NF-kappaB-ISGF3 transcription factor cooperation: coincidence detector or memory chip? 
Induction of gene expression involves deployment of transcription factors.  In this issue of Immunity, Farlik et al. ( 2010) provide a view in which cooperation between transcription factors NF-kappaB and ISGF3 divides the task of transcription by recruiting and activating distinct components of the transcriptional machinery.