Childhood bullous pemphigoid treated by i.v.  immunoglobulin. 
Bullous pemphigoid is an acquired autoimmune subepidermal blistering disorder mostly seen in the elderly.  Childhood bullous pemphigoid is very rare.  For the first time we report a case of childhood bullous pemphigoid associated with infantile eczema.  Two weeks after a routine vaccination, a 3.5-month-old boy with infantile eczema developed a generalized blistering disorder.  Histopathology revealed a subepidermal blister.  Direct immunofluorescence showed linear depositions of C3 along the basement membrane zone.  Indirect immunofluorescence studies demonstrated the presence of circulating immunoglobulin G antibodies directed against the epidermal side of salt-split skin.  Enzyme-linked immunosorbent assay demonstrated serum level of anti-BP180 antibody elevated.  The patient was successfully treated by high-dose i.v.  immunoglobulin.