An 18-month follow-up study on the influence of smoking on blood antioxidant status of teenage girls in comparison with adult male smokers in Korea. 
The influence of cigarette smoking on blood antioxidant status in teenage girls with a history of short-term smoking was followed over 18 mo.  Data obtained from female senior high school students (ages 14 to 18 y) in Korea were compared with data obtained from adult male smokers (ages 36 to 51 y) with a long history of smoking and living in the same geographic areas as the teenage subjects.  A smoker was a person who had smoked at least three cigarettes a day for at least 1 y for teenagers (n = 35) or at least 10 cigarettes a day for at least 13 y for adults (n = 20).  Serum, urine, and anthropometric data were obtained from teenagers every 6 mo over an 18-mo period.  Samples were collected once from adults.  Data were analyzed by Student's t test and Fisher's protected least significant difference test for comparing smokers and non-smokers and for analyzing period effects in each group.  Serum nicotine and cotinine concentrations were higher in smokers than in non-smokers.  Blood pressures were higher in teenage (at 0 and 12 mo) and adult smokers than in non-smokers.  Extracellular superoxide dismutase activities and concentrations of serum vitamin C and folate were lower in smokers in the teenage (at 0, 12, or 18 mo) and adult groups.  Serum ceruloplasmin activities and thiobarbituric acid-reactive substance production were not influenced by smoking.  In adults, serum copper concentrations were higher in smokers than in non-smokers.  This parameter for teenagers did not change consistently throughout the study.  Similar to adults, cigarette smoking by teenagers has a negative effect on oxidant defense systems.