[Antibody deficiency syndrome and chromosome aberrations]. 
Chromosome analyses were made on culture lymphozytes from peripheral blood in 37 patients with humoral and local antibody deficiency syndrome.  In one child with humoral IgA-deficiency a ploidymutation of sex chromosomes - a Klinefelter-Syndrome - and a structural variante of chromosome 16 were detected - karyotype 47, XXY, 16q+.  No aberrations of chromosomes 18 and 21 were found out in these phenotypic completely normal children.  Patients with secret-IgA-deficiency in mucosae had normal karyotypes.  Theoretical aspects of possible connection of antibody deficiency syndrome and chromosomal anomalies are discussed.