Biomaterials for Skin Substitutes. 
Patients with extensive burns rely on the use of tissue engineered skin due to a lack of sufficient donor tissue, but it is a challenge to identify reliable and economical scaffold materials and donor cell sources for the generation of a functional skin substitute.  The current review attempts to evaluate the performance of the wide range of biomaterials available for generating skin substitutes, including both natural biopolymers and synthetic polymers, in terms of tissue response and potential for use in the operating room.  Natural biopolymers display an improved cell response, while synthetic polymers provide better control over chemical composition and mechanical properties.  It is suggested that not one material meets all the requirements for a skin substitute.  Rather, a composite scaffold fabricated from both natural and synthetic biomaterials may allow for the generation of skin substitutes that meet all clinical requirements including a tailored wound size and type, the degree of burn, the patient age, and the available preparation technique.  This review aims to be a valuable directory for researchers in the field to find the optimal material or combination of materials based on their specific application.