Debridement of experimental full-thickness skin burns of rats with enzyme fractions derived from pineapple stem. 
A limited in vivo study using 12 rats with full-thickness skin burns injuries was carried out.  The animals were treated 24 h postburn with two newly discovered enzyme fractions derived from the stem of the pineapple (Ananas comosus).  The results indicated that even debridement of the injury could be effected rapidly (within 4 h).  Although the details of enzyme formulation and clinical application have yet to be established, these findings clearly suggest that two enzyme fractions from pineapple stem have potential as non-surgical debriding agents.