Combining Visible-Light-Photoredox and Lewis Acid Catalysis for the Synthesis of Indolizino[1,2-b]quinolin-9(11H)-ones and Irinotecan Precursor. 
One-step construction of substituted indolizino[1,2-b]quinolin-9(11H)-ones was achieved by combining visible-light-photoredox and Lewis acid catalysis for an intramolecular Povarov cycloaddition reaction under mild conditions.  In this catalytic process, the visible-light-promoted dehydrogenation protocol of tetrahydroquinolines constitutes the key procedure.  Moreover, this method can be applied to the formal synthesis of the precursor of irinotecan, which exhibited good anticancer activities.