Alternative names for C9orf25 antibody

SwissProt ID

Gene ID

Ncbi ID

Available reactivities

Bov (Bovine), Hu (Human), Ms (Mouse), Rt (Rat), Ze (Zebrafish)

Available hosts

Rabbit, Mouse

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P)

Background of C9orf25 antibody

C9orf25 (chromosome 9 open reading frame 25) is a 185 amino acid protein that exists as seven alternatively spliced isoforms that are encoded by a gene located on human chromosome 9.  Chromosome 9 consists of about 145 million bases, represents 4% of the human genome and encodes nearly 900 genes.  Thought to play a role in gender determination, deletion of the distal portion of 9p can lead to development of male to female sex reversal, the phenotype of a female with a male X,Y genotype.  Hereditary hemorrhagic telangiectasia, which is characterized by harmful vascular defects, is associated with the chromosome 9 gene encoding endoglin protein, ENG.  Familial dysautonomia is also associated with chromosome 9 though through the gene IKBKAP.  Notably, chromosome 9 encompasses the largest interferon family gene cluster.  Chromosome 9 is partnered with chromosome 22 in the translocation leading to the aberrant production of BCR-ABL fusion protein often found in leukemias.