Multiple organ failure: is it disappearing? 
The incidence of multiple organ failure (MOF) during the last decade has been reported variously as 2% to 25%, depending on the patient population examined.  The mortality rate from this devastating complication ranges from 40% to 80%.  Although the incidence has not changed during the last decade, it does not mean that there has been no progress.  Tertiary centers are now seeing trauma and nontrauma patients who have more significant underlying disease and injuries.  Likewise, a higher percentage of our trauma patients are now referred from outside institutions where there may not be the facilities to administer the complex, rapid resuscitation these patients require.  Prevention of MOF remains its best treatment.  Rapid, adequate volume resuscitation, adequate nutrition, appropriate antibiotic usage, and aggressive pulmonary management are important for preventing the downward physiologic spiral that leads to MOF and death.  Once MOF has occurred, it is not clear that these same measures are as effective in altering outcome.