Q:

How to center a wx. BusyInfo() - wxpython? 

Looking at the API there doesn't seem to be a way to center a wx. BusyInfo message to the center of the screen like with other pop  up modals by using Center(). 
Is there a way to center wx. BusyInfo()?  

A:

not with wx. BusyInfo, as far as I know (although it should be already centered by default... have you tried not giving a parent window to the wx. BusyInfo?).  
Alternatively, you may want to try wx.lib.agw. PyBusyInfo instead: if it doesn't do exactly what you need, you can always hack it to suit your needs (it's pure Python). 
Hope this helps. 
Andrea.