Burn wound sepsis: effect of delayed treatment with topical chemotherapy on survival. 
Using a standardized laboratory rat model of burn wound sepsis, a regimen of once a day application of Silvadene has been found to be more effective treatment than Sulfamylon or cerium-Silvadene.  Delaying treatment following infection resulted in decreased survival.  Possible reasons for difference in mortality are once-daily application, or perhaps a change in sensitivity between drugs and the infective organism (Ps.  aeruginosa) over time.