Effect of specific thromboxane-synthetase inhibition on thromboxane and prostaglandin synthesis in stable angina induced by exercise test. 
14 patients with effort induced angina pectoris were treated with a specific TxB2 inhibitor Dazoxiben or verapamil for two weeks with a wash-out period of 14 days between the two regimens.  A sub-maximal bicycle test was performed before treatment and at the end of each treatment period.  The bicycle test induced a significant increase in serum TxB2 in patients without treatment and during verapamil therapy.  This increase was significantly inhibited by Dazoxiben treatment.  No alterations in plasma TxB2 or 6-keto-PGF1 alpha were observed on either regimen.  Dazoxiben had no clinical effect, while verapamil caused a highly significant prolongation of exercise time.