Combined bleomycin and radiotherapy in oral cancer. 
A clinical trial comparing Bleomycin (BLM) plus radiation against radiation alone is reported.  One hundred and fifty-seven previously untreated T3 and T4 and N0, N1 or N2 buccal squamous cell carcinomas were entered.  Eighty-four of these received the combined therapy and 73 were controls.  Cobalt-60 teletherapy using two opposing fields was employed.  BLM was administered intra-arterially in 42 patients, intravenously in 22 patients and intramuscularly in 20 patients.  The 73 controls received physiological saline as a placebo.  Total clinical healing of the lesion within the volume of irradiation eight weeks after the end of radiotherapy was termed a favourable response.  Anything else was a failure.  Five-year recurrence-free rates and disease-free survival were also evaluated.  The favourable response rate in the study group was 78.6% and in the control 19.1%.  The corresponding recurrence-free rates and five-year survival rates were 71.8% and 17%, and 65.5 and 23.5% respectively.  The main toxic features were acute mucositis, pneumonitis and dermatitis.