Speckle tracking analysis allows sensitive detection of stress cardiomyopathy in severe aneurysmal subarachnoid hemorrhage patients. 
Stress cardiomyopathy is a common life-threatening complication after aneurysmal subarachnoid hemorrhage (SAH).  We hypothesized that left ventricular (LV) longitudinal strain alterations assessed with speckle tracking could identify early systolic function impairment.  This was an observational single-center prospective pilot controlled study conducted in a neuro-intensive care unit.  Forty-six patients with severe SAH with a World Federation of Neurological Surgeons grade (WFNS) ≥ III were included.  Transthoracic echocardiography (TTE) was performed on day 1, day 3, and day 7 after the patient's admission.  A cardiologist blinded to the patient's management analyzed the LV global longitudinal strain (GLS).  The control group comprised normal subjects matched according to gender and age.  On day 1 median (25th-75th percentile) GLS was clearly impaired in SAH patients compared to controls [-16.7 (-18.7/-13.7) % versus -20 (-22/-19) %, p < 0.0001], whereas LVEF was preserved [65 (59-70) %].  GLS was severely impaired in patients with a WFNS score of V versus III-IV [-15.6 (-16.9/-12.3) % versus -17.8 (-20.6/-15.8) %, p = 0.008].  Seventeen (37 %) patients had a severe GLS alteration (>- 16 %).  In these patients, GLS improved from day 1 [-12.4 (-14.8/-10.9) %] to last evaluation [-16.2 (-19/-14.6) %, p = 0.0007] in agreement with the natural evolution of stress cardiomyopathy.  On the basis of LV GLS assessment, we demonstrated for the first time that myocardial alteration compatible with a stress cardiomyopathy is detectable in up to 37 % of patients with severe SAH while LVEF is preserved.  GLS could be used for sensitive detection of stress cardiomyopathy.  This is critical because cardiac impairment remains a major cause of morbidity and mortality after SAH.