Exploration of deep eutectic solvent-based molecularly imprinted polymers as solid-phase extraction sorbents for screening chloramphenicol in milk. 
Novel deep eutectic solvents modified molecularly imprinted polymers (DESs-MIPs) were synthesized using acrylamide as function monomer, alcohol-based DESs as auxiliary function monomer and chloramphenicol (CAP) as the template.  The DESs modified materials were characterized by Fourier transform infrared and field emission scanning electron microscope.  The adsorption results that the choline chloride/ethylene glycol DESs-based MIPs had stable interactions with CAP.  So the choline chloride/ethylene glycol DESs-based MIPs were applied as sorbent of minimized pipette-tip solid-phase extraction (PT-SPE) for rapid screening CAP from milk sample.  A 1.0 mL washing solvent (n-hexane) and 1.5 mL elution solvent (methanol-acetic acid, 9:1, v/v) were used to purify milk sample by the PT-SPE (recovery of CAP: 96.5%).  Comparing with conventional adsorbents such as C18, choline chloride/ethylene glycol DESs-based MIPs showed higher recognition capability to CAP.  The proposed method combined the advantages of DESs, MIPs and PT-SPE and it could be applied to the rapid screening and enriching CAP from milk sample.