Effect of some benzamide derivatives on stress-induced behavior and striatum dopamine receptors. 
The effects of a new benzamide derivative LIS-630 and the well-known neuroleptic, tiapride, were studied on stress-induced hyper- and hypoactive emotional behavioral reaction of animals depending on the individual ability for perceptive-cognitive activity in stress situations, and their affinity to striatal DA receptors.  A modified variant of forced swimming method was used.  The affinity of the substances to striatal DA receptors was studied by the radioligand binding method using 3H-spiroperidol.  The results show that the psychopharmacological profile of LIS-630 differs significantly from the neuroleptic, tiapride.  LIS-630 restored escape behavior from stress situation after preliminary exposure of rats to forced swimming and did not disturb escape behavior in animals more resistant to emotional hypoactivity.  LIS-630 reduced immobility time at forced swimming.  However, it is not effective in preventing hyperemotional reactions induced by L-dopa and stress.  The radioligand binding study shows that LIS-630 did not displace 3H-spiroperidol from the binding sites of striatum membranes.  The parameters of displacement with tiapride were satisfactory.