Transplantation of autologous perichondrium with amniotic membrane for progressive scleral necrosis. 
Scleral necrosis with severe ischemia is refractory to conventional treatment because of avascular progressive necrosis.  We assessed the therapeutic efficacy and safety of autologous perichondrium transplantation in patients with progressive scleral necrosis (PSN) and analyzed the clinical effects.  This study was a prospective, interventional, and noncomparative case series.  Reconstructive surgery using autologous perichondrium and amniotic membrane (AM) was performed in patients with PSN who showed progressive ischemic scleral melting with impending perforation state and/or broad avascular area larger than 10 mm in diameter.  The primary outcome was restoration of scleral integrity with healthy vascularized epithelium over the graft at six months after surgery.  The secondary outcome was complication rate associated with autologous perichondrium graft use.  Eighteen eyes of 14 patients underwent reconstructive surgery using autologous perichondrium patch and AM grafts.  Observations indicated the graft provided the eyeball with successful structural integrity in 17 out of the 18 cases (94.4%) at six months after surgery.  One eye showed a small scleral defect due to wound dehiscence at four month after the surgery.  Additional surgery using perichondrium and AM stabilized the eye.  The scleral necrosis healed completely after perichondrium and AM transplantation, even in cases with full-thickness scleral defect.  The scleral integrity was maintained until the last follow-up session.  There were no serious complications of endophthalmitis or graft infection.  Reconstructive surgery using autologous perichondrium and AM is an effective method for restoration of scleral integrity and vascularization of the episclera and conjunctiva in eyes with PSN.  Therefore, autologous perichondrium can be considered as an appropriate new biologic tissue for PSN.