[Early evening and late evening administration of roxatidine acetate in therapy of duodenal ulcer]. 
In a multicenter, placebo-controlled, comparative trial with 196 general practitioners and internists 730 18 to 70 year-old patients with endoscopic evidence of a duodenal ulcer were enrolled.  Each group of 365 patients received 150 mg Roxatidine acetate once daily, either late in the evening (bedtime administration, between 10.00 p.m. and 11.00 p.m.) or early in the evening (after dinner, between 6.00 p.m. and 7.00 p.m.).  The endoscopic control revealed that the ulcers healed after four weeks of treatment in 74% (bedtime administration) and 77% (administration early in the evening), respectively.  There was no significant difference ascertained between both groups.  At the last visit, epigastric pain was removed during the day in 86% and during the night in 90% in both groups.