[Study on the pharmacokinetics of cefepime (II)]. 
The pharmacokinetics of 14C-cefepime dihydrochloride (14C-CFPM), was studied in dogs after single intravenous administration at a dose of 20 mg/kg.  Protein binding was also investigated both in vitro and in vivo.  1.  Blood level of radioactivity was 83.53 microns eq./ml at 5 minutes after single intravenous administration and declined biexponentially thereafter.  The values of AUC and T1/2 were 229 microns eq.(.)hr/ml and 90 hours, respectively.  2.  Urinary and fecal excretion rates were 95.1% and 2.7%, respectively.  3.  The in vitro protein binding at 1 to 100 microns/ml of drug concentration was 7.9 to 12.7% in rat, 12.4 to 18.6% in human, and 12.5 to 14.5% in dog.  In vivo protein binding, which increased with time after administration, was 10.8 to 92.9% in rat and 17.5 to 64.9% in dog at 5 minutes to 6 hours.