Spatiotemporal Hemodynamic Complexity in Carotid Arteries: an Integrated Computational Hemodynamics & Complex Networks-Based Approach. 
The study of the arterial hemodynamics is essential for a better understanding of the risks associated with the onset/progression of vascular disease.  However, conventional quantification and visualization paradigms are not sufficient to fully capture the spatiotemporal evolution of correlated blood flow patterns and their "sphere of influence" in complex vascular geometries.  In the attempt to bridge this knowledge gap, an integrated computational hemodynamics and complex networks-based approach is proposed to unveil organization principles of cardiovascular flows.  The approach is applied to ten patient-specific hemodynamic models of carotid bifurcation, a vascular bed characterized by a complex hemodynamics and clinically-relevant disease.  Correlation-based networks are built starting from time-histories of two fluid mechanics quantities of physiological significance, respectively (1) the blood velocity vector axial component locally aligned with the main flow direction, and (2) the kinetic helicity density.  Unlike conventional hemodynamic analyses, here the spatiotemporal similarity of dynamic intravascular flow structures is encoded in a distance function.  In the case of the carotid bifurcation, this study measures for the first time to what extent flow similarity is disrupted by vascular geometric features.  It emerges that a larger bifurcation expansion, a hallmark of vascular disease, significantly disrupts the network topological connections between axial flow structures, reducing also their anatomical persistence length.  On the contrary, connections in helical flow patterns are overall less geometry-sensitive.  The integrated approach proposed here, by exploiting the connections of hemodynamic patterns undergoing similar dynamical evolution, opens avenues for further comprehension of vascular physiopathology.