Endotoxin regulates corticotropin-releasing hormone receptor 2 in heart and skeletal muscle. 
We tested the effect of endotoxin on the peripheral corticotropin-releasing hormone receptor (CRH-R2), which is highly expressed in the heart.  Systemic injection of LPS markedly downregulated CRH-R2 mRNA levels in the heart in a dose and time dependent manner.  In contrast, CRH-R2 levels in skeletal muscle increased following exposure to endotoxin.  These results suggest that CRH-R2 may be differentially regulated in cardiac tissue and skeletal muscle.  Finding that CRH-R2 expression in the heart is modulated by endotoxin, a potent inducer of cardiovascular dysregulation, suggests a possible link between CRH and the cardiovascular response to stress.