[Progress in mesenchymal stem cells aging]. 
To comprehensively analyze the recent advancements in the field of mesenchymal stem cells (MSCs) aging, and summary its achievements and its difficulty at the present.  The literature about MSCs aging was reviewed and analyzed.  Inducible telomerase reactivation of MSCs is successful to extend the life span of senescent cells, but it also has potential safety hazard.  The age range presented in the research of age-related cell senescence is inconsistent, resulting in different outcomes.  Many ways to improve cell in vitro culture conditions will help delay aging.  Recent research indicates that oxidative stress theory is seemed to not completely explain cell aging.  Further research of MSCs aging mechanism will help the tissue engineering transform to clinical application.