Stimuli-enabled zipper-like graphene interface for auto-switchable bioelectronics. 
Graphene interfaces with multi-stimuli responsiveness are of particular interest due to their diverse super-thin interfacial behaviour, which could be well suited to operating complex physiological systems in a single miniaturised domain.  In general, smart graphene interfaces switch bioelectrodes from the hydrophobic to hydrophilic state, or vice versa, upon triggering.  In the present work, a stimuli encoded zipper-like graphene oxide (GrO)/polymer interface was fabricated with in situ poly(N-isopropylacrylamide-co-diethylaminoethylmethylacrylate), i.e., poly(NIPAAm-co-DEAEMA) directed hierarchical self-assembly of GrO and glucose oxidase (GOx).  The designed interface exhibited reversible on/off-switching of bio-electrocatalysis on changing the pH between 5 and 8, via phase transition from super hydrophilic to hydrophobic.  The study further indicated that the zipper-like interfacial bioelectrochemical properties could be tuned over a modest change of temperature (i.e., 20-40°C).  The resulting auto-switchable interface has implications for the design of novel on/off-switchable biodevices with 'in-built' self-control.