Validation of the MedDietScore via the determination of plasma fatty acids. 
The purpose of the present work was to validate the MedDietScore by means of plasma fatty acid levels.  The study sample consisted of 189 men (44+/-13 years old) and 185 women (40+/-15 years old), randomly selected from the ATTICA study database.  All participants completed a food frequency questionnaire (the EPIC-Greek FFQ), and a modified version of the MedDietScore (using weights) was then calculated to evaluate the level of adherence to the Mediterranean diet.  Plasma and dietary fatty acids were measured.  Correlation analysis revealed a strong positive relationship between the MedDietScore, monounsaturated fatty acids (P <0.001), monounsaturated fatty acids to saturated fatty acids (P <0.001), docosahexaenoic acid (22:6 n-3) (P <0.05) and n-3 fatty acids (P <0.001), and inverse correlations between the diet score and polyunsaturated fatty acids (comprised of the sum of n-3 and n-6 fatty acids) (P <0.001), saturated fatty acids (P <0.01), and total n-6 fatty acids (P <0.001).  The effect size of the relationships between the weighted-MedDietScore and fatty acids was better than the relationships with the initial version of the diet score.  Our findings suggest that the modified MedDietScore is a valid measure of various plasma fatty acids, and may prove a useful tool in assessing diet quality of adults.