In vitro and in vivo effectiveness of egg yolk antibody against Candida albicans (anti-CA IgY). 
We prepared anti-Candida albicans antibody in chicken egg yolk (anti-CA IgY) and investigated its in vitro and in vivo effectiveness.  Anti-CA IgY significantly reduced the adherence capacity of C. albicans to FaDu cells (human pharynx carcinoma cells) in a dose-dependent manner.  The protective efficacy of anti-CA IgY was investigated in experimentally induced oral candidiasis in immunosuppressed mice.  Oral administration of anti-CA IgY significantly reduced the number of C. albicans and the scores of the tongue lesions.  Moreover, anti-CA IgY reduced the colonization of C. albicans in mice organs.  These results indicate that anti-CA IgY has a protective effect against the oral candidiasis of experimentally infected mice and reduces the dissemination of C. albicans.  Putting together, these results indicate that anti-CA IgY is effective against C. albicans.  This effect might be due to the blocking of the binding of C. albicans to the host cells.  Therefore, anti-CA IgY might be considered as a prophylactic immunotherapy or possibly an adjunctive antifungal therapy.