Dysregulated Iron Metabolism-Associated Dietary Pattern Predicts an Altered Body Composition and Metabolic Syndrome. 
Diet plays an important role in the development of obesity and may contribute to dysregulated iron metabolism (DIM).  A cross-sectional survey of 208 adults was conducted in Taipei Medical University Hospital (Taipei, Taiwan).  A reduced-rank regression from 31 food groups was used for a dietary pattern analysis.  DIM was defined as at least four of the following criteria: serum hepcidin (men >200 ng/mL and women >140 ng/mL), hyperferritinemia (serum ferritin of >300 ng/mL in men and >200 ng/mL in women), central obesity, non-alcoholic fatty liver disease, and two or more abnormal metabolic profiles.  Compared to non-DIM patients, DIM patients were associated with an altered body composition and had a 4.52-fold (95% confidence interval (CI): (1.95-10.49); p < 0.001) greater risk of metabolic syndrome (MetS) after adjusting for covariates.  A DIM-associated dietary pattern (high intake of deep-fried food, processed meats, chicken, pork, eating out, coffee, and animal fat/skin but low intake of steamed/boiled/raw foods and dairy products) independently predicted central obesity (odds ratio (OR): 1.57; 95% CI: 1.05-2.34; p < 0.05) and MetS (OR: 1.89; 95% CI: 1.07-3.35; p < 0.05).  Individuals with the highest DIM pattern scores (tertile 3) had a higher visceral fat mass (%) (β = 0.232; 95% CI: 0.011-0.453; p < 0.05) but lower skeletal muscle mass (%) (β = -1.208; 95% CI: -2.177--0.239; p < 0.05) compared to those with the lowest DIM pattern scores (tertile 1).  In conclusion, a high score for the identified DIM-associated dietary pattern was associated with an unhealthier body composition and a higher risk of MetS.