Evaluation of the efficacy and safety of oral isotretinoin versus topical isotretinoin in the treatment of plane warts: a randomized open trial. 
Plane warts are a common therapeutic problem.  Our aim was to assess the efficacy and safety of oral versus topical isotretinoin in the treatment of plane warts.  Forty patients with multiple plane warts were randomized into two groups.  Group A was treated with oral isotretinoin capsules in the dose of 0.5 mg/kg/d and Group B with topical isotretinoin 0.05% in gel formulation once daily at night.  Treatment was given to the patients for 3 months or until the complete clearance of lesions, whichever was earlier.  Patients with complete response were followed up monthly for 4 months to record the relapse rate.  Results were analyzed in 16 patients of Group A and 13 patients of Group B. At the end of 3 months of therapy, 11 (69%) patients in Group A had complete remission whereas five (31%) had partial remission.  In Group B, at the end of study, five (38%) patients had complete remission and six (46%) had partial remission, whereas two patients had no remission.  The difference was statistically significant between two groups; P < 0.0001.  The most common side effect in Group A was cheilitis.  In Group B, five patients had to be dropped because they developed severe erythema and scaling.  Oral isotretinoin showed better and earlier response than topical isotretinoin.  Oral isotretinoin should definitely be given a trial particularly in cases of multiple facial warts before trying various destructive procedures.