.007102699019014835,
-0.006649139802902937,
0.02897460013628006,
0.005422511603683233,
-0.01435178518295288,
0.005826487205922604,
0.021009519696235657,
0.004564540460705757,
-0.013044117018580437,
0.028237124904990196,
0.002655954798683524,
0.052842624485492706,
-0.014416571706533432,
-0.014077695086598396,
-0.003426698036491871,
0.004742383491247892,
0.015844622626900673,
-0.011702294461429119,
0.01208716444671154,
-0.008658243343234062,
0.07106785476207733,
-0.024554550647735596,
0.013363361358642578,
0.015246366150677204,
-0.009286625310778618,
-0.0008975154487416148,
-0.014301624149084091,
-0.007632098160684109,
-0.012167437002062798,
-0.0031297544483095407,
-0.029032640159130096,
-0.0269735399633646,
0.03624139353632927,
0.010544428601861,
-0.014284861274063587,
-0.012712564319372177,
0.02449129894375801,
-0.0013767951168119907,
-0.01605287566781044,
0.01348789781332016,
0.035049084573984146,
0.02351001277565956,
-0.02681104466319084,
0.0033227684907615185,
0.029403965920209885,
0.004413486924022436,
-0.0019746003672480583,
-0.006459237542003393,
-0.019623959437012672,
-0.008338124491274357,
-0.022965380921959877,
0.013394616544246674,
0.0053397580049932,
-0.00996173731982708,
0.0025867605581879616,
-0.016127508133649826,
-0.0028867078945040703,
0.004939357750117779,
-0.0008509624749422073,
-0.01296019647270441,
-0.010334311053156853,
-0.011856433935463428,
-0.00573601434007287,
-0.00861707516014576,
0.01914263516664505,
0.0035150267649441957,
0.008675329387187958,
0.002855916041880846,
0.028945542871952057,
0.013331844471395016,
-0.006211616098880768,
0.0027233073487877846,
0.021857310086488724,
-0.002386190462857485,
0.006692781113088131,
0.014560246840119362,
-0.03243543580174446,
0.01660805195569992,
-0.0006216578185558319,
-0.0030443831346929073,
-0.0005237925797700882,
-0.03132450953125954,
-0.002550561912357807,
-0.026990484446287155,
0.0186239592730999,
-0.0069112638011574745,
0.018885275349020958,
-0.016328182071447372,
-0.014160683378577232,
0.013574517332017422,
-0.0008470779284834862,
-0.00040597980841994286,
0.007559687364846468,
-0.0040197717025876045,
0.005811074748635292,
-0.005995875224471092,
0.011965874582529068,
0.002891283482313156,
-0.004196988418698311,
0.0364803746342659,
-0.007299773395061493,
0.011026619002223015,
0.044390544295310974,
-0.011404679156839848,
0.007930856198072433,
0.006819817237555981,
-0.024758799001574516,
0.01287116575986147,
-0.00973124336451292,
0.007513930089771748,
0.033434756100177765,
0.010292638093233109,
0.005448485258966684,
0.011599808000028133,
0.009421057067811489,
0.03276287764310837,
-0.0175655297935009,
0.006044274196028709,
-0.016467098146677017,
0.01505456492304802,
0.010572617873549461,
0.014579894952476025,
-0.01209888607263565,
-0.0003591170534491539,
0.00848291628062725,
0.0012477196287363768,
-0.006876540370285511,
-0.002274490660056472,
0.016957422718405724,
0.01235599722713232,
-0.013721613213419914,
-0.021280530840158463,
0.016427379101514816,
-0.023747188970446587,
0.007193352561444044,
-0.006531583145260811,
-0.002882732544094324,
0.007599974516779184,
-0.009187242947518826,
-0.011632859706878662,
-0.013617921620607376,
0.009809979237616062,
0.021155038848519325,
0.007865128107368946,
0.045544564723968506,
-0.037961822003126144,
-0.009750358760356903,
-0.016972536221146584,
-0.020551491528749466,
-0.021517742425203323,
0.006210766267031431,
0.01804501563310623,
-0.012883351184427738,
0.000874590128660202,
0.004224769305437803,
-0.005026115104556084,
0.0008016182109713554,
0.01590602844953537,
-0.008788809180259705,
0.010023931972682476,
0.027463022619485855,
-0.009043289348483086,
-0.005211310461163521,
-0.012965678237378597,
0.011982010677456856,
-0.015235869213938713,
-0.014026987366378307,
0.008823554962873459,
0.007968760095536709,
0.018301907926797867,
0.0010842566844075918,
0.00806393288075924,
-0.005434282124042511,
-0.007751067169010639,
-0.0021727439016103745,
0.016072291880846024,
0.01654662750661373,
0.012989913113415241,
-0.012961329892277718,
0.01014700997620821,
0.011893726885318756,
-0.0008800292853266001,
-0.009797662496566772,
-0.005155161488801241,
0.007356155663728714,
0.003076000139117241,
0.009716639295220375,
-0.0022780876606702805,
-0.00413875188678503,
0.007990293204784393,
-0.012789535336196423,
0.0010916097089648247,
-0.016648273915052414,
0.023837119340896606,
-0.013078175485134125,
-0.012207702733576298,
0.014447497203946114,
-0.008506114594638348,
-0.010833283886313438,
0.023354697972536087,
0.01344047486782074,
0.014945968054234982,
-0.0012806677259504795,
-0.012216891162097454,
0.004463668912649155,
0.010559646412730217,
-0.0029572502244263887,
-0.0006471904926002026,
-0.007079050410538912,
0.018074598163366318,
-0.0020997179672122,
0.004807587713003159,
-0.016453232616186142,
0.012227203696966171,
-0.0027595742139965296,
0.007222243584692478,
-0.023136679083108902,
-0.0352492593228817,
0.015224771574139595,
0.0012966534122824669,
0.012227529659867287,
-0.006754272151738405
] | [
0.04117518290877342,
0.0518309660255909,
0.37155500054359436,
-0.2532486021518707,
-0.19796040654182434,
0.11796870082616806,
0.11855078488588333,
-0.2566680312156677,
-0.09554034471511841,
-0.03164435923099518,
0.2465212345123291,
0.7817578911781311,
-0.0728362575173378,
-0.12146783620119095,
0.3777395486831665,
0.9283944964408875,
0.2792237401008606,
-0.020966771990060806,
-0.18430759012699127,
-0.44353947043418884,
-0.18833278119564056,
-0.4994364380836487,
0.2382633239030838,
0.1605982780456543,
0.21773768961429596,
0.27096593379974365,
0.18476800620555878,
-0.022522982209920883,
-0.31417566537857056,
-0.22858385741710663,
-0.18807657063007355,
0.6803227663040161,
-0.2917254567146301,
-0.3807501494884491,
-0.03810405731201172,
0.39425456523895264,
0.04820474609732628,
0.39505329728126526,
0.08694687485694885,
-0.4655340313911438,
-0.18444539606571198,
-0.10994791984558105,
0.02248942106962204,
0.19315189123153687,
-0.3175406754016876,
-0.14958339929580688,
-1.6412935256958008,
-0.12065929919481277,
-0.5278986692428589,
0.3500180244445801,
-0.005864504724740982,
0.6218010783195496,
0.597507655620575,
0.22317969799041748,
-0.02896668203175068,
0.44427794218063354,
-0.06545253843069077,
-0.11495474725961685,
0.1068689376115799,
-0.6599596738815308,
0.28107893466949463,
0.3640364110469818,
-0.13471582531929016,
0.5375500321388245,
-0.09920387715101242,
0.2523229122161865,
-0.45697373151779175,
-0.2569446563720703,
-0.3519253432750702,
-0.1505163609981537,
0.22737088799476624,
0.1600477248430252,
-0.21492478251457214,
0.2798708975315094,
-0.15358684957027435,
0.30279412865638733,
-0.29526275396347046,
-0.12159422039985657,
0.16468705236911774,
0.18038561940193176,
0.23325830698013306,
-0.09490569680929184,
0.6805384159088135,
-0.5529180765151978,
0.4688103497028351,
0.5344447493553162,
-0.11582306772470474,
0.4158860445022583,
0.25494855642318726,
0.003066013101488352,
0.19081175327301025,
-0.25604045391082764,
0.2704046368598938,
0.4743371605873108,
0.3352890908718109,
0.058787912130355835,
0.2700275778770447,
0.01731914095580578,
0.010950027033686638,
-0.04776661470532417,
0.05140146613121033,
-0.14329184591770172,
-0.06839998811483383,
-0.228386789560318,
-0.42544639110565186,
-0.30182427167892456,
-0.3341161012649536,
-0.42496010661125183,
-0.5695337653160095,
0.38466835021972656,
-0.6278878450393677,
0.6292707920074463,
0.11372974514961243,
-0.38922715187072754,
-0.15693816542625427,
-0.1713663786649704,
0.3448285460472107,
0.040367186069488525,
-0.015055220574140549,
0.31045329570770264,
-0.23264507949352264,
0.5328516960144043,
0.3030848503112793,
0.5005210041999817,
0.3174274265766144,
0.35627081990242004,
0.8345885872840881,
0.29301100969314575,
-0.4521755576133728,
0.007312730886042118,
0.2902796268463135,
0.6500670909881592,
0.03373042121529579,
0.06529027223587036,
-0.04801062121987343,
0.0845370888710022,
0.4102528393268585,
-0.12494257837533951,
0.6244143843650818,
0.23089899122714996,
-0.26177898049354553,
-0.681020200252533,
-0.6729511618614197,
-0.6438189744949341,
0.1453598588705063,
-0.3738887906074524,
0.08286052942276001,
-0.023859474807977676,
-0.00723965372890234,
-0.17438443005084991,
0.03612996265292168,
0.11239666491746902,
-0.39977920055389404,
-0.5172699093818665,
0.0584159791469574,
0.3263385593891144,
-0.5879882574081421,
-0.050507642328739166,
-0.4337328374385834,
-0.2107105553150177,
0.23652639985084534,
0.5041587948799133,
-0.6122345924377441,
-0.026150381192564964,
0.19877944886684418,
-0.3617301285266876,
-0.3427928388118744,
0.02616102248430252,
0.16994695365428925,
0.008545521646738052,
-0.32940641045570374,
-0.21763592958450317,
0.040820538997650146,
-0.3642767667770386,
-0.47109630703926086,
0.45981529355049133,
0.8442091345787048,
0.3024452030658722,
0.23050545156002045,
0.1333044171333313,
-0.6152737736701965,
0.0035776738077402115,
0.11251166462898254,
-0.8045087456703186,
0.3360344469547272,
-0.023161541670560837,
0.6230401396751404,
-0.22076930105686188,
0.21084710955619812,
0.3312937319278717,
-0.4741087853908539,
-0.5537005662918091,
0.38913673162460327,
-0.7722883820533752,
1.5033702850341797,
-0.3869906961917877,
-0.26839542388916016,
1.173405647277832,
-0.013916382566094398,
0.02232377417385578,
0.39173880219459534,
0.6158046722412109,
0.3901141881942749,
-0.21871572732925415,
-0.751872181892395,
-0.2374202013015747,
-0.30531200766563416,
-0.32035747170448303,
-0.4954744875431061,
0.16678857803344727,
0.3255935609340668,
-0.21134164929389954,
-0.276589959859848,
-0.4292738437652588,
-0.0487554594874382,
0.18574856221675873,
-0.19435328245162964,
0.3971651494503021,
0.015206248499453068,
-0.43862682580947876,
0.45973339676856995,
-0.45864760875701904,
0.22478574514389038,
0.3959042429924011,
-0.2839350700378418,
0.4978752136230469,
-0.21615232527256012,
0.1100882738828659,
0.8883887529373169,
-1.3606244325637817,
0.3346222937107086,
-0.10619716346263885,
0.03528158739209175,
-0.4653945863246918,
-0.20167472958564758,
0.2021455317735672,
-0.09794529527425766,
-0.5711055994033813,
-0.18528127670288086,
0.07591459900140762,
0.2764430344104767,
0.07556280493736267,
-0.6599239706993103,
0.25793778896331787,
0.3088105320930481,
-0.3998350501060486,
-0.1507982462644577,
0.36321142315864563,
-0.4933558404445648,
0.13418054580688477,
0.21396848559379578,
0.15650281310081482,
-0.06094183027744293,
0.25374338030815125,
0.40017959475517273,
0.08443621546030045,
-0.24100355803966522,
-0.005227586720138788,
0.15847869217395782,
-0.27161380648612976,
0.060040462762117386,
0.08179540932178497,
0.15293246507644653,
-0.17227119207382202,
0.028342338278889656,
-0.694470226764679,
-0.12554003298282623,
-0.35467860102653503,
0.19962447881698608,
0.6277658939361572,
0.13449332118034363,
0.46449121832847595,
-0.422561377286911,
0.35579225420951843,
-0.012823821045458317,
-0.8370760679244995,
0.23233580589294434,
0.7267996668815613,
-0.8364791870117188,
-0.18867036700248718,
-0.03505346551537514,
-0.19831177592277527,
0.7752962708473206,
-0.3900606632232666,
-0.1033748984336853,
-0.12577302753925323,
-0.2954244911670685,
-0.03585972636938095,
-0.37229880690574646,
0.11254353821277618,
-0.34111204743385315,
0.3561955392360687,
-0.5022144913673401,
-0.2604551911354065,
0.49711453914642334,
0.2005072832107544,
0.1479554921388626,
0.4548781216144562,
0.307574599981308,
-0.14602310955524445,
-0.4816034734249115,
0.39458537101745605,
0.1938687115907669,
-0.2941962480545044,
-0.015057411976158619,
-0.049756839871406555,
-0.3056032061576843,
-0.169381245970726,
-6.0451483726501465,
-0.13933078944683075,
-0.581948459148407,
-0.35168835520744324,
-0.14139334857463837,
0.3742903769016266,
0.9110699892044067,
0.15315283834934235,
0.10100461542606354,
-0.059826355427503586,
0.3463316857814789,
0.5098437070846558,
0.029925096780061722,
0.0783868357539177,
0.19739031791687012,
0.378705769777298,
0.12503257393836975,
0.19480957090854645,
-0.22928926348686218,
0.26818403601646423,
0.3213954567909241,
-0.20338869094848633,
0.20613162219524384,
0.7230305671691895,
0.12014712393283844,
0.18432831764221191,
-1.0687350034713745,
0.3897879421710968,
0.09084025770425797,
-0.25769340991973877,
0.35313090682029724,
-0.39285483956336975,
-0.128594771027565,
-0.09394025057554245,
0.3568313419818878,
0.028246711939573288,
0.33118224143981934,
0.1952616572380066,
0.08910217881202698,
-0.48367542028427124,
0.12219804525375366,
0.31003400683403015,
-0.04400501400232315,
-0.4654783606529236,
-0.2111494541168213,
-0.3614639937877655,
0.1447935849428177,
0.5946927666664124,
-0.27213922142982483,
0.6193174123764038,
-0.10446466505527496,
-0.4558844268321991,
0.10056992620229721,
0.524610698223114,
0.21737618744373322,
-0.1731465756893158,
0.31826144456863403,
0.4611549377441406,
-0.27281659841537476,
0.05075068771839142,
0.08228307962417603,
-0.34637725353240967,
-0.6753787398338318,
-1.1287763118743896,
-0.2930312752723694,
0.35223427414894104,
-0.7328128218650818,
-0.2455299198627472,
0.3116113543510437,
0.6183488965034485,
-0.24888572096824646,
-0.024748438969254494,
0.23698671162128448,
-0.45996108651161194,
-0.02690568007528782,
-0.6566098928451538,
0.4663448631763458,
0.0268753319978714,
-0.20607204735279083,
0.08740746229887009,
-0.09925776720046997,
-0.17797230184078217,
0.326790452003479,
-0.06212633475661278,
0.09657171368598938,
-0.0089134331792593,
-0.3478200137615204,
-0.46951794624328613,
-0.05197165906429291,
0.36233052611351013,
0.2759871184825897,
-0.22477848827838898,
-0.1514841765165329,
0.49589645862579346,
0.18884840607643127,
0.2080138772726059,
0.6412592530250549,
0.3081355392932892,
0.5180342793464661,
-0.46612516045570374,
0.7087505459785461,
-0.16558024287223816,
0.2659245729446411,
-0.634810209274292,
0.009416780434548855,
0.13818010687828064,
-0.7030720710754395,
-0.04336624592542648,
1.0136926174163818,
-0.6122327446937561,
-0.007134147919714451,
0.09753511101007462,
0.10093723982572556,
-0.010463954880833626,
0.09930305927991867,
-0.03155660256743431,
0.304328590631485,
-0.006725308485329151,
0.42415669560432434,
-0.4625883400440216,
0.1759343296289444,
0.11330658942461014,
-0.03823088854551315,
0.04222147539258003,
0.2598642110824585,
-0.20543496310710907,
0.3536360263824463,
0.6812132596969604,
-0.5894718766212463,
0.06720055639743805,
0.19661395251750946,
0.17705215513706207,
0.04397841915488243,
0.4415420591831207,
0.2678973078727722,
-0.6859082579612732,
-0.47540897130966187,
0.12740889191627502,
0.30167847871780396,
0.13018245995044708,
0.2475241720676422,
-0.2802816331386566,
-0.3293459713459015,
-0.13516736030578613,
0.39282625913619995,
-0.17557556927204132,
-0.18161310255527496,
-0.22672443091869354,
-0.15359149873256683,
0.3975194990634918,
0.1915307193994522,
-0.021617023274302483,
0.021269280463457108,
-0.1432315856218338,
-0.33586591482162476,
0.32164275646209717,
0.263504296541214,
-0.08706030994653702,
0.029151758179068565,
-0.7682082056999207,
0.18227306008338928,
0.26821741461753845,
-1.2169235944747925,
-0.43350791931152344,
-0.15141673386096954,
-0.21668198704719543,
-0.042152658104896545,
-0.20714910328388214,
-0.007740289904177189,
0.27283456921577454,
0.16351844370365143,
-0.5083863139152527,
-0.24184168875217438,
-0.23301158845424652,
-0.003251537913456559,
0.3521764278411865,
-0.17706666886806488,
0.23049914836883545,
0.1111665889620781,
0.34517449140548706,
0.5582889914512634,
-0.22892212867736816,
0.07821428775787354,
-0.26333433389663696,
0.6335293650627136,
-0.147467702627182,
0.0354936383664608,
-0.4304361045360565,
-0.16196033358573914,
-0.11558005213737488,
0.09676436334848404,
0.09663412719964981,
0.6221731305122375,
-0.04640382528305054,
-0.13764511048793793,
-0.5495086908340454,
0.00003608837505453266,
0.047500815242528915,
0.06426854431629181,
-0.09739390015602112,
0.07275742292404175,
0.5708395838737488,
-0.24716763198375702,
0.5527163743972778,
0.0010013142600655556,
-0.24492375552654266,
-0.2244749665260315,
-0.41367191076278687,
-0.5423364639282227,
0.02291169762611389,
-0.06276965886354446,
-0.24556979537010193,
0.3297175467014313,
0.48688891530036926,
-0.3115023374557495,
-0.010708416812121868,
0.06639385968446732,
-0.3020729422569275,
-0.47504037618637085,
0.12347029149532318,
0.29693323373794556,
-0.0011011397000402212,
-0.33647677302360535,
0.4197145700454712,
-0.4511280655860901,
-0.36012014746665955,
0.582848072052002,
-0.7387747168540955,
0.0008043074631132185,
0.19415372610092163,
-0.4769693911075592,
0.20760267972946167,
0.10902729630470276,
-0.08098804205656052,
-0.46639734506607056,
0.05018710345029831,
-0.4723891019821167,
-0.0581725649535656,
0.25184687972068787,
0.25288960337638855,
0.15686358511447906,
0.5759749412536621,
-0.17916153371334076,
-0.3520324230194092,
0.16312578320503235,
0.13648419082164764,
0.6435289978981018,
-0.5219215154647827,
-0.37459301948547363,
0.2029373049736023,
0.13518355786800385,
-0.27480974793434143,
-0.263304203748703,
-0.2246542125940323,
0.28729137778282166,
0.20605286955833435,
-0.30034056305885315,
0.003050781786441803,
-0.3018789291381836,
0.2855111360549927,
0.14713704586029053,
-0.19330653548240662,
-0.39755308628082275,
-0.3811555802822113,
0.14187756180763245,
0.3056996464729309,
-0.21251744031906128,
-0.5588280558586121,
0.126339390873909,
-0.6421123147010803,
0.2214478999376297,
0.3677026331424713,
0.6369336247444153,
0.23391807079315186,
0.42652425169944763,
-0.23523364961147308,
-0.02449473924934864,
0.02799459733068943,
0.8526855111122131,
-0.06102937087416649,
-0.2742486894130707,
-0.4549160897731781,
0.5746877193450928,
-0.08524350821971893,
0.5398929715156555,
-0.5008128881454468,
0.15066295862197876,
-0.33570995926856995,
-0.5409094095230103,
-0.7181040048599243,
-0.046378038823604584,
0.601197361946106,
-0.4917430281639099,
0.09185688197612762,
-0.1849886029958725,
0.29652640223503113,
0.06897585839033127,
0.22602050006389618,
0.164826899766922,
-0.5324249267578125,
-0.5808225274085999,
0.45599058270454407,
0.567631185054779,
-0.6870341897010803,
0.03267029672861099,
-0.06624206900596619,
0.4265918433666229,
0.23698394000530243,
0.017389358952641487,
-0.2671647369861603,
0.5530598759651184,
-0.1499873846769333,
0.2124016433954239,
0.35805603861808777,
0.15210814774036407,
-0.26007625460624695,
-0.32733649015426636,
-0.0408126600086689,
0.5930913090705872,
0.3448185920715332,
0.2041786015033722,
0.7934813499450684,
0.851505696773529,
-0.08539030700922012,
-0.43646278977394104,
0.4650287628173828,
-0.3156712055206299,
0.515055239200592,
0.09463255852460861,
0.08811091631650925,
0.21824920177459717,
0.4229307770729065,
-0.020876819267868996,
0.3046601116657257,
-0.32447221875190735,
0.3953697681427002,
0.1443406343460083,
-0.16691693663597107,
-0.41058847308158875,
0.11414065212011337,
0.640784502029419,
0.5347832441329956,
0.20641803741455078,
-0.0690305307507515,
0.17639707028865814,
0.43996649980545044,
-0.04736349731683731,
0.20174463093280792,
0.19146333634853363,
-0.04651138558983803,
0.10897363722324371,
-0.12435121834278107,
-0.08749181777238846,
0.03479486703872681,
-0.14853040874004364,
0.17675939202308655,
0.6844374537467957,
-0.3157835304737091,
-0.6187936663627625,
0.332523912191391,
-0.5788731575012207,
0.3684741258621216,
-0.09326693415641785,
0.057924535125494,
-0.20444557070732117,
-0.12511484324932098,
0.606564462184906,
0.05018999055027962,
0.4437865614891052,
0.0811353474855423,
-0.07187677174806595,
0.42983415722846985,
-0.6358281373977661,
0.7146730422973633,
-0.2155744880437851,
-0.9969696402549744,
0.37594303488731384,
0.22616702318191528,
0.10006341338157654,
0.3699705898761749,
-0.3700830042362213,
-0.2532491385936737,
0.17540793120861053,
-0.4527377188205719,
0.22576890885829926,
-0.3393017649650574,
-0.30744239687919617,
0.015979908406734467,
0.47996851801872253,
0.07141296565532684,
-0.2579739987850189,
-0.6410452127456665,
-0.16111662983894348,
-0.3055022656917572,
-0.4045974016189575,
-0.2846907675266266,
-0.024425726383924484,
0.38793760538101196,
-0.04649769142270088,
-0.03701252490282059,
-0.4628821909427643,
0.13579624891281128,
-0.21571744978427887,
0.23205570876598358,
-0.39563605189323425,
0.3747725188732147,
-0.3805822432041168,
0.17633649706840515,
-0.45860937237739563,
0.207257941365242,
0.32784906029701233,
0.2787693440914154,
-0.4146293103694916,
0.18759728968143463,
-0.48794543743133545,
-0.054427411407232285,
0.3229367733001709,
-0.27231529355049133,
0.32240208983421326,
0.11241544038057327,
-0.5874649882316589,
-0.2857266664505005,
0.30451691150665283,
-0.08261283487081528,
-0.25103116035461426,
-0.036920636892318726,
0.26360270380973816,
0.48691526055336,
0.10051044821739197,
0.5752020478248596,
-0.14657162129878998,
-0.09987052530050278,
-0.548564612865448,
0.18167351186275482,
-0.4016525447368622,
-0.002732079941779375,
-0.5099443197250366,
0.30918219685554504,
0.47305136919021606,
-0.5901073813438416,
-0.2725691795349121,
-0.020921749994158745,
-0.19114167988300323,
-0.0671277791261673,
0.19036240875720978,
0.3913516402244568,
0.13240857422351837,
-0.2500699460506439,
-0.8326250314712524,
0.47447440028190613,
-0.2964366674423218,
-0.8289250731468201,
0.008291816338896751,
-0.39848339557647705,
-0.2744584083557129,
-0.41488102078437805,
-0.4808116555213928,
-0.5328361392021179,
-0.2987389862537384,
-0.32865121960639954
] |
In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Accordingly, it is important to update these guidelines for monitoring autophagy in different organisms. Various reviews have described the range of assays that have been used for this purpose. Nevertheless, there continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes. A key point that needs to be emphasized is that there is a difference between measurements that monitor the numbers or volume of autophagic elements (e.g., autophagosomes or autolysosomes) at any stage of the autophagic process vs. those that measure flux through the autophagy pathway (i.e., the complete process); thus, a block in macroautophagy that results in autophagosome accumulation needs to be differentiated from stimuli that result in increased autophagic activity, defined as increased autophagy induction coupled with increased delivery to, and degradation within, lysosomes (in most higher eukaryotes and some protists such as Dictyostelium) or the vacuole (in plants and fungi). In other words, it is especially important that investigators new to the field understand that the appearance of more autophagosomes does not necessarily equate with more autophagy. In fact, in many cases, autophagosomes accumulate because of a block in trafficking to lysosomes without a concomitant change in autophagosome biogenesis, whereas an increase in autolysosomes may reflect a reduction in degradative activity. Here, we present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes. These guidelines are not meant to be a formulaic set of rules, because the appropriate assays depend in part on the question being asked and the system being used. In addition, we emphasize that no individual assay is guaranteed to be the most appropriate one in every situation, and we strongly recommend the use of multiple assays to monitor autophagy. In these guidelines, we consider these various methods of assessing autophagy and what information can, or cannot, be obtained from them. Finally, by discussing the merits and limits of particular autophagy assays, we hope to encourage technical innovation in the field. | [
0.017521880567073822,
0.014501410536468029,
-0.015058686025440693,
0.011847374029457569,
0.0005104690790176392,
0.005191555712372065,
0.007268997840583324,
0.00243100943043828,
-0.020972946658730507,
-0.014005433768033981,
0.0004681635182350874,
0.01176746841520071,
-0.009630155749619007,
0.012347210198640823,
-0.000289055984467268,
0.005361934658139944,
-0.034319572150707245,
-0.015388255007565022,
0.005058306735008955,
0.003053263993933797,
-0.01069478690624237,
0.0028629822190850973,
0.009731974452733994,
-0.002281642984598875,
-0.0045879497192800045,
-0.000705980695784092,
-0.006247741170227528,
-0.015720373019576073,
0.010807372629642487,
-0.0044471267610788345,
0.015802867710590363,
-0.00013441825285553932,
-0.007074242457747459,
-0.025990692898631096,
0.014027965255081654,
0.0158469770103693,
-0.0008645576308481395,
0.017566483467817307,
-0.004763226956129074,
-0.002908153925091028,
-0.004997562617063522,
-0.005848991684615612,
0.006129544693976641,
0.01891005039215088,
-0.00916936993598938,
-0.002390554640442133,
-0.005819546990096569,
0.002553346799686551,
-0.023137178272008896,
0.013836870901286602,
-0.013712606392800808,
0.00601053424179554,
-0.003983302041888237,
0.007660265546292067,
-0.005943431053310633,
-0.003642977448180318,
0.019695449620485306,
0.0146266994997859,
-0.00790307205170393,
0.010988081805408001,
0.003760016756132245,
0.0038207522593438625,
0.02094314619898796,
0.0023400699719786644,
-0.01888468489050865,
-0.06725256890058517,
-0.011608285829424858,
0.03258226066827774,
0.009671183302998543,
-0.009692990221083164,
-0.0006548557430505753,
0.010739888064563274,
0.004920437932014465,
0.0031102511566132307,
0.02451411262154579,
0.014625000767409801,
0.009247281588613987,
0.015640541911125183,
-0.004906023852527142,
-0.013264428824186325,
0.0018901480361819267,
-0.029003720730543137,
0.005725956987589598,
0.011571601033210754,
0.007812672294676304,
0.015717051923274994,
-0.0027843350544571877,
0.02186517044901848,
0.013765526004135609,
0.024543721228837967,
0.006102954503148794,
-0.02502356469631195,
-0.007218056824058294,
-0.012846103869378567,
0.009189704433083534,
0.016116680577397346,
-0.03264894336462021,
-0.007081386633217335,
-0.013023659586906433,
-0.020655440166592598,
-0.001998055726289749,
0.02418883889913559,
0.023349344730377197,
0.010638679377734661,
0.01870650239288807,
0.012594593688845634,
0.0027343672700226307,
0.005727584473788738,
-0.0018922784365713596,
0.0018238893244415522,
0.003257454838603735,
0.011416045017540455,
-0.013689502142369747,
0.006557703949511051,
-0.0029910122975707054,
-0.014515858143568039,
-0.011246658861637115,
-0.006691713817417622,
0.00748767564073205,
0.0006921361200511456,
0.014946868643164635,
-0.008709755726158619,
0.011864992789924145,
-0.006499942857772112,
-0.0015023202868178487,
-0.018864624202251434,
-0.01091047190129757,
-0.008251405321061611,
-0.009869943372905254,
-0.001588151091709733,
-0.00712546007707715,
-0.009638440795242786,
0.025060579180717468,
0.0036421227268874645,
0.03572826832532883,
0.0023094038479030132,
-0.021490521728992462,
-0.005772361531853676,
0.008366874419152737,
-0.022164413705468178,
-0.0003937241854146123,
0.004634245298802853,
0.0017673755064606667,
0.015138539485633373,
0.03901594132184982,
0.0063621364533901215,
-0.0052131349220871925,
-0.0042144013568758965,
0.008155899122357368,
-0.022820990532636642,
0.024119919165968895,
-0.003842107020318508,
0.004621818661689758,
-0.014850831590592861,
0.002233866136521101,
-0.017560238018631935,
-0.004390850197523832,
-0.014939779415726662,
-0.0032198396511375904,
0.006204554345458746,
0.018764104694128036,
-0.003328219521790743,
0.008890198543667793,
0.008477135561406612,
0.004016154911369085,
0.009639618918299675,
-0.00869919266551733,
0.0024593514390289783,
-0.013279427774250507,
-0.002962919883430004,
-0.009040075354278088,
0.0037109770346432924,
-0.019690383225679398,
0.011197855696082115,
-0.008556926622986794,
0.0027910592034459114,
-0.0006848748307675123,
0.00606275862082839,
-0.010767793282866478,
0.06718043982982635,
0.03162889927625656,
0.02188512496650219,
-0.012751325033605099,
0.022926753386855125,
0.011901719495654106,
0.004637232981622219,
-0.006286549381911755,
-0.007146178744733334,
-0.0006084181368350983,
0.007923206314444542,
-0.01577131450176239,
0.015884019434452057,
0.009426653385162354,
0.0015941858291625977,
0.015115453861653805,
0.0028216652572155,
0.01753935031592846,
-0.003954347223043442,
-0.001346970209851861,
-0.015622745268046856,
0.007768059615045786,
-0.00072462297976017,
0.0318676233291626,
-0.007857918739318848,
-0.02514292672276497,
0.007826759479939938,
0.012051356956362724,
-0.040059663355350494,
-0.00724385492503643,
-0.0004228283651173115,
0.016860317438840866,
-0.01348897349089384,
-0.000550783472135663,
-0.013484282419085503,
-0.01210876926779747,
0.008162682875990868,
0.006946174427866936,
-0.024480052292346954,
-0.007931559346616268,
-0.019158516079187393,
0.0011755793821066618,
0.0044502029195427895,
0.021310921758413315,
0.013430607505142689,
-0.011607016436755657,
0.0038258905988186598,
-0.006344374734908342,
0.012953342869877815,
0.002587464638054371,
-0.004640632309019566,
-0.011230888776481152,
0.02018367499113083,
-0.008479740470647812,
-0.007337280549108982,
0.03342629596590996,
-0.009484117850661278,
0.008587092161178589,
0.0032967166043817997,
0.009755968116223812,
-0.0054027969017624855,
-0.014708689413964748,
0.012113191187381744,
0.039494674652814865,
-0.016261490061879158,
0.014656961895525455,
0.01042383536696434,
0.002731801476329565,
0.01944391243159771,
0.027776265516877174,
0.0031825737096369267,
0.0010681059211492538,
0.014382818713784218,
0.02556896209716797,
0.010772082023322582,
0.01037302054464817,
-0.009697875939309597,
0.010016221553087234,
-0.01265589240938425,
0.022129375487565994,
-0.022341161966323853,
-0.00036664039362221956,
0.0017274550627917051,
-0.002036122605204582,
-0.0041249096393585205,
0.02573864534497261,
-0.0027795792557299137,
0.03328469395637512,
-0.010841267183423042,
0.010237153619527817,
-0.010882082395255566,
0.002052363706752658,
-0.006429723929613829,
-0.0032265589106827974,
-0.08135518431663513,
-0.011171652004122734,
0.0024722302332520485,
0.0041538989171385765,
0.007151463069021702,
0.008956065401434898,
0.011241170577704906,
-0.003473181976005435,
-0.006755013018846512,
-0.01902347058057785,
0.006269948557019234,
0.02234772965312004,
-0.007403142750263214,
-0.021986601874232292,
0.005831885151565075,
0.002641997765749693,
0.01191179733723402,
-0.008794489316642284,
-0.0031002461910247803,
0.013116387650370598,
0.0099007748067379,
-0.011589153669774532,
0.0006261584348976612,
0.001230478985235095,
0.005232842639088631,
-0.022825472056865692,
0.023162050172686577,
0.012497754767537117,
-0.0009322542464360595,
0.006763193756341934,
0.009876929223537445,
0.0009170509874820709,
-0.0021391306072473526,
0.012091163545846939,
0.017385773360729218,
0.022049639374017715,
0.004009135998785496,
-0.0003135360311716795,
-0.015206374228000641,
0.008256983011960983,
0.003610991407185793,
0.0015661270590499043,
0.006412772461771965,
-0.0023329094983637333,
0.002686835592612624,
-0.007402733899652958,
-0.001425186637789011,
0.024289201945066452,
0.01708056405186653,
-0.007277634460479021,
0.012455335818231106,
-0.01263696700334549,
-0.0018128427909687161,
0.020892433822155,
-0.011706500314176083,
0.006017676088958979,
-0.01867470145225525,
0.01054280437529087,
-0.012536946684122086,
0.0020355849992483854,
0.023630501702427864,
-0.019143283367156982,
-0.008118394762277603,
0.019296664744615555,
-0.01112766470760107,
0.00818471796810627,
0.00929044745862484,
0.031527310609817505,
-0.004679195582866669,
-0.001842564670369029,
0.0167107954621315,
0.010155975818634033,
-0.0021107890643179417,
-0.0010661495616659522,
0.0015167417004704475,
-0.016691679134964943,
-0.018345380201935768,
-0.003503259504213929,
0.017145568504929543,
-0.006828005425632,
-0.0011226774659007788,
0.006465940270572901,
-0.0011595068499445915,
-0.0108173293992877,
-0.008158368989825249,
-0.009427977725863457,
0.008905265480279922,
0.00840448122471571,
0.008498873561620712,
-0.01577833667397499,
0.0014740126207470894,
0.0038097556680440903,
-0.011496220715343952,
0.0067219482734799385,
0.00525280786678195,
-0.0010957891354337335,
0.023921864107251167,
0.013790160417556763,
0.0224398672580719,
0.00826618354767561,
0.003088733647018671,
0.006325733382254839,
0.0002734593581408262,
-0.016339126974344254,
-0.016070207580924034,
0.009311167523264885,
-0.025345688685774803,
0.018360765650868416,
0.012425475753843784,
-0.005071923136711121,
0.016189660876989365,
-0.005062985699623823,
-0.008565079420804977,
0.027753612026572227,
0.005540070123970509,
0.0107935331761837,
-0.006817609071731567,
0.005832489579916,
0.07299023866653442,
0.0009628167608752847,
0.008462095633149147,
-0.01549092773348093,
-0.0058519188314676285,
-0.030132289975881577,
-0.010754109360277653,
0.003047590609639883,
0.027248956263065338,
-0.002423974685370922,
0.010578973218798637,
0.002217336092144251,
-0.00027777161449193954,
0.01990550383925438,
0.005559052340686321,
-0.0010755639523267746,
0.002261948538944125,
-0.027854125946760178,
-0.015698745846748352,
-0.025565437972545624,
-0.02135237492620945,
0.0065702758729457855,
-0.00337921641767025,
-0.006298315245658159,
0.017021123319864273,
-0.009343354031443596,
-0.017371201887726784,
-0.012535730376839638,
-0.003313909051939845,
-0.0033581608440726995,
0.009770781733095646,
0.013720180839300156,
-0.0036743551027029753,
0.0012933043763041496,
0.015569848008453846,
0.030466487631201744,
0.015504986979067326,
-0.0009311994072049856,
0.003978982102125883,
0.0075574154034256935,
0.017500493675470352,
-0.008416591212153435,
-0.015628069639205933,
0.0021017056424170732,
0.017045583575963974,
0.0003773572389036417,
0.007473137229681015,
-0.005194197874516249,
-0.012334502302110195,
0.0036296253092586994,
-0.01049655769020319,
0.009427613578736782,
0.010237890295684338,
0.0008684946224093437,
0.016845371574163437,
0.004524724557995796,
0.026097454130649567,
-0.0054834987968206406,
0.008907423354685307,
-0.02210436575114727,
-0.003320912830531597,
0.009533541277050972,
0.0021163662895560265,
-0.009359253570437431,
-0.009343786165118217,
-0.004747713916003704,
0.016926359385252,
-0.002998882671818137,
0.02802199125289917,
-0.006767331622540951,
0.01822095736861229,
-0.02624901384115219,
-0.008818980306386948,
-0.009113380685448647,
0.0017015121411532164,
-0.03963763639330864,
-0.00703632365912199,
-0.021102450788021088,
0.0047708963975310326,
-0.0027517108246684074,
0.007645750418305397,
0.025819793343544006,
-0.015183338895440102,
-0.012769262306392193,
0.008755255490541458,
-0.015069610439240932,
-0.01422239001840353,
-0.07492409646511078,
-0.015293018892407417,
-0.006533066742122173,
-0.0006556886364705861,
-0.011248081922531128,
0.005369795951992273,
-0.02930559776723385,
0.010070445947349072,
0.02281343936920166,
-0.002317197620868683,
0.012408977374434471,
-0.003304172307252884,
0.0008771911961957812,
0.006227798759937286,
0.009952541440725327,
0.000477838097140193,
-0.01281934604048729,
-0.005717433523386717,
-0.006592730060219765,
0.01629503071308136,
0.025341399013996124,
-0.004958474542945623,
0.01991366595029831,
-0.014138266444206238,
-0.006869812496006489,
-0.08161672204732895,
-0.0007223966531455517,
0.008913598023355007,
0.009648475795984268,
-0.01289987750351429,
0.015713218599557877,
0.011986920610070229,
-0.018405351787805557,
0.021037336438894272,
-0.015642497688531876,
-0.008453227579593658,
-0.0006916164420545101,
0.013864722102880478,
-0.0022028617095202208,
0.0031664802227169275,
0.0021393185015767813,
0.011473847553133965,
0.005339757539331913,
-0.02071053721010685,
-0.013508514501154423,
0.004389186855405569,
0.012491777539253235,
-0.004947716370224953,
-0.0003205811372026801,
-0.009665249846875668,
0.008522111922502518,
-0.013501076959073544,
0.010115242563188076,
0.013795414939522743,
0.011742631904780865,
0.011005318723618984,
0.018500227481126785,
-0.008347501046955585,
-0.00566207617521286,
-0.013574696145951748,
-0.013243529014289379,
-0.02966455928981304,
-0.005094442516565323,
-0.024265233427286148,
-0.021740049123764038,
-0.0054817781783640385,
-0.00448745209723711,
-0.022714976221323013,
-0.0231434628367424,
0.0024837087839841843,
-0.007139707915484905,
0.003069646656513214,
-0.0052644419483840466,
0.002454201690852642,
0.013282287865877151,
0.011762742884457111,
-0.00261749979108572,
0.017717085778713226,
0.0023649847134947777,
0.0014720617327839136,
0.023975564166903496,
-0.001829091226682067,
0.013233374804258347,
-0.013993704691529274,
0.015301268547773361,
0.0033442359417676926,
0.020627766847610474,
0.006872616708278656,
0.07218343019485474,
0.003814796917140484,
-0.004425310529768467,
-0.0022854250855743885,
-0.014287491329014301,
-0.004403695929795504,
0.009945489466190338,
-0.003982190042734146,
-0.00014953338541090488,
-0.008899912238121033,
0.000051435548812150955,
-0.013359250500798225,
-0.011448062025010586,
0.003055386710911989,
-0.017347702756524086,
0.017201699316501617,
-0.033368587493896484,
0.027207477018237114,
0.012403161264955997,
-0.018548633903265,
-0.022204512730240822,
0.000409495085477829,
-0.036751389503479004,
-0.0020024997647851706,
-0.004031976219266653,
-0.0056618289090693,
-0.024031788110733032,
0.013738198205828667,
-0.01656000129878521,
-0.023881662636995316,
-0.022938279435038567,
0.015506885945796967,
0.0018073543906211853,
0.01629612222313881,
0.022385280579328537,
0.011959301307797432,
0.005680551752448082,
0.0006490857340395451,
-0.009852186776697636,
-0.021554572507739067,
0.013371887616813183,
0.0033446771558374166,
0.004247413482517004,
-0.003027919214218855,
0.01183934323489666,
-0.0018396545201539993,
-0.010514950379729271,
0.01940983533859253,
-0.00461332593113184,
0.013646714389324188,
-0.010400470346212387,
0.005417065229266882,
0.004950933624058962,
-0.0026450040750205517,
-0.006501493975520134,
-0.0064567262306809425,
-0.00029346859082579613,
0.021918892860412598,
0.005446966737508774,
-0.025981642305850983,
0.015906620770692825,
-0.004584728740155697,
-0.021651286631822586,
-0.006624314002692699,
0.003549960907548666,
0.002193349413573742,
0.02060527913272381,
-0.020545989274978638,
-0.011518840678036213,
0.01281827688217163,
-0.0007567978464066982,
0.016357021406292915,
-0.003180712927132845,
0.0076980991289019585,
0.008813004940748215,
-0.002022423082962632,
0.0022354358807206154,
-0.009087486192584038,
0.015201426111161709,
0.0005087049212306738,
-0.014373330399394035,
0.025730784982442856,
0.031903404742479324,
-0.01146920956671238,
-0.029370754957199097,
0.015762878581881523,
-0.0009682103991508484,
-0.006116093136370182,
-0.005406912881880999,
0.009662210941314697,
-0.0013577188365161419,
0.0072677237913012505,
-0.009172622114419937,
-0.011005468666553497,
0.0033913294319063425,
0.03337709233164787,
0.004587964620441198,
0.012327976524829865,
0.009740941226482391,
-0.006902286782860756,
-0.016987306997179985,
-0.000878787599503994,
0.009360956028103828,
-0.005142660345882177,
-0.031303755939006805,
-0.013047921471297741,
0.008771101012825966,
0.028992602601647377,
0.008331872522830963,
0.002119726501405239,
0.0012605898082256317,
0.010794956237077713,
0.014073606580495834,
0.0012588913086801767,
-0.013841094449162483,
-0.021526167169213295,
-0.007956595160067081,
0.01159107405692339,
0.005181857384741306,
-0.0060120197013020515,
-0.005237169098109007,
-0.038931749761104584,
-0.021929621696472168,
0.019072365015745163,
0.03940986841917038,
-0.008483067154884338,
-0.00036029229522682726,
0.006492807995527983,
0.006550827994942665,
-0.007246603257954121,
0.016801543533802032,
0.0014495124341920018,
0.012565110810101032,
-0.0035461089573800564,
0.006303434260189533,
-0.017224721610546112,
-0.014775583520531654,
0.0003903261385858059,
-0.0017129245679825544,
-0.030197568237781525,
0.01721540465950966,
-0.015798337757587433,
0.005297507159411907,
0.009153098799288273,
0.012697978876531124,
0.016896866261959076,
0.005536322481930256,
0.017863193526864052,
-0.0016161182429641485,
0.0023185762111097574,
0.018838241696357727,
0.008554326370358467,
0.004261568654328585,
0.0016843680059537292,
-0.026051683351397514,
0.013980915769934654,
-0.00136615801602602,
-0.018541166558861732,
-0.02588464692234993,
0.0011937430826947093,
-0.01181963924318552,
0.018331024795770645,
-0.021598070859909058,
0.0007608442101627588,
-0.019021298736333847,
0.017297621816396713,
-0.00425992626696825,
0.027389779686927795,
-0.001118960091844201,
-0.013833697885274887,
0.007336829788982868,
-0.011232390999794006,
-0.006850956939160824,
0.019185561686754227,
-0.02216041460633278,
-0.0026043120305985212,
-0.003484589047729969,
0.012435647659003735,
-0.021472446620464325,
0.006016185507178307,
-0.010973136872053146,
-0.010308770462870598,
0.00453866645693779,
-0.007455425336956978,
0.007590609602630138,
-0.010533814318478107,
-0.015099010430276394,
-0.007146202027797699,
0.0036210096441209316,
-0.00046721717808395624,
-0.016783026978373528,
-0.012034572660923004,
-0.022493813186883926,
-0.011361605487763882,
-0.005087055265903473,
0.01267283782362938,
-0.008225927129387856,
-0.011326044797897339,
-0.002861425746232271,
0.011067562736570835,
-0.011565531603991985,
0.003136222017928958
] | [
0.5979065299034119,
0.2538641691207886,
-0.19344691932201385,
-0.25363317131996155,
-0.1592220813035965,
-0.08996447920799255,
0.14970576763153076,
-0.2367897629737854,
0.0016720059793442488,
-0.3023328185081482,
0.34689775109291077,
0.5450272560119629,
-0.33234652876853943,
0.08755433559417725,
0.05051730200648308,
0.6765457987785339,
0.4977162182331085,
-0.057024892419576645,
0.07106250524520874,
-0.4795399606227875,
-0.2600840926170349,
0.19507649540901184,
0.6151733994483948,
0.081186942756176,
-0.17107735574245453,
-0.016979221254587173,
0.4047401547431946,
0.09679881483316422,
-0.08248134702444077,
-0.143591046333313,
-0.06401288509368896,
0.41597893834114075,
-0.16380593180656433,
-0.10618661344051361,
-0.19609227776527405,
0.07780219614505768,
0.16732867062091827,
0.21740710735321045,
-0.10482853651046753,
-0.34393301606178284,
-0.30879470705986023,
0.19567246735095978,
0.009021256119012833,
0.4362579882144928,
0.01729290932416916,
-0.6134334802627563,
-1.6790621280670166,
0.061218682676553726,
-0.5212429761886597,
0.42419466376304626,
0.020346451550722122,
0.18150174617767334,
0.394088476896286,
0.4834654927253723,
-0.36466455459594727,
0.36226069927215576,
-0.5174113512039185,
-0.44634389877319336,
-0.16406431794166565,
-0.22158503532409668,
0.14456579089164734,
-0.15738752484321594,
0.0020276159048080444,
0.20027022063732147,
0.27601465582847595,
0.2919038236141205,
0.15219268202781677,
-0.1331799328327179,
0.1159762442111969,
-0.09495453536510468,
-0.03382641449570656,
-0.5386580228805542,
-0.45207679271698,
-0.0781235620379448,
-0.07325173169374466,
-0.4649679362773895,
-0.04274607449769974,
-0.22954866290092468,
0.5164175629615784,
-0.049381908029317856,
0.20762011408805847,
-0.230799600481987,
-0.19880439341068268,
-0.061695847660303116,
0.6715372800827026,
0.5145124197006226,
-0.4916423559188843,
0.6804706454277039,
-0.5014744400978088,
0.27561792731285095,
-0.06568484753370285,
-0.5605623126029968,
0.34798547625541687,
0.33303332328796387,
0.5562139749526978,
0.3874353766441345,
0.2198248952627182,
-0.217631995677948,
-0.4046163260936737,
0.1423826515674591,
0.11038131266832352,
-0.12728053331375122,
0.20577678084373474,
-0.5676847100257874,
-0.3782215118408203,
-0.47749099135398865,
-0.2920106053352356,
-0.5762558579444885,
0.26759007573127747,
0.14403460919857025,
-0.48048415780067444,
0.757399320602417,
-0.11106501519680023,
0.05792296305298805,
-0.13116206228733063,
0.6709837913513184,
0.2672981023788452,
-0.5900270938873291,
0.088028684258461,
0.572532594203949,
-0.4206536114215851,
0.9032173156738281,
0.1977793276309967,
0.05152209475636482,
-0.2307259440422058,
0.10657156258821487,
0.5173940658569336,
0.5647545456886292,
-0.34710821509361267,
0.5142123103141785,
0.18616503477096558,
0.7175502777099609,
-0.10391286760568619,
0.0518239364027977,
-0.002366181230172515,
0.09735953062772751,
0.3359519839286804,
0.028839485719799995,
0.1608574390411377,
0.44362717866897583,
0.015149440616369247,
-0.817171573638916,
-0.02789275534451008,
-0.12114717066287994,
-0.03367450088262558,
-0.12761522829532623,
0.14894556999206543,
-0.12982814013957977,
-0.4568213224411011,
-0.33423858880996704,
-0.023090528324246407,
0.06627164036035538,
-0.5109943747520447,
-0.037540048360824585,
0.21346552670001984,
0.7029083967208862,
-0.39694473147392273,
0.021648000925779343,
-0.21377961337566376,
0.11525554209947586,
0.1245785504579544,
-0.2699660658836365,
-0.4072571098804474,
-0.02365579828619957,
0.36098697781562805,
-0.4750441908836365,
-0.05289023369550705,
0.9144609570503235,
0.498349130153656,
-0.011838183738291264,
-0.1394367665052414,
-0.20347830653190613,
-0.13662999868392944,
-0.5152852535247803,
0.09848545491695404,
0.6359182000160217,
0.9630573987960815,
0.08881238102912903,
0.13549496233463287,
0.2673027217388153,
-0.6009100079536438,
-0.2368261218070984,
0.06621474772691727,
-0.3536407947540283,
0.6841444969177246,
-0.06704489141702652,
0.5537354946136475,
-0.15246836841106415,
-0.09051981568336487,
0.682843804359436,
-0.4163907468318939,
-0.34917449951171875,
0.6158438324928284,
-0.8025819659233093,
1.4499236345291138,
-0.30920469760894775,
-0.1496724784374237,
1.1328046321868896,
-0.6769918203353882,
-0.10470856726169586,
-0.31278496980667114,
0.49374741315841675,
0.3267311155796051,
-0.09893690049648285,
-0.45367124676704407,
-0.1659962683916092,
-0.038973357528448105,
-0.3210422992706299,
-0.4563853442668915,
0.27912041544914246,
0.44552019238471985,
0.027122346684336662,
-0.07716095447540283,
-0.3294946849346161,
-0.3481152355670929,
0.04477725550532341,
0.069328673183918,
0.3629366159439087,
-0.24865049123764038,
-0.41346579790115356,
0.8195048570632935,
-0.5280365943908691,
0.4144483804702759,
0.43855559825897217,
0.6308875679969788,
0.1800495684146881,
0.7854068875312805,
0.4014744758605957,
0.8290479779243469,
-0.4921026825904846,
0.11647164821624756,
-0.38436827063560486,
0.28144222497940063,
-0.5646125674247742,
-0.3084127604961395,
0.4454807639122009,
-0.31231561303138733,
-0.5111982226371765,
-0.3270673453807831,
0.04801059514284134,
0.36826056241989136,
0.2939205765724182,
-0.5299180150032043,
0.43893566727638245,
0.3934418261051178,
-0.31047549843788147,
0.04074222594499588,
0.5135053992271423,
-0.9494832754135132,
-0.08341546356678009,
0.02930098958313465,
0.31179213523864746,
0.37459543347358704,
-0.4178401231765747,
-0.1937340646982193,
0.017234282568097115,
-0.10095273703336716,
-0.3385109305381775,
0.4788750410079956,
-0.12145868688821793,
0.28495314717292786,
-0.1920274943113327,
0.22294914722442627,
0.07995285093784332,
0.11644229292869568,
-0.2906270921230316,
-0.7342527508735657,
-0.4687986671924591,
0.48517993092536926,
0.11821345239877701,
0.7401527762413025,
-0.046295009553432465,
-0.17553189396858215,
0.12424952536821365,
0.08857525885105133,
-0.9157048463821411,
-0.15984651446342468,
0.7024684548377991,
-0.5221864581108093,
-0.16645179688930511,
-0.1429605633020401,
0.7421784400939941,
0.3519505560398102,
-0.011158199980854988,
-0.6202704310417175,
0.1425652652978897,
0.2290399819612503,
-0.3078479468822479,
0.08032827079296112,
-0.0535319559276104,
0.2533198595046997,
0.09013282507658005,
-0.46466439962387085,
-0.6847240924835205,
0.47327902913093567,
0.43106508255004883,
-0.16512660682201385,
0.22434957325458527,
0.16397669911384583,
0.0810689851641655,
-0.2691064476966858,
0.4219481945037842,
0.3458884656429291,
-0.25040948390960693,
0.11384158581495285,
0.05977914109826088,
-0.4506860673427582,
0.07691309601068497,
-5.9133687019348145,
-0.3305721580982208,
-0.4104824364185333,
-0.24358344078063965,
-0.40718555450439453,
0.282140851020813,
0.84719318151474,
-0.3436407744884491,
-0.05769927427172661,
0.059893082827329636,
-0.10164998471736908,
0.10622675716876984,
0.20365887880325317,
0.9409253001213074,
0.3985708951950073,
0.2903396785259247,
0.05491035059094429,
0.051561132073402405,
-0.04038757085800171,
0.40969550609588623,
0.15928952395915985,
-0.761847734451294,
0.023012768477201462,
0.440310001373291,
0.4806833267211914,
-0.03696030378341675,
-0.8719559907913208,
0.45945775508880615,
0.21051765978336334,
-0.001079375622794032,
0.17831487953662872,
-0.387123167514801,
-0.1752830296754837,
-0.8108420968055725,
0.0870293378829956,
0.4312593638896942,
-0.25836366415023804,
0.11267580837011337,
0.2114093154668808,
-0.02364429458975792,
0.3920987546443939,
0.414826899766922,
-0.12546516954898834,
-0.7396602034568787,
-0.1777639538049698,
-0.13283877074718475,
0.1263926774263382,
0.3891026973724365,
-0.32329675555229187,
0.7024407982826233,
0.08291639387607574,
-0.1351960152387619,
0.5050199031829834,
-0.13960522413253784,
-0.37319156527519226,
-0.6166694164276123,
0.2704070508480072,
0.14697639644145966,
-0.024574410170316696,
-0.02756579779088497,
-0.04544565826654434,
-0.5568335652351379,
-0.02089223638176918,
-0.8428381085395813,
0.11800035834312439,
0.37290602922439575,
-0.5461291074752808,
-0.40196752548217773,
-0.08734768629074097,
0.10777290165424347,
-0.4563385248184204,
0.3943798542022705,
-0.017301447689533234,
-0.8005186915397644,
0.06301280111074448,
-0.45525312423706055,
0.1804666966199875,
0.06413406133651733,
-0.21221739053726196,
-0.12208977341651917,
-0.0698971375823021,
-0.5102670788764954,
-0.22431211173534393,
0.03631108999252319,
0.2431313544511795,
-0.4333248436450958,
-0.11644383519887924,
-0.09695291519165039,
-0.8518961668014526,
0.18348361551761627,
0.38801974058151245,
-0.47153568267822266,
0.21610338985919952,
0.6114750504493713,
0.3534487187862396,
0.4834536612033844,
0.03054419532418251,
0.01695527881383896,
0.11334922164678574,
-0.4428970515727997,
0.2908339202404022,
0.23628821969032288,
-0.016604341566562653,
-0.4951355755329132,
-0.06670983135700226,
-0.00009296559437643737,
-0.6233788132667542,
-0.1413276344537735,
0.40056824684143066,
-0.31817081570625305,
-0.3442867398262024,
-0.026588350534439087,
-0.044326070696115494,
-0.4989965558052063,
0.12391801923513412,
0.09938102215528488,
0.17189912497997284,
-0.6801207065582275,
0.38147956132888794,
-0.3341035842895508,
0.32073527574539185,
0.08356527984142303,
-0.0343642383813858,
0.534458339214325,
0.19795295596122742,
0.051147282123565674,
0.39325150847435,
0.8502057194709778,
-0.486185222864151,
-0.2702762186527252,
0.5635188221931458,
0.6482264399528503,
-0.23445545136928558,
0.21237559616565704,
0.5990444421768188,
0.06266049295663834,
-0.4941733479499817,
0.08895996958017349,
0.10216289013624191,
-0.18781043589115143,
0.37338951230049133,
-0.18400707840919495,
-0.035524990409612656,
-0.03992938622832298,
0.0012508862419053912,
0.3657405376434326,
0.4627126455307007,
-0.011915561743080616,
-0.2796315550804138,
0.28250056505203247,
0.4578110873699188,
-0.7530001401901245,
-0.31075751781463623,
-0.0933452919125557,
-0.34647080302238464,
-0.09645959734916687,
0.7101632952690125,
0.10121937841176987,
0.043563634157180786,
-0.9010146260261536,
0.1380062699317932,
0.20207075774669647,
-0.8272043466567993,
-0.47186920046806335,
0.17513267695903778,
0.2130214124917984,
0.15122780203819275,
-0.24359367787837982,
-0.3601304888725281,
0.2378486692905426,
-0.3090289831161499,
-0.4007991850376129,
-0.17971956729888916,
-0.2120913863182068,
-0.011143716983497143,
0.07708805799484253,
-0.02639785036444664,
0.006403181701898575,
-0.34018412232398987,
-0.011995088309049606,
0.46166113018989563,
-0.6453843712806702,
-0.04191495105624199,
0.21197828650474548,
0.5591605305671692,
-0.06693208962678909,
-0.18095916509628296,
-0.18328478932380676,
-0.38303089141845703,
-0.04977909475564957,
0.2526620328426361,
0.39830973744392395,
0.36661064624786377,
0.04777040705084801,
-0.7368650436401367,
-0.6318027973175049,
-0.3171466290950775,
-0.5516372323036194,
-0.12548096477985382,
-0.4591645300388336,
0.5878293514251709,
0.388326495885849,
0.0351557657122612,
0.29783526062965393,
0.5475673079490662,
-0.253879189491272,
-0.01581600122153759,
0.2931906580924988,
-0.16712422668933868,
0.07083173096179962,
-0.14114850759506226,
-0.4771912693977356,
0.07265058159828186,
0.5565111637115479,
-0.4069172739982605,
0.057336874306201935,
0.47568339109420776,
0.10749021917581558,
-0.7192258238792419,
0.13543368875980377,
0.12232064455747604,
-0.08730871230363846,
-0.2514438033103943,
-0.3726438581943512,
-0.6074312329292297,
-0.17320366203784943,
0.8485606908798218,
-0.2533594071865082,
-0.41533127427101135,
-0.024903371930122375,
-0.8325808048248291,
-0.08646002411842346,
0.30086642503738403,
-0.38173189759254456,
-0.4919605255126953,
-0.5084848403930664,
-0.23370681703090668,
0.053070101886987686,
-0.17636732757091522,
-0.09744294732809067,
-0.31473293900489807,
0.6974961161613464,
0.027080707252025604,
-0.06125552952289581,
-0.41112521290779114,
-0.23042315244674683,
0.08992920070886612,
-0.5557306408882141,
-0.502770721912384,
-0.32533231377601624,
-0.2613872289657593,
-0.12910299003124237,
-0.08241654187440872,
0.049110326915979385,
0.5319559574127197,
0.20836664736270905,
-0.31340327858924866,
-0.23576676845550537,
0.1581355482339859,
-0.11233779042959213,
-0.018990417942404747,
-0.2668299674987793,
-0.4498603343963623,
-0.29692205786705017,
0.4260840117931366,
0.24744963645935059,
-0.12495439499616623,
-0.6157397627830505,
0.11124961078166962,
-0.3530496060848236,
0.11435378342866898,
-0.20321692526340485,
0.12280672788619995,
0.24137882888317108,
0.6077824234962463,
-0.26337578892707825,
-0.2281559407711029,
-0.43767455220222473,
-0.042454417794942856,
0.4742373824119568,
-0.1681051105260849,
-0.3462304174900055,
0.49621644616127014,
-0.01679287850856781,
0.19575800001621246,
-0.5305303931236267,
0.2593851387500763,
-0.22388078272342682,
0.36037877202033997,
-0.40324893593788147,
-0.2642509341239929,
0.0010352067183703184,
-0.6108292937278748,
-0.18140099942684174,
-0.08461933583021164,
0.372830867767334,
0.558449923992157,
0.43061500787734985,
-0.38909611105918884,
-0.3003619611263275,
-0.3120187520980835,
0.504839301109314,
1.0832219123840332,
-0.3769195079803467,
0.0007031579734757543,
0.22382794320583344,
0.5344458818435669,
0.5306867957115173,
-0.2081427276134491,
0.8913581967353821,
0.4339718520641327,
0.1154070496559143,
0.17215220630168915,
1.01688551902771,
-0.8663341403007507,
-0.08493047207593918,
-0.31184855103492737,
-0.3683265149593353,
0.3854682743549347,
0.07813072949647903,
0.39793670177459717,
0.40505456924438477,
0.09625592827796936,
-0.3152274787425995,
-0.8518932461738586,
0.21256081759929657,
0.03571119159460068,
0.765950083732605,
-0.40221714973449707,
0.4160556197166443,
0.7666771411895752,
1.0345150232315063,
-0.18466177582740784,
0.07033432275056839,
0.0421118400990963,
0.34373733401298523,
0.11831854283809662,
-0.2693418562412262,
-0.3924109637737274,
0.49311381578445435,
0.429242879152298,
0.2119244933128357,
-0.04706167057156563,
-0.016105670481920242,
0.06989212334156036,
0.4220126271247864,
-0.40529951453208923,
-0.11258230358362198,
0.1442527174949646,
0.15842501819133759,
0.4575444161891937,
0.2379629909992218,
0.13793732225894928,
0.2763645350933075,
-0.5189794898033142,
-0.24403783679008484,
0.7744982838630676,
-0.6004847884178162,
-0.17340518534183502,
0.3231573700904846,
0.045594118535518646,
0.7658613920211792,
-0.0830061137676239,
0.2912243604660034,
-0.25323593616485596,
0.41402468085289,
0.8770185708999634,
-0.33889520168304443,
0.308344304561615,
0.1640835404396057,
-0.1280677318572998,
-0.07311705499887466,
-0.6133051514625549,
0.08078872412443161,
-0.03237657621502876,
-0.536963701248169,
0.07621011137962341,
-0.09176524728536606,
-0.12462177872657776,
0.4386070966720581,
-0.03601760044693947,
0.06301886588335037,
-0.2732866704463959,
-0.9565978646278381,
0.05551306903362274,
0.050213199108839035,
-0.15861688554286957,
0.22267045080661774,
0.37477561831474304,
-0.046478208154439926,
-0.1178126335144043,
-0.8730175495147705,
0.07416791468858719,
0.0870761051774025,
-0.5438891053199768,
-0.17310617864131927,
-0.0198717899620533,
0.6137036085128784,
0.27941974997520447,
-0.1966000348329544,
0.013635043054819107,
0.009672311134636402,
-0.35609865188598633,
0.4504294693470001,
-0.5233331322669983,
0.5622217059135437,
-0.5068267583847046,
-0.18990476429462433,
0.07429797947406769,
0.12424107640981674,
0.8236339688301086,
0.126752570271492,
-0.3330516815185547,
-0.08729462325572968,
-0.0017744989600032568,
0.3965514302253723,
0.37302786111831665,
-0.6164970397949219,
-0.20249693095684052,
0.028143305331468582,
-0.12093668431043625,
-0.5777073502540588,
0.49066296219825745,
-0.2664079964160919,
0.030870987102389336,
-0.18004006147384644,
0.20423240959644318,
0.1912546008825302,
-0.34760379791259766,
0.39400714635849,
0.11164172738790512,
0.0760565772652626,
-0.761500895023346,
0.28312695026397705,
-0.5683392882347107,
-0.11775539070367813,
0.32199254631996155,
-0.08137514442205429,
0.21592575311660767,
-0.3683740794658661,
-0.1298862248659134,
0.33435946702957153,
0.07362914830446243,
0.2198408544063568,
0.2766011357307434,
0.08429233729839325,
0.18571627140045166,
-0.3510947823524475,
-0.7176374793052673,
0.3950273394584656,
-0.17253658175468445,
0.2985701560974121,
-0.5677499771118164,
-0.48177242279052734,
-0.11150562018156052,
-0.324093759059906,
0.11317598074674606,
-0.5316853523254395,
0.4651046395301819,
-0.33529478311538696
] |
From an organismal perspective, cancer cell populations can be considered analogous to parasites that compete with the host for essential systemic resources such as glucose. Here, we employed leukemia models and human leukemia samples to document a form of adaptive homeostasis, where malignant cells alter systemic physiology through impairment of both host insulin sensitivity and insulin secretion to provide tumors with increased glucose. Mechanistically, tumor cells induce high-level production of IGFBP1 from adipose tissue to mediate insulin sensitivity. Further, leukemia-induced gut dysbiosis, serotonin loss, and incretin inactivation combine to suppress insulin secretion. Importantly, attenuated disease progression and prolonged survival are achieved through disruption of the leukemia-induced adaptive homeostasis. Our studies provide a paradigm for systemic management of leukemic disease. | [
-0.020293373614549637,
0.018817920237779617,
-0.0013786919880658388,
0.010658154264092445,
0.02821395918726921,
0.0024701105430722237,
0.012200654484331608,
-0.01684589684009552,
-0.012731974944472313,
-0.015959929674863815,
-0.008809920400381088,
0.005487604066729546,
-0.006271217949688435,
0.03191423788666725,
0.0009056772105395794,
0.004197814501821995,
-0.015337073244154453,
-0.03782232850790024,
0.00882025621831417,
0.0030201212503015995,
0.022550012916326523,
-0.03716503083705902,
0.01142396405339241,
0.015646247193217278,
0.023248523473739624,
0.014013774693012238,
-0.02979346737265587,
-0.01709212362766266,
-0.03570761904120445,
-0.014740264043211937,
-0.001991808880120516,
0.012754366733133793,
0.030437521636486053,
-0.016821304336190224,
0.0026374273002147675,
-0.0069433292374014854,
0.005031038075685501,
0.03252888843417168,
0.0028447350487113,
-0.00425236951559782,
0.014043423347175121,
-0.0028141795191913843,
-0.005535708274692297,
0.004246620461344719,
-0.008089523762464523,
0.011600393801927567,
0.0004206517478451133,
0.013658026233315468,
0.007638216484338045,
0.008883306756615639,
-0.001615148619748652,
-0.019683877006173134,
-0.005784382112324238,
-0.016040904447436333,
-0.007672992534935474,
0.04165607690811157,
0.022679708898067474,
0.007361223921179771,
-0.0031918128952383995,
0.014812287874519825,
-0.006200110539793968,
-0.018770892173051834,
0.027940325438976288,
-0.01935892552137375,
0.028381001204252243,
-0.06694070994853973,
0.023976275697350502,
-0.025976698845624924,
-0.023572249338030815,
-0.003872150555253029,
-0.00025267875753343105,
0.004099524579942226,
0.014330364763736725,
-0.009380752220749855,
-0.026977185159921646,
0.001286006299778819,
-0.006591157056391239,
-0.011003520339727402,
-0.006931203883141279,
0.030157238245010376,
0.011434091255068779,
-0.003970482852309942,
-0.002263816772028804,
0.024388421326875687,
0.005824362859129906,
-0.002888512797653675,
-0.019659539684653282,
-0.01520034484565258,
-0.006183566991239786,
-0.000049931928515434265,
0.013761637732386589,
-0.003307437989860773,
-0.03190241754055023,
-0.010215158574283123,
-0.020635787397623062,
0.006159333977848291,
-0.020764533430337906,
0.0007696507964283228,
0.014899748377501965,
-0.02820425108075142,
0.01208249107003212,
-0.000680432771332562,
0.022502455860376358,
0.017455535009503365,
0.006796289701014757,
0.008984029293060303,
0.009275050833821297,
-0.008818227797746658,
-0.008985576219856739,
0.014725567772984505,
-0.0025551056023687124,
0.005639779847115278,
0.000350461108610034,
0.01983228698372841,
0.04699031263589859,
-0.0033870218321681023,
-0.012216098606586456,
-0.01796543225646019,
0.014248673804104328,
-0.014909619465470314,
-0.009764470160007477,
0.008609337732195854,
-0.010144548490643501,
0.0066376179456710815,
0.0068324264138937,
-0.0007135150954127312,
0.005639250855892897,
0.009693512693047523,
0.021248940378427505,
-0.005163636524230242,
-0.007998419925570488,
-0.0036426011938601732,
0.03565702587366104,
-0.012923343107104301,
-0.0019788274075835943,
-0.001408987445756793,
-0.018630413338541985,
0.02337537705898285,
0.01284160278737545,
-0.03054288774728775,
0.015649618580937386,
0.007098031230270863,
0.0001838795724324882,
0.005807314999401569,
0.002789504826068878,
0.011978228576481342,
-0.016821786761283875,
0.007239494472742081,
0.01593831367790699,
-0.010412514209747314,
0.014444205909967422,
0.005637915339320898,
0.002890709089115262,
-0.016152016818523407,
0.03957571089267731,
0.022645525634288788,
-0.013759974390268326,
-0.0035320566967129707,
-0.010125204920768738,
-0.009868835099041462,
-0.031084485352039337,
-0.022428162395954132,
0.03407415375113487,
0.010162534192204475,
0.020110568031668663,
0.009568058885633945,
0.012698056176304817,
-0.012861724942922592,
0.002813053783029318,
0.009931737557053566,
-0.011959308758378029,
-0.01697756163775921,
-0.0009755589999258518,
0.011954233050346375,
-0.009839139878749847,
0.010114489123225212,
0.0192232858389616,
0.010087596252560616,
0.0029808806721121073,
0.06648705899715424,
-0.017148952931165695,
0.03562260419130325,
-0.005212215706706047,
-0.04501945525407791,
0.02157985419034958,
-0.0020407577976584435,
0.0030579951126128435,
-0.010527310892939568,
-0.010627690702676773,
0.02045733481645584,
-0.008805686607956886,
-0.009293986484408379,
-0.035140953958034515,
-0.0051371511071920395,
-0.025447338819503784,
0.004206830635666847,
-0.003556676674634218,
0.0006819124100729823,
0.0007254693191498518,
0.017535390332341194,
-0.026204179972410202,
0.0007313587702810764,
0.032671719789505005,
-0.016062462702393532,
0.0032536813523620367,
0.01883520372211933,
-0.01206353772431612,
-0.0034385391045361757,
0.008156279101967812,
-0.021502843126654625,
0.03131113201379776,
-0.030301257967948914,
-0.004002171568572521,
-0.004615862853825092,
0.0065546706318855286,
0.008660910651087761,
-0.006945560686290264,
-0.005068011581897736,
-0.016048774123191833,
-0.011806827038526535,
-0.002443070523440838,
0.016361642628908157,
0.011037678457796574,
0.014227127656340599,
0.01692693680524826,
-0.006604705937206745,
0.0019167414866387844,
0.01186523586511612,
-0.013080989941954613,
0.0018558725714683533,
-0.023344509303569794,
-0.03366204351186752,
-0.010283930227160454,
-0.004927994683384895,
0.0101962024345994,
0.025574717670679092,
0.016024336218833923,
-0.029131613671779633,
0.010658667422831059,
-0.020232534036040306,
0.009775999002158642,
0.00809374637901783,
0.05072504281997681,
-0.00643784087151289,
-0.012995883822441101,
0.008366825059056282,
0.02936805598437786,
0.017284225672483444,
0.016299691051244736,
-0.016543984413146973,
0.006884059403091669,
0.002558120060712099,
0.0054800258949398994,
-0.011459942907094955,
-0.008487808518111706,
-0.010028239339590073,
0.0028773732483386993,
-0.013285785913467407,
0.02741585671901703,
-0.0014496395597234368,
-0.007841994985938072,
0.005988934077322483,
-0.0057385629042983055,
0.0025855815038084984,
0.009249944239854813,
-0.002061303239315748,
-0.028602056205272675,
0.01123012974858284,
0.01031494140625,
0.005839336663484573,
0.0060370503924787045,
0.0004871753044426441,
0.0076241446658968925,
-0.08171457052230835,
-0.019502831622958183,
0.008388850837945938,
0.023957673460245132,
0.009133690968155861,
-0.0230502188205719,
0.01990823820233345,
0.019174303859472275,
-0.0008084859582595527,
-0.007340186275541782,
0.003812232054769993,
0.01745610311627388,
-0.00883518811315298,
0.00023553497157990932,
-0.008708901703357697,
-0.007188970223069191,
0.005513014271855354,
-0.015687745064496994,
0.003568171989172697,
-0.01391393132507801,
0.029609687626361847,
-0.0025655776262283325,
-0.002229150850325823,
-0.016092870384454727,
-0.006283562630414963,
0.004213056992739439,
0.01352678518742323,
-0.0014919613022357225,
0.007698352914303541,
0.011286726221442223,
0.0033058542758226395,
-0.004818325862288475,
0.013472463935613632,
0.004348339047282934,
0.024458210915327072,
-0.009399132803082466,
0.014455357566475868,
0.011573513969779015,
-0.011997947469353676,
0.021453510969877243,
-0.0031682560220360756,
0.0063636405393481255,
0.02934115380048752,
-0.00018262770026922226,
0.03556375950574875,
0.01264137588441372,
0.011230727657675743,
0.04845288395881653,
0.009594844654202461,
0.0018358705565333366,
0.02639327198266983,
0.008649596944451332,
0.006257501430809498,
0.01291557215154171,
-0.011820324696600437,
-0.01453174464404583,
-0.03396414965391159,
-0.002514648251235485,
-0.015668073669075966,
-0.012104015797376633,
0.021619731560349464,
0.0016983821988105774,
0.0059495908208191395,
0.025138285011053085,
-0.007630237843841314,
0.013613007962703705,
0.02093866467475891,
-0.008514036424458027,
-0.008983243256807327,
0.011616501957178116,
-0.021699996665120125,
-0.01619836874306202,
-0.010997331701219082,
-0.006456693634390831,
0.013391440734267235,
-0.00033768429420888424,
-0.015234176069498062,
-0.021804863587021828,
0.0054276785813272,
-0.001252210233360529,
-0.033560946583747864,
-6.58910721540451e-7,
-0.024164622649550438,
0.006196959875524044,
-0.013356545008718967,
-0.018404439091682434,
0.0030843515414744616,
0.023389767855405807,
0.00641047116369009,
-0.016213934868574142,
0.04722828418016434,
0.013893986120820045,
-0.025320840999484062,
0.011554169468581676,
0.020164363086223602,
0.0059197330847382545,
0.011768879368901253,
-0.0026285345666110516,
0.02387874200940132,
0.011037440970540047,
-0.04017053544521332,
0.006871405057609081,
-0.007156975567340851,
-0.011294754222035408,
-0.008975544944405556,
0.014741013757884502,
0.016392964869737625,
0.008828801102936268,
-0.019062329083681107,
-0.002753947861492634,
-0.008049437776207924,
0.02222936600446701,
-0.009912801906466484,
0.024589359760284424,
0.010674472898244858,
0.016951758414506912,
0.000049570342525839806,
-0.021704837679862976,
0.07128842175006866,
0.009698743000626564,
0.002723424695432186,
-0.02121986821293831,
0.03675748407840729,
-0.02686496451497078,
0.012608220800757408,
0.01694438047707081,
-0.03947305679321289,
0.011627297848463058,
0.01490027830004692,
-0.019420575350522995,
-0.006746547296643257,
-0.008456944487988949,
-0.025153139606118202,
0.01429709605872631,
-0.0033177214208990335,
-0.02108027972280979,
0.004112699534744024,
-0.02191651612520218,
-0.025070426985621452,
0.02631392702460289,
-0.020884787663817406,
0.02328803390264511,
-0.00227799778804183,
-0.02572895959019661,
-0.000026063993573188782,
-0.01328323595225811,
-0.014843548648059368,
0.007916780188679695,
-0.01024529617279768,
0.004685789346694946,
-0.0026873964816331863,
0.005835725925862789,
0.030256183817982674,
0.005243984051048756,
0.01388248149305582,
-0.006143094506114721,
-0.0030300964135676622,
-0.004013208206743002,
-0.034463152289390564,
-0.014105197042226791,
0.010636277496814728,
0.023964809253811836,
-0.004006828647106886,
-0.0025047273375093937,
0.014059778302907944,
-0.00725867785513401,
-0.010264290496706963,
-0.00021629268303513527,
-0.021391477435827255,
-0.00374571792781353,
0.0112946517765522,
0.010731974616646767,
-0.020571928471326828,
-0.0063040368258953094,
0.009362119249999523,
-0.005747320130467415,
-0.00022191647440195084,
-0.021336950361728668,
-0.0072372062131762505,
0.029898017644882202,
0.041737280786037445,
-0.015954243019223213,
0.02071608416736126,
-0.004348414950072765,
-0.02508419379591942,
0.007004800718277693,
0.041758932173252106,
-0.03121907263994217,
0.011849877424538136,
-0.011184155009686947,
-0.013721679337322712,
0.005135352723300457,
-0.007044646888971329,
0.0437796376645565,
-0.025079715996980667,
0.013489318080246449,
0.00873772706836462,
0.009962597861886024,
0.002106550382450223,
-0.02326323464512825,
0.025093141943216324,
-0.02608473040163517,
-0.006388880778104067,
0.016836073249578476,
0.01419930998235941,
-0.07431928813457489,
0.01284730900079012,
0.007113953586667776,
-0.007216988131403923,
-0.0015608773101121187,
-0.021022364497184753,
-0.0067408159375190735,
0.0036124419420957565,
-0.005225528031587601,
-0.007689668796956539,
-0.007665514480322599,
-0.007979806512594223,
0.03759671375155449,
0.01355644129216671,
0.014432914555072784,
0.013399328105151653,
-0.012324613519012928,
-0.021476350724697113,
-0.031057827174663544,
0.007994408719241619,
0.02600661851465702,
-0.020312335342168808,
-0.008406559005379677,
0.025264661759138107,
0.001232062466442585,
-0.08005809038877487,
0.013635436072945595,
-0.012788917869329453,
-0.02675340510904789,
0.0053707570768892765,
-0.02271246537566185,
-0.0097111277282238,
0.0024606159422546625,
-0.02501566708087921,
-0.01969492994248867,
-0.015631118789315224,
-0.011570925824344158,
0.022921279072761536,
-0.010918265208601952,
-0.0003943487536162138,
-0.007615385577082634,
0.0111125148832798,
-0.002893242985010147,
-0.003255481831729412,
0.016670072451233864,
0.007292186841368675,
0.029789142310619354,
-0.011665569618344307,
-0.005806867964565754,
-0.00953320786356926,
0.021105991676449776,
-0.0034873944241553545,
0.008589494042098522,
-0.016455888748168945,
0.02016383223235607,
0.0063519710674881935,
-0.015640180557966232,
-0.023648560047149658,
-0.03710095211863518,
-0.040416281670331955,
-0.01678922399878502,
0.034860722720623016,
0.004406114108860493,
0.01011623628437519,
0.0011409251019358635,
-0.0066560604609549046,
0.008400505408644676,
-0.012136520817875862,
0.04001288861036301,
0.01910243183374405,
0.019071979448199272,
0.007475886959582567,
-0.0029897401109337807,
0.01241744589060545,
0.017291659489274025,
0.008496010676026344,
0.010556438006460667,
0.004410240799188614,
0.002653535921126604,
-0.01846679113805294,
0.012503419071435928,
-0.0013146020937711,
0.0029962407425045967,
-0.0021273386664688587,
0.02489597536623478,
-0.007234557066112757,
-0.019887380301952362,
0.0008758050389587879,
0.07160195708274841,
-0.02684812992811203,
0.02150382287800312,
0.0033808541484177113,
-0.010711942799389362,
0.0002014392230194062,
-0.029104938730597496,
0.022569801658391953,
-0.014204736799001694,
-0.001827526604756713,
0.004138401709496975,
-0.012813284061849117,
0.00239386223256588,
0.015502216294407845,
-0.016636136919260025,
-0.02549890987575054,
0.012539172545075417,
0.0013197949156165123,
0.02122323587536812,
0.006358920596539974,
0.006191428750753403,
-0.009470123797655106,
-0.027928676456212997,
0.011442936956882477,
0.029661083593964577,
-0.01255607046186924,
-0.01871204935014248,
-0.01329631358385086,
-0.013206418603658676,
-0.0039037950336933136,
-0.0006460465956479311,
0.03267315775156021,
-0.0006479937583208084,
-0.023032421246170998,
0.028849229216575623,
0.025529589504003525,
-0.01923144981265068,
-0.004214301705360413,
-0.024215945973992348,
0.0017160808201879263,
0.013202672824263573,
0.006712222006171942,
-0.002955799922347069,
-0.017158307135105133,
0.014091962948441505,
-0.018316850066184998,
0.009053000248968601,
-0.045596495270729065,
-0.013547040522098541,
0.013246203772723675,
-0.0009272173047065735,
0.0054907603189349174,
-0.028745492920279503,
-0.010952075943350792,
0.013107567094266415,
-0.004137851297855377,
0.00635221041738987,
0.013363709673285484,
-0.018632125109434128,
-0.009140840731561184,
-0.0030690007843077183,
-0.014264622703194618,
0.003623830620199442,
-0.019079342484474182,
0.01246336568146944,
0.00479379016906023,
0.012334824539721012,
-0.017345160245895386,
0.009297753684222698,
0.017879851162433624,
0.004120240919291973,
0.016034182161092758,
0.010561272501945496,
-0.007770680822432041,
0.026643723249435425,
0.0017668413929641247,
0.017062662169337273,
0.007859008386731148,
-0.007258350029587746,
0.024681147187948227,
0.002606799826025963,
0.0069055696949362755,
0.01570700854063034,
-0.00008866714779287577,
-0.034557923674583435,
0.006210250314325094,
0.014913972467184067,
-0.004116388037800789,
-0.007305937819182873,
0.008620073087513447,
0.006895362865179777,
-0.0008892959449440241,
-0.0015479042194783688,
0.016544291749596596,
0.005474915727972984,
0.03553937375545502,
0.008067402988672256,
0.0015251168515533209,
0.01635831966996193,
0.019797001034021378,
-0.019691428169608116,
-0.024738537147641182,
-0.001131158322095871,
-0.010769232176244259,
-0.03361694514751434,
-0.006348712369799614,
0.015367458574473858,
0.0015305988490581512,
0.019500870257616043,
0.0020403615199029446,
0.0154119823127985,
-0.02134314551949501,
0.03164781630039215,
0.03014758601784706,
0.008329588919878006,
0.022042464464902878,
-0.011161928996443748,
0.02685549668967724,
-0.02916610799729824,
-0.010880952700972557,
0.0024075645487755537,
0.006850471254438162,
-0.008310414850711823,
0.011024780571460724,
-0.003481269581243396,
-0.003987090662121773,
-0.019104866310954094,
-0.0038640093989670277,
-0.016077224165201187,
0.018411127850413322,
0.010506602004170418,
-0.03231694549322128,
0.0057724593207240105,
0.027038805186748505,
0.0046956464648246765,
0.026546798646450043,
0.01302050705999136,
0.026666732504963875,
-0.016034765169024467,
0.016369739547371864,
-0.0198199599981308,
0.00039687962271273136,
-0.0026100734248757362,
-0.0015858615515753627,
0.007913362234830856,
-0.004749867133796215,
0.01377415657043457,
-0.01648804172873497,
0.021188095211982727,
0.010507307946681976,
-0.0062675392255187035,
0.0219213105738163,
-0.0008910904871299863,
-0.008236379362642765,
-0.025974091142416,
0.018304452300071716,
0.009214270859956741,
0.012815047986805439,
-0.0026604714803397655,
0.016144396737217903,
0.0095407385379076,
-0.030362943187355995,
-0.014859436079859734,
-0.006641661282628775,
0.01023934967815876,
0.027928361669182777,
-0.02097456529736519,
-0.027852503582835197,
-0.0047785136848688126,
-0.00585304806008935,
0.012373500503599644,
-0.004135442897677422,
-0.017286822199821472,
0.030400818213820457,
-0.03033159300684929,
-0.01105529349297285,
-0.02938251383602619,
-0.0008344424422830343,
0.009909084066748619,
0.0012690507574006915,
-0.011452509090304375,
-0.0002162849996238947,
0.0044736964628100395,
-0.004797386471182108,
-0.02381110191345215,
0.01372756902128458,
0.0018064317991957068,
-0.0018557781586423516,
0.012650161981582642,
-0.03673278167843819,
-0.013971352018415928,
-0.008181331679224968,
0.0020536312367767096,
0.010186180472373962,
-0.01055498979985714,
-0.006892392411828041,
-0.029659917578101158,
-0.01907278224825859,
-0.007300162222236395,
0.009969674050807953,
0.029320400208234787,
-0.011768310330808163
] | [
0.20725475251674652,
0.047353990375995636,
-0.03775651380419731,
0.15571889281272888,
0.3021996319293976,
0.17626124620437622,
0.4271835684776306,
-0.10238130390644073,
-0.03332751616835594,
-0.6841490268707275,
0.8394877314567566,
0.06053915619850159,
-0.6741384863853455,
0.4075016379356384,
-0.21732209622859955,
0.21201671659946442,
0.47933125495910645,
0.6335292458534241,
-0.02258402854204178,
0.009553798474371433,
-0.4185432493686676,
0.1793697476387024,
0.6188530325889587,
0.18036366999149323,
0.001982878427952528,
-0.3925715982913971,
0.47806692123413086,
0.14382211863994598,
0.31069856882095337,
0.014530099928379059,
-0.30286651849746704,
0.5639951825141907,
0.3037644922733307,
-0.14505934715270996,
-0.4677799940109253,
-0.1549185812473297,
-0.2873263657093048,
0.14175650477409363,
0.06061899662017822,
-0.18900810182094574,
-0.5462722182273865,
0.03139704465866089,
-0.22006650269031525,
0.44654667377471924,
-0.14215843379497528,
-0.30913394689559937,
-1.546197533607483,
0.7919904589653015,
-0.1687227040529251,
0.2153124064207077,
-0.1005076989531517,
-0.010843655094504356,
0.2840738594532013,
0.22346490621566772,
0.152143195271492,
0.2658627927303314,
-0.2870623767375946,
0.11662507057189941,
0.5228248834609985,
-0.7143797278404236,
0.1298021823167801,
-0.1871350258588791,
-0.23702913522720337,
0.045815590769052505,
-0.1737583726644516,
0.8161312341690063,
0.3625986874103546,
-0.44032788276672363,
-0.6012627482414246,
-0.43946874141693115,
-0.16685722768306732,
-0.5756694674491882,
0.037772126495838165,
0.7684648633003235,
-0.28635188937187195,
-0.35440197587013245,
-0.36344730854034424,
-0.22631026804447174,
0.13712678849697113,
-0.10719829797744751,
0.015192708931863308,
0.14044827222824097,
0.2083738148212433,
0.23060667514801025,
0.27660712599754333,
0.20656049251556396,
0.13680559396743774,
0.7517659664154053,
-0.582280695438385,
-0.3219909071922302,
-0.005098147317767143,
0.07617810368537903,
0.5430979132652283,
0.3299204409122467,
0.48120781779289246,
0.286312460899353,
0.24285753071308136,
-0.18400630354881287,
0.2098633199930191,
0.35670217871665955,
-0.2129078209400177,
-0.6007610559463501,
-0.1759042590856552,
-0.3669663071632385,
-0.42847388982772827,
-0.3832143247127533,
-0.12625034153461456,
-0.32592111825942993,
-0.32162588834762573,
0.2036290019750595,
-0.6736239194869995,
0.4372308850288391,
-0.4642605185508728,
0.008315003477036953,
-0.1886085718870163,
0.027360647916793823,
-0.04471132531762123,
-0.566443681716919,
-0.14869476854801178,
-0.28955304622650146,
-0.06940732151269913,
1.3800190687179565,
-0.38380560278892517,
0.22248108685016632,
-0.15933944284915924,
-0.06049983948469162,
0.23601646721363068,
-0.26923105120658875,
0.06867168098688126,
0.5818628072738647,
0.28094103932380676,
0.7446246147155762,
-0.0893365889787674,
-0.12474887073040009,
0.32916781306266785,
-0.12207338958978653,
0.27048131823539734,
0.33352693915367126,
-0.03646586462855339,
-0.1558358371257782,
-0.3371622860431671,
-0.6512460708618164,
0.20351240038871765,
-0.04466020315885544,
0.0318826399743557,
-0.513977587223053,
-0.09156189113855362,
-0.3699937164783478,
0.12735141813755035,
-0.43821120262145996,
-0.19112975895404816,
0.10823126882314682,
-0.5706591606140137,
0.15455561876296997,
0.3092287480831146,
0.6954659819602966,
-0.06662264466285706,
-0.4368427097797394,
0.4843473732471466,
0.4091593027114868,
0.161423459649086,
-0.1727457344532013,
-0.3587038815021515,
-0.33823058009147644,
0.30338358879089355,
-0.1357288807630539,
0.4521096348762512,
0.6817557215690613,
-0.018793607130646706,
-0.15049844980239868,
-0.4449954926967621,
-0.25316596031188965,
-0.09262838959693909,
-0.2337518036365509,
0.10756481438875198,
-0.33816176652908325,
0.09645956009626389,
-0.22606445848941803,
-0.08984003961086273,
0.2546004354953766,
-0.6963354349136353,
0.12347916513681412,
-0.1837117224931717,
-0.5023531913757324,
0.2463255673646927,
-0.2833053767681122,
0.4277368187904358,
0.20058514177799225,
0.14879871904850006,
-0.15693990886211395,
-0.15567241609096527,
-0.15921342372894287,
0.7422112822532654,
-0.6559284329414368,
1.3577356338500977,
-0.3940022885799408,
-0.1675804704427719,
0.9967390298843384,
0.1845180094242096,
-0.4177417755126953,
0.07066676020622253,
-0.2886301577091217,
0.194795161485672,
-0.5195048451423645,
-0.4027921259403229,
-0.18729615211486816,
-0.06673233211040497,
-0.7029439806938171,
0.07071749120950699,
-0.06673675775527954,
0.5496550798416138,
-0.20105832815170288,
-0.04232839122414589,
-0.27868831157684326,
0.08998864144086838,
-0.3749788999557495,
-0.37793439626693726,
0.30674058198928833,
-0.5707509517669678,
-0.031194571405649185,
0.3356655538082123,
-0.5728703737258911,
0.5624939203262329,
0.8032586574554443,
0.38915160298347473,
0.5719167590141296,
0.7398059368133545,
0.13569582998752594,
0.7574647665023804,
-0.2998809516429901,
0.7158392071723938,
-0.3236718475818634,
0.19441090524196625,
-0.49527305364608765,
-0.13133758306503296,
0.3385256230831146,
0.15162363648414612,
0.17010915279388428,
0.024745695292949677,
-0.3654996454715729,
-0.12160680443048477,
0.46396785974502563,
-0.8561275005340576,
-0.12738634645938873,
0.07260747998952866,
-0.7584187388420105,
-0.45290273427963257,
0.19660808145999908,
-1.2707217931747437,
-0.3821865916252136,
0.02568635530769825,
0.32840290665626526,
0.4739944338798523,
-0.5302164554595947,
-0.07653245329856873,
0.0016716852551326156,
-0.08223352581262589,
-0.08488841354846954,
0.18085338175296783,
-0.43330949544906616,
-0.2215837836265564,
-0.052607521414756775,
0.17256245017051697,
0.31138288974761963,
-0.11726398766040802,
-0.30521610379219055,
-0.6836280226707458,
-0.8053238987922668,
0.6582778096199036,
0.8783183097839355,
1.1378623247146606,
-0.05322684720158577,
-0.602188766002655,
-0.14988864958286285,
0.05813424661755562,
-0.637522280216217,
0.07068800181150436,
0.5711275339126587,
-0.32015514373779297,
-0.14203204214572906,
-0.10357730090618134,
0.5536081790924072,
0.6520784497261047,
-0.3411083519458771,
-0.3406006395816803,
-0.30535557866096497,
0.037356626242399216,
-0.20388807356357574,
-0.3064400255680084,
0.2354474514722824,
-0.16312739253044128,
0.38276785612106323,
-0.6448672413825989,
-0.27052658796310425,
0.4073007106781006,
0.17838919162750244,
-0.14136070013046265,
-0.018330194056034088,
0.6597079634666443,
0.011479241773486137,
-0.2144472450017929,
-0.12678584456443787,
-0.02007756568491459,
-0.021576514467597008,
-0.28907522559165955,
-0.022060638293623924,
-0.13764367997646332,
0.3618737757205963,
-5.945814609527588,
-0.20827721059322357,
0.29506999254226685,
-0.08143376559019089,
-0.2819618880748749,
-0.2478499561548233,
0.6926167607307434,
0.34647294878959656,
0.19517025351524353,
0.32816576957702637,
0.3072015643119812,
0.2614544630050659,
-0.11640550941228867,
0.0036648765671998262,
-0.33995455503463745,
-0.20254646241664886,
0.0534854419529438,
-0.1383492797613144,
0.4724771976470947,
-0.1282850205898285,
0.11174895614385605,
-0.14412325620651245,
0.1541990339756012,
0.7622498273849487,
-0.15261363983154297,
0.009967225603759289,
-1.2104934453964233,
0.26070448756217957,
0.0841103047132492,
-0.09579680860042572,
-0.3998449742794037,
-0.5727199912071228,
0.2900960445404053,
-0.3271969258785248,
0.41900530457496643,
0.2834136188030243,
-0.4550844430923462,
0.12456943094730377,
-0.21677842736244202,
-0.508648693561554,
0.20055198669433594,
0.24225665628910065,
-0.6441697478294373,
0.019922280684113503,
0.3298053741455078,
0.21043968200683594,
-0.21246936917304993,
0.41910815238952637,
-0.5860633254051208,
0.4352213442325592,
-0.17011985182762146,
-0.10085127502679825,
0.7324936985969543,
0.43074432015419006,
0.3275425136089325,
0.10632731020450592,
-0.024328451603651047,
-0.14738523960113525,
-0.2584628462791443,
-0.17247840762138367,
-0.34902501106262207,
-0.19344888627529144,
-0.11864947527647018,
-0.07007134705781937,
0.47947078943252563,
0.19445760548114777,
-0.4164241552352905,
-0.4604140520095825,
0.4607204794883728,
-0.42797183990478516,
-0.19015997648239136,
0.12510398030281067,
0.47092410922050476,
-0.7442365288734436,
0.3143559694290161,
-0.47960686683654785,
0.003468964481726289,
0.04209498316049576,
0.13668830692768097,
-0.09588392823934555,
-0.45798489451408386,
0.044788140803575516,
-0.2778397798538208,
-0.33141177892684937,
0.5319309234619141,
-0.5916439294815063,
-0.6904256939888,
0.03096243180334568,
-0.28473711013793945,
0.8111528158187866,
0.5024895668029785,
0.0478978306055069,
0.4947560727596283,
0.7278961539268494,
0.28772181272506714,
0.4023154079914093,
0.3037261366844177,
0.24410097301006317,
0.28455036878585815,
-0.1802261471748352,
0.4741528034210205,
0.11481416970491409,
-0.5467362403869629,
-0.5189115405082703,
0.40239861607551575,
0.2932095229625702,
-0.838671863079071,
0.2832566201686859,
0.2971448004245758,
-0.7693293690681458,
-0.029230279847979546,
0.20516064763069153,
-0.18175573647022247,
-0.4573163688182831,
0.40429678559303284,
-0.26964622735977173,
-0.37418004870414734,
0.18656428158283234,
0.922705888748169,
-0.31916800141334534,
-0.0017351957503706217,
0.539381742477417,
-0.2978549897670746,
0.16973429918289185,
0.1985146403312683,
-0.11768555641174316,
0.11276274919509888,
0.6536321640014648,
-0.3098445534706116,
-0.2434816062450409,
0.6498681902885437,
0.4360928535461426,
-0.4536624550819397,
-0.08372636884450912,
0.295382559299469,
-0.30981454253196716,
-0.1569124162197113,
0.2946745455265045,
0.19077247381210327,
-0.3027362823486328,
0.3292563259601593,
-0.26501986384391785,
0.1533328890800476,
-0.28856539726257324,
0.03400920331478119,
0.1566295027732849,
0.2373579889535904,
-0.05660080537199974,
-0.12925659120082855,
-0.17525248229503632,
0.0278518907725811,
0.11480702459812164,
-0.09992306679487228,
-0.146673321723938,
-0.6028802990913391,
0.11092177033424377,
0.7451876401901245,
-0.08534437417984009,
0.06877401471138,
-0.06056110933423042,
0.13651162385940552,
0.23462547361850739,
-0.965589165687561,
0.04633379355072975,
-0.5156804323196411,
0.15884985029697418,
-0.3216715157032013,
0.012420246377587318,
0.06345029175281525,
0.10397424548864365,
-0.24733713269233704,
-0.42205849289894104,
-0.3384486436843872,
-0.05519856885075569,
0.14929300546646118,
-0.8064189553260803,
-0.04844798520207405,
0.18225130438804626,
-0.10206492990255356,
0.43734073638916016,
0.4312138855457306,
-0.7191745638847351,
-0.43274208903312683,
0.1362578421831131,
0.811102569103241,
0.17764395475387573,
0.23334535956382751,
-0.04100525751709938,
-0.41111648082733154,
-0.3936368525028229,
0.1202351525425911,
0.171086385846138,
0.5735536217689514,
-0.39565086364746094,
0.46908313035964966,
0.02351411245763302,
-0.08345819264650345,
0.19906234741210938,
0.19122694432735443,
-0.5921369194984436,
0.012240980751812458,
0.34682124853134155,
-0.5765407085418701,
0.2617315649986267,
0.3749413788318634,
0.11675120890140533,
-0.6045128107070923,
-0.14735250174999237,
0.1290634572505951,
-0.32090842723846436,
-0.5664218664169312,
-0.4183216989040375,
0.08392047137022018,
0.5307276844978333,
0.01667267270386219,
-0.09103615581989288,
0.3726683259010315,
-0.12099193781614304,
-0.2380581498146057,
0.47949105501174927,
0.6826072931289673,
-0.10276135802268982,
-0.3142351806163788,
-0.028764868155121803,
-0.3167727291584015,
0.1222095862030983,
0.28689995408058167,
-0.6230101585388184,
0.14152687788009644,
0.010064184665679932,
-0.025571178644895554,
-0.08857250213623047,
-0.13258516788482666,
-0.036996837705373764,
-0.083814337849617,
-0.3812830150127411,
0.05803024023771286,
0.3626363277435303,
-0.21287551522254944,
0.2034391313791275,
0.21550890803337097,
0.7091513872146606,
-0.3626566231250763,
-0.08513772487640381,
0.27341073751449585,
0.6598054766654968,
0.24174879491329193,
-0.5296091437339783,
-0.49918311834335327,
-0.11207796633243561,
0.20736439526081085,
-0.11879894882440567,
0.2647234797477722,
0.5646635293960571,
0.9879658818244934,
-0.1388109028339386,
-0.03109411895275116,
-0.4775005280971527,
-0.09141813963651657,
0.114879310131073,
-0.38354337215423584,
-0.2422601729631424,
-0.24452976882457733,
-0.09928078949451447,
0.2956887185573578,
0.06450667232275009,
-0.1256210207939148,
-0.2213350236415863,
0.45389825105667114,
-0.2719685435295105,
0.2698182165622711,
-0.006692735478281975,
0.1746160238981247,
0.4283539056777954,
0.056740567088127136,
0.3124401867389679,
-0.3086978495121002,
0.21301691234111786,
-0.15755392611026764,
0.08341699838638306,
-0.17321659624576569,
-0.619809627532959,
0.0010934319579973817,
-0.6080856323242188,
0.497176855802536,
-0.5608106851577759,
0.5096772313117981,
-0.7529452443122864,
0.14863161742687225,
-0.38950061798095703,
-0.3996890187263489,
-0.29166901111602783,
-0.14113710820674896,
-0.763721764087677,
0.12581168115139008,
0.4227522611618042,
0.1769980639219284,
0.1297864466905594,
-0.0544881746172905,
-0.12203104794025421,
-0.5397288799285889,
0.34708812832832336,
0.44639670848846436,
-0.2879171371459961,
0.12298239022493362,
0.19941526651382446,
0.021799342706799507,
0.0009578227181918919,
-0.681662380695343,
-0.35630476474761963,
0.13904665410518646,
-0.007060461211949587,
0.4298575818538666,
0.09395288676023483,
-0.20549190044403076,
0.3837968707084656,
-0.5312033891677856,
-0.3534319996833801,
0.25414592027664185,
0.1821071058511734,
0.16565687954425812,
0.08481045812368393,
0.21571752429008484,
-0.4428713023662567,
0.28104346990585327,
0.16264009475708008,
0.401135116815567,
-0.2569028437137604,
-0.42581841349601746,
0.8233698010444641,
0.726809024810791,
0.5446364283561707,
-0.46500924229621887,
0.29760274291038513,
0.3602662980556488,
0.30966347455978394,
0.14351673424243927,
-0.08448825031518936,
-0.4186454117298126,
0.08386195451021194,
0.8286935091018677,
0.24882301688194275,
-0.30067697167396545,
0.015353094786405563,
0.1817365139722824,
0.0683712363243103,
-0.0060876901261508465,
0.2927509844303131,
-0.22699488699436188,
0.15809085965156555,
0.1389441043138504,
-0.4426378309726715,
-0.5209065079689026,
0.4709898829460144,
-0.3524284362792969,
-0.051162879914045334,
0.5979954600334167,
-0.6992061734199524,
-0.12625640630722046,
0.06432287395000458,
-0.22940650582313538,
-0.03800692409276962,
0.08906414359807968,
0.497061163187027,
0.23381763696670532,
0.1947297602891922,
0.3864194452762604,
-0.16640906035900116,
0.4325794279575348,
-0.11997830122709274,
0.06990134716033936,
0.034050144255161285,
-0.046788349747657776,
-0.17217931151390076,
0.12092220038175583,
-0.11879193782806396,
0.20299132168293,
-0.04005550220608711,
0.2092054933309555,
0.14465083181858063,
-0.4966926872730255,
-0.008892465382814407,
-0.13162091374397278,
-0.6570740342140198,
-0.17962007224559784,
0.009195128455758095,
-0.4151610732078552,
0.1660412847995758,
0.29362255334854126,
0.4140460193157196,
0.45016515254974365,
-0.7848875522613525,
0.48188331723213196,
0.29067644476890564,
0.39241576194763184,
0.4220661222934723,
0.13634233176708221,
0.22974881529808044,
0.5106079578399658,
0.07734572142362595,
-0.08751664310693741,
0.10172870755195618,
-0.1625363528728485,
0.5899901390075684,
-0.7410346269607544,
0.6283010244369507,
-0.553285539150238,
-0.6365355849266052,
-0.3584109842777252,
-0.10595937818288803,
1.1472959518432617,
0.017343653365969658,
-0.1277070939540863,
0.22156187891960144,
0.1513681560754776,
0.5562893748283386,
0.028065338730812073,
-0.6779431700706482,
-0.4019259214401245,
-0.6135733127593994,
-0.08483442664146423,
-0.41606131196022034,
0.7550929188728333,
-0.03994312509894371,
-0.32114553451538086,
0.05579822510480881,
0.17044314742088318,
0.06760764122009277,
-0.20151302218437195,
0.399884968996048,
-0.46907472610473633,
0.6071394085884094,
-0.61460280418396,
-0.07775477319955826,
-0.4091300964355469,
0.07633161544799805,
-0.13601486384868622,
0.042390674352645874,
-0.0719846710562706,
-0.11662524938583374,
0.11980345100164413,
-0.07532218098640442,
0.5144073367118835,
0.1491859257221222,
0.34451574087142944,
0.07772114127874374,
0.07569064199924469,
-0.6165271997451782,
-0.41544803977012634,
0.061239153146743774,
0.1365993469953537,
-0.20167583227157593,
-0.33118095993995667,
0.18545864522457123,
-0.02645016647875309,
0.33468666672706604,
0.11627884954214096,
-0.41886597871780396,
-0.20256569981575012,
0.04888426512479782
] |
BACKGROUND Exosomes are extracellular vesicles that mediate cellular communication in health and diseases. Neutrophils could be polarized to a pro-tumor phenotype by tumor. The function of tumor-derived exosomes in neutrophil regulation remains unclear. METHODS We investigated the effects of gastric cancer cell-derived exosomes (GC-Ex) on the pro-tumor activation of neutrophils and elucidated the underlying mechanisms. RESULTS GC-Ex prolonged neutrophil survival and induced expression of inflammatory factors in neutrophils. GC-Ex-activated neutrophils, in turn, promoted gastric cancer cell migration. GC-Ex transported high mobility group box-1 (HMGB1) that activated NF-κB pathway through interaction with TLR4, resulting in an increased autophagic response in neutrophils. Blocking HMGB1/TLR4 interaction, NF-κB pathway, and autophagy reversed GC-Ex-induced neutrophil activation. Silencing HMGB1 in gastric cancer cells confirmed HMGB1 as a key factor for GC-Ex-mediated neutrophil activation. Furthermore, HMGB1 expression was upregulated in gastric cancer tissues. Increased HMGB1 expression was associated with poor prognosis in patients with gastric cancer. Finally, gastric cancer tissue-derived exosomes acted similarly as exosomes derived from gastric cancer cell lines in neutrophil activation. CONCLUSION We demonstrate that gastric cancer cell-derived exosomes induce autophagy and pro-tumor activation of neutrophils via HMGB1/TLR4/NF-κB signaling, which provides new insights into mechanisms for neutrophil regulation in cancer and sheds lights on the multifaceted role of exosomes in reshaping tumor microenvironment. | [
0.011127911508083344,
-0.0002450559986755252,
0.003178722457960248,
0.020036211237311363,
0.011716513894498348,
-0.0306757353246212,
0.011467878706753254,
0.00240018917247653,
-0.012444105930626392,
-0.00796487182378769,
0.00015697599155828357,
0.005759590305387974,
-0.00044847093522548676,
0.009589354507625103,
-0.02397887222468853,
0.023825611919164658,
-0.004696638323366642,
-0.00869837962090969,
0.007190634496510029,
0.008107699453830719,
0.032908931374549866,
-0.004578802734613419,
0.009256979450583458,
-0.005407748743891716,
0.006871804594993591,
0.007071190048009157,
0.0007809451781213284,
-0.0009551718831062317,
0.00046077242586761713,
0.03764036297798157,
-0.0012469978537410498,
0.0005455422797240317,
0.03574226796627045,
-0.02763587422668934,
0.00497172586619854,
-0.020784102380275726,
0.0008850497542880476,
0.024955904111266136,
0.0037230306770652533,
-0.003357386216521263,
-0.0006874348036944866,
-0.003746247850358486,
0.0005983678274787962,
-0.01894547790288925,
-0.0070564658381044865,
0.009932417422533035,
0.0007910509593784809,
-0.0054376740008592606,
-0.013705904595553875,
-0.0015129133826121688,
-0.004598812200129032,
-0.010599600151181221,
-0.008543400093913078,
0.01250370778143406,
-0.006337131839245558,
-0.022794267162680626,
0.0178094282746315,
-0.022178012877702713,
-0.012121425941586494,
0.009267856366932392,
0.0041253757663071156,
-0.015583028085529804,
-0.023715846240520477,
-0.016769450157880783,
0.006763812154531479,
-0.06699660420417786,
0.015246953815221786,
0.03129139542579651,
-0.002165371086448431,
-0.015773240476846695,
0.006061302497982979,
0.007959133945405483,
0.013782219961285591,
-0.004166032653301954,
-0.010117133148014545,
0.018185533583164215,
-0.01589963212609291,
0.011512873694300652,
0.007774936035275459,
0.02615009993314743,
-0.0031386478804051876,
-0.007543591316789389,
-0.03768379986286163,
0.001919975969940424,
0.001587812090292573,
0.002754064043983817,
-0.00769458431750536,
-0.00721751619130373,
0.001463040942326188,
0.006359063554555178,
0.0009090355597436428,
-0.008277586661279202,
-0.01634577289223671,
0.003292032517492771,
0.002853202633559704,
0.0032662106677889824,
-0.015938501805067062,
-0.01038490328937769,
-0.019979797303676605,
-0.03098243661224842,
-0.0010439344914630055,
0.0064466120675206184,
0.012750821188092232,
0.014457639306783676,
-0.008712190203368664,
0.008482290431857109,
0.0060492646880447865,
-0.005677336361259222,
0.015806248411536217,
0.013115712441504002,
-0.012529945001006126,
-0.002831346821039915,
-0.0008710089605301619,
0.01623464561998844,
0.007629400119185448,
0.0027396397199481726,
0.0038938350044190884,
0.010185986757278442,
0.013342145830392838,
0.028107214719057083,
0.008270950987935066,
0.0001332343090325594,
0.0113047631457448,
-0.00947206374257803,
0.009641196578741074,
0.000018181861378252506,
-0.004563797730952501,
-0.013452881947159767,
-0.0020920063834637403,
-0.00033204175997525454,
-0.008582063019275665,
-0.0002499512629583478,
0.019573424011468887,
0.01057727262377739,
-0.00782399158924818,
-0.006243875250220299,
-0.008456212468445301,
-0.008201363496482372,
0.01329816970974207,
-0.01990925334393978,
-0.0348670668900013,
0.00856558047235012,
0.004979235120117664,
0.01274842955172062,
0.02344842255115509,
0.01842065155506134,
-0.009662562981247902,
-0.0103346211835742,
-0.03237332031130791,
-0.02938474714756012,
0.003440944943577051,
-0.005216329824179411,
0.018054980784654617,
-0.0007637161761522293,
0.04774634912610054,
-0.010306397452950478,
-0.00424310564994812,
-0.007181078661233187,
0.003710667137056589,
-0.018457412719726562,
-0.039892103523015976,
-0.0193621926009655,
0.027234327048063278,
0.008139174431562424,
-0.0063787829130887985,
-0.014914678409695625,
0.036905352026224136,
0.00027510221116244793,
0.013370281085371971,
0.004330207593739033,
-0.008374456316232681,
0.006095103919506073,
0.011081712320446968,
0.01124042458832264,
0.011312983930110931,
0.007964065298438072,
0.018666673451662064,
0.00760083831846714,
-0.010220978409051895,
0.06674856692552567,
-0.006961311679333448,
0.025813424959778786,
0.013002332299947739,
0.000529174692928791,
-0.0026805256493389606,
-0.006895005702972412,
0.015766190364956856,
-0.007602125406265259,
0.01755223236978054,
-0.022906335070729256,
-0.007749998942017555,
0.027555791661143303,
-0.026273883879184723,
0.0177745521068573,
-0.02843073569238186,
0.003629359882324934,
0.008726734668016434,
0.00043550023110583425,
0.00831286795437336,
-0.020468581467866898,
0.01689900830388069,
-0.026390574872493744,
-0.0029070498421788216,
-0.008810583502054214,
-0.012156649492681026,
0.011444062925875187,
-0.020856507122516632,
-0.03052390366792679,
0.012703579850494862,
-0.000007018912583589554,
0.006260746158659458,
-0.013225090689957142,
-0.0056455256417393684,
0.00214689364656806,
0.01910952478647232,
0.006740535143762827,
0.010653724893927574,
0.012260979041457176,
0.009542640298604965,
-0.015009032562375069,
-0.004418652039021254,
0.002957578282803297,
0.02570670284330845,
-0.002488505095243454,
0.04626739025115967,
-0.013200308196246624,
0.013078237883746624,
0.010966852307319641,
0.014910531230270863,
0.00759404432028532,
-0.009862326085567474,
-0.03919517993927002,
-0.010381964966654778,
0.005949855782091618,
-0.007770563941448927,
0.025279484689235687,
0.00951540470123291,
-0.02526937797665596,
0.006466940511018038,
-0.009877016767859459,
0.01027705054730177,
0.020941756665706635,
0.026239877566695213,
-0.014595708809792995,
-0.00046378548722714186,
-0.0006449832580983639,
0.02650533989071846,
0.0034998878836631775,
0.016950972378253937,
-0.0036184056662023067,
0.007356605492532253,
0.015188385732471943,
0.007495769765228033,
-0.006782840937376022,
0.03351379558444023,
-0.012805654667317867,
-0.014110874384641647,
-0.007959451526403427,
0.023783136159181595,
0.003530937246978283,
0.002289152704179287,
0.007398132234811783,
-0.016589123755693436,
0.009983477182686329,
0.004955625161528587,
0.02694215252995491,
0.008864077739417553,
0.007572324946522713,
0.026071153581142426,
0.009378517977893353,
0.010412161238491535,
0.00183586566708982,
0.011976812034845352,
-0.08156725764274597,
-0.013460046611726284,
0.007986584678292274,
-0.006127510219812393,
0.01244470477104187,
-0.00508129270747304,
0.04267174378037453,
0.006867371033877134,
-0.00032942515099421144,
-0.025743069127202034,
-0.023366931825876236,
-0.013169837184250355,
-0.015476910397410393,
0.012670738622546196,
0.02321656420826912,
-0.008346321061253548,
0.013288458809256554,
-0.019330527633428574,
-0.003482787637040019,
-0.025604600086808205,
0.0011686560465022922,
0.010293535888195038,
0.020566724240779877,
0.006067043170332909,
-0.01717202551662922,
0.03348871320486069,
0.00037584034726023674,
0.005857563577592373,
-0.0021346937865018845,
0.007586010731756687,
-0.01296977698802948,
0.015616674907505512,
0.01856062188744545,
0.018764322623610497,
0.020346883684396744,
0.030783554539084435,
0.011751605197787285,
-0.006280126515775919,
-0.006422585342079401,
0.023579983040690422,
-0.011468864977359772,
0.02020493894815445,
0.010318592190742493,
0.015803910791873932,
0.0016784747131168842,
0.00820096768438816,
0.014583521522581577,
0.0018585071666166186,
0.016423428431153297,
0.00043944455683231354,
-0.003276833798736334,
0.006837985012680292,
0.03794584423303604,
0.015036595985293388,
-0.0165804922580719,
0.011745410971343517,
-0.01548479963093996,
-0.003390879835933447,
-0.015092817135155201,
-0.0030204695649445057,
-0.005318440031260252,
-0.02129674330353737,
0.0022988743148744106,
-0.0045433794148266315,
-0.0013931805733591318,
0.00948828924447298,
0.024205004796385765,
0.007708924822509289,
-0.018555182963609695,
0.005729369353502989,
0.02341422438621521,
-0.03225938230752945,
-0.006869839504361153,
-0.004761780612170696,
-0.03397044166922569,
-0.007010425440967083,
-0.006246223580092192,
-0.00510880071669817,
-0.02078728750348091,
-0.02353006601333618,
-0.040227945894002914,
-0.01068941317498684,
-0.048596158623695374,
-0.02263406477868557,
-0.01365594007074833,
-0.01616198755800724,
0.00628903741016984,
0.017525212839245796,
0.008291325531899929,
-0.0166759230196476,
0.00020583439618349075,
-0.003304854966700077,
-0.0014891510363668203,
0.006355631165206432,
0.0026110028848052025,
-0.009721765294671059,
0.00832715816795826,
0.0025961892679333687,
0.03057357668876648,
0.009532994590699673,
-0.01954096183180809,
-0.00010173185728490353,
0.018545977771282196,
-0.013250923715531826,
-0.03824716433882713,
0.011835549958050251,
0.01883242279291153,
0.0005350001156330109,
-0.0016483406070619822,
0.00015117786824703217,
-0.031642086803913116,
-0.010450146161019802,
-0.0074266111478209496,
-0.013070850633084774,
0.005832527298480272,
0.009311328642070293,
0.0030535622499883175,
-0.032942287623882294,
0.0721522718667984,
-0.009433153085410595,
0.0027287984266877174,
-0.009204096160829067,
0.012657362967729568,
-0.020829282701015472,
-0.029546167701482773,
-0.0026061832904815674,
-0.013711832463741302,
0.010936595499515533,
0.011885762214660645,
0.019145388156175613,
0.019886068999767303,
-0.00807566475123167,
0.0036312262527644634,
-0.00145974091719836,
-0.010190758854150772,
0.0032446046825498343,
-0.007251772563904524,
-0.004776701331138611,
-0.003907341044396162,
-0.008100811392068863,
0.0003982339985668659,
-0.0056117502972483635,
-0.012231660075485706,
-0.022105716168880463,
0.005114490166306496,
-0.013784576207399368,
-0.0033113101962953806,
0.00797494687139988,
0.01451804768294096,
-0.010851075872778893,
-0.006981831509619951,
0.007151516154408455,
0.01448952779173851,
0.006188776809722185,
-0.014187214896082878,
-0.020725905895233154,
0.004016968887299299,
0.0084000825881958,
-0.011319600977003574,
-0.012737559154629707,
-0.014336885884404182,
0.016777455806732178,
-0.028340579941868782,
-0.014059512875974178,
0.017036601901054382,
-0.008794913068413734,
0.0010701194405555725,
-0.013963032513856888,
-0.011467757634818554,
0.008524413220584393,
0.01474237721413374,
-0.008194335736334324,
-0.014588315039873123,
-0.015425432473421097,
0.006674353964626789,
-0.0019973861053586006,
0.0016839937306940556,
0.008351567201316357,
0.008245560340583324,
0.025008507072925568,
0.0051246872171759605,
0.006755960173904896,
0.027078736573457718,
-0.00654127262532711,
-0.003043718170374632,
-0.006601412780582905,
0.0230880007147789,
-0.026518963277339935,
-0.004593122750520706,
0.017677005380392075,
-0.04421897232532501,
0.009697246365249157,
0.004864097572863102,
-0.017860151827335358,
0.012394989840686321,
-0.012497322633862495,
0.024136686697602272,
-0.018941499292850494,
0.027614381164312363,
0.01143466867506504,
0.01470865122973919,
-0.007274380885064602,
0.005115787032991648,
-0.0020479531958699226,
-0.007100277580320835,
-0.07445456087589264,
-0.011419096030294895,
0.0033676759339869022,
-0.0014899979578331113,
0.01590743288397789,
-0.02824309468269348,
-0.01035534217953682,
-0.008134447038173676,
0.0066710882820189,
-0.0046909283846616745,
-0.0033500920981168747,
0.0054008010774850845,
0.01682668924331665,
0.0037902365438640118,
0.011151171289384365,
-0.013993438333272934,
0.0036275398451834917,
-0.021985003724694252,
-0.014620248228311539,
-0.015353149734437466,
0.007787015754729509,
0.012261553667485714,
-0.011116789653897285,
-0.00542477797716856,
0.009812808595597744,
-0.08102519810199738,
-0.007195066194981337,
0.007113705854862928,
-0.01959744095802307,
-0.0025149881839752197,
-0.0019133344758301973,
-0.016084257513284683,
-0.004380763508379459,
0.008106878958642483,
-0.016040287911891937,
0.019316628575325012,
0.012674225494265556,
0.006990581750869751,
-0.003452043514698744,
-0.02194363623857498,
-0.005508014932274818,
0.001988698961213231,
-0.019626766443252563,
-0.025354331359267235,
0.014364137314260006,
-0.018767179921269417,
-0.009212400764226913,
-0.010526875033974648,
-0.022399865090847015,
-0.012480564415454865,
0.0007989571895450354,
-0.000772543135099113,
0.009655720554292202,
0.006242828443646431,
0.006245277356356382,
0.0015225316165015101,
0.014402727596461773,
-0.007228198926895857,
-0.04770167917013168,
0.005187253467738628,
-0.024425318464636803,
-0.006164893973618746,
-0.0021479083225131035,
-0.00618887459859252,
0.006267646327614784,
-0.007979817688465118,
0.00638372590765357,
-0.02961447648704052,
0.024511167779564857,
-0.0002797436900436878,
0.00029157334938645363,
0.006238277535885572,
-0.003431961638852954,
0.0025954183656722307,
0.003958391956984997,
0.01196520496159792,
0.01106717437505722,
0.012371707707643509,
0.004735621158033609,
0.0068648154847323895,
0.013608709909021854,
0.00288870045915246,
-0.000551669392734766,
0.0010392619296908379,
0.012520047836005688,
-0.008165097795426846,
0.007848521694540977,
-0.004138687159866095,
0.07191112637519836,
0.02700422704219818,
0.022389018908143044,
-0.006557620130479336,
0.001469114562496543,
0.002379415323957801,
-0.011853048577904701,
-0.008621500805020332,
0.005807410925626755,
0.011180605739355087,
0.031191403046250343,
-0.002724751830101013,
-0.0038752665277570486,
0.011073252186179161,
-0.009626457467675209,
-0.0021895000245422125,
0.00861846748739481,
0.019944150000810623,
0.008923730812966824,
0.019643088802695274,
0.017875559628009796,
-0.013679930940270424,
-0.018291208893060684,
0.014140812680125237,
-0.002879281295463443,
-0.003122506197541952,
-0.02198968082666397,
0.012860527262091637,
-0.006572139449417591,
0.0059420159086585045,
-0.0034366827458143234,
0.004291071556508541,
-0.001272284658625722,
0.00986934918910265,
0.0359090194106102,
-0.004643491469323635,
-0.020064452663064003,
0.003191190306097269,
-0.012835636734962463,
0.005340516101568937,
0.0016141636297106743,
-0.0005577916745096445,
0.0014262425247579813,
-0.017269868403673172,
0.004697670228779316,
-0.0042693885043263435,
0.00848806370049715,
-0.012995153665542603,
-0.01445741392672062,
0.01761399395763874,
0.013228761032223701,
0.010807262733578682,
0.007606258615851402,
0.003699658904224634,
0.009936666116118431,
-0.024308795109391212,
-0.008377019315958023,
0.008097977377474308,
-0.010187814012169838,
-0.004971486050635576,
0.012575406581163406,
-0.024781769141554832,
0.016412746161222458,
-0.014517039991915226,
0.0009838733822107315,
-0.00506624486297369,
0.014383462257683277,
-0.010044608265161514,
-0.02499832957983017,
0.019999142736196518,
0.01028054766356945,
-0.006355328019708395,
0.008486263453960419,
-0.012185594066977501,
0.004022654145956039,
0.016975272446870804,
-0.010844670236110687,
-0.0058616274036467075,
0.014655699953436852,
0.012181827798485756,
-0.012342595495283604,
0.037856575101614,
-0.016347605735063553,
0.031961068511009216,
-0.041569799184799194,
0.030427105724811554,
0.0033537684939801693,
-0.0008449268061667681,
-0.00023727078223600984,
0.013821718282997608,
0.04246009141206741,
-0.010547028854489326,
0.00005590959335677326,
0.040755968540906906,
0.009915217757225037,
0.03366986662149429,
-0.0030416129156947136,
-0.003122275695204735,
0.016382861882448196,
0.01594601757824421,
0.014872103929519653,
0.010507272556424141,
-0.01891760341823101,
0.0015995313879102468,
-0.01030088122934103,
-0.0026486327406018972,
0.012194870039820671,
-0.01758454367518425,
-0.001394936814904213,
-0.005725174676626921,
-0.007856566458940506,
-0.017269592732191086,
-0.002066709566861391,
0.018523771315813065,
-0.009142347611486912,
0.011481806635856628,
-0.0221675056964159,
0.03123817779123783,
-0.007066098041832447,
-0.011270007118582726,
-0.003810435999184847,
-0.02138689160346985,
-0.008294647559523582,
0.014203889295458794,
-0.019658833742141724,
-0.010566544719040394,
-0.011311725713312626,
0.02089596912264824,
-0.005692573264241219,
-0.014802251011133194,
0.012065413407981396,
-0.033858709037303925,
0.006327003240585327,
0.012457655742764473,
-0.010905886068940163,
0.004140560049563646,
-0.0003293821355327964,
0.024489877745509148,
-0.003074787789955735,
0.0031553353182971478,
0.007718442939221859,
-0.025877082720398903,
0.00634168554097414,
-0.00469929538667202,
0.0077643622644245625,
-0.015490222722291946,
0.012186960317194462,
-0.005842115730047226,
0.004901697393506765,
-0.006199982017278671,
0.011428510770201683,
0.0033907939214259386,
-0.02524763159453869,
-0.005154484882950783,
0.0011606733314692974,
0.024640683084726334,
-0.016857661306858063,
-0.00011239061132073402,
0.005540377460420132,
-0.0016002114862203598,
0.005194956436753273,
0.003514947136864066,
0.032113488763570786,
0.00044350698590278625,
-0.005495931021869183,
0.0001707235351204872,
0.012135754339396954,
-0.008508623577654362,
-0.011126922443509102,
0.0012784479185938835,
0.02510012872517109,
-0.0004571598256006837,
-0.015950703993439674,
0.013007039204239845,
-0.025895703583955765,
-0.005906142294406891,
-0.0010436358861625195,
-0.01888609305024147,
0.012469686567783356,
-0.0164291113615036,
0.006804391276091337,
-0.014903406612575054,
0.00010040169581770897,
-0.001973953330889344,
-0.004135564900934696,
-0.02430274710059166,
-0.0035747522488236427,
-0.005432898178696632,
-0.002523932373151183,
-0.005756393074989319,
-0.003653507912531495,
-0.021115882322192192,
-0.00441907811909914,
0.023198049515485764,
0.005073980428278446,
0.0029122268315404654,
0.02791900932788849,
-0.0075642503798007965,
0.01822623237967491,
0.017625315114855766,
0.0005964001175016165,
-0.013262800872325897
] | [
0.32786232233047485,
-0.14951100945472717,
0.6432722806930542,
0.2467581182718277,
0.16199523210525513,
0.1297847330570221,
-0.01445028930902481,
0.43126991391181946,
-0.0027321972884237766,
-0.4765467941761017,
-0.26074743270874023,
0.4217958152294159,
-0.48956888914108276,
0.08926937729120255,
-0.12005843967199326,
0.1757485717535019,
0.45086535811424255,
0.3001905679702759,
-0.2960538864135742,
-0.8069547414779663,
-0.39264410734176636,
-0.17454396188259125,
0.38225728273391724,
0.08520908653736115,
0.6524172425270081,
-0.1340271383523941,
-0.013157743029296398,
0.030389996245503426,
0.6359268426895142,
-0.0891856998205185,
0.279089093208313,
0.5825982093811035,
0.032777830958366394,
-0.11279890686273575,
-0.1442953646183014,
-0.23493243753910065,
-0.1674903929233551,
0.09903926402330399,
-0.12085411697626114,
-0.028676575049757957,
-0.4684348404407501,
-0.041754238307476044,
-0.2774449288845062,
0.37873971462249756,
-0.1546027809381485,
-0.23328730463981628,
-1.0890934467315674,
0.5875311493873596,
-0.08423278480768204,
-0.0008678024169057608,
0.014822861179709435,
0.3267460763454437,
0.27776283025741577,
0.41824236512184143,
-0.027945447713136673,
-0.09448914974927902,
-0.5289715528488159,
-0.2967255711555481,
0.17840541899204254,
-0.7150200605392456,
-0.14833523333072662,
0.08843016624450684,
-0.3316193222999573,
-0.20140329003334045,
-0.26828113198280334,
0.166094109416008,
0.022653434425592422,
-0.5989105701446533,
-0.08326026797294617,
-0.08378054201602936,
-0.0624283030629158,
0.005493896547704935,
-0.06104271858930588,
0.012075531296432018,
-0.11549761891365051,
0.30179592967033386,
0.07857789099216461,
0.0820317268371582,
0.38662755489349365,
-0.1715719848871231,
-0.16559912264347076,
0.053817495703697205,
0.18441380560398102,
-0.378542423248291,
0.45395490527153015,
0.15099196135997772,
-0.30222633481025696,
0.4662449359893799,
-0.25669366121292114,
-0.07589472830295563,
-0.4470283091068268,
-0.2523500323295593,
0.21593698859214783,
0.34691429138183594,
0.06277236342430115,
0.4774329960346222,
0.19056907296180725,
-0.4447634518146515,
0.14521603286266327,
0.16557280719280243,
-0.4696061313152313,
0.1248764768242836,
0.053449664264917374,
-0.5101901292800903,
-0.6500845551490784,
-0.0883098840713501,
-0.1523800641298294,
-0.20351436734199524,
-0.6505730152130127,
0.4979385435581207,
-0.788539469242096,
-0.25503140687942505,
-0.1099109873175621,
-0.19244080781936646,
0.023444000631570816,
-0.011699633672833443,
-0.09718950092792511,
-0.24832016229629517,
0.23452043533325195,
0.3999747037887573,
-0.06858491152524948,
1.1523513793945312,
-0.13330583274364471,
0.17557130753993988,
0.08108411729335785,
0.27678215503692627,
0.2750483751296997,
-0.11415572464466095,
-0.11938317120075226,
0.6806265711784363,
0.18322879076004028,
0.7619996666908264,
-0.44379568099975586,
0.36104816198349,
0.21053701639175415,
-0.1912376582622528,
0.6213061809539795,
0.27781951427459717,
0.33982130885124207,
0.47101253271102905,
-0.6825655102729797,
-0.5766791701316833,
0.02836797758936882,
0.08664646744728088,
0.21891431510448456,
-0.511614203453064,
-0.5227321982383728,
-0.3885939419269562,
0.06279490143060684,
-0.33441048860549927,
-0.16448748111724854,
-0.4584798812866211,
-0.4206978678703308,
-0.24625490605831146,
-0.10274140536785126,
0.4513852894306183,
0.14778614044189453,
-0.008237556554377079,
-0.17619499564170837,
0.14260496199131012,
0.3150928020477295,
0.3204288184642792,
-0.23584844172000885,
0.009607229381799698,
0.7511191964149475,
-0.16773633658885956,
0.05280676484107971,
0.10964546352624893,
-0.264204740524292,
0.36400067806243896,
-0.11255988478660583,
-0.2952534258365631,
-0.07644053548574448,
-0.857607364654541,
0.09890058636665344,
0.30066534876823425,
0.16647876799106598,
0.09558302164077759,
-0.06824007630348206,
-0.24248503148555756,
-0.6991407871246338,
0.32624757289886475,
-0.11269394308328629,
-0.7380923628807068,
0.00969055388122797,
0.10558120161294937,
0.35609832406044006,
-0.23019158840179443,
0.0919477716088295,
-0.4018920063972473,
-0.34445223212242126,
-0.052874837070703506,
0.6771513819694519,
-0.7241708636283875,
1.6673823595046997,
-0.57410728931427,
0.2736019492149353,
0.9412756562232971,
0.21827761828899384,
-0.30263277888298035,
0.22316060960292816,
-0.19861850142478943,
0.8547544479370117,
-0.40989166498184204,
-0.31286871433258057,
0.2716805040836334,
0.05682067945599556,
-0.3335605561733246,
0.2681093215942383,
-0.26594701409339905,
0.30757591128349304,
0.03743073344230652,
-0.06240631267428398,
-0.13681918382644653,
0.3241223394870758,
-0.49706581234931946,
-0.4273313879966736,
0.0038650683127343655,
-0.19604110717773438,
-0.1787939816713333,
0.3199009597301483,
-0.6646584272384644,
0.45245543122291565,
0.9908604025840759,
-0.393224835395813,
0.5370895862579346,
0.47066742181777954,
0.23181745409965515,
0.7372581958770752,
-0.0709468349814415,
0.19471943378448486,
-0.21390430629253387,
-0.24988175928592682,
-0.4910033345222473,
-0.17442762851715088,
-0.04463193565607071,
0.17240390181541443,
0.1521521359682083,
-0.14566724002361298,
-0.001341428724117577,
-0.2783348560333252,
0.39654892683029175,
-1.102291226387024,
-0.07747464627027512,
-0.3487609624862671,
-0.3908185362815857,
-0.609138011932373,
0.15391524136066437,
-0.8290855288505554,
-0.09000419080257416,
-0.042435240000486374,
0.32302844524383545,
0.06152941286563873,
-0.5289461016654968,
0.15665926039218903,
0.12643232941627502,
-0.11336492002010345,
-0.26543325185775757,
0.12862390279769897,
-0.3804425597190857,
-0.07118474692106247,
0.19595538079738617,
0.009126554243266582,
0.6007325649261475,
-0.06613437086343765,
-0.45486560463905334,
-0.21339944005012512,
-0.3464542627334595,
0.8144468665122986,
0.437943696975708,
0.6005326509475708,
-0.11065349727869034,
-0.5079436898231506,
-0.0033604740165174007,
0.008244536817073822,
-0.6715506911277771,
0.2740132212638855,
0.6370306015014648,
0.023948032408952713,
-0.4452075958251953,
-0.10261858999729156,
0.09992242604494095,
0.7001434564590454,
0.13321490585803986,
-0.039184700697660446,
-0.293530136346817,
-0.37940534949302673,
0.22593648731708527,
-0.17987149953842163,
-0.1421964019536972,
-0.14162804186344147,
0.3339764177799225,
-0.225648894906044,
-0.17587779462337494,
0.5164029002189636,
0.5429223775863647,
0.058333009481430054,
0.48908665776252747,
0.42542314529418945,
0.16701601445674896,
-0.004119915422052145,
0.5014787912368774,
0.21921402215957642,
-0.003383717965334654,
-0.2886165976524353,
-0.16939061880111694,
-0.5807765126228333,
0.3429040014743805,
-5.923331260681152,
0.36206886172294617,
0.019284168258309364,
-0.4214164614677429,
0.0145724443718791,
-0.028553498908877373,
0.9648240208625793,
0.12197832018136978,
0.4107888340950012,
0.058666471391916275,
0.07405837625265121,
0.5068050622940063,
-0.28034013509750366,
0.20756080746650696,
0.02378802001476288,
-0.0689888745546341,
-0.2993636727333069,
-0.41173484921455383,
0.6035528779029846,
0.29063883423805237,
0.11755403131246567,
-0.03819727152585983,
0.5529749989509583,
0.45994603633880615,
0.2531675100326538,
0.023774398490786552,
-1.0843240022659302,
0.1599455624818802,
0.11607987433671951,
-0.23235510289669037,
0.18925076723098755,
-0.7551860213279724,
0.1138441190123558,
-0.10763174295425415,
0.5885061621665955,
0.08111250400543213,
0.06783489882946014,
0.15435662865638733,
0.04999964311718941,
-0.48292076587677,
0.18262198567390442,
0.4126345217227936,
-0.3522103726863861,
-0.04145190492272377,
0.15383106470108032,
0.2261199802160263,
-0.07270877063274384,
0.24919100105762482,
-0.2945036292076111,
1.2527494430541992,
-0.07817427814006805,
-0.03688635304570198,
0.19639980792999268,
0.3316853940486908,
0.5123227834701538,
0.2844054102897644,
-0.054806508123874664,
-0.137915700674057,
-0.3537138104438782,
0.12108349055051804,
-0.22457294166088104,
0.022805314511060715,
-0.29735589027404785,
-0.5705432891845703,
0.32808488607406616,
0.3079802691936493,
-1.3072831630706787,
-0.2997846305370331,
0.6119471788406372,
-0.21261897683143616,
0.09805866330862045,
0.13026313483715057,
0.2251025289297104,
-0.7200881242752075,
0.1875281035900116,
-0.4972572922706604,
0.08262069523334503,
0.060086801648139954,
0.6606823205947876,
-0.04524191841483116,
-0.1482541561126709,
0.20604479312896729,
-0.01024012453854084,
-0.24239110946655273,
-0.06381943076848984,
-0.02185795269906521,
-0.3990820348262787,
-0.35431042313575745,
-0.18752428889274597,
0.19681519269943237,
0.6746509671211243,
-0.5895493030548096,
-0.0745241567492485,
0.5905086398124695,
0.616995632648468,
0.3562779724597931,
0.5595019459724426,
0.7405051589012146,
0.267879843711853,
-0.07766982167959213,
1.0607104301452637,
-0.31161707639694214,
-0.511037290096283,
-0.9196338653564453,
-0.17002350091934204,
0.05187755078077316,
-0.8989984393119812,
0.29655712842941284,
0.6036084294319153,
-0.6969612240791321,
0.21109899878501892,
-0.12416743487119675,
-0.4021361470222473,
-0.4731285274028778,
0.3775161802768707,
0.038771118968725204,
-0.06603139638900757,
-0.07897394150495529,
0.6993984580039978,
-0.518420934677124,
0.3616122007369995,
0.6125850081443787,
0.020544186234474182,
0.49910953640937805,
-0.2690397799015045,
-0.13217788934707642,
0.266304075717926,
0.5960309505462646,
-0.8631288409233093,
-0.15435998141765594,
0.026208363473415375,
0.0360846184194088,
-0.2908179461956024,
-0.005875454284250736,
0.2689987123012543,
-0.48060017824172974,
-0.30219149589538574,
0.3620172142982483,
0.5400775074958801,
0.07616827636957169,
0.0038839871995151043,
-0.29362794756889343,
-0.27547192573547363,
0.05193687975406647,
0.48918500542640686,
-0.11464091390371323,
-0.4045124053955078,
0.2289324253797531,
0.049139853566884995,
-0.0901087149977684,
0.2518293857574463,
-0.09753359109163284,
0.3359246850013733,
-0.05937706306576729,
-0.20046564936637878,
0.07524935156106949,
0.27069178223609924,
-0.14026953279972076,
-0.0065412805415689945,
-0.5297589898109436,
0.6229643225669861,
0.22044911980628967,
-0.754407525062561,
-0.032973553985357285,
-0.09094402194023132,
-0.5351352691650391,
-0.2773789167404175,
-0.6676923036575317,
-0.04339400678873062,
-0.016717826947569847,
-0.255866140127182,
-0.21214312314987183,
-0.33143988251686096,
-0.24167075753211975,
0.16788332164287567,
-0.16072919964790344,
-0.34366393089294434,
0.31629326939582825,
0.041602157056331635,
0.16722114384174347,
0.015635162591934204,
-0.361446350812912,
-0.2821410894393921,
-0.11352594941854477,
0.7105960845947266,
0.389818400144577,
0.333432137966156,
0.008507350459694862,
0.2039860039949417,
-0.31261786818504333,
0.3341687321662903,
0.03613681718707085,
-0.011085601523518562,
-0.3313773274421692,
0.22560934722423553,
0.11282020062208176,
0.017171291634440422,
0.4918302893638611,
0.2383263260126114,
-0.48067885637283325,
0.13086862862110138,
0.4994238317012787,
-0.34544169902801514,
0.5080079436302185,
0.20296671986579895,
0.08871444314718246,
0.06246396154165268,
-0.2149042785167694,
-0.06226366013288498,
-0.01054433360695839,
0.012321431189775467,
-0.46583452820777893,
0.05566858500242233,
0.4763203561306,
-0.3491251766681671,
-0.06741682440042496,
0.0013923621736466885,
-0.365639865398407,
-0.42233985662460327,
0.40933623909950256,
0.26489076018333435,
-0.23598720133304596,
-0.09205586463212967,
0.19268466532230377,
-0.18851542472839355,
0.33531323075294495,
0.5818492770195007,
-0.6093745827674866,
0.23228254914283752,
-0.09370003640651703,
-0.556709349155426,
0.28535014390945435,
0.4443590044975281,
0.10875725001096725,
-0.5631946325302124,
-0.08424928784370422,
-0.2771832346916199,
-0.08697532117366791,
-0.12649467587471008,
0.5748069882392883,
0.3726659119129181,
0.36879098415374756,
-0.6355729103088379,
-0.7298475503921509,
0.18514887988567352,
1.1617637872695923,
0.2845889627933502,
-0.5947220325469971,
-0.1891631931066513,
-0.47000181674957275,
0.8913018703460693,
-0.24385233223438263,
-0.08315244317054749,
0.4885292649269104,
0.432475745677948,
-0.29083725810050964,
-0.5025638341903687,
0.138061061501503,
0.029047399759292603,
0.18015465140342712,
-0.05082709714770317,
-0.4660760760307312,
-0.27145907282829285,
0.023092001676559448,
0.4154980778694153,
-0.23909686505794525,
0.044793590903282166,
-0.2672085464000702,
-0.06416551023721695,
0.0528327040374279,
0.2574802041053772,
-0.4883747100830078,
1.1260193586349487,
0.5384791493415833,
0.003953342791646719,
0.1624109297990799,
-0.5875666737556458,
0.17996977269649506,
-0.3784139156341553,
0.08792514353990555,
-0.5313504338264465,
-0.654689610004425,
0.2012190967798233,
-0.1735456883907318,
0.5715824961662292,
-0.8337116241455078,
0.28686052560806274,
-0.31540966033935547,
-0.04818205162882805,
-0.6076521873474121,
-0.3766065239906311,
-0.07484797388315201,
-0.6992038488388062,
-0.3088603913784027,
0.04576990753412247,
0.08506946265697479,
0.0705021396279335,
0.358693391084671,
0.7996082901954651,
0.16947965323925018,
-0.6944495439529419,
0.4654408395290375,
0.5505533814430237,
-0.4920122027397156,
0.5480167269706726,
0.5307878851890564,
-0.06793807446956635,
-0.4048073887825012,
-0.3355673551559448,
-0.2949495017528534,
-0.1840612143278122,
-0.2691954970359802,
-0.04648532718420029,
0.08199819177389145,
-0.28726276755332947,
-0.13347911834716797,
-0.4230758547782898,
-0.5443025231361389,
0.6398987174034119,
0.33678117394447327,
0.5357498526573181,
1.065929651260376,
0.452602356672287,
0.27089476585388184,
-0.08646828681230545,
0.5156790018081665,
0.16728974878787994,
0.06391199678182602,
0.011470242403447628,
0.1769339144229889,
0.7899799942970276,
0.6157436370849609,
0.005383646115660667,
0.23975415527820587,
0.3162967562675476,
0.03567953407764435,
0.21657730638980865,
-0.34456968307495117,
-0.23356199264526367,
0.0701165422797203,
0.23526769876480103,
0.10639362037181854,
-0.137616828083992,
-0.25041016936302185,
-0.109592504799366,
0.3473125100135803,
0.29342323541641235,
0.49367961287498474,
-0.18256917595863342,
0.34331434965133667,
0.19770969450473785,
-0.529123067855835,
-0.3405582904815674,
-0.1669447422027588,
-0.7223961353302002,
0.4874579906463623,
0.2487405389547348,
0.04351625218987465,
-0.70820552110672,
0.05720651522278786,
-0.5104339718818665,
0.05932379141449928,
-0.012977557256817818,
0.33378827571868896,
-0.21522371470928192,
0.32809948921203613,
0.06698094308376312,
0.07485904544591904,
0.3463256359100342,
-0.2990647554397583,
-0.22654449939727783,
-0.10961080342531204,
-0.044802457094192505,
-0.012448232620954514,
-0.1890544444322586,
-0.6919009685516357,
-0.10257964581251144,
0.14127042889595032,
0.042460113763809204,
0.37337541580200195,
-0.25960448384284973,
0.45714321732521057,
0.26473239064216614,
-0.6189830899238586,
-0.09058282524347305,
-0.4386945366859436,
-0.6398234367370605,
-0.11285828053951263,
-0.3523176610469818,
0.06083717942237854,
-0.06547687202692032,
-0.8685358762741089,
0.6103764176368713,
0.1019810289144516,
0.15378519892692566,
0.27796444296836853,
0.1887810379266739,
0.5065267086029053,
0.29620346426963806,
0.36403781175613403,
-0.18222106993198395,
0.13808941841125488,
0.013864673674106598,
0.1533922404050827,
-0.06329498440027237,
0.1830001026391983,
-0.7858405113220215,
-0.5043764114379883,
-0.478922575712204,
-0.1656779646873474,
0.5525059103965759,
0.24546606838703156,
-0.43332532048225403,
0.29470086097717285,
0.2460346221923828,
0.7160030603408813,
0.3640090823173523,
-0.13727739453315735,
-0.1489330381155014,
-0.3244676887989044,
-0.143829345703125,
-0.3851546347141266,
0.39532187581062317,
-0.12932418286800385,
0.056769419461488724,
-0.14620386064052582,
0.35213544964790344,
0.5100728273391724,
-0.1382274031639099,
0.45820629596710205,
-0.3616545796394348,
-0.5783423185348511,
-0.8518499732017517,
0.49230289459228516,
-0.2618424594402313,
0.41853249073028564,
-0.34413233399391174,
-0.05716591328382492,
0.14313636720180511,
-0.2591296434402466,
0.15298976004123688,
-0.3434920907020569,
0.468151330947876,
-0.11291921883821487,
-0.10696529597043991,
0.09772752970457077,
0.17475587129592896,
-0.5529709458351135,
-1.1163891553878784,
0.09282545745372772,
0.022328685969114304,
-1.1234084367752075,
0.1949559450149536,
-0.010588197037577629,
-0.2124413102865219,
0.019691340625286102,
0.05884634703397751,
-0.5323203802108765,
-0.4063573479652405,
-0.22228805720806122
] |
Actively transcribed regions of the genome are protected by transcription-coupled DNA repair mechanisms, including transcription-coupled homologous recombination (TC-HR). Here we used reactive oxygen species (ROS) to induce and characterize TC-HR at a transcribed locus in human cells. As canonical HR, TC-HR requires RAD51. However, the localization of RAD51 to damage sites during TC-HR does not require BRCA1 and BRCA2, but relies on RAD52 and Cockayne Syndrome Protein B (CSB). During TC-HR, RAD52 is recruited by CSB through an acidic domain. CSB in turn is recruited by R loops, which are strongly induced by ROS in transcribed regions. Notably, CSB displays a strong affinity for DNA:RNA hybrids in vitro, suggesting that it is a sensor of ROS-induced R loops. Thus, TC-HR is triggered by R loops, initiated by CSB, and carried out by the CSB-RAD52-RAD51 axis, establishing a BRCA1/2-independent alternative HR pathway protecting the transcribed genome. | [
0.014908857643604279,
0.015322357416152954,
-0.019714241847395897,
0.019477926194667816,
0.017991816624999046,
-0.0005000496748834848,
0.010604840703308582,
-0.012289985083043575,
-0.013144818134605885,
-0.029703307896852493,
-0.016845282167196274,
0.010504190810024738,
-0.01846848428249359,
0.01935664191842079,
-0.01584305614233017,
0.007597807794809341,
-0.013530030846595764,
0.028871843591332436,
0.018723182380199432,
0.01674577407538891,
0.010270067490637302,
-0.004044773522764444,
0.010370421223342419,
0.015666281804442406,
0.011042594909667969,
-0.00805729441344738,
0.002354783471673727,
0.00028976029716432095,
-0.010980691760778427,
0.016015883535146713,
0.0013435403816401958,
-0.01513722911477089,
0.019341478124260902,
0.05565007030963898,
-0.0006731931352987885,
-0.001233567949384451,
-0.013975763693451881,
0.023038074374198914,
0.04211913049221039,
-0.006340495776385069,
-0.004486646503210068,
-0.013806706294417381,
0.013087550178170204,
0.008628823794424534,
-0.007125693839043379,
-0.002855245489627123,
-0.002754887565970421,
0.021693870425224304,
0.014122623950242996,
0.010544031858444214,
-0.008809417486190796,
-0.0029418598860502243,
-0.010754097253084183,
0.04429008811712265,
-0.005959281697869301,
0.015306579880416393,
0.019426461309194565,
0.02106761559844017,
-0.0031726937741041183,
0.016481265425682068,
0.004043441265821457,
0.005016515031456947,
0.0005981717258691788,
-0.004339954350143671,
0.01622278243303299,
-0.0669100284576416,
0.013666080310940742,
-0.0011956598609685898,
-0.00651240348815918,
0.019826598465442657,
-0.028464578092098236,
0.01400285866111517,
0.0029743490740656853,
0.0008657169528305531,
-0.017017830163240433,
-0.016238991171121597,
-0.017932940274477005,
-0.029949605464935303,
0.025965556502342224,
0.031236544251441956,
-0.020122118294239044,
-0.010321196168661118,
-0.009169445373117924,
-0.0046795448288321495,
0.0053063929080963135,
-0.0011981816496700048,
-0.0017204704927280545,
-0.002688468899577856,
-0.019514845684170723,
-0.03260219097137451,
0.007832743227481842,
0.010008851997554302,
-0.013292266987264156,
-0.005162056535482407,
-0.05014536529779434,
0.026551973074674606,
-0.005032401531934738,
-0.0001539411023259163,
0.027775980532169342,
0.012541389092803001,
-0.009031970053911209,
0.03588403761386871,
0.020371317863464355,
-0.024631738662719727,
-0.021288691088557243,
0.011541965417563915,
0.013786453753709793,
-0.006073527038097382,
0.003991249483078718,
0.007580134551972151,
-0.003700138535350561,
0.020781343802809715,
-0.013815637677907944,
0.008370965719223022,
0.018210796639323235,
0.018564801663160324,
0.0023782607167959213,
-0.01261821947991848,
0.022130558267235756,
-0.009288651868700981,
-0.03848302364349365,
-0.019928935915231705,
0.0008333032019436359,
-0.0054145557805895805,
0.0028044390492141247,
0.015494871884584427,
-0.012147698551416397,
0.010714218020439148,
0.0006384411826729774,
0.021139485761523247,
-0.010714537464082241,
0.007992878556251526,
-0.017770685255527496,
0.0024353426415473223,
0.0054356930777430534,
-0.0002554067177698016,
-0.05458933860063553,
0.002629864029586315,
-0.019123665988445282,
0.0011620577424764633,
0.01741793006658554,
0.00819358043372631,
-0.001712435856461525,
0.011166229844093323,
-0.0010602667462080717,
0.009900675155222416,
0.014501783065497875,
0.00037771696224808693,
0.025632772594690323,
-0.03613048046827316,
-0.000954075250774622,
-0.003006820334121585,
-0.01257430762052536,
-0.01579206809401512,
-0.006105638109147549,
0.021448403596878052,
-0.01545906811952591,
-0.004170358180999756,
0.0009240279323421419,
0.034226931631565094,
-0.003927594516426325,
-0.030689995735883713,
0.016538677737116814,
0.00896378792822361,
0.020938728004693985,
0.00858788751065731,
0.012571800500154495,
0.008113150484859943,
-0.00662203598767519,
0.004027995280921459,
-0.003131406381726265,
0.02694736234843731,
0.012049646116793156,
0.005933941341936588,
0.004089145455509424,
-0.0045542106963694096,
0.0020735030993819237,
0.007623607758432627,
-0.013408184051513672,
0.06677365303039551,
0.0011699930764734745,
0.0017076105577871203,
0.005024181678891182,
0.01316174678504467,
0.02026006393134594,
0.004213667940348387,
-0.01000368595123291,
0.004621569067239761,
-0.03109888918697834,
-0.012870722450315952,
0.012630056589841843,
-0.02163681387901306,
-0.04206973314285278,
-0.002095218747854233,
0.009854895994067192,
0.0021007624454796314,
-0.005829114466905594,
0.005665820557624102,
0.021352078765630722,
0.0051264287903904915,
-0.004507399629801512,
0.017975911498069763,
0.019575538113713264,
-0.012597035616636276,
0.011114979162812233,
0.0050315833650529385,
-0.012997863814234734,
0.020641159266233444,
0.012435460463166237,
0.017768852412700653,
0.030263733118772507,
-0.020282676443457603,
-0.012879795394837856,
-0.0014905263669788837,
0.0037823107559233904,
0.009574388153851032,
0.022340841591358185,
0.02396479807794094,
-0.0011298626195639372,
-0.011206559836864471,
-0.0018684100359678268,
-0.01172412745654583,
0.030008889734745026,
-0.02040245570242405,
0.028841231018304825,
0.0005550677888095379,
-0.01255851425230503,
0.0158341433852911,
-0.002782091498374939,
0.020573915913701057,
0.005786689929664135,
-0.04365257918834686,
-0.014307242818176746,
-0.0003442689776420593,
-0.00032804347574710846,
0.001831928500905633,
0.017045672982931137,
-0.008047640323638916,
0.0025773090310394764,
-0.010027904994785786,
-0.0070748887956142426,
0.015876317396759987,
-0.002979651093482971,
-0.0079667242243886,
-0.034454576671123505,
0.02162097953259945,
0.002306027337908745,
0.009962173178792,
0.02752789482474327,
-0.03707719221711159,
0.01026823092252016,
-0.027822919189929962,
0.025853639468550682,
0.013442831113934517,
0.024765625596046448,
0.009960927069187164,
0.012967693619430065,
0.0178512055426836,
0.02322213351726532,
-0.011730729602277279,
-0.0016721428837627172,
0.001166593050584197,
0.011673131957650185,
-0.020486118271946907,
-0.010280363261699677,
0.011959917843341827,
0.0009285989217460155,
0.015886586159467697,
-0.000999540090560913,
-0.004053525160998106,
0.01055840589106083,
-0.011011732742190361,
-0.006719918921589851,
-0.08139275014400482,
-0.013483746908605099,
0.006557068321853876,
-0.009659990668296814,
0.007609799969941378,
-0.011491119861602783,
-0.020377349108457565,
0.006900282576680183,
-0.013328722678124905,
0.01581132784485817,
0.008538775146007538,
0.016674570739269257,
-0.021612711250782013,
-0.009184736758470535,
-0.031209193170070648,
-0.019303379580378532,
0.00913351122289896,
-0.02471502497792244,
-0.016245577484369278,
-0.009787187911570072,
-0.0005051749758422375,
0.005030725616961718,
-0.0014844704419374466,
0.008467195555567741,
-0.003922266885638237,
-0.024368077516555786,
0.002836783416569233,
0.0032079860102385283,
0.0000349339097738266,
-0.006657435558736324,
-0.013278000988066196,
0.00426191370934248,
0.013818413950502872,
-0.012581614777445793,
-0.005033031105995178,
-0.009144208393990993,
-0.008458555676043034,
0.008036622777581215,
-0.021495746448636055,
0.010305558331310749,
0.006139624398201704,
0.005544092506170273,
0.017854809761047363,
0.005204357672482729,
0.005255354102700949,
0.03178673982620239,
-0.004276135470718145,
0.005481289699673653,
0.01763727143406868,
0.015047833323478699,
0.000542080495506525,
0.010624215006828308,
0.005286494269967079,
0.01369482185691595,
-0.00885110441595316,
0.0016033626161515713,
-0.0037800115533173084,
0.004836170468479395,
-0.006430493667721748,
-0.010503250174224377,
0.002809468423947692,
-0.02336944080889225,
-0.011292167007923126,
0.0007704566232860088,
0.017562780529260635,
-0.008077187463641167,
0.00819777324795723,
-0.010044367983937263,
-0.012774455361068249,
0.007176565006375313,
-0.0029082121327519417,
-0.004076787736266851,
-0.026012014597654343,
-0.01091625913977623,
-0.024301940575242043,
-0.010707829147577286,
-0.010429778136312962,
0.0054999147541821,
0.013410631567239761,
0.0016002857591956854,
-0.026708511635661125,
-0.004473509266972542,
-0.007518017198890448,
-0.018728511407971382,
-0.018960295245051384,
-0.016847992315888405,
0.00626179575920105,
0.007127664051949978,
0.02355152741074562,
-0.016287479549646378,
0.013525968417525291,
0.0139658497646451,
-0.011075049638748169,
0.010954316705465317,
0.004660220816731453,
-0.0390402190387249,
0.00824461504817009,
0.008678290992975235,
-0.00148738082498312,
0.010489022359251976,
-0.027787376195192337,
-0.001820718520320952,
0.0002706300001591444,
-0.005480951629579067,
0.0032484647817909718,
0.010916955769062042,
-0.0062602730467915535,
-0.007871665060520172,
-0.0017218831926584244,
-0.008396925404667854,
0.011294047348201275,
0.0005733934231102467,
-0.008268818259239197,
0.0014270611573010683,
0.014538433402776718,
0.010100318118929863,
-0.009324884042143822,
0.01267317309975624,
0.07273390889167786,
-0.016770683228969574,
0.01620294526219368,
-0.015303353779017925,
-0.01697000488638878,
-0.02599233202636242,
-0.009097978472709656,
0.0006561914924532175,
0.006141278892755508,
-0.007150216028094292,
0.011081231757998466,
-0.022415069863200188,
-0.002043873770162463,
0.000028582289814949036,
0.0008971388451755047,
0.00023759668692946434,
0.00019901618361473083,
0.03437815606594086,
0.008810079656541348,
-0.001985314302146435,
-0.025908811017870903,
-0.026327403262257576,
-0.011887426488101482,
0.018861819058656693,
-0.002936516422778368,
-0.013313937932252884,
0.021551797166466713,
-0.014815284870564938,
-0.013986228965222836,
0.01570986583828926,
0.009675441309809685,
-0.006395898759365082,
-0.008192532695829868,
0.00862315483391285,
0.0019484494114294648,
0.0149067472666502,
0.0286384429782629,
0.007903041318058968,
0.0065835705026984215,
0.02094854786992073,
0.013270709663629532,
-0.01688331551849842,
0.05425853654742241,
0.011198318563401699,
0.039996106177568436,
0.01634771004319191,
0.004532057326287031,
-0.0069008865393698215,
-0.00013962294906377792,
0.003167390823364258,
-0.01439645141363144,
-0.010228588245809078,
0.008844082243740559,
-0.0008665828499943018,
0.009019440971314907,
-0.023379508405923843,
0.03546491637825966,
-0.011611921712756157,
0.016779888421297073,
-0.016995051875710487,
-0.00991264171898365,
-0.018762456253170967,
0.02034405618906021,
-0.018521323800086975,
0.013487087562680244,
-0.012212383560836315,
-0.017800800502300262,
-0.0028534368611872196,
-0.019957607612013817,
0.01916448399424553,
-0.01175271812826395,
-0.024023214355111122,
-0.011258304119110107,
-0.029246538877487183,
-0.0031922576017677784,
-0.0025859326124191284,
0.027087925001978874,
0.023197483271360397,
-0.017290577292442322,
-0.03268338739871979,
-0.028980424627661705,
0.018766483291983604,
0.0010850029066205025,
0.005629387218505144,
0.032677631825208664,
0.007571866270154715,
-0.016434794291853905,
-0.07473553717136383,
-0.0033500713761895895,
0.010755938477814198,
-0.008120995946228504,
0.0063539608381688595,
0.027336545288562775,
-0.005964087322354317,
-0.022097425535321236,
0.011262364685535431,
-0.0070173535495996475,
-0.01978089101612568,
-0.004077580291777849,
-0.009293647482991219,
0.0017373200971633196,
0.012916825711727142,
0.00872880406677723,
0.009463053196668625,
-0.0019991209264844656,
-0.02785366028547287,
0.020981471985578537,
-0.0007201358675956726,
0.008767914026975632,
-0.000009636161848902702,
-0.012140684761106968,
0.003431458491832018,
-0.08163774013519287,
-0.02351290173828602,
0.009854328818619251,
-0.019968658685684204,
-0.011090276762843132,
-0.005277882795780897,
0.03424302488565445,
-0.025477107614278793,
-0.0296613872051239,
-0.014117313548922539,
-0.032872483134269714,
0.03110393136739731,
-0.014080455526709557,
-0.012544183991849422,
0.014755751937627792,
-0.004774361848831177,
0.015435210429131985,
0.018490968272089958,
-0.007434995844960213,
0.003650625701993704,
-0.011554770171642303,
0.02313104458153248,
-0.008800748735666275,
-0.00025014253333210945,
-0.010713120922446251,
-0.018835019320249557,
-0.006626997143030167,
0.015032641589641571,
-0.01141924224793911,
-0.017447641119360924,
-0.0009867316111922264,
-0.0046593425795435905,
-0.019465964287519455,
-0.019285185262560844,
0.011369258165359497,
-0.024608230218291283,
-0.013479411602020264,
-0.032290101051330566,
-0.010061992332339287,
-0.007962198927998543,
-0.005853301379829645,
0.033416468650102615,
0.019168604165315628,
0.0029112370684742928,
-0.019947754219174385,
-0.0419691801071167,
0.00826924480497837,
-0.010768648236989975,
0.0091254198923707,
-0.010435828007757664,
0.0029590425547212362,
-0.05267452448606491,
-0.009379323571920395,
-0.007721587084233761,
0.015530758537352085,
0.00711978180333972,
-0.007454956416040659,
-0.01714690774679184,
-0.004975354298949242,
-0.003101923270151019,
-0.009462466463446617,
-0.008466819301247597,
-0.00213485024869442,
0.07199717313051224,
-0.003508374560624361,
0.009885059669613838,
-0.036351434886455536,
0.0008482434786856174,
0.006984727457165718,
-0.03319469466805458,
0.0054856035858392715,
-0.038742803037166595,
-0.02046172134578228,
-0.012077734805643559,
-0.006585494615137577,
-0.015739545226097107,
0.01552249863743782,
-0.0024695293977856636,
0.011581824161112309,
-0.016538839787244797,
-0.0009801643900573254,
-0.019788794219493866,
0.021049290895462036,
0.009193351492285728,
0.008474486880004406,
0.014876789413392544,
0.036287251859903336,
0.02023215778172016,
0.006508410442620516,
0.01934545859694481,
0.004524348769336939,
-0.0015161014162003994,
0.02866891771554947,
0.000005526002496480942,
-0.0015779659152030945,
0.008092906326055527,
-0.0072048017755150795,
0.015505845658481121,
0.012636073864996433,
0.005324863828718662,
0.012304304167628288,
-0.022616716101765633,
-0.018545951694250107,
-0.005762305110692978,
0.006561552174389362,
-0.006628589238971472,
0.00792088732123375,
0.025697369128465652,
-0.022877376526594162,
0.019910233095288277,
0.0017267074435949326,
0.007372293621301651,
0.00042696716263890266,
0.024222686886787415,
0.0019967355765402317,
-0.008115018717944622,
-0.006791239604353905,
0.025697030127048492,
0.022656574845314026,
-0.009438920766115189,
0.020991111174225807,
-0.0066474019549787045,
-0.0038035826291888952,
-0.0013565244153141975,
-0.010263161733746529,
0.008085153996944427,
-0.010894098319113255,
0.012961238622665405,
-0.017507296055555344,
0.011215921491384506,
-0.027567613869905472,
0.0014471643371507525,
0.016780512407422066,
0.007237102370709181,
-0.013762423768639565,
0.009447645395994186,
0.00247729429975152,
0.0386337973177433,
0.015991032123565674,
-0.014053714461624622,
0.008547080680727959,
0.016429506242275238,
0.01201131846755743,
-0.016567863523960114,
0.014012839645147324,
-0.0023972252383828163,
0.019596006721258163,
-0.010778797790408134,
-0.00474567199125886,
0.00638936273753643,
-0.003297851886600256,
-0.008864771574735641,
0.014836950227618217,
0.02100754901766777,
0.0031345272436738014,
0.00782744213938713,
-0.002164198085665703,
0.004212104715406895,
0.03336416184902191,
0.0023882482200860977,
0.006215252913534641,
-0.013843370601534843,
-0.000618653604760766,
0.026084469631314278,
-0.01113177090883255,
0.010186232626438141,
0.017258690670132637,
0.005504489876329899,
-0.005506816320121288,
-0.0074829948134720325,
-0.001608390361070633,
-0.022066321223974228,
-0.02317461185157299,
-0.014903660863637924,
0.018603207543492317,
0.006898844614624977,
-0.014222553931176662,
0.014481734484434128,
0.008864117786288261,
-0.002377689117565751,
-0.017420925199985504,
0.03679609298706055,
-0.0139699075371027,
-0.006227119825780392,
0.016739116981625557,
-0.02423062175512314,
0.03290324658155441,
0.01971583627164364,
-0.003166376380249858,
-0.008038058876991272,
-0.009424897842109203,
0.0091252401471138,
-0.005402520298957825,
0.01016298308968544,
0.016672613099217415,
-0.01502637192606926,
-0.019103635102510452,
0.01718853786587715,
-0.0008769955020397902,
-0.02674468792974949,
-0.0006688903085887432,
0.008548900485038757,
0.02494863048195839,
-0.0014292621053755283,
-0.009593081660568714,
-0.0029244860634207726,
-0.014180751517415047,
0.01012369804084301,
-0.016474051401019096,
-0.0009378073737025261,
-0.02738231047987938,
0.0023492230102419853,
-0.0005375342443585396,
0.004778552800416946,
-0.0003121541813015938,
0.0020752863492816687,
-0.0064568836241960526,
0.02791062742471695,
0.021510910242795944,
0.013530977070331573,
0.014469442889094353,
-0.011833555065095425,
0.011387135833501816,
-0.008845414035022259,
0.020679032430052757,
-0.005021248012781143,
0.00019417330622673035,
0.013939660042524338,
-0.012194622308015823,
0.003196949139237404,
0.02494673803448677,
-0.01769471913576126,
-0.038904234766960144,
0.0009615765884518623,
0.017074814066290855,
0.005016535520553589,
-0.0020097875967621803,
-0.035005975514650345,
0.0028772407677024603,
-0.014880010858178139,
-0.007543469779193401,
-0.01633254811167717,
-0.007561472710222006,
-0.0035896513145416975,
-0.0036726314574480057,
-0.017519962042570114,
-0.008595438674092293,
0.00030586228240281343,
-0.01933608017861843,
0.0008187995990738273,
-0.0037479992024600506,
0.006510297767817974,
0.010131247341632843,
-0.010239926166832447,
-0.006406188476830721,
-0.01891086809337139,
-0.006279981695115566,
0.017584223300218582,
-0.0063909790478646755,
-0.0005559269338846207,
0.0013853935524821281,
0.010628338903188705,
-0.002920313971117139,
-0.0028239721432328224,
-0.006700726225972176
] | [
-0.31375858187675476,
0.02515958994626999,
0.6704555749893188,
0.023297443985939026,
0.027392268180847168,
-0.11572956293821335,
0.004720880649983883,
-0.332511842250824,
-0.09338757395744324,
-0.44217029213905334,
-0.136233389377594,
0.30091211199760437,
-0.622600793838501,
0.11165254563093185,
0.09239619970321655,
0.6787546277046204,
-0.032114624977111816,
0.2426847517490387,
-0.06760376691818237,
-1.0437679290771484,
-0.023833753541111946,
0.028418801724910736,
0.6356273889541626,
0.03237063065171242,
0.7314069271087646,
-0.2539735734462738,
0.274045467376709,
-0.7299250960350037,
0.3985382318496704,
-0.18040239810943604,
-0.0841938927769661,
0.49306395649909973,
0.21756936609745026,
0.25533327460289,
-0.12169330567121506,
0.238827645778656,
-0.4099308252334595,
-0.11406233161687851,
0.170804962515831,
0.12033578008413315,
-0.17351219058036804,
-0.46044430136680603,
-0.2292330414056778,
0.25695282220840454,
0.010648435913026333,
-0.15620535612106323,
-1.199575662612915,
0.8099559545516968,
0.3502500653266907,
-0.3414539098739624,
-0.6561930179595947,
0.16268454492092133,
0.47252291440963745,
0.12803345918655396,
0.1360258162021637,
0.24363522231578827,
-0.5652040243148804,
0.10580602288246155,
0.46266475319862366,
-0.8388252258300781,
0.31947603821754456,
0.18832451105117798,
-0.6567409038543701,
0.5087262392044067,
0.2187473028898239,
0.6676241755485535,
-0.10113135725259781,
-0.6964017152786255,
-0.4740335941314697,
-0.5689747333526611,
-0.10279711335897446,
-0.13163134455680847,
-0.1759650856256485,
-0.02636423334479332,
-0.13131475448608398,
-0.045355819165706635,
-0.37477052211761475,
-0.06953636556863785,
-0.01566608063876629,
0.1315440535545349,
-0.2817074656486511,
0.08543717116117477,
-0.03862357139587402,
0.3066471219062805,
0.40226447582244873,
-0.13099448382854462,
-0.2110426276922226,
0.21416515111923218,
-0.362968385219574,
-0.24499249458312988,
-0.4736829698085785,
-0.03928608074784279,
0.10374043136835098,
0.22222930192947388,
0.11358994245529175,
0.4663081765174866,
0.14202265441417694,
-0.2825416922569275,
0.11209337413311005,
0.0565129779279232,
-0.8042872548103333,
0.36873194575309753,
0.4352671205997467,
-0.6195833086967468,
-0.4740491509437561,
-0.3635483682155609,
0.077082559466362,
-0.537474513053894,
-0.3387114703655243,
0.13320386409759521,
-0.3517092764377594,
-0.24496838450431824,
-0.2677553594112396,
-0.3489183783531189,
0.3465418517589569,
0.10441511869430542,
-0.020525330677628517,
-0.4742567837238312,
0.2394115924835205,
0.11663243919610977,
-0.07813281565904617,
1.3818291425704956,
-0.25754737854003906,
0.5165768265724182,
-0.17141760885715485,
-0.13004523515701294,
0.5098742842674255,
-0.24990247189998627,
-0.42324087023735046,
0.14604169130325317,
0.1662934422492981,
1.227700114250183,
-0.37707871198654175,
0.21210238337516785,
-0.0591975636780262,
0.35307496786117554,
0.29699575901031494,
0.21139150857925415,
0.214008167386055,
0.22666136920452118,
-0.06067516654729843,
-0.5497263669967651,
-0.2628384232521057,
-0.28499776124954224,
0.07437938451766968,
-0.28365835547447205,
0.05593731254339218,
-0.40110543370246887,
0.11280202865600586,
-0.3450844883918762,
-0.005094681866466999,
-0.16633684933185577,
-0.6576865315437317,
0.39796045422554016,
-0.3539138436317444,
0.3957677483558655,
0.46227067708969116,
-0.1420714408159256,
0.18450666964054108,
0.285561203956604,
0.08632532507181168,
-0.1407213658094406,
-0.02344640903174877,
-0.04603385925292969,
-0.048683155328035355,
0.07801985740661621,
0.6273695826530457,
0.5995087027549744,
-0.00807507149875164,
-0.684935450553894,
-0.4276253581047058,
-0.35303401947021484,
0.27867063879966736,
-0.47345349192619324,
0.06629833579063416,
-0.24172432720661163,
0.4266689419746399,
-0.12134068459272385,
0.012750271707773209,
-0.18804194033145905,
-0.8005384802818298,
0.0712427869439125,
-0.40553054213523865,
-0.08646298944950104,
0.2127125859260559,
-0.06547298282384872,
0.4196931719779968,
0.1588529348373413,
0.04925297200679779,
0.30535775423049927,
0.2775524854660034,
-0.20978675782680511,
0.3643988072872162,
-0.6130818128585815,
1.2943904399871826,
0.08651726692914963,
-0.08599701523780823,
1.4925284385681152,
0.1395038664340973,
0.2436167150735855,
-0.11871291697025299,
0.18920789659023285,
0.7406266331672668,
-0.6060634255409241,
0.24405981600284576,
-0.07274278998374939,
-0.051912564784288406,
-0.006418091244995594,
0.09367404133081436,
-0.002712213434278965,
-0.07295750081539154,
-0.05982973054051399,
-0.0486825592815876,
-0.11577952653169632,
0.4209234118461609,
-0.5090275406837463,
-0.18218962848186493,
-0.12858301401138306,
-0.3914719521999359,
0.1374049335718155,
0.2257736772298813,
-0.6212827563285828,
0.42044079303741455,
1.1411502361297607,
-0.47578588128089905,
0.8666259050369263,
0.782793402671814,
0.28700578212738037,
0.6470657587051392,
0.018269367516040802,
0.21815542876720428,
-0.6076258420944214,
0.17805761098861694,
-0.292108952999115,
-0.29068833589553833,
0.1851528286933899,
0.3925055265426636,
0.02273823320865631,
-0.4732280373573303,
-0.26852959394454956,
-0.15859325230121613,
0.7844504117965698,
-0.5276258587837219,
-0.10432358086109161,
0.07827901095151901,
-0.35210204124450684,
-0.3034202456474304,
0.09765209257602692,
-0.489816278219223,
-0.01921982690691948,
-0.0717664584517479,
0.19000478088855743,
-0.1719774603843689,
-0.7775766253471375,
0.4105713665485382,
0.08628275245428085,
-0.16893164813518524,
0.1502017378807068,
0.20958048105239868,
-0.5070258975028992,
0.08328505605459213,
-0.37667638063430786,
-0.5134874582290649,
0.24994228780269623,
0.046469796448946,
-0.4473268687725067,
-0.43443939089775085,
-0.01887679100036621,
1.0376193523406982,
0.5545293092727661,
0.0827646479010582,
0.1459980607032776,
-0.48278748989105225,
-0.00741466274484992,
-0.09852099418640137,
-0.31011056900024414,
0.02702147141098976,
0.8244943618774414,
0.06294503062963486,
-0.2408994734287262,
-0.04123212769627571,
0.16715273261070251,
0.6685044169425964,
-0.10042496770620346,
-0.7362276315689087,
0.1096540242433548,
-0.36487868428230286,
-0.3841128349304199,
-0.3245272934436798,
-0.38131704926490784,
-0.5399125218391418,
0.04510055109858513,
-0.3225418031215668,
-0.019550060853362083,
0.05124892666935921,
0.21063704788684845,
-0.3169618844985962,
0.526086688041687,
0.3695456385612488,
-0.044639572501182556,
-0.587816059589386,
0.09810929745435715,
-0.38892582058906555,
-0.03045879863202572,
-0.10912656784057617,
0.20977267622947693,
-0.8016044497489929,
0.26829203963279724,
-5.926266193389893,
-0.005457504652440548,
0.08205921202898026,
-0.2987626791000366,
0.02806941606104374,
-0.16434650123119354,
0.42718082666397095,
0.2169160097837448,
0.7303586006164551,
0.22509336471557617,
0.3007919490337372,
0.3266291916370392,
-0.368204265832901,
-0.07712828367948532,
-0.19252446293830872,
0.006141980178654194,
0.19443731009960175,
-0.07304951548576355,
0.614604651927948,
-0.028335973620414734,
0.16277222335338593,
-0.09823481738567352,
0.06990372389554977,
0.17464816570281982,
0.08668786287307739,
-0.050111547112464905,
-0.7291851043701172,
-0.06160175800323486,
0.11166056245565414,
-0.8311387896537781,
-0.15884914994239807,
-0.3842759132385254,
0.2181301712989807,
0.11355980485677719,
0.6184064745903015,
-0.06364020705223083,
0.18879763782024384,
0.1931806057691574,
-0.006867401767522097,
-0.530670702457428,
0.6982448697090149,
0.1293087750673294,
-0.46601203083992004,
-0.1806543618440628,
-0.07567687332630157,
-0.05591154843568802,
-0.43818220496177673,
0.44757235050201416,
-0.2773369252681732,
0.741918683052063,
-0.4125504493713379,
-0.3189801871776581,
0.04290986806154251,
0.22156864404678345,
0.8290901780128479,
0.17064917087554932,
-0.3280608654022217,
-0.24312415719032288,
-0.26737645268440247,
-0.3767189383506775,
-0.27226582169532776,
-0.3157873749732971,
-0.6885207891464233,
-0.5208406448364258,
-0.15085484087467194,
0.4195980429649353,
-0.896679162979126,
-0.348904550075531,
0.7263937592506409,
0.024967342615127563,
0.03736171871423721,
0.219937264919281,
0.20816747844219208,
-0.39917996525764465,
0.13882748782634735,
-0.24832704663276672,
0.1845582127571106,
0.11480887979269028,
-0.12213829904794693,
-0.2359284609556198,
-0.4034181535243988,
0.4738047122955322,
-0.0811084434390068,
-0.2664317190647125,
0.23455332219600677,
0.11348790675401688,
0.178545743227005,
0.01053588092327118,
-0.13720658421516418,
0.5966164469718933,
0.5696277022361755,
-0.34173744916915894,
-0.004448244348168373,
0.6591191291809082,
0.28362125158309937,
0.03372610732913017,
0.46478575468063354,
0.36410534381866455,
0.3700006306171417,
-0.22713634371757507,
1.1136757135391235,
-0.09290462732315063,
-0.2666970491409302,
-0.6282936930656433,
-0.07030472159385681,
0.8586141467094421,
-0.6953439116477966,
0.0895540788769722,
0.7933898568153381,
-0.3349952697753906,
-0.15536771714687347,
-0.01631568931043148,
-0.1583074927330017,
-0.23388120532035828,
0.32063907384872437,
-0.09302853792905807,
0.03137621283531189,
-0.018126729875802994,
0.5831947922706604,
-0.13872826099395752,
0.08211921900510788,
0.3216715157032013,
-0.8860765695571899,
0.5609320402145386,
0.20164859294891357,
0.2517300248146057,
0.01990879327058792,
0.6441804766654968,
-0.5571244955062866,
-0.11060802638530731,
0.5936742424964905,
-0.20745131373405457,
-0.20276162028312683,
0.171722412109375,
0.48151886463165283,
-0.3692333996295929,
-0.25471746921539307,
0.5889801383018494,
0.46574071049690247,
0.06130417436361313,
0.24651479721069336,
-0.08035047352313995,
-0.2727048397064209,
-0.1412545144557953,
0.18342159688472748,
0.2427612990140915,
-0.03204427286982536,
0.2362975925207138,
-0.39774125814437866,
-0.16003182530403137,
0.11132387071847916,
-0.2651926279067993,
-0.13688120245933533,
-0.05906471982598305,
-0.038954444229602814,
0.08941792696714401,
0.2738548815250397,
0.09916489571332932,
0.24242204427719116,
-0.4569464921951294,
0.15748246014118195,
0.3603607416152954,
-0.045860644429922104,
0.2011529505252838,
-0.40336620807647705,
-0.1457979530096054,
-0.21672111749649048,
-0.665763795375824,
-0.213658407330513,
0.5430479049682617,
-0.42409852147102356,
-0.06865879148244858,
-0.012419802136719227,
-0.30229324102401733,
0.22072508931159973,
-0.40623077750205994,
-0.306635320186615,
-0.034040842205286026,
0.04501599073410034,
0.0692039206624031,
-0.13759177923202515,
-0.19817249476909637,
-0.4261772334575653,
0.10041449964046478,
0.02350800484418869,
-0.13754284381866455,
0.380789190530777,
-0.23495011031627655,
0.1193109005689621,
-0.26884302496910095,
0.08227937668561935,
0.0841161236166954,
0.2340143322944641,
-0.4421693980693817,
0.430957555770874,
-0.03774119168519974,
0.1514224261045456,
0.6234581470489502,
-0.06060565263032913,
-0.7765845656394958,
0.37741172313690186,
0.27882111072540283,
-0.3933284282684326,
0.4898648262023926,
0.13037382066249847,
0.3591649830341339,
-0.497361421585083,
0.1513771265745163,
0.11764790117740631,
-0.0701659694314003,
-0.19947406649589539,
-0.44332996010780334,
0.2372128963470459,
0.5095376968383789,
0.19249992072582245,
0.10096960514783859,
0.2464420348405838,
-0.5183849334716797,
-0.41371479630470276,
0.36168617010116577,
0.056145280599594116,
-0.15659649670124054,
0.10100769251585007,
0.24706053733825684,
-0.07303979992866516,
0.2568492591381073,
0.317249596118927,
-1.0902801752090454,
0.35460519790649414,
0.10566908866167068,
0.22467154264450073,
-0.15157820284366608,
0.3216779828071594,
-0.11081326007843018,
-0.08610554039478302,
-0.6342669129371643,
-0.3363516926765442,
0.08689510077238083,
-0.12461185455322266,
0.5380760431289673,
0.5316888093948364,
0.8543538451194763,
-0.5821713209152222,
-0.07898179441690445,
-0.301471471786499,
0.49715912342071533,
0.03530696779489517,
-0.2972785532474518,
-0.29019105434417725,
0.025735123082995415,
0.5828122496604919,
-0.3626910448074341,
0.2773904502391815,
0.33503565192222595,
0.9343845248222351,
0.011846018955111504,
0.002517682733014226,
-0.030484149232506752,
-0.1764165610074997,
0.161918044090271,
-0.1417943239212036,
-0.26749831438064575,
0.1896781623363495,
-0.18938423693180084,
0.08885521441698074,
0.6209547519683838,
-0.35338932275772095,
-0.82792729139328,
0.2529591917991638,
0.08844724297523499,
0.06157020479440689,
-0.10387064516544342,
0.6768574714660645,
0.11019404977560043,
-0.23950731754302979,
0.2221808135509491,
-0.22435569763183594,
0.588189959526062,
0.16117943823337555,
0.21241068840026855,
-0.3372401297092438,
-0.4209931790828705,
0.2435753047466278,
-0.7517927885055542,
0.3900975286960602,
-0.7969495058059692,
0.012648745439946651,
-0.4039739668369293,
0.2839262783527374,
-0.04860366880893707,
-0.327332079410553,
0.13952647149562836,
-0.552356481552124,
-0.04109645634889603,
0.005527104716747999,
-0.11577613651752472,
0.2989181876182556,
0.46341079473495483,
-0.4237791895866394,
0.15616904199123383,
-0.647402286529541,
0.07611002027988434,
0.24299854040145874,
-0.4668159484863281,
-0.19993169605731964,
0.4873068034648895,
0.32203224301338196,
0.03736315295100212,
-0.7780122756958008,
-0.4256080985069275,
-0.2991180419921875,
-0.19265025854110718,
0.5380867719650269,
-0.23037365078926086,
-0.28587013483047485,
0.21425257623195648,
-0.2458706945180893,
-0.09661630541086197,
0.029689813032746315,
0.2284199595451355,
0.3349200189113617,
0.8130173683166504,
-0.07828536629676819,
-0.28747043013572693,
-0.22024963796138763,
0.3985855281352997,
0.31673792004585266,
0.23794224858283997,
-0.06473458558320999,
0.39950087666511536,
0.4831832945346832,
-0.058826085180044174,
-0.12162987142801285,
0.607008159160614,
0.48278895020484924,
0.10004337131977081,
0.3682301938533783,
-0.5400980114936829,
-0.21753497421741486,
-0.18970631062984467,
0.8544397950172424,
0.6778454184532166,
-0.30933427810668945,
-0.26522475481033325,
0.45650118589401245,
-0.14958900213241577,
0.5357962250709534,
0.07024671137332916,
-0.29914528131484985,
0.17881609499454498,
0.5028773546218872,
-0.6991219520568848,
-0.5029780268669128,
0.43909144401550293,
-0.45090368390083313,
-0.2674628496170044,
0.5697837471961975,
-0.21975702047348022,
-0.1573464572429657,
0.04264553636312485,
-0.3123023509979248,
-0.003452629316598177,
-0.03883771225810051,
0.5264544486999512,
0.20019973814487457,
-0.08449773490428925,
0.5521323084831238,
0.037931304425001144,
0.13909576833248138,
-0.4038378894329071,
-0.11648859828710556,
0.1850060522556305,
0.019123295322060585,
-0.04633635655045509,
0.2948334217071533,
-0.5769482851028442,
0.02453850768506527,
-0.07254169136285782,
-0.2706063985824585,
0.34529536962509155,
-0.23461498320102692,
0.375137060880661,
0.1536288559436798,
-0.9738631844520569,
-0.3779990077018738,
-0.41876301169395447,
-0.12829087674617767,
-0.7200119495391846,
-0.0109972869977355,
-0.17264577746391296,
0.2046470046043396,
-0.6318110227584839,
-0.13142016530036926,
-0.3601149320602417,
-0.1758865863084793,
0.06530775129795074,
-0.33468908071517944,
0.2873501777648926,
0.32430633902549744,
0.6170743703842163,
0.25286686420440674,
0.2689173221588135,
0.09485961496829987,
0.30756884813308716,
-0.40704187750816345,
0.1827276647090912,
-0.6536141633987427,
-0.44291865825653076,
0.009681391529738903,
-0.11635500192642212,
1.0671840906143188,
0.8401933312416077,
-0.4139622151851654,
0.33991581201553345,
0.17595669627189636,
0.6226508617401123,
0.7311899065971375,
-0.8393036723136902,
0.36863139271736145,
-0.087639220058918,
-0.3770699203014374,
-0.0867237001657486,
0.6538354754447937,
0.5339733958244324,
-0.4197074770927429,
-0.23969973623752594,
0.49551618099212646,
0.492013156414032,
-0.10045251995325089,
0.28741946816444397,
-0.25837817788124084,
-0.43251410126686096,
-0.5985949635505676,
0.4327394962310791,
-0.31494948267936707,
-0.29381248354911804,
-0.703005850315094,
-0.09959735721349716,
0.47871649265289307,
-0.18706628680229187,
0.31194421648979187,
-0.015471627935767174,
-0.07293329387903214,
0.2974010705947876,
-0.2304966002702713,
-0.10572321712970734,
-0.10279940068721771,
-0.9750210642814636,
-0.39686718583106995,
0.3705270290374756,
0.025085153058171272,
-0.4737854599952698,
-0.24742737412452698,
0.35736942291259766,
0.04023151844739914,
-0.18966659903526306,
-0.03246971592307091,
-0.3316490948200226,
-0.0549822673201561,
-0.03950223699212074
] |
Autophagy is a ubiquitous catabolic process by which damaged or harmful intracellular components are delivered to the lysosomes for self-digestion and recycling. It is critical in cancer treatment. Therapy-induced autophagy predominantly acts as a pro-survival mechanism, but progressive autophagy can lead to non-apoptotic cell death, also known as autophagic cell death. Plants or herbs contain various natural compounds that are widely used in the treatment of many types of malignancies. Emerging evidence indicates that phytochemicals targeting the autophagic pathway are promising agents for cancer treatment. However, these compounds play different roles in autophagy. In this review, we discussed the role of autophagy in cancer development and therapy, and focussed on elucidating the anti-cancer activities of autophagic modulators, especially phytochemicals. Notably, we described a novel premise that the dynamic role of phytochemicals should be evaluated in regulation of autophagy in cancer. | [
-0.013117153197526932,
0.016270261257886887,
0.004664406180381775,
0.016071707010269165,
-0.011139952577650547,
-0.04859199747443199,
0.010621216148138046,
0.014439034275710583,
-0.017924921587109566,
-0.017331194132566452,
-0.03641008213162422,
0.00527117308229208,
-0.009948762133717537,
0.031558215618133545,
0.009805739857256413,
0.03439251333475113,
-0.01929478347301483,
-0.0071830665692687035,
0.010978596284985542,
0.013844425790011883,
0.004552268423140049,
-0.028903912752866745,
0.010976136662065983,
-0.030761271715164185,
0.0100868484005332,
0.019750608131289482,
0.0005743918591178954,
-0.003508131019771099,
0.009969481267035007,
0.026591867208480835,
-0.03479046747088432,
0.017547760158777237,
0.010918578132987022,
-0.031016923487186432,
0.017598401755094528,
-0.004520164802670479,
0.00019142881501466036,
0.01280687004327774,
0.01279232557862997,
-0.00400770828127861,
0.021619604900479317,
-0.00617756275460124,
0.006263751070946455,
-0.0007058666087687016,
-0.012872794643044472,
-0.000547521747648716,
0.003856286872178316,
0.013248094357550144,
-0.016133567318320274,
0.01131785474717617,
-0.006005778908729553,
-0.009830227121710777,
-0.0014246180653572083,
-0.024031057953834534,
-0.00695969769731164,
0.0016572137828916311,
0.0206315778195858,
-0.009180866181850433,
-0.011409835889935493,
-0.03164665028452873,
-0.0010852540144696832,
-0.011763107031583786,
0.0017003822140395641,
0.02397233247756958,
-0.029478808864951134,
-0.06679626554250717,
-0.0007966053672134876,
0.012241857126355171,
0.0026330002583563328,
-0.009194862097501755,
-0.013973026536405087,
0.008729705587029457,
0.018444646149873734,
-0.006172774359583855,
0.013325492851436138,
-0.003136733779683709,
-0.0006299098022282124,
0.010871239937841892,
0.03132668510079384,
0.011698208749294281,
-0.01622987724840641,
-0.030255833640694618,
-0.003389960154891014,
0.017579559236764908,
-0.019015144556760788,
0.016418298706412315,
0.0011430250015109777,
-0.01622682437300682,
0.018022269010543823,
-0.005746465642005205,
0.006480839103460312,
-0.0004469198174774647,
-0.007594094146043062,
0.015886787325143814,
0.0028973538428545,
-0.007985560223460197,
-0.013718733564019203,
-0.00009480537846684456,
0.01098771020770073,
0.0012626214884221554,
-0.007833854295313358,
0.014447811990976334,
0.01277089025825262,
-0.005116090644150972,
-0.014781246893107891,
0.009050484746694565,
-0.010455861687660217,
-0.018479499965906143,
0.041231073439121246,
0.00927249900996685,
0.005197529681026936,
-0.010456813499331474,
-0.009602073580026627,
0.006321561988443136,
0.003717568702995777,
-0.007014411501586437,
0.016132758930325508,
-0.018648650497198105,
0.015334898605942726,
-0.011154593899846077,
0.012450123205780983,
-0.0019245860166847706,
0.013856986537575722,
-0.010009506717324257,
0.0035930455196648836,
-0.007337478455156088,
0.02652907930314541,
-0.024584006518125534,
-0.0008364296518266201,
-0.01356098148971796,
-0.009585186839103699,
-0.0042225951328873634,
0.04522886499762535,
0.0130205312743783,
0.009901771321892738,
-0.004826984368264675,
-0.0026977150700986385,
-0.019503477960824966,
0.011258615180850029,
-0.01894218474626541,
-0.004102503880858421,
0.0020954557694494724,
0.0006153793074190617,
0.015701649710536003,
0.0276293084025383,
0.006758004892617464,
-0.028307007625699043,
0.0032516843639314175,
0.005480417050421238,
-0.004729851149022579,
-0.025934841483831406,
0.004667205736041069,
0.011411603540182114,
0.0007982947863638401,
0.02115303836762905,
-0.014611603692173958,
0.008241750299930573,
-0.004094050731509924,
-0.011256452649831772,
-0.02064797654747963,
-0.021538376808166504,
-0.028639379888772964,
0.02402496337890625,
0.008321010507643223,
0.006046785041689873,
-0.0123518081381917,
0.0075081405229866505,
-0.008377943187952042,
0.0084389578551054,
0.0034407167695462704,
-0.014608446508646011,
0.023359591141343117,
-0.024997403845191002,
0.014541883952915668,
0.013195166364312172,
0.00484068226069212,
-0.006006826646625996,
0.0082838274538517,
-0.00015064675244502723,
0.06616020202636719,
0.02779485285282135,
0.017091628164052963,
0.0027381381951272488,
0.02072998136281967,
0.01521309558302164,
0.001279653748497367,
0.009905671700835228,
-0.007760226726531982,
0.0010733830276876688,
-0.006842547561973333,
-0.028593173250555992,
0.03229954093694687,
-0.006504440680146217,
0.008721906691789627,
0.012909503653645515,
0.004408424254506826,
-0.018959855660796165,
0.006768867373466492,
0.015426907688379288,
0.006695591378957033,
-0.00706889946013689,
-0.016111189499497414,
0.0262578334659338,
-0.02711905725300312,
-0.009722642600536346,
-0.028250444680452347,
-0.023964716121554375,
-0.013001677580177784,
0.03371267765760422,
0.00880191009491682,
0.02562175877392292,
0.0012430623173713684,
-0.006155919749289751,
-0.013788165524601936,
-0.01704532466828823,
-0.010470153763890266,
-0.008829712867736816,
0.023093193769454956,
-0.02296937257051468,
-0.010908082127571106,
-0.005213615018874407,
0.010070763528347015,
0.029079552739858627,
0.0031068483367562294,
-0.010998395271599293,
0.0045949299819767475,
0.000006215181201696396,
0.015584290027618408,
0.0017994977533817291,
-0.00253473361954093,
0.0010171947069466114,
0.004576821345835924,
-0.008231538347899914,
-0.0033394619822502136,
0.01773262396454811,
0.002362027997151017,
0.010426249355077744,
-0.017573656514286995,
0.02257406711578369,
-0.01712759956717491,
0.02225155010819435,
0.020538512617349625,
-0.009426906704902649,
-0.0008724050130695105,
0.006019954103976488,
0.0030465908348560333,
-0.00035206880420446396,
0.008429278619587421,
-0.005618692841380835,
-0.017143690958619118,
0.006624868139624596,
-0.010525347664952278,
-0.006967838387936354,
-0.0010572681203484535,
0.013813795521855354,
-0.02208295464515686,
0.0075667621567845345,
-0.022875182330608368,
0.02760038524866104,
-0.009759990498423576,
0.0014922174159437418,
0.006451940163969994,
0.0007856180891394615,
-0.02945077046751976,
-0.012499812059104443,
0.016186043620109558,
0.027302753180265427,
-0.02890694886445999,
0.012430398724973202,
0.005259431898593903,
0.005760153755545616,
-0.0072924853302538395,
0.0070443060249090195,
-0.08152545243501663,
-0.014157422818243504,
-0.01107519306242466,
0.0045721749775111675,
0.011683713644742966,
0.0017010308802127838,
0.01466657966375351,
0.010996675118803978,
-0.01114596240222454,
-0.022827470675110817,
0.007115917280316353,
0.029529225081205368,
-0.0014081781264394522,
-0.041985902935266495,
0.003961671143770218,
-0.0013935959432274103,
0.015450019389390945,
0.026616912335157394,
0.0007844849023967981,
-0.012871559709310532,
0.005956772714853287,
-0.013535436242818832,
0.018179111182689667,
-0.015022257342934608,
0.014744002372026443,
0.017259448766708374,
0.02900068834424019,
0.015551846474409103,
-0.01502925343811512,
0.010448659770190716,
0.029401937499642372,
0.003965201787650585,
-0.019882913678884506,
0.004050760995596647,
0.015536369755864143,
0.02308056689798832,
-0.010180367156863213,
-0.01006280817091465,
-0.019747313112020493,
0.02555776573717594,
0.0021373527124524117,
-0.006707374006509781,
-0.0002160758012905717,
-0.011715966276824474,
0.029799360781908035,
0.025387395173311234,
-0.030701082199811935,
-0.0056784930638968945,
0.010029751807451248,
0.0006901203887537122,
0.000983931589871645,
0.013811051845550537,
0.0007716831751167774,
0.020719531923532486,
-0.011591720394790173,
0.008692563511431217,
-0.010230720043182373,
-0.0038002654910087585,
-0.013894711621105671,
0.0006009942153468728,
-0.0042702932842075825,
-0.01803591102361679,
-0.015349498949944973,
0.011684705503284931,
-0.00923609733581543,
0.004109496716409922,
0.01876119337975979,
0.012306181713938713,
0.001834540395066142,
0.0024913682136684656,
0.01555282436311245,
0.00669458881020546,
-0.005036340095102787,
-0.009994088672101498,
0.014707650057971478,
-0.0087876096367836,
-0.014330740086734295,
-0.013178667053580284,
-0.0009025768376886845,
0.010332003235816956,
-0.018006345257163048,
0.010413971729576588,
-0.010938724502921104,
0.008745028637349606,
-0.008387146517634392,
-0.02009744383394718,
-0.0006732707843184471,
0.028323929756879807,
0.0023747426457703114,
-0.016947850584983826,
-0.012631447985768318,
0.020169977098703384,
-0.0303349606692791,
0.007978010922670364,
0.011097810231149197,
-0.030634688213467598,
0.014484265819191933,
0.012641364708542824,
0.0093348678201437,
0.010534439235925674,
-0.0249013788998127,
-0.0028064644429832697,
-0.024098046123981476,
-0.01659296452999115,
-0.027789218351244926,
0.015833809971809387,
0.016188539564609528,
0.02592804655432701,
0.005313916131854057,
-0.0015195657033473253,
0.011867238208651543,
0.004929007962346077,
-0.016378194093704224,
0.03196406364440918,
0.008971795439720154,
-0.0037552332505583763,
0.004131991416215897,
-0.020720655098557472,
0.07165223360061646,
0.012460854835808277,
0.003374398685991764,
-0.012163415551185608,
-0.0009097266010940075,
-0.023892737925052643,
-0.04483778029680252,
0.019918881356716156,
0.021096404641866684,
-0.029371198266744614,
0.014932720921933651,
0.0017751781269907951,
0.017156600952148438,
0.005029767751693726,
-0.0031583020463585854,
0.010205836966633797,
-0.01383576076477766,
-0.028170442208647728,
-0.004552537575364113,
-0.026003394275903702,
-0.0009308392181992531,
0.005211121402680874,
-0.0028722684364765882,
0.017018459737300873,
0.016320329159498215,
-0.010609833523631096,
-0.020800814032554626,
-0.01287846453487873,
-0.005665848962962627,
0.01163530070334673,
-0.025426017120480537,
-0.0003727828152477741,
-0.003587051760405302,
0.01880887895822525,
0.023982767015695572,
0.026540175080299377,
0.008588133379817009,
-0.008025881834328175,
0.007678789086639881,
-0.00008915667422115803,
-0.006127661559730768,
-0.011381732299923897,
0.015771113336086273,
0.014628622680902481,
-0.011322632431983948,
-0.0015733616892248392,
0.014525655657052994,
-0.006135742180049419,
-0.01331866905093193,
-0.001959306187927723,
-0.006782968528568745,
-0.012646079063415527,
0.005441808141767979,
-0.011490266770124435,
-0.00951358862221241,
-0.02529529109597206,
0.021270278841257095,
-0.016658689826726913,
-0.02825603075325489,
-0.00937691330909729,
-0.013176931999623775,
-0.00009040255099534988,
0.04296577349305153,
0.010488186031579971,
0.010160377249121666,
-0.014761490747332573,
0.03195970505475998,
-0.005846657790243626,
0.028440065681934357,
-0.030255895107984543,
0.014852702617645264,
-0.00016450020484626293,
-0.028766382485628128,
-0.01324748806655407,
-0.003644695272669196,
0.005055444315075874,
0.005725379101932049,
-0.017534252256155014,
0.036842793226242065,
-0.006891446188092232,
0.004540566820651293,
0.016226215288043022,
-0.005886606872081757,
-0.010957937687635422,
0.019581874832510948,
-0.008890800178050995,
0.02453799918293953,
-0.0747249573469162,
-0.018791642040014267,
-0.0016298387199640274,
-0.0036983154714107513,
-0.012839419767260551,
0.014115942642092705,
-0.003549540415406227,
-0.016965312883257866,
0.022819001227617264,
0.00009557622252032161,
-0.013978691771626472,
0.010894358158111572,
-0.020960327237844467,
0.013444924727082253,
0.011427045799791813,
-0.01501799188554287,
-0.007695405278354883,
-0.00547496322542429,
-0.02723175287246704,
-0.00015864218585193157,
0.015039087273180485,
-0.01666748896241188,
0.0024652741849422455,
0.018170617520809174,
-0.011089296080172062,
-0.08039484173059464,
0.01777494326233864,
-0.005417664535343647,
-0.02768239751458168,
0.015023106709122658,
-0.01950671151280403,
-0.004723610356450081,
-0.01814829185605049,
0.01325448602437973,
-0.015051396563649178,
-0.014430631883442402,
-0.003224367741495371,
-0.004884093068540096,
-0.0008731380803510547,
-0.0007852488197386265,
-0.005460605025291443,
0.013316426426172256,
-0.019082939252257347,
-0.017254699021577835,
-0.025651320815086365,
-0.006395245436578989,
0.025414593517780304,
-0.009814046323299408,
-0.004947517067193985,
-0.013639518991112709,
-0.021642236039042473,
0.005221587605774403,
0.010426069609820843,
-0.019845470786094666,
0.007819725200533867,
0.00019979069475084543,
0.010120734572410583,
-0.016698895022273064,
-0.05106925219297409,
0.003731553442776203,
-0.012620777823030949,
-0.015000954270362854,
0.008160325698554516,
0.003670952981337905,
-0.007358808536082506,
-0.007575361989438534,
0.004176191054284573,
-0.004565500654280186,
-0.004041967447847128,
0.009663466364145279,
0.004647077992558479,
0.004618133418262005,
-0.0009486397611908615,
0.009412858635187149,
0.006853211671113968,
0.0069435336627066135,
-0.030219988897442818,
0.0024919200222939253,
-0.00960625521838665,
-0.032313182950019836,
0.018686894327402115,
-0.008429547771811485,
0.01115334965288639,
-0.0036048428155481815,
0.017058296129107475,
-0.00165840913541615,
-0.013138634152710438,
-0.0008630970260128379,
0.07083538174629211,
0.017569322139024734,
-0.0038716073613613844,
-0.01724540814757347,
-0.005510123446583748,
0.003500283695757389,
-0.001537282019853592,
-0.0009196142200380564,
-0.013306223787367344,
-0.008401088416576385,
0.033565960824489594,
-0.0061378455720841885,
-0.0021812254562973976,
0.006526308599859476,
-0.006381739396601915,
0.0006473725661635399,
-0.028490550816059113,
0.010829519480466843,
0.029326388612389565,
-0.007084795273840427,
-0.011020652949810028,
-0.012055009603500366,
-0.03147563338279724,
0.01257857121527195,
0.028769319877028465,
-0.006136529613286257,
-0.015526581555604935,
0.01881171017885208,
-0.01694083958864212,
-0.016409095376729965,
-0.014637244865298271,
0.002861269749701023,
-0.0037572369910776615,
-0.006813105661422014,
0.026455361396074295,
0.010115781798958778,
-0.008148061111569405,
-0.0022426829673349857,
-0.005881429184228182,
-0.0013814147096127272,
0.007955354638397694,
0.006913585122674704,
0.0018885622266680002,
0.0023095153737813234,
0.004829996265470982,
-0.012145521119236946,
-0.006855413783341646,
0.007905689999461174,
-0.0006728742737323046,
0.018576819449663162,
-0.004164930898696184,
0.006023390684276819,
-0.02295699715614319,
0.012202708050608635,
-0.01813540607690811,
-0.008386749774217606,
-0.019738569855690002,
0.008484249003231525,
-0.0300772562623024,
-0.02432873100042343,
0.0295034758746624,
-0.03142233192920685,
-0.028146831318736076,
-0.01720067672431469,
0.019389674067497253,
0.016450919210910797,
0.023008346557617188,
-0.00896258745342493,
-0.008870302699506283,
0.014062040485441685,
0.011846113950014114,
-0.008316396735608578,
0.0015179953770712018,
0.010885950177907944,
0.002719656564295292,
-0.0052608298137784,
0.003533869981765747,
-0.004679717123508453,
-0.0017560306005179882,
0.0007381319301202893,
-0.01103326864540577,
0.010189601220190525,
0.023577872663736343,
-0.006142590194940567,
-0.03575115278363228,
-0.012204911559820175,
-0.006990039721131325,
0.00985508132725954,
-0.007328104693442583,
0.008631995879113674,
0.0026476290076971054,
-0.010964775457978249,
0.0020148889161646366,
-0.02240351401269436,
0.00856691412627697,
0.03652529790997505,
-0.023797132074832916,
0.008286755532026291,
0.001570410095155239,
0.02659735269844532,
-0.03132646530866623,
0.006291570607572794,
0.0014132214710116386,
-0.004595469683408737,
-0.022905414924025536,
-0.01257079467177391,
0.00946225505322218,
-0.001323118805885315,
-0.007143871858716011,
-0.015974584966897964,
0.022383343428373337,
0.01997743919491768,
0.02119474858045578,
0.021517783403396606,
0.0009114426793530583,
0.0031032878905534744,
-0.011366507969796658,
0.02125019207596779,
0.014980395324528217,
-0.013325134292244911,
-0.01971975341439247,
-0.020541422069072723,
-0.023898128420114517,
0.012749834917485714,
0.008573820814490318,
-0.01292871218174696,
-0.0030125996563583612,
-0.002550979843363166,
0.005117103457450867,
-0.005137277767062187,
0.015771908685564995,
-0.025225631892681122,
0.01010624784976244,
-0.0035917824134230614,
-0.01143631525337696,
0.009657004848122597,
-0.014697007834911346,
0.02343526855111122,
-0.021404100582003593,
0.0287461057305336,
0.016410687938332558,
0.009672541171312332,
-0.005456574726849794,
0.0037393132224678993,
0.010079349391162395,
-0.0034288507886230946,
0.031718660145998,
-0.0024865809828042984,
0.0172838494181633,
-0.008420858532190323,
0.017774730920791626,
0.015045959502458572,
0.0046697743237018585,
-0.004316307604312897,
0.0010274187661707401,
0.03322182595729828,
0.015020293183624744,
0.03455166891217232,
-0.0029841626528650522,
0.010656213387846947,
-0.011525627225637436,
-0.035805683583021164,
-0.016625192016363144,
0.00888194888830185,
0.014294458553195,
0.026103127747774124,
-0.019921977072954178,
0.022173762321472168,
0.012996514327824116,
-0.010498778894543648,
0.004549807403236628,
-0.015073036774992943,
0.00697009451687336,
-0.008856973610818386,
-0.02164953202009201,
-0.009710386395454407,
-0.005508352071046829,
-0.028015710413455963,
0.002367249224334955,
-0.0073685422539711,
-0.009241309948265553,
-0.021630683913826942,
-0.0018049711361527443,
-0.006850350182503462,
0.006744172424077988,
-0.010664878413081169,
-0.005543346982449293,
-0.005709982942789793,
-0.006498995237052441,
-0.010706727392971516,
-0.021027369424700737,
0.001824384555220604,
0.009467875584959984,
-0.0013821115717291832,
-0.005921574309468269,
-0.014904110692441463,
-0.008410942740738392,
-0.03909202292561531,
0.013917072676122189,
0.013475446961820126,
-0.002577335573732853,
-0.01741734892129898
] | [
0.4462418854236603,
0.3245066702365875,
-0.16353924572467804,
-0.06738024950027466,
0.38198915123939514,
-0.012580440379679203,
0.19479362666606903,
0.4572651982307434,
0.2185298651456833,
-0.4644503891468048,
-0.12216285616159439,
0.3902720808982849,
-0.755646288394928,
0.20015816390514374,
-0.32630249857902527,
0.4126599431037903,
0.49795258045196533,
0.5161498785018921,
-0.43096521496772766,
0.04944871366024017,
-0.5252045392990112,
-0.17606677114963531,
0.5168234705924988,
0.2568418085575104,
0.2517033517360687,
-0.27916279435157776,
0.13822096586227417,
-0.12599556148052216,
-0.372973769903183,
-0.1481262445449829,
-0.02556261047720909,
0.0985715463757515,
0.4690423309803009,
-0.4320768415927887,
0.02892804704606533,
0.0960390716791153,
-0.597815990447998,
-0.5125327706336975,
-0.44897186756134033,
0.06165694072842598,
-0.45714396238327026,
0.25059252977371216,
-0.08716148138046265,
0.1400940865278244,
-0.025859758257865906,
-0.12506984174251556,
-1.4500881433486938,
0.9677571058273315,
-0.4200694262981415,
0.152593731880188,
-0.0066707623191177845,
-0.2042108178138733,
0.4072646200656891,
0.498293936252594,
0.270102858543396,
0.505939245223999,
-0.44608286023139954,
-0.1872122585773468,
0.05666514113545418,
-0.48990491032600403,
0.01886438950896263,
-0.01749264821410179,
-0.39904478192329407,
0.5145426392555237,
0.30651384592056274,
0.13532185554504395,
-0.3941270411014557,
-0.11041057109832764,
-0.5534285306930542,
-0.3758894205093384,
-0.22906050086021423,
-0.5298098921775818,
-0.09048114717006683,
0.5262501239776611,
-0.2837252914905548,
-0.6393130421638489,
-0.13502497971057892,
-0.47573938965797424,
0.05389251932501793,
-0.0900154784321785,
-0.21499375998973846,
0.5560911297798157,
-0.24642975628376007,
0.2811427116394043,
0.5320862531661987,
-0.24588246643543243,
-0.2609045207500458,
1.3122066259384155,
-0.23138083517551422,
-0.48379433155059814,
0.4825444221496582,
0.14755627512931824,
0.38970670104026794,
0.044730547815561295,
0.1619931012392044,
0.22502107918262482,
0.23285704851150513,
-0.3036154806613922,
-0.2013162523508072,
0.05313071236014366,
0.12802769243717194,
0.19170574843883514,
-0.1798768937587738,
-0.35627272725105286,
-0.07659844309091568,
-0.08373840153217316,
0.15178807079792023,
-0.26375532150268555,
0.3113177418708801,
-0.0134196188300848,
-0.7342317700386047,
0.20935490727424622,
-0.6789960265159607,
-0.15664058923721313,
-0.46518635749816895,
0.329271137714386,
-0.18607279658317566,
0.059742413461208344,
0.061052508652210236,
-0.12961207330226898,
0.06294295191764832,
0.8000573515892029,
-0.23635314404964447,
0.1579674929380417,
-0.47429412603378296,
-0.32483381032943726,
-0.178897425532341,
0.1075848788022995,
-0.660784900188446,
0.17929768562316895,
0.5024299621582031,
0.571184515953064,
-0.5340030789375305,
-0.11595712602138519,
0.1614280492067337,
-0.0018689825665205717,
0.3554081618785858,
0.1179620623588562,
1.1711000204086304,
-0.12552949786186218,
-0.46265938878059387,
-0.6881829500198364,
0.0018601944902911782,
-0.011938381940126419,
-0.22396276891231537,
-0.44503360986709595,
0.14043720066547394,
-0.1643601953983307,
-0.07911984622478485,
-0.23656493425369263,
0.3050817847251892,
-0.25644823908805847,
-0.647989809513092,
0.06718600541353226,
-0.09707286953926086,
0.4550155699253082,
-0.0740685909986496,
-0.6744695901870728,
-0.19868305325508118,
0.07198768854141235,
0.29305994510650635,
-0.15685328841209412,
-0.3851061761379242,
-0.4746742248535156,
0.3698035180568695,
-0.2925181984901428,
0.35796016454696655,
0.7964465022087097,
0.29674115777015686,
-0.5972415804862976,
-0.605268657207489,
-0.018445443361997604,
0.5201143026351929,
-0.8844295740127563,
0.8028842806816101,
0.45921972393989563,
0.5698754787445068,
-0.1624239683151245,
0.11118127405643463,
0.27016839385032654,
-0.9474307894706726,
0.30967840552330017,
0.08647767454385757,
-0.5012854337692261,
0.22135937213897705,
-0.5428902506828308,
0.4351697564125061,
-0.2793799340724945,
-0.053296495229005814,
0.5818493962287903,
-0.7098919153213501,
-0.49872735142707825,
0.678208589553833,
-0.41337570548057556,
0.9060286283493042,
-0.17860040068626404,
-0.47709453105926514,
0.7534680366516113,
-0.04194742441177368,
-0.5913751125335693,
-0.4048008918762207,
0.16932648420333862,
0.11402789503335953,
-0.8353096842765808,
-0.5622678995132446,
-0.1213739812374115,
-0.004702582955360413,
-0.30010414123535156,
0.1952723115682602,
0.15785826742649078,
0.5030287504196167,
-0.5451062321662903,
0.2552475929260254,
0.07903914153575897,
0.5436527132987976,
-0.34325796365737915,
-0.9061853289604187,
-0.11369173973798752,
-0.418541818857193,
0.11268611997365952,
-0.08631867170333862,
-0.3026427626609802,
0.15709145367145538,
0.9168342351913452,
-0.020988455042243004,
0.703910231590271,
0.4738937020301819,
0.13818655908107758,
0.8831360936164856,
-0.14986996352672577,
0.5660723447799683,
-0.1197875589132309,
-0.2782741189002991,
-0.3465259075164795,
-0.14850635826587677,
0.5982666611671448,
0.15393368899822235,
-0.11819767206907272,
-0.19282375276088715,
-0.24353499710559845,
-0.1992521584033966,
0.11693347990512848,
-0.8126329779624939,
-0.214498832821846,
-0.020689815282821655,
-0.479157954454422,
-0.5336157083511353,
0.18937450647354126,
-0.6658008694648743,
0.006547685246914625,
0.0033944975584745407,
0.47797268629074097,
0.4973504841327667,
-0.7351957559585571,
0.07896889746189117,
-0.44606801867485046,
-0.00046445580665022135,
0.3199809193611145,
0.11536608636379242,
-0.4298512041568756,
-0.519854724407196,
0.2094828188419342,
-0.13371868431568146,
0.20180743932724,
0.10600742697715759,
-0.3102211058139801,
-0.3199593126773834,
-0.33434242010116577,
0.4728658199310303,
0.2510332465171814,
0.8562250733375549,
-0.07414466142654419,
-0.762534499168396,
0.19003021717071533,
-0.7690142393112183,
-0.6436107754707336,
-0.017472630366683006,
0.6258246302604675,
-0.4571082890033722,
-0.023091524839401245,
-0.3166465759277344,
0.6398607492446899,
0.3010680675506592,
-0.5421500205993652,
-0.6017933487892151,
0.3517817258834839,
-0.039021700620651245,
-0.005022197496145964,
-0.24570238590240479,
0.23483137786388397,
-0.4929855763912201,
0.10107757896184921,
-0.18941941857337952,
0.20277944207191467,
0.6329265236854553,
-0.3944835364818573,
-0.12125946581363678,
0.10183293372392654,
0.49587222933769226,
-0.2757926881313324,
0.14724215865135193,
0.028300950303673744,
-0.22739727795124054,
0.08176735043525696,
-0.3711341321468353,
0.08733666688203812,
-0.05657896026968956,
0.03553652763366699,
-5.7742228507995605,
0.018358994275331497,
0.15947575867176056,
0.08759769052267075,
0.46204453706741333,
0.2482735514640808,
0.6951284408569336,
0.15820646286010742,
0.009108387865126133,
0.3495822846889496,
0.09401825070381165,
0.23291541635990143,
0.2865634262561798,
0.3314133882522583,
-0.23695646226406097,
-0.06770408898591995,
0.019418537616729736,
-0.3138714134693146,
0.43820375204086304,
0.10424317419528961,
0.2347797453403473,
-0.27804091572761536,
-0.06961219012737274,
0.9813334941864014,
-0.2038973718881607,
-0.4318377375602722,
-0.45906320214271545,
0.6610076427459717,
-0.15976737439632416,
0.08520902693271637,
-0.07301698625087738,
-0.6465144753456116,
0.4382946789264679,
0.14854060113430023,
-0.062418073415756226,
0.15215887129306793,
-0.19618098437786102,
-0.10564390569925308,
-0.3244817852973938,
-0.24722322821617126,
0.2191457897424698,
0.026388363912701607,
0.05694727227091789,
-0.14183872938156128,
0.45237526297569275,
0.18917594850063324,
0.04171387106180191,
-0.48714083433151245,
-0.2394343912601471,
0.7002538442611694,
0.4772208631038666,
0.15483982861042023,
0.9774516224861145,
0.3333281874656677,
0.5408675074577332,
-0.09494372457265854,
-0.014176677912473679,
-0.20218458771705627,
0.35337355732917786,
-0.13139194250106812,
-0.41393545269966125,
0.04335460811853409,
-0.3269532024860382,
-0.4152276813983917,
0.2749870717525482,
0.5587819218635559,
0.03327623009681702,
-0.6098485589027405,
0.6463677287101746,
-0.04412424936890602,
-0.6192408204078674,
0.6234133243560791,
0.22029127180576324,
-0.5955005884170532,
0.3432821035385132,
-0.063817098736763,
0.10946240276098251,
-0.0927978977560997,
0.2849271893501282,
-0.11617282032966614,
-0.22893109917640686,
0.18910248577594757,
-0.022048965096473694,
-0.752577006816864,
0.06326305121183395,
-0.31015920639038086,
-0.30957257747650146,
0.1905164271593094,
-0.21512781083583832,
0.7184457182884216,
0.8214344382286072,
0.039530493319034576,
0.09001059830188751,
0.27057787775993347,
0.4976811707019806,
0.6534573435783386,
0.16056250035762787,
0.5483293533325195,
0.45385265350341797,
0.18261224031448364,
0.61062091588974,
-0.010446703992784023,
-0.18952253460884094,
-0.47878581285476685,
-0.21100586652755737,
-0.3061397969722748,
-0.6253572106361389,
0.12064072489738464,
0.342774361371994,
-0.8002856373786926,
-0.07303224503993988,
0.756540060043335,
0.18742604553699493,
-0.9340027570724487,
0.1965385526418686,
0.11143358796834946,
0.0793052688241005,
0.16929860413074493,
1.0828864574432373,
-0.47010713815689087,
0.28246498107910156,
0.5629494786262512,
-0.6118670105934143,
0.03860598802566528,
0.17052756249904633,
-0.11885565519332886,
0.22921930253505707,
0.8013145327568054,
-0.10822764039039612,
-0.2587682604789734,
0.2755703032016754,
0.2574385106563568,
-0.20583954453468323,
0.07658621668815613,
-0.018701111897826195,
-0.16951438784599304,
-0.25032293796539307,
0.1698129028081894,
-0.49556246399879456,
-0.505796492099762,
0.20175808668136597,
-0.7179969549179077,
-0.10229577869176865,
-0.16664908826351166,
0.12712223827838898,
0.05657756328582764,
-0.19564169645309448,
-0.10039560496807098,
0.3390048146247864,
-0.17758920788764954,
0.19952459633350372,
0.09929338097572327,
0.02259117178618908,
0.3604004979133606,
-0.30540621280670166,
-0.005690944381058216,
0.2676396667957306,
-0.10341115295886993,
0.4551476538181305,
-0.8093456029891968,
0.20706743001937866,
-0.017174789682030678,
-1.020878553390503,
-0.31697016954421997,
-0.9400351047515869,
0.17591631412506104,
0.10036246478557587,
-0.8805770874023438,
-0.46419090032577515,
0.3177899420261383,
-0.5816228985786438,
-0.21843677759170532,
-0.28964748978614807,
-0.04422661289572716,
0.8027394413948059,
-0.361703485250473,
0.0017149386694654822,
-0.24016715586185455,
-0.25078946352005005,
-0.3017962574958801,
0.3056331276893616,
-0.8119443655014038,
0.07885347306728363,
0.32996124029159546,
0.5580084919929504,
-0.5985371470451355,
0.0715227723121643,
0.013252903707325459,
-0.6618059277534485,
-0.4885953664779663,
0.37219321727752686,
0.07382946461439133,
0.20170152187347412,
-0.270808607339859,
0.3309629261493683,
0.1345531940460205,
-0.2094675898551941,
0.36346203088760376,
0.17123255133628845,
-0.13259057700634003,
0.5069069266319275,
0.39511290192604065,
-0.5792813301086426,
0.2536144256591797,
0.4609871506690979,
0.09518633782863617,
-0.38441935181617737,
-0.17270031571388245,
-0.1837553083896637,
0.06679179519414902,
-0.23385001718997955,
-0.287492960691452,
-0.21905511617660522,
0.3416018486022949,
-0.2517107129096985,
0.1330106258392334,
0.07241344451904297,
0.08133228868246078,
-0.3814309537410736,
0.39591917395591736,
0.22599810361862183,
0.1507989466190338,
0.14863444864749908,
0.24425621330738068,
-0.5030571222305298,
0.22695578634738922,
0.47749757766723633,
-0.9226018190383911,
0.005108521319925785,
0.2522622048854828,
-0.18359002470970154,
-0.17596758902072906,
-0.12375795096158981,
-0.31292110681533813,
0.3530934154987335,
-0.6718410849571228,
0.5499163866043091,
0.396276593208313,
-0.321327805519104,
-0.04715400189161301,
0.09540300071239471,
0.3180370330810547,
-0.18931323289871216,
0.027803471311926842,
-0.0853445902466774,
0.4936501681804657,
0.13708113133907318,
-0.7199508547782898,
-0.6188356280326843,
0.12355563789606094,
0.46636682748794556,
0.22561900317668915,
0.05109022557735443,
0.23344138264656067,
0.33475634455680847,
-0.43947213888168335,
-0.3728700578212738,
-0.26482704281806946,
0.2659648060798645,
0.32887643575668335,
-0.21592679619789124,
-0.2028760015964508,
0.20752070844173431,
0.03423449397087097,
0.7889761924743652,
-0.16604506969451904,
-0.04868629574775696,
-0.33712345361709595,
0.2402079701423645,
-0.36747023463249207,
0.29894089698791504,
0.023562399670481682,
0.7859150767326355,
0.4450160562992096,
0.35113459825515747,
0.3338516056537628,
-0.3273417353630066,
-0.4788679778575897,
-0.23784151673316956,
0.48360350728034973,
0.05646657198667526,
-0.4969113767147064,
0.13313457369804382,
-0.21730937063694,
0.5743739008903503,
-0.9377818703651428,
0.5818783044815063,
-0.47968077659606934,
-0.301394522190094,
-0.4495508372783661,
-0.2210512012243271,
0.015923555940389633,
0.019049478694796562,
-0.31924203038215637,
-0.16624708473682404,
0.15860877931118011,
0.15459220111370087,
0.22777588665485382,
-0.14959514141082764,
-0.556245744228363,
-0.5526404976844788,
-0.14038623869419098,
0.7679633498191833,
-0.6019923686981201,
-0.17907926440238953,
0.45414096117019653,
0.18853095173835754,
-0.2580416202545166,
-1.1077193021774292,
0.019724825397133827,
0.4133751094341278,
-0.07139436155557632,
-0.04430614411830902,
0.35592854022979736,
-0.04637737572193146,
0.29156410694122314,
-0.3213186264038086,
-0.27139315009117126,
0.26224642992019653,
0.015292761847376823,
0.29768314957618713,
0.1573086827993393,
-0.28936177492141724,
-0.4096091389656067,
0.17990800738334656,
0.09365855902433395,
0.2964600622653961,
0.3196347951889038,
-0.18413536250591278,
0.5653977394104004,
0.7848080992698669,
0.2008555382490158,
0.10454526543617249,
0.8459697365760803,
0.17450277507305145,
0.07908007502555847,
0.021962406113743782,
-0.8869356513023376,
-0.363815575838089,
0.4773157835006714,
0.722492516040802,
0.0870077908039093,
-0.12040126323699951,
0.22599545121192932,
0.19409115612506866,
0.5786317586898804,
0.2549198269844055,
-0.044860851019620895,
-0.14308768510818481,
0.27874720096588135,
0.252519816160202,
-0.38232389092445374,
-0.26974746584892273,
0.03518574684858322,
-0.4543793797492981,
-0.20849359035491943,
0.7297040224075317,
-0.21447919309139252,
0.037362027913331985,
0.18933285772800446,
-0.07694065570831299,
0.6353276371955872,
-0.40693899989128113,
0.26920086145401,
0.2538430094718933,
-0.0824257880449295,
0.522031843662262,
-0.8057025074958801,
0.47243231534957886,
0.26132506132125854,
0.13255929946899414,
-0.11328966170549393,
-0.2961800694465637,
-0.16061635315418243,
0.5855967402458191,
-0.6775497198104858,
0.534578263759613,
0.5344588756561279,
0.014036227948963642,
0.5831950902938843,
-0.2946641445159912,
0.0880768895149231,
-0.23827248811721802,
-0.5252054929733276,
-0.18656045198440552,
0.14465749263763428,
-0.3995099365711212,
-0.25575900077819824,
0.32326385378837585,
0.169846773147583,
0.18351110816001892,
-0.3595409095287323,
-0.029912125319242477,
0.4210534989833832,
0.3496882915496826,
0.02969055436551571,
0.20173564553260803,
0.0306920874863863,
0.2358584702014923,
-0.11253020167350769,
-0.04459900036454201,
0.3885155916213989,
-0.15754841268062592,
0.36125245690345764,
-0.8859837055206299,
0.5375961661338806,
-0.26439759135246277,
-0.3361164927482605,
-0.5802081227302551,
0.3685014545917511,
0.9764058589935303,
0.7435488104820251,
-0.08356451988220215,
0.2036985456943512,
0.6797590851783752,
-0.06508510559797287,
-0.010399475693702698,
-0.5516525506973267,
-0.17544415593147278,
-0.7574174404144287,
0.683845579624176,
-0.4210224449634552,
0.5853758454322815,
-0.2877344489097595,
-0.28743746876716614,
0.31143292784690857,
0.5914304852485657,
0.2577415108680725,
-0.12641650438308716,
0.715517520904541,
-0.5230023264884949,
0.2389935851097107,
-0.7480201125144958,
0.2249792516231537,
-0.14940591156482697,
0.10726307332515717,
0.06913653761148453,
0.03822382539510727,
0.06442022323608398,
-0.42483463883399963,
0.21083848178386688,
0.08682698756456375,
-0.009632757864892483,
-0.18992848694324493,
-0.12503491342067719,
0.17929604649543762,
0.024752233177423477,
-0.0947878360748291,
-0.566866397857666,
-0.025324499234557152,
0.10294504463672638,
-0.35095134377479553,
-0.09766457974910736,
0.3296027183532715,
0.21646781265735626,
-0.5416328310966492,
-0.2892572283744812,
-0.19762840867042542,
-0.24673615396022797,
0.0743894875049591
] |
BACKGROUND microRNAs (miRNAs) stably exist in circulating blood and are encapsulated in extracellular vesicles such as exosomes. The aims of this study were to identify which exosomal miRNAs are highly produced from epithelial ovarian cancer (EOC) cells, to analyze whether serum miRNA can be used to discriminate patients with EOC from healthy volunteers, and to investigate the functional role of exosomal miRNAs in ovarian cancer progression. METHODS Exosomes were collected from the culture media of serous ovarian cancer cell lines, namely TYK-nu and HeyA8 cells. An exosomal miRNA microarray revealed that several miRNAs including miR-99a-5p were specifically elevated in EOC-derived exosomes. Expression levels of serum miR-99a-5p in 62 patients with EOC, 26 patients with benign ovarian tumors, and 20 healthy volunteers were determined by miRNA quantitative reverse transcription-polymerase chain reaction. To investigate the role of exosomal miR-99a-5p in peritoneal dissemination, neighboring human peritoneal mesothelial cells (HPMCs) were treated with EOC-derived exosomes and then expression levels of miR-99a-5p were examined. Furthermore, mimics of miR-99a-5p were transfected into HPMCs and the effect of miR-99a-5p on cancer invasion was analyzed using a 3D culture model. Proteomic analysis with the tandem mass tag method was performed on HPMCs transfected with miR-99a-5p and then potential target genes of miR-99a-5p were examined. RESULTS The serum miR-99a-5p levels were significantly increased in patients with EOC, compared with those in benign tumor patients and healthy volunteers (1.7-fold and 2.8-fold, respectively). A receiver operating characteristic curve analysis showed with a cut-off of 1.41 showed sensitivity and specificity of 0.85 and 0.75, respectively, for detecting EOC (area under the curve = 0.88). Serum miR-99a-5p expression levels were significantly decreased after EOC surgeries (1.8 to 1.3, p = 0.002), indicating that miR-99a-5p reflects tumor burden. Treatment with EOC-derived exosomes significantly increased miR-99a-5p expression in HPMCs. HPMCs transfected with miR-99a-5p promoted ovarian cancer invasion and exhibited increased expression levels of fibronectin and vitronectin. CONCLUSIONS Serum miR-99a-5p is significantly elevated in ovarian cancer patients. Exosomal miR-99a-5p from EOC cells promotes cell invasion by affecting HPMCs through fibronectin and vitronectin upregulation and may serve as a target for inhibiting ovarian cancer progression. | [
0.026612866669893265,
0.007558209355920553,
-0.003939779940992594,
0.018279746174812317,
0.004605868831276894,
0.0007925017271190882,
0.010730745270848274,
0.015086482279002666,
-0.017369993031024933,
-0.010115516372025013,
-0.004088053945451975,
0.008995912037789822,
0.013848621398210526,
0.0106563251465559,
-0.016375748440623283,
0.015676677227020264,
-0.024445582181215286,
-0.014185672625899315,
0.01389441080391407,
0.046301230788230896,
0.029203472658991814,
-0.010648293420672417,
0.01008641067892313,
-0.023297298699617386,
0.01376783661544323,
0.031594790518283844,
-0.02032322622835636,
-0.021140193566679955,
-0.0033657774329185486,
0.01056558359414339,
0.037411823868751526,
-0.010723668150603771,
0.02060832642018795,
-0.015781400725245476,
0.0030772138852626085,
-0.03161017596721649,
-0.004853484220802784,
0.024477936327457428,
0.02421877160668373,
-0.00478280009701848,
0.019984405487775803,
-0.01151183620095253,
0.0025165483821183443,
-0.005981995724141598,
-0.008773751556873322,
-0.009726384654641151,
-0.006727393716573715,
0.015611168928444386,
0.004728267434984446,
0.00111418217420578,
-0.008525259792804718,
-0.0067571233958005905,
-0.021347224712371826,
-0.011464963667094707,
-0.007221787236630917,
0.01040133647620678,
0.01932322233915329,
0.007150302641093731,
0.0027368259616196156,
0.028891010209918022,
-0.00014177942648530006,
-0.01773194596171379,
-0.01521856989711523,
0.004240524023771286,
-0.025861172005534172,
-0.06677471846342087,
0.010764207690954208,
-0.0022100689820945263,
0.008300102315843105,
-0.02062094584107399,
0.02066454291343689,
0.010219395160675049,
0.01748041994869709,
0.0030035481322556734,
-0.0006304699927568436,
-0.0052015273831784725,
-0.01118480134755373,
-0.02817150577902794,
0.009683511219918728,
-0.0012443093582987785,
0.03743375837802887,
0.007932686246931553,
-0.04206611216068268,
-0.017179828137159348,
0.015251625329256058,
0.011429288424551487,
-0.037939295172691345,
0.012994490563869476,
0.0008877310901880264,
-0.010132682509720325,
-0.016067996621131897,
0.04308491200208664,
-0.04786137491464615,
-0.010163542814552784,
-0.03409314900636673,
0.013716669753193855,
0.006294148974120617,
-0.034532856196165085,
-0.006735437083989382,
-0.005574498325586319,
-0.013100000098347664,
0.020074885338544846,
0.014718218706548214,
0.03108207881450653,
-0.0053488584235310555,
0.017716407775878906,
0.023959802463650703,
-0.011022206395864487,
-0.012573323212563992,
0.007346428465098143,
-0.006019783206284046,
-0.03236356005072594,
-0.00461993832141161,
-0.017233574762940407,
-0.012357513420283794,
-0.019983284175395966,
0.011751013807952404,
0.010785141959786415,
0.006477721035480499,
0.0204286091029644,
0.017359286546707153,
-0.012464133091270924,
0.00345960957929492,
0.01762254908680916,
0.004148605279624462,
-0.00819283165037632,
0.0025359473656862974,
-0.005702924448996782,
-0.007052562665194273,
-0.021361643448472023,
-0.00965395849198103,
0.0062590092420578,
0.008963380008935928,
-0.04783978313207626,
-0.027987755835056305,
0.005764711648225784,
0.028035279363393784,
-0.005465726368129253,
0.0003073364496231079,
-0.014651365578174591,
0.003963066730648279,
0.007843760773539543,
0.0031164884567260742,
0.01144818589091301,
0.027012985199689865,
0.008614429272711277,
-0.03541557863354683,
-0.009180469438433647,
0.011450143530964851,
-0.03448932617902756,
0.020478811115026474,
-0.004835452884435654,
-0.00425997469574213,
-0.0083682332187891,
0.04902074113488197,
-0.01852363348007202,
-0.03415929153561592,
-0.00888865627348423,
-0.004193570464849472,
-0.007437958847731352,
-0.04015855863690376,
-0.013876013457775116,
0.017434002831578255,
0.012035593390464783,
-0.004451273009181023,
-0.0243426151573658,
0.022360827773809433,
0.009265907108783722,
0.016570542007684708,
0.0039107222110033035,
-0.006898947060108185,
-0.002995316172018647,
0.017929403111338615,
0.0063843270763754845,
0.001421388704329729,
0.001191339222714305,
-0.0007127008866518736,
0.008824103511869907,
-0.015397327020764351,
0.06661693751811981,
-0.025363381952047348,
0.038262102752923965,
0.013242197223007679,
0.016295848414301872,
0.005846671760082245,
-0.013273590244352818,
-0.006717201787978411,
-0.006730563938617706,
0.0008499030955135822,
0.010745220817625523,
0.006179817020893097,
-0.015370819717645645,
-0.035745080560445786,
0.0010956386104226112,
-0.06544679403305054,
0.003849433036521077,
0.017561405897140503,
0.020653653889894485,
-0.022699842229485512,
-0.03178531676530838,
0.010273146443068981,
-0.008353509940207005,
0.014468610286712646,
0.02850734069943428,
-0.0017414879985153675,
0.012029281817376614,
0.011781273409724236,
-0.048088643699884415,
-0.014098268002271652,
0.027710918337106705,
0.02874668501317501,
-0.005284915212541819,
0.0020352895371615887,
-0.017465095967054367,
0.023224402219057083,
0.004877092316746712,
0.012766925618052483,
0.03548157960176468,
-0.0247473306953907,
-0.01449398510158062,
-0.005106706637889147,
0.009483988396823406,
0.0037867389619350433,
0.010232150554656982,
0.006234829314053059,
-0.01458531804382801,
0.024837540462613106,
0.010501578450202942,
0.004081869497895241,
0.007461352273821831,
-0.022181805223226547,
-0.04969709366559982,
-0.013678139075636864,
0.006503968499600887,
0.002853923477232456,
-0.026269763708114624,
0.0130574069917202,
0.003953453153371811,
0.004516978282481432,
-0.006522882729768753,
0.025234606117010117,
-0.0018102871254086494,
0.004392390605062246,
-0.0016664620488882065,
0.0020343996584415436,
-0.002604468259960413,
0.02164081670343876,
0.019769858568906784,
0.04246789216995239,
0.00396039430052042,
0.009211561642587185,
-0.03047853335738182,
0.01112312451004982,
-0.018458524718880653,
0.03986744582653046,
0.0049662538804113865,
-0.018131054937839508,
0.01783149689435959,
0.025015713647007942,
-0.024805093184113503,
-0.004844167735427618,
0.0037724170833826065,
-0.019939936697483063,
-0.000005305744707584381,
0.015352844260632992,
0.02215949445962906,
-0.01026654802262783,
0.0013425524812191725,
0.007507755421102047,
-0.028828151524066925,
0.011950649321079254,
-0.0019812905229628086,
0.00894102267920971,
-0.08122232556343079,
-0.004241918213665485,
0.03394973278045654,
-0.04353449493646622,
0.009506722912192345,
0.000741192139685154,
-0.004754800349473953,
0.018676917999982834,
0.0026477170176804066,
0.004708175081759691,
-0.029482150450348854,
0.022335754707455635,
-0.013956598937511444,
-0.009442484006285667,
-0.03533373773097992,
-0.000852054450660944,
0.017021894454956055,
0.010370486415922642,
-0.004308465868234634,
-0.020313629880547523,
-0.02655118703842163,
0.00607798807322979,
-0.014637154527008533,
0.025924069806933403,
-0.013727361336350441,
-0.0009681594092398882,
0.0073766885325312614,
0.003949390258640051,
-0.007734942249953747,
0.0027590030804276466,
-0.03504885360598564,
-0.026133790612220764,
0.013708215206861496,
0.0023266500793397427,
0.0036772501189261675,
0.024215174838900566,
0.002290403936058283,
0.016492025926709175,
-0.019960302859544754,
0.023705417290329933,
-0.007463553920388222,
0.01982598938047886,
0.034341197460889816,
-0.009262126870453358,
0.0066723148338496685,
0.0013868429232388735,
0.0004180101677775383,
0.051608167588710785,
0.01651020161807537,
-0.020459141582250595,
0.0018898029811680317,
-0.001769316615536809,
0.019026685506105423,
0.020855342969298363,
-0.018945394083857536,
0.025422200560569763,
-0.05457838997244835,
-0.008895368315279484,
-0.009135859087109566,
-0.0004637804813683033,
-0.001671358710154891,
0.0006589284166693687,
0.007737929467111826,
0.013387955725193024,
-0.019955027848482132,
0.028158271685242653,
0.025864575058221817,
0.01041749119758606,
0.0039011011831462383,
0.020153848454356194,
-0.013305111788213253,
-0.010054850950837135,
0.01148901041597128,
-0.014557535760104656,
-0.031275831162929535,
-0.008089616894721985,
-0.012625852599740028,
0.0018251269357278943,
-0.009376359172165394,
-0.01425737701356411,
-0.02937200292944908,
-0.007597555872052908,
-0.01869046874344349,
-0.029957976192235947,
-0.024421963840723038,
0.009060170501470566,
0.013670796528458595,
0.04478134587407112,
-0.0012666545808315277,
-0.018878743052482605,
0.004276374354958534,
0.009433455765247345,
-0.0006507316138595343,
0.010426186956465244,
-0.010389954783022404,
-0.01488194614648819,
-0.0010488592088222504,
0.013907584361732006,
0.017450492829084396,
0.008175678551197052,
-0.021072547882795334,
-0.0030221878550946712,
0.0036513768136501312,
-0.011454561725258827,
-0.02662736549973488,
0.013829870149493217,
0.001349627273157239,
-0.01890999637544155,
0.0038703428581357002,
0.00498674251139164,
-0.005520188715308905,
-0.00004753191024065018,
-0.014292486943304539,
0.023385949432849884,
0.014665760099887848,
0.015012959018349648,
0.005070280283689499,
-0.007682705298066139,
0.07150765508413315,
0.013135792687535286,
-0.005853292532265186,
-0.023373890668153763,
0.013163113966584206,
-0.026160091161727905,
-0.030710645020008087,
-0.008322562091052532,
-0.021256443113088608,
-0.010058213956654072,
0.013172678649425507,
-0.014886505901813507,
-0.004913080483675003,
-0.007338453084230423,
-0.016210490837693214,
-0.013211994431912899,
-0.0149197643622756,
-0.0404396653175354,
0.01099042035639286,
0.03784296661615372,
-0.022884730249643326,
0.03778877109289169,
-0.024670980870723724,
-0.008471597917377949,
-0.008345894515514374,
-0.003649066900834441,
-0.017956290394067764,
-0.013753869570791721,
-0.02136939764022827,
0.0099452780559659,
0.016574829816818237,
0.02235635370016098,
-0.008519725874066353,
-0.010185418650507927,
-0.0019455887377262115,
-0.0008734771981835365,
0.009307630360126495,
-0.02322540059685707,
-0.013171548023819923,
-0.005614239256829023,
0.0003007771447300911,
-0.006256362423300743,
-0.001887585036456585,
0.016966059803962708,
0.010019464418292046,
-0.03453642502427101,
0.020305680111050606,
-0.011010179296135902,
0.019661549478769302,
-0.006996769458055496,
0.0023120706900954247,
0.010202240198850632,
0.011652275919914246,
-0.008260373026132584,
-0.030867591500282288,
-0.026337115094065666,
0.02026425302028656,
0.009784618392586708,
0.019074419513344765,
0.009789975360035896,
-0.022066952660679817,
0.016120295971632004,
0.013513784855604172,
0.014181355945765972,
0.0037004987243562937,
-0.011268637143075466,
-0.02137373946607113,
0.01050602737814188,
-0.002609716262668371,
-0.04666341096162796,
-0.010057864710688591,
0.0436747744679451,
-0.015398330055177212,
0.0022505701053887606,
-0.022289562970399857,
-0.03855046257376671,
0.010297853499650955,
-0.015650425106287003,
0.01786353997886181,
0.026405440643429756,
0.004995533265173435,
0.001329474151134491,
-0.005223052576184273,
0.014438529498875141,
-0.012212461791932583,
-0.023971490561962128,
-0.016335148364305496,
-0.07412277162075043,
-0.034930188208818436,
-0.00671292282640934,
-0.0005706754745915532,
0.02936580404639244,
-0.00339732738211751,
-0.009966599754989147,
0.04046089947223663,
-0.0023065987043082714,
-0.006965890992432833,
0.01152161043137312,
0.002633150666952133,
0.024710405617952347,
-0.0015359614044427872,
0.012422426603734493,
-0.011863870546221733,
0.04127403348684311,
-0.011482924222946167,
0.003517653327435255,
0.0013637426309287548,
0.004348559305071831,
0.03533139079809189,
-0.014645912684500217,
0.011879481375217438,
-0.012848760932683945,
-0.08028420805931091,
-0.007760224863886833,
0.01868913322687149,
0.008398216217756271,
-0.002784349489957094,
0.02731049805879593,
0.010256240144371986,
0.013699685223400593,
0.005456002429127693,
-0.018548626452684402,
0.010463239625096321,
0.01922430470585823,
0.02644309774041176,
0.0046000792644917965,
0.0022852704860270023,
-0.007739579770714045,
0.011460741050541401,
0.001384157221764326,
-0.04330453276634216,
0.018284406512975693,
0.012648839503526688,
0.011511359363794327,
-0.007660881616175175,
-0.0007031566929072142,
-0.008488250896334648,
0.009821372106671333,
0.01639533042907715,
0.015436586923897266,
0.003765304572880268,
0.012322213500738144,
-0.016039490699768066,
0.014290954917669296,
-0.006683655548840761,
0.010160107165575027,
-0.0030268067494034767,
-0.029054857790470123,
-0.013368875719606876,
-0.0007545171538367867,
-0.029417162761092186,
-0.010832464322447777,
-0.012455490417778492,
0.002985374303534627,
-0.0032166617456823587,
-0.008734102360904217,
-0.02536494843661785,
-0.028988972306251526,
0.009688512422144413,
-0.007680902257561684,
0.01218679454177618,
-0.014060392044484615,
0.006323439069092274,
0.004864685703068972,
-0.02115033008158207,
-0.007562394719570875,
0.011447936296463013,
0.02266744151711464,
0.005279639735817909,
0.006318584084510803,
0.010290632955729961,
0.008674321696162224,
-0.00636266078799963,
0.02789974957704544,
-0.023480787873268127,
0.07139034569263458,
0.012970288284122944,
0.01919865421950817,
-0.002007056027650833,
-0.00880755577236414,
0.00588203314691782,
-0.0023135384544730186,
-0.02860722690820694,
-0.004208642989397049,
0.007924620062112808,
0.018664252012968063,
0.002899942919611931,
-0.005417021922767162,
0.017115935683250427,
-0.00015922915190458298,
-0.006781475152820349,
-0.013158670626580715,
0.011881159618496895,
-0.029599595814943314,
0.024031655862927437,
0.0027373181656003,
-0.036962106823921204,
-0.030532408505678177,
-0.03062053769826889,
0.002124698366969824,
0.006873766891658306,
-0.02449546754360199,
0.022306177765130997,
-0.016107235103845596,
0.043171755969524384,
-0.005754463374614716,
0.008871553465723991,
0.0007295567193068564,
0.026897232979536057,
0.03879954293370247,
0.019931258633732796,
0.0029865482356399298,
0.007811045274138451,
0.0004091886803507805,
-0.0034879944287240505,
0.016358815133571625,
-0.012990874238312244,
-0.0017131456406787038,
0.0033770697191357613,
-0.0005516540259122849,
-0.028725311160087585,
-0.012919819913804531,
0.00186449708417058,
-0.003448457457125187,
0.007966330274939537,
-0.019957710057497025,
0.00040426955092698336,
-0.00862167589366436,
-0.03228886052966118,
-0.0014706971123814583,
-0.008485503494739532,
0.020926760509610176,
0.027131337672472,
0.0032103920821100473,
0.03243429958820343,
0.007232357282191515,
-0.011689863167703152,
0.022642649710178375,
-0.020740512758493423,
0.007684727199375629,
-0.04294077679514885,
0.013866685330867767,
0.0039556585252285,
-0.025311686098575592,
0.016278885304927826,
-0.029206834733486176,
-0.004731141030788422,
0.008952082134783268,
0.024523984640836716,
0.011080006137490273,
-0.0069364202208817005,
0.03420428931713104,
0.0007048775441944599,
0.022977817803621292,
0.037642400711774826,
-0.0004564281553030014,
0.03362924978137016,
0.012353260070085526,
0.001786665292456746,
-0.05417304486036301,
-0.0006948825903236866,
0.0018721697852015495,
-0.014962749555706978,
0.00426139822229743,
0.019529616460204124,
0.010603790171444416,
0.0012222770601511002,
0.00972963310778141,
0.033216699957847595,
0.010913435369729996,
0.03461039066314697,
0.009076982736587524,
0.004562806338071823,
-0.0001612131018191576,
0.022789182141423225,
0.014717989601194859,
0.01769183576107025,
-0.02172413468360901,
0.007928973063826561,
0.006877942010760307,
0.003027823753654957,
0.004793080501258373,
0.025880102068185806,
0.009310874156653881,
0.001511414535343647,
0.03210395947098732,
-0.01162015087902546,
-0.006077321246266365,
-0.020584436133503914,
0.0018129384843632579,
0.02760513499379158,
-0.00414272490888834,
0.024416755884885788,
-0.003549656830728054,
-0.01627732440829277,
-0.0008934778161346912,
-0.025591785088181496,
0.01658431626856327,
0.010006647557020187,
-0.0013468244578689337,
-0.019320303574204445,
-0.001179143087938428,
-0.0027831168845295906,
0.0017720065079629421,
-0.017512623220682144,
0.024678604677319527,
0.005330783315002918,
-0.028585124760866165,
-0.009016670286655426,
-0.024918673560023308,
0.0017789576668292284,
0.007625297177582979,
-0.0001635747030377388,
-0.013119249604642391,
-0.00809346605092287,
-0.0018204685766249895,
-0.026045385748147964,
-0.0015608426183462143,
-0.016064537689089775,
0.010013734921813011,
0.013587134890258312,
0.007340841926634312,
-0.0015168781392276287,
0.0022568688727915287,
0.007077858783304691,
-0.004505096469074488,
0.014563273638486862,
0.010577723383903503,
-0.009372844360768795,
0.0190921351313591,
0.007824065163731575,
-0.006002665031701326,
0.005272009875625372,
-0.009744362905621529,
-0.004528359044343233,
0.006434433627873659,
0.006124360021203756,
0.02321309968829155,
0.010708778165280819,
0.0014800922945141792,
0.010000662878155708,
-0.02404654771089554,
0.0025842697359621525,
0.014185682870447636,
-0.005896030925214291,
0.009710032492876053,
0.0025994558818638325,
0.014944937080144882,
0.03980185091495514,
-0.03202392905950546,
-0.001402307185344398,
-0.011754725128412247,
-0.02300333045423031,
0.022127777338027954,
-0.02074739895761013,
-0.03134886920452118,
-0.01999347098171711,
0.02185465767979622,
-0.0071061747148633,
-0.0016479345504194498,
-0.013568875379860401,
-0.0051787421107292175,
0.004775437526404858,
0.003721333807334304,
0.018315011635422707,
-0.02446095645427704,
0.03167331963777542,
-0.024854762479662895,
0.020434550940990448,
-0.035968318581581116,
0.01285441592335701,
-0.01615946926176548,
-0.011401700787246227,
-0.0038100352976471186,
0.012580960057675838,
0.002875698497518897,
0.0031764646992087364
] | [
0.3758772909641266,
-0.07976234704256058,
0.07024213671684265,
0.26392149925231934,
0.3497321903705597,
0.32887932658195496,
0.11033035814762115,
0.13668414950370789,
-0.1025266945362091,
-0.29238390922546387,
0.2681533396244049,
-0.02429441548883915,
-0.23530113697052002,
0.04446433112025261,
-0.11272226274013519,
0.4558104872703552,
0.2757607698440552,
0.46508148312568665,
0.11136426776647568,
-0.6967014074325562,
-0.2965319752693176,
-0.3106100559234619,
0.5742972493171692,
-0.06683367490768433,
0.11155858635902405,
-0.0015274201286956668,
0.4429928660392761,
-0.04960155487060547,
0.4437532126903534,
-0.08514570444822311,
-0.14884892106056213,
0.7499908208847046,
0.21394407749176025,
-0.22435308992862701,
0.0014026457211002707,
-0.4846060574054718,
-0.44767382740974426,
0.444129079580307,
0.02868851087987423,
-0.20492678880691528,
-0.29586267471313477,
-0.23624131083488464,
-0.12507137656211853,
0.7844104766845703,
-0.26970282196998596,
-0.4065419137477875,
-1.2587065696716309,
1.0749351978302002,
-0.3545304536819458,
0.09908188134431839,
0.30634230375289917,
0.3165704309940338,
0.6094396710395813,
0.194579616189003,
0.1345715969800949,
0.30663400888442993,
-0.438152939081192,
-0.26755768060684204,
0.2520572245121002,
-0.4972835183143616,
-0.3153332769870758,
-0.03964867442846298,
-0.11996500939130783,
0.0714057981967926,
-0.06533898413181305,
0.41896942257881165,
0.21582038700580597,
-0.5086421966552734,
0.05890261009335518,
-0.3533826768398285,
0.26334884762763977,
-0.001357800094410777,
-0.3594505488872528,
0.15322399139404297,
-0.06030813604593277,
0.23840829730033875,
0.1501747965812683,
0.25380173325538635,
0.1871640980243683,
-0.0056096408516168594,
-0.12304673343896866,
-0.2238483875989914,
0.01129196397960186,
-0.22521837055683136,
0.5970091819763184,
0.08533713966608047,
-0.47809427976608276,
0.4566868245601654,
-0.15757976472377777,
-0.14848659932613373,
-0.1583152711391449,
-0.2164737582206726,
0.4149620234966278,
0.7304762601852417,
0.2341134250164032,
0.3474392890930176,
-0.26657068729400635,
-0.09744151681661606,
0.30131450295448303,
0.345537394285202,
-0.7769635915756226,
0.29569771885871887,
-0.10661790519952774,
-0.43601346015930176,
-0.4668992757797241,
0.002639240585267544,
-0.07716060429811478,
-0.15733352303504944,
-0.7057498693466187,
0.3710620701313019,
-0.48971521854400635,
-0.01548241451382637,
-0.24672424793243408,
-0.0494905523955822,
0.012914012186229229,
-0.03597528859972954,
0.3061748445034027,
-0.7149829268455505,
0.009559517726302147,
0.4778067469596863,
-0.3058859407901764,
1.6134183406829834,
-0.07096198946237564,
0.27955684065818787,
-0.003374815918505192,
0.162329763174057,
0.5819146037101746,
-0.18598446249961853,
-0.15971200168132782,
0.7699772715568542,
0.5007807016372681,
1.0876350402832031,
-0.3441436290740967,
0.40642645955085754,
0.14724646508693695,
-0.2600039839744568,
0.10695160925388336,
0.3326287567615509,
0.6481121778488159,
0.34952542185783386,
-0.8065890669822693,
-0.6444406509399414,
-0.06115153804421425,
0.023155169561505318,
0.1536441445350647,
-0.544664740562439,
-0.3976636528968811,
-0.4903605580329895,
-0.10679030418395996,
-0.08694034814834595,
-0.22270028293132782,
-0.5128212571144104,
-0.4946475028991699,
-0.5243415832519531,
-0.2786106467247009,
0.260429710149765,
-0.06258706003427505,
0.05996239185333252,
-0.31884804368019104,
0.41715753078460693,
0.25077560544013977,
0.46009308099746704,
-0.7030794620513916,
-0.20199993252754211,
0.3985934555530548,
-0.0656045526266098,
0.25448840856552124,
0.3869764506816864,
-0.03626984357833862,
0.2503454387187958,
-0.22338999807834625,
-0.33275434374809265,
0.09226121753454208,
-0.7419601082801819,
-0.04065147414803505,
0.024153046309947968,
0.21273651719093323,
-0.5041466951370239,
0.22130180895328522,
-0.007016985677182674,
-0.6557276844978333,
0.148183211684227,
0.06823787838220596,
-0.5527817010879517,
0.2091832309961319,
0.399262398481369,
0.37950384616851807,
0.12930555641651154,
0.025233836844563484,
-0.24458855390548706,
-0.6676344871520996,
-0.4844151735305786,
0.44492536783218384,
-0.6689284443855286,
1.5816130638122559,
-0.5011844038963318,
0.321284681558609,
1.2432279586791992,
0.09115391224622726,
-0.1470644325017929,
-0.23432126641273499,
-0.015375467017292976,
0.6245043873786926,
-0.5469599366188049,
-0.574281632900238,
-0.08913690596818924,
0.10560455173254013,
-0.4309096336364746,
0.10261394828557968,
-0.3382638096809387,
0.3210102915763855,
-0.019303828477859497,
0.0016184438718482852,
-0.2367403358221054,
0.004699081648141146,
0.006886040326207876,
-0.4766980707645416,
0.1399121731519699,
-0.10123703628778458,
-0.07250778377056122,
0.7344928979873657,
-0.6162711381912231,
0.8033281564712524,
0.3669753968715668,
-0.1977088302373886,
0.7356885075569153,
0.34715473651885986,
0.050342366099357605,
0.7016823291778564,
-0.24861013889312744,
0.5819925665855408,
-0.5581503510475159,
-0.019115174189209938,
-0.7166757583618164,
-0.15634743869304657,
-0.11358383297920227,
0.05114945396780968,
0.25634804368019104,
0.04697239026427269,
0.06987705081701279,
-0.25137758255004883,
0.6764524579048157,
-0.8750721216201782,
-0.3677806258201599,
-0.3917200565338135,
-0.5538835525512695,
-0.3883199989795685,
-0.30747008323669434,
-0.7297791242599487,
0.1529633104801178,
-0.12305355817079544,
-0.1257372796535492,
-0.08741483092308044,
-0.3479510545730591,
-0.20461037755012512,
0.14893022179603577,
-0.12179315090179443,
-0.6694865822792053,
0.3010604977607727,
-0.2125614583492279,
0.07347103208303452,
0.09261082112789154,
0.21302101016044617,
0.3358366787433624,
0.15024150907993317,
-0.6098762154579163,
-0.1451559066772461,
-0.5236851572990417,
1.2784725427627563,
0.7493719458580017,
0.7721884250640869,
0.2390345335006714,
-0.7644663453102112,
0.03671617433428764,
0.24125829339027405,
-0.7612622976303101,
0.2311694324016571,
1.057654857635498,
-0.28865471482276917,
-0.4074796438217163,
-0.23848626017570496,
0.1619454175233841,
0.7661003470420837,
-0.24209994077682495,
-0.058350592851638794,
-0.2574019730091095,
-0.24166260659694672,
0.13227272033691406,
-0.34815409779548645,
-0.09558138996362686,
-0.4756990969181061,
0.4605466425418854,
-0.618958592414856,
-0.14028142392635345,
0.4498842656612396,
0.3955663740634918,
0.054124586284160614,
0.49713438749313354,
0.5462408065795898,
0.19001789391040802,
-0.251893550157547,
0.31958040595054626,
0.017854735255241394,
-0.19246135652065277,
-0.23687931895256042,
0.4004920721054077,
-0.2860065698623657,
0.004461771808564663,
-5.691023826599121,
0.6890430450439453,
-0.1897432506084442,
-0.518447756767273,
0.14649176597595215,
0.17562568187713623,
1.1537811756134033,
0.02566693164408207,
0.5118144154548645,
-0.051345814019441605,
-0.01837768405675888,
0.30103859305381775,
-0.1706506758928299,
0.18724237382411957,
0.11373197287321091,
0.04287377744913101,
-0.07537776976823807,
-0.12041617929935455,
0.865340530872345,
0.2412402480840683,
-0.04550424590706825,
-0.2612755000591278,
-0.03456598520278931,
0.5376881957054138,
0.09793969243764877,
0.06994518637657166,
-1.0195965766906738,
0.02817700244486332,
0.03895019739866257,
-0.5671851634979248,
0.2883913815021515,
-1.0260299444198608,
-0.09996327012777328,
-0.34788528084754944,
-0.022635936737060547,
-0.158171147108078,
-0.031872816383838654,
0.012861663475632668,
0.20087841153144836,
-0.3270516097545624,
0.20277322828769684,
0.4371524155139923,
-0.1429595798254013,
-0.2772643268108368,
0.11774315685033798,
0.22685253620147705,
-0.10748279839754105,
0.33119598031044006,
-0.20189113914966583,
0.906116783618927,
-0.06772352010011673,
-0.10091082751750946,
0.395042359828949,
0.44657957553863525,
0.23227782547473907,
0.2265472412109375,
0.07135332375764847,
0.2277800589799881,
-0.3985990583896637,
0.07910969853401184,
-0.08754309266805649,
0.035244908183813095,
0.012152704410254955,
-0.7049967050552368,
-0.14154502749443054,
0.06787081807851791,
-1.0171103477478027,
-0.1467542201280594,
0.23096688091754913,
-0.2459736466407776,
-0.18999479711055756,
0.04989265650510788,
-0.13379959762096405,
-0.510338544845581,
0.324917733669281,
-0.21953712403774261,
0.13428525626659393,
0.00724082300439477,
0.1387031227350235,
-0.1967010647058487,
-0.30605435371398926,
-0.0966402143239975,
0.18923425674438477,
-0.2376895546913147,
0.1947328895330429,
-0.22596117854118347,
-0.3568025231361389,
-0.5255186557769775,
-0.25124645233154297,
0.11843280494213104,
0.3326908051967621,
-0.48652470111846924,
0.017397664487361908,
0.47970589995384216,
0.9085896015167236,
0.24895983934402466,
0.6517184376716614,
0.47534096240997314,
0.5305687785148621,
0.3553425967693329,
0.8027004599571228,
-0.05097826197743416,
-0.44834762811660767,
-1.2960231304168701,
0.040959183126688004,
0.04667304828763008,
-0.8824340105056763,
0.2323571741580963,
0.4588809907436371,
-0.6558164358139038,
0.06265515834093094,
-0.20162899792194366,
-0.3231302499771118,
-0.04632314667105675,
0.45976725220680237,
-0.13982701301574707,
0.33941954374313354,
-0.05137094855308533,
0.9054234027862549,
-0.0824231281876564,
0.0318966768682003,
0.1794823855161667,
-0.4830458462238312,
0.6123067140579224,
0.25391319394111633,
-0.9150648713111877,
0.5372276902198792,
0.5031220316886902,
-0.949124813079834,
-0.21120277047157288,
0.45005908608436584,
0.33220067620277405,
-0.6184957027435303,
-0.7455804347991943,
0.1402186006307602,
-0.08951395004987717,
-0.7101737856864929,
0.07581281661987305,
0.7994107604026794,
0.20122770965099335,
-0.17926493287086487,
-0.34097594022750854,
0.12410122901201248,
0.38192999362945557,
0.4457962214946747,
0.2092699259519577,
0.15999186038970947,
0.1213446706533432,
-0.2176266461610794,
-0.4022461771965027,
-0.11605072766542435,
0.16357846558094025,
0.4185026288032532,
-0.05208076164126396,
-0.12124752253293991,
0.23257090151309967,
0.5837628245353699,
-0.07192319631576538,
-0.06579024344682693,
-0.43572738766670227,
0.37440305948257446,
0.18020573258399963,
-0.7057267427444458,
0.17123287916183472,
-0.5283708572387695,
-0.7264127135276794,
0.02038458175957203,
-0.2878374755382538,
0.012272443622350693,
0.2035963237285614,
-0.15237736701965332,
-0.1718176007270813,
0.13852889835834503,
-0.18954439461231232,
-0.12828439474105835,
-0.137262761592865,
-0.20188584923744202,
0.2793700397014618,
-0.22297720611095428,
0.15669390559196472,
0.1853356510400772,
-0.2678941786289215,
-0.10798878967761993,
0.044957224279642105,
0.6747363209724426,
0.6290554404258728,
-0.014515526592731476,
-0.025482989847660065,
-0.298387736082077,
-0.04280417412519455,
0.07711970806121826,
0.16812162101268768,
0.5347846150398254,
-0.36820855736732483,
-0.24686791002750397,
0.11263832449913025,
0.17027565836906433,
0.7271397113800049,
0.08461690694093704,
-0.5158736705780029,
0.04098161682486534,
0.33797651529312134,
-0.5870135426521301,
0.4119189977645874,
0.3266812562942505,
0.085335873067379,
-0.6288177371025085,
-0.18589839339256287,
-0.2014189064502716,
-0.467131644487381,
-0.4846622049808502,
-0.29052552580833435,
0.022343777120113373,
0.28686073422431946,
-0.5228810906410217,
0.12350305914878845,
0.04492557421326637,
-0.13094808161258698,
-0.29806700348854065,
0.3580171465873718,
-0.02671199105679989,
0.08644101023674011,
0.2837965190410614,
-0.060435280203819275,
-0.3845873475074768,
0.1517365276813507,
0.7343838810920715,
-0.7331893444061279,
-0.1287941038608551,
0.1630934625864029,
-0.20705528557300568,
-0.18967387080192566,
0.389509379863739,
-0.029857192188501358,
-0.5091336369514465,
-0.10283107310533524,
-0.050508204847574234,
-0.14788126945495605,
0.2732594907283783,
0.7209596633911133,
0.22756044566631317,
0.28502708673477173,
-0.3102819621562958,
-0.16422797739505768,
-0.012789854779839516,
0.23094451427459717,
0.11706303805112839,
-0.4785826504230499,
-0.3930533230304718,
-0.12628315389156342,
0.5383751392364502,
-0.5099413394927979,
0.04830821976065636,
0.2816512882709503,
0.8841218948364258,
0.2811299264431,
-0.3714507222175598,
-0.13798342645168304,
-0.06433751434087753,
0.2019302099943161,
-0.0818963423371315,
-0.6335114240646362,
-0.2774238884449005,
-0.057731788605451584,
0.47120100259780884,
-0.22381989657878876,
-0.17071597278118134,
-0.5002460479736328,
0.18768088519573212,
-0.24236056208610535,
0.16117174923419952,
-0.04364679753780365,
0.8698620796203613,
0.6830277442932129,
-0.20694918930530548,
0.28035926818847656,
-0.5447832942008972,
0.43448901176452637,
-0.08968321979045868,
0.131766676902771,
-0.9840923547744751,
-0.4450822174549103,
0.4015950858592987,
-0.30603185296058655,
0.2536037564277649,
-0.5445734262466431,
0.3579109311103821,
-0.19160202145576477,
-0.03312113136053085,
-0.5928553342819214,
0.12179553508758545,
-0.19095571339130402,
-0.6949790120124817,
-0.27505141496658325,
0.24778445065021515,
0.04536880925297737,
0.08687851577997208,
0.2708720564842224,
0.41893690824508667,
-0.14838723838329315,
-0.8660902380943298,
0.5998080372810364,
0.6131353974342346,
-0.6307240724563599,
0.23766757547855377,
0.18170054256916046,
0.25809136033058167,
0.3755219280719757,
-0.5096511244773865,
-0.23877738416194916,
-0.21926671266555786,
-0.10625673085451126,
0.07388029992580414,
-0.2197139710187912,
-0.6472283005714417,
-0.30973389744758606,
-0.5609819293022156,
-0.6919081807136536,
0.7307150959968567,
0.09714224189519882,
0.436654657125473,
0.9591315984725952,
0.6860669255256653,
0.38574814796447754,
-0.44049742817878723,
0.4793272912502289,
0.276388555765152,
0.3973994851112366,
-0.3178694546222687,
0.3203989863395691,
0.456952303647995,
0.5323148369789124,
-0.16830086708068848,
0.2788832485675812,
0.13370031118392944,
0.35828307271003723,
0.041774436831474304,
-0.5254326462745667,
-0.1380586475133896,
0.45707207918167114,
0.6183065176010132,
0.4266957640647888,
-0.006271615158766508,
-0.022628506645560265,
0.13733795285224915,
0.4622073173522949,
0.08316925913095474,
0.31633779406547546,
-0.08220040053129196,
0.31716376543045044,
-0.3511459231376648,
-0.41359567642211914,
-0.36813884973526,
0.004520196933299303,
-0.5065075159072876,
0.18329089879989624,
0.45609110593795776,
-0.3172956109046936,
-1.0641121864318848,
-0.09872911125421524,
-0.5019028782844543,
0.1516817957162857,
-0.18228785693645477,
0.7038437724113464,
-0.3794557452201843,
-0.025931334123015404,
0.30178335309028625,
0.31215396523475647,
0.46390408277511597,
-0.6515969634056091,
0.3043005168437958,
-0.22434045374393463,
-0.41640952229499817,
0.44821619987487793,
-0.01976899243891239,
-0.3574807643890381,
-0.1300525814294815,
-0.03320833295583725,
-0.13496261835098267,
0.18418751657009125,
-0.2962764799594879,
0.07102319598197937,
0.3564163148403168,
-0.6556549072265625,
-0.14695362746715546,
-0.3155405819416046,
-0.3764670193195343,
0.11678441613912582,
0.35844507813453674,
-0.05056753754615784,
0.3729567527770996,
-0.9423564672470093,
0.6212531924247742,
0.34018033742904663,
-0.5189114212989807,
-0.1119106188416481,
0.09696415811777115,
0.343172162771225,
0.4388161301612854,
0.3511772155761719,
-0.043458033353090286,
0.3272480070590973,
0.00439213402569294,
0.7718325257301331,
-0.5852094888687134,
0.5216187834739685,
-0.5104171633720398,
-0.6278151273727417,
-0.5778494477272034,
-0.010882397182285786,
0.8499660491943359,
0.304299920797348,
-0.2677554786205292,
-0.1516260802745819,
0.30374181270599365,
0.28201040625572205,
0.23540495336055756,
-0.17371611297130585,
-0.00004191906555206515,
-0.2922310531139374,
-0.020745916292071342,
-0.6634013056755066,
0.43896403908729553,
-0.1467694342136383,
-0.46170052886009216,
-0.058655738830566406,
0.42096447944641113,
0.5172761082649231,
-0.06018160283565521,
0.25382301211357117,
-0.5207242369651794,
-0.18124142289161682,
-0.6922595500946045,
0.4171801209449768,
-0.2394995540380478,
0.6976984143257141,
-0.2395542562007904,
0.4550248682498932,
0.23601403832435608,
-0.3162860572338104,
-0.10112028568983078,
-0.29165053367614746,
0.17358079552650452,
-0.04606788605451584,
-0.12035541236400604,
0.6330806016921997,
0.2760136127471924,
-0.34071505069732666,
-1.148234248161316,
0.15680991113185883,
-0.28363117575645447,
-1.0731160640716553,
-0.2297891229391098,
0.2807804048061371,
-0.555860161781311,
-0.3286084234714508,
0.25368353724479675,
-0.4296734035015106,
-0.37989872694015503,
-0.29872021079063416
] |
Pfam is a widely used database of protein families, currently containing more than 13,000 manually curated protein families as of release 26.0. Pfam is available via servers in the UK (http://pfam.sanger.ac.uk/), the USA (http://pfam.janelia.org/) and Sweden (http://pfam.sbc.su.se/). Here, we report on changes that have occurred since our 2010 NAR paper (release 24.0). Over the last 2 years, we have generated 1840 new families and increased coverage of the UniProt Knowledgebase (UniProtKB) to nearly 80%. Notably, we have taken the step of opening up the annotation of our families to the Wikipedia community, by linking Pfam families to relevant Wikipedia pages and encouraging the Pfam and Wikipedia communities to improve and expand those pages. We continue to improve the Pfam website and add new visualizations, such as the 'sunburst' representation of taxonomic distribution of families. In this work we additionally address two topics that will be of particular interest to the Pfam community. First, we explain the definition and use of family-specific, manually curated gathering thresholds. Second, we discuss some of the features of domains of unknown function (also known as DUFs), which constitute a rapidly growing class of families within Pfam. | [
0.009307397529482841,
0.0064324745908379555,
0.002392697613686323,
0.017744533717632294,
-0.0014347309479489923,
-0.010769994929432869,
0.005176118109375238,
0.01934804767370224,
-0.010049385949969292,
0.0030881690327078104,
-0.0020099200773984194,
0.0053368848748505116,
0.009846859611570835,
0.006962085608392954,
0.005392455495893955,
0.017901279032230377,
-0.02023932710289955,
-0.005747130606323481,
0.008379785344004631,
0.0005301570054143667,
0.022774463519454002,
0.0037590886931866407,
0.005749628879129887,
-0.005054785870015621,
0.003169179428368807,
0.005275656469166279,
0.01303496491163969,
-0.011343372985720634,
-0.0047401380725204945,
-0.006941795349121094,
0.013735400512814522,
-0.013112127780914307,
-0.004109169822186232,
-0.0015009285416454077,
-0.001954018836840987,
0.0010791178792715073,
-0.007171697914600372,
0.0089217284694314,
-0.0009276601485908031,
-0.003528634551912546,
-0.005014348775148392,
-0.005941292736679316,
0.0034944689832627773,
-0.0016788971843197942,
-0.004205605015158653,
0.02369309961795807,
-0.012634770944714546,
0.01900985836982727,
-0.025108281522989273,
0.009763844311237335,
-0.010476157069206238,
-0.00600234791636467,
-0.008453987538814545,
-0.012629140168428421,
-0.003554267343133688,
-0.01185888983309269,
0.0138810183852911,
-0.019477996975183487,
0.008958469144999981,
-0.013618908822536469,
0.01228967122733593,
-0.012061896733939648,
0.016971435397863388,
0.022027166560292244,
-0.01873570866882801,
-0.06854787468910217,
0.010602612979710102,
-0.018757963553071022,
-0.003640707116574049,
-0.006547235883772373,
0.022962575778365135,
0.011902110651135445,
-0.0018030088394880295,
0.00211179512552917,
-0.005180949345231056,
-0.018144352361559868,
0.0011899573728442192,
0.02669205702841282,
0.0005131646757945418,
-0.006896953098475933,
-0.020816320553421974,
-0.012248203158378601,
0.016950979828834534,
0.0015438396949321032,
-0.0062019662000238895,
0.004783467389643192,
-0.02360241860151291,
0.012164483778178692,
0.002335670869797468,
-0.0044507128186523914,
0.010798740200698376,
0.008396109566092491,
0.009134050458669662,
0.0097613874822855,
0.02628249302506447,
0.00799438264220953,
-0.007864962331950665,
-0.010974082164466381,
-0.0034307700116187334,
-0.004049715586006641,
0.0030480315908789635,
-0.009397008456289768,
0.008426010608673096,
-0.013357030227780342,
0.01607118360698223,
0.010925444774329662,
0.0015629942063242197,
-0.012719581834971905,
0.010815536603331566,
-0.0006476755952462554,
0.010410841554403305,
-0.007999647408723831,
-0.01993069425225258,
-0.008606858551502228,
-0.02745790034532547,
0.00019389053341001272,
-0.003378435969352722,
0.0033472864888608456,
0.005463958717882633,
0.012766028754413128,
0.00399359967559576,
0.007298578508198261,
0.004578899126499891,
0.024286722764372826,
0.0063673024997115135,
0.0011669702362269163,
0.01931028813123703,
-0.004727631341665983,
0.022399647161364555,
-0.004097505006939173,
-0.00434817373752594,
0.00035628117620944977,
-0.0006634132005274296,
0.004932028241455555,
0.008082900196313858,
0.0006224476965144277,
0.001393694430589676,
0.004938731901347637,
-0.016832511872053146,
-0.017904197797179222,
-0.0033654943108558655,
0.01003190502524376,
0.008928222581744194,
0.009576365351676941,
0.005173038691282272,
-0.0054065459407866,
-0.009957350790500641,
-0.0003884399775415659,
-0.013587161898612976,
0.0005828296998515725,
-0.0022434797137975693,
0.0016779005527496338,
-0.015262135304510593,
-0.015531135722994804,
-0.0029152457136660814,
-0.007729503326117992,
0.002593129640445113,
-0.01258939690887928,
0.006487772334367037,
-0.004220699891448021,
0.003390049561858177,
0.009377698414027691,
0.01718773879110813,
0.005358061287552118,
0.01059909351170063,
-0.011402694508433342,
0.018156662583351135,
-0.01216597855091095,
-0.007371612824499607,
0.0021877337712794542,
0.00017769253463484347,
0.013291440904140472,
0.009051971137523651,
0.0017607691697776318,
-0.0012939493171870708,
-0.0074861119501292706,
-0.01619436964392662,
0.0032582294661551714,
-0.009875021874904633,
0.06793032586574554,
-0.015407602302730083,
0.01864556409418583,
-0.01413927972316742,
-0.006395099684596062,
0.0039156354032456875,
-0.004989280831068754,
0.026645194739103317,
-0.013084563426673412,
0.0011529901530593634,
0.006242471747100353,
-0.011976614594459534,
-0.006696274504065514,
-0.03078523837029934,
0.013463057577610016,
0.009674117900431156,
0.002860373817384243,
-0.0073364609852433205,
0.005834316834807396,
-0.009851546958088875,
-0.024808913469314575,
0.0038368951063603163,
-0.004810621030628681,
-0.005550953093916178,
-0.0091684740036726,
0.009779760614037514,
0.018806103616952896,
0.0025026577059179544,
-0.01096498966217041,
0.021811433136463165,
-0.009826421737670898,
0.0020338192116469145,
-0.02189430221915245,
-0.0004806725773960352,
-0.016551857814192772,
0.0032963561825454235,
-0.006247375626116991,
-0.009839731268584728,
-0.002364726271480322,
0.02612881362438202,
-0.009610788896679878,
-0.006425041705369949,
0.005797128193080425,
-0.015708724036812782,
-0.008114536292850971,
0.006519858725368977,
0.026999425143003464,
0.010490916669368744,
0.00465644896030426,
-0.0010025885421782732,
0.00952984020113945,
0.006579847075045109,
-0.00044173537753522396,
-0.008522557094693184,
0.004678633064031601,
-0.012705503031611443,
-0.0010375392157584429,
0.006841786205768585,
-0.015269150957465172,
-0.0019732818473130465,
-0.00881576631218195,
0.005191362928599119,
-0.008738239295780659,
0.017622197046875954,
-0.024417798966169357,
0.0006921864114701748,
-0.015880491584539413,
0.014890293590724468,
-0.01263333112001419,
-0.0263944324105978,
-0.006824484560638666,
0.003907821141183376,
0.010009892284870148,
0.017052002251148224,
-0.012590089812874794,
0.011653912253677845,
-0.003506502602249384,
0.012502754107117653,
-0.03279803693294525,
0.019410641863942146,
0.00632880674675107,
0.006475674454122782,
0.005855067633092403,
-0.010338387452065945,
-0.01792539469897747,
-0.013112668879330158,
0.0033019371330738068,
-0.003120147157460451,
0.0031801334116607904,
0.003028108738362789,
-0.027400635182857513,
0.0023430949077010155,
-0.009307017549872398,
0.0004476515459828079,
-0.08236053586006165,
-0.002486321609467268,
0.002312049735337496,
-0.016645284369587898,
0.00858522392809391,
0.0332501046359539,
-0.018954142928123474,
-0.003888861509039998,
-0.010447888635098934,
-0.000014394288882613182,
0.005967180710285902,
0.003734217956662178,
-0.007152661681175232,
0.015450606122612953,
0.02680082619190216,
-0.0008856195490807295,
0.008020643144845963,
0.020400455221533775,
0.00813344493508339,
-0.00940096564590931,
-0.02023530751466751,
0.0048558092676103115,
0.022305205464363098,
-0.006259846966713667,
-0.027684690430760384,
0.013229704461991787,
-0.00045348238199949265,
0.0042678434401750565,
0.0009501083986833692,
-0.00535882543772459,
-0.014946488663554192,
-0.014041850343346596,
-0.004869756288826466,
-0.016611425206065178,
0.009122191928327084,
-0.006122945807874203,
-0.0010967011330649257,
-0.00774390809237957,
-0.012769664637744427,
-0.0013767709024250507,
-0.013556655496358871,
0.007177521474659443,
0.002895115874707699,
-0.007365793455392122,
-0.010526349768042564,
0.003654886968433857,
-0.02158142253756523,
-0.010166166350245476,
0.008611941710114479,
-0.009033551439642906,
0.006408019457012415,
-0.007532193791121244,
0.016653895378112793,
0.013283914886415005,
-0.006138807162642479,
0.015417453832924366,
0.028033031150698662,
0.025204725563526154,
-0.00914030335843563,
-0.004220846574753523,
-0.035428356379270554,
-0.0038863413501530886,
0.0028004739433526993,
0.006544966716319323,
0.0020853658206760883,
0.005535283125936985,
0.0022347797639667988,
-0.02209857851266861,
0.013788970187306404,
0.008406388573348522,
0.003649333491921425,
-0.0003262533573433757,
-0.014951363205909729,
0.004047159105539322,
0.008884763345122337,
-0.01116214506328106,
-0.01449564564973116,
-0.007087600417435169,
0.008955655619502068,
0.002869535004720092,
-0.004661025013774633,
-0.0027817878872156143,
0.006660154089331627,
0.004324318841099739,
-0.008274535648524761,
-0.01044442132115364,
0.012563249096274376,
0.0013300065184012055,
0.0002583738532848656,
-0.005976979620754719,
0.038514912128448486,
0.020401153713464737,
0.014197197742760181,
0.0010373325785622,
-0.006134374998509884,
0.0059309424832463264,
0.0152768325060606,
-0.0027856691740453243,
-0.005852658301591873,
0.005311301909387112,
0.005267675034701824,
-0.009211057797074318,
0.009927146136760712,
-0.011734403669834137,
-0.025258567184209824,
0.009003698825836182,
-0.010104816406965256,
0.021677671000361443,
-0.011023495346307755,
-0.000803646631538868,
-0.008402060717344284,
0.005947801750153303,
-0.009699344635009766,
0.004508767277002335,
0.007846713997423649,
-0.015099292621016502,
-0.00236997427418828,
0.002576705999672413,
0.07415959239006042,
0.01616092585027218,
-0.003747901413589716,
-0.012902820482850075,
0.00962328352034092,
-0.019353501498699188,
0.002201181137934327,
-0.007001036312431097,
0.02355325222015381,
-0.023242704570293427,
0.007967603392899036,
0.0035175131633877754,
0.011279281228780746,
-0.01009167917072773,
-0.021356727927923203,
0.009306173771619797,
-0.012014692649245262,
0.0023939257953315973,
-0.0028224317356944084,
-0.016272451728582382,
0.0012531892862170935,
-0.014744425192475319,
-0.0017487718723714352,
-0.00089719780953601,
-0.016391845420002937,
-0.02264406345784664,
0.021332764998078346,
-0.012472480535507202,
0.0007334291003644466,
0.0031923879869282246,
0.013489171862602234,
0.02201695740222931,
-0.007765334099531174,
-0.003888003760948777,
0.00847040768712759,
0.00625608442351222,
0.0031773452647030354,
0.00012105563655495644,
-0.009807130321860313,
-0.015138913877308369,
-0.017296401783823967,
-0.010840965434908867,
-0.01776162162423134,
-0.0025891587138175964,
-0.020676111802458763,
0.0030634254217147827,
0.0007375448476523161,
-0.007468735799193382,
-0.013591542840003967,
-0.005132127553224564,
-0.004461450502276421,
0.010927965864539146,
0.007110267877578735,
0.003372829407453537,
0.024855146184563637,
-0.0028617996722459793,
-0.00672701932489872,
-0.0002738761540967971,
0.0007783828768879175,
0.009750531055033207,
-0.01709316298365593,
0.014098281040787697,
0.0011866946006193757,
-0.005040010437369347,
-0.0027005216106772423,
-0.004577497020363808,
0.0017484044656157494,
-0.010082954540848732,
0.005328994244337082,
-0.005211931187659502,
0.01089982409030199,
-0.010023431852459908,
0.009214349091053009,
-0.013013027608394623,
0.002187262987717986,
0.0018084323965013027,
-0.023970847949385643,
-0.011652925983071327,
-0.018422041088342667,
-0.008064412511885166,
0.019716979935765266,
0.010083417408168316,
-0.014482871629297733,
-0.0029661061707884073,
0.001784752239473164,
-0.014606448821723461,
0.021719232201576233,
-0.0753464475274086,
0.006916159763932228,
0.015274353325366974,
0.0031695039942860603,
-0.003505558241158724,
0.008461285382509232,
0.0032028176356106997,
-0.008130785077810287,
0.0026925711426883936,
-0.009496083483099937,
-0.006292018573731184,
0.00229602656327188,
0.018830930814146996,
0.0035607567988336086,
0.007817216217517853,
0.007398045621812344,
0.013466566801071167,
0.007331899367272854,
-0.016482841223478317,
-0.01126050390303135,
0.0073662507347762585,
0.03360695764422417,
0.012803182937204838,
0.006651250645518303,
-0.016055602580308914,
-0.08291275799274445,
0.004838913679122925,
0.013510891236364841,
-0.024020973592996597,
-0.0035560992546379566,
-0.013748925179243088,
0.01136997900903225,
-0.00874221883714199,
-0.024533355608582497,
-0.009705053642392159,
-0.010769033804535866,
-0.018052689731121063,
0.00017829053103923798,
0.0034353798255324364,
-0.006355377845466137,
-0.003075861372053623,
0.006835822947323322,
0.010687340050935745,
0.004110930487513542,
0.00015340454410761595,
-0.01514796819537878,
0.0163682010024786,
-0.0017189907375723124,
-0.007047870196402073,
-0.0018270888831466436,
0.013264498673379421,
-0.005586643703281879,
0.00940839946269989,
0.005399232264608145,
-0.006569836288690567,
0.013897151686251163,
0.0071200039237737656,
-0.005252537317574024,
-0.026084832847118378,
-0.0014527813764289021,
-0.009454513899981976,
0.007032414432615042,
-0.008626043796539307,
0.012165536172688007,
-0.006875222083181143,
-0.004347584210336208,
0.03585977852344513,
0.01140529103577137,
-0.0011023393599316478,
0.013764714822173119,
-0.029439877718687057,
0.008494858630001545,
-0.006295982748270035,
0.008391614072024822,
-0.0005685510113835335,
0.01157422550022602,
-0.014138666912913322,
0.011077349074184895,
0.0057145762257277966,
0.009881268255412579,
-0.0038815983571112156,
-0.003419396933168173,
-0.0019403775222599506,
0.009683261625468731,
0.019015269353985786,
-0.008497646078467369,
-0.001151639618910849,
0.0032211346551775932,
0.07325931638479233,
-0.016760092228651047,
0.002855747239664197,
0.0008728991379030049,
0.01633944734930992,
0.0034846924245357513,
-0.002131291199475527,
0.0059457262977957726,
0.0022016135044395924,
-0.007539266720414162,
-0.006070579867810011,
0.0005293278954923153,
0.011766131967306137,
0.0077688670717179775,
-0.004997776821255684,
-0.005456301849335432,
0.0017102030105888844,
0.002400549128651619,
-0.01432827953249216,
-0.016654618084430695,
-0.018317319452762604,
0.022814063355326653,
-0.012519494630396366,
-0.01297159306704998,
0.011591820046305656,
-0.012436515651643276,
0.026765134185552597,
0.013668936677277088,
0.001784891588613391,
0.0026330878026783466,
-0.005980425514280796,
-0.0002639078302308917,
0.006485600024461746,
0.007897649891674519,
0.003170923562720418,
-0.005077776964753866,
0.0075853243470191956,
0.006678011268377304,
0.01727169007062912,
0.0031542947981506586,
0.013587836176156998,
-0.012323313392698765,
0.004187507554888725,
-0.000720827141776681,
0.017477620393037796,
-0.011697826907038689,
0.0062331547960639,
0.017164472490549088,
0.010612353682518005,
0.0055697327479720116,
-0.012574268504977226,
0.005220536142587662,
-0.0041956729255616665,
0.0001838708994910121,
-0.008257342502474785,
-0.014358392916619778,
-0.009491653181612492,
0.005057228729128838,
-0.005186800379306078,
-0.02073441445827484,
0.023585986346006393,
0.009474445134401321,
0.030636712908744812,
0.011635947972536087,
0.006220001727342606,
-0.017363108694553375,
-0.009406785480678082,
-0.008977686055004597,
0.005237797275185585,
0.00841790996491909,
-0.004253299441188574,
0.007387940771877766,
0.002142799086868763,
0.004431591369211674,
-0.014335861429572105,
0.02421846240758896,
-0.014346791431307793,
0.004355396144092083,
0.0028743366710841656,
-0.006738561205565929,
-0.01419109757989645,
-0.0047694179229438305,
0.004199685994535685,
-0.01875244826078415,
-0.01876138336956501,
0.004998841322958469,
-0.000761058647185564,
-0.014596627093851566,
-0.0033161353785544634,
0.0006614925805479288,
0.014955902472138405,
0.003303688485175371,
0.009931149892508984,
0.0020567600149661303,
0.008667215704917908,
0.03233450651168823,
0.010545874945819378,
0.010541623458266258,
0.0004799256566911936,
0.005044883117079735,
0.004613677505403757,
-0.02004043012857437,
-0.0008410528535023332,
-0.006524478085339069,
0.0066407849080860615,
0.0037755193188786507,
0.012012750841677189,
-0.02551748789846897,
0.030904697254300117,
-0.004189642146229744,
-0.001708354102447629,
0.023434679955244064,
0.011829131282866001,
0.007907658815383911,
-0.003863772377371788,
0.024506468325853348,
0.006498563103377819,
0.019876617938280106,
-0.005404800176620483,
-0.010697809979319572,
0.0009201467037200928,
-0.021740078926086426,
-0.011847492307424545,
-0.0015654932940378785,
-0.0053133429028093815,
0.010010283440351486,
0.002003935631364584,
0.007454537320882082,
-0.017341773957014084,
0.009688408114016056,
0.016725052148103714,
-0.016544168815016747,
0.0034349767956882715,
0.02432948909699917,
-0.008429533801972866,
-0.005846924148499966,
0.01004292443394661,
-0.002855023369193077,
0.01518328208476305,
-0.029270922765135765,
0.00855625607073307,
0.007632569409906864,
0.018721120432019234,
0.005878979805856943,
0.007019714917987585,
0.002063840627670288,
0.014358580112457275,
-0.0029183141887187958,
0.00097904191352427,
0.004149853717535734,
0.011872870847582817,
-0.007798959035426378,
-0.0032938646618276834,
-0.0015395762166008353,
0.001764356391504407,
0.0023588528856635094,
0.002959128003567457,
0.004896765574812889,
0.006222998723387718,
-0.0019006775692105293,
-0.01223200187087059,
0.013059373013675213,
-0.016973230987787247,
0.005289663560688496,
-0.0022492760326713324,
-0.01153253298252821,
0.01908348873257637,
0.0025464966893196106,
-0.003165261819958687,
0.008646332658827305,
-0.016977963969111443,
-0.01330698560923338,
0.002668496686965227,
0.013350190594792366,
0.0015169845428317785,
-0.0037393574602901936,
-0.004355612676590681,
0.01542527787387371,
0.004779572132974863,
0.017402958124876022,
0.001489731715992093,
0.018262691795825958,
0.0017248864751309156,
-0.0077907610684633255,
-0.013006742112338543,
-0.014331471174955368,
-0.009726348333060741,
-0.0061998916789889336,
-0.007616202346980572,
-0.0013339912984520197,
-0.012670330703258514,
-0.003072742372751236,
-0.019612953066825867,
0.00511682964861393,
-0.005262034013867378,
0.0017468129517510533,
-0.011268703266978264,
-0.01736508682370186,
0.006802980322390795,
-0.003163849236443639,
-0.015654131770133972,
-0.00996102299541235
] | [
0.060427237302064896,
0.04699745774269104,
0.5592404007911682,
-0.3071463406085968,
0.03699140250682831,
-0.09017986804246902,
-0.1621210128068924,
-0.27053800225257874,
-0.5883168578147888,
-0.33500587940216064,
-0.49465662240982056,
-0.4748018682003021,
-0.5251736640930176,
0.5655562281608582,
-0.1237681433558464,
0.5520630478858948,
0.27083155512809753,
0.5467045903205872,
0.03348030149936676,
-0.0237139780074358,
-0.31294915080070496,
-0.07883580029010773,
0.6221367120742798,
-0.27842897176742554,
-0.1708170622587204,
0.07555492967367172,
0.6006315350532532,
0.1575387567281723,
0.08277517557144165,
0.35987383127212524,
-0.2151769995689392,
0.23326939344406128,
0.27216213941574097,
-0.24870392680168152,
-0.25245893001556396,
-0.14472778141498566,
-0.12203384190797806,
0.1902020126581192,
0.1749122142791748,
-0.5059852600097656,
-0.6927496790885925,
-0.24679119884967804,
-0.4423908591270447,
0.7578177452087402,
-0.34085613489151,
-0.17617714405059814,
-1.1423684358596802,
0.44768860936164856,
-0.33561480045318604,
-0.08923512697219849,
-0.5142115354537964,
-0.03101462870836258,
0.33374619483947754,
0.05495547875761986,
0.2065332680940628,
-0.0975482314825058,
-0.7117131352424622,
0.0010771435918286443,
-0.027049798518419266,
-0.0632539913058281,
0.5936536192893982,
-0.18548715114593506,
0.5308798551559448,
0.17663326859474182,
0.22101479768753052,
0.2548474073410034,
0.0289829820394516,
-0.45947423577308655,
-0.44002479314804077,
0.0815354660153389,
0.4413865804672241,
-0.5656418204307556,
-0.6078972816467285,
-0.11928164958953857,
0.03452160954475403,
0.012633956037461758,
-0.4356236755847931,
0.00486707454547286,
0.6446318626403809,
0.03827008977532387,
0.03748328611254692,
-0.030142370611429214,
0.31705862283706665,
0.10306046158075333,
0.529471755027771,
0.14770880341529846,
-0.23241503536701202,
0.05904411897063255,
-0.24514703452587128,
0.3058905601501465,
0.2778092324733734,
-0.28477802872657776,
0.5524323582649231,
0.4574120342731476,
0.5330742001533508,
-0.4406852722167969,
-0.176792174577713,
-0.19624973833560944,
-0.19048404693603516,
0.2684362530708313,
-0.0020554927177727222,
0.2250775843858719,
-0.10406310856342316,
-0.969199538230896,
-0.3132063150405884,
-0.4605261981487274,
-0.01875391975045204,
-0.8676796555519104,
0.1817401647567749,
-0.3361445367336273,
-0.3481077551841736,
0.00734051363542676,
-0.09399832785129547,
-0.36129230260849,
-0.5094025731086731,
0.4002864360809326,
0.2286268174648285,
-0.5997806787490845,
0.6121631264686584,
0.4043208062648773,
0.01930743269622326,
1.0747486352920532,
0.44139233231544495,
0.2267446368932724,
0.08253851532936096,
0.22766809165477753,
0.5639659762382507,
0.17759953439235687,
-0.3433905243873596,
0.6226058006286621,
0.009245239198207855,
0.5411286950111389,
0.18366776406764984,
0.29144930839538574,
0.3763488233089447,
-0.32009953260421753,
-0.061034154146909714,
0.12206253409385681,
0.42151352763175964,
0.01668192818760872,
-0.4468548893928528,
-0.45873525738716125,
-0.4613037705421448,
-0.22357377409934998,
0.22591544687747955,
-0.0508904829621315,
-0.479056715965271,
-0.6832250952720642,
-0.5611856579780579,
-0.20162002742290497,
-0.26815494894981384,
-0.25664013624191284,
-0.5768691897392273,
-0.012762179598212242,
-0.08454558253288269,
0.42892614006996155,
-0.010107871145009995,
-0.043767303228378296,
-0.014506658539175987,
0.19061051309108734,
0.712161123752594,
0.07031655311584473,
-0.4776129126548767,
-0.20322203636169434,
0.6186677813529968,
-0.061599623411893845,
0.49879372119903564,
0.5761394500732422,
-0.11172322928905487,
0.21385827660560608,
-0.21431191265583038,
-0.11987738311290741,
0.38597288727760315,
-0.3377245366573334,
-0.3419687747955322,
0.178750678896904,
0.9034706354141235,
-0.5038743615150452,
0.04084243252873421,
0.09891248494386673,
-0.5609613060951233,
-0.23203979432582855,
0.3477214276790619,
-0.4042778015136719,
0.3495247960090637,
0.2532305121421814,
0.5178551077842712,
0.19896261394023895,
0.45090487599372864,
0.42761725187301636,
-0.19377848505973816,
-0.25836625695228577,
0.5548291206359863,
-0.45807692408561707,
1.0779802799224854,
-0.13181814551353455,
0.11407242715358734,
1.1404094696044922,
-0.0868128091096878,
-0.04361102730035782,
-0.34302374720573425,
0.32276374101638794,
0.201308473944664,
-0.3565816283226013,
-0.6300373673439026,
-0.4209243357181549,
-0.46328479051589966,
-0.010429345071315765,
-0.18907871842384338,
-0.39687928557395935,
0.35473567247390747,
-0.5417781472206116,
0.17264966666698456,
0.027722807601094246,
0.05712418258190155,
-0.18100371956825256,
-0.19468826055526733,
0.332453191280365,
-0.17374078929424286,
-0.26410385966300964,
0.9968847036361694,
-0.3474721312522888,
0.08720491081476212,
0.1065359115600586,
-0.5348740220069885,
0.4813414216041565,
0.5222135186195374,
0.4159764051437378,
0.7241010069847107,
0.018034055829048157,
0.8197923302650452,
-0.47963640093803406,
0.4358242452144623,
-0.6877748966217041,
-0.10064023733139038,
0.09788200259208679,
-0.24274088442325592,
0.12397895753383636,
-0.060587916523218155,
-0.2645956575870514,
0.08262749761343002,
0.8703861236572266,
-0.38303810358047485,
-0.7068381309509277,
0.22015638649463654,
-0.5677692890167236,
0.306747168302536,
-0.07439377903938293,
-0.1865505427122116,
0.01106677483767271,
0.1126435324549675,
0.19339174032211304,
0.18039268255233765,
-0.09171079844236374,
-0.3325901925563812,
0.20236846804618835,
0.18533143401145935,
-0.048469118773937225,
-0.3646917939186096,
0.26478081941604614,
-0.16967827081680298,
-0.5394316911697388,
-0.24353964626789093,
0.12959769368171692,
0.061661750078201294,
-0.7977177500724792,
0.15528647601604462,
-0.7484486103057861,
1.0002808570861816,
0.5645041465759277,
0.685893177986145,
-0.0026046622078865767,
-0.3545096218585968,
0.08487904816865921,
0.1942376345396042,
-1.1565446853637695,
0.34394165873527527,
0.01716066524386406,
-0.03208952024579048,
-0.4758264720439911,
-0.11786538362503052,
0.38403773307800293,
1.030142068862915,
-0.2782716453075409,
-0.3065604269504547,
-0.3288692235946655,
0.571205735206604,
0.09190422296524048,
0.25435498356819153,
0.6902320384979248,
-0.00027432243223302066,
0.2785060703754425,
-0.5029680728912354,
-0.8684149980545044,
0.11357210576534271,
0.3762557804584503,
0.10375501215457916,
0.43360933661460876,
-0.13831041753292084,
0.40397515892982483,
-0.8518755435943604,
-0.19433200359344482,
-0.044978540390729904,
-0.6017812490463257,
0.18048803508281708,
0.21097585558891296,
-0.21731334924697876,
-0.014348342083394527,
-5.713047504425049,
-0.09358322620391846,
-0.9573527574539185,
-0.3060825765132904,
-0.20853736996650696,
0.1403314620256424,
0.5170256495475769,
0.042092885822057724,
0.06904882937669754,
-0.2081502079963684,
0.04867008328437805,
0.08611197024583817,
0.18607406318187714,
0.3284129500389099,
0.021097203716635704,
0.5853033661842346,
-0.16860318183898926,
0.296709269285202,
0.5934671759605408,
-0.21094363927841187,
0.0797511637210846,
-0.7130488157272339,
0.1425926387310028,
0.2200634479522705,
0.05333058163523674,
0.510955810546875,
-1.2289578914642334,
0.13486924767494202,
-0.1165456473827362,
-0.2589191794395447,
0.22606398165225983,
-0.6268792152404785,
-0.4407915771007538,
-0.7114223837852478,
-0.23726364970207214,
-0.1503259390592575,
-0.3266475200653076,
0.27882447838783264,
-0.2649213671684265,
0.07018827646970749,
1.0834780931472778,
0.01710372604429722,
-0.10845966637134552,
-0.5497671961784363,
0.004770833533257246,
-0.4600822329521179,
-0.7210776805877686,
0.7209222316741943,
-0.3353113830089569,
0.39868757128715515,
-0.23778972029685974,
-0.244012713432312,
0.5018211603164673,
0.02062252163887024,
-0.24575389921665192,
-0.06634363532066345,
0.43136096000671387,
0.18534216284751892,
-0.26971566677093506,
-0.029789643362164497,
-0.025012558326125145,
-0.21393825113773346,
0.4361470639705658,
-0.6607389450073242,
-0.5267675518989563,
0.2254447042942047,
-1.0781100988388062,
-0.3620167374610901,
0.37234988808631897,
-0.0007357267895713449,
-0.7409670352935791,
-0.11010897904634476,
-0.049236442893743515,
-0.6176063418388367,
0.20042918622493744,
-0.5331791043281555,
0.3261675536632538,
-0.297539621591568,
-0.20215685665607452,
0.12247197329998016,
0.3161706328392029,
-0.20324862003326416,
0.027242140844464302,
-0.18489417433738708,
0.1002873033285141,
-0.9097828269004822,
-0.5585945844650269,
-0.14620071649551392,
-0.2740319073200226,
0.11725448071956635,
0.22253155708312988,
-0.4549093544483185,
0.5566908717155457,
0.14753374457359314,
0.5007435083389282,
-0.17479391396045685,
0.5458436608314514,
0.2032330185174942,
0.4821763336658478,
0.113954097032547,
0.630878746509552,
-0.06335777789354324,
-0.4000636339187622,
-0.941393256187439,
-0.17960193753242493,
0.08705885708332062,
-0.7537904977798462,
0.18176938593387604,
0.7611208558082581,
-0.2296660989522934,
-0.4088132381439209,
-0.2873856723308563,
-0.12717702984809875,
-0.4323345422744751,
0.5253065228462219,
-0.009440531022846699,
-0.2523476183414459,
0.07960686832666397,
-0.03058924525976181,
-0.2887822985649109,
-0.3758644461631775,
0.005717128980904818,
-0.20211899280548096,
0.46934497356414795,
0.18220311403274536,
-0.4730183184146881,
0.4813314378261566,
-0.048412151634693146,
-0.18813252449035645,
-0.48230689764022827,
0.5279219150543213,
0.2615834176540375,
-0.30170759558677673,
-0.21188606321811676,
0.5409347414970398,
0.11782696098089218,
-0.22943377494812012,
0.4909067451953888,
0.2126031219959259,
-0.7748839259147644,
0.4425528645515442,
-0.18153797090053558,
-0.11679183691740036,
0.5667848587036133,
0.40321430563926697,
0.25233152508735657,
0.8144887685775757,
0.9112345576286316,
0.5192521810531616,
0.2539267838001251,
-0.11965037137269974,
-0.15525144338607788,
0.041028041392564774,
0.050746627151966095,
-0.4201539158821106,
0.25762346386909485,
0.5659288763999939,
0.506430983543396,
0.262969970703125,
-0.7629296183586121,
-0.3740605413913727,
-0.22301644086837769,
-0.8369847536087036,
0.10522244870662689,
-0.38814446330070496,
-0.3562247157096863,
0.12007175385951996,
0.39095547795295715,
-0.4345487356185913,
0.1824636459350586,
-0.5115976929664612,
-0.04065539315342903,
0.2725568413734436,
-0.5275871157646179,
-0.054118722677230835,
0.24639971554279327,
0.39768072962760925,
-0.20876161754131317,
-0.08286910504102707,
0.8102902770042419,
-0.048170529305934906,
-0.4347454309463501,
-0.22208942472934723,
0.3499295711517334,
0.12986470758914948,
0.4592038094997406,
-0.036472562700510025,
0.06346004456281662,
0.19502346217632294,
-0.5575029850006104,
-0.22766205668449402,
0.26437512040138245,
0.06534100323915482,
-0.0357336550951004,
-0.017425622791051865,
-0.26631277799606323,
0.48684701323509216,
0.3745024800300598,
0.15978080034255981,
-0.7418709397315979,
0.2805830240249634,
0.7179197669029236,
-0.4168413281440735,
0.44473209977149963,
0.5480108261108398,
-0.33254846930503845,
-0.21436519920825958,
-0.1493685096502304,
0.17320090532302856,
0.10948271304368973,
0.08199704438447952,
-0.14858895540237427,
0.08515729010105133,
0.5075222849845886,
-0.45747023820877075,
0.40987926721572876,
0.2579360902309418,
0.19564615190029144,
-0.18231312930583954,
0.12123137712478638,
-0.19479945302009583,
-0.28117793798446655,
0.238169863820076,
0.05328807234764099,
-0.590825617313385,
0.11016260087490082,
0.3279305398464203,
-0.4690677523612976,
-0.24747566878795624,
-0.22570039331912994,
0.3813411593437195,
-0.0022455663420259953,
0.14950869977474213,
-0.017467863857746124,
-0.15768779814243317,
-0.8137616515159607,
-0.8724924921989441,
-0.06495050340890884,
0.0191174428910017,
0.6106212139129639,
-0.578658401966095,
0.24697205424308777,
-0.005233773496001959,
-0.6223698258399963,
-0.6343525648117065,
-0.28193891048431396,
0.6028444766998291,
-0.5181847810745239,
-0.32445228099823,
0.009676369838416576,
0.06967581063508987,
-0.3355996906757355,
0.08989632874727249,
0.5437442064285278,
1.2396341562271118,
0.7812602519989014,
-0.19799894094467163,
-0.10041037946939468,
-0.09610956907272339,
0.15348319709300995,
-0.15386201441287994,
0.5154606699943542,
-0.502368152141571,
0.0071391211822628975,
0.6068923473358154,
-0.2902714014053345,
-0.2572266459465027,
-0.6538841724395752,
0.2798175811767578,
-0.23913943767547607,
-0.3597397804260254,
0.6595467329025269,
0.1889180988073349,
0.5316276550292969,
0.14638864994049072,
0.12284696847200394,
0.022401349619030952,
-0.3283466398715973,
-0.0036080172285437584,
0.4746866524219513,
-0.6532378196716309,
-0.0915202647447586,
0.7710885405540466,
-0.18932083249092102,
0.2871926724910736,
-0.8933889865875244,
0.23180842399597168,
0.08262357860803604,
0.218849316239357,
-0.09422501921653748,
-0.37913501262664795,
0.28650832176208496,
-0.6160135865211487,
0.026643287390470505,
-0.2479058802127838,
0.24732741713523865,
0.4914025068283081,
0.09000353515148163,
-0.20348703861236572,
0.015674471855163574,
-0.3877713680267334,
0.40467754006385803,
0.6244134306907654,
-0.3606433570384979,
0.18151985108852386,
0.16852571070194244,
0.161689892411232,
0.518246054649353,
-0.49642473459243774,
0.5983812808990479,
0.048057056963443756,
-0.31300437450408936,
0.5394906401634216,
0.285599946975708,
-0.7981082201004028,
0.021085556596517563,
-0.6035614609718323,
-0.35716956853866577,
0.706847608089447,
-0.2526377737522125,
0.3624926805496216,
0.5734804272651672,
0.20203986763954163,
0.1917245239019394,
-1.08209228515625,
0.4179561138153076,
0.12113399803638458,
0.48349735140800476,
-0.06331928074359894,
-0.03276865556836128,
0.5757423639297485,
0.2987654507160187,
0.10615195333957672,
0.21458123624324799,
-0.1745498776435852,
-0.09174684435129166,
-0.26818689703941345,
0.41680192947387695,
-0.41567403078079224,
0.6701669692993164,
0.4042907655239105,
0.3358701169490814,
-0.34162238240242004,
-0.2249121367931366,
0.23341666162014008,
-0.026753652840852737,
-0.3968243896961212,
0.22897706925868988,
0.22379529476165771,
0.3259787857532501,
0.04733119159936905,
-0.0642591118812561,
0.16046978533267975,
-0.12095165252685547,
-0.045365773141384125,
-0.10694588720798492,
0.8427658677101135,
-0.7605428695678711,
0.15287750959396362,
-0.04599183797836304,
-0.14543625712394714,
0.7156742215156555,
-0.2127630114555359,
1.278430461883545,
-0.5304507613182068,
0.27586427330970764,
0.29972192645072937,
-0.21615229547023773,
0.2607625126838684,
-0.11837854981422424,
0.021051689982414246,
0.12390492111444473,
-0.12522442638874054,
0.6352948546409607,
-0.5420583486557007,
-0.14344169199466705,
0.11540498584508896,
-0.14846497774124146,
0.15102902054786682,
0.43051689863204956,
-0.11165958642959595,
-0.07085175067186356,
-0.12354973703622818,
-0.6410834789276123,
0.173294797539711,
-0.6364412307739258,
-0.22388577461242676,
-0.13870230317115784,
0.23062632977962494,
0.0021108516957610846,
0.3555656373500824,
-1.232994794845581,
-0.03801542893052101,
-0.14329466223716736,
-0.1311298906803131,
-0.06853290647268295,
-0.13284221291542053,
0.45009028911590576,
0.5650697350502014,
0.039387885481119156,
-0.2475048005580902,
0.07673004269599915,
0.3078548014163971,
0.6712170839309692,
-0.16779725253582,
-0.015371039509773254,
-0.09127990156412125,
-0.29170820116996765,
-0.2635144591331482,
0.5208783149719238,
0.4887641370296478,
0.5779998898506165,
-0.04666072875261307,
0.24875539541244507,
0.1287969946861267,
-0.02956877090036869,
-0.12632836401462555,
-0.0858108326792717,
0.13788312673568726,
-0.11715647578239441,
0.2528257369995117,
-0.7326365113258362,
0.22491443157196045,
0.11685575544834137,
-0.44059959053993225,
-0.12377171963453293,
0.3620051145553589,
0.3865598738193512,
-0.08366890251636505,
0.6719943284988403,
-0.11023975163698196,
-0.12667803466320038,
-0.20498161017894745,
0.3098022937774658,
-0.45307958126068115,
0.4533492922782898,
-0.060834359377622604,
0.3957357108592987,
-0.2525928020477295,
-0.3151252269744873,
-0.4800781309604645,
0.2388920783996582,
0.11078444123268127,
-0.09432807564735413,
0.4680693447589874,
0.7365356087684631,
0.07386182248592377,
-0.694002091884613,
-1.5873907804489136,
0.35028576850891113,
-0.10283561795949936,
0.32230570912361145,
-0.22886981070041656,
-0.7482867240905762,
0.010156063362956047,
-0.0653051808476448,
-0.06907397508621216,
-0.14785291254520416,
-0.12791754305362701,
0.15519468486309052
] |
INTRODUCTION Patients with symptomatic peripheral artery disease (PAD) exhibit reduced functional capacity and increased mortality due to cardiovascular disease. Although exercise has been a cornerstone for clinical treatment to improve walking capacity in patients with symptomatic PAD, its effects on cardiovascular parameters have been poorly explored. Areas covered: This review examines the role of exercise in improving blood pressure in patients with symptomatic PAD and summarizes the current evidence on the acute (single bout of exercise) and chronic effects of walking and resistance exercise on blood pressure and its determinants. Expert commentary: In patients with symptomatic PAD, exercise promotes acute and chronic reductions in blood pressure. These effects were observed particularly after walking and resistance exercise. Future studies are necessary to investigate the effects of other exercise modalities, especially non-painful exercises, on cardiovascular function in patients with symptomatic PAD. | [
-0.013393012806773186,
0.016408758237957954,
-0.011279008351266384,
0.020611878484487534,
0.006054604891687632,
-0.005258296616375446,
0.011075058951973915,
-0.0019080158090218902,
-0.012019355781376362,
-0.022611718624830246,
-0.005853172857314348,
0.024708501994609833,
-0.009865962900221348,
0.016674622893333435,
0.016199644654989243,
0.004114220850169659,
-0.003362795803695917,
-0.004788318183273077,
0.004808826372027397,
-0.0053806304931640625,
0.0012240242213010788,
0.02430563233792782,
0.011309408582746983,
-0.013012679293751717,
-0.016874179244041443,
0.011022903025150299,
0.060341544449329376,
-0.03662889078259468,
-0.01152591872960329,
0.0030626575462520123,
-0.009375251829624176,
-0.015146109275519848,
-0.014623806811869144,
0.007095674052834511,
-0.00542386993765831,
0.005512341856956482,
-0.0036137173883616924,
0.017025189474225044,
-0.029594924300909042,
-0.0056760115548968315,
-0.014412160962820053,
-0.006439067889004946,
0.0063682785257697105,
-0.011140728369355202,
-0.010306889191269875,
0.027586445212364197,
0.00028072716668248177,
0.005572636611759663,
-0.005269118584692478,
0.012183893471956253,
0.0033745295368134975,
-0.012989368289709091,
-0.004387174267321825,
-0.01908860169351101,
-0.0072347791865468025,
-0.025177210569381714,
0.021703043952584267,
-0.0018823528662323952,
-0.029269732534885406,
0.018054144456982613,
0.0039698276668787,
0.031253620982170105,
-0.018011655658483505,
0.0046951789408922195,
-0.03260038048028946,
-0.06656785309314728,
-0.0014879349619150162,
0.024728652089834213,
-0.01098634209483862,
-0.03460296243429184,
-0.019636711105704308,
0.007343895733356476,
0.010927270166575909,
0.0422038659453392,
0.0016526004765182734,
0.006896417587995529,
-0.009800795465707779,
0.0017173890955746174,
0.02912355586886406,
-0.0077930232509970665,
-0.03318160027265549,
-0.014147198759019375,
-0.016499632969498634,
0.015184860676527023,
-0.014287007972598076,
0.0020831944420933723,
-0.0018331576138734818,
-0.030520673841238022,
0.0035427238326519728,
-0.018682289868593216,
0.0009538782760500908,
0.006726200692355633,
-0.0005593812093138695,
0.012246321886777878,
0.0009449631907045841,
0.02809818461537361,
-0.000009968876838684082,
0.002985515398904681,
0.02705041505396366,
-0.02075710892677307,
-0.015972843393683434,
-0.0458117350935936,
0.028872380033135414,
-0.0406118705868721,
0.017310524359345436,
0.017169449478387833,
-0.015309365466237068,
0.016787759959697723,
0.00972013920545578,
0.01083348412066698,
0.02018938586115837,
0.03955663740634918,
0.02100624516606331,
-0.00010322639718651772,
0.0028863060288131237,
0.01921490952372551,
0.028238140046596527,
0.0029435805045068264,
0.012929248623549938,
0.008569039404392242,
-0.005084440112113953,
0.01508677564561367,
0.000967198982834816,
0.02989710494875908,
-0.005211835727095604,
0.019630633294582367,
0.031114846467971802,
0.006907641887664795,
-0.010536568239331245,
0.010710107162594795,
-0.009323147125542164,
0.0008212803513742983,
-0.008601529523730278,
0.023460742086172104,
0.0021083471365273,
-0.0027080047875642776,
0.007972123101353645,
0.005765532609075308,
-0.013959002681076527,
-0.027813123539090157,
0.0016462979838252068,
0.005817455239593983,
-0.0021998644806444645,
0.012392016127705574,
-0.01504923403263092,
-0.017414454370737076,
0.019104307517409325,
0.005851236172020435,
0.007834810763597488,
0.01295171957463026,
0.01613328792154789,
-0.01687108539044857,
0.005508762318640947,
-0.030378766357898712,
-0.038988709449768066,
0.0026264935731887817,
-0.0066840569488704205,
0.03140435740351677,
-0.0041348980739712715,
0.01574784889817238,
-0.04079557955265045,
-0.015320960432291031,
0.016214681789278984,
0.009986876510083675,
0.00004151160828769207,
0.014527371153235435,
-0.007181210909038782,
-0.024196255952119827,
0.010617848485708237,
0.006687657907605171,
-0.009995304979383945,
0.018471654504537582,
-0.044894710183143616,
0.013745914213359356,
-0.012176040560007095,
0.01159335020929575,
0.0006867143092676997,
0.008906201459467411,
-0.0024584780912846327,
0.06647796928882599,
0.009060592390596867,
0.003600360592827201,
0.008664038963615894,
0.00802704505622387,
-0.008779919706285,
-0.029342668130993843,
0.012645285576581955,
-0.011981476098299026,
0.020605359226465225,
0.003928201273083687,
-0.019235584884881973,
-0.0012858831323683262,
0.018312474712729454,
0.004842397756874561,
-0.01897834613919258,
0.004052841104567051,
0.028155755251646042,
0.004182032775133848,
-0.014725756831467152,
-0.009833896532654762,
0.01662914827466011,
-0.0207644235342741,
0.018797606229782104,
-0.01269855909049511,
0.015547829680144787,
0.01362750492990017,
-0.013275445438921452,
-0.02828281745314598,
-0.013655051589012146,
0.025132061913609505,
0.02596774324774742,
0.007706478238105774,
-0.0037801130674779415,
-0.0008490950567647815,
0.0077716270461678505,
-0.005422767251729965,
-0.007229987997561693,
-0.013881998136639595,
-0.014415639452636242,
-0.01871856302022934,
-0.0000168877886608243,
0.02149391919374466,
-0.009166054427623749,
-0.01971745304763317,
0.011736001819372177,
0.012785735540091991,
-0.008900387212634087,
0.016677148640155792,
0.011043214239180088,
-0.0017659058794379234,
0.014949589967727661,
-0.010404925793409348,
-0.009991057217121124,
0.001022293814457953,
0.0023385784588754177,
0.01595410518348217,
0.012954426929354668,
-0.018462110310792923,
0.019790010526776314,
-0.01754266768693924,
-0.0048116156831383705,
-0.04118633270263672,
0.005818786099553108,
0.01297944039106369,
0.030285736545920372,
0.01020527258515358,
-0.019456833600997925,
-0.0024004781153053045,
0.028087250888347626,
-0.014844564720988274,
0.007164988666772842,
-0.0026845508255064487,
-0.020034242421388626,
-0.0029159290716052055,
0.01900669001042843,
-0.01696934923529625,
0.008320997469127178,
0.008310241624712944,
0.024903329089283943,
-0.025062043219804764,
0.011473683640360832,
0.010743855498731136,
0.011365970596671104,
-0.025318099185824394,
-0.014492704533040524,
0.01846756786108017,
0.009976329281926155,
-0.014845272526144981,
-0.005894116126000881,
-0.04251134395599365,
0.010124615393579006,
-0.007461320608854294,
-0.02140090800821781,
-0.08066082000732422,
-0.017090648412704468,
-0.02083517052233219,
0.01503637246787548,
0.013066309504210949,
0.009950978681445122,
0.02691422402858734,
-0.012781571596860886,
-0.02492746338248253,
0.001923893578350544,
-0.0030561957973986864,
-0.011779751628637314,
0.001527143525891006,
0.0279061421751976,
-0.013503174297511578,
-0.011099573224782944,
-0.0003062529140152037,
0.039767421782016754,
-0.011315090581774712,
-0.024939076974987984,
0.002499801106750965,
0.015929287299513817,
-0.01730451174080372,
0.010978715494275093,
-0.014540383592247963,
-0.011556236073374748,
-0.009195533581078053,
-0.008689713664352894,
0.024137549102306366,
0.017153285443782806,
0.03017832711338997,
-0.015594138763844967,
0.025983894243836403,
-0.017413601279258728,
-0.04315800592303276,
-0.0008041281253099442,
-0.013426370918750763,
-0.016130993142724037,
-0.016879169270396233,
0.01833176612854004,
0.024293813854455948,
0.0008995214011520147,
0.001250112196430564,
0.0028046797960996628,
0.015867602080106735,
-0.0041775815188884735,
0.03379345312714577,
-0.019078955054283142,
0.011615210212767124,
0.011957304552197456,
0.011325953528285027,
-0.0018786578439176083,
0.01637556403875351,
0.015087826177477837,
-0.007377052679657936,
-0.02845773473381996,
0.01804630644619465,
-0.018950719386339188,
-0.013899974524974823,
-0.024800684303045273,
-0.0323779322206974,
0.0005858694203197956,
0.03443795070052147,
-0.01619710586965084,
-0.027038607746362686,
0.003927138168364763,
0.00703196506947279,
-0.025676146149635315,
-0.007196137681603432,
0.01576748676598072,
0.019660010933876038,
-0.01749490574002266,
-0.016687437891960144,
-0.008099937811493874,
0.006957577541470528,
-0.012801054865121841,
-0.02139156684279442,
-0.007567607797682285,
0.023013444617390633,
0.017614997923374176,
-0.012045405805110931,
0.009082769975066185,
-0.013526812195777893,
0.024145742878317833,
-0.029981236904859543,
-0.0034518162719905376,
0.009860118851065636,
0.008473058231174946,
0.00799624715000391,
-0.01614517904818058,
-0.009219064377248287,
0.046148110181093216,
-0.004215370863676071,
0.003707452677190304,
0.005480058491230011,
-0.02681720070540905,
-0.0015469096833840013,
0.004779426380991936,
-0.003991939127445221,
0.011065020225942135,
-0.012158175930380821,
0.010022752918303013,
-0.010587570257484913,
-0.017754629254341125,
-0.030984116718173027,
0.017177581787109375,
0.02855166420340538,
-0.009824193082749844,
-0.0007137663778848946,
-0.01743321120738983,
-0.06475741416215897,
0.008750681765377522,
-0.009443305432796478,
0.014098592102527618,
0.011109638959169388,
0.005514461547136307,
0.0027487343177199364,
-0.00048053450882434845,
0.07187968492507935,
0.01463119126856327,
0.002800918882712722,
-0.0028965799137949944,
0.025907151401042938,
-0.018634852021932602,
-0.022119978442788124,
0.0052373167127370834,
0.030459702014923096,
0.003302378347143531,
0.013143165968358517,
-0.01011157687753439,
0.0034946254454553127,
-0.022311728447675705,
-0.016093328595161438,
0.003673013299703598,
-0.004102434031665325,
0.000009036622941493988,
0.0017081829719245434,
-0.005519394297152758,
0.0075389426201581955,
-0.021362051367759705,
-0.02405841276049614,
0.004836678504943848,
0.002705942839384079,
-0.01394538301974535,
0.028945736587047577,
-0.01470009982585907,
-0.01014222577214241,
0.00461957510560751,
-0.003854062408208847,
0.009226415306329727,
-0.0037082128692418337,
0.0005820551887154579,
-0.016359558328986168,
-0.0036515211686491966,
-0.038987644016742706,
-0.00015586044173687696,
-0.005264885723590851,
-0.005302551668137312,
-0.03272424638271332,
-0.01880592480301857,
-0.013168342411518097,
0.012285117991268635,
-0.016290366649627686,
0.013576784171164036,
0.002756157424300909,
-0.0060734134167432785,
-0.01133978646248579,
0.005102102644741535,
-0.020022248849272728,
0.008875581435859203,
0.014439744874835014,
0.016224514693021774,
0.013030404224991798,
-0.013306722044944763,
-0.021340040490031242,
-0.0030335532501339912,
-0.004092639312148094,
0.022499796003103256,
0.017123863101005554,
-0.017285067588090897,
-0.008757174015045166,
-0.0456065833568573,
-0.029078638181090355,
0.00036534806713461876,
0.01335124857723713,
-0.021039143204689026,
-0.020815981552004814,
-0.016675040125846863,
-0.005888639483600855,
0.02484089508652687,
-0.02189321629703045,
0.0020289472304284573,
-0.004162090364843607,
-0.025752656161785126,
0.008392924442887306,
0.006125953048467636,
-0.012677285820245743,
-0.006884000729769468,
-0.014459695667028427,
0.002814593492075801,
0.025891629979014397,
-0.03358219563961029,
0.03663628548383713,
0.07445305585861206,
-0.015906956046819687,
-0.07404594123363495,
0.002781776711344719,
-0.009084506891667843,
-0.01733720302581787,
-0.018409844487905502,
0.015632253140211105,
-0.024591851979494095,
-0.005587362218648195,
-0.0296042338013649,
0.0001992735778912902,
-0.047702301293611526,
0.014798786491155624,
0.022360410541296005,
-0.006470557767897844,
0.014426145702600479,
0.0020815948955714703,
0.005394252948462963,
0.004054871387779713,
-0.0009765801951289177,
-0.0034841238521039486,
0.011141975410282612,
0.06092888116836548,
-0.019055113196372986,
0.0021984276827424765,
0.005186799913644791,
-0.08069060742855072,
-0.006397073622792959,
0.0006714013870805502,
-0.022144656628370285,
0.01041470468044281,
-0.030157843604683876,
0.02045048400759697,
-0.015621596947312355,
0.01242778729647398,
-0.01879252679646015,
0.0016692467033863068,
0.003877566894516349,
0.005706873722374439,
-0.020531432703137398,
0.023976365104317665,
-0.009145259857177734,
0.004093266557902098,
0.0041149817407131195,
-0.00432239705696702,
0.007064740173518658,
0.04517051577568054,
-0.00026242947205901146,
-0.010011718608438969,
0.010933606885373592,
-0.012206471525132656,
-0.03387497365474701,
0.005420780275017023,
0.008313681930303574,
0.037027567625045776,
-0.028949152678251266,
-0.020541150122880936,
-0.01939208060503006,
-0.01203875057399273,
0.01235940121114254,
-0.02856258489191532,
-0.01156306080520153,
0.0009737492073327303,
0.01874798908829689,
0.0034038033336400986,
-0.01027645356953144,
-0.0038675693795084953,
-0.015267213806509972,
-0.020218834280967712,
-0.009545205160975456,
-0.024117056280374527,
-0.025268979370594025,
0.005090659484267235,
-0.009627163410186768,
0.023453762754797935,
-0.022718895226716995,
0.007804933004081249,
-0.0081289978697896,
0.016274239867925644,
-0.028339089825749397,
-0.012508030980825424,
-0.004174470901489258,
-0.011576669290661812,
0.010671158321201801,
0.01724279299378395,
-0.00985814444720745,
-0.002521120011806488,
0.03059247136116028,
0.008433274924755096,
0.07142137736082077,
-0.038645319640636444,
-0.007874159142374992,
0.004190113395452499,
0.007896263152360916,
0.0008630517404526472,
-0.04304087162017822,
-0.009909362532198429,
0.009537304751574993,
-0.006372727453708649,
0.014646927826106548,
-0.008479821495711803,
0.0013443166390061378,
0.0072817327454686165,
0.013094887137413025,
0.017396874725818634,
0.028827782720327377,
-0.01580476015806198,
-0.03651784360408783,
-0.01202717050909996,
-0.032919906079769135,
0.018207376822829247,
-0.012645307928323746,
0.008894085884094238,
0.00981920026242733,
-0.0085027776658535,
0.011619037948548794,
-0.014568177983164787,
0.024605365470051765,
-0.028068680316209793,
0.017559953033924103,
-0.032421305775642395,
0.0011292496928945184,
0.019394727423787117,
0.00988573208451271,
0.015713505446910858,
0.044631227850914,
-0.0032318446319550276,
-0.03124130517244339,
0.014025092124938965,
0.008922363631427288,
-0.0016848640516400337,
0.006952331401407719,
-0.020200790837407112,
-0.00020958681125193834,
0.0014635305851697922,
0.023840725421905518,
-0.018595751374959946,
0.020634908229112625,
0.00990276224911213,
0.011081414297223091,
-0.004563016351312399,
-0.009555578231811523,
-0.004713473841547966,
-0.0012487780768424273,
0.018745819106698036,
0.01368019264191389,
0.020006733015179634,
0.0104650454595685,
-0.012150244787335396,
-0.005443088244646788,
-0.012745212763547897,
-0.021731486544013023,
-0.022014984861016273,
0.010532365180552006,
0.006194064859300852,
0.013835227116942406,
-0.015442833304405212,
-0.017929591238498688,
0.017521608620882034,
0.039920270442962646,
0.008115895092487335,
0.008478416129946709,
0.0064329407177865505,
0.015112125314772129,
-0.00900726206600666,
0.0039051200728863478,
0.0037766238674521446,
0.0101842749863863,
-0.008173859678208828,
-0.0018899630522355437,
-0.012092191725969315,
-0.009978421963751316,
0.01587335579097271,
0.04491303116083145,
-0.020757591351866722,
0.01099376194179058,
0.02185978554189205,
-0.00829513743519783,
0.008118705824017525,
-0.030899953097105026,
0.00030109588988125324,
0.0018619538750499487,
0.016101326793432236,
0.007322506979107857,
0.03493200242519379,
0.002884495072066784,
-0.0035625402815639973,
-0.01641567051410675,
-0.005672814790159464,
-0.012037646025419235,
-0.013387223705649376,
0.0034181647934019566,
0.028788989409804344,
0.02039080671966076,
-0.006558526307344437,
0.01104698982089758,
-0.026462100446224213,
0.006192472297698259,
0.006379278842359781,
-0.057780951261520386,
0.010832599364221096,
0.006015524733811617,
0.029979344457387924,
0.015549766831099987,
0.030133618041872978,
-0.028102004900574684,
0.0007614279165863991,
0.03710272163152695,
-0.010669685900211334,
0.0061164721846580505,
0.008630550466477871,
0.004795495420694351,
0.007932365871965885,
-0.0046274736523628235,
-0.03237009048461914,
-0.008751698769629002,
-0.0075704315677285194,
0.03459044173359871,
-0.0012181559577584267,
0.015287484973669052,
0.0027882978320121765,
-0.020097700878977776,
0.046523213386535645,
0.008609838783740997,
0.022586096078157425,
0.0005414404440671206,
-0.010129380971193314,
-0.04162145406007767,
0.005751736927777529,
0.029169972985982895,
0.004790065810084343,
-0.0008109444752335548,
0.0030488469637930393,
0.007606976665556431,
-0.0044754729606211185,
0.015966420993208885,
0.006279246881604195,
0.016907723620533943,
0.009612955152988434,
-0.006049063056707382,
-0.004891358781605959,
-0.01285571325570345,
-0.00396325346082449,
-0.0252792127430439,
0.01559722051024437,
0.013614032417535782,
0.007272116839885712,
-0.020865263417363167,
-0.02328253537416458,
-0.007384886499494314,
0.010230504907667637,
0.007036443799734116,
0.0015651588328182697,
0.01292942464351654,
-0.008100192062556744,
-0.004847606644034386,
-0.018778881058096886,
-0.0067737228237092495,
0.007281094789505005,
0.03595588728785515,
0.009860614314675331,
-0.019472412765026093,
0.01419014297425747,
-0.010442191734910011,
-0.01989557407796383,
-0.0019282709108665586,
-0.0009744300041347742,
0.014372019097208977,
0.03252498805522919,
0.02900884672999382,
-0.04002302512526512,
-0.0029266737401485443,
-0.011432445608079433,
-0.005294281989336014,
-0.008166352286934853,
-0.01196583267301321,
-0.009131956845521927,
0.010686857625842094,
0.03382761403918266,
-0.027160078287124634,
-0.021950865164399147,
0.001029863371513784,
-0.0060489787720143795,
0.00847098883241415,
0.010794360190629959,
0.03338966518640518,
-0.023638533428311348,
-0.0031941914930939674,
0.00037428352516144514,
0.007928612641990185,
-0.00516478018835187
] | [
0.2058783769607544,
-0.0778857171535492,
0.004646794404834509,
-0.06694383174180984,
0.12291157245635986,
0.2471572756767273,
0.05995768681168556,
-0.4275418221950531,
-0.1526576429605484,
-0.8001810908317566,
0.041766729205846786,
0.5072280168533325,
0.20559369027614594,
-0.12695667147636414,
0.020504198968410492,
0.4586179852485657,
0.5610833764076233,
0.0353999137878418,
-0.16239319741725922,
-0.36820870637893677,
0.054405659437179565,
0.02083347551524639,
0.3411395251750946,
-0.30887699127197266,
0.1388709545135498,
0.009110771119594574,
0.5385680198669434,
0.4759563207626343,
-0.16231854259967804,
-0.5285401940345764,
-0.1903117150068283,
-0.05595525726675987,
0.06745360791683197,
-0.47347313165664673,
-0.06574476510286331,
0.10379460453987122,
-0.04559136554598808,
-0.30966585874557495,
-0.04237726703286171,
-0.42495474219322205,
-0.39854666590690613,
0.19884271919727325,
-0.0015341161051765084,
0.7446097135543823,
0.3190162777900696,
-0.15421022474765778,
-1.452027678489685,
-0.34735217690467834,
-0.24072284996509552,
0.37763166427612305,
0.28723251819610596,
0.21437890827655792,
0.5076719522476196,
0.10054479539394379,
0.16943852603435516,
-0.3710898756980896,
-0.26207298040390015,
-0.3980127274990082,
0.01962071843445301,
-0.025773681700229645,
0.26841792464256287,
0.6235889196395874,
-0.054315511137247086,
0.4061872065067291,
0.04055899381637573,
0.5921621322631836,
0.2671005129814148,
0.3191327154636383,
0.09397216886281967,
-0.1366470903158188,
0.10658515244722366,
-0.44595810770988464,
-0.20345526933670044,
0.4290783703327179,
0.4041421413421631,
0.1285254806280136,
0.22998780012130737,
-0.09192050993442535,
0.22906020283699036,
-0.4558671712875366,
0.3676133155822754,
0.1857195645570755,
0.5034734010696411,
-0.34084853529930115,
0.5056169629096985,
0.13683269917964935,
-0.2225378453731537,
0.3989965319633484,
-0.37144482135772705,
-0.06389998644590378,
-0.32397401332855225,
-0.30903807282447815,
0.18740113079547882,
0.18853017687797546,
0.3017021715641022,
0.03224777802824974,
0.12682120501995087,
-0.2887990176677704,
0.27552154660224915,
0.2471335083246231,
0.041637636721134186,
0.138107031583786,
0.07599048316478729,
0.11156272143125534,
0.16861741244792938,
-0.17593923211097717,
-0.1772156059741974,
-0.48639944195747375,
-0.5647403001785278,
0.5643714070320129,
-0.8208377957344055,
0.20124612748622894,
-0.09579163044691086,
-0.3313503861427307,
-0.20799410343170166,
0.4218594431877136,
0.18963271379470825,
-0.18636569380760193,
-0.813036322593689,
0.22863689064979553,
-0.12185335159301758,
0.3837423324584961,
-0.039452873170375824,
0.2668170928955078,
0.09239693731069565,
0.10921938717365265,
0.609156608581543,
0.6410972476005554,
-0.08932424336671829,
0.6373088955879211,
-0.08170841634273529,
0.3085693120956421,
-0.3369668126106262,
-0.33691132068634033,
-0.16055697202682495,
-0.4247353672981262,
0.14873751997947693,
0.6064000129699707,
0.020526127889752388,
0.4242647588253021,
0.03884612023830414,
0.012744497507810593,
-0.18603135645389557,
-0.3208203613758087,
-0.266689270734787,
-0.3802948594093323,
0.008046209812164307,
0.09750448167324066,
-0.4422929584980011,
0.19230885803699493,
0.12470970302820206,
0.14713464677333832,
-0.4845147728919983,
0.18887266516685486,
-0.2715381979942322,
0.8447811603546143,
0.01375641580671072,
-0.116904117166996,
-0.3100699484348297,
0.2091045081615448,
0.8576517105102539,
0.047011714428663254,
-0.39396044611930847,
-0.10895133763551712,
0.48707515001296997,
-0.04313569888472557,
0.207086443901062,
-0.37707340717315674,
0.8399389386177063,
-0.10796131938695908,
-0.24076543748378754,
0.25921201705932617,
-0.5359101891517639,
-0.8690657019615173,
0.1020243912935257,
0.7028236985206604,
0.5720393061637878,
0.5053694248199463,
0.07209841907024384,
0.24009506404399872,
-0.44088372588157654,
-0.6541182398796082,
-0.22552451491355896,
-0.7577877640724182,
0.5418437123298645,
-0.4013039171695709,
0.7625234127044678,
0.005712061654776335,
0.4332889914512634,
-0.013016426004469395,
0.22092531621456146,
-0.3595985472202301,
0.5276203751564026,
-0.5585537552833557,
1.3658473491668701,
-0.1623297482728958,
-0.3168068528175354,
1.1187872886657715,
-0.35840144753456116,
0.23939695954322815,
0.3984086513519287,
0.7068476676940918,
0.5368329286575317,
0.5226607322692871,
-0.8231090903282166,
-0.15745031833648682,
0.14929796755313873,
-0.464242160320282,
-0.5126412510871887,
0.22283391654491425,
0.41378235816955566,
-0.3136937916278839,
-0.37331295013427734,
-0.5043404698371887,
0.3852321207523346,
-0.0040735104121267796,
0.21875305473804474,
-0.09967540204524994,
-0.3942030370235443,
0.20261217653751373,
0.5435852408409119,
0.027377627789974213,
0.5885276198387146,
0.5413981676101685,
-0.24301500618457794,
0.6333581209182739,
0.344408243894577,
0.10268440842628479,
0.3160187900066376,
-0.5670577883720398,
-0.03132856637239456,
0.14631077647209167,
0.45077937841415405,
-0.4243433177471161,
-0.0007951919105835259,
-0.07198082655668259,
-0.02028905600309372,
-0.5380126237869263,
-0.03641294687986374,
0.09150023013353348,
0.14282523095607758,
0.17363615334033966,
-0.8483299016952515,
0.24843595921993256,
0.3237290680408478,
-0.5017473697662354,
-0.35556817054748535,
0.5812215805053711,
-0.6513310670852661,
-0.17488820850849152,
0.28262487053871155,
0.18727868795394897,
0.5992376804351807,
-0.3081001043319702,
-0.044762022793293,
0.5101950764656067,
-0.7533258199691772,
-0.4838795065879822,
0.4147689640522003,
-0.07753698527812958,
-0.3255002796649933,
0.5623248815536499,
0.44894838333129883,
0.6757250428199768,
-0.050607047975063324,
-0.14830313622951508,
-0.8630205392837524,
-0.4917256236076355,
0.10308782011270523,
0.6435010433197021,
0.33919718861579895,
0.27852654457092285,
-1.0169527530670166,
-0.2600031793117523,
-0.5030296444892883,
-0.21393989026546478,
0.5644245147705078,
0.5605038404464722,
-0.5724157094955444,
-0.7983047366142273,
0.022259900346398354,
0.7289716601371765,
1.0160690546035767,
0.039922598749399185,
-0.39845654368400574,
-0.13216370344161987,
-0.281029611825943,
-0.233512744307518,
-0.7211123108863831,
-0.07423415780067444,
0.3073689043521881,
0.6728511452674866,
-0.46098777651786804,
-0.10713460296392441,
0.7809114456176758,
0.1918703317642212,
-0.08882589638233185,
0.423464298248291,
0.44036659598350525,
-0.09264611452817917,
0.38389137387275696,
0.1486675888299942,
0.007264253217726946,
0.10507216304540634,
0.14068308472633362,
-0.60197913646698,
-0.5550737380981445,
0.08066285401582718,
-5.881255149841309,
-0.36785146594047546,
-0.3721289336681366,
-0.06633315235376358,
-0.2115323841571808,
0.1336209923028946,
0.9170809984207153,
-0.21385201811790466,
-0.0056979479268193245,
0.06070508807897568,
0.10952939838171005,
0.7275843024253845,
0.41365960240364075,
0.20937399566173553,
0.0012771427864208817,
0.40880709886550903,
0.10254403203725815,
-0.29073280096054077,
0.4041307866573334,
0.4257948100566864,
0.043521180748939514,
-0.2153005450963974,
-0.013654435984790325,
0.6802804470062256,
0.4388563930988312,
0.1544083207845688,
-0.9549404978752136,
0.8105630874633789,
-0.15872806310653687,
0.005688047967851162,
0.6792054176330566,
-0.33935004472732544,
-0.4314270317554474,
-0.4680759310722351,
0.13863015174865723,
0.21739408373832703,
0.17145183682441711,
0.0007601890829391778,
0.0428788997232914,
-0.590700626373291,
-0.16743452847003937,
0.16001568734645844,
-0.12183551490306854,
0.13059945404529572,
0.28104087710380554,
0.0007113592582754791,
0.05605003237724304,
0.21626214683055878,
-0.3118935227394104,
1.0814176797866821,
-0.13974997401237488,
0.09767046570777893,
0.39291641116142273,
0.896405816078186,
-0.0015186845557764173,
-0.23758217692375183,
-0.08223354071378708,
0.10175514966249466,
-0.4258122146129608,
0.35099443793296814,
-0.23210753500461578,
-0.5722912549972534,
0.006914648227393627,
-0.8986600637435913,
-0.19860076904296875,
-0.04867813363671303,
-0.8428887724876404,
-0.23263266682624817,
0.2036910206079483,
0.258476585149765,
-0.39854735136032104,
0.1760559231042862,
0.4310169219970703,
-0.9107959866523743,
0.36659643054008484,
-0.277084618806839,
-0.30243751406669617,
-0.113070547580719,
-0.28874626755714417,
-0.444640576839447,
-0.018660040572285652,
-0.20866146683692932,
0.08799931406974792,
0.31151825189590454,
0.172285258769989,
-0.0965915396809578,
-0.2483246624469757,
-0.34694868326187134,
-0.45200252532958984,
-0.1416207104921341,
0.38023850321769714,
-0.018077204003930092,
0.022723885253071785,
0.22608384490013123,
0.211164653301239,
0.5596425533294678,
0.20529073476791382,
-0.010323790833353996,
0.4198734760284424,
-0.49133557081222534,
0.9182459712028503,
-0.042497631162405014,
-0.18230216205120087,
-0.846304178237915,
-0.06929700821638107,
-0.37212952971458435,
-0.7143933773040771,
-0.09312567859888077,
0.6315662860870361,
-1.0057779550552368,
-0.38906142115592957,
-0.5979248285293579,
-0.7511700987815857,
-0.19664648175239563,
0.1288360357284546,
0.34857165813446045,
-0.3080286681652069,
-0.34360381960868835,
0.3378202021121979,
-0.14742827415466309,
0.02334795705974102,
0.11012767255306244,
-0.047845322638750076,
0.0021635331213474274,
0.13299867510795593,
-0.13590654730796814,
0.23120592534542084,
0.5621510744094849,
-0.6163858771324158,
0.1477823108434677,
0.5750178694725037,
0.8032251000404358,
-0.5011373162269592,
-0.0721864253282547,
0.10286813974380493,
-0.7275323271751404,
-0.4567011594772339,
0.19847168028354645,
-0.0703267753124237,
0.20760807394981384,
0.022186199203133583,
-0.45616278052330017,
-0.006112102419137955,
-0.40851306915283203,
0.5128836035728455,
-0.2531529366970062,
-0.2608402371406555,
-0.01595544070005417,
-0.7125746607780457,
0.16582255065441132,
0.4002089202404022,
-0.28647559881210327,
0.6927595138549805,
-0.126615509390831,
-0.1287861168384552,
0.039978381246328354,
0.44089415669441223,
0.39129090309143066,
-0.006718895398080349,
-0.3018633723258972,
0.42329394817352295,
-0.2782343327999115,
-0.5787432789802551,
-0.24156400561332703,
0.3770792782306671,
-0.16295862197875977,
-0.48545554280281067,
-0.7521950602531433,
-0.18316586315631866,
0.16344790160655975,
0.13602875173091888,
-0.17730309069156647,
-0.43807968497276306,
-0.1933472454547882,
0.2828339636325836,
-0.15644901990890503,
-0.4295397400856018,
0.29872146248817444,
-0.1183999553322792,
-0.2503395080566406,
0.276282399892807,
-0.8994404077529907,
-0.16971375048160553,
0.24225610494613647,
0.9018598794937134,
0.16742031276226044,
-0.09331125020980835,
-0.39469602704048157,
-0.1280607134103775,
-0.4095703661441803,
0.19669657945632935,
0.23872290551662445,
0.5614140033721924,
-0.15337471663951874,
-0.17642660439014435,
-0.3394036591053009,
0.2102775126695633,
0.16618795692920685,
-0.41609811782836914,
-0.5161113142967224,
-0.03830113634467125,
0.09613662213087082,
-0.34750786423683167,
0.7154706716537476,
0.79661625623703,
-0.37489116191864014,
0.09726931899785995,
-0.1662319451570511,
-0.5917394757270813,
0.06858008354902267,
0.38109520077705383,
-0.6174740791320801,
-0.03472302481532097,
0.10866256803274155,
-0.48474249243736267,
0.2712502181529999,
-0.2832159698009491,
-0.4216804504394531,
-0.6180317401885986,
0.31152358651161194,
0.27300357818603516,
-0.3706994652748108,
-0.6885724663734436,
-0.00020549813052639365,
-0.23709715902805328,
-0.33057743310928345,
0.9472232460975647,
-0.7239218354225159,
-0.129347562789917,
-0.05496448278427124,
-0.597665011882782,
-0.03283904120326042,
0.15268145501613617,
-0.24658656120300293,
-0.5301955938339233,
0.1473621129989624,
-0.7184386253356934,
0.10898075252771378,
0.1774851381778717,
0.492692232131958,
-0.2229689359664917,
0.8193121552467346,
-0.23850032687187195,
-0.617700457572937,
0.261608362197876,
0.2216654270887375,
0.13103583455085754,
-0.7238683700561523,
-0.37931448221206665,
0.4769417345523834,
0.1453293412923813,
0.0014985790476202965,
0.03374486789107323,
-0.23024947941303253,
0.4419540464878082,
-0.13445408642292023,
-0.2831781804561615,
-0.38290148973464966,
-0.28172823786735535,
0.2866661548614502,
0.05310727283358574,
-0.04705582931637764,
-0.4984687864780426,
-0.12479908764362335,
0.09973625838756561,
-0.44812238216400146,
0.06110811233520508,
-0.49950942397117615,
0.3577377200126648,
-0.5196025967597961,
-0.6272344589233398,
-0.2557641863822937,
0.13383804261684418,
0.36337539553642273,
0.1906566023826599,
-0.14037209749221802,
-0.19335992634296417,
-0.5004481077194214,
0.1207849308848381,
0.49323639273643494,
0.034915752708911896,
-0.4393235146999359,
-0.11410952359437943,
-0.14288386702537537,
0.6722779870033264,
-0.08617538213729858,
0.22003629803657532,
0.41716015338897705,
0.05075783282518387,
-0.06186199560761452,
-0.03432634100317955,
0.38612762093544006,
-0.7114704251289368,
-0.04759499803185463,
0.2808791399002075,
0.49530139565467834,
0.35085055232048035,
-0.2400497943162918,
0.11911071091890335,
-0.2286716103553772,
0.12648722529411316,
0.8244893550872803,
0.48730385303497314,
-0.23953905701637268,
-0.062136195600032806,
0.3289310336112976,
-0.10214747488498688,
-0.28196170926094055,
-0.3133070766925812,
0.2757890224456787,
0.542630136013031,
-0.3246558904647827,
0.36825278401374817,
0.6808218955993652,
-0.4044702649116516,
-0.0465051531791687,
-0.13820405304431915,
-0.25962963700294495,
0.24349910020828247,
0.14641901850700378,
-0.06139548867940903,
0.8012089133262634,
0.662221372127533,
-0.2781350612640381,
-0.592133641242981,
0.24084289371967316,
-0.30703839659690857,
0.06442401558160782,
-0.15287268161773682,
0.012213874608278275,
0.6071823835372925,
0.8128275275230408,
0.11918888986110687,
0.28721579909324646,
0.3881581723690033,
0.12667216360569,
0.6803260445594788,
-0.3179640769958496,
-0.0032295607961714268,
-0.5178203582763672,
0.3926365375518799,
0.42452484369277954,
-0.05200465768575668,
0.04496081918478012,
0.0740419328212738,
0.027508798986673355,
-0.3023037910461426,
0.21402709186077118,
-0.0920049250125885,
0.10463467240333557,
-0.023329168558120728,
0.3117252588272095,
-0.38925135135650635,
-0.2128763347864151,
-0.2780218720436096,
0.25630107522010803,
0.30181625485420227,
-0.3985252380371094,
-0.43830451369285583,
0.10480400174856186,
0.2681206166744232,
0.5180680155754089,
-0.4462645351886749,
0.11123217642307281,
-0.3425348103046417,
0.1730514019727707,
0.7420390248298645,
0.43229609727859497,
0.29661330580711365,
-0.1962316334247589,
-0.2045670598745346,
0.3215082585811615,
-0.5179702639579773,
-0.08564721792936325,
-0.04925159364938736,
-0.8037049770355225,
0.293607622385025,
-0.2845883071422577,
0.18817782402038574,
0.37283796072006226,
0.3946394920349121,
-0.11699628829956055,
-0.3969680964946747,
-0.6782545447349548,
0.24062016606330872,
0.06442016363143921,
0.06475841253995895,
0.40104615688323975,
-0.3656401038169861,
0.13075879216194153,
-0.6186524629592896,
-0.6529890894889832,
0.15056096017360687,
0.12027674913406372,
-0.003897475777193904,
-0.25120171904563904,
-0.3182528018951416,
0.8594732284545898,
0.10817530751228333,
-0.0536571629345417,
-0.28932246565818787,
-0.2310829907655716,
-0.1694236546754837,
0.2422163188457489,
-0.10896312445402145,
0.9255227446556091,
-0.7881901264190674,
0.04207678511738777,
-0.47677940130233765,
0.16163036227226257,
0.6519390940666199,
0.9364650249481201,
-0.31283992528915405,
0.05643795430660248,
0.11908862739801407,
0.3308555781841278,
0.13126756250858307,
-0.4528099596500397,
-0.3745344579219818,
-0.37373900413513184,
-0.47217828035354614,
-0.13917310535907745,
0.49604716897010803,
0.13343270123004913,
-0.49143972992897034,
-0.5652393698692322,
0.026409324258565903,
0.7134664058685303,
0.11388792842626572,
0.05132801830768585,
0.07040142267942429,
-0.4967063069343567,
-0.480937659740448,
0.53685063123703,
-0.06189384683966637,
0.19446530938148499,
0.13135848939418793,
0.24231398105621338,
0.06549371778964996,
0.175617977976799,
-0.11364313215017319,
-0.16484911739826202,
0.1483403742313385,
0.5954816341400146,
-0.1278686821460724,
0.08814144879579544,
-0.25539013743400574,
-0.39455515146255493,
-0.41014260053634644,
0.24124032258987427,
0.06112397834658623,
-0.01363725308328867,
-0.5836729407310486,
-0.3561561703681946,
-0.08094477653503418,
-0.023228803649544716,
-0.3847254514694214,
-0.355339378118515,
-0.22825808823108673,
-0.19439542293548584
] |
Background/Aims: Osteoarthritis (OA) is a multifactorial disease that is associated with inflammation in joints. The purpose of the present study was to investigate the anti-inflammatory activity and mechanism of morin on human osteoarthritis chondrocytes stimulated by IL-1β. Methods: The levels of NO and PGE2 were measured by the Griess method and ELISA. The levels of MMP1, MMP3, and MMP13 were also measured by ELISA. Results: The results revealed that IL-1β significantly increased the production of NO, PGE2, MMP1, MMP3, and MMP13. Additionally, the increases were significantly attenuated by treatment with morin. Furthermore, IL-1β-induced NF-κB activation was suppressed by morin. In addition, the expression of Nrf2 and HO-1 were increased by morin and knockdown of Nrf2 could prevent the anti-inflammatory effects of morin. Conclusion: In conclusion, this study suggested that morin attenuated IL-1β-induced inflammation by activating the Nrf2 signaling pathway. | [
-0.010198281146585941,
0.008056802675127983,
-0.020638834685087204,
0.013638785108923912,
0.0027535432018339634,
0.012306109070777893,
0.009894215501844883,
-0.023208927363157272,
-0.009286323562264442,
0.008328944444656372,
-0.001566528808325529,
0.003965908661484718,
-0.013547411188483238,
0.007559242658317089,
-0.001443643355742097,
-0.024443969130516052,
-0.02690088003873825,
0.01851596310734749,
0.013906163163483143,
0.02832363173365593,
-0.005141429603099823,
-0.013201632536947727,
0.011043713428080082,
-0.005811433773487806,
0.021602235734462738,
0.033099621534347534,
-0.0163379218429327,
-0.01704401522874832,
-0.011169619858264923,
0.008541570976376534,
-0.015714576467871666,
0.004948889836668968,
-0.016231831163167953,
-0.00635689590126276,
0.004033995792269707,
-0.03549746051430702,
-0.006605180911719799,
0.014063376002013683,
-0.0000673346221446991,
-0.005455649923533201,
0.002138991840183735,
-0.014059662818908691,
0.015806380659341812,
-0.029394082725048065,
-0.010692514479160309,
-0.016206391155719757,
-0.003405231749638915,
-0.017661897465586662,
0.00228024460375309,
0.011170604266226292,
-0.011484296061098576,
-0.009599428623914719,
-0.015769176185131073,
-0.0003530047833919525,
-0.006802863907068968,
0.03852102905511856,
0.01752626895904541,
0.007568203844130039,
-0.01674378477036953,
0.011774560436606407,
0.014205774292349815,
-0.0007824799977242947,
-0.003570868633687496,
-0.0056110164150595665,
-0.009609238244593143,
-0.06654900312423706,
0.004125129897147417,
-0.0014784925151616335,
-0.002283229026943445,
-0.0006630038842558861,
-0.03198563680052757,
0.015328831039369106,
0.012041661888360977,
0.01596253551542759,
-0.00865691713988781,
0.00006595347076654434,
0.005962378345429897,
-0.02010081708431244,
0.008124465122818947,
0.03426777943968773,
-0.0035112514160573483,
-0.008563712239265442,
0.0014566127210855484,
0.01861034892499447,
0.020050838589668274,
0.018336575478315353,
-0.02256225049495697,
-0.006757612805813551,
-0.01089335884898901,
0.030175384134054184,
0.020677510648965836,
-0.003954813349992037,
-0.006499682553112507,
-0.0018923550378531218,
-0.013326994143426418,
0.018856465816497803,
0.01377759501338005,
0.01799590140581131,
0.000991892535239458,
-0.009077081456780434,
-0.007917873561382294,
0.014445066452026367,
0.024396810680627823,
0.004598795436322689,
0.008659208193421364,
0.010982452891767025,
0.002409331500530243,
0.0011198732536286116,
0.013930851593613625,
0.004929511807858944,
-0.01666266657412052,
0.015601592138409615,
-0.0049087111838161945,
0.04139960929751396,
0.02164001576602459,
-0.01384598109871149,
-0.008766241371631622,
0.01740119606256485,
0.005499973893165588,
0.012143625877797604,
0.01202385313808918,
0.008626004680991173,
-0.0020423128735274076,
0.01735590025782585,
-0.004440681543201208,
0.004698288626968861,
0.03291274607181549,
-0.0034503252245485783,
0.012309038080275059,
0.006663297303020954,
-0.007089062128216028,
0.014962427318096161,
0.014543176628649235,
0.012028878554701805,
-0.011255931109189987,
-0.00035332076367922127,
0.012787393294274807,
0.00831102766096592,
-0.006097696255892515,
0.002107869368046522,
0.0008632331155240536,
0.006217366550117731,
0.00045232579577714205,
0.012574472464621067,
0.034398745745420456,
0.0015359526732936502,
0.0488249696791172,
0.007002227008342743,
-0.020216308534145355,
0.004261670634150505,
0.028636176139116287,
-0.016405194997787476,
-0.007262360770255327,
-0.013240981847047806,
-0.0010833838023245335,
0.012799887917935848,
-0.026951828971505165,
0.0227280892431736,
-0.012521445751190186,
-0.002506846794858575,
0.007630136329680681,
-0.023375075310468674,
0.016315851360559464,
0.009523271583020687,
-0.01117389090359211,
0.015394160524010658,
-0.0010136105120182037,
-0.007343449164181948,
-0.004151212051510811,
0.009071370586752892,
-0.002914764452725649,
-0.03137337416410446,
-0.026121772825717926,
0.011475893668830395,
-0.009511674754321575,
-0.011693963780999184,
0.005845614243298769,
0.00826018676161766,
-0.0004256421234458685,
0.06579570472240448,
0.016265664249658585,
-0.03199728578329086,
0.015428807586431503,
0.028328772634267807,
0.010741150006651878,
-0.010159293189644814,
0.002860195469111204,
-0.0104394955560565,
0.001052548410370946,
0.023316368460655212,
-0.025126434862613678,
0.0068284329026937485,
-0.004435158334672451,
-0.00560623686760664,
-0.042117197066545486,
0.003694416955113411,
0.02010703831911087,
0.003233218565583229,
-0.0058145830407738686,
0.001275515416637063,
0.026616040617227554,
-0.01918814145028591,
0.019447244703769684,
0.008575433865189552,
0.014406279660761356,
0.012451982125639915,
0.011678120121359825,
-0.0172128863632679,
-0.015639284625649452,
0.0032799341715872288,
0.015795651823282242,
0.011267472058534622,
-0.006621815729886293,
-0.016242574900388718,
0.022054271772503853,
0.001342204981483519,
-0.01696188561618328,
0.012016866356134415,
-0.027068614959716797,
-0.01419677585363388,
0.0022585385013371706,
0.0030659562908113003,
0.0178215354681015,
0.011808040551841259,
-0.0034187794663012028,
-0.007906617596745491,
0.0020435950718820095,
0.01227162592113018,
0.02918059751391411,
0.013470499776303768,
-0.03232356533408165,
0.013673096895217896,
-0.011645732447504997,
0.035139720886945724,
0.023348413407802582,
0.016813311725854874,
0.013761884532868862,
-0.011108014732599258,
0.009942913427948952,
-0.011197131127119064,
0.006034703925251961,
-0.00644976831972599,
0.015824859961867332,
-0.0023187920451164246,
0.011000925675034523,
-0.010980562306940556,
-0.0011246460489928722,
0.0023273341357707977,
0.018940435722470284,
0.022337617352604866,
0.007305361796170473,
0.010913819074630737,
-0.016982030123472214,
-0.029539939016103745,
0.016370609402656555,
-0.03320303186774254,
-0.017280593514442444,
-0.03506462275981903,
0.02717887982726097,
-0.013014968484640121,
0.004390272777527571,
0.00634932704269886,
0.017641223967075348,
0.008984792046248913,
-0.002347597386687994,
0.015565603971481323,
-0.012652216479182243,
0.01678493246436119,
0.02385021187365055,
0.003128527197986841,
0.007607505656778812,
-0.0076876115053892136,
-0.0005395070184022188,
-0.08138015866279602,
-0.010964609682559967,
-0.018198221921920776,
-0.005059407092630863,
0.01148984208703041,
-0.014613164588809013,
0.014628605917096138,
-0.00027133338153362274,
-0.0014583088923245668,
-0.005228571593761444,
0.00662597268819809,
-0.006146257743239403,
-0.010514834895730019,
0.011071793735027313,
-0.01044795848429203,
-0.0008858349174261093,
0.010528560727834702,
0.02125844731926918,
0.0010006804950535297,
-0.005157971289008856,
-0.011591927148401737,
-0.010058045387268066,
-0.019487911835312843,
0.009952965192496777,
0.020901579409837723,
-0.02901589125394821,
-0.005964039824903011,
0.000751431449316442,
0.017675381153821945,
0.000709950109012425,
-0.009398246183991432,
0.003891177009791136,
0.0029330351389944553,
0.015032889321446419,
0.02228405326604843,
-0.010954045690596104,
-0.006941324099898338,
0.00990072451531887,
-0.016863852739334106,
0.0018646195530891418,
-0.013869832269847393,
-0.004337583668529987,
0.026946472004055977,
-0.005434990394860506,
-0.0002574254758656025,
-0.00034922431223094463,
0.004028424620628357,
0.015542419627308846,
0.009497850202023983,
-0.014809644781053066,
0.01985062286257744,
0.0037432811222970486,
0.00863320380449295,
0.019148847088217735,
-0.0096800047904253,
-0.014056365936994553,
-0.023130325600504875,
-0.01494287233799696,
-0.0019400320015847683,
0.0012232072185724974,
0.02742600627243519,
-0.0076488531194627285,
0.012217435985803604,
0.012850260362029076,
-0.0024491033982485533,
0.0005042091943323612,
0.007966127246618271,
-0.005023622885346413,
-0.027325743809342384,
0.01919952593743801,
-0.019323091953992844,
0.009673107415437698,
-0.015432559885084629,
-0.009018043987452984,
0.0027197832241654396,
-0.014563348144292831,
-0.016042212024331093,
-0.007340595126152039,
0.005602026823908091,
-0.0005626028869301081,
-0.0512332059442997,
0.004383180756121874,
0.02607138454914093,
-0.006206185556948185,
-0.0174340158700943,
0.022287636995315552,
0.008077900856733322,
0.008962109684944153,
0.018045702949166298,
-0.01406803261488676,
0.011643988080322742,
0.051659923046827316,
0.03242161124944687,
0.01813983917236328,
0.009998650290071964,
0.003041671123355627,
-0.00993616133928299,
0.011078347451984882,
0.030045010149478912,
0.008387444540858269,
-0.009422870352864265,
-0.008661661297082901,
-0.008077462203800678,
-0.008829236961901188,
-0.01176345907151699,
0.014404003508388996,
-0.01316116750240326,
0.020738983526825905,
-0.0033422736451029778,
-0.001907126046717167,
-0.0010191970504820347,
-0.0001970257144421339,
0.001827038824558258,
0.015253016725182533,
0.009281372651457787,
-0.02495567873120308,
-0.002866265596821904,
0.021793629974126816,
0.07211510092020035,
-0.01471230573952198,
0.002869921736419201,
-0.013440599665045738,
0.025565139949321747,
-0.019533632323145866,
-0.027512837201356888,
0.015551412478089333,
0.01588619127869606,
-0.0008177695563063025,
0.014284307137131691,
-0.0010215099900960922,
-0.015954915434122086,
0.012463334947824478,
-0.015686221420764923,
0.012957604601979256,
-0.0033327077981084585,
-0.03272949904203415,
0.008371572010219097,
-0.009365521371364594,
-0.006047176197171211,
0.014363234862685204,
-0.01171341072767973,
-0.03102114424109459,
0.0022208818700164557,
-0.005501527339220047,
-0.010733036324381828,
-0.013194585219025612,
-0.01447957195341587,
0.013324652798473835,
-0.004474886693060398,
0.028484530746936798,
-0.01127920113503933,
0.020400429144501686,
0.01127585582435131,
-0.00825493410229683,
0.01850067637860775,
-0.010744255036115646,
0.013418077491223812,
-0.0018728610593825579,
-0.009931869804859161,
-0.012426204979419708,
0.014546295627951622,
0.008457894437015057,
-0.014293260872364044,
-0.0038376376032829285,
0.012330610305070877,
-0.009291224181652069,
-0.02346104010939598,
0.0008421221282333136,
0.000888200243934989,
0.004992834758013487,
0.007966110482811928,
0.008167237974703312,
0.00685924245044589,
0.0029208939522504807,
0.016852324828505516,
-0.00033524446189403534,
0.019867563620209694,
-0.003663955954834819,
-0.024843929335474968,
-0.01938355155289173,
0.03976278007030487,
-0.00828234851360321,
0.007330005057156086,
-0.00674020079895854,
0.015971792861819267,
-0.015054693445563316,
0.027602247893810272,
-0.0037656885106116533,
0.00036073033697903156,
0.016657888889312744,
-0.027558691799640656,
-0.018299508839845657,
-0.020954692736268044,
-0.026667514815926552,
-0.003862639656290412,
-0.02412339299917221,
-0.013782083056867123,
0.002034600358456373,
-0.025467287749052048,
0.012742533348500729,
-0.023502547293901443,
-0.008990710601210594,
0.01043727993965149,
0.005817153491079807,
-0.014975190162658691,
-0.0752682238817215,
-0.00812729261815548,
0.004003847483545542,
-0.005990863777697086,
-0.015260492451488972,
0.005137971602380276,
-0.007605596911162138,
-0.00019118469208478928,
-0.03476390615105629,
-0.0076942043378949165,
0.02915470115840435,
-0.005665387958288193,
0.02718013897538185,
-0.018721185624599457,
0.014057818800210953,
0.014432121068239212,
0.01955292373895645,
-0.009192602708935738,
0.004802187439054251,
-0.008092869073152542,
-0.012309063225984573,
0.016829529777169228,
-0.00400044210255146,
0.0032451804727315903,
-0.02189389243721962,
-0.08086616545915604,
-0.007570195477455854,
0.0019569997675716877,
-0.013254422694444656,
-0.022162459790706635,
0.025403345003724098,
0.0092826122418046,
0.006917086895555258,
0.0011636933777481318,
-0.014806076884269714,
0.024401120841503143,
0.0014527402818202972,
0.021164730191230774,
0.015749290585517883,
-0.011873625218868256,
-0.007632740773260593,
0.009241440333425999,
0.023936863988637924,
-0.005445553455501795,
0.029234187677502632,
0.0048906211741268635,
0.006894856691360474,
-0.004756974056363106,
0.0029202301520854235,
-0.024509459733963013,
-0.007054991088807583,
0.0008380298968404531,
0.021499186754226685,
-0.013321395963430405,
-0.025416003540158272,
-0.03249219059944153,
-0.029437631368637085,
-0.017761368304491043,
-0.025439422577619553,
-0.02091873809695244,
-0.009408114477992058,
0.0030495019163936377,
-0.012095564045011997,
-0.02404710091650486,
-0.012026827782392502,
-0.002901622327044606,
-0.012337535619735718,
-0.018377043306827545,
-0.006195513531565666,
-0.008816901594400406,
-0.02094338648021221,
0.005981397815048695,
-0.00539794284850359,
0.014636441133916378,
0.019467422738671303,
0.0121685229241848,
0.003254880430176854,
0.021891139447689056,
0.004726002458482981,
0.02143295481801033,
0.02071826346218586,
-0.017171762883663177,
0.023355204612016678,
0.012068499810993671,
0.0008976256940513849,
-0.014068420976400375,
0.012463090009987354,
0.02908625267446041,
0.07079590857028961,
-0.006845203693956137,
0.006720057222992182,
0.023288052529096603,
0.009450213052332401,
-0.002140154829248786,
-0.008995280601084232,
-0.03487798199057579,
0.0015597464516758919,
-0.00640125572681427,
0.003092993749305606,
-0.01184049155563116,
0.0013742982409894466,
0.009327910840511322,
-0.0007019136101007462,
0.013085385784506798,
-0.005868189036846161,
0.006099075078964233,
-0.009601852856576443,
-0.015506427735090256,
0.023810530081391335,
0.014281652867794037,
-0.01095803827047348,
-0.0013509421842172742,
0.015494883060455322,
-0.018747366964817047,
0.0002193031832575798,
0.010098768398165703,
-0.020144520327448845,
-0.00314436387270689,
-0.002977994969114661,
-0.034905754029750824,
-0.0008629938238300383,
0.014297658577561378,
0.031451232731342316,
0.00915063451975584,
0.01831592246890068,
0.013568801805377007,
-0.027075976133346558,
0.006381778046488762,
0.013581632636487484,
0.005059460178017616,
0.010095575824379921,
-0.004523588344454765,
0.024731500074267387,
0.02347450703382492,
0.015303146094083786,
0.019033292308449745,
0.0129013666883111,
-0.0081914272159338,
0.0002887691371142864,
-0.0029567405581474304,
0.0033329783473163843,
-0.00915445014834404,
0.006553484592586756,
-0.0020867919083684683,
-0.006363443564623594,
0.00855244230479002,
-0.019247431308031082,
-0.020641077309846878,
0.025116538628935814,
-0.022546246647834778,
-0.001247097970917821,
-0.02416359633207321,
-0.001625601900741458,
0.011845885775983334,
0.005041741766035557,
-0.010780087672173977,
-0.001157641876488924,
0.012612201273441315,
-0.009921109303832054,
0.019234834238886833,
0.01180728804320097,
0.009505241177976131,
0.05168269947171211,
0.0184601042419672,
0.009138413704931736,
-0.008680363185703754,
-0.000429860083386302,
0.010531248524785042,
-0.01527775451540947,
0.022001128643751144,
0.019861478358507156,
0.035173218697309494,
-0.010918673127889633,
0.008184945210814476,
0.010319679975509644,
0.006318410858511925,
-0.0004478954360820353,
0.010079040192067623,
-0.004687735345214605,
-0.0024502635933458805,
-0.0015805793227627873,
0.019566766917705536,
0.008554745465517044,
0.0350668840110302,
0.0037547480314970016,
0.006089377216994762,
-0.013827025890350342,
0.01819419488310814,
-0.021020695567131042,
0.01686594821512699,
-0.018636446446180344,
0.02449820563197136,
-0.0011585680767893791,
0.003285825252532959,
0.008901571854948997,
-0.012380875647068024,
0.0040883272886276245,
-0.0047470396384596825,
-0.010959912091493607,
0.017806611955165863,
0.018606459721922874,
0.024398311972618103,
0.010493309237062931,
0.026980694383382797,
-0.006559308618307114,
-0.010753137990832329,
-0.017349723726511,
-0.013430902734398842,
-0.011754341423511505,
-0.017973642796278,
-0.006057124584913254,
-0.025955457240343094,
0.00971827283501625,
-0.03747130185365677,
-0.009431769140064716,
-0.011229723691940308,
0.030070563778281212,
-0.009406452998518944,
0.023897074162960052,
0.017422879114747047,
-0.01988237351179123,
-0.008142956532537937,
0.008946667425334454,
-0.02511352300643921,
0.014572298154234886,
0.0032252285163849592,
-0.0023648624774068594,
-0.01063544861972332,
-0.00628617312759161,
0.003079725196585059,
0.005442442372441292,
-0.012672914192080498,
0.008795889094471931,
-0.016842570155858994,
-0.00568945100530982,
-0.017219381406903267,
0.005577291827648878,
0.029417458921670914,
0.023529142141342163,
0.002144027967005968,
0.013098882511258125,
-0.006428333930671215,
-0.013662660494446754,
0.01526786107569933,
-0.006836730055510998,
-0.008620810694992542,
-0.010695813223719597,
0.0041725896298885345,
-0.0020016422495245934,
0.006462381687015295,
0.0017935708165168762,
-0.00016206013970077038,
0.03121844120323658,
-0.01876901090145111,
-0.002130660694092512,
-0.002932540839537978,
0.014283044263720512,
-0.011642051860690117,
0.0037465370260179043,
-0.021880004554986954,
-0.005936845671385527,
0.03970247507095337,
-0.003756953403353691,
0.0012250683503225446,
0.0026453009340912104,
0.003923722542822361,
0.027633830904960632,
-0.0009944733465090394,
0.0013739729765802622,
0.0000819606939330697,
0.008496341295540333,
-0.011686671525239944,
0.00031267711892724037,
-0.007951653562486172,
-0.009019858203828335,
0.008361561223864555,
0.0006365565932355821,
0.02433488517999649,
-0.006144995801150799,
0.006540833972394466,
-0.019092261791229248,
0.000048399437218904495,
-0.0038778255693614483,
-0.012176020070910454,
-0.013420399278402328,
-0.02049499936401844,
-0.0033787405118346214,
-0.006842224393039942,
-0.007409075275063515,
-0.009756853803992271
] | [
0.10820142179727554,
0.3061806261539459,
0.10996680706739426,
-0.2998427152633667,
0.055469222366809845,
0.6492676138877869,
0.22496289014816284,
-0.02913488633930683,
-0.5075492262840271,
-0.1772967129945755,
-0.09181895852088928,
0.49326130747795105,
-0.03376112878322601,
-0.21695895493030548,
0.2178657203912735,
0.7677649855613708,
0.38520312309265137,
0.049070216715335846,
-0.6657314300537109,
-0.21451503038406372,
0.17151637375354767,
-0.2003166675567627,
0.38423019647598267,
-0.1884405016899109,
-0.14273323118686676,
0.14149953424930573,
0.2875555455684662,
0.25932812690734863,
0.24267135560512543,
-0.42189258337020874,
-0.3587668538093567,
0.7041316032409668,
0.21531197428703308,
-0.5985956788063049,
-0.35693642497062683,
0.16957470774650574,
-0.027318604290485382,
-0.057331718504428864,
0.12294277548789978,
-0.0285667572170496,
-0.26357606053352356,
-0.34916988015174866,
-0.041710738092660904,
0.3273906707763672,
-0.34382376074790955,
-0.2898867428302765,
-1.3784304857254028,
0.28135785460472107,
-0.28768831491470337,
0.30309414863586426,
0.25047874450683594,
0.35269904136657715,
0.1449330747127533,
-0.018308155238628387,
0.26819857954978943,
-0.09856017678976059,
-0.9250121116638184,
-0.4338316321372986,
0.11080708354711533,
-0.6380323171615601,
0.028388164937496185,
0.11808212846517563,
-0.06454528868198395,
0.024359168484807014,
-0.30425769090652466,
0.7889310121536255,
-0.15674367547035217,
0.20457670092582703,
-0.13296222686767578,
0.26819944381713867,
0.27981945872306824,
-0.18510055541992188,
-0.5041025876998901,
0.3302517533302307,
0.12346647679805756,
-0.32205623388290405,
0.15380015969276428,
0.016539739444851875,
0.12819847464561462,
0.11875870078802109,
0.355023056268692,
-0.09612006694078445,
1.0362855195999146,
-0.2732757329940796,
0.20018449425697327,
0.1212780624628067,
-0.2781829237937927,
0.7409690618515015,
-0.308646559715271,
-0.011870772577822208,
-0.19987809658050537,
0.10397090017795563,
0.7202901840209961,
0.665594220161438,
0.03519722446799278,
0.34610792994499207,
-0.020269349217414856,
-0.1986423134803772,
0.26070624589920044,
-0.019240884110331535,
0.04215173050761223,
0.10863403975963593,
-0.15274415910243988,
-0.08314713835716248,
0.11906447261571884,
0.3755735456943512,
-0.006308016832917929,
-0.33370980620384216,
-0.8456606864929199,
0.20623688399791718,
-1.1148622035980225,
0.1945727914571762,
-0.027997897937893867,
-0.5543924570083618,
0.08047329634428024,
-0.12281951308250427,
-0.17381355166435242,
-0.1812378168106079,
-0.21616707742214203,
0.3221885561943054,
0.34371432662010193,
1.0429396629333496,
0.12546084821224213,
0.4370157718658447,
0.19161108136177063,
0.07118461281061172,
0.13281592726707458,
0.12776613235473633,
-0.024003898724913597,
0.6959221363067627,
0.1303013265132904,
0.23262253403663635,
-0.3056595027446747,
0.22126010060310364,
0.12045415490865707,
-0.019635742530226707,
0.15979628264904022,
0.41548818349838257,
0.4222564399242401,
0.04236902669072151,
-0.5694893598556519,
-0.38112735748291016,
-0.4482520818710327,
0.13271880149841309,
-0.15152348577976227,
-0.7191551923751831,
-0.03189699351787567,
0.3483085632324219,
0.08925043791532516,
-0.15040570497512817,
-0.0814032033085823,
-0.4845258295536041,
-0.36389774084091187,
-0.19428789615631104,
-0.1697518229484558,
0.30783340334892273,
0.08434852212667465,
-0.33487221598625183,
-0.06334236264228821,
0.11803581565618515,
0.5791640877723694,
0.311684250831604,
-0.5995681285858154,
0.06971008330583572,
0.5541545748710632,
0.22520627081394196,
0.09627675265073776,
-0.17886003851890564,
0.3756295144557953,
0.2864784598350525,
-0.09990586340427399,
-0.33552783727645874,
0.1998455673456192,
-0.3430653214454651,
0.042181264609098434,
0.26371511816978455,
0.1781027913093567,
0.23544104397296906,
-0.11234841495752335,
0.404596209526062,
-0.8017694354057312,
-0.3240034282207489,
-0.09782977402210236,
-0.40893277525901794,
0.3764880895614624,
-0.1968330293893814,
0.5100663900375366,
-0.10271980613470078,
0.25153324007987976,
0.15204566717147827,
-0.4038449823856354,
0.07810866832733154,
0.9440257549285889,
-0.5741333365440369,
1.0775420665740967,
-0.39607059955596924,
-0.5285874009132385,
0.9578737020492554,
0.39943674206733704,
0.0941862165927887,
0.18084467947483063,
-0.16634880006313324,
0.5807387828826904,
-0.040125180035829544,
-0.40010589361190796,
0.14814697206020355,
-0.01911754161119461,
0.03888185694813728,
-0.09254181385040283,
0.13146713376045227,
0.22810564935207367,
-0.39378467202186584,
-0.13208964467048645,
-0.40832406282424927,
0.32855597138404846,
0.07560408115386963,
0.055852510035037994,
-0.10814783722162247,
-0.15110580623149872,
0.08163875341415405,
0.3138115704059601,
-0.5468143224716187,
0.46479615569114685,
0.37758031487464905,
-0.013924911618232727,
0.8235960602760315,
0.5933660268783569,
0.0019724194426089525,
0.8187735676765442,
-0.581989586353302,
0.26483938097953796,
0.12978346645832062,
0.2776029706001282,
-0.33550140261650085,
0.23465552926063538,
0.3308959901332855,
-0.15160126984119415,
-0.34412866830825806,
0.009461845271289349,
-0.18943189084529877,
-0.19798323512077332,
0.6783036589622498,
-0.5111576914787292,
0.10694406926631927,
0.014303349889814854,
-0.35858795046806335,
-0.1323564052581787,
0.14492912590503693,
-1.1571334600448608,
0.23505961894989014,
-0.14893695712089539,
0.018533172085881233,
0.0429968535900116,
-0.13385629653930664,
-0.12607115507125854,
0.03369045630097389,
0.022914262488484383,
-0.26366397738456726,
0.11391964554786682,
-0.42173048853874207,
-0.08569826930761337,
0.094708152115345,
0.555688202381134,
0.2611991763114929,
0.1193988099694252,
-0.35461100935935974,
-0.5220213532447815,
-0.35084962844848633,
0.6067795157432556,
0.32658058404922485,
0.8393377065658569,
0.0880739614367485,
-0.7864392995834351,
0.07762059569358826,
-0.11032275855541229,
-0.38866597414016724,
-0.4087814688682556,
0.6511443853378296,
-0.7143869996070862,
-0.6035763025283813,
-0.034737568348646164,
0.24658095836639404,
0.4316045045852661,
0.18986676633358002,
-0.19028744101524353,
-0.2604014277458191,
-0.409750759601593,
-0.13255631923675537,
-0.6789103746414185,
-0.5336016416549683,
-0.16243073344230652,
0.45563459396362305,
0.07990793138742447,
-0.27541089057922363,
0.29142630100250244,
0.266281396150589,
-0.12158884108066559,
0.6886825561523438,
0.660369873046875,
-0.5771058201789856,
-0.0755910649895668,
0.2602405846118927,
-0.24967758357524872,
-0.1130792573094368,
-0.08577155321836472,
-0.026880711317062378,
-0.545699417591095,
0.08922263979911804,
-6.107602119445801,
0.24641625583171844,
-0.43187952041625977,
-0.20725791156291962,
-0.19575002789497375,
0.05925179645419121,
1.054199457168579,
-0.17155484855175018,
0.046088166534900665,
-0.05026444047689438,
0.2370021492242813,
0.19317753612995148,
0.13643649220466614,
0.342408150434494,
-0.2631893754005432,
0.41989803314208984,
-0.20752020180225372,
-0.32139116525650024,
0.5113368630409241,
0.3955667316913605,
0.033083051443099976,
-0.47195398807525635,
-0.2685147523880005,
0.03102807141840458,
0.18882517516613007,
0.31752991676330566,
-1.0708026885986328,
0.47309330105781555,
-0.07556656002998352,
-0.24296844005584717,
0.4154232442378998,
-0.505272388458252,
-0.16563661396503448,
-0.29341235756874084,
0.1472313404083252,
0.11165434122085571,
0.2276393175125122,
-0.2850796580314636,
-0.21203890442848206,
-0.3850603997707367,
-0.0790984034538269,
0.1766999363899231,
-0.07965315878391266,
-0.08577345311641693,
0.25848138332366943,
-0.015095563605427742,
-0.19424216449260712,
0.07661682367324829,
-0.08939710259437561,
0.5258725881576538,
0.13892699778079987,
-0.21896468102931976,
-0.33542168140411377,
0.5101572275161743,
0.19794993102550507,
0.09910482913255692,
-0.33595746755599976,
0.2773952782154083,
-0.1462511420249939,
0.5109506249427795,
-0.06694873422384262,
-0.06833288073539734,
-0.10936153680086136,
-0.685605525970459,
-0.09385337680578232,
0.5940325856208801,
-0.40637996792793274,
0.05195203423500061,
0.7060829401016235,
-0.4338182508945465,
0.029271921142935753,
0.04321427270770073,
-0.006357142236083746,
-0.7079651355743408,
0.08593778312206268,
-0.08640800416469574,
0.31678998470306396,
0.018760737031698227,
-0.3637242317199707,
-0.17163321375846863,
0.04398774728178978,
-0.3145718276500702,
0.36652204394340515,
-0.033602043986320496,
-0.024959450587630272,
0.5801257491111755,
0.0964592844247818,
0.058085840195417404,
-0.09848001599311829,
0.9444835186004639,
0.6473799347877502,
-0.14255103468894958,
0.01730620674788952,
0.7322269082069397,
0.15194638073444366,
0.5056876540184021,
0.40374526381492615,
0.22854769229888916,
0.4778066575527191,
0.25045913457870483,
0.3119940459728241,
-0.5483852624893188,
-0.03652936592698097,
-0.6800488233566284,
0.1217755600810051,
0.19564244151115417,
-0.2948771119117737,
0.18107043206691742,
0.8764165639877319,
-0.8797045946121216,
0.22342117130756378,
0.1359354704618454,
-0.10398747026920319,
0.06157614663243294,
0.8057787418365479,
-0.40982186794281006,
-0.2672868072986603,
-0.05327080190181732,
0.4275241792201996,
-0.038794491440057755,
-0.12306911498308182,
0.2160177081823349,
-0.29171302914619446,
0.18621599674224854,
-0.15456008911132812,
-0.24639661610126495,
0.0753580704331398,
0.4189493954181671,
-0.2143978625535965,
0.219119593501091,
-0.1270589530467987,
0.4882611930370331,
-0.31500244140625,
0.20854781568050385,
0.22203828394412994,
-0.40408846735954285,
-0.44315773248672485,
0.17803479731082916,
0.6532007455825806,
-0.18349634110927582,
0.2112482786178589,
-0.2873922288417816,
-0.03407344967126846,
0.298263281583786,
0.45691272616386414,
0.08189033716917038,
-0.20054002106189728,
-0.18353213369846344,
-0.31567856669425964,
0.05066169053316116,
0.5599629282951355,
-0.34119927883148193,
0.25432953238487244,
0.3160422742366791,
-0.24830585718154907,
0.3346558213233948,
-0.11375190317630768,
-0.06788486242294312,
-0.0426967516541481,
-0.46768131852149963,
0.737942099571228,
0.12573201954364777,
-1.0126748085021973,
-0.009515177458524704,
0.05659832805395126,
-0.8266003131866455,
-0.18779714405536652,
-0.7753306031227112,
0.21032509207725525,
0.10417164862155914,
0.05381926894187927,
-0.41818803548812866,
0.20276173949241638,
-0.436516672372818,
0.14320412278175354,
-0.06451944261789322,
-0.5973933339118958,
0.10759395360946655,
-0.3170996904373169,
-0.08778106421232224,
0.29157137870788574,
-0.11914633959531784,
-0.1836908906698227,
0.25897839665412903,
0.754092812538147,
0.005913540720939636,
0.030793357640504837,
-0.19692450761795044,
0.07232934236526489,
-0.7347730398178101,
0.23816019296646118,
0.16085419058799744,
0.4870113432407379,
-0.04596387594938278,
0.20373424887657166,
-0.05896143242716789,
0.3649226129055023,
0.18532218039035797,
-0.3055296838283539,
-0.2502090334892273,
-0.3445805609226227,
0.07007116079330444,
-0.32564491033554077,
0.4768576920032501,
0.06215096637606621,
-0.06313883513212204,
-0.1930466890335083,
-0.20962391793727875,
-0.45230692625045776,
-0.4507741928100586,
-0.09955691546201706,
-0.7670958042144775,
-0.2818153500556946,
0.4360966086387634,
-0.13629336655139923,
0.1512620449066162,
0.11214632540941238,
-0.2707722783088684,
-0.5848764777183533,
0.2910529375076294,
0.5331745743751526,
-0.07576637715101242,
0.10561854392290115,
0.1065816804766655,
-0.5146583318710327,
0.09211474657058716,
0.38028663396835327,
-0.7135962247848511,
0.28192681074142456,
-0.195342555642128,
-0.521148681640625,
0.18033142387866974,
0.12031611055135727,
0.05891816318035126,
-0.6723713874816895,
-0.2554584741592407,
-0.2850385010242462,
-0.13748188316822052,
-0.05373089760541916,
0.3880384862422943,
-0.30646011233329773,
0.3017692267894745,
-0.1771615445613861,
-0.41375625133514404,
0.11704933643341064,
0.034831687808036804,
-0.06378214061260223,
-0.5939807295799255,
-0.2556392550468445,
0.36266252398490906,
0.5519075393676758,
0.03295149281620979,
0.08945707231760025,
0.026748793199658394,
0.5008881688117981,
-0.1187187060713768,
-0.2717466950416565,
-0.5915027856826782,
-0.47221270203590393,
0.07354337722063065,
0.014478501863777637,
-0.3990253508090973,
0.20990446209907532,
-0.24515195190906525,
-0.3351760506629944,
-0.013699795119464397,
0.2063409388065338,
-0.3744513690471649,
0.40289559960365295,
-0.5265895128250122,
-0.11784981191158295,
-0.3385050296783447,
0.4613538384437561,
0.46276506781578064,
0.00815279595553875,
0.16890855133533478,
-0.2625449597835541,
-0.17255015671253204,
0.1243416890501976,
0.18789950013160706,
-0.2276086062192917,
-0.4299628734588623,
0.22254648804664612,
-0.43410077691078186,
0.17907586693763733,
-0.6113392114639282,
0.3784058392047882,
0.0297495536506176,
-0.47091683745384216,
-0.024829531088471413,
-0.15825484693050385,
0.296330988407135,
-0.42075008153915405,
-0.539638876914978,
-0.31651124358177185,
-0.004998890683054924,
0.15894782543182373,
0.30184635519981384,
-0.1611253172159195,
-0.28506696224212646,
-0.4318070113658905,
0.3846227526664734,
0.4521273076534271,
-0.02906867116689682,
-0.34527871012687683,
0.06231912225484848,
0.18222391605377197,
-0.21439479291439056,
-0.3741114139556885,
-0.42564260959625244,
-0.06295782327651978,
-0.3178134560585022,
-0.01525288075208664,
0.4747633934020996,
-0.34943777322769165,
0.17855755984783173,
-0.12489259988069534,
-0.09716382622718811,
0.26493051648139954,
0.7219055891036987,
0.2676204741001129,
0.8661956787109375,
0.6882181763648987,
-0.18532288074493408,
0.0747450739145279,
0.4502982795238495,
0.21719084680080414,
0.27614691853523254,
-0.12255930155515671,
0.3900024890899658,
0.5490277409553528,
0.016570713371038437,
0.19851329922676086,
0.43514198064804077,
0.5387912392616272,
0.14944811165332794,
0.2995981276035309,
-0.6723712086677551,
-0.1076740026473999,
-0.16620337963104248,
0.6576282382011414,
0.8406111598014832,
-0.23159269988536835,
-0.4043869078159332,
0.3932245373725891,
-0.09264314919710159,
-0.1574482023715973,
0.3207327723503113,
-0.08700437843799591,
0.162411168217659,
-0.131326824426651,
-0.003718938445672393,
-0.4078946113586426,
-0.18624643981456757,
-0.4164941608905792,
0.5032005906105042,
-0.047972798347473145,
-0.05241953954100609,
-0.7360697388648987,
0.6512307524681091,
0.040446680039167404,
0.2802921533584595,
-0.1026979386806488,
0.5277935862541199,
-0.496845543384552,
-0.23932985961437225,
0.02081150747835636,
0.21218521893024445,
0.10669965296983719,
0.11572974175214767,
0.061391763389110565,
0.013735216110944748,
-0.15804840624332428,
0.5012747049331665,
0.2806279957294464,
-0.3911283016204834,
0.26731011271476746,
0.06100030988454819,
-0.027440372854471207,
0.4786640405654907,
-0.27589285373687744,
0.1322176456451416,
-0.21985656023025513,
-0.29786214232444763,
0.058136239647865295,
-0.09751375764608383,
-0.3024837076663971,
0.32869860529899597,
-0.022040577605366707,
0.04716603457927704,
-0.33904150128364563,
-0.3679788112640381,
0.41630253195762634,
0.2224237471818924,
0.11471349000930786,
-0.20095381140708923,
-0.35515862703323364,
0.0943007543683052,
0.4681234657764435,
0.33503857254981995,
0.1550646871328354,
0.10688839107751846,
0.1166045293211937,
0.17971612513065338,
-0.1616029590368271,
0.42902058362960815,
-0.4741743505001068,
-0.050319720059633255,
-0.5456392168998718,
-0.18435007333755493,
0.503166913986206,
0.7391334176063538,
-0.35395506024360657,
0.1501701921224594,
0.2370585799217224,
-0.2534366548061371,
0.3895620107650757,
-0.5566007494926453,
-0.2735423445701599,
-0.5964273810386658,
-0.06123067066073418,
-0.8318914175033569,
0.41854095458984375,
-0.1633496880531311,
-0.40685635805130005,
-0.1225593239068985,
0.5395940542221069,
0.24373455345630646,
0.1933797150850296,
0.18957871198654175,
-0.2844240069389343,
-0.3896913528442383,
-0.5008211135864258,
0.3781172037124634,
-0.7649141550064087,
0.31001174449920654,
-0.32083478569984436,
0.2795751690864563,
-0.089691661298275,
-0.22421975433826447,
0.15733802318572998,
-0.2590430974960327,
-0.1003948450088501,
-0.2602219581604004,
0.1459319293498993,
0.43328362703323364,
-0.4285893738269806,
-0.5287379622459412,
-0.564741313457489,
0.11475101858377457,
-0.15738710761070251,
-0.8609572649002075,
0.02409239485859871,
-0.13699392974376678,
-0.13921725749969482,
-0.14099939167499542,
0.2483488768339157,
-0.19445863366127014,
-0.2776791453361511,
-0.4834462106227875
] |
Blood pressure variability is one of the characteristic features of hypertension in the elderly. However, its clinical significance remains to be determined. We therefore examined the impact of blood pressure variability on the development of cardiovascular events in elderly hypertensive patients. A total of 106 consecutive hypertensive patients aged more than 60 years old (mean age, 73.9 +/- 8.1 years old; male, 54%), all of whom underwent 24-h ambulatory blood pressure monitoring, were followed up (median, 34 months; range, 3-60 months). During the follow-up period, 39 cardiovascular events were observed, including 14 cases of cerebral infarction and 7 cases of acute myocardial infarction. The coefficient of variation (CV) of 24-h systolic blood pressure (SBP) values was used as an index of blood pressure variability. The patients showed a mean CV value of 10.6%, and were divided into two groups according to this mean value as a cut-off point: a high CV group (n = 46) and a low CV group (n = 60). Although baseline clinical characteristics were similar in the two groups, Kaplan-Meier plots for event-free survival revealed that the rate of cardiovascular events was significantly higher in high CV group than in low CV group (p < 0.05). Cox's proportional hazards analysis showed that increased blood pressure variability (a high CV value of 24-h SBP) was an independent predictive variable for cardiovascular events. The CV value of daytime SBP and the SD value of both 24-h SBP and daytime SBP also had positive correlations with the onset of cardiovascular events. These results suggest that increased blood pressure variability may be an independent risk factor for cardiovascular events in elderly hypertensive patients. | [
-0.014696195721626282,
0.01587873324751854,
-0.027721267193555832,
0.02012711949646473,
0.006182936951518059,
0.015287572517991066,
0.009628452360630035,
0.002667759545147419,
-0.010883798822760582,
-0.000945663545280695,
0.008019013330340385,
0.022090576589107513,
-0.0032615961972624063,
0.011005968786776066,
0.020399179309606552,
0.0013182206312194467,
-0.021548960357904434,
0.009932774119079113,
0.006762392353266478,
0.00030095595866441727,
0.014207042753696442,
0.0024303277023136616,
0.009660429321229458,
-0.002239260356873274,
-0.011442333459854126,
0.012833097018301487,
0.03752836585044861,
-0.0032621079590171576,
0.011902639642357826,
-0.015103748068213463,
-0.000641311053186655,
-0.007002970203757286,
-0.011784427799284458,
0.02524459734559059,
0.001039913040585816,
-0.03644783794879913,
0.007250583730638027,
0.008304868824779987,
0.0008734297007322311,
-0.005067931488156319,
0.004443410784006119,
-0.007906435057520866,
-0.00009211705764755607,
-0.006861778907477856,
-0.005601782817393541,
0.013579885475337505,
-0.00648917444050312,
0.0022308598272502422,
-0.008457610383629799,
0.013983359560370445,
-0.01443072035908699,
-0.014883363619446754,
-0.006214425433427095,
-0.010353638790547848,
-0.00564156100153923,
0.005397215485572815,
0.01938994601368904,
0.0015063779428601265,
-0.022060751914978027,
-0.01185001153498888,
-0.02090619131922722,
0.015490276739001274,
-0.0035937591455876827,
0.0141240693628788,
-0.020515579730272293,
-0.06730914115905762,
-0.014186915010213852,
-0.00512013491243124,
0.0018137965817004442,
0.0036411802284419537,
-0.00018136575818061829,
0.006538516841828823,
0.008236993104219437,
0.012375249527394772,
0.002193594817072153,
0.008481697179377079,
-0.0065467506647109985,
-0.02371753193438053,
0.012914552353322506,
-0.001084587536752224,
-0.012338900938630104,
0.008772196248173714,
-0.0020636231638491154,
0.012288978323340416,
-0.007922112941741943,
0.00977571215480566,
0.004242663271725178,
-0.0066441940143704414,
0.0003330174367874861,
-0.009859656915068626,
0.006510305684059858,
0.002030632458627224,
-0.01579144224524498,
-0.012628117576241493,
-0.004505403805524111,
-0.003510975046083331,
-0.02276531793177128,
-0.003490892704576254,
-0.002998130163177848,
-0.013461561873555183,
-0.0162394717335701,
-0.007924753241240978,
0.015357102267444134,
-0.0030223941430449486,
-0.029458560049533844,
0.003983650356531143,
0.005505686160176992,
-0.002680803183466196,
0.014164036139845848,
0.0042642224580049515,
-0.00040828692726790905,
0.019161975011229515,
0.027415167540311813,
-0.001876210793852806,
0.012872694060206413,
0.0394337922334671,
0.011553349904716015,
-0.008514170534908772,
0.0017906964058056474,
-0.016191137954592705,
-0.01599889062345028,
-0.02603061869740486,
-0.007772453129291534,
-0.0033004889264702797,
-0.006646334193646908,
0.007673628628253937,
0.01258894708007574,
-0.014807449653744698,
-0.015119217336177826,
-0.004163182806223631,
-0.0014200989389792085,
-0.007032425608485937,
-0.0192442387342453,
0.010011148639023304,
-0.006127883214503527,
-0.0015171437989920378,
-0.015164889395236969,
0.014979622326791286,
-0.0037235417403280735,
-0.006362438667565584,
-0.012149984017014503,
0.01002440694719553,
-0.0017873907927423716,
0.0014621044974774122,
-0.009856734424829483,
-0.014318381436169147,
0.011656787246465683,
0.014595938846468925,
0.026406485587358475,
-0.021983861923217773,
-0.005075238645076752,
-0.040161170065402985,
-0.014294812455773354,
-0.03942692279815674,
-0.005349279381334782,
-0.0021145734935998917,
-0.0034380655270069838,
0.006918116472661495,
0.007686767727136612,
0.0068418122828006744,
0.007400426082313061,
0.001562346238642931,
0.033078182488679886,
0.010326857678592205,
0.009848655201494694,
0.009457111358642578,
0.03125128522515297,
-0.016862213611602783,
0.00034940592013299465,
0.005303415469825268,
-0.0068250661715865135,
0.02902686595916748,
-0.011010819114744663,
0.01660103164613247,
0.01229516789317131,
-0.008810563012957573,
-0.001249727443791926,
0.0073146335780620575,
0.0025377857964485884,
0.06723661720752716,
-0.01737675815820694,
0.005318047478795052,
-0.024790555238723755,
0.006165879778563976,
0.012252382934093475,
-0.022276993840932846,
0.018514201045036316,
-0.012934919446706772,
0.018202435225248337,
-0.006687948480248451,
0.027520762756466866,
-0.012984172441065311,
0.03170895576477051,
0.0094049833714962,
0.005959273315966129,
0.004838481079787016,
0.01018860749900341,
0.006989361718297005,
-0.01987408846616745,
-0.0044164229184389114,
0.0002685384824872017,
-0.006977517157793045,
0.01049091387540102,
0.0014286162331700325,
0.002106272615492344,
0.008673157542943954,
0.026934875175356865,
-0.0014659904409199953,
-0.009153402410447598,
0.01792134903371334,
0.026035958901047707,
0.026406383141875267,
-0.006515990011394024,
-0.007848164066672325,
0.01176242996007204,
-0.01085461676120758,
0.004269124008715153,
-0.00009516719728708267,
-0.01935221068561077,
-0.019871968775987625,
0.012884162366390228,
-0.004828263074159622,
0.017187416553497314,
-0.007776190992444754,
0.006186069920659065,
-0.006154724396765232,
0.0028264434076845646,
0.006895659491419792,
0.008597075939178467,
0.021227682009339333,
-0.00570750143378973,
-0.024730369448661804,
-0.008439246565103531,
0.004122940357774496,
0.007514497265219688,
0.011399604380130768,
0.01466374471783638,
-0.017610078677535057,
0.02485380321741104,
-0.021910410374403,
-0.017703987658023834,
-0.015374692156910896,
0.02161707542836666,
-0.006179938558489084,
0.01630159467458725,
-0.020818252116441727,
-0.002221789676696062,
-0.0017245450289919972,
0.012333567254245281,
-0.02781110256910324,
0.008719605393707752,
0.018223725259304047,
-0.011810691095888615,
-0.0060037365183234215,
0.0064650848507881165,
0.00193678995128721,
-0.02116626873612404,
-0.008600922301411629,
0.025008220225572586,
-0.008524217642843723,
0.019933350384235382,
0.0076960232108831406,
-0.002544477116316557,
0.004176143556833267,
-0.009939717128872871,
-0.018627705052495003,
-0.005400166846811771,
0.030806496739387512,
-0.017158880829811096,
-0.019803695380687714,
0.00799697544425726,
-0.010440203361213207,
-0.014043857343494892,
-0.08149746060371399,
-0.010104421526193619,
-0.00664706714451313,
-0.005883664358407259,
0.0011640149168670177,
-0.010787097737193108,
0.03229117393493652,
0.015449839644134045,
0.0035754526033997536,
0.001777965109795332,
-0.010102396830916405,
-0.010960469022393227,
-0.0005545657477341592,
0.027717944234609604,
-0.008644399233162403,
0.0031880992464721203,
-0.0028714430518448353,
0.002615144941955805,
-0.021655738353729248,
-0.0051019685342907906,
0.01660224422812462,
-0.002698018215596676,
-0.0016191024333238602,
0.0044190362095832825,
0.009031166322529316,
0.00016434583812952042,
0.016781222075223923,
-0.011060254648327827,
-0.007080326322466135,
0.020326459780335426,
0.011322257108986378,
-0.01810719072818756,
-0.0018822276033461094,
0.00432689068838954,
-0.03690579533576965,
-0.006850105710327625,
-0.016376368701457977,
0.01474463939666748,
-0.0024472358636558056,
-0.006130661349743605,
0.0026742552872747183,
0.012507867068052292,
-0.015486713498830795,
-0.013134866952896118,
-0.005539909470826387,
0.00203061755746603,
0.03322913497686386,
0.011332059279084206,
0.018075166270136833,
-0.01636671833693981,
0.016145406290888786,
-0.011164759285748005,
0.03225139528512955,
0.009617500007152557,
-0.023811671882867813,
-0.0072198715060949326,
0.025056850165128708,
0.0032537709921598434,
-0.009442400187253952,
-0.016565576195716858,
-0.02417609840631485,
0.009036894887685776,
-0.0024524186737835407,
0.002212135586887598,
0.0002494058571755886,
0.016306886449456215,
-0.0010841893963515759,
-0.021907508373260498,
-0.012929265387356281,
0.022535154595971107,
0.007478426676243544,
-0.006498213857412338,
0.013160952366888523,
-0.019560739398002625,
-0.004618913866579533,
0.00134280975908041,
-0.018746698275208473,
0.007732142694294453,
0.00931170117110014,
0.006358841899782419,
-0.03252505138516426,
-0.00524185411632061,
0.0042219823226332664,
0.003232560120522976,
-0.008154001086950302,
0.0023136320523917675,
0.017805874347686768,
0.03635372221469879,
0.01822352036833763,
-0.008596247993409634,
-0.0034931020345538855,
0.048289790749549866,
0.011553238146007061,
0.0085112564265728,
0.02669578045606613,
-0.02144058793783188,
-0.006351850461214781,
-0.007078926544636488,
-0.0022744755260646343,
0.008218934759497643,
-0.016084544360637665,
-0.006530263926833868,
-0.0010431832633912563,
-0.01409372128546238,
-0.011132004670798779,
0.007888918742537498,
0.00538230873644352,
-0.015199143439531326,
0.016895972192287445,
-0.0044984109699726105,
-0.032757263630628586,
-0.014294936321675777,
-0.009484946727752686,
0.006541264243423939,
0.015887470915913582,
0.0174300204962492,
0.017595620825886726,
0.0016519464552402496,
0.071980781853199,
-0.01346544735133648,
0.006957069505006075,
-0.011491328477859497,
-0.010680703446269035,
-0.0200352743268013,
-0.030974555760622025,
0.0010875128209590912,
-0.009260021150112152,
-0.032945066690444946,
0.013030309230089188,
0.01030788104981184,
0.003377187065780163,
-0.049875739961862564,
0.00006789574399590492,
-0.004402513615787029,
-0.010179020464420319,
-0.019201718270778656,
-0.01805521361529827,
-0.015103310346603394,
-0.008891403675079346,
0.017171017825603485,
-0.0236952006816864,
-0.01770857535302639,
0.022708259522914886,
-0.01909520849585533,
-0.03050854802131653,
-0.016087591648101807,
-0.008558442816138268,
0.009061276912689209,
0.002529781311750412,
0.01619049906730652,
-0.005283243954181671,
-0.012055231258273125,
0.008993418887257576,
-0.016723502427339554,
-0.019953474402427673,
0.015192183665931225,
0.017352594062685966,
-0.003280906705185771,
-0.052697211503982544,
-0.00955259334295988,
-0.024173326790332794,
0.0031111077405512333,
-0.0001497780904173851,
0.013365281745791435,
-0.017586559057235718,
-0.003638490103185177,
-0.00554956030100584,
0.007615005597472191,
-0.004702696576714516,
0.0012555081630125642,
0.016508158296346664,
0.015914952382445335,
-0.021151535212993622,
0.021692432463169098,
-0.003316150978207588,
-0.011997808702290058,
-0.028327979147434235,
-0.013389328494668007,
-0.0010918066836893559,
-0.025723867118358612,
-0.03468643128871918,
-0.029230589047074318,
-0.027058644220232964,
-0.004763134755194187,
0.03890782594680786,
0.00440663006156683,
-0.027584165334701538,
0.006427633110433817,
0.004147077910602093,
0.0060257334262132645,
-0.009994369000196457,
-0.019040841609239578,
-0.007791331969201565,
-0.015689417719841003,
-0.007714659441262484,
-0.020886501297354698,
0.036220986396074295,
-0.008664742112159729,
-0.0008700491162016988,
0.03793460503220558,
0.025035785511136055,
-0.03033125214278698,
0.019270513206720352,
0.03289768844842911,
-0.03180476278066635,
-0.07485628128051758,
-0.022621579468250275,
0.03326273337006569,
-0.015993406996130943,
-0.024519912898540497,
0.018015630543231964,
-0.027227293699979782,
0.00703092385083437,
-0.015861593186855316,
-0.01029850821942091,
0.005337704438716173,
0.02004016563296318,
0.021768754348158836,
-0.004011133220046759,
0.01826670952141285,
0.014798243530094624,
-0.015523205511271954,
0.003844957333058119,
-0.010474191047251225,
0.007078590802848339,
-0.0018317727372050285,
0.06179285794496536,
-0.031011244282126427,
-0.008036927320063114,
0.006109694018959999,
-0.08110103011131287,
-0.006375717930495739,
-0.012810645624995232,
0.000009023118764162064,
-0.010275393724441528,
0.022703370079398155,
0.010928099043667316,
-0.011991603299975395,
-0.022472886368632317,
-0.013607709668576717,
0.022624686360359192,
-0.012713831849396229,
0.027207477018237114,
-0.013813463039696217,
0.01149816531687975,
-0.0075391121208667755,
0.017965415492653847,
-0.006529493257403374,
-0.0065107098780572414,
0.04301311820745468,
0.010230309329926968,
0.025587845593690872,
-0.0026963846758008003,
0.044219970703125,
-0.003650406841188669,
-0.043806180357933044,
-0.012090139091014862,
0.006799658760428429,
0.008185849525034428,
-0.022035596892237663,
-0.012293947860598564,
0.000833420199342072,
-0.02380562201142311,
0.004279496148228645,
0.004900968633592129,
-0.013473866507411003,
0.03223183751106262,
-0.002576792147010565,
-0.02907029539346695,
0.0004885704256594181,
0.0016984003596007824,
0.003633186686784029,
0.025154348462820053,
-0.026594961062073708,
0.006652597337961197,
-0.012707623653113842,
0.008437948301434517,
-0.013792000710964203,
0.002087918110191822,
0.018567653372883797,
0.012851007282733917,
0.016318798065185547,
-0.00467232521623373,
0.004085533320903778,
-0.04600800201296806,
-0.0036344369873404503,
-0.006191125139594078,
0.011572465300559998,
-0.0076959459111094475,
0.01107807457447052,
-0.006065417546778917,
-0.012076816521584988,
-0.0012915786355733871,
0.07219970226287842,
-0.03319036215543747,
-0.010948825627565384,
-0.024835001677274704,
-0.0009108070516958833,
0.002847525291144848,
-0.001360895112156868,
-0.030652666464447975,
0.0032360348850488663,
-0.0006490997038781643,
0.014509690925478935,
0.0009226046968251467,
-0.01862718164920807,
0.008426057174801826,
-0.00011882348917424679,
0.005407167598605156,
0.023514557629823685,
0.02006031759083271,
-0.052760642021894455,
-0.0038542873226106167,
-0.01713673584163189,
0.022666694596409798,
-0.037149541079998016,
-0.004633766133338213,
-0.008412832394242287,
0.004106085281819105,
0.01642277091741562,
-0.00841786339879036,
-0.008131791837513447,
-0.003693758277222514,
-0.018792983144521713,
-0.02344389259815216,
0.013516373001039028,
0.01333573367446661,
0.019580790773034096,
-0.005793060641735792,
0.0003248236607760191,
0.007956965826451778,
0.010057169944047928,
0.00203798059374094,
0.032935116440057755,
-0.003777401987463236,
0.004777703434228897,
-0.016703955829143524,
0.01476462371647358,
-0.028879450634121895,
0.012370044365525246,
0.009958751499652863,
0.009197182953357697,
0.015436835587024689,
-0.021761037409305573,
0.008844653144478798,
0.007424567826092243,
-0.04386633634567261,
0.012193670496344566,
-0.015591619536280632,
-0.007549795787781477,
0.021303482353687286,
0.010179429315030575,
-0.003972528502345085,
-0.0013517444021999836,
-0.007518664468079805,
0.025859195739030838,
-0.010708599351346493,
-0.0036651070695370436,
0.0011941177072003484,
0.008963161148130894,
-0.0065381452441215515,
0.013254982419312,
0.007551257032901049,
0.011656315997242928,
0.018259236589074135,
0.008763723075389862,
0.009259641170501709,
-0.0029269566293805838,
-0.00900453981012106,
0.01765282079577446,
0.02910846844315529,
0.0021385205909609795,
0.02427634969353676,
-0.006471614353358746,
-0.04474393278360367,
0.009580465033650398,
0.0042522987350821495,
0.027681615203619003,
-0.012341766618192196,
0.02205757051706314,
0.022166654467582703,
-0.012586086057126522,
-0.0003627802070695907,
0.002208071295171976,
0.0018429221818223596,
-0.0047323983162641525,
0.003022451652213931,
0.007853120565414429,
0.035045474767684937,
0.011302236467599869,
-0.001311751315370202,
0.022990889847278595,
-0.00834316574037075,
0.014695797115564346,
0.0014079692773520947,
-0.014996806159615517,
0.020057812333106995,
0.016260726377367973,
0.002927730791270733,
0.004709758795797825,
0.021456938236951828,
0.009378613904118538,
0.00969130638986826,
-0.022638259455561638,
0.003062433796003461,
0.033410098403692245,
0.004483746364712715,
-0.009100360795855522,
0.04517337679862976,
-0.006889579817652702,
-0.0017690436216071248,
0.007795112207531929,
-0.011595066636800766,
0.012690612114965916,
0.015838677063584328,
-0.011688894592225552,
-0.00926225446164608,
0.007205761969089508,
0.009457264095544815,
-0.0022899387404322624,
-0.0009056006092578173,
0.016269925981760025,
0.015381609089672565,
0.020076841115951538,
-0.021455232053995132,
0.015650667250156403,
0.004860944114625454,
-0.0018496009288355708,
-0.04215001314878464,
-0.002082801889628172,
0.003972695209085941,
-0.043832167983055115,
-0.005557467229664326,
0.03132053092122078,
-0.0027653519064188004,
0.0045778788626194,
-0.014588624238967896,
0.008906382136046886,
-0.006868692114949226,
-0.025515131652355194,
0.01762789487838745,
0.01382548175752163,
0.004113428294658661,
-0.005137683358043432,
0.00142956105992198,
0.0031257637310773134,
-0.0036013550125062466,
0.03644731640815735,
-0.0007339536678045988,
0.0055525582283735275,
-0.012195039540529251,
-0.011386636644601822,
-0.01684795320034027,
-0.0019251034827902913,
-0.02843601256608963,
0.01939256116747856,
-0.001663397066295147,
-0.006834031082689762,
0.003811197355389595,
0.03402139991521835,
0.0054407427087426186,
-0.013850534334778786,
-0.005474874749779701,
0.014869257807731628,
0.012779873795807362,
0.006663620471954346,
-0.0019716774113476276,
-0.013277117162942886,
-0.0022222762927412987,
-0.006488331593573093,
0.0033072391524910927,
0.009088734164834023,
0.014180297963321209,
0.00985427014529705,
-0.009961203671991825,
-0.0016148454742506146,
-0.014677510596811771,
0.004337022081017494,
-0.0009298003278672695,
-0.01470533013343811,
0.002790597965940833,
0.014027854427695274,
0.019329089671373367,
-0.049166418612003326,
-0.00507856160402298,
-0.0050131091848015785,
0.0017897600773721933,
-0.008855754509568214,
0.02456272952258587,
0.015138108283281326,
0.015581643208861351,
-0.005319871008396149,
-0.001729442155919969,
0.010381821542978287,
-0.0030046869069337845
] | [
0.06348590552806854,
-0.03760632500052452,
0.7823919653892517,
-0.02474363148212433,
0.10208968818187714,
0.5691797733306885,
0.4037359058856964,
0.011060967110097408,
-0.1472674459218979,
-0.35559114813804626,
0.2904098927974701,
0.283203125,
-0.1347813904285431,
0.137856587767601,
0.10711507499217987,
0.4696582555770874,
0.4691471755504608,
0.5253650546073914,
0.04029611870646477,
-0.7996061444282532,
-0.3946327865123749,
-0.3271341025829315,
0.8097983598709106,
-0.03145257383584976,
-0.40353816747665405,
-0.05667812377214432,
0.2899109125137329,
-0.5523583292961121,
-0.08965939283370972,
0.1637614220380783,
-0.08620504289865494,
1.1496232748031616,
0.05719625949859619,
-0.1556750386953354,
0.17392654716968536,
0.36049631237983704,
0.29726383090019226,
-0.07975799590349197,
0.2898659408092499,
-0.21459753811359406,
-0.2814570367336273,
-0.5289844274520874,
-0.018166417255997658,
0.17442506551742554,
-0.20538505911827087,
-0.06757020950317383,
-1.1981974840164185,
0.3279382884502411,
-0.02419162541627884,
-0.2463047206401825,
0.07295549660921097,
0.36370229721069336,
0.8962430357933044,
0.03173734247684479,
-0.23456227779388428,
0.2912653982639313,
-0.5456508994102478,
-0.24910634756088257,
-0.028577065095305443,
-0.21754969656467438,
0.9266107678413391,
-0.2167249321937561,
-0.08647999167442322,
-0.07082992047071457,
-0.16370199620723724,
-0.09293615818023682,
0.15433275699615479,
0.2403125762939453,
-0.09550004452466965,
0.24083878099918365,
0.25014907121658325,
-0.030325355008244514,
-0.023773811757564545,
-0.23656857013702393,
-0.3727821707725525,
0.4798608124256134,
-0.4351083040237427,
-0.012140565551817417,
0.2812305688858032,
-0.5057649612426758,
0.5931026339530945,
-0.3971998989582062,
0.616923451423645,
0.11253522336483002,
0.10484675318002701,
0.052479326725006104,
0.2605997920036316,
0.15685516595840454,
0.17420700192451477,
0.1407710760831833,
-0.636314868927002,
-0.23655855655670166,
0.6337224841117859,
0.41265785694122314,
-0.11900786310434341,
0.3685548007488251,
0.18897153437137604,
-0.07344651967287064,
0.11799889802932739,
-0.36275434494018555,
0.27221959829330444,
-0.3482663631439209,
-0.12773072719573975,
-0.35531851649284363,
-0.45868372917175293,
-0.25240358710289,
-0.013600596226751804,
-0.3173539340496063,
0.23314952850341797,
0.013342834077775478,
-1.109120488166809,
0.007467719726264477,
-0.04798709228634834,
-0.18029096722602844,
-0.30117738246917725,
0.1784488409757614,
0.048589449375867844,
-0.1345379650592804,
0.42992252111434937,
0.03524694964289665,
-0.4531426727771759,
-0.20006145536899567,
-0.08566561341285706,
-0.18810759484767914,
-0.15024146437644958,
0.5244228839874268,
0.7813940644264221,
0.010914362035691738,
0.14025761187076569,
0.022219723090529442,
0.22136174142360687,
0.4577968120574951,
-0.057761646807193756,
0.10759705305099487,
0.44987550377845764,
-0.227909654378891,
-0.03020484372973442,
0.07528051733970642,
0.4385574162006378,
0.35805001854896545,
0.3852393925189972,
-0.4912213683128357,
-0.6396313905715942,
-0.2475518435239792,
0.2589103579521179,
0.4334438741207123,
0.026126166805624962,
0.07246892899274826,
-0.35618141293525696,
-0.18006515502929688,
-0.027000362053513527,
0.3203756809234619,
-0.2908148467540741,
-0.26874440908432007,
0.4118981957435608,
-0.09454693645238876,
-0.6680359840393066,
-0.4156903624534607,
-0.0039681605994701385,
-0.2053299844264984,
0.3288480341434479,
0.4392334520816803,
-0.22318540513515472,
0.37085896730422974,
0.6118158102035522,
-0.041800592094659805,
0.13829177618026733,
0.4287310242652893,
-0.7082715630531311,
0.25061672925949097,
-0.15734468400478363,
0.19533434510231018,
0.16870231926441193,
-0.3610497713088989,
-0.3889569044113159,
0.5110413432121277,
0.6018592119216919,
0.44384169578552246,
0.20060744881629944,
-0.27698054909706116,
-0.594235897064209,
0.531343936920166,
0.37910836935043335,
0.047324370592832565,
0.5017050504684448,
0.283958375453949,
0.18312858045101166,
0.1549808233976364,
0.24792036414146423,
-0.05409665405750275,
0.5125159621238708,
-0.22200562059879303,
0.35857611894607544,
-0.7191887497901917,
0.8692681789398193,
-0.4198605418205261,
0.38433730602264404,
0.799827516078949,
0.1254320740699768,
-0.1935218870639801,
0.23951685428619385,
0.22094228863716125,
0.929332971572876,
-0.1467457264661789,
-0.3953448534011841,
-0.12369511276483536,
-0.4498496353626251,
-0.2571159303188324,
0.01623137667775154,
0.06749053299427032,
0.270128458738327,
-0.23346807062625885,
-0.653934895992279,
0.16380675137043,
-0.29774340987205505,
0.12093468010425568,
0.15120257437229156,
0.025251489132642746,
-0.041401125490665436,
-0.15319545567035675,
0.5449401140213013,
-0.5004684925079346,
0.37335002422332764,
0.3707368075847626,
-0.1282086968421936,
0.06159885972738266,
0.648441731929779,
0.06804722547531128,
0.6461271047592163,
-0.7454118132591248,
0.016395485028624535,
-0.3848598599433899,
0.2535802721977234,
0.09664271026849747,
0.2564537525177002,
0.3469168245792389,
-0.09475711733102798,
-0.194014310836792,
0.011731353588402271,
0.14329209923744202,
-0.14480343461036682,
0.5022904872894287,
-0.4216344356536865,
0.56028813123703,
0.1288958340883255,
-0.34807726740837097,
-0.4105508029460907,
0.7801549434661865,
-1.0930705070495605,
-0.057929590344429016,
0.40803423523902893,
0.6718567609786987,
0.025098958984017372,
-0.18307244777679443,
0.10004425793886185,
-0.09716863185167313,
0.05114525184035301,
-0.23431283235549927,
-0.19107890129089355,
-0.42037099599838257,
0.25534510612487793,
0.09498506039381027,
0.7582536339759827,
0.047434817999601364,
0.12133832275867462,
-0.795015811920166,
-1.276796817779541,
-0.8970420956611633,
0.36119988560676575,
0.006380887236446142,
0.4201335310935974,
0.21472153067588806,
-0.3735976815223694,
0.3606986105442047,
0.14461100101470947,
-0.43455198407173157,
-0.4344482719898224,
0.6101072430610657,
-0.8443185687065125,
0.23288464546203613,
0.32504481077194214,
0.6593870520591736,
0.4589209258556366,
-0.022228503599762917,
-0.44491374492645264,
-0.024611400440335274,
-0.21488961577415466,
0.24356192350387573,
0.09084779769182205,
-0.6222692131996155,
-0.14383465051651,
0.32319730520248413,
0.11915824562311172,
-0.2315635085105896,
0.1314295381307602,
0.24641503393650055,
0.012381376698613167,
0.9932591915130615,
0.6467781662940979,
0.483662486076355,
0.17364272475242615,
0.04848528653383255,
0.1183856725692749,
-0.30893659591674805,
-0.45067065954208374,
0.02068377286195755,
-0.543856680393219,
0.12514960765838623,
-5.9156599044799805,
0.1453855335712433,
-0.47525742650032043,
-0.7036854028701782,
-0.17312049865722656,
-0.23206961154937744,
1.0527269840240479,
0.197191521525383,
-0.2377305030822754,
0.573880672454834,
0.4703778624534607,
0.29942527413368225,
0.20478667318820953,
0.5227327346801758,
-0.06065891310572624,
-0.057699453085660934,
0.3311018943786621,
-0.2579042911529541,
-0.10805797576904297,
0.13055187463760376,
0.3167142868041992,
-0.3485928475856781,
-0.12536583840847015,
0.41476547718048096,
0.5354936718940735,
0.38948526978492737,
-0.4838539958000183,
-0.06143185496330261,
-0.7279648780822754,
-0.1200023740530014,
-0.2234538495540619,
-0.6007526516914368,
-0.1629461795091629,
0.3317610025405884,
0.37834957242012024,
-0.040550775825977325,
0.15331383049488068,
0.17802280187606812,
0.2945220172405243,
-0.4563891887664795,
-0.07810468971729279,
-0.15192793309688568,
-0.3998313546180725,
0.0036855065263807774,
-0.2071860283613205,
0.5119147300720215,
0.25822609663009644,
0.08609675616025925,
-0.1093517616391182,
0.3094644248485565,
-0.18890275061130524,
-0.3885493576526642,
0.11553113162517548,
0.29234498739242554,
0.25860217213630676,
0.4113926887512207,
-0.5281068682670593,
0.3093079924583435,
-0.30775904655456543,
0.33572444319725037,
-0.23998555541038513,
0.01628027856349945,
-0.35063254833221436,
-0.6076648831367493,
-0.26901131868362427,
0.0749986544251442,
-1.1710448265075684,
-0.4409378468990326,
0.43061113357543945,
0.4657047390937805,
-0.2769826054573059,
0.1379740834236145,
0.1219884380698204,
-0.5316134691238403,
0.4340343177318573,
-0.8212531208992004,
0.6016713380813599,
0.49905914068222046,
-0.4124148190021515,
-0.6619765758514404,
-0.2924453914165497,
0.0073469700291752815,
-0.10179833322763443,
-0.06289370357990265,
0.5036516785621643,
-0.1282326728105545,
-0.0673443153500557,
-0.2080121636390686,
0.07661935687065125,
-0.22104763984680176,
0.42890387773513794,
-0.46376240253448486,
0.11032046377658844,
0.06770823150873184,
0.12096335738897324,
0.36693599820137024,
0.24653828144073486,
0.5054706931114197,
0.4857392907142639,
-0.3388804793357849,
0.559781014919281,
-0.3105701804161072,
-0.08203902095556259,
-0.7104506492614746,
-0.700286328792572,
0.40599575638771057,
-0.5470821857452393,
0.05960335582494736,
0.6118641495704651,
-0.5696431398391724,
0.20701812207698822,
-0.14932851493358612,
-0.07138343155384064,
-0.7581831812858582,
0.3866185247898102,
-0.21528446674346924,
-0.3909411132335663,
-0.11029119044542313,
0.5528772473335266,
0.3512267768383026,
0.46252843737602234,
0.038234464824199677,
-0.9192695021629333,
0.09924153983592987,
0.3998491168022156,
0.18559755384922028,
-0.021658997982740402,
0.24718543887138367,
-0.8069282174110413,
0.06579722464084625,
0.15159007906913757,
0.3180508315563202,
-0.17219263315200806,
0.3871719241142273,
0.19776883721351624,
-0.48984548449516296,
-0.1617305874824524,
0.24845650792121887,
0.38386666774749756,
0.1269124150276184,
0.2670878469944,
-0.13508647680282593,
-0.3595573306083679,
-0.12900149822235107,
-0.13110363483428955,
0.13414697349071503,
-0.2169201523065567,
-0.47775885462760925,
-0.45442309975624084,
0.20170798897743225,
0.27237454056739807,
-0.6524227857589722,
-0.15813720226287842,
0.11777828633785248,
-0.6040879487991333,
0.3619396686553955,
0.3246871531009674,
0.26794514060020447,
-0.2759759724140167,
-0.6638907790184021,
0.07528288662433624,
0.05704251676797867,
-1.0837815999984741,
-0.4835825264453888,
0.032034486532211304,
-0.042382948100566864,
-0.10984855890274048,
-0.014766334556043148,
0.1630195826292038,
0.6400980353355408,
0.1207585409283638,
-0.22325271368026733,
-0.37938904762268066,
-0.28605917096138,
0.32669755816459656,
-0.027324246242642403,
-0.6859819293022156,
0.20173673331737518,
-0.13199128210544586,
0.07319090515375137,
0.07668383419513702,
-0.030706102028489113,
-0.5639550685882568,
0.07894064486026764,
0.377653568983078,
0.5440481305122375,
0.1025751605629921,
0.09933479875326157,
-0.12401940673589706,
0.3498198986053467,
0.3042239546775818,
-0.07686266303062439,
0.2219681590795517,
-0.6473532915115356,
0.031496137380599976,
-0.30565932393074036,
-0.09069275110960007,
0.8266894817352295,
-0.25027886033058167,
0.40087470412254333,
0.1925947070121765,
0.19731657207012177,
-0.04952683299779892,
0.38024696707725525,
0.7373488545417786,
-0.08500617742538452,
-0.3152773976325989,
-0.39983975887298584,
-0.659787118434906,
-0.29816314578056335,
-0.5467898845672607,
-0.624513566493988,
-0.4443870186805725,
0.2732113003730774,
-0.2980613112449646,
0.22756624221801758,
-0.276276171207428,
-0.7761329412460327,
-0.16544456779956818,
0.2488788515329361,
0.011484411545097828,
0.20899461209774017,
-0.3833252489566803,
-0.09223877638578415,
-0.020128726959228516,
-0.4746309816837311,
0.35829347372055054,
-0.9386133551597595,
0.2575250267982483,
-0.012814314104616642,
-0.241510272026062,
-0.1299956887960434,
0.09480971843004227,
0.12505146861076355,
-0.5817375183105469,
-0.2768864631652832,
-0.280546635389328,
-0.04710770770907402,
-0.43953946232795715,
0.17511248588562012,
-0.31938475370407104,
0.7154546976089478,
-0.08829492330551147,
-0.5587477087974548,
-0.0884106233716011,
-0.11989792436361313,
0.2935710847377777,
-0.5861215591430664,
0.0059093995951116085,
0.12449426203966141,
0.3485243022441864,
-0.13047067821025848,
0.13239462673664093,
-0.2866460382938385,
0.6107794046401978,
0.14539295434951782,
0.3538239002227783,
-0.8870841264724731,
0.34142664074897766,
0.07921548187732697,
0.01251725573092699,
-0.353094220161438,
-0.03425966575741768,
0.04578350484371185,
0.3791620433330536,
0.4270089268684387,
0.1366206705570221,
-0.3052350580692291,
0.2489284873008728,
-0.17374812066555023,
0.5239741802215576,
-0.2548678517341614,
0.022241057828068733,
0.21115484833717346,
0.09039156883955002,
0.21331249177455902,
-0.45537593960762024,
0.06016828492283821,
0.06689035147428513,
0.06489306688308716,
-0.11840521544218063,
-0.5648060441017151,
0.11772841960191727,
0.3223990201950073,
-0.035199977457523346,
-0.24866405129432678,
0.045855987817049026,
0.04581938311457634,
-0.4395422339439392,
-0.02497108466923237,
-0.25126805901527405,
0.10128432512283325,
-0.6434839963912964,
0.14426738023757935,
0.2776007056236267,
0.3874409794807434,
0.29306524991989136,
0.9544300436973572,
-0.5777637958526611,
-0.31525033712387085,
-0.05252637714147568,
0.4946522116661072,
0.6454744338989258,
-0.036581847816705704,
0.11336510628461838,
0.11205288022756577,
0.37308549880981445,
-0.5698131322860718,
-0.06844966858625412,
-0.08498404175043106,
0.5208557844161987,
-0.04359983652830124,
0.5048003792762756,
0.7294377684593201,
-0.15348802506923676,
-0.21869556605815887,
-0.8336755633354187,
0.2915469706058502,
0.31406861543655396,
0.19188766181468964,
0.3702169954776764,
0.5744662284851074,
0.9999587535858154,
-0.028840715065598488,
-0.38376379013061523,
0.5101132988929749,
0.06732972711324692,
0.09009106457233429,
0.2814605236053467,
0.7766808867454529,
0.36234745383262634,
0.7237169742584229,
-0.3201836347579956,
0.24679718911647797,
0.26327410340309143,
-0.05930685997009277,
-0.07478033006191254,
-0.6128531694412231,
-0.42422619462013245,
-0.0102622639387846,
1.2129968404769897,
0.17999812960624695,
0.030256392434239388,
0.1938333660364151,
0.4515882432460785,
0.3894660770893097,
-0.2456669956445694,
0.11376792192459106,
0.2516370117664337,
-0.7681406140327454,
0.4069012999534607,
-0.5390715599060059,
-0.16590516269207,
-0.07375231385231018,
-0.3502088487148285,
0.277324378490448,
0.20667225122451782,
-0.8738945126533508,
-0.1144954115152359,
0.004924905952066183,
-0.2881582975387573,
-0.3771665394306183,
0.02094670571386814,
-0.09195335954427719,
0.265328586101532,
-0.17270003259181976,
0.5424834489822388,
-0.0422368198633194,
-0.03198423981666565,
-0.12195936590433121,
-0.2216026335954666,
-0.0981605127453804,
-0.5657776594161987,
0.14897318184375763,
0.6853451132774353,
-0.44906675815582275,
-0.1701459437608719,
0.2499352991580963,
-0.22354543209075928,
0.3496633768081665,
-0.6218976974487305,
0.2292231023311615,
0.21741434931755066,
-0.3194352388381958,
-0.030973227694630623,
-0.11402411758899689,
-0.06355036795139313,
-0.27140486240386963,
0.38767209649086,
-0.1279066950082779,
0.56609708070755,
-0.28670185804367065,
0.08106035739183426,
-0.2607753276824951,
-0.2502409815788269,
-0.6413813233375549,
-0.02325775846838951,
0.24231375753879547,
0.6362529397010803,
0.3107115626335144,
0.013563660904765129,
-0.07129412144422531,
-0.24733281135559082,
0.09783031046390533,
-0.43126705288887024,
0.34500542283058167,
-0.3232496380805969,
-0.20319567620754242,
-0.03722372278571129,
0.34158921241760254,
0.3871460258960724,
0.2355644255876541,
-0.29158321022987366,
0.29937270283699036,
-0.23990367352962494,
-0.31352269649505615,
0.7402492165565491,
-0.4175809323787689,
-0.5035938024520874,
-0.8605797290802002,
-0.8731892704963684,
-0.40696442127227783,
0.6495620608329773,
-0.4679439067840576,
-0.5150646567344666,
0.024472232908010483,
-0.05333111807703972,
0.23479589819908142,
-0.15308237075805664,
0.341418981552124,
-0.913975179195404,
-0.00574164604768157,
-0.7560790181159973,
0.37194618582725525,
-0.6943647265434265,
0.18071237206459045,
0.5126290917396545,
-0.5228005647659302,
-0.06612910330295563,
0.4505038857460022,
-0.1682194471359253,
-0.5756604671478271,
0.05356123298406601,
0.25449517369270325,
0.20912086963653564,
0.2967536449432373,
0.01805892214179039,
-0.3801927864551544,
-0.4754263162612915,
0.008263390511274338,
-0.6357805132865906,
0.003354697022587061,
-0.09872987866401672,
-0.21425944566726685,
0.04882713034749031,
-0.3698408603668213,
-0.30110758543014526,
-0.6202330589294434,
-0.2455524206161499,
0.014960197731852531
] |
Hematopoietic stem cells (HSCs) sustain blood formation throughout life and are the functional units of bone marrow transplantation. We show that transient expression of six transcription factors Run1t1, Hlf, Lmo2, Prdm5, Pbx1, and Zfp37 imparts multilineage transplantation potential onto otherwise committed lymphoid and myeloid progenitors and myeloid effector cells. Inclusion of Mycn and Meis1 and use of polycistronic viruses increase reprogramming efficacy. The reprogrammed cells, designated induced-HSCs (iHSCs), possess clonal multilineage differentiation potential, reconstitute stem/progenitor compartments, and are serially transplantable. Single-cell analysis revealed that iHSCs derived under optimal conditions exhibit a gene expression profile that is highly similar to endogenous HSCs. These findings demonstrate that expression of a set of defined factors is sufficient to activate the gene networks governing HSC functional identity in committed blood cells. Our results raise the prospect that blood cell reprogramming may be a strategy for derivation of transplantable stem cells for clinical application. | [
-0.00463508116081357,
0.0006047955248504877,
0.00032953533809632063,
0.01252327673137188,
0.015071211382746696,
-0.021831706166267395,
0.008285106159746647,
-0.01842600107192993,
-0.01061216276139021,
-0.03734634816646576,
-0.0029416184406727552,
0.008181317709386349,
0.003896219888702035,
0.010602216236293316,
0.001042461022734642,
0.005138185806572437,
-0.011058451607823372,
-0.020663823932409286,
0.012449914589524269,
-0.01886160671710968,
-0.006097498349845409,
0.013779626227915287,
0.00913369469344616,
-0.03238529711961746,
-0.0136228883638978,
0.009872275404632092,
0.014649888500571251,
-0.001594050321727991,
-0.012735261581838131,
0.0033573214896023273,
0.011349206790328026,
0.005749640055000782,
-0.005497748963534832,
-0.003898987080901861,
0.017426948994398117,
0.0060192677192389965,
0.004106157459318638,
0.0213966965675354,
0.017419785261154175,
-0.004320825915783644,
0.016409847885370255,
-0.008288953453302383,
0.0012540197931230068,
-0.01023981161415577,
-0.01070295087993145,
-0.004419827833771706,
-0.0018390368204563856,
0.004851622972637415,
0.005576744209975004,
0.006188635714352131,
-0.014229441992938519,
-0.007803185377269983,
-0.008894074708223343,
0.004076711367815733,
-0.005126578733325005,
-0.014344016090035439,
0.016826307401061058,
0.009508056566119194,
0.0241256020963192,
0.02850232645869255,
-0.010746180079877377,
0.00023268302902579308,
0.015406880527734756,
0.027620535343885422,
-0.01513313315808773,
-0.0668865367770195,
-0.004119185730814934,
0.02962925098836422,
-0.008814917877316475,
0.00003605056554079056,
0.0034864237532019615,
0.007142466027289629,
0.023427939042448997,
-0.014324325136840343,
-0.000772521598264575,
-0.014162953943014145,
-0.02497730404138565,
-0.0016877073794603348,
0.002696182345971465,
0.01982259750366211,
0.051666051149368286,
-0.00600959500297904,
0.015275716781616211,
-0.0015087805222719908,
0.011794949881732464,
0.017895665019750595,
-0.024904396384954453,
-0.013707928359508514,
0.01866096816956997,
-0.04920566827058792,
-0.0009392568608745933,
0.030774787068367004,
-0.019683830440044403,
0.0023362860083580017,
-0.005785245448350906,
-0.031808674335479736,
-0.008348249830305576,
-0.030016254633665085,
-0.00933635514229536,
0.0109372828155756,
-0.01871579699218273,
0.007329485844820738,
0.009357619099318981,
0.010041467845439911,
-0.005113973282277584,
0.007480922620743513,
-0.010522234253585339,
0.01973670721054077,
0.002021913882344961,
0.007786818780004978,
-0.016146574169397354,
0.0027712639421224594,
-0.014571260660886765,
0.01803581230342388,
0.015790384262800217,
-0.022469572722911835,
-0.012337159365415573,
-0.0008576251566410065,
0.012543151155114174,
-0.00351601536385715,
-0.0055487677454948425,
-0.006005256902426481,
-0.005120160058140755,
-0.010717449709773064,
0.008500808849930763,
-0.006235781125724316,
-0.034446876496076584,
-0.01616516336798668,
-0.023760827258229256,
-0.012700466439127922,
-0.00782499834895134,
0.004948730580508709,
0.025661271065473557,
-0.03926076367497444,
-0.024646412581205368,
-0.007304786704480648,
-0.016505330801010132,
0.014706384390592575,
0.002197613939642906,
0.0016368393553420901,
-0.013727547600865364,
0.004237242043018341,
0.001260306453332305,
0.011105670593678951,
-0.00832231342792511,
-0.013484282419085503,
-0.004014262929558754,
0.0005271676345728338,
-0.021233145147562027,
-0.026796698570251465,
0.012792619876563549,
-0.011785370297729969,
-0.018496982753276825,
-0.017703214660286903,
0.002422409364953637,
0.03847918659448624,
-0.023850858211517334,
-0.030997848138213158,
0.0018791728653013706,
0.016430692747235298,
-0.025421179831027985,
-0.003306771395727992,
0.026067223399877548,
0.01030208170413971,
0.01786014251410961,
0.003722202032804489,
-0.001189577393233776,
-0.008852332830429077,
0.011191792786121368,
0.007677407003939152,
-0.008731822483241558,
0.010325398296117783,
0.00365773169323802,
0.006308587267994881,
-0.011484785936772823,
-0.004430095665156841,
0.018574610352516174,
0.008366161957383156,
-0.015009886585175991,
0.0664934515953064,
0.0250314362347126,
0.011959097348153591,
-0.01739271730184555,
0.0115872323513031,
0.005488117225468159,
-0.002525783609598875,
0.007121327333152294,
-0.010372301563620567,
-0.003158515552058816,
-0.011086661368608475,
0.02565457858145237,
-0.031154995784163475,
-0.00300604198127985,
0.015721015632152557,
-0.009713471867144108,
0.001577191287651658,
0.015942104160785675,
0.007178963162004948,
-0.020953936502337456,
0.00858918484300375,
0.041726723313331604,
-0.023835748434066772,
0.021900974214076996,
-0.018521731719374657,
-0.013916079886257648,
0.01281486451625824,
0.010720915161073208,
-0.028711453080177307,
0.002961965976282954,
0.023326555266976357,
0.005970340222120285,
0.0006224121898412704,
0.003289290936663747,
-0.011895000003278255,
0.000930758542381227,
0.01186980027705431,
0.00292030768468976,
0.0366208478808403,
-0.012003794312477112,
-0.010257194750010967,
0.005071899387985468,
-0.007847504690289497,
0.01810094341635704,
-0.020439177751541138,
-0.009278968907892704,
-0.02126120589673519,
0.007270090281963348,
0.010145112872123718,
-0.008178932592272758,
0.022027237340807915,
-0.009499812498688698,
-0.03700559586286545,
-0.012232877314090729,
0.003964845556765795,
-0.0035501401871442795,
0.005237596109509468,
0.012350999750196934,
-0.014842206612229347,
0.021587733179330826,
-0.010485043749213219,
-0.010890564881265163,
0.0017306609079241753,
0.030577994883060455,
-0.02722173184156418,
0.005074094515293837,
-0.01759866625070572,
-0.0004442548379302025,
0.010119890794157982,
0.005656479392200708,
-0.015713540837168694,
0.0060462248511612415,
0.023898199200630188,
0.0021896744146943092,
0.009505500085651875,
-0.0021628106478601694,
-0.005975472740828991,
-0.0028479737229645252,
0.0337287038564682,
0.023189209401607513,
-0.007628160063177347,
-0.01058608666062355,
0.0020929649472236633,
-0.004479799885302782,
-0.00017363997176289558,
-0.026376482099294662,
-0.029284179210662842,
0.022064391523599625,
0.01822015829384327,
0.014863425865769386,
-0.009961090050637722,
0.013214822858572006,
-0.0024801825638860464,
0.01192842610180378,
-0.08109336346387863,
-0.011496143415570259,
0.010349282063543797,
0.00705856503918767,
0.008073583245277405,
-0.006394454278051853,
0.0020118909887969494,
0.018116291612386703,
-0.009345904923975468,
0.006626112386584282,
-0.004984389990568161,
0.007834691554307938,
-0.01252531073987484,
0.008130909875035286,
-0.02891596034169197,
-0.0020400104112923145,
0.011401373893022537,
0.003409452736377716,
0.0022874544374644756,
0.008772831410169601,
0.0010314513929188251,
-0.02464197389781475,
-0.04013926535844803,
0.016846109181642532,
-0.02055325172841549,
0.013543887063860893,
0.008634578436613083,
-0.0036525302566587925,
-0.02431291900575161,
-0.0008974327938631177,
-0.019356999546289444,
-0.0021294450853019953,
-0.0004207226447761059,
-0.00860784575343132,
0.009631715714931488,
-0.0005456320941448212,
0.011554485186934471,
0.009975132532417774,
-0.0050638350658118725,
0.029079675674438477,
-0.022908523678779602,
0.012173641473054886,
0.015386352315545082,
0.006441997364163399,
-0.0009290507296100259,
0.000613827898632735,
0.012706073932349682,
0.0050327368080616,
0.013280127197504044,
0.007018428761512041,
-0.008930280804634094,
-0.0052763354033231735,
0.014043854549527168,
0.015082046389579773,
-0.017704764381051064,
-0.008218158036470413,
-0.013195278123021126,
-0.0029460303485393524,
-0.01336607150733471,
-0.015257604420185089,
0.017389344051480293,
-0.007723389193415642,
0.008398398756980896,
-0.005193512886762619,
-0.00422627804800868,
0.01915033906698227,
0.009121276438236237,
-0.0020019952207803726,
-0.0367027148604393,
-0.002997839590534568,
0.01418646052479744,
-0.02372445911169052,
0.0030317138880491257,
-0.01093091256916523,
-0.013553420081734657,
-0.014623415656387806,
-0.0140038738027215,
0.0027392853517085314,
0.028799232095479965,
-0.01153783593326807,
-0.043337322771549225,
-0.019094817340373993,
-0.03291996940970421,
0.0032176196109503508,
-0.01660780981183052,
-0.02929261326789856,
0.010785656049847603,
0.012087343260645866,
0.012190363369882107,
-0.00831835437566042,
-0.003926094621419907,
0.0006506682839244604,
0.005521209444850683,
0.007791445590555668,
0.011324800550937653,
-0.025759248062968254,
0.0022662742994725704,
0.001447909977287054,
0.013879494741559029,
0.00563374487683177,
-0.02721630223095417,
0.0008319411426782608,
0.00046612881124019623,
-0.01203482411801815,
-0.0014669587835669518,
0.012819048017263412,
-0.008990529924631119,
-0.015627767890691757,
0.0020533096976578236,
-0.0008536552777513862,
0.0008726939558982849,
-0.002109553199261427,
-0.007570993155241013,
0.008846218697726727,
0.011230370961129665,
0.023667478933930397,
-0.0030027483589947224,
-0.03142847120761871,
0.07258282601833344,
0.006903580389916897,
-0.010840289294719696,
-0.021273568272590637,
-0.012772312387824059,
-0.03471902012825012,
-0.0058555505238473415,
0.01412340346723795,
-0.02676146849989891,
-0.012481764890253544,
0.010716191492974758,
0.008922824636101723,
0.0017370163695886731,
0.011797207407653332,
-0.017679918557405472,
-0.014645406976342201,
-0.03863755613565445,
-0.02540324628353119,
-0.006348764523863792,
0.007047554478049278,
-0.005335370544344187,
0.01484149694442749,
-0.0037918416783213615,
-0.0036134442780166864,
0.020323721691966057,
-0.027270730584859848,
-0.03516377508640289,
-0.008415549993515015,
0.01229416485875845,
0.01568993367254734,
0.02917732112109661,
0.00017034728080034256,
-0.004783069249242544,
-0.00823152530938387,
0.03624420613050461,
0.012458067387342453,
0.008736932650208473,
0.017005618661642075,
-0.011834927834570408,
0.005648909602314234,
-0.018284374848008156,
-0.009115335531532764,
0.011148130521178246,
0.013848332688212395,
0.010194406844675541,
-0.0005746048409491777,
0.026730138808488846,
-0.005744715221226215,
0.005275650881230831,
-0.007360098417848349,
-0.007441191002726555,
0.011902494356036186,
0.019407831132411957,
-0.02210363745689392,
0.006361857987940311,
-0.002873710822314024,
0.01316087320446968,
0.00013462454080581665,
-0.006715156137943268,
-0.011480088345706463,
-0.018525980412960052,
-0.014255428686738014,
-0.010028739459812641,
-0.031443290412425995,
0.022284340113401413,
-0.01645233854651451,
-0.010310620069503784,
0.008429735898971558,
0.008625192567706108,
-0.0039374795742332935,
0.010795995593070984,
0.008159453980624676,
-0.014175551012158394,
-0.006285504437983036,
0.006267953664064407,
-0.012683972716331482,
0.006339475512504578,
-0.004598677158355713,
0.02510666474699974,
0.0021782247349619865,
-0.012375397607684135,
0.004068133421242237,
-0.010148975066840649,
-0.01723404973745346,
0.0037296246737241745,
0.0014681881293654442,
-0.01297728531062603,
-0.07492925226688385,
-0.016878589987754822,
-0.007940598763525486,
-0.006566241383552551,
0.008413483388721943,
0.003898374270647764,
-0.02470167726278305,
0.020263664424419403,
0.006401686929166317,
-0.00483773835003376,
0.0247776098549366,
-0.02281416580080986,
-0.012220758944749832,
0.016955409198999405,
0.009780513122677803,
0.004551524296402931,
-0.005439384840428829,
0.013381917029619217,
-0.009762516245245934,
-0.006404024548828602,
-0.009025591425597668,
0.013706604018807411,
-0.038981612771749496,
-0.003301441203802824,
0.0026857806369662285,
-0.08139815181493759,
0.018523063510656357,
-0.006764374207705259,
-0.02340289205312729,
-0.005102289840579033,
-0.02595074474811554,
0.005237368401139975,
0.0026375369634479284,
-0.009023471735417843,
-0.011612499132752419,
0.000877829035744071,
-0.004031630232930183,
0.013312027789652348,
-0.014126777648925781,
0.013235530816018581,
-0.0063382601365447044,
0.02262362651526928,
-0.012623405084013939,
-0.011533909477293491,
0.02480405569076538,
-0.004735846072435379,
0.0008478949312120676,
-0.008249863982200623,
-0.005798066034913063,
-0.012527219951152802,
-0.029333122074604034,
-0.0021382300183176994,
0.007380294613540173,
0.013347364962100983,
0.0025787819176912308,
-0.021717004477977753,
-0.007261501159518957,
-0.000323588028550148,
0.016646431758999825,
-0.014171077869832516,
-0.029108572751283646,
-0.012522520497441292,
-0.007747927214950323,
-0.039882905781269073,
0.005730666685849428,
-0.0030009131878614426,
0.007983456365764141,
0.0034784513991326094,
-0.006534115877002478,
0.021224090829491615,
-0.004294893238693476,
0.005602115765213966,
-0.006340696010738611,
0.015339961275458336,
0.022260986268520355,
0.0037625478580594063,
0.015506595373153687,
-0.014626753516495228,
-0.01477530412375927,
-0.03006322681903839,
-0.010031177662312984,
0.0030574784614145756,
0.007315841503441334,
0.02163412794470787,
0.009509801864624023,
0.0022757072001695633,
0.0006560781039297581,
0.010172209702432156,
0.07150834798812866,
-0.026274792850017548,
-0.009311494417488575,
-0.00724803889170289,
-0.006261501461267471,
0.006135980598628521,
-0.024041756987571716,
-0.027569131925702095,
-0.0334639698266983,
0.011919626966118813,
-0.01380831841379404,
-0.005573618225753307,
0.007904358208179474,
0.014659592881798744,
0.014924975112080574,
-0.01465772744268179,
0.011832783930003643,
0.013962728902697563,
-0.020901601761579514,
0.013488119468092918,
-0.0003786161541938782,
-0.02821088582277298,
-0.0034471387043595314,
-0.004303068853914738,
0.008769074454903603,
-0.004967029206454754,
-0.030042801052331924,
-0.0032820519991219044,
-0.00006211875006556511,
0.0031773094087839127,
-0.0024190708063542843,
-0.021266521885991096,
0.004207868129014969,
-0.008870395831763744,
0.026711124926805496,
0.03071533516049385,
-0.010661505162715912,
0.004706497769802809,
-0.004553589969873428,
-0.01582244411110878,
0.015981214120984077,
0.005568795837461948,
-0.007273875176906586,
-0.009739059954881668,
0.020892467349767685,
-0.014394139871001244,
0.004041452892124653,
-0.005380911752581596,
-0.045481786131858826,
0.007488471921533346,
0.03710034862160683,
0.004296101629734039,
0.00919983722269535,
-0.013509717769920826,
-0.006693779490888119,
0.011768115684390068,
0.017290625721216202,
0.02458025887608528,
-0.01473977416753769,
0.0010654530487954617,
0.0010618949308991432,
-0.009757446125149727,
-0.019315602257847786,
-0.016550704836845398,
0.024485792964696884,
-0.006947947666049004,
0.01649046689271927,
-0.007104558404535055,
-0.015073617920279503,
0.011746401898562908,
0.007588312961161137,
0.02224719524383545,
0.008050048723816872,
-0.009737319312989712,
0.004321451298892498,
-0.00729965977370739,
0.022013824433088303,
-0.012379121035337448,
0.0217268206179142,
0.01619570702314377,
-0.004246232099831104,
0.013537447899580002,
0.017093125730752945,
0.02966690994799137,
-0.012687081471085548,
-0.014060336165130138,
-0.006154299713671207,
0.012060122564435005,
0.0032305934000760317,
0.008535297587513924,
0.0311544518917799,
-0.0005058459937572479,
-0.0025129104033112526,
0.020350314676761627,
0.004805718082934618,
0.032937612384557724,
0.0029670875519514084,
0.009308491833508015,
-0.007512962445616722,
0.03554660826921463,
0.006349671632051468,
0.007750893943011761,
-0.0016500846249982715,
-0.023209985345602036,
0.004040521569550037,
-0.005268117878586054,
-0.001360954251140356,
0.00809538271278143,
0.009967822581529617,
-0.003003731369972229,
0.00993760209530592,
-0.01114169042557478,
0.006132382899522781,
-0.0007712938822805882,
-0.012996233999729156,
0.033004820346832275,
-0.01862897351384163,
0.013371841982007027,
-0.0028255037032067776,
-0.01764906570315361,
-0.02321344055235386,
-0.0038207019679248333,
-0.001216802978888154,
0.007010961417108774,
-0.005694187246263027,
-0.022955939173698425,
-0.011083690449595451,
0.013671495951712132,
-0.013239629566669464,
0.033156029880046844,
0.011027303524315357,
-0.010111989453434944,
-0.017368393018841743,
0.013715587556362152,
0.002737663686275482,
-0.019871901720762253,
-0.0034013139083981514,
0.003111656289547682,
0.0002874645870178938,
0.029287129640579224,
0.01933354139328003,
-0.001815909636206925,
-0.0015339052770286798,
-0.0031923484057188034,
0.006734141148626804,
0.00480789877474308,
0.0021131448447704315,
0.0021800275426357985,
0.014210786670446396,
0.0033062868751585484,
0.0003188233822584152,
0.0025767977349460125,
0.017913496121764183,
-0.009860808961093426,
0.019969265908002853,
0.012015526182949543,
0.006374867632985115,
-0.012938086874783039,
-0.01066839974373579,
0.00501493364572525,
0.0019809610676020384,
-0.0030152699910104275,
-0.015625469386577606,
-0.0012572003761306405,
0.015024073421955109,
-0.0037940165493637323,
0.011607147753238678,
-0.012640890665352345,
0.007408777251839638,
0.004936513490974903,
-0.00021942565217614174,
0.018884824588894844,
-0.016789104789495468,
0.0007759621366858482,
-0.019400732591748238,
-0.007278865203261375,
-0.018152842298150063,
-0.019111178815364838,
0.008193952962756157,
-0.017482101917266846,
0.019164156168699265,
-0.012100747786462307,
-0.0005808891728520393,
-0.003529139794409275,
0.0037618631031364202,
-0.0014627068303525448,
-0.004240361973643303,
-0.0025299566332250834,
-0.0038030350115150213,
-0.001492857001721859,
-0.030563388019800186,
0.0030555548146367073,
0.001822102814912796,
0.01564236544072628,
-0.014287617057561874,
0.031160663813352585,
0.023451518267393112,
-0.009613950736820698,
0.0115119107067585,
-0.0023548086173832417,
0.036489181220531464,
-0.021786939352750778
] | [
0.13635055720806122,
-0.12133517861366272,
0.493112176656723,
0.3573910593986511,
0.4207477271556854,
0.2062017321586609,
0.09368443489074707,
0.07200300693511963,
0.08209870010614395,
-0.6888957023620605,
-0.11317263543605804,
0.13691359758377075,
-0.21460223197937012,
0.03853829577565193,
0.13375161588191986,
0.08225986361503601,
0.40634626150131226,
0.5420441031455994,
-0.13786283135414124,
-0.7460846304893494,
-0.4545326232910156,
-0.39901649951934814,
0.3998927175998688,
0.2610398232936859,
0.2989330589771271,
-0.07852227240800858,
-0.07636673748493195,
-0.3852445185184479,
0.4834749400615692,
-0.034108635038137436,
0.38432776927948,
0.4552355408668518,
0.013608586974442005,
-0.4426417350769043,
-0.1575363278388977,
0.01256145816296339,
-0.3687489628791809,
-0.21276770532131195,
0.09980146586894989,
-0.35390380024909973,
-0.3754116892814636,
-0.21998701989650726,
-0.12128535658121109,
0.5741473436355591,
-0.11544428020715714,
-0.1563577502965927,
-1.0702178478240967,
0.8622050881385803,
-0.35429149866104126,
0.2667255401611328,
0.09387354552745819,
-0.09042631834745407,
-0.3091268539428711,
0.19157402217388153,
0.24700772762298584,
-0.0805397629737854,
-0.6189214587211609,
-0.08847586065530777,
0.32068824768066406,
-0.58833909034729,
0.025929352268576622,
-0.17998754978179932,
-0.32815873622894287,
0.15889713168144226,
-0.3183421492576599,
0.18386200070381165,
0.319986492395401,
-0.5787393450737,
-0.5055475234985352,
-0.6782687306404114,
0.4571627974510193,
-0.3175064027309418,
-0.0019219762180000544,
0.43533238768577576,
0.10318095237016678,
-0.30789315700531006,
-0.3606767952442169,
-0.15503574907779694,
0.4170841574668884,
0.14391054213047028,
-0.051006242632865906,
0.07948015630245209,
0.026398075744509697,
0.354979008436203,
0.426318883895874,
0.18884128332138062,
-0.03211849927902222,
0.4367523491382599,
-0.44326233863830566,
0.10056165605783463,
-0.0380559042096138,
0.05321209132671356,
0.35211411118507385,
-0.03514263778924942,
0.3855151832103729,
0.4629177749156952,
0.30205658078193665,
-0.4134960472583771,
0.15384526550769806,
-0.11386722326278687,
-0.5163765549659729,
0.29670727252960205,
-0.29026228189468384,
-0.7244920134544373,
-0.4154597520828247,
-0.06722219288349152,
0.025710618123412132,
-0.2956255078315735,
-0.4860861897468567,
-0.25826334953308105,
-0.28747859597206116,
-0.3587351143360138,
-0.0781506597995758,
-0.07051673531532288,
0.011984458193182945,
0.07123897969722748,
0.3340575098991394,
-0.21781468391418457,
0.06254586577415466,
0.11658791452646255,
-0.0279496181756258,
0.9900386333465576,
-0.13163505494594574,
0.2924669682979584,
-0.09061268717050552,
0.033613983541727066,
0.6626359820365906,
0.14924027025699615,
-0.3608458936214447,
0.42824819684028625,
-0.05517607554793358,
0.6339714527130127,
-0.3119407296180725,
0.10219711065292358,
0.16687732934951782,
-0.18213745951652527,
0.42552390694618225,
0.052737414836883545,
0.48783332109451294,
0.25606614351272583,
-0.7892704606056213,
-0.7439598441123962,
-0.010398457758128643,
-0.19208258390426636,
0.11305360496044159,
-0.5005717873573303,
-0.17510926723480225,
-0.0376683846116066,
0.17671829462051392,
-0.3527419865131378,
-0.12130311131477356,
-0.04807131364941597,
-0.4371770918369293,
-0.14763379096984863,
0.05466238781809807,
0.8318570852279663,
0.3685583174228668,
-0.06977513432502747,
-0.05237607657909393,
0.4316834509372711,
0.29463228583335876,
0.3408101499080658,
0.05088821053504944,
-0.2908225655555725,
0.19340427219867706,
0.328170508146286,
0.31883320212364197,
0.5447134971618652,
-0.2655240595340729,
-0.008391899056732655,
-0.24539145827293396,
-0.4582190215587616,
0.3206546902656555,
-0.7745004892349243,
0.05126291885972023,
0.1416303962469101,
0.6561990976333618,
-0.10048030316829681,
-0.029029695317149162,
-0.004120432306081057,
-0.6890673041343689,
0.6462689638137817,
-0.04004562273621559,
-0.39031100273132324,
0.094334177672863,
-0.18852323293685913,
0.303579717874527,
0.051959551870822906,
-0.022474275901913643,
0.2523380219936371,
0.045986466109752655,
-0.3958117365837097,
0.6947217583656311,
-0.3832339942455292,
1.365080714225769,
-0.23563989996910095,
-0.00019901695486623794,
0.9234619736671448,
-0.16782733798027039,
-0.14969798922538757,
-0.22379598021507263,
0.29478123784065247,
0.8245612978935242,
-0.4940677583217621,
-0.6460817456245422,
0.22241516411304474,
0.19569268822669983,
-0.4362826943397522,
0.025253942236304283,
-0.4471032917499542,
0.4998212158679962,
-0.3316621780395508,
-0.0327758751809597,
-0.07433585822582245,
0.27602142095565796,
-0.4250631332397461,
-0.5324587225914001,
-0.3432859182357788,
-0.2606017589569092,
-0.3571033775806427,
0.45784300565719604,
-0.36194494366645813,
0.6503130197525024,
0.6792929172515869,
-0.22470304369926453,
0.682526707649231,
-0.04354944825172424,
-0.028597569093108177,
0.7011274099349976,
0.05709989741444588,
0.34231510758399963,
-0.43335604667663574,
-0.11695761978626251,
-0.5280142426490784,
-0.21223531663417816,
0.02125924825668335,
0.20091545581817627,
-0.18447327613830566,
-0.10225515812635422,
0.13993225991725922,
-0.19419583678245544,
0.4592747688293457,
-0.5160436630249023,
-0.5425062775611877,
-0.2219271957874298,
-0.4240533709526062,
-0.25973448157310486,
-0.148147314786911,
-0.5019540190696716,
-0.0857696533203125,
-0.33933213353157043,
0.251913845539093,
-0.21428555250167847,
-0.40716552734375,
0.5463941097259521,
0.26894712448120117,
0.35488301515579224,
0.19818195700645447,
-0.44780340790748596,
-0.47377368807792664,
-0.10771642625331879,
0.1198333203792572,
0.03258989378809929,
0.388673335313797,
0.1748218983411789,
-0.8478715419769287,
-0.7203198075294495,
-0.34155821800231934,
1.1200512647628784,
0.4103354513645172,
0.4603355824947357,
0.00334595306776464,
-0.37170740962028503,
-0.19130030274391174,
-0.2901889681816101,
-0.4350772202014923,
0.13767504692077637,
0.5507874488830566,
-0.34731432795524597,
-0.10048871487379074,
-0.10130489617586136,
0.1482536792755127,
0.506780207157135,
-0.1394263505935669,
-0.24493268132209778,
0.43595483899116516,
-0.1403854936361313,
-0.07651987671852112,
-0.07092571258544922,
-0.140899196267128,
0.029002180323004723,
0.4209420084953308,
0.15076565742492676,
-0.0967109426856041,
0.38279277086257935,
-0.21163545548915863,
0.299472451210022,
0.4059210419654846,
0.30492380261421204,
0.2750661373138428,
-0.40528392791748047,
0.2555970549583435,
-0.20708808302879333,
0.11328475922346115,
-0.11256304383277893,
0.14578282833099365,
-0.6200609803199768,
0.3235095739364624,
-6.081474304199219,
-0.07369394600391388,
-0.1582871377468109,
-0.14969688653945923,
0.4227760434150696,
-0.14505943655967712,
0.6019836664199829,
0.1617574840784073,
0.22339268028736115,
-0.16117273271083832,
0.3085192143917084,
0.36743634939193726,
-0.19146187603473663,
-0.11028549075126648,
-0.27240532636642456,
-0.29059746861457825,
-0.6888589859008789,
-0.5108630657196045,
0.8270119428634644,
-0.22502350807189941,
-0.27974626421928406,
-0.703997015953064,
0.07348086684942245,
0.9143292903900146,
-0.42455577850341797,
-0.05774223804473877,
-1.0141228437423706,
-0.014777502045035362,
-0.3310120701789856,
-0.2793157994747162,
-0.11269068717956543,
-0.6121429800987244,
0.20436084270477295,
-0.024189261719584465,
-0.05598856136202812,
-0.09485844522714615,
0.13391737639904022,
0.13574638962745667,
-0.17917411029338837,
-0.5502647161483765,
0.3497026860713959,
-0.017602216452360153,
-0.46501678228378296,
-0.13394653797149658,
0.01463891752064228,
-0.28825604915618896,
0.151615172624588,
0.6636958122253418,
-0.2592650353908539,
0.8499650955200195,
0.1081562414765358,
0.05627279728651047,
0.2824220061302185,
0.3916648030281067,
0.5904235243797302,
0.02851281873881817,
-0.10414257645606995,
0.2998199462890625,
-0.22361700236797333,
0.0812680646777153,
-0.28271231055259705,
0.01136759389191866,
-0.08097511529922485,
-0.42824360728263855,
0.19692178070545197,
0.2609364986419678,
-0.9340972304344177,
-0.33210861682891846,
0.19933666288852692,
-0.02249450981616974,
0.14976529777050018,
0.7171481251716614,
0.0733562633395195,
-0.549573540687561,
0.2800680994987488,
-0.5798238515853882,
0.5701300501823425,
-0.08688486367464066,
0.12910188734531403,
0.2909601628780365,
-0.05077284574508667,
-0.06321347504854202,
0.2428036630153656,
-0.4584857225418091,
0.19563691318035126,
-0.27622392773628235,
-0.2881753742694855,
0.005971934180706739,
0.18578298389911652,
0.17604435980319977,
0.3060535490512848,
-0.14255563914775848,
0.1097436174750328,
0.4704200029373169,
0.2555325925350189,
0.44447454810142517,
0.19294950366020203,
0.6372692584991455,
0.24006666243076324,
0.09198459982872009,
1.2403441667556763,
0.19230309128761292,
-0.42735323309898376,
-0.8255482316017151,
-0.4280935227870941,
0.24408738315105438,
-0.6852619051933289,
0.4499847888946533,
0.3900199830532074,
-0.6524074077606201,
0.1412893533706665,
-0.06609921902418137,
-0.09668585658073425,
-0.35569825768470764,
0.5360851883888245,
-0.03889738768339157,
-0.16348202526569366,
-0.06643525511026382,
0.8206088542938232,
0.01574268378317356,
0.4324644207954407,
0.18312934041023254,
-0.4250832498073578,
0.36798426508903503,
0.709843635559082,
0.13799816370010376,
0.2626197934150696,
1.0025298595428467,
-0.6099815964698792,
-0.32795029878616333,
0.26750612258911133,
0.1358398050069809,
-0.14823581278324127,
0.11005481332540512,
0.2840549051761627,
-0.2173425406217575,
-0.7096523642539978,
0.5796061754226685,
0.11558979749679565,
0.10779628902673721,
0.47945380210876465,
-0.28399044275283813,
-0.3340871036052704,
0.36395564675331116,
0.43963000178337097,
-0.12126173079013824,
-0.5947591662406921,
-0.01595989242196083,
0.043797191232442856,
-0.22148822247982025,
0.2544143795967102,
-0.1415863037109375,
0.2719458043575287,
-0.5786716938018799,
-0.08201172202825546,
0.07402388751506805,
0.4465091824531555,
0.040756650269031525,
0.16635988652706146,
-0.5917631387710571,
-0.07490787655115128,
0.30232489109039307,
-0.8700134754180908,
0.07422327995300293,
-0.6682606935501099,
-0.10534898191690445,
-0.10355546325445175,
-0.5470799207687378,
-0.6885250210762024,
0.12578150629997253,
-0.3737735450267792,
-0.12807025015354156,
-0.07487187534570694,
-0.05879225954413414,
0.3552398681640625,
-0.4096156060695648,
-0.2261190265417099,
0.020812150090932846,
0.20356257259845734,
0.0023538440000265837,
0.02659234032034874,
-0.3948315978050232,
-0.15827210247516632,
-0.061490606516599655,
0.7025773525238037,
0.026187410578131676,
0.056815408170223236,
-0.21308469772338867,
-0.20722556114196777,
0.11345772445201874,
0.04433539882302284,
0.35361114144325256,
-0.26288938522338867,
-0.18996001780033112,
0.06899843364953995,
0.17531204223632812,
-0.23670466244220734,
0.3785340189933777,
0.3298340439796448,
-0.2718072831630707,
0.5953401327133179,
0.17468704283237457,
-0.23858720064163208,
0.2655014395713806,
0.628692090511322,
-0.016572099179029465,
-0.34464454650878906,
0.313624769449234,
-0.06387243419885635,
-0.11931458115577698,
0.13514889776706696,
-0.5636340379714966,
0.33023402094841003,
0.3566676080226898,
-0.30198782682418823,
-0.35241007804870605,
0.005210127681493759,
-0.43453139066696167,
-0.28597575426101685,
0.5427054166793823,
0.24656078219413757,
0.1480056196451187,
0.245588019490242,
0.07536463439464569,
-0.5819755792617798,
0.11924202740192413,
0.23942004144191742,
-1.0745518207550049,
0.10355774313211441,
0.2842077910900116,
-0.20194435119628906,
-0.32291939854621887,
-0.22525931894779205,
-0.14038245379924774,
0.3182092308998108,
-0.33365002274513245,
-0.13429389894008636,
0.08505325764417648,
-0.595339834690094,
-0.051742084324359894,
0.11762577295303345,
0.5172180533409119,
-0.42680126428604126,
-0.4186840057373047,
0.007141725160181522,
0.7620008587837219,
0.24257053434848785,
-0.6953677535057068,
-0.20009469985961914,
0.13552145659923553,
0.4101620614528656,
-0.2787688970565796,
0.4003464877605438,
0.38268473744392395,
0.5644415020942688,
0.4103070795536041,
0.11387906223535538,
-0.2311474233865738,
0.0001676353276707232,
0.10470453649759293,
-0.3383840322494507,
-0.46042460203170776,
-0.15801380574703217,
0.018347423523664474,
0.2965289056301117,
-0.2122499644756317,
-0.11193089932203293,
-0.34513211250305176,
0.36891064047813416,
-0.12440080940723419,
0.22200752794742584,
-0.08688069134950638,
0.7595237493515015,
0.23130439221858978,
-0.4998400807380676,
0.3215825855731964,
-0.19448456168174744,
0.26259171962738037,
-0.08853468298912048,
0.2649974524974823,
-0.3418824076652527,
-0.6566976308822632,
0.16423305869102478,
0.16372255980968475,
0.29835888743400574,
-0.5470699667930603,
0.5129656791687012,
-0.4165290296077728,
0.3542849123477936,
0.06357122957706451,
-0.06918049603700638,
0.10513510555028915,
-0.3677506446838379,
0.005399469286203384,
0.33451271057128906,
0.20025356113910675,
0.3833006024360657,
0.34074848890304565,
0.017110124230384827,
0.04575439915060997,
-0.4818269908428192,
0.45986419916152954,
0.38311970233917236,
-0.6479550004005432,
-0.07944173365831375,
0.3706459701061249,
0.2726191580295563,
0.12905199825763702,
-0.659080445766449,
0.03844283148646355,
0.43702176213264465,
-0.33877092599868774,
0.10297279059886932,
0.164543017745018,
0.09301866590976715,
-0.06933363527059555,
-0.45751458406448364,
-0.1938505321741104,
0.11579930782318115,
0.2849169671535492,
0.1230488047003746,
1.1022001504898071,
0.139626607298851,
-0.2741047739982605,
-0.17328788340091705,
0.2771621644496918,
0.2919454574584961,
0.10445304960012436,
-0.12896667420864105,
0.5576456785202026,
0.7070450782775879,
0.2761830985546112,
-0.23436501622200012,
0.7274990677833557,
0.3515048325061798,
0.011318537406623363,
-0.06909064948558807,
-0.48689985275268555,
-0.23773424327373505,
0.01170292217284441,
0.46179449558258057,
0.11439035087823868,
-0.06865553557872772,
-0.11039458215236664,
-0.19152969121932983,
0.30658429861068726,
-0.005520496051758528,
0.41799110174179077,
-0.08791377395391464,
0.07896527647972107,
0.5259224772453308,
-0.6029796600341797,
-0.31832554936408997,
0.06764141470193863,
-0.20022137463092804,
0.2277233898639679,
0.29421213269233704,
-0.0905345007777214,
-0.2499435842037201,
-0.06851942092180252,
-0.4072378873825073,
0.20155315101146698,
-0.10741763561964035,
0.5637726187705994,
0.3122800886631012,
-0.14511263370513916,
0.5159454941749573,
0.02736818976700306,
0.22040900588035583,
-0.29115620255470276,
-0.08384525775909424,
0.19959749281406403,
-0.14516885578632355,
0.29201093316078186,
0.21844764053821564,
-0.723373293876648,
-0.23662148416042328,
0.08662116527557373,
-0.11630337685346603,
0.1926473081111908,
-0.6520336866378784,
-0.2052561640739441,
0.045176126062870026,
-0.7156225442886353,
-0.2641122043132782,
-0.09656015038490295,
-0.21166709065437317,
-0.330037385225296,
0.10514327883720398,
0.19434377551078796,
0.2412097454071045,
-0.7510111927986145,
0.42497286200523376,
-0.03206542134284973,
0.24346792697906494,
-0.055952806025743484,
-0.013710105791687965,
0.05181260034441948,
0.3572528660297394,
0.3775358498096466,
-0.0687258392572403,
0.6410437226295471,
0.0845075249671936,
0.041093017905950546,
-0.6796375513076782,
0.2739620506763458,
-0.11185220628976822,
-0.2394157201051712,
-0.39055904746055603,
-0.06455796957015991,
0.7825777530670166,
0.5548816323280334,
-0.5827266573905945,
0.30611133575439453,
0.2828335762023926,
0.3516857922077179,
0.41751301288604736,
-0.3337668180465698,
-0.07830235362052917,
-0.5973813533782959,
-0.25773271918296814,
-0.42037996649742126,
0.22491611540317535,
0.09171099960803986,
-0.15481631457805634,
0.19284306466579437,
0.3626358211040497,
0.29424041509628296,
-0.42341348528862,
0.8566765785217285,
-0.6416630744934082,
0.34970900416374207,
-0.5748695731163025,
0.22971294820308685,
-0.09839790314435959,
0.033277757465839386,
-0.5258448719978333,
-0.276716411113739,
-0.06986036151647568,
-0.439666748046875,
0.08709793537855148,
-0.1605740487575531,
-0.4803473949432373,
0.010721963830292225,
-0.09417352825403214,
-0.10514389723539352,
0.006504973862320185,
-0.6817288398742676,
-0.7236117720603943,
0.020137397572398186,
0.16311217844486237,
-0.8202979564666748,
0.05239676684141159,
-0.083210788667202,
-0.16318310797214508,
-0.11285750567913055,
0.01416501309722662,
0.02534499391913414,
-0.05810588598251343,
0.19421955943107605
] |
Common recommendations for cell line authentication, annotation and quality control fall short addressing genetic heterogeneity. Within the Human Toxome Project, we demonstrate that there can be marked cellular and phenotypic heterogeneity in a single batch of the human breast adenocarcinoma cell line MCF-7 obtained directly from a cell bank that are invisible with the usual cell authentication by short tandem repeat (STR) markers. STR profiling just fulfills the purpose of authentication testing, which is to detect significant cross-contamination and cell line misidentification. Heterogeneity needs to be examined using additional methods. This heterogeneity can have serious consequences for reproducibility of experiments as shown by morphology, estrogenic growth dose-response, whole genome gene expression and untargeted mass-spectroscopy metabolomics for MCF-7 cells. Using Comparative Genomic Hybridization (CGH), differences were traced back to genetic heterogeneity already in the cells from the original frozen vials from the same ATCC lot, however, STR markers did not differ from ATCC reference for any sample. These findings underscore the need for additional quality assurance in Good Cell Culture Practice and cell characterization, especially using other methods such as CGH to reveal possible genomic heterogeneity and genetic drifts within cell lines. | [
0.008366409689188004,
0.0102990148589015,
-0.017907001078128815,
0.016372086480259895,
0.0005657651927322149,
0.010035267099738121,
0.012582064606249332,
0.0012345174327492714,
-0.01261363085359335,
-0.02700398489832878,
-0.0014645520132035017,
0.009927414357662201,
-0.01127564162015915,
0.022357501089572906,
-0.00425912719219923,
0.01598762720823288,
-0.022868294268846512,
-0.004694881848990917,
0.006199802737683058,
0.01795368269085884,
0.010476883500814438,
-0.012898266315460205,
0.010913794860243797,
-0.010424919426441193,
0.006889202166348696,
-0.033995553851127625,
0.004490331746637821,
-0.0023169340565800667,
-0.026394600048661232,
-0.05825614184141159,
0.00003308570012450218,
-0.0065439543686807156,
0.010113310068845749,
0.0031828703358769417,
0.006691566668450832,
0.02152617648243904,
-0.005524162668734789,
0.02549152262508869,
0.02887258306145668,
-0.005894355941563845,
-0.015706742182374,
-0.012237530201673508,
0.004486009944230318,
-0.0035805506631731987,
-0.012591032311320305,
-0.006412937305867672,
-0.0063645318150520325,
0.008934992365539074,
0.023359820246696472,
0.013777056708931923,
-0.012984812259674072,
0.025066539645195007,
-0.010944711975753307,
0.014752577990293503,
-0.0074418457224965096,
-0.019688431173563004,
0.02068619430065155,
0.007823414169251919,
0.013384482823312283,
-0.015332016162574291,
0.017606452107429504,
-0.022188208997249603,
0.024427346885204315,
-0.039238061755895615,
-0.0025267498567700386,
-0.06642109155654907,
0.0043245283886790276,
0.010371544398367405,
0.00003308244049549103,
-0.006456858478486538,
0.003879373660311103,
0.011267527937889099,
0.007889583706855774,
-0.007884303107857704,
0.012884106487035751,
-0.04016547650098801,
-0.009635435417294502,
0.01546178013086319,
-0.011440178379416466,
0.017313892021775246,
0.009272122755646706,
0.011696947738528252,
0.01946420967578888,
0.016142427921295166,
-0.006020801141858101,
-0.03482316806912422,
-0.018904097378253937,
-0.012768066488206387,
0.030142730101943016,
-0.03629819303750992,
-0.0009641272481530905,
0.012117849662899971,
0.00878089852631092,
-0.017885984852910042,
-0.03572574257850647,
0.0344042107462883,
-0.02146548219025135,
0.018627513200044632,
-0.013953089714050293,
-0.002311305608600378,
-0.023791182786226273,
0.003300802316516638,
0.023981377482414246,
-0.008761212229728699,
-0.004994201473891735,
0.019539296627044678,
0.019782377406954765,
-0.03983139991760254,
0.022029947489500046,
0.01616150513291359,
-0.01628762111067772,
0.014965655282139778,
-0.030085396021604538,
0.03379164636135101,
0.00008552544750273228,
0.033418986946344376,
-0.019880397245287895,
0.016966551542282104,
0.01653376780450344,
-0.021943464875221252,
-0.0038809063844382763,
0.03621166944503784,
0.01559289451688528,
0.0017382418736815453,
0.009852906689047813,
-0.009902027435600758,
-0.03607197105884552,
0.015584664419293404,
0.005370951257646084,
0.005003500729799271,
-0.012806685641407967,
0.01560504361987114,
0.0043797302059829235,
0.0002917051315307617,
-0.00040937773883342743,
-0.002720749704167247,
-0.023299891501665115,
0.005470903590321541,
-0.005876106210052967,
-0.00633915513753891,
0.006872539408504963,
0.009844353422522545,
0.0039549944922327995,
0.011359751224517822,
0.03293680027127266,
-0.001094737323001027,
-0.010851847939193249,
0.0027616105508059263,
0.05554208904504776,
-0.015841573476791382,
0.006379607133567333,
-0.01383721549063921,
-0.038922324776649475,
-0.020291004329919815,
0.005233697593212128,
0.041323624551296234,
-0.005680451635271311,
-0.009334171190857887,
-0.002805011346936226,
-0.004943010397255421,
0.02128482609987259,
-0.0019153757020831108,
0.03117990493774414,
0.010587640106678009,
0.01397765427827835,
0.006597471423447132,
-0.006079073064029217,
0.0011590176727622747,
-0.015563479624688625,
0.012110570445656776,
-0.010918276384472847,
0.011914833448827267,
0.00694477092474699,
0.007258676923811436,
-0.011270138435065746,
-0.005104352254420519,
0.0037498152814805508,
0.010373497381806374,
-0.032655999064445496,
0.06608739495277405,
0.004103146493434906,
0.02421850897371769,
-0.008116647601127625,
0.01585575006902218,
0.017180565744638443,
-0.018785716965794563,
0.03458508476614952,
-0.0013867842499166727,
-0.010365533642470837,
0.02254742942750454,
0.0439039021730423,
0.04248298704624176,
-0.001845470629632473,
0.011478632688522339,
-0.003755936399102211,
0.0027366559952497482,
-0.01950279250741005,
0.010007819160819054,
0.009066491387784481,
-0.02822330966591835,
0.025346789509058,
0.007953889667987823,
0.05066573619842529,
0.01458977535367012,
0.0035986455623060465,
0.018023323267698288,
0.019420601427555084,
-0.011690686456859112,
-0.02968427911400795,
0.011423241347074509,
0.01655474677681923,
-0.0026068980805575848,
-0.020651444792747498,
-0.010435772128403187,
0.007923102006316185,
0.019015338271856308,
0.026088660582900047,
0.02481953054666519,
-0.014083294197916985,
-0.017245594412088394,
0.004051404073834419,
-0.0053675537928938866,
-0.014582809992134571,
-0.0005931840278208256,
0.022077716886997223,
-0.00385315902531147,
-0.01565382443368435,
0.012883780524134636,
-0.018654251471161842,
-0.01025668065994978,
-0.016352659091353416,
-0.007413526996970177,
-0.014988629147410393,
-0.009598467499017715,
0.025942277163267136,
0.01994619145989418,
0.015150614082813263,
-0.018885573372244835,
0.023492995649576187,
-0.012273293919861317,
-0.014390365220606327,
0.009346084669232368,
0.027500443160533905,
-0.014241799712181091,
-0.003689688863232732,
0.019467424601316452,
0.019152704626321793,
0.01471009198576212,
-0.01126230787485838,
-0.004849869757890701,
0.0074036275036633015,
-0.011511329561471939,
0.00918365828692913,
-0.0003924872726202011,
0.0180156659334898,
0.00250536622479558,
0.020712407305836678,
0.01645909622311592,
0.025254927575588226,
-0.01863059401512146,
0.007199278101325035,
0.01095893606543541,
-0.0078080445528030396,
-0.016706105321645737,
0.015047835186123848,
0.0048086862079799175,
0.0015478897839784622,
0.028432197868824005,
0.007448730990290642,
-0.028689883649349213,
0.012492340989410877,
-0.012477556243538857,
-0.007125969044864178,
-0.08022013306617737,
-0.01455273013561964,
0.017788799479603767,
-0.027817849069833755,
0.009789155796170235,
0.007658075541257858,
-0.002784021431580186,
0.0012591341510415077,
-0.01519706193357706,
0.010169293731451035,
0.012334320694208145,
0.0028650499880313873,
-0.013658801093697548,
-0.007861705496907234,
-0.02627510018646717,
-0.01284128986299038,
0.011033205315470695,
-0.009946461766958237,
-0.006465030834078789,
-0.018062690272927284,
-0.002786677796393633,
-0.0123220169916749,
-0.00015077553689479828,
0.02791699580848217,
0.003091096878051758,
-0.013720547780394554,
0.012593714520335197,
-0.01428049523383379,
-0.02125583402812481,
0.004807775840163231,
-0.01822090521454811,
-0.010987612418830395,
0.04698936641216278,
-0.00007981900125741959,
-0.019472043961286545,
0.011072186753153801,
-0.011458688415586948,
0.010928758420050144,
-0.004794995300471783,
-0.010977483354508877,
-0.003521587233990431,
0.015532195568084717,
0.01522839441895485,
0.0027664361987262964,
0.0004600854590535164,
0.004266609437763691,
-0.04128746688365936,
0.049476172775030136,
0.020787417888641357,
-0.013227775692939758,
0.010763985104858875,
0.008918975479900837,
0.02981877513229847,
0.017369257286190987,
-0.01970895379781723,
0.02159007266163826,
-0.01790674775838852,
0.022776097059249878,
-0.011732644401490688,
-0.016016095876693726,
0.021999314427375793,
-0.03397829458117485,
-0.04121239483356476,
-0.0034881141036748886,
0.034667279571294785,
0.007382321171462536,
0.003329850733280182,
-0.037155378609895706,
-0.023379985243082047,
0.021852847188711166,
0.023563671857118607,
-0.0288406815379858,
0.017344342544674873,
-0.0008763640653342009,
-0.005733603611588478,
-0.015087854117155075,
-0.016193676739931107,
0.0008274168940261006,
0.01240253634750843,
-0.014742028899490833,
-0.008637980557978153,
-0.005742487497627735,
-0.012155625969171524,
0.009594574570655823,
-0.028147142380475998,
-0.029324263334274292,
0.009505636990070343,
0.010797166265547276,
0.022992026060819626,
-0.014885997399687767,
0.018933242186903954,
0.0225320216268301,
0.02009652927517891,
0.012033332139253616,
-0.02674327790737152,
-0.013167732395231724,
0.0014236136339604855,
-0.011730430647730827,
0.016172543168067932,
0.011768867261707783,
-0.015133282169699669,
0.007888298481702805,
0.04588286578655243,
-0.012826746329665184,
-0.021925102919340134,
0.012335984036326408,
-0.009006241336464882,
0.011922342702746391,
0.007252522278577089,
-0.00037902785697951913,
-0.012653360143303871,
-0.04095720127224922,
-0.008317394182085991,
0.018781129270792007,
0.01779232732951641,
-0.0053270491771399975,
-0.01961475983262062,
0.021508008241653442,
0.07146258652210236,
-0.005199382081627846,
0.014442944899201393,
-0.013739711605012417,
0.026040958240628242,
-0.04345492273569107,
0.013600812293589115,
0.0009328818414360285,
-0.01477489247918129,
-0.01605513133108616,
0.013216985389590263,
0.0010211914777755737,
-0.0007618744857609272,
0.009940790943801403,
-0.017703883349895477,
0.011345846578478813,
-0.02209792099893093,
-0.013606388121843338,
-0.01820679008960724,
-0.01518147625029087,
0.0015834085643291473,
-0.010200772434473038,
-0.025987228378653526,
0.015429960563778877,
-0.00900362804532051,
-0.01772785559296608,
-0.01805923692882061,
-0.017310548573732376,
-0.01655876636505127,
0.01868331804871559,
0.0347537025809288,
-0.03577478229999542,
-0.006854865700006485,
0.014312410727143288,
0.020097248256206512,
0.027535047382116318,
0.0610903799533844,
0.018277693539857864,
-0.004290634300559759,
0.004980247467756271,
-0.005618319846689701,
-0.015367772430181503,
0.017677396535873413,
0.007696794345974922,
-0.011430671438574791,
0.01872008852660656,
0.010583549737930298,
-0.00714066531509161,
-0.010391851887106895,
-0.003984571434557438,
-0.012234920635819435,
-0.022821851074695587,
0.020256366580724716,
0.020420022308826447,
0.01731777936220169,
0.04052635282278061,
0.01453628484159708,
0.009956996887922287,
0.00935970526188612,
-0.017876621335744858,
-0.057414550334215164,
0.006681898143142462,
0.030825652182102203,
0.0038626324385404587,
0.01401278842240572,
-0.010739408433437347,
-0.010026302188634872,
-0.015012426301836967,
-0.009613750502467155,
-0.011981785297393799,
0.0007609640015289187,
-0.044261716306209564,
-0.027409322559833527,
-0.017223846167325974,
-0.02963104471564293,
-0.021402832120656967,
-0.0022665481083095074,
0.026119140908122063,
-0.00904473103582859,
-0.010599406436085701,
-0.00469563715159893,
0.015691081061959267,
0.0003719525411725044,
0.04022620618343353,
-0.0003974481951445341,
0.00410996749997139,
-0.032192204147577286,
-0.07428259402513504,
0.005720699205994606,
-0.01769942231476307,
-0.008253375068306923,
-0.007079055067151785,
0.015158274210989475,
-0.011345346458256245,
0.025452863425016403,
0.02135210484266281,
-0.007910449057817459,
0.011294715106487274,
-0.004772219806909561,
-0.01597604528069496,
-0.020438726991415024,
0.01277448795735836,
0.03757259249687195,
-0.013501410372555256,
-0.006530854385346174,
-0.01568872109055519,
0.037900302559137344,
-0.005901881493628025,
-0.007778601720929146,
-0.030318688601255417,
-0.008319869637489319,
-0.012938027270138264,
-0.08048740774393082,
0.011940078809857368,
-0.023390168324112892,
-0.046925172209739685,
-0.006713756825774908,
-0.040201060473918915,
0.03039369359612465,
0.00034852392855100334,
-0.015733689069747925,
-0.01436932384967804,
-0.012888574972748756,
-0.006130228750407696,
0.001870124600827694,
-0.013754433020949364,
0.007036332041025162,
-0.0029214750975370407,
0.02004285715520382,
0.0138695128262043,
-0.016315212473273277,
-0.01847502775490284,
-0.016762297600507736,
0.005834956653416157,
-0.010903333313763142,
-0.003739987500011921,
-0.007392627187073231,
-0.03959885239601135,
-0.0044741323217749596,
0.013652035966515541,
0.00017185998149216175,
0.012282161973416805,
0.013659713789820671,
-0.007924629375338554,
-0.010321597568690777,
-0.019700728356838226,
-0.02948324754834175,
-0.03545777499675751,
0.009122384712100029,
-0.026009883731603622,
0.02437598630785942,
-0.007245845161378384,
-0.0075669242069125175,
0.0005201500607654452,
-0.003940238617360592,
0.03126734122633934,
0.007991358637809753,
-0.03436332195997238,
0.005985495634377003,
-0.009134339168667793,
-0.00013616611249744892,
0.03360820561647415,
0.006336447317153215,
-0.0038322482723742723,
0.046250857412815094,
-0.003024822799488902,
-0.023747518658638,
0.01212204061448574,
-0.013015449047088623,
0.027439115568995476,
-0.00043591391295194626,
0.004872428253293037,
-0.015838924795389175,
0.029221246019005775,
0.005128932651132345,
0.07119032740592957,
-0.04455173760652542,
0.018615910783410072,
-0.006442843470722437,
0.0002679028548300266,
0.0033561796881258488,
-0.046065375208854675,
-0.020196497440338135,
-0.008072417229413986,
-0.011760992929339409,
0.021175255998969078,
-0.014334364794194698,
0.014821961522102356,
0.011577208526432514,
-0.00020687619689852,
-0.0097736157476902,
-0.020624905824661255,
0.008935026824474335,
-0.030541112646460533,
0.014255942776799202,
0.03586779907345772,
0.007615082897245884,
-0.04303305596113205,
-0.0005650692619383335,
-0.00907869078218937,
-0.004338925238698721,
-0.01726260967552662,
-0.010706929489970207,
0.008159598335623741,
-0.00745309516787529,
0.004187361337244511,
-0.010300420224666595,
0.004462908022105694,
0.023721784353256226,
0.012957137078046799,
0.010179178789258003,
-0.016115058213472366,
0.005574424751102924,
0.0029345680959522724,
-0.003202010877430439,
0.0002877619117498398,
0.012018248438835144,
-0.002214430132880807,
-0.03107604756951332,
0.013826262205839157,
-0.009738563559949398,
-0.028726166114211082,
0.0041071888990700245,
0.016631510108709335,
0.00926121138036251,
0.04195726662874222,
0.008968153968453407,
0.03381774201989174,
-0.004034713841974735,
-0.01073422096669674,
0.015991894528269768,
0.012658683583140373,
0.01124422438442707,
0.02894013002514839,
-0.013031079433858395,
0.019454555585980415,
-0.008977659046649933,
-0.04065825045108795,
-0.009497568011283875,
0.020882975310087204,
0.005726300645619631,
-0.01233692653477192,
-0.018260221928358078,
0.015584140084683895,
0.021360250189900398,
0.007163159549236298,
0.005357922986149788,
0.014053553342819214,
-0.01615755632519722,
0.0008025007555261254,
-0.006594356615096331,
0.030970117077231407,
-0.000547400675714016,
0.003485672641545534,
0.015480922535061836,
-0.00900261290371418,
0.03560929000377655,
-0.0014001952949911356,
0.010958690196275711,
-0.02736993506550789,
0.0026254598051309586,
-0.011102204211056232,
-0.012156499549746513,
-0.006851749494671822,
0.014056630432605743,
0.04718030244112015,
0.0203015748411417,
-0.000367842148989439,
-0.0020993277430534363,
0.006020165979862213,
0.03435260057449341,
-0.0008472404442727566,
0.007868594489991665,
-0.04087308049201965,
0.029044726863503456,
0.036525025963783264,
0.028025157749652863,
-0.021655255928635597,
-0.03395739942789078,
-0.009043851867318153,
-0.0009710427839308977,
0.0026559995021671057,
0.04411504790186882,
-0.014780162833631039,
0.033024728298187256,
0.008523738011717796,
0.026656880974769592,
0.010878284461796284,
-0.011528627946972847,
-0.003130961675196886,
0.010958220809698105,
-0.0023328070528805256,
0.00850158091634512,
-0.017610087990760803,
-0.016323503106832504,
-0.007547944784164429,
-0.003936391789466143,
-0.022351644933223724,
0.007641524076461792,
0.019468434154987335,
-0.013109623454511166,
-0.006166588515043259,
0.002501734532415867,
-0.003757000435143709,
0.029894497245550156,
0.026770595461130142,
-0.0009806398302316666,
0.007086311932653189,
-0.02687680907547474,
0.009593810886144638,
0.0001707104966044426,
-0.04137268289923668,
0.009217831306159496,
-0.0021010898053646088,
-0.014904862269759178,
0.02500029094517231,
-0.00896487757563591,
-0.0020204747561365366,
0.01218825951218605,
0.00862337090075016,
-0.01122875977307558,
0.015179984271526337,
0.025056717917323112,
0.0036280816420912743,
-0.012927688658237457,
0.017561443150043488,
0.016031166538596153,
-0.004561883397400379,
-0.01083865575492382,
0.003242171835154295,
0.03155219182372093,
0.0033335466869175434,
-0.02695276588201523,
-0.033855147659778595,
0.007944509387016296,
-0.011773166246712208,
0.015859324485063553,
-0.005184301640838385,
-0.014251237735152245,
0.008083082735538483,
0.040832262486219406,
-0.03650845214724541,
0.01029528770595789,
-0.0368538498878479,
0.001014381879940629,
0.01383874099701643,
-0.0047966125421226025,
-0.027015656232833862,
0.006629912182688713,
-0.038241609930992126,
-0.007485523819923401,
-0.017908047884702682,
0.008650332689285278,
-0.031138479709625244,
-0.017043743282556534,
0.00443622749298811,
0.00578860379755497,
0.01058101188391447,
-0.015074113383889198,
0.007509483490139246,
0.0035546566359698772,
-0.01405957993119955,
-0.01532896887511015,
0.02293539047241211,
0.008948408998548985,
0.007768532261252403,
-0.01877523772418499,
-0.024298805743455887,
-0.007983089424669743,
0.0038052531890571117,
-0.018352122977375984,
0.0020941970869898796,
0.012675979174673557,
0.0020356103777885437,
-0.0016048126854002476,
0.011474836617708206,
-0.028206832706928253
] | [
0.5727289915084839,
0.13540731370449066,
-0.14232125878334045,
0.1778346300125122,
-0.020747674629092216,
-0.02062446065247059,
0.26877322793006897,
-0.3103001117706299,
-0.06280750781297684,
-0.2011367827653885,
0.1365940421819687,
0.2202502191066742,
-0.17518946528434753,
0.38806357979774475,
-0.510414719581604,
0.5527632236480713,
0.4684274196624756,
0.4748431444168091,
-0.162766233086586,
-0.3045525550842285,
-0.43697282671928406,
-0.45797768235206604,
0.3482532799243927,
-0.45062822103500366,
-0.19988135993480682,
0.17426471412181854,
0.8356627821922302,
-0.07702761143445969,
-0.21462875604629517,
0.05150274559855461,
0.03632558882236481,
0.6623271107673645,
0.03954237326979637,
-0.18728430569171906,
-0.27969449758529663,
-0.13911256194114685,
0.05635280907154083,
0.2656269669532776,
-0.08922436833381653,
-0.200819194316864,
-0.0963916927576065,
-0.23942367732524872,
0.09158214926719666,
0.30781182646751404,
-0.11138240247964859,
-0.429853618144989,
-1.6019933223724365,
0.45261165499687195,
-0.18212302029132843,
0.11338376998901367,
-0.134681835770607,
0.14832116663455963,
0.08627932518720627,
0.30586057901382446,
-0.06830599904060364,
0.19643418490886688,
-0.31294479966163635,
-0.36604782938957214,
0.14948613941669464,
-0.26894766092300415,
-0.11891154944896698,
-0.06150873750448227,
-0.19926074147224426,
0.1081986352801323,
0.14733609557151794,
0.492858350276947,
0.0367538146674633,
-0.2574123442173004,
-0.6050410866737366,
-0.1326739490032196,
0.2826254367828369,
-0.5679450631141663,
0.10283013433218002,
0.010461922734975815,
-0.07297009974718094,
0.239110067486763,
-0.3114670515060425,
-0.025341231375932693,
0.5714057087898254,
-0.2776440978050232,
-0.013967546634376049,
-0.23464030027389526,
0.06571412831544876,
0.009748347103595734,
0.5901706218719482,
0.05617957189679146,
0.05806536227464676,
0.5713331699371338,
-0.41776230931282043,
0.24887549877166748,
-0.018403977155685425,
-0.18974988162517548,
0.3780781030654907,
0.36632075905799866,
0.7057536244392395,
0.1383744329214096,
-0.0645144060254097,
-0.26241663098335266,
0.006473852321505547,
0.4112330675125122,
-0.31207823753356934,
-0.025894716382026672,
0.004543251823633909,
-0.11314605176448822,
-0.7492086887359619,
-0.47105973958969116,
-0.07909183204174042,
-0.29085788130760193,
-0.533350944519043,
0.27564793825149536,
-0.36621588468551636,
0.6429123282432556,
-0.1586960107088089,
0.34206417202949524,
-0.5896711945533752,
0.2986851632595062,
0.18548811972141266,
-0.4011704623699188,
0.04428953304886818,
0.1823142021894455,
-0.05785185098648071,
1.5622258186340332,
-0.30994635820388794,
0.07803744077682495,
0.25795233249664307,
0.05482790619134903,
0.44571200013160706,
0.5510997176170349,
-0.2882731556892395,
0.7667021155357361,
-0.20200704038143158,
0.9009073972702026,
-0.22823600471019745,
-0.002609735820442438,
-0.1386273205280304,
-0.5020065903663635,
0.24899625778198242,
0.062483251094818115,
0.5600359439849854,
0.2668973505496979,
-0.2045523077249527,
-0.5497941374778748,
-0.12307056039571762,
0.18069741129875183,
0.179051473736763,
-0.12527069449424744,
-0.1395413875579834,
-0.07860435545444489,
-0.5811684727668762,
-0.17131732404232025,
0.14067478477954865,
0.11010447144508362,
-0.39742311835289,
-0.24979130923748016,
0.10395992547273636,
0.48337799310684204,
-0.19971534609794617,
-0.3975178003311157,
-0.09706009924411774,
0.3284425437450409,
0.208934485912323,
0.3067561388015747,
-0.7766060829162598,
0.15124091506004333,
0.6610183715820312,
-0.49720796942710876,
0.08210477977991104,
0.3345595598220825,
0.13183347880840302,
0.1740970015525818,
-0.25324746966362,
-0.21646113693714142,
-0.06808031350374222,
-0.6451326608657837,
0.28802886605262756,
0.44456687569618225,
0.024282554164528847,
-0.07070820778608322,
0.07819677889347076,
0.5140951871871948,
-0.6471697092056274,
0.13215099275112152,
-0.24080851674079895,
-0.5936568975448608,
0.23975834250450134,
0.08491037786006927,
0.6951640248298645,
0.391832560300827,
-0.24778605997562408,
-0.06674016267061234,
-0.5652557611465454,
-0.547588050365448,
0.9503882527351379,
-0.47024235129356384,
1.6476176977157593,
0.025587378069758415,
-0.02724303863942623,
1.5064473152160645,
0.008924095891416073,
-0.0027704923413693905,
-0.089060939848423,
-0.01158013753592968,
0.21017180383205414,
0.1769755780696869,
-1.0332199335098267,
0.08634090423583984,
0.10320258885622025,
-0.4538128972053528,
-0.35116833448410034,
0.19720633327960968,
0.4334540367126465,
-0.07031115144491196,
-0.22663451731204987,
-0.4812317490577698,
0.03335147351026535,
-0.056801438331604004,
0.2038128823041916,
0.05559507757425308,
-0.3060463070869446,
-0.37978506088256836,
0.3931269943714142,
-0.6380735039710999,
0.5175894498825073,
0.618659257888794,
-0.06346296519041061,
0.4975857734680176,
0.43601682782173157,
0.10150935500860214,
0.7825924158096313,
-0.2537570297718048,
0.1267922967672348,
-0.2503904700279236,
0.7428144216537476,
-0.35166803002357483,
-0.22367210686206818,
0.52860426902771,
0.18684305250644684,
0.04362413287162781,
-0.09083007276058197,
0.25325220823287964,
-0.2873530685901642,
0.4258491098880768,
-0.724208414554596,
0.34585994482040405,
-0.2561025619506836,
-0.38412415981292725,
-0.40771034359931946,
0.35303938388824463,
-0.8141584992408752,
-0.1315339207649231,
0.2128916084766388,
0.33119359612464905,
0.12436181306838989,
-0.50774747133255,
-0.07502885907888412,
0.39962685108184814,
-0.10492759943008423,
-0.5125941038131714,
0.0315273143351078,
-0.25659650564193726,
-0.13563022017478943,
0.4370875954627991,
-0.2061774879693985,
0.18145693838596344,
0.013764786534011364,
-0.405540406703949,
-0.6757050156593323,
-0.47639185190200806,
0.9421472549438477,
0.6891474723815918,
0.3656896650791168,
-0.0025778189301490784,
-0.9352023601531982,
0.14422670006752014,
-0.1599012166261673,
-0.6744896173477173,
-0.3860020339488983,
0.5579359531402588,
-0.3348660171031952,
-0.2837643325328827,
-0.24631185829639435,
0.3574892580509186,
0.9445425271987915,
-0.11370862275362015,
-0.41530847549438477,
-0.12260611355304718,
0.10757283866405487,
-0.2049182653427124,
-0.7627044916152954,
-0.18531392514705658,
-0.17661234736442566,
0.5675854682922363,
-0.2527792751789093,
-0.4400264322757721,
0.05514570698142052,
0.46065986156463623,
0.02482682093977928,
0.17056316137313843,
0.5967611074447632,
0.012190141715109348,
-0.21038725972175598,
0.28487899899482727,
0.16299083828926086,
-0.34771406650543213,
-0.11727205663919449,
-0.20794150233268738,
-0.18530525267124176,
0.12232431769371033,
-6.028889179229736,
-0.22803199291229248,
-0.3176012337207794,
-0.05102165788412094,
-0.564004123210907,
-0.22960211336612701,
1.1152682304382324,
-0.294377863407135,
0.0826263278722763,
-0.0709099993109703,
-0.02058817446231842,
0.7144122123718262,
0.15307897329330444,
0.007626784034073353,
0.3345160484313965,
0.14069661498069763,
-0.006672813091427088,
-0.44220295548439026,
0.8385351896286011,
0.2485053390264511,
0.3126758933067322,
0.2117956280708313,
0.09039977192878723,
0.5929732322692871,
0.01249143946915865,
0.5517144799232483,
-1.0318105220794678,
0.46659448742866516,
-0.07367090880870819,
-0.5421575903892517,
0.36486995220184326,
-0.37106838822364807,
-0.32441163063049316,
-0.29277458786964417,
-0.03798134624958038,
0.22380569577217102,
0.08446894586086273,
0.11031210422515869,
-0.10645109415054321,
-0.1814819574356079,
0.48050931096076965,
0.2241148054599762,
-0.2345045804977417,
0.11440525949001312,
0.1563073694705963,
0.14902840554714203,
-0.18759383261203766,
-0.06268841028213501,
-0.2781355082988739,
0.7748080492019653,
-0.18808819353580475,
-0.2046235203742981,
0.5264843106269836,
0.5701131820678711,
-0.10115037858486176,
-0.02666836604475975,
-0.04230831563472748,
0.16178201138973236,
-0.5947089195251465,
-0.1589045524597168,
-0.25550293922424316,
-0.3603963553905487,
-0.1440279334783554,
-0.7680181860923767,
0.049493517726659775,
0.09024276584386826,
-0.6548737287521362,
-0.42110082507133484,
-0.009121295064687729,
-0.1208854466676712,
-0.34095481038093567,
0.3140941858291626,
0.1635955274105072,
-0.5111145973205566,
0.5501863956451416,
-0.5160449147224426,
-0.24183225631713867,
-0.12290611863136292,
-0.1942061483860016,
-0.017868073657155037,
-0.26750707626342773,
-0.12185798585414886,
-0.0006814697990193963,
0.13227863609790802,
0.09346868097782135,
-0.8433002829551697,
-0.22806644439697266,
0.0340975746512413,
-0.18514207005500793,
0.17027366161346436,
0.21970009803771973,
0.05470047891139984,
0.05772297456860542,
0.5626969337463379,
0.5704363584518433,
0.6732258200645447,
0.5466989278793335,
0.4155861437320709,
0.3231010138988495,
-0.013939850963652134,
0.5253942012786865,
0.14051055908203125,
-0.2483556717634201,
-1.2896567583084106,
-0.13854189217090607,
0.11148460954427719,
-0.4649299085140228,
-0.09203825891017914,
0.48095983266830444,
-0.8728022575378418,
0.050258077681064606,
-0.0624222494661808,
-0.3833748996257782,
-0.12090620398521423,
0.23873810470104218,
-0.10010699182748795,
0.07194708287715912,
0.0671786442399025,
0.5206089019775391,
-0.14089839160442352,
0.30784767866134644,
-0.026804354041814804,
-0.2208731472492218,
0.3744739592075348,
-0.06735071539878845,
-0.5895611643791199,
0.44235143065452576,
0.7838775515556335,
-0.47030699253082275,
0.13661329448223114,
0.5879368782043457,
0.32058918476104736,
-0.4579125642776489,
-0.39525848627090454,
0.3713260591030121,
-0.17698635160923004,
-0.471855491399765,
0.3100326657295227,
0.006524614989757538,
-0.32758036255836487,
0.21428242325782776,
-0.09927606582641602,
-0.19818079471588135,
0.6596558094024658,
0.12884783744812012,
0.018327917903661728,
0.1643899381160736,
-0.12149069458246231,
-0.017460644245147705,
-0.12985444068908691,
-0.41966432332992554,
-0.2807694375514984,
0.2130356729030609,
-0.33737272024154663,
0.3111855983734131,
0.3882850706577301,
0.689720630645752,
0.233047753572464,
-0.2589549124240875,
-0.4565761685371399,
-0.0978596955537796,
0.3609379529953003,
-0.9544326066970825,
0.07666312158107758,
0.042944617569446564,
-0.42905548214912415,
-0.1850920021533966,
-0.31082314252853394,
-0.08937721699476242,
0.13900603353977203,
-0.32360124588012695,
-0.17551486194133759,
-0.06234404072165489,
-0.010884280316531658,
0.07807757705450058,
0.13205277919769287,
0.0010102676460519433,
0.3365173041820526,
-0.07291018962860107,
0.23333217203617096,
-0.03130482882261276,
-0.524484395980835,
-0.12854039669036865,
0.4510089159011841,
0.8934454917907715,
0.4196522831916809,
-0.21320423483848572,
0.0752272680401802,
-0.4284152388572693,
-0.003034779103472829,
0.03881746903061867,
0.3089961111545563,
0.5096209645271301,
0.1515006273984909,
-0.4359108507633209,
-0.18296164274215698,
-0.10572370141744614,
0.14410027861595154,
0.21989735960960388,
-0.36455854773521423,
0.07224058359861374,
0.5900710821151733,
-0.40501683950424194,
0.33888810873031616,
0.1912873387336731,
-0.34070801734924316,
0.2655586898326874,
0.288583904504776,
-0.6108869910240173,
-0.032111555337905884,
-0.1926124095916748,
-0.578445553779602,
0.11356893181800842,
0.5172721147537231,
-0.18649835884571075,
-0.1627883017063141,
-0.029481885954737663,
0.08489625155925751,
-0.44198405742645264,
0.4856201708316803,
0.36200186610221863,
-0.374718576669693,
-0.2855378985404968,
0.012561357580125332,
-0.42651450634002686,
-0.1872752606868744,
0.5081362724304199,
-0.9843862652778625,
-0.03908554092049599,
0.20672360062599182,
-0.36167556047439575,
-0.11566881835460663,
0.527654230594635,
0.16253039240837097,
-0.5907413959503174,
-0.14857317507266998,
-0.3690382242202759,
0.4062739908695221,
-0.13358908891677856,
0.1513647586107254,
0.027579806745052338,
0.09997030347585678,
-0.4831317961215973,
-0.3407175540924072,
-0.061154529452323914,
0.29210346937179565,
0.1626930981874466,
-0.2221216857433319,
-0.7283442616462708,
0.2993733286857605,
0.47946876287460327,
-0.2519688904285431,
-0.11553499102592468,
0.13884325325489044,
0.9014012217521667,
0.5761773586273193,
-0.21455137431621552,
-0.7225466966629028,
-0.1399911493062973,
0.3532320261001587,
-0.13728506863117218,
-0.1907455325126648,
-0.08928066492080688,
-0.42655709385871887,
0.1143956333398819,
0.0007348423241637647,
-0.09866702556610107,
-0.8476139307022095,
0.23831790685653687,
-0.25074660778045654,
0.11283658444881439,
0.13925617933273315,
0.789649486541748,
0.5996030569076538,
-0.00434925127774477,
0.030017590150237083,
-0.45021700859069824,
0.20671816170215607,
-0.2120523899793625,
0.3075021207332611,
-0.1568303406238556,
-0.6684392690658569,
0.12838223576545715,
-0.1626441478729248,
0.1551235318183899,
-0.1105867549777031,
0.48521706461906433,
-0.014213025569915771,
0.4235261082649231,
-0.43655329942703247,
-0.2938550114631653,
-0.055892594158649445,
-0.8841344714164734,
-0.36425742506980896,
0.10546589642763138,
0.07521786540746689,
0.34663909673690796,
0.18353839218616486,
-0.05513882637023926,
-0.38791796565055847,
-0.3808475136756897,
0.36418694257736206,
0.7818764448165894,
-0.3846760392189026,
0.31013238430023193,
0.5359818935394287,
0.122723788022995,
-0.016637248918414116,
0.17861461639404297,
0.03570374846458435,
0.20465002954006195,
-0.15910576283931732,
0.23464122414588928,
0.27067530155181885,
-0.22139272093772888,
-0.02531953528523445,
-0.2407323271036148,
0.03640394285321236,
0.5111217498779297,
0.2885253429412842,
0.27187380194664,
0.34098806977272034,
0.5636405348777771,
-0.1497742384672165,
-0.45654767751693726,
0.30491527915000916,
-0.06397883594036102,
0.22605042159557343,
0.2873479723930359,
0.35011377930641174,
0.49021241068840027,
0.7340397238731384,
0.0198618583381176,
0.028453020378947258,
0.05990628898143768,
0.17340777814388275,
0.19968654215335846,
-0.28545212745666504,
-0.2899210751056671,
0.2509106993675232,
0.6372025609016418,
0.1152181625366211,
-0.28291457891464233,
-0.2302442491054535,
-0.17286944389343262,
0.32577574253082275,
0.11955124139785767,
0.4353847801685333,
-0.22476305067539215,
0.11943560838699341,
-0.15303334593772888,
0.10278141498565674,
-0.5956310629844666,
0.39926615357398987,
-0.34281671047210693,
-0.03193598985671997,
0.46507105231285095,
-0.2523268461227417,
-0.5621397495269775,
0.2931402921676636,
-0.33936503529548645,
0.2150515913963318,
-0.9586869478225708,
0.5004278421401978,
-0.19902712106704712,
0.14664702117443085,
0.5810426473617554,
0.095926433801651,
0.21976065635681152,
-0.3204036355018616,
0.11195167899131775,
-0.17440548539161682,
-0.1010015681385994,
0.39762014150619507,
-0.09138128161430359,
-0.5667203068733215,
0.27928614616394043,
-0.11167559027671814,
-0.3361722528934479,
0.3378244638442993,
-0.20176488161087036,
0.306454062461853,
0.13713158667087555,
-0.39040234684944153,
0.10884407162666321,
-0.3923840820789337,
-0.3986937701702118,
0.0389004610478878,
0.12389896810054779,
-0.10229068994522095,
-0.06334640085697174,
-0.9701941609382629,
-0.08945523947477341,
-0.029706958681344986,
-0.2850229740142822,
-0.1514185220003128,
0.01726342923939228,
0.3851346969604492,
0.2532348930835724,
0.16739009320735931,
-0.5390268564224243,
0.10155164450407028,
0.013092480599880219,
0.7015358209609985,
-0.6117860078811646,
0.3786281645298004,
-0.4381929636001587,
-0.1854010820388794,
-0.7859510183334351,
-0.01482485979795456,
0.8119254112243652,
0.38315725326538086,
-0.2382439821958542,
-0.014094767160713673,
-0.07771884649991989,
0.18687763810157776,
0.17553620040416718,
-0.5186807513237,
-0.10797694325447083,
-0.29835453629493713,
-0.4089010953903198,
-0.5283374786376953,
0.43522903323173523,
-0.1321481615304947,
-0.1267373263835907,
-0.1565374732017517,
0.3617544174194336,
0.42061418294906616,
-0.14722397923469543,
0.26917535066604614,
-0.20211993157863617,
-0.09797701239585876,
-0.3243462145328522,
0.4794482886791229,
-0.3549788296222687,
0.20611022412776947,
0.015967056155204773,
0.10110312700271606,
0.14510492980480194,
-0.24463801085948944,
-0.1659603863954544,
-0.5053051710128784,
-0.0996459573507309,
0.3415609896183014,
0.08965819329023361,
0.6642389297485352,
-0.053529784083366394,
-0.40745702385902405,
-0.6390057802200317,
0.044808726757764816,
-0.216413214802742,
0.00990399532020092,
-0.39379996061325073,
-0.29832035303115845,
0.03986349329352379,
0.14695803821086884,
-0.12825612723827362,
-0.3402867913246155,
-0.26867929100990295,
0.1124245896935463
] |
Mitochondrial transport is crucial for neuronal and axonal physiology. However, whether and how it impacts neuronal injury responses, such as neuronal survival and axon regeneration, remain largely unknown. In an established mouse model with robust axon regeneration, we show that Armcx1, a mammalian-specific gene encoding a mitochondria-localized protein, is upregulated after axotomy in this high regeneration condition. Armcx1 overexpression enhances mitochondrial transport in adult retinal ganglion cells (RGCs). Importantly, Armcx1 also promotes both neuronal survival and axon regeneration after injury, and these effects depend on its mitochondrial localization. Furthermore, Armcx1 knockdown undermines both neuronal survival and axon regeneration in the high regenerative capacity model, further supporting a key role of Armcx1 in regulating neuronal injury responses in the adult central nervous system (CNS). Our findings suggest that Armcx1 controls mitochondrial transport during neuronal repair. | [
-0.005916088353842497,
0.015810126438736916,
-0.020409677177667618,
0.012282055802643299,
0.007092291489243507,
-0.05984441190958023,
0.011723745614290237,
-0.0005894897039979696,
-0.010032149963080883,
-0.02498958632349968,
-0.010256864130496979,
0.01785842701792717,
-0.007111615035682917,
0.02064506895840168,
-0.0008200532756745815,
0.04300139099359512,
-0.029703568667173386,
0.032834187150001526,
0.019498908892273903,
-0.011368260718882084,
-0.02860935404896736,
0.009813142940402031,
0.011807406321167946,
-0.024101296439766884,
0.036085691303014755,
0.016618091613054276,
0.006311733741313219,
0.021602552384138107,
-0.016549572348594666,
-0.008503411896526814,
-0.001672531245276332,
0.037281330674886703,
-0.001858556643128395,
-0.006240614224225283,
0.010397189296782017,
0.008009790442883968,
-0.008138568140566349,
0.03796377778053284,
0.03662395849823952,
-0.004721737466752529,
0.014724016189575195,
-0.01212899386882782,
0.005268966779112816,
0.013122089207172394,
-0.010179500095546246,
-0.010362512432038784,
0.0030352994799613953,
0.029192611575126648,
-0.018280576914548874,
0.005726628936827183,
-0.00150996632874012,
-0.03440367430448532,
-0.0025619245134294033,
0.028041251003742218,
-0.007503476459532976,
0.005293297581374645,
0.01819239743053913,
-0.013615238480269909,
0.018880300223827362,
-0.005125647410750389,
0.0016942252404987812,
-0.0003224373795092106,
-0.010732712224125862,
-0.05278925970196724,
0.0032586664892733097,
-0.06639894843101501,
0.009762312285602093,
0.018204692751169205,
-0.0026088724844157696,
0.02104935795068741,
-0.013264941051602364,
0.009051544591784477,
0.01720106042921543,
-0.018600426614284515,
-0.011629668064415455,
-0.015148591250181198,
-0.019183997064828873,
0.022319942712783813,
0.010874178260564804,
0.012824881821870804,
-0.004052051808685064,
-0.0048397378996014595,
0.013865198008716106,
0.02934303693473339,
0.014677952975034714,
-0.0016814323607832193,
-0.024317434057593346,
-0.011324217543005943,
0.018768157809972763,
0.004371498711407185,
0.006313949357718229,
0.00005784817039966583,
-0.016860835254192352,
-0.012988585978746414,
-0.03953953832387924,
0.0005898044910281897,
-0.012264578603208065,
0.01203405112028122,
-0.010843459516763687,
-0.006754857487976551,
0.00024384353309869766,
0.02970867231488228,
0.016658928245306015,
0.010643149726092815,
-0.005043674260377884,
0.007117179222404957,
-0.009153562597930431,
-0.01611800119280815,
0.04834458976984024,
0.017537593841552734,
0.010212085209786892,
0.0010175078641623259,
-0.023889612406492233,
0.027795027941465378,
-0.01528678834438324,
0.0038062429521232843,
-0.011194020509719849,
0.010858550667762756,
0.010331692174077034,
0.0057192714884877205,
-0.0026956889778375626,
0.006099591962993145,
-0.003961948212236166,
-0.013167307712137699,
-0.0005695990985259414,
0.00922410748898983,
0.008792693726718426,
0.005944353528320789,
-0.002594355493783951,
0.003062034724280238,
-0.010297521948814392,
0.013710331171751022,
0.013937978073954582,
0.005778580904006958,
0.0006992763374000788,
0.0021751034073531628,
-0.04288564249873161,
-0.01441001147031784,
0.002944391453638673,
-0.009463172405958176,
0.030449463054537773,
0.010116489604115486,
-0.0006802385905757546,
0.016134221106767654,
0.017821935936808586,
0.0002672336995601654,
0.01117407064884901,
0.016908463090658188,
-0.009401223622262478,
-0.019039005041122437,
-0.007459327578544617,
0.021095795556902885,
0.013407290913164616,
-0.01364897657185793,
0.016386330127716064,
0.0005451494362205267,
-0.023120325058698654,
-0.03813246637582779,
-0.0005333402659744024,
0.0261507797986269,
-0.03498098626732826,
-0.029323004186153412,
0.02011958882212639,
0.010957138612866402,
-0.004330237861722708,
-0.017095640301704407,
0.031582921743392944,
-0.02118547074496746,
-0.018851198256015778,
0.008839165791869164,
-0.0017334634903818369,
0.009790854528546333,
-0.005690515041351318,
0.007477788254618645,
0.0007980922237038612,
0.003651496022939682,
-0.0021640188060700893,
0.008604020811617374,
0.001871588290669024,
0.06631413847208023,
0.011202149093151093,
0.016102030873298645,
0.014408476650714874,
0.010055765509605408,
-0.006398641504347324,
-0.010164407081902027,
0.026726502925157547,
-0.0036785791162401438,
0.014628369361162186,
-0.03038027137517929,
-0.005094463471323252,
0.016467804089188576,
-0.03281209245324135,
0.020757094025611877,
-0.02481062337756157,
0.0030826672445982695,
-0.00017245113849639893,
0.005943605676293373,
0.004106454085558653,
-0.010574946179986,
0.015224779024720192,
-0.03806567192077637,
0.008499783463776112,
-0.03417935594916344,
0.011116934940218925,
0.00885571539402008,
0.011222144588828087,
-0.011951328255236149,
0.0020134723745286465,
-0.021159455180168152,
0.01999008283019066,
-0.0034793922677636147,
-0.029957562685012817,
-0.0018412028439342976,
0.008941898122429848,
0.005017565563321114,
-0.013839803636074066,
0.023907463997602463,
0.022259872406721115,
-0.012446350418031216,
-0.0009854576783254743,
0.012133540585637093,
-0.022199856117367744,
-0.00040368642657995224,
0.017301950603723526,
0.027992360293865204,
-0.014133693650364876,
0.011719873175024986,
-0.007567387539893389,
0.021323872730135918,
0.015276981517672539,
-0.026333820074796677,
-0.013762326911091805,
0.009064752608537674,
0.009335342794656754,
-0.007400226779282093,
0.016349878162145615,
-0.013540730811655521,
0.014340261928737164,
-0.013923644088208675,
-0.005703311879187822,
-0.02943127229809761,
0.008820398710668087,
0.005703824106603861,
0.03150324523448944,
-0.008630416356027126,
0.009592258371412754,
0.0022374822292476892,
0.026542063802480698,
-0.032479867339134216,
0.011811811476945877,
0.008825498633086681,
-0.0067941779270768166,
0.00046043097972869873,
-0.00022627878934144974,
-0.035627931356430054,
-0.011108717881143093,
-0.010858423076570034,
0.02562972903251648,
0.01176040805876255,
-0.0006379882106557488,
0.015474522486329079,
-0.02179129421710968,
0.0019268069881945848,
-0.027152076363563538,
0.016232945024967194,
0.009815065190196037,
0.014760066755115986,
-0.05128181725740433,
0.037350889295339584,
0.009384283795952797,
-0.006698780693113804,
-0.001484025502577424,
-0.08121271431446075,
-0.01930636540055275,
-0.009042857214808464,
-0.0343036875128746,
0.00324319233186543,
-0.013779005967080593,
-0.003150537610054016,
-0.008145967498421669,
-0.0026447740383446217,
-0.0035941340029239655,
-0.016569392755627632,
0.007606208324432373,
-0.014177398756146431,
-0.0010158342774957418,
-0.043954912573099136,
-0.012538379058241844,
0.013472811318933964,
0.007660237140953541,
0.009726927615702152,
-0.030224964022636414,
0.024164479225873947,
0.008447528816759586,
-0.012153515592217445,
0.013206900097429752,
-0.0018279831856489182,
-0.011435166001319885,
0.008101463317871094,
-0.005197562277317047,
-0.01371245738118887,
0.0051682922057807446,
-0.021967660635709763,
-0.002895379438996315,
0.0018935026600956917,
0.0018573743291199207,
0.014950302429497242,
0.03296598047018051,
-0.029985398054122925,
0.00004913238808512688,
-0.01422177068889141,
0.0013876345474272966,
-0.003860407043248415,
0.017126329243183136,
0.029016295447945595,
0.011508375406265259,
0.018098551779985428,
-0.0033560004085302353,
0.015194939449429512,
-0.01574688032269478,
0.01490224339067936,
-0.0016898592002689838,
-0.021555885672569275,
0.0031929397955536842,
0.003810703754425049,
0.02117680013179779,
-0.014577238820493221,
0.0035224510356783867,
-0.020259149372577667,
-0.009406935423612595,
-0.012105796486139297,
-0.006162308156490326,
-0.02010655403137207,
-0.026413410902023315,
-0.012804467231035233,
-0.009732011705636978,
0.014705883339047432,
-0.007147246040403843,
0.0182118508964777,
-0.024567630141973495,
-0.013411002233624458,
0.014476319774985313,
-0.022781720384955406,
-0.012862649746239185,
0.002703868318349123,
-0.006924368441104889,
-0.00713418610394001,
-0.01759173348546028,
-0.01297447457909584,
0.0011063218116760254,
0.03170378506183624,
0.019627349451184273,
-0.027578745037317276,
-0.00020569562911987305,
-0.020600400865077972,
-0.002376711694523692,
-0.0144692063331604,
-0.041631195694208145,
0.00681017991155386,
0.050309114158153534,
0.02346489205956459,
-0.01823718287050724,
-0.01955234259366989,
0.01905612275004387,
-0.021023577079176903,
0.010086707770824432,
0.00842364877462387,
-0.0120979780331254,
-0.005494432523846626,
0.017313111573457718,
0.02511373721063137,
0.010030556470155716,
-0.011434663087129593,
0.00035026506520807743,
0.022424088791012764,
-0.006316118407994509,
0.03818464279174805,
0.019864307716488838,
0.0061883097514510155,
0.006166248582303524,
-0.02733246609568596,
-0.0016023919451981783,
0.009787647053599358,
-0.009678401052951813,
-0.0054839737713336945,
0.03345473110675812,
0.015297161415219307,
0.013065734878182411,
-0.008211775682866573,
-0.027907446026802063,
0.07152454555034637,
-0.006216241046786308,
0.0036976123228669167,
-0.01646408997476101,
-0.00048067281022667885,
-0.021211614832282066,
-0.010083376429975033,
-0.008565777912735939,
-0.021899212151765823,
0.00783456675708294,
0.013472707942128181,
-0.0009022601880133152,
-0.004521212540566921,
0.0009650602005422115,
-0.012461941689252853,
0.022739967331290245,
-0.005183751694858074,
-0.018144864588975906,
-0.007071598898619413,
-0.0073660570196807384,
0.009895671159029007,
-0.03746812045574188,
-0.02795298583805561,
-0.011209393851459026,
-0.004862477537244558,
-0.03475956991314888,
0.019849661737680435,
-0.014160489663481712,
-0.023403383791446686,
0.006272990722209215,
0.011626023799180984,
0.0012151575647294521,
-0.007082278840243816,
0.030048266053199768,
0.027853839099407196,
-0.00903940200805664,
0.016087595373392105,
-0.01064348965883255,
0.021615896373987198,
0.01680801250040531,
-0.02168724685907364,
-0.011386483907699585,
0.01359483227133751,
0.009333722293376923,
-0.014940830878913403,
-0.01707160472869873,
0.01856865920126438,
-0.0053587439469993114,
0.0024476873222738504,
0.0027931369841098785,
-0.01648254320025444,
0.005178666673600674,
0.015649255365133286,
0.01562875136733055,
-0.01399680133908987,
-0.03633386641740799,
0.006284281611442566,
-0.009175719693303108,
0.032717928290367126,
-0.003643226809799671,
-0.012963220477104187,
0.02880537323653698,
0.033626388758420944,
-0.037119537591934204,
0.00015884707681834698,
-0.010051989927887917,
-0.027564991265535355,
-0.0001480033970437944,
0.004913239739835262,
-0.00845710001885891,
0.019068356603384018,
0.010350348427891731,
-0.015565119683742523,
-0.0035971454344689846,
-0.019469404593110085,
-0.0027672736905515194,
-0.0016269474290311337,
0.0075686960481107235,
0.01734505593776703,
-0.020525917410850525,
-0.022540908306837082,
0.0013944769743829966,
0.00028986856341362,
0.02259497530758381,
0.011755211278796196,
0.005104945506900549,
-0.021506357938051224,
-0.0740993320941925,
0.004193700850009918,
0.000059137120842933655,
-0.00968988612294197,
0.005549230147153139,
-0.021890386939048767,
-0.02933882363140583,
-0.01728150062263012,
0.03176369518041611,
0.0017820297507569194,
-0.0007297508418560028,
0.016817796975374222,
-0.001980316825211048,
-0.015861541032791138,
0.013393010944128036,
0.004676014184951782,
-0.02822986990213394,
0.00995942484587431,
-0.04566345363855362,
0.0008487359154969454,
0.013368125073611736,
-0.012388989329338074,
-0.02884245663881302,
0.017396818846464157,
-0.005632487125694752,
-0.08015870302915573,
-0.002750768791884184,
-0.0037593021988868713,
-0.0023992694914340973,
0.0010105314431712031,
0.001126972958445549,
0.014854427427053452,
-0.00508985947817564,
0.005273475311696529,
-0.01945241540670395,
-0.02099279873073101,
0.012772468850016594,
-0.016594141721725464,
-0.008906830102205276,
0.010725612752139568,
-0.010682121850550175,
0.008450934663414955,
-0.004720842000097036,
-0.014224368147552013,
-0.01633165404200554,
-0.006969940848648548,
-0.0020055798813700676,
-0.01224430650472641,
-0.010498621501028538,
-0.01098533347249031,
0.012259554117918015,
0.0046617924235761166,
0.01934690959751606,
0.004049534443765879,
-0.0035904468968510628,
0.02206365391612053,
0.00887354463338852,
-0.030086329206824303,
-0.04644553363323212,
-0.019113479182124138,
-0.019900020211935043,
-0.011879261583089828,
0.00676822941750288,
-0.03307124599814415,
-0.01950760930776596,
-0.004197775851935148,
0.01642024517059326,
-0.0356886088848114,
0.011409501545131207,
-0.02927851304411888,
0.0006225276738405228,
0.007733273319900036,
-0.009023935534060001,
0.00648691738024354,
-0.020754121243953705,
0.0031495909206569195,
0.016723355278372765,
0.013326147571206093,
0.00808623619377613,
-0.011492501944303513,
0.037010375410318375,
-0.00009726732969284058,
-0.0028730938211083412,
0.020587632432579994,
0.004902629181742668,
0.003339995862916112,
-0.015640998259186745,
-0.004745902493596077,
0.07097034156322479,
0.005219203419983387,
0.015002584084868431,
-0.03228204697370529,
0.007963493466377258,
0.0034739957191050053,
0.015542076900601387,
-0.004398213233798742,
-0.00479833222925663,
-0.021054700016975403,
0.04631798714399338,
-0.010304233990609646,
-0.015033837407827377,
0.014547580853104591,
0.01293836161494255,
0.013284445740282536,
0.05109253153204918,
0.008325244300067425,
0.009745117276906967,
0.02680918201804161,
-0.013162249699234962,
0.003152209799736738,
-0.02368398755788803,
-0.0042838165536522865,
-0.006775964982807636,
-0.014857950620353222,
0.027778148651123047,
-0.004016960971057415,
-0.009466486983001232,
0.03249271586537361,
-0.012410160154104233,
-0.003924631979316473,
0.00035430234856903553,
-0.0012131407856941223,
0.03528931736946106,
0.03910934925079346,
-0.003963544499129057,
0.01120214257389307,
-0.018604833632707596,
-0.0005669062957167625,
-0.012674989178776741,
-0.0029046160634607077,
0.009136879816651344,
0.0254148468375206,
0.0036738060880452394,
0.020512506365776062,
0.017541687935590744,
-0.021395567804574966,
0.00766490213572979,
-0.005816418211907148,
0.018093422055244446,
0.001712636323645711,
-0.0031968785915523767,
-0.035150930285453796,
0.03354382514953613,
0.00017546024173498154,
-0.024881776422262192,
0.013418321497738361,
-0.01659873127937317,
-0.03126029670238495,
-0.0076826391741633415,
-0.016742844134569168,
-0.022292453795671463,
-0.024139832705259323,
0.005253916140645742,
-0.024893924593925476,
0.034516528248786926,
-0.011160608381032944,
0.0010533938184380531,
0.018108326941728592,
0.0035557039082050323,
0.011287504807114601,
0.012996628880500793,
0.028754062950611115,
0.03530358895659447,
-0.0008927235612645745,
-0.014510352164506912,
-0.021243292838335037,
0.006878245621919632,
-0.003978299908339977,
-0.01657920703291893,
0.018109241500496864,
-0.010810625739395618,
0.007162824273109436,
-0.018219858407974243,
0.010097946971654892,
-0.019532669335603714,
-0.015952957794070244,
-0.0024694500025361776,
0.015262794680893421,
0.026082713156938553,
-0.020614253357052803,
0.00688148383051157,
0.010833222419023514,
0.014292992651462555,
0.03481582924723625,
-0.004201514180749655,
0.010458413511514664,
0.01429696287959814,
0.02156972698867321,
0.012713361531496048,
-0.01313506904989481,
-0.018630163744091988,
-0.0285742599517107,
-0.027420859783887863,
-0.008593011647462845,
-0.020755525678396225,
0.004671105649322271,
0.006323446519672871,
0.02081085555255413,
0.03576426953077316,
-0.009527869522571564,
0.025905665010213852,
0.015847526490688324,
0.003735259175300598,
0.021294377744197845,
-0.013173367828130722,
0.013392654247581959,
-0.02662086673080921,
-0.014373629353940487,
-0.03714386373758316,
-0.01046026311814785,
0.011697034351527691,
0.024095650762319565,
0.004112464375793934,
-0.04153607040643692,
-0.013213022612035275,
0.0215816181153059,
-0.0017567833419889212,
0.007261284627020359,
0.014905134215950966,
-0.025545937940478325,
0.0008158741984516382,
-0.0047668470069766045,
-0.0008931965567171574,
-0.022359706461429596,
-0.01044007483869791,
-0.008012567646801472,
0.0022665420547127724,
0.03489682823419571,
0.021176498383283615,
-0.026130545884370804,
0.0018622956704348326,
0.00909023080021143,
0.00767979770898819,
-0.008451612666249275,
0.015682462602853775,
0.017624568194150925,
0.010090772993862629,
-0.010768676176667213,
-0.0012327434960752726,
-0.004674061667174101,
-0.0014502734411507845,
-0.006841280963271856,
-0.00438791885972023,
0.013071546331048012,
-0.0035584340803325176,
0.0021228883415460587,
-0.023794857785105705,
-0.0059798057191073895,
0.01867103949189186,
0.0030443978030234575,
0.024080242961645126,
0.022964291274547577,
-0.0012267446145415306,
-0.01604989729821682,
-0.02175419218838215,
-0.0169021338224411,
0.0004123793914914131,
-0.016808506101369858,
0.012523530051112175,
-0.012722702696919441,
-0.013934724032878876,
0.024421803653240204,
-0.02360648289322853,
-0.016018182039260864,
-0.004370465409010649,
0.0012891953811049461,
0.037236228585243225,
-0.005907075479626656,
0.014439532533288002,
-0.04652051627635956,
-0.004909246228635311,
-0.006982654333114624,
0.0023994881194084883,
0.009376505389809608,
0.0017201376613229513,
-0.009523564018309116,
-0.0029212981462478638,
-0.00305322278290987,
-0.02475355565547943,
-0.014285570941865444,
-0.018686417490243912,
0.001946325646713376,
-0.029003456234931946,
0.020118609070777893,
0.005027733743190765,
0.0078117260709404945,
-0.0007951051229611039,
0.01478475984185934,
0.011896203272044659,
-0.022283824160695076
] | [
-0.19823093712329865,
0.09320277720689774,
0.3171611726284027,
0.062376003712415695,
0.12543416023254395,
0.11433137208223343,
-0.14073903858661652,
0.03514762967824936,
-0.45278388261795044,
-0.7150204181671143,
0.030493026599287987,
0.31686410307884216,
-0.19719648361206055,
-0.2837863266468048,
0.13102664053440094,
0.3522918224334717,
0.3820936381816864,
0.24305766820907593,
-0.5780375003814697,
-0.9843044877052307,
-0.05498378351330757,
-0.12557226419448853,
0.752800464630127,
0.12207728624343872,
0.3884425163269043,
-0.218505397439003,
0.22017547488212585,
0.18588244915008545,
0.44165802001953125,
-0.6283684968948364,
-0.11389907449483871,
-0.05389999598264694,
0.060839515179395676,
-0.14715281128883362,
-0.49491411447525024,
-0.239501491189003,
-0.6166898012161255,
-0.46639126539230347,
0.36663201451301575,
-0.09453147649765015,
-0.07907295227050781,
-0.05420052632689476,
0.039665304124355316,
0.5532649755477905,
0.006098341662436724,
-0.18789711594581604,
-1.106793761253357,
0.5779531002044678,
0.03675476089119911,
-0.10748513787984848,
-0.3899579644203186,
0.6911519169807434,
0.19369077682495117,
0.2597144544124603,
0.3596506118774414,
0.19139693677425385,
-0.7820271849632263,
-0.13912144303321838,
0.34429654479026794,
-0.668195903301239,
-0.1751139611005783,
-0.04012487456202507,
-0.27231189608573914,
0.5199052691459656,
0.033252913504838943,
0.17779867351055145,
0.3533461093902588,
-0.21763072907924652,
-0.40639880299568176,
-0.30439913272857666,
0.011878547258675098,
-0.22269463539123535,
0.09670599550008774,
0.125631183385849,
-0.1709536910057068,
-0.3348739445209503,
-0.40834659337997437,
-0.27896440029144287,
0.17070816457271576,
-0.1285616159439087,
-0.110636405646801,
0.4934845268726349,
0.2140895128250122,
0.30472850799560547,
0.1586262732744217,
0.12347225844860077,
-0.4635586142539978,
0.5828560590744019,
-0.3000532388687134,
-0.012310195714235306,
-0.5579726696014404,
-0.007000013720244169,
0.3422146737575531,
0.3782391846179962,
0.21017366647720337,
0.5872994661331177,
-0.12214434891939163,
-0.1435377597808838,
0.14321164786815643,
0.1110595166683197,
0.03680238127708435,
-0.24332281947135925,
0.14875063300132751,
-0.5892007350921631,
-0.2227226197719574,
-0.28414177894592285,
-0.16729234158992767,
-0.32246747612953186,
-0.3589687645435333,
-0.05938183516263962,
-0.6168034076690674,
-0.42781588435173035,
-0.737105667591095,
-0.5107417106628418,
0.6900448799133301,
-0.1340506374835968,
0.07681654393672943,
-0.665187656879425,
0.06612323224544525,
-0.1209881454706192,
-0.4305028021335602,
1.3360100984573364,
-0.26050108671188354,
0.4358671307563782,
-0.0970158502459526,
-0.32645368576049805,
0.3516966998577118,
-0.34417423605918884,
0.05819644778966904,
0.2978542745113373,
0.3035614788532257,
0.9163225889205933,
-0.02580016665160656,
-0.1816195696592331,
-0.13150744140148163,
0.035971999168395996,
0.08316832035779953,
0.47664061188697815,
0.07947241514921188,
0.05013120919466019,
-0.6038241386413574,
-0.6229169368743896,
0.18042288720607758,
-0.27622556686401367,
0.2102072834968567,
-0.0428524948656559,
0.053185828030109406,
-0.20739436149597168,
0.5200226306915283,
-0.2830386459827423,
0.4108656942844391,
-0.23128673434257507,
-0.8297240138053894,
-0.3495374619960785,
-0.05204455554485321,
0.5604246854782104,
0.4080214202404022,
-0.31856757402420044,
0.0008366359397768974,
0.2185315638780594,
0.1883404701948166,
-0.38800951838493347,
-0.10742588341236115,
-0.3051636219024658,
-0.006451187189668417,
0.26844581961631775,
0.5910035967826843,
0.42800337076187134,
0.3525122106075287,
-0.7532946467399597,
-0.28681275248527527,
-0.6391288638114929,
-0.06021276116371155,
-0.5037521123886108,
-0.4280191659927368,
-0.1788834184408188,
0.2622184753417969,
0.21378129720687866,
0.12219293415546417,
0.057134803384542465,
-0.7114551067352295,
0.5843594670295715,
-0.24840441346168518,
-0.26355499029159546,
0.4288684129714966,
-0.29628095030784607,
0.6397544145584106,
-0.07832817733287811,
-0.5026143789291382,
-0.04847516119480133,
0.3743959367275238,
-0.07029938697814941,
0.7245990633964539,
-0.8103410601615906,
1.6671221256256104,
-0.2610650062561035,
-0.399831086397171,
0.8946558237075806,
0.2158537060022354,
-0.16865843534469604,
-0.34084710478782654,
0.19301360845565796,
0.6350471377372742,
-0.8097665309906006,
-0.22833575308322906,
0.06366067379713058,
0.4110310673713684,
0.0175193902105093,
-0.1662278175354004,
-0.015339895151555538,
-0.12132665514945984,
-0.1699948012828827,
-0.1321820616722107,
-0.16100925207138062,
0.6933824419975281,
-0.45699542760849,
0.27435722947120667,
-0.026464832946658134,
-0.6423804759979248,
0.2762366831302643,
0.5445657968521118,
-0.5622616410255432,
0.37923625111579895,
1.0252633094787598,
-0.3749159574508667,
0.7334132194519043,
0.8561615347862244,
0.6476160287857056,
0.46522432565689087,
0.15222328901290894,
0.19760705530643463,
-0.2606191039085388,
-0.05646704137325287,
-0.021338846534490585,
-0.24006867408752441,
-0.1371568739414215,
0.19737553596496582,
-0.12383299320936203,
-0.27871349453926086,
0.08994390070438385,
-0.3631260395050049,
0.9878242611885071,
-0.7562639713287354,
-0.13228365778923035,
-0.05845864489674568,
-0.5840525031089783,
-0.38478603959083557,
0.05617576092481613,
-1.0185542106628418,
0.016242194920778275,
-0.05265366658568382,
0.4460678994655609,
0.23118296265602112,
-0.28817662596702576,
0.287861168384552,
-0.17117474973201752,
0.19433951377868652,
-0.019848113879561424,
0.3170390725135803,
-0.3890891671180725,
0.5251544117927551,
-0.30324462056159973,
0.17828135192394257,
0.2498459368944168,
-0.044732656329870224,
-0.28767868876457214,
-0.2770176827907562,
-0.28499987721443176,
1.1849315166473389,
0.5763718485832214,
0.7264005541801453,
-0.13135063648223877,
-0.3108120560646057,
0.004554104059934616,
0.1589272916316986,
0.08629553020000458,
-0.0662263035774231,
0.4229643642902374,
-0.09112874418497086,
-0.11804044991731644,
-0.26683053374290466,
0.14034093916416168,
0.4874888062477112,
0.10305992513895035,
-0.19351543486118317,
0.12298781424760818,
-0.2985434830188751,
-0.2625201642513275,
-0.20140573382377625,
-0.495758593082428,
0.06459049135446548,
-0.059026848524808884,
-0.03404710069298744,
-0.21379953622817993,
0.5272128582000732,
0.3801547586917877,
-0.07620031386613846,
0.5929511785507202,
0.3920553922653198,
-0.1195724606513977,
-0.2067779302597046,
0.005391810089349747,
-0.311916321516037,
0.009322896599769592,
-0.08524901419878006,
0.13036151230335236,
-0.3326900899410248,
0.1571810096502304,
-5.750597953796387,
0.39167362451553345,
0.0427064374089241,
-0.20227348804473877,
-0.00770201301202178,
-0.1616063416004181,
0.3633723855018616,
-0.11567854136228561,
0.6427774429321289,
0.10960865020751953,
-0.031073996797204018,
0.2288951724767685,
-0.2031610608100891,
-0.07208644598722458,
-0.86042720079422,
-0.2220243513584137,
-0.3288154900074005,
-0.24893894791603088,
0.5224063396453857,
0.06483122706413269,
0.4444597661495209,
-0.6382476687431335,
-0.1309008151292801,
0.17436711490154266,
-0.24947501718997955,
-0.17235355079174042,
-0.5977950096130371,
0.022852463647723198,
-0.0028073505964130163,
-0.13520686328411102,
0.01998100057244301,
-0.5131093263626099,
0.12684191763401031,
-0.2589242160320282,
0.6826907396316528,
-0.027748269960284233,
0.22307467460632324,
0.16277901828289032,
0.3789435029029846,
-0.4614124298095703,
0.5622564554214478,
0.3472161591053009,
-0.1792292296886444,
-0.12556570768356323,
0.550887942314148,
-0.2207781970500946,
-0.11575533449649811,
0.16587921977043152,
-0.16879905760288239,
0.70008385181427,
-0.17614412307739258,
-0.42646923661231995,
0.2969905734062195,
0.23709753155708313,
0.6821796894073486,
0.14520737528800964,
-0.18787004053592682,
-0.6678792238235474,
-0.12021861225366592,
0.4512924551963806,
-0.18254610896110535,
-0.34612324833869934,
-0.3627026081085205,
-0.8293849229812622,
-0.15604116022586823,
0.8015958666801453,
-0.7049364447593689,
-0.4476066529750824,
0.20562061667442322,
-0.3666296899318695,
-0.09058767557144165,
0.3105807602405548,
0.37680375576019287,
-0.5232642889022827,
0.6737205982208252,
-0.34299635887145996,
0.0029669024515897036,
0.5786939859390259,
-0.2266777604818344,
-0.06458871811628342,
-0.43647196888923645,
-0.3363820016384125,
-0.1041346937417984,
-0.44059160351753235,
0.14599986374378204,
-0.1515066921710968,
-0.178793266415596,
-0.20113210380077362,
-0.2840903401374817,
0.5115436911582947,
0.17271998524665833,
-0.7969147562980652,
-0.015641840174794197,
0.7365684509277344,
-0.2498714029788971,
-0.009142081253230572,
-0.029508357867598534,
0.44741493463516235,
0.6778066754341125,
0.32681748270988464,
0.6610421538352966,
0.1353524625301361,
-0.40776532888412476,
-0.4481963515281677,
-0.25667449831962585,
0.2883637249469757,
-0.1828376054763794,
0.35702335834503174,
0.6957534551620483,
-0.45968005061149597,
-0.1997309774160385,
-0.38903239369392395,
-0.6618561148643494,
-0.5303502678871155,
0.24053843319416046,
-0.3960973620414734,
-0.4939069449901581,
0.0502663217484951,
0.9452796578407288,
-0.24521282315254211,
0.030631080269813538,
0.3578571677207947,
-0.7105548977851868,
0.16318197548389435,
0.25439533591270447,
0.05776307359337807,
0.2154039889574051,
0.9549251198768616,
-0.6046398878097534,
-0.49582669138908386,
0.05004984885454178,
0.19475647807121277,
0.03825702890753746,
0.4407721161842346,
0.13113141059875488,
-0.5074464678764343,
-0.18863682448863983,
0.7067693471908569,
0.14846283197402954,
-0.43910518288612366,
0.2554895281791687,
-0.17908887565135956,
-0.325376957654953,
-0.5235114097595215,
0.2764171361923218,
0.39321810007095337,
-0.6942322254180908,
0.5194316506385803,
-0.9363179206848145,
-0.3250950574874878,
0.11994969844818115,
-0.5461738109588623,
-0.015101009979844093,
0.49960169196128845,
0.026266103610396385,
-0.09048181772232056,
0.0963459387421608,
0.18923752009868622,
0.45418763160705566,
-0.4034082591533661,
0.5855122208595276,
0.12889976799488068,
-0.678593635559082,
0.1861298382282257,
-0.407814085483551,
0.15598833560943604,
0.14563468098640442,
-0.7530869841575623,
-0.1838167905807495,
0.3515743911266327,
-0.5079375505447388,
-0.1340615600347519,
0.025900419801473618,
-0.4158921241760254,
-0.13926680386066437,
-0.5381397008895874,
-0.24071945250034332,
0.02913379669189453,
0.17663925886154175,
0.019066089764237404,
0.006998563650995493,
-0.6325977444648743,
0.3840312361717224,
0.2035396695137024,
0.1401485651731491,
-0.3454633951187134,
0.40854543447494507,
0.2398911565542221,
0.09269832819700241,
-0.6620223522186279,
0.33007335662841797,
0.03412191569805145,
-0.11078645288944244,
-0.2585224211215973,
0.4279502034187317,
0.4762592315673828,
0.5110858082771301,
0.3502195477485657,
-0.13255006074905396,
-0.4070027470588684,
-0.037437040358781815,
0.3252931833267212,
0.189200758934021,
0.5604951977729797,
0.6518972516059875,
0.4141803979873657,
-0.467695415019989,
0.4193296432495117,
-0.04160289093852043,
-0.3229557275772095,
-0.36748963594436646,
-0.4537481665611267,
0.5974341630935669,
0.42454445362091064,
0.21789534389972687,
0.05515154451131821,
0.19712026417255402,
-0.14075307548046112,
-0.3832371234893799,
0.47018563747406006,
0.17432834208011627,
0.2268541008234024,
-0.29078903794288635,
-0.22742238640785217,
-0.1774076223373413,
0.2846726179122925,
0.4493008553981781,
-0.6589857339859009,
0.49404868483543396,
0.1585630476474762,
-0.2412554770708084,
-0.649738609790802,
0.09095848351716995,
0.45368295907974243,
0.02507035993039608,
-0.5571725964546204,
-0.3077014982700348,
0.19348901510238647,
-0.36478278040885925,
0.3182668685913086,
0.3635927438735962,
0.6512879729270935,
-0.2964254915714264,
0.19966921210289001,
0.014298081398010254,
0.9893096089363098,
0.07228435575962067,
-0.5852940082550049,
0.07912615686655045,
-0.3367350995540619,
0.5347891449928284,
-0.24609579145908356,
0.13500916957855225,
0.5958179831504822,
0.564662516117096,
-0.1842464804649353,
-0.1513528674840927,
-0.3328712284564972,
-0.12831351161003113,
0.23975010216236115,
-0.29790428280830383,
0.06702565401792526,
-0.3141593933105469,
0.18397420644760132,
0.11335758119821548,
0.2988152503967285,
0.06885036826133728,
-0.4798753559589386,
0.37470102310180664,
0.3354281783103943,
0.22284801304340363,
-0.5945353507995605,
0.260285347700119,
-0.1478608250617981,
-0.5845505595207214,
0.008510217070579529,
-0.3169851303100586,
0.26937687397003174,
0.46810030937194824,
0.18126961588859558,
-0.1871686577796936,
-0.46732088923454285,
0.25408652424812317,
-0.7554789781570435,
0.40255725383758545,
-0.4779111444950104,
0.17470520734786987,
-0.4041807949542999,
0.40668967366218567,
0.3450247645378113,
-0.4421923756599426,
-0.0835985615849495,
-0.3859159052371979,
-0.37090277671813965,
-0.19884546101093292,
0.1775921881198883,
-0.005362295545637608,
0.5347773432731628,
-0.01513768918812275,
0.18964940309524536,
-0.6825358867645264,
0.6291502118110657,
0.34294167160987854,
-0.4501110315322876,
-0.24378518760204315,
0.20449410378932953,
-0.18820159137248993,
-0.2908216118812561,
-0.5440255403518677,
0.1556495726108551,
-0.3725341856479645,
-0.2828633189201355,
0.44183647632598877,
-0.11158906668424606,
-0.365812748670578,
0.3310026526451111,
0.02960372529923916,
-0.12093928456306458,
0.09157954901456833,
0.43725401163101196,
0.07681640237569809,
1.0362586975097656,
0.2873980700969696,
-0.30378618836402893,
-0.0483221560716629,
0.5563310980796814,
0.4819755554199219,
0.004504377953708172,
-0.009628621861338615,
0.9680705666542053,
0.6109659075737,
-0.11871304363012314,
-0.08602405339479446,
0.7986942529678345,
0.6527713537216187,
-0.04909101128578186,
0.2955535650253296,
-0.5945234894752502,
-0.1091715469956398,
0.08359403908252716,
0.6371992826461792,
0.7967350482940674,
-0.7826433777809143,
-0.048921044915914536,
0.4262182414531708,
-0.14701473712921143,
0.3402855098247528,
-0.1407274603843689,
-0.23568212985992432,
0.43387243151664734,
0.4971717894077301,
-0.647060751914978,
-0.3168496787548065,
0.1802530735731125,
-0.6183276772499084,
0.10538631677627563,
0.40475067496299744,
0.3027236759662628,
-0.6699202656745911,
0.2097151279449463,
-0.2728816568851471,
0.45043519139289856,
0.35360032320022583,
-0.11316587775945663,
0.04984578117728233,
-0.4389001727104187,
0.5962637662887573,
0.11491242796182632,
0.41088417172431946,
-0.15709243714809418,
-0.5950440764427185,
0.45446816086769104,
-0.2613900601863861,
-0.4341734051704407,
0.15420903265476227,
-0.17709946632385254,
-0.3350887596607208,
-0.11239778995513916,
-0.04443925991654396,
0.5777780413627625,
-0.019313881173729897,
-0.04280419647693634,
-0.1792316436767578,
-0.8704708218574524,
-0.5033652186393738,
-0.37166866660118103,
0.026301568374037743,
-0.15346136689186096,
-0.14122331142425537,
-0.019333617761731148,
0.30716076493263245,
-0.44213104248046875,
0.5030813217163086,
0.15491101145744324,
0.016343215480446815,
-0.32432880997657776,
-0.5533835887908936,
0.44781386852264404,
0.41572967171669006,
0.8692115545272827,
0.07717107236385345,
0.2666192352771759,
-0.31086140871047974,
0.38509970903396606,
-0.3417685031890869,
0.4058246910572052,
-0.40637996792793274,
-0.47777214646339417,
-0.4490380585193634,
-0.4374113082885742,
1.4920881986618042,
0.7763939499855042,
-0.4337567389011383,
0.15399864315986633,
0.5389263033866882,
1.0076831579208374,
0.32182756066322327,
-0.555681586265564,
-0.2003728449344635,
-0.425104558467865,
-0.0994073823094368,
-0.21907740831375122,
0.661721408367157,
0.46277064085006714,
-0.1648225486278534,
0.11079245805740356,
0.6898441314697266,
-0.310684472322464,
-0.41016435623168945,
0.0641864761710167,
-0.07107855379581451,
0.1319151520729065,
-0.6797424554824829,
0.08921852707862854,
-0.2872426211833954,
0.1786695420742035,
-0.35300546884536743,
-0.2845800817012787,
0.3944278359413147,
-0.16693894565105438,
0.2873670160770416,
0.015968117862939835,
0.1252296268939972,
-0.1627773493528366,
-0.1070471927523613,
-0.5786941647529602,
-0.0790550708770752,
-0.7703732848167419,
-0.52962327003479,
0.10071298480033875,
0.19859375059604645,
-0.5266005992889404,
0.3697755038738251,
0.06543856114149094,
0.3671029508113861,
-0.09816846996545792,
0.07155726104974747,
-0.6330448389053345,
-0.2327585518360138,
-0.5785579085350037
] |
The term beta diversity has been used to refer to a wide variety of phenomena. Although all of these encompass some kind of compositional heterogeneity between places, many are not related to each other in any predictable way. The present two-part review aims to put the different phenomena that have been called beta diversity into a common conceptual framework, and to explain what each of them measures. In this first part, the focus is on defining a beta component of diversity. This involves deciding what diversity is and how the observed total or gamma diversity (g) is partitioned into alpha (a) and beta (b) components. Several different definitions of ‘‘beta diversity’’ that result from these decisions have been used in the ecological literature. True beta diversity is obtained when the total effective number of species in a dataset (true gamma diversity g) is multiplicatively partitioned into the effective number of species per compositionally distinct | [
-0.025646183639764786,
0.017704542726278305,
0.00421880092471838,
0.006320086773484945,
0.05293432995676994,
-0.033678438514471054,
0.008008770644664764,
-0.017159346491098404,
-0.01449144072830677,
-0.003354984801262617,
-0.009853052906692028,
0.020483791828155518,
-0.0022657462395727634,
0.014163155108690262,
-0.03565046191215515,
-0.029509106650948524,
0.00826895423233509,
-0.017906203866004944,
-0.0024745622649788857,
-0.01681561768054962,
-0.021076692268252373,
-0.00322952913120389,
0.010211280547082424,
0.005375047214329243,
0.008840380236506462,
0.0014685362111777067,
0.0043210219591856,
0.002568461699411273,
-0.010936600156128407,
0.0076520806178450584,
0.0056678298860788345,
-0.004905222915112972,
0.0042940727435052395,
-0.015231187455356121,
0.00743176368996501,
0.007479580584913492,
0.0016511196736246347,
0.013824863359332085,
-0.01538760308176279,
-0.0020339502952992916,
0.013412157073616982,
-0.008658370934426785,
-0.0016393642872571945,
-0.01083544921129942,
-0.0073171621188521385,
0.00716581754386425,
0.0013528933050110936,
-0.011410757899284363,
-0.004212233237922192,
0.002350691705942154,
-0.013531649485230446,
-0.0008487076265737414,
0.0026026612613350153,
-0.0016638912493363023,
-0.0054146344773471355,
-0.01305914856493473,
0.018059367313981056,
-0.021059028804302216,
0.012308286502957344,
0.013832299038767815,
-0.0023960573598742485,
-0.00848228856921196,
0.00971152726560831,
-0.037694670259952545,
-0.019554220139980316,
-0.06784240901470184,
0.0006825174205005169,
0.008536837995052338,
-0.001775491749867797,
-0.03237898647785187,
-0.0037138736806809902,
0.010955546982586384,
-0.0016049970872700214,
0.0033699169289320707,
0.0327141173183918,
0.013951399363577366,
-0.011276114732027054,
0.030213654041290283,
-0.004207014571875334,
-0.0033384128473699093,
-0.01135863084346056,
0.01254703663289547,
0.017351187765598297,
0.020258881151676178,
0.01836482621729374,
-0.0005714634899049997,
-0.013570616021752357,
0.016601216048002243,
-0.0038441147189587355,
-0.006768397055566311,
0.014294147491455078,
-0.01721220649778843,
0.015484478324651718,
-0.015836048871278763,
-0.010110918432474136,
0.012684963643550873,
-0.02595243789255619,
-0.007395136170089245,
-0.017002660781145096,
-0.0018253694288432598,
-0.02648296393454075,
0.016660692170262337,
0.02400699257850647,
-0.009012862108647823,
0.0063849263824522495,
0.009982233867049217,
-0.002181359101086855,
0.028021926060318947,
-0.026738274842500687,
-0.0006626878748647869,
-0.002058017998933792,
-0.012187987565994263,
0.007748239673674107,
-0.0048603881150484085,
-0.008839065209031105,
-0.035908546298742294,
-0.009632019326090813,
0.010047518648207188,
-0.003281747456640005,
-0.0010078882332891226,
0.016849301755428314,
0.011778650805354118,
0.002969000954180956,
-0.016903676092624664,
0.0013113535242155194,
0.008823717013001442,
0.025546226650476456,
0.002024382119998336,
0.0031294540967792273,
0.005974519066512585,
-0.007482674904167652,
0.009445901028811932,
0.010982840321958065,
-0.000347101129591465,
-0.002700718119740486,
-0.007990061305463314,
-0.03352196142077446,
-0.024884290993213654,
-0.013436718843877316,
-0.011420052498579025,
-0.003426595125347376,
0.009399810805916786,
0.003490680828690529,
0.000010571617167443037,
0.016732100397348404,
-0.0008818323258310556,
-0.014592424035072327,
0.020709330216050148,
0.009607826359570026,
-0.014431225135922432,
0.018776055425405502,
-0.01538711879402399,
-0.01715211197733879,
-0.0032174009829759598,
0.0021956809796392918,
0.00714606000110507,
-0.0015732294414192438,
0.011844512075185776,
0.0006146703381091356,
-0.011755939573049545,
0.012734250165522099,
-0.002512899227440357,
0.0029888676945120096,
0.006181743927299976,
0.006541362032294273,
0.017551572993397713,
0.008963936939835548,
-0.00029254809487611055,
0.00008875635103322566,
-0.002251358237117529,
-0.013711168430745602,
0.011403008364140987,
0.022246677428483963,
0.008800340816378593,
-0.002718239091336727,
0.00718736182898283,
0.026377283036708832,
0.0032884220127016306,
-0.010134726762771606,
0.06754869222640991,
-0.024045497179031372,
-0.0016991100274026394,
-0.018286850303411484,
-0.0018741604872047901,
0.011076618917286396,
0.00017480936367064714,
0.020506437867879868,
-0.01324507873505354,
0.007998413406312466,
-0.007607168983668089,
-0.01161583885550499,
0.011100887320935726,
0.024940207600593567,
0.0036877309903502464,
0.01669863983988762,
0.0030522351153194904,
0.008616321720182896,
0.004827650263905525,
0.011197860352694988,
0.007855303585529327,
0.018465641885995865,
-0.003193538635969162,
0.008369562216103077,
-0.01040328573435545,
-0.018916737288236618,
0.006140761077404022,
-0.010608595795929432,
0.0026895031332969666,
0.000552585581317544,
-0.0035116630606353283,
0.01791355200111866,
-0.007575482130050659,
-0.028361819684505463,
0.0017680288292467594,
0.022430991753935814,
-0.001389141078107059,
-0.008904370479285717,
-0.020754599943757057,
0.018075192347168922,
-0.01628415659070015,
-0.005364053882658482,
0.0010737215634435415,
0.005163181573152542,
-0.021167684346437454,
0.014696398749947548,
0.003754925448447466,
0.0027704613748937845,
0.011175915598869324,
0.006740065291523933,
-0.008887830190360546,
-0.0009666098048910499,
0.023559577763080597,
-0.00476665236055851,
0.002368620131164789,
-0.0018271553562954068,
0.01918022334575653,
0.006897859275341034,
-0.0069587258622050285,
0.0065754009410738945,
-0.0007224860601127148,
-0.007554429117590189,
-0.010186422616243362,
0.009308947250247002,
0.0022999029606580734,
-0.006861106492578983,
0.030194353312253952,
0.006891227792948484,
-0.007350855506956577,
-0.02668074518442154,
0.0022045907098799944,
-0.002404456492513418,
0.006962867453694344,
0.005778411403298378,
0.008178490214049816,
-0.01136049535125494,
0.006331239361315966,
-0.003062136471271515,
0.008215367794036865,
0.02188330888748169,
0.009866173379123211,
0.004960876889526844,
0.004578693304210901,
-0.01943017914891243,
-0.0008878135122358799,
-0.011011915281414986,
0.028263315558433533,
0.0018141628243029118,
0.014102956280112267,
0.00781939085572958,
-0.0211874358355999,
-0.0017245362978428602,
-0.010953918099403381,
0.009025830775499344,
-0.08190430700778961,
-0.011221454478800297,
0.0016527835978195071,
-0.026667520403862,
0.014619579538702965,
-0.02131909504532814,
0.006556493230164051,
0.0014006304554641247,
-0.02078673616051674,
-0.0151035375893116,
0.02564731054008007,
-0.004004881717264652,
-0.013951425440609455,
-0.006372036878019571,
0.016435040161013603,
-0.004184418357908726,
0.005463857203722,
-0.00862930715084076,
-0.006771396845579147,
0.005913094617426395,
0.0192650705575943,
0.010783933103084564,
0.014796718955039978,
-0.006524972151964903,
-0.017976298928260803,
0.04390961304306984,
0.00645448500290513,
0.0026698457077145576,
-0.028707748278975487,
0.007864519022405148,
0.00746560376137495,
-0.0291044432669878,
-0.010574666783213615,
-0.001154611585661769,
-0.00018233759328722954,
-0.02778506837785244,
-0.026206862181425095,
-0.006701206788420677,
-0.0019707009196281433,
0.0020464914850890636,
0.0051814657635986805,
0.011262733489274979,
-0.0022499333135783672,
-0.0052083940245211124,
-0.0013217285741120577,
0.004933722782880068,
-0.014179304242134094,
-0.016697080805897713,
0.01143396645784378,
-0.009647892788052559,
0.022771919146180153,
0.0006573110586032271,
0.03157275170087814,
0.003234680974856019,
-0.004286869894713163,
0.010699944570660591,
0.015391096472740173,
-0.008372321724891663,
-0.009096797555685043,
0.006333442404866219,
-0.0020677787251770496,
0.027051635086536407,
-0.006686560809612274,
-0.001979962456971407,
0.008432497270405293,
0.01063171774148941,
0.010407833382487297,
0.009066957980394363,
0.012759670615196228,
0.011639010161161423,
0.006769776344299316,
-0.010082424618303776,
-0.004281052853912115,
0.0032197609543800354,
0.016493814066052437,
-0.010141568258404732,
-0.008023695088922977,
-0.004334322642534971,
-0.012480145320296288,
-0.004330456256866455,
0.009624741971492767,
-0.0006425243336707354,
0.01682189293205738,
-0.02015909180045128,
-0.022187676280736923,
0.01593600958585739,
0.003742386121302843,
0.023128077387809753,
0.004340542480349541,
-0.017716944217681885,
-0.030291801318526268,
0.016359377652406693,
-0.004679393023252487,
0.010902110487222672,
0.0009481715969741344,
-0.01674218848347664,
0.013186484575271606,
0.004564724862575531,
0.010351565666496754,
0.008436817675828934,
0.012791438959538937,
0.007448407355695963,
-0.01818665862083435,
-0.019001251086592674,
-0.01591413840651512,
0.010827986523509026,
0.0004923092201352119,
-0.03925221413373947,
0.0007808289956301451,
-0.00982098188251257,
0.009022965095937252,
0.007639898918569088,
-0.008969241753220558,
0.018877051770687103,
0.016995761543512344,
0.02152513526380062,
-0.013328899629414082,
0.013933887705206871,
0.07315221428871155,
0.007950088009238243,
0.0002869550371542573,
-0.011708206497132778,
0.017074231058359146,
-0.014616504311561584,
0.006270893849432468,
-0.010514099150896072,
0.023262962698936462,
0.004259501118212938,
0.010189651511609554,
0.027375513687729836,
-0.007536783814430237,
0.0033571417443454266,
0.012213321402668953,
0.017682675272226334,
0.0023353551514446735,
0.0035630795173346996,
0.008523420430719852,
0.0069612059742212296,
-0.008674245327711105,
0.015547654591500759,
-0.009868178516626358,
0.020413562655448914,
-0.005808727350085974,
-0.012552260421216488,
0.003867663210257888,
-0.01733933575451374,
0.0097452811896801,
-0.002830425277352333,
0.021375827491283417,
-0.012934155762195587,
-0.0033958954736590385,
-0.004684296436607838,
0.008578125387430191,
0.0107059795409441,
-0.007200554478913546,
-0.006580515298992395,
0.007344314828515053,
0.0009313254267908633,
0.02245064452290535,
-0.007819426245987415,
-0.010794300585985184,
0.020303213968873024,
-0.010453129187226295,
0.02160143107175827,
-0.01249613706022501,
-0.004947136156260967,
-0.004002496134489775,
0.013247179798781872,
-0.008393870666623116,
0.014365284703671932,
0.005470906384289265,
0.02775910124182701,
0.025272823870182037,
0.014192836359143257,
0.006872221827507019,
-0.005091928411275148,
-0.008228477090597153,
-0.006943205371499062,
-0.025285836309194565,
-0.022786274552345276,
-0.002901383675634861,
0.002104962943121791,
-0.016200706362724304,
0.011794911697506905,
0.0031870875973254442,
-0.008046817034482956,
-0.0009807241149246693,
0.004725418984889984,
0.0174175463616848,
-0.023108435794711113,
-0.014193777926266193,
-0.020915046334266663,
0.008174329064786434,
-0.01590125821530819,
0.02735425904393196,
0.002114723203703761,
0.0012041059089824557,
-0.0089647825807333,
0.001576730515807867,
0.017061935737729073,
0.011501173488795757,
0.009570876136422157,
-0.006661919876933098,
-0.024819176644086838,
0.010384396649897099,
-0.0748850554227829,
-0.0006236272747628391,
-0.000008909031748771667,
-0.0032759292516857386,
-0.020249776542186737,
0.03212260827422142,
0.00623705331236124,
0.008735280483961105,
-0.007385133765637875,
-0.009758643805980682,
0.015695728361606598,
0.004344940651208162,
0.01610569655895233,
0.0038740974850952625,
0.00791150238364935,
0.022007036954164505,
-0.0040603745728731155,
-0.0023475755006074905,
0.003560424782335758,
0.004565285053104162,
0.007679932285100222,
0.01749785989522934,
-0.01186289545148611,
0.012554045766592026,
0.0021900213323533535,
-0.08202072978019714,
0.006076551042497158,
-0.004281242378056049,
0.023452363908290863,
-0.0060033043846488,
-0.0012124483473598957,
0.0013743515592068434,
-0.0013105240650475025,
0.005201407708227634,
-0.014736587181687355,
-0.012475388124585152,
-0.016131382435560226,
-0.02556491643190384,
0.004159634001553059,
0.013551410287618637,
-0.0033966919872909784,
0.015298428945243359,
0.020860612392425537,
-0.010450026951730251,
-0.010064225643873215,
0.032967910170555115,
0.016703983768820763,
-0.011255322024226189,
0.005602231714874506,
-0.015677982941269875,
0.018732581287622452,
-0.009914868511259556,
0.011491652578115463,
0.018065180629491806,
0.0034127184189856052,
0.01078706979751587,
-0.006985827349126339,
-0.00389489927329123,
0.019922122359275818,
-0.011178580112755299,
-0.013459193520247936,
-0.00919795036315918,
-0.006432023830711842,
0.019041333347558975,
0.0003729836316779256,
-0.0037084603682160378,
-0.004270743113011122,
0.0023031269665807486,
0.009360803291201591,
0.0021550431847572327,
0.01634332537651062,
-0.0016609251033514738,
-0.0009841043502092361,
0.006875962484627962,
0.018055735155940056,
0.011064616963267326,
-0.029479699209332466,
0.023253170773386955,
-0.008698441088199615,
-0.012985695153474808,
-0.012969383038580418,
0.0018143486231565475,
0.006394514814019203,
0.006231481675058603,
0.013473286293447018,
-0.011952091939747334,
0.0036478962283581495,
0.01033606193959713,
0.07257290184497833,
-0.011759357526898384,
0.009114563465118408,
-0.0027256691828370094,
0.006166314706206322,
-0.009621677920222282,
-0.008687800727784634,
0.0017424505203962326,
0.011104963719844818,
-0.008018434047698975,
0.014072916470468044,
-0.007555525749921799,
-0.017866017296910286,
0.0028362111188471317,
0.0007966128177940845,
0.0020719394087791443,
-0.019218772649765015,
0.008203541859984398,
0.019155390560626984,
-0.009022053331136703,
0.008029683493077755,
-0.014843698590993881,
-0.012471255846321583,
0.01980450749397278,
0.0035611973144114017,
-0.010996704921126366,
0.00640872260555625,
0.020333658903837204,
-0.003934937063604593,
-0.002999031450599432,
-0.013808067888021469,
0.004574369639158249,
-0.0024682485964149237,
-0.01245601661503315,
0.011188017204403877,
-0.005629541352391243,
0.0023719994351267815,
-0.003964859992265701,
0.009335296228528023,
0.014582156203687191,
-0.014644548296928406,
0.015713853761553764,
0.0017477523069828749,
-0.01409116666764021,
0.003567314241081476,
0.012619673274457455,
-0.003841723781079054,
-0.004475020337849855,
-0.010873835533857346,
0.01487103570252657,
0.008968658745288849,
-0.006946290377527475,
0.02145073190331459,
0.0032717862632125616,
0.014059877023100853,
0.013646924868226051,
-0.008127743378281593,
0.007091632578521967,
-0.00048734783194959164,
0.0003693625330924988,
-0.006107442080974579,
-0.013237112201750278,
-0.004162432160228491,
-0.0019965223036706448,
-0.005731276702135801,
0.0062654647044837475,
-0.000728455139324069,
-0.01368221640586853,
0.019456617534160614,
0.01258037332445383,
0.017864271998405457,
0.008939928375184536,
-0.0016906865639612079,
-0.01864267885684967,
-0.005879280157387257,
-0.003899924922734499,
-0.03583429381251335,
0.013216833584010601,
0.00023794686421751976,
-0.010648633353412151,
-0.0056856535375118256,
-0.0005374755710363388,
0.01979690231382847,
-0.020201293751597404,
-0.0024567977525293827,
-0.03840363770723343,
-0.01043657399713993,
-0.009685306809842587,
-0.003899902570992708,
0.006442030891776085,
0.03335873410105705,
0.0010608695447444916,
0.0003204060485586524,
-0.013435752131044865,
0.00472836522385478,
0.03314434736967087,
0.006746307481080294,
0.013442820869386196,
-0.014260198920965195,
-0.013496506959199905,
0.015805214643478394,
0.014024842530488968,
0.006654025055468082,
-0.008454076945781708,
-0.009639019146561623,
-0.002939447294920683,
0.030734235420823097,
-0.013825036585330963,
-0.007952729240059853,
0.025588370859622955,
-0.00029922788962721825,
0.004153755027800798,
-0.015937890857458115,
-0.009251071140170097,
-0.00504576601088047,
0.004730201326310635,
0.0020076511427760124,
0.001239034696482122,
-0.013691335916519165,
-0.005468067713081837,
0.00006002373993396759,
0.003233183640986681,
-0.009845949709415436,
-0.016357865184545517,
0.016723696142435074,
0.005717176478356123,
-0.009194470942020416,
0.012671785429120064,
-0.0048341089859604836,
-0.004862180445343256,
0.017708919942378998,
-0.027188794687390327,
0.008304314687848091,
-0.005238416604697704,
0.001551775261759758,
-0.01366478856652975,
-0.00879744067788124,
-0.01510404422879219,
-0.001147318514995277,
0.006228378973901272,
0.022363819181919098,
-0.0024529644288122654,
0.002691867994144559,
0.010798376984894276,
0.008780687116086483,
-0.011997230350971222,
0.02046630159020424,
0.02354424074292183,
0.002385503612458706,
-0.010599181056022644,
-0.015057242475450039,
0.005617773160338402,
0.014887453988194466,
-0.002874021651223302,
-0.012240463867783546,
0.01715271919965744,
0.003217254066839814,
-0.01479427795857191,
-0.016754768788814545,
0.006619601044803858,
-0.004216196481138468,
0.023385964334011078,
0.005840769503265619,
0.0028712968342006207,
-0.020216960459947586,
0.007455821149051189,
0.001282388810068369,
0.02207818254828453,
0.002619844861328602,
0.008503218181431293,
0.002238140907138586,
-0.02820805460214615,
-0.0038726814091205597,
0.008424957282841206,
-0.02726595476269722,
-0.01597609370946884,
0.006617630831897259,
0.004051073919981718,
-0.004392029717564583,
-0.017495140433311462,
-0.006166319828480482,
-0.016002483665943146,
0.0038928354624658823,
-0.007222934626042843,
-0.009338369593024254,
-0.013287548907101154,
-0.008895288221538067,
0.02886613830924034,
0.02414008043706417,
-0.015769705176353455,
0.0037325310986489058,
0.014208822511136532,
-0.02298203855752945,
0.0016666362062096596,
-0.004915403202176094,
-0.017055490985512733,
-0.012241882272064686,
-0.01129346527159214,
0.0009759513195604086,
-0.022950122132897377,
0.011661555618047714,
-0.0008187871426343918
] | [
0.5947146415710449,
-0.1904607117176056,
-0.3095855116844177,
-0.07777480036020279,
-0.26396891474723816,
-0.07991725951433182,
0.09504271298646927,
-0.07126860320568085,
-0.07822585105895996,
-0.5918647646903992,
-0.3774612247943878,
0.033532917499542236,
-0.8519414663314819,
0.43596702814102173,
-0.29025018215179443,
0.96564120054245,
0.7443162798881531,
0.23691090941429138,
-0.28229060769081116,
0.02262687496840954,
-0.09051837027072906,
0.5184530019760132,
0.22671622037887573,
-0.009157693013548851,
0.08092203736305237,
0.12896054983139038,
0.6934658885002136,
0.45372527837753296,
0.007551266811788082,
0.3495221436023712,
-0.029764210805296898,
0.8476159572601318,
-0.3110104501247406,
0.12253449857234955,
-0.38181042671203613,
0.06462880969047546,
0.1440361589193344,
-0.19937896728515625,
0.34399303793907166,
-0.33383241295814514,
0.5210670232772827,
-0.17218272387981415,
-0.190262109041214,
0.42669883370399475,
-0.8732709884643555,
-0.43083614110946655,
-1.773013949394226,
0.3934771716594696,
-0.4232662618160248,
-0.14939400553703308,
0.39321058988571167,
0.06410831212997437,
0.17604754865169525,
0.504447877407074,
-0.3225356340408325,
0.3613496720790863,
-0.009707250632345676,
0.17123566567897797,
0.40377843379974365,
-0.3810473680496216,
0.6396360397338867,
0.03340528905391693,
0.12729564309120178,
0.09377569705247879,
0.27565717697143555,
0.3694968521595001,
0.16858920454978943,
-0.004512449260801077,
-0.543601930141449,
-0.35866579413414,
-0.22804869711399078,
-0.08413656800985336,
-0.2318887710571289,
0.30128443241119385,
-0.6257506608963013,
0.49576443433761597,
-0.2724241614341736,
-0.2136688530445099,
0.19573011994361877,
-0.16999396681785583,
-0.1948140263557434,
-0.04616090655326843,
0.05185987800359726,
-0.5195993781089783,
0.25152966380119324,
-0.324786901473999,
-0.3722878396511078,
0.4887535572052002,
-0.32771748304367065,
0.4522607922554016,
-0.4112119972705841,
-0.37657734751701355,
0.7978702783584595,
0.2392556220293045,
0.7836317420005798,
-0.05562520772218704,
0.5149924755096436,
-0.43185606598854065,
0.036532774567604065,
-0.050340041518211365,
-0.2899085283279419,
-0.05892112851142883,
-0.286259263753891,
-0.1837872862815857,
-0.9287294745445251,
-0.4029100835323334,
-0.1871219128370285,
-0.804523229598999,
-0.07804916054010391,
0.5383809804916382,
-0.5751855969429016,
0.4162970185279846,
-0.18450932204723358,
-0.1193656250834465,
-0.4765148460865021,
-0.06871981173753738,
0.02326679602265358,
-0.009354420937597752,
0.19046643376350403,
0.6382254958152771,
-0.4246717691421509,
0.9428704380989075,
-0.3416278064250946,
0.05856179818511009,
0.23827752470970154,
-0.0910019800066948,
0.5578323602676392,
0.17984041571617126,
-0.5367752909660339,
0.23934079706668854,
0.158713698387146,
0.4439215660095215,
0.22376923263072968,
0.18278422951698303,
0.045816902071237564,
-0.8500194549560547,
-0.03681819885969162,
-0.4970077872276306,
-0.4529501795768738,
-0.1805330216884613,
-0.21930213272571564,
-0.387206107378006,
-0.6910878419876099,
-0.3356221914291382,
0.2640541195869446,
-0.25269651412963867,
-0.2057233303785324,
0.02218613773584366,
-0.17477498948574066,
-0.437243789434433,
0.06688596308231354,
0.10925653576850891,
-0.32720762491226196,
0.09855752438306808,
-0.08722987025976181,
0.06374823302030563,
-0.3901083767414093,
-0.1309671550989151,
-0.04901209846138954,
0.12417221069335938,
0.046014294028282166,
-0.13283634185791016,
-0.19454239308834076,
-0.3648858368396759,
0.38434043526649475,
-0.7949916124343872,
0.14577625691890717,
0.5834234952926636,
-0.23249557614326477,
0.06874049454927444,
-0.1915310174226761,
-0.31804680824279785,
-0.11632734537124634,
0.1698857545852661,
-0.31504735350608826,
0.05048878490924835,
0.4489630460739136,
0.06818431615829468,
0.4710381329059601,
-0.15868152678012848,
-0.4674011468887329,
-0.8099508285522461,
0.17760111391544342,
0.03885428607463837,
0.22554978728294373,
0.013688630424439907,
0.15911807119846344,
-0.13301199674606323,
-0.1128302812576294,
0.34550777077674866,
0.10248676687479019,
-0.5363028645515442,
-0.12318349629640579,
-0.9757080078125,
0.9942399859428406,
-0.280001699924469,
-0.40486013889312744,
0.8213792443275452,
-0.10014551132917404,
-0.18203097581863403,
-0.36261874437332153,
0.08249249309301376,
0.1639527678489685,
-0.09828758984804153,
-0.09061453491449356,
0.002265062415972352,
0.14999641478061676,
-0.006550129968672991,
-0.5398359894752502,
0.016606241464614868,
0.47102683782577515,
0.006296093575656414,
0.044127222150564194,
-0.01645486243069172,
-0.06489868462085724,
0.2248622477054596,
-0.42042428255081177,
0.14674533903598785,
-0.00023746774240862578,
0.2852283716201782,
0.7709318399429321,
-0.2749232053756714,
0.33726927638053894,
-0.03879421949386597,
0.43773725628852844,
0.16846071183681488,
0.9846928715705872,
0.5488764047622681,
0.8867571949958801,
-0.04349913448095322,
0.12990228831768036,
-0.25364843010902405,
0.7718954682350159,
-0.3841438591480255,
-0.274192214012146,
0.08981961756944656,
0.2595402002334595,
-0.09325957298278809,
0.1623120754957199,
-0.30977872014045715,
-0.03933728113770485,
0.34372299909591675,
-0.6217478513717651,
0.22284388542175293,
-0.1377016007900238,
0.09931770712137222,
-0.27733707427978516,
0.3376722037792206,
-0.4487536549568176,
0.19477881491184235,
0.36496779322624207,
0.3752497434616089,
0.4780353307723999,
-0.49985751509666443,
0.2070913165807724,
0.1949661523103714,
0.04563746973872185,
-0.42932236194610596,
0.23846738040447235,
-0.15371471643447876,
-0.3584898114204407,
-0.6516380310058594,
-0.12589499354362488,
-0.3987904489040375,
-0.4743190407752991,
-0.2941547632217407,
-0.6711682081222534,
-0.23446711897850037,
0.43053898215293884,
0.436404824256897,
0.41424864530563354,
0.22924819588661194,
-0.24220606684684753,
0.4662179946899414,
-0.33556637167930603,
-0.7761266827583313,
0.274822473526001,
0.0010409700917080045,
-0.3977241814136505,
-0.2978169918060303,
-0.11803507059812546,
0.3372492790222168,
0.6585575938224792,
-0.16672444343566895,
-0.5946495532989502,
-0.5821864604949951,
0.5400890111923218,
-0.3409823775291443,
-0.25378280878067017,
-0.15435391664505005,
-0.2404971420764923,
0.4707449674606323,
0.019905492663383484,
-0.7332615852355957,
0.23429127037525177,
0.17197151482105255,
-0.2046954482793808,
0.26640284061431885,
-0.18494075536727905,
-0.08341021090745926,
-0.12895269691944122,
0.26611265540122986,
-0.2711270749568939,
-0.33412107825279236,
0.3652460277080536,
-0.2124824821949005,
-0.6352548003196716,
0.8546884059906006,
-5.972105503082275,
0.20961660146713257,
-0.40880709886550903,
0.2057618647813797,
-0.6772997379302979,
-0.25589248538017273,
0.7869546413421631,
-0.06760556250810623,
-0.20715200901031494,
-0.2972107231616974,
-0.28710299730300903,
0.0429140068590641,
0.07901511341333389,
0.9277724623680115,
0.44536834955215454,
0.14864787459373474,
0.46520116925239563,
0.21108339726924896,
0.07018276304006577,
0.9337937831878662,
-0.015440419316291809,
-0.1920953243970871,
-0.06550363451242447,
0.5418424606323242,
0.1738629937171936,
-0.06529618799686432,
-0.31193310022354126,
0.24486993253231049,
0.03860045596957207,
-0.19179381430149078,
0.33659258484840393,
0.03626098856329918,
-0.6790012717247009,
-0.4577052593231201,
0.7510437369346619,
0.6208522319793701,
-0.02484016865491867,
-0.17154698073863983,
0.35152822732925415,
0.09574177116155624,
0.4638833999633789,
0.6526973843574524,
-0.25693488121032715,
-0.409274160861969,
0.03487782180309296,
0.010480670258402824,
-0.39032185077667236,
0.3444056510925293,
-0.8073515295982361,
0.5885798335075378,
-0.18647609651088715,
-0.09009715914726257,
0.16864658892154694,
-0.2165747880935669,
-0.2934533655643463,
0.013945531100034714,
0.17517971992492676,
0.11348085850477219,
-0.5518901348114014,
-0.06895986199378967,
0.2871580719947815,
-0.21139372885227203,
0.13013584911823273,
-0.32638323307037354,
-0.5931195020675659,
0.17362654209136963,
-0.907216489315033,
-0.5922961235046387,
0.2575315535068512,
0.18287448585033417,
-0.3925013244152069,
0.050016701221466064,
0.03376935049891472,
-0.6825771927833557,
0.25503405928611755,
-0.15607616305351257,
-0.1751255840063095,
0.12864868342876434,
0.009182834066450596,
0.7386058568954468,
-0.47256597876548767,
-0.17406144738197327,
-0.18697163462638855,
0.3216075599193573,
0.0817706361413002,
-0.7031924724578857,
-0.2696838676929474,
0.49205949902534485,
-0.48235493898391724,
-0.1424359828233719,
0.42914721369743347,
-0.5270641446113586,
0.35571858286857605,
0.42493686079978943,
0.32144758105278015,
0.6109008193016052,
0.3460956811904907,
0.22936055064201355,
0.5472959876060486,
-0.2922690510749817,
1.0793137550354004,
-0.582947850227356,
-0.1805417239665985,
-0.5872292518615723,
0.2518906891345978,
0.055888622999191284,
-0.45746493339538574,
0.21422651410102844,
0.6463056802749634,
-0.4903455674648285,
0.1385403573513031,
-0.00012212389265187085,
-0.5541591644287109,
-0.16868090629577637,
1.002922773361206,
-0.08302152156829834,
-0.5037034153938293,
0.05870268866419792,
0.507830023765564,
0.12968243658542633,
-0.00828786101192236,
0.10353637486696243,
-0.6026690602302551,
0.14128831028938293,
-0.27079370617866516,
-0.16012118756771088,
-0.518368124961853,
0.3805275857448578,
-0.44897544384002686,
0.22728896141052246,
0.663722038269043,
0.605539858341217,
-0.1502402424812317,
0.22810563445091248,
0.36672136187553406,
0.028434623032808304,
0.2164248824119568,
0.028445197269320488,
0.10519213229417801,
-0.8607376217842102,
0.6989891529083252,
0.13910506665706635,
-0.022859741002321243,
-0.04904841631650925,
0.30276575684547424,
0.348950058221817,
-0.1600641906261444,
0.1393120437860489,
-0.16082987189292908,
-0.18579868972301483,
0.11708323657512665,
-0.49258601665496826,
-0.22855429351329803,
-0.25308841466903687,
-0.26894083619117737,
0.41408997774124146,
0.7225116491317749,
0.3610634505748749,
0.24614684283733368,
-0.3665742874145508,
0.27563023567199707,
-0.4672909379005432,
-0.9055554866790771,
-0.03736255317926407,
-0.18922562897205353,
0.23171237111091614,
-0.4860649108886719,
0.33411598205566406,
-0.19244666397571564,
0.6179271340370178,
-0.15087006986141205,
-0.258964866399765,
0.1090262308716774,
-0.2946113049983978,
0.056006528437137604,
0.2709340751171112,
0.011664727702736855,
-0.132080540060997,
-0.2563222348690033,
0.0004353586118668318,
-0.058598555624485016,
-0.7596637010574341,
-0.4477710723876953,
0.44908618927001953,
0.4351099729537964,
0.3983120322227478,
-0.11868144571781158,
0.18823912739753723,
-0.3919701874256134,
-0.4992862343788147,
0.5600802898406982,
-0.15484535694122314,
0.29157501459121704,
-0.0051243663765490055,
0.17800812423229218,
-0.2764882743358612,
0.17924654483795166,
-0.14118734002113342,
-0.2842140793800354,
-0.5435398817062378,
0.23641861975193024,
0.3805510699748993,
-0.5168595314025879,
0.4276023209095001,
0.050309598445892334,
-0.2076350301504135,
-0.02574220485985279,
-0.0631624311208725,
-0.5560694932937622,
0.12568116188049316,
-0.38934749364852905,
-0.5148729085922241,
-0.2752947211265564,
-0.24030950665473938,
-0.3725273311138153,
0.38380002975463867,
-0.135982945561409,
-0.1768500655889511,
-0.10885440558195114,
-0.023600123822689056,
0.09870714694261551,
-0.04522758349776268,
0.11129813641309738,
-0.2898329496383667,
0.13396583497524261,
-0.4745945632457733,
0.4646929204463959,
-0.38647666573524475,
0.0903676226735115,
-0.04062165319919586,
0.06435377150774002,
0.26172053813934326,
-0.08763489127159119,
0.00007568329601781443,
-0.3103604018688202,
-0.6150219440460205,
-0.38166549801826477,
0.4303329288959503,
-0.010067535564303398,
-0.15002946555614471,
0.056325335055589676,
0.15726281702518463,
0.08194438368082047,
-0.2564748227596283,
-0.330716609954834,
-0.16655081510543823,
0.6604483127593994,
-0.05834643542766571,
-0.5704821944236755,
-0.2282559871673584,
-0.3029610216617584,
-0.15619973838329315,
0.1485385000705719,
0.5300261378288269,
0.7490237355232239,
0.12511178851127625,
-0.10362595319747925,
-0.49741530418395996,
-0.06493858247995377,
0.4549393951892853,
0.18694593012332916,
-0.1289716362953186,
-0.4166877567768097,
-0.38509601354599,
-0.031716424971818924,
-0.035447947680950165,
-0.4011409878730774,
-0.5047121047973633,
0.2577964961528778,
-0.4395195245742798,
0.5881131887435913,
0.24838759005069733,
0.32400810718536377,
0.3428327143192291,
0.29904788732528687,
0.061702169477939606,
-0.1928645819425583,
0.28930842876434326,
-0.45325958728790283,
0.16205909848213196,
-0.0928432047367096,
-0.27621588110923767,
0.5314790606498718,
-0.4223226010799408,
0.34945568442344666,
-0.6650139689445496,
0.012689840979874134,
0.23547744750976562,
-0.12718132138252258,
-0.17955096065998077,
-0.29144737124443054,
-0.19353406131267548,
-0.3923605978488922,
-0.5736274719238281,
-0.23714298009872437,
-0.09867081791162491,
0.12225954979658127,
-0.020730555057525635,
-0.169749453663826,
-0.22666046023368835,
-0.19121378660202026,
0.3416528105735779,
0.3367365300655365,
-0.2621863782405853,
0.19328834116458893,
0.26580920815467834,
0.5971354842185974,
0.4211609363555908,
-0.1072191596031189,
-0.28187456727027893,
0.5146685242652893,
0.25668349862098694,
0.5319980382919312,
0.49050506949424744,
-0.9589639902114868,
0.10710840672254562,
0.5542537569999695,
0.11093132942914963,
1.1038676500320435,
0.40023788809776306,
-0.035503409802913666,
0.45297807455062866,
0.8529911041259766,
-0.09855824708938599,
-0.6947081685066223,
0.21842646598815918,
0.0573316290974617,
0.39826685190200806,
0.14431464672088623,
0.2344808280467987,
0.45392653346061707,
0.6556668281555176,
-0.27842068672180176,
0.1316150426864624,
0.1638110727071762,
-0.04145302250981331,
0.16603995859622955,
0.10117406398057938,
-0.4457617402076721,
0.4044298231601715,
0.27768614888191223,
0.5012573599815369,
-0.05820872262120247,
0.4835778772830963,
-0.06899001449346542,
0.27776405215263367,
-0.23729439079761505,
0.05691323056817055,
-0.2230372279882431,
0.3854423463344574,
0.10118507593870163,
-0.11808467656373978,
-0.21854747831821442,
0.2730066776275635,
-0.2396727055311203,
-0.5122866630554199,
0.654431164264679,
-0.7034435868263245,
-0.587632954120636,
0.22580204904079437,
0.29142308235168457,
0.7490715384483337,
-0.24790076911449432,
0.17864170670509338,
-0.3048440217971802,
0.05280731990933418,
0.6429585814476013,
0.033165838569402695,
0.19235959649085999,
-0.055892977863550186,
-0.3284739553928375,
-0.07351532578468323,
-0.15896551311016083,
0.13106675446033478,
0.10556309670209885,
-0.5953318476676941,
0.43844375014305115,
0.2464880496263504,
-0.1843564659357071,
0.5445579886436462,
0.28089842200279236,
0.5622974634170532,
-0.5466530919075012,
-0.7976032495498657,
0.2557869553565979,
0.010104648768901825,
-0.0496504046022892,
0.1991250365972519,
-0.2815525531768799,
0.31124207377433777,
0.5369901657104492,
-0.8536345958709717,
-0.606303334236145,
0.1372477263212204,
-0.007546112406998873,
-0.13883116841316223,
-0.007694436237215996,
0.4459867775440216,
0.47394710779190063,
-0.47932782769203186,
0.043837402015924454,
-0.08840853720903397,
0.41188162565231323,
0.4151516854763031,
-0.5111028552055359,
0.3744942247867584,
-0.3202023506164551,
-0.11905347555875778,
-0.2742995321750641,
0.2766719162464142,
0.5112164616584778,
-0.22834794223308563,
-0.22459104657173157,
0.36121875047683716,
0.14749734103679657,
0.5082101821899414,
0.25993260741233826,
-0.18508419394493103,
-0.021712398156523705,
-0.12840986251831055,
0.11554545164108276,
-0.42344051599502563,
0.30543121695518494,
0.34851551055908203,
-0.07645687460899353,
-0.10784346610307693,
-0.21139390766620636,
0.1592506617307663,
-0.47361594438552856,
0.674644410610199,
-0.06557343900203705,
-0.23667147755622864,
0.04298686981201172,
0.3281039595603943,
-0.8890068531036377,
-0.4805910885334015,
0.18593792617321014,
-0.1632077991962433,
0.17343050241470337,
-0.06278716772794724,
-0.6338961124420166,
-0.13454774022102356,
-0.03926454111933708,
0.1014590933918953,
0.12916547060012817,
0.4821774363517761,
-0.00625581806525588,
-0.22557057440280914,
-0.3539991080760956,
0.6995910406112671,
-0.10177050530910492,
0.6289266347885132,
-0.2403867542743683,
0.09060576558113098,
-0.5106313824653625,
0.1516970843076706,
0.21559195220470428,
-0.37528684735298157,
0.1492515653371811,
0.1528272181749344
] |
The objective of the present study was to examine consumer preference and consumption behaviour with respect to the health benefits of wine for two contextually and culturally diverse consumer groups, namely Koreans and Australians. Participants were required to be wine consumers over the age of 18. Responses were collected by means of an online questionnaire. The results indicated that perceived health benefits of red wine were higher in the Australian sample than the Korean sample. Similarly, Australian consumers had more health related wine knowledge than Korean consumers. Red wine was the preferred wine style for both Korean and Australian consumers; however, the proportion of preference for red wine was significantly higher in the Korean sample. With respect to the expenditure on wine products, AUD$11–$19 was the preferred price range for both groups. The results also indicated that health-oriented wine is more attractive to Korean consumers than Australian consumers. In relation to gender, Korean women preferred red wine as much as men, but Australian women consumed significantly more white wine than men. Such findings inform winemakers and wine marketers on the appropriateness of weighting wine production and marketing to health aspects in order to maximize consumer | [
-0.00043429271318018436,
0.00674299756065011,
-0.02569148875772953,
0.03173574060201645,
0.0008061230182647705,
-0.0027975570410490036,
0.011908305808901787,
-0.01613996922969818,
-0.01750841736793518,
-0.004648211412131786,
-0.0026792320422828197,
0.013482894748449326,
0.009712882339954376,
0.008987387642264366,
-0.004187838640064001,
-0.026586785912513733,
-0.03840461000800133,
0.024414867162704468,
0.000057446653954684734,
0.02291538566350937,
0.0034010708332061768,
0.009614907205104828,
0.010232126340270042,
-0.038783758878707886,
0.008949493989348412,
0.022581221535801888,
0.004470466170459986,
-0.01542358286678791,
-0.035902999341487885,
-0.023627493530511856,
0.0005395552143454552,
0.000042949337512254715,
-0.004149927292019129,
-0.01748804748058319,
0.012815856374800205,
-0.025191646069288254,
0.003632619045674801,
0.031281400471925735,
0.020405251532793045,
-0.001777807017788291,
0.01105670165270567,
0.00042932014912366867,
0.0003612569998949766,
0.007961439900100231,
-0.005133029073476791,
-0.016417989507317543,
-0.00936274416744709,
0.025778409093618393,
-0.0156400166451931,
0.015679769217967987,
-0.009780973196029663,
0.0018989788368344307,
-0.008436145260930061,
-0.02761591412127018,
-0.007062502671033144,
-0.01265683863312006,
0.017334194853901863,
0.019691264256834984,
0.01234610565006733,
-0.028305374085903168,
0.0009817754616960883,
-0.009270802140235901,
-0.009410474449396133,
-0.011738043278455734,
-0.009916748851537704,
-0.06660347431898117,
-0.025599734857678413,
0.0022295797243714333,
0.005813081748783588,
-0.0114325862377882,
-0.029911689460277557,
0.007187669165432453,
-0.009033827111124992,
-0.013654820621013641,
-0.034062933176755905,
0.021318987011909485,
0.008169347420334816,
0.008586847223341465,
0.012778508476912975,
0.0009858496487140656,
-0.02074417844414711,
0.012194652110338211,
0.01081335823982954,
0.027299918234348297,
0.021478421986103058,
0.006298649124801159,
-0.0004633227363228798,
-0.015972217544913292,
-0.016880599781870842,
0.017252100631594658,
-0.02812255173921585,
-0.009680570103228092,
-0.013270117342472076,
0.005934089422225952,
-0.020970812067389488,
-0.02805718593299389,
0.009936871938407421,
0.007171042263507843,
0.02084127813577652,
-0.05381804704666138,
0.00650148605927825,
0.009392347186803818,
0.025261778384447098,
0.040134627372026443,
-0.030442455783486366,
0.019047914072871208,
0.032643869519233704,
0.026359708979725838,
0.00028585479594767094,
0.0026566002052277327,
-0.012997312471270561,
-0.0014156010001897812,
0.009125998243689537,
-0.00044941785745322704,
0.0027254149317741394,
0.0001936794724315405,
0.0003774203360080719,
0.003674621693789959,
0.0037731218617409468,
0.0016104369424283504,
0.008889018557965755,
-0.010232323780655861,
0.0044087693095207214,
-0.014228287152945995,
-0.0003456622071098536,
0.006791828200221062,
0.0023445531260222197,
-0.01041644811630249,
-0.030434461310505867,
-0.015390051528811455,
-0.012598550878465176,
-0.004315915517508984,
-0.00818729493767023,
0.0011968055041506886,
-0.006640707608312368,
-0.011883084662258625,
0.016114670783281326,
-0.018060903996229172,
-0.021511763334274292,
-0.01341154333204031,
-0.01804070919752121,
0.009853756055235863,
-0.0035109641030430794,
0.012713446281850338,
-0.010102644562721252,
-0.013972061686217785,
-0.0361110158264637,
0.028712233528494835,
0.008094264194369316,
0.0005026281578466296,
-0.008441634476184845,
-0.03124335967004299,
0.017108295112848282,
-0.007623040117323399,
-0.011676350608468056,
-0.023599188774824142,
-0.0064897844567894936,
-0.028360670432448387,
-0.011662197299301624,
-0.005548901855945587,
-0.03495696187019348,
0.009027939289808273,
0.041680872440338135,
0.010631315410137177,
0.028025232255458832,
-0.016277970746159554,
0.006374341901391745,
-0.034656353294849396,
-0.01359478197991848,
0.003732085693627596,
-0.016866493970155716,
0.00872858241200447,
0.028133774176239967,
0.012954100035130978,
0.007964028976857662,
-0.019656721502542496,
0.032458119094371796,
0.00894784927368164,
-0.008551307022571564,
0.06706461310386658,
-0.008976457640528679,
0.0537668839097023,
-0.012752948328852654,
0.030301976948976517,
0.0016175955533981323,
-0.009900860488414764,
0.04125212877988815,
-0.012656022794544697,
-0.022017139941453934,
-0.03015807643532753,
0.022829275578260422,
0.028246868401765823,
0.05974370986223221,
-0.02338431216776371,
-0.0405983105301857,
0.004454066511243582,
0.009682007133960724,
0.017036328092217445,
-0.01714128814637661,
0.003569220658391714,
-0.02448238618671894,
0.008595790714025497,
0.0006487639620900154,
-0.006435200572013855,
0.0017759613692760468,
0.007461282890290022,
0.020027680322527885,
0.01870368979871273,
0.012474484741687775,
0.0006887719500809908,
0.014840129762887955,
0.021993789821863174,
0.009411413222551346,
-0.01492270641028881,
-0.0021700714714825153,
-0.018165957182645798,
-0.0398641973733902,
0.03349793702363968,
-0.0016776341944932938,
-0.019761256873607635,
-0.004799267277121544,
-0.0043966276571154594,
-0.000297988997772336,
0.015545934438705444,
0.0025709858164191246,
-0.0006702877581119537,
0.012435611337423325,
0.008814660832285881,
-0.004360326565802097,
0.01065449882298708,
0.021350543946027756,
-0.023401949554681778,
-0.008406169712543488,
0.01216459646821022,
0.0215911827981472,
0.0186177846044302,
0.011981748044490814,
0.002747232560068369,
0.016833683475852013,
-0.012537194415926933,
0.0020207941997796297,
-0.03728969395160675,
-0.007748509757220745,
-0.028827138245105743,
0.03282869979739189,
-0.017885753884911537,
0.04336527734994888,
0.005915889050811529,
-0.02508188597857952,
0.017657503485679626,
0.0032486547715961933,
0.015305720269680023,
0.0028689787723124027,
0.005771690048277378,
0.01827201060950756,
-0.007793686352670193,
-0.050934627652168274,
-0.027698924764990807,
0.023610860109329224,
-0.014261240139603615,
0.024656429886817932,
0.009319731965661049,
-0.028658444061875343,
-0.003340895054861903,
0.03403381258249283,
-0.004985530860722065,
-0.008923618122935295,
0.034665193408727646,
0.0006756414659321308,
-0.03346061706542969,
0.0028839111328125,
-0.01497919112443924,
0.008773486129939556,
-0.08178946375846863,
-0.01694345660507679,
-0.02044059894979,
-0.018306748941540718,
0.003550546709448099,
-0.021334858611226082,
-0.010711721144616604,
-0.007348418235778809,
-0.009560151025652885,
-0.03417157381772995,
-0.01835235208272934,
0.013133009895682335,
-0.010117592290043831,
0.02216581255197525,
0.024422384798526764,
-0.004838904831558466,
0.013275841251015663,
0.0096655935049057,
-0.03794407844543457,
-0.027745921164751053,
-0.030469391494989395,
0.005574914626777172,
0.0032485630363225937,
0.015072405338287354,
-0.006266184616833925,
-0.021909527480602264,
0.009327402338385582,
-0.023093435913324356,
-0.023349085822701454,
-0.002957782242447138,
0.006893821991980076,
-0.021441377699375153,
-0.018722541630268097,
-0.005813467316329479,
-0.04221907630562782,
-0.0026621362194418907,
-0.018301207572221756,
0.004921404644846916,
-0.025314560160040855,
-0.012673484161496162,
0.006788427941501141,
-0.0006917857099324465,
0.004703613463789225,
-0.012814616784453392,
0.008926467970013618,
0.0053901709616184235,
-0.006169868167489767,
0.04882190376520157,
0.006251276470720768,
-0.019539274275302887,
0.009105238132178783,
-0.010970761999487877,
0.017640456557273865,
0.005000637378543615,
-0.016613243147730827,
-0.023898117244243622,
0.012623711489140987,
-0.006446877960115671,
-0.01129135675728321,
-0.008878309279680252,
-0.01226162537932396,
-0.011809823103249073,
-0.011638209223747253,
0.031102150678634644,
0.010534431785345078,
0.004185765981674194,
0.00891591515392065,
0.012229826301336288,
-0.0281342975795269,
0.013563048094511032,
-0.015933111310005188,
-0.0209809523075819,
0.007298448588699102,
-0.010217270813882351,
0.03961838409304619,
-0.013945861719548702,
-0.016217106953263283,
0.01328639779239893,
0.050455011427402496,
0.02526748925447464,
-0.043887097388505936,
-0.004190459847450256,
-0.02598826214671135,
-0.02388032153248787,
-0.011776675470173359,
-0.00027877395041286945,
0.002226857002824545,
-0.006960730999708176,
0.001390040386468172,
-0.015602517873048782,
-0.006719695869833231,
0.01837586611509323,
0.02354464866220951,
0.004397168755531311,
-0.0016829059459269047,
0.012572272680699825,
-0.013724920339882374,
-0.0024158216547220945,
0.005735970567911863,
0.010422119870781898,
0.027036841958761215,
-0.0017110822955146432,
-0.025485288351774216,
-0.014432013034820557,
0.02521071583032608,
0.008111066184937954,
-0.007129677105695009,
0.0242166705429554,
-0.0073150345124304295,
-0.012395782396197319,
-0.018059132620692253,
-0.008607601746916771,
-0.00426059914752841,
-0.016550172120332718,
0.021687280386686325,
-0.010160906240344048,
-0.027651119977235794,
-0.02411404624581337,
0.07174727320671082,
-0.015234190970659256,
0.023915927857160568,
-0.009492622688412666,
-0.006222456693649292,
0.008993187919259071,
-0.046400927007198334,
-0.01854921132326126,
-0.005265364423394203,
0.00738358311355114,
0.012468751519918442,
0.008192595094442368,
-0.004122494719922543,
-0.01822211779654026,
0.0021648064721375704,
0.018159106373786926,
0.0003687692806124687,
-0.010068527422845364,
0.02545897290110588,
-0.000828552758321166,
-0.005602584220468998,
0.019940955564379692,
-0.0012869926868006587,
-0.00776844285428524,
0.010623997077345848,
-0.018965641036629677,
-0.030214594677090645,
-0.011755864135921001,
-0.0009953578701242805,
-0.0013321160804480314,
0.01717395707964897,
0.016793400049209595,
-0.004962042439728975,
0.005221768282353878,
-0.020879782736301422,
0.016650687903165817,
0.008699978701770306,
-0.014378916472196579,
0.01312379539012909,
0.00274035707116127,
-0.018495425581932068,
-0.015484562143683434,
0.019511189311742783,
-0.002944896463304758,
-0.0022958265617489815,
0.004222804214805365,
-0.024206846952438354,
-0.00333261676132679,
-0.016846580430865288,
0.014865102246403694,
0.023056626319885254,
0.004665390122681856,
0.007550712674856186,
-0.032111700624227524,
-0.00721779465675354,
-0.009147373959422112,
0.02054181508719921,
0.004790856037288904,
-0.044885456562042236,
-0.010802940465509892,
0.012005455791950226,
-0.024140410125255585,
-0.026575325056910515,
-0.023946914821863174,
-0.02899455837905407,
0.002778424881398678,
-0.009033207781612873,
-0.012755900621414185,
-0.004624152556061745,
0.04128599911928177,
-0.007752635516226292,
0.01735330931842327,
-0.010180504992604256,
-0.0035781327169388533,
-0.01683814637362957,
-0.02372794598340988,
-0.02199304848909378,
0.015426628291606903,
-0.006410741247236729,
0.002778077032417059,
-0.026690151542425156,
-0.01225154846906662,
0.06799239665269852,
-0.0010294463718309999,
0.02152429148554802,
0.021280018612742424,
-0.021735642105340958,
-0.07360317558050156,
-0.029207199811935425,
0.02995285764336586,
-0.01196604035794735,
-0.04124383628368378,
0.03062361106276512,
-0.04804133623838425,
-0.013922987505793571,
-0.03839438781142235,
0.0013769719516858459,
-0.0030205335933715105,
0.031733036041259766,
-0.03238365426659584,
-0.030861422419548035,
0.012326467782258987,
-0.0024536720011383295,
0.02548139914870262,
0.008343808352947235,
0.002674650400876999,
0.03425363451242447,
0.0035728057846426964,
0.025231100618839264,
-0.05207357555627823,
0.006609078496694565,
-0.002450103871524334,
-0.08034196496009827,
-0.019316548481583595,
0.007715425919741392,
-0.030665475875139236,
-0.0073730978183448315,
0.005735626444220543,
0.01584445685148239,
-0.006696981843560934,
0.03864510357379913,
-0.01836346834897995,
-0.01895822584629059,
-0.01923259161412716,
0.022727645933628082,
0.0005882610566914082,
-0.01202543918043375,
-0.0019960885401815176,
0.011170491576194763,
-0.0007336325361393392,
-0.012074368074536324,
0.004267928656190634,
-0.0038150702603161335,
-0.0002852097386494279,
-0.006718705873936415,
0.015910357236862183,
-0.008212745189666748,
0.022636033594608307,
-0.02327708713710308,
0.009876414202153683,
-0.00821717083454132,
-0.002211657352745533,
0.02598845213651657,
0.02320343255996704,
-0.016760703176259995,
-0.02592349983751774,
-0.006452783942222595,
-0.01831009052693844,
0.0014569187769666314,
-0.01955152302980423,
-0.01823577471077442,
-0.004579490981996059,
-0.018347740173339844,
-0.021112143993377686,
0.04674026370048523,
0.031027106568217278,
-0.021550018340349197,
-0.01020820066332817,
0.009010770358145237,
-0.012847358360886574,
0.02149602770805359,
0.023935731500387192,
0.0055460697039961815,
0.00506879948079586,
-0.0015664221718907356,
-0.008291695266962051,
0.022134652361273766,
0.007475297898054123,
-0.012181492522358894,
0.014459369704127312,
-0.04182308912277222,
0.009141238406300545,
-0.015013528987765312,
-0.00010060647036880255,
-0.013954137451946735,
0.07220572233200073,
-0.012177202850580215,
0.004852275364100933,
0.017265602946281433,
-0.018393613398075104,
0.0011578338453546166,
-0.006898016668856144,
-0.011114692315459251,
0.005961175076663494,
0.014403289183974266,
0.013510786928236485,
-0.005652827210724354,
-0.04110921546816826,
0.007389966398477554,
0.016221461817622185,
-0.01569291390478611,
0.01203808281570673,
-0.027438856661319733,
0.0172641109675169,
-0.014321004040539265,
0.011210729368031025,
0.0039941174909472466,
-0.03297896310687065,
0.02647264115512371,
0.024544646963477135,
-0.0037344242446124554,
0.008600922301411629,
-0.025758203119039536,
0.0013706618919968605,
0.019486531615257263,
-0.03336247801780701,
-0.0155154038220644,
0.008756696246564388,
0.025586966425180435,
0.018900401890277863,
0.004802105948328972,
0.004120930097997189,
0.002736420836299658,
-0.015503209084272385,
0.003649562830105424,
0.009438487701117992,
-0.010239224880933762,
0.010446854867041111,
-0.05019904673099518,
0.016599301248788834,
-0.03967605531215668,
0.023422565311193466,
-0.012871220707893372,
0.013515711762011051,
0.01845003291964531,
0.005446553695946932,
0.006608979310840368,
-0.01570875570178032,
-0.0028549551498144865,
0.006116311065852642,
-0.020705461502075195,
-0.039606522768735886,
0.019087720662355423,
0.022465309128165245,
-0.0183904767036438,
-0.006032605655491352,
-0.007344144396483898,
0.011071588844060898,
-0.00652750488370657,
-0.017590263858437538,
0.04922585189342499,
0.0199761800467968,
-0.0008945887675508857,
-0.03557967394590378,
0.015497250482439995,
-0.012717952020466328,
0.004213912412524223,
0.009099566377699375,
-0.017491502687335014,
0.0053372555412352085,
-0.0035597854293882847,
0.0037210294976830482,
-0.05708254128694534,
0.011956187896430492,
0.02653292752802372,
0.000629425048828125,
0.007056679576635361,
-0.02222936600446701,
-0.02861892245709896,
-0.020220136269927025,
-0.0004223041469231248,
0.007568438071757555,
0.033116087317466736,
-0.011990769766271114,
0.010303715243935585,
-0.04591349512338638,
0.007783226668834686,
-0.0002105195017065853,
0.000394691014662385,
0.003729113144800067,
0.03542197495698929,
-0.011026784777641296,
0.013494353741407394,
0.03224869817495346,
0.00820869766175747,
0.01501762866973877,
0.0063502173870801926,
-0.012083420529961586,
0.021214857697486877,
0.008294529281556606,
-0.0036880008410662413,
0.0006384789012372494,
0.003921485971659422,
0.023785490542650223,
-0.04375336691737175,
-0.017974629998207092,
-0.02525995671749115,
0.01673469878733158,
0.004158481489866972,
-0.030545594170689583,
0.05391601100564003,
0.007803525310009718,
-0.04226557910442352,
0.006367470137774944,
-0.014245016500353813,
-0.015362057834863663,
-0.005721642170101404,
-0.02138797752559185,
0.01657192036509514,
0.003237362951040268,
0.008130542002618313,
-0.0169680193066597,
0.009005372412502766,
0.010476772673428059,
0.010703115724027157,
0.01766541600227356,
-0.040229521691799164,
0.009794805198907852,
-0.011772829107940197,
0.014118154533207417,
-0.007067888509482145,
-0.012672877870500088,
0.02090011164546013,
-0.03137055039405823,
-0.0010123373940587044,
0.03658248484134674,
0.0009662912925705314,
0.0028393734246492386,
0.007303356193006039,
0.007024179212749004,
-0.019709281623363495,
0.019001489505171776,
0.010004553943872452,
0.010328992269933224,
-0.00960886012762785,
0.017069609835743904,
0.010815782472491264,
-0.037163108587265015,
-0.00360072311013937,
-0.0008211834356188774,
0.009339040145277977,
0.0006197753828018904,
0.003583191428333521,
0.034655604511499405,
0.0015931385569274426,
-0.003725547343492508,
-0.016239792108535767,
0.002982729347422719,
0.03614204004406929,
0.01494753360748291,
-0.008733930066227913,
0.0009685116820037365,
-0.03215312957763672,
-0.010103841312229633,
0.019013918936252594,
0.004435364156961441,
-0.0333811491727829,
0.007949165999889374,
-0.0030882777646183968,
-0.030171770602464676,
-0.0005616082344204187,
0.0021156533621251583,
0.01238345354795456,
-0.006888647563755512,
0.010834291577339172,
-0.019765600562095642,
-0.038047485053539276,
-0.010232391767203808,
-0.01086697168648243,
-0.013680286705493927,
-0.012014491483569145,
0.006763418670743704,
0.002562955254688859,
0.007418012246489525,
0.02369852177798748,
0.010053092613816261,
-0.01367483101785183,
-0.023908700793981552,
0.005051774438470602,
0.00549315894022584,
-0.02599714696407318,
-0.029032902792096138,
0.003540061181411147,
0.0008714259602129459,
0.0008135904790833592,
0.017232466489076614,
-0.018633143976330757
] | [
0.3140672445297241,
0.34165382385253906,
0.32866528630256653,
-0.11763708293437958,
-0.46524447202682495,
0.6030344367027283,
0.5004921555519104,
-0.2625598609447479,
-0.01819687895476818,
-0.1814841479063034,
-0.13893914222717285,
0.5124106407165527,
0.44143328070640564,
-0.06259413063526154,
-0.04001288115978241,
0.7931563854217529,
0.8049418330192566,
0.3744364380836487,
0.13870419561862946,
-0.5442788600921631,
-0.565226137638092,
-0.43294796347618103,
0.32729238271713257,
-0.06351277232170105,
0.5493852496147156,
-0.39795899391174316,
0.8705613613128662,
0.1985093355178833,
0.014395457692444324,
-0.07151547074317932,
-0.22650840878486633,
0.55828458070755,
0.2674500346183777,
0.08336636424064636,
-0.22748810052871704,
0.47006720304489136,
0.019556144252419472,
-0.22163990139961243,
-0.0010719398269429803,
0.023134589195251465,
-0.36417463421821594,
-0.06403986364603043,
0.11704618483781815,
0.7972978949546814,
-0.10824928432703018,
-0.11811630427837372,
-1.3789618015289307,
0.22763372957706451,
0.0257432721555233,
0.31997576355934143,
0.1679239422082901,
0.2090626358985901,
0.0012285109842196107,
-0.16162893176078796,
0.08264540880918503,
0.2364926040172577,
-0.3906759023666382,
0.054239075630903244,
-0.1682715266942978,
-0.5798549056053162,
0.6936563849449158,
0.2743622660636902,
0.2901701331138611,
0.12958332896232605,
-0.5413376092910767,
-0.11291832476854324,
0.03946663439273834,
0.01350708119571209,
-0.24106258153915405,
0.11306310445070267,
-0.07108884304761887,
-0.30558642745018005,
-0.4575457274913788,
0.02507030963897705,
-0.2774560749530792,
-0.1357078105211258,
-0.2513117492198944,
0.024628283455967903,
0.07035251706838608,
-0.3306371569633484,
-0.04954603314399719,
-0.3034737706184387,
0.29066336154937744,
-0.34432274103164673,
0.45403310656547546,
0.22938667237758636,
0.013366952538490295,
-0.17936967313289642,
0.07733703404664993,
0.10889851301908493,
-0.590741753578186,
0.3862941861152649,
0.6019760370254517,
0.42558205127716064,
-0.1091613620519638,
0.0049558538012206554,
0.22614948451519012,
-0.10471875220537186,
0.3472963571548462,
-0.11574181914329529,
0.28195899724960327,
0.04279095306992531,
-0.16007326543331146,
0.14016102254390717,
-0.8572669625282288,
-0.315603107213974,
-0.08238550275564194,
-0.6513116955757141,
-0.45969921350479126,
0.052495941519737244,
-0.6261854767799377,
-0.05878910794854164,
-0.10824000090360641,
-0.017776677384972572,
-0.12576733529567719,
0.23759356141090393,
-0.2775190770626068,
-0.07618430256843567,
0.06388158351182938,
0.1806156039237976,
-0.2805851697921753,
0.1268596351146698,
-0.6249940395355225,
0.3098095953464508,
-0.061224233359098434,
0.05466454103589058,
0.5294429659843445,
0.3508470356464386,
-0.5009328126907349,
0.15209081768989563,
0.2568954527378082,
0.15937261283397675,
-0.19445815682411194,
-0.08862540125846863,
-0.5660752058029175,
-0.13806936144828796,
0.07004356384277344,
-0.11142823845148087,
-0.0461273156106472,
0.3180776834487915,
-0.5262784957885742,
-0.6574433445930481,
-0.33250877261161804,
-0.31709736585617065,
0.26634684205055237,
-0.4663200378417969,
-0.14536723494529724,
-0.2636360228061676,
-0.6750706434249878,
-0.0830434039235115,
-0.06411641091108322,
-0.06875220686197281,
-0.030665377154946327,
-0.03334910422563553,
0.06168224662542343,
0.7991407513618469,
-0.39834463596343994,
-0.0005928513128310442,
-0.02025527134537697,
-0.12605156004428864,
0.47030559182167053,
0.3248361647129059,
-0.2790254056453705,
-0.2169576734304428,
0.7916433215141296,
0.16387970745563507,
-0.4713270664215088,
0.7460731863975525,
-0.04586868733167648,
0.12693150341510773,
-0.29913264513015747,
0.08230558037757874,
0.07688097655773163,
-0.22458982467651367,
-0.6224815845489502,
0.03323381021618843,
0.03670842573046684,
0.20016449689865112,
0.19780513644218445,
0.18366463482379913,
-0.5821812152862549,
0.03494129702448845,
0.3304063081741333,
-0.10113582015037537,
0.2660505473613739,
-0.11878117173910141,
-0.22052578628063202,
-0.4997631907463074,
-0.2567698359489441,
0.2720819413661957,
-0.08359544724225998,
-0.8483527898788452,
0.5952879190444946,
-0.5485289096832275,
0.49539026618003845,
-0.6615731716156006,
-0.10601603984832764,
1.3972777128219604,
-0.2334269881248474,
0.02695957012474537,
-0.02299700677394867,
0.2583032548427582,
0.36228710412979126,
-0.0496508963406086,
-0.5796111226081848,
-0.13820236921310425,
0.03838009387254715,
-0.12884056568145752,
-0.32222220301628113,
0.5833168029785156,
-0.34907856583595276,
-0.20369583368301392,
-0.16263720393180847,
-0.06658332049846649,
0.0901673436164856,
0.6272401213645935,
0.05652691423892975,
0.16009242832660675,
-0.01268177479505539,
-0.2881786823272705,
0.7794293761253357,
0.19454821944236755,
0.23501695692539215,
0.09778503328561783,
-0.295983225107193,
0.3486563563346863,
0.5853667855262756,
0.3323984444141388,
0.24756136536598206,
-0.9014456272125244,
0.32166340947151184,
0.0005355242756195366,
0.6450459361076355,
-0.46675950288772583,
-0.10726027190685272,
0.16737011075019836,
-0.17022289335727692,
0.009592453017830849,
-0.13693223893642426,
-0.1075114831328392,
0.1244293600320816,
0.3647063374519348,
-0.09767764061689377,
0.30782151222229004,
-0.28192126750946045,
-0.29466912150382996,
-0.13790251314640045,
0.818830132484436,
-0.5545737147331238,
0.17619800567626953,
0.49336007237434387,
0.16388311982154846,
0.12283623963594437,
0.3514927923679352,
-0.26552268862724304,
-0.4342426061630249,
-0.235020250082016,
-0.5283862948417664,
0.2181677520275116,
-0.46183398365974426,
0.05899930000305176,
0.22876302897930145,
0.39926961064338684,
-0.00020147435134276748,
0.32664868235588074,
-0.3963768482208252,
-0.7421621680259705,
-0.7317938208580017,
0.2642647624015808,
1.0303291082382202,
0.26422417163848877,
0.0028158065397292376,
-0.6358988881111145,
0.30809465050697327,
0.004874367266893387,
0.06358204782009125,
-0.06339363753795624,
0.12408657371997833,
-0.2645886540412903,
-0.1509072184562683,
0.11123747378587723,
0.2930111587047577,
0.4513885974884033,
-0.47164905071258545,
-0.021841978654265404,
0.1432226300239563,
-0.5076915621757507,
-0.1308005154132843,
-0.15375587344169617,
-0.2524465322494507,
0.15629030764102936,
0.5982561707496643,
0.2275410294532776,
-0.3758006989955902,
0.7123458981513977,
-0.047510627657175064,
-0.32622411847114563,
0.992925763130188,
0.8080788254737854,
0.19943971931934357,
0.34301990270614624,
0.05913479998707771,
0.04693933203816414,
-0.05898779630661011,
0.24354560673236847,
0.1349155157804489,
-0.33682534098625183,
-0.0017413581954315305,
-6.178035259246826,
-0.2671009600162506,
-0.5529515147209167,
-0.30635780096054077,
-0.22252458333969116,
0.07256714999675751,
0.7743620872497559,
-0.5017616152763367,
0.058943524956703186,
0.17623984813690186,
0.19768980145454407,
0.25325313210487366,
-0.07037021964788437,
0.5921163558959961,
0.28646740317344666,
0.4588035047054291,
0.43307024240493774,
-0.5745055675506592,
-0.06614970415830612,
0.14952592551708221,
-0.05865677818655968,
-0.4198569059371948,
-0.3889017701148987,
0.4801042079925537,
0.17968349158763885,
0.2661963403224945,
-0.2123270183801651,
-0.11154539883136749,
-0.13784410059452057,
-0.28281813859939575,
-0.2933115065097809,
0.0021758240181952715,
-0.2053108811378479,
0.02435098960995674,
0.6087355613708496,
0.06878761202096939,
0.10991604626178741,
-0.008406473323702812,
0.0347643606364727,
-0.10667262971401215,
-0.3077560365200043,
0.11773186922073364,
-0.2896172106266022,
-0.16761134564876556,
0.07674360275268555,
-0.1447232961654663,
-0.4084863066673279,
0.40997785329818726,
-0.3805859386920929,
0.31553855538368225,
-0.09621214866638184,
0.43559959530830383,
0.13672779500484467,
0.36644670367240906,
-0.17630791664123535,
0.2136535346508026,
0.29720404744148254,
0.44040411710739136,
-0.05080479383468628,
0.028254469856619835,
-0.4911516010761261,
-0.23507021367549896,
0.06265034526586533,
-0.3659701347351074,
-0.47497668862342834,
0.08282718062400818,
-0.3570619821548462,
-0.28168389201164246,
-0.24755258858203888,
0.40021049976348877,
-0.30737540125846863,
-0.10778511315584183,
0.13466569781303406,
-0.9977623820304871,
0.12148721516132355,
-0.5385769009590149,
0.19541993737220764,
0.49936816096305847,
-0.0573703907430172,
0.014397731982171535,
0.16180166602134705,
0.14579680562019348,
0.2261207550764084,
0.05657946318387985,
-0.13908791542053223,
-0.585145890712738,
0.22153274714946747,
0.2755697965621948,
0.046191561967134476,
0.012946276925504208,
0.08543061465024948,
-0.43872302770614624,
0.11632149666547775,
0.348102867603302,
-0.179777130484581,
0.5115877985954285,
0.4207113981246948,
0.41927269101142883,
0.3114766478538513,
-0.19558045268058777,
0.4294499158859253,
-0.0028420581948012114,
-0.6194738149642944,
-0.5079067945480347,
-0.5394498705863953,
0.30470699071884155,
-0.4187649190425873,
0.29727494716644287,
0.7508907318115234,
-0.572574257850647,
0.2162286639213562,
-0.1092274859547615,
-0.11450663208961487,
0.4113549292087555,
0.6179391145706177,
-0.014258874580264091,
0.11575036495923996,
-0.001772762625478208,
0.4308185279369354,
0.17620335519313812,
0.28040939569473267,
-0.27346962690353394,
-0.711753249168396,
0.13160327076911926,
0.009246014058589935,
-0.35051125288009644,
-0.001347924000583589,
0.39947256445884705,
-0.9815346002578735,
0.4928606152534485,
0.11968591809272766,
0.39986467361450195,
-0.163598895072937,
0.009960976429283619,
0.16182370483875275,
-0.014344608411192894,
-0.011766483075916767,
0.03674670681357384,
0.48048079013824463,
-0.09520752727985382,
0.22533050179481506,
-0.07970979064702988,
-0.013720857910811901,
-0.32565367221832275,
-0.21991591155529022,
0.034227240830659866,
-0.14970342814922333,
-0.2663728892803192,
-0.25061455368995667,
-0.020806007087230682,
-0.47371822595596313,
-0.08059924840927124,
-0.12451715767383575,
0.33097732067108154,
-0.610629677772522,
-0.5149146318435669,
-0.060112617909908295,
0.1706230789422989,
0.02500966377556324,
-0.6890082955360413,
0.37690553069114685,
-0.6180029511451721,
-1.0971777439117432,
-0.24981847405433655,
0.4063677191734314,
-0.10463686287403107,
0.09179757535457611,
-0.14633063971996307,
-0.11709990352392197,
0.7917072772979736,
0.12984727323055267,
-0.47086185216903687,
-0.1348060965538025,
0.008342219516634941,
0.08671818673610687,
-0.38346341252326965,
0.09906833618879318,
-0.19369667768478394,
-0.14714331924915314,
0.14904829859733582,
0.22963780164718628,
0.17723163962364197,
-0.3008486330509186,
-0.020773155614733696,
0.4631780683994293,
0.07786078006029129,
-0.42171064019203186,
-0.41011419892311096,
0.14316155016422272,
0.1369362473487854,
-0.12158114463090897,
0.07788918167352676,
0.6728053092956543,
-0.11406148225069046,
-0.14380046725273132,
-0.3374810516834259,
-0.03327212855219841,
0.10431550443172455,
0.040226247161626816,
0.08835912495851517,
0.33502957224845886,
0.024744585156440735,
-0.44545355439186096,
0.18988037109375,
0.7261614799499512,
0.014462119899690151,
-0.36762019991874695,
0.0035761676263064146,
-0.4894684851169586,
-0.22965827584266663,
-0.13724544644355774,
-0.5499772429466248,
-0.5677226185798645,
0.10028702765703201,
-0.4735266864299774,
0.13351094722747803,
-0.2727690041065216,
-0.400526762008667,
0.13875873386859894,
0.18681560456752777,
0.09279674291610718,
-0.07133012264966965,
-0.7716215252876282,
-0.26916030049324036,
-0.027264326810836792,
-0.16831490397453308,
0.2623205780982971,
-0.6501744985580444,
-0.0630110651254654,
0.33728647232055664,
-0.3585064709186554,
0.1563577950000763,
0.5061153769493103,
0.43033087253570557,
-0.4459168612957001,
-0.42392459511756897,
-0.22419588267803192,
0.0964762344956398,
0.11535712331533432,
0.4841139316558838,
-0.08238936960697174,
0.8607058525085449,
0.2457263022661209,
-0.3725014925003052,
0.002116893883794546,
-0.13945424556732178,
0.044736165553331375,
-0.2967754304409027,
-0.5182534456253052,
-0.07466252893209457,
0.042676232755184174,
-0.6404953598976135,
0.35194236040115356,
0.11364270001649857,
-0.12953981757164001,
0.3360018730163574,
0.2651149332523346,
-0.10973317176103592,
0.1343086063861847,
0.4308438003063202,
0.03191959857940674,
-0.22274361550807953,
-0.09496885538101196,
0.03243018314242363,
0.5110710263252258,
0.1724974513053894,
-0.20345209538936615,
-0.9554854035377502,
0.2219458669424057,
0.0548628605902195,
0.4887348711490631,
-0.2555771470069885,
0.3244960308074951,
0.46152976155281067,
0.7552496790885925,
0.028878217563033104,
-0.4715753495693207,
-0.23279725015163422,
-0.1109541654586792,
0.005231976509094238,
0.14404809474945068,
-0.15430033206939697,
0.010464092716574669,
0.02019624598324299,
0.16145727038383484,
-0.5563107132911682,
0.24030905961990356,
-0.35447052121162415,
-0.8112667798995972,
-0.3479464650154114,
0.1841936856508255,
0.2798786759376526,
-0.650657057762146,
0.04500424861907959,
0.026302235201001167,
0.09078942984342575,
0.4388992190361023,
-0.15154501795768738,
-0.089118093252182,
-0.08585117012262344,
0.051266852766275406,
0.7517356872558594,
0.5609878897666931,
0.3077024519443512,
-0.0022407963406294584,
0.29000452160835266,
0.20171189308166504,
-0.08965566009283066,
0.17294420301914215,
0.26850542426109314,
0.2512074410915375,
-0.08421798795461655,
0.3804515600204468,
0.27393007278442383,
-0.7404201626777649,
-0.18557465076446533,
0.0008115112432278693,
-0.1785946637392044,
0.5380657315254211,
0.2798405587673187,
-0.3717147707939148,
0.12789659202098846,
0.5278065204620361,
0.2897164821624756,
-0.2911154627799988,
0.4363500475883484,
-0.21774324774742126,
0.14449314773082733,
0.6239497661590576,
0.6596927642822266,
-0.03779405727982521,
0.9918635487556458,
0.08821728080511093,
0.8142725229263306,
0.02833526022732258,
0.2914348244667053,
0.006027508992701769,
-0.576734185218811,
-0.19023126363754272,
0.38449013233184814,
0.6032528877258301,
0.17811961472034454,
0.09994057565927505,
-0.3590295910835266,
0.1101531833410263,
0.7195726037025452,
-0.34018996357917786,
-0.04609902575612068,
-0.2407377064228058,
0.38943037390708923,
0.3529840111732483,
-0.20832139253616333,
-0.08810043334960938,
0.6442869305610657,
-0.1149144172668457,
0.48881033062934875,
-0.177386075258255,
-0.3721170127391815,
-1.1377770900726318,
0.3863746225833893,
0.0985332578420639,
0.20135489106178284,
0.26923829317092896,
-0.33215516805648804,
-0.23675981163978577,
-0.10212977230548859,
0.30843406915664673,
0.2579135298728943,
-0.19558300077915192,
0.12478037178516388,
-0.036481451243162155,
0.04803111031651497,
-0.40742358565330505,
0.015480336733162403,
0.25662973523139954,
-0.1728009134531021,
0.07391230762004852,
-0.3500032424926758,
0.05265120416879654,
0.5176478028297424,
-0.3306117355823517,
-0.2282043993473053,
-0.2299470454454422,
-0.45914995670318604,
-0.5048206448554993,
0.06444698572158813,
-0.11832793056964874,
0.45344334840774536,
-0.17032571136951447,
0.007736235857009888,
0.012151448987424374,
-0.08191700279712677,
-0.06758245825767517,
0.34482428431510925,
-0.5158694386482239,
-0.24337877333164215,
-0.11620138585567474,
0.21265698969364166,
0.6331131458282471,
-0.4259178042411804,
-0.21137909591197968,
-0.2390117645263672,
-0.6233260631561279,
0.238917738199234,
-0.41461825370788574,
0.705865204334259,
-0.7482157349586487,
-0.16575020551681519,
-0.08139543235301971,
0.20793022215366364,
0.28067344427108765,
-0.07323167473077774,
0.09673748910427094,
-0.041811730712652206,
0.00029899776563979685,
0.7628646492958069,
0.663119375705719,
-0.14524522423744202,
0.27205967903137207,
-0.398075133562088,
-0.46372222900390625,
-0.5189734697341919,
0.39618512988090515,
0.25308534502983093,
-0.34528297185897827,
0.3274496793746948,
-0.07982160896062851,
0.44415509700775146,
-0.18720375001430511,
0.23152825236320496,
0.06006897613406181,
-0.16578052937984467,
-0.48221006989479065,
0.2777266502380371,
-0.7472612857818604,
0.033376000821590424,
0.4037989675998688,
0.3076077699661255,
0.1622464805841446,
0.18377408385276794,
-0.10863140225410461,
-0.35738667845726013,
0.3707107901573181,
-0.026836566627025604,
0.08587729930877686,
0.5067283511161804,
0.29040592908859253,
-0.19311894476413727,
-0.13568440079689026,
-0.04247906804084778,
-0.06796756386756897,
-0.5729275941848755,
-0.3214239180088043,
-0.3693256676197052,
-0.10253135114908218,
-0.32760339975357056,
-0.03171239793300629,
-0.3274739682674408,
0.030254626646637917,
-0.47064563632011414
] |
India and Israel have raised over US$35 billion by tapping into the wealth of their diaspora communities. These diaspora bonds represent a stable and cheap source of external finance, often when countries lost access to international capital markets. For diaspora investors, these bonds offer the opportunity to help their country of origin while also providing an investment opportunity. The potential for diaspora bonds is significant for many countries with large diasporas abroad. However, diaspora bond issuance from countries with weak governance and high sovereign risk may require support for institutional capacity building and credit enhancement from multilateral or bilateral agencies. Haiti, for instance, could raise several hundred million dollars by issuing diaspora bonds provided a guarantee structure is created to build trust in the country's public institutions. | [
-0.013040944002568722,
0.017926162108778954,
0.0024697729386389256,
0.025644294917583466,
0.004190215840935707,
0.001670844852924347,
0.009184034541249275,
0.010396908968687057,
-0.016093660145998,
0.009857981465756893,
-0.004691304638981819,
0.026705458760261536,
-0.010923834517598152,
0.00529761565849185,
-0.005316839087754488,
-0.010882927104830742,
0.006350246258080006,
0.00413481704890728,
0.004654519725590944,
-0.00041653309017419815,
-0.00747890817001462,
-0.028183767572045326,
0.010007021017372608,
0.0021912707015872,
-0.026570217683911324,
0.009868132881820202,
-0.007749608717858791,
-0.025146469473838806,
-0.0290195532143116,
0.008023042231798172,
-0.017514370381832123,
-0.0026898744981735945,
0.014771184884011745,
0.01629681885242462,
0.0071123214438557625,
-0.0122178103774786,
0.0008859115769155324,
0.030478758737444878,
0.015632161870598793,
-0.0028535344172269106,
0.03832561522722244,
-0.00335938879288733,
0.0006890265503898263,
-0.0020981174893677235,
-0.004926969762891531,
-0.0034838193096220493,
-0.006178469397127628,
-0.003628186648711562,
-0.007669799495488405,
0.009182779118418694,
-0.0032653140369802713,
0.023449182510375977,
-0.005222891923040152,
0.03616366162896156,
-0.006538402289152145,
0.0014187166234478354,
0.01972995325922966,
-0.009788713417947292,
-0.010072430595755577,
0.030318621546030045,
-0.006135992705821991,
-0.0205763578414917,
-0.015810735523700714,
0.003438580082729459,
-0.013965758495032787,
-0.06669352948665619,
-0.009319165721535683,
-0.004169735126197338,
0.003209030721336603,
-0.0274970680475235,
0.00563987297937274,
0.013640007935464382,
-0.012689687311649323,
0.02902183122932911,
0.0038751917891204357,
-0.010485242120921612,
0.004432404413819313,
0.026164712384343147,
0.002526723314076662,
0.020781302824616432,
-0.005149965174496174,
0.0013253604993224144,
-0.0028578019700944424,
-0.004498745314776897,
0.0285257026553154,
0.011988053098320961,
-0.028851835057139397,
0.01040716003626585,
0.018258817493915558,
-0.02250887081027031,
0.027991963550448418,
0.0034557762555778027,
0.000054593198001384735,
0.0058814543299376965,
0.008540449663996696,
-0.0055779945105314255,
0.007107420824468136,
-0.021601947024464607,
0.0077305324375629425,
0.01525782234966755,
-0.013678263872861862,
0.0032461448572576046,
0.011480040848255157,
-0.005487576127052307,
0.011215836741030216,
0.010007930919528008,
0.018654078245162964,
-0.0014050565659999847,
-0.015728935599327087,
0.00535030011087656,
0.017929695546627045,
-0.01797398179769516,
-0.02870890684425831,
-0.005759775638580322,
-0.02185579389333725,
-0.008026971481740475,
-0.016964789479970932,
0.009024569764733315,
0.004574157297611237,
-0.026717670261859894,
0.02878415212035179,
-0.017452865839004517,
-0.007604664657264948,
0.0013716835528612137,
0.0011865596752613783,
0.029134146869182587,
-0.033328890800476074,
-0.0018320514354854822,
0.017611302435398102,
0.020034879446029663,
-0.008893216960132122,
0.004704384133219719,
0.020718174055218697,
0.009464353322982788,
0.003266650717705488,
0.015044920146465302,
-0.021354660391807556,
-0.015907229855656624,
-0.0027203478384763002,
-0.022373421117663383,
0.020708028227090836,
0.014035526663064957,
-0.0030833445489406586,
0.006576241459697485,
0.0023852551821619272,
-0.013928791508078575,
0.00654905941337347,
-0.007350482512265444,
0.014350876212120056,
0.006900095380842686,
-0.003085895674303174,
-0.004266991280019283,
0.0008413735777139664,
-0.021213926374912262,
0.009508691728115082,
0.010479576885700226,
-0.008473221212625504,
-0.000421897042542696,
-0.02210777997970581,
0.018067708238959312,
-0.007827338762581348,
0.003724130569025874,
0.015265533700585365,
0.007123444229364395,
0.006447704508900642,
0.024805566295981407,
0.0179951973259449,
-0.019963975995779037,
0.005772002041339874,
0.008494623005390167,
-0.02212320640683174,
0.020658276975154877,
-0.01319509744644165,
0.01536838710308075,
0.003436479950323701,
0.0065576015040278435,
-0.013920247554779053,
0.007578379940241575,
-0.0023302892223000526,
0.06644399464130402,
-0.012286068871617317,
0.005594461690634489,
-0.030537044629454613,
-0.01215382106602192,
0.009796935133635998,
0.00119057297706604,
0.0073758503422141075,
-0.01973189041018486,
0.011795030906796455,
-0.0335552841424942,
0.016633396968245506,
0.0009081722237169743,
-0.027208853513002396,
-0.008404800668358803,
-0.012955954298377037,
0.00500481529161334,
0.014458006247878075,
0.0023481445387005806,
-0.01989107020199299,
0.008170553483068943,
0.018319111317396164,
-0.013935982249677181,
0.041660409420728683,
-0.03855910152196884,
0.029420893639326096,
0.0051234071142971516,
-0.0038056746125221252,
-0.01612856611609459,
-0.005784783512353897,
-0.0014577708207070827,
-0.0008909788448363543,
-0.013417733833193779,
0.008864052593708038,
-0.017174236476421356,
-0.023439569398760796,
-0.013483565300703049,
0.011151052080094814,
-0.022506162524223328,
0.002127045067027211,
-0.014581569470465183,
-0.013638071715831757,
0.04198876768350601,
-0.02370329760015011,
0.0033456129021942616,
0.021503930911421776,
0.010410664603114128,
0.00004932883894070983,
0.009896771982312202,
-0.01560748927295208,
0.008080109022557735,
0.030179953202605247,
-0.011970074847340584,
-0.008388897404074669,
-0.004385864362120628,
-0.021740641444921494,
0.016514915972948074,
0.009107911959290504,
0.020123019814491272,
0.016179215162992477,
-0.00922337919473648,
0.015003743581473827,
0.027022123336791992,
0.007095797453075647,
0.009957797825336456,
0.006528610363602638,
0.00918731838464737,
0.0015433314256370068,
0.016256999224424362,
0.032650500535964966,
0.01052461564540863,
0.007436126004904509,
-0.0013399480376392603,
0.01554940827190876,
0.044257353991270065,
0.0054208943620324135,
0.016240403056144714,
-0.0014807977713644505,
-0.035633593797683716,
0.0260019451379776,
-0.0032788636162877083,
0.013939005322754383,
0.005545799620449543,
-0.02998586930334568,
0.00884653627872467,
0.01097086537629366,
0.03076927363872528,
-0.02564232237637043,
0.016475845128297806,
0.03454802557826042,
-0.0025056488811969757,
0.002555239712819457,
0.00019630923634395003,
0.0010832974221557379,
-0.08180304616689682,
-0.0026146015152335167,
0.03875882551074028,
-0.014828143641352654,
0.013475333340466022,
-0.007544465363025665,
-0.0028836701530963182,
0.021113883703947067,
-0.013873906806111336,
-0.0003496615681797266,
0.036168135702610016,
0.028723256662487984,
-0.017980892211198807,
0.006885124836117029,
-0.00013488857075572014,
-0.0022277100943028927,
0.007080676034092903,
-0.0026639876887202263,
-0.022205762565135956,
-0.01016556192189455,
-0.0016823664773255587,
-0.020764650776982307,
0.00607386464253068,
-0.012085247784852982,
0.007492235861718655,
0.020459558814764023,
0.005568766966462135,
0.013659474439918995,
-0.018077880144119263,
0.015330436639487743,
-0.008898628875613213,
-0.012798963114619255,
0.01915069669485092,
-0.024308057501912117,
0.026431050151586533,
-0.009079690091311932,
0.007316403090953827,
-0.009027432650327682,
-0.01216264721006155,
0.005259053781628609,
0.032173361629247665,
0.029001059010624886,
0.0009887688793241978,
0.009051447734236717,
0.005358302965760231,
-0.016724377870559692,
-0.014643939211964607,
0.02130475640296936,
0.007177378050982952,
0.00962209515273571,
0.020227771252393723,
0.003560453187674284,
0.03295771777629852,
0.013350209221243858,
-0.01171180047094822,
0.014715955592691898,
-0.004421833902597427,
-0.013492120429873466,
-0.017029594630002975,
-0.005318689625710249,
0.0011639483273029327,
0.0012322114780545235,
0.008562019094824791,
-0.0045291949063539505,
-0.027093514800071716,
-0.025681864470243454,
0.007919276133179665,
0.018033815547823906,
-0.026061279699206352,
-0.010818530805408955,
-0.004352940246462822,
-0.015018577687442303,
-0.01741047576069832,
-0.0030494711827486753,
0.02232123166322708,
-0.0124056963250041,
-0.013595152646303177,
0.0009084225166589022,
0.020769570022821426,
0.00255155423656106,
0.0047560990788042545,
-0.01110803335905075,
-0.010921667329967022,
-0.013639714568853378,
-0.006056969985365868,
0.015828637406229973,
0.009332938119769096,
0.011576255783438683,
-0.0045842318795621395,
-0.009859548881649971,
0.019073959439992905,
0.012160723097622395,
0.040462642908096313,
-0.001554375165142119,
-0.022821951657533646,
-0.001050126738846302,
-0.021651489660143852,
-0.022995106875896454,
0.00004188995808362961,
0.010115157812833786,
-0.003173325676470995,
-0.011282285675406456,
-0.012326548807322979,
-0.012230432592332363,
-0.013085154816508293,
0.015157630667090416,
0.0016491299029439688,
-0.027521751821041107,
-0.002816945780068636,
-0.002638883888721466,
-0.017397064715623856,
-0.014188291504979134,
-0.0019972166046500206,
0.021650398150086403,
0.012712538242340088,
0.03647724166512489,
-0.008585594594478607,
-0.008359063416719437,
0.07230299711227417,
0.03313816338777542,
-0.0040409015491604805,
-0.012228654697537422,
-0.0011925252620130777,
0.00621845293790102,
-0.002758094808086753,
0.002573000732809305,
0.0005983104929327965,
-0.003270047716796398,
0.013624648563563824,
0.014637317508459091,
-0.016501683741807938,
-0.01034642569720745,
-0.00812491960823536,
0.005953822284936905,
-0.01681673526763916,
0.0122182946652174,
0.0050534033216536045,
0.032515376806259155,
-0.009402453899383545,
-0.006424514576792717,
-0.02562420442700386,
0.009508686140179634,
-0.02664058841764927,
-0.006778452545404434,
0.004449679050594568,
-0.006473182234913111,
-0.0024115298874676228,
0.00012051669182255864,
0.02114090882241726,
-0.021725576370954514,
-0.0026270633097738028,
-0.014776279218494892,
-0.00864521972835064,
-0.033729568123817444,
-0.006788792088627815,
-0.011529156006872654,
0.006172149442136288,
-0.016347404569387436,
-0.007346277125179768,
-0.011929161846637726,
-0.0059971618466079235,
0.014515425078570843,
-0.00752701610326767,
0.030548525974154472,
-0.026216302067041397,
-0.004172753542661667,
0.021145746111869812,
-0.017812669277191162,
0.012494678609073162,
0.008762648329138756,
0.012536891736090183,
-0.007210101466625929,
0.00854124128818512,
-0.004237130284309387,
0.010585837066173553,
-0.004531682003289461,
0.010720765218138695,
0.02740459330379963,
-0.02476389706134796,
0.02947702631354332,
-0.013616162352263927,
-0.011919530108571053,
-0.01202130876481533,
-0.02771000936627388,
0.033561475574970245,
-0.004670258611440659,
-0.0031681053806096315,
0.017710097134113312,
-0.006472496315836906,
-0.003777126781642437,
0.02100241929292679,
0.004972023889422417,
-0.01770792528986931,
-0.030990464612841606,
0.018298355862498283,
-0.020343348383903503,
-0.021905621513724327,
-0.0010115946643054485,
-0.03236838057637215,
0.017715582624077797,
-0.0004831980913877487,
0.007578201591968536,
0.00668998621404171,
-0.0009290138259530067,
-0.010159296914935112,
-0.07542149722576141,
-0.027752354741096497,
0.01768307574093342,
-0.0071242875419557095,
-0.011732610873878002,
-0.010040359571576118,
-0.013056090101599693,
0.0004396047443151474,
-0.009545935317873955,
-0.006652913521975279,
-0.01118137501180172,
-0.04949487745761871,
-0.0033088093623518944,
-0.00014103844296187162,
0.011960008181631565,
0.00020244007464498281,
-0.004304797388613224,
0.026275835931301117,
-0.012224478647112846,
-0.02339796908199787,
-0.001857689581811428,
0.0027571991086006165,
0.024988994002342224,
0.01428449060767889,
0.0021858150139451027,
-0.08115092664957047,
-0.01888423040509224,
0.011386709287762642,
0.017382808029651642,
-0.001841438701376319,
-0.002824339084327221,
-0.002197744557633996,
0.002646474866196513,
0.000008657574653625488,
-0.017589788883924484,
0.022385384887456894,
-0.004566635936498642,
-0.009113314561545849,
-0.017807375639677048,
-0.0005902387201786041,
-0.012634288519620895,
0.013352075591683388,
0.0008738837204873562,
-0.005917034111917019,
0.01753462664783001,
0.017486076802015305,
0.00045309029519557953,
-0.01151537336409092,
-0.0024530242662876844,
-0.010226636193692684,
0.0014806347899138927,
-0.005435090512037277,
0.01365111954510212,
0.011137569323182106,
0.013553338125348091,
-0.02617936208844185,
0.01490460243076086,
-0.008077901788055897,
0.009873508475720882,
0.01219094730913639,
-0.012909801676869392,
0.003746925387531519,
-0.005771181546151638,
0.035800106823444366,
-0.0014062945265322924,
-0.008901527151465416,
0.023174529895186424,
-0.013813382014632225,
0.056201402097940445,
0.004052952863276005,
0.008936107158660889,
0.010077785700559616,
0.002296656370162964,
0.01158552709966898,
0.007939942181110382,
0.017869707196950912,
-0.03558177128434181,
0.01198738906532526,
-0.03383636847138405,
-0.012636294588446617,
-0.020930178463459015,
0.003913435619324446,
0.0003034581895917654,
0.018558461219072342,
0.013464327901601791,
-0.003919609356671572,
-0.007081327959895134,
-0.005817864555865526,
0.07154695689678192,
-0.006343623623251915,
0.02512279897928238,
0.013398585841059685,
0.013128500431776047,
-0.004832866135984659,
-0.026258744299411774,
-0.009858828037977219,
-0.0026322416961193085,
-0.004234589636325836,
0.0162955354899168,
0.007169488817453384,
0.030881160870194435,
0.00726737268269062,
0.022880326956510544,
-0.01681167259812355,
0.0065127476118505,
-0.022064929828047752,
-0.021358124911785126,
0.030702859163284302,
-0.029757995158433914,
-0.021287113428115845,
-0.03049224242568016,
0.04058327153325081,
-0.003070713486522436,
-0.013278752565383911,
-0.0037747113965451717,
-0.02822529524564743,
-0.009353737346827984,
-0.01858598366379738,
0.0034388196654617786,
0.0015291599556803703,
0.005976075306534767,
-0.010676216334104538,
0.017306657508015633,
-0.00810446497052908,
0.02657550573348999,
0.0016143402317538857,
-0.011883861385285854,
0.006582049652934074,
-0.018649622797966003,
0.005002448335289955,
0.010553432628512383,
0.009624197147786617,
0.004104671534150839,
-0.05353657528758049,
0.004340429324656725,
-0.016442764550447464,
-0.006970580667257309,
0.009221630170941353,
0.025694478303194046,
0.0034839408472180367,
0.026806799694895744,
0.01984493061900139,
-0.015599661506712437,
-0.016563840210437775,
0.022299770265817642,
0.01628832519054413,
0.013723659329116344,
-0.019299780949950218,
-0.03988096863031387,
-0.00286992103792727,
-0.027388213202357292,
0.0040328665636479855,
0.014311878010630608,
-0.009275593794882298,
0.0010905886301770806,
-0.0026704000774770975,
-0.016374962404370308,
0.012663397006690502,
0.022211916744709015,
-0.004753898363560438,
0.004695824347436428,
-0.03133556246757507,
0.007051403168588877,
-0.004548087250441313,
0.0058523244224488735,
0.007987678050994873,
-0.000168938422575593,
0.003739555599167943,
-0.008478724397718906,
0.025293171405792236,
0.0034587171394377947,
0.0011349719716235995,
0.0070519400760531425,
-0.018780576065182686,
-0.010336128994822502,
-0.006874830927699804,
-0.00862879492342472,
0.005485521629452705,
0.017071740701794624,
-0.007233087904751301,
0.0002227054792456329,
0.024810703471302986,
0.011704659089446068,
0.03613229840993881,
0.0001074222382158041,
0.0100442785769701,
-0.026046691462397575,
-0.017504490911960602,
0.006767826154828072,
0.004547213204205036,
-0.004648322705179453,
0.004923926666378975,
-0.006778175011277199,
-0.010145911015570164,
0.0004167226143181324,
-0.004643406718969345,
-0.01217994187027216,
-0.011046534404158592,
-0.00141777447424829,
0.022645272314548492,
-0.018847540020942688,
-0.017476100474596024,
0.004692514427006245,
0.015741698443889618,
-0.023959919810295105,
0.049028508365154266,
0.00461573014035821,
-0.015585441142320633,
-0.011205978691577911,
-0.002471607644110918,
0.018363166600465775,
-0.009497402235865593,
-0.009279821068048477,
-0.020908523350954056,
-0.0076107969507575035,
-0.010453211143612862,
0.015988167375326157,
0.010483207181096077,
0.0055245887488126755,
-0.0035878419876098633,
-0.017439790070056915,
-0.014020252972841263,
-0.000002264394424855709,
0.010610408149659634,
0.01457531750202179,
-0.011697037145495415,
-0.01152584608644247,
-0.0348568931221962,
-0.02139466628432274,
-0.0029861165676265955,
0.012399127706885338,
-0.030209746211767197,
0.008853349834680557,
0.006353034172207117,
0.01115432009100914,
0.0043075112625956535,
0.01608819141983986,
0.0037351727951318026,
-0.0005327928811311722,
0.004124388098716736,
0.030474508181214333,
-0.0072571467608213425,
-0.014161193743348122,
0.017735574394464493,
0.007432508748024702,
-0.026028506457805634,
0.013542773202061653,
-0.008439651690423489,
-0.008861270733177662,
0.02942453697323799,
-0.004884554538875818,
0.022073758766055107,
0.0009827620815485716,
-0.030801545828580856,
-0.0011701135663315654,
0.0005916344234719872,
-0.006476930342614651,
0.006280316039919853,
-0.017354238778352737,
-0.008481458760797977,
-0.013337895274162292,
0.00047342199832201004,
-0.0007895691087469459,
-0.00591592863202095,
-0.014434644021093845,
-0.014966374263167381,
-0.014145269058644772,
0.01078881323337555,
-0.022186391055583954,
0.03324566408991814,
-0.0006645609973929822,
-0.009085552766919136,
-0.005069946404546499,
-0.016407843679189682,
-0.009459932334721088,
0.009075840935111046,
0.01370423287153244,
0.002271069446578622,
0.009426962584257126,
0.024227648973464966,
-0.013744760304689407,
-0.015153303742408752,
-0.01059128250926733,
-0.008975396864116192,
-0.03424827381968498,
-0.006207768339663744,
0.0016087498515844345,
0.006278545595705509,
0.011362046003341675,
0.0070447903126478195
] | [
0.5020349621772766,
-0.13781039416790009,
-0.0004480865318328142,
0.2589104175567627,
0.28555235266685486,
0.4098951816558838,
-0.2255546599626541,
0.4269223213195801,
-0.5917578935623169,
-0.10777964442968369,
-0.22639012336730957,
-0.047187160700559616,
0.25174957513809204,
0.5443605184555054,
-0.19650761783123016,
-0.08889537304639816,
0.7345038056373596,
0.8462774753570557,
-0.20491920411586761,
-0.6489795446395874,
-0.9450674057006836,
0.33079221844673157,
0.7207449674606323,
0.22253292798995972,
0.27906569838523865,
0.03742188215255737,
0.4647483825683594,
-0.42820319533348083,
-0.3664248287677765,
-0.3814413845539093,
0.38564494252204895,
0.19985473155975342,
-0.04873132333159447,
0.12942826747894287,
0.3611017167568207,
-0.343276709318161,
-0.43789437413215637,
-0.10431451350450516,
-0.04448627680540085,
-0.8819186091423035,
0.20040510594844818,
-0.16971619427204132,
0.3781285583972931,
0.7654841542243958,
-0.5629916787147522,
-0.5778133273124695,
-1.0799787044525146,
0.8068252205848694,
-0.3252459764480591,
0.1848055124282837,
-0.12097787857055664,
0.08082972466945648,
0.13689544796943665,
-0.023021699860692024,
-0.007606789469718933,
0.5718824863433838,
-0.7120959758758545,
0.26636695861816406,
0.16764162480831146,
-0.7523663640022278,
0.6556333303451538,
-0.04945167154073715,
0.13413064181804657,
-0.2652289569377899,
-0.10949774831533432,
0.2137371301651001,
0.4709702134132385,
0.0931566134095192,
-0.09617052972316742,
-0.6992823481559753,
0.17655739188194275,
-0.6442387104034424,
-0.6487036347389221,
0.3147937059402466,
-0.1851963996887207,
-0.026631152257323265,
-0.21564655005931854,
-0.037619005888700485,
0.3632355034351349,
-0.19178500771522522,
0.142141655087471,
-0.03856072202324867,
0.2509881854057312,
-0.38929903507232666,
0.05496063083410263,
-0.08943099528551102,
0.2906920909881592,
0.37516525387763977,
-0.0762302428483963,
0.2699083089828491,
-0.15502190589904785,
0.032602570950984955,
0.5408915281295776,
0.3683924674987793,
-0.2921207547187805,
0.26512637734413147,
0.6269450187683105,
-0.9125449657440186,
0.7042566537857056,
0.010599710047245026,
0.014073578640818596,
-0.3780600130558014,
-0.2209097295999527,
-0.0591718927025795,
-0.08260776102542877,
-0.016441326588392258,
-0.5144519805908203,
-0.40288105607032776,
-0.22058165073394775,
-0.24339745938777924,
0.1316184550523758,
0.09810882806777954,
-0.18225924670696259,
-0.2287377119064331,
-0.30842679738998413,
-0.4121333956718445,
0.285354882478714,
-0.3617049753665924,
-0.5335010290145874,
-0.03666875511407852,
0.23276804387569427,
1.0602437257766724,
-0.005277398973703384,
0.2683858871459961,
-0.0009967483347281814,
-0.024460243061184883,
0.4853687286376953,
0.47134706377983093,
-0.388225793838501,
0.42772260308265686,
0.33871716260910034,
0.5801052451133728,
-0.2293064445257187,
-0.31048816442489624,
-0.2199493944644928,
-0.3795890510082245,
0.22787021100521088,
0.004289311356842518,
0.629285991191864,
-0.6486244797706604,
-0.7025332450866699,
0.11030413210391998,
-0.2904370129108429,
0.048079635947942734,
-0.11568590253591537,
-0.40340158343315125,
-0.32793986797332764,
-0.32921913266181946,
-0.22205309569835663,
-0.31465932726860046,
-0.09717502444982529,
-0.11388003826141357,
-0.19980736076831818,
0.08217087388038635,
-0.5324381589889526,
0.3568401038646698,
0.545789361000061,
-0.33267930150032043,
0.5162296295166016,
0.5332727432250977,
0.3488665521144867,
-0.06958293169736862,
-0.030076751485466957,
-0.3176581561565399,
-0.4953674376010895,
0.29054784774780273,
0.33456701040267944,
0.5097289681434631,
-0.2637881636619568,
0.05127587914466858,
-0.3831624686717987,
0.5896430611610413,
0.32989317178726196,
-0.6399990916252136,
-0.4069477617740631,
-0.2087360918521881,
-0.05955914407968521,
0.4653697907924652,
0.05573926866054535,
0.3674688935279846,
-0.8108680844306946,
0.5460540056228638,
0.04176049679517746,
-0.21140697598457336,
0.05944669619202614,
0.30861395597457886,
-0.11183348298072815,
-0.06990620493888855,
-0.0760757327079773,
-0.17427748441696167,
-0.21771782636642456,
-0.20464389026165009,
-0.12707534432411194,
-0.5068769454956055,
0.9400510191917419,
-0.37435951828956604,
-0.2605223059654236,
0.8920263051986694,
0.3845285177230835,
-0.6976174712181091,
-0.607756495475769,
0.2577805519104004,
0.28607213497161865,
-0.20210979878902435,
-0.6524191498756409,
0.03319477289915085,
0.3227172791957855,
0.11250708252191544,
0.050397563725709915,
-0.10543406009674072,
0.8047696352005005,
-0.40560489892959595,
0.0991142988204956,
-0.7401836514472961,
0.08466831594705582,
0.3485601246356964,
-0.35650330781936646,
-0.019135672599077225,
-0.4730849862098694,
0.8529394268989563,
0.8662988543510437,
-0.2095380425453186,
0.1603616178035736,
0.5056164860725403,
0.1576310694217682,
0.45332226157188416,
0.3895755112171173,
-0.16527758538722992,
0.20831558108329773,
-0.20809049904346466,
0.07615816593170166,
0.17091524600982666,
0.216108500957489,
-0.5791841149330139,
0.025733714923262596,
0.11453761905431747,
0.055016230791807175,
-0.28951266407966614,
0.4841580092906952,
0.40164831280708313,
-0.2491523027420044,
0.1320495307445526,
-0.05020766705274582,
0.0350138358771801,
0.20639139413833618,
0.03667778521776199,
-0.5225437879562378,
-0.34312114119529724,
-0.17932236194610596,
-0.25859612226486206,
0.10371864587068558,
0.4361574649810791,
-0.10780812799930573,
-0.05637446790933609,
0.45086240768432617,
-0.12883105874061584,
0.32220569252967834,
0.06354717165231705,
0.2342027872800827,
-0.365458220243454,
-0.0077701350674033165,
0.36387500166893005,
0.028496133163571358,
0.3595982789993286,
-0.16417868435382843,
0.08101186156272888,
-0.56210857629776,
-0.3145350217819214,
0.4688500165939331,
0.4578373432159424,
0.4186572730541229,
-0.004159271251410246,
-0.6048713326454163,
0.42455559968948364,
0.45785120129585266,
-0.07268629968166351,
0.22143886983394623,
0.5594906806945801,
-0.7256476879119873,
-0.6716413497924805,
0.2900472581386566,
0.6062085032463074,
0.09298192709684372,
-0.8262268900871277,
-0.3139367997646332,
0.05435933172702789,
-0.44388970732688904,
-0.5540879964828491,
-0.19708102941513062,
-0.09738200157880783,
0.3282341957092285,
0.08752671629190445,
0.5781043767929077,
-0.24555113911628723,
0.30990639328956604,
0.27826523780822754,
-0.020904572680592537,
0.48432663083076477,
0.3304117023944855,
-0.1909702569246292,
-0.13141514360904694,
0.0210844948887825,
-0.5283004641532898,
-0.34157875180244446,
0.31794944405555725,
0.037935808300971985,
-0.21946020424365997,
-0.32646822929382324,
-6.010863304138184,
0.18581217527389526,
-0.7975369691848755,
0.16812267899513245,
-0.2179238498210907,
-0.15172363817691803,
0.6014852523803711,
-0.19145910441875458,
0.09770646691322327,
-0.4049113392829895,
-0.01575828157365322,
0.17069688439369202,
-0.0844087302684784,
-0.12117798626422882,
-0.36756035685539246,
0.7877105474472046,
0.598179817199707,
0.9364157319068909,
0.4861498773097992,
0.09169360250234604,
-0.4296410083770752,
-0.1854873150587082,
-0.3050578832626343,
0.6604692339897156,
0.6818870306015015,
-0.240659698843956,
-0.4335381090641022,
-0.6457385420799255,
-0.4492509365081787,
-0.1619037240743637,
-0.5280901789665222,
-0.21800345182418823,
0.7643985152244568,
-0.34330639243125916,
0.35894575715065,
-0.15619361400604248,
0.14565280079841614,
-0.46123477816581726,
0.027768729254603386,
-0.5880722403526306,
-0.18923881649971008,
0.4659392237663269,
0.39927563071250916,
-0.19000619649887085,
0.32925111055374146,
-0.5956311225891113,
-0.3057747781276703,
-0.13589569926261902,
-0.20681354403495789,
0.502206027507782,
0.26265910267829895,
-0.29742830991744995,
0.09332522004842758,
0.0834677591919899,
-0.12608100473880768,
0.03190315514802933,
-0.15191766619682312,
-0.015780417248606682,
-0.08540699630975723,
0.7020303010940552,
-0.03019053488969803,
0.08682715147733688,
0.05747028440237045,
-0.20786359906196594,
-0.4620230495929718,
0.2042846381664276,
-0.6001404523849487,
-1.035347580909729,
0.09940286725759506,
-0.33148226141929626,
-0.5342045426368713,
0.3911365568637848,
0.09372105449438095,
-0.5272765159606934,
-0.10167445242404938,
-1.006646752357483,
-0.01682787574827671,
0.5167914628982544,
-0.41127562522888184,
0.5781381130218506,
-0.17840591073036194,
-0.06136319413781166,
0.07499916851520538,
-0.08481355756521225,
-0.2244866043329239,
-0.4338972270488739,
-0.04037771746516228,
-0.18816976249217987,
-0.1538398712873459,
0.3093269169330597,
0.6017134189605713,
-0.45567670464515686,
0.519745945930481,
0.41935738921165466,
0.37446534633636475,
0.20950782299041748,
0.25101736187934875,
0.029886096715927124,
-0.3302077353000641,
-0.3852592408657074,
0.2074752151966095,
0.12838652729988098,
-0.47799375653266907,
-1.0801100730895996,
-0.221061572432518,
-0.06624186038970947,
-0.32045674324035645,
0.45102840662002563,
0.5333837866783142,
-0.5088449120521545,
-0.04479954391717911,
-0.09501335024833679,
-0.5818389058113098,
-0.05637860298156738,
0.4579911530017853,
-0.115279421210289,
0.1505509912967682,
0.14442558586597443,
0.4630497097969055,
-0.08119942992925644,
0.49315547943115234,
0.2454298883676529,
-0.1635688841342926,
-0.02613077498972416,
-0.011062851175665855,
-0.10396423190832138,
-0.16517776250839233,
-0.00789622962474823,
0.06221042573451996,
0.14972364902496338,
0.3823133409023285,
0.1468995362520218,
-0.18244990706443787,
-0.32689228653907776,
0.20454809069633484,
-0.3654705286026001,
0.04843642935156822,
-0.4113420844078064,
-0.033000849187374115,
-0.2051403671503067,
0.21491938829421997,
0.41510558128356934,
-0.02715905010700226,
0.3376094400882721,
0.20642304420471191,
0.11158439517021179,
-0.4716603755950928,
-0.01934479922056198,
-0.12552648782730103,
-0.08788833767175674,
-0.209028422832489,
-0.28801044821739197,
0.4184851348400116,
-0.10735315084457397,
-0.026691509410738945,
0.0074400692246854305,
0.4644506275653839,
-0.1543874442577362,
0.24929223954677582,
-0.2781880795955658,
0.7439972758293152,
0.03733231499791145,
-0.7765699625015259,
0.7434991002082825,
0.4721873104572296,
-0.11124242097139359,
-0.08077526837587357,
-0.3776204586029053,
-0.0873974934220314,
0.7534967064857483,
0.542443573474884,
0.004723129794001579,
0.06079959496855736,
-0.16446390748023987,
-0.1419205367565155,
0.13367091119289398,
-0.1517379879951477,
0.30351829528808594,
0.29826781153678894,
-0.11595414578914642,
0.03425009921193123,
-0.13016514480113983,
0.02161022089421749,
0.44718846678733826,
0.49730363488197327,
0.12659437954425812,
0.14320139586925507,
-0.35219427943229675,
-0.41191285848617554,
0.14538143575191498,
0.38934803009033203,
0.31772834062576294,
0.16857470571994781,
-0.11391492933034897,
0.5652908086776733,
-0.5970474481582642,
-0.05893663316965103,
0.34738650918006897,
-0.6459166407585144,
-0.16057418286800385,
0.4190467894077301,
0.10649678111076355,
-0.8110505938529968,
-0.12297290563583374,
0.18822723627090454,
0.15307588875293732,
-0.12073676288127899,
0.33642342686653137,
0.31319138407707214,
0.08625762164592743,
-0.23383046686649323,
-0.0786358043551445,
-0.293179452419281,
0.2572832703590393,
0.2111421376466751,
0.472592294216156,
-0.169130340218544,
-0.48005586862564087,
-0.322259783744812,
0.038976430892944336,
0.14453358948230743,
-0.3912648558616638,
-0.27107003331184387,
-0.635699450969696,
-0.19568057358264923,
0.4256073236465454,
-0.02570747770369053,
-0.6669281125068665,
-0.6396085023880005,
-0.07006771862506866,
-0.5116825699806213,
-0.5658969283103943,
0.1545097827911377,
-0.021738477051258087,
0.09023120999336243,
0.49163174629211426,
0.12592384219169617,
0.227985680103302,
0.04426013305783272,
-0.006499796640127897,
-0.5181517004966736,
0.1705082207918167,
0.25750499963760376,
-0.5782600045204163,
-0.18506747484207153,
0.4021061062812805,
-0.08037357032299042,
-0.18145869672298431,
-0.634700357913971,
0.44700223207473755,
0.0661209225654602,
-0.22219377756118774,
-0.05554523319005966,
-0.5813108682632446,
0.07014241069555283,
0.1327759027481079,
-0.3610028624534607,
-0.36434072256088257,
-0.3520706295967102,
0.2800925672054291,
0.18691718578338623,
-0.5943937301635742,
-0.15311363339424133,
-0.42390868067741394,
0.3169649839401245,
0.07977063208818436,
-0.2441030740737915,
-0.6754740476608276,
0.23342423141002655,
-0.4901781976222992,
-0.0002595725527498871,
0.26978182792663574,
0.40356048941612244,
-0.0062888916581869125,
0.035377807915210724,
0.49671563506126404,
-0.1902078539133072,
0.009524988010525703,
-0.549045979976654,
-0.09809570014476776,
-0.04650907218456268,
0.2711580991744995,
0.16126462817192078,
0.06748823076486588,
0.6230109930038452,
-0.33775532245635986,
-0.3157852590084076,
0.28335198760032654,
0.10265547037124634,
-0.5180365443229675,
-0.41064193844795227,
0.1559058278799057,
-0.1288428157567978,
0.10988999158143997,
-0.39010101556777954,
0.07026197761297226,
1.20620858669281,
0.2601682245731354,
-0.6045639514923096,
-0.07635308802127838,
-0.07768523693084717,
0.5661548972129822,
-0.10296392440795898,
-0.47557541728019714,
-0.08437655121088028,
0.5774999856948853,
-0.013182689435780048,
0.19854797422885895,
-0.21724310517311096,
0.001590595580637455,
0.6808297038078308,
-0.4242459535598755,
0.28083592653274536,
0.24836011230945587,
-0.11855223774909973,
-0.09856629371643066,
0.22043173015117645,
-0.02836732380092144,
0.27266380190849304,
0.1870768517255783,
0.2641233205795288,
0.19806165993213654,
0.29842430353164673,
-0.18749883770942688,
0.19158652424812317,
0.05806325376033783,
0.09321168810129166,
-0.14770162105560303,
0.4274848997592926,
0.6239338517189026,
0.09663902968168259,
0.47514277696609497,
-0.4773196578025818,
-0.3276671767234802,
0.32953548431396484,
-0.0052515617571771145,
0.1578734666109085,
-0.21580949425697327,
-0.16606447100639343,
0.5273323059082031,
0.6889960765838623,
-0.06965301185846329,
-0.25435546040534973,
-0.20784807205200195,
0.09330246597528458,
0.3426782190799713,
0.18564356863498688,
-0.08139142394065857,
-0.3573003113269806,
0.5242325663566589,
0.5530375838279724,
-0.30511701107025146,
-0.31051158905029297,
0.513464093208313,
-0.21058230102062225,
-0.373478502035141,
0.29454025626182556,
0.11180117726325989,
0.4769103229045868,
0.29435446858406067,
0.5711489319801331,
0.4488719701766968,
0.0027367572765797377,
-0.12944261729717255,
0.392128586769104,
-0.39324551820755005,
0.4294537901878357,
-0.2300058901309967,
0.12616363167762756,
-0.35876867175102234,
-0.060316301882267,
0.15466798841953278,
-0.30714184045791626,
0.5567178130149841,
0.3037797510623932,
-0.13766086101531982,
-0.2696731686592102,
0.0003355726657900959,
-0.32068347930908203,
0.7537623643875122,
0.01101140771061182,
0.005726939998567104,
-0.13218823075294495,
0.10292088240385056,
-0.4175868630409241,
0.10522458702325821,
-0.42226967215538025,
-0.03458872064948082,
-0.29156723618507385,
-0.5311569571495056,
-0.03850176930427551,
-0.5370322465896606,
-0.30645641684532166,
0.944606602191925,
0.1898052990436554,
-0.20982438325881958,
-0.5484418869018555,
0.5604074001312256,
0.003266297746449709,
0.13998469710350037,
0.1598910391330719,
0.03243136405944824,
0.4205857515335083,
0.20899294316768646,
0.025268303230404854,
0.04552619159221649,
-1.0571538209915161,
-0.22962090373039246,
-0.8441234827041626,
-0.13407376408576965,
0.3545888364315033,
0.10079090297222137,
-0.02024625428020954,
0.16042405366897583,
0.2642945349216461,
0.47248759865760803,
0.5082870125770569,
-0.08485294133424759,
-0.0873679667711258,
-0.5017358064651489,
0.06832728534936905,
-0.12856590747833252,
0.2962271273136139,
-0.3934118449687958,
0.2388283759355545,
-0.0863148644566536,
0.0824103131890297,
0.3029596507549286,
-0.6528711318969727,
0.6402125358581543,
-0.13395732641220093,
-0.008016262203454971,
-0.15057814121246338,
0.6686297655105591,
-0.633000910282135,
-0.34209710359573364,
0.05047869309782982,
-0.02505495212972164,
0.059229448437690735,
-0.41683754324913025,
0.07938361912965775,
0.17945417761802673,
-0.18753157556056976,
0.1517043560743332,
0.43611523509025574,
0.020220980048179626,
-0.45309144258499146,
-0.07093643397092819,
-0.7542700171470642,
0.6838836073875427,
-0.20259644091129303,
-0.33501291275024414,
0.4798770248889923,
0.20339994132518768,
0.11387421190738678,
-0.1928684264421463,
-0.02088504284620285,
-0.15487602353096008,
0.5788798332214355,
-0.47586047649383545
] |
BACKGROUND The purpose of this study was to explore the function and mechanism of peroxisome proliferator activated receptor agonist (PPARγ) in the toll-like receptor 2 (TLR2)/nod-like receptor with pyrin domain containing 3 (NLRP3) inflammatory corpuscle pathway of asthmatic mice. MATERIAL AND METHODS Eighteen female mice (C57) were randomly divided into 4 groups: the control group, the asthma model group challenged by ovalbumin (OVA), the rosiglitazone group, and the PPARγ agonist rosiglitazone treatment group. The infiltration of peribronchial inflammatory cells as well as the proliferation and mucus secretion of bronchial epithelial goblet cells were observed by hematoxylin and eosin and periodic acid-Schiff staining. Western blots were employed to detect the expression levels of TLR2, PPARγ, nuclear factor-kappa B (NF-kappaB), NLRP3, and ASC [apoptosis-associated speck-like protein containing C-terminal caspase recruitment domain [CARD]). RESULTS The number of inflammatory cells and eosinophils, and the levels of OVAs IgE, interleukin-4 (IL-4), and IL-13 were significantly higher in the C57 asthma group compared to the C57 control group and the treatment group (P<0.05). The infiltration of peribronchiolar inflammatory cells, wall thickening, goblet cell hyperplasia, and mucus secretion in the treatment group were all significantly decreased compared to those in the asthma group. PPARg expression in the treatment group was significantly higher compared to the asthma group and the control group (P<0.05). The protein expression levels of TLR2, NF-kappaB, NLRP3, and ASC were significantly lower compared to the asthma group but were higher compared to the control group (P<0.05). CONCLUSIONS PPARγ rosiglitazone ameliorates airway inflammation by inhibiting NF-kappaB expression in asthmatic mice, and further inhibits the activation of TLR2/NLRP3 inflammatory corpuscles. | [
-0.010111180134117603,
0.01595953293144703,
-0.009267101064324379,
0.01196148619055748,
0.0043852198868989944,
0.007279799319803715,
0.008514570072293282,
0.007170205935835838,
-0.00798448733985424,
-0.004579063039273024,
-0.013042778708040714,
0.004839537665247917,
-0.009471760131418705,
0.015795303508639336,
-0.0018751302268356085,
0.011535273864865303,
-0.015162322670221329,
0.005059098359197378,
0.0067911576479673386,
-0.00754180084913969,
-0.0003579638432711363,
0.007101915776729584,
0.00994204729795456,
0.023886388167738914,
0.022634148597717285,
0.005232473369687796,
0.014781596139073372,
-0.02757466956973076,
-0.031224848702549934,
-0.007731449790298939,
-0.0000868684146553278,
-0.012090728618204594,
-0.014993374235928059,
0.021209709346294403,
0.008825493976473808,
-0.010616736486554146,
-0.0008082800195552409,
0.012651276774704456,
0.005250619258731604,
-0.004183492157608271,
-0.011600907891988754,
-0.0017897472716867924,
0.005689564626663923,
-0.0019452933920547366,
-0.009766816161572933,
-0.002449600026011467,
-0.0006138147437013686,
0.01967211626470089,
-0.028056439012289047,
0.00229612085968256,
-0.001197506207972765,
0.015231456607580185,
-0.01658119447529316,
0.029045073315501213,
-0.0057808393612504005,
-0.003258184529840946,
0.01766689494252205,
0.008038119412958622,
0.002243154216557741,
-0.0022783216554671526,
0.020581688731908798,
-0.016129031777381897,
0.005708304233849049,
-0.0008087554015219212,
-0.0004942383384332061,
-0.0667366087436676,
0.031620487570762634,
-0.0054942527785897255,
-0.005284816026687622,
0.0010064542293548584,
-0.0070734466426074505,
0.0016271168133243918,
-0.023795170709490776,
0.009268650785088539,
-0.03210137411952019,
-0.029226811602711678,
0.007806937210261822,
-0.003913113847374916,
0.01429180707782507,
-0.020254606381058693,
-0.007592679932713509,
-0.006388307083398104,
-0.003508912166580558,
0.0028268806636333466,
-0.003839000826701522,
0.018503114581108093,
-0.030992336571216583,
0.0037297005765140057,
-0.005694280378520489,
0.018227407708764076,
-0.0039170957170426846,
0.007662124000489712,
-0.03225842863321304,
-0.007585449144244194,
-0.0352555476129055,
0.020580003038048744,
-0.02492458000779152,
0.0022152538876980543,
0.009070812724530697,
-0.02102223038673401,
-0.02129790373146534,
-0.0018053390085697174,
0.018750540912151337,
-0.003875815076753497,
-0.023837745189666748,
0.010895814746618271,
0.020857691764831543,
0.002236500382423401,
0.02271684631705284,
0.013530961237847805,
-0.012297620065510273,
-0.006505729630589485,
-0.011899619363248348,
0.004265724681317806,
-0.01009343471378088,
0.002721012569963932,
0.006373723968863487,
0.01949353516101837,
0.00889958068728447,
-0.017099065706133842,
0.018296919763088226,
-0.014586682431399822,
-0.008760353550314903,
0.023646006360650063,
-0.0008273434359580278,
-0.0004326626658439636,
0.03698645532131195,
0.006619052961468697,
0.01305537112057209,
0.007814032956957817,
-0.008259635418653488,
-0.002306621056050062,
0.02618052251636982,
0.004148455802351236,
0.019695524126291275,
0.005925752222537994,
-0.01326308585703373,
-0.009756239131093025,
-0.013374494388699532,
-0.018185816705226898,
0.008087486028671265,
0.011091931723058224,
0.011430315673351288,
0.011357701383531094,
0.024379393085837364,
0.009441574104130268,
0.005591088905930519,
0.011951792053878307,
0.019122006371617317,
-0.00040843826718628407,
0.012416665442287922,
-0.0030967332422733307,
-0.009088221937417984,
-0.02647218480706215,
0.0024655447341501713,
-0.0054895151406526566,
-0.0201515331864357,
-0.015140855684876442,
-0.0016469347756356,
0.0029663750901818275,
-0.032851580530405045,
-0.00960836187005043,
0.00869013648480177,
0.010326043702661991,
-0.013173106126487255,
0.008660116232931614,
-0.019508637487888336,
-0.016336116939783096,
-0.0005446248687803745,
0.004528372082859278,
0.010684527456760406,
-0.050382114946842194,
-0.009998299181461334,
0.006372886244207621,
0.003028404898941517,
-0.012982047162950039,
-0.016498805955052376,
0.006034534424543381,
-0.025735218077898026,
0.06599776446819305,
-0.008531976491212845,
0.0009025819599628448,
0.03842700272798538,
-0.024026405066251755,
-0.011066212318837643,
-0.02914709970355034,
-0.009268732741475105,
-0.0017179466085508466,
-0.018875587731599808,
-0.02060849219560623,
0.01438199169933796,
0.0034404387697577477,
-0.015691956505179405,
0.015664776787161827,
-0.013871675357222557,
0.002173862187191844,
-0.004226715303957462,
0.012474369257688522,
-0.00047720037400722504,
0.00322141544893384,
0.0009860754944384098,
-0.0070224665105342865,
0.020575905218720436,
-0.01179724745452404,
0.020726235583424568,
0.00026156811509281397,
-0.007223653141409159,
-0.01954135298728943,
0.00004374515265226364,
0.010825526900589466,
0.020331058651208878,
-0.00937001034617424,
0.008534207940101624,
-0.007236446253955364,
0.01480508130043745,
0.012881237082183361,
-0.016518257558345795,
-0.0022846334613859653,
-0.012745305895805359,
-0.014585671946406364,
-0.005952042527496815,
0.021630115807056427,
0.002557731233537197,
0.0008211489766836166,
0.013123220764100552,
0.01212505716830492,
0.004511588718742132,
0.011853961274027824,
-0.005442291963845491,
-0.012178672477602959,
0.0018241239013150334,
-0.007827036082744598,
-0.010811978951096535,
-0.009095510467886925,
0.0226084366440773,
-0.020610246807336807,
0.015263701789081097,
-0.004219939932227135,
0.008947281166911125,
-0.012650391086935997,
-0.008977380581200123,
-0.008152429014444351,
0.009059414267539978,
-0.012141728773713112,
0.014174886047840118,
0.01758173480629921,
0.041981641203165054,
0.01713741011917591,
0.014212530106306076,
-0.020999563857913017,
0.005387633107602596,
0.004687623120844364,
0.021407194435596466,
0.005770567804574966,
0.01578623615205288,
-0.010060361586511135,
-0.020326031371951103,
-0.006884788628667593,
0.023672496899962425,
0.013680445961654186,
-0.00360015407204628,
0.0030764394905418158,
0.0072260284796357155,
-0.002175509463995695,
-0.022682175040245056,
0.00015363539569079876,
-0.008750876411795616,
0.006670142523944378,
0.011269507929682732,
-0.0011293329298496246,
0.008699027821421623,
-0.0028889526147395372,
-0.0014049201272428036,
-0.0811438262462616,
-0.0024372662883251905,
-0.01619572564959526,
0.022189639508724213,
-0.00012008874909952283,
0.0024261141661554575,
0.007126255892217159,
0.014578165486454964,
-0.0010547204874455929,
0.0071657570078969,
-0.012398142367601395,
-0.01188060361891985,
-0.00550175691023469,
0.004469262436032295,
0.0013194684870541096,
-0.005414612125605345,
0.011286149732768536,
-0.01775038056075573,
-0.005179754924029112,
-0.03093343786895275,
0.02208075299859047,
-0.0016168073052540421,
0.0032068882137537003,
-0.006759895943105221,
-0.0048693884164094925,
-0.02528969570994377,
0.003308839164674282,
-0.0025631077587604523,
-0.006621830631047487,
-0.0013877077726647258,
-0.015514806844294071,
-0.011246733367443085,
0.03744427114725113,
-0.0036225556395947933,
0.034537672996520996,
0.0036181649193167686,
-0.010522657074034214,
-0.010984662920236588,
-0.014033093117177486,
0.02820489928126335,
-0.008542757481336594,
0.0160971712321043,
0.00926908291876316,
-0.0012045572511851788,
-0.017346423119306564,
-0.0032822955399751663,
0.0182089451700449,
-0.008178230375051498,
0.02258111722767353,
0.003551769768819213,
0.0011677572038024664,
-0.018351830542087555,
0.002228309866040945,
0.009353953413665295,
-0.008174033835530281,
0.014760533347725868,
-0.020825576037168503,
-0.010000481270253658,
-0.00799563154578209,
-0.0057507166638970375,
-0.019306041300296783,
-0.02532561495900154,
0.02057945355772972,
0.013456659391522408,
-0.0031200512312352657,
-0.006312365178018808,
0.0056328605860471725,
-0.010967591777443886,
0.00020853569731116295,
-0.005622785538434982,
-0.007279247976839542,
0.006610390264540911,
-0.026714088395237923,
-0.006127623841166496,
0.024954047054052353,
-0.00649670697748661,
-0.016768410801887512,
-0.00005068647442385554,
-0.001963577698916197,
0.011016816832125187,
-0.022136934101581573,
-0.014278629794716835,
-0.03459453582763672,
-0.0027604438364505768,
-0.03251156955957413,
-0.0011878586374223232,
0.01269099023193121,
0.02237727865576744,
0.010209871456027031,
-0.011173605918884277,
0.012917470186948776,
0.020144304260611534,
0.005544126965105534,
0.011173583567142487,
0.01067187450826168,
-0.0028023701161146164,
-0.005147110670804977,
0.007437321823090315,
0.0033225747756659985,
0.00727452989667654,
-0.01999533921480179,
0.007908681407570839,
-0.002980415243655443,
-0.007069072686135769,
-0.0009996597655117512,
0.01348341628909111,
-0.003798941383138299,
0.007830167189240456,
-0.014841290190815926,
-0.002620361279696226,
-0.035751111805438995,
-0.007334023714065552,
-0.000672927766572684,
0.031264565885066986,
0.006807154044508934,
-0.006386980414390564,
-0.0319206565618515,
0.00469871936365962,
0.07276611030101776,
-0.018796198070049286,
0.00809335894882679,
-0.012979095801711082,
0.02118596062064171,
-0.026448052376508713,
-0.007327135652303696,
0.002618713304400444,
0.02117617428302765,
0.043484240770339966,
0.011026465333998203,
-0.03138338401913643,
-0.018593182787299156,
-0.03092249482870102,
-0.01656331494450569,
0.009342576377093792,
-0.01378635037690401,
-0.0087805837392807,
0.014417273923754692,
0.013723267242312431,
0.0005202731117606163,
-0.030099695548415184,
0.008233734406530857,
0.020331155508756638,
-0.0038471808657050133,
-0.021229971200227737,
-0.021697361022233963,
-0.012593627907335758,
-0.00727404560893774,
0.009820482693612576,
-0.010417738929390907,
-0.003862271551042795,
-0.00897216610610485,
-0.0005954857915639877,
0.009228329174220562,
0.015768026933073997,
0.014237094670534134,
0.004387774504721165,
0.003237496130168438,
0.0023745931684970856,
-0.014955191873013973,
-0.01384778507053852,
0.022900696843862534,
0.005821952596306801,
-0.003944362513720989,
-0.0024737739004194736,
0.011153111234307289,
-0.005973062012344599,
-0.0012846739264205098,
0.007338014896959066,
-0.013292403891682625,
0.0030959383584558964,
0.017642343416810036,
0.01998729445040226,
0.011159392073750496,
-0.020575152710080147,
0.006040050648152828,
-0.005371995735913515,
0.0032266308553516865,
-0.014537932351231575,
-0.0165045615285635,
0.017525287345051765,
-0.0075820330530405045,
0.004073473159223795,
0.005860704928636551,
-0.018890950828790665,
-0.022340714931488037,
-0.0029117607045918703,
-0.015495514497160912,
0.005866414401680231,
0.016126303002238274,
0.004628098104149103,
-0.002330985153093934,
-0.02656264416873455,
-0.017265206202864647,
0.008743980899453163,
0.03662997856736183,
0.006939871236681938,
-0.0006404640153050423,
-0.005237769801169634,
-0.01759498566389084,
0.020520014688372612,
0.0320650190114975,
0.008315317332744598,
0.024313606321811676,
-0.017913836985826492,
-0.015769679099321365,
-0.07499071210622787,
-0.017767025157809258,
-0.013315968215465546,
-0.004492918029427528,
0.013510488905012608,
0.043800484389066696,
-0.01614789478480816,
-0.020747819915413857,
-0.006479277275502682,
-0.001050161779858172,
0.021250814199447632,
0.011696292087435722,
0.013114359229803085,
-0.012708928436040878,
0.011339868418872356,
0.002841903828084469,
0.003932399209588766,
-0.010475349612534046,
-0.017132967710494995,
0.0234889667481184,
0.013346882537007332,
-0.010800397023558617,
-0.01581389084458351,
-0.0004998121876269579,
-0.003938134294003248,
-0.0815504938364029,
-0.014916585758328438,
0.011946023441851139,
0.012716473080217838,
0.01744670979678631,
-0.013434031046926975,
0.013257603161036968,
-0.026074504479765892,
-0.0028694751672446728,
-0.014968683011829853,
-0.008744479157030582,
-0.00328453304246068,
-0.00747929560020566,
-0.006984098814427853,
0.0015611345879733562,
0.00020925476565025747,
0.021919410675764084,
0.02660202607512474,
-0.015610973350703716,
-0.003224432934075594,
0.0011991924839094281,
0.012880351394414902,
-0.009659862145781517,
0.002247113035991788,
-0.004165858030319214,
0.00197294051758945,
0.006900749169290066,
0.01872103102505207,
0.014178289100527763,
-0.019204294309020042,
-0.0002651996910572052,
-0.011143418960273266,
-0.021502243354916573,
-0.01351085864007473,
-0.020076710730791092,
-0.018604271113872528,
0.00692363828420639,
-0.01260414533317089,
-0.01602134481072426,
-0.003291994333267212,
0.0007252038922160864,
0.008609904907643795,
-0.012954655103385448,
0.009378472343087196,
-0.02189929410815239,
-0.005783682223409414,
0.007553909905254841,
-0.009904693812131882,
0.017699921503663063,
0.004565403331071138,
0.015105108730494976,
-0.020748978480696678,
0.005379979964345694,
0.010924059897661209,
0.011878065764904022,
-0.004864051006734371,
0.0028757615946233273,
0.00020824233070015907,
-0.0003832231741398573,
0.010318433865904808,
0.006005842238664627,
0.010333348996937275,
-0.013089952990412712,
0.07133475691080093,
0.0017883866094052792,
0.010816019028425217,
-0.005501925945281982,
0.02071976289153099,
0.006236919201910496,
-0.01653692126274109,
-0.0024697398766875267,
-0.018776189535856247,
-0.0225203987210989,
0.0019492158899083734,
-0.009074006229639053,
-0.0003979932516813278,
0.012859044596552849,
0.0028732693754136562,
-0.022868743166327477,
0.011929456144571304,
0.003975424449890852,
-0.0052126748487353325,
0.005192291457206011,
-0.015274127945303917,
0.012544146738946438,
-0.008973007090389729,
-0.017874885350465775,
0.03320486471056938,
0.0017665042541921139,
-0.015268364921212196,
-0.01224273256957531,
-0.01138672512024641,
0.012880084104835987,
-0.0015127239748835564,
-0.019962012767791748,
0.002213273663073778,
0.016515931114554405,
0.015879271551966667,
0.023493977263569832,
0.01971283182501793,
0.009220846928656101,
-0.004223587457090616,
-0.0013876636512577534,
-0.007838809862732887,
0.005424949806183577,
-0.0012869898928329349,
0.0037272938061505556,
0.023602860048413277,
-0.016147848218679428,
-0.01099136471748352,
-0.019054118543863297,
0.011660465970635414,
0.005556035786867142,
-0.005267285276204348,
0.007051881402730942,
0.022000938653945923,
-0.029653411358594894,
-0.011968245729804039,
0.030101515352725983,
0.010299949906766415,
0.01770484633743763,
-0.012205970473587513,
-0.007352778222411871,
-0.008573738858103752,
-0.005776698235422373,
0.032160136848688126,
-0.025250069797039032,
0.014734940603375435,
0.0072485008276999,
0.0018049499485641718,
-0.016541816294193268,
-0.009502127766609192,
0.01627166010439396,
-0.008791415020823479,
0.014406230300664902,
0.007235337980091572,
0.005330359563231468,
0.027585919946432114,
0.014207383617758751,
0.004272024147212505,
0.0073761241510510445,
0.01446373388171196,
0.0033722389489412308,
-0.02095887064933777,
-0.0022803563624620438,
-0.005199163220822811,
-0.0007977191125974059,
0.006820175796747208,
0.024426545947790146,
0.018903279677033424,
-0.011678903363645077,
-0.0009000428253784776,
0.0069718994200229645,
-0.006616099737584591,
0.0070348442532122135,
0.008277147077023983,
0.01127677969634533,
0.0008928403258323669,
0.03299601376056671,
0.024427371099591255,
0.006613381206989288,
-0.020235570147633553,
0.012819750234484673,
-0.011151731014251709,
0.0008693109266459942,
-0.0012247153790667653,
-0.002734316512942314,
-0.004529732279479504,
0.0041898866184055805,
-0.005361511372029781,
0.004159307107329369,
-0.01904952898621559,
0.018080338835716248,
-0.01190200075507164,
0.005358484573662281,
0.05268048122525215,
0.01414014957845211,
0.017811214551329613,
0.029443318024277687,
-0.010605324991047382,
-0.016103647649288177,
0.019990622997283936,
-0.015064315870404243,
0.01591009460389614,
-0.01779365725815296,
-0.05705590546131134,
-0.0016080697532743216,
0.011150730773806572,
-0.004071580246090889,
-0.011454008519649506,
0.03522691875696182,
0.01814875565469265,
-0.024291161447763443,
0.0231841541826725,
0.012825997546315193,
-0.008961119689047337,
-0.029408451169729233,
-0.006764002609997988,
0.006466682069003582,
-0.0217728354036808,
-0.015368232503533363,
-0.003368186531588435,
-0.03557629510760307,
-0.024916131049394608,
-0.01371834333986044,
0.0021167516242712736,
-0.009610868990421295,
0.007642348296940327,
-0.01898130401968956,
0.024060998111963272,
0.023682940751314163,
0.00984523817896843,
0.028436169028282166,
0.015308232046663761,
0.01220987644046545,
-0.015637829899787903,
-0.005847299471497536,
0.010196654126048088,
0.010455679148435593,
0.009420678950846195,
-0.020524710416793823,
-0.016922900453209877,
-0.027532747015357018,
-0.004717904143035412,
0.018890565261244774,
0.010278074070811272,
-0.017579559236764908,
0.004242612048983574,
-0.029013000428676605,
-0.023598283529281616,
0.001615370623767376,
0.010502517223358154,
-0.009631253778934479,
0.02333737164735794,
-0.02694760262966156,
-0.0025810925289988518,
0.011129586026072502,
-0.015135117806494236,
-0.010207083076238632,
-0.03147689253091812,
-0.0025364302564412355,
0.0291181318461895,
0.01823185570538044,
0.013310274109244347,
-0.037493374198675156,
-0.0027638785541057587,
-0.014692600816488266,
-0.002391890389844775,
-0.01865607127547264,
-0.014719539321959019,
0.005733633879572153,
0.00036259135231375694,
0.018602121621370316,
-0.01959829032421112,
-0.007951880805194378,
-0.012851642444729805,
0.016101662069559097,
-0.028637856245040894,
-0.0010920101776719093,
-0.013964001089334488,
-0.04385528340935707,
-0.004118621349334717,
0.00399604020640254,
0.010441751219332218,
-0.004483163356781006
] | [
0.04434388875961304,
-0.02363533526659012,
-0.08289844542741776,
0.06702444702386856,
0.08037400245666504,
0.7225525975227356,
0.13854943215847015,
-0.6640746593475342,
-0.1317034512758255,
-0.14140450954437256,
0.3597981631755829,
0.47484782338142395,
0.17787230014801025,
-0.04167604818940163,
-0.13975919783115387,
0.8855195641517639,
0.5496627688407898,
0.09725039452314377,
-0.1927037388086319,
-0.8034157156944275,
0.018624506890773773,
-0.327987939119339,
0.30099937319755554,
-0.08192655444145203,
0.063836470246315,
0.18899089097976685,
0.3100886046886444,
-0.0014344565570354462,
0.456915020942688,
-0.05967103689908981,
-0.46281957626342773,
0.7933210134506226,
0.014399520121514797,
-0.14579367637634277,
0.1241612657904625,
0.030451074242591858,
0.19335512816905975,
0.194252148270607,
0.2607613801956177,
-0.0525740310549736,
-0.4006768763065338,
-0.15836508572101593,
-0.19342970848083496,
0.698613703250885,
-0.24670343101024628,
-0.14508214592933655,
-1.0576655864715576,
0.5280469655990601,
0.09684783965349197,
0.04050292819738388,
0.4927642345428467,
0.23237349092960358,
0.5167826414108276,
0.24772684276103973,
0.003591095795854926,
-0.1287875473499298,
-0.2571762502193451,
-0.44565850496292114,
0.07311012595891953,
-0.4376160800457001,
0.0010353827383369207,
0.6662300825119019,
0.09870728105306625,
0.08544676005840302,
0.0365682877600193,
0.7742284536361694,
0.23526985943317413,
0.043555933982133865,
-0.16707192361354828,
0.028438743203878403,
-0.07997775077819824,
0.12200883775949478,
-0.3688494563102722,
0.25896620750427246,
-0.22412772476673126,
0.06100493669509888,
0.21619625389575958,
-0.21961133182048798,
0.45040997862815857,
0.14983642101287842,
0.43819567561149597,
-0.1092192530632019,
0.41960930824279785,
-0.31089991331100464,
0.4610418379306793,
0.26934853196144104,
0.12219647318124771,
-0.10248764604330063,
-0.5099112391471863,
-0.28304094076156616,
-0.41150227189064026,
-0.45867758989334106,
0.39799588918685913,
0.6356956958770752,
0.0014408924616873264,
0.5552159547805786,
0.03919832408428192,
0.02740934118628502,
0.12473076581954956,
0.05376328155398369,
-0.24787504971027374,
0.420133113861084,
-0.19638173282146454,
-0.1925613433122635,
-0.7697610259056091,
0.02310366742312908,
0.15273429453372955,
-0.6442403793334961,
-1.1673673391342163,
0.06606508791446686,
-0.8977636098861694,
-0.040183860808610916,
-0.22444963455200195,
-0.39514508843421936,
-0.05940365046262741,
0.21462717652320862,
-0.11693534255027771,
0.012112733907997608,
-0.021316824480891228,
0.5205211043357849,
-0.6085861921310425,
0.9362444877624512,
-0.40837767720222473,
0.43381398916244507,
-0.03755181282758713,
0.05005260556936264,
0.3940635323524475,
-0.12766684591770172,
-0.0341285802423954,
0.6623895764350891,
0.37996232509613037,
0.45316630601882935,
-0.39434853196144104,
0.5164850950241089,
-0.19130080938339233,
-0.24415475130081177,
0.3597841262817383,
0.6625834703445435,
0.07169537246227264,
0.1361529678106308,
-0.6052613854408264,
-0.3450486958026886,
-0.5101683139801025,
0.16835835576057434,
0.224776029586792,
-0.6480342745780945,
-0.005442661698907614,
0.06605862826108932,
-0.3017573654651642,
-0.1522170603275299,
0.09091232717037201,
-0.28185755014419556,
-0.2172481119632721,
-0.26821470260620117,
-0.41410791873931885,
0.33041128516197205,
-0.4009591042995453,
-0.44367796182632446,
-0.0654870942234993,
-0.008166546002030373,
0.2698226869106293,
0.25316768884658813,
-0.22519591450691223,
0.48330754041671753,
0.7702834606170654,
0.05211985483765602,
0.3723808228969574,
-0.015474485233426094,
-0.07315871119499207,
0.29754403233528137,
-0.5675914883613586,
-0.23200611770153046,
-0.30531513690948486,
-0.7518262267112732,
-0.0577034130692482,
0.1475268453359604,
0.5134377479553223,
0.02042371779680252,
0.114714115858078,
-0.07686697691679001,
-0.4768868684768677,
-0.4161321818828583,
-0.31628358364105225,
-0.6946332454681396,
0.31618696451187134,
0.08101055026054382,
0.45582398772239685,
0.22066736221313477,
0.2955115735530853,
0.25091734528541565,
-0.08647073060274124,
-0.1761784851551056,
0.9233278036117554,
-0.42812836170196533,
1.8709582090377808,
-0.44658562541007996,
-0.12024485319852829,
1.028862714767456,
0.5551909804344177,
0.152923122048378,
0.11565601080656052,
-0.23718701303005219,
0.7362861633300781,
-0.17189903557300568,
-0.4706052541732788,
-0.02726803719997406,
-0.165250763297081,
-0.2786395847797394,
0.08872741460800171,
0.20825456082820892,
0.05964554846286774,
0.28955939412117004,
-0.41626906394958496,
-0.0830199345946312,
0.16686059534549713,
-0.22447602450847626,
0.16779106855392456,
0.2685617506504059,
0.1323603242635727,
-0.17042779922485352,
0.17162451148033142,
-0.6612474918365479,
0.5631294846534729,
0.4492356777191162,
-0.19083267450332642,
0.8064435720443726,
0.48737257719039917,
0.05491717532277107,
0.6551483869552612,
-0.38008320331573486,
0.20930077135562897,
-0.07009250670671463,
0.31718313694000244,
-0.2529338598251343,
-0.03327399492263794,
0.12370505183935165,
-0.2279231995344162,
-0.06630485504865646,
-0.06616976857185364,
-0.13903212547302246,
-0.03599393740296364,
0.8197547793388367,
-0.5666460394859314,
-0.32520511746406555,
0.04546307027339935,
-0.17260639369487762,
-0.08754363656044006,
0.5518839955329895,
-0.8473344445228577,
-0.06966251134872437,
0.0034408969804644585,
0.235982283949852,
-0.004266937263309956,
-0.4635787904262543,
-0.15713034570217133,
0.24276292324066162,
-0.2013917714357376,
-0.8271211385726929,
0.05046156793832779,
-0.4942263662815094,
-0.051020827144384384,
0.3668440580368042,
0.36128363013267517,
0.5278325080871582,
0.5765482187271118,
-0.7020406126976013,
-0.5007125735282898,
-0.654994547367096,
1.053932547569275,
0.4147668778896332,
1.0369420051574707,
-0.0029528518207371235,
-0.45178699493408203,
0.13261017203330994,
-0.06681640446186066,
-0.7073297500610352,
-0.10827363282442093,
0.5794075131416321,
-0.3684579133987427,
-0.9027533531188965,
0.14705152809619904,
-0.05463317781686783,
0.934709370136261,
-0.13303588330745697,
0.015984995290637016,
-0.2119426131248474,
-0.4268580675125122,
-0.17514163255691528,
-0.04320434480905533,
-0.25356602668762207,
0.2255266308784485,
0.47993203997612,
-0.20246627926826477,
-0.11072815954685211,
0.3319048285484314,
0.5575437545776367,
-0.258723646402359,
0.9405651688575745,
0.824737548828125,
0.15923340618610382,
-0.1345415860414505,
0.22228768467903137,
-0.43453797698020935,
-0.1764528900384903,
-0.2961201071739197,
-0.07611513882875443,
-0.4976250231266022,
0.2684656083583832,
-5.801211833953857,
0.2810184359550476,
-0.2249363511800766,
-0.10351927578449249,
-0.008086838759481907,
0.2107703536748886,
1.0963129997253418,
-0.008337168954312801,
0.07556328922510147,
0.10235755145549774,
0.08664346486330032,
0.5928782820701599,
0.11266923695802689,
0.18243259191513062,
-0.060035765171051025,
0.3002440333366394,
0.0192393958568573,
-0.24735938012599945,
0.664414644241333,
0.13400711119174957,
0.0473005548119545,
-0.17841844260692596,
-0.2609873116016388,
0.11903005838394165,
0.3217919170856476,
0.2634793817996979,
-0.9114410281181335,
0.37730535864830017,
-0.14587247371673584,
-0.21440941095352173,
0.22029991447925568,
-0.9856572151184082,
-0.49037104845046997,
-0.19670166075229645,
0.2023855298757553,
-0.2381363958120346,
0.3755491375923157,
0.08522728830575943,
0.019239362329244614,
-0.4377827048301697,
-0.10062585026025772,
0.186522975564003,
-0.1983874887228012,
-0.07653261721134186,
0.11974316090345383,
0.21764041483402252,
0.09036409109830856,
0.1549307107925415,
-0.40056097507476807,
0.8547003865242004,
-0.017523448914289474,
-0.032436955720186234,
0.08530484139919281,
0.508644700050354,
0.5841310024261475,
-0.03210916742682457,
-0.2320435345172882,
0.1566830426454544,
-0.41468167304992676,
0.4705803692340851,
-0.11072943359613419,
-0.22433453798294067,
-0.03580453246831894,
-1.0812350511550903,
0.05878342688083649,
0.11903608590364456,
-0.750760555267334,
-0.40013328194618225,
0.022905858233571053,
-0.06719715148210526,
0.08573101460933685,
0.1163371130824089,
-0.05801300331950188,
-0.7407020926475525,
0.1897035539150238,
-0.2993655800819397,
0.390484094619751,
-0.15318343043327332,
-0.14418525993824005,
-0.280293732881546,
0.020218823105096817,
-0.07660993933677673,
0.21555137634277344,
-0.1590576171875,
-0.16441403329372406,
0.25596702098846436,
-0.17665566504001617,
-0.31985992193222046,
-0.46799230575561523,
0.47509294748306274,
0.3239426910877228,
-0.3629494309425354,
-0.15679001808166504,
0.487145334482193,
0.3192977011203766,
0.4523812234401703,
0.4782789349555969,
0.37657105922698975,
0.3275836706161499,
0.062104687094688416,
0.8629840612411499,
-0.3514099419116974,
-0.6373321413993835,
-0.7637427449226379,
-0.4763799011707306,
0.208493173122406,
-0.9331052899360657,
-0.33886873722076416,
1.0696252584457397,
-1.0769447088241577,
0.040493134409189224,
0.000695231428835541,
-0.20590268075466156,
0.14035062491893768,
1.019071102142334,
-0.19853034615516663,
-0.3220877945423126,
-0.0357322134077549,
0.7486218810081482,
-0.33048683404922485,
0.29075494408607483,
-0.0457424633204937,
-0.419656366109848,
0.5529528260231018,
-0.22036480903625488,
-0.44857269525527954,
0.5050647854804993,
0.12571576237678528,
-1.2324045896530151,
0.21020428836345673,
0.06622582674026489,
0.0380791537463665,
-1.0388239622116089,
-0.12299937754869461,
0.14311210811138153,
-0.28390175104141235,
-0.6365585327148438,
0.2135719209909439,
0.6682122349739075,
0.4371502101421356,
-0.3508414030075073,
-0.417208731174469,
-0.008213057182729244,
0.16089755296707153,
0.4953312575817108,
-0.11195109039545059,
-0.2652076184749603,
-0.30375638604164124,
-0.3954585790634155,
-0.05990768224000931,
0.21978966891765594,
0.03320010378956795,
0.23819983005523682,
-0.08365725725889206,
-0.3320762515068054,
-0.056211117655038834,
0.25312861800193787,
0.14358384907245636,
0.10984661430120468,
-0.3401106297969818,
0.40986526012420654,
-0.11598590016365051,
-0.8559684157371521,
-0.16422253847122192,
0.024884112179279327,
-1.086364507675171,
-0.22004365921020508,
-0.3392156958580017,
0.23697100579738617,
0.12197607755661011,
0.08809073269367218,
-0.4833034873008728,
0.2352016270160675,
-0.3127456307411194,
-0.006339153740555048,
-0.17812491953372955,
-0.4270437955856323,
0.057399507611989975,
-0.6188439726829529,
0.3504239618778229,
0.17575079202651978,
-0.13316671550273895,
-0.25867760181427,
0.21933622658252716,
1.092559576034546,
0.766069233417511,
-0.06060440093278885,
-0.2724052667617798,
-0.018609600141644478,
-0.11240264028310776,
-0.29322588443756104,
0.051812794059515,
0.5150543451309204,
-0.33290353417396545,
-0.2402023822069168,
-0.08236642926931381,
0.3258827328681946,
0.5728340148925781,
-0.23695458471775055,
-0.4359643757343292,
-0.18587079644203186,
0.4321898818016052,
0.005919961724430323,
0.5614193081855774,
0.5249860286712646,
-0.022141393274068832,
-0.252370685338974,
-0.4326111376285553,
-0.41520845890045166,
-0.18201982975006104,
0.056852493435144424,
-0.6193885207176208,
-0.4121573269367218,
0.23133686184883118,
-0.26304182410240173,
0.16074202954769135,
0.24700449407100677,
-0.32405978441238403,
-0.5202280879020691,
0.28512221574783325,
0.1852012425661087,
-0.27493906021118164,
-0.050217676907777786,
0.13068056106567383,
-0.05128927528858185,
0.04431764408946037,
0.3879546821117401,
-0.8326237797737122,
0.0994550809264183,
0.058146409690380096,
-0.660727858543396,
-0.06222737953066826,
0.10313606262207031,
-0.18140646815299988,
-0.6829842329025269,
-0.2214927226305008,
-0.5082525610923767,
-0.06547346711158752,
0.06082139164209366,
0.6322985291481018,
0.03769863024353981,
0.27174320816993713,
-0.3209863305091858,
-0.4402569830417633,
0.10985655337572098,
0.08028459548950195,
0.2662992477416992,
-0.32617244124412537,
0.07632924616336823,
-0.05297442153096199,
0.37323713302612305,
-0.24520401656627655,
0.12989193201065063,
0.020612899214029312,
0.8576077222824097,
0.2993537485599518,
-0.3052975535392761,
-0.42899957299232483,
-0.24921941757202148,
0.465052992105484,
-0.027324039489030838,
-0.3217534124851227,
-0.24124863743782043,
-0.48211973905563354,
0.09123208373785019,
-0.3973851501941681,
0.020512547343969345,
-0.670627772808075,
0.1364704817533493,
-0.2431780844926834,
0.13449275493621826,
0.12139268219470978,
0.6653321385383606,
0.44985106587409973,
-0.02159752883017063,
0.16538028419017792,
-0.3486868739128113,
0.12035033851861954,
0.2042054980993271,
0.19720789790153503,
-0.6117597818374634,
-0.5694748163223267,
0.21469762921333313,
0.12212228029966354,
0.2925078570842743,
-0.5750588178634644,
0.10816577076911926,
-0.30066031217575073,
-0.054720547050237656,
-0.7798311710357666,
0.25186315178871155,
0.026040388271212578,
-0.7892724871635437,
-0.3168981671333313,
0.07203409820795059,
0.3708418309688568,
0.1877829134464264,
-0.0397864505648613,
0.3664432764053345,
0.05337020009756088,
-0.5747858881950378,
0.6694216728210449,
0.5485875606536865,
0.05909019708633423,
0.07367359101772308,
0.09626616537570953,
0.49401840567588806,
0.11959201842546463,
-0.41412848234176636,
-0.31757718324661255,
0.340135395526886,
-0.012496818788349628,
0.2577018439769745,
-0.27208632230758667,
-0.6591358184814453,
-0.05629124864935875,
-0.5911967158317566,
-0.48059991002082825,
0.49997320771217346,
0.25468024611473083,
0.1995370239019394,
0.8569449186325073,
0.8383042812347412,
0.08982886373996735,
-0.15515100955963135,
0.6791310906410217,
-0.36442047357559204,
0.3198351263999939,
0.16522859036922455,
0.12436197698116302,
0.6041418313980103,
0.5498778820037842,
0.2486153542995453,
0.31776225566864014,
0.40109655261039734,
0.48624899983406067,
0.36578136682510376,
-0.3524666726589203,
0.17047734558582306,
-0.15474562346935272,
1.1485763788223267,
0.45533493161201477,
-0.0867735892534256,
-0.28023117780685425,
0.2274986356496811,
0.3856011927127838,
0.10026843100786209,
0.022657642140984535,
0.030927786603569984,
0.4562670886516571,
0.029941407963633537,
-0.11320627480745316,
-0.39750179648399353,
-0.06739960610866547,
-0.3844653367996216,
0.7284170389175415,
0.4274044334888458,
-0.1670626997947693,
-1.0389866828918457,
0.4697735607624054,
0.1420779675245285,
0.14290408790111542,
-0.187790185213089,
0.6370213031768799,
-0.7552998065948486,
0.09491360187530518,
-0.2139771431684494,
0.6544585227966309,
0.12911993265151978,
-0.07295235246419907,
0.19192339479923248,
-0.4359419047832489,
-0.304022878408432,
-0.05196830630302429,
-0.14842578768730164,
-0.7071937322616577,
0.30744636058807373,
-0.24799111485481262,
-0.1401805728673935,
0.45451387763023376,
-0.4324657917022705,
-0.034389518201351166,
-0.11483551561832428,
-0.19983477890491486,
0.03770691901445389,
-0.4595041275024414,
-0.21447870135307312,
0.06303533166646957,
0.16997641324996948,
0.04814957454800606,
-0.09567911177873611,
-0.6407430171966553,
0.4075167775154114,
0.3207490146160126,
-0.32599106431007385,
0.028061578050255775,
0.05003354325890541,
0.05602177232503891,
0.5091878175735474,
0.4243289530277252,
-0.2250290960073471,
0.03736444190144539,
-0.21144744753837585,
0.45674097537994385,
0.0631258487701416,
0.5298599004745483,
-1.0594630241394043,
-0.23966698348522186,
-0.24778535962104797,
-0.2968944013118744,
0.38062459230422974,
0.2542599141597748,
-0.39373379945755005,
0.21520109474658966,
0.23327447474002838,
0.03269386664032936,
0.5717928409576416,
-0.27535420656204224,
-0.2782244086265564,
-0.4090206027030945,
-0.21865031123161316,
-0.6251602172851562,
0.27395275235176086,
-0.16724109649658203,
-0.5133317708969116,
-0.08815233409404755,
0.23303978145122528,
0.20357215404510498,
-0.1621347963809967,
0.4222726821899414,
-0.28305357694625854,
-0.5929902791976929,
-0.65788334608078,
0.2917918860912323,
-0.5149941444396973,
0.5639335513114929,
0.03908625617623329,
0.2667570412158966,
0.0658082589507103,
-0.06461985409259796,
-0.3042376935482025,
-0.4113195836544037,
0.35679659247398376,
0.2844158113002777,
-0.14744418859481812,
0.5776058435440063,
0.0671931654214859,
-0.3699084222316742,
-0.4764769673347473,
0.19279499351978302,
-0.36738938093185425,
-0.28259021043777466,
-0.3389333188533783,
-0.25604549050331116,
-0.6011581420898438,
-0.32208165526390076,
-0.1418422907590866,
-0.4144374132156372,
-0.14849631488323212,
-0.22624169290065765
] |
Liver is a vital organ with many important functions, and the maintenance of normal hepatic function is necessary for health. As an essential mechanism for maintaining cellular homeostasis, autophagy plays an important role in ensuring normal organ function. Studies have indicated that the degeneration of hepatic function is associated with autophagic deficiency in aging liver. However, the underlying mechanisms still remain unclear. The serine protease Omi/HtrA2 belongs to the HtrA family and promotes apoptosis through either the caspase-dependent or caspase-independent pathway. Mice lacking Omi/HtrA2 exhibited progeria symptoms (premature aging), which were similar to the characteristics of autophagic insufficiency. In this study, we demonstrated that both the protein level of Omi/HtrA2 in liver and hepatic function were reduced as rats aged, and there was a positive correlation between them. Furthermore, several autophagy-related proteins (LC3II/I, Beclin-1 and LAMP2) in rat liver were decreased significantly with the increasing of age. Finally, inhibition of Omi/HtrA2 resulted in reduced autophagy and hepatic dysfunction. In conclusion, these results suggest that Omi/HtrA2 participates in age-related autophagic deficiency in rat liver. This study may offer a novel insight into the mechanism involved in liver aging. | [
-0.007931968197226524,
0.01700975000858307,
-0.007069035433232784,
0.004902294836938381,
-0.0049306428991258144,
-0.015636462718248367,
0.012193586677312851,
0.014439452439546585,
-0.015095456503331661,
-0.021217260509729385,
-0.02272920310497284,
0.007268266286700964,
-0.019802508875727654,
0.02835199609398842,
-0.0033445481676608324,
0.03996846824884415,
-0.017769863829016685,
-0.004929675720632076,
0.0069363615475595,
-0.041788499802351,
0.008810609579086304,
-0.02454855665564537,
0.011487900279462337,
-0.021751295775175095,
-0.03271204233169556,
-0.012357328087091446,
-0.009934752248227596,
-0.006274217739701271,
0.038107775151729584,
0.010553969070315361,
0.005813912488520145,
-0.014496915973722935,
-0.01455115806311369,
0.00315097882412374,
0.009025903418660164,
0.056922271847724915,
-0.00041479559149593115,
0.030417922884225845,
0.019318366423249245,
-0.0057825250551104546,
0.03254057839512825,
-0.004607457667589188,
0.0053480928763747215,
0.0006800107657909393,
-0.007711002603173256,
-0.0029033133760094643,
0.0032484224066138268,
0.004693330265581608,
-0.004094910807907581,
0.01276281289756298,
-0.01846555806696415,
-0.031088272109627724,
-0.00937483087182045,
0.0008213596884161234,
-0.0072070821188390255,
0.021664738655090332,
0.02105715125799179,
-0.019497137516736984,
-0.01730469986796379,
0.02234894223511219,
-0.011472811922430992,
-0.04627058282494545,
-0.007196004968136549,
0.014442725107073784,
-0.020466366782784462,
-0.06666965782642365,
-0.06544141471385956,
0.00722297839820385,
-0.0052455211989581585,
-0.020465856418013573,
-0.011470415629446507,
0.004592408891767263,
0.0005802735686302185,
-0.01542857475578785,
-0.0026017185300588608,
0.009829254820942879,
-0.0033091166988015175,
0.008846512995660305,
0.037910692393779755,
0.0027294268365949392,
0.02012072503566742,
-0.027330907061696053,
-0.00850150641053915,
0.012846395373344421,
0.00913267582654953,
0.024431776255369186,
-0.003935092594474554,
-0.001994593068957329,
0.010297750122845173,
-0.004195383749902248,
-0.0016690699849277735,
0.021588139235973358,
-0.008188627660274506,
-0.003072453662753105,
-0.012508158572018147,
-0.021286997944116592,
0.01270923763513565,
0.023170698434114456,
-0.013032144866883755,
-0.0020541814155876637,
-0.010564684867858887,
0.003817078424617648,
0.015794552862644196,
0.0021643242798745632,
-0.008202171884477139,
0.013365799561142921,
0.01674266718327999,
-0.00739522697404027,
0.024155929684638977,
0.01717672124505043,
-0.01270472351461649,
0.006365583743900061,
-0.011105697602033615,
0.011959955096244812,
-0.016561705619096756,
-0.01808779127895832,
-0.014313320629298687,
0.023820742964744568,
0.011132365092635155,
-0.011007657274603844,
0.02060060016810894,
0.011915136128664017,
0.008401233702898026,
-0.0105645302683115,
-0.000962999474722892,
-0.00429799547418952,
0.018089517951011658,
-0.007738333195447922,
-0.015693191438913345,
-0.022317897528409958,
-0.009084858000278473,
0.012103223241865635,
0.03585603088140488,
0.00014740624465048313,
0.024397065863013268,
0.007741388864815235,
-0.025811895728111267,
-0.013224175199866295,
0.00036852038465440273,
-0.02755676582455635,
0.025060925632715225,
0.00028969591949135065,
0.007566508371382952,
0.0026009941939264536,
0.024635791778564453,
-0.0019862200133502483,
0.01917026750743389,
0.006495859939604998,
0.036079566925764084,
-0.013994506560266018,
-0.014553510583937168,
0.00758054293692112,
0.002479962771758437,
-0.014310178346931934,
0.00002250075340270996,
0.004714366979897022,
-0.011799396015703678,
-0.01645110361278057,
0.003113622311502695,
0.009520648047327995,
0.01659555360674858,
-0.005693183280527592,
0.03179776668548584,
0.01030514296144247,
0.018465839326381683,
-0.002125900238752365,
-0.011204468086361885,
-0.010313881561160088,
0.012730625458061695,
0.009173644706606865,
-0.021678026765584946,
0.002152696019038558,
0.004251847043633461,
0.0105204489082098,
-0.005765249487012625,
-0.009684341959655285,
0.01516070868819952,
0.011603358201682568,
-0.009069751016795635,
0.06603702902793884,
0.021502157673239708,
0.02775486931204796,
-0.02902640588581562,
0.02668614313006401,
0.020169612020254135,
-0.003782921237871051,
-0.005339392926543951,
-0.015210406854748726,
0.02692047506570816,
-0.003556911600753665,
0.004146750085055828,
0.007053903304040432,
0.0012001574505120516,
0.005153053905814886,
-0.009081102907657623,
0.003955754917114973,
0.018942400813102722,
0.010330510325729847,
-0.008534695021808147,
-0.008070830255746841,
-0.01151588186621666,
-0.004700137302279472,
0.018315378576517105,
-0.019003771245479584,
-0.02442185766994953,
0.00258388789370656,
-0.009477815590798855,
-0.03218343108892441,
0.008062330074608326,
0.015298064798116684,
0.01018018089234829,
-0.0010464435908943415,
-0.006398017052561045,
-0.015795670449733734,
-0.0031583271920681,
0.009450769983232021,
0.0243872981518507,
0.018205001950263977,
-0.0074713872745633125,
-0.01373211294412613,
0.0013234246289357543,
0.0008456280920654535,
0.027690546587109566,
0.005369130056351423,
-0.004235123284161091,
-0.016759231686592102,
0.011868384666740894,
0.01505703292787075,
-0.052355192601680756,
0.016706136986613274,
-0.02114507555961609,
-0.002147953025996685,
-0.012690694071352482,
0.020584752783179283,
0.019697636365890503,
0.020004838705062866,
0.009474672377109528,
-0.006186334416270256,
0.02238617092370987,
-0.0124952532351017,
0.009406538680195808,
0.008254854939877987,
0.017404161393642426,
-0.021221933886408806,
-0.0037020151503384113,
-0.00023613683879375458,
-0.047542743384838104,
-0.015348955057561398,
0.021720480173826218,
-0.03369412571191788,
0.005379658658057451,
0.019653361290693283,
-0.01047756988555193,
-0.0035492945462465286,
0.0008519381517544389,
-0.01582499034702778,
0.0261855386197567,
-0.042342983186244965,
0.027510879561305046,
-0.007029949687421322,
-0.0020261702593415976,
0.009738403372466564,
0.030006764456629753,
-0.017802324146032333,
0.007815776392817497,
-0.01622128114104271,
0.002327599562704563,
-0.016438571736216545,
-0.014141611754894257,
-0.009589319117367268,
0.007746398914605379,
-0.006804290227591991,
-0.0007391383405774832,
-0.08114718645811081,
-0.01558795664459467,
-0.012956846505403519,
0.004534702282398939,
0.006951125804334879,
0.0022948002442717552,
0.008491484448313713,
-0.00610273377969861,
0.0016046836972236633,
-0.022147979587316513,
0.01458766683936119,
0.02580474317073822,
-0.005463436245918274,
-0.0410756841301918,
0.0011371716391295195,
-0.003325685393065214,
0.01058567501604557,
0.0293441042304039,
0.01069040410220623,
-0.0006190664134919643,
0.019151370972394943,
-0.008256232365965843,
0.008811457082629204,
0.0031817853450775146,
-0.00002636713907122612,
0.002878212369978428,
0.01716817170381546,
0.002997149247676134,
0.00242910860106349,
0.01231508981436491,
-0.023104246705770493,
0.028994206339120865,
-0.0018388512544333935,
0.033458638936281204,
0.02017199620604515,
0.002672201953828335,
0.018692700192332268,
0.0003003251040354371,
-0.02124883234500885,
0.02188778482377529,
-0.026582181453704834,
0.015868399292230606,
0.01274161972105503,
-0.013021592982113361,
0.024296270683407784,
-0.014699304476380348,
0.014179226011037827,
-0.01801237463951111,
0.006730102002620697,
-0.005601849406957626,
0.020996153354644775,
-0.00960592646151781,
0.0012426769826561213,
0.021624218672513962,
-0.00786968506872654,
0.00302168563939631,
0.014120489358901978,
0.01664997637271881,
-0.015714097768068314,
-0.004585825838148594,
0.008738860487937927,
-0.014093800447881222,
-0.020797336474061012,
0.015239651314914227,
0.01240807306021452,
0.007436245679855347,
0.016918759793043137,
0.02277018129825592,
-0.005359527189284563,
0.01723150722682476,
0.007705735974013805,
-0.004195030778646469,
-0.005811894312500954,
-0.007091667503118515,
0.004380310885608196,
-0.01613372005522251,
-0.013602904975414276,
0.007846157066524029,
0.018992893397808075,
-0.005618640687316656,
-0.048246368765830994,
-0.013075495138764381,
-0.023635877296328545,
0.014164545573294163,
-0.010133760049939156,
-0.035680074244737625,
0.0012212467845529318,
0.015062419697642326,
0.01688610017299652,
-0.013814670965075493,
-0.00991023052483797,
0.008629863150417805,
-0.0221116803586483,
0.009448881261050701,
0.036082811653614044,
0.007613357622176409,
0.017253518104553223,
-0.021904077380895615,
0.010868754237890244,
0.008155560120940208,
-0.05177175626158714,
0.013021048158407211,
0.01797346957027912,
-0.014295851811766624,
0.014617715030908585,
0.01694314554333687,
0.006553896702826023,
0.025681335479021072,
0.0004045390523970127,
-0.0026025541592389345,
0.010922577232122421,
0.0025670125614851713,
-0.005228270310908556,
0.0034401332959532738,
0.015649400651454926,
0.005127884913235903,
-0.009207867085933685,
-0.026192789897322655,
0.07115031778812408,
0.026648595929145813,
-0.015257073566317558,
-0.005992140155285597,
0.007112003397196531,
-0.005320589058101177,
-0.019634656608104706,
0.017042316496372223,
-0.006708730943500996,
-0.008574123494327068,
0.015322054736316204,
0.033417243510484695,
-0.01509153377264738,
0.019537556916475296,
-0.01692543365061283,
0.004741663113236427,
-0.0062014758586883545,
-0.057990461587905884,
0.019036322832107544,
0.00589913222938776,
-0.026943642646074295,
-0.004119004122912884,
-0.0009614888112992048,
0.005701933056116104,
0.012759437784552574,
-0.0209586713463068,
-0.03311816230416298,
-0.014190325513482094,
-0.032261162996292114,
0.005386414006352425,
-0.015508627519011497,
0.048218466341495514,
-0.006179746240377426,
-0.0023444117978215218,
0.003493429161608219,
0.02287854626774788,
0.0035458728671073914,
-0.025153513997793198,
0.023728419095277786,
-0.005311001092195511,
0.01779649220407009,
-0.016266709193587303,
-0.000017762184143066406,
0.0014856801135465503,
0.005283232778310776,
-0.0015556677244603634,
-0.021124068647623062,
-0.008427226915955544,
0.004462015815079212,
-0.00047145551070570946,
-0.0014446929562836885,
-0.002377517521381378,
0.009883169084787369,
-0.04521811008453369,
0.020936883985996246,
-0.010236740112304688,
0.05522308498620987,
-0.01282901968806982,
-0.022547122091054916,
-0.0035700525622814894,
-0.007287386804819107,
0.006108897738158703,
0.019463734701275826,
-0.007803631946444511,
0.017551463097333908,
-0.028288573026657104,
0.028792375698685646,
-0.008130814880132675,
0.03483568876981735,
-0.004264578688889742,
0.011625031009316444,
0.006664523854851723,
-0.019258901476860046,
-0.0069803763180971146,
-0.010523224249482155,
-0.032289206981658936,
0.04122838377952576,
-0.025707334280014038,
0.04666764289140701,
-0.036015886813402176,
0.0045567890629172325,
0.042750872671604156,
0.0059841410256922245,
-0.013160403817892075,
0.05653959885239601,
0.01679525338113308,
0.019300518557429314,
-0.07447695732116699,
-0.0036889833863824606,
0.007831753231585026,
-0.008795507252216339,
0.0015215385938063264,
0.015443241223692894,
-0.019428472965955734,
-0.03563364967703819,
0.0077368998900055885,
-0.0028778966516256332,
-0.011916878633201122,
-0.0008507722523063421,
0.018651962280273438,
0.02152165025472641,
0.011424895375967026,
-0.030025605112314224,
-0.005409478209912777,
0.012465978041291237,
-0.0075020333752036095,
-0.02472318522632122,
0.04898271709680557,
-0.030254555866122246,
-0.005681650713086128,
0.019118795171380043,
-0.003589592408388853,
-0.07998286932706833,
-0.016391249373555183,
0.00844265054911375,
-0.007654513698071241,
0.023696569725871086,
-0.002525529358536005,
0.005442359484732151,
-0.0031982730142772198,
0.032236579805612564,
-0.018503636121749878,
0.014920638874173164,
-0.013441698625683784,
0.013585099019110203,
-0.005604595877230167,
-0.019514407962560654,
-0.014386525377631187,
0.012674400582909584,
0.008126718923449516,
-0.009057523682713509,
0.0018515810370445251,
-0.00483158603310585,
0.013135365210473537,
-0.011828674003481865,
0.005756013095378876,
-0.011397553607821465,
-0.01769346557557583,
-0.02218521758913994,
0.009583747014403343,
0.00654646847397089,
-0.0075848898850381374,
-0.03169329836964607,
-0.004037337377667427,
0.002476248424500227,
-0.0232432559132576,
-0.020949412137269974,
-0.014776382595300674,
0.0024630369152873755,
-0.00450443709269166,
-0.03593892604112625,
-0.021844400092959404,
-0.0073243300430476665,
-0.0127603430300951,
-0.01799958199262619,
-0.007074893452227116,
0.016627036035060883,
-0.012086397036910057,
0.005856488831341267,
-0.002848723903298378,
-0.0074624838307499886,
-0.0063181594014167786,
0.006578752771019936,
-0.026902811601758003,
0.018885958939790726,
-0.01614602655172348,
-0.00543758412823081,
0.016528770327568054,
-0.0022030638065189123,
0.005743419285863638,
-0.031364113092422485,
0.0023350133560597897,
-0.020235856994986534,
0.004920539911836386,
0.010817315429449081,
0.07064945995807648,
-0.0028589079156517982,
0.011347858235239983,
-0.02849828079342842,
-0.0009583928622305393,
0.005202234257012606,
0.01754627749323845,
-0.03577845171093941,
0.01826532930135727,
0.0008681237231940031,
-0.015892822295427322,
-0.0035503983963280916,
0.0011610465589910746,
0.014492867514491081,
-0.0068685454316437244,
0.004246460273861885,
-0.023224372416734695,
0.018061237409710884,
-0.015731140971183777,
-0.007191554643213749,
-0.007903894409537315,
-0.005089334212243557,
-0.05984748154878616,
-0.008635513484477997,
0.008326966315507889,
0.011253347620368004,
0.00021798140369355679,
0.024028953164815903,
-0.03433981537818909,
-0.022355783730745316,
-0.02244890108704567,
-0.013523388653993607,
0.0026865515392273664,
-0.008262352086603642,
0.013134323060512543,
-0.008783179335296154,
0.00957268476486206,
0.006781003437936306,
-0.02672608382999897,
-0.045086026191711426,
0.031931038945913315,
-0.0036374693736433983,
-0.005267134867608547,
-0.007213625591248274,
0.014619266614317894,
-0.01822207309305668,
0.012602647766470909,
0.01832166127860546,
-0.0297174621373415,
0.016573023051023483,
0.01707392744719982,
0.006502377800643444,
-0.0012701014056801796,
-0.018181579187512398,
0.004179546609520912,
-0.013676850125193596,
-0.013401547446846962,
0.009111626073718071,
-0.02661387249827385,
-0.0183887742459774,
-0.0009425245225429535,
-0.0061783683486282825,
-0.013338429853320122,
-0.02057870663702488,
0.0021382877603173256,
-0.0024338639341294765,
0.018798889592289925,
-0.0112821776419878,
-0.012321068905293941,
0.01993129588663578,
0.014622889459133148,
-0.006377990357577801,
0.007656469941139221,
0.00734067102894187,
0.0005795644829049706,
0.0061429087072610855,
0.005214664153754711,
0.011485954746603966,
0.022700749337673187,
0.018471747636795044,
-0.002556836698204279,
0.02967742457985878,
0.04171890392899513,
0.00848428439348936,
-0.005835765972733498,
0.00041628675535321236,
-0.02540607377886772,
-0.023054910823702812,
-0.006799369119107723,
0.01305343583226204,
-0.005272864364087582,
-0.0029760142788290977,
0.0012106015346944332,
0.031352318823337555,
0.015429781749844551,
0.03590945154428482,
0.01086479052901268,
0.0024584122002124786,
-0.009198799729347229,
0.013930493965744972,
0.011925606057047844,
-0.000454154796898365,
-0.010843275114893913,
-0.001340491697192192,
0.021012380719184875,
-0.018001308664679527,
0.008328705094754696,
0.03762591630220413,
0.03163059800863266,
0.005196377635002136,
0.025186046957969666,
0.05019504576921463,
0.03099430911242962,
-0.008127450942993164,
-0.009124716743826866,
0.027064623311161995,
-0.024021431803703308,
-0.01036617998033762,
0.021994244307279587,
-0.015516528859734535,
-0.009435292333364487,
-0.00838423054665327,
0.005208007525652647,
0.01635092869400978,
-0.014130936935544014,
-0.02839982509613037,
-0.01231776736676693,
-0.023580018430948257,
0.028764262795448303,
0.01486627571284771,
0.01857253536581993,
-0.05016116052865982,
-0.01706412434577942,
0.008905978873372078,
-0.0036202312912791967,
-0.00081630889326334,
0.010234699584543705,
0.011379733681678772,
-0.007829198613762856,
0.020865628495812416,
0.014527568593621254,
-0.0029224902391433716,
-0.0013459473848342896,
0.0018188909161835909,
0.010425647720694542,
-0.016458040103316307,
-0.0022423388436436653,
-0.011982878670096397,
0.014467536471784115,
-0.017453160136938095,
0.018532175570726395,
0.010047060437500477,
0.02909131348133087,
-0.011174926534295082,
-0.010192999616265297,
0.02753341943025589,
0.020880095660686493,
-0.009528756141662598,
-0.012260865420103073,
-0.013398729264736176,
-0.020802505314350128,
-0.02126229926943779,
-0.04007676616311073,
0.037445127964019775,
0.005072982981801033,
0.008155478164553642,
0.008574082516133785,
-0.0012747971341013908,
0.014702580869197845,
0.009967101737856865,
-0.017728138715028763,
0.004151677247136831,
0.010873989202082157,
-0.019270870834589005,
-0.029935840517282486,
-0.004534826148301363,
-0.015622793696820736,
-0.01663363352417946,
0.024980459362268448,
0.0151616670191288,
-0.01354196760803461,
0.004049787297844887,
-0.013350673019886017,
-0.0077086859382689,
0.0066638486459851265,
-0.0215274840593338,
-0.006618529092520475,
0.0046922629699110985,
-0.01817736029624939,
0.007528218440711498,
-0.035220615565776825,
0.005319157615303993,
0.0054090251214802265,
0.001462404616177082,
-0.01673341542482376,
0.0187296774238348,
0.002000995445996523,
-0.03322342783212662,
0.00004984857514500618,
0.0067047178745269775,
0.0064464956521987915,
0.0047496468760073185
] | [
0.2864317297935486,
0.11403622478246689,
0.14825958013534546,
-0.06839914619922638,
0.3034549355506897,
0.05039110779762268,
0.14210274815559387,
0.28836870193481445,
-0.2574349343776703,
-0.8303133249282837,
0.23344118893146515,
0.2742055058479309,
-0.44457367062568665,
-0.10239499807357788,
-0.08554428815841675,
0.30454689264297485,
0.9593385457992554,
0.5206470489501953,
-0.05105958133935928,
-0.3605582118034363,
-0.23310726881027222,
0.23904290795326233,
0.9490103721618652,
0.08598235994577408,
0.20936180651187897,
-0.1518077552318573,
0.19637227058410645,
-0.15424150228500366,
0.26411670446395874,
0.10270291566848755,
-0.16220144927501678,
0.41569963097572327,
0.20552818477153778,
-0.32770609855651855,
-0.44270649552345276,
0.0348629467189312,
-0.14795266091823578,
-0.4108283817768097,
0.12155236303806305,
0.34305641055107117,
-0.5077646374702454,
-0.025910111144185066,
0.11324269324541092,
0.5999503135681152,
0.011876625940203667,
-0.17862339317798615,
-1.2436267137527466,
0.8920965194702148,
0.0926537960767746,
0.5089175701141357,
0.09502435475587845,
0.01171337440609932,
-0.11559751629829407,
0.40789657831192017,
0.2739301919937134,
0.21293266117572784,
-0.9173795580863953,
0.07148446142673492,
0.045551665127277374,
-0.28738078474998474,
0.18742871284484863,
0.04094583913683891,
-0.46979475021362305,
0.09253759682178497,
-0.03059171698987484,
0.30589520931243896,
0.11346825957298279,
-0.0385575145483017,
-0.32393786311149597,
-0.07180341333150864,
-0.049002084881067276,
-0.7645674347877502,
-0.11197838932275772,
0.49949297308921814,
-0.19900661706924438,
-0.5635069608688354,
-0.3822905123233795,
-0.17467258870601654,
-0.14984822273254395,
-0.23382095992565155,
0.1678411364555359,
0.1021181270480156,
0.290616899728775,
0.7587867975234985,
0.024107979610562325,
-0.06348828226327896,
-0.19066710770130157,
0.6669435501098633,
-0.5318328142166138,
-0.02380739152431488,
0.08942952007055283,
-0.030931273475289345,
0.4709574282169342,
0.05888719856739044,
0.008705634623765945,
0.2984139323234558,
0.34101682901382446,
-0.227121964097023,
0.1434125006198883,
0.0699290782213211,
-0.3816511332988739,
0.24714864790439606,
0.017000993713736534,
-0.4824276864528656,
-0.1747032105922699,
-0.3398539125919342,
0.0492781363427639,
-0.4113077223300934,
-0.16375868022441864,
0.06452836096286774,
-0.7330967783927917,
0.016909226775169373,
-0.2572118043899536,
-0.26333606243133545,
-0.10627180337905884,
0.29510626196861267,
-0.17930197715759277,
-0.5773565173149109,
0.1726231575012207,
-0.36251330375671387,
0.36677807569503784,
0.7889449596405029,
-0.2772212028503418,
0.2990347146987915,
-0.2454349845647812,
-0.48448285460472107,
0.6143545508384705,
-0.21500062942504883,
0.20250682532787323,
0.5851833820343018,
0.4887983202934265,
0.6896141767501831,
-0.5755075216293335,
-0.1461649090051651,
-0.08659067749977112,
-0.02354692667722702,
0.42536836862564087,
0.049508560448884964,
0.3404995799064636,
-0.02327802963554859,
-0.5689295530319214,
-0.6596643328666687,
-0.16094902157783508,
-0.11973720788955688,
0.04738100618124008,
-0.19757992029190063,
-0.05407439172267914,
-0.10325469821691513,
0.35704267024993896,
-0.8020732998847961,
0.26435813307762146,
-0.44899192452430725,
-0.5452864766120911,
0.06931257247924805,
-0.022242384031414986,
0.531397819519043,
0.5197312831878662,
-0.6548498272895813,
0.18486574292182922,
0.412415474653244,
0.36421021819114685,
-0.5416796803474426,
-0.18464265763759613,
-0.6638129949569702,
0.2015485018491745,
0.15203911066055298,
0.1791105568408966,
0.5870864391326904,
0.006973457522690296,
-0.43015056848526,
-0.749001145362854,
-0.215575709939003,
0.36560341715812683,
-0.52166348695755,
0.411247581243515,
-0.314279705286026,
0.6458491683006287,
0.07432489842176437,
0.320528119802475,
0.30132585763931274,
-0.7129138708114624,
-0.01941012777388096,
-0.4000837206840515,
-0.042437419295310974,
0.42054954171180725,
-0.3167990744113922,
0.5704723596572876,
-0.12823721766471863,
0.0002031087497016415,
0.3699916899204254,
-0.1819368451833725,
-0.5069052577018738,
0.7824084162712097,
-0.11015362292528152,
0.9920072555541992,
-0.34461185336112976,
-0.40808022022247314,
0.7093573212623596,
-0.0011790953576564789,
0.10915281623601913,
-0.6189514994621277,
-0.12373588234186172,
0.40363943576812744,
-0.45294463634490967,
-0.922991156578064,
0.1799183487892151,
0.133073091506958,
-0.13197684288024902,
0.22062838077545166,
0.03691374883055687,
0.5015007853507996,
-0.5114350914955139,
-0.20779132843017578,
0.0486774668097496,
0.43970587849617004,
-0.2776784598827362,
-0.20212121307849884,
-0.3656807839870453,
-0.5732026100158691,
-0.15394064784049988,
0.41864845156669617,
-0.4669317305088043,
0.5811964273452759,
0.6421189308166504,
-0.03868499770760536,
0.6472596526145935,
0.6740216016769409,
0.1007094755768776,
0.5725217461585999,
-0.0852569192647934,
0.3089750409126282,
-0.3773382604122162,
0.06931476294994354,
-0.18885456025600433,
-0.17265011370182037,
0.23650634288787842,
-0.026330897584557533,
-0.1649986356496811,
-0.13390177488327026,
-0.23116734623908997,
-0.01737380214035511,
0.2695549726486206,
-0.7082024216651917,
-0.6215479969978333,
-0.03593819960951805,
-0.39729028940200806,
-0.5794310569763184,
0.15099391341209412,
-0.936885416507721,
-0.26246315240859985,
0.06721625477075577,
0.47511816024780273,
0.207717165350914,
-0.6658415198326111,
-0.12469656020402908,
-0.22615453600883484,
0.45005565881729126,
0.4105624854564667,
0.1838143765926361,
-0.796859622001648,
-0.4917401373386383,
-0.09692904353141785,
0.4568334221839905,
0.1729026436805725,
-0.021037321537733078,
-0.486366331577301,
-0.7319665551185608,
-0.3627249598503113,
0.8730799555778503,
0.7067724466323853,
0.8068147897720337,
-0.17050984501838684,
-0.6396564841270447,
-0.010190118104219437,
-0.18818414211273193,
-0.5600858330726624,
-0.14817489683628082,
0.45732349157333374,
-0.18785540759563446,
0.020663555711507797,
0.057629238814115524,
0.8499600887298584,
0.8470373153686523,
-0.13666673004627228,
-0.9353287816047668,
0.47551319003105164,
-0.026347694918513298,
-0.4285678267478943,
-0.42636537551879883,
0.021112525835633278,
-0.0030665516387671232,
0.3617686331272125,
-0.14640146493911743,
-0.09912530332803726,
0.4742024838924408,
-0.25295090675354004,
-0.24042858183383942,
0.41501253843307495,
0.5319393277168274,
-0.5982198715209961,
-0.008252955041825771,
0.18333706259727478,
0.07175491005182266,
-0.08757540583610535,
0.13665777444839478,
0.34346094727516174,
-0.4381389319896698,
0.35922902822494507,
-5.85336971282959,
-0.4119876027107239,
0.17039571702480316,
-0.04485192894935608,
0.34034353494644165,
-0.10710320621728897,
0.2419658601284027,
-0.08602989464998245,
0.47918346524238586,
0.13240095973014832,
0.5572674870491028,
0.5692508220672607,
0.1922692060470581,
-0.0044364118948578835,
-0.28068313002586365,
-0.4682263433933258,
-0.7695288062095642,
-0.19155354797840118,
0.4584135115146637,
-0.04625941067934036,
0.0003374669176992029,
-0.4689001441001892,
-0.212140753865242,
0.9074932336807251,
-0.29729223251342773,
-0.08013655990362167,
-0.7416388392448425,
0.25816503167152405,
-0.13207992911338806,
-0.5906214118003845,
-0.5070856809616089,
-0.016729101538658142,
0.18624098598957062,
-0.3482462167739868,
0.4554610252380371,
-0.3493987023830414,
-0.3354428708553314,
-0.10132889449596405,
-0.20473462343215942,
-0.23657330870628357,
0.2573157250881195,
-0.14602118730545044,
-0.1000702902674675,
-0.32371991872787476,
0.06507270783185959,
0.04212304949760437,
-0.2206704318523407,
0.3987836539745331,
-0.16378195583820343,
0.4255145192146301,
0.21777647733688354,
-0.38855352997779846,
0.1896633803844452,
0.33895087242126465,
0.6379045844078064,
0.23358942568302155,
0.10815934091806412,
0.1684146374464035,
0.1076371893286705,
0.04083339124917984,
-0.2803139090538025,
-0.16808255016803741,
-0.25233787298202515,
0.1380174607038498,
-0.14644527435302734,
0.6071780323982239,
-0.12375465035438538,
-0.7639430165290833,
0.5552010536193848,
0.034181755036115646,
-0.0375678725540638,
0.43432995676994324,
-0.14217907190322876,
-0.7985169291496277,
0.22476625442504883,
-0.17938703298568726,
0.010274973697960377,
0.21149611473083496,
-0.276168555021286,
0.00797711219638586,
-0.1408269703388214,
-0.13242881000041962,
0.22296448051929474,
-0.4887714684009552,
0.2923133373260498,
-0.41041556000709534,
-0.2920133173465729,
0.4477081894874573,
0.056947823613882065,
0.8209342956542969,
0.31525710225105286,
-0.44884106516838074,
0.09173204749822617,
0.45219093561172485,
0.09107929468154907,
0.5347956418991089,
0.2972981333732605,
0.30175358057022095,
0.42014697194099426,
0.3747614324092865,
1.057294249534607,
0.33773842453956604,
-0.6026793122291565,
-0.34048646688461304,
-0.42863303422927856,
0.6552658081054688,
-0.6964137554168701,
0.35713982582092285,
0.5186048150062561,
-0.6734625697135925,
-0.07761482894420624,
-0.007860701531171799,
-0.042726486921310425,
-0.3277541697025299,
0.7089484333992004,
-0.38891348242759705,
-0.3375979959964752,
0.09266401082277298,
0.7651227712631226,
-0.10304209589958191,
0.045816536992788315,
0.4850156903266907,
-0.5749689936637878,
0.2370714247226715,
0.35533201694488525,
0.08080349862575531,
0.4613873064517975,
0.8661553263664246,
-0.41205689311027527,
-0.010377773083746433,
0.7441967129707336,
0.3424127697944641,
-0.048822347074747086,
0.28356167674064636,
0.5744019746780396,
-0.2848200798034668,
-0.4100431799888611,
0.6595010161399841,
0.7050946950912476,
-0.13465048372745514,
0.27679941058158875,
-0.40443137288093567,
-0.15712550282478333,
-0.4168221354484558,
0.35341551899909973,
0.4156806468963623,
-0.3138476610183716,
-0.10990888625383377,
0.037079356610774994,
-0.11120940744876862,
0.002367829205468297,
0.2338324934244156,
-0.3602526783943176,
0.11092337220907211,
-0.38648366928100586,
-0.23259350657463074,
0.3233177959918976,
-0.07290437817573547,
0.025126641616225243,
-0.6857009530067444,
0.11273449659347534,
-0.4960961937904358,
-0.7576543688774109,
-0.18787135183811188,
-0.6441634297370911,
-0.09711141139268875,
0.24102982878684998,
-0.7146448493003845,
-0.2139604389667511,
0.4772774875164032,
-0.4037409722805023,
-0.07077579200267792,
0.23012229800224304,
0.09846946597099304,
0.45646899938583374,
-0.9419481158256531,
-0.2287527620792389,
-0.09661242365837097,
-0.12386929243803024,
0.14169086515903473,
0.13360542058944702,
-0.4246678650379181,
0.04421238973736763,
0.11466313153505325,
0.08417823910713196,
-0.5850753784179688,
0.28652986884117126,
-0.403947651386261,
-0.2977598309516907,
-0.47996771335601807,
0.1464572250843048,
0.005299843847751617,
0.21671269834041595,
-0.002795762848109007,
0.42091506719589233,
0.3183094263076782,
0.137369766831398,
-0.02737027406692505,
0.10565151274204254,
-0.683401346206665,
0.5889435410499573,
0.315576434135437,
-0.3732393980026245,
0.339059442281723,
0.7606985569000244,
0.031667642295360565,
-0.41732537746429443,
0.5087592601776123,
-0.1862982213497162,
0.0006872295634821057,
-0.5088823437690735,
-0.7086033225059509,
0.1150016039609909,
0.6026355028152466,
-0.4000997543334961,
-0.037794265896081924,
0.2573140561580658,
-0.1428418904542923,
0.05191360041499138,
0.08116893470287323,
0.396594375371933,
0.061379171907901764,
-0.1132621169090271,
0.09594579041004181,
-0.7176838517189026,
0.48240548372268677,
0.4052114188671112,
-1.0566776990890503,
0.5207948088645935,
-0.19575965404510498,
-0.07934366166591644,
-0.09076879173517227,
-0.2405557930469513,
-0.0800924152135849,
0.3181474804878235,
-0.8512924313545227,
-0.030887143686413765,
0.18180492520332336,
-0.23906470835208893,
0.3957248032093048,
-0.06977095454931259,
0.6452991962432861,
-0.07838752120733261,
-0.032697588205337524,
-0.2963293492794037,
0.21521258354187012,
0.3452971875667572,
-0.6205824613571167,
-0.23425064980983734,
0.13988523185253143,
0.18477915227413177,
-0.49343451857566833,
0.8771145343780518,
0.32652366161346436,
0.6342154741287231,
-0.4419955611228943,
0.38738226890563965,
-0.3271681070327759,
-0.17781560122966766,
0.36668258905410767,
-0.4931824505329132,
-0.2600271701812744,
0.09067034721374512,
0.2785029709339142,
0.3947814404964447,
0.10542977601289749,
-0.23883086442947388,
-0.4735791087150574,
0.5495820641517639,
-0.21917562186717987,
0.5798875689506531,
-0.1429702639579773,
0.0664457455277443,
0.08164545148611069,
0.16557973623275757,
0.2810664176940918,
-0.5151251554489136,
-0.19509869813919067,
-0.022315237671136856,
0.40177589654922485,
-0.07161525636911392,
-0.27647626399993896,
0.2806606590747833,
-0.5738627314567566,
0.5637395977973938,
-1.1428606510162354,
0.28479745984077454,
-0.2901080548763275,
-0.15216165781021118,
0.07167007774114609,
-0.4010361135005951,
0.007399976719170809,
-0.061584096401929855,
-0.49933677911758423,
0.06863217055797577,
0.12791575491428375,
-0.05473921820521355,
0.27141737937927246,
-0.2354293316602707,
-0.1651926189661026,
-0.3943260908126831,
0.038736436516046524,
0.027552738785743713,
0.32088249921798706,
-0.12697844207286835,
0.4205501079559326,
-0.3284253478050232,
-0.23177748918533325,
-0.9668259620666504,
0.06953929364681244,
0.02915741316974163,
-0.31303882598876953,
0.5471025109291077,
0.16116051375865936,
-0.32087838649749756,
0.18327249586582184,
-0.5705876350402832,
0.015118553303182125,
0.19156880676746368,
0.3544551432132721,
0.27546095848083496,
0.3056321442127228,
0.4011984169483185,
0.0795053243637085,
-0.4706667959690094,
0.3505151569843292,
0.13611246645450592,
0.21259275078773499,
0.26203328371047974,
0.8418086171150208,
0.48315608501434326,
0.30558228492736816,
-0.033997055143117905,
0.8768065571784973,
0.4650287330150604,
-0.08969713747501373,
-0.09697772562503815,
-0.7727506160736084,
-0.09484776109457016,
-0.19690294563770294,
0.8860833048820496,
0.013584043830633163,
-0.07878196984529495,
0.07395295053720474,
0.3281778395175934,
0.26189759373664856,
-0.010267307981848717,
-0.13362649083137512,
-0.25322678685188293,
0.04921208322048187,
0.14725090563297272,
-0.5795011520385742,
-0.28871890902519226,
0.46950870752334595,
-0.3851119875907898,
0.520817756652832,
0.05493368208408356,
-0.6037784814834595,
-0.2263181209564209,
0.11962977796792984,
-0.14868633449077606,
-0.1873287409543991,
0.020078087225556374,
0.6437894105911255,
0.23642441630363464,
0.011048195883631706,
-0.014545528218150139,
-0.4148271679878235,
0.15525546669960022,
-0.34737861156463623,
-0.5308260321617126,
0.009298394434154034,
-0.017359625548124313,
0.10398867726325989,
0.6880777478218079,
-0.07482593506574631,
0.1555079072713852,
-0.33023491501808167,
0.15455439686775208,
0.37057092785835266,
-0.23346644639968872,
0.02092180773615837,
-0.3122261166572571,
-1.0896252393722534,
-0.3781358301639557,
0.13980188965797424,
-0.32523149251937866,
-0.3389733135700226,
0.10025639086961746,
-0.018375787883996964,
-0.038653336465358734,
0.07610633224248886,
0.30227524042129517,
0.16602808237075806,
0.5023724436759949,
-0.5980058908462524,
-0.027309240773320198,
-0.06810960173606873,
0.3953774571418762,
0.21834492683410645,
0.16702115535736084,
0.3274199366569519,
-0.2979617416858673,
0.4458520710468292,
-0.7827996611595154,
0.2591218650341034,
-0.30508875846862793,
-0.42405301332473755,
-0.36055564880371094,
0.3943901062011719,
0.7301653027534485,
0.5950823426246643,
-0.09484385699033737,
0.3359241783618927,
0.33947044610977173,
0.5365957617759705,
0.3085765540599823,
-0.814391016960144,
-0.1616051197052002,
-0.6789286732673645,
0.07316754013299942,
-0.6378953456878662,
0.6199446320533752,
0.14731043577194214,
-0.4564734995365143,
-0.037074241787195206,
0.31158962845802307,
0.18674232065677643,
-0.1908407062292099,
0.4705492854118347,
-0.8523030281066895,
0.6792764663696289,
-0.6253665685653687,
0.010394110344350338,
-0.15263064205646515,
0.1614607870578766,
-0.17904846370220184,
-0.26450198888778687,
0.08520714938640594,
-0.490031361579895,
0.12781304121017456,
0.052134014666080475,
-0.10152850300073624,
-0.14033789932727814,
0.2589268386363983,
-0.19908826053142548,
0.04664701223373413,
-0.8240536451339722,
-0.2228514701128006,
0.5390026569366455,
0.23142606019973755,
-0.26662006974220276,
0.1680629849433899,
0.19318129122257233,
0.13530004024505615,
0.16776221990585327,
0.21525363624095917,
-0.16630423069000244,
0.10516182333230972,
-0.15716569125652313
] |
Background Macrosomia is associated with considerable neonatal and maternal morbidity. Factors that predict macrosomia are poorly understood. The increased rate of macrosomia in the offspring of pregnant women with diabetes and in congenital hyperinsulinaemia is mediated by increased foetal insulin secretion. We assessed the in utero and neonatal role of two key regulators of pancreatic insulin secretion by studying birthweight and the incidence of neonatal hypoglycaemia in patients with heterozygous mutations in the maturity-onset diabetes of the young (MODY) genes HNF4A (encoding HNF-4α) and HNF1A/TCF1 (encoding HNF-1α), and the effect of pancreatic deletion of Hnf4a on foetal and neonatal insulin secretion in mice. | [
-0.015528606250882149,
0.015529878437519073,
-0.011077247560024261,
0.023778777569532394,
0.03647270053625107,
-0.012879075482487679,
0.011162661015987396,
0.005762447603046894,
-0.011441728100180626,
-0.029535578563809395,
-0.00529463030397892,
0.006001111585646868,
-0.012525554746389389,
0.020143991336226463,
-0.03434322774410248,
-0.02095477283000946,
-0.025546323508024216,
0.011631937697529793,
0.005407888442277908,
0.03173793479800224,
0.015664536505937576,
-0.017937690019607544,
0.010759213007986546,
0.04009292647242546,
0.02873026579618454,
0.030191626399755478,
0.03350784629583359,
-0.024603234604001045,
-0.024451568722724915,
-0.0012919942382723093,
-0.0062071410939097404,
0.006660405546426773,
0.007169940043240786,
0.031199077144265175,
0.0060118697583675385,
0.007214458659291267,
0.0031804684549570084,
0.028301695361733437,
-0.015139095485210419,
-0.0043785604648292065,
0.019739292562007904,
-0.014194357208907604,
0.002140674740076065,
-0.003457343205809593,
-0.005002844613045454,
-0.022767940536141396,
-0.002645832486450672,
-0.020565450191497803,
-0.017995601519942284,
0.007638799026608467,
-0.002395292744040489,
-0.025014139711856842,
-0.012261398136615753,
0.00819428265094757,
-0.00662064366042614,
0.009353138506412506,
0.020616885274648666,
-0.009590163826942444,
-0.024643339216709137,
0.006841556169092655,
-0.004735123831778765,
-0.01157864648848772,
0.014912465587258339,
-0.010313207283616066,
-0.026146145537495613,
-0.06695393472909927,
0.0429721474647522,
-0.005864203441888094,
-0.00498614739626646,
0.03126824274659157,
-0.010756251402199268,
0.0059898728504776955,
0.040430136024951935,
0.009896029718220234,
0.007127539254724979,
-0.023790966719388962,
-0.006651637144386768,
0.0006549560930579901,
-0.014088878408074379,
0.017038825899362564,
0.002578149549663067,
-0.00530996173620224,
-0.0395943708717823,
0.0122597124427557,
0.007941252551972866,
0.01564842462539673,
-0.035767264664173126,
0.01838422752916813,
0.004186431877315044,
0.0017934991046786308,
-0.00005901011172682047,
0.025428352877497673,
-0.012044336646795273,
-0.0030425190925598145,
-0.024632040411233902,
-0.005501193460077047,
0.006859743036329746,
0.018326910212635994,
0.000026533380150794983,
-0.011129120364785194,
-0.02902505360543728,
0.0027975705452263355,
0.018464455381035805,
-0.003430662676692009,
-0.0155107993632555,
0.0071044499054551125,
0.01472401525825262,
-0.012771816924214363,
0.022875366732478142,
0.012238017283380032,
-0.010901111178100109,
-0.01036056037992239,
-0.004598558414727449,
0.03963925689458847,
0.031110232695937157,
0.013042015954852104,
-0.012299954891204834,
-0.004278561100363731,
0.009291980415582657,
0.010330332443118095,
0.0049879299476742744,
0.0010881557827815413,
-0.0030461640562862158,
0.01668083854019642,
0.00008051650365814567,
0.0015777596272528172,
0.006182686425745487,
-0.010719708167016506,
0.02249225601553917,
-0.0015235377941280603,
-0.005097826011478901,
-0.0033826599828898907,
-0.0018799281679093838,
0.015997186303138733,
0.02202693186700344,
0.003334144363179803,
-0.01712246611714363,
-0.013274678029119968,
0.002878380473703146,
-0.026116933673620224,
0.01262722723186016,
0.011120835319161415,
-0.0016818196745589375,
0.0018615134758874774,
-0.01045602560043335,
0.005366358906030655,
-0.0190078504383564,
0.009778201580047607,
-0.005298268049955368,
-0.024298379197716713,
0.009662306867539883,
-0.013306637294590473,
-0.01802496612071991,
-0.00978761725127697,
-0.003988861106336117,
-0.029717182740569115,
-0.015295982360839844,
0.008066150359809399,
0.002694573951885104,
0.005905629135668278,
-0.03083665296435356,
-0.010535946115851402,
0.018931372091174126,
0.010577966459095478,
-0.00905967690050602,
-0.01230637077242136,
0.018184276297688484,
0.0010670796036720276,
-0.012536711990833282,
0.006768503226339817,
-0.010647676885128021,
-0.02143646962940693,
0.002483588643372059,
0.008292950689792633,
0.003471718868240714,
0.00040959386387839913,
-0.023482490330934525,
0.00571797788143158,
0.0033650477416813374,
0.06658238172531128,
-0.0047195847146213055,
0.013685567304491997,
-0.018482031300663948,
-0.010029932484030724,
-0.0003574732691049576,
-0.011035138741135597,
0.028879763558506966,
-0.00929927732795477,
0.010294077917933464,
-0.01641993224620819,
0.012660226784646511,
0.00870471354573965,
0.00892626866698265,
0.017943084239959717,
-0.022205296903848648,
0.004077001940459013,
-0.0012526882346719503,
0.007928846403956413,
-0.02050718292593956,
-0.018227066844701767,
0.0046858154237270355,
-0.015681616961956024,
0.04334738850593567,
-0.01657216250896454,
0.043241728097200394,
0.008495109155774117,
0.011402105912566185,
-0.006748152896761894,
0.0038822595961391926,
0.0000704997219145298,
0.023428771644830704,
-0.008368687704205513,
0.016463136300444603,
-0.01374104991555214,
0.019114544615149498,
-0.020775623619556427,
-0.024013156071305275,
0.00460160244256258,
-0.016679976135492325,
-0.012502413243055344,
-0.00004835717845708132,
0.0177654717117548,
-0.0057523371651768684,
-0.01442654523998499,
0.024753637611865997,
-0.043518003076314926,
-0.0009296745993196964,
0.00806552916765213,
0.01198572851717472,
0.014737343415617943,
-0.016852349042892456,
-0.0335773229598999,
-0.009882006794214249,
0.003415261395275593,
0.00042658625170588493,
-0.02626815438270569,
0.015313804149627686,
0.0021431939676404,
0.01696188375353813,
-0.015545140951871872,
-0.02038281410932541,
-0.007526671048253775,
0.0391077995300293,
-0.010824903845787048,
0.02637328766286373,
-0.007322114426642656,
0.04177703708410263,
0.043389834463596344,
0.003083494957536459,
-0.0064203557558357716,
0.00794883444905281,
0.009503710083663464,
0.010336648672819138,
-0.041272297501564026,
0.025046279653906822,
-0.03130863606929779,
0.011945811100304127,
-0.01499415934085846,
0.02702244557440281,
-0.010446444153785706,
0.003938569221645594,
0.005525818560272455,
-0.0043736775405704975,
-0.003167334944009781,
-0.011065863072872162,
0.025108229368925095,
0.012943834066390991,
-0.009270322509109974,
0.0069656274281442165,
0.02174273692071438,
0.006590304896235466,
-0.0039223493076860905,
-0.0076935444958508015,
-0.08136731386184692,
-0.010367367416620255,
-0.019588911905884743,
0.007637308910489082,
0.0033416440710425377,
0.0031415780540555716,
-0.0010665226727724075,
-0.014060160145163536,
0.00401177816092968,
-0.031210599467158318,
0.0006979331374168396,
-0.00014279247261583805,
-0.0031971591524779797,
0.01808944344520569,
0.008498200215399265,
0.006507826969027519,
0.0042912280187010765,
-0.0005191140808165073,
-0.012876221910119057,
-0.003981765825301409,
0.022046364843845367,
-0.0005185846239328384,
0.022735392674803734,
-0.006250507198274136,
0.02656860649585724,
0.018686819821596146,
0.015632394701242447,
-0.007841184735298157,
0.016232961788773537,
0.011225298047065735,
0.0006498002912849188,
-0.03189487010240555,
0.014757312834262848,
-0.010932698845863342,
0.002135403687134385,
0.009044937789440155,
0.0002422635443508625,
-0.01529393345117569,
-0.019869841635227203,
0.021293621510267258,
-0.018223848193883896,
0.017820844426751137,
0.01716291718184948,
-0.018985338509082794,
0.018898729234933853,
0.008534316904842854,
0.03270342946052551,
-0.005438906140625477,
0.01425680797547102,
0.005548693239688873,
0.00547873554751277,
0.004821592941880226,
0.016451241448521614,
0.012076199054718018,
-0.015579656697809696,
0.009277363307774067,
-0.002006455324590206,
-0.007618460804224014,
-0.014476897194981575,
-0.009073122404515743,
0.010752568021416664,
-0.005031914915889502,
0.009378060698509216,
0.02052384987473488,
-0.0181396696716547,
0.0038068199064582586,
0.027759108692407608,
-0.013196196407079697,
-0.005272242706269026,
0.005127261392772198,
0.003146236762404442,
-0.011252939701080322,
0.004300624132156372,
-0.009158717468380928,
0.01393991056829691,
-0.006915229372680187,
-0.009123937226831913,
-0.01643061265349388,
-0.0116093959659338,
-0.0025745490565896034,
-0.03575630486011505,
0.0015342301921918988,
-0.014729578047990799,
-0.007350457366555929,
-0.019455255940556526,
-0.01010479312390089,
0.011660697869956493,
0.031839318573474884,
0.007313416339457035,
-0.01568009704351425,
0.0022479360923171043,
0.04090458154678345,
-0.02746451459825039,
0.010624222457408905,
0.0021331727039068937,
-0.010278232395648956,
-0.01169769000262022,
-0.01379084587097168,
0.019324887543916702,
0.009528301656246185,
-0.018104998394846916,
0.014127012342214584,
-0.013639816083014011,
-0.009657809510827065,
0.006452532950788736,
0.015985427424311638,
0.023423917591571808,
-0.0004564255941659212,
-0.004967262968420982,
0.0003870034124702215,
-0.003784643718972802,
-0.009245984256267548,
-0.0011715696891769767,
0.030944328755140305,
0.007705572992563248,
0.00801100768148899,
-0.008004935458302498,
-0.0023517014924436808,
0.07155366241931915,
-0.008429191075265408,
0.001823432743549347,
-0.011281922459602356,
0.020621757954359055,
-0.0510893389582634,
-0.0015956471906974912,
0.0006143981590867043,
-0.004426935221999884,
-0.006237042136490345,
0.01455874927341938,
-0.012185842730104923,
0.002375449985265732,
0.005776434671133757,
-0.04620681703090668,
0.0026421514339745045,
-0.030796624720096588,
0.0007810480892658234,
0.0374252051115036,
0.013043530285358429,
-0.023730367422103882,
0.011656000278890133,
-0.019069524481892586,
-0.022732455283403397,
0.013688481412827969,
-0.01593952812254429,
0.00816820003092289,
-0.014191821217536926,
-0.019760936498641968,
0.0030095153488218784,
-0.014760124497115612,
0.021695692092180252,
-0.0036105280742049217,
-0.005674934014678001,
0.006744000595062971,
-0.014685004949569702,
0.024812698364257812,
0.007357906084507704,
0.0041919611394405365,
-0.01209629513323307,
-0.007563818711787462,
-0.012895750813186169,
0.00993927102535963,
0.01370974536985159,
-0.02147510088980198,
-0.01847631111741066,
0.020303651690483093,
-0.007282205391675234,
-0.008433662354946136,
-0.00297342287376523,
-0.006708741653710604,
-0.0021714267786592245,
0.011776217259466648,
0.05333799868822098,
-0.026211105287075043,
-0.028103822842240334,
0.0032384770456701517,
-0.011018626391887665,
-0.009612901136279106,
-0.017433540895581245,
-0.0107949860394001,
-0.021569974720478058,
0.02582838386297226,
-0.00693884864449501,
-0.0013092586304992437,
-0.013576650992035866,
-0.028385888785123825,
0.011339791119098663,
0.010507138445973396,
-0.018119879066944122,
0.023003023117780685,
-0.009702663868665695,
0.0007999995723366737,
0.005628284066915512,
-0.016169555485248566,
-0.001330031082034111,
-0.006109287962317467,
-0.035761117935180664,
0.01187938079237938,
-0.03705154359340668,
-0.037043940275907516,
-0.006102204788476229,
-0.003305767197161913,
-0.012470550835132599,
-0.011095025576651096,
0.009805177338421345,
-0.0006117261946201324,
-0.07495860755443573,
-0.005031796637922525,
-0.01523397583514452,
-0.008589042350649834,
0.02108798548579216,
-0.01389144267886877,
-0.02098383940756321,
0.008338743820786476,
-0.015854477882385254,
0.001483486033976078,
0.014725526794791222,
-0.021402711048722267,
0.02058710902929306,
-0.023890173062682152,
0.013668201863765717,
0.01585235446691513,
-0.02914881706237793,
0.00515334028750658,
-0.03638337180018425,
0.0019573350436985493,
0.013361241668462753,
-0.03109784796833992,
-0.03444406017661095,
-0.0023336855228990316,
-0.0006876245606690645,
-0.08033870160579681,
-0.015421235002577305,
0.01888006553053856,
-0.005563226994127035,
-0.002680370816960931,
-0.006207997910678387,
0.006000828929245472,
-0.02014913409948349,
0.002021243330091238,
-0.018032681196928024,
0.00923339556902647,
-0.004011119715869427,
0.015210012905299664,
-0.02211807668209076,
0.013415459543466568,
-0.009179635904729366,
0.027290742844343185,
0.011812403798103333,
-0.014367964118719101,
-0.011305201798677444,
0.0026118550449609756,
0.0003288215957581997,
-0.01042706985026598,
-0.014633656479418278,
-0.010410172864794731,
0.013789533637464046,
-0.01918560266494751,
0.014591502025723457,
0.00784282386302948,
0.018123844638466835,
-0.01161440834403038,
-0.00777870137244463,
-0.020234782248735428,
0.007633053697645664,
-0.014391738921403885,
-0.011062859557569027,
0.0028724903240799904,
-0.009670231491327286,
0.018578719347715378,
-0.020072132349014282,
-0.00009697373025119305,
-0.011854948475956917,
0.0012657843763008714,
0.015167090110480785,
-0.008832057937979698,
0.022601917386054993,
0.006208442617207766,
-0.008978331461548805,
0.004390500020235777,
-0.023051820695400238,
0.011435573920607567,
0.0038965591229498386,
0.0030452758073806763,
-0.014856571331620216,
-0.029982876032590866,
0.025803107768297195,
0.004438933450728655,
0.011019553057849407,
0.005353138782083988,
0.01693483255803585,
-0.006159425713121891,
0.01686745136976242,
0.001978422747924924,
0.07154354453086853,
-0.004880008287727833,
0.0033664475195109844,
-0.006559586152434349,
-0.0029871417209506035,
0.005216909106820822,
0.01584838703274727,
0.008112389594316483,
0.02373240888118744,
-0.008444576524198055,
0.013372866436839104,
-0.011441363021731377,
-0.028698280453681946,
0.014272354543209076,
0.00935037899762392,
-0.025358034297823906,
0.002569679170846939,
-0.018920980393886566,
-0.016713201999664307,
-0.004040620755404234,
-0.004117594100534916,
-0.00966556929051876,
-0.03954221308231354,
0.02671663463115692,
0.02603800594806671,
-0.013098370283842087,
-0.007243202067911625,
0.021541932597756386,
-0.00936183426529169,
0.024210108444094658,
-0.0020529860630631447,
-0.008234832435846329,
-0.0034406299237161875,
0.005097542889416218,
-0.0005212272517383099,
0.02405579760670662,
-0.0068526240065693855,
0.0023601651191711426,
-0.013819899410009384,
0.04612955451011658,
0.014957929961383343,
-0.0032880462240427732,
-0.001411103061400354,
-0.0014845388941466808,
0.027396701276302338,
-0.02253030240535736,
-0.012100287713110447,
0.0026042303070425987,
-0.024039477109909058,
0.00551341287791729,
-0.01918892376124859,
0.003881462151184678,
-0.0031553800217807293,
0.013740185648202896,
0.0037511084228754044,
-0.0345144122838974,
-0.025192290544509888,
0.02608170360326767,
-0.027064846828579903,
-0.013785903342068195,
0.010165954008698463,
-0.019593164324760437,
0.006817878223955631,
-0.02335200086236,
0.028682421892881393,
-0.002820426132529974,
0.0045241303741931915,
-0.00927664153277874,
0.01935199648141861,
0.017511095851659775,
0.007056112866848707,
-0.0027071754448115826,
0.006898030638694763,
-0.0014028954319655895,
0.026080846786499023,
0.0023752860724925995,
0.008048665709793568,
0.016960082575678825,
0.018025370314717293,
0.02168387919664383,
-0.01328345201909542,
-0.0020327074453234673,
0.01024610921740532,
-0.041588395833969116,
0.024506686255335808,
0.018827958032488823,
0.005186871159821749,
-0.009443697519600391,
-0.006214029621332884,
0.0028279279358685017,
-0.01262254174798727,
-0.010008390992879868,
-0.0015637468313798308,
0.0028505597729235888,
0.007048709783703089,
0.03588965907692909,
0.015824614092707634,
0.004519995767623186,
0.014273039065301418,
0.0037253270857036114,
0.011694518849253654,
-0.018229903653264046,
-0.007014917209744453,
-0.0013199057430028915,
0.0004854468861594796,
0.002603752538561821,
0.03178538382053375,
-0.005790340714156628,
0.016638197004795074,
-0.005537049379199743,
0.005857507698237896,
-0.05581684410572052,
0.021300749853253365,
0.011387089267373085,
0.01604105904698372,
-0.007121863774955273,
0.008679158985614777,
0.025332655757665634,
0.01041751354932785,
-0.011111992411315441,
-0.0014757830649614334,
-0.005809764377772808,
-0.005744035821408033,
0.04010798782110214,
0.01034755539149046,
-0.00822427961975336,
-0.01349886879324913,
0.015382928773760796,
-0.004784320946782827,
-0.014590461738407612,
0.02130122110247612,
-0.028279617428779602,
0.008673427626490593,
0.02911652997136116,
-0.012462589889764786,
0.007305617444217205,
0.0029468024149537086,
0.009358168579638004,
-0.0030792630277574062,
0.0231817364692688,
0.015314913354814053,
-0.004822855349630117,
0.0025863356422632933,
-0.0029836343601346016,
0.0077492855489254,
0.0033116103149950504,
0.026669342070817947,
0.046522900462150574,
0.016284026205539703,
-0.01400071382522583,
-0.01846335083246231,
0.02150750160217285,
-0.0005895961076021194,
-0.004539202898740768,
0.01158255897462368,
0.0076734283939003944,
-0.000005871639586985111,
-0.003171947319060564,
-0.006976098287850618,
-0.0051947287283837795,
-0.004721230827271938,
-0.017182614654302597,
0.013940293341875076,
0.005701277405023575,
-0.014123200438916683,
0.03818751499056816,
-0.03403051570057869,
-0.0015045050531625748,
-0.022555839270353317,
-0.04685160517692566,
0.018516628071665764,
0.0017664252081885934,
-0.006055655889213085,
0.023177452385425568,
-0.03157736361026764,
-0.013786738738417625,
-0.01114448718726635,
-0.0004679759731516242,
0.01153513789176941,
0.030130136758089066,
0.008280977606773376,
-0.012028995901346207,
0.019505713135004044,
-0.007575103547424078,
0.006544495467096567,
0.0008652489632368088,
0.0027733726892620325,
0.0060294740833342075,
-0.0010741334408521652,
-0.02879040688276291,
-0.02436143159866333,
-0.0012853117659687996,
0.002367570297792554,
0.007251659873872995,
-0.021485473960638046,
-0.024638308212161064,
0.005438215099275112,
-0.02041718363761902,
-0.002764007542282343,
0.012515638023614883,
0.009591186419129372,
-0.015740513801574707
] | [
0.5839071869850159,
0.012732813134789467,
-0.1822248250246048,
0.06748978048563004,
0.3970179259777069,
0.6399363279342651,
0.09938746690750122,
0.4023512601852417,
-0.2984422445297241,
-0.5181624293327332,
0.47753360867500305,
0.46585047245025635,
-0.110801562666893,
-0.03582877665758133,
-0.5055844187736511,
0.39822906255722046,
0.523957371711731,
0.5892167687416077,
-0.3715294301509857,
-0.6030179262161255,
-0.4166596829891205,
-0.27844691276550293,
0.857606828212738,
-0.015309932641685009,
0.0666663721203804,
-0.11781448870897293,
0.5833778977394104,
0.12836234271526337,
0.27836334705352783,
-0.003605012083426118,
-0.25370049476623535,
0.9396846294403076,
0.22748170793056488,
-0.06201735883951187,
0.2973906099796295,
-0.33125191926956177,
0.03629831224679947,
-0.21337983012199402,
0.1817793846130371,
0.2926120162010193,
-0.08295810222625732,
-0.11754489690065384,
-0.24973182380199432,
0.7178598046302795,
-0.22901014983654022,
-0.19499632716178894,
-1.4660346508026123,
0.6520987749099731,
0.07059093564748764,
-0.37258028984069824,
0.4253948926925659,
0.01925327070057392,
0.12685218453407288,
0.4709949791431427,
0.6135739684104919,
0.023017648607492447,
-1.0579791069030762,
-0.45303553342819214,
0.5704289674758911,
-0.10762172192335129,
-0.21938900649547577,
-0.0670691579580307,
-0.45119452476501465,
-0.20445570349693298,
-0.1822175681591034,
0.3754287362098694,
0.2565842270851135,
-0.17337989807128906,
-0.47339919209480286,
0.004222289193421602,
-0.05525406077504158,
-0.22898633778095245,
-0.2647125720977783,
-0.09467791765928268,
0.13193659484386444,
0.4799337685108185,
-0.31684038043022156,
-0.09502439200878143,
0.5591208338737488,
-0.4904480278491974,
0.180908665060997,
-0.1370893120765686,
0.6104761362075806,
-0.024414386600255966,
0.27443844079971313,
0.27991560101509094,
0.037075892090797424,
0.7161527276039124,
-0.16589277982711792,
0.052557773888111115,
-0.26244819164276123,
-0.11942709237337112,
0.3820749819278717,
0.8294632434844971,
-0.2536849081516266,
0.5903215408325195,
0.030354641377925873,
0.005973705090582371,
0.37430325150489807,
0.1384267956018448,
-0.24414503574371338,
-0.1551440805196762,
0.06368163973093033,
-0.3864906430244446,
-0.45008403062820435,
-0.15720929205417633,
0.28999143838882446,
0.10034742206335068,
-0.3957410156726837,
-0.03262922540307045,
-0.8075854778289795,
0.10750462114810944,
-0.19226200878620148,
-0.374223530292511,
-0.04947972670197487,
0.14964067935943604,
-0.07729269564151764,
-0.520298182964325,
-0.3352835178375244,
-0.20547723770141602,
-0.46401163935661316,
0.7698162198066711,
-0.2490989863872528,
0.4015518128871918,
0.09807953983545303,
0.5288590788841248,
0.05807449296116829,
0.20523716509342194,
0.5263542532920837,
0.43863749504089355,
0.42572492361068726,
0.6334354281425476,
-0.3799631893634796,
0.09497232735157013,
0.3105587661266327,
-0.1495245099067688,
0.14730429649353027,
0.3149283230304718,
0.8951348066329956,
0.11043323576450348,
-0.375371515750885,
-0.6979013085365295,
-0.05706989765167236,
0.1975342035293579,
0.12642917037010193,
-0.5367651581764221,
-0.20934465527534485,
-0.16861014068126678,
0.035807233303785324,
0.009217209182679653,
0.39228132367134094,
-0.42344096302986145,
-0.4912833571434021,
-0.3118601441383362,
-0.1640307903289795,
-0.19523398578166962,
-0.018095938488841057,
-0.299007773399353,
-0.34342488646507263,
0.4146215319633484,
0.15671710669994354,
0.11391569674015045,
-0.6978907585144043,
-0.216714546084404,
0.49382665753364563,
-0.3195840120315552,
0.2896501123905182,
0.07178276777267456,
-0.3459826111793518,
0.35376104712486267,
-0.47768375277519226,
0.10357603430747986,
-0.015625273808836937,
-0.5805509090423584,
0.0953577533364296,
0.28866806626319885,
0.4248228371143341,
-0.18117713928222656,
0.2803352475166321,
-0.1433894783258438,
-0.7140935659408569,
0.1295662373304367,
0.36484548449516296,
-0.40092751383781433,
0.5048809051513672,
0.21641376614570618,
0.2885885238647461,
-0.2534019351005554,
-0.38346463441848755,
-0.9281127452850342,
-0.18835332989692688,
-0.5267122983932495,
1.0468958616256714,
-0.5616999268531799,
1.1288541555404663,
-0.5840747356414795,
-0.01329929567873478,
0.8394344449043274,
0.504416823387146,
0.016449332237243652,
-0.14644980430603027,
-0.38010644912719727,
0.6782259941101074,
-0.22760502994060516,
-0.7416737079620361,
0.03133898228406906,
-0.14804446697235107,
-0.3232423663139343,
0.3107767701148987,
-0.22335635125637054,
0.6325171589851379,
-0.13580618798732758,
-0.3168313205242157,
0.000107297528302297,
-0.03238315507769585,
0.02823605202138424,
-0.04732561111450195,
0.1842876821756363,
-0.48954570293426514,
-0.01005959790199995,
0.15337832272052765,
-0.8009470105171204,
0.5290307402610779,
0.27751895785331726,
0.022395538166165352,
0.670478105545044,
0.6401121616363525,
0.0501684695482254,
1.0221776962280273,
-0.38458091020584106,
0.31900733709335327,
-0.3460081219673157,
0.16256535053253174,
-0.5702125430107117,
-0.058164481073617935,
0.3164130449295044,
-0.10869304835796356,
-0.0320761539041996,
-0.011283798143267632,
0.08321487903594971,
-0.5622159242630005,
0.5749448537826538,
-1.1526211500167847,
-0.15238259732723236,
-0.16413551568984985,
-0.44967392086982727,
-0.2920074164867401,
0.287054181098938,
-1.5392422676086426,
0.0457647480070591,
-0.18907327950000763,
0.09652791172266006,
0.13614794611930847,
-0.7465081810951233,
-0.49584105610847473,
-0.0018502279417589307,
-0.16403897106647491,
-0.38317427039146423,
0.4132274389266968,
-0.3562139570713043,
-0.09879601001739502,
0.29190728068351746,
0.39584290981292725,
0.3253931701183319,
-0.10443682968616486,
-0.3373330533504486,
-0.6424793601036072,
-0.3997102975845337,
0.8147035837173462,
0.464164674282074,
1.0660837888717651,
0.023324649780988693,
-1.0650577545166016,
-0.0210293997079134,
0.3728947639465332,
-0.7201098203659058,
-0.12400975078344345,
1.0465381145477295,
-0.7660573720932007,
-0.08818138390779495,
-0.2912040650844574,
0.792204737663269,
0.7736759185791016,
-0.009402135387063026,
-0.37690702080726624,
-0.16799643635749817,
-0.010842358693480492,
-0.333575963973999,
-0.1825346052646637,
-0.41151881217956543,
-0.43268126249313354,
0.7865428328514099,
-0.5236467123031616,
-0.2060743272304535,
0.6452648043632507,
0.343890517950058,
-0.2509716749191284,
0.3576733469963074,
0.5281241536140442,
-0.1554582715034485,
0.28984081745147705,
0.5975576639175415,
0.3140419125556946,
-0.019333424046635628,
-0.12286005914211273,
0.4412253499031067,
-0.30198538303375244,
0.09071415662765503,
-5.605010986328125,
0.52488112449646,
-0.0035361596383154392,
-0.47497743368148804,
-0.05968303978443146,
-0.06397219002246857,
1.1929351091384888,
0.046786095947027206,
0.37319692969322205,
0.1840353161096573,
0.2469761222600937,
0.3855752646923065,
0.07574737071990967,
0.041996173560619354,
-0.11705252528190613,
-0.421771764755249,
0.016724370419979095,
-0.4051766097545624,
0.5954891443252563,
0.35865452885627747,
0.05988462641835213,
-0.22403813898563385,
-0.14118443429470062,
0.5649981498718262,
0.312738835811615,
0.07196450978517532,
-0.798687219619751,
-0.11715979874134064,
-0.22463542222976685,
-0.8938966989517212,
0.06349676102399826,
-0.7550232410430908,
0.36564865708351135,
-0.42720070481300354,
0.30299055576324463,
0.16189385950565338,
0.04996322840452194,
0.1666523963212967,
-0.006239014677703381,
-0.39023828506469727,
0.1336795538663864,
0.1854572594165802,
-0.08149771392345428,
-0.3371106684207916,
0.5672167539596558,
0.41982632875442505,
0.11767436563968658,
0.08106450736522675,
-0.2708316147327423,
1.1581794023513794,
0.13555589318275452,
-0.26221251487731934,
-0.19697128236293793,
0.5467364192008972,
0.5055108070373535,
0.32107847929000854,
-0.04340172931551933,
-0.005367887206375599,
-0.35934337973594666,
0.26450374722480774,
-0.10117404907941818,
0.01535622775554657,
-0.15561793744564056,
-0.5214754939079285,
-0.033057793974876404,
-0.11921185255050659,
-1.0279872417449951,
-0.14445582032203674,
0.4025576412677765,
-0.23697416484355927,
-0.24111799895763397,
-0.1118779331445694,
0.2269355058670044,
-0.8390640616416931,
0.7132443189620972,
-0.4737793505191803,
0.08858362585306168,
-0.0438208132982254,
0.11860904842615128,
-0.5464794039726257,
0.27315565943717957,
-0.30293089151382446,
-0.008803784847259521,
0.026406479999423027,
0.3712981641292572,
-0.19432951509952545,
-0.40323081612586975,
-0.005961012560874224,
-0.36952903866767883,
-0.024188680574297905,
0.3880424499511719,
-0.28295788168907166,
-0.4097210764884949,
0.1717282235622406,
0.6099117398262024,
0.6465578675270081,
0.786882758140564,
0.7035650014877319,
0.27175143361091614,
0.225822314620018,
0.6001711487770081,
-0.42660340666770935,
-0.55572509765625,
-0.951894223690033,
-0.18808448314666748,
0.08788086473941803,
-0.175835520029068,
0.22433555126190186,
0.46303102374076843,
-1.1158161163330078,
0.1622285097837448,
-0.2223367989063263,
-0.7568201422691345,
-0.6391515135765076,
0.5119600296020508,
-0.3545934557914734,
0.08092791587114334,
-0.16527502238750458,
0.8611299991607666,
-0.32060930132865906,
0.15030601620674133,
0.3514142632484436,
-0.54662024974823,
0.27342674136161804,
0.355551540851593,
-0.64776211977005,
0.3493231236934662,
0.698605477809906,
-0.9553518295288086,
-0.20806331932544708,
0.030405161902308464,
0.3677661418914795,
-0.3636418879032135,
-0.08461493253707886,
-0.13333745300769806,
-0.27036675810813904,
-0.44186320900917053,
0.36947396397590637,
0.5592300295829773,
0.11370401829481125,
0.1942034512758255,
-0.147697314620018,
-0.20421810448169708,
0.11564234644174576,
0.48236018419265747,
-0.016743190586566925,
-0.08777687698602676,
0.03330573812127113,
-0.3725148141384125,
-0.4629940986633301,
0.24618706107139587,
0.15231731534004211,
0.4778951108455658,
0.1025879755616188,
-0.33370015025138855,
0.4713183641433716,
0.41177868843078613,
0.2519233822822571,
-0.2092256247997284,
-1.1181634664535522,
0.20818056166172028,
-0.1532231867313385,
-0.8460839986801147,
-0.0925234854221344,
-0.05920619145035744,
-0.5356236100196838,
-0.01453518494963646,
-0.8493754267692566,
0.13187092542648315,
0.25859078764915466,
-0.1208823025226593,
-0.29366013407707214,
-0.122775599360466,
0.026885082945227623,
-0.003954168874770403,
-0.4357844889163971,
-0.5757061839103699,
-0.158454030752182,
-0.29674139618873596,
-0.19010630249977112,
0.07372311502695084,
0.08478289842605591,
-0.007716436870396137,
-0.02111417055130005,
0.6806763410568237,
0.8115149140357971,
0.17932701110839844,
0.26602107286453247,
-0.5711137056350708,
-0.15131324529647827,
0.36543625593185425,
-0.26152297854423523,
0.3827109932899475,
-0.27360793948173523,
0.13616237044334412,
0.1765296310186386,
0.20907317101955414,
0.7199034094810486,
0.028360333293676376,
0.12017875909805298,
-0.2656942307949066,
0.4823557138442993,
-0.3416527509689331,
0.401233434677124,
0.7962507605552673,
-0.13804304599761963,
-0.11432085931301117,
-0.19617809355258942,
-0.549126386642456,
-0.3414403200149536,
-0.37024685740470886,
-0.4900282919406891,
-0.3428499400615692,
0.25514477491378784,
-0.28443798422813416,
-0.17077435553073883,
0.24219100177288055,
-0.3129790425300598,
-0.23197956383228302,
0.4210045337677002,
0.5919623970985413,
0.057663701474666595,
-0.12475891411304474,
0.10358511656522751,
-0.19414854049682617,
0.23139579594135284,
0.5923232436180115,
-0.5454900860786438,
0.540854811668396,
0.03505396097898483,
-0.263344943523407,
0.012841017916798592,
0.1892145723104477,
0.06664655357599258,
-0.6366440653800964,
-0.1556997001171112,
0.0008333571604453027,
0.30093613266944885,
0.3593725860118866,
0.6387618184089661,
0.3557724058628082,
0.492456316947937,
-0.23423044383525848,
-0.2832860052585602,
-0.3425164520740509,
0.17706158757209778,
0.28314173221588135,
-0.5573908686637878,
-0.377883642911911,
0.35156387090682983,
0.30009883642196655,
-0.2948172092437744,
0.26434266567230225,
0.3636133372783661,
0.5135164856910706,
0.005789455492049456,
-0.5589607954025269,
-0.6362898349761963,
0.029217427596449852,
0.4219410717487335,
-0.18064098060131073,
-0.49648818373680115,
0.16975189745426178,
0.063594289124012,
0.450789213180542,
-0.012053512036800385,
-0.23637357354164124,
-0.3796926736831665,
0.41612881422042847,
-0.26931992173194885,
-0.03529640659689903,
-0.22319179773330688,
0.8147751688957214,
0.2241600900888443,
-0.07379566878080368,
0.14603695273399353,
-0.5734798908233643,
-0.47256457805633545,
-0.4545648396015167,
0.1659768670797348,
-0.2720768451690674,
-0.5776180028915405,
0.2895045280456543,
-0.4201577603816986,
0.08719630539417267,
-0.5476850867271423,
0.19031867384910583,
-0.591154932975769,
-0.18334384262561798,
-0.403842568397522,
-0.3792186677455902,
0.0664515420794487,
-0.5750872492790222,
-0.42997291684150696,
0.3843446373939514,
0.2596971392631531,
0.29068872332572937,
0.4396892189979553,
0.4065591096878052,
-0.11173048615455627,
-0.15723371505737305,
0.37537112832069397,
-0.0005737811443395913,
-0.32743337750434875,
0.2574613094329834,
0.04994449019432068,
-0.36657124757766724,
-0.1179589033126831,
-0.30177056789398193,
0.5370519161224365,
-0.06348768621683121,
-0.17655761539936066,
0.43763309717178345,
0.1961761862039566,
-0.08079065382480621,
0.1455000638961792,
-0.3268197774887085,
-0.6683031320571899,
0.5990573167800903,
0.19457599520683289,
0.47942212224006653,
1.072283148765564,
0.762488603591919,
0.14542484283447266,
-0.23139804601669312,
0.5046888589859009,
0.3854404091835022,
0.3550857603549957,
0.20357456803321838,
0.4947912395000458,
0.3363860845565796,
0.7403839826583862,
-0.09505819529294968,
0.46079766750335693,
0.3655332624912262,
0.24732960760593414,
0.1726253777742386,
-0.5887575149536133,
-0.15789830684661865,
0.17060823738574982,
0.8504800796508789,
-0.015598393976688385,
-0.1455661654472351,
-0.010165107436478138,
0.40814894437789917,
0.39372098445892334,
-0.20450130105018616,
-0.16123515367507935,
0.08148310333490372,
0.10021738708019257,
0.12402905523777008,
-1.2200891971588135,
-0.6343639492988586,
-0.3949653208255768,
-0.3819389343261719,
0.2584793269634247,
0.00048118759877979755,
-0.7091764211654663,
-1.1209063529968262,
0.08831529319286346,
-0.3584481477737427,
0.07694918662309647,
-0.06080259382724762,
0.43447041511535645,
0.042576275765895844,
-0.07035855203866959,
0.27763983607292175,
0.5694712400436401,
0.5098854899406433,
-0.1172775998711586,
0.11687549203634262,
-0.1866583526134491,
-0.16328275203704834,
0.15862061083316803,
0.3102962374687195,
-0.08717246353626251,
0.004053968004882336,
0.21535393595695496,
-0.20178741216659546,
0.061333801597356796,
-0.6583498120307922,
0.3788202404975891,
-0.09681142121553421,
-0.20626801252365112,
-0.31241390109062195,
-0.42864906787872314,
-0.20717990398406982,
-0.0969761312007904,
0.04631144925951958,
0.005991505924612284,
0.35939809679985046,
-0.591546893119812,
0.45936134457588196,
0.4713526964187622,
-0.4609774947166443,
-0.20303410291671753,
0.01047470048069954,
0.303305983543396,
0.06777185201644897,
0.3451332747936249,
-0.44540873169898987,
0.07014717906713486,
-0.3783540427684784,
0.33574599027633667,
-0.2930150330066681,
0.46878349781036377,
-0.20391887426376343,
-0.3958846926689148,
-0.5920956134796143,
-0.26119866967201233,
1.1037307977676392,
0.6080700755119324,
-0.03476160019636154,
0.38334977626800537,
0.3581531345844269,
0.009758510626852512,
0.42086851596832275,
-0.03700944781303406,
-0.6798938512802124,
-0.5096610188484192,
-0.025168852880597115,
-0.6884072422981262,
1.0879157781600952,
-0.7884858250617981,
-0.0589614138007164,
-0.08884324133396149,
0.46404677629470825,
0.4552057385444641,
-0.12692825496196747,
0.3603518009185791,
-0.7522085309028625,
0.04715946316719055,
-0.5946959853172302,
0.5436577200889587,
-0.43321576714515686,
0.2778041660785675,
0.21947096288204193,
0.07356414198875427,
0.30600976943969727,
-0.19189102947711945,
-0.12001806497573853,
-0.4695538282394409,
0.36585649847984314,
0.08632918447256088,
0.3229212164878845,
0.4817419648170471,
-0.02877161279320717,
-0.27619248628616333,
-0.9591579437255859,
0.13262642920017242,
-0.5549527406692505,
-0.6688639521598816,
-0.26325100660324097,
0.40189412236213684,
-0.23558840155601501,
-0.4102405905723572,
-0.03394058719277382,
-0.50235915184021,
-0.38141870498657227,
-0.5640949606895447
] |
The ART-adherence club model described here provides patient-friendly access to antiretroviral therapy (ART) for clinically stable patients. It reduces the burden that stable patients place on healthcare facilities, increasing clinical human resources for new patients, and those clinically unstable and at risk of failing treatment. In the model, 30 patients are allocated to an ART club. The group meets either at a facility or community venue for less than an hour every 2 months. Group meetings are facilitated by a lay club facilitator who provides a quick clinical assessment, referral where necessary, and dispenses pre-packed ART. From January 2011 to December 2012, after adoption for phased rollout by the Western Cape Government, more than 600 ART clubs were established in Cape Town, providing ART care to over 16 000 patients. This extensive, rapid rollout demonstrates active buy-in from patients and facility staff. South Africa should consider a similar model for national rollout. | [
0.012987567111849785,
0.02273697406053543,
-0.01772061362862587,
0.01591390185058117,
0.001817798474803567,
-0.009897883050143719,
0.009065471589565277,
0.0032150130718946457,
-0.012406162917613983,
-0.007950722239911556,
-0.009856303222477436,
0.010470991022884846,
0.0009245944675058126,
0.02432471513748169,
-0.012270487844944,
-0.01669258624315262,
-0.014253176748752594,
0.000355070224031806,
0.0074355462566018105,
0.024295739829540253,
0.0004440629854798317,
-0.018629062920808792,
0.009197819977998734,
0.011379322037100792,
0.0018291340675204992,
-0.003622607793658972,
0.005944203585386276,
-0.01970904879271984,
-0.01234002411365509,
-0.005144585855305195,
-0.005180240608751774,
0.01486936304718256,
-0.0008028382435441017,
0.006777511909604073,
0.0014672869583591819,
-0.014175514690577984,
-0.004905985668301582,
0.021514438092708588,
0.009741205722093582,
-0.0048214104026556015,
0.005398222245275974,
-0.003211517818272114,
0.004733417183160782,
0.00659739226102829,
-0.009003464132547379,
-0.0027069421485066414,
-0.008097540587186813,
0.008434386923909187,
-0.01632959023118019,
0.013420676812529564,
-0.01333296112716198,
0.021556146442890167,
-0.012020047754049301,
-0.018059393391013145,
-0.005497397854924202,
-0.018231680616736412,
0.01708795875310898,
-0.02608644776046276,
0.0008594247046858072,
0.0015009701019153,
0.03599148616194725,
0.027282893657684326,
0.025005996227264404,
-0.0023558202665299177,
0.005553879775106907,
-0.06701674312353134,
0.01325930468738079,
0.015984443947672844,
-0.0059339855797588825,
0.008315588347613811,
-0.006810138933360577,
0.01048640813678503,
0.020919593051075935,
0.007503224071115255,
-0.017406055703759193,
0.010132919065654278,
0.016431985422968864,
0.016711406409740448,
0.05640222504734993,
0.013601191341876984,
-0.011978831142187119,
-0.006322215776890516,
-0.004158474504947662,
0.015202264301478863,
-0.0033976174890995026,
-0.009970923885703087,
-0.009392913430929184,
-0.012279074639081955,
0.0038467124104499817,
0.0008228239603340626,
0.003081653732806444,
-0.014302820898592472,
-0.007984918542206287,
-0.012253228574991226,
-0.009175791405141354,
0.01697339303791523,
0.010320691391825676,
-0.0044069113209843636,
0.030568767338991165,
0.016679950058460236,
-0.017395220696926117,
0.022932253777980804,
0.019939998164772987,
0.023090898990631104,
0.006865933537483215,
0.009277526289224625,
-0.012656059116125107,
0.006977449171245098,
-0.008925302885472775,
0.004111056216061115,
0.004287160933017731,
0.004929038695991039,
0.03727298229932785,
0.018072472885251045,
-0.01503673754632473,
-0.01790628582239151,
0.035130664706230164,
0.019477950409054756,
0.01201456319540739,
-0.010169968008995056,
0.010905379429459572,
-0.007961100898683071,
0.008066894486546516,
-0.006210427265614271,
0.004280054941773415,
0.023296482861042023,
0.008870504796504974,
-0.010772746056318283,
0.002458101138472557,
0.016866661608219147,
-0.011750652454793453,
-0.0004976780619472265,
0.00993301160633564,
0.012966446578502655,
-0.021054405719041824,
0.0020939442329108715,
0.001108310418203473,
0.0035759462043642998,
0.0037070894613862038,
0.003613913431763649,
0.032616451382637024,
0.011659881100058556,
0.0004508751444518566,
0.00658296886831522,
-0.00027478625997900963,
0.003251115558668971,
0.008651885204017162,
0.018808159977197647,
-0.0019867620430886745,
0.010601277463138103,
0.012559900991618633,
-0.0017265970818698406,
-0.013347174972295761,
-0.016079727560281754,
-0.04127909243106842,
0.02117934077978134,
-0.0032855067402124405,
-0.012986414134502411,
-0.006438548676669598,
0.00483988830819726,
0.009831922128796577,
0.02798643708229065,
0.01353466883301735,
0.006986318156123161,
-0.0069770123809576035,
0.017568513751029968,
0.001141975400969386,
-0.003397368360310793,
-0.02502194419503212,
0.0035949875600636005,
-0.010631676763296127,
-0.004830889403820038,
-0.002154341898858547,
0.0049439179711043835,
0.015809517353773117,
-0.006787235848605633,
0.008084028959274292,
0.010243857279419899,
-0.006427176296710968,
0.06709672510623932,
0.0181313157081604,
0.011932827532291412,
0.014077503234148026,
0.003886245423927903,
0.016390163451433182,
0.011453788727521896,
-0.028641320765018463,
-0.00911853276193142,
0.013063613325357437,
-0.009798670187592506,
0.011251158080995083,
0.003711225464940071,
0.02159266546368599,
0.007933532819151878,
-0.003644475946202874,
0.004592725541442633,
-0.009591366164386272,
-0.007309785578399897,
0.006784604396671057,
-0.027120567858219147,
-0.017139330506324768,
-0.008810412138700485,
0.019127342849969864,
-0.008116140030324459,
0.0038944666739553213,
0.003502602456137538,
0.013241598382592201,
-0.011202195659279823,
-0.011784013360738754,
0.020823229104280472,
0.0439390167593956,
-0.022588839754462242,
-0.011975118890404701,
-0.0022270455956459045,
0.009906494989991188,
-0.011731150560081005,
-0.009172704070806503,
-0.009139500558376312,
-0.026743721216917038,
-0.010100070387125015,
-0.011168123222887516,
0.0030034915544092655,
-0.04982151463627815,
0.015000533312559128,
0.015455645509064198,
0.010972484014928341,
0.009315314702689648,
0.011817403137683868,
0.0028169327415525913,
0.0030300263315439224,
0.02012750692665577,
-0.007460442837327719,
-0.009843118488788605,
0.007005572319030762,
-0.017393628135323524,
0.0027470386121422052,
0.011099052615463734,
-0.028930775821208954,
0.021426241844892502,
-0.004424733575433493,
0.0029948875308036804,
-0.023045755922794342,
-0.05531886965036392,
0.005077875219285488,
0.013486562296748161,
-0.015383566729724407,
0.002699771896004677,
-0.029482029378414154,
-0.013443609699606895,
-0.029840590432286263,
0.005774898454546928,
-0.03645150363445282,
-0.009340912103652954,
0.010516972281038761,
-0.009858456440269947,
-0.008153954520821571,
0.03786567971110344,
-0.007244262378662825,
0.02220280095934868,
-0.0008957246318459511,
0.009908350184559822,
0.007167287170886993,
-0.00931786373257637,
-0.04284512251615524,
-0.012672127224504948,
0.007758229970932007,
-0.0037869340740144253,
0.027561744675040245,
0.006595403887331486,
-0.028877075761556625,
0.006593429017812014,
-0.010191267356276512,
-0.0053822374902665615,
-0.08165711164474487,
-0.007631015498191118,
-0.003045890014618635,
0.005092530511319637,
0.010936832055449486,
-0.008784477598965168,
-0.004385038278996944,
0.02290256693959236,
-0.0017121518030762672,
0.030286170542240143,
0.021534789353609085,
0.011462817899882793,
-0.013187600299715996,
-0.0026204229798167944,
-0.0023620822466909885,
-0.009282460436224937,
0.0018553012050688267,
0.041782137006521225,
0.005269134882837534,
-0.03488137573003769,
-0.01346398051828146,
0.031935229897499084,
-0.0033921340946108103,
-0.0028563193045556545,
-0.013094350695610046,
0.02855917438864708,
-0.002715594135224819,
0.010648814029991627,
-0.01662653684616089,
0.008495043963193893,
-0.007894983515143394,
-0.015559830702841282,
-0.029082491993904114,
-0.016687819734215736,
0.00413856003433466,
-0.010202075354754925,
-0.03441300615668297,
0.0001866607926785946,
-0.003030898980796337,
-0.014657745137810707,
0.002786620520055294,
0.017407681792974472,
-0.007130554877221584,
0.0017361132195219398,
-0.0052922009490430355,
0.019867997616529465,
0.018115200102329254,
0.03454890847206116,
0.019239140674471855,
-0.020916689187288284,
0.001432978082448244,
-0.010615536943078041,
0.029174135997891426,
0.00851311907172203,
-0.017178941518068314,
-0.013908017426729202,
-0.03346124291419983,
-0.013934118673205376,
-0.014238137751817703,
-0.00817261915653944,
-0.017472589388489723,
0.012649493291974068,
0.01848888024687767,
0.008833067491650581,
-0.005182361695915461,
-0.007417056709527969,
0.00035143294371664524,
-0.038250334560871124,
0.004382038488984108,
0.012857068330049515,
-0.00020037649665027857,
0.007964188233017921,
-0.008955122902989388,
-0.010623296722769737,
-0.002267231233417988,
-0.021382290869951248,
-0.01879921182990074,
0.006780602037906647,
0.002038974314928055,
-0.0010987743735313416,
-0.014254170469939709,
0.0015547265065833926,
-0.005768676288425922,
0.0030319325160235167,
-0.014363816007971764,
0.0028458787128329277,
0.020072482526302338,
-0.000359027530066669,
0.0067409612238407135,
-0.006185740698128939,
0.008951574563980103,
0.017644543200731277,
0.012366190552711487,
0.002360851736739278,
0.0167849063873291,
0.00221681734547019,
0.016708264127373695,
0.004809604026377201,
0.009329177439212799,
0.010556738823652267,
0.021012701094150543,
0.0030035413801670074,
-0.025191163644194603,
-0.016802558675408363,
-0.01293217483907938,
0.010462002828717232,
0.009081067517399788,
0.010565784759819508,
0.0024920273572206497,
-0.01010116282850504,
-0.013064362108707428,
-0.004224707838147879,
-0.01055352482944727,
0.0018825409933924675,
0.013189093209803104,
0.0061846207827329636,
0.01588061824440956,
0.007577033713459969,
0.07247700542211533,
0.0005313067231327295,
0.003389099147170782,
-0.016673995181918144,
-0.013432034291327,
-0.017085079103708267,
-0.01577330008149147,
0.023399706929922104,
0.042625416070222855,
-0.00989636778831482,
0.009933452121913433,
-0.015293100848793983,
0.010801558382809162,
-0.008839796297252178,
-0.037800565361976624,
-0.015636993572115898,
0.006902954075485468,
-0.016116753220558167,
-0.01350579597055912,
0.016646360978484154,
-0.034854259341955185,
-0.0021154775749891996,
-0.017926175147294998,
-0.00006402446888387203,
0.011511895805597305,
0.006242456845939159,
-0.002176211681216955,
-0.013992558233439922,
-0.0027227462269365788,
0.0041759018786251545,
-0.009171292185783386,
-0.023567747324705124,
-0.00553462840616703,
-0.011756950058043003,
0.0367942675948143,
-0.0007926207035779953,
-0.005376865155994892,
0.016133658587932587,
0.033338338136672974,
0.0009273011237382889,
0.025422245264053345,
-0.012379339896142483,
-0.01041258405894041,
0.014252996072173119,
0.007638260722160339,
0.02178851142525673,
-0.0060486700385808945,
-0.009469661861658096,
-0.010211795568466187,
0.02580951154232025,
-0.01845390349626541,
-0.00699404813349247,
0.01263359934091568,
0.002025601454079151,
-0.009714007377624512,
-0.014869732782244682,
-0.001360161229968071,
-0.011045753955841064,
-0.005291080567985773,
-0.02748860791325569,
-0.024215970188379288,
0.007463962770998478,
0.002922165673226118,
0.0019415300339460373,
0.0005247974768280983,
-0.006222199182957411,
0.01979183778166771,
-0.0022600004449486732,
-0.008310597389936447,
0.0006684344261884689,
-0.019134776666760445,
-0.004875576123595238,
-0.018463104963302612,
-0.027510814368724823,
-0.04129379242658615,
-0.0390617698431015,
0.009060533717274666,
0.0239468552172184,
0.04495999589562416,
-0.02456493303179741,
0.013445076532661915,
0.017089737579226494,
0.020212525501847267,
-0.01846066489815712,
0.015459954738616943,
0.02661004289984703,
-0.01751653663814068,
-0.07425501197576523,
0.009859263896942139,
-0.007830768823623657,
-0.01010837685316801,
-0.0030199745669960976,
0.012290004640817642,
-0.009198357351124287,
-0.02741147391498089,
0.02480018138885498,
-0.009603179059922695,
-0.00507314270362258,
0.022599071264266968,
-0.0023573616053909063,
-0.006465333513915539,
0.011461667716503143,
-0.0026932628825306892,
-0.03669894114136696,
-0.015290544368326664,
-0.0192577987909317,
-0.015201977454125881,
-0.0017304257489740849,
0.03919500857591629,
-0.026393350213766098,
-0.007434362545609474,
0.015140448696911335,
-0.0813659131526947,
0.003987305331975222,
-0.005959504283964634,
-0.021501261740922928,
0.0004181484691798687,
-0.010172506794333458,
0.006459355354309082,
0.0026656859554350376,
0.01773574762046337,
-0.012820378877222538,
0.028782078996300697,
-0.019574573263525963,
0.01893487758934498,
-0.010381018742918968,
0.007711697835475206,
-0.00540568633005023,
0.020071405917406082,
0.03478299081325531,
-0.013296697288751602,
-0.011250466108322144,
0.013523665256798267,
0.033245719969272614,
-0.00571083091199398,
0.0031227003782987595,
-0.008736864663660526,
0.0042173489928245544,
-0.04979560524225235,
0.01368204690515995,
-0.012778002768754959,
0.004100017249584198,
0.011018196120858192,
0.05038481578230858,
-0.015274139121174812,
-0.040493451058864594,
-0.01754113659262657,
-0.016659069806337357,
0.024568436667323112,
-0.0166381374001503,
0.01665976271033287,
-0.010537810623645782,
-0.0056081428192555904,
0.0021934444084763527,
-0.01166605670005083,
-0.002913927659392357,
-0.026148363947868347,
0.006017403677105904,
0.009444057941436768,
-0.002132103778421879,
0.009093508124351501,
0.00789979100227356,
0.01626768708229065,
-0.005745206493884325,
0.0058739567175507545,
-0.014043189585208893,
0.008352644741535187,
0.004971842747181654,
-0.007457226514816284,
0.01996377855539322,
0.014139292761683464,
-0.0005635938141494989,
-0.01797926425933838,
-0.002056905534118414,
-0.011962292715907097,
0.07240660488605499,
-0.015359092503786087,
0.01297965832054615,
-0.0051994603127241135,
0.03237329423427582,
0.0016008138190954924,
-0.010127944871783257,
-0.019016491249203682,
0.009979331865906715,
0.00009275018237531185,
-0.010873147286474705,
-0.011808529496192932,
0.028000300750136375,
0.013907422311604023,
-0.010788149200379848,
-0.010593830607831478,
-0.042960457503795624,
0.0005891285836696625,
-0.021900491788983345,
-0.005432017147541046,
0.0023522048722952604,
0.021666767075657845,
-0.015213359147310257,
0.008777855895459652,
0.008700577542185783,
0.015357088297605515,
0.008072823286056519,
-0.009159263223409653,
-0.021368753165006638,
0.0012177638709545135,
-0.0040908632799983025,
0.005936874076724052,
0.010833019390702248,
0.03599068522453308,
-0.004289013333618641,
-0.004245271440595388,
0.025188228115439415,
-0.00130606594029814,
0.0070407576858997345,
-0.05568818747997284,
-0.006766701117157936,
0.0012499531731009483,
0.015677694231271744,
0.005024563055485487,
0.03728720545768738,
0.028741713613271713,
0.015300242230296135,
-0.0014220909215509892,
0.009781653992831707,
0.014588240534067154,
0.014752764254808426,
0.0024437815882265568,
0.015089573338627815,
-0.0133349085226655,
0.022155990824103355,
0.012101622298359871,
-0.018033355474472046,
0.011126995086669922,
-0.011874502524733543,
-0.025531915947794914,
0.006234310567378998,
-0.00036726403050124645,
0.02155078575015068,
0.002753758803009987,
0.002403468359261751,
0.022013649344444275,
0.015312109142541885,
-0.01171933300793171,
-0.005247029010206461,
0.015068656764924526,
-0.022771641612052917,
0.005067632999271154,
0.006651764735579491,
-0.014215638861060143,
-0.0047544450499117374,
0.007648146711289883,
-0.00610168045386672,
-0.018177300691604614,
0.006589759141206741,
-0.001308088656514883,
-0.012843847274780273,
0.00022444501519203186,
0.017516925930976868,
0.01956305280327797,
-0.013896974734961987,
-0.001808258704841137,
0.01283251866698265,
0.0020466905552893877,
-0.012800068594515324,
0.006022983696311712,
0.0039061028510332108,
0.007032172754406929,
0.002411674242466688,
0.005138486623764038,
0.005304244346916676,
0.03348881006240845,
-0.012674912810325623,
0.005487182643264532,
-0.022224072366952896,
-0.013479565270245075,
0.03483704477548599,
0.024483416229486465,
0.01709752157330513,
0.005194239318370819,
0.011060181073844433,
-0.0017700099851936102,
0.013814784586429596,
-0.00018914975225925446,
0.0019390019588172436,
-0.0006498671136796474,
0.00465423846617341,
0.02032008394598961,
0.016057655215263367,
0.022450828924775124,
-0.0010990927694365382,
0.021275155246257782,
-0.014157978817820549,
-0.00998586043715477,
-0.0016704495064914227,
-0.011939368210732937,
-0.016750585287809372,
-0.015162709169089794,
-0.018495872616767883,
-0.017599139362573624,
-0.006139957346022129,
-0.0008461510296911001,
-0.0012744306586682796,
-0.007176665589213371,
0.018595293164253235,
-0.008403354324400425,
0.01319874543696642,
0.009128933772444725,
-0.02595505118370056,
-0.007642331533133984,
0.0001023770309984684,
-0.018288597464561462,
0.0007248581969179213,
0.04091540724039078,
0.0016399675514549017,
0.014407595619559288,
0.009015655145049095,
0.008573120459914207,
0.012819111347198486,
-0.0025684938300400972,
0.006592901423573494,
-0.010264935903251171,
0.005838016048073769,
0.027199015021324158,
0.014384412206709385,
0.0011973935179412365,
0.004700718447566032,
0.00044288462959229946,
-0.011371980421245098,
-0.004075724631547928,
-0.01514233648777008,
0.022896800190210342,
-0.0004144357517361641,
0.026224562898278236,
-0.016564317047595978,
-0.020098308101296425,
-0.0253897737711668,
-0.01618913747370243,
0.013584507629275322,
-0.001656580832786858,
0.004501668736338615,
0.024483369663357735,
0.024224119260907173,
0.0017233062535524368,
-0.02011074684560299,
0.025477122515439987,
0.020131126046180725,
-0.005792873911559582,
-0.00154144037514925,
-0.0002979703713208437,
-0.017945725470781326,
-0.018453776836395264,
-0.015295863151550293,
0.00345887104049325,
0.0010733595117926598,
0.003849244676530361,
0.01814153976738453,
-0.0056409090757369995,
0.011757200583815575,
-0.015290848910808563,
-0.0012841791613027453,
0.0035242238081991673,
-0.009054852649569511,
-0.003658861853182316,
0.018350183963775635,
-0.005355272442102432,
-0.011304883286356926,
-0.004708744585514069,
-0.015080152079463005,
0.0037833410315215588,
0.01087145321071148,
0.02708168886601925,
-0.014017101377248764,
0.02325650304555893,
-0.0035375049337744713,
-0.024488605558872223,
-0.014211485162377357,
-0.01928693801164627
] | [
0.6020914912223816,
0.1683308333158493,
0.2308393269777298,
0.009274662472307682,
-0.23449194431304932,
0.21039804816246033,
0.7468563318252563,
-0.69764244556427,
0.11085569858551025,
-0.1597474068403244,
-0.189239040017128,
0.5741905570030212,
-0.24357372522354126,
-0.2397049069404602,
-0.33198070526123047,
0.30288559198379517,
0.9231433868408203,
-0.15252681076526642,
-0.5361995100975037,
-0.5058448314666748,
-0.5094672441482544,
0.008459577336907387,
0.2379404455423355,
0.00942700169980526,
0.0863165408372879,
0.26002588868141174,
0.4758813977241516,
0.07359332591295242,
0.07256428897380829,
-0.40916964411735535,
0.2443872094154358,
0.1889694333076477,
-0.006293796468526125,
-0.8371748924255371,
0.5205784440040588,
0.1420275866985321,
0.5455132126808167,
-0.07935025542974472,
0.06984029710292816,
-0.95079505443573,
-0.11423949152231216,
0.29536309838294983,
0.09807164967060089,
0.4759784936904907,
0.04752204194664955,
-0.1745115965604782,
-1.1734946966171265,
0.551357090473175,
-0.32220348715782166,
0.42820727825164795,
-0.10611540079116821,
0.4547978341579437,
0.7152965068817139,
0.1695401668548584,
0.1641388088464737,
0.1679186224937439,
-0.871670663356781,
-0.35784637928009033,
-0.25660714507102966,
-0.11119794100522995,
0.09103447943925858,
0.36354464292526245,
-0.19492194056510925,
0.39851149916648865,
-0.3012009263038635,
0.3909335434436798,
0.1451210379600525,
0.1451890468597412,
0.0799877792596817,
-0.3194941282272339,
0.11468728631734848,
-0.6010388731956482,
-0.4328475594520569,
-0.1860647350549698,
-0.23033419251441956,
-0.27541980147361755,
-0.3524630069732666,
-0.29953205585479736,
0.6472150683403015,
-0.436252236366272,
0.05228935182094574,
0.2800544500350952,
0.19486959278583527,
-0.39234021306037903,
0.7167099118232727,
-0.0024834906216710806,
-0.20783181488513947,
0.24185551702976227,
-0.2619069814682007,
0.050317514687776566,
-0.37553292512893677,
-0.5768314003944397,
0.6380823850631714,
0.2414582222700119,
0.5572730302810669,
0.18595848977565765,
0.05959676206111908,
-0.06953950226306915,
0.41872164607048035,
0.06031973287463188,
0.3069673776626587,
0.19151434302330017,
-0.46801164746284485,
-0.1234511062502861,
-0.23431268334388733,
0.2632133364677429,
-0.30672645568847656,
-1.1016043424606323,
-0.27646440267562866,
0.31927236914634705,
-0.8192581534385681,
-0.044424138963222504,
-0.18614153563976288,
-0.6703774333000183,
-0.18694891035556793,
-0.22169624269008636,
0.23182398080825806,
-0.0021241111680865288,
-0.4059489965438843,
0.46868327260017395,
-0.08261203020811081,
0.8363162279129028,
-0.06438484787940979,
0.18585573136806488,
0.08257097005844116,
-0.006729290820658207,
0.20720700919628143,
0.5950357913970947,
-0.4421725571155548,
0.11549068987369537,
0.09183764457702637,
0.24940311908721924,
0.04935202747583389,
-0.1934068351984024,
0.07793621718883514,
-0.5695138573646545,
0.1472669094800949,
0.07933443784713745,
0.49789974093437195,
0.6094017028808594,
-0.05917833745479584,
-0.3374950587749481,
-0.3811752498149872,
-0.14054426550865173,
0.19887419044971466,
-0.060057807713747025,
0.21198655664920807,
-0.4621565043926239,
0.12750661373138428,
0.014209048822522163,
0.04919103533029556,
0.09217891097068787,
-0.24014022946357727,
-0.316426545381546,
-0.12496553361415863,
0.5416626334190369,
0.335649311542511,
-0.2328924536705017,
-0.18536309897899628,
-0.22038386762142181,
0.593976616859436,
-0.06544670462608337,
-0.2709804177284241,
0.19701437652111053,
0.4586939513683319,
0.16037632524967194,
-0.6938713788986206,
0.20518065989017487,
0.4854798913002014,
0.30120834708213806,
-0.7111539244651794,
0.3529623746871948,
-0.10683702677488327,
-0.39683258533477783,
-0.10065308213233948,
0.5369360446929932,
0.36536905169487,
0.21857686340808868,
0.1896304041147232,
0.06738387793302536,
-0.4712691605091095,
-0.20796242356300354,
-0.022277483716607094,
-0.8194783329963684,
0.5364452004432678,
-0.7166076302528381,
0.19043521583080292,
-0.09654545783996582,
0.30075570940971375,
0.8042020201683044,
0.024433227255940437,
0.2412116974592209,
0.7171591520309448,
-0.45804333686828613,
1.4967331886291504,
-0.5009282827377319,
-0.5078137516975403,
1.1287901401519775,
0.45266714692115784,
-0.05413796752691269,
0.09445712715387344,
0.2717823088169098,
0.2176051288843155,
-0.350364625453949,
-0.7044055461883545,
-0.22497503459453583,
-0.028333041816949844,
-0.1612987369298935,
-0.26994553208351135,
-0.03770177438855171,
-0.053829748183488846,
-0.42521870136260986,
-0.11110611259937286,
-0.10191784054040909,
0.27649033069610596,
-0.04951447248458862,
-0.06578268855810165,
0.3159535229206085,
-0.22656145691871643,
-0.1320270597934723,
0.6376357078552246,
-0.6704146265983582,
0.032947275787591934,
0.7657509446144104,
-0.5200998187065125,
0.6882361173629761,
0.25123080611228943,
0.1527480185031891,
1.0150768756866455,
-0.5442888736724854,
0.354809433221817,
-0.022430114448070526,
0.2980271279811859,
-0.27358606457710266,
0.019389573484659195,
0.4515841007232666,
-0.0837814137339592,
-0.89406418800354,
0.29422539472579956,
-0.24518446624279022,
0.0440957136452198,
-0.04169122502207756,
-0.30340272188186646,
0.40288951992988586,
0.21767595410346985,
0.4145538806915283,
-0.3981817960739136,
0.6709160208702087,
-0.7982391715049744,
0.6475942134857178,
0.26913028955459595,
-0.34170499444007874,
0.030460299924016,
-0.6280957460403442,
-0.3077676296234131,
-0.12076438218355179,
0.04146279767155647,
-0.6026259064674377,
-0.20751897990703583,
-0.17406170070171356,
-0.5809253454208374,
-0.2381465584039688,
-0.01649472676217556,
0.5833706259727478,
-0.012862696312367916,
-0.7245277166366577,
-0.14897270500659943,
-0.725399911403656,
0.7880116105079651,
0.2025730013847351,
0.2564344108104706,
0.20106709003448486,
-0.7753040790557861,
0.4270966053009033,
-0.20127226412296295,
-0.2008780539035797,
-0.061548445373773575,
0.47958216071128845,
-0.020435700193047523,
-0.11189877986907959,
-0.3123989701271057,
0.35844194889068604,
0.9328759908676147,
-0.20788748562335968,
0.013999915681779385,
0.12277626246213913,
0.09137683361768723,
-0.5630926489830017,
-0.6434887051582336,
-0.11393260955810547,
0.14110897481441498,
0.5395054817199707,
-0.1111818477511406,
-0.249301478266716,
0.3232634961605072,
0.05754813179373741,
-0.5359369516372681,
0.47515997290611267,
0.12207155674695969,
0.1479315459728241,
0.4780273139476776,
-0.06328042596578598,
-0.0874999463558197,
0.27915677428245544,
0.17403490841388702,
-0.2969124913215637,
-0.2840324342250824,
-0.011427960358560085,
-5.760956287384033,
0.5361360311508179,
-0.4767548441886902,
0.04191625490784645,
-0.18768925964832306,
0.30319854617118835,
1.0449748039245605,
-0.3850099444389343,
-0.22678501904010773,
-0.17045661807060242,
-0.4608244299888611,
0.5119794011116028,
0.5400179624557495,
0.8620620369911194,
0.2287793606519699,
0.5953087210655212,
-0.09271395206451416,
-0.5543228983879089,
0.12099259346723557,
0.2706867754459381,
0.31892234086990356,
-0.09969773143529892,
0.275296688079834,
0.7406436800956726,
-0.0006035700789652765,
-0.1954873502254486,
-0.8957804441452026,
0.19753769040107727,
0.29189160466194153,
-0.2424771934747696,
0.13666093349456787,
-0.3020394742488861,
-0.15623512864112854,
-0.23071645200252533,
0.456434428691864,
0.40308424830436707,
0.5070883631706238,
-0.10838813334703445,
-0.6137965321540833,
-0.8294609785079956,
0.11509735882282257,
-0.013010150752961636,
0.055944956839084625,
0.05627259612083435,
0.23034162819385529,
0.10365767031908035,
-0.06327912211418152,
0.10230989754199982,
-0.5908837914466858,
0.6698252558708191,
0.31394457817077637,
0.07579708099365234,
0.5272325277328491,
0.41508838534355164,
0.11088323593139648,
-0.31639328598976135,
-0.3073658347129822,
0.2965095043182373,
0.12813298404216766,
0.1978602111339569,
-0.3291090428829193,
-0.08466701954603195,
-0.25164929032325745,
-0.5129517316818237,
-0.04005929455161095,
0.24313431978225708,
-0.7998818755149841,
-0.26261037588119507,
0.44351863861083984,
0.4021454453468323,
-0.7123634219169617,
0.013670379295945168,
-0.5450543165206909,
-0.6700552105903625,
0.8807079792022705,
-0.16477864980697632,
0.6789429783821106,
-0.010912727564573288,
0.2629898488521576,
0.019061388447880745,
0.185983806848526,
0.09821852296590805,
0.2109537571668625,
-0.21547262370586395,
0.039737895131111145,
-0.16292579472064972,
0.6084690690040588,
0.3872162401676178,
-0.614133894443512,
0.17978137731552124,
0.31312692165374756,
0.16937166452407837,
-0.16361021995544434,
0.36846062541007996,
0.33754661679267883,
0.07752519845962524,
0.38642579317092896,
-0.3841593563556671,
0.6389748454093933,
-0.17959590256214142,
0.7419432401657104,
0.2129697948694229,
-0.07405001670122147,
-0.7406769394874573,
-0.6336780190467834,
-0.19551962614059448,
-0.5192539095878601,
0.18862317502498627,
0.88028883934021,
-0.18297059834003448,
-0.39572641253471375,
-0.031562987715005875,
-0.33395400643348694,
-0.1562211811542511,
0.6063447594642639,
-0.2586451470851898,
-0.22029675543308258,
-0.33066245913505554,
0.02595306560397148,
0.11379454284906387,
-0.04883185029029846,
0.10505063086748123,
0.18681086599826813,
0.0846593901515007,
-0.1763305813074112,
-0.15197600424289703,
0.24666500091552734,
-0.10792547464370728,
-0.5020643472671509,
0.23514479398727417,
0.2928280830383301,
0.2707294523715973,
-0.527916669845581,
-0.15874400734901428,
0.3436107635498047,
-0.14770318567752838,
-0.3055381178855896,
0.08155589550733566,
-0.023682361468672752,
0.0631457269191742,
0.32742589712142944,
-0.3083716332912445,
-0.15273533761501312,
0.5458304286003113,
-0.1176118329167366,
0.23752237856388092,
-0.28044000267982483,
0.2727302610874176,
-0.3333069980144501,
0.16996708512306213,
-0.011467101983726025,
0.28546133637428284,
-0.10485374182462692,
-0.22324511408805847,
0.09613238275051117,
0.23796501755714417,
-0.12929943203926086,
-0.16959266364574432,
0.44691717624664307,
-0.46073436737060547,
0.09997795522212982,
0.1508282572031021,
-1.397373080253601,
-0.2559663653373718,
0.16494220495224,
-0.3309166729450226,
-0.612057089805603,
-0.5584178566932678,
-0.3328530788421631,
0.019132651388645172,
-0.39154252409935,
-0.015885505825281143,
0.12170163542032242,
-0.4511597752571106,
0.19308353960514069,
-0.0822129026055336,
-0.25840914249420166,
0.11279811710119247,
-0.030576199293136597,
-0.08762442320585251,
0.4652688205242157,
-0.8445331454277039,
-0.18161541223526,
-0.07499339431524277,
0.6909475326538086,
-0.20883846282958984,
-0.08441656082868576,
-0.20747902989387512,
-0.16904784739017487,
-0.28586912155151367,
0.49017247557640076,
0.3156367242336273,
-0.022398730739951134,
0.20867832005023956,
0.09824332594871521,
-0.7156811356544495,
0.1502925157546997,
0.9349524974822998,
-0.11869025975465775,
-0.12310483306646347,
0.38164302706718445,
0.19922718405723572,
-1.0180085897445679,
0.5908083915710449,
0.25966912508010864,
-0.12050579488277435,
0.13833871483802795,
-0.16558264195919037,
0.35819122195243835,
0.06691106408834457,
-0.2535429298877716,
-0.48349785804748535,
-0.35925596952438354,
0.5345257520675659,
-0.6028436422348022,
0.3891734480857849,
-0.6917963624000549,
-0.5020262598991394,
-0.2520751357078552,
0.26238739490509033,
0.002998890122398734,
-0.2628720700740814,
-0.32320839166641235,
0.022206749767065048,
-0.2460245043039322,
-0.017975253984332085,
0.5586181879043579,
-0.9377737045288086,
-0.9134698510169983,
0.34379422664642334,
0.38025611639022827,
0.12604394555091858,
-0.38424164056777954,
-0.274478554725647,
-0.6358741521835327,
-0.4612024426460266,
-0.7822900414466858,
0.21313297748565674,
0.16665668785572052,
0.013861608691513538,
-0.7723500728607178,
0.4874648451805115,
-0.1942892223596573,
-0.39677566289901733,
-0.37420618534088135,
0.40356728434562683,
-0.0655616894364357,
-0.6345904469490051,
-0.44068145751953125,
0.2934150695800781,
0.587139904499054,
-0.10246255993843079,
0.28826355934143066,
-0.5444247126579285,
0.280396968126297,
0.08579456806182861,
-0.2616596519947052,
-0.1578168421983719,
0.0571596585214138,
0.5327066779136658,
-0.02576671727001667,
-0.5164179801940918,
-0.48864617943763733,
-0.28237369656562805,
-0.024952393025159836,
0.13671515882015228,
0.4266801178455353,
-1.208520770072937,
-0.1711793839931488,
-0.9417923092842102,
0.08783194422721863,
-0.13839145004749298,
0.6152113080024719,
0.22920380532741547,
0.2462695688009262,
-0.44777804613113403,
-0.08726886659860611,
-0.5382641553878784,
-0.4042746424674988,
0.3631337881088257,
0.15363238751888275,
0.05908503383398056,
-0.12009739130735397,
0.22520744800567627,
0.28158432245254517,
-1.042836308479309,
0.20201747119426727,
0.2217128872871399,
-0.45262446999549866,
-0.08260271698236465,
0.06441935896873474,
-0.22934721410274506,
-0.20451083779335022,
0.3636719286441803,
-0.06089482456445694,
0.39658594131469727,
0.5072359442710876,
0.0072390129789710045,
0.2238604873418808,
-0.0033303163945674896,
-0.34241360425949097,
0.8163038492202759,
1.1192618608474731,
-0.2502579987049103,
-0.34241145849227905,
0.11936164647340775,
0.042516935616731644,
-0.41199806332588196,
-0.38970762491226196,
0.8157579302787781,
0.15678855776786804,
-0.47170472145080566,
0.47223785519599915,
0.5159657001495361,
-0.5446580648422241,
-0.1283981055021286,
-0.3946671783924103,
-0.21573269367218018,
0.6569402813911438,
0.06380392611026764,
0.08862949907779694,
0.7379897832870483,
0.5840080380439758,
0.2327817976474762,
-0.08437185734510422,
0.40273115038871765,
-0.2788415849208832,
0.37707221508026123,
-0.13967794179916382,
0.06711757928133011,
0.8476231098175049,
0.6311898827552795,
0.12184380739927292,
0.25892212986946106,
0.12889936566352844,
-0.07849135249853134,
0.21475791931152344,
0.05708567798137665,
-0.3085590898990631,
-0.13609372079372406,
0.25894683599472046,
0.11049360036849976,
-0.2966168522834778,
0.2506583333015442,
0.3312905728816986,
0.05462237074971199,
0.28420883417129517,
-0.0802883431315422,
-0.4991483986377716,
0.7015745639801025,
0.6929491758346558,
-0.08808239549398422,
0.03697679564356804,
0.22085554897785187,
-0.32509350776672363,
0.18682025372982025,
0.44771555066108704,
-0.028432054445147514,
-0.0656641498208046,
0.2810650169849396,
0.21242961287498474,
0.28481152653694153,
-0.599812388420105,
0.19802838563919067,
-0.7039279937744141,
-0.044658541679382324,
0.5645142197608948,
-0.3399946987628937,
0.23156118392944336,
0.2444273829460144,
-0.19133581221103668,
0.30233561992645264,
-0.34448617696762085,
0.35097289085388184,
-0.10019318014383316,
-1.0651124715805054,
0.5294156670570374,
-0.09775973111391068,
0.0661383792757988,
0.8883843421936035,
-0.22177131474018097,
0.06763084977865219,
-0.27863356471061707,
-0.6296730637550354,
0.08361928164958954,
-0.24926654994487762,
0.10308428108692169,
0.26836615800857544,
0.015974394977092743,
-0.21482841670513153,
-0.1500329077243805,
0.12639233469963074,
-0.08051778376102448,
0.31953170895576477,
0.08768635243177414,
0.29137399792671204,
-0.06536030024290085,
0.5914843678474426,
0.20134907960891724,
0.5281277298927307,
-0.5983372926712036,
0.4143699109554291,
0.056770287454128265,
0.10449033230543137,
0.18194328248500824,
0.006495386362075806,
-0.3123939633369446,
-0.6479465961456299,
-0.7965126037597656,
0.22053486108779907,
0.8272574543952942,
0.4586373567581177,
-0.1011166125535965,
0.3441961407661438,
0.4632027745246887,
0.6404450535774231,
0.3359432518482208,
-0.44674092531204224,
-0.26555711030960083,
-0.057868264615535736,
0.04779452830553055,
-0.3540987968444824,
0.5696514844894409,
0.3400116562843323,
-0.2188737988471985,
-0.3183715045452118,
0.4971523880958557,
-0.3297978639602661,
0.046634431928396225,
0.22085687518119812,
-0.21394163370132446,
-0.4740114212036133,
-0.6059014201164246,
0.6904203295707703,
-0.8938345313072205,
-0.29837942123413086,
-0.3235972225666046,
0.3779888451099396,
0.36710405349731445,
-0.0669761523604393,
0.10941755026578903,
-0.47349655628204346,
-0.20249851047992706,
0.16275708377361298,
0.23832710087299347,
0.4471512734889984,
-0.34951871633529663,
-0.09607305377721786,
-0.7445921301841736,
-0.11088637262582779,
-0.1116652563214302,
-0.9916340112686157,
0.024785758927464485,
-0.4949018955230713,
-0.4852890372276306,
0.05655970424413681,
-0.2182389497756958,
-0.6066177487373352,
-0.15074928104877472,
-0.007312899921089411
] |
Defective brain hormonal signaling has been associated with Alzheimer's disease (AD), a disorder characterized by synapse and memory failure. Irisin is an exercise-induced myokine released on cleavage of the membrane-bound precursor protein fibronectin type III domain-containing protein 5 (FNDC5), also expressed in the hippocampus. Here we show that FNDC5/irisin levels are reduced in AD hippocampi and cerebrospinal fluid, and in experimental AD models. Knockdown of brain FNDC5/irisin impairs long-term potentiation and novel object recognition memory in mice. Conversely, boosting brain levels of FNDC5/irisin rescues synaptic plasticity and memory in AD mouse models. Peripheral overexpression of FNDC5/irisin rescues memory impairment, whereas blockade of either peripheral or brain FNDC5/irisin attenuates the neuroprotective actions of physical exercise on synaptic plasticity and memory in AD mice. By showing that FNDC5/irisin is an important mediator of the beneficial effects of exercise in AD models, our findings place FNDC5/irisin as a novel agent capable of opposing synapse failure and memory impairment in AD. | [
-0.007585577666759491,
-0.005456722341477871,
-0.018223010003566742,
0.006306048482656479,
0.017298320308327675,
-0.0008819359354674816,
0.010259244590997696,
0.025653168559074402,
-0.011904887855052948,
0.040420979261398315,
-0.013544540852308273,
0.0018721489468589425,
-0.016829151660203934,
0.004745488986372948,
0.0021474179811775684,
-0.003404067363590002,
-0.0005533815128728747,
0.013766704127192497,
0.01397615298628807,
0.018080372363328934,
0.011699581518769264,
-0.01474239956587553,
0.011015623807907104,
0.02382703870534897,
0.02283383160829544,
0.004210012033581734,
0.017936229705810547,
-0.019327325746417046,
-0.03580021113157272,
-0.0015531964600086212,
0.01036999560892582,
-0.004125577863305807,
0.0011484669521450996,
0.05131963640451431,
0.0006077049765735865,
-0.007304954342544079,
-0.013799602165818214,
0.02824234776198864,
-0.006486448459327221,
-0.00619213841855526,
0.00357972108758986,
-0.010881572030484676,
0.008423933759331703,
0.017988048493862152,
-0.010113188996911049,
-0.016217578202486038,
-0.0006048822542652488,
-0.006221975665539503,
0.015494998544454575,
0.006366598419845104,
-0.010284144431352615,
-0.03591637685894966,
-0.012958873063325882,
0.010534398257732391,
-0.006611324846744537,
0.009459135122597218,
0.01860765367746353,
-0.007692005950957537,
-0.026337604969739914,
0.021143395453691483,
0.011445049196481705,
-0.010996738448739052,
0.012213731184601784,
-0.018930763006210327,
-0.0037768129259347916,
-0.06623374670743942,
-0.004240790847688913,
0.0032400800846517086,
0.01278623566031456,
-0.034637659788131714,
-0.019509276375174522,
0.0072534652426838875,
-0.014617408625781536,
0.007446350529789925,
-0.03990479186177254,
-0.007273413240909576,
0.01167469471693039,
-0.004364257678389549,
0.022266216576099396,
-0.006707142107188702,
-0.011691467836499214,
-0.004846267867833376,
0.024578841403126717,
0.0015250067226588726,
0.017841821536421776,
-0.004856590647250414,
-0.036065198481082916,
-0.019763566553592682,
-0.018131449818611145,
0.004298323765397072,
-0.022594790905714035,
0.017367852851748466,
-0.00442040991038084,
-0.00434704776853323,
-0.021407824009656906,
-0.022005677223205566,
0.009157851338386536,
0.001732607837766409,
0.014365792274475098,
-0.0176783949136734,
-0.032303690910339355,
-0.010752446949481964,
0.01595114916563034,
0.015914862975478172,
-0.007190094329416752,
0.0058565386570990086,
0.011537788435816765,
0.01696060225367546,
0.001365309813991189,
0.012279094196856022,
-0.03732746094465256,
-0.01842501387000084,
-0.0018901992589235306,
0.04067649692296982,
0.000493811909109354,
0.021689532324671745,
-0.018182944506406784,
0.01176888681948185,
0.009265381842851639,
-0.013695661909878254,
0.019991852343082428,
0.024779707193374634,
0.015892155468463898,
-0.012868646532297134,
0.0007406304939649999,
-0.017293095588684082,
0.00019900966435670853,
0.010608112439513206,
-0.01865699328482151,
-0.008016804233193398,
-0.007263740990310907,
0.0068358322605490685,
-0.037917569279670715,
-0.007955518551170826,
-0.0219917930662632,
-0.011278977617621422,
0.01778232492506504,
0.006617755629122257,
0.00318863894790411,
-0.02400190941989422,
0.010580109432339668,
0.01087883673608303,
0.0035828612744808197,
0.018010221421718597,
0.038781896233558655,
0.004038095008581877,
0.011743945069611073,
0.004645665641874075,
0.015084316954016685,
-0.0020998073741793633,
0.003758905455470085,
0.006742000114172697,
-0.029844123870134354,
-0.008082540705800056,
0.0073456475511193275,
0.018335307016968727,
-0.019561730325222015,
-0.017295587807893753,
0.005061907693743706,
-0.0033212858252227306,
-0.021584974601864815,
0.007200282998383045,
-0.00659681623801589,
0.010218104347586632,
0.01220499537885189,
-0.01229773834347725,
0.008229943923652172,
-0.015573421493172646,
0.016057055443525314,
0.009469818323850632,
-0.005411779507994652,
0.014749554917216301,
-0.006314482539892197,
0.010221198201179504,
-0.02159736305475235,
-0.027376506477594376,
-0.01230053510516882,
0.006365315988659859,
0.006781932897865772,
0.06548373401165009,
-0.010806445963680744,
-0.0022514155134558678,
0.008970688097178936,
0.007187711074948311,
-0.02070527710020542,
-0.023867130279541016,
0.018661443144083023,
-0.007255648262798786,
0.0031291842460632324,
-0.016988340765237808,
-0.005671977531164885,
-0.042442746460437775,
-0.002251706086099148,
-0.007546569220721722,
-0.012841295450925827,
0.0022122093942016363,
0.02685396932065487,
0.02211446687579155,
-0.0026146043092012405,
0.003355576889589429,
0.008569847792387009,
-0.009388554841279984,
0.022200195118784904,
-0.022904524579644203,
0.03346936032176018,
-0.005906896665692329,
0.01118609681725502,
-0.0264621339738369,
-0.03554914519190788,
-0.04223663732409477,
0.02314572036266327,
-0.0388166569173336,
0.01238416600972414,
-0.0232503991574049,
-0.004411266651004553,
-0.0016098732594400644,
0.008814480155706406,
-0.0028895928990095854,
-0.009763108566403389,
-0.008020872250199318,
0.0014152535004541278,
0.0002768426202237606,
0.002216939814388752,
-0.013334489427506924,
-0.002161493059247732,
-0.005332895554602146,
0.006835279054939747,
0.015891902148723602,
-0.0034811515361070633,
-0.001102569978684187,
-0.03412199392914772,
-0.045674555003643036,
-0.01478575263172388,
-0.0014669615775346756,
0.017812851816415787,
-0.002003224566578865,
0.016509881243109703,
0.015151810832321644,
0.00316756428219378,
-0.009394275955855846,
0.005562701262533665,
-0.0196255911141634,
0.012530870735645294,
-0.014615820720791817,
0.009670384228229523,
0.009535882622003555,
-0.032839853316545486,
0.004023912362754345,
-0.009444990195333958,
-0.01674865558743477,
0.007698202971369028,
-0.022671937942504883,
-0.028139356523752213,
-0.005950851831585169,
-0.018256310373544693,
-0.013883226551115513,
0.0027869082987308502,
-0.02100740745663643,
0.027155082672834396,
-0.0033914828673005104,
0.005717470310628414,
0.0044819870963692665,
-0.02054792270064354,
0.03400082141160965,
-0.02829359471797943,
0.01798315718770027,
0.019548606127500534,
-0.0019610398449003696,
0.008926399983465672,
0.01652112603187561,
0.008036342449486256,
-0.010478893294930458,
-0.0050026606768369675,
-0.08119189739227295,
-0.006806132383644581,
0.022388186305761337,
0.007346269674599171,
0.0059372130781412125,
-0.0042446814477443695,
-0.0030186669901013374,
-0.0027339723892509937,
-0.0033745449036359787,
-0.007512514945119619,
0.00996117852628231,
0.02794317714869976,
-0.0025443071499466896,
0.020915145054459572,
-0.027257762849330902,
0.004309211857616901,
0.013019369915127754,
-0.007611023262143135,
-0.012039488181471825,
-0.041479822248220444,
-0.0004853375721722841,
-0.01059817522764206,
-0.03641333803534508,
0.008493556641042233,
-0.028774674981832504,
-0.003950696438550949,
-0.014632013626396656,
-0.021517779678106308,
-0.027643030509352684,
-0.00012157164746895432,
-0.024614568799734116,
-0.010974266566336155,
-0.006017337553203106,
0.012032559141516685,
-0.013660091906785965,
0.026804164052009583,
-0.0038565672002732754,
-0.028361186385154724,
-0.007440948858857155,
-0.006827682256698608,
-0.019488878548145294,
-0.0007056191097944975,
0.04835924878716469,
-0.004260101355612278,
0.014131455682218075,
0.006178475450724363,
-0.008233246393501759,
0.028040099889039993,
0.021814147010445595,
-0.025588439777493477,
0.0035790810361504555,
-0.005878387950360775,
-0.016488773748278618,
0.024854369461536407,
-0.0014593785163015127,
0.002527403412386775,
0.0009068315848708153,
0.004787996411323547,
-0.0066946325823664665,
-0.011527994647622108,
-0.0077353306114673615,
0.000944117084145546,
0.036577314138412476,
-0.011578483507037163,
0.004851894918829203,
-0.00550415925681591,
0.005232019349932671,
-0.018040679395198822,
-0.004898103419691324,
0.016303671523928642,
-0.016337580978870392,
-0.029156364500522614,
-0.02357620745897293,
-0.011430758982896805,
0.005708564072847366,
-0.007029883097857237,
-0.0140247642993927,
-0.0090100122615695,
0.012271566316485405,
-0.007071996573358774,
0.012661512941122055,
0.009637177921831608,
-0.03041785955429077,
-0.01619046926498413,
-0.03580828011035919,
-0.014256344176828861,
0.005322106182575226,
0.010358091443777084,
0.010566373355686665,
-0.01298120990395546,
0.04467657580971718,
0.03768870234489441,
-0.014419770799577236,
0.01820734143257141,
0.006266451440751553,
0.011340387165546417,
0.0018983031623065472,
0.005473524332046509,
-0.000619715778157115,
0.006717115640640259,
-0.03475896269083023,
0.013950743712484837,
-0.03677333891391754,
-0.006808460224419832,
-0.0001798388548195362,
0.014972160570323467,
-0.006639035418629646,
-0.021367397159337997,
0.025721043348312378,
0.003445534035563469,
0.006322194822132587,
-0.04115425795316696,
-0.0009019952267408371,
0.023153668269515038,
0.009037772193551064,
0.020493891090154648,
-0.011098896153271198,
-0.013609864749014378,
0.071843720972538,
0.01076325960457325,
-0.013467159122228622,
-0.011738362722098827,
0.032864078879356384,
-0.011034050956368446,
0.020852088928222656,
0.011556776240468025,
0.006499522365629673,
0.03540278226137161,
0.013896247372031212,
-0.05120951682329178,
0.008074477314949036,
0.0376751646399498,
-0.0030649928376078606,
-0.016917051747441292,
-0.023887433111667633,
-0.03612674027681351,
0.029539775103330612,
0.014300743117928505,
-0.006435010582208633,
-0.010945172980427742,
0.014895383268594742,
-0.0025550436694175005,
0.009341690689325333,
-0.029823647812008858,
-0.020389070734381676,
-0.012295488268136978,
0.0029916265048086643,
0.01307564415037632,
-0.03046489879488945,
0.006520943250507116,
-0.009309396147727966,
-0.011934924870729446,
0.01007772609591484,
0.005895465146750212,
0.0315018966794014,
-0.02606521174311638,
-0.00908513180911541,
-0.015356800518929958,
0.020973075181245804,
-0.017520520836114883,
0.006349718198180199,
0.0029605065938085318,
-0.0398092195391655,
0.0007537086494266987,
0.002992655150592327,
-0.01175636239349842,
0.012794086709618568,
-0.006807303987443447,
0.000815296545624733,
0.00005986541509628296,
0.011565427295863628,
-0.01683964766561985,
-0.014466410502791405,
-0.046270303428173065,
0.026434913277626038,
-0.008566596545279026,
-0.005795475095510483,
-0.028096064925193787,
-0.021514536812901497,
0.005690131802111864,
0.022391345351934433,
-0.001299866009503603,
0.010862639173865318,
-0.028808973729610443,
0.0026501573156565428,
0.005842466838657856,
-0.008367620408535004,
0.0077041685581207275,
0.01383771002292633,
0.01755555346608162,
-0.0003560246550478041,
-0.009847506880760193,
-0.02260296419262886,
-0.005644367076456547,
-0.0010826054494827986,
-0.006539946421980858,
0.046365462243556976,
0.006985322572290897,
-0.022307483479380608,
0.010691366158425808,
0.016891036182641983,
-0.018628714606165886,
0.011316918767988682,
-0.0013521299697458744,
-0.02264624461531639,
-0.07495147734880447,
-0.011601369827985764,
-0.0054826089181005955,
-0.006940317340195179,
0.00011175335384905338,
0.046513400971889496,
-0.027526384219527245,
0.0004576656501740217,
-0.01229960285127163,
-0.002199872862547636,
0.030241582542657852,
0.008225411176681519,
0.018616916611790657,
-0.0029352353885769844,
0.01029874011874199,
-0.014555294997990131,
-0.012352656573057175,
-0.000003969995304942131,
-0.00855326559394598,
-0.01739095337688923,
-0.021786920726299286,
0.0014245444908738136,
-0.025941189378499985,
-0.002142042387276888,
-0.017324917018413544,
-0.08061358332633972,
0.0025697974488139153,
0.015743883326649666,
-0.014269420877099037,
0.007752307690680027,
-0.003968830220401287,
0.007892349734902382,
-0.0003839589189738035,
-0.003435138612985611,
-0.019001152366399765,
0.013864285312592983,
-0.0030745938420295715,
-0.0355234295129776,
-0.016407111659646034,
0.0070629664696753025,
-0.010110265575349331,
0.012416930869221687,
0.012106853537261486,
0.0022382386960089207,
-0.0013151955790817738,
-0.013729180209338665,
-0.001632773783057928,
-0.008572847582399845,
-0.013849463313817978,
-0.006518859416246414,
-0.00856977328658104,
-0.019275277853012085,
0.016856107860803604,
0.006647190079092979,
-0.0024528149515390396,
-0.02506587654352188,
-0.0057023875415325165,
-0.019174816086888313,
0.01597512513399124,
0.01418411172926426,
-0.014787232503294945,
0.02800951711833477,
-0.01329510286450386,
0.02399234101176262,
-0.009499920532107353,
-0.001931081060320139,
0.011622780933976173,
0.007293551228940487,
0.010805288329720497,
-0.013439211063086987,
0.015490163117647171,
0.005954139865934849,
-0.008497139438986778,
0.008239557966589928,
-0.025849292054772377,
0.015569798648357391,
-0.017625395208597183,
0.0036927456967532635,
-0.0023767894599586725,
0.0390024334192276,
0.032703496515750885,
-0.00906689465045929,
0.0317496582865715,
-0.00932114664465189,
0.008286879397928715,
-0.01280905306339264,
0.0046036820858716965,
0.007354690693318844,
0.070978544652462,
-0.006045810412615538,
0.01477512251585722,
-0.0006435296963900328,
0.00829243939369917,
0.004399545025080442,
0.00039375200867652893,
-0.019997287541627884,
-0.007995030842721462,
-0.019691556692123413,
-0.02933652326464653,
-0.016271859407424927,
-0.014024525880813599,
0.0172724686563015,
-0.0048720864579081535,
-0.008347263559699059,
-0.000055254437029361725,
-0.00428488664329052,
-0.015399947762489319,
0.0358789898455143,
-0.008989136666059494,
0.02428445592522621,
-0.008379358798265457,
0.003943583928048611,
-0.004937537480145693,
-0.007758602034300566,
-0.005269468761980534,
0.015933837741613388,
0.002482691314071417,
0.005325864069163799,
0.01955774798989296,
-0.01749158278107643,
0.001025363802909851,
0.0033477144315838814,
0.0024294722825288773,
0.007002275437116623,
0.015008611604571342,
0.01914048008620739,
-0.01274828054010868,
-0.010406679473817348,
-0.006631513126194477,
-0.002835178282111883,
0.0015898412093520164,
0.005021438933908939,
0.020774373784661293,
0.000005602370947599411,
0.02597748301923275,
0.0028922241181135178,
-0.0003259330987930298,
0.01322848629206419,
-0.01318485289812088,
-0.006008683238178492,
0.01702229492366314,
-0.019376464188098907,
-0.01277925819158554,
0.0313897505402565,
-0.007130268029868603,
0.014504820108413696,
-0.02548281103372574,
0.022472195327281952,
0.0015731885796412826,
-0.019890043884515762,
-0.0002746116369962692,
-0.027689341455698013,
0.015359487384557724,
-0.006173867266625166,
0.0025565270334482193,
-0.008130769245326519,
-0.016588982194662094,
0.01535928063094616,
-0.017949342727661133,
0.020772796124219894,
0.011341109871864319,
0.04001094028353691,
0.030074670910835266,
0.006778833456337452,
0.04180969297885895,
0.009430957958102226,
0.02126467600464821,
0.008135540410876274,
-0.005427009426057339,
-0.002288497518748045,
-0.017445329576730728,
0.013083292171359062,
0.012944760732352734,
-0.011154331266880035,
-0.00002866378054022789,
-0.003823847509920597,
0.0071470486000180244,
0.007630393840372562,
-0.007701910566538572,
0.022429604083299637,
0.007162853144109249,
0.010931819677352905,
0.0075804078951478004,
0.03497034311294556,
0.042186036705970764,
-0.0016709193587303162,
-0.026598531752824783,
0.02085055597126484,
0.03422350436449051,
-0.0013818377628922462,
-0.0006205225363373756,
0.02133151888847351,
-0.003044066485017538,
-0.003964552655816078,
0.010549183934926987,
0.017336219549179077,
-0.0007444877410307527,
-0.014039754867553711,
0.0027923393063247204,
-0.00288894004188478,
0.03379373997449875,
0.035840995609760284,
0.0052849543280899525,
0.029911192134022713,
-0.010769659653306007,
0.0027346150018274784,
-0.025246068835258484,
-0.016506370157003403,
0.019986562430858612,
-0.0017109210602939129,
0.0014188853092491627,
-0.01265972200781107,
0.014565014280378819,
-0.028066769242286682,
-0.015775224193930626,
0.005647076293826103,
0.01426776498556137,
-0.016722528263926506,
0.02861464023590088,
0.03539666905999184,
-0.0191999189555645,
0.011362489312887192,
-0.013621971011161804,
0.0199723020195961,
-0.003239590208977461,
0.009897305630147457,
-0.0013765324838459492,
-0.005149647127836943,
-0.03312331438064575,
-0.004117980599403381,
-0.0018713411409407854,
-0.0250529982149601,
0.00930827483534813,
-0.017609916627407074,
0.004261772148311138,
0.030431929975748062,
0.012167993932962418,
-0.012871990911662579,
0.001290962565690279,
0.008732730522751808,
-0.010799833573400974,
-0.00739753432571888,
-0.0071241166442632675,
0.013508439064025879,
0.0018285304540768266,
-0.004459682386368513,
-0.009632552042603493,
0.008426791056990623,
0.009366631507873535,
-0.020831279456615448,
0.013022007420659065,
0.018650691956281662,
0.0027339141815900803,
-0.007084207609295845,
-0.020761098712682724,
-0.008185244165360928,
0.011344284750521183,
-0.0036689613480120897,
0.026951756328344345,
-0.005725718569010496,
-0.0007822266779839993,
0.02620808593928814,
-0.004650746937841177,
-0.00474619772285223,
0.004513219930231571,
-0.012105979025363922,
0.03998139128088951,
0.0029274786356836557,
0.025633960962295532,
-0.010674375109374523,
0.006143203005194664,
-0.015275441110134125,
-0.0006731523899361491,
-0.006747143343091011,
-0.007823925465345383,
-0.013770225457847118,
-0.00913613848388195,
-0.006603902671486139,
-0.008210595697164536,
0.006382649764418602,
-0.002242515329271555,
0.017156805843114853,
-0.0108141228556633,
-0.011016896925866604,
-0.024249527603387833,
-0.007450445089489222,
0.0043377042748034,
0.016223333775997162,
-0.009500086307525635,
0.000019662082195281982
] | [
-0.26428085565567017,
0.04835951328277588,
0.5430677533149719,
0.0045216572470963,
0.18531104922294617,
0.034480080008506775,
0.4529578983783722,
0.28606483340263367,
0.09632788598537445,
-0.47533127665519714,
-0.2750895023345947,
0.3904697299003601,
-0.5097953081130981,
-0.022100800648331642,
-0.04770009219646454,
0.412401407957077,
1.0020209550857544,
0.3109568953514099,
-0.6097872853279114,
-0.3549981713294983,
-0.16888897120952606,
-0.26539281010627747,
0.3611583411693573,
0.03516252711415291,
0.2150285542011261,
-0.346357524394989,
0.34115147590637207,
-0.11510231345891953,
0.20621274411678314,
-0.34995242953300476,
-0.0576632060110569,
0.47519469261169434,
0.22687967121601105,
-0.12090778350830078,
-0.3809186518192291,
0.29639124870300293,
-0.4296150803565979,
-0.6056540012359619,
0.12170670181512833,
0.3110383152961731,
-0.3134196698665619,
-0.09233742952346802,
-0.20196738839149475,
0.2979120910167694,
-0.34947848320007324,
0.0442429818212986,
-1.8772343397140503,
0.7693054676055908,
0.16990245878696442,
0.07986494153738022,
-0.07510924339294434,
0.2921419143676758,
0.20929166674613953,
-0.017331993207335472,
0.3859604299068451,
-0.17817088961601257,
-0.7138581275939941,
-0.3175329566001892,
0.350030779838562,
-0.4824724793434143,
0.10382946580648422,
-0.10089482367038727,
-0.6707104444503784,
0.23068417608737946,
-0.3379068970680237,
0.35390034317970276,
-0.0042327228002250195,
0.00282052019611001,
-0.6587015390396118,
0.06717352569103241,
0.29261159896850586,
-0.12132114917039871,
0.013543383218348026,
-0.20501874387264252,
-0.34720227122306824,
-0.07727804780006409,
-0.1991417557001114,
-0.01745508797466755,
0.065103679895401,
-0.447319358587265,
0.21935711801052094,
0.13088294863700867,
0.7236519455909729,
-0.14274455606937408,
0.09062093496322632,
-0.175361767411232,
-0.1781158745288849,
0.6672378778457642,
-0.5141243934631348,
-0.34593915939331055,
-0.5781616568565369,
0.07735960185527802,
0.6456692814826965,
0.37104126811027527,
0.11697568744421005,
0.2642085552215576,
0.13688412308692932,
-0.09915269166231155,
0.266080379486084,
0.44998303055763245,
-0.003311852226033807,
0.2016385793685913,
0.3795912265777588,
-0.2010359764099121,
-0.2371441274881363,
-0.12548384070396423,
-0.10568282753229141,
-0.5651601552963257,
-0.757442831993103,
0.31059321761131287,
-0.8720799088478088,
-0.0068251024931669235,
-0.04918280243873596,
-0.3144594728946686,
0.1765960305929184,
-0.14573200047016144,
-0.25889745354652405,
0.11742358654737473,
0.06888743489980698,
-0.2806713879108429,
0.23392461240291595,
1.0616140365600586,
-0.49314895272254944,
0.34295836091041565,
0.016753926873207092,
0.17104966938495636,
-0.1874469518661499,
-0.015897149220108986,
0.15699830651283264,
0.44724705815315247,
-0.07148388028144836,
0.3945622146129608,
-0.4974372088909149,
-0.13569791615009308,
0.13413822650909424,
0.22338184714317322,
0.2891078591346741,
0.0991457998752594,
0.3386182188987732,
0.3105587661266327,
-0.367032915353775,
-0.5242040753364563,
-0.41074585914611816,
-0.07961919158697128,
0.1742047518491745,
-0.11229975521564484,
-0.2037675976753235,
0.08314479887485504,
0.09669826179742813,
-0.11748702824115753,
-0.10380066931247711,
-0.42995133996009827,
-0.7271053194999695,
0.0029095083009451628,
-0.020362544804811478,
0.5012450218200684,
-0.2983459234237671,
-0.6067895889282227,
0.13967294991016388,
0.4625927209854126,
0.4894140958786011,
-0.23670808970928192,
-0.4081729054450989,
0.10919120907783508,
0.2417755275964737,
-0.06256966292858124,
0.2935040295124054,
0.29821497201919556,
0.23788855969905853,
-0.11414770781993866,
-0.18849210441112518,
-0.40342891216278076,
0.42344388365745544,
-0.4740850627422333,
0.5848960280418396,
0.07321595400571823,
0.1520794779062271,
0.132437065243721,
0.04319705069065094,
0.18254567682743073,
-1.0678297281265259,
-0.3276018500328064,
-0.015715796500444412,
-0.07036126405000687,
0.36768266558647156,
0.08854647725820541,
0.3893311321735382,
-0.14411978423595428,
-0.17176632583141327,
-0.2303462028503418,
-0.05377744883298874,
-0.14685915410518646,
0.5447424650192261,
-0.49197518825531006,
1.3122886419296265,
-0.32465898990631104,
-0.28573647141456604,
0.7153226137161255,
0.30309703946113586,
0.3856402039527893,
0.023431947454810143,
-0.3977123200893402,
0.6766229271888733,
0.28603920340538025,
0.004752629436552525,
0.23459386825561523,
-0.06557770818471909,
0.036612000316381454,
-0.06472241133451462,
0.19603580236434937,
0.19177086651325226,
-0.8297352194786072,
-0.08451022207736969,
0.2999681830406189,
0.36445218324661255,
-0.24225416779518127,
-0.039967991411685944,
-0.3309842646121979,
-0.7714084386825562,
-0.019749034196138382,
0.19516482949256897,
-0.2439626157283783,
0.3556627631187439,
0.7601525783538818,
-0.12052266299724579,
0.977202296257019,
0.8343361020088196,
0.4680083692073822,
0.930122435092926,
-0.5596461296081543,
0.08561770617961884,
-0.05219825729727745,
0.1134614571928978,
-0.19729319214820862,
0.08648403733968735,
0.08101032674312592,
0.30308443307876587,
0.10436189919710159,
0.16837097704410553,
0.06810115277767181,
-0.2078329175710678,
0.174955815076828,
-0.7030076384544373,
0.1766299158334732,
0.29663020372390747,
-0.3967273235321045,
-0.3391805589199066,
0.3889075815677643,
-1.0640912055969238,
-0.384289026260376,
0.29227831959724426,
0.08133810758590698,
0.15322133898735046,
-0.6159205436706543,
-0.0453798808157444,
0.07949277758598328,
0.08984658867120743,
-0.2311154305934906,
0.2483086735010147,
-0.5678772926330566,
-0.49989354610443115,
0.23258943855762482,
-0.04008607566356659,
0.15819528698921204,
0.04739406704902649,
-0.3437896966934204,
-0.35765591263771057,
-0.002436660695821047,
0.7875420451164246,
0.13772696256637573,
0.79288649559021,
-0.17837773263454437,
-0.7708454132080078,
0.1382475197315216,
-0.44833648204803467,
-0.293876051902771,
-0.3049165904521942,
0.591184139251709,
-0.46110883355140686,
-0.039718788117170334,
-0.20724010467529297,
0.43893003463745117,
0.3417046070098877,
0.11109083890914917,
-0.540391743183136,
0.26303568482398987,
-0.48032039403915405,
-0.41618454456329346,
-0.49968478083610535,
-0.5079073309898376,
-0.4314846694469452,
0.5814967155456543,
-0.2284620702266693,
0.3605700433254242,
0.26522770524024963,
0.37631484866142273,
0.2596011459827423,
0.20991723239421844,
0.4495721161365509,
-0.17927849292755127,
-0.06259343028068542,
0.390882670879364,
-0.0391702838242054,
0.15713046491146088,
-0.2739986479282379,
0.21593493223190308,
-0.5284605026245117,
0.45920276641845703,
-5.849549293518066,
0.20535141229629517,
-0.0472431443631649,
-0.12933002412319183,
0.0011784336529672146,
-0.2951340675354004,
0.8605243563652039,
0.04703338444232941,
0.5337613821029663,
0.4155590832233429,
0.11223066598176956,
0.385064959526062,
-0.21573929488658905,
0.20819054543972015,
-0.3417389392852783,
-0.17196257412433624,
-0.34913110733032227,
-0.7146540284156799,
0.44827887415885925,
0.265892893075943,
0.12572158873081207,
-0.07096932083368301,
-0.1577216237783432,
0.6027313470840454,
-0.22263306379318237,
0.06192930415272713,
-0.31318140029907227,
-0.06329457461833954,
-0.1726336032152176,
-0.6143252849578857,
0.2226589173078537,
-0.5990868806838989,
0.03496650606393814,
0.10555636882781982,
0.38624826073646545,
0.07141400873661041,
0.18220174312591553,
-0.1277419626712799,
-0.35007965564727783,
-0.5042725205421448,
0.06208121404051781,
0.04965408146381378,
-0.26413026452064514,
0.2581377327442169,
0.2803233563899994,
0.059848181903362274,
-0.12270352989435196,
0.39664486050605774,
-0.45329222083091736,
0.7139940857887268,
-0.0228109210729599,
-0.26435020565986633,
0.17062285542488098,
0.7500107288360596,
0.5936583280563354,
0.2605414390563965,
0.24249452352523804,
-0.2400975525379181,
-0.05147065594792366,
0.138357475399971,
-0.048072073608636856,
0.04445026442408562,
-0.8553152680397034,
-0.29325559735298157,
0.10648952424526215,
0.40670663118362427,
-0.33948376774787903,
-0.2570400834083557,
0.7454072833061218,
-0.4417847692966461,
-0.19978107511997223,
0.10885580629110336,
0.1860782504081726,
-0.7670454382896423,
0.6791114807128906,
-0.14758120477199554,
0.3367285430431366,
0.03954792395234108,
-0.05075301602482796,
0.05042950436472893,
-0.382487416267395,
-0.1115570068359375,
-0.11800354719161987,
-0.1452709436416626,
0.25298675894737244,
-0.4571773111820221,
0.04646871238946915,
0.5988318920135498,
0.6342418789863586,
0.44896993041038513,
0.9918820858001709,
-0.06114983558654785,
0.10584727674722672,
0.3434332311153412,
0.13463254272937775,
0.6477770805358887,
0.46238479018211365,
0.7707529067993164,
0.49793773889541626,
0.15991944074630737,
0.4355080723762512,
-0.0878913477063179,
-0.16797152161598206,
-0.8299453258514404,
-0.4778706729412079,
0.4258354902267456,
-0.6253905892372131,
0.09676432609558105,
0.49080121517181396,
-0.7710806727409363,
-0.018595032393932343,
0.0134056331589818,
-0.47371533513069153,
-0.2193087786436081,
0.7146042585372925,
-0.43902212381362915,
0.18308871984481812,
0.30312076210975647,
0.5298526883125305,
-0.3438953757286072,
0.0413619801402092,
0.3983623683452606,
-0.7091779708862305,
0.1942644566297531,
0.24346429109573364,
0.08718957751989365,
-0.36718395352363586,
0.6757851839065552,
-0.34271782636642456,
-0.4276457726955414,
0.4302179515361786,
0.3140701353549957,
-0.13005496561527252,
0.38885095715522766,
0.20196689665317535,
-0.9867606163024902,
-0.13258232176303864,
0.5375269651412964,
0.19742517173290253,
-0.29342877864837646,
0.8055189251899719,
-0.2556703984737396,
-0.26513001322746277,
-0.3878742456436157,
0.2822844088077545,
-0.1758839190006256,
-0.2898676097393036,
0.003265991108492017,
-0.38399335741996765,
0.08135303109884262,
0.20817847549915314,
-0.21012800931930542,
-0.1853087842464447,
0.29079943895339966,
-0.35837602615356445,
0.763897716999054,
0.0335969477891922,
-0.17187030613422394,
0.242094025015831,
-0.5732717514038086,
0.20521655678749084,
0.25857874751091003,
-0.7139445543289185,
0.0487847700715065,
-0.10395786911249161,
-0.05285557359457016,
-0.04952772334218025,
-0.9137857556343079,
0.09319043159484863,
0.40863466262817383,
-0.35707199573516846,
0.104607492685318,
-0.3527461886405945,
-0.06466946750879288,
0.2651256322860718,
-0.5022432208061218,
-0.4925925135612488,
-0.1463802009820938,
0.21488961577415466,
0.05566667020320892,
0.010318176820874214,
-0.4742586016654968,
-0.029557175934314728,
0.14327767491340637,
0.4868955910205841,
-0.35682347416877747,
0.059494748711586,
-0.30286863446235657,
-0.07511598616838455,
-0.6672725677490234,
0.21609064936637878,
0.10027914494276047,
0.2303081601858139,
-0.30481094121932983,
0.149496391415596,
0.30281302332878113,
0.19658422470092773,
0.3171433210372925,
0.0428331084549427,
-0.6613548398017883,
-0.1428367793560028,
-0.03471236303448677,
-0.3697907030582428,
0.22285719215869904,
0.8125346899032593,
-0.06843619048595428,
-0.13933323323726654,
0.12823110818862915,
-0.34531503915786743,
-0.08121360838413239,
-0.12531547248363495,
-0.7960526347160339,
-0.1421273797750473,
-0.01302632037550211,
-0.02871282771229744,
-0.11263906955718994,
0.018672414124011993,
-0.7459853291511536,
-0.5450138449668884,
0.6654065847396851,
0.223676860332489,
-0.13463148474693298,
-0.01271700207144022,
0.12661567330360413,
-0.6482654213905334,
-0.6759729981422424,
0.211347296833992,
-0.46043598651885986,
0.7350271344184875,
-0.11860846728086472,
0.04708951711654663,
0.19437482953071594,
0.186889186501503,
0.36193719506263733,
-0.2762177586555481,
-0.3317101001739502,
-0.323825478553772,
0.5533555746078491,
0.02197110466659069,
0.7494582533836365,
0.36943525075912476,
0.29185307025909424,
-0.42938870191574097,
0.21120959520339966,
-0.21175464987754822,
0.22473415732383728,
-0.032975759357213974,
-0.3786574602127075,
-0.39949044585227966,
0.3553755581378937,
0.5440893769264221,
-0.0372043140232563,
0.31197023391723633,
0.4874986708164215,
0.715331494808197,
-0.36586079001426697,
0.18212707340717316,
-0.7476282715797424,
-0.4224684238433838,
0.0898180678486824,
-0.4836445152759552,
-0.19442901015281677,
0.5059114098548889,
0.17646223306655884,
-0.029744215309619904,
0.08864147961139679,
-0.26344549655914307,
-1.099853515625,
0.7782066464424133,
0.04729372262954712,
-0.0009508993243798614,
-0.4767274856567383,
0.43266549706459045,
0.15396998822689056,
-0.26797205209732056,
-0.01757725141942501,
-0.33999404311180115,
-0.09217239171266556,
0.022061053663492203,
0.290195494890213,
0.10668905824422836,
-0.24638815224170685,
0.02089320309460163,
-0.6481123566627502,
0.1210351511836052,
-1.0510680675506592,
0.44819241762161255,
-0.4759269058704376,
0.09029250591993332,
-0.1036662682890892,
-0.5626363754272461,
0.5232729911804199,
-0.4438640773296356,
-0.34798359870910645,
-0.3241477310657501,
0.09832073003053665,
-0.07815992087125778,
0.449383020401001,
-0.17756450176239014,
0.16115887463092804,
-0.1818980872631073,
0.3041371703147888,
0.552695631980896,
-0.1640317589044571,
-0.01733642816543579,
0.633743405342102,
-0.301839143037796,
-0.3079514503479004,
-0.5796394944190979,
-0.31828543543815613,
-0.2713114619255066,
-0.35026878118515015,
0.43587324023246765,
-0.03985003009438515,
-0.08550772070884705,
0.515160858631134,
-0.10866356641054153,
0.0647597461938858,
0.11190799623727798,
0.36573326587677,
0.44418224692344666,
0.8188489675521851,
0.25793617963790894,
-0.2528091073036194,
-0.07970693707466125,
0.29281917214393616,
0.4809151291847229,
0.1775796115398407,
0.5436309576034546,
0.7697252631187439,
0.231301948428154,
-0.09091834723949432,
0.2280844748020172,
1.1593033075332642,
0.454377144575119,
0.004744307138025761,
0.6786435842514038,
-0.9193391799926758,
-0.104667529463768,
-0.4840408265590668,
0.5305569171905518,
0.5663273930549622,
-0.01450830977410078,
-0.1747589111328125,
0.2701895833015442,
0.6282010078430176,
0.05940578877925873,
0.39547809958457947,
-0.3096487522125244,
-0.0438963957130909,
0.23222622275352478,
-0.5799093842506409,
-0.3865751028060913,
0.08173346519470215,
-0.463015615940094,
0.31216713786125183,
0.13669127225875854,
-0.35556498169898987,
-0.4418737292289734,
0.22210291028022766,
-0.3013180196285248,
-0.19491241872310638,
0.05773254111409187,
0.35590341687202454,
-0.08271857351064682,
-0.2606057822704315,
0.2411399483680725,
0.35384777188301086,
0.5040966272354126,
0.014608455821871758,
-0.3548472225666046,
0.04487203434109688,
0.19704560935497284,
0.21352964639663696,
0.3316138982772827,
-0.33152109384536743,
0.3193414509296417,
-0.31031832098960876,
0.03210369125008583,
0.5433573126792908,
-0.48328644037246704,
0.18542730808258057,
-0.5629026293754578,
-0.34971994161605835,
-0.22625763714313507,
-0.6284050941467285,
-0.49329084157943726,
0.2711050510406494,
-0.3399607241153717,
0.06249046325683594,
-0.33322784304618835,
-0.3328230082988739,
0.1379380226135254,
-0.22028416395187378,
0.44908836483955383,
0.00045716448221355677,
-0.07586593925952911,
-0.041599027812480927,
0.2081943154335022,
0.6979725360870361,
0.15202102065086365,
0.028582943603396416,
-0.19365373253822327,
0.32622140645980835,
-1.0217753648757935,
0.7969827651977539,
-0.180520698428154,
-0.12316371500492096,
-0.3357168436050415,
-0.35914796590805054,
0.8547287583351135,
0.8466789722442627,
-0.050460800528526306,
0.07696141302585602,
0.2211029976606369,
0.12334012985229492,
0.606564998626709,
-0.19341985881328583,
-0.404985249042511,
-0.6709486842155457,
-0.11389382928609848,
-0.3421061635017395,
0.7348770499229431,
-0.16233627498149872,
-0.498884916305542,
0.11657900363206863,
0.9224513173103333,
0.24576246738433838,
-0.14870314300060272,
-0.12365297228097916,
-0.28736424446105957,
-0.09092848002910614,
-0.4420059025287628,
0.37539517879486084,
-0.6287873983383179,
-0.2276180386543274,
-0.24329255521297455,
-0.15682120621204376,
-0.2003999799489975,
-0.22760264575481415,
0.18047088384628296,
-0.48010581731796265,
-0.047162268310785294,
-0.0314798578619957,
-0.005133959464728832,
-0.3353598713874817,
-0.06753313541412354,
-0.6614601016044617,
-0.1787141114473343,
0.374416708946228,
0.10819143801927567,
-0.6821597218513489,
-0.1614861786365509,
0.04758058860898018,
-0.011899037286639214,
0.1185482069849968,
-0.06929857283830643,
-0.21008095145225525,
-0.48596513271331787,
-0.09887818247079849
] |
Background Compared to other European countries, Sweden's yearly sick leave expenditures are moderate. Common mental disorders (CMD) are important causes of sick leave, affecting 10-15% of the adult population. A Swedish register based study indicates that antidepressant therapy for patients on long-term sick leave for CMD leads to longer sick leave and higher frequency of non-time-limited sickness compensation as compared to psychotherapy, work oriented rehabilitation, and other therapies. Aim To verify if patients on antidepressant therapy and on long-term sick leave for depression, anxiety and stress-related mental disorders have a longer sick leave than patients treated with other therapies. Method Prospective, observational study at 28 primary health care centers in the Region Västra Götaland, Sweden, including 192 patients on sick leave for CMD. Outcome measures were gross and net sick leave days. Interpretation There were no significant differences in sick leave days (gross or net) due to CMD when comparing the patients treated and not treated with antidepressants during the 12 month observation period. The groups differed at baseline only concerning frequency of exhaustion disorder, with a higher frequency of exhaustion disorder in the group without antidepressants. Analysis of other possible factors associated with shorter or longer sick leave only showed associations with the patient's own perception of possibility of returning to work in near and distant future. An important factor associated with longer sick leave was the patient's own perception of possibility of return to present workplace. As CMD are important causes of sick leave and sick leave costs, this factor should be highlighted in future research on the rehabilitation process. | [
0.016919000074267387,
0.005139182321727276,
-0.01190455723553896,
0.015575089491903782,
0.00629389425739646,
-0.01792527176439762,
0.010450318455696106,
0.0037608451675623655,
-0.010722278617322445,
-0.026170745491981506,
-0.017530694603919983,
0.016286788508296013,
-0.005123132839798927,
0.021738262847065926,
-0.0007336384151130915,
0.007270608562976122,
-0.03441186249256134,
0.044443000108003616,
0.011436219327151775,
0.0026396908797323704,
-0.003692926373332739,
-0.04505068063735962,
0.010119449347257614,
-0.006847127340734005,
0.002300858497619629,
0.011524834670126438,
-0.004328964743763208,
0.0020278235897421837,
0.02734745852649212,
0.008160226047039032,
-0.03943299502134323,
0.007358169183135033,
0.01904233917593956,
0.026263771578669548,
0.01637619361281395,
0.021453341469168663,
-0.00019803026225417852,
0.02954983152449131,
-0.005793622694909573,
-0.00490335188806057,
0.01505163311958313,
-0.00828658975660801,
0.006093348376452923,
-0.006599494721740484,
-0.005575196817517281,
0.008875599130988121,
-0.010430634021759033,
-0.024585740640759468,
0.004119005985558033,
0.012223253957927227,
-0.01709877885878086,
-0.01937216892838478,
-0.01262638159096241,
-0.05336533859372139,
-0.007044326979666948,
-0.005259370896965265,
0.0183168463408947,
0.02693784609436989,
0.00513396505266428,
-0.025034090504050255,
0.010224591009318829,
-0.009174360893666744,
0.008511039428412914,
0.020347483456134796,
0.021998804062604904,
-0.06662285327911377,
0.014265572652220726,
-0.007334447465837002,
0.012939799576997757,
0.012577557004988194,
0.010183729231357574,
0.005885339342057705,
0.014878490008413792,
-0.00853187870234251,
-0.019657615572214127,
0.021054832264780998,
0.03066728264093399,
0.023338185623288155,
0.005026595667004585,
-0.006764872465282679,
-0.008584735915064812,
-0.015991581603884697,
-0.0026987046003341675,
0.015153417363762856,
-0.04309681057929993,
-0.010297026485204697,
-0.014919783920049667,
-0.02126455493271351,
-0.012605844996869564,
0.012014945968985558,
0.003748832270503044,
0.01222221553325653,
-0.017574451863765717,
0.02090933732688427,
-0.00023487862199544907,
-0.03290443867444992,
-0.009416216984391212,
0.014867020770907402,
-0.008934401907026768,
-0.0182080939412117,
-0.0018633482977747917,
-0.005029685795307159,
0.01212186086922884,
-0.0028904620558023453,
-0.014344233088195324,
0.006847307085990906,
-0.022973518818616867,
0.0003727921284735203,
-0.014892877079546452,
0.009680680930614471,
-0.024724630638957024,
0.020372632890939713,
0.03115035779774189,
0.006156112067401409,
0.004320769105106592,
-0.001698964275419712,
-0.0046932813711464405,
0.014487436041235924,
0.009144600480794907,
-0.0074257152155041695,
-0.009657355956733227,
0.024462565779685974,
0.0013603692641481757,
-0.004571482073515654,
-0.0016529011772945523,
0.03165705129504204,
0.0034745351877063513,
0.0018298500217497349,
-0.01850946433842182,
-0.004478578455746174,
-0.007439993321895599,
0.0125101488083601,
-0.023846272379159927,
0.013166232965886593,
0.010988874360918999,
-0.006378235295414925,
-0.025112316012382507,
0.011060021817684174,
0.002392935799434781,
-0.04052232205867767,
-0.01871477998793125,
0.011778662912547588,
-0.007809480652213097,
0.005610775202512741,
0.006833796389400959,
-0.017572293058037758,
0.03338613361120224,
0.012274439446628094,
-0.021195784211158752,
0.030878258869051933,
-0.005445210263133049,
0.02481253445148468,
0.02783835120499134,
-0.01472768560051918,
-0.030837947502732277,
0.0035050739534199238,
-0.015401527285575867,
-0.0007721344009041786,
-0.002509309444576502,
0.00406993692740798,
-0.005776532925665379,
-0.033123619854450226,
-0.004851324483752251,
0.008197082206606865,
0.019904304295778275,
0.016253292560577393,
0.012202653102576733,
-0.007260184269398451,
0.02305326983332634,
0.010139184072613716,
-0.006579909473657608,
-0.0025768911000341177,
-0.012516701593995094,
0.01255602203309536,
0.003292483277618885,
0.00211672717705369,
0.004742971621453762,
0.01025056280195713,
0.0016288268379867077,
0.0663595199584961,
-0.024828333407640457,
-0.0019605676643550396,
0.014010915532708168,
-0.04193742573261261,
0.014712163247168064,
-0.003623322118073702,
0.0313359797000885,
-0.011401774361729622,
-0.007196936756372452,
0.012851915322244167,
-0.00022727204486727715,
0.02671843208372593,
0.011908531188964844,
0.025127623230218887,
-0.01556301862001419,
0.005998336710035801,
0.011345861479640007,
-0.001415926730260253,
-0.020252471789717674,
0.009156126528978348,
0.034421179443597794,
-0.028106415644288063,
0.02335728146135807,
-0.014757409691810608,
0.019699085503816605,
0.024215079843997955,
0.0160836074501276,
0.03678120672702789,
0.004317832179367542,
-0.016901928931474686,
0.017890892922878265,
0.00026457977946847677,
0.018423648551106453,
0.01330037135630846,
0.014025023207068443,
-0.009405883960425854,
-0.018100742250680923,
0.011722506955265999,
0.0011417340720072389,
-0.015401792712509632,
0.00378363742493093,
-0.003572414629161358,
-0.03883946314454079,
0.005701108835637569,
0.0031770411878824234,
-0.021904099732637405,
0.0033613063860684633,
0.0032455073669552803,
-0.012921586632728577,
0.013493996113538742,
-0.005058726295828819,
-0.006828040350228548,
-0.008175639435648918,
0.0017749764956533909,
-0.046745650470256805,
0.02755143865942955,
0.009473670274019241,
0.00903332605957985,
0.01838337816298008,
-0.02224561758339405,
0.010092094540596008,
-0.0016156153287738562,
-0.0295006912201643,
0.011374838650226593,
0.017297131940722466,
0.008171005174517632,
-0.009451276622712612,
-0.01113671250641346,
0.008438024669885635,
-0.01495455577969551,
0.00774762686342001,
-0.01427561417222023,
0.0066137355752289295,
-0.003820037003606558,
-0.0016343255992978811,
-0.009648018516600132,
0.013763252645730972,
-0.02473326027393341,
0.026821421459317207,
-0.028651162981987,
0.012399151921272278,
0.012507762759923935,
-0.007614135276526213,
-0.007746666204184294,
-0.012939641252160072,
-0.006827374454587698,
0.0044236741960048676,
-0.015670055523514748,
0.012166045606136322,
0.009009037166833878,
0.008153184317052364,
-0.008535395376384258,
-0.004161101300269365,
-0.0816744789481163,
-0.013232187367975712,
0.03601761907339096,
-0.007329247891902924,
0.005896603688597679,
-0.029246626421809196,
-0.0016424106433987617,
0.012430379167199135,
-0.01130216009914875,
-0.004992888309061527,
0.010659618303179741,
0.0167604461312294,
0.0004892704891972244,
-0.00021214131265878677,
0.012185435742139816,
-0.011977747082710266,
0.0022487302776426077,
0.040443725883960724,
-0.014461137354373932,
-0.021394595503807068,
0.016585372388362885,
-0.024022221565246582,
0.028339890763163567,
0.0006986946100369096,
-0.028857041150331497,
0.0434560626745224,
0.013008980080485344,
-0.013851629570126534,
0.005275427363812923,
0.004113184753805399,
-0.03171283379197121,
0.009783263318240643,
0.002127721905708313,
0.0002979668788611889,
-0.05469522625207901,
-0.001427177106961608,
-0.03249097615480423,
0.000956396572291851,
-0.004997831769287586,
-0.004136652685701847,
0.012865197844803333,
0.0038100644014775753,
0.03059198148548603,
0.003930176142603159,
0.008063367567956448,
0.014137723483145237,
0.030170679092407227,
0.02347259782254696,
0.009638150222599506,
-0.012787628918886185,
-0.025070928037166595,
-0.002108273096382618,
0.008282230235636234,
0.007771935313940048,
-0.012481660582125187,
-0.03659896180033684,
-0.018684720620512962,
0.026002580299973488,
-0.015840398147702217,
-0.00585542805492878,
-0.019506830722093582,
-0.02786242589354515,
0.03360787779092789,
0.004984941333532333,
0.0395195297896862,
-0.016434043645858765,
-0.001366934971883893,
0.007307755760848522,
-0.016309421509504318,
0.010054783895611763,
-0.005238654557615519,
-0.021515535190701485,
-0.0053971498273313046,
-0.004805091768503189,
0.021881580352783203,
-0.008595075458288193,
-0.01455996185541153,
0.00816897302865982,
0.027352452278137207,
0.0005818007048219442,
0.006893537472933531,
-0.006968013942241669,
0.0099418880417943,
0.0035742332693189383,
-0.005969435907900333,
0.008368615992367268,
0.007746471092104912,
-0.011699872091412544,
0.007886925712227821,
-0.02126202918589115,
-0.0023054704070091248,
0.04327947646379471,
0.006264363881200552,
0.0064665814861655235,
-0.005054224748164415,
0.006263274699449539,
0.02866421267390251,
-0.004176443442702293,
0.0020444272086024284,
0.011492811143398285,
-0.002141473814845085,
-0.0052778166718780994,
-0.032409414649009705,
-0.008708675391972065,
0.00909415166825056,
0.01753579080104828,
0.01626472920179367,
-0.007154928985983133,
-0.03383580967783928,
-0.004409505054354668,
0.005821935832500458,
-0.014691776596009731,
-0.008471609093248844,
0.019592372700572014,
0.010821403004229069,
0.00650895806029439,
0.02406565472483635,
0.0012586349621415138,
0.07165177166461945,
0.012052825652062893,
0.01210055686533451,
-0.007280836347490549,
0.012071299366652966,
-0.01786438375711441,
-0.024690134450793266,
0.017362335696816444,
0.0086681442335248,
0.003214837284758687,
0.01430727168917656,
0.022463906556367874,
-0.009347815066576004,
0.00014988798648118973,
-0.005179268307983875,
-0.005647785495966673,
-0.03753850981593132,
-0.007682160474359989,
-0.0018143134657293558,
-0.010013606399297714,
0.016557803377509117,
-0.000377502990886569,
-0.01559101976454258,
0.0029377033933997154,
0.014528242871165276,
-0.014936555176973343,
0.015653595328330994,
-0.013350307941436768,
-0.011570971459150314,
-0.0006762242410331964,
-0.019271356984972954,
0.03047051653265953,
0.0006789455655962229,
0.025571973994374275,
0.007121486589312553,
0.005711717065423727,
-0.013597993180155754,
-0.01638943701982498,
-0.0001335632987320423,
-0.001799537567421794,
0.0025730866473168135,
-0.018928825855255127,
-0.03683669865131378,
0.0018886220641434193,
-0.008874555118381977,
0.017522413283586502,
0.02551695704460144,
-0.0086372634395957,
-0.01552694384008646,
0.01317782886326313,
0.0010427739471197128,
0.019596263766288757,
0.007658390328288078,
0.019773753359913826,
-0.0023476649075746536,
-0.002965607214719057,
-0.016537684947252274,
-0.006741042248904705,
-0.007173452526330948,
0.029476474970579147,
-0.0006433181697502732,
-0.017104843631386757,
0.004912374075502157,
-0.006380395032465458,
-0.014837988652288914,
-0.012056789360940456,
-0.03780108690261841,
0.000016862759366631508,
0.007423317991197109,
-0.06169012933969498,
-0.001297665061429143,
-0.03911709040403366,
0.017931437119841576,
0.014452977105975151,
-0.017162814736366272,
-0.019658587872982025,
-0.04094269126653671,
0.0017718116287142038,
0.004898533690720797,
-0.024180445820093155,
-0.019784215837717056,
-0.01572338305413723,
-0.0016559036448597908,
-0.001439673826098442,
-0.007183612324297428,
-0.01347880158573389,
0.012853747233748436,
-0.07445108890533447,
-0.009892651811242104,
0.016899531707167625,
-0.0139760822057724,
0.022177357226610184,
-0.01607484742999077,
-0.006030485965311527,
-0.0021510301157832146,
0.0306681077927351,
-0.003166590351611376,
0.027346603572368622,
-0.014684079214930534,
-0.024318717420101166,
-0.018390856683254242,
0.014257466420531273,
-0.007011063862591982,
-0.009229423478245735,
0.0006742645055055618,
-0.0032787963282316923,
0.014078877866268158,
0.023784330114722252,
0.02933141216635704,
-0.007240166887640953,
0.009230994619429111,
0.006581510417163372,
-0.08072805404663086,
-0.0000726780854165554,
-0.024654755368828773,
-0.008522862568497658,
-0.016388723626732826,
0.0026765838265419006,
0.011428836733102798,
-0.00823743175715208,
-0.046138741075992584,
-0.018601499497890472,
0.014262165874242783,
-0.005583355203270912,
0.02343836799263954,
-0.02492804080247879,
0.011253026314079762,
-0.011915844865143299,
0.01405540481209755,
0.0052950941026210785,
-0.024247920140624046,
-0.04495071619749069,
0.00728768203407526,
0.023967863991856575,
-0.003569039050489664,
0.0073776887729763985,
-0.004075032193213701,
-0.023547934368252754,
0.003402277361601591,
0.009703442454338074,
0.018541697412729263,
-0.02639298141002655,
0.017410501837730408,
-0.014443914406001568,
0.009287702850997448,
-0.02656630426645279,
0.002042456530034542,
-0.02072187513113022,
-0.0019250379409641027,
0.009975485503673553,
-0.006018784828484058,
-0.006765370257198811,
-0.013802412897348404,
0.01493295282125473,
0.011879421770572662,
0.011768823489546776,
-0.013293849304318428,
-0.0005944753065705299,
0.009626749902963638,
-0.010440947487950325,
0.00872623547911644,
0.012940444052219391,
0.011714848689734936,
0.0024237511679530144,
-0.002917282283306122,
0.03511644899845123,
-0.013940159231424332,
-0.013061068952083588,
-0.011706316843628883,
0.015470227226614952,
0.011375139467418194,
-0.002955066505819559,
0.000821039080619812,
-0.022572437301278114,
0.011654085479676723,
0.07137566804885864,
-0.0037259869277477264,
0.023488212376832962,
-0.01048610545694828,
0.002321684267371893,
-0.0021731641609221697,
-0.013711433857679367,
-0.012075778096914291,
-0.028597813099622726,
0.01031995378434658,
0.004352059680968523,
-0.007702945731580257,
0.013056267984211445,
0.01625935360789299,
0.003937762230634689,
-0.007739641238003969,
0.01158299669623375,
0.020226364955306053,
0.0011816679034382105,
0.01270096655935049,
0.02216401696205139,
-0.015151480212807655,
-0.0021477346308529377,
-0.0025534131564199924,
0.00956272054463625,
0.00042434874922037125,
-0.006700905971229076,
0.005399074871093035,
-0.007177738472819328,
0.02207157574594021,
-0.014045528136193752,
-0.0011190949007868767,
0.004458793438971043,
0.0036996002309024334,
0.015134175308048725,
0.0072066280990839005,
0.003367904108017683,
0.0008770471904426813,
-0.000006601912900805473,
0.03379489481449127,
-0.05215658247470856,
-0.027852004393935204,
0.010029807686805725,
-0.0167667455971241,
0.005677319131791592,
-0.016336096450686455,
-0.0012804260477423668,
-0.014149575494229794,
-0.023135587573051453,
0.010345246642827988,
0.00015294644981622696,
0.0005829486763104796,
-0.002548724412918091,
0.0024984311312437057,
0.02198033407330513,
0.051393307745456696,
-0.026849918067455292,
0.016619304195046425,
-0.017673185095191002,
-0.02697625756263733,
-0.004353000782430172,
-0.015315626747906208,
0.03490952402353287,
-0.0034051877446472645,
-0.008672324009239674,
0.03372624143958092,
0.013745585456490517,
0.0038656103424727917,
-0.026763882488012314,
0.01361103169620037,
-0.01510742399841547,
-0.001346370205283165,
0.01401636004447937,
-0.011472499929368496,
-0.012851910665631294,
0.026681262999773026,
0.0234826747328043,
-0.02916659787297249,
0.0057967593893408775,
0.0016394553240388632,
-0.015615910291671753,
-0.005970375146716833,
-0.001437176251783967,
0.012211567722260952,
0.026415089145302773,
-0.005422613583505154,
-0.027613569051027298,
0.02718234993517399,
-0.019265491515398026,
0.004525694064795971,
0.030259639024734497,
0.01131600234657526,
-0.006843041628599167,
0.016333598643541336,
0.01792474091053009,
0.03578927367925644,
0.024953950196504593,
0.0010954614263027906,
0.022680673748254776,
-0.0022844464983791113,
-0.013705214485526085,
-0.008456580340862274,
0.012806610204279423,
-0.007991647347807884,
0.0013436049921438098,
-0.014428176917135715,
0.015794452279806137,
-0.008828515186905861,
-0.026037713512778282,
0.017664413899183273,
-0.016775526106357574,
0.006667713634669781,
0.02630460634827614,
0.03319098800420761,
0.004373772069811821,
0.004561368841677904,
-0.013188724406063557,
-0.004749513231217861,
0.022086508572101593,
-0.009541302919387817,
0.014768548309803009,
0.004065216053277254,
0.010116301476955414,
0.021626412868499756,
0.02784302458167076,
-0.03566603362560272,
-0.011438076384365559,
0.01077365130186081,
-0.029932435601949692,
-0.002945643849670887,
0.003003237070515752,
0.0047906143590807915,
-0.0072570666670799255,
0.0039944518357515335,
-0.008610076270997524,
-0.0017308006063103676,
0.036491941660642624,
0.05025186389684677,
-0.0018691241275519133,
-0.012163311243057251,
0.03051038831472397,
-0.018051711842417717,
0.00352000305429101,
-0.026942266151309013,
0.00886981189250946,
-0.009158868342638016,
0.005854994989931583,
-0.0036885698791593313,
0.018706850707530975,
-0.00768622849136591,
-0.001165026449598372,
0.012883217073976994,
0.0029432529117912054,
-0.005347674712538719,
0.009465662762522697,
0.0240620169788599,
0.019920680671930313,
0.009929344058036804,
0.009990952908992767,
0.0026151794008910656,
0.008128184825181961,
-0.022540127858519554,
-0.00333597743883729,
0.012486446648836136,
-0.00515733053907752,
0.005104535259306431,
-0.031456172466278076,
0.0075127482414245605,
-0.014952627941966057,
0.016696447506546974,
-0.023331962525844574,
0.0061623044312000275,
0.005830247886478901,
0.009963947348296642,
-0.013190087862312794,
0.00043801916763186455,
0.023832421749830246,
0.001957113854587078,
-0.015065131708979607,
0.0015678033232688904,
0.0009030078072100878,
0.009235726669430733,
-0.0012890114448964596,
-0.009225845336914062,
-0.014447009190917015,
-0.0013276815880089998,
-0.00007958122296258807,
-0.026127003133296967,
-0.00822865404188633,
-0.014056091196835041,
0.009785020723938942,
-0.009312331676483154,
-0.006489819847047329,
-0.023276319727301598,
0.0002654753625392914,
0.018955618143081665,
0.0062339650467038155,
0.01502118818461895,
0.0023804802913218737,
0.0067901210859417915,
-0.0036175893619656563,
-0.03183184564113617
] | [
0.47247058153152466,
-0.1898517906665802,
0.22423510253429413,
0.030740931630134583,
-0.034496355801820755,
0.2683778703212738,
0.3752296268939972,
0.44976046681404114,
-1.031881332397461,
-0.16781949996948242,
0.21723178029060364,
0.11661577224731445,
0.13652397692203522,
-0.23593920469284058,
-0.4318821430206299,
0.5473493337631226,
0.7171574831008911,
0.6925209760665894,
-0.21764974296092987,
-0.5649542808532715,
-0.3521517813205719,
0.18827542662620544,
1.0732479095458984,
0.09796006232500076,
0.10787330567836761,
-0.17516548931598663,
0.5444751381874084,
0.1658530831336975,
-0.28005966544151306,
-0.18816082179546356,
-0.331932932138443,
0.4601728618144989,
0.15376067161560059,
0.13191024959087372,
0.41292378306388855,
-0.10304603725671768,
0.021832134574651718,
-0.12158051878213882,
0.2338562160730362,
-0.1242142990231514,
-0.3649430572986603,
-0.13118276000022888,
-0.3210617005825043,
0.43895041942596436,
0.06052177771925926,
-0.7326051592826843,
-1.2232197523117065,
0.5031524300575256,
0.026706628501415253,
0.288645476102829,
-0.13063448667526245,
0.28064700961112976,
0.1570882946252823,
0.43052056431770325,
0.09923476725816727,
-0.02404896169900894,
-0.36582431197166443,
0.1089898943901062,
-0.0712183341383934,
-0.2752072215080261,
0.06000925600528717,
-0.19844742119312286,
-0.2460649162530899,
-0.14468589425086975,
0.1246820017695427,
0.28876346349716187,
0.06255976855754852,
0.06942403316497803,
0.09310071915388107,
-0.4847610294818878,
0.051040031015872955,
-0.35108721256256104,
-0.3656049966812134,
-0.2363141030073166,
-0.06313099712133408,
-0.05413845553994179,
-0.02535064145922661,
-0.15300822257995605,
0.3180374205112457,
-0.542453944683075,
0.14631801843643188,
-0.22438423335552216,
0.5039041042327881,
-0.37640291452407837,
0.3434198796749115,
0.14955003559589386,
0.030424904078245163,
0.38443589210510254,
-0.056986529380083084,
-0.08688899129629135,
0.29519569873809814,
-0.22936344146728516,
0.6900967359542847,
0.8694990873336792,
-0.32339590787887573,
0.6692021489143372,
0.18544305860996246,
0.2855857312679291,
0.16582439839839935,
0.1957157850265503,
-0.024156037718057632,
0.3024246096611023,
0.14465183019638062,
-0.08505620807409286,
-0.1347409188747406,
-0.25571581721305847,
-0.057320695370435715,
0.0332975834608078,
-0.6683765649795532,
0.16451707482337952,
-0.7630117535591125,
0.04872109740972519,
-0.12188707292079926,
-0.05788721889257431,
0.0777401477098465,
0.05827372148633003,
0.002115164417773485,
-0.5984942317008972,
0.07393797487020493,
0.3248109817504883,
-0.0027331362944096327,
0.5519747734069824,
-0.148647278547287,
0.19030548632144928,
0.19016209244728088,
0.25222253799438477,
0.3131774365901947,
0.2802562415599823,
-0.004298826213926077,
0.3456205427646637,
0.5816933512687683,
0.2737289369106293,
-0.6135915517807007,
0.17840714752674103,
0.013833878561854362,
-0.304202675819397,
0.43955835700035095,
0.5894567370414734,
0.09601964801549911,
0.06500467658042908,
-0.6332870721817017,
-0.48725032806396484,
-0.0952884703874588,
-0.19384372234344482,
0.07625812292098999,
-0.8477146029472351,
-0.17209677398204803,
-0.42997604608535767,
-0.15721255540847778,
-0.12084130942821503,
0.16750483214855194,
0.03245700150728226,
-0.24755346775054932,
-0.20975492894649506,
0.14256185293197632,
0.38063061237335205,
0.10683800280094147,
-0.35053303837776184,
0.24391542375087738,
-0.05071769282221794,
0.49889346957206726,
0.21907947957515717,
-0.10273552685976028,
-0.10109435766935349,
0.37770381569862366,
0.141927108168602,
0.07577423006296158,
0.09385254234075546,
0.09651872515678406,
0.3969883620738983,
-0.5914149880409241,
0.23773542046546936,
0.0871998742222786,
-0.5488918423652649,
0.1470995992422104,
0.2656771242618561,
-0.018072297796607018,
0.19741477072238922,
0.031393710523843765,
0.11999165266752243,
-0.7183324694633484,
0.37785226106643677,
0.12346510589122772,
-0.6368713974952698,
0.027706535533070564,
0.06330569088459015,
0.10964495688676834,
0.21506883203983307,
0.274118572473526,
-0.3858812153339386,
-0.24623192846775055,
-0.561513364315033,
0.8100107908248901,
-0.25830382108688354,
1.058039903640747,
-0.4960881173610687,
-0.22448046505451202,
0.971720814704895,
0.22571058571338654,
-0.010407858528196812,
-0.3817918598651886,
-0.010736017487943172,
0.2533937692642212,
-0.14288552105426788,
-0.7130047678947449,
0.10611990094184875,
0.09137183427810669,
0.11781013011932373,
-0.10304360091686249,
-0.012456192634999752,
0.6957772374153137,
-0.6488023996353149,
-0.19249984622001648,
-0.2259022742509842,
-0.06902578473091125,
0.18977682292461395,
-0.14820216596126556,
0.052584707736968994,
0.14289262890815735,
0.30974820256233215,
0.2381652295589447,
-0.1389080286026001,
0.26805585622787476,
0.5185112953186035,
0.15066076815128326,
0.34338080883026123,
0.6849250197410583,
0.11611098796129227,
0.4451551139354706,
-0.5215367674827576,
0.06004016473889351,
-0.03779054805636406,
0.14650656282901764,
-0.2689078450202942,
-0.6242202520370483,
0.10987015068531036,
-0.2524588406085968,
0.31319206953048706,
-0.21085545420646667,
-0.04324393346905708,
0.013276035897433758,
0.38300177454948425,
-0.6082099080085754,
0.4438799023628235,
0.15397711098194122,
-0.21258953213691711,
-0.8903018236160278,
-0.009126155637204647,
-0.7046402096748352,
0.04726511985063553,
0.29082798957824707,
0.1954452246427536,
-0.31429269909858704,
-0.4329509139060974,
-0.11224222928285599,
0.06444664299488068,
0.25771626830101013,
-0.12013020366430283,
0.24583245813846588,
-0.5292196273803711,
-0.35706308484077454,
0.5627697706222534,
0.13036708533763885,
0.2717720568180084,
0.12623901665210724,
-0.1300043761730194,
-0.8164659738540649,
-0.688979983329773,
0.46348142623901367,
0.43247976899147034,
0.3238123655319214,
0.06373833119869232,
-0.7038004994392395,
0.19712458550930023,
-0.06123928353190422,
-0.43550434708595276,
0.3625599443912506,
0.46107083559036255,
-0.7988251447677612,
-0.5661424398422241,
-0.3893313407897949,
0.5755542516708374,
0.9235984086990356,
-0.28517815470695496,
-0.29800012707710266,
-0.19632582366466522,
0.15961724519729614,
0.1836872398853302,
-0.2735951542854309,
-0.11367633938789368,
-0.06430340558290482,
0.01062296237796545,
0.015963958576321602,
-0.29146629571914673,
0.38313594460487366,
0.3024638593196869,
0.03637233376502991,
0.21483029425144196,
0.8929464221000671,
-0.39201733469963074,
0.17020855844020844,
0.21273863315582275,
0.07568646222352982,
-0.24146360158920288,
0.16576825082302094,
-0.17299392819404602,
-0.6295360326766968,
0.001328552607446909,
-6.027744770050049,
0.07517801970243454,
-0.5028510093688965,
-0.2096748799085617,
-0.08861037343740463,
0.16150100529193878,
0.9804207682609558,
-0.3506123125553131,
0.3327246606349945,
-0.07393519580364227,
0.5000887513160706,
0.27932417392730713,
0.09893762320280075,
0.6055447459220886,
-0.003126592608168721,
0.49270662665367126,
0.591528594493866,
-0.07262637466192245,
0.4245246946811676,
-0.06095219776034355,
-0.1389211267232895,
-0.0756910890340805,
-0.25814035534858704,
0.7114365100860596,
0.6169403195381165,
0.43080809712409973,
-0.57863450050354,
-0.06214159354567528,
-0.1750522255897522,
-0.49043458700180054,
0.24140171706676483,
-0.12382794916629791,
0.3478413224220276,
-0.2918255627155304,
0.45546630024909973,
-0.06762242317199707,
0.14590449631214142,
0.4627334177494049,
0.04989532753825188,
-0.18854910135269165,
-0.011619056575000286,
0.4886524975299835,
0.044535208493471146,
0.16286775469779968,
0.35863253474235535,
0.1656767576932907,
-0.03839901089668274,
0.15092438459396362,
-0.41597166657447815,
0.7806363105773926,
0.2128113955259323,
-0.2340501993894577,
-0.17566551268100739,
0.3698168098926544,
-0.2723443806171417,
0.022535137832164764,
0.16684994101524353,
0.5476996302604675,
-0.1979464441537857,
0.47564247250556946,
-0.07822660356760025,
0.2196582555770874,
0.34690868854522705,
-0.605983555316925,
-0.4798738956451416,
0.08961810916662216,
-0.8796721696853638,
-0.5254866480827332,
0.07448432594537735,
-0.17613475024700165,
-0.5309718251228333,
-0.4114343822002411,
0.19661730527877808,
-0.8971343636512756,
-0.06153953820466995,
-0.5041494369506836,
-0.3235712945461273,
0.4332711696624756,
0.04790053889155388,
-0.34197402000427246,
-0.03377993032336235,
-0.10994048416614532,
0.45358335971832275,
0.05196778476238251,
0.017498981207609177,
-0.10828007012605667,
-0.13021522760391235,
0.14637146890163422,
-0.1120435819029808,
0.43715715408325195,
0.5098627209663391,
-0.6857276558876038,
0.24774937331676483,
0.08834943175315857,
-0.020600832998752594,
0.9538905620574951,
0.2344166338443756,
-0.2935104966163635,
-0.1724829375743866,
-0.5029739141464233,
0.8961147665977478,
-0.08032411336898804,
-0.7297645807266235,
-0.8147251605987549,
0.03593564033508301,
0.036970797926187515,
-0.3596721589565277,
0.24309292435646057,
0.4353797435760498,
-0.6093897819519043,
0.42773380875587463,
-0.09608802199363708,
-0.2612660229206085,
-0.6386092305183411,
0.6846693158149719,
-0.39665940403938293,
-0.062120769172906876,
0.1436721235513687,
-0.004099446348845959,
-0.2500167787075043,
0.15639029443264008,
0.38958823680877686,
0.08795187622308731,
0.18166358768939972,
0.25528979301452637,
-0.38140150904655457,
-0.22509044408798218,
0.21929733455181122,
-0.42219871282577515,
0.46556994318962097,
0.32775914669036865,
0.8351771831512451,
0.27643948793411255,
-0.37133142352104187,
0.11492326855659485,
-0.3945279121398926,
-0.5061950087547302,
0.26604288816452026,
0.385669469833374,
-0.35241201519966125,
0.16188427805900574,
-0.31973668932914734,
-0.045494161546230316,
0.3411005735397339,
0.3740038573741913,
-0.1392040103673935,
-0.733692467212677,
0.005121244583278894,
-0.3161182999610901,
-0.28950056433677673,
0.043336112052202225,
-0.019861552864313126,
0.3324781060218811,
-0.26680731773376465,
0.09386161714792252,
-0.376634806394577,
-0.05943898484110832,
0.3339323401451111,
-0.3461745083332062,
-0.7421556115150452,
0.515524685382843,
-0.5423866510391235,
-1.2689948081970215,
0.07571002095937729,
0.32094308733940125,
-0.454201340675354,
-0.21936501562595367,
-0.43876755237579346,
0.19193752110004425,
0.6385719776153564,
0.15856124460697174,
-0.41297677159309387,
-0.17551927268505096,
0.1975903958082199,
0.42928531765937805,
-0.4504459500312805,
-0.28427258133888245,
0.31086763739585876,
-0.08407560735940933,
-0.13620075583457947,
0.08801312744617462,
0.09421729296445847,
-0.42718347907066345,
0.42290642857551575,
0.9388192296028137,
0.4293069541454315,
0.03901328891515732,
-0.2344101071357727,
-0.19373562932014465,
-0.494710773229599,
0.596650242805481,
-0.11720389872789383,
0.2683303654193878,
0.12586243450641632,
-0.13966681063175201,
-0.4573724865913391,
0.23333097994327545,
0.39549437165260315,
-0.21454307436943054,
-0.011531246826052666,
0.04585789889097214,
0.34108567237854004,
-0.2568287253379822,
0.22490686178207397,
0.26782986521720886,
-0.36153551936149597,
0.13789726793766022,
0.08478643000125885,
-0.4862392544746399,
-0.2320404201745987,
-0.7770809531211853,
-0.3152143955230713,
-0.3731791079044342,
0.4293675124645233,
-0.5915728807449341,
0.00031931715784594417,
0.35055068135261536,
-0.6571263074874878,
-0.6365193724632263,
0.37198933959007263,
-0.1491491049528122,
-0.009980084374547005,
-0.6909775733947754,
-0.26744377613067627,
-0.25079697370529175,
-0.10085424035787582,
0.6635358929634094,
-0.8971766233444214,
0.41729965806007385,
-0.005594542250037193,
-0.13949716091156006,
-0.01987641677260399,
0.25286489725112915,
-0.19615642726421356,
-0.27942949533462524,
0.14501214027404785,
-0.059126462787389755,
-0.012673087418079376,
0.5719565749168396,
0.3895234763622284,
-0.13128285109996796,
0.5185035467147827,
0.1294594556093216,
-1.1979917287826538,
0.09459282457828522,
0.3246043622493744,
0.1726072132587433,
-0.6441665291786194,
-0.3770114481449127,
0.43771910667419434,
0.14382007718086243,
-0.5122004151344299,
0.4778524935245514,
-0.24570104479789734,
0.5582999587059021,
-0.3453567326068878,
-0.4837072193622589,
-0.35206732153892517,
0.19834621250629425,
0.380929172039032,
-0.26941654086112976,
-0.5922682285308838,
0.12819063663482666,
-0.025606652721762657,
0.2814010679721832,
-0.04877056926488876,
0.03046669252216816,
-0.2650407552719116,
0.20703719556331635,
-0.38505348563194275,
-0.004499063827097416,
-0.22928255796432495,
0.6348204612731934,
-0.039421942085027695,
0.1551145762205124,
-0.02026337757706642,
-0.44960951805114746,
-0.11427139490842819,
-0.19688531756401062,
0.42747461795806885,
-0.6770544648170471,
-0.5068100690841675,
-0.04891714081168175,
-0.5565707683563232,
0.20519091188907623,
-0.2080373764038086,
0.2951779365539551,
0.19692738354206085,
-0.24835269153118134,
-0.2433580756187439,
0.04297551140189171,
-0.31668147444725037,
-0.43658366799354553,
-0.10508447885513306,
-0.2353346049785614,
0.2634359896183014,
0.17391106486320496,
0.18337158858776093,
0.12125711888074875,
-0.4653767943382263,
-0.07300003618001938,
0.5615254044532776,
-0.07258422672748566,
-0.17035114765167236,
0.21829797327518463,
0.040694937109947205,
-0.02437031827867031,
0.024834685027599335,
-0.1913088858127594,
0.34485507011413574,
0.40937718749046326,
0.28371840715408325,
0.3751266598701477,
0.7081806659698486,
-0.30482617020606995,
-0.0407143272459507,
-0.01853318139910698,
-0.2200678139925003,
0.5590161085128784,
0.25501513481140137,
0.2715875804424286,
0.14701814949512482,
0.3437425494194031,
0.2454724907875061,
0.10715916752815247,
0.5894531607627869,
0.19581036269664764,
0.2753859758377075,
0.2443244904279709,
0.15178677439689636,
0.22942231595516205,
0.693670392036438,
-0.40272223949432373,
0.460690438747406,
-0.13604828715324402,
0.5503750443458557,
0.40194419026374817,
-0.6733655333518982,
-0.2477995902299881,
-0.035746365785598755,
0.9077876210212708,
0.17474888265132904,
0.1687004119157791,
-0.43767309188842773,
0.4966799020767212,
0.1550440788269043,
-0.022655241191387177,
-0.4574746787548065,
0.08462513983249664,
0.23286795616149902,
0.3208458423614502,
-0.37405627965927124,
-0.31146571040153503,
-0.288710355758667,
-0.3483535945415497,
0.19337914884090424,
-0.47290727496147156,
-0.3762652277946472,
-0.8429266214370728,
0.07371338456869125,
0.2574724853038788,
-0.1403498649597168,
-0.3278365135192871,
0.3138613700866699,
-0.2289087176322937,
-0.3720795810222626,
0.29679393768310547,
0.49210357666015625,
-0.17839449644088745,
-0.3711244463920593,
-0.14789578318595886,
-0.40094301104545593,
-0.05819191038608551,
-0.21768973767757416,
0.1187044084072113,
-0.3985428214073181,
0.3378241956233978,
-0.05908918008208275,
-0.008063919842243195,
0.5523247122764587,
-0.015049753710627556,
0.5803408622741699,
-0.2604391276836395,
-0.4081561267375946,
-0.29256394505500793,
-0.24643096327781677,
-0.2545052170753479,
0.19927190244197845,
-0.05540366470813751,
-0.031487125903367996,
0.09783187508583069,
-0.17997059226036072,
-0.2109619528055191,
0.5935474634170532,
-0.10941558331251144,
-0.4596002995967865,
-0.18082165718078613,
0.7509876489639282,
0.5431619882583618,
-0.22681918740272522,
-0.24817371368408203,
-0.47552284598350525,
-0.07667757570743561,
0.615435779094696,
-0.3794011175632477,
0.4148614704608917,
-0.5939830541610718,
-0.19830985367298126,
-0.3195403814315796,
0.1772388219833374,
0.45755866169929504,
0.44092416763305664,
-0.4410380721092224,
-0.10956734418869019,
0.13280931115150452,
0.15828706324100494,
0.8191831111907959,
-0.40830138325691223,
-0.395614892244339,
-0.498457133769989,
-0.19248053431510925,
-0.643459677696228,
0.7754381895065308,
-0.3173358142375946,
0.2866310477256775,
-0.09693989902734756,
-0.009798098355531693,
0.48558664321899414,
-0.0038174965884536505,
0.4800322949886322,
-0.7427846789360046,
-0.4365023672580719,
-0.48791491985321045,
0.39222878217697144,
-0.3593095541000366,
0.7113754749298096,
0.2238180786371231,
0.025635482743382454,
0.4064009487628937,
-0.4945743680000305,
-0.09370645880699158,
-0.5204007625579834,
0.4028244912624359,
0.07697668671607971,
0.2543933391571045,
0.6009301543235779,
0.245666041970253,
-0.19616077840328217,
-0.20568311214447021,
0.13867104053497314,
-0.14411073923110962,
-1.0238481760025024,
0.3192276656627655,
0.17246316373348236,
0.1521165817975998,
-0.29920080304145813,
-0.057858116924762726,
-0.35138508677482605,
0.03706704452633858,
-0.6985157132148743
] |
Caudal-related homeobox transcription factor 2 (CDX2), an intestine-specific nuclear transcription factor, has been strongly implicated in the tumourigenesis of various human cancers. However, the functional role of CDX2 in the development and progression of colorectal cancer (CRC) is not well known. In this study, CDX2 knockdown in colon cancer cells promoted cell proliferation in vitro, accelerated tumor formation in vivo, and induced a cell cycle transition from G0/G1 to S phase, whereas CDX2 overexpression inhibited cell proliferation. TOP/FOP-Flash reporter assay showed that CDX2 knockdown or CDX2 overexpression significantly increased or decreased Wnt signaling activity. Western blot assay showed that downstream targets of Wnt signaling, including β-catenin, cyclin D1 and c-myc, were up-regulated or down-regulated in CDX2-knockdown or CDX2-overexpressing colon cancer cells. In addition, suppression of Wnt signaling by XAV-939 led to a marked suppression of the cell proliferation enhanced by CDX2 knockdown, whereas activation of this signaling by CHIR-99021 significantly enhanced the cell proliferation inhibited by CDX2 overexpression. Dual-luciferase reporter and quantitative chromatin immunoprecipitation (qChIP) assays further confirmed that CDX2 transcriptionally activates glycogen synthase kinase-3β (GSK-3β) and axis inhibition protein 2 (Axin2) expression by directly binding to the promoter of GSK-3β and the upstream enhancer of Axin2. In conclusion, these results indicated that CDX2 inhibits the proliferation and tumor formation of colon cancer cells by suppressing Wnt/β-catenin signaling. | [
-0.001867522718384862,
0.007697442080825567,
-0.02706877328455448,
0.01515306904911995,
-0.01897796243429184,
-0.020343057811260223,
0.012678871862590313,
-0.005452169571071863,
-0.0114448182284832,
-0.0070096817798912525,
-0.011068474501371384,
-0.003631995525211096,
0.002909138100221753,
0.025670085102319717,
-0.03026420623064041,
-0.00838444847613573,
-0.004081738647073507,
0.012324094772338867,
0.018682274967432022,
0.00478794239461422,
0.030021578073501587,
-0.015746090561151505,
0.010330133140087128,
0.022187961265444756,
-0.0003608493134379387,
-0.0020475415512919426,
0.018870580941438675,
0.0166483074426651,
-0.0017106248997151852,
0.022400066256523132,
-0.02027471736073494,
-0.024014832451939583,
0.029289554804563522,
0.012693566270172596,
0.0020849783904850483,
-0.019501907750964165,
-0.0062216296792030334,
0.02412359043955803,
-0.008943704888224602,
-0.006274440325796604,
-0.0006866483017802238,
-0.016031518578529358,
0.002205323427915573,
0.025513065978884697,
-0.008387751877307892,
-0.0025408389046788216,
-0.0005011312896385789,
0.012399897910654545,
0.01702694408595562,
0.00771127687767148,
-0.00800128560513258,
-0.005498954094946384,
-0.008899572305381298,
0.014775820076465607,
-0.0061032590456306934,
0.01347813569009304,
0.016865819692611694,
0.01196695864200592,
-0.01270858570933342,
0.020148348063230515,
0.016090035438537598,
-0.008321407251060009,
0.002519420348107815,
-0.05411780625581741,
0.010218530893325806,
-0.0668986514210701,
-0.007984778843820095,
0.008700120262801647,
0.0016095348400995135,
0.0034108650870621204,
-0.015325764194130898,
0.01122488547116518,
0.014119857922196388,
-0.025548603385686874,
-0.03798072040081024,
-0.00940396822988987,
-0.00576676893979311,
-0.010593353770673275,
0.006992684677243233,
0.0017867987044155598,
-0.017994310706853867,
-0.011369024403393269,
-0.009019128046929836,
0.014341490343213081,
0.016934506595134735,
0.0063499272800982,
-0.0037823135498911142,
-0.006108936853706837,
-0.004083939362317324,
0.0021955622360110283,
0.01677182875573635,
-0.005000818986445665,
0.016464993357658386,
0.016493910923600197,
-0.019984392449259758,
-0.02604091726243496,
0.003900957992300391,
-0.027924608439207077,
0.03506936877965927,
-0.0014451835304498672,
-0.013810364529490471,
-0.00020143925212323666,
0.011776803992688656,
0.003814179450273514,
-0.0456271767616272,
0.009423553943634033,
-0.014702294021844864,
-0.008485405705869198,
-0.0016441899351775646,
0.01384040154516697,
-0.014341482892632484,
0.017512047663331032,
0.022255998104810715,
-0.004912190139293671,
0.025297973304986954,
0.005063504911959171,
-0.027271486818790436,
-0.007544953376054764,
0.01285812258720398,
0.01863027922809124,
0.009600712917745113,
-0.005812759045511484,
-0.0007524748798459768,
0.007250543218106031,
0.0013814064441248775,
-0.0035858750343322754,
-0.020970426499843597,
0.004105387255549431,
0.004766201134771109,
-0.000872365664690733,
-0.008639500476419926,
0.005914437584578991,
0.0192280113697052,
-0.014272013679146767,
-0.022281654179096222,
-0.006282350979745388,
-0.032298777252435684,
-0.0005631274543702602,
-0.00959254615008831,
-0.006233557127416134,
-0.013971581123769283,
0.0029782638885080814,
0.005526363849639893,
0.006536155007779598,
0.013419831171631813,
0.011798009276390076,
-0.025439169257879257,
0.0013002816122025251,
-0.01218181848526001,
-0.0028650565072894096,
-0.004659706261008978,
0.0026910090819001198,
-0.00336473248898983,
-0.01138070598244667,
0.018889736384153366,
-0.01785373128950596,
-0.02597067505121231,
-0.018632013350725174,
0.001392602687701583,
0.0077940430492162704,
-0.023392993956804276,
-0.012762502767145634,
0.03211008012294769,
0.009588824585080147,
0.021460670977830887,
-0.006448895670473576,
-0.009703932330012321,
0.011230600997805595,
0.008812805637717247,
0.00800972618162632,
-0.009812328964471817,
0.001623391406610608,
-0.0038745244964957237,
0.010477615520358086,
-0.02108355052769184,
0.0011391001753509045,
-0.0002022869884967804,
0.007311827037483454,
-0.004644180182367563,
0.06705183535814285,
-0.022163886576890945,
0.006088546477258205,
-0.009907949715852737,
0.0029998035170137882,
0.008375993929803371,
-0.019511111080646515,
0.006428035907447338,
-0.005761407315731049,
0.007134206593036652,
-0.03137001395225525,
-0.001220416510477662,
-0.00393005320802331,
-0.03198382258415222,
0.0024630012921988964,
0.006241271272301674,
0.003900269279256463,
-0.02608291618525982,
0.012877289205789566,
0.033261269330978394,
0.02670515887439251,
-0.030972931534051895,
-0.015743296593427658,
0.03296493738889694,
-0.02926766872406006,
-0.006232323590666056,
-0.0034732352942228317,
0.00552118755877018,
-0.03508066385984421,
0.018135353922843933,
-0.029028814285993576,
-0.008901987224817276,
0.005802829749882221,
0.00894258078187704,
-0.009472314268350601,
0.008906329050660133,
0.005301587283611298,
-0.009009154513478279,
0.034004271030426025,
-0.015118055045604706,
-0.013656632974743843,
0.000457444810308516,
0.012622675858438015,
0.01373143307864666,
-0.03792450204491615,
0.03728296980261803,
0.001948646386153996,
-0.009253999218344688,
0.009882309474050999,
0.024263670668005943,
0.00804908573627472,
0.0013752187369391322,
-0.024704935029149055,
-0.013189204037189484,
0.010098867118358612,
0.003972277976572514,
-0.006649425253272057,
0.01364118978381157,
-0.0332176648080349,
0.013493082486093044,
-0.014618495479226112,
-0.027470149099826813,
-0.016594339162111282,
0.0272095687687397,
-0.010233407840132713,
0.011628272943198681,
-0.02348676323890686,
0.03209477663040161,
0.003853566013276577,
0.02917317859828472,
-0.019056858494877815,
0.008988184854388237,
-0.023846402764320374,
0.00435303058475256,
0.015432125888764858,
0.010680084116756916,
-0.016493266448378563,
-0.021163569763302803,
0.013356193900108337,
0.024677101522684097,
-0.010281361639499664,
-0.003940051421523094,
0.007851638831198215,
0.023608947172760963,
-0.001875788439065218,
0.016543949022889137,
-0.004909393843263388,
0.024238649755716324,
0.03157114237546921,
0.036073364317417145,
0.00566942198202014,
0.011561119928956032,
-0.0021226354874670506,
-0.0031833332031965256,
-0.08186329901218414,
-0.013010799884796143,
-0.022752759978175163,
0.025492776185274124,
0.009830941446125507,
-0.01064382866024971,
-0.007765746675431728,
0.006948827300220728,
0.0029179821722209454,
-0.010133126750588417,
0.026542074978351593,
0.006626514717936516,
-0.01218590047210455,
-0.002485864795744419,
-0.024111460894346237,
-0.018256351351737976,
0.01908520609140396,
-0.0186836626380682,
-0.008669623173773289,
-0.0031710152979940176,
0.011352954432368279,
0.01127626933157444,
0.012254627421498299,
-0.009111871011555195,
0.009607819840312004,
0.013810701668262482,
0.0057502370327711105,
0.004800138063728809,
-0.004290331620723009,
0.005667792167514563,
0.0038687027990818024,
-0.011256369762122631,
0.023751532658934593,
0.0073049478232860565,
0.007160575594753027,
-0.009888680651783943,
0.0031580172944813967,
0.0036460570991039276,
-0.01774270460009575,
0.05030643194913864,
-0.02998333051800728,
0.014786520041525364,
0.00914381816983223,
0.013750998303294182,
-0.007026744075119495,
0.0029054926708340645,
-0.010827134363353252,
0.009615005925297737,
0.020689215511083603,
-0.00006770342588424683,
-0.0059350295923650265,
0.0024506808258593082,
-0.002124822698533535,
0.016073083505034447,
-0.020631350576877594,
-0.015379073098301888,
-0.0016693973448127508,
-0.02601323276758194,
-0.014728261157870293,
-0.01158164069056511,
0.039674997329711914,
-0.004452689550817013,
0.037565648555755615,
-0.01770763099193573,
0.0036466545425355434,
0.0012519701849669218,
0.02422824501991272,
0.00206169206649065,
-0.04680879786610603,
0.006232462357729673,
0.0034735738299787045,
-0.021900005638599396,
0.003933286294341087,
-0.008570769801735878,
-0.0073478370904922485,
-0.012354215607047081,
-0.011293148621916771,
-0.0017439229413866997,
0.016015488654375076,
-0.03553503751754761,
-0.013995293527841568,
-0.002280564047396183,
-0.00621724221855402,
0.006355130113661289,
-0.00558716943487525,
-0.012758715078234673,
0.009283246472477913,
0.03044666349887848,
0.006738330703228712,
-0.02006828598678112,
0.027765825390815735,
0.02840958535671234,
-0.016397472470998764,
0.01405705139040947,
0.008793845772743225,
-0.008672978729009628,
0.005468935705721378,
-0.0022987278643995523,
0.034798502922058105,
0.009518531151115894,
-0.03550485521554947,
-0.0018644125666469336,
0.006535817869007587,
-0.01190987229347229,
-0.02109316550195217,
0.012045154348015785,
0.006949621252715588,
-0.009919915348291397,
0.002351919189095497,
0.0002750242128968239,
-0.019221313297748566,
-0.0026196972467005253,
-0.01357005350291729,
0.04355737566947937,
0.008114144206047058,
0.011960238218307495,
0.00501665286719799,
-0.014165053144097328,
0.0717959851026535,
-0.0015891175717115402,
0.011429494246840477,
-0.011243555694818497,
-0.004551089368760586,
-0.017470143735408783,
-0.02335280552506447,
-0.010402726009488106,
-0.008937873877584934,
-0.004625717177987099,
0.012702413834631443,
0.01480421144515276,
0.014815600588917732,
0.0119241401553154,
-0.00690099410712719,
0.018031209707260132,
0.01515007484704256,
0.0007391590625047684,
0.021052345633506775,
-0.008662108331918716,
0.0011748317629098892,
-0.005882435943931341,
-0.004584664478898048,
0.000826733186841011,
0.018941501155495644,
-0.019496111199259758,
0.03300861269235611,
-0.014304486103355885,
-0.02287242002785206,
0.012744180858135223,
0.03719191998243332,
-0.024685882031917572,
-0.008205631747841835,
0.017395254224538803,
0.01891561597585678,
-0.00378623278811574,
0.02593318000435829,
-0.005973192863166332,
0.013451716862618923,
0.011365517973899841,
0.003065231256186962,
-0.020466584712266922,
0.010562632232904434,
-0.000041141174733638763,
-0.011819006875157356,
-0.020544715225696564,
0.037804268300533295,
-0.006569831632077694,
0.003459824714809656,
0.005431187804788351,
-0.005840941797941923,
-0.0048006437718868256,
0.009730234742164612,
0.0032183811999857426,
-0.00877363607287407,
-0.025120597332715988,
0.0018909773789346218,
-0.0023803727235645056,
0.014574934728443623,
0.0032757362350821495,
0.002808213233947754,
0.00004846462979912758,
0.015058398246765137,
-0.017028933390975,
-0.009092732332646847,
-0.0020864896941930056,
-0.006567140109837055,
0.0016119895735755563,
-0.0047087776474654675,
-0.02107713185250759,
0.004133948590606451,
-0.008833851665258408,
-0.02550080418586731,
-0.026652811095118523,
0.007491066120564938,
-0.0013056346215307713,
0.01165024284273386,
-0.005101979710161686,
0.0025001747999340296,
-0.031586844474077225,
-0.050385575741529465,
-0.01018713042140007,
0.015837140381336212,
0.01807764172554016,
0.004685820080339909,
-0.006330293137580156,
-0.01958317868411541,
-0.07440076023340225,
-0.03622189909219742,
-0.011853723786771297,
-0.006513940170407295,
0.0063339597545564175,
-0.01986003667116165,
-0.017665941268205643,
-0.03434053063392639,
-0.023621926084160805,
0.00426669605076313,
-0.03335972875356674,
-0.009657973423600197,
0.00015802448615431786,
-0.0029704126063734293,
0.012408831156790257,
0.0011928682215511799,
0.001958566950634122,
0.002172352746129036,
-0.024459701031446457,
0.000634247437119484,
0.005155663937330246,
0.020395668223500252,
0.012276827357709408,
-0.017537906765937805,
0.0015386502491310239,
-0.08081172406673431,
-0.011035677045583725,
0.009969379752874374,
-0.016446702182292938,
0.004333128221333027,
-0.041006892919540405,
0.015402061864733696,
-0.02319975756108761,
0.00599390035495162,
-0.01668543368577957,
-0.026415515691041946,
0.010427655652165413,
-0.022560574114322662,
0.014863910153508186,
0.009362973272800446,
-0.0077573321759700775,
0.018143657594919205,
-0.014072233811020851,
-0.005733012221753597,
-0.009086201898753643,
-0.004267078824341297,
0.0050912960432469845,
-0.010123070329427719,
-0.005745244212448597,
-0.011105204001069069,
-0.01824232190847397,
-0.0053578829392790794,
0.016717422753572464,
-0.0073466673493385315,
0.005011662375181913,
0.007769751828163862,
0.000356307253241539,
-0.016821475699543953,
-0.012308165431022644,
-0.0024239281192421913,
-0.01681719534099102,
-0.02257142774760723,
-0.010980706661939621,
-0.015366549603641033,
-0.0005936385132372379,
0.00283966981805861,
0.0018379853572696447,
0.00941961258649826,
0.0058599961921572685,
-0.0011383637320250273,
0.0007237307727336884,
0.007011516485363245,
-0.009841350838541985,
0.0036538890562951565,
-0.018842514604330063,
0.013658121228218079,
-0.016267208382487297,
-0.030668411403894424,
0.024547191336750984,
-0.003561692778021097,
0.006931749172508717,
-0.004595288075506687,
-0.012500498443841934,
0.0009851236827671528,
0.009047085419297218,
0.006985723506659269,
0.009405222721397877,
-0.0004858812317252159,
0.07214266061782837,
0.0015523785259574652,
0.013843072578310966,
-0.025850562378764153,
-0.004587559029459953,
0.007166406139731407,
-0.002402027603238821,
0.023823093622922897,
-0.01841980591416359,
-0.016063081100583076,
-0.014409410767257214,
-0.012241018936038017,
0.018053686246275902,
0.015576854348182678,
0.009587124921381474,
-0.032200731337070465,
0.015462886542081833,
-0.00026254821568727493,
0.012094361707568169,
0.05163805931806564,
0.008678242564201355,
0.00021405122242867947,
0.017268873751163483,
-0.010055404156446457,
0.002008113544434309,
-0.004845095798373222,
0.003754578996449709,
-0.01206286158412695,
0.009718097746372223,
0.00503129605203867,
-0.002293454483151436,
-0.0013512251898646355,
-0.0016513073351234198,
-0.009583830833435059,
0.016818413510918617,
-0.003847321029752493,
-0.008025795221328735,
0.013522024266421795,
-0.021497119218111038,
-0.007474102079868317,
0.026790786534547806,
-0.012525702826678753,
-0.003906962927430868,
-0.0002450481988489628,
0.011373929679393768,
-0.03571827709674835,
-0.002179369330406189,
-0.022163379937410355,
-0.013133447617292404,
0.011246475391089916,
0.026547614485025406,
-0.0012518458534032106,
-0.030376503244042397,
0.014864758588373661,
0.008036368526518345,
-0.015204447321593761,
-0.019115205854177475,
0.018777796998620033,
-0.02036333829164505,
-0.01362275704741478,
0.017043597996234894,
-0.02382565289735794,
-0.014549016021192074,
-0.01378406397998333,
0.02045529894530773,
-0.029822563752532005,
0.02754775993525982,
-0.023681044578552246,
0.0024661393836140633,
0.016140101477503777,
0.00952931959182024,
0.017071111127734184,
0.012541519477963448,
0.005534905940294266,
0.023617424070835114,
0.021914619952440262,
-0.014454768970608711,
-0.009335145354270935,
0.03236745297908783,
0.023012777790427208,
-0.013962820172309875,
0.036369889974594116,
-0.03914014622569084,
-0.021818844601511955,
-0.0029805167578160763,
0.008562863804399967,
0.0015917401760816574,
-0.006475243717432022,
-0.0018084838520735502,
0.014671140350401402,
0.028742065653204918,
0.003523527877405286,
-0.0021420372650027275,
0.013106752187013626,
0.008856520056724548,
0.034276459366083145,
0.02804017812013626,
-0.00017379247583448887,
0.002316097030416131,
-0.002036049496382475,
0.013602383434772491,
0.017748262733221054,
-0.01910243183374405,
-0.003845376893877983,
-0.037629835307598114,
-0.014233886264264584,
-0.010841669514775276,
-0.009344297461211681,
-0.004197226837277412,
0.033075518906116486,
0.015803471207618713,
-0.04337494820356369,
0.0232975073158741,
0.02541692927479744,
0.02628660574555397,
0.03648023307323456,
-0.0049329716712236404,
-0.0014021582901477814,
-0.013691108673810959,
-0.01735721528530121,
-0.011684355325996876,
-0.006123670376837254,
-0.01007408183068037,
0.030119404196739197,
-0.030169015750288963,
0.004683337174355984,
-0.00973690114915371,
0.026088008657097816,
0.01715407334268093,
-0.03615524619817734,
0.01035141572356224,
-0.005798592232167721,
-0.0009478246793150902,
0.009423824027180672,
-0.003911511041224003,
-0.004934690892696381,
-0.002768194302916527,
0.03879436105489731,
-0.012713195756077766,
0.026653937995433807,
-0.0028251411858946085,
-0.015841590240597725,
-0.010101571679115295,
0.00832176860421896,
0.006782948970794678,
-0.010220857337117195,
-0.013076082803308964,
0.0014304190408438444,
-0.0013198426458984613,
-0.015803126618266106,
0.02066102623939514,
0.020623650401830673,
-0.0061782849952578545,
-0.007912366650998592,
-0.00015065260231494904,
0.016103148460388184,
0.005173725076019764,
0.004492919892072678,
-0.0008892793557606637,
-0.0017227549105882645,
-0.000014588236808776855,
-0.028442978858947754,
-0.016796031966805458,
0.015329379588365555,
0.037185873836278915,
0.009259305894374847,
-0.022278964519500732,
0.00782842468470335,
-0.0016364282928407192,
-0.03676255792379379,
0.01876964047551155,
0.027859024703502655,
0.009471327066421509,
0.018985889852046967,
-0.02633889578282833,
-0.0019979742355644703,
-0.009651071391999722,
-0.003039829432964325,
-0.017915591597557068,
0.0022043734788894653,
0.007456693798303604,
-0.04191629961133003,
0.009532514959573746,
-0.010840143077075481,
-0.00963224284350872,
0.00611219834536314,
-0.007175468374043703,
-0.008158526383340359,
-0.01841697469353676,
-0.026596710085868835,
-0.012338431552052498,
0.019946986809372902,
-0.0016296666581183672,
0.014211408793926239,
-0.0032165339216589928,
-0.015209010802209377,
0.012362722307443619,
0.00586320273578167,
0.018737677484750748,
-0.007920674979686737,
0.013370578177273273,
-0.02326996624469757
] | [
-0.14783774316310883,
0.2040947526693344,
-0.016400402411818504,
-0.022696102038025856,
-0.24649347364902496,
-0.27409374713897705,
-0.07019896060228348,
0.13124705851078033,
-0.05317060649394989,
-0.41288772225379944,
-0.12630175054073334,
-0.04313276708126068,
-0.2662172019481659,
0.4950690269470215,
-0.08483263850212097,
0.9027833938598633,
0.30309927463531494,
0.3983663022518158,
-0.3865768313407898,
-0.6399199366569519,
-0.3827510476112366,
-0.47788557410240173,
0.01670599915087223,
0.29537686705589294,
-0.018156418576836586,
0.14645454287528992,
0.17772378027439117,
0.3324038088321686,
0.4691617786884308,
-0.25881558656692505,
-0.01656275987625122,
0.2630089819431305,
0.4592268466949463,
-0.29800868034362793,
-0.23580783605575562,
-0.41537782549858093,
-0.22063474357128143,
-0.12556226551532745,
-0.18885040283203125,
-0.22558528184890747,
-0.5112261176109314,
-0.13234806060791016,
0.27603042125701904,
0.15091492235660553,
-0.454422265291214,
0.20001399517059326,
-0.6207981109619141,
0.9742287993431091,
-0.10780519992113113,
-0.0056334990076720715,
0.21076272428035736,
0.13116560876369476,
-0.2992746829986572,
0.028139429166913033,
0.2861200273036957,
0.10795483738183975,
-0.40212181210517883,
0.10252577066421509,
0.18014594912528992,
-0.9834902286529541,
0.256966233253479,
0.10444097220897675,
-0.159147247672081,
0.1019822433590889,
-0.021796349436044693,
0.6785677075386047,
-0.41765716671943665,
-0.008324039168655872,
-0.9362459778785706,
-0.36357438564300537,
0.2779041528701782,
-0.2892591953277588,
0.14975637197494507,
0.5728228688240051,
0.03547731414437294,
-0.018260877579450607,
-0.7900306582450867,
-0.23713237047195435,
0.40695470571517944,
-0.539605975151062,
0.21493807435035706,
-0.05964234471321106,
0.3554515242576599,
-0.01323668658733368,
0.09902016818523407,
0.2564205825328827,
0.07449044287204742,
0.076500304043293,
-0.4892837107181549,
-0.014816186390817165,
-0.6377621293067932,
0.33808502554893494,
0.5845950841903687,
0.11554770916700363,
0.07737455517053604,
0.425555944442749,
0.2670770287513733,
-0.04674537107348442,
0.33683767914772034,
-0.012931672856211662,
-0.6912350058555603,
-0.11383400112390518,
0.2826854884624481,
-0.11847326904535294,
-0.823915958404541,
-0.2501491606235504,
-0.07796928286552429,
-0.0390605553984642,
-0.7030795812606812,
0.26925018429756165,
-0.8175171613693237,
-0.22212646901607513,
-0.2645493745803833,
-0.21588627994060516,
0.05098393186926842,
0.08188610523939133,
-0.38679641485214233,
-0.3219459652900696,
0.2887543737888336,
-0.41313689947128296,
-0.6401200890541077,
0.7906980514526367,
-0.4296363592147827,
0.5639752745628357,
0.1344788819551468,
-0.014751307666301727,
0.03635583072900772,
-0.21064692735671997,
-0.16139313578605652,
0.2893901765346527,
0.4866238534450531,
0.37216752767562866,
-0.33349815011024475,
0.3480275273323059,
-0.06971582770347595,
-0.1894570142030716,
0.22440136969089508,
0.17837075889110565,
0.12157410383224487,
-0.021037127822637558,
-0.6693348288536072,
-0.44451937079429626,
-0.2001858800649643,
0.04279563948512077,
-0.08117745071649551,
-0.16688945889472961,
-0.027257533743977547,
-0.036710191518068314,
-0.13600218296051025,
-0.4640563428401947,
0.12690696120262146,
-0.21205946803092957,
-0.3918757438659668,
-0.46614786982536316,
0.26409292221069336,
0.7047758102416992,
0.14253540337085724,
-0.3918127715587616,
0.3556746542453766,
0.4546183943748474,
0.4580773711204529,
-0.05748767405748367,
-0.3492821156978607,
0.24329853057861328,
0.93153315782547,
-0.1949722170829773,
0.2524339556694031,
0.15703469514846802,
-0.6547550559043884,
0.15259972214698792,
-0.4743388295173645,
-0.301211953163147,
0.032948482781648636,
-0.2548513412475586,
0.12663348019123077,
-0.09008700400590897,
-0.01653999462723732,
-0.304362416267395,
-0.18703535199165344,
-0.09680396318435669,
-0.6892871260643005,
-0.03871706873178482,
-0.38866862654685974,
-0.04382763057947159,
0.16908201575279236,
-0.053333841264247894,
0.5529215335845947,
-0.41381654143333435,
0.21966931223869324,
-0.05475373938679695,
-0.18916164338588715,
-0.30884653329849243,
0.38443759083747864,
-0.18444454669952393,
1.554913878440857,
-0.2502261996269226,
-0.27899542450904846,
0.9780263304710388,
0.06270655989646912,
0.26738283038139343,
-0.4316871464252472,
-0.10370903462171555,
0.9679858088493347,
-0.09063014388084412,
-0.11165523529052734,
0.16105873882770538,
-0.08423610776662827,
0.23683598637580872,
0.14040303230285645,
0.11909700930118561,
-0.10246267169713974,
-0.287038654088974,
-0.3387618660926819,
0.19721098244190216,
0.48774901032447815,
-0.48149579763412476,
0.07202765345573425,
-0.18402759730815887,
-0.20982769131660461,
-0.4895455539226532,
0.057193901389837265,
-0.46082890033721924,
0.252422571182251,
1.0754200220108032,
-0.15229706466197968,
0.8336706161499023,
0.5205471515655518,
0.6107258796691895,
0.5007340312004089,
-0.010901269502937794,
0.12799891829490662,
-0.10661718994379044,
0.20916394889354706,
-0.1261250525712967,
0.3472985327243805,
0.1369733065366745,
0.06484242528676987,
-0.3478773236274719,
-0.11430612206459045,
-0.11129841953516006,
0.09108304232358932,
-0.09697665274143219,
-0.2640685737133026,
-0.1320360153913498,
0.2631298899650574,
-0.6588043570518494,
-0.07377156615257263,
0.6415212154388428,
-0.8232083320617676,
0.019635729491710663,
-0.06681393831968307,
0.3482213616371155,
0.26219499111175537,
-0.42312586307525635,
0.054820429533720016,
0.4051801264286041,
0.09119710326194763,
-0.21893475949764252,
-0.0363299660384655,
-0.616603672504425,
-0.1419307142496109,
0.03126370161771774,
0.17118299007415771,
-0.0173359178006649,
0.17534367740154266,
0.2389747053384781,
-0.6086142659187317,
-0.13767953217029572,
1.031136155128479,
0.4264022409915924,
0.3021014332771301,
-0.06464764475822449,
-0.6681537628173828,
-0.382985383272171,
-0.3959124982357025,
-0.6746867299079895,
-0.04515894129872322,
0.07857539504766464,
-0.24998822808265686,
-0.5495810508728027,
-0.33371850848197937,
-0.27154865860939026,
0.6254996061325073,
-0.21431569755077362,
-0.3987976312637329,
0.038730934262275696,
-0.21437649428844452,
-0.42614853382110596,
-0.7552721500396729,
-0.39417117834091187,
0.2668682634830475,
0.11015395075082779,
-0.34758567810058594,
0.15213261544704437,
0.10635591298341751,
-0.14714032411575317,
-0.0610186830163002,
-0.03198883309960365,
0.6876495480537415,
-0.3594914972782135,
-0.1773989051580429,
0.03443225100636482,
0.0418475903570652,
0.16120848059654236,
0.3343401849269867,
-0.15988245606422424,
-0.14684869349002838,
0.29562094807624817,
-6.1057891845703125,
-0.0555548258125782,
-0.3054216504096985,
-0.3004513382911682,
-0.004118002485483885,
-0.009893269278109074,
0.8646112680435181,
-0.17636249959468842,
0.2542981505393982,
0.08543527871370316,
0.10474804788827896,
0.422882080078125,
-0.3308640420436859,
0.006863096728920937,
-0.09795567393302917,
0.1466948688030243,
-0.1904822736978531,
-0.06602024286985397,
0.16134075820446014,
0.051744475960731506,
0.25315621495246887,
-0.008496821857988834,
0.015890372917056084,
0.16324831545352936,
-0.15800179541110992,
0.33741873502731323,
-0.9488703012466431,
0.20968611538410187,
-0.19760629534721375,
-0.5652029514312744,
0.04154716804623604,
0.0336000956594944,
-0.05143953487277031,
0.11717774718999863,
0.23849372565746307,
-0.2137977033853531,
0.18380792438983917,
0.2741294503211975,
-0.16705983877182007,
-0.1834442913532257,
0.5339115858078003,
0.012727521359920502,
-0.14348356425762177,
0.13317306339740753,
0.33637192845344543,
-0.12125711888074875,
-0.06279777735471725,
0.35365790128707886,
-0.5049721598625183,
0.7408127784729004,
-0.024292191490530968,
0.0709758996963501,
0.15761558711528778,
0.970940351486206,
0.32679906487464905,
0.1204923465847969,
-0.2756013870239258,
-0.3971308171749115,
-0.3878163695335388,
0.08723235130310059,
-0.3885420858860016,
-0.301582396030426,
-0.07314269989728928,
-0.800537645816803,
0.30471107363700867,
0.425981342792511,
-0.6295227408409119,
-0.25722581148147583,
0.17166683077812195,
0.09875953942537308,
-0.1314796507358551,
0.09298471361398697,
0.4620210826396942,
-0.7215692400932312,
0.6650102138519287,
-0.8668941259384155,
0.13401953876018524,
-0.08162016421556473,
-0.04789131507277489,
0.31868594884872437,
0.2452743947505951,
-0.05088379606604576,
-0.39130717515945435,
0.06362247467041016,
0.037861187011003494,
-0.29334521293640137,
-0.05497902259230614,
0.14119262993335724,
0.16283367574214935,
0.4541798233985901,
0.34987911581993103,
0.015407264232635498,
-0.0008274235296994448,
0.321499228477478,
0.0562194287776947,
0.45256784558296204,
-0.13410314917564392,
0.6795337200164795,
0.4924430251121521,
-0.012173915281891823,
0.809148907661438,
0.09216074645519257,
-0.664180338382721,
-0.31537848711013794,
-0.243673637509346,
-0.07189053297042847,
0.00002933988071163185,
0.2875816226005554,
0.45853033661842346,
-0.7445804476737976,
0.11219790577888489,
-0.3066950738430023,
-0.4204256534576416,
-0.33686891198158264,
0.8025181889533997,
-0.12812106311321259,
-0.17527832090854645,
0.29774755239486694,
0.3906197249889374,
-0.17525504529476166,
0.1773381382226944,
0.3946491777896881,
-0.7314727306365967,
0.45825275778770447,
-0.07781949639320374,
0.09104324132204056,
0.020530566573143005,
0.3190670609474182,
-0.26225605607032776,
0.016201818361878395,
0.08658827841281891,
0.06619655340909958,
0.2313942015171051,
-0.014606570824980736,
0.2747609615325928,
-0.31946200132369995,
-0.5321354269981384,
0.3097813129425049,
0.1291743665933609,
0.01718492992222309,
0.1779024451971054,
0.021441921591758728,
-0.2869950234889984,
-0.20230954885482788,
0.20599474012851715,
0.0746043249964714,
-0.043375205248594284,
0.2811829149723053,
0.00891930516809225,
0.07479990273714066,
-0.15319442749023438,
-0.3325469493865967,
0.5541012287139893,
0.23017606139183044,
-0.22550053894519806,
-0.011561110615730286,
0.48681679368019104,
0.612293004989624,
0.02747407928109169,
-0.23240606486797333,
0.4171202480792999,
-0.16594640910625458,
-1.0516911745071411,
0.06431479752063751,
0.11481890082359314,
0.0023654652759432793,
-0.07400623708963394,
-0.7989781498908997,
-0.03694745898246765,
0.008207980543375015,
-0.3419516682624817,
-0.029765300452709198,
0.22924351692199707,
-0.1393669843673706,
-0.001544283702969551,
-0.2699007987976074,
-0.2697612941265106,
-0.17345605790615082,
0.1641618311405182,
0.12273456156253815,
0.11421537399291992,
-0.19562581181526184,
-0.20042672753334045,
0.5048658847808838,
0.5586975812911987,
0.21384049952030182,
-0.2705094516277313,
0.007698443252593279,
0.20386271178722382,
-0.0203812588006258,
0.12303338944911957,
-0.258227676153183,
0.4216424524784088,
-0.3048076927661896,
0.22894951701164246,
0.4528265595436096,
0.4192642569541931,
0.20997752249240875,
0.03493831306695938,
-0.6298673152923584,
-0.03117482364177704,
0.4804786741733551,
0.018358681350946426,
0.1928383857011795,
0.43902042508125305,
0.40857750177383423,
0.46773383021354675,
-0.3140685260295868,
-0.43312549591064453,
0.17249633371829987,
-0.09147009998559952,
-0.7192520499229431,
0.4726092219352722,
0.19899916648864746,
0.1458643525838852,
0.09656210988759995,
-0.11877196282148361,
-0.31802958250045776,
-0.3306697905063629,
0.30388781428337097,
0.48448246717453003,
-0.3188829720020294,
-0.27087390422821045,
0.17914974689483643,
-0.8256872296333313,
0.13808229565620422,
-0.019851457327604294,
-0.905308723449707,
0.6641207337379456,
-0.10012555122375488,
-0.002709466265514493,
0.0008068810566328466,
-0.19452357292175293,
0.12681064009666443,
-0.41516077518463135,
-0.6127867698669434,
-0.38037869334220886,
0.2666069269180298,
-0.28469884395599365,
0.4878891110420227,
0.7558234333992004,
0.5708933472633362,
-0.09762781113386154,
0.034312404692173004,
0.4335387051105499,
0.38348516821861267,
0.2022048830986023,
-0.3188765347003937,
-0.11140438169240952,
0.05054622143507004,
0.7199867367744446,
-0.48734697699546814,
0.05048101767897606,
0.3614926338195801,
0.7951287031173706,
0.06025262922048569,
0.04304826632142067,
-0.45502570271492004,
-0.4225221276283264,
0.40532469749450684,
-0.6059786677360535,
0.3429495394229889,
0.10613806545734406,
-0.04478852078318596,
-0.24390743672847748,
0.08841339498758316,
-0.36137861013412476,
-0.6844369173049927,
0.4817696511745453,
0.38020873069763184,
0.0956525057554245,
-0.18963097035884857,
0.8013750910758972,
0.2599177956581116,
-0.13858076930046082,
0.35267794132232666,
-0.34890952706336975,
0.19212542474269867,
0.4342328906059265,
0.2736137807369232,
-0.13774392008781433,
-0.5697254538536072,
0.4240264892578125,
-0.38164374232292175,
0.22890543937683105,
-0.657039225101471,
0.12344131618738174,
-0.04044732078909874,
0.14382977783679962,
0.2191261649131775,
-0.4063333570957184,
0.09722385555505753,
-0.32333818078041077,
-0.5138916373252869,
-0.06149710714817047,
-0.016612663865089417,
0.05930282920598984,
0.44920504093170166,
0.011381195858120918,
0.07899439334869385,
-0.3713057041168213,
0.5546345710754395,
0.3772019147872925,
-0.15762215852737427,
-0.16776813566684723,
0.18351756036281586,
0.08369861543178558,
-0.28233733773231506,
-0.642453134059906,
-0.02688375674188137,
0.06140757352113724,
-0.2757144272327423,
0.3456902801990509,
-0.276321142911911,
-0.21336688101291656,
0.3287954032421112,
-0.1102638989686966,
0.30265387892723083,
0.01756281778216362,
0.24849271774291992,
0.2940039336681366,
0.746613085269928,
0.3607473075389862,
-0.2580714523792267,
-0.015837445855140686,
0.18119026720523834,
-0.07834790647029877,
-0.08367758244276047,
0.4171571731567383,
0.6492342948913574,
0.10375480353832245,
0.07825670391321182,
0.3976186513900757,
0.8334488272666931,
0.23252259194850922,
-0.07004037499427795,
0.142793208360672,
-0.20378851890563965,
0.23136010766029358,
-0.4016592502593994,
0.7030605673789978,
0.3803503215312958,
-0.2583753168582916,
-0.11455314606428146,
0.1123260036110878,
0.02334059774875641,
-0.210004061460495,
-0.12993203103542328,
-0.2881608307361603,
0.23182877898216248,
0.06311096251010895,
-0.6451656222343445,
-0.5262004733085632,
0.49802839756011963,
-0.6185941696166992,
0.5086306929588318,
0.31669580936431885,
-0.24112479388713837,
-0.03857439383864403,
0.21465829014778137,
-0.713320255279541,
0.14579200744628906,
-0.18757036328315735,
0.6175081729888916,
-0.08179907500743866,
0.1956985890865326,
0.2339065819978714,
0.2783588469028473,
0.1532912403345108,
-0.20635034143924713,
-0.5457849502563477,
-0.056056927889585495,
-0.08310750871896744,
-0.2077959179878235,
0.380619615316391,
-0.44348180294036865,
0.04261985048651695,
0.013396847993135452,
0.12450132519006729,
0.4215128719806671,
-0.7477681040763855,
-0.37066060304641724,
-0.2014303207397461,
-0.4686702489852905,
-0.13695821166038513,
-0.2718440890312195,
-0.3917368948459625,
0.18732231855392456,
-0.03471427783370018,
0.14896956086158752,
0.12334118038415909,
-0.6505226492881775,
0.3962213099002838,
-0.09673424065113068,
0.25617516040802,
0.09720739722251892,
0.06945531815290451,
0.07326238602399826,
0.5791067481040955,
0.3889552056789398,
-0.3194107711315155,
-0.4066213071346283,
-0.1646832823753357,
-0.08517179638147354,
-0.4420980215072632,
0.3305179178714752,
-0.37846100330352783,
-0.16469793021678925,
-0.2757207453250885,
0.3052613437175751,
0.844224750995636,
0.19511787593364716,
-0.8778032660484314,
0.7823408842086792,
-0.08648905158042908,
0.39663219451904297,
0.6352217197418213,
-0.7677680253982544,
0.0016665620496496558,
-0.4091010093688965,
-0.529873788356781,
-0.28190726041793823,
0.6991336345672607,
0.18354809284210205,
0.1475386619567871,
0.24984490871429443,
0.34441953897476196,
0.4588605761528015,
-0.4129701852798462,
0.5700560808181763,
-0.18872544169425964,
-0.30979064106941223,
-0.48900750279426575,
0.535463809967041,
-0.17905521392822266,
0.1421099156141281,
-0.17949919402599335,
0.020478852093219757,
0.220431387424469,
-0.1139214038848877,
0.30468395352363586,
-0.1684286892414093,
-0.12795914709568024,
-0.3371739387512207,
0.18311412632465363,
0.10556820034980774,
-0.21831543743610382,
-0.8262634873390198,
-0.36383065581321716,
0.07720542699098587,
0.3826534152030945,
-0.202617809176445,
0.11548779159784317,
0.29438135027885437,
-0.10431721061468124,
-0.23447178304195404,
-0.3879968225955963,
-0.3634597659111023,
0.1611812710762024,
0.126221165060997
] |
Whether sensory nerve can sense bone density or metabolic activity to control bone homeostasis is unknown. Here we found prostaglandin E2 (PGE2) secreted by osteoblastic cells activates PGE2 receptor 4 (EP4) in sensory nerves to regulate bone formation by inhibiting sympathetic activity through the central nervous system. PGE2 secreted by osteoblasts increases when bone density decreases as demonstrated in osteoporotic animal models. Ablation of sensory nerves erodes the skeletal integrity. Specifically, knockout of the EP4 gene in the sensory nerves or cyclooxygenase-2 (COX2) in the osteoblastic cells significantly reduces bone volume in adult mice. Sympathetic tone is increased in sensory denervation models, and propranolol, a β2-adrenergic antagonist, rescues bone loss. Furthermore, injection of SW033291, a small molecule to increase PGE2 level locally, significantly boostes bone formation, whereas the effect is obstructed in EP4 knockout mice. Thus, we show that PGE2 mediates sensory nerve to control bone homeostasis and promote regeneration. | [
-0.028092797845602036,
0.00837099552154541,
-0.03369956463575363,
0.02195429801940918,
0.00214593019336462,
-0.005307566840201616,
0.016122065484523773,
-0.03152604028582573,
-0.014352883212268353,
0.012249048799276352,
-0.010130572132766247,
0.017543230205774307,
-0.00507409917190671,
0.0262053944170475,
0.00014332379214465618,
0.0041509950533509254,
-0.019364167004823685,
-0.030648522078990936,
0.0058947280049324036,
0.0021660486236214638,
0.020125199109315872,
-0.005147034302353859,
0.012929699383676052,
-0.02086961269378662,
0.0005719317123293877,
0.009213258512318134,
0.023249559104442596,
-0.03202628344297409,
-0.0035157278180122375,
-0.057254575192928314,
0.015575901605188847,
-0.012772966176271439,
0.025239508599042892,
-0.012830764055252075,
-0.009937886148691177,
-0.0032311147078871727,
-0.007992426864802837,
0.037161171436309814,
-0.001961768139153719,
-0.0051806094124913216,
0.0073899030685424805,
-0.018108496442437172,
0.017505072057247162,
0.0183272548019886,
-0.014341508969664574,
-0.020161906257271767,
0.00031362444860860705,
0.016803719103336334,
-0.009517820551991463,
0.007030893582850695,
-0.00035315065179020166,
-0.02121526002883911,
-0.012712609954178333,
0.022703249007463455,
-0.008802365511655807,
0.025051739066839218,
0.023507673293352127,
0.0029817817267030478,
0.0049148304387927055,
-0.021447420120239258,
0.008417481556534767,
-0.007443508133292198,
0.009603981859982014,
-0.018214864656329155,
0.007374551612883806,
-0.06565684080123901,
0.036273080855607986,
-0.05099692940711975,
-0.015383586287498474,
-0.009695064276456833,
-0.02888398803770542,
0.01258442085236311,
-0.014415946789085865,
-0.003008549101650715,
0.011837771162390709,
-0.017483482137322426,
-0.01574002206325531,
-0.01592758111655712,
0.016478434205055237,
0.04284192621707916,
0.011829487979412079,
-0.015989987179636955,
-0.007891983725130558,
0.03383077681064606,
-0.009077613241970539,
0.006598263513296843,
-0.017351513728499413,
-0.018099095672369003,
-0.026380304247140884,
-0.006123539991676807,
0.03475307673215866,
-0.01002645492553711,
0.0545772910118103,
-0.0029059830121695995,
-0.017548538744449615,
0.009166779927909374,
0.007154441904276609,
-0.0067790113389492035,
-0.031396105885505676,
-0.05451140180230141,
-0.013230170123279095,
-0.026235852390527725,
0.019127754494547844,
0.04966968297958374,
-0.006695627234876156,
0.014033839106559753,
0.03630954772233963,
-0.006853575352579355,
0.005938975606113672,
0.016957001760601997,
0.005142576061189175,
-0.01269245520234108,
0.0051008593291044235,
0.026005541905760765,
0.02572633884847164,
-0.003066664095968008,
-0.008922610431909561,
-0.01335044577717781,
0.02432074584066868,
0.00875711627304554,
-0.01889769360423088,
-0.009108379483222961,
-0.008847796358168125,
0.003523549297824502,
0.0021881787106394768,
-0.0015583410859107971,
-0.011937128379940987,
0.011907258071005344,
0.032014183700084686,
-0.014433739706873894,
-0.009861037135124207,
0.003500554943457246,
0.007528223097324371,
0.046066444367170334,
-0.019933084025979042,
-0.0004396269505377859,
-0.043105270713567734,
0.02356146275997162,
0.013482438400387764,
-0.03204655647277832,
0.0360395684838295,
0.013853070326149464,
0.010825185105204582,
0.0062943147495388985,
0.017399482429027557,
-0.002157289767637849,
0.00766355125233531,
-0.006965096108615398,
-0.042574647814035416,
-0.017681917175650597,
0.050249386578798294,
-0.020531050860881805,
0.0009512891992926598,
-0.020994320511817932,
0.014190093614161015,
0.01267923228442669,
-0.051097579300403595,
-0.0004303222522139549,
0.010415630415081978,
0.012752929702401161,
-0.011633253656327724,
0.014073031023144722,
0.0473199188709259,
0.013023223727941513,
-0.027237579226493835,
0.005761770065873861,
0.002632159274071455,
-0.004295258317142725,
-0.019045475870370865,
0.007915964350104332,
-0.0005332473665475845,
-0.028484225273132324,
0.00576934777200222,
0.008685599081218243,
-0.016558660194277763,
-0.014345431700348854,
0.005856500938534737,
0.012260702438652515,
-0.008361328393220901,
0.06549352407455444,
-0.005878470838069916,
-0.04037952795624733,
0.009455343708395958,
0.03164259344339371,
-0.020392252132296562,
-0.009123619645833969,
-0.01870918832719326,
-0.005526202730834484,
0.005953469313681126,
0.017941270023584366,
-0.006409192457795143,
0.05115648731589317,
-0.04050586372613907,
0.028656987473368645,
-0.005446193739771843,
0.0038446541875600815,
0.026452302932739258,
-0.0023014789912849665,
-0.011383596807718277,
-0.00327447522431612,
-0.00660338019952178,
-0.021976184099912643,
0.009790187701582909,
0.004732455126941204,
-0.002009081654250622,
0.015268262475728989,
-0.025607023388147354,
-0.032929927110672,
-0.027613645419478416,
0.00572468526661396,
0.018333125859498978,
-0.024119894951581955,
-0.031538669019937515,
0.002593233250081539,
-0.025741953402757645,
0.011325990781188011,
-0.002402661833912134,
0.0002727750688791275,
-0.017481312155723572,
-0.012750877067446709,
0.0033676617313176394,
0.021267103031277657,
0.05233161151409149,
-0.018966488540172577,
0.04184383898973465,
-0.015191733837127686,
-0.0045855105854570866,
0.02250067889690399,
0.0006714790361002088,
0.03027939237654209,
0.01774723269045353,
-0.007892724126577377,
-0.020271653309464455,
0.006823216564953327,
0.038012873381376266,
0.030281510204076767,
0.02009548619389534,
-0.021307984367012978,
0.022111959755420685,
-0.007911247201263905,
0.006643102504312992,
-0.004406495951116085,
0.00533905066549778,
-0.03900747001171112,
0.043114520609378815,
0.03174710273742676,
-0.006228203419595957,
-0.012562733143568039,
0.05090125650167465,
0.013199475593864918,
0.014262475073337555,
-0.0016447450034320354,
0.018093081191182137,
-0.0011692913249135017,
0.006874957587569952,
-0.05803548917174339,
0.0016799317672848701,
0.004270547069609165,
0.02870473824441433,
-0.010748108848929405,
-0.0000537260202690959,
0.013231411576271057,
0.011583865620195866,
0.01477518118917942,
-0.032983481884002686,
0.014500850811600685,
-0.035010263323783875,
0.02929418534040451,
0.02483564242720604,
0.013375588692724705,
0.009679216891527176,
-0.00921572931110859,
0.0005699155735783279,
-0.08067941665649414,
-0.02213071659207344,
0.011012857779860497,
0.018738767132163048,
0.016738593578338623,
0.0065048267133533955,
0.03613430634140968,
-0.008996577933430672,
-0.005254673771560192,
0.0005963239818811417,
0.0038270829245448112,
-0.014203640632331371,
-0.007760841399431229,
-0.007923859171569347,
-0.016850577667355537,
-0.004277891479432583,
0.017970435321331024,
0.016360053792595863,
0.022256702184677124,
-0.03560204058885574,
0.019318874925374985,
-0.0173999834805727,
0.015402336604893208,
0.032916054129600525,
-0.02075676992535591,
-0.012030311860144138,
0.00948486477136612,
-0.0288956668227911,
-0.0032046905253082514,
0.017335303127765656,
-0.024226032197475433,
0.011204895563423634,
0.0010914271697402,
0.029206305742263794,
0.06552008539438248,
-0.007348456885665655,
0.005770097486674786,
-0.03834879398345947,
-0.03240259736776352,
0.03711880370974541,
-0.02231541834771633,
0.009623028337955475,
0.012236157432198524,
0.003058990463614464,
0.01746581681072712,
0.010729774832725525,
0.01289985328912735,
-0.006163664162158966,
0.027313798666000366,
0.0011177920969203115,
-0.030505456030368805,
0.0030724576208740473,
0.0277540422976017,
0.017575956881046295,
-0.018332958221435547,
-0.0034831869415938854,
-0.019508186727762222,
0.017497841268777847,
-0.005251832772046328,
-0.007372680585831404,
0.019484035670757294,
0.008384574204683304,
0.022006908431649208,
0.009701738134026527,
-0.0026440564543008804,
-0.014111430384218693,
0.02938665635883808,
-0.00036815169733017683,
-0.017544902861118317,
0.015636906027793884,
-0.028225641697645187,
-0.002280348911881447,
-0.01989142782986164,
-0.006767999846488237,
-0.03121505305171013,
-0.006610548123717308,
-0.013897385448217392,
-0.014890722930431366,
-0.013953020796179771,
-0.02761576883494854,
0.01199009083211422,
-0.008285033516585827,
-0.03849213570356369,
-0.022216927260160446,
-0.020601091906428337,
-0.00726473331451416,
0.013016443699598312,
0.023746337741613388,
0.03155204653739929,
-0.01580006815493107,
0.028597231954336166,
0.07028072327375412,
-0.0024357964284718037,
0.010545521974563599,
-0.0006850399076938629,
0.00990341231226921,
-0.005444620735943317,
-0.00021737371571362019,
0.03819769620895386,
0.012449105270206928,
-0.02194550633430481,
-0.0016768996138125658,
0.019705237820744514,
-0.006991255097091198,
-0.0533892847597599,
0.01582317054271698,
-0.0002672942355275154,
0.014295846223831177,
0.026227165013551712,
-0.006481781601905823,
-0.033545102924108505,
-0.022198673337697983,
-0.008669648319482803,
-0.014419314451515675,
0.012362908571958542,
-0.01899797096848488,
0.01363221462816,
0.00021955708507448435,
0.07040955126285553,
0.008854173123836517,
-0.0007014783914200962,
-0.03154340758919716,
0.04341789335012436,
-0.035483695566654205,
0.011091177351772785,
0.00962282158434391,
-0.009413747116923332,
-0.004682076629251242,
0.016766708344221115,
-0.027652183547616005,
0.062181197106838226,
0.0310090072453022,
-0.05768562853336334,
0.021195899695158005,
-0.01537005789577961,
0.025814160704612732,
-0.01382905337959528,
-0.007001238875091076,
-0.013112576678395271,
-0.030201807618141174,
-0.01239222101867199,
0.0451069213449955,
-0.02754439413547516,
-0.04971799999475479,
-0.023206043988466263,
-0.013082046993076801,
-0.04932539910078049,
0.011617239564657211,
-0.006363678723573685,
-0.013201982714235783,
-0.009589027613401413,
0.019793372601270676,
0.041665539145469666,
0.031803734600543976,
0.015157075598835945,
0.01873813569545746,
0.0016789332730695605,
0.010816553607583046,
-0.009231330826878548,
-0.01110029686242342,
0.050324320793151855,
0.019107956439256668,
-0.013544030487537384,
-0.0017509461613371968,
-0.018655989319086075,
-0.012829428538680077,
-0.005377957597374916,
0.0012670350261032581,
-0.014408309012651443,
0.016194064170122147,
0.012763310223817825,
0.006292659789323807,
0.012480108998715878,
-0.018836533650755882,
0.027280494570732117,
-0.003347061574459076,
0.0075521706603467464,
-0.011612347327172756,
-0.027116097509860992,
0.02659251168370247,
0.00791221484541893,
-0.01196531392633915,
0.012332441285252571,
-0.01140816230326891,
0.0016953980084508657,
-0.013936571776866913,
-0.011873145587742329,
0.020587898790836334,
0.006827325560152531,
0.03086750954389572,
-0.004469085950404406,
-0.006059001199901104,
-0.01798173226416111,
0.006463636644184589,
-0.0027304007671773434,
0.013571610674262047,
0.0024981824681162834,
0.00011658528819680214,
0.018027648329734802,
0.008467254228889942,
0.02070184238255024,
-0.007093499414622784,
-0.022012587636709213,
0.028015801683068275,
0.0155043825507164,
-0.07356508076190948,
0.01833890937268734,
-0.004994508810341358,
-0.010438838973641396,
0.0011412694584578276,
0.014136599376797676,
-0.02920907735824585,
-0.009608020074665546,
-0.028748836368322372,
-0.00982943270355463,
0.030098868533968925,
0.015536215156316757,
0.0270485058426857,
0.007883621379733086,
0.01832421123981476,
0.042909909039735794,
0.028098804876208305,
-0.0020416979677975178,
0.01115960069000721,
-0.010457782074809074,
-0.0070015378296375275,
-0.01419464685022831,
-0.009076423943042755,
0.011606790125370026,
-0.012660376727581024,
-0.07925989478826523,
0.008691307157278061,
0.0309981070458889,
0.013040805235505104,
0.010759756900370121,
-0.016955815255641937,
-0.005020152777433395,
-0.002115244045853615,
-0.029923472553491592,
-0.024284547194838524,
0.05036689341068268,
-0.013831723481416702,
0.006890125572681427,
-0.013361025601625443,
-0.002499682828783989,
-0.011189576238393784,
0.023870356380939484,
0.0053093614988029,
-0.01050986722111702,
0.05665801465511322,
-0.007927236147224903,
0.012723201885819435,
-0.013266002759337425,
-0.015915531665086746,
-0.016489557921886444,
-0.025262540206313133,
-0.008636686019599438,
0.015935545787215233,
0.004201105795800686,
-0.030686132609844208,
-0.050474729388952255,
-0.03958702087402344,
-0.027488842606544495,
-0.019252970814704895,
-0.0494021400809288,
-0.03407531976699829,
-0.0018841512501239777,
-0.02806997299194336,
-0.006696327123790979,
-0.03682943060994148,
-0.007182941772043705,
0.016296101734042168,
0.019312722608447075,
0.012859676033258438,
0.011983852833509445,
0.00609216233715415,
0.008458836004137993,
-0.012847565114498138,
0.019189532846212387,
0.003108425298705697,
0.004788530990481377,
0.024383794516324997,
0.002944386098533869,
-0.017515022307634354,
0.01843467727303505,
0.0060037304647266865,
-0.008581152185797691,
-0.002697243355214596,
-0.0002791241277009249,
-0.00030929106287658215,
-0.011127067729830742,
-0.003248273627832532,
-0.012713671661913395,
0.07024586200714111,
0.03422911465167999,
-0.0038807017263025045,
0.011300758458673954,
0.0040645599365234375,
0.006596089340746403,
-0.02898770198225975,
-0.04466932266950607,
-0.019874483346939087,
0.02405158430337906,
0.029340028762817383,
-0.016367625445127487,
-0.04074366018176079,
0.011930384673178196,
0.006311201490461826,
0.011165976524353027,
0.021624531596899033,
-0.012512264773249626,
0.03194655478000641,
0.0037426138296723366,
0.04060366749763489,
-0.0016040049958974123,
0.015918442979454994,
0.02077673189342022,
0.007010806817561388,
0.0020052900072187185,
0.004670337308198214,
0.01959798112511635,
0.0037024531047791243,
-0.009675811976194382,
-0.001412218902260065,
0.007103242911398411,
-0.0037386275362223387,
-0.030278988182544708,
0.026168256998062134,
0.009747020900249481,
0.023098040372133255,
0.011080078780651093,
-0.035148631781339645,
-0.014851788058876991,
-0.03612624853849411,
0.030566416680812836,
-0.002052888972684741,
-0.01783819869160652,
-0.01538048218935728,
-0.005290714092552662,
-0.006384650245308876,
-0.010515068657696247,
0.012436647899448872,
-0.0011163726449012756,
-0.007983075454831123,
0.009567403234541416,
-0.0018808124586939812,
0.006128756329417229,
0.022695472463965416,
-0.010922960937023163,
-0.019457004964351654,
0.014819743111729622,
-0.03441550210118294,
-0.0279700867831707,
0.032663602381944656,
-0.018703732639551163,
0.027963679283857346,
-0.019003432244062424,
0.015949632972478867,
-0.05152786150574684,
-0.016117028892040253,
-0.01663719117641449,
0.0024263241793960333,
0.01791248843073845,
0.007225846406072378,
-0.017853762954473495,
0.012648802250623703,
0.011247603222727776,
0.017428286373615265,
0.005299067590385675,
0.014575817622244358,
0.0039972723461687565,
0.015619207173585892,
0.011522138491272926,
-0.0167294479906559,
0.015718499198555946,
-0.034920431673526764,
0.04260340705513954,
0.007476107683032751,
0.038379594683647156,
-0.015660271048545837,
0.011624515056610107,
-0.004254743456840515,
0.017518922686576843,
0.005869847256690264,
0.006467318627983332,
0.011619682423770428,
0.02163657918572426,
0.01107960008084774,
0.03633922338485718,
0.047470349818468094,
0.0024562098551541567,
-0.02004260942339897,
-0.01146702840924263,
-0.012168138287961483,
-0.022026561200618744,
-0.05985434353351593,
0.0201001837849617,
-0.013018849305808544,
-0.026064299046993256,
0.023803019896149635,
0.002136498922482133,
-0.00902511551976204,
-0.018922775983810425,
0.004271319136023521,
-0.018865160644054413,
-0.014066759496927261,
0.0008932023774832487,
0.009352928027510643,
-0.0061182137578725815,
-0.028748683631420135,
-0.005206138826906681,
0.007045058533549309,
-0.009212869219481945,
-0.005163892172276974,
-0.010144341737031937,
0.0005840742960572243,
-0.005772764794528484,
-0.038033824414014816,
-0.04981514438986778,
-0.02226969413459301,
0.018187502399086952,
-0.006591698154807091,
-0.0032042888924479485,
0.027480442076921463,
-0.03159564360976219,
-0.007512853015214205,
0.014804711565375328,
-0.009509868919849396,
-0.002176472917199135,
0.013133356347680092,
-0.016153432428836823,
-0.01901034638285637,
-0.023042891174554825,
0.016791243106126785,
-0.015538732521235943,
0.003059673123061657,
0.0077039580792188644,
0.007491253316402435,
-0.03964582085609436,
0.027295434847474098,
0.019752295687794685,
0.010238493792712688,
0.0009812141070142388,
0.01213029120117426,
0.00682497164234519,
-0.008524170145392418,
-0.0034651756286621094,
0.010967476293444633,
0.017914945259690285,
0.01575063169002533,
-0.03304125741124153,
-0.00812014564871788,
-0.03293725848197937,
-0.001239741686731577,
-0.001177802449092269,
-0.0015681269578635693,
-0.009086836129426956,
0.03238094598054886,
0.0066824620589613914,
-0.01246248185634613,
-0.04181555658578873,
0.007269334048032761,
-0.02072269655764103,
-0.009641136042773724,
-0.026340745389461517,
-0.04842614382505417,
0.01647692173719406,
-0.04133564978837967,
-0.013575581833720207,
-0.030673978850245476,
-0.002279422013089061,
0.05455455556511879,
0.0215480737388134,
0.003486958332359791,
0.01871439442038536,
0.010851146653294563,
-0.014241084456443787,
-0.01561317965388298,
-0.03013784810900688,
-0.006779763847589493,
-0.016708441078662872,
0.004440695513039827,
0.024994436651468277,
-0.02068619802594185,
0.04030356928706169,
-0.0015763072296977043,
-0.0051602935418486595,
-0.01836353726685047,
-0.027584662660956383,
0.0073403362184762955,
-0.050571292638778687,
0.016954544931650162,
0.012220594100654125,
0.011541828513145447,
0.018277108669281006
] | [
0.059598881751298904,
0.05762675032019615,
0.08002090454101562,
0.3347230851650238,
0.05176010727882385,
0.23718221485614777,
0.33289477229118347,
-0.05877964198589325,
-0.3602246046066284,
-0.352979451417923,
0.10113915055990219,
0.4731189012527466,
-0.048972275108098984,
0.024834023788571358,
0.009663350880146027,
0.2014964073896408,
0.6825748682022095,
0.444378137588501,
-0.4419644773006439,
-0.6139926314353943,
-0.2894158661365509,
-0.019249029457569122,
0.7554594874382019,
0.233892023563385,
-0.05758759379386902,
-0.002951080445200205,
0.12133637070655823,
0.19089019298553467,
0.32745325565338135,
-0.36932066082954407,
-0.29502108693122864,
0.6984714269638062,
-0.325336754322052,
-0.35835209488868713,
-0.7728245258331299,
0.045658089220523834,
-0.37378525733947754,
-0.5564466714859009,
0.008015971630811691,
-0.20749899744987488,
-0.4147213399410248,
-0.06964556127786636,
-0.08407209068536758,
0.5720882415771484,
-0.2586494982242584,
0.2418399155139923,
-1.1520798206329346,
0.7756400108337402,
-0.023799248039722443,
0.3639523684978485,
-0.2746855914592743,
0.4971967339515686,
0.14908866584300995,
-0.07003335654735565,
0.13206061720848083,
-0.07648180425167084,
-1.0873987674713135,
0.000006440070592361735,
0.5787254571914673,
-0.7011491656303406,
-0.10111000388860703,
0.2442239224910736,
-0.4835931360721588,
0.40325865149497986,
-0.12355640530586243,
0.3398820757865906,
-0.09160643070936203,
-0.3659677803516388,
-0.307108998298645,
0.29734110832214355,
0.22659781575202942,
-0.4618256986141205,
0.029317548498511314,
0.28472161293029785,
-0.18223950266838074,
-0.12367379665374756,
-0.4516284465789795,
-0.12020840495824814,
0.2459435909986496,
0.20916840434074402,
0.20024237036705017,
0.16082678735256195,
0.8890313506126404,
-0.19721835851669312,
0.2836872339248657,
0.15477077662944794,
0.1649675965309143,
0.40375852584838867,
-0.3778637647628784,
-0.2985874116420746,
-0.3033713400363922,
0.07122625410556793,
0.5977407693862915,
0.26018989086151123,
-0.30758097767829895,
0.35509032011032104,
0.30401289463043213,
-0.3802288770675659,
0.018076138570904732,
0.3206290304660797,
0.157308891415596,
0.361771821975708,
0.05653554946184158,
-0.46785786747932434,
0.0036471725907176733,
-0.2776760160923004,
0.02034716308116913,
-0.17108838260173798,
-0.6340650320053101,
0.3187550902366638,
-0.9595871567726135,
-0.06913312524557114,
-0.1670960783958435,
-0.3269887864589691,
-0.09410323947668076,
-0.3556520938873291,
-0.08338137716054916,
0.17274880409240723,
-0.41643109917640686,
-0.24966248869895935,
0.12369681149721146,
1.0219063758850098,
-0.20384928584098816,
0.4338286817073822,
0.020492738112807274,
-0.25108808279037476,
0.24916930496692657,
-0.010299380868673325,
0.06526869535446167,
0.6590859889984131,
0.2822628915309906,
0.9452440142631531,
-0.502932071685791,
-0.09701365232467651,
-0.00041762072942219675,
-0.22749829292297363,
0.22332873940467834,
0.5240793228149414,
0.1289953738451004,
-0.12756098806858063,
-0.828039288520813,
-0.39491286873817444,
-0.3758106231689453,
0.228431835770607,
0.053548797965049744,
-0.4004211127758026,
-0.46128058433532715,
0.2463189661502838,
0.34621506929397583,
-0.45793330669403076,
0.07011739164590836,
-0.48315897583961487,
-0.6214984655380249,
-0.1989734023809433,
0.10595649480819702,
0.40988653898239136,
-0.08281923085451126,
-0.3294937312602997,
0.14664366841316223,
-0.1364876627922058,
0.05201224237680435,
-0.5375508666038513,
0.05898349732160568,
0.21423542499542236,
0.4085562229156494,
0.11584089696407318,
0.4523395895957947,
0.43335017561912537,
0.19705837965011597,
0.2475687712430954,
-0.25428545475006104,
-0.45966610312461853,
-0.05305688828229904,
-0.521582305431366,
-0.3881193995475769,
-0.1827520877122879,
-0.23616905510425568,
0.32064467668533325,
-0.11318578571081161,
0.08866460621356964,
-0.8597699403762817,
0.2776932120323181,
-0.5920319557189941,
-0.6864541172981262,
0.34170663356781006,
-0.11595127731561661,
0.5423312187194824,
-0.17766322195529938,
-0.3807569742202759,
-0.5205252170562744,
0.10769175738096237,
-0.35130971670150757,
0.8981425762176514,
-0.4933311641216278,
1.6717530488967896,
-0.3428651988506317,
-0.5702521800994873,
0.7839165329933167,
0.49115070700645447,
-0.04790860041975975,
-0.003515925956889987,
-0.33497104048728943,
0.4374741017818451,
-0.003871862543746829,
-0.48618221282958984,
0.3508014976978302,
0.09899237751960754,
0.04810326173901558,
0.5829236507415771,
0.04143530875444412,
0.0945986732840538,
-0.462796151638031,
0.0803532525897026,
-0.3075391352176666,
0.43385979533195496,
-0.4427338242530823,
-0.3531395196914673,
-0.34493884444236755,
-0.3458039462566376,
-0.07971538603305817,
0.024537580087780952,
-0.327324241399765,
0.5848015546798706,
1.0069810152053833,
-0.2477239966392517,
1.0779730081558228,
0.5123177766799927,
0.13668960332870483,
0.8974745869636536,
-0.39041411876678467,
0.2748451232910156,
-0.5259896516799927,
0.142365500330925,
-0.2595302164554596,
0.023743093013763428,
0.06691015511751175,
0.21571427583694458,
-0.2931443750858307,
0.047725941985845566,
-0.0510178804397583,
-0.0354163758456707,
0.4921172261238098,
-0.5872237682342529,
-0.1616370677947998,
0.15864498913288116,
-0.12390559911727905,
-0.23087194561958313,
0.3198617398738861,
-1.3026204109191895,
-0.07113753259181976,
0.08492013067007065,
0.729171097278595,
0.08726070076227188,
-0.4531552493572235,
0.0363229475915432,
-0.11629315465688705,
-0.15146785974502563,
-0.14593809843063354,
0.34922248125076294,
-0.6371059417724609,
-0.0783887654542923,
-0.16596171259880066,
0.13853682577610016,
0.4823613166809082,
0.30693942308425903,
-0.021116798743605614,
-0.5578331351280212,
-0.3843007981777191,
1.035345435142517,
0.7955777049064636,
0.9982208013534546,
-0.37728285789489746,
-0.8134225010871887,
0.1493293046951294,
0.14021070301532745,
-0.15759821236133575,
-0.30207908153533936,
0.2758731544017792,
-0.3382980227470398,
-0.30758121609687805,
-0.13926640152931213,
0.13510684669017792,
0.8724486827850342,
-0.010510378517210484,
-0.19401846826076508,
-0.10985811799764633,
-0.3998270034790039,
-0.12071038782596588,
-0.10305041074752808,
-0.7898339629173279,
-0.021562913432717323,
0.060173485428094864,
0.018683776259422302,
0.14680500328540802,
0.3231297731399536,
0.32365739345550537,
-0.14719870686531067,
0.353222519159317,
0.5818213224411011,
-0.6901971697807312,
-0.2615348994731903,
0.04286281019449234,
-0.4079113304615021,
-0.15670353174209595,
-0.23799385130405426,
0.3449479937553406,
-0.25870704650878906,
0.26014938950538635,
-5.853895664215088,
0.016309326514601707,
-0.28883644938468933,
-0.2625466585159302,
-0.1861734390258789,
-0.30998778343200684,
0.8750234842300415,
-0.10312473773956299,
0.08869744092226028,
0.5036691427230835,
0.14872010052204132,
0.6547936797142029,
0.23148603737354279,
0.1888091117143631,
-0.3909847140312195,
0.0752410814166069,
-0.3458883762359619,
-0.16826237738132477,
0.5641056299209595,
0.22098520398139954,
0.05559704825282097,
0.11901219934225082,
-0.20860151946544647,
0.5698745846748352,
-0.09971336275339127,
-0.03886530175805092,
-0.5700257420539856,
0.09836062788963318,
-0.0639469251036644,
-0.33185893297195435,
-0.39037033915519714,
-0.7553632259368896,
0.09929168969392776,
0.19295334815979004,
0.6877167224884033,
0.0748872235417366,
0.19994798302650452,
-0.09051944315433502,
-0.2703460454940796,
-0.3356128931045532,
-0.24975581467151642,
0.207317054271698,
-0.25760963559150696,
0.06712093204259872,
0.31328895688056946,
-0.11745608597993851,
-0.16087472438812256,
0.14073029160499573,
-0.1374695748090744,
0.7663495540618896,
0.04142279922962189,
-0.3390098512172699,
0.2582683563232422,
0.23329071700572968,
0.7301489114761353,
0.43895962834358215,
0.5005709528923035,
-0.5226145386695862,
-0.48392510414123535,
0.20307911932468414,
-0.11400924623012543,
-0.0822809711098671,
-0.2041178196668625,
-0.4166974723339081,
0.28846317529678345,
0.669745922088623,
-0.9218849539756775,
-0.696957528591156,
0.19054710865020752,
-0.5347701907157898,
-0.2686993479728699,
-0.09601157903671265,
-0.010593543760478497,
-0.6818245649337769,
0.5252565145492554,
-0.2216624617576599,
-0.0496675968170166,
0.22270219027996063,
-0.07572092860937119,
0.19104912877082825,
-0.191360205411911,
-0.25542861223220825,
-0.2957828938961029,
-0.09406240284442902,
0.1280532330274582,
0.0762682855129242,
-0.06461597234010696,
-0.02864592894911766,
-0.07829800993204117,
0.5337556600570679,
0.6674321889877319,
0.17881222069263458,
0.06080611050128937,
0.6400018930435181,
-0.432847797870636,
0.5522221922874451,
0.37874582409858704,
0.5097891092300415,
0.33211684226989746,
0.13957582414150238,
0.6779993772506714,
-0.021917562931776047,
-0.5755392909049988,
-0.4075775146484375,
-0.39880913496017456,
0.17086176574230194,
-0.4031625986099243,
0.44471466541290283,
0.5954833626747131,
-1.0220880508422852,
0.10601019114255905,
0.15495489537715912,
-0.883719265460968,
-0.2920852303504944,
0.8625817894935608,
-0.3414129316806793,
-0.2570612132549286,
0.29495400190353394,
0.728847324848175,
-0.6783145070075989,
0.376666784286499,
0.4612133800983429,
-0.694385826587677,
-0.04188495874404907,
-0.39052706956863403,
0.0034891776740550995,
-0.20136253535747528,
0.44647830724716187,
-0.48688313364982605,
-0.19825702905654907,
0.1355060338973999,
0.4732740521430969,
0.15898475050926208,
0.595808207988739,
0.17961618304252625,
-0.5638535022735596,
-0.16601377725601196,
0.07173427194356918,
0.5264305472373962,
-0.37386295199394226,
0.2818470895290375,
-0.15282787382602692,
-0.3240654766559601,
-0.32626232504844666,
0.44059252738952637,
-0.011330635286867619,
-0.371774822473526,
-0.05495554953813553,
-0.402410626411438,
0.21302983164787292,
0.33832311630249023,
-0.28314071893692017,
0.09708379954099655,
0.5783025622367859,
-0.5270731449127197,
0.4532565772533417,
0.1189894899725914,
0.08722645044326782,
0.20680879056453705,
-0.5138742923736572,
0.4568963944911957,
0.20267483592033386,
-0.6740151643753052,
0.1417844146490097,
-0.25111743807792664,
-0.5477063059806824,
-0.209342822432518,
-0.6875314712524414,
-0.03265559673309326,
0.09287779778242111,
-0.13442161679267883,
-0.1848258376121521,
0.06228426471352577,
-0.17163704335689545,
0.1480065882205963,
-0.7684096693992615,
-0.5441533923149109,
0.2261420637369156,
-0.19694794714450836,
0.07993947714567184,
0.17174437642097473,
-0.3521318733692169,
-0.12133137881755829,
0.11625302582979202,
0.35692527890205383,
0.15593433380126953,
-0.12205824255943298,
-0.3269338011741638,
-0.10296058654785156,
-0.440070778131485,
0.19219405949115753,
0.20772327482700348,
0.09358630329370499,
-0.03976791724562645,
0.35751965641975403,
0.26639673113822937,
0.4096507132053375,
0.4030107855796814,
-0.04102872312068939,
-0.4351126551628113,
0.3060726225376129,
0.018579930067062378,
-0.17268230020999908,
0.30637091398239136,
0.6305585503578186,
0.14747583866119385,
-0.17380183935165405,
0.2670421600341797,
-0.6802830100059509,
-0.04300706461071968,
0.2145012617111206,
-0.5017997026443481,
0.1639273464679718,
0.26958706974983215,
0.060788583010435104,
-0.23249314725399017,
0.7202338576316833,
-0.4312792420387268,
-0.6065068244934082,
0.4781273901462555,
0.4823946952819824,
0.28295809030532837,
-0.22041431069374084,
-0.34622785449028015,
-0.5053374767303467,
0.15289749205112457,
0.3878122568130493,
-0.5432080030441284,
0.4677272439002991,
0.2171405404806137,
-0.27446699142456055,
-0.055742427706718445,
-0.15657170116901398,
0.17057791352272034,
-0.1810322105884552,
0.23941786587238312,
-0.5871671438217163,
0.06414023786783218,
-0.28514721989631653,
0.5224477052688599,
0.2613723874092102,
0.5529451966285706,
-0.2938445806503296,
0.21254318952560425,
0.02560432255268097,
0.628974199295044,
-0.027210082858800888,
-0.4101625382900238,
-0.35817933082580566,
0.3401692509651184,
0.8648761510848999,
0.03536614403128624,
0.021490413695573807,
0.604377806186676,
0.6672616004943848,
-0.06684967875480652,
0.04257449507713318,
-0.6449187397956848,
-0.06064867600798607,
0.4526709020137787,
-0.15368324518203735,
-0.03207211568951607,
0.20231904089450836,
0.15386952459812164,
0.2199063003063202,
0.11058025807142258,
-0.0791824460029602,
-0.7664697766304016,
0.46954286098480225,
-0.2740812599658966,
0.1943424940109253,
0.3471858501434326,
0.6147543787956238,
0.11221323162317276,
-0.2402118593454361,
0.13038617372512817,
-0.5309766530990601,
-0.09862686693668365,
-0.1484799087047577,
-0.0010942225344479084,
-0.023523176088929176,
-0.6230123043060303,
0.10665971040725708,
-0.6002644300460815,
0.11817716062068939,
-0.6085382103919983,
0.34395018219947815,
-0.6587728261947632,
-0.07472899556159973,
0.006422801874577999,
-0.07589894533157349,
-0.1177181527018547,
-0.2838238477706909,
-0.5483201742172241,
0.2745683789253235,
0.27839645743370056,
-0.15028727054595947,
0.3773195147514343,
-0.17500504851341248,
0.42760875821113586,
-0.4667445421218872,
0.40245264768600464,
0.48514440655708313,
-0.05460014566779137,
-0.3257468342781067,
0.44770506024360657,
0.04300354793667793,
-0.2888531982898712,
-0.6155725121498108,
-0.4269946813583374,
0.050884902477264404,
-0.19463656842708588,
0.05168462172150612,
0.07264941930770874,
-0.390362411737442,
0.3148667812347412,
0.4602677524089813,
0.2846667766571045,
-0.22182726860046387,
0.45186179876327515,
0.24603044986724854,
0.3173685371875763,
0.6444169282913208,
-0.3603668510913849,
0.012476175092160702,
0.17198091745376587,
-0.0963202491402626,
0.13179124891757965,
0.4365690350532532,
0.6249793767929077,
0.9903342127799988,
0.05430653318762779,
0.16162796318531036,
0.8219510912895203,
0.6957615613937378,
0.11982814967632294,
0.20549121499061584,
-0.5660115480422974,
-0.08420228213071823,
-0.054522015154361725,
1.008663296699524,
0.1625961810350418,
-0.19275955855846405,
-0.239024356007576,
0.24883905053138733,
0.6077510118484497,
0.11710847169160843,
0.023715384304523468,
-0.2856829762458801,
0.13889643549919128,
0.18901708722114563,
-0.7679420709609985,
-0.11868895590305328,
0.19920888543128967,
-0.49692055583000183,
0.1361149251461029,
0.21621406078338623,
0.17916031181812286,
-0.6005070209503174,
0.48293405771255493,
-0.5125109553337097,
0.3981024920940399,
0.05860595777630806,
0.5542492270469666,
0.07819660753011703,
-0.027291305363178253,
0.045026641339063644,
0.3164282441139221,
0.14070092141628265,
-0.24775438010692596,
-0.14320369064807892,
0.12060350924730301,
-0.31190866231918335,
0.09671975672245026,
0.14773863554000854,
-0.13032102584838867,
0.05949286371469498,
-0.11030364036560059,
0.2745439410209656,
0.33036524057388306,
-0.46734240651130676,
0.21713948249816895,
-0.49581530690193176,
-0.4056350588798523,
-0.1606660634279251,
-0.49707090854644775,
-0.37070751190185547,
-0.23988062143325806,
-0.024292152374982834,
0.013891487382352352,
-0.462338924407959,
-0.49029549956321716,
0.21706083416938782,
0.011963751167058945,
0.2621181011199951,
0.04837040975689888,
-0.38651975989341736,
0.13506962358951569,
0.21104782819747925,
0.19532814621925354,
-0.1484023630619049,
0.604918897151947,
-0.12279179692268372,
0.2740236818790436,
-0.4683639705181122,
0.5918576121330261,
-0.2728739082813263,
-0.20430691540241241,
-0.7688745260238647,
-0.3181004226207733,
0.8327639698982239,
0.6931924223899841,
-0.26731035113334656,
0.3637053966522217,
0.41662269830703735,
0.39500510692596436,
0.13009154796600342,
-0.36879870295524597,
-0.47699230909347534,
-0.8734321594238281,
-0.17958076298236847,
-0.6945975422859192,
0.4143604636192322,
-0.13599705696105957,
-0.17390722036361694,
0.0922483280301094,
0.6364801526069641,
-0.04743209853768349,
-0.28032976388931274,
-0.14185674488544464,
-0.2301427125930786,
0.026388848200440407,
-0.33307141065597534,
0.36178648471832275,
-0.35221999883651733,
0.23971107602119446,
-0.3762824237346649,
-0.011847047135233879,
-0.11543567478656769,
-0.18409208953380585,
0.35313424468040466,
-0.25169962644577026,
0.17343588173389435,
0.1311691254377365,
0.14077262580394745,
-0.38565927743911743,
-0.5473155379295349,
-0.8647323250770569,
-0.5819313526153564,
0.2562546133995056,
0.2795504033565521,
-0.41428905725479126,
0.029524147510528564,
-0.16076558828353882,
0.06667935848236084,
-0.027804795652627945,
-0.17593993246555328,
-0.3642476499080658,
-0.4613327383995056,
0.054172907024621964
] |
The World Health Organisation has declared the period 2000 to 2010 the Bone and Joint Decade. This is indeed timely and appropriate. Hundreds of millions of people in the world today are beset with a host of disabilities caused by trauma, ageing and degeneration and other affections of the musculo-skeletal system. With the state of art of orthopaedic surgery and rheumatology, sufferers of bone and joint disabilities have benefited a great deal from advances in pharmacology, newer techniques of imaging, surgery and man-made materials to replace diseased or damaged bone and cartilage. However, man-made materials, being non-living, are subject to wear and tear and loosening in the host bone. As we advance into the Bone and Joint Decade, further improvement in the treatment of bone and joint diseases lies in more basic cartilage and bone research. The Human Genome Project has provided us with a better understanding of disease genes and the possibility of gene manipulation to prevent and treat specific diseases. Cartilage cells culture and transplant are already a reality. Tissue engineering, i.e. growing cells in three-dimensional substrates of collagen or synthetic biodegradable polymers, started in the 1980s, will in future be used to replace damaged bone and cartilage parts with living and bone and cartilaginous tissues, respectively. The first steps have been taken; more research needs to be done. And it is not unreasonable to expect a significant breakthrough in the treatment of bone and joint diseases at the end of this decade. Ann Acad Med Singapore 2002; 31:621-2 | [
-0.0076003298163414,
0.01920362561941147,
-0.01669180579483509,
-0.0018203037325292826,
-0.005603048950433731,
0.009196620434522629,
0.007872167974710464,
0.011513770557940006,
-0.010267416015267372,
-0.01897556334733963,
-0.015869416296482086,
0.013657832518219948,
-0.0044469828717410564,
0.0010423590429127216,
0.02122555300593376,
-0.022380832582712173,
-0.019125862047076225,
0.0010568369179964066,
0.017278283834457397,
0.012365242466330528,
-0.0058280895464122295,
0.007628169842064381,
0.009720257483422756,
0.01881556026637554,
-0.012017536908388138,
0.00930708646774292,
0.00389980711042881,
0.008538467809557915,
-0.0037510558031499386,
0.010389920324087143,
-0.0010623775888234377,
0.008702309802174568,
-0.008433593437075615,
0.016229311004281044,
0.0024438120890408754,
0.0014976707752794027,
0.004889205563813448,
0.006724946200847626,
0.009022397920489311,
-0.0035112297628074884,
-0.0006085233762860298,
-0.007389513775706291,
0.005670163780450821,
0.03279461711645126,
-0.009141441434621811,
-0.023105742409825325,
0.0009698622743599117,
-0.0004187016747891903,
0.007487662136554718,
0.01620541512966156,
-0.011845814064145088,
-0.02575070783495903,
-0.0006863081362098455,
-0.007280683144927025,
-0.006305996794253588,
-0.00007789093069732189,
0.019643675535917282,
-0.006672610994428396,
0.00003665592521429062,
-0.006559400819242001,
-0.012043071910738945,
0.006964041851460934,
0.009635685943067074,
-0.0046768514439463615,
-0.0077787116169929504,
-0.06704063713550568,
0.022771567106246948,
0.016420798376202583,
-0.015244122594594955,
-0.016890432685613632,
-0.021148309111595154,
0.01599515601992607,
-0.010416945442557335,
-0.008430907502770424,
0.013428597711026669,
0.019753314554691315,
0.017342396080493927,
0.0010942310327664018,
0.031222229823470116,
0.016655273735523224,
-0.04114872217178345,
-0.009686477482318878,
-0.003164727007970214,
0.011216440238058567,
0.023753724992275238,
0.008780127391219139,
-0.02008705958724022,
-0.01080833189189434,
-0.020120982080698013,
0.01368066668510437,
0.02032717876136303,
-0.017884258180856705,
-0.005443953908979893,
0.014346027746796608,
-0.011657540686428547,
-0.014990322291851044,
-0.0014353245496749878,
0.024599464610219002,
0.0018476275727152824,
-0.0007635252550244331,
-0.006300253793597221,
0.006130766123533249,
0.017494387924671173,
0.02681109309196472,
0.03103409707546234,
0.005940690636634827,
-0.024880915880203247,
-0.00013421778567135334,
-0.015925332903862,
0.007631030399352312,
-0.005149956792593002,
0.0059750741347670555,
-0.0012175277806818485,
0.007772494573146105,
0.024847891181707382,
0.005805830471217632,
0.004749070852994919,
-0.010354889556765556,
0.010711545124650002,
-0.018165327608585358,
0.0013598984805867076,
-0.005817546043545008,
-0.0022202718537300825,
0.00983827468007803,
-0.004360435530543327,
0.004649009555578232,
-0.004969221074134111,
-0.004288944415748119,
-0.0029290448874235153,
-0.0029367816168814898,
-0.005980757065117359,
0.009920574724674225,
0.0061006429605185986,
0.03737819939851761,
0.029393594712018967,
-0.007995576597750187,
-0.05049869418144226,
0.0012890234356746078,
-0.00498531898483634,
-0.0026603699661791325,
0.017668411135673523,
0.0036463295109570026,
-0.002834693994373083,
0.008184504695236683,
0.04194538667798042,
-0.011420343071222305,
-0.0011816911865025759,
0.024112220853567123,
-0.004212412051856518,
0.004559153690934181,
0.022365162149071693,
-0.0026961714029312134,
-0.01565939001739025,
-0.00824541226029396,
-0.0071252984926104546,
0.011168351396918297,
-0.0135550731793046,
-0.0006070128874853253,
-0.0056498097255826,
0.027221929281949997,
-0.021966053172945976,
0.0015526262577623129,
0.001927623525261879,
0.008698657155036926,
0.02318563684821129,
-0.00012347614392638206,
0.019807927310466766,
-0.012243908829987049,
-0.00947644468396902,
0.004805969074368477,
-0.007428023032844067,
-0.029275989159941673,
-0.0039051841013133526,
0.0146558852866292,
-0.018081817775964737,
0.003959894645959139,
0.010280327871441841,
0.010039696469902992,
-0.004066848196089268,
0.06658606976270676,
-0.017526520416140556,
-0.01376053411513567,
-0.018050381913781166,
0.03427569568157196,
0.022028448060154915,
-0.0062569864094257355,
0.0038246717303991318,
-0.016350645571947098,
-0.003251146525144577,
0.005335032008588314,
-0.017792334780097008,
0.007286678999662399,
0.0049091666005551815,
0.006158314645290375,
-0.020784631371498108,
0.0039180731400847435,
0.007381558418273926,
0.004189253784716129,
0.023037314414978027,
0.02284611016511917,
0.04377014935016632,
-0.0076912930235266685,
0.0015028647612780333,
0.005397035740315914,
-0.0047861565835773945,
0.015699870884418488,
0.010737553238868713,
0.002185552380979061,
0.003715203609317541,
0.0012684925459325314,
0.009455962106585503,
-0.007510066032409668,
0.015790242701768875,
-0.007550699636340141,
0.0006085671484470367,
0.006728056818246841,
0.015299716964364052,
0.01709086447954178,
-0.016316741704940796,
-0.013309511356055737,
-0.0010973397875204682,
-0.007208875380456448,
0.01332641951739788,
-0.0022512981668114662,
0.026655856519937515,
0.0008643469773232937,
0.0076146237552165985,
0.011294916272163391,
0.003964675590395927,
-0.005992210004478693,
-0.009445511735975742,
0.016460813581943512,
-0.005992156453430653,
-0.008735043928027153,
-0.01117689162492752,
0.020266856998205185,
0.009797354228794575,
-0.006250049918889999,
0.01833159849047661,
-0.018126532435417175,
-0.01641380786895752,
-0.0009035936091095209,
0.0108950175344944,
-0.00886988453567028,
0.03137116879224777,
-0.013900515623390675,
-0.012407475151121616,
-0.0021360917016863823,
0.0184562299400568,
0.00420605530962348,
0.004049837589263916,
-0.026192568242549896,
0.012873639352619648,
0.03268133103847504,
-0.0015943099278956652,
0.00533303152769804,
-0.01696394942700863,
-0.00462665781378746,
0.02584047242999077,
-0.024183224886655807,
-0.0018674612510949373,
0.007481890264898539,
0.025638790801167488,
-0.018809964880347252,
0.010957150720059872,
-0.01816004328429699,
0.018369611352682114,
-0.017449667677283287,
0.005386012606322765,
-0.023000266402959824,
0.00544213829562068,
-0.007140038534998894,
0.00012804404832422733,
-0.08211155235767365,
-0.008319828659296036,
0.0043047945946455,
0.005968206096440554,
0.012027319520711899,
-0.01748991571366787,
-0.01009537372738123,
0.006792573723942041,
-0.01522169727832079,
0.006055898033082485,
0.0009759910171851516,
-0.009952555410563946,
-0.0009243973763659596,
0.02264905348420143,
-0.021536052227020264,
-0.002720894757658243,
0.0017676455900073051,
0.016295118257403374,
0.006038341671228409,
0.014863532036542892,
-0.001672925427556038,
0.0031485978979617357,
-0.015193434432148933,
-0.001477549085393548,
-0.01997685618698597,
-0.01162974163889885,
0.026357686147093773,
0.014655739068984985,
-0.007480840664356947,
0.012865309603512287,
0.004113286733627319,
-0.006017225794494152,
0.02223888225853443,
-0.001550490502268076,
0.011561776511371136,
-0.003172143828123808,
0.006865866482257843,
-0.01122414879500866,
0.00878141913563013,
0.008457914926111698,
0.004604424349963665,
0.004569647833704948,
0.029134441167116165,
-0.00494067557156086,
0.00012231315486133099,
-0.010468966327607632,
0.012779271230101585,
-0.0037630219012498856,
0.007986918091773987,
-0.019604040309786797,
-0.0046534123830497265,
-0.00591278076171875,
-0.011593416333198547,
0.007248824927955866,
-0.01861359365284443,
-0.021016009151935577,
-0.02031259424984455,
-0.012579458765685558,
-0.007821674458682537,
0.004438828676939011,
-0.010714258998632431,
-0.010554910637438297,
0.019015170633792877,
-0.0071467142552137375,
-0.01679489202797413,
-0.023737050592899323,
0.0056775230914354324,
-0.04015142470598221,
-0.020541168749332428,
0.02010391652584076,
0.010754482820630074,
-0.002178048714995384,
0.006487211212515831,
-0.00800961721688509,
0.010269722901284695,
-0.007438693195581436,
-0.01807509921491146,
0.008816882967948914,
0.028905384242534637,
0.02700035646557808,
-0.0362553671002388,
-0.0030404699500650167,
-0.004824298433959484,
0.009745880961418152,
-0.01388833113014698,
0.003443637862801552,
0.011233619414269924,
-0.006735917646437883,
0.00867769680917263,
-0.006854314357042313,
-0.016927404329180717,
0.007072839420288801,
-0.005371459294110537,
0.007271271664649248,
0.0221649631857872,
-0.007902279496192932,
-0.0025824904441833496,
-0.013306776061654091,
-0.02809271775186062,
0.007770726457238197,
0.02997199073433876,
-0.00376749481074512,
0.017691200599074364,
-0.01367809996008873,
0.00982664991170168,
0.015314748510718346,
0.007336720824241638,
0.017206847667694092,
-0.004613339435309172,
-0.01062236912548542,
-0.0018144394271075726,
0.009713001549243927,
-0.0021477662958204746,
-0.005432716570794582,
0.013465078547596931,
0.009678038768470287,
-0.0035343619529157877,
0.0004306766204535961,
0.07219521701335907,
0.0013433448038995266,
-0.0035710246302187443,
-0.009946323931217194,
0.03995031490921974,
-0.0031197769567370415,
-0.014054183848202229,
0.004700039513409138,
0.022705594077706337,
-0.01757114753127098,
0.01369219645857811,
0.018986422568559647,
-0.02113623544573784,
-0.007787475828081369,
-0.014972390606999397,
0.0009304631967097521,
0.006152982823550701,
-0.0073241787031292915,
-0.008503254503011703,
-0.03182088956236839,
-0.0017268271185457706,
-0.014287417754530907,
-0.0199620071798563,
0.008721727877855301,
-0.01820271834731102,
-0.014596435241401196,
0.014218656346201897,
-0.009401792660355568,
0.0016637040534988046,
0.007331482600420713,
-0.006689498201012611,
0.03989693149924278,
-0.005484125576913357,
0.00637539429590106,
0.03674427792429924,
-0.01530464831739664,
0.0034266558941453695,
0.000337852630764246,
-0.01099882647395134,
-0.0031713838689029217,
-0.029138272628188133,
-0.009708629921078682,
0.01049146056175232,
0.005679340101778507,
0.0058598085306584835,
0.021987568587064743,
-0.007404555566608906,
-0.008725466206669807,
-0.004209497943520546,
-0.00177324702963233,
-0.006801567040383816,
0.008646718226373196,
0.008801227435469627,
-0.028303980827331543,
-0.0018658482003957033,
-0.030155623331665993,
0.009325403720140457,
-0.0018812838243320584,
0.012913952581584454,
-0.0005238456651568413,
-0.005580104887485504,
0.026835132390260696,
0.013696662150323391,
-0.020145274698734283,
0.002011061878874898,
-0.001334840664640069,
0.0055274972692132,
-0.01445109024643898,
0.00014591729268431664,
0.007466975133866072,
-0.012172441929578781,
0.025577543303370476,
-0.023998912423849106,
-0.014555394649505615,
-0.011211146600544453,
-0.01764511875808239,
-0.003239542245864868,
-0.002557086758315563,
0.01719805970788002,
-0.01778223365545273,
-0.0044761281460523605,
-0.006725686602294445,
-0.008737629279494286,
0.004003298934549093,
0.0007028478430584073,
0.00974838063120842,
-0.01905958354473114,
-0.07501569390296936,
0.00432365108281374,
-0.0062958369962871075,
-0.007590144872665405,
-0.010182803496718407,
-0.02259889245033264,
-0.007637928240001202,
-0.024942563846707344,
0.01974410004913807,
-0.0008112224750220776,
-0.008731672540307045,
-0.008874308317899704,
-0.016003038734197617,
-0.0017453111940994859,
0.014572788961231709,
0.007984008640050888,
-0.0003138757310807705,
0.01550152525305748,
0.005735119804739952,
0.00903884693980217,
0.013160163536667824,
-0.012417932040989399,
0.009312452748417854,
-0.006989816203713417,
-0.007976412773132324,
-0.08109067380428314,
0.02084529399871826,
-0.007930467836558819,
-0.007320219650864601,
-0.014136360026896,
-0.00811302661895752,
0.008090068586170673,
-0.007644576020538807,
0.003872911212965846,
-0.01346136350184679,
-0.010711954906582832,
-0.005962250754237175,
0.020800909027457237,
0.00441404152661562,
0.00706709548830986,
-0.01035119779407978,
0.0006205948302522302,
0.027765505015850067,
-0.03374611213803291,
0.016107527539134026,
0.004788650665432215,
-0.01618611253798008,
-0.0039174314588308334,
-0.002187944483011961,
-0.01879095286130905,
-0.02462398260831833,
-0.003153589554131031,
0.007531897630542517,
0.0019896081648766994,
-0.013896485790610313,
-0.01054360717535019,
-0.010123584419488907,
0.002228589728474617,
-0.021523524075746536,
0.016365062445402145,
-0.006537213921546936,
0.013766514137387276,
-0.0063440739177167416,
-0.007299583405256271,
-0.004371703136712313,
-0.004543196875602007,
0.01576167717576027,
-0.01888464018702507,
-0.003356451168656349,
0.007455215789377689,
-0.016994372010231018,
0.009544389322400093,
-0.005979921203106642,
0.0121195949614048,
-0.03388481214642525,
-0.0045349751599133015,
-0.006748800165951252,
-0.00004169531166553497,
-0.0033387087751179934,
-0.002709996188059449,
0.00004857964813709259,
-0.0031644427217543125,
0.006168053485453129,
0.011428307741880417,
0.006574966013431549,
0.007818412035703659,
-0.001711050746962428,
-0.009095903486013412,
0.07125614583492279,
-0.02262495830655098,
0.005658261012285948,
0.00023598200641572475,
0.004753369837999344,
-0.0027490933425724506,
-0.020335152745246887,
-0.006930944509804249,
0.012647220864892006,
0.022929424419999123,
-0.01996132917702198,
-0.013818705454468727,
-0.014273826964199543,
0.004700774326920509,
0.02987276390194893,
-0.027400357648730278,
0.014533973298966885,
-0.010587016120553017,
0.0004575350321829319,
-0.01008121483027935,
0.020993322134017944,
0.007910128682851791,
-0.01092634815722704,
-0.004836958833038807,
-0.002212642692029476,
0.0010926551185548306,
-0.015999067574739456,
-0.011672360822558403,
-0.0025789381470531225,
0.009034255519509315,
-0.012674436904489994,
-0.005342403892427683,
0.004795852117240429,
0.002943449653685093,
0.02671015076339245,
0.01524721086025238,
0.01723708212375641,
0.006008126772940159,
-0.03468756377696991,
0.002640285762026906,
-0.008733254857361317,
-0.011170418933033943,
0.013475878164172173,
-0.012234526686370373,
-0.002209258731454611,
0.012339510954916477,
0.0016543688252568245,
0.014635995961725712,
0.01169833354651928,
-0.005031075328588486,
0.01939822919666767,
0.002799066947773099,
0.012903286144137383,
0.0024034867528826,
0.003500135149806738,
0.026791594922542572,
-0.014054185710847378,
0.019911427050828934,
0.004049524664878845,
-0.013088525272905827,
-0.0006142295897006989,
-0.0010493450099602342,
-0.006403093691915274,
-0.02429432049393654,
-0.0016385249327868223,
0.000998648814857006,
0.019277423620224,
-0.016385797411203384,
-0.012714060954749584,
0.009871774353086948,
0.002409655135124922,
0.010523086413741112,
0.004648212343454361,
0.009447961114346981,
-0.005373086780309677,
0.013241080567240715,
-0.018146028742194176,
-0.03247975558042526,
0.016689321026206017,
0.007943067699670792,
0.001570005901157856,
0.01840231381356716,
0.041274189949035645,
0.0018114312551915646,
0.006859063636511564,
0.009208879433572292,
-0.012376438826322556,
0.0016249492764472961,
-0.007215302437543869,
0.013356432318687439,
0.002169594634324312,
0.007896527647972107,
-0.0015134107088670135,
0.038438476622104645,
0.017210744321346283,
0.03590509295463562,
0.012009428814053535,
0.007800264749675989,
-0.0003501413157209754,
0.007501234766095877,
0.0068716201931238174,
-0.012509332038462162,
-0.00800876971334219,
0.01268674060702324,
-0.023787086829543114,
-0.0036902278661727905,
0.016827739775180817,
0.0005263211205601692,
-0.015978233888745308,
0.019272975623607635,
-0.03007960133254528,
0.0124419666826725,
-0.009091442450881004,
0.033597275614738464,
0.006093395408242941,
0.005036904476583004,
-0.011757699772715569,
-0.009629041887819767,
0.017087921500205994,
-0.015409926883876324,
-0.013653100468218327,
-0.0011495128273963928,
0.009067606180906296,
0.007192371878772974,
-0.036113593727350235,
-0.016231130808591843,
-0.008076941594481468,
-0.002838068176060915,
-0.005069351755082607,
-0.00428313622251153,
0.0035933179315179586,
0.0023506800644099712,
-0.008715351112186909,
0.002481517381966114,
0.020531294867396355,
0.010633980855345726,
-0.008480548858642578,
-0.02168126590549946,
0.00045372307067736983,
-0.01822686567902565,
-0.0021715108305215836,
0.01306065171957016,
-0.00022076419554650784,
0.018946172669529915,
0.010586326010525227,
0.025616511702537537,
0.009155340492725372,
-0.023621821776032448,
0.015822911635041237,
0.012776333838701248,
0.004764980170875788,
-0.001759807695634663,
0.01747371070086956,
0.00010047247633337975,
-0.022166216745972633,
0.019509539008140564,
0.005335926078259945,
0.021333947777748108,
-0.010113892145454884,
-0.004550698213279247,
0.00003296928480267525,
-0.008391374722123146,
0.029064953327178955,
0.0030974142719060183,
0.006324791349470615,
-0.005387437529861927,
0.005686852615326643,
-0.020527126267552376,
-0.006592553574591875,
0.014646228402853012,
-0.011236447840929031,
-0.004176538437604904,
-0.007955359295010567,
0.02718072198331356,
-0.0003117527812719345,
-0.010279427282512188,
-0.023754168301820755,
-0.012190861627459526,
-0.015702327713370323,
0.005513093434274197,
0.011178489774465561,
0.01158720813691616,
0.004928852431476116,
-0.0063127255998551846,
-0.01714204251766205,
0.013784593902528286,
-0.01530878059566021,
0.0008568933699280024,
-0.00934718456119299,
-0.031555917114019394,
0.006871682126075029,
-0.0014277799054980278,
-0.00045368194696493447,
-0.018874745815992355,
0.0066704703494906425,
0.009937901049852371,
0.018476543948054314,
0.007198609411716461,
-0.009112680330872536,
-0.005696069449186325,
0.014410078525543213,
-0.01179799810051918
] | [
0.13615690171718597,
0.33152684569358826,
-0.15010793507099152,
-0.19729506969451904,
-0.37337860465049744,
0.3313598036766052,
0.35095536708831787,
0.411498099565506,
-0.34420284628868103,
-0.9264525175094604,
0.15737125277519226,
0.5800240635871887,
0.4704743027687073,
0.7143053412437439,
-0.36028680205345154,
0.511706531047821,
0.2235899120569229,
-0.19466178119182587,
-0.08489919453859329,
-0.07750168442726135,
-0.3479415774345398,
-0.18600738048553467,
0.45192718505859375,
-0.039621587842702866,
-0.01645968295633793,
-0.09301593154668808,
0.25972652435302734,
-0.1176740750670433,
-0.0257770586758852,
-0.19709520041942596,
-0.08582861721515656,
0.6055415868759155,
-0.19049495458602905,
0.22430747747421265,
0.07561682164669037,
-0.05451977252960205,
0.11880014836788177,
-0.16270744800567627,
0.6120882034301758,
-0.7224212288856506,
0.13366717100143433,
-0.3286631405353546,
0.1690191626548767,
0.43429234623908997,
-0.46666380763053894,
0.11046838015317917,
-1.3881850242614746,
0.6715970039367676,
-0.314684122800827,
0.07594899833202362,
-0.4392387270927429,
0.02550860121846199,
0.5641946196556091,
0.023477694019675255,
-0.16875720024108887,
0.2325335592031479,
-0.3636588752269745,
0.0358312614262104,
-0.33470043540000916,
-0.24235109984874725,
0.5786054134368896,
-0.36180076003074646,
-0.2659580111503601,
0.10121966898441315,
-0.6983560919761658,
0.05311668664216995,
0.7197849154472351,
0.3462264835834503,
-0.13667301833629608,
-0.27642059326171875,
0.1088670864701271,
-0.45060646533966064,
-0.24900828301906586,
0.3676149547100067,
-0.3336260914802551,
-0.6005078554153442,
-0.22036537528038025,
-0.424472838640213,
0.6093456745147705,
-0.32247933745384216,
0.6171390414237976,
-0.16355234384536743,
0.7562248706817627,
-0.47110921144485474,
0.28742003440856934,
-0.00665066484361887,
0.036877501755952835,
0.3810177743434906,
-0.6900818943977356,
0.003486539237201214,
0.12431991845369339,
-0.2831313908100128,
0.9672109484672546,
0.3238566219806671,
-0.10755190253257751,
0.21236637234687805,
0.4044370651245117,
-0.363182008266449,
0.19062210619449615,
-0.19729648530483246,
0.6672777533531189,
-0.2377626895904541,
-0.2967515289783478,
-0.26562243700027466,
0.08169500529766083,
-0.3946138024330139,
0.0836663544178009,
-0.3612942397594452,
0.2809700071811676,
-0.12949688732624054,
-0.32829558849334717,
0.19120873510837555,
-0.1811515986919403,
0.12714074552059174,
-0.10055556148290634,
0.06892035901546478,
0.0575680173933506,
-0.3203122913837433,
-0.3617711365222931,
-0.2136974334716797,
-0.2111881822347641,
-0.07032404094934464,
-0.09446659684181213,
-0.016646819189190865,
-0.13435842096805573,
0.4223984181880951,
0.15824921429157257,
0.14091148972511292,
-0.2631789445877075,
-0.034652311354875565,
0.20939941704273224,
0.33750733733177185,
-0.6151333451271057,
-0.6658816933631897,
0.4779248833656311,
-0.1618230938911438,
0.28616926074028015,
0.4031117260456085,
0.3299979269504547,
0.07785604894161224,
0.3273945450782776,
-0.7348755598068237,
-0.7230337262153625,
0.210399329662323,
-0.0664907693862915,
-0.2827088534832001,
0.2051987498998642,
0.08431963622570038,
-0.34110352396965027,
-0.17578625679016113,
-0.03480644151568413,
0.2306310534477234,
-0.5738185048103333,
0.04650747403502464,
0.337653249502182,
0.32015249133110046,
-0.4259525239467621,
-0.5192038416862488,
0.2381577044725418,
-0.00928515661507845,
0.39494484663009644,
-0.371506005525589,
-0.44280242919921875,
-0.3913109302520752,
0.07733827084302902,
-0.2164769321680069,
0.4835455119609833,
0.16586609184741974,
0.1845329850912094,
0.08581484109163284,
-0.18265123665332794,
-0.13992297649383545,
0.18863965570926666,
-0.43993306159973145,
-0.5063557028770447,
0.530868649482727,
1.0232616662979126,
0.2727622985839844,
-0.1836376190185547,
0.18779371678829193,
-0.6607108116149902,
-0.2740297317504883,
0.3100392520427704,
0.41677436232566833,
0.7963843941688538,
-0.35814398527145386,
0.5407205820083618,
-0.042162686586380005,
-0.23065148293972015,
0.5710065364837646,
-0.5957167148590088,
-0.1124061867594719,
0.321311354637146,
-0.6019359827041626,
1.1789569854736328,
-0.16173964738845825,
-0.16191166639328003,
0.7695159316062927,
-0.44108715653419495,
0.23617295920848846,
-0.38642650842666626,
0.2816990315914154,
0.7041241526603699,
0.06721140444278717,
-0.6840621829032898,
-0.0820077508687973,
0.002566470066085458,
-0.05022968351840973,
-0.3417215943336487,
0.04998473823070526,
0.6698591709136963,
-0.23468559980392456,
-0.4230234622955322,
0.057188376784324646,
-0.0005147276096977293,
0.22337926924228668,
0.2952289879322052,
0.1337699592113495,
-0.7395892143249512,
-0.2011433243751526,
0.5262705683708191,
-0.29266852140426636,
0.3307752311229706,
-0.20120136439800262,
0.39829158782958984,
0.3967876732349396,
0.36249780654907227,
0.4491874575614929,
0.6240195035934448,
-0.5246314406394958,
0.05921534448862076,
-0.30150970816612244,
0.461582213640213,
-0.2462679147720337,
0.34633970260620117,
0.011489513330161572,
0.08380089700222015,
-0.4400355815887451,
0.17725305259227753,
-0.5468434691429138,
0.34730562567710876,
-0.03157352656126022,
-0.14249835908412933,
0.6428260207176208,
0.0881742462515831,
0.0298305731266737,
0.03861147165298462,
0.29682648181915283,
-1.2568730115890503,
-0.2604774832725525,
0.4711083769798279,
0.8460496068000793,
0.4567049443721771,
0.3339284658432007,
-0.05458534136414528,
-0.17408333718776703,
0.32900652289390564,
-0.08608599007129669,
0.38772156834602356,
-0.24919331073760986,
-0.04496535658836365,
-0.33666133880615234,
0.6162868142127991,
0.12427365779876709,
-0.3715006411075592,
-0.5465970635414124,
-0.42450612783432007,
-0.678440511226654,
0.20649945735931396,
-0.22011594474315643,
0.31752753257751465,
0.23530399799346924,
-0.12291420251131058,
0.4540085196495056,
0.17646513879299164,
-0.22554831206798553,
0.11267978698015213,
0.5258073210716248,
-0.6276177167892456,
-0.19689039885997772,
0.24859718978405,
0.6031177639961243,
0.49223053455352783,
-0.5692782402038574,
-0.4662014842033386,
-0.34134677052497864,
-0.0022034638095647097,
-0.247421532869339,
-0.2918570041656494,
0.016160424798727036,
0.06233979016542435,
0.7300653457641602,
-0.10190332680940628,
-0.05072077736258507,
0.38282856345176697,
0.19591210782527924,
-0.2919846177101135,
-0.06546083837747574,
0.49232253432273865,
-0.02961934544146061,
-0.00878541823476553,
0.14945471286773682,
0.045305270701646805,
-0.3227989375591278,
-0.34503093361854553,
-0.1713329553604126,
-0.044287919998168945,
-0.08205258101224899,
-6.052268028259277,
-0.1384868621826172,
-0.4618869423866272,
-0.31531503796577454,
-0.37707629799842834,
0.01023036614060402,
0.8799231648445129,
0.28328993916511536,
-0.19496886432170868,
-0.20296494662761688,
0.505494236946106,
0.38730040192604065,
0.25773537158966064,
0.6063790321350098,
-0.19521351158618927,
0.34781527519226074,
0.20074355602264404,
0.21651390194892883,
-0.43545424938201904,
0.34056296944618225,
0.5858539938926697,
-0.707877516746521,
-0.3285202383995056,
0.12667252123355865,
0.36073580384254456,
-0.11507713049650192,
-0.3269459903240204,
0.11368535459041595,
-0.40874210000038147,
-0.10681832581758499,
0.01474851369857788,
-0.19897662103176117,
0.4166560769081116,
0.02668301947414875,
0.566016435623169,
0.20225892961025238,
-0.01891171932220459,
0.13800905644893646,
0.22688686847686768,
-0.625673234462738,
-0.33055025339126587,
0.0731455534696579,
0.03847004473209381,
-0.3494859039783478,
0.3812867999076843,
0.16144442558288574,
0.30673277378082275,
0.3851686716079712,
0.004458571318536997,
0.7652454972267151,
0.04418574646115303,
-0.1777600646018982,
-0.31802448630332947,
-0.06429710239171982,
0.14043521881103516,
-0.3148069977760315,
-0.04449813812971115,
0.36128294467926025,
0.08655913174152374,
0.2558749318122864,
0.1498638540506363,
-0.32401424646377563,
0.16160260140895844,
-0.8939800262451172,
-0.22125151753425598,
0.1684383600950241,
-1.0329225063323975,
-0.440869003534317,
-0.20610377192497253,
0.4396821856498718,
-0.09750085324048996,
-0.19374634325504303,
-0.2590007483959198,
-0.46690478920936584,
0.01750951074063778,
-0.5674970149993896,
0.1495344489812851,
0.5357055068016052,
-0.5885608792304993,
0.07138899713754654,
-0.15539409220218658,
-0.7601075768470764,
-0.01442420482635498,
-0.016010385006666183,
0.399050235748291,
-0.36498352885246277,
0.11929267644882202,
-0.37293896079063416,
-0.021564900875091553,
0.270568311214447,
0.5565906167030334,
-0.6515251994132996,
-0.20637474954128265,
0.3526245653629303,
-0.18087857961654663,
0.13762642443180084,
-0.08462290465831757,
0.5391536355018616,
-0.015159666538238525,
-0.07657352834939957,
0.05643089860677719,
-0.18214541673660278,
0.13180479407310486,
-0.3857600688934326,
-0.026666153222322464,
-0.11596130579710007,
0.006834821309894323,
0.2039528787136078,
0.78729248046875,
-0.0593915693461895,
-0.14966623485088348,
0.032273247838020325,
-0.36202487349510193,
-0.2636009752750397,
0.2634827196598053,
-0.5303742289543152,
0.009747586213052273,
-0.15970192849636078,
0.2423768788576126,
-0.0060961381532251835,
0.04718492925167084,
0.1273675113916397,
-0.07814155519008636,
0.22745509445667267,
0.3384806513786316,
0.0976872369647026,
-0.37941718101501465,
0.19462139904499054,
-0.1974053829908371,
0.21296942234039307,
0.2667671740055084,
1.1765668392181396,
0.08735597133636475,
0.09243597835302353,
0.30675897002220154,
-0.07094494253396988,
0.047425370663404465,
0.0632588341832161,
-0.16560567915439606,
-0.49506908655166626,
0.5039421916007996,
0.13939636945724487,
-0.281525582075119,
-0.4363499879837036,
0.024908212944865227,
0.34118372201919556,
-0.014917113818228245,
-0.5226017236709595,
-0.23010873794555664,
0.4015049934387207,
0.411634624004364,
0.16175371408462524,
-0.5906063318252563,
0.31887927651405334,
-0.35387641191482544,
0.46948757767677307,
0.7195519208908081,
-0.035393569618463516,
-0.05153046175837517,
-0.6239603161811829,
0.03173081576824188,
0.2757764756679535,
-0.7947523593902588,
-0.11594951152801514,
0.6525163650512695,
-0.14222721755504608,
0.09779042750597,
-0.2394605129957199,
-0.03486109524965286,
0.27852433919906616,
0.31878751516342163,
-0.10320179909467697,
-0.7058424353599548,
-0.04864361882209778,
-0.2551770806312561,
-0.22790010273456573,
-0.15292437374591827,
0.018509937450289726,
0.14443236589431763,
0.02518583834171295,
0.2639099955558777,
-0.22733590006828308,
-0.16222967207431793,
0.18531182408332825,
0.17154476046562195,
-0.1101839542388916,
-0.26308417320251465,
-0.2205023467540741,
-0.32195308804512024,
-0.16134506464004517,
1.0252207517623901,
0.13968029618263245,
0.11463496834039688,
-0.10002678632736206,
0.1521838754415512,
-0.6375060677528381,
-0.27901333570480347,
0.5333649516105652,
-0.030170582234859467,
-0.026865102350711823,
-0.08985014259815216,
0.5506147742271423,
-0.3103998899459839,
0.0627177432179451,
0.8345485329627991,
-0.5632384419441223,
-0.1787574291229248,
-0.007529762107878923,
-0.02734832838177681,
0.021233035251498222,
-0.5527132749557495,
-0.2500513195991516,
0.32651805877685547,
0.4171614348888397,
0.04154420271515846,
0.21551395952701569,
0.19636018574237823,
-0.30386441946029663,
-0.4449370503425598,
0.11636652052402496,
0.4384613633155823,
0.4069376587867737,
-0.36593443155288696,
-0.13893310725688934,
-0.3152049481868744,
-0.18848900496959686,
0.0972430408000946,
-0.33936890959739685,
-0.27298521995544434,
-0.015901906415820122,
-0.3947882354259491,
0.06347186118364334,
0.33728867769241333,
-0.1721658706665039,
-0.36597320437431335,
-0.027373693883419037,
-0.35776492953300476,
0.012639064341783524,
-0.17383798956871033,
0.37493687868118286,
-0.03249330818653107,
0.1868598610162735,
-0.08558608591556549,
-0.3673853576183319,
-0.5321270823478699,
0.03455285355448723,
0.02382541634142399,
-0.06926843523979187,
-0.29659754037857056,
0.1397152841091156,
-0.6923174262046814,
0.15049272775650024,
-0.35312122106552124,
-0.47246691584587097,
0.24592117965221405,
0.02438216656446457,
-0.2065705955028534,
-0.5373109579086304,
-0.47196418046951294,
-0.30669209361076355,
0.19831550121307373,
-0.10846713185310364,
0.015096564777195454,
0.10601334273815155,
0.3389296531677246,
0.546843409538269,
-0.12236235290765762,
-0.514916718006134,
0.4982050359249115,
-0.15685135126113892,
0.08900166302919388,
0.19069409370422363,
0.025570668280124664,
-0.04882572591304779,
0.2702779173851013,
-0.29686063528060913,
-0.21048776805400848,
-0.15477478504180908,
-0.2022111415863037,
-0.3393819332122803,
0.4640001356601715,
0.18536338210105896,
0.0014236513525247574,
-0.05085405707359314,
0.2034069150686264,
-0.6936073899269104,
0.32799774408340454,
-0.2358238697052002,
-0.1574951857328415,
-0.6733409762382507,
0.15449336171150208,
0.23988564312458038,
-0.6118552684783936,
-0.07058420032262802,
-0.22031466662883759,
0.13144156336784363,
0.1824106127023697,
0.2542775869369507,
-0.38668566942214966,
-0.3088034391403198,
-0.03419310972094536,
0.701620876789093,
0.596530556678772,
-0.6503399014472961,
-0.07700800895690918,
-0.14184464514255524,
0.5045119524002075,
0.6352885365486145,
-0.020647214725613594,
0.6285067796707153,
0.5837346315383911,
-0.0846937745809555,
0.20368529856204987,
1.049597978591919,
-0.7236459255218506,
0.08661198616027832,
0.019178159534931183,
0.28268325328826904,
0.4221479892730713,
0.33381885290145874,
-0.3826791048049927,
0.6575171947479248,
0.21602566540241241,
-0.0381823368370533,
-0.2663818597793579,
0.3247479498386383,
-0.08848539739847183,
0.23047515749931335,
0.08808625489473343,
0.829082190990448,
0.16822965443134308,
0.4159862995147705,
-0.14567512273788452,
0.2753329575061798,
0.3977108597755432,
-0.2775358259677887,
0.1465861201286316,
-0.04619917273521423,
-0.31648218631744385,
0.21761371195316315,
1.1859010457992554,
0.31850874423980713,
-0.24339567124843597,
0.49094724655151367,
0.3295024037361145,
0.19263306260108948,
-0.6374823451042175,
0.17717844247817993,
0.38160768151283264,
-0.2627893090248108,
0.905205249786377,
-0.10430185496807098,
0.2664085626602173,
0.3009105622768402,
0.1079898327589035,
0.18628248572349548,
0.027043528854846954,
-0.18574939668178558,
-0.4012583792209625,
0.12270570546388626,
0.3950803875923157,
0.30238208174705505,
0.04828108102083206,
-0.11726553738117218,
-0.02075151354074478,
-0.2614325284957886,
0.44223034381866455,
0.17278045415878296,
-0.013664950616657734,
-0.1510099172592163,
0.2055680900812149,
0.05238185077905655,
-0.4417937695980072,
-0.21746250987052917,
-0.02097131870687008,
-0.5263046026229858,
0.3505469262599945,
-0.3737318813800812,
0.28967389464378357,
0.1913154423236847,
-0.2565777897834778,
-0.19394995272159576,
-0.22668783366680145,
-0.2678452432155609,
-0.36683815717697144,
0.3116573393344879,
0.06026192381978035,
0.44470855593681335,
0.2323625534772873,
-0.15793071687221527,
0.11763351410627365,
-0.647153377532959,
-0.29213765263557434,
0.04536495357751846,
-0.509967029094696,
-0.7670055031776428,
-0.14247974753379822,
0.47110864520072937,
0.3171045184135437,
0.15355296432971954,
0.150141179561615,
-0.20479193329811096,
-0.4899737536907196,
0.30180901288986206,
-0.5680737495422363,
0.5056729912757874,
-0.29788538813591003,
-0.11608614772558212,
-0.24034149944782257,
0.15704311430454254,
0.6270856857299805,
0.20211921632289886,
-0.006291606463491917,
0.4807354211807251,
-0.5564826726913452,
0.30892428755760193,
0.09245618432760239,
-0.44774919748306274,
0.13255998492240906,
-0.97540283203125,
-0.06914862990379333,
-0.15927307307720184,
-0.039170484989881516,
-0.36035415530204773,
-0.42841240763664246,
-0.06497733294963837,
0.34092947840690613,
0.4421937167644501,
0.08673281222581863,
0.4905321002006531,
-0.3800990581512451,
0.16380344331264496,
-0.35292014479637146,
-0.0027897837571799755,
-1.2694432735443115,
-0.09096924215555191,
0.25779789686203003,
-0.4661305248737335,
-0.08479107916355133,
-0.21446403861045837,
-0.4471398890018463,
-0.23095624148845673,
0.07154849916696548,
0.2988318204879761,
0.5118947625160217,
-0.3732205331325531,
-0.26451170444488525,
-0.09329558908939362,
-0.3294028043746948,
0.40038633346557617,
-0.04997657239437103,
0.2708854675292969,
0.050250738859176636,
-0.3727479875087738,
0.09128549695014954,
-0.059677742421627045,
-0.1416258066892624,
-0.7129038572311401,
0.19073057174682617,
-0.32813456654548645
] |
Background We aimed to determine the prevalence and gap in use of mental health services for late-life depression in four European regions (Western Europe, Scandinavia, Southern Europe and Central and Eastern Europe) and explore socio-demographic, social and health-related factors associated with it. Methods We conducted a cross-sectional study based on data from the Survey on Health, Ageing and Retirement in Europe. Participants were a population-based sample of 28 796 persons (53% women, mean age 74 years old) residing in Europe. Mental health service use was estimated using information about the diagnosis or treatment for depression. Results The prevalence of late-life depression was 29% in the whole sample and was highest in Southern Europe (35%), followed by Central and Eastern Europe (32%), Western Europe (26%) and lowest in Scandinavia (17%). Factors that had the strongest association with depression were total number of chronic diseases, pain, limitations in instrumental activities of daily living, grip strength and cognitive impairment. The gap in mental health service use was 79%. Conclusions We suggest that interventions to decrease the burden of late-life depression should be targeted at individuals that are affected by chronic somatic comorbidities and are limited in mental and physical functioning. Promotion of help-seeking of older adults, de-stigmatization of mental illness and education of general practitioners could help decrease the gap in mental health service utilization. | [
0.01039950642734766,
0.0028193513862788677,
-0.012907027266919613,
0.013960597105324268,
0.058652304112911224,
-0.01889987662434578,
0.00873560644686222,
0.00894156377762556,
-0.010568175464868546,
0.00820450484752655,
-0.0037694901693612337,
0.011469733901321888,
-0.0128138093277812,
0.021332988515496254,
0.02285734936594963,
0.002668424043804407,
-0.06187216192483902,
0.0040183523669838905,
0.011395261622965336,
-0.005911849904805422,
0.01843811199069023,
-0.016603242605924606,
0.008389107882976532,
0.015077129937708378,
0.022417861968278885,
0.014161985367536545,
0.017515456303954124,
-0.015666110441088676,
0.021909542381763458,
-0.005306876730173826,
-0.00551245454698801,
0.022586733102798462,
-0.005529743619263172,
-0.006706143729388714,
0.0015030312351882458,
0.004294208250939846,
0.006938328500837088,
0.019294125959277153,
-0.032699331641197205,
-0.004416912328451872,
0.02848946861922741,
-0.009770002216100693,
-0.008090521208941936,
0.008428997360169888,
-0.008889775723218918,
0.02494112029671669,
-0.01695067808032036,
0.022224482148885727,
-0.0024932301603257656,
0.014032982289791107,
-0.017682477831840515,
0.010567682795226574,
-0.013563478365540504,
-0.026328222826123238,
-0.0060825045220553875,
0.0017304804641753435,
0.019407127052545547,
0.019700994715094566,
-0.0038808241952210665,
-0.02886912226676941,
-0.016074562445282936,
-0.010234193876385689,
-0.005888254847377539,
0.008026914671063423,
-0.0005561113357543945,
-0.06633802503347397,
-0.025982830673456192,
0.006560234352946281,
0.010888765566051006,
-0.005185271613299847,
-0.015654724091291428,
0.008266824297606945,
0.03226087614893913,
-0.012705378234386444,
0.002974732778966427,
0.025701673701405525,
0.0279257670044899,
0.0003324858844280243,
0.014668240211904049,
-0.03592092543840408,
-0.009157242253422737,
-0.007034988142549992,
-0.019386067986488342,
0.02499314770102501,
-0.02189015783369541,
0.018986869603395462,
-0.021095987409353256,
-0.021743327379226685,
0.006272126454859972,
0.012506993487477303,
0.005435628350824118,
-0.0068164970725774765,
-0.01073947548866272,
-0.009010396897792816,
-0.036651045083999634,
-0.01992735080420971,
-0.0010242494754493237,
0.021113283932209015,
-0.005240398459136486,
-0.00920083001255989,
-0.002172732027247548,
0.002517067827284336,
0.019398339092731476,
0.04086426645517349,
-0.026824481785297394,
0.01353568397462368,
-0.012450327165424824,
0.01258358545601368,
0.0011669814120978117,
-0.0009818613762035966,
-0.014241404831409454,
0.0007276468095369637,
0.0021477588452398777,
0.0015994091518223286,
0.00042714737355709076,
-0.012429382652044296,
-0.00103052519261837,
0.011413276195526123,
-0.0009214510791935027,
-0.03448079153895378,
-0.00979863665997982,
-0.02118796855211258,
-0.009919471107423306,
-0.015085979364812374,
-0.004324797540903091,
0.028469638898968697,
0.003918829374015331,
-0.001894642598927021,
0.004856545478105545,
-0.005922191776335239,
-0.006332320626825094,
0.00405915779992938,
-0.015414450317621231,
-0.00042301230132579803,
0.013805165886878967,
-0.0021577824372798204,
-0.0010601487010717392,
-0.007464616559445858,
-0.01565183512866497,
-0.012172934599220753,
-0.002559331711381674,
0.015734627842903137,
0.001147235045209527,
0.0044658370316028595,
0.010179390199482441,
-0.02336857095360756,
0.017777469009160995,
0.02653391659259796,
0.00275237625464797,
0.01413857564330101,
0.024255048483610153,
-0.014200896956026554,
0.0033545447513461113,
-0.029478155076503754,
-0.023970281705260277,
0.011638267897069454,
-0.018169067800045013,
0.001672406680881977,
0.020629417151212692,
-0.0019890195690095425,
-0.007102181203663349,
-0.016489479690790176,
0.010243838652968407,
0.010078879073262215,
0.019699856638908386,
-0.008101919665932655,
0.006828552111983299,
-0.008624166250228882,
-0.004056816920638084,
0.004414000548422337,
-0.009893535636365414,
0.004137747921049595,
0.028561752289533615,
0.009585205465555191,
-0.01634920760989189,
-0.006835528649389744,
0.03369570150971413,
0.008923035115003586,
0.004912109114229679,
0.06628914177417755,
-0.0533892884850502,
0.014939278364181519,
-0.004893060773611069,
-0.01266912929713726,
0.017754435539245605,
0.0032724179327487946,
0.02593260444700718,
-0.021006112918257713,
0.00053759990260005,
-0.01915481872856617,
-0.019564805552363396,
0.004134605638682842,
0.00965477991849184,
0.009200789034366608,
0.017886579036712646,
0.004840013105422258,
0.021533362567424774,
0.004283105488866568,
-0.018936481326818466,
0.0006599405314773321,
0.01891353540122509,
-0.027232486754655838,
0.016832182183861732,
-0.003207447472959757,
0.0028440672904253006,
0.023132704198360443,
0.03665562719106674,
-0.00280036311596632,
0.017086366191506386,
0.01715744286775589,
0.016246041283011436,
0.00305577483959496,
0.006765441503375769,
0.009534825570881367,
-0.0008630219381302595,
-0.001225524116307497,
-0.02311691641807556,
-0.009509161114692688,
0.01218695193529129,
-0.016730591654777527,
0.0021976102143526077,
-0.003350223880261183,
0.007964463904500008,
0.0005134940147399902,
0.0044571831822395325,
-0.027856647968292236,
0.024466831237077713,
0.0060873208567500114,
0.03841152414679527,
0.005847428925335407,
-0.0017135138623416424,
-0.027514148503541946,
-0.004732068628072739,
0.028452452272176743,
-0.02408607490360737,
0.043956901878118515,
0.009479925967752934,
-0.0007615387439727783,
0.015833819285035133,
-0.017672820016741753,
0.011633574962615967,
-0.036266569048166275,
0.0031652189791202545,
-0.009708959609270096,
-0.0010273512452840805,
-0.02048456482589245,
0.0011710722465068102,
0.0014368153642863035,
-0.03964003175497055,
-0.002501114271581173,
0.0062797293066978455,
-0.031609997153282166,
0.023235255852341652,
0.006380112841725349,
0.03067660704255104,
-0.015949899330735207,
-0.016247887164354324,
-0.02378598228096962,
0.025975780561566353,
-0.0031112805008888245,
0.017518602311611176,
0.011497247032821178,
-0.008080575615167618,
0.0005048203747719526,
-0.001121138222515583,
-0.034794412553310394,
0.01231011375784874,
0.021311365067958832,
0.011032650247216225,
-0.051101066172122955,
0.010484781116247177,
-0.018669063225388527,
0.0020443289540708065,
-0.08166949450969696,
-0.011736256070435047,
0.01503373496234417,
-0.018581734970211983,
0.009408004581928253,
-0.0022070996928960085,
0.027913395315408707,
0.013474652543663979,
0.000145524216350168,
-0.02481181174516678,
-0.003866016399115324,
-0.004182673525065184,
0.0002585522015579045,
-0.04057478532195091,
0.017082611098885536,
-0.012065817601978779,
0.006529562175273895,
0.034480758011341095,
-0.03572889789938927,
0.018411099910736084,
0.00904865376651287,
-0.0034170516300946474,
0.006348656956106424,
0.012973209843039513,
0.004859783686697483,
0.014132929965853691,
0.003642053809016943,
-0.006127877626568079,
-0.007892166264355183,
0.01368001289665699,
-0.04120628535747528,
-0.016425080597400665,
-0.015661027282476425,
-0.0005170917138457298,
-0.007968681864440441,
0.02575775980949402,
-0.045688118785619736,
0.02037661522626877,
0.004969906993210316,
0.01291615515947342,
0.01496643666177988,
0.005433785729110241,
0.02927907183766365,
-0.028487686067819595,
0.006832124665379524,
-0.01069234311580658,
0.0008227753569371998,
-0.03023458831012249,
0.011475799605250359,
-0.017235642299056053,
0.013298138976097107,
-0.0074209049344062805,
0.0027015572413802147,
0.0013665384612977505,
-0.02481287345290184,
-0.028633590787649155,
-0.015384413301944733,
-0.004436979070305824,
-0.01169584784656763,
-0.0065676551312208176,
-0.011335075832903385,
-0.017709912732243538,
0.017321858555078506,
-0.014934409409761429,
0.02658424898982048,
-0.008071506395936012,
-0.0002293693833053112,
0.01055095624178648,
-0.009816094301640987,
0.011443104594945908,
0.01105677243322134,
-0.026149891316890717,
0.018616918474435806,
-0.0038634592201560736,
0.002594267949461937,
-0.004231145605444908,
-0.01644546538591385,
0.007718396373093128,
0.010811755433678627,
0.010906546376645565,
0.00401669554412365,
-0.015795227140188217,
-0.01835155487060547,
-0.015591098926961422,
0.0006596592720597982,
0.008897303603589535,
0.01831388846039772,
0.029814936220645905,
0.004381438251584768,
-0.01714775338768959,
-0.022632762789726257,
-0.004462263081222773,
0.01981797069311142,
0.006301728542894125,
-0.006177796050906181,
-0.027493048459291458,
0.027613114565610886,
-0.015124037861824036,
-0.024325616657733917,
0.00830849353224039,
0.01567668654024601,
0.0022685802541673183,
-0.009706558659672737,
-0.01895507052540779,
0.014707736670970917,
0.014572471380233765,
-0.004389917012304068,
-0.0004057306796312332,
-0.011549457907676697,
-0.007229757495224476,
-0.0005184070323593915,
-0.03523673117160797,
-0.010203849524259567,
0.029366914182901382,
0.015527734532952309,
-0.0008379030041396618,
0.006750571541488171,
0.000009922077879309654,
0.07189691066741943,
0.018023472279310226,
0.024994786828756332,
-0.021283317357301712,
-0.007922040298581123,
0.000613151234574616,
-0.007795208133757114,
-0.011912144720554352,
0.013231870718300343,
-0.02100358158349991,
0.013155121356248856,
0.03240285441279411,
0.011017236858606339,
-0.014827226288616657,
0.013142438605427742,
0.01243251096457243,
-0.00680703017860651,
-0.007336991839110851,
-0.011805723421275616,
0.0000013476237654685974,
0.01720765233039856,
0.017221037298440933,
-0.010614123195409775,
0.005677782464772463,
0.013810830190777779,
-0.017567753791809082,
-0.02750847116112709,
-0.009117281064391136,
0.0006299120141193271,
0.0023408979177474976,
-0.016304785385727882,
0.047746848315000534,
-0.004956918768584728,
0.0025221901014447212,
0.00994262658059597,
0.0036743013188242912,
-0.02852422371506691,
-0.01772363856434822,
0.00803547352552414,
0.001846939092501998,
0.02851897105574608,
-0.008454076945781708,
0.0006021410226821899,
0.0031739044934511185,
-0.03378353267908096,
0.009716479107737541,
0.01846952922642231,
-0.008505566045641899,
-0.004594695288687944,
0.029372140765190125,
0.003703046590089798,
0.012894412502646446,
0.017594410106539726,
-0.005948095582425594,
0.007825850509107113,
0.010758254677057266,
0.002837871666997671,
0.003661432769149542,
-0.0015272023156285286,
0.009241592139005661,
0.01346118375658989,
0.0033637909218668938,
0.007949123159050941,
-0.03361808881163597,
-0.013803219422698021,
-0.018204595893621445,
0.0021986295469105244,
0.0034817829728126526,
-0.005772026721388102,
0.007128167897462845,
0.024889115244150162,
-0.005161288194358349,
-0.010318631306290627,
0.001881470438092947,
-0.003277173498645425,
-0.019728196784853935,
-0.0050059095956385136,
-0.009413832798600197,
0.008825192227959633,
0.0041089910082519054,
-0.012407141737639904,
0.021266119554638863,
0.009701604954898357,
-0.011913888156414032,
0.017652153968811035,
-0.016441654413938522,
-0.025069596245884895,
-0.07424288988113403,
-0.021420126780867577,
0.014878218062222004,
-0.012897927314043045,
-0.021173637360334396,
0.0009194964077323675,
-0.017517881467938423,
-0.0005034825298935175,
0.00040712207555770874,
-0.01323698926717043,
0.00046309689059853554,
-0.0032742503099143505,
-0.005572246387600899,
0.0029626355972141027,
0.013922654092311859,
-0.02565402165055275,
0.021298209205269814,
0.004377874080091715,
-0.00399151723831892,
0.024974053725600243,
0.024800507351756096,
0.023629944771528244,
-0.0014232443645596504,
-0.00918478425592184,
0.010528629645705223,
-0.08066490292549133,
0.02162874862551689,
-0.020490556955337524,
-0.00009811297059059143,
-0.0161589365452528,
-0.005115929991006851,
0.027286255732178688,
-0.0008700729813426733,
-0.013522094115614891,
-0.014604104682803154,
-0.011022798717021942,
-0.007168623618781567,
0.007429420482367277,
-0.01183654647320509,
-0.01804293505847454,
-0.000595355755649507,
0.01852921023964882,
0.00007804203778505325,
-0.022890545427799225,
0.01820831559598446,
-0.010703136213123798,
0.014297311194241047,
0.002107013249769807,
0.04245524853467941,
0.0024265723768621683,
-0.04377606511116028,
0.0021271214354783297,
0.005581456236541271,
0.006594137754291296,
-0.026796013116836548,
0.019510440528392792,
0.013152481988072395,
-0.009919632226228714,
-0.023319484665989876,
-0.015378525480628014,
-0.017147023230791092,
0.02489502541720867,
-0.01813136227428913,
-0.01699221134185791,
0.0034140641801059246,
-0.011007178574800491,
0.017464112490415573,
0.047891344875097275,
-0.012872086837887764,
0.009882482700049877,
-0.000039206817746162415,
0.010210305452346802,
-0.0023159137926995754,
0.01298394426703453,
-0.03452043980360031,
0.009676404297351837,
-0.010149916633963585,
-0.022137658670544624,
0.013145262375473976,
0.005835209507495165,
-0.015411661006510258,
-0.014774113893508911,
0.008992550894618034,
0.03950943052768707,
0.012138843536376953,
-0.0011970640625804663,
-0.010588271543383598,
-0.01601490192115307,
0.0713438019156456,
-0.015957843512296677,
0.015709877014160156,
0.012679931707680225,
0.002736007794737816,
-0.0021505733020603657,
0.02103719487786293,
-0.03846282884478569,
-0.004007428884506226,
0.027280882000923157,
-0.030195778235793114,
-0.001038354355841875,
0.004336285404860973,
0.015622435137629509,
0.0185724925249815,
-0.033276937901973724,
-0.026416804641485214,
0.02031705714762211,
-0.03223622590303421,
-0.012930568307638168,
0.06127459928393364,
0.0033383683767169714,
-0.013969037681818008,
0.0023513869382441044,
0.02225251868367195,
-0.007490402553230524,
0.0443972572684288,
0.00656396197155118,
0.011541442945599556,
0.0074045900255441666,
-0.017063923180103302,
-0.023821502923965454,
0.01122097298502922,
-0.008024722337722778,
0.015591377392411232,
-0.011346587911248207,
0.029792271554470062,
0.008983340114355087,
0.008721473626792431,
0.021964624524116516,
-0.010045738890767097,
-0.039076097309589386,
0.01942799612879753,
-0.007307227700948715,
0.023774893954396248,
0.00012142956256866455,
0.005281421355903149,
-0.008961704559624195,
-0.0007147337310016155,
0.015968551859259605,
-0.003137508174404502,
0.009147471748292446,
-0.00024424027651548386,
-0.01336588989943266,
0.0050462158396840096,
0.00043369783088564873,
0.0005616166163235903,
0.020234178751707077,
0.003339187940582633,
-0.025945570319890976,
0.022801002487540245,
-0.006149032153189182,
0.009350472129881382,
-0.008982083760201931,
0.007852056995034218,
0.020653136074543,
0.012983274646103382,
-0.00024280440993607044,
0.0024977843277156353,
0.009545257315039635,
-0.01955936849117279,
0.0012984699569642544,
0.011148247867822647,
-0.01266744639724493,
-0.012104103341698647,
0.016125820577144623,
-0.010793046094477177,
-0.04216845706105232,
0.0065356963314116,
0.0034051877446472645,
-0.0070610675029456615,
-0.0011594619136303663,
-0.00987129844725132,
-0.011518731713294983,
0.0075638205744326115,
0.01492946594953537,
-0.014989757910370827,
0.031119748950004578,
-0.014118637889623642,
0.00047794211423024535,
0.00021825009025633335,
0.019185323268175125,
0.0017076351214200258,
0.022788142785429955,
0.013859371654689312,
0.035550788044929504,
-0.003636631416156888,
0.013584993779659271,
-0.00008506514132022858,
-0.007197530008852482,
-0.006597336381673813,
0.037039320915937424,
0.01992838643491268,
-0.002377198077738285,
-0.003232343355193734,
-0.014364298433065414,
-0.011567818000912666,
0.020169463008642197,
0.0034161373041570187,
-0.002155708149075508,
-0.027434734627604485,
0.013063449412584305,
0.027729246765375137,
-0.006042499095201492,
0.004648205358535051,
0.023940961807966232,
-0.0006986409425735474,
-0.028147488832473755,
0.00019470509141683578,
-0.021029742434620857,
0.02567501738667488,
-0.018242469057440758,
0.004700519610196352,
0.01757478341460228,
0.01007760688662529,
-0.007616235874593258,
-0.00015988457016646862,
0.0553467683494091,
0.01649828441441059,
0.00009671691805124283,
0.017153408378362656,
0.02191889099776745,
-0.017549389973282814,
-0.019343886524438858,
-0.0034386201296001673,
-0.023946058005094528,
0.006678341887891293,
0.0004778541624546051,
-0.010374982841312885,
-0.007323342841118574,
0.02047157660126686,
-0.013022984378039837,
0.007057860493659973,
-0.00922589935362339,
0.010325580835342407,
-0.0054369280114769936,
-0.02245134674012661,
0.021489957347512245,
0.017519459128379822,
-0.0182957760989666,
-0.004016055725514889,
0.013221478089690208,
0.010943884029984474,
-0.0021051443181931973,
-0.0031770337373018265,
0.010171066969633102,
0.0033857631497085094,
0.0230714064091444,
0.00714994128793478,
-0.011288446374237537,
-0.010043710470199585,
-0.0012422669678926468,
0.016855385154485703,
0.011440195143222809,
-0.004330050200223923,
0.0021004904992878437,
0.014885645359754562,
0.008359136059880257,
-0.002026153262704611,
0.023170078173279762,
-0.022633332759141922,
-0.01007823646068573,
0.00759145338088274,
0.00703301839530468,
-0.043152108788490295,
0.010295575484633446,
0.0006419236306101084,
0.01605188101530075,
-0.008341368287801743,
0.01885594055056572,
-0.0006954597774893045,
0.009318128228187561,
-0.011021288111805916,
-0.016366800293326378,
-0.004926096182316542,
0.028337832540273666,
-0.00009965314529836178,
-0.006389626767486334,
0.006396688055247068,
0.0036873845383524895,
-0.014551152475178242,
-0.012380331754684448,
-0.020959695801138878,
-0.0059280553832650185,
0.004625651985406876,
0.010750719346106052,
-0.006812832318246365,
0.020559951663017273,
-0.004593438934534788,
-0.002629782073199749,
0.01974572241306305,
-0.03179796412587166
] | [
0.485511839389801,
-0.32453227043151855,
0.1369006484746933,
0.15276437997817993,
0.10901681333780289,
1.0837998390197754,
0.4722021520137787,
0.10535307228565216,
-0.48465409874916077,
-0.33373337984085083,
0.12616921961307526,
0.35390976071357727,
0.333185076713562,
0.06885036081075668,
-0.337735116481781,
0.6099965572357178,
0.6244686841964722,
0.05865087732672691,
-0.31850895285606384,
-0.5836695432662964,
-0.22189050912857056,
-0.05260874330997467,
0.6463541388511658,
0.0519622266292572,
-0.0965505838394165,
0.1016443595290184,
0.525809645652771,
-0.029699750244617462,
0.07636097818613052,
-0.13246233761310577,
-0.38568174839019775,
0.6502618193626404,
-0.08460404723882675,
-0.11181993782520294,
0.24774885177612305,
0.004876814782619476,
0.33479124307632446,
0.059572864323854446,
0.1423032581806183,
-0.050047073513269424,
-0.2421642541885376,
-0.08448714762926102,
-0.04129767417907715,
0.49140098690986633,
-0.46672722697257996,
-0.34745627641677856,
-1.093118667602539,
0.5038695335388184,
-0.18454544246196747,
-0.20114554464817047,
0.057364992797374725,
0.48862311244010925,
0.6782296895980835,
0.46172335743904114,
0.02202681265771389,
-0.06606721878051758,
-0.2320176661014557,
-0.2609100639820099,
0.2536584138870239,
-0.4335409104824066,
0.05023731291294098,
0.12645208835601807,
0.12896233797073364,
-0.1891811490058899,
0.02863958850502968,
0.16863790154457092,
0.22864268720149994,
0.12154322117567062,
0.13528481125831604,
-0.13505934178829193,
-0.20090268552303314,
-0.268839031457901,
-0.2389380931854248,
0.022336114197969437,
-0.29704737663269043,
0.3578874468803406,
0.21018093824386597,
-0.055304355919361115,
0.30098292231559753,
-0.3591556251049042,
0.10128463804721832,
-0.4632687270641327,
0.6024788618087769,
-0.4173179268836975,
0.536839485168457,
0.1971336305141449,
0.1024591475725174,
0.19046637415885925,
-0.05106250196695328,
-0.1603417843580246,
-0.44580724835395813,
-0.25881507992744446,
0.6090042591094971,
1.0819730758666992,
-0.02003014087677002,
0.5866771340370178,
0.22434668242931366,
-0.1274128556251526,
0.43252164125442505,
0.22505366802215576,
-0.013471200130879879,
0.33668845891952515,
-0.007016465999186039,
-0.2410225123167038,
-0.30901461839675903,
-0.3928382098674774,
0.159162700176239,
-0.09326982498168945,
-0.8128612041473389,
0.07715253531932831,
-0.8413435816764832,
0.11730398237705231,
-0.03369884192943573,
-0.1472959816455841,
-0.0421924963593483,
-0.0528910793364048,
-0.07564250379800797,
-0.49500882625579834,
-0.13413386046886444,
0.4058174192905426,
-0.21520011126995087,
0.5276240706443787,
-0.290075421333313,
0.14103810489177704,
0.11530281603336334,
0.44832417368888855,
0.5568075180053711,
0.28935933113098145,
-0.12610884010791779,
0.2983863949775696,
0.5819562077522278,
0.3694610893726349,
-0.6586587429046631,
0.250274658203125,
-0.0890386626124382,
-0.3663758635520935,
0.3294192850589752,
0.591995358467102,
0.3020276129245758,
0.28243908286094666,
-0.4152211844921112,
-0.4339101016521454,
-0.23299568891525269,
-0.06552015244960785,
0.3910607695579529,
-0.6148048043251038,
0.05539863929152489,
-0.2589452862739563,
-0.16533491015434265,
-0.13230974972248077,
0.28588712215423584,
-0.0846000537276268,
-0.1856689751148224,
-0.44612404704093933,
-0.2711186110973358,
0.2578102648258209,
-0.26152071356773376,
-0.13495858013629913,
-0.3190345764160156,
-0.012202412821352482,
0.4802243411540985,
0.4655238091945648,
-0.22247610986232758,
0.3297218680381775,
0.7803378701210022,
-0.1340252310037613,
-0.05178282782435417,
-0.38831034302711487,
-0.1348973661661148,
0.7775973677635193,
-0.41000545024871826,
0.1460135579109192,
-0.15551036596298218,
-0.7780176997184753,
-0.12339965999126434,
0.41786330938339233,
0.29022470116615295,
0.06645378470420837,
0.18014608323574066,
-0.19455158710479736,
-0.5143581628799438,
0.0031417692080140114,
0.21009711921215057,
-0.4055905342102051,
0.005351528991013765,
-0.03649947792291641,
0.13555262982845306,
-0.006988141685724258,
-0.04522809386253357,
-0.24293974041938782,
-0.3032178580760956,
-0.41361337900161743,
0.9432166814804077,
-0.7272464036941528,
1.1385923624038696,
-0.8038314580917358,
-0.048665858805179596,
1.1578419208526611,
0.09128469973802567,
0.020046047866344452,
0.26797640323638916,
-0.5382681488990784,
0.4975573718547821,
0.05145423859357834,
-0.41482239961624146,
0.03200286254286766,
-0.13510039448738098,
-0.0988973006606102,
-0.004204025492072105,
-0.03693866729736328,
0.25362345576286316,
-0.39948686957359314,
-0.44930657744407654,
-0.015489046461880207,
-0.23925364017486572,
0.25527575612068176,
-0.1849633902311325,
0.28526046872138977,
0.32704707980155945,
0.11499983072280884,
0.4958905577659607,
-0.5241103172302246,
0.24595797061920166,
-0.1870095133781433,
-0.18651071190834045,
0.24536146223545074,
0.25329747796058655,
-0.2825700044631958,
0.6377183794975281,
-0.6872962713241577,
0.10999061912298203,
0.41812989115715027,
0.0032526475843042135,
-0.4121566116809845,
-0.12061931937932968,
0.13997556269168854,
-0.17040447890758514,
0.17638303339481354,
-0.08406735956668854,
-0.10462188720703125,
-0.13738876581192017,
0.3262811005115509,
-0.5207775235176086,
-0.0910695344209671,
-0.05451013892889023,
-0.27749764919281006,
-0.4569763243198395,
0.5011894702911377,
-0.7461790442466736,
-0.12430398911237717,
0.08645584434270859,
0.2820110619068146,
-0.14951328933238983,
-0.47381699085235596,
-0.46246492862701416,
0.11177101731300354,
-0.06134135648608208,
-0.4390122890472412,
0.6112638711929321,
-0.3170025944709778,
-0.09382158517837524,
0.21962040662765503,
0.3117337226867676,
0.08667405694723129,
0.4948388338088989,
-0.6434199810028076,
-0.7608034014701843,
-0.8472756147384644,
0.7876241207122803,
0.3264009654521942,
0.5939566493034363,
0.03399065509438515,
-0.28680962324142456,
0.23129282891750336,
-0.011665534228086472,
-0.5005704164505005,
-0.044377390295267105,
0.47682151198387146,
-0.7898055911064148,
-0.7391275763511658,
-0.07280346006155014,
0.23009592294692993,
0.6933894157409668,
0.11842674016952515,
0.021021643653512,
-0.1419907659292221,
0.041742030531167984,
0.07620324939489365,
-0.0952058807015419,
0.2411111742258072,
0.129132479429245,
0.46625053882598877,
-0.04999733343720436,
-0.394369512796402,
0.5367985963821411,
0.69415682554245,
-0.37974733114242554,
0.8040714859962463,
0.6819700598716736,
-0.07896335422992706,
0.1544041931629181,
0.4952127933502197,
0.013600111939013004,
-0.09580076485872269,
-0.000299368315609172,
0.01057716365903616,
-0.496329665184021,
-0.1574592888355255,
-5.897331714630127,
0.34066131711006165,
-0.5303205847740173,
-0.2799220085144043,
-0.23525555431842804,
0.3064630925655365,
1.0123283863067627,
0.1677244007587433,
0.12366804480552673,
-0.08297067135572433,
0.03832075372338295,
0.2631079852581024,
0.20928794145584106,
0.7671892642974854,
0.2277166098356247,
0.21942926943302155,
0.3899970054626465,
-0.34693869948387146,
0.6091858744621277,
0.23603960871696472,
-0.0030366096179932356,
-0.3899194598197937,
-0.09048506617546082,
0.38399434089660645,
0.5445011258125305,
0.24847397208213806,
-0.7567164301872253,
0.0906110405921936,
-0.10534180700778961,
-0.3183789551258087,
0.30881425738334656,
-1.0029019117355347,
-0.2520298361778259,
-0.002684163860976696,
0.6989613771438599,
0.11888560652732849,
0.4957585036754608,
0.13095739483833313,
0.26153096556663513,
-0.4673531651496887,
-0.14922675490379333,
0.6223843097686768,
-0.11692948639392853,
0.0527351051568985,
0.2548767924308777,
0.44104838371276855,
-0.011668181046843529,
-0.12322842329740524,
-0.2861679196357727,
0.9132031798362732,
0.1394433230161667,
0.19199778139591217,
-0.11610999703407288,
0.1952424794435501,
0.12637409567832947,
0.08710287511348724,
-0.10007014870643616,
0.5549356937408447,
-0.23683656752109528,
0.5123037695884705,
0.19454792141914368,
0.2606208324432373,
0.27670544385910034,
-0.9297814965248108,
-0.3734827935695648,
0.0863988846540451,
-1.253285527229309,
-0.26688337326049805,
0.048121072351932526,
-0.11396670341491699,
-0.0493907667696476,
-0.35638973116874695,
0.14205852150917053,
-0.634375810623169,
0.25025734305381775,
-0.38054358959198,
0.03753691166639328,
0.07421613484621048,
0.14003773033618927,
-0.37440022826194763,
0.2971835434436798,
0.03313863277435303,
0.45854702591896057,
-0.18786074221134186,
0.1606263816356659,
0.4938739240169525,
-0.05958178639411926,
-0.25563734769821167,
-0.41519659757614136,
-0.00722915306687355,
0.43524837493896484,
-0.721390426158905,
-0.1408834010362625,
0.22772960364818573,
0.38862165808677673,
1.0725536346435547,
0.2619096040725708,
0.01553426031023264,
0.2618783116340637,
-0.13805553317070007,
0.4988245964050293,
-0.3025568425655365,
-0.45166948437690735,
-0.8647258877754211,
-0.14764943718910217,
-0.04381449520587921,
-0.5173666477203369,
0.30762219429016113,
0.7900590300559998,
-0.7788174748420715,
0.4813089370727539,
0.06021994724869728,
-0.3614118993282318,
-0.43673890829086304,
0.5575770139694214,
-0.2534117102622986,
-0.33423885703086853,
-0.2207868993282318,
0.4427259564399719,
-0.16443444788455963,
0.09825804829597473,
-0.018480176106095314,
-0.27599257230758667,
0.43527019023895264,
-0.2079475373029709,
-0.6117754578590393,
0.03359752148389816,
0.24784992635250092,
-1.0024079084396362,
0.38590532541275024,
-0.2708989679813385,
0.4332215189933777,
-0.24545107781887054,
-0.04376997426152229,
0.2235672026872635,
-0.18917694687843323,
-0.2028404176235199,
-0.1546413004398346,
0.4483744204044342,
0.19613467156887054,
-0.052505966275930405,
-0.23958924412727356,
0.06213222071528435,
0.2948811948299408,
0.7660105228424072,
-0.2865630090236664,
-0.47985899448394775,
-0.27130308747291565,
-0.20966409146785736,
0.00039596130955033004,
0.1531245857477188,
0.33704227209091187,
0.3413430154323578,
0.0017199523281306028,
-0.5359165072441101,
-0.15477165579795837,
0.43610748648643494,
0.031419266015291214,
-0.3287673890590668,
-0.4764864146709442,
0.6206982731819153,
-0.2746833860874176,
-1.1388741731643677,
-0.012352799996733665,
0.3806450068950653,
-0.5922309160232544,
-0.08524329215288162,
-0.5164494514465332,
0.41274863481521606,
0.37721124291419983,
0.22708001732826233,
-0.360292911529541,
0.17250700294971466,
-0.1873406022787094,
0.23548509180545807,
-0.3673822581768036,
-0.36997827887535095,
0.27565693855285645,
-0.40634843707084656,
0.11988887935876846,
0.06710677593946457,
0.2140665203332901,
-0.6292626261711121,
0.12162632495164871,
0.8225057125091553,
1.0063691139221191,
-0.18488749861717224,
0.2084060162305832,
-0.3081619441509247,
-0.610960066318512,
0.26926466822624207,
-0.18306593596935272,
0.4888610243797302,
0.1255216747522354,
-0.17866754531860352,
-0.23024524748325348,
0.2838691473007202,
0.5976418256759644,
-0.31039509177207947,
0.17894166707992554,
-0.20383967459201813,
0.24832110106945038,
-0.1854005753993988,
0.535686731338501,
0.4791150689125061,
-0.23923078179359436,
0.0883348286151886,
-0.4074782431125641,
-0.46577179431915283,
-0.23543906211853027,
-0.43651315569877625,
-0.127898171544075,
-0.821188747882843,
0.47473910450935364,
-0.6314850449562073,
-0.021738894283771515,
0.015127676539123058,
-0.5425499677658081,
-0.36750608682632446,
0.30279210209846497,
0.5010865330696106,
-0.15182314813137054,
-0.3059942424297333,
0.0005277357995510101,
-0.15262393653392792,
-0.03464816138148308,
0.7926682233810425,
-0.650870144367218,
-0.41232070326805115,
0.2814911901950836,
-0.6182953715324402,
0.13659285008907318,
0.4069863557815552,
-0.21753190457820892,
-0.7448553442955017,
0.09716582298278809,
-0.07860253006219864,
-0.19894355535507202,
0.30293720960617065,
0.6481215357780457,
0.11781606823205948,
0.4197709262371063,
0.087861567735672,
-0.9106106162071228,
0.2651034891605377,
0.22984053194522858,
0.5732505917549133,
-0.6084510684013367,
-0.17330095171928406,
0.012132568284869194,
0.18758150935173035,
-0.542756199836731,
-0.10069148987531662,
-0.3001985251903534,
0.13627387583255768,
-0.13326451182365417,
-0.5365965962409973,
-0.616837739944458,
0.167148157954216,
0.41149792075157166,
-0.2089490443468094,
-1.1147124767303467,
0.2682775557041168,
-0.15239964425563812,
0.28960365056991577,
-0.0031680080574005842,
-0.011246082372963428,
-0.0197459664195776,
-0.07145664840936661,
-0.571855902671814,
0.18841221928596497,
0.11065933853387833,
0.19143259525299072,
0.013620151206851006,
0.1994156837463379,
-0.03203152120113373,
-0.3628996014595032,
0.10011421144008636,
-0.07282783091068268,
0.001000958145596087,
-0.752703070640564,
-0.7385997772216797,
-0.0374482162296772,
-0.22366651892662048,
0.02269229106605053,
-0.3855733871459961,
0.3157155215740204,
-0.15775051712989807,
-0.5635333061218262,
-0.37798118591308594,
-0.058515191078186035,
-0.3534506559371948,
-0.3285263478755951,
-0.03747711330652237,
-0.023242399096488953,
0.10769681632518768,
0.1505308747291565,
0.41614970564842224,
0.4888255298137665,
0.003957896959036589,
-0.14261271059513092,
0.4685475528240204,
-0.1644388735294342,
-0.38103121519088745,
0.40301188826560974,
-0.012203481048345566,
0.2626519501209259,
-0.24228152632713318,
0.17376728355884552,
0.09524710476398468,
0.48199206590652466,
-0.019099507480859756,
0.4441838562488556,
0.4026775062084198,
-0.3510315716266632,
-0.019033780321478844,
-0.30483394861221313,
-0.6855698823928833,
0.6361756920814514,
0.18220318853855133,
0.2246924787759781,
0.8065221309661865,
0.8482123613357544,
-0.03618311882019043,
0.10944517701864243,
0.8520101308822632,
-0.19630202651023865,
0.5267805457115173,
-0.07775528728961945,
-0.2630065977573395,
0.3938812017440796,
0.844645082950592,
-0.11292829364538193,
0.30041635036468506,
0.132978618144989,
0.2688465714454651,
-0.07769384235143661,
-0.5706484913825989,
0.06950723379850388,
-0.021563299000263214,
0.878484308719635,
0.45509010553359985,
0.22475197911262512,
-0.3108600080013275,
0.31923171877861023,
0.41229936480522156,
-0.11113489419221878,
0.058014195412397385,
0.43879249691963196,
0.3740181028842926,
0.23876304924488068,
-0.5390770435333252,
-0.13631880283355713,
-0.15439696609973907,
0.03754456713795662,
0.5188808441162109,
-0.11446036398410797,
-0.11811614781618118,
-1.131105899810791,
0.13863836228847504,
0.40277642011642456,
-0.058483999222517014,
-0.2245008796453476,
0.041933443397283554,
-0.42985767126083374,
-0.16103579103946686,
0.05709950625896454,
0.28564515709877014,
0.14338399469852448,
-0.45890629291534424,
0.15234306454658508,
-0.11967937648296356,
-0.2712920904159546,
-0.07087916880846024,
0.016238469630479813,
-0.7471304535865784,
0.42115554213523865,
-0.19263848662376404,
0.2856757938861847,
0.4422946274280548,
-0.29140686988830566,
0.16059298813343048,
0.06429999321699142,
-0.06920287758111954,
-0.019147973507642746,
-0.3783576190471649,
0.01753150299191475,
-0.05728689953684807,
0.1966153383255005,
0.11280491948127747,
-0.00837080180644989,
-0.2882871925830841,
0.21128137409687042,
0.2933407723903656,
-0.41439661383628845,
-0.22192738950252533,
-0.18071670830249786,
0.43908414244651794,
0.35402488708496094,
0.07245206087827682,
-0.19026577472686768,
-0.1319981813430786,
-0.3246837556362152,
0.409561425447464,
0.019620884209871292,
0.30002400279045105,
-0.7111737132072449,
-0.5414898991584778,
-0.35758936405181885,
0.03967282548546791,
0.6276461482048035,
-0.05908502638339996,
-0.39206990599632263,
0.140750452876091,
-0.01154694240540266,
0.3720620572566986,
0.5508468151092529,
0.1502712070941925,
-0.34043043851852417,
-0.3891519010066986,
-0.023268407210707664,
-0.7684000730514526,
0.6213206052780151,
-0.6563465595245361,
-0.07559483498334885,
-0.11994242668151855,
0.2614688277244568,
0.5521056056022644,
-0.036861274391412735,
0.3898722231388092,
-0.3821878433227539,
-0.6469516158103943,
-0.5435127019882202,
0.7993968725204468,
-0.6238630414009094,
0.680774450302124,
0.38424888253211975,
-0.07233896106481552,
0.33054569363594055,
-0.37989380955696106,
-0.378478080034256,
-0.6776069402694702,
0.3306770622730255,
0.0731625035405159,
-0.09710193425416946,
0.4373208284378052,
-0.05268232896924019,
-0.22945597767829895,
-0.7283889651298523,
0.0869227796792984,
-0.6334179043769836,
-0.7143813967704773,
0.023563990369439125,
-0.07650697976350784,
-0.4273437559604645,
-0.41061651706695557,
-0.1598130315542221,
-0.8110555410385132,
-0.23899048566818237,
-0.7399811744689941
] |
An Al/methyl-red/p-InP solar cell was fabricated via solution-processing method and was characterized by using current-voltage (I-V) and capacitance-voltage-frequency (C-V-f) measurements at room temperature. From dark I-V characteristics, the values of ideality factor and barrier height of the device were calculated as 1.11 eV and 2.02, respectively. It has been seen that the device exhibited a good photovoltaic behavior with a maximum open circuit voltage of 0.38 V and short-circuit current of 2.8 nA under only 200 lx light intensity. The barrier height and acceptor carrier concentration values for the Al/methyl-red/p-InP devices were extracted as 1.27 eV and from linear region of its characteristics, respectively. The difference between (I-V) and (C-V) for Al/methyl-red/p-InP device was attributed the different nature of the I-V and C-V measurements. Also, the energy distribution curves of the interface states and their time constants were obtained from the experimental conductance properties of the Al/methyl-red/p-InP structure at room temperature. The interface state densities and their relaxation times of the device have ranged from and s at (1.11-) eV to and s at (0.79-) eV, respectively. It was seen that both the interface state density and the relaxation time of the interface states have decreased with bias voltage from experimental results. | [
0.001327544217929244,
0.001991133438423276,
-0.019022276625037193,
-0.0024758134968578815,
-0.026283834129571915,
-0.010965632274746895,
0.009985188953578472,
-0.018810784444212914,
-0.009997602552175522,
0.013886290602385998,
-0.010107657872140408,
0.02075100503861904,
-0.009985147975385189,
0.023402057588100433,
0.026825902983546257,
0.016559066250920296,
-0.011761867441236973,
-0.00063184997998178,
0.012164183892309666,
-0.013693585991859436,
-0.012543841265141964,
-0.026791922748088837,
0.01063032727688551,
-0.035926155745983124,
-0.02804606221616268,
-0.012973150238394737,
0.031116362661123276,
-0.012993838638067245,
-0.024765409529209137,
-0.013750732876360416,
0.022157061845064163,
-0.022960569709539413,
0.02697761356830597,
-0.008129632100462914,
0.007219456601887941,
-0.013425804674625397,
-0.0025164159014821053,
0.020193837583065033,
0.03700287640094757,
-0.0043566725216805935,
-0.04730281978845596,
-0.005177376791834831,
0.010622464120388031,
0.008244368247687817,
-0.006957455072551966,
0.008888773620128632,
-0.0062531232833862305,
-0.00609111413359642,
0.005441248882561922,
0.006698626093566418,
-0.01662321388721466,
-0.012300663627684116,
-0.011741907335817814,
-0.0032706432975828648,
-0.007353718858212233,
-0.044756270945072174,
0.01832169108092785,
0.02217295952141285,
0.015499768778681755,
0.004855578299611807,
-0.032563868910074234,
-0.03245673328638077,
-0.004035663325339556,
-0.037526052445173264,
0.010382764041423798,
-0.06618843972682953,
-0.019441982731223106,
0.021821392700076103,
0.006803690455853939,
-0.04174799472093582,
-0.02309410087764263,
0.01045621745288372,
-0.0026649730280041695,
0.006409305613487959,
-0.0056984503753483295,
-0.012887468561530113,
-0.020919639617204666,
0.02532561495900154,
-0.00409789988771081,
-0.022404666990041733,
-0.010487204417586327,
-0.021126702427864075,
0.009224340319633484,
0.018168333917856216,
-0.027240369468927383,
-0.004187997430562973,
-0.006818227469921112,
-0.002616909332573414,
-0.013674065470695496,
0.011213071644306183,
-0.0019431090913712978,
-0.010546300560235977,
0.0009690262377262115,
-0.035056933760643005,
0.002573215402662754,
0.02261059358716011,
0.0016333418898284435,
-0.03058544360101223,
-0.015834990888834,
-0.013726133853197098,
-0.003993299324065447,
-0.027405384927988052,
0.012283919379115105,
-0.022234419360756874,
-0.0054668341763317585,
0.007242904976010323,
0.005692052189260721,
-0.02110620215535164,
0.011087292805314064,
0.007980809547007084,
-0.01054278016090393,
0.014461456798017025,
0.006543265655636787,
0.006026944611221552,
-0.005209086462855339,
-0.006378352642059326,
-0.007807942107319832,
0.018725356087088585,
0.006281081587076187,
0.02398146502673626,
-0.035499438643455505,
-0.014023229479789734,
-0.00022529973648488522,
0.02589304745197296,
0.01313529722392559,
0.011926496401429176,
0.005983311682939529,
-0.005835020914673805,
0.010660568252205849,
0.0007269119378179312,
-0.007864348590373993,
0.014973306097090244,
0.01655443198978901,
-0.006854758597910404,
-0.006361896637827158,
-0.003336054738610983,
0.02262887731194496,
-0.009107963182032108,
-0.00360170379281044,
-0.012307613156735897,
-0.01303967647254467,
0.008707863278687,
0.00031479564495384693,
0.027488522231578827,
0.03497838228940964,
-0.019055945798754692,
-0.0027206488884985447,
-0.00783882662653923,
-0.011164132505655289,
-0.010864770971238613,
0.0010710826609283686,
-0.02900441735982895,
-0.019674554467201233,
-0.012523571029305458,
0.04337013512849808,
0.010098332539200783,
-0.030245887115597725,
0.011072617024183273,
-0.011460238136351109,
-0.015105200931429863,
-0.017903050407767296,
0.02718258649110794,
0.027882415801286697,
0.011366590857505798,
0.0023283043410629034,
0.03080785647034645,
-0.010663483291864395,
-0.014046618714928627,
-0.01661311835050583,
0.006942565552890301,
-0.004839172586798668,
0.008541426621377468,
0.0078047714196145535,
0.011664766818284988,
0.014882766641676426,
0.006002409383654594,
-0.020801912993192673,
0.006095142103731632,
-0.013759604655206203,
0.06632648408412933,
0.021389631554484367,
-0.005301686003804207,
0.04060062766075134,
-0.03185698017477989,
0.018215032294392586,
-0.03353562951087952,
-0.030317138880491257,
-0.010962136089801788,
-0.013785433024168015,
-0.008768562227487564,
-0.002453216351568699,
-0.01775268465280533,
-0.008796550333499908,
-0.00241271173581481,
-0.021448597311973572,
0.004657618701457977,
0.008688608184456825,
0.0063593387603759766,
0.012185327708721161,
-0.01878928765654564,
0.01695617474615574,
-0.003049270249903202,
0.01269387174397707,
-0.021002046763896942,
0.012900820933282375,
0.012983179651200771,
-0.02089006081223488,
-0.009853296913206577,
0.004092467948794365,
-0.006338181439787149,
0.019921258091926575,
-0.006413660012185574,
-0.00005214894190430641,
-0.011781580746173859,
0.012829486280679703,
-0.01807282119989395,
0.0026365702506154776,
-0.011446205899119377,
-0.019374024122953415,
-0.011156448163092136,
0.00017283734632655978,
0.0029126922599971294,
-0.006701493635773659,
0.020346732810139656,
-0.01403946615755558,
0.013608433306217194,
0.017966976389288902,
0.003990689292550087,
-0.0033530418295413256,
0.006175551563501358,
-0.00824694987386465,
0.005141724832355976,
-0.01359762717038393,
-0.022788221016526222,
0.004496042616665363,
-0.015633713454008102,
0.014323161914944649,
0.0014555512461811304,
0.01426973007619381,
-0.015966881066560745,
0.0025955699384212494,
-0.010197491385042667,
0.034456804394721985,
0.010625507682561874,
-0.015783052891492844,
0.006502890959382057,
0.039672672748565674,
0.022995945066213608,
-0.01653127372264862,
-0.00019993167370557785,
0.006119075696915388,
0.0137602174654603,
-0.006696677301079035,
-0.025989625602960587,
0.003965332172811031,
0.01016736589372158,
-0.005795848555862904,
0.019695790484547615,
0.02601800486445427,
-0.0017330744303762913,
0.0008273455314338207,
0.005403620656579733,
-0.01572049967944622,
-0.0012238288763910532,
-0.017085188999772072,
0.024269986897706985,
-0.00595668563619256,
-0.025524809956550598,
0.0449100099503994,
0.0006095431745052338,
0.009572187438607216,
-0.01145083736628294,
-0.0034008545335382223,
-0.08119732141494751,
-0.017603900283575058,
-0.001552383415400982,
0.019259348511695862,
0.0030974801629781723,
-0.033227987587451935,
0.01896652765572071,
0.015433882363140583,
-0.0025707054883241653,
0.0005828256253153086,
-0.012204787693917751,
0.013634762726724148,
-0.013557602651417255,
0.022282114252448082,
-0.0012869713827967644,
-0.004548183176666498,
0.016857482492923737,
0.020316720008850098,
-0.046114712953567505,
-0.035526372492313385,
0.01015300489962101,
0.002312090015038848,
0.019046850502490997,
-0.004061075858771801,
0.011763985268771648,
0.00015198905020952225,
-0.0002852512989193201,
0.012291256338357925,
-0.03990890458226204,
0.007474214769899845,
-0.014675204642117023,
0.008109518326818943,
0.0014198380522429943,
0.0373028889298439,
-0.009724363684654236,
0.009026654064655304,
-0.005829229485243559,
-0.014903471805155277,
-0.024967964738607407,
0.0076371850445866585,
-0.017783313989639282,
-0.005316767375916243,
-0.0008949250914156437,
0.014977415092289448,
0.00044965045526623726,
-0.007520525716245174,
0.0006411252543330193,
0.04358403757214546,
0.022903110831975937,
-0.013152822852134705,
-0.001050267368555069,
-0.00019011180847883224,
0.01552700623869896,
0.01625194400548935,
-0.01579792983829975,
-0.00491280946880579,
-0.04788077622652054,
0.02042265608906746,
-0.00815933384001255,
-0.00930908601731062,
0.01863120123744011,
-0.001486476045101881,
0.012202817015349865,
-0.0058255791664123535,
-0.01877194084227085,
-0.018879510462284088,
0.014836862683296204,
0.005428280681371689,
0.009012708440423012,
0.01097028236836195,
-0.0006410293281078339,
0.0009726481512188911,
-0.016436360776424408,
0.0013888427056372166,
0.009139328263700008,
-0.013387170620262623,
-0.021510019898414612,
-0.025873474776744843,
0.026653096079826355,
-0.021623045206069946,
-0.012321919202804565,
0.00829087384045124,
0.032096799463033676,
-0.01283062994480133,
-0.010153395123779774,
0.014979705214500427,
0.0014331568963825703,
0.0015864484012126923,
0.005371145438402891,
-0.011781223118305206,
0.009376849979162216,
0.007261340972036123,
-0.021633809432387352,
0.0039033100474625826,
0.0015150520484894514,
0.017125923186540604,
-0.008666301146149635,
0.01010003499686718,
-0.0014465362764894962,
0.01078901719301939,
-0.006967701483517885,
-0.012148396112024784,
-0.027788948267698288,
-0.009657857939600945,
-0.029161369428038597,
0.013688534498214722,
0.0036368260625749826,
0.004831861704587936,
-0.022697649896144867,
-0.005106185097247362,
0.0014691869728267193,
0.00881242100149393,
-0.010439189150929451,
0.00015952519606798887,
0.01159515231847763,
0.05406241863965988,
0.004802456125617027,
-0.00048402068205177784,
0.07143862545490265,
0.012353666126728058,
0.01525522954761982,
0.00045990152284502983,
0.001897154375910759,
0.013520218431949615,
-0.027996132150292397,
-0.037127405405044556,
0.016359843313694,
-0.0029546432197093964,
0.013976162299513817,
-0.0031099868938326836,
-0.014592253603041172,
-0.008006172254681587,
-0.00662574078887701,
0.0134288240224123,
-0.03246277943253517,
-0.009056436829268932,
-0.014924000017344952,
0.010363421402871609,
0.004738534335047007,
-0.020840927958488464,
0.017426975071430206,
-0.036743707954883575,
-0.019909359514713287,
0.020148783922195435,
-0.01796729862689972,
-0.014476734213531017,
-0.012149572372436523,
0.016769912093877792,
0.00887464638799429,
-0.01780354604125023,
-0.008799903094768524,
-0.02845345064997673,
0.02080027386546135,
-0.011456065811216831,
0.008237671107053757,
0.010793307796120644,
-0.0020851874724030495,
0.0031944934744387865,
-0.006349459290504456,
-0.011262006126344204,
0.021704088896512985,
0.00850570946931839,
-0.008733021095395088,
-0.0070702191442251205,
-0.0162477046251297,
-0.005559492390602827,
-0.0064690676517784595,
0.011019947938621044,
0.006026571616530418,
0.009364552795886993,
0.016454046592116356,
-0.014151346869766712,
-0.0029568299651145935,
-0.028810154646635056,
0.011005672626197338,
0.002508102683350444,
-0.034135304391384125,
-0.029060974717140198,
0.026850571855902672,
0.043028272688388824,
0.005890746135264635,
0.0058591002598404884,
-0.019500497728586197,
-0.007896536029875278,
-0.014918968081474304,
-0.012139257974922657,
0.011830124072730541,
0.015011614188551903,
-0.012534378096461296,
-0.001991880824789405,
-0.00022945832461118698,
0.014087120071053505,
-0.007607011124491692,
0.02356639690697193,
-0.00488972058519721,
-0.015071355737745762,
0.009262559935450554,
0.018597546964883804,
0.029395105317234993,
0.0013959250645712018,
0.01104618888348341,
-0.0417448952794075,
0.00940471701323986,
-0.010493846610188484,
0.0012952112592756748,
-0.07434394955635071,
-0.01226578839123249,
0.01529775932431221,
-0.012218043208122253,
-0.023371659219264984,
0.030803121626377106,
-0.01610613986849785,
0.008818126283586025,
-0.017825346440076828,
-0.0038112124893814325,
-0.009156396612524986,
-0.01737075299024582,
0.007422506809234619,
0.00702304020524025,
0.012353688478469849,
0.015566905029118061,
-0.0087773147970438,
0.03175896406173706,
0.001318640075623989,
-0.007978455163538456,
0.010909531265497208,
0.024542640894651413,
-0.002433865563943982,
-0.004646571818739176,
0.0054776049219071865,
-0.08053766936063766,
-0.006690646056085825,
-0.0058874329552054405,
-0.0028430840466171503,
0.005990664474666119,
-0.007770160213112831,
0.002410917542874813,
-0.006026545539498329,
-0.012032238766551018,
-0.009865794330835342,
0.014106297865509987,
0.004439539276063442,
0.008548688143491745,
-0.020166706293821335,
-0.0489078164100647,
-0.007587168365716934,
0.0075814975425601006,
0.01891474984586239,
0.03185480833053589,
0.0170133039355278,
-0.015836555510759354,
0.007028867024928331,
-0.013358671218156815,
-0.009713776409626007,
-0.0028209611773490906,
0.014349617063999176,
-0.012945154681801796,
0.010162612423300743,
-0.0016025141812860966,
-0.05255655571818352,
0.013684160076081753,
-0.029961828142404556,
-0.025257889181375504,
-0.03464788198471069,
0.02086760476231575,
-0.017992470413446426,
0.008114820346236229,
-0.008802788332104683,
-0.026816867291927338,
0.0033543179742991924,
0.0047824024222791195,
0.0016674059443175793,
-0.009445112198591232,
0.0196380577981472,
0.0054117231629788876,
-0.01033240370452404,
0.0045127859339118,
-0.008541534654796124,
0.005352226085960865,
-0.007483293302357197,
0.011015338823199272,
0.002818431705236435,
-0.003389657475054264,
0.02612418681383133,
-0.037928059697151184,
-0.004559573717415333,
-0.0050271544605493546,
0.01718853786587715,
-0.009596552699804306,
0.0015924512408673763,
-0.00017591181676834822,
0.004846803843975067,
0.011940736323595047,
0.07125931233167648,
0.002786257304251194,
0.010618486441671848,
-0.023815328255295753,
-0.03227228671312332,
0.005768121220171452,
-0.033639781177043915,
0.007752570323646069,
0.005472704768180847,
-0.009436065331101418,
0.00999801978468895,
-0.007021911442279816,
0.016992786899209023,
0.012745948508381844,
0.008469347842037678,
0.00891423225402832,
0.035977818071842194,
-0.004198170267045498,
-0.026636537164449692,
0.004867349751293659,
0.022082015872001648,
-0.005803987383842468,
0.008975409902632236,
0.002238546498119831,
0.015022664330899715,
-0.00036141881719231606,
-0.0018536748830229044,
-0.022557513788342476,
-0.02777840942144394,
0.011019568890333176,
-0.0036131292581558228,
-0.009903493337333202,
0.004676868207752705,
0.014137623831629753,
0.021459810435771942,
-0.013344606384634972,
-0.001487109111621976,
0.01634434424340725,
0.006940342485904694,
-0.005517051089555025,
-0.0016387023497372866,
0.0030657933093607426,
-0.010280605405569077,
-0.013926416635513306,
-0.006112071685492992,
0.007073440123349428,
0.02079540677368641,
0.01820383034646511,
-0.012387176975607872,
0.013754088431596756,
0.017657872289419174,
-0.00002172822132706642,
-0.02331506833434105,
-0.01708347722887993,
-0.019288379698991776,
0.013353507965803146,
-0.0004116708878427744,
0.0027576969005167484,
-0.009492541663348675,
-0.010523831471800804,
-0.016439193859696388,
-0.014428812079131603,
-0.002716795774176717,
-0.006154464557766914,
-0.0033428859896957874,
-0.030915377661585808,
-0.010976271703839302,
-0.006864629685878754,
-0.014438198879361153,
0.010942751541733742,
-0.012360762804746628,
0.025866474956274033,
0.011296002194285393,
0.0055687609128654,
0.009769552387297153,
-0.000001914799213409424,
-0.01934725046157837,
-0.0038108511362224817,
0.008461018092930317,
0.004796425811946392,
-0.007542102597653866,
0.028580373153090477,
-0.01710163801908493,
0.010875342413783073,
0.012024715542793274,
0.0382370725274086,
0.01641097292304039,
0.012268614955246449,
0.003562900237739086,
-0.0005611683591268957,
-0.004283200018107891,
-0.0005409340374171734,
0.00759078748524189,
0.006470526568591595,
0.0009560897015035152,
0.03478037565946579,
0.0016581136733293533,
0.0023206351324915886,
0.02645307034254074,
-0.013932263478636742,
0.02287338115274906,
0.02346041426062584,
-0.01981520652770996,
0.026233628392219543,
0.013602113351225853,
0.009050286374986172,
-0.0038422676734626293,
0.005770239979028702,
-0.005645447410643101,
0.02367522194981575,
-0.006285373121500015,
0.02757364511489868,
0.017963901162147522,
0.00575985386967659,
-0.009372926317155361,
0.011083908379077911,
-0.004319730214774609,
0.016522569581866264,
-0.011294139549136162,
-0.016798989847302437,
0.018652833998203278,
0.015490425750613213,
-0.0002446852158755064,
-0.0058210850693285465,
-0.001226100604981184,
-0.008563429117202759,
-0.015992838889360428,
-0.017958207055926323,
0.009831174276769161,
0.012219220399856567,
0.007744300179183483,
-0.011016488075256348,
0.017638742923736572,
-0.014917001128196716,
0.02533436194062233,
-0.0070435116067528725,
0.04015717655420303,
0.05480499565601349,
-0.024976655840873718,
-0.01655006967484951,
-0.009809676557779312,
0.0005646215286105871,
-0.002282309578731656,
0.010412726551294327,
0.00878581777215004,
-0.0019936002790927887,
-0.007563184481114149,
0.004367348272353411,
0.0054584224708378315,
0.006198352202773094,
-0.011906929314136505,
-0.003341343253850937,
-0.002503868192434311,
-0.011195715516805649,
0.01314427051693201,
0.01599068008363247,
0.0006270474987104535,
-0.008106435649096966,
0.0025544383097440004,
-0.0005940757691860199,
0.05081245303153992,
-0.009048961102962494,
0.01403123140335083,
0.02246512845158577,
-0.031228642910718918,
0.03028622642159462,
0.01593683287501335,
0.01605289801955223,
-0.015613076277077198,
-0.014904794283211231,
-0.0057091545313596725,
-0.0006011743098497391,
-0.012776518240571022,
0.017167340964078903,
0.024686066433787346,
-0.004135907627642155,
-0.007845683954656124,
0.0017521223053336143,
-0.021684441715478897,
0.02573937177658081,
0.01696755364537239,
-0.04397273063659668,
0.006923974491655827,
-0.005502426065504551,
-0.0038686981424689293,
0.02421555295586586,
-0.00571371428668499,
-0.00991326104849577,
-0.0011270050890743732,
-0.008210672996938229,
-0.015473177656531334,
0.021785210818052292,
-0.015512770041823387,
-0.004624298773705959,
-0.0028007831424474716,
-0.016185786575078964,
0.0064581879414618015,
0.013519562780857086,
0.01417832262814045,
-0.024421326816082,
0.007960710674524307,
-0.019048836082220078
] | [
0.30431684851646423,
0.21729639172554016,
0.3897779583930969,
0.05808469280600548,
0.07419248670339584,
0.16786593198776245,
-0.027121545746922493,
-0.7540652751922607,
0.2948358356952667,
-0.20374511182308197,
-0.17053398489952087,
0.4764070212841034,
-0.32295000553131104,
0.2594490647315979,
0.4488689601421356,
0.6861310005187988,
0.8627645373344421,
0.5236443281173706,
-0.09802165627479553,
-0.26593148708343506,
-0.027128813788294792,
-0.4487690031528473,
0.4536869525909424,
-0.21337483823299408,
0.17703211307525635,
-0.17634712159633636,
0.62289959192276,
0.17793884873390198,
0.06300390511751175,
0.3854578733444214,
0.4861745238304138,
0.5217177867889404,
0.05066586658358574,
-0.3942507207393646,
0.7660969495773315,
0.14343374967575073,
-0.14164964854717255,
0.07434689253568649,
-0.17857597768306732,
-0.36009329557418823,
-0.39281895756721497,
-0.15601564943790436,
0.01233232207596302,
0.5151656866073608,
-0.5800410509109497,
-0.13855138421058655,
-1.1629866361618042,
0.3476634621620178,
-0.46209144592285156,
0.457206666469574,
0.11075060814619064,
-0.265127569437027,
0.3811493217945099,
0.274914026260376,
-0.0367884486913681,
0.3994913101196289,
-0.45569685101509094,
0.014487485401332378,
0.19041503965854645,
-0.1750020533800125,
0.13880696892738342,
-0.5348702073097229,
-0.15929770469665527,
0.1992458999156952,
0.1048274040222168,
0.6792322993278503,
0.01715647242963314,
-0.5352622866630554,
-0.34075382351875305,
0.45368561148643494,
0.3844279944896698,
0.011628128588199615,
-0.8179277181625366,
-0.06235506758093834,
-0.1602792739868164,
0.30223193764686584,
0.03307009115815163,
-0.3177623748779297,
-0.22712506353855133,
0.2759891152381897,
0.18649502098560333,
-0.12832877039909363,
0.4468071758747101,
0.1321564018726349,
0.2966333031654358,
0.33006832003593445,
-0.21241044998168945,
0.5445572137832642,
-0.5291836857795715,
-0.17194649577140808,
-0.40668392181396484,
0.1993420422077179,
0.5174641609191895,
1.0139824151992798,
0.21150611340999603,
-0.029159951955080032,
-0.24554038047790527,
-0.3381866216659546,
0.06386397033929825,
0.13875055313110352,
0.12422435730695724,
0.13325488567352295,
-0.06254668533802032,
0.36958199739456177,
-0.12149492651224136,
-0.20397450029850006,
-0.6778414845466614,
-0.5045427680015564,
-0.5683157444000244,
0.07314477115869522,
-0.46186789870262146,
0.47501274943351746,
0.09656918793916702,
-0.20266860723495483,
-0.5625916123390198,
-0.11775475740432739,
0.27188757061958313,
0.30055421590805054,
0.3926845192909241,
0.6044656038284302,
-0.10368094593286514,
1.5158605575561523,
-0.016604112461209297,
0.1111278161406517,
-0.0031588315032422543,
0.1355048418045044,
0.19282817840576172,
0.6593922972679138,
-0.5394095778465271,
0.7601836323738098,
-0.028010142967104912,
0.4512960910797119,
0.10430335253477097,
-0.28314682841300964,
0.042074549943208694,
-0.814591109752655,
-0.07355188578367233,
0.005071809981018305,
0.5019369721412659,
0.3739170432090759,
-0.40016889572143555,
-0.6389060616493225,
-0.09568984806537628,
-0.15310323238372803,
-0.23635238409042358,
-0.396266371011734,
0.020506825298070908,
0.019758909940719604,
-0.32648882269859314,
0.141211599111557,
0.05431918799877167,
-0.16995739936828613,
-0.5551361441612244,
-0.3230012059211731,
-0.35053929686546326,
0.2712792456150055,
-0.21448668837547302,
-0.007513455580919981,
-0.5725576877593994,
0.18751275539398193,
0.40723538398742676,
-0.0028638567309826612,
-0.2672043442726135,
-0.0699603259563446,
0.5506709218025208,
0.02484683319926262,
0.08389172703027725,
0.33105868101119995,
0.441176176071167,
0.3221893906593323,
0.4585359990596771,
-0.46319514513015747,
-0.09091788530349731,
-0.29163020849227905,
-0.0322737842798233,
0.1804777979850769,
0.307814359664917,
0.026825133711099625,
-0.26475098729133606,
0.18396134674549103,
-0.7694754004478455,
-0.09468600153923035,
-0.08769027888774872,
0.15381814539432526,
0.07235009223222733,
0.44328489899635315,
0.46477076411247253,
0.3653014898300171,
0.118135966360569,
0.2239057719707489,
-0.049564022570848465,
-0.15778450667858124,
0.5598296523094177,
-0.789280116558075,
1.252251386642456,
-0.09264614433050156,
-0.4057389199733734,
0.066111721098423,
-0.10698481649160385,
0.14415115118026733,
-0.26765909790992737,
0.4046906530857086,
0.5866022706031799,
-0.27584150433540344,
-0.6745399236679077,
-0.16681227087974548,
0.09930890798568726,
0.12780296802520752,
-0.14560124278068542,
0.04329685494303703,
0.7118781208992004,
-0.433824360370636,
0.3664321303367615,
0.014793869107961655,
0.33779191970825195,
-0.17426300048828125,
-0.0372578389942646,
0.026004010811448097,
0.31861409544944763,
0.4295178949832916,
0.4817420542240143,
-0.462007611989975,
0.22269222140312195,
0.5502805113792419,
-0.33505740761756897,
0.6007853150367737,
0.2986558973789215,
-0.23433218896389008,
0.5722053050994873,
-0.16232086718082428,
0.22556352615356445,
-0.4925219416618347,
0.16291987895965576,
-0.3458865284919739,
-0.3152811825275421,
-0.006184275262057781,
0.084138423204422,
0.21014678478240967,
0.758729100227356,
0.19054153561592102,
-0.15161438286304474,
0.3493488132953644,
-0.4246178865432739,
0.44670990109443665,
0.12067617475986481,
-0.47556596994400024,
0.21438071131706238,
0.11561089009046555,
-0.2534955143928528,
-0.2178877890110016,
0.0874943807721138,
-0.16219371557235718,
-0.2779584228992462,
-0.4606790542602539,
0.1988278180360794,
-0.4363473951816559,
-0.13563480973243713,
-0.2507985234260559,
-0.06372284144163132,
-0.3330135643482208,
-0.6411171555519104,
-0.19306614995002747,
0.38340505957603455,
-0.2519015967845917,
0.06546741724014282,
-0.3959415853023529,
-0.6755802631378174,
-0.14912453293800354,
0.42653971910476685,
0.2997282147407532,
0.12203910946846008,
0.23309388756752014,
-0.13006867468357086,
-0.2386646270751953,
-0.11070293933153152,
-0.33853447437286377,
-0.01554137747734785,
0.32210713624954224,
-0.5616706013679504,
-0.4065830111503601,
0.37366634607315063,
0.8593683242797852,
0.7097808718681335,
-0.1773046851158142,
-0.7377834320068359,
-0.10291579365730286,
-0.00852137804031372,
-0.795225203037262,
-0.37329137325286865,
-0.7045839428901672,
-0.29329073429107666,
0.39688539505004883,
-0.16508230566978455,
-0.13993379473686218,
-0.034502461552619934,
0.5987575650215149,
-0.1159994825720787,
0.248716801404953,
0.5176766514778137,
-0.23051242530345917,
-0.2233637422323227,
-0.21486322581768036,
-0.9531121850013733,
0.1720883548259735,
0.09358198195695877,
-0.12022237479686737,
-0.3824099898338318,
0.08850257098674774,
-6.013841152191162,
0.4988122284412384,
-0.0662221759557724,
0.17348934710025787,
-0.24807964265346527,
0.08523260802030563,
0.850355327129364,
-0.04837052896618843,
0.44137170910835266,
0.08100695163011551,
-0.4653404653072357,
0.503349244594574,
-0.10952074080705643,
0.16878820955753326,
0.1521240919828415,
0.4083782136440277,
0.3191535472869873,
-0.6883823275566101,
0.5981020927429199,
-0.08667709678411484,
0.08276058733463287,
0.008847659453749657,
-0.2189060002565384,
0.37938788533210754,
0.5890563726425171,
0.1075969785451889,
-0.8529126048088074,
0.16920621693134308,
-0.45145925879478455,
-0.28012415766716003,
-0.01044168509542942,
-0.6684079170227051,
-0.3090022802352905,
-0.17054657638072968,
0.5614480972290039,
0.35293781757354736,
0.152126744389534,
-0.28344282507896423,
-0.4049042761325836,
-0.3326829969882965,
0.5627202987670898,
0.35654470324516296,
-0.3261215090751648,
-0.08860118687152863,
0.06785367429256439,
0.025074215605854988,
-0.4275277256965637,
-0.2039797455072403,
0.34212589263916016,
0.4844670593738556,
-0.06084165349602699,
0.10536172986030579,
-0.00530841713771224,
0.1767793595790863,
-0.07124370336532593,
0.25325727462768555,
-0.05173749104142189,
0.35572776198387146,
-0.17671459913253784,
-0.2469947785139084,
-0.8138657212257385,
0.22397837042808533,
-0.36649519205093384,
-0.3281552195549011,
0.3229874074459076,
0.5029703974723816,
-0.07084129005670547,
-0.48334062099456787,
0.3783233165740967,
-0.05167023092508316,
-0.4682600498199463,
0.14079812169075012,
-0.16055350005626678,
-0.8441600203514099,
0.1958373337984085,
-0.17775402963161469,
0.5063341856002808,
-0.27332159876823425,
-0.3638848662376404,
0.008161854930222034,
-0.3855966031551361,
-0.1722644716501236,
0.258979469537735,
0.25880250334739685,
0.02911793813109398,
-0.2515185475349426,
-0.06442184001207352,
-0.28775665163993835,
0.06866166740655899,
0.29189440608024597,
0.9195370674133301,
-0.17570091784000397,
-0.04714565724134445,
0.08096788823604584,
0.21714748442173004,
0.16687890887260437,
0.46048441529273987,
0.20525777339935303,
0.5241429805755615,
0.20613239705562592,
0.382610023021698,
0.4950447082519531,
-0.25061360001564026,
-0.9404475092887878,
-0.22039441764354706,
0.3374567925930023,
-0.5543294548988342,
-0.010130366310477257,
0.18428301811218262,
-0.5680336952209473,
0.07026529312133789,
-0.01567280851304531,
0.04948481544852257,
0.36847594380378723,
1.0380051136016846,
-0.03923257812857628,
-0.06415001302957535,
0.3140363395214081,
0.5626407861709595,
-0.3344082534313202,
0.09605038911104202,
-0.04022536426782608,
-0.17823468148708344,
-0.33160334825515747,
0.03842264413833618,
-0.02956872060894966,
-0.10666516423225403,
0.685756266117096,
-0.605517566204071,
0.41336575150489807,
0.09409832209348679,
0.2432316690683365,
-0.569727897644043,
-0.3306243121623993,
0.11929789930582047,
-0.35773807764053345,
-0.6467891931533813,
-0.13542768359184265,
0.1378200501203537,
0.0061761001124978065,
0.24911844730377197,
-0.4233996570110321,
0.18170632421970367,
0.27291297912597656,
0.4029485583305359,
-0.006719055585563183,
0.28283849358558655,
-0.3108535706996918,
-0.10779530555009842,
-0.05477355793118477,
0.17988921701908112,
-0.16115519404411316,
0.3381249010562897,
-0.1110842376947403,
-0.32628458738327026,
0.08456747978925705,
0.6993917226791382,
0.2917664051055908,
-0.04348604008555412,
-0.32832297682762146,
0.5828754305839539,
0.6566972136497498,
-1.0180310010910034,
0.17128896713256836,
-0.1107039749622345,
-0.6627854108810425,
-0.45520779490470886,
0.3349766135215759,
-0.15905773639678955,
0.32002580165863037,
-0.08369245380163193,
-0.5770304203033447,
-0.2903788387775421,
-0.37848514318466187,
0.3249048888683319,
-0.05768084153532982,
0.03336302191019058,
-0.10590090602636337,
0.17149880528450012,
-0.6444656252861023,
0.06260184943675995,
-0.1782851666212082,
-0.3545413017272949,
0.5866608619689941,
0.643664538860321,
-0.11021487414836884,
-0.43792882561683655,
-0.21196730434894562,
-0.24909885227680206,
-0.335948646068573,
0.5612987279891968,
-0.06989220529794693,
0.0853414312005043,
0.06307082623243332,
-0.2569439113140106,
-0.4996489882469177,
0.12533850967884064,
0.5702148675918579,
-0.3287951946258545,
-0.4991525709629059,
-0.175371453166008,
0.05320040509104729,
-0.9016600847244263,
0.37545347213745117,
-0.20028038322925568,
-0.3677244782447815,
-0.1506994068622589,
0.7067853808403015,
-0.14679810404777527,
-0.09325031191110611,
-0.1621907651424408,
-0.48883840441703796,
-0.18298104405403137,
-0.08162993937730789,
-0.38789427280426025,
0.46200188994407654,
0.2561788558959961,
0.1679387241601944,
-0.1801745593547821,
-0.4584943354129791,
0.3907085955142975,
-0.6059529185295105,
0.46681419014930725,
-0.0842631533741951,
-0.25860926508903503,
0.18036536872386932,
0.690639317035675,
-0.12753598392009735,
-0.4142725169658661,
0.2191288322210312,
0.08330073207616806,
0.13000673055648804,
0.04589781165122986,
0.23566924035549164,
-0.3610590994358063,
-0.002998925279825926,
-0.9258488416671753,
-0.0988471582531929,
-0.16547778248786926,
0.35305294394493103,
-0.08453696966171265,
-0.3875802159309387,
-0.49979251623153687,
-0.04649541154503822,
-0.27202728390693665,
0.16503551602363586,
0.13140730559825897,
-0.07648676633834839,
-0.8771761059761047,
-0.19559471309185028,
0.5166025161743164,
-0.281669944524765,
0.11167871952056885,
-0.35369399189949036,
0.8187089562416077,
0.05529814586043358,
0.22993363440036774,
-0.40356412529945374,
-0.3333317041397095,
0.4357486367225647,
-0.794028103351593,
-0.2664185166358948,
-0.4205096662044525,
-0.17932406067848206,
-0.15699532628059387,
0.09530146420001984,
-0.25401321053504944,
-1.0198602676391602,
0.11903533339500427,
-0.06785546243190765,
-0.193664088845253,
0.05551361292600632,
0.9670479893684387,
0.5464873313903809,
-0.29969528317451477,
0.13139213621616364,
-0.31742632389068604,
0.10848195105791092,
-0.22534069418907166,
0.2125146985054016,
-0.4010732173919678,
-0.26079538464546204,
0.5280399918556213,
0.13274100422859192,
0.019533377140760422,
-0.23399335145950317,
-0.011629629880189896,
0.08439115434885025,
-0.1756119430065155,
-0.13361525535583496,
0.14556609094142914,
0.29604557156562805,
-0.5733374953269958,
-0.612433671951294,
0.09647577255964279,
0.3550224006175995,
0.0188718531280756,
0.2705446779727936,
-0.3069450259208679,
-0.4248035252094269,
-0.30123311281204224,
0.7283949255943298,
0.7613070607185364,
-0.020526953041553497,
0.28480780124664307,
0.01456401962786913,
0.9590200781822205,
0.11303785443305969,
-0.4142473638057709,
-0.3192555606365204,
0.2419285774230957,
0.1814420223236084,
-0.5736570954322815,
0.5196428894996643,
-0.4623119831085205,
0.3061133325099945,
0.06062154844403267,
-0.043581850826740265,
0.5998740792274475,
0.11072057485580444,
0.24545885622501373,
0.2419995367527008,
0.3945706784725189,
-0.1664266586303711,
-0.5369213819503784,
0.333555668592453,
0.2151799499988556,
0.03299201652407646,
0.2155091017484665,
0.3343670666217804,
0.4489836096763611,
0.11438440531492233,
-0.13156120479106903,
0.14346696436405182,
0.13729017972946167,
0.34538760781288147,
-0.5950027108192444,
-0.19057948887348175,
-0.6229180097579956,
0.667966902256012,
0.6412563323974609,
0.6295188665390015,
-0.3393469452857971,
-0.25992217659950256,
0.31160932779312134,
0.5902390480041504,
-0.008393296040594578,
-0.06597783416509628,
-0.06145088002085686,
0.686042845249176,
-0.1668831706047058,
-0.0899437740445137,
-0.178715780377388,
-0.2607836127281189,
-0.8726319670677185,
-0.09321202337741852,
0.3817729949951172,
-0.06440240144729614,
-0.16972559690475464,
0.2635078728199005,
0.08783727884292603,
0.6454001665115356,
-0.2697768807411194,
0.43963924050331116,
-0.7561927437782288,
-0.04547116532921791,
0.15513963997364044,
0.3532950282096863,
-0.1645827293395996,
-0.2550859749317169,
0.13812139630317688,
-0.10728926211595535,
-0.07131224125623703,
0.46847373247146606,
0.15881997346878052,
-0.3427595794200897,
0.35608136653900146,
-0.3343900144100189,
-0.13010568916797638,
0.38470572233200073,
-0.2707706093788147,
0.3544796109199524,
-0.6138021349906921,
-0.38722923398017883,
-0.11071474105119705,
-0.0836709588766098,
-0.24765025079250336,
0.2842293679714203,
-0.26099780201911926,
-0.07750114053487778,
0.121821828186512,
-0.2665160894393921,
0.010003207251429558,
0.11418730020523071,
-0.270313560962677,
-0.009180924855172634,
-0.028132906183600426,
0.28444716334342957,
0.20849740505218506,
-0.14714689552783966,
0.37398561835289,
0.040609538555145264,
0.28031784296035767,
0.6739912033081055,
-0.37146255373954773,
0.645854651927948,
-0.9278413653373718,
0.12996141612529755,
-0.6794662475585938,
-0.14999891817569733,
0.716901957988739,
0.23920346796512604,
0.06725513190031052,
0.041569784283638,
-0.0318269245326519,
-0.09466737508773804,
0.23254886269569397,
-0.25890642404556274,
-0.27069929242134094,
-0.2958430349826813,
-0.04815232753753662,
-0.656432032585144,
0.2025666981935501,
-0.1841675043106079,
0.06807168573141098,
-0.08562777191400528,
0.5129637718200684,
0.4551086127758026,
0.44137120246887207,
0.07098432630300522,
0.5621288418769836,
-0.1136646494269371,
-0.5225029587745667,
0.4697057008743286,
-0.6756511330604553,
-0.25228503346443176,
-0.2719278931617737,
0.3414457142353058,
-0.4696614444255829,
-0.2270633429288864,
-0.06645704805850983,
-0.54712975025177,
-0.05258582904934883,
-0.2700056731700897,
-0.026239629834890366,
0.04040401428937912,
-0.1938912570476532,
-0.40116795897483826,
-0.49433448910713196,
0.3522188067436218,
-0.03121212124824524,
-0.47805872559547424,
-0.006521525327116251,
0.22770439088344574,
-0.1863558441400528,
-0.3778468370437622,
-0.12470382452011108,
0.04646461457014084,
0.07849974930286407,
-0.3173369765281677
] |
Abstract In this article we discuss our experience designing and implementing a statistical computing language. In developing this new language, we sought to combine what we felt were useful features from two existing computer languages. We feel that the new language provides advantages in the areas of portability, computational efficiency, memory management, and scoping. | [
-0.007878473028540611,
0.01853916049003601,
-0.00965996365994215,
0.008484292775392532,
-0.026190536096692085,
-0.005449641961604357,
0.011740350164473057,
-0.018218209967017174,
-0.017692191526293755,
-0.009304296225309372,
-0.005589654203504324,
0.020541630685329437,
-0.004827137570828199,
0.020505132153630257,
0.030755408108234406,
-0.026628144085407257,
0.00395277701318264,
0.0034817212726920843,
0.007254850585013628,
-0.01080450788140297,
-0.017596611753106117,
0.006162825971841812,
0.011823144741356373,
0.00026770163094624877,
-0.0034009949304163456,
0.02112507075071335,
-0.007859822362661362,
0.013046053238213062,
-0.0035267879720777273,
-0.04706673324108124,
-0.03196725994348526,
0.003909514285624027,
0.0186969842761755,
-0.009395487606525421,
-0.0022236965596675873,
0.007145358715206385,
-0.004052348900586367,
0.022763077169656754,
-0.02393350377678871,
-0.004430912435054779,
0.011114773340523243,
0.004406393971294165,
0.00846182182431221,
0.003359328955411911,
-0.011217569001019001,
0.03371521830558777,
-0.0024402241688221693,
0.020679131150245667,
0.008775053545832634,
0.01582777127623558,
-0.012882551178336143,
0.00959573220461607,
0.0007914442685432732,
0.03371499478816986,
-0.008596405386924744,
-0.03609973192214966,
0.02205662429332733,
0.00841735303401947,
-0.007915612310171127,
-0.0034287471789866686,
-0.006972500588744879,
0.019652992486953735,
0.036585092544555664,
0.013469611294567585,
-0.014172816649079323,
-0.06604993343353271,
-0.03044312261044979,
0.009876874275505543,
-0.001119849388487637,
0.022114776074886322,
0.0008679283200763166,
0.01173376850783825,
-0.008031785488128662,
0.04355061799287796,
-0.02752767875790596,
0.04083549231290817,
-0.013052553869783878,
-0.0025692442432045937,
-0.014891764149069786,
-0.018225083127617836,
-0.02993064373731613,
-0.005432120058685541,
-0.022858651354908943,
0.011024679988622665,
0.012379804626107216,
0.0073251137509942055,
-0.0027373626362532377,
-0.00554353091865778,
-0.007094572763890028,
-0.0006591731798835099,
0.023883042857050896,
-0.026812173426151276,
-0.006338122766464949,
0.03530493751168251,
-0.029429540038108826,
-0.0007039577467367053,
0.00013768943608738482,
0.016680706292390823,
0.01486633438616991,
-0.023580366745591164,
-0.011965479701757431,
0.015802651643753052,
0.03607400879263878,
-0.006135319359600544,
0.014205452986061573,
0.011234200559556484,
-0.00029775817529298365,
0.021687395870685577,
0.018261371180415154,
0.0027183748316019773,
0.008349561132490635,
0.016851775348186493,
0.006022216286510229,
-0.006770634092390537,
-0.007448350079357624,
-0.03172341361641884,
-0.0037316051311790943,
-0.002254227874800563,
0.007584942039102316,
0.015288547612726688,
0.026742050424218178,
-0.014115942642092705,
0.0077204215340316296,
0.022702019661664963,
0.00358862173743546,
0.011363069526851177,
0.009767374955117702,
-0.0027696292381733656,
-0.01846914365887642,
0.012363622896373272,
-0.016469409689307213,
-0.0060529340989887714,
-0.0004775968845933676,
0.0046096136793494225,
0.017712164670228958,
-0.0057180821895599365,
-0.012372356839478016,
-0.0005948959151282907,
0.007331265136599541,
0.0003060538147110492,
0.0036539018619805574,
0.013159768655896187,
-0.010794245637953281,
0.020404819399118423,
0.03655589744448662,
-0.015647877007722855,
0.04042024165391922,
0.01274463627487421,
-0.010525761172175407,
-0.0058503057807683945,
0.04606424644589424,
-0.005195233039557934,
-0.0025097799953073263,
-0.030670197680592537,
0.009497134946286678,
0.017789194360375404,
0.0017968445317819715,
-0.0049782199785113335,
-0.027713017538189888,
-0.002074121031910181,
0.00023095851065590978,
-0.0072374967858195305,
0.0276950616389513,
0.012274103239178658,
0.012186840176582336,
0.009849735535681248,
-0.015507170930504799,
-0.005448073148727417,
-0.0003888239152729511,
0.0003244601539336145,
-0.011897807940840721,
0.04277300834655762,
-0.012064497917890549,
0.015890227630734444,
-0.010283509269356728,
0.0009084595367312431,
0.03124988079071045,
0.005394882522523403,
0.0003952094994019717,
0.0665086954832077,
-0.0030337960924953222,
0.026839299127459526,
-0.0030966619960963726,
-0.003527675988152623,
-0.0017626131884753704,
-0.02361118420958519,
0.005340549163520336,
-0.011353389360010624,
-0.016402537003159523,
-0.013628278858959675,
-0.010251389816403389,
0.0055005233734846115,
-0.016046807169914246,
0.005652459803968668,
-0.004499522037804127,
0.006402005907148123,
0.0014610723592340946,
-0.00045727600809186697,
0.011488458141684532,
0.012776385061442852,
-0.00685739703476429,
0.0469224639236927,
0.04835152253508568,
0.012967467308044434,
-0.014497221447527409,
0.005717260297387838,
0.01271806936711073,
-0.026965318247675896,
-0.0029201912693679333,
0.018344640731811523,
0.018180949613451958,
0.024757739156484604,
-0.011291373521089554,
-0.01974303461611271,
0.01454404927790165,
0.02210353873670101,
0.01310480572283268,
-0.012504983693361282,
0.002427545376121998,
-0.016764434054493904,
-0.0003489988448563963,
-0.02621065080165863,
0.03104279935359955,
0.0026850970461964607,
0.027137290686368942,
-0.01407671719789505,
-0.010842169634997845,
0.012336721643805504,
0.014674905687570572,
-0.02240491658449173,
-0.004684582818299532,
-0.021212123334407806,
-0.006511158309876919,
-0.01616729237139225,
-0.014987220056355,
-0.014533603563904762,
0.009567040018737316,
0.006062895059585571,
0.025787901133298874,
-0.013506089337170124,
0.0024876571260392666,
-0.003515040036290884,
0.020753582939505577,
-0.05996956303715706,
-0.005943580064922571,
0.007996044121682644,
0.0008505411096848547,
-0.003251770744100213,
0.005446820519864559,
0.004963841754943132,
0.001301179057918489,
0.016506260260939598,
-0.008084993809461594,
-0.020533770322799683,
0.018807880580425262,
0.008445820771157742,
0.011571536771953106,
-0.002469971776008606,
0.027943622320890427,
-0.015228582546114922,
0.0007421785267069936,
0.0034916435834020376,
-0.024749737232923508,
0.017108647152781487,
0.002569118281826377,
0.04186554625630379,
0.015198104083538055,
0.008927697315812111,
0.01339448057115078,
-0.016443852335214615,
0.005645953118801117,
-0.008059467189013958,
0.013415967114269733,
-0.08173494786024094,
-0.023546461015939713,
0.006485984195023775,
0.005556394811719656,
0.019283371046185493,
-0.022273221984505653,
-0.025671156123280525,
0.006516550201922655,
-0.016854919493198395,
0.021696677431464195,
-0.02312609553337097,
-0.015085304155945778,
-0.009075849317014217,
-0.003685369621962309,
0.044413063675165176,
-0.01132684201002121,
0.009752647019922733,
0.00009128880628850311,
-0.030474450439214706,
0.013475851155817509,
-0.019287962466478348,
-0.028138738125562668,
0.019413745030760765,
-0.012514491565525532,
0.012787370942533016,
0.027225906029343605,
-0.011866983026266098,
0.009263181127607822,
0.026708468794822693,
0.008607160300016403,
0.01750776916742325,
-0.042740438133478165,
0.007883189246058464,
-0.006927469279617071,
0.00711079640313983,
0.015552571043372154,
-0.004040866158902645,
0.014680158346891403,
-0.005068824160844088,
0.02347768098115921,
0.006886185146868229,
0.01199000421911478,
-0.002009931020438671,
-0.000011632049790932797,
0.014580396004021168,
0.020069552585482597,
0.030519504100084305,
-0.004776133690029383,
0.010853077284991741,
-0.011746283620595932,
0.005671647377312183,
-0.0023216407280415297,
0.005225528962910175,
0.010925251059234142,
-0.0047611971385777,
-0.017507251352071762,
0.003124288748949766,
0.005001417826861143,
-0.016117654740810394,
0.0024325319100171328,
-0.01724204048514366,
-0.008098484016954899,
0.007279741112142801,
0.004647624213248491,
-0.026697613298892975,
-0.02854137308895588,
0.005624150857329369,
-0.0022996640764176846,
0.00899728387594223,
0.007156721781939268,
0.02230551466345787,
-0.04764170944690704,
0.01605590060353279,
0.004203767515718937,
-0.010014361701905727,
-0.027062108740210533,
-0.018763434141874313,
-0.0060104141011834145,
0.04417752847075462,
0.02223014272749424,
-0.0038118420634418726,
-0.005485480651259422,
-0.021184632554650307,
-0.016740979626774788,
-0.026009436696767807,
-0.01148558035492897,
0.0043102167546749115,
-0.012072288431227207,
0.001854004105553031,
-0.013513432815670967,
-0.02325737103819847,
0.023763133212924004,
0.02663300558924675,
0.002392736030742526,
0.02382882498204708,
-0.003545593935996294,
0.010473519563674927,
-0.008564010262489319,
0.004123503342270851,
0.011905393563210964,
0.027719562873244286,
0.011782252229750156,
-0.026521947234869003,
-0.01852816343307495,
0.009898551739752293,
0.0014667864888906479,
-0.014194846153259277,
-0.0058558001182973385,
0.01701905019581318,
-0.015403672121465206,
-0.0030442040879279375,
-0.021277593448758125,
-0.011682620272040367,
-0.0006538995075970888,
0.007701088208705187,
-0.03510112687945366,
-0.023702174425125122,
0.004396542441099882,
0.07088548690080643,
0.03048461489379406,
0.015660079196095467,
-0.019923940300941467,
-0.023766329512000084,
-0.004590651486068964,
-0.04540235549211502,
0.0009037127601914108,
0.021819505840539932,
0.00017605361063033342,
0.016648905351758003,
0.010640379972755909,
0.008341568522155285,
-0.019928310066461563,
-0.013046549633145332,
-0.016127169132232666,
0.03212319687008858,
-0.005158822983503342,
0.02329302206635475,
0.01871606707572937,
-0.002412109635770321,
-0.003162299981340766,
0.0035985992290079594,
0.005732330959290266,
-0.0016711738426238298,
-0.021880216896533966,
0.01497691124677658,
-0.014208692125976086,
-0.010444387793540955,
-0.00021079972793813795,
0.0068604545667767525,
0.00003128611569991335,
-0.0034859131556004286,
-0.01860121451318264,
0.001811349531635642,
0.022182399407029152,
-0.008711743168532848,
-0.026220470666885376,
-0.013870838098227978,
0.007671454455703497,
0.017198750749230385,
-0.014459873549640179,
-0.03407055884599686,
0.025738388299942017,
0.0017506818985566497,
-0.005161195993423462,
0.020814817398786545,
-0.0059938495978713036,
0.020946726202964783,
0.017676470801234245,
-0.011833187192678452,
0.019023066386580467,
0.01647796481847763,
0.037102293223142624,
-0.015148027800023556,
0.01519049983471632,
0.00026032375171780586,
-0.00394606264308095,
-0.018643973395228386,
0.03297997638583183,
-0.0052880337461829185,
0.0026263666804879904,
0.04204040765762329,
-0.035716712474823,
-0.028923241421580315,
-0.017968157306313515,
0.008385221473872662,
-0.004888341296464205,
-0.031293705105781555,
0.015875089913606644,
0.016299240291118622,
-0.015721317380666733,
-0.0030694343149662018,
-0.013173343613743782,
-0.010553563013672829,
-0.0058557805605232716,
0.0314381867647171,
0.0279218852519989,
-0.027698278427124023,
-0.03902388736605644,
0.026103375479578972,
0.008114059455692768,
-0.04594726860523224,
0.0042528812773525715,
-0.024015629664063454,
-0.0012268659193068743,
0.009388563223183155,
-0.07331378757953644,
-0.033610086888074875,
0.007132573984563351,
-0.013166212476789951,
-0.020192814990878105,
0.037565771490335464,
-0.010376458056271076,
0.027721131220459938,
-0.001658578752540052,
-0.0053045437671244144,
0.01867046020925045,
-0.011103307828307152,
-0.010514247231185436,
-0.019185632467269897,
0.008789528161287308,
-0.0338863879442215,
0.007052053697407246,
0.0012007973855361342,
0.022912515327334404,
-0.02377915382385254,
0.016130132600665092,
0.019329197704792023,
-0.024538196623325348,
0.00782135408371687,
-0.0044031403958797455,
-0.08003728091716766,
-0.003054162720218301,
-0.0071184029802680016,
0.010106352157890797,
0.002217014553025365,
-0.014483868144452572,
-0.014502346515655518,
0.004653453826904297,
-0.001557867624796927,
-0.018808960914611816,
0.013120387680828571,
0.0010781680466607213,
0.012514431029558182,
-0.007726451847702265,
0.0053481776267290115,
0.00580344395712018,
0.007153286132961512,
-0.03360460326075554,
0.017531486228108406,
0.021400798112154007,
0.029834870249032974,
0.004738861694931984,
-0.009547251276671886,
0.009572798386216164,
-0.015323810279369354,
-0.009053546003997326,
-0.01929028332233429,
0.013750401325523853,
0.0026472192257642746,
0.0033330677542835474,
-0.004443884361535311,
-0.013026826083660126,
-0.013525661081075668,
-0.0061666578985750675,
-0.028075994923710823,
-0.0038516155909746885,
-0.019981270655989647,
-0.012694623321294785,
-0.017722144722938538,
0.010741516016423702,
-0.004350895062088966,
-0.014380104839801788,
0.012871888466179371,
0.030993100255727768,
-0.006140546407550573,
0.0008831710438244045,
0.0024496426340192556,
0.0021889270283281803,
0.004746355582028627,
0.02405388094484806,
0.020169567316770554,
-0.0017468061996623874,
0.00960676372051239,
-0.021114163100719452,
-0.02018178068101406,
0.031159358099102974,
-0.0083184614777565,
0.02073594368994236,
0.01190157886594534,
0.008196640759706497,
0.007217608392238617,
0.037057068198919296,
-0.03382530063390732,
0.07119706273078918,
-0.027755025774240494,
-0.0030676766764372587,
-0.027282610535621643,
-0.0006804565782658756,
-0.006197243928909302,
0.0069414530880749226,
0.00436997227370739,
0.024450795724987984,
-0.015217427164316177,
0.008882232941687107,
0.010090652853250504,
0.02625895105302334,
0.004592017736285925,
0.051872432231903076,
-0.031020598486065865,
-0.021399136632680893,
-0.017949609085917473,
-0.017487479373812675,
-0.0019262839341536164,
0.018877990543842316,
0.013630599714815617,
-0.020932259038090706,
0.026399265974760056,
-0.0035212270449846983,
-0.023652473464608192,
-0.028903335332870483,
0.0036542622838169336,
0.006463080644607544,
-0.030769087374210358,
-0.009164679795503616,
-0.011629030108451843,
-0.002597876824438572,
0.03511510789394379,
0.02953644096851349,
-0.0037034167908132076,
0.016936223953962326,
0.0021694430615752935,
-0.029030941426753998,
-0.00242459774017334,
-0.01184244453907013,
-0.0012769970344379544,
0.007313047535717487,
0.011625079438090324,
0.03368401154875755,
0.02400316298007965,
0.05415540933609009,
0.005657962989062071,
-0.011187002062797546,
0.012438501231372356,
0.013958997093141079,
0.004713800735771656,
-0.012526330538094044,
-0.007879510521888733,
-0.00794267375022173,
-0.02677115611732006,
0.006039577070623636,
0.017792291939258575,
-0.0015408743638545275,
-0.01610621251165867,
-0.016562853008508682,
-0.008117983117699623,
-0.017599934712052345,
-0.011024740524590015,
-0.012988190166652203,
-0.005603282246738672,
0.019283464178442955,
-0.017854513600468636,
-0.015133503824472427,
0.01180752832442522,
0.02380385249853134,
-0.00008343115041498095,
0.0029388312250375748,
-0.025517772883176804,
0.024889212101697922,
0.012612152844667435,
-0.00023808171681594104,
-0.028667742386460304,
0.01647377200424671,
0.005786060355603695,
0.006958037614822388,
0.014149826020002365,
0.04059809446334839,
-0.014961409382522106,
0.01590009219944477,
0.037979964166879654,
-0.007593594025820494,
0.022591132670640945,
0.0055189491249620914,
0.008727377280592918,
0.027578270062804222,
0.0006983844796195626,
-0.013167371973395348,
0.02863316237926483,
0.004370659589767456,
0.037005677819252014,
-0.016296321526169777,
0.004415386822074652,
0.006084616295993328,
0.028532657772302628,
-0.03143490478396416,
0.008932700380682945,
-0.007944089360535145,
0.008343620225787163,
-0.0068617817014455795,
-0.010268413461744785,
0.05713885650038719,
0.030914902687072754,
-0.006067825015634298,
-0.014332236722111702,
0.011606930755078793,
0.012673706747591496,
-0.012063851580023766,
0.03103191964328289,
-0.0023056864738464355,
0.00872835237532854,
-0.008747056126594543,
0.0034118255134671926,
0.005037580616772175,
-0.009443748742341995,
-0.0098597202450037,
0.019876889884471893,
0.0002296607563039288,
0.022551391273736954,
-0.005573519505560398,
-0.0025880245957523584,
-0.0038203697185963392,
0.02494785189628601,
-0.026459168642759323,
-0.011354011483490467,
-0.013150503858923912,
-0.004659952595829964,
0.0192637350410223,
0.028055671602487564,
0.01264217309653759,
0.025930311530828476,
0.02950245700776577,
-0.018610751256346703,
0.019844308495521545,
0.015713587403297424,
-0.01628582738339901,
-0.028744671493768692,
-0.004018816165626049,
0.012773987837135792,
0.009029182605445385,
-0.004156483802944422,
-0.0009357958333566785,
0.015298847109079361,
0.010966038331389427,
0.028592925518751144,
0.0048187896609306335,
0.009893111884593964,
0.026316242292523384,
-0.0066399420611560345,
0.004424579441547394,
0.022367553785443306,
-0.01877363957464695,
-0.000319702725391835,
-0.023074856027960777,
0.03648904711008072,
0.003258566139265895,
-0.04855012148618698,
-0.02039000391960144,
0.0021108798682689667,
0.01147942990064621,
0.03968442603945732,
0.005647605285048485,
0.04423484951257706,
-0.005358395166695118,
-0.027453504502773285,
-0.010009917430579662,
-0.024012869223952293,
-0.031348735094070435,
-0.003755016718059778,
-0.005881697870790958,
-0.022575730457901955,
-0.02811318449676037,
0.018033605068922043,
-0.009846237488090992,
0.010252327658236027,
0.020344210788607597,
-0.02175917848944664,
0.009350505657494068,
-0.00876269955188036,
-0.008232912980020046,
-0.011543218977749348,
-0.0038342364132404327,
-0.0008944717701524496,
0.004481349606066942,
-0.025296596810221672,
0.023565638810396194,
0.034978680312633514,
-0.032762449234724045,
0.006081635598093271,
-0.013914442621171474,
-0.048152729868888855,
-0.005835851188749075,
0.018000418320298195,
-0.002583351917564869,
-0.014323851093649864,
0.048793770372867584,
-0.019784636795520782
] | [
0.36716902256011963,
0.18503795564174652,
-0.06254211813211441,
0.09653778374195099,
-0.314165860414505,
0.035843949764966965,
-0.1587667018175125,
-0.28848445415496826,
-0.01813480257987976,
-0.6139827370643616,
0.020196132361888885,
0.3529142737388611,
-0.11315231025218964,
-0.29232993721961975,
-0.2293616086244583,
0.13989032804965973,
0.2591789662837982,
0.33963510394096375,
0.1118270754814148,
-0.25094088912010193,
-0.310825377702713,
0.11051919311285019,
-0.29436546564102173,
-0.16387197375297546,
0.40842384099960327,
0.12453074008226395,
0.41738787293434143,
0.3698723018169403,
-0.5680715441703796,
-0.2914717197418213,
0.07223039120435715,
0.2806587517261505,
-0.309369295835495,
-0.24221065640449524,
-0.3414061367511749,
-0.21627433598041534,
-0.1962934285402298,
0.05886619910597801,
-0.231411874294281,
-0.47507742047309875,
0.11514841020107269,
-0.051190439611673355,
0.05599268898367882,
0.36772096157073975,
-0.47165775299072266,
-0.47895216941833496,
-1.4911088943481445,
0.04546736925840378,
-0.5257292985916138,
0.16377107799053192,
-0.23329593241214752,
0.25151243805885315,
-0.12347900122404099,
0.446114182472229,
-0.31331756711006165,
0.6392914056777954,
0.025987153872847557,
-0.42334067821502686,
-0.00466593774035573,
-0.41019102931022644,
0.4165138900279999,
0.07942534238100052,
-0.13011321425437927,
0.05256672203540802,
0.5187205672264099,
0.45181983709335327,
-0.029874805361032486,
-0.28753039240837097,
-0.5894650220870972,
-0.15445677936077118,
-0.08200273662805557,
-0.3821183741092682,
-0.9791818261146545,
0.2862650454044342,
-0.2529139220714569,
-0.21641510725021362,
-0.06621161848306656,
-0.11754617094993591,
-0.05126805230975151,
0.20753149688243866,
-0.10030536353588104,
0.5597451329231262,
0.7050603628158569,
-0.36532890796661377,
0.8418638110160828,
-0.04853067919611931,
-0.4399144649505615,
0.2733394205570221,
-0.567439079284668,
-0.17769083380699158,
-0.007828262634575367,
-0.5973497033119202,
0.11952069401741028,
0.39055004715919495,
0.5135165452957153,
0.48298946022987366,
-0.03169664368033409,
-0.11349088698625565,
0.21707837283611298,
0.2620108127593994,
-0.2959011197090149,
-0.25244736671447754,
0.30123308300971985,
-0.1138852909207344,
-0.38412168622016907,
-0.5847101211547852,
-0.1813594251871109,
-0.7672553062438965,
0.10754664987325668,
0.3227793872356415,
-0.35270434617996216,
0.5206227898597717,
0.38101062178611755,
-0.42527124285697937,
-0.31349411606788635,
0.19955557584762573,
0.29183879494667053,
0.2994452118873596,
-0.18595242500305176,
0.45705994963645935,
0.1959332823753357,
1.200260877609253,
0.2698509395122528,
0.08692095428705215,
0.3861842155456543,
0.10229917615652084,
0.7086352705955505,
0.8401238322257996,
-0.15089932084083557,
-0.05712615326046944,
-0.03503137081861496,
0.7867650389671326,
0.06727559864521027,
-0.048301585018634796,
-0.21915169060230255,
-0.45315656065940857,
-0.004075880162417889,
0.05226857215166092,
-0.19789260625839233,
-0.044707491993904114,
-0.47665277123451233,
-0.38366925716400146,
0.1214323565363884,
-0.0630335733294487,
0.2340579479932785,
-0.31246498227119446,
-0.033264536410570145,
-0.349429190158844,
0.003032163018360734,
0.34065690636634827,
-0.20332710444927216,
-0.026079770177602768,
-0.6283496618270874,
-0.1381434202194214,
0.026829350739717484,
0.7524014115333557,
0.09223433583974838,
0.3135383129119873,
-0.12492434680461884,
0.2014632225036621,
0.52107173204422,
0.17869505286216736,
-0.6560295820236206,
-0.6861944794654846,
-0.0833519920706749,
-0.5768607258796692,
0.27914896607398987,
0.36732539534568787,
0.3478889465332031,
0.17956893146038055,
-0.34679582715034485,
-0.3065268397331238,
0.02469724602997303,
0.06469302624464035,
-0.16267134249210358,
-0.04283887892961502,
0.304717481136322,
0.05680815503001213,
0.5596585869789124,
0.16180476546287537,
-0.6294503808021545,
-0.06272885948419571,
0.17775990068912506,
-0.3106704652309418,
0.1815149188041687,
0.22559420764446259,
0.1927008032798767,
-0.42020848393440247,
-0.035336654633283615,
0.06090226769447327,
-0.2306441068649292,
-0.42613497376441956,
-0.003969748504459858,
-1.232411503791809,
1.1791800260543823,
-0.11438040435314178,
-0.6510114669799805,
1.4895380735397339,
-0.41330212354660034,
0.4257063567638397,
-0.09767162054777145,
-0.09417702257633209,
0.5087430477142334,
-0.031639017164707184,
0.11497246474027634,
-0.04283700883388519,
-0.01684005931019783,
0.06895605474710464,
-0.6061978340148926,
0.6278862953186035,
0.4219607710838318,
0.22422301769256592,
0.1605789214372635,
-0.40382593870162964,
-0.1132710799574852,
0.16911837458610535,
-0.1102442741394043,
0.5092540979385376,
-0.22245509922504425,
0.4865122437477112,
1.1583887338638306,
-0.4433813691139221,
0.4598248302936554,
0.6072238087654114,
-0.02350597083568573,
0.3776203989982605,
0.6977153420448303,
0.271870493888855,
0.8781607747077942,
-0.6654404997825623,
-0.026145856827497482,
-0.32753872871398926,
0.4624282419681549,
-0.7097041606903076,
-0.29312026500701904,
-0.01709236018359661,
0.05155155807733536,
-0.07565609365701675,
0.1927250474691391,
0.3957757353782654,
0.1212955117225647,
0.42258554697036743,
-0.3910740911960602,
0.21710871160030365,
0.03824654966592789,
-0.040916260331869125,
-0.34839877486228943,
-0.014265865087509155,
-0.15109293162822723,
-0.13296246528625488,
0.0662485659122467,
0.4443909823894501,
0.22246034443378448,
-0.6742815971374512,
-0.4084239602088928,
0.2943652272224426,
-0.09679044038057327,
-0.2980884909629822,
0.6352148652076721,
0.7010492086410522,
-0.38653144240379333,
0.06458893418312073,
0.35047829151153564,
0.07185733318328857,
0.2795865535736084,
-0.2619331181049347,
-0.21060703694820404,
-0.6287736296653748,
0.29643192887306213,
0.531910240650177,
0.39327409863471985,
0.027597099542617798,
-0.3681941628456116,
0.24051082134246826,
0.14597393572330475,
-0.8420548439025879,
-0.10893123596906662,
-0.024802612140774727,
-1.0878418684005737,
-0.6969609260559082,
-0.16295279562473297,
0.6183428168296814,
0.6266753077507019,
0.032192349433898926,
-0.047174934297800064,
-0.4682324528694153,
0.2081638127565384,
-0.3804875910282135,
-0.41475966572761536,
-0.18600749969482422,
-0.23395933210849762,
0.15899504721164703,
-0.6234866380691528,
-0.643589437007904,
0.9991194605827332,
0.5756424069404602,
0.1281280368566513,
0.02410695143043995,
0.2602193057537079,
-0.37998977303504944,
-0.21173350512981415,
0.2927064597606659,
0.16969865560531616,
-0.041076865047216415,
0.3579173684120178,
-0.2830069065093994,
-0.45269468426704407,
0.48936590552330017,
-5.948729515075684,
-0.13169842958450317,
-0.5254467725753784,
0.24529390037059784,
-0.5492724776268005,
0.30998703837394714,
0.3809770345687866,
-0.1196209043264389,
0.21002380549907684,
-0.10577426850795746,
0.10206498205661774,
0.16763000190258026,
-0.06292425841093063,
0.5376440286636353,
0.08677096664905548,
0.21880687773227692,
0.21846073865890503,
-0.11719799786806107,
0.05131852254271507,
0.3382534086704254,
-0.1474326103925705,
-0.28632843494415283,
0.06902167946100235,
0.7499608397483826,
0.75594562292099,
0.07863465696573257,
-1.2857506275177002,
0.5086944103240967,
0.09022287279367447,
-0.023915009573101997,
0.11898867785930634,
-0.2868809401988983,
-0.25655487179756165,
-0.6094611883163452,
0.12134729325771332,
0.3446823060512543,
0.6795840859413147,
0.12758567929267883,
0.5229244232177734,
-0.44513607025146484,
0.3652358055114746,
0.5247982144355774,
-0.06945817172527313,
-0.024092528969049454,
0.19385844469070435,
-0.4954347610473633,
-0.29804155230522156,
0.34515780210494995,
0.030218029394745827,
0.5660513639450073,
-0.5574765205383301,
0.2045612335205078,
0.23167160153388977,
-0.1739308387041092,
-0.17327308654785156,
-0.16563542187213898,
0.30035048723220825,
0.27321934700012207,
-0.35365191102027893,
0.2170066237449646,
0.6935469508171082,
-0.5473219156265259,
0.34183552861213684,
-0.7408715486526489,
-0.6235793828964233,
0.03647588938474655,
-0.6282076239585876,
-0.3889678418636322,
0.003540299367159605,
0.03398311510682106,
-0.4348292052745819,
0.49569588899612427,
0.10729165375232697,
-0.6654278039932251,
0.6120323538780212,
-0.27837783098220825,
0.028899235650897026,
0.015507073141634464,
0.3363247811794281,
0.21193024516105652,
-0.0793912336230278,
-0.7632766366004944,
0.08514900505542755,
0.3440678119659424,
-0.04294159263372421,
-0.08970344811677933,
-0.16543984413146973,
-0.019533297047019005,
-0.5720044374465942,
0.12476810067892075,
1.1650896072387695,
-0.42855653166770935,
0.29743558168411255,
0.43843963742256165,
0.33628079295158386,
-0.0009391093044541776,
0.6892898082733154,
-0.5144146680831909,
0.2535568177700043,
0.08573692291975021,
0.602483868598938,
0.07324142754077911,
-0.4946802854537964,
-0.9802567958831787,
-0.046235550194978714,
0.009723663330078125,
-0.574253261089325,
0.46287184953689575,
0.5513840913772583,
-0.5157185196876526,
-0.11842286586761475,
0.21428053081035614,
-0.19273154437541962,
-0.12222914397716522,
0.2807439863681793,
0.5237339735031128,
-0.3464374840259552,
-0.20921845734119415,
0.22577057778835297,
-0.13336960971355438,
0.11210726201534271,
-0.26649752259254456,
-0.07350876182317734,
0.21889451146125793,
0.30299076437950134,
-0.29778388142585754,
0.399169921875,
0.35773369669914246,
-0.5122555494308472,
-0.35179421305656433,
0.021793490275740623,
0.24019449949264526,
-0.3176532983779907,
0.2955089807510376,
0.41717955470085144,
-0.2900012731552124,
-0.005808238405734301,
0.47136566042900085,
0.3238350450992584,
-0.8576882481575012,
0.6597479581832886,
-0.07299646735191345,
-0.1271955966949463,
-0.02791159600019455,
-0.024524271488189697,
0.16451126337051392,
-0.24683749675750732,
0.019238384440541267,
-0.19015979766845703,
0.09406370669603348,
0.028317827731370926,
-0.396260142326355,
0.3241727352142334,
-0.008374740369617939,
-0.3984290659427643,
0.011344710364937782,
0.31294581294059753,
0.2817503809928894,
0.15741349756717682,
-0.21006128191947937,
0.567037045955658,
0.1067688912153244,
-0.9002358317375183,
-0.017157303169369698,
0.3823816180229187,
-0.09204494208097458,
-0.5026169419288635,
0.22124385833740234,
0.051578011363744736,
0.4188162386417389,
0.21750248968601227,
-0.48210805654525757,
0.10410556197166443,
-0.36671146750450134,
0.20142948627471924,
-0.07590752840042114,
-0.08563483506441116,
0.18236945569515228,
0.008381868712604046,
0.0010060694767162204,
0.38953128457069397,
-0.6503596305847168,
0.060095448046922684,
0.46978920698165894,
0.4798303544521332,
0.011484439484775066,
0.22973568737506866,
0.43238964676856995,
-0.40346863865852356,
-0.4564068019390106,
-0.29715287685394287,
0.15385600924491882,
0.6387879848480225,
-0.009698587469756603,
-0.301762193441391,
-0.17136572301387787,
0.4119560122489929,
0.09901462495326996,
-0.49240702390670776,
-0.3551749587059021,
0.19659146666526794,
0.2029801607131958,
-0.41576534509658813,
0.20440317690372467,
-0.02500625140964985,
-0.3928576409816742,
0.10733296722173691,
-0.2766442894935608,
0.01834644004702568,
0.021686315536499023,
-0.5185419321060181,
-0.24136897921562195,
-0.21201565861701965,
-0.5016992688179016,
-0.39736148715019226,
0.10266648977994919,
0.38089194893836975,
0.06326733529567719,
-0.7825368046760559,
0.16253840923309326,
0.0680074617266655,
-0.2480050027370453,
-0.3506337106227875,
-0.05097537115216255,
-0.026043569669127464,
0.3395588994026184,
0.6523327231407166,
-0.002887992188334465,
0.012871017679572105,
-0.19128690659999847,
-0.15828914940357208,
0.22750870883464813,
0.12503467500209808,
0.15893496572971344,
-0.3040228486061096,
-0.43722254037857056,
-0.3483043313026428,
0.46029698848724365,
-0.28630879521369934,
-0.3827589154243469,
0.22599785029888153,
0.49295246601104736,
-0.3554871082305908,
-0.45271122455596924,
0.016027847304940224,
-0.0347849503159523,
0.18046154081821442,
-0.690397322177887,
-0.9312427043914795,
0.00515024596825242,
0.3095545768737793,
-0.28697070479393005,
-0.0010518794879317284,
-0.16202624142169952,
0.30570197105407715,
-0.3407655656337738,
-0.39514899253845215,
-0.2038985639810562,
-0.04105698689818382,
0.1880117505788803,
0.3338453471660614,
-0.5744153261184692,
-0.8927732706069946,
-0.11248406022787094,
0.02860424853861332,
0.054141610860824585,
-0.2407785803079605,
-0.37462282180786133,
0.3797532916069031,
-0.46026208996772766,
-0.06434318423271179,
0.02032638154923916,
-0.2591376006603241,
0.4455164074897766,
0.268085777759552,
-0.38771313428878784,
-0.27451959252357483,
0.11260498315095901,
-0.1444200575351715,
-0.24693480134010315,
-0.5175239443778992,
-0.05196245759725571,
0.4106300473213196,
-0.40741589665412903,
0.23673008382320404,
-0.15007056295871735,
0.40492796897888184,
0.0452561192214489,
-0.10413704067468643,
0.23471100628376007,
-0.5360220670700073,
0.2370118349790573,
-0.48122021555900574,
-0.3503386676311493,
-0.5269095301628113,
-0.12365435808897018,
0.091534823179245,
0.31635236740112305,
0.11619722843170166,
-0.13014742732048035,
0.1552133560180664,
0.3482789993286133,
0.6034930348396301,
-0.3326878547668457,
0.13632965087890625,
0.32663625478744507,
0.1128353700041771,
0.3630199134349823,
-0.1211634948849678,
0.3610480725765228,
0.22303728759288788,
-0.17603543400764465,
0.3652304708957672,
0.5750734210014343,
-0.4185388386249542,
0.23020286858081818,
-0.1801699995994568,
-0.7827739715576172,
0.7667533755302429,
0.056799110025167465,
-0.1575814038515091,
0.0037743709981441498,
0.5471984148025513,
-0.2445850968360901,
-0.911063015460968,
0.5599639415740967,
-0.27876633405685425,
0.22418484091758728,
-0.13157977163791656,
-0.055023595690727234,
0.4113428294658661,
0.7639155387878418,
-0.229551762342453,
-0.2482139766216278,
-0.1302793025970459,
-0.026371629908680916,
0.5926815271377563,
-0.23209908604621887,
0.2636599540710449,
0.16620057821273804,
0.5482348799705505,
0.3874032497406006,
-0.4912629723548889,
-0.05315519496798515,
-0.21645885705947876,
0.47448810935020447,
0.13298778235912323,
0.2742379307746887,
-0.42457959055900574,
0.5801302790641785,
0.3459153473377228,
-0.012103935703635216,
-0.08513232320547104,
-0.20818251371383667,
-0.24081368744373322,
-0.16035586595535278,
0.19160810112953186,
-0.4141553044319153,
0.18572168052196503,
0.6016822457313538,
0.37446320056915283,
0.8496976494789124,
-0.08060085773468018,
-0.21935774385929108,
-0.4853176772594452,
0.3798043429851532,
0.9645031094551086,
-0.004894869402050972,
0.1905701607465744,
-0.14214769005775452,
-0.3394804000854492,
0.20661954581737518,
-0.6737471222877502,
0.030548105016350746,
-0.14835508167743683,
-0.08632004261016846,
0.47873520851135254,
0.05758209154009819,
-0.11423499137163162,
0.19449906051158905,
0.14798258244991302,
-0.06347079575061798,
-0.596671998500824,
-0.4653787314891815,
-0.04733487218618393,
-0.3005363643169403,
0.21195088326931,
0.34010496735572815,
-0.024685826152563095,
-0.2185630351305008,
-0.4801582992076874,
-0.5777397155761719,
0.3338722884654999,
0.16574843227863312,
-0.06311100721359253,
-0.09716635197401047,
-0.6289352178573608,
1.0110191106796265,
0.15175318717956543,
0.13534875214099884,
-0.18789418041706085,
-0.19653275609016418,
0.3056999444961548,
0.27459728717803955,
-0.249440535902977,
0.14238008856773376,
-0.530543327331543,
-0.3279753029346466,
-0.5033959746360779,
0.15226499736309052,
0.5038979053497314,
0.18655240535736084,
-0.20493537187576294,
-0.08781377971172333,
0.3308241367340088,
0.17265860736370087,
0.13771289587020874,
-0.3483179211616516,
-0.16163526475429535,
0.2442072182893753,
-0.16934865713119507,
-0.126922145485878,
0.5752005577087402,
-0.01704218238592148,
-0.10894238203763962,
-0.01050532516092062,
0.03490466624498367,
0.3326060473918915,
-0.26986226439476013,
0.0961775928735733,
-0.12496920675039291,
-0.2230043113231659,
-0.6811932325363159,
0.688639223575592,
-0.7148638963699341,
0.12108727544546127,
-0.1845354586839676,
0.007776977960020304,
0.3574085533618927,
-0.29569974541664124,
-0.360847145318985,
0.30587533116340637,
-0.17118403315544128,
0.5728300213813782,
-0.16907699406147003,
0.8276246786117554,
-0.22111214697360992,
-0.24088263511657715,
-0.6368070244789124,
0.698242723941803,
0.02324194647371769,
0.4265933632850647,
0.09092078357934952,
-0.08644696325063705,
-0.3851495683193207,
0.44785988330841064,
0.23070122301578522,
-0.9646323323249817,
-0.028302572667598724,
-0.10667416453361511
] |
" The Mouse Brain in Stereotaxic Coordinates" is the most widely used and cited atlas of the mouse brain in print. It provides researchers and students with both accurate stereotaxic coordinates for laboratory use, and detailed delineations and indexing of structures for reference. The accompanying DVD provides drawings of brains structures that can be used as templates for making figures for publication. The 3rd edition is both a major revision and an expansion of previous editions. Delineations and photographs in the horizontal plane of section now complement the coronal and sagittal series, and all the tissue sections are now shown in high resolution digital color photography. The photographs of the sections and the intermediate sections are also provided on the accompanying DVD in high-resolution JP 2000 format. The delineations of structures have been revised, and naming conventions made consistent with Paxinos and Watson's "Rat Brain in Stereotaxic Coordinates, 6th Edition". The 3rd edition of this atlas is now in more practical 14"x11" format for convenient lab use. This edition is in full color throughout. It includes a CD of all plates and diagrams, as well as Adobe Illustrator files of the diagrams, and a variety of additional useful material. Coronal and sagittal diagrams are completely reworked and updated. Rhombomeric borders are included in sagittal figures, for the first time in mammals. Microscopic plates are scanned with a new method in much higher quality. | [
-0.005326851271092892,
0.0006271261954680085,
-0.019878024235367775,
0.014082739129662514,
0.03093837760388851,
-0.017899779602885246,
0.010142307728528976,
-0.009774583391845226,
-0.01890561729669571,
-0.02340208739042282,
-0.011419657617807388,
0.0023029292933642864,
-0.01988202892243862,
0.007135071791708469,
-0.009232744574546814,
0.026176244020462036,
-0.04275908321142197,
0.012480450794100761,
0.017285548150539398,
-0.0015889229252934456,
-0.0002607059432193637,
-0.004379702266305685,
0.01022074744105339,
0.047444507479667664,
0.019940577447414398,
-0.034664466977119446,
-0.004625325091183186,
-0.001942565431818366,
0.0224506463855505,
0.02040020003914833,
0.007628359831869602,
0.017071673646569252,
0.004214090295135975,
0.0007673148065805435,
-0.002834874205291271,
-0.000545053742825985,
-0.00978358369320631,
0.02409457042813301,
0.017832372337579727,
-0.003987384960055351,
-0.016090266406536102,
-0.0055430252104997635,
0.008294055238366127,
0.004595569334924221,
-0.008935154415667057,
-0.028216863051056862,
-0.0021053352393209934,
0.0038629844784736633,
-0.002084750449284911,
0.0031752504874020815,
-0.017120594158768654,
0.005692048463970423,
-0.01357094943523407,
0.0243498757481575,
-0.006472373381257057,
-0.02264934778213501,
0.019558478146791458,
0.003485589288175106,
0.012366637587547302,
0.022856812924146652,
-0.0014932448975741863,
0.05443643033504486,
0.0011773834703490138,
0.0376700684428215,
0.004257601220160723,
-0.06692519783973694,
0.007743204012513161,
0.03939186781644821,
-0.0016151696909219027,
0.01032697968184948,
0.010569073259830475,
0.015245217829942703,
0.010267041623592377,
0.004957305267453194,
-0.011525513604283333,
0.01607535406947136,
-0.023883536458015442,
0.006739248521625996,
-0.0015384359285235405,
-0.02185550145804882,
0.024721845984458923,
-0.03698156401515007,
0.010446938686072826,
0.023132475093007088,
0.008730826899409294,
0.0037391872610896826,
-0.03812567889690399,
0.002794599160552025,
0.041700899600982666,
0.0204449649900198,
-0.0019971346482634544,
0.008811743929982185,
-0.02929220348596573,
-0.014391111209988594,
0.008700521662831306,
-0.010542446747422218,
0.004453427158296108,
-0.0013653058558702469,
0.018124401569366455,
-0.0020964406430721283,
-0.014359485357999802,
0.013294692151248455,
0.02743695303797722,
-0.029470227658748627,
-0.007579183205962181,
0.022616110742092133,
-0.007055195979773998,
0.008768200874328613,
-0.014044057577848434,
0.006579662207514048,
-0.004536837805062532,
0.026578320190310478,
-0.0345754399895668,
-0.026844952255487442,
-0.000867326045408845,
-0.012468094006180763,
0.012078044936060905,
-0.018962612375617027,
0.009752838872373104,
-0.025955334305763245,
0.0007008598186075687,
-0.03384274244308472,
0.005525578279048204,
0.0073803868144750595,
0.009900949895381927,
-0.007675706874579191,
0.0002339655184186995,
0.011492142453789711,
-0.00793599896132946,
0.003097012871876359,
-0.008440205827355385,
0.0052673546597361565,
0.015472209081053734,
0.030816353857517242,
0.01300826296210289,
-0.006804902572184801,
-0.03417813777923584,
-0.0013163811527192593,
0.013256235048174858,
-0.013441707007586956,
0.019641228020191193,
0.011616228148341179,
0.008397446013987064,
0.004837327636778355,
0.036236606538295746,
-0.009027568623423576,
0.01609748601913452,
-0.0033332332968711853,
-0.006002710200846195,
-0.012746928259730339,
0.01312596071511507,
-0.00682264007627964,
0.003525935346260667,
-0.019386734813451767,
-0.003030913881957531,
-0.007688499987125397,
-0.004775021690875292,
0.020740848034620285,
-0.01422547921538353,
-0.005601990036666393,
-0.016835154965519905,
-0.0013526719994843006,
0.009505382739007473,
0.009823083877563477,
-0.0072894226759672165,
0.014775421470403671,
0.0045396713539958,
-0.0019059679470956326,
-0.024183988571166992,
0.0028359622228890657,
-0.011148491874337196,
-0.029018834233283997,
-0.014800474047660828,
0.00607724767178297,
-0.03878696635365486,
0.008612374775111675,
0.03128870949149132,
0.008582129143178463,
-0.012940464541316032,
0.06679405272006989,
-0.011560562998056412,
0.04073968902230263,
-0.011448873206973076,
0.00986926443874836,
-0.0009398944675922394,
-0.002026174683123827,
-0.04409169405698776,
-0.003646180033683777,
-0.00015529384836554527,
-0.0356946736574173,
-0.013139527291059494,
-0.0034559988416731358,
0.004940961021929979,
-0.0012439040001481771,
-0.02215973287820816,
0.0038939877413213253,
0.00573111604899168,
0.0003733017947524786,
0.017759282141923904,
0.0063340067863464355,
0.01579718291759491,
-0.022772368043661118,
0.015771817415952682,
-0.01931576244533062,
0.03464874252676964,
-0.014196961186826229,
0.033888015896081924,
-0.03669711947441101,
-0.019551588222384453,
-0.012247179634869099,
0.023183036595582962,
-0.01338665746152401,
-0.01664845645427704,
-0.0055452631786465645,
-0.001540852477774024,
0.01255844347178936,
0.0053192125633358955,
-0.01727946102619171,
0.0028292115312069654,
-0.016653206199407578,
-0.004232498817145824,
-0.02351655811071396,
0.01104939728975296,
-0.023465273901820183,
0.0027387095615267754,
-0.005370763596147299,
0.00648491783067584,
0.014114255085587502,
-0.014336500316858292,
-0.007265731226652861,
-0.012706134468317032,
0.025785235688090324,
-0.011592546477913857,
-0.00564963836222887,
0.024957284331321716,
-0.02627413533627987,
0.010695572942495346,
-0.007878825068473816,
0.007131802849471569,
-0.0052683474496006966,
-0.01987309753894806,
-0.03440083563327789,
0.0041544195264577866,
0.0036550248041749,
-0.03108503855764866,
0.011879857629537582,
0.008004927076399326,
-0.0006768014281988144,
0.005333576817065477,
-0.00438288040459156,
0.003926479257643223,
0.0020360667258501053,
0.0007701688446104527,
0.02538537234067917,
-0.03316691517829895,
0.015919750556349754,
-0.006348867900669575,
-0.008434358984231949,
0.022425906732678413,
-0.0030464911833405495,
0.0005489513860084116,
0.0037036449648439884,
0.011924363672733307,
0.019085373729467392,
-0.020761188119649887,
-0.00806032307446003,
0.029278753325343132,
0.016747862100601196,
0.021124310791492462,
-0.012509340420365334,
0.004250556230545044,
-0.014100845903158188,
0.002578131854534149,
-0.08086593449115753,
-0.009336574003100395,
0.01156381145119667,
0.030268430709838867,
0.016477081924676895,
-0.017010007053613663,
-0.00012167124077677727,
0.012062691152095795,
-0.0005131103098392487,
-0.001081986934877932,
0.003608278464525938,
0.011046797968447208,
-0.01416703499853611,
0.0004026982933282852,
-0.03494657203555107,
-0.012968011200428009,
0.025684501975774765,
-0.014523090794682503,
0.008204720914363861,
0.011830607429146767,
0.030670171603560448,
-0.03430992737412453,
-0.04206771031022072,
0.01899189129471779,
0.007294332608580589,
-0.029786400496959686,
0.027707234025001526,
0.007662211544811726,
-0.015070518478751183,
0.0029487833380699158,
0.0007359718438237906,
0.007647148333489895,
0.0006312117911875248,
-0.0252099446952343,
0.008842019364237785,
0.0002914650831371546,
-0.017628664150834084,
0.003448640927672386,
-0.0011605144245550036,
-0.01669115014374256,
0.003568941494449973,
0.002848542295396328,
0.00488579785451293,
-0.007725867442786694,
0.0029534834902733564,
-0.009932420216500759,
0.038370534777641296,
0.03405987471342087,
0.021772397682070732,
-0.01662934571504593,
0.0164241474121809,
-0.008459357544779778,
-0.009371967986226082,
0.01751640811562538,
-0.014468925073742867,
0.0066271331161260605,
-0.030898675322532654,
-0.01602405495941639,
-0.011284798383712769,
0.007586746942251921,
-0.04583725705742836,
0.00147854327224195,
0.007245559711009264,
0.014276762492954731,
0.014086036011576653,
0.007281444501131773,
0.008016372099518776,
-0.015088444575667381,
-0.0038010329008102417,
-0.007695609703660011,
0.005844048224389553,
0.0023209117352962494,
-0.024747224524617195,
-0.0024874655064195395,
-0.03667503222823143,
-0.013529262505471706,
-0.011781491339206696,
-0.0005777288461104035,
-0.013360346667468548,
-0.0017756226006895304,
0.018247384577989578,
0.01597008854150772,
-0.016795028001070023,
-0.015097447670996189,
-0.0029256686102598906,
0.011154275387525558,
0.012301039882004261,
0.021581575274467468,
0.001150644151493907,
-0.016716519370675087,
0.00277148000895977,
0.017983676865696907,
0.004422261379659176,
0.006386356893926859,
-0.020176995545625687,
0.007791416719555855,
0.027541441842913628,
0.005847185850143433,
0.00534710893407464,
0.011361333541572094,
0.010504547506570816,
0.007066099438816309,
0.0013827185612171888,
-0.010848652571439743,
-0.005475349724292755,
0.01903722621500492,
-0.001826359424740076,
-0.005642826668918133,
0.013221600092947483,
-0.004736799746751785,
0.001180178951472044,
-0.010492022149264812,
-0.015966076403856277,
0.017238831147551537,
0.005548759363591671,
0.010156020522117615,
-0.025170013308525085,
-0.010477305389940739,
0.07226736843585968,
0.00520508224144578,
0.018276376649737358,
-0.02657533437013626,
0.02259540930390358,
-0.013352753594517708,
-0.023676831275224686,
0.007305034901946783,
-0.010139026679098606,
0.010124418884515762,
0.010768432170152664,
-0.019959276542067528,
0.005408056546002626,
0.0026421095244586468,
-0.005174712277948856,
-0.0010296022519469261,
0.03235159069299698,
-0.000909584341570735,
0.0050947582349181175,
-0.014835144393146038,
-0.008102914318442345,
-0.00975829642266035,
-0.014118509367108345,
-0.013224507682025433,
-0.016649801284074783,
-0.01262994296848774,
0.0023624442983418703,
-0.019164830446243286,
-0.004658038727939129,
0.007362368516623974,
0.016589559614658356,
0.04267450422048569,
-0.006446351297199726,
0.014383265748620033,
-0.0030258838087320328,
0.00814132671803236,
0.010366111062467098,
-0.04090222716331482,
-0.005840976722538471,
-0.005133131053298712,
-0.0002350697759538889,
-0.019001927226781845,
0.013370100408792496,
0.019094068557024002,
0.015742219984531403,
-0.022874854505062103,
0.019894976168870926,
-0.0028673899360001087,
0.0018997269216924906,
0.016372941434383392,
0.0007885631639510393,
-0.0064239054918289185,
0.01216797437518835,
0.007546527311205864,
0.03074878826737404,
-0.021176140755414963,
0.01045598741620779,
0.00016779208090156317,
0.0004989909939467907,
-0.01874886453151703,
-0.012533951550722122,
0.00826549157500267,
0.006607969291508198,
-0.0019298074766993523,
0.01620347425341606,
-0.016101043671369553,
-0.041322506964206696,
-0.00025845388881862164,
-0.0246637724339962,
-0.0022601173259317875,
0.004756376147270203,
-0.02422212064266205,
-0.00825735367834568,
0.0196247361600399,
-0.031379859894514084,
-0.01762864552438259,
-0.0075034089386463165,
-0.022356107831001282,
-0.0006452039815485477,
0.022506386041641235,
-0.022717703133821487,
-0.02196628227829933,
-0.001170637086033821,
-0.012654242105782032,
0.0004429314285516739,
0.001988142728805542,
0.03081798553466797,
-0.07391027361154556,
0.008970819413661957,
0.008367957547307014,
-0.0006358610116876662,
-0.010108167305588722,
-0.0036635040305554867,
0.0022962591610848904,
0.006716805510222912,
0.02728952094912529,
0.0029408750124275684,
-0.0017849784344434738,
-0.03670899569988251,
-0.010389311239123344,
-0.016783196479082108,
0.007648534141480923,
-0.008039651438593864,
-0.002430056920275092,
0.006257097236812115,
-0.002565352711826563,
-0.005505676381289959,
-0.010764695703983307,
0.0468895398080349,
-0.013075090944766998,
0.0075311725959181786,
-0.010397832840681076,
-0.0810481384396553,
-0.016084518283605576,
0.015640130266547203,
0.02622848004102707,
-0.007462670560926199,
-0.020216170698404312,
-0.0031988208647817373,
-0.017266612499952316,
0.030765634030103683,
-0.016520893201231956,
-0.006752301007509232,
0.009208197705447674,
0.013227811083197594,
0.002219991758465767,
-0.0006029263604432344,
-0.006305343937128782,
0.018592800945043564,
-0.033750273287296295,
-0.026364928111433983,
0.008651530370116234,
0.006613956764340401,
-0.01449478417634964,
-0.012769957073032856,
-0.007480636704713106,
-0.004747465252876282,
0.0105197224766016,
0.01465400867164135,
0.01928633451461792,
-0.008742013946175575,
-0.006965154781937599,
-0.009451603516936302,
0.02355358377099037,
0.0009846333414316177,
-0.03788731247186661,
-0.03666074946522713,
-0.018178369849920273,
-0.009648984298110008,
0.007399922702461481,
-0.03642657399177551,
-0.002381842117756605,
-0.006451986264437437,
0.00416925735771656,
0.00522580137476325,
-0.009665566496551037,
-0.02658185549080372,
-0.006338235456496477,
0.004712938331067562,
0.010575227439403534,
0.00720315333455801,
-0.012633973732590675,
0.01170877180993557,
-0.030656203627586365,
-0.018194042146205902,
0.017227286472916603,
0.01138293743133545,
0.015103653073310852,
0.004962150938808918,
-0.002971523441374302,
0.007097162306308746,
0.016501856967806816,
0.007281227968633175,
-0.0016777615528553724,
-0.012756584212183952,
0.07190877199172974,
-0.010157017968595028,
-0.0024357002694159746,
-0.018390271812677383,
-0.0019413377158343792,
0.0010222066193819046,
0.008731350302696228,
-0.0022444254718720913,
-0.0061637829057872295,
0.006858532316982746,
-0.02969059906899929,
-0.01915842667222023,
-0.018425066024065018,
0.010984283871948719,
-0.0072405473329126835,
-0.022816594690084457,
-0.02084643766283989,
0.02699173241853714,
0.008322328329086304,
-0.0021273461170494556,
-0.004242431838065386,
-0.007011559326201677,
-0.055360276252031326,
0.0090049859136343,
0.004441757686436176,
-0.005925211124122143,
-0.004092805087566376,
-0.003503711661323905,
-0.001191468327306211,
-0.0022963942028582096,
-0.00042814225889742374,
0.0012750846799463034,
0.008832432329654694,
0.01550860982388258,
0.012144595384597778,
0.013920365832746029,
0.02089705690741539,
0.0055526252835989,
-0.020803052932024002,
-0.00404543848708272,
-0.018919890746474266,
0.011213649995625019,
0.008787211030721664,
0.027914591133594513,
0.0006954411510378122,
0.027083933353424072,
0.013307791203260422,
-0.021788055077195168,
0.03176618367433548,
0.002626048168167472,
0.0277539249509573,
0.0064924415200948715,
0.014104794710874557,
-0.009229236282408237,
0.0016664331778883934,
-0.0015860914718359709,
-0.019495051354169846,
0.017620598897337914,
-0.01171126775443554,
-0.0008578539127483964,
0.02175254002213478,
-0.013918987475335598,
-0.0205485038459301,
-0.00837808195501566,
0.02577189728617668,
0.026997987180948257,
0.012700823135674,
-0.004973715171217918,
0.030539769679307938,
0.016760671511292458,
-0.0005788434064015746,
0.014298241585493088,
0.0053821466863155365,
0.026514554396271706,
0.0026361066848039627,
0.008806207217276096,
-0.015294386073946953,
-0.006300770677626133,
0.015227967873215675,
-0.010571112856268883,
-0.008329778909683228,
-0.002752412110567093,
0.0017335116863250732,
-0.022909358143806458,
0.0028609761502593756,
-0.010011112317442894,
-0.014258884824812412,
0.008811801671981812,
0.0024035004898905754,
0.014018118381500244,
0.007488729897886515,
0.020758477970957756,
0.008725353516638279,
0.012475565075874329,
0.011360673233866692,
0.033038705587387085,
0.02144097350537777,
0.004549461416900158,
0.003322661854326725,
-0.013462193310260773,
0.0074672033078968525,
0.05570665001869202,
0.03192831575870514,
-0.03355012834072113,
-0.011594980955123901,
-0.007451364770531654,
-0.05330447480082512,
0.02943405881524086,
-0.016079874709248543,
-0.0075286999344825745,
0.008695308119058609,
-0.003493787022307515,
-0.00480670714750886,
-0.006357189267873764,
-0.024517349898815155,
-0.008063364773988724,
-0.0060451943427324295,
0.03060930408537388,
0.038994766771793365,
-0.008531207218766212,
0.012299174442887306,
-0.021571392193436623,
0.029742449522018433,
0.032353296875953674,
0.025042470544576645,
-0.03821726143360138,
-0.0018152929842472076,
0.01141713559627533,
0.012896783649921417,
-0.017418812960386276,
0.021617239341139793,
0.01308402419090271,
0.0007599462405778468,
-0.013429613783955574,
0.009121615439653397,
0.06230451539158821,
-0.00033902376890182495,
-0.01235440094023943,
0.025441348552703857,
0.006608283147215843,
0.0001532293390482664,
-0.014794171787798405,
-0.005610231775790453,
-0.011573824100196362,
0.008747749961912632,
-0.003293545451015234,
0.014174038544297218,
0.0190363060683012,
-0.0046178726479411125,
-0.006131399888545275,
0.007374865934252739,
0.008242066018283367,
-0.0037935790605843067,
-0.012674849480390549,
-0.033813219517469406,
0.012159994803369045,
0.014029692858457565,
-0.0014804790262132883,
-0.021490460261702538,
0.008819704875349998,
0.01510525681078434,
0.02921449765563011,
0.01898103579878807,
0.0053920987993478775,
-0.01699647679924965,
0.003610074520111084,
-0.015238909982144833,
0.012641111388802528,
-0.006915154401212931,
-0.012441529892385006,
0.015223825350403786,
0.024051569402217865,
-0.01693311519920826,
0.022199619561433792,
-0.014266492798924446,
-0.020257897675037384,
-0.002343219006434083,
0.0019285749876871705,
0.006875116378068924,
0.00498157599940896,
-0.005595969967544079,
0.009702195413410664,
-0.016937291249632835,
-0.012974534183740616,
0.008087290450930595,
0.025530656799674034,
-0.025363793596625328,
-0.008157906122505665,
0.019370269030332565,
-0.022228579968214035,
-0.021006297320127487,
-0.009488788433372974,
-0.01563766598701477,
-0.004303005989640951,
-0.020611604675650597,
0.006798478774726391,
-0.0038360590115189552,
0.004541110247373581,
0.0062660216353833675,
-0.012523356825113297,
-0.023882433772087097,
-0.013044111430644989
] | [
0.04538106918334961,
0.09948340803384781,
0.05041702091693878,
-0.15491560101509094,
0.07880377769470215,
0.2068173885345459,
-0.29484352469444275,
0.13732542097568512,
0.15485085546970367,
-0.38904958963394165,
-0.4346093237400055,
0.374925822019577,
-0.16369295120239258,
-0.1903168112039566,
-0.27750664949417114,
0.35385629534721375,
0.7939207553863525,
-0.1641796976327896,
-0.5446542501449585,
-0.3074629604816437,
0.028896205127239227,
-0.4987923800945282,
0.2866579294204712,
-0.3452293872833252,
-0.18175484240055084,
0.10037833452224731,
0.7252455949783325,
0.13597360253334045,
-0.3806401789188385,
0.0581587478518486,
-0.467430055141449,
0.2811007499694824,
-0.14585955440998077,
-0.4245114028453827,
0.10914508253335953,
0.4094809591770172,
-0.13240936398506165,
-0.28144896030426025,
-0.005943857599049807,
0.041282493621110916,
0.5504857897758484,
0.3005874454975128,
-0.37404143810272217,
0.8547775745391846,
-0.4938933849334717,
0.19504019618034363,
-1.5258156061172485,
0.2292426973581314,
-0.47234418988227844,
0.38312625885009766,
-0.44002270698547363,
0.2539767026901245,
0.38982173800468445,
0.5243711471557617,
-0.30588120222091675,
0.11537265032529831,
-0.4223117530345917,
-0.03135538101196289,
0.016855919733643532,
-0.13073976337909698,
0.2619090676307678,
0.49902597069740295,
-0.014974371530115604,
0.2730858623981476,
0.05101684480905533,
-0.30740460753440857,
0.07673920691013336,
0.09742368757724762,
-0.2548562288284302,
0.006245065946131945,
0.29710623621940613,
0.24846117198467255,
-0.5790020823478699,
0.013172692619264126,
-0.26164448261260986,
0.39010924100875854,
0.11506679654121399,
-0.17180563509464264,
0.582871675491333,
-0.17327825725078583,
0.2582683861255646,
-0.12775209546089172,
0.6807010769844055,
-0.43702441453933716,
0.3183349072933197,
0.1438070833683014,
-0.4592783749103546,
0.2344263195991516,
-0.29787275195121765,
-0.3808859586715698,
-0.04906442016363144,
-0.6840286254882812,
-0.177231565117836,
0.5242183208465576,
0.6300472617149353,
0.16419874131679535,
0.4730303883552551,
0.12968750298023224,
0.06233503296971321,
-0.33731546998023987,
-0.1761246919631958,
0.4122583568096161,
0.39270588755607605,
-0.09590324014425278,
-0.3443712890148163,
-0.5888174176216125,
-0.07303372770547867,
-0.4764418303966522,
0.09015140682458878,
0.5589458346366882,
-0.6747172474861145,
0.10190773010253906,
0.10749071091413498,
-0.6320139765739441,
-0.1984613686800003,
0.08741244673728943,
0.23696520924568176,
0.13805826008319855,
-0.41876357793807983,
0.5626053214073181,
-0.2185007929801941,
0.8845739364624023,
-0.036648787558078766,
-0.12555049359798431,
0.5042015314102173,
-0.040014542639255524,
0.33939245343208313,
0.2668784260749817,
-0.2044460028409958,
-0.0947490856051445,
-0.035097938030958176,
0.32923468947410583,
0.2659201920032501,
-0.18943768739700317,
0.09684640914201736,
0.010441373102366924,
0.4427529573440552,
-0.36696118116378784,
0.45177802443504333,
0.5245552659034729,
0.21054160594940186,
-0.5013075470924377,
-0.9739623069763184,
-0.14837920665740967,
0.2042125016450882,
-0.5280848145484924,
-0.045743945986032486,
-0.020194752141833305,
-0.7794029712677002,
-0.15773630142211914,
0.35379254817962646,
0.17405426502227783,
-0.1665327399969101,
-0.8379076719284058,
-0.011322579346597195,
0.828087329864502,
-0.09298048168420792,
-0.06531435996294022,
-0.3676762878894806,
-0.5363405346870422,
0.6310300230979919,
-0.4926038086414337,
-0.36037224531173706,
-0.268187552690506,
-0.10175652801990509,
-0.44374459981918335,
0.3367588520050049,
0.2857883870601654,
-0.18934942781925201,
-0.16877569258213043,
0.30643537640571594,
-0.4187852740287781,
0.6906023621559143,
0.07793501764535904,
-0.4230511784553528,
0.46376585960388184,
0.8736116886138916,
0.6627344489097595,
0.8042376041412354,
-0.3886229693889618,
-0.6020808815956116,
-0.4164220094680786,
0.37598422169685364,
-0.6165577173233032,
0.5650297403335571,
0.2917095422744751,
0.7310711145401001,
0.12758857011795044,
0.10376335680484772,
0.032305117696523666,
-0.1883019357919693,
-0.8666098117828369,
0.38046786189079285,
-0.6717826724052429,
1.0330424308776855,
-0.21489131450653076,
-0.49464303255081177,
0.4687415361404419,
-0.06957656890153885,
0.10238125920295715,
-0.5218809247016907,
0.40596821904182434,
0.25294750928878784,
0.13967756927013397,
-0.21111835539340973,
-0.3325473666191101,
-0.09370721131563187,
-0.37300774455070496,
0.3861503303050995,
0.06731961667537689,
0.3507169485092163,
-0.29946497082710266,
-0.15922138094902039,
0.12347422540187836,
0.4543516933917999,
-0.13541357219219208,
-0.01646130345761776,
0.1824932098388672,
-0.10928618907928467,
-0.1168193519115448,
0.9189754724502563,
0.07118097692728043,
0.02277117222547531,
-0.14378976821899414,
-0.3689301609992981,
0.7610455751419067,
0.38071703910827637,
0.5625297427177429,
0.8139352798461914,
-0.46452564001083374,
-0.33048388361930847,
-0.19733282923698425,
0.541347086429596,
-0.3578121066093445,
-0.290387898683548,
-0.22414368391036987,
0.2988453507423401,
-0.2678009569644928,
0.5590704083442688,
-0.29053133726119995,
0.12003961950540543,
-0.2810841500759125,
-0.37324610352516174,
0.15810838341712952,
-0.1275019645690918,
-0.14431624114513397,
0.16364218294620514,
0.2923762798309326,
-0.34540554881095886,
-0.17626860737800598,
0.25889402627944946,
0.3492211103439331,
0.018325500190258026,
-0.37823647260665894,
0.14797690510749817,
0.29811891913414,
0.0642741248011589,
-0.8073332905769348,
0.28651702404022217,
0.3261060416698456,
-0.030522724613547325,
-0.031391434371471405,
-0.33223721385002136,
0.411454975605011,
-0.41311007738113403,
-1.0540651082992554,
0.009489834308624268,
-0.057592786848545074,
0.40108516812324524,
0.3385941982269287,
0.12529800832271576,
0.3700256049633026,
-0.3086942732334137,
0.5191053748130798,
0.13348016142845154,
-0.290849506855011,
0.06742041558027267,
-0.03391818702220917,
-0.309552401304245,
-0.4357224404811859,
0.37610501050949097,
0.563906729221344,
0.6235696077346802,
0.28449922800064087,
-0.29829394817352295,
-0.25965648889541626,
0.29473796486854553,
-0.6658706068992615,
0.02365584298968315,
0.09880063682794571,
-0.4769202172756195,
0.537365734577179,
0.008481614291667938,
-0.5723208785057068,
-0.364899605512619,
0.6352587342262268,
-0.24440810084342957,
0.07280061393976212,
-0.0977104902267456,
-0.11560370028018951,
-0.18249115347862244,
0.051823560148477554,
-0.051056236028671265,
-0.02996065653860569,
0.1625853180885315,
0.13228291273117065,
-0.5992939472198486,
0.3644004166126251,
-5.908474922180176,
0.3676380515098572,
-0.559307336807251,
-0.19056569039821625,
-0.29859063029289246,
-0.35753333568573,
0.16366170346736908,
-0.07778231799602509,
-0.06343886256217957,
-0.30037790536880493,
0.03511194512248039,
0.10891908407211304,
-0.0011610614601522684,
0.8721339106559753,
0.010762635618448257,
0.14364978671073914,
-0.10905225574970245,
-0.1708505004644394,
0.21952581405639648,
0.45195022225379944,
0.2907107472419739,
-0.5169248580932617,
0.213228240609169,
0.4703662395477295,
0.3723209500312805,
1.1177549362182617,
-0.6871263980865479,
-0.04640330746769905,
-0.19992811977863312,
-0.6886779069900513,
-0.18733589351177216,
-0.6950382590293884,
-0.47364872694015503,
0.47472745180130005,
0.05104006826877594,
0.2426031231880188,
0.002050478709861636,
-0.13749319314956665,
0.584448516368866,
-0.4347893297672272,
0.2869255244731903,
0.579336404800415,
-0.03893936797976494,
-0.5309441089630127,
0.408713698387146,
-0.4160550832748413,
-0.2743483781814575,
0.2650330066680908,
-0.2190995067358017,
0.7140819430351257,
0.07320962101221085,
-0.19315145909786224,
-0.23820719122886658,
-0.01344469003379345,
0.10148663073778152,
-0.5556582808494568,
0.775902271270752,
0.127809077501297,
0.09874498844146729,
-0.1921185553073883,
0.32774174213409424,
-0.4438494145870209,
-0.618255078792572,
-0.8999829888343811,
-0.5521027445793152,
0.1011880487203598,
-0.4618528187274933,
-0.35132747888565063,
0.14053894579410553,
0.2634580731391907,
-0.12757191061973572,
0.32278570532798767,
-0.22034819424152374,
-0.7017560601234436,
0.4969196915626526,
0.22071479260921478,
0.05171507969498634,
-0.17822356522083282,
-0.11077671498060226,
0.030507974326610565,
-0.42083609104156494,
-0.34286487102508545,
0.2577952742576599,
0.130771204829216,
-0.4109785258769989,
-0.7034229040145874,
-0.31556078791618347,
0.23424436151981354,
-0.3699571490287781,
-0.19857366383075714,
0.9033268094062805,
-0.8146143555641174,
-0.22708269953727722,
0.39081820845603943,
0.18958108127117157,
-0.39836931228637695,
0.8715139627456665,
0.34842315316200256,
0.7200902104377747,
-0.18154507875442505,
0.5586938261985779,
0.02424677647650242,
-0.006823876406997442,
-0.45389607548713684,
-0.22048860788345337,
-0.05152200907468796,
-0.5780138969421387,
0.17865796387195587,
0.748937726020813,
-0.2537519037723541,
-0.2931913733482361,
-0.22883696854114532,
0.30581313371658325,
-0.06909272074699402,
0.7042680382728577,
-0.3189123570919037,
0.07120367139577866,
-0.16302929818630219,
0.32633769512176514,
-0.7042415738105774,
-0.15469355881214142,
-0.6278737783432007,
-0.44500094652175903,
0.4494934380054474,
-0.32573401927948,
0.23545865714550018,
-0.058225277811288834,
0.7430553436279297,
-0.7214136123657227,
0.08808987587690353,
0.23652368783950806,
0.34343984723091125,
0.2478461116552353,
0.1936626136302948,
0.4188483953475952,
-0.5851441621780396,
-0.10457643866539001,
0.13656707108020782,
0.12365247309207916,
-0.4248199164867401,
0.45668119192123413,
0.26131874322891235,
-0.056528422981500626,
-0.22610101103782654,
-0.12869957089424133,
-0.19680391252040863,
-0.26138728857040405,
-0.061717115342617035,
0.004076096694916487,
0.11587467789649963,
0.41082048416137695,
-0.24229241907596588,
0.1659688502550125,
0.19668550789356232,
0.18925558030605316,
0.12760747969150543,
-0.3877604007720947,
0.27814245223999023,
-0.19958582520484924,
-0.06210233271121979,
0.29934990406036377,
0.06940173357725143,
-0.5397471189498901,
-0.025589799508452415,
0.3020203411579132,
-0.008971590548753738,
0.27603381872177124,
-0.39329081773757935,
-0.30646708607673645,
0.19591054320335388,
0.11418995261192322,
0.06299588084220886,
0.01374481339007616,
-0.37665876746177673,
0.13265763223171234,
0.07535158842802048,
0.0813247486948967,
0.46285489201545715,
-0.006798450369387865,
0.1026158258318901,
0.20382508635520935,
-1.0845929384231567,
0.21248388290405273,
0.37523722648620605,
0.31351569294929504,
0.09645720571279526,
-0.390626460313797,
-0.23641082644462585,
0.4355561137199402,
-0.5980831980705261,
0.08086603879928589,
0.1749817132949829,
-0.18881841003894806,
0.012069149874150753,
-0.43254801630973816,
-0.1797819584608078,
0.45040252804756165,
0.007087427191436291,
-0.28415289521217346,
-0.2116987407207489,
-0.2351514995098114,
0.44257843494415283,
-0.159189373254776,
0.38839980959892273,
0.8830757141113281,
-0.5330999493598938,
0.24699293076992035,
0.2678779661655426,
0.17003703117370605,
0.2272021621465683,
-0.3582424223423004,
-0.08646394312381744,
-0.15433338284492493,
-0.664685845375061,
-0.36883431673049927,
0.023157557472586632,
0.2658861577510834,
-0.6380096673965454,
-0.5568632483482361,
0.18643471598625183,
-0.006339153740555048,
0.05022081732749939,
-0.37055543065071106,
0.07683328539133072,
0.07022952288389206,
-0.1431068778038025,
0.15820792317390442,
0.1438964307308197,
0.334967702627182,
-0.3811129927635193,
0.06453148275613785,
0.11038124561309814,
0.07850714772939682,
0.28915441036224365,
-0.029918735846877098,
-0.40966230630874634,
-0.32849371433258057,
0.3232311010360718,
0.1572110801935196,
0.09121603518724442,
0.21359829604625702,
0.26509371399879456,
-0.18165333569049835,
0.3850090503692627,
-0.019281450659036636,
-0.1363748461008072,
0.052954163402318954,
-0.774090051651001,
-0.5350093245506287,
-0.2504589855670929,
0.1151750460267067,
-0.14149209856987,
-0.006377594079822302,
-0.11749986559152603,
0.6385006904602051,
0.12857089936733246,
-0.17491118609905243,
-0.2512456774711609,
-0.1493092030286789,
0.3972497582435608,
0.1227157935500145,
0.017492931336164474,
-0.6031563878059387,
-0.005243990104645491,
0.4077642858028412,
-0.04805247113108635,
-0.23063600063323975,
-0.8596736192703247,
0.40837788581848145,
-0.5035941004753113,
0.1600375771522522,
0.5127018094062805,
0.2179069072008133,
0.10395266115665436,
0.13153348863124847,
-0.11874346435070038,
0.0357917882502079,
0.011529339477419853,
-0.02862219512462616,
-0.05686040595173836,
-0.13266031444072723,
0.47488781809806824,
0.4092376232147217,
-0.39263322949409485,
-0.011435797438025475,
-0.16417628526687622,
0.31448715925216675,
-0.03755562752485275,
0.49204036593437195,
-0.5777435302734375,
-0.3844591975212097,
0.3210916817188263,
-0.415382444858551,
-0.26723313331604004,
-0.34688881039619446,
0.01622704416513443,
0.47090229392051697,
0.37673574686050415,
0.28556519746780396,
-0.3364722728729248,
0.12978897988796234,
0.4580138921737671,
0.4173622131347656,
-0.631635308265686,
0.46409353613853455,
0.22944188117980957,
0.006812132429331541,
0.21092520654201508,
-0.7825592160224915,
0.4942105710506439,
0.2206498235464096,
-0.4225160777568817,
-0.20975568890571594,
0.4009503424167633,
-0.42336493730545044,
-0.08152404427528381,
0.15256623923778534,
-0.39006659388542175,
0.771401047706604,
0.08260677754878998,
-0.21586667001247406,
1.1053872108459473,
0.17140959203243256,
0.03681560605764389,
-1.0220389366149902,
0.09814567863941193,
0.011349382810294628,
0.5497373938560486,
0.43919968605041504,
0.06828824430704117,
0.5231307148933411,
0.5788477063179016,
0.05039011687040329,
0.4440653622150421,
0.027680980041623116,
-0.49466124176979065,
0.39720866084098816,
-0.4717472493648529,
0.22687053680419922,
0.04843982681632042,
0.07501284033060074,
0.6115918755531311,
-0.5531826615333557,
0.10393722355365753,
-0.17438416182994843,
0.6654417514801025,
-0.09043283760547638,
0.18619008362293243,
-0.47710704803466797,
0.9568889141082764,
0.5518780946731567,
-0.030998287722468376,
-0.07152580469846725,
-0.14169184863567352,
-0.1900036633014679,
0.06392928957939148,
0.6163954734802246,
-0.4680221974849701,
-0.6439768671989441,
0.6731428503990173,
0.06586624681949615,
0.8748741149902344,
-0.40546080470085144,
-0.1284162700176239,
-0.5382376909255981,
-0.12915802001953125,
0.5686123371124268,
0.007907244376838207,
0.30396902561187744,
0.03107774443924427,
-0.27803030610084534,
0.24812984466552734,
-0.47911718487739563,
-0.10539723932743073,
-0.40175861120224,
-0.49744734168052673,
0.4573988914489746,
-0.11660049855709076,
-0.05666222795844078,
0.10111289471387863,
-0.43116459250450134,
-0.06192687898874283,
-0.3670760691165924,
-0.3332051932811737,
0.17743904888629913,
-0.17512419819831848,
0.2531817853450775,
0.3314209580421448,
0.02739816904067993,
-0.30232101678848267,
-0.016472669318318367,
-0.7953633069992065,
-0.4508804380893707,
0.027839744463562965,
-0.18819239735603333,
-0.4992460310459137,
-0.3914467692375183,
0.5023772120475769,
0.017971474677324295,
0.2125004231929779,
-0.008236530236899853,
0.32174980640411377,
-0.004973114468157291,
0.7718884944915771,
-0.35685884952545166,
0.17143628001213074,
-0.16098594665527344,
-0.2864077389240265,
-0.540131151676178,
0.09696808457374573,
-0.13440871238708496,
0.6661617159843445,
-0.218474343419075,
0.1774986982345581,
0.27197831869125366,
0.29797452688217163,
-0.2529217004776001,
0.2298404425382614,
0.34459376335144043,
0.4788942337036133,
-0.19431671500205994,
-0.26448512077331543,
0.28859055042266846,
-0.11690535396337509,
-0.5107364654541016,
0.26031073927879333,
0.6695886254310608,
0.05486587435007095,
-0.5241453051567078,
0.021338609978556633,
0.1771143525838852,
-0.22377358376979828,
-0.6118874549865723,
0.03551087900996208,
-0.9457440376281738,
-0.651982843875885,
0.34106770157814026,
0.15268480777740479,
0.17583127319812775,
-0.913909375667572,
-0.6301122307777405,
0.0036025193985551596,
0.1774977147579193,
0.9060453772544861,
-0.1960989087820053,
0.0393412783741951,
-0.05871995538473129,
-0.22900648415088654,
-0.2382327765226364,
0.6690302491188049,
-0.12393337488174438,
0.6490856409072876,
-0.2527938187122345,
-0.755876362323761,
-0.28362607955932617,
0.1535821557044983,
-0.11850927025079727,
-0.23139598965644836,
0.16953694820404053,
0.3732959032058716
] |
ggplot2: Elegant Graphics for Data Analysis is a new addition to the UseR! series by Springer, probably the fastest expanding source of resources for computational statistics at the current moment. The books in this series are all linked with R, either presenting a new package developed by the own authors of the book or describing how to applying statistical techniques with the different packages available in R. ggplot2 is an implementation in R of The Grammar of Graphics (Wilkinson 2005) a systematic approach to the specification of statistical graphics that was introduced in a book previously reviewed in the Journal of Statistical Software by Cox (2007). This implementation has been developed by Hadley Wickham, who is also the author of the book reviewed here. | [
-0.012300563976168633,
0.017292598262429237,
-0.003982480149716139,
0.006065814755856991,
-0.0017981696873903275,
-0.019137807190418243,
0.005294164642691612,
-0.014464674517512321,
-0.006270218640565872,
-0.006313590332865715,
-0.01083461381494999,
0.006135486997663975,
0.002626401372253895,
-0.0007045179372653365,
-0.017613383010029793,
0.010863053612411022,
-0.008320690132677555,
0.010031260550022125,
0.004702556878328323,
0.010999048128724098,
-0.0052467272616922855,
0.017731187865138054,
0.0063814520835876465,
0.016525130718946457,
-0.003204865613952279,
-0.009622843004763126,
-0.012802177108824253,
-0.007431856356561184,
-0.004095111973583698,
0.01219584047794342,
0.008045748807489872,
0.01176452450454235,
0.014237664639949799,
-0.016287902370095253,
0.00016750406939536333,
0.008987968787550926,
-0.007490167394280434,
0.014470204710960388,
-0.012878136709332466,
-0.002407217165455222,
-0.0019028004026040435,
-0.0035748640075325966,
0.0010247124591842294,
-0.016918925568461418,
-0.008516136556863785,
0.01510648149996996,
-0.0022243368439376354,
-0.0027500728610903025,
-0.012194540351629257,
0.0076986039057374,
-0.0020931102335453033,
0.03444046154618263,
0.0017787201795727015,
0.010622881352901459,
-0.003340732306241989,
0.0077308001928031445,
0.011460630223155022,
0.014362655580043793,
-0.014984220266342163,
0.016905665397644043,
-0.0013996278867125511,
0.022088663652539253,
-0.011950630694627762,
-0.005720228888094425,
0.010127334855496883,
-0.068145252764225,
-0.01568654552102089,
0.00939948484301567,
0.012092776596546173,
0.005556108430027962,
-0.004300153814256191,
0.009818699210882187,
-0.006442762911319733,
0.010128594934940338,
-0.010348960757255554,
-0.0031101396307349205,
-0.014188533648848534,
0.006033820565789938,
0.0023167943581938744,
0.003040588926523924,
0.0053236037492752075,
-0.01338352169841528,
-0.007512015290558338,
0.024716617539525032,
-0.002196346642449498,
0.002575370715931058,
-0.007051619701087475,
-0.018127886578440666,
-0.003007314633578062,
-0.01248961128294468,
0.008021153509616852,
-0.023035787045955658,
-0.0007616854272782803,
0.007635363843291998,
-0.0175020731985569,
0.003288207808509469,
0.02577795460820198,
-0.022879375144839287,
-0.001843371894210577,
-0.006725669838488102,
-0.003268127329647541,
0.04052326828241348,
0.011908914893865585,
-0.007599196396768093,
-0.003914622589945793,
0.006430195644497871,
0.00702148862183094,
0.007006591651588678,
-0.01055360771715641,
0.0028124740347266197,
0.009616093710064888,
0.004223561845719814,
0.008987734094262123,
0.0014050053432583809,
-0.021078389137983322,
0.012346173636615276,
-0.0026334640569984913,
0.00042600836604833603,
0.004003660753369331,
0.004698668606579304,
0.007716779131442308,
-0.00042079435661435127,
0.00007768301293253899,
-0.013659575022757053,
0.006867010612040758,
0.007290097419172525,
0.012789085507392883,
0.003322763368487358,
0.003657315392047167,
-0.0029997609090059996,
-0.009709831327199936,
-0.010456113144755363,
-0.007747692987322807,
-0.004770096857100725,
-0.011464893817901611,
-0.002606986090540886,
0.0014536355156451464,
0.014590637758374214,
0.009012932889163494,
-0.00008649495430290699,
-0.0066575221717357635,
0.006474420893937349,
0.003478948026895523,
0.012383104301989079,
0.009701046161353588,
-0.0013939315686002374,
0.012205821461975574,
0.00311489962041378,
-0.004445327911525965,
-0.01843661069869995,
-0.0016312957741320133,
-0.011832522228360176,
-0.005262455902993679,
0.003993341699242592,
0.010074211284518242,
-0.012837599962949753,
-0.014193002134561539,
-0.010056126862764359,
-0.010342782363295555,
0.008707312867045403,
-0.0064493766985833645,
-0.002688643056899309,
0.008373302407562733,
0.006776837166398764,
-0.014110582880675793,
-0.0102305356413126,
-0.027401579543948174,
-0.001596471993252635,
-0.0033408296294510365,
-0.0008056981023401022,
-0.007867041043937206,
0.021812211722135544,
0.01754763349890709,
0.0019897250458598137,
0.002365474821999669,
-0.009585805237293243,
0.004675941541790962,
0.002654873766005039,
-0.00758415088057518,
0.0674259290099144,
0.002347019501030445,
-0.010507412254810333,
-0.017687473446130753,
0.024334676563739777,
-0.014309543184936047,
-0.00512345926836133,
0.017825307324528694,
-0.00044183252612128854,
0.004455655813217163,
0.003986208233982325,
-0.013559768907725811,
0.02606709487736225,
-0.002719747368246317,
0.002915150485932827,
-0.0028140456415712833,
0.0013021244667470455,
0.007474642246961594,
-0.00849948450922966,
0.019423430785536766,
0.019041314721107483,
-0.0008854835759848356,
0.01004275493323803,
0.018425440415740013,
0.007373039610683918,
-0.00017209560610353947,
0.006952357478439808,
0.0004217289388179779,
-0.023142628371715546,
-0.005463097244501114,
0.0065644229762256145,
-0.001807760912925005,
-0.011102400720119476,
-0.004913378972560167,
0.0016382616013288498,
-0.032871320843696594,
0.01340534444898367,
-0.010395128279924393,
-0.01622176170349121,
0.012066500261425972,
-0.010098229162395,
-0.0015560751780867577,
-0.003043290227651596,
-0.021883537992835045,
-0.042592160403728485,
0.015522199682891369,
-0.021322304382920265,
-0.005687280558049679,
0.005837623029947281,
-0.005105047952383757,
-0.0028486456722021103,
0.006528157275170088,
0.02261866256594658,
-0.007134434767067432,
-0.0013553224271163344,
0.018194571137428284,
-0.009044632315635681,
0.003410033416002989,
-0.009596221148967743,
0.006600173190236092,
-0.001103533897548914,
-0.018456872552633286,
-0.016432588919997215,
0.007306784391403198,
-0.006629352457821369,
0.004564054310321808,
-0.010195387527346611,
0.014947187155485153,
-0.010806756094098091,
-0.007974178530275822,
-0.014443754218518734,
0.0007865114603191614,
0.004798476584255695,
-0.009735447354614735,
-0.009314720518887043,
-0.015169046819210052,
-0.0026811654679477215,
-0.012046920135617256,
-0.00587537232786417,
0.018611807376146317,
-0.0052602216601371765,
-0.0004741101001854986,
0.005434870719909668,
0.019235989078879356,
-0.0038816584274172783,
-0.011939242482185364,
0.003555822651833296,
0.011961665004491806,
0.01661042496562004,
0.012482892721891403,
-0.005753565113991499,
0.001471737283281982,
-0.007570389658212662,
-0.004451594781130552,
-0.08224605023860931,
-0.008818917907774448,
0.014772485941648483,
0.021177327260375023,
0.007296569645404816,
-0.020145181566476822,
-0.006127858068794012,
-0.006185553036630154,
-0.011349684558808804,
0.006235500797629356,
0.0036022921558469534,
-0.013681096956133842,
-0.0030521827284246683,
-0.004042892716825008,
0.02319987863302231,
-0.005043102893978357,
0.014134245924651623,
-0.0014221854507923126,
-0.007216278463602066,
0.014967691153287888,
0.009794835932552814,
0.002951687900349498,
0.011884313076734543,
-0.0069107795134186745,
0.01666165515780449,
0.001554054906591773,
0.007475328631699085,
0.005971923004835844,
-0.0032082446850836277,
-0.002511662431061268,
-0.012730803340673447,
-0.026029197499155998,
0.010130840353667736,
-0.003504582680761814,
0.024039501324295998,
-0.004582790657877922,
-0.002796690445393324,
-0.005016810726374388,
-0.006401268765330315,
0.008537715300917625,
-0.015555175021290779,
0.002795959822833538,
-0.016339479014277458,
-0.0020936299115419388,
-0.00311779766343534,
0.002483612159267068,
-0.00037328596226871014,
0.004069805610924959,
0.009933561086654663,
-0.003688609227538109,
0.029532838612794876,
-0.001003082375973463,
0.018391801044344902,
0.005510461516678333,
-0.003986176569014788,
0.01285284198820591,
-0.011994810774922371,
-0.0038145550061017275,
-0.009402364492416382,
0.005031548906117678,
0.006221338640898466,
0.0061026099137961864,
0.014332669787108898,
0.0018713432364165783,
0.003688687225803733,
-0.017344973981380463,
0.009570885449647903,
0.008731245063245296,
-0.0045222570188343525,
-0.011155003681778908,
0.007741614244878292,
-0.0018880259012803435,
-0.004191613756120205,
-0.002302450593560934,
-0.0016117142513394356,
-0.013296051882207394,
-0.009037666022777557,
-0.008419198915362358,
0.0013716131215915084,
-0.0029164976440370083,
0.006977379322052002,
0.012029474601149559,
0.006984037347137928,
-0.005878753028810024,
0.000888829817995429,
-0.009827099740505219,
0.00515695009380579,
-0.02477554976940155,
0.002167767845094204,
-0.010110080242156982,
0.015791980549693108,
0.01294795610010624,
-0.004699284210801125,
0.006280739791691303,
0.007162608206272125,
-0.035683657974004745,
0.01913169026374817,
-0.0037559280171990395,
0.021307479590177536,
0.004582581110298634,
-0.012352409772574902,
-0.011476913467049599,
0.00911331083625555,
-0.008715992793440819,
-0.002336462028324604,
0.0043295444920659065,
-0.010720916092395782,
-0.001302819000557065,
-0.0022622807882726192,
-0.0022373381070792675,
-0.0031123284716159105,
-0.00555034726858139,
-0.009568927809596062,
0.04166247695684433,
0.0007340118754655123,
-0.013108676299452782,
-0.014464710839092731,
0.007136916276067495,
0.0743137076497078,
-0.018520589917898178,
0.019120216369628906,
-0.01981734111905098,
0.008398016914725304,
-0.007962099276483059,
-0.012325871735811234,
0.02213052660226822,
-0.011168083176016808,
-0.004807546269148588,
0.006659527309238911,
0.011320539750158787,
-0.0060152532532811165,
-0.023451993241906166,
-0.015436956658959389,
0.010052026249468327,
0.006626217160373926,
-0.012965107336640358,
0.01909063570201397,
0.002863154513761401,
-0.014159899204969406,
0.0076044355519115925,
-0.016867179423570633,
-0.020984476432204247,
-0.028133001178503036,
0.0039823465049266815,
0.01107963640242815,
-0.013441650196909904,
-0.007210836745798588,
0.002424831734970212,
0.009281307458877563,
0.007878163829445839,
-0.007376178167760372,
0.009083532728254795,
0.007581342943012714,
0.026713255792856216,
-0.010021038353443146,
-0.020768310874700546,
0.005400483496487141,
0.006910077761858702,
0.017535008490085602,
-0.012393979355692863,
0.0017112959176301956,
0.007443814538419247,
-0.00436924584209919,
-0.0001233064103871584,
0.017352178692817688,
-0.008757099509239197,
0.0019307788461446762,
0.032615840435028076,
0.007983054965734482,
0.006251269951462746,
0.007730436511337757,
-0.02258644625544548,
0.008064967580139637,
0.0020256591960787773,
0.00022794026881456375,
-0.004557678010314703,
-0.0039027882739901543,
0.002540440997108817,
-0.006517183035612106,
-0.002538044936954975,
-0.006475575268268585,
-0.00023737712763249874,
0.0001768535003066063,
-0.0053426409140229225,
-0.01844860054552555,
-0.013081362470984459,
-0.0027900217100977898,
0.008203480392694473,
0.021171418949961662,
-0.011591842398047447,
-0.01439903024584055,
-0.0071978275664150715,
-0.0025369087234139442,
-0.014148103073239326,
-0.013473092578351498,
0.005482364911586046,
0.023982835933566093,
-0.003683274146169424,
0.003059149719774723,
-0.009236824698746204,
-0.02700071595609188,
-0.007302991580218077,
0.018085572868585587,
-0.00659124506637454,
-0.008754313923418522,
-0.0756831243634224,
-0.020386915653944016,
-0.005561067722737789,
0.001443508081138134,
-0.010293805971741676,
0.005200855899602175,
-0.00038262654561549425,
-0.014514745213091373,
-0.011247970163822174,
-0.00047203348367474973,
0.002712658606469631,
-0.01770034432411194,
-0.0067894537933170795,
-0.001660988200455904,
0.006070946343243122,
0.004407563246786594,
0.004067139234393835,
-0.0011404277756810188,
0.02248338609933853,
0.01094726100564003,
0.0054894257336854935,
0.0025005044881254435,
0.0015434816014021635,
-0.0065129464492201805,
-0.018872447311878204,
-0.0832633227109909,
-0.03225574642419815,
-0.0017200000584125519,
0.0030455964151769876,
0.004223703406751156,
-0.02242889069020748,
0.0026888130232691765,
-0.022203948348760605,
-0.013639293611049652,
-0.007690140046179295,
0.01099510956555605,
0.00703144958242774,
0.006878883112221956,
0.013869397342205048,
0.018356284126639366,
-0.0026634149253368378,
0.01363723911345005,
0.002114964183419943,
0.012919140048325062,
-0.004636371973901987,
-0.018963797017931938,
-0.01721147820353508,
-0.004484259523451328,
0.008851861581206322,
-0.006074880249798298,
0.004985671956092119,
-0.018819434568285942,
0.012760048732161522,
0.016190603375434875,
-0.009325976483523846,
-0.004806310869753361,
0.0006795129156671464,
0.008073991164565086,
-0.034330859780311584,
-0.027430923655629158,
-0.0026364773511886597,
0.01590842381119728,
-0.003069608472287655,
-0.00020397454500198364,
-0.015246840193867683,
-0.001242185477167368,
-0.00041442865040153265,
-0.008041816763579845,
-0.0009753834456205368,
0.0066065238788723946,
0.0012598815374076366,
0.003839486977085471,
-0.0024922501761466265,
0.0024509383365511894,
-0.006014861632138491,
0.0020324874203652143,
-0.01568947732448578,
-0.004131061024963856,
0.007115938235074282,
0.0008267713710665703,
-0.007575379218906164,
0.004438742063939571,
0.017509689554572105,
0.0038413815200328827,
0.00788043811917305,
0.002075090305879712,
0.03654956445097923,
-0.008278574794530869,
0.07273374497890472,
-0.009165204130113125,
0.016873998567461967,
-0.01615234464406967,
0.005397237371653318,
0.00018020783318206668,
-0.010309168137609959,
-0.019913200289011,
0.008575625717639923,
-0.02010742947459221,
0.014403849840164185,
-0.009610144421458244,
0.0049573262222111225,
-0.002628978807479143,
-0.001546727493405342,
-0.018244203180074692,
-0.0030700289644300938,
0.010594842955470085,
0.011092393659055233,
-0.0015591706614941359,
0.022077370434999466,
0.024436375126242638,
0.006381148938089609,
-0.006954994983971119,
-0.013278733938932419,
0.0007598749361932278,
-0.0015021716244518757,
0.010411755181849003,
0.008672749623656273,
-0.023526618257164955,
0.00031119491904973984,
-0.04019619897007942,
0.0003658552886918187,
0.009782453998923302,
0.013461777940392494,
-0.007550753653049469,
-0.00031039491295814514,
0.005595675203949213,
-0.006755902897566557,
-0.018657848238945007,
0.017679138109087944,
-0.008801311254501343,
-0.003360665636137128,
-0.005512515548616648,
0.013081560842692852,
0.01874343678355217,
0.010843245312571526,
0.007314309943467379,
0.014746896922588348,
-0.0028496412560343742,
-0.00747074605897069,
0.0003566127270460129,
0.0005934496875852346,
0.0060950834304094315,
0.004887710325419903,
-0.0037420373409986496,
0.01421147957444191,
0.004135363735258579,
-0.00012721167877316475,
0.008660240098834038,
0.008174685761332512,
-0.0049203550443053246,
0.010655419901013374,
0.0017525795847177505,
0.006807687692344189,
0.013647658750414848,
-0.01737922430038452,
-0.018614094704389572,
0.014478374272584915,
0.007918685674667358,
-0.0008359737694263458,
0.010236391797661781,
0.0006385257584042847,
0.002774803666397929,
0.005262681748718023,
0.00872341450303793,
0.00011614803224802017,
-0.012958100065588951,
0.015676802024245262,
-0.006067782640457153,
-0.001506333821453154,
0.00445209676399827,
0.016084665432572365,
-0.022930586710572243,
0.005556939635425806,
-0.002489534905180335,
-0.007586626335978508,
0.016604658216238022,
0.0046896422281861305,
0.01057061180472374,
0.00585311371833086,
0.001680075889453292,
0.0028275554068386555,
-0.008018003776669502,
0.006123263854533434,
0.031413234770298004,
0.02046089433133602,
0.0058537633158266544,
-0.016593415290117264,
-0.017880208790302277,
-0.004641645587980747,
0.02331661805510521,
-0.0024883723817765713,
-0.0007059015333652496,
-0.007405195850878954,
-0.004710788372904062,
-0.005533675663173199,
0.0037193475291132927,
-0.012045055627822876,
-0.00619474658742547,
0.030125265941023827,
0.01229184865951538,
-0.011676251888275146,
0.02046860009431839,
-0.00907437689602375,
-0.012878863140940666,
-0.010763661004602909,
-0.008500649593770504,
0.003557744435966015,
-0.00804175902158022,
0.004333429038524628,
0.008125579915940762,
-0.0058039212599396706,
0.013994927518069744,
0.02513677068054676,
-0.0017514361534267664,
-0.005743247456848621,
-0.004346773028373718,
0.011188260279595852,
-0.01771172136068344,
0.008027322590351105,
0.017428994178771973,
-0.010557485744357109,
0.009561754763126373,
0.003458427730947733,
-0.009334174916148186,
-0.0027351905591785908,
0.0041707237251102924,
0.0071901194751262665,
0.012683016248047352,
0.01954076439142227,
-0.022121157497167587,
0.006413673982024193,
0.010460987687110901,
0.004916666075587273,
-0.005989345721900463,
0.008106464520096779,
0.0514744371175766,
-0.004140564706176519,
0.01658697798848152,
0.01799968257546425,
0.010138250887393951,
-0.028439944609999657,
-0.005322456359863281,
-0.003964611794799566,
0.00626360671594739,
-0.0038691789377480745,
-0.0005401482339948416,
0.007809082046151161,
0.006691738963127136,
-0.0019450918771326542,
-0.010296180844306946,
-0.010177183896303177,
0.0040681129321455956,
-0.00701840128749609,
0.006746146362274885,
-0.003970731981098652,
0.0043077850714325905,
-0.0011433102190494537,
-0.016295908018946648,
0.010226301848888397,
-0.000429574865847826,
-0.0035444970708340406,
-0.004875601269304752,
-0.0018439553678035736,
-0.0059381225146353245,
-0.014738637022674084,
0.012188343331217766,
-0.0013334918767213821,
0.011837758123874664,
0.012167880311608315,
-0.010745014995336533,
0.007984964177012444,
-0.006830934435129166,
-0.0063479142263531685,
0.014677359722554684,
-0.0030296300537884235,
-0.000209086574614048,
-0.004138650372624397,
0.0046836091205477715,
0.010170788504183292,
0.005465010646730661,
-0.023219991475343704,
0.02231895923614502,
-0.0007363986223936081,
-0.0161837600171566,
-0.0015834691002964973,
0.0030178255401551723,
0.02178121544420719,
0.010682884603738785,
0.00588300172239542,
-0.00000215345062315464
] | [
-0.4953548014163971,
0.04513882100582123,
0.6802999377250671,
-0.2762165069580078,
-0.6396903395652771,
-0.19579695165157318,
0.1926003098487854,
-0.3851463794708252,
-0.2995580732822418,
-0.6747758984565735,
-0.4872503876686096,
0.4777272939682007,
-0.7967652082443237,
-0.8439025282859802,
0.1156073659658432,
0.5828232169151306,
0.6651819944381714,
0.18493013083934784,
-0.9116186499595642,
-0.7509505152702332,
-0.05250440910458565,
-0.26082417368888855,
0.003485711058601737,
-0.08224468678236008,
-0.18206505477428436,
0.364666223526001,
0.8936730027198792,
0.5768580436706543,
-0.5560086369514465,
-0.04456012696027756,
0.04750175029039383,
0.5541296005249023,
-0.20620885491371155,
-0.25457707047462463,
0.04817367345094681,
0.1926889717578888,
0.03776780143380165,
-0.24464289844036102,
0.2422458678483963,
0.14295463263988495,
0.19565631449222565,
0.17455095052719116,
-0.33123278617858887,
0.36077627539634705,
0.14135617017745972,
-0.08956224471330643,
-1.719773292541504,
0.07946626096963882,
-0.6782736778259277,
0.10417907685041428,
-0.3167756199836731,
0.37299901247024536,
0.1349322497844696,
0.9131720662117004,
0.014807002618908882,
0.6846832036972046,
-0.7087442278862,
-0.14309808611869812,
-0.18083426356315613,
-0.4232557713985443,
-0.059049975126981735,
-0.18693207204341888,
-0.1918850839138031,
0.2834852635860443,
-0.186287060379982,
0.4449268579483032,
-0.21908558905124664,
0.12847872078418732,
-0.5104617476463318,
-0.4765438735485077,
0.6850579380989075,
-0.6983992457389832,
-0.3214430809020996,
0.19428782165050507,
0.11104680597782135,
0.08161433041095734,
-0.31034430861473083,
-0.21422140300273895,
0.26908600330352783,
0.07333032041788101,
0.13042789697647095,
0.1456378847360611,
0.9766245484352112,
-0.24420973658561707,
0.6029613018035889,
0.25060027837753296,
-0.11916569620370865,
0.380368709564209,
-0.37227511405944824,
0.0959838405251503,
-0.2197667360305786,
-1.1652015447616577,
0.15049123764038086,
0.629967212677002,
1.0695372819900513,
0.304554283618927,
-0.08038121461868286,
0.06068817153573036,
0.6288298964500427,
0.28349950909614563,
0.050284191966056824,
-0.1505105346441269,
0.03142337501049042,
-0.14867767691612244,
-1.1235506534576416,
-0.6810460090637207,
-0.66096431016922,
-0.9829251170158386,
-0.28984513878822327,
0.5168255567550659,
-0.5918196439743042,
0.2652125060558319,
-0.1332547813653946,
-0.654390275478363,
-0.06366303563117981,
0.571621298789978,
-0.05832416191697121,
0.058390337973833084,
-0.5602172613143921,
0.7586652040481567,
0.5747770071029663,
0.5448647737503052,
0.5401660799980164,
0.8065788149833679,
0.3135758936405182,
0.17516209185123444,
0.49870729446411133,
1.1507660150527954,
-0.2905429005622864,
0.30231305956840515,
0.321422278881073,
1.0852185487747192,
0.31845301389694214,
-0.308136522769928,
0.009986067190766335,
-0.709769606590271,
0.2690292000770569,
-0.167249858379364,
-0.5781096816062927,
0.33558496832847595,
-0.26726797223091125,
0.10946127027273178,
-0.0934266522526741,
-0.4863581657409668,
0.03632586821913719,
-0.29806867241859436,
-0.03758286312222481,
-0.5095495581626892,
-0.15297581255435944,
-0.42776042222976685,
0.1076376661658287,
-0.1189095675945282,
-0.7048285007476807,
-0.11029233783483505,
-0.21818985044956207,
1.4390560388565063,
0.1622074395418167,
-0.1104414314031601,
-0.06853301078081131,
0.19790412485599518,
0.5012118816375732,
0.06636907160282135,
-0.70683354139328,
-0.16889837384223938,
0.18736574053764343,
-0.30099382996559143,
0.10586918145418167,
0.5086008310317993,
0.49762582778930664,
-0.13306677341461182,
-0.4871015250682831,
-0.45330050587654114,
-0.053944170475006104,
-0.01487741619348526,
0.12343659996986389,
0.1285082995891571,
1.0222175121307373,
0.10409902781248093,
0.3842141926288605,
-0.04612597078084946,
-0.9471713900566101,
-0.18451151251792908,
0.3022332787513733,
-0.3987214267253876,
0.6810316443443298,
0.029474670067429543,
0.7112768888473511,
-0.10643481463193893,
0.22770537436008453,
0.342655211687088,
-0.34748589992523193,
-0.0776478499174118,
0.17870117723941803,
-0.8018465042114258,
1.6809381246566772,
0.09341460466384888,
-0.5966891646385193,
0.7520601749420166,
-0.4029776155948639,
0.507526159286499,
-0.23789173364639282,
0.3192860186100006,
0.8325075507164001,
-0.009154679253697395,
-0.0967756062746048,
-0.3048288822174072,
-0.12476319819688797,
0.1260247677564621,
-0.9599825739860535,
0.8150550723075867,
0.3902038633823395,
-0.0074149249121546745,
-0.021257812157273293,
-0.010136513970792294,
0.3314630389213562,
0.2385038584470749,
0.09180159866809845,
-0.10891643166542053,
-0.24441838264465332,
0.24429039657115936,
1.1047841310501099,
-0.1442931592464447,
0.12036193907260895,
0.30672329664230347,
0.04916315898299217,
0.8389629125595093,
0.9810463190078735,
0.5610413551330566,
1.1159722805023193,
-0.4108099937438965,
-0.4614364802837372,
0.559441864490509,
0.9195836186408997,
-0.5777044296264648,
-0.2811454236507416,
0.017140289768576622,
0.2580889165401459,
-0.404561847448349,
0.24793855845928192,
-0.09289126098155975,
0.327919602394104,
0.2336108535528183,
-0.13720175623893738,
-0.034445278346538544,
0.258916974067688,
-0.33123141527175903,
-0.033860091120004654,
0.46660110354423523,
-0.14213328063488007,
-0.6106130480766296,
0.8141090869903564,
0.5328415632247925,
-0.04902248829603195,
-0.5857996940612793,
-0.016259407624602318,
0.40992334485054016,
-0.14757536351680756,
-0.4773675203323364,
0.17908340692520142,
0.6652087569236755,
-0.32180532813072205,
-0.39585331082344055,
0.10947524756193161,
0.3137904107570648,
-0.19690914452075958,
-0.3574122190475464,
-0.3453565835952759,
-0.2329590767621994,
0.6193298101425171,
0.8131858706474304,
-0.13915301859378815,
-0.1507410705089569,
-0.7454909682273865,
0.18795421719551086,
-0.44137853384017944,
-0.7556988596916199,
0.012046458199620247,
-0.07082437723875046,
-0.9443322420120239,
-0.5336570143699646,
-0.05902007967233658,
0.5458914637565613,
0.9349698424339294,
-0.11753574013710022,
-0.8162177205085754,
-0.07588997483253479,
0.4165653884410858,
-0.6952012777328491,
-0.5590863227844238,
-0.08320166915655136,
0.060806892812252045,
0.2698371708393097,
-0.15297536551952362,
-0.5428258180618286,
0.5109775066375732,
0.7120322585105896,
-0.22070378065109253,
-0.008265592157840729,
0.2869252860546112,
0.041883330792188644,
0.09237619489431381,
0.1642799824476242,
0.02197798155248165,
0.021677035838365555,
0.3627994656562805,
-0.5025302767753601,
-0.46684530377388,
0.36933866143226624,
-5.292026996612549,
-0.2598237097263336,
-0.5976579785346985,
0.18412072956562042,
-0.9674524068832397,
-0.29442986845970154,
0.6293447613716125,
-0.2953875660896301,
0.3555520474910736,
-0.4011823534965515,
-0.19414184987545013,
0.18597102165222168,
-0.17100711166858673,
0.7254666686058044,
-0.08160948753356934,
0.5356014370918274,
0.5639120936393738,
0.17335113883018494,
0.136455237865448,
0.3585108816623688,
0.7512693405151367,
-0.39636051654815674,
0.12373235821723938,
-0.10362940281629562,
0.8044382929801941,
0.2388118952512741,
-0.9824694991111755,
0.29028835892677307,
-0.012901120819151402,
-0.16942600905895233,
0.27602219581604004,
-0.008698539808392525,
-0.3626664876937866,
-0.23188328742980957,
0.11328327655792236,
0.2550463080406189,
0.8398406505584717,
-0.028478866443037987,
0.6071080565452576,
-0.6959099173545837,
0.6858394145965576,
0.6924175024032593,
0.06901084631681442,
-0.1432175189256668,
0.2962675094604492,
-0.6023187041282654,
-0.6823537349700928,
0.5077336430549622,
-0.20383261144161224,
1.1649279594421387,
-0.24408914148807526,
-0.22721226513385773,
-0.08516808599233627,
0.5297031402587891,
-0.21769843995571136,
-0.6017889380455017,
-0.10247164964675903,
0.3400583863258362,
-0.13195790350437164,
0.4311545193195343,
0.21413175761699677,
-0.5326521992683411,
-0.11155752092599869,
-0.6986083984375,
-0.5827256441116333,
0.3494267761707306,
-0.9159431457519531,
-0.7255417108535767,
0.1434447020292282,
0.08930453658103943,
-0.709738552570343,
0.5380706191062927,
0.09277249127626419,
-0.6117275953292847,
0.796251118183136,
-0.1939067542552948,
-0.30205899477005005,
-0.20940902829170227,
0.2885434031486511,
0.1740843504667282,
0.09734848886728287,
-0.8518528938293457,
-0.1995924413204193,
0.1293153613805771,
0.029170546680688858,
-0.6813436150550842,
-0.32596784830093384,
0.05745125561952591,
-0.3013092279434204,
0.137226402759552,
0.6454649567604065,
-0.6062970757484436,
0.18030115962028503,
0.7288422584533691,
0.1463005691766739,
0.32671812176704407,
0.8895772695541382,
-0.4805111885070801,
0.3456839919090271,
-0.25218865275382996,
0.4196746349334717,
-0.012605818919837475,
-0.011035059578716755,
-0.5184146165847778,
-0.04898262768983841,
0.041893891990184784,
-0.6993987560272217,
0.1591341197490692,
0.7131058573722839,
-0.3271132707595825,
-0.16334232687950134,
-0.34651055932044983,
-0.5856877565383911,
-0.07944682985544205,
0.7142613530158997,
0.2040981650352478,
-0.319980263710022,
-0.17466618120670319,
0.12612281739711761,
-0.41190001368522644,
0.17824776470661163,
-0.2324153482913971,
-0.02960561029613018,
-0.08099739253520966,
-0.014291531406342983,
0.15010710060596466,
0.48640531301498413,
0.21794858574867249,
-0.46958810091018677,
0.15004253387451172,
-0.3513626754283905,
-0.004541717004030943,
-0.07981055229902267,
0.1551029235124588,
0.6136177778244019,
-0.7273884415626526,
-0.4916149079799652,
0.22520610690116882,
0.3200395405292511,
-0.8228461146354675,
0.5495145916938782,
0.042391493916511536,
-0.30981308221817017,
-0.6327257752418518,
-0.029581649228930473,
0.3776578903198242,
0.0027142823673784733,
-0.035861462354660034,
-0.33409884572029114,
0.13005270063877106,
-0.20220214128494263,
-0.5840904116630554,
0.4051317274570465,
-0.24446448683738708,
-0.1995682567358017,
-0.044994063675403595,
0.08664310723543167,
0.7807992100715637,
0.3318919837474823,
-0.5285307765007019,
0.5993297100067139,
0.2956541180610657,
-0.9606618285179138,
0.2917931079864502,
0.4838317930698395,
0.05563298612833023,
0.2290736585855484,
-0.1755869835615158,
-0.5171271562576294,
0.08128135651350021,
0.09183809906244278,
-0.24585872888565063,
0.12263847142457962,
-0.26565152406692505,
0.2955555319786072,
-0.11402696371078491,
-0.13520734012126923,
0.10132358968257904,
0.14344869554042816,
0.40406593680381775,
0.12123611569404602,
-0.875893235206604,
0.08490346372127533,
0.5946747064590454,
0.6874277591705322,
-0.33287331461906433,
0.09438415616750717,
-0.12498462945222855,
-0.2437879890203476,
-0.6093924045562744,
0.5058243274688721,
0.40520039200782776,
0.6446815133094788,
0.08126562088727951,
-0.4882144033908844,
-0.8805729150772095,
0.2693724036216736,
-0.0950406864285469,
-0.09980173408985138,
-0.8046820759773254,
-0.15998025238513947,
0.5671331286430359,
0.15811984241008759,
0.43310388922691345,
0.23815354704856873,
-0.5041899681091309,
-0.08206754177808762,
-0.2424027919769287,
0.05305146425962448,
0.2896595299243927,
0.0026752224657684565,
-0.48677656054496765,
0.26339614391326904,
-0.21537549793720245,
-0.5249705910682678,
0.4937480092048645,
0.21826471388339996,
-0.29758137464523315,
-0.9941298365592957,
0.4859292805194855,
-0.31070104241371155,
-0.6071869730949402,
-0.5773376822471619,
-0.03304034471511841,
-0.42182424664497375,
0.05350474268198013,
0.40371689200401306,
-0.5006378889083862,
0.07561595737934113,
-0.5553706884384155,
0.20028093457221985,
0.12623542547225952,
-0.0867563933134079,
0.050081368535757065,
-0.29910698533058167,
-0.09254084527492523,
-0.5116602182388306,
0.9260584115982056,
0.1435825377702713,
-0.2766619026660919,
0.309088796377182,
0.5470184087753296,
0.007459726650267839,
-0.5892373919487,
0.2243499606847763,
-0.24046041071414948,
-0.0859205573797226,
-0.5310580134391785,
-0.9932275414466858,
0.05795380473136902,
0.05574478954076767,
-0.026171596720814705,
0.2917805314064026,
-0.445086270570755,
0.8529844284057617,
-0.06549538671970367,
-0.6720240116119385,
-0.4886774718761444,
-0.042933717370033264,
0.24158117175102234,
0.04079554229974747,
0.21540121734142303,
-0.6828650236129761,
-0.6122559309005737,
0.3295856714248657,
0.2440177947282791,
0.09777478873729706,
-0.8181625604629517,
0.11699946969747543,
0.06879395246505737,
-0.4387683570384979,
-0.002140871249139309,
-0.23434531688690186,
-0.03551877662539482,
0.09283649176359177,
-0.3905159831047058,
-0.6126413941383362,
0.02390432544052601,
0.11465807259082794,
0.15066790580749512,
-0.2756156921386719,
-0.25700584053993225,
0.46900612115859985,
-0.2776220738887787,
0.23550470173358917,
0.05103936418890953,
0.27528780698776245,
0.31300345063209534,
0.34399139881134033,
0.49483123421669006,
0.05133196711540222,
-0.06505908071994781,
-0.7173032760620117,
-0.3335336148738861,
-0.06456290930509567,
0.20786254107952118,
0.40011703968048096,
-0.23325398564338684,
-0.2498624324798584,
-0.3048027455806732,
0.4125346541404724,
0.6136406064033508,
0.41572028398513794,
-0.3225480616092682,
0.20898927748203278,
0.37972667813301086,
0.13277983665466309,
-0.033563703298568726,
-0.3057172894477844,
0.5155861973762512,
0.059084996581077576,
-0.39699751138687134,
0.21672432124614716,
0.5910084247589111,
-0.6136417388916016,
0.622019350528717,
0.0024463138543069363,
0.03678920492529869,
0.8631937503814697,
-0.138514444231987,
0.15468916296958923,
0.6224105954170227,
0.48129183053970337,
0.036432843655347824,
-1.1268385648727417,
0.46022680401802063,
-0.2846384346485138,
0.3353411555290222,
0.44474610686302185,
-0.35206863284111023,
0.7213950157165527,
0.7111802101135254,
-0.03720852732658386,
0.3803439438343048,
-0.2680329978466034,
-0.1243266835808754,
0.17578554153442383,
0.03449002280831337,
0.26223519444465637,
0.1826544553041458,
0.40281009674072266,
0.6066104173660278,
-0.2992740869522095,
0.1315397322177887,
-0.5180492401123047,
0.28461530804634094,
-0.2760324478149414,
-0.150943323969841,
-0.22008748352527618,
0.4349621534347534,
0.4429311454296112,
0.31912317872047424,
-0.5500973463058472,
0.20006951689720154,
-0.625468373298645,
-0.35800865292549133,
0.1496572196483612,
-0.46145838499069214,
0.20315320789813995,
0.4430936276912689,
0.6044833064079285,
0.5775843858718872,
-0.3729291260242462,
0.1752987653017044,
-0.9501266479492188,
0.05911535024642944,
0.5918025374412537,
0.07295528054237366,
0.4138237237930298,
-0.1461086869239807,
-0.7810002565383911,
0.22742486000061035,
-0.1904769241809845,
0.11019711196422577,
-0.35187017917633057,
-0.5022956728935242,
0.640807569026947,
-0.18556708097457886,
-0.2820016145706177,
0.683120846748352,
-0.4974879026412964,
0.013501554727554321,
-0.6006925106048584,
-0.27548831701278687,
0.1052059680223465,
-0.8157303333282471,
0.28483709692955017,
0.001200548023916781,
-0.11038759350776672,
-0.2542076110839844,
0.008926188573241234,
-0.5805155038833618,
-0.6578461527824402,
-0.05753500387072563,
-0.18869683146476746,
-0.3547375500202179,
-0.38553571701049805,
1.1094369888305664,
0.3981151282787323,
0.2875889539718628,
-0.10475437343120575,
-0.12213870882987976,
0.022085290402173996,
0.4235907196998596,
-0.42454198002815247,
-0.002561950823292136,
-0.4911103844642639,
0.1271354705095291,
-0.435239315032959,
0.1281808763742447,
0.12051697820425034,
0.7809566259384155,
-0.39103150367736816,
-0.17959220707416534,
0.28985363245010376,
0.39047083258628845,
-0.4681098461151123,
0.027045106515288353,
0.40717843174934387,
0.5081652998924255,
-0.46601995825767517,
-0.7829521298408508,
0.38778263330459595,
0.05849243327975273,
0.13668718934059143,
-0.4389011263847351,
-0.3325587213039398,
-0.13782624900341034,
-0.251141756772995,
0.21003516018390656,
0.9195691347122192,
-0.3366559147834778,
-0.38378798961639404,
0.43874168395996094,
-0.44989535212516785,
-0.06077994033694267,
-0.21201655268669128,
-0.02371438778936863,
0.3786815106868744,
-0.44866299629211426,
-0.5064113736152649,
0.017811648547649384,
-0.22178497910499573,
0.69160395860672,
-0.4002218246459961,
0.5195191502571106,
-0.26743242144584656,
-0.3218109607696533,
-0.39310330152511597,
0.4869953989982605,
0.06722107529640198,
0.6146265864372253,
-0.20569182932376862,
-0.3730463981628418,
-0.24312809109687805,
0.25208669900894165,
0.06969167292118073,
-0.7022110819816589,
0.026468822732567787,
-0.5545725226402283
] |
multiple imputation for nonresponse in surveys is available in our book collection an online access to it is set as public so you can download it instantly. Our book servers hosts in multiple locations, allowing you to get the most less latency time to download any of our books like this one. Merely said, the multiple imputation for nonresponse in surveys is universally compatible with any devices to read. | [
0.016952598467469215,
-0.009302797727286816,
-0.0041702017188072205,
0.01896779052913189,
-0.006535613443702459,
-0.025923995301127434,
0.00940622016787529,
-0.004465305246412754,
-0.016387317329645157,
-0.016347171738743782,
-0.005378521978855133,
0.010234103538095951,
0.000835901009850204,
0.019949764013290405,
-0.03139004111289978,
0.03064359351992607,
-0.02027520351111889,
0.0040135858580470085,
0.012383876368403435,
0.018687499687075615,
0.029305350035429,
0.01655384711921215,
0.008678440004587173,
0.02587345615029335,
-0.016027620062232018,
0.032850492745637894,
-0.007136638276278973,
-0.010721963830292225,
0.004200438037514687,
-0.026976456865668297,
0.005505992565304041,
0.03422705456614494,
0.008007125928997993,
-0.0025285761803388596,
-0.0020188195630908012,
0.004274341277778149,
-0.009513624012470245,
0.019229896366596222,
0.00020374693849589676,
-0.005710653029382229,
0.0017408141866326332,
-0.0008011205354705453,
0.018054954707622528,
-0.010265624150633812,
-0.00423781992867589,
0.02109035663306713,
-0.012846588157117367,
0.03024081327021122,
-0.026144124567508698,
0.014488990418612957,
-0.003507891669869423,
-0.013475071638822556,
-0.014613280072808266,
-0.009851832874119282,
-0.0060042827390134335,
0.011655636131763458,
0.02009112946689129,
-0.008400268852710724,
0.005341192241758108,
-0.01797487959265709,
-0.008951090276241302,
0.00815911591053009,
-0.03192141652107239,
-0.02605394460260868,
-0.04031578078866005,
-0.06695934385061264,
0.01035987213253975,
0.015746941789984703,
0.009386551566421986,
-0.0010806790087372065,
0.009403301402926445,
0.017499182373285294,
0.008979723788797855,
0.0006175086018629372,
0.011341302655637264,
-0.0002853690821211785,
-0.012770050205290318,
-0.014414367265999317,
-0.00413926737383008,
-0.026548366993665695,
-0.0006887501804158092,
-0.005286368541419506,
-0.007836657576262951,
0.019683659076690674,
0.010252709500491619,
-0.005987165961414576,
-0.02722465805709362,
0.0024287451524287462,
0.01747921295464039,
0.021288849413394928,
-0.004069931339472532,
-0.03669751062989235,
-0.011164754629135132,
-0.0020229246001690626,
-0.03698088601231575,
0.028477884829044342,
0.01590156741440296,
0.039413709193468094,
0.031069960445165634,
-0.0028843979816883802,
-0.00538903521373868,
0.019386861473321915,
0.02149798348546028,
0.015659958124160767,
0.020969601348042488,
0.014304954558610916,
0.009746712632477283,
0.006688910070806742,
0.01137647032737732,
0.008885339833796024,
0.0042835804633796215,
-0.00501981982961297,
-0.031411346048116684,
0.039714470505714417,
0.02869168482720852,
0.045648932456970215,
0.007905470207333565,
0.022547436878085136,
0.01159623358398676,
0.009728504344820976,
-0.014763993211090565,
0.00846850499510765,
0.014653012156486511,
0.007713908329606056,
0.016379481181502342,
0.00945258792489767,
0.0024696234613656998,
-0.010101794265210629,
0.022672932595014572,
0.007420552894473076,
-0.009007650427520275,
0.016255324706435204,
-0.006536026019603014,
0.0029346628580242395,
0.030223116278648376,
-0.0012833456275984645,
0.005835398565977812,
-0.001806910615414381,
0.017302054911851883,
-0.015808695927262306,
-0.025859082117676735,
0.013351835310459137,
-0.0016382064204663038,
0.012510898523032665,
-0.007357885595411062,
-0.0061667063273489475,
-0.013132990337908268,
-0.006911067757755518,
-0.007155984174460173,
-0.00988928321748972,
0.011135227046906948,
0.009861967526376247,
-0.020610779523849487,
-0.019608883187174797,
0.0007826756336726248,
0.0065018292516469955,
-0.0006194789311848581,
0.010754680261015892,
-0.02298499271273613,
0.015586165711283684,
0.012665867805480957,
0.00647369772195816,
0.024273352697491646,
0.00812280923128128,
0.005076221656054258,
0.0016452176496386528,
0.006351876072585583,
-0.0009428663179278374,
0.004312621429562569,
0.004602841567248106,
-0.006000756751745939,
0.027844155207276344,
-0.002839378546923399,
-0.0025084801018238068,
0.02473394386470318,
-0.018692487850785255,
0.00037245338899083436,
0.006539988797158003,
-0.0016125929541885853,
0.06687118858098984,
0.0315803661942482,
-0.007601325865834951,
0.0013026529923081398,
-0.015355571173131466,
0.006844675168395042,
-0.016808755695819855,
-0.008018383756279945,
-0.0030205138027668,
-0.01981712505221367,
0.001786175649613142,
-0.01731063425540924,
-0.04379776120185852,
-0.01914239302277565,
0.0035744451452046633,
0.0009546965593472123,
0.0036118540447205305,
0.004673975054174662,
0.007178702857345343,
0.0035458665806800127,
0.0074067129753530025,
0.007840195670723915,
0.004976562224328518,
0.023416705429553986,
-0.008124317042529583,
-0.022154537960886955,
0.017216375097632408,
0.044711142778396606,
-0.015227974392473698,
0.013887058943510056,
0.005328861530870199,
0.018864303827285767,
0.02256307564675808,
-0.004374696407467127,
-0.03248882293701172,
-0.016249334439635277,
0.004346824251115322,
-0.024172931909561157,
-0.005456294398754835,
0.0030850982293486595,
-0.013939621858298779,
-0.0026224195025861263,
0.01207337062805891,
-0.011181525886058807,
-0.0001526487758383155,
0.01102908793836832,
0.011924750171601772,
0.0052465759217739105,
0.012539340183138847,
0.01845075935125351,
-0.010722269304096699,
-0.018102141097187996,
0.017855962738394737,
-0.010483461432158947,
-0.03088899329304695,
0.015125476755201817,
-0.001761782681569457,
0.006481484044343233,
-0.00836015585809946,
0.02289673313498497,
-0.014379682950675488,
0.013201075606048107,
-0.0176212377846241,
0.05177958309650421,
-0.011247757822275162,
0.021044714376330376,
-0.014140886254608631,
0.02136339619755745,
0.03889160975813866,
0.020146168768405914,
0.013393927365541458,
0.003996009938418865,
0.026355748996138573,
0.004546174313873053,
0.004061911720782518,
-0.022897740826010704,
0.007979901507496834,
-0.028195319697260857,
-0.004530689679086208,
0.025085823610424995,
0.026355383917689323,
-0.0011260401224717498,
0.0015400404809042811,
-0.007831408642232418,
-0.010301225818693638,
-0.00005319362026057206,
-0.00617679487913847,
-0.00593743147328496,
0.022781360894441605,
-0.015212306752800941,
-0.009294292889535427,
0.004514178726822138,
-0.007717974949628115,
-0.009303095750510693,
-0.0808815211057663,
-0.012743242084980011,
-0.017088958993554115,
0.03927960619330406,
0.008880961686372757,
-0.00122072861995548,
-0.01279456540942192,
0.010843522846698761,
-0.01578851044178009,
-0.01188763976097107,
-0.014119907282292843,
0.007934898138046265,
-0.02629683166742325,
0.03756001591682434,
-0.007077183108776808,
-0.0063461847603321075,
0.00964504387229681,
-0.0017195920227095485,
-0.0008089500479400158,
0.014535952359437943,
-0.012914491817355156,
-0.03154360502958298,
-0.004821381065994501,
0.012127024121582508,
0.005008045583963394,
-0.015421110205352306,
0.034044358879327774,
0.007524780463427305,
0.006014418788254261,
0.012285611592233181,
-0.01816478557884693,
0.012421687133610249,
0.012842506170272827,
-0.003257507923990488,
0.004495672881603241,
-0.015539976768195629,
-0.022983355447649956,
0.018724318593740463,
-0.0004721391305793077,
0.04485414922237396,
0.014456530101597309,
0.0033342428505420685,
0.02406027726829052,
-0.004226722288876772,
-0.005185853224247694,
0.013170790858566761,
-0.007178587839007378,
0.022481007501482964,
0.010041291825473309,
-0.006776830181479454,
0.02607152797281742,
-0.0029037706553936005,
-0.0033549664076417685,
0.01978752389550209,
-0.003309881780296564,
-0.010649079456925392,
-0.012957402504980564,
-0.008200038224458694,
-0.005436205305159092,
-0.010765609331429005,
0.006626331713050604,
0.00048427621368318796,
-0.020294541493058205,
0.05556169152259827,
-0.02942117117345333,
-0.01267923042178154,
0.003856456372886896,
0.005324332509189844,
-0.005582328885793686,
-0.00014100495900493115,
-0.011529299430549145,
0.017712295055389404,
0.0044569591991603374,
-0.00835300050675869,
-0.0028759625274688005,
-0.019169900566339493,
-0.01546030305325985,
-0.00125349429436028,
0.030824609100818634,
-0.00313456729054451,
-0.04091271385550499,
0.02814161218702793,
0.011398302391171455,
-0.002131412737071514,
-0.002677990822121501,
0.023549646139144897,
0.008146796375513077,
-0.026498794555664062,
0.008327429182827473,
-0.009394176304340363,
0.021388040855526924,
0.01565304957330227,
-0.035175446420907974,
0.005822780542075634,
-0.013286949135363102,
0.0003802728315349668,
-0.003887702478095889,
-0.014341188594698906,
-0.008587190881371498,
0.009662488475441933,
0.005635704379528761,
-0.021700449287891388,
-0.0036197900772094727,
-0.02021719142794609,
-0.0249127596616745,
0.013061067089438438,
-0.013462251052260399,
0.019246967509388924,
0.0008529337937943637,
-0.012366433627903461,
-0.00004745491241919808,
-0.006446240469813347,
-0.012159761972725391,
0.031752534210681915,
0.010722046718001366,
0.004936549812555313,
0.01815830171108246,
0.015609119087457657,
0.07160405069589615,
0.028425021097064018,
-0.0008983279694803059,
-0.017871364951133728,
0.0366082638502121,
-0.010928315110504627,
0.026546426117420197,
-0.0007617496885359287,
0.020980117842555046,
-0.000673266185913235,
0.013432069681584835,
-0.008167771622538567,
0.008370902389287949,
0.03651982173323631,
-0.0016299639828503132,
-0.014833024702966213,
-0.010916998609900475,
0.03091813251376152,
0.011610654182732105,
0.0517733134329319,
0.01634705625474453,
-0.027634333819150925,
0.017906030640006065,
-0.004576942417770624,
-0.003601101692765951,
-0.006210914812982082,
-0.00743586290627718,
-0.02062484435737133,
0.019045522436499596,
0.0012153958668932319,
-0.025374237447977066,
-0.007710258010774851,
-0.00882777851074934,
-0.020104890689253807,
0.021486196666955948,
-0.012006036937236786,
-0.028446730226278305,
-0.013977838680148125,
-0.003430470358580351,
0.0036598555743694305,
-0.013600009493529797,
-0.009319608099758625,
0.014162668958306313,
0.003253418253734708,
-0.03168167173862457,
0.0017350034322589636,
0.028291257098317146,
-0.0038252261001616716,
-0.017979126423597336,
0.014280369505286217,
0.004184200428426266,
0.02542067877948284,
0.015884902328252792,
0.035296522080898285,
-0.0179987084120512,
0.004195868503302336,
-0.009309918619692326,
-0.0008541698334738612,
0.03514258190989494,
0.028206326067447662,
-0.01013355515897274,
-0.006451824679970741,
0.01485154964029789,
0.03330550715327263,
-0.0012716170167550445,
-0.032692812383174896,
0.012583831325173378,
-0.0016697190003469586,
-0.0034490805119276047,
-0.02941669523715973,
-0.0003188946284353733,
-0.002946500899270177,
-0.0075181396678090096,
-0.010491308756172657,
-0.00860168319195509,
-0.026958459988236427,
-0.030948981642723083,
0.0018661967478692532,
0.015409608371555805,
-0.011782672256231308,
-0.015225107781589031,
0.001852104440331459,
-0.01098472997546196,
-0.013230754062533379,
0.0010476965690031648,
0.026909366250038147,
-0.024391788989305496,
-0.0742693692445755,
-0.015706529840826988,
0.007025733590126038,
-0.007302754558622837,
0.007555916905403137,
-0.021893475204706192,
-0.016415908932685852,
-0.004727954976260662,
0.012109377421438694,
-0.0016040158225223422,
0.0017005755798891187,
-0.006712039466947317,
-0.03359423577785492,
-0.009700420312583447,
0.008738888427615166,
-0.01057384256273508,
-0.005696495529264212,
0.006551602389663458,
-0.02427738532423973,
0.00922814104706049,
-0.009699344635009766,
-0.014256825670599937,
-0.0007817607256583869,
0.006598476320505142,
-0.017579328268766403,
-0.08045092225074768,
0.00381667772307992,
0.012196200899779797,
0.018781190738081932,
-0.023369787260890007,
-0.01675916276872158,
0.01447540707886219,
-0.019411340355873108,
0.012512877583503723,
-0.014608426950871944,
-0.02044259011745453,
0.023089883849024773,
-0.028042852878570557,
0.007164463400840759,
-0.0011943745194002986,
-0.0039133173413574696,
0.02399365045130253,
0.008589494973421097,
0.0033787295687943697,
-0.020514260977506638,
-0.01278576161712408,
-0.008328950963914394,
-0.0010277105029672384,
0.00899658352136612,
-0.008612592704594135,
0.0018827873282134533,
-0.014897475019097328,
0.01678283140063286,
-0.018873747438192368,
0.008176295086741447,
0.0234022606164217,
-0.0030001825653016567,
-0.015152402222156525,
-0.0014021489769220352,
-0.024298233911395073,
-0.0036483420990407467,
-0.007169896736741066,
0.0073228683322668076,
-0.0009253486641682684,
-0.017182504758238792,
0.0019816947169601917,
-0.00551516143605113,
-0.004794937092810869,
-0.0042387135326862335,
-0.007444457150995731,
-0.024939583614468575,
0.003532003378495574,
-0.00871978234499693,
0.023510873317718506,
0.013838897459208965,
0.006935293786227703,
0.004926145542412996,
0.03296835720539093,
-0.020653896033763885,
0.013239563442766666,
0.030578413978219032,
-0.01581510156393051,
0.037789810448884964,
-0.0038777680601924658,
0.018126819282770157,
-0.00786229781806469,
0.008640585467219353,
-0.005657433997839689,
0.07180752605199814,
-0.02629338577389717,
0.013787123374640942,
-0.007771972566843033,
-0.0029244825709611177,
-0.0023075812496244907,
-0.03225361555814743,
0.009678206406533718,
0.034782834351062775,
-0.015955746173858643,
0.0010295272804796696,
-0.01754048839211464,
0.008872615173459053,
0.009347552433609962,
0.010322701185941696,
-0.01373651996254921,
0.007488499395549297,
0.016161324456334114,
-0.013846281915903091,
-0.021308178082108498,
0.009146123193204403,
-0.0013795110862702131,
-0.000052523868362186477,
-0.008011315017938614,
0.03225547820329666,
-0.014382580295205116,
0.00980239175260067,
0.0013252666685730219,
-0.020613787695765495,
0.007439794018864632,
-0.006528530269861221,
0.03259167820215225,
0.002050034236162901,
0.008193076588213444,
0.017987754195928574,
-0.01158198993653059,
0.03402917459607124,
0.003619738854467869,
-0.004867903422564268,
-0.025687631219625473,
0.014689026400446892,
-0.0038476029876619577,
0.009257368743419647,
-0.011133875697851181,
-0.005502474028617144,
0.018878011032938957,
0.007258849684149027,
0.004380231723189354,
0.03194744512438774,
-0.0004353878030087799,
-0.009627191349864006,
0.0011686367215588689,
0.008107449859380722,
-0.005956050008535385,
0.00007817534060450271,
0.0027627733070403337,
-0.013211533427238464,
0.011969763785600662,
-0.011824747547507286,
-0.010431566275656223,
-0.02030513435602188,
-0.013890409842133522,
0.009566811844706535,
0.008677742443978786,
0.017104940488934517,
0.007198716979473829,
-0.0011237673461437225,
-0.012006125412881374,
-0.006225480232387781,
0.01728753000497818,
-0.019393807277083397,
-0.01888675056397915,
0.002826780779287219,
0.004047350492328405,
-0.004213961772620678,
-0.014512641355395317,
-0.03901633620262146,
-0.0008289788383990526,
0.0058797141537070274,
-0.00933266244828701,
-0.014487494714558125,
-0.0028520210180431604,
0.023204471915960312,
-0.034394752234220505,
0.008205016143620014,
0.022685475647449493,
0.025789091363549232,
0.013419662602245808,
-0.003469912800937891,
0.008354094810783863,
0.018232179805636406,
0.018684182316064835,
0.006705695763230324,
0.0070189558900892735,
0.007406916469335556,
0.035434260964393616,
-0.0069852350279688835,
0.016329048201441765,
0.01352149061858654,
0.014182979241013527,
0.0005980138666927814,
0.003568326821550727,
-0.015632208436727524,
0.02968938834965229,
-0.018086936324834824,
0.021203255280852318,
0.005254278425127268,
-0.006446152459830046,
-0.01632734388113022,
-0.020352406427264214,
-0.0037757274694740772,
-0.018129421398043633,
0.013021761551499367,
-0.00762338237836957,
0.01009981520473957,
0.010431372560560703,
-0.00356313050724566,
-0.01222520973533392,
0.01547536812722683,
-0.008405731990933418,
-0.006396204698830843,
-0.02155383490025997,
0.02067023515701294,
-0.003780444385483861,
0.004623072687536478,
-0.01991582103073597,
-0.01097242720425129,
0.01890168897807598,
0.0025156817864626646,
-0.0076461778953671455,
0.012082927860319614,
0.02288271300494671,
0.006908307783305645,
0.017848502844572067,
0.0025382069870829582,
-0.012121469713747501,
0.02362922765314579,
0.016109205782413483,
0.017501376569271088,
-0.014884622767567635,
0.02144313044846058,
-0.005447011906653643,
0.009689726866781712,
-0.014390246011316776,
0.011459078639745712,
0.01047223899513483,
0.018278062343597412,
0.02454322949051857,
-0.003277597250416875,
-0.011064203456044197,
-0.008265482261776924,
-0.0014819884672760963,
0.006530695594847202,
-0.005747504997998476,
0.014039209112524986,
0.01402889285236597,
0.00008018210792215541,
0.021287865936756134,
-0.011622931808233261,
0.012457575649023056,
-0.009171493351459503,
0.011937529779970646,
-0.0050835688598454,
0.018921418115496635,
-0.014756591059267521,
-0.03609906882047653,
-0.008717305958271027,
0.025307511910796165,
-0.011400124989449978,
0.02698412723839283,
-0.006604056805372238,
-0.01602545753121376,
-0.02306605689227581,
0.019220709800720215,
-0.003622085088863969,
-0.011659529060125351,
0.015325960703194141,
0.03458142653107643,
-0.008297198452055454,
0.01944289356470108,
-0.010761258192360401,
0.011745598167181015,
-0.003514082869514823,
-0.011476309038698673,
-0.01270579919219017,
0.03083150088787079,
-0.01858157105743885,
-0.02599988877773285,
0.004946970846503973,
-0.012887686491012573,
-0.0011908755404874682,
0.031098606064915657,
-0.02572966180741787,
-0.009643577970564365,
0.01657313108444214,
-0.011753402650356293,
-0.018781643360853195,
-0.008395262062549591,
-0.009313433431088924,
0.0105171799659729,
0.022189132869243622,
-0.018707212060689926
] | [
0.4701235890388489,
-0.24015702307224274,
0.42402538657188416,
0.6296358704566956,
-0.005356490146368742,
0.05971524864435196,
0.008592811413109303,
-0.04099876433610916,
-0.06067858263850212,
-0.265765905380249,
0.24994084239006042,
0.47977375984191895,
-0.12038206309080124,
0.09003609418869019,
-0.06688961386680603,
0.1849059909582138,
0.7129985094070435,
0.39053335785865784,
-0.27319031953811646,
-0.1886618435382843,
-0.20551565289497375,
-0.1748354732990265,
0.12542450428009033,
-0.7683566808700562,
-0.2752354145050049,
0.4072858691215515,
0.32698261737823486,
0.03456716239452362,
-0.9069275856018066,
-0.16869384050369263,
0.22977611422538757,
0.7725893259048462,
0.17109908163547516,
-0.1771271973848343,
0.22916698455810547,
-0.33312150835990906,
0.2528502643108368,
-0.3540153503417969,
0.12015462666749954,
-0.23537440598011017,
0.41285184025764465,
-0.20331719517707825,
-0.17638453841209412,
0.23014108836650848,
-0.16918548941612244,
-0.2733974754810333,
-1.7434003353118896,
-0.3074127435684204,
-0.5343145132064819,
0.3026197850704193,
-0.30063527822494507,
0.6845377683639526,
0.35806968808174133,
0.7422187924385071,
0.09652901440858841,
0.5948951244354248,
-0.529715895652771,
-0.3751544952392578,
0.2580902874469757,
-0.3247324228286743,
-0.010812525637447834,
-0.03836432471871376,
0.11233542114496231,
0.3566379249095917,
0.3288592994213104,
-0.2035844922065735,
0.3000786602497101,
0.4482727348804474,
-0.17176072299480438,
0.06716012209653854,
0.06138451397418976,
-0.2905377149581909,
-0.447576105594635,
0.23559708893299103,
-0.15893734991550446,
1.0039232969284058,
0.04691072553396225,
0.06558462977409363,
0.35544338822364807,
0.014879713766276836,
-0.029249029234051704,
0.276651531457901,
0.5592634081840515,
-0.23009319603443146,
0.5371374487876892,
-0.16802871227264404,
-0.09078703075647354,
0.38933083415031433,
0.23748983442783356,
0.223574697971344,
0.3085591495037079,
-0.2111847698688507,
0.16059044003486633,
0.05242598056793213,
0.7500423192977905,
0.07333960384130478,
0.28298354148864746,
-0.4218124449253082,
0.23010289669036865,
0.06434444338083267,
0.14543822407722473,
-0.15686118602752686,
0.5258095860481262,
-0.3075925409793854,
-0.35248294472694397,
-0.2611304819583893,
-0.2934264838695526,
-0.6852198839187622,
0.6243507862091064,
0.5121018290519714,
-0.4542009234428406,
1.0187041759490967,
-0.2182135432958603,
-0.1995592564344406,
-0.8960996866226196,
0.3791668117046356,
0.6235613226890564,
0.34283381700515747,
-0.4407908618450165,
0.3108636736869812,
-0.08222059160470963,
1.207128643989563,
0.7230114340782166,
0.09098616242408752,
0.5043898820877075,
0.12095528095960617,
0.4698828160762787,
0.3799656331539154,
-0.4021539092063904,
0.1550477147102356,
-0.014414170756936073,
0.5256720185279846,
0.4006436765193939,
-0.03574396297335625,
-0.07983816415071487,
-0.9413707852363586,
0.0023491880856454372,
-0.2194274365901947,
0.6297441124916077,
0.2803489863872528,
-0.339746356010437,
-0.34867745637893677,
-0.21005851030349731,
-0.31317177414894104,
0.0116385817527771,
0.30720463395118713,
-0.3068009316921234,
0.06177274510264397,
-0.3401903808116913,
-0.25469040870666504,
0.1994463950395584,
0.27585306763648987,
0.07444649934768677,
-0.4628670811653137,
-0.34211766719818115,
0.2704102396965027,
-0.18964910507202148,
0.12030496448278427,
-0.11083610355854034,
0.12033160030841827,
0.19415703415870667,
0.20316414535045624,
-0.5186066627502441,
0.18570800125598907,
-0.17947770655155182,
-0.15866385400295258,
-0.031869277358055115,
0.42759957909584045,
0.15619918704032898,
-0.3226795494556427,
-0.1293192058801651,
0.0926387682557106,
0.22391299903392792,
-0.5165303349494934,
0.09881120175123215,
0.3751271367073059,
0.37489745020866394,
0.5389918684959412,
0.5621159672737122,
-0.30260905623435974,
-0.5737736821174622,
-0.09770401567220688,
0.25107306241989136,
-0.6322072744369507,
0.1706613153219223,
0.017239324748516083,
0.5812609195709229,
0.04103969410061836,
0.012835168279707432,
0.014917566440999508,
-0.3360912799835205,
-0.2756716310977936,
0.08858564496040344,
-0.6373275518417358,
1.3299933671951294,
-0.034349001944065094,
-0.3382563292980194,
1.4176698923110962,
0.21286773681640625,
0.22566412389278412,
0.13509884476661682,
0.1286352276802063,
0.37280169129371643,
-0.08774257451295853,
-1.0067592859268188,
-0.29280439019203186,
-0.34287887811660767,
0.2033739686012268,
-0.05345383659005165,
-0.17981180548667908,
0.2670678198337555,
-0.010056305676698685,
-0.22870606184005737,
-0.23261572420597076,
-0.48457199335098267,
0.43626585602760315,
0.018241487443447113,
0.23113968968391418,
0.2240416705608368,
-0.10081640630960464,
1.1344064474105835,
-0.5202818512916565,
0.47514480352401733,
0.6180142164230347,
-0.2990301251411438,
0.5912821292877197,
0.2609504759311676,
0.49555376172065735,
0.4338158071041107,
-0.463767945766449,
-0.18593181669712067,
0.006323163863271475,
0.5937677025794983,
-0.6145232915878296,
0.1891511082649231,
0.14132477343082428,
0.013944307342171669,
-0.6603697538375854,
0.6413536667823792,
0.08586561679840088,
-0.15448403358459473,
-0.005326714366674423,
-0.1718166172504425,
0.30046918988227844,
0.18013545870780945,
0.12163261324167252,
-0.32657790184020996,
0.44153860211372375,
0.26692327857017517,
-0.3896855413913727,
0.5021505355834961,
0.3924626410007477,
0.08557429909706116,
-0.6915278434753418,
0.5990166068077087,
0.3875724673271179,
0.2142655849456787,
-0.18337108194828033,
0.28459206223487854,
0.19986645877361298,
-0.20510424673557281,
0.382099986076355,
-0.21229229867458344,
-0.06710704416036606,
-0.18318147957324982,
-0.8542699217796326,
-0.27047696709632874,
-0.3967704772949219,
0.15047284960746765,
0.23901186883449554,
-0.06385807693004608,
-0.13770674169063568,
-0.9245023727416992,
0.37793004512786865,
-0.18964876234531403,
-0.24467474222183228,
0.007263502571731806,
0.335842490196228,
-0.48939192295074463,
-0.5202364325523376,
0.07920265197753906,
0.3683055341243744,
0.4766228497028351,
-0.36597561836242676,
-0.28846997022628784,
-0.7279580235481262,
0.35657817125320435,
-0.27512216567993164,
-0.3087669014930725,
-0.24469727277755737,
-0.15973973274230957,
0.2685874104499817,
-0.024806959554553032,
-0.2737043797969818,
0.5057541131973267,
0.2576355040073395,
0.1032484769821167,
0.06383872777223587,
0.4085650146007538,
0.07703641802072525,
-0.24577170610427856,
0.016600362956523895,
-0.0523475743830204,
-0.09380108118057251,
0.312408983707428,
-0.43234214186668396,
-0.5784077644348145,
-0.059209831058979034,
-5.972214221954346,
-0.031214945018291473,
-0.9488287568092346,
0.28022468090057373,
-0.40427038073539734,
-0.01797991245985031,
0.7347008585929871,
-0.40162158012390137,
-0.11777898669242859,
0.11608552932739258,
0.08459492772817612,
0.5135084390640259,
0.42642974853515625,
0.24057282507419586,
0.2667371928691864,
0.19117093086242676,
0.5502430200576782,
0.2456149309873581,
0.1601875126361847,
0.3651355803012848,
-0.1022164523601532,
0.24848681688308716,
0.3526000380516052,
0.40586841106414795,
0.6777464747428894,
0.8233877420425415,
-0.5597108006477356,
0.17751318216323853,
0.06589911878108978,
-0.2734975516796112,
0.07245432585477829,
-0.17981819808483124,
-0.3574255108833313,
-0.3886297643184662,
-0.05921159312129021,
0.1793944388628006,
0.2379777729511261,
-0.05393180996179581,
-0.07882584631443024,
-0.01678212732076645,
0.4347899258136749,
0.0465664267539978,
0.4192323684692383,
-0.4561766982078552,
0.4230029582977295,
0.12709954380989075,
-0.37243974208831787,
0.07390806823968887,
-0.2589672803878784,
0.7063956260681152,
-0.1373731791973114,
-0.06389037519693375,
0.19557908177375793,
-0.10333673655986786,
-0.37663087248802185,
-0.22320646047592163,
0.2820793092250824,
0.3065994083881378,
-0.34276482462882996,
-0.18070998787879944,
0.060614317655563354,
-0.6156817674636841,
-0.3157941997051239,
-0.6332768201828003,
-0.7809398174285889,
0.10679194331169128,
-0.7121977210044861,
-0.3282625079154968,
0.7432885766029358,
0.46124130487442017,
-0.7426148653030396,
0.21480785310268402,
0.6360345482826233,
-0.5040632486343384,
0.6618874073028564,
0.005712737794965506,
-0.3286663591861725,
0.22499394416809082,
-0.5153223872184753,
0.41230282187461853,
-0.28711023926734924,
-0.5176820158958435,
-0.3556880056858063,
-0.14553476870059967,
0.5780182480812073,
-0.49939197301864624,
-0.3336154818534851,
-0.12714965641498566,
-0.2655850350856781,
-0.12268846482038498,
0.5080263018608093,
-0.5571300983428955,
0.2012736052274704,
0.1555345207452774,
0.6954631209373474,
0.8475750088691711,
0.3519357442855835,
0.3887941241264343,
0.1791374832391739,
-0.16272762417793274,
0.5982421636581421,
0.09929612278938293,
0.20833264291286469,
-1.3684097528457642,
-0.4528904855251312,
-0.01492086797952652,
-0.6563493609428406,
0.008869984187185764,
0.2455344796180725,
-0.6098830699920654,
-0.3612311780452728,
-0.633200466632843,
-0.4330050051212311,
-0.19381026923656464,
0.05885651335120201,
-0.15131409466266632,
0.09281691163778305,
0.20682880282402039,
0.2521522343158722,
-0.23574185371398926,
-0.055656205862760544,
0.16584689915180206,
-0.23454447090625763,
-0.47397294640541077,
-0.20705009996891022,
-0.31358104944229126,
-0.20111118257045746,
-0.04546758159995079,
-0.28533604741096497,
0.3105338513851166,
0.16580431163311005,
-0.03512190654873848,
-0.2738526463508606,
0.27139630913734436,
-0.009137425571680069,
-0.29242396354675293,
-0.15276362001895905,
0.20696108043193817,
-0.12589532136917114,
-0.25319206714630127,
0.2511144280433655,
-0.379054993391037,
-0.09511713683605194,
0.38553017377853394,
0.4029589891433716,
0.03378329798579216,
-0.14001727104187012,
-0.33679479360580444,
-0.30615806579589844,
0.03261331468820572,
-0.19103391468524933,
-0.477949857711792,
0.25182607769966125,
-0.19820886850357056,
0.29506179690361023,
0.24654150009155273,
0.275715172290802,
0.4422992467880249,
-0.1260589063167572,
-0.463815838098526,
-0.208338662981987,
-0.30868127942085266,
-0.9539846777915955,
0.07210566848516464,
0.22807879745960236,
-0.06324103474617004,
-0.8082919716835022,
0.20430970191955566,
-0.3230852782726288,
0.4771023988723755,
-0.3014996647834778,
-0.15941612422466278,
0.022619588300585747,
0.17991675436496735,
0.29704752564430237,
0.10253758728504181,
0.3368017077445984,
0.3102110028266907,
0.18466375768184662,
-0.14587652683258057,
-0.04656783491373062,
-0.454873651266098,
-0.08321662247180939,
0.3556852638721466,
0.9139158129692078,
-0.2946872115135193,
0.23544444143772125,
0.09588275104761124,
-0.22615237534046173,
-0.33074072003364563,
0.3380034267902374,
0.009908792562782764,
0.30343854427337646,
-0.47494104504585266,
-0.22688443958759308,
-0.7721221446990967,
0.31813186407089233,
0.21881456673145294,
-0.525144100189209,
0.07094612717628479,
0.16179531812667847,
0.5572683215141296,
-0.759496808052063,
0.37978655099868774,
0.011554698459804058,
-0.6329951882362366,
0.3327927589416504,
0.02435479685664177,
-0.2350318878889084,
0.4308583736419678,
-0.18379072844982147,
-0.23326259851455688,
-0.14158110320568085,
0.17521509528160095,
-0.1378941386938095,
0.11391128599643707,
-0.19113114476203918,
-0.2571926414966583,
-0.17216922342777252,
0.2515037953853607,
0.49289095401763916,
-0.21103981137275696,
-0.21439434587955475,
-0.2662718594074249,
-0.2555251717567444,
0.0932212695479393,
0.5656042695045471,
-0.6212027072906494,
-0.1153835654258728,
-0.0030081451404839754,
-0.014928219839930534,
-0.31361544132232666,
0.24801354110240936,
0.14808101952075958,
-0.19320783019065857,
-0.017055360600352287,
-0.2420748472213745,
0.08349228650331497,
0.11656317114830017,
-0.11426635086536407,
-0.31909313797950745,
0.1408643126487732,
-0.2262139767408371,
-0.6551267504692078,
-0.8859679698944092,
0.004876096732914448,
0.45117148756980896,
-0.46210458874702454,
-0.8272294402122498,
0.5226323008537292,
0.19977325201034546,
-0.5149568319320679,
0.02002524398267269,
-0.5327998995780945,
0.6604462265968323,
-0.04848924279212952,
-0.1276606172323227,
-0.5770297050476074,
-0.11599476635456085,
0.40658342838287354,
-0.02412712760269642,
-0.1426192820072174,
-0.6265685558319092,
-0.10016155987977982,
0.2632646858692169,
0.06605665385723114,
0.10355203598737717,
-0.6355024576187134,
0.285971462726593,
-0.8360093235969543,
-0.14478322863578796,
-0.022247865796089172,
0.018077632412314415,
0.23026247322559357,
-0.17515085637569427,
-0.1426595002412796,
-0.41210228204727173,
0.027210423722863197,
0.01985407993197441,
0.27500098943710327,
-0.028958123177289963,
-0.3794950246810913,
-0.0542990118265152,
-0.17272160947322845,
-0.013924673199653625,
0.29844900965690613,
0.1564495712518692,
0.1913122534751892,
0.225171759724617,
0.14663754403591156,
-0.22440816462039948,
0.23480947315692902,
-0.13525253534317017,
-0.22123245894908905,
0.10342956334352493,
0.08683231472969055,
0.27194368839263916,
0.1906716674566269,
-0.5843819379806519,
-0.5312293767929077,
0.043636683374643326,
0.12055844813585281,
0.7913011908531189,
-0.4153929352760315,
0.27331316471099854,
0.21729497611522675,
0.12191823124885559,
-0.053741518408060074,
-0.10581343621015549,
-0.14239618182182312,
0.43696025013923645,
-0.18082736432552338,
0.45097076892852783,
0.651088297367096,
-0.5015019774436951,
-0.2259128987789154,
-0.08018089830875397,
-0.1767255961894989,
0.2912199795246124,
-0.014757344499230385,
0.05614837631583214,
0.40997305512428284,
0.7392376065254211,
-0.4488643407821655,
-0.9226208329200745,
0.478762686252594,
-0.08769142627716064,
0.14014466106891632,
-0.15069110691547394,
-0.354944109916687,
0.4780445992946625,
0.4392332434654236,
-0.4071142077445984,
-0.2258165031671524,
0.15824158489704132,
-0.32628199458122253,
-0.144378200173378,
-0.17480409145355225,
-0.45848318934440613,
0.3385447561740875,
0.3906504213809967,
0.04430392012000084,
-0.08546386659145355,
0.30435582995414734,
-0.21969816088676453,
0.5296657681465149,
0.25299572944641113,
0.24650618433952332,
0.08466743677854538,
0.31201550364494324,
0.12232241034507751,
0.3849571645259857,
-0.2433948963880539,
-0.20431892573833466,
-0.49077895283699036,
-0.6609273552894592,
0.44953712821006775,
-0.5183324217796326,
0.04071853682398796,
-0.05683888494968414,
0.21471631526947021,
0.9524394273757935,
-0.8892180323600769,
0.04302116855978966,
-0.2347412258386612,
-0.3171556890010834,
1.5508414506912231,
0.11682914942502975,
0.104973204433918,
-0.14609083533287048,
-0.35257187485694885,
-0.022601427510380745,
-0.27900493144989014,
0.6737187504768372,
-0.1791522204875946,
-0.5289414525032043,
0.19967198371887207,
-0.009978695772588253,
0.20610544085502625,
0.4854273498058319,
-0.038055624812841415,
0.027281364426016808,
-0.19411443173885345,
-0.24885153770446777,
0.61780846118927,
-0.10623132437467575,
-0.026910346001386642,
-0.25909996032714844,
-0.03444153070449829,
-0.16694752871990204,
0.13178521394729614,
-0.5581169128417969,
-0.6569939851760864,
0.2253814935684204,
-0.3341166377067566,
-0.3080989718437195,
0.08460354804992676,
0.6547114849090576,
0.5248545408248901,
-0.12751376628875732,
0.11524462699890137,
-0.2747081518173218,
0.2765662968158722,
0.4166192412376404,
-0.45352253317832947,
0.4639908969402313,
-0.41913071274757385,
-0.3967519998550415,
-0.9013938903808594,
-0.14449238777160645,
0.559100866317749,
0.7090612649917603,
-0.3166600465774536,
-0.17976021766662598,
-0.19436340034008026,
-0.09535527974367142,
0.162087082862854,
-0.018978169187903404,
-0.06563533842563629,
0.13763050734996796,
-0.22952134907245636,
0.07945247739553452,
0.5582335591316223,
-0.08499438315629959,
0.05092041194438934,
-0.39404043555259705,
0.21489717066287994,
0.09787657856941223,
-0.22646422684192657,
0.3929422199726105,
-0.08221329003572464,
-0.4085234999656677,
-0.02755056880414486,
0.2542770504951477,
-0.43733301758766174,
0.1835295855998993,
-0.040404900908470154,
0.18785925209522247,
0.21551738679409027,
-0.700102686882019,
-0.3986752927303314,
0.005906139966100454,
-0.2930048704147339,
0.27102941274642944,
0.3072129189968109,
0.44701316952705383,
-0.08731204271316528,
-0.3107841908931732,
-0.5670483708381653,
0.16504615545272827,
-0.3781949579715729,
0.05429805815219879,
-0.019535189494490623,
-0.2972172796726227,
-0.5227696299552917,
0.05065656453371048,
-0.21358688175678253,
-0.009699342772364616,
-0.26833024621009827,
-0.029560718685388565
] |
Post-translational modification of chemokines mediated by the dipeptidyl peptidase DPP4 (CD26) has been shown to negatively regulate lymphocyte trafficking, and its inhibition enhances T cell migration and tumor immunity by preserving functional chemokine CXCL10. By extending those initial findings to pre-clinical models of hepatocellular carcinoma and breast cancer, we discovered a distinct mechanism by which inhibition of DPP4 improves anti-tumor responses. Administration of the DPP4 inhibitor sitagliptin resulted in higher concentrations of the chemokine CCL11 and increased migration of eosinophils into solid tumors. Enhanced tumor control was preserved in mice lacking lymphocytes and was ablated after depletion of eosinophils or treatment with degranulation inhibitors. We further demonstrated that tumor-cell expression of the alarmin IL-33 was necessary and sufficient for eosinophil-mediated anti-tumor responses and that this mechanism contributed to the efficacy of checkpoint-inhibitor therapy. These findings provide insight into IL-33- and eosinophil-mediated tumor control, revealed when endogenous mechanisms of DPP4 immunoregulation are inhibited. Eosinophils have been described mainly in allergy settings but are increasingly appreciated as being involved in other aspects of immunity. Albert and colleagues use a clinically approved inhibitor of the dipeptidyl peptidase DPP4 to facilitate the recruitment of eosinophils to mouse tumors, where they are essential in tumor destruction. | [
-0.017449619248509407,
0.01204521395266056,
-0.0077283307909965515,
0.008036415092647076,
0.012163251638412476,
-0.011854542419314384,
0.011192570440471172,
-0.000020423904061317444,
-0.011362157762050629,
-0.024303365498781204,
-0.016985885798931122,
0.0010976586490869522,
-0.01763007417321205,
0.00862473901361227,
-0.016423191875219345,
0.012146688997745514,
-0.008989064022898674,
0.0031975996680557728,
0.0063513340428471565,
-0.0011038845404982567,
0.0023855003528296947,
0.0031001721508800983,
0.010447460226714611,
-0.01012570969760418,
0.009224516339600086,
0.010026472620666027,
-0.01600913144648075,
-0.0014060339890420437,
-0.008747890591621399,
-0.008153628557920456,
-0.015412731096148491,
0.014421646483242512,
0.033273275941610336,
-0.0009105340577661991,
-0.003265011589974165,
-0.0005976324900984764,
-0.004813015460968018,
0.021822215989232063,
0.03133466839790344,
-0.005031513050198555,
-0.010557284578680992,
-0.01605641096830368,
-0.0003369751793798059,
-0.01081375777721405,
-0.007230622693896294,
-0.028631091117858887,
-0.0026449309661984444,
-0.005968856159597635,
-0.0021075818222016096,
0.007718369364738464,
-0.003479262813925743,
-0.012004449032247066,
-0.001603725366294384,
0.01502478402107954,
-0.006965167820453644,
0.004806969314813614,
0.01760002225637436,
-0.018322082236409187,
-0.003136581741273403,
-0.02506563998758793,
0.010329140350222588,
-0.02961118146777153,
0.001632927916944027,
-0.034603051841259,
0.034359969198703766,
-0.06718429177999496,
-0.017395710572600365,
0.0063056955114007,
-0.003656889544799924,
0.0016266313614323735,
0.0025862816255539656,
0.009843843057751656,
-0.01781642436981201,
-0.014529192820191383,
0.01133042760193348,
-0.01269107311964035,
-0.007607456296682358,
0.02927330881357193,
0.01641242206096649,
0.019208373501896858,
-0.0029358812607824802,
-0.016994941979646683,
0.021626506000757217,
0.024873537942767143,
0.028276007622480392,
-0.0043672057799994946,
-0.00884611252695322,
0.00384855130687356,
-0.0013898201286792755,
-0.006192980334162712,
0.01022002100944519,
0.014410778880119324,
-0.0019383872859179974,
0.002523845061659813,
0.00046798912808299065,
-0.004737399518489838,
-0.021862700581550598,
-0.018534500151872635,
0.00936107523739338,
0.004252021200954914,
-0.01314042042940855,
0.013031545095145702,
0.01435198076069355,
-0.012739022262394428,
0.023412343114614487,
0.004008171614259481,
-0.034454550594091415,
0.014728385955095291,
0.011825094930827618,
0.00938023254275322,
-0.018792349845170975,
0.026726216077804565,
0.01151110790669918,
0.035871658474206924,
0.007712955120950937,
-0.020536523312330246,
-0.007564540486782789,
-0.005193364806473255,
0.01726936548948288,
0.03613518178462982,
0.020810142159461975,
-0.00537527771666646,
-0.0010012438287958503,
0.021461153402924538,
0.005782131105661392,
0.00693939346820116,
-0.005914885085076094,
-0.00014744512736797333,
0.033942773938179016,
-0.0019188111182302237,
-0.006626340560615063,
0.00459341099485755,
-0.0013946755789220333,
0.005611849017441273,
0.013704189099371433,
-0.0007896700990386307,
-0.016522685065865517,
-0.0193924643099308,
0.004182664677500725,
0.001914725755341351,
-0.001961194910109043,
0.0024748845025897026,
-0.0008044581627473235,
0.01268736831843853,
0.016268203034996986,
0.007836182601749897,
-0.002663274994120002,
-0.011525859124958515,
-0.024915913119912148,
-0.00893694069236517,
-0.023218221962451935,
0.010742470622062683,
-0.0051086097955703735,
-0.013478816486895084,
0.005521127488464117,
0.007643198128789663,
-0.015214970335364342,
-0.014747938141226768,
-0.0031608836725354195,
-0.004583671223372221,
-0.018130654469132423,
-0.03687632083892822,
0.008484849706292152,
0.00955240335315466,
0.0061461590230464935,
-0.0009297928772866726,
-0.015052619390189648,
-0.003350519575178623,
-0.006739690899848938,
0.0077734352089464664,
-0.012525798752903938,
0.017474565654993057,
-0.022272396832704544,
0.007387196645140648,
0.011274543590843678,
-0.0028646409045904875,
0.00924171507358551,
0.006403390318155289,
-0.0048253764398396015,
0.06661125272512436,
0.005053658038377762,
0.004431079141795635,
0.022884320467710495,
-0.0027260701172053814,
-0.009587110951542854,
-0.02006368711590767,
0.018058128654956818,
-0.0016741857398301363,
0.010543283075094223,
-0.020342370495200157,
-0.01440744660794735,
0.006218092516064644,
-0.040256161242723465,
0.009556880220770836,
-0.03224368393421173,
0.002697309013456106,
0.013751750811934471,
0.013135452754795551,
-0.0012852861545979977,
0.01815292239189148,
0.02477717399597168,
-0.018066663295030594,
-0.006409736350178719,
-0.02318328619003296,
-0.0022208099253475666,
0.004569164477288723,
-0.0011384538374841213,
-0.007510692346841097,
-0.005691949278116226,
-0.02088111639022827,
0.01175056304782629,
-0.00031169713474810123,
0.006981219165027142,
0.010303753428161144,
-0.019301876425743103,
0.018981005996465683,
-0.021893594413995743,
0.023726364597678185,
-0.0024832577910274267,
-0.010084753856062889,
-0.004395261872559786,
0.01926496997475624,
0.03094937652349472,
-0.0014115252997726202,
0.043500058352947235,
-0.007975604385137558,
-0.0060122692957520485,
0.009740723296999931,
-0.005553190130740404,
-0.002816125052049756,
-0.012183811515569687,
-0.01681104674935341,
-0.01439283974468708,
0.03270707279443741,
0.006227149628102779,
0.0001837918534874916,
0.016212787479162216,
-0.024417579174041748,
0.018764670938253403,
-0.01705525815486908,
-0.015203513205051422,
-0.006012110970914364,
0.033200137317180634,
-0.016394292935729027,
0.021863918751478195,
-0.002298968844115734,
0.015642760321497917,
0.02517978847026825,
0.006774420849978924,
-0.004613939207047224,
0.010004449635744095,
0.004530245438218117,
0.005932836793363094,
-0.036548636853694916,
0.0024021603167057037,
-0.02297481894493103,
-0.02837160974740982,
-0.018751269206404686,
0.02575058676302433,
-0.012934578582644463,
0.003020674455910921,
0.006974257528781891,
-0.008665320463478565,
-0.02641403116285801,
0.006161958910524845,
0.009028162807226181,
0.0009723231196403503,
0.006435232236981392,
-0.008727828040719032,
0.018180014565587044,
0.010443335399031639,
-0.004826733376830816,
-0.004873733967542648,
-0.08190332353115082,
-0.013975588604807854,
-0.01390584371984005,
0.002155505120754242,
0.011160635389387608,
-0.021718883886933327,
-0.0030883480794727802,
-0.005242404527962208,
-0.007572056259959936,
-0.004165905527770519,
0.00902148149907589,
0.020978625863790512,
-0.007071696687489748,
0.0046070958487689495,
-0.014867478981614113,
-0.009066471830010414,
0.016108285635709763,
0.009247072972357273,
0.013364245183765888,
-0.039431460201740265,
0.012983889319002628,
0.009728669188916683,
0.015613850206136703,
-0.001110002165660262,
-0.02108973264694214,
0.038907330483198166,
0.01637989655137062,
0.006254856940358877,
-0.025341367349028587,
-0.001318065682426095,
-0.002880306215956807,
-0.0009754321072250605,
-0.008360709995031357,
-0.020448151975870132,
0.004760077688843012,
-0.0034977318719029427,
0.020843051373958588,
0.0007010363042354584,
-0.02208094298839569,
0.028969522565603256,
-0.017284967005252838,
-0.0006637974292971194,
0.01634972169995308,
0.014273609966039658,
0.015313932672142982,
0.0055998144671320915,
0.009425234980881214,
0.01564638689160347,
0.011101379059255123,
0.014989054761826992,
-0.005040028132498264,
0.01113146636635065,
-0.012359037064015865,
0.022385060787200928,
-0.0037935669533908367,
-0.020835498347878456,
-0.006721465382725,
0.0062359971925616264,
-0.012192673049867153,
-0.006786455400288105,
0.00042376876808702946,
-0.015143949538469315,
-0.004073600750416517,
0.00836322084069252,
-0.003586827777326107,
0.002665980951860547,
0.018166780471801758,
-0.008107678033411503,
-0.0013776281848549843,
0.0007695737294852734,
-0.0006822340656071901,
-0.014008091762661934,
-0.011238979175686836,
-0.004048890434205532,
0.00722156185656786,
-0.01059070322662592,
-0.012216759845614433,
-0.0143823754042387,
0.012643000110983849,
-0.02135574072599411,
-0.0019907853566110134,
0.004016769118607044,
-0.023649534210562706,
0.01873176544904709,
-0.013861089944839478,
-0.0017747590318322182,
0.009133853018283844,
0.02802182361483574,
0.010450159199535847,
-0.009540986269712448,
0.0007396736182272434,
-0.0010615759529173374,
0.009772886522114277,
0.010813310742378235,
0.009994376450777054,
-0.046038802713155746,
-0.0024963354226201773,
-0.000031553907319903374,
0.029386134818196297,
0.00908648781478405,
-0.019863944500684738,
0.0017562173306941986,
-0.0013768598437309265,
-0.007315669674426317,
-0.03374190628528595,
0.009280961006879807,
-0.005157950799912214,
0.0036756587214767933,
-0.019064635038375854,
0.004505248740315437,
-0.021348929032683372,
0.01885059103369713,
-0.0072129275649785995,
0.03636571019887924,
-0.00014550716150552034,
0.02065010741353035,
-0.00606030598282814,
-0.01066620647907257,
0.07246530055999756,
0.007366610690951347,
0.005271086003631353,
-0.002765074372291565,
0.010215356945991516,
-0.019085794687271118,
-0.012035820633172989,
0.008690724149346352,
-0.012925418093800545,
-0.009047138504683971,
0.01349617913365364,
0.006747253704816103,
0.02167968451976776,
0.009330999106168747,
0.00030824122950434685,
0.018184008076786995,
-0.029838819056749344,
0.011118201538920403,
0.03348720446228981,
-0.017111901193857193,
-0.013164045289158821,
-0.026184946298599243,
0.011342298239469528,
-0.0045151906087994576,
-0.007293942850083113,
0.005486033856868744,
0.02805441990494728,
-0.009886397048830986,
-0.01621166057884693,
0.012288520112633705,
-0.0061549837701022625,
-0.012959124520421028,
-0.010284392163157463,
0.009418617933988571,
-0.0083854915574193,
0.0077240075916051865,
-0.0012854791712015867,
-0.01956416666507721,
-0.010611329227685928,
-0.007296466268599033,
-0.009229649789631367,
-0.012717273086309433,
-0.02125922217965126,
-0.0009447699412703514,
-0.018297361209988594,
-0.005551207810640335,
-0.013657599687576294,
-0.007585455663502216,
0.011233551427721977,
-0.010534178465604782,
-0.012331860139966011,
-0.007860824465751648,
0.01901269145309925,
-0.00797114335000515,
-0.020592503249645233,
-0.0154330525547266,
-0.00792383961379528,
0.0021099024452269077,
-0.014671506360173225,
0.014346444979310036,
-0.023094620555639267,
0.0004515117034316063,
0.02350952848792076,
-0.030928073450922966,
0.01862160861492157,
0.0024931542575359344,
-0.008067620918154716,
-0.003169795498251915,
-0.001182303298264742,
0.017018087208271027,
0.006335114128887653,
-0.010007435455918312,
-0.02702275477349758,
0.00914500467479229,
-0.024853244423866272,
0.017609501257538795,
-0.02194966934621334,
-0.013014244846999645,
0.017498496919870377,
-0.012296376749873161,
0.006438529118895531,
0.02581600472331047,
0.002917385660111904,
-0.02200208604335785,
0.0003014868125319481,
0.0121432114392519,
-0.01293992716819048,
-0.07526516914367676,
-0.02431599423289299,
-0.011733032763004303,
-0.006098372861742973,
-0.010733723640441895,
0.008335250429809093,
-0.01984631083905697,
-0.01840837299823761,
0.00009310338646173477,
-0.004554123617708683,
-0.006654347293078899,
0.0037843622267246246,
-0.00935334898531437,
-0.015395806171000004,
0.013606511987745762,
0.02530006691813469,
0.003704449161887169,
0.000864940695464611,
-0.021449115127325058,
-0.005779851693660021,
0.0004934198223054409,
-0.023568086326122284,
-0.013283343985676765,
0.010186443105340004,
-0.01389279868453741,
-0.08118987083435059,
-0.006348184309899807,
-0.0019107726402580738,
-0.014342485927045345,
0.007444887422025204,
-0.019900280982255936,
0.01414952427148819,
-0.00928293913602829,
-0.03137383982539177,
-0.012850184924900532,
0.001832660287618637,
-0.003258552635088563,
-0.019918570294976234,
-0.00012200698256492615,
-0.01145150326192379,
-0.013085211627185345,
-0.006873142905533314,
-0.024086637422442436,
-0.01051492989063263,
-0.020135674625635147,
-0.006814355496317148,
-0.0018922551535069942,
-0.008337338455021381,
-0.034929677844047546,
-0.008504761382937431,
-0.027338378131389618,
-0.020876243710517883,
0.013631573878228664,
-0.012171567417681217,
-0.03791493922472,
-0.003911171108484268,
-0.03697372227907181,
-0.014374452643096447,
-0.03510752320289612,
-0.013181962072849274,
-0.021822843700647354,
-0.0018131397664546967,
0.00466366671025753,
0.007793298456817865,
-0.028010446578264236,
-0.0023130623158067465,
0.0311362873762846,
-0.007069794461131096,
0.004842577036470175,
0.0387297049164772,
0.022901978343725204,
0.0052679660730063915,
-0.00971781462430954,
0.009375395253300667,
-0.011691290885210037,
0.005150952376425266,
-0.016096094623208046,
-0.013188203796744347,
0.0027067088522017,
0.014175327494740486,
-0.006694127339869738,
-0.009267078712582588,
0.012122906744480133,
0.01759432442486286,
0.008814003318548203,
0.002287466311827302,
0.016652513295412064,
0.02001020312309265,
0.07166335731744766,
-0.014039174653589725,
0.01343202218413353,
-0.027938026934862137,
-0.003448684699833393,
0.004492221865803003,
0.0038172705098986626,
0.011253011412918568,
-0.024179760366678238,
-0.022197164595127106,
0.010337530635297298,
-0.0033310221042484045,
0.007283019833266735,
0.01138352882117033,
-0.027644027024507523,
0.0012089950032532215,
0.019246293231844902,
0.021418265998363495,
0.01582983508706093,
0.02188940718770027,
-0.009935075417160988,
0.002309769159182906,
-0.005697276908904314,
0.01478945929557085,
0.006938358303159475,
-0.025660956278443336,
-0.004179265350103378,
-0.028108105063438416,
0.0010960176587104797,
0.006865445524454117,
0.021101729944348335,
-0.001796472817659378,
-0.002191356383264065,
-0.003467103699222207,
0.015353049151599407,
0.033051226288080215,
-0.014101998880505562,
0.009995169006288052,
-0.016074655577540398,
-0.025756046175956726,
-0.025441564619541168,
0.014473522081971169,
0.00684730801731348,
-0.0030323669780045748,
-0.006928565911948681,
-0.011804361827671528,
-0.0009180938359349966,
0.014823956415057182,
-0.04431336373090744,
0.005132467485964298,
0.025669865310192108,
-0.0027080224826931953,
-0.012704096734523773,
-0.003876785049214959,
0.007014167495071888,
-0.011025875806808472,
-0.02525804005563259,
0.007371112704277039,
-0.017699366435408592,
-0.0062244962900877,
0.0164562426507473,
-0.009457321837544441,
0.0028462109621614218,
-0.02652899920940399,
0.02839413657784462,
-0.001780032180249691,
0.0025832438841462135,
-0.025361910462379456,
0.01118762232363224,
0.013312144204974174,
-0.023030411452054977,
-0.020269302651286125,
0.012379979714751244,
-0.006325806025415659,
0.01703248918056488,
0.022937458008527756,
0.0403466671705246,
0.010305759496986866,
0.022706395015120506,
0.002728298306465149,
-0.01186179555952549,
0.00651616370305419,
-0.005887551233172417,
0.016165591776371002,
-0.01692616567015648,
0.006327624432742596,
0.04130243882536888,
0.028162881731987,
0.0018655168823897839,
0.0097172437235713,
0.032595813274383545,
-0.014945682138204575,
-0.0011286322260275483,
0.00000498257577419281,
0.005711122415959835,
0.034450776875019073,
0.008729476481676102,
-0.003672325983643532,
-0.00042029237374663353,
0.0037655425257980824,
0.0014358418993651867,
-0.030550751835107803,
-0.01961700990796089,
0.01059430930763483,
-0.024683134630322456,
-0.0032207996118813753,
0.01278003677725792,
-0.012850528582930565,
0.00248055811971426,
0.004555324092507362,
-0.014926740899682045,
0.0078964214771986,
0.0034161314833909273,
0.01283470168709755,
0.009387851692736149,
0.015719272196292877,
-0.01760302484035492,
0.015158764086663723,
0.0034869788214564323,
-0.01571572944521904,
-0.013746418990194798,
0.00977577269077301,
-0.02505619451403618,
0.02948116697371006,
-0.024434998631477356,
-0.0016886463854461908,
-0.01734459027647972,
0.031436771154403687,
-0.011823564767837524,
0.0034084185026586056,
0.013642735779285431,
-0.012059589847922325,
-0.014452693983912468,
0.00040617305785417557,
0.009354623965919018,
0.032121848315000534,
-0.013930017128586769,
0.020640838891267776,
0.0077542588114738464,
0.01697671040892601,
0.010708490386605263,
-0.01127842627465725,
0.002416470553725958,
-0.019881172105669975,
0.00746656209230423,
-0.0018680779030546546,
0.021184325218200684,
0.020058952271938324,
0.009753232821822166,
-0.01544883381575346,
0.016820458695292473,
0.020101701840758324,
-0.01758057251572609,
-0.009558795019984245,
-0.0031916312873363495,
0.01899319887161255,
0.015833860263228416,
-0.016294531524181366,
0.015274765901267529,
-0.003579735290259123,
-0.017030874267220497,
-0.005816019140183926,
-0.012601327151060104,
-0.003931787330657244,
0.046658311039209366,
0.004186331294476986,
-0.006393998861312866,
0.009060941636562347,
-0.0002769550774246454,
-0.006816446781158447,
0.01116938516497612,
-0.007802431471645832,
-0.021115340292453766,
0.016731396317481995,
-0.022374192252755165,
0.003490007948130369,
-0.015393839217722416,
-0.013848154805600643,
0.02615797147154808,
0.012973366305232048,
0.012046366930007935,
-0.002985712606459856,
0.00813696626573801,
-0.003909556195139885,
-0.005203490611165762,
-0.012951178476214409,
-0.010811861604452133,
-0.019022289663553238,
-0.006707070395350456,
0.03561144694685936,
-0.010389557108283043,
-0.010180704295635223,
0.009265907108783722,
0.016475321725010872,
0.0020131664350628853,
-0.02308947779238224,
0.015863290056586266,
-0.012321539223194122,
-0.0006783893331885338,
-0.000004478730261325836,
0.03710728883743286,
-0.01298641785979271
] | [
0.21280333399772644,
-0.223155215382576,
0.21853159368038177,
0.3022106885910034,
-0.0477115660905838,
-0.10515794157981873,
0.052802663296461105,
-0.3173283040523529,
-0.46979543566703796,
-0.10992074012756348,
0.009180111810564995,
0.05899260193109512,
-0.4652853310108185,
0.29636073112487793,
0.02632283978164196,
0.9080637693405151,
0.22536487877368927,
0.25684693455696106,
-0.18844905495643616,
-0.8621811866760254,
0.10859483480453491,
-0.19487982988357544,
0.4160815477371216,
-0.1205722764134407,
0.14793306589126587,
0.011842083185911179,
0.5359804034233093,
0.10674232244491577,
0.287145733833313,
-0.3080560564994812,
-0.23047688603401184,
0.45548588037490845,
0.07758330553770065,
-0.06050615385174751,
-0.07223351299762726,
0.2552538514137268,
-0.43298134207725525,
-0.17320474982261658,
-0.2360691875219345,
-0.06972315162420273,
-0.43925583362579346,
-0.0955948755145073,
-0.3672056794166565,
0.29118478298187256,
0.15787072479724884,
-0.18980540335178375,
-0.8528613448143005,
0.73094642162323,
0.1854792982339859,
-0.042443402111530304,
-0.19756898283958435,
0.29108673334121704,
0.5061855316162109,
-0.16114939749240875,
0.6754116415977478,
0.08806056529283524,
-0.6584933400154114,
-0.30191144347190857,
0.2643011808395386,
-0.5279504060745239,
-0.17218300700187683,
0.03942098468542099,
-0.3159564733505249,
0.025787796825170517,
-0.04399280995130539,
0.5939024686813354,
-0.0025381993036717176,
-0.3643178641796112,
-0.6369315385818481,
-0.40184319019317627,
-0.006252895575016737,
-0.13540954887866974,
-0.1857055276632309,
0.2142740935087204,
-0.25215938687324524,
-0.23703216016292572,
-0.20942094922065735,
-0.16530866920948029,
0.3537359833717346,
0.028294265270233154,
0.32346847653388977,
-0.04491735249757767,
0.25343456864356995,
0.09835886210203171,
0.4121531546115875,
0.3988318145275116,
-0.1356002539396286,
0.6237360835075378,
-0.533687174320221,
-0.3526855409145355,
-0.2925146818161011,
0.20754294097423553,
0.19195562601089478,
0.42696234583854675,
0.021690404042601585,
0.2630675435066223,
-0.006816858891397715,
-0.035930830985307693,
-0.14133907854557037,
0.369187593460083,
-0.21931900084018707,
0.02078200876712799,
-0.08287462592124939,
-0.4315888285636902,
-0.4459710419178009,
-0.5702568888664246,
-0.20443448424339294,
-0.6909059286117554,
-0.9946366548538208,
0.4474491775035858,
-0.6065089702606201,
0.32662680745124817,
-0.5064866542816162,
-0.25444459915161133,
0.11534036695957184,
0.07086722552776337,
0.08123530447483063,
-0.1206556111574173,
0.09290038794279099,
0.19090351462364197,
0.030536595731973648,
1.581581711769104,
-0.15879333019256592,
0.5381132960319519,
0.15760624408721924,
-0.2754707634449005,
0.3096010386943817,
-0.5365601778030396,
-0.02885381132364273,
0.3684605658054352,
0.5861493349075317,
0.8580722808837891,
-0.5405832529067993,
0.031626515090465546,
-0.22178885340690613,
-0.029500126838684082,
0.5588371157646179,
0.26493534445762634,
0.13655775785446167,
0.06784655898809433,
-0.5428246855735779,
-0.4136788845062256,
-0.3921753764152527,
-0.2034379243850708,
-0.1741124391555786,
-0.05934759974479675,
-0.14327986538410187,
0.3492741882801056,
-0.03978446498513222,
-0.04408331960439682,
0.12322637438774109,
-0.1614655703306198,
-0.6585069298744202,
-0.09502354264259338,
-0.024018967524170876,
0.48817571997642517,
-0.09336536377668381,
-0.246922567486763,
0.14702358841896057,
0.12994779646396637,
0.32858946919441223,
-0.06492087990045547,
-0.13391034305095673,
0.010715899057686329,
0.6564144492149353,
-0.2678913474082947,
0.2252679169178009,
0.3025311827659607,
-0.09511347860097885,
-0.12621454894542694,
-0.51535564661026,
-0.353095144033432,
-0.21177972853183746,
-0.8258603811264038,
-0.15784434974193573,
-0.45112377405166626,
-0.10650357604026794,
-0.22228972613811493,
-0.07841545343399048,
0.3170425295829773,
-0.8728473782539368,
-0.17761358618736267,
-0.6480298638343811,
-0.6935829520225525,
0.08271318674087524,
0.4512551426887512,
0.8563768267631531,
0.033182770013809204,
0.06588796526193619,
0.2439243048429489,
-0.19092008471488953,
0.04495329037308693,
0.7792374491691589,
-0.3235253691673279,
1.5463624000549316,
-0.09009896218776703,
-0.26677748560905457,
1.2072025537490845,
0.27183297276496887,
0.16222019493579865,
-0.43349429965019226,
0.03674708679318428,
0.3056277930736542,
-0.15629395842552185,
-0.491814523935318,
0.008743861690163612,
0.0007392944535240531,
0.018758276477456093,
-0.1091679036617279,
0.5917345881462097,
0.13601583242416382,
-0.493426650762558,
-0.12998013198375702,
0.05349452421069145,
0.35119423270225525,
-0.739700198173523,
-0.015268773771822453,
-0.18053773045539856,
-0.702131986618042,
0.1731136590242386,
-0.18517668545246124,
-0.26343467831611633,
0.3025786876678467,
1.6362125873565674,
-0.3552565574645996,
1.008446455001831,
0.3040688633918762,
0.2647411525249481,
0.3202899098396301,
-0.25771403312683105,
0.31851229071617126,
-0.07290743291378021,
-0.03213205933570862,
-0.09675149619579315,
0.04883723333477974,
0.25603294372558594,
0.10411760956048965,
-0.2511844336986542,
-0.1256776750087738,
-0.13293777406215668,
-0.1050124391913414,
0.41241151094436646,
-0.3745187222957611,
0.14145630598068237,
-0.11043687164783478,
-0.17759382724761963,
-0.10286244004964828,
0.6788755655288696,
-1.1260327100753784,
-0.10917401313781738,
0.34956640005111694,
0.30583271384239197,
0.40970712900161743,
-0.6145692467689514,
0.045452263206243515,
0.09808196872472763,
-0.44929179549217224,
-0.7902166247367859,
-0.017238616943359375,
-0.6697323322296143,
0.032239463180303574,
0.20606966316699982,
0.1550336480140686,
0.09358343482017517,
0.3465840220451355,
0.02217358909547329,
-0.7676169276237488,
-0.13879431784152985,
0.9443341493606567,
0.5428628921508789,
0.5818015336990356,
-0.5717663168907166,
-1.047967791557312,
-0.2555725574493408,
-0.07915579527616501,
-0.10356952995061874,
-0.2195814847946167,
0.6869752407073975,
-0.30077481269836426,
-0.5024012923240662,
0.08153154700994492,
0.2752189636230469,
0.8646543025970459,
0.05786258354783058,
-0.6000760197639465,
0.020871758460998535,
-0.21441525220870972,
-0.5372068881988525,
-0.4376067817211151,
-0.44551849365234375,
0.15712323784828186,
0.09517635405063629,
-0.45504218339920044,
0.26788368821144104,
-0.010294301435351372,
0.20554973185062408,
-0.21607986092567444,
0.5731672048568726,
0.6179168820381165,
-0.0035529909655451775,
0.3319428265094757,
-0.1044207513332367,
-0.33919960260391235,
-0.01320685725659132,
-0.19789697229862213,
-0.20644190907478333,
-0.3520757555961609,
0.3566908836364746,
-5.8277482986450195,
0.0025058668106794357,
-0.14837533235549927,
-0.009200449101626873,
-0.0575665682554245,
0.039754468947649,
1.009315848350525,
0.0005268084350973368,
0.1127491295337677,
0.19005529582500458,
0.20518437027931213,
0.36678847670555115,
-0.3549865186214447,
-0.25372451543807983,
-0.1881353259086609,
0.06902480870485306,
0.18401768803596497,
-0.5369176864624023,
1.0816190242767334,
0.13287349045276642,
0.25201690196990967,
0.07076354324817657,
-0.24851690232753754,
0.22034798562526703,
-0.1750251054763794,
-0.22728510200977325,
-1.0749579668045044,
0.020660238340497017,
-0.33202287554740906,
-0.35532867908477783,
-0.11026729643344879,
-0.2145606279373169,
-0.31971660256385803,
0.11367393285036087,
0.5541526079177856,
0.07006105035543442,
-0.04740685224533081,
0.11691085994243622,
-0.2903594374656677,
-0.36401504278182983,
0.3827630877494812,
0.2832472324371338,
-0.3015572130680084,
0.2908894717693329,
0.38206732273101807,
0.02494822070002556,
-0.06633519381284714,
0.03615757077932358,
-0.6073386669158936,
0.6236827373504639,
-0.12243963032960892,
-0.36500874161720276,
0.17844028770923615,
0.7172852158546448,
0.509040117263794,
0.1209094375371933,
-0.42594051361083984,
-0.23167751729488373,
-0.6553604602813721,
0.3732679486274719,
-0.41134676337242126,
-0.10952653735876083,
-0.20280687510967255,
-0.5392547249794006,
0.10711579769849777,
0.2690495550632477,
-0.5319163203239441,
-0.6735865473747253,
0.5190026760101318,
-0.2020483762025833,
-0.2707013487815857,
0.23009566962718964,
0.3331422805786133,
-0.7544580698013306,
0.6002545356750488,
-0.2993714511394501,
0.05778693035244942,
0.1606956422328949,
-0.02841532602906227,
0.21782799065113068,
-0.460339218378067,
0.024565184488892555,
0.16778868436813354,
-0.06407060474157333,
0.22928813099861145,
-0.269012987613678,
-0.11691552400588989,
-0.02838941477239132,
-0.4085482358932495,
0.6290293335914612,
0.22986409068107605,
-0.18537749350070953,
-0.022763995453715324,
0.6518211960792542,
-0.49678292870521545,
0.4165292978286743,
0.11059195548295975,
0.319939523935318,
0.2681886553764343,
0.006876038387417793,
0.4263545870780945,
0.16942641139030457,
-0.528174877166748,
-0.5528737306594849,
0.07189392298460007,
0.10539902746677399,
-0.38840755820274353,
0.07805399596691132,
0.3520337641239166,
-0.553381621837616,
0.21584786474704742,
-0.04000333324074745,
-0.2593339681625366,
0.05678237974643707,
0.7856031060218811,
-0.2551133334636688,
-0.3660646080970764,
0.11687754839658737,
0.5712417364120483,
-0.4480557143688202,
0.3079395294189453,
0.25960972905158997,
-0.9670026898384094,
0.5311729907989502,
-0.03555968031287193,
-0.13951878249645233,
-0.06766834110021591,
0.7449619174003601,
-0.5509653687477112,
0.17435257136821747,
0.34860509634017944,
0.3656492531299591,
-0.31102362275123596,
-0.16163915395736694,
0.18125785887241364,
-0.6826962232589722,
-0.48469263315200806,
0.6921245455741882,
0.025210438296198845,
0.08522067964076996,
0.032656729221343994,
-0.2911002039909363,
-0.06515949964523315,
0.09306897222995758,
0.044583261013031006,
-0.13817262649536133,
0.27854210138320923,
0.4651853144168854,
-0.6194623112678528,
0.00890101958066225,
0.1845690757036209,
-0.31543129682540894,
0.16481012105941772,
0.20275387167930603,
0.45212501287460327,
-0.06915746629238129,
0.5735301375389099,
0.416628360748291,
0.6930395364761353,
-0.5447556376457214,
0.2653486728668213,
0.3558693528175354,
-0.9224528670310974,
0.27433741092681885,
-0.25714969635009766,
-0.17095299065113068,
-0.18214669823646545,
-0.5348791480064392,
0.0763043463230133,
-0.02422589622437954,
-0.4267770051956177,
-0.2874137759208679,
-0.2615030109882355,
-0.08736773580312729,
0.4742475152015686,
-0.11688816547393799,
-0.13211829960346222,
0.02518576756119728,
-0.14096225798130035,
-0.04509779438376427,
0.07860540598630905,
-0.5576688051223755,
-0.16978178918361664,
-0.006102512124925852,
0.3378318250179291,
0.014294201508164406,
-0.15717267990112305,
-0.41723597049713135,
0.27356991171836853,
-0.5726605653762817,
0.3701207637786865,
0.1707490235567093,
0.2121581733226776,
-0.09255805611610413,
0.08470088988542557,
0.17138925194740295,
0.4556790888309479,
0.4204510748386383,
-0.05102911219000816,
-0.879791796207428,
-0.09193284809589386,
0.8359413146972656,
0.02567044459283352,
0.32293689250946045,
0.4480045437812805,
0.21776127815246582,
-0.20777717232704163,
0.307995468378067,
-0.0736674964427948,
-0.23990003764629364,
-0.13533465564250946,
-0.5600647330284119,
0.19203124940395355,
0.10189690440893173,
0.10014539957046509,
-0.020028358325362206,
0.5437341928482056,
-0.3086298108100891,
-0.24254897236824036,
0.47736310958862305,
0.3403967320919037,
-0.3654446601867676,
-0.10203271359205246,
-0.3300832211971283,
-0.7015460133552551,
-0.14740248024463654,
0.2161107212305069,
-0.9495161175727844,
0.5650322437286377,
0.2774983048439026,
-0.015978848561644554,
-0.32691875100135803,
-0.22462491691112518,
0.10477078706026077,
-0.2154637575149536,
-0.4774896502494812,
-0.5962201356887817,
0.522149384021759,
0.187118262052536,
0.22164985537528992,
0.34340861439704895,
0.46133995056152344,
-0.0025613585021346807,
-0.11232108622789383,
0.021943120285868645,
0.7489824891090393,
0.061812687665224075,
-0.44107237458229065,
-0.229144886136055,
0.043230343610048294,
0.5148118138313293,
0.015639789402484894,
0.30985531210899353,
0.2147551029920578,
1.521726369857788,
0.11400848627090454,
0.0067898426204919815,
-0.19578851759433746,
-0.3635151982307434,
0.4138541519641876,
-0.44605544209480286,
0.44984573125839233,
-0.2904379963874817,
-0.1345309317111969,
-0.08346280455589294,
-0.013259048573672771,
0.22237782180309296,
-0.7935602068901062,
0.45945584774017334,
-0.11680856347084045,
-0.6468830108642578,
-0.2463744729757309,
0.665042519569397,
0.4560317099094391,
-0.24347686767578125,
0.34338560700416565,
-0.05470847338438034,
0.12759408354759216,
0.23554496467113495,
0.2040911763906479,
-0.13219617307186127,
-0.4559243619441986,
0.3650357127189636,
-0.6928069591522217,
0.5700910091400146,
-0.5722351670265198,
-0.09469231218099594,
-0.3785856068134308,
0.1809338480234146,
-0.38013964891433716,
-0.2874438464641571,
0.1594683676958084,
-0.4489922523498535,
-0.4708865284919739,
-0.08970731496810913,
0.23997312784194946,
-0.13533665239810944,
0.08783169090747833,
0.2709839940071106,
-0.178948312997818,
-0.38514411449432373,
0.2966345548629761,
0.8687801361083984,
-0.02488962560892105,
-0.5744495391845703,
0.23042936623096466,
0.2258133441209793,
0.08299451321363449,
-0.46746429800987244,
0.21547292172908783,
-0.06858518719673157,
-0.0025046993978321552,
0.4630098044872284,
-0.07147146761417389,
-0.3133539855480194,
0.2797049283981323,
-0.08802157640457153,
0.20077234506607056,
0.12928694486618042,
0.23849238455295563,
0.30811163783073425,
0.44145509600639343,
0.4551731050014496,
-0.15411987900733948,
-0.03528006374835968,
-0.0064467317424714565,
0.23620013892650604,
0.23497508466243744,
0.16222934424877167,
0.6044389009475708,
0.22133615612983704,
0.23925408720970154,
0.047219205647706985,
0.9210208058357239,
0.5988190174102783,
0.42459380626678467,
0.2819448411464691,
-0.30384132266044617,
-0.3757762014865875,
-0.47803619503974915,
0.5410687923431396,
0.3830905556678772,
-0.3015153110027313,
0.12492582947015762,
0.5347735285758972,
0.22566838562488556,
0.16951899230480194,
-0.2673817574977875,
-0.4109056293964386,
0.6164571046829224,
0.3029657006263733,
-0.09049477428197861,
-0.6431090831756592,
0.30213749408721924,
-0.9011317491531372,
0.4517236053943634,
0.8478076457977295,
-0.1298767477273941,
-0.5381157994270325,
0.2557431161403656,
-0.5249889492988586,
-0.2294095754623413,
-0.29457202553749084,
0.845666229724884,
0.09283985942602158,
-0.17834769189357758,
0.36602598428726196,
0.09336114674806595,
0.39844268560409546,
-0.14528107643127441,
-0.08935022354125977,
-0.07489506900310516,
-0.009661057963967323,
0.1608257293701172,
0.3351741433143616,
-0.49908447265625,
-0.08760353177785873,
-0.42361339926719666,
0.013381021097302437,
0.586432933807373,
-0.25645411014556885,
0.24448207020759583,
-0.604673445224762,
-0.46121230721473694,
-0.6340855360031128,
-0.1468593180179596,
-0.7277001142501831,
-0.01472232211381197,
0.056530941277742386,
0.056927505880594254,
0.13708190619945526,
-0.49071383476257324,
0.06242495775222778,
0.23287130892276764,
0.06410783529281616,
0.3355104625225067,
-0.19685496389865875,
0.31487178802490234,
0.03080235794186592,
0.4621814787387848,
0.10864805430173874,
0.3978438079357147,
-0.22129780054092407,
0.5956026911735535,
-0.42863085865974426,
0.5049077868461609,
-0.794983446598053,
0.17157557606697083,
-0.47395139932632446,
-0.41040265560150146,
0.6655355095863342,
0.8528270721435547,
-0.37447407841682434,
0.18898777663707733,
0.3211042284965515,
0.16229815781116486,
0.4085206687450409,
-0.6933622360229492,
-0.31305992603302,
-0.5724806785583496,
-0.2529803216457367,
-0.36752986907958984,
0.7240439653396606,
0.04010201618075371,
-0.4499845504760742,
-0.04885118082165718,
0.4972209334373474,
0.07689504325389862,
-0.16168689727783203,
0.1872887909412384,
-0.1547541320323944,
-0.19237880408763885,
-0.6411088109016418,
0.2790374457836151,
-0.4671732187271118,
0.11779215186834335,
-0.48898816108703613,
0.4627271890640259,
0.17057164013385773,
-0.14663270115852356,
0.09239603579044342,
-0.23780374228954315,
0.17254996299743652,
-0.3483775556087494,
0.14108072221279144,
-0.4209417998790741,
-0.42279481887817383,
-0.9004368185997009,
-0.3243453800678253,
0.19221214950084686,
0.5488792061805725,
-0.062288638204336166,
-0.37370702624320984,
0.25186672806739807,
0.4030078053474426,
-0.17980647087097168,
-0.11440341919660568,
-0.428209125995636,
-0.0642734244465828,
0.16692344844341278
] |
Glioblastoma multiforme (GBM) is a fatal malignancy of the central nervous system, commonly associated with chemoresistance. The alkylating agent Temozolomide (TMZ) is the front-line chemotherapeutic agent and has undergone intense studies on resistance. These studies reported on mismatch repair gene upregulation, ABC-targeted drug efflux, and cell cycle alterations. The mechanism by which TMZ induces cell cycle arrest has not been well-established. TMZ-resistant GBM cells have been linked to microRNA (miRNA) and exosomes. A cell cycle miRNA array identified distinct miRNAs only in exosomes from TMZ-resistant GBM cell lines and primary spheres. We narrowed the miRs to miR-93 and -193 and showed in computational analyses that they could target Cyclin D1. Since Cyclin D1 is a major regulator of cell cycle progression, we performed cause-effect studies and showed a blunting effects of miR-93 and -193 in Cyclin D1 expression. These two miRs also decreased cell cycling quiescence and induced resistance to TMZ. Taken together, our data provide a mechanism by which GBM cells can exhibit TMZ-induced resistance through miRNA targeting of Cyclin D1. The data provide a number of therapeutic approaches to reverse chemoresistance at the miRNA, exosomal and cell cycle points. | [
0.007586867548525333,
-0.005431176163256168,
0.0028503555804491043,
0.0018181647174060345,
-0.008134542964398861,
0.004275286570191383,
0.01179638784378767,
0.005322623997926712,
-0.007285785395652056,
-0.007494371384382248,
-0.02189807966351509,
0.004581098910421133,
0.005434044171124697,
0.005039408337324858,
-0.004173034802079201,
0.00836328323930502,
-0.016606708988547325,
0.029210811480879784,
0.017793454229831696,
0.024562131613492966,
0.003781863721087575,
-0.005114986095577478,
0.009426185861229897,
-0.010453624650835991,
0.039712369441986084,
0.02804853580892086,
-0.02047884464263916,
-0.008329404518008232,
-0.02698039636015892,
0.0113146360963583,
-0.007381591945886612,
0.014385389164090157,
0.03801105171442032,
-0.0021719224750995636,
0.011303611099720001,
-0.02070004865527153,
-0.006059593521058559,
0.024465369060635567,
0.005518054589629173,
-0.005518555175513029,
0.020152147859334946,
-0.012628811411559582,
0.002355356467887759,
-0.028688067570328712,
-0.009498851373791695,
0.00571031030267477,
0.002384650520980358,
-0.0024201776832342148,
-0.0007590721361339092,
0.012500975281000137,
-0.004758867435157299,
-0.026189139112830162,
-0.0051898472011089325,
0.028282377868890762,
-0.006114874500781298,
-0.0008896674262359738,
0.016711272299289703,
-0.02088935673236847,
-0.017535492777824402,
0.005341095384210348,
0.003870823886245489,
-0.019182339310646057,
-0.007985617965459824,
-0.015699252486228943,
-0.0056051523424685,
-0.06712296605110168,
0.037187814712524414,
-0.004900230560451746,
-0.00315582612529397,
0.004950359929352999,
0.00770871527493,
0.010862075723707676,
0.01756693422794342,
-0.02706291899085045,
0.019098743796348572,
-0.0035512899048626423,
-0.0124679459258914,
0.014813488349318504,
0.004340250976383686,
0.027244463562965393,
-0.006073326338082552,
-0.021657485514879227,
-0.009053223766386509,
0.022347528487443924,
0.004021140281111002,
-0.00908906850963831,
-0.02431727573275566,
-0.030876003205776215,
-0.008312730118632317,
0.006541126873344183,
0.005698974244296551,
-0.004369729198515415,
-0.008216220885515213,
0.005394065286964178,
-0.008507180027663708,
-0.01047117542475462,
-0.0028199253138154745,
-0.009709810838103294,
-0.021309176459908485,
-0.009962394833564758,
0.00045596680138260126,
0.013897632248699665,
0.011291053146123886,
0.017607878893613815,
0.013194598257541656,
-0.00023048202274367213,
-0.0007582746911793947,
-0.0021243086084723473,
-0.004806761164218187,
0.014815058559179306,
0.0030471072532236576,
0.022495707497000694,
-0.020509157329797745,
-0.004205483943223953,
0.017381951212882996,
0.020039213821291924,
-0.022449232637882233,
-0.025154095143079758,
0.0058817071840167046,
0.030916133895516396,
0.02391337975859642,
0.006540144793689251,
-0.00015025539323687553,
-0.004951137118041515,
0.0022815708070993423,
-0.010717211291193962,
0.0068088858388364315,
-0.019591720774769783,
0.016468871384859085,
0.00433964841067791,
-0.005876976530998945,
0.012332599610090256,
0.01822715997695923,
-0.0031796302646398544,
-0.020331144332885742,
-0.00797361508011818,
-0.02319108322262764,
-0.006213296204805374,
-0.0068729231134057045,
-0.00733002508059144,
-0.007309898734092712,
0.005812861490994692,
0.006456264294683933,
0.01003679446876049,
0.01621486246585846,
-0.001756600453518331,
-0.016303110867738724,
0.000981300720013678,
-0.01904839091002941,
-0.025195853784680367,
-0.015914998948574066,
-0.015349235385656357,
-0.027095340192317963,
-0.001023628981783986,
0.00100348936393857,
-0.006030915770679712,
-0.012600391171872616,
-0.019188810139894485,
-0.0017737235175445676,
0.0015946963103488088,
-0.00760031258687377,
-0.016203202307224274,
0.00742740323767066,
0.007635942194610834,
0.011195268481969833,
-0.018557682633399963,
-0.007007482927292585,
-0.011381641030311584,
0.008698186837136745,
0.008547581732273102,
-0.01199791394174099,
-0.01806735061109066,
0.036703966557979584,
0.008590007200837135,
-0.0012646140530705452,
0.0021832436323165894,
0.018712243065238,
0.006507125683128834,
-0.004685322288423777,
0.06676415354013443,
-0.015250809490680695,
0.000938721583224833,
0.005740996450185776,
-0.020819727331399918,
0.014490287750959396,
-0.0106110330671072,
0.0004008607938885689,
-0.005091029219329357,
-0.02856576442718506,
0.0026990834157913923,
0.0027151405811309814,
-0.0004921457730233669,
-0.017127923667430878,
0.010109705850481987,
-0.00813420582562685,
0.0029730519745498896,
0.01789017580449581,
0.007695858366787434,
0.019129175692796707,
0.01950392872095108,
0.03396204859018326,
-0.0233609639108181,
0.0029309457167983055,
-0.003397576278075576,
0.05165819823741913,
-0.0015517114661633968,
0.0017232189420610666,
-0.018735570833086967,
-0.012519918382167816,
-0.00704684853553772,
0.008131565526127815,
-0.000751986401155591,
-0.007636999245733023,
-0.002781245158985257,
-0.017491331323981285,
-0.008679808117449284,
-0.008535990491509438,
0.02699900232255459,
0.0133374547585845,
-0.006078807637095451,
-0.014822917059063911,
-0.01818912848830223,
-0.031474705785512924,
-0.02429600991308689,
0.04112646356225014,
0.001467901049181819,
0.007834689691662788,
0.008334319107234478,
-0.0024581006728112698,
0.008865096606314182,
0.005400381051003933,
-0.01572320982813835,
-0.016343459486961365,
0.023388339206576347,
-0.01700129732489586,
0.004780549090355635,
0.013662127777934074,
-0.017636461183428764,
0.006755692884325981,
-0.015615975484251976,
0.03418833762407303,
0.003087654709815979,
-0.0029764564242213964,
0.00493332976475358,
-0.007891612127423286,
-0.0017233937978744507,
0.025166194885969162,
0.021871406584978104,
-0.0024928469210863113,
-0.0048628030344843864,
0.010277606546878815,
0.0019511819118633866,
-0.020157979801297188,
-0.016096770763397217,
0.005592229310423136,
-0.002964853774756193,
0.0070130182430148125,
-0.00840332917869091,
0.02508777752518654,
-0.011140127666294575,
0.010338498279452324,
0.00877144280821085,
-0.00642178300768137,
-0.016277983784675598,
-0.013648724183440208,
0.01333574764430523,
0.03607060760259628,
0.023268267512321472,
-0.026090070605278015,
0.04402719438076019,
0.006201921030879021,
0.0016712164506316185,
-0.004007161129266024,
-0.0817137062549591,
-0.005689313169568777,
-0.00789094902575016,
0.004257485270500183,
0.0017158410046249628,
0.027620304375886917,
-0.008256049826741219,
-0.000537295825779438,
-0.011743884533643723,
-0.01369590125977993,
0.006949851289391518,
-0.011549836955964565,
-0.011993903666734695,
-0.005247973371297121,
0.01117299497127533,
-0.01311043743044138,
0.01233005803078413,
0.009636839851737022,
0.005512895993888378,
-0.05197376385331154,
-0.00175442174077034,
0.006381949409842491,
0.02849612757563591,
0.00816935021430254,
-0.01707490347325802,
-0.003454136196523905,
0.016513705253601074,
0.004114110488444567,
-0.0066692885011434555,
0.007220449857413769,
-0.017134223133325577,
0.014643179252743721,
-0.020830348134040833,
-0.013102411292493343,
-0.00203905813395977,
-0.008677775040268898,
-0.009573131799697876,
0.014569113962352276,
-0.002913491567596793,
0.005877593066543341,
-0.01316104643046856,
-0.0015201324131339788,
0.004715254530310631,
-0.016861984506249428,
0.010820697993040085,
0.01758476532995701,
-0.03819052129983902,
-0.00589752709493041,
0.01333688385784626,
-0.0013368995860219002,
-0.020746920257806778,
0.01444005686789751,
0.02744956873357296,
0.02344460040330887,
-0.017621388658881187,
-0.00967307947576046,
-0.012877993285655975,
0.004506275989115238,
-0.01242149155586958,
-0.015526074916124344,
0.011339481920003891,
-0.04016897827386856,
0.004495575092732906,
0.032077521085739136,
-0.017767326906323433,
-0.006073745433241129,
0.014287792146205902,
0.0009634388843551278,
-0.028541337698698044,
-0.00855070911347866,
-0.019331924617290497,
0.00035539339296519756,
-0.041034746915102005,
-0.0036388556472957134,
-0.03481026738882065,
-0.005999291315674782,
-0.014105337671935558,
-0.0018964055925607681,
0.007600333541631699,
-0.013311998918652534,
-0.006423237267881632,
0.018505139276385307,
-0.0003394444938749075,
0.0070009296759963036,
-0.004674553871154785,
-0.026403037831187248,
0.007159798871725798,
0.011955918744206429,
0.01124718226492405,
-0.010819043032824993,
-0.0014191493391990662,
0.03305482491850853,
-0.027916699647903442,
0.012097092345356941,
0.009450456127524376,
0.0005521802231669426,
-0.00853174738585949,
0.02249736338853836,
0.03200965374708176,
0.007759140804409981,
0.008242467418313026,
-0.00815434381365776,
0.005036256276071072,
-0.009854067116975784,
-0.034229576587677,
0.017891595140099525,
0.010746271349489689,
-0.008706066757440567,
-0.008052542805671692,
-0.004249432124197483,
-0.015124211087822914,
0.012658665888011456,
-0.003953484818339348,
0.03544577211141586,
0.016948148608207703,
0.01137327216565609,
-0.001867963932454586,
0.003971522208303213,
0.07207582890987396,
-0.0026684466283768415,
-0.007362957112491131,
-0.021898262202739716,
0.012571960687637329,
-0.022580331191420555,
-0.0003742785193026066,
0.03455917537212372,
-0.01611272059381008,
-0.005672303494066,
0.012778199277818203,
-0.012351157143712044,
0.04325880482792854,
-0.018477950245141983,
-0.007247764617204666,
0.02534603141248226,
0.007444862276315689,
0.013013606891036034,
-0.004070451017469168,
-0.027415115386247635,
0.008834749460220337,
-0.03372044861316681,
-0.017117362469434738,
0.004097796976566315,
-0.0069646649062633514,
0.008412162773311138,
0.02276977151632309,
-0.013220010325312614,
-0.013969754800200462,
0.015185004100203514,
0.008851878345012665,
-0.01091491337865591,
-0.012321227230131626,
0.012309696525335312,
0.0017479258822277188,
-0.015135861933231354,
0.0005754684098064899,
0.019333407282829285,
0.010872887447476387,
0.003313422203063965,
-0.0026636505499482155,
-0.017548054456710815,
0.01456458866596222,
0.017651639878749847,
-0.012884113937616348,
-0.0041140904650092125,
0.036540210247039795,
-0.005295568145811558,
-0.0007040894706733525,
-0.014341279864311218,
0.0057435426861047745,
0.010094624012708664,
0.008395729586482048,
0.0158836767077446,
-0.00004458148032426834,
-0.012134701944887638,
0.016611233353614807,
-0.0034399679861962795,
0.014351842924952507,
0.004445657134056091,
0.01930694468319416,
0.0035660164430737495,
0.024731889367103577,
0.007839770056307316,
0.016248049214482307,
-0.010822625830769539,
0.011402798816561699,
0.009423458017408848,
0.006274827755987644,
-0.0077242180705070496,
0.027867775410413742,
-0.03108062781393528,
-0.02403702586889267,
0.012621709145605564,
-0.02188526839017868,
0.0200661513954401,
-0.025596292689442635,
-0.0016165617853403091,
0.010592663660645485,
0.017101969569921494,
-0.02349061891436577,
-0.004953457973897457,
0.012316182255744934,
0.00758002232760191,
0.00263012177310884,
0.01123025082051754,
-0.019169554114341736,
-0.07451088726520538,
-0.003094715066254139,
-0.0002323952503502369,
-0.001032068976201117,
0.007029148284345865,
-0.027574121952056885,
-0.009655872359871864,
-0.0011255033314228058,
0.0019250642508268356,
0.00009448861237615347,
-0.011842107400298119,
0.0037312936037778854,
0.0021977885626256466,
0.007898379117250443,
0.009843356907367706,
0.007507043890655041,
0.000010116025805473328,
-0.008798069320619106,
-0.010802550241351128,
0.004598056897521019,
-0.041742078959941864,
0.009190165437757969,
0.015694160014390945,
0.020627271384000778,
-0.007460662163794041,
-0.08079102635383606,
0.020683109760284424,
-0.006289999466389418,
-0.0010484722442924976,
-0.007294755429029465,
-0.0018097094725817442,
-0.02185788005590439,
-0.016230570152401924,
-0.03292214870452881,
-0.014998705126345158,
0.02836860530078411,
0.01667313650250435,
-0.02539438009262085,
-0.0012467209016904235,
-0.004944090731441975,
-0.018790477886795998,
0.01564263366162777,
-0.004227173514664173,
-0.008782986551523209,
0.005055148620158434,
0.010930726304650307,
-0.003329749219119549,
-0.005489135626703501,
-0.016401685774326324,
-0.0055009895004332066,
0.010846493765711784,
0.006267043761909008,
0.014697322621941566,
-0.004747234284877777,
0.011327581480145454,
0.026183661073446274,
-0.0021269465796649456,
0.005340855568647385,
-0.023991994559764862,
-0.003609866602346301,
-0.017465803772211075,
-0.0036997348070144653,
0.006202894262969494,
-0.017548315227031708,
-0.017610600218176842,
-0.007550038397312164,
0.026930559426546097,
-0.0017287671798840165,
-0.009568095207214355,
-0.0013180244714021683,
0.011373702436685562,
0.007911013439297676,
-0.008404583670198917,
0.0027460127603262663,
0.036581266671419144,
0.0015335549833253026,
-0.023044416680932045,
0.026331769302487373,
0.01646096631884575,
-0.007716958411037922,
-0.015572184696793556,
-0.0013500218046829104,
0.003673028899356723,
-0.003253028728067875,
0.012761379592120647,
-0.007232568226754665,
0.01979352906346321,
0.025850357487797737,
0.07196211069822311,
0.007012247107923031,
0.009653874672949314,
-0.029876084998250008,
-0.011487552896142006,
0.010567938908934593,
0.005078552756458521,
0.007190207950770855,
0.0011537810787558556,
-0.017077602446079254,
0.024550244212150574,
-0.01356364507228136,
0.019754964858293533,
0.010684107430279255,
-0.006684501655399799,
0.0019290228374302387,
-0.005360481329262257,
0.009141110815107822,
0.02297360636293888,
-0.010642447508871555,
-0.002948231063783169,
-0.006693699397146702,
0.008729071356356144,
0.012794884853065014,
-0.0035484046675264835,
-0.012775443494319916,
-0.0271536223590374,
0.010550342500209808,
-0.03793913871049881,
0.013579655438661575,
0.012832734733819962,
-0.0019055175362154841,
0.0003698535729199648,
0.025872081518173218,
0.0050424570217728615,
0.008830363862216473,
-0.0041069574654102325,
0.012235780246555805,
-0.010242494754493237,
-0.002825047355145216,
-0.010118040256202221,
-0.0011521783890202641,
0.003092988394200802,
0.009530550800263882,
-0.009742636233568192,
0.0015924385515972972,
-0.015262048691511154,
0.02959558553993702,
-0.0030773435719311237,
0.0012855303939431906,
0.0040621403604745865,
0.0032951664179563522,
0.03114458918571472,
0.009466001763939857,
0.011423284187912941,
0.04377325624227524,
-0.03618747740983963,
-0.0028902236372232437,
-0.027269048616290092,
-0.012149853631854057,
0.03709370642900467,
-0.013645969331264496,
-0.010524665005505085,
-0.01990082859992981,
0.0008605553302913904,
0.004812733270227909,
0.010777449235320091,
-0.01851135864853859,
0.04435354471206665,
0.01498381607234478,
0.01669183187186718,
0.01749667152762413,
0.012649564072489738,
-0.003363503608852625,
0.004286096431314945,
0.04110966622829437,
0.011398529633879662,
-0.00675596809014678,
0.01343260146677494,
0.001407338073477149,
-0.011340231634676456,
-0.008161934092640877,
-0.015674427151679993,
0.0013262811116874218,
0.003804504871368408,
0.025542475283145905,
0.017486758530139923,
0.019652755931019783,
-0.004275492858141661,
0.00905967690050602,
0.01932288520038128,
-0.0010653575882315636,
0.011599105782806873,
0.003231264417991042,
0.013758438639342785,
0.0342598594725132,
0.020060084760189056,
0.0018879943527281284,
-0.010191760957241058,
0.013095945119857788,
0.0055085718631744385,
-0.01650620810687542,
-0.006548789329826832,
-0.0075333816930651665,
-0.03568604588508606,
0.00875595398247242,
0.010875675827264786,
-0.010509577579796314,
0.01111270859837532,
0.014842480421066284,
-0.007282985839992762,
-0.0018948278157040477,
0.008935995399951935,
0.016336102038621902,
0.00880283024162054,
0.018837518990039825,
-0.008668975904583931,
0.02597460336983204,
0.004280242137610912,
-0.017168719321489334,
-0.004017684608697891,
-0.022571153938770294,
-0.006344298832118511,
0.03491748869419098,
-0.017011243849992752,
-0.002461056225001812,
-0.011722544208168983,
0.011427847668528557,
-0.03633228316903114,
-0.013999398797750473,
0.018381278961896896,
-0.04519622027873993,
0.006888074334710836,
0.012837394140660763,
-0.03141777217388153,
-0.010915449820458889,
-0.01895192824304104,
0.0031476537697017193,
-0.01048625260591507,
-0.009570326656103134,
0.016416549682617188,
-0.013776374980807304,
0.005831100512295961,
0.0023020163644105196,
0.006621215492486954,
-0.012618828564882278,
0.017881717532873154,
0.0009193187579512596,
0.011202135123312473,
0.008629013784229755,
0.010576535016298294,
0.00562481302767992,
-0.01554238609969616,
-0.007812194526195526,
0.0016960392240434885,
0.009986450895667076,
0.0032350136898458004,
0.0024346662685275078,
0.019415993243455887,
-0.016704820096492767,
-0.017192814499139786,
-0.0050432803109288216,
-0.00003672949969768524,
-0.011625784449279308,
0.04011627286672592,
0.023635342717170715,
-0.008652093820273876,
-0.015313185751438141,
0.006259895861148834,
-0.006580687128007412,
0.0237285029143095,
0.009248321875929832,
-0.042838823050260544,
-0.000667839078232646,
0.0005417083157226443,
0.0025987697299569845,
-0.015920648351311684,
-0.01667090691626072,
0.007573082577437162,
-0.008876314386725426,
-0.0031998585909605026,
0.0313585102558136,
0.01869482919573784,
-0.005536491051316261,
-0.01752326823771,
0.002236182102933526,
-0.0033027357421815395,
0.009129284881055355,
0.01319080963730812,
-0.005262864753603935,
0.0035736938007175922,
-0.0003990801051259041,
0.017940113320946693,
0.02083107829093933,
0.015762751922011375,
-0.0064512440003454685,
0.02988414280116558,
0.05326540023088455,
0.011338159441947937,
0.001803761813789606,
0.009039012715220451,
-0.00007769931107759476
] | [
-0.2270900160074234,
-0.01231636293232441,
0.2624811828136444,
0.12479311227798462,
-0.004071204923093319,
-0.2731686234474182,
0.14307978749275208,
0.2718377113342285,
-0.4063277542591095,
-0.3067043125629425,
-0.19150696694850922,
0.18146684765815735,
-0.9991984963417053,
0.47101929783821106,
0.02154931053519249,
0.6282224655151367,
0.7739351391792297,
-0.1150197982788086,
-0.6543164849281311,
-0.6746540069580078,
-0.05455299839377403,
-0.5317831039428711,
0.7653364539146423,
0.13601525127887726,
0.1766432821750641,
-0.06332246959209442,
0.1529226303100586,
0.7118917107582092,
0.26255425810813904,
0.13580402731895447,
0.15358616411685944,
0.5412178039550781,
0.32617485523223877,
0.23754023015499115,
0.16039302945137024,
0.48731523752212524,
-0.3520996570587158,
-0.4270596206188202,
-0.03909282758831978,
-0.29338616132736206,
0.21097096800804138,
0.06178492680191994,
-0.4916819930076599,
0.6501408219337463,
-0.0852244570851326,
0.02020445466041565,
-1.3463767766952515,
0.6979174017906189,
-0.0423375628888607,
-0.20288453996181488,
0.13565203547477722,
0.5603797435760498,
0.3267154097557068,
0.06476908177137375,
0.4816921353340149,
-0.018825415521860123,
-0.624738335609436,
-0.13643907010555267,
0.30643776059150696,
-0.636766791343689,
-0.3426611125469208,
-0.18276865780353546,
-0.5947600603103638,
0.17774860560894012,
-0.28473344445228577,
0.39846909046173096,
0.06666529923677444,
0.05838381499052048,
-0.7795935273170471,
-0.31185248494148254,
0.10605136305093765,
-0.15228261053562164,
0.20210868120193481,
0.13043531775474548,
-0.3256310522556305,
0.08221521228551865,
-0.3723960816860199,
-0.7629840970039368,
0.34599995613098145,
-0.24896550178527832,
-0.22752486169338226,
-0.10494513809680939,
0.44744542241096497,
0.09487927705049515,
-0.06889627128839493,
0.20973539352416992,
-0.01627705991268158,
1.3163422346115112,
-0.01615912653505802,
0.4475943148136139,
-0.14887061715126038,
-0.28434813022613525,
0.5770127177238464,
0.32721754908561707,
0.15930067002773285,
0.08635180443525314,
0.3860777020454407,
-0.06641963869333267,
-0.0238201804459095,
0.15000785887241364,
0.16801434755325317,
0.11892110854387283,
-0.3645487129688263,
-0.22461993992328644,
-0.25562793016433716,
-0.14972443878650665,
-0.3581139147281647,
-0.5559377670288086,
-0.660139799118042,
0.22484341263771057,
-0.933323323726654,
-0.30446478724479675,
-0.6465078592300415,
-0.4666338562965393,
-0.2508457899093628,
0.10308746993541718,
0.07861800491809845,
-0.22904619574546814,
0.27320462465286255,
0.12256951630115509,
0.21129892766475677,
0.7864684462547302,
-0.6711793541908264,
0.29772645235061646,
0.12007225304841995,
-0.2299724817276001,
0.02171102911233902,
-0.0028714314103126526,
-0.043517716228961945,
0.7357126474380493,
0.00260361609980464,
0.4867952764034271,
-0.3311784565448761,
-0.2943115830421448,
0.571530282497406,
-0.3230925500392914,
0.20487992465496063,
-0.032745108008384705,
0.12099754810333252,
0.21776652336120605,
-0.30706754326820374,
-0.6625257730484009,
-0.37568092346191406,
-0.169211745262146,
0.10877376049757004,
-0.4751976728439331,
-0.1943981945514679,
0.051294270902872086,
0.33341267704963684,
-0.37381264567375183,
0.015016943216323853,
-0.06741128116846085,
-0.8744440078735352,
0.04386294260621071,
-0.21262648701667786,
0.2660275399684906,
-0.19485129415988922,
-0.38013914227485657,
-0.020029261708259583,
0.07096834480762482,
0.20868206024169922,
-0.18030284345149994,
-0.5437197089195251,
-0.15099208056926727,
0.20136094093322754,
0.06654560565948486,
0.3185959756374359,
0.1021948903799057,
0.007590738590806723,
-0.4969237446784973,
-0.6303564310073853,
-0.4273538887500763,
-0.0006423203158192337,
-0.732904851436615,
0.09924717992544174,
0.16180813312530518,
0.25757306814193726,
-0.05584586411714554,
0.5032562613487244,
-0.15873083472251892,
-0.8560280799865723,
-0.39764612913131714,
-0.040639158338308334,
-0.26153531670570374,
0.502882182598114,
0.1910269856452942,
0.6560693383216858,
-0.2646689713001251,
0.013781005516648293,
-0.2182784080505371,
-0.012151303701102734,
0.0038397307507693768,
1.1174850463867188,
-0.4072960913181305,
1.5579860210418701,
-0.13234950602054596,
0.0002857814833987504,
0.6641249060630798,
-0.015046610496938229,
-0.1278514266014099,
-0.1045464351773262,
0.41470956802368164,
0.30546197295188904,
-0.42332595586776733,
-0.49646660685539246,
-0.13688461482524872,
0.031424298882484436,
-0.05776817724108696,
-0.0536080002784729,
0.06287596374750137,
0.5351316332817078,
-0.7982720136642456,
-0.1614258736371994,
-0.12475673109292984,
0.6857331395149231,
-0.3361973464488983,
-0.33920979499816895,
0.009139439091086388,
-0.37853124737739563,
-0.2586616575717926,
0.35823574662208557,
-0.5644938349723816,
0.02215542271733284,
0.8851239085197449,
0.002911483636125922,
1.1084867715835571,
0.4026137590408325,
0.23711532354354858,
0.7194522619247437,
-0.31254106760025024,
0.33837318420410156,
-0.10868550091981888,
0.42654114961624146,
-0.20977553725242615,
-0.03168847784399986,
0.4127286970615387,
0.038767531514167786,
-0.40720170736312866,
0.16181686520576477,
-0.32316672801971436,
-0.14327965676784515,
0.3038354516029358,
-0.7120646238327026,
-0.019603826105594635,
-0.0847725048661232,
-0.4343256950378418,
-0.7597781419754028,
-0.026914015412330627,
-0.9922362565994263,
0.006624428555369377,
0.21520228683948517,
0.3961031138896942,
0.14829544723033905,
-0.22256088256835938,
0.05811813473701477,
0.17460834980010986,
-0.015777114778757095,
-0.4196510314941406,
-0.25158172845840454,
-0.46256139874458313,
-0.40487921237945557,
-0.06011637672781944,
-0.21462607383728027,
0.12875068187713623,
-0.7375304102897644,
-0.12479708343744278,
-0.15989847481250763,
0.21506305038928986,
0.8250654339790344,
0.3135400414466858,
0.20863361656665802,
-0.11759542673826218,
-0.639147162437439,
0.1143907755613327,
-0.06573831290006638,
-0.4667792022228241,
0.054867763072252274,
0.753371000289917,
-0.5197146534919739,
0.0484793446958065,
-0.37983304262161255,
0.6471596956253052,
0.7309020161628723,
-0.09857332706451416,
-0.5205462574958801,
0.24333596229553223,
-0.20361973345279694,
-0.3856322765350342,
-0.41219407320022583,
-0.1794363409280777,
-0.6434981226921082,
0.4426012933254242,
-0.5319041609764099,
0.1913292109966278,
0.0034231836907565594,
-0.3347344696521759,
-0.02199012227356434,
0.24158546328544617,
0.3611319661140442,
0.0012925028568133712,
-0.27224233746528625,
0.4609373211860657,
-0.18566541373729706,
-0.14880278706550598,
-0.05997857078909874,
0.07033990323543549,
-0.44774919748306274,
0.45342499017715454,
-5.6743574142456055,
0.09567231684923172,
0.02899160049855709,
-0.47101885080337524,
-0.15347641706466675,
-0.19698172807693481,
0.6585357189178467,
0.07567065954208374,
0.07586779445409775,
0.18489296734333038,
0.2966862916946411,
0.3699815571308136,
0.023549597710371017,
-0.31106486916542053,
-0.2665043771266937,
0.20592112839221954,
-0.36943259835243225,
-0.4183714687824249,
0.4679113030433655,
0.14745445549488068,
0.8477764129638672,
-0.1042700707912445,
-0.047930892556905746,
0.617753803730011,
-0.08985193818807602,
0.3590932786464691,
-0.7053201794624329,
0.18142971396446228,
-0.453917533159256,
-0.28999751806259155,
0.37227603793144226,
-0.5493807792663574,
-0.27166756987571716,
-0.26891157031059265,
0.24551047384738922,
-0.1424710601568222,
0.018393155187368393,
0.09681572020053864,
-0.337075799703598,
-0.18704348802566528,
0.332931250333786,
0.10851075500249863,
-0.12630300223827362,
0.058527763932943344,
0.8144600987434387,
-0.08444204926490784,
0.07105471938848495,
0.2989625632762909,
-0.6828398108482361,
0.8108922839164734,
0.4910188913345337,
-0.324148565530777,
-0.04891150817275047,
0.6230242252349854,
0.7694560289382935,
0.05555350333452225,
-0.05126213654875755,
0.1562124788761139,
-0.32141050696372986,
0.45603448152542114,
-0.18608827888965607,
0.39435115456581116,
-0.4152701497077942,
-0.3898645043373108,
-0.2764838635921478,
0.2652841806411743,
-0.62604820728302,
-0.0772993266582489,
0.7049872875213623,
-0.21063166856765747,
-0.04062104970216751,
0.2506665587425232,
0.5570773482322693,
-0.6481501460075378,
0.6330304145812988,
0.011779464781284332,
0.24648399651050568,
-0.007429127115756273,
0.3940720856189728,
-0.05270129814743996,
-0.4275290369987488,
-0.30188485980033875,
-0.02095917984843254,
-0.8297005295753479,
0.17858803272247314,
-0.9302822947502136,
-0.4191719889640808,
0.3628677725791931,
-0.026095585897564888,
0.20838811993598938,
0.3680868148803711,
-0.24277903139591217,
0.4794600307941437,
0.27695122361183167,
0.40631482005119324,
0.479552686214447,
0.4823623597621918,
0.9423946738243103,
0.6062581539154053,
-0.00028107388061471283,
0.6197971105575562,
-0.435513436794281,
0.12229632586240768,
-0.8998465538024902,
-0.044129855930805206,
0.030195802450180054,
-0.2169724553823471,
-0.026220623403787613,
0.731423556804657,
-0.7304898500442505,
0.4843529462814331,
0.04396595060825348,
-0.3349742889404297,
-0.3808290660381317,
0.6618568897247314,
-0.7875831723213196,
-0.20831310749053955,
0.45771053433418274,
0.4793699085712433,
-0.6522728800773621,
0.009701905772089958,
0.47663676738739014,
-0.5084762573242188,
0.32325538992881775,
-0.23926925659179688,
0.5572488903999329,
0.04229380190372467,
1.1474882364273071,
-0.6676924228668213,
-0.4514743387699127,
0.08130942285060883,
0.4568144381046295,
-0.05370829999446869,
-0.269885390996933,
0.01743832416832447,
-0.45581570267677307,
-0.8197357058525085,
0.4956599771976471,
0.1630638986825943,
-0.14226272702217102,
0.5465289354324341,
0.077894426882267,
0.008173900656402111,
-0.40567702054977417,
0.10396881401538849,
-0.07431293278932571,
-0.21044489741325378,
0.28000932931900024,
0.003249651752412319,
-0.16318392753601074,
0.45932337641716003,
0.11193160712718964,
0.23086294531822205,
-0.17495101690292358,
-0.16088378429412842,
0.7169130444526672,
0.4597893953323364,
0.1298614889383316,
0.2801109850406647,
-0.5823084115982056,
0.2510804831981659,
0.08018931746482849,
-1.3302057981491089,
-0.02155284211039543,
-0.17357884347438812,
0.4737682640552521,
-0.0336475595831871,
-0.6047092080116272,
0.38718339800834656,
0.5166798830032349,
-0.16311579942703247,
-0.35772451758384705,
-0.4631248116493225,
-0.06455980986356735,
0.19698172807693481,
-0.18809980154037476,
-0.5429255962371826,
-0.41803503036499023,
0.1937381774187088,
0.6919063329696655,
-0.03653307631611824,
-0.5671554207801819,
0.3438122272491455,
0.3743555247783661,
0.3984485864639282,
0.04164832457900047,
-0.05671471729874611,
-0.08519840240478516,
-0.015331120230257511,
-0.524813175201416,
0.39588630199432373,
-0.14931707084178925,
0.20693622529506683,
-0.2654864192008972,
0.09826589375734329,
-0.12320726364850998,
-0.21899913251399994,
0.806365430355072,
0.017356041818857193,
-0.6392021775245667,
-0.2986927628517151,
0.6447053551673889,
-0.14414606988430023,
0.14414966106414795,
1.0996159315109253,
-0.21216201782226562,
0.2200460135936737,
-0.030614495277404785,
-0.22696702182292938,
-0.1800278276205063,
-0.28397107124328613,
-0.33615586161613464,
0.3547944724559784,
0.29272714257240295,
-0.23555658757686615,
-0.031540028750896454,
0.06239037215709686,
-0.5143004655838013,
-0.6332345604896545,
0.3931010365486145,
0.1692095249891281,
0.09761594980955124,
0.21287290751934052,
-0.07519318908452988,
-0.5516740679740906,
0.2945712208747864,
0.4331341087818146,
-0.6502829194068909,
0.42282259464263916,
0.03548300638794899,
-0.19169485569000244,
-0.05708462372422218,
0.06729679554700851,
-0.18473970890045166,
-0.18243716657161713,
-0.3641844391822815,
0.14724858105182648,
0.3599178194999695,
0.4962480068206787,
0.28046607971191406,
0.3592481017112732,
0.4016813635826111,
-0.5686131715774536,
0.26331207156181335,
0.1774483174085617,
0.3460272550582886,
0.32369861006736755,
-0.6294785737991333,
-0.20861075818538666,
0.06186758726835251,
0.19915519654750824,
0.27305367588996887,
0.19742785394191742,
0.2866821885108948,
0.7889835238456726,
-0.1273190826177597,
-0.24322248995304108,
-0.7556214332580566,
-0.12004538625478745,
0.13944296538829803,
-0.5503721237182617,
0.41347378492355347,
0.22008340060710907,
0.056419260799884796,
0.1525057852268219,
0.007501731626689434,
-0.11053914576768875,
-0.6028043031692505,
0.4400864541530609,
-0.18384210765361786,
0.4400811195373535,
0.18515856564044952,
0.6664305329322815,
0.45776620507240295,
-0.3841690719127655,
0.4040808081626892,
-0.5526619553565979,
-0.45060667395591736,
-0.06255072355270386,
0.6678775548934937,
-0.12962111830711365,
-0.582668662071228,
0.02569146268069744,
-0.44019341468811035,
0.6391575336456299,
-0.8958946466445923,
0.39925262331962585,
-0.2369617223739624,
0.054208435118198395,
-0.4780767261981964,
-0.28269094228744507,
0.06814791262149811,
-0.2998129427433014,
-0.5076109170913696,
-0.2565992474555969,
-0.029383620247244835,
0.0709436908364296,
-0.058164238929748535,
-0.051506295800209045,
0.11117170006036758,
-0.427694708108902,
0.4046057164669037,
-0.020042473450303078,
-0.7890479564666748,
0.12655752897262573,
0.0799577534198761,
-0.05745096132159233,
-0.14131739735603333,
-0.5006590485572815,
-0.414279043674469,
-0.14021989703178406,
-0.17349480092525482,
0.19018159806728363,
0.4022899866104126,
-0.3923587203025818,
0.23549099266529083,
-0.2251627892255783,
-0.08403655141592026,
0.57474285364151,
0.12307929247617722,
0.41768017411231995,
1.3868554830551147,
0.5162301659584045,
-0.038522180169820786,
-0.21236133575439453,
0.12024244666099548,
0.005946825258433819,
0.10790126025676727,
0.34443148970603943,
0.8240699768066406,
0.41856247186660767,
-0.016124868765473366,
-0.4489074647426605,
1.1296944618225098,
0.3214631676673889,
-0.0938907116651535,
0.4501001238822937,
-0.35834452509880066,
-0.5617992281913757,
-0.3802528381347656,
0.7772172093391418,
-0.1624986082315445,
0.15945468842983246,
0.16411066055297852,
-0.08921284973621368,
0.38242340087890625,
0.40808480978012085,
0.32283374667167664,
-0.4704139232635498,
-0.08552447706460953,
0.5645173788070679,
-0.3784084916114807,
-0.1571979969739914,
-0.4286056160926819,
-0.5176641941070557,
0.3064095675945282,
0.2846587598323822,
-0.3339925706386566,
-0.6544442176818848,
0.012323535047471523,
-0.46668845415115356,
0.0712704136967659,
-0.2488931566476822,
0.747749388217926,
-0.028171580284833908,
0.09792984277009964,
0.30946865677833557,
0.2862245738506317,
0.5389584302902222,
0.11631616950035095,
-0.5862507224082947,
-0.09433527290821075,
-0.1494906097650528,
0.46657392382621765,
-0.04680662602186203,
-0.8008339405059814,
-0.4434194266796112,
0.4949515759944916,
0.3185752034187317,
0.2491191327571869,
-0.5984131693840027,
0.29589739441871643,
-0.3021324872970581,
-0.6058657169342041,
-0.04460261017084122,
-0.5075057744979858,
-0.15760579705238342,
-0.10029134154319763,
0.23127993941307068,
0.032089345157146454,
0.45846134424209595,
-0.32469695806503296,
-0.4943976104259491,
0.27524662017822266,
0.6567445993423462,
-0.36136552691459656,
0.1776990294456482,
0.18503233790397644,
-0.07141181826591492,
0.9384040832519531,
0.20164811611175537,
0.01144707202911377,
0.003371046157553792,
0.45749497413635254,
-1.020439624786377,
0.09032361954450607,
-0.029207153245806694,
0.13332639634609222,
-0.7475968599319458,
-0.1954452097415924,
0.6025513410568237,
0.8241032958030701,
-0.29485565423965454,
0.3341955542564392,
0.294980525970459,
0.4144786298274994,
0.2733790874481201,
-0.1951778531074524,
-0.20393601059913635,
-0.8332326412200928,
-0.2362949401140213,
-0.3476014733314514,
1.1053839921951294,
0.10642854124307632,
0.13240548968315125,
-0.14343972504138947,
0.5898115634918213,
0.08947065472602844,
-0.21469531953334808,
0.5539026856422424,
-0.4195028841495514,
0.37237897515296936,
-0.262044757604599,
0.10727190226316452,
-0.6563907861709595,
-0.12527863681316376,
0.17850185930728912,
-0.3048188388347626,
-0.5340897440910339,
-0.13135942816734314,
-0.036847393959760666,
-0.5194332599639893,
-0.036233533173799515,
-0.3071082532405853,
0.13897642493247986,
-0.11523984372615814,
0.15714019536972046,
-0.32786571979522705,
-0.39998239278793335,
0.13976123929023743,
0.3330574929714203,
-0.7849634289741516,
-0.06687407195568085,
0.10177680104970932,
0.3038051128387451,
0.08812685310840607,
-0.24784865975379944,
-0.15658274292945862,
-0.3721206784248352,
0.029345693066716194
] |
Objectives Corin, an atrial natriuretic peptide-converting enzyme, has been found to promote trophoblast invasion and spiral artery remodeling. Reduced maternal plasma atrial natriuretic peptide (ANP) levels and elevated corin levels have been reported in pregnancies complicated by PE. The aim of this study was to investigate longitudinal changes in maternal plasma levels of corin and midregional proatrial natriuretic peptide (MR-PANP) in pregnancies that develop preeclampsia (PE) and gestational hypertension (GH). Methods Nested case control study drawn from a larger prospective longitudinal study in singleton pregnancies identified by screening at 11 + 0 − 13 + 6 weeks’ gestation as being at high risk for PE. Blood samples were taken every four weeks until delivery. Values were compared in pregnancies that developed preterm-PE (requiring delivery before 37 weeks), term-PE, GH, and those that remained normotensive. The distribution of maternal plasma corin and PANP were made Gaussian after log 10 transformation. Analysis of repeated measures with multilevel mixed-effects linear model (fixed effects and random effects) was performed. The multilevel model was compared to one-level model by the likelihood radio (LR) test. Results A total of 471 samples were analyzed from 122 women, including 85 that remained normotensive, 12 that developed GH, 13 term-PE and 12 preterm-PE. In the normotensive group, log10corin levels were associated with gestational age ( p p = 0.001). In the GH and term-PE groups, corin did not differ significantly from the normotensive group ( p = 0.64 and p = 0.16, respectively). Compared to the normotensive group, MR-PANP levels were significantly higher in the pregnancies that developed preterm-PE and GH ( p = 0.046 and p = 0.019, respectively), but not term-PE ( p = 0.47). Conclusions Maternal plasma corin and MR-PANP could potentially be useful biomarkers for the prediction of preterm-PE. Disclosures A. Khalil: Research Support Recipient; Commercial Interests: USCOM, Roche, Alere, NICOM, Q-fFN; Speaker: Roche. | [
-0.011757412925362587,
0.012949206866323948,
-0.018365316092967987,
0.02205677516758442,
0.020595870912075043,
-0.016710422933101654,
0.0100766746327281,
0.001594136469066143,
-0.0070566581562161446,
-0.00625113770365715,
0.002354598604142666,
0.009077765047550201,
-0.01329604908823967,
0.011270999908447266,
0.01983489841222763,
0.0023011669982224703,
-0.008196615613996983,
0.001122145215049386,
0.008924419991672039,
-0.009685647673904896,
0.00933362077921629,
-0.013839896768331528,
0.008765166625380516,
0.0031119685154408216,
0.02416463941335678,
0.00842574518173933,
0.035389602184295654,
0.008619079366326332,
0.01267505157738924,
-0.029895994812250137,
0.018255217000842094,
-0.006700323894619942,
0.002269987016916275,
0.000682478304952383,
-0.004731649532914162,
0.0016014919383451343,
-0.006380687467753887,
0.02145538665354252,
0.016553308814764023,
-0.005600803531706333,
-0.007596193812787533,
-0.013151835650205612,
0.004658558405935764,
0.01919836550951004,
-0.004902726970613003,
-0.007230591028928757,
-0.0027713566087186337,
0.02248998172581196,
0.005007978994399309,
0.0020884135738015175,
0.0022110622376203537,
-0.030360553413629532,
-0.014323720708489418,
-0.005690489895641804,
-0.005013319198042154,
-0.004178828559815884,
0.014983942732214928,
-0.004990679211914539,
-0.02887643687427044,
-0.012515692040324211,
0.01459159143269062,
-0.0021137050352990627,
0.007445565424859524,
-0.016655009239912033,
-0.008675452321767807,
-0.06695900112390518,
0.008661871775984764,
-0.03227588161826134,
-0.002048204420134425,
-0.010318053886294365,
0.0045499796979129314,
0.009935648180544376,
0.004176846239715815,
-0.01536231953650713,
-0.03005497343838215,
-0.006637015379965305,
-0.009768735617399216,
-0.018527502194046974,
-0.01620037853717804,
-0.023430148139595985,
-0.013032685965299606,
-0.0013359934091567993,
-0.002122015692293644,
0.0022662938572466373,
-0.0006166235543787479,
-0.0008270144462585449,
-0.014231808483600616,
0.005860611330717802,
0.01288307923823595,
-0.006929013412445784,
0.00884923618286848,
0.024232126772403717,
-0.019288325682282448,
0.011786304414272308,
0.015384944155812263,
0.01349541824311018,
0.029111936688423157,
-0.012953365221619606,
0.040545754134655,
-0.0308147631585598,
-0.028674431145191193,
-0.019889820367097855,
0.014499481767416,
0.006761775352060795,
-0.03528511896729469,
0.005608642008155584,
0.024243712425231934,
0.019435709342360497,
0.0231887549161911,
0.007387835532426834,
-0.02320229262113571,
-0.00027913821395486593,
0.012870668433606625,
0.0007631446933373809,
-0.005308470688760281,
0.02078508585691452,
0.00007936730980873108,
-0.026392528787255287,
0.011579526588320732,
-0.002092407550662756,
0.008833855390548706,
0.010985272005200386,
0.0010117236524820328,
0.0016134902834892273,
-0.00041376863373443484,
-0.0039732856675982475,
0.01515127345919609,
-0.0023547655437141657,
-0.014143062755465508,
-0.0057782577350735664,
-0.00378113379701972,
0.00976947508752346,
-0.012791219167411327,
0.00036044325679540634,
-0.00393037311732769,
0.007934285327792168,
0.013227887451648712,
-0.012665879912674427,
-0.005562092177569866,
-0.005833873525261879,
0.009308184497058392,
0.009981557726860046,
0.0025047350209206343,
0.009505994617938995,
-0.008794651366770267,
-0.0015070266090333462,
-0.01631050370633602,
0.005603608675301075,
-0.018257150426506996,
-0.009462599642574787,
-0.0014850792940706015,
0.01613440178334713,
-0.021781228482723236,
-0.01659470424056053,
0.0159143153578043,
0.006101828068494797,
-0.0034734203945845366,
-0.0014574825763702393,
-0.006532164290547371,
0.00268600694835186,
-0.00971950963139534,
-0.009869599714875221,
0.012683059088885784,
0.007848653011023998,
-0.009607398882508278,
0.000517985608894378,
-0.005746099632233381,
-0.01811027154326439,
-0.019184008240699768,
0.00668935663998127,
-0.0051904055289924145,
0.010592576116323471,
0.012893946841359138,
0.0068456814624369144,
-0.009616060182452202,
-0.004568439908325672,
0.00346930674277246,
0.004756585229188204,
-0.012532273307442665,
0.06606259196996689,
-0.025205835700035095,
0.015851754695177078,
0.03144438564777374,
-0.00840613804757595,
0.0020793143194168806,
-0.014657750725746155,
-0.001134808175265789,
-0.0018739975057542324,
0.001978111220523715,
0.033786654472351074,
-0.009273052215576172,
-0.011730397120118141,
-0.013921009376645088,
0.009416255168616772,
0.027735739946365356,
0.003823185572400689,
0.007378661073744297,
0.00882759690284729,
-0.0263429693877697,
-0.00840016733855009,
0.007354908622801304,
-0.014517400413751602,
0.014489991590380669,
0.00791335292160511,
0.010919145308434963,
0.005031640641391277,
-0.009272962808609009,
0.00016774330288171768,
-0.008347352035343647,
0.00547331478446722,
0.03002377785742283,
-0.009937545284628868,
-0.008341170847415924,
-0.01328369602560997,
0.018211867660284042,
-0.0007521852385252714,
0.010747024789452553,
-0.00014275545254349709,
-0.001758309081196785,
-0.01198483258485794,
-0.0004762294120155275,
0.01163471955806017,
-0.026347171515226364,
-0.010168700478971004,
0.009656046517193317,
0.015555543825030327,
0.012786393985152245,
0.009872904978692532,
0.0172226931899786,
0.000014996621757745743,
-0.0024977284483611584,
-0.024752844125032425,
-0.012993368320167065,
0.009597131982445717,
-0.003847262356430292,
0.0018750233575701714,
0.011496703140437603,
0.008111419156193733,
0.01145431399345398,
-0.011915944516658783,
0.00251444848254323,
0.0015443022130057216,
0.012200345285236835,
-0.011476149782538414,
0.016174517571926117,
-0.050628662109375,
0.014159232378005981,
-0.007438767701387405,
0.005797497928142548,
-0.01924176886677742,
0.007591330446302891,
-0.007648129016160965,
-0.008091773837804794,
-0.02181186154484749,
-0.01186397485435009,
-0.004984444007277489,
0.0018588844686746597,
-0.01524362899363041,
0.026614999398589134,
-0.019862772896885872,
0.003517045173794031,
0.007883978076279163,
0.003456374630331993,
0.0012920235749334097,
-0.00398190738633275,
0.01013424713164568,
-0.0007840764592401683,
-0.021351858973503113,
0.02103809081017971,
0.023935919627547264,
0.007076659239828587,
-0.012825331650674343,
-0.010371329262852669,
-0.08174502104520798,
-0.005898395553231239,
-0.021603286266326904,
-0.0014311750419437885,
0.001722170738503337,
0.03021613322198391,
0.0009770338656380773,
-0.000023475848138332367,
-0.011288510635495186,
-0.020123880356550217,
0.005259799771010876,
0.021036803722381592,
-0.004879937041550875,
-0.008569224737584591,
0.002265708986669779,
0.00041597255039960146,
0.00021658730111084878,
0.005998876411467791,
-0.01349389087408781,
-0.024901460856199265,
-0.010437200777232647,
-0.008682547137141228,
-0.03224792331457138,
0.0003710442688316107,
-0.010020699352025986,
-0.0023273280821740627,
-0.03474250063300133,
-0.013141999952495098,
-0.0030364568810909986,
0.005844284780323505,
-0.010425743646919727,
-0.008472028188407421,
0.0018299007788300514,
0.008384110406041145,
-0.003042087657377124,
-0.0015646428801119328,
-0.0026226132176816463,
0.002204239834100008,
-0.014104924164712429,
0.024276897311210632,
-0.028088204562664032,
0.009473457932472229,
0.021509932354092598,
-0.006506144534796476,
0.005147057119756937,
-0.007343000266700983,
0.02862897515296936,
0.014706199988722801,
0.01663917675614357,
-0.012092215940356255,
0.017040736973285675,
-0.010919000953435898,
0.01952587254345417,
0.02577545866370201,
-0.008749308064579964,
-0.013525315560400486,
0.024373872205615044,
0.011431815102696419,
-0.006434792187064886,
-0.006341707892715931,
-0.02146785520017147,
0.034692056477069855,
-0.010853312909603119,
0.03474275395274162,
0.01513249147683382,
-0.0010218515526503325,
0.016107400879263878,
-0.021560853347182274,
-0.0035655354149639606,
0.020598294213414192,
0.00860703457146883,
-0.0015765714924782515,
-0.015535552054643631,
-0.004477852024137974,
0.007251698058098555,
-0.011206893250346184,
-0.016301777213811874,
0.0019341619918122888,
-0.01747668907046318,
-0.008115226402878761,
-0.006921140942722559,
-0.0017945545259863138,
0.012374280020594597,
0.005728402175009251,
-0.01880473643541336,
0.004825593437999487,
0.011294439435005188,
0.01180804893374443,
0.010461229830980301,
-0.016343537718057632,
0.004663704428821802,
0.03428260609507561,
-0.010274389758706093,
0.013602742925286293,
-0.012635845690965652,
-0.02243315428495407,
-0.004575012251734734,
0.013887187466025352,
0.026411453261971474,
0.007889784872531891,
-0.02460925653576851,
0.0034191543236374855,
-0.010814759880304337,
-0.0045745656825602055,
0.005938423331826925,
0.011853320524096489,
0.0019490441773086786,
0.01597873866558075,
-0.00483729038387537,
0.0027385910507291555,
-0.02331753633916378,
-0.0013126095291227102,
-0.0028664933051913977,
0.030849885195493698,
0.005740507505834103,
-0.0013195028295740485,
-0.009347429499030113,
0.009731152094900608,
0.07222893834114075,
0.012963605113327503,
-0.015977753326296806,
-0.005518445745110512,
0.01680431328713894,
-0.02164750173687935,
-0.01052258163690567,
0.002942431718111038,
0.013494940474629402,
0.0325789675116539,
0.013086563907563686,
-0.043416641652584076,
-0.00461475970223546,
0.01606046035885811,
-0.03713085502386093,
-0.0015013095689937472,
-0.0006277612410485744,
-0.024445943534374237,
0.0213234331458807,
0.005097620189189911,
-0.004540836438536644,
-0.02611193060874939,
0.0017491296166554093,
-0.005594878923147917,
0.008276659063994884,
0.00020202226005494595,
0.009379781782627106,
-0.01511230506002903,
-0.026937460526823997,
0.007351640146225691,
-0.003924819640815258,
-0.014722498133778572,
-0.00752375740557909,
-0.017227690666913986,
0.008875908330082893,
0.00619502691552043,
-0.009665857069194317,
0.01615888811647892,
-0.007084400858730078,
-0.018823489546775818,
0.02401087060570717,
-0.013642141595482826,
0.010803069919347763,
0.010197152383625507,
0.000658957869745791,
-0.006120241712778807,
-0.00393372867256403,
-0.010141996666789055,
-0.0033066438045352697,
-0.014488267712295055,
-0.019208479672670364,
-0.003913441207259893,
0.0056222593411803246,
0.022921478375792503,
-0.003237924538552761,
0.0016565201804041862,
0.01830507628619671,
-0.004581594839692116,
-0.009250061586499214,
-0.015315570868551731,
0.001090887701138854,
-0.001862912904471159,
0.00048513105139136314,
0.003305208869278431,
-0.02529141865670681,
-0.017971064895391464,
0.0028364232275635004,
-0.012084757909178734,
-0.004244913812726736,
-0.0008340829517692327,
-0.024943256750702858,
0.005538014695048332,
0.030883587896823883,
-0.004160475917160511,
-0.007746264338493347,
-0.008475442416965961,
-0.022087769582867622,
0.004978699143975973,
-0.006336289923638105,
-0.013581886887550354,
-0.0031382902525365353,
0.004746926948428154,
0.019873108714818954,
-0.0028116689063608646,
0.014457931742072105,
0.023723475635051727,
-0.013217822648584843,
-0.07579820603132248,
-0.0004090931615792215,
0.014750570058822632,
-0.005107684060931206,
-0.006314209662377834,
0.020490743219852448,
-0.013150030747056007,
-0.0015755703207105398,
-0.026814760640263557,
-0.004461257252842188,
0.03456834703683853,
0.0009092183317989111,
0.020885106176137924,
0.004356547724455595,
0.011161194182932377,
-0.001814655028283596,
-0.012517046183347702,
0.010671946220099926,
0.023177260532975197,
-0.009523794054985046,
-0.01179082877933979,
-0.00864857155829668,
-0.035686008632183075,
0.011999355629086494,
-0.01079759281128645,
-0.08101627230644226,
-0.009293081238865852,
0.01319426205009222,
0.0058063361793756485,
0.008407672867178917,
-0.02177794650197029,
0.017090562731027603,
-0.006065125577151775,
-0.0037245508283376694,
-0.01461403351277113,
-0.007004898972809315,
0.0001455536112189293,
-0.019772928208112717,
-0.01830962300300598,
0.0002931179478764534,
-0.006531312596052885,
0.008144757710397243,
0.009933901950716972,
-0.015392600558698177,
0.02026095613837242,
0.013227209448814392,
0.016041597351431847,
-0.008299202658236027,
-0.01619783602654934,
-0.005535962991416454,
-0.007454537786543369,
0.0034479573369026184,
0.014142819680273533,
-0.005455237813293934,
-0.02078751102089882,
-0.020252499729394913,
-0.025982696563005447,
-0.022067226469516754,
-0.00938111636787653,
-0.008466370403766632,
-0.010072004981338978,
-0.008374517783522606,
-0.019205212593078613,
-0.003615757916122675,
-0.02129371464252472,
0.0001980098895728588,
0.01238805241882801,
-0.0317714586853981,
0.0033851058688014746,
-0.012926474213600159,
-0.017137743532657623,
0.0042845578864216805,
-0.01160447858273983,
0.005492504686117172,
-0.011187359690666199,
0.009878558106720448,
0.0158227626234293,
0.009176593273878098,
0.0025367657653987408,
0.013630786910653114,
0.022091232240200043,
-0.004687870852649212,
0.004480476025491953,
0.009856561198830605,
0.006821115501224995,
-0.007720351684838533,
0.01614614576101303,
0.0014547155005857348,
0.07119949162006378,
-0.006310704629868269,
0.015208869241178036,
0.00004994124174118042,
-0.0016678519314154983,
0.005179794505238533,
0.014714435674250126,
-0.002813933650031686,
-0.005742018111050129,
-0.0009516867576166987,
0.0091102235019207,
-0.00709377508610487,
-0.008516291156411171,
0.017356928437948227,
0.0028074937872588634,
0.014368312433362007,
0.014400454238057137,
0.020840495824813843,
-0.0037211456801742315,
0.006503925658762455,
0.019891560077667236,
0.018987124785780907,
-0.011151039972901344,
-0.0009061736054718494,
0.01996627077460289,
0.0038723263423889875,
0.020735731348395348,
0.004341543186455965,
-0.021773403510451317,
0.0003435458056628704,
-0.005107785575091839,
-0.022794775664806366,
-0.0014219626318663359,
-0.006661527790129185,
0.008468751795589924,
0.025111468508839607,
0.015080118551850319,
0.007891204208135605,
0.01479342021048069,
-0.004108856897801161,
-0.0008592519443482161,
-0.010942843742668629,
0.005332418717443943,
-0.010097485035657883,
0.03626757115125656,
-0.009007936343550682,
0.010339067317545414,
0.04502388834953308,
0.00047009444097056985,
-0.004761870019137859,
-0.01476136315613985,
-0.0026979977265000343,
-0.04014423489570618,
-0.030056575313210487,
0.013656478375196457,
-0.02294711396098137,
-0.02698998898267746,
0.01086803711950779,
-0.0010833386331796646,
-0.003819788107648492,
0.001179255428723991,
-0.011748315766453743,
0.010594915598630905,
-0.018396973609924316,
0.026130249723792076,
-0.028623880818486214,
0.01608368381857872,
-0.006787250749766827,
-0.026256561279296875,
0.016748417168855667,
-0.008905460126698017,
0.018285684287548065,
0.00574996042996645,
0.02147684246301651,
0.03505558893084526,
0.014842947944998741,
0.011611100286245346,
0.000569893280044198,
0.030042432248592377,
0.008715342730283737,
-0.018012570217251778,
-0.009468195959925652,
0.0033280067145824432,
0.005539486184716225,
0.01470983773469925,
-0.00726353982463479,
0.016203422099351883,
-0.014103870838880539,
0.006335543468594551,
0.007025719620287418,
-0.01567467302083969,
0.006661566905677319,
0.008397839032113552,
0.025541044771671295,
0.005250424146652222,
0.0350511409342289,
0.022889316082000732,
-0.0011513464851304889,
-0.021409224718809128,
0.014026721008121967,
-0.0013903607614338398,
0.012370307929813862,
-0.0227708388119936,
0.00914003886282444,
0.009558679535984993,
-0.007903728634119034,
-0.010646450333297253,
0.004650705493986607,
0.03223196417093277,
-0.008981251157820225,
-0.006330220494419336,
-0.024179965257644653,
0.01820474863052368,
-0.0046803648583590984,
0.0013600647216662765,
0.026056338101625443,
-0.01143269706517458,
-0.007184482645243406,
0.0066712722182273865,
-0.010426465421915054,
-0.01484981644898653,
-0.014678150415420532,
-0.0006246757693588734,
0.010118714533746243,
0.012918859720230103,
-0.0253024622797966,
-0.014204496517777443,
0.007167528383433819,
0.015303639695048332,
-0.040035225450992584,
0.028865011408925056,
0.0026371993590146303,
0.021836670115590096,
0.014017843641340733,
-0.007543011102825403,
-0.020862219855189323,
-0.0008197420975193381,
-0.006689685396850109,
0.005606771446764469,
0.005152409430593252,
0.029209604486823082,
-0.0002996590919792652,
-0.0029827626422047615,
0.03385970741510391,
0.006247124634683132,
-0.01985897123813629,
-0.002357621444389224,
0.005055396817624569,
0.007280096411705017,
0.0336683988571167,
-0.010974837467074394,
0.009299051016569138,
0.005921873264014721,
-0.0077761271968483925,
0.014998105354607105,
0.015873217955231667,
0.005150088109076023,
-0.04226738214492798,
-0.010591006837785244,
-0.005890225060284138,
0.013371998444199562,
-0.007382101379334927,
0.01207603607326746,
0.012674901634454727,
0.009889795444905758,
-0.012638507410883904,
-0.024798773229122162,
-0.00782371498644352,
0.006976253353059292,
-0.008378666825592518,
-0.0022533051669597626,
0.005016619339585304,
0.002373120281845331,
0.015343702398240566,
-0.04104996472597122,
-0.014310753904283047,
-0.015586773864924908,
0.017655024304986,
0.02391716279089451,
0.025324661284685135,
-0.0036962167359888554,
-0.00043031235691159964,
0.026695096865296364,
-0.008313472382724285,
0.022779032588005066,
-0.000970522640272975,
-0.003104934236034751,
0.01587747409939766,
0.002391689456999302,
0.022784020751714706,
-0.016867049038410187,
0.013262299820780754,
-0.01445179246366024,
0.010208433493971825,
-0.03870987892150879,
0.0036428652238100767,
-0.03156174719333649,
-0.021247711032629013,
0.009341459721326828,
0.01289433054625988,
-0.009775148704648018,
0.005909367930144072
] | [
-0.02216407097876072,
0.05174979940056801,
0.35260146856307983,
0.13352341949939728,
0.3499431610107422,
0.2786940932273865,
-0.1895139217376709,
-0.21710853278636932,
-0.27332803606987,
-0.15551462769508362,
-0.0686177983880043,
0.7045199871063232,
0.024261895567178726,
-0.28142908215522766,
-0.013758106157183647,
0.6502339839935303,
0.7366047501564026,
0.31334441900253296,
-0.35369235277175903,
-0.5944490432739258,
-0.26561102271080017,
-0.3986627459526062,
0.601751983165741,
-0.24809613823890686,
-0.00979269202798605,
0.04833720251917839,
0.5672408938407898,
-0.10611008107662201,
0.08628282696008682,
-0.08388286083936691,
-0.13168969750404358,
0.610274076461792,
0.14897698163986206,
-0.08917009085416794,
-0.3579409420490265,
0.23763015866279602,
-0.10050100833177567,
-0.17123942077159882,
-0.18555304408073425,
-0.4666358530521393,
-0.10603874176740646,
-0.2531251609325409,
0.06684838235378265,
0.24417777359485626,
-0.2989530563354492,
-0.2975676655769348,
-1.6308562755584717,
0.3458765149116516,
-0.2528950870037079,
0.0004173420020379126,
0.18504995107650757,
0.4215262234210968,
-0.19036199152469635,
0.2028791308403015,
0.1328035145998001,
0.6909446716308594,
-0.5827609896659851,
-0.6013904809951782,
-0.14971429109573364,
-0.6378096342086792,
-0.41527092456817627,
0.12065229564905167,
-0.09143185615539551,
0.45087283849716187,
-0.18853972852230072,
0.17200224101543427,
0.09348364919424057,
-0.17745675146579742,
-0.2976439297199249,
-0.6242334842681885,
-0.005010442342609167,
-0.1690971553325653,
-0.45720911026000977,
0.2679802179336548,
-0.18202681839466095,
-0.12323088943958282,
-0.0064755333587527275,
-0.08115103095769882,
0.5848496556282043,
-0.14774833619594574,
0.33935919404029846,
-0.0903865322470665,
0.5099769234657288,
-0.23486623167991638,
-0.00692342035472393,
0.18586000800132751,
-0.037039365619421005,
0.47281214594841003,
-0.5250503420829773,
0.1390269547700882,
-0.07703067362308502,
-0.1697155386209488,
0.4673798084259033,
0.556984543800354,
0.3483431935310364,
0.036684077233076096,
0.13149219751358032,
-0.3724207580089569,
-0.06734480708837509,
-0.11727511882781982,
-0.34861740469932556,
0.03563550487160683,
-0.6132848262786865,
-0.39032140374183655,
-0.8152575492858887,
0.10650643706321716,
-0.2727898061275482,
-0.7145164608955383,
-0.9012790322303772,
0.1815972477197647,
-0.6667320132255554,
0.3930281698703766,
-0.10192665457725525,
0.20034092664718628,
-0.07973422110080719,
-0.17933222651481628,
0.15090347826480865,
-0.06411479413509369,
-0.2656484842300415,
0.21337313950061798,
0.4228955805301666,
1.4352312088012695,
-0.04688620567321777,
0.23059457540512085,
0.5312617421150208,
0.14068739116191864,
0.5502890944480896,
0.23157818615436554,
0.050064001232385635,
0.5718666911125183,
0.26043397188186646,
0.08101125061511993,
-0.28396502137184143,
-0.03441344574093819,
-0.010592385195195675,
-0.1730157881975174,
0.14953100681304932,
-0.09258394688367844,
0.4702615439891815,
0.3595467805862427,
-0.5246348977088928,
-0.6918895840644836,
0.08961918205022812,
-0.1640336662530899,
0.36225923895835876,
-0.39778658747673035,
0.22536884248256683,
0.41461285948753357,
-0.3612845242023468,
-0.1264546662569046,
0.7194226980209351,
-0.2556363344192505,
-0.28609055280685425,
-0.32472559809684753,
0.04161917790770531,
0.40141358971595764,
0.05499215051531792,
-0.20592071115970612,
-0.31979548931121826,
0.12713460624217987,
0.500391960144043,
0.21368308365345,
-0.7702763080596924,
-0.3588950037956238,
0.3118540942668915,
0.0005299023468978703,
0.19432789087295532,
0.388459712266922,
0.22328315675258636,
0.054844487458467484,
-0.018273651599884033,
-0.33311691880226135,
0.057195574045181274,
-0.6380200386047363,
-0.07243503630161285,
0.39447781443595886,
0.2893737852573395,
0.23300635814666748,
0.23949098587036133,
0.18833127617835999,
-0.8431079983711243,
0.23343674838542938,
-0.193551167845726,
-0.8293394446372986,
0.30491870641708374,
0.17656873166561127,
0.4597227871417999,
-0.25444507598876953,
0.032489195466041565,
0.3014543056488037,
-0.551910400390625,
-0.2544291317462921,
0.795781135559082,
-0.8525311946868896,
1.1981170177459717,
-0.21348534524440765,
-0.41597282886505127,
0.9643886685371399,
0.4146758019924164,
-0.10185772180557251,
-0.30591702461242676,
0.21420247852802277,
0.39423030614852905,
-0.25136327743530273,
-0.7715803980827332,
-0.19142870604991913,
-0.09225192666053772,
-0.16468535363674164,
-0.6546769738197327,
0.5971090793609619,
0.07432757318019867,
0.16956211626529694,
0.12497450411319733,
-0.14391645789146423,
0.6059439182281494,
-0.11234716325998306,
-0.15424548089504242,
0.38265761733055115,
-0.3947732150554657,
0.22093752026557922,
-0.16907335817813873,
-0.3759186863899231,
0.4109952747821808,
0.6741567850112915,
0.07697254419326782,
0.7739013433456421,
0.49702414870262146,
-0.07018981873989105,
0.5734749436378479,
-0.2572648525238037,
-0.06337635964155197,
0.09605932235717773,
0.45882731676101685,
-0.5178636312484741,
0.08825060725212097,
0.17121143639087677,
0.24231360852718353,
-0.19070319831371307,
0.2966853082180023,
0.06635023653507233,
-0.5616475343704224,
0.29461967945098877,
-0.5250486135482788,
0.5120860934257507,
-0.19037052989006042,
-0.010057945735752583,
-0.5962262749671936,
0.15128947794437408,
-0.7331099510192871,
-0.21381962299346924,
-0.19125792384147644,
0.3203427791595459,
0.02557806856930256,
0.09932535141706467,
0.23167917132377625,
-0.19093413650989532,
-0.050234876573085785,
-0.30738234519958496,
-0.058045580983161926,
-0.24261075258255005,
-0.09855623543262482,
0.2752571105957031,
0.1978428065776825,
0.40693578124046326,
0.2666107416152954,
-0.42992541193962097,
-0.602340579032898,
-0.09555841982364655,
0.621617317199707,
0.7819825410842896,
0.1473277509212494,
0.026518022641539574,
-0.7505353093147278,
0.10731417685747147,
0.20217059552669525,
-0.33560872077941895,
-0.14720579981803894,
0.8538306355476379,
-0.6000999212265015,
-0.9611929059028625,
-0.09535806626081467,
0.4016970098018646,
0.430006742477417,
0.08829671889543533,
-0.02420126274228096,
-0.1995524764060974,
-0.2794489562511444,
-0.49006620049476624,
-0.2526148557662964,
-0.48382067680358887,
-0.24576255679130554,
0.5291881561279297,
-0.1499342918395996,
-0.31181180477142334,
0.47441384196281433,
0.35819488763809204,
-0.2393701821565628,
0.7845933437347412,
0.4721299111843109,
-0.014442244544625282,
0.10891959071159363,
0.17640353739261627,
0.19687750935554504,
-0.443793386220932,
0.427465558052063,
0.07435020059347153,
0.01652008853852749,
0.1952907294034958,
-6.01528263092041,
0.007305532693862915,
-0.3746718466281891,
0.16473796963691711,
-0.30670061707496643,
-0.12872064113616943,
0.739602267742157,
-0.18678361177444458,
0.2594270408153534,
-0.11839908361434937,
0.4177359640598297,
0.1934768408536911,
-0.29023104906082153,
0.27014967799186707,
-0.015071343630552292,
0.43936794996261597,
0.3834340572357178,
-0.25181612372398376,
0.5299185514450073,
0.27356794476509094,
0.21673130989074707,
-0.22910162806510925,
0.07725092768669128,
0.8211880922317505,
0.518417477607727,
0.09651164710521698,
-0.719498872756958,
0.24655495584011078,
-0.016612710431218147,
-0.44827473163604736,
0.3807406425476074,
0.1641065627336502,
0.1502533257007599,
-0.054537564516067505,
0.5147448778152466,
0.14098939299583435,
0.11249978095293045,
-0.2314845472574234,
0.1779112070798874,
-0.46659016609191895,
0.11703386157751083,
0.3139658272266388,
-0.16380678117275238,
-0.09386030584573746,
-0.04954221844673157,
-0.4698723256587982,
0.11721719801425934,
0.4733622670173645,
-0.2605098783969879,
0.48810118436813354,
0.019319765269756317,
-0.1450435072183609,
-0.15050338208675385,
0.4820350408554077,
0.26048287749290466,
0.16868172585964203,
-0.09958358854055405,
0.062361449003219604,
-0.7481595277786255,
0.6474025249481201,
0.02919880300760269,
-0.07253547757863998,
-0.11522167921066284,
-0.7012664079666138,
0.1322431117296219,
0.26197341084480286,
-0.6751147508621216,
-0.5600740909576416,
0.0936007872223854,
-0.23548683524131775,
-0.22955191135406494,
0.2247890830039978,
-0.2560598850250244,
-0.7140328884124756,
-0.1762915700674057,
-0.43287283182144165,
0.18584947288036346,
0.19578570127487183,
0.17910149693489075,
-0.055321354418992996,
-0.15021051466464996,
-0.460639625787735,
0.18984119594097137,
-0.027106977999210358,
-0.012312710285186768,
0.3179265260696411,
-0.05590546876192093,
0.05060854181647301,
-0.21051205694675446,
0.4827852249145508,
0.18911390006542206,
-0.1592959761619568,
0.22671706974506378,
0.7002092599868774,
0.1354658156633377,
0.3007766306400299,
0.5193531513214111,
0.5579874515533447,
0.30540645122528076,
0.07876413315534592,
0.025394683703780174,
0.11518454551696777,
-0.35551562905311584,
-0.3796553909778595,
-0.23928824067115784,
0.12044142186641693,
-0.23154740035533905,
-0.45830145478248596,
0.6525236368179321,
-1.1031019687652588,
0.2176315039396286,
0.2062990665435791,
-0.2691611349582672,
-0.15040840208530426,
0.40740638971328735,
-0.12492768466472626,
0.3135479986667633,
0.2705972492694855,
0.7103734612464905,
-0.21572832763195038,
0.3333127498626709,
0.26407483220100403,
-0.5693633556365967,
0.06673538684844971,
-0.35278448462486267,
-0.2063870131969452,
-0.07914578914642334,
0.4572507441043854,
-0.5054796934127808,
0.3546895384788513,
0.479169636964798,
0.5038009881973267,
-0.47198042273521423,
-0.45226407051086426,
0.6454614996910095,
-0.3087083399295807,
-0.28844624757766724,
0.13435940444469452,
-0.05455358698964119,
-0.052959930151700974,
0.09213059395551682,
-0.15760783851146698,
-0.19222740828990936,
-0.012430627830326557,
0.13074615597724915,
-0.34971243143081665,
-0.03913038969039917,
-0.3824068307876587,
-0.15965187549591064,
0.25246304273605347,
0.14179882407188416,
-0.011453960090875626,
0.30734753608703613,
0.21246252954006195,
0.30334943532943726,
0.13460688292980194,
0.19968441128730774,
-0.3321153521537781,
0.2439623773097992,
-0.508530855178833,
0.5811284780502319,
0.2104819267988205,
-1.2128909826278687,
-0.3765549659729004,
-0.0002665822394192219,
-0.3760271966457367,
-0.19760122895240784,
-0.5430094599723816,
-0.2897336184978485,
0.46183380484580994,
0.5024956464767456,
-0.38574108481407166,
-0.2909243106842041,
-0.00741808395832777,
-0.38731589913368225,
-0.2767123878002167,
-0.245152086019516,
-0.4695203900337219,
-0.1038910299539566,
-0.305162250995636,
0.3033563196659088,
-0.5219472646713257,
0.08167518675327301,
-0.5272421836853027,
0.6054180860519409,
-0.025180021300911903,
-0.04255056753754616,
-0.13666139543056488,
-0.022158950567245483,
-0.27944207191467285,
-0.27952006459236145,
0.14424169063568115,
0.04046066850423813,
-0.11647295206785202,
-0.043720971792936325,
0.20158523321151733,
0.09619303047657013,
0.153311088681221,
-0.12769918143749237,
-0.08911468833684921,
-0.4859497845172882,
0.3555867075920105,
-0.23168157041072845,
0.295692503452301,
0.17016001045703888,
-0.23261718451976776,
-0.18395191431045532,
0.24103915691375732,
-0.37562358379364014,
0.013203568756580353,
-0.16972696781158447,
-0.534447431564331,
0.1501498520374298,
0.03485460579395294,
-0.07689516991376877,
0.1930435299873352,
0.19956156611442566,
-0.15436270833015442,
-0.9548366665840149,
0.3528634011745453,
0.34596458077430725,
-0.23426553606987,
-0.4102816581726074,
-0.15816150605678558,
-0.22935965657234192,
-0.33567801117897034,
0.7203492522239685,
-0.7967117428779602,
0.4090654253959656,
0.04644649848341942,
-0.5143103003501892,
-0.2231852114200592,
0.4949008524417877,
0.3267098367214203,
-0.030758153647184372,
-0.056647270917892456,
-0.45061856508255005,
0.35638684034347534,
0.1323145180940628,
-0.15135926008224487,
-0.3839241862297058,
0.22868812084197998,
-0.4863976240158081,
-0.03375735506415367,
0.061087507754564285,
0.8021003007888794,
-0.014548932202160358,
-0.3664874732494354,
-0.5691560506820679,
0.3091203272342682,
0.23814252018928528,
-0.041071608662605286,
0.13082019984722137,
0.20879176259040833,
0.3429311215877533,
-0.107913076877594,
-0.15087348222732544,
-0.3373219072818756,
-0.5207740068435669,
0.531608521938324,
-0.2520013153553009,
-0.11417859047651291,
-0.3623034358024597,
0.04597880691289902,
0.07090576738119125,
0.4212874174118042,
0.4508291482925415,
-0.6549128890037537,
-0.3653324842453003,
0.0032546198926866055,
0.4144144058227539,
0.04796220362186432,
0.579316258430481,
0.6805512309074402,
-0.059667445719242096,
-0.1532955765724182,
-0.044390641152858734,
-0.21457462012767792,
-0.03433240205049515,
-0.14383402466773987,
-0.19323040544986725,
-0.14850066602230072,
0.16246512532234192,
-0.44628632068634033,
0.17298659682273865,
-0.8812711834907532,
0.10655762255191803,
0.04772339388728142,
-0.2840041518211365,
-0.37013155221939087,
0.1739276796579361,
0.5513901710510254,
-0.9691211581230164,
-0.9292513132095337,
0.21323077380657196,
0.07353964447975159,
0.19151045382022858,
0.15025626122951508,
-0.03100942261517048,
0.08648500591516495,
-0.4043358564376831,
0.43146786093711853,
0.5943092703819275,
-0.433686226606369,
-0.09698465466499329,
0.4566608965396881,
0.047813646495342255,
-0.38637152314186096,
-0.5272748470306396,
0.14927811920642853,
-0.12116806954145432,
-0.13218006491661072,
0.3181181252002716,
-0.02117740735411644,
-0.5950862169265747,
0.24418140947818756,
-0.108228899538517,
-0.48389366269111633,
0.5236073136329651,
0.6202828884124756,
-0.050393544137477875,
0.4860723912715912,
0.802751362323761,
0.22050362825393677,
-0.10151448845863342,
-0.09945020079612732,
0.14576415717601776,
0.3746761977672577,
0.4150816798210144,
0.9753326177597046,
0.25850123167037964,
0.9917005300521851,
0.0176235418766737,
0.7303224205970764,
0.10994591563940048,
-0.17787081003189087,
-0.1727285385131836,
-0.7652572393417358,
-0.13089300692081451,
0.054645564407110214,
0.9066564440727234,
0.25238341093063354,
0.07232417166233063,
-0.3480619192123413,
-0.005504382774233818,
0.3222971558570862,
0.20671024918556213,
0.31957146525382996,
-0.4806808531284332,
0.18385371565818787,
0.33506500720977783,
-0.28223368525505066,
-0.6625072360038757,
0.021084047853946686,
-0.16919441521167755,
0.27782952785491943,
0.2105887085199356,
-0.02150808461010456,
-0.950951099395752,
0.12469624727964401,
-0.36639949679374695,
0.23245355486869812,
-0.017191488295793533,
0.41609957814216614,
-0.25202828645706177,
-0.3081522285938263,
0.1991027295589447,
0.608921229839325,
0.5851959586143494,
0.1262332797050476,
0.06195950508117676,
0.0739041194319725,
-0.19591902196407318,
0.34807273745536804,
0.09577162563800812,
-0.593460738658905,
0.03287772461771965,
-0.18628333508968353,
0.46028992533683777,
0.14493511617183685,
-0.4462094306945801,
0.286650687456131,
0.010823470540344715,
-0.31757745146751404,
-0.3663153052330017,
-0.22544850409030914,
-0.10128973424434662,
-0.00947868637740612,
0.05461319535970688,
-0.3756481111049652,
0.36032000184059143,
-0.24679841101169586,
0.007735864259302616,
0.3152792751789093,
-0.212864488363266,
0.27978888154029846,
-0.1671132594347,
0.15671689808368683,
0.17194028198719025,
0.7716078162193298,
-0.2532604932785034,
0.0606551356613636,
0.0816638395190239,
0.5616028904914856,
-0.1852761209011078,
0.030203618109226227,
-0.6885302066802979,
-0.15944619476795197,
-0.4978496730327606,
-0.5489060878753662,
0.46646779775619507,
0.5252162218093872,
-0.23017534613609314,
0.17983631789684296,
0.011513783596456051,
-0.13008172810077667,
0.39934319257736206,
0.1476851999759674,
0.19843368232250214,
0.032323844730854034,
-0.030572224408388138,
-0.3162344694137573,
0.5464709401130676,
-0.34423011541366577,
-0.3095383048057556,
0.25066766142845154,
0.29871413111686707,
0.36460909247398376,
0.1221076101064682,
0.03188410401344299,
-0.3519608676433563,
-0.24292707443237305,
-0.26392272114753723,
0.5859912037849426,
-0.911429762840271,
-0.026157252490520477,
0.13154371082782745,
-0.12068639695644379,
0.06203354522585869,
-0.2591973841190338,
-0.1517598032951355,
-0.4633353650569916,
0.3965044617652893,
-0.09300000965595245,
0.308771014213562,
0.2643015384674072,
0.13972434401512146,
-0.28295788168907166,
-0.6554788947105408,
0.2620272934436798,
-0.3973909914493561,
-0.2949706017971039,
-0.24995042383670807,
-0.27673542499542236,
-0.17302018404006958,
-0.06126857176423073,
0.35821467638015747,
-0.6051787734031677,
-0.23183086514472961,
0.08057929575443268
] |
The reorganized and newly revised "Children's Exercise Physiology, Second Edition, " presents the most up-to-date research, methodology, and approaches related to children's physiologic responses to exercise. The book examines not only the current major issues that separate children from adults, but also the underlying mechanisms of these differences. Readers will learn what makes children different from adults physiologically--such as size, biochemical differences, neuromuscular differences, and lack of sexual and hormonal maturation--and the reasons for these differences. Those involved with young athletes, disease management, and health promotion will gain valuable insight into the physiologic determinants of exercise performance. Children's exercise physiology is a fast-moving field. In the eight years since the first edition of this book was published, much new information has surfaced. This streamlined new edition contains 13 instead of 15 chapters, an introduction, and updated features: -Chapter objectives, discussion questions and research directions, and a glossary of terms promote learning.-A reorganized table of contents improves the flow from chapter to chapter.-A new final chapter covers the role of the central nervous system. Also included is in-depth discussion of the determinants of aerobic fitness and VO2 kinetics and the significance of maximal aerobic power in children. With improved chapters on thermoregulation and metabolic and endocrinologic responses to exercise, you can be confident you're getting the latest information with "Children's Exercise Physiology, Second Edition. " | [
-0.01754104346036911,
0.017846155911684036,
-0.018943268805742264,
0.0343698225915432,
0.021459639072418213,
-0.016892284154891968,
0.007924702018499374,
-0.0016780511941760778,
-0.013469652272760868,
-0.021810201928019524,
-0.00898189377039671,
0.012286634184420109,
-0.008951103314757347,
0.006826428230851889,
0.0068763382732868195,
0.03035736456513405,
-0.010672365315258503,
0.011175282299518585,
0.007404466159641743,
-0.021303348243236542,
-0.0037767610047012568,
0.00631773192435503,
0.007891757413744926,
-0.016389068216085434,
-0.03733603656291962,
0.007505013607442379,
-0.004416278563439846,
-0.006344269961118698,
0.02318001538515091,
0.01122956071048975,
0.010907002724707127,
-0.000023451517336070538,
0.002632254734635353,
0.005068309139460325,
0.011619318276643753,
0.0009108677040785551,
-0.005039665848016739,
0.026614191010594368,
0.02279059961438179,
-0.0027934429235756397,
-0.009825605899095535,
0.0015172581188380718,
0.013971442356705666,
-0.013594957068562508,
-0.006466384511440992,
0.008274399675428867,
-0.002434720518067479,
-0.00012500211596488953,
-0.026787638664245605,
0.010874468833208084,
-0.0027915879618376493,
0.012323692440986633,
-0.006666730158030987,
0.0010473462752997875,
-0.005599427968263626,
0.01453348994255066,
0.019753828644752502,
-0.013109857216477394,
-0.009809332899749279,
-0.03397751599550247,
0.0031719268299639225,
0.0041803279891610146,
-0.0356130413711071,
-0.011223405599594116,
0.0024295421317219734,
-0.06603790074586868,
-0.025672685354948044,
0.004643419291824102,
-0.014421029016375542,
-0.0006275123450905085,
-0.016396962106227875,
0.011821399442851543,
-0.017987100407481194,
-0.005895999725908041,
-0.02059708535671234,
0.0013909596018493176,
-0.0012229967396706343,
0.00687671871855855,
0.045836273580789566,
0.0024683577939867973,
-0.0003082629991695285,
-0.028130512684583664,
0.025786304846405983,
0.03241246938705444,
-0.004074401222169399,
0.015250473283231258,
-0.021704498678445816,
-0.00037860416341573,
-0.005920517258346081,
-0.034900084137916565,
0.0069077638909220695,
-0.005881199147552252,
-0.01891375705599785,
0.013896442949771881,
-0.03688869625329971,
0.03716236725449562,
0.007962105795741081,
-0.02562364563345909,
0.019886964932084084,
-0.024444807320833206,
-0.004133777227252722,
-0.010306859388947487,
0.017479373142123222,
-0.03527853637933731,
-0.012587900273501873,
0.017368927597999573,
0.01542640570551157,
0.012928072363138199,
-0.02114151604473591,
0.005670715589076281,
0.0067806122824549675,
0.012378821149468422,
-0.01988951861858368,
0.022681839764118195,
-0.020119046792387962,
0.016811445355415344,
0.0029784280341118574,
0.008723663166165352,
0.017397886142134666,
0.007659969385713339,
-0.002570154145359993,
-0.00847550481557846,
0.0068462081253528595,
0.010903793387115002,
0.0011103127617388964,
-0.0031041218899190426,
-0.023329924792051315,
-0.0006731401663273573,
-0.03342949599027634,
0.010544697754085064,
-0.007912232540547848,
0.005665772594511509,
0.03264591470360756,
0.037518445402383804,
-0.030402811244130135,
-0.022850342094898224,
-0.02085915021598339,
0.01034030131995678,
-0.015402658842504025,
-0.021969106048345566,
0.02898620069026947,
0.004490767605602741,
0.008152417838573456,
-0.006390483118593693,
0.025420259684324265,
-0.0053681195713579655,
0.015589657239615917,
0.018595628440380096,
-0.005917898379266262,
-0.031664103269577026,
0.020815538242459297,
-0.0028121331706643105,
-0.013163143768906593,
-0.02228735387325287,
-0.01599019579589367,
0.011141435243189335,
0.004425486084073782,
0.021173885092139244,
0.002251663710922003,
0.02484268695116043,
-0.029691066592931747,
0.015907417982816696,
0.027199571952223778,
0.006885467562824488,
0.00817599706351757,
0.011598896235227585,
0.020662080496549606,
-0.016399409621953964,
0.002726284321397543,
0.003472041105851531,
-0.01185985654592514,
0.016040673479437828,
-0.024570282548666,
0.0055550383403897285,
0.035246364772319794,
-0.0059495242312550545,
-0.0015439963899552822,
0.006374898366630077,
-0.0012350501492619514,
0.06562741100788116,
0.029491547495126724,
0.010403148829936981,
-0.011937206611037254,
0.029731588438153267,
-0.012628821656107903,
-0.014484763145446777,
0.028849616646766663,
-0.012436960823833942,
0.0019477137830108404,
-0.041167404502630234,
-0.0030981474556028843,
-0.009193533100187778,
0.000684008002281189,
0.0004467002581804991,
-0.00009188614785671234,
0.003837364027276635,
0.03592715784907341,
0.008717453107237816,
0.010719269514083862,
-0.015537085011601448,
-0.02372189611196518,
0.004381900187581778,
0.03564773499965668,
-0.01138942502439022,
-0.014693481847643852,
0.010422039777040482,
0.011785170063376427,
0.013132492080330849,
-0.005773072596639395,
0.014072254300117493,
-0.004184715449810028,
-0.018320173025131226,
-0.00797061063349247,
-0.0004397460725158453,
0.004300605971366167,
0.013656776398420334,
-0.02484341338276863,
0.00846801046282053,
0.004215531051158905,
-0.02315990813076496,
-0.0016048633260652423,
0.016612648963928223,
-0.012479778379201889,
-0.018095463514328003,
0.014011490158736706,
-0.00044289929792284966,
0.006497844122350216,
0.010642435401678085,
0.01882917433977127,
0.013388299383223057,
-0.018038293346762657,
0.01740717701613903,
-0.0036103606689721346,
-0.009062227793037891,
-0.02446671761572361,
-0.0002516563981771469,
0.0072539555840194225,
-0.01771439239382744,
0.008321555331349373,
-0.008148868568241596,
-0.024393752217292786,
-0.03502075374126434,
0.009107799269258976,
-0.011186009272933006,
0.026767928153276443,
0.016393277794122696,
-0.016119705513119698,
-0.0018824366852641106,
0.03688467666506767,
0.0043282234109938145,
0.0026933751069009304,
0.01849391870200634,
0.012954067438840866,
-0.030661432072520256,
0.010738975368440151,
-0.00469079427421093,
-0.05136067420244217,
0.0011644973419606686,
0.02486417256295681,
0.0011821500957012177,
0.0028206543065607548,
0.008256261236965656,
-0.005662331823259592,
-0.0008059288375079632,
0.0017739052418619394,
0.0014891535975039005,
0.0044547319412231445,
0.027155954390764236,
0.011233879253268242,
0.0002373687457293272,
0.004494065418839455,
-0.012860361486673355,
-0.010706435889005661,
-0.08081523329019547,
-0.00845322199165821,
-0.007568789646029472,
-0.021953560411930084,
0.012730197049677372,
-0.007448285818099976,
0.0015280417865142226,
-0.008953249081969261,
-0.017306575551629066,
0.008379627019166946,
-0.01667819172143936,
-0.013958357274532318,
-0.006783605553209782,
0.0406716987490654,
-0.03791338950395584,
-0.011299161240458488,
0.009898141957819462,
-0.012133277952671051,
-0.01709441840648651,
0.0009965936187654734,
0.010821010917425156,
-0.013693312183022499,
0.004773184657096863,
0.007092698942869902,
0.00011437805369496346,
-0.047308191657066345,
0.01807887852191925,
-0.010731926187872887,
-0.004010970238596201,
0.020463531836867332,
0.007378199603408575,
0.004021065309643745,
0.00018654263112694025,
-0.012953722849488258,
-0.012377222999930382,
0.01646517589688301,
-0.021206511184573174,
0.016946207731962204,
-0.029662244021892548,
-0.0015299331862479448,
-0.027352001518011093,
0.015050802379846573,
-0.0003863368183374405,
-0.010987412184476852,
-0.003178918734192848,
0.0068103354424238205,
0.02388780191540718,
-0.02662663348019123,
0.01220560260117054,
-0.008559373207390308,
0.0035592636559158564,
-0.0065869553945958614,
0.0010228871833533049,
0.003264294471591711,
-0.006575518287718296,
-0.012444475665688515,
-0.012893816456198692,
0.039346370846033096,
-0.012583236210048199,
-0.005903866142034531,
-0.01939232274889946,
-0.010596045292913914,
0.012066309340298176,
0.0019207177683711052,
-0.00303688645362854,
-0.022612810134887695,
0.007418716326355934,
0.0010175532661378384,
0.007553817704319954,
0.00889047235250473,
0.019457997754216194,
-0.01471819169819355,
-0.01984315738081932,
-0.005444109905511141,
-0.018471045419573784,
-0.01717657595872879,
-0.01706433854997158,
0.0004566045245155692,
0.007222428917884827,
0.005279087461531162,
-0.024476969614624977,
-0.0017313235439360142,
0.0015550167299807072,
-0.0036342404782772064,
-0.016044732183218002,
-0.021279791370034218,
-0.0004141202662140131,
0.013093836605548859,
0.017368033528327942,
-0.01504459697753191,
0.01633068546652794,
0.008073784410953522,
0.015533555299043655,
0.00732632540166378,
0.005228711292147636,
-0.014550331979990005,
0.03122785873711109,
-0.022105511277914047,
0.010044213384389877,
0.009631616994738579,
-0.02293536812067032,
0.01252724789083004,
0.010690415278077126,
-0.0046446011401712894,
-0.04239978268742561,
0.01899753138422966,
-0.011160321533679962,
-0.006268633529543877,
-0.022057678550481796,
-0.005099030211567879,
-0.011182129383087158,
0.009161368943750858,
-0.00044047506526112556,
0.008616776205599308,
0.007065771147608757,
-0.00007136387284845114,
-0.018523918464779854,
0.029924672096967697,
0.07154344022274017,
-0.017537469044327736,
0.02113308571279049,
0.009209871292114258,
0.01983622834086418,
-0.04702749848365784,
0.038040291517972946,
0.004892307333648205,
0.022909944877028465,
0.01154087483882904,
0.012055815197527409,
0.02130342274904251,
-0.021050378680229187,
0.041175954043865204,
-0.007753796875476837,
-0.011974819004535675,
-0.001947738230228424,
0.011806088499724865,
-0.004748097155243158,
-0.01129848975688219,
-0.004983740393072367,
-0.021986640989780426,
0.003915516193956137,
-0.011324477382004261,
0.004312159493565559,
-0.03979741036891937,
0.01764455810189247,
-0.010587584227323532,
0.017660580575466156,
0.0043958318419754505,
-0.02572052553296089,
0.02534240484237671,
-0.0009999640751630068,
0.0005533457733690739,
0.008653149008750916,
-0.015400409698486328,
0.01445751078426838,
-0.05892576277256012,
0.005860049277544022,
-0.01350359246134758,
-0.04987405985593796,
-0.016327522695064545,
0.006595058366656303,
0.012141568586230278,
-0.02696528472006321,
0.0011653667315840721,
-0.006513398140668869,
-0.0021247698459774256,
-0.0036180964671075344,
0.007845373824238777,
-0.0065710945054888725,
0.0003801342099905014,
0.009409070946276188,
-0.010473198257386684,
0.02268797531723976,
-0.01800616830587387,
-0.027333339676260948,
-0.0010432368144392967,
-0.01118649635463953,
0.031028959900140762,
-0.020337272435426712,
-0.016276836395263672,
0.02682921476662159,
-0.022152595221996307,
-0.012160246260464191,
-0.00856014247983694,
0.007457485888153315,
-0.013356717303395271,
0.013077321462333202,
-0.008954862132668495,
-0.012542381882667542,
-0.006393097341060638,
-0.0119084557518363,
0.015348890796303749,
0.01386401429772377,
-0.0555400513112545,
0.001850327244028449,
-0.009344554506242275,
-0.02020663395524025,
0.01606609672307968,
0.00006763450801372528,
-0.021204760298132896,
0.002134873066097498,
-0.013974899426102638,
0.02597564458847046,
-0.0018412030767649412,
-0.007687021512538195,
-0.07435224950313568,
-0.002899033948779106,
0.02489353157579899,
-0.010135605931282043,
-0.02278238907456398,
0.02268042042851448,
-0.01355014182627201,
-0.0025933226570487022,
-0.03337102010846138,
0.0009347535669803619,
-0.04137300327420235,
-0.003545025596395135,
-0.023821040987968445,
0.00587364099919796,
0.011434318497776985,
0.002516928594559431,
0.031309857964515686,
-0.009843757376074791,
-0.003947222605347633,
-0.02600140869617462,
-0.00033363141119480133,
-0.0005008566658943892,
0.014469856396317482,
0.007793528959155083,
-0.00601500179618597,
-0.08028478920459747,
-0.01740584708750248,
0.01017808262258768,
-0.005794021300971508,
-0.008019610308110714,
-0.013390382751822472,
0.023468703031539917,
-0.016814103350043297,
-0.00448343763127923,
-0.018306419253349304,
-0.01596132665872574,
-0.006591177545487881,
-0.018458519130945206,
-0.009497467428445816,
0.012978678569197655,
-0.009162217378616333,
-0.0017624428728595376,
-0.018871665000915527,
0.009995470754802227,
-0.015857718884944916,
-0.02651449665427208,
0.001548174535855651,
-0.009504638612270355,
0.012302467599511147,
-0.007835320197045803,
-0.033629972487688065,
-0.007008371874690056,
0.014942582696676254,
0.003782279323786497,
-0.015003380365669727,
-0.0033543116878718138,
0.026651067659258842,
-0.002366832224652171,
-0.02849821373820305,
0.000633785966783762,
-0.013057991862297058,
0.010743141174316406,
-0.021309619769454002,
0.0160830095410347,
-0.028014589101076126,
0.003921897150576115,
-0.0011510169133543968,
0.022865958511829376,
0.00896486733108759,
-0.018952567130327225,
-0.03319776803255081,
0.005736487917602062,
-0.0025789865758270025,
-0.003395544830709696,
-0.003836433170363307,
0.020887169986963272,
0.004040453117340803,
-0.011310593225061893,
0.015567468479275703,
0.020366167649626732,
0.026934705674648285,
-0.002829114207997918,
0.004550561308860779,
-0.017286941409111023,
-0.0007325669284909964,
0.0022556877229362726,
-0.0030848998576402664,
-0.013475243002176285,
0.07053806632757187,
0.0025749376509338617,
-0.014071471989154816,
-0.007528010755777359,
0.0006671522278338671,
0.00034047229564748704,
0.04275263100862503,
0.010704373940825462,
-0.0014553293585777283,
-0.01735229603946209,
-0.014875374734401703,
-0.01847228594124317,
-0.026282474398612976,
0.01112370379269123,
0.015615970827639103,
-0.004120835568755865,
0.010043677873909473,
0.013496335595846176,
-0.020991655066609383,
0.018429292365908623,
0.030977297574281693,
0.00853849295526743,
-0.007335154805332422,
0.01013471931219101,
0.014491409994661808,
-0.0054191527888178825,
0.013902567327022552,
0.0024320827797055244,
0.007230699528008699,
-0.020716562867164612,
-0.02095608040690422,
-0.03239157795906067,
0.00010048557305708528,
0.021969683468341827,
0.020662376657128334,
-0.003122274298220873,
-0.009019296616315842,
-0.006893620826303959,
-0.011265458539128304,
0.014402895234525204,
0.03365427628159523,
0.0007535247132182121,
0.0029706195928156376,
-0.005285181105136871,
0.013109392486512661,
0.02020995505154133,
0.03886130452156067,
-0.00734365452080965,
0.012279459275305271,
-0.0041101654060184956,
-0.00020804349333047867,
0.001956422347575426,
0.002260936889797449,
-0.0009628371335566044,
-0.010493583977222443,
0.01856658235192299,
-0.015727723017334938,
0.029052814468741417,
0.00491329887881875,
0.008789177983999252,
0.019984830170869827,
-0.015907209366559982,
0.02674628421664238,
-0.014719955623149872,
-0.026540705934166908,
-0.005770167801529169,
-0.013836011290550232,
-0.00991152785718441,
-0.007483635097742081,
0.021851196885108948,
-0.038388900458812714,
0.009743413887917995,
0.004815505351871252,
0.001760417828336358,
0.004146383609622717,
-0.0011588505003601313,
-0.005239879712462425,
-0.003706440795212984,
0.00562485633417964,
-0.018041616305708885,
-0.015265652909874916,
-0.01669808104634285,
0.013794254511594772,
-0.035066697746515274,
-0.00876641646027565,
-0.032600175589323044,
0.025239786133170128,
0.000018109101802110672,
-0.0026525226421654224,
0.0020589225459843874,
0.026173079386353493,
0.006903450004756451,
0.007240618113428354,
0.01652137190103531,
0.00540216825902462,
0.03474634140729904,
0.016565442085266113,
0.004313713405281305,
-0.018064774572849274,
-0.023383846506476402,
-0.011507461778819561,
-0.005167541094124317,
0.013156430795788765,
-0.0005939060356467962,
0.0031907043885439634,
-0.00023738015443086624,
0.00915845762938261,
-0.023958522826433182,
-0.0016912948340177536,
-0.010690364055335522,
-0.022381938993930817,
0.0016951938159763813,
-0.013205474242568016,
0.01421390101313591,
0.004419451113790274,
-0.018215855583548546,
-0.009195227175951004,
-0.026816952973604202,
-0.005746173672378063,
-0.011609268374741077,
0.017565857619047165,
0.007890407927334309,
0.022764375433325768,
-0.015567542053759098,
-0.03418842703104019,
-0.011423183605074883,
-0.008840740658342838,
0.015096478164196014,
0.017323091626167297,
-0.0020360038615763187,
0.0010956658516079187,
-0.009115844033658504,
-0.019642096012830734,
-0.002866467460989952,
0.011262321844696999,
-0.0014363043010234833,
-0.027920205146074295,
0.013833142817020416,
-0.025774570181965828,
-0.009328758344054222,
0.014847636222839355,
0.0041294097900390625,
0.0016589302103966475,
0.011725002899765968,
0.007000805344432592,
0.019488919526338577,
0.01148348581045866,
0.006094010546803474,
0.0073355925269424915,
0.015618833713233471,
0.014127363450825214,
-0.009727341122925282,
-0.0031603937968611717,
-0.010239356197416782,
-0.018593456596136093,
0.019583411514759064,
-0.0045755705796182156,
0.006003615912050009,
0.010931207798421383,
-0.0038896650075912476,
-0.004504128359258175,
-0.01316200103610754,
0.018551655113697052,
0.01730385050177574,
-0.004259321838617325,
-0.009824112057685852,
0.01638749986886978,
0.00823911465704441,
-0.012187466025352478,
0.0008045085705816746,
0.031372033059597015,
-0.01330619491636753,
-0.01618611440062523,
0.016674436628818512,
-0.007443480659276247,
-0.02281285636126995,
-0.015687786042690277,
0.049770522862672806,
0.03042367845773697,
0.00631817989051342,
0.027493322268128395,
0.02125406637787819,
0.007662374526262283,
-0.011400396004319191,
-0.015807345509529114,
-0.0028672381304204464,
-0.011202343739569187,
0.012946270406246185,
0.00844599399715662,
-0.0072508216835558414,
-0.011628626845777035,
-0.0034986953251063824,
-0.016188524663448334,
0.015735402703285217,
-0.021167870610952377,
-0.025437291711568832,
-0.02527768909931183,
0.02455872669816017,
0.0008551930077373981,
0.0028228212613612413,
-0.006530054844915867,
0.0005691475234925747
] | [
0.2110518366098404,
-0.15657737851142883,
-0.22672857344150543,
0.21018868684768677,
0.31062257289886475,
0.2837992310523987,
0.16760344803333282,
-0.45119863748550415,
0.016081305220723152,
-0.7322269082069397,
-0.26510360836982727,
0.3844783306121826,
0.0683378204703331,
-0.10249489545822144,
-0.2871609032154083,
0.12915487587451935,
0.6289780735969543,
0.1506243199110031,
0.055529460310935974,
-0.1745166927576065,
-0.5685484409332275,
-0.09680051356554031,
0.7574176788330078,
0.07024739682674408,
0.09462076425552368,
0.08614900708198547,
0.7398766875267029,
0.2541758418083191,
-0.22955553233623505,
-0.23053714632987976,
-0.6013768315315247,
0.20671913027763367,
-0.30376020073890686,
0.035829197615385056,
-0.2590271830558777,
0.17283278703689575,
-0.15877412259578705,
-0.4174020290374756,
0.22295525670051575,
-0.1968899518251419,
0.13059309124946594,
0.44172754883766174,
-0.3977534770965576,
0.31097957491874695,
0.22937516868114471,
-0.38925960659980774,
-1.5625495910644531,
-0.32092857360839844,
-0.4404252767562866,
0.1195211187005043,
-0.3029178977012634,
0.06868996471166611,
0.3680633008480072,
0.12418650090694427,
-0.22690947353839874,
0.19200707972049713,
-0.4106310307979584,
0.20247620344161987,
0.00986944418400526,
-0.26830095052719116,
0.2399005889892578,
0.6042852401733398,
-0.17525246739387512,
0.44628652930259705,
-0.07206333428621292,
-0.13474074006080627,
0.23499898612499237,
0.06750724464654922,
-0.12565594911575317,
-0.3599536418914795,
-0.2339141070842743,
-0.1618553102016449,
-0.47688716650009155,
0.5246497988700867,
0.26260796189308167,
0.05199095979332924,
0.08942302316427231,
0.007498706690967083,
0.40767696499824524,
-0.41879239678382874,
0.1199454814195633,
0.437969833612442,
0.37147486209869385,
-0.2673666477203369,
0.23105505108833313,
0.034736912697553635,
0.19345737993717194,
0.3973017632961273,
-0.23191392421722412,
0.30597925186157227,
-0.11934398114681244,
-0.40545615553855896,
0.4086490273475647,
0.3181615173816681,
0.7496936321258545,
-0.11511827260255814,
0.17511768639087677,
-0.4838702976703644,
-0.04133618250489235,
-0.07590389996767044,
-0.33040714263916016,
0.07885865122079849,
0.21469314396381378,
0.19760842621326447,
-0.45791077613830566,
-0.5694205164909363,
0.2449570894241333,
-0.8480954170227051,
0.13963519036769867,
0.5706281661987305,
-0.3290847837924957,
0.23710206151008606,
-0.006529453210532665,
-0.353471964597702,
0.022450875490903854,
0.045938294380903244,
0.1291973739862442,
-0.028785966336727142,
-0.9595605134963989,
0.263973593711853,
-0.1872006356716156,
0.2877815365791321,
0.31037595868110657,
-0.07572884857654572,
0.3148362338542938,
0.21700631082057953,
0.22705578804016113,
0.29115161299705505,
-0.21311728656291962,
0.34852686524391174,
0.296874076128006,
-0.13230234384536743,
-0.22480173408985138,
-0.13504964113235474,
-0.19009704887866974,
-0.23383761942386627,
0.14950385689735413,
-0.16056235134601593,
0.0502290315926075,
0.8512281179428101,
0.20255756378173828,
-0.1818419247865677,
0.002430810360237956,
-0.3843347132205963,
-0.22999855875968933,
-0.5324416160583496,
0.003531235968694091,
0.18370701372623444,
-0.10113105177879333,
-0.07833214849233627,
0.5774152874946594,
0.06689973920583725,
-0.47690245509147644,
-0.09285388141870499,
-0.16760624945163727,
0.31019091606140137,
-0.0941086858510971,
0.07473976910114288,
0.0368952676653862,
0.0472678504884243,
0.03623305633664131,
-0.31008240580558777,
-0.49905094504356384,
0.05602815002202988,
-0.4060092866420746,
-0.17350222170352936,
0.8355202078819275,
0.4745405614376068,
0.3900740146636963,
-0.2746240496635437,
-0.08304286003112793,
-0.3354226052761078,
0.2980023920536041,
0.026596426963806152,
-0.2919049859046936,
0.19498662650585175,
0.6420416235923767,
0.5235856175422668,
0.11362545937299728,
0.0979672372341156,
-0.4125553071498871,
-0.21714961528778076,
-0.1489284783601761,
-0.07872195541858673,
0.7147669792175293,
-0.23423610627651215,
0.5158361792564392,
-0.2569110095500946,
-0.04461125284433365,
0.22968019545078278,
-0.06427065283060074,
-0.3355785608291626,
0.6612831950187683,
-0.3018922805786133,
0.8617265224456787,
-0.022921215742826462,
-0.38770219683647156,
1.094927430152893,
-0.5239023566246033,
0.2141946256160736,
0.19038715958595276,
-0.021110789850354195,
0.12439654767513275,
0.33401474356651306,
-0.4913940131664276,
-0.1704820841550827,
-0.07391320914030075,
-0.2994954586029053,
-0.3457788825035095,
0.07116235792636871,
0.21396644413471222,
0.05830224230885506,
-0.09712455421686172,
-0.18914218246936798,
0.008228791877627373,
0.025157688185572624,
0.46643292903900146,
0.5870353579521179,
-0.4535001814365387,
-0.000979370204731822,
0.5548863410949707,
-0.14399144053459167,
0.3824700713157654,
0.0024717459455132484,
0.09186249226331711,
0.5126790404319763,
0.6503767371177673,
0.49569034576416016,
0.26736587285995483,
-0.5608422756195068,
-0.07099076360464096,
0.10702498257160187,
0.6777989864349365,
-0.18537569046020508,
0.12411205470561981,
-0.07348862290382385,
-0.13308586180210114,
-0.7592860460281372,
0.14135894179344177,
-0.4953598380088806,
0.16765736043453217,
0.3828742206096649,
0.1911647915840149,
0.5013505220413208,
0.5423713326454163,
-0.046569813042879105,
-0.16732920706272125,
1.0302793979644775,
-0.7296997308731079,
-0.5427910685539246,
-0.051380857825279236,
0.29001250863075256,
0.3596799075603485,
0.3178582787513733,
-0.2255653738975525,
0.20045402646064758,
-0.5999903082847595,
-0.472734659910202,
0.7384240031242371,
0.17766612768173218,
0.20341819524765015,
-0.18418312072753906,
0.25235864520072937,
-0.06490516662597656,
-0.19916602969169617,
-0.4134400486946106,
-0.5933648943901062,
-0.7081940770149231,
0.20326536893844604,
0.13786450028419495,
0.23664753139019012,
0.5496307015419006,
-0.740868866443634,
0.25344792008399963,
-0.07138098031282425,
-0.3784761130809784,
0.5075482130050659,
0.032075826078653336,
-0.24095028638839722,
-0.3888492286205292,
-0.054890166968107224,
0.6788018345832825,
0.5564051866531372,
0.32388484477996826,
-0.5532318353652954,
-0.43671298027038574,
0.4156186282634735,
-1.0027207136154175,
-0.16757632791996002,
0.39282917976379395,
0.20748324692249298,
0.6574981212615967,
-0.30609554052352905,
-0.6830968260765076,
0.41305801272392273,
0.26550817489624023,
-0.2280777543783188,
0.2529985308647156,
0.19259551167488098,
0.11583024263381958,
0.41740870475769043,
-0.07970520853996277,
0.2986581027507782,
-0.029902612790465355,
0.14839015901088715,
-0.48843804001808167,
-0.07505480945110321,
0.017369085922837257,
-6.114345073699951,
-0.3209807872772217,
-0.588310718536377,
0.1994948536157608,
-0.34729328751564026,
-0.22494636476039886,
0.4646303355693817,
-0.14379417896270752,
-0.11365591734647751,
0.18585583567619324,
0.2143675684928894,
0.13603031635284424,
0.4677741229534149,
0.4334681034088135,
0.006496422924101353,
0.18001708388328552,
0.3697369396686554,
-0.01945396140217781,
-0.224736750125885,
0.06130709499120712,
0.6174200177192688,
-0.5201419591903687,
-0.13248753547668457,
0.661856472492218,
0.493669718503952,
0.3478790521621704,
-0.3989231586456299,
0.1014496311545372,
-0.33026623725891113,
-0.16771432757377625,
-0.03157883137464523,
-0.6445953845977783,
0.013914168812334538,
-0.21669454872608185,
0.7237262725830078,
0.40880852937698364,
0.002467487007379532,
0.42923325300216675,
0.5494307279586792,
-0.4151057004928589,
0.15177221596240997,
0.007937457412481308,
0.13510635495185852,
-0.3422670364379883,
-0.10241712629795074,
0.36700132489204407,
-0.37288424372673035,
0.21065674722194672,
-0.732761025428772,
0.9443038702011108,
0.03332216665148735,
0.30723825097084045,
0.02511189691722393,
0.10437824577093124,
-0.04209158942103386,
-0.2880980372428894,
-0.12329420447349548,
-0.18986351788043976,
-0.19235947728157043,
0.05576770007610321,
0.07050439715385437,
-0.31705141067504883,
-0.3671564757823944,
-0.4068627953529358,
-0.24559913575649261,
-0.19179928302764893,
-0.9046409726142883,
-0.5759292244911194,
0.03961979225277901,
0.647440493106842,
-0.8481327295303345,
0.11226166039705276,
0.4054441452026367,
-0.6116151213645935,
0.13110151886940002,
0.12196661531925201,
-0.14733847975730896,
0.23611468076705933,
-0.2537503242492676,
-0.22096306085586548,
-0.6232483983039856,
-0.5488351583480835,
-0.21602247655391693,
0.6527338624000549,
0.40016692876815796,
-0.24573928117752075,
-0.33070510625839233,
-0.16416440904140472,
-0.47862038016319275,
0.1322426199913025,
1.120278000831604,
-0.31068313121795654,
-0.3121049404144287,
0.13567626476287842,
0.5031247735023499,
0.08005785942077637,
-0.05375722050666809,
0.10341620445251465,
0.2927921414375305,
-0.5357749462127686,
0.12742844223976135,
-0.017501110211014748,
0.3380797207355499,
-0.21626222133636475,
0.05466078594326973,
-0.07481524348258972,
-0.413827508687973,
-0.2686496376991272,
0.6615369319915771,
-0.8042075037956238,
-0.2114047110080719,
-0.39577847719192505,
-0.4540168344974518,
-0.2639428973197937,
0.5521502494812012,
-0.18106423318386078,
-0.190054252743721,
0.09860178083181381,
0.13441091775894165,
0.15636342763900757,
0.057016871869564056,
-0.2360084503889084,
-0.05537969991564751,
-0.31169232726097107,
-0.94624924659729,
-0.3518192172050476,
0.15887226164340973,
0.264883428812027,
-0.19983364641666412,
0.11354412138462067,
0.6906169056892395,
0.17588968575000763,
-0.24229052662849426,
0.16661059856414795,
-0.02707567997276783,
-0.1722247451543808,
-0.2926607131958008,
0.14171965420246124,
-0.5439673662185669,
-0.1542409062385559,
0.08494025468826294,
0.17658929526805878,
0.5197899341583252,
-0.6616195440292358,
0.35833561420440674,
-0.10191457718610764,
0.05144713446497917,
-0.246975377202034,
-0.39627963304519653,
0.025664187967777252,
0.6671806573867798,
-0.2765860855579376,
0.11949306726455688,
0.08359813690185547,
-0.47062355279922485,
0.15678124129772186,
0.27767014503479004,
0.27035611867904663,
0.10223861783742905,
-0.16917625069618225,
0.2539653182029724,
-0.3609197437763214,
-0.9365612268447876,
-0.2149301916360855,
0.5702413320541382,
0.7693650722503662,
-0.3940298855304718,
-0.6463028192520142,
-0.01750893145799637,
0.17788951098918915,
0.5246415734291077,
-0.5110841989517212,
-0.19673043489456177,
-0.356726735830307,
-0.1301899552345276,
-0.05453813076019287,
0.09421650320291519,
-0.14096981287002563,
-0.17120890319347382,
0.07466214895248413,
0.07250840961933136,
-1.1687980890274048,
-0.03551911562681198,
0.2853030562400818,
0.4817081391811371,
0.059768807142972946,
0.04924718290567398,
-0.2933284342288971,
-0.2775110900402069,
-0.4092126786708832,
0.49247634410858154,
0.184973806142807,
0.4952547550201416,
-0.2777002453804016,
-0.3381973206996918,
-0.28978103399276733,
0.4871183931827545,
0.1226547434926033,
-0.06288745999336243,
-0.12083758413791656,
-0.3108886182308197,
0.12775073945522308,
0.03998184949159622,
0.5337082147598267,
0.45281580090522766,
-0.5210711359977722,
-0.3147130012512207,
0.000617381592746824,
-0.14541463553905487,
0.24426119029521942,
-0.2633626163005829,
-0.6767072081565857,
0.10603728145360947,
-0.0510077103972435,
-0.045049238950014114,
0.2645447254180908,
-0.34222906827926636,
-0.32191067934036255,
-0.40164411067962646,
0.21333961188793182,
0.13602761924266815,
-0.20018228888511658,
-0.6441905498504639,
-0.2051803469657898,
0.010949579998850822,
-0.3809492886066437,
0.46373507380485535,
-0.6278781890869141,
0.09027037024497986,
-0.19473755359649658,
-0.22476918995380402,
0.26417243480682373,
0.3463912606239319,
0.0946158617734909,
-0.4227624833583832,
-0.22392486035823822,
-0.825584352016449,
0.5341305136680603,
0.4545305371284485,
0.1939377337694168,
0.020007047802209854,
0.16262362897396088,
-0.32066264748573303,
0.12807077169418335,
-0.058913227170705795,
0.584835946559906,
0.012497642077505589,
-0.5802788734436035,
-0.2799386978149414,
0.35845479369163513,
-0.012144554406404495,
-0.0992923304438591,
0.1561717391014099,
-0.0039668516255915165,
0.6928373575210571,
-0.22977159917354584,
-0.20442622900009155,
-0.22933094203472137,
-0.2696165144443512,
0.05265958607196808,
0.140936940908432,
-0.13871918618679047,
-0.4263240694999695,
-0.14970338344573975,
0.20140814781188965,
0.23673664033412933,
0.22337664663791656,
-0.9063960313796997,
0.377553254365921,
-0.17517271637916565,
0.11353225260972977,
-0.09965291619300842,
-0.1855003386735916,
0.48747482895851135,
0.2861623466014862,
0.06595058739185333,
-0.24503695964813232,
-0.07722776383161545,
-0.07903691381216049,
0.13588081300258636,
0.1234406903386116,
0.04503179341554642,
0.09268911927938461,
-0.2491382211446762,
-0.032919637858867645,
-0.031575754284858704,
0.3251416087150574,
0.032281309366226196,
0.08796863257884979,
0.1690266877412796,
-0.3613753914833069,
-0.12295117229223251,
-0.44082242250442505,
-0.7929372787475586,
-0.2746070921421051,
0.3236851990222931,
0.3898499608039856,
-0.22685964405536652,
-0.35730794072151184,
-0.5086661577224731,
0.15030182898044586,
0.6881660223007202,
0.44807904958724976,
-0.36107999086380005,
-0.418693870306015,
0.4866377115249634,
0.24088387191295624,
0.004820483271032572,
-0.6454062461853027,
0.35986974835395813,
0.19559597969055176,
-0.21879562735557556,
0.5214788317680359,
0.7380265593528748,
-0.4146537482738495,
0.4658055007457733,
-0.22199766337871552,
0.01809992454946041,
-0.032061610370874405,
0.44379228353500366,
-0.06009327620267868,
0.3951875567436218,
0.4370913505554199,
-0.3672417402267456,
-0.8075681328773499,
0.30578529834747314,
-0.10000656545162201,
-0.12996472418308258,
0.09498365968465805,
0.32640349864959717,
0.4312511384487152,
0.7215263843536377,
-0.15845555067062378,
0.7765055298805237,
0.5139036774635315,
-0.363139808177948,
0.47927436232566833,
-0.12832151353359222,
-0.14828284084796906,
0.17038634419441223,
0.9316307306289673,
0.4078367352485657,
-0.023544088006019592,
0.08085935562849045,
-0.0988716408610344,
-0.30739909410476685,
0.04335499554872513,
0.011576955206692219,
-0.26835140585899353,
-0.020096182823181152,
0.14804863929748535,
-0.18587584793567657,
-0.15820515155792236,
-0.0073213521391153336,
0.15439701080322266,
-0.2528700828552246,
0.4362218677997589,
-0.8292282223701477,
-0.08473226428031921,
0.17357231676578522,
-0.2614883482456207,
0.4860103130340576,
-0.2888266146183014,
-0.3665366470813751,
0.20519152283668518,
0.15683992207050323,
0.8893618583679199,
0.21372917294502258,
-0.16754019260406494,
0.1340644657611847,
-0.4247419834136963,
0.1447596400976181,
-0.2842218279838562,
-0.49195241928100586,
0.054036546498537064,
-0.14409027993679047,
0.3744741976261139,
-0.38339632749557495,
0.40567314624786377,
0.6393281817436218,
0.41412416100502014,
0.10535292327404022,
-0.4013751447200775,
-0.554386556148529,
0.3736276924610138,
0.239495187997818,
0.3390747904777527,
0.10612165182828903,
-0.21426129341125488,
0.10824371129274368,
0.20773790776729584,
-0.7285021543502808,
-0.2201465666294098,
0.22682826220989227,
0.0037920386530458927,
-0.1653572916984558,
-0.14619986712932587,
0.7090860605239868,
0.20045946538448334,
0.18816430866718292,
0.13348834216594696,
-0.0034715887159109116,
-0.18914368748664856,
0.27749016880989075,
-0.6549884080886841,
0.07345312088727951,
-0.43170931935310364,
-0.13126225769519806,
-0.4179218113422394,
-0.1914251744747162,
0.6119112372398376,
0.18421752750873566,
-0.1068592220544815,
-0.4251708686351776,
0.16926059126853943,
0.6336652040481567,
-0.05644528195261955,
-0.42893287539482117,
-0.08601129055023193,
0.1706327646970749,
0.0042602322064340115,
-0.054797179996967316,
0.19323848187923431,
0.30939626693725586,
-0.37181979417800903,
-0.48139047622680664,
0.072516068816185,
-0.04685448110103607,
-0.5043919682502747,
-0.07292959094047546,
-0.26486173272132874,
-0.5306875109672546,
-0.20603114366531372,
0.44942089915275574,
-0.5882319808006287,
-0.2640331983566284,
0.2519857585430145,
0.1874116063117981,
0.2588452100753784,
-0.3054795563220978,
-0.32363009452819824,
0.048818960785865784,
0.5137436985969543,
1.0803600549697876,
0.09855560958385468,
0.07735943794250488,
-0.3255155384540558,
0.09382039308547974,
0.019728297367691994,
0.16656777262687683,
-0.21568742394447327,
0.8108551502227783,
-0.34895163774490356,
-0.2565326988697052,
0.040449827909469604,
-0.3697284162044525,
-0.09398829936981201,
-0.20070305466651917,
0.33653101325035095,
0.0015497453277930617
] |
1. Cost-Effectiveness Analysis as a Guide to Resource Allocation in Health: Roles and Limitations 2. Theoretical Foundations of Cost-Effectiveness Analysis 3. Framing and Designing the Cost-Effectiveness Analysis 4. Identifying and Valuing Outcomes 5. Assessing the Effectiveness of Health Interventions 6. Estimating Costs in Cost-Effectiveness Analysis 7. Time Preference 8. Reflecting Uncertainty in Cost-Effectiveness Analysis 9. Reporting Cost-Effectiveness Studies and Results Appendix A: Summary of Recommendations for the Reference Case Appendix B: Cost-Effectiveness of Strategies to Prevent Neural Tube Defects Appendix C: The Cost-Effectiveness of Dietary and Pharmacologic Therapy for Cholesterol Reduction in Adults | [
0.0182635635137558,
0.01652209274470806,
-0.014621897600591183,
0.023382145911455154,
-0.00010077981278300285,
-0.01942562870681286,
0.00838514231145382,
-0.012255861423909664,
-0.011888290755450726,
-0.0017161229625344276,
-0.0040589263662695885,
0.012586703523993492,
-0.020772110670804977,
0.02544524520635605,
-0.0186421237885952,
0.023795675486326218,
-0.001104637049138546,
0.021115217357873917,
0.009732751175761223,
-0.011464519426226616,
-0.019331511110067368,
0.023929959163069725,
0.0077927024103701115,
-0.002477087080478668,
-0.022320834919810295,
-0.013852757401764393,
-0.016700563952326775,
-0.009884722530841827,
0.014305168762803078,
-0.024573884904384613,
0.010293489322066307,
-0.0027339309453964233,
0.029262252151966095,
0.0034764278680086136,
0.031132666394114494,
-0.01688593439757824,
-0.0036659068427979946,
0.000782550428994,
-0.00526165496557951,
-0.002136216266080737,
0.014343824237585068,
-0.0037680964451283216,
0.007863173261284828,
0.0002386891283094883,
-0.009956283494830132,
-0.0022026184014976025,
-0.002785224001854658,
0.0001187941525131464,
-0.009136248379945755,
0.011370792984962463,
-0.016151342540979385,
-0.017603687942028046,
0.0004796055145561695,
-0.02370433136820793,
-0.004395371302962303,
-0.012663310393691063,
0.019953258335590363,
-0.0076316469348967075,
-0.021613236516714096,
0.018315114080905914,
0.01895616203546524,
0.009617311879992485,
-0.0034908242523670197,
-0.004926830995827913,
0.020957637578248978,
-0.06684587895870209,
0.008691065944731236,
0.03424326702952385,
-0.001471363939344883,
-0.0012332301121205091,
0.007701538037508726,
0.018218176439404488,
-0.009130875580012798,
-0.013373615220189095,
0.0017246990464627743,
0.012669838964939117,
-0.006854237522929907,
0.007189305033534765,
0.028098801150918007,
0.008836203254759312,
0.0066866143606603146,
-0.000280904583632946,
-0.02570224553346634,
0.02171502634882927,
0.005948793143033981,
-0.001055174507200718,
-0.009808222763240337,
-0.017551949247717857,
0.01736084185540676,
0.008799374103546143,
-0.03274310380220413,
-0.0236140638589859,
0.00017698761075735092,
0.010999244637787342,
0.0030435281805694103,
-0.004589668475091457,
-0.021490130573511124,
-0.0040527828969061375,
0.0060229008086025715,
-0.01267012394964695,
-0.02872888371348381,
0.008753810077905655,
0.018413692712783813,
-0.0011593373492360115,
0.004446288105100393,
0.0027030864730477333,
-0.04320196062326431,
0.019209735095500946,
-0.010105771012604237,
0.0033141272142529488,
-0.0036313843447715044,
0.018018903210759163,
0.02218751236796379,
-0.00518563250079751,
0.020115649327635765,
-0.0218653567135334,
-0.00195919256657362,
0.03236447647213936,
0.011184394359588623,
0.01275948528200388,
0.030447199940681458,
-0.016770677641034126,
0.003470312338322401,
-0.009358358569443226,
0.006001841276884079,
0.018142998218536377,
-0.002325977198779583,
0.0004145912826061249,
-0.00977915246039629,
0.0009975323919206858,
-0.01092394907027483,
-0.005530893336981535,
0.023326851427555084,
-0.02622762881219387,
0.013639068230986595,
-0.007739459630101919,
0.015504999086260796,
-0.0017447025747969747,
-0.00859739538282156,
0.004145083483308554,
-0.021093901246786118,
0.0027195813599973917,
0.0015222616493701935,
0.017701877281069756,
-0.03216583654284477,
0.00492859398946166,
-0.0077635860070586205,
-0.0025047387462109327,
0.005435807630419731,
-0.009296288713812828,
0.00807633250951767,
-0.04216865450143814,
-0.0055623650550842285,
-0.008895893581211567,
-0.012895805761218071,
0.007585353218019009,
-0.008827518671751022,
-0.026594217866659164,
-0.014995207078754902,
-0.03176051378250122,
-0.016433456912636757,
0.002193387597799301,
0.0060858940705657005,
0.005990513600409031,
0.043926406651735306,
0.011794286780059338,
0.029718175530433655,
0.004704948049038649,
-0.005480293184518814,
-0.0016462292987853289,
-0.0029226094484329224,
0.00190558354370296,
-0.020868882536888123,
0.005112942773848772,
0.009503466077148914,
-0.01363331452012062,
-0.013426875695586205,
0.0017642754828557372,
-0.005394407548010349,
0.06649509817361832,
0.011220946907997131,
0.0013781790621578693,
-0.027355454862117767,
0.04421050101518631,
-0.007962423376739025,
-0.019921084865927696,
0.02128799632191658,
0.00025246618315577507,
0.031283121556043625,
-0.018558207899332047,
-0.005560740828514099,
-0.03652094304561615,
-0.004835418425500393,
0.0021024576853960752,
0.010709036141633987,
0.0017164184246212244,
-0.012253831140697002,
0.0015489491634070873,
0.011146158911287785,
-0.029474087059497833,
0.012071367353200912,
-0.004511964041739702,
0.015367751941084862,
0.005564692430198193,
-0.001969357021152973,
0.006595779675990343,
0.003857034258544445,
-0.020916437730193138,
-0.003062145784497261,
0.01953314244747162,
0.005334446206688881,
0.006353556644171476,
-0.006177636329084635,
-0.0019758695270866156,
-0.016903774812817574,
0.03076006844639778,
-0.00037639494985342026,
-0.0009972858242690563,
-0.022273331880569458,
-0.016980653628706932,
0.00042705622036010027,
0.000600359053350985,
0.0010595005005598068,
-0.021461069583892822,
0.010390005074441433,
-0.03079194948077202,
0.011160817928612232,
0.016113318502902985,
0.0014278087764978409,
-0.0041474695317447186,
-0.001229089917615056,
-0.00417625205591321,
-0.00806370098143816,
-0.01380118541419506,
0.023764263838529587,
0.01243993267416954,
0.006725146900862455,
-0.024410974234342575,
0.01275227777659893,
-0.0074729896150529385,
-0.004678509198129177,
-0.0018933528335765004,
-0.0027044699527323246,
-0.0040789395570755005,
-0.004359815735369921,
-0.026468785479664803,
0.03518103063106537,
-0.009796896949410439,
-0.007848508656024933,
0.0033166890498250723,
0.0008047439041547477,
-0.014960790984332561,
-0.010434860363602638,
-0.008504433557391167,
-0.00833466462790966,
-0.014237146824598312,
-0.013746332377195358,
0.014027368277311325,
0.0258182343095541,
-0.01340045128017664,
-0.0075398823246359825,
0.0035354201681911945,
0.012813474051654339,
-0.010800709947943687,
0.007475586608052254,
-0.002512105740606785,
0.009662586264312267,
0.02286941558122635,
0.019343215972185135,
0.008701365441083908,
0.00274076871573925,
-0.011228268966078758,
-0.00814075767993927,
-0.08179838955402374,
-0.011865092441439629,
0.02490858919918537,
-0.013441881164908409,
0.01715526171028614,
-0.0025498662143945694,
0.016238801181316376,
0.011305473744869232,
-0.02326907590031624,
-0.007591954432427883,
0.007732819765806198,
-0.012373007833957672,
-0.014059211127460003,
-0.00464449729770422,
0.004699302837252617,
0.0007748506031930447,
0.0035777532029896975,
-0.01892152428627014,
-0.019468341022729874,
0.02134329453110695,
-0.02576606348156929,
-0.022804267704486847,
-0.0024681545328348875,
-0.007501899264752865,
-0.010843660682439804,
0.012167765758931637,
-0.0036096866242587566,
-0.0018082322785630822,
-0.022128745913505554,
0.004472715780138969,
0.02739119529724121,
-0.051049843430519104,
-0.01042029820382595,
0.0070018707774579525,
-0.02011566050350666,
0.006213082000613213,
0.000051210285164415836,
-0.02651286870241165,
-0.0003982041962444782,
0.006862929090857506,
0.023985128849744797,
0.02357982099056244,
-0.01874968782067299,
-0.002234441926702857,
-0.006415133364498615,
0.026153409853577614,
0.011313295923173428,
-0.0061708735302090645,
0.01752210408449173,
0.01247918326407671,
0.006538219749927521,
-0.008131797425448895,
0.0064595723524689674,
0.012296474538743496,
-0.012717342004179955,
0.001116023282520473,
-0.007652156054973602,
0.002501287031918764,
-0.006450217217206955,
-0.012580080889165401,
0.014157234691083431,
-0.011409430764615536,
-0.0073980605229735374,
0.009152826853096485,
-0.040811747312545776,
-0.007182914298027754,
0.005654509179294109,
-0.005301846191287041,
-0.009860377758741379,
0.015347585082054138,
0.026254918426275253,
-0.021994464099407196,
-0.00026932917535305023,
0.0024704639799892902,
-0.01531379483640194,
-0.021442759782075882,
-0.01537790335714817,
-0.0021159877069294453,
-0.006321791559457779,
0.031902823597192764,
0.0029083634726703167,
-0.011983036994934082,
-0.006998944561928511,
-0.009559471160173416,
-0.024577569216489792,
-0.01849687471985817,
0.005707692354917526,
-0.02796550840139389,
0.0007775233825668693,
-0.01491918321698904,
-0.00010968931019306183,
-0.02746810019016266,
0.0038673668168485165,
0.0011552717769518495,
-0.0073278495110571384,
-0.021995192393660545,
0.017660334706306458,
-0.0030717120971530676,
0.007909349165856838,
0.007981793023645878,
-0.022779641672968864,
0.002489400329068303,
0.0016892468556761742,
-0.019468966871500015,
-0.00820930115878582,
0.00795478280633688,
-0.02082659862935543,
-0.007487007416784763,
0.001166380476206541,
-0.006456806790083647,
-0.03539071977138519,
-0.024163909256458282,
-0.0050514331087470055,
0.011219263076782227,
0.0003455296973697841,
0.005122191272675991,
0.0036719227209687233,
-0.003431549295783043,
0.0726066380739212,
-0.004418963100761175,
0.015802614390850067,
-0.009792160242795944,
-0.021909143775701523,
-0.0015477511333301663,
0.009096347726881504,
0.007094359491020441,
0.026395045220851898,
-0.031932562589645386,
0.012324728071689606,
0.016503069549798965,
0.01789316162467003,
0.022780366241931915,
0.0012490409426391125,
0.0028789734933525324,
0.0060950075276196,
-0.00927762407809496,
-0.03385690972208977,
-0.006630073767155409,
-0.007098148111253977,
0.02329106628894806,
-0.0014896057546138763,
0.014173852279782295,
-0.0065459320321679115,
-0.020148254930973053,
0.001394856721162796,
-0.013840963132679462,
-0.010955293662846088,
0.0016074867453426123,
0.013135873712599277,
0.018501095473766327,
-0.005564811639487743,
0.0068033491261303425,
0.01716805435717106,
0.016031548380851746,
-0.0015059311408549547,
0.004062002990394831,
0.00766417384147644,
0.0006996439769864082,
0.009669880382716656,
-0.01236986555159092,
0.02521544322371483,
0.007823011837899685,
-0.0017318051541224122,
-0.007334655150771141,
-0.012024653144180775,
-0.005373280495405197,
-0.029411625117063522,
0.011137917637825012,
-0.004015842918306589,
0.012413624674081802,
0.003653324209153652,
0.013871923089027405,
-0.0016280231066048145,
-0.0004933651071041822,
-0.013460769318044186,
-0.009965073317289352,
-0.026528552174568176,
0.033859215676784515,
-0.004360253922641277,
-0.016767987981438637,
-0.0052453940734267235,
0.00947140995413065,
0.006909695919603109,
0.007817229256033897,
-0.006054014898836613,
-0.016928942874073982,
0.029261495918035507,
0.001014096662402153,
-0.016327522695064545,
0.004485327284783125,
-0.008674370124936104,
0.001999929081648588,
0.001453349832445383,
-0.032162006944417953,
-0.009381260722875595,
-0.006925643887370825,
-0.008723931387066841,
0.005923672579228878,
-0.016436314210295677,
0.0034325120504945517,
-0.02008555643260479,
-0.009907035157084465,
0.010675875470042229,
0.01581178605556488,
-0.005296562798321247,
-0.07544750720262527,
-0.014132164418697357,
0.023696642369031906,
-0.005704299546778202,
-0.020060939714312553,
0.01175080705434084,
-0.016711972653865814,
-0.01555178314447403,
0.001376352971419692,
-0.011861924082040787,
0.026715993881225586,
0.027595575898885727,
-0.00491616316139698,
-0.004581959918141365,
0.010807137005031109,
0.0200965479016304,
0.014449347741901875,
-0.011295068077743053,
-0.008746628649532795,
0.003533013630658388,
0.0013488151598721743,
0.016974689438939095,
-0.041413307189941406,
-0.009176132269203663,
-0.004527736455202103,
-0.08111195266246796,
0.006827755831182003,
0.000027090194635093212,
-0.043513596057891846,
-0.016678838059306145,
-0.03023216314613819,
0.0014204139588400722,
-0.02605816349387169,
0.03159429505467415,
-0.015935825183987617,
-0.04110439494252205,
0.010802171193063259,
0.03150220960378647,
0.011897757649421692,
0.00097293546423316,
0.0007963257958181202,
0.0062606241554021835,
-0.03200111538171768,
-0.0028348215855658054,
0.021185150370001793,
0.0005776116158813238,
0.031927257776260376,
-0.01053532399237156,
0.016770223155617714,
-0.008753916248679161,
-0.01419786922633648,
0.0006238226778805256,
0.007118661887943745,
-0.011021068319678307,
-0.0028020211029797792,
0.018138229846954346,
0.004053971264511347,
-0.0075675565749406815,
0.003719879547134042,
-0.002287701703608036,
-0.006319371983408928,
-0.009584901854395866,
-0.0015078841242939234,
-0.01435656938701868,
0.0039557795971632,
0.008607352152466774,
-0.0027784383855760098,
-0.023018773645162582,
-0.010674430057406425,
-0.012408489361405373,
-0.011917857453227043,
0.004639545921236277,
0.00656710471957922,
0.011412709951400757,
0.007290912326425314,
0.0033007613383233547,
0.0012702234089374542,
0.00820980966091156,
-0.02123255655169487,
-0.000009780284017324448,
-0.0015780096873641014,
-0.01245983224362135,
-0.017109284177422523,
0.014254176989197731,
-0.005726648960262537,
-0.0016272139037027955,
0.019061408936977386,
0.020151207223534584,
0.07113392651081085,
-0.029448172077536583,
0.01733340509235859,
0.010634511709213257,
-0.01838275045156479,
-0.0035167993046343327,
0.016598721966147423,
0.026778288185596466,
-0.0008380019571632147,
0.005335145629942417,
-0.013036444783210754,
-0.011099083349108696,
0.024987006559967995,
0.0032748060766607523,
0.0017828471027314663,
0.006324894726276398,
0.009031522087752819,
0.031021729111671448,
-0.011427035555243492,
-0.02863108180463314,
0.024102797731757164,
0.0015195989981293678,
-0.009517574682831764,
0.010280112735927105,
0.043595366179943085,
-0.030251052230596542,
-0.028970159590244293,
0.004452447406947613,
0.009238943457603455,
0.003342169104143977,
0.0019216497894376516,
0.01803738996386528,
-0.0016203862614929676,
-0.009234383702278137,
0.01211604755371809,
-0.025715738534927368,
0.0010789076332002878,
0.00438814889639616,
-0.005609723739326,
-0.003677613800391555,
0.02119177207350731,
-0.019150935113430023,
0.0011398736387491226,
-0.030457913875579834,
-0.009170519188046455,
-0.005797329358756542,
0.00229179160669446,
-0.01804172247648239,
0.009649691171944141,
0.004018144682049751,
-0.018917132169008255,
-0.0005035888170823455,
-0.041581347584724426,
-0.013739329762756824,
0.005649627186357975,
0.0065087187103927135,
-0.024636194109916687,
-0.0008313005091622472,
0.03640817105770111,
-0.032916754484176636,
0.0013545798137784004,
-0.020826779305934906,
0.021937794983386993,
0.0004523182869888842,
0.017446499317884445,
0.012916568666696548,
0.001959031680598855,
-0.015874722972512245,
0.0047432975843548775,
0.010052748024463654,
-0.01940128207206726,
-0.004564773291349411,
-0.0024370895698666573,
0.007868114858865738,
0.02600906789302826,
-0.020839013159275055,
0.0014927671290934086,
-0.006509013008326292,
0.015469665639102459,
0.00490558473393321,
-0.013311588205397129,
0.0032653766684234142,
0.004076499491930008,
0.006003184709697962,
-0.011738527566194534,
0.01326972246170044,
0.014761491678655148,
-0.007236597593873739,
-0.004416760988533497,
0.0034390310756862164,
-0.006805925630033016,
0.014804333448410034,
-0.002206492004916072,
-0.0021373508498072624,
-0.001874505658634007,
0.0353698767721653,
-0.008344162255525589,
0.006549796089529991,
0.015468912199139595,
0.004125327803194523,
-0.0031340508721768856,
0.022011995315551758,
-0.008109504356980324,
0.020943209528923035,
0.02312779612839222,
-0.0013686404563486576,
-0.00540555827319622,
0.0013255149824544787,
-0.00006066635251045227,
0.017240412533283234,
0.005963615141808987,
-0.008432550355792046,
0.0028206189163029194,
-0.01516763586550951,
0.014207680709660053,
0.007897796109318733,
0.0012189610861241817,
-0.011547042988240719,
0.006752131041139364,
-0.012477914802730083,
-0.02084936946630478,
-0.006838143337517977,
0.010025412775576115,
0.01763186976313591,
0.016467653214931488,
-0.0034223124384880066,
-0.008136262185871601,
0.029105402529239655,
0.010081248357892036,
0.007195618003606796,
0.012913977727293968,
-0.002116929739713669,
0.03478899598121643,
0.0004122254904359579,
0.005099455825984478,
-0.014332941733300686,
-0.016842471435666084,
-0.003764985827729106,
0.01610128954052925,
0.0005505889421328902,
-0.004846464842557907,
-0.004334079567342997,
-0.005251465365290642,
0.00475471094250679,
0.00732625974342227,
-0.014408946968615055,
0.0248003788292408,
0.06282024085521698,
0.003658807137981057,
0.011998665519058704,
-0.02535167708992958,
0.02037443034350872,
-0.01974339596927166,
-0.004325522109866142,
0.002395537681877613,
0.03888130933046341,
0.0004656627424992621,
-0.011272740550339222,
-0.01798119954764843,
-0.018838757649064064,
0.00553875369951129,
-0.012015441432595253,
0.012390528805553913,
-0.0009281840175390244,
-0.005648292601108551,
0.019042303785681725,
0.004526772536337376,
0.01348115224391222,
-0.009245218709111214,
0.006385542452335358,
0.014416981488466263,
-0.003940077498555183,
-0.021776709705591202,
0.002390502020716667,
-0.019958244636654854,
0.003960120026022196,
-0.008721941150724888,
0.012324037961661816,
-0.041310254484415054,
-0.007818966172635555,
-0.0016698907129466534,
-0.0003192053991369903,
-0.022319478914141655,
-0.008584453724324703,
0.009485206566751003,
0.0008832240710034966,
-0.013343757018446922,
0.009000888094305992,
-0.005184071138501167,
0.0101834237575531,
-0.011729277670383453,
-0.00783141702413559,
-0.017120681703090668,
0.010323286056518555,
0.009240537881851196,
0.0027649374678730965,
0.016408849507570267,
-0.021622750908136368,
-0.0018976726569235325,
0.005731808952987194,
0.019034162163734436,
-0.002471009735018015
] | [
0.13847072422504425,
0.23131442070007324,
-0.010758260264992714,
0.0627809464931488,
0.026303445920348167,
0.3383585810661316,
-0.20272094011306763,
-0.7079533934593201,
0.17990858852863312,
-0.5804736614227295,
0.13726872205734253,
0.8114930987358093,
0.17570415139198303,
-0.1618938446044922,
-0.15072333812713623,
0.7542061805725098,
0.9298506379127502,
0.017058085650205612,
0.17801181972026825,
-0.7461683750152588,
-0.34112170338630676,
0.08119387924671173,
0.11530283838510513,
-0.1949881911277771,
0.47318390011787415,
0.6435494422912598,
0.008823832497000694,
0.18961337208747864,
-0.18842002749443054,
-0.3247690796852112,
-0.05120449513196945,
0.21007609367370605,
-0.1275130659341812,
-0.06064676120877266,
0.11246772855520248,
0.1417512148618698,
0.17484895884990692,
-0.36582210659980774,
0.14197911322116852,
-0.2252407670021057,
-0.4705493748188019,
0.6631647348403931,
-0.16070634126663208,
0.5319249629974365,
0.12666121125221252,
-0.22502481937408447,
-1.3162347078323364,
-0.3309370279312134,
-0.4305073916912079,
0.17876948416233063,
0.18642652034759521,
0.5419475436210632,
0.3709946870803833,
0.23915407061576843,
-0.06038013473153114,
0.3993377983570099,
-0.010181120596826077,
-0.3636363744735718,
-0.03789167478680611,
-0.4426630139350891,
0.29623618721961975,
-0.1203308179974556,
0.14772865176200867,
0.6828480362892151,
0.3489302694797516,
0.22992976009845734,
0.14491000771522522,
-0.18804597854614258,
-0.1368696689605713,
-0.2794130742549896,
-0.21689853072166443,
-0.3436279892921448,
-0.09394559264183044,
0.5218448638916016,
-0.21132715046405792,
-0.1721113622188568,
-0.0807521864771843,
-0.09572333842515945,
-0.17485471069812775,
-0.29932600259780884,
0.3627301752567291,
-0.00499558774754405,
0.1688028872013092,
-0.5000220537185669,
0.5640284419059753,
0.12784317135810852,
0.022505884990096092,
0.34750497341156006,
-0.5796900987625122,
0.3031380772590637,
-0.17922016978263855,
-0.40145784616470337,
0.15056858956813812,
0.28477010130882263,
0.24321261048316956,
-0.29266634583473206,
0.013438532128930092,
-0.2202526479959488,
0.4120534062385559,
0.20644235610961914,
-0.005173064302653074,
-0.024550283327698708,
0.009998475201427937,
-0.08754243701696396,
-0.7598803043365479,
-0.4009084105491638,
0.02664215862751007,
-0.9371641874313354,
-0.10116927325725555,
0.4293968975543976,
-0.8055891990661621,
0.5382604002952576,
0.1033409982919693,
-0.3905240595340729,
-0.2939469814300537,
0.43521755933761597,
0.08869234472513199,
0.06032031029462814,
-0.6486940979957581,
0.331879198551178,
-0.021928593516349792,
0.825169563293457,
0.08380330353975296,
0.24457000195980072,
0.40287861227989197,
0.14644046127796173,
0.9038569927215576,
0.2614562511444092,
0.04688660800457001,
0.09633723646402359,
0.10789254307746887,
0.33606576919555664,
-0.7935240268707275,
0.0636235773563385,
-0.6694262623786926,
-0.2815704047679901,
-0.15429586172103882,
0.29733675718307495,
0.399044930934906,
0.29361197352409363,
-0.1149568185210228,
-0.8252140283584595,
-0.019386859610676765,
-0.5565534234046936,
0.23525545001029968,
-0.5218753814697266,
0.18824154138565063,
-0.14281857013702393,
-0.4188441038131714,
0.1945083737373352,
0.6425687670707703,
0.30077287554740906,
-0.5110628604888916,
0.16518066823482513,
-0.04922301322221756,
0.6723681092262268,
0.37116682529449463,
0.010585724376142025,
-0.30844631791114807,
-0.00022661018010694534,
0.9302790760993958,
0.2247823029756546,
-0.6881090998649597,
0.103155717253685,
0.28003397583961487,
-0.028672978281974792,
0.10541271418333054,
0.038219206035137177,
0.6551311612129211,
0.08555158227682114,
-0.4499026834964752,
-0.05057157203555107,
0.04885284602642059,
-0.26437968015670776,
-0.04369453713297844,
0.4294091463088989,
0.8200210332870483,
0.39374497532844543,
0.45285066962242126,
-0.08821781724691391,
-0.32660287618637085,
-0.30010002851486206,
-0.2314598560333252,
-1.2158433198928833,
-0.05298169329762459,
-0.1394956409931183,
0.6817176938056946,
-0.2355332225561142,
0.13834726810455322,
0.5224473476409912,
-0.10217157751321793,
-0.18159888684749603,
0.2703441381454468,
-1.196969747543335,
1.5588384866714478,
-0.25461915135383606,
-0.04073002189397812,
1.102909803390503,
-0.41484761238098145,
-0.436386376619339,
0.006133085582405329,
0.3542119860649109,
0.8748166561126709,
0.37358084321022034,
-1.0760846138000488,
-0.3206811845302582,
0.12953351438045502,
-0.45979052782058716,
-0.48017027974128723,
0.5051048398017883,
0.4614354372024536,
0.17242440581321716,
-0.3048012852668762,
-0.5603768229484558,
0.3765672743320465,
-0.35491427779197693,
0.39568063616752625,
0.6743109226226807,
-0.0694507360458374,
-0.16517828404903412,
0.8456008434295654,
0.0440838523209095,
0.5301930904388428,
0.8380115032196045,
0.0060311369597911835,
0.30465105175971985,
0.6601979732513428,
0.11463753879070282,
0.7157605290412903,
-0.595352053642273,
0.48882830142974854,
-0.04983288049697876,
0.6291600465774536,
-0.28425154089927673,
-0.10488259047269821,
0.16927693784236908,
-0.2941266894340515,
-0.12404237687587738,
-0.1691702902317047,
-0.5332781076431274,
0.10292254388332367,
0.20094448328018188,
-0.5075186491012573,
0.37269556522369385,
0.7025676369667053,
-0.37979093194007874,
-0.0827522948384285,
0.40233585238456726,
-0.7764760255813599,
-0.026779966428875923,
0.12207479774951935,
0.6191861629486084,
0.5219511985778809,
-0.3367568850517273,
-0.15440140664577484,
-0.16937093436717987,
-0.26475149393081665,
-0.3611951470375061,
0.19182293117046356,
-0.056917302310466766,
-0.325278103351593,
0.2663838863372803,
0.40960413217544556,
-0.04967852681875229,
0.2856117784976959,
-0.39510151743888855,
-0.4566842317581177,
-0.7537243962287903,
0.3772294223308563,
0.6881338953971863,
0.4254775643348694,
-0.18418703973293304,
-0.7723682522773743,
-0.07307802885770798,
-0.09533315151929855,
-1.1878966093063354,
0.15533562004566193,
0.65622478723526,
-0.36233648657798767,
-0.3830470144748688,
0.011699448339641094,
0.18526354432106018,
0.8416548371315002,
0.19875483214855194,
-0.3324720561504364,
-0.14237947762012482,
-0.08518484979867935,
-0.7272358536720276,
-0.23335683345794678,
0.19719336926937103,
-0.3874230682849884,
0.5538733005523682,
-0.625331699848175,
-0.6965445876121521,
0.6415936946868896,
0.23084697127342224,
-0.8298863172531128,
0.39982959628105164,
0.18059591948986053,
-0.372272253036499,
0.1944810003042221,
0.05984921380877495,
0.3950124680995941,
0.19627360999584198,
0.16652841866016388,
-0.6052411198616028,
-0.2037852257490158,
0.22610436379909515,
-5.713854789733887,
-0.5995506048202515,
-0.20831942558288574,
0.13588592410087585,
-0.05299090966582298,
0.23787061870098114,
1.082693099975586,
-0.41714319586753845,
0.1977793425321579,
-0.44351455569267273,
0.19704213738441467,
0.2040935754776001,
0.09494615346193314,
0.46306201815605164,
0.13838687539100647,
0.31642183661460876,
-0.1318281888961792,
-0.29650455713272095,
0.3656834363937378,
0.022975623607635498,
0.48748520016670227,
-0.3565271496772766,
-0.29269349575042725,
0.7413504123687744,
0.04875116050243378,
0.0899757668375969,
-1.342616319656372,
0.8607128858566284,
-0.4700377285480499,
-0.05174025893211365,
0.3890904188156128,
-0.4346137046813965,
-0.24572539329528809,
-0.5539949536323547,
0.27148762345314026,
0.005590771324932575,
-0.0395171120762825,
0.4352336823940277,
0.11782315373420715,
-0.29555052518844604,
0.4606471657752991,
0.2546345591545105,
-0.335317462682724,
-0.6219670176506042,
0.39875897765159607,
0.4642336070537567,
0.25586748123168945,
0.23571527004241943,
-0.06299816071987152,
0.7373555302619934,
-0.05894218757748604,
0.2950080633163452,
0.0014565959572792053,
0.39884305000305176,
0.043502986431121826,
-0.7031575441360474,
-0.0034483193885535,
0.4097854793071747,
-0.5446209907531738,
0.49801889061927795,
0.028420696035027504,
-0.645317018032074,
0.046665191650390625,
-0.6930961608886719,
-0.5069501996040344,
0.5035253167152405,
-0.8305281400680542,
-0.6122901439666748,
-0.11902807652950287,
0.0726674348115921,
-0.3476245105266571,
0.49408048391342163,
0.06402599066495895,
-0.8865174651145935,
0.27659568190574646,
-0.6612133383750916,
0.34586504101753235,
0.47807106375694275,
0.11068854480981827,
-0.01252816990017891,
-0.09065127372741699,
-0.2187226265668869,
-0.3085692226886749,
0.3256097137928009,
-0.020394152030348778,
-0.2138230800628662,
-0.18561573326587677,
-0.08637768775224686,
-0.9453122019767761,
-0.0356307215988636,
0.258518248796463,
-0.2517094910144806,
0.35074111819267273,
0.5228130221366882,
0.4496903419494629,
0.43058210611343384,
0.5219546556472778,
0.14888329803943634,
0.5516955852508545,
-0.18275678157806396,
0.5581011176109314,
-0.009675802662968636,
-0.018216541036963463,
-0.9257358312606812,
-0.2706385552883148,
-0.157801553606987,
-0.38181352615356445,
-0.01070118136703968,
0.6585879921913147,
-1.0435411930084229,
-0.19090008735656738,
0.06629526615142822,
-0.509209156036377,
-0.44233858585357666,
0.07704377919435501,
0.0959281250834465,
-0.6100975275039673,
-0.11780387163162231,
0.38444438576698303,
-0.07371301203966141,
-0.043372638523578644,
-0.10162145644426346,
-0.2022472769021988,
0.25255438685417175,
0.12645672261714935,
-0.48414042592048645,
0.2406356930732727,
0.11804074794054031,
-0.25446897745132446,
0.5723516941070557,
0.3351982533931732,
0.6156792044639587,
-0.5036397576332092,
-0.012180914171040058,
0.46035531163215637,
-0.596514105796814,
-0.33224672079086304,
0.8628630042076111,
0.17413115501403809,
-0.04928192123770714,
0.15706998109817505,
-0.14776325225830078,
-0.11130018532276154,
-0.3166065812110901,
-0.07328984886407852,
0.38276365399360657,
-0.3263545036315918,
0.2590441107749939,
-0.03457479923963547,
0.6861937642097473,
-0.011890153400599957,
0.10915467143058777,
-0.16192151606082916,
-0.21746045351028442,
-0.4459403157234192,
0.10493751615285873,
0.37658819556236267,
0.18800804018974304,
0.08272133767604828,
-0.49077191948890686,
0.43261197209358215,
-0.050819169729948044,
-0.8976994156837463,
-0.3697352409362793,
0.1588670015335083,
0.11438219994306564,
-0.8469884395599365,
-0.008343417197465897,
-0.09989961981773376,
0.2889668345451355,
-0.2672452926635742,
-0.10515481978654861,
-0.1890188753604889,
-0.097744882106781,
-0.11950482428073883,
0.046898048371076584,
0.16872620582580566,
0.25278371572494507,
-0.48414522409439087,
0.0757482498884201,
0.48663434386253357,
-1.0802160501480103,
-0.10594901442527771,
0.1472969651222229,
0.4431985318660736,
-0.1722245067358017,
0.058225564658641815,
-0.1291763186454773,
-0.4922299087047577,
-0.3190899193286896,
0.01692456379532814,
-0.14396712183952332,
0.70591801404953,
-0.22363685071468353,
-0.3705116808414459,
-0.266059011220932,
0.3447008728981018,
0.5060862302780151,
-0.2610797584056854,
-0.5348232984542847,
0.38079845905303955,
0.3952826261520386,
-0.38413912057876587,
0.43571555614471436,
0.17593912780284882,
-0.27102503180503845,
0.028168419376015663,
0.11870957165956497,
-0.2495090663433075,
0.05694712698459625,
-0.403769850730896,
-0.2233595997095108,
-0.2522440552711487,
0.34837085008621216,
-0.3764926493167877,
-0.08148333430290222,
-0.08273708820343018,
-0.20117449760437012,
-0.2516286373138428,
0.06632163375616074,
0.9422738552093506,
-0.004048494156450033,
-0.26619282364845276,
0.15930619835853577,
-0.3432539701461792,
0.05752820521593094,
0.6271553635597229,
-0.8470593690872192,
0.22644352912902832,
-0.008118843659758568,
-0.6721115708351135,
-0.25466835498809814,
-0.1252993643283844,
0.024400776252150536,
-0.32233530282974243,
-0.3953965902328491,
-0.6943879723548889,
0.4402155578136444,
0.4378078877925873,
0.3295259177684784,
-0.5851723551750183,
0.45585283637046814,
0.04951031506061554,
-0.5976676940917969,
0.259010374546051,
0.16013401746749878,
0.47639361023902893,
-0.6654674410820007,
-0.6814791560173035,
0.08778142929077148,
-0.12884069979190826,
-0.2409844696521759,
0.12021041661500931,
-0.04837840050458908,
0.5167249441146851,
0.3172321021556854,
-0.6885432004928589,
-0.3631458878517151,
-0.2815122604370117,
0.5607404708862305,
-0.24996468424797058,
-0.22203756868839264,
-0.398262083530426,
-0.39890390634536743,
1.0214488506317139,
-0.02631191536784172,
-0.2163657546043396,
-0.2160097360610962,
-0.41165006160736084,
-0.6057548522949219,
-0.06089872494339943,
0.04282248392701149,
0.02449420467019081,
0.20006129145622253,
0.373271644115448,
-0.21229906380176544,
0.24016687273979187,
-0.4798225164413452,
0.38145387172698975,
0.10244505107402802,
-0.2952970564365387,
-0.49021854996681213,
0.3112926781177521,
-0.1634233146905899,
0.38733941316604614,
-0.8784574270248413,
-0.012050229124724865,
0.3166920840740204,
-0.007421240676194429,
-0.05026236176490784,
-0.2547125816345215,
0.15373115241527557,
-1.2185862064361572,
0.0994899645447731,
-0.2549952268600464,
0.38510656356811523,
0.12882904708385468,
0.08057042211294174,
-0.2171718329191208,
0.19075173139572144,
0.04845515266060829,
0.2733730971813202,
0.6486981511116028,
-0.4746496379375458,
0.1748872995376587,
0.8312488794326782,
0.28486013412475586,
-0.04869416356086731,
-0.5080546736717224,
0.287416011095047,
0.444009006023407,
-0.34769055247306824,
0.33816877007484436,
0.6004263758659363,
-0.4151670038700104,
0.11162793636322021,
-0.17602892220020294,
-0.1605233997106552,
0.411085844039917,
-0.0860072448849678,
-0.09068819135427475,
0.24937114119529724,
0.8808049559593201,
-0.29640263319015503,
-0.6268039345741272,
0.2217872589826584,
-0.28373658657073975,
0.19279725849628448,
0.09193892031908035,
0.3078850209712982,
0.5331204533576965,
1.052268147468567,
0.2732072174549103,
0.1055951938033104,
0.040133073925971985,
0.4704951345920563,
-0.09228375554084778,
-0.5283701419830322,
-0.04775971919298172,
0.214914932847023,
0.7425139546394348,
0.37924477458000183,
-0.1813964545726776,
0.10492772608995438,
0.02029741182923317,
0.5296850204467773,
0.21184217929840088,
-0.09726311266422272,
-0.13018174469470978,
0.3392277657985687,
-0.19824917614459991,
0.15930254757404327,
0.19797876477241516,
0.01639692857861519,
-0.07323980331420898,
0.38819777965545654,
0.2040105015039444,
-0.3894825875759125,
0.019813891500234604,
-0.11825747042894363,
0.19334596395492554,
0.6011346578598022,
-0.3841862976551056,
0.26225730776786804,
-0.3203538656234741,
0.1678154319524765,
0.6976454854011536,
0.2500836253166199,
0.2722232937812805,
0.22343431413173676,
-0.36003902554512024,
0.17944970726966858,
-0.4594724178314209,
0.004378674551844597,
-0.02015109919011593,
-0.7051147818565369,
0.021586285904049873,
-0.227204829454422,
0.45137152075767517,
0.3617601990699768,
-0.21005308628082275,
-0.22054354846477509,
-0.5259931087493896,
-0.8295262455940247,
-0.020833471789956093,
0.11154124140739441,
-0.24473360180854797,
0.1467444896697998,
0.04847239330410957,
0.15265201032161713,
-0.3281683921813965,
-0.664147675037384,
0.11530930548906326,
0.1252986192703247,
-0.301977276802063,
0.068884938955307,
0.14352193474769592,
0.5146235823631287,
0.684827446937561,
0.04597162455320358,
-0.43590113520622253,
-0.1684211641550064,
-0.36359333992004395,
0.40197744965553284,
0.07195522636175156,
0.3654645085334778,
-0.28025174140930176,
0.3901759684085846,
-0.3885282278060913,
-0.36469170451164246,
0.28333359956741333,
0.3554914891719818,
-0.2324584275484085,
0.3072358965873718,
0.2876288592815399,
0.3417283892631531,
0.3422664701938629,
-0.5759122371673584,
0.09498367458581924,
-0.2971896827220917,
-0.4560658037662506,
-0.1508239060640335,
0.5773066878318787,
0.2211158573627472,
-0.43016889691352844,
-0.31475189328193665,
0.17557768523693085,
0.3119153082370758,
0.009412668645381927,
0.10624755173921585,
-0.28749462962150574,
-0.6896315217018127,
-0.6285660266876221,
0.4278624951839447,
-0.31418272852897644,
0.2841784358024597,
0.2123834192752838,
0.26597049832344055,
0.48296424746513367,
0.03820160776376724,
-0.7097697854042053,
-0.23658210039138794,
0.24937894940376282,
0.3666682839393616,
-0.4570416808128357,
0.00658468808978796,
0.2616032063961029,
-0.7891193628311157,
-0.5547216534614563,
0.8819816708564758,
0.06156802177429199,
-0.27993932366371155,
-0.5388511419296265,
-0.48172807693481445,
-0.5297060608863831,
-0.19635121524333954,
-0.058614332228899,
-0.22360165417194366,
-0.07529710233211517,
-0.2471986711025238
] |
As women of childbearing age have become heavier, the trade-off between maternal and child health created by variation in gestational weight gain has become more difficult to reconcile. Weight Gain During Pregnancy responds to the need for a reexamination of the 1990 Institute of Medicine guidelines for weight gain during pregnancy. It builds on the conceptual framework that underscored the 1990 weight gain guidelines and addresses the need to update them through a comprehensive review of the literature and independent analyses of existing databases. The book explores relationships between weight gain during pregnancy and a variety of factors (e.g., the mother's weight and height before pregnancy) and places this in the context of the health of the infant and the mother, presenting specific, updated target ranges for weight gain during pregnancy and guidelines for proper measurement. New features of this book include a specific range of recommended gain for obese women. Weight Gain During Pregnancy is intended to assist practitioners who care for women of childbearing age, policy makers, educators, researchers, and the pregnant women themselves to understand the role of gestational weight gain and to provide them with the tools needed to promote optimal pregnancy outcomes. | [
-0.009363780729472637,
0.008911305107176304,
-0.010895086452364922,
0.01664556935429573,
0.0120848398655653,
-0.0179149080067873,
0.005670145619660616,
-0.01868228241801262,
-0.011282266117632389,
-0.02022487297654152,
0.0015964570920914412,
0.009170702658593655,
-0.0111188143491745,
-0.0035452411975711584,
-0.01307955663651228,
-0.0158613920211792,
-0.0036724067758768797,
0.016672857105731964,
0.007460416294634342,
-0.007604551501572132,
-0.012641889974474907,
-0.0070031145587563515,
0.006971369963139296,
-0.011888071894645691,
0.0019456271547824144,
0.015908489003777504,
0.018981989473104477,
-0.01114482432603836,
0.0016928124241530895,
-0.007409990765154362,
0.002751103835180402,
0.002408483996987343,
0.005647674202919006,
0.0044771283864974976,
0.008560894057154655,
0.017831776291131973,
-0.00022269663168117404,
0.011118209920823574,
-0.012818166986107826,
-0.002520533511415124,
0.03123542293906212,
-0.0013952904846519232,
0.002800559625029564,
0.00582708977162838,
-0.0036672356072813272,
0.005133991129696369,
-0.003695596242323518,
-0.015678739175200462,
-0.016105245798826218,
0.0030459475237876177,
-0.01008223183453083,
-0.014208320528268814,
-0.004264891147613525,
0.009546809829771519,
-0.0035087678115814924,
0.0057646967470645905,
0.015566893853247166,
0.008461680263280869,
-0.00870771799236536,
0.0008829302387312055,
0.0033186592627316713,
0.016412369906902313,
0.010103978216648102,
0.012450063601136208,
0.00013228971511125565,
-0.06796687841415405,
0.020587585866451263,
-0.02016270160675049,
-0.011370347812771797,
0.016192300245165825,
0.008374637924134731,
0.004231998696923256,
-0.00429752841591835,
-0.01361110433936119,
-0.0023661674931645393,
0.0254412442445755,
-0.010781785473227501,
-0.022296279668807983,
-0.005895350128412247,
0.011630577966570854,
-0.000042211031541228294,
-0.00031486281659454107,
-0.009669419378042221,
0.011658374220132828,
-0.0023704878985881805,
-0.008135812357068062,
-0.01038833986967802,
0.0046170549467206,
0.005018370226025581,
0.011825842782855034,
-0.002069997601211071,
0.00519218435510993,
0.017341066151857376,
-0.00665957760065794,
-0.020333677530288696,
0.013617532327771187,
0.0030588055960834026,
0.00019934400916099548,
0.016253121197223663,
0.0001309579238295555,
-0.005357261747121811,
0.007963101379573345,
0.010996882803738117,
-0.02884748950600624,
0.019746411591768265,
0.0030718082562088966,
-0.008029645308852196,
0.017043225467205048,
-0.01835189014673233,
0.0010597693035379052,
0.003348809899762273,
0.0030458271503448486,
0.005712715908885002,
-0.01878119632601738,
0.015424858778715134,
0.027918044477701187,
0.010327417403459549,
0.0001604277640581131,
-0.002005781279876828,
0.0018790904432535172,
0.020643731579184532,
-0.0049218470230698586,
0.00240523973479867,
0.02453128807246685,
-0.0012198230251669884,
0.0017823276575654745,
-0.004050487652420998,
-0.005123407579958439,
-0.008252819068729877,
0.01265348494052887,
-0.005889158230274916,
0.0008299881592392921,
-0.004701795522123575,
-0.00317565118893981,
0.010406918823719025,
-0.004202698357403278,
-0.002051827497780323,
-0.010783289559185505,
-0.0015742662362754345,
0.0020807383116334677,
0.005187016911804676,
0.0036923971492797136,
-0.0006462287856265903,
-0.003219128819182515,
-0.0007748111966066062,
-0.0029449150897562504,
-0.01986057125031948,
0.018500633537769318,
-0.005417528096586466,
-0.0024369247257709503,
0.013195193372666836,
0.008389417082071304,
-0.0014940437395125628,
0.0024716416373848915,
0.006298010237514973,
-0.016881480813026428,
-0.003124252427369356,
0.015114471316337585,
-0.0065769716165959835,
-0.0004351192619651556,
0.0013820615131407976,
0.004159434698522091,
0.0031708250753581524,
0.006399022880941629,
0.00496448902413249,
-0.009561048820614815,
0.003057338297367096,
0.007457353640347719,
0.007123629096895456,
0.0007349846418946981,
-0.008097229525446892,
0.0029520445968955755,
-0.0224064439535141,
0.0039569842629134655,
0.003806968219578266,
0.007329910062253475,
-0.013673026114702225,
0.0056755878031253815,
0.00004854891449213028,
0.06716272234916687,
-0.0008417426142841578,
-0.004086867906153202,
-0.05184108018875122,
0.0071238805539906025,
-0.008381685242056847,
0.0001471692812629044,
0.020601313561201096,
-0.0020463336259126663,
0.008485930040478706,
-0.003253976348787546,
0.002720051445066929,
0.0042071896605193615,
0.013600019738078117,
-0.000763466814532876,
-0.011313623748719692,
0.002226180164143443,
0.006991194561123848,
-0.006142716854810715,
-0.017799891531467438,
-0.015576372854411602,
-0.030632324516773224,
-0.004865697585046291,
0.0075107356533408165,
0.010211200453341007,
-0.0032191139180213213,
0.0007838811725378036,
-0.009834610857069492,
-0.0010577624198049307,
-0.0013101465301588178,
-0.00022142264060676098,
0.0010093856835737824,
0.01037196908146143,
-0.01597455143928528,
-0.004406978376209736,
0.03321780636906624,
-0.010611127130687237,
-0.003034386085346341,
-0.018865052610635757,
0.0003740541578736156,
-0.01814010925590992,
0.009710162878036499,
0.0199139341711998,
0.013318709097802639,
-0.01756335236132145,
-0.0010309969075024128,
-0.022042401134967804,
-0.005797745659947395,
0.007257121615111828,
-0.0010968437418341637,
0.002228350844234228,
-0.009041892364621162,
-0.011603652499616146,
-0.0011391958687454462,
0.02214811183512211,
-0.008984125219285488,
0.0011895769275724888,
0.004561195615679026,
-0.0012204195372760296,
0.011519358493387699,
-0.005795174278318882,
0.003224239917472005,
0.008931225165724754,
0.014966278336942196,
-0.019333066418766975,
0.01359487883746624,
-0.007284494582563639,
0.006237896624952555,
0.016260450705885887,
-0.0028904022183269262,
-0.00189063954167068,
-0.00106974714435637,
-0.02275051735341549,
-0.003032765118405223,
-0.007065253332257271,
-0.015976179391145706,
0.008394231088459492,
-0.0081993592903018,
-0.0007519195787608624,
0.02233005501329899,
-0.007345942780375481,
0.007786039728671312,
0.004152654204517603,
-0.006166582927107811,
-0.008561166003346443,
-0.012124686501920223,
0.023920975625514984,
0.0027874198276549578,
-0.0008344831876456738,
-0.002999851480126381,
0.022772567346692085,
0.0010162924882024527,
-0.008067427203059196,
-0.0006969998357817531,
-0.08207888901233673,
-0.013611141592264175,
-0.009890618734061718,
-0.0173833929002285,
0.0028357559349387884,
0.006166405044496059,
0.012514917179942131,
-0.012698521837592125,
-0.0016288552433252335,
-0.004259702283889055,
0.004689405672252178,
-0.009709257632493973,
-0.003452659584581852,
0.034007079899311066,
0.0032865304965525866,
0.0034652354661375284,
0.0018692647572606802,
-0.02906946837902069,
-0.0036339228972792625,
0.013494536280632019,
0.007770628668367863,
-0.01627575419843197,
0.0009990234393626451,
-0.012765614315867424,
0.004978294484317303,
0.00934118963778019,
0.002736123977228999,
-0.0072335535660386086,
0.010455766692757607,
0.01207832619547844,
0.01383446715772152,
-0.011368811130523682,
0.002044863533228636,
0.005809542257338762,
-0.014797357842326164,
-0.0059368796646595,
-0.008289998397231102,
-0.018793385475873947,
-0.008413954637944698,
-0.0023980396799743176,
-0.00601966492831707,
0.008824888616800308,
0.001241658115759492,
-0.009588237851858139,
0.012755153700709343,
0.012015916407108307,
0.003948270808905363,
0.021610138937830925,
0.002644614316523075,
0.0032632723450660706,
0.015100546181201935,
-0.003490881994366646,
0.007908270694315434,
0.004274450708180666,
-0.0075385114178061485,
-0.009384119883179665,
0.018527917563915253,
-0.0021092703100293875,
-0.007955450564622879,
-0.007479269523173571,
0.01030477974563837,
0.007370868232101202,
-0.011548226699233055,
0.009424022398889065,
-0.0037201964296400547,
-0.0016913949511945248,
0.0010977243073284626,
-0.0020561194978654385,
-0.003697591368108988,
-0.0015979555901139975,
0.012900818139314651,
-0.013227101415395737,
0.0024754873011261225,
-0.0023778164759278297,
0.00045576225966215134,
-0.005177998915314674,
-0.007256363984197378,
0.00028314872179180384,
0.020420469343662262,
0.0038317551370710135,
-0.0023200272116810083,
-0.01339462399482727,
-0.002675448777154088,
-0.010353774763643742,
-0.006616470869630575,
0.026339244097471237,
0.009425620548427105,
0.010007649660110474,
0.0033311196602880955,
-0.011532673612236977,
-0.01728769764304161,
0.01270901970565319,
-0.005315572954714298,
0.00673382543027401,
0.001976621802896261,
-0.00318293459713459,
0.0010672644712030888,
-0.00040308362804353237,
-0.0009472554083913565,
0.005023205652832985,
0.000653880531899631,
0.003217478282749653,
0.0012638578191399574,
-0.008391236886382103,
0.014249099418520927,
0.004444336052983999,
0.004677906166762114,
0.020051734521985054,
-0.002849775133654475,
-0.007266485132277012,
-0.009257450699806213,
-0.013879066333174706,
-0.0034495077561587095,
0.006431125104427338,
0.005772672593593597,
-0.010666908696293831,
-0.005598732270300388,
0.0020667635835707188,
0.0735255554318428,
-0.005435132421553135,
-0.00837334617972374,
-0.004049989394843578,
0.005758280865848064,
-0.004524833057075739,
-0.004315858706831932,
0.005390942096710205,
0.0034129463601857424,
-0.003355947323143482,
0.010177863761782646,
0.010311437770724297,
0.014035786502063274,
-0.004069870337843895,
0.008732322603464127,
0.0007592051988467574,
0.0006496754940599203,
0.0033863564021885395,
-0.0067533645778894424,
-0.0111602284014225,
-0.019380418583750725,
0.007368621416389942,
-0.0022192387841641903,
-0.012924781069159508,
-0.009644242003560066,
0.00251995911821723,
-0.003993401303887367,
-0.011369031853973866,
0.0014451062306761742,
-0.00913531519472599,
0.001459178514778614,
0.013352618552744389,
0.0005357535555958748,
-0.011445913463830948,
-0.004873809404671192,
0.004131501540541649,
-0.002583002205938101,
-0.014145891182124615,
0.0034979484044015408,
0.0039644623175263405,
-0.015052607282996178,
-0.009006211534142494,
-0.011992708779871464,
0.005039689131081104,
-0.021369146183133125,
-0.005972178187221289,
-0.010783023200929165,
-0.0019920102786272764,
-0.005700550973415375,
0.012088751420378685,
-0.008976403623819351,
0.01386122964322567,
0.0005954348598606884,
0.01265701837837696,
-0.005459925625473261,
0.007689133286476135,
-0.014473415911197662,
-0.008418308570981026,
0.0027683337684720755,
-0.008114231750369072,
-0.011268828064203262,
0.004384303465485573,
0.012346259318292141,
-0.013045547530055046,
-0.013202495872974396,
-0.00458284467458725,
0.01551822479814291,
-0.017256509512662888,
0.017235897481441498,
-0.0037512043491005898,
0.016621194779872894,
0.007409142330288887,
-0.005753487814217806,
0.008338166400790215,
0.007547162473201752,
0.0003499091835692525,
-0.021758034825325012,
-0.010331760160624981,
-0.029115116223692894,
-0.011027664877474308,
-0.012583166360855103,
-0.01465984620153904,
-0.014271801337599754,
0.020136745646595955,
0.014714527875185013,
0.02452269196510315,
-0.0020157145336270332,
-0.07631738483905792,
0.016239125281572342,
0.01016179844737053,
-0.005586053244769573,
0.002158511895686388,
-0.012183849699795246,
-0.003477705642580986,
0.029816877096891403,
-0.022943219169974327,
0.0023458548821508884,
0.006381073500961065,
-0.025150679051876068,
-0.01123248040676117,
0.0011441783281043172,
0.010892273858189583,
-0.005694439634680748,
0.003033825196325779,
0.0018270568689331412,
0.015240693464875221,
0.001674066879786551,
-0.011296363547444344,
-0.022379349917173386,
-0.010194058530032635,
-0.007283441722393036,
0.0010432719718664885,
-0.08246450126171112,
0.00978152547031641,
-0.0022846125066280365,
0.0040434012189507484,
-0.012798336334526539,
-0.001977970590814948,
0.003608354367315769,
-0.007777635008096695,
0.009450393728911877,
-0.013625595718622208,
0.009729696437716484,
-0.002878311090171337,
0.002471495885401964,
-0.017545096576213837,
0.01630820706486702,
-0.002745574340224266,
0.0023642624728381634,
-0.0008966655004769564,
-0.011264340952038765,
0.023098688572645187,
0.001955293584614992,
-0.011112196370959282,
-0.007059427909553051,
-0.004516242071986198,
-0.0024296892806887627,
0.01769370771944523,
-0.01156751811504364,
0.0013213381171226501,
0.021705150604248047,
0.004775333218276501,
-0.01517401821911335,
-0.0049696736969053745,
-0.009059682488441467,
0.009378338232636452,
-0.0035714786499738693,
0.005359843838959932,
-0.009263657964766026,
-0.009797897189855576,
0.009252741932868958,
-0.01640036329627037,
0.004982739686965942,
0.008398673497140408,
-0.004386416170746088,
0.027189206331968307,
0.0013263641158118844,
0.014863349497318268,
0.0017383504891768098,
-0.0029935287311673164,
-0.0034980527125298977,
-0.029709670692682266,
0.011344026774168015,
0.0077894823625683784,
0.007453594822436571,
-0.0015680246287956834,
-0.007671643514186144,
0.015685128048062325,
0.002328776055946946,
-0.000206436263397336,
0.020195720717310905,
0.0023850391153246164,
0.0019199121743440628,
0.0050850496627390385,
-0.00875309482216835,
0.07247886061668396,
-0.024182165041565895,
0.0007387063815258443,
0.02881626971065998,
-0.0019986797124147415,
-0.0037102913483977318,
-0.0037511074915528297,
0.004236538894474506,
0.003284321166574955,
0.0022195035126060247,
0.0012027050834149122,
-0.00020879850490018725,
-0.02459338679909706,
-0.0012535532005131245,
0.027706094086170197,
0.015572444535791874,
-0.0031455629505217075,
-0.005971717648208141,
0.010489804670214653,
-0.002398520242422819,
-0.007663722150027752,
-0.014446443878114223,
-0.022528434172272682,
0.0005065537989139557,
0.015976686030626297,
-0.00017397350165992975,
-0.008977746590971947,
0.02580300346016884,
-0.0076535651460289955,
-0.0009619917254894972,
-0.01288997195661068,
0.002708940301090479,
-0.0026537843514233828,
-0.010265304706990719,
0.012449411675333977,
0.002415851689875126,
0.0008968005422502756,
-0.0057358406484127045,
-0.006842787843197584,
0.010969191789627075,
0.023496106266975403,
-0.0010059855412691832,
0.00368163688108325,
-0.004876580089330673,
-0.005706049036234617,
-0.028182562440633774,
-0.0010966809932142496,
0.014460158534348011,
-0.02071409299969673,
-0.00266672158613801,
0.007367032580077648,
0.004422040656208992,
-0.025150638073682785,
0.0031015505082905293,
-0.00710296630859375,
-0.019023919478058815,
-0.0004886388778686523,
0.005757991690188646,
0.017869072034955025,
-0.009337000548839569,
0.002590425778180361,
-0.012304091826081276,
0.007387848570942879,
-0.009059210307896137,
0.006996985990554094,
0.010009031742811203,
-0.002851156983524561,
-0.005273160524666309,
-0.018908187747001648,
0.01185593195259571,
-0.014688792638480663,
-0.003938538022339344,
-0.0037475062999874353,
-0.012364819645881653,
0.015957724303007126,
-0.0153065025806427,
-0.014889771118760109,
-0.001380853122100234,
0.000616598641499877,
0.0008589824428781867,
-0.007322288118302822,
0.007076696492731571,
0.024955395609140396,
-0.02463827282190323,
0.007022359408438206,
-0.006342930719256401,
0.02271525375545025,
-0.002310994081199169,
-0.0017860083607956767,
0.0018168516689911485,
0.0032433029264211655,
-0.003454640507698059,
-0.008782790042459965,
0.00884880218654871,
0.004616888239979744,
0.033657945692539215,
0.006295899860560894,
0.004513162188231945,
-0.009409816935658455,
-0.005556190386414528,
-0.01915813609957695,
0.0032924069091677666,
0.0009621754288673401,
0.0035290245432406664,
0.01085762307047844,
-0.0023974371142685413,
0.02092951536178589,
-0.012179674580693245,
0.023691551759839058,
-0.02144436165690422,
-0.02152710221707821,
-0.028106920421123505,
0.02374657616019249,
0.019594796001911163,
-0.0027029672637581825,
-0.004924928303807974,
0.005807774141430855,
0.01686275750398636,
-0.004024002235382795,
-0.0014526614686474204,
-0.011679694056510925,
0.0035589642357081175,
0.0018215924501419067,
0.0053556980565190315,
0.010402767919003963,
0.006382591091096401,
-0.012180275283753872,
0.006694073788821697,
0.011726373806595802,
0.004773124121129513,
0.005988411605358124,
-0.015265492722392082,
-0.008684029802680016,
0.0211775042116642,
0.008932851254940033,
-0.004105015657842159,
0.013652397319674492,
0.00530545087531209,
0.009784462861716747,
0.004632915370166302,
-0.010808853432536125,
-0.004594498313963413,
0.0006529965903609991,
0.007481332868337631,
0.006860455498099327,
0.011713898740708828,
0.0046708551235497,
0.018859192728996277,
0.00842764601111412,
-0.021084850654006004,
0.012791389599442482,
0.00853106938302517,
0.0012954999692738056,
-0.0024788849987089634,
-0.007498178165405989,
0.011524688452482224,
-0.0018379687098786235,
-0.026436245068907738,
-0.00005529180634766817,
-0.004202369600534439,
0.006193881388753653,
-0.01875888556241989,
-0.001646286342293024,
0.016397856175899506,
-0.020654579624533653,
0.01049802266061306,
-0.0024206957314163446,
-0.009671565145254135,
-0.0036684286314994097,
-0.010611042380332947,
-0.013753056526184082,
-0.007290503475815058,
-0.013618268072605133,
0.007695641368627548,
-0.0021564504131674767,
-0.010652422904968262,
-0.00470864400267601,
0.010968470945954323,
0.0036900099366903305,
0.00606622826308012,
-0.007210055366158485,
-0.0051479097455739975,
-0.0012692245654761791,
-0.004194354638457298,
-0.0066393399611115456,
0.01188009325414896,
0.003896257607266307,
-0.0016732997028157115,
0.0010192793561145663,
0.010416068136692047,
0.002241445006802678,
-0.029478996992111206,
-0.014187474735081196,
0.008339478634297848,
0.01792241260409355,
0.0019707779865711927,
-0.012033185921609402,
0.015464335680007935,
0.0013735159300267696,
0.002027238253504038,
-0.0090760737657547,
-0.010695639997720718
] | [
0.3147818446159363,
0.01655592955648899,
0.033596571534872055,
-0.08181925117969513,
0.162841796875,
0.5701302289962769,
-0.0956348329782486,
-0.5070064067840576,
-0.1637038290500641,
-0.06106279045343399,
0.13880209624767303,
0.4056525230407715,
0.5044185519218445,
0.19702047109603882,
-0.7323864698410034,
0.10142398625612259,
0.6311675906181335,
0.6244120001792908,
-0.01310444064438343,
-0.4071632921695709,
-0.3997098505496979,
-0.40030717849731445,
0.5300718545913696,
0.18066486716270447,
0.21283912658691406,
0.25103890895843506,
0.6409603953361511,
0.011558331549167633,
0.2721998393535614,
-0.17632389068603516,
-0.253363698720932,
-0.020566340535879135,
0.17498178780078888,
0.020105084404349327,
0.33358508348464966,
-0.04647813364863396,
0.35607078671455383,
0.03600722551345825,
0.0597139410674572,
-0.4688500463962555,
-0.3363837003707886,
0.18130023777484894,
-0.26975637674331665,
0.6542661786079407,
0.1088859811425209,
-0.5483213067054749,
-1.6784039735794067,
-0.21755680441856384,
-0.3403897285461426,
-0.4081050455570221,
-0.16021005809307098,
-0.021182628348469734,
0.3221425712108612,
0.12398193031549454,
0.03872319310903549,
0.14356496930122375,
-0.31580957770347595,
-0.0398809090256691,
-0.0070439716801047325,
-0.332280695438385,
0.18135876953601837,
-0.07563689351081848,
0.36483442783355713,
0.05694935470819473,
0.25438594818115234,
-0.08167488873004913,
0.10739114880561829,
-0.2124953716993332,
-0.09856591373682022,
-0.133708655834198,
-0.6595357060432434,
-0.4031499922275543,
-0.32412877678871155,
0.1845189332962036,
-0.023771187290549278,
0.8193519115447998,
-0.03609078750014305,
-0.4055631756782532,
0.6818541884422302,
-0.25366532802581787,
0.014903672970831394,
0.32825449109077454,
-0.16295860707759857,
-0.03300586715340614,
0.5307678580284119,
0.09986112266778946,
0.12297149747610092,
0.7217949032783508,
0.24541924893856049,
0.6614317893981934,
0.12732760608196259,
0.13722823560237885,
0.367036372423172,
0.45634925365448,
0.24847805500030518,
0.05803658813238144,
0.462985634803772,
0.036622289568185806,
0.44882556796073914,
0.08263625204563141,
0.0630331039428711,
-0.004723172634840012,
0.09678780287504196,
-0.3139815330505371,
-0.30493733286857605,
-0.641301691532135,
0.0020404912065714598,
-0.32747527956962585,
0.14205552637577057,
0.24900051951408386,
-0.2883746027946472,
0.774120032787323,
-0.0834202989935875,
-0.10064616054296494,
0.09235091507434845,
0.15371686220169067,
0.28089386224746704,
-0.2154921591281891,
-0.5280606150627136,
0.14186951518058777,
-0.9454401135444641,
0.19125106930732727,
0.0822504386305809,
-0.049903254956007004,
0.360848993062973,
0.25062549114227295,
0.43135425448417664,
0.72691410779953,
-0.43378394842147827,
0.20634537935256958,
-0.10384519398212433,
-0.06212407350540161,
0.10596337169408798,
-0.13063500821590424,
-0.33508139848709106,
-0.1493295282125473,
0.13210409879684448,
0.4424414038658142,
0.6469072699546814,
0.06445319205522537,
-0.17704036831855774,
-0.18121439218521118,
-0.02546704187989235,
-0.17868059873580933,
0.3210466206073761,
-0.6343084573745728,
0.45046964287757874,
-0.01209971122443676,
-0.2175658494234085,
0.2703401744365692,
0.23786155879497528,
-0.18140794336795807,
-0.1507159024477005,
-0.30278295278549194,
0.03900877386331558,
0.0735374316573143,
-0.05951091647148132,
-0.04057565703988075,
-0.2568543255329132,
-0.21527236700057983,
0.2109614461660385,
0.13473272323608398,
-0.31171417236328125,
-0.09319543838500977,
0.018416104838252068,
-0.2822948098182678,
0.6599283218383789,
0.27585700154304504,
0.39934372901916504,
0.20367871224880219,
-0.3862454295158386,
0.27626940608024597,
-0.4621938467025757,
-0.24183526635169983,
-0.3589375913143158,
0.35188761353492737,
0.5273790955543518,
0.518853485584259,
-0.19993901252746582,
0.06832630187273026,
-0.3655087947845459,
0.3207256495952606,
0.024645760655403137,
-0.32620421051979065,
0.39765307307243347,
-0.022220436483621597,
0.18381913006305695,
-0.08462514728307724,
-0.4326557219028473,
-0.34894847869873047,
-0.2747127413749695,
-0.5314294099807739,
0.5594958662986755,
-0.027616309002041817,
0.7121334075927734,
-0.19089104235172272,
-0.3192870318889618,
1.167581558227539,
-0.4342094361782074,
-0.26826193928718567,
0.26740753650665283,
0.1670720875263214,
0.12082668393850327,
-0.05350913107395172,
-0.9310805201530457,
-0.06441973894834518,
-0.04980548843741417,
0.16718824207782745,
-0.4101860523223877,
0.06298527121543884,
0.19918029010295868,
0.033460743725299835,
-0.23307988047599792,
-0.13139210641384125,
-0.07607879489660263,
0.04263242706656456,
0.09717816859483719,
0.8266657590866089,
-0.09136570990085602,
0.31438302993774414,
0.7097838521003723,
0.0016751078655943274,
0.32917630672454834,
0.05348946526646614,
0.11436010152101517,
0.1764315366744995,
0.41714176535606384,
-0.030046042054891586,
0.4502650201320648,
-0.36344391107559204,
0.11855516582727432,
0.08139767497777939,
0.5308350920677185,
-0.11924657970666885,
0.07899071276187897,
0.1062885969877243,
-0.21806249022483826,
-0.2615109384059906,
0.06824732571840286,
-0.29048702120780945,
0.3973236382007599,
0.16846835613250732,
-0.31577128171920776,
0.556636393070221,
0.08077964931726456,
-0.0796482264995575,
-0.3810129761695862,
0.36417898535728455,
-0.8695390224456787,
-0.20292215049266815,
0.2650296986103058,
0.6803262233734131,
0.6672950387001038,
0.26712721586227417,
-0.10514675825834274,
-0.23788730800151825,
-0.7244371175765991,
-0.4057333767414093,
1.0171946287155151,
0.057384513318538666,
0.5087165832519531,
0.2205532044172287,
0.4719310700893402,
0.11357531696557999,
-0.23353274166584015,
0.0577440969645977,
-0.7896625399589539,
-0.7739872336387634,
-0.1283213347196579,
0.18382959067821503,
0.5282366871833801,
0.2364829182624817,
-1.055586814880371,
0.186589315533638,
0.11088397353887558,
-0.5211168527603149,
0.5661596655845642,
0.27176758646965027,
-0.3786458373069763,
-0.6439451575279236,
0.03419102355837822,
1.0837068557739258,
0.8719276785850525,
-0.20404541492462158,
-0.07515273988246918,
-0.5632027387619019,
0.4036036729812622,
-0.4593833386898041,
-0.30540817975997925,
-0.2467929720878601,
-0.07733402401208878,
0.13624553382396698,
-0.3674558103084564,
-0.5355223417282104,
0.7553489208221436,
1.0758676528930664,
-0.1893579214811325,
0.6360929012298584,
0.611608624458313,
0.16529729962348938,
0.38491174578666687,
0.10263597965240479,
0.1299934983253479,
0.19528867304325104,
-0.04944070801138878,
-0.30321425199508667,
-0.01986771449446678,
-0.058504387736320496,
-6.084214687347412,
0.021452397108078003,
-0.23327475786209106,
-0.26185259222984314,
-0.1266176551580429,
-0.24372601509094238,
0.60077965259552,
-0.4267863929271698,
-0.29294562339782715,
0.2873803973197937,
0.40710821747779846,
0.2066001147031784,
0.1740676760673523,
0.06353843957185745,
0.27970442175865173,
0.3969663381576538,
0.45693472027778625,
0.11002136766910553,
-0.13044647872447968,
0.16573664546012878,
0.7374051213264465,
-0.2835237979888916,
-0.10934140533208847,
0.25691068172454834,
0.26537469029426575,
0.2251247614622116,
-0.11506448686122894,
0.002515224739909172,
-0.40219005942344666,
0.11359036713838577,
-0.03195725381374359,
-0.2795065641403198,
0.1501048505306244,
-0.24541804194450378,
0.4980548918247223,
0.36514779925346375,
0.16365446150302887,
0.09919700771570206,
0.7801811695098877,
-0.07893021404743195,
0.17623403668403625,
0.41856619715690613,
0.1437625288963318,
-0.1218375563621521,
0.5223847031593323,
-0.06825633347034454,
-0.014037341810762882,
-0.37715309858322144,
-0.3911704123020172,
0.7429025173187256,
0.053891364485025406,
-0.029540399089455605,
-0.09824563562870026,
0.05652271956205368,
-0.37476569414138794,
0.15450341999530792,
-0.396920382976532,
0.19513559341430664,
-0.6155501008033752,
0.2687106430530548,
-0.4333263039588928,
-0.08335471898317337,
0.44231435656547546,
-0.7169013023376465,
-0.3778650462627411,
-0.030813124030828476,
-0.9356165528297424,
-0.34486740827560425,
-0.24285387992858887,
0.18569324910640717,
-0.5656058192253113,
0.11259081959724426,
0.5696799755096436,
-0.9074407815933228,
0.4000486433506012,
-0.5845319628715515,
-0.03980650007724762,
0.2050083577632904,
-0.17843323945999146,
-0.4987432658672333,
0.28513863682746887,
-0.5238614082336426,
0.13900251686573029,
0.571134626865387,
-0.02627924457192421,
-0.42202091217041016,
-0.029387135058641434,
-0.13204987347126007,
-0.8792222142219543,
0.11293446272611618,
0.5035160183906555,
-0.06233888119459152,
-0.33599239587783813,
0.2690199315547943,
0.42030155658721924,
0.44341522455215454,
0.005414312705397606,
-0.0648936778306961,
0.6828802824020386,
-0.4095129668712616,
0.10907693207263947,
-0.032765619456768036,
-0.0734102800488472,
-0.8278718590736389,
-0.2181345820426941,
-0.5345006585121155,
-0.28474748134613037,
0.12180101126432419,
0.8488038182258606,
-1.2027567625045776,
-0.0854601338505745,
0.19654713571071625,
-0.6803776025772095,
-0.848486065864563,
0.2944576144218445,
-0.11164003610610962,
-0.39762231707572937,
-0.022139020264148712,
0.5464474558830261,
0.0880318209528923,
0.12772956490516663,
0.036209139972925186,
-0.16680015623569489,
-0.689008891582489,
0.020499831065535545,
-0.46773532032966614,
0.4023761749267578,
0.2883318364620209,
-0.7723845839500427,
0.35076624155044556,
0.04439200833439827,
0.4259752929210663,
-0.0787372961640358,
-0.16894760727882385,
-0.46588924527168274,
0.11086857318878174,
-0.11620042473077774,
0.2921735644340515,
-0.5356928110122681,
-0.3558928668498993,
0.03200623020529747,
0.31521353125572205,
-0.34199944138526917,
-0.3663713037967682,
-0.14677950739860535,
0.18538221716880798,
-0.2503446340560913,
-0.010212959721684456,
-0.2985706627368927,
-0.0882883369922638,
0.005492424126714468,
-0.18942828476428986,
0.4490179717540741,
-0.004530070349574089,
-0.19471782445907593,
-0.1120234876871109,
0.7511643171310425,
0.7883504033088684,
-0.2671254277229309,
-0.613264262676239,
-0.07811234891414642,
-0.32028019428253174,
-0.9977540373802185,
-0.16663889586925507,
-0.03103533759713173,
0.34537866711616516,
-0.19780166447162628,
-0.43275243043899536,
0.06844427436590195,
0.43866661190986633,
0.4735581576824188,
-0.4390089213848114,
-0.7559617161750793,
-0.17972633242607117,
0.09707283228635788,
0.05511244013905525,
-0.038096290081739426,
-0.06969157606363297,
-0.34093740582466125,
-0.1813122183084488,
-0.07057279348373413,
-0.9668687582015991,
-0.02983783558011055,
-0.07428531348705292,
0.6197064518928528,
0.4262489080429077,
-0.42926618456840515,
-0.3133370280265808,
-0.9295518398284912,
0.13077424466609955,
0.2819698452949524,
-0.32008126378059387,
0.5952773690223694,
-0.1581406593322754,
-0.15911366045475006,
0.1929999440908432,
0.14034278690814972,
0.3053230047225952,
-0.1654033213853836,
0.16355256736278534,
-0.21350066363811493,
0.2851001024246216,
-0.5633479952812195,
0.3091093897819519,
0.25726592540740967,
-0.6301453113555908,
-0.05127411708235741,
-0.2079494446516037,
-0.47147777676582336,
0.34574905037879944,
-0.25015753507614136,
0.16269662976264954,
0.051953721791505814,
0.5935733914375305,
-0.143581360578537,
0.2592722773551941,
-0.07652431726455688,
-0.23783870041370392,
-0.24156157672405243,
-0.024033624678850174,
0.5333568453788757,
-0.30795422196388245,
-0.6916873455047607,
-0.06023387238383293,
-0.06030774116516113,
0.18057885766029358,
0.35913965106010437,
-0.7492067217826843,
0.3556678593158722,
-0.0329599566757679,
-0.3518509864807129,
0.08480524271726608,
0.2137150764465332,
-0.049191538244485855,
-0.3620886206626892,
-0.1400061696767807,
-0.04534382000565529,
0.24221663177013397,
-0.1782522201538086,
0.5430881381034851,
0.11410386860370636,
0.5447407364845276,
-0.0006799802067689598,
-0.2718919515609741,
-0.1776287704706192,
0.47903743386268616,
-0.136498361825943,
-0.6500725746154785,
-0.5152108073234558,
-0.1241019070148468,
-0.04485373571515083,
-0.31244876980781555,
0.06114150956273079,
-0.11504969745874405,
0.17219598591327667,
-0.30637669563293457,
-0.25486674904823303,
-0.5485792756080627,
0.037151604890823364,
0.02014271542429924,
0.3229723572731018,
-0.09440203756093979,
-0.6723080277442932,
-0.01585160382091999,
0.6290018558502197,
0.5428791642189026,
0.033250488340854645,
-0.06552140414714813,
0.3165372610092163,
-0.3170979917049408,
-0.10134988278150558,
-0.15691664814949036,
0.06340301781892776,
0.2477189302444458,
0.24067449569702148,
0.10948821157217026,
-0.3940492272377014,
-0.2315487414598465,
0.29590246081352234,
0.26820725202560425,
-0.10707070678472519,
-0.28730955719947815,
-0.14458677172660828,
-0.395503431558609,
0.26891759037971497,
-0.03850921243429184,
-0.0589761883020401,
0.062042780220508575,
-0.2667003870010376,
0.312014102935791,
-0.09311685711145401,
-0.07394082099199295,
-0.6594451665878296,
-0.6112877726554871,
-0.13031500577926636,
0.5456390976905823,
0.18591861426830292,
0.19583365321159363,
-0.1957729011774063,
-0.5189931988716125,
-0.40762776136398315,
0.4027325510978699,
0.12431896477937698,
-0.10845603048801422,
0.11195726692676544,
0.13454096019268036,
-0.019478704780340195,
-0.1630731076002121,
-0.24638068675994873,
0.6636120080947876,
-0.2183111310005188,
-0.019183505326509476,
0.4453562796115875,
0.9046164155006409,
-0.3936426639556885,
-0.2682148516178131,
-0.030963942408561707,
0.13962683081626892,
0.3507833480834961,
0.25568050146102905,
-0.266072154045105,
0.5238358378410339,
0.5152139067649841,
0.04290124401450157,
-0.6396627426147461,
0.12709389626979828,
0.022647948935627937,
0.24606147408485413,
-0.19714319705963135,
0.053487248718738556,
0.264149010181427,
0.911687433719635,
-0.06055597588419914,
0.5399957895278931,
0.35768723487854004,
-0.2713863253593445,
0.1802528202533722,
-0.3221918046474457,
-0.2642503082752228,
0.6191325187683105,
0.6934440732002258,
0.2113347202539444,
0.13832217454910278,
0.16629080474376678,
-0.15402190387248993,
0.15365521609783173,
-0.31908875703811646,
-0.002153147244825959,
0.10309265553951263,
-0.048147331923246384,
0.1850459724664688,
-0.11448252946138382,
-0.3875584602355957,
-0.3480725884437561,
-0.12829764187335968,
0.16123077273368835,
0.6579458713531494,
-0.8748735189437866,
-0.36727267503738403,
0.027338782325387,
-0.41583946347236633,
0.3456280529499054,
-0.20271827280521393,
-0.24134181439876556,
0.36076489090919495,
0.12028981000185013,
0.48235058784484863,
0.10350919514894485,
0.06365589797496796,
0.07362322509288788,
0.04277333989739418,
0.32004761695861816,
-0.48434463143348694,
-0.2805140018463135,
0.5472248196601868,
0.2383424937725067,
0.033378660678863525,
0.31095752120018005,
-0.15281032025814056,
0.27820098400115967,
0.3930826783180237,
-0.24276526272296906,
-0.26822859048843384,
-0.21936975419521332,
-0.4095842242240906,
-0.0414082333445549,
0.3336726129055023,
0.25332123041152954,
0.4177270829677582,
-0.22930486500263214,
0.24966470897197723,
-0.8251178860664368,
-0.16304008662700653,
0.4108455777168274,
-0.33835747838020325,
0.3620108664035797,
0.08526177704334259,
0.5850644707679749,
0.49981606006622314,
0.18074500560760498,
-0.37220507860183716,
-0.1971098780632019,
-0.43874722719192505,
0.4541572332382202,
-0.25346291065216064,
0.36835694313049316,
-0.3616344928741455,
-0.11934713274240494,
-0.45370981097221375,
-0.12522722780704498,
0.4026391804218292,
-0.025914378464221954,
-0.20982979238033295,
-0.12766338884830475,
-0.07217054814100266,
0.3458862006664276,
0.24274758994579315,
-0.49251994490623474,
-0.29485654830932617,
-0.40648573637008667,
-0.3858530819416046,
-0.1298917531967163,
0.27633237838745117,
-0.13038675487041473,
0.021314632147550583,
-0.016242483630776405,
0.14587508141994476,
-0.16398948431015015,
-0.48455342650413513,
-0.04976052790880203,
-0.6366620063781738,
-0.1702372282743454,
-0.5572949647903442,
0.476976603269577,
-0.46432846784591675,
0.5749214291572571,
0.36668911576271057,
-0.10264243185520172,
0.5450263619422913,
-0.2377079725265503,
-0.1261712908744812,
-0.4679279625415802,
0.3307863175868988,
0.39936134219169617,
0.2925400137901306,
0.27701303362846375,
-0.2790113091468811,
-0.3018176853656769,
0.1502486616373062,
0.09752396494150162,
-0.36075112223625183,
0.16472771763801575,
-0.3238318860530853,
-0.36575570702552795,
-0.27986714243888855,
0.1013299897313118,
-0.07827161252498627,
-0.7328904271125793,
0.0011328750988468528,
-0.2242937833070755
] |
Human beings, make errors Healthcare Services is a complex industry prone to accidents. The IOM Report [1] points out that some systems are more prone to accidents than others. When a system fails there are often multiple faults. In healthcare,human errors are the greatest contributors to accidents,however when human error is to blame it often depends upon failures within the system. These failures exists in the system before the error occurs, the same as with latent errors which are difficult to identify since they may be hidden in computers or within the various managerial layers. Most of the errors can be prevented by designing systems that make it hard for people to do the wrong thing and easy for people to do the right thing. In healthcare, this means designing processes that are able to ensure that patients are safe from accidental injury. As healthcare and the system that delivers it become more complex, the opportunities for errors abound. The IOM report “To Err is Human” proposes an approach for reducing medical errors and improving patient safety. The environment within which this occurs has a critical influence on quality. This influence may contain two dimensions; the first consists of the domain of quality which includes the practice that is consistent with current medical knowledge. The second dimension consists of forces in the external environment that can drive quality improvement in the delivery system. Although the risk of dying as a result of a medical error, far surpasses the risk of dying in an airline accident, public attention has been more focused on improving safety in the airline industry than in healthcare systems. Because of the absence of standardized nomenclature, it is important to define what an error is and what is an adverse event, the IOM Report defines them in the following way: “An error is the failure of a planned action to be completed as intended or the use of a wrong plan to achieve an aim. ” An adverse event is an injury caused by medical management rather than the underlying condition of the patient. An adverse event attributable to error is a “preventable adverse event”. | [
-0.012287833727896214,
0.02039428800344467,
-0.012414231896400452,
0.021098550409078598,
0.004934782162308693,
0.001354617066681385,
0.008296416141092777,
0.006564962677657604,
-0.006674794014543295,
-0.01792144402861595,
-0.008161736652255058,
0.007467441726475954,
0.01664445549249649,
0.03225822001695633,
-0.014182820916175842,
-0.007750227581709623,
0.002454330213367939,
-0.001932122278958559,
0.001122613437473774,
-0.028498010709881783,
0.017972495406866074,
0.009170707315206528,
0.008561628870666027,
-0.01832314394414425,
-0.000043130479753017426,
0.001332759391516447,
0.016830183565616608,
0.015819868072867393,
0.013736683875322342,
0.02927369438111782,
-0.00899958610534668,
0.02206931822001934,
0.016384359449148178,
0.007967069745063782,
0.015376016497612,
0.0006358913378790021,
0.005127388052642345,
0.0008676154538989067,
0.008593782782554626,
-0.00439272727817297,
0.03157222270965576,
0.0016761105507612228,
0.00039298535557463765,
-0.005296989344060421,
-0.013217499479651451,
0.011177973821759224,
0.0030846577137708664,
0.04287094622850418,
0.010287459939718246,
0.011998254805803299,
-0.003613584442064166,
-0.0012306016869843006,
0.002800093963742256,
0.002480023540556431,
-0.005324428901076317,
0.0019698673859238625,
0.0179908350110054,
0.009649747051298618,
-0.01659521460533142,
0.024552403017878532,
0.005401396658271551,
-0.005561964586377144,
-0.005306129809468985,
0.002020864048972726,
-0.009998871944844723,
-0.06753426790237427,
0.013692116364836693,
0.006511061452329159,
0.005515239201486111,
0.03864050656557083,
0.014063756912946701,
0.0047109080478549,
-0.018972499296069145,
0.015719890594482422,
-0.010181228630244732,
0.0036771500017493963,
0.0034683046396821737,
-0.023612109944224358,
0.0026044431142508984,
0.022014953196048737,
-0.03579811006784439,
-0.018329977989196777,
0.009950551204383373,
0.017758658155798912,
0.0073994663543999195,
0.02474062889814377,
0.0012098298175260425,
-0.008581535890698433,
-0.0024159522727131844,
0.004454782232642174,
-0.004781536757946014,
0.04127304255962372,
-0.016613366082310677,
0.010870096273720264,
-0.011734837666153908,
-0.01014716923236847,
-0.018961630761623383,
0.02481134608387947,
-0.000737418420612812,
-0.0018401718698441982,
-0.005987442098557949,
0.015318373218178749,
0.021587451919913292,
0.013076155446469784,
0.023567616939544678,
0.0036881528794765472,
-0.01666053757071495,
-0.0229691993445158,
0.004275635350495577,
0.013285776600241661,
-0.004377876408398151,
-0.0013257702812552452,
0.01904485560953617,
0.015954697504639626,
0.02047973871231079,
0.012000462971627712,
0.0098709836602211,
0.00749683752655983,
0.002422807738184929,
0.020507168024778366,
0.012515868991613388,
-0.013347774744033813,
-0.0000832853838801384,
0.002006593393161893,
0.0025109504349529743,
0.02157086692750454,
-0.005255484953522682,
-0.016427360475063324,
-0.0032988046295940876,
-0.0003243205137550831,
-0.014110377989709377,
-0.0005016716895624995,
-0.050272487103939056,
0.008859021589159966,
0.00031433370895683765,
-0.005700058303773403,
-0.016749097034335136,
0.02646717056632042,
-0.00816956628113985,
0.016027605161070824,
0.022883467376232147,
0.005000480450689793,
-0.0010305524338036776,
0.020334448665380478,
0.024389874190092087,
0.0009683694806881249,
-0.017375094816088676,
0.022433318197727203,
0.03635118156671524,
-0.027963723987340927,
-0.01472096610814333,
-0.014550676569342613,
-0.0032876767218112946,
-0.008894572965800762,
-0.038724783807992935,
0.0046659670770168304,
0.008101314306259155,
-0.007934863679111004,
-0.0226646289229393,
-0.0015494161052629352,
-0.007004169747233391,
-0.019579842686653137,
0.009224717505276203,
0.00719761848449707,
0.006898300722241402,
0.026855122298002243,
0.010708054527640343,
-0.007615623530000448,
-0.005249268840998411,
0.0006398734403774142,
-0.012869590893387794,
-0.022959038615226746,
-0.0013167979195713997,
0.007543399930000305,
-0.001991803990676999,
-0.011888385750353336,
0.025331711396574974,
0.00829448364675045,
-0.012754222378134727,
0.06743124127388,
0.00075682089664042,
0.000689254142343998,
0.006351236719638109,
0.005606298800557852,
0.021568581461906433,
-0.004071083851158619,
0.002172582782804966,
-0.008744286373257637,
0.002205598633736372,
0.017694471403956413,
-0.006772302556782961,
-0.0278029702603817,
0.000402890145778656,
-0.004624322056770325,
-0.0013631847687065601,
0.003472615499049425,
0.01622544229030609,
-0.0037755302619189024,
0.01344537828117609,
0.00101490318775177,
0.002123395912349224,
0.0080795269459486,
0.01445609237998724,
-0.00600831676274538,
0.021070951595902443,
0.019384706392884254,
0.012768018990755081,
0.0028489050455391407,
0.009975875727832317,
0.037240028381347656,
-0.011902736499905586,
0.014962466433644295,
0.015345647931098938,
-0.009909681044518948,
0.000799897126853466,
0.01415466982871294,
0.01506069302558899,
0.021645547822117805,
-0.0012175706215202808,
-0.011936573311686516,
0.0013555421028286219,
-0.01371670886874199,
0.005657142028212547,
-0.0033890039194375277,
-0.018286917358636856,
-0.011753162369132042,
0.011986927129328251,
0.014159118756651878,
0.0022183326072990894,
0.012587849982082844,
-0.010120369493961334,
-0.028368789702653885,
-0.004493948072195053,
0.0013279016129672527,
0.03877667337656021,
-0.006275131832808256,
0.008874067105352879,
-0.027850713580846786,
0.019550058990716934,
-0.013313937932252884,
0.018380187451839447,
0.008428223431110382,
-0.000018912367522716522,
-0.0021270555444061756,
-0.009296483360230923,
-0.02236390858888626,
-0.016522372141480446,
0.0031649721786379814,
-0.004703151062130928,
0.010925599373877048,
0.0024832189083099365,
-0.015186561271548271,
0.013546280562877655,
-0.0021316122729331255,
0.015558414161205292,
0.002722769510000944,
-0.010554168373346329,
-0.009388841688632965,
0.023709440603852272,
0.000622080871835351,
-0.004419025499373674,
0.006831392180174589,
0.039453063160181046,
-0.009826445952057838,
0.02217470481991768,
-0.018418191000819206,
-0.006740352604538202,
0.008822627365589142,
0.006936114281415939,
-0.014724119566380978,
0.002324707806110382,
-0.007540256716310978,
-0.0016413538251072168,
-0.08157694339752197,
-0.021356577053666115,
0.019144874066114426,
0.010195563547313213,
0.008040335029363632,
0.019997235387563705,
-0.01781543716788292,
-0.0020893686451017857,
-0.02455952763557434,
0.007651442661881447,
0.010445762425661087,
-0.000999797135591507,
-0.009156417101621628,
-0.007030576467514038,
0.0034075845032930374,
-0.006018445361405611,
-0.0025953869335353374,
-0.016892561689019203,
-0.007869002409279346,
0.006007625255733728,
0.01958080753684044,
-0.0504465289413929,
0.014689311385154724,
-0.010116194374859333,
0.022106489166617393,
0.010026099160313606,
0.008930952288210392,
0.0026797503232955933,
-0.0013761171139776707,
0.012301337905228138,
0.019063115119934082,
-0.008782058954238892,
0.006399406120181084,
-0.0034875678829848766,
0.0002761627547442913,
-0.023868292570114136,
-0.005270418711006641,
0.003988775424659252,
0.008311349898576736,
-0.014843839220702648,
-0.0010371729731559753,
0.023524736985564232,
0.018969470635056496,
0.008768356405198574,
0.01117122732102871,
0.01293026190251112,
0.012783864513039589,
0.005012890323996544,
-0.004115863237529993,
0.017708631232380867,
0.01531995739787817,
-0.021571092307567596,
0.01976160891354084,
0.00629734480753541,
-0.0015871523646637797,
0.0030752522870898247,
-0.0024750095326453447,
-0.014695818535983562,
-0.00839771144092083,
-0.007495720870792866,
-0.006458664312958717,
0.017829865217208862,
-0.01682775840163231,
0.011597616598010063,
-0.016469206660985947,
0.005107774864882231,
0.0065247248858213425,
-0.012488480657339096,
-0.0035847474355250597,
0.005812015384435654,
0.02592477761209011,
0.017791057005524635,
0.02999650500714779,
-0.0011097644455730915,
-0.006559375673532486,
-0.0012299949303269386,
-0.013357037678360939,
0.00047993496991693974,
-0.013638565316796303,
0.0426689013838768,
-0.03282184526324272,
-0.002054092474281788,
0.011164785362780094,
-0.011481315828859806,
-0.007806187029927969,
-0.013132053427398205,
0.008585881441831589,
-0.023238062858581543,
0.014565443620085716,
-0.006084900349378586,
0.028056928887963295,
0.00036443863064050674,
-0.012613276019692421,
0.008149448782205582,
0.0017310944385826588,
-0.030691668391227722,
0.01931387558579445,
-0.010190642438828945,
-0.012808182276785374,
0.007482294924557209,
-0.03277239203453064,
0.0014583375304937363,
-0.010605854913592339,
-0.013898419216275215,
0.010471039451658726,
-0.0027763135731220245,
0.0005170884542167187,
-0.00015898910351097584,
-0.005986982025206089,
-0.011170169338583946,
0.005054498091340065,
-0.014706604182720184,
-0.007802103646099567,
-0.03948478400707245,
0.0014586126198992133,
-0.00009401340503245592,
-0.017920494079589844,
-0.011818894185125828,
0.07257790863513947,
-0.013430536724627018,
0.016513269394636154,
0.0094149149954319,
0.029115743935108185,
-0.02411457896232605,
-0.003763770218938589,
0.031167376786470413,
0.0013119089417159557,
-0.03231393173336983,
0.011613268405199051,
0.004807644989341497,
0.004230079241096973,
-0.024312421679496765,
-0.011894948780536652,
-0.01676107384264469,
-0.025287561118602753,
-0.029078802093863487,
-0.04530075937509537,
-0.001350213075056672,
0.000745608820579946,
0.026911180466413498,
-0.016348395496606827,
0.030314994975924492,
-0.006346811540424824,
-0.03447730466723442,
-0.011071018874645233,
-0.015109874308109283,
0.01095515675842762,
-0.001648654812015593,
0.001002483069896698,
0.031409841030836105,
-0.0023916438221931458,
-0.010559169575572014,
-0.0026210532523691654,
-0.010497494600713253,
0.012267074547708035,
-0.005676357075572014,
0.008372152224183083,
-0.0036670644767582417,
0.010659119114279747,
-0.003793114796280861,
-0.004461049567908049,
0.0073475465178489685,
-0.025422044098377228,
0.01239581499248743,
0.012845736928284168,
-0.013006526976823807,
0.022972090169787407,
-0.005626909900456667,
0.0011285108048468828,
0.011076211929321289,
0.006235908716917038,
-0.006291079800575972,
0.020643416792154312,
0.014188216999173164,
-0.012415782548487186,
0.005140159744769335,
0.014990553259849548,
-0.00527008343487978,
0.02542858012020588,
-0.0014958912506699562,
0.030852071940898895,
-0.01895197667181492,
-0.0019360794685781002,
0.0046569788828492165,
-0.00952131673693657,
-0.013362351804971695,
-0.0020980462431907654,
0.0077250925824046135,
0.0002501423005014658,
0.02554023638367653,
0.011560320854187012,
-0.0011781230568885803,
-0.010858745314180851,
-0.010711531154811382,
-0.022791124880313873,
-0.02215648628771305,
0.007605515420436859,
-0.00399512704461813,
-0.012258464470505714,
-0.010980239138007164,
0.00955342035740614,
-0.0004683096194639802,
-0.011710229329764843,
0.019766028970479965,
-0.013790106400847435,
-0.07454781234264374,
-0.010809376835823059,
0.023302026093006134,
-0.008548494428396225,
-0.03722070902585983,
-0.021986979991197586,
-0.0021103147882968187,
-0.02842363528907299,
0.010709733702242374,
-0.01582973077893257,
-0.033825308084487915,
-0.004340847954154015,
-0.004988671280443668,
0.002327529713511467,
0.013342726044356823,
0.0016578480135649443,
0.01548607274889946,
-0.015011858195066452,
-0.0127564063295722,
0.014198734425008297,
-0.00690310075879097,
-0.02343146875500679,
-0.0016644607530906796,
0.0043474361300468445,
0.0010502412915229797,
-0.08153071999549866,
0.00824386440217495,
0.0010594029445201159,
-0.01769598387181759,
-0.004324391018599272,
-0.00841641053557396,
0.013447828590869904,
-0.012737688608467579,
-0.03300964832305908,
-0.010681712068617344,
-0.046079374849796295,
-0.00303280190564692,
0.022316575050354004,
-0.008959739468991756,
0.02535313181579113,
-0.0074426219798624516,
0.005918276496231556,
-0.0029018442146480083,
-0.014185464009642601,
0.01696242019534111,
-0.04532995820045471,
0.006747253704816103,
-0.0032138433307409286,
0.007683602161705494,
-0.021288540214300156,
-0.03832888603210449,
-0.004244857467710972,
0.005128141958266497,
0.0039847297593951225,
0.004833363927900791,
-0.002659933641552925,
0.01208425685763359,
0.007804469205439091,
-0.003125641494989395,
0.0023239324800670147,
-0.0034626214765012264,
0.04728509485721588,
-0.03185300529003143,
0.025330929085612297,
-0.014382530003786087,
-0.005755954422056675,
-0.01124599575996399,
0.016862154006958008,
0.008432900533080101,
0.007576931267976761,
-0.007091966457664967,
0.0061954837292432785,
-0.009660325944423676,
0.022615456953644753,
0.01632128469645977,
-0.0010534386383369565,
-0.014804105274379253,
0.0064354571513831615,
-0.0029421746730804443,
0.002801216673105955,
-0.005449420306831598,
-0.010556663386523724,
0.0018682742957025766,
0.014972316101193428,
0.005514431744813919,
0.005564643070101738,
-0.012716403231024742,
-0.013405201956629753,
0.07246735692024231,
-0.018619023263454437,
0.008478008210659027,
0.003317468799650669,
-0.012868132442235947,
-0.006020278204232454,
0.005754770711064339,
-0.01641588658094406,
-0.016198305413126945,
-0.001743376487866044,
-0.01597689837217331,
-0.024144107475876808,
0.008666948415338993,
-0.001621696283109486,
0.013457244262099266,
-0.027855321764945984,
-0.01905903033912182,
-0.007963381707668304,
0.005678246263414621,
-0.02747122198343277,
0.015140901319682598,
0.00987462978810072,
-0.003779637161642313,
-0.011723427101969719,
0.018476761877536774,
0.013047072105109692,
-0.004819459281861782,
0.006925735156983137,
0.0012601199559867382,
-0.009727876633405685,
-0.005671701394021511,
0.01453769113868475,
0.00037892640102654696,
0.016618594527244568,
0.0018108709482476115,
-0.0074251205660402775,
-0.005315721500664949,
-0.004139005672186613,
-0.0032752102706581354,
0.020569881424307823,
0.04897722601890564,
-0.0008179307915270329,
-0.002692348090931773,
-0.03868566453456879,
-0.0028862657491117716,
0.003412388265132904,
0.009479055181145668,
-0.020443161949515343,
-0.0012621043715626001,
0.02035238780081272,
-0.007325173355638981,
0.007504384499043226,
0.008757099509239197,
-0.018604107201099396,
0.002463636454194784,
-0.01364886574447155,
0.000028732698410749435,
0.012339156121015549,
0.015762489289045334,
0.0027489520143717527,
-0.015606733970344067,
-0.006637774407863617,
-0.010550739243626595,
-0.007598960306495428,
0.0027879681438207626,
-0.014757487922906876,
-0.009912054985761642,
-0.008414901793003082,
0.026284974068403244,
0.002766616875305772,
0.00582211185246706,
0.0057239956222474575,
0.0025458508171141148,
0.013741256669163704,
0.005304805934429169,
0.013180598616600037,
-0.012456171214580536,
-0.003287079744040966,
0.009017422795295715,
0.011850581504404545,
0.007143049500882626,
-0.013014893047511578,
0.054179444909095764,
-0.028998762369155884,
-0.015710677951574326,
0.0037589878775179386,
0.011531256139278412,
-0.0004516418557614088,
-0.013437188230454922,
0.013260847888886929,
-0.016269629821181297,
-0.004606651142239571,
-0.007843829691410065,
-0.004255405627191067,
0.005397184286266565,
0.03455035015940666,
0.0005442133406177163,
0.015074256807565689,
0.027899062260985374,
0.0314130038022995,
0.013867788016796112,
-0.0038441037759184837,
0.004582655616104603,
-0.009477078914642334,
0.008911541663110256,
-0.010171540081501007,
-0.019642148166894913,
0.004403514787554741,
0.0005496367812156677,
0.015539681538939476,
-0.017883870750665665,
0.0033485237509012222,
-0.013550613075494766,
0.008536671288311481,
0.011865051463246346,
0.009902194142341614,
-0.009439035318791866,
0.030803132802248,
0.0054582227021455765,
-0.007588219363242388,
-0.007595819421112537,
-0.015033293515443802,
-0.016225047409534454,
0.0063201081939041615,
0.0253155454993248,
-0.011255843564867973,
-0.010052199475467205,
-0.0040232520550489426,
-0.01995041035115719,
0.012496672570705414,
-0.007556397467851639,
-0.0188792385160923,
0.032374411821365356,
0.0066279079765081406,
0.008226591162383556,
-0.019858701154589653,
0.018815627321600914,
0.028520260006189346,
-0.020806530490517616,
0.03572740778326988,
-0.027715547010302544,
0.00955516193062067,
-0.006083937361836433,
-0.0021142899058759212,
0.009649236686527729,
-0.012406941503286362,
-0.036903828382492065,
0.00567355053499341,
0.010703903622925282,
0.015970315784215927,
0.01672477461397648,
0.02348945662379265,
0.005325697362422943,
-0.00007583049591630697,
-0.019247855991125107,
0.01313155610114336,
0.009865282103419304,
-0.0018646884709596634,
0.008421805687248707,
0.011154686100780964,
0.014874374493956566,
-0.04248133301734924,
0.0007557538338005543,
0.0024375119246542454,
0.007958837784826756,
0.012398796156048775,
-0.009494181722402573,
-0.0020505720749497414,
-0.012079538777470589,
-0.01444944366812706,
-0.004278412088751793,
0.004515307955443859,
-0.021032489836215973,
0.0012659798376262188,
-0.03335560858249664,
-0.014063755050301552,
-0.003110626246780157,
-0.0050509013235569,
-0.030433248728513718,
0.01638619229197502,
0.0022963639348745346,
0.011482501402497292,
-0.008336048573255539,
-0.0151761993765831,
-0.01723342016339302,
0.028081154450774193,
-0.012104560621082783,
-0.0004264421295374632,
0.009559079073369503,
-0.00515070790424943,
-0.007467091549187899,
-0.009914271533489227,
-0.012419452890753746,
0.006297781132161617,
-0.0066636428236961365,
-0.028552837669849396,
-0.01377029251307249,
-0.01729421503841877,
-0.0035684104077517986,
0.00029694801196455956,
0.002018611179664731,
-0.01998976059257984
] | [
0.6754284501075745,
0.625907301902771,
-0.18843938410282135,
0.2736658453941345,
0.11904700100421906,
0.5084854364395142,
0.8398346900939941,
0.5371489524841309,
-0.252621054649353,
-0.7126936316490173,
0.14792783558368683,
0.6215736269950867,
-0.41344356536865234,
0.21464771032333374,
-0.6865994334220886,
0.06932733952999115,
0.5480724573135376,
0.5587056279182434,
-0.020045358687639236,
-0.16170428693294525,
-0.3773050904273987,
0.08740225434303284,
0.48396873474121094,
-0.4617646634578705,
0.006443444639444351,
0.021605804562568665,
-0.10275626182556152,
0.09775674343109131,
-0.45117148756980896,
-0.2231881469488144,
0.06096741184592247,
0.2814376652240753,
-0.141211599111557,
-0.09183500707149506,
-0.10481485724449158,
-0.1425255835056305,
-0.27137434482574463,
-0.25608402490615845,
-0.40606629848480225,
-0.17899194359779358,
0.28117817640304565,
-0.15631338953971863,
-0.49743422865867615,
0.36298203468322754,
-0.7274032235145569,
-0.3197343945503235,
-1.3963425159454346,
0.4181059002876282,
-0.5471352934837341,
0.20468147099018097,
-0.1906135082244873,
0.31512221693992615,
0.24306800961494446,
0.46103450655937195,
0.0609854981303215,
0.5732723474502563,
0.16972628235816956,
0.0977582111954689,
-0.21589474380016327,
-0.20834550261497498,
0.31947198510169983,
-0.04094954952597618,
-0.36253926157951355,
0.1545685976743698,
0.0929180458188057,
0.5055763721466064,
0.5335376858711243,
-0.1928400844335556,
-0.01672983728349209,
-0.32630136609077454,
-0.0947081446647644,
-0.8107650876045227,
-0.24771183729171753,
0.3517574965953827,
-0.5230433344841003,
-0.4625266492366791,
0.09409897029399872,
-0.43072912096977234,
0.4067881405353546,
-0.25376203656196594,
0.03025207296013832,
0.6088918447494507,
0.3227216899394989,
-0.2792919874191284,
0.3691113293170929,
0.008113342337310314,
0.1196327805519104,
0.7471457123756409,
-0.30068743228912354,
0.06497462838888168,
0.3521777093410492,
-0.45078763365745544,
0.23029442131519318,
0.06256169080734253,
0.27765318751335144,
0.3359646797180176,
0.5625202059745789,
-0.24992536008358002,
0.23188021779060364,
0.05565324425697327,
-0.25206974148750305,
0.06464092433452606,
0.16476094722747803,
-0.08472242206335068,
0.3781374990940094,
-0.33398735523223877,
0.38792669773101807,
-0.6525311470031738,
-0.22949175536632538,
0.3445839285850525,
-0.32384833693504333,
0.04820536822080612,
-0.39750978350639343,
0.11649356037378311,
-0.6850675344467163,
0.3528473675251007,
0.06226437911391258,
-0.03734801709651947,
-0.26838451623916626,
-0.03937730938196182,
0.4364192485809326,
0.4944130480289459,
0.2416490614414215,
-0.20135001838207245,
0.3939720690250397,
0.18898607790470123,
0.20477139949798584,
-0.11901777982711792,
0.23821531236171722,
0.41449034214019775,
0.34394457936286926,
1.1602915525436401,
-0.4235943853855133,
-0.24887549877166748,
0.47409147024154663,
-0.2565043568611145,
0.46759045124053955,
0.2595272660255432,
0.09334255009889603,
-0.12379665672779083,
-0.4437539875507355,
-0.5061333775520325,
-0.26285603642463684,
-0.050048112869262695,
-0.04804011434316635,
-0.1888219118118286,
-0.237589493393898,
0.10326825082302094,
-0.16088424623012543,
-0.13354060053825378,
-0.29659274220466614,
-0.0700310468673706,
-0.4957147538661957,
-0.03920058533549309,
0.24553678929805756,
0.6380271911621094,
0.041821327060461044,
-0.11727496236562729,
-0.272487074136734,
0.2752302289009094,
0.23821493983268738,
0.5645991563796997,
-0.6935110688209534,
-0.7985207438468933,
-0.09167744964361191,
-0.557536244392395,
0.015002649277448654,
0.6349186897277832,
0.34514427185058594,
0.009850743226706982,
-0.34731975197792053,
-0.008202997967600822,
0.07112453132867813,
-0.693078339099884,
0.07424332946538925,
0.23735664784908295,
0.18742792308330536,
0.18296895921230316,
0.5145728588104248,
0.34687530994415283,
-0.7360410094261169,
0.2936456799507141,
-0.08393112570047379,
-0.25647076964378357,
0.30500152707099915,
-0.32897526025772095,
0.39989301562309265,
-0.0684163048863411,
-0.5873534083366394,
-0.11134296655654907,
-0.658236563205719,
-0.4424542784690857,
0.5329022407531738,
-0.600421667098999,
0.8065189719200134,
-0.076250821352005,
-0.5328933000564575,
0.9234286546707153,
-0.10281907767057419,
-0.11353679746389389,
-0.3712683320045471,
0.4391058683395386,
-0.02123558707535267,
-0.5487580299377441,
-1.049616813659668,
0.41087061166763306,
0.39732667803764343,
0.009308131411671638,
-0.08221224695444107,
0.13566960394382477,
0.7906559109687805,
0.07067865878343582,
-0.15230649709701538,
-0.6229535937309265,
-0.15392957627773285,
0.29498979449272156,
0.11151747405529022,
-0.10673065483570099,
-0.026810141280293465,
-0.1609543263912201,
0.7116263508796692,
-0.17106229066848755,
0.8094009160995483,
0.9484808444976807,
-0.06316705793142319,
0.6110275387763977,
0.5591353178024292,
0.22087936103343964,
0.9009466767311096,
-0.6118922233581543,
0.22533018887043,
-0.08368054777383804,
0.5090122818946838,
-0.05174956098198891,
-0.5973767638206482,
0.279664546251297,
0.02396201901137829,
-0.13840284943580627,
0.15625731647014618,
0.04588975012302399,
-0.37998366355895996,
0.26275697350502014,
-0.5221050381660461,
0.38644492626190186,
-0.01827448420226574,
-0.31913676857948303,
-0.5848544239997864,
0.1383473426103592,
-0.6627704501152039,
0.0953744575381279,
-0.25989583134651184,
0.5006973743438721,
0.0469924621284008,
-0.3443114757537842,
-0.17265665531158447,
-0.07573909312486649,
-0.44781559705734253,
-0.2615545094013214,
0.31017830967903137,
-0.018544698134064674,
-0.47375112771987915,
-0.21708939969539642,
-0.03356977552175522,
0.18393339216709137,
-0.3609277904033661,
-0.5166280269622803,
-0.3542258143424988,
-0.4728682041168213,
0.12715719640254974,
0.6071372032165527,
0.5753597021102905,
0.10865253955125809,
-0.6685893535614014,
0.259535551071167,
0.3816749155521393,
-0.1795300990343094,
0.11917360872030258,
0.5883718132972717,
-0.5947315096855164,
-0.11562726646661758,
0.29076704382896423,
0.987159252166748,
0.6746998429298401,
-0.6869150996208191,
-0.3547202944755554,
-0.018856745213270187,
0.08397343009710312,
-0.3451416790485382,
-0.5526047348976135,
0.16966886818408966,
-0.7220102548599243,
0.09473957121372223,
-0.1733018010854721,
-0.5189647078514099,
0.6984188556671143,
0.0957791730761528,
0.20767521858215332,
-0.04622890055179596,
0.50685715675354,
-0.3505949378013611,
0.1611570417881012,
0.7315644025802612,
-0.09086097776889801,
-0.2112654447555542,
0.016929980367422104,
0.14005175232887268,
-0.3009633421897888,
0.05565798655152321,
-6.006407737731934,
-0.5619100332260132,
-0.15216432511806488,
-0.052080485969781876,
-0.08920840919017792,
-0.09440536051988602,
1.1345932483673096,
-0.014720689505338669,
-0.09412054717540741,
0.3413889408111572,
0.5345308184623718,
0.398295521736145,
0.5443152189254761,
0.5350645780563354,
0.03473244979977608,
-0.4112304151058197,
0.7549442052841187,
0.3595527708530426,
-0.024226481094956398,
0.5865861177444458,
0.09931299090385437,
-0.03231930360198021,
-0.11474783718585968,
0.5371992588043213,
0.4010362923145294,
-0.09991095215082169,
-0.6110584139823914,
0.23947374522686005,
-0.11315222829580307,
-0.2688482403755188,
-0.04082070663571358,
-0.17105761170387268,
-0.16453880071640015,
-0.5787323117256165,
0.33303678035736084,
0.0010960857616737485,
0.07412093132734299,
-0.2755371630191803,
0.2446431815624237,
-0.13451315462589264,
-0.17603662610054016,
-0.19691552221775055,
0.2837012708187103,
-0.19197092950344086,
0.1411755383014679,
-0.06426665931940079,
-0.39917001128196716,
0.02189267799258232,
-0.005749037489295006,
0.5588010549545288,
0.14726725220680237,
0.20315271615982056,
0.5742141604423523,
0.13718165457248688,
0.13496924936771393,
0.021235063672065735,
0.4180290699005127,
0.5389000773429871,
-0.4398003816604614,
0.01807205006480217,
0.09389597922563553,
-0.07005604356527328,
-0.055302008986473083,
-0.5950348377227783,
-0.04106780141592026,
0.1847725212574005,
-0.3283798396587372,
-0.6932514309883118,
0.4728114604949951,
-0.2154090702533722,
-0.7239294648170471,
0.17064915597438812,
0.5011875629425049,
-0.556267261505127,
0.349307119846344,
-0.4026467800140381,
-0.13632112741470337,
0.33126384019851685,
0.10630591958761215,
-0.11906512081623077,
-0.08648708462715149,
-0.46001091599464417,
-0.1054716482758522,
-0.41945797204971313,
0.21973294019699097,
-0.4493218660354614,
0.3932860791683197,
-0.07802173495292664,
-0.12005334347486496,
0.2769905626773834,
0.8449298739433289,
-0.05151311680674553,
0.28058061003685,
0.2564493417739868,
0.6304205656051636,
0.5556275844573975,
0.3760383725166321,
0.39051324129104614,
0.2434045523405075,
-0.327075719833374,
0.26784560084342957,
-0.35539165139198303,
0.09673915058374405,
-0.8504664897918701,
-0.5569912791252136,
-0.03493272140622139,
-0.5136556625366211,
-0.10420633852481842,
0.5298208594322205,
-0.5671156644821167,
0.12101917713880539,
-0.046681057661771774,
-0.37524503469467163,
0.05205328390002251,
0.22666816413402557,
0.08913759142160416,
0.047947999089956284,
0.2836126387119293,
0.12270049750804901,
-0.1601753979921341,
0.4459253251552582,
0.19704841077327728,
-0.6081364750862122,
-0.2264930158853531,
0.16412010788917542,
-0.2914992570877075,
-0.11642193049192429,
0.7287777066230774,
-0.04046822339296341,
0.10929490625858307,
0.2892051041126251,
0.6048188805580139,
-0.07749774307012558,
-0.028501655906438828,
0.29040682315826416,
-0.01218517404049635,
-0.14013457298278809,
0.44297173619270325,
-0.08718044310808182,
-0.41842442750930786,
0.784968376159668,
-0.11937041580677032,
-0.20832450687885284,
0.003646708792075515,
0.12576593458652496,
-0.16850586235523224,
-0.3177439570426941,
-0.3132709860801697,
0.5940505266189575,
0.1294824182987213,
-0.18843506276607513,
-0.19008605182170868,
0.18834607303142548,
0.17057904601097107,
-0.06029009819030762,
-0.21002303063869476,
0.2990720868110657,
-0.06699144840240479,
-0.6172572374343872,
-0.5806596279144287,
-0.05092120170593262,
-0.016537869349122047,
-1.129835605621338,
-0.04658009484410286,
0.27842217683792114,
0.18783162534236908,
-0.21772286295890808,
-0.5261383652687073,
-0.02640671841800213,
0.7437262535095215,
0.034045759588479996,
0.2370888590812683,
-0.31113186478614807,
0.12092893570661545,
0.08424707502126694,
-0.3843589425086975,
-0.20315806567668915,
-0.13363328576087952,
-0.03716647997498512,
0.11033730208873749,
0.18479090929031372,
0.17408765852451324,
0.03437475487589836,
-0.03220511972904205,
-0.14577339589595795,
-0.3713400661945343,
0.38743746280670166,
0.15198159217834473,
-0.4067007601261139,
-0.41023892164230347,
-0.02913467027246952,
-0.14546507596969604,
0.6293084025382996,
-0.1860853135585785,
0.32217302918434143,
0.184126615524292,
0.1879517138004303,
0.4506564736366272,
-0.1062811091542244,
0.050524257123470306,
0.5006352663040161,
0.19227762520313263,
-0.7645715475082397,
-0.2086000144481659,
0.5214208960533142,
-0.9632594585418701,
-0.23394310474395752,
0.10093844681978226,
0.12482362985610962,
0.22743967175483704,
-0.9119710922241211,
-0.05683153495192528,
-0.0011748007964342833,
0.2978420555591583,
-0.44211119413375854,
-0.4491208791732788,
0.3327774107456207,
-0.015982935205101967,
-0.41352784633636475,
0.02937590703368187,
-0.05618319287896156,
0.011724618263542652,
-0.47219979763031006,
-0.07716996222734451,
-0.24722908437252045,
-0.5636988878250122,
0.642932653427124,
-0.4453805983066559,
0.3725742995738983,
0.016632961109280586,
-0.31817397475242615,
0.29889822006225586,
0.4997379183769226,
-0.33796191215515137,
-0.08637893944978714,
-0.462908536195755,
0.38562652468681335,
0.36540883779525757,
0.19952905178070068,
-0.3700120449066162,
-0.5037532448768616,
0.32187455892562866,
-0.32850903272628784,
-0.4869406819343567,
0.02567962184548378,
0.25874727964401245,
0.2752768397331238,
-0.6670944094657898,
-0.34351590275764465,
0.38991299271583557,
0.2282736450433731,
0.1106414943933487,
-0.08841197937726974,
0.010241389274597168,
-0.07154908776283264,
-0.1854790598154068,
-0.09630186855792999,
-0.7302618622779846,
0.13391441106796265,
-0.03359585255384445,
-0.0844983235001564,
-0.5794844627380371,
0.08530409634113312,
-0.39902207255363464,
0.4134924113750458,
-0.01594357006251812,
-0.452055960893631,
-0.246451735496521,
0.26013100147247314,
-0.777348518371582,
0.6120052933692932,
0.12681494653224945,
0.21450160443782806,
0.22561527788639069,
0.15434658527374268,
-0.23504213988780975,
-0.6043601632118225,
0.02424473874270916,
-0.34829357266426086,
-0.3476020097732544,
0.46238794922828674,
0.09825921058654785,
-0.09283193200826645,
-0.5415864586830139,
0.36614400148391724,
-0.5627186894416809,
0.5622067451477051,
-0.32843002676963806,
-0.5497881174087524,
-0.2919851541519165,
-0.23772846162319183,
0.21457229554653168,
-0.4005659818649292,
0.09094582498073578,
-0.011505565606057644,
-0.13160450756549835,
0.13393431901931763,
0.18551577627658844,
0.03751879557967186,
-0.1489938497543335,
0.03581076115369797,
-0.003722031367942691,
0.629612922668457,
-0.5590450167655945,
0.18516309559345245,
0.36950892210006714,
-0.24793082475662231,
0.00726073095574975,
-0.2726157307624817,
-0.052039436995983124,
0.1534242182970047,
-0.03349234536290169,
0.26412659883499146,
0.46196362376213074,
-0.4535813629627228,
-0.5692751407623291,
-0.14611665904521942,
-0.8434834480285645,
0.5371884107589722,
0.2923130989074707,
-0.16684602200984955,
-0.055669888854026794,
0.41766247153282166,
-0.08129789680242538,
-0.021033354103565216,
0.5098977088928223,
-0.18526466190814972,
0.5257049798965454,
-0.02516249381005764,
0.6198087930679321,
0.46986788511276245,
0.6404736638069153,
-0.0500791035592556,
-0.4482848644256592,
0.2060154229402542,
-0.2375892549753189,
0.20619861781597137,
-0.39390623569488525,
-0.3421439230442047,
0.41849368810653687,
0.7758434414863586,
-0.42849230766296387,
0.3448423743247986,
0.17602579295635223,
-0.17343004047870636,
0.6278727650642395,
0.460907518863678,
0.11387518048286438,
-0.34273603558540344,
0.4253317415714264,
0.1670466810464859,
-0.4118538796901703,
0.19683118164539337,
0.18017876148223877,
-0.23769132792949677,
-0.5991088151931763,
0.015048866160213947,
-0.02078224904835224,
-0.2857351303100586,
0.3650582432746887,
0.02576599083840847,
0.020517971366643906,
-0.29686734080314636,
0.19521760940551758,
0.25908827781677246,
-0.2145915925502777,
0.4683263301849365,
0.014344017021358013,
0.3419044613838196,
-0.3756278157234192,
-0.20833083987236023,
0.27491238713264465,
-0.8318736553192139,
0.7562580108642578,
0.23244324326515198,
-0.4718368351459503,
0.729561448097229,
0.06831948459148407,
-0.022266868501901627,
-0.1384611278772354,
0.16523809731006622,
0.43481945991516113,
-0.13574309647083282,
-0.444173663854599,
-0.1442263424396515,
0.18578818440437317,
-0.29130232334136963,
0.014538475312292576,
-0.0029035492334514856,
-0.1819600909948349,
0.310754656791687,
-0.38389068841934204,
-0.5584815740585327,
0.4333770275115967,
-0.29348430037498474,
-0.27277275919914246,
0.09144891053438187,
0.313687264919281,
0.2864176034927368,
0.010847196914255619,
0.22141776978969574,
0.35716673731803894,
-0.28270626068115234,
0.4723018705844879,
-0.8179355263710022,
-0.053526949137449265,
-0.47414350509643555,
-0.25237810611724854,
-0.5651662945747375,
-0.2340465486049652,
0.3893626034259796,
0.30415448546409607,
0.0775318592786789,
0.07033604383468628,
0.02779553458094597,
0.03871098905801773,
0.22368118166923523,
-0.4092633128166199,
0.18453656136989594,
-0.28733932971954346,
-0.13498903810977936,
-0.6814266443252563,
0.30651479959487915,
-0.26592254638671875,
0.21707750856876373,
-0.48292407393455505,
0.09157736599445343,
0.35184207558631897,
-0.22175846993923187,
0.6224573254585266,
-0.9261054396629333,
0.43313947319984436,
-0.20127533376216888,
0.6257823705673218,
-0.18223491311073303,
-0.37532636523246765,
0.38364309072494507,
0.25158360600471497,
0.41964271664619446,
-0.7009700536727905,
-0.19569464027881622,
-0.3621993958950043,
-0.27856576442718506,
0.22326377034187317,
-0.19192063808441162,
0.30523207783699036,
-0.1282196044921875,
-0.26757118105888367,
-0.20398291945457458,
0.44454216957092285,
0.1598890870809555,
-0.33001261949539185,
-0.07411153614521027,
-0.11994785815477371,
-0.4092700779438019,
-0.057740647345781326,
0.38650983572006226,
-0.3307131230831146,
-0.145570769906044,
0.027742881327867508
] |
The incidence of malignant neoplasms among 11 483 male and 34 618 female individuals with rheumatoid arthritis was studied using two separate nationwide data registers covering the whole Finnish population: the Social Insurance Institution9s Population Data Register, which includes information on medication for certain chronic diseases, and the Finnish Cancer Registry, with data on all cancer patients diagnosed in Finland. The follow-up comprised a total of 213 911 person years. The total incidence of all malignant neoplasms was higher in males and on the level expected in females. The expected number of cases of leukemia, lymphomas, Hodgkin9s disease and myeloma in both sexes was 59·6 as compared with the 130 cases observed. This difference is statistically highly significant (p | [
0.025648094713687897,
0.0026707076467573643,
-0.02117929607629776,
0.01834062486886978,
0.01833050325512886,
-0.0015155578730627894,
0.009060082025825977,
0.006054156459867954,
-0.0164242684841156,
0.005095614120364189,
0.00683150440454483,
0.009150030091404915,
-0.00934523530304432,
0.011527594178915024,
0.012276892550289631,
-0.026888646185398102,
-0.043447185307741165,
0.006580416578799486,
0.013684459030628204,
0.012074131518602371,
0.01882302574813366,
-0.013645018450915813,
0.008922247216105461,
0.023260898888111115,
0.02296745590865612,
0.007093520835042,
-0.019412046298384666,
-0.006725641433149576,
0.008094961754977703,
0.021788790822029114,
0.010540008544921875,
0.03013363853096962,
0.0188969187438488,
0.0027857953682541847,
0.020599205046892166,
0.008181201294064522,
0.0010469445260241628,
0.014108124189078808,
-0.01682916283607483,
-0.0054947747848927975,
0.03510319069027901,
-0.009478602558374405,
0.00018975994316861033,
0.022417252883315086,
-0.006493148859590292,
0.020208552479743958,
-0.011417201720178127,
0.011711519211530685,
-0.0027517706621438265,
0.010935526341199875,
-0.010570899583399296,
0.008479534648358822,
-0.026002299040555954,
-0.024234147742390633,
-0.005919240415096283,
0.052918531000614166,
0.017613694071769714,
0.028826072812080383,
-0.004146590828895569,
-0.022687911987304688,
0.01769675686955452,
-0.03503572195768356,
0.013773750513792038,
0.014365678653120995,
-0.004085227847099304,
-0.06691133975982666,
0.03809179738163948,
-0.005894074682146311,
-0.018651248887181282,
-0.005532330833375454,
-0.011888938024640083,
0.0025446335785090923,
0.015310365706682205,
-0.010431620292365551,
-0.02360350266098976,
0.011050056666135788,
0.004729371052235365,
-0.03684050589799881,
-0.0016178558580577374,
0.016560882329940796,
0.025534212589263916,
0.00021116912830621004,
-0.013535487465560436,
0.01825973019003868,
-0.011648694053292274,
0.017910541966557503,
-0.0320855975151062,
-0.017839806154370308,
-0.0006925922352820635,
0.036493826657533646,
0.01476877462118864,
0.014160869643092155,
-0.03639673441648483,
0.005168839357793331,
-0.023577524349093437,
0.008400237187743187,
0.00251743639819324,
-0.01055990345776081,
0.0068333204835653305,
-0.005096026696264744,
-0.0016732004005461931,
-0.0014770305715501308,
0.018077807500958443,
0.019040405750274658,
-0.01548993494361639,
0.013140845112502575,
0.0020946040749549866,
0.006638146936893463,
0.0329815074801445,
0.004789958707988262,
-0.0011614176910370588,
0.0018159961327910423,
0.006740940734744072,
0.005231460556387901,
-0.011168010532855988,
-0.005350377876311541,
-0.00014552066568285227,
0.0006844042800366879,
-0.0011322653153911233,
-0.02409921959042549,
0.016913767904043198,
-0.0018018315313383937,
-0.009163598529994488,
0.021092914044857025,
-0.003147271927446127,
-0.004108764231204987,
0.05180876702070236,
-0.0009673144668340683,
0.03194095939397812,
-0.004512682557106018,
-0.004673682153224945,
0.006035615690052509,
-0.016776271164417267,
-0.04277881234884262,
0.004028918221592903,
-0.0005058462847955525,
0.008328132331371307,
-0.0016320704016834497,
-0.018055347725749016,
-0.008037356659770012,
0.000637345714494586,
0.009617879986763,
0.0076712751761078835,
0.007684411481022835,
0.019188646227121353,
-0.002512564416974783,
0.013013262301683426,
0.019261527806520462,
0.015989098697900772,
-0.010009799152612686,
0.002909936010837555,
0.014626316726207733,
0.004294250626116991,
-0.01808919757604599,
0.016568206250667572,
0.004084184765815735,
-0.015214445069432259,
-0.004260124173015356,
-0.0037025532219558954,
0.013678123243153095,
0.011498375795781612,
0.0006866964977234602,
0.0021597950253635645,
0.008039695210754871,
0.0052268411964178085,
0.006617027334868908,
0.003889160230755806,
-0.009236888028681278,
0.004993158392608166,
0.004537946078926325,
0.010179394856095314,
-0.0070821973495185375,
-0.01796683482825756,
0.006784724071621895,
-0.00886108074337244,
-0.0033843116834759712,
0.005588546395301819,
0.006034370511770248,
0.0026837566401809454,
0.06706573069095612,
-0.012380296364426613,
0.024705400690436363,
0.018952935934066772,
-0.013540126383304596,
0.013442897237837315,
-0.006880997680127621,
0.0003048329381272197,
-0.014067540876567364,
-0.013822603970766068,
0.03101377934217453,
0.031933851540088654,
0.020906541496515274,
-0.02666429802775383,
0.015312762930989265,
-0.007703498937189579,
0.003997362218797207,
-0.0035647633485496044,
0.00657418929040432,
0.014074228703975677,
0.025472227483987808,
-0.010303562507033348,
0.0002394330222159624,
0.012451850809156895,
-0.0008763326331973076,
-0.003397815627977252,
0.018690213561058044,
0.023672696202993393,
0.00256063649430871,
0.011715536937117577,
-0.0010223310673609376,
0.009196512401103973,
-0.013502784073352814,
-0.014498603530228138,
-0.017725709825754166,
0.042828574776649475,
0.008551821112632751,
-0.00354220368899405,
0.007783253211528063,
-0.02230151556432247,
-0.01297489833086729,
0.0006892584497109056,
0.013518917374312878,
-0.016363326460123062,
0.010216845199465752,
0.001400959910824895,
-0.010022705420851707,
0.02409718930721283,
0.005704575218260288,
0.02171318233013153,
-0.010441586375236511,
-0.008415286429226398,
-0.019336096942424774,
-0.009004153311252594,
0.0019383018370717764,
0.010857202112674713,
0.01628432609140873,
0.013571852818131447,
-0.01890147663652897,
0.017043722793459892,
-0.01778421923518181,
0.009847319684922695,
-0.006726409308612347,
-0.002089274348691106,
-0.003617989830672741,
0.018062952905893326,
0.004867314361035824,
0.04376918449997902,
-0.005370728671550751,
-0.010899469256401062,
-0.006185515783727169,
0.007072797045111656,
-0.01778518222272396,
0.02119101770222187,
-0.002773934043943882,
0.027362989261746407,
-0.0019164264667779207,
0.001785285770893097,
-0.002787905279546976,
0.024702444672584534,
-0.008187580853700638,
0.02773170731961727,
0.009191842749714851,
0.006748918443918228,
-0.0005513366777449846,
0.004823607392609119,
-0.02271459251642227,
-0.01575063169002533,
-0.02031531371176243,
0.005082763731479645,
-0.001056064385920763,
0.006905111484229565,
-0.01439655851572752,
-0.002892052289098501,
-0.08130404353141785,
0.014692747965455055,
0.036196768283843994,
-0.00035080756060779095,
-0.0017404083628207445,
-0.013672789558768272,
0.007198478560894728,
0.01879470981657505,
0.011828293092548847,
-0.0027505685575306416,
-0.012437974102795124,
0.008007611148059368,
-0.0013448003446683288,
0.0016645756550133228,
0.01610180176794529,
0.003494716715067625,
0.0013026220258325338,
-0.0013665100559592247,
-0.022815536707639694,
0.0054802317172288895,
0.004942791070789099,
-0.003793533658608794,
0.018774613738059998,
-0.0242445170879364,
0.017468534409999847,
0.03877118229866028,
-0.00442799786105752,
0.010211676359176636,
-0.020324256271123886,
0.0025489008985459805,
-0.03581349924206734,
-0.04200194776058197,
-0.0030009308829903603,
-0.004254084080457687,
0.030898604542016983,
-0.0018346509896218777,
-0.014551627449691296,
0.023962344974279404,
0.0006925156340003014,
0.012890640646219254,
0.005046810954809189,
0.006026986055076122,
0.011405378580093384,
-0.013300003483891487,
0.014228567481040955,
0.008809220045804977,
0.012873148545622826,
0.040120892226696014,
0.015397787094116211,
-0.011626999825239182,
0.009330674074590206,
0.001762273139320314,
-0.0066815828904509544,
0.004490985535085201,
-0.0044863345101475716,
0.00008174299728125334,
-0.012117225676774979,
-0.010855861008167267,
-0.006041041575372219,
-0.009984150528907776,
0.0025512883439660072,
0.016296878457069397,
0.001483998610638082,
-0.008626229129731655,
0.006358285900205374,
-0.018398135900497437,
0.011442671529948711,
-0.008034400641918182,
-0.028811849653720856,
0.007322155870497227,
-0.015904998406767845,
-0.003956011962145567,
-0.011210812255740166,
-0.010860403999686241,
0.005959698930382729,
-0.006522540934383869,
-0.011194051243364811,
-0.0002895397483371198,
-0.00007206154987215996,
0.026777364313602448,
-0.028139935806393623,
-0.006319952197372913,
-0.008596483618021011,
0.018533917143940926,
-0.015825586393475533,
0.028219688683748245,
0.019572880119085312,
0.01810500957071781,
0.013593688607215881,
-0.025197945535182953,
0.04164116084575653,
0.014055108651518822,
-0.045202165842056274,
0.011470076628029346,
-0.0035467129200696945,
-0.004024983383715153,
-0.0031105359084904194,
-0.01143253967165947,
-0.010262131690979004,
0.007739834487438202,
0.002874271012842655,
-0.003538239048793912,
0.01970992051064968,
-0.010418491438031197,
0.005984891671687365,
0.014697118662297726,
0.006503683514893055,
-0.01767091453075409,
-0.004730516113340855,
-0.0023536526132375,
-0.004678771365433931,
0.005571473389863968,
-0.005694464314728975,
0.05668408051133156,
0.011722136288881302,
-0.012738630175590515,
0.002463649958372116,
-0.019148487597703934,
0.07246190309524536,
0.022596284747123718,
0.011312123388051987,
-0.029032478109002113,
0.010289950296282768,
-0.026194609701633453,
0.010490679182112217,
0.0009113588603213429,
-0.03359127417206764,
-0.0059028067626059055,
0.012125815264880657,
-0.0006464826874434948,
0.006185686215758324,
-0.027375292032957077,
-0.00041282299207523465,
0.01010347343981266,
0.013596299104392529,
0.023912843316793442,
0.021281026303768158,
0.003632455598562956,
-0.0027764555998146534,
-0.011536890640854836,
-0.02205682173371315,
-0.021688075736165047,
0.01586288958787918,
0.005710693076252937,
0.016500458121299744,
-0.011412389576435089,
-0.0026574013754725456,
0.00568404933437705,
-0.02714499831199646,
-0.0002120109274983406,
-0.004946799948811531,
0.001755937933921814,
0.001355318003334105,
-0.00023785722441971302,
-0.025202199816703796,
-0.005608097650110722,
0.012462539598345757,
-0.01375072356313467,
-0.0001417186576873064,
-0.005135675892233849,
-0.0014149565249681473,
0.009072734043002129,
-0.021263282746076584,
0.007226636167615652,
0.03030736930668354,
-0.008214671164751053,
-0.00655596936121583,
0.03159134089946747,
0.006554740015417337,
0.0053895460441708565,
0.013894964009523392,
0.002736125374212861,
-0.025500059127807617,
-0.010740910656750202,
0.023931510746479034,
-0.004666130058467388,
0.0024285423569381237,
-0.012374193407595158,
-0.0034998625051230192,
-0.010956022888422012,
0.021213460713624954,
-0.0017713173292577267,
-0.007001257501542568,
-0.019499270245432854,
-0.02390669286251068,
-0.0033365136478096247,
-0.01794903352856636,
-0.025242894887924194,
-0.0068439459428191185,
-0.01553127821534872,
0.017194919288158417,
-0.028436671942472458,
-0.025850597769021988,
-0.0026784290093928576,
-0.016316082328557968,
-0.0040528434328734875,
0.015594826079905033,
-0.022698797285556793,
0.015193862840533257,
-0.00007838429883122444,
0.005924464203417301,
-0.008065436035394669,
0.004574769642204046,
-0.026507902890443802,
-0.016695860773324966,
-0.07451379299163818,
-0.006539380177855492,
0.0019904610235244036,
-0.007951561361551285,
-0.0032935673370957375,
0.003952449187636375,
-0.015515903942286968,
0.017787987366318703,
-0.010634069330990314,
-0.006434385199099779,
0.007337826304137707,
0.013392344117164612,
0.020796947181224823,
-0.021056389436125755,
0.015798429027199745,
-0.02377420663833618,
0.013076725415885448,
-0.007115189917385578,
-0.00821615755558014,
-0.015995541587471962,
0.05054996907711029,
0.005852244794368744,
-0.010563823394477367,
0.010202922858297825,
-0.005719071254134178,
-0.08141915500164032,
0.009895453229546547,
-0.008296806365251541,
-0.0035840386990457773,
0.0010193209163844585,
-0.016942095011472702,
0.014542308636009693,
-0.02247273549437523,
-0.022641558200120926,
-0.016005244106054306,
-0.014424840919673443,
-0.0005612296517938375,
0.011569518595933914,
0.008117132820189,
-0.0022116401232779026,
-0.004040081985294819,
0.02767358347773552,
0.007511372212320566,
-0.02706483006477356,
-0.011066030710935593,
-0.03253651410341263,
0.014926392585039139,
0.002084022620692849,
0.012943385168910027,
-0.006077672354876995,
0.009507021866738796,
-0.01439256314188242,
0.010405397973954678,
0.019022449851036072,
0.004032971803098917,
0.012207407504320145,
-0.01150221936404705,
-0.009878184646368027,
-0.012911694124341011,
-0.02986104227602482,
-0.019877754151821136,
0.016110537573695183,
-0.013747160322964191,
0.004393598064780235,
-0.012065691873431206,
-0.0010919272899627686,
0.029724277555942535,
0.02605222351849079,
0.00689614238217473,
-0.01336107961833477,
-0.007534294854849577,
0.012212345376610756,
-0.01257949136197567,
0.02031840570271015,
0.02148728258907795,
0.00416009034961462,
-0.024398135021328926,
-0.026017777621746063,
0.012379670515656471,
0.014173882082104683,
0.016447508707642555,
-0.005389781668782234,
0.004993019159883261,
0.007417818531394005,
0.025893060490489006,
-0.0012723635882139206,
-0.03218488395214081,
0.0028440009336918592,
0.07180895656347275,
-0.006674515549093485,
0.0076425098814070225,
-0.012349250726401806,
0.0051661948673427105,
0.0006348355091176927,
0.004304250702261925,
0.003412490477785468,
-0.010813751257956028,
-0.001229912624694407,
-0.0037944866344332695,
-0.014891047030687332,
0.005036484450101852,
0.0141442334279418,
0.02334677428007126,
-0.02054133266210556,
-0.004315221682190895,
0.028562035411596298,
-0.04788193106651306,
0.0009171201381832361,
0.007745593786239624,
0.010883811861276627,
-0.00670914351940155,
-0.019722457975149155,
-0.0017662043683230877,
-0.008852839469909668,
0.019227152690291405,
-0.0012095833662897348,
-0.005862550809979439,
0.030954282730817795,
-0.007073860615491867,
0.021935682743787766,
0.008935991674661636,
0.015594320371747017,
0.0013367364881560206,
0.01856311224400997,
0.0025548874400556087,
0.013125385157763958,
-0.004202878102660179,
0.004156298935413361,
0.01870056614279747,
-0.03816245496273041,
0.014460752718150616,
-0.016581537202000618,
0.025318866595625877,
-0.003676842199638486,
-0.0072424402460455894,
-0.005018023774027824,
-0.00835465919226408,
0.008331929333508015,
-0.009445372968912125,
0.015291093848645687,
-0.008670817129313946,
-0.011769208125770092,
-0.003036074573174119,
-0.006457161158323288,
0.011170229874551296,
0.030091073364019394,
0.01658075861632824,
0.00034805922769010067,
0.002507168333977461,
0.00593909714370966,
-0.0013599935919046402,
-0.015601078979671001,
0.004597024992108345,
0.014810227788984776,
0.007007652893662453,
-0.014634793624281883,
0.012022598646581173,
0.012954941019415855,
-0.026660246774554253,
0.014867361634969711,
0.007924026809632778,
-0.004520107991993427,
0.0014625386102125049,
0.030441278591752052,
-0.029624752700328827,
-0.0030529808718711138,
-0.005705126561224461,
0.001960696652531624,
-0.00704855564981699,
0.02888079360127449,
0.009200604632496834,
-0.028454527258872986,
-0.019585231319069862,
0.03204665333032608,
0.02025909349322319,
0.004666726104915142,
-0.006833758670836687,
0.0002963404403999448,
0.01203797198832035,
0.008217302151024342,
0.00007922970689833164,
0.026457833126187325,
0.011586213484406471,
0.035246897488832474,
-0.008067864924669266,
0.001819453202188015,
0.007973390631377697,
0.020193468779325485,
-0.011935466900467873,
-0.018506884574890137,
-0.003211671020835638,
0.011159319430589676,
-0.02752404287457466,
0.004948906600475311,
-0.0025115800090134144,
-0.0069145988672971725,
-0.014041930437088013,
0.0014406200498342514,
0.005946372635662556,
0.008829282596707344,
0.01600569486618042,
0.0169767327606678,
0.012791883200407028,
0.022129062563180923,
0.011562331579625607,
-0.01210653968155384,
0.004944704007357359,
-0.01299799419939518,
-0.011440462432801723,
-0.024610409513115883,
-0.022122517228126526,
0.003360569942742586,
-0.007037220988422632,
0.012129101902246475,
-0.0015239312779158354,
0.006615323945879936,
0.0012909395154565573,
-0.0022534227464348078,
0.01935267448425293,
-0.002796898828819394,
0.00021764589473605156,
0.017668023705482483,
-0.015269894152879715,
0.008556487038731575,
0.0036176741123199463,
0.004383887629956007,
0.004219437018036842,
-0.010208997875452042,
-0.02054399810731411,
-0.021458186209201813,
0.007381519302725792,
-0.010764416307210922,
0.008946760557591915,
0.012461123988032341,
0.026403862982988358,
0.024563521146774292,
0.005138332024216652,
-0.012256255373358727,
0.0019732648506760597,
-0.0008816401241347194,
0.01640487276017666,
-0.0055933427065610886,
-0.010475948452949524,
-0.007440807297825813,
0.014920312911272049,
-0.012651067227125168,
0.022936290130019188,
0.020459942519664764,
-0.0013362852623686194,
-0.005721301306039095,
-0.013007656671106815,
-0.01595173589885235,
0.007880515418946743,
-0.0007756489794701338,
-0.032738931477069855,
0.016086207702755928,
0.006865205243229866,
0.01621459238231182,
0.000978715717792511,
-0.002474543172866106,
-0.011331962421536446,
0.007577804382890463,
-0.03117876686155796,
-0.00278168311342597,
-0.011717461049556732,
-0.013769246637821198,
-0.0056282333098351955,
0.004882276523858309,
-0.00032379082404077053,
0.00007570046000182629,
0.0015576466685160995,
-0.011892590671777725,
-0.004558070097118616,
0.021174971014261246,
-0.005395215004682541,
-0.0010781391756609082,
0.0012269162107259035,
-0.01611817628145218,
-0.019081827253103256,
0.002900628140196204,
-0.014625518582761288,
-0.008603573776781559,
-0.015111970715224743,
0.007395231164991856,
0.003192028496414423,
-0.026442956179380417,
0.0022840755991637707,
0.00041739270091056824,
0.008781110867857933,
-0.015688490122556686
] | [
0.22607773542404175,
0.20412182807922363,
0.012243503704667091,
-0.015168746002018452,
0.04219507798552513,
0.91969895362854,
0.9443981647491455,
-0.07760439813137054,
-0.7196727395057678,
-0.09240072965621948,
0.07789165526628494,
0.21250739693641663,
-0.11754804849624634,
0.5421746373176575,
0.23978371918201447,
0.5374295115470886,
0.61069256067276,
0.06883905827999115,
-0.1651264876127243,
-0.31608837842941284,
-0.4953567385673523,
-0.21449576318264008,
1.3780031204223633,
-0.0669480413198471,
-0.5323403477668762,
-0.07590761035680771,
0.5536416172981262,
0.17820127308368683,
-0.3000340461730957,
0.2722649574279785,
-0.3169369399547577,
0.7526088953018188,
0.2226646989583969,
-0.3818339705467224,
0.2021479606628418,
0.04095834866166115,
0.19694745540618896,
-0.3439909815788269,
0.03876496106386185,
-0.415359228849411,
0.08817897737026215,
-0.07747265696525574,
-0.21289058029651642,
0.14304955303668976,
-0.5236774682998657,
0.21949805319309235,
-0.7725597620010376,
0.6802714467048645,
-0.09092755615711212,
0.4804498255252838,
0.2600204050540924,
-0.2696918547153473,
0.7186871767044067,
0.14557307958602905,
0.2827758193016052,
0.259319543838501,
-0.9130940437316895,
-0.10568741708993912,
0.06946820020675659,
0.15823784470558167,
0.4293026924133301,
-0.3980411887168884,
-0.21824538707733154,
0.19918443262577057,
-0.07268159836530685,
0.6139891147613525,
0.1094856858253479,
0.07640653848648071,
-0.32001373171806335,
-0.12106850743293762,
0.41634973883628845,
-0.3592017590999603,
0.22613342106342316,
0.6582604646682739,
-0.054170407354831696,
-0.38879281282424927,
-0.3818052411079407,
-0.48691418766975403,
0.319462388753891,
-0.4095376133918762,
-0.03955276310443878,
-0.07422834634780884,
0.7607515454292297,
-0.2966945469379425,
0.4598773419857025,
-0.22400102019309998,
-0.12988200783729553,
0.618364691734314,
-0.48372215032577515,
-0.08589433878660202,
0.01542636752128601,
0.09610920399427414,
0.8957306146621704,
0.5763667225837708,
-0.06486841291189194,
0.6714223623275757,
0.05791739374399185,
0.14455783367156982,
0.20303228497505188,
0.06869184225797653,
0.158216655254364,
0.5742630362510681,
-0.14181402325630188,
0.04006718099117279,
-0.5143315196037292,
-0.34528210759162903,
0.17443044483661652,
-0.35202375054359436,
-0.6785871386528015,
0.007758192252367735,
-1.2139374017715454,
0.1100459173321724,
-0.08676573634147644,
-0.2073616236448288,
-0.5799621343612671,
0.2811835706233978,
0.10469579696655273,
-0.6908742785453796,
0.251608282327652,
0.10927914828062057,
-0.21869106590747833,
0.2132696509361267,
0.2860661447048187,
0.15056534111499786,
-0.20442742109298706,
0.3485338091850281,
0.263430118560791,
0.3310481905937195,
-0.2519407868385315,
0.26914921402931213,
0.12227606773376465,
0.7000607252120972,
-0.32107868790626526,
-0.07552634924650192,
0.19425369799137115,
-0.4405577778816223,
-0.202765554189682,
0.05139129236340523,
0.3482658565044403,
0.2334417849779129,
-0.3149060308933258,
-0.8065522313117981,
-0.6044608354568481,
-0.0002320187195437029,
-0.3150061368942261,
-0.5070405602455139,
0.042489249259233475,
0.11752278357744217,
-0.3506268262863159,
-0.017434068024158478,
-0.2676449418067932,
0.12512536346912384,
-0.2528640031814575,
-0.31051045656204224,
0.06369107216596603,
0.1617037057876587,
-0.006469880696386099,
-0.12182925641536713,
0.6689956188201904,
-0.01383438240736723,
0.30836525559425354,
0.11763134598731995,
-0.3437644839286804,
0.5195444226264954,
0.3440154790878296,
0.01295341458171606,
0.028313234448432922,
0.1384914666414261,
0.04570719972252846,
0.35274621844291687,
-0.38574036955833435,
-0.016376152634620667,
0.2347545325756073,
-0.3118581175804138,
-0.31776824593544006,
-0.07177052646875381,
0.4133046567440033,
0.04138720780611038,
-0.3094046711921692,
-0.24779969453811646,
-0.518052875995636,
-0.34008586406707764,
0.28812915086746216,
-0.07165192812681198,
0.41426804661750793,
0.12856513261795044,
0.24367401003837585,
0.22799265384674072,
0.5407465100288391,
0.22952157258987427,
0.08664585649967194,
-0.4754450023174286,
1.0257952213287354,
-0.4908260107040405,
0.8843910098075867,
0.042603716254234314,
-0.09088070690631866,
0.6994004249572754,
0.25224244594573975,
-0.14467954635620117,
0.0276504997164011,
-0.22885572910308838,
0.6411599516868591,
0.2220505177974701,
-0.6768192052841187,
0.07982370257377625,
-0.44220295548439026,
-0.286620557308197,
-0.15737995505332947,
-0.1560225784778595,
0.41045674681663513,
-0.8281760811805725,
-0.0861206203699112,
-0.23534178733825684,
0.01999126374721527,
0.028321823105216026,
-0.08072610944509506,
0.13023251295089722,
-0.09455406665802002,
-0.23528560996055603,
0.6996336579322815,
-0.7174808382987976,
0.4486556947231293,
0.45368948578834534,
0.10449530184268951,
0.5130497217178345,
0.11704286932945251,
-0.11875808238983154,
0.7807259559631348,
-0.6419925689697266,
0.2111598551273346,
-0.11324851214885712,
0.4725154936313629,
-0.3003314435482025,
0.20062819123268127,
0.61329185962677,
0.012086053378880024,
-0.03325342759490013,
0.1231171265244484,
-0.12390589714050293,
-0.004792536608874798,
0.17176125943660736,
-0.3459157645702362,
0.4855993688106537,
0.5006016492843628,
-0.08533476293087006,
-0.5436476469039917,
-0.10652045905590057,
-0.6674115061759949,
0.17964866757392883,
0.2511895000934601,
-0.11574210971593857,
-0.02098063752055168,
-0.2786969840526581,
0.24710091948509216,
0.12372342497110367,
0.3246127963066101,
-0.7199938297271729,
-0.13462576270103455,
-0.42422980070114136,
-0.6757371425628662,
-0.16059806942939758,
0.09012370556592941,
0.2004145383834839,
-0.08687432110309601,
-0.5253064036369324,
-0.7024295330047607,
-0.5918297171592712,
0.6613541841506958,
0.46799707412719727,
0.09779613465070724,
0.12803979218006134,
-0.7686598896980286,
0.0571446567773819,
-0.10617463290691376,
-0.6360877752304077,
-0.43414461612701416,
0.7029158473014832,
-1.0368149280548096,
-0.22596147656440735,
-0.18359321355819702,
0.6553316712379456,
0.6390938758850098,
-0.18269024789333344,
-0.11845196783542633,
0.12198763340711594,
0.1914641261100769,
-0.3497539460659027,
-0.22464151680469513,
-0.010944426991045475,
-0.3190363943576813,
0.29827821254730225,
-0.24753032624721527,
-0.26941728591918945,
-0.005128263030201197,
0.01719822734594345,
-0.28912273049354553,
0.30197450518608093,
0.8291024565696716,
-0.20509997010231018,
-0.43301862478256226,
-0.028781963512301445,
-0.6457474231719971,
-0.03284541890025139,
-0.27105945348739624,
0.1173686683177948,
-0.2860170304775238,
0.05561733618378639,
-5.922749996185303,
0.1957748979330063,
-0.6194565296173096,
-0.5581241250038147,
-0.21790236234664917,
0.429558664560318,
0.7595248818397522,
-0.022130651399493217,
0.13907228410243988,
-0.1256067007780075,
0.2834385335445404,
0.4585580825805664,
0.25620368123054504,
0.5176976323127747,
-0.1948123276233673,
0.21149465441703796,
-0.11537446826696396,
-0.42742204666137695,
-0.02145666629076004,
-0.4829154908657074,
0.45050954818725586,
0.00292881834320724,
0.007709162775427103,
0.4553026556968689,
0.3987767994403839,
0.6146142482757568,
-0.7637209892272949,
0.08320441097021103,
-0.7773733735084534,
-0.41095149517059326,
-0.26039600372314453,
-0.20797094702720642,
-0.06677325069904327,
-0.03755722939968109,
0.1769225150346756,
0.23557378351688385,
-0.12036452442407608,
0.2867909371852875,
-0.07061199843883514,
-0.5264720320701599,
0.06781011074781418,
-0.07543440163135529,
-0.181950643658638,
-0.42398425936698914,
0.19868579506874084,
-0.021316152065992355,
-0.16498276591300964,
-0.09153897315263748,
-0.30291905999183655,
0.6849951148033142,
0.15355630218982697,
-0.013507530093193054,
0.2530633807182312,
0.8433776497840881,
-0.02082226425409317,
-0.2884581983089447,
0.018026838079094887,
0.05092403665184975,
-0.4769471287727356,
0.17957304418087006,
-0.6681059002876282,
0.12704487144947052,
0.22742411494255066,
-0.8045404553413391,
0.00669907545670867,
-0.03917618468403816,
-0.7058801054954529,
-0.13360127806663513,
0.3540819585323334,
-0.3025248050689697,
-0.630243718624115,
0.165176123380661,
0.2463093250989914,
-0.7544264197349548,
0.15337243676185608,
-0.18558740615844727,
0.08539914339780807,
0.10654040426015854,
-0.27387940883636475,
-0.17988216876983643,
-0.1276499480009079,
-0.3928263783454895,
-0.06372017413377762,
-0.019143834710121155,
0.2637854516506195,
-0.44682157039642334,
-0.12758490443229675,
-0.24044153094291687,
0.009486784227192402,
0.4123940169811249,
0.48477256298065186,
-0.3068253695964813,
0.36018967628479004,
0.0568232387304306,
0.5103229880332947,
0.7617116570472717,
0.15302588045597076,
0.42352816462516785,
0.6203577518463135,
0.12920498847961426,
0.8292247653007507,
-0.23346567153930664,
-0.11351115256547928,
-0.8964012265205383,
-0.4305116534233093,
0.09536408632993698,
-0.26200294494628906,
0.035064928233623505,
0.5690146088600159,
-0.5701782703399658,
0.3245927691459656,
-0.473696768283844,
0.0434153787791729,
-0.4549831748008728,
0.9880682229995728,
-0.60506272315979,
-0.21681596338748932,
0.5978327989578247,
0.414434552192688,
0.048125870525836945,
0.18807832896709442,
0.07700376212596893,
-0.2539689540863037,
0.2655082046985626,
0.18355916440486908,
0.03186088055372238,
0.0975736677646637,
0.22249749302864075,
-0.456590473651886,
0.5707780122756958,
-0.06849189102649689,
0.7005098462104797,
-0.020413821563124657,
-0.5369469523429871,
0.09490204602479935,
-0.21730048954486847,
-0.4263072609901428,
0.1151154637336731,
-0.1539248675107956,
-0.337205708026886,
0.48101407289505005,
-0.09377153217792511,
-0.009847762063145638,
0.5343851447105408,
-0.2810511589050293,
-0.024710671976208687,
-0.00880009401589632,
-0.17447566986083984,
-0.013286163099110126,
0.17557582259178162,
-0.034801602363586426,
-0.2503473162651062,
0.4245081841945648,
-0.3742467164993286,
-0.5768546462059021,
0.5692222118377686,
0.25717803835868835,
0.3322962522506714,
-0.26077187061309814,
-0.5086154937744141,
0.16452902555465698,
-0.13680429756641388,
-0.9555752277374268,
0.038953084498643875,
-0.05970215052366257,
-0.4430266320705414,
-0.33763614296913147,
-0.27594536542892456,
-0.29692527651786804,
0.6318682432174683,
0.14288298785686493,
-0.16738490760326385,
-0.15808676183223724,
0.22478827834129333,
0.31756001710891724,
0.024056607857346535,
-0.5383543372154236,
0.3569847643375397,
0.19228331744670868,
0.25552234053611755,
-0.054790887981653214,
-0.006199497263878584,
-0.28829044103622437,
0.7091161608695984,
0.820916473865509,
0.7019736766815186,
-0.15394456684589386,
-0.3383696377277374,
-0.21653315424919128,
-0.007638635579496622,
0.3279687762260437,
0.025691108778119087,
0.28494492173194885,
-0.09913013875484467,
-0.11675635725259781,
-0.6824139952659607,
-0.13572393357753754,
0.6720107793807983,
-0.15968163311481476,
-0.04234188050031662,
0.23620305955410004,
0.4610726237297058,
-0.3379564881324768,
0.3145278990268707,
0.6469602584838867,
-0.48834550380706787,
0.05929211527109146,
-0.08644922077655792,
-0.07051488012075424,
-0.09708152711391449,
-0.645230770111084,
-0.093581922352314,
-0.12734314799308777,
0.46124958992004395,
-0.3436582386493683,
0.35903823375701904,
0.15944266319274902,
-0.7851585745811462,
-0.6278561353683472,
-0.005615436006337404,
0.08883105218410492,
0.0007924606907181442,
0.03972276300191879,
-0.31794384121894836,
-0.883371889591217,
-0.11295931786298752,
0.3247695565223694,
-0.9215469360351562,
0.006334059406071901,
0.07358002662658691,
0.3112656772136688,
0.03014526702463627,
-0.002260737819597125,
-0.6100243330001831,
-0.1947706788778305,
-0.5292249321937561,
0.0190671868622303,
0.25046101212501526,
0.23548895120620728,
0.33165186643600464,
-0.21131663024425507,
0.4539910852909088,
-0.0927964299917221,
-0.6356016397476196,
0.15374980866909027,
-0.397892028093338,
0.3750062882900238,
-0.42958593368530273,
-0.6723195910453796,
0.3660685420036316,
0.10443031787872314,
-0.3287581503391266,
-0.0618865042924881,
-0.4433893859386444,
1.0202858448028564,
0.28931060433387756,
-0.03142164275050163,
-0.6001644134521484,
0.12182193249464035,
0.3275315761566162,
-0.4067917764186859,
-0.35525578260421753,
0.06118926405906677,
-0.15088222920894623,
0.1031167060136795,
-0.015381930395960808,
-0.16947858035564423,
-0.2724781036376953,
0.17554917931556702,
-0.7794604301452637,
-0.020755942910909653,
0.24904409050941467,
0.3435785472393036,
-0.1451660543680191,
-0.17320875823497772,
0.5540352463722229,
-0.12440504878759384,
0.35409945249557495,
-0.2849525511264801,
0.3592725992202759,
-0.23600143194198608,
-0.34044891595840454,
0.033619921654462814,
0.032011307775974274,
-0.05251669883728027,
-0.5673744082450867,
0.2675471603870392,
0.26778143644332886,
-0.23445628583431244,
-0.10810834169387817,
0.2060202807188034,
-0.07960112392902374,
-0.45936119556427,
0.32540372014045715,
0.1822403520345688,
0.14898794889450073,
0.15327438712120056,
0.5483856797218323,
0.05303298681974411,
-0.36381182074546814,
-0.6768614649772644,
0.15459828078746796,
0.3550861179828644,
-0.6312402486801147,
-0.13254164159297943,
0.18352586030960083,
0.6304625868797302,
0.09873240441083908,
-0.4318290650844574,
0.24936296045780182,
0.6896919012069702,
0.2521420419216156,
0.23097872734069824,
0.6966466903686523,
-0.5466969609260559,
-0.07041551917791367,
-0.3168468177318573,
0.12027209997177124,
0.046712927520275116,
0.16144247353076935,
0.3560870289802551,
0.6240582466125488,
0.50300133228302,
-0.17737361788749695,
-0.05525641888380051,
0.8937073945999146,
-0.1408238261938095,
-0.1359407752752304,
0.1581045389175415,
0.39966994524002075,
0.31823286414146423,
0.10371296107769012,
-0.3016643226146698,
0.7938329577445984,
0.27672621607780457,
0.005506305955350399,
-0.5332854986190796,
-0.4096223711967468,
-0.6201425790786743,
0.5022364258766174,
1.0666630268096924,
0.32187485694885254,
-0.3051317036151886,
-0.07184390723705292,
0.19882233440876007,
0.4834679663181305,
-0.2875257730484009,
-0.0863279476761818,
0.30553358793258667,
-0.1407511681318283,
0.4792840778827667,
-0.3083174228668213,
-0.15194794535636902,
0.01990354061126709,
-0.4881894588470459,
-0.08311638236045837,
-0.14555172622203827,
-0.5188631415367126,
-0.20704281330108643,
0.21133361756801605,
-0.140534907579422,
-0.24506951868534088,
-0.8268903493881226,
0.6412842273712158,
0.02865409478545189,
-0.2379637211561203,
0.32080313563346863,
0.1002611592411995,
-0.07313954085111618,
-0.28411656618118286,
0.5546751022338867,
-0.09040015935897827,
-0.5837310552597046,
0.4218050241470337,
-0.31560078263282776,
-0.5658864378929138,
0.12380967289209366,
-0.15091802179813385,
-0.1755419373512268,
-0.12586624920368195,
-0.7971866726875305,
0.6957141757011414,
0.06352763622999191,
-0.17546701431274414,
-0.4054209887981415,
0.07383313030004501,
-0.16827353835105896,
-0.10616371780633926,
0.6841868758201599,
0.1464165598154068,
0.41336217522621155,
-0.04335106909275055,
-0.04097769409418106,
0.3480873703956604,
-0.14538134634494781,
-0.20809967815876007,
-0.2754712700843811,
-0.10782171785831451,
0.5859220623970032,
0.4497579336166382,
-0.043016303330659866,
-0.11406605690717697,
0.05340233072638512,
0.48693034052848816,
-0.8225817084312439,
0.11262446641921997,
-0.2101966291666031,
-0.21005946397781372,
-0.23575954139232635,
0.0207627285271883,
0.32226115465164185,
0.6815716624259949,
-0.10473962873220444,
0.05272333323955536,
-0.16910924017429352,
0.009448032826185226,
0.712613582611084,
-0.6546905040740967,
-0.3618767559528351,
-0.4789707064628601,
-0.015615365467965603,
-0.7582797408103943,
0.37736761569976807,
-0.4174884855747223,
-0.22125817835330963,
-0.43711382150650024,
0.24052390456199646,
0.2479463368654251,
0.2647572457790375,
0.4325791299343109,
-0.3311719000339508,
0.13882799446582794,
-0.39218854904174805,
0.11090511083602905,
-0.9126188158988953,
0.2703138589859009,
0.1959996074438095,
0.1461460292339325,
0.0643080398440361,
-0.0544469878077507,
-0.31020915508270264,
-0.6707179546356201,
-0.062263838946819305,
0.5202342867851257,
0.6708089709281921,
0.3934473991394043,
0.08196701854467392,
0.012010720558464527,
-0.35266542434692383,
0.09369886666536331,
-0.14932172000408173,
-0.21243637800216675,
0.11336873471736908,
0.13126620650291443,
0.10170498490333557,
-0.043765418231487274,
-0.11223172396421432,
-0.2592015862464905,
-0.04276060685515404,
0.2228718400001526
] |
Advanced Human Nutrition, Second Edition provides an in-depth overview of the human body and details why nutrients are important from a biochemical, physiological, and molecular perspective. Figures help illustrate the content and bring the meaning to life to enhance the reader's understanding. Complex pathways, for example, are presented in a student-friendly fashion, as are diagrams that illustrate metabolism and the molecular functions of nutrients. Multiple elements within the text, such as "Here's Where You Have Been" and "Here's Where You Are Going," help drive home key points from the chapter and provide real-world examples to bring the content to life. Topics covered include: * cell aging, damage and repair systems * human nutrition, digestion, and absorption with relation to organs, exocrine and endocrine functions, histology, and absorptive activities * microflora and satiety/hunger mechanisms * macronutrients during exercise and the role of liquids and sports drinks * prevalent diseases in western cultures such as coronary heart disease, cancer, and osteoporosis An Instructor's Manual, PowerPoint Presentations, and a TestBank are available are free downloads. | [
0.010081704705953598,
0.017454829066991806,
-0.015353236347436905,
0.019510062411427498,
-0.03212980553507805,
-0.03373745456337929,
0.0077919866889715195,
0.008654026314616203,
-0.016108574345707893,
-0.01914469711482525,
-0.02059761807322502,
-0.0015923252794891596,
-0.01472360361367464,
0.002406433690339327,
-0.028615422546863556,
0.01689472235739231,
0.008855849504470825,
0.039467163383960724,
0.002119682962074876,
0.009948979131877422,
0.005276987329125404,
0.003980790730565786,
0.01049751229584217,
0.011618484742939472,
-0.007982328534126282,
0.0014302362687885761,
-0.004295041784644127,
-0.023802833631634712,
0.012256892397999763,
0.015512648969888687,
0.0026732701808214188,
-0.012550434097647667,
0.015429254621267319,
0.011502053588628769,
0.007324028294533491,
0.012281076982617378,
-0.0050543732941150665,
0.016160733997821808,
0.020449891686439514,
-0.0035831318236887455,
-0.0004309841897338629,
-0.0012386646121740341,
0.009305567480623722,
0.02116895280778408,
-0.010676435194909573,
-0.04509248584508896,
-0.0020804456435143948,
-0.017455730587244034,
0.0012040163855999708,
0.016484446823596954,
-0.00950611475855112,
0.007009689696133137,
-0.002579635474830866,
0.010233117267489433,
-0.0061115687713027,
-0.0006880485452711582,
0.019993286579847336,
-0.0013046073727309704,
-0.0031342448201030493,
-0.007335942704230547,
0.028482772409915924,
0.025912471115589142,
-0.004952653311192989,
0.0072997696697711945,
-0.0035851355642080307,
-0.06693724542856216,
-0.009210644289851189,
-0.005385019816458225,
-0.012185761705040932,
0.008739194832742214,
-0.009360861964523792,
0.00930606760084629,
-0.03578898683190346,
0.009166179224848747,
0.002159837866201997,
-0.014656740240752697,
0.005750691518187523,
-0.0003782873973250389,
0.02922719344496727,
0.011877084150910378,
0.01365621667355299,
-0.012443877756595612,
0.001829457702115178,
0.025200601667165756,
0.010612145066261292,
-0.009051814675331116,
-0.012907915748655796,
0.005674443673342466,
0.002675172407180071,
0.0056932177394628525,
0.015414116904139519,
-0.018308449536561966,
-0.027200426906347275,
-0.004414412193000317,
0.0017498312518000603,
0.010652421973645687,
0.003714085789397359,
0.0033263047225773335,
-0.004473582841455936,
-0.010307817719876766,
-0.0008263204945251346,
0.02834169566631317,
0.019460655748844147,
-0.001480746315792203,
-0.014875689521431923,
0.012795775197446346,
-0.01206186693161726,
0.03997364640235901,
-0.0068362983874976635,
0.003762176726013422,
0.009285452775657177,
-0.013158144429326057,
-0.03548075631260872,
-0.0014402528759092093,
-0.025806959718465805,
-0.009466196410357952,
0.002617083489894867,
0.00858275406062603,
0.015617234632372856,
0.03334261476993561,
0.003591720014810562,
-0.008762414567172527,
0.014068491756916046,
0.027121908962726593,
0.0073979878798127174,
-0.002714520785957575,
-0.007741950452327728,
0.01843841001391411,
-0.0039354357868433,
0.004771134816110134,
-0.009776011109352112,
-0.0013418139424175024,
0.023068759590387344,
0.022118065506219864,
-0.006493612192571163,
-0.012076687067747116,
-0.010703069157898426,
0.01442386582493782,
-0.007851287722587585,
-0.009998652152717113,
0.022537581622600555,
0.008752351626753807,
-0.000977284973487258,
0.007171075791120529,
0.04771167039871216,
-0.0016750534996390343,
0.014372529461979866,
0.0018289994914084673,
0.008425809442996979,
0.009213055483996868,
0.022172806784510612,
-0.010678396560251713,
0.0015892761293798685,
-0.015445459634065628,
-0.012165732681751251,
-0.01349153183400631,
-0.012066871859133244,
0.02059042640030384,
-0.0064168027602136135,
0.00763234868645668,
-0.024874720722436905,
-0.013330897316336632,
0.03144724294543266,
0.009263811632990837,
0.006553060375154018,
0.0037457458674907684,
-0.01295971404761076,
-0.014052864164113998,
0.00937739573419094,
0.002914557233452797,
-0.008118455298244953,
0.00654571782797575,
0.003098918590694666,
0.0006984857609495521,
-0.0008316336898133159,
0.002883586101233959,
0.01994560845196247,
0.006757635623216629,
-0.016659261658787727,
0.06600371748209,
0.009906673803925514,
0.034741971641778946,
-0.007236124947667122,
0.0025092456489801407,
0.006706222891807556,
-0.0026384119410067797,
0.04640781506896019,
-0.005287386476993561,
0.00010893656872212887,
0.002111107809469104,
-0.015455782413482666,
0.0025528285186737776,
-0.0013806065544486046,
0.007555855438113213,
0.012432632967829704,
0.003064923919737339,
0.013554459437727928,
0.00046900101006031036,
0.006768709048628807,
0.0027009989134967327,
-0.005037267692387104,
-0.012781156226992607,
0.013366853818297386,
-0.0030053616501390934,
-0.017615608870983124,
0.004232773557305336,
0.00486002117395401,
0.003700213972479105,
-0.0006968348752707243,
0.0273416917771101,
-0.0012324564158916473,
-0.01327880471944809,
-0.010839530266821384,
0.007982317358255386,
-0.02891233190894127,
0.013799548149108887,
-0.013828334398567677,
0.018925709649920464,
-0.022559206932783127,
-0.015623239800333977,
-0.0012248882558196783,
-0.023640483617782593,
-0.01978684961795807,
-0.023679114878177643,
0.008515551686286926,
0.029268356040120125,
-0.000500191526953131,
0.013452727347612381,
0.0028860936872661114,
0.0030593520496040583,
-0.017461776733398438,
0.01455250196158886,
-0.0051327841356396675,
-0.005995822139084339,
0.03162342309951782,
0.005987136159092188,
0.009476691484451294,
-0.016240186989307404,
0.013482961803674698,
-0.004039025865495205,
-0.006902468856424093,
-0.022228188812732697,
0.0035666776821017265,
-0.012347578071057796,
0.023687470704317093,
-0.019492585211992264,
-0.020193060860037804,
-0.007822297513484955,
0.03617329150438309,
0.0005126744508743286,
-0.0000956985168159008,
-0.009382965043187141,
-0.0026288768276572227,
-0.016486756503582,
-0.015245083719491959,
0.011305423453450203,
-0.010340777225792408,
0.018624113872647285,
0.023278694599866867,
0.005445186048746109,
0.005876888521015644,
0.005559207871556282,
-0.01800372637808323,
-0.01331903412938118,
0.022673115134239197,
0.03013591468334198,
0.017054390162229538,
0.010018939152359962,
-0.0006712820613756776,
0.008270753547549248,
0.0039598168805241585,
-0.011648042127490044,
0.008485464379191399,
-0.08069911599159241,
-0.01160643994808197,
-0.01601068675518036,
-0.0049571748822927475,
0.015450950711965561,
0.0016681455308571458,
-0.0001404911745339632,
0.002733288099989295,
-0.016857227310538292,
-0.010740050114691257,
0.020108915865421295,
0.03326874226331711,
-0.009584957733750343,
-0.009962447918951511,
0.010730640962719917,
-0.003872718196362257,
0.018416158854961395,
-0.03520580381155014,
0.001660351175814867,
0.011509053409099579,
0.00832551158964634,
-0.01258213073015213,
-0.008626168593764305,
-0.0077596260234713554,
0.008431353606283665,
-0.016574354842305183,
0.04533878713846207,
-0.00651361420750618,
0.00590423634275794,
0.026859568431973457,
0.01065824180841446,
-0.020708510652184486,
-0.0014051294419914484,
0.006569253280758858,
0.00030715810135006905,
0.02695281431078911,
0.004615010693669319,
0.004131314344704151,
-0.025263536721467972,
0.005875131580978632,
-0.013477085158228874,
0.02726457267999649,
0.003769575385376811,
-0.010084129869937897,
0.004587586037814617,
0.00266784499399364,
0.008706459775567055,
-0.04989321529865265,
0.011879956349730492,
-0.003954138606786728,
0.03381950408220291,
-0.0014156667748466134,
0.028028566390275955,
0.006496130488812923,
-0.005285781342536211,
0.014362981542944908,
0.001203265623189509,
0.00308816647157073,
-0.011857852339744568,
-0.006149166263639927,
0.014616076834499836,
0.00172367412596941,
0.010731027461588383,
0.009452778846025467,
0.021738562732934952,
-0.011503726243972778,
0.0009916166309267282,
0.006095721386373043,
-0.007402376737445593,
0.0025885305367410183,
0.024388805031776428,
0.014210149645805359,
0.01243334636092186,
-0.0022384561598300934,
0.018733970820903778,
-0.020776331424713135,
-0.01601271703839302,
-0.004796711727976799,
-0.009630829095840454,
-0.015957625582814217,
-0.0068300701677799225,
0.002232971368357539,
-0.0031992830336093903,
0.002634515520185232,
-0.008193833753466606,
-0.04146511107683182,
0.004800145979970694,
-0.0006700381636619568,
0.0073075322434306145,
-0.00958637148141861,
0.01929577998816967,
-0.0029462184756994247,
-0.011423764750361443,
0.0021297752391546965,
-0.00046208035200834274,
-0.04166605696082115,
0.026792656630277634,
-0.01926838792860508,
-0.00107856304384768,
0.009617593139410019,
0.0036810790188610554,
0.0045219408348202705,
0.035373009741306305,
-0.018072593957185745,
-0.020288946107029915,
0.00970543920993805,
-0.01651686802506447,
0.01649722084403038,
0.00859873928129673,
-0.013081545941531658,
-0.00826907716691494,
0.010717605240643024,
-0.008937853388488293,
0.0016102648805826902,
0.00724416971206665,
0.007138070650398731,
-0.0433206781744957,
-0.008750226348638535,
0.07213525474071503,
-0.010152030736207962,
0.013950283639132977,
-0.0028225367423146963,
0.005128840450197458,
-0.03389877825975418,
0.007895969785749912,
0.019234295934438705,
-0.02753540314733982,
-0.030535299330949783,
0.010932997800409794,
0.012838318012654781,
-0.01631323993206024,
0.0036313727032393217,
0.0013827946968376637,
-0.009377816691994667,
0.004652043804526329,
0.0072610583156347275,
0.007978432811796665,
0.006359609309583902,
0.004684580955654383,
0.012022425420582294,
-0.01130940206348896,
-0.01530434750020504,
-0.010621430352330208,
-0.047544948756694794,
0.0156190050765872,
-0.011396381072700024,
0.010570242069661617,
0.005086335353553295,
0.015260996297001839,
0.032595306634902954,
-0.0029727350920438766,
-0.001424524001777172,
0.007816008292138577,
0.014069102704524994,
0.018343452364206314,
-0.040681734681129456,
0.007044248282909393,
-0.003724735928699374,
-0.04902761057019234,
-0.011183211579918861,
0.03259316831827164,
0.016610704362392426,
-0.021551374346017838,
0.008643072098493576,
0.0277401190251112,
-0.0048826346173882484,
-0.0032283130567520857,
0.020433982834219933,
-0.0017712987028062344,
-0.006029034499078989,
0.006013606209307909,
-0.025269120931625366,
0.01212502270936966,
0.01397705264389515,
0.018347475677728653,
0.0011098445393145084,
-0.016928451135754585,
-0.017289359122514725,
-0.020286954939365387,
0.005153598263859749,
0.02330164611339569,
-0.03438788652420044,
0.02477111667394638,
-0.015249502845108509,
-0.003845364321023226,
-0.02187189646065235,
0.04276184365153313,
0.001897901762276888,
0.00426400825381279,
0.008501306176185608,
-0.0283522866666317,
-0.0010448023676872253,
-0.001432474935427308,
-0.04579108953475952,
0.036356404423713684,
0.004258650355041027,
-0.00470080878585577,
0.01329005602747202,
0.013484250754117966,
-0.005572550930082798,
0.00935415644198656,
-0.007059007883071899,
0.03663577139377594,
-0.0039059871342033148,
0.0035479385405778885,
-0.07400262355804443,
0.01971794292330742,
-0.006461131386458874,
-0.005055279936641455,
-0.024677451699972153,
-0.01880030706524849,
-0.015376011840999126,
0.009258358739316463,
-0.03274879977107048,
0.003287486033514142,
0.01002834364771843,
-0.006245071068406105,
-0.006176598370075226,
0.00001539662480354309,
0.010222163051366806,
0.007098818197846413,
-0.0001724138855934143,
0.0027487725019454956,
0.006031970493495464,
-0.005434594117105007,
0.01792249083518982,
-0.016257965937256813,
0.015990834683179855,
0.0052774823270738125,
-0.005021298304200172,
-0.08093515038490295,
-0.015478341840207577,
-0.005826718173921108,
0.0070814709179103374,
0.008998749777674675,
-0.0016488460823893547,
0.021341722458600998,
-0.022633645683526993,
-0.0012354145292192698,
-0.014665357768535614,
-0.025386348366737366,
0.010228125378489494,
-0.00828698743134737,
0.0043561579659581184,
-0.0017211849335581064,
-0.004841391928493977,
-0.01304916013032198,
0.00047696358524262905,
0.010801760479807854,
-0.007401215843856335,
-0.013141845352947712,
0.012329010292887688,
-0.011874169111251831,
-0.008434831164777279,
-0.010396653786301613,
-0.010613104328513145,
0.003493168391287327,
0.004019545391201973,
0.009073561057448387,
-0.021180879324674606,
-0.00867247674614191,
0.003874510293826461,
0.006893608253449202,
-0.03148141875863075,
0.0064479392021894455,
-0.016873391345143318,
-0.0038435705937445164,
-0.0035663978196680546,
-0.01674545556306839,
-0.02628069929778576,
-0.005917632952332497,
0.016745273023843765,
0.011008301749825478,
0.012183514423668385,
-0.019744262099266052,
-0.025839202105998993,
0.0038008540868759155,
-0.001076052081771195,
-0.0030259382911026478,
-0.010796021670103073,
0.01238243281841278,
-0.022947201505303383,
0.0012106206268072128,
-0.008347826078534126,
-0.013173497281968594,
0.014554793946444988,
-0.00398318562656641,
-0.004002870060503483,
0.009774181991815567,
0.010762738063931465,
-0.0002501402050256729,
-0.0047965943813323975,
0.0036948269698768854,
0.07107282429933548,
-0.026798922568559647,
0.018926069140434265,
0.003314344212412834,
-0.013820894993841648,
-0.0013724238378927112,
0.004115091636776924,
0.00025789160281419754,
-0.0003383057191967964,
0.0028478512540459633,
0.002837240695953369,
-0.019144516438245773,
-0.011663093231618404,
0.008524347096681595,
0.01118190586566925,
-0.014283519238233566,
-0.023516006767749786,
-0.0008122958242893219,
-0.00940003339201212,
-0.01678294502198696,
0.013783363625407219,
-0.010762080550193787,
-0.0028472901321947575,
-0.002171706408262253,
0.022651486098766327,
-0.015002294443547726,
0.01259627752006054,
0.01852552592754364,
0.014879913069307804,
-0.010773281566798687,
-0.015132315456867218,
0.01823624223470688,
-0.000873984768986702,
0.007162892259657383,
0.03834075480699539,
0.01789756491780281,
-0.01157322060316801,
-0.009909306652843952,
-0.023959843441843987,
-0.036740049719810486,
0.04096606373786926,
-0.0005975323729217052,
0.004125527571886778,
-0.022731583565473557,
0.007267298176884651,
0.01293284073472023,
0.013514654710888863,
-0.0018638282781466842,
-0.001204158179461956,
-0.004520310554653406,
-0.014473604038357735,
0.010013192892074585,
-0.02009352669119835,
0.013440231792628765,
-0.014952121302485466,
-0.016988519579172134,
0.009242911823093891,
0.010733707807958126,
0.013207465410232544,
-0.02393418923020363,
0.013795990496873856,
-0.020061612129211426,
-0.01732116937637329,
-0.006647815927863121,
-0.00221808347851038,
-0.006722538266330957,
-0.014130123890936375,
-0.007971812039613724,
0.0029427174013108015,
0.013808345422148705,
-0.017076771706342697,
-0.023753471672534943,
0.0025690479669719934,
0.0022078226320445538,
0.01965891197323799,
-0.019104301929473877,
0.004277806729078293,
0.0018689918797463179,
0.02506755106151104,
-0.011191658675670624,
-0.0038420932833105326,
0.022315915673971176,
-0.0020100795663893223,
-0.010025478899478912,
-0.014820614829659462,
-0.0085371732711792,
0.018930695950984955,
-0.0002626077039167285,
-0.004018824547529221,
0.013383273035287857,
0.021844498813152313,
0.0038107894361019135,
0.012259868904948235,
0.00921655260026455,
0.00013906374806538224,
0.03317427635192871,
0.019198335707187653,
0.007692781277000904,
-0.024241231381893158,
-0.001404669601470232,
-0.0015931325033307076,
-0.000806532334536314,
0.02004595473408699,
-0.014473664574325085,
-0.009138762950897217,
-0.007619368843734264,
0.027287190780043602,
-0.002571819582954049,
0.005169815383851528,
0.011771023273468018,
-0.00026465021073818207,
-0.001019712770357728,
-0.019161492586135864,
0.023132644593715668,
-0.02076030895113945,
-0.009236238896846771,
-0.011789393611252308,
0.018923820927739143,
-0.01362705323845148,
-0.010001178830862045,
-0.014181429520249367,
-0.005425467621535063,
-0.01030275970697403,
0.008581278845667839,
-0.0021475795656442642,
-0.02550683170557022,
-0.006739335134625435,
0.0409979410469532,
0.014439699240028858,
0.007365429308265448,
0.019725127145648003,
-0.018004652112722397,
0.020541483536362648,
0.0021187099628150463,
0.01725728064775467,
0.03004838339984417,
-0.02825966663658619,
0.011217978782951832,
-0.0033729514107108116,
-0.0011751726269721985,
0.019897866994142532,
-0.015480810776352882,
-0.008842833340168,
0.0312967374920845,
0.006896176375448704,
-0.007815093733370304,
-0.005965931341052055,
0.0027322208043187857,
0.007574641145765781,
0.011335404589772224,
-0.010594744235277176,
0.0020975631196051836,
-0.016976244747638702,
-0.013543283566832542,
-0.026905300095677376,
0.02187662199139595,
-0.006077329162508249,
0.04465864971280098,
-0.0013915710151195526,
-0.00048624537885189056,
0.01889009401202202,
0.0026524525601416826,
0.01700185239315033,
0.013100245967507362,
-0.03121391497552395,
0.00343204103410244,
0.0046227723360061646,
0.022617749869823456,
0.0021239137277007103,
0.0021641033235937357,
0.01809566095471382,
0.01659553311765194,
-0.011905238032341003,
0.026211529970169067,
-0.02892237901687622,
-0.021725434809923172,
-0.009702933952212334,
0.019987571984529495,
0.005144473165273666,
-0.004266759846359491,
0.0019014410208910704,
0.006078254897147417,
0.0010920275235548615,
-0.019331302493810654,
-0.004923600237816572,
-0.0018196732271462679,
-0.013100868090987206,
0.029813654720783234,
-0.009418206289410591,
-0.02760075218975544,
-0.015306070446968079,
-0.002315729856491089,
-0.020791176706552505,
-0.008320474065840244,
-0.023752465844154358,
-0.020357120782136917,
-0.007619813084602356,
-0.04138124734163284,
0.013670631684362888,
0.0033970680087804794,
-0.001942021306604147,
-0.015360962599515915
] | [
0.3056090176105499,
0.010867663659155369,
-0.1172901839017868,
-0.11611247062683105,
0.16143161058425903,
0.039171040058135986,
-0.09286157041788101,
0.06384280323982239,
0.42136409878730774,
-0.5752845406532288,
-0.40824365615844727,
0.33742159605026245,
0.19855402410030365,
-0.09059770405292511,
0.12276948988437653,
0.06845701485872269,
0.4929940104484558,
0.156340554356575,
-0.2389426976442337,
-0.0008426494314335287,
-0.36913907527923584,
0.017636919394135475,
0.4750635027885437,
0.023411152884364128,
0.1674196422100067,
0.20100009441375732,
0.31583330035209656,
0.46826571226119995,
-0.6975639462471008,
-0.4783904552459717,
-0.5149158835411072,
0.06762462854385376,
-0.22283725440502167,
-0.3095071315765381,
-0.07624243199825287,
0.02530684880912304,
0.02043132111430168,
-0.0900183618068695,
0.07368151843547821,
-0.27648428082466125,
-0.4276760518550873,
0.46147018671035767,
-0.3158978223800659,
0.6428400874137878,
-0.12085837125778198,
-0.0014218256110325456,
-1.6504429578781128,
-0.22829388082027435,
-1.194976568222046,
0.11181899905204773,
-0.07020380347967148,
0.02434524893760681,
0.5912908911705017,
0.16762875020503998,
-0.2712319791316986,
0.5104477405548096,
-0.5653027892112732,
-0.03602612763643265,
-0.11793059855699539,
-0.4183303713798523,
0.39652809500694275,
0.5465741157531738,
-0.27933013439178467,
0.4309007227420807,
0.04330776259303093,
-0.23086827993392944,
-0.029809774830937386,
-0.22067178785800934,
-0.080894336104393,
-0.22603842616081238,
0.2816976308822632,
-0.26389846205711365,
-0.6307721734046936,
0.6707544326782227,
0.03461368381977081,
-0.3378005623817444,
-0.17110443115234375,
0.06439049541950226,
-0.17633220553398132,
-0.4702799320220947,
-0.2888198494911194,
0.3050377666950226,
0.2336537390947342,
-0.38084015250205994,
0.4522457420825958,
0.3275412917137146,
-0.12334509938955307,
0.29485318064689636,
-0.11575595289468765,
0.11041583120822906,
-0.3650481402873993,
-0.4454759955406189,
0.14377593994140625,
0.35962334275245667,
0.5947128534317017,
-0.6540358066558838,
0.3459877371788025,
-0.23673659563064575,
0.4052145183086395,
0.0766678974032402,
-0.3479210138320923,
-0.22314485907554626,
0.5813648700714111,
-0.037883348762989044,
-0.1290970891714096,
-0.2786332666873932,
-0.21091356873512268,
-0.7100124955177307,
-0.038724202662706375,
0.539179265499115,
-0.5000874996185303,
0.22603969275951385,
-0.23209737241268158,
-0.24518956243991852,
-0.170978382229805,
0.4313661754131317,
0.018269700929522514,
-0.23363274335861206,
-0.8659632802009583,
0.09985338896512985,
-0.09153234213590622,
0.4845888018608093,
0.3670870065689087,
0.19578303396701813,
0.3107958137989044,
-0.018723735585808754,
0.2847883105278015,
0.28719159960746765,
-0.3052937388420105,
0.5944850444793701,
0.30203092098236084,
-0.18153418600559235,
0.08851900696754456,
0.047027330845594406,
-0.3874952495098114,
-0.35297730565071106,
0.44688233733177185,
-0.013780830428004265,
0.1835610717535019,
0.2234818935394287,
-0.2744731903076172,
-0.41472986340522766,
-0.122197724878788,
-0.5705819725990295,
0.08687679469585419,
-0.44713959097862244,
-0.02717587910592556,
-0.07470786571502686,
-0.3216175436973572,
0.04940899461507797,
0.45439425110816956,
-0.09328148514032364,
-0.3174784779548645,
-0.1594831943511963,
0.2013801485300064,
0.9233031868934631,
0.04078398272395134,
0.4882144629955292,
-0.3891042470932007,
-0.05135517567396164,
0.541617751121521,
0.35986292362213135,
-0.21326343715190887,
-0.45862483978271484,
0.19562311470508575,
-0.4027206301689148,
0.19162747263908386,
0.33102479577064514,
0.4648312032222748,
-0.04809877276420593,
-0.22506630420684814,
-0.42431262135505676,
0.10093741863965988,
-0.2640531063079834,
-0.6012322306632996,
0.4200923442840576,
0.46615034341812134,
0.4295552372932434,
0.11016427725553513,
-0.28598108887672424,
-0.4133921265602112,
-0.3115888237953186,
0.13326066732406616,
-0.798893392086029,
0.3511117100715637,
-0.7272562980651855,
0.4650016725063324,
-0.1326567679643631,
0.031030382961034775,
0.350097119808197,
-0.5376453995704651,
-0.5691518187522888,
0.07917042821645737,
-0.7054343819618225,
0.8944510221481323,
-0.18584509193897247,
-0.14454606175422668,
1.1901521682739258,
-0.3702290654182434,
-0.1297481656074524,
-0.20564620196819305,
0.555087149143219,
0.23932825028896332,
-0.054189588874578476,
-0.5437260270118713,
-0.24037465453147888,
0.1483277827501297,
-0.30703356862068176,
0.35842859745025635,
0.2573642134666443,
0.15120598673820496,
0.21415559947490692,
-0.017585042864084244,
0.02027015946805477,
0.11084006726741791,
0.14930833876132965,
0.2202988564968109,
0.5053324699401855,
0.09400484710931778,
-0.3098464906215668,
0.888209879398346,
0.12598557770252228,
0.5313628911972046,
0.22004300355911255,
-0.20707003772258759,
0.36612361669540405,
0.8725755214691162,
0.6581672430038452,
0.46523284912109375,
-0.13888972997665405,
0.4829508364200592,
-0.06690891832113266,
0.4181288480758667,
-0.5500941276550293,
-0.12903355062007904,
-0.022177059203386307,
0.12875844538211823,
-0.2640977203845978,
-0.020091718062758446,
-0.4155951738357544,
0.06523095071315765,
0.07642355561256409,
-0.29903164505958557,
0.10299330949783325,
0.25951874256134033,
-0.42352786660194397,
0.0038437950424849987,
0.7206900715827942,
-0.42500442266464233,
-0.48493894934654236,
0.045362357050180435,
0.11499443650245667,
0.3106427788734436,
0.08949130028486252,
-0.1126926839351654,
0.12060429155826569,
-0.5701290369033813,
-0.23472510278224945,
0.8194054365158081,
0.07636018842458725,
-0.0035930892918258905,
0.02401505969464779,
0.01305662002414465,
0.18226292729377747,
-0.0955345407128334,
-0.24748247861862183,
-0.06792223453521729,
-0.9070663452148438,
0.3538578152656555,
0.6592549681663513,
0.3670228123664856,
0.39121270179748535,
-0.7755045294761658,
0.1606673151254654,
-0.14617645740509033,
-1.0582507848739624,
0.8382290601730347,
0.023870058357715607,
-0.06312950700521469,
-0.2286195009946823,
0.00460107671096921,
0.5215693712234497,
0.6585438251495361,
-0.20511315762996674,
-0.24698200821876526,
-0.6480964422225952,
0.25900566577911377,
-0.3487931787967682,
-0.3505789041519165,
0.6094751954078674,
0.19919049739837646,
0.24798943102359772,
-0.6393844485282898,
-0.47887730598449707,
0.7249374985694885,
0.19249708950519562,
-0.07618213444948196,
-0.08941205590963364,
0.4820587933063507,
-0.29255351424217224,
0.23268362879753113,
-0.18209724128246307,
0.10391658544540405,
0.33577215671539307,
0.3082934319972992,
-0.5940976738929749,
-0.11843249201774597,
-0.09238234907388687,
-6.109148979187012,
-0.23771819472312927,
-0.5356036424636841,
-0.0818776860833168,
-0.15433745086193085,
-0.22786548733711243,
0.40633317828178406,
-0.11126326024532318,
0.18850907683372498,
-0.2803739011287689,
0.23971202969551086,
0.4238293766975403,
0.23872920870780945,
0.5730257630348206,
-0.1677074134349823,
0.48517292737960815,
0.19803960621356964,
0.08028612285852432,
-0.33582302927970886,
0.48402559757232666,
0.27870455384254456,
-0.8002097606658936,
0.11767447739839554,
0.9034827947616577,
0.17804034054279327,
-0.2785092294216156,
-1.0016024112701416,
0.6704823970794678,
0.08292678743600845,
-0.40709057450294495,
0.3892034590244293,
-0.49937909841537476,
-0.0617690347135067,
-0.3157195746898651,
0.29445022344589233,
0.31544673442840576,
-0.0902789756655693,
0.23721180856227875,
0.4584243893623352,
-0.14017973840236664,
0.41287556290626526,
0.7217061519622803,
0.3073560893535614,
-0.29434460401535034,
0.3452188968658447,
-0.2706582546234131,
-0.39305827021598816,
0.2381245344877243,
-0.01382663007825613,
0.7728502750396729,
-0.06485265493392944,
0.21136122941970825,
0.399601012468338,
0.2913047671318054,
-0.19784457981586456,
-0.2164977639913559,
0.22125789523124695,
0.12111105024814606,
-0.07783183455467224,
-0.05822353437542915,
0.03649916127324104,
-0.7019633054733276,
-0.10143059492111206,
-0.6438297033309937,
-0.11309962719678879,
0.3335491716861725,
-0.3793737292289734,
0.026925407350063324,
-0.4648038446903229,
0.3745419979095459,
-0.7005640268325806,
0.5353758931159973,
0.04343647137284279,
-0.7427607178688049,
0.41747504472732544,
-0.19426444172859192,
0.016469089314341545,
0.029952822253108025,
-0.12173887342214584,
-0.06356819719076157,
0.11884407699108124,
-0.1469540148973465,
-0.2262977808713913,
0.5209124684333801,
0.45103856921195984,
-0.7509344816207886,
0.04642767831683159,
-0.4771355390548706,
-0.565940260887146,
0.18631210923194885,
0.5830300450325012,
-0.431629478931427,
0.06821444630622864,
-0.11820520460605621,
0.222343310713768,
0.11802062392234802,
-0.16948847472667694,
0.04229994863271713,
0.7218418717384338,
-0.552667498588562,
0.4425739049911499,
-0.109551802277565,
0.042747318744659424,
-0.44058555364608765,
-0.05921322852373123,
-0.22633829712867737,
-0.5634053349494934,
0.2555220425128937,
0.6321596503257751,
-0.677533745765686,
-0.36107611656188965,
0.08774882555007935,
-0.5751875042915344,
-0.09241002798080444,
0.24341259896755219,
0.4334239363670349,
-0.18844345211982727,
-0.1898355484008789,
0.4562237560749054,
0.2374430000782013,
-0.48130589723587036,
-0.07506568729877472,
0.01678243838250637,
0.000851568125654012,
0.453083336353302,
-0.3620089590549469,
0.4067561626434326,
0.6571141481399536,
0.04472356662154198,
0.1305372267961502,
0.3937550485134125,
0.13699504733085632,
0.09638883918523788,
0.07479425519704819,
0.06527473777532578,
-0.4682827591896057,
0.06203078478574753,
0.27507147192955017,
-0.37136736512184143,
-0.3691524565219879,
-0.13909095525741577,
-0.058354925364255905,
0.1412389725446701,
-0.03266062214970589,
0.374962717294693,
-0.07176557928323746,
-0.16030095517635345,
0.3215406835079193,
-0.26097962260246277,
0.3336361050605774,
0.3251006305217743,
0.058175235986709595,
0.09699027985334396,
-0.011046921834349632,
-0.27120500802993774,
-0.09541855752468109,
0.21356350183486938,
0.23509277403354645,
-0.1066887229681015,
-0.3394356966018677,
0.6714528203010559,
-0.5412662625312805,
-0.7167775630950928,
0.15321189165115356,
-0.09083805978298187,
0.4073691666126251,
-0.028910253196954727,
-0.8476894497871399,
-0.17298360168933868,
0.022169096395373344,
0.47083088755607605,
-0.2358061671257019,
0.04868846759200096,
-0.3012165129184723,
0.14698860049247742,
-0.22050128877162933,
-0.03145431727170944,
-0.049187444150447845,
0.16388404369354248,
-0.32080650329589844,
0.06161123886704445,
-1.1004117727279663,
0.35893622040748596,
0.03683475777506828,
0.5326553583145142,
-0.27233201265335083,
0.048805441707372665,
-0.11703720688819885,
-0.2800588309764862,
-0.7947111129760742,
-0.02543255314230919,
0.016759512946009636,
0.4389934837818146,
-0.16365304589271545,
-0.12219405174255371,
-0.2748918831348419,
0.5596197843551636,
0.04457739740610123,
-0.14171059429645538,
-0.06144029274582863,
-0.2456003874540329,
0.4464384913444519,
-0.44084295630455017,
0.5613227486610413,
0.4823920428752899,
-0.23437145352363586,
-0.1144561618566513,
-0.05522974953055382,
0.03986421599984169,
0.01722096838057041,
-0.38117754459381104,
-0.0050292653031647205,
0.25130495429039,
-0.22512155771255493,
-0.4307146966457367,
0.35488423705101013,
0.08026985824108124,
-0.3867720067501068,
-0.573302149772644,
0.20405252277851105,
0.29532888531684875,
-0.018336070701479912,
-0.7794076800346375,
0.07894890010356903,
-0.10476856678724289,
0.09395425766706467,
1.0554825067520142,
-0.5413486361503601,
-0.11650998890399933,
-0.3481478989124298,
-0.3112301826477051,
0.29803645610809326,
0.27522915601730347,
0.16115547716617584,
-0.03074614144861698,
-0.1697942465543747,
-0.38116198778152466,
0.20116646587848663,
0.13717913627624512,
0.42484933137893677,
-0.2413959950208664,
0.39828231930732727,
-0.11670832335948944,
-0.3207681179046631,
0.014368108473718166,
0.6429004669189453,
-0.0167558453977108,
-0.4747212529182434,
-0.6561494469642639,
0.03364857658743858,
0.30855613946914673,
-0.11591514945030212,
0.11406398564577103,
-0.1679898202419281,
0.15259914100170135,
-0.3710794448852539,
-0.3582412004470825,
-0.12685911357402802,
-0.0637107640504837,
0.012026193551719189,
0.22911401093006134,
0.09547699987888336,
-0.5933058857917786,
-0.013983447104692459,
0.09513252228498459,
-0.14193493127822876,
-0.007614127825945616,
-0.6359249949455261,
0.0450674332678318,
-0.2783437967300415,
0.10619353502988815,
0.017561569809913635,
-0.17887279391288757,
0.28285351395606995,
0.18281620740890503,
-0.03261611610651016,
-0.03692901134490967,
-0.6151578426361084,
-0.1322566568851471,
-0.34215301275253296,
-0.17898671329021454,
-0.1262119710445404,
0.09467507898807526,
-0.08875324577093124,
0.48442813754081726,
-0.5032050013542175,
0.2062653750181198,
0.028176555410027504,
-0.01636924222111702,
0.1381159871816635,
-0.23508884012699127,
-0.019263528287410736,
-0.4751705527305603,
-0.608340859413147,
-0.12933781743049622,
0.5053308010101318,
0.7299012541770935,
-0.1409769356250763,
-0.10353729873895645,
-0.704388439655304,
0.47109055519104004,
0.2727961242198944,
0.5703321099281311,
-0.3299141526222229,
0.05889424309134483,
0.6675065755844116,
0.25371235609054565,
0.011532907374203205,
-0.6419147253036499,
0.4002036154270172,
0.37350010871887207,
-0.26907339692115784,
0.3996555805206299,
0.711277425289154,
0.06823786348104477,
0.19620966911315918,
-0.3122131824493408,
-0.6412714123725891,
0.21030977368354797,
0.15519240498542786,
-0.18483272194862366,
0.3541373014450073,
0.39966443181037903,
0.056472986936569214,
-0.3493533432483673,
0.28922873735427856,
-0.04683710262179375,
-0.1553996205329895,
-0.3118855059146881,
0.14007329940795898,
0.3999936878681183,
1.0386980772018433,
-0.0066284737549722195,
0.28336453437805176,
-0.025050371885299683,
0.4577292501926422,
0.50014728307724,
-0.13091488182544708,
0.25559350848197937,
0.1050342470407486,
0.02161952666938305,
0.6394098401069641,
-0.05507669597864151,
0.0016850600950419903,
-0.30146124958992004,
0.42577657103538513,
-0.17045757174491882,
0.3418619930744171,
-0.3687891960144043,
0.2953987121582031,
0.03931482136249542,
0.051521215587854385,
-0.3918937146663666,
-0.024393411353230476,
-0.19599834084510803,
-0.18587826192378998,
0.3136953115463257,
-0.5083622336387634,
-0.3385355472564697,
0.29675090312957764,
0.11496753245592117,
0.5967314839363098,
-0.1296038180589676,
-0.4035085141658783,
-0.14220412075519562,
0.05169261246919632,
0.11614792793989182,
-0.3616566061973572,
0.24455837905406952,
0.28872692584991455,
-0.5341230630874634,
0.37707585096359253,
-0.5472027659416199,
-0.3622715473175049,
0.30448222160339355,
-0.2009003907442093,
0.3275384306907654,
-0.06404570490121841,
0.1969980150461197,
0.6016935110092163,
-0.15177732706069946,
-0.2877556383609772,
-0.3959912955760956,
-0.5593053102493286,
0.09912392497062683,
-0.03511496260762215,
0.09374203532934189,
0.3710983395576477,
-0.6272560954093933,
-0.07253154367208481,
-0.13523714244365692,
-0.8334727883338928,
-0.03928986191749573,
-0.20992258191108704,
0.1351144015789032,
-0.08469447493553162,
0.10796582698822021,
0.8478016257286072,
0.4391494691371918,
-0.24771350622177124,
-0.07830503582954407,
-0.05333664268255234,
0.11249273270368576,
0.4019439220428467,
-0.080202616751194,
0.42296499013900757,
-0.4561237692832947,
-0.20620101690292358,
-0.3820103108882904,
0.1832129955291748,
0.5533595085144043,
0.008599174208939075,
-0.11069507896900177,
-0.12970711290836334,
0.6426622867584229,
0.3213562071323395,
-0.2433796226978302,
-0.018971150740981102,
0.3332754671573639,
0.15424473583698273,
-0.09557872265577316,
-0.3663543164730072,
0.1095021665096283,
0.6088468432426453,
-0.4099542796611786,
0.11445123702287674,
-0.07553450018167496,
0.692136287689209,
-0.5809778571128845,
0.22391389310359955,
0.24806375801563263,
-0.3947497308254242,
-0.7680811882019043,
0.342067688703537,
-0.2921050190925598,
-0.11935336887836456,
0.14413374662399292,
0.42678284645080566,
0.1589416265487671,
-0.24528436362743378,
-0.5176529288291931,
0.07866468280553818,
0.23604553937911987,
0.6143226027488708,
-0.11388766020536423,
0.48742154240608215,
0.12189317494630814,
-0.34505242109298706,
-0.7562890648841858,
0.2791347801685333,
-0.09674535691738129,
0.2806601822376251,
-0.2610273063182831,
0.06654957681894302,
-0.46098294854164124,
-0.021776286885142326,
-0.02074594795703888,
-0.2067883014678955,
0.27310895919799805,
-0.24822257459163666
] |
Introduction. Methods To Study Endothelium-Dependent Responses. Endothelium-Derived Relaxing Factor. Physiological Actions. Other Relaxing Substances Released By the Endothelium. Production of Contracting Agents. Local Regulation of Endothelium-Dependent Responses. Neurohumoral Regulation. Heterogeneity and Chronic Modulation. Disease. Therapeutic Implications. References. Subject Index. | [
0.015273045748472214,
0.0006974575226195157,
-0.013848657719790936,
0.011575169861316681,
0.004401130136102438,
-0.004755822010338306,
0.008749819360673428,
-0.00037211482413113117,
-0.012945392169058323,
-0.022422995418310165,
-0.004911614581942558,
0.01981227658689022,
-0.01642192155122757,
0.013778471387922764,
0.014135143719613552,
0.028354980051517487,
-0.03519999235868454,
0.0054526859894394875,
0.0025973916053771973,
-0.0008885771967470646,
-0.00032966502476483583,
0.0032338728196918964,
0.008665116503834724,
-0.014761264435946941,
-0.006285936571657658,
-0.0010487878462299705,
0.003252357244491577,
0.013838346116244793,
0.012399365194141865,
0.0159671138972044,
0.007688131183385849,
-0.0045639402233064175,
0.0131045151501894,
-0.016368312761187553,
0.0021133581176400185,
-0.0018260148353874683,
-0.004787052050232887,
0.015508987009525299,
0.026502171531319618,
-0.0043216608464717865,
-0.0045378622598946095,
-0.006945217493921518,
0.007856668904423714,
-0.04049307480454445,
-0.005664435680955648,
-0.02192475087940693,
-0.00599919306114316,
0.012807680293917656,
0.00027622931520454586,
0.0025206434074789286,
-0.006485742051154375,
-0.009134313091635704,
-0.0028199059888720512,
-0.0055221207439899445,
-0.005270170047879219,
-0.008098636753857136,
0.017922013998031616,
0.009159577079117298,
-0.0003425688773859292,
-0.013402382843196392,
-0.020576229318976402,
0.016555503010749817,
0.0065781534649431705,
-0.03721501678228378,
-0.01984204538166523,
-0.06705011427402496,
0.01187285128980875,
-0.006195428315550089,
0.0016659031389281154,
0.00003859731805277988,
0.01929307170212269,
0.012880642898380756,
-0.00022721511777490377,
-0.001793893170543015,
0.015410317108035088,
0.0016641514375805855,
-0.021358422935009003,
0.012216378003358841,
-0.012197010219097137,
-0.03168625012040138,
0.024681290611624718,
-0.010050510987639427,
-0.017269983887672424,
0.017094887793064117,
-0.00006568321259692311,
0.012124746106564999,
-0.016624795272946358,
0.0032066283747553825,
0.006303439382463694,
0.017006216570734978,
-0.021763289347290993,
0.0055259820073843,
-0.011122874915599823,
0.011651198379695415,
-0.002061279257759452,
-0.0041683129966259,
-0.018214328214526176,
-0.0173180028796196,
0.018898211419582367,
0.01904330588877201,
-0.024012355133891106,
0.02090674452483654,
0.015845032408833504,
0.019650593400001526,
0.0036132175009697676,
0.003387069795280695,
0.012371116317808628,
0.031824201345443726,
-0.008709595538675785,
0.008818374946713448,
0.006489085964858532,
0.018293241038918495,
-0.011464297771453857,
-0.011921646073460579,
0.03314214572310448,
-0.019586853682994843,
-0.0021496734116226435,
0.015054331161081791,
0.013984101824462414,
0.008512421511113644,
0.02160768210887909,
0.02913774736225605,
0.012384013272821903,
-0.028911052271723747,
0.007201540749520063,
0.010940746404230595,
-0.021816108375787735,
0.0034015339333564043,
0.0006043287576176226,
0.005241898354142904,
-0.0035960578825324774,
-0.006663880310952663,
0.02873878739774227,
-0.014764972031116486,
-0.004670396912842989,
-0.006458309944719076,
0.009120790287852287,
-0.03654040768742561,
-0.01002309750765562,
-0.018198415637016296,
0.01503420528024435,
0.0047093708999454975,
-0.0031615730840712786,
0.007249182090163231,
-0.006067616865038872,
-0.007280522491782904,
0.02572455070912838,
-0.021971305832266808,
-0.010660148225724697,
-0.02807285636663437,
0.02966848947107792,
-0.014905398711562157,
0.005790578201413155,
-0.006336838006973267,
0.017133060842752457,
-0.012341567315161228,
-0.013380930759012699,
-0.02978411130607128,
-0.01598254032433033,
0.011089733801782131,
-0.02387162484228611,
0.0012444895692169666,
0.01802714727818966,
0.0067971874959766865,
-0.011665111407637596,
0.005096547771245241,
0.0015344095882028341,
-0.0018582803895696998,
0.0031872750259935856,
0.0038933500181883574,
-0.008541880175471306,
0.016753926873207092,
0.02848208323121071,
0.004274369217455387,
0.002964041894301772,
0.006480574607849121,
0.00623124185949564,
0.004897073842585087,
-0.008747310377657413,
0.06664040684700012,
0.019542811438441277,
-0.020474538207054138,
0.004609328228980303,
0.00903000496327877,
0.010374085046350956,
-0.011642688885331154,
0.03048219531774521,
-0.0023995637893676758,
0.030564697459340096,
0.0035339510068297386,
0.006241446826606989,
-0.0004583006666507572,
-0.016570398584008217,
-0.020357323810458183,
0.008461568504571915,
0.00199797167442739,
0.006097541190683842,
-0.005606210790574551,
-0.015946852043271065,
0.01865912787616253,
0.011877852492034435,
-0.02246210351586342,
0.013955865055322647,
-0.02342853881418705,
0.012328533455729485,
0.01275451760739088,
-0.005797021556645632,
0.0012924892362207174,
0.01717095635831356,
0.037072308361530304,
0.0023014429025352,
-0.01172805018723011,
-0.0011399730574339628,
0.0003867761988658458,
-0.013132262974977493,
0.009547119028866291,
-0.020493758842349052,
0.013697300106287003,
-0.01120717916637659,
-0.01302429847419262,
-0.0044965846464037895,
0.02922733686864376,
-0.013268275186419487,
-0.012303299270570278,
0.016487421467900276,
-0.014046095311641693,
0.012728297151625156,
0.014535807073116302,
-0.009314578957855701,
-0.012562023475766182,
0.000922810286283493,
-0.01138900127261877,
-0.010331086814403534,
0.01794862002134323,
0.01484422106295824,
0.019532963633537292,
0.009495561011135578,
-0.010757001116871834,
0.0064840978011488914,
-0.00013119367940817028,
-0.009558849036693573,
-0.012143109925091267,
0.030545592308044434,
-0.0019289897754788399,
0.01967936009168625,
0.015984579920768738,
0.014106499031186104,
-0.006912797689437866,
0.014955824241042137,
-0.0002523426082916558,
0.004686311352998018,
-0.004177059046924114,
-0.02790045365691185,
-0.013953727670013905,
0.028036324307322502,
0.002869931049644947,
-0.004817954730242491,
-0.015434925444424152,
0.024366172030568123,
-0.013552648015320301,
-0.008190494030714035,
0.0044827512465417385,
0.013242744840681553,
-0.01785965822637081,
-0.003596128663048148,
-0.006096604745835066,
0.005985263269394636,
0.004199258983135223,
0.01398925855755806,
0.010209823027253151,
0.005498128477483988,
-0.006735018454492092,
-0.0002520663838367909,
-0.08197430521249771,
-0.011037754826247692,
0.0020949591416865587,
0.011675938032567501,
0.005399084649980068,
-0.018349038437008858,
0.00203081127256155,
0.000501331640407443,
-0.011059438809752464,
-0.0409458726644516,
0.015321050770580769,
0.009453992359340191,
-0.015895627439022064,
0.014353470876812935,
-0.007071265485137701,
0.005194697063416243,
0.007477279286831617,
-0.025044778361916542,
-0.005240455735474825,
-0.010428786277770996,
0.005751383490860462,
-0.007087789010256529,
-0.01742701232433319,
0.01595848985016346,
0.024314500391483307,
-0.001759110833518207,
-0.004617383703589439,
0.011862684972584248,
-0.009688280522823334,
0.010151811875402927,
-0.015194952487945557,
0.00917812529951334,
-0.005103275645524263,
-0.025306792929768562,
0.014891166239976883,
-0.0005741611821576953,
0.005116887856274843,
-0.027379469946026802,
-0.013527882285416126,
0.0010268340120092034,
0.015342704020440578,
0.011795981787145138,
-0.006518777925521135,
-0.011237413622438908,
0.006885193753987551,
-0.010652259923517704,
0.03357098624110222,
-0.012892813421785831,
0.003507837187498808,
0.01918909326195717,
-0.015313255600631237,
0.0015498989960178733,
0.025699160993099213,
0.02005484327673912,
-0.01108593586832285,
-0.008123023435473442,
-0.0063558719120919704,
0.006075912155210972,
-0.005931466817855835,
-0.009525640867650509,
0.002625303342938423,
-0.0026943753473460674,
0.007761544082313776,
0.015505610033869743,
0.008452153764665127,
-0.010575275868177414,
0.003056414658203721,
0.0028677014634013176,
-0.013017239049077034,
0.01280390564352274,
-0.006885576993227005,
-0.026643510907888412,
-0.014601738192141056,
0.000620280799921602,
-0.020866069942712784,
-0.01596742309629917,
-0.012991812080144882,
-0.000535902043338865,
-0.004448818042874336,
-0.002904829801991582,
-0.006760720629245043,
-0.003016164293512702,
0.006088207941502333,
0.014233382418751717,
-0.025648333132267,
-0.02773364633321762,
0.003717595711350441,
0.004176275804638863,
0.012926245108246803,
-0.010827995836734772,
-0.008335940539836884,
0.015418664552271366,
0.028243141248822212,
0.005452039185911417,
-0.0002461942203808576,
-0.007591725327074528,
0.03362565115094185,
-0.007526237517595291,
0.0042722043581306934,
0.00797488447278738,
-0.0035337889567017555,
0.00480493251234293,
-0.002369919326156378,
-0.0162806436419487,
-0.03187471255660057,
0.012988061644136906,
-0.002486147917807102,
-0.008022542111575603,
0.004339197184890509,
-0.003898314666002989,
-0.007298068143427372,
-0.0067822374403476715,
-0.010725675150752068,
0.026946786791086197,
0.004863315727561712,
0.02513762377202511,
0.00737897539511323,
0.023610703647136688,
0.07272256910800934,
0.015076112933456898,
-0.002300519961863756,
-0.009443091228604317,
-0.013163216412067413,
0.0009153495193459094,
0.017498433589935303,
-0.004209289327263832,
0.007120465859770775,
-0.013290496543049812,
0.01185627467930317,
-0.004301161505281925,
0.03383580967783928,
0.015910783782601357,
-0.010673785582184792,
-0.022975461557507515,
0.01018491294234991,
0.016252364963293076,
0.02030022256076336,
-0.0030681092757731676,
0.0091402567923069,
-0.023265507072210312,
-0.01129886880517006,
-0.001364395604468882,
0.00045940279960632324,
-0.025621816515922546,
-0.026735253632068634,
-0.01433673594146967,
0.0012997963931411505,
0.008265798911452293,
0.002373482333496213,
-0.0446028932929039,
-0.009398744441568851,
-0.011901908554136753,
0.03143646940588951,
0.022523632273077965,
0.017961936071515083,
-0.01617581583559513,
0.005237404257059097,
0.011576219461858273,
0.003621811978518963,
-0.011854619719088078,
0.012134704738855362,
0.005317322444170713,
0.004238309804350138,
0.011142099276185036,
0.010643469169735909,
-0.0003188565606251359,
-0.00662747910246253,
0.021369926631450653,
-0.019797900691628456,
0.010595171712338924,
0.0062913428992033005,
0.010479710064828396,
-0.004090118687599897,
0.010373272001743317,
0.006615718826651573,
-0.0026226320769637823,
-0.00007336614362429827,
0.05010329186916351,
-0.004140981938689947,
0.0018068612553179264,
0.004037525504827499,
-0.012232482433319092,
0.009645898826420307,
-0.0158541239798069,
-0.015874875709414482,
-0.02007344923913479,
-0.03092777542769909,
0.012099235318601131,
-0.00045475916704162955,
0.013867625035345554,
-0.0336427204310894,
0.007099259179085493,
-0.0004717244009952992,
0.003262953832745552,
0.009728371165692806,
0.011079484596848488,
0.012907414697110653,
0.0027828856837004423,
-0.00947756227105856,
0.006258953362703323,
-0.003246953710913658,
0.003871193155646324,
-0.009200320579111576,
0.007075562607496977,
-0.004836088977754116,
-0.07486558705568314,
0.0014898814260959625,
0.028954045847058296,
-0.004006120376288891,
0.016946056857705116,
-0.005814222153276205,
-0.011135734617710114,
0.004065635148435831,
0.004716044291853905,
-0.010445185005664825,
-0.011708851903676987,
0.005227705929428339,
-0.012763052247464657,
0.004616645630449057,
0.008335034362971783,
0.010834707878530025,
0.023799560964107513,
0.0020492805633693933,
-0.005143305286765099,
-0.004702303092926741,
0.006403119303286076,
-0.023387925699353218,
-0.01841571554541588,
0.002106240950524807,
0.0017663964536041021,
-0.08129706233739853,
-0.001145143760368228,
-0.008284290321171284,
-0.0024979764129966497,
-0.013916241005063057,
-0.006121156271547079,
-0.0026376182213425636,
0.00016053352737799287,
0.02352919988334179,
-0.018494701012969017,
0.000823264301288873,
-0.004451153799891472,
-0.007378921378403902,
-0.0019262185087427497,
-0.0037103029899299145,
-0.003874792717397213,
0.01202327385544777,
-0.03352796286344528,
0.004607862792909145,
-0.03352583199739456,
-0.002652687719091773,
-0.01790916919708252,
-0.0112405801191926,
-0.013731592334806919,
-0.002103352453559637,
0.00401693070307374,
0.004595846403390169,
0.0043292962945997715,
0.010843868367373943,
-0.01440415158867836,
0.021241726353764534,
-0.011004684492945671,
-0.008048821240663528,
-0.005933798383921385,
-0.00739653967320919,
-0.011483961716294289,
-0.01590564474463463,
-0.0007401859038509429,
-0.009339000098407269,
0.00005254770439933054,
-0.0009228077833540738,
0.009639836847782135,
0.008903635665774345,
0.0011558488477021456,
-0.03277859836816788,
-0.016563324257731438,
0.005023479461669922,
-0.00013082509394735098,
0.005447160452604294,
0.024994993582367897,
-0.001085879746824503,
-0.009170940145850182,
0.012558945454657078,
0.027691669762134552,
-0.01374554168432951,
0.012011484242975712,
0.0004682073777075857,
0.00004234854714013636,
-0.014743976294994354,
-0.003428874770179391,
-0.011280068196356297,
-0.011460083536803722,
-0.007022125646471977,
0.07181344926357269,
0.012285761535167694,
0.006287050433456898,
-0.01590413972735405,
0.005739386659115553,
0.002005073009058833,
0.010261104442179203,
-0.006828365381807089,
0.0023474565241485834,
0.0007602075929753482,
-0.010794288478791714,
0.0006815552478656173,
0.01215296145528555,
0.010906251147389412,
-0.006171741057187319,
0.017295220866799355,
0.035008762031793594,
0.039238475263118744,
0.0009284444386139512,
0.015349317342042923,
0.003056909190490842,
-0.007498402614146471,
-0.024157926440238953,
0.007728054653853178,
0.0032284827902913094,
-0.017081303521990776,
0.012078040279448032,
-0.008773598819971085,
0.0023373248986899853,
0.006996948271989822,
-0.002411467954516411,
-0.018101384863257408,
-0.009715817868709564,
-0.006267848424613476,
0.014179307036101818,
0.009689132682979107,
-0.0005987925105728209,
0.00409232871606946,
-0.02577565610408783,
-0.009015170857310295,
-0.00788949616253376,
0.013434511609375477,
0.00000996777271211613,
-0.0020277376752346754,
-0.002444065874442458,
0.012630113400518894,
-0.016482969745993614,
-0.004529193975031376,
-0.005650848150253296,
-0.004916185047477484,
0.029431676492094994,
0.009722007438540459,
0.022830506786704063,
0.0014856010675430298,
0.01375321764498949,
0.014501444064080715,
-0.012970252893865108,
0.016232671216130257,
-0.035630401223897934,
-0.022510936483740807,
-0.002260074019432068,
-0.026241285726428032,
0.02122548408806324,
-0.009482784196734428,
-0.009803802706301212,
-0.013297623954713345,
0.004029184114187956,
-0.01172680500894785,
-0.019215265288949013,
0.01041147019714117,
-0.018538393080234528,
-0.0038359982427209616,
-0.0006837323307991028,
0.0007533523603342474,
0.0074678403325378895,
-0.008314775303006172,
-0.0014103584690019488,
0.002849574899300933,
0.01610759273171425,
0.004929732996970415,
-0.01887139119207859,
0.010718063451349735,
-0.004432062152773142,
0.031946565955877304,
-0.005740426946431398,
-0.02793780155479908,
0.014498621225357056,
0.014269758015871048,
0.0020910443272441626,
0.011778954416513443,
0.009709330275654793,
-0.0022308221086859703,
0.00990609172731638,
0.01705087721347809,
0.0007503948290832341,
0.03394441306591034,
0.013708624988794327,
0.008166465908288956,
0.011130644008517265,
-0.007949748076498508,
-0.004802114795893431,
0.012410260736942291,
-0.006828282494097948,
-0.02175605110824108,
0.01393162366002798,
-0.004916011355817318,
-0.023662138730287552,
-0.02277972549200058,
0.008180270902812481,
0.0003658168716356158,
0.01530425064265728,
0.016443459317088127,
-0.005846092943102121,
-0.023206563666462898,
0.00526609318330884,
-0.006238151341676712,
-0.015098737552762032,
-0.042349886149168015,
0.017517175525426865,
-0.011942241340875626,
0.003190641524270177,
-0.014560400508344173,
-0.017809392884373665,
0.01044074073433876,
-0.030527345836162567,
-0.002663574879989028,
-0.011531694792211056,
0.018585463985800743,
-0.006205313839018345,
-0.013553965836763382,
0.00617686752229929,
0.007946116849780083,
-0.0005084226722829044,
-0.011373074725270271,
0.0009677939815446734,
-0.007349318824708462,
-0.012107987888157368,
0.010476566851139069,
-0.0036308830603957176,
-0.015365684404969215,
-0.0016080300556495786,
-0.006960841361433268,
-0.001936525572091341,
-0.010311944410204887,
0.0070154666900634766,
-0.022275041788816452,
0.027251245453953743,
0.031115606427192688,
0.009931662119925022,
0.010487393476068974,
-0.014820251613855362,
-0.020908795297145844,
0.014813894405961037,
-0.006913553923368454,
0.023037267848849297,
0.03565257415175438,
0.0041875774040818214,
-0.024160195142030716,
-0.008114502765238285,
0.0007713738596066833,
0.015206058509647846,
-0.02232135646045208,
0.007054247427731752,
-0.0002715935406740755,
0.006607066839933395,
-0.031351689249277115,
0.016825444996356964,
0.011576795019209385,
-0.017451856285333633,
-0.016125386580824852,
0.018091635778546333,
0.005014985799789429,
-0.0004816307919099927,
0.008033697493374348,
-0.024154057726264,
-0.0020224160980433226,
-0.015478466637432575,
0.008507464081048965,
-0.021447036415338516,
0.009556233882904053,
-0.005748365074396133,
-0.007890399545431137,
-0.014665300957858562,
-0.0018300442025065422,
-0.006581208668649197,
-0.011928132735192776,
-0.0071151377633214,
0.008741883561015129,
-0.00593010475859046,
-0.002209811005741358,
-0.031809691339731216,
-0.001909565064124763,
-0.015508085489273071,
0.00354939722456038,
-0.014735558070242405,
-0.007601723074913025,
0.002852689241990447,
-0.002532097976654768,
0.008298350498080254,
-0.0013445861404761672,
0.0010826756479218602,
-0.018223505467176437
] | [
0.04996713995933533,
-0.019667349755764008,
0.03657539188861847,
-0.052173737436532974,
-0.15454663336277008,
0.30199864506721497,
0.053150806576013565,
-0.6141324639320374,
-0.04673297703266144,
-0.7181733846664429,
-0.09879342466592789,
0.34908995032310486,
-0.4765813648700714,
0.09868445247411728,
0.1103590652346611,
0.5387848019599915,
0.12339875102043152,
-0.03573334962129593,
-0.28309881687164307,
-0.36228251457214355,
-0.18157958984375,
0.2517351508140564,
0.4162387251853943,
-0.21880699694156647,
0.31612977385520935,
0.12249621003866196,
0.31677737832069397,
0.058002352714538574,
-0.021735643967986107,
-0.08992687612771988,
0.004427765961736441,
0.3675558269023895,
-0.5945284366607666,
-0.25245702266693115,
-0.4551277756690979,
-0.3849722146987915,
0.03217817470431328,
-0.04262532666325569,
0.23598581552505493,
-0.314888060092926,
-0.29820913076400757,
0.16658665239810944,
-0.15655085444450378,
0.28726494312286377,
-0.013041788712143898,
-0.4667322635650635,
-1.823136806488037,
0.15771792829036713,
-0.44195249676704407,
-0.08443017303943634,
0.24721993505954742,
0.06070332229137421,
0.7199221253395081,
0.13668371737003326,
-0.01294725388288498,
0.06960821896791458,
-0.27600160241127014,
-0.4949122965335846,
0.1760980188846588,
-0.5543329119682312,
0.09380479156970978,
0.5872581601142883,
-0.05850079283118248,
0.23249036073684692,
0.23769977688789368,
0.5647240281105042,
-0.04191660135984421,
-0.2352294921875,
0.3334338665008545,
-0.23388619720935822,
-0.00822103675454855,
-0.22142180800437927,
0.05291961878538132,
0.2060462087392807,
0.3151845633983612,
-0.17286314070224762,
0.24506472051143646,
-0.23955652117729187,
0.2541932463645935,
-0.18182727694511414,
0.12491647154092789,
0.05136844888329506,
0.03301631286740303,
-0.7025831341743469,
0.5696437358856201,
0.40192586183547974,
-0.32171666622161865,
0.35260042548179626,
-0.7494837045669556,
-0.26544883847236633,
-0.04719404876232147,
-0.3486335575580597,
0.5151485204696655,
0.0942017063498497,
0.5219689011573792,
0.058804936707019806,
0.11487412452697754,
-0.12296697497367859,
-0.009632126428186893,
0.5611011385917664,
-0.13632215559482574,
-0.01633654348552227,
-0.21512584388256073,
-0.40796589851379395,
-0.2776939868927002,
-0.1421431303024292,
-0.2520507872104645,
-0.865779459476471,
-0.6678338646888733,
0.34734705090522766,
-0.4696051776409149,
-0.31332898139953613,
0.24147452414035797,
-0.3202233612537384,
-0.04504574090242386,
0.3977983295917511,
0.019439777359366417,
-0.014361000619828701,
-0.25067558884620667,
0.6258251070976257,
-0.1180296242237091,
0.733048677444458,
-0.13741567730903625,
0.19548143446445465,
-0.04671960696578026,
-0.07654045522212982,
0.4208870828151703,
0.33652135729789734,
-0.4153859317302704,
0.38223332166671753,
-0.08644452691078186,
0.5746718645095825,
-0.6257070899009705,
0.3080655336380005,
-0.19088366627693176,
-0.601399838924408,
0.11016451567411423,
0.04976502060890198,
0.047895919531583786,
0.10242534428834915,
0.010979116894304752,
-0.32573428750038147,
-0.34686994552612305,
-0.2789197862148285,
-0.07619922608137131,
-0.7731788158416748,
-0.11179003864526749,
-0.2619820833206177,
0.10644247382879257,
-0.012639099732041359,
0.03948122635483742,
0.1942535787820816,
-0.5797579884529114,
0.3468835949897766,
-0.27408185601234436,
0.5290325880050659,
0.2706455886363983,
0.016925273463129997,
-0.11118420958518982,
0.028865838423371315,
0.480171799659729,
-0.16614602506160736,
-0.6135098338127136,
-0.16064083576202393,
0.558067262172699,
-0.2207711637020111,
-0.14955195784568787,
0.5885463953018188,
0.4892154633998871,
-0.31260472536087036,
-0.3146330714225769,
-0.08570937812328339,
-0.18297302722930908,
-0.3370926082134247,
-0.03509807959198952,
0.29190054535865784,
0.3823137581348419,
0.4088159501552582,
0.2528851330280304,
0.2279137820005417,
-0.39153948426246643,
-0.3455255925655365,
-0.26778700947761536,
-0.8724741339683533,
0.3014746904373169,
-0.09938974678516388,
0.4842674732208252,
-0.26088476181030273,
0.28113511204719543,
0.25001639127731323,
0.10680035501718521,
0.07807596027851105,
0.37352561950683594,
-0.6459594964981079,
1.3949236869812012,
-0.24236878752708435,
-0.14057742059230804,
1.2889996767044067,
-0.09688609838485718,
-0.254537433385849,
-0.0502961166203022,
0.42064332962036133,
0.41303062438964844,
-0.03259632736444473,
-0.2437819242477417,
0.20456808805465698,
0.0168991107493639,
-0.398438960313797,
-0.07578463852405548,
0.44112256169319153,
0.5746812224388123,
-0.006962789688259363,
0.1828519105911255,
-0.6296346783638,
0.5403081774711609,
-0.38083136081695557,
0.19367706775665283,
0.48718932271003723,
-0.11572913825511932,
0.22188441455364227,
0.6980742812156677,
0.23228274285793304,
0.6168603301048279,
1.0234787464141846,
-0.21371163427829742,
0.3189675807952881,
0.5986749529838562,
0.08011414110660553,
0.5269951224327087,
-0.4218370318412781,
0.21529431641101837,
-0.5885416269302368,
0.42865094542503357,
-0.4180316925048828,
-0.07988283783197403,
0.49618566036224365,
-0.2256830483675003,
-0.0900447815656662,
-0.30042049288749695,
-0.33848440647125244,
-0.04413437470793724,
0.42916372418403625,
-0.6953624486923218,
0.16345708072185516,
0.18473365902900696,
-0.1330132633447647,
-0.28749868273735046,
0.47392475605010986,
-0.6442651152610779,
0.040561601519584656,
0.04561658948659897,
0.5271610617637634,
0.2853316068649292,
-0.5475596189498901,
0.19267523288726807,
0.24836255609989166,
-0.6831885576248169,
-0.05950817093253136,
0.33657047152519226,
0.14805325865745544,
-0.4999838173389435,
0.10298717021942139,
0.16946150362491608,
0.11396641284227371,
-0.10338250547647476,
-0.2568829357624054,
-0.5881708860397339,
-0.7210735082626343,
0.30775922536849976,
0.5925455689430237,
0.6449825763702393,
0.2094510793685913,
-0.5623279809951782,
0.10346370935440063,
-0.10195773839950562,
-0.26799532771110535,
0.3622058629989624,
0.7424176931381226,
-0.4984835088253021,
-0.44598087668418884,
-0.01926785334944725,
0.1757906973361969,
0.8132776618003845,
-0.009822515770792961,
-0.5478014945983887,
-0.48068225383758545,
-0.009508972987532616,
-0.4208900034427643,
-0.348676472902298,
-0.007880214601755142,
0.03254678472876549,
0.7491980791091919,
-0.2397512048482895,
-0.3642096519470215,
0.295219361782074,
0.5738101005554199,
-0.4993475377559662,
0.5865021347999573,
0.4273945093154907,
-0.1906750202178955,
-0.19754409790039062,
0.31892433762550354,
0.014419425278902054,
0.1865236908197403,
0.1796390265226364,
-0.4069863557815552,
-0.4874876141548157,
0.08742932975292206,
-6.108039379119873,
-0.3912004232406616,
0.15107207000255585,
0.29259562492370605,
0.07774238288402557,
0.18589453399181366,
1.3505687713623047,
-0.17115063965320587,
-0.03566158935427666,
-0.009914039634168148,
0.31793496012687683,
0.4783848524093628,
0.15852153301239014,
0.29524436593055725,
0.0613824799656868,
0.3759511113166809,
-0.013799318112432957,
-0.0009726327261887491,
0.02628783881664276,
0.34345829486846924,
0.04992588236927986,
-0.29083502292633057,
0.28389233350753784,
0.41538161039352417,
0.23819328844547272,
-0.012603155337274075,
-1.0790762901306152,
0.4973558485507965,
-0.0997922345995903,
0.24726130068302155,
0.3583051264286041,
-0.3792571723461151,
-0.014492228627204895,
-0.49334803223609924,
0.306571900844574,
0.32000136375427246,
0.2718300521373749,
0.3503386378288269,
0.44725939631462097,
-0.4508228898048401,
-0.05739298090338707,
0.34408390522003174,
-0.20093238353729248,
0.14032624661922455,
0.1333315074443817,
-0.15640994906425476,
0.2252025455236435,
0.14029842615127563,
-0.49280449748039246,
0.7976357340812683,
-0.08262026309967041,
-0.08898007124662399,
0.7071943879127502,
0.28564685583114624,
0.12205241620540619,
-0.523521363735199,
-0.03783149644732475,
0.010970521718263626,
-0.5435663461685181,
0.229169100522995,
0.00769363297149539,
-0.3372576832771301,
0.019954144954681396,
-0.5907958745956421,
-0.3961728811264038,
0.2278643250465393,
-1.012470006942749,
-0.698296070098877,
0.06260842829942703,
0.21366392076015472,
-0.19521190226078033,
0.24563924968242645,
0.35019752383232117,
-0.6179637312889099,
-0.05077717453241348,
-0.35451143980026245,
-0.12334334850311279,
-0.16500559449195862,
0.26871466636657715,
-0.12007425725460052,
-0.16441869735717773,
0.0713442787528038,
-0.331604540348053,
0.6700296401977539,
0.25749459862709045,
0.12886075675487518,
-0.2375735342502594,
-0.5390780568122864,
-0.9278002977371216,
-0.17287079989910126,
0.08720212429761887,
0.07728181034326553,
0.00758990366011858,
0.405227392911911,
0.3672230541706085,
0.33553430438041687,
0.4962978661060333,
-0.06345468759536743,
0.27622178196907043,
-0.3726295232772827,
1.1288150548934937,
-0.0593351311981678,
-0.2633276879787445,
-0.6969410181045532,
0.21541373431682587,
0.03651164844632149,
-0.8641918301582336,
0.3620873689651489,
0.8241355419158936,
-0.9723761081695557,
0.005181413609534502,
0.12772531807422638,
-0.3851860761642456,
-0.0017832915764302015,
0.00775944022461772,
0.09439308196306229,
-0.3905048370361328,
-0.2768319249153137,
0.6818249225616455,
-0.16752514243125916,
-0.11017301678657532,
0.5320391058921814,
0.03043399564921856,
0.03289802372455597,
0.06207328662276268,
0.032114267349243164,
0.07692437618970871,
0.23061181604862213,
-0.6031360030174255,
-0.16375182569026947,
0.31080976128578186,
0.5355411171913147,
-0.3652099668979645,
0.0025999394711107016,
0.29179319739341736,
-0.3582287132740021,
-0.48621487617492676,
0.43568485975265503,
0.10148253291845322,
-0.35349395871162415,
0.20322060585021973,
-0.5539175868034363,
-0.22568602859973907,
-0.09072650969028473,
0.3531472384929657,
0.09035635739564896,
-0.26158425211906433,
0.023895783349871635,
-0.1556837260723114,
0.17398695647716522,
0.4728354215621948,
-0.13288342952728271,
0.06603733450174332,
-0.24502740800380707,
-0.4393419921398163,
-0.0020065319258719683,
0.19177629053592682,
-0.007013319525867701,
0.2758702039718628,
-0.445692777633667,
0.6149890422821045,
-0.21174359321594238,
-0.6841436624526978,
-0.059136226773262024,
-0.18792541325092316,
-0.10844109952449799,
-0.5896624326705933,
-0.40465083718299866,
-0.3198879063129425,
0.002515029162168503,
0.026602134108543396,
-0.14392384886741638,
-0.33970534801483154,
-0.3772300183773041,
-0.1971224993467331,
0.1779215931892395,
-0.268973171710968,
0.0953313410282135,
-0.3386044204235077,
-0.09666050970554352,
0.4767834544181824,
-1.0499860048294067,
-0.11792192608118057,
0.27376294136047363,
0.6770621538162231,
0.0015038455603644252,
0.3220720589160919,
-0.2973178029060364,
0.026711314916610718,
-0.13429223001003265,
0.2590883672237396,
0.43956640362739563,
0.400326669216156,
-0.3482034206390381,
-0.14279769361019135,
-0.41750043630599976,
0.22096054255962372,
0.33765512704849243,
-0.18313992023468018,
-0.6171576380729675,
0.3096870481967926,
0.5330777764320374,
-0.27380308508872986,
0.644327700138092,
0.24477823078632355,
0.014056953601539135,
-0.07073831558227539,
-0.3981504738330841,
-0.10835237056016922,
-0.08901980519294739,
-0.03844267129898071,
-0.6203078031539917,
0.059727657586336136,
0.2131684273481369,
-0.436873197555542,
0.25343990325927734,
-0.09408916532993317,
-0.3424341380596161,
-0.37311089038848877,
0.4014793634414673,
0.6077274084091187,
-0.1635933369398117,
-0.4394581913948059,
-0.0461740605533123,
-0.07333599030971527,
-0.13594509661197662,
0.3461388647556305,
-0.5596987009048462,
0.13774512708187103,
0.11880405247211456,
-0.5287123322486877,
-0.07035832852125168,
0.18427260220050812,
-0.2691883146762848,
-0.7285401821136475,
0.028145788237452507,
-0.7242617607116699,
0.18900927901268005,
0.036269769072532654,
0.20859815180301666,
-0.09055715799331665,
0.5209811925888062,
-0.36737778782844543,
-0.44357675313949585,
-0.019929517060518265,
0.25028762221336365,
0.35954320430755615,
-0.345596581697464,
-0.3228664696216583,
0.05526307225227356,
0.15645906329154968,
0.013342794962227345,
-0.18038593232631683,
0.29148679971694946,
0.46864867210388184,
-0.019076036289334297,
-0.2078336775302887,
0.23005063831806183,
0.17615488171577454,
0.26794442534446716,
-0.12670278549194336,
0.23242653906345367,
-0.4092189371585846,
-0.13759315013885498,
0.29509586095809937,
-0.002657553879544139,
0.05083389952778816,
-0.4241076111793518,
0.41931211948394775,
-0.0843874141573906,
-0.4173256754875183,
-0.16141758859157562,
0.26369211077690125,
0.3863537311553955,
0.12737853825092316,
0.14200465381145477,
-0.15636883676052094,
0.05719142407178879,
-0.10502161830663681,
0.16445067524909973,
-0.30254799127578735,
-0.4759408235549927,
0.2878168225288391,
-0.07428494095802307,
0.5644809603691101,
-0.6869441270828247,
0.1145377904176712,
0.12555767595767975,
-0.04397660493850708,
-0.2251325249671936,
0.00887913815677166,
-0.011129610240459442,
-0.8131594061851501,
-0.16914381086826324,
-0.0023288484662771225,
0.6622444987297058,
-0.24575591087341309,
-0.1534791886806488,
0.10228721052408218,
0.0467885285615921,
-0.2422170639038086,
0.44768840074539185,
0.43355870246887207,
-0.19854789972305298,
0.11464031785726547,
0.34441789984703064,
0.28361546993255615,
-0.023792577907443047,
-0.26479196548461914,
0.002017323626205325,
0.148311585187912,
-0.3754151463508606,
0.2518247961997986,
0.3423070013523102,
-0.1259753704071045,
-0.046748191118240356,
-0.050783175975084305,
-0.3954829275608063,
0.4667758345603943,
0.49721401929855347,
0.04492846876382828,
0.6600391268730164,
0.5612267851829529,
-0.3814108073711395,
-0.41520851850509644,
0.5025177597999573,
-0.3642626404762268,
0.2104899138212204,
-0.0957801342010498,
0.19445350766181946,
0.8621888160705566,
0.6174365878105164,
-0.11268506944179535,
0.11146838217973709,
0.3316880166530609,
0.3090074062347412,
0.652182936668396,
-0.18392151594161987,
-0.3667745590209961,
-0.2324610948562622,
0.5377269983291626,
0.5024482607841492,
-0.21145424246788025,
-0.3942301571369171,
0.15662679076194763,
0.24091482162475586,
-0.0131705142557621,
0.3700089156627655,
-0.1746836006641388,
0.33329659700393677,
0.3419506549835205,
-0.2086264044046402,
-0.23525439202785492,
-0.1774509996175766,
-0.5530765652656555,
-0.10199256986379623,
0.5688686966896057,
-0.46253877878189087,
-0.3259108066558838,
-0.019573625177145004,
0.27452942728996277,
0.5470577478408813,
-0.30278486013412476,
0.021478088572621346,
-0.04234306886792183,
0.5388613939285278,
0.6345126628875732,
0.2523757517337799,
0.07709427922964096,
-0.002696478273719549,
-0.23787769675254822,
-0.2717724144458771,
0.005709575954824686,
-0.15012389421463013,
0.14740099012851715,
-0.6990625262260437,
0.18493656814098358,
0.1364285945892334,
0.20114310085773468,
0.40005555748939514,
0.115263931453228,
-0.0013993396423757076,
-0.24142420291900635,
-0.8352311253547668,
0.2353426069021225,
-0.12530706822872162,
-0.42566922307014465,
0.13765527307987213,
-0.47991833090782166,
-0.02635333314538002,
-0.04060875624418259,
-0.8373709321022034,
-0.03071052022278309,
0.17858849465847015,
-0.19024650752544403,
-0.12087128311395645,
-0.21201740205287933,
0.5342793464660645,
0.07525119930505753,
-0.10612214356660843,
-0.3882251977920532,
0.27738526463508606,
-0.08291123807430267,
0.024759046733379364,
0.23627111315727234,
0.6208584904670715,
-0.452737957239151,
0.4930186867713928,
-0.25247254967689514,
0.011033540591597557,
0.5890632271766663,
0.4832282066345215,
-0.30340638756752014,
-0.13754798471927643,
0.134881392121315,
0.5591254830360413,
0.09477785974740982,
-0.17591533064842224,
-0.2591541111469269,
-0.15871553122997284,
0.011471698060631752,
-0.2331598699092865,
0.5401791930198669,
0.06672950088977814,
-0.5656688809394836,
-0.326315313577652,
0.1526668518781662,
0.42172935605049133,
0.04410318657755852,
0.5144234895706177,
-0.04738180339336395,
-0.5167635083198547,
-0.6040060520172119,
0.5706680417060852,
-0.17867517471313477,
0.31489619612693787,
-0.3530331552028656,
0.1705223023891449,
0.04289465770125389,
0.23531639575958252,
-0.23194998502731323,
-0.16287878155708313,
0.42452752590179443,
0.45066675543785095,
-0.20488786697387695,
0.39690959453582764,
-0.020685316994786263,
-0.4240705072879791,
-0.42113232612609863,
0.17248055338859558,
0.054706696420907974,
-0.47606781125068665,
-0.18859750032424927,
-0.34799396991729736,
-0.36870232224464417,
-0.060142360627651215,
-0.3190293312072754,
-0.7030308842658997,
-0.1503174751996994,
0.04934028163552284
] |
Abstract Objective Our previous 6-month, randomized study demonstrated the beneficial effect of a vegetarian (V) compared to a conventional diet (C) with similar caloric restriction on cardiovascular risk factors for patients with type 2 diabetes (T2D), namely increased insulin sensitivity, reduced body weight, reduced volume of visceral and subcutaneous fat, decreased LDL-cholesterol and improved oxidative stress markers and chosen adipokines. We conducted post-trial monitoring to determine whether the improved outcomes persisted 1 year after the end of the study. Methods 62 subjects with T2D who completed the study were asked to come for a 1-year follow-up to measure weight, waist circumference, HbA1c and blood lipids. No attempts were made to maintain their previously assigned diets. Results 44 patients (71%) attended the post-trial monitoring. Hypoglycemic agents were increased by 14% in V and by 26% in C; insulin therapy was introduced in 5% in V and in 13% in C one year after the end of the intervention. Neither weight nor waist circumference changed significantly in either group. HbA1c increased ( p ≤ 0.05) similarly in both groups (+0.49 ± 1.04% in V vs. +0.42 ± 0.8% in C). Blood lipids did not change in either group. Conclusion One year after the end of the intervention, the positive effects of a vegetarian diet on cardiovascular risk factors compared to a conventional diet were partially maintained. | [
-0.001861843280494213,
0.02113915979862213,
-0.01161419041454792,
0.009956207126379013,
0.008523969911038876,
-0.0010748370550572872,
0.006991948001086712,
0.01505662314593792,
-0.008203576318919659,
-0.018694939091801643,
-0.01912624016404152,
0.0065962085500359535,
-0.010914134792983532,
0.02057352289557457,
0.019146114587783813,
-0.014397220686078072,
-0.006844955962151289,
-0.019264057278633118,
0.0031517327297478914,
0.025595098733901978,
0.003621479496359825,
0.005158394109457731,
0.00915979128330946,
0.00870868656784296,
-0.007393273524940014,
0.007637659087777138,
0.04752251133322716,
-0.029266072437167168,
-0.004202596843242645,
0.0036192189436405897,
0.004853724502027035,
-0.006746112369000912,
-0.010375901125371456,
-0.0037347879260778427,
-0.0030470495112240314,
0.011252771131694317,
0.005662998184561729,
0.022493217140436172,
0.0020734211429953575,
-0.003916226327419281,
-0.008401535451412201,
-0.004919608123600483,
0.004253366496413946,
-0.011777249164879322,
-0.005932641215622425,
0.00565766217187047,
-0.0020763888023793697,
0.0010493351146578789,
-0.010233237408101559,
0.009933221153914928,
-0.0024340508971363306,
0.0010267844190821052,
-0.010358234867453575,
0.015797682106494904,
-0.004974378272891045,
-0.011972304433584213,
0.015662476420402527,
-0.016176972538232803,
-0.018978577107191086,
0.02375379577279091,
0.007545109838247299,
-0.009202307090163231,
-0.001096431165933609,
-0.013749322853982449,
0.011636177077889442,
-0.06711435317993164,
0.0038388893008232117,
-0.01391695998609066,
0.005263133905827999,
-0.003950783982872963,
0.005849349778145552,
0.01056405808776617,
0.020572124049067497,
0.008584162220358849,
-0.013812242075800896,
-0.008371951058506966,
0.023111920803785324,
0.028934191912412643,
0.011096609756350517,
-0.0067269462160766125,
-0.010569116100668907,
0.0020528575405478477,
-0.018734261393547058,
0.020578408613801003,
0.011822903528809547,
0.003859093179926276,
-0.022808825597167015,
-0.015434620901942253,
-0.005489288829267025,
0.00729338638484478,
0.004690565634518862,
-0.028244871646165848,
0.02333557978272438,
-0.009041151031851768,
0.012058967724442482,
-0.0060960473492741585,
0.0014096889644861221,
0.006798811722546816,
0.023465445265173912,
-0.021693266928195953,
-0.007634373381733894,
-0.008867132477462292,
0.014540999196469784,
-0.0010441916529089212,
-0.0017095692455768585,
0.010740190744400024,
0.006687849760055542,
0.014883127994835377,
-0.016639627516269684,
0.004781917668879032,
0.0027230768464505672,
0.04614853486418724,
0.030131418257951736,
-0.002334762364625931,
0.015955038368701935,
0.009015647694468498,
0.005718677304685116,
-0.014741212129592896,
0.004132790956646204,
-0.008762642741203308,
0.018475424498319626,
-0.010476937517523766,
0.0026780138723552227,
0.014685047790408134,
0.003592040156945586,
-0.018614821135997772,
-0.007043146528303623,
0.017072487622499466,
-0.0012152912095189095,
-0.0035155892837792635,
-0.005156482569873333,
-0.003045213408768177,
0.017341379076242447,
0.022403568029403687,
0.00027005880838260055,
-0.00018364627612754703,
-0.012991394847631454,
-0.004561456851661205,
-0.021447552368044853,
-0.021105676889419556,
0.003491097828373313,
0.006212830543518066,
-0.005702235735952854,
0.0008273809216916561,
0.01919342763721943,
-0.004170660860836506,
0.01057446375489235,
-0.014048163779079914,
0.025127585977315903,
-0.029897287487983704,
0.010126825422048569,
-0.012805936858057976,
-0.003780555445700884,
-0.01951981522142887,
-0.008883815258741379,
-0.00597082544118166,
-0.002031820360571146,
0.01446328591555357,
-0.009258391335606575,
0.022651828825473785,
-0.034227438271045685,
-0.02622809074819088,
0.03629340976476669,
0.008690984919667244,
-0.015036599710583687,
0.011208420619368553,
-0.008790072053670883,
-0.00983380526304245,
0.0017559193074703217,
0.004676720593124628,
-0.005865615792572498,
0.019925016909837723,
0.014635024592280388,
0.010869242250919342,
-0.007688645739108324,
-0.007567544002085924,
-0.017247484996914864,
0.006759651005268097,
-0.004483802244067192,
0.0663495883345604,
0.016041327267885208,
-0.014013923704624176,
-0.013823362998664379,
-0.00009335670620203018,
-0.0010689571499824524,
-0.021528717130422592,
0.0068976497277617455,
-0.010473884642124176,
0.006199173163622618,
-0.024187490344047546,
-0.002594640478491783,
0.022768592461943626,
0.02238280698657036,
0.0015420860145241022,
-0.00020586978644132614,
0.001474263146519661,
-0.006735166534781456,
-0.0018129810923710465,
0.022266997024416924,
0.040218256413936615,
0.015596674755215645,
-0.014572901651263237,
0.011473136022686958,
-0.017980800941586494,
-0.029167208820581436,
0.018849069252610207,
-0.00509040430188179,
-0.025616098195314407,
0.010163653641939163,
0.0006908930372446775,
0.008338777348399162,
0.017618760466575623,
-0.006912651006132364,
0.0036666132509708405,
-0.014894841238856316,
-0.002430792897939682,
-0.02347661554813385,
0.023022502660751343,
0.009746392257511616,
-0.010093197226524353,
0.002412684727460146,
0.010605229064822197,
-0.01827668584883213,
-0.019803769886493683,
0.008547711186110973,
0.0017019347287714481,
-0.013094786554574966,
0.007348490878939629,
-0.008332365192472935,
-0.007742713671177626,
0.0057493289932608604,
-0.014387481845915318,
-0.008243929594755173,
-0.021480852738022804,
-0.014436881989240646,
-0.02282196469604969,
0.01020011305809021,
-0.006129082292318344,
0.020444702357053757,
-0.011405080556869507,
-0.020450087264180183,
-0.04305408149957657,
0.02546054497361183,
-0.026688484475016594,
0.02033461444079876,
0.005851866211742163,
0.002466310979798436,
0.009148504585027695,
-0.0062245940789580345,
-0.016279349103569984,
0.003064444288611412,
-0.005461281631141901,
0.002123971236869693,
0.0016619786620140076,
-0.005905761383473873,
0.0023598382249474525,
-0.0010982714593410492,
-0.0024557658471167088,
0.022964799776673317,
-0.011989623308181763,
0.004122314974665642,
0.007380474358797073,
-0.009182275272905827,
0.004557588137686253,
-0.017923692241311073,
0.010443310253322124,
0.0006517535075545311,
0.02179652452468872,
0.015861082822084427,
0.005741882137954235,
0.007618407718837261,
-0.00337364268489182,
-0.005535483360290527,
-0.08164931833744049,
-0.014020737260580063,
-0.0062216646037995815,
0.010235140100121498,
0.007507779635488987,
0.001452078577131033,
0.007031370885670185,
0.010950714349746704,
-0.014394557103514671,
-0.024087034165859222,
0.0005334886955097318,
0.0016357977874577045,
-0.0020621391013264656,
0.03526140749454498,
0.0006115059368312359,
-0.0025214864872395992,
0.008686845190823078,
-0.009946443140506744,
-0.021304359659552574,
-0.021198490634560585,
0.020055383443832397,
0.00390089163556695,
0.03145931661128998,
-0.006967583205550909,
-0.010232146829366684,
0.007617131806910038,
0.013716506771743298,
0.003366266842931509,
-0.014165411703288555,
0.0020268200896680355,
0.014490088447928429,
-0.01143699511885643,
0.0040420000441372395,
-0.007403369527310133,
-0.022207843139767647,
-0.00021352432668209076,
-0.010028540156781673,
-0.016214657574892044,
-0.018216930329799652,
0.01980103924870491,
-0.010064952075481415,
0.0001831469126045704,
0.0019739398267120123,
-0.012684066779911518,
0.01422074157744646,
-0.01175243966281414,
0.007005423307418823,
0.0239248163998127,
0.019867127761244774,
0.02258869633078575,
0.021687641739845276,
-0.0036084488965570927,
0.01814846508204937,
0.01566007360816002,
-0.01799796149134636,
-0.01742836833000183,
-0.010387644171714783,
-0.017298182472586632,
-0.012709064409136772,
-0.013270314782857895,
-0.013569456525146961,
-0.02148568630218506,
0.016040876507759094,
0.017737977206707,
-0.0169827938079834,
-0.006130424793809652,
0.0014867964200675488,
-0.0014728365931659937,
0.0006522880867123604,
0.007314047776162624,
0.021514425054192543,
-0.020042888820171356,
-0.0018739216029644012,
-0.005876743234694004,
0.010574612766504288,
-0.015742262825369835,
-0.014331763610243797,
-0.0035897837951779366,
0.0558125376701355,
0.018432199954986572,
-0.010713877156376839,
0.014032093808054924,
-0.009000852704048157,
0.003112220438197255,
-0.0161916334182024,
0.009188439697027206,
0.0031213327310979366,
0.015264268964529037,
0.011893115937709808,
-0.006123361177742481,
0.013210639357566833,
0.015929363667964935,
-0.010196667164564133,
0.010079344734549522,
0.027386290952563286,
-0.010380597785115242,
0.007435816340148449,
0.005005612503737211,
0.01453457772731781,
0.006511380895972252,
-0.02611476555466652,
0.003372423816472292,
-0.0202634334564209,
-0.007522967178374529,
-0.017003657296299934,
0.00946533028036356,
0.006002591457217932,
0.027541421353816986,
-0.013597268611192703,
-0.010657748207449913,
-0.013007181696593761,
-0.019975874572992325,
-0.009494276717305183,
-0.011245176196098328,
0.007788367569446564,
-0.012258557602763176,
0.009394009597599506,
-0.01017950102686882,
0.07277820259332657,
-0.00992226880043745,
0.016528593376278877,
-0.015928391367197037,
-0.00154580338858068,
-0.006672686897218227,
-0.00414301548153162,
0.008261216804385185,
0.019887056201696396,
-0.0010002674534916878,
0.010226693004369736,
-0.023859845474362373,
-0.0019926591776311398,
-0.01529841497540474,
-0.011906015686690807,
0.006997520104050636,
0.011691516265273094,
-0.02995232120156288,
0.020892316475510597,
-0.014950141310691833,
0.01262596808373928,
-0.012757016345858574,
-0.010091446340084076,
-0.01082051545381546,
0.02156934142112732,
-0.03319618105888367,
-0.021011561155319214,
-0.009185689501464367,
-0.016392715275287628,
0.008044986985623837,
0.01595769077539444,
-0.022037889808416367,
-0.0054263221099972725,
-0.008130807429552078,
0.009690376929938793,
-0.008309988304972649,
0.01141105592250824,
-0.0021632015705108643,
0.00001845892984420061,
-0.00992848165333271,
-0.02879698947072029,
-0.013880370184779167,
0.014206184074282646,
-0.0015594289870932698,
0.00847984291613102,
-0.001972596626728773,
0.020293446257710457,
-0.005736234597861767,
0.0019751396030187607,
0.011357150971889496,
-0.00005178852006793022,
0.006265783216804266,
0.008709131740033627,
-0.005424111150205135,
-0.021038666367530823,
-0.013396784663200378,
-0.003550903871655464,
-0.007093704771250486,
-0.03264994919300079,
-0.016687292605638504,
0.005753159988671541,
-0.010880270972847939,
-0.002651403658092022,
-0.014492059126496315,
-0.008714590221643448,
-0.008890785276889801,
-0.0003395210951566696,
-0.006021326873451471,
-0.004826826974749565,
0.003836448770016432,
-0.0069788736291229725,
-0.023695271462202072,
-0.009015072137117386,
0.003938798792660236,
-0.023066148161888123,
-0.006482196971774101,
-0.005240297876298428,
0.02509646862745285,
0.016402125358581543,
-0.01100272685289383,
-0.01094741839915514,
-0.014446943998336792,
0.03780602663755417,
-0.024695109575986862,
0.014652613550424576,
0.03532753139734268,
0.006491733714938164,
-0.07531523704528809,
0.002128513064235449,
-0.00047165900468826294,
-0.010839356109499931,
-0.00554684130474925,
0.0067008002661168575,
-0.02962268516421318,
-0.009228784590959549,
-0.024799220263957977,
0.0059783607721328735,
0.017173876985907555,
-0.015490264631807804,
0.003128467593342066,
-0.007200831081718206,
0.00997154600918293,
0.014074447564780712,
0.009585989639163017,
0.0006049070507287979,
0.001597341150045395,
0.0016487869434058666,
0.02831966057419777,
0.004280378110706806,
-0.014812114648520947,
-0.009588352404534817,
-0.0030233210418373346,
-0.081666000187397,
-0.0032473006285727024,
0.0061533404514193535,
-0.013128582388162613,
0.01086411438882351,
-0.039851028472185135,
0.01059110276401043,
0.000640748767182231,
0.02012982964515686,
-0.012676868587732315,
-0.007792977150529623,
0.007455602288246155,
-0.0006751769687980413,
-0.004999140277504921,
0.00422062398865819,
-0.002820252673700452,
0.0034940331242978573,
0.010594275780022144,
0.0032171558123081923,
-0.008545590564608574,
0.016633838415145874,
0.0064909569919109344,
-0.006052376702427864,
0.010753100737929344,
-0.0115253496915102,
-0.004065448418259621,
-0.010613098740577698,
0.011161133646965027,
0.018507754430174828,
-0.01642492413520813,
0.019754063338041306,
-0.009325915947556496,
-0.015580279752612114,
-0.007490449585020542,
-0.014026106335222721,
-0.009811670519411564,
0.009458912536501884,
-0.002091726753860712,
0.00862954743206501,
-0.008220996707677841,
-0.005104436073452234,
-0.005796920042484999,
-0.021052377298474312,
0.005767517723143101,
-0.009655892848968506,
-0.017367497086524963,
0.00401342986151576,
-0.011800318025052547,
-0.0005806300323456526,
-0.013235294260084629,
0.008125261403620243,
-0.008093593642115593,
-0.009010108187794685,
-0.009735996834933758,
-0.013461210764944553,
-0.016290295869112015,
-0.008498921059072018,
0.026078101247549057,
-0.0374702587723732,
0.0032493053004145622,
-0.0066362409852445126,
0.026763450354337692,
0.0011102352291345596,
0.07140247523784637,
-0.003718019463121891,
0.004563913680613041,
-0.005921771749854088,
-0.017624078318476677,
0.0019214916974306107,
-0.023237815126776695,
0.0018511773087084293,
0.016921628266572952,
-0.009046841412782669,
-0.0015361650148406625,
-0.0036175656132400036,
0.010414768010377884,
0.009618977084755898,
-0.0027049900963902473,
-0.02437637373805046,
0.016744494438171387,
-0.022539062425494194,
0.0030168043449521065,
0.02713216096162796,
0.0038437717594206333,
0.02093113586306572,
-0.04316268861293793,
0.0065096477046608925,
0.014795391820371151,
-0.00905410572886467,
-0.026706229895353317,
-0.025604110211133957,
-0.00949629582464695,
0.013162926770746708,
0.0024118346627801657,
-0.008859412744641304,
0.004604038316756487,
0.03061138466000557,
0.009016042575240135,
-0.0019489922560751438,
0.014124255627393723,
0.0024987952783703804,
-0.0032678483985364437,
-0.007592680864036083,
0.008881174959242344,
0.009624236263334751,
-0.005317305214703083,
-0.018792051821947098,
0.027260925620794296,
-0.02498311549425125,
-0.005756373517215252,
-0.005672368220984936,
0.011443977244198322,
-0.0012093903496861458,
0.026803523302078247,
-0.0008945479057729244,
-0.015340527519583702,
0.0050840601325035095,
-0.011231129989027977,
0.023707235231995583,
-0.020922638475894928,
0.010810861364006996,
-0.02465609461069107,
-0.0034781182184815407,
-0.001192017225548625,
-0.01452342513948679,
0.0035516642965376377,
-0.021651361137628555,
0.001021048054099083,
-0.006921202875673771,
0.007752534002065659,
-0.01245539728552103,
-0.028651148080825806,
0.011276602745056152,
0.013772045262157917,
0.017270052805542946,
0.007117008790373802,
0.007686377037316561,
0.03930627182126045,
-0.00289513380266726,
-0.03049292601644993,
0.0015854077646508813,
0.00705476151779294,
0.002631383016705513,
-0.005657012574374676,
-0.017015963792800903,
-0.02200940251350403,
-0.0011197603307664394,
0.005917486734688282,
0.003925939556211233,
0.0030184516217559576,
0.019894246011972427,
-0.0010801564203575253,
0.00007219647523015738,
-0.01625915803015232,
-0.003134063445031643,
0.000919981743209064,
0.010841438546776772,
0.0023198991548269987,
0.033317312598228455,
0.0015980727039277554,
0.009296494536101818,
0.007863709703087807,
-0.014469181187450886,
-0.011298743076622486,
-0.0017863449174910784,
-0.0006687452550977468,
0.02242100052535534,
-0.002542909700423479,
0.006649734452366829,
0.026944560930132866,
-0.01251248735934496,
0.01175420917570591,
0.018347645178437233,
0.0036899675615131855,
-0.014268234372138977,
0.00869603268802166,
0.02305835485458374,
0.003080081893131137,
0.013721977360546589,
-0.01847008615732193,
0.008660756051540375,
-0.011673705652356148,
-0.013350045308470726,
-0.016775157302618027,
-0.008663618005812168,
0.00016956962645053864,
0.008758459240198135,
0.006272167898714542,
0.023254171013832092,
-0.0178140290081501,
-0.00283887330442667,
0.01052158698439598,
0.018106723204255104,
0.015245254151523113,
-0.0033275482710450888,
-0.006155266426503658,
-0.007509252987802029,
0.023784959688782692,
-0.002587053459137678,
-0.025454223155975342,
0.010477016679942608,
-0.02215457707643509,
0.009637637995183468,
0.006915335077792406,
0.0012551159597933292,
-0.007624111138284206,
-0.0036753718741238117,
0.008318409323692322,
-0.004412530921399593,
0.011956753209233284,
0.0029491272289305925,
0.014421318657696247,
-0.0042978692799806595,
-0.005460961256176233,
-0.002116307383403182,
0.005670587997883558,
-0.004843276925384998,
0.003233657218515873,
0.021483667194843292,
0.00966668501496315,
0.0306779183447361,
-0.010847804136574268,
-0.019695628434419632,
0.014560998417437077,
0.009051300585269928,
0.035768263041973114,
0.02719380334019661,
0.005423704162240028,
0.00027607253286987543,
-0.006667064502835274,
-0.011190210469067097,
-0.0069499025121331215,
0.021072259172797203,
0.021454928442835808,
-0.0035459455102682114,
-0.00432581827044487,
0.007080273702740669,
-0.008571024052798748,
-0.0007732184021733701,
-0.016219886019825935,
0.01888081058859825,
0.01618441380560398,
0.021237928420305252,
0.020005526021122932,
-0.03291553258895874,
-0.01192842423915863,
-0.009597759693861008,
0.007117852568626404,
-0.00019882735796272755,
0.0018724079709500074,
-0.015306573361158371,
0.0065450058318674564,
-0.004383377730846405,
-0.010994630865752697,
-0.004052103031426668,
0.000969164539128542,
-0.0005758648039773107,
-0.00633425684645772,
-0.011142079718410969,
-0.0026260605081915855,
-0.01747911609709263,
0.006239400710910559,
0.0008302308851853013,
-0.00008512265048921108,
-0.02474275976419449
] | [
0.3436886966228485,
-0.0182118471711874,
0.047624506056308746,
0.17775797843933105,
-0.42889204621315,
0.3598538935184479,
0.06991230696439743,
-0.45982155203819275,
0.21553665399551392,
-0.33297958970069885,
0.39277184009552,
0.3602279722690582,
-0.2849773168563843,
-0.297031968832016,
-0.08096786588430405,
0.7229675054550171,
0.3135159909725189,
0.33684173226356506,
0.03854719549417496,
-0.2686273157596588,
-0.2743184268474579,
-0.28036463260650635,
0.1389366090297699,
-0.2816959023475647,
0.23547211289405823,
0.24100548028945923,
0.29885485768318176,
-0.06206496059894562,
-0.5029646158218384,
-0.2557287812232971,
-0.11211826652288437,
0.496341735124588,
-0.11805678904056549,
-0.3500315546989441,
-0.10629233717918396,
-0.09542961418628693,
0.31839874386787415,
-0.0798145979642868,
-0.05007568746805191,
-0.17735540866851807,
-0.262811541557312,
0.2763986885547638,
0.042635779827833176,
0.8244979977607727,
-0.689418375492096,
-0.7256852388381958,
-1.3719841241836548,
0.14482751488685608,
-0.3923722803592682,
0.3939708471298218,
0.03810686245560646,
0.323232501745224,
0.09222573786973953,
0.3125248849391937,
-0.2960606813430786,
0.5527603626251221,
0.13233846426010132,
-0.3257639706134796,
-0.12073434144258499,
-0.6994614005088806,
0.32456284761428833,
0.4261547327041626,
0.13561666011810303,
0.17283415794372559,
-0.05822132155299187,
-0.022539520636200905,
-0.1148098036646843,
-0.2123805284500122,
-0.45181038975715637,
0.09668457508087158,
0.06442826241254807,
-0.03967876359820366,
-0.8084509968757629,
0.29599225521087646,
-0.14834223687648773,
-0.2472575455904007,
-0.32828763127326965,
0.1655157059431076,
0.3582470715045929,
-0.19349025189876556,
0.38989654183387756,
0.17918181419372559,
0.5529516339302063,
-0.5434841513633728,
0.4215453267097473,
0.3310776948928833,
-0.0372314490377903,
0.3614442050457001,
-0.24112525582313538,
-0.2907257676124573,
-0.15460443496704102,
-0.37201958894729614,
0.2430599182844162,
0.6182286739349365,
0.24091126024723053,
-0.11199558526277542,
0.2214672863483429,
-0.19110502302646637,
0.10946590453386307,
-0.05917828530073166,
-0.018552273511886597,
-0.23542751371860504,
0.021816231310367584,
-0.045977070927619934,
-0.6442757248878479,
-0.31064069271087646,
-0.3575402796268463,
-0.9592700004577637,
-0.15885648131370544,
0.2614261209964752,
-0.6275309920310974,
0.6718238592147827,
0.019299963489174843,
-0.5064624547958374,
-0.1343916952610016,
0.17880365252494812,
0.1472635120153427,
0.04133795201778412,
-0.31562942266464233,
0.48524603247642517,
0.08749757707118988,
0.9776782989501953,
-0.08818788081407547,
0.045983728021383286,
0.24288707971572876,
0.005825535394251347,
0.5194193720817566,
0.35551321506500244,
0.2782110869884491,
0.24492664635181427,
0.27592596411705017,
0.06768754124641418,
-0.09588328748941422,
-0.05142247676849365,
-0.29400405287742615,
-0.81577068567276,
0.2087828516960144,
-0.24134397506713867,
0.019114745780825615,
-0.14437317848205566,
-0.48791027069091797,
-0.5197061896324158,
-0.23445159196853638,
-0.13839660584926605,
0.5063146352767944,
-0.2688097059726715,
0.2778525650501251,
0.13779284060001373,
-0.14050985872745514,
0.1342291235923767,
-0.02063312754034996,
-0.12101336568593979,
-0.2776905298233032,
-0.23209556937217712,
0.06568403542041779,
0.2519367039203644,
-0.30255118012428284,
-0.08020968735218048,
-0.21271663904190063,
0.2503342628479004,
0.8434388041496277,
0.33767396211624146,
-0.38548150658607483,
-0.8548920154571533,
0.6296462416648865,
-0.3209620416164398,
0.146902933716774,
-0.0009271794115193188,
0.056119654327631,
0.026162704452872276,
-0.19450385868549347,
-0.4704234302043915,
0.26645809412002563,
0.005609204526990652,
-0.06387298554182053,
-0.027318760752677917,
0.13067619502544403,
0.18455906212329865,
0.42239972949028015,
-0.157632976770401,
-0.5255554914474487,
-0.2896665632724762,
-0.02587856352329254,
-0.5546630620956421,
0.3509766757488251,
-0.06899157166481018,
0.28719741106033325,
-0.16885939240455627,
0.6103183031082153,
0.17917804419994354,
-0.0860777497291565,
-0.5468335151672363,
0.46042031049728394,
-0.8660291433334351,
1.1923991441726685,
-0.4199906885623932,
-0.7522322535514832,
1.1257574558258057,
-0.052313897758722305,
-0.12208211421966553,
-0.11745403707027435,
0.003408080665394664,
0.46532580256462097,
-0.3654143810272217,
-0.40504199266433716,
-0.04763926938176155,
0.267605721950531,
-0.4300617277622223,
-0.5921210050582886,
0.6097800731658936,
-0.02457421086728573,
-0.13851958513259888,
-0.4856778681278229,
-0.21638484299182892,
-0.12041297554969788,
0.299014151096344,
0.12452429533004761,
0.43303194642066956,
-0.2004728764295578,
0.2615111172199249,
1.1137444972991943,
-0.33850178122520447,
0.16422875225543976,
0.3475877642631531,
-0.3863869607448578,
0.6450948119163513,
0.7939814329147339,
-0.1325010061264038,
0.6344426274299622,
-0.5095655918121338,
0.009519249200820923,
-0.27543905377388,
0.5138862729072571,
-0.4483826756477356,
-0.15919280052185059,
0.32247841358184814,
0.05772906914353371,
-0.11705303192138672,
0.7294650673866272,
0.36161693930625916,
-0.04655347019433975,
0.5015419125556946,
-0.4661526679992676,
0.28134992718696594,
-0.18586483597755432,
0.03541313111782074,
-0.19331695139408112,
0.7823770642280579,
-0.6566103100776672,
0.12087432295084,
0.02162277139723301,
-0.0070868730545043945,
0.10641106963157654,
-0.3041110634803772,
-0.12373176962137222,
0.45426079630851746,
-0.2608165144920349,
-0.5018634796142578,
0.892073392868042,
0.18088355660438538,
-0.2912764549255371,
0.10179457068443298,
0.5223531723022461,
-0.0765729695558548,
0.45690858364105225,
-0.20739439129829407,
-0.37137091159820557,
-0.7750905156135559,
0.5575242638587952,
0.5647822022438049,
0.8129934668540955,
0.24195851385593414,
-0.3976173400878906,
0.10836233198642731,
0.16508366167545319,
-0.5073034763336182,
0.1935998648405075,
0.45497503876686096,
-0.8896096348762512,
-0.5606375336647034,
0.06673723459243774,
0.29430899024009705,
0.8930957317352295,
0.41806069016456604,
-0.039268769323825836,
-0.1578347533941269,
0.15754415094852448,
-0.14862139523029327,
-0.41256871819496155,
-0.35038650035858154,
0.14238262176513672,
0.580442488193512,
-0.5219396948814392,
-0.6930638551712036,
0.5712369680404663,
0.4320584833621979,
-0.1460922211408615,
0.23133519291877747,
0.49640917778015137,
-0.20997045934200287,
0.3744785487651825,
0.13189099729061127,
0.26432928442955017,
0.11450865864753723,
0.4022562503814697,
-0.20753143727779388,
-0.25210702419281006,
0.2549011707305908,
-6.025928020477295,
-0.22635552287101746,
-0.46420520544052124,
0.38343992829322815,
-0.3602817952632904,
0.08526741713285446,
0.38906097412109375,
-0.011160343885421753,
0.19749702513217926,
-0.032999612390995026,
0.11012424528598785,
0.21767829358577728,
-0.014390249736607075,
0.261116623878479,
0.07345162332057953,
0.6147317290306091,
0.6414877772331238,
-0.26981866359710693,
0.20912718772888184,
0.6426817178726196,
-0.14710816740989685,
-0.3749742805957794,
-0.0838567465543747,
0.644244909286499,
0.635857343673706,
0.35631856322288513,
-1.24961256980896,
0.519620954990387,
0.3282427489757538,
-0.2879379689693451,
-0.14551065862178802,
-0.441697359085083,
-0.4012167155742645,
-0.3945750892162323,
0.42038410902023315,
0.38912221789360046,
0.29400137066841125,
0.001684680231846869,
0.5200486779212952,
-0.27186545729637146,
0.4300757050514221,
0.42575541138648987,
-0.13320933282375336,
-0.1372237205505371,
0.3548071086406708,
-0.2999558746814728,
-0.2111676186323166,
0.40316125750541687,
-0.30909523367881775,
0.2117190957069397,
0.021617881953716278,
0.21440209448337555,
0.2505374550819397,
0.4860999584197998,
0.014497300609946251,
0.10593105107545853,
-0.22592522203922272,
0.4556853771209717,
-0.48974287509918213,
0.2767092287540436,
0.24516400694847107,
-0.03550093248486519,
0.04248873516917229,
-0.3106800615787506,
-0.36470749974250793,
0.0326678641140461,
0.0802343487739563,
-0.07205124199390411,
0.036612506955862045,
0.0806027352809906,
-0.3976511061191559,
0.37413567304611206,
0.11909624934196472,
-0.6537963151931763,
0.6511526107788086,
-0.3765047490596771,
0.38561108708381653,
0.14696413278579712,
0.04991190508008003,
-0.19652551412582397,
-0.447971910238266,
-0.5042307376861572,
0.25589844584465027,
0.35193076729774475,
-0.080549456179142,
-0.07388857752084732,
0.08427630364894867,
0.3570582866668701,
-0.7271437644958496,
0.1749989092350006,
0.41566792130470276,
-0.16521382331848145,
0.03291263058781624,
0.6009742021560669,
0.23910899460315704,
0.05666903406381607,
0.8206413984298706,
-0.21441254019737244,
0.31043991446495056,
0.3389280438423157,
0.7281464338302612,
0.18333934247493744,
-0.42972496151924133,
-1.1707309484481812,
-0.35200437903404236,
-0.05835270509123802,
-0.7151501774787903,
0.06567444652318954,
0.6753409504890442,
-0.7271851301193237,
-0.33811071515083313,
0.35675129294395447,
-0.02322639711201191,
-0.08457422256469727,
0.5898424386978149,
0.42070725560188293,
-0.2365601807832718,
-0.5481495261192322,
0.28540247678756714,
-0.13961054384708405,
0.09295720607042313,
-0.10466036945581436,
-0.27904099225997925,
-0.049243438988924026,
-0.26170679926872253,
-0.6000474095344543,
0.33585065603256226,
0.6205337047576904,
-0.7225170731544495,
-0.025006253272294998,
0.32488176226615906,
0.5244914889335632,
-0.5033584833145142,
0.1475624293088913,
0.1465592384338379,
-0.48999157547950745,
-0.15017111599445343,
0.2933550477027893,
0.26455190777778625,
-0.1302044838666916,
0.42974406480789185,
-0.19999350607395172,
-0.294626384973526,
-0.10138669610023499,
-0.3325955867767334,
0.053103648126125336,
-0.11428815126419067,
-0.19085994362831116,
-0.21570666134357452,
0.09409042447805405,
0.20829404890537262,
-0.11030593514442444,
0.7441318035125732,
-0.057432904839515686,
0.01163562573492527,
-0.3454839289188385,
0.08665761351585388,
0.009533311240375042,
-0.046954263001680374,
-0.5907813906669617,
0.5949448943138123,
0.07333196699619293,
-1.1129556894302368,
-0.25193139910697937,
0.2013280987739563,
-0.2525085508823395,
0.08670037239789963,
-0.06191157549619675,
0.10697981715202332,
0.20938046276569366,
0.2095305174589157,
-0.4068658649921417,
0.31359776854515076,
-0.2183876931667328,
0.03163953870534897,
-0.24000228941440582,
-0.20404298603534698,
-0.46057358384132385,
-0.18998956680297852,
-0.0688915029168129,
0.5528532266616821,
-0.5862312316894531,
0.0030405314173549414,
0.3935339152812958,
0.717240035533905,
0.030225535854697227,
0.19354625046253204,
0.09192445874214172,
-0.042548298835754395,
-0.22713381052017212,
-0.3666081130504608,
0.01864326000213623,
0.77951979637146,
0.183406800031662,
-0.14528071880340576,
-0.07721821963787079,
0.4456427991390228,
0.3188343346118927,
-0.3036302328109741,
-0.010383108630776405,
-0.07818978279829025,
0.16787214577198029,
-0.3219588100910187,
0.38010305166244507,
0.31397518515586853,
-0.244532972574234,
-0.37443310022354126,
0.015829380601644516,
-0.01706826128065586,
-0.2736799716949463,
-0.4021955728530884,
-0.3308252692222595,
-0.23687054216861725,
-0.44655320048332214,
-0.3826981782913208,
0.3075234591960907,
-0.3002689778804779,
-0.2098010927438736,
-0.3285377323627472,
0.17221514880657196,
0.3064224421977997,
-0.5570729374885559,
-0.6113849878311157,
0.21451643109321594,
0.3546229302883148,
0.3294064998626709,
1.1224807500839233,
-0.33607861399650574,
-0.08187194168567657,
0.02515229396522045,
-0.5548474192619324,
0.17266255617141724,
0.06307392567396164,
0.23907731473445892,
-0.3324151337146759,
-0.1226484626531601,
-0.4788886606693268,
0.25192245841026306,
-0.3722169101238251,
-0.3907458782196045,
0.01161551009863615,
0.5370675921440125,
-0.5123878717422485,
-0.36662688851356506,
0.24063275754451752,
0.220285564661026,
-0.12711529433727264,
-0.4807998239994049,
-0.45798829197883606,
-0.17531818151474,
0.3334796726703644,
-0.7401742339134216,
0.24899384379386902,
-0.20803147554397583,
0.3283098638057709,
-0.4631591737270355,
-0.06143154948949814,
-0.12631863355636597,
-0.11439085751771927,
0.5025596022605896,
0.07045507431030273,
-0.17035560309886932,
-0.612464427947998,
0.019892781972885132,
-0.14028063416481018,
0.13153885304927826,
0.20132315158843994,
-0.5456749200820923,
0.3307226896286011,
-0.33156365156173706,
-0.042731769382953644,
0.08359619230031967,
-0.0690535455942154,
0.5249826908111572,
0.19807232916355133,
-0.5315125584602356,
-0.5547489523887634,
-0.03422379866242409,
-0.23013217747211456,
-0.4173027276992798,
-0.33312588930130005,
-0.12389206141233444,
0.5654716491699219,
-0.19452393054962158,
0.42529377341270447,
-0.5187546610832214,
-0.03144620731472969,
0.12740734219551086,
-0.4915918707847595,
-0.2269187718629837,
-0.24232593178749084,
0.10119552165269852,
-0.4723089635372162,
-1.0604872703552246,
-0.3028751015663147,
0.36870497465133667,
-0.15672534704208374,
0.13501571118831635,
0.028657229617238045,
-0.309414267539978,
0.22790968418121338,
0.2948848605155945,
0.7805117964744568,
-0.03854094445705414,
-0.4566434323787689,
0.21913598477840424,
0.1402001976966858,
-0.2410908192396164,
0.04786195978522301,
-0.016867568716406822,
0.42104288935661316,
-0.3582246005535126,
0.3796708285808563,
0.2611033618450165,
-0.6664833426475525,
0.11230338364839554,
-0.5493441224098206,
-0.5629591941833496,
0.4735305607318878,
0.364806205034256,
-0.17951546609401703,
0.42168962955474854,
0.5783429145812988,
0.1622922569513321,
-0.723827600479126,
0.139858216047287,
-0.2575083374977112,
0.6383282542228699,
-0.11159618198871613,
0.15030935406684875,
0.46248629689216614,
0.5485040545463562,
-0.32395124435424805,
0.033118776977062225,
0.05754772573709488,
0.17713375389575958,
0.6020808219909668,
-0.48596277832984924,
0.20518623292446136,
-0.11484664678573608,
0.6464794874191284,
0.4806416630744934,
-0.42020392417907715,
-0.3757890462875366,
-0.40983906388282776,
0.35996830463409424,
-0.18720471858978271,
0.14990782737731934,
-0.27405300736427307,
0.5384634137153625,
0.08919917047023773,
-0.12753649055957794,
-0.3764278292655945,
-0.18142975866794586,
-0.37218180298805237,
0.018377430737018585,
0.21318501234054565,
-0.4209458827972412,
-0.2949766218662262,
0.2771123945713043,
0.12138576060533524,
0.6675688624382019,
-0.05910274013876915,
-0.15436066687107086,
-0.6744847893714905,
-0.16352489590644836,
0.6732189655303955,
-0.17091666162014008,
0.33579397201538086,
0.2163010984659195,
-0.28676071763038635,
0.038107484579086304,
-0.25683340430259705,
-0.05206117033958435,
0.011784837581217289,
0.0555480532348156,
0.13538405299186707,
-0.02576112002134323,
0.027075637131929398,
0.6463786363601685,
0.1251721978187561,
-0.13210658729076385,
-0.5991300344467163,
-0.3881836533546448,
-0.3119748830795288,
-0.32626205682754517,
-0.20213556289672852,
0.35751327872276306,
-0.09236487746238708,
-0.14271080493927002,
-0.16969087719917297,
-0.2803398668766022,
0.3584432899951935,
0.2240612953901291,
-0.07097287476062775,
-0.1311327964067459,
-0.4496355354785919,
0.7924726009368896,
0.08853276073932648,
0.018430937081575394,
-0.5146468281745911,
-0.07705393433570862,
0.3015919625759125,
0.3774123787879944,
0.04316874220967293,
0.33998653292655945,
-0.8042948842048645,
-0.44156011939048767,
-0.5403221845626831,
0.03821635618805885,
0.5681714415550232,
0.04005277156829834,
-0.4796624481678009,
0.22923703491687775,
0.3596595525741577,
0.2533038258552551,
0.2916165292263031,
-0.16989777982234955,
-0.1550019532442093,
0.172155499458313,
-0.22592966258525848,
0.0031544133089482784,
0.2696014642715454,
0.3043029308319092,
-0.4694197177886963,
0.1833781749010086,
-0.11211451888084412,
0.29714566469192505,
-0.0510646253824234,
0.13510632514953613,
-0.5794950127601624,
-0.3203636109828949,
-0.6269277334213257,
0.3990321457386017,
-0.6078800559043884,
0.12800243496894836,
0.3779517114162445,
0.20858950912952423,
0.3127807378768921,
-0.14249925315380096,
-0.4225556254386902,
0.18414421379566193,
0.04708663001656532,
0.012459655292332172,
0.27209270000457764,
0.8860651254653931,
0.09726444631814957,
-0.5416545271873474,
-0.4049876630306244,
0.4485214650630951,
-0.03760761022567749,
0.20321914553642273,
0.18338797986507416,
0.003288569860160351,
-0.310001403093338,
0.14878924190998077,
0.0819244235754013,
-0.5921199917793274,
0.14612850546836853,
-0.046278826892375946
] |
Abstract Background: For the past 20 years numerous epidemiological studies have correlated the consumption of alcohol and a variety of disease states: overall mortality, arteriosclerotic vascular diseases, hypertension, cancers, peptic ulcer, respiratory infections, gall stones, kidney stones, age-related macular degeneration, bone density, and cognitive function. Methods: A review of these articles reveals that each of these studies has compared the outcome of individuals at various levels of alcohol consumption with that of abstainers. Results: Each analysis has identified a U-shaped or J-shaped curve of reduced relative risk for a given disease state compared with abstainers. A clear definition of consumption in moderation becomes evident: for men it should not exceed 2 to 4 drinks per day, and for women it should not exceed 1 to 2 drinks per day. Conclusions: Alcohol by itself has favorable effects on the level of high-density lipoprotein cholesterol, and inhibition of platelet aggregation. Wine, particularly red wine, has high levels of phenolic compounds that favorably influence multiple biochemical systems, such as increased high-density lipoprotein cholesterol, antioxidant activity, decreased platelet aggregation and endothelial adhesion, suppression of cancer cell growth, and promotion of nitric oxide production. | [
-0.0042091673240065575,
0.012597143650054932,
-0.010849421843886375,
0.018719179555773735,
0.007917262613773346,
-0.022684775292873383,
0.007916560396552086,
-0.009736740961670876,
-0.0070067280903458595,
-0.011867114342749119,
0.0047277286648750305,
0.004047120455652475,
-0.008794921450316906,
0.012969844043254852,
-0.004277361091226339,
0.016192082315683365,
-0.015268802642822266,
0.01403325516730547,
-0.00004897813778370619,
0.004289722535759211,
0.01946433074772358,
0.0017991247586905956,
0.009292172268033028,
0.023506682366132736,
0.004920690320432186,
0.015974801033735275,
0.02340555191040039,
-0.0065867118537425995,
0.01776375062763691,
-0.002470515202730894,
-0.003212569048628211,
0.009451441466808319,
-0.015270067378878593,
0.025376413017511368,
0.004747316241264343,
-0.009374413639307022,
0.002445040037855506,
0.012920346111059189,
0.022991839796304703,
-0.0038709959480911493,
0.0013817762956023216,
-0.006978267803788185,
0.0022848278749734163,
0.011575715616345406,
-0.006235136184841394,
-0.004068808164447546,
-0.003293717047199607,
0.01071451511234045,
0.003939731512218714,
0.012075907550752163,
-0.013567040674388409,
0.003907605540007353,
-0.014086276292800903,
-0.02033079043030739,
-0.005792161449790001,
-0.01702345535159111,
0.017858099192380905,
0.020580297335982323,
-0.012878825888037682,
0.0027794218622148037,
-0.0014516019728034735,
-0.009100915864109993,
0.0010218566749244928,
-0.020448163151741028,
-0.013488253578543663,
-0.06742662191390991,
-0.02598850056529045,
0.003902242286130786,
0.006573840044438839,
-0.029565315693616867,
-0.012940548360347748,
0.009075166657567024,
0.01127283088862896,
-0.025562375783920288,
-0.02614973485469818,
0.03554706647992134,
0.026319723576307297,
-0.007221035193651915,
0.013751838356256485,
-0.008781103417277336,
0.00029042636742815375,
0.006311280652880669,
-0.020202305167913437,
0.020565051585435867,
0.016508933156728745,
-0.015641838312149048,
-0.008790775202214718,
-0.017306288704276085,
0.002004820853471756,
0.008666264824569225,
-0.0180191732943058,
-0.00994106661528349,
0.005087592639029026,
0.014133473858237267,
-0.012799086049199104,
-0.010325167328119278,
-0.0021133648697286844,
0.025985535234212875,
-0.0006438689306378365,
-0.03591268137097359,
-0.008189835585653782,
-0.002385032596066594,
0.018627148121595383,
0.005028620362281799,
-0.004771582316607237,
0.005171440541744232,
0.003476556856185198,
-0.020398244261741638,
0.008304291404783726,
0.003197740763425827,
0.013449795544147491,
0.006346201524138451,
0.005329805426299572,
0.013607215136289597,
0.012369891628623009,
0.0033549934159964323,
-0.0016786109190434217,
0.001994818914681673,
0.004116619937121868,
-0.0174784604460001,
0.02297646552324295,
-0.00493196863681078,
0.000966197345405817,
0.004561673849821091,
-0.000599833088926971,
0.022047776728868484,
0.011214813217520714,
-0.00465170294046402,
-0.004029768519103527,
-0.004004423040896654,
-0.00439750449731946,
-0.015305169858038425,
-0.007677570916712284,
0.0024897533003240824,
0.003840644843876362,
-0.005353311076760292,
0.00924127921462059,
-0.015453056432306767,
-0.017665667459368706,
-0.013865252956748009,
-0.011557366698980331,
0.00730025302618742,
-0.0015615512384101748,
0.007491652388125658,
-0.030136890709400177,
-0.0015854467637836933,
0.023681078106164932,
0.011464639566838741,
-0.00029426137916743755,
0.0038118637166917324,
0.0021195532754063606,
-0.010592471808195114,
-0.0004337702412158251,
-0.015580563805997372,
-0.011571253649890423,
0.009218466468155384,
-0.0014267293736338615,
-0.011142155155539513,
0.007297847419977188,
0.004770527593791485,
0.005563856102526188,
-0.0035061899106949568,
0.011190013960003853,
0.008444640785455704,
0.013929713517427444,
0.018282856792211533,
-0.017624210566282272,
-0.021775590255856514,
0.012376549653708935,
0.0025416442658752203,
-0.004524442367255688,
0.0007453665602952242,
-0.002877101767808199,
0.009119104593992233,
0.008938200771808624,
0.0027897325344383717,
0.019375380128622055,
0.006024472415447235,
0.009184811264276505,
0.0670473724603653,
-0.0045253317803144455,
0.012454762123525143,
-0.01875149831175804,
0.01787932962179184,
-0.0021164994686841965,
-0.008719781413674355,
0.008142763748764992,
-0.007355669979006052,
0.0016455906443297863,
-0.02254304103553295,
-0.007670300081372261,
0.02145472727715969,
0.0084267258644104,
-0.014500413089990616,
-0.011266715824604034,
0.0034255480859428644,
0.0017699659802019596,
-0.007330631837248802,
-0.016912374645471573,
-0.004289662465453148,
0.0071732173673808575,
0.006127197295427322,
0.02183007448911667,
-0.007872113026678562,
0.020946696400642395,
0.0010109231807291508,
0.021552016958594322,
-0.0210290364921093,
-0.006257053464651108,
0.022885631769895554,
0.013516223058104515,
-0.00718303769826889,
-0.001576121780090034,
0.002963932929560542,
0.004535171668976545,
-0.005071030464023352,
0.008509316481649876,
0.007347632199525833,
-0.009278681129217148,
-0.01352421473711729,
0.00855279341340065,
0.0050165182910859585,
-0.016798511147499084,
-0.007037490606307983,
-0.008815165609121323,
-0.032835595309734344,
-0.002047180663794279,
0.008104910142719746,
0.0064168209210038185,
-0.007122242357581854,
0.0005224811611697078,
-0.011627266183495522,
-0.004254496656358242,
0.004887110088020563,
0.011207060888409615,
0.01601588912308216,
0.008857816457748413,
0.019680645316839218,
0.01923411339521408,
-0.009474840946495533,
-0.0018120290478691459,
-0.01823960244655609,
0.002172933891415596,
0.002717172959819436,
0.006662457715719938,
-0.025391653180122375,
0.016406625509262085,
0.00038512470200657845,
0.0031952918507158756,
-0.007971389219164848,
0.00017935235518962145,
-0.009779144078493118,
0.005131897982209921,
-0.003847237676382065,
0.011043095029890537,
-0.023835567757487297,
0.006136536132544279,
-0.024120211601257324,
0.02590417116880417,
0.008958643302321434,
0.009980442002415657,
0.005593298468738794,
0.02895534411072731,
0.0028822999447584152,
0.009746167808771133,
-0.004461093805730343,
0.01604820042848587,
0.00274904677644372,
0.00815146416425705,
-0.0027103452011942863,
0.004351919516921043,
-0.009000999853014946,
-0.0016695610247552395,
-0.08231741189956665,
-0.0033397641964256763,
-0.006251121871173382,
0.0029160333797335625,
0.00775868259370327,
-0.01773579604923725,
-0.0021159444004297256,
0.00028638215735554695,
-0.018343361094594002,
-0.015614340081810951,
0.014979178085923195,
-0.012585140764713287,
0.0011423854157328606,
-0.002816322958096862,
0.016153937205672264,
0.0013797462452203035,
0.007066819351166487,
0.008110284805297852,
-0.009234100580215454,
-0.017574714496731758,
0.0017870251322165132,
0.010178904980421066,
0.014989079907536507,
-0.0047498224303126335,
-0.001376650994643569,
-0.00823475793004036,
-0.007569347973912954,
-0.009215340949594975,
-0.005367217119783163,
0.012844439595937729,
0.016405319795012474,
-0.023207450285553932,
0.00943433865904808,
0.010705732740461826,
-0.028615755960345268,
0.013273349031805992,
0.0038396299351006746,
-0.026139546185731888,
-0.004741008393466473,
0.01581372320652008,
0.011531940661370754,
0.004046754911541939,
-0.00839792750775814,
0.003535756142809987,
0.008955348283052444,
0.00031066499650478363,
0.014757484197616577,
0.007543252781033516,
0.006979652214795351,
-0.01934761181473732,
0.020327389240264893,
-0.0051106614992022514,
0.017014015465974808,
0.010476739145815372,
-0.005633337423205376,
-0.031559448689222336,
-0.011906690895557404,
-0.02735486999154091,
-0.011287542060017586,
-0.010069042444229126,
0.0036054826341569424,
-0.0001560710370540619,
0.008173855021595955,
0.023870963603258133,
0.03810519725084305,
-0.02551852911710739,
0.017756396904587746,
0.014693429693579674,
-0.015228391624987125,
0.013767040334641933,
0.02379930578172207,
-0.013101216405630112,
-0.0055068014189600945,
-0.010790427215397358,
0.008768859319388866,
-0.012620183639228344,
-0.013988157734274864,
0.004371858201920986,
-0.0014101138804107904,
0.004415364935994148,
0.006344071589410305,
-0.004512113519012928,
-0.013456362299621105,
-0.011811215430498123,
-0.01948171854019165,
-0.01407392043620348,
0.004916715435683727,
-0.0007688819896429777,
0.005397985689342022,
-0.014092488214373589,
0.020229456946253777,
-0.002171718515455723,
0.00452521163970232,
0.009312620386481285,
0.009567094966769218,
0.0038515329360961914,
-0.003972274716943502,
-0.014075890183448792,
-0.0026697791181504726,
0.00799538567662239,
0.002956201322376728,
0.013239096850156784,
-0.00315729808062315,
-0.0054120877757668495,
-0.020750325173139572,
0.014911863021552563,
0.0090570617467165,
0.014123557135462761,
-0.0011234530247747898,
-0.005866727326065302,
-0.011256406083703041,
-0.012053580954670906,
-0.007609369233250618,
0.029160454869270325,
0.012673621065914631,
-0.002034575678408146,
-0.0035242107696831226,
-0.010491220280528069,
0.07256047427654266,
0.009225867688655853,
0.01038306299597025,
-0.004355600569397211,
0.023701321333646774,
-0.009581566788256168,
-0.012767741456627846,
-0.00023178872652351856,
-0.003383265808224678,
0.01836380362510681,
0.012919092550873756,
-0.006994502153247595,
0.0075493305921554565,
-0.013864642940461636,
0.008051618933677673,
0.00845160149037838,
0.004407066386193037,
0.012016846798360348,
-0.015646863728761673,
-0.020383182913064957,
-0.016068261116743088,
0.0037611648440361023,
-0.012730976566672325,
-0.017562802881002426,
0.009559080004692078,
-0.01843814179301262,
-0.0019466531230136752,
-0.010326867923140526,
-0.0036579498555511236,
-0.0016512619331479073,
0.014629622921347618,
0.003964383155107498,
-0.0037559953052550554,
0.0052914097905159,
-0.007797450292855501,
0.01996239647269249,
0.019244199618697166,
-0.001350853592157364,
0.0018546218052506447,
-0.00964168831706047,
-0.00961493793874979,
-0.013168534263968468,
0.01816868968307972,
0.0072899204678833485,
-0.013329396955668926,
0.018689805641770363,
0.008696386590600014,
-0.0019166143611073494,
0.003211553441360593,
0.01093420572578907,
-0.0002462952397763729,
-0.004532781895250082,
0.006924577988684177,
-0.015252616256475449,
-0.0011162729933857918,
0.024019241333007812,
-0.006566348485648632,
0.007502267137169838,
-0.029336079955101013,
-0.0018355417996644974,
-0.0033674396108835936,
-0.03315607085824013,
0.0011243801563978195,
-0.01002182625234127,
-0.0007412112317979336,
-0.002922668820247054,
0.01102891843765974,
-0.020767908543348312,
-0.001181071624159813,
0.017775824293494225,
-0.002910374430939555,
0.012479633092880249,
0.00030940258875489235,
-0.010405807755887508,
-0.016593320295214653,
-0.023502713069319725,
-0.013278868980705738,
-0.016227390617132187,
0.001907458296045661,
-0.015146887861192226,
-0.008893154561519623,
-0.009321348741650581,
0.008842365816235542,
-0.009563764557242393,
0.01783818006515503,
0.0016012639971449971,
-0.023978035897016525,
-0.07517009973526001,
0.00033475132659077644,
0.007616491988301277,
-0.0074116745963692665,
-0.002999290358275175,
-0.004569590091705322,
-0.021057693287730217,
0.004411226604133844,
-0.010189943015575409,
-0.0009643848752602935,
0.007160825654864311,
0.00916658341884613,
-0.020197145640850067,
0.003505886998027563,
0.011200659908354282,
0.00600662175565958,
-0.006009735632687807,
0.005430454388260841,
0.027584794908761978,
0.021148189902305603,
-0.001035206252709031,
0.031922198832035065,
-0.046937692910432816,
-0.008624689653515816,
-0.0053754402324557304,
-0.08142116665840149,
-0.010316908359527588,
-0.0002013547345995903,
-0.032754380255937576,
0.0013462400529533625,
0.0038408597465604544,
-0.010971195064485073,
0.005825618747621775,
0.007608695421367884,
-0.016302376985549927,
-0.0011409713188186288,
0.0015299636870622635,
0.0034685067366808653,
0.00033924495801329613,
-0.019054515287280083,
-0.0021423448342829943,
0.0039025722071528435,
0.002668667584657669,
-0.014966011978685856,
-0.0016269499901682138,
0.0344126932322979,
0.0010968160349875689,
-0.003079062793403864,
0.0018723527900874615,
-0.005664485972374678,
-0.014747735112905502,
-0.020127538591623306,
-0.00383244501426816,
0.026205608621239662,
-0.003874338697642088,
-0.004221449606120586,
0.006157614756375551,
-0.01487887091934681,
0.0027410537004470825,
-0.006707211025059223,
-0.02051869034767151,
0.007952157407999039,
-0.007308010943233967,
0.0035905716940760612,
-0.0059890178963541985,
-0.00018116511637344956,
-0.006413103546947241,
0.002784570213407278,
0.015577487647533417,
-0.006601559929549694,
0.0029909261502325535,
0.004059704951941967,
-0.006289910990744829,
0.017560601234436035,
0.007245941087603569,
-0.0020871199667453766,
-0.012372754514217377,
0.02089777961373329,
-0.01008023414760828,
-0.004518464207649231,
0.008855219930410385,
-0.012478247284889221,
-0.0031788910273462534,
0.005077556241303682,
0.0013570886803790927,
-0.00019888515817001462,
-0.0080868573859334,
0.005423370748758316,
0.07193632423877716,
-0.010956350713968277,
0.00011198781430721283,
0.004548290278762579,
-0.018743425607681274,
-0.0004813749110326171,
-0.02988072857260704,
0.006385082378983498,
-0.0002540347632020712,
-0.016446303576231003,
-0.01614895462989807,
-0.011608979664742947,
-0.01336982473731041,
0.006365139503031969,
-0.006708743050694466,
-0.020809056237339973,
-0.01084082294255495,
-0.00031979731284081936,
-0.016416147351264954,
-0.004913124721497297,
-0.03167327493429184,
0.018692847341299057,
-0.026123691350221634,
-0.004841485992074013,
0.02860765904188156,
-0.01905493251979351,
-0.017549872398376465,
-0.0027227564714848995,
0.00505820894613862,
-0.0021827332675457,
-0.010605559684336185,
0.0047913808375597,
0.0036114854738116264,
0.00390963489189744,
0.011122576892375946,
-0.0009038741700351238,
-0.002090522088110447,
-0.002223169431090355,
-0.018999319523572922,
0.003465407295152545,
0.03488047420978546,
-0.010198873467743397,
0.006960920058190823,
-0.021784568205475807,
0.024096215143799782,
-0.006949113216251135,
0.008335545659065247,
-0.01853727549314499,
-0.013188043609261513,
0.02084825374186039,
-0.004296833649277687,
0.005081768147647381,
-0.0023775105364620686,
0.0023494516499340534,
-0.0033979557920247316,
0.005290620494633913,
-0.024846971035003662,
0.014673437923192978,
0.013301212340593338,
-0.03030737116932869,
-0.0004516888875514269,
-0.012862203642725945,
-0.012269848957657814,
-0.02432236075401306,
-0.004376713652163744,
-0.01311350055038929,
0.013511992990970612,
-0.004255375824868679,
-0.022183993831276894,
0.009297100827097893,
0.018048647791147232,
-0.001487797824665904,
0.005037399474531412,
-0.006087126210331917,
-0.0020446227863430977,
-0.007353417109698057,
0.005751453805714846,
-0.0176598709076643,
0.019171634688973427,
-0.0037447535432875156,
-0.0019706585444509983,
-0.004970008973032236,
0.012800500728189945,
-0.0027108676731586456,
-0.022005895152688026,
0.0073237344622612,
0.014555277302861214,
-0.00044324109330773354,
-0.009139984846115112,
-0.00003297475632280111,
0.008749574422836304,
0.0011306263040751219,
0.00483364425599575,
0.020765773952007294,
0.008321288041770458,
0.035257868468761444,
0.00597173860296607,
-0.0015291804447770119,
0.014011887833476067,
-0.005672211293131113,
0.01872575655579567,
0.009457741864025593,
-0.0017600040882825851,
0.018388694152235985,
0.001851503038778901,
-0.002845676615834236,
0.012960944324731827,
-0.005324479192495346,
0.0031288405880331993,
-0.005739598069339991,
0.0036774990148842335,
-0.0038460996001958847,
0.012972148135304451,
0.0025318381376564503,
-0.004158005118370056,
0.01572641171514988,
-0.006488707847893238,
-0.014428511261940002,
0.01176370494067669,
-0.017076890915632248,
-0.027836468070745468,
-0.012599686160683632,
0.007777116261422634,
0.013685580343008041,
-0.017002373933792114,
-0.002951798727735877,
-0.008807145059108734,
-0.017344065010547638,
0.012136959470808506,
-0.00013793306425213814,
0.009192713536322117,
0.015477664768695831,
-0.029021194204688072,
0.0071005914360284805,
0.00699331471696496,
-0.006722590886056423,
-0.0012669754214584827,
0.011568122543394566,
-0.008458392694592476,
-0.004217637702822685,
0.03217855840921402,
-0.010049961507320404,
-0.011365680024027824,
0.0015589455142617226,
0.007455109618604183,
-0.011775900609791279,
0.00862974114716053,
0.007429732475429773,
0.02459336817264557,
0.002088963519781828,
0.004124727100133896,
-0.012324594892561436,
0.0107958372682333,
-0.001083810580894351,
0.003749234601855278,
0.012211795896291733,
0.003996876068413258,
0.005511635914444923,
-0.0034924692008644342,
-0.027147267013788223,
-0.0001952963648363948,
-0.030862290412187576,
0.02287646010518074,
0.00018467195332050323,
0.003941953182220459,
-0.001522532431408763,
-0.0010473030852153897,
0.00022230774629861116,
-0.019367918372154236,
0.03078642673790455,
0.01109630148857832,
0.017811160534620285,
-0.0034594861790537834,
0.009183721616864204,
-0.02732882648706436,
-0.009070754051208496,
0.0017288119997829199,
0.003536622039973736,
-0.023099260404706,
0.01727643609046936,
0.014263885095715523,
0.0009067743085324764,
-0.0012987892841920257,
-0.007271006237715483,
-0.0017982283607125282,
-0.004674426279962063,
-0.004423066973686218,
0.016284050419926643,
0.000027742469683289528,
-0.0008958674734458327,
-0.008538298308849335,
-0.00031221192330121994,
-0.008775793015956879,
-0.007632348220795393,
-0.02463981695473194,
0.0051578739657998085,
0.001851770095527172,
-0.01369969081133604,
-0.0006694656331092119,
0.01338677667081356,
0.0037078368477523327,
-0.007832199335098267
] | [
0.3053259253501892,
0.5430647730827332,
0.09086713939905167,
0.04878281056880951,
-0.2665238380432129,
0.5047486424446106,
0.4229685366153717,
-0.0654938817024231,
-0.13856352865695953,
-0.3594636917114258,
0.41189032793045044,
0.37583452463150024,
-0.004172893241047859,
0.20938317477703094,
0.07479104399681091,
0.8948248624801636,
0.4496642053127289,
0.8238544464111328,
0.11357812583446503,
-0.39056625962257385,
-0.36630624532699585,
-0.12288752943277359,
0.5606080293655396,
-0.27941998839378357,
-0.04201260954141617,
-0.07525632530450821,
0.2242254912853241,
-0.027061866596341133,
-0.4114921987056732,
0.24729867279529572,
-0.20904161036014557,
0.952106773853302,
-0.1566552370786667,
-0.03764624148607254,
0.03112812526524067,
0.08797765523195267,
0.019117169082164764,
-0.05130091309547424,
0.37224477529525757,
-0.06396911293268204,
-0.40502506494522095,
0.0019480236805975437,
-0.19853848218917847,
0.7631174325942993,
-0.28627970814704895,
-0.564178466796875,
-1.341383695602417,
0.3309987187385559,
-0.29331210255622864,
-0.02442152239382267,
0.15377844870090485,
0.11947261542081833,
0.1125139519572258,
0.21585211157798767,
0.019457848742604256,
0.49505817890167236,
-0.04524825140833855,
0.161704882979393,
0.3661758303642273,
-0.2506987750530243,
0.5293554067611694,
0.28565236926078796,
-0.008443362079560757,
-0.09535328298807144,
-0.5257604718208313,
-0.09694959223270416,
-0.038857925683259964,
0.15677034854888916,
-0.6353139281272888,
-0.03146190941333771,
-0.02160835638642311,
-0.25419357419013977,
-0.5357928276062012,
0.0028318448457866907,
-0.10155898332595825,
0.10329365730285645,
0.007119733840227127,
-0.17436586320400238,
0.10103607922792435,
-0.3847503066062927,
0.25305962562561035,
-0.07635674625635147,
0.232143834233284,
-0.2412710189819336,
0.29524949193000793,
0.17767076194286346,
0.10355310142040253,
0.4121413230895996,
-0.35697314143180847,
-0.1330702006816864,
-0.22595112025737762,
0.14010852575302124,
0.6271294355392456,
0.43014127016067505,
-0.0783521831035614,
0.0339338593184948,
0.7005732655525208,
-0.06956887990236282,
0.5241267085075378,
0.32577747106552124,
0.07589177042245865,
-0.1569906771183014,
-0.2953040599822998,
0.12786218523979187,
-0.31779733300209045,
-0.12252582609653473,
-0.03641262277960777,
-0.3814470171928406,
-0.11040207743644714,
0.17307865619659424,
-0.767981767654419,
0.6718805432319641,
-0.13347166776657104,
0.18914785981178284,
-0.0326327309012413,
0.1474171131849289,
-0.17512066662311554,
-0.15487799048423767,
0.07930909097194672,
0.27421149611473083,
-0.3240666389465332,
0.4975408911705017,
-0.3759757876396179,
0.11133404076099396,
0.1739334911108017,
0.20154665410518646,
0.7010340690612793,
0.11756914854049683,
0.10075180977582932,
0.014342186041176319,
0.3605283498764038,
-0.0376487635076046,
-0.22496503591537476,
0.04274006932973862,
-0.33088400959968567,
-0.28892961144447327,
0.18467724323272705,
0.3051527440547943,
0.39980611205101013,
-0.3000197410583496,
-0.6645354628562927,
-1.0202292203903198,
-0.4974135458469391,
-0.3505169153213501,
0.19882071018218994,
-0.3049440085887909,
0.20534266531467438,
0.04430384188890457,
-0.2795000374317169,
-0.10440673679113388,
0.10541156679391861,
0.13979224860668182,
-0.4029858112335205,
-0.044567596167325974,
0.40274956822395325,
0.3209192454814911,
-0.48079541325569153,
-0.26487359404563904,
-0.306262731552124,
-0.1784926950931549,
0.5155240297317505,
0.1503232717514038,
-0.3688066303730011,
-0.4383430778980255,
0.5335834622383118,
-0.30811694264411926,
-0.2760191559791565,
0.5174480080604553,
-0.2685354948043823,
-0.09920653700828552,
-0.21799898147583008,
0.20051684975624084,
-0.05796369910240173,
-0.34585055708885193,
-0.15062104165554047,
0.5659152865409851,
0.052538469433784485,
0.3157815635204315,
0.16142071783542633,
0.4217267334461212,
-0.696559488773346,
0.06689698249101639,
-0.004856112413108349,
-0.5735690593719482,
-0.1868385225534439,
-0.161756232380867,
0.0948394164443016,
-0.27012374997138977,
0.31076106429100037,
-0.12287651002407074,
-0.15050701797008514,
-0.45246124267578125,
0.392275333404541,
-0.6913772225379944,
1.099679708480835,
-0.44288602471351624,
-0.7549570202827454,
0.8508277535438538,
0.20975907146930695,
-0.4248914122581482,
-0.06503604352474213,
0.08691135048866272,
0.20086807012557983,
-0.33339110016822815,
-1.0509464740753174,
0.22063487768173218,
0.18852943181991577,
-0.4205106198787689,
-0.4599981904029846,
0.13550937175750732,
0.4723733961582184,
-0.4022676348686218,
-0.30266866087913513,
-0.24422132968902588,
-0.19334524869918823,
0.2505514621734619,
-0.1704241782426834,
0.46326005458831787,
-0.3115951418876648,
0.26130616664886475,
0.41857415437698364,
-0.2725747525691986,
0.369500994682312,
0.5131046772003174,
0.19946759939193726,
0.37842825055122375,
0.8213279843330383,
0.3198135197162628,
0.6963467001914978,
-0.8770028948783875,
0.5320296287536621,
-0.04444465786218643,
0.40697550773620605,
-0.4015809893608093,
-0.3548564314842224,
0.1806587427854538,
0.025193149223923683,
0.040419623255729675,
-0.15939846634864807,
-0.024367820471525192,
0.08680282533168793,
0.2005407065153122,
-0.36230015754699707,
0.5378435850143433,
-0.23421798646450043,
-0.3298141062259674,
-0.5043298602104187,
0.31940487027168274,
-0.8594319820404053,
0.044924184679985046,
0.03053644858300686,
0.44011810421943665,
0.0979989543557167,
-0.19024838507175446,
0.13551048934459686,
0.01668640226125717,
-0.1794714629650116,
-0.40691477060317993,
0.1872176080942154,
-0.11382326483726501,
-0.17870305478572845,
0.3635205924510956,
0.4072735011577606,
-0.0029817656613886356,
0.29801541566848755,
-0.3773687779903412,
-0.7688860893249512,
-0.6797338128089905,
0.2237328439950943,
0.5050046443939209,
0.7965850830078125,
0.029215866699814796,
-0.8470486998558044,
0.3894293010234833,
-0.2875698506832123,
-0.4388878345489502,
0.245589479804039,
0.3804071545600891,
-0.929358184337616,
-0.22395238280296326,
-0.05155903473496437,
0.5249362587928772,
0.8988725543022156,
-0.06059207767248154,
-0.5292365550994873,
-0.5652928948402405,
0.1309138983488083,
-0.2023548036813736,
-0.2642396092414856,
-0.03442602604627609,
0.019186342135071754,
0.4315572679042816,
-0.027091965079307556,
-0.6384304761886597,
0.6888332366943359,
0.32544028759002686,
-0.2173117995262146,
0.25276103615760803,
0.5087445974349976,
-0.02768537774682045,
0.16159789264202118,
0.2106824517250061,
-0.3511172831058502,
0.03291356563568115,
0.13299429416656494,
-0.12208842486143112,
-0.5549883246421814,
0.4041040241718292,
-6.10675048828125,
-0.04481728747487068,
-0.5662029385566711,
-0.23537594079971313,
-0.19612663984298706,
-0.33166855573654175,
1.0323950052261353,
-0.49122896790504456,
0.0034431901294738054,
-0.014152691699564457,
0.6659607887268066,
0.445767343044281,
0.05693972855806351,
0.4077535569667816,
0.2607676386833191,
0.12146097421646118,
0.6169632077217102,
-0.7006570100784302,
0.04338590428233147,
0.08638370782136917,
-0.05854770913720131,
-0.049699462950229645,
-0.2706015408039093,
0.7267881631851196,
-0.15052063763141632,
0.19839681684970856,
-0.49726182222366333,
0.40577197074890137,
-0.26734891533851624,
-0.1990600973367691,
0.04741692543029785,
-0.06553313881158829,
-0.20550163090229034,
-0.346170037984848,
0.4932878017425537,
0.423257440328598,
0.06346052139997482,
0.056082673370838165,
0.2343818098306656,
0.0045858086086809635,
0.10036759078502655,
0.4570530652999878,
-0.0435282327234745,
-0.1437283605337143,
0.4378124475479126,
-0.06719408929347992,
-0.32574033737182617,
0.08688445389270782,
-0.4357755184173584,
0.4011833965778351,
-0.011509954929351807,
-0.18435142934322357,
0.11807738989591599,
0.5882614254951477,
0.13391052186489105,
0.12365346401929855,
0.15016257762908936,
0.2573137581348419,
-0.4348060190677643,
0.18934449553489685,
0.1304820328950882,
-0.09314444661140442,
0.28839653730392456,
-0.278344064950943,
-0.2603011429309845,
0.24488627910614014,
-0.4355744421482086,
-0.5841472148895264,
0.15623030066490173,
0.06520497798919678,
-0.5965315699577332,
0.16124318540096283,
0.3406836688518524,
-0.6045145392417908,
0.2139551341533661,
-0.2551261782646179,
0.2568718492984772,
0.2848256528377533,
-0.09718748182058334,
0.10544297844171524,
-0.24739231169223785,
0.11282794177532196,
0.16607001423835754,
-0.04344315454363823,
0.001597124501131475,
-0.21684427559375763,
-0.04845394939184189,
0.133257195353508,
-0.48119691014289856,
0.14315442740917206,
0.42675870656967163,
-0.22801119089126587,
0.48841312527656555,
0.36896175146102905,
0.04708828777074814,
0.8259832859039307,
0.2733444571495056,
0.15126672387123108,
0.11373071372509003,
-0.10800981521606445,
0.9160035848617554,
-0.2237255722284317,
-0.48502784967422485,
-0.9945183396339417,
-0.17139042913913727,
0.061521805822849274,
-0.02844538912177086,
-0.028681814670562744,
0.6501014232635498,
-1.0856738090515137,
0.10351364314556122,
0.5200097560882568,
-0.20877565443515778,
-0.33696338534355164,
0.5733202695846558,
-0.3063318133354187,
-0.20216722786426544,
0.17523084580898285,
0.5218830108642578,
-0.05960175767540932,
0.17600588500499725,
0.2283409833908081,
-0.02827686071395874,
-0.2912817597389221,
-0.14099881052970886,
-0.6508482694625854,
0.29097533226013184,
0.23606489598751068,
-0.4996287226676941,
0.31766095757484436,
0.5554996132850647,
0.6796875596046448,
-0.2693306505680084,
0.41193345189094543,
-0.08500663936138153,
-0.04491999000310898,
-0.04791492596268654,
0.39285802841186523,
0.055904924869537354,
-0.3673740327358246,
0.3975428640842438,
-0.25153276324272156,
-0.5461997389793396,
-0.21451298892498016,
0.08641546964645386,
0.15889878571033478,
-0.5432251691818237,
0.1938682645559311,
0.10253294557332993,
0.16543890535831451,
-0.1848999559879303,
0.2461131364107132,
0.16119030117988586,
0.03850872442126274,
-0.26477083563804626,
0.028561316430568695,
0.5130655169487,
0.4307519197463989,
-0.31982162594795227,
-0.4832204282283783,
0.536185622215271,
-0.5098996162414551,
-1.2065802812576294,
-0.2140776664018631,
-0.09460671991109848,
0.04209420830011368,
-0.1452692449092865,
0.008688037283718586,
-0.0007973352912813425,
0.563347339630127,
-0.32456013560295105,
-0.18014636635780334,
-0.35736146569252014,
-0.16407997906208038,
0.3560207188129425,
-0.03363404422998428,
-0.3172787129878998,
0.07667607814073563,
-0.24675282835960388,
-0.26061609387397766,
0.0582381896674633,
-0.4097508490085602,
-0.4799366295337677,
0.13966059684753418,
0.7002246975898743,
-0.1061284989118576,
-0.12400545924901962,
0.04178828001022339,
0.12338051199913025,
-0.18787109851837158,
-0.18794651329517365,
-0.09095141291618347,
0.42221230268478394,
-0.12162695825099945,
0.12359544634819031,
-0.3625224530696869,
0.23735035955905914,
0.3708958327770233,
-0.23868820071220398,
-0.09863287210464478,
0.34132346510887146,
0.4307580590248108,
-0.393894761800766,
0.2902306914329529,
0.44526395201683044,
-0.3796294331550598,
-0.35827651619911194,
-0.027792245149612427,
-0.5897839665412903,
-0.15239708125591278,
-0.3954116702079773,
-0.5659763813018799,
-0.5261939764022827,
0.15279626846313477,
-0.02917644754052162,
0.1607203632593155,
0.0590011365711689,
-0.10752678662538528,
-0.3998079001903534,
0.4611591398715973,
0.8436262011528015,
-0.16851842403411865,
-0.6658664345741272,
0.07293571531772614,
-0.21950946748256683,
0.028550174087285995,
0.4803776443004608,
-0.6298803091049194,
0.2855151295661926,
0.39253926277160645,
-0.4495962858200073,
0.2775283753871918,
-0.015846822410821915,
0.44155871868133545,
-0.06938177347183228,
-0.43250197172164917,
-0.381807416677475,
0.38885796070098877,
-0.25793689489364624,
0.18041129410266876,
-0.3044236898422241,
0.6709957718849182,
-0.12422128021717072,
-0.6833524107933044,
0.012536805123090744,
0.07907436788082123,
0.03497888147830963,
-0.4398800730705261,
-0.3724735975265503,
0.07445429265499115,
0.21587985754013062,
-0.6078585386276245,
0.4540669918060303,
0.06216425821185112,
0.28779491782188416,
0.2187757045030594,
0.0015781885012984276,
-0.24853408336639404,
0.4100070595741272,
0.3933294117450714,
-0.17842236161231995,
-0.27493709325790405,
-0.5009251236915588,
0.11306335777044296,
0.0874861404299736,
-0.1846974939107895,
-0.3227698802947998,
-0.4744992256164551,
0.3531928062438965,
-0.23606468737125397,
0.32163190841674805,
0.14026562869548798,
0.35519838333129883,
0.6062254905700684,
0.01682860217988491,
0.16597256064414978,
-0.26716071367263794,
-0.3412562310695648,
-0.12246622890233994,
0.044914547353982925,
-0.4812483489513397,
-0.4875680208206177,
0.2173449546098709,
-0.2625890374183655,
0.1295655220746994,
-0.23486429452896118,
-0.0028782656881958246,
-0.2418244481086731,
-0.3094981610774994,
-0.32129988074302673,
-0.09597831964492798,
0.3588562309741974,
-0.562437891960144,
-0.4458182454109192,
-0.06303906440734863,
0.09645234793424606,
0.2768501937389374,
0.23404894769191742,
-0.07575847208499908,
-0.4681026041507721,
-0.21711134910583496,
0.022453688085079193,
0.5339757204055786,
0.18289481103420258,
0.13616201281547546,
0.19849851727485657,
0.2154449224472046,
-0.5157940983772278,
-0.43503519892692566,
-0.16844512522220612,
0.5879982113838196,
-0.0030491745565086603,
0.4750967025756836,
0.6043460965156555,
-0.16767241060733795,
0.05911872535943985,
-0.10484867542982101,
0.11063313484191895,
0.6277827620506287,
0.5868634581565857,
0.1105024591088295,
0.3522212505340576,
0.6963615417480469,
-0.3761720657348633,
0.08040142804384232,
0.38346636295318604,
0.2972719669342041,
0.3789335787296295,
0.02177470549941063,
0.46726974844932556,
0.4560454189777374,
0.524503767490387,
0.017889712005853653,
0.41886213421821594,
0.049577437341213226,
0.5270563960075378,
0.13827821612358093,
-0.6051769256591797,
-0.9009436368942261,
-0.12678270041942596,
0.8841657042503357,
-0.004172667395323515,
-0.21997782588005066,
-0.25113898515701294,
0.1202203556895256,
0.4681096374988556,
-0.23464438319206238,
-0.046407125890254974,
-0.358358770608902,
0.2896569073200226,
0.23170864582061768,
-0.17759943008422852,
-0.3131095767021179,
-0.11189128458499908,
-0.19176673889160156,
0.4046356678009033,
0.31462550163269043,
-0.373431921005249,
-0.868847131729126,
0.36268338561058044,
0.06630659103393555,
0.11067574471235275,
-0.0778479129076004,
-0.14752037823200226,
-0.1435159295797348,
-0.24409468472003937,
0.4166291654109955,
0.016103683039546013,
-0.1084207072854042,
-0.15914466977119446,
-0.507375180721283,
-0.11658161878585815,
-0.6566686034202576,
-0.05006759986281395,
0.36371910572052,
-0.2638126313686371,
0.4087820053100586,
0.1973196268081665,
0.027204226702451706,
0.3559781610965729,
-0.20509617030620575,
-0.09995788335800171,
-0.3516910970211029,
-0.5376471281051636,
-0.09242336452007294,
0.045453887432813644,
-0.36340805888175964,
0.37018024921417236,
0.17724019289016724,
0.04639431834220886,
0.2562970221042633,
-0.18478888273239136,
-0.012718155048787594,
0.4720737040042877,
-0.29763662815093994,
-0.11229363828897476,
-0.2744552791118622,
0.8315718173980713,
0.34325915575027466,
-0.4324200749397278,
-0.06539606302976608,
-0.031521644443273544,
-0.10679904371500015,
0.5153594017028809,
-0.33471280336380005,
0.5388229489326477,
-0.8405702710151672,
-0.5798575282096863,
-0.32544106245040894,
0.2613927721977234,
0.18809790909290314,
-0.3936115503311157,
-0.4971206784248352,
-0.0720028281211853,
0.2544749677181244,
-0.0002915692748501897,
0.6078788042068481,
-0.4933747947216034,
-0.403826504945755,
-0.261236310005188,
-0.14434437453746796,
-0.26441454887390137,
0.5521445870399475,
-0.045367635786533356,
-0.1619867980480194,
0.15516996383666992,
0.024326423183083534,
0.11251257359981537,
-0.15765294432640076,
0.29742905497550964,
-0.4791671335697174,
-0.21908022463321686,
-0.5506166815757751,
0.6493374705314636,
-0.5510363578796387,
-0.03558808192610741,
0.40138816833496094,
0.33808112144470215,
0.5472188591957092,
0.08939886838197708,
-0.47762078046798706,
-0.24531343579292297,
0.38466504216194153,
0.12104034423828125,
0.29855120182037354,
0.35516050457954407,
0.33116286993026733,
-0.5311174988746643,
-0.31380409002304077,
0.291325181722641,
-0.3609986901283264,
-0.2831970453262329,
-0.2038140445947647,
0.1371631920337677,
-0.07667917758226395,
-0.12594568729400635,
-0.2102232277393341,
-0.6869838237762451,
-0.08405956625938416,
-0.2027275115251541
] |
Abstract In order to develop a program for prevention of unwanted pregnancies, we conducted a survey of contraceptive practices and reasons for contraceptive failures of 1520 women seeking abortion at eight large hospitals in Zheng Zhou City, Henan Province, P.R. China, during the period from March 1996 to May 1996. The most frequent cause of the unplanned pregnancy was contraceptive failure (71.9%); 61.7% (938) of these current pregnancies were potentially predictable by virtue of nonuse of contraception (427) or by recognition of contraceptive failures (511). Among the contraceptive failures, the proportion of condom mishaps was the highest (29.7%), next was IUD failures (23.5%), then rhythm miscalculation (15.9%). Most of abortion seekers (77.1%) used some contraceptive methods previously. But, only 19.7% of them used a contraceptive method at the first sexual intercourse. Among 1520 abortion seekers, 57.6% had used condoms previously; 50.9% of the condom users had at least one instance of condom mishap. The rhythm method had been used by 31.7% of abortion seekers previously; 59.1% of the rhythm users had at least one instance of rhythm failure. Of the 16.8% of abortion seekers who had used pills, 58.0% of them had pill failures. Among condom and pill failures, most of them (46.4% condom users and 56.0% pill users) belonged to the user failure category (poor complicance). Of those seeking abortion, 56.4% had experienced at least one instance of previous abortion; 5.3% had experienced previous abortions at least two times. Emergency contraception had been utilized by only 10 subjects prior to this current pregnancy. | [
-0.011816570535302162,
0.025479676201939583,
-0.008032159879803658,
0.021086225286126137,
-0.008513493463397026,
-0.02085212618112564,
0.008412973955273628,
-0.0010144140105694532,
-0.01203598640859127,
-0.021580815315246582,
-0.005882059223949909,
0.006258477456867695,
-0.011129731312394142,
0.003256469499319792,
-0.0207679383456707,
0.0019350606016814709,
-0.008495468646287918,
0.019174888730049133,
0.01050564181059599,
-0.024788863956928253,
0.002964794635772705,
-0.0002442188560962677,
0.008225122466683388,
-0.014134418219327927,
-0.014710807241499424,
0.014104364439845085,
-0.0068006254732608795,
-0.020084800198674202,
0.0037648994475603104,
-0.0060413908213377,
0.014912433922290802,
0.017856089398264885,
0.019690481945872307,
0.021069742739200592,
0.006313333287835121,
-0.002209661528468132,
0.004552237689495087,
0.011777425184845924,
0.014097576960921288,
-0.0032754242420196533,
0.008565828204154968,
-0.014279763214290142,
0.0015073809772729874,
0.003290680004283786,
-0.005764570087194443,
-0.01129014603793621,
-0.003630528226494789,
0.0008792709559202194,
0.0024459040723741055,
0.008649483323097229,
-0.0013030674308538437,
-0.0026478844229131937,
-0.008067858405411243,
0.004909988027065992,
-0.005492396652698517,
-0.020450884476304054,
0.013773476704955101,
-0.015128151513636112,
-0.007068959064781666,
-0.017368322238326073,
-0.017212212085723877,
0.017053864896297455,
-0.004872763995081186,
-0.03555811196565628,
-0.010031596757471561,
-0.06731780618429184,
0.019277043640613556,
0.004743342753499746,
0.004518759436905384,
0.01701614260673523,
-0.0006273912731558084,
-0.0033265971578657627,
-0.018833177164196968,
-0.0017996588721871376,
0.02366938441991806,
-0.009019190445542336,
-0.006701636128127575,
0.002756021451205015,
0.0014370949938893318,
0.01437121257185936,
0.009428399614989758,
-0.020437387749552727,
-0.012721619568765163,
0.012530865147709846,
0.005346662364900112,
-0.008830335922539234,
-0.0049970876425504684,
0.01212382223457098,
0.003668593941256404,
0.013050546869635582,
0.00029488070867955685,
-0.0007980936206877232,
0.013337030075490475,
-0.011849382892251015,
-0.040213655680418015,
-0.01208515278995037,
0.007812243886291981,
-0.05141042172908783,
-0.0066146934404969215,
0.00010619079694151878,
-0.01295369304716587,
0.005938758607953787,
0.01026931032538414,
-0.0008425288833677769,
0.007636948488652706,
0.005807299166917801,
-0.019295647740364075,
-0.01507433969527483,
0.00793913658708334,
-0.0004172267799731344,
-0.004172751680016518,
0.021398931741714478,
0.020388217642903328,
0.00031914288410916924,
0.007374032400548458,
0.014080706983804703,
0.009745449759066105,
0.008033402264118195,
0.010021902620792389,
0.030562154948711395,
0.025349456816911697,
-0.020986488088965416,
-0.012124801054596901,
0.025302201509475708,
-0.0027016685344278812,
0.004491751082241535,
0.014866854064166546,
-0.015495376661419868,
-0.012874857522547245,
-0.003346611512824893,
-0.0054915668442845345,
-0.007179261185228825,
-0.027172841131687164,
-0.006340048275887966,
0.011541006155312061,
0.004477400332689285,
0.022924263030290604,
-0.017957832664251328,
0.001566583989188075,
0.001645892858505249,
0.00962101947516203,
0.00663408637046814,
-0.009385747835040092,
0.010654807090759277,
-0.015355803072452545,
-0.0054565309546887875,
-0.045128654688596725,
0.0211135596036911,
0.014128448441624641,
0.00119657046161592,
-0.01568836346268654,
-0.005176523234695196,
-0.005502990446984768,
-0.0016530377324670553,
-0.02558218315243721,
-0.018403232097625732,
-0.014529068022966385,
-0.007592478301376104,
-0.0014925310388207436,
0.002772795967757702,
-0.014022134244441986,
0.004674525931477547,
-0.01504996232688427,
0.0066816736944019794,
0.032578181475400925,
-0.00304295402020216,
-0.032253049314022064,
0.012215374037623405,
-0.013318678364157677,
0.003220554441213608,
-0.001625256845727563,
-0.018965011462569237,
-0.022999336943030357,
0.013020796701312065,
-0.00020623765885829926,
-0.015403058379888535,
0.011796004138886929,
0.007630256004631519,
-0.006747385021299124,
0.06676097959280014,
0.0031824866309762,
0.0004838057793676853,
-0.006141998805105686,
0.0007441638736054301,
0.001937058288604021,
-0.0068328361958265305,
0.016368385404348373,
-0.006000630557537079,
0.014707561582326889,
-0.010358747094869614,
0.02863457426428795,
-0.014121096581220627,
0.0026217710692435503,
0.006335794925689697,
-0.00251398840919137,
0.004268665798008442,
0.004657783079892397,
0.00536699453368783,
-0.0038123365957289934,
0.0048513710498809814,
-0.023250650614500046,
0.01360233686864376,
-0.006823001895099878,
-0.024979501962661743,
0.0013627265579998493,
0.009294544346630573,
0.00688824150711298,
-0.0037140795029699802,
-0.0016029474791139364,
-0.008541124872863293,
0.00036255968734622,
0.0035072998143732548,
0.014301449991762638,
-0.0017061580438166857,
0.01680814102292061,
0.0021581421606242657,
0.004544330760836601,
0.026179930195212364,
-0.03663007915019989,
-0.011193799786269665,
-0.0011928220046684146,
0.014914993196725845,
0.015991918742656708,
-0.013848266564309597,
0.005646388046443462,
-0.010834451764822006,
0.017022065818309784,
0.005020838230848312,
0.007152915000915527,
0.008377807214856148,
-0.013219556771218777,
-0.018696649000048637,
-0.005816802382469177,
0.0015340375248342752,
0.020263278856873512,
-0.0152294235303998,
0.01046803779900074,
-0.017352474853396416,
0.008961018174886703,
-0.017092056572437286,
0.0016320552676916122,
0.012858910486102104,
0.02069971337914467,
0.01743169128894806,
0.012010428123176098,
-0.023573599755764008,
0.012301668524742126,
0.011865200474858284,
-0.02104346826672554,
-0.004365801811218262,
0.007564479019492865,
-0.022008346393704414,
-0.004872170742601156,
0.00558844767510891,
0.02647807076573372,
-0.003451091004535556,
-0.0009501082822680473,
0.0003979806788265705,
0.024439295753836632,
-0.01978675089776516,
0.02065882459282875,
0.008391675539314747,
-0.0046194493770599365,
-0.0212384220212698,
-0.01385108195245266,
-0.0232800655066967,
0.010728424414992332,
0.014265148900449276,
0.01049087569117546,
0.02735227532684803,
0.009119994938373566,
-0.010192081332206726,
-0.006430559791624546,
-0.08223949372768402,
-0.010140134021639824,
0.002386095467954874,
-0.017091842368245125,
-0.0002908388269133866,
0.02570946142077446,
0.0016638946253806353,
0.002628820948302746,
-0.00023086974397301674,
-0.002882497850805521,
0.017474273219704628,
-0.008156338706612587,
-0.0025383122265338898,
0.025832191109657288,
0.02285159006714821,
-0.0031646862626075745,
0.003908997401595116,
0.022291887551546097,
-0.016208535060286522,
-0.01613323763012886,
0.010620182380080223,
-0.04557553306221962,
0.0035200733691453934,
-0.00284745916724205,
-0.024436773732304573,
0.02557656727731228,
0.0026510953903198242,
-0.0049454825930297375,
-0.013580814935266972,
0.006685649510473013,
0.00231632380746305,
-0.0014038034714758396,
-0.008237474597990513,
-0.007361645344644785,
0.007311606779694557,
-0.000036716111935675144,
-0.013652723282575607,
0.0015415565576404333,
-0.014892532490193844,
-0.011233393102884293,
0.001684473711065948,
0.0029044081456959248,
0.004440460354089737,
0.004824744537472725,
-0.004451517481356859,
0.00022203498519957066,
0.0017795036546885967,
0.03046422265470028,
0.016501963138580322,
0.008838226087391376,
-0.010602540336549282,
-0.00844127032905817,
0.022091327235102654,
0.00572968740016222,
-0.006574714556336403,
-0.002375134965404868,
0.006164559628814459,
-0.018404178321361542,
-0.006708436645567417,
-0.007655825465917587,
-0.01767965406179428,
-0.007732377387583256,
-0.0034000540617853403,
0.006354703102260828,
-0.023466259241104126,
0.0017891207244247198,
0.02315768226981163,
0.007914029061794281,
0.0011767892865464091,
-0.011684691533446312,
0.006953551433980465,
0.005770741030573845,
-0.005410186015069485,
-0.015417661517858505,
0.004885755013674498,
0.0034742511343210936,
-0.014263567514717579,
0.0030858959071338177,
0.004220360890030861,
-0.0016179860103875399,
-0.017654873430728912,
-0.007738981395959854,
-0.007953132502734661,
0.022430025041103363,
-0.0017366872634738684,
-0.014308735728263855,
0.018855862319469452,
-0.002617279067635536,
0.014853743836283684,
-0.016690602526068687,
0.008235965855419636,
0.031687669456005096,
-0.01866128109395504,
0.011189344339072704,
-0.014389432035386562,
-0.005285888910293579,
-0.0023136544041335583,
-0.016677943989634514,
-0.013925750739872456,
0.007452963851392269,
-0.011315945535898209,
-0.0024058253038674593,
-0.005691354162991047,
-0.008773318491876125,
-0.01705934666097164,
0.008089443668723106,
0.012366159819066525,
-0.024551458656787872,
-0.003571833251044154,
-0.001300581730902195,
-0.023467175662517548,
0.009398655965924263,
-0.0006616426398977637,
0.009248839691281319,
0.009834186173975468,
0.007341279648244381,
0.00792698934674263,
0.017905253916978836,
0.07294754683971405,
-0.02241838537156582,
0.020933393388986588,
-0.012938226573169231,
-0.012129684910178185,
-0.01720350980758667,
0.0037183836102485657,
0.0019424937199801207,
0.04689033702015877,
-0.006763628218322992,
0.012224641628563404,
-0.04797594994306564,
0.009367930702865124,
-0.007991636171936989,
0.00005458202213048935,
0.006401970051229,
-0.02867574617266655,
-0.004467392805963755,
-0.019936196506023407,
0.010881285183131695,
-0.020303038880228996,
0.007834474556148052,
0.007282138802111149,
0.02028784714639187,
-0.010241804644465446,
0.010712933726608753,
-0.0018450263887643814,
-0.010556526482105255,
-0.01457381434738636,
0.004848171956837177,
-0.017857585102319717,
0.02213597297668457,
-0.004742562770843506,
-0.021394090726971626,
-0.004389853682368994,
-0.014240827411413193,
-0.000010925112292170525,
-0.01852864772081375,
-0.00913870707154274,
-0.008251763880252838,
0.03433270752429962,
-0.014387068338692188,
0.004962492268532515,
0.0026317699812352657,
0.004314943216741085,
0.0023371477145701647,
0.007449221797287464,
-0.009784398600459099,
0.001156891928985715,
-0.00030332221649587154,
-0.0017959375400096178,
-0.0014540504198521376,
0.008158354088664055,
-0.030256282538175583,
0.020276501774787903,
-0.012498843483626842,
-0.02783529832959175,
-0.0026261811144649982,
-0.007960498332977295,
-0.01481604389846325,
0.018674302846193314,
-0.014475862495601177,
0.021634232252836227,
-0.013001758605241776,
-0.0079564917832613,
-0.007001028396189213,
-0.01734454184770584,
-0.0017395513132214546,
-0.00474883895367384,
0.010311850346624851,
-0.0052077677100896835,
0.01085241511464119,
0.010547171346843243,
-0.012211916036903858,
0.005003804340958595,
0.009990978054702282,
0.002047301735728979,
-0.0020003169775009155,
0.0038471720181405544,
-0.017580736428499222,
-0.012997865676879883,
-0.010318934917449951,
-0.014880859293043613,
-0.0004634307697415352,
0.02683117426931858,
-0.004241646733134985,
-0.012882158160209656,
-0.07600138336420059,
-0.011160118505358696,
-0.008425386622548103,
-0.007340302690863609,
0.0006142256315797567,
0.002994310576468706,
-0.015859421342611313,
0.01757158525288105,
-0.029539719223976135,
-0.00894515123218298,
-0.004013221710920334,
-0.020223431289196014,
-0.01402237731963396,
-0.009307613596320152,
0.014833572320640087,
-0.01175722200423479,
0.0012958066072314978,
0.00993009377270937,
-0.003413560101762414,
0.007399125024676323,
0.022985251620411873,
-0.017513973638415337,
-0.019655605778098106,
-0.014832153916358948,
0.003919409587979317,
-0.08183805644512177,
0.004752738866955042,
0.006132390350103378,
-0.0019538754131644964,
-0.00033419893588870764,
-0.01898321509361267,
-0.002661227947100997,
-0.009095723740756512,
0.01843109354376793,
-0.011502206325531006,
0.0035943100228905678,
0.0023113684728741646,
0.01384306326508522,
-0.01965145766735077,
0.007689181715250015,
-0.008526402525603771,
0.020253315567970276,
-0.010863497853279114,
-0.020124394446611404,
0.03438063710927963,
-0.0036127185449004173,
-0.02649121731519699,
-0.003701401874423027,
-0.014132189564406872,
-0.005914886482059956,
0.0046999044716358185,
-0.0016818935982882977,
0.00439136428758502,
0.007550036534667015,
0.008206211030483246,
-0.014840224757790565,
0.0026787882670760155,
0.002908390248194337,
-0.02329622395336628,
0.004923918284475803,
-0.0027365083806216717,
0.015072636306285858,
-0.013360770419239998,
0.03335191681981087,
-0.0034688892774283886,
-0.007101963274180889,
0.005614172667264938,
0.0026726252399384975,
-0.004073900170624256,
0.021408751606941223,
0.0019867373630404472,
0.006139586679637432,
-0.012976499274373055,
0.02333049848675728,
-0.0031467205844819546,
0.010685881599783897,
-0.007743132766336203,
-0.013106988742947578,
-0.0058730789460241795,
-0.001434830017387867,
-0.027633972465991974,
-0.0013793745310977101,
0.0020263090264052153,
0.017236903309822083,
0.008233700878918171,
0.015350110828876495,
0.021095389500260353,
-0.033690690994262695,
0.07186074554920197,
-0.017148083075881004,
-0.004612912889569998,
-0.023877833038568497,
-0.0014918711967766285,
0.0017408542335033417,
0.008388390764594078,
-0.009354175999760628,
-0.017792094498872757,
0.011428389698266983,
-0.009500063955783844,
-0.005931762978434563,
-0.000007016933523118496,
0.007520602084696293,
0.023269984871149063,
0.015019390732049942,
-0.0036366074346005917,
-0.010460086166858673,
0.0064255003817379475,
0.0023802421055734158,
0.014982813969254494,
0.021744322031736374,
0.008172932080924511,
-0.002813683357089758,
0.0014060428366065025,
0.003503293264657259,
-0.018819835036993027,
0.011703803203999996,
-0.0007366579957306385,
-0.00032758794259279966,
-0.012774666771292686,
0.02058493159711361,
0.009741726331412792,
0.001002263044938445,
0.0017879782244563103,
-0.017601000145077705,
0.01710185967385769,
0.004125095438212156,
0.009126752614974976,
0.03101540356874466,
0.0018044575117528439,
0.004423737525939941,
0.007537056691944599,
-0.002594524994492531,
0.008269469253718853,
-0.0186346173286438,
0.001976780593395233,
-0.012439717538654804,
-0.006720225792378187,
0.022923380136489868,
-0.01020725630223751,
0.009365430101752281,
0.002045092172920704,
-0.004129804205149412,
0.0016903842333704233,
-0.03231357783079147,
-0.009461530484259129,
0.014390397816896439,
0.0037606777623295784,
0.027890298515558243,
0.001990114338696003,
-0.0032498298678547144,
0.0329863540828228,
-0.010166704654693604,
0.019187849014997482,
-0.012788111343979836,
-0.002454649657011032,
-0.008382629603147507,
0.027853116393089294,
0.006522987969219685,
-0.006208977662026882,
0.010398099198937416,
0.006154254078865051,
0.00646052835509181,
0.004126779735088348,
0.018578369170427322,
0.01751670055091381,
-0.005502458196133375,
0.008708355017006397,
0.009998558089137077,
-0.006623788736760616,
0.0427587553858757,
0.006170892156660557,
-0.022398171946406364,
-0.011735324747860432,
-0.0071394070982933044,
0.024593055248260498,
-0.0024194936268031597,
-0.011228651739656925,
-0.00009474426042288542,
-0.008707054890692234,
0.00015066907508298755,
0.005071959458291531,
-0.01267835684120655,
0.011195572093129158,
0.03518577665090561,
0.0034804176539182663,
0.0030834488570690155,
0.017976250499486923,
-0.005889088846743107,
0.010280909948050976,
-0.01911117322742939,
-0.013129166327416897,
-0.016867080703377724,
-0.005382481962442398,
-0.0015375816728919744,
0.01638067327439785,
-0.0032829809933900833,
0.017330419272184372,
0.02236090414226055,
0.005610266700387001,
-0.008828021585941315,
0.003996666055172682,
0.01465192623436451,
0.013157189823687077,
0.027495872229337692,
-0.004350690171122551,
-0.010509936138987541,
0.010366933420300484,
-0.011163071729242802,
-0.006868415977805853,
0.0010285882744938135,
-0.008550001308321953,
0.024402910843491554,
-0.009349077008664608,
-0.021736839786171913,
-0.005808332469314337,
0.0248375553637743,
0.0033011185005307198,
0.005669749341905117,
0.013289039023220539,
0.0013252111384645104,
-0.0008651199750602245,
0.009010788053274155,
-0.022207487374544144,
0.010831702500581741,
0.0009796234080567956,
0.012220832519233227,
-0.018474390730261803,
0.0008082166314125061,
-0.0220513716340065,
0.00437413714826107,
0.007486186921596527,
-0.00745413638651371,
0.007909141480922699,
-0.015151109546422958,
-0.002012866549193859,
0.034646473824977875,
0.01852940395474434,
-0.015452207997441292,
-0.00925153587013483,
0.02349698543548584,
0.027402125298976898,
-0.0062695094384253025,
0.012508058920502663,
0.003539619967341423,
0.013217390514910221,
-0.037476520985364914,
0.013462233357131481,
0.0019615073688328266,
-0.005913029424846172,
-0.038562141358852386,
-0.010097328573465347,
-0.0007395991124212742,
0.005828316789120436,
0.027473770081996918,
0.004149347543716431,
-0.004374435171484947,
-0.010002395138144493,
0.0002457748632878065,
0.01433476246893406,
0.002844925969839096,
-0.02917773462831974,
0.017274683341383934,
-0.016230270266532898,
-0.005148256663233042,
0.0023103696294128895,
-0.01407899335026741,
-0.0010188962332904339,
0.009549248963594437,
0.001666772412136197,
0.01662135310471058,
0.00797818973660469,
-0.008412418887019157,
-0.017181336879730225,
0.002404618775472045,
-0.005843114107847214,
-0.023462660610675812,
0.007091747596859932,
0.007528793998062611,
-0.009386665187776089,
-0.0052176788449287415,
-0.010641426779329777,
0.0046963803470134735,
-0.0036790769081562757,
-0.0127570116892457,
0.008710235357284546,
-0.013008510693907738,
-0.003900718642398715,
0.006590770557522774,
0.026651624590158463,
0.005069589242339134
] | [
0.4044272005558014,
0.12079548090696335,
0.26808908581733704,
-0.1008472815155983,
0.03286029398441315,
0.9562558531761169,
0.0735086053609848,
-0.2596416771411896,
-0.18855249881744385,
-0.2928276062011719,
0.48326951265335083,
0.051801905035972595,
0.019505487754940987,
0.2598308026790619,
-0.21851496398448944,
0.6371462941169739,
0.32922786474227905,
0.34558939933776855,
-0.30217599868774414,
-0.5368936657905579,
-0.24287113547325134,
-0.5735220313072205,
0.0037272272165864706,
0.46140649914741516,
0.09158752858638763,
0.10916801542043686,
0.5202586650848389,
-0.2295311540365219,
-0.18242739140987396,
0.023534435778856277,
-0.05370975658297539,
0.10108458995819092,
0.4726242125034332,
-0.32510948181152344,
0.05753814056515694,
0.08375179022550583,
-0.21414202451705933,
-0.1613500863313675,
-0.18605399131774902,
-0.2886289358139038,
-0.4620778560638428,
-0.26365169882774353,
-0.025166930630803108,
0.5945509076118469,
-0.24119701981544495,
-0.39148369431495667,
-1.3848987817764282,
0.646719753742218,
-0.2717002332210541,
0.21629315614700317,
-0.2489631026983261,
0.23177020251750946,
0.38963252305984497,
0.31812357902526855,
0.04937038570642471,
0.4834343194961548,
0.29188966751098633,
-0.043180130422115326,
-0.2668451964855194,
-0.375874400138855,
0.6077880263328552,
0.19844597578048706,
0.4101588726043701,
0.5151902437210083,
-0.10354945063591003,
0.4466664791107178,
-0.02543216198682785,
0.42750680446624756,
-0.2364812046289444,
-0.1962893009185791,
-0.17637206614017487,
0.09940728545188904,
-0.7341326475143433,
-0.015176705084741116,
-0.17446106672286987,
-0.019105153158307076,
-0.4413769841194153,
-0.4282332956790924,
0.4073677957057953,
0.028255030512809753,
0.030735991895198822,
0.5028079152107239,
0.5242943167686462,
-0.5734316110610962,
0.42272451519966125,
0.11003304272890091,
-0.02074095420539379,
0.5688692927360535,
-0.04498035088181496,
-0.20179162919521332,
-0.1494891196489334,
-0.2816201448440552,
0.23919832706451416,
0.34774506092071533,
-0.19731156527996063,
0.19629307091236115,
0.009927848353981972,
-0.24912360310554504,
0.21132728457450867,
-0.10886554419994354,
0.3663102686405182,
0.20556505024433136,
-0.1390393078327179,
0.00046848959755152464,
-0.6218214631080627,
-0.3440713584423065,
0.19328249990940094,
-0.9512457251548767,
0.03834225609898567,
-0.02224043384194374,
-0.5047562122344971,
0.7034128904342651,
0.03803921490907669,
-0.796985387802124,
-0.31931719183921814,
0.32124507427215576,
0.18633058667182922,
-0.08762748539447784,
-0.16003301739692688,
0.21432827413082123,
-0.37946727871894836,
0.058824289590120316,
-0.10545641928911209,
0.07006967812776566,
0.41988447308540344,
0.31994742155075073,
0.46024277806282043,
0.01605113036930561,
-0.43286043405532837,
0.2441616803407669,
-0.03763243556022644,
0.14693309366703033,
-0.1603928953409195,
0.02037082239985466,
0.13122208416461945,
-0.5130195617675781,
0.1259576678276062,
0.163284033536911,
0.574172854423523,
0.17571566998958588,
-0.7313957810401917,
0.2774941325187683,
-0.5602211952209473,
-0.1688850075006485,
0.3420831561088562,
-0.3094334900379181,
0.017612334340810776,
-0.09733733534812927,
-0.2733236849308014,
-0.25329136848449707,
-0.13408686220645905,
-0.2531348168849945,
0.04813045635819435,
-0.40361398458480835,
0.11758168786764145,
0.054805051535367966,
-0.5079730153083801,
0.13107410073280334,
0.05162614956498146,
-0.09000032395124435,
0.6711781024932861,
0.7375825643539429,
-0.2448509931564331,
0.02479417808353901,
-0.053785402327775955,
-0.3267735242843628,
0.5045390725135803,
0.061460185796022415,
0.42889028787612915,
-0.09833204746246338,
-0.44294658303260803,
-0.3798803389072418,
0.13300643861293793,
-0.006362296175211668,
-0.46670734882354736,
-0.024007277563214302,
0.5112109184265137,
-0.08099857717752457,
0.15174594521522522,
0.12858794629573822,
-0.6384111642837524,
-0.07625779509544373,
0.33226197957992554,
-0.014670215547084808,
-0.007910453714430332,
-0.3337460458278656,
0.09117118269205093,
0.01627453789114952,
0.18332913517951965,
0.4838012456893921,
-0.2314710021018982,
-0.6277908682823181,
0.5923619866371155,
-0.4575746953487396,
0.7995218634605408,
-0.21873821318149567,
-0.7693839073181152,
1.1550145149230957,
-0.25743260979652405,
-0.11369072645902634,
-0.14243020117282867,
0.11487923562526703,
0.5023165941238403,
-0.02594083733856678,
-0.5050966143608093,
-0.17188675701618195,
0.10193344950675964,
-0.04929282143712044,
-0.5485122203826904,
0.04611562564969063,
-0.09596090018749237,
-0.1665506809949875,
-0.2512543499469757,
-0.08892879635095596,
0.04206893593072891,
0.39898568391799927,
0.20955219864845276,
0.2940191328525543,
0.0697258710861206,
0.19175341725349426,
0.7316232323646545,
-0.5442537069320679,
0.06341344863176346,
0.26868435740470886,
0.12280957400798798,
0.5484503507614136,
0.6939350366592407,
0.19838909804821014,
0.4077884554862976,
-0.3422410786151886,
-0.08895789086818695,
0.06256531178951263,
0.39600852131843567,
0.023996755480766296,
-0.18087750673294067,
0.35820797085762024,
-0.295138955116272,
-0.05933214724063873,
-0.1355469822883606,
0.24610288441181183,
0.18975700438022614,
0.25065863132476807,
-0.2881670594215393,
0.19500039517879486,
0.1291566789150238,
-0.19837674498558044,
-0.3687193691730499,
0.3571005165576935,
-0.10449942201375961,
0.08010457456111908,
0.052587464451789856,
0.2550261318683624,
0.22460150718688965,
0.09891261160373688,
-0.4581509530544281,
0.17766596376895905,
0.0022645490244030952,
-0.06609120965003967,
1.21216881275177,
0.24015967547893524,
0.4541008174419403,
-0.009093394502997398,
0.4580729603767395,
0.02497304603457451,
0.3963644802570343,
-0.432757705450058,
-0.3623225688934326,
-0.665073812007904,
0.17374533414840698,
0.26269152760505676,
0.4001239240169525,
0.3158371150493622,
-0.6475757956504822,
0.3067632019519806,
-0.253047913312912,
-0.6473603844642639,
-0.008572551421821117,
0.43590596318244934,
-0.9575894474983215,
-0.6303195953369141,
0.11302696168422699,
0.05890468508005142,
0.6974188685417175,
-0.19855161011219025,
0.2920292317867279,
0.19209632277488708,
0.012791421264410019,
-0.2472618669271469,
0.029704872518777847,
-0.21945610642433167,
-0.06995771080255508,
0.45014020800590515,
-0.33286330103874207,
-0.6301558613777161,
0.48794591426849365,
0.08589696139097214,
-0.13694968819618225,
0.013641773723065853,
0.6547958850860596,
0.07842953503131866,
0.33753371238708496,
0.1831860989332199,
-0.20249374210834503,
-0.011984352953732014,
0.22996068000793457,
0.09145811200141907,
0.25545066595077515,
0.12983915209770203,
-6.2016706466674805,
0.0695340558886528,
-0.28357356786727905,
-0.40438568592071533,
-0.026980364695191383,
0.32483890652656555,
0.6384093761444092,
-0.12143443524837494,
0.3088928759098053,
0.09561821818351746,
0.0022748701740056276,
0.030576100572943687,
0.15512429177761078,
0.25382956862449646,
-0.19254626333713531,
0.23956425487995148,
0.4241096079349518,
-0.0885644257068634,
0.23138365149497986,
0.23867350816726685,
0.1606404334306717,
-0.37752288579940796,
0.1497182548046112,
0.5367825627326965,
0.4524368643760681,
0.37624049186706543,
-0.9797282814979553,
-0.03699908033013344,
0.03062056377530098,
-0.1362522542476654,
0.02369975484907627,
-0.7271115183830261,
-0.14061209559440613,
0.15785647928714752,
-0.06831733137369156,
0.28986936807632446,
0.6515305042266846,
-0.33255675435066223,
0.30201029777526855,
-0.39817726612091064,
0.010195747949182987,
0.17520684003829956,
-0.05392550304532051,
-0.2683236598968506,
0.008724873885512352,
-0.36187463998794556,
-0.17440687119960785,
0.03908177837729454,
-0.41646939516067505,
0.41584309935569763,
0.19323183596134186,
0.20138239860534668,
0.3156885504722595,
0.5717171430587769,
-0.281376451253891,
0.2744726240634918,
-0.486998051404953,
0.4707573354244232,
-0.6241112351417542,
0.10888085514307022,
0.1759568303823471,
0.17381221055984497,
0.31844937801361084,
-0.9870787858963013,
-0.10117444396018982,
-0.1460362672805786,
-0.26266250014305115,
-0.005598205141723156,
-0.22761158645153046,
0.4469437897205353,
-0.5680281519889832,
0.30201318860054016,
0.2523029148578644,
-0.842068076133728,
0.49182164669036865,
-0.5785074234008789,
-0.12402578443288803,
-0.29882052540779114,
-0.21976254880428314,
-0.2745336592197418,
-0.21163038909435272,
-0.5408375263214111,
0.5014563202857971,
0.5139639377593994,
-0.06339412927627563,
0.029030272737145424,
0.22189073264598846,
-0.17147018015384674,
-0.3781505227088928,
-0.019253475591540337,
0.7972837090492249,
-0.01661664992570877,
0.19755539298057556,
0.3285678029060364,
0.130703404545784,
0.5223975777626038,
0.13419756293296814,
0.013030465692281723,
0.45630794763565063,
0.17622339725494385,
0.34327125549316406,
0.14678381383419037,
-0.23292438685894012,
-0.8427547812461853,
-0.5225172638893127,
-0.1700860559940338,
-0.4793333113193512,
-0.17641474306583405,
0.7401431202888489,
-0.629906177520752,
-0.38636869192123413,
0.4926284849643707,
0.20500384271144867,
-0.4804275333881378,
0.3180357813835144,
0.1255805343389511,
0.09314289689064026,
-0.12989826500415802,
0.4217645823955536,
0.10236133635044098,
0.024217506870627403,
-0.12264854460954666,
-0.5413770079612732,
-0.11740562319755554,
0.3404170870780945,
-0.4005921483039856,
0.24426670372486115,
0.22749285399913788,
-0.46864429116249084,
0.009093664586544037,
0.18685735762119293,
0.20019219815731049,
-0.31950822472572327,
0.01597527042031288,
-0.09503941237926483,
-0.30000853538513184,
-0.4561912417411804,
0.12699535489082336,
-0.10617569833993912,
0.3632073700428009,
0.3901481628417969,
0.19611282646656036,
-0.6995118260383606,
-0.17657190561294556,
-0.015490044839680195,
0.15645767748355865,
-0.10200635343790054,
-0.10722604393959045,
-0.40085819363594055,
-0.12254520505666733,
-0.04512852430343628,
-0.4656616747379303,
0.7845228314399719,
0.17334546148777008,
-0.47865357995033264,
0.1661149114370346,
0.5074355602264404,
0.18229350447654724,
-0.5297839641571045,
-0.17720972001552582,
0.09489084780216217,
-0.03510773554444313,
-0.7295921444892883,
-0.09456198662519455,
0.03955056145787239,
0.32314828038215637,
0.6631110310554504,
-0.14700475335121155,
0.222808837890625,
0.4331061542034149,
0.53037428855896,
-0.21093161404132843,
-0.009076695889234543,
0.38389483094215393,
0.20029807090759277,
0.04647649824619293,
-0.33981195092201233,
-0.4068276286125183,
0.10686322301626205,
0.18070390820503235,
0.07590366899967194,
-0.2244960516691208,
0.3577190637588501,
0.23553723096847534,
0.6705876588821411,
0.06980109214782715,
-0.15522980690002441,
-0.24089927971363068,
-0.20449376106262207,
0.24906949698925018,
0.18607336282730103,
0.19132862985134125,
0.5697382092475891,
0.05327456071972847,
-0.17085959017276764,
-0.10080337524414062,
0.045767005532979965,
0.293142169713974,
-0.35084453225135803,
0.33243677020072937,
-0.030818751081824303,
-0.20244048535823822,
-0.16042275726795197,
0.4377121329307556,
0.24052777886390686,
-0.5393850207328796,
-0.55240398645401,
-0.2855823040008545,
0.11107157170772552,
-0.3206087052822113,
-0.2596292793750763,
-0.15501125156879425,
-0.5164353251457214,
-0.05524880439043045,
-0.38083067536354065,
0.38402941823005676,
-0.40869390964508057,
-0.6022799611091614,
-0.2888208329677582,
0.37464961409568787,
-0.2860684394836426,
-0.18132632970809937,
-0.326099693775177,
-0.044142719358205795,
0.2335413545370102,
0.24408668279647827,
0.5145924687385559,
-0.8039343953132629,
-0.10422021895647049,
0.046367812901735306,
-0.4256809949874878,
0.5055262446403503,
0.18796980381011963,
0.08340669423341751,
-0.6700837016105652,
-0.4493316113948822,
-0.07859311252832413,
-0.2005956619977951,
-0.17983661592006683,
0.088777095079422,
-0.25733157992362976,
0.3369481563568115,
-0.2552792727947235,
-0.3139399588108063,
0.4583578109741211,
-0.0626264214515686,
0.07135869562625885,
-0.4925607144832611,
-0.3762773871421814,
0.47162845730781555,
0.06248338893055916,
-0.6039419770240784,
0.1262500286102295,
-0.709473729133606,
0.0010231308406218886,
-0.3276605010032654,
-0.16408976912498474,
-0.040821291506290436,
0.1405060887336731,
0.11514812707901001,
-0.3769989013671875,
-0.4760362505912781,
-0.3294605016708374,
-0.18873946368694305,
-0.04887441173195839,
0.05242137238383293,
-0.061120111495256424,
-0.3421705365180969,
0.261057585477829,
-0.35510513186454773,
-0.1135643944144249,
-0.02456490695476532,
0.20895427465438843,
0.19548656046390533,
0.12931112945079803,
-0.357082724571228,
-0.14163339138031006,
0.06680941581726074,
-0.06191044673323631,
-0.2763987183570862,
-0.4611641466617584,
-0.295572429895401,
0.10794559866189957,
-0.10939181596040726,
0.6190219521522522,
-0.6351044178009033,
0.1444704681634903,
-0.11791449040174484,
-0.5554805397987366,
-0.22848030924797058,
-0.051594000309705734,
0.3565596342086792,
-0.5171297788619995,
-0.545924186706543,
-0.2962380647659302,
0.1994214802980423,
0.29203295707702637,
0.30851390957832336,
-0.21916532516479492,
-0.5021722316741943,
-0.19542951881885529,
-0.013305912725627422,
0.620322585105896,
0.0843280628323555,
-0.6607339978218079,
-0.29656100273132324,
0.36015209555625916,
-0.08588381111621857,
-0.37213724851608276,
0.5847413539886475,
0.5115046501159668,
0.04545419663190842,
0.49946317076683044,
0.5355610847473145,
-0.8430207371711731,
0.13075770437717438,
-0.9022853970527649,
-0.5277906060218811,
0.340652734041214,
0.22079011797904968,
0.05910881608724594,
0.6256315112113953,
0.16869810223579407,
0.08041338622570038,
-0.296929270029068,
0.28407779335975647,
0.15524822473526,
0.6422874927520752,
-0.20596571266651154,
0.03594021126627922,
0.2015807330608368,
0.08941429108381271,
0.1877618432044983,
0.06701004505157471,
0.23799197375774384,
-0.1020289957523346,
0.00871990341693163,
-0.7151700854301453,
-0.053366318345069885,
0.22707287967205048,
0.7523427605628967,
0.5991384387016296,
-0.2542031705379486,
-0.06760857999324799,
0.2885623872280121,
0.3784194588661194,
-0.2612476050853729,
0.3586120307445526,
0.31956225633621216,
0.0971081405878067,
0.23808357119560242,
-0.09459321200847626,
-0.4949961304664612,
0.007174418307840824,
-0.1664518415927887,
0.42508479952812195,
0.16507934033870697,
-0.20662221312522888,
-0.0980396494269371,
0.3426816463470459,
-0.15803977847099304,
0.38100966811180115,
-0.02895185351371765,
-0.2820456624031067,
0.0646246150135994,
-0.05864248424768448,
0.680117666721344,
-0.07481977343559265,
-0.03681609034538269,
-0.1010899767279625,
0.46922028064727783,
0.01854272000491619,
-0.5562199354171753,
-0.3368087112903595,
-0.07884985208511353,
0.10996297001838684,
0.17004449665546417,
-0.08467654138803482,
-0.3442683219909668,
0.45746415853500366,
0.05876666307449341,
-0.02950115129351616,
0.03140229359269142,
-0.34877729415893555,
-0.42337334156036377,
-0.17832915484905243,
-0.07086662203073502,
0.028043415397405624,
0.15966719388961792,
0.09678280353546143,
0.16537833213806152,
-0.1977616548538208,
0.17043378949165344,
0.28333303332328796,
0.07374034076929092,
-0.1494206041097641,
-0.023456387221813202,
0.4559389054775238,
0.33250126242637634,
0.6155713796615601,
-0.44822177290916443,
-0.3090049922466278,
-0.11907253414392471,
0.219436377286911,
-0.1709524393081665,
0.333692729473114,
-0.3956235647201538,
-0.005646594800055027,
-0.49219074845314026,
0.00017790409037843347,
0.5401533246040344,
0.49940603971481323,
-0.05217808485031128,
0.40378519892692566,
0.2959507405757904,
-0.17240391671657562,
0.8915723562240601,
-0.30665478110313416,
-0.4065783619880676,
-0.25192806124687195,
-0.4430418312549591,
-0.5112866759300232,
-0.07525025308132172,
0.02934242971241474,
-0.49849578738212585,
0.09884059429168701,
0.3232001066207886,
0.00775163946673274,
-0.06249821558594704,
0.4825369417667389,
-0.6137785315513611,
-0.34736722707748413,
-0.5784338712692261,
0.20363177359104156,
-0.5624047517776489,
0.2638143002986908,
0.1816442906856537,
0.1908959299325943,
0.33854031562805176,
-0.1525297462940216,
-0.011525282636284828,
0.020698802545666695,
-0.4218940734863281,
-0.03798428177833557,
0.40480369329452515,
0.5815461874008179,
0.09804888069629669,
-0.06292728334665298,
-0.01399394404143095,
0.2842903137207031,
-0.2809697389602661,
0.2040884643793106,
0.10926145315170288,
-0.3659345209598541,
-0.030741743743419647,
-0.44950541853904724,
-0.0662025436758995,
-0.5258031487464905,
0.022929053753614426,
0.12811319530010223
] |
To determine physicians' perceptions of the effects that the companions of cancer patients have on physician-patient communication, semistructured interviews were conducted with 12 oncologists (6 medical, 4 surgical, and 2 radiation) from a total population of 21 oncologists. The physicians estimated that threefourths of their patients brought companions with them to consultations and said that these consultations were more complex for the physician. The behaviors of the companions varied from domination to passive note taking, and the companions who were young professional men or older women who accompanied their husbands were the most assertive and asked the most questions. All possible coalitions were observed during medical visits. The physicians perceived that companions and patients often had different agendas and noted differences in the companions' behaviors according to their gender and whether they lived in rural or urban areas. | [
0.011228881776332855,
0.021662645041942596,
-0.017522120848298073,
0.021126359701156616,
-0.007023664657026529,
-0.0185907781124115,
0.009456703439354897,
-0.028975995257496834,
-0.01703576371073723,
-0.027209866791963577,
0.004653049632906914,
0.023527052253484726,
0.015809595584869385,
0.015491222031414509,
-0.00416212435811758,
-0.01454969123005867,
-0.030223680660128593,
-0.02462627738714218,
0.0034584493841975927,
0.012523123994469643,
0.016827601939439774,
0.00771188922226429,
0.010317627340555191,
0.017772303894162178,
-0.03233438357710838,
0.03040303662419319,
-0.001446818932890892,
0.014281824231147766,
0.01899266056716442,
0.009963646531105042,
-0.019036168232560158,
0.004232669249176979,
0.011150142177939415,
-0.007280381862074137,
0.019764557480812073,
-0.040046144276857376,
0.005643702577799559,
0.02206934615969658,
-0.014256155118346214,
-0.004152746871113777,
0.009571289643645287,
-0.0024481997825205326,
-0.008467843756079674,
-0.002396104857325554,
-0.005772007163614035,
0.03116624988615513,
-0.013203405775129795,
0.0044304383918643,
0.001657593180425465,
0.010513260960578918,
-0.0011197535786777735,
0.002149441745132208,
-0.019013676792383194,
-0.007454711943864822,
-0.0068637351505458355,
0.009090138599276543,
0.02017422392964363,
-0.007252749055624008,
0.002128325402736664,
-0.015942905098199844,
-0.001524834311567247,
-0.0051230755634605885,
0.02736930549144745,
-0.012024203315377235,
-0.014256130903959274,
-0.06701600551605225,
0.008372524753212929,
-0.020044870674610138,
-0.010099304839968681,
-0.006678011268377304,
-0.00008625746704638004,
0.01635833829641342,
-0.00008303113281726837,
-0.016728036105632782,
-0.02605845034122467,
0.019522584974765778,
0.011926203966140747,
-0.006120856385678053,
0.03534088283777237,
0.017170310020446777,
-0.010675722733139992,
0.012093390338122845,
-0.0464201420545578,
0.015985552221536636,
0.019609306007623672,
0.01816273294389248,
-0.00003848085179924965,
0.013063205406069756,
0.0008270293474197388,
0.037522099912166595,
0.023869343101978302,
0.00204258831217885,
0.01867036148905754,
-0.015828054398298264,
-0.011582409031689167,
0.013927171006798744,
-0.00967103336006403,
-0.0008484832942485809,
0.014390847645699978,
0.006561449728906155,
0.0026549436151981354,
0.019033875316381454,
0.025483019649982452,
0.019805535674095154,
-0.015868794173002243,
0.010361405089497566,
0.009656965732574463,
0.0002613179385662079,
0.006015014834702015,
0.009140616282820702,
0.01127555686980486,
0.024625957012176514,
0.013968393206596375,
-0.004085325635969639,
0.05788950249552727,
-0.03508652001619339,
0.02208869904279709,
-0.006063270382583141,
0.012864572927355766,
0.0009566398803144693,
-0.0319904200732708,
-0.024890555068850517,
-0.003434264101088047,
0.024383360520005226,
-0.005859603174030781,
0.0352138951420784,
0.026068711653351784,
-0.00004123104736208916,
0.011224649846553802,
0.02421623468399048,
-0.012586602009832859,
-0.0028615142218768597,
-0.039735957980155945,
-0.00950911920517683,
0.034120310097932816,
-0.00965769775211811,
-0.0012198537588119507,
0.024042654782533646,
0.0073551577515900135,
-0.01703626662492752,
-0.011391693726181984,
0.011535828933119774,
0.010069502517580986,
0.013608582317829132,
-0.014767280779778957,
-0.007523713167756796,
0.0024520684964954853,
0.010528525337576866,
-0.005853406153619289,
0.010986417531967163,
-0.0019308673217892647,
0.0013715544482693076,
0.017004910856485367,
-0.03133636340498924,
0.02058190293610096,
0.009065483696758747,
0.0013406833168119192,
-0.02463485486805439,
-0.013995605520904064,
-0.025127001106739044,
-0.013375762850046158,
0.0007152222096920013,
0.0013126996345818043,
0.009984612464904785,
0.03733626753091812,
-0.0011473903432488441,
0.013783273287117481,
-0.0052631692960858345,
-0.009188690222799778,
0.006784931756556034,
-0.00488742021843791,
0.007490391843020916,
-0.0018535228446125984,
0.0019627113360911608,
-0.0025589382275938988,
0.00019554980099201202,
0.030413877218961716,
0.0091116176918149,
0.0013921144418418407,
0.06655046343803406,
-0.015238380990922451,
0.002139533869922161,
0.008313694968819618,
-0.021208738908171654,
-0.012728874571621418,
-0.0063584940508008,
-0.003973154816776514,
-0.011545245535671711,
-0.010289786383509636,
-0.02204948663711548,
-0.0007697232649661601,
-0.009946955367922783,
-0.008145999163389206,
-0.007860016077756882,
-0.0006513558328151703,
0.005289046093821526,
-0.02899779938161373,
0.024450210854411125,
-0.0008710019756108522,
0.002011606004089117,
-0.005078088492155075,
0.004418156109750271,
0.004705667030066252,
-0.04145383834838867,
-0.0008148015476763248,
0.03338385373353958,
0.004209338687360287,
-0.011416973546147346,
0.01684379391372204,
-0.018236905336380005,
0.030506040900945663,
-0.01406409963965416,
0.013359081000089645,
-0.0160483717918396,
0.024774447083473206,
0.011466402560472488,
-0.04183666408061981,
-0.004151318222284317,
-0.03267211839556694,
-0.01524793915450573,
-0.0009392122738063335,
0.004219477996230125,
0.009065534919500351,
0.006253498140722513,
0.006001213099807501,
0.011179586872458458,
0.008127374574542046,
0.010645529255270958,
0.022771045565605164,
-0.0024321763776242733,
0.012475555762648582,
-0.002995092887431383,
-0.004642535001039505,
-0.025213323533535004,
0.03278377652168274,
0.029474681243300438,
0.011484687216579914,
-0.042292237281799316,
-0.0016343030147254467,
-0.012454625219106674,
0.013048240914940834,
-0.025181684643030167,
0.027079537510871887,
-0.007917296141386032,
-0.01936376839876175,
-0.009699730202555656,
0.008138537406921387,
-0.017588913440704346,
0.026073291897773743,
-0.0069108582101762295,
0.006986294407397509,
0.0003679406363517046,
-0.005871156230568886,
0.02211674302816391,
0.0441061370074749,
-0.02007724530994892,
-0.028643455356359482,
-0.008149512112140656,
0.024970972910523415,
0.020157191902399063,
0.016009727492928505,
0.004031624179333448,
-0.012403680942952633,
0.0005249641835689545,
0.004553539212793112,
-0.007221568841487169,
0.026180772110819817,
-0.00834672898054123,
0.03954703360795975,
0.013345102779567242,
0.011433200910687447,
-0.0036824538838118315,
-0.006754232104867697,
-0.08160959929227829,
-0.004392141476273537,
-0.0069907428696751595,
0.030136562883853912,
0.006332110147923231,
-0.006174133624881506,
0.04173017293214798,
0.015971504151821136,
0.00775268767029047,
0.017048267647624016,
-0.0223358403891325,
0.014054231345653534,
-0.017348172143101692,
0.01968376711010933,
0.012860126793384552,
0.0015441857976838946,
-0.005141849629580975,
0.00011009816080331802,
-0.010138419456779957,
0.008250794373452663,
-0.003542826510965824,
0.04670039564371109,
0.02108832262456417,
-0.011520041152834892,
0.004161269869655371,
0.00921744853258133,
-0.009225718677043915,
-0.012865062803030014,
0.00665499921888113,
-0.0012341683031991124,
0.015932660549879074,
-0.01022428460419178,
-0.006229940801858902,
-0.019661881029605865,
-0.0051678759045898914,
-0.008581962436437607,
-0.007981227710843086,
0.010953598655760288,
-0.02470923587679863,
0.021642960608005524,
0.002064161002635956,
0.009486502036452293,
0.0038430867716670036,
-0.0201494749635458,
0.003183875698596239,
0.018046220764517784,
-0.007771388161927462,
0.011299261823296547,
0.009371551685035229,
-0.005154972430318594,
0.014699374325573444,
-0.006350034847855568,
0.017364127561450005,
-0.008263571187853813,
-0.022032197564840317,
-0.021502899006009102,
0.006085940636694431,
-0.006760658696293831,
-0.015262647531926632,
-0.011023652739822865,
-0.0034020417369902134,
-0.023780900985002518,
0.008767721243202686,
-0.004787943325936794,
0.021106982603669167,
-0.014072936028242111,
0.004588367883116007,
-0.012018815614283085,
-0.018168549984693527,
-0.0011676609283313155,
0.00595506839454174,
-0.011835087090730667,
-0.04144476354122162,
-0.010208716616034508,
0.0234824325889349,
-0.001831171102821827,
-0.013661233708262444,
0.005325207486748695,
0.043766170740127563,
0.024991650134325027,
0.0007721427828073502,
-0.016383787617087364,
0.0013647577725350857,
-0.007783927954733372,
-0.03224007785320282,
0.024388058111071587,
0.01468956470489502,
-0.005070557817816734,
0.01700439304113388,
-0.011356601491570473,
-0.025919344276189804,
0.017387427389621735,
-0.026294665411114693,
0.004219480790197849,
0.0018709194846451283,
-0.0025108507834374905,
0.007077426183968782,
0.0023283646441996098,
0.013227157294750214,
0.010316886007785797,
0.0062096007168293,
0.003005231497809291,
-0.02072051726281643,
-0.01302698440849781,
-0.01173160970211029,
0.009535814635455608,
0.03314322978258133,
-0.05212463065981865,
-0.014237208291888237,
-0.02342810481786728,
-0.03696766495704651,
-0.0194423645734787,
-0.00955617893487215,
0.05121758580207825,
0.0023398236371576786,
0.02413991466164589,
0.010779926553368568,
-0.006545409094542265,
0.07229025661945343,
0.00805865228176117,
0.01302728895097971,
-0.014286834746599197,
-0.003122903173789382,
0.010675787925720215,
-0.03640301525592804,
0.002009187825024128,
-0.00044835498556494713,
-0.02661236934363842,
0.013114122673869133,
0.03080862946808338,
0.015945501625537872,
-0.03655880689620972,
0.01942678913474083,
0.012077324092388153,
-0.01952119544148445,
0.025403223931789398,
0.0008875664789229631,
-0.01200588047504425,
-0.022654609754681587,
0.026849625632166862,
0.036598674952983856,
-0.0005632288521155715,
-0.017303675413131714,
-0.0003981349873356521,
0.01016905065625906,
-0.013700274750590324,
0.01234688051044941,
0.001936962828040123,
-0.012035216204822063,
-0.009190794080495834,
-0.0021501295268535614,
-0.017086822539567947,
0.012806493788957596,
-0.005724272690713406,
-0.03113638609647751,
-0.00004836078733205795,
0.01271071471273899,
0.002911178395152092,
-0.00853439699858427,
-0.005051124840974808,
-0.011696410365402699,
0.028303993865847588,
-0.011344400234520435,
-0.006293403450399637,
0.012888593599200249,
-0.007790570612996817,
-0.008127395063638687,
0.009372953325510025,
-0.019046174362301826,
0.02889113686978817,
0.01626667194068432,
0.003052821382880211,
0.001190901268273592,
-0.004990978632122278,
-0.01941397786140442,
-0.017672695219516754,
-0.011118589900434017,
-0.013684170320630074,
-0.00030590989626944065,
0.01061742752790451,
0.013756667263805866,
-0.01603962667286396,
-0.016577987000346184,
-0.005095192231237888,
0.009375542402267456,
-0.011408592574298382,
0.03974597901105881,
-0.012161306105554104,
-0.019897833466529846,
-0.025824761018157005,
0.006940359249711037,
-0.004050374962389469,
0.0032286150380969048,
0.011772303842008114,
-0.008999625220894814,
-0.0014357734471559525,
0.013204731047153473,
-0.028864867985248566,
0.014073796570301056,
0.006874697748571634,
0.004426485858857632,
-0.0269160233438015,
-0.008113464340567589,
0.004986467305570841,
-0.04096650704741478,
-0.0746002197265625,
-0.0319749116897583,
-0.0003879871219396591,
-0.016371633857488632,
-0.0030218372121453285,
0.004764510318636894,
-0.005810994654893875,
-0.015582431107759476,
0.0003209363203495741,
-0.017082946375012398,
-0.06358630955219269,
0.019900579005479813,
0.02007901296019554,
-0.019650455564260483,
0.014622409828007221,
0.008504962548613548,
0.014758274890482426,
-0.025418387725949287,
-0.02097270078957081,
-0.026028109714388847,
-0.0059827519580721855,
0.020844608545303345,
-0.02237270399928093,
0.016650177538394928,
0.016491398215293884,
-0.08110405504703522,
0.018818294629454613,
0.0028276280499994755,
-0.02597085013985634,
0.007886471226811409,
-0.012983432039618492,
-0.004660716280341148,
-0.005046989768743515,
-0.0234757661819458,
-0.015338242053985596,
-0.005426665302366018,
-0.007473374716937542,
0.031229881569743156,
-0.0004679691046476364,
-0.014603463001549244,
-0.010039672255516052,
0.024023640900850296,
-0.00886755995452404,
0.0056313988752663136,
-0.004950000438839197,
-0.006557215005159378,
0.011441497132182121,
-0.00771595723927021,
0.009502874687314034,
-0.001503560459241271,
-0.020860664546489716,
-0.012534568086266518,
0.011328250169754028,
0.020750559866428375,
-0.028199655935168266,
0.007774814963340759,
-0.0009021083824336529,
-0.03867289423942566,
-0.003249687608331442,
-0.005837718024849892,
-0.0169623214751482,
-0.010949012823402882,
-0.030298668891191483,
-0.030873488634824753,
-0.0019536977633833885,
-0.003417961299419403,
-0.0007409551180899143,
0.013050691224634647,
0.008266245946288109,
-0.002378994133323431,
-0.0024807793088257313,
0.007490961812436581,
0.0053352415561676025,
0.013450469821691513,
0.012348231859505177,
0.018529314547777176,
0.015054942108690739,
-0.0051017627120018005,
-0.012851694598793983,
-0.02501259744167328,
0.025703536346554756,
0.008732246235013008,
0.01928475871682167,
-0.022093717008829117,
0.010493848472833633,
-0.015395669266581535,
-0.02806999906897545,
-0.007523972541093826,
0.07123003154993057,
-0.02831193059682846,
0.011009447276592255,
-0.015549717471003532,
-0.01027505099773407,
-0.0033388687297701836,
-0.030318770557641983,
-0.020078003406524658,
-0.0008547268807888031,
-0.0020852498710155487,
0.012608235701918602,
-0.0066839237697422504,
0.01596834696829319,
0.007968088611960411,
0.012537076137959957,
-0.003111517522484064,
-0.01575596258044243,
-0.00038823741488158703,
0.0013117050984874368,
-0.008810301311314106,
-0.026954399421811104,
-0.008548516780138016,
-0.010270163416862488,
0.0060031539760529995,
0.01167881116271019,
-0.006637031212449074,
-0.004615186247974634,
0.00695045106112957,
0.004572543781250715,
0.009005161002278328,
-0.031472884118556976,
-0.004805967211723328,
0.00855640321969986,
0.016627013683319092,
0.013177570886909962,
0.012971284799277782,
-0.017809124663472176,
0.0025834916159510612,
0.012922144494950771,
-0.024190589785575867,
0.005143069662153721,
-0.0102997412905097,
0.01664735935628414,
-0.031016767024993896,
0.022845881059765816,
-0.0076190391555428505,
0.004257343243807554,
-0.027689147740602493,
-0.04161219298839569,
0.03237677365541458,
0.017067380249500275,
0.002102989237755537,
-0.020599033683538437,
-0.035049919039011,
-0.012589022517204285,
-0.027626991271972656,
0.014074200764298439,
0.021074438467621803,
0.009021277539432049,
-0.038819726556539536,
-0.002598630031570792,
-0.007969686761498451,
-0.005946137011051178,
-0.0023392087314277887,
-0.01641019433736801,
0.005026106722652912,
0.018003389239311218,
-0.012749322690069675,
0.0006664185784757137,
0.013053969480097294,
0.0034512747079133987,
0.020138822495937347,
0.008907122537493706,
0.01960095390677452,
0.002688452135771513,
0.0031134793534874916,
-0.013374252244830132,
0.017522573471069336,
0.0016646417789161205,
0.01879218965768814,
-0.0313645638525486,
0.019238388165831566,
-0.022362399846315384,
0.012499859556555748,
-0.007888518273830414,
0.015118220821022987,
0.040747713297605515,
0.0021792100742459297,
-0.012208806350827217,
0.005914532579481602,
0.04870886728167534,
-0.015856560319662094,
-0.0003817550605162978,
0.0355139896273613,
0.00411104504019022,
0.03510470688343048,
-0.03177183121442795,
0.007982714101672173,
0.031864069402217865,
0.006602794863283634,
-0.012353644706308842,
-0.0013883400242775679,
-0.0035201534628868103,
-0.009296325966715813,
-0.02645406499505043,
0.005766504909843206,
0.02066207304596901,
0.012888796627521515,
0.03700559586286545,
-0.014143146574497223,
0.0007817198056727648,
-0.0074479589238762856,
0.03180022910237312,
0.0016801732126623392,
0.017143666744232178,
0.01809481531381607,
0.0032385471276938915,
-0.007799748331308365,
0.0217721126973629,
-0.011926346458494663,
-0.02440715953707695,
-0.0005260617472231388,
-0.01261573564261198,
0.012120083905756474,
-0.035873234272003174,
-0.006406054366379976,
-0.005737002938985825,
-0.0030681390780955553,
-0.010821669362485409,
-0.008828641846776009,
-0.004833846352994442,
0.022011883556842804,
0.02083343267440796,
0.02631325274705887,
-0.011416342109441757,
0.00019636563956737518,
-0.0001225941814482212,
0.015820613130927086,
-0.022659244015812874,
-0.020980069413781166,
-0.0018663802184164524,
-0.005303654354065657,
0.009912951849400997,
0.009038032032549381,
0.008183324709534645,
-0.011718206107616425,
0.00003264704719185829,
0.024164292961359024,
0.013952929526567459,
-0.014244481921195984,
0.01965850405395031,
-0.014680955559015274,
0.01125116366893053,
-0.003058257047086954,
-0.006918308325111866,
0.009171645157039165,
-0.005582669749855995,
0.007742925547063351,
0.008744260296225548,
-0.007234120275825262,
-0.0006776158697903156,
-0.03300928324460983,
-0.018247904255986214,
0.004341441206634045,
-0.0007686631288379431,
-0.030455749481916428,
-0.014356927014887333,
0.014471985399723053,
-0.0063842181116342545,
0.0038810824044048786,
0.019405744969844818,
-0.020379021763801575,
0.0007863987702876329,
0.020222865045070648,
-0.011415395885705948,
-0.009785876609385014,
0.01024908572435379,
0.012239007279276848,
0.029650185257196426,
0.0015272917225956917,
0.012373991310596466,
0.0031132721342146397,
-0.00025613466277718544,
-0.01357840932905674,
-0.01777428388595581,
0.0040190210565924644,
0.0025687217712402344,
-0.003988277167081833,
-0.004489094018936157,
-0.01007876731455326,
-0.01151188649237156,
-0.015569809824228287,
-0.03209588676691055,
-0.017144033685326576,
0.0032717916183173656,
0.011035056784749031,
0.010854407213628292,
-0.010821851901710033,
-0.004898891784250736,
-0.002191644161939621,
-0.0141095956787467,
-0.016879232600331306
] | [
0.06884442269802094,
0.31612759828567505,
0.5359461903572083,
-0.03022216446697712,
0.20036913454532623,
0.7790100574493408,
0.17634163796901703,
-0.6130191683769226,
0.216419979929924,
-0.1955636590719223,
0.1484588235616684,
0.6876730918884277,
-0.15456362068653107,
-0.1293075680732727,
-0.22518563270568848,
0.8558403253555298,
0.4095616936683655,
0.1989494115114212,
-0.332738995552063,
-0.5237913727760315,
-0.11519361287355423,
-0.3272258937358856,
0.3819543421268463,
-0.15494053065776825,
-0.37354767322540283,
0.39251333475112915,
0.3481326997280121,
0.1881672441959381,
0.15135909616947174,
-0.04476867616176605,
0.054948728531599045,
0.40892818570137024,
0.4483417868614197,
-0.29244178533554077,
0.0380198135972023,
-0.015481480397284031,
0.2245788723230362,
0.36373522877693176,
-0.08270297199487686,
-0.391757607460022,
-0.26924315094947815,
-0.2612208425998688,
-0.4129616320133209,
0.7731829285621643,
-0.12935391068458557,
-0.29804956912994385,
-1.3816276788711548,
0.41985198855400085,
-0.49111518263816833,
0.3071959316730499,
0.05670548602938652,
0.2321019321680069,
1.0651963949203491,
0.27718573808670044,
-0.16032761335372925,
0.10201399773359299,
-0.12080681324005127,
-0.1025625541806221,
0.04306485503911972,
-0.5469052791595459,
0.33837124705314636,
0.21855559945106506,
0.5594620704650879,
0.40868568420410156,
-0.20595873892307281,
0.6488520503044128,
0.042100321501493454,
-0.15158402919769287,
-0.09926596283912659,
0.17571401596069336,
-0.032614629715681076,
-0.15152336657047272,
-0.27986493706703186,
0.2399834245443344,
-0.0940278172492981,
0.11937674880027771,
-0.08770740777254105,
-0.6512693166732788,
0.4295220673084259,
-0.30760544538497925,
-0.2695055305957794,
-0.17499881982803345,
0.2859896421432495,
-0.17603884637355804,
0.32708147168159485,
-0.2446565479040146,
0.1616118848323822,
0.28560417890548706,
0.07175571471452713,
0.08372513949871063,
-0.28008171916007996,
-0.3545510172843933,
0.38103440403938293,
0.35862451791763306,
-0.06646836549043655,
0.2060285359621048,
0.46101367473602295,
-0.4190419912338257,
-0.002468558494001627,
0.0651802346110344,
0.10258837044239044,
0.539752721786499,
0.09954178333282471,
-0.2759395241737366,
-0.5893639922142029,
-0.3082902431488037,
0.02317759022116661,
-0.828135073184967,
-0.4479060471057892,
0.3525719940662384,
-0.8479840159416199,
-0.16037075221538544,
-0.2401401847600937,
-0.14326807856559753,
-0.3500189483165741,
0.2350865602493286,
0.0030884365551173687,
-0.5867899656295776,
-0.29822903871536255,
-0.1537511646747589,
-0.5126102566719055,
0.5751485824584961,
-0.18806840479373932,
-0.23112410306930542,
0.1566876620054245,
-0.07214290648698807,
0.6249497532844543,
-0.18839894235134125,
-0.4929860532283783,
0.6207355260848999,
0.1449093371629715,
0.293189138174057,
-0.2149117887020111,
0.09341036528348923,
-0.3431684672832489,
-0.5887178182601929,
0.24096857011318207,
0.6323603987693787,
-0.07348071038722992,
0.3430139422416687,
-0.28902703523635864,
-0.5877376794815063,
-0.15618379414081573,
-0.03209832310676575,
0.569190502166748,
-0.4900085926055908,
0.14460894465446472,
-0.2726837396621704,
-0.6431503891944885,
-0.15078631043434143,
-0.7167052626609802,
0.03768684342503548,
0.47702351212501526,
-0.6434063911437988,
0.5821254849433899,
0.5828007459640503,
-0.026493491604924202,
-0.25388720631599426,
0.4727575480937958,
-0.5210996270179749,
0.1405583620071411,
0.16287048161029816,
-0.7719064950942993,
0.12592583894729614,
0.38363343477249146,
0.1267038732767105,
0.07478485256433487,
0.4615670442581177,
-0.017728684470057487,
0.4784604609012604,
-0.22729118168354034,
-0.06984125822782516,
-0.41530290246009827,
-0.46511849761009216,
-0.45336174964904785,
0.5771014094352722,
0.542351245880127,
0.37531834840774536,
0.2877355217933655,
-0.40207889676094055,
-0.6260559558868408,
-0.29299497604370117,
-0.2596108615398407,
-0.5999902486801147,
0.4139460623264313,
-0.4110531806945801,
-0.05162372812628746,
0.28638479113578796,
-0.2061111181974411,
0.0633077621459961,
-0.5026499032974243,
-0.5105408430099487,
0.35898566246032715,
-0.3353872299194336,
1.0533782243728638,
-0.5186008810997009,
0.041360266506671906,
0.9306349754333496,
0.5910490155220032,
-0.6044711470603943,
-0.1469639241695404,
0.2817356586456299,
-0.01731862686574459,
0.2555878162384033,
-0.500373125076294,
0.19557061791419983,
-0.09620152413845062,
-0.47294074296951294,
-0.2878491282463074,
0.3100588917732239,
0.21814817190170288,
-0.3880656361579895,
-0.4804143011569977,
-0.20844392478466034,
-0.24020983278751373,
-0.029779737815260887,
0.036542899906635284,
0.6010416746139526,
0.2528851330280304,
-0.08070375770330429,
0.8471070528030396,
-0.3165125846862793,
0.3509647250175476,
0.427430123090744,
0.4679274260997772,
0.6954780220985413,
0.2482818067073822,
0.5733435153961182,
0.01512991078197956,
-0.23080791532993317,
0.42080244421958923,
-0.2718394994735718,
0.38127249479293823,
-0.5440923571586609,
-0.30360743403434753,
0.23379242420196533,
-0.23042777180671692,
-0.22504806518554688,
0.04489307478070259,
-0.6430420279502869,
-0.1504300832748413,
-0.0955023467540741,
-0.19334547221660614,
0.167079359292984,
0.12503860890865326,
-0.2986481189727783,
-0.9005275964736938,
0.09752374142408371,
-0.35608962178230286,
0.43630892038345337,
-0.34104225039482117,
0.1269630342721939,
-0.035820141434669495,
-0.013859459199011326,
0.6157096028327942,
-0.07285657525062561,
0.02055843360722065,
-0.2697180509567261,
0.069329172372818,
-0.2902621030807495,
-0.026423100382089615,
0.35592231154441833,
0.3288656771183014,
0.45223575830459595,
-0.2645546495914459,
-0.5860651731491089,
-0.41468480229377747,
-0.640823245048523,
0.6040986180305481,
0.6843112111091614,
0.38179054856300354,
0.5093157887458801,
-0.8968532681465149,
0.25727835297584534,
-0.3360019326210022,
-0.3840937316417694,
0.15630684792995453,
0.3743687570095062,
-0.12696802616119385,
-0.2808888256549835,
0.336368590593338,
0.08523212373256683,
0.8221769332885742,
-0.2726791501045227,
0.3815613389015198,
-0.3113813102245331,
-0.2981410026550293,
0.14776408672332764,
-0.39242690801620483,
-0.0629783421754837,
-0.2690252363681793,
0.8125200867652893,
0.03886444866657257,
-0.38838592171669006,
0.14814814925193787,
0.33749130368232727,
0.003516195574775338,
0.46499186754226685,
0.5967375636100769,
0.38187962770462036,
-0.3180449903011322,
0.3813132047653198,
0.08615394681692123,
-0.14946331083774567,
-0.10951773822307587,
-0.6994796395301819,
-0.10831329226493835,
0.2947366535663605,
-5.996274948120117,
0.28960901498794556,
-0.7223145961761475,
-0.2799474596977234,
0.20611435174942017,
0.05067281424999237,
0.9458040595054626,
-0.6099573969841003,
0.16962206363677979,
0.35590922832489014,
0.06572466343641281,
0.5362256169319153,
0.4569171667098999,
0.04999735951423645,
0.2921203076839447,
0.8916963934898376,
0.03030460514128208,
-0.22843068838119507,
0.42764711380004883,
-0.24492144584655762,
0.7900305986404419,
-0.20927205681800842,
-0.014362833462655544,
0.4868236482143402,
0.19239743053913116,
0.7251782417297363,
-0.5988211631774902,
-0.04891775920987129,
0.10049562156200409,
0.012985536828637123,
-0.044084880501031876,
-0.027225064113736153,
-0.3961121737957001,
0.1427040696144104,
0.6041922569274902,
0.13339994847774506,
0.20594967901706696,
0.021201269701123238,
-0.004270294681191444,
-0.4159913659095764,
0.07379770278930664,
0.6790458559989929,
-0.1066516861319542,
-0.14379027485847473,
0.527990996837616,
0.38895487785339355,
-0.2539263367652893,
0.22997277975082397,
0.013609452173113823,
0.385587215423584,
0.1736724078655243,
0.09813041239976883,
0.4050646126270294,
0.7971512675285339,
0.16139566898345947,
-0.13011586666107178,
0.09945861250162125,
0.16538962721824646,
-0.33023467659950256,
-0.16220593452453613,
-0.5637907385826111,
-0.2690177857875824,
-0.22663559019565582,
-0.7811858654022217,
0.027652915567159653,
0.3198314309120178,
-0.5882008075714111,
-0.4475201964378357,
-0.08241547644138336,
-0.18476763367652893,
-0.8091941475868225,
0.2566024959087372,
-0.060556065291166306,
-0.81158047914505,
0.43347853422164917,
-0.23263147473335266,
0.1748965084552765,
0.39171332120895386,
0.16983461380004883,
-0.35354310274124146,
-0.2236054390668869,
0.04779457673430443,
-0.0862729623913765,
-0.33906060457229614,
0.43928372859954834,
-0.6181850433349609,
0.06739643961191177,
-0.24248139560222626,
-0.20353297889232635,
0.15139009058475494,
-0.07290274649858475,
-0.11056151241064072,
0.3687116205692291,
0.5004649758338928,
0.7334665060043335,
0.5526581406593323,
-0.09011378139257431,
0.6050283908843994,
0.6110178232192993,
-0.22104501724243164,
0.8504028916358948,
-0.008812169544398785,
-0.21614350378513336,
-1.0554660558700562,
-0.21162894368171692,
0.044560134410858154,
-1.0043511390686035,
-0.2341947853565216,
0.4850071370601654,
-0.4896889328956604,
0.03773263841867447,
0.30925828218460083,
-0.06768318265676498,
-0.19312319159507751,
0.7564441561698914,
-0.14340147376060486,
-0.24877770245075226,
0.31869715452194214,
0.5863249897956848,
0.2122262716293335,
-0.08706732839345932,
0.1268303245306015,
0.16783344745635986,
0.2588653862476349,
-0.23160628974437714,
-0.23782311379909515,
0.2799019515514374,
0.022162463515996933,
-0.6674299240112305,
0.7096547484397888,
0.36074328422546387,
0.2969346344470978,
-0.4126681685447693,
0.18193402886390686,
0.3384808301925659,
-0.19850613176822662,
-0.6958688497543335,
0.14079025387763977,
-0.20292377471923828,
0.023268375545740128,
-0.2566791772842407,
0.17685328423976898,
-0.28580692410469055,
0.30165040493011475,
-0.43907979130744934,
-0.2224065065383911,
0.08724090456962585,
0.24040943384170532,
-0.011108475737273693,
0.2933342456817627,
-0.06935766339302063,
0.04968782141804695,
0.28574350476264954,
-0.043421756476163864,
0.08674457669258118,
0.24284496903419495,
-0.024557694792747498,
0.2638588547706604,
0.002948123961687088,
-0.2842552363872528,
-0.28817418217658997,
0.17017947137355804,
-1.262856364250183,
-0.23061923682689667,
0.000051015234930673614,
-0.5280472040176392,
-0.7083740830421448,
-0.13370729982852936,
-0.18910567462444305,
0.20030394196510315,
0.04271838068962097,
-0.32013630867004395,
-0.5174332857131958,
-0.029011737555265427,
0.29531118273735046,
0.08344244211912155,
-0.30385544896125793,
0.40677469968795776,
-0.08477986603975296,
0.5155932307243347,
0.15985380113124847,
-0.4148268401622772,
-0.28194233775138855,
-0.04377233237028122,
0.9196200966835022,
0.2604295313358307,
-0.10601305961608887,
-0.42816662788391113,
-0.07789215445518494,
0.035403985530138016,
0.0867491364479065,
0.17845523357391357,
0.2619984447956085,
-0.4245966374874115,
0.10856211930513382,
-0.24816875159740448,
0.42018750309944153,
0.2873951196670532,
-0.2037615329027176,
0.00993439182639122,
-0.05360528454184532,
0.2785150408744812,
-1.028221607208252,
0.27540677785873413,
0.3639369606971741,
-0.45757871866226196,
0.11345814168453217,
-0.5482968091964722,
-0.3428207039833069,
-0.12499433755874634,
-0.7636561393737793,
0.1997286081314087,
-0.2266189455986023,
0.15741541981697083,
-0.5811614990234375,
0.4329873025417328,
-0.1868717223405838,
-0.6110966205596924,
-0.28032466769218445,
0.03962824121117592,
-0.11449916660785675,
-0.39093017578125,
-0.35967519879341125,
-0.05745178088545799,
-0.27146777510643005,
-0.25051218271255493,
0.4415011405944824,
-0.5471897721290588,
-0.14916551113128662,
-0.10376117378473282,
-0.3654777705669403,
-0.12368175387382507,
0.05761737376451492,
0.09419862926006317,
-0.2684308886528015,
-0.2847825884819031,
-0.3137110471725464,
-0.22145718336105347,
0.3439970016479492,
0.3380008041858673,
0.10187327861785889,
0.7956504821777344,
-0.13157042860984802,
-0.03991683945059776,
0.12306172400712967,
0.04746691882610321,
0.4454585313796997,
-0.9215157628059387,
-0.20801924169063568,
-0.09488477557897568,
0.7418110370635986,
-0.3362311124801636,
0.001372696366161108,
-0.13826890289783478,
0.23709966242313385,
-0.0259153563529253,
-0.36112868785858154,
-0.2853121757507324,
0.2021058201789856,
-0.02004072815179825,
0.06729914247989655,
-0.14614838361740112,
-0.5335466861724854,
-0.23642899096012115,
0.058616191148757935,
0.1423567682504654,
0.2535181939601898,
-0.3928619921207428,
-0.11508440226316452,
-0.3887072801589966,
0.33956727385520935,
-0.09259247779846191,
0.039300233125686646,
0.30826646089553833,
-0.06165840104222298,
0.13935616612434387,
-0.10921061038970947,
0.07520939409732819,
0.2573579251766205,
-0.037650011479854584,
-0.37359052896499634,
-0.30030545592308044,
-0.23198777437210083,
0.13962823152542114,
0.1808527261018753,
-0.5339800715446472,
0.02293943613767624,
-0.34461429715156555,
-0.40951451659202576,
-0.2830635607242584,
0.2565062642097473,
0.09812470525503159,
-0.6207751631736755,
0.22446990013122559,
0.4856704771518707,
0.10643626004457474,
0.6640902757644653,
0.2823181450366974,
-0.4715414047241211,
-0.10727261006832123,
-0.32241228222846985,
0.5460093021392822,
0.7478322386741638,
-0.5416303277015686,
0.39282724261283875,
0.12374526262283325,
0.2901175022125244,
-0.6259360909461975,
-0.0965275689959526,
-0.17523658275604248,
0.39334920048713684,
-0.033206742256879807,
0.3136696219444275,
0.47838184237480164,
-0.6927286982536316,
-0.7881543636322021,
-0.3635201156139374,
-0.13947194814682007,
0.3500498831272125,
0.1748581826686859,
0.0699867233633995,
0.44508078694343567,
0.8074859976768494,
0.04665089398622513,
0.22718223929405212,
0.3988107442855835,
0.10963044315576553,
-0.0017371579306200147,
-0.11172531545162201,
0.6766688823699951,
0.6022617816925049,
0.883358895778656,
0.16014564037322998,
-0.09124492108821869,
0.10152050852775574,
-0.0048564039170742035,
-0.22612306475639343,
-0.06887531280517578,
-0.5453166961669922,
0.34253203868865967,
0.21462483704090118,
0.17239727079868317,
0.09497756510972977,
-0.10403366386890411,
0.20806670188903809,
0.6085803508758545,
0.3605369031429291,
0.29768893122673035,
0.1552647054195404,
-0.08722512423992157,
-0.032521966844797134,
0.16637299954891205,
-0.023086560890078545,
0.04997647553682327,
-0.4007967710494995,
0.4533292353153229,
0.0061578149907290936,
-0.24191711843013763,
-0.5549212098121643,
0.42803874611854553,
-0.03537440299987793,
-0.2146039605140686,
-0.2044317126274109,
0.1408585011959076,
-0.0908527746796608,
-0.1486404687166214,
0.11863141506910324,
0.14869141578674316,
0.24310597777366638,
0.23830842971801758,
0.2342728078365326,
0.40316712856292725,
-0.734318733215332,
0.04940293729305267,
-0.49494391679763794,
-0.6414650678634644,
0.4806075990200043,
-0.39925915002822876,
0.164651557803154,
0.40617358684539795,
-0.25992217659950256,
-0.07929734140634537,
0.11420261859893799,
-0.5864577293395996,
-0.21758529543876648,
0.1965116560459137,
-0.13600459694862366,
0.22793960571289062,
0.28835076093673706,
-0.03471377119421959,
0.45576679706573486,
-0.6607612371444702,
-0.375070184469223,
0.06190747395157814,
-0.2943915128707886,
0.06262990087270737,
-0.0043676369823515415,
-0.06547147035598755,
0.6265865564346313,
0.3404623568058014,
-0.3645276725292206,
0.1942773014307022,
0.12396197766065598,
0.38218042254447937,
-0.18439465761184692,
0.3055945038795471,
-0.6843494176864624,
-0.6113676428794861,
-0.7278265357017517,
-0.17176875472068787,
0.22983500361442566,
0.031989049166440964,
-0.09835710376501083,
0.17791718244552612,
0.08765880763530731,
0.4833366870880127,
0.3244152069091797,
-0.4454982876777649,
0.12959377467632294,
-0.3224543631076813,
-0.27979418635368347,
-0.46276170015335083,
0.7084189057350159,
0.09789951145648956,
-0.4247951805591583,
-0.024876192212104797,
0.2690615952014923,
0.16417673230171204,
-0.11647161841392517,
0.8178108334541321,
-0.13443595170974731,
-0.11845014989376068,
-0.1880587637424469,
-0.1783592700958252,
-0.4887502193450928,
-0.06112654134631157,
-0.06375138461589813,
0.4474354386329651,
0.25446638464927673,
-0.2639133036136627,
0.005806594155728817,
-0.7650481462478638,
-0.09960872679948807,
0.3425480127334595,
0.021645493805408478,
0.5641694068908691,
0.2878795564174652,
-0.15255871415138245,
-0.6439124941825867,
0.1390717327594757,
-0.3922928273677826,
-0.6570227742195129,
0.19012831151485443,
-0.626700222492218,
-0.13084712624549866,
-0.040388621389865875,
-0.2336282730102539,
-0.37791889905929565,
0.16564379632472992,
0.29796168208122253
] |
There has never been a book on headache that came close to that of the late Harold Wolff. The second edition was published 10 years ago; it was and is a masterpiece of writing, an exhaustive yet engrossing delineation of Wolff's long study and understanding of headache. The new edition, revised by Dalessio, serves to bring certain aspects of headache up to date, most of them having to do with drug therapy. The emphasis on total therapy rather than simply drug therapy has been preserved, however. Dalessio has altered slightly the form of the book, although the "new chapters" on cluster headache and trigeminal neuralgia are merely transplants from other sections of the original. Migraine, the main part of the book, has been reshaped, with some anecdotal portions removed, but little has been added. It is of interest that nothing in the section on observations of methysergide (UML-491 in Wolff's | [
-0.008581705391407013,
-0.0008320542983710766,
-0.029799478128552437,
0.008990749716758728,
-0.008216910995543003,
0.00696802232414484,
0.008134373463690281,
0.02184002846479416,
-0.015482857823371887,
0.02112085558474064,
-0.010422037914395332,
0.01112288050353527,
-0.004905465990304947,
-0.015123704448342323,
0.021732065826654434,
0.01893094927072525,
-0.03923013061285019,
0.0007837241282686591,
0.015444278717041016,
-0.014988530427217484,
-0.004671555012464523,
0.008527363650500774,
0.0077879284508526325,
0.01737973466515541,
-0.036528125405311584,
-0.006576097570359707,
-0.022690780460834503,
-0.013066817075014114,
0.01857033558189869,
0.02216779813170433,
-0.0022970042191445827,
-0.00035500433295965195,
-0.0025273326318711042,
0.005067015998065472,
0.00884416326880455,
0.034019630402326584,
-0.009588879533112049,
0.019598007202148438,
-0.020677948370575905,
-0.003324363147839904,
-0.006423869635909796,
-0.0031770046334713697,
0.009168192744255066,
0.020150775089859962,
-0.009770527482032776,
-0.00037188571877777576,
-0.007553788833320141,
-0.024547016248106956,
-0.013291547074913979,
0.008045829832553864,
0.003511750139296055,
0.006080579943954945,
-0.00823955424129963,
0.01521544810384512,
-0.005110561847686768,
0.014635127037763596,
0.017795227468013763,
0.007061857730150223,
-0.01641276851296425,
0.016690567135810852,
0.0055512017570436,
0.03020487353205681,
-0.02667122334241867,
0.020235784351825714,
0.0021744135301560163,
-0.06722943484783173,
-0.01505540031939745,
-0.028359830379486084,
-0.0004809077945537865,
-0.0024169287644326687,
-0.008383707143366337,
0.019837861880660057,
-0.009586554020643234,
-0.00517307547852397,
-0.01819540746510029,
0.02862038090825081,
0.00826017651706934,
-0.018979951739311218,
0.008286690339446068,
0.011804264038801193,
0.0156458280980587,
-0.033058665692806244,
0.03170304372906685,
0.01067945547401905,
-0.0007020779885351658,
0.010087328031659126,
-0.0006393283838406205,
-0.00464897183701396,
0.021485667675733566,
-0.011354755610227585,
0.027559295296669006,
-0.03961767628788948,
-0.00820877030491829,
0.0029807202517986298,
-0.002684404607862234,
0.005574848037213087,
0.007496368605643511,
-0.014783833175897598,
-0.008346072398126125,
-0.026112832129001617,
0.013703329488635063,
0.02296755649149418,
0.01593291014432907,
-0.01588861644268036,
0.0023775582667440176,
0.00795610062777996,
0.006601565517485142,
0.004441022407263517,
-0.03213744983077049,
0.004385838285088539,
-0.00613735057413578,
0.007005974184721708,
0.004303550347685814,
0.005319673102349043,
0.017371416091918945,
-0.004205163102596998,
0.005062048323452473,
-0.005354415159672499,
0.011227549985051155,
0.01821359619498253,
0.009960772469639778,
-0.0014036493375897408,
0.020213738083839417,
0.004475315101444721,
-0.0030581143219023943,
-0.014834234490990639,
-0.0032229823991656303,
-0.0011025089770555496,
-0.017214100807905197,
-0.008408889174461365,
-0.008098213002085686,
0.005780378356575966,
0.016204433515667915,
-0.0023595686070621014,
-0.0015184426447376609,
-0.01587953045964241,
-0.03235574811697006,
0.008595538325607777,
0.007030283100903034,
0.007526512257754803,
0.018930179998278618,
0.006600485183298588,
0.0008064938010647893,
0.007706965319812298,
0.004452259745448828,
-0.01546558365225792,
0.024524807929992676,
0.006729720160365105,
-0.010408659465610981,
0.0020088893361389637,
0.010185717605054379,
0.0014785639941692352,
0.015292123891413212,
-0.001907426049001515,
-0.009245356544852257,
-0.0018189884722232819,
-0.007729196920990944,
-0.005369475111365318,
-0.026043115183711052,
-0.01535370759665966,
-0.020375974476337433,
0.008820002898573875,
-0.0007234239019453526,
0.007792691234499216,
0.005062694661319256,
0.01956813968718052,
-0.002307552145794034,
-0.008605990558862686,
-0.004287886433303356,
0.0025529437698423862,
-0.005172600969672203,
0.03782328963279724,
-0.006587363313883543,
0.012973200529813766,
-0.008229928091168404,
-0.02478431537747383,
0.03997185826301575,
0.004206676036119461,
-0.0014499824028462172,
0.06673018634319305,
-0.004532134626060724,
-0.006347143556922674,
-0.0188643429428339,
0.027290266007184982,
-0.006400344893336296,
-0.000058864476159214973,
0.020569689571857452,
0.0027080760337412357,
-0.010128464549779892,
-0.004832404665648937,
-0.00450633279979229,
0.02742183767259121,
-0.0037986612878739834,
-0.012520857155323029,
0.012044994160532951,
0.003013842971995473,
0.018426433205604553,
0.007349029183387756,
0.004693745169788599,
0.015946298837661743,
0.0006195348687469959,
-0.0023101894184947014,
0.02792179025709629,
-0.015161615796387196,
-0.028877247124910355,
0.016757216304540634,
0.025000032037496567,
-0.00494718924164772,
-0.007046131417155266,
-0.021442677825689316,
0.018001938238739967,
-0.009262983687222004,
-0.006425183266401291,
-0.002588054398074746,
-0.016021832823753357,
0.0069878497160971165,
-0.006247119978070259,
0.01024753786623478,
-0.017288779839873314,
-0.018709369003772736,
-0.006960227154195309,
-0.00064071174710989,
-0.0010109534487128258,
-0.025791794061660767,
0.007957762107253075,
0.0244875680655241,
-0.00036163697950541973,
0.013258992694318295,
-0.01140487752854824,
-0.006231794133782387,
-0.010068351402878761,
-0.01242818869650364,
-0.0073373205959796906,
0.0038113014306873083,
-0.005397090222686529,
-0.0017537816893309355,
0.007071068976074457,
-0.024103878065943718,
0.01039829570800066,
-0.010061109438538551,
-0.0049718087539076805,
-0.03381579369306564,
0.011612020432949066,
-0.002107917796820402,
-0.01072021760046482,
0.0007366116624325514,
-0.0010412330739200115,
-0.010554295033216476,
-0.029104888439178467,
-0.004464592318981886,
0.0027925511822104454,
0.01114576030522585,
0.028834041208028793,
-0.00552885327488184,
0.008175564929842949,
0.034316226840019226,
-0.024314798414707184,
0.003772342810407281,
0.021586809307336807,
0.015526623465120792,
0.008641962893307209,
0.006707502529025078,
0.0009219096973538399,
-0.008913419209420681,
-0.009763631969690323,
0.0022556185722351074,
0.022717854008078575,
-0.02560241147875786,
0.005236291792243719,
0.008150499314069748,
0.0030594333074986935,
-0.01374336238950491,
-0.001623391406610608,
-0.08168362081050873,
-0.015066348947584629,
0.020857755094766617,
0.011643998324871063,
0.009313158690929413,
-0.00931177195161581,
-0.0017574985977262259,
-0.009204053319990635,
0.0006062493775971234,
0.0063821179792284966,
0.002211126498878002,
0.0011503073619678617,
-0.012630578130483627,
0.022388366982340813,
-0.013936251401901245,
-0.001855469890870154,
0.016962382942438126,
-0.0075690895318984985,
-0.010028287768363953,
-0.0023506225552409887,
-0.011201991699635983,
0.0007129455916583538,
-0.0009222470689564943,
-0.008452141657471657,
-0.0023451729211956263,
-0.005858711898326874,
0.006604262627661228,
0.009457344189286232,
-0.007857163436710835,
0.006546230521053076,
0.02001291513442993,
0.0018775342032313347,
-0.009957654401659966,
-0.005664368160068989,
0.003468831069767475,
-0.0005368499550968409,
-0.013195430859923363,
0.007701527792960405,
0.0010632388293743134,
0.0005754842422902584,
-0.021487798541784286,
-0.0015280635561794043,
0.015957290306687355,
-0.019196590408682823,
-0.0006710185552947223,
0.024843230843544006,
-0.018816402181982994,
0.007976086810231209,
0.006823020521551371,
-0.00978362001478672,
-0.011292882263660431,
-0.016204267740249634,
-0.011227996088564396,
0.011159000918269157,
-0.015238707885146141,
0.0034148734994232655,
-0.017879225313663483,
-0.008956859819591045,
-0.007311562541872263,
0.002183519536629319,
-0.001529376721009612,
-0.00959603488445282,
-0.0016334946267306805,
0.017801379784941673,
0.0065477327443659306,
-0.00953019130975008,
-0.008397689089179039,
-0.00427588215097785,
0.000699671683833003,
-0.0023330384865403175,
-0.0047116754576563835,
-0.011492131277918816,
-0.006879438646137714,
-0.007895166054368019,
-0.010680346749722958,
-0.0047441450878977776,
-0.015560997650027275,
-0.008569616824388504,
-0.008323078975081444,
-0.005625929683446884,
-0.02121727168560028,
0.012732315808534622,
-0.017315814271569252,
0.002873244695365429,
-0.004051164723932743,
0.008067604154348373,
0.004284385591745377,
-0.01760897971689701,
0.006132567301392555,
-0.012741656973958015,
-0.012255583889782429,
-0.011476730927824974,
-0.003402295056730509,
0.01238144189119339,
0.016042931005358696,
-0.015460874885320663,
0.024539001286029816,
-0.002058961195871234,
0.028889555484056473,
0.009006721898913383,
0.032440897077322006,
-0.007319676224142313,
0.027041029185056686,
-0.008219444192945957,
-0.016563598066568375,
0.007594436407089233,
0.02026240900158882,
0.0014265626668930054,
-0.002294674050062895,
-0.013116436079144478,
0.022617008537054062,
-0.00401204451918602,
-0.0027732867747545242,
-0.011905629187822342,
0.008435692638158798,
-0.02230934239923954,
-0.009489119984209538,
-0.0029338286258280277,
0.07296369969844818,
0.0140540087595582,
0.026971660554409027,
-0.004536115564405918,
0.009097602218389511,
-0.035537347197532654,
-0.012401966378092766,
0.005293148569762707,
-0.0008071404881775379,
-0.015757184475660324,
0.010128435678780079,
0.016963066533207893,
-0.012444269843399525,
-0.013313885778188705,
0.025736048817634583,
-0.018785182386636734,
0.027594687417149544,
-0.009443744085729122,
0.01938401348888874,
-0.020387914031744003,
0.01836182363331318,
0.014648130163550377,
-0.013260516338050365,
-0.03238974139094353,
0.01413258071988821,
-0.026541782543063164,
0.016520816832780838,
-0.015807924792170525,
0.013958875089883804,
0.0012005531461909413,
-0.0019444883801043034,
0.014578670263290405,
-0.011534140445291996,
-0.005632500164210796,
0.010897276923060417,
0.011717050336301327,
0.01089668832719326,
-0.02147863805294037,
-0.011968755163252354,
-0.01620856299996376,
-0.012328095734119415,
-0.012369447387754917,
0.004708477295935154,
0.0043607233092188835,
0.013804086484014988,
0.0011733127757906914,
-0.02618139609694481,
-0.0040059275925159454,
-0.009440327063202858,
0.018934421241283417,
-0.005497465841472149,
0.007291227579116821,
0.012128176167607307,
-0.020370136946439743,
0.014845088124275208,
-0.03429434448480606,
2.949964255094528e-7,
-0.014598863199353218,
-0.03380821645259857,
0.012844094075262547,
0.0058836909011006355,
-0.01376284845173359,
0.021418388932943344,
-0.018336836248636246,
0.01046295277774334,
-0.010542651638388634,
0.01013922318816185,
0.005378200672566891,
0.03125747665762901,
0.01511305570602417,
-0.00920248031616211,
-0.007237418554723263,
-0.01986720971763134,
-0.007262892089784145,
-0.021824315190315247,
-0.023585451766848564,
0.010022452101111412,
0.006429213099181652,
-0.017269406467676163,
-0.0025281491689383984,
-0.026719700545072556,
-0.03264646232128143,
-0.00018976989667862654,
-0.023978017270565033,
-0.001702542882412672,
0.0019935239106416702,
0.018789969384670258,
-0.07457952946424484,
0.0011819659266620874,
0.007072295993566513,
-0.004663330968469381,
-0.003210492432117462,
0.004016103222966194,
-0.009433346800506115,
-0.00020045321434736252,
-0.0013567820424214005,
0.010707471519708633,
-0.018933488056063652,
0.00265871686860919,
0.002381878439337015,
-0.020923931151628494,
0.009045347571372986,
0.004934035707265139,
-0.0014743064530193806,
0.004289328586310148,
0.006288713309913874,
-0.007963189855217934,
0.004655131138861179,
-0.009067977778613567,
-0.004842714406549931,
0.010217081755399704,
-0.014239387586712837,
-0.08179564774036407,
-0.026960447430610657,
-0.00011232082033529878,
-0.044164229184389114,
-0.022056475281715393,
-0.0071571446023881435,
-0.0013022327329963446,
-0.011723613366484642,
0.005362390074878931,
-0.010956068523228168,
-0.0033130033407360315,
-0.012002967298030853,
0.009435558691620827,
0.0035698898136615753,
0.01749230921268463,
-0.013664999045431614,
-0.0016061104834079742,
-0.0024144090712070465,
0.0036165518686175346,
0.011517418548464775,
-0.018793372437357903,
0.0015082319732755423,
-0.0055175600573420525,
0.005888607352972031,
-0.002063280902802944,
-0.013467514887452126,
-0.0335862897336483,
0.013968518935143948,
0.010522214695811272,
-0.013517086394131184,
0.000282500172033906,
0.01962408423423767,
0.017483171075582504,
-0.02366195060312748,
0.009100604802370071,
0.00833836942911148,
0.00018695928156375885,
-0.010361460968852043,
-0.012335006147623062,
-0.017414601519703865,
0.011773843318223953,
-0.01201620139181614,
0.03328365832567215,
-0.0016120255459100008,
-0.006421261001378298,
-0.00032455800101161003,
0.00793202593922615,
-0.005365700926631689,
-0.01380946021527052,
0.032868534326553345,
0.013097141869366169,
-0.0225706584751606,
-0.02677949145436287,
0.03393195569515228,
-0.00817951187491417,
0.013041777536273003,
0.002267067786306143,
0.02334297075867653,
-0.010306542739272118,
-0.006490381900221109,
0.0021467390470206738,
-0.02198805660009384,
0.003283982165157795,
0.07182804495096207,
0.004362967796623707,
-0.012699606828391552,
0.006392786279320717,
-0.018563121557235718,
0.004087422974407673,
0.02258654125034809,
0.0029351534321904182,
-0.006859231740236282,
0.0017914660274982452,
-0.004600769840180874,
-0.012659883126616478,
-0.022044315934181213,
0.0009418494300916791,
0.02768448367714882,
-0.04324211925268173,
0.010534567758440971,
0.013686422258615494,
-0.005347963888198137,
0.013537758029997349,
-0.017990583553910255,
0.01560189202427864,
-0.01869424432516098,
-0.012590175494551659,
-0.01346336305141449,
0.00692957267165184,
-0.004683243576437235,
-0.016600174829363823,
0.027078256011009216,
0.0035618094261735678,
-0.012149505317211151,
-0.0003658561035990715,
0.0001560952514410019,
0.01546544674783945,
0.013731738552451134,
0.021900871768593788,
-0.014574689790606499,
0.015454137697815895,
0.0002852063626050949,
-0.01828521490097046,
0.0013857814483344555,
-0.010188430547714233,
0.01438424177467823,
0.009177852421998978,
0.028467055410146713,
-0.017525937408208847,
0.014565812423825264,
0.003289983607828617,
-0.005682056304067373,
-0.009862412698566914,
-0.011226405389606953,
0.018013564869761467,
-0.02029150165617466,
-0.01023055799305439,
0.009413087740540504,
0.026283008977770805,
0.0019152185413986444,
0.022417115047574043,
-0.009154352359473705,
-0.0038397989701479673,
-0.0023264018818736076,
-0.02033108100295067,
-0.024436162784695625,
-0.0159201230853796,
0.01202913373708725,
0.01594165712594986,
0.014318851754069328,
-0.017151933163404465,
0.004517310298979282,
0.010827342048287392,
-0.027732616290450096,
-0.007865296676754951,
0.0055828881449997425,
0.013017022982239723,
-0.008322834968566895,
0.004109593108296394,
-0.0006260639056563377,
0.005848916247487068,
0.010308044031262398,
-0.010014756582677364,
-0.007421337533742189,
-0.013899177312850952,
0.00019581965170800686,
-0.014407232403755188,
-0.001031635794788599,
-0.02736382931470871,
0.012148326262831688,
0.020541246980428696,
0.00478750467300415,
0.006322926841676235,
0.04065335914492607,
0.010406061075627804,
0.00009107182268053293,
-0.001160948071628809,
0.00890894141048193,
0.03333765268325806,
0.019357748329639435,
0.0007024563965387642,
0.009137667715549469,
-0.009187543764710426,
0.025225169956684113,
-0.003141348948702216,
0.014204829931259155,
-0.006192781962454319,
0.005768202245235443,
-0.011951981112360954,
0.007300442084670067,
-0.0028361384756863117,
-0.003436287632212043,
-0.006469586864113808,
-0.01442323811352253,
0.01424756832420826,
0.010530700907111168,
0.002990911016240716,
0.0063270097598433495,
-0.002524593146517873,
-0.018230538815259933,
0.006742545403540134,
0.012131755240261555,
-0.011995973996818066,
-0.0197923444211483,
0.007058085408061743,
0.002270385157316923,
-0.005261226557195187,
-0.0286224614828825,
-0.007183519192039967,
-0.00731355044990778,
0.008797859773039818,
0.007478252053260803,
-0.012028339318931103,
-0.011831458657979965,
0.008095202967524529,
0.030368398874998093,
-0.008569957688450813,
0.002496944973245263,
0.007802424021065235,
0.01673717051744461,
-0.0055799526162445545,
-0.015373755246400833,
0.0004732537781819701,
-0.014795716851949692,
-0.0023364457301795483,
0.002821015426889062,
-0.015923675149679184,
0.008590765297412872,
-0.034468576312065125,
0.005809511058032513,
0.021685924381017685,
0.003157801227644086,
-0.03262712061405182,
0.027319172397255898,
0.011861923150718212,
-0.016908938065171242,
-0.009880753234028816,
0.0011488820891827345,
0.004286032635718584,
0.007480770815163851,
-0.01881982572376728,
0.00305545749142766,
0.0069534857757389545,
-0.004656251519918442,
0.022561781108379364,
0.04873134195804596,
0.018531467765569687,
-0.008865331299602985,
0.034185029566287994,
-0.012077311053872108,
0.004194304812699556,
0.0004149898886680603,
-0.022766469046473503,
0.02785344608128071,
0.014147136360406876,
-0.007658593822270632,
-0.0028504622168838978,
0.008918263018131256,
-0.016275808215141296,
-0.0071592628955841064,
0.020977716892957687,
0.0020990250632166862,
-0.011133529245853424,
0.002179054543375969,
0.028572097420692444,
-0.0005862286780029535,
-0.010983552783727646,
0.0019575206097215414,
0.027680207043886185,
-0.006810892838984728,
0.015107695944607258,
-0.00894315168261528,
-0.0015773980412632227,
-0.006802702322602272,
-0.0012117912992835045,
-0.0034125177189707756,
0.017548877745866776,
0.0007326975464820862,
-0.0150402020663023,
-0.008253107778728008,
0.03990854322910309,
0.0016474415315315127,
0.015134153887629509,
0.018819399178028107,
-0.010497196577489376
] | [
-0.017515983432531357,
0.41311654448509216,
-0.2926173508167267,
-0.528899610042572,
-0.2876572012901306,
-0.0373799167573452,
0.2424720674753189,
-0.11493732035160065,
0.027582859620451927,
-0.3573814034461975,
-0.10690733045339584,
0.6217047572135925,
-0.1495850533246994,
0.061558838933706284,
0.04900943115353584,
0.36328989267349243,
0.5089614987373352,
-0.3137337267398834,
-0.8144999742507935,
-0.32204872369766235,
-0.04547553509473801,
-0.10157392174005508,
0.04009217768907547,
0.4254727363586426,
-0.370792031288147,
0.35708633065223694,
0.5457100868225098,
0.14239603281021118,
-0.2334601730108261,
0.10666359215974808,
-0.26119402050971985,
0.6373884677886963,
-0.1911747306585312,
-0.40852561593055725,
-0.32859137654304504,
0.6411866545677185,
0.1647103875875473,
0.12959913909435272,
0.19974026083946228,
0.002573553938418627,
0.23286072909832,
0.32330211997032166,
-0.4156549274921417,
0.153700590133667,
-0.3213335871696472,
0.415561318397522,
-1.5985190868377686,
-0.41774997115135193,
-0.5687766075134277,
-0.19759364426136017,
-0.14097990095615387,
0.1580219268798828,
0.8838908076286316,
0.42617639899253845,
-0.15516987442970276,
0.259813129901886,
-0.6067160964012146,
-0.3353152871131897,
-0.12326912581920624,
-0.3242470622062683,
0.30249831080436707,
0.09948965907096863,
0.3357793092727661,
0.32789286971092224,
-0.11365283280611038,
0.314997136592865,
-0.167653426527977,
0.3080301880836487,
-0.4460931122303009,
0.11379043012857437,
-0.04418742656707764,
-0.6629258990287781,
0.18214865028858185,
0.11875051259994507,
0.05698305740952492,
0.24234649538993835,
0.00970425270497799,
-0.6559310555458069,
0.1742631494998932,
-0.0076777213253080845,
-0.14719407260417938,
-0.15889397263526917,
1.0002107620239258,
-0.6752638220787048,
0.23589962720870972,
0.11704954504966736,
-0.07451227307319641,
0.4064897894859314,
0.05777565762400627,
0.2512725591659546,
-0.12207352370023727,
-0.548698365688324,
0.29733794927597046,
0.17175735533237457,
0.6501938700675964,
0.1808180958032608,
0.7162176370620728,
0.48891744017601013,
-0.09360252320766449,
0.18965867161750793,
0.2958228588104248,
0.2710263431072235,
0.29717400670051575,
-0.20404817163944244,
-0.6131796836853027,
-0.42305395007133484,
0.012303070165216923,
-0.670238196849823,
-0.14558354020118713,
0.6230683922767639,
-0.6408966779708862,
0.21596884727478027,
-0.05954980105161667,
-0.11828672140836716,
-0.3520249128341675,
0.28787583112716675,
-0.06403959542512894,
-0.3951002061367035,
-0.1482214480638504,
0.507063090801239,
0.14282257854938507,
0.6042317152023315,
0.6239645481109619,
0.23406587541103363,
0.10677551478147507,
-0.11984410136938095,
0.2821514904499054,
0.6140785813331604,
-0.3460930585861206,
0.09523143619298935,
-0.10722102224826813,
0.504035234451294,
0.04263349995017052,
-0.07043399661779404,
-0.036594271659851074,
-0.18958596885204315,
0.22500614821910858,
0.06355588138103485,
-0.6967517137527466,
0.28038290143013,
-0.016115842387080193,
-0.259549081325531,
-0.7703210711479187,
-0.3709411025047302,
-0.31025150418281555,
-0.14878566563129425,
0.1507369726896286,
0.07130435854196548,
-0.020150523632764816,
-0.34820833802223206,
-0.09109513461589813,
0.31692248582839966,
-0.30060669779777527,
-0.3836154639720917,
0.3704410791397095,
0.7425982356071472,
-0.15276537835597992,
0.13100352883338928,
0.7058236002922058,
-0.269529789686203,
0.12374504655599594,
-0.011648347601294518,
-0.0485105961561203,
0.1760769635438919,
0.19160254299640656,
-0.5155730843544006,
0.42473408579826355,
-0.05638910457491875,
0.1787387877702713,
-0.18516972661018372,
-0.26464390754699707,
-0.1402202993631363,
-0.037210896611213684,
-0.17618964612483978,
-0.24275799095630646,
0.5821176767349243,
1.22250497341156,
0.9954934120178223,
-0.06536749750375748,
-0.39315858483314514,
-0.728280246257782,
-0.3494831621646881,
0.16427691280841827,
-0.36038804054260254,
0.730402946472168,
0.045332442969083786,
0.12710623443126678,
-0.04655754566192627,
0.3031075596809387,
0.3672608435153961,
0.07774408906698227,
0.11512582749128342,
0.3825434148311615,
-0.44312214851379395,
1.0829659700393677,
0.29897475242614746,
-0.31336510181427,
1.4509810209274292,
-0.1493009626865387,
0.620165228843689,
0.3604769706726074,
0.08649182319641113,
0.024539189413189888,
0.2875460684299469,
0.18018460273742676,
0.07764100283384323,
-0.23142091929912567,
0.08279912173748016,
-0.4869123101234436,
0.2813977301120758,
0.5809574723243713,
-0.29767996072769165,
-0.27109748125076294,
0.15975485742092133,
-0.3947872221469879,
0.3807833194732666,
0.09482525289058685,
0.16078618168830872,
-0.024702545255422592,
-0.2388390153646469,
0.8707001209259033,
0.05754745751619339,
0.32820963859558105,
0.48817139863967896,
0.19916899502277374,
0.8145111799240112,
0.3562464714050293,
0.1660032719373703,
0.3802798092365265,
-0.7184226512908936,
-0.07278604060411453,
-0.0711546242237091,
0.7393692135810852,
-0.10308167338371277,
0.45587196946144104,
0.35635906457901,
-0.12790599465370178,
-0.5156821608543396,
-0.3924289047718048,
-0.4703136682510376,
0.7909401059150696,
-0.561884343624115,
-0.026026247069239616,
0.8754445314407349,
0.29516103863716125,
-0.19447925686836243,
0.06722531467676163,
0.6096339821815491,
-0.45678502321243286,
0.14937889575958252,
0.57878178358078,
0.3653499484062195,
0.1298835575580597,
-0.04624701291322708,
-0.06174336373806,
0.12725846469402313,
-0.5588602423667908,
-0.08836661279201508,
0.37382882833480835,
0.2520042359828949,
0.34698402881622314,
-0.017121391370892525,
-0.29543930292129517,
-0.09408792853355408,
-0.45824357867240906,
-0.670669674873352,
-0.25533902645111084,
-0.5294959545135498,
0.04715070500969887,
0.031232092529535294,
-0.297309935092926,
0.31013667583465576,
-0.549308717250824,
0.4012748599052429,
-0.4759903848171234,
-0.5775818228721619,
-0.43463292717933655,
0.00719961104914546,
-0.5982547998428345,
-0.17541790008544922,
0.17423559725284576,
0.5624995231628418,
0.4541773200035095,
0.01038405392318964,
-0.8575667142868042,
-0.5965667963027954,
0.28275737166404724,
-0.8483259081840515,
-0.3028024137020111,
0.47917354106903076,
0.08538098633289337,
0.5261600017547607,
-0.0077924844808876514,
-0.9644157886505127,
0.06329001486301422,
0.5718756914138794,
0.07271070033311844,
-0.17239481210708618,
0.1292559653520584,
-0.08909983932971954,
-0.4825744330883026,
0.30596739053726196,
-0.12979945540428162,
0.2852804362773895,
0.024900205433368683,
-0.45038387179374695,
-0.5536180138587952,
0.16081850230693817,
-5.906329154968262,
-0.2536972761154175,
-0.3747116029262543,
-0.24134159088134766,
-0.16696831583976746,
0.10437487065792084,
0.32307353615760803,
-0.34281355142593384,
-0.2186262309551239,
-0.24433408677577972,
0.18707092106342316,
0.5062246918678284,
0.31836575269699097,
0.9158902764320374,
0.12904776632785797,
0.3180575966835022,
-0.0013767456403002143,
0.10060159116983414,
-0.27966511249542236,
0.016927633434534073,
0.2562118470668793,
-0.14201605319976807,
0.06975093483924866,
0.23403117060661316,
-0.12540891766548157,
0.7755441665649414,
-0.45042872428894043,
0.7030202746391296,
-0.1355411261320114,
0.15660904347896576,
0.062195297330617905,
-0.28912240266799927,
-0.4933088421821594,
0.021785451099276543,
0.17819200456142426,
0.2834293842315674,
0.13536402583122253,
0.1112457737326622,
-0.01338091492652893,
-0.13105641305446625,
0.1842624992132187,
0.27288249135017395,
-0.0707039088010788,
-0.583572506904602,
0.26335465908050537,
0.01895534247159958,
-0.5164838433265686,
0.003603813238441944,
-0.5656611323356628,
0.5309247374534607,
-0.07758640497922897,
-0.385848730802536,
0.15858455002307892,
0.30052924156188965,
0.12369687855243683,
-0.5486157536506653,
0.05684066563844681,
-0.019641630351543427,
-0.2407875508069992,
0.33046144247055054,
-0.4488856792449951,
-0.19442850351333618,
-0.1640971601009369,
-0.6471693515777588,
-0.5204070806503296,
0.4166054427623749,
-0.6559540033340454,
-0.553324282169342,
0.44093582034111023,
0.45622125267982483,
-0.2755778729915619,
0.35064277052879333,
0.32536816596984863,
-0.7646288275718689,
0.032018836587667465,
-0.45279213786125183,
-0.12034913897514343,
0.0011191717348992825,
-0.26388806104660034,
0.4612923860549927,
-0.05323217064142227,
-0.2863985300064087,
-0.15549032390117645,
0.19639886915683746,
0.45648589730262756,
-0.038450632244348526,
-0.23191705346107483,
0.3299735188484192,
-0.45432350039482117,
0.07257702201604843,
0.12209425121545792,
-0.20586583018302917,
-0.19118690490722656,
0.28436166048049927,
0.13010594248771667,
0.5968908667564392,
-0.2186076045036316,
0.22368399798870087,
0.8399471044540405,
-0.5455214977264404,
0.7736138105392456,
-0.6258289217948914,
0.49606797099113464,
-0.7604114413261414,
0.08845251053571701,
-0.2768639028072357,
-0.8488495349884033,
0.013341024518013,
0.7443451881408691,
-0.20613574981689453,
-0.052770160138607025,
-0.25636258721351624,
-0.03927045315504074,
-0.37847423553466797,
0.7315694689750671,
-0.24681702256202698,
-0.19872978329658508,
0.007480515167117119,
-0.1637466996908188,
0.23321154713630676,
-0.0887293890118599,
-0.045984216034412384,
0.03777642920613289,
-0.611235499382019,
-0.19699694216251373,
0.1354798972606659,
0.347362756729126,
-0.03794964402914047,
-0.007889055646955967,
0.47796469926834106,
0.1647857129573822,
0.24428382515907288,
0.26375916600227356,
0.6090149283409119,
0.4488610029220581,
-0.5402051210403442,
-0.9105834364891052,
-0.05150502547621727,
-0.16057446599006653,
-0.13585850596427917,
0.5049718618392944,
0.15796685218811035,
-0.09648746252059937,
0.1330682337284088,
-0.08544322848320007,
-0.0008182026795111597,
-0.4255411922931671,
-0.05360429361462593,
-0.09857866913080215,
0.20997168123722076,
0.5082823634147644,
-0.5270116329193115,
0.26562392711639404,
0.02166399545967579,
-0.44886407256126404,
0.96257483959198,
0.09941215813159943,
0.6451452970504761,
-0.39299216866493225,
-0.1472748965024948,
0.21377108991146088,
-0.2445167750120163,
-0.6985794305801392,
-0.08992122858762741,
0.7824264764785767,
0.26127973198890686,
-0.3840528130531311,
-0.2784861624240875,
-0.12249530851840973,
0.2426234632730484,
0.24233144521713257,
-0.27587026357650757,
-0.28278058767318726,
-0.5306052565574646,
0.6684501767158508,
0.5368390083312988,
-0.22048884630203247,
0.3686389625072479,
0.11691281199455261,
0.0027042338624596596,
0.43049073219299316,
-0.9401592016220093,
-0.6705655455589294,
0.2993479073047638,
0.5235322117805481,
0.0877745971083641,
0.24959416687488556,
-0.44150468707084656,
-0.5658416152000427,
0.05773896723985672,
0.3618190288543701,
0.07397664338350296,
0.26587074995040894,
0.21838973462581635,
-0.21975041925907135,
-0.7231978178024292,
0.3809225261211395,
-0.4242442548274994,
-0.11293008178472519,
-0.23941589891910553,
0.020452778786420822,
0.6486210227012634,
-0.19910672307014465,
0.21445246040821075,
0.6126062273979187,
-1.0139753818511963,
-0.04530014470219612,
-0.2386128455400467,
-0.37042173743247986,
0.5426693558692932,
-0.1897679716348648,
-0.25356265902519226,
0.04113554209470749,
0.11359734833240509,
0.08373747020959854,
-0.06756286323070526,
0.10810184478759766,
-0.5359938740730286,
-0.5237886905670166,
0.2269466072320938,
-0.008753472939133644,
0.07086748629808426,
-0.426959753036499,
-0.0014858500799164176,
-0.40794694423675537,
-0.22067654132843018,
0.4946634769439697,
-0.3511849343776703,
-0.15773379802703857,
-0.3738075792789459,
-0.22064298391342163,
0.22776250541210175,
0.03865968436002731,
0.11643733084201813,
-0.03434580937027931,
-0.5424492359161377,
0.4859185218811035,
0.3625006079673767,
-0.31899064779281616,
0.09400571137666702,
0.2721253037452698,
0.46760889887809753,
0.3082611858844757,
-0.2746347486972809,
-0.013856721110641956,
-0.6226217746734619,
0.2362271249294281,
-0.5648677349090576,
-0.8947439193725586,
0.3019467294216156,
-0.09530655294656754,
-0.039984941482543945,
-0.30430278182029724,
-0.47129446268081665,
0.9094077348709106,
-0.4677705466747284,
-0.2503841519355774,
-0.31076258420944214,
-0.14811965823173523,
-0.20898988842964172,
0.0074036819860339165,
0.23364967107772827,
-0.41638636589050293,
-0.5535057187080383,
0.2540575861930847,
0.47521597146987915,
-0.2571620047092438,
-0.7473827004432678,
0.1659090518951416,
-0.7352932691574097,
0.054201386868953705,
-0.43453627824783325,
-0.20266161859035492,
-0.008117354474961758,
0.4015686810016632,
0.5420746207237244,
-0.20147594809532166,
0.10348612815141678,
-0.13717161118984222,
-0.10961969941854477,
0.14636631309986115,
-0.06601451337337494,
0.037676647305488586,
-0.34929323196411133,
-0.12164194881916046,
-0.38532477617263794,
-0.1911451369524002,
-0.30274543166160583,
0.3526449203491211,
-0.06589634716510773,
-0.09410304576158524,
0.03977668657898903,
-0.13482125103473663,
-0.33731186389923096,
-0.2707750201225281,
0.26784929633140564,
0.15122412145137787,
0.21690987050533295,
-0.4330666661262512,
-0.3084321916103363,
0.35186898708343506,
0.4874122738838196,
0.30394643545150757,
-0.3947374224662781,
-0.16170376539230347,
0.11063714325428009,
0.3205948770046234,
0.3966341018676758,
-0.4751083552837372,
0.44801318645477295,
0.18809601664543152,
-0.1692836880683899,
-0.21381865441799164,
0.931045651435852,
-0.838690996170044,
-0.1610545516014099,
0.44244682788848877,
0.027602387592196465,
0.2540813088417053,
0.3068861663341522,
0.543158233165741,
0.48753854632377625,
0.6198744773864746,
-0.24106931686401367,
-1.0145353078842163,
0.45522427558898926,
-0.5020711421966553,
0.30417564511299133,
-0.4274885356426239,
0.07135260105133057,
0.6829544305801392,
0.472517192363739,
-0.15208199620246887,
0.27834731340408325,
0.13357499241828918,
-0.047165676951408386,
0.5297074317932129,
-0.3404962122440338,
-0.4020068645477295,
-0.13642381131649017,
0.2535110414028168,
0.7950416207313538,
0.10328679531812668,
0.3725299537181854,
-0.10463263094425201,
-0.010762982070446014,
-0.2388598918914795,
0.0233208816498518,
0.01610550843179226,
0.04605109989643097,
0.369596391916275,
0.4052836000919342,
0.08316277712583542,
-0.17723749577999115,
-0.2157236784696579,
-0.08343346416950226,
0.11571955680847168,
-0.7370046973228455,
0.025555657222867012,
0.27330827713012695,
0.02805115096271038,
0.11890910565853119,
-0.25317391753196716,
0.3912292718887329,
0.10938160866498947,
0.28932487964630127,
0.611235499382019,
-0.27466580271720886,
-0.38844406604766846,
0.12289540469646454,
-0.5919855833053589,
-0.3161253035068512,
0.03503967449069023,
0.3640921115875244,
-0.349136620759964,
-0.8224388957023621,
0.47791776061058044,
-0.0547063983976841,
0.05596098676323891,
0.5001022815704346,
-0.1579209417104721,
-0.2741253972053528,
-0.2698713541030884,
-0.29431283473968506,
0.6791332960128784,
-0.2524609863758087,
-0.13854815065860748,
0.11091319471597672,
0.17320756614208221,
-0.053212061524391174,
-0.07487613707780838,
-0.5648071765899658,
-0.8899987936019897,
0.048698052763938904,
-0.20908202230930328,
-0.41682302951812744,
-0.15672393143177032,
0.38198092579841614,
0.21489955484867096,
0.16972018778324127,
-0.24566572904586792,
0.0021585035137832165,
0.4237810969352722,
0.564100980758667,
-0.6137301921844482,
0.28396594524383545,
-0.5449544191360474,
0.29991090297698975,
-0.6770796179771423,
0.34551918506622314,
-0.5218761563301086,
0.590088963508606,
-0.7677247524261475,
-0.036144133657217026,
-0.2602105140686035,
-0.07216865569353104,
0.11119049787521362,
-0.3768182098865509,
-0.0075205592438578606,
-0.24643287062644958,
-0.22166454792022705,
-0.037768058478832245,
0.39418351650238037,
0.4869973659515381,
0.18227322399616241,
-0.12166263163089752,
0.07997513562440872,
-0.12403097748756409,
-0.01870006136596203,
0.25719961524009705,
0.1749051958322525,
-0.3745078146457672,
-0.07551255077123642,
-0.19866807758808136,
-0.704879105091095,
-0.47894319891929626,
0.3583066463470459,
-0.20964184403419495,
0.11779343336820602,
-0.36533600091934204,
-0.28747475147247314,
0.08927593380212784,
-0.4767428934574127,
0.8429904580116272,
0.017307046800851822,
0.2731301188468933,
-0.1879706233739853,
-0.7860018610954285,
0.25327980518341064,
0.8230493068695068,
-0.10176192224025726,
0.45396649837493896,
-0.06570933759212494,
-0.4824006259441376,
0.10377731919288635,
0.374299556016922,
-0.2786347568035126,
-0.41140758991241455,
0.18934684991836548,
-0.24083884060382843
] |
Background: Family doctors play an important role in the health care for terminal ill and patients. The current level of palliative care in Germany is strongly criticised, however, empirical data is scare, particularly with respect to family doctors. Methods: Therefore, the attitudes of family doctors (sample: n= 257) in four representative regions in Lower Saxony were studied by using semi-structured telephone interviews. This was part of a health system researchers’ expert report. Results: 71doctors could be interviewed (28%). On the average, they cared for four palliative patients with cancer diseases and eight palliative patients with other diseases than cancer at that time. Many of the doctors were available for their patients around the clock, particularly in the final phase. The main area for improvement was considered to be the psychosocial support – rather than pain therapy, which is usually focussed. Furthermore, a considerable openness for the establishment of new palliative care structures was shown. Conclusion: Family doctors are highly motivated for palliative care and open for improvements. In the process, the diversity of opinion among professions and disciplines about the current situation and the further development of palliative care should be respected and considered. | [
-0.008298764936625957,
0.020651038736104965,
-0.007581109646707773,
0.019216381013393402,
-0.014819974079728127,
0.0027016561944037676,
0.006503697484731674,
-0.01601039431989193,
-0.016817260533571243,
-0.015080802142620087,
0.008179332129657269,
0.011738247238099575,
0.014654362574219704,
0.003872876986861229,
0.023143013939261436,
-0.002721628174185753,
-0.01315291691571474,
-0.004651258233934641,
0.008210926316678524,
-0.015748441219329834,
0.02886378951370716,
0.019345607608556747,
0.009160897694528103,
0.008248573169112206,
-0.018407046794891357,
0.007584379520267248,
0.006623895838856697,
0.0024033188819885254,
0.02729046903550625,
0.02720743417739868,
-0.01617758348584175,
0.004787706770002842,
0.0003115106374025345,
-0.016608241945505142,
0.018650025129318237,
-0.0005224408814683557,
0.006150906905531883,
0.019221331924200058,
-0.03316781669855118,
-0.00294130714610219,
0.009514627046883106,
0.005174826830625534,
-0.009917211718857288,
0.0151813430711627,
-0.006616965867578983,
0.030071299523115158,
-0.00515106413513422,
-0.01682269014418125,
-0.013682973571121693,
0.007490003481507301,
-0.009972518309950829,
-0.0019386300118640065,
-0.009275643154978752,
-0.024293202906847,
-0.005028904881328344,
0.009401597082614899,
0.018326202407479286,
0.0121575016528368,
-0.0006986435037106276,
0.030973508954048157,
-0.004330362658947706,
-0.018774259835481644,
0.017712503671646118,
0.01010957546532154,
-0.02105213701725006,
-0.06723129749298096,
0.0014633890241384506,
-0.0038428371772170067,
0.010067107155919075,
-0.0301523320376873,
0.009544084779918194,
0.008155654184520245,
0.02867470495402813,
0.015058767981827259,
-0.025205552577972412,
0.004839921370148659,
0.004233012907207012,
0.02259346842765808,
-0.0045296018943190575,
-0.021535638719797134,
-0.03545873612165451,
-0.0014598736306652427,
0.004106823820620775,
0.021882159635424614,
-0.011226249858736992,
0.011915850453078747,
-0.013907471671700478,
-0.008863260969519615,
0.0006596501916646957,
0.018400518223643303,
0.009979915805161,
0.012316117994487286,
0.025712860748171806,
-0.01115800067782402,
-0.0122962836176157,
-0.0011221105232834816,
-0.022212279960513115,
-0.016623061150312424,
0.003991111181676388,
0.015454272739589214,
0.01174786314368248,
0.010536755435168743,
0.014947955496609211,
0.02435288578271866,
-0.00949364248663187,
0.00888996385037899,
0.009364137426018715,
-0.00432467320933938,
-0.012776672840118408,
0.004200653173029423,
0.00410042516887188,
0.005244702100753784,
-0.016970280557870865,
-0.018400700762867928,
-0.012177756056189537,
-0.0057542468421161175,
-0.01434400025755167,
0.021425530314445496,
0.008136849850416183,
-0.013073588721454144,
-0.0038437843322753906,
-0.011487659066915512,
-0.0061418055556714535,
0.012976771220564842,
0.0004262218135409057,
0.018717553466558456,
0.02171308547258377,
-0.014878174290060997,
0.006790832616388798,
0.010485216975212097,
-0.007027359679341316,
-0.006736348383128643,
0.015854988247156143,
0.012357665225863457,
0.012656286358833313,
-0.017850765958428383,
0.0041868421249091625,
0.022348804399371147,
0.0055397069081664085,
-0.00865798071026802,
-0.010903017595410347,
0.008981788530945778,
0.000986031023785472,
0.005975288338959217,
-0.026173461228609085,
-0.005479516927152872,
-0.006892552599310875,
0.004210871644318104,
0.004923839122056961,
0.006668515037745237,
-0.006225229240953922,
0.016407238319516182,
0.011756043881177902,
-0.01799844205379486,
0.014972162432968616,
-0.0037380214780569077,
-0.020229652523994446,
-0.019360914826393127,
-0.015119352377951145,
0.015208646655082703,
0.006104594562202692,
0.00002639682497829199,
0.009564429521560669,
0.007991872727870941,
0.016453959047794342,
-0.012932517565786839,
0.00302028376609087,
-0.01570923440158367,
-0.017247529700398445,
0.004882658366113901,
-0.006134039256721735,
0.007521756924688816,
-0.0024163390044122934,
0.007540279068052769,
-0.0066927773877978325,
0.003269582986831665,
-0.004750326741486788,
0.007029534317553043,
-0.005710937548428774,
0.06667304039001465,
-0.014528174884617329,
0.0009075297275558114,
-0.013283384963870049,
-0.04026879370212555,
0.040036387741565704,
0.006391733419150114,
-0.005917842965573072,
-0.006999926175922155,
-0.0040623825043439865,
-0.005756356753408909,
0.008004697039723396,
-0.0054176608100533485,
0.0051932078786194324,
0.006094320211559534,
0.015650833025574684,
0.0035524056293070316,
-0.02006908506155014,
0.004116946831345558,
0.00864163227379322,
-0.0056800516322255135,
-0.007491213269531727,
0.00784507766366005,
0.005841832607984543,
-0.0054279654286801815,
-0.003229654859751463,
0.03478110581636429,
0.021656837314367294,
-0.0014688303926959634,
0.030608855187892914,
0.0056770071387290955,
0.013035617768764496,
0.0023630899377167225,
-0.010202386416494846,
0.0019420702010393143,
-0.006396671291440725,
0.005228767171502113,
-0.021020254120230675,
-0.0025221342220902443,
0.002053523436188698,
-0.018354643136262894,
0.0007840197067707777,
0.012014450505375862,
-0.03100048378109932,
0.006863287650048733,
0.002182692289352417,
-0.0169867854565382,
0.013874110765755177,
0.00856518093496561,
-0.0034304510336369276,
0.010924777947366238,
-0.020945202559232712,
-0.005986647680401802,
-0.0022913061548024416,
-0.004829738289117813,
0.007450345903635025,
0.011385335586965084,
0.008684329688549042,
-0.010490933433175087,
0.014415379613637924,
-0.009201360866427422,
-0.005370948929339647,
-0.03585630655288696,
0.010038819164037704,
0.019291745498776436,
0.0006207810947671533,
-0.007961137220263481,
-0.0073645273223519325,
-0.015108288265764713,
0.015740351751446724,
-0.010539179667830467,
0.0011321655474603176,
0.023370347917079926,
0.0023671118542551994,
-0.012060418725013733,
0.012110142968595028,
0.003250370966270566,
0.00481139263138175,
-0.022801779210567474,
0.0223761647939682,
-0.007965141907334328,
0.012205101549625397,
0.006034476682543755,
-0.008968327194452286,
-0.008810050785541534,
-0.010531947016716003,
0.010241025127470493,
0.002013180172070861,
0.0017239348962903023,
0.027710240334272385,
0.0010358764557167888,
0.0055770850740373135,
-0.003812312614172697,
0.005638989619910717,
-0.08157014101743698,
-0.005967681296169758,
0.0018856939859688282,
-0.009791724383831024,
0.006676254794001579,
0.009149998426437378,
0.015602154657244682,
0.01702452078461647,
0.0022743409499526024,
0.009654540568590164,
0.0293127428740263,
0.006053269375115633,
-0.008569633588194847,
-0.012847194448113441,
0.014735536649823189,
-0.0036722994409501553,
-0.0037363888695836067,
0.015721701085567474,
0.0022404459305107594,
-0.008752865716814995,
0.00393079686909914,
0.016094261780381203,
0.032456714659929276,
0.0009602950885891914,
0.011217465624213219,
0.013556941412389278,
0.017955780029296875,
-0.008196785114705563,
0.01061055064201355,
0.004603179637342691,
-0.0026801438070833683,
-0.02544146031141281,
0.0031544140074402094,
-0.0015275515615940094,
0.014681173488497734,
-0.008683109655976295,
-0.006971082650125027,
0.023402662947773933,
-0.013937635347247124,
-0.0013273935765028,
0.007770750671625137,
0.01670037768781185,
-0.01133660413324833,
-0.013939050026237965,
0.00027496227994561195,
0.020681101828813553,
-0.0032016688492149115,
0.004338373895734549,
0.008693869225680828,
-0.0012724983971565962,
-0.011671733111143112,
-0.015236525796353817,
0.011543899774551392,
0.0020109000615775585,
-0.006420139688998461,
0.002430732361972332,
0.0005854438059031963,
-0.017279939725995064,
-0.014730766415596008,
-0.0094396211206913,
-0.03736297786235809,
-0.015587610192596912,
0.005668522324413061,
-0.023729577660560608,
-0.006653829477727413,
0.009077928960323334,
0.007256983779370785,
-0.0012600691989064217,
-0.021415121853351593,
-0.013266291469335556,
0.028142742812633514,
-0.022613633424043655,
0.0022044251672923565,
-0.005372596438974142,
0.02019112929701805,
0.001366137177683413,
-0.014915655367076397,
-0.0014487644657492638,
0.01975196972489357,
0.02062833309173584,
-0.0007935045287013054,
-0.0024417820386588573,
-0.008115715347230434,
0.009658731520175934,
-0.025137096643447876,
-0.0312650203704834,
0.009397605434060097,
0.009298613294959068,
0.013617249205708504,
-0.012229540385305882,
-0.004362682346254587,
-0.019070353358983994,
-0.011979140341281891,
0.004686943721026182,
-0.003243647050112486,
-0.0009787846356630325,
0.013647682964801788,
-0.008874498307704926,
0.003665782045572996,
0.007290340028703213,
0.009593812748789787,
0.0012794723734259605,
0.007792863994836807,
-0.010202867910265923,
-0.020663579925894737,
0.011090580374002457,
0.017272667959332466,
-0.02129005454480648,
0.00413148570805788,
-0.015597796998918056,
-0.0007829566020518541,
0.00428207078948617,
-0.006581162102520466,
0.0006866331677883863,
0.006566231604665518,
-0.009391902945935726,
0.006687245797365904,
0.0014599179849028587,
0.07283137738704681,
0.008192809298634529,
0.015213804319500923,
-0.005357983522117138,
-0.019329894334077835,
-0.0021929508075118065,
-0.04414435476064682,
0.005477615632116795,
0.021673355251550674,
-0.014585582539439201,
0.010687178000807762,
-0.0006193835288286209,
0.010726647451519966,
-0.02113688364624977,
-0.010436974465847015,
0.02470054104924202,
0.0018951930105686188,
0.00695357471704483,
0.012593422085046768,
0.0011638477444648743,
0.0016204656567424536,
-0.011417659930884838,
-0.0016695111989974976,
0.007029723841696978,
0.011325201019644737,
-0.012585034593939781,
-0.0010127690620720387,
-0.012478885240852833,
0.008658302947878838,
-0.0008155497489497066,
-0.0012575876899063587,
0.026779143139719963,
-0.0013511155266314745,
0.019785704091191292,
0.028739213943481445,
0.0034120683558285236,
-0.037261735647916794,
0.00004918570630252361,
0.004684439394623041,
-0.010052552446722984,
-0.0001723533496260643,
-0.011553777381777763,
-0.005961759947240353,
0.008112473413348198,
0.00266472389921546,
0.009936472401022911,
-0.02132073976099491,
-0.005344438832253218,
-0.024186644703149796,
0.019367288798093796,
-0.0005244510248303413,
0.015713736414909363,
0.009572330862283707,
0.01716061867773533,
-0.009905382990837097,
-0.0152423195540905,
0.011987496167421341,
-0.009688465856015682,
-0.0006404160521924496,
0.02160826325416565,
0.010851195082068443,
0.00680103525519371,
0.013644656166434288,
-0.0285099558532238,
-0.011116797104477882,
-0.006493824068456888,
-0.0010426309891045094,
-0.023870905861258507,
0.014569791033864021,
-0.004257207736372948,
0.004093430936336517,
-0.02291119284927845,
-0.009806295856833458,
-0.0019128709100186825,
-0.014531474560499191,
0.016867078840732574,
-0.006639094091951847,
-0.014784712344408035,
0.02713664621114731,
-0.018973879516124725,
-0.00009621429489925504,
-0.0023113784845918417,
0.007419690489768982,
0.003625002223998308,
0.0022023585624992847,
0.007245034910738468,
-0.02314676158130169,
-0.07486288249492645,
0.007869082503020763,
-0.008424988016486168,
-0.010031189769506454,
-0.017568439245224,
-0.009006676264107227,
-0.01190515048801899,
-0.012887460179626942,
-0.012535249814391136,
-0.011338546872138977,
-0.03232307359576225,
0.022645259276032448,
0.005381512455642223,
-0.0033717979677021503,
0.012163983657956123,
0.017401061952114105,
0.0019463032949715853,
-0.004258062224835157,
-0.01193336583673954,
-0.009169094264507294,
0.01136225275695324,
0.026506975293159485,
-0.019774634391069412,
0.011613884940743446,
0.012285066768527031,
-0.08190292119979858,
0.0008094130316749215,
-0.01416358444839716,
-0.031174618750810623,
-0.014352474361658096,
-0.03307078033685684,
0.0020165806636214256,
-0.00982584897428751,
-0.024768561124801636,
-0.016160480678081512,
0.0025796343106776476,
-0.0036265328526496887,
0.005739609710872173,
-0.008440615609288216,
-0.009662298485636711,
-0.003428592812269926,
0.013518220745027065,
0.008668380789458752,
0.004654928110539913,
-0.011949336156249046,
-0.008047730661928654,
0.003631545463576913,
-0.0068910871632397175,
0.015521789900958538,
-0.00035908445715904236,
-0.005699503235518932,
0.0002935202792286873,
0.00818040780723095,
0.0010778587311506271,
-0.004641451872885227,
0.015843898057937622,
-0.003075316548347473,
-0.0014612885424867272,
-0.0036857272498309612,
0.002690734574571252,
-0.010593976825475693,
0.005370334256440401,
-0.012041887268424034,
-0.0070914397947490215,
0.0017054742202162743,
0.0010921356733888388,
0.03165004029870033,
-0.004144895821809769,
0.015322975814342499,
0.017217401415109634,
-0.014204914681613445,
0.006340493448078632,
0.002644880907610059,
0.007616243325173855,
0.005322445649653673,
0.00894390232861042,
0.007148134522140026,
0.006871188059449196,
-0.005409225355833769,
-0.022264203056693077,
0.003753615077584982,
-0.003186028217896819,
0.004632097668945789,
0.007024616934359074,
0.002400883473455906,
-0.004906633868813515,
-0.024602390825748444,
-0.010884588584303856,
0.07200054824352264,
-0.010589228942990303,
0.004468834958970547,
-0.003241538070142269,
-0.00640739593654871,
-0.0008427334250882268,
-0.011801525950431824,
-0.01747874915599823,
0.004028644412755966,
-0.000617596204392612,
-0.016808733344078064,
-0.0008318767650052905,
0.0037437519058585167,
0.010526290163397789,
0.005993635393679142,
-0.00821903720498085,
0.0022628202568739653,
0.01266726665198803,
0.0017351014539599419,
0.02131938748061657,
-0.0009690765291452408,
0.018625646829605103,
-0.0020784789230674505,
0.01195709127932787,
0.005726811476051807,
-0.007583842612802982,
0.005896188784390688,
0.003524214029312134,
0.02805236168205738,
0.007129190489649773,
-0.03150774538516998,
-0.01691018044948578,
0.010371027514338493,
0.009882582351565361,
0.014834918081760406,
0.011279001832008362,
0.00527222640812397,
-0.0017031749011948705,
0.023216163739562035,
-0.001153693301603198,
-0.0055550746619701385,
-0.015063369646668434,
0.01237742230296135,
-0.012220530770719051,
-0.007509456016123295,
-0.001445920206606388,
0.0010966123081743717,
-0.0000016435515135526657,
-0.017681069672107697,
0.01562686637043953,
0.011335223913192749,
0.0012943714391440153,
-0.004025685600936413,
-0.01712973229587078,
-0.010415194556117058,
-0.02063918486237526,
-0.0008936512749642134,
0.019658369943499565,
-0.003075168002396822,
-0.040102437138557434,
-0.005173434037715197,
-0.007111171260476112,
0.004833061248064041,
-0.005615115165710449,
-0.02413071319460869,
-0.0007216660305857658,
0.008911983110010624,
-0.002450193976983428,
-0.02076873742043972,
0.012484056875109673,
-0.006698215380311012,
0.007017257623374462,
0.0054267821833491325,
0.0011231359094381332,
-0.010008474811911583,
0.0002504577860236168,
0.015623615123331547,
-0.012171706184744835,
0.015573156997561455,
-0.000097166484920308,
-0.00233696517534554,
-0.001637738780118525,
0.002418374875560403,
0.0017200710717588663,
-0.0012750281020998955,
0.003139180364087224,
0.00679357722401619,
0.012110897339880466,
-0.015513544902205467,
0.0014456502394750714,
-0.00714527303352952,
-0.010960215702652931,
0.0026726657524704933,
0.0218355730175972,
0.004072256851941347,
0.033490538597106934,
0.010513391345739365,
0.002367182169109583,
0.0011321610072627664,
-0.013850804418325424,
-0.001686482923105359,
0.0051869675517082214,
-0.015943409875035286,
-0.011063634417951107,
-0.006303094327449799,
-0.007845668122172356,
-0.010562440380454063,
0.023978061974048615,
0.009648041799664497,
0.00044341618195176125,
-0.007630678825080395,
-0.015541525557637215,
0.01717001385986805,
-0.006187895312905312,
0.019828666001558304,
0.031079046428203583,
-0.00991728249937296,
0.008646541275084019,
0.0083843432366848,
-0.011959495022892952,
-0.02260647900402546,
0.005503525026142597,
-0.013414021581411362,
0.006041277199983597,
-0.016068939119577408,
0.006764614023268223,
-0.003318562638014555,
0.020580818876624107,
0.0026035760529339314,
0.016171302646398544,
-0.014390047639608383,
0.009494436904788017,
0.015110238455235958,
0.01614951156079769,
-0.00029486091807484627,
0.0014591347426176071,
0.001650160877034068,
0.020304281264543533,
-0.013559163548052311,
0.010740380734205246,
0.012146441265940666,
-0.005192027427256107,
0.010763919912278652,
0.01069884467869997,
0.009379014372825623,
0.011250210925936699,
0.022034334018826485,
0.011090481653809547,
0.01737026870250702,
0.008450498804450035,
0.01145462691783905,
0.0029616979882121086,
-0.01756630465388298,
-0.0018514471594244242,
-0.0161290280520916,
0.005246410146355629,
-0.005906124599277973,
0.003598746843636036,
-0.011823009699583054,
-0.009922640398144722,
0.011534060351550579,
0.007356542162597179,
-0.0027033023070544004,
0.011950531974434853,
-0.0031270065810531378,
-0.012184655293822289,
0.004213289823383093,
-0.010516926646232605,
-0.007346110884100199,
-0.0013537048362195492,
-0.008126620203256607,
0.0009095226414501667,
0.005631797015666962,
0.0054565840400755405,
0.007111959625035524,
0.0008079982362687588,
0.011209899559617043,
0.015244551002979279,
-0.018784768879413605,
0.003425640519708395,
0.007873962633311749,
-0.006598503328859806,
-0.010106207802891731,
-0.007283338345587254,
0.006881153676658869,
0.007349829655140638,
-0.004636324010789394,
-0.001253732480108738,
-0.0014759040204808116,
-0.007785713765770197,
-0.01309660729020834,
-0.013314724899828434,
-0.015352620743215084,
-0.010078354738652706,
-0.00004162127152085304,
-0.000056169694289565086,
0.0031241443939507008,
-0.023938890546560287,
0.0069627827033400536,
0.019832784309983253,
0.006227665115147829,
-0.006029535084962845
] | [
0.3095831573009491,
0.06728440523147583,
0.3008258044719696,
-0.20087087154388428,
-0.010778715834021568,
0.7604897022247314,
0.8722038865089417,
-0.28077009320259094,
-0.21514831483364105,
-0.34704676270484924,
0.0620860755443573,
0.10335937887430191,
0.486609548330307,
-0.07536742836236954,
-0.4425700008869171,
1.2218430042266846,
0.5648959875106812,
0.468797504901886,
-0.24545376002788544,
-0.8398482203483582,
-0.37498557567596436,
-0.46036097407341003,
0.6527990698814392,
0.14377041161060333,
-0.09739867597818375,
0.054216817021369934,
0.8952502608299255,
0.2561783194541931,
0.1104385033249855,
-0.08272910118103027,
-0.2349211573600769,
0.69719398021698,
-0.028953049331903458,
-0.1944853961467743,
0.15263260900974274,
0.05255495011806488,
0.30270901322364807,
-0.21029061079025269,
0.37914803624153137,
-0.43767741322517395,
-0.09912632405757904,
-0.2575741112232208,
-0.030991215258836746,
0.29350027441978455,
-0.3731516897678375,
-0.5170183181762695,
-1.2941676378250122,
0.41064453125,
-0.018603993579745293,
-0.2548115849494934,
0.12906062602996826,
0.1192544549703598,
0.4701329469680786,
0.4449182450771332,
-0.226824551820755,
0.0980549156665802,
-0.4073847532272339,
0.10135333985090256,
0.44704362750053406,
0.005063863005489111,
-0.12610813975334167,
0.11255308985710144,
0.27682530879974365,
-0.03045010007917881,
0.03632437437772751,
0.19390380382537842,
-0.07008766382932663,
0.22722400724887848,
0.06542554497718811,
-0.49380767345428467,
0.020379280671477318,
-0.9220755696296692,
-0.055907126516103745,
0.10163918137550354,
-0.2354254573583603,
-0.08747921139001846,
-0.17498613893985748,
-0.4596203565597534,
0.48520413041114807,
-0.41222745180130005,
0.07252722233533859,
-0.2787591516971588,
0.34757962822914124,
-0.39533084630966187,
0.6709003448486328,
0.35851550102233887,
0.3115957975387573,
-0.18221800029277802,
-0.3344402611255646,
-0.06091339513659477,
0.053469132632017136,
-0.5868154168128967,
0.02090783230960369,
0.596702516078949,
-0.3439284861087799,
0.6335980892181396,
0.25279977917671204,
-0.1454675942659378,
0.29157382249832153,
0.33900076150894165,
0.11402860283851624,
0.27175018191337585,
0.200868159532547,
0.03727984428405762,
-0.6169873476028442,
-0.5116387605667114,
0.06557871401309967,
-0.5262836217880249,
-1.1397874355316162,
0.1521073579788208,
-1.3607897758483887,
0.013363330624997616,
-0.4239612817764282,
-0.11211100220680237,
-0.4810088872909546,
0.09635196626186371,
-0.02076118439435959,
-0.81031733751297,
0.15728534758090973,
0.4519510269165039,
-0.08294659852981567,
0.21551629900932312,
-0.14709843695163727,
0.236042320728302,
-0.06397923082113266,
0.07066499441862106,
0.36210155487060547,
0.5956957340240479,
-0.42718884348869324,
0.15867890417575836,
0.6187573075294495,
0.5656362175941467,
0.028437592089176178,
0.30711057782173157,
0.2201792150735855,
-0.3985818028450012,
0.11067663878202438,
0.4055660665035248,
-0.21908371150493622,
0.1822947859764099,
-0.4434663653373718,
-0.36045852303504944,
-0.22432811558246613,
-0.08029940724372864,
0.009920049458742142,
-0.9891892671585083,
0.058313943445682526,
-0.11863284558057785,
-0.09980425983667374,
0.03844829276204109,
-0.021224981173872948,
0.18403252959251404,
0.34501081705093384,
-0.625645637512207,
-0.0747346356511116,
0.5751412510871887,
-0.09862056374549866,
-0.41675496101379395,
0.3697933852672577,
-0.10023326426744461,
0.532171905040741,
0.48076775670051575,
-0.14801980555057526,
0.16108541190624237,
0.8647558689117432,
0.20290499925613403,
-0.1450958102941513,
0.29725316166877747,
-0.287972629070282,
0.34670671820640564,
-0.5608727335929871,
-0.05310995876789093,
-0.35581400990486145,
-0.6224729418754578,
-0.18069085478782654,
0.134745791554451,
0.3129672706127167,
0.08796828985214233,
-0.12319210916757584,
-0.20323549211025238,
-0.5822044610977173,
0.33953508734703064,
0.09266841411590576,
-0.5021955966949463,
0.0456034280359745,
0.043046824634075165,
0.004279996734112501,
0.20532114803791046,
0.36547791957855225,
0.16208946704864502,
-0.027341613546013832,
-0.8389820456504822,
1.0137412548065186,
-0.2132386416196823,
1.0057698488235474,
-0.2203192114830017,
-0.12475225329399109,
1.1376522779464722,
-0.11598038673400879,
-0.23950792849063873,
0.03200966492295265,
-0.34359151124954224,
0.355162650346756,
0.026942845433950424,
-0.35422635078430176,
0.14720742404460907,
-0.30190855264663696,
-0.35430067777633667,
-0.2836969494819641,
0.13685281574726105,
0.20891106128692627,
-0.32161596417427063,
-0.4365106523036957,
0.08708846569061279,
-0.10512954741716385,
0.04879379644989967,
0.07501290738582611,
0.11629796028137207,
0.2994721233844757,
-0.10446394234895706,
0.48432451486587524,
-0.4095953106880188,
0.3878239691257477,
0.36821281909942627,
-0.17988066375255585,
0.25381383299827576,
0.5608856081962585,
0.12074370682239532,
0.538260281085968,
-0.7221590876579285,
0.47290000319480896,
0.49918487668037415,
0.24262729287147522,
-0.32617834210395813,
-0.15055733919143677,
0.07983900606632233,
-0.5344818234443665,
-0.021680550649762154,
-0.22619254887104034,
-0.24278393387794495,
-0.025109773501753807,
-0.07858031988143921,
-0.3343870937824249,
0.14415264129638672,
0.01226511038839817,
-0.3956204354763031,
-0.8124707341194153,
0.46681657433509827,
-0.5673143863677979,
0.07891738414764404,
0.107380710542202,
0.2212885022163391,
-0.2979733943939209,
-0.15880157053470612,
0.30565017461776733,
0.08983103185892105,
0.3956248462200165,
-0.15788568556308746,
-0.17849338054656982,
-0.26492077112197876,
-0.016456851735711098,
0.36753129959106445,
0.35413485765457153,
-0.0620826818048954,
0.32754915952682495,
-0.3449738323688507,
-0.8353378176689148,
-0.7705380916595459,
0.6334422826766968,
0.6057322025299072,
0.0854952409863472,
0.27744483947753906,
-0.3864137530326843,
0.2798772156238556,
-0.1974179893732071,
-0.9160221219062805,
-0.31753891706466675,
0.7734821438789368,
-0.7609900832176208,
-0.48098623752593994,
-0.10676474124193192,
0.3822080194950104,
0.6900346875190735,
-0.3109864294528961,
-0.016330990940332413,
0.0877578854560852,
0.36775362491607666,
0.05251670256257057,
-0.38643449544906616,
0.14081062376499176,
0.20863167941570282,
0.36213991045951843,
0.008678410202264786,
-0.7169443964958191,
0.4835996627807617,
0.6486431360244751,
0.22024226188659668,
0.5335089564323425,
0.8054818511009216,
-0.06488359719514847,
-0.22393982112407684,
0.2832598090171814,
0.00028729834593832493,
-0.011326143518090248,
-0.14845451712608337,
-0.3507983088493347,
-0.37393447756767273,
-0.048197075724601746,
-5.9252166748046875,
0.1407262235879898,
-0.37504929304122925,
-0.15786024928092957,
0.19384343922138214,
0.2535898685455322,
0.8903656005859375,
-0.3163832128047943,
-0.22961890697479248,
0.3563808798789978,
0.47346433997154236,
0.18643948435783386,
0.24525634944438934,
0.4871116578578949,
0.4450930953025818,
0.3190917670726776,
0.2911641299724579,
0.07890491187572479,
0.5092300772666931,
-0.19122914969921112,
0.32869279384613037,
-0.23003695905208588,
0.09799197316169739,
0.3446228802204132,
0.5118829607963562,
0.6586982607841492,
-0.616521418094635,
0.21646945178508759,
-0.7214356660842896,
-0.4635913670063019,
0.2547750473022461,
-0.2879405617713928,
-0.35268691182136536,
0.0911608338356018,
0.49363797903060913,
0.14631439745426178,
0.5109242796897888,
0.43157052993774414,
0.2971460819244385,
-0.1960577517747879,
0.2244451642036438,
0.8168230652809143,
-0.41958338022232056,
-0.17095644772052765,
-0.1824701875448227,
-0.03154518082737923,
-0.20786629617214203,
0.10942529886960983,
-0.45770204067230225,
0.8140105605125427,
-0.2530028223991394,
0.09790299832820892,
0.2175002098083496,
0.7158915996551514,
0.03190925717353821,
-0.2270471751689911,
-0.32145029306411743,
0.5800685286521912,
-0.3749214708805084,
0.4051385223865509,
-0.10052713751792908,
0.06441711634397507,
0.027608973905444145,
-1.1203296184539795,
-0.48003947734832764,
0.17756056785583496,
-0.8463696241378784,
-0.3941447138786316,
0.25346893072128296,
-0.08544792979955673,
-0.36541271209716797,
-0.5866036415100098,
0.46646881103515625,
-0.650932788848877,
0.1412331610918045,
-0.6400109529495239,
-0.10772787779569626,
0.05417283996939659,
0.0168180912733078,
0.13080382347106934,
0.20356182754039764,
-0.2512739300727844,
0.3143387734889984,
-0.27936267852783203,
0.3862040340900421,
0.03828302025794983,
-0.3280123770236969,
-0.18826483190059662,
0.17241446673870087,
0.13758577406406403,
0.0017082212725654244,
-0.34521394968032837,
0.1610506922006607,
0.1884799748659134,
-0.0790862888097763,
0.9854182004928589,
-0.08709641546010971,
-0.1541898399591446,
0.013003423810005188,
0.032738808542490005,
1.1730562448501587,
-0.0007021425990387797,
-0.5368970632553101,
-0.7563024163246155,
-0.08967098593711853,
-0.013117138296365738,
-0.37391549348831177,
0.21478046476840973,
0.47280529141426086,
-0.5823326110839844,
-0.05670695751905441,
-0.31457892060279846,
0.08763090521097183,
-0.5442754030227661,
0.6928889155387878,
-0.45609134435653687,
-0.5391691327095032,
0.3440396189689636,
0.0792207196354866,
0.23615388572216034,
0.6069932579994202,
-0.156858891248703,
-0.12586966156959534,
-0.14169323444366455,
-0.15150049328804016,
-0.33159464597702026,
0.07847876846790314,
0.2790590524673462,
-0.5873169302940369,
0.6071470975875854,
0.0444687195122242,
0.24655179679393768,
-0.10878768563270569,
-0.18018680810928345,
0.09988690167665482,
0.030286232009530067,
-0.29342445731163025,
-0.04033837467432022,
0.08762257546186447,
-0.22865088284015656,
0.2374342828989029,
0.08557285368442535,
-0.1315276324748993,
0.5241072177886963,
0.08962396532297134,
-0.2417527586221695,
-0.040206167846918106,
-0.08759213984012604,
-0.19548670947551727,
-0.2536134719848633,
-0.02017315849661827,
0.09977446496486664,
0.3396577537059784,
-0.32894033193588257,
-0.33319681882858276,
-0.22672264277935028,
0.3367750644683838,
0.30033478140830994,
-0.06767743080854416,
-0.47836992144584656,
0.24253927171230316,
-0.26386651396751404,
-1.1157349348068237,
0.2767673432826996,
0.39359250664711,
-0.7750542759895325,
-0.3369293808937073,
-0.3559524714946747,
-0.15361234545707703,
0.5359477400779724,
-0.04917646571993828,
-0.1885933130979538,
0.026618022471666336,
0.515819251537323,
0.3123522102832794,
-0.13034586608409882,
-0.24784208834171295,
0.3734016716480255,
-0.0068393610417842865,
0.260811448097229,
-0.01237491238862276,
-0.02876920811831951,
-0.552376925945282,
0.29361623525619507,
0.7244966626167297,
0.7974988222122192,
-0.11924956738948822,
-0.3152758777141571,
-0.29983022809028625,
-0.24165402352809906,
0.43917903304100037,
-0.33220550417900085,
0.6340281963348389,
0.11517904698848724,
-0.10034036636352539,
-0.4592147469520569,
0.2571685314178467,
-0.04481847584247589,
-0.14887773990631104,
0.10806891322135925,
0.08590725064277649,
0.49552083015441895,
-0.6030306220054626,
0.15630310773849487,
0.6520774960517883,
-0.4538925886154175,
0.16151462495326996,
-0.04767856374382973,
-0.5101302862167358,
-0.01950714737176895,
-0.5241235494613647,
-0.4017718732357025,
-0.5684115290641785,
0.26605382561683655,
-0.7846736311912537,
0.10724671185016632,
0.18242955207824707,
-0.5771410465240479,
-0.3201252818107605,
0.43251875042915344,
-0.06287894397974014,
-0.3370550572872162,
-0.620879590511322,
-0.2118198275566101,
-0.4638448655605316,
-0.14335580170154572,
0.4481249749660492,
-1.2666338682174683,
-0.34757715463638306,
0.02095610648393631,
0.06875307112932205,
0.08551550656557083,
0.4778347909450531,
-0.06658551841974258,
-0.5293843150138855,
-0.25490936636924744,
-0.2766789197921753,
0.12625029683113098,
-0.02572156861424446,
0.2643393278121948,
0.31548815965652466,
0.5800820589065552,
0.3131307065486908,
-0.989615797996521,
0.5214242935180664,
0.2560567557811737,
0.6657302379608154,
-0.5190079808235168,
-0.26302239298820496,
0.528346061706543,
0.21890103816986084,
-0.24233926832675934,
0.21364018321037292,
-0.31915995478630066,
0.5760669112205505,
0.10194628685712814,
-0.43666136264801025,
-0.23770374059677124,
0.4752831757068634,
0.5142682194709778,
-0.42237579822540283,
-0.671775221824646,
-0.014208532869815826,
-0.3477553427219391,
0.14031098783016205,
-0.04949868097901344,
-0.11871837824583054,
0.01397058367729187,
0.03540370240807533,
-0.42095306515693665,
-0.15566740930080414,
0.23715907335281372,
0.20929542183876038,
-0.12134360522031784,
0.1988300383090973,
0.012953493744134903,
-0.3092643618583679,
0.09162413328886032,
0.05598641559481621,
0.06584415584802628,
-0.4121119976043701,
-0.3941091001033783,
0.04391143471002579,
-0.23577478528022766,
-0.18709948658943176,
-0.560491144657135,
0.25356540083885193,
0.4396999478340149,
-0.6135109066963196,
0.24309398233890533,
0.11157948523759842,
-0.3684314787387848,
-0.7308622598648071,
0.3139602243900299,
0.2333863377571106,
0.28873375058174133,
0.2682257890701294,
0.18009105324745178,
0.09527310729026794,
-0.32637152075767517,
-0.21230021119117737,
0.6561717391014099,
0.3482513129711151,
-0.09281621873378754,
0.3552679419517517,
0.3054770827293396,
0.29912734031677246,
-0.5134334564208984,
0.09858185052871704,
0.0022187409922480583,
0.37506791949272156,
0.02033182792365551,
0.31034785509109497,
0.8916597962379456,
-0.4008629620075226,
-0.3186311423778534,
-0.17250290513038635,
0.06831520050764084,
0.16887597739696503,
0.12871338427066803,
0.25315970182418823,
0.33118683099746704,
0.8620296120643616,
0.095033198595047,
-0.20636628568172455,
0.9691585302352905,
0.1133100613951683,
0.399968683719635,
0.38110098242759705,
-0.12643404304981232,
0.3530803322792053,
1.1182656288146973,
-0.11390689015388489,
0.24328161776065826,
-0.004860586021095514,
0.34771737456321716,
-0.037602368742227554,
-0.07000818848609924,
-0.14819961786270142,
0.17346243560314178,
0.3961147367954254,
0.316053181886673,
-0.12394779920578003,
-0.16761304438114166,
0.2507127821445465,
0.48658812046051025,
0.07777554541826248,
-0.26415368914604187,
0.2973960041999817,
0.09344946593046188,
0.06149090826511383,
-0.14464114606380463,
-0.304355651140213,
0.07051954418420792,
-0.5348670482635498,
0.39268606901168823,
-0.05345842242240906,
-0.3297542929649353,
-0.761272132396698,
0.3139132857322693,
0.09642429649829865,
-0.3723873794078827,
-0.20933468639850616,
0.06232103332877159,
-0.36436063051223755,
-0.12268951535224915,
0.23815636336803436,
0.021010760217905045,
-0.18527761101722717,
-0.24309581518173218,
-0.09804318845272064,
-0.1950097531080246,
-0.21252627670764923,
-0.025164242833852768,
-0.11466776579618454,
-0.9445409774780273,
0.446093887090683,
-0.3643886148929596,
0.06353609263896942,
0.5591117143630981,
-0.32702845335006714,
-0.038236986845731735,
0.023035744205117226,
-0.16967199742794037,
-0.11008103936910629,
-0.1231585294008255,
-0.20397421717643738,
-0.34764400124549866,
0.17663533985614777,
0.19187068939208984,
0.22383710741996765,
-0.4663768708705902,
-0.20571206510066986,
-0.0828094482421875,
-0.1444280445575714,
-0.1542784422636032,
-0.4281338155269623,
0.3510723114013672,
0.7972145676612854,
-0.1368713527917862,
-0.3486594259738922,
0.22367790341377258,
-0.05299380421638489,
0.26423898339271545,
-0.21704040467739105,
-0.14430417120456696,
-0.4332437515258789,
-0.2996782064437866,
-0.43653422594070435,
0.09075844287872314,
0.47868818044662476,
0.18439534306526184,
-0.36284253001213074,
-0.011744230054318905,
0.17217107117176056,
0.2224944829940796,
0.7100091576576233,
-0.23860150575637817,
-0.1814715564250946,
-0.39223751425743103,
0.0009275402990169823,
-0.7456356287002563,
0.6705927848815918,
-0.08082965761423111,
-0.014004847966134548,
-0.26300743222236633,
0.0722690150141716,
0.2790205776691437,
-0.4153653383255005,
0.752625584602356,
-0.40496373176574707,
-0.0700199156999588,
-0.3583725392818451,
0.2648695409297943,
-0.6548849940299988,
0.7140331268310547,
0.514340341091156,
0.21322230994701385,
0.35769355297088623,
-0.202046737074852,
-0.4227447509765625,
-0.7467736005783081,
0.33215293288230896,
0.5274237394332886,
0.2507585287094116,
0.626974880695343,
0.026326660066843033,
-0.28240764141082764,
-0.4639195203781128,
-0.19475604593753815,
-0.4896317422389984,
-0.414614737033844,
0.18911395967006683,
-0.35996031761169434,
-0.24546661972999573,
-0.17695878446102142,
-0.2696872055530548,
-0.4582345187664032,
0.23384632170200348,
-0.26844650506973267
] |
ContextSeveral novel risk factors for atherosclerosis have recently been proposed, but few comparative data exist to guide clinical use of these emerging biomarkers. ObjectiveTo compare the predictive value of 11 lipid and nonlipid biomarkers as risk factors for development of symptomatic peripheral arterial disease (PAD).Design, Setting, and ParticipantsNested case-control study using plasma samples collected at baseline from a prospective cohort of 14 916 initially healthy US male physicians aged 40 to 84 years, of whom 140 subsequently developed symptomatic PAD (cases); 140 age- and smoking status–matched men who remained free of vascular disease during an average 9-year follow-up period were randomly selected as controls. Main Outcome MeasureIncident PAD, as determined by baseline total cholesterol, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), total cholesterol–HDL-C ratio, triglycerides, homocysteine, C-reactive protein (CRP), lipoprotein(a), fibrinogen, and apolipoproteins (apo) A-I and B-100.ResultsIn univariate analyses, plasma levels of total cholesterol (P<.001), LDL-C (P = .001), triglycerides (P = .001), apo B-100 (P = .001), fibrinogen (P = .02), CRP (P = .006), and the total cholesterol–HDL-C ratio (P<.001) were all significantly higher at baseline among men who subsequently developed PAD compared with those who did not, while levels of HDL-C (P = .009) and apo A-I (P = .05) were lower. Nonsignificant baseline elevations of lipoprotein(a) (P = .40) and homocysteine (P = .90) were observed. In multivariable analyses, the total cholesterol–HDL-C ratio was the strongest lipid predictor of risk (relative risk [RR] for those in the highest vs lowest quartile, 3.9; 95% confidence interval [CI], 1.7-8.6), while CRP was the strongest nonlipid predictor (RR for the highest vs lowest quartile, 2.8; 95% CI, 1.3-5.9). In assessing joint effects, addition of CRP to standard lipid screening significantly improved risk prediction models based on lipid screening alone (P<.001).ConclusionsOf 11 atherothrombotic biomarkers assessed at baseline, the total cholesterol–HDL-C ratio and CRP were the strongest independent predictors of development of peripheral arterial disease. C-reactive protein provided additive prognostic information over standard lipid measures. | [
-0.012262113392353058,
0.030762048438191414,
-0.01113878469914198,
0.01627729833126068,
0.04045609012246132,
0.006679967045783997,
0.010673889890313148,
-0.0026394017040729523,
-0.0031051014084368944,
-0.011217979714274406,
0.0034517133608460426,
0.0076488470658659935,
-0.009442631155252457,
0.02046278864145279,
0.010612019337713718,
0.002991268876940012,
-0.028795935213565826,
0.0006977664306759834,
0.008511938154697418,
0.003949389792978764,
-0.011475526727735996,
-0.001487156841903925,
0.010384972207248211,
0.01786082796752453,
-0.005718202330172062,
-0.018798965960741043,
0.04482372850179672,
-0.004683021921664476,
-0.02770339325070381,
-0.005217905156314373,
0.004701585974544287,
0.004301999695599079,
-0.023043271154165268,
0.020034100860357285,
-0.0004550870507955551,
0.004492809064686298,
-0.0023668850772082806,
-0.006643187254667282,
-0.027870751917362213,
-0.006560608744621277,
-0.014742977917194366,
-0.007870083674788475,
-0.0019682340789586306,
0.009774298407137394,
-0.018767479807138443,
0.0006858545821160078,
-0.0031384406611323357,
0.016606345772743225,
-0.006125814747065306,
0.013979915529489517,
-0.006150385830551386,
0.00015709945000708103,
-0.022677890956401825,
-0.02673480287194252,
-0.007068237289786339,
-0.0072833457961678505,
0.0201216172426939,
-0.007844556123018265,
-0.031407229602336884,
0.03170834481716156,
-0.019400641322135925,
-0.030939504504203796,
0.0032950914464890957,
-0.003196608042344451,
-0.018274005502462387,
-0.06636594235897064,
0.013083131983876228,
0.02183775044977665,
-0.0035715559497475624,
-0.03594974800944328,
-0.0018250741995871067,
0.005878048483282328,
0.019980061799287796,
0.017648689448833466,
-0.009259813465178013,
-0.007298791781067848,
0.009552597999572754,
-0.007053629495203495,
-0.0002927766181528568,
-0.03205535560846329,
-0.031718432903289795,
0.003500463906675577,
-0.020475970581173897,
0.027431491762399673,
-0.005334549583494663,
0.02082209661602974,
-0.01902715116739273,
0.0016699070110917091,
0.0039490582421422005,
-0.011688764207065105,
-0.012571354396641254,
-0.00863644015043974,
-0.027637215331196785,
-0.018358048051595688,
-0.03317514806985855,
-0.04679352045059204,
0.005980742629617453,
0.028030594810843468,
0.033466365188360214,
0.010964391753077507,
-0.030550643801689148,
-0.03226054832339287,
0.023541323840618134,
-0.00732079055160284,
-0.009456549771130085,
0.007215950638055801,
-0.005001855082809925,
-0.007101728115230799,
0.0028211649041622877,
0.01121455430984497,
-0.009329507127404213,
0.054239049553871155,
0.015274597331881523,
-0.0029961802065372467,
0.0008990420028567314,
0.012638353742659092,
0.009961863979697227,
0.010863834992051125,
0.009867987595498562,
0.004558292217552662,
0.01171177439391613,
-0.014905817806720734,
-0.013904893770813942,
0.03470085188746452,
-0.0024244398809969425,
-0.007974501699209213,
0.021852847188711166,
0.016480565071105957,
0.018160587176680565,
0.003954564221203327,
-0.015475867316126823,
-0.014202892780303955,
0.003104530042037368,
0.02381586655974388,
0.011553592048585415,
0.005872698500752449,
0.004508125130087137,
-0.012709507718682289,
-0.0121820829808712,
-0.003003778401762247,
0.00544357905164361,
0.008533124811947346,
0.0006642388179898262,
0.009337863884866238,
-0.006345544476062059,
-0.003959077876061201,
-0.01941715180873871,
0.010235607624053955,
0.024974491447210312,
-0.0034372410736978054,
0.014892123639583588,
0.008188016712665558,
0.00349765969440341,
-0.034344010055065155,
-0.008021561428904533,
0.01946287602186203,
-0.007822303101420403,
0.010055401362478733,
-0.010807542130351067,
0.008142322301864624,
-0.015645397827029228,
0.010171771049499512,
0.020997220650315285,
0.011258341372013092,
0.003839357988908887,
0.0026803198270499706,
0.023544058203697205,
-0.009281236678361893,
0.005353434942662716,
0.004968266002833843,
-0.003983872011303902,
0.013978025875985622,
-0.007895197719335556,
0.011176030151546001,
-0.01723162829875946,
-0.008321227505803108,
0.0037655578926205635,
0.011836042627692223,
-0.019437449052929878,
0.06605440378189087,
-0.006677380297333002,
0.0009842149447649717,
0.008440692909061909,
-0.04238998144865036,
0.010998040437698364,
-0.006095618009567261,
-0.005584266968071461,
-0.0059853303246200085,
-0.0003554420545697212,
-0.006573886144906282,
0.015791207551956177,
0.010444002225995064,
0.017068134620785713,
0.01259260531514883,
-0.02301841974258423,
0.0036424254067242146,
-0.03378098085522652,
-0.0054831975139677525,
0.0074189454317092896,
0.00872889906167984,
0.028507908806204796,
-0.011722827330231667,
0.019261479377746582,
-0.008831974118947983,
0.013282306492328644,
0.007464583031833172,
0.0033131081145256758,
-0.035374484956264496,
-0.018175926059484482,
0.011546378955245018,
0.015704436227679253,
-0.014382562600076199,
0.010197358205914497,
-0.011542189866304398,
-0.003044862300157547,
-0.010302725248038769,
-0.0178561769425869,
0.01831846311688423,
-0.0014062165282666683,
-0.012470769695937634,
-0.0033263321965932846,
-0.008692795410752296,
-0.00986504927277565,
0.011075098067522049,
0.022232536226511,
-0.008685238659381866,
-0.003039756091311574,
0.007100842427462339,
0.011513754725456238,
-0.0032922369427978992,
-0.00584410410374403,
-0.0007995287887752056,
-0.012745959684252739,
-0.005233317613601685,
0.008486397564411163,
-0.027840886265039444,
0.013454459607601166,
-0.0020020012743771076,
0.012628572061657906,
-0.014857123605906963,
-0.0045785848051309586,
-0.02900494635105133,
0.0152661157771945,
-0.012824038043618202,
0.026268750429153442,
-0.01340931560844183,
-0.011398839764297009,
0.006486956495791674,
-0.016649700701236725,
-0.00794869102537632,
0.008236768655478954,
-0.010008742101490498,
-0.0023430068977177143,
-0.0010680025443434715,
-0.014073521830141544,
-0.006389719434082508,
0.002673302311450243,
-0.031149007380008698,
0.027188457548618317,
-0.014533232897520065,
0.018895654007792473,
0.010388458147644997,
0.0032475823536515236,
0.0025805654004216194,
-0.030630851164460182,
-0.0072483159601688385,
0.015969697386026382,
0.030109871178865433,
-0.014424080029129982,
-0.04353165999054909,
0.012503648176789284,
-0.005290316417813301,
-0.004180291201919317,
-0.08121534436941147,
-0.0066161067225039005,
0.008286272175610065,
0.019711757078766823,
0.003364040981978178,
0.006738272961229086,
0.02302154153585434,
0.01876572147011757,
-0.017253601923584938,
-0.021035566926002502,
0.005223721265792847,
0.020387671887874603,
-0.0069918339140713215,
0.032632872462272644,
-0.017323121428489685,
-0.004939504899084568,
0.0011719129979610443,
0.006525043398141861,
-0.003621733980253339,
-0.024679921567440033,
0.016621554270386696,
0.014648722484707832,
-0.003979205619543791,
-0.005048702005296946,
0.0058825998567044735,
0.011859268881380558,
-0.026611726731061935,
-0.007563677616417408,
-0.013153672218322754,
0.013767817988991737,
-0.014238033443689346,
-0.038270674645900726,
0.014653567224740982,
-0.006299566011875868,
-0.01628969796001911,
-0.02464975230395794,
-0.015410395339131355,
-0.0027697349432855844,
0.016985435038805008,
0.019287431612610817,
-0.00382376741617918,
0.017125597223639488,
-0.02129332348704338,
0.002557038562372327,
0.00289898831397295,
0.005961744114756584,
0.002599783707410097,
0.014530199579894543,
0.015753500163555145,
-0.026749467477202415,
0.002237643813714385,
-0.0008768814150243998,
-0.0019384156912565231,
0.015428573824465275,
-0.019603081047534943,
-0.015259907580912113,
-0.002694952767342329,
0.0034401919692754745,
-0.006934450939297676,
-0.01855197548866272,
-0.00021612877026200294,
-0.013526823371648788,
0.018829060718417168,
0.02762317843735218,
-0.02212594263255596,
0.018995683640241623,
0.0038424807135015726,
0.013979167677462101,
-0.00520881125703454,
0.011011393740773201,
0.036233000457286835,
0.01106722466647625,
-0.011009758338332176,
-0.005886743776500225,
0.005100428592413664,
-0.012175222858786583,
-0.02159161865711212,
-0.004398440010845661,
-0.011480621062219143,
0.0038793461862951517,
-0.00002173543907701969,
0.0016226023435592651,
0.00587883498519659,
0.017008882015943527,
0.0003844104357995093,
0.016876855865120888,
0.01771196722984314,
0.04212721437215805,
0.007925224490463734,
-0.0009244260145351291,
-0.0337870791554451,
0.03524724021553993,
0.03175253048539162,
0.010962544940412045,
0.024236205965280533,
-0.01139916479587555,
-0.007021874655038118,
-0.025030918419361115,
-0.001360626658424735,
0.008491846732795238,
-0.015463311225175858,
0.00011610379442572594,
-0.015037515200674534,
-0.01877295784652233,
-0.0032695536501705647,
0.002263975329697132,
-0.000957548909354955,
-0.012720786966383457,
-0.007756256964057684,
-0.007895020768046379,
-0.029957348480820656,
0.0020798570476472378,
-0.001080868998542428,
0.031145351007580757,
0.0017247529467567801,
0.010720662772655487,
-0.006446709856390953,
0.020313765853643417,
0.0718175619840622,
-0.013237662613391876,
0.0038642105646431446,
-0.0242433100938797,
0.004609264433383942,
-0.02766204997897148,
-0.03364234417676926,
0.007053708657622337,
0.001547293271869421,
0.003779484424740076,
0.014036796055734158,
-0.002128017134964466,
0.012022487819194794,
-0.005968277342617512,
-0.041590891778469086,
-0.015602266415953636,
0.0006530142854899168,
0.008023211732506752,
0.01389105711132288,
0.01410608272999525,
-0.013745466247200966,
-0.01644490472972393,
-0.006358445156365633,
-0.009569767862558365,
0.03342357277870178,
0.007791244890540838,
0.006754799280315638,
-0.013233857229351997,
-0.024474281817674637,
0.007902603596448898,
-0.007058797869831324,
-0.023978829383850098,
-0.008792083710432053,
0.024897802621126175,
0.0014413974713534117,
0.0051171863451600075,
-0.010217258706688881,
0.003201671177521348,
0.018393946811556816,
-0.006315858103334904,
-0.020452328026294708,
-0.004081648774445057,
0.002529177814722061,
-0.00883837603032589,
-0.016409682109951973,
0.029435817152261734,
0.0026552355848252773,
-0.01430591195821762,
-0.006602431647479534,
0.025639284402132034,
0.005306652747094631,
0.013704204931855202,
0.023229554295539856,
0.0007147197611629963,
-0.022748462855815887,
-0.006129615008831024,
-0.00030623143538832664,
0.002004735404625535,
-0.018591687083244324,
-0.023671183735132217,
-0.005125148221850395,
-0.00586578156799078,
-0.008806232362985611,
-0.002985921688377857,
-0.021842284128069878,
-0.016566209495067596,
-0.005413004197180271,
-0.00802707951515913,
-0.04243416711688042,
-0.013295847922563553,
0.008723994717001915,
0.013540894724428654,
0.00888215284794569,
-0.006613121367990971,
-0.035942383110523224,
-0.0071980711072683334,
0.002659040968865156,
0.00852842628955841,
0.00864634569734335,
-0.009507655166089535,
-0.019306868314743042,
0.03755183517932892,
-0.0067888544872403145,
-0.013484134338796139,
0.006231016479432583,
0.016352539882063866,
-0.03241945058107376,
-0.07516279071569443,
0.0013866433873772621,
-0.004797179717570543,
-0.013752797618508339,
-0.041296862065792084,
0.03084588423371315,
-0.016467180103063583,
0.023928115144371986,
-0.0012515198905020952,
0.009368661791086197,
-0.01598149910569191,
-0.007446083705872297,
0.02157742902636528,
-0.0046915775164961815,
0.017401931807398796,
0.018272291868925095,
-0.00576509116217494,
0.0031889351084828377,
0.017571717500686646,
-0.002150257583707571,
0.040925078094005585,
0.001636737259104848,
-0.03165184706449509,
-0.010847413912415504,
-0.010114666074514389,
-0.08068372309207916,
-0.02270936593413353,
-0.010535810142755508,
0.0032373410649597645,
-0.021308479830622673,
-0.03419703245162964,
0.03504618629813194,
-0.0020928452722728252,
-0.004511124920099974,
-0.01319508720189333,
-0.006543764844536781,
0.003480037674307823,
0.01758684404194355,
-0.0020296727307140827,
0.001259370008483529,
-0.007274585776031017,
0.016902800649404526,
-0.010861329734325409,
-0.01546812616288662,
0.014914357103407383,
0.013242505490779877,
0.01294341403990984,
-0.0043291859328746796,
0.015328235924243927,
-0.015266794711351395,
-0.04012996330857277,
-0.000528028467670083,
0.017443183809518814,
0.03282828629016876,
-0.02321683242917061,
-0.026740454137325287,
-0.0025245207361876965,
-0.013832209631800652,
0.03117026947438717,
-0.022452566772699356,
-0.01600501872599125,
0.006677978206425905,
0.0019517011241987348,
-0.01489957980811596,
-0.006730552762746811,
-0.002413662848994136,
-0.0013159029185771942,
-0.030795563012361526,
0.010219604708254337,
0.0022530159913003445,
-0.001424688147380948,
0.009965183213353157,
-0.014759009703993797,
0.019148578867316246,
0.015168103389441967,
0.010411517694592476,
-0.02117167040705681,
0.010146945714950562,
0.011867842637002468,
-0.013256384059786797,
0.008991571143269539,
-0.01386865135282278,
-0.0007385334465652704,
0.013050418347120285,
0.01563653163611889,
-0.005297313444316387,
0.019534122198820114,
-0.008112049661576748,
0.07119043916463852,
-0.0240154005587101,
-0.009231478907167912,
-0.0021250273566693068,
-0.012597122229635715,
0.002235541120171547,
-0.06033955514431,
-0.02326599508523941,
0.0005581928417086601,
-0.012558038346469402,
-0.00795760191977024,
-0.021290522068738937,
0.05804095417261124,
0.007564765401184559,
-0.007566636428236961,
0.007571324706077576,
0.00443426426500082,
-0.013607978820800781,
-0.004981597885489464,
0.019351182505488396,
0.0254663173109293,
0.019626004621386528,
-0.053689174354076385,
-0.0180366151034832,
-0.002691947855055332,
-0.011826222762465477,
-0.015415290370583534,
-0.02537967637181282,
0.0030151186510920525,
-0.002698116935789585,
0.01732002943754196,
-0.028364654630422592,
0.011653605848550797,
0.01746267080307007,
0.014679970219731331,
-0.0017731229308992624,
0.016428107395768166,
0.010370241478085518,
-0.011832342483103275,
-0.01479295827448368,
0.025452373549342155,
-0.0034494097344577312,
-0.0046591502614319324,
-0.01679220050573349,
0.01672065258026123,
-0.021641403436660767,
0.010759088210761547,
-0.008109081536531448,
0.02468607947230339,
0.006402287632226944,
0.02405059151351452,
0.0006670604925602674,
0.037996985018253326,
0.002190785016864538,
-0.007613284979015589,
0.028397468850016594,
0.010068478062748909,
0.019672205671668053,
-0.0028019030578434467,
-0.01371094025671482,
0.010659173130989075,
-0.003190278774127364,
-0.004782754462212324,
-0.020263878628611565,
-0.011159399524331093,
-0.027812253683805466,
-0.0017969247419387102,
-0.011332959868013859,
-0.02332719787955284,
0.00642734207212925,
0.05527040362358093,
0.010440418496727943,
0.006777473725378513,
0.022600652649998665,
0.029960718005895615,
0.014960825443267822,
0.020812079310417175,
-0.013408876024186611,
0.012550245970487595,
-0.0044431621208786964,
-0.002163176191970706,
0.006669799797236919,
0.039435699582099915,
-0.018632235005497932,
0.006002332549542189,
0.006406788714230061,
0.0008723041974008083,
0.0064218249171972275,
-0.008374571800231934,
0.00603742990642786,
-0.014448408037424088,
0.008845079690217972,
-0.001351797953248024,
0.009272160939872265,
0.008522219955921173,
0.035592056810855865,
-0.016922950744628906,
0.009253893978893757,
-0.0067574642598629,
0.015171057544648647,
-0.004003406036645174,
0.0012171403504908085,
0.0103651974350214,
0.010865263640880585,
0.016971062868833542,
0.016544975340366364,
0.011303793638944626,
-0.0026735805440694094,
-0.00920695811510086,
-0.007370310835540295,
-0.029386678710579872,
-0.020023496821522713,
0.030272597447037697,
0.021122047677636147,
0.01784072071313858,
0.022450366988778114,
-0.0017931900219991803,
0.0036702982615679502,
0.024932466447353363,
-0.02071266807615757,
-0.008250880986452103,
-0.020094694569706917,
0.0010589008452370763,
0.010511357337236404,
0.00451990682631731,
-0.004707871470600367,
-0.006901548244059086,
-0.02406245842576027,
0.02647400088608265,
-0.002224230905994773,
0.01846320368349552,
-0.0005871355533599854,
-0.007500680163502693,
-0.012638282030820847,
-0.0034550451673567295,
-0.01746607944369316,
-0.0166008323431015,
-0.011344924569129944,
-0.004170660860836506,
-0.005913356319069862,
0.011112067848443985,
0.00401912909001112,
-0.0022430242970585823,
-0.0030236924067139626,
0.009233684279024601,
0.008511497639119625,
-0.009592050686478615,
0.05271878466010094,
0.008790941908955574,
-0.013374004513025284,
0.004623064771294594,
0.024523796513676643,
-0.0025198939256370068,
-0.0009004035964608192,
-0.007771891541779041,
0.009978272020816803,
0.015367955900728703,
0.023734422400593758,
-0.028147626668214798,
-0.007031254470348358,
-0.004184200428426266,
0.001566501334309578,
-0.01227964274585247,
-0.0016315614338964224,
0.01610795222222805,
-0.014585278928279877,
-0.010547805577516556,
-0.0031799692660570145,
-0.003964824602007866,
0.005186119116842747,
0.008949730545282364,
0.005425460636615753,
-0.019933298230171204,
0.00680065480992198,
-0.020723726600408554,
-0.010912804864346981,
-0.009864263236522675,
-0.0017734551802277565,
-0.012956912629306316,
0.013160324655473232,
0.02988838031888008,
-0.02213962748646736,
-0.006377880461513996,
-0.02552296221256256,
-0.000047700596041977406,
-0.007749402895569801,
-0.0007965542608872056,
-0.011659706011414528,
0.011448714882135391,
-0.008874360471963882,
-0.018842509016394615,
-0.019082708284258842,
-0.007779798470437527,
0.0010269274935126305,
-0.013817684724926949,
-0.004966653883457184,
-0.013928054831922054,
-0.0068350969813764095,
-0.0175861194729805,
-0.01713666506111622,
0.011379498057067394,
0.0016988818533718586
] | [
-0.13475824892520905,
0.08967343717813492,
0.6462609767913818,
0.16858209669589996,
0.07522168010473251,
0.47505760192871094,
0.12708395719528198,
-0.2607033848762512,
-0.06648500263690948,
-0.4101337194442749,
0.27800172567367554,
0.48776477575302124,
0.263136088848114,
-0.04170970246195793,
0.24908943474292755,
0.9110354781150818,
0.28370630741119385,
0.11324352771043777,
0.038729116320610046,
-0.6322851181030273,
-0.2457645833492279,
-0.49212780594825745,
0.25174257159233093,
-0.36221960186958313,
0.16016525030136108,
0.41397929191589355,
0.0764540582895279,
-0.36716029047966003,
-0.3102147579193115,
-0.006931580603122711,
-0.233388289809227,
0.8358877897262573,
-0.065996453166008,
0.2739660143852234,
0.032994434237480164,
0.4304381310939789,
0.25687891244888306,
-0.08201178908348083,
0.3084701895713806,
-0.49234455823898315,
-0.40464502573013306,
-0.29522013664245605,
0.06901005655527115,
0.09838630259037018,
-0.28679949045181274,
-0.5031418204307556,
-1.232174038887024,
-0.00290882121771574,
-0.37760111689567566,
0.30461129546165466,
-0.1216973215341568,
0.509631335735321,
0.5174947381019592,
0.35089701414108276,
-0.14296495914459229,
0.17301374673843384,
-0.15263131260871887,
-0.338713675737381,
0.5760737061500549,
-0.38562580943107605,
0.20299512147903442,
0.19470231235027313,
0.24849826097488403,
0.006113079376518726,
-0.17186297476291656,
0.1044362485408783,
-0.23219552636146545,
-0.279531329870224,
-0.46738100051879883,
-0.07719854265451431,
0.22167667746543884,
-0.036761634051799774,
-0.11671716719865799,
0.3956151306629181,
-0.5514797568321228,
-0.1665031909942627,
-0.010535837151110172,
0.12620869278907776,
0.046138133853673935,
0.11083986610174179,
0.04899880290031433,
-0.19757165014743805,
0.7973899841308594,
-0.44961076974868774,
0.7071703672409058,
0.3310989439487457,
0.040616247802972794,
0.3693571090698242,
-0.08458759635686874,
-0.2340756058692932,
0.07022622972726822,
-0.06646248698234558,
0.5951140522956848,
0.42149433493614197,
-0.16483986377716064,
0.31655776500701904,
0.2737233638763428,
-0.06817208975553513,
0.04111567512154579,
0.06847666949033737,
0.15065795183181763,
0.32388293743133545,
0.11582585424184799,
-0.4716070294380188,
-0.6387547850608826,
0.10389599204063416,
0.06060948222875595,
-0.31085750460624695,
-0.4539015591144562,
0.07170286029577255,
-1.0243093967437744,
0.33531826734542847,
-0.044489771127700806,
-0.0005184713518247008,
0.27586230635643005,
0.23210182785987854,
0.2020900994539261,
0.03941323980689049,
-0.13768604397773743,
-0.21453174948692322,
-0.373808890581131,
0.577481210231781,
0.11687187850475311,
-0.005738100036978722,
0.37306585907936096,
0.19154703617095947,
0.34389883279800415,
-0.03605557978153229,
0.07064365595579147,
0.4339936077594757,
0.024587538093328476,
0.27003318071365356,
-0.4162416160106659,
-0.17014996707439423,
-0.1592475324869156,
-0.1725691258907318,
-0.3234490156173706,
0.44347715377807617,
0.6090205311775208,
0.01798381097614765,
-0.37214013934135437,
-0.6714408993721008,
-0.3615850806236267,
-0.6205523014068604,
0.3692795932292938,
-0.48163264989852905,
0.2300439327955246,
-0.04016341641545296,
-0.3786568343639374,
0.09234282374382019,
0.005163467023521662,
-0.11097033321857452,
-0.3262302875518799,
-0.16389930248260498,
0.21169905364513397,
0.05819170922040939,
-0.23215393722057343,
-0.29065704345703125,
-0.0959663838148117,
0.2905336618423462,
0.1839326024055481,
0.37504541873931885,
-0.6755917072296143,
-0.10360805690288544,
0.3357454538345337,
-0.0004949900903739035,
0.10842859745025635,
0.19843322038650513,
-0.0735049620270729,
0.032116904854774475,
-0.04805266857147217,
-0.38571974635124207,
-0.04345329478383064,
-0.6391714811325073,
-0.3881624937057495,
0.4753926694393158,
0.6589318513870239,
0.05313367024064064,
0.14100857079029083,
0.23173147439956665,
-0.6829003095626831,
0.30452898144721985,
0.07095847278833389,
-0.6413589119911194,
0.00812977273017168,
-0.17807917296886444,
0.22732533514499664,
-0.003372316947206855,
0.4265652298927307,
0.21748608350753784,
-0.16570627689361572,
-0.3732842803001404,
0.5096811652183533,
-0.6719207763671875,
1.2309966087341309,
-0.4552549719810486,
-0.09706342965364456,
1.1833996772766113,
0.3121049702167511,
-0.16113810241222382,
0.25573670864105225,
0.23271697759628296,
0.31631341576576233,
-0.015701698139309883,
-0.31024372577667236,
-0.14788031578063965,
-0.22267305850982666,
-0.34628936648368835,
-0.16087540984153748,
0.09084022045135498,
0.4509355127811432,
-0.2552584707736969,
-0.28210684657096863,
-0.4077521860599518,
0.12499339133501053,
-0.2177998274564743,
0.12972764670848846,
0.5309264659881592,
-0.12993444502353668,
-0.3958249092102051,
0.85808265209198,
-0.5077837705612183,
0.7060179710388184,
0.5402247905731201,
-0.16120387613773346,
0.5274413824081421,
0.41994500160217285,
-0.05531065911054611,
0.6982941627502441,
-0.8075317740440369,
0.3713681399822235,
-0.325445294380188,
0.19205324351787567,
-0.779812753200531,
0.11877190321683884,
0.24168433248996735,
0.1991870403289795,
-0.08126978576183319,
0.21320584416389465,
-0.3208290636539459,
-0.398093581199646,
0.5667414665222168,
-0.3767077922821045,
-0.07974366098642349,
0.09281405806541443,
-0.25705933570861816,
-0.4285320043563843,
0.4186875522136688,
-0.8299790024757385,
-0.17820602655410767,
0.0838717371225357,
0.108207568526268,
-0.22169514000415802,
-0.012976299971342087,
0.4053957760334015,
0.18574237823486328,
0.07541526854038239,
-0.08645724505186081,
-0.19710445404052734,
-0.7008161544799805,
-0.313440203666687,
0.46556416153907776,
0.23558971285820007,
0.22308349609375,
0.3669065237045288,
-0.3199656009674072,
-0.4988594949245453,
-0.40188485383987427,
0.5449203848838806,
0.5111638903617859,
0.5657795071601868,
0.1967347413301468,
-0.40807828307151794,
0.17318588495254517,
-0.1935126930475235,
-0.5659850239753723,
0.30255281925201416,
0.7303886413574219,
-0.5270755887031555,
-0.3560034930706024,
0.0857541412115097,
0.1727796047925949,
0.8226320743560791,
-0.2549518346786499,
0.4009198546409607,
-0.6282360553741455,
-0.39080047607421875,
-0.17250442504882812,
-0.013297947123646736,
-0.53611159324646,
-0.13647715747356415,
0.40117305517196655,
-0.09412330389022827,
-0.16863884031772614,
0.4884858727455139,
0.16171985864639282,
0.17495416104793549,
0.6839674115180969,
0.6338287591934204,
0.2751811742782593,
-0.5200257897377014,
0.053926020860672,
-0.32252973318099976,
-0.08273304998874664,
-0.40323948860168457,
-0.21916599571704865,
-0.48736920952796936,
0.06360195577144623,
-6.045377731323242,
0.37081754207611084,
-0.8035145998001099,
-0.1786435842514038,
-0.06183043122291565,
0.08890077471733093,
1.0523651838302612,
0.2433832287788391,
0.2998279929161072,
-0.2375614196062088,
0.20643235743045807,
0.42594727873802185,
-0.10604048520326614,
-0.021155430004000664,
-0.25388824939727783,
0.5572696924209595,
0.3635452091693878,
-0.32146063446998596,
0.027734287083148956,
-0.19783183932304382,
-0.1294422298669815,
-0.1448224037885666,
0.11208350211381912,
0.4626193642616272,
0.4906676709651947,
0.020979391410946846,
-0.9273717403411865,
0.18652065098285675,
-0.3612797260284424,
-0.2784031927585602,
0.14723120629787445,
-0.5491054058074951,
-0.231410413980484,
0.009931636974215508,
0.5530518889427185,
0.04823871701955795,
0.24746941030025482,
0.03955923765897751,
0.11367636173963547,
-0.9994894862174988,
0.07436011731624603,
0.11201825737953186,
-0.13973940908908844,
-0.396731972694397,
-0.0381784662604332,
0.0010355893755331635,
0.13853119313716888,
0.49189507961273193,
-0.07988119125366211,
0.09197305887937546,
0.03799865394830704,
-0.073293037712574,
0.0672929435968399,
0.35064345598220825,
0.3587628901004791,
-0.21334904432296753,
0.12637363374233246,
0.2013167440891266,
-0.5596678853034973,
0.0252848993986845,
0.2544519305229187,
-0.3491615653038025,
-0.3726116716861725,
-0.8904088139533997,
-0.36844000220298767,
0.3356133699417114,
-0.9070310592651367,
-0.06532945483922958,
0.22862540185451508,
-0.04397642984986305,
-0.4031747579574585,
0.14193391799926758,
0.24351082742214203,
-0.286368191242218,
0.588848352432251,
-0.392971009016037,
0.7024651765823364,
0.41612714529037476,
-0.12145880609750748,
-0.4362819194793701,
-0.2097499668598175,
0.03494831174612045,
-0.07842700928449631,
-0.15811407566070557,
0.20845378935337067,
0.023783311247825623,
-0.11714749038219452,
-0.17188620567321777,
-0.09487989544868469,
0.2775384187698364,
0.0829596146941185,
-0.09668624401092529,
0.16251473128795624,
0.7262852191925049,
0.1899941861629486,
0.29771846532821655,
0.28377118706703186,
1.0304315090179443,
0.16908009350299835,
-0.12980756163597107,
0.8059083819389343,
0.0773896872997284,
-0.3529326617717743,
-1.1079638004302979,
-0.4754796028137207,
0.38198336958885193,
-0.709324061870575,
-0.07586921751499176,
0.8869978189468384,
-1.096644639968872,
0.19516703486442566,
0.5309182405471802,
-0.48220211267471313,
-0.41141337156295776,
0.6066367626190186,
-0.20963363349437714,
-0.02849358320236206,
0.4106135070323944,
0.7378441095352173,
-0.30599430203437805,
0.3002915680408478,
0.13003410398960114,
-0.07865359634160995,
0.34476613998413086,
-0.2787361443042755,
-0.3348521590232849,
0.22752077877521515,
0.277904212474823,
-0.6514539122581482,
0.1313900351524353,
0.3685639798641205,
0.21177826821804047,
-0.633342981338501,
0.10678371042013168,
0.2620986998081207,
-0.5400451421737671,
-0.3348541259765625,
-0.05954809859395027,
0.1751183718442917,
0.1528751105070114,
0.4891127049922943,
-0.2439441829919815,
0.00932836439460516,
-0.2645772397518158,
0.08479418605566025,
-0.34011387825012207,
-0.5140635371208191,
-0.13969333469867706,
-0.5553320050239563,
0.5212774872779846,
0.2945234477519989,
0.05700480937957764,
-0.008787804283201694,
-0.33994626998901367,
-0.4071054458618164,
0.6028264760971069,
0.29043450951576233,
-0.13497832417488098,
-0.12077438086271286,
-0.6200414299964905,
0.389456570148468,
0.11042064428329468,
-0.7014414668083191,
-0.4326131045818329,
-0.08609597384929657,
-0.8252128958702087,
-0.34521347284317017,
0.08134841173887253,
-0.21403686702251434,
0.41636455059051514,
0.3704516291618347,
-0.3660432994365692,
-0.036587685346603394,
-0.31128957867622375,
-0.04534568637609482,
0.3283897340297699,
-0.3995615541934967,
0.29316118359565735,
-0.04850313439965248,
0.17217068374156952,
0.47635418176651,
-0.4006560146808624,
-0.3125837445259094,
0.08611509948968887,
0.7686474919319153,
0.3215697109699249,
0.4692927896976471,
0.04002666845917702,
-0.32227444648742676,
-0.004805218428373337,
-0.1730434000492096,
-0.05595617741346359,
0.31902068853378296,
-0.2865070700645447,
-0.10638245940208435,
-0.5321129560470581,
0.3131546378135681,
0.4341934323310852,
-0.35002994537353516,
0.08936123549938202,
0.021776609122753143,
0.20576877892017365,
-0.22935619950294495,
0.35308337211608887,
0.42955389618873596,
-0.17372868955135345,
-0.3011036217212677,
-0.34091296792030334,
-0.39304596185684204,
-0.13026465475559235,
-0.06270505487918854,
-0.5226048231124878,
-0.35963141918182373,
-0.0009776459774002433,
-0.07280388474464417,
0.08855343610048294,
-0.3406943678855896,
-0.6861828565597534,
-0.43972742557525635,
0.25494614243507385,
0.7613705992698669,
-0.13965760171413422,
-0.028613656759262085,
0.16410726308822632,
-0.35185351967811584,
-0.02409343793988228,
0.4979279935359955,
-0.8938900232315063,
0.04916046932339668,
0.11774100363254547,
-0.25725647807121277,
-0.3407413959503174,
0.16676032543182373,
0.459110289812088,
-0.24264168739318848,
-0.007323796395212412,
-0.7466719150543213,
0.008867783471941948,
-0.02646644227206707,
0.514926552772522,
-0.2656969726085663,
0.5860018134117126,
-0.6843271851539612,
-0.7657688856124878,
0.06576433032751083,
0.23443421721458435,
0.12549059092998505,
-0.33930066227912903,
-0.36368557810783386,
-0.044606540352106094,
0.22244687378406525,
-0.5667179822921753,
-0.15658636391162872,
0.05455048382282257,
0.7795301079750061,
0.30750346183776855,
0.14225909113883972,
-0.3998592495918274,
-0.04094836860895157,
-0.01791750080883503,
-0.23435872793197632,
-0.11945231258869171,
-0.18663248419761658,
-0.1612873673439026,
0.11827448010444641,
-0.0032777891028672457,
-0.0798102393746376,
-0.17885299026966095,
0.11518588662147522,
-0.3155520260334015,
-0.18631717562675476,
0.4011603891849518,
0.6792704463005066,
0.3304690718650818,
-0.16377407312393188,
-0.11426747590303421,
0.10904943197965622,
0.22725994884967804,
0.41460558772087097,
-0.0020021393429487944,
-0.5316193103790283,
-0.465914249420166,
0.3306032121181488,
0.13780929148197174,
0.44767627120018005,
-0.32507553696632385,
0.31287136673927307,
-0.5733175873756409,
-0.305650919675827,
-0.45772475004196167,
0.3191952407360077,
0.21205687522888184,
-0.5198209881782532,
0.0654667466878891,
-0.057344771921634674,
0.4673500955104828,
0.6029356718063354,
0.1589750349521637,
0.27690085768699646,
-0.1935235857963562,
-0.0503372959792614,
0.7488113641738892,
0.48260247707366943,
-0.47874337434768677,
0.014519255608320236,
0.238183856010437,
0.4646546244621277,
-0.4075044095516205,
-0.13552884757518768,
-0.5096925497055054,
0.43904513120651245,
-0.07814496010541916,
0.671430766582489,
0.3029756546020508,
0.0987066850066185,
-0.12085331231355667,
-0.23727871477603912,
-0.06153819337487221,
0.2905843257904053,
0.3743642568588257,
-0.28384748101234436,
0.442128986120224,
0.8121327757835388,
0.018852466717362404,
0.11551892757415771,
0.4520055055618286,
0.015829697251319885,
-0.16221983730793,
-0.08316676318645477,
0.736925482749939,
0.26974159479141235,
0.8054962158203125,
0.004483163356781006,
0.15021713078022003,
-0.09346199035644531,
0.18461614847183228,
-0.24651414155960083,
-0.2435460388660431,
-0.37735697627067566,
0.15034958720207214,
0.9673871994018555,
0.5223587155342102,
-0.04766476899385452,
-0.25836092233657837,
0.32359692454338074,
0.4328513443470001,
0.024226566776633263,
0.22823075950145721,
0.08849816769361496,
-0.1095799133181572,
0.16913935542106628,
-0.31075674295425415,
-0.11658205837011337,
0.007371196523308754,
-0.22033469378948212,
-0.15780304372310638,
0.1666284203529358,
-0.11258454620838165,
-0.5896003842353821,
0.2437802255153656,
-0.22371578216552734,
0.10464327037334442,
0.04111992567777634,
0.13396257162094116,
-0.3662540018558502,
-0.4251704812049866,
0.4467651844024658,
0.36095863580703735,
0.08401703834533691,
-0.11548016220331192,
0.11891071498394012,
0.07385949045419693,
-0.9143510460853577,
0.24030135571956635,
-0.13859370350837708,
-0.4278128445148468,
0.46384406089782715,
0.07084542512893677,
0.31898459792137146,
0.277729332447052,
-0.4631994664669037,
-0.17677409946918488,
0.11312365531921387,
-0.23991349339485168,
0.4316330850124359,
-0.12638631463050842,
-0.4008420407772064,
0.09770265966653824,
0.3459892272949219,
0.2932063043117523,
0.06630861014127731,
-0.7730241417884827,
0.0767875388264656,
-0.11147657781839371,
-0.3882669508457184,
-0.11882445961236954,
-0.29343459010124207,
0.2663094401359558,
0.4183078110218048,
0.37804651260375977,
-0.45199453830718994,
-0.047963179647922516,
0.11056029796600342,
0.043189164251089096,
-0.43205729126930237,
0.5934423804283142,
-0.7027727365493774,
-0.25468510389328003,
-0.28174909949302673,
0.06069768965244293,
0.5440375804901123,
0.31572288274765015,
-0.6564711928367615,
0.19271157681941986,
-0.3344913125038147,
0.011031684465706348,
0.35665377974510193,
-0.3149148225784302,
0.10910199582576752,
-0.39486759901046753,
-0.22420307993888855,
0.03564408794045448,
0.2556282877922058,
-0.015239491127431393,
-0.44784411787986755,
0.18621526658535004,
0.14676536619663239,
0.5148252248764038,
0.34241652488708496,
0.4772607684135437,
-0.3208836615085602,
-0.2661800682544708,
-0.3736530840396881,
0.33733946084976196,
-0.5294755697250366,
0.34448134899139404,
-0.138363316655159,
0.4206252694129944,
0.29116183519363403,
-0.27777835726737976,
-0.11226476728916168,
-0.21047084033489227,
-0.12234246730804443,
0.19275029003620148,
0.24132795631885529,
0.5707207322120667,
-0.1995864361524582,
-0.19098368287086487,
-0.9176616668701172,
0.36720719933509827,
-0.5576235055923462,
-0.6561152935028076,
0.17803435027599335,
-0.4889138340950012,
-0.3859909474849701,
-0.27084770798683167,
-0.12657801806926727,
-0.220267191529274,
-0.025957122445106506,
-0.16872411966323853
] |
THE use of formal devices for assessing function is becoming standard in agencies serving the elderly. In the Gerontological Society's recent contract study on functional assessment (Howell, 1968), a large assortment of rating scales, checklists, and other techniques in use in applied settings was easily assembled. The present state of the trade seems to be one in which each investigator or practitioner feels an inner compusion to make his own scale and to cry that other existent scales cannot possibly fit his own setting. The authors join this company in presenting two scales first standardized on their own population (Lawton, 1969). They take some comfort, however, in the fact that one scale, the Physical Self-Maintenance Scale (PSMS), is largely a scale developed and used by other investigators (Lowenthal, 1964), which was adapted for use in our own institution. The second of the scales, the Instrumental Activities of Daily Living Scale (IADL), taps a level of functioning heretofore inadequately represented in attempts to assess everyday functional competence. Both of the scales have been tested further for their usefulness in a variety of types of institutions and other facilities serving community-resident older people. Before describing in detail the behavior measured by these two scales, we shall briefly describe the schema of competence into which these behaviors fit (Lawton, 1969). Human behavior is viewed as varying in the degree of complexity required for functioning in a variety of tasks. The lowest level is called life maintenance, followed by the successively more complex levels of func- | [
0.012476101517677307,
0.006935961544513702,
-0.010790305212140083,
0.00700726080685854,
0.006757878232747316,
0.0036715215537697077,
0.006856671534478664,
-0.008344173431396484,
-0.014870831742882729,
-0.0037533477880060673,
-0.008333699777722359,
0.007833747193217278,
0.006173970177769661,
-0.005743483547121286,
-0.013337863609194756,
-0.004042120184749365,
-0.020588207989931107,
0.01808870956301689,
0.011963929980993271,
-0.0018841829150915146,
0.0019410131499171257,
0.0018477673875167966,
0.008837172761559486,
0.02334253117442131,
0.006112042814493179,
-0.0072332420386374,
-0.010524990037083626,
0.0074791074730455875,
0.02029479295015335,
-0.0009075705893337727,
-0.0013074374292045832,
-0.014956970699131489,
-0.008816860616207123,
-0.0028799548745155334,
0.008382569067180157,
-0.006400289013981819,
0.00039467570604756474,
0.011738419532775879,
-0.014469757676124573,
-0.002182510681450367,
-0.009022894315421581,
-0.007015462964773178,
-0.0064296964555978775,
0.017968598753213882,
-0.008004093542695045,
-0.009243999607861042,
-0.007152968551963568,
0.0018227456603199244,
-0.023613087832927704,
0.008476626127958298,
-0.01856362633407116,
-0.0000126594677567482,
0.0024491394869983196,
0.015073125250637531,
-0.004883844405412674,
-0.0025910339318215847,
0.01673225313425064,
0.0011096205562353134,
0.0021598865278065205,
0.012300190515816212,
-0.016788437962532043,
-0.0009777462109923363,
-0.003183273132890463,
-0.00463438592851162,
-0.006911641452461481,
-0.06746606528759003,
-0.014280303381383419,
0.016407351940870285,
0.01749010570347309,
-0.02530720829963684,
0.001860148273408413,
0.011408055201172829,
-0.02529136836528778,
-0.009061753749847412,
0.0005729245021939278,
0.018842855468392372,
-0.002305201720446348,
-0.011974845081567764,
0.0011457395739853382,
-0.01672453060746193,
-0.00347679341211915,
-0.009579806588590145,
0.02107415720820427,
0.020182538777589798,
0.0005739666521549225,
0.002051824936643243,
0.009123354218900204,
0.00738219590857625,
0.007290021516382694,
0.011828962713479996,
-0.007286646869033575,
0.004208779893815517,
0.0027532349340617657,
-0.011438645422458649,
-0.006039069499820471,
-0.010860016569495201,
0.0032621780410408974,
0.0036732940934598446,
0.00425860146060586,
-0.007987520657479763,
-0.002771304454654455,
0.014924755319952965,
0.01762247085571289,
-0.006532435305416584,
-0.000677457544952631,
0.008789526298642159,
0.0008041709661483765,
-0.008418445475399494,
-0.0022008507512509823,
0.003847976680845022,
-0.018498986959457397,
0.01762167550623417,
0.005533784627914429,
0.0244172103703022,
0.0030644950456917286,
-0.023001082241535187,
0.012564407661557198,
-0.011135242879390717,
0.004738382063806057,
-0.02323361672461033,
0.027160916477441788,
-0.010100577026605606,
0.013365034013986588,
-0.009938675910234451,
-0.002444801153615117,
0.02418604865670204,
-0.023629862815141678,
0.012475745752453804,
0.005989660508930683,
0.00641194311901927,
-0.007401300594210625,
-0.008605433627963066,
0.008028827607631683,
-0.006558621302247047,
0.006531850900501013,
-0.006288183853030205,
-0.0043615009635686874,
0.009568111039698124,
0.009984290227293968,
-0.002414166461676359,
-0.008342195302248001,
0.005993281491100788,
0.0021646306850016117,
0.01654040440917015,
0.020486779510974884,
-0.005175312981009483,
0.007451329380273819,
0.0077943988144397736,
-0.0017398176714777946,
-0.0020143494475632906,
0.0012827038299292326,
-0.007210187613964081,
-0.0003542006015777588,
-0.01393237803131342,
0.0174725204706192,
0.0013751392252743244,
-0.0033123281318694353,
-0.008390109054744244,
-0.01383857149630785,
-0.0012814230285584927,
0.011568943969905376,
0.00763243343681097,
0.012288231402635574,
0.0075942883267998695,
-0.002285416703671217,
0.0057198540307581425,
0.0020148640032857656,
0.0023277418222278357,
-0.015975724905729294,
-0.001936674932949245,
-0.012533972039818764,
0.011883595958352089,
0.0034561962820589542,
0.009617658331990242,
-0.001731768948957324,
-0.0031321668066084385,
0.00392116978764534,
0.007826738059520721,
-0.021732790395617485,
0.06726783514022827,
-0.002956417156383395,
-0.004645836539566517,
0.0036630071699619293,
0.017804190516471863,
0.010067756287753582,
-0.01104019396007061,
0.02067450061440468,
-0.0019258864922448993,
0.007742245681583881,
0.010931629687547684,
-0.013773312792181969,
-0.009337693452835083,
0.0025631480384618044,
0.008289484307169914,
0.0021254373714327812,
0.0022782287560403347,
0.006948171183466911,
0.004038907587528229,
-0.004925102926790714,
-0.014323534443974495,
0.007006748579442501,
0.012909673154354095,
0.021145641803741455,
0.0058203209191560745,
-0.011717131361365318,
0.009259596467018127,
0.019845545291900635,
-0.02224479243159294,
0.008807637728750706,
-0.0032760407775640488,
-0.006700490601360798,
0.0026958987582474947,
0.014296116307377815,
-0.008213766850531101,
0.0042371065355837345,
0.0044379401952028275,
0.0021758200600743294,
0.0010352882090955973,
0.018000980839133263,
-0.018368244171142578,
0.004232991486787796,
-0.014593866653740406,
0.043872520327568054,
-0.006823625415563583,
0.0028635170310735703,
0.008915241807699203,
0.0055635953322052956,
0.013919360004365444,
0.0120879877358675,
0.010116726160049438,
-0.012265516445040703,
0.01123654656112194,
-0.007099750451743603,
0.004881701897829771,
0.010529560968279839,
0.03076138347387314,
0.012287970632314682,
-0.011546547524631023,
0.004776328802108765,
-0.009624838829040527,
-0.008915252052247524,
-0.01308543048799038,
0.01352134719491005,
-0.0027624003123492002,
-0.004117005504667759,
0.0017480698879808187,
0.005950251594185829,
-0.009628928266465664,
-0.007602027151733637,
-0.0025098584592342377,
0.0004319233703427017,
0.012211340479552746,
0.00043304695282131433,
0.00027333502657711506,
0.030158739537000656,
0.005551122594624758,
0.012766548432409763,
0.0068089934065938,
0.020206362009048462,
0.007137367967516184,
0.0044284421019256115,
0.001701079891063273,
0.0035698949359357357,
-0.003873331006616354,
0.006773326545953751,
0.007267835550010204,
0.01496710255742073,
-0.011603021994233131,
0.0037094643339514732,
-0.01981743425130844,
0.003360939910635352,
-0.012226409278810024,
0.0015280540101230145,
-0.08123824000358582,
-0.0155416801571846,
0.01583029329776764,
0.03165416792035103,
0.001493278075940907,
0.023068130016326904,
0.004572381731122732,
0.0073282052762806416,
-0.0008700857870280743,
-0.024463366717100143,
-0.0035971244797110558,
0.0037335362285375595,
-0.00953786913305521,
-0.0016004728386178613,
-0.00226797629147768,
-0.0019232919439673424,
0.006745157763361931,
-0.018053974956274033,
-0.01631923019886017,
0.042235665023326874,
0.005009977612644434,
0.0035983354318886995,
0.010991882532835007,
-0.0017804227536544204,
0.00461406959220767,
-0.035282284021377563,
0.02941826730966568,
0.0001003975048661232,
-0.02559082955121994,
0.0003722684923559427,
0.004046753980219364,
0.00711862463504076,
-0.009485339745879173,
0.005053344648331404,
0.025916380807757378,
0.024483682587742805,
-0.0024056665133684874,
0.000015269732102751732,
-0.0002289449330419302,
-0.0033321287482976913,
0.0035866210237145424,
0.007098402362316847,
0.0031898333691060543,
0.0045776525512337685,
-0.012066390365362167,
-0.02005769871175289,
0.0021510727237910032,
0.016672732308506966,
0.018936697393655777,
-0.014898495748639107,
0.01938026398420334,
-0.005777649115771055,
0.0047927130945026875,
0.010400332510471344,
-0.022690076380968094,
0.0097269332036376,
-0.0006488082581199706,
0.005604548379778862,
-0.007705517578870058,
0.004757620859891176,
-0.01486226823180914,
-0.016269657760858536,
-0.01687908172607422,
0.0010569035075604916,
0.006689682602882385,
-0.0049868179485201836,
-0.0005732282297685742,
-0.005336173810064793,
-0.005294576287269592,
0.020727116614580154,
0.00991407036781311,
-0.003823219332844019,
0.018708892166614532,
-0.007879607379436493,
-0.0012776954099535942,
-0.0076749264262616634,
-0.011561010032892227,
0.004345177207142115,
0.0019111251458525658,
-0.006240506656467915,
0.013985523022711277,
0.008951585739850998,
-0.00012824079021811485,
0.0018730596639215946,
-0.009801937267184258,
-0.010223209857940674,
0.009869426488876343,
-0.015514333732426167,
0.015397002920508385,
-0.016029084101319313,
-0.01306534931063652,
-0.01958342269062996,
-0.0048006330616772175,
0.00691958935931325,
0.012449209578335285,
-0.009875671938061714,
0.010704105719923973,
-0.0017305421642959118,
0.012723276391625404,
0.009074850007891655,
-0.0070884632878005505,
-0.0012632771395146847,
0.024799901992082596,
-0.017467711120843887,
-0.014492305926978588,
0.0076752533204853535,
-0.0011630603112280369,
-0.003535693744197488,
0.009172121062874794,
-0.007522099185734987,
-0.009274903684854507,
0.00020824233070015907,
-0.004241738468408585,
0.01796400360763073,
0.005058034788817167,
0.01123310998082161,
0.006182072218507528,
-0.007393873296678066,
0.07371535897254944,
0.0103900246322155,
0.0167190320789814,
-0.008217035792768002,
0.021611781790852547,
-0.0058962032198905945,
0.005727623589336872,
-0.017514625564217567,
0.006576384883373976,
-0.0007298276759684086,
0.008713476359844208,
0.029005462303757668,
0.005861954763531685,
0.0021765287965536118,
-0.00011700717732310295,
-0.008847123011946678,
0.013390205800533295,
0.006729493383318186,
0.01053407322615385,
-0.015058567747473717,
-0.0021173814311623573,
0.004764444660395384,
0.007053297478705645,
-0.021258879452943802,
0.00822470709681511,
0.021203037351369858,
-0.027727346867322922,
-0.013372493907809258,
0.010106729343533516,
0.004717998206615448,
0.0040521216578781605,
0.03217126429080963,
-0.002479339949786663,
-0.019664281979203224,
0.011380518786609173,
0.01945842057466507,
-0.008713189512491226,
-0.009586787782609463,
0.010327070951461792,
0.01709243468940258,
-0.004530441015958786,
-0.01208029966801405,
0.00044584181159734726,
0.007352321408689022,
0.0160642359405756,
0.011006384156644344,
-0.001803186722099781,
-0.004046158865094185,
-0.005953731015324593,
0.02888786979019642,
-0.011623455211520195,
0.014177937060594559,
0.007346099242568016,
-0.007865410298109055,
-0.006755771115422249,
0.013304756954312325,
0.016953296959400177,
-0.003860674099996686,
0.01173655316233635,
-0.0029956272337585688,
-0.0036335454788058996,
0.0009906822815537453,
0.009660942479968071,
-0.028006142005324364,
0.0002548922784626484,
0.0018481983570382,
0.013416212052106857,
-0.013302085921168327,
-0.007480718195438385,
0.013580422848463058,
-0.001494954340159893,
0.01316966861486435,
0.0008638077415525913,
-0.013575313612818718,
0.005655825138092041,
-0.039942145347595215,
-0.007903771474957466,
0.006100504659116268,
0.0035572065971791744,
0.007805286906659603,
-0.020679950714111328,
0.007266325876116753,
-0.00741867208853364,
-0.022757917642593384,
0.010397288016974926,
0.022105522453784943,
-0.0015530604869127274,
-0.07485784590244293,
0.005135722458362579,
0.01189388521015644,
-0.00516740046441555,
-0.012930573895573616,
0.03389742225408554,
-0.021875794976949692,
0.006822824012488127,
-0.013144333846867085,
-0.009851483628153801,
-0.028696522116661072,
0.00920975673943758,
0.03400187939405441,
-0.001808959525078535,
0.011471912264823914,
-0.014147725887596607,
-0.021147944033145905,
-0.0033412398770451546,
0.0008350436110049486,
0.006225107237696648,
-0.007073306478559971,
0.03358706831932068,
0.01676284894347191,
-0.0032590688206255436,
0.0007532511372119188,
-0.08228456974029541,
0.0044990405440330505,
-0.0006849127821624279,
-0.004636627621948719,
-0.007630791515111923,
0.003576558083295822,
0.004085676744580269,
-0.008046481758356094,
-0.0008891314500942826,
-0.011332975700497627,
-0.01902148872613907,
-0.007578510791063309,
0.00863416213542223,
0.010233190841972828,
0.0050348504446446896,
-0.0012210157001391053,
0.012991145253181458,
0.001230509951710701,
0.0010236470261588693,
0.005459074396640062,
-0.0014588907361030579,
0.005802659317851067,
-0.0047386023215949535,
0.004171454347670078,
-0.003218701109290123,
-0.008346755988895893,
0.00020127138122916222,
0.001167216687463224,
0.014196628704667091,
-0.0033678615000098944,
0.007861931808292866,
0.005242674145847559,
0.009056012146174908,
-0.01841440238058567,
-0.004448642022907734,
-0.01435248926281929,
-0.025862431153655052,
-0.014653099700808525,
-0.02418254315853119,
-0.004181168973445892,
0.00004874600563198328,
0.016842564567923546,
-0.014708902686834335,
-0.012026175856590271,
0.014262187294661999,
-0.004379036836326122,
0.002515866421163082,
-0.00422130711376667,
-0.00010706769535318017,
0.014068185351788998,
0.013563260436058044,
0.010915149934589863,
0.013713297434151173,
0.020019499585032463,
0.013352867215871811,
0.009395995177328587,
0.0008534781518392265,
0.0018475840333849192,
0.009983690455555916,
0.010493168607354164,
0.002094138879328966,
0.01164233312010765,
-0.013169417157769203,
0.07255295664072037,
-0.018952785059809685,
0.019212108105421066,
-0.009347070008516312,
-0.012785064056515694,
-0.0030282798688858747,
0.022381719201803207,
-0.03617563098669052,
0.008803370408713818,
0.010016422718763351,
0.003035296918824315,
-0.00437234528362751,
0.03101486712694168,
0.004166008904576302,
-0.01709354668855667,
0.0027355989441275597,
-0.015545913949608803,
0.020123213529586792,
-0.015919003635644913,
0.0005092262290418148,
0.006590258330106735,
0.002487493446096778,
-0.0008119437843561172,
0.008504170924425125,
-0.009005791507661343,
0.008581392467021942,
0.004819609224796295,
0.01270066387951374,
-0.004536786116659641,
-0.03330008685588837,
-0.009598412550985813,
-0.01790432818233967,
0.0037905285134911537,
-0.007207847200334072,
0.025431182235479355,
0.007530319504439831,
0.007488098926842213,
0.00499814422801137,
0.0009374252986162901,
-0.005782861728221178,
0.027445228770375252,
0.0026137325912714005,
0.007055650465190411,
0.005730100441724062,
0.014572996646165848,
-0.0030723493546247482,
0.01981329545378685,
-0.001803868217393756,
0.005667336750775576,
0.0006065468769520521,
-0.008445060811936855,
0.0039986176416277885,
-0.008933143690228462,
-0.02306313067674637,
0.001677586929872632,
0.001357370987534523,
0.0301513634622097,
0.016999974846839905,
-0.00977354310452938,
-0.014580893330276012,
0.0001279708230867982,
-0.006386883556842804,
0.01674763113260269,
0.0007677448447793722,
0.009302034042775631,
0.01183028519153595,
0.006548234261572361,
-0.004533061757683754,
-0.0018770541064441204,
0.011262442916631699,
-0.016747277230024338,
-0.0002397878561168909,
-0.0001387254160363227,
-0.0050536710768938065,
-0.005826880224049091,
0.0068562631495296955,
-0.020110176876187325,
0.003711448749527335,
0.00845838151872158,
0.009233677759766579,
-0.01063008327037096,
0.015577737241983414,
-0.0018643196672201157,
0.011448903940618038,
-0.008112853392958641,
0.011392827145755291,
0.007326669991016388,
0.013278531841933727,
-0.006935254205018282,
0.005472405813634396,
0.01229447778314352,
0.012624755501747131,
0.0015005709137767553,
0.00582023523747921,
0.007434026803821325,
0.031985633075237274,
0.012475060299038887,
0.0034747296012938023,
-0.01252648327499628,
-0.005738197825849056,
-0.005321665201336145,
0.02278290130198002,
0.011399192735552788,
0.012280135415494442,
-0.014555167406797409,
-0.015918023884296417,
-0.01110989972949028,
0.04214140400290489,
-0.01289821695536375,
-0.01901070959866047,
-0.01170278899371624,
0.029731089249253273,
0.031928882002830505,
-0.011605101637542248,
-0.033955369144678116,
-0.003517657984048128,
-0.009144817478954792,
0.004372814204543829,
0.006822619121521711,
-0.009648764505982399,
-0.0063862367533147335,
-0.016621006652712822,
-0.0005542165599763393,
0.011112174950540066,
0.014113595709204674,
-0.006255136802792549,
-0.002175059635192156,
-0.006836512126028538,
0.013677426613867283,
-0.015386034734547138,
-0.004555116407573223,
0.0066201891750097275,
0.012212272733449936,
0.009444199502468109,
0.0014300812035799026,
-0.0079796202480793,
0.012704247608780861,
0.006786712445318699,
-0.006329923402518034,
0.0027882081922143698,
0.00787826906889677,
-0.002160601783543825,
-0.006581213790923357,
0.024492017924785614,
0.008691966533660889,
-0.006736721843481064,
-0.004044106230139732,
0.0031406860798597336,
0.003275563707575202,
-0.0006769794272258878,
0.00032180582638829947,
0.000178723712451756,
-0.02282029762864113,
-0.0013028314569965005,
-0.017772046849131584,
0.015439207665622234,
0.0016633644700050354,
0.013410832732915878,
-0.02028873935341835,
0.01086621917784214,
-0.0052857366390526295,
-0.011579861864447594,
-0.00971413217484951,
-0.003196852747350931,
-0.032429423183202744,
0.014849293045699596,
-0.009355533868074417,
0.015810227021574974,
0.004271811805665493,
0.013151809573173523,
-0.008460156619548798,
-0.03651256859302521,
-0.019541440531611443,
-0.0002415014896541834,
0.001518858945928514,
-0.008947654627263546,
0.004447802435606718,
0.00806016381829977,
-0.01654977723956108,
0.0015880847349762917,
0.003440908621996641,
-0.008312352932989597,
-0.012315422296524048,
-0.009259004145860672,
0.0012699486687779427,
-0.007313686888664961,
-0.008507396094501019,
0.01414518617093563,
-0.0040606604889035225,
0.02217070572078228,
-0.01820891536772251,
-0.024223048239946365,
-0.02767135016620159,
0.02201705053448677,
-0.004819836467504501,
0.01280947495251894,
0.003677364904433489,
-0.03094109520316124,
0.0067998552694916725,
0.010760510340332985,
-0.000730950734578073,
-0.009003362618386745
] | [
0.31903916597366333,
0.16474030911922455,
0.4066639542579651,
-0.027637692168354988,
-0.06289604306221008,
0.4025407135486603,
0.5182182788848877,
-0.5157039165496826,
-0.1425797939300537,
-0.6130574345588684,
0.2181859016418457,
0.6982333064079285,
0.05711129307746887,
-0.00008699505269760266,
-0.5052968263626099,
0.39322370290756226,
0.6719684600830078,
0.004505813587456942,
0.029833029955625534,
0.2509131133556366,
-0.7135656476020813,
0.038614191114902496,
0.10266894102096558,
-0.5161851048469543,
0.0018625648226588964,
0.3844451904296875,
0.4746176302433014,
-0.08435669541358948,
-0.582275927066803,
-0.0016995772020891309,
0.2536342442035675,
0.5047242045402527,
-0.3611171245574951,
-0.1509055495262146,
-0.24375474452972412,
-0.011170576326549053,
0.18772579729557037,
-0.40722811222076416,
0.2537091374397278,
-0.5917609333992004,
0.14196592569351196,
-0.09092965722084045,
0.22029879689216614,
0.06592829525470734,
-0.6638084650039673,
-0.2414708435535431,
-2.005274534225464,
-0.245855912566185,
-1.0007559061050415,
0.5089677572250366,
-0.37780267000198364,
0.5681470036506653,
0.35372281074523926,
0.33368465304374695,
-0.07468003034591675,
0.25780755281448364,
-0.057906437665224075,
-0.016996566206216812,
0.2412584275007248,
-0.721716046333313,
0.5709479451179504,
0.27259960770606995,
0.4232601225376129,
0.09993229061365128,
-0.22628533840179443,
0.037811119109392166,
0.16499389708042145,
-0.16829179227352142,
-0.13003861904144287,
0.2215426117181778,
0.19012704491615295,
-0.5022770762443542,
-0.3023867905139923,
0.05489596351981163,
-0.37143200635910034,
0.08937109261751175,
0.15236565470695496,
-0.56068354845047,
0.15305854380130768,
-0.17712536454200745,
-0.025017492473125458,
0.18494439125061035,
0.43418410420417786,
-0.08950470387935638,
0.404735267162323,
0.0022288106847554445,
0.22046056389808655,
0.4671945869922638,
-0.06787022948265076,
0.29678961634635925,
0.12833662331104279,
-0.45744937658309937,
0.4305604100227356,
0.22423267364501953,
-0.015857946127653122,
-0.12901192903518677,
0.5963897109031677,
-0.28196802735328674,
0.11583491414785385,
-0.03571726754307747,
0.23499520123004913,
-0.08848100900650024,
0.2830958664417267,
-0.0712905079126358,
0.28402915596961975,
-0.27694666385650635,
0.3545878529548645,
-0.5099604725837708,
-0.11313626170158386,
0.23766860365867615,
-0.6650351881980896,
0.15141844749450684,
0.13386346399784088,
0.21801957488059998,
-0.16454869508743286,
-0.034843217581510544,
0.200905904173851,
0.11573738604784012,
-0.4226124584674835,
0.20840758085250854,
0.3876807391643524,
0.29049578309059143,
0.16357657313346863,
-0.08786703646183014,
0.05190006271004677,
0.12727439403533936,
0.4498182535171509,
0.6696326732635498,
-0.3526257872581482,
0.20033006370067596,
-0.006072009913623333,
0.25300344824790955,
-0.07955949008464813,
-0.6154824495315552,
-0.04735511541366577,
-0.25979936122894287,
0.3680996000766754,
0.01357156503945589,
-0.05323994159698486,
0.433467835187912,
0.05345521494746208,
-0.0990666076540947,
-0.4165063798427582,
-0.3336017429828644,
-0.05661793798208237,
-0.6454947590827942,
0.36891934275627136,
-0.0414949506521225,
-0.47180408239364624,
0.029356932267546654,
-0.11110284179449081,
0.25197187066078186,
0.04122122749686241,
-0.17626391351222992,
0.444814532995224,
0.5224772095680237,
-0.13946129381656647,
-0.20509079098701477,
-0.04954235255718231,
-0.27874842286109924,
-0.24765342473983765,
0.24080166220664978,
-0.7148390412330627,
-0.07331261038780212,
0.2180880606174469,
-0.2569432854652405,
-0.07616884261369705,
0.3642621338367462,
0.4396885931491852,
0.21222539246082306,
0.359952837228775,
-0.2785617411136627,
-0.06977231055498123,
-0.09162196516990662,
-0.7132735252380371,
0.3441944718360901,
0.5180023908615112,
0.16107285022735596,
0.2791789770126343,
0.091790109872818,
-0.595873236656189,
-0.10987325012683868,
0.23807397484779358,
-0.44238245487213135,
0.3015332818031311,
-0.00966550875455141,
0.5402264595031738,
-0.200555220246315,
-0.4352019429206848,
-0.4356330335140228,
0.21254515647888184,
-0.4474905729293823,
0.3488520681858063,
-0.5501672029495239,
1.1754013299942017,
-0.14862753450870514,
-0.5190615653991699,
0.9803748726844788,
-0.30763840675354004,
-0.09616627544164658,
0.2621345520019531,
0.0997704565525055,
0.07004332542419434,
0.16106297075748444,
-0.17857713997364044,
-0.08878130465745926,
-0.23309171199798584,
0.29348477721214294,
-0.4530685842037201,
-0.08699098229408264,
0.7170678377151489,
-1.0181610584259033,
-0.1581704169511795,
-0.14714939892292023,
-0.16204410791397095,
0.09316527098417282,
0.028660563752055168,
0.21849317848682404,
-0.20917433500289917,
-0.28646162152290344,
0.6265780329704285,
-0.25020191073417664,
0.2264026701450348,
0.31461507081985474,
-0.028846316039562225,
0.2233443409204483,
0.5620185732841492,
-0.0676889419555664,
0.38165247440338135,
-0.7158196568489075,
0.08040408045053482,
-0.09408668428659439,
0.4586305320262909,
-0.4209742248058319,
0.0908246785402298,
0.04352627694606781,
-0.0029716843273490667,
-0.24655206501483917,
-0.038760457187891006,
-0.1859348863363266,
-0.13337673246860504,
-0.19418485462665558,
-0.22178226709365845,
0.5507858395576477,
0.5385869741439819,
-0.33366063237190247,
-0.36349648237228394,
0.4357079267501831,
-0.32424017786979675,
-0.05259139463305473,
-0.2254907786846161,
0.5292486548423767,
0.07475105673074722,
0.10542972385883331,
0.29469385743141174,
0.1557493656873703,
-0.024301044642925262,
0.008566262200474739,
0.3066669702529907,
-0.07243869453668594,
-0.38466790318489075,
0.39675986766815186,
0.13111943006515503,
0.23107551038265228,
-0.10150539129972458,
-0.2824689447879791,
-0.32135266065597534,
-0.6116846203804016,
0.49383240938186646,
0.7242445349693298,
0.5249507427215576,
0.10588425397872925,
-0.4775267243385315,
0.18669237196445465,
0.19220536947250366,
-0.3317561447620392,
0.3126562535762787,
0.29822149872779846,
-0.36869561672210693,
-0.22883343696594238,
0.1915043294429779,
0.5837397575378418,
1.224368929862976,
-0.4739139676094055,
-0.09602586179971695,
-0.5309737324714661,
0.11868485063314438,
-0.45530885457992554,
0.059904780238866806,
0.12899978458881378,
-0.023349177092313766,
0.6997921466827393,
-0.263978511095047,
-0.5571290254592896,
0.23962725698947906,
0.46457186341285706,
-0.04037835821509361,
0.25803422927856445,
-0.0422089584171772,
-0.15815997123718262,
-0.28663989901542664,
0.44749581813812256,
0.08659352362155914,
-0.04861379787325859,
-0.041758377104997635,
-0.300094872713089,
-0.11564932763576508,
-0.14385153353214264,
-6.1901021003723145,
-0.43908193707466125,
-0.62164306640625,
-0.4435407221317291,
0.14473305642604828,
0.2624741196632385,
0.8897055983543396,
-0.11292805522680283,
-0.08325643837451935,
0.3757213056087494,
0.31722575426101685,
0.15588051080703735,
0.26217779517173767,
0.5818602442741394,
0.4406995177268982,
0.2731180489063263,
-0.14282438158988953,
0.04060760885477066,
-0.3663899600505829,
0.03557118773460388,
0.3780994713306427,
-0.5295737981796265,
0.19185078144073486,
0.69717937707901,
-0.1256808638572693,
0.2196015864610672,
-0.9825827479362488,
0.5503205060958862,
-0.08414437621831894,
-0.07235947251319885,
0.07899194955825806,
0.020791033282876015,
-0.49833768606185913,
-0.41904008388519287,
0.43589070439338684,
0.32477328181266785,
0.3604537844657898,
-0.06788787990808487,
0.3888109028339386,
-0.6520190238952637,
-0.004343732725828886,
0.7040823698043823,
0.180789977312088,
-0.19829122722148895,
-0.09092500060796738,
0.0235372893512249,
-0.18247589468955994,
0.1773063987493515,
-0.49195414781570435,
0.37261128425598145,
-0.12007880955934525,
0.007749931886792183,
0.05775298550724983,
-0.19498327374458313,
0.21489039063453674,
-0.5511052012443542,
-0.023815175518393517,
0.3989119827747345,
-0.2143687605857849,
0.13634607195854187,
-0.27355533838272095,
-0.21512046456336975,
-0.12951873242855072,
-0.8963872194290161,
-0.4211540222167969,
-0.003022849326953292,
-1.0553324222564697,
-0.28156790137290955,
0.2690153121948242,
0.09105316549539566,
-0.6555321216583252,
0.10722288489341736,
0.018320690840482712,
-0.6791586875915527,
0.3629898130893707,
-0.07965493202209473,
0.6001927852630615,
0.11155425757169724,
0.42099013924598694,
0.2503490149974823,
-0.34102141857147217,
-0.37971583008766174,
0.05479196086525917,
-0.034179188311100006,
0.26750829815864563,
-0.25149255990982056,
-0.36393633484840393,
0.22849567234516144,
-0.2838481366634369,
-0.10744084417819977,
0.6922490000724792,
0.1302735060453415,
0.027352912351489067,
0.302491694688797,
0.2839468717575073,
0.48534610867500305,
0.19658896327018738,
-0.09438861906528473,
-0.008444724604487419,
-0.29160135984420776,
0.352964848279953,
0.04827793315052986,
-0.14345882833003998,
-0.4797048270702362,
0.10473767668008804,
-0.14493708312511444,
-1.2444792985916138,
0.22963517904281616,
0.5275112390518188,
-0.6084679365158081,
-0.46955129504203796,
-0.09615781158208847,
-0.260816365480423,
-0.3987073600292206,
0.2501301169395447,
-0.10563336312770844,
-0.21945995092391968,
-0.09039267152547836,
-0.011265444569289684,
-0.17324014008045197,
-0.018481338396668434,
0.004291640594601631,
0.15602914988994598,
-0.17388387024402618,
-0.3667719066143036,
-0.13229508697986603,
-0.033737633377313614,
0.40944889187812805,
-0.22293198108673096,
0.5112546682357788,
0.49302902817726135,
0.5117660760879517,
-0.3604266345500946,
0.3886295557022095,
0.1943536251783371,
-0.24021850526332855,
-0.3138776421546936,
0.6512040495872498,
-0.11623723059892654,
-0.4187775254249573,
0.5940496921539307,
-0.3074977695941925,
0.04389233887195587,
-0.14303794503211975,
0.30172649025917053,
-0.29732227325439453,
0.16232585906982422,
-0.16809307038784027,
0.050654444843530655,
0.45041346549987793,
0.199527308344841,
-0.2726820707321167,
-0.023987077176570892,
-0.025559786707162857,
-0.31733521819114685,
-0.28217649459838867,
0.25717270374298096,
-0.14914244413375854,
-0.47238415479660034,
-0.2564387321472168,
-0.1906583458185196,
0.503486156463623,
-1.0465272665023804,
-0.23541808128356934,
0.2050662338733673,
-0.3182169198989868,
-0.7410070896148682,
-0.051899731159210205,
0.26390358805656433,
0.30537012219429016,
0.1604403555393219,
-0.5160958766937256,
-0.15963560342788696,
-0.32082998752593994,
0.07332136482000351,
0.23269684612751007,
-0.17924591898918152,
0.2772393524646759,
-0.3268565237522125,
-0.011339159682393074,
0.45240020751953125,
-0.4375605881214142,
-0.6544473171234131,
-0.005589902866631746,
0.42082518339157104,
-0.1938924491405487,
0.28672245144844055,
-0.12820453941822052,
-0.09479312598705292,
-0.3249746561050415,
0.3487071692943573,
-0.01750185340642929,
0.6647734045982361,
0.2593810558319092,
-0.2304765284061432,
-0.32718905806541443,
0.3249572515487671,
0.49392881989479065,
-0.4232535660266876,
0.24813726544380188,
0.3857992887496948,
-0.13585615158081055,
-0.2718876004219055,
-0.38265055418014526,
0.48567795753479004,
-0.9176016449928284,
0.3344164192676544,
-0.26755383610725403,
-0.5558907389640808,
0.2158351093530655,
-0.5326181650161743,
-0.1885528862476349,
0.18371832370758057,
-0.18997526168823242,
-0.5989612340927124,
-0.3028833866119385,
-0.019395919516682625,
-0.01674339734017849,
-0.41504156589508057,
0.14423847198486328,
0.6185741424560547,
0.08835724741220474,
-0.677460789680481,
-0.12058842927217484,
-0.3938813805580139,
-0.41946086287498474,
0.38017845153808594,
-0.23686449229717255,
-0.035938311368227005,
-0.0007971189334057271,
-0.44951745867729187,
0.257612943649292,
0.19982264935970306,
0.019240662455558777,
-0.23535868525505066,
0.07793831080198288,
-0.32557129859924316,
0.2968789339065552,
-0.05201607570052147,
0.23232583701610565,
-0.06651592254638672,
0.8164588212966919,
-0.0004068808048032224,
-0.18580535054206848,
-0.21704763174057007,
0.2718265652656555,
0.3884757161140442,
-0.5413721799850464,
-0.41387832164764404,
0.47800374031066895,
0.27189144492149353,
-0.28973639011383057,
-0.10993519425392151,
0.07090134918689728,
0.02550899051129818,
0.0010176928481087089,
-0.11778706312179565,
0.0197176281362772,
0.24409446120262146,
0.3742729127407074,
-0.1330617219209671,
-0.4965381920337677,
-0.23606188595294952,
-0.4788628816604614,
0.10524094104766846,
0.48074033856391907,
-0.33690887689590454,
-0.5862573981285095,
0.6209220886230469,
-0.6060609221458435,
0.40661224722862244,
0.10790321975946426,
0.27782824635505676,
-0.1647426038980484,
0.48948153853416443,
-0.5298575162887573,
-0.10197988152503967,
0.13894988596439362,
0.24194428324699402,
0.10230321437120438,
0.19002507627010345,
-0.08646516501903534,
0.2784164845943451,
-0.0899227038025856,
0.13936881721019745,
-0.3899860680103302,
0.2823513448238373,
-0.539336621761322,
-0.2868218421936035,
-0.057313162833452225,
-0.175147145986557,
0.0216575488448143,
-0.4054781198501587,
0.10564322769641876,
-0.35316377878189087,
0.10522444546222687,
0.2962788939476013,
0.3424670398235321,
-0.3140140175819397,
0.11745251715183258,
0.34211334586143494,
0.382202684879303,
0.32051563262939453,
-0.7600204348564148,
-0.1789804846048355,
-0.06312369555234909,
0.3228502571582794,
-0.176608607172966,
-0.142264723777771,
0.228346049785614,
-0.09532800316810608,
-0.25445756316185,
0.28644490242004395,
0.7686834335327148,
-0.3275831341743469,
-0.4317326545715332,
-0.04346093907952309,
-0.047055765986442566,
0.5886276364326477,
0.44769951701164246,
-0.23769517242908478,
0.3352248966693878,
0.4793975353240967,
-0.33462318778038025,
-0.17305557429790497,
0.5041391849517822,
0.15389908850193024,
0.6358160972595215,
0.011391153559088707,
0.34401604533195496,
1.0138834714889526,
0.7561554908752441,
0.3464484214782715,
0.045725345611572266,
0.047293297946453094,
-0.20776119828224182,
0.13067974150180817,
-0.23665140569210052,
-0.021349720656871796,
0.0007079922361299396,
0.5371043086051941,
-0.10986462235450745,
0.006204507779330015,
0.06801897287368774,
-0.0673951655626297,
0.4909290671348572,
0.4524765908718109,
0.31998035311698914,
-0.1858016699552536,
-0.11528673768043518,
0.359756737947464,
0.0662451833486557,
0.37262678146362305,
0.23535634577274323,
-0.034049201756715775,
-0.7223083972930908,
0.2070380598306656,
-0.32919543981552124,
-0.2008523941040039,
0.2927744388580322,
-0.040096819400787354,
0.44855377078056335,
-0.003231111913919449,
-0.03343658894300461,
-0.25439831614494324,
0.03838525339961052,
0.8919640779495239,
-0.4082450270652771,
0.19840428233146667,
0.13182432949543,
-0.24362996220588684,
0.667415976524353,
-0.15632089972496033,
0.7019478678703308,
-0.25682932138442993,
-0.5248136520385742,
0.9407007098197937,
0.05817205831408501,
0.6156662702560425,
0.039499685168266296,
0.25216004252433777,
-0.17857158184051514,
-0.20231589674949646,
-0.5944845080375671,
-0.02611236460506916,
0.19817815721035004,
0.20816512405872345,
0.23242232203483582,
-0.15048018097877502,
0.40114253759384155,
-0.5915970206260681,
-0.6462240219116211,
-0.11412135511636734,
-0.06233644485473633,
-0.5138946175575256,
0.0015626732492819428,
-0.2609277665615082,
0.2566809356212616,
0.2642873227596283,
-0.06810648739337921,
-0.3146968185901642,
0.5604274272918701,
-0.006159370299428701,
-0.06212982162833214,
-0.43086713552474976,
0.6189314126968384,
-0.19498211145401,
-0.28555071353912354,
-0.2211427390575409,
0.026125852018594742,
0.5128130912780762,
0.1574733406305313,
-0.07762256264686584,
-0.1097448393702507,
-0.04043474420905113,
0.19724154472351074,
-0.1704212874174118,
0.04884142428636551,
0.13403654098510742,
-0.4538463354110718,
-0.2712844908237457,
0.17301201820373535,
0.3820474445819855,
-0.4585210680961609,
-0.03443833068013191,
-0.4211218059062958,
0.14168137311935425,
0.005828124936670065,
-0.031755782663822174,
0.51530921459198,
-0.13715223968029022,
0.03784855827689171,
-0.15686634182929993,
0.02150856703519821,
-0.15680469572544098,
-0.08852799236774445,
-0.12184860557317734,
-0.08123933523893356,
0.3156561255455017,
-0.10195859521627426,
-0.12493794411420822,
0.16365276277065277,
-0.22207790613174438,
0.504569947719574,
0.13331545889377594,
0.22053958475589752,
-0.6197996735572815,
-0.6692101359367371,
-0.5123911499977112,
0.03954535350203514,
-0.2658567726612091,
-0.10818830877542496,
-0.2129320502281189,
-0.3201012909412384,
-0.1949731409549713,
-0.23531125485897064,
-0.059081096202135086,
-0.36898282170295715,
-0.06992083042860031,
-0.13960514962673187
] |
In February 2015 the National Institute for Health and Care Excellence (NICE) published new guidance (NG3) on the management of diabetes in pregnancy. Care teams need to be aware of this guidance and implement its recommendations. These include preconception care with target HbA1c 48 mmol/mol. Women at risk of gestational diabetes mellitus (GDM) should have a 75 g oral glucose tolerance test (OGTT). Diagnostic criteria for GDM have changed to fasting glucose of 5.6 mmol/L or above or 2 hour glucose of 7.8 mmol/L or above. Glycaemic targets in all diabetic pregnancies have changed to fasting glucose below 5.3 mmol/L (4–5.2 mmol/L if on insulin) and 1 hour postprandial glucose below 7.8 mmol/L if these can be achieved safely. Continuous glucose monitoring and insulin pump therapy should not be used routinely but can be used if glycaemic control is problematic. Capillary ketone testing should be routine for women with type 1 diabetes when hyperglycaemic and for all women with diabetes including, GDM when acutely unwell. More flexibility is offered around recommended delivery timing: 37+0 weeks to 38+6 weeks for women with types 1 and 2 diabetes; prior to 40+6 in GDM (and earlier if complications arise). Postnatal testing following GSM should be by fasting glucose (not OGTT) at 6–13 weeks post partum. Testing later than this can use HbA1c. Introducing these changes will have resource implications, including a likely increase in the number of women diagnosed with GDM. | [
-0.02362200990319252,
0.002599235624074936,
-0.017789756879210472,
-0.0008741382043808699,
0.0177163016051054,
0.023355625569820404,
0.009890146553516388,
-0.004922144114971161,
-0.0073153311386704445,
-0.025896141305565834,
-0.0017194747924804688,
-0.004239540547132492,
0.005757190752774477,
0.00765952980145812,
-0.011992902494966984,
-0.01361148338764906,
-0.026404278352856636,
-0.005353475920855999,
0.010392000898718834,
0.010348876938223839,
0.014818459749221802,
-0.016375672072172165,
0.009880106896162033,
0.028490005061030388,
-0.002052015159279108,
0.019573790952563286,
0.009295949712395668,
-0.025471316650509834,
0.005444454960525036,
0.003732134122401476,
0.0018431744538247585,
0.01013777032494545,
0.014113422483205795,
-0.013696460984647274,
0.004046426620334387,
-0.018208114430308342,
-0.006742444820702076,
0.018909655511379242,
-0.015787653625011444,
-0.0038118120282888412,
0.01072784885764122,
-0.015431076288223267,
0.004789548926055431,
0.002580218482762575,
-0.008054463192820549,
-0.017370931804180145,
-0.008406588807702065,
-0.011886750347912312,
0.006018206011503935,
0.013640828430652618,
-0.008267069235444069,
-0.03129615634679794,
-0.003445066511631012,
-0.005172113887965679,
-0.005482306703925133,
0.013480059802532196,
0.017396993935108185,
0.004910165444016457,
-0.0176854208111763,
0.02319171652197838,
-0.001457978505641222,
-0.013082632794976234,
0.011927496641874313,
-0.015606031753122807,
-0.005314038135111332,
-0.0669349730014801,
0.02634740248322487,
-0.02540506422519684,
-0.01607648655772209,
0.04021155834197998,
-0.013292745687067509,
0.0050867777317762375,
0.02158173732459545,
0.010491025634109974,
-0.018168995156884193,
-0.006592501420527697,
-0.006589655764400959,
0.03419911861419678,
0.0008270330727100372,
-0.003500943072140217,
-0.011880660429596901,
-0.01369071938097477,
-0.02179267816245556,
0.012252476066350937,
0.0018425150774419308,
-0.015056265518069267,
-0.0012844938319176435,
-0.023386448621749878,
-0.012205472216010094,
0.007541971281170845,
0.01158236525952816,
-0.013964075595140457,
-0.0026166681200265884,
-0.034187160432338715,
-0.04503808915615082,
0.0033243196085095406,
0.005514230579137802,
0.02000248432159424,
0.003440449945628643,
0.0009455885738134384,
-0.007589038461446762,
0.008406227454543114,
0.002507413737475872,
-0.014445625245571136,
0.009555812925100327,
0.0032902327366173267,
0.025829318910837173,
0.0016822803299874067,
-0.017193321138620377,
0.003146169241517782,
-0.000981628429144621,
0.014314606785774231,
0.0014947769232094288,
0.01692846417427063,
0.013354017399251461,
0.01959741860628128,
-0.002967819571495056,
-0.0009500996675342321,
-0.0038689500652253628,
0.001072377897799015,
-0.011185290291905403,
0.008768237195909023,
-0.0064467075280845165,
0.0028263162821531296,
-0.0007230459596030414,
-0.008120004087686539,
0.012355022132396698,
-0.00489223375916481,
-0.011121505871415138,
-0.009502445347607136,
-0.006341537926346064,
-0.003958949353545904,
-0.008619756437838078,
-0.019590670242905617,
-0.003932685125619173,
0.006531530525535345,
-0.01822679489850998,
0.007695426233112812,
0.004242277704179287,
0.0007390580140054226,
0.01216939091682434,
0.00793682411313057,
0.0045490143820643425,
-0.0009006289765238762,
0.0039682816714048386,
-0.006219194270670414,
-0.027490664273500443,
-0.010072069242596626,
-0.0047568813897669315,
-0.025438055396080017,
-0.022441240027546883,
-0.01658550277352333,
-0.014793277718126774,
-0.01158248633146286,
0.015553543344140053,
-0.02616814710199833,
-0.020086107775568962,
-0.011300496757030487,
-0.009226755239069462,
0.012689629569649696,
0.022915014997124672,
-0.011358529329299927,
-0.0014094752259552479,
0.009632592089474201,
-0.014389940537512302,
0.02430322766304016,
-0.026040740311145782,
0.0001130267046391964,
-0.008456617593765259,
0.00818849541246891,
-0.01590033806860447,
-0.014805403538048267,
0.013902116566896439,
-0.0006595724844373763,
-0.01683560200035572,
-0.005006991792470217,
-0.01535799540579319,
0.005096797831356525,
0.006296704988926649,
0.06648118793964386,
-0.004659954458475113,
-0.011847767978906631,
-0.008082193322479725,
0.007833389565348625,
0.02034122124314308,
-0.004131196532398462,
0.014674574136734009,
-0.023411717265844345,
-0.026403842493891716,
0.03557915240526199,
-0.008376521058380604,
0.011597251519560814,
-0.013591275550425053,
0.008014372549951077,
-0.01081564836204052,
0.0026727640070021152,
-0.012154724448919296,
-0.0013907254906371236,
0.009325655177235603,
-0.0025591738522052765,
0.005929083097726107,
0.008052986115217209,
0.016961902379989624,
0.016499768942594528,
0.0087151899933815,
0.012862661853432655,
-0.013302887789905071,
-0.01092434674501419,
0.013140179216861725,
-0.006679971236735582,
0.029332946985960007,
-0.019635606557130814,
-0.0020581535063683987,
-0.0034007192589342594,
-0.009165208786725998,
-0.018067723140120506,
-0.02127005159854889,
-0.021916888654232025,
-0.016999103128910065,
-0.008507389575242996,
0.007466618902981281,
0.004563110414892435,
-0.020428039133548737,
-0.0051865410059690475,
0.03950216993689537,
-0.02267773635685444,
-0.016760047525167465,
0.006238108966499567,
-0.016051162034273148,
0.015896806493401527,
0.0043837144039571285,
-0.013452795334160328,
-0.010451920330524445,
0.028838250786066055,
-0.016026001423597336,
0.0010590143501758575,
0.009820858016610146,
-0.0014066137373447418,
0.009196577593684196,
-0.017111413180828094,
-0.02028941735625267,
-0.026781853288412094,
0.020361939445137978,
0.0027820668183267117,
-0.00945570319890976,
0.011893612332642078,
-0.0230424702167511,
0.03144175559282303,
-0.030595343559980392,
0.011396537534892559,
0.009513771161437035,
0.012697464786469936,
0.0327589176595211,
-0.012213488109409809,
0.02331526204943657,
-0.0166596882045269,
0.02325506880879402,
-0.0009005760657601058,
0.02448071539402008,
-0.01199637446552515,
0.00592497643083334,
0.011639067903161049,
-0.0019886214286088943,
0.013418045826256275,
-0.02386527508497238,
0.013862524181604385,
0.012466471642255783,
0.005825298838317394,
0.010230131447315216,
0.01406942494213581,
0.0053015234880149364,
-0.0029581962153315544,
-0.010773069225251675,
-0.08149038255214691,
-0.016361054033041,
0.012996106408536434,
0.005194057244807482,
0.00528751639649272,
0.013401011005043983,
0.014127974398434162,
-0.002096455777063966,
-0.006771150976419449,
-0.022592902183532715,
0.017357107251882553,
-0.0008175172843039036,
-0.00654511246830225,
0.022905472666025162,
0.012414408847689629,
-0.0019302982836961746,
-0.0015879401471465826,
-0.003807355184108019,
-0.005324149038642645,
-0.01914389431476593,
0.022014331072568893,
0.012531358748674393,
0.02660030871629715,
-0.010082371532917023,
0.012076305225491524,
-0.0044009266421198845,
0.0028589561115950346,
-0.019556384533643723,
-0.03070972114801407,
0.005686039570719004,
0.006153050810098648,
-0.021352918818593025,
0.013423225842416286,
-0.002176931593567133,
-0.006336155813187361,
-0.018959466367959976,
-0.009721465408802032,
-0.006201552227139473,
-0.004309789277613163,
-0.008045630529522896,
-0.012205327861011028,
0.00568818487226963,
-0.011440996080636978,
-0.016798902302980423,
0.0034898058511316776,
0.02049095928668976,
0.0030801629181951284,
0.010635776445269585,
0.02044319361448288,
0.006762950215488672,
0.03796083480119705,
-0.0012262910604476929,
0.024305051192641258,
0.008779401890933514,
-0.017185157164931297,
-0.0024482347071170807,
0.0048387860879302025,
0.00439192820340395,
-0.006346115842461586,
-0.0262908972799778,
0.01805446296930313,
0.008093002252280712,
-0.026703590527176857,
0.006792994681745768,
-0.013096612878143787,
-0.0012966325739398599,
0.011310677975416183,
0.00020704115740954876,
-0.008600007742643356,
-0.0158078670501709,
-0.000416747760027647,
-0.007122288923710585,
-0.01767822727560997,
-0.0008738656179048121,
-0.02086927741765976,
-0.01137192640453577,
-0.0149722034111619,
-0.016241485252976418,
0.017745042219758034,
0.013721095398068428,
-0.020022345706820488,
0.013406883925199509,
-0.0234205462038517,
-0.009890565648674965,
-0.007350906729698181,
0.006787681020796299,
0.002837149892002344,
0.0029006279073655605,
0.013744093477725983,
-0.007966449484229088,
-0.02533671073615551,
0.01790645904839039,
-0.021161219105124474,
0.005821431986987591,
0.013049975037574768,
0.012601479887962341,
0.002867175033316016,
-0.0011792303994297981,
0.029691677540540695,
0.00763749098405242,
-0.001666718628257513,
-0.00418725423514843,
-0.004341838415712118,
-0.01733105629682541,
0.000022291205823421478,
0.012629637494683266,
0.011076495051383972,
0.005610776133835316,
-0.008149750530719757,
-0.007016686722636223,
0.010049613192677498,
-0.0037983604706823826,
-0.007272561080753803,
0.006976286415010691,
0.00267006061039865,
0.007108347490429878,
-0.0007609454914927483,
0.014536060392856598,
0.07266999781131744,
-0.008311497047543526,
0.008250025101006031,
-0.01947309449315071,
0.012049153447151184,
-0.009608740918338299,
-0.0004825158976018429,
0.017840314656496048,
0.010665953159332275,
0.02896314114332199,
0.012598183006048203,
0.0008613972458988428,
-0.009045197628438473,
0.014716144651174545,
-0.018255338072776794,
0.011356552131474018,
0.014233056455850601,
0.012400977313518524,
0.003934191539883614,
-0.014532291330397129,
0.009957593865692616,
0.011427696794271469,
-0.02595629170536995,
0.0011530457995831966,
0.003522614948451519,
-0.010785337537527084,
-0.025804026052355766,
-0.012960647232830524,
0.0026700678281486034,
0.007185721304267645,
-0.0007101204246282578,
0.03242304176092148,
-0.007787913084030151,
0.0036256867460906506,
0.0011213000398129225,
0.0036197034642100334,
0.019490372389554977,
0.03338482975959778,
0.02416631393134594,
-0.009078223258256912,
0.0035924999974668026,
-0.017942698672413826,
0.0035504193510860205,
-0.00634125666692853,
-0.004433791618794203,
-0.0015437715919688344,
-0.006828931625932455,
-0.00775824673473835,
-0.006391073111444712,
0.021413415670394897,
-0.005142030771821737,
0.004681616090238094,
0.008198129013180733,
0.019807379692792892,
-0.02139946259558201,
-0.021866165101528168,
0.003900783369317651,
-0.017270809039473534,
-0.015394678339362144,
-0.007200335152447224,
-0.0049230800941586494,
0.010277556255459785,
0.01691444404423237,
0.000223538838326931,
0.006360506173223257,
-0.009146828204393387,
0.004962312523275614,
0.002536690328270197,
0.022985465824604034,
-0.005177742801606655,
0.007030936423689127,
-0.007012395653873682,
0.020250990986824036,
-0.007797300349920988,
-0.008476654067635536,
0.0011141716968268156,
0.011814018711447716,
-0.024993877857923508,
-0.00796015840023756,
-0.011920176446437836,
-0.02093885838985443,
-0.018664736300706863,
-0.0077175782062113285,
-0.0053723836317658424,
0.017502106726169586,
0.02545243874192238,
0.028285644948482513,
-0.07509627193212509,
0.014993870630860329,
0.010055450722575188,
-0.016006555408239365,
0.0030104147735983133,
-0.003821225371211767,
-0.024143368005752563,
0.004307880997657776,
-0.00469623040407896,
-0.010604552924633026,
0.03282926604151726,
-0.029315680265426636,
-0.011506985872983932,
-0.014274819754064083,
0.011846163310110569,
0.03356807678937912,
-0.01819765567779541,
-0.010954449884593487,
-0.019129320979118347,
0.0253603495657444,
0.005881770513951778,
-0.0036322642117738724,
-0.0340120866894722,
-0.013411829248070717,
-0.0034238649532198906,
-0.08186905086040497,
0.003936270251870155,
0.0018049248028546572,
0.010241074487566948,
-0.015332087874412537,
-0.008972383104264736,
0.014438875019550323,
0.003500628750771284,
0.009447296150028706,
-0.013272983022034168,
0.007519491948187351,
0.0034037730656564236,
0.03432869538664818,
-0.007429045625030994,
0.0075704073533415794,
-0.002417690120637417,
0.01168258860707283,
0.03324081748723984,
0.005714970640838146,
0.0031223020050674677,
-0.02681228332221508,
0.0058092521503567696,
-0.006293146871030331,
-0.004093291237950325,
-0.012756473384797573,
0.03308838605880737,
-0.029692502692341805,
0.013715204782783985,
0.014312533661723137,
0.0049787843599915504,
0.014385613612830639,
-0.02529911696910858,
-0.014367210678756237,
-0.0024728868156671524,
-0.0010765709448605776,
-0.0006164825172163546,
-0.012518022209405899,
-0.0369499996304512,
0.03339863568544388,
-0.003163585439324379,
0.001363122253678739,
0.0034654848277568817,
-0.03910471126437187,
0.029929453507065773,
0.004541683942079544,
0.03532388061285019,
0.0065855165012180805,
-0.007393908221274614,
-0.00855511985719204,
0.006752649787813425,
0.012423492968082428,
-0.006818145979195833,
0.017835717648267746,
-0.02132449857890606,
-0.028149055317044258,
0.002270009135827422,
-0.011260821484029293,
0.02572137489914894,
-0.003479295875877142,
-0.003146891249343753,
-0.014286543242633343,
0.025467127561569214,
0.02892393246293068,
0.07177523523569107,
-0.02095351740717888,
-0.020829686895012856,
0.015237290412187576,
-0.009457345120608807,
0.003625199431553483,
0.006905757822096348,
-0.01012209802865982,
-0.016031529754400253,
0.02082551270723343,
0.003237505443394184,
0.0034196479246020317,
-0.013384967111051083,
0.014074436388909817,
-0.004548028111457825,
0.006419700104743242,
-0.0038464097306132317,
0.015849493443965912,
-0.01791113056242466,
0.015376918017864227,
0.02673199400305748,
0.017091184854507446,
-0.01377507857978344,
-0.01799778640270233,
0.0187277402728796,
-0.017933502793312073,
0.008306166157126427,
-0.012583896517753601,
-0.03955540060997009,
0.021200431510806084,
-0.005535941570997238,
0.010093772783875465,
0.00539256539195776,
0.0017016921192407608,
0.009589679539203644,
0.014567822217941284,
0.02647874504327774,
0.00903063453733921,
0.006117906421422958,
-0.010902954265475273,
-0.010184203274548054,
-0.018977027386426926,
-0.003411499783396721,
-0.004017811268568039,
0.00424492871388793,
-0.009427529759705067,
-0.016364093869924545,
0.0027384760323911905,
-0.008503273129463196,
0.005446309689432383,
-0.007956958375871181,
0.0014709563693031669,
0.00909043475985527,
-0.005743100307881832,
0.011713250540196896,
-0.004681120160967112,
-0.021741610020399094,
0.007144675590097904,
-0.017469050362706184,
0.0019395649433135986,
0.008651548996567726,
-0.028551846742630005,
0.028715698048472404,
0.0007632671622559428,
0.015468105673789978,
-0.012508207000792027,
0.015709344297647476,
-0.01667426899075508,
0.015463393181562424,
0.008622845634818077,
0.005507718306034803,
-0.0012484868057072163,
0.010665602050721645,
0.007404777221381664,
0.01070867758244276,
0.0019346794579178095,
-0.035420872271060944,
-0.0032019191421568394,
0.011022338643670082,
0.010191546753048897,
-0.009861696511507034,
-0.0220820102840662,
0.02338418737053871,
0.01583079621195793,
0.020581087097525597,
0.025679539889097214,
0.004675735253840685,
0.012178060598671436,
-0.009246828965842724,
0.004904669709503651,
-0.006913144141435623,
0.0010202222038060427,
-0.00010986410779878497,
-0.007104520220309496,
0.0009755878709256649,
0.034120216965675354,
-0.0014081853441894054,
0.008304314687848091,
0.0122562600299716,
0.0031597104389220476,
0.02640824392437935,
-0.01489340327680111,
-0.009447888471186161,
0.03418731689453125,
-0.006651895586401224,
0.005737193860113621,
0.026571009308099747,
-0.022751733660697937,
0.01916227862238884,
0.0211898535490036,
-0.02262718230485916,
-0.0157649964094162,
0.010013997554779053,
0.02841772884130478,
-0.0031711815390735865,
-0.010257646441459656,
-0.005252251401543617,
0.011907740496098995,
0.020464196801185608,
-0.005909139756113291,
0.01852346770465374,
0.0022864816710352898,
-0.01989908516407013,
0.030562851577997208,
0.005199636332690716,
0.012740563601255417,
-0.012110468000173569,
0.017503712326288223,
0.009259924292564392,
-0.0004671011120080948,
0.024643708020448685,
0.0015029112109914422,
0.0144943343475461,
0.020072627812623978,
0.0049932715483009815,
-0.014625897631049156,
-0.013405406847596169,
0.005352017469704151,
-0.007958399131894112,
-0.0030789198353886604,
-0.020925376564264297,
0.014264345169067383,
0.006781379692256451,
-0.014066159725189209,
0.007570239715278149,
0.0023276028223335743,
-0.0038195194210857153,
0.045425619930028915,
0.004261782858520746,
0.0035287572536617517,
0.004486531484872103,
0.014031734317541122,
-0.006978223100304604,
-0.004120179917663336,
-0.01974349468946457,
0.022403551265597343,
-0.012062085792422295,
-0.005157649051398039,
-0.025365184992551804,
-0.0002276435261592269,
-0.0006651881849393249,
0.0024732891470193863,
0.017001479864120483,
0.006432490423321724,
0.004226180724799633,
0.03821256011724472,
0.015910012647509575,
-0.002064830856397748,
-0.020283162593841553,
-0.035361625254154205,
0.0031247951555997133,
-0.0033845831640064716,
-0.003399520181119442,
0.016097158193588257,
-0.014753698371350765,
0.013115466572344303,
0.0032810664270073175,
-0.00426733773201704,
-0.007957330904901028,
0.030216224491596222,
-0.002853638958185911,
-0.012786807492375374,
-0.0055374763906002045,
-0.01488335058093071,
0.006708559114485979,
0.0044485824182629585,
0.007714095991104841,
-0.009162208065390587,
0.008768898434937,
-0.014889601618051529,
-0.0031965046655386686,
-0.03747697174549103,
-0.017696011811494827,
-0.010146011598408222,
0.02250603213906288,
0.017105568200349808,
0.03377620875835419,
-0.02788398042321205,
0.004494305234402418,
-0.0047864108346402645,
-0.014701541513204575,
0.008724663406610489
] | [
-0.36188164353370667,
-0.2362741231918335,
0.3286804258823395,
0.05732573941349983,
-0.030840570107102394,
0.5294381380081177,
0.3445277214050293,
-0.07834193110466003,
-0.3826254904270172,
-0.07775581628084183,
0.09273646771907806,
0.6108266711235046,
-0.18481875956058502,
-0.2690492272377014,
-0.08606012165546417,
0.5766519904136658,
0.5644406676292419,
0.5084316730499268,
-0.11148048937320709,
-0.8746082186698914,
-0.061424024403095245,
-0.8502035737037659,
0.6372926831245422,
0.12996631860733032,
-0.24250367283821106,
0.2943000793457031,
0.3228733241558075,
0.168628990650177,
0.23131930828094482,
-0.32864561676979065,
0.21276336908340454,
0.5990949869155884,
0.24355649948120117,
0.5329309105873108,
0.6208353638648987,
0.38766682147979736,
0.05731295794248581,
-0.1889912337064743,
-0.027544138953089714,
-0.24430927634239197,
-0.5632290840148926,
-0.022870654240250587,
-0.4680176079273224,
0.1794462651014328,
0.08015155047178268,
-0.24285109341144562,
-1.3021005392074585,
-0.10027619451284409,
-0.21984942257404327,
0.0021889032796025276,
-0.12984886765480042,
0.38359615206718445,
0.5519652962684631,
0.22207657992839813,
0.04356425628066063,
0.23918092250823975,
-0.7699145078659058,
0.044328052550554276,
-0.19857598841190338,
0.22972945868968964,
0.21049626171588898,
-0.4109671711921692,
-0.05043001472949982,
0.051153022795915604,
-0.49497780203819275,
-0.04449567198753357,
-0.05105365440249443,
0.2855786681175232,
0.03786775469779968,
0.055808790028095245,
0.08896190673112869,
-0.5275065302848816,
-0.16000747680664062,
0.4119170904159546,
-0.23063093423843384,
-0.1055670976638794,
-0.22919021546840668,
-0.1700928509235382,
0.6273574233055115,
0.008767286315560341,
0.20739024877548218,
0.19837486743927002,
0.3383570909500122,
0.08630290627479553,
-0.0025157665368169546,
0.8012260794639587,
0.15547215938568115,
0.558060884475708,
0.1440315693616867,
0.7247188091278076,
-0.04137049615383148,
-0.2762194573879242,
0.5630401968955994,
0.05912845581769943,
-0.2470201551914215,
0.07524875551462173,
-0.10288920253515244,
-0.38290196657180786,
0.48836931586265564,
0.027808107435703278,
0.4375731348991394,
-0.25659728050231934,
0.07061303406953812,
-0.10616620630025864,
-0.3318897485733032,
-0.16773563623428345,
-0.10974334180355072,
-0.826120913028717,
0.04550737887620926,
-0.1821405291557312,
-0.4843502938747406,
0.34129610657691956,
-0.1795286387205124,
0.07789649069309235,
-0.2760566174983978,
0.4698013365268707,
-0.1942209005355835,
-0.048307839781045914,
-0.128719761967659,
0.19026319682598114,
-0.16167959570884705,
0.060907136648893356,
0.36087602376937866,
0.15156057476997375,
0.32751888036727905,
0.27867555618286133,
0.5361616015434265,
0.3449022173881531,
0.06731701642274857,
0.7033517956733704,
-0.11899080127477646,
0.21902847290039062,
-0.08067405223846436,
-0.7414342761039734,
-0.043885618448257446,
-0.2243751734495163,
-0.13887548446655273,
-0.10234899818897247,
0.26785650849342346,
0.4828721880912781,
0.02473563887178898,
-0.24032101035118103,
-0.0047872127033770084,
-0.3673988878726959,
0.5644595623016357,
-0.2748173177242279,
-0.2709656059741974,
-0.10892470180988312,
-0.5313230156898499,
0.20382829010486603,
-0.2958563268184662,
-0.31028395891189575,
-0.24306613206863403,
0.002099111210554838,
0.14137807488441467,
0.1369050145149231,
-0.7725343704223633,
0.00302074640057981,
-0.22736398875713348,
-0.09353471547365189,
0.24516580998897552,
0.09366188198328018,
-0.5664709210395813,
-0.02124972827732563,
0.39719638228416443,
-0.11619752645492554,
0.6072500348091125,
0.2161533385515213,
0.11787839978933334,
0.1275932341814041,
-0.3190372884273529,
-0.32369330525398254,
-0.5459315180778503,
-0.2702564597129822,
-0.45525243878364563,
0.2781587839126587,
0.36277440190315247,
0.4815824031829834,
-0.09613620489835739,
0.16788813471794128,
-0.7976968288421631,
0.1545618772506714,
0.654477059841156,
-0.18241868913173676,
0.2204565703868866,
0.015401264652609825,
0.7672073841094971,
-0.36037322878837585,
-0.19013726711273193,
-0.027187246829271317,
-0.3341986835002899,
0.18233655393123627,
0.9599239230155945,
-0.8987074494361877,
1.2345846891403198,
-0.5661342144012451,
0.12348192185163498,
0.9621682167053223,
-0.15887556970119476,
-0.06980627775192261,
0.018285218626260757,
0.20188365876674652,
0.33524927496910095,
-0.44264650344848633,
-0.7756693959236145,
0.18725703656673431,
-0.11174806207418442,
-0.35137322545051575,
-0.16967210173606873,
0.11211356520652771,
0.38872119784355164,
-0.4846210777759552,
-0.21156920492649078,
-0.08766167610883713,
-0.00916371215134859,
-0.420011967420578,
0.36668768525123596,
0.20328928530216217,
0.14504936337471008,
-0.1592545211315155,
0.4081624150276184,
-0.18251056969165802,
0.035532526671886444,
0.36452189087867737,
0.3552539050579071,
0.229159414768219,
0.9648385643959045,
0.6288278698921204,
0.6021471619606018,
-0.4035135507583618,
0.3195534646511078,
-0.27569758892059326,
0.3285021185874939,
0.0856342762708664,
-0.019531888887286186,
0.46373650431632996,
-0.2542736828327179,
-0.4085211753845215,
-0.01702721044421196,
-0.24618127942085266,
0.18483087420463562,
0.3616580665111542,
-0.01039840653538704,
0.42489373683929443,
0.24343392252922058,
-0.27987706661224365,
-0.3713313341140747,
0.5072513818740845,
-0.9870108366012573,
-0.41241949796676636,
0.14074324071407318,
0.4077964425086975,
0.29629677534103394,
-0.04775506630539894,
-0.22359545528888702,
-0.3411030173301697,
-0.2796785831451416,
-0.13599252700805664,
0.554545521736145,
-0.05506212264299393,
0.008149976842105389,
-0.01743633858859539,
0.7254505157470703,
0.36616846919059753,
-0.24793559312820435,
-0.007597571704536676,
-1.086122751235962,
-0.4340119957923889,
-0.21697983145713806,
0.5113903284072876,
0.5703824162483215,
-0.270239919424057,
-0.7267293334007263,
0.016810955479741096,
0.14910154044628143,
-0.8525654077529907,
0.78410404920578,
0.9327061772346497,
-0.7016077041625977,
-0.08987584710121155,
0.015422520227730274,
0.5557951927185059,
0.9029396772384644,
0.20739386975765228,
-0.564297080039978,
-0.25080862641334534,
-0.01452649012207985,
-0.3899458646774292,
-0.249721497297287,
-0.300769567489624,
-0.0919480249285698,
0.7150639891624451,
-0.33540433645248413,
-0.38190725445747375,
0.5258529186248779,
0.37723422050476074,
-0.28136351704597473,
0.5030691027641296,
0.7085494995117188,
0.21307025849819183,
0.2551305890083313,
0.14973479509353638,
0.40753594040870667,
0.012944399379193783,
-0.3536675274372101,
-0.17026586830615997,
-0.0557808019220829,
0.0032071468885987997,
-5.843884468078613,
-0.062034014612436295,
-0.6317124366760254,
-0.78910893201828,
-0.6006168127059937,
-0.22004449367523193,
1.1535975933074951,
-0.1245327889919281,
0.015100325457751751,
0.6650799512863159,
0.17485922574996948,
0.38298729062080383,
0.34317320585250854,
-0.5588406920433044,
-0.09682221710681915,
0.45743709802627563,
0.25139743089675903,
-0.41990628838539124,
0.23355825245380402,
0.27470800280570984,
0.7801035642623901,
-0.3594421446323395,
0.020602863281965256,
0.36712270975112915,
0.19112460315227509,
-0.25342458486557007,
-0.6462873816490173,
0.4201657474040985,
-0.28964823484420776,
-0.1793076992034912,
0.39015135169029236,
-0.3138960301876068,
-0.04816199839115143,
-0.4550890326499939,
0.6730343103408813,
0.16371995210647583,
0.16202455759048462,
0.23785360157489777,
-0.08659596741199493,
-0.21314235031604767,
0.503006637096405,
0.29146069288253784,
-0.010868014767765999,
-0.1681925654411316,
0.48646387457847595,
0.28289660811424255,
0.24960742890834808,
-0.006135893519967794,
-0.2806070148944855,
0.6185073852539062,
0.11431847512722015,
-0.49203917384147644,
-0.3534526824951172,
0.0011413090396672487,
0.12486769258975983,
0.1605287343263626,
-0.17576271295547485,
0.09260191023349762,
-0.2632066309452057,
0.21425603330135345,
-0.3869076073169708,
-0.039570678025484085,
-0.24693197011947632,
-0.5731877088546753,
-0.14352986216545105,
0.23970820009708405,
-1.057466983795166,
-0.29235967993736267,
0.11632625013589859,
0.25849565863609314,
-0.6650431156158447,
-0.028691545128822327,
0.46923837065696716,
-0.7589098811149597,
0.24934269487857819,
-0.6624254584312439,
0.37748610973358154,
0.2987852096557617,
-0.4661150872707367,
-0.16344326734542847,
0.06580833345651627,
-0.42524081468582153,
0.18830478191375732,
0.4011595547199249,
0.7017830610275269,
-0.3680204749107361,
-0.385933518409729,
-0.5131747722625732,
0.06946717947721481,
0.05661636218428612,
0.36553630232810974,
-0.3791898787021637,
-0.01834402233362198,
0.5885788202285767,
0.09023348242044449,
-0.10763225704431534,
0.13891474902629852,
0.4351142942905426,
-0.18218554556369781,
-0.43405741453170776,
0.09982813894748688,
0.1875118613243103,
-0.008338943123817444,
-0.9888230562210083,
-0.11694548279047012,
0.29011115431785583,
-0.2975548803806305,
-0.031621210277080536,
0.2759717106819153,
-0.856327474117279,
0.029623372480273247,
0.01915370672941208,
-0.2716275155544281,
-0.3492298722267151,
0.22013182938098907,
-0.30454370379447937,
-0.18960104882717133,
-0.14416372776031494,
0.3668542206287384,
-0.07604017108678818,
-0.30577465891838074,
0.20339611172676086,
-0.12326961755752563,
-0.24923883378505707,
0.0962153971195221,
-0.3120858371257782,
0.24380247294902802,
0.49491187930107117,
-0.33119696378707886,
0.36636900901794434,
0.09434942156076431,
0.5073130130767822,
0.02364993654191494,
0.0908329039812088,
0.04789448156952858,
-0.6458152532577515,
-0.6053672432899475,
0.8064600825309753,
0.09357964992523193,
-0.1091155931353569,
-0.02260904386639595,
0.38384392857551575,
-0.3843928575515747,
-0.09837093949317932,
0.08594373613595963,
0.09738921374082565,
0.28726866841316223,
0.20654848217964172,
-0.5965386629104614,
-0.0398084931075573,
0.48949742317199707,
-0.21491387486457825,
0.16353724896907806,
0.07535164058208466,
-0.33506929874420166,
0.5328962802886963,
0.5177829265594482,
0.6579813957214355,
-0.15555882453918457,
-0.8795938491821289,
0.16939309239387512,
-0.1695965677499771,
-1.184749960899353,
-0.43565884232521057,
0.14646273851394653,
0.31322330236434937,
0.22211027145385742,
-0.28632852435112,
0.03740803524851799,
-0.03825857862830162,
0.2325487732887268,
-0.7091343402862549,
-0.5799983143806458,
0.024244118481874466,
0.08485580235719681,
0.13474689424037933,
-0.0713881403207779,
-0.19990547001361847,
-0.15827268362045288,
0.1285093128681183,
-0.08463940024375916,
-0.8379882574081421,
0.01744399033486843,
0.1270928978919983,
0.38945916295051575,
-0.009691532701253891,
0.22979089617729187,
-0.34551578760147095,
-0.16885684430599213,
-0.1693286895751953,
0.7356682419776917,
-0.21959415078163147,
0.529170572757721,
-0.40790295600891113,
0.35493984818458557,
-0.4962598979473114,
0.15875956416130066,
0.6177586913108826,
-0.06053837388753891,
-0.20699070394039154,
-0.34697195887565613,
0.3861154019832611,
-0.48002946376800537,
0.39215317368507385,
0.7129966020584106,
-0.0634850412607193,
-0.43837618827819824,
0.25866201519966125,
-0.6081191301345825,
-0.2954423725605011,
-0.32897230982780457,
-0.4427850544452667,
0.3239005506038666,
0.3735305666923523,
-0.18232221901416779,
0.48492830991744995,
-0.09732858836650848,
-0.3079671561717987,
-0.1536618024110794,
-0.07809527218341827,
0.14840775728225708,
-0.14370976388454437,
-0.6279411911964417,
-0.23541660606861115,
0.10185950994491577,
0.33566343784332275,
0.8265672922134399,
-0.8469754457473755,
0.475359708070755,
0.18802675604820251,
-0.650460958480835,
-0.0756874829530716,
-0.09154734015464783,
0.306082159280777,
-0.5359315872192383,
0.16211174428462982,
-0.5571081638336182,
0.3940156400203705,
0.2798892855644226,
0.4255579710006714,
-0.41049230098724365,
0.8752391934394836,
-0.07500751316547394,
-0.3789448142051697,
-0.5203493237495422,
0.3103317320346832,
0.04205469414591789,
-0.5885092616081238,
-0.39444804191589355,
0.4656554162502289,
0.03131480887532234,
-0.11244797706604004,
0.6219241619110107,
-0.06285025179386139,
0.36869677901268005,
-0.07845417410135269,
-0.19874800741672516,
-0.506930410861969,
0.15319626033306122,
0.1948031187057495,
0.09320386499166489,
0.1724022924900055,
-0.2732158303260803,
0.012711684219539165,
0.1884838491678238,
0.6130581498146057,
-0.2020265907049179,
-0.6878583431243896,
0.08610764890909195,
-0.1254669576883316,
0.13815246522426605,
-0.43944141268730164,
0.11885625869035721,
0.44524693489074707,
0.005487910937517881,
0.24521876871585846,
-0.32176607847213745,
-0.3891580104827881,
-0.021407965570688248,
0.2592597007751465,
-0.21987460553646088,
-0.42854902148246765,
0.31117331981658936,
-0.23525048792362213,
0.6073883771896362,
-0.556675374507904,
0.2022392302751541,
-0.3445534110069275,
-0.3763502240180969,
0.22510971128940582,
0.027912795543670654,
0.3353854715824127,
-0.7660597562789917,
-0.27836892008781433,
-0.28577369451522827,
0.44331619143486023,
0.30981242656707764,
0.2074006050825119,
-0.2969345152378082,
-0.6918032765388489,
0.028142744675278664,
0.7577289938926697,
0.592260479927063,
-0.09005579352378845,
-0.35466212034225464,
0.06438716500997543,
-0.22828295826911926,
-0.39503151178359985,
-0.10634181648492813,
0.19147031009197235,
-0.15715628862380981,
0.305998295545578,
0.5660943388938904,
0.9654726386070251,
-0.32440367341041565,
-0.1743774265050888,
-0.31332024931907654,
0.34097766876220703,
0.0634264349937439,
0.4505597651004791,
0.346335232257843,
0.5821964144706726,
0.5413917899131775,
-0.3282829225063324,
-0.4663299024105072,
0.4047604203224182,
0.4807078540325165,
0.43265342712402344,
0.039300136268138885,
0.791861891746521,
0.3645295798778534,
0.1807275116443634,
-0.0899096131324768,
0.6377390623092651,
0.2912091016769409,
0.49983280897140503,
0.14019204676151276,
-0.5173314213752747,
-0.6963027119636536,
-0.08301138877868652,
1.3321847915649414,
0.12391792237758636,
-0.29179704189300537,
0.29731786251068115,
0.1743001788854599,
0.4961850345134735,
0.15526658296585083,
0.06673677265644073,
0.016517704352736473,
-0.46082162857055664,
0.2737594246864319,
0.027401046827435493,
-0.1921619027853012,
0.14380976557731628,
-0.5049514770507812,
0.10667697340250015,
0.09969717264175415,
-0.8460345268249512,
-0.24875487387180328,
0.12758289277553558,
-0.2818906605243683,
-0.07729888707399368,
0.08481833338737488,
0.1703542172908783,
0.344256192445755,
-0.33326464891433716,
0.3228500783443451,
0.23652805387973785,
0.24342115223407745,
0.012497353367507458,
-0.47311997413635254,
0.2025926262140274,
-0.5429672002792358,
-0.024052156135439873,
0.037226125597953796,
-0.36025717854499817,
-0.2558598518371582,
0.2860119342803955,
0.17978103458881378,
0.1704925000667572,
-0.3479965329170227,
0.31055551767349243,
-0.07262048125267029,
-0.665768563747406,
-0.20659519731998444,
-0.12118136882781982,
-0.4240155518054962,
-0.11795269697904587,
-0.1331130862236023,
-0.015811162069439888,
0.009493744932115078,
-0.34824520349502563,
0.22199514508247375,
-0.7167248725891113,
-0.20443731546401978,
-0.24502705037593842,
0.25063925981521606,
0.5470979809761047,
0.6961530447006226,
0.6274720430374146,
-0.2767397463321686,
-0.2346763014793396,
-0.3132481873035431,
0.14273566007614136,
-0.023831844329833984,
0.6516500115394592,
-0.41936975717544556,
0.29511284828186035,
-0.5444421172142029,
-0.28961271047592163,
0.6370689272880554,
0.406054824590683,
-0.2096269428730011,
0.09252066910266876,
0.24118268489837646,
0.25964218378067017,
0.709221363067627,
-0.9180504679679871,
-0.6341642737388611,
-0.9950198531150818,
-0.6204040050506592,
-0.6196288466453552,
0.6629118919372559,
0.146476611495018,
-0.20179738104343414,
-0.03717982396483421,
0.5358075499534607,
0.09306362271308899,
-0.1531897634267807,
0.341259241104126,
-0.5796945691108704,
0.18145380914211273,
-0.3805847465991974,
0.318318635225296,
-0.8508936762809753,
-0.05013933405280113,
-0.04153304547071457,
0.20407262444496155,
-0.1359860599040985,
0.10492920875549316,
0.15947569906711578,
-0.31769800186157227,
-0.11376117169857025,
0.21755877137184143,
0.33743828535079956,
0.28934580087661743,
-0.03627146780490875,
-0.4901962876319885,
-0.8266676068305969,
0.07034716010093689,
-0.28585386276245117,
-0.5403597950935364,
-0.5103546380996704,
-0.4628711938858032,
0.1552741676568985,
-0.3985101878643036,
0.01836216077208519,
-0.4922332465648651,
-0.2585757374763489,
-0.3697608709335327
] |
BACKGROUND Over the past 20 years the prevalence of child and adolescent mental disorders in high-income countries has not changed despite increased investment in mental health services. Insufficient contact with mental health services may be a contributing factor; however, it is not known what proportion of children have sufficient contact with health professionals to allow delivery of treatment meeting minimal clinical practice guidelines, or how long children experience symptoms prior to receiving treatment. AimsTo investigate the level of mental healthcare received by Australian children from age 4 years to 14 years. METHOD Trajectories of mental health symptoms were mapped using the Strengths and Difficulties Questionnaire. Health professional attendances and psychotropic medications dispensed were identified from linked national Medicare Benefits Schedule (MBS) and Pharmaceutical Benefits Scheme records. RESULTS Four trajectories of mental health symptoms were identified (low, high-decreasing, moderate-increasing and high-increasing). Most children with mental health symptoms had few MBS mental health attendances, and only a minority received care meeting study criteria for minimally adequate treatment. Children in the high-increasing and moderate-increasing trajectories were more likely to access care, yet there was no evidence of improvement in symptoms. CONCLUSIONS It is important that children and adolescents with mental health problems receive treatment that meets minimal practice guidelines. Further research is needed to identify the quality of care currently provided to children with mental health difficulties and how clinicians can be best funded and supported to provide care meeting minimal practice guidelines. Declaration of interestsNone. | [
-0.0048792096786201,
0.002511234488338232,
-0.017789162695407867,
0.01796000637114048,
0.023392237722873688,
-0.0031553381122648716,
0.009793004021048546,
0.004076362121850252,
-0.011946693062782288,
-0.031237920746207237,
0.0010815621353685856,
0.0179903507232666,
-0.002000038046389818,
0.015032797120511532,
0.021508879959583282,
0.014566447585821152,
-0.022942669689655304,
0.04491216689348221,
0.013384204357862473,
-0.01410598959773779,
0.010711871087551117,
-0.03989385813474655,
0.009441142901778221,
-0.016538353636860847,
0.01564524509012699,
0.022861376404762268,
0.017767315730452538,
-0.01975422352552414,
0.01765233650803566,
-0.0022157453931868076,
-0.029737960547208786,
0.022643545642495155,
0.0031244067940860987,
0.004019772168248892,
0.015445888042449951,
-0.01463066041469574,
0.012052442878484726,
0.01639517769217491,
-0.045613572001457214,
-0.0043226876296103,
0.024319585412740707,
-0.0028184656985104084,
-0.0014939344255253673,
0.021954016759991646,
-0.00900285318493843,
-0.0039055626839399338,
-0.011252569034695625,
-0.007170273922383785,
-0.019999105483293533,
0.016024116426706314,
-0.008531458675861359,
0.010832482948899269,
-0.012450538575649261,
-0.046783339232206345,
-0.006888506002724171,
0.0037734885700047016,
0.021336792036890984,
0.0028851479291915894,
-0.003358004614710808,
-0.02788802795112133,
0.006843220442533493,
0.008931317366659641,
0.002927647903561592,
-0.003669159021228552,
-0.0024411194026470184,
-0.06610851734876633,
-0.012273584492504597,
0.011422001756727695,
-0.008122418075799942,
-0.012538891285657883,
0.00753555865958333,
0.00005785792018286884,
0.0016140700317919254,
0.007229505106806755,
-0.0154903968796134,
0.012982098385691643,
0.022065386176109314,
0.019525635987520218,
0.005672165658324957,
-0.003893648274242878,
-0.010425476357340813,
-0.0039482577703893185,
-0.005997934844344854,
0.03390087932348251,
-0.030959047377109528,
-0.014066668227314949,
-0.012237303890287876,
0.00657981913536787,
0.010706277564167976,
0.02924383245408535,
-0.0002373172901570797,
-0.014556006528437138,
0.0034554717130959034,
-0.01495373249053955,
0.005864343605935574,
-0.03708559274673462,
0.0167051050812006,
0.005472853779792786,
0.04476560652256012,
-0.04088776186108589,
0.0018131901742890477,
-0.021675994619727135,
0.024348609149456024,
0.010795711539685726,
-0.029025563970208168,
0.005556225311011076,
-0.021188588812947273,
0.026450179517269135,
0.0004400787875056267,
0.005345424637198448,
0.007526824250817299,
0.023336810991168022,
0.004825640004128218,
0.007722772192209959,
0.010501956567168236,
-0.00786783266812563,
0.030734270811080933,
0.004008533898741007,
0.0045773545280098915,
-0.01715150475502014,
0.04030076414346695,
-0.01460668072104454,
-0.012044791132211685,
-0.010166257619857788,
-0.005125170573592186,
0.035412468016147614,
-0.011930186301469803,
-0.0332488939166069,
-0.02210242673754692,
0.011172880418598652,
-0.00834133755415678,
0.006842642091214657,
0.0028333435766398907,
0.0004495750181376934,
-0.021667467430233955,
-0.009448960423469543,
-0.01119360700249672,
0.007406453602015972,
-0.007471028249710798,
0.0024452973157167435,
-0.012098832987248898,
0.013775626197457314,
-0.001626610173843801,
0.012599608860909939,
-0.017575688660144806,
-0.009628506377339363,
-0.009812667034566402,
0.02045545168220997,
0.0024781255051493645,
-0.014116481877863407,
-0.0026867748238146305,
0.008521736599504948,
0.004449373576790094,
-0.01993929222226143,
-0.013802801258862019,
-0.0019235233776271343,
-0.011395329609513283,
-0.004019747022539377,
0.01806287094950676,
0.03190226852893829,
-0.025524694472551346,
0.02026432380080223,
0.04239535331726074,
0.010322321206331253,
0.010951373726129532,
0.0002673235721886158,
0.02257653698325157,
-0.015546299517154694,
0.002568647498264909,
0.001747249742038548,
-0.01085059717297554,
0.022127794101834297,
0.013357365503907204,
0.00526216346770525,
-0.009854286909103394,
-0.0055730026215314865,
0.011906612664461136,
0.011574968695640564,
0.017754070460796356,
0.06596580892801285,
-0.025307295843958855,
0.02390172705054283,
-0.018992677330970764,
-0.01998518779873848,
0.006320442073047161,
0.005258338060230017,
0.0065991077572107315,
-0.017941055819392204,
-0.05053440108895302,
-0.008204320445656776,
-0.00223845848813653,
0.012226325459778309,
0.018140066415071487,
-0.01164452824741602,
0.017550671473145485,
0.005511036608368158,
0.008848384022712708,
-0.007892617024481297,
-0.002099120058119297,
-0.02121509239077568,
0.01141090877354145,
0.009315066039562225,
0.010970646515488625,
-0.012899152003228664,
0.02005009539425373,
0.010366011410951614,
0.010488116182386875,
0.011214055120944977,
0.0028630716260522604,
-0.008236261084675789,
0.0030362142715603113,
0.012232477776706219,
0.006513996049761772,
-0.006021192297339439,
0.010472884401679039,
-0.016454754397273064,
-0.01971566677093506,
0.0033488203771412373,
-0.01788644678890705,
-0.019108979031443596,
0.0007947572157718241,
0.028462769463658333,
-0.027181515470147133,
0.020439457148313522,
-0.007419759873300791,
-0.009005093947052956,
0.01686091162264347,
0.0029920912347733974,
0.016936693340539932,
0.009481171146035194,
-0.011231806129217148,
-0.03261200711131096,
-0.003400934860110283,
0.02768760919570923,
-0.02023581601679325,
0.04055064544081688,
0.011475414969027042,
0.025163084268569946,
0.02626989223062992,
-0.015203343704342842,
0.003938273061066866,
-0.030301745980978012,
-0.008808497339487076,
-0.015746135264635086,
0.022643789649009705,
0.0009160146582871675,
0.020564241334795952,
-0.01068644504994154,
-0.04801742359995842,
-0.009117277339100838,
0.007135096471756697,
-0.027231965214014053,
0.038067154586315155,
0.005407394375652075,
0.008691757917404175,
0.019119691103696823,
0.0012470742221921682,
-0.01952243223786354,
0.02765653096139431,
-0.01717398129403591,
0.01588490605354309,
0.012417599558830261,
0.011378809809684753,
0.0012152825947850943,
-0.0010385471396148205,
0.006362008862197399,
0.03449487313628197,
-0.0009645475074648857,
-0.007818503305315971,
0.0016438771272078156,
0.00808708369731903,
-0.008532928302884102,
0.006980965379625559,
-0.08150015771389008,
-0.010644271969795227,
0.014483615756034851,
-0.0080874003469944,
0.01106368750333786,
-0.02049637958407402,
0.024087360128760338,
0.018097098916769028,
-0.002392249181866646,
-0.017406221479177475,
0.015370640903711319,
0.007569688372313976,
0.0006965528591535985,
-0.015278130769729614,
-0.017467008903622627,
-0.002595846075564623,
0.004156780894845724,
0.014155476354062557,
-0.018942860886454582,
-0.010373114608228207,
-0.0005891972687095404,
0.025883838534355164,
0.004158269613981247,
-0.01183312013745308,
0.006348166614770889,
0.029056021943688393,
0.02314719557762146,
-0.008808757178485394,
-0.025209011510014534,
0.008889634162187576,
-0.0019448581151664257,
0.007707921788096428,
0.0043928977102041245,
0.0034454972483217716,
0.004352828487753868,
0.01706818863749504,
-0.015689466148614883,
0.02409064956009388,
0.0016278622206300497,
-0.024385660886764526,
0.009747124277055264,
0.009313591755926609,
0.012686419300734997,
-0.0052215890027582645,
0.004915059078484774,
0.015206065028905869,
0.0027650289703160524,
-0.01693876087665558,
0.021828768774867058,
-0.016466105356812477,
0.013843805529177189,
-0.0035344113130122423,
-0.0032704854384064674,
0.004810865968465805,
-0.02902769297361374,
-0.026069888845086098,
0.0032813067082315683,
0.018211286514997482,
-0.00912403129041195,
-0.0008592534577473998,
-0.01890202984213829,
-0.05990924686193466,
0.0010224231518805027,
-0.011306742206215858,
-0.026153219863772392,
-0.02114238403737545,
-0.0035811825655400753,
-0.0036861635744571686,
-0.011167474091053009,
-0.00019357935525476933,
0.02584935538470745,
-0.00005801301449537277,
0.0001660529524087906,
-0.009940750896930695,
0.01240172516554594,
-0.0027422888670116663,
-0.021442165598273277,
0.01105873379856348,
-0.006173155270516872,
0.010641312226653099,
-0.024646129459142685,
-0.009878749027848244,
0.005105966702103615,
-0.00991909671574831,
0.01618318259716034,
-0.007885022088885307,
0.012780889868736267,
-0.007549176923930645,
0.026980118826031685,
-0.008445454761385918,
-0.006628002040088177,
-0.005115094594657421,
0.007428164128214121,
0.009040305390954018,
0.024590682238340378,
-0.0012767447624355555,
-0.007177239283919334,
-0.008862816728651524,
-0.004254648461937904,
0.00962880626320839,
-0.0014964034780859947,
-0.008699031546711922,
-0.05006784945726395,
-0.014348655939102173,
0.0050087859854102135,
0.007579726167023182,
-0.002710993867367506,
-0.006540975999087095,
-0.030471056699752808,
-0.009826994501054287,
0.008235219866037369,
-0.017434868961572647,
-0.0024326073471456766,
0.008768297731876373,
0.007641670294106007,
0.004277618136256933,
0.00955008901655674,
-0.021141741424798965,
0.07175716012716293,
0.0012335978681221604,
0.016929492354393005,
-0.011978424154222012,
-0.0371759757399559,
-0.03591693192720413,
-0.01899929903447628,
0.002176172100007534,
0.020276010036468506,
-0.03814076632261276,
0.014979543164372444,
0.01176292821764946,
-0.014554950408637524,
0.017854589968919754,
-0.0031456765718758106,
-0.009798532351851463,
-0.006153757683932781,
0.023259589448571205,
-0.021475505083799362,
0.0395127609372139,
0.03645027428865433,
0.01794346421957016,
0.02403879724442959,
-0.012542929500341415,
0.009517358615994453,
-0.012363463640213013,
-0.011195335537195206,
-0.009592622518539429,
-0.009588809683918953,
0.005193285644054413,
-0.02575172483921051,
0.03143168240785599,
-0.00108107749838382,
-0.0029854760505259037,
-0.009732290171086788,
-0.012918158434331417,
0.004449419677257538,
-0.002718500792980194,
0.002418078947812319,
-0.0030238116160035133,
0.007346875965595245,
-0.011054648086428642,
-0.01922936551272869,
0.010923461988568306,
0.0025760852731764317,
0.009316249750554562,
-0.004615706857293844,
-0.010258966125547886,
0.007979491725564003,
0.010534023866057396,
0.001802137354388833,
0.004529361613094807,
0.010852012783288956,
0.0007793139666318893,
-0.015621500089764595,
-0.0010255258530378342,
-0.02630343660712242,
-0.007500199601054192,
-0.014844652265310287,
-0.00015538663137704134,
-0.011657115072011948,
0.001043903874233365,
0.026749365031719208,
-0.012218194082379341,
-0.0036016302183270454,
-0.011466475203633308,
0.005031953565776348,
0.0029477011412382126,
-0.005687682423740625,
-0.00829772837460041,
-0.02139359712600708,
0.0029918078798800707,
0.004058748483657837,
0.0027584899216890335,
-0.02501641772687435,
-0.03197656571865082,
-0.008518163114786148,
-0.024834712967276573,
-0.012166205793619156,
-0.010130218230187893,
-0.007035042624920607,
0.005012453533709049,
-0.0016389077063649893,
-0.003515502903610468,
0.008025788702070713,
0.004744130186736584,
0.0053421612828969955,
-0.07471317797899246,
0.013128561899065971,
0.008874110877513885,
-0.018949704244732857,
0.007213372737169266,
-0.007127000018954277,
-0.01590895652770996,
-0.006549502722918987,
-0.043164994567632675,
-0.0048001655377447605,
-0.022155728191137314,
0.013688226230442524,
-0.006317875813692808,
-0.008641800843179226,
0.0175913255661726,
-0.00026013405295088887,
-0.02726851962506771,
0.0022711572237312794,
-0.006671051029115915,
-0.00361119257286191,
0.01797548495233059,
-0.009756193496286869,
-0.012292720377445221,
0.006560188718140125,
0.013351832516491413,
-0.0806935578584671,
-0.012477964162826538,
-0.004365385510027409,
-0.003921334631741047,
-0.030218088999390602,
0.0030708624981343746,
-0.0020946827717125416,
-0.011387464590370655,
-0.009988991543650627,
-0.014754694886505604,
0.015135896392166615,
0.00849783793091774,
0.03471418470144272,
-0.02248087339103222,
0.016592316329479218,
-0.0052125463262200356,
0.0010213705245405436,
0.004561586305499077,
-0.017830895259976387,
-0.019493302330374718,
-0.01475612260401249,
0.014883053489029408,
-0.0005986462929286063,
0.01927805319428444,
-0.0011792905861511827,
-0.019813502207398415,
-0.0013390500098466873,
0.01576146110892296,
-0.007519570644944906,
-0.014811134897172451,
0.01794568821787834,
0.007912888191640377,
0.010606992989778519,
-0.0022248104214668274,
-0.0000031418167054653168,
0.0026944465935230255,
0.019585145637392998,
0.004051727242767811,
0.003901237156242132,
-0.00772477313876152,
-0.010796699672937393,
-0.005465401336550713,
0.012436425313353539,
0.001128591364249587,
-0.01704971119761467,
0.010364128276705742,
0.009359031915664673,
-0.013717998750507832,
0.007377150934189558,
-0.007309284061193466,
0.01406281441450119,
0.002140713855624199,
0.0013491194695234299,
0.002829502569511533,
0.004294142127037048,
-0.012174185365438461,
-0.013399988412857056,
0.017381897196173668,
-0.005352078005671501,
0.018102243542671204,
0.0026148254983127117,
-0.008967166766524315,
-0.01976054161787033,
0.0710538774728775,
-0.016712509095668793,
0.018443480134010315,
-0.01647758111357689,
0.013960807584226131,
-0.0009899853030219674,
-0.018313119187951088,
-0.010824153199791908,
-0.035832155495882034,
0.005328166298568249,
-0.030621159821748734,
-0.014274806715548038,
-0.007845654152333736,
0.007084956858307123,
0.015359429642558098,
0.014882994815707207,
-0.028468389064073563,
-0.014761998318135738,
0.02160492166876793,
-0.02038358524441719,
0.03679319843649864,
0.02505910024046898,
-0.024051256477832794,
0.024489611387252808,
0.011039847508072853,
0.01823786273598671,
0.020022597163915634,
-0.01722332276403904,
0.005483812652528286,
0.01063734944909811,
-0.01642283797264099,
0.00753785902634263,
0.008025329560041428,
0.04204031080007553,
0.01444412861019373,
0.008839370682835579,
0.019293714314699173,
0.0013566520065069199,
0.010775573551654816,
0.02969452366232872,
0.02069859579205513,
-0.024327607825398445,
0.015164362266659737,
-0.011495459824800491,
-0.0045642005279660225,
0.005631692707538605,
0.011761032044887543,
-0.01593000255525112,
0.023269176483154297,
0.018318992108106613,
-0.026266785338521004,
0.004454502835869789,
0.0025164883118122816,
0.0069921063259243965,
0.002363735344260931,
0.009096542373299599,
-0.02339237555861473,
0.024008922278881073,
0.0015029758214950562,
0.001185643021017313,
-0.00828593596816063,
-0.008232898078858852,
0.010621871799230576,
-0.015370573848485947,
-0.0018370632315054536,
0.00917962659150362,
0.029193870723247528,
-0.0019140709191560745,
-0.004603027366101742,
0.007705584168434143,
-0.02592570334672928,
0.015350728295743465,
0.008705106563866138,
0.00021186703816056252,
-0.00952780432999134,
0.013896290212869644,
0.0011745160445570946,
-0.018615683540701866,
0.001265872735530138,
0.006134711671620607,
-0.017354007810354233,
-0.019203349947929382,
-0.03431595116853714,
-0.006598374806344509,
-0.011837717145681381,
0.0032746652141213417,
0.0174027718603611,
0.01854879781603813,
-0.018956506624817848,
0.0014866229612380266,
-0.030862215906381607,
0.00276787462644279,
-0.0039080302231013775,
0.015702081844210625,
0.01866588369011879,
0.03687227517366409,
-0.0212964229285717,
0.00969107635319233,
0.027018561959266663,
0.014411581680178642,
-0.023471325635910034,
0.04483263939619064,
0.010176878422498703,
0.019780928269028664,
0.0019633774645626545,
-0.00618688203394413,
0.0013459771871566772,
0.016375798732042313,
0.004756429232656956,
-0.0002880498068407178,
-0.01077747531235218,
-0.013210058212280273,
0.025760285556316376,
-0.009990114718675613,
-0.006145590916275978,
0.04138153791427612,
0.0011335010640323162,
0.009516936726868153,
-0.012492522597312927,
-0.019918378442525864,
-0.0032592853531241417,
0.004602024797350168,
-0.00954774022102356,
-0.0010530869476497173,
0.010554480366408825,
-0.010986510664224625,
-0.005166278220713139,
0.013734485022723675,
-0.0005330427084118128,
0.02347598597407341,
-0.0014329799450933933,
-0.024114111438393593,
0.006399639882147312,
-0.006210774183273315,
-0.000294980825856328,
-0.018931865692138672,
0.010336879640817642,
0.03258891776204109,
-0.015607734210789204,
0.0014680486638098955,
0.005389690399169922,
-0.003245905041694641,
0.005619053263217211,
0.007448678370565176,
0.011126480996608734,
0.017650868743658066,
-0.010186277329921722,
0.017060164362192154,
0.01877296157181263,
-0.007252839393913746,
0.013755392283201218,
-0.00453327689319849,
-0.009977936744689941,
-0.0014331960119307041,
0.003909138031303883,
0.009997928515076637,
0.002549627562984824,
0.011745288968086243,
-0.017430882900953293,
-0.0005698589375242591,
0.003836684860289097,
-0.036519020795822144,
-0.02034137025475502,
0.00927763618528843,
-0.020067621022462845,
0.01540871150791645,
-0.006498935632407665,
0.025086505338549614,
-0.011098160408437252,
0.008929054252803326,
-0.013182648457586765,
-0.0034809557255357504,
-0.022957198321819305,
0.015490013174712658,
-0.023001525551080704,
-0.002218137960880995,
-0.0023733717389404774,
0.019260751083493233,
-0.01395474560558796,
0.00972820445895195,
-0.009032094851136208,
-0.0029291785322129726,
-0.006715364754199982,
-0.013079924508929253,
-0.026606738567352295,
0.013284561224281788,
0.0036029911134392023,
0.004010932520031929,
0.017991889268159866,
-0.014095168560743332,
-0.0175161249935627,
-0.014135496690869331,
-0.016970321536064148,
0.0073272427543997765,
0.008188399486243725,
-0.0074525075033307076,
-0.017631346359848976,
0.04087626561522484,
0.017657017335295677,
-0.0008298704633489251,
0.0039922744035720825,
-0.021980416029691696
] | [
0.33249855041503906,
0.1126055121421814,
-0.17747816443443298,
0.07414533197879791,
0.12948022782802582,
0.6749727725982666,
0.7040003538131714,
0.20592279732227325,
-0.645338237285614,
-0.3326546847820282,
0.15047258138656616,
0.23327934741973877,
0.35107260942459106,
0.030462151393294334,
-0.23288576304912567,
0.4139697551727295,
0.5862401723861694,
0.5355884432792664,
-0.21776752173900604,
-0.5845333933830261,
-0.7637969851493835,
-0.28990498185157776,
0.727440357208252,
-0.05092401057481766,
0.30444419384002686,
-0.09522648900747299,
0.683381199836731,
0.22508788108825684,
-0.02079176902770996,
-0.11669927835464478,
-0.5797944664955139,
0.4223213195800781,
-0.03148321807384491,
0.25761568546295166,
-0.08475590497255325,
-0.07209916412830353,
0.03449276089668274,
0.0036556434351950884,
0.13949304819107056,
-0.4405152499675751,
-0.13482530415058136,
-0.3264728784561157,
-0.22956667840480804,
0.10769413411617279,
-0.05513698607683182,
-0.35397031903266907,
-1.3095028400421143,
0.0050978269428014755,
-0.005401303060352802,
-0.16065968573093414,
-0.04851290211081505,
0.4278201460838318,
0.5058030486106873,
-0.20397725701332092,
0.19688992202281952,
0.07830224931240082,
-0.24127845466136932,
-0.1610330045223236,
-0.06885013729333878,
-0.40942081809043884,
0.2192433625459671,
0.13596050441265106,
0.12713183462619781,
0.15077927708625793,
-0.2051016092300415,
0.14781899750232697,
0.16350071132183075,
0.3110758662223816,
0.12523677945137024,
-0.012169799767434597,
-0.2004239708185196,
-0.28882187604904175,
-0.3251311480998993,
-0.08186592906713486,
-0.34176141023635864,
0.44566482305526733,
-0.19979126751422882,
0.30395808815956116,
0.3224862217903137,
-0.6284967660903931,
-0.06491558253765106,
-0.27791085839271545,
0.41741979122161865,
-0.6516761779785156,
0.1546110212802887,
-0.08174854516983032,
0.29767295718193054,
0.45693594217300415,
0.005211839452385902,
0.007280618883669376,
-0.02641911245882511,
-0.28520068526268005,
0.1839507520198822,
1.0994035005569458,
-0.09018459916114807,
0.2772482633590698,
0.020111097022891045,
-0.16685016453266144,
0.49615296721458435,
0.2710086405277252,
0.35616442561149597,
-0.15835914015769958,
-0.34404000639915466,
-0.11447259783744812,
-0.314905047416687,
-0.1360027939081192,
0.3459777235984802,
-0.028095802292227745,
-0.9702634215354919,
-0.01107036042958498,
-0.8934909105300903,
0.13545703887939453,
-0.1689656674861908,
-0.24409985542297363,
-0.17915324866771698,
0.020795263350009918,
0.08859946578741074,
-0.04904087632894516,
-0.19780310988426208,
-0.02205159328877926,
-0.13716183602809906,
0.2888428270816803,
-0.2595275938510895,
0.3146463632583618,
0.3287007212638855,
0.469330370426178,
0.41954305768013,
0.002952047623693943,
0.19850724935531616,
0.15464352071285248,
0.21683721244335175,
0.13455475866794586,
-0.3498604893684387,
-0.18893617391586304,
-0.12984362244606018,
-0.05186472833156586,
0.22288937866687775,
0.4930671453475952,
0.3856765627861023,
0.1547994166612625,
-0.17894898355007172,
-0.4738475978374481,
-0.07402628660202026,
-0.1884930431842804,
0.12796708941459656,
-0.6780406832695007,
-0.1443231850862503,
-0.2531736195087433,
-0.09573564678430557,
-0.06822161376476288,
0.17130759358406067,
-0.33662113547325134,
-0.38501468300819397,
-0.40570053458213806,
0.0866619423031807,
0.007841059938073158,
0.05096615105867386,
-0.27867308259010315,
-0.2357843816280365,
0.09538398683071136,
0.42487436532974243,
0.6977007389068604,
-0.11653260141611099,
-0.21788345277309418,
0.8827734589576721,
0.15170355141162872,
-0.17761431634426117,
-0.09672080725431442,
0.12670369446277618,
0.36753660440444946,
-0.33477893471717834,
0.25942540168762207,
-0.2262754589319229,
-0.4673116207122803,
-0.5048299431800842,
-0.21279627084732056,
-0.05237689986824989,
0.3099234998226166,
-0.25350865721702576,
-0.19701355695724487,
-0.5284590125083923,
0.15587007999420166,
0.1213160902261734,
-0.3370695412158966,
0.11854590475559235,
0.043717995285987854,
0.2620289921760559,
-0.11283601075410843,
-0.004151633474975824,
-0.15247005224227905,
-0.16180269420146942,
-0.4977753758430481,
0.9147756099700928,
-0.9558901190757751,
1.0915309190750122,
-0.7518677115440369,
0.13012729585170746,
1.2072504758834839,
0.1814887672662735,
-0.17009979486465454,
0.3572101593017578,
0.05215742811560631,
0.12197531759738922,
0.4415073096752167,
-0.892536997795105,
0.061050012707710266,
0.14832788705825806,
0.05751273036003113,
-0.19229215383529663,
-0.2261868417263031,
0.39601972699165344,
-0.24708546698093414,
-0.5501890182495117,
-0.1709616780281067,
-0.003255530958995223,
0.1952422857284546,
0.12508182227611542,
0.07735101878643036,
-0.2615734934806824,
0.026425251737236977,
0.4026108980178833,
-0.45188257098197937,
0.2723012864589691,
0.10491787642240524,
-0.11225134879350662,
0.28858110308647156,
0.46370214223861694,
-0.3330370783805847,
0.4493210017681122,
-0.8854242563247681,
0.27156513929367065,
0.26241394877433777,
0.3783637285232544,
-0.6833202838897705,
-0.032893337309360504,
0.010032360441982746,
-0.2966579794883728,
-0.1901867836713791,
-0.07533666491508484,
0.06506209075450897,
-0.19516226649284363,
0.3290884792804718,
-0.706567108631134,
0.3214761018753052,
0.06696025282144547,
-0.2742772698402405,
-0.45047807693481445,
0.25199243426322937,
-1.1007860898971558,
0.14289811253547668,
0.08473657816648483,
0.15577194094657898,
0.2685253620147705,
0.02049659565091133,
-0.31041836738586426,
0.10494484752416611,
-0.35022127628326416,
-0.5357524156570435,
0.12149937450885773,
-0.42914366722106934,
-0.25617578625679016,
0.39634302258491516,
0.4334067702293396,
0.294863224029541,
0.11976604908704758,
-0.5649762153625488,
-0.5547946691513062,
-0.7543761134147644,
0.4431653916835785,
0.6367389559745789,
0.770341157913208,
-0.18190717697143555,
-0.629020094871521,
0.025646381080150604,
0.25088968873023987,
-0.3123229742050171,
0.23511095345020294,
0.3380579948425293,
-0.37880802154541016,
-0.5001189708709717,
-0.15837691724300385,
0.7443534135818481,
0.7443418502807617,
-0.28386130928993225,
0.24056094884872437,
-0.2566349506378174,
0.2730860710144043,
0.17196540534496307,
-0.437409907579422,
-0.02036144956946373,
0.05650898441672325,
0.2420995831489563,
-0.04531877115368843,
-0.39777639508247375,
0.7198355793952942,
0.4362400770187378,
-0.2663592994213104,
0.7692054510116577,
0.7591825723648071,
-0.0570220984518528,
0.29654166102409363,
0.1483761966228485,
-0.02338940091431141,
-0.07646499574184418,
-0.05714773014187813,
0.16014313697814941,
-0.4126451909542084,
-0.3875280022621155,
-6.052932262420654,
0.14077214896678925,
-0.6548329591751099,
-0.8083052039146423,
-0.31860029697418213,
0.07473409920930862,
1.031830072402954,
-0.24681708216667175,
0.207610622048378,
0.18223455548286438,
0.19587716460227966,
0.34757429361343384,
0.3181755244731903,
0.35653045773506165,
-0.028060954064130783,
0.08144021779298782,
0.22646231949329376,
-0.19590242207050323,
0.13478250801563263,
0.3690700829029083,
0.09837429225444794,
-0.28207460045814514,
-0.0008706401567906141,
0.47232142090797424,
0.35118621587753296,
0.38592782616615295,
-0.6109417676925659,
-0.2671439051628113,
-0.09024021774530411,
-0.4162968099117279,
0.1414010226726532,
-0.6389511227607727,
-0.234167218208313,
-0.28294506669044495,
0.4372274875640869,
-0.06304384022951126,
0.21947720646858215,
0.1780276745557785,
0.10485401004552841,
-0.48726484179496765,
-0.37321415543556213,
0.0507330596446991,
0.015438362024724483,
0.1290699541568756,
0.08442586660385132,
0.3049481511116028,
0.1426420509815216,
-0.1530807614326477,
-0.3931608498096466,
0.9887193441390991,
-0.08074648678302765,
0.09646125882863998,
-0.2934398651123047,
0.15400084853172302,
-0.10146841406822205,
0.0683652013540268,
0.4428859055042267,
0.02308543026447296,
-0.14574390649795532,
0.7464927434921265,
0.1729515641927719,
0.16618607938289642,
0.31145355105400085,
-0.5571962594985962,
-0.41430410742759705,
0.008084378205239773,
-1.2246676683425903,
-0.3336816728115082,
0.03255704790353775,
0.037392329424619675,
-0.5800523161888123,
-0.6297327876091003,
0.15874895453453064,
-0.5959725975990295,
-0.0028852473478764296,
-0.4107104539871216,
-0.1493259072303772,
0.6254420280456543,
0.06988204270601273,
-0.5809168815612793,
-0.1666610687971115,
-0.03835136070847511,
0.6074622273445129,
0.0570174865424633,
0.0260237455368042,
0.2998043894767761,
-0.4656790792942047,
0.2816102206707001,
0.019222738221287727,
0.27523157000541687,
0.6077679991722107,
-0.45273444056510925,
0.0691976249217987,
-0.010449574328958988,
0.5910191535949707,
1.0290894508361816,
0.4377230405807495,
0.2825995683670044,
0.3742237389087677,
-0.35578081011772156,
0.00019095710013061762,
0.06396391242742538,
-0.45118364691734314,
-0.7140893936157227,
-0.14138515293598175,
-0.02795204147696495,
-0.2924140393733978,
-0.2246537059545517,
0.49212104082107544,
-0.9694452285766602,
0.22800129652023315,
-0.4368005096912384,
-0.5775536298751831,
-0.07675238698720932,
0.3368786871433258,
-0.3783240020275116,
0.018241148442029953,
0.07908676564693451,
0.5503597259521484,
-0.23510892689228058,
0.21804744005203247,
0.17228612303733826,
-0.06208765506744385,
0.5086603164672852,
-0.4156348407268524,
-0.5008982419967651,
0.15484273433685303,
0.4130490720272064,
-0.6145622730255127,
0.19250896573066711,
0.36500778794288635,
0.44361767172813416,
-0.08061720430850983,
-0.3388686776161194,
-0.14457939565181732,
-0.2073465883731842,
-0.000862726999912411,
-0.12589091062545776,
0.3308578431606293,
-0.04410460218787193,
0.2630513310432434,
0.23376649618148804,
-0.1406095027923584,
0.23113296926021576,
0.5360022783279419,
-0.4576212465763092,
-0.25080400705337524,
-0.1449933499097824,
-0.23032498359680176,
-0.1335788518190384,
0.12853431701660156,
-0.20455987751483917,
0.4536890685558319,
-0.1352875828742981,
-0.7705337405204773,
0.10035288333892822,
0.2409113049507141,
-0.3652946352958679,
-0.35565119981765747,
-0.45984190702438354,
0.5682429075241089,
-0.08587200194597244,
-1.397265911102295,
0.1386360228061676,
0.6202393174171448,
-0.18555358052253723,
-0.03476645052433014,
-0.10233336687088013,
0.19588540494441986,
0.4587637484073639,
0.26091891527175903,
-0.6011167168617249,
0.22276432812213898,
0.04313010722398758,
0.17404791712760925,
-0.1909802258014679,
-0.1672997772693634,
0.07022494822740555,
0.01463641319423914,
-0.12028340250253677,
0.008142335340380669,
-0.04455140233039856,
-0.29527831077575684,
0.21426428854465485,
0.7210506200790405,
0.80604088306427,
-0.1363745480775833,
-0.05733445659279823,
-0.6867731213569641,
-0.3893137276172638,
0.36053919792175293,
0.10357028245925903,
0.4568636417388916,
0.25326842069625854,
-0.1224207654595375,
-0.22804495692253113,
0.10031364113092422,
0.29185840487480164,
0.0657123401761055,
0.06832460314035416,
-0.17527532577514648,
0.029118340462446213,
-0.12203573435544968,
0.45321354269981384,
0.4155811071395874,
-0.3502475321292877,
-0.15982688963413239,
-0.2685452997684479,
-0.3026927709579468,
-0.2942153513431549,
-0.003820885671302676,
-0.27161848545074463,
-0.5236728191375732,
0.5141988396644592,
-0.1325903981924057,
0.02451571263372898,
0.09561014920473099,
-0.2751184105873108,
-0.2791948914527893,
0.4570043683052063,
0.6171751618385315,
0.08590550720691681,
-0.6156917810440063,
0.11119111627340317,
-0.37438708543777466,
-0.053719665855169296,
0.8335508704185486,
-0.9492275714874268,
-0.1344345062971115,
0.4013247787952423,
-0.557697594165802,
0.17016884684562683,
0.5635849237442017,
0.22252918779850006,
-0.7869889140129089,
-0.0747850239276886,
-0.11874212324619293,
0.0833500474691391,
0.41328203678131104,
0.594168484210968,
-0.3382793068885803,
0.4056341350078583,
0.11560223996639252,
-1.0161614418029785,
-0.0016056125750765204,
0.009667632170021534,
0.33979111909866333,
-0.479116827249527,
-0.5051468014717102,
0.3866577446460724,
0.16293016076087952,
-0.35097363591194153,
0.24509945511817932,
-0.00814098585397005,
0.11037364602088928,
0.4202113151550293,
-0.5043985247612,
-0.5312027931213379,
-0.1494271457195282,
0.17296357452869415,
-0.11655625700950623,
-0.8064295649528503,
-0.2243383526802063,
-0.019966864958405495,
0.34683114290237427,
-0.08574459701776505,
0.042787063866853714,
-0.27948784828186035,
0.22126170992851257,
-0.46167096495628357,
0.005849744658917189,
0.01095360517501831,
0.8669033646583557,
0.34335803985595703,
0.3720232844352722,
-0.19293314218521118,
-0.23441164195537567,
-0.05546216294169426,
-0.045989956706762314,
0.01052293460816145,
-0.007077351678162813,
-0.2777106463909149,
0.003120940877124667,
-0.3877744972705841,
0.40610501170158386,
-0.3004639148712158,
0.2670188546180725,
-0.082643523812294,
-0.4706812798976898,
-0.49859392642974854,
0.2026156336069107,
-0.217924565076828,
-0.7438963651657104,
-0.22507038712501526,
-0.13313210010528564,
0.21439620852470398,
0.16135551035404205,
-0.2327040731906891,
0.2930765450000763,
-0.2927495539188385,
0.13896708190441132,
0.7306784987449646,
0.14459015429019928,
-0.18255843222141266,
0.13189391791820526,
0.2028321772813797,
0.11742447316646576,
-0.17459838092327118,
0.1254948079586029,
0.16819427907466888,
0.32285672426223755,
0.06541277468204498,
0.5956478714942932,
0.44311103224754333,
-0.3634631335735321,
0.3067598342895508,
0.02551918476819992,
-0.6060502529144287,
0.7707191109657288,
0.3340003788471222,
-0.15159879624843597,
0.4429660439491272,
0.8371720910072327,
-0.020702317357063293,
-0.021241018548607826,
0.5274706482887268,
0.27477478981018066,
0.15004055202007294,
0.45230409502983093,
0.17695410549640656,
0.1945677250623703,
0.7926854491233826,
-0.020808840170502663,
0.3312724828720093,
0.29072076082229614,
0.39713743329048157,
-0.03117542155086994,
-0.18795959651470184,
-0.09326989948749542,
0.3440581262111664,
1.122593879699707,
0.1203899011015892,
0.18819308280944824,
-0.33973631262779236,
-0.09695172309875488,
0.4475085139274597,
-0.045528240501880646,
0.41624870896339417,
-0.08226805180311203,
0.2904209494590759,
0.25844845175743103,
0.038873132318258286,
-0.20220746099948883,
0.04667000472545624,
-0.15541420876979828,
0.22376872599124908,
-0.19470272958278656,
-0.12019634246826172,
-0.8848565220832825,
0.049540575593709946,
0.022387314587831497,
0.270273357629776,
0.016133321449160576,
-0.020454276353120804,
-0.16709589958190918,
-0.11965048313140869,
0.29771947860717773,
0.47255024313926697,
-0.0738430842757225,
-0.25453394651412964,
-0.26437216997146606,
0.04626542329788208,
-0.36387714743614197,
-0.03413351997733116,
-0.20691803097724915,
-0.5445210933685303,
0.27946922183036804,
-0.16115529835224152,
-0.03078348934650421,
0.47792139649391174,
0.010045488364994526,
-0.12382454425096512,
-0.37317347526550293,
-0.23803459107875824,
0.2542223036289215,
0.0767553374171257,
-0.09959454089403152,
0.09418760985136032,
-0.2868669927120209,
0.007752209901809692,
-0.03542226925492287,
-0.31606510281562805,
0.3787185847759247,
0.6002876162528992,
-0.3123445510864258,
-0.20642268657684326,
-0.25729164481163025,
0.6090582609176636,
0.37033137679100037,
-0.06949476152658463,
-0.23909369111061096,
-0.14972633123397827,
-0.35978737473487854,
0.4469817280769348,
-0.21057283878326416,
0.33905309438705444,
-0.19134989380836487,
-0.23833522200584412,
-0.6804298162460327,
0.1137242466211319,
0.7545012831687927,
0.4357919692993164,
-0.07542075216770172,
-0.09589359909296036,
-0.13585083186626434,
0.5209803581237793,
0.5117737054824829,
0.13765481114387512,
-0.4030103087425232,
-0.2561081647872925,
-0.2126990109682083,
-0.7813407182693481,
0.46731823682785034,
0.022073660045862198,
-0.4214390218257904,
-0.28988218307495117,
0.13741379976272583,
0.4639233946800232,
-0.202240452170372,
0.178383469581604,
-0.10972090065479279,
-0.6227486729621887,
-0.26037001609802246,
0.5430959463119507,
-0.5438913702964783,
0.3063730001449585,
0.4365161657333374,
0.10964552313089371,
0.6059382557868958,
-0.15797004103660583,
-0.431427538394928,
-0.5704248547554016,
0.8191713094711304,
0.21288752555847168,
0.35026389360427856,
0.37919485569000244,
-0.2618650496006012,
-0.06965003162622452,
-0.8104423880577087,
0.02856275998055935,
-0.4078287184238434,
-0.46638578176498413,
-0.18031111359596252,
0.020305752754211426,
-0.20214185118675232,
-0.40919774770736694,
0.08418308943510056,
-0.3713679313659668,
-0.5037559866905212,
-0.4620574712753296
] |
This paper examines the potential impact of changes in medical care on changing population health in Lithuania, Hungary and Romania, with west Germany included for comparison. We used the concept of deaths from certain causes that should not occur in the presence of timely and effective health care (amenable mortality) and calculated the contribution of changes in mortality from these conditions to changes in life expectancy between birth and age 75 [e (0-75)] for the periods 1980/81 to 1988 and 1992 to 1997. Temporary life expectancy improved consistently in west Germany (men: 2.7 years, women: 1.6 years). In contrast, gains were relatively small in the other countries, except among Hungarian women, who gained 1.3 years. Romanian men lost 1.3 years. In the 1980s, falling infant mortality made a substantial contribution to improvements in temporary life expectancy in all countries, of about a quarter to half a year. Of this, more than half can be attributed to amenable conditions. At older ages, falling amenable mortality contributed about 40% among those aged over 40 in Germany and, to a lesser extent, Hungary, while causing a loss of life expectancy in Romania. In the 1990s, improvements in infant mortality continued to make substantial contributions to life expectancy in Lithuania and Hungary but had little impact in either Germany or Romania. Among adults, improvements in amenable mortality continued to benefit Hungarians and west Germans. In Lithuania, up to two-thirds of the gain in temporary life expectancy were attributable to falling mortality from ischaemic heart disease whereas medical care otherwise seems to have had a negative impact. Romanian men and women experienced increases in amenable mortality that contributed up to a half of the overall loss of life expectancy. Our findings suggest that during the last 20 years changes in medical care had considerable impact, positively as well as negatively, on changing mortality in selected central and eastern European countries. | [
-0.01012239046394825,
0.018001511693000793,
-0.025763865560293198,
0.004845538642257452,
0.022304076701402664,
-0.0011838499922305346,
0.009740396402776241,
-0.011497298255562782,
-0.010021524503827095,
0.002086186781525612,
-0.008470079861581326,
0.009401565417647362,
-0.0004422238562256098,
0.0031123810913413763,
0.010693799704313278,
-0.0031579637434333563,
-0.027400018647313118,
0.01758972369134426,
0.015935532748699188,
-0.019530650228261948,
0.004833419807255268,
-0.0036923708394169807,
0.00918827299028635,
-0.0036839693784713745,
0.004814669489860535,
0.008150431327521801,
0.008145024999976158,
-0.015826817601919174,
0.0019034217111766338,
-0.013575399294495583,
-0.004791644401848316,
0.02671048976480961,
-0.010533109307289124,
-0.015792356804013252,
0.009758581407368183,
0.00579545833170414,
0.008386412635445595,
0.01188458688557148,
-0.026250246912240982,
-0.004422323778271675,
0.03107895329594612,
-0.011225497350096703,
0.0031746469903737307,
0.009489748626947403,
-0.00921342521905899,
-0.00482808705419302,
-0.013156716711819172,
-0.009053545072674751,
0.005881649442017078,
0.013290708884596825,
-0.009733743965625763,
-0.025444258004426956,
-0.016872581094503403,
-0.0027922606095671654,
-0.006162501871585846,
0.016816511750221252,
0.017511382699012756,
0.0013130123261362314,
0.00024055573157966137,
0.019626911729574203,
-0.020176026970148087,
-0.03692556172609329,
0.01175395492464304,
0.007841558195650578,
-0.002359834499657154,
-0.06689847260713577,
0.008042409084737301,
-0.0091170072555542,
-0.011066358536481857,
-0.0168202742934227,
-0.024688346311450005,
0.005445618648082018,
0.009648445062339306,
-0.011500588618218899,
0.005382808856666088,
0.0069549125619232655,
0.010822037234902382,
-0.00481018889695406,
0.010840551927685738,
-0.0069893281906843185,
-0.017448078840970993,
-0.003738711355254054,
-0.005270389840006828,
0.02885010838508606,
-0.016752036288380623,
0.007436035200953484,
-0.006825044751167297,
-0.0022097721230238676,
-0.0074579156935215,
-0.016689961776137352,
0.007213829085230827,
-0.02186049148440361,
-0.010860418900847435,
-0.020756132900714874,
-0.036058537662029266,
-0.012219197116792202,
0.014275886118412018,
0.019568905234336853,
-0.015994813293218613,
-0.002261246321722865,
-0.00015137577429413795,
0.0016714445082470775,
0.012588275596499443,
0.000835099839605391,
-0.011811161413788795,
0.009416671469807625,
-0.01757768541574478,
0.0028647074941545725,
0.009936409071087837,
-0.0026141987182199955,
-0.027723249047994614,
0.007007007021456957,
0.01034586038440466,
0.0031149459537118673,
-0.003454959951341152,
-0.019124794751405716,
0.007124290801584721,
0.005330883897840977,
-0.002269302261993289,
-0.014591364189982414,
-0.008973745629191399,
-0.0073814233765006065,
-0.01578638330101967,
0.006989395245909691,
-0.004879981279373169,
0.013954883441329002,
0.015599728561937809,
-0.02097514644265175,
0.0012102369219064713,
0.0017080095130950212,
-0.006712626200169325,
0.0030295103788375854,
-0.021459737792611122,
-0.005084720440208912,
-0.010385118424892426,
-0.001248118351213634,
-0.029412174597382545,
0.011423774063587189,
0.009090348146855831,
0.008238016627728939,
-0.0034839611034840345,
0.008499350398778915,
-0.004954976961016655,
-0.0009878992568701506,
0.00018804916180670261,
-0.023743368685245514,
0.02413724735379219,
0.017528444528579712,
-0.008195258677005768,
-0.02329782024025917,
-0.025848980993032455,
0.0028192088939249516,
-0.0035447748377919197,
-0.009333193302154541,
0.001336163142696023,
0.015533370897173882,
-0.018517043441534042,
-0.005099431145936251,
-0.0059336405247449875,
0.0020394506864249706,
-0.004840418230742216,
0.018010176718235016,
0.016717858612537384,
0.008639862760901451,
0.016482073813676834,
0.016482887789607048,
-0.000050761736929416656,
-0.0011592237278819084,
0.011358728632330894,
0.0070852600038051605,
-0.01165445614606142,
-0.014052500016987324,
-0.009190978482365608,
0.012300227768719196,
0.011254498735070229,
-0.008896434679627419,
0.017700400203466415,
0.007877490483224392,
-0.0009078617440536618,
0.06665956974029541,
-0.025774385780096054,
0.013007916510105133,
-0.0064828963950276375,
0.009302139282226562,
0.013018800877034664,
0.016052162274718285,
0.017986739054322243,
-0.006808422971516848,
0.001304685603827238,
0.021659044548869133,
0.014221534132957458,
-0.025123231112957,
-0.0035026329569518566,
0.022847268730401993,
-0.010120956227183342,
0.004207066260278225,
0.019115405157208443,
-0.0029174145311117172,
-0.03055071085691452,
0.02463538944721222,
-0.011484389193356037,
0.0045865196734666824,
0.025904428213834763,
-0.0033669723197817802,
0.002516974462196231,
0.01913796365261078,
0.016814356669783592,
-0.02221667766571045,
0.015551283955574036,
-0.0005050939507782459,
0.004743434488773346,
0.0012299753725528717,
0.0005670820828527212,
-0.00025075642042793334,
-0.007990163750946522,
0.012201331555843353,
-0.007995719090104103,
0.004561223089694977,
-0.009444789960980415,
-0.01297757774591446,
0.006566646043211222,
0.02323789708316326,
-0.005957239307463169,
0.008393453434109688,
0.013943394646048546,
-0.019072284922003746,
0.007284821011126041,
0.008337847888469696,
0.0028367117047309875,
0.021619096398353577,
-0.03124195709824562,
-0.01896977424621582,
-0.004674999509006739,
0.01176135428249836,
-0.008613190613687038,
0.015969760715961456,
0.009530763141810894,
-0.022761426866054535,
0.013172721490263939,
-0.010394804179668427,
-0.00693394523113966,
-0.03404383361339569,
-0.010372928343713284,
0.011011967435479164,
0.011130240745842457,
-0.033106181770563126,
0.009454725310206413,
-0.008243078365921974,
-0.02019665017724037,
0.0007503913948312402,
0.0069622257724404335,
-0.02331440895795822,
0.017765725031495094,
0.010742711834609509,
0.011844205670058727,
0.009909951128065586,
-0.04976729303598404,
-0.004231657832860947,
0.025844814255833626,
-0.005801541730761528,
0.01285045687109232,
0.010189412161707878,
0.0036007952876389027,
-0.012755529955029488,
-0.007412414997816086,
-0.019227733835577965,
0.0021025100722908974,
0.02529260516166687,
-0.027370434254407883,
-0.001897256588563323,
0.007283859420567751,
-0.015467780642211437,
0.011785004287958145,
-0.08169062435626984,
-0.017715685069561005,
0.02240835130214691,
-0.021536733955144882,
0.005195903591811657,
0.025441337376832962,
0.021783310920000076,
0.006218415684998035,
-0.008307529613375664,
-0.015702733770012856,
0.0152072012424469,
-0.004133072216063738,
0.0012729837326332927,
-0.03214508295059204,
-0.004756398033350706,
-0.0008080222178250551,
0.005456347018480301,
-0.00140090542845428,
-0.0028774396050721407,
0.018831966444849968,
-0.006226616445928812,
-0.0032406579703092575,
0.03372921049594879,
-0.00900818221271038,
0.0110919289290905,
0.015993060544133186,
-0.005825438536703587,
-0.007582459133118391,
-0.0006616983446292579,
0.022003810852766037,
0.006706257350742817,
-0.03440038859844208,
-0.023266945034265518,
-0.020800361409783363,
-0.010947184637188911,
-0.0029701581224799156,
-0.01861177198588848,
0.022813240066170692,
-0.007094297092407942,
0.016521725803613663,
0.011742789298295975,
0.004676391836255789,
0.0020312066189944744,
-0.014972708187997341,
0.003721567802131176,
0.0011889806482940912,
0.007060852367430925,
-0.011935170739889145,
0.01152691338211298,
0.014784995466470718,
-0.010607998818159103,
-0.009058691561222076,
0.015950746834278107,
0.004468265455216169,
-0.011533789336681366,
-0.0020182770676910877,
-0.017351390793919563,
-0.0027675156015902758,
-0.006785551086068153,
-0.009723526425659657,
0.0041296351701021194,
-0.005721052642911673,
-0.013515308499336243,
0.028079546988010406,
0.005866102408617735,
0.014468523673713207,
0.0029581959825009108,
-0.009722203947603703,
-0.007125501055270433,
-0.012727838009595871,
0.034013234078884125,
-0.006645805202424526,
0.034129753708839417,
-0.017674917355179787,
0.002331684809178114,
-0.006711455062031746,
-0.012287169694900513,
-0.002681305166333914,
0.022625453770160675,
0.02662697061896324,
0.0032872091978788376,
-0.005872761365026236,
-0.025976676493883133,
0.019078068435192108,
-0.008837633766233921,
-0.019083451479673386,
0.007281504105776548,
0.022091858088970184,
0.008652690798044205,
-0.02112273871898651,
0.005955447442829609,
0.012723659165203571,
0.013229836709797382,
0.008826415054500103,
0.013117305934429169,
-0.023755740374326706,
0.003308619372546673,
-0.008403817191720009,
-0.0019734653178602457,
0.00853330735117197,
0.005665304139256477,
-0.008735422976315022,
0.005147863179445267,
-0.011850516311824322,
0.00872380007058382,
0.010493198409676552,
0.003961237613111734,
-0.00712315971031785,
-0.000907836714759469,
-0.0018322948599234223,
-0.015810435637831688,
0.002666262909770012,
-0.004386872053146362,
0.014077264815568924,
0.007275437004864216,
0.014587213285267353,
-0.015981819480657578,
0.0128993671387434,
0.07264368236064911,
0.008014298975467682,
0.02013476938009262,
-0.011736673302948475,
-0.013632187619805336,
-0.03385984152555466,
-0.005143626593053341,
-0.003155558370053768,
-0.002532364334911108,
-0.03805577754974365,
0.013270923867821693,
0.018794775009155273,
0.010091723874211311,
-0.03098655305802822,
-0.0013661781558766961,
-0.01253287773579359,
-0.01687484048306942,
-0.006892490666359663,
-0.00018892763182520866,
-0.0053672511130571365,
0.011882796883583069,
0.007847837172448635,
-0.031464166939258575,
0.003751175943762064,
0.02998766303062439,
-0.015657411888241768,
-0.02656508982181549,
-0.009393618442118168,
0.008981660939753056,
0.005957644898444414,
0.0069055077619850636,
0.04604040086269379,
-0.006423315033316612,
0.018943674862384796,
0.0244358591735363,
-0.00379742868244648,
-0.0006279004737734795,
-0.00430842163041234,
0.0023860041983425617,
-0.007957706227898598,
-0.008074063807725906,
-0.009738601744174957,
0.026382211595773697,
-0.0032761767506599426,
-0.015357532538473606,
0.004348165355622768,
-0.017827335745096207,
-0.0039743660017848015,
-0.007599163334816694,
0.018313098698854446,
0.003922144882380962,
0.013183631002902985,
0.010928129777312279,
0.018150394782423973,
-0.03549893945455551,
-0.0036632632836699486,
0.003721820656210184,
-0.010806542821228504,
-0.02045132964849472,
-0.00889168493449688,
0.018620364367961884,
0.004723272752016783,
-0.00015814672224223614,
-0.043859291821718216,
-0.011050627566874027,
-0.009404114447534084,
0.016430623829364777,
-0.011451564729213715,
0.021388156339526176,
-0.0076239756308496,
0.012651434168219566,
-0.0157880038022995,
-0.023090334609150887,
0.011920120567083359,
0.00007498485501855612,
-0.005333663430064917,
-0.0004616124788299203,
-0.02995225042104721,
0.006381216924637556,
-0.022834336385130882,
-0.011759020388126373,
-0.004663253203034401,
0.024257097393274307,
-0.005582867190241814,
0.02879256382584572,
0.010745964013040066,
-0.0028348034247756004,
-0.07564914226531982,
-0.007680810987949371,
0.009000863879919052,
-0.012742618098855019,
-0.003812413429841399,
0.016325388103723526,
-0.022223271429538727,
0.002077495912089944,
-0.027713345363736153,
-0.0013048214605078101,
-0.00977294147014618,
-0.0029240152798593044,
-0.01249883882701397,
0.002401268109679222,
0.015716277062892914,
0.013254016637802124,
-0.023874344304203987,
0.009890373796224594,
0.0124878641217947,
0.012604710645973682,
0.026379656046628952,
0.02079981192946434,
-0.014274481683969498,
-0.013220518827438354,
0.009376328438520432,
-0.08151322603225708,
0.013967260718345642,
-0.019849833101034164,
-0.008514521643519402,
-0.00862826593220234,
0.002058287151157856,
0.019984889775514603,
-0.014228357933461666,
-0.016700979322195053,
-0.012377233244478703,
-0.009079289622604847,
-0.002294480334967375,
0.009042466059327126,
-0.008487151935696602,
0.0017008226132020354,
0.0013553053140640259,
0.011156884953379631,
-0.016324877738952637,
-0.0038850409910082817,
-0.0034990916028618813,
-0.00033051054924726486,
0.015526808798313141,
-0.004751496482640505,
0.038082465529441833,
-0.004082082770764828,
-0.015572567470371723,
0.002526919124647975,
0.0008133617811836302,
0.0173654668033123,
-0.009473653510212898,
-0.007384582422673702,
-0.010127108544111252,
-0.003983530215919018,
0.00022502942010760307,
-0.00534112798050046,
-0.009899319149553776,
0.007479082327336073,
-0.014344794675707817,
-0.006505294237285852,
-0.002621124964207411,
-0.00030393502674996853,
0.01947331428527832,
0.021646635606884956,
0.010114013217389584,
-0.0021537316497415304,
0.0239349827170372,
0.011099355295300484,
-0.004430404864251614,
-0.0009700360824353993,
-0.016771085560321808,
0.00878947228193283,
-0.008258910849690437,
-0.003197448095306754,
-0.000668376567773521,
-0.019527830183506012,
-0.03328356146812439,
-0.010218005627393723,
-0.002116360003128648,
0.04057753458619118,
0.019169753417372704,
0.00844612903892994,
-0.005474329926073551,
-0.010660964995622635,
0.07175298035144806,
-0.008054330945014954,
-0.0071222856640815735,
0.005228808615356684,
-0.016580626368522644,
0.0038773654960095882,
0.0002732095308601856,
-0.01680843159556389,
-0.012942172586917877,
0.022607283666729927,
-0.017197974026203156,
0.008324834518134594,
-0.01064288429915905,
0.01445857435464859,
0.04100203514099121,
0.003969404846429825,
0.004095206968486309,
0.00853894092142582,
-0.03141617774963379,
-0.006052488926798105,
0.03609609231352806,
0.00018634460866451263,
-0.03011300414800644,
0.005633333697915077,
-0.000802615424618125,
0.0037414375692605972,
-0.004309971816837788,
-0.008817614987492561,
-0.0006962311454117298,
0.003600597381591797,
-0.01882348582148552,
-0.007806067820638418,
0.009942629374563694,
0.010606465861201286,
0.021257247775793076,
-0.005020264536142349,
0.013724456541240215,
0.007932787761092186,
0.005172973033040762,
0.00902404636144638,
0.027892282232642174,
-0.004019253887236118,
0.01434699073433876,
-0.008984838612377644,
0.02389967069029808,
-0.034419119358062744,
0.004101641941815615,
-0.02912909723818302,
0.010817138478159904,
0.004476330708712339,
0.023181186988949776,
0.0031497147865593433,
-0.032567597925662994,
-0.012295450083911419,
-0.003623473923653364,
-0.018903221935033798,
0.0062677208334207535,
0.023614149540662766,
0.014741845428943634,
-0.011625361628830433,
-0.0003410903736948967,
0.0029375432059168816,
0.007826131768524647,
-0.014360474422574043,
0.0002096064854413271,
0.0150926373898983,
0.012676432728767395,
-0.00857238657772541,
-0.006042867433279753,
0.0069060735404491425,
-0.023193981498479843,
-0.005221041850745678,
0.006691133603453636,
0.013158813118934631,
0.012906050309538841,
0.005122636444866657,
0.008666889742016792,
-0.009922916069626808,
0.001843721023760736,
-0.002189499093219638,
0.002338919322937727,
-0.018273456022143364,
0.031051628291606903,
0.002413131296634674,
0.005786081776022911,
0.022081052884459496,
-0.000726351689081639,
-0.002625242341309786,
-0.011763611808419228,
-0.007296600379049778,
-0.007972583174705505,
0.001429012045264244,
0.006910800933837891,
-0.00512720039114356,
0.007276327349245548,
0.03526894748210907,
0.02115710824728012,
0.0011228483635932207,
0.011157887056469917,
-0.0019590759184211493,
-0.029729433357715607,
-0.006517923437058926,
-0.017392203211784363,
-0.01847590133547783,
0.000017197802662849426,
-0.00888841226696968,
0.007782124914228916,
0.013715212233364582,
-0.0015395632945001125,
-0.0015076599083840847,
-0.012110893614590168,
-0.011881381273269653,
0.021386124193668365,
0.013369277119636536,
-0.0031748658511787653,
0.026645317673683167,
-0.0029255289118736982,
-0.03339698165655136,
0.004565222188830376,
-0.018459318205714226,
0.005462733097374439,
0.017446160316467285,
-0.00962977297604084,
0.014858109876513481,
-0.01264878362417221,
-0.009355748072266579,
-0.008617741987109184,
0.030486520379781723,
0.022606831043958664,
-0.004815240390598774,
-0.0023255343548953533,
0.00996791198849678,
0.002284550340846181,
0.004970392677932978,
0.004171709530055523,
0.008560771122574806,
-0.006118593737483025,
0.0073958495631814,
-0.028463104739785194,
0.018259914591908455,
0.0008126620668917894,
-0.00041109637822955847,
0.005582586862146854,
-0.01528261974453926,
0.008567001670598984,
0.017261065542697906,
-0.002134808339178562,
0.029538260772824287,
0.01968691311776638,
-0.006291118450462818,
-0.0041108885779976845,
0.02045830339193344,
0.007952851243317127,
-0.0073235658928751945,
-0.007573232054710388,
0.0029577715322375298,
0.004827136639505625,
0.008288098499178886,
0.017191389575600624,
-0.01324679795652628,
-0.005941508803516626,
-0.0000029319198802113533,
0.00828302837908268,
0.0028381056617945433,
-0.003337928093969822,
0.001570908585563302,
0.02607450820505619,
-0.019911818206310272,
-0.00323208374902606,
0.01640009507536888,
-0.007681248709559441,
-0.006613556295633316,
-0.0035503420513123274,
0.00638030469417572,
-0.026108579710125923,
0.003852215828374028,
-0.0026028240099549294,
0.00047462357906624675,
-0.012178155593574047,
-0.0009710730519145727,
0.0018241042271256447,
-0.015282089821994305,
-0.0044718533754348755,
-0.008174026384949684,
-0.0009795613586902618,
0.011417616158723831,
0.006933008320629597,
-0.005936361849308014,
0.01514589972794056,
0.016174595803022385,
-0.008585166186094284,
-0.026331951841711998,
-0.005507105961441994,
0.004374529700726271,
0.020228784531354904,
-0.006521654315292835,
0.010724121704697609,
0.000058625126257538795,
-0.007948122918605804,
0.011399617418646812,
0.027851086109876633,
-0.006622815039008856
] | [
0.2714773714542389,
-0.275154173374176,
0.22581084072589874,
-0.3685605823993683,
0.05743155628442764,
0.8521618843078613,
0.20340633392333984,
0.2190697342157364,
-0.538396418094635,
-0.2899720370769501,
0.008317798376083374,
-0.48258668184280396,
0.04840874299407005,
0.292891263961792,
-0.3372878432273865,
0.36398744583129883,
0.6246975660324097,
0.2197558730840683,
-0.03711296245455742,
-0.4018653333187103,
-0.08665642887353897,
-0.04672990366816521,
0.6449366807937622,
0.18801304697990417,
-0.430608332157135,
-0.33284711837768555,
0.6435952186584473,
0.018390968441963196,
-0.19776813685894012,
-0.11242000758647919,
-0.1358548402786255,
0.4138266444206238,
0.0181715190410614,
0.10868515074253082,
0.3892670273780823,
0.44090622663497925,
0.3387316167354584,
-0.1333410143852234,
0.18065181374549866,
-0.6350564956665039,
-0.3050984740257263,
-0.08812376111745834,
0.09746859222650528,
0.29474127292633057,
-0.35972529649734497,
-0.5268514752388,
-0.9830443263053894,
0.5118942856788635,
-0.255849152803421,
-0.02894708327949047,
-0.3381272256374359,
0.09867719560861588,
0.6519102454185486,
0.13743479549884796,
-0.3452451229095459,
-0.30421558022499084,
-0.335056871175766,
0.18646186590194702,
0.17076069116592407,
-0.06275545805692673,
0.34681808948516846,
-0.5344898104667664,
0.1078183501958847,
0.16081075370311737,
0.0019497500034049153,
0.38409262895584106,
0.21307894587516785,
0.2781910300254822,
0.2991466224193573,
-0.35066109895706177,
-0.1460590958595276,
-0.462009072303772,
-0.37311026453971863,
-0.06462085247039795,
-0.05113549157977104,
0.07103955000638962,
-0.41840216517448425,
-0.617020845413208,
0.19483177363872528,
-0.35705533623695374,
0.24643126130104065,
-0.40482407808303833,
0.6693740487098694,
-0.6788675785064697,
0.5418434143066406,
-0.06994408369064331,
0.21054229140281677,
0.33545348048210144,
-0.3481508791446686,
0.10444996505975723,
-0.2922978103160858,
-0.06750746071338654,
0.6361803412437439,
0.4623437523841858,
-0.6966162919998169,
0.3413119614124298,
0.05278138071298599,
-0.21802650392055511,
0.15605385601520538,
0.21454785764217377,
0.33482202887535095,
-0.026560956612229347,
-0.1427631974220276,
-0.26208168268203735,
-0.44148725271224976,
-0.7423860430717468,
-0.24911607801914215,
-0.36970385909080505,
-0.15094254910945892,
-0.09275554865598679,
-0.9688634872436523,
0.15650410950183868,
0.18404227495193481,
0.03917514532804489,
-0.0934387817978859,
0.44083771109580994,
-0.019171997904777527,
-0.5748946070671082,
0.06501319259405136,
0.22553378343582153,
-0.29025208950042725,
0.0776498019695282,
-0.14773333072662354,
0.02673359401524067,
0.30862677097320557,
0.17498879134655,
0.5624668002128601,
0.27964165806770325,
-0.17388898134231567,
0.47679173946380615,
0.3819820284843445,
0.49080395698547363,
-0.27409622073173523,
-0.014764323830604553,
0.36819514632225037,
-0.22731725871562958,
0.25200164318084717,
0.07930818200111389,
-0.09057413041591644,
-0.008700208738446236,
-0.18799088895320892,
0.13473792374134064,
-0.3774418830871582,
0.058028969913721085,
-0.006355274468660355,
-0.48929208517074585,
0.0307592935860157,
-0.04023515060544014,
-0.16816094517707825,
-0.23488998413085938,
0.20136570930480957,
0.16411086916923523,
-0.01993492990732193,
0.08209418505430222,
-0.023777108639478683,
0.28148940205574036,
-0.42836615443229675,
-0.11789559572935104,
0.4769640862941742,
-0.06653133034706116,
0.6522295475006104,
0.4266466796398163,
0.20150183141231537,
0.19305500388145447,
0.21925945580005646,
0.046646423637866974,
0.1422937959432602,
0.20351098477840424,
-0.08020125329494476,
0.3017270565032959,
-0.32762014865875244,
0.15179745852947235,
0.16445636749267578,
-0.2837085425853729,
-0.42500361800193787,
0.5334351062774658,
0.12458357214927673,
0.32324525713920593,
-0.128662571310997,
-0.14572679996490479,
-0.6588425040245056,
0.2222558856010437,
0.18494462966918945,
0.3543352484703064,
0.25041893124580383,
-0.08952857553958893,
0.143441841006279,
0.22485148906707764,
0.3950698971748352,
-0.09590210765600204,
-0.0229792483150959,
-0.5398998260498047,
0.2425263375043869,
-0.12002637982368469,
0.6656799912452698,
-0.1522083431482315,
-0.08799196779727936,
1.0135432481765747,
-0.19719649851322174,
-0.10657252371311188,
-0.04447796940803528,
-0.08698957413434982,
0.3113606572151184,
0.4282331168651581,
-0.09146461635828018,
0.18522542715072632,
-0.35172128677368164,
0.031930044293403625,
-0.06496017426252365,
0.22416749596595764,
0.45102840662002563,
-0.36116355657577515,
-0.3559446930885315,
-0.03768254071474075,
-0.159898579120636,
0.26412084698677063,
0.09619457274675369,
0.03703966736793518,
-0.08891332894563675,
0.040308114141225815,
0.5357691049575806,
-0.22269007563591003,
0.3938325047492981,
0.0031222684774547815,
0.45829954743385315,
-0.0743955448269844,
0.5874535441398621,
0.4819831848144531,
0.4062374532222748,
-0.8320991396903992,
0.08281872421503067,
0.24938547611236572,
0.1635785698890686,
-0.24565622210502625,
0.36506181955337524,
0.2127716839313507,
-0.2906561493873596,
-0.05183705314993858,
0.07866412401199341,
-0.4397670328617096,
0.17863193154335022,
-0.09621239453554153,
0.24360127747058868,
0.49760475754737854,
0.21854621171951294,
0.06405101716518402,
-0.3259284198284149,
0.17085449397563934,
-1.0089813470840454,
-0.22154325246810913,
0.2856840193271637,
0.4522123634815216,
-0.15523377060890198,
0.2762746512889862,
-0.04926057159900665,
-0.02628454379737377,
0.07493603229522705,
0.03910510614514351,
0.07898783683776855,
-0.18256454169750214,
0.36042407155036926,
0.03666737303137779,
0.49512481689453125,
0.13623006641864777,
-0.1562260538339615,
-0.04782237857580185,
-0.9053961634635925,
-0.9614644646644592,
-0.133861243724823,
0.39595022797584534,
0.17039617896080017,
0.01441805250942707,
-0.37229567766189575,
0.0879884883761406,
-0.16835953295230865,
-0.1382913738489151,
-0.36358875036239624,
0.5838279724121094,
-0.9644939303398132,
-0.1601308137178421,
-0.11437837034463882,
0.6735643148422241,
0.6802879571914673,
-0.4988299310207367,
-0.12192416191101074,
0.051991816610097885,
0.13439472019672394,
-0.0938861221075058,
-0.10332038253545761,
-0.10380367189645767,
-0.00990621279925108,
0.25937578082084656,
-0.13751019537448883,
-0.0855066105723381,
0.14385826885700226,
0.18857693672180176,
-0.05943455174565315,
-0.06946969032287598,
0.692377507686615,
0.21539565920829773,
-0.26985934376716614,
0.28596824407577515,
-0.23823094367980957,
0.14785142242908478,
-0.06774196028709412,
-0.3595246970653534,
-0.17662867903709412,
-0.01496070995926857,
-6.265048980712891,
0.29375553131103516,
-0.37561655044555664,
-0.4244169294834137,
0.05287812650203705,
0.07397161424160004,
1.0324243307113647,
-0.10509306937456131,
-0.34456294775009155,
0.22318878769874573,
0.4825628101825714,
0.4081535041332245,
0.0038731086533516645,
0.5965412259101868,
0.1733233779668808,
0.3161560297012329,
0.10912852734327316,
-0.0062490589916706085,
-0.0652238056063652,
-0.19783660769462585,
0.23880766332149506,
-0.389314740896225,
-0.12126986682415009,
0.31443992257118225,
0.6056553721427917,
0.24900583922863007,
-0.49982163310050964,
-0.10223085433244705,
-0.7491538524627686,
-0.44300270080566406,
-0.1736874282360077,
-0.40342092514038086,
0.12802965939044952,
0.2832021117210388,
0.5111435651779175,
0.40309980511665344,
0.13046248257160187,
0.6720146536827087,
0.3130744397640228,
-0.3874318599700928,
0.1957135945558548,
0.9780498743057251,
-0.27891620993614197,
-0.2556743621826172,
0.2198331356048584,
0.007777617312967777,
0.11507761478424072,
0.4518430829048157,
-0.5738735198974609,
0.596878707408905,
0.05185771360993385,
-0.283594012260437,
0.036946624517440796,
0.7981308102607727,
-0.2301253378391266,
0.2607930898666382,
-0.24717560410499573,
0.25812602043151855,
-0.03220763057470322,
0.22637882828712463,
-0.29255247116088867,
0.1235286220908165,
0.20700976252555847,
-1.0011073350906372,
-0.12546396255493164,
-0.1926967203617096,
-0.9161150455474854,
0.07959835976362228,
0.02113989368081093,
0.0495382659137249,
-0.16609075665473938,
-0.2972312271595001,
0.11836361140012741,
-0.9047450423240662,
0.15579800307750702,
-1.0252231359481812,
-0.27273815870285034,
-0.054061245173215866,
-0.17443329095840454,
0.17060969769954681,
0.22212272882461548,
-0.3305668532848358,
0.133919820189476,
0.27852392196655273,
0.5514974594116211,
-0.13164706528186798,
0.10168978571891785,
-0.3946278393268585,
-0.1684475541114807,
-0.37472105026245117,
0.3773924708366394,
-0.5569602847099304,
0.22667616605758667,
-0.021782241761684418,
-0.21116815507411957,
1.122809648513794,
-0.32918548583984375,
-0.18407216668128967,
0.08521666377782822,
-0.21590971946716309,
0.14994989335536957,
-0.05084128677845001,
-0.3944258391857147,
-0.459328293800354,
0.24701617658138275,
0.32470110058784485,
-0.42686277627944946,
0.15714263916015625,
0.36523759365081787,
-0.6053709387779236,
-0.2115102857351303,
0.09105576574802399,
-0.18529975414276123,
-0.7306627631187439,
0.40653368830680847,
-0.4391702711582184,
-0.1838991791009903,
0.10993348062038422,
-0.017052629962563515,
-0.015117901377379894,
0.2162618488073349,
-0.015946630388498306,
0.11312338709831238,
-0.0028741382993757725,
0.10125785320997238,
-0.14642581343650818,
-0.3465021848678589,
0.2578248679637909,
-0.31102845072746277,
0.6277521252632141,
0.22606615722179413,
0.37325477600097656,
0.15118856728076935,
-0.22106429934501648,
0.4584866762161255,
-0.08362066000699997,
-0.35234490036964417,
0.2990105450153351,
-0.1251935213804245,
-0.38682886958122253,
0.11296957731246948,
0.01424634363502264,
-0.10092810541391373,
-0.29785677790641785,
-0.1458713859319687,
0.020599763840436935,
0.1350223422050476,
-0.2273014336824417,
-0.4486004710197449,
0.11575392633676529,
0.23473471403121948,
-0.18226516246795654,
0.2793233096599579,
0.159098818898201,
-0.6127277612686157,
0.13642574846744537,
0.5653132200241089,
0.542153000831604,
-0.16218805313110352,
-0.3171175420284271,
-0.23199419677257538,
-0.1281369924545288,
-0.9356645941734314,
-0.14550641179084778,
0.6159135103225708,
-0.11046618223190308,
0.07227674126625061,
0.0930069163441658,
-0.08715225756168365,
0.451193243265152,
0.41197559237480164,
-0.23091572523117065,
-0.29798805713653564,
0.311349481344223,
-0.09033603966236115,
-0.31574925780296326,
-0.1911698579788208,
0.4044230282306671,
-0.00010406558430986479,
0.048941485583782196,
0.30714210867881775,
-0.07471878081560135,
-0.3252998888492584,
0.17294132709503174,
0.44134506583213806,
0.19195635616779327,
-0.10882551968097687,
-0.18231448531150818,
-0.015042616054415703,
-0.4409361481666565,
0.7520316243171692,
-0.34035229682922363,
0.4885897934436798,
-0.026926396414637566,
-0.2765292823314667,
-0.746519148349762,
-0.09285901486873627,
0.005216365214437246,
-0.32100173830986023,
0.13134124875068665,
0.01991928741335869,
0.006022733636200428,
-0.5969125032424927,
0.15819349884986877,
0.45621612668037415,
-0.21127541363239288,
0.21952708065509796,
-0.07958099991083145,
-0.12134388089179993,
-0.3499666154384613,
-0.6529659628868103,
-0.2724912762641907,
-0.14357741177082062,
0.5582085251808167,
-0.39697012305259705,
0.15027053654193878,
0.19006578624248505,
-0.7816321849822998,
-0.6075208187103271,
0.039427511394023895,
0.1639605164527893,
-0.2927722930908203,
-0.3816784620285034,
-0.5134855508804321,
-0.24116529524326324,
-0.3909614086151123,
0.23571951687335968,
-0.6854727864265442,
-0.06880426406860352,
-0.09145448356866837,
-0.09097857028245926,
-0.1648915410041809,
0.47539740800857544,
-0.014598848298192024,
-0.3920537233352661,
-0.27118000388145447,
-0.17147798836231232,
-0.43970149755477905,
-0.08621716499328613,
0.49171677231788635,
0.060793813318014145,
0.6306750774383545,
0.3247727155685425,
-0.3343579173088074,
0.06327737122774124,
-0.34876513481140137,
0.20946574211120605,
-0.4310566782951355,
-0.4960949718952179,
0.6948786973953247,
-0.040562935173511505,
0.08941839635372162,
-0.12082045525312424,
-0.5907484889030457,
0.6087889671325684,
0.09725702553987503,
-0.20641650259494781,
-0.34115368127822876,
0.27885326743125916,
0.4819563031196594,
-0.2842361629009247,
-0.0954589918255806,
0.2572733163833618,
-0.11497624963521957,
-0.02351522631943226,
0.21715179085731506,
0.08856166899204254,
0.010521871969103813,
0.3809024691581726,
-0.5831918716430664,
-0.09725585579872131,
-0.06736893206834793,
0.289890319108963,
-0.5369723439216614,
0.2706546187400818,
-0.027080949395895004,
-0.38209831714630127,
0.2051679641008377,
-0.024664629250764847,
0.10644680261611938,
-0.13567382097244263,
-0.19473479688167572,
-0.0685252770781517,
-0.159173384308815,
0.16328123211860657,
-0.42265474796295166,
0.23637109994888306,
-0.21603457629680634,
-0.6123858690261841,
-0.004091726616024971,
0.2315901815891266,
-0.13675446808338165,
-0.5633925199508667,
0.19465139508247375,
-0.000803569913841784,
0.16408704221248627,
0.4503125548362732,
0.4220482110977173,
-0.29559746384620667,
-0.3842299282550812,
-0.258948415517807,
0.24134917557239532,
0.3675122559070587,
-0.08042123168706894,
-0.15592911839485168,
0.018185781314969063,
0.24024613201618195,
-0.22272633016109467,
-0.03345007821917534,
0.28324565291404724,
0.6732348203659058,
0.0638451799750328,
0.48407861590385437,
0.9190635681152344,
-0.3967135548591614,
-0.03924847021698952,
-0.21232572197914124,
0.2961559593677521,
0.17417405545711517,
-0.06385712325572968,
0.09935224056243896,
0.10056757926940918,
0.5589068531990051,
-0.13917066156864166,
-0.04616039991378784,
0.5988187193870544,
0.44439491629600525,
0.4563017785549164,
0.030325816944241524,
0.2385060340166092,
0.31615710258483887,
0.6049732565879822,
0.06292638927698135,
-0.06855344772338867,
0.22080527245998383,
0.10011835396289825,
-0.04060151055455208,
-0.10173521935939789,
-0.2691653370857239,
0.219168558716774,
0.638723611831665,
0.21933378279209137,
-0.16685961186885834,
-0.052591472864151,
0.6147820949554443,
0.23863448202610016,
-0.19619309902191162,
0.07479666918516159,
0.5332652926445007,
-0.33366209268569946,
0.5584607720375061,
-0.2857639789581299,
-0.38293692469596863,
0.056166861206293106,
-0.5137404799461365,
-0.011650271713733673,
0.3966101109981537,
-0.5800995230674744,
-0.6234996318817139,
0.07746469974517822,
0.15876521170139313,
-0.37497398257255554,
-0.2315375655889511,
-0.00221985368989408,
0.08217331022024155,
-0.46402233839035034,
0.2795039415359497,
0.1153886616230011,
-0.05845640227198601,
-0.24809451401233673,
0.5492958426475525,
-0.15486948192119598,
-0.19088083505630493,
-0.17083866894245148,
0.2909790575504303,
-0.2809280753135681,
0.20287850499153137,
-0.2034331113100052,
0.1708480417728424,
0.5327873826026917,
-0.28985774517059326,
-0.1521880328655243,
0.056477535516023636,
-0.15166212618350983,
-0.6186578273773193,
0.09741661697626114,
0.02327434904873371,
-0.14204639196395874,
0.2727552056312561,
0.2275678664445877,
-0.05148470029234886,
-0.34313222765922546,
-0.05223243311047554,
0.056837134063243866,
-0.424808531999588,
-0.3111729621887207,
-0.15558822453022003,
0.4699947237968445,
0.4284061789512634,
0.25592875480651855,
0.18981073796749115,
-0.42611104249954224,
-0.21224476397037506,
0.16323064267635345,
0.10154175013303757,
0.6035791039466858,
-0.3641912341117859,
0.07234377413988113,
-0.16453315317630768,
0.12716248631477356,
0.5775388479232788,
0.3723227083683014,
-0.08590389043092728,
0.29055657982826233,
-0.11098182946443558,
0.07818671315908432,
0.46479037404060364,
-0.34999504685401917,
-0.10045178979635239,
-0.5096876621246338,
-0.3394557237625122,
-0.6996147036552429,
0.44397225975990295,
-0.4941435754299164,
-0.03752925992012024,
0.0805419459939003,
0.04719576984643936,
0.23141300678253174,
0.020647116005420685,
0.4183030426502228,
-0.4266122579574585,
0.18502765893936157,
0.20536649227142334,
0.04513514041900635,
-1.064941167831421,
0.4974331259727478,
0.19343645870685577,
0.07176074385643005,
-0.06580667197704315,
-0.46463918685913086,
-0.18868336081504822,
-0.2411688268184662,
0.13218916952610016,
0.2667909264564514,
0.6061280369758606,
0.18680459260940552,
-0.10437627881765366,
-0.10671956092119217,
-0.5207626223564148,
-0.18611297011375427,
-0.33804231882095337,
-0.3370300233364105,
0.30765417218208313,
-0.20008809864521027,
0.22491277754306793,
-0.26063671708106995,
-0.18492664396762848,
-0.6256673336029053,
0.05788140743970871,
-0.03515292704105377
] |
The Women's Interagency HIV Study comprises the largest U.S. cohort to date of human immunodeficiency virus (HIV)-seropositive women (N = 2,058) with a comparison cohort of seronegative women (N = 568). The methodology, training, and quality assurance activities employed are described. The study pop | [
-0.00377529114484787,
-0.005782402586191893,
-0.017796799540519714,
0.012069014832377434,
0.014315093867480755,
0.006318559870123863,
0.011401538737118244,
-0.007282492239028215,
-0.02324018068611622,
-0.02529602125287056,
0.0012499407166615129,
0.016853146255016327,
0.004494050517678261,
0.014313677325844765,
-0.010806163772940636,
-0.06584317982196808,
-0.02945915050804615,
-0.0073700957000255585,
0.008042434230446815,
0.008530070073902607,
0.022280937060713768,
-0.010735591873526573,
0.011229030787944794,
0.033418845385313034,
-0.032982561737298965,
0.04226753115653992,
-0.026175476610660553,
-0.01992960460484028,
0.02659563720226288,
-0.04059629887342453,
-0.008599174208939075,
0.020672257989645004,
0.00283835013397038,
-0.010049795731902122,
-0.010430198162794113,
-0.01804189383983612,
0.0033097148407250643,
0.032669540494680405,
0.011479930952191353,
-0.0030924833845347166,
0.02983343042433262,
-0.018455350771546364,
0.00013446866068989038,
-0.019459638744592667,
-0.006574616767466068,
0.02074352465569973,
-0.01829300820827484,
-0.0008172839879989624,
0.0063177128322422504,
0.01364171039313078,
-0.010267629288136959,
-0.02138061821460724,
-0.024891957640647888,
-0.027811463922262192,
-0.007578798104077578,
-0.008666113018989563,
0.018897047266364098,
-0.017832398414611816,
-0.03719017282128334,
0.023255180567502975,
-0.019804539158940315,
-0.044140588492155075,
-0.002608913229778409,
0.0008270262042060494,
-0.015955863520503044,
-0.06589210778474808,
0.001975086284801364,
0.0160819198936224,
0.006995093077421188,
-0.0019196750363335013,
0.009689279831945896,
0.02052827551960945,
0.006935000419616699,
0.0036942826118320227,
-0.039756130427122116,
0.003342845244333148,
0.015094917267560959,
0.019567079842090607,
-0.028481323271989822,
-0.010625013150274754,
0.052785370498895645,
0.017530081793665886,
0.02327931858599186,
0.021924341097474098,
-0.009094377048313618,
-0.010527655482292175,
-0.03724713250994682,
-0.022572210058569908,
0.039617203176021576,
-0.007084275595843792,
0.016753369942307472,
-0.0030182793270796537,
-0.0737200677394867,
-0.02029857411980629,
-0.026535140350461006,
-0.013184591196477413,
-0.06794221699237823,
-0.03192567080259323,
0.01678844913840294,
-0.037592045962810516,
-0.03384827449917793,
-0.0008713352144695818,
0.016585268080234528,
0.0139798978343606,
0.02101174183189869,
0.01674407161772251,
0.011651606298983097,
0.029875576496124268,
0.028343109413981438,
0.004873932339251041,
-0.02239922247827053,
-0.0017516628140583634,
0.013332313857972622,
0.00028286402812227607,
0.003110133809968829,
0.016646290197968483,
0.00322156329639256,
0.0274298544973135,
0.004723325837403536,
-0.027442386373877525,
0.01763535663485527,
-0.022169163450598717,
-0.007927823811769485,
0.02964286506175995,
0.0018753019394353032,
-0.02905096486210823,
0.04567525535821915,
0.025144681334495544,
0.024514110758900642,
0.013996072113513947,
-0.0033081963192671537,
0.0056567685678601265,
-0.00019410527602303773,
-0.07705658674240112,
-0.03066757135093212,
-0.00810930598527193,
0.014525014907121658,
0.02346174418926239,
-0.014835724607110023,
-0.014698165468871593,
-0.04589053615927696,
0.011743180453777313,
0.00700407987460494,
0.016792291775345802,
-0.012795654125511646,
-0.0027308494318276644,
-0.05653070658445358,
0.008939094841480255,
-0.0044144256971776485,
-0.02371959015727043,
-0.005159220192581415,
-0.007341956719756126,
-0.023654315620660782,
-0.03249521180987358,
0.005606710910797119,
-0.018525030463933945,
-0.034759439527988434,
-0.043409474194049835,
0.0048105777241289616,
-0.022557787597179413,
-0.0370260588824749,
0.03630412742495537,
-0.009588969871401787,
0.01127142645418644,
-0.009145866148173809,
-0.010197844356298447,
-0.030692890286445618,
0.005827553104609251,
-0.007550189271569252,
0.011131634935736656,
-0.01884329877793789,
0.0037884535267949104,
-0.01550581306219101,
0.014532691799104214,
0.005404598545283079,
-0.03859053924679756,
0.007073560263961554,
0.009034509770572186,
-0.006779992487281561,
0.06612958759069443,
0.023777225986123085,
-0.011565894819796085,
-0.020571192726492882,
0.03261011093854904,
0.017844852060079575,
-0.0032458973582834005,
0.024747589603066444,
-0.022557243704795837,
-0.008085716515779495,
-0.010247028432786465,
0.022770512849092484,
-0.04351520538330078,
0.005568338558077812,
-0.01665235124528408,
-0.038222264498472214,
0.005614581983536482,
0.012433318421244621,
0.02805596962571144,
-0.044146109372377396,
0.011795777827501297,
-0.0011918372474610806,
-0.005250764545053244,
0.005999716464430094,
-0.005524802953004837,
-0.041624873876571655,
0.0156549122184515,
0.036944735795259476,
0.010918540880084038,
-0.01992391236126423,
0.005050613544881344,
0.04495041444897652,
0.03470161184668541,
0.04196169599890709,
-0.02211529016494751,
0.017504073679447174,
-0.00542512908577919,
-0.0011142578441649675,
0.021790141239762306,
-0.039441537111997604,
-0.023394856601953506,
-0.008529230020940304,
0.0318823866546154,
-0.050408173352479935,
-0.0038577821105718613,
-0.008459905162453651,
-0.034697484225034714,
0.013176468200981617,
0.007380370981991291,
0.0026378019247204065,
0.006552585866302252,
-0.03549821674823761,
-0.023887179791927338,
-0.014457975514233112,
-0.0216402355581522,
-0.00645671458914876,
0.021588938310742378,
0.015959491953253746,
-0.004211985506117344,
0.007059754338115454,
-0.012090183794498444,
0.0020705792121589184,
-0.03732211887836456,
0.03914381191134453,
-0.0020603130105882883,
0.03822356089949608,
0.026681849732995033,
0.004680441226810217,
0.017024317756295204,
-0.011503314599394798,
0.003839726559817791,
0.009699264541268349,
-0.04913094639778137,
-0.003892497858032584,
-0.031370893120765686,
0.02969280630350113,
0.00575986597687006,
0.026606982573866844,
-0.014926068484783173,
0.025373712182044983,
0.010125490836799145,
0.026479577645659447,
0.0025395469274371862,
-0.009743777103722095,
-0.01557918731123209,
0.011552654206752777,
-0.0023134369403123856,
0.033460263162851334,
0.014088697731494904,
-0.008090002462267876,
-0.014585524797439575,
0.01359980646520853,
-0.008140589110553265,
0.011944908648729324,
-0.08086568117141724,
-0.0048853871412575245,
-0.0034293204080313444,
0.04460187256336212,
0.014143764972686768,
0.025432702153921127,
-0.02299501933157444,
0.016103873029351234,
0.0062456135638058186,
0.010641857981681824,
-0.01939324103295803,
0.0153419254347682,
-0.01528184674680233,
-0.00756687531247735,
-0.008053812198340893,
-0.000498803798109293,
0.00852296594530344,
-0.018218407407402992,
-0.046787239611148834,
-0.001986359478905797,
-0.021955085918307304,
0.009214291349053383,
0.025632331147789955,
-0.01120109111070633,
0.02919301949441433,
0.04087410494685173,
0.024592764675617218,
-0.008939854800701141,
-0.007979363203048706,
-0.0007201530388556421,
-0.0007961619994603097,
-0.015756919980049133,
0.03323729336261749,
-0.004489187151193619,
-0.013992820866405964,
-0.010675065219402313,
-0.040444739162921906,
0.01573287323117256,
-0.04189644381403923,
-0.02112478017807007,
-0.009232117794454098,
0.021716516464948654,
0.0395272821187973,
-0.021106544882059097,
0.0031340995337814093,
0.021163830533623695,
0.0001877463946584612,
0.050116781145334244,
0.022333581000566483,
-0.011496813967823982,
0.02192728780210018,
-0.018380558118224144,
0.022995688021183014,
0.0067724986001849174,
-0.013809112831950188,
-0.010252232663333416,
-0.03481630980968475,
0.04193444550037384,
-0.02434537373483181,
-0.010340661741793156,
0.009796502999961376,
0.027353007346391678,
0.0005716720479540527,
0.03242316469550133,
-0.03203101456165314,
0.04734652861952782,
0.015674158930778503,
-0.018412193283438683,
-0.007561486680060625,
0.014938481152057648,
-0.043516144156455994,
-0.009079650975763798,
0.025569560006260872,
-0.01465372834354639,
0.055719587951898575,
-0.003092179074883461,
-0.029016943648457527,
0.013558071106672287,
0.03148725628852844,
-0.008132103830575943,
0.026621975004673004,
-0.02034122310578823,
-0.020649341866374016,
0.008593587204813957,
-0.02959902584552765,
0.0338747501373291,
0.019347840920090675,
0.034219566732645035,
0.017125297337770462,
-0.030373981222510338,
0.029813244938850403,
0.04076981171965599,
0.005876835435628891,
0.010579857043921947,
-0.014536029659211636,
-0.027187993749976158,
0.005883101373910904,
0.0171748548746109,
-0.022901123389601707,
0.010172099806368351,
-0.015092991292476654,
-0.03709341213107109,
0.01581716164946556,
-0.005562696140259504,
0.00923940259963274,
0.03258799389004707,
-0.013316524215042591,
-0.01860157586634159,
-0.004418180789798498,
-0.0020243916660547256,
-0.0164437647908926,
0.0004082639643456787,
-0.008818497881293297,
0.05296493321657181,
0.02207089029252529,
0.032055243849754333,
0.038892537355422974,
0.03802858665585518,
0.06972412019968033,
0.010816709138453007,
-0.015628905966877937,
-0.01994163542985916,
0.012549624778330326,
-0.01111236959695816,
-0.010790887288749218,
0.02542082779109478,
-0.0015576215228065848,
-0.024271920323371887,
0.014920303598046303,
-0.006239387672394514,
0.006602946203202009,
-0.03589092567563057,
0.047769300639629364,
0.021036839112639427,
-0.02847045287489891,
-0.019247686490416527,
0.036547888070344925,
0.022155044600367546,
-0.024708816781640053,
0.05521020665764809,
0.010218373499810696,
0.00912360567599535,
-0.011037391610443592,
-0.019890276715159416,
-0.016485517844557762,
-0.010847814381122589,
-0.02381911128759384,
0.013462863862514496,
-0.011536442674696445,
0.013441585935652256,
-0.011432891711592674,
-0.040737081319093704,
-0.011866123415529728,
-0.015129880048334599,
-0.011188117787241936,
0.01325569674372673,
0.022529231384396553,
-0.016292067244648933,
0.008054710924625397,
-0.015915801748633385,
-0.03406282886862755,
0.023078378289937973,
-0.03755540773272514,
0.004960815422236919,
-0.02126714028418064,
-0.005980458576232195,
-0.01557016372680664,
-0.006975454743951559,
0.002287653274834156,
-0.012777825817465782,
0.019588151946663857,
0.020570283755660057,
0.0170122180134058,
-0.010768674314022064,
0.00660144817084074,
-0.0033349699806421995,
-0.014919567853212357,
-0.03196133300662041,
0.010198378004133701,
-0.022944727912545204,
-0.027800435200333595,
-0.013059268705546856,
-0.027354126796126366,
-0.02465013973414898,
-0.003874833695590496,
-0.004814106971025467,
-0.01439731102436781,
-0.03332360088825226,
0.0026257692370563745,
-0.026524612680077553,
-0.05048324912786484,
-0.008963149040937424,
-0.046487655490636826,
-0.006821267772465944,
-0.009574991650879383,
0.01106739230453968,
0.004240799229592085,
0.03510874882340431,
0.01260288804769516,
-0.01596381515264511,
0.01571117341518402,
-0.014512614347040653,
0.024460604414343834,
-0.0018454844830557704,
-0.022033190354704857,
-0.07170085608959198,
-0.03884028643369675,
-0.0012939211446791887,
-0.012552905827760696,
0.03128192201256752,
-0.00573481572791934,
-0.017042892053723335,
-0.025539139285683632,
-0.03595670685172081,
-0.01007838174700737,
-0.009444110095500946,
-0.020762097090482712,
0.02674817480146885,
0.010963785462081432,
0.017371350899338722,
0.049467895179986954,
-0.01231840904802084,
-0.019466781988739967,
-0.036087941378355026,
0.022099601104855537,
0.03385721892118454,
-0.0050997319631278515,
-0.023530535399913788,
-0.028435954824090004,
-0.007094188593327999,
-0.07846129685640335,
0.054956525564193726,
0.00559703866019845,
-0.030595695599913597,
0.029343146830797195,
-0.02518291398882866,
0.018040994182229042,
-0.009551545605063438,
-0.030850505456328392,
-0.021311813965439796,
-0.01841484010219574,
0.022870251908898354,
-0.04502411186695099,
-0.01333580818027258,
-0.011572173796594143,
-0.008301818743348122,
0.04085114598274231,
0.035081878304481506,
0.013299203477799892,
0.01742074452340603,
0.009080160409212112,
0.0038818230386823416,
-0.009511192329227924,
-0.0022564209066331387,
0.001955985324457288,
-0.003631416941061616,
-0.034564100205898285,
0.009825746528804302,
-0.007461976259946823,
-0.0381145179271698,
0.02385229989886284,
0.057623449712991714,
-0.003281358862295747,
-0.009505234658718109,
0.007514897268265486,
-0.012664388865232468,
0.00529690133407712,
-0.02930605784058571,
0.06886070966720581,
-0.00564577616751194,
-0.006294467020779848,
-0.03477004915475845,
0.012407624162733555,
-0.018664509057998657,
0.03564748913049698,
0.006825233809649944,
0.015448015183210373,
0.004168265964835882,
0.00841156393289566,
-0.05470053851604462,
0.000594276818446815,
-0.012110400944948196,
0.02100292593240738,
-0.015478502959012985,
0.012732692062854767,
-0.013976991176605225,
0.0051111518405377865,
0.04601087048649788,
0.007751155644655228,
0.013362286612391472,
-0.0034941204357892275,
0.0263527762144804,
-0.013634493574500084,
0.07133065164089203,
-0.028923144564032555,
0.019325971603393555,
0.029057150706648827,
0.011944933794438839,
0.00013204918650444597,
0.02043757773935795,
0.011378339491784573,
0.036802977323532104,
-0.019342128187417984,
-0.03031303733587265,
-0.004008399788290262,
-0.021313168108463287,
0.011615370400249958,
-0.03045068308711052,
0.022190039977431297,
0.003108269302174449,
0.0011179152643308043,
-0.0329875610768795,
0.023655802011489868,
0.005396320018917322,
-0.0031407244969159365,
-0.04868210479617119,
-0.07745957374572754,
0.03576148301362991,
-0.017140334472060204,
-0.009433023631572723,
0.014861393719911575,
-0.05858369171619415,
-0.002758943708613515,
-0.011319653131067753,
-0.023563627153635025,
0.010201292112469673,
-0.01757415570318699,
0.016721151769161224,
-0.03206918016076088,
0.0027056806720793247,
0.013362763449549675,
-0.020059553906321526,
-0.013580076396465302,
0.014485854655504227,
-0.019443929195404053,
0.010319752618670464,
-0.03542063385248184,
0.04624345526099205,
-0.036134641617536545,
-0.014859776943922043,
0.012426319532096386,
-0.03138617053627968,
0.043822694569826126,
0.003729928517714143,
0.003715751925483346,
0.00034989495179615915,
-0.0007877177558839321,
-0.05511604622006416,
0.005751073360443115,
-0.01225624606013298,
0.020388908684253693,
0.012624114751815796,
0.023942826315760612,
0.00378443137742579,
-0.0281847957521677,
-0.0018046960467472672,
-0.011315454728901386,
0.02035330794751644,
-0.024430515244603157,
0.04264769330620766,
-0.015172045677900314,
-0.022658860310912132,
0.021249528974294662,
-0.029286032542586327,
-0.016441186890006065,
0.009188620373606682,
-0.00007727115007583052,
-0.00847028661519289,
0.04014775902032852,
0.050261013209819794,
0.0069061871618032455,
0.024983806535601616,
0.032671283930540085,
-0.003227656939998269,
-0.002589633222669363,
0.02370508760213852,
-0.029961181804537773,
-0.018202925100922585,
-0.05499662086367607,
0.028963910415768623,
0.007222792133688927,
0.0015460572903975844,
-0.004182320088148117,
0.013666154816746712,
0.04082503914833069,
0.0022255685180425644,
0.015549518167972565,
0.011418391019105911,
0.035583823919296265,
-0.03325703367590904,
0.004166517406702042,
-0.016559306532144547,
-0.025151655077934265,
0.02859332598745823,
0.005601156502962112,
0.01835431531071663,
0.03615475818514824,
-0.008075573481619358,
0.01532051246613264,
0.03532087057828903,
0.03553900495171547,
0.05151867866516113,
0.0223098024725914,
0.034997738897800446,
-0.0020824968814849854,
0.026537450030446053,
0.019022759050130844,
0.012765346094965935,
0.0493805967271328,
-0.0028411506209522486,
-0.026192674413323402,
-0.033213257789611816,
-0.020928896963596344,
-0.004572633653879166,
-0.005359283182770014,
0.03905684873461723,
0.021109264343976974,
-0.001186729990877211,
0.011488093994557858,
-0.002646368695423007,
-0.0043814657256007195,
0.016021663323044777,
-0.022204803302884102,
0.019299158826470375,
-0.019399454817175865,
0.0070014838129282,
0.02131148986518383,
0.000007287452262971783,
-0.020559050142765045,
0.02363675646483898,
0.004412957467138767,
0.011687389574944973,
-0.0378955714404583,
0.004026785492897034,
-0.013270098716020584,
0.01696859300136566,
-0.009999376721680164,
0.011407710611820221,
-0.02581259049475193,
-0.024513326585292816,
0.004005356691777706,
0.012760932557284832,
0.0018903844757005572,
0.008536191657185555,
0.004738188814371824,
-0.0016533744055777788,
-0.011305217631161213,
-0.011462216265499592,
0.005927964113652706,
0.0034350662026554346,
-0.03124350681900978,
0.011940116994082928,
0.015880057588219643,
-0.01488533802330494,
-0.020767277106642723,
0.014415646903216839,
0.023457422852516174,
-0.0073240455240011215,
0.07799117267131805,
-0.03317032381892204,
-0.011757997795939445,
0.009940333664417267,
0.0017867371207103133,
0.04473583772778511,
-0.05850445479154587,
-0.007247267756611109,
0.014815481379628181,
-0.027476590126752853,
0.00600005965679884,
-0.0020747382659465075,
0.03214587643742561,
-0.010202610865235329,
0.04010298475623131,
-0.020887717604637146,
-0.017529798671603203,
0.022153660655021667,
-0.013510229997336864,
-0.018229754641652107,
0.02357097901403904,
-0.005334376357495785,
0.005679517053067684,
0.0066386335529387,
0.02805207297205925,
-0.013803869485855103,
-0.0032399471383541822,
-0.02032787911593914,
0.0054845428094267845,
0.021241264417767525,
0.01794445514678955,
0.0041873217560350895,
-0.009539085440337658,
-0.009209951385855675,
-0.027602380141615868,
-0.009107016026973724,
-0.0053394450806081295
] | [
0.01533810980618,
-0.29851025342941284,
-0.18097513914108276,
-0.053914718329906464,
-0.01022370159626007,
0.7026727795600891,
0.4157969355583191,
-0.16197986900806427,
-0.75074303150177,
-0.42297157645225525,
0.040627382695674896,
-0.019901644438505173,
-0.07074933499097824,
0.19599249958992004,
0.25747182965278625,
0.3368643820285797,
0.49312445521354675,
0.2782815992832184,
0.08483526855707169,
-0.5796145796775818,
-0.24110481142997742,
-0.36192265152931213,
0.40667566657066345,
-0.07972369343042374,
-0.14148768782615662,
0.08498839288949966,
0.4826960861682892,
-0.532864511013031,
0.3738062083721161,
-0.017717214301228523,
0.14172440767288208,
-0.03524753451347351,
0.20390814542770386,
0.0938231572508812,
0.2546350955963135,
0.038470737636089325,
-0.08586876094341278,
0.03248254209756851,
0.30029332637786865,
-0.08022059500217438,
-0.32227423787117004,
-0.3294597566127777,
-0.2788977324962616,
0.34977489709854126,
-0.14703375101089478,
-0.4134647846221924,
-1.0639076232910156,
0.5201318860054016,
-0.2346429079771042,
0.3892023265361786,
-0.5260258316993713,
0.01311411801725626,
0.9814838171005249,
0.36362025141716003,
-0.058366771787405014,
0.06289292871952057,
-0.4284818470478058,
-0.1529841274023056,
0.047244518995285034,
-0.5905029773712158,
0.09079677611589432,
0.0886286273598671,
0.4345342218875885,
-0.2674795985221863,
0.1763049215078354,
0.08414652943611145,
0.44292187690734863,
-0.015896571800112724,
-0.1068866103887558,
-0.41295668482780457,
0.09189353883266449,
-0.3398267924785614,
-0.3057968318462372,
-0.20275956392288208,
0.09379839897155762,
-0.35749226808547974,
0.09628472477197647,
0.03689970448613167,
0.28762075304985046,
-0.0383530892431736,
-0.40573182702064514,
0.2641810476779938,
0.15930989384651184,
-0.5853314995765686,
0.8594719767570496,
0.14313247799873352,
0.03935709968209267,
0.40129896998405457,
-0.45939287543296814,
0.17031602561473846,
-0.20087549090385437,
0.11805613338947296,
0.36864134669303894,
0.26981115341186523,
0.2370784431695938,
0.8599787950515747,
0.08826104551553726,
0.017808377742767334,
0.30392584204673767,
-0.19350391626358032,
-0.3443909287452698,
0.4669964909553528,
0.20545057952404022,
-0.18121200799942017,
-0.4833276867866516,
-0.19000689685344696,
0.29150763154029846,
-0.5095328688621521,
-0.22703967988491058,
-0.12015541642904282,
-0.1722320169210434,
-0.24694035947322845,
-0.06310191005468369,
-0.33625105023384094,
-0.401263028383255,
0.3795967102050781,
0.5373876094818115,
-0.43280738592147827,
0.13685302436351776,
0.08230646699666977,
-0.3607427477836609,
0.5098256468772888,
-0.001073536928743124,
0.4374898374080658,
0.13476809859275818,
0.029629724100232124,
0.1836935430765152,
0.01076843123883009,
-0.3639916181564331,
0.35908856987953186,
-0.1502029001712799,
0.4696536064147949,
-0.13145101070404053,
0.3389352560043335,
0.010236774571239948,
-0.7455216646194458,
-0.34189853072166443,
0.5334553122520447,
0.6982441544532776,
0.2328592836856842,
-0.462382435798645,
-0.43359875679016113,
-0.1418219953775406,
-0.2751992642879486,
0.3214189112186432,
-0.38616979122161865,
-0.24098198115825653,
0.04932494834065437,
-0.15007537603378296,
-0.032851237803697586,
-0.36306193470954895,
-0.16801421344280243,
-0.060321465134620667,
-0.39702093601226807,
-0.25013604760169983,
0.1392185539007187,
0.3548671305179596,
-0.05575883761048317,
0.3139764070510864,
0.2710731327533722,
0.2705775797367096,
0.5010952949523926,
-0.3238270580768585,
-0.1749575138092041,
-0.2520141005516052,
-0.11490698158740997,
0.45989638566970825,
0.18482936918735504,
-0.17734113335609436,
0.047331493347883224,
-0.21886472404003143,
-0.3074009120464325,
0.20934195816516876,
-0.2981269359588623,
-0.4641508460044861,
0.31422659754753113,
0.252959668636322,
0.3287930488586426,
-0.003495993558317423,
0.12487363070249557,
-0.3684769868850708,
-0.062219489365816116,
0.13635867834091187,
-0.29591044783592224,
0.4603903293609619,
-0.19209100306034088,
0.04147225245833397,
0.011410253122448921,
-0.3244202435016632,
0.0732145607471466,
0.2503069043159485,
-0.5053048729896545,
0.6232791543006897,
0.09141931682825089,
1.0966883897781372,
-0.2827140688896179,
-0.07619048655033112,
1.1323068141937256,
0.05227455496788025,
-0.7573289275169373,
0.04500530660152435,
-0.0618826225399971,
0.6132117509841919,
-0.24662087857723236,
-0.9712609052658081,
0.3952423632144928,
0.029755787923932076,
-0.07986819744110107,
-0.2869706451892853,
-0.178712859749794,
-0.017184196040034294,
-0.3425620198249817,
-0.05055665969848633,
-0.13089151680469513,
-0.02321591041982174,
0.3474014699459076,
0.010008680634200573,
0.12574392557144165,
0.43391183018684387,
0.06552013754844666,
1.194716215133667,
-0.5739168524742126,
0.9536144733428955,
0.20499874651432037,
-0.5071456432342529,
-0.16214844584465027,
0.16158618032932281,
0.2595679759979248,
0.43832725286483765,
-0.08900289982557297,
0.28192490339279175,
-0.06046910583972931,
0.5651469230651855,
-0.3613037168979645,
-0.13755935430526733,
0.30426427721977234,
-0.059362247586250305,
0.1561579555273056,
0.18050242960453033,
-0.29303961992263794,
0.08455286175012589,
0.9670681953430176,
-0.0324254184961319,
0.388908714056015,
0.024823347106575966,
-0.22344303131103516,
0.05381108447909355,
-0.00943254679441452,
-0.29509931802749634,
-0.05068746209144592,
0.16708599030971527,
0.3938842713832855,
-0.13616520166397095,
-0.3369913697242737,
0.11933047324419022,
-0.030420595780014992,
0.38554316759109497,
-0.3017571270465851,
0.6395053863525391,
-0.3701687753200531,
0.3945343792438507,
-0.07479806244373322,
-0.12248916923999786,
0.16684991121292114,
0.2414444088935852,
-0.38000327348709106,
-0.8849259614944458,
-0.6570388674736023,
0.5059465765953064,
0.06400252133607864,
0.7341426610946655,
0.5450419187545776,
-0.4070764183998108,
-0.07958036661148071,
0.13746432960033417,
-0.1047203540802002,
-0.0006568855023942888,
0.39808201789855957,
-0.4394266903400421,
-0.539059042930603,
-0.14243541657924652,
-0.17577721178531647,
0.7731945514678955,
-0.0770626813173294,
0.27158284187316895,
-0.5978296399116516,
0.19265922904014587,
-0.4261721670627594,
-0.16448268294334412,
-0.03113417513668537,
-0.012898687273263931,
0.4655214548110962,
0.06620869785547256,
-0.5531538128852844,
0.3808583617210388,
0.10779999941587448,
-0.3688303232192993,
0.9901520609855652,
0.5302673578262329,
0.38832271099090576,
0.011189712211489677,
0.3532212972640991,
-0.2554236650466919,
0.02196195162832737,
0.023923611268401146,
-0.286390483379364,
0.05263371020555496,
-0.11648765951395035,
-6.188575744628906,
0.308733195066452,
-0.7331750392913818,
0.027183307334780693,
-0.2185722440481186,
-0.43046408891677856,
0.5516613125801086,
-0.041128043085336685,
-0.03794867917895317,
0.009392731823027134,
0.5866987705230713,
0.6037015914916992,
-0.08123975992202759,
-0.01848112791776657,
0.015179520472884178,
0.5514571070671082,
0.23295381665229797,
-0.4417824149131775,
0.3221043348312378,
-0.13184387981891632,
0.06845200806856155,
-0.06613443791866302,
-0.107335165143013,
0.27711430191993713,
0.627634584903717,
0.09299704432487488,
-0.777428388595581,
-0.3570614755153656,
-0.29632827639579773,
0.0834159404039383,
-0.04096077382564545,
-0.3354589641094208,
-0.15125247836112976,
0.07185853272676468,
-0.03519519791007042,
-0.06544606387615204,
0.5070958733558655,
0.11846703290939331,
-0.06644405424594879,
-0.2781486511230469,
0.18043439090251923,
0.38466185331344604,
0.0832872986793518,
-0.4706028699874878,
0.3238011300563812,
0.27732211351394653,
0.028408629819750786,
-0.22796916961669922,
0.006474867928773165,
0.4220055639743805,
-0.26233920454978943,
0.14893165230751038,
0.08799738436937332,
0.3300141394138336,
0.1629347950220108,
-0.17049068212509155,
-0.4388355612754822,
0.7081417441368103,
-0.36044660210609436,
-0.1171460673213005,
-0.300121933221817,
-0.19732828438282013,
0.09822240471839905,
-0.634343683719635,
-0.24118463695049286,
-0.13246753811836243,
-0.8814663887023926,
0.15351508557796478,
0.10094106942415237,
-0.05868562310934067,
-0.04117384925484657,
0.4898529648780823,
0.12928475439548492,
-0.7021014094352722,
0.5623781085014343,
-0.4539984464645386,
0.005087975412607193,
0.1034967303276062,
-0.2734074890613556,
-0.4533408582210541,
-0.041609324514865875,
0.028108904138207436,
0.4735258221626282,
-0.15362359583377838,
0.25657933950424194,
-0.07480332255363464,
0.25554728507995605,
-0.2755652070045471,
-0.461923748254776,
0.15148167312145233,
-0.12025381624698639,
-0.2648983597755432,
0.32133185863494873,
0.3603706657886505,
0.6154075264930725,
0.5096893906593323,
0.30526334047317505,
0.7772631049156189,
0.021373681724071503,
-0.1526464819908142,
0.9760778546333313,
-0.35968801379203796,
-0.35549455881118774,
-1.2811888456344604,
-0.5969986915588379,
0.28631317615509033,
-0.2518412470817566,
0.09492950141429901,
0.988440990447998,
-0.6671847701072693,
-0.12547877430915833,
-0.05838620290160179,
-0.2668291926383972,
-0.4318356513977051,
0.5269174575805664,
0.1116408184170723,
-0.4354778826236725,
0.17740224301815033,
0.5540704727172852,
0.046702831983566284,
0.14937539398670197,
0.049567803740501404,
-0.06441256403923035,
0.26995906233787537,
0.36900290846824646,
-0.4413042366504669,
-0.1305253505706787,
0.2443472146987915,
-0.8843721151351929,
0.049458496272563934,
-0.24648047983646393,
0.6101927757263184,
-0.48884642124176025,
-0.41329556703567505,
0.18061406910419464,
-0.1636146754026413,
-0.5870314836502075,
0.56550532579422,
-0.04292156174778938,
0.005974748637527227,
-0.13656474649906158,
0.07245951145887375,
-0.0602683424949646,
0.44701045751571655,
-0.42853501439094543,
0.23512804508209229,
-0.3330519497394562,
-0.09926433116197586,
-0.29533806443214417,
-0.024961931630969048,
0.23623985052108765,
-0.4634743332862854,
0.5189532041549683,
0.0696573257446289,
-0.025234280154109,
0.04205012694001198,
1.0092151165008545,
0.6267418265342712,
-0.41015154123306274,
-0.37722915410995483,
-0.10010140389204025,
-0.3019184470176697,
-0.7265880703926086,
0.11522460728883743,
0.1754142791032791,
-0.3643253743648529,
-0.08964944630861282,
-0.24728870391845703,
-0.23722301423549652,
0.6015995740890503,
0.23598121106624603,
-0.49383774399757385,
0.33074915409088135,
-0.16262589395046234,
-0.026674579828977585,
0.27946019172668457,
-0.13218991458415985,
0.12546378374099731,
-0.15007203817367554,
0.66839200258255,
0.12438289076089859,
-0.5972537994384766,
-0.4254623353481293,
0.437656968832016,
0.3139828145503998,
0.5769617557525635,
0.13174952566623688,
-0.06156577169895172,
-0.0923260822892189,
0.3165089786052704,
0.3223293423652649,
-0.295850932598114,
0.18795245885849,
-0.33909687399864197,
-0.6895929574966431,
0.1022091880440712,
0.15010489523410797,
0.39130720496177673,
-0.3987249433994293,
0.006797267589718103,
-0.018515098839998245,
0.2630220651626587,
-0.6811161041259766,
0.4608370363712311,
0.22094978392124176,
-0.13122203946113586,
-0.30975261330604553,
-0.02807706966996193,
0.01666349358856678,
-0.2645575702190399,
-0.27337390184402466,
-0.029358455911278725,
-0.18914255499839783,
0.4426775872707367,
-0.2088792324066162,
0.2713775634765625,
-0.2770146131515503,
-0.565108060836792,
-0.15161003172397614,
0.16750143468379974,
-0.20684152841567993,
-0.41530942916870117,
-0.20424731075763702,
-0.25074440240859985,
0.0231302622705698,
0.5310271382331848,
-0.09432727843523026,
-1.0855265855789185,
-0.016471004113554955,
0.03614511713385582,
0.011593736708164215,
-0.3418739438056946,
0.15985651314258575,
0.1000237688422203,
-0.12017965316772461,
-0.3416876196861267,
-0.23434937000274658,
-0.061459269374608994,
0.22112882137298584,
0.20224079489707947,
-0.1979922205209732,
-0.1710490882396698,
-0.5390104055404663,
-0.5459578037261963,
-0.21436774730682373,
-0.1107233464717865,
0.07136347144842148,
-0.5931394696235657,
-0.14326433837413788,
-0.05000961944460869,
0.05263752117753029,
-0.7608693838119507,
0.0874687060713768,
-0.2088356614112854,
0.7084583044052124,
0.23678040504455566,
-0.16432614624500275,
-0.3963177800178528,
-0.44348835945129395,
-0.3363182246685028,
-0.24657098948955536,
-0.2635808289051056,
-0.7276425361633301,
0.0036975834518671036,
-0.07539313286542892,
-0.028489284217357635,
0.1831866353750229,
-0.4876959025859833,
-0.34895697236061096,
-0.026485875248908997,
-0.0024326250422745943,
-0.05923215299844742,
0.25793594121932983,
0.4790155291557312,
-0.03677652031183243,
0.2179037481546402,
-0.3139159679412842,
0.5787990689277649,
-0.12345181405544281,
0.24270442128181458,
-0.5147985816001892,
-0.37292760610580444,
-0.04730666056275368,
0.2528923451900482,
0.891922652721405,
-0.1570919156074524,
0.04022645950317383,
-0.15506184101104736,
-0.2793038785457611,
-0.10689738392829895,
0.4418881833553314,
-0.20103128254413605,
-0.34463125467300415,
-0.34720608592033386,
-0.040401339530944824,
0.08888453990221024,
0.31838101148605347,
0.13945193588733673,
-0.16521203517913818,
-0.38666921854019165,
-0.6201399564743042,
0.538502037525177,
0.3063177168369293,
-0.4829649031162262,
-0.20509572327136993,
-0.04058805853128433,
0.08101945370435715,
0.26457804441452026,
-0.4325234889984131,
0.051996536552906036,
0.1401999294757843,
-0.12483027577400208,
1.0344339609146118,
0.3638179302215576,
-0.7774651050567627,
-0.10137558728456497,
-0.1874695122241974,
-0.22986294329166412,
0.3250527083873749,
-0.3299064338207245,
-0.1937006413936615,
0.8799132704734802,
0.4914275109767914,
0.4400452971458435,
0.07514874637126923,
0.5777971148490906,
0.21967081725597382,
0.3480833172798157,
0.08966019749641418,
0.26418429613113403,
0.3666670322418213,
0.3257876932621002,
-0.4602764844894409,
0.2822929322719574,
0.2082081288099289,
-0.4438038468360901,
-0.2426156848669052,
-0.13141846656799316,
0.04312334209680557,
0.7803856730461121,
0.6638834476470947,
0.3619820475578308,
-0.274932324886322,
0.19329629838466644,
-0.16800141334533691,
0.06170840561389923,
0.02975103072822094,
0.010747081600129604,
0.25406965613365173,
0.028659826144576073,
0.25667425990104675,
-0.14340366423130035,
-0.25099897384643555,
0.11799496412277222,
-0.08299426734447479,
0.021372608840465546,
0.04587473347783089,
-0.2078176587820053,
-0.16573749482631683,
-0.32542163133621216,
0.10015073418617249,
0.2030254453420639,
-0.06307323276996613,
0.024997008964419365,
-0.011573302559554577,
-0.4215123951435089,
0.25945183634757996,
0.3612143397331238,
-0.388552725315094,
-0.19410505890846252,
0.5714077949523926,
-0.10428275913000107,
-0.3078606426715851,
-0.1736355423927307,
0.2566418945789337,
-0.1551712453365326,
-0.1264771819114685,
0.027978988364338875,
0.048143912106752396,
0.23122042417526245,
-0.20937693119049072,
0.3112759590148926,
0.1923033744096756,
-0.30074813961982727,
-0.2009662240743637,
0.12482575327157974,
-0.1112312376499176,
0.2790289521217346,
-0.18469150364398956,
0.08467519283294678,
0.46058496832847595,
-0.5105352997779846,
-0.3245786726474762,
0.11087594926357269,
-0.2350654900074005,
-0.061624880880117416,
0.14200475811958313,
0.4944232702255249,
0.30886128544807434,
0.7172806262969971,
0.08628913015127182,
-0.09121277183294296,
-0.10056591033935547,
0.4434579312801361,
-0.3871164917945862,
0.2486335188150406,
-0.3702631890773773,
-0.3046608567237854,
-0.26911160349845886,
-0.3399237096309662,
0.6956527829170227,
0.11305493116378784,
-0.3903855085372925,
0.16600751876831055,
0.1087251529097557,
0.6572534441947937,
0.6567302942276001,
-0.33587563037872314,
-0.32132866978645325,
-0.1972995549440384,
-0.2409350425004959,
-0.8029288053512573,
0.10914388298988342,
0.06750640273094177,
-0.19125132262706757,
0.22289004921913147,
0.3755691647529602,
0.14829732477664948,
0.13782404363155365,
0.5797277688980103,
-0.4732053875923157,
0.018935730680823326,
-0.22654804587364197,
0.2384709268808365,
-0.27109092473983765,
-0.1529494971036911,
-0.06312157958745956,
0.28875458240509033,
0.3884952664375305,
-0.38167884945869446,
-0.10933666676282883,
-0.41272714734077454,
-0.5954826474189758,
0.05152945592999458,
0.1611589640378952,
0.30551961064338684,
-0.16630250215530396,
-0.5493651628494263,
-0.19027777016162872,
0.20212377607822418,
-0.4234488606452942,
0.025277355685830116,
-0.14323873817920685,
-0.40181130170822144,
-0.23206068575382233,
0.07419516146183014,
0.6473976969718933,
-0.2700731158256531,
0.3639001250267029,
0.13431432843208313
] |
Metabolic syndrome is diagnosed when three or more of the following criteria are met: abdominal obesity (waist circumference more than 102 cm in men and 88 cm in women); hypertriglyceridemia of 150 mg/dl or above; a high-density lipoprotein (HDL) cholesterol level less than 40 mg/dl in men or 50 mg/dl in women; blood pressure of 130/85 mm Hg or higher; or fasting glucose of at least 110 mg/dl. Individuals with metabolic syndrome are likelier than others to develop diabetes and cardiovascular disease and have increased mortality from all causes (and from cardiovascular disease in particular). The investigators attempted to determine the prevalence of the syndrome in the United States by analyzing data on 8814 men and women 20 years of age or older who took part in the Third National Health and Nutrition Examination Survey in the years 1988 to 1994. This is a cross-sectional health survey of a sample of the noninstitutionalized civilian American population. The overall age-adjusted prevalence of metabolic syndrome was 23.7%. The prevalence rose from 6.7% in persons 20 to 29 years of age to 42% in those aged 70 years and more. There was virtually no gender-related difference in prevalence rates for the combined racial groups. Metabolic syndrome was most prevalent in Mexican Americans and least prevalent in whites, African Americans, and "others. " Among both African Americans and Mexican Americans, women had higher prevalence rates than men. Extrapolating from age-specific prevalence rates and US census counts from the year 2000, 47 million US residents have metabolic syndrome. Considering its prevalence, it seems important to estimate the direct medical costs of metabolic syndrome. In the great majority of cases the critical causes are improper nutrition and insufficient physical activity, emphasizing the importance of controlling obesity and encouraging physical activity in the United States. | [
0.0005137005355209112,
-0.006278956774622202,
-0.01741575263440609,
0.015432637184858322,
0.00047067180275917053,
0.03240581974387169,
0.008652795106172562,
-0.011216338723897934,
-0.00927746668457985,
-0.028999414294958115,
-0.002726705279201269,
0.0033267210237681866,
-0.005627533886581659,
0.024305522441864014,
0.0033372528851032257,
0.005785022396594286,
-0.020155861973762512,
0.011546285822987556,
0.004358096979558468,
0.021093837916851044,
0.01584990881383419,
-0.012500082142651081,
0.008937254548072815,
0.037154026329517365,
0.016841530799865723,
0.019393261522054672,
0.034422531723976135,
-0.02096880041062832,
-0.006541680544614792,
-0.011484593152999878,
-0.030592989176511765,
0.002744486555457115,
0.011428214609622955,
-0.030519992113113403,
0.012318947352468967,
0.028350260108709335,
0.0021766037680208683,
0.007866445928812027,
-0.003125067800283432,
-0.003992979880422354,
-0.014607954770326614,
-0.01008695363998413,
0.004065155982971191,
0.00029828259721398354,
-0.010829072445631027,
0.02116391807794571,
0.001671257079578936,
-0.012539162300527096,
-0.012991707772016525,
0.0072656720876693726,
-0.022104885429143906,
-0.049186572432518005,
-0.016182707622647285,
-0.00010268157348036766,
-0.0058001624420285225,
0.012131443247199059,
0.01793863996863365,
0.009887443855404854,
-0.0169894527643919,
0.011341228149831295,
0.03943053260445595,
-0.006903430446982384,
-0.010511260479688644,
0.01924974098801613,
0.004606324248015881,
-0.06732983142137527,
0.00019596703350543976,
-0.007127249147742987,
-0.020296279340982437,
-0.003204498440027237,
-0.008176745846867561,
0.00773240253329277,
0.001825639046728611,
-0.007918087765574455,
-0.0010505085811018944,
-0.0017717918381094933,
-0.017126910388469696,
0.0022751446813344955,
0.023176399990916252,
-0.009370592422783375,
-0.002196583431214094,
0.010396454483270645,
0.0002710756380110979,
0.001091205282136798,
-0.008244683034718037,
-0.023107202723622322,
-0.009489147923886776,
-0.008999539539217949,
-0.005454258061945438,
0.03827575221657753,
-0.010699726641178131,
0.0058639273047447205,
-0.008184955455362797,
-0.014662070199847221,
-0.04457176476716995,
0.0027014652732759714,
-0.013317916542291641,
0.018396412953734398,
0.01678376831114292,
-0.0028244098648428917,
-0.008212459273636341,
0.0026488699950277805,
0.004711226560175419,
0.005560991819947958,
-0.010876796208322048,
0.00740453414618969,
-0.0073910001665353775,
0.031987905502319336,
0.015011947602033615,
0.011246943846344948,
-0.025425881147384644,
0.01856740564107895,
-0.010759162716567516,
-0.021601032465696335,
-0.004958119243383408,
-0.006969946902245283,
-0.017248215153813362,
0.003524644300341606,
0.0026812003925442696,
0.006735943723469973,
-0.03132850304245949,
0.005977836437523365,
-0.00006785182631574571,
0.011936661787331104,
-0.0037026265636086464,
-0.005050627514719963,
0.00829208455979824,
0.0026145977899432182,
0.01777569390833378,
0.002752007683739066,
-0.006502477917820215,
0.013363280333578587,
-0.011611864902079105,
-0.025011464953422546,
-0.008373968303203583,
0.0057686022482812405,
-0.033504169434309006,
0.011377744376659393,
-0.021579284220933914,
-0.019754957407712936,
-0.00017099780961871147,
0.013350379653275013,
0.0030388636514544487,
0.014960571192204952,
-0.009315673261880875,
-0.008904549293220043,
-0.01589907333254814,
0.0026000002399086952,
0.02553457021713257,
-0.014945833012461662,
-0.0016402625478804111,
0.015240367501974106,
-0.014400945976376534,
-0.027199510484933853,
-0.01479068212211132,
0.005684124305844307,
-0.011900740675628185,
0.016399621963500977,
0.016697051003575325,
0.011234739795327187,
-0.0011397041380405426,
0.019845610484480858,
0.012445280328392982,
0.010226059705018997,
-0.01953274942934513,
-0.011711452156305313,
-0.027070479467511177,
-0.012154252268373966,
-0.002054013079032302,
0.0032701881136745214,
-0.001274281064979732,
-0.029267380014061928,
0.015283309854567051,
0.005176263395696878,
0.006113296840339899,
0.002157404087483883,
-0.008462920784950256,
0.007077522575855255,
0.007733641657978296,
0.06714390963315964,
-0.000921555794775486,
0.014263447374105453,
0.007316692732274532,
-0.010994914919137955,
0.032357003539800644,
0.009438969194889069,
0.003650669939815998,
-0.007836121134459972,
-0.021702904254198074,
0.005930963903665543,
0.021027859300374985,
0.013324374333024025,
0.03028157539665699,
0.004065459594130516,
-0.013181066140532494,
0.0038473852910101414,
0.0034551455173641443,
0.00026182690635323524,
0.00958186574280262,
-0.02792980521917343,
0.025453492999076843,
-0.007207442075014114,
0.02628801390528679,
0.011414851993322372,
0.015728842467069626,
0.015195919200778008,
0.03651311248540878,
0.00043194089084863663,
-0.017637940123677254,
0.0067346906289458275,
0.011012941598892212,
-0.0022164476104080677,
0.0012764623388648033,
-0.004772552289068699,
-0.0008089053444564342,
-0.011455834843218327,
-0.0029661552980542183,
-0.0014261221513152122,
-0.016015823930501938,
-0.0129183828830719,
0.00932876393198967,
-0.019526910036802292,
-0.017001677304506302,
-0.00004492397420108318,
-0.010922226123511791,
-0.016318228095769882,
0.019443998113274574,
0.0068803695030510426,
-0.006751334294676781,
0.0012444851454347372,
-0.009287558495998383,
-0.0033927657641470432,
-0.007666806690394878,
-0.00985824503004551,
0.007936811074614525,
0.0056022037751972675,
0.00854269228875637,
0.012767279520630836,
0.014301780611276627,
-0.01688724011182785,
0.001836169045418501,
-0.034077998250722885,
0.0034547813702374697,
-0.02042001485824585,
0.02669214829802513,
0.016236450523138046,
-0.004513201769441366,
0.013145014643669128,
0.0065214019268751144,
0.006652637384831905,
0.00840943492949009,
-0.016829941421747208,
-0.02003626711666584,
-0.006791622377932072,
-0.0004781670868396759,
-0.044088371098041534,
0.0014952677302062511,
-0.005712881684303284,
0.023462630808353424,
-0.008526595309376717,
0.023740114644169807,
0.006969212554395199,
0.023939546197652817,
0.038915883749723434,
-0.017090952023863792,
0.015794822946190834,
-0.010309625416994095,
-0.00957251712679863,
0.02508513443171978,
0.008629350923001766,
0.008164246566593647,
-0.013959131203591824,
-0.008303582668304443,
-0.08105774223804474,
-0.010403398424386978,
0.004040146246552467,
0.005751105956733227,
0.0055673932656645775,
-0.006157738622277975,
0.010711190290749073,
0.009945460595190525,
-0.004055503755807877,
-0.024493884295225143,
0.004971270449459553,
-0.014315301552414894,
-0.005340090952813625,
0.026136601343750954,
-0.01788666844367981,
0.0051213596016168594,
0.0008234941633418202,
-0.010339664295315742,
0.0011316854506731033,
-0.0414988175034523,
-0.015425162389874458,
0.00821684580296278,
0.0200283732265234,
0.008536960929632187,
0.021449189633131027,
0.00012802937999367714,
0.004849070217460394,
-0.025401204824447632,
-0.010665422305464745,
0.019826635718345642,
0.008889898657798767,
-0.0001874202862381935,
0.020074710249900818,
-0.03076537698507309,
-0.009898694232106209,
0.013404146768152714,
-0.004810141399502754,
0.0029809721745550632,
-0.022421978414058685,
0.008814599364995956,
-0.008939173072576523,
0.00711886677891016,
-0.004881116561591625,
-0.0056815980933606625,
0.005900610238313675,
0.03730776160955429,
0.001343154115602374,
-0.037063177675008774,
0.01649504154920578,
-0.0025700051337480545,
0.002423096913844347,
0.004990177229046822,
-0.016851812601089478,
0.006522300187498331,
-0.006926120724529028,
-0.000004302244633436203,
-0.0024011745117604733,
-0.003974716179072857,
-0.010610873810946941,
-0.013123719021677971,
0.021184120327234268,
-0.022514525800943375,
0.01649477332830429,
0.01281758677214384,
-0.005037780851125717,
0.013949970714747906,
-0.01295802928507328,
-0.024773987010121346,
0.0008314857259392738,
-0.008405116386711597,
0.0103117935359478,
0.0013727261684834957,
0.02298307605087757,
-0.002462490927428007,
-0.0029771816916763783,
-0.007974091917276382,
-0.009916146285831928,
-0.0029479889199137688,
0.004790285136550665,
-0.006597431376576424,
-0.047838471829891205,
0.00872277282178402,
-0.0030438173562288284,
0.00816754624247551,
-0.005831660702824593,
0.00355071434751153,
0.0008922336855903268,
0.018024876713752747,
0.012267202138900757,
-0.00904359482228756,
-0.007938791066408157,
0.011253898963332176,
0.020609403029084206,
0.012249330058693886,
0.03267030417919159,
-0.0017372434958815575,
0.0006776181980967522,
-0.023431099951267242,
0.0021801854018121958,
0.006576105020940304,
-0.01598607562482357,
0.0017299872124567628,
-0.008985857479274273,
-0.009395373053848743,
0.013852189294993877,
0.012699438259005547,
0.001222739228978753,
0.0044212331995368,
-0.02379174530506134,
-0.006640993990004063,
-0.018659021705389023,
-0.002544723218306899,
-0.0043106526136398315,
0.004003175999969244,
0.0037414226680994034,
0.054302725940942764,
0.005748170427978039,
0.01969199627637863,
0.0722721740603447,
-0.0005785266403108835,
-0.010152162984013557,
-0.022347450256347656,
0.020918969064950943,
-0.013738702982664108,
0.009657403454184532,
0.02813820168375969,
-0.025152578949928284,
0.0005052124615758657,
0.010856563225388527,
0.026710398495197296,
0.010521670803427696,
-0.012152556329965591,
-0.016081176698207855,
0.005755008198320866,
-0.016245989128947258,
0.0117443036288023,
-0.021185018122196198,
0.0015269946306943893,
0.001771773211658001,
-0.015305022709071636,
-0.015340540558099747,
0.005492935888469219,
0.023486454039812088,
-0.015625257045030594,
-0.03434719517827034,
-0.011567071080207825,
0.004437432158738375,
0.0026596197858452797,
0.018613841384649277,
0.046318911015987396,
-0.005145039409399033,
-0.0044496930204331875,
-0.018928980454802513,
0.018327197059988976,
-0.00460772542282939,
0.0175581444054842,
0.018751949071884155,
0.004416922107338905,
0.004362962208688259,
-0.007471664808690548,
0.009757480584084988,
0.012472180649638176,
-0.0070998044684529305,
-0.01534282136708498,
0.012102263048291206,
-0.009107107296586037,
-0.012748008593916893,
0.006344214081764221,
0.005490830633789301,
0.002039002487435937,
0.01306900940835476,
0.04052436724305153,
-0.0224832184612751,
-0.007860022597014904,
0.0037700319662690163,
-0.015972822904586792,
-0.004659899976104498,
-0.03410065174102783,
-0.0009323195554316044,
0.025344494730234146,
0.008104449138045311,
0.025838755071163177,
0.004062590189278126,
-0.01346574630588293,
-0.010009408928453922,
0.01589394547045231,
-0.013727391138672829,
-0.021989449858665466,
0.018038710579276085,
-0.009067188948392868,
-0.008197654038667679,
-0.022352294996380806,
-0.03267471492290497,
-0.0028729289770126343,
-0.017483500763773918,
0.028924738988280296,
0.006572603713721037,
-0.008544797077775002,
-0.01485246792435646,
-0.028526557609438896,
-0.011098762974143028,
0.000841513043269515,
0.04586559534072876,
-0.0038712890818715096,
-0.018077746033668518,
-0.07405370473861694,
0.01366526260972023,
-0.03577917814254761,
-0.012608153745532036,
0.02896065264940262,
0.003309565596282482,
-0.014381298795342445,
0.032654959708452225,
-0.014127381145954132,
-0.006074529606848955,
-0.003574137343093753,
-0.011282401159405708,
0.00228120107203722,
0.0012041147565469146,
0.013703031465411186,
-0.00938823726028204,
-0.007008303422480822,
0.012689998373389244,
-0.016428546980023384,
0.004037426318973303,
-0.033759620040655136,
0.042400795966386795,
0.01290502306073904,
-0.00848456472158432,
-0.010428758338093758,
-0.08152160048484802,
-0.0032756070140749216,
-0.014423114247620106,
0.0017460845410823822,
-0.026933226734399796,
-0.003130736295133829,
0.023695677518844604,
-0.003972804173827171,
-0.031791094690561295,
-0.01533307321369648,
-0.0136735700070858,
-0.0053306203335523605,
0.0009160430636256933,
-0.011983297765254974,
0.03673693537712097,
0.001486737048253417,
0.00001963350223377347,
0.013519994914531708,
0.006760860793292522,
0.0020033330656588078,
-0.006931628566235304,
0.025440644472837448,
-0.005113563966006041,
0.02198255993425846,
-0.006961675360798836,
0.009137636050581932,
-0.009172866120934486,
0.01005595363676548,
0.03500176966190338,
0.015354324132204056,
-0.012705087661743164,
-0.022664044052362442,
-0.022623345255851746,
0.023769281804561615,
-0.0220175813883543,
-0.01726819947361946,
0.004208276513963938,
-0.03440820053219795,
-0.017197923734784126,
-0.01427299715578556,
-0.0033437376841902733,
0.0009673768654465675,
-0.023937154561281204,
-0.010449200868606567,
-0.014176895841956139,
0.009662372060120106,
0.00797114335000515,
0.0004028244875371456,
0.0006190452259033918,
-0.029821094125509262,
0.007397335022687912,
0.0023631928488612175,
0.006179786287248135,
-0.0038924054242670536,
-0.008945713751018047,
0.011543627828359604,
-0.007066453341394663,
0.022175131365656853,
0.020757798105478287,
-0.00385117344558239,
-0.01044125109910965,
0.021597281098365784,
0.022316187620162964,
0.07213980704545975,
-0.05286972597241402,
0.012524298392236233,
0.0052672987803816795,
0.0024650408886373043,
0.0023299758322536945,
-0.022121628746390343,
-0.0017067546723410487,
-0.03516451269388199,
0.008985372260212898,
0.001695415936410427,
-0.018858108669519424,
0.03391028940677643,
0.014376170933246613,
-0.002314012497663498,
0.017996028065681458,
0.012403836473822594,
-0.004163303412497044,
0.016001813113689423,
-0.006322870962321758,
0.04673059657216072,
-0.0014971932396292686,
-0.025929618626832962,
0.014361764304339886,
0.039784304797649384,
-0.024127446115016937,
0.009920207783579826,
0.04188266023993492,
-0.010762583464384079,
0.029614541679620743,
-0.019251061603426933,
0.008991573005914688,
0.005594337824732065,
0.0010897843167185783,
-0.00470613082870841,
0.005198180675506592,
0.0007955096662044525,
0.0017958084354177117,
-0.01581420563161373,
0.019159356132149696,
0.04855843260884285,
-0.02649727836251259,
-0.006410485133528709,
-0.02112814411520958,
0.015612071380019188,
0.013447064906358719,
0.00792248360812664,
-0.017076127231121063,
-0.009156005457043648,
0.003429459873586893,
-0.036815181374549866,
0.0008677253499627113,
-0.013967938721179962,
0.012204758822917938,
0.014938920736312866,
0.004794287029653788,
0.030395738780498505,
0.006925512105226517,
0.005354480352252722,
-0.003527973312884569,
0.008659361861646175,
-0.00550525076687336,
0.014042605645954609,
-0.005857064388692379,
0.019717730581760406,
0.004561617039144039,
-0.0012014068197458982,
-0.0007044064113870263,
-0.0063488297164440155,
0.00594974122941494,
0.01321607269346714,
0.009573159739375114,
0.003091396763920784,
-0.01260506734251976,
0.022374629974365234,
0.008245358243584633,
0.0003593647852540016,
-0.03928236663341522,
-0.00583586934953928,
0.004085528198629618,
-0.009736292064189911,
0.025704234838485718,
-0.012786763720214367,
-0.0027244435623288155,
0.0031129440758377314,
0.018273014575242996,
0.009143437258899212,
-0.01501403097063303,
-0.006011806428432465,
0.0011696380097419024,
-0.0032014157623052597,
0.009987929835915565,
0.001853253343142569,
-0.004654592834413052,
0.006611756049096584,
0.03351936861872673,
0.013594521209597588,
0.027856191620230675,
-0.02656444162130356,
0.012330551631748676,
0.00450458750128746,
-0.008001221343874931,
0.011998260393738747,
0.015175962820649147,
-0.005326757673174143,
0.008585497736930847,
0.029835470020771027,
0.009741568006575108,
0.01843680441379547,
0.02571170963346958,
-0.0399586521089077,
-0.0369010753929615,
0.017018239945173264,
-0.003502817824482918,
0.009494790807366371,
-0.0013044264633208513,
0.022395901381969452,
0.008689172565937042,
-0.016097499057650566,
-0.014259818941354752,
0.016407771036028862,
-0.005958138965070248,
0.0065397657454013824,
0.0035061738453805447,
0.03388898819684982,
0.0017994677182286978,
-0.003980403766036034,
0.01065375842154026,
-0.000309942988678813,
-0.00044911843724548817,
0.015217447653412819,
-0.017661454156041145,
0.006937551312148571,
0.017453785985708237,
-0.007783293724060059,
-0.03407638147473335,
0.014328883960843086,
0.01882605254650116,
0.004572808742523193,
-0.02551453188061714,
0.02290605753660202,
-0.024319954216480255,
0.01191689819097519,
-0.02249774895608425,
0.007385819219052792,
0.019613318145275116,
0.0037750951014459133,
0.00012407870963215828,
0.0030131470412015915,
-0.012691263109445572,
0.024630550295114517,
0.005005281884223223,
-0.011848049238324165,
-0.003480627667158842,
-0.030994858592748642,
0.01968187466263771,
0.0037360454443842173,
0.02663498744368553,
-0.004151581786572933,
-0.013302944600582123,
0.01017207931727171,
0.024041812866926193,
-0.010706622153520584,
0.010068719275295734,
-0.009547113440930843,
0.017835304141044617,
-0.0022744659800082445,
0.01225230097770691,
-0.006351616233587265,
-0.014119818806648254,
0.0061414409428834915,
-0.002812910359352827,
-0.016279034316539764,
0.01662081852555275,
-0.012164714746177197,
-0.007194490171968937,
0.005431010387837887,
0.0025124421808868647,
0.01032823696732521,
0.002235220745205879,
0.02814711630344391,
0.004869351163506508,
-0.0010193148627877235,
-0.0119724590331316,
-0.012552917934954166,
0.00776604562997818,
0.00018553785048425198,
-0.0028807627968490124,
0.009500037878751755,
0.007134732790291309,
0.011577998287975788,
-0.029490437358617783,
0.0009383673314005136,
0.0008911691838875413,
0.03247670829296112,
0.0061636026948690414,
0.019209206104278564,
-0.020424198359251022,
0.004562748596072197,
-0.02290678210556507,
-0.006030630320310593,
-0.019237907603383064
] | [
-0.28994402289390564,
-0.15627580881118774,
0.10566597431898117,
0.04750185087323189,
0.20685334503650665,
0.6539691090583801,
0.315561443567276,
0.17234335839748383,
-0.40981999039649963,
-1.152164340019226,
-0.08235155045986176,
0.14785075187683105,
-0.23901712894439697,
-0.10060934722423553,
-0.08580225706100464,
0.5547524094581604,
0.6713548302650452,
0.6962233781814575,
-0.5900110006332397,
-0.23715215921401978,
-0.1484851986169815,
-0.2739872336387634,
0.6655582785606384,
-0.27444031834602356,
-0.150034099817276,
-0.4148443341255188,
0.22650060057640076,
-0.04883326590061188,
0.27429983019828796,
-0.07213280349969864,
0.21289603412151337,
0.5792849659919739,
0.3268750309944153,
-0.20419937372207642,
0.3193112015724182,
0.13485172390937805,
0.049013908952474594,
-0.19579948484897614,
0.2994624674320221,
-0.09429069608449936,
-0.2174805998802185,
0.007613694295287132,
0.06857799738645554,
0.7001233696937561,
-0.18325521051883698,
-0.10773856192827225,
-1.1318180561065674,
0.21066126227378845,
-0.33818408846855164,
-0.13095977902412415,
0.4608786702156067,
0.19186536967754364,
0.10601683706045151,
0.5681291222572327,
0.29274627566337585,
-0.2898596525192261,
-1.148867130279541,
-0.1308477371931076,
0.38768160343170166,
-0.18043415248394012,
0.6371591687202454,
-0.18962523341178894,
-0.1856042891740799,
-0.3234024941921234,
-0.4428878724575043,
0.2709420621395111,
-0.06110648438334465,
0.39303967356681824,
-0.34546995162963867,
0.21623946726322174,
0.22735245525836945,
-0.17435121536254883,
-0.01744423247873783,
0.391304612159729,
0.1566621959209442,
0.11035426706075668,
-0.14310236275196075,
0.027846001088619232,
0.03894929587841034,
-0.13703371584415436,
-0.02903532050549984,
0.07071450352668762,
0.3114369511604309,
0.4576137065887451,
0.00926391314715147,
0.2789182960987091,
-0.15294954180717468,
0.8327745199203491,
-0.19551709294319153,
0.5517383217811584,
0.010647471994161606,
0.15068195760250092,
0.5388915538787842,
-0.07352536916732788,
-0.43860292434692383,
0.3560633063316345,
0.0069611226208508015,
-0.08106983453035355,
0.5099124312400818,
-0.27053579688072205,
-0.005644361488521099,
-0.1846579909324646,
-0.0994451493024826,
-0.1751888543367386,
-0.0236730445176363,
-0.10345795750617981,
0.19433873891830444,
-0.12802402675151825,
0.09612396359443665,
-0.24422697722911835,
-1.0551170110702515,
-0.01923738606274128,
-0.41411635279655457,
-0.2762064039707184,
-0.4529199004173279,
0.4608815014362335,
-0.22117511928081512,
-0.40391701459884644,
-0.4713287353515625,
-0.5602236986160278,
-0.30934977531433105,
0.03104708157479763,
0.37358373403549194,
0.20407350361347198,
0.37219199538230896,
0.20730333030223846,
0.2472025454044342,
0.09647751599550247,
0.3024067282676697,
0.5870409607887268,
0.3119080662727356,
-0.004069646820425987,
-0.15282179415225983,
-0.11871831864118576,
-0.06511776149272919,
0.060818348079919815,
0.16777357459068298,
0.24336548149585724,
0.3744961619377136,
0.19818828999996185,
-0.2825317680835724,
-0.6596083045005798,
-0.279082328081131,
0.24985520541667938,
0.17588548362255096,
-0.5117049813270569,
0.07281389832496643,
0.16281385719776154,
-0.03801856189966202,
-0.055287670344114304,
-0.06332312524318695,
-0.07981512695550919,
-0.35017040371894836,
-0.2001001089811325,
-0.222936749458313,
0.1056596115231514,
-0.41488832235336304,
-0.3482205271720886,
0.06750570237636566,
0.001310704741626978,
0.355271577835083,
0.11757312715053558,
-0.7176943421363831,
-0.4577477276325226,
0.5723382234573364,
-0.3758614659309387,
0.13322335481643677,
0.09156782925128937,
-0.17770905792713165,
0.9429057240486145,
-0.2319476157426834,
-0.2856300175189972,
-0.19249817728996277,
-0.3800002932548523,
-0.11044446378946304,
0.4495396316051483,
0.2197732925415039,
0.20897960662841797,
0.5103825926780701,
-0.212638720870018,
-0.6668382287025452,
0.33765071630477905,
0.522538423538208,
-0.11831609904766083,
0.10526016354560852,
-0.282033771276474,
0.6649494767189026,
-0.24998360872268677,
-0.3819448947906494,
-0.194399893283844,
-0.025501295924186707,
-0.3787497282028198,
0.7360087037086487,
-0.364177942276001,
1.383765697479248,
-0.17352280020713806,
-0.147751122713089,
0.49727755784988403,
-0.2594190239906311,
-0.1354571133852005,
-0.13398940861225128,
-0.04102242738008499,
0.7449805736541748,
-0.26715853810310364,
-1.0494881868362427,
0.20880372822284698,
-0.17297299206256866,
-0.45678791403770447,
0.11169563233852386,
-0.004637052305042744,
0.5868074893951416,
-0.8173368573188782,
-0.1526595801115036,
-0.23479272425174713,
0.28884389996528625,
-0.14157572388648987,
0.2095625102519989,
0.10507100820541382,
0.12237464636564255,
-0.16102203726768494,
0.6369925737380981,
-0.27993831038475037,
0.5884367227554321,
0.4114576578140259,
0.5135807991027832,
0.17469508945941925,
0.7440321445465088,
0.5510841608047485,
0.5454638600349426,
-0.09611181914806366,
0.06142325699329376,
-0.48898836970329285,
0.39935052394866943,
-0.11370426416397095,
0.19431062042713165,
-0.3136029839515686,
0.034802451729774475,
-0.2510293126106262,
-0.10374389588832855,
-0.3328578472137451,
-0.5174992084503174,
0.4463389813899994,
-0.8258752226829529,
0.11387566477060318,
0.2574898302555084,
-0.6158428192138672,
-0.2679791748523712,
0.6201122403144836,
-0.8715835213661194,
-0.21628183126449585,
-0.21791359782218933,
0.8828663229942322,
0.04410853609442711,
-0.4305447041988373,
-0.1874316930770874,
-0.08998948335647583,
0.31154966354370117,
0.01244774553924799,
0.1453809142112732,
-0.5423606634140015,
-0.43542683124542236,
0.07732214033603668,
0.4423605501651764,
-0.11536550521850586,
-0.4034738540649414,
-0.2874615490436554,
-0.7799336314201355,
-0.8622294664382935,
0.4545665383338928,
0.42442023754119873,
1.3610957860946655,
0.14966987073421478,
-0.9125561714172363,
-0.28766629099845886,
-0.379580020904541,
-0.528299868106842,
0.4514593482017517,
0.5141443610191345,
-0.7269216179847717,
-0.2555982172489166,
-0.01998865231871605,
0.5986450910568237,
0.845492422580719,
0.14756712317466736,
-0.24707694351673126,
-0.059011392295360565,
0.23674793541431427,
-0.3174018859863281,
-0.3492576479911804,
-0.4413255751132965,
-0.4736361801624298,
1.1412104368209839,
-0.271774023771286,
-0.22888635098934174,
0.8225395679473877,
-0.022933004423975945,
-0.1327008605003357,
0.2335740178823471,
0.7520007491111755,
-0.39963820576667786,
0.20982761681079865,
0.14126019179821014,
0.17416979372501373,
0.028758199885487556,
-0.07206158339977264,
0.0068697077222168446,
0.10497869551181793,
0.22847914695739746,
-5.75842809677124,
-0.08214634656906128,
-0.2011389285326004,
-0.1528567522764206,
0.06307440251111984,
-0.1945396363735199,
1.221112608909607,
0.09114851802587509,
0.10956884175539017,
0.23609614372253418,
0.2765859365463257,
0.3694281280040741,
0.11445572227239609,
-0.04295162111520767,
-0.3589969277381897,
-0.0508572943508625,
-0.23504561185836792,
-0.03076816163957119,
0.31560268998146057,
-0.006363532040268183,
0.5010337829589844,
-0.5678163170814514,
-0.14565928280353546,
0.6838440895080566,
0.0890347957611084,
0.13207308948040009,
-0.6715980768203735,
0.381863534450531,
-0.7020348310470581,
-0.6347024440765381,
0.1274259388446808,
-0.49632638692855835,
0.2365933358669281,
-0.4317994713783264,
0.2591390907764435,
-0.44984835386276245,
-0.002398180076852441,
0.369712233543396,
-0.13869526982307434,
0.09735273569822311,
-0.16164769232273102,
0.06783674657344818,
-0.30275893211364746,
-0.21419069170951843,
0.5015566349029541,
0.2388862520456314,
0.26144057512283325,
-0.04547237232327461,
0.1682981252670288,
0.711768627166748,
0.19465100765228271,
-0.4940979480743408,
-0.09848730266094208,
0.5208167433738708,
0.5039097666740417,
0.37394973635673523,
0.0924157127737999,
0.5445669293403625,
0.09232784807682037,
0.2518192529678345,
-0.09931514412164688,
-0.23113274574279785,
-0.19259995222091675,
-0.8726298213005066,
-0.2197825014591217,
0.23196086287498474,
-0.49529141187667847,
0.052637942135334015,
0.40960901975631714,
0.16419173777103424,
-0.08454510569572449,
0.40510162711143494,
0.669139564037323,
-0.9009475708007812,
0.5424265265464783,
-0.7056025266647339,
-0.039263252168893814,
0.3393460810184479,
-0.47400805354118347,
-0.19194819033145905,
-0.07268517464399338,
-0.21590177714824677,
-0.26592400670051575,
0.5368533134460449,
0.9100552797317505,
-0.6700119972229004,
-0.3068937659263611,
-0.15116970241069794,
0.4059719741344452,
0.14230282604694366,
0.6010969281196594,
-0.35670316219329834,
0.17063724994659424,
0.011113348416984081,
-0.03373876214027405,
0.3319774866104126,
0.13430608808994293,
0.5249626636505127,
0.11245723068714142,
0.018456578254699707,
0.6559386253356934,
-0.22790366411209106,
-0.2771281599998474,
-0.3417241871356964,
-0.19467036426067352,
0.4496605694293976,
-0.334375262260437,
0.2793596088886261,
0.5049587488174438,
-0.7828287482261658,
0.1482084095478058,
-0.3483017683029175,
-0.9062805771827698,
-0.6982651948928833,
0.1684219092130661,
-0.24041947722434998,
-0.49717727303504944,
0.18344081938266754,
0.5868749618530273,
0.07692809402942657,
-0.2286604642868042,
0.2474869340658188,
-0.5754140019416809,
-0.1626497060060501,
0.5224074721336365,
-0.05244683474302292,
0.27556052803993225,
0.43373072147369385,
-0.20666362345218658,
0.10688656568527222,
-0.14985841512680054,
0.7335983514785767,
0.034331437200307846,
0.10767613351345062,
0.11604021489620209,
-0.27721554040908813,
-0.058921027928590775,
0.5978388786315918,
0.14942564070224762,
-0.3045918345451355,
0.27075693011283875,
0.10614107549190521,
-0.2756829559803009,
0.006894934456795454,
0.20670023560523987,
0.0893767923116684,
-0.03935197368264198,
0.025068189948797226,
-0.4256221055984497,
0.27089759707450867,
0.43125060200691223,
0.17337526381015778,
0.20823995769023895,
0.15492066740989685,
-0.513069748878479,
0.3082599341869354,
0.10478180646896362,
0.5343170166015625,
-0.20352156460285187,
-0.6775558590888977,
0.3534994423389435,
-0.6950669884681702,
-0.9014030694961548,
-0.33035439252853394,
-0.4249783456325531,
0.053357649594545364,
-0.00394780607894063,
-0.42697903513908386,
-0.12564553320407867,
0.18471956253051758,
-0.4284018874168396,
-0.6248535513877869,
0.20862586796283722,
-0.29163700342178345,
0.04723042622208595,
-0.2423890233039856,
-0.41780808568000793,
-0.14107735455036163,
-0.043518517166376114,
0.030011290684342384,
-0.26726827025413513,
-0.4191473722457886,
0.24448245763778687,
0.3015037477016449,
0.47837716341018677,
-0.10051378607749939,
0.07522469013929367,
0.38204464316368103,
-0.3139844238758087,
-0.36103129386901855,
0.19856379926204681,
-0.1425568163394928,
0.15761250257492065,
-0.25370386242866516,
0.7045384049415588,
0.2198942005634308,
0.2755436897277832,
0.5461933612823486,
0.06146537885069847,
0.03264562413096428,
-0.26183921098709106,
0.21932432055473328,
-0.15556779503822327,
0.6141780018806458,
1.0424034595489502,
0.12919387221336365,
-0.36434808373451233,
0.08592655509710312,
-0.7077154517173767,
-0.3747382164001465,
-1.149656057357788,
-0.7896677255630493,
-0.004446316976100206,
0.43767163157463074,
-0.4366935193538666,
0.19479525089263916,
-0.041646815836429596,
-0.3953547179698944,
0.1867944300174713,
0.1474214494228363,
0.40700703859329224,
0.20691393315792084,
-0.3426905870437622,
-0.032706212252378464,
0.039686113595962524,
0.20804229378700256,
0.7229027152061462,
-0.4764411151409149,
0.6414300799369812,
-0.1989087164402008,
-0.2977901101112366,
0.13257455825805664,
0.09592875838279724,
0.0008092522039078176,
-0.323632150888443,
-0.35019707679748535,
0.06783105432987213,
0.1154773086309433,
0.19323424994945526,
0.43288373947143555,
0.01423121802508831,
0.7347516417503357,
-0.05563108250498772,
-0.2879740595817566,
0.1399458944797516,
0.3998156189918518,
0.6308223009109497,
-0.9584240317344666,
-0.16576653718948364,
0.1826055347919464,
0.300489217042923,
-0.26760250329971313,
-0.11850153654813766,
-0.2478223592042923,
0.4239977300167084,
-0.09467227011919022,
-0.25350314378738403,
-0.7263031601905823,
0.0798896849155426,
0.144052654504776,
-0.09603903442621231,
0.11122450232505798,
0.31626391410827637,
0.1710766702890396,
-0.037804070860147476,
-0.09236035495996475,
-0.2713966369628906,
-0.3821388781070709,
0.3662782311439514,
-0.1240215003490448,
0.42884543538093567,
-0.36582398414611816,
0.3564194142818451,
0.4098401665687561,
-0.04646136611700058,
0.3722236454486847,
-0.710716962814331,
-0.7050266265869141,
-0.4675029516220093,
0.023494094610214233,
-0.2934904992580414,
-0.5489707589149475,
-0.007105255499482155,
-0.2299998253583908,
0.3448992073535919,
-0.5960412621498108,
-0.02635979652404785,
-0.3682553172111511,
-0.5629854798316956,
0.39896491169929504,
-0.35409966111183167,
0.38849499821662903,
-0.46085792779922485,
-0.600812554359436,
-0.17551545798778534,
0.34483376145362854,
0.2773500382900238,
0.28840142488479614,
-0.45966026186943054,
-0.65141761302948,
-0.41139674186706543,
0.2402687519788742,
0.2818159759044647,
-0.4290497899055481,
0.6252707242965698,
0.29983872175216675,
-0.3930702209472656,
-0.7229681611061096,
-0.007033950183540583,
0.040680546313524246,
0.07921324670314789,
-0.01175643503665924,
0.573792576789856,
0.7108080387115479,
0.038008421659469604,
-0.05589832738041878,
-0.48610424995422363,
-0.020209571346640587,
0.03135896101593971,
0.23283950984477997,
0.26676490902900696,
0.8659218549728394,
0.8589429259300232,
0.04670251905918121,
-0.4719713628292084,
0.3569296598434448,
0.526882529258728,
-0.24089404940605164,
0.006849193945527077,
1.0727794170379639,
0.45649388432502747,
0.14040639996528625,
-0.3456282615661621,
0.5746234059333801,
0.31624674797058105,
0.3630853593349457,
0.0658508837223053,
-0.5141934752464294,
-0.4442477226257324,
0.2145334631204605,
0.7449852228164673,
-0.16431760787963867,
-0.3003690242767334,
0.44695204496383667,
0.026649178937077522,
0.6733087301254272,
0.08529702574014664,
0.07944219559431076,
0.33770158886909485,
-0.3584256172180176,
0.35392600297927856,
-0.7372332811355591,
-0.6465051174163818,
0.17751361429691315,
-0.3780761957168579,
0.8527124524116516,
-0.07525137066841125,
-0.7873758673667908,
-0.44405972957611084,
0.044262006878852844,
-0.1185264140367508,
-0.1430782824754715,
0.050621047616004944,
-0.003939325921237469,
0.15545131266117096,
-0.3996649384498596,
-0.18995384871959686,
-0.09285327047109604,
0.14314556121826172,
0.032602593302726746,
-0.34160923957824707,
-0.01753280498087406,
-0.5101878046989441,
-0.11480513960123062,
0.8055327534675598,
0.08881904184818268,
-0.39234745502471924,
1.0143667459487915,
-0.14878639578819275,
0.02133454941213131,
-0.7798757553100586,
-0.09782180190086365,
-0.648997962474823,
-0.24291621148586273,
0.005783732049167156,
0.15587671101093292,
-0.17546622455120087,
-0.3919874429702759,
-0.022873589769005775,
0.19174355268478394,
0.1681797057390213,
-0.1295819729566574,
0.8524340987205505,
-0.22181808948516846,
0.08762077242136002,
-0.34921690821647644,
0.1435362845659256,
0.09150293469429016,
0.43567878007888794,
-0.04717300087213516,
-0.05491219460964203,
-0.2310435026884079,
-0.3752443492412567,
0.24186691641807556,
-0.48716261982917786,
0.7610974907875061,
0.024459125474095345,
0.19715197384357452,
-0.7727016806602478,
-0.02072514034807682,
0.6971936225891113,
0.43123525381088257,
0.13906341791152954,
0.7599405646324158,
0.6377299427986145,
0.035950105637311935,
0.24032162129878998,
-0.6120148301124573,
-0.616199791431427,
-0.7487848997116089,
0.1302034854888916,
-0.8331394791603088,
0.8914486169815063,
0.008693080395460129,
0.08308374136686325,
0.29179298877716064,
0.46747711300849915,
0.1470598727464676,
-0.29459160566329956,
0.25055620074272156,
-0.6953978538513184,
0.4410645365715027,
-0.6326746940612793,
0.09837731719017029,
-0.42833974957466125,
0.12100031226873398,
0.2037777453660965,
-0.058424871414899826,
-0.21250616014003754,
0.04197824373841286,
0.01082522887736559,
-0.8792316913604736,
-0.26277023553848267,
0.010006634518504143,
0.23005035519599915,
0.2153739482164383,
0.3160789906978607,
-0.32531365752220154,
-0.9107171297073364,
0.14114698767662048,
-0.021564379334449768,
-0.44134196639060974,
0.0647049993276596,
-0.03419569879770279,
-0.21086964011192322,
-0.30876144766807556,
0.18501053750514984,
-0.21335268020629883,
-0.33167564868927,
-0.2787051200866699
] |
As more is learned about the development of cervical cancer, the value of annual Pap smear screening for all women is being questioned. This study was conducted to investigate whether women at higher risk for the development of cervical cancer could be identified by testing for the presence of human papillomavirus (HPV) in the cervical smear. These women could be followed annually, and the interval between screening Pap smears for women at lower risk could be increased. Study participants were women enrolled in the Kaiser Permanente healthcare plan in Portland, Oregon, who underwent annual Pap smear screening between April 1989, and November 1990. More than 20,000 women (20,810 of 23,702) had satisfactory cervical smears with sufficient samples for HPV testing, which was conducted using a polymerase chain reaction-based method with MYO9/11 primers. Most women (83.6%) had at least one follow-up smear during the study period; however, women with atypical squamous cells (ASC) or worse had more smears than women with normal results (mean, 4.4 vs. 3.3). Follow-up was conducted more or less annually for a total period of 122 months. HPV results were not used in deciding patient management. Ninety-six percent of the 20,810 baseline Pap smears were diagnosed as negative (N = 20,156). Thirteen percent of these patients tested positive for HPV. The baseline smears of 654 of the 20,810 women (3.1%) were classified as ASC or worse. Of these 654 smears, 417 (63.8%) were positive for HPV. One hundred seventy-eight women had a cytologic diagnosis of a low-grade squamous intraepithelial lesion or worse; of these, 143 (80.3%) tested positive for HPV. During the 10 years of follow-up, 171 patients developed cervical intraepithelial neoplasia (CIN) 3 or cervical cancer. The baseline smear was normal in 112 of these women and ASC or worse in 59 (34.5%). Only half (49.2%) of the 58 patients diagnosed within the first 45 months of follow-up had an abnormal baseline smear. During this first 45 months, 7.85% of the women whose initial Pap test was at least ASC were diagnosed with CIN 3 or cancer. The cumulative incidence at 10 years of follow-up was 10.2%. Sixty of the 171 women with CIN 3 or cervical cancer had a negative baseline HPV test. Of the 118 women who were diagnosed during the first 45 months of follow-up, 89 (79.4%) were HPV positive initially. The cumulative incidence of CIN 3 or cancer among the group with a positive baseline HPV test was 6.92% over 10 years but only 1.73% at 45 months. The risk of developing CIN 3 or cancer remained elevated throughout the study in those women with a positive baseline HPV test. The predictive ability of the baseline Pap smear diminished as the follow-up interval increased. Fifteen percent of the patients (N = 3216) had a positive Pap smear, a positive HPV test, or both at the initial examination. One hundred twenty-three (71.9%) were among the 171 women who developed CIN 3 or cancer. Eighty-six percent (102 of 123) of the patients who were diagnosed within the first 45 months were positive with at least one of the screening studies. The cumulative incidence over 45 months for women who had positive HPV testing and/or abnormal Pap smear results was 4.54%. Women with negative results in both screening tests had a cumulative risk of 0.16% for the same period. At 10 years the cumulative risk incidence for these two groups was 6.83% and 0.79%, respectively, yielding a negative predictive value of 99.1% for combined testing. | [
-0.004039865452796221,
0.013665224425494671,
-0.005612858571112156,
0.018937360495328903,
0.031284842640161514,
0.02151821181178093,
0.010119147598743439,
-0.011596336029469967,
-0.0137693015858531,
-0.015091462060809135,
0.0036287251859903336,
0.0023787503596395254,
-0.012861734256148338,
0.005675534717738628,
0.0265793576836586,
-0.024200282990932465,
-0.020197223871946335,
-0.016432344913482666,
0.004316766280680895,
0.017181281000375748,
0.02933800406754017,
-0.020679494366049767,
0.009446775540709496,
-0.013923672027885914,
-0.0023177890107035637,
-0.006933176890015602,
-0.00029509514570236206,
-0.04393564909696579,
-0.010083911009132862,
-0.020325101912021637,
-0.01905694045126438,
-0.020055873319506645,
0.013657789677381516,
0.014049275778234005,
-0.0010420432081446052,
-0.021127181127667427,
0.0029473830945789814,
0.029600780457258224,
-0.0018370551988482475,
-0.0015355254290625453,
-0.009340026415884495,
-0.010861771181225777,
0.010067246854305267,
-0.006003902293741703,
-0.00554956728592515,
0.008842675015330315,
-0.003973533399403095,
-0.0006047110073268414,
0.008631703443825245,
0.006394146475940943,
-0.005204368382692337,
0.018473468720912933,
-0.01504712924361229,
0.001737785991281271,
-0.007081737741827965,
0.01481768861413002,
0.01758940890431404,
0.01659402996301651,
0.006061810068786144,
-0.011573933996260166,
-0.016517266631126404,
-0.04510023817420006,
0.02438012883067131,
-0.005629979074001312,
-0.033268705010414124,
-0.0671006441116333,
0.013410037383437157,
-0.004863553214818239,
0.004487986676394939,
0.0036204317584633827,
0.01791049912571907,
0.01211037952452898,
0.030157512053847313,
0.02287217043340206,
-0.00628198217600584,
0.000879249069839716,
0.009386593475937843,
-0.0036469437181949615,
0.011951266787946224,
0.0030550239607691765,
0.020232142880558968,
-0.009932741522789001,
0.008682162500917912,
0.005122416187077761,
-0.006968656554818153,
-0.005395232234150171,
-0.014767752960324287,
-0.0008134772069752216,
-0.00241731945425272,
0.004898172803223133,
-0.0011667176149785519,
0.02945379540324211,
-0.05083848536014557,
-0.025827378034591675,
-0.011640709824860096,
-0.023475831374526024,
-0.017128407955169678,
-0.009556571021676064,
0.0009590592235326767,
-0.024613894522190094,
-0.005583955440670252,
-0.0005494104698300362,
0.021927380934357643,
-0.03416929394006729,
0.02099306881427765,
0.012210791930556297,
-0.014326311647891998,
0.004756507929414511,
0.018828941509127617,
0.0066737947054207325,
-0.01626061089336872,
0.007227717898786068,
-0.007013751193881035,
-0.0050497110933065414,
0.006910914555191994,
0.0002491879276931286,
0.0006715538329444826,
0.020338764414191246,
0.006887391675263643,
0.02190004102885723,
-0.03293102607131004,
-0.016441501677036285,
0.005990062840282917,
0.030721180140972137,
-0.0032420174684375525,
-0.000721997581422329,
0.020955368876457214,
0.0006158244796097279,
0.01239786297082901,
-0.011935830116271973,
-0.0034247920848429203,
0.012006748467683792,
0.00488585140556097,
0.0047616735100746155,
-0.0010976595804095268,
0.0004843382630497217,
-0.007207054179161787,
-0.02567063644528389,
-0.01073434203863144,
-0.0031685014255344868,
-0.005256978794932365,
0.00836251676082611,
-0.005402442999184132,
0.008349521085619926,
-0.011423650197684765,
-0.0021187523379921913,
0.0008166839834302664,
0.010644444264471531,
0.006346050649881363,
0.003450700081884861,
0.0027010231278836727,
0.0018593473359942436,
-0.0039897458627820015,
-0.020593687891960144,
-0.025568466633558273,
-0.03638358414173126,
0.0013583870604634285,
0.011416972614824772,
-0.01804194413125515,
-0.035949453711509705,
0.008192576467990875,
-0.0008273140992969275,
0.0012588596437126398,
0.008319154381752014,
-0.0183124803006649,
0.002790997037664056,
-0.013981575146317482,
0.004825989715754986,
-0.0053451526910066605,
0.0003946733777411282,
-0.012135201133787632,
-0.0007555680349469185,
-0.02050454542040825,
0.0031427419744431973,
0.019234338775277138,
-0.0059035480953752995,
0.0564519502222538,
0.007875275798141956,
-0.011154058389365673,
0.06661074608564377,
-0.01818702556192875,
-0.001117632375098765,
-0.024698030203580856,
0.013776089996099472,
0.025845611467957497,
-0.0191506277769804,
-0.013120539486408234,
-0.005926246289163828,
0.021672917529940605,
-0.003915887326002121,
-0.002387848449870944,
-0.02221328765153885,
-0.015440569259226322,
0.0535140335559845,
-0.00490723829716444,
0.005189885385334492,
0.011882456950843334,
0.008297385647892952,
0.0004878768522758037,
-0.0051402258686721325,
0.00840974971652031,
0.008072519674897194,
0.022998549044132233,
-0.0022216695360839367,
-0.00858661811798811,
0.0008202800527215004,
0.022358683869242668,
-0.0010641647968441248,
-0.011355938389897346,
0.016621772199869156,
0.010481669567525387,
0.003320302814245224,
0.00830570887774229,
-0.00395543547347188,
0.025217099115252495,
0.009037887677550316,
0.0007171104662120342,
0.009559551253914833,
-0.03145934268832207,
-0.01724421977996826,
-0.0010653208009898663,
0.025830022990703583,
0.002525252290070057,
0.017277171835303307,
-0.0012597686145454645,
-0.03166697919368744,
0.016440927982330322,
0.006447919644415379,
-0.008962348103523254,
0.012487657368183136,
0.0022404601331800222,
-0.006550082005560398,
-0.005575619172304869,
0.009485247544944286,
0.014338847249746323,
-0.003269508481025696,
0.00577710522338748,
-0.02366897091269493,
0.007404893636703491,
-0.01423212606459856,
0.007282083388417959,
-0.008576028980314732,
0.0023194393143057823,
-0.00820324569940567,
-0.011350955814123154,
0.03370104730129242,
0.016180921345949173,
0.00836779735982418,
0.002846781862899661,
-0.000922773964703083,
0.005223572254180908,
-0.02232038788497448,
0.03259456902742386,
-0.006725838873535395,
0.03226844221353531,
0.004281602334231138,
-0.007983120158314705,
0.027140719816088676,
0.02692977711558342,
-0.02793862856924534,
0.016980132088065147,
0.004362547770142555,
0.014790836721658707,
-0.0457773320376873,
0.02080925926566124,
0.014555748552083969,
0.004360637627542019,
0.0026883818209171295,
0.02220604382455349,
-0.002613558666780591,
0.0045658620074391365,
-0.002354695927351713,
-0.012061991728842258,
-0.08195707947015762,
-0.001919282367452979,
0.004321657121181488,
-0.01638709008693695,
0.00920892134308815,
-0.005322066601365805,
0.003744961228221655,
0.018081625923514366,
-0.0011721872724592686,
-0.011717183515429497,
0.008252139203250408,
0.010991398245096207,
-0.008738143369555473,
0.0045249368995428085,
-0.004373092669993639,
-0.0025748268235474825,
0.000019639788661152124,
0.007989048026502132,
-0.04257683828473091,
-0.02664320170879364,
-0.004272167570888996,
0.03699319064617157,
-0.0025710249319672585,
-0.0037812315858900547,
0.061812128871679306,
0.01377929002046585,
-0.007350447122007608,
0.009216370061039925,
0.010129930451512337,
-0.0010320083238184452,
0.007263276260346174,
0.007097726687788963,
-0.004317917861044407,
-0.016948483884334564,
-0.04160444438457489,
-0.023469192907214165,
-0.016727425158023834,
0.04791494458913803,
-0.02093696966767311,
-0.008784038946032524,
0.002006974071264267,
0.0030467272736132145,
0.003661594120785594,
-0.0027945376932621002,
0.00901423767209053,
0.012287715449929237,
0.012910732999444008,
0.04411577433347702,
0.012018152512609959,
-0.00737638957798481,
0.01591338962316513,
-0.0009190505370497704,
-0.002328634960576892,
0.005685360170900822,
-0.009541355073451996,
-0.0008544507436454296,
-0.0036340435035526752,
0.0031384993344545364,
-0.012860608287155628,
-0.007862710393965244,
0.02181098610162735,
-0.029212098568677902,
0.004567059688270092,
0.04548684507608414,
-0.003469967283308506,
0.0035910008009523153,
0.0024613644927740097,
-0.004669285845011473,
-0.011320628225803375,
0.012412695214152336,
0.019924286752939224,
-0.039940595626831055,
-0.008950960822403431,
0.001695509534329176,
0.021642886102199554,
-0.010903271846473217,
-0.012373020872473717,
-0.002322416752576828,
-0.009910279884934425,
0.030264291912317276,
-0.0018744212575256824,
-0.0008669623639434576,
0.0005194596014916897,
0.008566761389374733,
0.004154357127845287,
0.0662575364112854,
0.017772788181900978,
0.008871029131114483,
0.0050358846783638,
-0.01946425624191761,
-0.0025396416895091534,
0.020328909158706665,
0.017866354435682297,
0.006798265036195517,
0.017463674768805504,
-0.006679951678961515,
0.014944568276405334,
0.010758992284536362,
0.018015747889876366,
0.009542843326926231,
-0.005648592486977577,
0.00044937554048374295,
0.015870044007897377,
-0.00773080438375473,
-0.029471173882484436,
0.01398879662156105,
0.016262497752904892,
-0.019030170515179634,
-0.02099478989839554,
-0.015431206673383713,
-0.014448105357587337,
-0.0026474662590771914,
-0.009575821459293365,
-0.0016495289746671915,
0.006530357990413904,
-0.010187855921685696,
0.014202463440597057,
0.008071038872003555,
0.07206279039382935,
-0.017950300127267838,
0.012375718913972378,
-0.006749858148396015,
-0.030701853334903717,
-0.021213684231042862,
0.0027292738668620586,
0.003311807755380869,
0.02552708238363266,
0.005915503948926926,
0.014043277129530907,
-0.014187118038535118,
-0.007287405896931887,
-0.03335936367511749,
0.01844838820397854,
0.013305151835083961,
0.015044866129755974,
0.012586808763444424,
0.0023186765611171722,
0.00834077037870884,
-0.027518566697835922,
0.010906380601227283,
-0.011926349252462387,
-0.007038804702460766,
0.014077753759920597,
-0.01301658060401678,
-0.001592479646205902,
-0.013732034713029861,
-0.021603701636195183,
-0.003875640220940113,
-0.0003578073810786009,
-0.00020126858726143837,
0.0009828517213463783,
0.009566323831677437,
-0.0033653993159532547,
-0.0021916236728429794,
-0.015075387433171272,
0.022827841341495514,
-0.004873695317655802,
-0.01015063188970089,
-0.00311304465867579,
-0.015669211745262146,
0.007084978744387627,
0.015112696215510368,
-0.015748441219329834,
0.013533593155443668,
-0.010583522729575634,
-0.0058317421935498714,
-0.0016183117404580116,
0.0076806871220469475,
-0.00862602423876524,
-0.006743503734469414,
0.00753967696800828,
0.0004089539870619774,
-0.0054842825047671795,
0.014964170753955841,
-0.006367919966578484,
-0.010421421378850937,
-0.020513352006673813,
0.007532712537795305,
-0.0019922503270208836,
-0.023797964677214622,
0.013971873559057713,
0.015640482306480408,
-0.01005659531801939,
-0.01170351728796959,
-0.015940159559249878,
-0.015399977564811707,
-0.002178807742893696,
-0.032534074038267136,
-0.012837613932788372,
-0.022287700325250626,
-0.013494878076016903,
-0.03400016203522682,
-0.024185486137866974,
0.004094899166375399,
0.003747094888240099,
-0.01081974059343338,
-0.02788524329662323,
-0.028524745255708694,
0.006375833414494991,
-0.03208855167031288,
0.016121260821819305,
0.00989188626408577,
-0.0003742249682545662,
0.01779305748641491,
-0.0017522475682199001,
-0.07503027468919754,
-0.013293717987835407,
-0.018183059990406036,
-0.013266206718981266,
-0.014750970527529716,
0.013181942515075207,
-0.01056160032749176,
-0.002548220567405224,
-0.008659852668642998,
-0.0003995914594270289,
-0.003387436270713806,
-0.006616109982132912,
0.02394281141459942,
-0.007983025163412094,
0.016072247177362442,
0.0038126353174448013,
-0.000111074885353446,
-0.007685012649744749,
-0.0024856585077941418,
-0.009393030777573586,
0.04560022056102753,
0.0062051499262452126,
0.009032065980136395,
-0.013417938724160194,
0.00029260211158543825,
-0.08105583488941193,
0.011433418840169907,
-0.002739617833867669,
-0.034102898091077805,
-0.009485682472586632,
-0.0046548000536859035,
0.034589529037475586,
-0.0032345151994377375,
-0.02126656286418438,
-0.01726256124675274,
-0.022820767015218735,
-0.003965657204389572,
0.006172890309244394,
0.016942186281085014,
0.006082470063120127,
-0.012302663177251816,
0.01210770569741726,
-0.002202466130256653,
-0.010055708698928356,
0.015452427789568901,
-0.005350053310394287,
0.02434982918202877,
-0.007057701237499714,
0.0012272975873202085,
-0.011789076030254364,
-0.00239940220490098,
-0.01062796637415886,
0.010933548212051392,
0.005057872273027897,
-0.018838414922356606,
-0.016059881076216698,
-0.02836785838007927,
-0.0014088598545640707,
-0.001210994552820921,
0.011989634484052658,
-0.008729877881705761,
0.00957075972110033,
-0.008300792425870895,
-0.003947369754314423,
-0.008837931789457798,
-0.005011858884245157,
0.03298266977071762,
-0.01115549635142088,
-0.0073428163304924965,
-0.021051887422800064,
-0.02265464887022972,
0.007132680155336857,
-0.0015967708313837647,
0.007369810249656439,
0.0035152644850313663,
0.00742647610604763,
-0.003359696827828884,
-0.008845789358019829,
-0.014639070257544518,
0.001416682032868266,
-0.007866092026233673,
-0.000514350482262671,
0.003777659498155117,
-0.006319784093648195,
-0.005442427005618811,
-0.00858361180871725,
0.0003663769457489252,
-0.024143343791365623,
0.07158274948596954,
-0.002881084568798542,
0.008275572210550308,
-0.014757001772522926,
0.00407146941870451,
-0.0001691170036792755,
-0.01191698294132948,
-0.020732441917061806,
0.01220986619591713,
-0.01919381320476532,
-0.008603233844041824,
0.002731194719672203,
0.020424021407961845,
0.0026708708610385656,
-0.021044697612524033,
-0.00246001360937953,
-0.002739592920988798,
0.015064935199916363,
0.007279295474290848,
-0.026225373148918152,
0.006857382133603096,
0.03391916677355766,
-0.0249208714812994,
-0.01910926029086113,
0.02028588578104973,
0.0008838002104312181,
-0.04889925196766853,
-0.00870207604020834,
-0.006111518479883671,
-0.01259519625455141,
0.015833720564842224,
0.0068810200318694115,
0.007547928486019373,
0.03243015706539154,
-0.0011920480756089091,
-0.004041609354317188,
0.008677768521010876,
-0.003531754482537508,
0.01787896268069744,
0.009900505654513836,
0.03149448707699776,
-0.015139482915401459,
-0.0004481473006308079,
-0.02045980468392372,
0.032061830163002014,
-0.007908793166279793,
-0.0008842370007187128,
-0.023690827190876007,
0.022745169699192047,
0.015892695635557175,
0.01421317271888256,
0.017845267429947853,
0.0037614882458001375,
-0.01658906415104866,
-0.0007619484094902873,
-0.016007306054234505,
0.006637651473283768,
0.020119015127420425,
0.047541700303554535,
0.003486349480226636,
0.022892476990818977,
-0.018712002784013748,
-0.009326781146228313,
-0.015720076858997345,
0.00559617206454277,
0.01048460602760315,
0.00960120465606451,
-0.017661090940237045,
-0.016724392771720886,
0.017993386834859848,
-0.00018316018395125866,
-0.0032158836256712675,
0.0024214498698711395,
-0.01673569530248642,
-0.009249314665794373,
0.017394347116351128,
0.034371595829725266,
0.008742778562009335,
-0.004978896118700504,
0.014133448712527752,
-0.019216742366552353,
0.02265353873372078,
0.00722168106585741,
0.014208908192813396,
-0.011929979547858238,
0.0013313193339854479,
-0.0024541416205465794,
0.0007161942776292562,
-0.017840303480625153,
0.003933591768145561,
-0.015170590952038765,
0.02087029069662094,
-0.007325573358684778,
0.010192648507654667,
0.004578819964081049,
0.036672379821538925,
-0.025013748556375504,
0.00995673332363367,
0.023660147562623024,
-0.021646348759531975,
0.01762034371495247,
-0.013926513493061066,
-0.05210578441619873,
0.00986834242939949,
-0.006386552006006241,
-0.01019639428704977,
0.03144611045718193,
-0.01186005212366581,
-0.00032774085411801934,
0.02988167107105255,
-0.012599579058587551,
-0.0010879265610128641,
0.04693964123725891,
0.015527217648923397,
0.009081894531846046,
-0.0038740052841603756,
-0.008570533245801926,
0.0035058320499956608,
0.003829266643151641,
-0.002608157927170396,
-0.01132059283554554,
-0.01489799190312624,
-0.00788144115358591,
0.011248962953686714,
0.01934804581105709,
0.007992463186383247,
-0.007466528564691544,
-0.009986259043216705,
-0.0016120667569339275,
0.001830931520089507,
0.004447494633495808,
0.008307717740535736,
-0.005045159719884396,
0.021008295938372612,
-0.0019270272459834814,
-0.04814261943101883,
-0.016997504979372025,
-0.011298710480332375,
-0.010638580657541752,
-0.01162264309823513,
-0.019555503502488136,
-0.003008189145475626,
0.008698436431586742,
-0.024968625977635384,
0.012736055999994278,
-0.024000365287065506,
-0.015714790672063828,
-0.011307024396955967,
0.007983142510056496,
0.03022649884223938,
0.031091060489416122,
0.026681620627641678,
0.00025320181157439947,
-0.0071623120456933975,
-0.0289416816085577,
-0.004607673734426498,
0.014173680916428566,
-0.003512786701321602,
0.010956766083836555,
0.0006517970468848944,
-0.03264697268605232,
0.006959710270166397,
-0.010609348304569721,
0.014319680631160736,
0.009600824676454067,
0.019063135609030724,
0.012486743740737438,
-0.0017616958357393742,
-0.020153455436229706,
0.002468868624418974,
0.029339294880628586,
-0.007283496670424938,
-0.025755025446414948,
0.028378183022141457,
-0.022152800112962723,
-0.005069819279015064,
-0.0038668024353682995,
-0.014928612858057022,
0.0021205791272222996,
0.014289367944002151,
0.010724433697760105,
0.005057711619883776,
0.01581477001309395,
-0.006590157747268677,
-0.0293322391808033,
0.0012303690891712904,
-0.020115792751312256,
-0.014381492510437965,
0.019302837550640106,
0.023917915299534798,
-0.022480271756649017,
0.005966365337371826,
-0.00013631745241582394,
-0.0006790289771743119,
-0.02187126688659191,
-0.005292756482958794,
-0.0068644327111542225,
-0.0058618881739676,
-0.009781856089830399,
0.010495239868760109,
0.013791767880320549,
-0.027988608926534653
] | [
0.18912020325660706,
0.04876964911818504,
-0.19642138481140137,
-0.02564471960067749,
0.059782255440950394,
0.36333703994750977,
0.0857052356004715,
-0.13348405063152313,
-0.47007784247398376,
-0.17915523052215576,
0.6169607639312744,
0.14417991042137146,
0.1541578620672226,
0.0667322427034378,
-0.2891668975353241,
0.13840463757514954,
0.7505332827568054,
0.27038800716400146,
-0.0044268774800002575,
-0.37454211711883545,
-0.46723246574401855,
-0.7713509798049927,
0.4293539822101593,
0.4186241030693054,
-0.11090847849845886,
0.26358190178871155,
0.6377125978469849,
0.05943412333726883,
0.34190499782562256,
-0.00045913629583083093,
-0.0817379578948021,
0.2723589837551117,
0.5918095111846924,
-0.4989207088947296,
0.18571257591247559,
0.12333459407091141,
0.03226650506258011,
0.19046978652477264,
-0.1749110072851181,
-0.3175916075706482,
-0.3637987971305847,
-0.05742085725069046,
-0.279080867767334,
0.23938047885894775,
0.35479000210762024,
-0.35654547810554504,
-1.1890442371368408,
0.3738299310207367,
-0.1790647953748703,
0.2572258412837982,
-0.027357660233974457,
0.056282706558704376,
0.05921557918190956,
0.32241901755332947,
-0.11594268679618835,
0.3039359152317047,
-0.31518593430519104,
-0.03708123043179512,
0.015737194567918777,
-0.4333897829055786,
-0.025940755382180214,
-0.29277855157852173,
0.3754837214946747,
0.284344881772995,
-0.08340819925069809,
0.46467673778533936,
0.12984055280685425,
0.24057839810848236,
0.20897176861763,
-0.5979953408241272,
-0.30354148149490356,
-0.6380061507225037,
-0.14119166135787964,
0.16153210401535034,
0.16969138383865356,
0.38464948534965515,
0.006336285267025232,
-0.4135914146900177,
0.21936628222465515,
0.12419398874044418,
-0.2111261785030365,
0.19636495411396027,
0.19917237758636475,
-0.27807849645614624,
0.7143499851226807,
-0.13919690251350403,
-0.10652923583984375,
0.3985903263092041,
0.5670751929283142,
-0.008345618844032288,
-0.4848685562610626,
0.19787177443504333,
0.5371435284614563,
0.2138965129852295,
0.10197323560714722,
0.20140919089317322,
-0.19141758978366852,
0.3939945697784424,
0.20623160898685455,
-0.1433762013912201,
-0.2198914736509323,
0.17077304422855377,
0.17371398210525513,
0.29106277227401733,
-0.7987257838249207,
-0.35837501287460327,
0.05006064102053642,
-0.3004375398159027,
-0.33096134662628174,
-0.004372496157884598,
-0.16515912115573883,
0.3879549503326416,
0.010642125271260738,
-0.1192602887749672,
-0.2979692816734314,
0.5413904190063477,
0.39525437355041504,
-0.6935561895370483,
-0.1439463198184967,
-0.2686409056186676,
-0.9066239595413208,
0.8511587977409363,
-0.22439414262771606,
0.4214739501476288,
-0.0057655940763652325,
0.30249878764152527,
0.7532014846801758,
0.4944072365760803,
-0.5258904695510864,
0.22420044243335724,
-0.26396265625953674,
0.6068457961082458,
0.3511628806591034,
0.06877432763576508,
0.13330143690109253,
-0.30351513624191284,
-0.20055937767028809,
0.31911778450012207,
0.24680840969085693,
-0.004572773817926645,
-0.40228188037872314,
-0.47408992052078247,
-0.18019340932369232,
-0.2584817409515381,
0.08203981071710587,
-0.4675086438655853,
0.0998363345861435,
-0.11926812678575516,
-0.4113747775554657,
-0.24410806596279144,
0.1724195033311844,
-0.24335962533950806,
-0.01750730536878109,
-0.38140231370925903,
0.23713073134422302,
0.6628422141075134,
-0.15870140492916107,
0.08035360276699066,
0.4339407682418823,
-0.16799500584602356,
0.12683752179145813,
0.6163995862007141,
-0.4658280909061432,
0.10658067464828491,
0.3000691533088684,
0.05143966153264046,
-0.18840180337429047,
-0.32180485129356384,
0.7403715252876282,
0.2863958179950714,
-0.5323367714881897,
-0.21373297274112701,
-0.2576688528060913,
-0.15764689445495605,
-0.1088167130947113,
-0.1687309890985489,
0.3710089325904846,
0.10336517542600632,
-0.46386972069740295,
0.08058901131153107,
-0.5177672505378723,
0.22976800799369812,
-0.18981947004795074,
-0.6585174202919006,
-0.09963809698820114,
-0.12719182670116425,
0.3665606379508972,
0.0714430958032608,
-0.35414284467697144,
0.46411779522895813,
-0.23738370835781097,
-0.3603600263595581,
0.7755296230316162,
-0.16788114607334137,
1.3100694417953491,
0.005383085925132036,
-0.2473495602607727,
1.2896718978881836,
-0.11625047028064728,
-0.09062516689300537,
-0.2068609744310379,
0.17734205722808838,
0.5687110424041748,
-0.04082490876317024,
-1.2706652879714966,
-0.38644447922706604,
0.06979779154062271,
-0.2649186849594116,
-0.17781633138656616,
0.42168471217155457,
-0.00012047350901411846,
0.018972113728523254,
-0.5062159895896912,
0.05360976606607437,
0.05573778599500656,
0.21634024381637573,
-0.04681915417313576,
0.18456138670444489,
0.5013155937194824,
-0.4994567930698395,
0.24409592151641846,
-0.5657213926315308,
0.5611870288848877,
0.37259441614151,
0.32206252217292786,
0.6497395634651184,
0.2753416895866394,
0.20679494738578796,
0.457671582698822,
-0.2351638674736023,
0.3732578754425049,
0.26901575922966003,
0.33053380250930786,
-0.48432233929634094,
0.042326558381319046,
0.23107272386550903,
-0.07125554978847504,
-0.6160257458686829,
-0.3348384499549866,
0.2599110007286072,
0.4968855082988739,
0.19917024672031403,
-0.4929160475730896,
0.1269567310810089,
0.16314682364463806,
-0.255632609128952,
-0.1805039942264557,
0.2463456094264984,
0.09885403513908386,
0.1928449273109436,
-0.007076909765601158,
0.4796709716320038,
-0.00959504023194313,
-0.46260586380958557,
0.011138835921883583,
0.07607501745223999,
-0.024572528898715973,
-0.8432784676551819,
0.5857701897621155,
-0.4975743591785431,
0.14059580862522125,
0.3155304789543152,
0.14393022656440735,
0.4153312146663666,
0.37733325362205505,
-0.5880659818649292,
-0.5671136379241943,
-0.512362003326416,
0.41691768169403076,
0.7461681365966797,
0.5856487154960632,
-0.04970470443367958,
-0.8241094946861267,
-0.09467842429876328,
-0.178363636136055,
-0.8288615942001343,
-0.5067725777626038,
0.6958036422729492,
-0.24718783795833588,
-0.7171118259429932,
0.010450884699821472,
0.3935393989086151,
0.672407865524292,
-0.4328364133834839,
-0.024210471659898758,
-0.020194629207253456,
-0.18632450699806213,
-0.14051349461078644,
-0.4432373046875,
-0.4451236128807068,
0.004150756169110537,
0.21844418346881866,
-0.2791652977466583,
0.25233563780784607,
0.384147971868515,
0.1911431849002838,
-0.35290291905403137,
0.43511104583740234,
0.7905202507972717,
0.07864229381084442,
-0.2762846052646637,
-0.12072984129190445,
-0.5766502618789673,
-0.19633539021015167,
-0.1080658808350563,
0.03182319924235344,
0.03530946746468544,
-0.5123772025108337,
-6.022112846374512,
0.020718347281217575,
-0.2834537923336029,
-0.4182894825935364,
-0.2827650010585785,
0.4631270170211792,
0.8235498070716858,
-0.5304480791091919,
0.36967188119888306,
0.30400121212005615,
0.30464449524879456,
0.4748779833316803,
0.022391295060515404,
0.11225132644176483,
0.1813245713710785,
0.23013752698898315,
0.271027535200119,
-0.4063165783882141,
0.5416073799133301,
-0.428549200296402,
0.6441988945007324,
-0.3347803056240082,
-0.08350154757499695,
0.3045732080936432,
0.31745246052742004,
0.5959019660949707,
-0.6412255167961121,
0.3689790964126587,
-0.23219019174575806,
0.06114453077316284,
0.19751641154289246,
-0.2619606852531433,
-0.17276939749717712,
0.326984703540802,
-0.39485281705856323,
0.35702329874038696,
0.2829645872116089,
-0.18262577056884766,
0.07446493208408356,
-0.12426992505788803,
-0.0710562989115715,
0.008441071957349777,
-0.2689577341079712,
-0.2101742923259735,
0.11721397936344147,
0.35735487937927246,
0.203785240650177,
-0.2739103138446808,
-0.16847509145736694,
0.7202766537666321,
0.4604620337486267,
-0.0409993939101696,
0.41987407207489014,
0.761862576007843,
-0.35064610838890076,
-0.03281021490693092,
-0.4499525725841522,
0.08682321757078171,
-0.8108034133911133,
0.03187704086303711,
-0.1503930687904358,
-0.1580687314271927,
0.34473857283592224,
-1.1201075315475464,
0.08983784914016724,
-0.05825559422373772,
-0.519025444984436,
-0.18690481781959534,
-0.06620284914970398,
0.13282833993434906,
0.004768312443047762,
0.41480502486228943,
-0.15648075938224792,
-0.969586968421936,
0.3185916543006897,
-0.6604251861572266,
-0.07868698239326477,
0.18909241259098053,
-0.2682642340660095,
-0.44457969069480896,
0.05000986531376839,
0.20795892179012299,
0.2045697569847107,
0.16890332102775574,
0.13567793369293213,
-0.07650116831064224,
0.11684246361255646,
0.0361924022436142,
-0.18306812644004822,
0.07491295784711838,
0.5484188199043274,
-0.061332084238529205,
0.18014302849769592,
0.5344367027282715,
0.10532207787036896,
0.7271323204040527,
0.39143964648246765,
-0.2247903048992157,
0.4267396330833435,
-0.28794968128204346,
0.21530188620090485,
0.12150011211633682,
-0.9296683669090271,
-0.9669894576072693,
-0.6084414124488831,
-0.3539525270462036,
-0.5105772018432617,
-0.2236301749944687,
0.53058260679245,
-0.8373551368713379,
0.02930947206914425,
-0.22818991541862488,
-0.16852618753910065,
-0.40109381079673767,
0.4810042381286621,
-0.13186238706111908,
-0.11712327599525452,
0.25358179211616516,
0.827946126461029,
-0.18392714858055115,
0.5633443593978882,
0.07935774326324463,
-0.23024599254131317,
0.36600369215011597,
0.4646209180355072,
-0.45520666241645813,
0.03433264046907425,
0.5296717286109924,
-0.8677703738212585,
0.688432514667511,
0.14979144930839539,
0.27429652214050293,
-0.24618840217590332,
-0.14136230945587158,
0.035724252462387085,
-0.014036866836249828,
-0.7237527966499329,
-0.09485859423875809,
0.08807254582643509,
0.5946279764175415,
-0.3162515163421631,
0.4534579813480377,
-0.3481343984603882,
0.37958791851997375,
0.07013989984989166,
0.06766550987958908,
-0.07040923833847046,
-0.31866154074668884,
-0.612008810043335,
-0.2073783427476883,
-0.33842551708221436,
-0.4078039228916168,
0.27441051602363586,
0.19040963053703308,
-0.19816049933433533,
-0.021967047825455666,
0.7176612019538879,
0.47374773025512695,
-0.24457359313964844,
-0.09808884561061859,
0.1642788052558899,
0.007292646914720535,
-1.1416594982147217,
0.04516203701496124,
-0.22236387431621552,
-0.2380857765674591,
-0.24034206569194794,
-0.23145297169685364,
-0.30866187810897827,
0.36285504698753357,
0.2068846970796585,
-0.6061633825302124,
-0.07529986649751663,
0.5136261582374573,
0.47177281975746155,
0.06143186241388321,
0.17275124788284302,
-0.04860760271549225,
-0.12543708086013794,
0.13244034349918365,
-0.07387401908636093,
-0.6223529577255249,
-0.5141996145248413,
0.19834719598293304,
0.7963768243789673,
0.5653564929962158,
-0.8958438634872437,
-0.5095784664154053,
-0.5495471954345703,
0.19736553728580475,
0.2052137851715088,
-0.38322749733924866,
0.3890073299407959,
0.21687014400959015,
-0.5164220929145813,
-0.10629863291978836,
0.1294960081577301,
0.012149682268500328,
-0.22503912448883057,
-0.2507735788822174,
0.024202682077884674,
0.2521935701370239,
-0.232381209731102,
0.34184029698371887,
0.007726381998509169,
-0.2670396864414215,
-0.23487059772014618,
-0.03413848951458931,
-0.6897619962692261,
0.11457855254411697,
0.04122116044163704,
0.026925958693027496,
0.2139001041650772,
0.6168205738067627,
-0.08074428886175156,
0.3391772508621216,
0.00771949952468276,
0.020014870911836624,
0.0410902202129364,
0.08542606234550476,
0.08131315559148788,
0.13396866619586945,
-0.6120490431785583,
-0.4391837418079376,
-0.7865472435951233,
0.5329263806343079,
0.20822125673294067,
-1.0990020036697388,
-0.05589127913117409,
0.058456238359212875,
-0.14078271389007568,
-0.24779364466667175,
-0.15257467329502106,
-0.17674247920513153,
-0.05150579661130905,
-0.1210547462105751,
-0.12406761199235916,
0.05653105303645134,
0.0076175956055521965,
0.579171359539032,
-0.020488973706960678,
0.5217321515083313,
-0.14994676411151886,
-0.18742378056049347,
-0.16575509309768677,
0.0935622826218605,
0.26862436532974243,
-0.3889181315898895,
-0.33717191219329834,
0.6854645013809204,
0.2648455798625946,
-0.3398139178752899,
0.13088256120681763,
-0.48217639327049255,
0.579498291015625,
0.43320998549461365,
-0.5630903840065002,
-0.2763631343841553,
-0.12327633053064346,
-0.1440155804157257,
-0.1552714854478836,
-0.25295761227607727,
-0.7755258679389954,
0.0001567411090945825,
0.3398878276348114,
0.279956579208374,
0.02770828641951084,
-0.19788193702697754,
-0.031040439382195473,
-0.4812365472316742,
0.06449566781520844,
0.09871841967105865,
0.47464266419410706,
0.4569046199321747,
0.1653420776128769,
0.09786006808280945,
-0.14646561443805695,
0.20420806109905243,
0.3412342667579651,
0.20328748226165771,
-0.1954718977212906,
-0.5744980573654175,
0.2139308750629425,
0.15745435655117035,
0.34851545095443726,
-0.3540233373641968,
-0.08467492461204529,
0.12143905460834503,
-0.37218597531318665,
-0.03453874588012695,
0.11755325645208359,
-0.004019772168248892,
-0.6450048089027405,
-0.38024652004241943,
-0.018074585124850273,
0.37245678901672363,
0.36949384212493896,
0.44343286752700806,
-0.3551221787929535,
-0.28082093596458435,
-0.6030822396278381,
0.3562769889831543,
0.4900195300579071,
-0.3263154923915863,
-0.2025909125804901,
0.15528438985347748,
0.22837214171886444,
0.08053334057331085,
-0.46710193157196045,
0.17472721636295319,
0.10658765584230423,
-0.11970620602369308,
0.4814586639404297,
0.5115945935249329,
-1.0923057794570923,
0.13511274755001068,
-0.0692337155342102,
-0.07048825174570084,
0.21015268564224243,
-0.3003474771976471,
-0.17417524755001068,
0.8889609575271606,
0.5420209169387817,
-0.10156518220901489,
-0.14181701838970184,
0.3177887201309204,
-0.11690875142812729,
0.3358890116214752,
0.2898479402065277,
0.21807752549648285,
0.2601170837879181,
0.2036498636007309,
-0.07662269473075867,
0.463204026222229,
-0.2105671614408493,
0.23247450590133667,
-0.20651687681674957,
-0.6259650588035583,
-0.45041942596435547,
0.4360356628894806,
0.8364353775978088,
0.5144590735435486,
0.01582590490579605,
-0.06594185531139374,
0.059395186603069305,
0.37231501936912537,
0.13405361771583557,
-0.02897251583635807,
0.7571191787719727,
0.1947695016860962,
-0.03771870583295822,
-0.14656776189804077,
-0.3156796395778656,
0.46554964780807495,
-0.3423277735710144,
-0.09601709991693497,
0.27179282903671265,
0.14704936742782593,
-0.0661798045039177,
0.12300461530685425,
-0.253669410943985,
-0.13465097546577454,
-0.35671454668045044,
0.2565855383872986,
-0.04763589799404144,
-0.0325462706387043,
0.4770123362541199,
0.20634299516677856,
-0.10397706180810928,
0.09836628288030624,
0.29578742384910583,
0.3102918267250061,
-0.3443703055381775,
-0.027683325111865997,
0.11504217237234116,
-0.4504219889640808,
0.07327741384506226,
-0.15146379172801971,
-0.1665475219488144,
0.4887058734893799,
-0.17487642168998718,
-0.05886586382985115,
-0.21423089504241943,
-0.3742755353450775,
-0.08245031535625458,
0.055170413106679916,
-0.11899296939373016,
0.41521912813186646,
0.21141691505908966,
-0.30426540970802307,
0.010264488868415356,
-0.5842571258544922,
-0.11646290868520737,
0.5517004728317261,
-0.15416337549686432,
0.4606803357601166,
-0.16289788484573364,
-0.1732204258441925,
0.5431281924247742,
0.21543926000595093,
-0.37370428442955017,
-0.1940939724445343,
-0.05041765049099922,
0.4926999807357788,
-0.42436838150024414,
0.5349836349487305,
-0.5172591805458069,
-0.37372228503227234,
-0.6608584523200989,
0.12440193444490433,
0.2440270632505417,
0.8195133209228516,
-0.10421348363161087,
0.17788413166999817,
-0.1941239982843399,
0.09162561595439911,
0.5667784810066223,
-0.37617647647857666,
-0.45182690024375916,
-0.08059932291507721,
-0.8725690841674805,
-0.8207738399505615,
0.10295622795820236,
0.16451044380664825,
0.16332568228244781,
-0.3025030791759491,
0.4160490930080414,
-0.1379692703485489,
-0.08329150825738907,
0.3007940649986267,
-0.026508305221796036,
-0.08434145152568817,
-0.26211774349212646,
0.022664660587906837,
-0.37833499908447266,
0.21511462330818176,
0.02075100503861904,
0.45396167039871216,
0.94122314453125,
-0.2255520224571228,
0.37945306301116943,
-0.7636289596557617,
-0.14917698502540588,
0.018133895471692085,
0.38673463463783264,
0.33621451258659363,
0.04218015447258949,
-0.6479553580284119,
-0.4490475058555603,
0.2768521308898926,
-0.3752111494541168,
0.01085445936769247,
-0.25642672181129456,
-0.2750852406024933,
-0.06455483287572861,
-0.037548355758190155,
-0.12840530276298523,
-0.2498665302991867,
-0.07002943009138107,
-0.06153002753853798
] |
Preconception care (PCC) and strict periconceptional glycemic control are both used to minimize the risk of congenital birth defects in offspring of women with type 1 or type 2 diabetes mellitus (DM). These malformations are ascribed in large measure to poor periconceptional control. This study evaluated PCC by a meta-analysis of published studies of PCC in women with DM, published from 1970 to 2000. Two reviewers independently abstracted the data, and the rate and relative risk (RR) of major and minor malformations were pooled from eligible studies using a random effects model. Early first-trimester values of glycosylated hemoglobin were recorded. Eight retrospective and eight prospective cohort studies were included; they were carried out in Europe, the United Kingdom, the United States, and Israel. Most participants had type 1 DM, but three studies included women with type 2 DM. Women given PCC tended to be about 2 years older on average than the others. Methods of PCC were quite variable, although most centers provided some maternal education about the pregnancy risks associated with poor glycemic control. In seven studies reporting early gestational glycosylated hemoglobin values, mean levels were consistently lower in PCC patients. Among 2104 offspring, the pooled rate for major and minor anomalies was 2.4% in the PCC group and 7.7% in non-PCC recipients, for a pooled RR of 0.32. Among 2651 offspring, major malformations were less prevalent in the PCC group (2.1 vs. 6.5%; pooled RR = 0.36). Comparable results were obtained when only prospective studies were analyzed and in studies where the infant examiners were unaware of the mothers' PCC status. The lowest risk of major anomalies was in a study that administered folic acid periconceptionally to its PCC recipients; the RR was 0.11. This meta-analysis, which included both retrospective and prospective studies, demonstrates an association of PCC with a significantly lower risk of congenital anomalies in the offspring of women with established DM. The lowered risk was accompanied by significantly lower glycosylated hemoglobin values in the first trimester in recipients of PCC. | [
-0.01056439895182848,
0.010660583153367043,
-0.02503792755305767,
0.014157578349113464,
0.007468800991773605,
-0.009564001113176346,
0.009731772355735302,
-0.02441629208624363,
-0.009714508429169655,
-0.017122842371463776,
-0.0033619175665080547,
0.004538858775049448,
0.0012421554420143366,
0.008045426569879055,
-0.006013745442032814,
-0.0064147296361625195,
-0.019445940852165222,
0.04767638444900513,
0.011851191520690918,
0.010987496934831142,
0.00015788991004228592,
0.002282985020428896,
0.009844963438808918,
0.04482679069042206,
0.006715486291795969,
0.010092221200466156,
-0.0021336255595088005,
-0.013765094801783562,
-0.0019268086180090904,
-0.016602693125605583,
-0.0037546702660620213,
-0.00959060713648796,
0.003471534699201584,
0.02286207489669323,
-0.005626070778816938,
0.008216512389481068,
0.005041984841227531,
0.016161158680915833,
-0.013719598762691021,
-0.00450095534324646,
-0.011997676454484463,
-0.014349935576319695,
0.011460413224995136,
0.01796206831932068,
-0.004732121713459492,
-0.014350662007927895,
-0.0010392171097919345,
0.013042766600847244,
0.017593082040548325,
0.009231965988874435,
-0.01082676649093628,
-0.011176252737641335,
-0.013659702613949776,
0.007675280794501305,
-0.005727776791900396,
-0.02659902349114418,
0.01744496263563633,
-0.009254859760403633,
0.0011719907633960247,
0.003265917068347335,
-0.010789351537823677,
-0.025741655379533768,
0.017894092947244644,
-0.020823467522859573,
-0.014006357640028,
-0.06704029440879822,
0.015187621116638184,
0.005657184403389692,
-0.006549220532178879,
0.0008677667938172817,
0.020427878946065903,
0.007195783779025078,
-0.017043758183717728,
-0.007744374219328165,
0.002074357122182846,
-0.02512522041797638,
0.005647299345582724,
0.027056684717535973,
-0.006333222147077322,
0.0033946046605706215,
-0.037395235151052475,
-0.0266411192715168,
-0.023530133068561554,
0.02063858136534691,
0.013512199744582176,
-0.02317143604159355,
-0.0015310572925955057,
0.017448024824261665,
-0.0030579627491533756,
0.01709957793354988,
0.012170585803687572,
-0.010652707889676094,
-0.021985918283462524,
-0.01680692657828331,
-0.03665651008486748,
-0.018077457323670387,
-0.01252216286957264,
0.005574320442974567,
-0.018825527280569077,
-0.027389127761125565,
-0.02312324568629265,
0.0005350806750357151,
0.013178824447095394,
-0.020659249275922775,
-0.0016134580364450812,
0.013885055668652058,
-0.010605951771140099,
0.001617441768757999,
-0.013620419427752495,
0.00942683219909668,
-0.0044708396308124065,
0.019705161452293396,
0.005849770270287991,
-0.024193279445171356,
0.017198417335748672,
0.022128600627183914,
0.018291201442480087,
-0.012974298559129238,
0.007501062471419573,
-0.015312915667891502,
0.00619406346231699,
0.006281957030296326,
0.0033302439842373133,
0.03444129601120949,
-0.0006408002227544785,
0.00819152407348156,
0.02731325477361679,
0.012026311829686165,
0.00007632141932845116,
-0.004669873975217342,
-0.007076807785779238,
-0.014522869139909744,
-0.021602433174848557,
-0.012564814649522305,
0.001660699024796486,
-0.00005477716331370175,
-0.0035935351625084877,
-0.02293635532259941,
-0.006154317408800125,
-0.01376248337328434,
-0.011772384867072105,
0.007797350641340017,
-0.0006094702985137701,
0.003949551843106747,
0.007013754453510046,
0.009271258488297462,
-0.03584415838122368,
0.00784214772284031,
0.020207203924655914,
-0.013336632400751114,
-0.027147429063916206,
-0.00566986296325922,
-0.016539812088012695,
-0.00815134309232235,
-0.002538160188123584,
-0.014652730897068977,
-0.012992103584110737,
-0.011604996398091316,
0.014462740160524845,
0.01036034431308508,
-0.010076658800244331,
0.005315027665346861,
0.017621349543333054,
0.007709129247814417,
0.017238447442650795,
0.023523032665252686,
-0.007955011911690235,
0.013269023038446903,
-0.025694169104099274,
0.0049010333605110645,
-0.0156618170440197,
-0.005749186035245657,
-0.00038293376564979553,
0.008787039667367935,
0.0024205250665545464,
0.00035140581894665956,
0.015263850800693035,
0.008131295442581177,
0.002485585631802678,
0.06655380129814148,
0.0030658873729407787,
0.003606541780754924,
-0.019347339868545532,
-0.014083967544138432,
0.006405611056834459,
-0.01332533173263073,
-0.00515266228467226,
-0.004107361193746328,
-0.00460420548915863,
-0.0022455279249697924,
-0.0018031420186161995,
0.007807325571775436,
-0.00897139124572277,
0.02060103230178356,
-0.020885493606328964,
0.00406733388081193,
-0.025316717103123665,
0.016563110053539276,
0.021017983555793762,
0.011270388029515743,
-0.015455134212970734,
-0.004950900562107563,
0.015211333520710468,
0.005869643297046423,
0.008236810564994812,
0.00860472023487091,
-0.027389314025640488,
-0.011357343755662441,
0.01757833920419216,
-0.011884253472089767,
0.010648565366864204,
-0.030720094218850136,
0.023620102554559708,
-0.000761235598474741,
0.008484763093292713,
-0.003648392390459776,
-0.014072919264435768,
-0.023640140891075134,
-0.002247542142868042,
-0.015401527285575867,
0.0024633053690195084,
0.01694120094180107,
0.0020857134368270636,
-0.0032718395814299583,
0.002741122618317604,
-0.032787077128887177,
0.006224381737411022,
0.007541992701590061,
0.002408379688858986,
0.0021464130841195583,
-0.009961524978280067,
-0.016517452895641327,
-0.008635188452899456,
0.009490594267845154,
-0.0022252474445849657,
-0.0016336822882294655,
0.013525005429983139,
0.01311509683728218,
0.00437489990144968,
-0.017026498913764954,
-0.027453098446130753,
0.006474309600889683,
0.021512873470783234,
-0.005282003432512283,
0.03300885856151581,
-0.0016751663060858846,
0.00768112950026989,
0.01640741527080536,
-0.01407020166516304,
-0.00027463980950415134,
0.005302900448441505,
-0.025789285078644753,
0.03335261717438698,
-0.00023683183826506138,
0.033994730561971664,
0.006490728352218866,
0.003614984918385744,
0.009681511670351028,
0.024362150579690933,
-0.020101604983210564,
0.0071115754544734955,
0.0027360348030924797,
0.0010583894327282906,
-0.013240167871117592,
-0.0008315067971125245,
0.02081235498189926,
0.02387409098446369,
0.018258579075336456,
0.023479966446757317,
0.040572620928287506,
0.007470621727406979,
-0.00831393152475357,
-0.01051235944032669,
-0.08171305060386658,
-0.015917973592877388,
0.017326513305306435,
0.003431744407862425,
0.0027392678894102573,
0.014227058738470078,
0.013260558247566223,
-0.012474545277655125,
-0.001979971071705222,
-0.02600196748971939,
0.00465022400021553,
-0.010069077834486961,
-0.001968295779079199,
0.04398685693740845,
-0.008523330092430115,
-0.008276037871837616,
0.004297356121242046,
-0.00530916778370738,
-0.027569733560085297,
-0.006897834129631519,
0.00023583404254168272,
0.024890735745429993,
0.0029466995038092136,
0.002084719715639949,
0.0005696653388440609,
0.010433152318000793,
0.006587870419025421,
0.00535315927118063,
-0.02054549753665924,
-0.0008246945217251778,
0.011552337557077408,
-0.017960358411073685,
0.030434414744377136,
0.0051965778693556786,
-0.030291039496660233,
-0.03305170312523842,
-0.005620626732707024,
-0.020778920501470566,
-0.010593941435217857,
0.019507039338350296,
-0.016505200415849686,
0.014370834454894066,
-0.0008368920534849167,
-0.011258222162723541,
0.008255946449935436,
-0.004354587756097317,
0.0251933541148901,
0.0445554256439209,
0.02409108355641365,
0.020039793103933334,
0.001348906196653843,
-0.003914549481123686,
0.03233828395605087,
0.01206681877374649,
-0.014741577208042145,
-0.0189351923763752,
0.004837024956941605,
-0.00011156592518091202,
-0.01221221312880516,
-0.018999364227056503,
0.016872165724635124,
-0.007793657016009092,
0.002886126982048154,
-0.0029875035397708416,
-0.008943679742515087,
-0.006003682501614094,
0.01941496878862381,
-0.0198728758841753,
-0.009981303475797176,
0.0022263084538280964,
0.010942431166768074,
-0.025264820083975792,
-0.013884510844945908,
-0.01639873906970024,
0.0025625438429415226,
-0.0045846737921237946,
-0.011131111532449722,
-0.011631377972662449,
0.013461447320878506,
0.0011333427391946316,
0.0032198242843151093,
-0.00730934040620923,
-0.0018509295769035816,
0.0011446368880569935,
-0.009692720137536526,
0.0157649964094162,
0.006813693791627884,
0.0113937733694911,
0.017022375017404556,
-0.01823100820183754,
-0.019053420051932335,
0.021516799926757812,
-0.032516948878765106,
0.012907775118947029,
0.009257671423256397,
0.007831637747585773,
0.015986386686563492,
0.003605432342737913,
0.009405122138559818,
0.009648224338889122,
-0.014040518552064896,
0.012034458108246326,
-0.022670764476060867,
-0.012412155978381634,
-0.015056018717586994,
0.015710147097706795,
0.0037126420065760612,
0.008960215374827385,
-0.010821763426065445,
-0.007937307469546795,
-0.030159521847963333,
0.003647646401077509,
-0.003874704008921981,
0.03703700751066208,
0.011739891953766346,
0.03408776968717575,
0.025031190365552902,
0.0011357013136148453,
0.0727853924036026,
-0.00072745222132653,
0.004348318558186293,
-0.004254770930856466,
-0.002395416609942913,
-0.02877977304160595,
-0.01324040349572897,
-0.005017394199967384,
0.02933630533516407,
0.007088938262313604,
0.012151233851909637,
-0.010828899219632149,
0.002825029892846942,
-0.007895375601947308,
-0.006334752310067415,
-0.0015792847843840718,
-0.013279886916279793,
-0.01516133826225996,
0.008092647418379784,
-0.010328631848096848,
-0.019947398453950882,
-0.013944738544523716,
0.000326413894072175,
0.009951054118573666,
-0.0004789765225723386,
-0.009116796776652336,
-0.012898925691843033,
-0.01160851027816534,
-0.03165493160486221,
0.0038735840935260057,
-0.026799295097589493,
0.02014469914138317,
-0.004595819860696793,
0.0015247883275151253,
0.01452409103512764,
-0.007432570680975914,
0.01871713623404503,
0.0030807398725301027,
0.009443288668990135,
0.0007304016035050154,
0.02900036983191967,
-0.01769240014255047,
-0.0014238657895475626,
0.005701808258891106,
0.00936412625014782,
-0.012244893237948418,
0.014047225937247276,
-0.007307709194719791,
0.010747987776994705,
-0.011801284737884998,
-0.018690312281250954,
-0.004574448801577091,
0.011671188287436962,
0.025967475026845932,
-0.0008553750230930746,
0.014672319404780865,
-0.012861627154052258,
-0.007748612202703953,
-0.0281235221773386,
0.002643077401444316,
-0.0030330850277096033,
-0.011492496356368065,
0.01904035359621048,
-0.004547285381704569,
0.0064979176968336105,
-0.00002345489338040352,
0.0010089576244354248,
-0.012505859136581421,
-0.027989260852336884,
-0.009364940226078033,
-0.029440581798553467,
0.0014934223145246506,
-0.0037242937833070755,
0.006318787112832069,
-0.020937083289027214,
-0.0030359188094735146,
-0.014235040172934532,
-0.00913749635219574,
-0.030019480735063553,
-0.008558982983231544,
-0.008099065162241459,
-0.010055124759674072,
-0.020213458687067032,
-0.01461495365947485,
0.013176573440432549,
0.01902250200510025,
0.0185344647616148,
-0.07513265311717987,
-0.002396463416516781,
-0.014229021966457367,
-0.007742241956293583,
0.0005577781703323126,
0.008372660726308823,
-0.007375301793217659,
0.00003642123192548752,
-0.021863561123609543,
0.007396658416837454,
-0.006774858571588993,
-0.0284408126026392,
-0.0284922756254673,
-0.01570741832256317,
0.014291114173829556,
-0.0035399179905653,
-0.012438345700502396,
0.010375947691500187,
0.013563721440732479,
0.017812738195061684,
0.017521223053336143,
-0.0029002134688198566,
-0.03873554617166519,
-0.02288638986647129,
0.0027029667980968952,
-0.08155211806297302,
0.003036981914192438,
0.023669468238949776,
0.008704137057065964,
0.006474094465374947,
-0.0020718614105135202,
-0.004073453601449728,
-0.00301729841157794,
0.008756115101277828,
-0.0167759470641613,
-0.013528742827475071,
0.02018076740205288,
-0.0019618861842900515,
-0.006900419481098652,
-0.011425424367189407,
-0.008269109763205051,
0.016977738589048386,
0.019162310287356377,
-0.009899718686938286,
0.011934040114283562,
0.0016399906016886234,
-0.02080666273832321,
-0.01120075024664402,
-0.022394752129912376,
-0.008461344055831432,
0.0037540518678724766,
-0.031819626688957214,
0.01340390183031559,
0.015974219888448715,
-0.017689907923340797,
-0.0014294655993580818,
-0.002902147825807333,
-0.0017045959830284119,
-0.01309264823794365,
-0.0029291717801243067,
-0.00452906871214509,
0.010461143217980862,
-0.011897333897650242,
0.02053093910217285,
-0.013012612238526344,
0.0028669708408415318,
0.014492616057395935,
-0.03766319155693054,
0.011090816929936409,
0.008736487478017807,
0.028498195111751556,
0.004155856557190418,
-0.013626158237457275,
-0.0022979499772191048,
-0.014782190322875977,
0.00937647558748722,
-0.012798143550753593,
0.02364840731024742,
-0.017992794513702393,
0.0076819551177322865,
0.003869034117087722,
-0.012781850062310696,
0.0052761901170015335,
0.003959950525313616,
0.0024039309937506914,
0.01597832702100277,
0.013557463884353638,
-0.021122869104146957,
0.07162491977214813,
-0.01779942587018013,
0.013917682692408562,
-0.01255416963249445,
-0.010057944804430008,
0.003052734537050128,
0.001768409158103168,
-0.011140486225485802,
0.0006939000450074673,
-0.01377943716943264,
-0.0031511476263403893,
-0.009849892929196358,
0.0028183700051158667,
0.01613539457321167,
-0.004792476072907448,
-0.0031079144682735205,
0.024490773677825928,
-0.011543700471520424,
-0.01097167283296585,
0.00811539776623249,
-0.018188925459980965,
0.0086173415184021,
0.005513355601578951,
0.005244527943432331,
0.00430075079202652,
0.0008625587215647101,
0.020269153639674187,
0.02863883599638939,
-0.018010443076491356,
-0.003398152766749263,
-0.0009583835490047932,
0.019544418901205063,
0.007133036386221647,
0.019199088215827942,
0.00823898147791624,
0.01308850385248661,
-0.004603262525051832,
0.002378186909481883,
0.0068554962053895,
0.004730768036097288,
0.006326435133814812,
0.004494129680097103,
-0.0007391942199319601,
-0.014087945222854614,
0.015362237580120564,
0.005738017614930868,
0.00603344663977623,
-0.027526117861270905,
0.011467654258012772,
0.013356881216168404,
-0.007441431749612093,
-0.002291132230311632,
0.013635716401040554,
-0.009337415918707848,
0.012191460467875004,
-0.037296146154403687,
-0.03136682137846947,
0.01820368878543377,
-0.01847989857196808,
-0.004495228175073862,
0.016278086230158806,
-0.006212504580616951,
0.019697219133377075,
-0.014075846411287785,
0.0068306345492601395,
-0.000942782498896122,
0.007921440526843071,
-0.007918338291347027,
0.00977783277630806,
0.014335708692669868,
-0.0061615267768502235,
-0.002798542845994234,
0.007297389209270477,
-0.015468982979655266,
0.011648157611489296,
0.0006770382169634104,
-0.005533123388886452,
0.022670503705739975,
0.0070008994080126286,
0.014222068712115288,
-0.014142042025923729,
0.023263797163963318,
-0.005696703679859638,
-0.0005400225054472685,
-0.015423174947500229,
0.02460985630750656,
0.00087307533249259,
0.01181178167462349,
-0.010352442041039467,
-0.003598456969484687,
-0.006109368056058884,
0.0066337017342448235,
0.0033205286599695683,
0.00787781085819006,
0.008821048773825169,
0.03415536880493164,
0.0035470500588417053,
0.007085711695253849,
0.00461562629789114,
0.0002865015994757414,
0.021513160318136215,
0.005136549472808838,
-0.02174479514360428,
0.0008624540641903877,
-0.0199748445302248,
-0.003009083680808544,
0.02856692112982273,
-0.010869300924241543,
0.01578499749302864,
0.03199191763997078,
-0.023504260927438736,
-0.05735745280981064,
0.007283545099198818,
0.00937262736260891,
0.01738486811518669,
-0.0034100087359547615,
0.0034428341314196587,
-0.005307553336024284,
0.026928555220365524,
-0.013454766944050789,
-0.009337658062577248,
0.0005207292269915342,
-0.002019563689827919,
0.019696466624736786,
-0.001350827980786562,
-0.018936529755592346,
-0.012121593579649925,
0.003549276851117611,
0.0032061664387583733,
0.0004063611850142479,
0.012955908663570881,
-0.002138580195605755,
0.002378250705078244,
0.030721889808773994,
-0.018012311309576035,
0.006781172472983599,
-0.012822495773434639,
0.011827809736132622,
-0.008962146006524563,
-0.0038338261656463146,
0.008300642482936382,
-0.00464420672506094,
0.001464858534745872,
0.01602388359606266,
0.009906206279993057,
0.010116354562342167,
0.0029538231901824474,
0.03143545985221863,
0.008979786187410355,
-0.0036589475348591805,
0.00101536326110363,
0.004828359931707382,
0.0036824296694248915,
-0.008296020328998566,
-0.00803573988378048,
0.024401621893048286,
0.013705190271139145,
-0.013246972113847733,
-0.008533446118235588,
-0.00799112394452095,
-0.01119931973516941,
-0.014367563650012016,
0.004665177781134844,
0.015431433916091919,
0.008784806355834007,
0.025488507002592087,
-0.004557902924716473,
-0.012499289587140083,
0.0011190148070454597,
-0.0037870057858526707,
0.024181462824344635,
0.00470008235424757,
-0.032339178025722504,
0.03238888829946518,
-0.017040163278579712,
-0.007896671071648598,
-0.015160489827394485,
-0.001651765312999487,
0.0006646179826930165,
0.032723117619752884,
0.016408763825893402,
-0.011843133717775345,
0.01436489075422287,
-0.0089495200663805,
-0.011538546532392502,
0.02232605591416359,
-0.0007536716293543577,
-0.028552383184432983,
0.0024023393634706736,
0.005681267473846674,
0.003319404786452651,
-0.018787099048495293,
-0.019229669123888016,
0.004538147710263729,
-0.00888781063258648,
0.0055011906661093235,
0.015325305983424187,
-0.023892465978860855,
0.0033973667304962873,
0.004659685306251049,
0.02882053703069687,
-0.010052129626274109
] | [
0.2838800847530365,
-0.2737717032432556,
-0.3129410445690155,
0.17972353100776672,
0.08503694087266922,
0.5152782201766968,
0.024598227813839912,
0.006130542606115341,
0.1193167120218277,
-0.263462632894516,
-0.016904199495911598,
0.626319944858551,
0.10133865475654602,
0.3102445900440216,
-0.5977945923805237,
0.42350250482559204,
0.6972848773002625,
0.0783258005976677,
-0.18722693622112274,
-0.3727407157421112,
-0.4366935193538666,
-0.5843691825866699,
0.0202607624232769,
0.0666830912232399,
-0.36795929074287415,
0.4957723319530487,
0.3870175778865814,
-0.4222215414047241,
0.3237355649471283,
-0.2265063375234604,
0.40470895171165466,
0.23181495070457458,
0.2541092038154602,
-0.4552745223045349,
-0.006636345759034157,
-0.08461595326662064,
-0.3967064619064331,
-0.11316099017858505,
-0.4008585214614868,
-0.42234376072883606,
-0.40265119075775146,
-0.15335093438625336,
0.3705374002456665,
-0.006168293301016092,
0.05873948708176613,
-0.007694656495004892,
-1.1302483081817627,
0.3810728192329407,
-0.2108684778213501,
0.12163202464580536,
-0.10725217312574387,
0.020518239587545395,
0.33484846353530884,
0.6845724582672119,
0.07630845904350281,
0.0049278573133051395,
-0.3427393436431885,
-0.4277227222919464,
-0.05320660024881363,
-0.3246725797653198,
-0.18701641261577606,
0.12652915716171265,
0.38000035285949707,
0.5169599056243896,
-0.2196587175130844,
-0.2290821075439453,
-0.36645612120628357,
0.22613948583602905,
-0.21770590543746948,
-0.5640742778778076,
-0.22130246460437775,
-0.3178097903728485,
0.23493914306163788,
0.06942065805196762,
-0.11854282021522522,
0.20329949259757996,
-0.16606877744197845,
-0.5942333340644836,
0.7258579134941101,
-0.42672500014305115,
0.08462554216384888,
0.2087973803281784,
-0.1937101185321808,
-0.11180628836154938,
0.5638238191604614,
0.10587318986654282,
0.19873258471488953,
0.6271787881851196,
0.1729315221309662,
0.0683172270655632,
-0.040796130895614624,
0.12345528602600098,
0.5002097487449646,
-0.17092357575893402,
-0.24090974032878876,
0.290468692779541,
0.22104474902153015,
-0.33780020475387573,
0.27497246861457825,
-0.1665809601545334,
-0.40154141187667847,
0.08774394541978836,
0.0012195531744509935,
-0.05377718806266785,
-0.5439477562904358,
-0.21262018382549286,
0.37498950958251953,
-0.2346230000257492,
-0.579486072063446,
0.4461959898471832,
-0.23924055695533752,
0.35369086265563965,
-0.02988540567457676,
0.02197490632534027,
-0.3532140552997589,
0.08118446916341782,
0.15719947218894958,
0.09034623950719833,
-0.32165446877479553,
-0.32577311992645264,
-0.2983247637748718,
0.3378913998603821,
0.09508929401636124,
0.042415812611579895,
0.3681507110595703,
0.32165592908859253,
0.4736977219581604,
0.45689162611961365,
-0.11346566677093506,
0.12422347813844681,
0.16525954008102417,
0.5098526477813721,
-0.09426557272672653,
-0.44668644666671753,
0.014505899511277676,
-0.16640305519104004,
0.07425346970558167,
-0.13068482279777527,
0.3927672803401947,
0.14941921830177307,
-0.1553940773010254,
-0.21369999647140503,
0.1028687134385109,
-0.139709010720253,
0.20266442000865936,
0.03258568421006203,
0.30603402853012085,
0.34234902262687683,
-0.44103243947029114,
0.04619692265987396,
0.09746714681386948,
-0.04268268495798111,
-0.038292013108730316,
-0.6399592161178589,
0.2191280722618103,
0.3103964030742645,
-0.10931121557950974,
0.06455127894878387,
-0.6014143228530884,
0.22292010486125946,
0.3735596537590027,
0.22742334008216858,
-0.46070006489753723,
0.10119535028934479,
0.673379123210907,
-0.31664928793907166,
-0.08290380239486694,
0.5012677311897278,
0.19472387433052063,
0.47302761673927307,
-0.5075277090072632,
0.26137882471084595,
-0.17895594239234924,
-1.03336501121521,
-0.13387486338615417,
0.492666631937027,
0.3502843677997589,
0.09669603407382965,
0.19681385159492493,
-0.1350744664669037,
-0.6338596940040588,
0.6723091006278992,
0.19912146031856537,
-0.5258006453514099,
0.03275298699736595,
-0.37619850039482117,
0.5303578972816467,
-0.4382172226905823,
-0.05064285919070244,
-0.0674716904759407,
-0.8781996965408325,
-0.13024497032165527,
0.5359111428260803,
-0.3957942724227905,
1.4948135614395142,
-0.10396618396043777,
0.04467033967375755,
1.6029068231582642,
0.039582882076501846,
-0.28040552139282227,
-0.16234922409057617,
0.15271322429180145,
0.2265975922346115,
-0.1507866084575653,
-1.4298752546310425,
0.1510610282421112,
0.11060040444135666,
-0.41196492314338684,
-0.39856523275375366,
-0.05577070266008377,
0.4502856731414795,
0.06360756605863571,
-0.17721140384674072,
-0.01585705578327179,
0.0791134461760521,
-0.28712111711502075,
0.10455349832773209,
0.3647497892379761,
0.40920335054397583,
-0.7544795870780945,
0.2880536615848541,
-0.41017237305641174,
0.32050517201423645,
1.0035072565078735,
0.0740666389465332,
0.6416058540344238,
0.45791175961494446,
0.13229721784591675,
0.5691755414009094,
-0.13149887323379517,
0.16128414869308472,
0.3005681335926056,
0.12723124027252197,
-0.3231585621833801,
0.3388001620769501,
0.517020046710968,
-0.3928254544734955,
-0.4800782799720764,
0.11927147209644318,
0.04011864587664604,
-0.296118825674057,
-0.3562653362751007,
-0.41963863372802734,
0.4628274738788605,
0.21737657487392426,
-0.24027270078659058,
-0.8676689267158508,
0.5448739528656006,
-0.6250306367874146,
0.216575488448143,
-0.233049213886261,
0.3737752437591553,
0.2413463294506073,
0.03997496888041496,
-0.05378062278032303,
0.03944062814116478,
-0.06127554178237915,
-0.2458934634923935,
0.18711745738983154,
-0.429566353559494,
-0.21695253252983093,
0.31630563735961914,
0.0583091676235199,
0.12400196492671967,
0.10228483378887177,
-0.6528753638267517,
-0.4562443792819977,
-0.16487033665180206,
0.064567930996418,
0.28564348816871643,
-0.006998566444963217,
-0.2058069258928299,
-1.0189744234085083,
-0.18300224840641022,
-0.2688591182231903,
-0.533963143825531,
-0.09007328748703003,
0.9223899245262146,
-0.0503619946539402,
-0.2684358060359955,
-0.1594679355621338,
-0.07636810094118118,
0.5233483910560608,
-0.34286803007125854,
-0.054994720965623856,
0.20814037322998047,
-0.14442265033721924,
-0.6384105086326599,
-0.31473276019096375,
-0.08489880710840225,
0.020083000883460045,
0.6218896508216858,
-0.14328955113887787,
0.09640799462795258,
0.5728803277015686,
0.3811376690864563,
-0.29221880435943604,
0.1754719614982605,
0.45422670245170593,
-0.16659840941429138,
0.21429572999477386,
0.06634766608476639,
0.7006903886795044,
0.15087035298347473,
0.10368259251117706,
-0.06581063568592072,
0.06064746528863907,
-0.3600814938545227,
-6.044034957885742,
-0.2861957550048828,
-0.22042414546012878,
-0.4247789680957794,
-0.015151001513004303,
0.3435533046722412,
1.0917991399765015,
0.009292344562709332,
0.006856772117316723,
0.5657647252082825,
0.21934206783771515,
0.4910968244075775,
-0.050775203853845596,
0.3216835558414459,
0.4724373519420624,
0.48070383071899414,
-0.09467896074056625,
-0.25721314549446106,
0.3049076199531555,
0.15756922960281372,
0.5314993858337402,
-0.22732461988925934,
0.09363424777984619,
0.5030909180641174,
-0.032056741416454315,
0.2666991353034973,
-0.6087648272514343,
0.2696398198604584,
-0.54664146900177,
-0.12509354948997498,
0.41926929354667664,
-0.18728509545326233,
0.05382683128118515,
0.13090461492538452,
-0.10592702776193619,
0.33009961247444153,
0.356950581073761,
0.14955364167690277,
-0.1889188587665558,
-0.12085509300231934,
0.19866034388542175,
-0.04551069065928459,
0.2292155623435974,
-0.4541972875595093,
-0.1695173978805542,
0.19348938763141632,
0.41457900404930115,
0.0865350067615509,
-0.33701565861701965,
1.2781081199645996,
0.22825665771961212,
-0.04353542625904083,
-0.07153700292110443,
0.19831566512584686,
0.023973997682332993,
0.0035978478845208883,
0.021922940388321877,
-0.054352760314941406,
-0.6432653665542603,
0.21438924968242645,
-0.6693042516708374,
-0.06787356734275818,
-0.25538840889930725,
-0.7412164807319641,
0.5599276423454285,
-0.08013954758644104,
-0.6233701109886169,
-0.36985304951667786,
0.37007832527160645,
0.48138877749443054,
-0.20683221518993378,
0.22996562719345093,
0.19835510849952698,
-0.5767360329627991,
0.09076423943042755,
-0.9659501314163208,
0.09061101824045181,
0.055053628981113434,
0.15716424584388733,
-0.053937289863824844,
0.18486762046813965,
-0.4455021023750305,
0.15237592160701752,
-0.08534976840019226,
0.1633445918560028,
0.053800251334905624,
-0.27974802255630493,
0.0670260563492775,
-0.10487058758735657,
0.10421822965145111,
0.33479171991348267,
-0.02358035370707512,
-0.4342663586139679,
0.09599053114652634,
0.006647741422057152,
0.5992456078529358,
0.33472558856010437,
0.6997512578964233,
-0.01579914428293705,
-0.07043970376253128,
0.28501614928245544,
0.12072031944990158,
-0.11841798573732376,
-0.641623318195343,
-0.40983274579048157,
-0.2989281415939331,
-0.44061732292175293,
-0.1034427061676979,
0.2885490655899048,
-0.8843331933021545,
0.17906837165355682,
0.03578014299273491,
-0.20109105110168457,
-0.5827777981758118,
0.24730387330055237,
0.17387604713439941,
0.25079545378685,
0.12456116080284119,
0.3311081826686859,
-0.24584504961967468,
0.4745689928531647,
0.11508551239967346,
-0.4891187846660614,
-0.05587763339281082,
-0.2903847396373749,
-0.3997249901294708,
0.12987090647220612,
0.4907687306404114,
-0.4865085184574127,
0.5630800724029541,
0.020313560962677002,
0.2766807973384857,
-0.3034970462322235,
-0.08307472616434097,
-0.03918283060193062,
-0.2824690341949463,
-0.3638377785682678,
0.7642443180084229,
-0.4205983877182007,
0.3833191990852356,
-0.18924246728420258,
0.09265605360269547,
-0.2849246561527252,
-0.36207112669944763,
0.03543447330594063,
-0.3391786217689514,
-0.008358409628272057,
-0.2073659747838974,
0.23889635503292084,
-0.07003604620695114,
0.16504840552806854,
-0.024180244654417038,
0.3366824984550476,
0.2906542122364044,
-0.16575837135314941,
0.002165263518691063,
0.3331250250339508,
0.01700047217309475,
-0.16238224506378174,
-0.5063973069190979,
-0.14455623924732208,
0.04405447095632553,
-1.440077781677246,
-0.8636358976364136,
0.3343529999256134,
-0.22040444612503052,
-0.1716640442609787,
-0.9429377913475037,
-0.11117316037416458,
0.10670532286167145,
0.060758624225854874,
-0.26878783106803894,
-0.4381589889526367,
0.22101719677448273,
0.29435861110687256,
0.03616135194897652,
0.13650961220264435,
-0.410415381193161,
-0.3833429217338562,
-0.151774600148201,
0.2508934438228607,
-0.49941208958625793,
-0.09285663813352585,
-0.05693500488996506,
0.5863597393035889,
-0.16239212453365326,
-0.22286945581436157,
0.04984312877058983,
-0.2817413806915283,
0.2731548547744751,
0.35318344831466675,
-0.3552466630935669,
0.4796263873577118,
-0.09044940024614334,
-0.07180879265069962,
0.10835643857717514,
-0.14741340279579163,
0.39981919527053833,
0.22920803725719452,
0.20485827326774597,
-0.38416770100593567,
0.22357672452926636,
-0.30088910460472107,
0.07917928695678711,
0.5098694562911987,
-0.07000557333230972,
0.2062288522720337,
-0.042591653764247894,
-0.5860571265220642,
-0.005427790805697441,
-0.2656494379043579,
-0.004819622728973627,
0.21907733380794525,
0.15003134310245514,
-0.5576689839363098,
0.05401832237839699,
-0.19000612199306488,
-0.5540652871131897,
-0.5103809833526611,
-0.16136513650417328,
0.620137631893158,
-0.1425057053565979,
-0.4157470762729645,
-0.045094847679138184,
-0.29639437794685364,
-0.2604353725910187,
0.3838014602661133,
-0.8601370453834534,
0.2473275363445282,
0.5899366736412048,
-0.7569012641906738,
-0.26920372247695923,
0.058102481067180634,
-0.0818413496017456,
-0.28645268082618713,
-0.20751453936100006,
-0.46474871039390564,
0.5158759355545044,
-0.04576028510928154,
-0.16860811412334442,
0.14798510074615479,
0.3989514708518982,
-0.09846736490726471,
-0.09692320972681046,
0.13159425556659698,
0.27453646063804626,
0.25166788697242737,
-0.7440486550331116,
-0.1690751016139984,
0.5420907735824585,
0.09511934965848923,
-0.4311866760253906,
-0.3109174370765686,
-0.10149071365594864,
0.11749333888292313,
0.1924031674861908,
-0.2578445076942444,
-0.5125388503074646,
0.033416036516427994,
0.8632867932319641,
-0.13664081692695618,
-0.15702266991138458,
-0.10032470524311066,
0.20012594759464264,
0.2526417374610901,
0.30065879225730896,
0.19368188083171844,
-0.6491358876228333,
-0.294717401266098,
-0.31211909651756287,
0.5649991035461426,
-0.35509613156318665,
0.9677609801292419,
0.3852236270904541,
0.26669496297836304,
-0.04799726977944374,
-0.28321871161460876,
0.04515353962779045,
0.3408525288105011,
0.306819885969162,
0.15512073040008545,
-0.4020410180091858,
0.24005860090255737,
0.05931070074439049,
0.0293143168091774,
-0.6135426163673401,
0.13356338441371918,
-0.15065191686153412,
-0.3731810450553894,
-0.06709591299295425,
-0.08523818850517273,
0.23946534097194672,
-0.5610640645027161,
-0.24345238506793976,
0.12402603775262833,
-0.21786797046661377,
0.05869336053729057,
0.6560512781143188,
0.16566212475299835,
-0.10576614737510681,
-0.04193847253918648,
0.2404775321483612,
0.716709554195404,
-0.5358014702796936,
0.16417336463928223,
0.67965167760849,
-0.26009079813957214,
-0.24486568570137024,
-0.5693168640136719,
0.541388213634491,
0.10901182889938354,
-0.2141440212726593,
0.4357329308986664,
0.365865558385849,
-0.6212078332901001,
-0.09161936491727829,
-0.27409037947654724,
-0.03468356281518936,
0.2735803425312042,
-0.18145348131656647,
0.05466608330607414,
0.7562146782875061,
0.6202816367149353,
-0.4196957051753998,
-0.3235398828983307,
0.3195786476135254,
-0.08454172313213348,
0.2933986485004425,
0.08179762214422226,
0.5728577375411987,
0.6011093258857727,
0.7209076881408691,
0.3813339173793793,
0.5413550734519958,
-0.11091772466897964,
-0.07258044928312302,
-0.1536206156015396,
-0.658077597618103,
-0.10819606482982635,
-0.009931201115250587,
0.8457789421081543,
-0.15961380302906036,
0.6087768077850342,
0.3651224672794342,
0.2257547527551651,
0.858465850353241,
0.7732383608818054,
0.24785323441028595,
0.05202803388237953,
-0.011694311164319515,
0.16204459965229034,
-0.7514086961746216,
0.12696853280067444,
0.25756463408470154,
-0.26842913031578064,
-0.03540574386715889,
0.4637291133403778,
-0.005099073518067598,
-0.3144647777080536,
-0.08337501436471939,
-0.3682481348514557,
-0.1145244762301445,
-0.45179328322410583,
0.016355670988559723,
0.27741315960884094,
-0.182365283370018,
1.0414414405822754,
0.3862614333629608,
0.2015007734298706,
0.05050169304013252,
-0.12263456732034683,
0.09365951269865036,
-0.4618939757347107,
0.4740377366542816,
0.2320924550294876,
-0.9856815338134766,
0.29966941475868225,
0.3092724680900574,
0.13554500043392181,
0.18839743733406067,
-0.15758170187473297,
-0.39665487408638,
0.041482117027044296,
-0.4791608154773712,
-0.13378047943115234,
-0.08133947849273682,
-0.4455362558364868,
-0.11855769157409668,
-0.15790516138076782,
0.1682537943124771,
-0.08535310626029968,
-0.3857455551624298,
0.25537213683128357,
0.05142052844166756,
-0.06019200384616852,
0.06823588162660599,
0.007898634299635887,
-0.054591104388237,
0.4647427499294281,
0.31392961740493774,
-0.5360918045043945,
0.14104637503623962,
-0.2873143255710602,
-0.1526980996131897,
0.10701564699411392,
0.2580539584159851,
-0.14972352981567383,
-0.11584391444921494,
-0.41003987193107605,
-0.1941257268190384,
0.3866645395755768,
0.5963481664657593,
-0.3208586573600769,
0.3803785741329193,
-0.1609228551387787,
0.14771555364131927,
0.8518921732902527,
-0.39676883816719055,
-0.16619904339313507,
-0.6997997164726257,
-0.3787471055984497,
-0.1289682239294052,
0.7859426736831665,
-0.2634274661540985,
-0.043297674506902695,
0.20295490324497223,
0.38611215353012085,
0.592457115650177,
0.005497652571648359,
0.3683931827545166,
-0.47019413113594055,
-0.23723186552524567,
-0.36486080288887024,
0.4540456235408783,
-0.2164766937494278,
0.10091204196214676,
0.07714307308197021,
0.10689808428287506,
0.15924464166164398,
-0.37197670340538025,
-0.1281268447637558,
-0.5611463189125061,
-0.10163768380880356,
-0.07763125747442245,
0.30987870693206787,
0.23498445749282837,
-0.1341371238231659,
0.02585500292479992,
-0.5835480093955994,
-0.21123668551445007,
-0.13378286361694336,
-0.6360236406326294,
-0.39892035722732544,
-0.033712878823280334,
-0.05203917995095253,
-0.5897338390350342,
-0.4556821286678314,
-0.33137214183807373,
-0.4205692410469055,
-0.041230786591768265
] |
Abstract A woman, now 59 has been followed for 13 years with several manifestations of Behcet's disease. These were aphthous stomatitis, genital ulcers, uveitis causing blindness, recurrent erythema nodosum, and synovitis. In 1970 a poorly differentiated diffuse lymphocytic lymphoma appeared and was treated with radiotherapy. In 1976 she developed a mixed cryoglobulinemia and an immune complex mediated vasculitis manifested by purpura and neuropathy which improved on prednisone and chlorambucil therapy. The subsequent course of her lymphoproliferative disorder suggest that it was in fact benign. | [
0.0017655708361417055,
0.003984851762652397,
-0.01665564253926277,
-0.0038726762868463993,
0.0031547853723168373,
-0.006485879421234131,
0.008547615259885788,
0.03205893188714981,
-0.011880658566951752,
0.01548121776431799,
-0.011183515191078186,
0.013897808268666267,
-0.015490129590034485,
-0.008672392927110195,
-0.007180654443800449,
0.004161815624684095,
-0.020279541611671448,
0.007620777934789658,
0.01455727405846119,
0.011124974116683006,
0.0063976203091442585,
-0.013527636416256428,
0.009507237002253532,
-0.0031364033930003643,
-0.020712196826934814,
0.02175987884402275,
-0.014449427835643291,
-0.010806874372065067,
-0.01846655085682869,
-0.012490801513195038,
0.023802582174539566,
0.0023931029718369246,
-0.009937810711562634,
-0.012840447016060352,
-0.019777996465563774,
-0.014233872294425964,
-0.0016385705675929785,
0.008879821747541428,
-0.01894323155283928,
-0.005445138085633516,
-0.0011641457676887512,
-0.009384574368596077,
0.004801157861948013,
-0.005156214814633131,
-0.0077729723416268826,
-0.022634431719779968,
-0.007854295894503593,
-0.0242051649838686,
0.014207055792212486,
0.004406888037919998,
-0.010041085071861744,
-0.015792712569236755,
-0.007562463171780109,
-0.008305219002068043,
-0.005465620197355747,
-0.005455044563859701,
0.016838956624269485,
0.0040037669241428375,
0.013128940016031265,
0.021538902074098587,
-0.000623258063569665,
-0.01483209989964962,
0.015016383491456509,
-0.005726499017328024,
-0.011538760736584663,
-0.06732605397701263,
0.016348253935575485,
-0.015311846509575844,
-0.005576782859861851,
-0.02194211445748806,
-0.008724269457161427,
0.009254549629986286,
-0.009356183931231499,
0.005313257686793804,
-0.008786007761955261,
0.005175775848329067,
0.0022716615349054337,
0.022890262305736542,
0.0022676894441246986,
0.0015123034827411175,
0.004457567818462849,
-0.005919931456446648,
-0.026309426873922348,
0.01924363151192665,
0.007668958976864815,
-0.00607394939288497,
-0.013395245186984539,
0.011684943921864033,
-0.012222779914736748,
-0.03552304208278656,
-0.01114516519010067,
-0.018032072111964226,
-0.02192089334130287,
-0.014597428031265736,
0.0014833107125014067,
-0.013336570002138615,
0.003491546493023634,
0.011720703914761543,
0.002433592453598976,
-0.002802899107336998,
-0.005233753006905317,
0.014662097208201885,
0.017786044627428055,
0.0026019858196377754,
0.022280503064393997,
0.00034846662310883403,
-0.015575654804706573,
-0.012645619921386242,
0.00522759510204196,
0.010141272097826004,
-0.0030586158391088247,
-0.000294240890070796,
0.03328967094421387,
0.0066815754398703575,
0.017567232251167297,
-0.01939116232097149,
-0.001091789803467691,
-0.00020729145035147667,
0.008610600605607033,
-0.020311838015913963,
-0.0016977423802018166,
-0.02488655224442482,
-0.00006638234481215477,
-0.00427530612796545,
-0.004770149476826191,
-0.015812048688530922,
-0.0008038030937314034,
-0.006099553778767586,
-0.0040124161168932915,
-0.011762674897909164,
-0.0036640651524066925,
-0.0038628901820629835,
-0.0032936888746917248,
-0.022072870284318924,
-0.018060985952615738,
-0.007273799739778042,
-0.007516162004321814,
-0.013438285328447819,
-0.014346086420118809,
-0.006216153968125582,
-0.014515938237309456,
0.009174028411507607,
0.0017631723312661052,
0.005426660180091858,
-0.0065988702699542046,
-0.002547969575971365,
-0.013350243680179119,
-0.006967809051275253,
0.006037968676537275,
-0.01548677682876587,
0.0036623631604015827,
0.01569926179945469,
-0.012662889435887337,
-0.0028990302234888077,
-0.005373083986341953,
0.03153510019183159,
-0.036466777324676514,
-0.017437515780329704,
0.019572462886571884,
0.002919616177678108,
-0.000571979209780693,
-0.0024739063810557127,
-0.00863915216177702,
0.009752422571182251,
0.01706087961792946,
0.011866724118590355,
0.0004941890947520733,
0.009960842318832874,
0.015250482596457005,
0.0016318716807290912,
-0.0032553323544561863,
-0.0113224470987916,
-0.01572311855852604,
0.011775371618568897,
-0.011247940361499786,
-0.01599963940680027,
0.019148681312799454,
0.004320058971643448,
0.0014932499034330249,
0.06613034009933472,
-0.01912926509976387,
-0.0021702495869249105,
-0.029589839279651642,
0.005493356846272945,
0.01268751546740532,
0.013500121422111988,
0.021844495087862015,
-0.010222412645816803,
-0.0038332869298756123,
-0.0034127470571547747,
-0.0033462096471339464,
0.03139932453632355,
-0.0016585306730121374,
-0.0028778761625289917,
-0.01040053553879261,
0.0030573683325201273,
0.022478565573692322,
0.004704969469457865,
0.005161532200872898,
0.037101082503795624,
0.013045035302639008,
0.021505363285541534,
0.01522879209369421,
-0.008247073739767075,
-0.008066763170063496,
0.02641255035996437,
0.013567685149610043,
-0.003669571131467819,
-0.011466019786894321,
-0.007229900453239679,
0.010368496179580688,
-0.0022790427319705486,
0.0033521961886435747,
-0.003938570618629456,
0.0027519359719008207,
-0.0018893491942435503,
-0.010078688152134418,
0.0021820212714374065,
-0.010896384716033936,
-0.013628300279378891,
-0.001057649147696793,
-0.0037533671129494905,
0.007352142129093409,
0.008373385295271873,
-0.00288190646097064,
-0.0014862348325550556,
0.020427865907549858,
0.013103829696774483,
0.028517339378595352,
0.007924189791083336,
-0.02437271550297737,
-0.006311439443379641,
-0.01044371910393238,
0.018223192542791367,
0.022919265553355217,
-0.0004251778591424227,
0.014328736811876297,
-0.002795287873595953,
0.01153581216931343,
-0.020334310829639435,
-0.007016273215413094,
-0.01899578608572483,
0.0017094993963837624,
0.01593758724629879,
0.03019120544195175,
-0.009406868368387222,
0.0038686287589371204,
-0.004826701246201992,
-0.017943166196346283,
-0.005243198946118355,
0.006057457998394966,
0.012039167806506157,
0.006309468299150467,
0.015449220314621925,
0.001469703041948378,
-0.020884456112980843,
0.015424078330397606,
-0.0030742997769266367,
0.025931812822818756,
-0.013124007731676102,
0.012319065630435944,
0.0030507436022162437,
0.0030908784829080105,
0.0030351111199706793,
0.004915749188512564,
-0.006175564602017403,
0.004168222192674875,
-0.009420523419976234,
0.0012636678293347359,
0.011252344585955143,
0.010574225336313248,
-0.010460978373885155,
0.0014422294916585088,
-0.08181138336658478,
-0.011777287349104881,
-0.0027043407317250967,
-0.0071669453755021095,
0.0038363586645573378,
-0.012444093823432922,
-0.008472496643662453,
0.0004938347265124321,
0.006124896463006735,
0.0033188972156494856,
0.015872228890657425,
-0.0018995795398950577,
0.0005795689066872001,
-0.018718404695391655,
0.00614391453564167,
0.002140253549441695,
0.005684284958988428,
-0.0251002199947834,
-0.005553569179028273,
-0.018292570486664772,
0.018102675676345825,
0.020829951390624046,
0.03217252343893051,
0.00568680465221405,
-0.027919091284275055,
0.03475959971547127,
0.013399996794760227,
-0.008122988976538181,
0.024118460714817047,
0.01821564882993698,
0.0049249231815338135,
-0.013763997703790665,
0.006498478353023529,
0.006263343617320061,
0.011626164428889751,
-0.010814529843628407,
-0.032566968351602554,
0.0003855866380035877,
0.002471647225320339,
0.024090776219964027,
-0.016337139531970024,
0.005538368131965399,
0.005590107757598162,
-0.008675475604832172,
0.01276345457881689,
0.021227629855275154,
0.009260209277272224,
-0.00735800014808774,
0.020204193890094757,
0.008589640259742737,
-0.005355434026569128,
0.010895488783717155,
-0.0169095266610384,
0.012505518272519112,
-0.009253558702766895,
-0.028081204742193222,
0.00864827074110508,
0.000844260212033987,
0.0008347977418452501,
-0.008055619895458221,
0.009907335974276066,
-0.019674360752105713,
0.009384376928210258,
-0.005289784166961908,
-0.005016692914068699,
0.0073657347820699215,
0.003847680287435651,
0.017878659069538116,
-0.003970665857195854,
0.01153445616364479,
-0.005213079508394003,
0.00797317922115326,
0.009693486616015434,
-0.01226961612701416,
0.0014683387707918882,
0.004902907181531191,
-0.013418604619801044,
-0.003458521794527769,
-0.0020692222751677036,
0.006015856750309467,
0.002145229373127222,
0.001440058695152402,
0.0038298664148896933,
0.015524134039878845,
-0.006010855548083782,
-0.01131662167608738,
0.009680531919002533,
0.0343095064163208,
0.007505820132791996,
-0.017131101340055466,
0.0018203037325292826,
-0.007101348601281643,
-0.009648889303207397,
0.014238067902624607,
0.018209286034107208,
-0.00446734856814146,
0.005443663336336613,
-0.008684496395289898,
0.010558564215898514,
0.004840418230742216,
-0.003452297765761614,
-0.01855425536632538,
0.001969633623957634,
-0.0030675388406962156,
-0.017161287367343903,
0.0063033755868673325,
0.009394180029630661,
-0.001382279908284545,
0.0004030521959066391,
-0.0066870455630123615,
0.008887851610779762,
-0.012576211243867874,
-0.0028289451729506254,
0.006093420088291168,
0.01000726968050003,
0.022621456533670425,
0.016747698187828064,
-0.011686762794852257,
0.07296977937221527,
-0.006258208304643631,
0.0022739546839147806,
-0.010419885627925396,
0.005621895659714937,
-0.020080655813217163,
-0.002265022136271,
0.0005995011888444424,
-0.021425751969218254,
0.00855286419391632,
0.013006509281694889,
0.009503858163952827,
0.0032393313013017178,
-0.02175012230873108,
-0.0026810034178197384,
-0.0055112880654633045,
-0.0005361966323107481,
0.003090175800025463,
-0.002809641882777214,
0.002648203866556287,
0.008761703036725521,
-0.01588786207139492,
-0.008346379734575748,
0.0061645652167499065,
0.022800829261541367,
-0.004890830721706152,
0.018207203596830368,
-0.010081380605697632,
-0.006480674259364605,
0.010049806907773018,
-0.027935896068811417,
-0.0005183015018701553,
-0.009923113510012627,
-0.005371961742639542,
0.008807104080915451,
-0.020860860124230385,
-0.011857625097036362,
0.004710758104920387,
-0.0031718125101178885,
-0.0013309908099472523,
-0.004088736139237881,
-0.009365028701722622,
-0.024107571691274643,
0.0021360560785979033,
0.007630867883563042,
0.027012210339307785,
0.03591344505548477,
-0.008599412627518177,
-0.007686455734074116,
-0.022766882553696632,
-0.01223214901983738,
0.009798422455787659,
0.01238279789686203,
-0.018457144498825073,
-0.02077353373169899,
-0.013336973264813423,
-0.024179846048355103,
-0.006204604171216488,
-0.0049482230097055435,
-0.005208038724958897,
-0.015686700120568275,
-0.01583687588572502,
-0.017594702541828156,
0.00091215455904603,
0.005845055915415287,
-0.008686209097504616,
0.006925676017999649,
-0.00035130028845742345,
0.0019947513937950134,
0.006383324041962624,
-0.007476694416254759,
-0.007057569455355406,
-0.005214286968111992,
0.01969628408551216,
-0.010581741109490395,
0.0063905357383191586,
-0.0023287911899387836,
0.02290981262922287,
0.017072666436433792,
-0.025013873353600502,
-0.005475920159369707,
0.014121334999799728,
0.012655872851610184,
-0.034679558128118515,
0.0159916914999485,
0.020181745290756226,
0.01872253231704235,
-0.07543007284402847,
-0.004135521128773689,
-0.016755811870098114,
-0.007506922818720341,
0.002926088869571686,
-0.0028021184261888266,
-0.018095482140779495,
0.015837255865335464,
-0.013977996073663235,
0.004764892160892487,
-0.007575883064419031,
0.017255276441574097,
-0.0009840193670243025,
0.014153658412396908,
0.013974991627037525,
0.013017398305237293,
-0.0020445266272872686,
-0.010434838011860847,
-0.0036372423637658358,
0.013432762585580349,
0.01299988478422165,
-0.004855278879404068,
-0.021992286667227745,
0.008948400616645813,
-0.0036951638758182526,
-0.0818345919251442,
0.009160943329334259,
-0.030645955353975296,
0.008103526197373867,
-0.005959024652838707,
0.00868973322212696,
-0.014118490740656853,
-0.0140857407823205,
0.0015808932948857546,
-0.013287453912198544,
0.008605473674833775,
0.004300622269511223,
0.011917591094970703,
-0.01656200736761093,
-0.0021807216107845306,
-0.00503744650632143,
0.00738442363217473,
0.008475551381707191,
-0.02005706913769245,
-0.02381526492536068,
-0.0072604017332196236,
-0.0021677918266505003,
0.0009060302400030196,
0.008097715675830841,
-0.0036854888312518597,
0.0043386719189584255,
-0.007654829416424036,
0.0055876076221466064,
-0.006472722627222538,
-0.004685688763856888,
0.0025271489284932613,
0.0028753182850778103,
-0.023351984098553658,
0.006883660331368446,
-0.004420249257236719,
-0.0030395418871194124,
0.026419438421726227,
0.00038033979944884777,
-0.005583081394433975,
-0.0027972934767603874,
0.0006775395595468581,
-0.000768971280194819,
0.014341840520501137,
0.003344364929944277,
0.013770260848104954,
0.031912147998809814,
0.00525693129748106,
-0.011841527186334133,
-0.004104097839444876,
0.001142389141023159,
0.0027728292625397444,
-0.026835571974515915,
0.0014523621648550034,
0.02714616060256958,
0.006633123382925987,
-0.0038617702666670084,
-0.0043786196038126945,
0.007898218929767609,
-0.021533366292715073,
0.009292331524193287,
-0.009400589391589165,
0.009782379493117332,
0.01429428905248642,
0.07110943645238876,
-0.0021966423373669386,
-0.0050646220333874226,
-0.009742053225636482,
-0.0030015793163329363,
0.006330569740384817,
-0.022433627396821976,
-0.009095962159335613,
0.0008744695223867893,
0.007201039232313633,
-0.008163366466760635,
-0.008228521794080734,
0.006323397159576416,
0.007265112828463316,
0.01392140332609415,
0.003365203505381942,
0.005667971447110176,
0.014869586564600468,
-0.013447959907352924,
-0.003858280600979924,
0.002020906424149871,
-0.0013374988920986652,
-0.015766171738505363,
-0.016834579408168793,
0.015619193203747272,
-0.0012280362425372005,
-0.005587420426309109,
0.0012785736471414566,
-0.021291052922606468,
-0.009997222572565079,
-0.006304913200438023,
0.03531651198863983,
0.008220408111810684,
0.011235151439905167,
0.009757325053215027,
-0.011719215661287308,
0.0001802239567041397,
0.016973335295915604,
0.01020047441124916,
0.007787360809743404,
0.00645521329715848,
0.0037290258333086967,
0.002253246260806918,
0.006607938092201948,
0.015387706458568573,
0.015983738005161285,
0.004884091671556234,
-0.010198192670941353,
0.009858903475105762,
0.001993986777961254,
-0.009586491622030735,
0.012822226621210575,
0.021258417516946793,
0.025972118601202965,
0.006586715579032898,
0.037515100091695786,
-0.0009329044260084629,
0.019049905240535736,
-0.0173618346452713,
-0.007535808719694614,
0.011215436272323132,
-0.011832337826490402,
0.02529052644968033,
-0.03134714812040329,
-0.011905648745596409,
0.01873829960823059,
0.013906488195061684,
-0.01481914333999157,
-0.026518957689404488,
0.007381106726825237,
-0.01470501720905304,
0.005937234032899141,
0.005338625051081181,
0.004346219822764397,
-0.0005757738836109638,
0.009941625408828259,
-0.0017598343547433615,
0.023519057780504227,
0.006377132143825293,
0.007221978157758713,
-0.0043932851403951645,
0.016493942588567734,
0.011847119778394699,
-0.0023585339076817036,
0.003947217017412186,
0.0037975460290908813,
0.002014871221035719,
-0.008453821763396263,
-0.00534176966175437,
0.006376809440553188,
0.030169684439897537,
0.00006665149703621864,
-0.000303984503261745,
0.012893821112811565,
0.012097075581550598,
0.03482549637556076,
-0.0026264460757374763,
0.000568728952202946,
0.003894053166732192,
0.001021845848299563,
-0.0013037403114140034,
-0.008222307078540325,
-0.02134900540113449,
0.006566917523741722,
-0.0031951633282005787,
-0.007929902523756027,
0.0034300293773412704,
0.0068910145200788975,
0.0018030870705842972,
0.020573686808347702,
0.009965846315026283,
0.015967709943652153,
-0.001231063506565988,
0.00003813742659986019,
0.0018942211754620075,
0.0025144850369542837,
-0.0038618389517068863,
-0.0016787932254374027,
-0.000739414943382144,
-0.01715659722685814,
0.017193248495459557,
-0.007023212034255266,
-0.0030595404095947742,
0.020909911021590233,
-0.043449003249406815,
0.011128075420856476,
-0.003887272672727704,
-0.0048183719627559185,
-0.005613843910396099,
-0.012091539800167084,
0.013283899053931236,
0.0003627622500061989,
-0.008395295590162277,
0.030307214707136154,
-0.004318786319345236,
-0.017998769879341125,
-0.004722615238279104,
-0.005306433420628309,
-0.008458221331238747,
-0.03131890296936035,
0.021084723994135857,
-0.0025250508915632963,
0.002701077377423644,
-0.002163238823413849,
0.010143924504518509,
-0.0047756824642419815,
-0.007332438603043556,
-0.004966557491570711,
0.017361018806695938,
-0.0013959415955469012,
-0.00401599146425724,
0.010193279944360256,
0.004453560337424278,
-0.0018175304867327213,
0.0015202624490484595,
0.007738451473414898,
0.015956126153469086,
0.03568430617451668,
-0.009589416906237602,
-0.013165423646569252,
-0.01593857631087303,
-0.009093164466321468,
0.00008949730545282364,
-0.011477388441562653,
0.004997529089450836,
0.004173637833446264,
0.0012201988138258457,
0.0004071720177307725,
0.009224753826856613,
0.0047121052630245686,
-0.002293079160153866,
-0.015461385250091553,
-0.01632601208984852,
0.011001531034708023,
-0.01898353546857834,
-0.0048337155021727085,
-0.011779848486185074,
-0.00350411469116807,
-0.018530305474996567,
-0.004575468599796295,
0.0026694254484027624,
0.005437957122921944,
0.011906977742910385,
-0.010339248925447464,
-0.008108321577310562,
-0.007664909586310387,
-0.0029097043443471193,
0.006627941038459539,
-0.006061007268726826,
0.012565595097839832,
0.00481077004224062,
-0.027957942336797714,
0.009906708262860775,
0.006322208326309919,
0.011753976345062256,
0.00870133750140667,
0.028342831879854202,
0.02254655584692955,
-0.012364384718239307,
0.007032316643744707,
-0.008980266749858856,
-0.012250765226781368
] | [
0.044657833874225616,
0.043716911226511,
0.26520898938179016,
-0.26032939553260803,
-0.5110905766487122,
0.5618133544921875,
-0.12409774214029312,
-0.31649091839790344,
-0.12399005889892578,
-0.3957851231098175,
0.3208429515361786,
0.018143808469176292,
-0.023665979504585266,
0.47465354204177856,
-0.03893892839550972,
0.30007484555244446,
0.037467047572135925,
0.11672159284353256,
-1.048230767250061,
-0.2954857349395752,
-0.08210399001836777,
-0.31384673714637756,
0.3261337876319885,
-0.3647025227546692,
0.009474653750658035,
-0.19128429889678955,
0.49667537212371826,
-0.2640068829059601,
0.23142938315868378,
0.29204484820365906,
-0.05621085315942764,
-0.14121386408805847,
0.53635174036026,
-0.3887326419353485,
-0.24421630799770355,
-0.32175296545028687,
-0.05630325898528099,
0.06926237791776657,
0.13902078568935394,
-0.34667956829071045,
-0.4245181679725647,
-0.06825104355812073,
0.08626271039247513,
0.5672338604927063,
-0.4073892831802368,
-0.1227598562836647,
-1.5160127878189087,
0.29839634895324707,
-0.17737597227096558,
-0.03625623136758804,
-0.055538348853588104,
0.07043357938528061,
0.8902631998062134,
0.4418181777000427,
-0.21166180074214935,
0.06472949683666229,
-0.45617422461509705,
-0.1548318862915039,
-0.0026397183537483215,
-0.1571032702922821,
0.8031608462333679,
0.22516502439975739,
0.32787075638771057,
0.5574022531509399,
-0.12631559371948242,
0.47803568840026855,
-0.1501714587211609,
0.1035391092300415,
-0.2688308358192444,
0.13522189855575562,
0.10393738746643066,
0.086908720433712,
-0.3376588523387909,
-0.3624047338962555,
0.007044150494039059,
0.05592627078294754,
0.06735114008188248,
-0.4994611442089081,
0.5188146829605103,
-0.03527487814426422,
-0.39732179045677185,
0.28961458802223206,
0.8608360290527344,
0.10803757607936859,
0.5821012854576111,
-0.08773769438266754,
0.0185373704880476,
0.4958955645561218,
-0.18036596477031708,
0.03155920282006264,
0.010601868852972984,
-0.8761746883392334,
0.31868502497673035,
0.3101181387901306,
-0.1586291342973709,
0.4677630662918091,
0.38615846633911133,
0.2584233582019806,
-0.14536282420158386,
-0.4832659363746643,
0.20371641218662262,
0.3769872486591339,
-0.301252543926239,
-0.4293762743473053,
-0.2546271085739136,
-0.17538228631019592,
0.10729025304317474,
-0.8931360840797424,
0.124966099858284,
0.13531583547592163,
-0.3063673973083496,
0.18583977222442627,
0.36447176337242126,
-0.33624592423439026,
0.26976388692855835,
-0.05553292855620384,
0.35570043325424194,
-0.17733632028102875,
0.010127975605428219,
0.33688023686408997,
-0.08021703362464905,
-0.3505004942417145,
0.14884181320667267,
-0.0634152963757515,
0.3094863295555115,
0.1794501543045044,
0.23157727718353271,
0.3805885910987854,
-0.5204699039459229,
0.05974278226494789,
0.17721877992153168,
0.5432628989219666,
-0.22230657935142517,
-0.5008381605148315,
0.3836318850517273,
-0.46193385124206543,
0.2906119227409363,
-0.005162184126675129,
0.09675310552120209,
0.08606310933828354,
-0.34495747089385986,
0.728882372379303,
-0.7471867203712463,
0.19118566811084747,
-0.14207927882671356,
-0.10171236842870712,
0.1567748636007309,
0.09214067459106445,
-0.22187204658985138,
0.0740552470088005,
-0.2808118462562561,
-0.7542321085929871,
0.28405049443244934,
-0.658936619758606,
-0.06908749043941498,
-0.01433531567454338,
-0.7246775031089783,
0.09524660557508469,
0.14572343230247498,
0.10603055357933044,
0.26808151602745056,
0.3393734395503998,
-0.2577511668205261,
-0.3034217357635498,
0.3033706843852997,
-0.5621574521064758,
0.03742503374814987,
0.04356467351317406,
0.0924544632434845,
0.20135821402072906,
0.0030550737865269184,
-0.11253572255373001,
0.1513034850358963,
-0.2262924760580063,
-0.20110242068767548,
0.43634769320487976,
0.8696234822273254,
0.37147200107574463,
0.2845849096775055,
-0.46409615874290466,
-0.6293292045593262,
-0.18955375254154205,
0.07452485710382462,
0.3174237906932831,
0.39320409297943115,
0.027001457288861275,
-0.22476977109909058,
0.15229645371437073,
0.2332679182291031,
0.2356853038072586,
-0.2385324090719223,
-0.4432682991027832,
0.34488558769226074,
-0.32958731055259705,
1.216640591621399,
0.1595122218132019,
-0.586348295211792,
0.9108093976974487,
0.10073733329772949,
-0.12395989894866943,
-0.2692263722419739,
-0.04799184948205948,
0.10120765119791031,
-0.1859559714794159,
0.2983420193195343,
0.3298019468784332,
0.02400360070168972,
0.1514042466878891,
-0.2024204432964325,
0.5473985075950623,
0.26080378890037537,
-0.884172260761261,
0.2622978687286377,
-0.07458414137363434,
-0.0001256255927728489,
0.10320334881544113,
0.25681596994400024,
0.04268817603588104,
-0.24604438245296478,
0.4830555021762848,
0.36884722113609314,
-0.2912571430206299,
-0.20960620045661926,
0.47875073552131653,
-0.08853315562009811,
0.5382544994354248,
0.8563892841339111,
-0.47781530022621155,
0.42714664340019226,
-0.5734965205192566,
-0.15943072736263275,
0.18556109070777893,
0.5024111270904541,
0.06799720227718353,
0.05305762588977814,
0.17999765276908875,
0.3544345200061798,
-0.23086299002170563,
0.4308337867259979,
-0.18211226165294647,
0.34066829085350037,
0.3021722733974457,
-0.12536130845546722,
0.8549941778182983,
-0.16042765974998474,
0.17642280459403992,
-0.36547091603279114,
0.7006706595420837,
-0.2848043441772461,
0.3616791367530823,
0.15904900431632996,
0.6385838985443115,
-0.3465502858161926,
-0.15108723938465118,
-0.3440633714199066,
0.05086374282836914,
-0.09352795779705048,
-0.7794491052627563,
1.1616908311843872,
0.30078694224357605,
-0.2734435796737671,
0.13415290415287018,
0.39270102977752686,
0.43010231852531433,
0.19677186012268066,
-0.33118507266044617,
-0.4600418508052826,
-0.6146059632301331,
0.21988356113433838,
0.07250355929136276,
0.571914792060852,
0.44708549976348877,
-0.5190523862838745,
0.14716923236846924,
-0.13746589422225952,
-0.15071234107017517,
0.2749311923980713,
0.06247993931174278,
-0.5739330649375916,
-0.5099815130233765,
0.2608354985713959,
0.8001511693000793,
0.31460580229759216,
-0.13539588451385498,
-0.040278803557157516,
-0.054839275777339935,
0.16064395010471344,
-0.036208730190992355,
-0.02181711606681347,
-0.33778220415115356,
-0.2773864269256592,
0.9020611643791199,
-0.3243667185306549,
-0.7153810858726501,
0.04208481311798096,
0.545803964138031,
-0.3705921173095703,
0.1433088779449463,
0.6329048871994019,
0.10740435868501663,
0.04359589144587517,
0.42984238266944885,
-0.46265938878059387,
0.09111740440130234,
0.06467019021511078,
-0.3168468773365021,
-0.14853250980377197,
0.016747785732150078,
-6.055482387542725,
0.3302163779735565,
-0.18171031773090363,
-0.016720732674002647,
0.02319105714559555,
-0.13493609428405762,
0.5396375060081482,
0.2110137790441513,
-0.03751407191157341,
-0.22199124097824097,
-0.1510065793991089,
0.42923539876937866,
-0.09580251574516296,
0.7438618540763855,
-0.37834176421165466,
0.2899177074432373,
0.0897582545876503,
-0.19308200478553772,
0.10439537465572357,
0.13695357739925385,
-0.25321531295776367,
0.09595169872045517,
-0.20458221435546875,
0.4232715666294098,
0.5014778971672058,
0.047731898725032806,
-1.1125025749206543,
0.018412860110402107,
-0.12109886109828949,
-0.037916626781225204,
-0.2039305418729782,
-0.5818329453468323,
-0.4474167823791504,
0.5795568823814392,
0.31449827551841736,
0.22630248963832855,
0.18617866933345795,
-0.5685220956802368,
-0.015168446116149426,
-0.4340671896934509,
0.24869392812252045,
0.7282990217208862,
-0.13016295433044434,
0.03644905611872673,
0.1505119800567627,
-0.6658255457878113,
-0.3655025064945221,
-0.44863271713256836,
-0.05055098608136177,
0.3714635670185089,
0.023079391568899155,
-0.23876266181468964,
-0.05193864181637764,
0.03883900120854378,
0.4433249235153198,
0.20586077868938446,
-0.4233275055885315,
0.1161704808473587,
-0.5347632765769958,
-0.10785356909036636,
-0.027125319465994835,
0.35363367199897766,
0.24363237619400024,
-0.7663341760635376,
-0.027396883815526962,
-0.297675758600235,
-0.43787071108818054,
0.0187358520925045,
0.6763279438018799,
-0.1671876758337021,
-0.19605320692062378,
0.8700948357582092,
-0.19388651847839355,
-1.0877535343170166,
0.6749612092971802,
-0.24298031628131866,
-0.050276365131139755,
0.0809769555926323,
0.11575546860694885,
-0.39856576919555664,
0.22407011687755585,
-0.25422775745391846,
0.3973511755466461,
0.29555797576904297,
-0.4062531292438507,
-0.4672471880912781,
0.6080266833305359,
-0.049727726727724075,
-0.3296917676925659,
0.36875298619270325,
0.8454751968383789,
-0.025102883577346802,
-0.0440397635102272,
0.13102082908153534,
0.3456577658653259,
0.3721899390220642,
0.29444223642349243,
0.1295357346534729,
0.057277314364910126,
0.4300821125507355,
0.5410692095756531,
-0.47336918115615845,
-0.7121453285217285,
-0.522974967956543,
-0.06696981936693192,
0.07873433083295822,
-0.5829508304595947,
-0.16441993415355682,
0.8499546051025391,
-0.28159716725349426,
-0.3464118540287018,
0.16700150072574615,
0.3300841450691223,
-0.3792259991168976,
0.7619816660881042,
-0.29964980483055115,
-0.18334785103797913,
-0.09071371704339981,
-0.10001323372125626,
-0.2382032871246338,
0.311911404132843,
0.04847046360373497,
-0.5145357847213745,
-0.7948334813117981,
0.1933848112821579,
0.15947553515434265,
-0.07917981594800949,
0.21687714755535126,
-0.4339722692966461,
0.1422574520111084,
0.18700875341892242,
0.23264512419700623,
-0.24890372157096863,
-0.31223174929618835,
0.5629391074180603,
-0.5168471932411194,
-0.5958117246627808,
0.030065950006246567,
-0.02635238878428936,
0.03791395574808121,
-0.07384499162435532,
-0.04574084281921387,
-0.19762590527534485,
-0.07035816460847855,
-0.10721287876367569,
-0.30352580547332764,
0.08575594425201416,
-0.21392729878425598,
-0.21785672008991241,
0.11133627593517303,
0.18957401812076569,
-0.6505958437919617,
0.750384509563446,
0.11207279562950134,
-0.18107984960079193,
-0.32716479897499084,
-0.2177644670009613,
0.2940743863582611,
-0.42298904061317444,
-0.02862115018069744,
0.1321224868297577,
0.0014236533315852284,
-0.9834737181663513,
-0.06193217262625694,
0.6306866407394409,
-0.2910030782222748,
0.4724681079387665,
-0.31848448514938354,
0.2918839752674103,
0.4484955966472626,
0.38452041149139404,
-0.4329838752746582,
0.15104009211063385,
-0.0762997642159462,
0.24706849455833435,
0.495891273021698,
-0.21391038596630096,
-0.08355128020048141,
0.1283959150314331,
-0.19011317193508148,
0.2968094050884247,
0.03855740651488304,
-0.20299533009529114,
0.28714117407798767,
0.5675852298736572,
0.1426120400428772,
-0.11170089244842529,
-0.1375294178724289,
-0.02779792994260788,
0.06518172472715378,
0.13034100830554962,
0.40222835540771484,
0.45076289772987366,
0.6110254526138306,
-0.7046736478805542,
-0.08229118585586548,
0.253174751996994,
0.32295161485671997,
-0.18487437069416046,
0.04025900736451149,
0.04409431293606758,
0.11101245880126953,
-0.1936955451965332,
0.3529452681541443,
1.1033759117126465,
-0.869036078453064,
-0.04751550778746605,
-0.741174578666687,
0.23293562233448029,
-0.521292507648468,
0.20627495646476746,
0.38417893648147583,
-0.3083289861679077,
-0.33788496255874634,
0.1916707307100296,
0.19524650275707245,
-0.15852020680904388,
-0.6203378438949585,
-0.20690026879310608,
0.0353546068072319,
-0.20572227239608765,
-0.5371600985527039,
-0.7036242485046387,
0.12927833199501038,
-0.14638561010360718,
0.20891675353050232,
0.3447740375995636,
-0.3737706243991852,
0.00366228143684566,
0.001663830247707665,
0.34589236974716187,
0.47394952178001404,
0.269692599773407,
0.15012279152870178,
-0.5577645897865295,
-0.5928846001625061,
0.1653459221124649,
-0.1714470088481903,
-0.03526153415441513,
0.3589029014110565,
0.3978355824947357,
0.12405572086572647,
-0.40857306122779846,
-0.3226260542869568,
0.2069796919822693,
0.08765706419944763,
-0.11347340792417526,
-0.8507189750671387,
-0.5382504463195801,
0.2723034620285034,
0.3228137195110321,
-0.3932154178619385,
-0.13435056805610657,
-0.5776534676551819,
0.31855103373527527,
-0.14279328286647797,
0.013794108293950558,
-0.2335413694381714,
0.08050784468650818,
0.24238355457782745,
-0.26225101947784424,
0.3262164890766144,
-0.7026402354240417,
0.02763504907488823,
-0.054542556405067444,
0.27595725655555725,
0.032598309218883514,
-0.5998225808143616,
0.19199073314666748,
-0.15169624984264374,
-0.565208911895752,
-0.0249044056981802,
0.3567477762699127,
0.2262651026248932,
0.10335276275873184,
-0.11374540627002716,
-0.9652089476585388,
-0.18985827267169952,
-0.5051270127296448,
-0.6272744536399841,
-0.17850635945796967,
0.04932281747460365,
0.18818430602550507,
-0.018782388418912888,
0.2638293504714966,
-0.22952967882156372,
0.16432605683803558,
-0.4045914113521576,
-0.8054741621017456,
-0.23380914330482483,
0.0112982839345932,
0.5281389951705933,
-0.08168305456638336,
-0.583099901676178,
-0.30104804039001465,
0.3723370134830475,
-0.04673505946993828,
-0.19820521771907806,
-0.015290512703359127,
-0.16136209666728973,
0.004391778260469437,
-0.052520088851451874,
0.738875687122345,
0.0017256985884159803,
-0.32520246505737305,
-0.25626277923583984,
-0.17006291449069977,
-0.12630601227283478,
-0.16636787354946136,
0.3924857974052429,
0.09573908150196075,
-0.16976101696491241,
0.01577683351933956,
0.21439538896083832,
-0.8001364469528198,
-0.41536664962768555,
-0.12784002721309662,
-0.46417883038520813,
0.23162072896957397,
0.24439404904842377,
0.012512837536633015,
0.4501408338546753,
-0.06830539554357529,
0.4356837272644043,
-0.8070864081382751,
0.3027934730052948,
-0.14868351817131042,
0.6949610710144043,
-0.08560867607593536,
0.23705025017261505,
0.45181193947792053,
0.09755765646696091,
-0.11740631610155106,
0.0014902375405654311,
0.5633507966995239,
-0.25977176427841187,
0.5507469773292542,
-0.36889204382896423,
0.3300437927246094,
-0.13796818256378174,
0.7335304021835327,
0.45348453521728516,
-0.3039436638355255,
-0.10215284675359726,
-0.015648523345589638,
0.14180628955364227,
0.26353177428245544,
0.07527218014001846,
0.05645157769322395,
0.6808586716651917,
0.7402340173721313,
0.012425039894878864,
-0.31335940957069397,
-0.3346686363220215,
-0.1984257698059082,
0.5859006643295288,
0.5342131853103638,
-0.4995470643043518,
-0.6215199828147888,
0.39710599184036255,
-0.3604104220867157,
0.18136748671531677,
-0.09705282002687454,
-0.08578137308359146,
-0.310375452041626,
-0.0494530126452446,
0.34234818816185,
-0.4182420074939728,
0.07718663662672043,
-0.1604902297258377,
0.4269038736820221,
-0.390142023563385,
-0.4610440731048584,
0.14193788170814514,
0.16896238923072815,
0.10787614434957504,
0.7359963655471802,
0.16544164717197418,
0.034563519060611725,
0.9415682554244995,
0.0635019987821579,
-0.16921798884868622,
-0.2942807972431183,
-0.24170447885990143,
-0.1354551613330841,
-0.31069472432136536,
0.32979002594947815,
0.3578891456127167,
-0.19018341600894928,
-0.18305687606334686,
-0.06471217423677444,
-0.3464275002479553,
0.027614478021860123,
0.42654839158058167,
0.013238680548965931,
0.26914846897125244,
-0.4099053144454956,
0.44416043162345886,
-0.13612382113933563,
0.4653017818927765,
-0.44107770919799805,
0.15262733399868011,
-0.16737878322601318,
0.6710577011108398,
-0.3219252824783325,
0.005974987987428904,
-0.5476096868515015,
0.05550578236579895,
-0.36465227603912354,
0.17828905582427979,
0.22457018494606018,
0.36673521995544434,
-0.2570049464702606,
0.0009708981378935277,
-0.05729718133807182,
-0.22118251025676727,
0.6032935976982117,
0.01093518827110529,
-0.35284096002578735,
-0.1860494166612625,
0.23071998357772827,
-0.688231885433197,
0.24234668910503387,
0.11890540271997452,
-0.7807976007461548,
-0.0670488104224205,
-0.010847720317542553,
-0.11329404264688492,
0.48923996090888977,
0.06339648365974426,
-0.5413417816162109,
0.19222013652324677,
-0.6130877733230591,
0.4450448751449585,
-0.5577411651611328,
0.20428143441677094,
0.3049236536026001,
-0.07155454903841019,
0.42181316018104553,
-0.44885924458503723,
-0.14132152497768402,
-0.5286135673522949,
-0.24448443949222565,
-0.1548932045698166,
0.16755416989326477,
0.5695096850395203,
-0.10704782605171204,
0.021476425230503082,
-0.10768626630306244,
-0.011788403615355492,
-0.2286943942308426,
0.0837690606713295,
-0.14039325714111328,
-0.2058740109205246,
0.21196484565734863,
-0.18747803568840027,
-0.03482585772871971,
-0.7003527283668518,
0.17037226259708405,
0.17277143895626068
] |
BACKGROUND Due to demographic changes with an increasing number of older people with chronic illness and multimorbidity palliative care for geriatric patients has become increasingly important. The aim of this study was to explore the perspective of bereaved relatives with regard to their experiences and expectations concerning the delivery of care for older people in the last phase of life. METHODS Qualitative interviews with 12 relatives of deceased older patients (aged 60 years or older). The interviews were recorded, transcribed, coded and analysed using the approach of qualitative content analysis according to Mayring. RESULTS The bereaved relatives perceived that the care for geriatric patients in the last phase of life was inappropriate in various respects. They criticised overtreatment (e.g. skin cancer diagnostic) as well as unmet needs (e.g. treatment of pain, patient centred care, communication). Family doctors were seen as the primary contact persons in the professional health system. CONCLUSIONS From the perspective of bereaved relatives care for older people in the last phase of life has serious deficits. They criticise an inappropriate priority setting and the disregard of palliative care. There is a need for better communication and information exchange regarding the needs and expectations of patients and relatives, and regarding the targets of treatment. Therefore it may be helpful to use advance directives more intensively. Furthermore, it seems to be necessary to strengthen generalist palliative care particularly delivered by family doctors and community nurses. | [
0.013968320563435555,
0.01223752461373806,
-0.01844412088394165,
0.01223425567150116,
0.016697091981768608,
-0.002125980332493782,
0.00943265575915575,
0.005685929674655199,
-0.013806459493935108,
-0.016539260745048523,
0.001126025221310556,
0.011746186763048172,
0.006035860627889633,
0.0033935988321900368,
0.04515257477760315,
-0.002738409675657749,
-0.026379169896245003,
-0.01051950454711914,
0.009093303233385086,
0.001980364555492997,
0.02112603560090065,
0.02277485281229019,
0.010046256706118584,
0.012688586488366127,
0.008290812373161316,
0.007536360062658787,
-0.011987507343292236,
0.009515898302197456,
0.012938814237713814,
-0.005867426283657551,
-0.007615800015628338,
0.010806206613779068,
-0.02410285919904709,
-0.007848836481571198,
0.006476955488324165,
-0.035956136882305145,
0.004359857179224491,
0.014387808740139008,
-0.03468189015984535,
-0.005561718251556158,
0.024341804906725883,
-0.0071235839277505875,
-0.0026081916876137257,
0.018284905701875687,
-0.008378210477530956,
-0.0006653566379100084,
-0.01470363512635231,
0.001380519475787878,
-0.0037246141582727432,
0.011085012927651405,
-0.010996856726706028,
0.003533461596816778,
-0.005787678528577089,
-0.008778970688581467,
-0.006268335040658712,
-0.015221712179481983,
0.022134095430374146,
0.019970519468188286,
-0.009201129898428917,
-0.0021924125030636787,
-0.019225260242819786,
-0.025991063565015793,
0.017447082325816154,
-0.01826428435742855,
-0.036003585904836655,
-0.06656038761138916,
-0.017177972942590714,
-0.005906298290938139,
0.0032039149664342403,
-0.008038058876991272,
-0.001504036015830934,
0.010451480746269226,
-0.011290302500128746,
0.010489671491086483,
0.006357687991112471,
0.0173094030469656,
-0.003268192755058408,
0.0015567122027277946,
0.011714247055351734,
-0.0016187792643904686,
-0.016515467315912247,
0.002367595210671425,
-0.0034653986804187298,
0.02359548956155777,
0.006227306090295315,
0.03103122115135193,
0.010988971218466759,
-0.00046108034439384937,
0.011713304556906223,
0.01630682498216629,
-0.00758761540055275,
-0.025994932278990746,
0.012844512239098549,
-0.0007145875133574009,
-0.033961594104766846,
0.028131457045674324,
-0.004781737923622131,
-0.009904788807034492,
-0.013082291930913925,
0.0024431883357465267,
-0.007135339081287384,
0.003923116251826286,
0.02452544867992401,
0.03134430572390556,
-0.039341241121292114,
0.012783735059201717,
0.001598984468728304,
-0.00887296162545681,
0.015631169080734253,
0.0033891843631863594,
0.0032818035688251257,
0.0029744869098067284,
-0.004369143862277269,
0.013030440546572208,
0.0057030715979635715,
-0.00019400299061089754,
0.023931503295898438,
-0.007504808716475964,
0.008088436909019947,
-0.03965629264712334,
0.020962271839380264,
0.007275948766618967,
-0.005469063762575388,
-0.0013575321063399315,
-0.002919967519119382,
0.007937295362353325,
0.03246501088142395,
0.001553989015519619,
0.013409806415438652,
0.008395826444029808,
-0.009597301483154297,
-0.007336252368986607,
0.026967212557792664,
-0.001963338814675808,
0.012350128963589668,
-0.0067154052667319775,
-0.02652541920542717,
0.012144992128014565,
0.00844063051044941,
-0.0048697879537940025,
-0.0036746812984347343,
0.013085849583148956,
-0.00035904880496673286,
0.003223019652068615,
-0.01843569055199623,
-0.01750943437218666,
0.01208641566336155,
0.0023146821185946465,
0.005863259080797434,
-0.0160631462931633,
0.0006847120821475983,
-0.015607090666890144,
-0.012880513444542885,
-0.027789238840341568,
0.019185509532690048,
-0.010586749762296677,
-0.007836169563233852,
-0.010890458710491657,
-0.00645967572927475,
0.011702345684170723,
0.05676957592368126,
-0.008547134697437286,
-0.004223044030368328,
0.010057144798338413,
0.0076392339542508125,
-0.024209855124354362,
0.011593574658036232,
-0.0011531203053891659,
-0.010790118016302586,
0.007385236211121082,
-0.0005817869678139687,
-0.009200419299304485,
-0.007720861118286848,
0.0023579243570566177,
0.01949036493897438,
-0.00883446540683508,
-0.0034211878664791584,
0.006202876567840576,
0.009177569299936295,
0.06604595482349396,
-0.02523917146027088,
0.02059384435415268,
-0.009487591683864594,
-0.02066965028643608,
0.006101642735302448,
-0.0090619632974267,
0.018490364775061607,
-0.008713090792298317,
-0.0018350319005548954,
0.0095098577439785,
-0.007295834831893444,
0.008610918186604977,
0.007234993390738964,
-0.006853274069726467,
0.008673244155943394,
0.0041564214043319225,
-0.021701619029045105,
0.0096341073513031,
0.009939772076904774,
-0.01070365495979786,
-0.011323768645524979,
-0.02094302698969841,
0.009353789500892162,
-0.03076290339231491,
-0.010848602280020714,
0.012846865691244602,
0.019235806539654732,
-0.0019315872341394424,
0.03044063039124012,
0.008520973846316338,
0.02657487243413925,
0.005391022656112909,
0.0018451802898198366,
-0.01544999796897173,
0.006203143857419491,
-0.003283363301306963,
-0.01703091524541378,
-0.0004051756113767624,
-0.01653345301747322,
-0.016411226242780685,
0.005778315477073193,
0.0060253082774579525,
0.016727274283766747,
-0.0033504622988402843,
0.017798330634832382,
-0.0005056175868958235,
0.017823554575443268,
0.008560995571315289,
0.052377086132764816,
0.013633174821734428,
-0.014640090987086296,
0.0020557919051498175,
-0.004498870112001896,
0.019432123750448227,
0.02270846627652645,
0.04620274156332016,
0.01171620562672615,
-0.027544450014829636,
-0.0012314103078097105,
-0.010882492177188396,
-0.01714952662587166,
-0.009808691218495369,
0.01565011590719223,
-0.013917138800024986,
0.010019262321293354,
-0.0243832990527153,
0.0036593759432435036,
-0.01131310686469078,
0.005854315124452114,
-0.01850387081503868,
0.006748741492629051,
0.007609745021909475,
0.008692780509591103,
-0.009607203304767609,
0.013690212741494179,
-0.004979602061212063,
0.0092401634901762,
-0.02650597132742405,
0.02651129476726055,
0.014962779358029366,
0.01459292508661747,
0.011517852544784546,
-0.0036963338498026133,
-0.0029696146957576275,
0.003889400279149413,
-0.023577211424708366,
0.004507822450250387,
0.00854499451816082,
0.013082990422844887,
-0.022722305729985237,
0.007020456250756979,
-0.010622695088386536,
0.003624327713623643,
-0.08164465427398682,
0.0001307134225498885,
-0.006154222413897514,
0.003381566144526005,
0.008818304166197777,
0.013964992016553879,
0.030902568250894547,
0.015788841992616653,
-0.004142231773585081,
-0.03780750185251236,
0.0037968687247484922,
-0.008285457268357277,
-0.006176723632961512,
0.025969654321670532,
0.014733275398612022,
-0.0000010533258318901062,
0.003820859594270587,
-0.015569141134619713,
-0.0017909074667841196,
0.002743777818977833,
-0.00850030779838562,
0.015858810395002365,
0.012850688770413399,
-0.008027132600545883,
0.005072996020317078,
0.03169459104537964,
0.03496686369180679,
0.006491643842309713,
0.01849346235394478,
0.012029274366796017,
0.00004357704892754555,
-0.025687692686915398,
-0.014285407960414886,
-0.03343895822763443,
0.0049901180900633335,
-0.0032518550287932158,
-0.026247624307870865,
0.026320558041334152,
-0.004328334704041481,
0.015075648203492165,
-0.004209627863019705,
0.009197722189128399,
-0.012621435336768627,
-0.021765127778053284,
-0.005787358153611422,
0.004891177173703909,
0.003094432409852743,
-0.0181878749281168,
0.008698660880327225,
-0.025157669559121132,
0.025404086336493492,
-0.012490861117839813,
0.0053968606516718864,
0.0056503587402403355,
-0.02325369045138359,
-0.007337307557463646,
0.015335175208747387,
-0.0017441362142562866,
-0.008641078136861324,
-0.014740662649273872,
-0.007317120209336281,
-0.020611967891454697,
0.006896395236253738,
0.006223919335752726,
0.014477756805717945,
0.008691092021763325,
0.005171801894903183,
-0.0038361819460988045,
-0.025990433990955353,
0.012506449595093727,
0.025397999212145805,
-0.006608540192246437,
0.00042590778321027756,
-0.01060892827808857,
0.024744335561990738,
-0.0043329885229468346,
-0.02016947790980339,
0.005813668482005596,
0.030007075518369675,
0.018619710579514503,
-0.023569364100694656,
-0.006020670291036367,
0.00015114282723516226,
-0.012743830680847168,
-0.009871849790215492,
-0.010004043579101562,
0.017360452562570572,
0.014550437219440937,
0.012151900678873062,
-0.014530258253216743,
-0.004547919612377882,
0.007379641756415367,
0.009482031688094139,
0.00912120658904314,
0.009986814111471176,
0.00048595620319247246,
0.012662466615438461,
0.006610302720218897,
0.010372928343713284,
0.009547073394060135,
-0.00740737933665514,
-0.005485950969159603,
-0.02435649186372757,
-0.016240086406469345,
-0.0012807110324501991,
0.006221449002623558,
-0.006550949532538652,
-0.021699104458093643,
-0.00014360877685248852,
-0.0102249626070261,
-0.028802406042814255,
-0.027103012427687645,
-0.008598798885941505,
0.031051289290189743,
0.01166675053536892,
0.01615370623767376,
-0.008449025452136993,
0.005319241899996996,
0.07237416505813599,
-0.006460538599640131,
0.013425870798528194,
-0.017624951899051666,
-0.00037624710239470005,
-0.001803495455533266,
-0.0367484875023365,
-0.0004285508766770363,
-0.011503834277391434,
-0.03365485742688179,
0.014128563925623894,
0.07281456887722015,
0.033912912011146545,
-0.0034030918031930923,
-0.007828988134860992,
0.00466580456122756,
-0.002293621189892292,
0.0033948076888918877,
0.01847393624484539,
0.007841100916266441,
0.0136573426425457,
0.024190910160541534,
-0.00016256235539913177,
-0.013618460856378078,
0.012098753824830055,
0.0164826437830925,
-0.043390776962041855,
-0.015007304027676582,
-0.006496083457022905,
0.0054584676399827,
-0.017265040427446365,
0.03243396058678627,
-0.002390200737863779,
-0.014743927866220474,
0.028109464794397354,
0.03090786002576351,
-0.0098029226064682,
0.0033597578294575214,
0.002384366700425744,
0.000127892242744565,
-0.02724088542163372,
-0.008503489196300507,
-0.004300184082239866,
0.010435676202178001,
-0.011521035805344582,
0.011969132348895073,
-0.0257582850754261,
-0.006691593676805496,
-0.012609591707587242,
0.012288684956729412,
-0.008174341171979904,
0.002082766266539693,
0.015118008479475975,
0.008512030355632305,
-0.015031076967716217,
0.00042565492913126945,
0.01561238057911396,
-0.01827138662338257,
-0.01270524226129055,
0.028819944709539413,
-0.021872326731681824,
-0.006760232150554657,
-0.016461290419101715,
-0.03082120418548584,
-0.016722513362765312,
-0.026846257969737053,
0.034452639520168304,
-0.015046175569295883,
0.006955381017178297,
0.01593599282205105,
0.023909516632556915,
0.015018328092992306,
-0.025780633091926575,
-0.00020672776736319065,
-0.003154903883114457,
-0.0076693203300237656,
0.0010641973931342363,
-0.03658316284418106,
-0.006373589858412743,
-0.0012764697894454002,
-0.013498999178409576,
0.019547514617443085,
-0.003275331575423479,
-0.03879430890083313,
0.003467586822807789,
0.009025722742080688,
-0.017174821346998215,
-0.07544209063053131,
-0.021003104746341705,
0.018400020897388458,
-0.017494937404990196,
-0.03235848248004913,
0.0330326147377491,
-0.01239081658422947,
-0.020780233666300774,
-0.007587304338812828,
-0.011056636460125446,
-0.015206712298095226,
-0.009134833700954914,
-0.0018496650736778975,
-0.03465951979160309,
0.015186005271971226,
0.013954389840364456,
-0.01949942857027054,
-0.005806492641568184,
-0.012657822109758854,
-0.008026348426938057,
0.039580803364515305,
0.014736304059624672,
-0.020226530730724335,
0.02044839784502983,
0.00024360395036637783,
-0.08119102567434311,
-0.01860373094677925,
-0.010516943410038948,
-0.0032289940863847733,
-0.021487656980752945,
0.0025150394067168236,
0.012714064680039883,
-0.012950499542057514,
-0.019846584647893906,
-0.015070497058331966,
0.006013501435518265,
-0.007656856905668974,
0.022242704406380653,
0.002747834660112858,
0.008635789155960083,
-0.0001360525202471763,
0.006719750352203846,
0.02221401035785675,
-0.0035394392907619476,
0.0037532621063292027,
-0.014150917530059814,
0.02293832041323185,
-0.00414153840392828,
0.026860900223255157,
-0.0003465648042038083,
-0.01745941862463951,
-0.010729467496275902,
0.00870717316865921,
-0.022439416497945786,
-0.023575831204652786,
0.02837914228439331,
-0.018767518922686577,
-0.009368371218442917,
-0.011081529781222343,
-0.00783182680606842,
-0.007508594077080488,
0.03355052322149277,
-0.005746166221797466,
-0.04115763306617737,
0.012619838118553162,
-0.004097341559827328,
0.0007132692262530327,
0.016027867794036865,
-0.0036235512234270573,
0.008016162551939487,
0.00444890046492219,
0.007251815404742956,
-0.00612305011600256,
0.0015857407124713063,
0.02877122350037098,
0.021935440599918365,
-0.011326349340379238,
0.001082349568605423,
0.0005844694096595049,
-0.025334982201457024,
-0.004731537774205208,
-0.002276284620165825,
0.013035905547440052,
0.017654109746217728,
0.013547554612159729,
0.002337018959224224,
-0.001859959214925766,
-0.032349593937397,
0.07102726399898529,
-0.034076470881700516,
0.0034246479626744986,
-0.014513176865875721,
-0.012979093007743359,
0.0009067199425771832,
-0.011149628087878227,
-0.017326708883047104,
0.009536677971482277,
0.00198510754853487,
0.01510412897914648,
-0.007307735271751881,
0.0020723422057926655,
0.009230442345142365,
-0.0007671010680496693,
-0.022127268835902214,
0.008922111243009567,
0.019855376332998276,
-0.022430453449487686,
-0.018838627263903618,
-0.01426546648144722,
0.021872784942388535,
-0.025199415162205696,
0.008983737789094448,
0.010377814993262291,
-0.0012663957895711064,
0.0183236263692379,
0.01016954705119133,
-0.0005513561191037297,
0.00970897264778614,
-0.031640805304050446,
-0.016925426200032234,
0.0009661694639362395,
0.0031131631694734097,
0.034609705209732056,
0.005881882272660732,
0.0012665675021708012,
0.0012979574967175722,
0.007728478871285915,
-0.02269921638071537,
0.010001936927437782,
-0.010487876832485199,
0.008104507811367512,
-0.010975678451359272,
0.01161193661391735,
0.00042669347021728754,
0.007302603684365749,
-0.002226075157523155,
0.004880846943706274,
0.017513897269964218,
0.013300413265824318,
0.0008530435152351856,
0.02536068856716156,
-0.033618852496147156,
-0.010919319465756416,
-0.02850537747144699,
-0.01528282929211855,
0.017773369327187538,
0.00712426146492362,
-0.019066058099269867,
-0.012832146137952805,
-0.00397562887519598,
0.008600413799285889,
-0.014154080301523209,
-0.011203545145690441,
0.016630249097943306,
0.011065333150327206,
-0.014231894165277481,
-0.015726078301668167,
0.013565219938755035,
-0.02536766231060028,
0.009144812822341919,
0.008812831714749336,
-0.003547052387148142,
0.0068600294180214405,
-0.01205967552959919,
0.007796045858412981,
0.009574498981237411,
0.020390771329402924,
0.02242153510451317,
-0.010685241781175137,
0.015362076461315155,
-0.009451300837099552,
-0.02028096839785576,
-0.020413484424352646,
-0.0027389652095735073,
0.020400520414114,
0.024136168882250786,
-0.010324966162443161,
0.004302434157580137,
0.016221841797232628,
-0.0024967631325125694,
-0.001043190830387175,
0.003670475445687771,
0.006027579307556152,
0.035709891468286514,
-0.00561926607042551,
-0.0001524398976471275,
0.009539610706269741,
-0.004147043917328119,
0.0011822511442005634,
0.026399338617920876,
-0.0276071447879076,
-0.005203669425100088,
-0.0005529902409762144,
-0.000596269906964153,
0.00023163226433098316,
0.023965580388903618,
-0.0037744666915386915,
-0.006718532182276249,
0.0029852143488824368,
-0.01434204913675785,
0.028990384191274643,
0.01248396560549736,
0.0003085765056312084,
0.03194465860724449,
0.012407343834638596,
-0.008641826920211315,
0.010935152880847454,
-0.011451445519924164,
-0.009381502866744995,
-0.0007983542745932937,
-0.030196530744433403,
0.028623633086681366,
0.0010450617410242558,
0.024065766483545303,
-0.0002351209695916623,
0.03498180955648422,
0.01157207041978836,
-0.01803191751241684,
0.014579979702830315,
-0.0004252851940691471,
-0.008951414376497269,
0.006443020887672901,
-0.0022330766078084707,
0.009543944150209427,
0.012630240060389042,
0.0012518673902377486,
-0.019930168986320496,
-0.011809900403022766,
0.030884336680173874,
0.004025191068649292,
0.008558801375329494,
0.007010008208453655,
0.008837569504976273,
-0.008317245170474052,
0.001107694348320365,
0.03384348005056381,
0.0191570483148098,
-0.009598275646567345,
-0.008192234672605991,
0.0023859692737460136,
-0.013436522334814072,
-0.0014485298888757825,
0.0019085556268692017,
0.0009411950595676899,
-0.001454054843634367,
0.0029201831202954054,
0.007104633376002312,
-0.01144667062908411,
-0.011745063588023186,
-0.008432085625827312,
-0.015136711299419403,
-0.0033324130345135927,
-0.015152480453252792,
-0.002234376035630703,
0.004888176918029785,
0.00889894925057888,
0.004515867680311203,
0.01067651528865099,
-0.011812454089522362,
-0.01542014628648758,
-0.010789885185658932,
0.0023260219022631645,
-0.017803508788347244,
0.0018792025512084365,
0.004745934158563614,
0.023415585979819298,
-0.0011079083196818829,
0.030452784150838852,
0.003493097610771656,
0.005639055278152227,
0.004820483736693859,
-0.017182521522045135,
-0.010515611618757248,
0.0044721569865942,
-0.004145992454141378,
0.0077476948499679565,
0.01102893240749836,
0.03636429086327553,
-0.001468154601752758,
-0.0011790553107857704,
-0.02840343862771988,
0.013970224186778069,
-0.008726397529244423,
0.011072473600506783,
0.01620524376630783,
-0.02959260530769825,
-0.00802094116806984,
0.011345410719513893,
-0.005961800459772348,
-0.010361461900174618
] | [
0.4883370101451874,
0.006827362813055515,
-0.12040062248706818,
-0.015147725120186806,
0.4312856197357178,
0.7954737544059753,
0.4367043673992157,
-0.07429759204387665,
-0.3226315975189209,
-0.36070188879966736,
0.19203899800777435,
0.4614832103252411,
0.24626286327838898,
-0.02091200090944767,
-0.5680000185966492,
0.48282989859580994,
0.573085367679596,
-0.008997240103781223,
-0.3458634614944458,
-0.7447716593742371,
-0.49656328558921814,
-0.4343535006046295,
0.28721579909324646,
-0.03848257288336754,
-0.03284577280282974,
0.19571234285831451,
0.32672062516212463,
0.05372243747115135,
-0.16218294203281403,
0.008779075928032398,
-0.5107583999633789,
0.37096214294433594,
-0.0920633003115654,
-0.13209989666938782,
0.016574734821915627,
-0.04473873972892761,
0.2870033085346222,
-0.021779656410217285,
0.1680097132921219,
-0.30022233724594116,
0.002394734648987651,
-0.0074813636019825935,
-0.14956577122211456,
0.5472862720489502,
-0.39436835050582886,
-0.2939663529396057,
-1.15837562084198,
0.3301762044429779,
-0.32672014832496643,
-0.21424701809883118,
0.3784213960170746,
0.3019498586654663,
0.6752812266349792,
0.13597124814987183,
-0.0535188652575016,
0.295503705739975,
-0.16782231628894806,
-0.15842142701148987,
0.3177029490470886,
-0.2277139276266098,
-0.07323798537254333,
-0.0016056676395237446,
0.304639607667923,
-0.0873214602470398,
0.04863952472805977,
0.26350894570350647,
0.041346002370119095,
-0.04973023012280464,
0.24296972155570984,
-0.16661284863948822,
-0.22910259664058685,
-0.005309666972607374,
-0.24846096336841583,
0.027344075962901115,
-0.35756736993789673,
0.4779883623123169,
0.032815735787153244,
-0.047678299248218536,
0.43961846828460693,
-0.33696240186691284,
-0.1809564232826233,
-0.4814364016056061,
0.08640583604574203,
-0.3796379268169403,
0.3764277994632721,
0.18394118547439575,
0.25555524230003357,
0.1372777372598648,
-0.07534053176641464,
-0.3380068242549896,
-0.1435806155204773,
-0.6060527563095093,
0.15653541684150696,
1.0054094791412354,
0.018395837396383286,
0.5281199216842651,
0.3884127140045166,
-0.06072236970067024,
0.5229307413101196,
0.1851702630519867,
-0.13145864009857178,
0.050655122846364975,
0.16336534917354584,
-0.17388595640659332,
-0.43565285205841064,
-0.27346715331077576,
0.20616360008716583,
-0.04991152510046959,
-0.9581162929534912,
0.14915402233600616,
-0.6483564972877502,
0.3251919448375702,
-0.13170015811920166,
-0.19691869616508484,
-0.3449799120426178,
-0.14181336760520935,
0.10258542746305466,
-0.27815142273902893,
-0.13800279796123505,
0.37713563442230225,
-0.37075573205947876,
0.589088499546051,
-0.18058478832244873,
0.23039570450782776,
-0.18436719477176666,
0.15608060359954834,
0.5285940170288086,
0.4821307063102722,
-0.10419364273548126,
0.2782292366027832,
0.2836245000362396,
0.34857192635536194,
-0.47453129291534424,
0.3020688593387604,
0.28251731395721436,
-0.4124981760978699,
0.16811220347881317,
0.40285828709602356,
0.4000076651573181,
0.2590225040912628,
-0.09263771772384644,
-0.40742191672325134,
0.05730981007218361,
-0.12202800810337067,
0.16694121062755585,
-0.6496004462242126,
-0.20096434652805328,
-0.13807708024978638,
-0.034016091376543045,
-0.05221040919423103,
0.4794851541519165,
-0.07519076019525528,
-0.18109239637851715,
-0.5517616868019104,
-0.26415011286735535,
0.4743509888648987,
-0.21272507309913635,
-0.6107586026191711,
-0.24520689249038696,
-0.03950142115354538,
0.3326756954193115,
0.4270683228969574,
-0.2966957092285156,
0.18885956704616547,
0.6973573565483093,
-0.08267232775688171,
-0.1816549450159073,
-0.019604729488492012,
-0.13428018987178802,
0.5889086127281189,
-0.13452576100826263,
0.010139494203031063,
-0.4611412286758423,
-0.7144074440002441,
-0.04204969480633736,
0.380644828081131,
0.3380142152309418,
0.01699979417026043,
0.046431634575128555,
-0.2201213538646698,
-0.5775099396705627,
0.31139642000198364,
0.04701758176088333,
-0.4620668292045593,
-0.025898592546582222,
0.09469838440418243,
0.2969159185886383,
0.2146960347890854,
0.09976253658533096,
-0.21466366946697235,
-0.4871387779712677,
-0.4691463112831116,
1.0014177560806274,
-0.7000224590301514,
1.385941505432129,
-0.7727580666542053,
0.20687595009803772,
1.0961651802062988,
0.17887571454048157,
0.09695360064506531,
0.34909212589263916,
-0.36520665884017944,
0.27859941124916077,
0.05616625398397446,
-0.3452802896499634,
0.08128180354833603,
0.14228321611881256,
-0.16535015404224396,
-0.18656642735004425,
-0.0006698336219415069,
0.49905815720558167,
0.05429864302277565,
-0.5488773584365845,
0.09601254761219025,
-0.11139063537120819,
0.11110270023345947,
-0.1609954833984375,
0.24114036560058594,
0.12017706781625748,
-0.028406787663698196,
0.565703272819519,
-0.2699736952781677,
0.2835542857646942,
0.17995046079158783,
-0.07858321815729141,
0.304506778717041,
0.23174752295017242,
-0.24494151771068573,
0.6991025805473328,
-0.7125489711761475,
0.31402215361595154,
0.5510221719741821,
0.01866603083908558,
-0.6058430671691895,
-0.0055783879943192005,
0.0681002140045166,
-0.12794512510299683,
-0.01930265687406063,
0.03911076858639717,
0.043833598494529724,
-0.09998652338981628,
0.09810835868120193,
-0.7185174822807312,
-0.021279845386743546,
0.042737044394016266,
-0.3694540560245514,
-0.8785955309867859,
0.3017256557941437,
-0.7648215293884277,
0.20084214210510254,
0.005488793831318617,
0.2826663553714752,
-0.17064519226551056,
-0.20177976787090302,
-0.2935175597667694,
0.07783559709787369,
-0.1293354481458664,
-0.6085482835769653,
0.16510127484798431,
-0.2385658472776413,
-0.05052216723561287,
0.34158778190612793,
0.37732553482055664,
0.10501489043235779,
0.1128302812576294,
-0.628894031047821,
-0.5667694211006165,
-0.7338125705718994,
0.9983816742897034,
0.40577271580696106,
0.44540444016456604,
0.10355526953935623,
-0.40325719118118286,
0.27322301268577576,
0.05438744276762009,
-0.7052856087684631,
-0.08480237424373627,
0.547646701335907,
-0.5069335699081421,
-0.5334821939468384,
0.23587903380393982,
0.5684141516685486,
0.5959813594818115,
-0.16984334588050842,
-0.06487037241458893,
-0.3708396255970001,
-0.08927187323570251,
0.015082241967320442,
-0.23661310970783234,
0.2971677780151367,
0.027782652527093887,
0.5876227021217346,
-0.11418195813894272,
-0.5574660301208496,
0.7003246545791626,
0.742999792098999,
-0.09857529401779175,
0.37167200446128845,
0.6316298246383667,
0.09510741382837296,
-0.07762251049280167,
0.2427985668182373,
0.26768073439598083,
-0.24531491100788116,
-0.22675742208957672,
0.1268128901720047,
-0.651176929473877,
-0.21941283345222473,
-6.083262920379639,
0.2944433093070984,
-0.3476298749446869,
-0.673941969871521,
-0.15709711611270905,
0.19455201923847198,
1.0360606908798218,
-0.1017790287733078,
0.1763315051794052,
0.1392282247543335,
0.24294719099998474,
0.3442632853984833,
0.44288086891174316,
0.6453057527542114,
-0.017002373933792114,
0.007750466465950012,
0.12382204085588455,
0.08879849314689636,
0.3429901599884033,
0.3993337154388428,
0.061578113585710526,
-0.18986111879348755,
-0.08211851119995117,
0.5052529573440552,
0.31927695870399475,
0.3588431179523468,
-0.6588211059570312,
0.3062112033367157,
-0.13456255197525024,
-0.16547466814517975,
0.3409896492958069,
-0.8230006694793701,
-0.14127306640148163,
-0.04972689598798752,
0.1549890786409378,
0.2512761950492859,
0.11399327218532562,
0.047119516879320145,
0.17542079091072083,
-0.4921347498893738,
-0.15515626966953278,
0.25216931104660034,
0.008717672899365425,
-0.05350296571850777,
0.18553529679775238,
0.29663634300231934,
-0.016345717012882233,
-0.29723337292671204,
-0.09360571950674057,
0.9008159637451172,
0.21991649270057678,
0.06358526647090912,
-0.0278366357088089,
0.1334187239408493,
0.25546348094940186,
0.0435589998960495,
0.13794001936912537,
0.025623837485909462,
-0.26634731888771057,
0.3256981074810028,
0.2854572534561157,
0.008380490355193615,
0.10491770505905151,
-0.6613702178001404,
-0.39592811465263367,
0.033053360879421234,
-1.1963659524917603,
-0.5314326882362366,
0.1612904816865921,
-0.21667863428592682,
-0.18891724944114685,
-0.24799516797065735,
0.23233385384082794,
-0.5415163040161133,
-0.17079490423202515,
-0.3621770143508911,
0.05808808282017708,
0.1551980972290039,
0.06963630020618439,
-0.26242655515670776,
0.20580269396305084,
-0.06401760876178741,
0.3288642168045044,
-0.18527686595916748,
0.19229774177074432,
0.21437962353229523,
-0.32111766934394836,
0.007812032010406256,
-0.3650597333908081,
-0.016152100637555122,
0.5813267230987549,
-0.5233209133148193,
-0.19687305390834808,
0.21427777409553528,
0.587848961353302,
1.0892945528030396,
0.40780773758888245,
-0.004304472357034683,
0.3312762677669525,
-0.16652819514274597,
0.5353795886039734,
-0.18892882764339447,
-0.2011827677488327,
-0.6621688008308411,
0.004013816826045513,
-0.3545434772968292,
-0.6477808356285095,
0.09193235635757446,
0.6033204197883606,
-0.620387852191925,
0.21052256226539612,
-0.19572411477565765,
-0.2832431197166443,
-0.4499128758907318,
0.589221179485321,
-0.4367881417274475,
-0.0337890088558197,
0.08366274833679199,
0.4949142038822174,
-0.242845356464386,
0.2296396940946579,
0.056575626134872437,
-0.06085307151079178,
0.3662070631980896,
-0.39717864990234375,
-0.5248560309410095,
0.11154461652040482,
0.46311676502227783,
-1.216625452041626,
0.25670671463012695,
-0.0053484560921788216,
0.16402113437652588,
-0.18092849850654602,
-0.057281527668237686,
0.10472089797258377,
-0.31978803873062134,
-0.29451268911361694,
-0.07728609442710876,
0.5430809855461121,
0.2329491227865219,
-0.03882468119263649,
-0.341045081615448,
-0.302325576543808,
0.3625298738479614,
0.8440076112747192,
-0.3810407519340515,
-0.26608946919441223,
-0.21519242227077484,
-0.09890082478523254,
0.01904444210231304,
0.034557998180389404,
-0.08334897458553314,
0.3585350215435028,
-0.06298484653234482,
-0.5714879631996155,
-0.1321718543767929,
-0.038388606160879135,
-0.2774200439453125,
-0.37686026096343994,
-0.27531734108924866,
0.41065263748168945,
-0.14665523171424866,
-1.1445964574813843,
-0.1873580515384674,
0.11046958714723587,
-0.5349474549293518,
-0.13721568882465363,
-0.36624976992607117,
0.05479979142546654,
0.2817954421043396,
-0.048180148005485535,
-0.44219040870666504,
0.10954099893569946,
-0.08362028747797012,
0.3656563460826874,
-0.09536398947238922,
-0.17956200242042542,
0.316735178232193,
-0.3174786865711212,
0.13136456906795502,
0.06768893450498581,
-0.057609621435403824,
-0.5546485781669617,
0.18939310312271118,
0.8798874020576477,
0.9338796138763428,
0.07508902996778488,
-0.07804545015096664,
-0.6431799530982971,
-0.28435835242271423,
0.3682780861854553,
-0.2387390285730362,
0.5486574769020081,
0.2585465908050537,
-0.3188823163509369,
-0.1949036419391632,
0.2053363174200058,
0.1880464404821396,
-0.18264268338680267,
0.0697019025683403,
-0.11139015853404999,
0.3022057116031647,
-0.21138493716716766,
0.4578978419303894,
0.5399307608604431,
-0.5693423748016357,
-0.045333344489336014,
-0.45046094059944153,
-0.5812615752220154,
-0.008063728921115398,
-0.09842081367969513,
-0.15339110791683197,
-0.6845303773880005,
0.24029996991157532,
-0.5250583291053772,
0.0447312630712986,
0.1527467966079712,
-0.44568827748298645,
-0.3287630081176758,
0.3235350549221039,
0.6446042656898499,
-0.24286851286888123,
-0.243337482213974,
0.25842657685279846,
-0.3041001856327057,
0.020371291786432266,
0.6122665405273438,
-0.6276984810829163,
-0.24806082248687744,
0.1743716150522232,
-0.6159581542015076,
0.20418992638587952,
0.4594377875328064,
0.05292615294456482,
-0.9605742692947388,
0.02377176098525524,
-0.16161498427391052,
0.12288667261600494,
0.43742766976356506,
0.6481645703315735,
0.25146815180778503,
0.3411194682121277,
0.043512698262929916,
-0.7751179933547974,
-0.03160385414958,
0.222689688205719,
0.3918057680130005,
-0.3274554908275604,
-0.11913776397705078,
0.22841405868530273,
0.4730222821235657,
-0.3489094376564026,
0.06279876828193665,
-0.3197014033794403,
0.0666288435459137,
-0.010742275975644588,
-0.28537875413894653,
-0.45044443011283875,
0.16080081462860107,
0.384622722864151,
0.06986517459154129,
-1.2188453674316406,
-0.13061554729938507,
-0.3410276174545288,
0.40703245997428894,
-0.002687817206606269,
0.1208760216832161,
0.01386392954736948,
0.0961761325597763,
-0.42640548944473267,
-0.07010860741138458,
0.02660883218050003,
0.5038895606994629,
0.20921330153942108,
0.1892988383769989,
-0.01532512716948986,
-0.471828818321228,
0.4234304130077362,
-0.008710826747119427,
-0.004796503111720085,
-0.49339932203292847,
-0.4974629580974579,
-0.3232381045818329,
-0.22858858108520508,
-0.08736792206764221,
-0.2978283762931824,
0.5519004464149475,
-0.024377701804041862,
-0.22960080206394196,
-0.48068058490753174,
-0.14723525941371918,
-0.24153189361095428,
-0.33392333984375,
0.057657770812511444,
0.12147842347621918,
0.23065203428268433,
0.15206414461135864,
0.4184496998786926,
0.6829785108566284,
-0.19254650175571442,
0.005378761328756809,
0.7197197079658508,
0.03344874829053879,
-0.46180468797683716,
0.6277855038642883,
0.23945261538028717,
0.20738646388053894,
-0.2514391243457794,
0.01147376000881195,
0.16988539695739746,
0.13072937726974487,
0.21368861198425293,
0.28151199221611023,
0.6518498659133911,
-0.21921277046203613,
-0.14799989759922028,
-0.22748948633670807,
-0.5569409728050232,
0.7741811871528625,
0.06443960219621658,
0.08042321354150772,
0.6123452186584473,
0.8776974081993103,
-0.0324116088449955,
-0.08367564529180527,
0.5999383926391602,
-0.1164417490363121,
0.4121690094470978,
-0.0034174234606325626,
-0.12960629165172577,
0.4492114782333374,
1.1751583814620972,
0.04187862575054169,
0.2338334619998932,
-0.04317491129040718,
0.41408655047416687,
-0.10465274751186371,
-0.4181981384754181,
0.08447851240634918,
-0.0010840465547516942,
0.755961537361145,
-0.009967831894755363,
0.2191053032875061,
-0.1804630160331726,
0.18310320377349854,
0.526265561580658,
0.03297731652855873,
0.11420206725597382,
0.045760560780763626,
0.1443307250738144,
0.04925111308693886,
0.012006278149783611,
-0.0707150548696518,
-0.4073311388492584,
-0.09763171523809433,
0.2948198616504669,
-0.09312468022108078,
-0.0325281023979187,
-0.7869271039962769,
0.18200653791427612,
0.10610108077526093,
0.046747878193855286,
-0.16535411775112152,
0.11872266232967377,
-0.12951573729515076,
-0.03862748295068741,
0.23402801156044006,
0.442064106464386,
0.18893124163150787,
-0.3291439414024353,
-0.317647248506546,
-0.15018750727176666,
-0.36759066581726074,
-0.04431749880313873,
0.07594171911478043,
-0.863937497138977,
0.3506114184856415,
-0.23603598773479462,
0.1338721215724945,
0.6649625301361084,
-0.0023408918641507626,
0.014731687493622303,
0.03556163236498833,
-0.1558789610862732,
0.1788174957036972,
-0.2689047157764435,
-0.11778931319713593,
0.21456587314605713,
0.23738877475261688,
-0.020289964973926544,
0.2236163467168808,
-0.5838608741760254,
0.3242061734199524,
0.5433982610702515,
-0.5607891082763672,
-0.02004968374967575,
-0.1537557691335678,
0.4053708612918854,
0.3579304814338684,
0.06591501086950302,
-0.2938738763332367,
0.13207274675369263,
-0.12532389163970947,
0.3462311923503876,
-0.19512225687503815,
0.003263561986386776,
-0.6170231699943542,
-0.3651474416255951,
-0.5881639122962952,
-0.04229648783802986,
0.3712780773639679,
-0.06589826941490173,
-0.3727743327617645,
-0.17073313891887665,
-0.1814393252134323,
0.33849474787712097,
0.34973087906837463,
0.23655827343463898,
-0.09117612987756729,
-0.20160943269729614,
-0.0356266126036644,
-0.5289424657821655,
0.5437659025192261,
-0.3842042088508606,
-0.2890093922615051,
-0.17474384605884552,
-0.010725272819399834,
0.44289901852607727,
-0.042143773287534714,
0.3462499976158142,
-0.12970541417598724,
-0.382915198802948,
-0.40716686844825745,
0.4553019404411316,
-0.2995648980140686,
0.4955517649650574,
0.36986657977104187,
0.16470523178577423,
0.2748136520385742,
-0.3021589517593384,
-0.38874635100364685,
-0.6994696855545044,
0.6321814656257629,
0.48910239338874817,
-0.13837361335754395,
0.5409117937088013,
-0.05299080163240433,
-0.15862226486206055,
-1.1237601041793823,
0.1571711152791977,
-0.5344835519790649,
-0.6199834942817688,
0.10874830931425095,
-0.04063945263624191,
-0.4453464150428772,
-0.4207051396369934,
-0.2803557515144348,
-0.49789926409721375,
-0.34811410307884216,
-0.7209356427192688
] |
as compared with 103 (8.2 percent) in the control group; the Kaplan-Meier estimates of the likelihood of freedom from deep-vein thrombosis or pulmonary embolism at 90 days were 94.1 percent (95 percent confidence interval, 92.5 to 95.4 percent) and 90.6 percent (95 percent confidence interval, 88.7 to 92.2 percent), respectively (P 0.001). The computer alert reduced the risk of deep-vein thrombosis or pulmonary embolism at 90 days by 41 percent (hazard ratio, 0.59; 95 percent confidence interval, 0.43 to 0.81; P 0.001). CONCLUSIONS The institution of a computer-alert program increased physicians’ use of prophylaxis and markedly reduced the rates of deep-vein thrombosis and pulmonary embolism among hospitalized patients at risk. Editorial Comment: Most hospitals have adopted electronic systems to alert physicians of drug interactions or possible substitutions, as well as other measures designed to improve the quality of care and decrease expenses. This approach was taken one step further by these authors, who evaluated whether notifying physicians that their patients were at increased risk for venous thromboembolism would decrease the incidence of deep vein thrombosis or pulmonary embolism. The premise was that simply notifying the physician would increase the use of appropriate prophylactic measures. Major surgery (defined as anything requiring general anesthesia), cancer and age greater than 75 years were included among the risk factors, each of which frequently applies to a urology population. In fact, more than 13% of the patients in the intervention group had a known diagnosis of a genitourinary cancer. The computer alert decreased the risk of deep vein thrombosis or pulmonary embolism by 41%. There are 2 lessons urologists can learn from this study. First, many urology patients are at increased risk for venous thromboembolism and appropriate prophylaxis should be used. In addition, although computer alert systems may seem intrusive at times, clinicians can expect to see more and more of them if there is further documentation that they improve the quality of care. | [
0.015584331005811691,
0.013950279913842678,
-0.022468429058790207,
0.016414260491728783,
-0.006905518472194672,
-0.012697381898760796,
0.008885284885764122,
-0.01185566931962967,
-0.008954997174441814,
-0.016627617180347443,
-0.002917519072070718,
0.019443968310952187,
0.0006118665914982557,
0.015003394335508347,
0.007249961607158184,
0.004165477119386196,
-0.01044398918747902,
0.008399223908782005,
0.006101627834141254,
-0.01802307553589344,
-0.00003127590753138065,
0.013684073463082314,
0.008783851750195026,
-0.012394472025334835,
-0.03730538487434387,
0.0018076731357723475,
-0.00009973067790269852,
0.007697150111198425,
0.029511693865060806,
0.0022760736756026745,
-0.0013422917108982801,
0.015783118084073067,
0.003867705352604389,
-0.013706045225262642,
0.029545726254582405,
-0.013963893987238407,
0.0034937565214931965,
-0.002005930058658123,
-0.00004180986434221268,
-0.004603662062436342,
-0.004382584244012833,
-0.014543355442583561,
0.009394795633852482,
-0.009699666872620583,
-0.004098189529031515,
-0.025328030809760094,
-0.008334597572684288,
0.007015818729996681,
-0.0005571611691266298,
0.00989462248980999,
-0.005373971536755562,
-0.008627156727015972,
-0.020300712436437607,
0.0021226275712251663,
-0.005348543636500835,
-0.01731302961707115,
0.01788933016359806,
0.007995786145329475,
-0.021350009366869926,
-0.006204640958458185,
-0.0019383477047085762,
0.012059043161571026,
0.014602248556911945,
-0.032238028943538666,
-0.025771675631403923,
-0.06749670207500458,
0.02082555741071701,
0.005848241969943047,
-0.0012452751398086548,
0.007187759503722191,
0.011122445575892925,
0.011363931000232697,
0.007792189717292786,
0.019341954961419106,
0.006770152598619461,
-0.01365335751324892,
-0.0027168269734829664,
0.023535385727882385,
0.01906086876988411,
-0.01668715476989746,
0.001754134427756071,
-0.0004272949881851673,
0.010482382960617542,
0.0025338600389659405,
-0.004511483479291201,
0.02292701229453087,
-0.009909383952617645,
0.017563777044415474,
-0.0014037378132343292,
-0.033757440745830536,
-0.0006432879017665982,
0.013756468892097473,
0.014432515949010849,
-0.021984180435538292,
0.002997464733198285,
-0.0006192957516759634,
0.011492466554045677,
0.015003088861703873,
-0.005160678643733263,
0.003008525585755706,
-0.008326373063027859,
0.01519116759300232,
0.014932477846741676,
-0.0019719484262168407,
-0.01325876172631979,
0.007049143314361572,
-0.011048763990402222,
-0.0033842362463474274,
0.00930386409163475,
0.003772614523768425,
0.014466753229498863,
0.023956000804901123,
0.01951421983540058,
0.016820216551423073,
-0.010618224740028381,
0.000551935750991106,
0.02576291188597679,
0.015472719445824623,
0.003079633926972747,
-0.005796159617602825,
0.030259279534220695,
0.01019539125263691,
-0.0062712132930755615,
0.018785547465085983,
0.002013350836932659,
-0.01755511201918125,
0.011151963844895363,
-0.007555598393082619,
0.009898493066430092,
-0.006706058979034424,
-0.0027694290038198233,
0.009687243029475212,
-0.02141132764518261,
0.02490207925438881,
0.023170311003923416,
0.01032990776002407,
-0.00411733565852046,
-0.009874208830296993,
-0.019664347171783447,
-0.011880384758114815,
0.003324788063764572,
0.012070408090949059,
-0.00835278071463108,
0.014805320650339127,
-0.004155073314905167,
0.0013460825430229306,
-0.016845975071191788,
0.00014999485574662685,
0.0012851241044700146,
-0.02933432161808014,
-0.0025926048401743174,
-0.01334991492331028,
0.004210414364933968,
-0.018027810379862785,
-0.009459402412176132,
-0.0012487743515521288,
0.003083143150433898,
0.0042415703646838665,
0.012609099969267845,
-0.003719478379935026,
-0.002936998847872019,
0.0025373827666044235,
-0.015566191636025906,
0.007168221287429333,
-0.010407432913780212,
-0.005957958288490772,
-0.018450282514095306,
0.010604985058307648,
-0.024792155250906944,
0.0042481329292058945,
0.0033882830757647753,
-0.004125241190195084,
0.012718630954623222,
0.015428860671818256,
0.01595892198383808,
-0.014396017417311668,
0.03934567794203758,
0.007831643335521221,
-0.00903262011706829,
0.06716657429933548,
0.0011441094102337956,
-0.01128062978386879,
-0.004393390845507383,
0.014195901341736317,
0.013677260838449001,
-0.016941595822572708,
0.011564821936190128,
-0.00516353826969862,
-0.007953522726893425,
-0.014453612267971039,
0.030957238748669624,
0.012524518184363842,
0.010128317400813103,
0.00419797096401453,
-0.006377477198839188,
0.003866230370476842,
-0.0006532790139317513,
0.00158033799380064,
-0.012895742431282997,
0.00006838282570242882,
0.025290653109550476,
-0.0032528273295611143,
-0.0123023996129632,
-0.003067693207412958,
-0.0010623966809362173,
0.02440694347023964,
-0.003020865609869361,
0.031958624720573425,
-0.0029363674111664295,
0.013534331694245338,
0.011648806743323803,
-0.005890660919249058,
0.006947372108697891,
0.000025494955480098724,
-0.033443551510572433,
-0.005440291948616505,
-0.010364516638219357,
0.022508876398205757,
-0.005868758074939251,
-0.014255128800868988,
0.008122134022414684,
0.010546596720814705,
0.017285265028476715,
0.027606191113591194,
0.01917986199259758,
-0.005957545712590218,
-0.003807902568951249,
0.00729448813945055,
0.004107177257537842,
0.008867310360074043,
-0.019088679924607277,
-0.02216549776494503,
-0.010179469361901283,
-0.01100119948387146,
-0.0006802799180150032,
0.014672170393168926,
0.00915290042757988,
-0.025737468153238297,
0.018530935049057007,
-0.01763518899679184,
-0.013482240028679371,
-0.008186102844774723,
0.0008281245827674866,
0.0135418102145195,
-0.006513792090117931,
0.005840446799993515,
-0.0077931806445121765,
-0.0060470569878816605,
0.012184269726276398,
-0.014234118163585663,
0.010063542984426022,
-0.011024367064237595,
0.023221254348754883,
0.007513283286243677,
0.019687339663505554,
-0.01854301057755947,
0.007631439715623856,
0.0006610171403735876,
0.023549221456050873,
0.010594690218567848,
0.01542348600924015,
0.00977840181440115,
-0.012935372069478035,
-0.004831603728234768,
0.025083443149924278,
0.006298515014350414,
-0.015061111189424992,
0.015148471109569073,
0.024563444778323174,
-0.0010694365482777357,
0.0028021633625030518,
-0.010011800564825535,
-0.015520015731453896,
-0.08154501020908356,
-0.005304170772433281,
-0.011064879596233368,
0.0033084989991039038,
0.0067709945142269135,
-0.005603819619864225,
-0.003954841755330563,
0.00970507226884365,
-0.006849072873592377,
0.0006281600799411535,
-0.013266552239656448,
-0.007995640859007835,
-0.005276588257402182,
0.004082102328538895,
0.004990717861801386,
-0.0017257396830245852,
0.006069908384233713,
0.0007779329316690564,
-0.029078049585223198,
-0.028537500649690628,
-0.0014580351999029517,
-0.006638805847615004,
0.008068084716796875,
0.008735070005059242,
0.0013285678578540683,
0.01849612221121788,
-0.005164229776710272,
-0.0003890162333846092,
-0.0029883801471441984,
0.01760558784008026,
0.006115124095231295,
-0.014017663896083832,
0.016296450048685074,
-0.0183002520352602,
-0.038259126245975494,
-0.009780270978808403,
-0.023174848407506943,
-0.013171743601560593,
-0.005618649069219828,
0.02397622913122177,
-0.008576197549700737,
0.012110753916203976,
0.0021347850561141968,
-0.007981671020388603,
-0.011390425264835358,
0.0013784022303298116,
0.004203453194350004,
0.023531291633844376,
0.015834974125027657,
-0.006713955197483301,
-0.004593152552843094,
-0.012978730723261833,
0.0026278800796717405,
0.017961792647838593,
-0.009188919328153133,
0.0003401222638785839,
-0.0139747504144907,
0.0029559198301285505,
-0.009144777432084084,
-0.010752424597740173,
-0.0185706727206707,
0.006697278469800949,
0.022615935653448105,
-0.007144441362470388,
0.0008038117084652185,
-0.005006338935345411,
0.002848478266969323,
0.002432631328701973,
-0.010503649711608887,
0.0006531915860250592,
0.004366474226117134,
0.0037531517446041107,
0.00524382246658206,
-0.008929683826863766,
-0.01591331884264946,
-0.007280007936060429,
-0.01247192732989788,
-0.005222050938755274,
0.0003137378953397274,
-0.0074943071231245995,
-0.007747421972453594,
0.0001922232040669769,
-0.01056806743144989,
0.00009544403292238712,
-0.021393118426203728,
-0.011744188144803047,
0.011795289814472198,
0.02031935751438141,
0.02352786436676979,
-0.012213051319122314,
-0.02382250316441059,
0.031004024669528008,
0.01430921908468008,
0.008486009202897549,
0.013263577595353127,
-0.02778938040137291,
0.009321274235844612,
-0.024407856166362762,
0.008552715182304382,
0.006585048045963049,
-0.005856896284967661,
-0.010460768826305866,
0.0019124699756503105,
-0.00708368606865406,
-0.029053350910544395,
0.011585917323827744,
0.012963091023266315,
0.004439495503902435,
-0.007700714282691479,
-0.005672917701303959,
-0.04241348057985306,
-0.0027942026499658823,
0.00009044969920068979,
-0.03128524124622345,
0.007922143675386906,
0.01848280243575573,
0.012764431536197662,
-0.004094964358955622,
0.07270366698503494,
0.0006876080296933651,
0.0005031502805650234,
-0.01403634063899517,
0.004704983904957771,
-0.0062006376683712006,
0.01016880851238966,
0.007494565565139055,
0.030606327578425407,
-0.03113923966884613,
0.010944054462015629,
-0.02116263285279274,
0.023253794759511948,
-0.011672758497297764,
0.0041565499268472195,
-0.011782914400100708,
-0.017056014388799667,
-0.0023291935212910175,
-0.020676642656326294,
-0.005789811722934246,
0.01797848381102085,
-0.003312348620966077,
-0.023026909679174423,
0.012018606066703796,
0.0069971466436982155,
0.002795472042635083,
-0.00008776504546403885,
-0.014692706987261772,
-0.025216657668352127,
0.011303308419883251,
0.005495649296790361,
-0.005140462424606085,
-0.007938630878925323,
-0.007899252697825432,
0.007760913111269474,
-0.011053785681724548,
-0.014726979658007622,
0.02966751717031002,
-0.006132226437330246,
0.01850849948823452,
-0.01826247200369835,
-0.009869176894426346,
0.017107754945755005,
-0.0029517707880586386,
0.011268860660493374,
0.0011318891774863005,
0.026055525988340378,
-0.0038495531771332026,
-0.015658674761652946,
-0.014949650503695011,
-0.011880716308951378,
0.009786182083189487,
0.011488037183880806,
-0.005655827932059765,
-0.018599148839712143,
0.011998668313026428,
0.00809839740395546,
-0.0031401102896779776,
-0.03017207235097885,
0.00808852631598711,
0.009612394496798515,
-0.02722521498799324,
0.002013711491599679,
-0.01095728948712349,
-0.013646000996232033,
-0.01029290072619915,
0.005396972876042128,
-0.008313227444887161,
-0.03222811967134476,
-0.010779788717627525,
-0.000041925814002752304,
-0.021197853609919548,
-0.005856365896761417,
-0.00906803272664547,
-0.012385767884552479,
0.021539438515901566,
-0.00516920629888773,
0.005306406877934933,
0.0172024704515934,
-0.015478457324206829,
0.0019227336160838604,
0.006327368784695864,
0.0022173277102410793,
-0.006651122588664293,
0.016848137602210045,
-0.00025058165192604065,
0.013629461638629436,
-0.07498051226139069,
-0.020358800888061523,
0.00203963415697217,
-0.015834391117095947,
-0.014961646869778633,
0.01145694125443697,
-0.018618233501911163,
0.010829484090209007,
-0.018924497067928314,
-0.0045599858276546,
-0.0025116214528679848,
0.02571035549044609,
0.005494221113622189,
-0.008735802955925465,
0.01421389915049076,
0.020354777574539185,
0.024072177708148956,
0.008371254429221153,
-0.013880738988518715,
0.0036804249975830317,
0.0005100993439555168,
0.029813110828399658,
-0.03318248689174652,
-0.00030901332502253354,
-0.004193035885691643,
-0.08151140809059143,
-0.010567324236035347,
-0.004330547526478767,
-0.005145207513123751,
-0.006455807480961084,
-0.00882625114172697,
0.009294203482568264,
-0.008807608857750893,
-0.01267206110060215,
-0.013589299283921719,
0.007799803279340267,
-0.003775750519707799,
0.004019886255264282,
-0.0194723978638649,
0.006022603716701269,
-0.0074423872865736485,
0.016407838091254234,
0.0046221171505749226,
-0.0007518203929066658,
0.002813299186527729,
0.015914199873805046,
0.0024088583886623383,
-0.00392194464802742,
0.009138382971286774,
-0.01432288158684969,
0.01021529734134674,
0.006358054466545582,
0.008847884833812714,
0.014644930139183998,
-0.04104992747306824,
0.00029989564791321754,
-0.010701197199523449,
0.0013601977843791246,
-0.011901642195880413,
-0.0054422239772975445,
-0.014081205241382122,
0.007851151749491692,
-0.006016009021550417,
-0.009690963663160801,
0.0028343885205686092,
0.00193353823851794,
0.029022878035902977,
0.005145483650267124,
-0.009140586480498314,
0.01191425509750843,
0.0034674606285989285,
0.008447455242276192,
-0.015346668660640717,
0.006852529011666775,
-0.017115237191319466,
0.0013102632947266102,
-0.004091738723218441,
0.001169476192444563,
0.014429822564125061,
-0.010512230917811394,
-0.017132092267274857,
-0.02415209263563156,
0.00010645249858498573,
0.0016245674341917038,
0.00952001940459013,
-0.0058472841046750546,
0.007310768589377403,
0.00513351708650589,
0.07206693291664124,
-0.007165603339672089,
0.0159466490149498,
-0.0005877004005014896,
-0.012551294639706612,
0.0028061973862349987,
-0.031222330406308174,
-0.005473540164530277,
-0.02321118861436844,
-0.005174110643565655,
0.009671133011579514,
-0.006595979910343885,
0.008772052824497223,
0.00892589520663023,
-0.016206244006752968,
-0.031680576503276825,
0.030221501365303993,
0.028640266507864,
-0.0094776451587677,
0.008247431367635727,
0.014434440061450005,
-0.019104313105344772,
-0.01834695041179657,
-0.022806301712989807,
-0.007399531081318855,
0.006446514278650284,
0.014520745724439621,
0.008741674944758415,
0.002963213250041008,
0.001162747386842966,
-0.0018633878789842129,
0.016212396323680878,
0.01731705665588379,
0.001715946476906538,
0.00337334000505507,
-0.012815874069929123,
-0.0027908298652619123,
0.01076754741370678,
-0.008960722014307976,
0.014200018718838692,
0.024892129004001617,
-0.014874845743179321,
0.006171493791043758,
-0.013865642249584198,
0.030839581042528152,
-0.011881817132234573,
0.015319062396883965,
0.027353566139936447,
-0.006001227535307407,
0.012299424968659878,
-0.002988006453961134,
0.01335788331925869,
0.01965039037168026,
0.0067337267100811005,
-0.014116555452346802,
0.010224147699773312,
0.005583448801189661,
0.01585879921913147,
0.0074014971032738686,
0.00925071258097887,
0.018263597041368484,
-0.008502550423145294,
-0.0037370400968939066,
-0.014363700523972511,
0.007372711319476366,
-0.0004556095227599144,
0.019696058705449104,
0.000891552830580622,
-0.007919327355921268,
0.008494250476360321,
-0.002089862246066332,
0.0063688382506370544,
0.008970597758889198,
-0.010112428106367588,
-0.010029948316514492,
0.017317883670330048,
-0.0003847571788355708,
0.014830263331532478,
0.0001483582891523838,
0.005268597975373268,
-0.018349390476942062,
-0.014556102454662323,
-0.009249236434698105,
0.011937394738197327,
-0.004415222443640232,
0.008166221901774406,
0.005632362794131041,
-0.003512623719871044,
-0.017221663147211075,
-0.0017144862795248628,
0.0010763758327811956,
0.01716768369078636,
-0.003072710009291768,
0.005100404843688011,
0.00787669699639082,
0.034058429300785065,
0.020638003945350647,
-0.000609425303991884,
0.0020957770757377148,
0.003626869525760412,
0.021268993616104126,
-0.023643838241696358,
0.0036726384423673153,
0.010113340802490711,
-0.0013154044281691313,
0.0012903448659926653,
-0.002688057254999876,
-0.01241962518543005,
-0.014938385225832462,
0.03092120587825775,
-0.019323434680700302,
-0.029644455760717392,
0.04111757129430771,
-0.011553825810551643,
0.0036469565238803625,
0.0183558389544487,
-0.0015128597151488066,
-0.025970876216888428,
-0.0013121617957949638,
-0.012232949957251549,
-0.003218600759282708,
0.0019010193645954132,
0.0024567856453359127,
-0.005232124123722315,
0.015147283673286438,
-0.01684838905930519,
-0.004958242177963257,
0.01102979015558958,
0.011475885286927223,
0.005450740456581116,
0.01660756953060627,
-0.039181675761938095,
-0.025462402030825615,
0.009763828478753567,
-0.01622939109802246,
-0.005438075866550207,
-0.0086793452501297,
0.019034720957279205,
-0.021463649347424507,
-0.021812107414007187,
0.013438217341899872,
-0.006729471497237682,
0.0027744078543037176,
-0.015046697109937668,
0.010381406173110008,
-0.007624852005392313,
0.000676245428621769,
-0.013647966086864471,
0.008239107206463814,
0.01431632973253727,
-0.023294972255825996,
-0.004093917086720467,
0.024165447801351547,
-0.005259853322058916,
0.0378573015332222,
0.015308275818824768,
0.029777642339468002,
-0.030695989727973938,
0.022889332845807076,
-0.025218389928340912,
-0.02971155196428299,
-0.011608184315264225,
-0.002035954035818577,
0.010701822116971016,
0.008384950459003448,
0.00649163406342268,
-0.003450374584645033,
0.004455749876797199,
0.003960047848522663,
-0.004349257331341505,
0.00605213874951005,
0.004781106021255255,
0.022850852459669113,
0.017390357330441475,
0.009824145585298538,
0.0043786801397800446,
-0.0053165871649980545,
-0.006491311825811863,
-0.00812799297273159,
0.015128991566598415,
0.0004941486986353993,
-0.01809704862535,
-0.013417327776551247,
-0.010265728458762169,
0.0017064474523067474,
-0.005267955828458071,
-0.016200028359889984,
-0.018932946026325226,
-0.000036852783523499966,
0.012050433084368706,
-0.0005574598908424377,
-0.006750343833118677,
0.004940767772495747,
0.009961146861314774,
0.002540579764172435,
0.025313669815659523,
-0.002304710913449526,
-0.02080492489039898,
0.0009909442160278559,
0.011657570488750935,
0.008348828181624413,
-0.03817630559206009
] | [
-0.14653825759887695,
-0.5970363020896912,
0.5235241651535034,
0.09941631555557251,
0.1430543065071106,
-0.16011933982372284,
0.9046710729598999,
-0.6002405881881714,
-0.41407108306884766,
0.033338192850351334,
-0.19154410064220428,
0.29430580139160156,
-0.29377254843711853,
-0.03661958873271942,
0.2846783399581909,
0.842981219291687,
0.17125080525875092,
0.12653391063213348,
-0.2763417065143585,
-0.8449828624725342,
-0.09413022547960281,
-0.0402798131108284,
0.6866329312324524,
0.03883056342601776,
0.031377341598272324,
-0.5257840156555176,
-0.05203576013445854,
-0.1300496906042099,
-0.036752909421920776,
-0.28579282760620117,
-0.1472156047821045,
0.5504876971244812,
-0.1244419664144516,
-0.18550539016723633,
0.697162389755249,
0.41385897994041443,
0.12318094819784164,
-0.09360133856534958,
-0.4549020230770111,
-0.3623231053352356,
-0.37085428833961487,
-0.04348583519458771,
-0.10537710040807724,
0.008230919949710369,
-0.15982769429683685,
0.002061898587271571,
-0.5066509246826172,
0.14259640872478485,
0.1818075031042099,
-0.1564321666955948,
-0.1494983285665512,
-0.047341056168079376,
0.7433488965034485,
0.14227047562599182,
0.014201721176505089,
-0.5991947054862976,
-0.5628608465194702,
-0.00520237535238266,
0.15930765867233276,
-0.16292279958724976,
0.7242451310157776,
0.022766318172216415,
-0.10365048795938492,
0.44476959109306335,
-0.23401711881160736,
0.18693296611309052,
0.0008441746467724442,
-0.06097402051091194,
0.10292720794677734,
0.10050363838672638,
0.514968752861023,
-0.04297468066215515,
-0.30284756422042847,
0.07576291263103485,
-0.008955965749919415,
0.3538108468055725,
-0.27348604798316956,
-0.4985751211643219,
0.0649300292134285,
-0.05689208209514618,
-0.1772100031375885,
0.006137610413134098,
0.544646143913269,
-0.11101707071065903,
0.26115888357162476,
0.07681579887866974,
0.06598104536533356,
0.23690524697303772,
0.12755775451660156,
0.24645444750785828,
0.02703237347304821,
0.02664068154990673,
0.7661084532737732,
0.4569820165634155,
-0.24936485290527344,
0.1377895474433899,
-0.40949732065200806,
0.1074012741446495,
-0.1907067447900772,
0.027447927743196487,
0.02071790024638176,
-0.5982497334480286,
-0.1638181507587433,
-0.36566975712776184,
-0.18485307693481445,
0.02485962212085724,
0.02628571353852749,
-0.6194623112678528,
-0.08651696890592575,
0.4638597369194031,
-0.9687745571136475,
0.09584493190050125,
-0.1302686482667923,
-0.4466681182384491,
-0.6461674571037292,
-0.3131226599216461,
0.17016959190368652,
-0.07573884725570679,
0.2943478524684906,
0.11209730058908463,
-0.07103272527456284,
0.49921074509620667,
0.12974558770656586,
0.09223807603120804,
0.09069935977458954,
-0.2421056628227234,
0.35057875514030457,
0.2630719244480133,
-0.013513759709894657,
0.03209831193089485,
0.2015911042690277,
0.6036511063575745,
-0.23070387542247772,
0.004643797874450684,
-0.6181800365447998,
0.21311591565608978,
-0.06604136526584625,
0.4614863395690918,
0.21901175379753113,
0.029450049623847008,
-0.3738940358161926,
-0.1764492392539978,
-0.5782084465026855,
-0.06516104191541672,
0.0793854147195816,
-0.4976402223110199,
0.10642426460981369,
0.24985182285308838,
-0.003646047553047538,
-0.3450751006603241,
-0.38934215903282166,
-0.2844509482383728,
-0.4138076901435852,
0.07534855604171753,
0.21401989459991455,
-0.573596715927124,
-0.308066725730896,
0.19412696361541748,
-0.022415420040488243,
-0.30782970786094666,
0.10660068690776825,
0.311977356672287,
-0.4336109161376953,
0.17957088351249695,
0.6891474723815918,
0.32412728667259216,
-0.018368439748883247,
0.21935224533081055,
-0.08287004381418228,
0.12412664294242859,
-0.5961427688598633,
0.20268455147743225,
0.17147250473499298,
-0.7810998558998108,
-1.108407735824585,
0.027337465435266495,
0.1407196819782257,
0.45981794595718384,
0.1443207561969757,
-0.22169947624206543,
-0.6097546815872192,
-0.43313780426979065,
-0.03658755496144295,
-0.16691546142101288,
0.29865768551826477,
-0.2284604012966156,
0.2425125539302826,
-0.05552642047405243,
-0.067043237388134,
0.1134723424911499,
0.06720287352800369,
0.20787765085697174,
0.6064750552177429,
-0.6281465291976929,
0.4744921326637268,
-0.29696124792099,
0.29224693775177,
1.441173791885376,
0.335915744304657,
-0.14196205139160156,
0.18519383668899536,
0.09443315863609314,
0.32977139949798584,
-0.1749631017446518,
-0.7002937197685242,
0.6064670085906982,
-0.00993346981704235,
0.04796353727579117,
-0.3011821210384369,
-0.3251706659793854,
-0.035975273698568344,
-0.0930442363023758,
-0.16120333969593048,
0.05703476816415787,
0.03259449079632759,
-0.24604496359825134,
-0.19028539955615997,
0.03649938851594925,
0.19144567847251892,
-0.353107750415802,
0.4506455063819885,
-0.21170973777770996,
0.4198986887931824,
0.5504580736160278,
-0.3049842119216919,
0.5215295553207397,
0.6547319889068604,
0.32780277729034424,
0.5865663886070251,
-0.6027848720550537,
-0.0008572596707381308,
-0.9845343232154846,
0.14328867197036743,
0.38678088784217834,
-0.1922660917043686,
0.3639848530292511,
-0.24963586032390594,
-0.35924655199050903,
0.08389027416706085,
-0.38869622349739075,
0.4668460190296173,
0.11364461481571198,
0.04216964170336723,
0.6778520941734314,
0.09293907135725021,
0.2810634970664978,
-0.2061861753463745,
0.7768735885620117,
-0.37186041474342346,
0.34809401631355286,
0.5148481130599976,
0.21032771468162537,
0.42988210916519165,
-0.0841594785451889,
0.08217082172632217,
0.22301022708415985,
-0.270491361618042,
-0.07470108568668365,
0.3796158730983734,
-0.1563638150691986,
0.05688457936048508,
0.26290270686149597,
0.31022801995277405,
0.16027480363845825,
0.030403228476643562,
-0.8007557988166809,
-1.4340513944625854,
-0.8976656794548035,
0.6611115336418152,
0.49493762850761414,
0.37680885195732117,
-0.08310730755329132,
-0.7690175771713257,
0.025593861937522888,
-0.2253415584564209,
-0.2811862528324127,
0.7463272213935852,
0.3731044828891754,
-0.6642045974731445,
0.14782309532165527,
0.2268342673778534,
0.16273854672908783,
0.955889105796814,
-0.08234206587076187,
-0.05814897641539574,
0.09126865118741989,
0.18551768362522125,
-0.19271759688854218,
-0.4658609926700592,
-0.3364695608615875,
-0.03204017132520676,
0.33148154616355896,
0.07414814084768295,
-0.25455284118652344,
0.4109410345554352,
0.3114612102508545,
-0.34839755296707153,
0.4805113673210144,
0.7080300450325012,
0.035463061183691025,
-0.25809887051582336,
-0.10943002253770828,
-0.1831768900156021,
-0.20689673721790314,
-0.06367757171392441,
-0.23225808143615723,
-0.07176141440868378,
0.07641314715147018,
-6.016114234924316,
0.05427703633904457,
-0.42509305477142334,
0.1476752609014511,
-0.9150750637054443,
0.04516828432679176,
1.2713173627853394,
-0.5515871047973633,
-0.4642351567745209,
0.03318774700164795,
0.14984096586704254,
0.25460952520370483,
0.4406234622001648,
0.2602933645248413,
-0.09423964470624924,
0.1651221364736557,
0.03708288446068764,
-0.41089922189712524,
0.26763495802879333,
-0.2067912071943283,
0.4382438659667969,
0.053370945155620575,
-0.09877587109804153,
0.022382477298378944,
0.415709912776947,
0.34663504362106323,
-0.18146558105945587,
-0.10513707250356674,
-0.518980085849762,
-0.2281082421541214,
-0.3755853772163391,
-0.5941609144210815,
-0.14568273723125458,
0.13230301439762115,
0.8563714027404785,
-0.16607727110385895,
0.42907947301864624,
0.2409365326166153,
0.14006145298480988,
-0.3457010090351105,
-0.11040864139795303,
0.0001886061654658988,
0.09239231795072556,
-0.0329303964972496,
-0.06533694267272949,
-0.0029610865749418736,
0.1021328940987587,
-0.13716401159763336,
0.06631196290254593,
0.3093078136444092,
-0.24782517552375793,
-0.040194932371377945,
0.1792663186788559,
0.29516708850860596,
-0.11209381371736526,
0.27210772037506104,
-0.1483270674943924,
-0.27753737568855286,
-0.287388414144516,
0.30703312158584595,
-0.09363406896591187,
0.06751671433448792,
0.18479986488819122,
-0.8903120160102844,
0.3290891945362091,
0.2131386250257492,
-0.6508200764656067,
-0.2651114761829376,
0.2977641522884369,
0.7292596101760864,
-0.46001091599464417,
-0.056666888296604156,
0.6211737394332886,
-0.875546932220459,
0.5726242661476135,
-0.43807610869407654,
0.04948614910244942,
0.03415481373667717,
0.1230325922369957,
0.006804563570767641,
-0.04274911433458328,
-0.08842349052429199,
-0.15579283237457275,
-0.14462344348430634,
0.1204565018415451,
-0.4997447431087494,
0.13642491400241852,
0.012952752411365509,
0.10611525923013687,
0.618914008140564,
0.19791921973228455,
0.032965220510959625,
0.2206108272075653,
0.08807547390460968,
-0.11743591725826263,
0.6849269270896912,
0.3224492371082306,
-0.18804508447647095,
0.6745969653129578,
0.32592979073524475,
0.47123581171035767,
-0.08901416510343552,
0.07387147098779678,
-0.8664460182189941,
-0.5484856963157654,
0.43464720249176025,
-0.3027811348438263,
0.11990007758140564,
0.7507364749908447,
-0.46915340423583984,
0.1568906307220459,
0.037309665232896805,
-0.24178346991539001,
-0.26360777020454407,
0.41848626732826233,
-0.5371131896972656,
-0.15600554645061493,
0.18315868079662323,
0.1601981520652771,
-0.28137707710266113,
0.1656268835067749,
-0.0654320940375328,
-0.42135894298553467,
0.22753508388996124,
-0.46838635206222534,
-0.15200930833816528,
0.17898733913898468,
-0.04761705920100212,
-0.243805930018425,
-0.03672254830598831,
-0.20900942385196686,
0.11837991327047348,
0.16730718314647675,
-0.13033437728881836,
-0.09872742742300034,
-0.5760934352874756,
-0.16902048885822296,
0.1634313017129898,
-0.031235255300998688,
-0.38349848985671997,
-0.2784246504306793,
0.3716036081314087,
-0.13001304864883423,
-0.12412496656179428,
0.051911741495132446,
-0.19917356967926025,
0.3059310019016266,
-0.2797447741031647,
-0.3020564317703247,
0.2200441211462021,
0.4863024652004242,
-0.4618220031261444,
0.5410001277923584,
-0.003607650985941291,
-0.5411612391471863,
-0.01752321422100067,
0.42393985390663147,
-0.013149977661669254,
0.4154849052429199,
-0.22357626259326935,
0.42685195803642273,
0.25471365451812744,
-1.6909716129302979,
-0.03535115718841553,
0.1986427754163742,
-0.8202741742134094,
-0.14386053383350372,
-0.33485519886016846,
0.16768990457057953,
-0.2356238067150116,
-0.20201076567173004,
-0.5615581274032593,
-0.1478879749774933,
0.0910569578409195,
0.2489679902791977,
-0.030594758689403534,
-0.27936190366744995,
-0.25756698846817017,
-0.07747866958379745,
0.3281695544719696,
0.33610260486602783,
0.05299241840839386,
-0.6488553285598755,
0.37617605924606323,
0.3359829783439636,
0.37091487646102905,
-0.09229738265275955,
0.0029525517020374537,
-0.2564334571361542,
-0.25209933519363403,
0.6653635501861572,
0.29751256108283997,
0.03168816491961479,
-0.321174681186676,
0.24778881669044495,
-0.25953608751296997,
0.23633238673210144,
1.4296141862869263,
-0.3986223042011261,
0.40382036566734314,
-0.1989525407552719,
-0.13085222244262695,
-0.003596939379349351,
0.5365646481513977,
0.19590409100055695,
0.17286774516105652,
0.1378689408302307,
0.23630230128765106,
-0.4380132257938385,
-0.15162824094295502,
-0.4984038472175598,
-0.5993728637695312,
-0.011631184257566929,
0.39005687832832336,
0.15276962518692017,
0.5584636926651001,
-0.24106884002685547,
-0.40508270263671875,
-0.3921717703342438,
0.2102542221546173,
0.4264663755893707,
0.1501287817955017,
0.07552062720060349,
-0.07452715188264847,
-0.3430761992931366,
0.46804797649383545,
0.3721875548362732,
-0.7482618689537048,
-0.04042424261569977,
0.0241144597530365,
-0.10170798748731613,
-0.0782584697008133,
0.24964408576488495,
0.030352236703038216,
-0.6089869737625122,
-0.2547263205051422,
-0.4905995726585388,
-0.15207821130752563,
-0.8815067410469055,
0.10402408242225647,
-0.05472971871495247,
0.6406183838844299,
-0.2799908220767975,
-0.3769271969795227,
-0.08361069858074188,
0.09953099489212036,
0.11945546418428421,
-0.43564802408218384,
-0.009296318516135216,
0.1063004657626152,
0.4792664051055908,
0.3642042279243469,
0.2830469012260437,
0.018728619441390038,
0.5611503720283508,
0.24260622262954712,
0.14943677186965942,
-0.21312306821346283,
0.19509835541248322,
0.4044506251811981,
0.26463913917541504,
0.3685879409313202,
-0.20397694408893585,
0.15636780858039856,
-0.2746555805206299,
0.4548575282096863,
0.2893312871456146,
-0.6061157584190369,
0.11330373585224152,
-0.6052542924880981,
0.25874897837638855,
0.2549750506877899,
0.2007714807987213,
0.17479465901851654,
0.03333330899477005,
0.48249977827072144,
-0.1042095273733139,
0.32641085982322693,
-0.16908983886241913,
0.2934218645095825,
-0.49073293805122375,
-0.8235663175582886,
-0.04522335156798363,
-0.401422381401062,
-0.26394301652908325,
-0.5619514584541321,
0.00551071111112833,
0.2484450340270996,
-0.6471585631370544,
0.24263796210289001,
-0.12210262566804886,
0.13451817631721497,
-0.7521616220474243,
-0.1584002673625946,
-0.06260687857866287,
0.31706535816192627,
0.03364284709095955,
0.3636501431465149,
-0.5562539100646973,
-0.4626755714416504,
-0.5983840823173523,
-0.17956425249576569,
0.8507592678070068,
-0.319549560546875,
-0.7454236745834351,
0.0466817207634449,
0.4866897165775299,
-0.4430388808250427,
-0.5584694743156433,
-0.3755588233470917,
0.7240972518920898,
0.30872663855552673,
0.5504553914070129,
0.45076534152030945,
-0.3507659137248993,
-0.3150642216205597,
0.19831480085849762,
0.37328678369522095,
-0.12177153676748276,
0.18179406225681305,
0.10459880530834198,
0.0695376917719841,
0.3226930499076843,
-0.0687892735004425,
-0.4473186731338501,
0.3281063437461853,
-0.009228498674929142,
-0.026417173445224762,
-0.1003616452217102,
0.5943301916122437,
0.5654948949813843,
0.4909402132034302,
-0.20106016099452972,
0.9603922367095947,
-0.1469472348690033,
-0.07649698108434677,
-0.07222714275121689,
-0.5128324031829834,
-0.4337875247001648,
-0.0951651781797409,
1.8599671125411987,
0.4291123151779175,
0.30614614486694336,
-0.14732998609542847,
-0.25983408093452454,
0.16536611318588257,
0.14792825281620026,
0.31363001465797424,
0.10903859883546829,
-0.5205946564674377,
0.5362210869789124,
-0.18063916265964508,
0.19256354868412018,
-0.03272950276732445,
0.1166728138923645,
0.020651908591389656,
0.34048759937286377,
0.00019012927077710629,
-0.250354140996933,
0.17234499752521515,
-0.1350240707397461,
0.5605069994926453,
-0.08961783349514008,
0.049218762665987015,
-0.15313206613063812,
-0.40456491708755493,
0.13836069405078888,
0.4084387421607971,
-0.4557901620864868,
0.04713788256049156,
0.22097907960414886,
0.11423584818840027,
-0.6273066997528076,
-0.26770028471946716,
0.11919742822647095,
-0.382955402135849,
0.07446511089801788,
0.29849663376808167,
0.031206287443637848,
0.45770263671875,
-0.3433060944080353,
0.004379480145871639,
-0.3549204468727112,
-0.2313809096813202,
-0.4388766884803772,
0.03592657297849655,
-0.35533738136291504,
-0.4019034802913666,
0.05112261325120926,
0.07489609718322754,
0.41052016615867615,
-0.33021506667137146,
-0.4372882544994354,
0.10184303671121597,
0.2781170606613159,
-0.20824024081230164,
-0.36004579067230225,
0.22584110498428345,
0.6704792380332947,
0.3720560669898987,
0.2861703932285309,
-0.08888810873031616,
-0.22018159925937653,
0.13340440392494202,
-0.30028414726257324,
0.27244189381599426,
-0.4494365155696869,
-0.1350007951259613,
-0.5016854405403137,
0.21269771456718445,
0.7646927833557129,
0.3426468074321747,
-0.49515485763549805,
0.5911169052124023,
0.0961422324180603,
0.14252427220344543,
0.7831109166145325,
-0.7462567687034607,
-0.25120341777801514,
-0.5645465850830078,
-0.5670672655105591,
-0.10974029451608658,
0.487741082906723,
-0.17697149515151978,
0.14078140258789062,
0.18111415207386017,
-0.0955393984913826,
0.10829286277294159,
-0.1797240972518921,
0.5185551047325134,
-0.3184451758861542,
-0.7403523921966553,
-0.30961838364601135,
0.6267080307006836,
-0.8184844255447388,
0.24818573892116547,
-0.0022425188217312098,
0.009708069264888763,
0.1036691665649414,
0.16936808824539185,
0.0017248275689780712,
-0.3963366448879242,
0.1318829357624054,
0.12537610530853271,
0.28763842582702637,
0.02047961950302124,
-0.33586105704307556,
-0.26438185572624207,
-0.09469147771596909,
0.280738890171051,
-0.09820335358381271,
0.006854411214590073,
0.5418916940689087,
-0.11803349107503891,
-0.19087688624858856,
-0.10595069080591202,
-0.19611875712871552,
-0.11789247393608093,
-0.49682503938674927,
-0.0707489624619484
] |
In this review, we consider the potential functional role of beta-band oscillations, which at present is not yet well understood. We discuss evidence from recent studies on top-down mechanisms involved in cognitive processing, on the motor system and on the pathophysiology of movement disorders that suggest a unifying hypothesis: beta-band activity seems related to the maintenance of the current sensorimotor or cognitive state. We hypothesize that beta oscillations and/or coupling in the beta-band are expressed more strongly if the maintenance of the status quo is intended or predicted, than if a change is expected. Moreover, we suggest that pathological enhancement of beta-band activity is likely to result in an abnormal persistence of the status quo and a deterioration of flexible behavioural and cognitive control. | [
-0.023882605135440826,
0.013375566340982914,
-0.0006617184262722731,
0.02297217771410942,
0.046244457364082336,
-0.02811921015381813,
0.009807090274989605,
-0.014955440536141396,
-0.011755263432860374,
0.02030896209180355,
-0.01699211448431015,
0.03294102102518082,
-0.011008581146597862,
0.019135914742946625,
-0.011160428635776043,
0.020302994176745415,
-0.022294174879789352,
0.015099339187145233,
-0.00021886348258703947,
0.04080173745751381,
0.009461967274546623,
-0.01221015490591526,
0.0118286507204175,
-0.009165297262370586,
0.006833403836935759,
-0.018105894327163696,
-0.03495120257139206,
-0.0019255205988883972,
-0.00640126271173358,
0.001323827775195241,
-0.008720542304217815,
0.0010457623284310102,
0.0071459002792835236,
0.0011024605482816696,
0.008356945589184761,
0.0004075935576111078,
-0.00004194863140583038,
0.030622262507677078,
-0.021758154034614563,
-0.0037415623664855957,
0.0031719899270683527,
-0.006003265269100666,
-0.0013363026082515717,
-0.026393547654151917,
-0.0072588492184877396,
0.008817747235298157,
-0.0005749736446887255,
0.007413581945002079,
-0.016486868262290955,
0.008754059672355652,
-0.007354142609983683,
0.0025732473004609346,
-0.005594502203166485,
0.03300633653998375,
-0.006325783673673868,
-0.011536724865436554,
0.022012844681739807,
0.004304683767259121,
-0.03568840026855469,
-0.0011238516308367252,
-0.005750945769250393,
0.033918168395757675,
0.010974206030368805,
-0.03339062258601189,
0.00003078219015151262,
-0.06691791117191315,
0.009839225560426712,
0.0022536632604897022,
0.011285251006484032,
-0.024914231151342392,
-0.027162261307239532,
0.011376152746379375,
0.004778016358613968,
0.0028405417688190937,
0.008502273820340633,
-0.011300007812678814,
-0.0016235134098678827,
-0.0017915056087076664,
-0.0058875964023172855,
0.006594439968466759,
-0.005366564728319645,
-0.02066931128501892,
0.012436175718903542,
0.020152833312749863,
-0.003085344098508358,
-0.005612780340015888,
-0.023970087990164757,
0.004090560134500265,
-0.013718505389988422,
0.012499244883656502,
0.012801222503185272,
0.010825389996170998,
0.014569739811122417,
0.01572266034781933,
0.0026882393285632133,
0.008579644374549389,
-0.011218218132853508,
-0.016325728967785835,
0.0034860819578170776,
-0.03035876154899597,
-0.029483148828148842,
0.003529482986778021,
0.02835691347718239,
-0.008277706801891327,
0.014084167778491974,
0.008545181713998318,
-0.015148196369409561,
0.017768366262316704,
-0.021258680149912834,
0.009665749035775661,
0.0178997665643692,
-0.0018088241340592504,
0.012126078829169273,
0.015737339854240417,
0.019526684656739235,
-0.01578984223306179,
0.01336604543030262,
0.019917629659175873,
0.013017316348850727,
0.000006077345460653305,
0.016045330092310905,
0.03982008621096611,
0.009448421187698841,
-0.0007864227518439293,
0.0021096414420753717,
0.012647806666791439,
0.014821469783782959,
0.00328654982149601,
0.01410069689154625,
0.017084356397390366,
-0.010542504489421844,
0.0040961760096251965,
-0.022350357845425606,
0.018888205289840698,
0.015411442145705223,
-0.00246480293571949,
-0.024253148585557938,
-0.016386356204748154,
0.014018544927239418,
-0.006470197811722755,
0.019932832568883896,
0.012259363196790218,
-0.0023962066043168306,
0.014200406149029732,
0.01079189870506525,
0.005457668099552393,
-0.022163571789860725,
0.00007175526116043329,
0.00599522003903985,
-0.0119700375944376,
0.039161063730716705,
0.009967183694243431,
-0.019354339689016342,
-0.02367272973060608,
-0.01613587699830532,
0.013560199178755283,
-0.027882328256964684,
-0.004341775551438332,
0.0027723065577447414,
0.012248174287378788,
-0.006650400813668966,
-0.00872536189854145,
0.020778309553861618,
0.009985307231545448,
0.025104591622948647,
0.05432727932929993,
0.024443307891488075,
-0.011366529390215874,
-0.000572883291170001,
0.002597016980871558,
-0.009617101401090622,
0.005541357211768627,
-0.015155250206589699,
0.011757750064134598,
-0.0024419063702225685,
0.004816947504878044,
0.01944822445511818,
0.010950349271297455,
-0.00490936916321516,
0.06712402403354645,
-0.009023355320096016,
0.018036402761936188,
0.012584934942424297,
0.02079370617866516,
0.002371444832533598,
-0.0019981362856924534,
0.011503376066684723,
-0.019247740507125854,
0.007721840403974056,
-0.03200501948595047,
-0.030556004494428635,
-0.013305999338626862,
0.0002737962640821934,
-0.004765240475535393,
0.005428534932434559,
0.003992166835814714,
0.028168953955173492,
0.011023799888789654,
-0.014434153214097023,
-0.009589144960045815,
0.01713450998067856,
-0.004466867074370384,
0.00037598609924316406,
-0.022013571113348007,
0.02173423394560814,
0.007547585293650627,
0.031135551631450653,
0.009327195584774017,
-0.022392461076378822,
-0.009403664618730545,
0.02128875069320202,
0.019961386919021606,
-0.023220764473080635,
-0.005767541937530041,
0.011764481663703918,
-0.0153192775323987,
-0.00465769600123167,
0.017192164435982704,
-0.009563354775309563,
-0.017772458493709564,
0.0018786138389259577,
0.004372211638838053,
0.015935756266117096,
-0.018055453896522522,
0.012561298906803131,
0.004552844911813736,
-0.02615221031010151,
0.016572140157222748,
0.010685085318982601,
0.01840946264564991,
-0.011544480919837952,
-0.008744130842387676,
-0.013863695785403252,
0.014662409201264381,
0.011502761393785477,
0.0017682318575680256,
0.014954155310988426,
0.0005445904098451138,
0.028117772191762924,
-0.012920498847961426,
-0.00200091116130352,
0.008201886899769306,
0.017129093408584595,
-0.0019013895653188229,
-0.023338917642831802,
-0.005148774478584528,
-0.004406016319990158,
0.008587812073528767,
0.016831157729029655,
-0.00522358575835824,
0.005275075323879719,
-0.017434149980545044,
0.00858935248106718,
-0.010078739374876022,
-0.002125317230820656,
-0.05159458518028259,
-0.0035911649465560913,
0.004527145065367222,
0.02176690101623535,
0.0010163555853068829,
0.00321025587618351,
0.005817187950015068,
0.01472725160419941,
0.01900821179151535,
-0.011335281655192375,
0.01629752106964588,
0.024256346747279167,
0.020389430224895477,
-0.0020890096202492714,
-0.0016947248950600624,
0.0053732069209218025,
-0.014910411089658737,
-0.009624000638723373,
-0.0810898169875145,
-0.02431485243141651,
-0.011806737631559372,
-0.010514919646084309,
0.0160335935652256,
0.010297931730747223,
0.011800670996308327,
0.01907692477107048,
-0.015213211998343468,
-0.0034802574664354324,
-0.006302095018327236,
-0.011823378503322601,
-0.008741909638047218,
-0.02770880237221718,
0.012377960607409477,
-0.011000270955264568,
0.010832229629158974,
0.008974541909992695,
0.01826348528265953,
-0.012490881606936455,
0.02331400290131569,
-0.022318460047245026,
-0.0011653299443423748,
0.025929631665349007,
-0.03754038363695145,
0.003387975273653865,
-0.006016234401613474,
-0.015053534880280495,
0.005530642345547676,
0.013920431956648827,
0.007755049504339695,
-0.00857010018080473,
-0.004318856634199619,
-0.013468751683831215,
0.006545867770910263,
-0.009130856022238731,
-0.004299471620470285,
-0.00001531466841697693,
-0.012187180109322071,
0.010232425294816494,
0.013826201669871807,
0.01076250709593296,
-0.03982901945710182,
0.009418158791959286,
-0.0006657401099801064,
-0.005062976852059364,
0.009060218930244446,
-0.014775560237467289,
0.009308643639087677,
-0.002176436362788081,
0.0098489448428154,
-0.0028915819711983204,
0.007651295978575945,
0.010646209120750427,
-0.013588683679699898,
-0.009629652835428715,
-0.03202152997255325,
0.003677729982882738,
-0.01312272623181343,
-0.00198654574342072,
-0.005611582659184933,
-0.017386186867952347,
-0.021732643246650696,
-0.004365268163383007,
0.020191727206110954,
0.0020562447607517242,
0.012529173865914345,
-0.007166706491261721,
-0.003199690952897072,
0.017717815935611725,
0.024905338883399963,
-0.0071467068046331406,
0.007060391828417778,
0.0040188198909163475,
-0.012260671705007553,
-0.010704176500439644,
-0.013283390551805496,
-0.012353546917438507,
0.00824070256203413,
-0.01686859130859375,
0.0030891606584191322,
0.01004951260983944,
-0.006351641844958067,
-0.00908556580543518,
-0.020028380677103996,
0.007126284763216972,
0.009463997557759285,
0.00908990204334259,
0.00923236832022667,
-0.014838999137282372,
-0.008511770516633987,
0.05068754404783249,
-0.012855409644544125,
0.004294089041650295,
0.03513646870851517,
-0.018779659643769264,
0.010187968611717224,
0.017354566603899002,
0.010191824287176132,
0.012404189445078373,
-0.016245119273662567,
-0.006725809536874294,
-0.034529317170381546,
-0.016115792095661163,
-0.019848966971039772,
0.01400462444871664,
0.011499445885419846,
-0.003531642723828554,
0.0032997666858136654,
-0.009578075259923935,
-0.003661221358925104,
-0.002797379158437252,
-0.004624960944056511,
0.024548839777708054,
0.022909922525286674,
0.004944030195474625,
0.007781067863106728,
0.01910853572189808,
0.07200314104557037,
0.005315848160535097,
0.0013218786334618926,
-0.0176240187138319,
0.04059474915266037,
-0.016422396525740623,
0.0022303713485598564,
0.005499875172972679,
0.031922951340675354,
-0.017571300268173218,
0.011106700636446476,
0.014046335592865944,
0.007281915284693241,
0.04758245870471001,
-0.01674414798617363,
0.008077339269220829,
0.011017762124538422,
-0.0018487684428691864,
-0.00650367746129632,
0.011183073744177818,
0.012079077772796154,
-0.020251285284757614,
-0.019023867323994637,
-0.003632165491580963,
0.022202668711543083,
-0.016840262338519096,
-0.012759201228618622,
-0.017429910600185394,
-0.012317709624767303,
-0.0007124678231775761,
-0.0036656158044934273,
-0.016530361026525497,
-0.004856927320361137,
-0.001699918881058693,
0.008541608229279518,
0.013885184191167355,
-0.0015375025104731321,
0.00628860667347908,
-0.0026226367335766554,
-0.011437419801950455,
-0.011678915470838547,
-0.01887175627052784,
0.02609376236796379,
0.02828150801360607,
0.015468749217689037,
-0.018146531656384468,
-0.019861772656440735,
-0.0003050418454222381,
0.004131964407861233,
0.025073979049921036,
-0.016705434769392014,
0.011151394806802273,
0.006949828006327152,
-0.017955925315618515,
0.0043093254789710045,
0.02228924259543419,
0.01814514398574829,
0.00046474672853946686,
-0.03987760469317436,
-0.008498045615851879,
-0.039598673582077026,
0.004729524254798889,
-0.008096154779195786,
-0.009744668379426003,
-0.005773453041911125,
-0.005765540059655905,
0.04052845388650894,
0.0029701171442866325,
-0.014890397898852825,
0.009861346334218979,
-0.01081022061407566,
-0.001976303057745099,
0.003969274926930666,
0.010192740708589554,
0.0022884507197886705,
-0.03919375315308571,
-0.004864290356636047,
-0.007651226595044136,
0.03168248385190964,
-0.024571556597948074,
-0.0013023456558585167,
-0.014048980548977852,
0.008059898391366005,
-0.026891052722930908,
-0.018805578351020813,
0.021819867193698883,
-0.010251212865114212,
-0.07360579073429108,
0.000160678057000041,
-0.006676971912384033,
-0.009701881557703018,
0.005822708364576101,
0.019548291340470314,
-0.01451094076037407,
-0.005360060837119818,
0.015877703204751015,
-0.004622372332960367,
-0.028887838125228882,
0.011778914369642735,
0.031389228999614716,
0.0011873492039740086,
0.01086057722568512,
0.0009155599400401115,
-0.013420411385595798,
0.011522413231432438,
-0.018071502447128296,
0.015513141639530659,
-0.011979805305600166,
0.02418668568134308,
-0.010317406617105007,
0.0010106208501383662,
0.014065622352063656,
-0.08073584735393524,
0.0008111842907965183,
-0.0018038341077044606,
0.01951640099287033,
-0.007983112707734108,
0.003742597997188568,
-0.002176492940634489,
-0.010468488559126854,
-0.014094645157456398,
-0.018702568486332893,
0.015049830079078674,
0.006234051194041967,
-0.010921958833932877,
0.0010799923911690712,
0.03274397924542427,
-0.008536208420991898,
0.012929481454193592,
0.028146376833319664,
-0.013181197457015514,
-0.014902396127581596,
0.025792863219976425,
0.003457640763372183,
-0.010661629028618336,
0.005444883368909359,
-0.013086354359984398,
0.0033682945650070906,
-0.03372405469417572,
0.014987373724579811,
0.017428753897547722,
-0.014309241436421871,
-0.0018082887399941683,
-0.006895993370562792,
-0.011331997811794281,
0.020253317430615425,
-0.02596934512257576,
-0.026769015938043594,
-0.023469801992177963,
0.00014781512436456978,
0.010074716061353683,
-0.01480496022850275,
-0.00556010939180851,
-0.012362131848931313,
0.004337089601904154,
-0.007723185699433088,
-0.010948910377919674,
0.0027774013578891754,
0.004527328535914421,
-0.0002444095443934202,
0.013116981834173203,
0.005518718622624874,
0.011112197302281857,
-0.02168719284236431,
0.026262935250997543,
-0.0098019540309906,
-0.0003705606795847416,
-0.006757669150829315,
0.0012817676179111004,
0.025579191744327545,
0.005908372811973095,
0.016186384484171867,
0.0008453266927972436,
0.037657372653484344,
-0.004205049015581608,
0.07230298221111298,
-0.0010397187434136868,
-0.0060445889830589294,
0.011402830481529236,
0.02321331575512886,
-0.004237343557178974,
-0.02329668030142784,
-0.006322185508906841,
0.01696384698152542,
-0.02771606668829918,
-0.032421864569187164,
-0.028179053217172623,
-0.018432453274726868,
0.011078821495175362,
0.007343353237956762,
-0.008807219564914703,
-0.00389407342299819,
0.0084641482681036,
-0.010135266929864883,
0.018568020313978195,
-0.013041366823017597,
-0.012749606743454933,
-0.02364344894886017,
0.007696257904171944,
0.004197489470243454,
-0.00017837685300037265,
0.020617246627807617,
0.023550642654299736,
0.005323159042745829,
-0.0086662033572793,
-0.015747904777526855,
-0.007121548056602478,
-0.001992026576772332,
-0.021157700568437576,
0.012764508835971355,
0.006886807736009359,
0.005156830884516239,
0.003384325420483947,
-0.01853885129094124,
-0.015305761247873306,
-0.012057037092745304,
0.030582312494516373,
0.0007126418058760464,
-0.014940215274691582,
-0.023400453850626945,
0.011591203510761261,
0.024283334612846375,
-0.017889531329274178,
0.025380274280905724,
0.022529486566781998,
-0.013217514380812645,
-0.006639676168560982,
0.016329629346728325,
0.00133534986525774,
0.023656459525227547,
-0.00008979206904768944,
0.006876022554934025,
0.016708627343177795,
-0.037716709077358246,
-0.03155119717121124,
-0.00465684849768877,
-0.012544175609946251,
-0.0144799267873168,
-0.010627895593643188,
-0.0070938728749752045,
0.022817794233560562,
0.003861058736220002,
-0.023665446788072586,
-0.006178027018904686,
0.01583407260477543,
0.0014296919107437134,
-0.0011658226139843464,
0.00705419247969985,
0.0016571101732552052,
-0.008118964731693268,
0.005670513957738876,
-0.0064776293002069,
0.004486544989049435,
0.007317298091948032,
0.010660585016012192,
-0.010622291825711727,
0.006669672671705484,
-0.015030739828944206,
-0.005755889695137739,
0.028144970536231995,
0.0017383649246767163,
-0.02097839117050171,
0.032555557787418365,
-0.011080162599682808,
0.012962093576788902,
-0.0023343097418546677,
-0.007555424235761166,
0.000703115772921592,
0.005577479023486376,
0.013187160715460777,
0.0328684076666832,
0.01188588049262762,
0.007286545820534229,
-0.021590186282992363,
-0.003945350646972656,
-0.005274859257042408,
0.00024338718503713608,
-0.02029668539762497,
0.01584271527826786,
-0.020125549286603928,
-0.0055808210745453835,
0.03512654826045036,
0.006806796882301569,
0.009707980789244175,
-0.004906533285975456,
-0.00881277583539486,
0.0027099396102130413,
0.015611817128956318,
0.009541500359773636,
0.0014494415372610092,
0.03399209678173065,
-0.022154171019792557,
-0.006955324672162533,
0.016700509935617447,
-0.007114280015230179,
0.029316149652004242,
0.002220646943897009,
-0.004370447248220444,
-0.006966330111026764,
-0.0010435087606310844,
-0.030821125954389572,
-0.01632004976272583,
0.006344770081341267,
-0.018668971955776215,
-0.005731812212616205,
-0.003093067090958357,
0.002196438377723098,
0.013271770440042019,
-0.004594487603753805,
-0.004770302213728428,
0.005773469805717468,
0.03758711367845535,
0.01146166492253542,
-0.0140597615391016,
0.00759589159861207,
0.05747979134321213,
-0.013328906148672104,
0.000909827125724405,
-0.006572077516466379,
0.008513905107975006,
-0.026572249829769135,
-0.00817623920738697,
0.024280374869704247,
0.011329445987939835,
-0.010861300863325596,
-0.0038195583038032055,
0.018928298726677895,
0.0030155021231621504,
-0.005614704452455044,
-0.03734711930155754,
0.03275718539953232,
0.011333226226270199,
0.008341701701283455,
-0.021472442895174026,
-0.023384466767311096,
-0.011080294847488403,
-0.011542190797626972,
-0.026325944811105728,
-0.005594002548605204,
0.007475223392248154,
0.01787639781832695,
-0.004667329136282206,
0.029702387750148773,
-0.021786201745271683,
-0.016277918592095375,
0.01613388955593109,
-0.013387189246714115,
0.007597866468131542,
0.03713938593864441,
-0.015005355700850487,
-0.009910350665450096,
0.01678655669093132,
0.012738324701786041,
0.020519286394119263,
0.0025652821641415358,
0.009917255491018295,
0.004459610674530268,
-0.01194473821669817,
-0.011514185927808285,
0.012125944718718529,
-0.02494833618402481,
-0.0019856630824506283,
-0.013535648584365845,
0.005021672695875168,
0.0069264816120266914,
0.009755630046129227,
-0.008837244473397732,
-0.016784172505140305,
-0.0064036231487989426,
-0.010344108566641808,
-0.01069269422441721,
-0.006702972110360861,
0.0024522007443010807,
0.00045798160135746,
-0.005752976052463055,
0.014348004944622517,
-0.027287669479846954
] | [
0.1387740969657898,
-0.3141283392906189,
0.45017150044441223,
0.10636509954929352,
0.03813957795500755,
-0.0336170457303524,
0.1635000854730606,
-0.14731280505657196,
-0.3850732445716858,
-0.49708762764930725,
-0.0733206570148468,
0.6489971876144409,
-0.4064064621925354,
0.30642950534820557,
-0.15464070439338684,
0.5457807183265686,
0.887570858001709,
0.22143694758415222,
-0.5546509027481079,
-0.6759973764419556,
-0.16956625878810883,
0.41274958848953247,
0.41438767313957214,
-0.18710584938526154,
-0.09054864943027496,
-0.18184465169906616,
0.35228660702705383,
0.10686890035867691,
-0.19405895471572876,
-0.08126237988471985,
-0.2242201268672943,
1.059243083000183,
-0.43354883790016174,
0.23624391853809357,
-0.1733192801475525,
0.44925281405448914,
0.05764554813504219,
-0.37506556510925293,
-0.06277698278427124,
-0.22846394777297974,
0.1007026880979538,
0.04721112549304962,
-0.3465877175331116,
0.5281668901443481,
-0.2908477485179901,
-0.30003049969673157,
-1.6045078039169312,
-0.01372724212706089,
0.07553001493215561,
-0.49949344992637634,
-0.006490452215075493,
0.4423597753047943,
0.7245990633964539,
0.3702898621559143,
-0.21969467401504517,
-0.16856510937213898,
-0.35651183128356934,
-0.07252302765846252,
0.37722188234329224,
-0.6469336748123169,
0.2466014325618744,
-0.09754815697669983,
-0.23846271634101868,
0.04420739412307739,
-0.2834089398384094,
0.2490006387233734,
0.337167888879776,
-0.13754232227802277,
-0.49608349800109863,
0.07179431617259979,
-0.18864339590072632,
-0.12224467098712921,
-0.34905919432640076,
0.015634385868906975,
-0.4712646007537842,
0.35521113872528076,
0.41224637627601624,
-0.04106462001800537,
-0.10818284004926682,
-0.342233270406723,
0.07250375300645828,
0.18689075112342834,
0.857062816619873,
-0.32484471797943115,
0.3191417157649994,
0.03435111045837402,
-0.20493802428245544,
0.4904547929763794,
-0.6250789165496826,
0.31668180227279663,
-0.40809866786003113,
-0.4073755443096161,
0.2105155736207962,
0.4321118891239166,
0.23136717081069946,
0.5872008800506592,
0.7673088908195496,
-0.28142642974853516,
0.18670929968357086,
0.03719645366072655,
0.31311190128326416,
-0.30126532912254333,
0.12420066446065903,
-0.1561041623353958,
0.1339161992073059,
-0.7902655601501465,
0.11279042810201645,
-0.9615529775619507,
-0.6546695828437805,
0.2865522503852844,
-1.0986279249191284,
0.30088067054748535,
0.20261944830417633,
-0.1407681107521057,
0.04432503506541252,
-0.04289405792951584,
-0.3142217695713043,
0.11994345486164093,
-0.1499599814414978,
0.34924831986427307,
0.37040796875953674,
1.2183648347854614,
-0.1434994488954544,
0.0011282144114375114,
-0.13487263023853302,
0.22439581155776978,
0.526395320892334,
0.03667309135198593,
-0.5838953852653503,
0.016704335808753967,
0.06334972381591797,
0.6071517467498779,
-0.37559086084365845,
-0.08783137798309326,
-0.12419359385967255,
0.0028492978308349848,
0.3614315688610077,
0.02238701470196247,
-0.019660118967294693,
0.3754168450832367,
0.013410386629402637,
-0.5694597959518433,
-0.5938801765441895,
-0.18795782327651978,
0.13074710965156555,
-0.21713069081306458,
-0.24727490544319153,
0.3726922571659088,
0.016541263088583946,
-0.03819630667567253,
-0.2719273567199707,
-0.00016526719264220446,
-0.5994368195533752,
0.0915156677365303,
-0.19853298366069794,
0.13413798809051514,
-0.28705111145973206,
-0.34151291847229004,
0.13380251824855804,
0.2774754762649536,
0.14135316014289856,
-0.1503525972366333,
-0.2195863127708435,
-0.323892742395401,
0.20528805255889893,
-0.2714182138442993,
0.07914901524782181,
0.18354859948158264,
0.013187548145651817,
0.026369955390691757,
-0.15822982788085938,
0.048435602337121964,
-0.0833989679813385,
-0.47127997875213623,
-0.032476410269737244,
0.17932705581188202,
0.17753095924854279,
0.3380593955516815,
-0.002799172652885318,
0.09890073537826538,
-0.8598514199256897,
-0.36714988946914673,
0.11919958889484406,
-0.5495774149894714,
0.29246219992637634,
0.14227283000946045,
0.23098979890346527,
-0.15145623683929443,
0.13649983704090118,
-0.444324254989624,
0.07243238389492035,
-0.1657496690750122,
0.4484527111053467,
-0.6481537818908691,
1.2090821266174316,
-0.1189938336610794,
0.05918281897902489,
0.9186555743217468,
0.4479311406612396,
-0.07259111851453781,
0.14303497970104218,
-0.37198904156684875,
0.2648346722126007,
0.1869572252035141,
-0.22541114687919617,
0.23831884562969208,
-0.17866306006908417,
-0.14461275935173035,
-0.1769883632659912,
-0.0007557357894256711,
0.4789923131465912,
-0.41424286365509033,
-0.026398664340376854,
-0.07191683351993561,
-0.011001053266227245,
-0.1216035708785057,
-0.2711963951587677,
0.015793437138199806,
-0.5972811579704285,
-0.049466945230960846,
0.13135431706905365,
-0.14438386261463165,
0.41842594742774963,
0.6248762011528015,
0.2664824426174164,
0.48320138454437256,
0.4965210258960724,
0.42325255274772644,
0.705130398273468,
-0.5138973593711853,
0.05687433108687401,
0.05984490364789963,
-0.06756448745727539,
-0.18992505967617035,
-0.20177650451660156,
0.11165907233953476,
0.02132526785135269,
-0.469919353723526,
-0.4225533604621887,
-0.3302288353443146,
-0.10735172033309937,
0.2633976936340332,
-0.7312214970588684,
0.8040119409561157,
0.06465253978967667,
-0.6109115481376648,
-0.11977624893188477,
0.5373200178146362,
-0.8670943379402161,
-0.15457689762115479,
0.19989113509655,
0.5312842130661011,
0.5230453610420227,
-0.8339175581932068,
-0.019694583490490913,
0.06304091960191727,
0.014269698411226273,
-0.3707444667816162,
0.13973361253738403,
-0.5179229974746704,
0.12472712248563766,
0.144251748919487,
-0.09714135527610779,
-0.11951042711734772,
-0.568116307258606,
-0.47587817907333374,
-0.6075342297554016,
-0.5709991455078125,
0.07598155736923218,
0.35422104597091675,
0.5022805333137512,
-0.18611347675323486,
-0.2820691466331482,
0.2942945659160614,
-0.28613874316215515,
-0.41315504908561707,
-0.04813161864876747,
0.44159576296806335,
-0.631649374961853,
-0.23288364708423615,
0.09206241369247437,
0.6682491898536682,
0.8425018191337585,
0.16464263200759888,
-0.7521688342094421,
-0.029052408412098885,
0.12022629380226135,
0.1472722440958023,
-0.0746433436870575,
-0.16526482999324799,
-0.2772098779678345,
0.054237138479948044,
-0.0379144549369812,
-0.0888657495379448,
0.1717446744441986,
0.6663494110107422,
0.14087842404842377,
0.331410676240921,
0.07229437679052353,
-0.0744338110089302,
-0.23198819160461426,
0.3856254518032074,
0.06447412818670273,
-0.2607579827308655,
0.030969733372330666,
-0.13515186309814453,
-1.0105175971984863,
0.460767537355423,
-6.047153472900391,
0.02828514575958252,
-0.13388119637966156,
-0.32550835609436035,
-0.4672764837741852,
0.11567042022943497,
0.7997099757194519,
0.11168119311332703,
0.029237549751996994,
0.17792820930480957,
0.09811529517173767,
0.10335160791873932,
-0.24269266426563263,
0.556715726852417,
-0.017043037340044975,
-0.33832305669784546,
0.16513307392597198,
-0.10988032817840576,
0.275561660528183,
0.26024535298347473,
0.39972126483917236,
-0.17475146055221558,
-0.18801409006118774,
0.4865894913673401,
-0.2402355968952179,
0.00472892913967371,
-0.7049349546432495,
-0.136332169175148,
-0.12982624769210815,
-0.6844611167907715,
-0.15744076669216156,
0.030477972701191902,
-0.26203644275665283,
-0.13233311474323273,
0.9826194047927856,
0.5746837258338928,
-0.22996583580970764,
0.11780005693435669,
0.0688743069767952,
-0.2932610511779785,
0.413843035697937,
0.595664381980896,
-0.049022916704416275,
0.23404374718666077,
0.07712234556674957,
0.5180135369300842,
-0.28533419966697693,
0.26409080624580383,
-0.6154477000236511,
0.7618592977523804,
-0.3072807788848877,
-0.33564454317092896,
0.17453624308109283,
0.04280390217900276,
0.2379404753446579,
-0.18186697363853455,
0.11866291612386703,
-0.2764720022678375,
-0.0905798077583313,
0.27948322892189026,
-0.2523004710674286,
-0.05224970355629921,
0.04693378508090973,
-0.7429367303848267,
-0.2863084375858307,
0.5219261050224304,
-1.1647536754608154,
-0.37299007177352905,
0.620887041091919,
0.11997056007385254,
-0.38294506072998047,
0.2381659597158432,
0.23955348134040833,
-0.6229215860366821,
0.38941389322280884,
-0.2407304048538208,
0.0790901854634285,
0.285126268863678,
-0.06074535846710205,
0.08151804655790329,
-0.026840394362807274,
0.09189635515213013,
0.09949178993701935,
-0.08111057430505753,
0.3007067143917084,
-0.2131912261247635,
-0.10729949921369553,
0.22455228865146637,
-0.31731754541397095,
0.46430864930152893,
0.5039609670639038,
-0.070225290954113,
0.13573245704174042,
0.5244854688644409,
0.265953928232193,
0.6299707293510437,
0.3530251383781433,
0.28197985887527466,
0.3702012896537781,
-0.27250391244888306,
0.6983396410942078,
-0.2831100523471832,
0.03608399257063866,
-0.40736207365989685,
-0.09894371777772903,
0.7725771069526672,
-0.39583373069763184,
-0.07738480716943741,
0.5404090285301208,
-0.48664534091949463,
0.3825746476650238,
-0.45977455377578735,
-0.1812835931777954,
-0.33063071966171265,
0.39927878975868225,
-0.23651863634586334,
-0.3095819056034088,
0.2509869933128357,
0.2681862711906433,
-0.15059998631477356,
0.23607900738716125,
-0.09771221876144409,
-0.44133973121643066,
0.15748237073421478,
-0.1325971782207489,
-0.06605365872383118,
-0.5065271258354187,
0.616760790348053,
-0.3808624744415283,
0.1988690197467804,
0.702431857585907,
0.23972097039222717,
-0.1773347407579422,
0.43097713589668274,
0.150503471493721,
-0.8912500739097595,
0.0462203323841095,
0.49882444739341736,
0.2782450318336487,
-0.6055687665939331,
0.37762153148651123,
-0.045612577348947525,
-0.1496446430683136,
-0.198394775390625,
0.1476883888244629,
-0.08836080878973007,
-0.09298881143331528,
-0.02027307078242302,
-0.5255356431007385,
0.21331597864627838,
0.22040453553199768,
-0.42035892605781555,
-0.1481897234916687,
-0.07520163804292679,
-0.11307598650455475,
0.200656920671463,
0.5286851525306702,
0.017652029171586037,
0.4887000620365143,
-0.3639272153377533,
0.1352880448102951,
-0.008369525894522667,
-0.9389276504516602,
0.13654708862304688,
0.05356540530920029,
0.05469200015068054,
-0.638637125492096,
-0.6157189011573792,
0.23507988452911377,
0.5421440005302429,
-0.21035856008529663,
-0.6973015666007996,
-0.5078412294387817,
-0.5179076790809631,
0.3379983901977539,
-0.271723210811615,
-0.12610182166099548,
0.25123393535614014,
-0.03618790581822395,
-0.2775310277938843,
0.021639933809638023,
-0.05293586850166321,
-0.5871483683586121,
0.17087982594966888,
0.47973737120628357,
-0.2239065170288086,
0.2788810431957245,
0.001714271609671414,
-0.22672687470912933,
-0.5692002177238464,
0.5302795767784119,
0.5772175788879395,
0.17819179594516754,
-0.17529411613941193,
0.4002472460269928,
-0.07471802830696106,
0.18790866434574127,
0.08739906549453735,
-0.17900195717811584,
-0.47926172614097595,
0.24807597696781158,
0.23803821206092834,
-0.3779463469982147,
0.6197972297668457,
0.5672844052314758,
-0.10263027250766754,
-0.0882720872759819,
0.19438214600086212,
-0.30339357256889343,
-0.11381660401821136,
-0.7071337103843689,
-0.6601731777191162,
0.022789711132645607,
-0.01829022355377674,
-0.0031370967626571655,
-0.03995437175035477,
0.21187333762645721,
-0.5038906335830688,
-0.5142733454704285,
0.6185623407363892,
0.30138126015663147,
-0.17892128229141235,
-0.3317151367664337,
-0.08110209554433823,
-0.22245557606220245,
-0.6651489734649658,
0.5659884810447693,
-0.3838776648044586,
0.21433740854263306,
-0.03742248937487602,
-0.4591250419616699,
0.13613063097000122,
0.2560819685459137,
-0.034843675792217255,
-0.463367760181427,
-0.6710512042045593,
-0.4543550908565521,
0.11714666336774826,
0.03129282221198082,
0.3341267704963684,
0.24814245104789734,
0.7813369035720825,
-0.21158769726753235,
-0.6499655842781067,
-0.46600887179374695,
0.24874010682106018,
0.5532281994819641,
-0.4237476885318756,
-0.22159582376480103,
0.2672768831253052,
0.5096701383590698,
0.15146386623382568,
0.06276725977659225,
0.4519038200378418,
0.8528999090194702,
-0.03642536327242851,
-0.12469295412302017,
-0.5694867372512817,
0.16118213534355164,
0.21180245280265808,
0.14497357606887817,
-0.30037662386894226,
-0.17974241077899933,
-0.3867785334587097,
-0.2695794403553009,
0.38108527660369873,
-0.4116475582122803,
-0.44551342725753784,
0.6004815697669983,
-0.5882325768470764,
0.5783170461654663,
-0.0837104544043541,
0.30319082736968994,
0.21483086049556732,
0.2957197427749634,
0.13513456284999847,
-0.003814913332462311,
0.4159415364265442,
0.0675351694226265,
0.0033201957121491432,
0.35081908106803894,
-0.23912589251995087,
0.12299691885709763,
-0.5448101758956909,
0.5140114426612854,
-0.5804059505462646,
0.12864786386489868,
-0.4500287175178528,
0.01617671735584736,
-0.4975239932537079,
-0.49837079644203186,
0.16248705983161926,
-0.3057699501514435,
-0.13010866940021515,
-0.30813419818878174,
0.15839235484600067,
0.45976725220680237,
0.29554200172424316,
0.06550116091966629,
-0.033073339611291885,
-0.38484352827072144,
0.09584245830774307,
0.322048157453537,
0.18029892444610596,
0.016935348510742188,
0.05604897066950798,
0.17345446348190308,
-0.1899101883172989,
-0.5485449433326721,
-0.045708026736974716,
0.38768330216407776,
0.09382574260234833,
0.3595852255821228,
0.8040993213653564,
-0.08626329153776169,
0.023190805688500404,
0.09853903949260712,
0.08266027271747589,
0.7638349533081055,
0.42153865098953247,
0.30659452080726624,
0.45617935061454773,
0.7658270001411438,
-0.19852368533611298,
-0.021021991968154907,
0.4204551577568054,
0.20756223797798157,
0.5178093314170837,
0.21427050232887268,
0.25267931818962097,
0.3910999894142151,
0.5884736776351929,
0.053000278770923615,
0.6789311766624451,
0.3126216530799866,
0.05965247005224228,
0.5084629058837891,
-0.40931612253189087,
-0.8227659463882446,
-0.03402332216501236,
0.5032225251197815,
0.02602553367614746,
-0.11074431985616684,
-0.01608024165034294,
-0.07655324786901474,
0.0746382474899292,
0.21929867565631866,
0.323112428188324,
-0.5308677554130554,
-0.05601867660880089,
0.2705225646495819,
-0.13527847826480865,
-0.17264176905155182,
0.16859909892082214,
0.06211951747536659,
-0.20001931488513947,
0.7458996176719666,
-0.4276573657989502,
-0.289020299911499,
0.43546903133392334,
-0.11644895374774933,
0.4653436541557312,
0.011533910408616066,
0.1810423731803894,
0.27103447914123535,
-0.2165316492319107,
0.36782485246658325,
0.27459198236465454,
0.29612693190574646,
-0.2695854604244232,
-0.0870770588517189,
0.1982293426990509,
-0.13300304114818573,
0.26245975494384766,
0.028588224202394485,
-0.6404613256454468,
0.3235146701335907,
-0.13574117422103882,
0.0908881351351738,
0.36499109864234924,
0.25131848454475403,
0.7122390866279602,
-0.2573051452636719,
-0.2786106765270233,
0.15607850253582,
-0.3033524453639984,
-0.2043984979391098,
0.25511983036994934,
0.06694938987493515,
-0.108619824051857,
0.011639363132417202,
-0.8500890731811523,
-0.45846396684646606,
0.12768617272377014,
0.09753783047199249,
0.003295670263469219,
-0.3209986984729767,
0.6022780537605286,
0.20719760656356812,
0.037960343062877655,
0.2431824654340744,
0.23238812386989594,
-0.509445309638977,
0.7103009819984436,
-0.053209882229566574,
0.10351797193288803,
-0.7459871768951416,
-0.13200123608112335,
-0.6649284362792969,
0.24104417860507965,
0.44621461629867554,
0.26509371399879456,
-0.25984835624694824,
0.2440091222524643,
0.30128613114356995,
0.031048458069562912,
0.5873493552207947,
-0.3678630590438843,
-0.3734951615333557,
-0.6387770771980286,
-0.08051081001758575,
-0.405895859003067,
0.6879422068595886,
-0.25122126936912537,
-0.021351274102926254,
-0.3256308436393738,
-0.026878707110881805,
0.03382493928074837,
-0.37037089467048645,
0.2281116545200348,
-0.2533462345600128,
-0.4405824542045593,
-0.40330925583839417,
0.29504987597465515,
-0.4621954560279846,
-0.5137170553207397,
-0.17434322834014893,
-0.04738740622997284,
0.6158624887466431,
-0.3748001456260681,
-0.024917850270867348,
-0.3539489507675171,
0.29680007696151733,
0.3543000817298889,
0.12967805564403534,
-0.044286224991083145,
-0.10369851440191269,
-0.5088861584663391,
-0.17295844852924347,
0.33792567253112793,
0.051808781921863556,
-0.44816961884498596,
-0.352674275636673,
-0.13253039121627808,
-0.25069567561149597,
-0.032023295760154724,
-0.07853744179010391,
-0.38905587792396545,
-0.24215061962604523,
-0.3957556188106537
] |
3016Background: T cell-based bispecific agents have shown activity in hematologic cancers, but solid tumor efficacy remains elusive. IMCgp100 is a bispecific biologic comprising an affinityenhanced TCR specific for gp100 and an anti-CD3 scFV. In vitro, IMCgp100 binds gp100+ melanoma cells causing redirection of cytotoxicity and induction of potent immune effects. Methods: The Phase I was conducted in HLA-A2+ pts with advanced melanoma, using a 3+3 design to define the MTD. Pts were treated with IMCgp100 (iv) weekly (QW, Arm 1) or daily (4QD3W, Arm 2) to evaluate safety, PK and efficacy. The recommended phase 2 regimen (RP2D-QW) was defined. Results: In the Ph I dose escalation,31 pts received doses from 5ng/kg to 900ng/kg. In arm 1 dose-limiting toxicity of gr 3 or 4 hypotension was seen and associated with rapid trafficking of peripheral lymphocytes to skin and tumor. The MTD was determined to be 600ng/kg QW. IMCgp100 has an approximately dose-proportional profile with a plasma T1/2 of 5-6 hrs at the RP2... | [
-0.0027951346710324287,
-0.002352335723116994,
-0.0062654390931129456,
0.009132523089647293,
0.010501362383365631,
0.002502023009583354,
0.007853474467992783,
-0.0026205391623079777,
-0.009240848943591118,
-0.01078343391418457,
-0.006621736101806164,
0.00546159315854311,
0.007984846830368042,
0.009373319335281849,
-0.004371114075183868,
-0.0163862444460392,
-0.0189568679779768,
0.024163341149687767,
0.011298123747110367,
0.013004133477807045,
0.006393333896994591,
-0.0035271255765110254,
0.008472971618175507,
-0.0017499362584203482,
0.01159322913736105,
0.008125592023134232,
-0.006841450929641724,
-0.006894227582961321,
-0.014290845952928066,
-0.02197955548763275,
0.0006667044945061207,
-0.0016332693630829453,
0.041540276259183884,
-0.007532756309956312,
0.00428127683699131,
-0.020365748554468155,
-0.006203584838658571,
0.017350614070892334,
0.02834930829703808,
-0.005533158779144287,
0.0031496414449065924,
-0.014939584769308567,
0.000060125370509922504,
-0.0256809089332819,
-0.00415631290525198,
-0.0030348915606737137,
-0.0035952813923358917,
0.021629922091960907,
0.008785100653767586,
0.010492859408259392,
-0.005989947356283665,
-0.005211696960031986,
-0.013719653710722923,
-0.009334495291113853,
-0.004660714417695999,
0.009070038795471191,
0.014185943640768528,
-0.005532556213438511,
0.000891480129212141,
0.009078513830900192,
0.012641679495573044,
-0.045070335268974304,
0.022374320775270462,
-0.012479250319302082,
0.001158826518803835,
-0.06749318540096283,
0.0011725954245775938,
0.026337770745158195,
-0.004183279816061258,
0.008345631882548332,
0.005261301528662443,
0.009388918057084084,
0.017503511160612106,
0.004508570302277803,
0.03473299741744995,
-0.011584695428609848,
-0.009750704281032085,
0.034766245633363724,
0.0085608446970582,
-0.0015172227285802364,
-0.02511288970708847,
-0.00723004387691617,
0.02162740007042885,
0.009488387033343315,
0.010406729765236378,
0.013883717358112335,
-0.012682795524597168,
-0.018885571509599686,
0.012298760935664177,
0.023000195622444153,
-0.007076586131006479,
-0.00037326780147850513,
-0.01593456044793129,
-0.015560785308480263,
-0.015924256294965744,
-0.01651996187865734,
0.01043538749217987,
-0.02719830349087715,
-0.005737559869885445,
0.011481445282697678,
-0.01973281055688858,
-0.0011532432399690151,
0.008148372173309326,
-0.004294846206903458,
-0.029113348573446274,
0.005719275213778019,
-0.025425929576158524,
0.02627624198794365,
0.029990971088409424,
0.01026919111609459,
-0.00644240528345108,
-0.011196243576705456,
-0.03003714047372341,
0.007013034541159868,
0.00570211885496974,
0.005110751371830702,
-0.0073948390781879425,
-0.01561812311410904,
0.013416329398751259,
0.0019074846059083939,
-0.016505785286426544,
0.007882429286837578,
0.0036046700552105904,
-0.0065597123466432095,
0.004199263174086809,
0.006373006384819746,
-0.015035622753202915,
0.014837994240224361,
0.010883648879826069,
0.0029624083545058966,
-0.0058802589774131775,
0.009559890255331993,
0.015033986419439316,
0.00929126888513565,
0.003544244449585676,
0.005295861046761274,
-0.013770338147878647,
-0.018723241984844208,
-0.010005410760641098,
-0.01157078891992569,
-0.013389366678893566,
0.004456143826246262,
0.004140425939112902,
-0.0008764479425735772,
-0.011846303008496761,
-0.003988189622759819,
-0.01924963667988777,
-0.00720467884093523,
-0.002658375073224306,
-0.003681683447211981,
-0.014156965538859367,
0.00340964924544096,
-0.022364439442753792,
-0.014517138712108135,
0.0046373046934604645,
-0.02034938335418701,
0.005773442331701517,
-0.021356429904699326,
-0.00030140788294374943,
0.01652982458472252,
0.013210631906986237,
-0.00918939895927906,
0.031085830181837082,
0.00820834469050169,
0.007731522433459759,
-0.018711362034082413,
-0.024642590433359146,
-0.006270195357501507,
0.005707456264644861,
0.005841299891471863,
-0.011455610394477844,
-0.0013852736447006464,
-0.004131412133574486,
0.0012369344476610422,
0.008747149258852005,
-0.006328486371785402,
0.0008761403150856495,
0.0063203079625964165,
-0.011693758890032768,
0.06676585972309113,
-0.008286158554255962,
0.009124848991632462,
0.005096060689538717,
-0.001513458788394928,
0.0057083358988165855,
-0.017651289701461792,
0.0052569154649972916,
-0.005256563425064087,
-0.013684472069144249,
-0.0030646491795778275,
-0.0010386500507593155,
-0.023489993065595627,
-0.028249479830265045,
0.008499149233102798,
-0.033003926277160645,
0.0021583782508969307,
0.013686021789908409,
0.0011667294893413782,
0.016998685896396637,
-0.005205939058214426,
0.0310991071164608,
-0.007305882405489683,
0.004416878800839186,
-0.000516493571922183,
0.015253961086273193,
0.015227708965539932,
0.005660883616656065,
-0.001782330684363842,
-0.018509961664676666,
-0.02911338210105896,
0.01217806339263916,
-0.03299915790557861,
-0.007304616272449493,
-0.008216951042413712,
-0.0007237412501126528,
0.00740412250161171,
0.00014071003533899784,
-0.006812138482928276,
-0.00516668101772666,
-0.01006997749209404,
-0.004686966072767973,
0.011792967095971107,
0.01509096845984459,
0.002284897956997156,
0.007531150709837675,
-0.015013204887509346,
0.01287965290248394,
0.00517352344468236,
0.008630694821476936,
0.00023150071501731873,
-0.025257721543312073,
0.0009150190744549036,
-0.014198140241205692,
-0.02725488878786564,
0.006481005810201168,
-0.0012031332589685917,
0.009769156575202942,
0.009265448898077011,
0.014632835984230042,
-0.013361824676394463,
0.002639241050928831,
0.0017162059666588902,
0.01384070422500372,
-0.02627864107489586,
0.008802050724625587,
-0.020033348351716995,
0.01840929687023163,
0.014121292158961296,
-0.015437040477991104,
-0.00441356748342514,
0.0058213407173752785,
-0.009877121075987816,
0.00590053666383028,
0.001300858799368143,
-0.017287464812397957,
0.03654803708195686,
-0.029791712760925293,
-0.0029086899012327194,
0.021486300975084305,
0.0028580552898347378,
0.002567254239693284,
0.00834733061492443,
0.0009872843511402607,
0.026207102462649345,
-0.017764288932085037,
0.03284265846014023,
0.01950261741876602,
0.008803073316812515,
0.0010366560891270638,
0.016786664724349976,
0.006890724413096905,
-0.001486771972849965,
-0.00914575532078743,
-0.08144332468509674,
-0.007451261859387159,
-0.01621202379465103,
0.006042678840458393,
0.005828171968460083,
0.00831248052418232,
0.01730165258049965,
-0.0023122644051909447,
-0.007649129722267389,
0.0032121518161147833,
0.001307095866650343,
0.018161693587899208,
-0.01043902151286602,
0.00316653773188591,
-0.03703149035573006,
-0.006069552153348923,
0.01482497900724411,
-0.025448672473430634,
0.006246297620236874,
-0.036535803228616714,
0.01674620807170868,
-0.0209841039031744,
0.015797825530171394,
0.0048193600960075855,
0.0025324802845716476,
0.017022989690303802,
0.016278408467769623,
0.017051614820957184,
-0.018227435648441315,
-0.005802502389997244,
-0.013087144121527672,
0.017427541315555573,
-0.0002321463543921709,
0.016631439328193665,
-0.014723634347319603,
-0.001199063379317522,
0.007357128895819187,
0.013006852939724922,
-0.0013078227639198303,
0.018084509298205376,
-0.027456676587462425,
-0.00351698137819767,
0.0032575996592640877,
-0.0020215343683958054,
0.006117395590990782,
0.0052753034979105,
-0.005805688444525003,
0.01864001899957657,
0.018506115302443504,
-0.018227722495794296,
0.00352125009521842,
0.009320484474301338,
0.010280879214406013,
0.021463606506586075,
-0.01960710436105728,
-0.016278531402349472,
-0.012230298481881618,
0.007737112697213888,
-0.009502009488642216,
-0.01318715512752533,
0.022846095263957977,
-0.00923979002982378,
0.031066540628671646,
0.010076737962663174,
-0.02016700990498066,
-0.01037124264985323,
0.0059519317001104355,
0.001942864153534174,
-0.014738778583705425,
0.004905549809336662,
0.003568594343960285,
0.005418964195996523,
0.00538204750046134,
-0.004202890209853649,
-0.0015078829601407051,
-0.00984552875161171,
-0.010952362790703773,
-0.0081402026116848,
0.02921360358595848,
-0.013024041429162025,
-0.010765202343463898,
0.0036627077497541904,
0.0008721393533051014,
0.011486969888210297,
-0.012443449348211288,
-0.0013867935631424189,
0.0012097471626475453,
0.024732178077101707,
0.013659661635756493,
-0.008018223568797112,
0.005192062817513943,
-0.00012730201706290245,
-0.0067462008446455,
0.009912358596920967,
-0.018119104206562042,
-0.0160771943628788,
-0.0070770918391644955,
-0.005457526538521051,
0.020380087196826935,
0.006049056071788073,
-0.024713784456253052,
-0.0054378448985517025,
-0.006853051949292421,
-0.015059476718306541,
-0.01452597975730896,
0.01358475349843502,
0.00166338961571455,
-0.0219012051820755,
-0.02103498764336109,
-0.000023042724933475256,
-0.011502306908369064,
-0.01143454946577549,
-0.010985921137034893,
0.025391725823283195,
0.009908504784107208,
0.04087845981121063,
-0.0010949261486530304,
-0.02020828053355217,
0.07254405319690704,
-0.009217910468578339,
0.00023715011775493622,
-0.023076433688402176,
0.007311901077628136,
-0.016529498621821404,
-0.005252454895526171,
0.018789218738675117,
-0.010648312978446484,
0.0007165367715060711,
0.009632891044020653,
0.019625872373580933,
0.006864259950816631,
0.009946189820766449,
-0.008023086935281754,
0.023769093677401543,
0.0013819464948028326,
-0.0029216837137937546,
0.025596629828214645,
0.009932460263371468,
0.01764533855021,
-0.012778696604073048,
-0.006987825036048889,
0.002497036475688219,
0.0025060498155653477,
-0.02022763155400753,
-0.025644510984420776,
-0.01290002092719078,
-0.005224298685789108,
0.01102253794670105,
0.004633029457181692,
-0.021738825365900993,
-0.00931619480252266,
-0.002244670409709215,
0.03248408064246178,
0.01828688010573387,
0.00875540729612112,
-0.01259533129632473,
0.014226347208023071,
-0.0017595182871446013,
-0.04094555228948593,
-0.014186346903443336,
0.00683475099503994,
-0.0012564841890707612,
-0.021001890301704407,
-0.01879258267581463,
0.012779982760548592,
-0.008853917941451073,
0.0018392544006928802,
-0.010057879611849785,
-0.01037861779332161,
0.002433144487440586,
0.010158831253647804,
0.007106732577085495,
-0.0026465896517038345,
0.006162814795970917,
0.012446305714547634,
0.000618241960182786,
0.014862380921840668,
-0.006622252520173788,
-0.004409973509609699,
-0.0006302094552665949,
0.00763359572738409,
-0.011644283309578896,
0.01105591282248497,
-0.020539872348308563,
0.0017163618467748165,
0.0026136995293200016,
0.030509337782859802,
-0.025174813345074654,
-0.021568063646554947,
0.01101984828710556,
-0.016902249306440353,
-0.008763863705098629,
-0.012001490220427513,
0.02734515629708767,
-0.008989355526864529,
-0.0019029019167646766,
0.023122312501072884,
0.014123624190688133,
-0.03756657987833023,
0.016423862427473068,
0.005989063065499067,
-0.02783844992518425,
0.03050263039767742,
-0.008660133928060532,
-0.03679008409380913,
-0.0751347541809082,
-0.01804136112332344,
0.005120173096656799,
-0.004486351273953915,
-0.0030758108478039503,
0.006653310731053352,
-0.02423003315925598,
0.0063593038357794285,
0.00802411325275898,
0.002918592654168606,
0.02367420122027397,
-0.00490027479827404,
0.010047320276498795,
-0.017119742929935455,
0.010601047426462173,
0.012301599606871605,
0.014856697991490364,
-0.0015476641710847616,
-0.02074424922466278,
0.006215138826519251,
-0.007929759100079536,
0.010157276876270771,
-0.00918588787317276,
-0.014927977696061134,
-0.01207547914236784,
-0.08132851123809814,
-0.001831705216318369,
-0.0029392773285508156,
0.002263306640088558,
-0.0068542249500751495,
-0.0039379713125526905,
0.031170789152383804,
0.0042562782764434814,
-0.021753396838903427,
-0.011877940967679024,
-0.001591866952367127,
-0.01437227800488472,
-0.027346380054950714,
-0.0014883242547512054,
-0.012822825461626053,
-0.009905511513352394,
0.004846394993364811,
-0.00068266736343503,
-0.0028469092212617397,
-0.0077625298872590065,
-0.02280176244676113,
0.0002017216756939888,
-0.004997180309146643,
-0.020025018602609634,
-0.004836287349462509,
-0.007412335369735956,
-0.01302832830697298,
0.019249843433499336,
-0.003997516352683306,
-0.008663587272167206,
-0.012741603888571262,
-0.0252495426684618,
-0.021244045346975327,
0.004955691285431385,
-0.020196333527565002,
-0.011448590084910393,
-0.0029496944043785334,
-0.012707207351922989,
-0.0002245865180157125,
-0.004833800718188286,
-0.003574969479814172,
0.010639116168022156,
-0.016151264309883118,
0.007694235071539879,
-0.010687466710805893,
0.0023431084118783474,
0.005774528253823519,
-0.008215190842747688,
0.007634203881025314,
0.005115763749927282,
0.007232318166643381,
-0.018406229093670845,
-0.00036051636561751366,
0.00757523812353611,
0.019173435866832733,
0.006730481516569853,
-0.012063363566994667,
0.02177654579281807,
0.000055481214076280594,
0.012747621163725853,
0.007596028968691826,
0.015920579433441162,
-0.003542279824614525,
0.07196607440710068,
-0.022561579942703247,
0.023936256766319275,
-0.017620334401726723,
-0.009987764991819859,
0.006591241806745529,
-0.011952368542551994,
0.0023165142629295588,
-0.023757707327604294,
0.0004948521964251995,
0.033753901720047,
-0.010352413170039654,
0.02973499335348606,
0.011959612369537354,
-0.03227061778306961,
0.0075646257027983665,
0.00760933943092823,
-0.0005445510614663363,
0.0028199832886457443,
-0.005088347941637039,
0.0006326003931462765,
0.006576106883585453,
-0.01981063187122345,
-0.006547234486788511,
0.009078898467123508,
-0.007518591359257698,
-0.03160747513175011,
-0.013624252751469612,
-0.03205765038728714,
0.0044533442705869675,
-0.0005425845738500357,
-0.0013525085523724556,
0.0009120795875787735,
0.0007505200337618589,
0.00867824163287878,
0.010143542662262917,
-0.015750812366604805,
0.01816500350832939,
-0.002910766750574112,
-0.036581333726644516,
0.0074854097329080105,
0.017869984731078148,
-0.00024010572815313935,
0.0065191928297281265,
0.001449701376259327,
-0.023993220180273056,
-0.011645780876278877,
0.012916523031890392,
-0.009190943092107773,
-0.004487945698201656,
0.008847815915942192,
-0.0015259284991770983,
0.0029545819852501154,
0.004385175183415413,
-0.0026716673746705055,
-0.00007149204611778259,
-0.01718137040734291,
-0.0010584848932921886,
0.007467391900718212,
-0.002494231564924121,
0.015143570490181446,
-0.0028250725008547306,
0.008293666876852512,
-0.00516930827870965,
0.014038019813597202,
0.022735197097063065,
0.028585828840732574,
-0.014438608661293983,
0.0020153261721134186,
0.015549859032034874,
-0.012711829505860806,
0.011650130152702332,
0.008490470238029957,
0.0070954058319330215,
0.01639566570520401,
0.007281293161213398,
0.014575935900211334,
0.0019075069576501846,
0.006466745864599943,
0.009058880619704723,
-0.008455948904156685,
-0.006313883233815432,
0.0007621424738317728,
0.010267088189721107,
-0.014285238459706306,
0.006952243857085705,
0.02644706331193447,
0.023185105994343758,
0.0033278311602771282,
0.009903941303491592,
0.004250390455126762,
0.004471811931580305,
0.0015650478890165687,
0.009263602085411549,
0.00800425186753273,
0.03204696625471115,
0.030940305441617966,
-0.00010092812590301037,
-0.023770740255713463,
0.010338813997805119,
0.016344565898180008,
0.003265757579356432,
-0.0114310747012496,
-0.014328681863844395,
-0.005312168039381504,
0.007770157419145107,
0.006301445886492729,
0.01923668012022972,
-0.006718763615936041,
0.04513532668352127,
-0.0008673615520820022,
-0.026227526366710663,
0.0015306570567190647,
0.016450783237814903,
0.0018966958159580827,
-0.0007442928617820144,
0.001711607095785439,
0.03348740190267563,
-0.007863424718379974,
-0.015993213281035423,
0.0038413871079683304,
0.004639912396669388,
-0.017804786562919617,
0.02295224741101265,
0.02880854159593582,
-0.012288003228604794,
-0.014143871143460274,
0.022166835144162178,
-0.005085792392492294,
-0.006419180892407894,
0.020735831931233406,
0.010593224316835403,
-0.015684377402067184,
0.01617463305592537,
0.004041322506964207,
0.005280922167003155,
0.00044483039528131485,
0.024709206074476242,
-0.013562574982643127,
0.00043301191180944443,
0.005914032459259033,
-0.028533976525068283,
0.0030435342341661453,
-0.0069881402887403965,
0.007715965621173382,
0.006130123045295477,
0.006637789309024811,
0.01658455654978752,
-0.002048272406682372,
-0.016961300745606422,
0.013620034791529179,
0.007776747457683086,
-0.005340874660760164,
-0.010554669424891472,
0.017327487468719482,
0.019938796758651733,
0.0005437671206891537,
-0.0028079403564333916,
0.0065371328964829445,
0.013900341466069221,
-0.009076906368136406,
-0.03583540394902229,
-0.016250640153884888,
0.009850484319031239,
0.010458569973707199,
0.009496951475739479,
-0.009385908022522926,
0.012126965448260307,
-0.02197437919676304,
-0.028325622901320457,
0.03887610137462616,
0.005375690758228302,
-0.013736449182033539,
0.011408504098653793,
-0.04139799624681473,
0.016084400936961174,
0.008931866846978664,
-0.0024982523173093796,
-0.005373969674110413,
0.011752044782042503,
-0.004096074029803276,
-0.01154998503625393,
0.013988303020596504,
-0.005863951984792948,
0.002107716631144285,
0.002485845237970352,
-0.010341046378016472,
0.006123385392129421,
0.002913723001256585,
-0.009889712557196617,
-0.01991342380642891,
0.0013753389939665794,
-0.005255375523120165,
0.005802260711789131,
0.012066693976521492,
0.006397619377821684,
0.03535623848438263,
0.02550903894007206,
0.015122031792998314,
-0.012681425549089909,
0.002656335011124611,
-0.02742103487253189
] | [
-0.012930699624121189,
0.049252357333898544,
0.40818628668785095,
0.20221497118473053,
-0.16907180845737457,
-0.2188921868801117,
0.12423114478588104,
-0.9237949252128601,
-0.05094386264681816,
0.029286736622452736,
0.03977404534816742,
0.27071788907051086,
-0.1759508103132248,
0.11205260455608368,
0.20759643614292145,
0.7762746214866638,
0.6448370814323425,
0.13793304562568665,
0.11178997159004211,
-1.1608387231826782,
0.2424749881029129,
-0.2826439440250397,
0.4486543536186218,
-0.18917886912822723,
0.23715142905712128,
0.4271806478500366,
0.3857027590274811,
-0.29601213335990906,
0.6087783575057983,
-0.18341225385665894,
-0.018717538565397263,
0.6404926776885986,
0.07214143127202988,
-0.15730734169483185,
0.22664619982242584,
-0.06012779474258423,
-0.584440290927887,
0.20492251217365265,
-0.02633647993206978,
-0.33246469497680664,
-0.2149212807416916,
-0.12349533289670944,
-0.5521050095558167,
0.6048984527587891,
0.25289133191108704,
0.0913049653172493,
-1.4524236917495728,
0.33133748173713684,
-0.2728028893470764,
-0.2747420072555542,
0.013034500181674957,
0.48910456895828247,
0.342706561088562,
-0.026196878403425217,
0.2934318482875824,
0.494752436876297,
-0.7285677790641785,
-0.36800962686538696,
0.4265846610069275,
-0.23508046567440033,
-0.33670103549957275,
-0.07682808488607407,
-0.4175310432910919,
0.29981788992881775,
-0.04552466422319412,
0.6246871948242188,
-0.15845559537410736,
0.07004361599683762,
-0.17476758360862732,
0.00823844876140356,
0.5280787348747253,
-0.32097670435905457,
0.04149682819843292,
0.24118423461914062,
0.0071051702834665775,
-0.36368560791015625,
-0.17725887894630432,
-0.15927909314632416,
0.4799344539642334,
0.42557501792907715,
0.08340561389923096,
-0.29259562492370605,
0.06363038718700409,
0.02767791412770748,
0.5321142673492432,
0.1833285093307495,
-0.0357074998319149,
0.3191487789154053,
-0.9209096431732178,
0.11577776819467545,
-0.07198306918144226,
-0.17590515315532684,
0.523451030254364,
0.2852226793766022,
0.06656796485185623,
0.4073426425457001,
-0.502933919429779,
-0.018253397196531296,
-0.009985184296965599,
0.3885416090488434,
-0.3809871971607208,
0.20635206997394562,
-0.7429496049880981,
-0.2996058166027069,
-0.3865111470222473,
-0.06916835904121399,
-0.4333348572254181,
-0.9305878281593323,
-0.7748358845710754,
0.22961068153381348,
-0.32899004220962524,
-0.25159165263175964,
-0.6628912687301636,
0.08161473274230957,
0.023710988461971283,
0.3112978935241699,
0.20960992574691772,
-0.19953300058841705,
0.2946775257587433,
0.469546914100647,
-0.033355243504047394,
1.2468363046646118,
-0.34095728397369385,
0.5206099152565002,
0.16072382032871246,
-0.00641891872510314,
0.469927042722702,
0.29393118619918823,
0.06535141170024872,
0.6285262107849121,
0.1599143147468567,
0.8486775755882263,
-0.3277805745601654,
-0.14730452001094818,
-0.08586622774600983,
-0.13369467854499817,
-0.06232983618974686,
0.08307921886444092,
-0.12340913712978363,
0.4641416370868683,
0.017182987183332443,
-0.5379340648651123,
0.09872917830944061,
-0.030531900003552437,
-0.005007240921258926,
-0.06626412272453308,
-0.1456419974565506,
0.11082598567008972,
-0.24799032509326935,
-0.013633252121508121,
-0.17974154651165009,
-0.008772416971623898,
-0.30783969163894653,
0.025977374985814095,
-0.16885125637054443,
0.41357144713401794,
-0.45187798142433167,
0.14395564794540405,
-0.1181042343378067,
0.11909755319356918,
0.058037422597408295,
0.04440772905945778,
-0.5878930687904358,
-0.2627142369747162,
0.6604317426681519,
0.06860002875328064,
0.41750001907348633,
0.12510287761688232,
-0.07460711896419525,
-0.20372655987739563,
-0.46703672409057617,
-0.6869010925292969,
-0.220653235912323,
-0.37456178665161133,
-0.03506441041827202,
-0.2058405727148056,
0.6403692960739136,
-0.37157315015792847,
0.06542452424764633,
0.058191929012537,
-0.8697049617767334,
-0.04019157215952873,
-0.6215512156486511,
-1.0207977294921875,
0.41866055130958557,
0.5315199494361877,
0.6709281206130981,
0.3019122779369354,
0.10150729864835739,
0.5114103555679321,
0.07674307376146317,
0.1256536990404129,
1.0381473302841187,
-0.5071845054626465,
1.5850372314453125,
-0.12283895164728165,
0.11731921881437302,
0.7889018058776855,
-0.0004278566921129823,
0.050749771296978,
-0.14667925238609314,
0.23713552951812744,
0.483657568693161,
-0.41854414343833923,
-0.5852715373039246,
-0.21795372664928436,
0.02232988178730011,
-0.26905274391174316,
-0.08714959770441055,
0.1108298972249031,
0.17693930864334106,
-0.10318485647439957,
-0.19888779520988464,
-0.33751222491264343,
0.13156744837760925,
-0.2609168589115143,
0.38335156440734863,
0.20686964690685272,
-0.07643686980009079,
0.299238383769989,
0.5318298935890198,
-0.5306273102760315,
0.6313884258270264,
0.9757960438728333,
-0.6023461222648621,
0.8074449896812439,
0.37349390983581543,
0.2688907980918884,
0.47921961545944214,
-0.17239028215408325,
0.22281773388385773,
-0.16203109920024872,
0.37109923362731934,
-0.4735405147075653,
0.032734230160713196,
0.06131167709827423,
0.010552085004746914,
-0.2373734712600708,
0.2959744334220886,
-0.13288702070713043,
0.0358784981071949,
0.5118893980979919,
-0.1906333714723587,
-0.14226609468460083,
0.32862862944602966,
-0.38684362173080444,
-0.3380427062511444,
0.38245952129364014,
-0.5820128917694092,
-0.2742733359336853,
0.16721133887767792,
0.28470590710639954,
0.289246141910553,
-0.4393712878227234,
-0.09323220700025558,
0.19158080220222473,
-0.33258965611457825,
-0.4649532437324524,
-0.05739309638738632,
-0.08051842451095581,
-0.34636205434799194,
-0.1602240949869156,
0.051785457879304886,
0.1318100541830063,
0.280921071767807,
-0.0815412625670433,
-0.4194103181362152,
-0.274829238653183,
0.9903101325035095,
0.5165261626243591,
0.3794211745262146,
-0.21891635656356812,
-0.5763415694236755,
-0.09101492911577225,
-0.07358168810606003,
-0.7129851579666138,
0.00369324441999197,
0.8300150036811829,
-0.07099597901105881,
-0.5691666007041931,
-0.190300852060318,
0.36372753977775574,
0.7507941722869873,
-0.14667090773582458,
-0.24627698957920074,
0.1502498835325241,
-0.4209151566028595,
-0.5156152248382568,
-0.6283287405967712,
-0.47599300742149353,
0.06166082248091698,
0.30741608142852783,
-0.3322990834712982,
-0.20088347792625427,
0.37580984830856323,
0.21726565062999725,
-0.29722627997398376,
0.4352763593196869,
0.734760046005249,
0.3799887001514435,
-0.07632583379745483,
0.2906776964664459,
-0.49235570430755615,
-0.1495571881532669,
-0.22697597742080688,
-0.10543528199195862,
-0.2992500960826874,
0.14168091118335724,
-5.860590934753418,
0.1810338944196701,
-0.3975602984428406,
0.004658568650484085,
-0.12184856086969376,
-0.1458582878112793,
1.0497965812683105,
0.059996284544467926,
0.17287549376487732,
0.21420840919017792,
0.07496462762355804,
0.47294938564300537,
0.06704166531562805,
-0.041664618998765945,
0.096164271235466,
0.34512457251548767,
-0.11738964915275574,
-0.45978617668151855,
0.9736639261245728,
-0.01065859105437994,
0.3563201129436493,
-0.09732341766357422,
-0.005532655864953995,
0.2051333785057068,
0.33932435512542725,
-0.6288235783576965,
-1.1110857725143433,
0.49070557951927185,
-0.2157016098499298,
0.0621420219540596,
0.43038326501846313,
-0.5173532366752625,
-0.4079224169254303,
-0.12163299322128296,
0.18477652966976166,
0.011176145635545254,
0.47612524032592773,
-0.06541136652231216,
-0.15161438286304474,
-0.2965134382247925,
0.6390634179115295,
0.1550854742527008,
-0.18123888969421387,
-0.023484306409955025,
0.42564070224761963,
-0.12892073392868042,
-0.037920765578746796,
0.20415249466896057,
-0.2554629445075989,
0.3907276690006256,
-0.27831968665122986,
-0.17345823347568512,
0.3010818362236023,
0.559169590473175,
0.21187105774879456,
-0.2493644505739212,
-0.3267773985862732,
0.4076763093471527,
-0.6168134808540344,
0.5216483473777771,
-0.22104254364967346,
-0.07892001420259476,
-0.4366602301597595,
-0.6392316818237305,
0.04355375096201897,
0.38098660111427307,
-0.7398622035980225,
-0.42303964495658875,
0.003594914684072137,
-0.12285956740379333,
-0.19801633059978485,
0.28238219022750854,
0.1299847513437271,
-0.8028015494346619,
0.6991276741027832,
-0.35363975167274475,
0.38586360216140747,
0.3678158223628998,
-0.29094889760017395,
0.17753809690475464,
-0.04047175869345665,
-0.10858940333127975,
-0.025942273437976837,
-0.02675338089466095,
0.3729005455970764,
-0.35652557015419006,
0.06558362394571304,
-0.18507246673107147,
-0.00992403645068407,
0.4009844958782196,
0.4225686192512512,
-0.33030855655670166,
0.15519146621227264,
0.652458906173706,
-0.24364487826824188,
0.0786304697394371,
0.3383505642414093,
0.20778055489063263,
0.2715151906013489,
-0.1488301157951355,
0.8964220285415649,
0.11657050997018814,
-0.6001965403556824,
-0.890930712223053,
-0.2201506346464157,
0.1134338527917862,
-0.7269725799560547,
-0.26538291573524475,
0.7608158588409424,
-0.41219562292099,
0.08480177074670792,
-0.016345448791980743,
-0.1632837951183319,
0.12283435463905334,
0.6959192156791687,
-0.10015103220939636,
-0.385600209236145,
-0.22834694385528564,
0.4811558425426483,
-0.35145169496536255,
0.20128095149993896,
0.5674224495887756,
-0.4510731101036072,
0.34728386998176575,
-0.4507600665092468,
-0.53636234998703,
0.21149607002735138,
0.6864151954650879,
-0.8046990633010864,
0.02787279151380062,
0.32412347197532654,
0.40637391805648804,
-0.7411459684371948,
-0.24167323112487793,
0.3393579125404358,
-0.11715090274810791,
-0.5232968926429749,
0.16396814584732056,
0.48542800545692444,
0.08344624191522598,
0.4860652685165405,
-0.45338311791419983,
0.09798353910446167,
0.32348909974098206,
0.2913856506347656,
0.02688644453883171,
0.24247565865516663,
0.22451256215572357,
-0.4670104384422302,
-0.014178658835589886,
-0.09043442457914352,
-0.05892178416252136,
0.14736633002758026,
0.2538490891456604,
-0.15899235010147095,
0.2680501639842987,
0.6473214626312256,
0.1606258898973465,
0.368557333946228,
-0.18097242712974548,
0.4503755271434784,
0.5480431318283081,
-0.8925132751464844,
-0.2260589897632599,
0.20685860514640808,
-0.674091100692749,
-0.37202098965644836,
-0.149111807346344,
-0.23499789834022522,
0.0651550367474556,
-0.16908518970012665,
-0.3917331099510193,
-0.14857549965381622,
-0.02924707531929016,
0.0962778702378273,
0.34002962708473206,
-0.34128665924072266,
-0.01472415216267109,
-0.08046461641788483,
0.21150170266628265,
0.06689531356096268,
-0.8980314135551453,
-0.13084416091442108,
0.3558126389980316,
0.9050469994544983,
0.180482417345047,
-0.12808364629745483,
-0.19555850327014923,
-0.20012205839157104,
-0.27458903193473816,
0.11861305683851242,
0.07025972753763199,
0.6366597414016724,
0.3164505064487457,
0.007711405400186777,
-0.2916859984397888,
0.2503707706928253,
0.6850508451461792,
-0.29230666160583496,
-0.9651011824607849,
-0.04596443846821785,
0.9099828600883484,
0.03792085871100426,
0.4913472831249237,
0.4044150710105896,
-0.19014142453670502,
-0.3297586441040039,
-0.02011941932141781,
0.14737044274806976,
-0.11167693883180618,
0.03367050737142563,
-0.9216352105140686,
0.22061632573604584,
0.08580558747053146,
-0.3315959870815277,
0.06683700531721115,
0.3945469856262207,
-0.03772486001253128,
-0.41941747069358826,
0.12459424138069153,
-0.003777620382606983,
-0.13369354605674744,
-0.19257161021232605,
-0.26171743869781494,
-0.8429594039916992,
0.04036526381969452,
0.4090355634689331,
-0.9154543280601501,
0.2067146748304367,
0.28646737337112427,
-0.0930708572268486,
-0.21343526244163513,
0.04711456969380379,
-0.23533666133880615,
-0.4509110152721405,
-0.5465992093086243,
-0.7027824521064758,
0.3448046147823334,
-0.09741928428411484,
0.35329321026802063,
-0.33698078989982605,
0.00209742970764637,
-0.020565710961818695,
-0.22193734347820282,
-0.0241126399487257,
0.13311275839805603,
0.4964728355407715,
-0.2538049817085266,
-0.3295438587665558,
-0.2394934445619583,
0.1708465963602066,
-0.06480954587459564,
0.3412599265575409,
0.2277151495218277,
1.1826138496398926,
0.13030578196048737,
-0.12794841825962067,
-0.3592784106731415,
-0.16521604359149933,
0.25685515999794006,
-0.35939082503318787,
0.14144054055213928,
-0.47482556104660034,
-0.3836827874183655,
0.12685851752758026,
0.009821386076509953,
-0.008669937029480934,
-0.7487711906433105,
0.1482166349887848,
-0.23296649754047394,
-0.41865137219429016,
-0.026186201721429825,
0.5859292149543762,
0.43418046832084656,
0.013830195181071758,
0.3028755187988281,
-0.5211392641067505,
0.03526807576417923,
0.1814456284046173,
0.34521302580833435,
-0.18705418705940247,
-0.3548053801059723,
0.2540816366672516,
-0.18479374051094055,
0.3346412777900696,
-0.5225338935852051,
-0.2218858003616333,
-0.3636288046836853,
0.26048707962036133,
-0.0039038921240717173,
-0.20493321120738983,
0.2908259928226471,
-0.9885655045509338,
-0.3643258810043335,
-0.1098853349685669,
0.2359287142753601,
0.07848062366247177,
-0.0057989018969237804,
-0.027716487646102905,
0.04183431714773178,
-0.2558981478214264,
0.6495550274848938,
0.8441696166992188,
-0.45439764857292175,
-0.20058463513851166,
0.49407246708869934,
0.37634387612342834,
0.04367414489388466,
-0.277662456035614,
-0.14513064920902252,
-0.20970654487609863,
-0.1271791011095047,
0.5431342124938965,
-0.3748362064361572,
-0.6988025903701782,
0.1229887306690216,
-0.10641804337501526,
-0.0032315256539732218,
0.0337027870118618,
-0.06830711662769318,
0.5034329295158386,
1.014150619506836,
0.47500044107437134,
-0.052290674299001694,
-0.4859028160572052,
0.3891352713108063,
-0.1462579220533371,
-0.05834168195724487,
-0.2979397773742676,
0.33680251240730286,
0.7153573036193848,
0.09045320004224777,
-0.34708625078201294,
0.40087828040122986,
0.23608607053756714,
0.9248957633972168,
-0.11809675395488739,
-0.12079665809869766,
-0.3769509196281433,
0.20333321392536163,
0.2976287603378296,
0.48143085837364197,
-0.5119296312332153,
-0.23049437999725342,
-0.24007190763950348,
0.3394201099872589,
0.17544810473918915,
-0.22239217162132263,
-0.12159742414951324,
0.499335914850235,
0.02209540642797947,
0.12526729702949524,
-0.5034757852554321,
-0.11424962431192398,
-1.0001230239868164,
0.05495515838265419,
0.2189081460237503,
-0.09706921130418777,
-0.40975162386894226,
0.14179293811321259,
0.05148724094033241,
0.21772068738937378,
0.051146019250154495,
0.9371927380561829,
-0.5895797610282898,
0.23129163682460785,
0.38711172342300415,
0.2676233649253845,
0.31364816427230835,
0.1766163557767868,
-0.4105500280857086,
0.024297993630170822,
-0.09270022809505463,
0.3504769802093506,
-0.019778767600655556,
-0.7087664604187012,
-0.14278315007686615,
-0.4381696581840515,
-0.2430611401796341,
0.3607662618160248,
-0.28926777839660645,
0.18904291093349457,
-0.5866890549659729,
-0.6192129254341125,
0.026115426793694496,
-0.3918493390083313,
-0.2645720839500427,
-0.12108808755874634,
-0.09749487787485123,
-0.09060174226760864,
0.09936675429344177,
-0.5654110312461853,
0.23559604585170746,
0.2734096348285675,
-0.14630454778671265,
0.14483466744422913,
0.07737253606319427,
0.39806610345840454,
0.290740966796875,
0.7760928273200989,
-0.2923862040042877,
0.1385543942451477,
-0.10479844361543655,
0.652894139289856,
-0.46140846610069275,
0.5613741278648376,
-0.6953029632568359,
-0.09401611983776093,
-0.4759388864040375,
-0.46626630425453186,
0.8721109628677368,
0.590589702129364,
-0.08375012874603271,
-0.13457146286964417,
0.19741098582744598,
0.2731023132801056,
0.353853702545166,
-0.663705587387085,
-0.06422558426856995,
-0.22051559388637543,
-0.5678678750991821,
-0.7273513674736023,
0.6552627682685852,
0.15104585886001587,
-0.3956848382949829,
-0.15867801010608673,
0.5719779133796692,
-0.08306269347667694,
0.08586882799863815,
0.2719254195690155,
-0.028556229546666145,
-0.2553059756755829,
-0.6813347339630127,
0.5032047629356384,
-0.14741180837154388,
0.22925421595573425,
-0.2919981777667999,
0.3304155170917511,
0.16149745881557465,
0.3445826768875122,
-0.2093460112810135,
-0.048768360167741776,
-0.03336876630783081,
0.1668558269739151,
-0.16492721438407898,
0.25364768505096436,
-0.1916152834892273,
-1.0844024419784546,
-0.9104077816009521,
0.06827613711357117,
0.0945071280002594,
-0.24303705990314484,
-0.27296701073646545,
-0.1483144313097,
0.1197371706366539,
0.14061391353607178,
-0.009310170076787472,
-0.44810259342193604,
-0.2510494291782379,
-0.07518666982650757
] |
© Joanna Moncrieff 2013. All rights reserved. A challenging reappraisal of the history of antipsychotics, revealing how they were transformed from neurological poisons into magical cures, their benefits exaggerated and their toxic effects minimized or ignored. | [
0.03203805908560753,
0.000688308326061815,
-0.0035256838891655207,
0.008829168044030666,
-0.015390804968774319,
0.00958375632762909,
0.013408532366156578,
0.021259035915136337,
-0.02847272902727127,
-0.025207437574863434,
-0.017785869538784027,
0.015614394098520279,
-0.01465818751603365,
-0.014081102795898914,
0.000006479073817899916,
-0.02510973811149597,
-0.017240582033991814,
0.045398615300655365,
0.017803512513637543,
0.0071685765869915485,
0.0040283286944031715,
-0.005006864201277494,
0.013574096374213696,
-0.022847341373562813,
0.0008982928120531142,
0.04348669573664665,
-0.01677924022078514,
-0.012540297582745552,
0.007817677222192287,
-0.0021267684642225504,
-0.009693723171949387,
0.015683721750974655,
0.038861438632011414,
0.016064606606960297,
0.0032393247820436954,
0.02719665691256523,
0.004848673474043608,
0.017315683886408806,
0.0320882648229599,
-0.004718695301562548,
0.04713006317615509,
-0.009452556259930134,
0.005097644869238138,
-0.006384786684066057,
-0.011778672225773335,
0.006799289956688881,
-0.0009945955825969577,
0.0384371392428875,
-0.009591849520802498,
0.006786422338336706,
-0.005202044267207384,
-0.028825795277953148,
-0.017680425196886063,
-0.026562845334410667,
-0.008478943258523941,
-0.024380188435316086,
0.025665054097771645,
0.003885232610628009,
0.006007366348057985,
-0.009268764406442642,
0.01361592672765255,
0.02022452838718891,
0.003891262924298644,
0.015296650119125843,
0.024817902594804764,
-0.0654187798500061,
-0.0016569277504459023,
0.06397942453622818,
-0.00970219261944294,
0.04180091992020607,
0.019222525879740715,
0.028468316420912743,
-0.023183854296803474,
-0.024521417915821075,
-0.003823978826403618,
0.016641264781355858,
-0.0006709718145430088,
0.04241307079792023,
0.00936072412878275,
0.0631914883852005,
-0.03134681656956673,
-0.024987831711769104,
0.013608292676508427,
0.017278026789426804,
-0.020107891410589218,
-0.002689432818442583,
-0.019561076536774635,
-0.021047933027148247,
-0.0011350685963407159,
0.022519249469041824,
-0.01969359628856182,
-0.0241030752658844,
-0.01862780749797821,
-0.01184077002108097,
0.05097983404994011,
0.018564654514193535,
-0.02944871410727501,
0.023285968229174614,
0.046021681278944016,
-0.028492648154497147,
-0.01898340694606304,
0.031182901933789253,
0.03282863274216652,
0.0028630602173507214,
-0.012385525740683079,
0.01624506525695324,
-0.024667764082551003,
0.011518132872879505,
-0.019117413088679314,
0.003908406477421522,
-0.01491151936352253,
-0.018963851034641266,
-0.028414800763130188,
0.008860760368406773,
-0.0048246984370052814,
0.030298933386802673,
0.045887354761362076,
-0.004193434026092291,
0.010659818537533283,
-0.0160989910364151,
0.04567345604300499,
-0.02650359459221363,
0.007249463349580765,
-0.016799984499812126,
0.005500581581145525,
0.0036246145609766245,
0.00282221008092165,
-0.0002806978009175509,
0.023150572553277016,
0.005515113938599825,
-0.011896539479494095,
0.0017092331545427442,
-0.0018715369515120983,
-0.03336580842733383,
0.011335687711834908,
-0.021929742768406868,
0.0024104714393615723,
0.0054994262754917145,
0.00014737040328327566,
-0.01617058552801609,
-0.0005505815497599542,
0.0034928442910313606,
-0.011413566768169403,
0.022635025903582573,
0.015553747303783894,
0.011320739053189754,
0.00253511150367558,
0.004442553035914898,
-0.02583167515695095,
-0.019327959045767784,
0.049211639910936356,
-0.015500927343964577,
0.008923947811126709,
0.0068216267973184586,
0.006860401947051287,
0.03891892358660698,
-0.02126522734761238,
-0.030399275943636894,
-0.014608258381485939,
0.010172701440751553,
-0.007893712259829044,
0.02096848376095295,
0.0009724673582240939,
0.011078977026045322,
0.004961142782121897,
-0.0017159831477329135,
0.03806446120142937,
-0.0020430523436516523,
-0.01343956496566534,
-0.006449365057051182,
-0.006921668536961079,
0.025390369817614555,
0.029567109420895576,
0.013121649622917175,
-0.01535816676914692,
0.0018239389173686504,
0.03019777312874794,
0.01263633742928505,
0.003911507781594992,
0.06577453017234802,
-0.010811357758939266,
0.03983461111783981,
0.022916998714208603,
-0.012877827510237694,
0.007677034940570593,
0.01067837979644537,
0.021675916388630867,
-0.0036055410746484995,
-0.04519510641694069,
0.031369004398584366,
-0.00227723503485322,
0.02069101855158806,
0.024300167337059975,
-0.009169324301183224,
0.020276809111237526,
0.006581501569598913,
0.0038313246332108974,
-0.003302579978480935,
-0.06232107803225517,
0.025826312601566315,
-0.004301039967685938,
-0.013463861308991909,
0.04547371715307236,
-0.02758857049047947,
0.00042161199962720275,
-0.018781419843435287,
-0.020102789625525475,
-0.029851431027054787,
0.035892654210329056,
0.004836682230234146,
0.020098017528653145,
0.011052158661186695,
0.01910230703651905,
-0.010004922747612,
0.041571423411369324,
-0.020141949877142906,
-0.04592302814126015,
0.01688583381474018,
-0.004037287551909685,
-0.028422243893146515,
-0.004456692840903997,
0.026268329471349716,
-0.01678178831934929,
0.013479792512953281,
-0.008789297193288803,
0.014102921821177006,
0.04882972314953804,
0.02231769636273384,
0.0411921888589859,
-0.00606553303077817,
-0.012374257668852806,
-0.009178875014185905,
-0.010243316181004047,
0.014887310564517975,
-0.03328404575586319,
0.013061567209661007,
0.019816361367702484,
0.01708521880209446,
0.011297118850052357,
-0.02343866042792797,
0.03825238719582558,
-0.022182393819093704,
-0.014544788748025894,
-0.01125849224627018,
0.048336710780858994,
-0.027272505685687065,
0.016947926953434944,
-0.010527295991778374,
-0.017899686470627785,
0.00656876852735877,
0.006503395736217499,
-0.010607324540615082,
0.026028327643871307,
0.001351612969301641,
-0.013285879045724869,
0.0046010566875338554,
-0.007342953234910965,
0.015645870938897133,
0.031206276267766953,
-0.006937001366168261,
0.01286726351827383,
-0.0012743644183501601,
0.002217736328020692,
-0.032088104635477066,
-0.05055723711848259,
0.03358018025755882,
0.025016237050294876,
-0.0226735919713974,
-0.007484102621674538,
0.018392112106084824,
0.006711849942803383,
-0.015618516132235527,
0.006707032211124897,
-0.0819329172372818,
-0.01915130391716957,
-0.003007688792422414,
0.06388460844755173,
0.025897888466715813,
0.01945752464234829,
-0.012279469519853592,
0.00240269280038774,
-0.032734617590904236,
-0.0013976359041407704,
-0.037930283695459366,
0.010691473260521889,
-0.018509840592741966,
0.025770001113414764,
-0.0068938229233026505,
0.0016142777167260647,
0.003344866679981351,
-0.0012038027634844184,
-0.03033704310655594,
-0.026714615523815155,
-0.0016222854610532522,
-0.0012368232710286975,
0.0045060086995363235,
-0.018841028213500977,
-0.0003635617031250149,
0.010646184906363487,
0.014416653662919998,
0.0076310522854328156,
-0.025416985154151917,
0.03528216853737831,
-0.009791326709091663,
-0.02046063356101513,
-0.0139353321865201,
-0.005439062602818012,
0.026664065197110176,
0.02850368060171604,
-0.009385999292135239,
-0.0032933412585407495,
-0.027452997863292694,
-0.0043883793987333775,
-0.011884000152349472,
0.006302032619714737,
0.03777841106057167,
-0.010573923587799072,
0.026659922674298286,
0.005844519939273596,
0.002610622439533472,
-0.011047241277992725,
-0.0015286618145182729,
0.009974674321711063,
-0.013407195918262005,
0.01605181023478508,
-0.00620524026453495,
0.015331272967159748,
-0.013221013359725475,
-0.023449135944247246,
-0.015534553676843643,
0.022795051336288452,
-0.015272000804543495,
0.012717378325760365,
-0.05397353321313858,
0.01592647284269333,
0.004112491384148598,
-0.013131089508533478,
-0.01268688589334488,
0.011929125525057316,
0.023233776912093163,
-0.034319113940000534,
-0.018157612532377243,
0.027302639558911324,
0.01811067759990692,
-0.017885703593492508,
-0.01454776618629694,
-0.004539241548627615,
0.04830005019903183,
-0.014222102239727974,
-0.017669368535280228,
0.0014706458896398544,
0.0050675105303525925,
-0.03608602657914162,
0.027737164869904518,
0.007479046005755663,
-0.018419256433844566,
-0.042481642216444016,
-0.00725391274318099,
-0.039548128843307495,
0.006129436660557985,
-0.026529531925916672,
0.012137452140450478,
-0.01926036737859249,
-0.08566950261592865,
-0.0006407186738215387,
-0.03855210915207863,
0.025413980707526207,
0.014325684867799282,
-0.014171922579407692,
0.0016441120533272624,
-0.0028694423381239176,
-0.007423379458487034,
0.013998708687722683,
0.019419260323047638,
-0.0029600406996905804,
-0.02898780256509781,
-0.014615245163440704,
-0.02233375422656536,
0.00897253304719925,
0.0027155796997249126,
0.01501726359128952,
-0.007708736229687929,
-0.01260251086205244,
0.010420716367661953,
-0.04630931466817856,
-0.001527720014564693,
0.010912969708442688,
0.01286205556243658,
0.002690186258405447,
0.011235427111387253,
-0.011305434629321098,
0.06963779777288437,
0.027745284140110016,
0.011172558180987835,
0.001860253163613379,
0.015289261937141418,
-0.040898654609918594,
-0.01864578016102314,
0.011799437925219536,
-0.013190287165343761,
-0.018143553286790848,
0.01983937993645668,
0.016271118074655533,
-0.0025788936764001846,
0.044325485825538635,
0.02696513570845127,
-0.04735495522618294,
0.007925678044557571,
0.025852791965007782,
-0.006924774032086134,
0.03240728750824928,
0.04728144407272339,
-0.009584995917975903,
0.04828208312392235,
-0.0017641987651586533,
0.034660134464502335,
0.006007414776831865,
0.0292490404099226,
-0.01680375263094902,
0.03128223121166229,
0.010880233719944954,
-0.028681904077529907,
0.02393377758562565,
-0.006282018963247538,
0.0034624687395989895,
0.005060368683189154,
-0.024865031242370605,
0.008493775501847267,
0.012326276861131191,
-0.023856373503804207,
-0.0014552217908203602,
0.006219807080924511,
-0.008355863392353058,
-0.0015357881784439087,
0.026590215042233467,
-0.018799446523189545,
0.0034658864606171846,
0.006541174836456776,
-0.004570202901959419,
0.008275828324258327,
-0.0002968589833471924,
0.007982242852449417,
-0.001172875752672553,
0.010591305792331696,
-0.00099462759681046,
-0.0033675627782940865,
-0.009460982866585255,
-0.013607349246740341,
0.020619980990886688,
-0.014080001041293144,
-0.02830849401652813,
-0.03547004237771034,
0.03352588787674904,
0.004956940654665232,
0.024695854634046555,
-0.0008599442080594599,
-0.016013827174901962,
0.00027130322996526957,
0.0034008410293608904,
-0.02559589594602585,
-0.03073692135512829,
-0.010912815108895302,
0.016609612852334976,
0.01180777046829462,
0.013942275196313858,
-0.015092954970896244,
-0.017390955239534378,
-0.006983509287238121,
0.021012049168348312,
0.0030811496544629335,
0.021047959104180336,
-0.011730489321053028,
-0.003704627975821495,
-0.023302631452679634,
-0.015913788229227066,
-0.03672577068209648,
0.023083660751581192,
0.009787929244339466,
-0.07283575087785721,
-0.029769135639071465,
0.0152976606041193,
-0.006762954872101545,
-0.0251558106392622,
0.00513378344476223,
0.0013538694474846125,
0.030407648533582687,
0.010164686478674412,
0.021094998344779015,
-0.004195287358015776,
-0.025588300079107285,
0.026995263993740082,
0.019385403022170067,
0.016922954469919205,
0.03430590778589249,
-0.019108081236481667,
0.004589227959513664,
-0.01760121062397957,
-0.011835127137601376,
-0.0009336232324130833,
0.02933163195848465,
-0.03445393964648247,
0.00048739940393716097,
-0.012530545704066753,
-0.0787382572889328,
-0.006562757305800915,
0.031690362840890884,
-0.027732672169804573,
-0.0461258739233017,
0.0002242238842882216,
-0.03332499414682388,
-0.03222464770078659,
0.010709825903177261,
-0.027623306959867477,
0.006588433403521776,
0.04328792542219162,
-0.03609601780772209,
0.011123924516141415,
0.027002492919564247,
-0.006527163088321686,
-0.005041845608502626,
0.030026258900761604,
0.00003546354128047824,
-0.012321111746132374,
0.03324371576309204,
0.006968135945498943,
-0.004045157693326473,
0.01718335598707199,
-0.008240928873419762,
-0.03811081498861313,
-0.0028437140863388777,
0.01423820573836565,
-0.022915124893188477,
-0.030004221946001053,
-0.002673103241249919,
-0.002014539670199156,
-0.002565829548984766,
-0.004186707548797131,
-0.009029309265315533,
-0.03500017151236534,
-0.06894467771053314,
0.0477486215531826,
0.007076825015246868,
-0.00655179051682353,
-0.010830070823431015,
0.027401549741625786,
-0.022413840517401695,
-0.010010295547544956,
0.004318613559007645,
0.000179965965799056,
0.007605996448546648,
-0.009085027500987053,
-0.008448840118944645,
-0.014401735737919807,
0.00011850136070279405,
0.031075458973646164,
-0.0015056162374094129,
0.018779916688799858,
-0.0484062023460865,
0.0030696489848196507,
-0.00797389354556799,
-0.0035967128351330757,
-0.004296599887311459,
-0.00039044389268383384,
0.019230740144848824,
-0.015307584777474403,
0.010206582024693489,
0.07032997906208038,
-0.013231414370238781,
-0.006354592740535736,
-0.04038716480135918,
0.008595742285251617,
-0.003774606855586171,
0.040160831063985825,
0.0018092520767822862,
-0.015939390286803246,
-0.020279064774513245,
-0.004979379940778017,
-0.021419502794742584,
-0.03242333233356476,
0.009415467269718647,
-0.02136470377445221,
-0.009881674312055111,
-0.014102556742727757,
0.007883857935667038,
0.01899525709450245,
-0.01891232281923294,
-0.061446331441402435,
-0.010435226373374462,
0.0029766710940748453,
-0.010736186057329178,
0.034498270601034164,
-0.01578364335000515,
-0.02454342320561409,
-0.0029270444065332413,
-0.01235512550920248,
0.02571159228682518,
-0.005695071537047625,
-0.0021406773012131453,
-0.005365176126360893,
0.017577840015292168,
0.03532774746417999,
-0.007567763328552246,
-0.007499360479414463,
0.013694790191948414,
0.0055499752052128315,
-0.021498560905456543,
-0.019824329763650894,
0.02643597312271595,
0.01936798356473446,
0.0034572980366647243,
-0.0265487190335989,
0.009803437627851963,
0.025730276480317116,
0.016643347218632698,
-0.02790708839893341,
0.00210807123221457,
-0.010884012095630169,
0.0018011081265285611,
-0.02960563451051712,
-0.021505707874894142,
0.004997559357434511,
0.007263780105859041,
-0.03609229251742363,
0.026603028178215027,
-0.02360733225941658,
-0.023649025708436966,
0.03427780792117119,
-0.02448553778231144,
0.024975093081593513,
-0.049088891595602036,
-0.005639317445456982,
0.015378357842564583,
-0.020032480359077454,
-0.013194682076573372,
-0.01188676431775093,
0.010592994280159473,
-0.022748533636331558,
0.005228848662227392,
0.0024356443900614977,
0.030721887946128845,
0.013858250342309475,
-0.024034757167100906,
-0.012897628359496593,
0.0048275054432451725,
0.04480650648474693,
-0.014313723891973495,
-0.010660329833626747,
-0.0177601408213377,
0.025877343490719795,
0.02565155178308487,
-0.008146657608449459,
0.023015234619379044,
0.04328588396310806,
0.05189717933535576,
0.001198507146909833,
0.004643317777663469,
0.043364133685827255,
0.002825969597324729,
0.00030101052834652364,
0.016648979857563972,
0.012070716358721256,
0.03814707696437836,
-0.0010240242118015885,
0.007848639972507954,
-0.0036513146478682756,
0.00288573931902647,
-0.03378524258732796,
0.014462081715464592,
-0.007248623296618462,
-0.0029518085066229105,
0.0052921888418495655,
0.00048324617091566324,
0.01914188079535961,
0.01205611601471901,
-0.012846264988183975,
0.002526343334466219,
-0.015379071235656738,
-0.01600560173392296,
-0.015800995752215385,
-0.0005899269599467516,
-0.006369804963469505,
0.0013571474701166153,
-0.004852370359003544,
-0.0071410792879760265,
0.007269729394465685,
-0.02411246858537197,
-0.02965400740504265,
0.006677368655800819,
0.053429391235113144,
0.005629461724311113,
-0.02719530649483204,
-0.02449415996670723,
-0.025005564093589783,
0.02790478616952896,
-0.02554633468389511,
0.00030318976496346295,
0.0007804856868460774,
0.017620664089918137,
-0.007381487172096968,
-0.015791691839694977,
-0.003333840286359191,
0.02925931103527546,
0.015535786747932434,
0.026141636073589325,
-0.01912344992160797,
0.035312898457050323,
0.0007041761418804526,
0.004445731174200773,
-0.005409770179539919,
-0.028787022456526756,
0.010490349493920803,
-0.00047815090510994196,
0.009217767044901848,
0.01574818044900894,
0.026236580684781075,
0.0037970247212797403,
0.002134581096470356,
-0.014499124139547348,
-0.003176718717440963,
-0.003207823261618614,
-0.017667198553681374,
0.008080576546490192,
-0.01881094090640545,
0.04686654359102249,
0.01461112592369318,
0.00202695420011878,
0.021133538335561752,
0.05226285755634308,
0.02636384218931198,
-0.013770567253232002,
-0.02069130912423134,
-0.019163034856319427,
-0.00580043438822031,
0.033490270376205444,
0.02731492929160595,
0.007306123152375221,
0.006663501262664795,
0.01071420032531023,
-0.028206828981637955,
0.02322503924369812,
-0.004778365604579449,
-0.02313983626663685,
-0.014886821620166302,
-0.0016824175836518407,
-0.0047625587321817875,
-0.0007434172439388931,
0.02560221403837204,
-0.04202202335000038,
0.0012861225986853242,
-0.01480866875499487,
-0.02300361730158329,
0.022786587476730347,
0.005272192414849997,
-0.0017407385166734457,
0.013476020656526089,
0.003665583673864603,
-0.018252413719892502,
0.0015823362627997994,
-0.03355851769447327,
0.02251729927957058,
-0.0388774499297142,
-0.025092605501413345,
-0.020255999639630318,
0.03319575637578964,
0.019705094397068024,
0.024957090616226196,
0.013884039595723152,
-0.02758348174393177
] | [
0.12345356494188309,
0.273589551448822,
0.08804378658533096,
0.2797195613384247,
0.523466169834137,
-0.26675280928611755,
0.481817364692688,
0.04837645962834358,
-0.15554924309253693,
0.3834318518638611,
0.040221747010946274,
0.11006685346364975,
-0.037251777946949005,
0.24699591100215912,
0.05899549648165703,
0.5873055458068848,
0.1852465718984604,
0.4904070198535919,
-0.21566976606845856,
-0.7574441432952881,
-0.1519184112548828,
-0.7714221477508545,
0.16681113839149475,
-0.08893702179193497,
0.2105906754732132,
0.18130138516426086,
0.4902594983577728,
-0.1280234009027481,
-0.9385554194450378,
-0.14126162230968475,
0.09281152486801147,
0.11222401261329651,
0.15447771549224854,
-0.14558938145637512,
0.06915263831615448,
0.14070430397987366,
-0.48868516087532043,
-0.32627391815185547,
-0.2396063655614853,
-0.1320079267024994,
0.08838648349046707,
0.6497407555580139,
0.10486800223588943,
0.39851894974708557,
0.054598476737737656,
0.6231580376625061,
-1.4218568801879883,
-0.252149373292923,
-0.17148561775684357,
0.18699787557125092,
-0.3423563539981842,
-0.25162479281425476,
1.074968934059143,
-0.09274580329656601,
0.6380689740180969,
0.6740018129348755,
-0.7986862063407898,
-0.26007673144340515,
-0.07864559441804886,
-0.41652724146842957,
0.029098201543092728,
0.39991968870162964,
0.26924940943717957,
0.359681099653244,
0.3177354335784912,
0.5643320083618164,
-0.25150731205940247,
0.32154589891433716,
0.17281438410282135,
-0.2581402659416199,
0.10854928940534592,
-0.0670887678861618,
-0.6705039739608765,
0.25733768939971924,
-0.34557417035102844,
-0.132050022482872,
0.5398504137992859,
-0.138117253780365,
0.30586832761764526,
0.5774215459823608,
0.3568522334098816,
0.4646635353565216,
1.0570905208587646,
-0.2915768325328827,
0.43646711111068726,
0.08580752462148666,
-0.8868005275726318,
0.37596482038497925,
0.1136220172047615,
-0.45717084407806396,
-0.4602392613887787,
-0.2559159994125366,
-0.4098324179649353,
0.06795971840620041,
0.5474076271057129,
-0.5350407958030701,
0.2274010181427002,
-0.15562576055526733,
-0.010857917368412018,
0.19107595086097717,
-0.22157897055149078,
0.1096697598695755,
-0.17627093195915222,
-0.12665128707885742,
-0.4865066111087799,
0.21395093202590942,
-0.18853263556957245,
-0.0026738333981484175,
0.2717408835887909,
0.554954469203949,
0.2666192948818207,
0.6883161664009094,
-0.28777384757995605,
-0.22620511054992676,
-0.27971240878105164,
0.457591712474823,
0.3158392012119293,
0.12185538560152054,
-0.09362557530403137,
0.6126249432563782,
0.4827655255794525,
0.21874037384986877,
-0.02297583594918251,
0.15665081143379211,
0.3852587938308716,
0.3265796899795532,
0.012989283539354801,
0.38741880655288696,
-0.6088359355926514,
0.35735005140304565,
0.23716504871845245,
0.578375518321991,
-0.15425889194011688,
-0.5280348658561707,
-0.1929091364145279,
0.1855921596288681,
-0.10337580740451813,
0.2894449234008789,
0.5339667201042175,
0.1975708156824112,
-0.27727770805358887,
0.13742199540138245,
-0.9362964034080505,
-0.4175923764705658,
0.043785493820905685,
-0.167537659406662,
0.10827181488275528,
0.18899358808994293,
-0.592900276184082,
0.2089066207408905,
0.22587084770202637,
0.12799294292926788,
-0.2375601828098297,
-0.6510795950889587,
-0.232093945145607,
0.23987041413784027,
0.12998121976852417,
0.22017504274845123,
-0.2745666205883026,
-0.2733815610408783,
0.1385241150856018,
-0.04239501804113388,
-0.06313098967075348,
-0.18872790038585663,
-0.045051153749227524,
0.06846598535776138,
0.11149869114160538,
0.4633212685585022,
0.07684360444545746,
-0.3891535699367523,
-0.5214390158653259,
-0.14953242242336273,
-0.17513471841812134,
-0.5258177518844604,
-0.15219445526599884,
0.694141685962677,
0.3759530782699585,
1.1501917839050293,
0.12850640714168549,
0.21184642612934113,
-0.6914190053939819,
0.09663806110620499,
-0.46984973549842834,
-0.8112636804580688,
-0.16747210919857025,
-0.11349460482597351,
0.262412428855896,
0.23750075697898865,
0.9105964303016663,
0.5782896280288696,
-0.8886289000511169,
0.10603068768978119,
1.103150725364685,
-0.476120263338089,
1.0510644912719727,
-0.04360896348953247,
-0.581240177154541,
0.8764705061912537,
-0.5305740833282471,
0.2734610438346863,
0.6875582933425903,
0.7357147336006165,
0.07228349149227142,
-0.351764976978302,
-0.8912381529808044,
-0.18041378259658813,
-0.0608377568423748,
-0.23561832308769226,
-0.11085768789052963,
-0.01922888681292534,
-0.11442152410745621,
0.05577518045902252,
0.2551901638507843,
0.3069561719894409,
-0.08726321160793304,
0.27553248405456543,
0.025761380791664124,
0.3898065388202667,
0.12665250897407532,
-0.026682741940021515,
0.47791337966918945,
-0.15043607354164124,
0.16333246231079102,
0.5756573677062988,
-0.6358802914619446,
0.4889369606971741,
-0.0830087959766388,
0.26240792870521545,
0.7575690746307373,
-0.8024173378944397,
-0.09210962802171707,
0.15851633250713348,
0.03358713537454605,
-0.6393938660621643,
0.7453834414482117,
0.6000310778617859,
-0.27176928520202637,
-0.34958672523498535,
0.3330721855163574,
0.182427778840065,
0.25032028555870056,
-0.43999844789505005,
-0.2494061291217804,
0.47861823439598083,
0.037581656128168106,
-0.30976003408432007,
-0.37056490778923035,
0.30854132771492004,
-0.046065714210271835,
-0.5571268200874329,
0.13842609524726868,
0.5042501091957092,
0.014934783801436424,
0.25117966532707214,
0.12672263383865356,
0.2872109115123749,
-0.9738680720329285,
-0.260006308555603,
0.1939265877008438,
-0.0883650854229927,
-0.2658497989177704,
-0.043551042675971985,
-0.4529707431793213,
0.10960846394300461,
-0.3485192656517029,
-0.41091567277908325,
0.26776906847953796,
-0.6653538346290588,
0.012350388802587986,
0.7032466530799866,
-0.5940366387367249,
0.1983877569437027,
-0.7572779655456543,
0.166803777217865,
-0.035703618079423904,
-0.04346379637718201,
0.07823996245861053,
0.10955651104450226,
-0.10812271386384964,
-0.4310357868671417,
0.3070771396160126,
0.2570912837982178,
0.4928302466869354,
-0.47739002108573914,
-0.1634126901626587,
-0.4523853063583374,
0.14901699125766754,
-0.5954427123069763,
-0.8305251002311707,
0.30098292231559753,
-0.48761963844299316,
0.3286289870738983,
-0.36308592557907104,
-0.23839250206947327,
0.5496246218681335,
0.6932342052459717,
-0.6722148656845093,
0.4802916646003723,
0.47431206703186035,
0.28228530287742615,
0.2398722916841507,
-0.015202630311250687,
-0.3006102740764618,
0.611758828163147,
0.5210690498352051,
-0.14880876243114471,
-0.5286750793457031,
-0.4330177307128906,
-5.733007907867432,
0.264749675989151,
-0.5453757047653198,
0.09327605366706848,
-0.49757102131843567,
0.3517429828643799,
0.7360389828681946,
0.20098358392715454,
-0.2050330936908722,
-0.3333722651004791,
0.4911271929740906,
0.7217504382133484,
0.2973388433456421,
0.20155049860477448,
-0.13813261687755585,
0.765449583530426,
0.40402674674987793,
-0.44048967957496643,
-0.6570037603378296,
0.20039543509483337,
0.0658615455031395,
0.08848737180233002,
0.06582676619291306,
-0.40368321537971497,
0.3552827835083008,
0.626276433467865,
-0.1617276668548584,
0.008191721513867378,
-0.1393241435289383,
0.041984673589468,
-0.41617950797080994,
-0.8861307501792908,
-0.1480722278356552,
-0.639169454574585,
-0.02848018892109394,
0.19614489376544952,
0.1353883147239685,
-0.21364286541938782,
0.14578849077224731,
-0.18215571343898773,
0.03424397110939026,
-0.4652107357978821,
0.08613989502191544,
0.03005519136786461,
0.6295570731163025,
-0.5248517990112305,
-0.3917877674102783,
-0.09240859746932983,
-0.270029217004776,
0.7600217461585999,
-0.22355976700782776,
-0.47579771280288696,
0.5996125936508179,
0.4799409508705139,
0.11366982012987137,
0.16211453080177307,
-0.20315298438072205,
-0.37784162163734436,
-0.4227655529975891,
0.12518826127052307,
0.23748981952667236,
-0.12273416668176651,
0.038656629621982574,
-0.1912369579076767,
-0.49261873960494995,
-0.03787682577967644,
-0.42982617020606995,
-0.9494274258613586,
-0.04919309541583061,
0.5460071563720703,
-0.6908801794052124,
0.20459799468517303,
0.1958073228597641,
-0.7230170965194702,
-0.05362844839692116,
-0.07792762666940689,
-0.4826571047306061,
0.12878762185573578,
-0.20385609567165375,
0.15672242641448975,
-0.0625012144446373,
0.0763862133026123,
0.03686854615807533,
0.04182020202279091,
-0.01636900007724762,
-0.7204042673110962,
-0.5713415741920471,
-0.07761570811271667,
-0.6408478021621704,
0.3869803547859192,
0.6641863584518433,
-0.008869769982993603,
-0.28232601284980774,
0.29617998003959656,
0.05181171000003815,
0.039737626910209656,
1.1782394647598267,
-0.047608815133571625,
0.5326645970344543,
-0.1334351748228073,
0.35409191250801086,
-0.23599031567573547,
0.2779522240161896,
-0.7350520491600037,
-0.329262912273407,
-0.1431112289428711,
-0.7279633283615112,
-0.046055134385824203,
0.6934306025505066,
-0.6795628666877747,
-0.09858692437410355,
-0.41131591796875,
0.24647240340709686,
0.015658607706427574,
0.20936621725559235,
-0.5106866955757141,
0.22228118777275085,
0.10443247854709625,
0.201263427734375,
-0.9173355102539062,
0.06594941020011902,
0.4337695837020874,
0.3233885169029236,
-0.9172723889350891,
0.2970447242259979,
-0.07080276310443878,
0.7486580014228821,
0.13445061445236206,
-0.293569415807724,
0.29749608039855957,
-0.7787134051322937,
0.046824365854263306,
-0.03452493995428085,
-0.07605880498886108,
-0.11141794174909592,
-0.2102140337228775,
-0.5224791765213013,
-0.716140866279602,
0.0045624421909451485,
0.6134709715843201,
0.019694563001394272,
-0.5535086989402771,
0.23580873012542725,
-0.20207086205482483,
0.21300837397575378,
-0.06465207785367966,
0.49800416827201843,
-0.17777875065803528,
0.11166655272245407,
0.44453030824661255,
-0.007968598045408726,
0.4938009977340698,
1.172446846961975,
0.35683178901672363,
-0.16266004741191864,
-0.06295210123062134,
0.4675029218196869,
0.6283295154571533,
-0.15555614233016968,
0.16473793983459473,
0.045765165239572525,
-0.26198384165763855,
-0.7616002559661865,
0.22353076934814453,
0.553657054901123,
-0.0446288026869297,
-0.11038002371788025,
-0.4844938814640045,
-0.5440787076950073,
0.20664535462856293,
0.31023311614990234,
-0.09707094728946686,
-0.2882811725139618,
0.33013004064559937,
0.2426210194826126,
0.07658839225769043,
-0.35377123951911926,
-0.32550445199012756,
0.008015952073037624,
-0.17088636755943298,
-0.2781604826450348,
-1.1972663402557373,
-0.022835174575448036,
0.1588200330734253,
0.6595091223716736,
-0.5749169588088989,
-0.34321272373199463,
-0.5487973690032959,
-0.4441675543785095,
0.2359214723110199,
-0.09719978272914886,
-0.013226736336946487,
0.4495754539966583,
-0.13323989510536194,
0.01470913365483284,
-0.5381245613098145,
0.38759368658065796,
0.278217613697052,
-0.22750993072986603,
-0.1328079253435135,
-0.4844457805156708,
0.5575578808784485,
-0.5818207859992981,
0.15520653128623962,
0.3499021530151367,
-0.8331501483917236,
-0.10970388352870941,
-0.43222540616989136,
-0.2377358376979828,
0.7668054103851318,
-0.029683588072657585,
-0.24863862991333008,
0.3382919132709503,
0.315154105424881,
-0.3154575526714325,
0.20032957196235657,
0.15760141611099243,
-0.2030276358127594,
-0.9614934325218201,
0.10987788438796997,
0.39056628942489624,
-0.17034561932086945,
-0.24414780735969543,
-0.224546417593956,
-0.15554092824459076,
0.5896687507629395,
0.5757432579994202,
-0.1062282994389534,
0.1339282989501953,
0.06497921794652939,
-0.7567805647850037,
0.13737444579601288,
0.23754306137561798,
-0.2699810862541199,
-0.5900321006774902,
-0.1117626428604126,
-0.07249439507722855,
0.20376059412956238,
0.0018417135579511523,
0.32219526171684265,
0.5296687483787537,
0.2926275432109833,
-0.1291496455669403,
-0.18215544521808624,
0.0909261554479599,
-0.05649067834019661,
-0.7647821307182312,
-0.3891661763191223,
-0.5780906677246094,
0.16939465701580048,
-0.33838072419166565,
0.34633582830429077,
0.20422010123729706,
-0.8610982894897461,
0.8845177888870239,
-0.06933782249689102,
-0.053476639091968536,
-0.004293064586818218,
0.027606751769781113,
-0.16122093796730042,
0.06142957881093025,
0.44279980659484863,
-0.4781203866004944,
0.04841132089495659,
0.07160643488168716,
0.18696348369121552,
-0.03352266922593117,
-0.64419025182724,
0.2641468048095703,
-0.47527533769607544,
-0.06947128474712372,
0.248817577958107,
0.2070079743862152,
0.6700161099433899,
-0.21007302403450012,
0.5851181149482727,
-0.3340733051300049,
0.041905779391527176,
-0.008758016861975193,
-0.5745163559913635,
-0.30841121077537537,
0.51661616563797,
-0.42555713653564453,
-0.45209720730781555,
-0.0559111088514328,
0.033023592084646225,
0.09749386459589005,
0.055399339646101,
-0.06875814497470856,
-0.34639379382133484,
-0.1994730681180954,
0.4394514262676239,
0.0638212338089943,
-0.22062915563583374,
0.6143002510070801,
0.32367414236068726,
-0.4034685492515564,
-0.3779061436653137,
0.255174458026886,
-0.020926818251609802,
-0.5191974639892578,
0.24780599772930145,
0.8877949714660645,
-0.5856239199638367,
0.45966604351997375,
0.14780083298683167,
0.40999311208724976,
0.028454653918743134,
-0.5630435943603516,
0.32547345757484436,
0.2940869629383087,
-0.4648962616920471,
-0.3032778203487396,
0.5890594720840454,
-0.37862369418144226,
-0.019808610901236534,
0.10332373529672623,
-0.7817329168319702,
-0.0019680222030729055,
0.14093908667564392,
-0.06631510704755783,
0.8086372017860413,
1.0418897867202759,
-0.35152289271354675,
-0.09884712100028992,
0.17849135398864746,
-0.6953887939453125,
0.5424773097038269,
-0.2489195168018341,
-0.24293740093708038,
0.7673527598381042,
0.19810648262500763,
-0.0644468292593956,
0.16363625228405,
0.243586003780365,
0.3349344730377197,
0.14155806601047516,
-0.25292152166366577,
-0.23728857934474945,
0.12384199351072311,
-0.09884390980005264,
0.019040904939174652,
0.0159667506814003,
-0.3610993027687073,
-0.07623552531003952,
0.30245307087898254,
-0.02653287723660469,
0.32410311698913574,
0.2628420293331146,
0.058635614812374115,
0.32809069752693176,
0.6002658009529114,
-0.1054755225777626,
-0.5213332176208496,
0.004369855392724276,
0.2009531706571579,
0.20265315473079681,
0.013599298894405365,
-0.3748812675476074,
0.03601367771625519,
-0.21622954308986664,
0.5872307419776917,
-0.29492083191871643,
0.45440757274627686,
-0.01613418199121952,
0.3416101336479187,
0.6510004997253418,
0.2610137462615967,
-0.3135037124156952,
-0.353056401014328,
0.24382677674293518,
-0.3940352499485016,
-0.5524306893348694,
-0.2023242861032486,
0.0076896692626178265,
-0.31239548325538635,
0.6844128370285034,
0.18541373312473297,
0.18376652896404266,
0.3894346356391907,
-0.0834047794342041,
-0.7427012920379639,
-0.3005429804325104,
0.03439716994762421,
0.9587743282318115,
-0.6214984655380249,
0.13845834136009216,
-0.1779603660106659,
0.12110661715269089,
-0.48057880997657776,
0.06142015755176544,
-0.29865172505378723,
-0.35655367374420166,
-0.049453575164079666,
-0.46669378876686096,
-0.1329347789287567,
0.039782773703336716,
0.9143824577331543,
-0.13654622435569763,
-0.0680084303021431,
0.06238275766372681,
-0.32397860288619995,
-0.16761364042758942,
0.7342464327812195,
-0.11599288880825043,
0.9797446727752686,
-0.8930054306983948,
0.017620110884308815,
-0.4944390058517456,
0.1598922461271286,
-0.41261011362075806,
0.6388553380966187,
-0.32398685812950134,
-0.011783896014094353,
-0.05080582946538925,
-0.13025307655334473,
0.09490516036748886,
0.10409675538539886,
0.17343321442604065,
-0.29428428411483765,
0.07287582010030746,
0.47912395000457764,
-0.017706403508782387,
0.4915159344673157,
-0.32501330971717834,
0.08403834700584412,
0.24662290513515472,
-0.018894344568252563,
-0.3412315249443054,
0.1526179164648056,
0.24771106243133545,
-0.5977280735969543,
-0.11958461254835129,
0.683622419834137,
-0.4006900191307068,
-0.016121618449687958,
0.5682636499404907,
0.6289718151092529,
-0.3678567707538605,
-0.03241782635450363,
-0.4987579882144928,
0.23876629769802094,
0.45121511816978455,
0.02987511083483696,
-0.3485970199108124,
-0.014335117302834988,
-0.3380953371524811,
-0.07351039350032806,
-0.40550002455711365,
-0.22569403052330017,
-0.1561216562986374,
-0.37194088101387024,
-0.3027309477329254,
-0.6073776483535767,
-0.12656031548976898,
0.3960091471672058,
-0.17237746715545654,
-0.28638628125190735,
-0.3997889459133148,
-0.035714417695999146
] |
We studied the influence of patient, leukaemia and treatment characteristics on the kinetics of Minimal Residual Disease (MRD) clearance in children with lymphoblastic leukaemia treated using an intensive risk stratified approach. UK MRC protocol ALL97 (1997–1999), and its amended version ALL 97/99 (1999–2002), compared the efficacy and toxicity of dexamethasone (DEX) with prednisolone (PRED), and 6-thioguanine (TG) with 6-Mercaptopurine (MP) in a randomised fashion. The trial produced a 5 year event-free survival (EFS) of 80%, with better systemic and Central Nervous System outcomes in DEX compared with PRED recipients but no difference between TG and MP recipients. Several changes to the risk stratification and treatment regimens during the period of the trial provided an opportunity to determine their impact on MRD clearance. We compared this with clearance in those treated on the successor trial ALL 2003 (more intensive induction containing DEX and Pegylated Asparaginase). The variables investigated for their potential influence on MRD status at the end of induction (EOI) were: NCI Risk; Asparaginase intensity (Erwinia Asparaginase [ERW] in ALL 97 and early part of ALL97/99 vs native or Pegylated E. Coli Asparaginase [E. Coli] in later part of ALL 97/99 and ALL2003); DEX vs PRED; and marrow response at day 8/15 of induction (Slow Early Response [SER] >25% blasts vs Rapid Early Response [RER] ⩽ 25% blasts). MRD was assessed using either a semi-quantitative sequence-specific PCR (ALL97) or Real-Time Quantitative PCR (ALL99 and ALL 2003) of antigen receptor gene re-arrangements at EOI. MRD status was defined as NEG if no MRD was detected by two markers sensitive to 10 −4 ; POS if > 10 −4 , and Positive Outside Quantitative Range (POQR) if positive −4 . Results were available from retrospective testing in 66 ALL97 and 76 ALL97/99 patients, and 204 ALL2003 patients monitored prospectively. There was no significant difference in the proportions of patients MRD NEG, POS or POQR in steroid or NCI sub-groups. Significantly more ERW Asparaginase recipients were MRD POS compared with E.Coli (p −4 at EOI have the same low risk of relapse as those who have undetectable MRD. | [
0.00975025724619627,
0.00015774276107549667,
-0.02063675969839096,
-0.008999026380479336,
-0.006359366700053215,
0.018281109631061554,
0.010437414050102234,
0.010751434601843357,
-0.01180607546120882,
-0.04921110346913338,
-0.000284865265712142,
0.01415397971868515,
-0.013887157663702965,
0.016652287915349007,
-0.01694522611796856,
0.022253312170505524,
-0.035523422062397,
0.01316969096660614,
0.013803797774016857,
0.03002006933093071,
-0.002883537206798792,
0.01488037034869194,
0.009890472516417503,
0.02761068195104599,
-0.033337537199258804,
0.015938613563776016,
-0.03024355322122574,
0.0067192139104008675,
0.010121474042534828,
0.003172521945089102,
0.002508113393560052,
-0.0015727013815194368,
-0.00010973727330565453,
-0.0089832479134202,
-0.0012407463509589434,
0.009400964714586735,
-0.0012749910820275545,
0.015260366722941399,
0.01124793104827404,
-0.0058016348630189896,
-0.002866088878363371,
-0.012316783890128136,
0.005390423350036144,
-0.014392794109880924,
-0.010646188631653786,
-0.017831221222877502,
-0.0017503708368167281,
0.003175661899149418,
0.01113416813313961,
0.008305384777486324,
-0.013558020815253258,
-0.03089539334177971,
-0.015215975232422352,
-0.005146448500454426,
-0.006002066656947136,
0.002291633514687419,
0.018232036381959915,
0.01733802631497383,
-0.0001331681851297617,
0.022022757679224014,
0.010200900956988335,
-0.00382820563390851,
0.007067151367664337,
-0.019105367362499237,
-0.005315500311553478,
-0.06693175435066223,
0.015536641702055931,
0.022059137001633644,
-0.020878879353404045,
-0.006412594113498926,
-0.011413880623877048,
0.013782210648059845,
-0.011366776190698147,
-0.02151358127593994,
-0.017791494727134705,
0.010261405259370804,
-0.006971494294703007,
0.030569758266210556,
0.005050963722169399,
-0.033172357827425,
0.00012614671140909195,
0.0011397779453545809,
-0.020309722051024437,
0.018431469798088074,
0.005670120939612389,
-0.01765403524041176,
-0.02602887898683548,
-0.008486343547701836,
0.0021164175122976303,
-0.014480051584541798,
0.012100964784622192,
-0.015343365259468555,
-0.009393819607794285,
-0.008569872006773949,
-0.041368573904037476,
0.004085130989551544,
0.004559702705591917,
-0.004041381645947695,
0.00732775591313839,
-0.01926378719508648,
-0.01540388073772192,
-0.016485098749399185,
0.016706567257642746,
0.023614950478076935,
0.0011104083387181163,
0.005175916478037834,
-0.010453767143189907,
0.023375308141112328,
-0.021557141095399857,
0.009968951344490051,
-0.01784306764602661,
0.017504211515188217,
-0.0043836431577801704,
-0.005697221029549837,
0.022594116628170013,
0.0002886061556637287,
-0.013011418282985687,
0.022470680996775627,
0.014749870635569096,
0.019867833703756332,
0.016923384740948677,
0.0008853496983647346,
0.004838647786527872,
-0.033451758325099945,
0.0026003671810030937,
0.002092614769935608,
-0.01942300796508789,
0.022134356200695038,
0.008249669335782528,
0.009001025930047035,
-0.00839894637465477,
-0.013314520008862019,
-0.0023880042135715485,
0.00677102617919445,
0.0014852252788841724,
0.0003865755279548466,
0.005488220136612654,
-0.002469200175255537,
-0.004051764030009508,
0.017335329204797745,
-0.0023138197138905525,
0.011435097083449364,
0.0024079696740955114,
0.016216058284044266,
0.0035120733082294464,
0.00575809134170413,
0.004304387606680393,
-0.0007402595365419984,
0.002440128941088915,
-0.0025589708238840103,
-0.005703647620975971,
0.014192022383213043,
-0.004636309575289488,
-0.015430556610226631,
0.031147964298725128,
0.0008722138591110706,
-0.028786079958081245,
0.0023153680376708508,
0.00421477435156703,
0.03697767108678818,
-0.023885708302259445,
0.0272532906383276,
-0.00278919143602252,
0.010425914078950882,
0.023544806987047195,
-0.0023922156542539597,
0.009364370256662369,
-0.011627096682786942,
-0.013159925118088722,
0.004786656238138676,
-0.0006541834445670247,
-0.009539950639009476,
-0.007668287493288517,
0.005536187440156937,
-0.02172883227467537,
-0.009342310950160027,
-0.012404557317495346,
0.007404159288853407,
-0.007600362412631512,
0.0662662610411644,
-0.02546597272157669,
0.013757179491221905,
-0.004866717848926783,
-0.0030617425218224525,
-0.0016118010971695185,
-0.0005314268637448549,
0.007681696210056543,
-0.004265833646059036,
-0.004814332351088524,
0.018240030854940414,
0.024228516966104507,
0.015815703198313713,
-0.002938954159617424,
-0.010751177556812763,
-0.05724227428436279,
0.001927092089317739,
-0.009067956358194351,
0.0044654859229922295,
-0.008901888504624367,
-0.008861887268722057,
0.03476687893271446,
-0.0120264096185565,
0.019790243357419968,
-0.02421388030052185,
0.011123139411211014,
0.009295585565268993,
-0.01179016474634409,
-0.02631116658449173,
0.004342040978372097,
-0.014918601140379906,
0.029081188142299652,
-0.009893222711980343,
-0.002048713155090809,
-0.005671256221830845,
0.02984190545976162,
-0.026539653539657593,
0.00544890109449625,
-0.007385597564280033,
0.015911012887954712,
-0.01545826904475689,
-0.004551004618406296,
0.02933546155691147,
-0.01873118057847023,
-0.0026598884724080563,
0.010958111844956875,
0.020514391362667084,
0.005780196748673916,
0.01149805635213852,
0.008261587470769882,
0.011506523005664349,
-0.006842066068202257,
-0.004220646806061268,
-0.014030355960130692,
0.04254988580942154,
-0.00311934482306242,
-0.012547267600893974,
0.012883994728326797,
-0.007625372149050236,
0.015788400545716286,
-0.02450007013976574,
-0.015739653259515762,
0.011063521727919579,
-0.016022667288780212,
0.022735578939318657,
0.04562138766050339,
0.0033535934053361416,
0.02510305494070053,
0.010866032913327217,
0.001035188906826079,
-0.003941657487303019,
0.009492981247603893,
-0.014111841097474098,
0.014284318313002586,
0.009091551415622234,
0.0053815715946257114,
-0.01352662779390812,
0.0031061661429703236,
-0.0012768367305397987,
0.024874145165085793,
-0.028884628787636757,
-0.0075242486782372,
0.005333972629159689,
-0.029028918594121933,
-0.008765289559960365,
0.009432334452867508,
-0.000612128060311079,
0.022948607802391052,
0.026400785893201828,
0.004302455112338066,
-0.009156649932265282,
0.011433560401201248,
-0.010146237909793854,
-0.008279344066977501,
-0.08184707164764404,
-0.011646376922726631,
0.0077663930132985115,
0.006967407185584307,
0.0030761435627937317,
-0.022297661751508713,
-0.001659533241763711,
-0.010333461686968803,
-0.003926660865545273,
-0.015647519379854202,
0.004232828970998526,
0.0007643608842045069,
-0.00477595254778862,
0.0009543482447043061,
-0.012523140758275986,
-0.008126755245029926,
0.007512624841183424,
-0.03090631775557995,
-0.010874887928366661,
-0.034716613590717316,
0.000738760456442833,
0.019519537687301636,
0.010496203787624836,
0.025362730026245117,
-0.01703033782541752,
0.021637119352817535,
0.010982837527990341,
-0.004088512156158686,
-0.031685590744018555,
0.008043382316827774,
-0.011421585455536842,
-0.025534873828291893,
0.004468868020921946,
0.0027165000792592764,
0.004306434653699398,
-0.0063429949805140495,
0.02076771855354309,
-0.00004967115819454193,
0.0004962082020938396,
0.023562254384160042,
-0.008671839721500874,
0.0011553263757377863,
0.00667475163936615,
-0.018411461263895035,
0.009713428094983101,
0.02622760459780693,
-0.005166022107005119,
0.026805076748132706,
0.017862707376480103,
-0.021026140078902245,
-0.03641482815146446,
0.011027101427316666,
-0.01716969907283783,
0.012718090787529945,
-0.015750987455248833,
-0.0028652548789978027,
-0.013128148391842842,
-0.009264322929084301,
-0.009762346744537354,
-0.017236020416021347,
-0.0025776568800210953,
-0.042901597917079926,
0.037321027368307114,
0.0013805916532874107,
-0.014175763353705406,
0.012200254946947098,
0.009226378053426743,
-0.027372274547815323,
-0.011861579492688179,
0.007756590377539396,
-0.02425016090273857,
-0.025653183460235596,
-0.028532009571790695,
0.0003151789424009621,
-0.02218419685959816,
-0.009531138464808464,
-0.01369352638721466,
0.005843509919941425,
0.01291228923946619,
-0.008086963556706905,
-0.004663410596549511,
0.007339212577790022,
-0.031184235587716103,
0.0022838921286165714,
-0.025448814034461975,
-0.01555112935602665,
0.005304798483848572,
-0.0014972209464758635,
0.010829627513885498,
-0.012095521204173565,
-0.006592411082237959,
-0.00850294902920723,
-0.008177187293767929,
0.01667432114481926,
0.002502922434359789,
-0.0359334796667099,
-0.01561178918927908,
-0.0177112128585577,
0.023437516763806343,
0.007722773589193821,
0.003064128803089261,
-0.0017009894363582134,
0.01023697666823864,
-0.013078075833618641,
-0.015894614160060883,
0.011286618188023567,
-0.003769827540963888,
0.006211905274540186,
-0.011894481256604195,
-0.003476674435660243,
0.0012423498556017876,
-0.003929526545107365,
-0.004609705414623022,
0.01915232092142105,
0.008063189685344696,
-0.0057191988453269005,
0.02014780044555664,
0.014093015342950821,
0.07288450002670288,
0.006859921384602785,
0.0161484032869339,
-0.01592085510492325,
0.005221732892096043,
-0.018713142722845078,
-0.013785110786557198,
0.009316402487456799,
0.003580294083803892,
0.025685371831059456,
0.012244402430951595,
-0.0036722891964018345,
-0.01688694767653942,
-0.008267264813184738,
-0.003397692460566759,
-0.0015177479945123196,
-0.020172206684947014,
0.011265714652836323,
0.0037038999143987894,
0.0048190876841545105,
0.019766991958022118,
-0.02495153807103634,
-0.029538076370954514,
-0.017917245626449585,
0.002222821582108736,
-0.01274410542100668,
0.0384727381169796,
-0.008762823417782784,
-0.013008077628910542,
0.00834098644554615,
0.0018797570373862982,
0.0122076366096735,
-0.010312089696526527,
-0.02291170507669449,
0.02839202992618084,
0.01737372577190399,
0.006636724807322025,
-0.02869798056781292,
0.007365056779235601,
0.018581364303827286,
-0.012956663966178894,
-0.01620887964963913,
-0.008288934826850891,
-0.001901200506836176,
-0.022465623915195465,
0.013581533916294575,
0.01709616929292679,
-0.010722259059548378,
-0.01637258008122444,
0.006344554014503956,
-0.011494646780192852,
0.00039227213710546494,
0.016578201204538345,
0.02354380488395691,
-0.05524095892906189,
-0.031327083706855774,
-0.017372362315654755,
-0.005808700807392597,
-0.00042649824172258377,
-0.020308736711740494,
-0.013769465498626232,
-0.008358538150787354,
0.025228682905435562,
0.00946776568889618,
0.017101600766181946,
-0.022914225235581398,
0.0028615491464734077,
0.002431723056361079,
-0.02831145003437996,
-0.028535014018416405,
0.025780484080314636,
0.0060010990127921104,
0.008943367749452591,
0.0006103317718952894,
-0.02751065418124199,
0.014329999685287476,
-0.014876717701554298,
0.013060932978987694,
-0.003637258894741535,
-0.012931413017213345,
-0.02570069208741188,
0.013954395428299904,
0.006807041820138693,
0.003132095094770193,
0.008586561307311058,
0.031367961317300797,
0.0007913793670013547,
-0.0748513713479042,
0.007339799776673317,
0.01713363081216812,
-0.010159224271774292,
-0.0030507934279739857,
-0.0018440971616655588,
-0.01639964058995247,
-0.012286383658647537,
0.029699573293328285,
-0.005864142905920744,
-0.016016799956560135,
0.006508265621960163,
-0.04225994646549225,
-0.01357458159327507,
0.012821035459637642,
-0.0026181968860328197,
-0.0029138335958123207,
-0.00858551636338234,
-0.024853378534317017,
0.02830984815955162,
0.01845233142375946,
0.0011597690172493458,
-0.022767696529626846,
-0.012502042576670647,
-0.01171618141233921,
-0.08157427608966827,
-0.0001817750744521618,
-0.02522975392639637,
-0.010076025500893593,
-0.006384760141372681,
-0.01913679763674736,
0.009776829741895199,
-0.015920769423246384,
0.025545915588736534,
-0.01578149013221264,
0.009754481725394726,
-0.02494995668530464,
0.011140777729451656,
-0.018001049757003784,
0.006773412227630615,
-0.0042437356896698475,
0.030967706814408302,
-0.021018169820308685,
-0.015697056427598,
-0.01869012415409088,
-0.007654416374862194,
-0.010305393487215042,
-0.003153702011331916,
-0.0010889675468206406,
-0.007881324738264084,
-0.025020942091941833,
0.004858713131397963,
0.016284191980957985,
-0.004509135149419308,
-0.0014169559581205249,
0.022102132439613342,
-0.023670930415391922,
-0.01136881671845913,
-0.026197221130132675,
-0.00402500294148922,
-0.008351700380444527,
-0.0171215683221817,
0.0040352800861001015,
0.022270914167165756,
-0.007496332749724388,
-0.006513858214020729,
0.0026725884526968002,
0.015219444409012794,
0.013852974399924278,
-0.038572560995817184,
0.006979078520089388,
0.010074476711452007,
-0.009960617870092392,
-0.0066599659621715546,
0.009174739941954613,
-0.00034321151906624436,
-0.014437336474657059,
0.0035511325113475323,
-0.001315034693107009,
-0.007149272598326206,
0.014434577897191048,
-0.010311609134078026,
0.0020096679218113422,
-0.029368726536631584,
0.007088526152074337,
-0.0008183545432984829,
-0.004374989774078131,
0.0051456899382174015,
0.07140721380710602,
-0.02545911818742752,
-0.0000062586041167378426,
-0.02262907847762108,
0.01733684353530407,
0.007715144660323858,
0.015979144722223282,
-0.02007383666932583,
-0.0385793074965477,
-0.006892126984894276,
-0.008321746252477169,
-0.010802319273352623,
0.008209871128201485,
0.014806142076849937,
-0.023674309253692627,
0.002069304697215557,
0.019141003489494324,
0.027044065296649933,
0.006910428870469332,
0.007887391373515129,
0.016699418425559998,
0.016705911606550217,
-0.034173473715782166,
0.019360916689038277,
-0.009110369719564915,
-0.016390739008784294,
0.007489711046218872,
-0.01367582194507122,
0.01339200884103775,
-0.0008159817662090063,
0.002063026186078787,
0.00026985444128513336,
0.005051977001130581,
0.021749887615442276,
0.008052945137023926,
0.042170219123363495,
-0.002843433292582631,
0.01650923676788807,
-0.009008588269352913,
0.004596052225679159,
-0.005270244553685188,
0.007774461060762405,
-0.000936589203774929,
-0.015052875503897667,
0.0038575492799282074,
0.03962506726384163,
-0.0071395267732441425,
0.0056840176694095135,
-0.0006482468452304602,
-0.014662889763712883,
0.008471832610666752,
0.005026131868362427,
0.008077964186668396,
-0.03115714341402054,
0.009198703803122044,
0.013468521647155285,
-0.01460975594818592,
0.018778281286358833,
-0.02393357641994953,
-0.003970056772232056,
0.005324066616594791,
-0.007826867513358593,
0.010836821980774403,
-0.028915811330080032,
0.04118052124977112,
-0.020485233515501022,
0.01846790872514248,
-0.01846432313323021,
0.002419693861156702,
0.012012929655611515,
0.010817812755703926,
0.005045481026172638,
0.006876468658447266,
-0.0014147774782031775,
0.016708388924598694,
0.009960555471479893,
0.03380034118890762,
-0.026351498439908028,
0.0040390370413661,
-0.005792483687400818,
-0.005453598685562611,
0.010442518629133701,
-0.01279203686863184,
0.00014061247929930687,
-0.004028498660773039,
-0.00332514476031065,
0.03354640305042267,
-0.009966935962438583,
-0.008174345828592777,
0.010824454948306084,
0.03016063943505287,
0.0027234742883592844,
0.00572659308090806,
0.009194567799568176,
0.008367677219212055,
0.034005530178546906,
0.0071178460493683815,
0.010914958082139492,
-0.002916756784543395,
0.008945335634052753,
0.0031056636944413185,
-0.005807805806398392,
-0.005456364713609219,
0.00800374336540699,
-0.0065197874791920185,
0.009665277786552906,
-0.030141809955239296,
-0.0012290808372199535,
-0.005359715316444635,
0.028197767212986946,
-0.026076149195432663,
-0.014014245010912418,
-0.001774168573319912,
-0.0031832284294068813,
0.013326206244528294,
0.013864336535334587,
0.011203228496015072,
-0.026708364486694336,
-0.011883211322128773,
-0.018664658069610596,
-0.01989862695336342,
-0.02661311998963356,
-0.006151270586997271,
0.030414052307605743,
-0.007468343712389469,
-0.00451267696917057,
-0.010408712550997734,
0.0006059920415282249,
0.006687886081635952,
0.017824754118919373,
0.004207829479128122,
0.011815737932920456,
-0.024050939828157425,
0.004815878812223673,
-0.02090180478990078,
0.003922679461538792,
-0.009179419837892056,
-0.0055269962176680565,
0.019023656845092773,
-0.027536539360880852,
0.009262033738195896,
0.005455309990793467,
-0.002770925872027874,
-0.004914162214845419,
0.00971631333231926,
0.01570705883204937,
-0.005912615917623043,
0.003551650792360306,
0.007177512161433697,
0.003870034124702215,
-0.0032930420711636543,
0.0028157345950603485,
-0.0032270385418087244,
-0.0025443374179303646,
0.012395546771585941,
0.014115789905190468,
0.00446929968893528,
0.014657026156783104,
-0.025601087138056755,
0.009935557842254639,
0.002880589570850134,
0.0026829540729522705,
0.008671656250953674,
-0.007327835075557232,
-0.006978361867368221,
-0.008701615035533905,
-0.00919514149427414,
0.013704024255275726,
-0.020456701517105103,
0.00629777554422617,
0.02894590236246586,
0.0024857360403984785,
0.0015449714846909046,
0.0164116732776165,
-0.0030108161736279726,
-0.0033897580578923225,
-0.017981283366680145,
0.014388099312782288,
-0.011032707057893276,
0.014151112176477909,
0.01544875930994749,
-0.010415255092084408,
-0.008366445079445839,
-0.010346620343625546,
-0.007727527059614658,
0.014639319851994514,
-0.0001634389627724886,
-0.002410994376987219,
0.006333382800221443,
-0.014391280710697174,
-0.010585549287497997,
-0.0030653919093310833,
-0.015747981145977974,
-0.013667967170476913,
0.013285578228533268,
0.014608403667807579,
0.00643298402428627,
-0.0072302925400435925,
-0.004336169920861721,
-0.01855417527258396,
-0.0066698878072202206,
-0.02148468978703022
] | [
0.239756241440773,
0.1206311285495758,
-0.019359027966856956,
-0.015079077333211899,
-0.36476531624794006,
0.10791657865047455,
0.12142206728458405,
-0.566470742225647,
-0.19711214303970337,
0.19087962806224823,
0.3804433047771454,
0.6010805368423462,
-0.08148607611656189,
0.3818512260913849,
-0.16339875757694244,
0.7321524024009705,
0.9080517888069153,
0.19150440394878387,
-0.056310974061489105,
-0.6295571327209473,
-0.15170536935329437,
-0.6492331624031067,
0.6446540951728821,
-0.39128047227859497,
0.08737223595380783,
0.46471211314201355,
0.7194135189056396,
0.1069461926817894,
-0.06357745081186295,
0.20585422217845917,
-0.1625003218650818,
0.7332457900047302,
-0.007779211271554232,
-0.35243088006973267,
0.19539187848567963,
1.0203828811645508,
-0.14829586446285248,
-0.0013285366585478187,
-0.10384338349103928,
-0.450690895318985,
-0.10391592234373093,
-0.24641932547092438,
-0.027543583884835243,
0.35908523201942444,
-0.3930716812610626,
0.21767666935920715,
-0.5924715399742126,
0.5482959151268005,
-0.13572876155376434,
-0.10063481330871582,
-0.1084020733833313,
0.3210383355617523,
0.23876240849494934,
0.07955821603536606,
0.015217088162899017,
0.23322394490242004,
-0.730341374874115,
-0.20703548192977905,
-0.27916762232780457,
-0.34822607040405273,
0.07152584940195084,
0.03192737326025963,
-0.1259010285139084,
0.4771250784397125,
0.02504010684788227,
0.297546923160553,
-0.037134621292352676,
0.4552149772644043,
-0.5557947158813477,
-0.02683131955564022,
0.30526548624038696,
-0.025390636175870895,
-0.5329264998435974,
0.07500053197145462,
-0.14385521411895752,
0.34852713346481323,
-0.12218203395605087,
-0.7783415913581848,
0.3319641351699829,
0.2335982620716095,
0.5149804949760437,
-0.19364583492279053,
0.43595489859580994,
0.20612254738807678,
0.1946355551481247,
0.4688204824924469,
0.16336748003959656,
0.8313061594963074,
-0.33095231652259827,
-0.1682390719652176,
-0.37976136803627014,
0.384299635887146,
0.3915138840675354,
0.16449375450611115,
-0.0444985069334507,
0.11418619751930237,
-0.2330053150653839,
-0.19627872109413147,
0.06883983314037323,
-0.13927710056304932,
0.20080828666687012,
-0.4017098844051361,
-0.2976093888282776,
-0.013316267170011997,
-0.1478954553604126,
-0.2982895076274872,
-0.03727298602461815,
-0.7008849382400513,
-0.6737456321716309,
-0.0634983479976654,
-0.3427945673465729,
0.46059319376945496,
-0.05531183257699013,
-0.19042810797691345,
-0.03647284209728241,
0.031053418293595314,
0.22614789009094238,
0.025404395535588264,
-0.021769357845187187,
0.002327241934835911,
-0.0500885434448719,
0.6918171644210815,
-0.06005445122718811,
0.09743890166282654,
0.3804832994937897,
-0.023499004542827606,
0.4706600606441498,
0.3281441330909729,
0.14567652344703674,
0.14828792214393616,
0.19750483334064484,
0.6438524723052979,
-0.028779104351997375,
-0.129747673869133,
-0.12575143575668335,
-0.4617287218570709,
0.16372686624526978,
-0.05143842101097107,
0.09226860105991364,
-0.10963979363441467,
0.008850343525409698,
-0.29969245195388794,
-0.516496479511261,
-0.03968627005815506,
0.16249574720859528,
-0.06043129786849022,
0.2666146159172058,
0.44759851694107056,
-0.1588762253522873,
0.11111091077327728,
0.08427002280950546,
-0.008647867478430271,
-0.10962020605802536,
-0.16622377932071686,
0.17450638115406036,
0.30439630150794983,
-0.5322151780128479,
-0.040373753756284714,
-0.8077467083930969,
-0.08288730680942535,
0.2496582418680191,
-0.03611401841044426,
0.007506715599447489,
-0.07961949706077576,
0.7263169884681702,
-0.11858898401260376,
-0.44132301211357117,
0.10518622398376465,
0.011067005805671215,
-0.0645391121506691,
-0.2670866847038269,
-0.5961756706237793,
-0.0764690712094307,
-0.536903977394104,
-0.13166673481464386,
-0.036064136773347855,
0.30640459060668945,
0.3800818622112274,
0.4171140193939209,
-0.08164041489362717,
-0.5352894067764282,
-0.17289946973323822,
0.17168183624744415,
-0.5564746856689453,
0.3673035204410553,
0.48535165190696716,
1.0708905458450317,
0.2103092074394226,
-0.09101635217666626,
0.35403022170066833,
-0.32977795600891113,
-0.043762821704149246,
0.7146576642990112,
-0.8256391286849976,
1.3582032918930054,
-0.021937014535069466,
0.05536516010761261,
0.5814943909645081,
0.310076504945755,
0.18246129155158997,
0.04344876483082771,
0.6496886610984802,
0.38736364245414734,
-0.3636196553707123,
-0.7877429723739624,
-0.05064478516578674,
0.19643712043762207,
-0.39128848910331726,
-0.31491169333457947,
0.32478657364845276,
0.27054694294929504,
-0.7913051247596741,
-0.3286096751689911,
-0.013932907953858376,
-0.18407443165779114,
-0.26136672496795654,
0.3323163390159607,
0.4019756317138672,
0.2419857680797577,
-0.43338707089424133,
-0.3673624098300934,
-0.5265942215919495,
0.23045450448989868,
0.279469758272171,
0.09156351536512375,
0.9807561039924622,
-0.1544029861688614,
-0.14648538827896118,
0.2358071208000183,
-0.2809945344924927,
0.3810294270515442,
0.16042368113994598,
0.320395290851593,
-0.2256569266319275,
0.1698261797428131,
0.1685865819454193,
-0.282045841217041,
-0.34373122453689575,
0.13561180233955383,
-0.13843543827533722,
0.32805293798446655,
0.15792304277420044,
-0.5859810709953308,
0.3656557500362396,
0.2554192841053009,
0.11755222082138062,
0.3336775004863739,
0.5049857497215271,
-0.8701148629188538,
-0.30356094241142273,
0.05355957895517349,
0.10462984442710876,
0.25648555159568787,
-0.25619301199913025,
0.007037783972918987,
0.07572881877422333,
-0.26891323924064636,
-0.4706806242465973,
-0.11011356860399246,
-0.20901744067668915,
-0.6983311176300049,
0.2216072678565979,
0.2781909108161926,
-0.012311575002968311,
-0.08418625593185425,
-0.8383384346961975,
-0.7609227895736694,
-0.06365879625082016,
0.608947217464447,
0.6296505928039551,
0.5073148012161255,
-0.3853830397129059,
-0.7539399266242981,
0.018563488498330116,
0.17146502435207367,
-0.5951960682868958,
-0.060571860522031784,
0.746387243270874,
-0.6648651361465454,
-0.7076734900474548,
0.22327086329460144,
0.9873805642127991,
0.7171290516853333,
-0.4366461932659149,
-0.6097157597541809,
0.008147617802023888,
-0.719861626625061,
-0.6834365725517273,
0.15520954132080078,
-0.596798300743103,
0.373936265707016,
0.3103767931461334,
-0.23457646369934082,
-0.5121126174926758,
0.10707224160432816,
0.0124618886038661,
-0.2939274311065674,
0.7762396931648254,
0.44920894503593445,
0.3879138231277466,
-0.3367219567298889,
0.02139449119567871,
-0.07724706828594208,
0.027564769610762596,
0.3140927255153656,
-0.19747185707092285,
-0.4660576283931732,
0.1728210598230362,
-5.910135746002197,
-0.2011573612689972,
-0.18107804656028748,
-0.06359108537435532,
0.29802626371383667,
0.27132439613342285,
0.8823376297950745,
-0.14369399845600128,
0.1640789955854416,
0.22643190622329712,
0.1719152182340622,
0.47983697056770325,
0.37306421995162964,
-0.11584679037332535,
0.3443344831466675,
0.012608855031430721,
0.22407567501068115,
-0.7229565382003784,
0.9383936524391174,
0.019589219242334366,
0.7450332641601562,
-0.19575229287147522,
-0.13851626217365265,
0.4009408950805664,
0.1554725170135498,
0.09726335853338242,
-0.9019789099693298,
0.5342852473258972,
-0.7189637422561646,
-0.2222745716571808,
0.19751645624637604,
-0.4595191776752472,
-0.3919277489185333,
-0.1455073207616806,
0.23010514676570892,
-0.23520371317863464,
0.4604875147342682,
-0.4309099018573761,
-0.650017499923706,
-0.7242600917816162,
0.02480202354490757,
0.21064230799674988,
0.025549612939357758,
-0.7745866179466248,
0.24624864757061005,
0.12731778621673584,
0.21327395737171173,
-0.11085639148950577,
0.16588467359542847,
0.39339256286621094,
0.3329399526119232,
-0.14229953289031982,
-0.18391141295433044,
-0.21332469582557678,
-0.15602193772792816,
-0.07319571822881699,
0.016988229006528854,
0.2663785219192505,
-0.27351054549217224,
0.16122272610664368,
0.3804898262023926,
0.04444615915417671,
-0.18130545318126678,
-0.5524697303771973,
-0.13187137246131897,
0.09194311499595642,
-0.10861488431692123,
-0.28630292415618896,
0.2561911344528198,
0.1306411474943161,
-0.2739390730857849,
0.32172757387161255,
0.06866611540317535,
-0.6622035503387451,
0.2498331367969513,
-0.28026869893074036,
0.5279690623283386,
0.14062535762786865,
-0.28296345472335815,
-0.11961348354816437,
-0.20093005895614624,
-0.5793469548225403,
0.3246554732322693,
0.08426341414451599,
0.35004353523254395,
-0.07363104075193405,
-0.30223721265792847,
0.44871488213539124,
-0.004176803398877382,
0.24611251056194305,
0.35230064392089844,
-0.3929380476474762,
0.07829079031944275,
0.7865629196166992,
-0.43355149030685425,
0.6162095665931702,
0.3019580841064453,
0.7593098878860474,
0.27307623624801636,
0.2138553410768509,
0.0024100446607917547,
0.27974140644073486,
-0.023058351129293442,
-0.6812452077865601,
-0.035405270755290985,
-0.10235895961523056,
-0.353729248046875,
-0.28740671277046204,
0.3930847644805908,
-0.527922511100769,
0.11205597966909409,
0.08568909764289856,
-0.20102405548095703,
0.37133756279945374,
0.7245774865150452,
-0.23530934751033783,
-0.011138522066175938,
-0.05391862243413925,
0.6587218046188354,
-0.2950182259082794,
-0.10758402198553085,
0.5580765008926392,
-0.9661281108856201,
0.45358914136886597,
-0.11103742569684982,
-0.4324212372303009,
0.1871975064277649,
0.7422981858253479,
-0.625744640827179,
0.28430667519569397,
-0.06857508420944214,
0.269819438457489,
-0.2214183509349823,
-0.39329442381858826,
0.44608092308044434,
-0.37956327199935913,
-0.8025700449943542,
0.6357602477073669,
-0.07419535517692566,
0.35131746530532837,
0.22851863503456116,
-0.20377258956432343,
-0.13049231469631195,
-0.12937292456626892,
0.42412567138671875,
0.08420269936323166,
0.25067901611328125,
-0.008887840434908867,
-0.1792430579662323,
0.3088741600513458,
0.5392729640007019,
-0.09350770711898804,
0.018933748826384544,
0.1765470802783966,
0.018788358196616173,
0.11888334900140762,
0.9081923961639404,
0.207545205950737,
-0.05355529859662056,
-0.5775576829910278,
-0.1068444475531578,
0.18797248601913452,
-1.3669143915176392,
-0.33113694190979004,
0.22505120933055878,
-0.4223518371582031,
-0.25258636474609375,
-0.061623234301805496,
0.12841208279132843,
0.12577494978904724,
-0.23465415835380554,
-0.6503910422325134,
0.11125938594341278,
0.2634751498699188,
0.3762204349040985,
0.3341142237186432,
-0.2943665683269501,
-0.14031386375427246,
-0.468569278717041,
0.13138461112976074,
0.2759358286857605,
-0.38989710807800293,
-0.04650215059518814,
-0.02884158119559288,
0.44340020418167114,
0.14719831943511963,
-0.661912202835083,
-0.18559421598911285,
-0.5169886350631714,
-0.21682600677013397,
0.1288428157567978,
-0.022821146994829178,
0.2695990800857544,
0.4024892747402191,
-0.09835509955883026,
-0.48996731638908386,
0.02208753675222397,
0.6232590675354004,
-0.09540031105279922,
-0.14798159897327423,
0.33558112382888794,
0.8860214948654175,
-0.09067286550998688,
0.09055148810148239,
0.32455161213874817,
-0.4008968472480774,
-0.6676580309867859,
0.05869003385305405,
-0.39240938425064087,
-0.5039258599281311,
0.02961243875324726,
-0.5274748206138611,
-0.17701803147792816,
0.22339706122875214,
-0.28609901666641235,
0.11431518197059631,
0.7392663955688477,
-0.4045085906982422,
0.350774347782135,
0.050411373376846313,
0.48736900091171265,
-0.3399282395839691,
-0.19828394055366516,
0.02751702256500721,
-0.6495661735534668,
0.019251948222517967,
0.5504525899887085,
-0.5030404329299927,
0.05922845005989075,
-0.03339186683297157,
-0.3332439064979553,
-0.21851874887943268,
-0.22496537864208221,
0.22546164691448212,
-0.11004076898097992,
-0.14901196956634521,
-0.5082150101661682,
0.229446679353714,
-0.03379664942622185,
0.10789378732442856,
-0.1317112147808075,
0.4160539507865906,
-0.13155215978622437,
0.21173937618732452,
-0.4252421259880066,
0.07585866004228592,
0.6328791379928589,
-0.33848193287849426,
0.1559230387210846,
0.17739556729793549,
0.1526934653520584,
-0.2461290955543518,
0.10817861557006836,
-0.10851939767599106,
0.6977823972702026,
0.0560372956097126,
-0.03367358073592186,
-0.8585717678070068,
-0.15749900043010712,
0.30306926369667053,
-0.18445701897144318,
0.5349283218383789,
-0.8280690312385559,
-0.197230264544487,
-0.15928246080875397,
0.4539376199245453,
-0.3075922727584839,
-0.14303797483444214,
0.14211289584636688,
-0.48699554800987244,
-0.24027901887893677,
0.4997698664665222,
0.15806548297405243,
0.9577304124832153,
0.051785510033369064,
0.3254886567592621,
-0.3108910024166107,
-0.22449298202991486,
0.5426235198974609,
0.2766380310058594,
-0.3149424195289612,
-0.2616260349750519,
0.627917468547821,
-0.5018418431282043,
-0.21034492552280426,
-0.8420908451080322,
-0.09784962236881256,
-0.511513352394104,
-0.5803656578063965,
-0.4016963541507721,
0.19280749559402466,
0.6234161257743835,
-0.7168033123016357,
-0.23693256080150604,
-0.2305225282907486,
-0.0063378941267728806,
0.06175466254353523,
0.5620809197425842,
-0.014607406221330166,
0.014882602728903294,
-0.40389466285705566,
-0.08385301381349564,
0.5153895020484924,
-0.2244679033756256,
-0.3130853474140167,
0.29077547788619995,
0.6377275586128235,
-0.4285581409931183,
0.06662911921739578,
-0.05414688587188721,
0.32109999656677246,
-0.07287902384996414,
0.13343827426433563,
0.30880653858184814,
-0.7053886651992798,
0.07036935538053513,
0.24388793110847473,
0.06914589554071426,
-0.25581035017967224,
0.2358795553445816,
0.4613801836967468,
0.7346920967102051,
0.6124349236488342,
-0.24067345261573792,
-0.17668962478637695,
0.38162845373153687,
0.1735347956418991,
0.20144467055797577,
-0.17036214470863342,
0.16781853139400482,
0.5234519243240356,
0.6062011122703552,
0.03486623987555504,
0.49486786127090454,
0.1347021907567978,
0.46855565905570984,
-0.26228368282318115,
-0.09896141290664673,
-0.12247622758150101,
-0.33837366104125977,
1.0466398000717163,
-0.23868274688720703,
-0.1898999661207199,
-0.25548991560935974,
0.7114654183387756,
0.43131324648857117,
0.20347116887569427,
-0.522458553314209,
0.2095966637134552,
0.038246192038059235,
0.015578403137624264,
0.11382446438074112,
-0.39831727743148804,
-0.15963342785835266,
-0.44641730189323425,
0.09476567804813385,
0.5146540999412537,
-0.1447257101535797,
-0.5839818120002747,
0.45011040568351746,
-0.25415337085723877,
0.0056115626357495785,
-0.02586081251502037,
0.48950231075286865,
-0.33275219798088074,
-0.23519542813301086,
0.3118126094341278,
0.45209136605262756,
0.05771666765213013,
0.24421194195747375,
-0.14909587800502777,
-0.40389108657836914,
-0.6889116168022156,
0.5814844369888306,
0.13569298386573792,
-0.6368762254714966,
0.39287665486335754,
-0.005444425158202648,
0.04771069437265396,
-0.020390113815665245,
-0.450641930103302,
0.22789160907268524,
-0.6741396188735962,
-0.9262023568153381,
-0.36059439182281494,
0.14026466012001038,
-0.2982259690761566,
-0.14785940945148468,
-0.03165438398718834,
0.03120208904147148,
0.37867093086242676,
-0.38417378067970276,
-0.11136479675769806,
0.11096793413162231,
-0.1565152108669281,
-0.5933820605278015,
-0.17148247361183167,
0.33143526315689087,
-0.009876754134893417,
0.32392674684524536,
0.21407227218151093,
0.3017825484275818,
-0.29787445068359375,
0.7351529002189636,
0.15762965381145477,
0.4184872806072235,
-0.6149018406867981,
0.44447484612464905,
-0.5578023791313171,
0.09260603040456772,
0.692410945892334,
0.4730018973350525,
-0.24685631692409515,
0.21531254053115845,
-0.29377326369285583,
-0.43100807070732117,
0.4425189793109894,
-0.5643186569213867,
-0.14583690464496613,
-0.3457961082458496,
-0.3944341242313385,
0.16417913138866425,
0.5188981890678406,
-0.33661720156669617,
-0.6632423400878906,
0.3031404912471771,
0.4907979667186737,
0.20795415341854095,
0.04802446439862251,
0.4438938498497009,
-0.10252293944358826,
0.20635905861854553,
-0.47837647795677185,
0.06737274676561356,
-0.6341066956520081,
-0.2202204316854477,
-0.026506463065743446,
0.45759984850883484,
-0.27351120114326477,
-0.2346508502960205,
-0.268808513879776,
-0.2123660147190094,
0.3566392660140991,
0.01242477260529995,
-0.11882644891738892,
-0.29517751932144165,
0.20179370045661926,
-0.5629791021347046,
-0.9588133692741394,
0.022117532789707184,
-0.2104482799768448,
-0.2446008324623108,
-0.9279005527496338,
-0.004945531487464905,
0.10532164573669434,
-0.5811523199081421,
-0.10063163936138153,
-0.5607557892799377,
-0.13832232356071472,
-0.15946164727210999
] |
Chromosome numbers from meiotic studies have been reported for the following species ofUtricularia: U. aurea Lour. (n=21);U. baouleënsis A. Chev. (n=10);U. caerulea L. (n=20);U. inflexa var.stellaris (Linn.f.) P. Taylor (n=21);U. minutissima Vahl (n=8);U. scandens Benj. (n=6, 7); andU. stricticaulis Stapf (n=7). There are two cyto-races inU. scandens. | [
-0.0037781563587486744,
-0.0027950764633715153,
-0.01294778659939766,
0.022721299901604652,
0.026094578206539154,
0.0062832217663526535,
0.006338619627058506,
-0.002420667326077819,
-0.011915775947272778,
-0.023297689855098724,
0.012391279451549053,
-0.0016049934783950448,
-0.020272420719265938,
0.0026333944406360388,
-0.003014366375282407,
-0.006622389890253544,
-0.04203055053949356,
0.017428765073418617,
0.008396022021770477,
-0.009032230824232101,
0.009377548471093178,
-0.013147303834557533,
0.005897323600947857,
0.010503904893994331,
0.010299984365701675,
0.0019800085574388504,
0.007874200120568275,
-0.005348365753889084,
-0.0045841773971915245,
-0.007867250591516495,
0.006277300883084536,
-0.003948475234210491,
-0.004351034294813871,
0.009683020412921906,
0.015048198401927948,
-0.0003533971030265093,
-0.01002945750951767,
0.01926354132592678,
0.03166954219341278,
-0.0026418552733957767,
-0.009287366643548012,
-0.012888009659945965,
0.0027777310460805893,
-0.0038456772454082966,
-0.005955074913799763,
0.006351221352815628,
-0.008715489879250526,
-0.0026651062071323395,
0.012501757591962814,
0.002317270962521434,
-0.0021989354863762856,
0.020985260605812073,
-0.012894873507320881,
0.006524641066789627,
-0.003542250255122781,
0.0013578315265476704,
0.013637842610478401,
0.011384114623069763,
-0.008171171881258488,
0.013671951368451118,
-0.009159717708826065,
-0.005617705173790455,
0.005778673104941845,
-0.002525459509342909,
-0.005550767760723829,
-0.06763897836208344,
0.011866362765431404,
0.006578224245458841,
0.0012103852350264788,
-0.013957006856799126,
-0.01020244974642992,
0.011727845296263695,
-0.00026149372570216656,
-0.009388783946633339,
-0.004770680796355009,
-0.009233679622411728,
-0.015649713575839996,
0.014939429238438606,
0.0016221078112721443,
-0.006021438632160425,
0.011582514271140099,
-0.003546814201399684,
0.01128050684928894,
-0.0010637370869517326,
0.005734742619097233,
0.00470741419121623,
-0.012373808771371841,
0.014292946085333824,
0.029806148260831833,
0.003998557571321726,
0.0007289685308933258,
0.007205423433333635,
-0.01615701988339424,
0.0003656754270195961,
-0.005220487713813782,
-0.025711026042699814,
-0.025497209280729294,
-0.007540667429566383,
0.000004531349986791611,
-0.014994803816080093,
-0.0004686362808570266,
-0.005420765373855829,
0.002666208427399397,
0.020878026261925697,
-0.007451785262674093,
0.005306757986545563,
-0.008176557719707489,
0.006646967027336359,
0.013317052274942398,
0.005190971307456493,
-0.011645030230283737,
0.012029122561216354,
0.0001472915173508227,
-0.012067917734384537,
0.017971141263842583,
-0.00742664560675621,
0.003353031584993005,
-0.008184816688299179,
0.00015816825907677412,
-0.0014667920768260956,
-0.002877253107726574,
-0.010999273508787155,
-0.0031168805435299873,
0.010585938580334187,
0.0042704930528998375,
-0.0025244709104299545,
-0.008442722260951996,
-0.02149248868227005,
0.025464558973908424,
0.006073878612369299,
-0.0010070870630443096,
0.002390477107837796,
0.017115354537963867,
0.006399872247129679,
-0.01738474890589714,
-0.0014433590695261955,
-0.004230953752994537,
0.013614673167467117,
-0.0161708015948534,
-0.03425005078315735,
-0.004156270995736122,
0.010972408577799797,
0.003618431743234396,
-0.0012094385456293821,
0.005395371001213789,
-0.005563330836594105,
-0.019227460026741028,
-0.007111186161637306,
-0.017413482069969177,
-0.01145759504288435,
0.009638750925660133,
-0.02637522481381893,
-0.007580928038805723,
-0.008401099592447281,
0.015720540657639503,
0.012557463720440865,
-0.005670545157045126,
-0.01152860838919878,
0.00883076898753643,
0.011709259822964668,
0.00143837567884475,
-0.002637101337313652,
0.01609867997467518,
0.008290670812129974,
0.01047295331954956,
0.0075995526276528835,
-0.007678578142076731,
0.011531985364854336,
-0.021423550322651863,
0.0007492187432944775,
-0.004597704391926527,
0.011688563972711563,
0.016426395624876022,
0.007101600989699364,
0.020137473940849304,
0.0019777603447437286,
0.007681238930672407,
0.00142033607698977,
0.0013290259521454573,
0.0668954849243164,
-0.01294736098498106,
0.0005757163744419813,
0.0034896559081971645,
-0.019982581958174706,
-0.0068249888718128204,
-0.0105773089453578,
-0.012893743813037872,
-0.004595454316586256,
-0.0019531119614839554,
-0.018115807324647903,
0.010724900290369987,
-0.01805102452635765,
-0.0008597574196755886,
-0.0034511385019868612,
-0.015555053949356079,
0.0013322471641004086,
0.01252090185880661,
0.01225945632904768,
0.0031550091225653887,
0.007607159670442343,
-0.020941665396094322,
0.00954454019665718,
-0.018160078674554825,
-0.004053855314850807,
0.003924615681171417,
0.002057849895209074,
-0.004251303616911173,
0.00856146588921547,
-0.005544349551200867,
0.013381792232394218,
-0.005930154584348202,
0.01338464766740799,
-0.012249795719981194,
-0.006909440271556377,
0.0177999809384346,
0.007386243902146816,
0.0028964411467313766,
0.007395932916551828,
-0.020106572657823563,
-0.014522387646138668,
0.0005885435966774821,
0.013216076418757439,
0.011189843527972698,
-0.006269063800573349,
-0.001077465247362852,
-0.04011119157075882,
0.010361643508076668,
0.004382675513625145,
-0.0016613237094134092,
-0.00247582676820457,
-0.015273417346179485,
-0.016093067824840546,
-0.010070350021123886,
0.020987853407859802,
-0.014503921382129192,
-0.0018931194208562374,
0.009149438701570034,
-0.009387701749801636,
-0.00037885113852098584,
0.0018604705110192299,
-0.0014489770401269197,
-0.009646603837609291,
0.021999023854732513,
-0.02304413914680481,
0.006103714928030968,
-0.004842165391892195,
0.023456642404198647,
0.010821178555488586,
0.019987326115369797,
-0.006619064137339592,
0.005688240751624107,
0.010140493512153625,
-0.009930441156029701,
0.01566510647535324,
-0.004165820777416229,
0.004694540984928608,
-0.006929908879101276,
0.01523774117231369,
0.02224903181195259,
-0.0033215759322047234,
0.009164048358798027,
-0.0022459477186203003,
-0.0035622981376945972,
-0.0017784067895263433,
0.007737697567790747,
0.0006615854799747467,
0.00767055107280612,
0.017189476639032364,
0.02151055820286274,
0.01405099406838417,
0.005247969646006823,
-0.0035257646813988686,
0.0019476779270917177,
-0.0823320746421814,
-0.0004117656499147415,
-0.00867395382374525,
-0.008606227114796638,
0.006281865295022726,
0.031109429895877838,
-0.0060621206648647785,
0.015655964612960815,
0.0031213178299367428,
0.018483974039554596,
0.013943124562501907,
-0.0011088880710303783,
-0.009729456156492233,
0.0099581778049469,
0.003114584367722273,
-0.002892977325245738,
0.006910383235663176,
-0.014522282406687737,
-0.03297585994005203,
-0.03349892795085907,
-0.007697543129324913,
-0.01643282175064087,
-0.002216991037130356,
0.014490563422441483,
0.019006112590432167,
-0.01713491976261139,
0.0031162104569375515,
0.01531330868601799,
-0.0054392945021390915,
-0.013625040650367737,
-0.002979564480483532,
-0.0019834900740534067,
-0.006097696255892515,
0.006371850147843361,
0.004017526283860207,
0.02002277784049511,
0.00895705446600914,
0.00937972217798233,
-0.006285254843533039,
-0.0031413547694683075,
-0.015349922701716423,
0.006093885283917189,
0.010450339876115322,
-0.011275947093963623,
0.007112292572855949,
0.0005725688533857465,
0.011330150067806244,
-0.003939400427043438,
0.02122964709997177,
0.010973602533340454,
-0.024083945900201797,
-0.0022883391939103603,
0.013454635627567768,
0.012659993022680283,
-0.004097901750355959,
0.01153607852756977,
-0.011802167631685734,
-0.003203100059181452,
-0.010594405233860016,
-0.004643805790692568,
0.026537302881479263,
-0.002382802776992321,
0.04132036119699478,
0.009265631437301636,
0.004260004032403231,
0.010947678238153458,
0.0007390233804471791,
-0.0006501516327261925,
-0.006230510305613279,
0.0036937075201421976,
0.007815267890691757,
-0.0063636647537350655,
-0.008855211548507214,
-0.0027553318068385124,
0.008805324323475361,
-0.006924950517714024,
-0.007096652407199144,
-0.012114383280277252,
0.0003935275599360466,
0.011897246353328228,
-0.01085541769862175,
-0.0010697052348405123,
0.009506694972515106,
-0.002460378920659423,
-0.019685205072164536,
-0.00144621089566499,
0.007887227460741997,
0.020228739827871323,
0.011124804615974426,
-0.005055015906691551,
0.024214647710323334,
0.007039868738502264,
0.015494896098971367,
0.010172221809625626,
-0.00934354867786169,
0.005440038628876209,
0.010228097438812256,
0.008153257891535759,
-0.0006753068882972002,
0.0036508655175566673,
0.0048544807359576225,
-0.0018265191465616226,
-0.009449442848563194,
0.0015630214475095272,
-0.019536539912223816,
0.011393846943974495,
-0.008289591409265995,
-0.009074077941477299,
-0.009192761965095997,
0.002670218935236335,
0.026181437075138092,
0.009852452203631401,
-0.0012281998060643673,
0.018720868974924088,
-0.003775102086365223,
0.004013530910015106,
-0.012134893797338009,
-0.011981025338172913,
0.07414186745882034,
-0.013862844556570053,
-0.0020836966577917337,
-0.0028566059190779924,
-0.023751627653837204,
-0.006064453162252903,
-0.0031349482014775276,
-0.004323416389524937,
-0.01714581623673439,
0.00222769845277071,
0.009822340682148933,
-0.013344919309020042,
-0.004972230643033981,
-0.005250784568488598,
-0.009506488218903542,
0.0013162530958652496,
0.007324639242142439,
-0.012736406177282333,
0.005998463369905949,
0.007530957460403442,
-0.019553113728761673,
0.010011618956923485,
-0.013569485396146774,
-0.01210617646574974,
0.03390340134501457,
-0.0009783587884157896,
-0.023266099393367767,
-0.01097884587943554,
-0.008368386887013912,
0.007372298743575811,
0.006583652459084988,
0.00419872161000967,
-0.00988006591796875,
-0.010064693167805672,
0.014099892228841782,
-0.006310337223112583,
0.0007235598750412464,
0.01966942846775055,
0.009176399558782578,
-0.0056254006922245026,
-0.0003416260005906224,
-0.002659679390490055,
0.007661617826670408,
-0.004709725268185139,
0.0033682461362332106,
-0.013978182338178158,
0.00918983668088913,
-0.004993688315153122,
-0.00833086483180523,
-0.00384370144456625,
0.005874630995094776,
0.005025466904044151,
0.013965170830488205,
-0.00617268355563283,
-0.00007028505206108093,
-0.013434013351798058,
0.008459296077489853,
-0.007527843117713928,
-0.014071683399379253,
0.006413585506379604,
-0.00005121738649904728,
0.0027502994053065777,
-0.0008797370828688145,
-0.0064888824708759785,
-0.00011918973177671432,
-0.005267792381346226,
-0.005690496414899826,
0.004848610609769821,
0.017218410968780518,
-0.007931048981845379,
0.0005706772208213806,
-0.005614059045910835,
0.0035972008481621742,
0.004747346043586731,
-0.01117852982133627,
-0.012359276413917542,
-0.011448703706264496,
0.005035256966948509,
-0.0037688114680349827,
-0.0024953384418040514,
-0.012158116325736046,
0.0029694316908717155,
-0.00014174822717905045,
0.01744925230741501,
0.021474555134773254,
-0.04038505628705025,
-0.025943506509065628,
-0.07635261118412018,
-0.02059035561978817,
-0.0048058656975626945,
-0.0018125672359019518,
0.009085957892239094,
0.009715007618069649,
-0.026500292122364044,
0.019396718591451645,
0.0005216954741626978,
-0.009787440299987793,
-0.0017452528700232506,
0.0004617664963006973,
0.0017835170729085803,
0.0007918775081634521,
0.007117840927094221,
-0.012301595881581306,
0.0036254834849387407,
0.0022597634233534336,
-0.012335296720266342,
0.013576237484812737,
0.017277173697948456,
0.009968525730073452,
-0.016650229692459106,
-0.011105440557003021,
-0.004991504363715649,
-0.08279021084308624,
-0.01046864502131939,
0.014449172653257847,
0.004013309255242348,
-0.015511788427829742,
0.009881531819701195,
0.0028823900502175093,
0.005156610161066055,
-0.023251909762620926,
-0.013584792613983154,
-0.0030109321232885122,
-0.008642574772238731,
-0.007369043305516243,
-0.010180686600506306,
-0.0072804950177669525,
-0.001488574082031846,
0.014017168432474136,
-0.025514481589198112,
-0.02238614484667778,
0.019831303507089615,
0.0002403216203674674,
0.0017696100985631347,
-0.0016798211727291346,
-0.004254192113876343,
-0.0017883176915347576,
0.01204197108745575,
-0.021121228113770485,
0.007519654929637909,
-0.00810866616666317,
-0.009553606621921062,
-0.0015987693332135677,
-0.0037229093722999096,
-0.013314330950379372,
-0.00548804085701704,
0.0020066627766937017,
-0.009775638580322266,
0.015596602112054825,
-0.00756628205999732,
-0.006661492399871349,
-0.004374039359390736,
0.0002928697504103184,
0.0015691355802118778,
0.0030526560731232166,
-0.0027455424424260855,
0.006375174969434738,
-0.01016710139811039,
0.008039074018597603,
-0.010757270269095898,
-0.003712860168889165,
0.002555905608460307,
0.015853138640522957,
0.0011768259573727846,
-0.013741154223680496,
0.019176822155714035,
-0.010977070778608322,
-0.0034535331651568413,
0.0008264647331088781,
0.011953534558415413,
-0.019308559596538544,
-0.0004827096126973629,
0.014891945756971836,
0.016439922153949738,
-0.0007351550739258528,
0.07218040525913239,
0.009528462775051594,
-0.007566275540739298,
0.008795611560344696,
-0.008332811295986176,
0.0027778411749750376,
-0.007000109180808067,
0.0022168555296957493,
-0.03304499760270119,
-0.011301569640636444,
-0.003988795448094606,
0.0007146825082600117,
0.013539617881178856,
0.010059532709419727,
0.00836215354502201,
0.00381455454044044,
-0.03597310930490494,
0.01708541065454483,
-0.003190070390701294,
-0.004500234499573708,
0.005486157722771168,
0.014057922177016735,
0.009668048471212387,
-0.020834986120462418,
-0.02482576109468937,
-0.016780149191617966,
0.005882070399820805,
0.026955366134643555,
0.0004958761855959892,
0.013268268667161465,
-0.018535256385803223,
-0.029313772916793823,
0.011619405820965767,
0.011036816984415054,
-0.00647412333637476,
-0.00568002462387085,
-0.009930495172739029,
0.01427073497325182,
-0.010648904368281364,
-0.012728195637464523,
0.003756637219339609,
-0.014805438928306103,
0.007505113258957863,
0.007933953776955605,
0.015352275222539902,
-0.00403391569852829,
0.0019801645539700985,
0.02139771729707718,
-0.0011625578626990318,
-0.0011882670223712921,
-0.011703141033649445,
0.014939283020794392,
-0.009860078804194927,
-0.012222044169902802,
0.00021591514814645052,
0.0051734973676502705,
-0.006865891627967358,
0.019605416804552078,
-0.0015704986872151494,
0.011095887050032616,
0.018704667687416077,
0.0034246938303112984,
-0.005367708392441273,
-0.007517235353589058,
-0.002878489438444376,
-0.014063062146306038,
0.005227903835475445,
-0.018457310274243355,
-0.01432359404861927,
0.011236277408897877,
-0.006330942735075951,
0.017467398196458817,
0.002294060541316867,
-0.00014236196875572205,
-0.00785926915705204,
0.014867844991385937,
-0.019200310111045837,
0.004263290204107761,
0.007814434356987476,
0.02465086057782173,
-0.009137848392128944,
-0.0002541881985962391,
-0.01682966575026512,
-0.00775068299844861,
-0.006046664901077747,
-0.0013281109277158976,
0.010669201612472534,
0.03356268256902695,
0.0031375964172184467,
-0.001000907621346414,
0.020443692803382874,
0.004038407001644373,
-0.005134371109306812,
0.024952590465545654,
0.0007028126856312156,
0.03349392116069794,
-0.0030933967791497707,
0.006784974131733179,
0.00105857546441257,
0.0037975842133164406,
0.01481268834322691,
0.0026202364824712276,
-0.00020897143986076117,
0.011616474017500877,
0.0029255645349621773,
-0.0041249520145356655,
-0.01066293753683567,
0.02429398149251938,
0.014211350120604038,
0.0064142076298594475,
0.01165116485208273,
-0.011180458590388298,
-0.011360326781868935,
0.004607755690813065,
0.0008952917414717376,
-0.011228011921048164,
-0.0019896086305379868,
-0.013697341084480286,
-0.006646670401096344,
-0.015217561274766922,
-0.002433840651065111,
-0.009600045159459114,
-0.018036451190710068,
0.024543248116970062,
-0.0005194670520722866,
-0.01391471829265356,
-0.004661327227950096,
0.021168097853660583,
-0.001777698053047061,
-0.009268008172512054,
0.015411020256578922,
0.013942154124379158,
-0.018126435577869415,
-0.007014704402536154,
0.003611357882618904,
-0.0031421100720763206,
-0.0006251560407690704,
0.007590295746922493,
0.00910109095275402,
-0.017682306468486786,
0.0027192607522010803,
-0.0028681885451078415,
0.0029841933865100145,
-0.012510906904935837,
0.008357862010598183,
0.0019177556969225407,
-0.014252394437789917,
0.010179915465414524,
-0.0002901992993429303,
-0.010250745341181755,
-0.006305778864771128,
-0.004664132371544838,
-0.004599080421030521,
-0.0031346851028501987,
-0.005213556811213493,
0.0028860033489763737,
0.008823292329907417,
0.003056944813579321,
0.012065359391272068,
-0.0005494006909430027,
-0.004007895011454821,
0.010998871177434921,
0.008607913739979267,
-0.0057876394130289555,
0.01816871389746666,
-0.010543180629611015,
0.008490314707159996,
-0.003930254839360714,
-0.019937610253691673,
-0.01462395116686821,
0.028764884918928146,
-0.014578635804355145,
0.002373842755332589,
0.017493274062871933,
-0.009640245698392391,
0.011464061215519905,
-0.00569399818778038,
0.015239164233207703,
-0.016199730336666107,
-0.0056336065754294395,
-0.0035741659812629223,
-0.010391997173428535,
0.002745090052485466,
0.00028699933318421245,
0.008971542119979858,
-0.016797319054603577,
0.0043684630654752254,
-0.0024748349096626043,
-0.007345536723732948,
-0.00704502547159791,
-0.011164437979459763,
-0.004865571856498718,
0.006105656735599041,
0.008423001505434513,
0.002056211233139038,
0.015489228069782257,
0.00223833741620183,
-0.005398433655500412,
-0.0005266254302114248,
-0.014950297772884369,
0.012231853790581226,
-0.009270021691918373
] | [
-0.09520366787910461,
0.26978468894958496,
0.33210164308547974,
0.006358151789754629,
-0.12807461619377136,
0.6424981355667114,
0.3960825800895691,
0.35290083289146423,
-0.08174971491098404,
-0.47982257604599,
-0.0754658654332161,
-0.4173358976840973,
-0.6527325510978699,
0.5809459090232849,
-0.13314931094646454,
1.2355684041976929,
-0.25067320466041565,
0.7851238250732422,
-0.3096286952495575,
-0.6335420608520508,
0.15754573047161102,
-0.6529917120933533,
0.3898821473121643,
-0.3324291706085205,
-0.05541500449180603,
-0.2932402789592743,
0.11375899612903595,
0.22821274399757385,
0.39342474937438965,
-0.0007550259470008314,
-0.07031392306089401,
0.5817185640335083,
0.9129214286804199,
0.40480348467826843,
0.006341190077364445,
-0.3942194879055023,
0.7335449457168579,
-0.16034650802612305,
0.7687355875968933,
-0.49028900265693665,
0.14885132014751434,
-0.9297712445259094,
0.3283403813838959,
-0.07889910787343979,
-0.6751480102539062,
-0.45647284388542175,
-1.3012044429779053,
1.0311416387557983,
-0.1572589874267578,
-0.13406284153461456,
-0.0907544493675232,
-0.30302754044532776,
0.6857986450195312,
0.09294184297323227,
0.3301279544830322,
0.35901355743408203,
-0.4938838481903076,
-0.10798439383506775,
0.7414155602455139,
-0.664556622505188,
0.06775332987308502,
0.09913770854473114,
0.33888083696365356,
0.5165268182754517,
-0.0463421605527401,
0.38450944423675537,
0.01597260683774948,
-0.2268291562795639,
-0.6031269431114197,
-0.7332019805908203,
0.43697863817214966,
0.21070964634418488,
0.28032806515693665,
-0.09784720838069916,
-0.22606399655342102,
-0.03259143978357315,
-0.9514962434768677,
-0.14728987216949463,
0.5374512076377869,
-0.2650357186794281,
-0.30840185284614563,
-0.22738660871982574,
0.6451454162597656,
-0.11150672286748886,
0.2815408706665039,
0.30604735016822815,
-0.5574065446853638,
0.26075467467308044,
-0.5078393816947937,
0.3086436092853546,
-0.26784950494766235,
-0.1174454614520073,
0.4597153067588806,
0.6016910076141357,
-0.12284121662378311,
-0.308138370513916,
-0.030013561248779297,
-0.13005125522613525,
0.42328932881355286,
-0.27510374784469604,
-0.31725290417671204,
-0.007855364121496677,
0.14156509935855865,
-0.6534712314605713,
-0.9404906034469604,
0.06145862117409706,
-0.21621209383010864,
-0.7341594099998474,
-0.32007691264152527,
0.08305349946022034,
-1.0089548826217651,
-0.07764717936515808,
0.19862639904022217,
0.1955624222755432,
0.08935908228158951,
0.2638665735721588,
-0.282385915517807,
-0.5857665538787842,
0.42754703760147095,
0.18004155158996582,
-0.031034018844366074,
0.6469953656196594,
0.14640748500823975,
-0.08167764544487,
0.35961923003196716,
0.5102591514587402,
-0.0963154211640358,
-0.5226067900657654,
-0.37721961736679077,
0.1718478947877884,
0.344199538230896,
0.5191165804862976,
0.061320334672927856,
0.5606328845024109,
0.3268536925315857,
-0.775088369846344,
-0.22827285528182983,
-0.22597938776016235,
0.547548234462738,
0.22488053143024445,
-1.0573285818099976,
-0.5670674443244934,
-0.447959303855896,
-0.28095903992652893,
0.3201056122779846,
-0.21083486080169678,
0.14010147750377655,
0.18140169978141785,
-0.026209738105535507,
0.01468938123434782,
0.1658448725938797,
-0.14046907424926758,
-0.47904521226882935,
-0.14423824846744537,
-0.3655913770198822,
-0.36540913581848145,
0.22509627044200897,
0.1624653935432434,
-0.050079550594091415,
0.17744529247283936,
0.01448619831353426,
0.5799233317375183,
-0.5419008731842041,
0.052197083830833435,
0.2679719626903534,
0.11075686663389206,
0.3083808124065399,
0.8220807313919067,
-0.7828701734542847,
-0.018231380730867386,
-0.10541953146457672,
-0.3312334418296814,
0.6181052327156067,
0.10081484168767929,
-0.9946144223213196,
0.3259945809841156,
-0.04849008098244667,
-0.01240182388573885,
0.1720706969499588,
-0.18415392935276031,
-0.4746813476085663,
0.10691285133361816,
0.41537031531333923,
0.33035600185394287,
-0.12166731059551239,
0.2928352355957031,
-0.37438684701919556,
-0.1710534691810608,
-0.007063858676701784,
0.2804705500602722,
0.0627192035317421,
-0.05405858904123306,
-0.3297556936740875,
-0.35621681809425354,
0.5705797076225281,
-0.1794995665550232,
-0.8007772564888,
0.5808992385864258,
-0.04986191913485527,
0.01347192469984293,
-0.4257928133010864,
0.1142246350646019,
0.6458437442779541,
-0.03170645236968994,
-0.0021608411334455013,
0.3533366620540619,
-0.10455513000488281,
0.21438370645046234,
-0.06078176945447922,
0.22359131276607513,
-0.03586885333061218,
-0.3405351936817169,
-0.03293263912200928,
0.2892923951148987,
-0.13445886969566345,
-0.039811719208955765,
-0.3511357009410858,
-0.1366090327501297,
0.20409251749515533,
-0.17270338535308838,
0.6028780937194824,
-0.3370279371738434,
0.10892260819673538,
0.36466270685195923,
-0.19237712025642395,
0.43283361196517944,
0.7267946004867554,
0.42453983426094055,
0.2000839114189148,
-0.08630622923374176,
0.6088600754737854,
-0.6261056661605835,
0.2889534831047058,
0.21552321314811707,
0.3275863826274872,
0.4717346131801605,
-0.11460185050964355,
-0.09733904898166656,
0.35761162638664246,
-0.25335079431533813,
-0.16676823794841766,
0.48178181052207947,
-0.20440524816513062,
0.16105784475803375,
-0.07603021711111069,
-0.28795093297958374,
-0.10156413912773132,
-0.058662474155426025,
-0.3842918574810028,
0.507485032081604,
0.08747794479131699,
0.11222994327545166,
-0.16206111013889313,
0.11871712654829025,
0.12484268844127655,
0.6671074628829956,
0.3409324586391449,
0.175669327378273,
0.002883918583393097,
0.36880508065223694,
-0.3335632383823395,
-0.45127588510513306,
0.19438327848911285,
0.14051423966884613,
-0.34487253427505493,
-0.21242834627628326,
-0.5536293387413025,
-0.27161839604377747,
1.0106817483901978,
0.3465851843357086,
-0.09418018907308578,
0.2899402976036072,
-0.5821120738983154,
0.014206026680767536,
-0.3050454258918762,
-0.3434079885482788,
-0.7383949160575867,
0.06249113008379936,
-1.115243673324585,
-0.1568811535835266,
-0.25407981872558594,
0.051254499703645706,
0.07643090188503265,
-0.19123491644859314,
-0.09138504415750504,
-0.2196110635995865,
0.6978116631507874,
-0.6127873659133911,
0.19717879593372345,
-0.7948030829429626,
-0.456911563873291,
0.7584834694862366,
-0.030896557494997978,
-0.20388562977313995,
-0.1222759485244751,
0.09131502360105515,
0.3081912398338318,
0.5234416723251343,
0.3529636263847351,
-0.029656099155545235,
-0.355238676071167,
0.21550491452217102,
0.12256753444671631,
-0.25334596633911133,
-0.004104855470359325,
0.21601834893226624,
0.26457083225250244,
0.2672782242298126,
-5.910844802856445,
0.2460639923810959,
-0.2818899154663086,
0.0270189568400383,
0.11740002036094666,
-0.15427808463573456,
0.5962046384811401,
-0.11857956647872925,
0.13715863227844238,
-0.2566928267478943,
0.8380460143089294,
-0.11612612009048462,
-0.3336436450481415,
0.07953857630491257,
-0.06788770109415054,
0.3628752827644348,
0.17301246523857117,
-0.3585372865200043,
0.18036864697933197,
0.10378590226173401,
-0.20125536620616913,
-0.15791983902454376,
0.37491217255592346,
0.30236098170280457,
-0.04207763820886612,
-0.004010879900306463,
-0.25716519355773926,
-0.2987060844898224,
-0.6243374347686768,
-0.10652633756399155,
-0.28418612480163574,
-0.15685079991817474,
-0.08402185142040253,
-0.16656248271465302,
-0.0339251272380352,
-0.15832625329494476,
0.15908147394657135,
-0.22274790704250336,
0.39367038011550903,
-0.04700016975402832,
0.5105355381965637,
0.4614194929599762,
-0.09045916050672531,
-0.49071377515792847,
-0.23166461288928986,
-0.49325796961784363,
-0.13168852031230927,
0.40422090888023376,
-0.18425296247005463,
0.3078846335411072,
0.042460471391677856,
0.14578089118003845,
0.18743166327476501,
-0.2776753306388855,
0.2224549949169159,
0.07349494844675064,
-0.12431327253580093,
0.2599005699157715,
-0.7146037220954895,
-0.3359602093696594,
0.17598210275173187,
-0.0009601013152860105,
0.1300637125968933,
-0.46747931838035583,
-0.339347243309021,
-0.20583653450012207,
-0.8321441411972046,
0.6562516093254089,
0.6798824667930603,
-0.14319750666618347,
-0.21530091762542725,
-0.26659178733825684,
0.3499707281589508,
-0.6506167650222778,
0.23037350177764893,
-0.7945446372032166,
0.013355105184018612,
-0.010258086025714874,
-0.5699347257614136,
0.3195588290691376,
-0.047441255301237106,
-0.2780701816082001,
0.2651273310184479,
-0.030559705570340157,
0.34200024604797363,
-0.6159203052520752,
-0.17295795679092407,
0.05318944901227951,
-0.12199722230434418,
0.44418415427207947,
0.06201750040054321,
-0.5065435767173767,
0.6138668656349182,
-0.2809915244579315,
0.6054084897041321,
0.5131704807281494,
0.5079309940338135,
0.04698686674237251,
0.23129938542842865,
0.01615086942911148,
0.7803198099136353,
-0.2546587586402893,
0.23268958926200867,
-0.4122294783592224,
0.017856882885098457,
0.06255130469799042,
-0.21128514409065247,
0.3459237515926361,
0.18670962750911713,
-0.18084721267223358,
0.24255897104740143,
-0.27601033449172974,
0.2584819495677948,
-0.1708582490682602,
0.2472643405199051,
-0.11579287797212601,
0.13417364656925201,
0.44483867287635803,
0.7129586935043335,
0.21544647216796875,
-0.43234729766845703,
0.03371875733137131,
-0.7865784168243408,
0.11716736853122711,
0.2701522409915924,
-0.12390480190515518,
-0.24706916511058807,
0.3725610077381134,
-0.4808494746685028,
-0.33582210540771484,
-0.4499654173851013,
0.08807957172393799,
-0.44048359990119934,
-0.1863284558057785,
-0.16448353230953217,
0.13955171406269073,
-0.49343883991241455,
0.49764251708984375,
-0.10839404165744781,
-0.23105309903621674,
-0.11178674548864365,
0.034902289509773254,
-0.3352150022983551,
0.2858258783817291,
-0.041904207319021225,
0.19971907138824463,
0.15639954805374146,
0.07126449793577194,
-0.04887991398572922,
0.1452365219593048,
0.7136845588684082,
-0.6839183568954468,
1.1169955730438232,
-0.1802656501531601,
-0.38609743118286133,
-0.020765384659171104,
0.141557514667511,
0.6113815903663635,
-0.05692823603749275,
-0.35330817103385925,
-0.05121755972504616,
-0.20968908071517944,
-0.45564398169517517,
0.19307251274585724,
-0.21296674013137817,
0.07099045813083649,
0.2858448922634125,
-0.19528375566005707,
-0.60721755027771,
0.45237061381340027,
0.02736666239798069,
0.04273758456110954,
0.18078447878360748,
-0.3089693486690521,
-0.3225160837173462,
0.1266993135213852,
-0.32610082626342773,
-0.2956307828426361,
0.18242532014846802,
-0.10014528036117554,
-0.48613032698631287,
-0.14829663932323456,
0.017987575381994247,
0.5214616060256958,
-0.2835630476474762,
0.358768105506897,
0.22765763103961945,
-0.28565773367881775,
-0.005866043269634247,
0.07833141833543777,
0.10997878760099411,
-0.06568607687950134,
0.6202030181884766,
-0.6165075302124023,
-0.11687102168798447,
-0.13290560245513916,
0.034561168402433395,
1.317301630973816,
-0.31166872382164,
-0.22626635432243347,
-0.052282653748989105,
0.33441680669784546,
-0.5269857048988342,
0.6476319432258606,
0.5353819131851196,
-0.11604525148868561,
0.47012004256248474,
-0.6258071064949036,
-0.08259618282318115,
-0.45744648575782776,
-0.11073596030473709,
-0.6648479104042053,
0.19867075979709625,
0.003274301765486598,
0.19374363124370575,
0.07336468249559402,
-0.4192039668560028,
-0.18345437943935394,
-0.373430460691452,
-0.2340313047170639,
0.22312389314174652,
0.3893401026725769,
0.486288845539093,
-0.0573544055223465,
0.074867844581604,
0.0681888535618782,
0.35497787594795227,
-0.17735260725021362,
0.4203417897224426,
0.2872338593006134,
0.5256998538970947,
-0.025295283645391464,
0.34929972887039185,
0.18126238882541656,
-0.41036099195480347,
-0.3395969271659851,
-0.20199190080165863,
-0.3392920196056366,
-0.2905321419239044,
-0.258432000875473,
0.027463940903544426,
0.19665271043777466,
-0.38316288590431213,
-0.3489384949207306,
-0.2108670473098755,
-0.30437010526657104,
0.21382242441177368,
-0.44064077734947205,
-0.1156560629606247,
-0.01988225243985653,
0.293366938829422,
-0.19957345724105835,
0.3004077970981598,
0.39647015929222107,
0.6910370588302612,
0.1330679953098297,
0.146571546792984,
-0.10009030997753143,
0.17180775105953217,
0.2531045079231262,
-0.06617246568202972,
0.44186604022979736,
-0.3030179440975189,
0.22244800627231598,
-0.5627301335334778,
0.4090985953807831,
-0.666266918182373,
-0.05443055182695389,
0.40345314145088196,
-0.01707916334271431,
0.029163794592022896,
-0.05608907714486122,
0.42539656162261963,
0.013906527310609818,
-0.4853072762489319,
0.5674831867218018,
0.06940967589616776,
0.6299728751182556,
-0.1500256061553955,
-0.0007664391887374222,
-0.6261652112007141,
-0.49972662329673767,
0.5759713649749756,
0.09873894602060318,
0.014614252373576164,
-0.5183793902397156,
-0.5600047707557678,
0.0394703708589077,
0.3209591805934906,
-0.22537705302238464,
-0.32596465945243835,
0.512833297252655,
-0.49408668279647827,
-0.37981709837913513,
0.42181292176246643,
0.6466962099075317,
-0.004548813682049513,
0.6113764643669128,
0.11386547237634659,
-0.2050597220659256,
-0.6632939577102661,
0.2750554382801056,
0.5991799235343933,
-0.7787339091300964,
-0.3810117840766907,
-0.06186957657337189,
0.3096308708190918,
-0.009782664477825165,
-0.5269660353660583,
0.0007883018697611988,
0.5204863548278809,
-0.1251915991306305,
0.20893101394176483,
-0.05368262156844139,
0.2862875461578369,
0.35471415519714355,
0.021772325038909912,
-0.09167119860649109,
-0.04756339266896248,
0.4418732523918152,
0.5335776209831238,
0.9751572608947754,
0.19700099527835846,
-0.18177545070648193,
-0.4710667133331299,
0.46557116508483887,
0.24743075668811798,
0.07629282027482986,
-0.6214019656181335,
0.4745368957519531,
0.1288483589887619,
0.1490180641412735,
-0.38832592964172363,
0.4325379431247711,
0.014814144000411034,
-0.34087035059928894,
-0.3793615996837616,
-0.4209045171737671,
-0.06335117667913437,
0.5680104494094849,
0.7005547881126404,
0.9698677659034729,
0.06710037589073181,
-0.49388793110847473,
0.5720248222351074,
-0.13506604731082916,
-0.5605595111846924,
0.1354253590106964,
0.17870402336120605,
0.32237446308135986,
0.25031667947769165,
-0.632817804813385,
-0.5412216186523438,
-0.18075299263000488,
-0.21876105666160583,
-0.00865495577454567,
0.25380435585975647,
-0.3053572177886963,
-0.45402926206588745,
-0.35552674531936646,
-0.7858840227127075,
-0.1484857052564621,
-0.2984374165534973,
0.14151686429977417,
-0.3820663392543793,
0.05727382376790047,
0.3165598213672638,
0.19308432936668396,
-0.49498820304870605,
-0.42069342732429504,
0.1436028778553009,
-0.5359044671058655,
0.3992442488670349,
0.3712771236896515,
0.5656368732452393,
-0.3322891592979431,
-0.030202262103557587,
0.5429912805557251,
-0.2836315929889679,
-0.17573560774326324,
-0.8245248198509216,
-0.3810451328754425,
0.17438997328281403,
-0.04457773268222809,
-0.20530834794044495,
-0.29449236392974854,
-0.11120683699846268,
-0.09885521233081818,
-0.14068296551704407,
0.5071257948875427,
0.9151726961135864,
-0.19885599613189697,
0.034618984907865524,
-0.24137179553508759,
-0.057215750217437744,
-0.5190076231956482,
-0.20658670365810394,
0.32964345812797546,
0.5091380476951599,
0.06697510927915573,
0.1709309071302414,
0.2913963198661804,
0.027424367144703865,
0.097547248005867,
0.08545336872339249,
-0.18916399776935577,
-0.3342319130897522,
0.41432833671569824,
-0.5560234189033508,
-0.21329015493392944,
0.6135438084602356,
0.15515229105949402,
-0.5190799832344055,
0.20064018666744232,
-0.11597637087106705,
-0.32043951749801636,
0.6694645285606384,
-0.10332141071557999,
-0.1735178530216217,
-0.44358187913894653,
-0.06427426636219025,
-0.28505703806877136,
0.7762806415557861,
0.620570182800293,
-0.30669429898262024,
0.2191416621208191,
-0.021924184635281563,
0.21899370849132538,
-0.39875197410583496,
0.9329043626785278,
-0.25653547048568726,
0.16999992728233337,
0.07278172671794891,
0.11858666688203812,
-0.9552502036094666,
0.04771081358194351,
0.056228067725896835,
0.6023699045181274,
-0.4630845785140991,
-0.4057689309120178,
-0.5713775157928467,
0.01640269160270691,
-0.3726116418838501,
-0.18896439671516418,
0.24539227783679962,
0.46034011244773865,
0.20003080368041992,
-0.18542394042015076,
-0.5824317932128906,
-0.09015446901321411,
-0.10817065834999084,
-0.09576937556266785,
0.2758077085018158,
0.20361648499965668,
0.12116128206253052,
-0.419560968875885,
0.046269740909338,
-0.08946789801120758,
0.2874377369880676,
0.8565311431884766
] |