Synthesis and biological evaluation of a novel series of bis-salicylaldehydes as mushroom tyrosinase inhibitors. 
A series of novel bis-salicylaldehydes were synthesised and evaluated as tyrosinase inhibitors using a tyrosinase-dependent L-DOPA oxidation assay.  The bis-salicylaldehydes exhibited greater inhibitory activity than salicylaldehyde.  Our data suggests that these novel compounds may serve as a structural template for the design and development of novel tyrosinase inhibitors.